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Uij^.@M]i/7vTa^ޭ*X.uT\(UЂ@ V`A*y`( ⣕Z6m-ӎhLfS~wXuvܙswrL;eoxwēES u=87n^CZ:Yv 9(J`!\l{@^0 *$9q>,"<7a:D@8:cKJ"d}f6",=x7䮮p^і֌!JE A-Ʊi%TSi=_xV;Fq.:9 ry%Dn8FNVWSX_\n3J/,q#A&0qS<:NX+/|:kheK: mn{͓ h90S x%f1pVPXŝ0yW`ꤌxZ.(`3WS;5uo|w@A'gNȦbHPZP |[nQ;~o*rvy a8-D ]3+g~58pt.\ 2%%;6 DU\dbf|WO'Lp4Ih%;YMZ"a1O"ؔA5)DN00MUbvdsXau0}7* M6mM3l2+[Fmb9aq- ylYOkPj?MN8wAh]X+Z!/р1ny/`õmbXx^{=w!ۂ\ Z xr' W_a7h6J~]7%}mܲeyV% uě׎7^diG)ގlb:}Oa3<DZ';s#|;eOv5s_Tk{T ktB零"=*|cXʅi Q$Y #-hQn"3? tCƒx| X<$hQn0%ڧ j]kVZ\=7&n%S5E} p)[U8J:dU5>?Y*JuDrS’T6"bݾҚJx|{nm*kjbzM:]{9TXX),;qi%VVK 8ihuuR*U(B3p?oY~kD{G~K+[YY]ܙY=2h8\]Q4"yp,gbu(OL:9/Ŝ < ^ț7IX"ccB>i#lG~|.6*Zٖ`&:/3HGK.UmxPvҏH9ɿq30c'm{qwRfNWnv,57s4!R`AaDŽ( n6/>mF}HrFTj+BMcɕ(ȞVئc;9:7𷷇)m_ZZ39zVM, Q*E(' U*r'VP.+wj]/}~ς{͜}+V憮6NOlN|>RQJnWw5 ֭[lݺer}Gƽ[~"`V39O?>3 Ĭ~;@ð5Y3<`f|1䤙ӿ3wUJ<<ϹsX&c(@YW endstream endobj 102 0 obj <> endobj 103 0 obj <> endobj 120 0 obj [131 0 R 132 0 R 133 0 R 134 0 R 135 0 R 136 0 R 137 0 R 138 0 R 139 0 R] endobj 121 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\240\021\001\202\215\025\b)-9.9(\026\021\017\001 \211\021\r\016\201\026\021\017\200\t\004\201\215\220 \026\ )11.1(\025\t\b)-10(\026)11(\025\017\021\020\016\f\215\220 )]TJ 0 -1 TD [(\017\201\025\r\025\026)11(\016\f\016\215\021\207 \(\025\235\213\025\201 \t\021\026)11(\016\201\001\026)-19.9(\200\201\220\))]TJ 39.93 1 Td [(Diagnostics of\022div)12.1(er)-20(ticular colonic bleeding \(r)31(e)11(vie)11(w\))]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0.018 Tc 0.669 Tw 8 0 0 8 42.5197 731.2159 Tm (of)Tj /Span<>> BDC ( )Tj EMC [(Col)29.6(onic Di)-16.4(ver)-22.4(t)-32.4(icul)-16.4(ar Hemor)-24.5(r)-24.4(ha)-17.4(ge)]TJ /T1_2 1 Tf (. 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Successful end)-16(oscopic hemo)]TJ 0 Tw (-)Tj -1.796 -1.25 Td [(st)15(asis com)10(p)32(ar)-24(ed t)17(o)]TJ /Span<>> BDC ( )Tj EMC [(tr)-32.9(ansar)-22(ter)-37(ial embol)-31(iza)15.1(t)-32(ion in p)32(a)15(t)-32(ients wi)-24(t)-13(h col)30(on)]TJ (-)Tj 0.125 Tw T* [(ic di)-15.9(ver)-22(t)-32(icul)-16(ar bleeding. )]TJ /T1_2 1 Tf [(J Clin Biochem N)21(utr)]TJ /T1_1 1 Tf (. 2022;70\(3\):283\226289. )Tj 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.3164/jcbn.21-123)Tj 0 0 0 1 k /GS1 gs 0.272 Tw -1.847 -1.25 Td (49.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Hir)-33(ai)]TJ /Span<>> BDC ( )Tj EMC [(Y, U)15(r)-33(aok)-17(a)]TJ /Span<>> BDC ( )Tj EMC [(T, W)12(ad)42(a)]TJ /Span<>> BDC ( )Tj EMC [(M, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. 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Ul)56(tr)-33(aselec)-15.9(t)-32(i)-16(ve tr)-32.9(ansca)15(t)-13(h)]TJ 0 Tw (-)Tj 0.326 Tw 27.259 16.25 Td [(e)-12(ter ar)-22(ter)-36.9(ial embol)-30.9(iza)15(t)-32(ion wi)-24(t)-13(h s)26(mall-sized micr)-32(o)-16(coils for a)-17(cute )]TJ 0.011 Tc 0.421 Tw T* [(l)29.7(o)-14.4(wer gastr)-32.4(ointest)-32.3(inal bleeding. )]TJ /T1_2 1 Tf [(CVIR Endov)15.7(asc)]TJ /T1_1 1 Tf [(. 2021;4\(1\):28.)11( )]TJ 0 Tc 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1186/s42155-021-00215-9)Tj 0 0 0 1 k /GS1 gs 0.13 Tw -1.847 -1.25 Td (52.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(K)25(ojima)]TJ /Span<>> BDC ( )Tj EMC [(Y, K)-16(a)15(t)15.1(ano)]TJ /Span<>> BDC ( )Tj EMC [(T, S)-16(himur)-32.9(a)]TJ /Span<>> BDC ( )Tj EMC [(T, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Ef)-56(f)-28(ica)-17(cy of)]TJ /Span<>> BDC ( )Tj EMC [(tr)-32.9(ansca)15(t)-13(he)-12(ter )]TJ 0.08 Tw -1.796 -1.25 Td [(ar)-22(ter)-36.9(ial embol)-31(iza)15(t)-32(ion for f)-27.9(ir)-10(st-l)-31(ine tr)-23.9(ea)15(tment of)]TJ /Span<>> BDC ( )Tj EMC [(col)30(onic di)-16(ver)-22(t)-31.9(icul)-16(ar )]TJ -0.022 Tw T* [(bleeding wi)-23.9(t)-13(h e)-18(xtr)-32.9(av)-15(asa)15(t)-32(ion on contr)-32.9(ast-enhanced com)10(puted t)17.1(omo)-16(g)]TJ 0 Tw (-)Tj T* [(r)-33(aphy. )]TJ /T1_2 1 Tf 0.21 Tw 3.016 0 Td (Medicine \(Baltimore\))Tj /T1_1 1 Tf [(. 2022;101\(44\):e31442. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1097/)Tj -3.016 -1.25 Td (MD.0000000000031442)Tj 0 0 0 1 k /GS1 gs 0.179 Tw T* (53.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Ki)-24(t)15(amur)-32.9(a)]TJ /Span<>> BDC ( )Tj EMC [(R, Mar)-22(uhashi)]TJ /Span<>> BDC ( )Tj EMC [(T, W)20(o)-16(odhams)]TJ /Span<>> BDC ( )Tj EMC [(R, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Car)-24(bon dio)14(xide-)]TJ 0.011 Tw -1.796 -1.25 Td [(enhanced angio)-16(gr)-33(aphy for de)-12(tec)-16(t)-31.9(ion of)]TJ /Span<>> BDC ( )Tj EMC [(col)30(onic di)-16(ver)-21.9(t)-32(icul)-16(ar bleeding )]TJ 0.11 Tw T* [(and cl)-30.9(inical outcomes. )]TJ /T1_2 1 Tf [(CVIR Endov)16(asc)]TJ /T1_1 1 Tf [(. 2024;7\(1\):67. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1186/)Tj T* (s42155-024-00481-3)Tj 0 0 0 1 k /GS1 gs -0.023 Tw T* (54.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(W)-16(ilk)-15.9(ins)]TJ /Span<>> BDC ( )Tj EMC [(T, Bair)-24(d)]TJ /Span<>> BDC ( )Tj EMC [(C, P)30(ear)-10(son)]TJ /Span<>> BDC ( )Tj EMC [(A, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. 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Ear)-29.9(l)35(y V)30(er)-9.9(sus Del)-15.9(a)15(yed )]TJ 0.224 Tw -1.796 -1.25 Td [(Col)30(onoscopy in Hospi)-24(t)15(al)-31(ized P)40(a)15(t)-31.9(ients W)-16(i)-24(t)-13(h L)35(o)-13.9(wer Gastr)-32(ointest)-31.9(inal )]TJ -0.026 Tw T* (Bleeding: A)Tj /Span<>> BDC ( )Tj EMC [(Me)-12(t)15(a-Anal)35(y)-13(sis. )]TJ /T1_1 1 Tf (J Clin Gastroenterol)Tj /T1_0 1 Tf (. 2017;51\(4\):352\226359. )Tj 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1097/MCG.0000000000000602)Tj 0 0 0 1 k /GS1 gs 0.137 Tw -1.847 -1.25 Td (21.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Jensen)Tj /Span<>> BDC ( )Tj EMC [(DM. Dia)-17(gnosis and tr)-24(ea)15(tment of)]TJ /Span<>> BDC ( )Tj EMC [(def)-28(ini)-23.9(t)-32(i)-16(ve di)-16(ver)-21.9(t)-32(icul)-16(ar )]TJ 0.183 Tw -1.796 -1.25 Td [(hemor)-24(r)-23.9(ha)-17(ge \(DDH\). )]TJ /T1_1 1 Tf (Am J Gastroenterol)Tj /T1_0 1 Tf (. 2018;113\(11\):1570\2261573. )Tj 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1038/s41395-018-0061-4)Tj 0 0 0 1 k /GS1 gs 0.005 Tc 0.349 Tw -1.847 -1.25 Td [(2)0.5(2)0.6(.)]TJ /Span<>> BDC 1.309 0 Td ( )Tj EMC 0.504 0 Td [(O)-15.5(c)0.6(h)0.5(i)]TJ /Span<>> BDC 1.825 0 Td ( )Tj EMC [(M)0.5(,)0.6( K)-15.4(a)0.6(m)0.5(o)0.5(s)0.6(h)0.5(i)0.6(d)42.5(a)]TJ /Span<>> BDC 6.401 0 Td ( )Tj EMC [(T)0.5(,)0.6( H)0.6(a)0.5(m)0.6(a)0.5(n)0.6(o)]TJ /Span<>> BDC 5.133 0 Td ( )Tj EMC [(Y)0.5(,)0.6( e)-11.5(t)]TJ /Span<>> BDC 2.689 0 Td ( )Tj EMC [(a)0.5(l)0.6(.)0.5( E)0.6(a)0.5(r)-29.4(l)35.5(y)0.6( c)0.6(o)0.5(l)30.6(o)0.5(n)0.6(o)0.5(s)0.5(c)0.6(o)0.5(p)0.6(y)5( )]TJ 0 Tc 0.244 Tw -17.861 -1.25 Td [(and )0.6(ur)-32(gent )0.6(contr)-33(ast )0.6(enhanced )0.6(com)10(puted )0.6(t)17(omo)-16(gr)-33(aphy )0.6(for )0.6(col)30(onic )]TJ 0.097 Tw T* [(di)-16(ver)-21.9(t)-32(icul)-16(ar bleeding r)-23.9(educes r)-36.9(isk of)]TJ /Span<>> BDC ( )Tj EMC [(r)-24(ebleeding. )]TJ /T1_1 1 Tf [(W)29(orld J Clin Cases)]TJ /T1_0 1 Tf 0 Tw (. )Tj 0.023 Tw T* [(2021;9\(11\):2446\2262457. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.12998/wjcc.v9.i11.2446)Tj 0 0 0 1 k /GS1 gs 0.117 Tw T* (23.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Ni)-16(ikur)-32.9(a)]TJ /Span<>> BDC ( )Tj EMC [(R, Na)-16.9(ga)15(t)15(a)]TJ /Span<>> BDC ( )Tj EMC [(N, Aok)-16(i)]TJ /Span<>> BDC ( )Tj EMC [(T, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. P)35(r)-24(edic)-16(t)17(or)-9.9(s for ident)-32(if)-28(ica)15(t)-32(ion )]TJ 0.187 Tw -1.796 -1.25 Td (of)Tj /Span<>> BDC ( )Tj EMC [(st)-32(igma)15(t)15(a of)]TJ /Span<>> BDC ( )Tj EMC [(r)-24(ecent hemor)-24(r)-23.9(ha)-17(ge on col)30.1(onic di)-16(ver)-21.9(t)-32(icul)-16(a in l)30(o)-13.9(wer )]TJ 0.124 Tw T* [(gastr)-32(ointest)-31.9(inal bleeding. )]TJ /T1_1 1 Tf (J Clin Gastroenterol)Tj /T1_0 1 Tf (. 2015;49\(3\):e24\22630. )Tj 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1097/MCG.0000000000000140)Tj 0 0 0 1 k /GS1 gs 0.268 Tw -1.847 -1.25 Td (24.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Se)-12(t)-13(h)]TJ /Span<>> BDC ( )Tj EMC (A, Khan)Tj /Span<>> BDC ( )Tj EMC [(MA, N)-14(oll)-16(an)]TJ /Span<>> BDC ( )Tj EMC [(R, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Does U)15(r)-32(gent Col)30(onoscopy )]TJ 0.257 Tw -1.796 -1.25 Td [(Im)10(p)25(r)-32(ove )0.6(Outcomes )0.6(in )0.6(t)-13(he)]TJ /Span<>> BDC ( )Tj EMC 11.367 0 Td [(Mana)-17(gement )0.6(of)]TJ /Span<>> BDC ( )Tj EMC 6.949 0 Td [(L)35(o)-14(wer )0.6(Gastr)-32(ointest)-31.9(inal )]TJ 0 Tw -18.316 -1.25 Td (Bleeding? )Tj /T1_1 1 Tf 0.322 Tw 4.518 0 Td (Am J Med Sci.)Tj /T1_0 1 Tf [( 2017;353\(3\):298\226306. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1016/j.)Tj -4.518 -1.25 Td (amjms.2016.11.007)Tj 0 0 0 1 k /GS1 gs 0.029 Tw T* (25.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(K)25(ouand)42(a)]TJ /Span<>> BDC ( )Tj EMC [(AM, S)-16(omsouk)]TJ /Span<>> BDC ( )Tj EMC (M, Sewell)Tj /Span<>> BDC ( )Tj EMC [(JL, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. U)15(r)-32(gent col)30(onoscopy in )]TJ 0.027 Tw -1.796 -1.25 Td [(p)32(a)15(t)-32(ients wi)-24(t)-13(h l)30(o)-14(wer GI bleeding: a)]TJ /Span<>> BDC ( )Tj EMC [(sy)-12.9(stema)15(t)-32(ic r)-24(ev)-16(iew and me)-12(t)15(a-anal)]TJ 0 Tw (-)Tj T* [(y)-13(sis. )]TJ /T1_1 1 Tf 0.213 Tw 2.257 0 Td (Gastrointest Endosc)Tj /T1_0 1 Tf [(. 2017;86\(1\):107\226117.e1. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1016/j.)Tj -2.257 -1.25 Td (gie.2017.01.035)Tj 0 0 0 1 k /GS1 gs 0.013 Tw T* (26.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Ni)-16(ikur)-32.9(a)]TJ /Span<>> BDC ( )Tj EMC [(R, Na)-17(ga)15(t)15(a)]TJ /Span<>> BDC ( )Tj EMC [(N, Y)50(amad)42(a)]TJ /Span<>> BDC ( )Tj EMC [(A, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Ef)-55.9(f)-28(ica)-17(cy and Safe)-11.9(t)-10(y of)]TJ /Span<>> BDC ( )Tj EMC [(Ear)-30(l)35(y )]TJ 0.112 Tw -1.796 -1.25 Td [(vs Elec)-15.9(t)-32(i)-16(ve Col)30(onoscopy for A)-25(cute L)35.1(o)-14.1(wer Gastr)-31.9(ointest)-32(inal Bleeding. )]TJ /T1_1 1 Tf 0.011 Tc -0.011 Tw T* (Gastroenterology. )Tj /T1_0 1 Tf 0.418 Tw 7.792 0 Td [(2020;158\(1\):168\226175.e6. d)-16.3(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs -0.011 Tw (10.1053/j.gas)Tj 0 Tc 0 Tw (-)Tj -7.792 -1.25 Td [(tr)-32(o.2019.09.010)]TJ 0 0 0 1 k /GS1 gs 0.332 Tw T* (27.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Ni)-16(ikur)-32.9(a)]TJ /Span<>> BDC ( )Tj EMC 3.503 0 Td [(R, )0.5(Na)-17(ga)15(t)15(a)]TJ /Span<>> BDC ( )Tj EMC 4.658 0 Td [(N, )0.5(S)-16(himbo)]TJ /Span<>> BDC ( )Tj EMC 4.901 0 Td [(T, )0.5(e)-12(t)]TJ /Span<>> BDC ( )Tj EMC 2.606 0 Td [(al. )0.5(A)15(d)-17(ver)-9.9(se )0.5(Events )0.5(dur)]TJ 0 Tw 9.821 0 Td (-)Tj 0.328 Tw -27.286 -1.25 Td [(ing )0.5(Bo)-14(wel )0.5(P)35(r)-24(ep)32.1(ar)-33(a)15(t)-32(ion )0.5(and )0.5(Col)30(onoscopy )0.5(in )0.5(P)40(a)15(t)-32(ients )0.5(wi)-23.9(t)-13(h )0.5(A)-25(cute )]TJ 0.01 Tc 0.386 Tw T* [(L)34.7(o)-14.4(wer )0.6(Gastr)-32.3(ointest)-32.3(inal )0.6(Bleeding )0.5(Com)9.7(p)31.6(ar)-24.3(ed )0.6(wi)-24.3(t)-13.3(h )0.6(Elec)-16.3(t)-32.4(i)-16.3(ve )0.6(N)-14.3(on-)]TJ 0.018 Tc 0.649 Tw T* [(Gastr)-31.8(ointest)-31.9(inal Bleeding. )]TJ /T1_1 1 Tf (PLoS One)Tj /T1_0 1 Tf [(. 2015;10\(9\):e0138000.)18( )]TJ 0 Tc 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td [(10.1371/jour)-14.9(nal.pone.0138000)]TJ 0 0 0 1 k /GS1 gs 0.137 Tw -1.847 -1.25 Td (28.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(G)20(r)-33(alnek)]TJ /Span<>> BDC ( )Tj EMC 3.389 0 Td [(IM, )0.5(Neeman)]TJ /Span<>> BDC ( )Tj EMC 5.191 0 Td [(Z, )0.5(S)15(tr)-33(a)15(te)]TJ /Span<>> BDC ( )Tj EMC 3.783 0 Td [(LL. )0.5(A)-25(cute )0.5(L)35(o)-14(wer )0.5(Gastr)-31.9(ointest)-32(inal )]TJ 0 Tw -14.159 -1.25 Td (Bleeding. )Tj /T1_1 1 Tf 0.224 Tw 4.29 0 Td [(N Eng)13(l J Med)]TJ /T1_0 1 Tf [(. 2017;376\(11\):1054\2261063. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1056/)Tj -4.29 -1.25 Td (NEJMcp1603455)Tj 0 0 0 1 k /GS1 gs 0.092 Tw T* (29.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(P)10(ont)17(one)]TJ /Span<>> BDC ( )Tj EMC [(S, P)40(alma)]TJ /Span<>> BDC ( )Tj EMC [(R, P)40(ane)-12(t)-30(t)15(a)]TJ /Span<>> BDC ( )Tj EMC [(C, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. P)10(ol)35(ye)-12(t)-12.9(hylene gl)35(ycol-based )]TJ -0.014 Tw -1.796 -1.25 Td [(bo)-14(wel p)25(r)-23.9(ep)32(ar)-33(a)15(t)-32(ion befor)-23.9(e col)30(onoscopy for selec)-15.9(ted in)11(p)32(a)15(t)-32(ients: A)]TJ /Span<>> BDC ( )Tj EMC [(pil)30(o)17(t )]TJ 0 Tw T* [(stud)17(y. )]TJ /T1_1 1 Tf 0.023 Tw 2.739 0 Td (J Dig Dis)Tj /T1_0 1 Tf [(. 2018;19\(1\):40\22647. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1111/1751-2980.12571)Tj 0 0 0 1 k /GS1 gs 0.29 Tw -2.739 -1.25 Td (30.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Mal)-31(ik)]TJ /Span<>> BDC ( )Tj EMC [(A, Ina)15(y)22(a)15(t)]TJ /Span<>> BDC ( )Tj EMC [(F, Gor)-33(a)15(y)22(a)]TJ /Span<>> BDC ( )Tj EMC [(MHN, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Sever)-23.9(e A)-25(cute Col)30(onic )]TJ 0.001 Tc 0.35 Tw -1.796 -1.25 Td [(Di)-16.2(ver)-22.2(t)-32.2(icul)-16.3(ar Bleeding: T)46.8(he)]TJ /Span<>> BDC ( )Tj EMC [(Ef)-56.2(f)-28.3(ica)-17.3(cy of)]TJ /Span<>> BDC ( )Tj EMC [(R)-10.3(apid Bo)-14.3(wel P)34.7(r)-24.2(ep)31.7(ar)-33.3(a)14.8(t)-32.3(ion)1( )]TJ 0.011 Tc 0.421 Tw T* [(W)-16.3(i)-24.4(t)-13.3(h 1 L P)9.7(ol)34.7(ye)-12.3(t)-13.3(hylene Gl)34.7(ycol Ascor)-24.4(ba)14.6(te S)-16.3(ol)34.7(ut)-32.3(ion and Dir)-24.3(ec)-16.4(t)11( )]TJ 0.004 Tc 0.35 Tw T* [(End)-16.2(oscopic Hemo)-16.2(cl)-31.3(ipping for Successful Hemost)14.8(asis. )]TJ /T1_1 1 Tf [(J In)10.8(v)12.7(estig)4( )]TJ 0.024 Tc 0.867 Tw T* [(Med High Im)16(pact Case R)20.9(ep)]TJ /T1_0 1 Tf [(. 2021;9:2324709621994383.)24( )]TJ 0 Tc 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1177/2324709621994383)Tj 0 0 0 1 k /GS1 gs -0.004 Tw -1.847 -1.25 Td (31.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Maid)42(a)]TJ /Span<>> BDC ( )Tj EMC [(M, Ma)-17(cal)35(uso)]TJ /Span<>> BDC ( )Tj EMC [(FS, Sfer)-24(r)-33(a)-23.9(z)-24(za)]TJ /Span<>> BDC ( )Tj EMC [(S, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Ef)-56(fec)-16(t)-32(i)-15.9(veness and safe)-12(t)-10(y )]TJ 0.251 Tw -1.796 -1.25 Td (of)Tj /Span<>> BDC ( )Tj EMC [(NER1006 ver)-9.9(sus st)15.1(and)41.9(ar)-23.9(d bo)-14(wel p)25(r)-24(ep)32.1(ar)-33(a)15(t)-32(ions: A)]TJ /Span<>> BDC ( )Tj EMC 22.102 0 Td [(me)-12(t)15(a-anal)35.1(y)-13(sis )]TJ 0.025 Tw 6.953 81.25 Td (of)Tj /Span<>> BDC ( )Tj EMC [(r)-33(and)-15.9(omized phase-3 cl)-31(inical tr)-37(ials. )]TJ /T1_1 1 Tf [(Dig Liv)13(er Dis)]TJ /T1_0 1 Tf (. 2020;52\(8\):833\226)Tj 0.023 Tw T* [(839. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1016/j.dld.2020.05.046)Tj 0 0 0 1 k /GS1 gs -0.021 Tw T* (32.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(K)25(oba)15(y)22(ashi)]TJ /Span<>> BDC ( )Tj EMC [(M, Ak)-16(iy)22(ama)]TJ /Span<>> BDC ( )Tj EMC [(S, Nar)-32.9(asak)-17(a)]TJ /Span<>> BDC ( )Tj EMC [(T, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Mul)56(t)-32(icenter p)25(r)-32(opensi)-24(t)-10(y )]TJ 0.28 Tw -1.796 -1.25 Td [(scor)-24(e-ma)15.1(tched anal)35(y)-13(sis com)10(p)32(ar)-37(ing shor)-21.9(t )]TJ /T1_1 1 Tf 0 Tw [(v)13(ersus)]TJ /T1_0 1 Tf 0.28 Tw [( l)30(ong cap-assisted )]TJ 0.006 Tw T* [(col)30(onoscopy for a)-17(cute hema)15(t)17(o)-16(chezia. )]TJ /T1_1 1 Tf (JGH Open)Tj /T1_0 1 Tf (. 2023;7\(7\):487\226496. )Tj 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1002/jgh3.12936)Tj 0 0 0 1 k /GS1 gs 0.183 Tw -1.847 -1.25 Td (33.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Oza)10(w)-12(a)]TJ /Span<>> BDC ( )Tj EMC [(N, Y)50(ama)-24(zak)-15.9(i)]TJ /Span<>> BDC ( )Tj EMC (K, Hasebe)Tj /Span<>> BDC ( )Tj EMC [(N, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. End)-16(oscopic band l)-30.9(iga)]TJ 0 Tw (-)Tj 0.009 Tc 0.35 Tw -1.796 -1.25 Td [(t)-32.2(ion al)29.8(one and combined wi)-24.2(t)-13.2(h cl)-31.2(ipping for col)29.8(onic di)-16.2(ver)-22.2(t)-32.2(icu)]TJ 0 Tc 0 Tw (-)Tj 0.285 Tw T* [(l)-16(ar bleeding: R)13(e)-12(tr)-32(ospec)-15.9(t)-32(i)-16(ve com)10(p)32(ar)-33(a)15(t)-32(i)-16(ve stud)17(y. )]TJ /T1_1 1 Tf (Endosc Int Open)Tj /T1_0 1 Tf 0 Tw (. )Tj 0.023 Tw T* [(2025;13:a25367884. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1055/a-2536-7884)Tj 0 0 0 1 k /GS1 gs -0.004 Tw T* (34.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Kishino)Tj /Span<>> BDC ( )Tj EMC [(T, Sa)9.9(w)-11.9(a)]TJ /Span<>> BDC ( )Tj EMC [(T, T)60(suchihashi)]TJ /Span<>> BDC ( )Tj EMC [(T. Successful hemost)15(asis of)]TJ /Span<>> BDC ( )Tj EMC [(col)30(on)]TJ 0 Tw (-)Tj 0.004 Tw -1.796 -1.25 Td [(ic di)-16(ver)-22(t)-32(icul)-15.9(ar bleeding using single-ball)30(o)-16(on-assisted end)-16(oscopy and )]TJ 0.033 Tw T* [(end)-16(oscopic band l)-31(iga)15(t)-32(ion in a)]TJ /Span<>> BDC ( )Tj EMC [(p)32(a)15(t)-32(ient wi)-23.9(t)-13(h dif)-56(f)-28(icul)56(t t)17(o)17(t)15(al col)30(onosco)]TJ 0 Tw (-)Tj T* (py. )Tj /T1_1 1 Tf 1.499 0 Td [(Endoscop)12.1(y.)]TJ /T1_0 1 Tf 0.023 Tw [( 2025; 57\(S 01\):E56\226E57. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1055/a-2512-0667)Tj 0 0 0 1 k /GS1 gs 0.031 Tw -1.499 -1.25 Td (35.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Kishino)Tj /Span<>> BDC ( )Tj EMC [(T, Ki)-24(t)15.1(amur)-33(a)]TJ /Span<>> BDC ( )Tj EMC [(Y, Okud)42(a)]TJ /Span<>> BDC ( )Tj EMC [(T, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Useful tr)-23.9(ea)15(tment selec)-16(t)-32(ion )]TJ 0.099 Tw -1.796 -1.25 Td [(str)-33(a)15.1(teg)16(y )0.5(for )0.6(end)-16(oscopic )0.6(hemost)15(asis )0.6(in )0.5(col)30(onic )0.6(di)-16(ver)-22(t)-31.9(icul)-16(ar )0.6(bleeding )]TJ 0.236 Tw T* [(a)-17(ccor)-24(ding )0.5(t)17(o)]TJ /Span<>> BDC ( )Tj EMC 5.763 0 Td [(end)-16(oscopic )0.5(f)-28(indings )0.5(\(wi)-23.9(t)-13(h )0.5(v)-16(ideo\). )]TJ /T1_1 1 Tf 14.807 0 Td [(Endosc )0.5(Int )0.5(Open)]TJ /T1_0 1 Tf 0 Tw (. )Tj 0.023 Tw -20.57 -1.25 Td [(2025;13:a24711016. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1055/a-2471-1016)Tj 0 0 0 1 k /GS1 gs 0.117 Tw T* (36.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Y)50(amamo)17(t)17(o)]TJ /Span<>> BDC ( )Tj EMC [(K, S)-16(hir)-33(a)15.1(t)17(or)-37(i)]TJ /Span<>> BDC ( )Tj EMC [(Y, Ik)10(e)-11(y)22(a)]TJ /Span<>> BDC ( )Tj EMC [(T. Ut)-32(il)-31(i)-24(t)-9.9(y of)]TJ /Span<>> BDC ( )Tj EMC [(t)-13(he Gel Immer)-10(sion )]TJ 0.343 Tw -1.796 -1.25 Td [(Me)-12(t)-13(hod for T)50(r)-23.9(ea)15(t)-32(ing Massi)-16(ve Col)30(onic Di)-15.9(ver)-22(t)-32(icul)-15.9(ar Bleeding. )]TJ /T1_1 1 Tf 0 Tw (Clin )Tj T* (Endosc.)Tj /T1_0 1 Tf 0.023 Tw [( 2021;54\(2\):256\226260. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.5946/ce.2020.081)Tj 0 0 0 1 k /GS1 gs -0.014 Tw T* (37.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Sut)17(o)]TJ /Span<>> BDC ( )Tj EMC [(D, Y)40(oshid)42(a)]TJ /Span<>> BDC ( )Tj EMC [(M, Ot)15(ak)10(e)]TJ /Span<>> BDC ( )Tj EMC [(T, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. L)35(o)-16(cal)-31(izing spont)15(aneousl)35(y hemo)]TJ 0 Tw (-)Tj 0.192 Tw -1.796 -1.25 Td [(st)15(a)15(t)-32(ic col)30.1(onic di)-16(ver)-22(t)-31.9(icul)-16(ar bleeding using VISC)13(OCLEAR gel: A)]TJ /Span<>> BDC ( )Tj EMC (case )Tj 0.001 Tc -0.001 Tw T* [(r)-23.9(epor)-21.9(t. )]TJ /T1_1 1 Tf 0.349 Tw 3.383 0 Td (Ann Med Surg \(Lond\))Tj /T1_0 1 Tf [(. 2021;73:103141. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs -0.001 Tw (10.1016/j.)Tj 0 Tc 0 Tw -3.383 -1.25 Td (amsu.2021.103141)Tj 0 0 0 1 k /GS1 gs 0.123 Tw T* (38.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Y)50(aha)-17(gi)]TJ /Span<>> BDC ( )Tj EMC [(N, F)10(ujimo)17.1(t)17(o)]TJ /Span<>> BDC ( )Tj EMC [(A, Hor)-37(i)-15.9(i)]TJ /Span<>> BDC ( )Tj EMC [(J, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Dual r)-23.9(ed ima)-17(ging: a)]TJ /Span<>> BDC ( )Tj EMC (novel )Tj 0.006 Tc 0.35 Tw -1.796 -1.25 Td [(end)-16(oscopic )0.5(ima)-17(ging )0.5(technol)30(o)-16(g)15.9(y )0.6(v)-16(isual)-31(izing )0.5(t)-13(hick )0.5(bl)30(o)-16(od )0.5(vessels)6.1( )]TJ 0 Tc 0.209 Tw T* [(in t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(gastr)-32(ointest)-31.9(inal w)-11.9(all. )]TJ /T1_1 1 Tf (Endosc Int Open)Tj /T1_0 1 Tf (. 2019;7\(12\):E1632\226)Tj 0.023 Tw T* [(E1635. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1055/a-0749-0075)Tj 0 0 0 1 k /GS1 gs 0.031 Tw T* (39.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(F)10(ukud)42(a)]TJ /Span<>> BDC ( )Tj EMC [(S, Sak)-17(amo)17(t)17(o)]TJ /Span<>> BDC ( )Tj EMC [(T, Suzuk)-15.9(i)]TJ /Span<>> BDC ( )Tj EMC [(H, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Ut)-31.9(il)-31(i)-24(t)-10(y of)]TJ /Span<>> BDC ( )Tj EMC [(r)-24(ed dichr)-32(oma)15(t)-32(ic )]TJ 0.007 Tw -1.796 -1.25 Td [(ima)-17(ging for ident)-32(if)-34(ying t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(bleeding point in end)-16(oscopic hemost)15(asis )]TJ 0.343 Tw T* (of)Tj /Span<>> BDC ( )Tj EMC 1.391 0 Td [(col)30(onic )0.5(di)-16(ver)-21.9(t)-32(icul)-16(ar )0.5(bleeding. )]TJ /T1_1 1 Tf 13.128 0 Td (Video)Tj /Span<>> BDC ( )Tj EMC 2.722 0 Td (GIE)Tj /T1_0 1 Tf [(. )0.5(2022;7\(4\):149\226151. )]TJ 0 Tw -17.241 -1.25 Td [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td [(10.1016/j.v)-20.9(gie.2022.01.002)]TJ 0 0 0 1 k /GS1 gs -0.016 Tw -1.847 -1.25 Td (40.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Jensen)Tj /Span<>> BDC ( )Tj EMC 3.029 0 Td (DM, Ohning)Tj /Span<>> BDC ( )Tj EMC 4.733 0 Td [(GV, K)25.1(ov)-15(a)-17(cs)]TJ /Span<>> BDC ( )Tj EMC [(T)20(O, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. )0.5(Na)15(tur)-33(al )0.5(hist)17(or)-24(y )0.5(of)]TJ /Span<>> BDC ( )Tj EMC [(def)-28(ini)]TJ 0 Tw (-)Tj 0.189 Tw -9.558 -1.25 Td [(t)-32(i)-16(ve di)-15.9(ver)-22(t)-32(icul)-15.9(ar hemor)-24(r)-24(ha)-16.9(ge based on st)-32(igma)15(t)15(a of)]TJ /Span<>> BDC ( )Tj EMC [(r)-24(ecent hemor)]TJ 0 Tw 27.286 0 Td (-)Tj 0.325 Tw -27.286 -1.25 Td [(r)-24(ha)-17(ge and col)30(onoscopic Doppler bl)30.1(o)-16(od fl)30(o)-14(w moni)-23.9(t)17(or)-37(ing for r)-36.9(isk )]TJ 0.013 Tc 0.469 Tw T* [(str)-32.7(a)15.3(t)-31.8(if)-27.7(ica)15.3(t)-31.8(ion and def)-27.8(ini)-23.7(t)-31.7(i)-15.7(ve hemost)15.3(asis. )]TJ /T1_1 1 Tf (Gastrointest Endosc)Tj /T1_0 1 Tf 0 Tc 0 Tw (. )Tj 0.023 Tw T* [(2016;83\(2\):416\22623. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1016/j.gie.2015.07.033)Tj 0 0 0 1 k /GS1 gs 0.108 Tw T* (41.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Ogur)-37(i)]TJ /Span<>> BDC ( )Tj EMC 2.545 0 Td [(N, )0.6(Ik)10(e)-11(y)22(a)]TJ /Span<>> BDC ( )Tj EMC 3.63 0 Td [(T, )0.5(K)25(oba)15(y)22(ashi)]TJ /Span<>> BDC ( )Tj EMC 5.341 0 Td [(D, )0.5(e)-12(t)]TJ /Span<>> BDC ( )Tj EMC 2.253 0 Td [(al. )0.6(Ef)-56(fec)-16(t)-32(i)-16(veness )0.6(of)]TJ /Span<>> BDC ( )Tj EMC 8.297 0 Td [(r)-37(isk )0.6(scor)]TJ 0 Tw 3.423 0 Td (-)Tj 0.213 Tw -27.286 -1.25 Td [(ing sy)-12.9(stems in p)25(r)-24(edic)-16(t)-32(ing end)-16(oscopic tr)-23.9(ea)15(tment in col)30(onic di)-16(ver)]TJ 0 Tw 27.286 0 Td (-)Tj 0.009 Tc 0.349 Tw -27.286 -1.25 Td [(t)-31.7(icul)-15.7(ar bleeding. )]TJ /T1_1 1 Tf (J Gastroenterol Hepatol)Tj /T1_0 1 Tf [(. 2020;35\(5\):815\226820.)9( )]TJ 0 Tc 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1111/jgh.14901)Tj 0 0 0 1 k /GS1 gs 0.316 Tw -1.847 -1.25 Td (42.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Gobine)-12(t-Sugur)-31.9(o)]TJ /Span<>> BDC ( )Tj EMC [(M, Na)-17(ga)15(t)15.1(a)]TJ /Span<>> BDC ( )Tj EMC [(N, K)25(oba)15(y)22(ashi)]TJ /Span<>> BDC ( )Tj EMC [(K, e)-11.9(t)]TJ /Span<>> BDC ( )Tj EMC [(al. 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)0.6(\200\024\030\024\027\036\032\f\022\024\020\024 )0.5(\020\024\f\031\007\026\030\f\021\r\036\027\027\024\020\024 )0.5(\n\036\007\017)]TJ 0 Tw (-)Tj 0.331 Tw T* [(\006\017\027\f\022\024\020\024 )0.5(\031\027\017\r\036\030\f\017\021\036\021\026 )0.6(\017\n. )0.5(\203.\203. )0.6(\207\031\030\007\036\027\022\024; )0.5(ORCID )]TJ 0 Tw T* (0000-0001-9422-1776)Tj 0.24 Tw 0 -1.218 TD (\205\036\007\024\030\024\r \202\027\007\030\036\005 \200\035\026\007\017\ \n\017\030\024\r\017\004)Tj /Span<>> BDC ( )Tj EMC (\227 \007.\n.\027., \023\030\024\235\036\f)Tj 0 Tw (-)Tj 0.451 Tw 0 -1.218 TD (\f\024\030 \205\206\207\211 \253\203\026\006\017\024\027\026\035\034\027\ \t\005 \n\036\007\017\006\017\027\f\022\017\005 \017\f\f\035\036\007\024\ )Tj 0 Tw (-)Tj 0.223 Tw 0 -1.218 TD (\r\026\021\036\035\034\f\022\017\005 \006\036\027\021\030 \b\017\030\031\ \030\020\017\017 \017\n. \202.\200. \200\017\001\027\036\r\f\022\024\020\ \024\273 )Tj 0 Tw T* (\204\017\027\007\030\026\r\026 \217\024\f\f\017\017; ORCID 0000-0002-84\ 56-8685)Tj 0.193 Tw T* (\216\024\007\024\030\022\024\r\f\022\017\005 \204\026\030\022 \202\027\026\ \021\024\035\034\036\r\017\004)Tj /Span<>> BDC ( )Tj EMC (\227 \023\030\024\235\036\f\f\024\030 \022\026)Tj 0 Tw (-)Tj 0.638 Tw T* (\235\036\007\030\t \f\023\036\006\017\026\035\017\017\030\024\r\026\027\ \027\t\b \b\017\030\031\030\020\017\004\036\f\022\017\b \007\017\f)Tj 0 Tw (-)Tj 0.888 Tw T* (\006\017\023\035\017\027 \200\024\030\024\027\036\032\f\022\024\020\024 \ \020\024\f\031\007\026\030\f\021\r\036\027\027\024\020\024 \n\036\007\017\ )Tj 0 Tw (-)Tj 0.331 Tw T* [(\006\017\027\f\022\024\020\024 )0.5(\031\027\017\r\036\030\f\017\021\036\021\026 )0.6(\017\n. )0.5(\203.\203.)]TJ /Span<>> BDC ( )Tj EMC 14.82 0 Td [(\207\031\030\007\036\027\022\024; )0.6(ORCID )]TJ 0 Tw -14.82 -1.218 Td (0000-0003-2584-0471)Tj /T1_2 1 Tf 0.023 Tw 0 -2.436 TD (INFORMATION ABOUT THE)Tj /Span<>> BDC ( )Tj EMC (AUTHORS \(ORCID\))Tj /T1_1 1 Tf 0 Tw 0 -1.218 TD [(Vl)-16(adimir N. Ek)-23.9(t)17.1(ov)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0001-9422-1776)Tj T* [(Andr)-24(e)-10.9(y V. F)10(ed)-16(or)-32(ov)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0002-8456-8685)Tj T* [(Mar)-24(k A. Khod)-15.9(or)-24(kovsk)-31.9(y)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0003-2584-0471)Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 42.5896 359.4899 Tm [(\r\031\024\034\033)48(\026)45(\024)-10(\223\033)48(\026/REFERENCES)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0 Tc -0.008 Tw 8 0 0 8 42.5197 346.6552 Tm (1.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(P)30(eer)-23.9(y)]TJ /Span<>> BDC ( )Tj EMC [(AF, Cr)-32(o)-15.9(ck)10(e)-12(t)-30(t)]TJ /Span<>> BDC ( )Tj EMC [(SD, Bar)-23.9(r)-37(i)-24(t)-30(t)]TJ /Span<>> BDC ( )Tj EMC [(A)35(S, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Bur)-23.9(den of)]TJ /Span<>> BDC ( )Tj EMC [(gastr)-31.9(ointest)-32(inal, )]TJ 0.021 Tw -1.296 -1.25 Td [(l)-31(i)-16(ver, )0.5(and )0.5(p)32(ancr)-24(ea)15.1(t)-32(ic diseases )0.5(in )0.5(t)-13(he)]TJ /Span<>> BDC ( )Tj EMC 14.734 0 Td [(U)13(ni)-24(ted )0.5(S)15(t)15(a)15(tes. )]TJ /T1_3 1 Tf 0 Tw 5.966 0 Td (Gastroenterology)Tj /T1_1 1 Tf (. )Tj 0.023 Tw -20.7 -1.25 Td [(2015;149\(7\):1731\2261741.e3. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw [(10.1053/j.gastr)-31.9(o.2015.08.045)]TJ 0 0 0 1 k /GS1 gs 0.163 Tw 0 -1.25 TD (2.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Whea)15(t)]TJ /Span<>> BDC ( )Tj EMC [(CL, S)15(tr)-32.9(a)14.9(te)]TJ /Span<>> BDC ( )Tj EMC [(LL. T)50(r)-24(ends in hospi)-24(t)15(al)-31(iza)15.1(t)-32(ion for di)-16(ver)-22(t)-31.9(icul)-31(i)-24(t)-32(is )]TJ 0.13 Tw -1.296 -1.25 Td [(and )0.5(di)-16(ver)-21.9(t)-32(icul)-16(ar )0.5(bleeding )0.5(in )0.6(t)-13(he)]TJ /Span<>> BDC ( )Tj EMC 13.648 0 Td [(U)13(ni)-24(ted )0.5(S)15(t)15(a)15(tes )0.6(fr)-32(om )0.5(2000 )0.5(t)17(o)]TJ /Span<>> BDC ( )Tj EMC 11.693 0 Td (2010. )Tj /T1_3 1 Tf 0.212 Tw -25.342 -1.25 Td [(Clin Gastroenterol )0.5(Hepatol.)]TJ /T1_1 1 Tf [( 2016;14\(1\):96\226103.e1. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1016/j.)Tj T* (cgh.2015.03.030)Tj 0 0 0 1 k /GS1 gs 0.004 Tc 0.349 Tw T* (3.)Tj /Span<>> BDC ( )Tj EMC 1.307 0 Td (Kinjo)Tj /Span<>> BDC ( )Tj EMC [(K, Ma)15.2(tsui)]TJ /Span<>> BDC ( )Tj EMC (T, Hisabe)Tj /Span<>> BDC ( )Tj EMC [(T, Ishihar)-32.7(a)]TJ /Span<>> BDC ( )Tj EMC [(H, e)-11.8(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Incr)-23.8(ease in)4( )]TJ 0 Tc 0.179 Tw -1.307 -1.25 Td [(col)30(onic di)-16(ver)-22(t)-32(icul)-15.9(ar hemor)-23.9(r)-24(ha)-17(ge and confounding f)16(a)-17(c)-16(t)17.1(or)-10(s. )]TJ /T1_3 1 Tf [(W)29(orld J )]TJ 0.105 Tw T* [(Gastrointest Phar)-14(macol Ther.)]TJ /T1_1 1 Tf [( 2016;7\(3\):440\2266. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.4292/wjgpt.)Tj T* (v7.i3.440)Tj 0 0 0 1 k /GS1 gs 0.133 Tw T* (4.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Ichi)-24(t)15(a)]TJ /Span<>> BDC ( )Tj EMC [(C, Go)17(t)17(o)]TJ /Span<>> BDC ( )Tj EMC [(T, Sasak)-16(i)]TJ /Span<>> BDC ( )Tj EMC [(A, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Na)15(t)-32(ional tr)-23.9(ends in hospi)-23.9(t)15(al)-31(iza)]TJ 0 Tw (-)Tj 0.19 Tw -1.296 -1.25 Td [(t)-32(ions for gastr)-32(ointest)-31.9(inal bleeding in Jap)32(an. )]TJ /T1_3 1 Tf [(J Clin Biochem N)21(utr.)]TJ /T1_1 1 Tf 0 Tw ( )Tj 0.023 Tw T* [(2024;75\(1\):60\22664. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.3164/jcbn.23-111)Tj 0 0 0 1 k /GS1 gs -0.021 Tw T* (5.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (Amano)Tj /Span<>> BDC ( )Tj EMC [(H, Y)50(amamo)17(t)17(o)]TJ /Span<>> BDC ( )Tj EMC [(T, Ikusak)-16.9(a)]TJ /Span<>> BDC ( )Tj EMC [(K, e)-11.9(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Cl)-31(inical F)20(a)-17(c)-16(t)17(or)-9.9(s Asso)-16(c)-24(ia)15(ted )]TJ -0.034 Tw -1.296 -1.25 Td [(wi)-24(t)-13(h Sever)-36.9(i)-24(t)-10(y of)]TJ /Span<>> BDC ( )Tj EMC [(Col)30(onic Di)-16(ver)-21.9(t)-32(icul)-16(ar Bleeding and Im)10(p)32(a)-17(c)-16(t of)]TJ /Span<>> BDC ( )Tj EMC (Bleeding )Tj 0 Tw T* [(S)-16(i)-24(te. )]TJ /T1_3 1 Tf 0.023 Tw 2.153 0 Td (J Clin Med.)Tj /T1_1 1 Tf [( 2023;12\(5\):1826. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.3390/jcm12051826)Tj 0 0 0 1 k /GS1 gs 0.01 Tw -2.153 -1.25 Td (6.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(K)-16(aise)]TJ /Span<>> BDC ( )Tj EMC [(M, Na)-17(ga)15(t)15(a)]TJ /Span<>> BDC ( )Tj EMC [(N, Ishi)-16(i)]TJ /Span<>> BDC ( )Tj EMC [(N, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Epidemiol)30(o)-16(g)16(y of)]TJ /Span<>> BDC ( )Tj EMC [(col)30(onic di)-16(ver)-21.9(t)-32(ic)]TJ 0 Tw (-)Tj 0.08 Tw -1.296 -1.25 Td [(ul)-16(a and r)-24(ecent ad)-17(v)-14.9(ances in t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(mana)-17(gement of)]TJ /Span<>> BDC ( )Tj EMC [(col)30(onic di)-16(ver)-22(t)-31.9(icul)-16(ar )]TJ 0 Tw T* (bleeding. )Tj /T1_3 1 Tf 0.019 Tw 4.039 0 Td (Dig Endosc.)Tj /T1_1 1 Tf [( 2020;32\(2\):240\226250. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1111/den.13547)Tj 0 0 0 1 k /GS1 gs 0.215 Tw -4.039 -1.25 Td (7.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(T)40(ak)-16(i)]TJ /Span<>> BDC ( )Tj EMC (M, Oshima)Tj /Span<>> BDC ( )Tj EMC [(T, T)45(oza)10(w)-12(a)]TJ /Span<>> BDC ( )Tj EMC [(K, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Anal)35(y)-13(sis of)]TJ /Span<>> BDC ( )Tj EMC [(r)-37(isk f)16.1(a)-17(c)-16(t)17(or)-10(s for )]TJ 0.103 Tw -1.296 -1.25 Td [(col)30(onic di)-16(ver)-22(t)-32(icul)-15.9(ar bleeding and r)-24(ecur)-23.9(r)-24(ence. )]TJ /T1_3 1 Tf (Medicine \(Baltimore\))Tj /T1_1 1 Tf 0 Tw (. )Tj 0.023 Tw T* [(2017;96\(38\):e8090. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1097/MD.0000000000008090)Tj 0 0 0 1 k /GS1 gs 0.104 Tw T* (8.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Ok)-17(ad)42(a)]TJ /Span<>> BDC ( )Tj EMC 2.741 0 Td [(T, Mik)-16.9(amo)]TJ /Span<>> BDC ( )Tj EMC [(T, )0.5(Nak)-17(ashima)]TJ /Span<>> BDC ( )Tj EMC 10.082 0 Td [(A, )0.5(e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. )0.5(Constr)-21.9(uc)-16(t)-32(ion of)]TJ /Span<>> BDC ( )Tj EMC 10.303 0 Td (a)Tj /Span<>> BDC ( )Tj EMC 0.8 0 Td [(M)-24(odel )]TJ 0.215 Tw -25.221 -1.25 Td [(for P)35(r)-24(edic)-16(t)-32(ing t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(Sever)-37(i)-23.9(t)-10(y of)]TJ /Span<>> BDC ( )Tj EMC [(Di)-16(ver)-21.9(t)-32(icul)-16(ar Bleeding in an)]TJ /Span<>> BDC ( )Tj EMC [(Elder)-29.9(l)35(y )]TJ 0.003 Tc -0.003 Tw T* [(P)10.3(opul)-15.7(a)15.2(t)-31.7(ion. )]TJ /T1_3 1 Tf 0.349 Tw 5.337 0 Td [(Inter)-13.7(n Med.)]TJ /T1_1 1 Tf [( 2022;61\(15\):2247\2262253. d)-15.7(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs -0.003 Tw (10.2169/)Tj 0 Tc 0 Tw -5.337 -1.25 Td [(inter)-15(nalmedic)-23.9(ine.8761-21)]TJ 0 0 0 1 k /GS1 gs 0.052 Tw 29.055 32.5 Td (9.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (Chang)Tj /Span<>> BDC ( )Tj EMC [(LS, Nishid)42(a)]TJ /Span<>> BDC ( )Tj EMC [(T, Hosok)-16.9(a)10(w)-12(a)]TJ /Span<>> BDC ( )Tj EMC [(K, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Im)10(p)32(a)-17(c)-16(t of)]TJ /Span<>> BDC ( )Tj EMC [(ant)-32(icoa)-16.9(gul)-16(ants )]TJ 0.051 Tw -1.296 -1.25 Td [(on t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(cl)-30.9(inical outcomes of)]TJ /Span<>> BDC ( )Tj EMC [(col)30(onic di)-16(ver)-22(t)-32(icul)-15.9(ar bleeding com)10(p)32(ar)-36.9(ing )]TJ -0.005 Tw T* [(w)-12(ar f)16(ar in and dir)-23.9(ec)-16(t or)-33(al ant)-31.9(icoa)-17(gul)-16(ants. )]TJ /T1_3 1 Tf [(Sci R)21.1(ep.)]TJ /T1_1 1 Tf ( 2022;12\(1\):16795. )Tj 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1038/s41598-022-21166-8)Tj 0 0 0 1 k /GS1 gs -0.141 Tw -1.847 -1.25 Td (10.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (\221\036\035\t\020\017\027)Tj /Span<>> BDC ( )Tj EMC (\222.\202., \236\r\026\001\022\017\027)Tj /Span<>> BDC ( )Tj EMC (\200.\230., \202\004\022\026\f\024\r)Tj /Span<>> BDC ( )Tj EMC (\224.\236., \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. \025\035\017\027\017\004\036\f\022\017\036 )Tj 0.22 Tw -1.796 -1.25 Td (\030\036\022\024\n\036\027\007\026\006\017\017. \212\017\r\036\030\021\017\ \022\031\035\016\030\027\026\016 \002\024\035\036\027\034 \(\02557.2, \025\ 57.3\), \r\030\024\f)Tj 0 Tw (-)Tj T* (\035\t\036. )Tj /T1_3 1 Tf 2.394 0 Td (\r\034\027\034\f\033\034\021\035\034\027\034\013\022\030)Tj /T1_1 1 Tf 0.307 Tw [(. 2024;23\(2\):10\22627. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.33878/2073-)Tj -2.394 -1.25 Td (7556-2024-23-2-10-27)Tj 0 0 0 1 k /GS1 gs 0.064 Tw [( / S)-16(hel)35(ygin)]TJ /Span<>> BDC ( )Tj EMC [(Y.A., Iv)-15(ashk)-16(in)]TJ /Span<>> BDC ( )Tj EMC [(V.T., A)-25(chk)-17(asov)]TJ /Span<>> BDC ( )Tj EMC (S.I., )Tj 0.16 Tw T* [(e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Cl)-30.9(inical guidel)-31(ines. Di)-16(ver)-22(t)-31.9(icul)-16(ar disease \(57.2, 57.3\), adul)56(ts. )]TJ /T1_3 1 Tf 0 Tw T* [(K)18(olop)46(roktologia)]TJ /T1_1 1 Tf 0.02 Tw [(. 2024;23\(2\):10\22627. )0.5(\(In Russ.\). d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.33878/2073-)Tj T* (7556-2024-23-2-10-27)Tj 0 0 0 1 k /GS1 gs 0.132 Tw T* (11.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(L)-32(aine)]TJ /Span<>> BDC ( )Tj EMC [(L, S)-16(hah)]TJ /Span<>> BDC ( )Tj EMC [(A. R)-9.9(and)-16(omized tr)-37(ial of)]TJ /Span<>> BDC ( )Tj EMC [(ur)-32(gent vs. elec)-15.9(t)-32(i)-16(ve col)30(o)]TJ 0 Tw (-)Tj 0.312 Tw -1.796 -1.25 Td [(noscopy in p)32(a)15(t)-32(ients hospi)-23.9(t)15(al)-31(ized wi)-23.9(t)-13(h l)30(o)-14(wer GI bleeding. )]TJ /T1_3 1 Tf (Am J )Tj 0.002 Tc -0.002 Tw T* (Gastroenterol. )Tj /T1_1 1 Tf 0.35 Tw 6.169 0 Td [(2010;105\(12\):2636\22641; quiz 2642. d)-16.2(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs -0.002 Tw (10.1038/)Tj 0 Tc 0 Tw -6.169 -1.25 Td (ajg.2010.277)Tj 0 0 0 1 k /GS1 gs 0.328 Tw T* (12.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Na)-17(ga)15(t)15(a)]TJ /Span<>> BDC ( )Tj EMC [(N, Ishi)-15.9(i)]TJ /Span<>> BDC ( )Tj EMC (N, Manabe)Tj /Span<>> BDC ( )Tj EMC [(N, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Guidel)-30.9(ines for Col)30(onic )]TJ 0.025 Tc 0.881 Tw -1.796 -1.25 Td [(D)0.5(i)-15.5(v)0.5(e)0.5(r)-21.5(t)-31.5(i)0.5(c)0.5(u)0.5(l)-15.5(a)0.5(r)0.5( B)0.5(l)0.5(e)0.5(e)0.5(d)0.5(i)0.5(ng)0.5( a)0.5(n)0.5(d)0.5( C)0.5(o)0.5(l)30.5(o)0.5(n)0.5(i)0.5(c)0.5( D)0.5(i)-15.5(v)0.5(e)0.5(r)-21.5(t)-31.5(i)0.5(c)0.5(u)0.5(l)-30.5(i)-23.5(t)-31.5(i)0.5(s)0.5(:)0.5( J)0.5(a)0.5(p)32.5(a)0.5(n)25( )]TJ 0 Tc 0.279 Tw T* [(Gastr)-32(oenter)-31.9(ol)30(o)-16(gical Asso)-16(c)-24(ia)15(t)-32(ion. )]TJ /T1_3 1 Tf 0 Tw [(Dig)12(estion.)]TJ /T1_1 1 Tf 0.279 Tw ( 2019;99Suppl 1:1\22626. )Tj 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1159/000495282)Tj 0 0 0 1 k /GS1 gs 0.103 Tw -1.847 -1.25 Td (13.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Z)-16(ia Z)-16(iabar)-37(i)]TJ /Span<>> BDC ( )Tj EMC [(SM, R)-24(ima)-24(z)]TJ /Span<>> BDC ( )Tj EMC [(S, S)-16(haf)16(a)-17(ghi)]TJ /Span<>> BDC ( )Tj EMC [(A, e)-11.9(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Bl)30(o)-16(od ur)-24(ea ni)-24(tr)-31.9(o)-16(gen )]TJ 0.011 Tw -1.796 -1.25 Td [(t)17(o)]TJ /Span<>> BDC ( )Tj EMC [(cr)-23.9(ea)15(t)-32(inine r)-33(a)15(t)-32(io in dif)-56(fer)-23.9(ent)-32(ia)15(t)-32(ion of)]TJ /Span<>> BDC ( )Tj EMC [(upper and l)30(o)-14(wer gastr)-31.9(ointes)]TJ 0 Tw (-)Tj 0.079 Tw T* [(t)-32(inal bleedings; a)]TJ /Span<>> BDC ( )Tj EMC [(dia)-17(gnost)-32(ic a)-17(ccur)-33(a)-17(cy stud)17.1(y. )]TJ /T1_3 1 Tf (Arch Acad Emerg Med.)Tj /T1_1 1 Tf 0 Tw ( )Tj T* (2019;7\(1\):e30.)Tj 0.093 Tw T* (14.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(T)45(omiza)10(w)-12(a)]TJ /Span<>> BDC ( )Tj EMC [(M, S)-16(hinozak)-16(i)]TJ /Span<>> BDC ( )Tj EMC [(F, Hasega)10(w)-12(a)]TJ /Span<>> BDC ( )Tj EMC [(R, e)-11.9(t)]TJ /Span<>> BDC ( )Tj EMC [(al. 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\r\f\023\024\n\024\020\026\021\036\035\034\027\024\020\ \024 \007\017\026\020\027\024\f\021\017\004\036\f\022\024\020\024 \n\036\ \021\024\007\026 )Tj 0 Tw 0 -1.218 TD (\023\036\030\036\007 \r\t\023\024\035\027\036\027\017\036\n \022\024\035\ \024\027\024\f\022\024\023\017\017.)Tj 0.248 Tw 0 -1.218 TD (\225\235\235\036\022\021\017\r\027\024\f\021\034 \023\030\017\n\036\027\036\ \027\017\016 \f\036\035\036\022\021\017\r\027\024\005 \026\027\020\017\024\ \020\030\026)Tj 0 Tw (-)Tj 0.319 Tw 0 -1.218 TD (\235\017\017 \007\035\016 \023\036\030\r\017\004\027\024\005 \007\017\026\ \020\027\024\f\021\017\022\017 \212\230\025 \024\020\030\026\027\017\004\ \036\027\026, )Tj 0.199 Tw T* (\023\024\f\022\024\035\034\022\031 \007\035\016 \r\t\016\r\035\036\027\017\ \016 \220\022\f\021\030\026\r\026\026\006\017\017 \017\027\021\036\030\r\ \036\027)Tj 0 Tw (-)Tj 0.864 Tw T* (\006\017\024\027\027\024-\030\026\007\017\024\035\024\020\017\004\036\f\022\ \017\n \n\036\021\024\007\024\n \017\f\f\035\036\007\024\r\026\027\017\016\ )Tj 0.307 Tw T* (\021\030\036\002\031\036\021\f\016 \007\024\f\021\026\021\024\004\027\024\ \r\t\f\024\022\026\016 \f\022\024\030\024\f\021\034 \026\022\021\017\r\027\ \024\020\024 )Tj 0.079 Tw T* (\022\030\024\r\024\021\036\004\036\027\017\016)Tj /Span<>> BDC ( )Tj EMC (\227 \024\021 0,5 \007\024)Tj /Span<>> BDC ( )Tj EMC (1,0)Tj /Span<>> BDC ( )Tj EMC (\n\035/\n\017\027, \r)Tj /Span<>> BDC ( )Tj EMC (\f\r\016\017 \f)Tj /Span<>> BDC ( )Tj EMC (\004\036\n )Tj 0.343 Tw T* (\026\027\020\017\024\020\030\026\235\017\016 \n\024\032\036\021 \030\026\ \f\f\n\026\021\030\017\r\026\021\034\f\016 \022\026\022 \220\022\f\021\030\ \036\027)Tj 0 Tw (-)Tj 0.534 Tw T* (\027\t\005 \r\026\030\017\026\027\021 \007\017\026\020\027\024\f\021\017\ \022\017 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\007\024\035\032\026\033\013\036\n\f\016 )Tj 0.044 Tw T* (\022\030\024\r\024\021\036\004\036\027\017\017, \023\024\r\024\035\016\033\ \013\017\005 \r\t\016\r\017\021\034 \220\022\f\021\030\026\r\026\026\006\ \017\033 )Tj 0.449 Tw T* (\023\030\017\n\036\030\027\024 \031)Tj /Span<>> BDC ( )Tj EMC (85% \020\036\n\024\007\017\027\026\n\017\004\036\f\022\017 \027\036\f\021\ \026\002\017\035\034\027\t\b )Tj 0.142 Tw T* (\023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\f\017\f\021\024\035\017\004\036\f\022\017\n \026\030\021\036\030\017\026\ \035\034\027\t\n \007\026\r\035\036\027\017)Tj 0 Tw (-)Tj 0.007 Tw T* (\036\n)Tj /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (90)Tj /Span<>> BDC ( )Tj EMC (\n\n \030\021.)Tj /Span<>> BDC ( )Tj EMC (\f\021., \022\024\021\024\030\t\n \021\030\036\002\024\r\026\035\024\f\034\ \023\036\030\036\035\017\r\026\027\017\036 )Tj 0.068 Tw T* (\027\036 \n\036\027\036\036 5 \036\007\017\027\017\006 \220\030\017\021\030\ \024\006\017\021\026\030\027\024\005 \n\026\f\f\t \r)Tj /Span<>> BDC ( )Tj EMC (\021\036\004\036\027\017\036 )Tj 0.084 Tw T* (24)Tj /Span<>> BDC ( )Tj EMC (\004\026\f\024\r [50]. \215\030\017)Tj /Span<>> BDC ( )Tj EMC (\017\031\004\036\027\017\017 \220\235\235\036\022\021\017\r\027\024\f\021\ \017 \023\030\017\n\036)Tj 0 Tw (-)Tj 0.268 Tw T* (\027\036\027\017\016 \021\030\026\027\f\022\026\021\036\021\036\030\027\024\ \005 \026\030\021\036\030\017\026\035\034\027\024\005 \220\n\002\024\035\ \017\026\006\017\017 )Tj -0.013 Tw T* (\(\230\202\213\) \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\212\230\025 \f)Tj /Span<>> BDC ( )Tj EMC (\220\022\f\021\030\026\r\026\026\006\017\036\005 \027\026)Tj /Span<>> BDC ( )Tj EMC (\022\024\n\023\034\033\021\036\030\027\024\005 \021\024)Tj 0 Tw (-)Tj 0.094 Tw T* (\n\024\020\030\026\235\017\017 \002\t\035\024 \031\f\021\026\027\024\r\035\ \036\027\024, \004\021\024 \004\026\f\021\024\021\026 \r\t\016\r\035\036\ \027\017\016 )Tj 0.02 Tw T* (\024\004\026\020\024\r \022\030\024\r\024\021\036\004\036\027\017\016 \002\ \t\035\026 \027\026\004\017\021\036\035\034\027\024 \r\t\001\036 \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023)Tj 0 Tw (-)Tj 0.156 Tw T* [(\023\036 T)35(AE \(89,74%,\), \004\036\n \r)]TJ /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \f\030\024\004\027\024\005 \022\024\035\024\027\ \024\f\022\024)Tj 0 Tw (-)Tj 0.031 Tw T* (\023\017\017 \(37,30%; P)Tj /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (0,001\), \026)Tj /Span<>> BDC ( )Tj EMC (\004\026\f\021\024\021\026 \023\024\r\021\024\030\027\024\020\024 \022\030\ \024\r\024)Tj 0 Tw (-)Tj 0.13 Tw T* (\021\036\004\036\027\017\016 \002\t\035\026 \027\026\004\017\021\036\035\ \034\027\024 \027\017\032\036 \r)Tj /Span<>> BDC ( )Tj EMC [(\020\030\031\023\023\036 T)35(AE \(0%\), )]TJ 0.025 Tw T* (\004\036\n \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \031\f\023\036\001\027\024\020\024 \220\027\007\ \024\f\022\024\023\017\004\036\f\022\024\020\024 \020\036\n\024\f\021\026\ \026 )Tj 0.172 Tw T* (\(23,91%; \217)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,005\). \215\030\017)Tj /Span<>> BDC ( )Tj EMC (\r\t\023\024\035\027\036\027\017\017 \007\017\026\020\027\024\f\021\017\004\ \036)Tj 0 Tw (-)Tj 0.093 Tw T* (\f\022\024\005 \026\027\020\017\024\020\030\026\235\017\017 \f\027\026\004\ \026\035\026 \017\f\f\035\036\007\031\036\021\f\016 \r\036\030\b\027\016\ \016 \017\035\017 )Tj 0.092 Tw T* (\027\017\032\027\016\016 \002\030\t\032\036\036\004\027\026\016 \026\030\ \021\036\030\017\017, \026)Tj /Span<>> BDC ( )Tj EMC (\036\f\035\017 \n\036\f\021\024 \022\030\024\r\024\021\036)Tj 0 Tw (-)Tj -0.017 Tw T* (\004\036\027\017\016 \027\036 \031\007\026\036\021\f\016 \024\023\030\036\ \007\036\035\017\021\034, \021\024 \023\030\024\017\r\024\007\017\021\f\ \016 \f\031\023\036\030)Tj 0 Tw (-)Tj 0.121 Tw T* (\f\036\035\036\022\021\017\r\027\026\016 \026\027\020\017\024\020\030\026\ \235\017\016 \r\036\021\r\036\005 \r\036\030\b\027\036\005 \017)Tj /Span<>> BDC ( )Tj EMC (\027\017\032\027\036\005 )Tj 0.169 Tw T* (\002\030\t\032\036\036\004\027\t\b \026\030\021\036\030\017\005 \(\023\024\ \007\r\007\024\001\027\024-\024\002\024\007\024\004\027\024\005, \023\030\ \026)Tj 0 Tw (-)Tj 0.188 Tw T* (\r\024\005 \024\002\024\007\024\004\027\024\005, \f\030\036\007\027\036\005\ \024\002\024\007\024\004\027\024\005 \017)Tj /Span<>> BDC ( )Tj EMC (\f\017\020\n\024\r\017\007\027\024\005 )Tj 0.232 Tw T* (\026\030\021\036\030\017\005\) [51,52]. \200)Tj /Span<>> BDC ( )Tj EMC (\023\024\f\035\036\007\027\036\036 \r\030\036\n\016 \023\030\036\007\035\ \026\020\026\036\021\f\016 )Tj 0.32 Tw T* (\023\030\017\n\036\027\036\027\017\036 \026\027\020\017\024\020\030\026\235\ \017\017 \f)Tj /Span<>> BDC ( )Tj EMC [(C)13(O)]TJ 0 Tw 5.83 0 0 5.83 206.2532 199.1758 Tm (2)Tj /Span<>> BDC ( )Tj EMC 0.32 Tw 10 0 0 10 212.3938 201.1758 Tm (\227 \031\f\017\035\036\027\017\036\n \007\035\016 )Tj 0.272 Tw -14.153 -1.218 Td [(\007\017\026\020\027\024\f\021\017\022\017 )0.6(\007\017\r\036\030\021\017\022\031\035\016\030\027\t\b )0.5(\022\030\024\r\024\021\036\004\036\027\017\005, )0.6(\022\024\021\024)]TJ 0 Tw (-)Tj 0.287 Tw T* [(\030\t\036 )0.5(\027\036 )0.5(\024\002\027\026\030\031\032\017\r\026\033\021\f\016 )0.5(\023\030\017)]TJ /Span<>> BDC ( )Tj EMC 13.166 0 Td [(\017\f\023\024\035\034\024\r\026\027\017\017 )0.6(\f\021\026\027)]TJ 0 Tw (-)Tj -0.04 Tw -13.166 -1.218 Td (\007\026\030\021\027\024\005 \026\027\020\017\024\020\030\026\235\017\017\ \f)Tj /Span<>> BDC ( )Tj EMC (\005\024\007\f\024\007\036\030\032\026\013\017\n \022\024\027\021\030\026\ \f\021\027\t\n )Tj 0.172 Tw 0 -1.218 TD (\r\036\013\036\f\021\r\024\n \(ICM\). \225\235\235\036\022\021\017\r\027\ \024\f\021\034 \r\t\016\r\035\036\027\017\016 \026\022\021\017\r)Tj 0 Tw (-)Tj 0.509 Tw 0 -1.218 TD (\027\024\020\024 \022\030\024\r\024\021\036\004\036\027\017\016 \f)Tj /Span<>> BDC ( )Tj EMC [(\023\024\n\024\013\034\033 C)13(O)]TJ 0 Tw 5.83 0 0 5.83 229.6944 138.2858 Tm (2)Tj 10 0 0 10 232.6094 140.2858 Tm (-\026\027\020\017\024\020\030\026\235\017\017, )Tj 0.501 Tw -16.174 -1.218 Td [(\022\024\021\024\030\024\036 )0.5(\027\036 \002\t\035\024 )0.5(\031\f\021\026\027\024\r\035\036\027\024 )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC [(\023\024\n\024\013\034\033 )0.5(ICM-)]TJ 0.35 Tw T* (\026\027\020\017\024\020\030\026\235\017\017, \f\024\f\021\026\r\035\016\ \036\021 48%. \232\026\f\021\024\021\026 \030\036\006\017\007\017\r\024\r\ )Tj 0.016 Tw T* (\022\030\024\r\024\021\036\004\036\027\017\016 \024\021\n\036\004\036\027\ \026 \031)Tj /Span<>> BDC ( )Tj EMC (23% \002\024\035\034\027\t\b \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 ICM-)Tj -0.038 Tw T* [(\026\027\020\017\024\020\030\026\235\017\017 )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC 6.306 0 Td [(6,9% )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 2.807 0 Td [(\020\030\031\023\023\036 )0.6(C)12.9(O)]TJ 0 Tw 5.83 0 0 5.83 201.8997 89.5738 Tm (2)Tj -0.038 Tw 10 0 0 10 204.8147 91.5738 Tm [(-\026\027\020\017\024\020\030\026\235\017\017. )0.6(\230\026\022\017\n )]TJ 0.529 Tw -13.395 -1.218 Td (\024\002\030\026\024\n, \023\030\017\n\036\027\036\027\017\036 \224\210\ )Tj 0 Tw 5.83 0 0 5.83 183.2115 77.3958 Tm (2)Tj 0.529 Tw 10 0 0 10 186.1265 79.3958 Tm (-\026\027\020\017\024\020\030\026\235\017\017 \023\024\r\t\001\026\036\021\ )Tj 0.376 Tw 11.718 64.543 Td (\220\235\235\036\022\021\017\r\027\024\f\021\034 \007\017\026\020\027\024\ \f\021\017\022\017 \017)Tj /Span<>> BDC ( )Tj EMC (\035\036\004\036\027\017\016 \212\230\025 [53]. )Tj 0.055 Tw 0 -1.218 TD [(\203\036\007\024\f\021\026\021\022\026\n\017 \026\027\020\017\024\020\030\ \026\235\017\017 )0.5(\016\r\035\016\033\021\f\016 \024\021\f\031\021\f\021\r\017\036 \001\017\ )]TJ 0 Tw (-)Tj 0.118 Tw 0 -1.218 TD (\030\024\022\017\b \r\024\n\024\032\027\024\f\021\036\005 \036\036 \023\ \030\017\n\036\027\036\027\017\016 \017)Tj /Span<>> BDC ( )Tj EMC (\027\017\022\026\016 \r\036\030\024)Tj 0 Tw (-)Tj 0.351 Tw 0 -1.218 TD [(\016\021\027\024\f\021\034 )0.6(\023\024\035\024\032\017\021\036\035\034\027\024\020\024 )0.5(\030\036\031\035\034\021\026\021\026 )0.6(\024\002\f\035\036\007\024\r\026\027\017\016, )]TJ 0.031 Tw 0 -1.218 TD (\023\024\f\022\024\035\034\022\031 \024\027\026 \023\024\r\024\035\016\036\ \021 \r\t\016\r\017\021\034 \024\004\026\020 \022\030\024\r\024\021\036\004\ \036\027\017\016 )Tj -0.034 Tw 0 -1.218 TD [(\n\036\027\036\036 )0.5(\004\036\n )0.6(\031)]TJ /Span<>> BDC ( )Tj EMC 5.031 0 Td [(25% )0.5(\023\026\006\017\036\027\021\024\r )0.6(\f)]TJ /Span<>> BDC ( )Tj EMC 7.113 0 Td [(\021\016\032\036\035\t\n\017 )0.6(\021\024\035\f\021\024\022\017\001\036\004)]TJ 0 Tw (-)Tj 0.06 Tw -12.145 -1.218 Td (\027\t\n\017 \022\030\024\r\024\021\036\004\036\027\017\016\n\017 \017)Tj /Span<>> BDC ( )Tj EMC (\n\036\027\036\036 \004\036\n \031)Tj /Span<>> BDC ( )Tj EMC (20% \023\026\006\017\036\027\021\024\r )Tj 0.106 Tw 0 -1.218 TD (\f)Tj /Span<>> BDC ( )Tj EMC (\022\024\035\024\027\024\f\022\024\023\017\004\036\f\022\017 \023\024\007\ \021\r\036\030\032\007\036\027\027\t\n \016\r\027\t\n \007\017\r\036\030\ )Tj 0 Tw (-)Tj 0.085 Tw T* [(\021\017\022\031\035\016\030\027\t\n )0.6(\022\030\024\r\024\021\036\004\036\027\017\036\n )0.6([21]. )0.5(\025\030\024\n\036 )0.5(\021\024\020\024, )0.6(\026\027\020\017\024)]TJ 0 Tw (-)Tj -0.044 Tw T* (\020\030\026\235\017\016 \016\r\035\016\036\021\f\016 \007\024\030\024\020\ \024\f\021\024\016\013\036\005 \023\030\024\006\036\007\031\030\024\005,\ \017)Tj /Span<>> BDC ( )Tj EMC (\036\036 \r\t)Tj 0 Tw (-)Tj 0.021 Tw T* (\023\024\035\027\036\027\017\036 \n\024\032\036\021 \023\030\017\r\036\f\ \021\017 \022)Tj /Span<>> BDC ( )Tj EMC (\f\036\030\034\036\027\t\n \024\f\035\024\032\027\036\027\017\016\n )Tj 0.088 Tw T* (\(\024\f\021\030\024\036 \023\024\r\030\036\032\007\036\027\017\036 \023\ \024\004\036\022, \026\035\035\036\030\020\017\004\036\f\022\017\036 \030\ \036\026\022\006\017\017 )Tj 0.209 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC (\022\024\027\021\030\026\f\021\027\t\036 \r\036\013\036\f\021\r\026, \020\ \036\n\026\021\024\n\t, \021\030\024\n\002\024 \026\030\021\036)Tj 0 Tw (-)Tj T* (\030\017\005, \017\001\036\n\017\016 \022\017\001\036\004\027\017\022\026\ \) [51].)Tj -0.104 Tw T* (\224\006\017\027\021\017\020\030\026\235\017\016 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\212\230\025 \023\024\r\024\035\016\036\021 \r\t\016\r\017\021\034 \220\ \022\f\021\030\026\r\026\026)Tj 0 Tw (-)Tj -0.002 Tw T* (\006\017\033 \r)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\f\r\036\021 \021\024\035\f\021\024\005 \022\017\001\022\017\ \220\030\017\021\030\024\006\017\021\024\r, \n\036\004\036\027\027\t\b \ )Tj 0.139 Tw T* (\021\036\b\027\036\006\017\036\n, \r)Tj /Span<>> BDC ( )Tj EMC (\021\024\n \004\017\f\035\036, \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\022\030\024\r\024\021\036\004\036\027\017\016\b \f)Tj /Span<>> BDC ( )Tj EMC (\024\004\036\027\034 )Tj 0.13 Tw T* (\027\017\022\024\005 \f\022\024\030\024\f\021\034\033 \(0,04)Tj /Span<>> BDC ( )Tj EMC (\n\035/\n\017\027.\) [21]. \215\024\n\036\004\036\027\027\t\036 )Tj 0.08 Tw T* (\017\024\021\024\023\024\n \220\030\017\021\030\024\006\017\021\t \006\017\ \030\022\031\035\017\030\031\033\021 \r)Tj /Span<>> BDC ( )Tj EMC (\021\036\004\036\027\017\036 48 \004\026)Tj 0 Tw (-)Tj -0.027 Tw T* (\f\024\r, \004\021\024 \023\024\r\024\035\016\036\021 \023\030\024\r\036\ \f\021\017 \023\024\r\021\024\030\027\024\036 \f\022\026\027\017\030\024\ \r\026\027\017\036 )Tj 0.014 Tw T* (\031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\026 \f)Tj /Span<>> BDC ( )Tj EMC (\030\026\027\027\017\n \030\036\006\017\007\017\r\024\n \022\030\024\r\024\ \021\036\004\036\027\017\016 \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\036)Tj 0 Tw (-)Tj 0.149 Tw T* (\007\t\007\031\013\017\n \024\021\030\017\006\026\021\036\035\034\027\t\n\ \030\036\031\035\034\021\026\021\024\n \017\f\f\035\036\007\024\r\026\027\ \017\016 )Tj 0.239 Tw T* ([54]. \224\031\013\036\f\021\r\036\027\027\t\n \024\020\030\026\027\017\004\ \036\027\017\036\n \022)Tj /Span<>> BDC ( )Tj EMC (\022\035\017\027\017\004\036\f\022\024\n\031 )Tj 0.138 Tw T* (\017\f\023\024\035\034\024\r\026\027\017\033 \007\026\027\027\024\005 \n\ \036\021\024\007\017\022\017 \016\r\035\016\036\021\f\016 \036\036 \027\036\ \007\024)Tj 0 Tw (-)Tj 0.096 Tw T* (\f\021\031\023\027\024\f\021\034 \r)Tj /Span<>> BDC ( )Tj EMC (\022\026\004\036\f\021\r\036 \220\022\f\021\030\036\027\027\024\005 \023\ \030\024\006\036\007\031\030\t \r)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\034)Tj 0 Tw (-)Tj 0.109 Tw T* (\001\017\027\f\021\r\036 \035\036\004\036\002\027\t\b \031\004\030\036\032\ \007\036\027\017\005. \025\030\024\n\036 \021\024\020\024, \030\036\031\ \035\034)Tj 0 Tw (-)Tj 0.158 Tw T* (\021\026\021\t \f\022\026\027\017\030\024\r\026\027\017\016 \027\036 \023\ \024\r\024\035\016\033\021 \021\024\004\027\024 \024\023\030\036\007\036\ \035\017\021\034 )Tj 0.107 Tw T* [(\035\024\022\026\035\017\026\006\017\033 \017\f\021\024\004\027\017\022\ \026 )0.5(\022\030\024\r\024\021\036\004\036\027\017\016 \002\036 \023\030\017\n\036\ \027\036)]TJ 0 Tw (-)Tj 0.146 Tw T* (\027\017\016 \007\030\031\020\017\b \n\036\021\024\007\024\r \r\017\031\ \026\035\017\026\006\017\017. \200)Tj /Span<>> BDC ( )Tj EMC (\006\036\035\024\n \220\235\235\036\022)Tj 0 Tw (-)Tj 0.559 Tw T* (\021\017\r\027\024\f\021\034 \023\030\017\n\036\027\036\027\017\016 \f\022\ \026\027\017\030\024\r\026\027\017\016 \220\030\017\021\030\024\006\017\021\ \024\r )Tj -0.037 Tw T* (\023\030\017)Tj /Span<>> BDC ( )Tj EMC (\035\036\004\036\027\017\017 \020\026\f\021\030\024\017\027\021\036\f\021\ \017\027\026\035\034\027\t\b \022\030\024\r\024\021\036\004\036\027\017\005\ \f\024)Tj 0 Tw (-)Tj 0.096 Tw T* (\f\021\026\r\035\016\036\021 \n\036\027\036\036 20% [21]. \215\024\035\024\ \032\017\021\036\035\034\027\t\005 \030\036\031\035\034\021\026\021 )Tj 0.231 Tw T* (\f\022\026\027\017\030\024\r\026\027\017\016 \220\030\017\021\030\024\006\ \017\021\024\r \r)Tj /Span<>> BDC ( )Tj EMC (\021\036\004\036\027\017\036 30\22660)Tj /Span<>> BDC ( )Tj EMC (\n\017\027\031\021 )Tj 0.195 Tw T* (\023\024\f\035\036 \r\r\036\007\036\027\017\016 \030\026\007\017\024\027\ \031\022\035\017\007\026 \n\024\032\027\024 \017\f\023\024\035\034\024\r\ \026\021\034 )Tj 0.102 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\022\026\004\036\f\021\r\036 \f\022\030\017\027\017\027\020\024\r\024\020\ \024 \021\036\f\021\026 \023\036\030\036\007 \r\t\023\024\035\027\036\027\ \017\036\n )Tj 0 Tw T* (\023\024\f\035\036\007\031\033\013\036\005 \f\036\035\036\022\021\017\r\027\ \024\005 \026\027\020\017\024\020\030\026\235\017\017 [54].)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 303.3769 262.0658 Tm [(\020)21(\026\027\r\241\224\034\022\031\034)]TJ 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0 Tc 0.243 Tw 10 0 0 10 303.3071 237.7098 Tm (\200\024\n\024\032\027\024\f\021\017 \220\235\235\036\022\021\017\r\027\ \024\005 \007\017\026\020\027\024\f\021\017\022\017 \212\230\025 \n\024\020\ \031\021 )Tj 0.194 Tw T* (\002\t\021\034 \031\f\023\036\001\027\024 \030\036\026\035\017\024\r\026\ \027\t \023\031\021\036\n \n\031\035\034\021\017\007\017\f\006\017\023\035\ \017)Tj 0 Tw (-)Tj 0.001 Tw T* (\027\026\030\027\024\020\024 \r\026\017\n\024\007\036\005\f\021\r\017\016\ \030\026\035\017\004\027\t\b \f\023\036\006\017\026\035\017\f\021\024\r\ )Tj /Span<>> BDC ( )Tj EMC (\227 )Tj 1.23 Tw T* (\b\017\030\031\030\020\024\r, \022\024\035\024\023\030\024\022\021\024\035\ \024\020\024\r, \020\026\f\021\030\024\220\027\021\036\030\024\035\024\020\ \024\r, )Tj 0.826 Tw T* (\220\027\007\024\f\022\024\023\017\f\021\024\r, \030\036\027\021\020\036\ \027\024\035\024\020\024\r, \017\027\021\036\030\r\036\027\006\017\024\027\ \027\t\b )Tj 0.322 Tw T* (\030\026\007\017\024\035\024\020\024\r. \025\024\035\024\027\024\f\022\024\ \023\017\016 \030\036\022\024\n\036\027\007\031\036\021\f\016 \r)Tj /Span<>> BDC ( )Tj EMC (\022\026\004\036)Tj 0 Tw (-)Tj 0.187 Tw T* (\f\021\r\036 \024\f\027\024\r\027\024\020\024 \027\026\004\026\035\034\027\ \024\020\024 \007\017\026\020\027\024\f\021\017\004\036\f\022\024\020\024\ \n\036\021\024)Tj 0 Tw (-)Tj 0.131 Tw T* (\007\026 \024\002\f\035\036\007\024\r\026\027\017\016 \002\024\035\034\027\ \t\b \f)Tj /Span<>> BDC ( )Tj EMC (\023\024\007\024\030\036\027\017\036\n \027\026)Tj /Span<>> BDC ( )Tj EMC (\024\f\021\030\024\036 )Tj 0.463 Tw T* (\021\024\035\f\021\024\022\017\001\036\004\027\024\036 \022\030\024\r\024\ \021\036\004\036\027\017\036. \025\024\n\023\034\033\021\036\030\027\026\ \016 \021\024)Tj 0 Tw (-)Tj 0.085 Tw T* (\n\024\020\030\026\235\017\016 \f)Tj /Span<>> BDC ( )Tj EMC (\022\024\027\021\030\026\f\021\027\t\n \031\f\017\035\036\027\017\036\n \ \n\024\032\036\021 \002\t\021\034 \r\t)Tj 0 Tw (-)Tj 0.219 Tw T* (\002\030\026\027\026 \027\026\004\026\035\034\027\t\n \007\017\026\020\027\ \024\f\021\017\004\036\f\022\017\n \n\036\021\024\007\024\n \024\002\f\035\ \036)Tj 0 Tw (-)Tj 0.227 Tw T* (\007\024\r\026\027\017\016 \r)Tj /Span<>> BDC ( )Tj EMC (\f\035\031\004\026\016\b, \022\024\020\007\026 \220\022\f\021\030\036\027\ \027\026\016 \022\026\004\036\f\021\r\036\027\027\026\016 )Tj 0.154 Tw T* (\022\024\035\024\027\024\f\022\024\023\017\016 \027\036 \n\024\032\036\021\ \002\t\021\034 \r\t\023\024\035\027\036\027\026 \017-\026 \r\024)Tj 0 Tw (-)Tj 0.448 Tw T* [(\n\024\032\027\024\f\021\036\005 \n\036\007\017\006\017\027\f\022\024\020\ \024 )0.5(\031\004\030\036\032\007\036\027\017\016 \017\035\017, \022\024\020\007\026\ )]TJ 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0 Tw 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\206)10(\002\036\033 \035\030\032\003\033)30(\n)42(\032)-21(\230\033\241)]TJ 57.136 0 Td (REVIEW)Tj -57.136 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 2)69(4, \023\0224, 202)23(5)]TJ 43.013 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 2)69(4, \023\0224, 202)23(5)]TJ /T1_3 1 Tf 25 0 0 25 20.8528 56.0378 Tm (214)Tj ET endstream endobj 114 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\240\021\001\202\215\025\b)-9.9(\026\021\017\001 \211\021\r\016\201\026\021\017\200\t\004\201\215\220 \026\ )11.1(\025\t\b)-10(\026)11(\025\017\021\020\016\f\215\220 )]TJ 0 -1 TD [(\017\201\025\r\025\026)11(\016\f\016\215\021\207 \(\025\235\213\025\201 \t\021\026)11(\016\201\001\026)-19.9(\200\201\220\))]TJ 39.93 1 Td [(Diagnostics of\022div)12.1(er)-20(ticular colonic bleeding \(r)31(e)11(vie)11(w\))]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0.344 Tw 10 0 0 10 42.5197 724.8299 Tm (\210\007\027\017\n \017)Tj /Span<>> BDC ( )Tj EMC (\r\024\n\024\032\027\t\b \r\026\030\017\026\027\021\024\r \220\027\007\024\ \f\022\024\023\017\004\036\f\022\024\005 )Tj 0.102 Tw 0 -1.218 TD (\007\017\026\020\027\024\f\021\017\022\017 \212\230\025 \023\030\036\007\ \035\026\020\026\036\021\f\016 \017\f\023\024\035\034\024\r\026\027\017\ \036 \f\030\024\004)Tj 0 Tw (-)Tj 0.063 Tw T* (\027\024\005 \022\026\023\f\031\035\034\027\024\005 \220\027\007\024\f\022\ \024\023\017\017 \021\024\035\f\021\024\005 \022\017\001\022\017, \022\024\ \021\024\030\026\016, )Tj 0.454 Tw T* [(\f\024\020\035\026\f\027\024 )0.5(\023\036\030\r\024\027\026\004\026\035\034\027\t\n )0.6(\030\036\031\035\034\021\026\021\026\n, )0.6(\023\024\r\024\035\016\036\021 )]TJ 0.08 Tw T* (\002\024\035\036\036 \004\036\n \031)Tj /Span<>> BDC ( )Tj EMC (80% \023\026\006\017\036\027\021\024\r \031\f\021\026\027\024\r\017\021\034\ \b\026\030\026\022\021\036\030 \026)Tj 0 Tw (-)Tj T* (\002\024\035\036\r\026\027\017\016 \017)Tj /Span<>> BDC ( )Tj EMC (\035\024\022\026\035\017\024\r\026\021\034 \n\036\f\021\024 \022\030\024\ \r\024\021\036\004\036\027\017\016 [16].)Tj -0.004 Tc 0.065 Tw 0 -1.218 TD (\200 \022\035\017\027\017\004\036\f\022\024\005 \023\030\026\022\021\017\ \022\036 \007\035\016 \b\026\030\026\022\021\036\030\017\f\021\017\022\017\ \212\230\025 \017\f)Tj 0 Tc 0 Tw (-)Tj -0.004 Tc 0.497 Tw 0 -1.218 TD [(\023\024\035\034\031\033\021\f\016 )0.5(\220\027\007\024\f\022\024\023\017\004\036\f\022\017\036 )0.5(\023\030\017\027\026\022\017 )0.5(\027\036\007\026\r\027\036\020\024)-4( )]TJ -0.017 Tw T* [(\022\030\024\r\024\021\036\004\036\027\017\016 \(st)-32(igma)15(t)15(a of)]TJ /Span<>> BDC ( )Tj EMC [(r)-23.9(ecent hemor)-24(r)-24(ha)-17(ge)]TJ /Span<>> BDC ( )Tj EMC [(\227 SRH\),)-4( )]TJ 0.122 Tw T* (\f\b\024\032\017\036 \f)Tj /Span<>> BDC ( )Tj EMC [(\030\026\f\023\030\024\f\021\030\026\027\036\027\027\024\005 \022\035\026\ \f\f\017\235\017\022\026\006\017\036\005 F)10(or)-24(r)-24(est)-4( )]TJ 0.038 Tw T* (\007\035\016 \016\r\036\027\027\t\b \020\026\f\021\030\024\007\031\024\007\ \036\027\026\035\034\027\t\b \022\030\024\r\024\021\036\004\036\027\017\005\ : \026\022)Tj 0 Tc 0 Tw (-)Tj -0.004 Tc -0.051 Tw T* (\021\017\r\027\024\036 \022\030\024\r\024\021\036\004\036\027\017\036)Tj /Span<>> BDC ( )Tj EMC [(\227 a)-17(c)-16(t)-31.9(i)-16(ve bleeding \(A)44(B\), )0.5(\r\017\007\017\n\t\036)-4( )]TJ 0.032 Tw 0 -1.218 TD (\f\024\f\031\007\t \002\036 \022\030\024\r\024\021\036\004\036\027\017\016\ )Tj /Span<>> BDC ( )Tj EMC [(\227 non-bleeding v)-16(isible ves)]TJ 0 Tc 0 Tw (-)Tj -0.004 Tc -0.008 Tw 0 -1.218 TD [(sels )0.6(\(NB)10(VV\) )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 5.504 0 Td [(\235\017\022\f\017\030\024\r\026\027\027\t\005 )0.5(\f\020\031\f\021\024\022)]TJ /Span<>> BDC ( )Tj EMC 10.086 0 Td [(\227 )0.5(adher)-23.9(ent )0.5(cl)30(o)17(t)-4( )]TJ 0.151 Tw -15.59 -1.218 Td [(\(A)16(C\), \023\024\f\035\036 \031\007\026\035\036\027\017\016 \022\024\021\024\ \030\024\020\024 \r\t\016\r\035\016\036\021\f\016 \026\022\021\017\r\027\ \024\036)-4( )]TJ -0.021 Tw 0 -1.218 TD (\022\030\024\r\024\021\036\004\036\027\017\036 \017\035\017 \r\017\007\017\ \n\t\005 \f\024\f\031\007 [12,40]. \200)Tj /Span<>> BDC ( )Tj EMC [(\f\021\030\031\022\021\031\030\036)-4( )]TJ 0.042 Tw T* [(\212\230\025 )0.5(\024\021\n\036\004\026\036\021\f\016 )0.5(\023\030\017\n\036\030\027\024 )0.5(\030\026\r\027\024\036 )0.6(\030\026\f\023\030\036\007\036\035\036\027\017\036 )0.5(\r\t)]TJ 0 Tc 0 Tw (-)Tj -0.004 Tc 0.111 Tw T* [(\016\r\035\016\036\n\t\b \220\027\007\024\f\022\024\023\017\004\036\f\022\ \017\b \f\021\017\020\n\026\021\024\r \022\030\024\r\024\021\036\004\036\ \027\017\016:)-4( )]TJ 0.038 Tw T* (\026\022\021\017\r\027\024\036 \022\030\024\r\024\021\036\004\036\027\017\ \036)Tj /Span<>> BDC ( )Tj EMC [(\227 34,9%; \r\017\007\017\n\t\005 \f\024\f\031\007 \002\036)-4( )]TJ 0.184 Tw T* (\022\030\024\r\024\021\036\004\036\027\017\016)Tj /Span<>> BDC ( )Tj EMC (\227 32,5%; \235\017\022\f\017\030\024\r\026\027\027\t\005 \f\020\031\f\021\ \024\022)Tj /Span<>> BDC ( )Tj EMC [(\227)-4( )]TJ 0.222 Tw T* (32,5% [41]. \025\024\035\024\027\024\f\022\024\023\017\004\036\f\022\026\ \016 \r\017\031\026\035\017\026\006\017\016 \f\021\017\020)Tj 0 Tc 0 Tw (-)Tj -0.004 Tc 0.139 Tw T* (\n\026\021\024\r \022\030\024\r\024\021\036\004\036\027\017\016 \023\024\ \r\024\035\016\036\021 \r\t\007\036\035\017\021\034 \007\r\026 \022\035\ \017\027\017)Tj 0 Tc 0 Tw (-)Tj -0.004 Tc 0.304 Tw T* [(\004\036\f\022\017\b \r\026\030\017\026\027\021\026 \007\017\r\036\030\021\ \017\022\031\035\016\030\027\t\b \021\024\035\f\021\024\022\017\001\036\004\ \027\t\b)-3.9( )]TJ 0.369 Tw T* (\022\030\024\r\024\021\036\004\036\027\017\005)Tj /Span<>> BDC ( )Tj EMC (\227 \016\r\027\024\036 \017)Tj /Span<>> BDC ( )Tj EMC [(\023\030\036\007\023\024\035\026\020\026\036\n\024\036. \233\r\027\024\036\ )-4( )]TJ 0.135 Tw T* [(\(\024\023\030\036\007\036\035\036\027\027\024\036\) )0.5(\007\017\r\036\030\021\017\022\031\035\016\030\027\024\036 )0.5(\022\030\024\r\024\021\036\004\036\027\017\036 )0.5(\(de)]TJ 0 Tc 0 Tw (-)Tj -0.004 Tc 0.237 Tw T* [(\251ni)-23.9(t)-32(i)-16(ve di)-16(ver)-21.9(t)-32(icul)-16(ar bleeding\) \023\024\007\021\r\036\030\032\007\026\036\021\f\016 \r\017\ \031)]TJ 0 Tc 0 Tw (-)Tj -0.004 Tc 0.265 Tw T* [(\026\035\017\026\006\017\036\005 )0.5(\007\017\r\036\030\021\017\022\031\035\026 )0.5(\021\024\035\f\021\024\005 )0.5(\022\017\001\022\017 )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC 18.145 0 Td [(\027\026\035\017\004\017\036\n)-4( )]TJ -0.026 Tw -18.145 -1.218 Td (\024\007\027\024\020\024 \017)Tj /Span<>> BDC ( )Tj EMC (\r\t\001\036\023\036\030\036\004\017\f\035\036\027\027\t\b \220\027\007\024\ \f\022\024\023\017\004\036\f\022\017\b \023\030\017)Tj 0 Tc 0 Tw (-)Tj -0.004 Tc -0.051 Tw T* (\027\026\022\024\r \022\030\024\r\024\021\036\004\036\027\017\016. \215\ \030\036\007\023\024\035\026\020\026\036\n\024\036 \007\017\r\036\030\021\ \017\022\031\035\016\030)Tj 0 Tc 0 Tw (-)Tj -0.004 Tc 0.062 Tw T* [(\027\024\036 \022\030\024\r\024\021\036\004\036\027\017\036 \(p)25(r)-24(esum)10(pt)-32(i)-16(ve di)-16(ver)-22(t)-32(icul)-16(ar bleeding\))-4( )]TJ 0.136 Tw T* [(\027\036 \023\024\007\021\r\036\030\032\007\026\036\021\f\016 \r\t\016\r\ \035\036\027\027\t\n\017 \220\027\007\024\f\022\024\023\017\004\036\f\022\ \017\n\017)-4( )]TJ 0.184 Tw T* [(\023\030\017\027\026\022\026\n\017 )0.5(\022\030\024\r\024\021\036\004\036\027\017\016 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 12.32 0 Td [(\024\f\027\024\r\t\r\026\036\021\f\016 )0.5(\027\026)]TJ /Span<>> BDC ( )Tj EMC 7.474 0 Td (\024\002\027\026)Tj 0 Tc 0 Tw (-)Tj -0.004 Tc 0.175 Tw -19.794 -1.218 Td (\030\031\032\036\027\017\017 \f\r\036\032\036\005 \022\030\024\r\017, \035\ \024\022\026\035\017\024\r\026\027\027\024\005 \r)Tj /Span<>> BDC ( )Tj EMC (\007\017\r\036\030\021\017)Tj 0 Tc 0 Tw (-)Tj -0.004 Tc 0.261 Tw T* [(\022\031\035\026\b \021\024\035\f\021\024\005 \022\017\001\022\017 \017\035\ \017 \r\t\016\r\035\036\027\017\017 \016\030\022\024-\022\030\026\f\027\024\ \005)-4( )]TJ 0.115 Tw T* (\022\030\024\r\017 \r)Tj /Span<>> BDC ( )Tj EMC (\023\030\016\n\024\005 \022\017\001\022\036 \023\030\017)Tj /Span<>> BDC ( )Tj EMC [(\027\026\035\017\004\017\017 \023\024\021\036\027\006\017\026\035\034\027\ \024\020\024)-4( )]TJ 0.207 Tw T* (\017\f\021\024\004\027\017\022\026 \022\030\024\r\024\021\036\004\036\027\ \017\016 \r)Tj /Span<>> BDC ( )Tj EMC (\007\017\r\036\030\021\017\022\031\035\036 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\r\t\023\024\035)Tj 0 Tc 0 Tw (-)Tj -0.004 Tc 0.346 Tw T* (\027\036\027\027\024\005 \021\024\021\026\035\034\027\024\005 \022\024\035\ \024\027\024\f\022\024\023\017\017, \007\024\023\024\035\027\036\027\027\ \024\005 \024\021)Tj 0 Tc 0 Tw (-)Tj -0.004 Tc 0.055 Tw T* (\030\017\006\026\021\036\035\034\027\024\005 \220\027\007\024\f\022\024\023\ \017\036\005 \r\036\030\b\027\017\b \024\021\007\036\035\024\r \032\036\035\ \031\007\024\004)Tj 0 Tc 0 Tw (-)Tj -0.004 Tc 0.071 Tw T* [(\027\024-\022\017\001\036\004\027\024\020\024 \021\030\026\022\021\026, \ \017\035\017 \024\021\030\017\006\026\021\036\035\034\027\024\005 \022\026\ \023\f\031\035\034\027\024\005)-4( )]TJ 0.624 Tw T* [(\220\027\007\024\f\022\024\023\017\036\005, \017\035\017 \024\021\030\017\ \006\026\021\036\035\034\027\t\n \017\f\f\035\036\007\024\r\026\027\017\036\ \n)-4( )]TJ 0.089 Tw T* (\032\036\035\031\007\022\026 \f)Tj /Span<>> BDC ( )Tj EMC [(\023\024\n\024\013\034\033 \027\026\024\020\026\f\021\030\026\035\034\027\ \024\020\024 \024\027\007\026 [12,40].)-4( )]TJ 0.42 Tw T* (\215\030\036\007\035\026\020\026\036\021\f\016 \021\026\022\032\036 \r\t\ \007\036\035\016\021\034 \f\024\023\031\021\f\021\r\031\033\013\031\033 \ \007\017)Tj 0 Tc 0 Tw (-)Tj -0.004 Tc 0.097 Tw T* (\r\036\030\021\017\022\031\035\016\030\027\031\033 \002\024\035\036\027\ \034 \021\024\035\f\021\024\005 \022\017\001\022\017, \023\030\017)Tj /Span<>> BDC ( )Tj EMC [(\027\026\035\017\004\017\017)-4( )]TJ 0.007 Tw T* [(\022\024\021\024\030\024\005 \024\023\030\036\007\036\035\016\036\021\f\016\ \007\030\031\020\024\005 \017\f\021\024\004\027\017\022 \022\030\024\r\024\ \021\036\004\036\027\017\016)-4( )]TJ 0 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\021\024\035\f\021\024\005 \017\035\017 \021\024\027\022\024\005 \022\017\ \001\022\036 [16].)Tj /T1_2 1 Tf 0 Tc 0 -2.436 TD (\035\210\201\r\013\r \214\r\003\002\240\013 \t\213\210\004\f\t\213\004\ \204\t\t )Tj /Span<>> BDC ( )Tj EMC (\240\t\004\n\b\002\217\003\t\220\r \031\020\021)Tj /T1_1 1 Tf -0.037 Tw 0 -1.218 TD (\200 \027\026\f\021\024\016\013\036\036 \r\030\036\n\016 \022\024\n\023\034\ \033\021\036\030\027\026\016 \021\024\n\024\020\030\026\235\017\016 \f)Tj /Span<>> BDC ( )Tj EMC (\022\024\027\021)Tj /Span<>> BDC (-)Tj EMC 0.33 Tw T* (\030\026\f\021\027\t\n \031\f\017\035\036\027\017\036\n \030\026\f\f\n\026\ \021\030\017\r\026\036\021\f\016 \r\024\f\021\030\036\002\024\r\026\027)Tj 0 Tw (-)Tj 0.433 Tw T* (\027\t\n \n\036\021\024\007\024\n \007\017\026\020\027\024\f\021\017\022\ \017 \024\f\021\030\t\b \020\026\f\021\030\024\017\027\021\036\f\021\017\ )Tj 0 Tw (-)Tj 0.402 Tw T* (\027\026\035\034\027\t\b \022\030\024\r\024\021\036\004\036\027\017\005.\ \212\017\026\020\027\024\f\021\017\004\036\f\022\026\016 \021\024\004\027\ \024\f\021\034 )Tj 0.12 Tw T* (\022\024\n\023\034\033\021\036\030\027\024\005 \026\027\020\017\024\020\030\ \026\235\017\017 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\024\f\021\030\t\b \032\036\035\031\007\024\004\027\024-)Tj 0.24 Tw T* [(\022\017\001\036\004\027\t\b )0.5(\022\030\024\r\024\021\036\004\036\027\017\016\b \f\024\f\021\026\r\035\016\ \036\021 )0.5(85,2%, \f\023\036\006\017)]TJ 0 Tw (-)Tj T* (\235\017\004\027\024\f\021\034)Tj /Span<>> BDC ( )Tj EMC (\227 92,1% [42].)Tj 0.432 Tw 23.244 64.543 Td (\215\030\017 \024\002\f\035\036\007\024\r\026\027\017\017 \002\024\035\034\ \027\t\b \031\f\023\036\001\027\024\036 \r\t\016\r\035\036\027\017\036 )Tj 0.239 Tw T* [(\022\030\024\r\024\021\024\004\026\013\036\020\024 \007\017\r\036\030\021\ \017\022\031\035\026 )0.5(\f\r\016\026\027\024 \f\024 \f\035\036\007\031\033\013\017)]TJ 0 Tw (-)Tj 0.065 Tw T* (\n\017 \235\026\022\021\024\030\026\n\017: \r\024\030\026\f\021 \023\026\ \006\017\036\027\021\026 \f\021\026\030\001\036 80)Tj /Span<>> BDC ( )Tj EMC (\035\036\021, \220\022\f)Tj 0 Tw (-)Tj 0.094 Tw T* (\021\030\026\r\026\026\006\017\016 \017\035\017 \f\022\024\023\035\036\027\ \017\036 \032\017\007\022\024\f\021\017 \r)Tj /Span<>> BDC ( )Tj EMC (\021\024\035\f\021\024\005 \022\017\001)Tj 0 Tw (-)Tj 0.189 Tw T* (\022\036 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\022\024\n\023\034\033\021\036\030\027\024\005 \021\024\n\024\020\030\026\ \235\017\017 \017)Tj /Span<>> BDC ( )Tj EMC (\022\024\035\024\027\024\f\022\024\023\017\016, )Tj 0.139 Tw T* (\023\030\024\r\036\007\036\027\027\026\016 \r)Tj /Span<>> BDC ( )Tj EMC (\021\036\004\036\027\017\036 \023\036\030\r\t\b 24)Tj /Span<>> BDC ( )Tj EMC (\004\026\f\024\r \023\024\f\035\036 \020\024\f)Tj 0 Tw (-)Tj 0.088 Tw 0 -1.218 TD (\023\017\021\026\035\017\026\006\017\017. \202\r\021\024\030\t \f\004\017\ \021\026\033\021, \004\021\024 \024\002\t\004\027\026\016 \022\024\n\023\ \034\033)Tj 0 Tw (-)Tj 0.286 Tw 0 -1.218 TD [(\021\036\030\027\026\016 \021\024\n\024\020\030\026\235\017\016, \023\024\ \r\024\035\016\033\013\026\016 )0.5(\023\024\007\021\r\036\030\007\017\021\034 \027\026)]TJ 0 Tw (-)Tj 0.058 Tw T* (\035\017\004\017\036 \f\022\024\023)Tj /Span<>> BDC ( )Tj EMC 4.638 0 Td (\035\036\027\017\016 \032\017\007\022\024\f\021\017 \r)Tj /Span<>> BDC ( )Tj EMC (\021\024\035\f\021\024\005 \022\017\001\022\036, \026)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\032\036 )Tj 0.582 Tw -4.638 -1.218 Td (\022\024\n\023\034\033\021\036\030\027\026\016 \021\024\n\024\020\030\026\ \235\017\016 \f)Tj /Span<>> BDC ( )Tj EMC (\022\024\027\021\030\026\f\021\017\030\024\r\026\027\017\036\n, )Tj -0.041 Tw T* (\f\023\024\f\024\002\027\026\016 \r\t\016\r\017\021\034 \023\030\017\027\ \026\022\017 \220\022\f\021\030\026\r\026\026\006\017\017, \023\024\035\ \036\027\t )Tj 0.054 Tw T* (\007\035\016 \023\030\017\027\016\021\017\016 \030\036\001\036\027\017\016\ \024)Tj /Span<>> BDC ( )Tj EMC (\027\036\024\002\b\024\007\017\n\024\f\021\017 \023\030\024\r\036\007\036\ \027\017\016 )Tj 0.226 Tw 0 -1.218 TD (\f\030\024\004\027\024\005 \220\027\007\024\f\022\024\023\017\017 \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\022\030\024\r\024\021\036\004\036\027\017\036\n )Tj 0.448 Tw 0 -1.218 TD (\017)Tj /Span<>> BDC ( )Tj EMC (\027\017\032\027\017\b \024\021\007\036\035\024\r \032\036\035\031\007\024\ \004\027\024-\022\017\001\036\004\027\024\020\024 \021\030\026\022\021\026\ )Tj 0.277 Tw 0 -1.218 TD (\f)Tj /Span<>> BDC ( )Tj EMC (\023\024\007\024\030\036\027\017\036\n \027\026)Tj /Span<>> BDC ( )Tj EMC (\007\017\r\036\030\021\017\022\031\035\016\030\027\024\036 \022\030\024\r\ \024\021\036\004\036\027\017\036. )Tj 0.004 Tw T* [(\025\030\024\n\036 \021\024\020\024, )0.5(\030\036\031\035\034\021\026\021\t )0.5(\025\230 \f)]TJ /Span<>> BDC ( )Tj EMC [(\022\024\027\021\030\026\f\021\017\030\024\r\026\027\017\036\n )0.5(\r\026\032)]TJ 0 Tw (-)Tj 0.041 Tw T* (\027\t \007\035\016 \023\035\026\027\017\030\024\r\026\027\017\016 \007\026\ \035\034\027\036\005\001\036\020\024 \035\036\004\036\027\017\016 \r)Tj /Span<>> BDC ( )Tj EMC (\f\035\031\004\026\036 )Tj 0.165 Tw T* [(\027\036\220\235\235\036\022\021\017\r\027\024\f\021\017 )0.6(\220\027\007\024\f\022\024\023\017\004\036\f\022\024\020\024 )0.6(\020\036\n\024\f\021\026\026, )0.5(\022\024\020)]TJ 0 Tw (-)Tj 0.226 Tw T* (\007\026 \024\002\f\031\032\007\026\036\021\f\016 \r\024\n\024\032\027\024\ \036 \023\030\017\n\036\027\036\027\017\036 \021\030\026\027\f\022\026\021\ \036)Tj 0 Tw (-)Tj 0.141 Tw T* [(\021\036\030\027\024\005 \026\030\021\036\030\017\026\035\034\027\024\005\ )0.5(\220\n\002\024\035\017\026\006\017\017 \017\035\017 \r\t\023\024\035\027\ \036\027\017\036 )]TJ -0.034 Tw T* (\b\017\030\031\030\020\017\004\036\f\022\024\020\024 \r\n\036\001\026\021\ \036\035\034\f\021\r\026 [43]. \200\n\036\f\021\036 \f)Tj /Span<>> BDC ( )Tj EMC (\021\036\n, \017\f)Tj 0 Tw (-)Tj 0.061 Tw T* (\023\024\035\034\024\r\026\027\017\036 \025\230 \f)Tj /Span<>> BDC ( )Tj EMC (\022\024\027\021\030\026\f\021\027\t\n \031\f\017\035\036\027\017\036\n \ \023\036\030\036\007 \r\t)Tj 0 Tw (-)Tj 0.036 Tw T* (\023\024\035\027\036\027\017\036\n \022\024\035\024\027\024\f\022\024\023\ \017\017 \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\024\f\021\030\t\n\017 \007\017)Tj 0 Tw (-)Tj 0.224 Tw T* (\r\036\030\021\017\022\031\035\016\030\027\t\n\017 \021\024\035\f\021\024\ \022\017\001\036\004\027\t\n\017 \022\030\024\r\024\021\036\004\036\027\017\ \016\n\017 )Tj 0.185 Tw T* (\023\024\022\026\026\035\024 \027\017\022\031\033 \004\026\f\021\024\021\ \031 \r\t\016\r\035\036\027\017\016 \220\022\f\021\030\026\r\026\026\006\ \017\017 )Tj 0.025 Tw T* (\(15\22636%\) \017)Tj /Span<>> BDC ( )Tj EMC (\027\017\022\031\033 \004\031\r\f\021\r\017\021\036\035\034\027\024\f\021\ \034 \(20\22652%\) [44\226)Tj -0.052 Tw T* (46]. \225\021\024 \f\r\016\026\027\024 \f)Tj /Span<>> BDC ( )Tj EMC (\021\036\n, \004\021\024 \220\022\f\021\030\026\r\026\026\006\017\016, \ \r\t\016\r\035\016\036\n\026\016 )Tj -0.01 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\023\024\n\024\013\034\033 \025\230 \f)Tj /Span<>> BDC ( )Tj EMC (\022\024\027\021\030\026\f\021\017\030\024\r\026\027\017\036\n, \031\022\ \026\t\r\026\036\021 \027\026)Tj /Span<>> BDC ( )Tj EMC (\026\022)Tj 0 Tw (-)Tj 0.026 Tw T* [(\021\017\r\027\024\036 )0.5(\022\030\024\r\024\021\036\004\036\027\017\036, )0.6(\023\024\f\022\024\035\034\022\031 )0.5(\023\030\017)]TJ /Span<>> BDC ( )Tj EMC 15.527 0 Td [(\007\026\027\027\024\n )0.5(\023\030\017\027\026)]TJ 0 Tw (-)Tj -0.042 Tw -15.527 -1.218 Td [(\022\036 )0.5(\f\022\024\030\024\f\021\034 )0.6(\022\030\024\r\024\021\036\004\036\027\017\016 )0.5(\023\030\036\r\t\001\026\036\021 )0.6(0,3\2260,5)]TJ /Span<>> BDC ( )Tj EMC 18.725 0 Td (\n\035/\n\017\027. )Tj 0.049 Tw -18.725 -1.218 Td (\215\024\220\021\024\n\031 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\r\t\023\024\035\027\036\027\017\017 \022\024\035\024\027\024\f\022\024\023\ \017\017 \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r )Tj 0.13 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\031\f\021\026\027\024\r\035\036\027\027\024\005 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\025\230 \220\022\f\021\030\026\r\026\026\006\017\036\005 \022\030\024\r\ \024\021\024\004\026)Tj 0 Tw (-)Tj 0.222 Tw T* [(\013\017\036 \007\017\r\036\030\021\017\022\031\035\t \002\t\035\017 )0.5(\024\002\027\026\030\031\032\036\027\t )0.5(\031)]TJ /Span<>> BDC ( )Tj EMC (60\22668% \023\026)Tj 0 Tw (-)Tj 0.164 Tw T* (\006\017\036\027\021\024\r, \026)Tj /Span<>> BDC ( )Tj EMC [(\031 \023\026\006\017\036\027\021\024\r )0.5(\002\036 \220\022\f\021\030\026\r\026\026\006\017\017)]TJ /Span<>> BDC ( )Tj EMC (\227 \035\017\001\034 )Tj -0.019 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (20\22631% \f\035\031\004\026\036\r [47]. \232\026\f\021\024\021\026 \r\t\ \016\r\035\036\027\017\016 \f\021\017\020\n\026\021\024\r )Tj 0.146 Tw T* (\022\030\024\r\024\021\036\004\036\027\017\016 \023\030\017)Tj /Span<>> BDC ( )Tj EMC [(\r\t\023\024\035\027\036\027\017\017 )0.5(\022\024\035\024\027\024\f\022\024\023\017\017 \023\024\f\035\036 )]TJ 0.152 Tw T* [(\025\230 )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC 2.226 0 Td [(\022\024\027\021\030\026\f\021\017\030\024\r\026\027\017\036\n )0.6(\027\026\004\017\021\036\035\034\027\024 )0.6(\r\t\001\036 )0.5(\(35,7%\) )]TJ 0.214 Tw -2.226 -1.218 Td (\023\024)Tj /Span<>> BDC ( )Tj EMC (\f\030\026\r\027\036\027\017\033 \f)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\r\036\007\036\027\017\036\n \024\007\027\024\005 \022\024\035\ \024\027\024\f\022\024\023\017\017 )Tj 0 Tw T* (\(20,6%; )Tj /T1_3 1 Tf 3.594 0 Td (p)Tj /T1_1 1 Tf 0.236 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,01\), \004\021\024 \f\023\024\f\024\002\f\021\r\024\r\026\035\024 \031\ \r\036\035\017\004\036\027\017\033 )Tj 0.058 Tw -3.594 -1.218 Td (\004\017\f\035\026 \f\035\031\004\026\036\r \031\f\023\036\001\027\024\020\ \024 \220\027\007\024\f\022\024\023\017\004\036\f\022\024\020\024 \035\036\ \004\036\027\017\016 )Tj 0.167 Tw T* (\(34,9%)Tj /Span<>> BDC ( )Tj EMC (\227 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\r\t\023\024\035\027\036\027\017\017 \022\024\035\024\027\024\f\022\024\023\ \017\017 \023\024\f\035\036 \025\230 )Tj 0.119 Tw T* (\017\f\f\035\036\007\024\r\026\027\017\016 \023\024)Tj /Span<>> BDC ( )Tj EMC (\f\030\026\r\027\036\027\017\033 \f)Tj /Span<>> BDC ( )Tj EMC (13,4%)Tj /Span<>> BDC ( )Tj EMC (\227 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\r\t\023\024\035)Tj 0 Tw (-)Tj 0.106 Tw T* [(\027\036\027\017\017 )0.6(\021\024\035\034\022\024 )0.5(\022\024\035\024\027\024\f\022\024\023\017\017; )]TJ /T1_3 1 Tf 0 Tw 12.489 0 Td (p)Tj /T1_1 1 Tf 0.106 Tw /Span<>> BDC ( )Tj EMC 0.816 0 Td (<)Tj /Span<>> BDC ( )Tj EMC 0.838 0 Td [(0,01\) )0.5([48]. )0.5(\232\026\f\021\024\021\026 )]TJ 0.091 Tw -14.144 -1.218 Td (\r\t\016\r\035\036\027\017\016 \023\030\017\027\026\022\024\r \220\022\f\ \021\030\026\r\026\026\006\017\017 \031\r\036\035\017\004\017\r\026\036\ \021\f\016, )Tj 0.119 Tw T* (\036\f\035\017 \025\230-\026\027\020\017\024\020\030\026\235\017\016 \023\ \030\024\r\024\007\017\021\f\016 \r)Tj /Span<>> BDC ( )Tj EMC (\021\036\004\036\027\017\036 2 \004\026\f\024\r )Tj 0.027 Tw T* (\023\024\f\035\036 \023\024\f\035\036\007\027\036\020\024 \220\023\017\024\ \007\026 \020\036\n\026\021\024\b\036\017\017, \004\021\024 \023\024\r\ \024\035\016)Tj 0 Tw (-)Tj -0.034 Tw T* (\036\021 \023\030\036\007\023\024\035\024\032\017\021\034, \004\021\024 \ \025\230-\026\027\020\017\024\020\030\026\235\017\016 \n\024\032\036\021\ \002\t\021\034 \023\024)Tj 0 Tw (-)Tj -0.038 Tw T* (\022\026\026\027\026 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\024\f\021\030\024\n \007\017\r\036\030\021\017\022\031\035\016\030\027\024\ \n \021\024\035\f\021\024\022\017\001\036\004\027\024\n )Tj 0.008 Tw T* (\022\030\024\r\024\021\036\004\036\027\017\017 [12,22]. \200)Tj /Span<>> BDC ( )Tj EMC (\030\036\031\035\034\021\026\021\036 \n\027\024\020\024\006\036\027\021\ \030\024\r\024\020\024 )Tj 0.213 Tw T* (\030\026\027\007\024\n\017\017\030\024\r\026\027\027\027\024\020\024 \017\ \f\f\035\036\007\024\r\026\027\017\016 \002\t\035\024 \031\f\021\026\027\ \024\r)Tj 0 Tw (-)Tj 0.189 Tw T* [(\035\036\027\024, \004\021\024 \017\f\023\024\035\034\024\r\026\027\017\ \036 )0.5(\f\030\024\004\027\024\005 \025\230 )0.5(\023\036\030\036\007 \030\026\027\027\036\005 )]TJ 0.165 Tw T* (\022\024\035\024\027\024\f\022\024\023\017\036\005 \027\036 \031\035\031\ \004\001\017\035\024 \r\t\016\r\035\036\027\017\036 \220\027\007\024\f\022\ \024\023\017)Tj 0 Tw (-)Tj 0.243 Tw T* (\004\036\f\022\017\b \f\021\017\020\n\026\021\024\r \022\030\024\r\024\021\ \036\004\036\027\017\016 \017\035\017 \007\030\031\020\017\b \022\035\017\ \027\017)Tj 0 Tw (-)Tj 0.237 Tw T* [(\004\036\f\022\017\b )0.5(\017\f\b\024\007\024\r )0.6(\035\036\004\036\027\017\016 )0.6(\023\026\006\017\036\027\021\024\r )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC 16.651 0 Td (\023\024\007\024\030\036\027\017\036\n )Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 0 Tw 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\206)10(\002\036\033 \035\030\032\003\033)30(\n)42(\032)-21(\230\033\241)]TJ 57.136 0 Td (REVIEW)Tj /T1_4 1 Tf 25 0 0 25 505.4771 56.0378 Tm (213)Tj ET endstream endobj 112 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.112 Tw 10 0 0 10 70.8661 724.8299 Tm (\017\f\023\024\035\034\024\r\026\021\034 \007\024\023\023\035\036\030\024\ \r\f\022\017\005 \220\027\007\024\f\022\024\023\017\004\036\f\022\017\005\ \024\027\007 )Tj 0.097 Tw 0 -1.218 TD (\007\035\016 \024\006\036\027\022\017 \024\f\024\002\036\027\027\024\f\021\ \036\005 \022\030\024\r\024\f\027\026\002\032\036\027\017\016 \022\030\024\ \r\024\021\024)Tj 0 Tw (-)Tj 0.271 Tw T* (\004\026\013\036\020\024 \007\017\r\036\030\021\017\022\031\035\026, \004\ \021\024 \023\024\r\t\001\026\036\021 \220\235\235\036\022\021\017\r\027\ \024\f\021\034 )Tj 0.016 Tw T* [(\023\024\f\035\036\007\031\033\013\036\020\024 )0.5(\220\027\007\024\f\022\024\023\017\004\036\f\022\024\020\024 \020\036\n\024\ \f\021\026\026 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 19.171 0 Td (\f\027\017\032\026)Tj 0 Tw (-)Tj -19.171 -1.218 Td (\036\021 \004\026\f\021\024\021\031 \030\026\027\027\017\b \030\036\006\017\ \007\017\r\024\r \022\030\024\r\024\021\036\004\036\027\017\005 [21].)Tj 0.33 Tw T* (\215\030\017 \022\024\035\024\027\024\f\022\024\023\017\017 \021\024\004\ \027\024\f\021\034 \r\t\016\r\035\036\027\017\016 \017\f\021\024\004\027\ \017\022\026 )Tj 0.062 Tw 0 -1.218 TD (\022\030\024\r\024\021\036\004\036\027\017\016 \022\024\035\036\002\035\036\ \021\f\016 \024\021 52,9 \007\024)Tj /Span<>> BDC ( )Tj EMC (91%, \022\030\024\n\036 \220\021\024)Tj 0 Tw (-)Tj 0.1 Tw 0 -1.218 TD (\020\024, \r)Tj /Span<>> BDC ( )Tj EMC (\024\021\035\017\004\017\036 \024\021 \035\031\004\036\r\t\b \n\036\021\024\ \007\024\r \017\f\f\035\036\007\024\r\026\027\017\016, \022\024)Tj 0 Tw (-)Tj -0.002 Tw T* [(\035\024\027\024\f\022\024\023\017\016 \023\024\r\024\035\016\036\021 )0.5(\024\007\027\024\r\030\036\n\036\027\027\024 \f)]TJ /Span<>> BDC ( )Tj EMC (\007\017\026\020\027\024\f\021\017\022\024\005 )Tj 0.001 Tw T* (\023\026\021\024\035\024\020\017\017 \r\t\023\024\035\027\016\021\034 \220\ \027\007\024\f\022\024\023\017\004\036\f\022\024\036 \035\036\004\036\027\ \017\036 [21]. )Tj 0.022 Tw T* (\215\024)Tj /Span<>> BDC ( )Tj EMC (\f\030\026\r\027\036\027\017\033 \f)Tj /Span<>> BDC ( )Tj EMC (\035\031\004\036\r\t\n\017 \n\036\021\024\007\026\n\017 \007\017\026\020\ \027\024\f\021\017\022\017 \022\024)Tj 0 Tw (-)Tj 0.075 Tw T* (\035\024\027\024\f\022\024\023\017\016 \023\030\024\007\036\n\024\027\f\021\ \030\017\030\024\r\026\035\026 \002\024\035\036\036 \r\t\f\024\022\017\036\ \023\024)Tj 0 Tw (-)Tj 0.227 Tw 0 -1.218 TD (\022\026\026\021\036\035\017 \r\t\016\r\035\036\027\017\016 \021\024\035\ \f\021\024\022\017\001\036\004\027\t\b \022\030\024\r\024\021\036\004\036\ \027\017\005 )Tj 0.109 Tw 0 -1.218 TD (\023\030\017)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\036\036 \027\017\022\017\b \n\036\007\017\006\017\027\f\022\ \017\b \026\021\030\026\021\026\b. \215\024\f\022\024\035\034\022\031 )Tj 0.151 Tw 0 -1.218 TD (\007\017\r\036\030\021\017\022\031\035\016\030\027\024\036 \022\030\024\r\ \024\021\036\004\036\027\017\036 \r)Tj /Span<>> BDC ( )Tj EMC (90% \f\035\031\004\026\036\r \023\030\036)Tj 0 Tw (-)Tj 0.014 Tw T* (\022\030\026\013\026\036\021\f\016 \f\026\n\024\023\030\024\017\r\024\035\ \034\027\024, \007\035\016 \002\024\035\036\036 \220\235\235\036\022\021\ \017\r\027\024)Tj 0 Tw (-)Tj 0.04 Tw T* (\020\024 \r\t\016\r\035\036\027\017\016 \017\f\021\024\004\027\017\022\026\ \021\016\032\036\035\024\020\024 \007\017\r\036\030\021\017\022\031\035\ \016\030\027\024\020\024 )Tj 0.547 Tw T* (\022\030\024\r\024\021\036\004\036\027\017\016 \030\036\022\024\n\036\027\ \007\031\036\021\f\016 \023\030\024\r\036\007\036\027\017\036 \030\026\027\ \027\036\005 )Tj 0.162 Tw T* (\022\024\035\024\027\024\f\022\024\023\017\017)Tj /Span<>> BDC ( )Tj EMC (\227 \r)Tj /Span<>> BDC ( )Tj EMC (\021\036\004\036\027\017\036 12 \004\026\f\024\r \(\031 \027\036\f\021\026\ \002\017\035\034)Tj 0 Tw (-)Tj 0.106 Tw T* (\027\t\b \023\026\006\017\036\027\021\024\r\) [15] \017\035\017 \r)Tj /Span<>> BDC ( )Tj EMC (\021\036\004\036\027\017\036 24 \004\026\f\024\r \(\031 \f\021\026)Tj 0 Tw (-)Tj 0.05 Tw T* [(\002\017\035\034\027\t\b \023\026\006\017\036\027\021\024\r\) )0.5(\023\024\f\035\036 \020\024\f\023\017\021\026\035\017\026\006\017\017 \002\ \024\035\034\027\024\020\024 )]TJ 0.069 Tw T* ([12,22]. \203\026\007\036\032\027\026\016 \017\007\036\027\021\017\235\017\ \022\026\006\017\016 \017\f\021\024\004\027\017\022\026 \022\030\024\r\024\ )Tj 0 Tw (-)Tj 0.144 Tw T* (\021\036\004\036\027\017\016 \007\024\f\021\017\020\026\036\021\f\016 \r\ )Tj /Span<>> BDC ( )Tj EMC (22% \f\035\031\004\026\036\r \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\030\026\027\027\036\005 \022\024)Tj 0 Tw (-)Tj 0.042 Tw T* (\035\024\027\024\f\022\024\023\017\017 \(\004\036\030\036 12 \004\026\f\ \024\r \023\024\f\035\036 \023\024\f\021\031\023\035\036\027\017\016\), \ \004\021\024 )Tj 0.102 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC 0.809 0 Td [(7,5 )0.5(\030\026 )0.5(\004\026\013\036, )0.5(\004\036\n )0.5(\004\036\030\036 )0.5(24 \004\026\f\026 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 14.707 0 Td [(\r )0.5(22 \030\026\026 )0.5(\004\026\013\036, )]TJ -0.019 Tw -15.516 -1.218 Td (\004\036\n \004\036\030\036 48 \004\026\f\024\r \023\024\f\035\036 \023\ \024\f\021\031\023\035\036\027\017\016 \002\024\035\034\027\024\020\024 \ [23]. )Tj 0.217 Tw T* (\224\017\f\021\036\n\026\021\017\004\036\f\022\017\036 \024\002\024\030\ \t \f)Tj /Span<>> BDC ( )Tj EMC (\n\036\021\026\026\027\026\035\017\024\n \023\024\022\026\026\035\017,\ )Tj 0.016 Tw T* (\004\021\024 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\r\t\023\024\035\027\036\027\017\017 \030\026\027\027\036\005 \022\024\035\ \024\027\024\f\022\024\023\017\017 \024\021\n\036\004\026\036\021)Tj 0 Tw (-)Tj -0.016 Tw T* (\f\016 \027\026\004\017\021\036\035\034\027\024 \002\024\035\036\036 \r\ \t\f\024\022\026\016 \004\026\f\021\024\021\026 \r\t\016\r\035\036\027\017\ \016 \035\024)Tj 0 Tw (-)Tj 0.169 Tw T* [(\022\026\035\017\026\006\017\017 )0.5(\n\036\f\021\026 \022\030\024\r\024\021\036\004\036\027\017\016 [20,24],\ \f\024\022\030\026\013\036\027\017\036 )]TJ 0.256 Tw T* (\f\030\024\022\024\r \f\021\026\006\017\024\027\026\030\027\024\020\024 \ \035\036\004\036\027\017\016 \017)Tj /Span<>> BDC ( )Tj EMC (\f\027\017\032\036\027\017\036 \024\002\013\017\b )Tj 0.172 Tw T* (\n\036\007\017\006\017\027\f\022\017\b \026\021\030\026\021 \027\026)Tj /Span<>> BDC ( )Tj EMC (\035\036\004\036\027\017\036 \002\024\035\034\027\t\b \002\036 \f\031\013\ \036)Tj 0 Tw (-)Tj 0.138 Tw T* [(\f\021\r\036\027\027\024\005 )0.5(\030\026\027\017\006\t \r)]TJ /Span<>> BDC ( )Tj EMC 8.929 0 Td [(\004\026\f\021\024\021\036 )0.5(\024\f\035\024\032\027\036\027\017\005 \017)]TJ /Span<>> BDC ( )Tj EMC 9.822 0 Td (\030\036\006\017\007\017)Tj 0 Tw (-)Tj 0.009 Tw -18.75 -1.218 Td (\r\024\r \022\030\024\r\024\021\036\004\036\027\017\016, \023\024\021\030\ \036\002\027\024\f\021\017 \r)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\036\035\017\r\026\027\017\017 \022\030\024\r\017 )Tj 0 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\023\024\022\026\026\021\036\035\016\b \f\n\036\030\021\027\024\f\021\017\ [27,28].)Tj 0.206 Tw T* (\212\035\016 \023\024\007\020\024\021\024\r\022\017 \022\017\001\036\004\ \027\017\022\026 \022)Tj /Span<>> BDC ( )Tj EMC (\022\024\035\024\027\024\f\022\024\023\017\017 \023\024)Tj /Span<>> BDC ( )Tj EMC (\023\024)Tj 0 Tw (-)Tj 0.242 Tw T* (\r\024\007\031 \021\024\035\f\021\024\022\017\001\036\004\027\t\b \022\030\ \024\r\024\021\036\004\036\027\017\005 \030\036\022\024\n\036\027\007\031\ \036\021\f\016 )Tj 0.205 Tw T* (\017\f\023\024\035\034\024\r\026\021\034 \f\021\026\027\007\026\030\021\ \027\t\036 \030\026\f\021\r\024\030\t \007\035\016 \024\030\026\035\034\027\ \024\020\024 )Tj 0.165 Tw T* (\035\026\r\026\032\026, \026)Tj /Span<>> BDC ( )Tj EMC (\017\f\022\035\033\004\036\027\017\036\n \023\026\006\017\036\027\021\024\ \r, \031)Tj /Span<>> BDC ( )Tj EMC (\022\024\021\024\030\t\b \036\f\021\034 )Tj 0.196 Tw T* (\023\030\024\021\017\r\024\023\024\022\026\026\027\017\016 \022)Tj /Span<>> BDC ( )Tj EMC (\036\020\024 \023\030\017\n\036\027\036\027\017\033 [12]. \232\026\f\021\ \024\021\026 )Tj 0.797 Tw T* (\027\036\032\036\035\026\021\036\035\034\027\t\b \023\024\002\024\004\027\ \t\b \220\235\235\036\022\021\024\r, \f\r\016\026\027\027\t\b )Tj 0.365 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\023\030\017\036\n\024\n \f\030\036\007\f\021\r \007\035\016 \024\030\026\ \035\034\027\024\020\024 \035\026\r\026\032\026, \f\031\013\036)Tj 0 Tw (-)Tj 0.147 Tw T* (\f\021\r\036\027\027\024 \027\036 \030\026\035\017\004\026\036\021\f\016\ \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\024\002\f\035\036\007\024\r\026\027\017\017 \002\024\035\034\027\t\b )Tj 0.122 Tw T* (\023\024)Tj /Span<>> BDC ( )Tj EMC (\023\024\r\024\007\031 \024\f\021\030\t\b \020\026\f\021\030\024\017\027\ \021\036\f\021\017\027\026\035\034\027\t\b \022\030\024\r\024\021\036\004\ \036)Tj 0 Tw (-)Tj 0.215 Tw T* (\027\017\005 [29]. \211)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \f\024 \f\021\026\002\017\035\034\027\ \024\005 \020\036\n\024\007\017\027\026\n\017)Tj 0 Tw (-)Tj 0.101 Tw T* (\022\024\005 \022\024\035\024\027\024\f\022\024\023\017\016 \n\024\032\036\ \021 \002\t\021\034 \r\t\023\024\035\027\036\027\026 \r)Tj /Span<>> BDC ( )Tj EMC (\021\036\004\036\027\017\036 )Tj 0.209 Tw T* (24)Tj /Span<>> BDC ( )Tj EMC (\004\026\f\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\017\f\023\024\035\034\024\r\026\027\017\036\n \024\002\t\004\027\024\005\ \f\b\036\n\t \023\024\007\020\024)Tj 0 Tw (-)Tj 0.148 Tw T* (\021\024\r\022\017 \022\017\001\036\004\027\017\022\026 \(\030\026\007\036\ \035\036\027\027\026\016 \007\024\017\030\024\r\022\026 \023\030\036\023\ \026\030\026)Tj 0 Tw (-)Tj 0.244 Tw T* (\021\026\) [15]. \224\031\013\036\f\021\r\031\033\021 \030\036\022\024\n\ \036\027\007\026\006\017\017 \023\024)Tj /Span<>> BDC ( )Tj EMC (\023\024\007\020\024\021\024\r\022\036 )Tj 0.145 Tw T* (\022)Tj /Span<>> BDC ( )Tj EMC (\030\026\027\027\036\005 \022\024\035\024\027\024\f\022\024\023\017\017 \ \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\024\f\021\030\t\b \212\230\025 \023\031\021\036\n \r\r\036)Tj 0 Tw (-)Tj 0.114 Tw T* (\007\036\027\017\016 4\2266)Tj /Span<>> BDC ( )Tj EMC (\035 \030\026\f\021\r\024\030\026 \023\024\035\017\220\021\017\035\036\027\ \020\035\017\022\024\035\016 \r)Tj /Span<>> BDC ( )Tj EMC (\021\036\004\036\027\017\036 )Tj 0.201 Tw T* (3\2264)Tj /Span<>> BDC ( )Tj EMC 1.989 0 Td [(\004\026\f\024\r )0.5(\007\024)]TJ /Span<>> BDC ( )Tj EMC 4.206 0 Td [(\021\036\b )0.5(\023\024\030, )0.6(\023\024\022\026 )0.5(\030\036\022\021\026\035\034\027\t\036 )0.6(\r\t\007\036\035\036\027\017\016 )]TJ 0.304 Tw -6.195 -1.218 Td (\027\036 \f\021\026\027\031\021 \023\030\024\030\026\004\027\t\n\017 [2\ 8]. \236\n\036\033\021\f\016 \f\024\024\002\013\036\027\017\016 )Tj 0.58 Tw T* (\024)Tj /Span<>> BDC ( )Tj EMC (\r\024\n\024\032\027\024\f\021\016\b \002\t\f\021\030\024\020\024 \024\004\ \017\013\036\027\017\016 \022\017\001\036\004\027\017\022\026 )Tj 0.143 Tw 23.244 64.543 Td (\023\036\030\036\007 \f\030\024\004\027\024\005 \022\024\035\024\027\024\ \f\022\024\023\017\036\005 \027\026)Tj /Span<>> BDC ( )Tj EMC (\024\f\027\024\r\036 \017\f\023\024\035\034\024)Tj 0 Tw (-)Tj 0.093 Tw T* (\r\026\027\017\016 \n\026\035\024\024\002\255\036\n\027\t\b \f\b\036\n \023\ \024\007\020\024\021\024\r\022\017: 1 \035 \030\026\f\021\r\024\030\026 \ )Tj 0.5 Tw T* (\023\024\035\017\220\021\017\035\036\027\020\035\017\022\024\035\034-\026\ \f\022\024\030\002\026\021\026 \(NER1006\) \r\r\024\007\017\021\f\016 )Tj 0.042 Tw T* [(\004\036\030\036 )0.5(\027\026\024\020\026\f\021\030\026\035\034\027\t\005 )0.5(\024\027\007 )0.6(\f)]TJ /Span<>> BDC ( )Tj EMC 12.877 0 Td [(\023\024\f\035\036\007\031\033\013\017\n )0.6(\026\023\017\r\026)]TJ 0 Tw (-)Tj 0.092 Tw -12.877 -1.218 Td (\027\017\036\n \024\007\027\017\n \035\017\021\030\024\n \r\024\007\t \r\ )Tj /Span<>> BDC ( )Tj EMC (\021\036\004\036\027\017\036 2 \004\026\f\024\r [29,30]. )Tj 0.107 Tw T* [(\204\036\021\026\026\027\026\035\017 \022\035\017\027\017\004\036\f\022\ \017\b )0.5(\017\f\f\035\036\007\024\r\026\027\017\005 \023\024\022\026\026\035, \004\ \021\024 )]TJ 0.124 Tw 0 -1.218 TD (\023\030\036\023\026\030\026\021 NER1006 \024\002\036\f\023\036\004\017\r\ \026\036\021 \002\024\035\036\036 \r\t\f\024\022\017\005 \024\002)Tj 0 Tw (-)Tj 0.131 Tw 0 -1.218 TD (\013\017\005 \031\030\024\r\036\027\034 \024\004\017\013\036\027\017\016\ \023\024)Tj /Span<>> BDC ( )Tj EMC (\f\030\026\r\027\036\027\017\033 \f)Tj /Span<>> BDC ( )Tj EMC (\021\030\026\007\017\006\017\024\027)Tj 0 Tw (-)Tj 0.08 Tw T* (\027\t\n\017 \023\030\036\023\026\030\026\021\026\n\017, \r)Tj /Span<>> BDC ( )Tj EMC (\021\024\n \004\017\f\035\036)Tj /Span<>> BDC ( )Tj EMC (\227 \002\024\035\036\036 \022\026\004\036\f\021\r\036\027)Tj 0 Tw (-)Tj 0.338 Tw T* (\027\024\036 \024\004\017\013\036\027\017\036 \023\030\026\r\024\005 \004\ \026\f\021\017 \021\024\035\f\021\024\005 \022\017\001\022\017 [31]. )Tj -0.005 Tw T* (\025\024\035\024\027\024\f\022\024\023\017\016 \002\036 \023\024\007\020\ \024\021\024\r\022\017 \022\017\001\036\004\027\017\022\026 \023\030\017\ )Tj /Span<>> BDC ( )Tj EMC (\024\f\021\030\t\b )Tj 0.36 Tw T* [(\021\024\035\f\021\024\022\017\001\036\004\027\t\b )0.6(\022\030\024\r\024\021\036\004\036\027\017\016\b )0.6(\027\036 )0.5(\030\036\022\024\n\036\027\007\031\036\021\f\016, )]TJ 0.015 Tw 0 -1.218 TD (\023\024\f\022\024\035\034\022\031 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\n \004\026\f\021\024\021\026 \017\027\021\031\002\026\006\017\ \017 \f\035\036\023\024\005 \022\017\001\022\017 )Tj -0.006 Tw 0 -1.218 TD (\017)Tj /Span<>> BDC ( )Tj EMC (\007\017\026\020\027\024\f\021\017\004\036\f\022\017\036 \030\036\031\035\ \034\021\026\021\t \027\017\022\017\036, \026)Tj /Span<>> BDC ( )Tj EMC (\023\035\024\b\026\016 \r\017\031)Tj 0 Tw (-)Tj 0.017 Tw 0 -1.218 TD (\026\035\017\026\006\017\016 \n\024\032\036\021 \031\r\036\035\017\004\017\ \021\034 \030\017\f\022 \023\036\030\235\024\030\026\006\017\017 \021\024\ \035\f\021\024\005 )Tj 0 Tw T* (\022\017\001\022\017 [28].)Tj 0.244 Tw T* (\212\035\016 \r\t\016\r\035\036\027\017\016 \017\f\021\024\004\027\017\022\ \026 \022\030\024\r\024\021\036\004\036\027\017\016 \r)Tj /Span<>> BDC ( )Tj EMC (\027\036\002\024\035\034)Tj 0 Tw (-)Tj 0.391 Tw T* (\001\017\b \007\017\r\036\030\021\017\022\031\035\026\b \023\030\036\007\ \035\026\020\026\036\021\f\016 \017\f\023\024\035\034\024\r\026\021\034\ \031\007)Tj 0 Tw (-)Tj 0.16 Tw T* (\035\017\027\036\027\027\t\005 \220\027\007\024\f\022\024\023\017\004\036\ \f\022\017\005 \022\024\035\023\026\004\024\022 \017\035\017 \022\024\035\ \023\026\004\024\022 )Tj 0.094 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\026\024\f\021\030\036\027\027\t\n \027\026\022\024\027\036\004\027\017\ \022\024\n \n\026\035\024\020\024 \007\017\026\n\036\021\030\026 4 \n\n \ )Tj 0.219 Tw T* [(\(C)20(A)35(S)-21(T)47(ho)-16(od\) [17,32,33]. \236\027\024\020\007\026 \021\030\026\007\017\006\017\024\ \027\027\t\036 \220\027\007\024)]TJ 0 Tw (-)Tj -0.051 Tw T* [(\f\022\024\023\017\004\036\f\022\017\036 )0.5(\n\036\021\024\007\t \027\036 )0.5(\023\024\r\024\035\016\033\021 )0.5(\007\024\f\021\017\004\034 \n\036\f\021\026 )0.5(\022\030\024)]TJ 0 Tw (-)Tj -0.012 Tw T* (\r\024\021\036\004\036\027\017\016 \r)Tj /Span<>> BDC ( )Tj EMC (\023\030\026\r\024\005 \023\024\035\024\r\017\027\036 \021\024\035\f\021\ \024\005 \022\017\001\022\017. \200)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\017\b )Tj 0.114 Tw T* (\f\017\021\031\026\006\017\016\b \007\035\016 \r\t\023\024\035\027\036\027\ \017\016 \021\024\021\026\035\034\027\024\005 \022\024\035\024\027\024\f\ \022\024\023\017\017 )Tj 0.225 Tw T* [(\023\030\036\007\035\026\020\026\036\021\f\016 )0.6(\017\f\023\024\035\034\024\r\026\021\034 )0.5(\021\036\b\027\017\022\031 )0.6(\024\007\027\024\002\026\035\035\024\027\027\024\005 )]TJ 0.197 Tw T* [(\220\027\007\024\f\022\024\023\017\017 )0.6([34]. )0.5(\202\022\021\017\r\027\024\036 )0.6(\022\030\024\r\024\021\036\004\036\027\017\036 )0.5(\r\024 )0.6(\r\030\036\n\016 )]TJ 0.066 Tw T* [(\f\030\024\004\027\024\005 \022\024\035\024\027\024\f\022\024\023\017\017\ \026\021\030\031\007\027\016\036\021 )0.5(\021\024\004\027\024\036 \024\023\030\036\007\036\035\036)]TJ 0 Tw (-)Tj 0.086 Tw T* [(\027\017\036 )0.5(\017\f\021\024\004\027\017\022\026 )0.5(\022\030\024\r\024\021\036\004\036\027\017\016 )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC 13.268 0 Td [(\023\024\f\035\036\007\031\033\013\036\036 )0.6(\r\t\023\024\035)]TJ 0 Tw (-)Tj -0.028 Tw -13.268 -1.218 Td (\027\036\027\017\036 \220\027\007\024\f\022\024\023\017\004\036\f\022\024\ \020\024 \020\036\n\024\f\021\026\026. \212\035\016 \035\024\022\026\035\ \017\026\006\017\017 )Tj -0.011 Tw T* (\017\f\021\024\004\027\017\022\026 \022\030\024\r\024\021\036\004\036\027\ \017\016 \r)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\017\b \f\017\021\031\026\006\017\016\b \017\f\023\024\035\034\ \031)Tj 0 Tw (-)Tj 0.013 Tw T* (\036\021\f\016 \n\036\021\024\007\017\022\026 \024\f\n\024\021\030\026 \f\ )Tj /Span<>> BDC ( )Tj EMC (\023\024\020\030\031\032\036\027\017\036\n \024\027\t \022\030\024\r\024\ \021\024)Tj 0 Tw (-)Tj -0.013 Tw T* (\004\026\013\036\020\024 \007\017\r\036\030\021\017\022\031\035\026 \023\ \024\007 \r\024\007\031 [12,35]. \212\035\016 \031\035\031\004\001\036\027\ \017\016 )Tj 0.158 Tw T* (\220\027\007\024\f\022\024\023\017\004\036\f\022\024\005 \r\017\031\026\ \035\017\026\006\017\017 \017\f\021\024\004\027\017\022\026 \007\017\r\036\ \030\021\017)Tj 0 Tw (-)Tj 0.136 Tw T* [(\022\031\035\016\030\027\024\020\024 )0.5(\022\030\024\r\024\021\036\004\036\027\017\016 )0.6(\023\030\036\007\035\026\020\026\036\021\f\016 )0.6(\017\f\023\024\035\034\024\r\026\021\034 )]TJ 0.286 Tw T* [(\020\036\035\036\r\t\036 \022\024\n\023\024\017\006\017\017 \(OS-1, VIS\ C)13(OCLEAR\), \r\r\036\007\036\027\017\036 )]TJ 0.095 Tw T* (\022\024\021\024\030\t\b \r)Tj /Span<>> BDC ( )Tj EMC (\024\002\035\026\f\021\034 \024\002\f\035\036\007\031\036\n\t\b \007\017\ \r\036\030\021\017\022\031\035\024\r \024\002\036\f)Tj /Span<>> BDC (-)Tj EMC 0.315 Tw T* (\023\036\004\017\r\026\036\021 \002\024\035\036\036 \004\036\021\022\024\ \036 \017\024\002\030\026\032\036\027\017\036 \017)Tj /Span<>> BDC ( )Tj EMC (\031\n\036\027\034\001\026\036\021 )Tj 0.108 Tw T* [(\024\021\030\026\032\036\027\017\036 )0.5(\f\r\036\021\026. \207\024\035\036\036 )0.5(\r\t\f\024\022\026\016 \r\016\022\024\f\021\034 )0.5(\020\036\035\016 \023\030\036)]TJ 0 Tw (-)Tj 0.214 Tw T* [(\007\024\021\r\030\026\013\026\036\021 )0.5(\f\n\036\001\017\r\026\027\017\036 )0.5(\020\036\035\016 \f)]TJ /Span<>> BDC ( )Tj EMC 13.904 0 Td [(\022\030\024\r\034\033, )0.5(\021\036\n \f\026\n\t\n )]TJ 0.498 Tw -13.904 -1.218 Td (\023\024\n\024\020\026\016 \r\017\031\026\035\017\017\030\024\r\026\021\ \034 \017\f\021\024\004\027\017\022 \022\030\024\r\024\021\036\004\036\027\ \017\016 )Tj 0.033 Tw T* [([36,37]. \200\017\007\036\024\022\024\035\024\027\024\f\022\024\023 EVIS\ X1 \(Ol)35.1(ym)10(pus\) \024\f\027\026\013\036\027 )]TJ 0.412 Tw T* [(\030\036\032\017\n\024\n )0.5(\022\030\026\f\027\024\005 )0.6(\007\017\b\030\024\n\026\021\017\004\036\f\022\024\005 )0.6(\r\017\031\026\035\017\026\006\017\017 )]TJ 0.135 Tw T* [(\(r)-24(ed dichr)-32(oma)15(t)-31.9(ic ima)-16.9(ging)]TJ /Span<>> BDC ( )Tj EMC (\227 RDI\). \225\021\026 \220\027\007\024\f\022\024\023\017\004\036)Tj 0 Tw (-)Tj 0.316 Tw T* (\f\022\026\016 \021\036\b\027\024\035\024\020\017\016 \031\035\031\004\001\ \026\036\021 \r\017\031\026\035\017\026\006\017\033 \020\035\031\002\024\ \022\017\b )Tj 0.365 Tw T* [(\022\030\024\r\036\027\024\f\027\t\b )0.5(\f\024\f\031\007\024\r \017)]TJ /Span<>> BDC ( )Tj EMC (\017\f\021\024\004\027\017\022\024\r \022\030\024\r\024\021\036\004\036\027\ \017\016 )Tj -0.042 Tw T* (\002\035\026\020\024\007\026\030\016 \017\f\023\024\035\034\024\r\026\027\ \017\033 \030\026\035\017\004\027\024\005 \f\023\036\006\017\235\017\004\ \036\f\022\024\005 )Tj 0.196 Tw T* (\007\035\017\027\t \r\024\035\027 \036\035\201\027\024\020\024, \016\027\ \021\026\030\027\024\020\024 \017)Tj /Span<>> BDC ( )Tj EMC (\022\030\026\f\027\024\020\024 \006\r\036\021\026. )Tj -0.01 Tw T* (\233\027\021\026\030\027\t\005 \f\r\036\021 \035\036\020\004\036 \023\024\ \020\035\024\013\026\036\021\f\016 \020\036\n\024\020\035\024\002\017\027\ \024\n \022\030\024)Tj 0 Tw (-)Tj 0.087 Tw T* (\r\017, \004\021\024 \024\002\035\036\020\004\026\036\021 \024\002\027\026\ \030\031\032\036\027\017\036 \n\036\f\021\026 \022\030\024\r\024\021\036\ \004\036\027\017\016. )Tj 0.015 Tw T* (\025\030\024\n\036 \220\021\024\020\024, \017\f\023\024\035\034\024\r\026\ \027\017\036 \016\027\021\026\030\027\024\020\024 \f\r\036\021\026 \f\023\ \024\f\024\002)Tj 0 Tw (-)Tj 0.028 Tw T* [(\f\021\r\031\036\021 )0.5(\f\027\017\032\036\027\017\033 )0.6(\023\f\017\b\024\035\024\020\017\004\036\f\022\024\020\024 )0.6(\f\021\030\036\f\f\026 )0.5(\031)]TJ /Span<>> BDC ( )Tj EMC 19.216 0 Td (\r\030\026\004\036\005 )Tj 0.119 Tw -19.216 -1.218 Td (\r\024 \r\030\036\n\016 \r\t\023\024\035\027\036\027\017\016 \023\030\024\ \006\036\007\031\030\t, \004\021\024 \023\024\021\036\027\006\017\026\035\ \034\027\024 )Tj 0.127 Tw T* (\031\035\031\004\001\026\036\021 \220\235\235\036\022\021\017\r\027\024\f\ \021\034 \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\022\030\026\013\026\036\021 \r\030\036\n\016 \023\030\024\r\036)Tj 0 Tw (-)Tj T* (\007\036\027\017\016 \220\027\007\024\f\022\024\023\017\004\036\f\022\024\ \020\024 \020\036\n\024\f\021\026\026 [38,39].)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\206)10(\002\036\033 \035\030\032\003\033)30(\n)42(\032)-21(\230\033\241)]TJ 57.136 0 Td (REVIEW)Tj -57.136 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 2)69(4, \023\0224, 202)23(5)]TJ 43.013 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 2)69(4, \023\0224, 202)23(5)]TJ /T1_2 1 Tf 25 0 0 25 20.7653 56.0378 Tm (212)Tj ET endstream endobj 101 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\240\021\001\202\215\025\b)-9.9(\026\021\017\001 \211\021\r\016\201\026\021\017\200\t\004\201\215\220 \026\ )11.1(\025\t\b)-10(\026)11(\025\017\021\020\016\f\215\220 )]TJ 0 -1 TD [(\017\201\025\r\025\026)11(\016\f\016\215\021\207 \(\025\235\213\025\201 \t\021\026)11(\016\201\001\026)-19.9(\200\201\220\))]TJ 39.93 1 Td [(Diagnostics of\022div)12.1(er)-20(ticular colonic bleeding \(r)31(e)11(vie)11(w\))]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0.115 Tw 10 0 0 10 42.5197 724.8299 Tm [(\002\026\026\n \007\026\027\027\t\b eL)-31.9(ibr)-33(ar)-24(y.r)-21.9(u, P)20(ubMed \017)]TJ /Span<>> BDC ( )Tj EMC [(Co)-16(chr)-33(aneL)-32(ibr)-32.9(ar)-24(y )]TJ 0.162 Tw 0 -1.218 TD (\026)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\017\024\007 \f)Tj /Span<>> BDC ( )Tj EMC (2005 \023\024)Tj /Span<>> BDC ( )Tj EMC (2025 \020\020. \212\035\016 \f\002\024\030\026 \024\023\031\002\035\017\022\ \024)Tj 0 Tw (-)Tj 0.324 Tw T* (\r\026\027\027\t\b \007\026\027\027\t\b \017\f\023\024\035\034\024\r\026\ \035\017\f\034 \023\024\017\f\022\024\r\t\036 \026\023\030\024)Tj 0 Tw (-)Tj -0.022 Tw T* (\f\t)Tj /Span<>> BDC ( )Tj EMC [(\227 col)30.1(onic bleeding OR col)30(onic di)-16(ver)-21.9(t)-32(icul)-16(ar bleeding )]TJ 0.334 Tw T* [(A)51(ND col)30(onoscopy A)51.1(ND contr)-33(ast-enhanced com)10(puted )]TJ 0.3 Tw T* [(t)17(omo)-16(gr)-33(aphy A)51(ND ar)-22(ter)-36.9(io)-16(gr)-33(aphy A)51.1(ND tr)-33(ansabd)-16(ominal )]TJ 0.026 Tw 0 -1.218 TD [(ul)56(tr)-32.9(asound A)51(ND techne)-12(t)-32(ium-99m-t)15.1(a)-17(gged r)-24(ed bl)30(o)-16(od cell )]TJ 0.142 Tw 0 -1.218 TD (scanning. \215\036\030\r\017\004\027\024 \002\t\035\024 \027\026\005\007\ \036\027\024 832 \023\031\002\035\017\022\026\006\017\017. )Tj 0.069 Tw T* (\200)Tj /Span<>> BDC ( )Tj EMC [(\002\026\036 eL)-32(ibr)-32.9(ar)-24(y.r)-22(u \023\024)]TJ /Span<>> BDC ( )Tj EMC (\026\023\030\024\f\031 \253\021\024\035\f\021\024\022\017\001\036\004\027\ \t\036 \022\030\024)Tj 0 Tw (-)Tj 0.318 Tw T* (\r\024\021\036\004\036\027\017\016\273 \017\n\036\036\021\f\016 4 \024\021\ \036\004\036\f\021\r\036\027\027\t\036 \023\031\002\035\017\022\026\006\017\ \017. )Tj 0.192 Tw T* (\215\024\f\035\036 \f\022\030\017\027\017\027\020\026 \017)Tj /Span<>> BDC ( )Tj EMC (\024\006\036\027\022\017 \030\036\033\n\036 \f)Tj /Span<>> BDC ( )Tj EMC (\023\024\f\035\036\007\031\033\013\017\n )Tj 0.36 Tw T* (\017\031\004\036\027\017\036\n \023\024\035\027\t\b \021\036\022\f\021\024\ \r \f\021\026\021\036\005 \002\t\035\024 \024\021\024\002\030\026\027\024\ )Tj 0.073 Tw 0 -1.218 TD (66)Tj /Span<>> BDC ( )Tj EMC (\023\031\002\035\017\022\026\006\017\005, \f\030\036\007\017 \027\017\b)Tj /Span<>> BDC ( )Tj EMC (\227 4 \n\036\021\026\026\027\026\035\017\026, 5 \024\002\024)Tj 0 Tw (-)Tj 0.255 Tw 0 -1.218 TD [(\030\024\r, )0.5(34 )0.5(\022\035\017\027\017\004\036\f\022\017\b )0.5(\017\f\f\035\036\007\024\r\026\027\017\016, )0.6(5 )0.5(\022\035\017\027\017\004\036\f\022\017\b )]TJ 0 Tw 0 -1.218 TD (\030\036\022\024\n\036\027\007\026\006\017\005 \(\217\017\f.)Tj /Span<>> BDC ( )Tj EMC (1\).)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 42.5896 517.8038 Tm [(\033\034\020)21(\223)50(\r\237)46(\024)52(\026)45(\024\232)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0 Tc 0.284 Tw 10 0 0 10 42.5197 493.4478 Tm [(\202\027\026\021\024\n\017\004\036\f\022\017 )0.6(\r)]TJ /Span<>> BDC ( )Tj EMC 7.357 0 Td [(\007\017\r\036\030\021\017\022\031\035\026\b )0.6(\021\024\035\f\021\024\005 )0.5(\022\017\001\022\017 )0.5(\030\026)]TJ 0 Tw (-)Tj 0.062 Tw -7.357 -1.218 Td (\035\017\004\026\033\021 \031\f\021\034\036, \001\036\005\022\031, \021\036\ \035\024 \017)Tj /Span<>> BDC ( )Tj EMC (\007\027\024. \204\036\b\026\027\017\n \030\026\r\017\021\017\016 )Tj 0.029 Tw T* (\022\030\024\r\024\021\036\004\036\027\017\016 \017)Tj /Span<>> BDC ( )Tj EMC (\007\017\r\036\030\021\017\022\031\035\024\r \021\024\035\f\021\024\005 \ \022\017\001\022\017 \f\024\f\021\024)Tj 0 Tw (-)Tj 0.161 Tw T* (\017\021 \r)Tj /Span<>> BDC ( )Tj EMC (\021\024\n, \004\021\024 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\220\r\026\022\031\026\006\017\017 \235\036\022\026\035\017\021\026 \004\ \036\030\036 \001\036\005\022\031 )Tj 0.046 Tw T* (\007\017\r\036\030\021\017\022\031\035\026 \r)Tj /Span<>> BDC ( )Tj EMC (\036\201 \031\022\024\005 \004\026\f\021\017 \023\030\024\017\f\b\024\007\ \017\021 \023\024\r\030\036\032\007\036)Tj 0 Tw (-)Tj 0.15 Tw T* (\027\017\036 \030\t\b\035\024\005 \024\021\201\004\027\024\005 \f\035\017\ \017\f\021\024\005 \024\002\024\035\024\004\022\017 \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\036\007\035\036)Tj 0 Tw (-)Tj 0.11 Tw T* (\032\026\013\017\b \022)Tj /Span<>> BDC ( )Tj EMC (\027\036\005 \r\036\021\r\036\005 \023\030\016\n\t\b \f\024\f\031\007\024\ \r \021\024\035\f\021\024\005 \022\017\001\022\017 )Tj 0.058 Tw T* ([10]. \212\017\r\036\030\021\017\022\031\035\016\030\027\024\036 \022\030\ \024\r\024\021\036\004\036\027\017\036 \024\002\t\004\027\024 \023\030\024\ \016\r)Tj 0 Tw (-)Tj 0.063 Tw T* (\035\016\036\021\f\016 \r)Tj /Span<>> BDC ( )Tj EMC (\r\017\007\036 \002\036\002\024\035\036\027\036\027\027\024\005 \020\036\ \n\026\021\024\b\036\017\017)Tj /Span<>> BDC ( )Tj EMC (\227 \023\036\030\026)Tj 0 Tw (-)Tj 0.086 Tw T* (\027\026\035\034\027\024\020\024 \r\t\007\036\035\036\027\017\016 \f\r\036\ \032\036\005 \022\030\024\r\017 \r)Tj /Span<>> BDC ( )Tj EMC (\f\021\031\035\036 \r\024 \r\030\036\n\016 )Tj 0.144 Tw T* (\007\036\235\036\022\026\006\017\017. \206\036\n\026\021\024\b\036\017\016\ \r\t\t\r\026\036\021 \f\036\030\034\036\027\t\036 \023\024\007\024)Tj 0 Tw (-)Tj 0.078 Tw T* (\030\036\027\017\016 \027\026)Tj /Span<>> BDC ( )Tj EMC (\017\f\021\024\004\027\017\022 \022\030\024\r\024\021\036\004\036\027\017\ \016 \r)Tj /Span<>> BDC ( )Tj EMC (\027\017\032\027\017\b \024\021\007\036\035\026\b )Tj 0.28 Tw T* (\032\036\035\031\007\024\004\027\024-\022\017\001\036\004\027\024\020\024\ \021\030\026\022\021\026. \210\007\027\026\022\024 \023\036\030\026\027\ \026\035\034\027\024\036 )Tj 0.009 Tw T* (\r\t\007\036\035\036\027\017\036 \n\026\035\024\017\n\036\027\036\027\027\ \024\005 \022\030\024\r\017 \021\026\022\032\036 \n\024\032\036\021 \002\ \t\021\034 )Tj 0.228 Tw T* (\023\030\024\016\r\035\036\027\017\036\n \n\026\f\f\017\r\027\024\020\024\ \022\030\024\r\024\021\036\004\036\027\017\016 \017)Tj /Span<>> BDC ( )Tj EMC (\r\036\030\b\027\017\b )Tj 0.05 Tw T* (\024\021\007\036\035\024\r \032\036\035\031\007\024\004\027\024-\022\017\ \001\036\004\027\024\020\024 \021\030\026\022\021\026. \200)Tj /Span<>> BDC ( )Tj EMC (\030\026\027\007\024\n\017\017)Tj 0 Tw (-)Tj -0.086 Tw T* (\030\024\r\026\027\027\024\n \022\024\027\021\030\024\035\017\030\031\036\ \n\024\n \017\f\f\035\036\007\024\r\026\027\017\017 \031)Tj /Span<>> BDC ( )Tj EMC (13 \(15,3%\) )Tj 0.523 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC 1.7 0 Td (85)Tj /Span<>> BDC ( )Tj EMC 1.756 0 Td [(\023\026\006\017\036\027\021\024\r )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC 6.27 0 Td [(\n\027\024\032\036\f\021\r\036\027\027\t\n\017 )0.6(\220\023\017\024\007\026\n\017 )]TJ 0.195 Tw 13.518 43.841 Td (\021\016\032\036\035\024\005 \020\036\n\026\021\024\b\036\017\017 \002\t\ \035\024 \r\t\016\r\035\036\027\024 \022\030\024\r\024\021\036\004\036\027\ \017\036 )Tj 0.521 Tw 0 -1.218 TD (\017)Tj /Span<>> BDC ( )Tj EMC (\r\036\030\b\027\017\b \024\021\007\036\035\024\r \032\036\035\031\007\024\ \004\027\024-\022\017\001\036\004\027\024\020\024 \021\030\026\022)Tj 0 Tw (-)Tj 0.108 Tw 0 -1.218 TD (\021\026 [11]. \200)Tj /Span<>> BDC ( )Tj EMC (\f\r\016\017 \f)Tj /Span<>> BDC ( )Tj EMC (\220\021\017\n, \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\023\024\f\021\031\023\035\036\027\017\017 \023\026\006\017\036\027\021\024\ \r )Tj 0.098 Tw 0 -1.218 TD (\f)Tj /Span<>> BDC ( )Tj EMC [(\021\016\032\036\035\024\005 \020\036\n\026\021\024\b\036\017\036\005 )0.5(\027\036\024\002\b\024\007\017\n\024 \023\036\030\r\024\027\026\004\026\035\ \034\027\024 )]TJ 0.138 Tw 0 -1.218 TD [(\017\f\022\035\033\004\017\021\034 \r\036\030\b\027\017\036 \022\030\024\ \r\024\021\036\004\036\027\017\016 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC (\032\036\035\031\007\024\004\027\024-\022\017)Tj 0 Tw (-)Tj 0.294 Tw 0 -1.218 TD (\001\036\004\027\024\020\024 \021\030\026\022\021\026 \023\031\021\036\n\ \031\f\021\026\027\024\r\022\017 \027\026\024\020\026\f\021\030\026\035\ \034\027\024\020\024 )Tj 0.244 Tw 0 -1.218 TD [(\024\027\007\026 \017\035\017 \r\t\023\024\035\027\036\027\017\016 )0.5(\f\030\024\004\027\024\005 \220\024\235\026\020\024\020\026\f\021\030\024\ \007\031\024)]TJ 0 Tw (-)Tj 0.119 Tw 0 -1.218 TD [(\007\036\027\024\f\022\024\023\017\017, )0.6(\024\023\030\036\007\036\035\036\027\017\016 )0.5(\f\024\024\021\027\024\001\036\027\017\016 )0.6(\023\024\022\026\026\021\036\035\036\005 )]TJ 0.131 Tw T* (\n\024\004\036\r\017\027\t \017)Tj /Span<>> BDC ( )Tj EMC (\022\030\036\026\021\017\027\017\027\026 \r)Tj /Span<>> BDC ( )Tj EMC (\f\t\r\024\030\024\021\022\036 \022\030\024\r\017 [12,13]. )Tj 0.018 Tw T* (\211\n\036\027\034\001\036\027\017\036 \023\024\004\036\004\027\024\020\024\ \022\030\024\r\024\021\024\022\026 \r\f\035\036\007\f\021\r\017\036 \024\ \f\021\030\024\005 )Tj 0.037 Tw T* (\022\030\024\r\024\023\024\021\036\030\017 \017)Tj /Span<>> BDC ( )Tj EMC (\023\024\f\035\036\007\031\033\013\026\016 \r)Tj /Span<>> BDC ( )Tj EMC (\022\017\001\036\004\027\017\022\036 \021\030\026\027\f\235\024\030)Tj 0 Tw (-)Tj 0.163 Tw T* [(\n\026\006\017\016 \002\036\035\022\024\r )0.5(\022\030\024\r\017 \r)]TJ /Span<>> BDC ( )Tj EMC 9.926 0 Td [(\023\030\024\007\031\022\021\t )0.5(\026\024\021\017\f\021\024\020\024 \024\002\n\036\027\026 )]TJ 0.045 Tw -9.926 -1.218 Td [(\030\026\f\f\n\026\021\030\017\r\026\033\021\f\016 )0.6(\r)]TJ /Span<>> BDC ( )Tj EMC 8.203 0 Td [(\022\026\004\036\f\021\r\036 )0.5(\024\f\027\024\r\027\t\b )0.6(\023\030\017\004\017\027 )0.6(\023\024\r\t)]TJ 0 Tw (-)Tj 0.094 Tw -8.203 -1.218 Td (\001\036\027\017\016 \031\030\024\r\027\016 \n\024\004\036\r\017\027\t \022\ \030\024\r\017 \031)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\034\027\t\b \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\r\036\030\b)Tj 0 Tw (-)Tj 0.255 Tw T* (\027\017\b \020\026\f\021\030\024\017\027\021\036\f\021\017\027\026\035\034\ \027\t\b \022\030\024\r\024\021\036\004\036\027\017\016\b. \211\030\024\r\ \036\027\034 )Tj 0.623 Tw T* [(\n\024\004\036\r\017\027\t )0.5(\023\030\017)]TJ /Span<>> BDC ( )Tj EMC 7.359 0 Td [(\020\026\f\021\030\024\017\027\021\036\f\021\017\027\026\035\034\027\t\b\ )0.7(\022\030\024\r\024\021\036\004\036)]TJ 0 Tw (-)Tj 0.165 Tw -7.359 -1.218 Td (\027\017\016\b \002\024\035\036\036 21)Tj /Span<>> BDC ( )Tj EMC (\n\n\024\035\034/\035 \031\022\026\t\r\026\036\021 \027\026)Tj /Span<>> BDC ( )Tj EMC (\022\030\024\r\024\021\036\004\036\027\017\036 )Tj 0.398 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\r\036\030\b\027\017\b \024\021\007\036\035\024\r \032\036\035\031\007\024\ \004\027\024-\022\017\001\036\004\027\024\020\024 \021\030\026\022\021\026\ )Tj 0.171 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\004\031\r\f\021\r\017\021\036\035\034\027\024\f\021\034\033 36,4% \017)Tj /Span<>> BDC ( )Tj EMC (\f\023\036\006\017\235\017\004\027\024\f\021\034\033 93% )Tj 0.102 Tw T* ([14]. \224\024\024\021\027\024\001\036\027\017\036 \023\024\022\026\026\ \021\036\035\036\005 \n\024\004\036\r\017\027\t \017)Tj /Span<>> BDC ( )Tj EMC (\022\030\036\026\021\017)Tj 0 Tw (-)Tj 0.106 Tw T* (\027\017\027\026, \030\026\r\027\024\036 30 \017)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\036\036, \017\n\036\036\021 \f\023\036\006\017\235\017\004\027\ \024\f\021\034 98% )Tj 0.052 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\004\031\r\f\021\r\017\021\036\035\034\027\024\f\021\034 68,8% \007\035\016\ \r\t\016\r\035\036\027\017\016 \022\030\024\r\024\021\036\004\036)Tj 0 Tw (-)Tj -0.037 Tw T* (\027\017\005 \017)Tj /Span<>> BDC ( )Tj EMC (\r\036\030\b\027\017\b \024\021\007\036\035\024\r \032\036\035\031\007\024\ \004\027\024-\022\017\001\036\004\027\024\020\024 \021\030\026\022\021\026\ )Tj 0 Tw T* ([13].)Tj 0.399 Tw T* (\215\036\030\r\024\027\026\004\026\035\034\027\024\036 \022\035\017\027\017\ \004\036\f\022\024\036 \024\002\f\035\036\007\024\r\026\027\017\036 \002\ \024\035\034)Tj 0 Tw (-)Tj 0.216 Tw T* (\027\t\b \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\023\024\007\024\030\036\027\017\017 \027\026)Tj /Span<>> BDC ( )Tj EMC (\212\230\025 \007\024\035\032\027\024 \002\t\021\034 \027\026\023\030\026\ \r)Tj 0 Tw (-)Tj 0.51 Tw T* (\035\036\027\024 \027\026)Tj /Span<>> BDC ( )Tj EMC (\024\006\036\027\022\031 \032\017\027\036\027\027\024 \r\026\032\027\t\b\ \023\024\022\026\026\021\036\035\036\005, )Tj 0.154 Tw T* (\r\t\016\r\035\036\027\017\036 \f\024\023\031\021\f\021\r\031\033\013\017\ \b \026\002\024\035\036\r\026\027\017\005 \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\017\027\017\n\026)Tj 0 Tw (-)Tj 0.458 Tw T* [(\036\n\t\b )0.5(\n\036\007\017\022\026\n\036\027\021\024\r, )0.6(\035\026\002\024\030\026\021\024\030\027\024\036 )0.6(\024\002\f\035\036\007\024\r\026\027\017\036. )]TJ 0.086 Tw T* (\210\002\016\026\021\036\035\034\027\t \023\026\035\034\023\026\006\017\ \016 \032\017\r\024\021\026 \017)Tj /Span<>> BDC ( )Tj EMC (\030\036\022\021\026\035\034\027\024\036 \017\f\f\035\036)Tj 0 Tw (-)Tj 0.179 Tw T* (\007\024\r\026\027\017\036. \224\035\036\007\031\036\021 \017\n\036\021\034\ \r)Tj /Span<>> BDC ( )Tj EMC (\r\017\007\031, \004\021\024 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\024\021\f\031\021\f\021\r\017\017 )Tj 0.207 Tw T* (\220\027\007\024\f\022\024\023\017\004\036\f\022\017\b \023\030\017\027\ \026\022\024\r \r\024\n\024\032\027\024\020\024 \017\f\021\024\004\027\017\ \022\026 )Tj -0.029 Tw T* (\022\030\024\r\024\021\036\004\036\027\017\016, \026\035\020\024\030\017\ \021\n \024\002\f\035\036\007\024\r\026\027\017\016 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\024\f\021\030\t\b \020\026)Tj 0 Tw (-)Tj 0.114 Tw T* (\f\021\030\024\017\027\021\036\f\021\017\027\026\035\034\027\t\b \022\030\ \024\r\024\021\036\004\036\027\017\016\b \n\024\032\036\021 \r\022\035\033\ \004\026\021\034 )Tj 0.098 Tw T* (\022\026\023\f\031\035\034\027\031\033 \220\027\007\024\f\022\024\023\017\ \033 \021\024\027\022\024\005 \022\017\001\022\017 \(\031 \020\036\n\024\ \007\017\027\026)Tj 0 Tw (-)Tj -0.025 Tw T* (\n\017\004\036\f\022\017 \f\021\026\002\017\035\034\027\t\b \023\026\006\ \017\036\027\021\024\r\) \017\035\017 \f\036\035\036\022\021\017\r\027\031\ \033 \026\027)Tj 0 Tw (-)Tj 0.065 Tw T* (\020\017\024\020\030\026\235\017\033 \(\031 \027\036\f\021\026\002\017\035\ \034\027\t\b \023\026\006\017\036\027\021\024\r\) [12,13]. \212\035\016 \ )Tj 0.273 Tw T* [(\007\017\026\020\027\024\f\021\017\022\017 \212\230\025 \017\f\023\024\035\ \034\031\033\021\f\016 \030\026\035\017\004\027\t\036 )0.5(\017\027\f\021\030\031)]TJ 0 Tw (-)Tj 0.102 Tw T* (\n\036\027\021\026\035\034\027\t\036 \n\036\021\024\007\t \024\002\f\035\ \036\007\024\r\026\027\017\016)Tj /Span<>> BDC ( )Tj EMC (\227 \022\024\035\024\027\024\f\022\024\023\017\016, )Tj -0.044 Tw T* [(\022\024\n\023\034\033\021\036\030\027\026\016 )0.6(\021\024\n\024\020\030\026\235\017\016, )0.5(\021\030\026\027\f\026\002\007\024\n\017\027\026\035\034\027\024\036 )0.6(\211\003\236, )]TJ 0 Tw T* (\026\027\020\017\024\020\030\026\235\017\016, \f\006\017\027\021\017\020\ \030\026\235\017\016 [12,15,16,17,18].)Tj /T1_3 1 Tf 0 -2.436 TD (\222\b\240\002\217\220\002\212\t\201\r\217\220\t\r \214\r\003\002\240\t\220\ \t \240\t\004\n\b\002\217\003\t\220\t \031\020\021)Tj /T1_1 1 Tf 0.44 Tw 0 -1.218 TD (\200 \027\026\f\021\024\016\013\036\036 \r\030\036\n\016 \022\024\035\024\ \027\024\f\022\024\023\017\016 \030\036\022\024\n\036\027\007\031\036\021\ \f\016 )Tj 0.067 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\022\026\004\036\f\021\r\036 \024\f\027\024\r\027\024\020\024 \n\036\021\ \024\007\026 \007\017\026\020\027\024\f\021\017\022\017 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\023\024\007\024)Tj 0 Tw (-)Tj 0.267 Tw T* [(\030\036\027\017\017 )0.6(\027\026)]TJ /Span<>> BDC ( )Tj EMC 4.916 0 Td [(\212\230\025 )0.5([12,18]. )0.5(\215\030\024\020\027\024\f\021\017\004\036\f\022\017 )0.5(\002\035\026\020\024\023\030\017)]TJ 0 Tw (-)Tj 0.369 Tw -4.916 -1.218 Td (\016\021\027\t\n\017 \235\026\022\021\024\030\026\n\017, \023\024\r\t\001\ \026\033\013\017\n\017 \220\235\235\036\022\021\017\r\027\024\f\021\034 \ )Tj 0.445 Tw T* [(\220\027\007\024\f\022\024\023\017\004\036\f\022\024\005 )0.6(\007\017\026\020\027\024\f\021\017\022\017 )0.6(\023\030\017)]TJ /Span<>> BDC ( )Tj EMC 15.944 0 Td (\022\030\024\r\024\021\036\004\036\027\017\016\b )Tj 0.402 Tw -15.944 -1.218 Td (\017)Tj /Span<>> BDC ( )Tj EMC (\027\017\032\027\017\b \024\021\007\036\035\024\r \032\036\035\031\007\024\ \004\027\024-\022\017\001\036\004\027\024\020\024 \021\030\026\022\021\026\ , )Tj 0.272 Tw T* (\016\r\035\016\033\021\f\016 \024\023\t\021 \220\027\007\024\f\022\024\023\ \017\f\021\026 \(\002\024\035\036\036 1000 \022\024\035\024\027\024)Tj 0 Tw (-)Tj 0.529 Tw T* (\f\022\024\023\017\005\), \017\f\023\024\035\034\024\r\026\027\017\036 \ \r\024 \r\030\036\n\016 \022\024\035\024\027\024\f\022\024\023\017\017 )Tj 0.318 Tw T* [(\220\027\007\024\f\022\024\023\017\004\036\f\022\024\020\024 \022\024\035\ \023\026\004\022\026 end)-16(o)-16(cap \017)]TJ /Span<>> BDC ( )Tj EMC (\r\024\007\024\f\021\030\031\005)Tj 0 Tw (-)Tj 0.129 Tw T* (\027\024\020\024 \017\030\030\017\020\026\021\024\030\026 [12,19,20]. \224\ \004\017\021\026\036\021\f\016 \006\036\035\036\f\024\024\002\030\026)Tj 0 Tw (-)Tj 0.248 Tw T* (\027\t\n \r\024 \r\030\036\n\016 \r\t\023\024\035\027\036\027\017\016 \022\ \024\035\024\027\024\f\022\024\023\017\017 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\212\230\025 )Tj ET q 42.52 100.97 221.102 164.584 re W n q /GS0 gs 221.1023475 0 0 164.6864437 42.5196833 100.8678367 cm /Im0 Do Q Q BT 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0 Tw 9 0 0 9 42.5197 90.1701 Tm (\022\t\217\210\b\002\220 1.)Tj 0 0 0 1 k /GS1 gs /T1_4 1 Tf ( \210\027\034\021-\024\002\016\006\037 PRISMA \f\034\022\024\021\037 \027\ \022\035\016\033\037\035\023\033\032)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0 -1.2 TD [(F)-16(igure 1)47.1(.)]TJ 0 0 0 1 k /GS1 gs /T1_4 1 Tf [( P)66(RISMA f)-21.9(low char)-40(t for literature search)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\206)10(\002\036\033 \035\030\032\003\033)30(\n)42(\032)-21(\230\033\241)]TJ 57.136 0 Td (REVIEW)Tj /T1_5 1 Tf 25 0 0 25 504.6522 56.0378 Tm (211)Tj ET endstream endobj 111 0 obj <>stream AdobedC     '$''''$25552;;;;;;;;;;: X  v!61As"Ur#2QSTVa$q %&'()*345789:BCDEFGHIJRWXYZbcdefghijtuvwxyz?UJ!S4ۏMϙ)婴$I( fg1'hǔCRvjI yI0y$1'hǔCRvjI yI0y$1'hǔCRvjI yI0y$1'hǔCRvjI yI0y$1'hǔCRvjI yI0y$1'hǔCRvjI yI0y$1'hǔF+&ćQabm)sZK*Q-+m-QE+mmENPˮǧ*{*oR[Q!Fj223+*oVKDuĴK4,2Cw#I'wJCL $GC 7(#<&k,$ju5(RdmR 6NJbXVM~juHCdқ+qz,FDEnzR;hC3*ۺy關2WdDGl>%FQSTq>jJmǡIbQ$܏@&$QFmͣV4ZMDDe0bl&@ҽ:ЇI)*#Jer2=FC%",$%afS[HطŸ8]7MdkYiÛ"q4Xy'')nKj8Sc"4[άII"35mFW-"N7siHuIYTWJgr"+NR,Rɡ.L% ZRQ{6V=Ӥ{łT:0HeKS4{go) d:kd8&hQX򓓱e$?!kuxQaZJd$xx)MHjNo:Vq%NJFݶt]J`Iܗ{{tsCZVl\SS_W$h5德*K,YqJ̌aR('L3Ij^}Ƨ1Kf]˺#22)ELt-.=_~vg}ۏ&fE%%qiJbqZV2+_lb|X&J%A1S]NGuXbw4|aLh&[qfdJRQ}]ݬ[*s8a1֧Z&Mr-:wOtu^NR>it'|w?SI֓6Trq'/7\VSWQ" lCq^8xtZTwҒ}bM2!niICq)2d4R"m3cBb,}N RZJYF;62D< aBuǒ6 Su0bl&@ӽ:VjU86jJ&k2[AvB)z#dT$̤o)x3-[=ܢN9l= /Iym @dvT9mlj5%3o-5W^92uv;$(in$k”49FNk6]y"CoќJAң;嶈f3 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D)-30.3(i)-5.1(a)-10.8(g)-8.8(n)-11.9(o)-15.8(s)-29.3(t)-46.2(i)-5(c)-32.2(s o)-12.1(f)]TJ /Span<>> BDC ( )Tj EMC [(d)-15.8(i)-14.5(v)-18.7(e)-12.1(r)-59.7(t)-46.2(i)-4.9(c)-12.2(u)-8.4(l)-37.7(a)-10.2(r c)-6.5(o)-15.6(l)-20.9(o)-9.2(n)-14(i)-5(c b)-18.2(l)-23.7(e)-25.2(e)-21(d)-15.8(i)-3.2(n)-11.9(g \()39.2(r)-19.1(e)-15.8(v)-51.8(i)-11(e)-12.5(w)19.6(\))10.4(. )]TJ /T1_0 1 Tf 0.033 Tc -0.033 Tw [(K)13.9(ol)3.7(op)2.4(r)3.1(o)3.4(k)-19.2(t)2.3(ol)3.6(o)-3.3(g)-13.2(i)6.7(a)5.9(.)]TJ /T1_2 1 Tf 0 Tc 0 Tw 50.233 0 Td ( )Tj 0.023 Tc 0.024 Tw -56.693 -1.2 Td [(2)-8.9(0)-3.8(2)-1.4(5)23.3(;)9.8(2)8.8(4)-13.5(\()40.1(4)30.3(\))14.5(:)2.3(2)-8.9(0)-15.4(9)-22.6(\226)11.7(21)24.2(7)80.1(. \()-0.9(i)-3.2(n R)-6.5(u)-21.9(s)-22.3(s)-15.5(.)43.2(\))10.4(. )0.5(h)-17.3(t)-49.3(t)-29.4(p)-18.7(s)-8(:)1.9(/)84.7(/)36.4(d)-11.1(o)-12.5(i.)2.7(o)-11.8(r)-16.7(g)-22.8(/)11.2(1)14(0)6.5(.)-5.6(3)7.9(3)-15.9(8)1.3(7)4.6(8/)7.9(2)-8.9(0)9.3(7)-1.9(3)-13.3(-)41.2(7)10.7(55)-9(6)-26.7(-)9.8(2)-8.9(0)-3.9(2)-1.4(5)-23.5(-)9.7(2)8.8(4)-28.5(-)-30.3(4)-28.5(-)9.7(2)-8.9(0)-15.4(9)-23.6(-)9.7(21)24.2(7)]TJ /T1_1 1 Tf 0.01 Tc 0.076 Tw 0.005 -2.617 Td [(\021\024\027\030\026)5( \024\033\023)5( \t\030\027\030\t\032\026\037\032:)]TJ /T1_0 1 Tf 0 Tc 0.081 Tw 10.693 0 Td ( \212\034\b\034\033\021\034\036\024\021\022\004 \214\037\033\021 \205\020\ \037\035\034\027\003\016\036\022\005, \210\215\255 \240 \253\034\033\034\ \020\016\201\024\021\037\030 \034\025\027\037\024\035\020\037\030 \021\027\ \022\020\022\005\016\024\021\037\030 \025\034\027\003\020\022\007\037 \230\ 1\273, \214\034\024\021\034\036\024\021\022\004 )Tj 0.023 Tw -10.698 -1.2 Td (\f\033\034\024\f\016\021\035, \b.)Tj /Span<>> BDC ( )Tj EMC (151, \034\033\034\020\016\201, 394066, \213\034\024\024\022\030; \035\016\ \027.)Tj /Span<>> BDC ( )Tj EMC (+7 \(4732\)57-97-06; \016-mail: vgmi_30@mail.ru.)Tj /T1_1 1 Tf 0.01 Tc 0.019 Tw 0.005 -1.2 Td [(ADDRESS)5( F)13(OR)5( C)19(ORRESPONDEN)23(CE:)]TJ /T1_0 1 Tf 0 Tc 0.024 Tw 14.052 0 Td [( Mark A. 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gs /T1_3 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 70.936 383.8459 Tm (\023\023\034\226\034\022\031\034)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf 0.002 Tc 1.389 Tw 10 0 0 10 70.8661 359.4899 Tm [(\240\036\035\031\007\024\004\027\024-\022\017\001\036\004\027\t\036 \022\ \030\024\r\024\021\036\004\036\027\017\016 \016\r\035\016\033\021\f\016)2( )]TJ 0.55 Tw 0 -1.218 TD (\024\007\027\024\005 \017)Tj /Span<>> BDC ( )Tj EMC [(\030\026\f\023\030\024\f\021\030\026\027\036\027\027\t\b \023\030\017\004\ \017\027 \024\002\030\026\013\036\027\017\005)2( )]TJ 0.252 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\024\021\007\036\035\036\027\017\016 \027\036\024\021\035\024\032\027\024\ \005 \023\024\n\024\013\017 \017)Tj /Span<>> BDC ( )Tj EMC (\021\024\035\034\022\024 \r)Tj /Span<>> BDC ( )Tj EMC [(\224\221\202)2( )]TJ 0.089 Tw T* [(\036\032\036\020\024\007\027\024 )0.5(\r\t\016\r\035\016\036\021\f\016 )0.5(\024\022\024\035\024 800000 \023\026\006\017\036\027\021\024\r \f)]TJ /Span<>> BDC ( )Tj EMC (\020\026)Tj 0 Tc 0 Tw (-)Tj 0.002 Tc 0.281 Tw T* (\f\021\030\024\017\027\021\036\f\021\017\027\026\035\034\027\t\n\017 \022\ \030\024\r\024\021\036\004\036\027\017\016\n\017, \017)Tj /Span<>> BDC ( )Tj EMC [(\022\024\021\024\030\t\b)2( )]TJ 0.099 Tw T* (\024\022\024\035\024 \023\024\035\024\r\017\027\t \027\031\032\007\026\033\ \021\f\016 \r)Tj /Span<>> BDC ( )Tj EMC [(\020\024\f\023\017\021\026\035\017\026\006\017\017 [1,2].)2( )]TJ 0.556 Tw T* (\200)Tj /Span<>> BDC ( )Tj EMC [(\f\021\030\031\022\021\031\030\036 \020\026\f\021\030\024\017\027\021\036\ \f\021\017\027\026\035\034\027\t\b \022\030\024\r\024\021\036\004\036\027\ \017\005)2( )]TJ 0.161 Tw T* [(\004\026\f\021\024\021\026 )0.5(\007\017\r\036\030\021\017\022\031\035\016\030\027\t\b )0.5(\021\024\035\f\021\024\022\017\001\036\004\027\t\b )0.5(\022\030\024\r\024\021\036)]TJ 0 Tc 0 Tw (-)Tj 0.002 Tc 0.02 Tw T* (\004\036\027\017\005 \(\212\230\025\) \026)Tj /Span<>> BDC ( )Tj EMC (\023\024\f\035\036\007\027\017\036 20 \035\036\021 \031\r\036\035\017\004\ \017\035\026\f\034 \f)Tj /Span<>> BDC ( )Tj EMC [(5,9%)2( )]TJ -0.006 Tw T* (\007\024)Tj /Span<>> BDC ( )Tj EMC (23,0% [3]. \230\024\035\034\022\024 \026)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\017\024\007 \f)Tj /Span<>> BDC ( )Tj EMC (2012 \023\024)Tj /Span<>> BDC ( )Tj EMC (2019 \020\020. \023\024)Tj 0 Tc 0 Tw (-)Tj 0.002 Tc 0.206 Tw T* (\022\026\026\021\036\035\017 \020\024\f\023\017\021\026\035\017\026\006\ \017\017 \002\024\035\034\027\t\b \f)Tj /Span<>> BDC ( )Tj EMC (\212\230\025 \r)Tj /Span<>> BDC ( )Tj EMC [(\233\023\024\027\017\017)2( )]TJ 0.181 Tw T* (\002\024\035\036\036 \004\036\n \031\007\r\024\017\035\017\f\034, \031\r\ \036\035\017\004\017\r\001\017\f\034 \f)Tj /Span<>> BDC ( )Tj EMC (15,1 \007\024)Tj /Span<>> BDC ( )Tj EMC [(34,0)2( )]TJ 0.188 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC 1.4 0 Td (100000)Tj /Span<>> BDC ( )Tj EMC 3.435 0 Td [(\027\026\f\036\035\036\027\017\016. )0.5(\217\036\031\035\034\021\026\021\t )0.5(\007\026\027\027\t\b )0.5(\017\f\f\035\036\007\024)]TJ 0 Tc 0 Tw (-)Tj 0.002 Tc 0.125 Tw -4.835 -1.218 Td (\r\026\027\017\005 \023\024\007\004\036\030\022\017\r\026\033\021 \022\026\ \030\007\017\027\026\035\034\027\t\005 \f\007\r\017\020 \r)Tj /Span<>> BDC ( )Tj EMC [(\004\026\f\021\024\021\036)2( )]TJ 0.276 Tw T* (\020\024\f\023\017\021\026\035\017\026\006\017\005 \002\024\035\034\027\ \t\b \f)Tj /Span<>> BDC ( )Tj EMC [(\020\026\f\021\030\024\017\027\021\036\f\021\017\027\026\035\034\027\t\n\ \017)2( )]TJ 0.313 Tw T* (\022\030\024\r\024\021\036\004\036\027\017\016\n\017 \f)Tj /Span<>> BDC ( )Tj EMC (\r\036\030\b\027\017\b \024\021\007\036\035\024\r \240\025\230 \027\026)Tj /Span<>> BDC ( )Tj EMC (\027\017\032)Tj 0 Tc 0 Tw (-)Tj 0.002 Tc 0.174 Tw T* (\027\017\036 \024\021\007\036\035\t, \004\021\024 \031\022\026\t\r\026\036\ \021 \027\026)Tj /Span<>> BDC ( )Tj EMC (\027\036\024\002\b\024\007\017\n\024\f\021\034 \f\024\024\021)Tj 0 Tc 0 Tw (-)Tj 0.002 Tc 0.354 Tw T* [(\r\036\021\f\021\r\031\033\013\036\020\024 \017\n\036\027\036\027\017\016\ )0.5(\022\035\017\027\017\004\036\f\022\024\005 )0.5(\027\026\023\030\026\r\035\036\027)]TJ 0 Tc 0 Tw (-)Tj 0.002 Tc 0.234 Tw T* (\027\024\f\021\017 \017)Tj /Span<>> BDC ( )Tj EMC [(\030\026\f\023\030\036\007\036\035\036\027\017\016 \030\036\f\031\030\f\024\ \r \007\030\026\r\024\024\b\030\026\027\036\027\017\016)2( )]TJ 0.35 Tw T* ([4]. \025)Tj /Span<>> BDC ( )Tj EMC (\026\002\024\035\036\r\026\027\017\016\n \017)Tj /Span<>> BDC ( )Tj EMC [(\f\024\f\021\024\016\027\017\016\n, \023\024\r\t\001\026\033\013\017\n)1.9( )]TJ 0.493 Tw T* [(\030\017\f\022\017 \030\026\r\017\021\017\016 \212\230\025, \024\021\027\ \024\f\016\021\f\016 \020\017\023\036\030\021\024\027\017\004\036\f\022\026\ \016)2( )]TJ 0.637 Tw T* [(\002\024\035\036\027\034, \f\026\b\026\030\027\t\005 \007\017\026\002\036\ \021, \f\036\030\007\036\004\027\024-\f\024\f\031\007\017\f\021\t\036)2( )]TJ 0.223 Tw T* [(\026\002\024\035\036\r\026\027\017\016, \r\t\f\024\022\017\005 \017\027\ \007\036\022\f \n\026\f\f\t \021\036\035\026, \022\031\030\036\027\017\036\ )1.9( )]TJ 0.03 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC [(\031\023\024\021\030\036\002\035\036\027\017\036 \026\035\022\024\020\024\ \035\016 [5,6]. \215\030\017\036\n \027\036\f\021\036\030\024\017\007\027\ \t\b)2( )]TJ -0.005 Tw 23.244 30.445 Td [(\023\030\024\021\017\r\024\r\024\f\023\026\035\017\021\036\035\034\027\t\ \b )0.5(\023\030\036\023\026\030\026\021\024\r )0.5(\023\024\r\t\001\026\036\021 )0.5(\030\017\f\022\017)2( )]TJ -0.016 Tw T* (\021\024\035\f\021\024\022\017\001\036\004\027\t\b \022\030\024\r\024\021\ \036\004\036\027\017\005 \017-\026 \r\024\n\024\032\027\024\020\024 \023\ \024)Tj 0 Tc 0 Tw (-)Tj 0.002 Tc 0.037 Tw T* (\r\030\036\032\007\036\027\017\016 \f\035\017\017\f\021\024\005 \024\002\ \024\035\024\004\022\017 \007\017\r\036\030\021\017\022\031\035\026 \017\ )Tj /Span<>> BDC ( )Tj EMC (\016\r\035\016)Tj 0 Tc 0 Tw (-)Tj 0.002 Tc 0.211 Tw T* [(\036\021\f\016 \027\026\004\017\n\t\n \235\026\022\021\024\030\024\n \023\ \030\017\004\017\027 \007\017\r\036\030\021\017\022\031\035\016\030\027\t\ \b)2( )]TJ 0.178 Tw T* (\022\030\024\r\024\021\036\004\036\027\017\005 \031)Tj /Span<>> BDC ( )Tj EMC [(\023\026\006\017\036\027\021\024\r \f\021\026\030\001\036 65 \035\036\021\ [7]. \217\024\f\021)2.1( )]TJ 0.312 Tw T* (\004\017\f\035\026 \021\016\032\201\035\t\b \212\230\025 \031)Tj /Span<>> BDC ( )Tj EMC [(\023\024\032\017\035\t\b \023\026\006\017\036\027\021\024\r \f\r\016\026\ \027)2( )]TJ 0.004 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\030\026\035\017\004\027\t\n\017 \235\026\022\021\024\030\026\n\017: \017\ \n\036\027\036\027\017\036 \032\017\027\036\027\027\024 \r\026\032)Tj 0 Tc 0 Tw (-)Tj 0.002 Tc -0.014 Tw T* (\027\t\b \023\024\022\026\026\021\036\035\036\005, \020\017\023\024\026\ \035\034\002\031\n\017\027\036\n\017\016, \027\026\035\017\004\017\036 \007\ \017\r\036\030)Tj 0 Tc 0 Tw (-)Tj 0.002 Tc 0.114 Tw T* (\021\017\022\031\035\024\r \r \023\030\026\r\024\005 \017)Tj /Span<>> BDC ( )Tj EMC [(\035\036\r\024\005 \023\024\035\024\r\017\027\036 \021\024\035\f\021\024\ \005 \022\017\001\022\017,)2( )]TJ -0.002 Tw T* (\023\030\017\036\n \r\026\030\235\026\030\017\027\026, \020\017\023\036\030\ \021\036\027\017\016, \r\t\f\024\022\017\005 \017\027\007\036\022\f \n\026\ \f)Tj 0 Tc 0 Tw (-)Tj 0.002 Tc T* (\f\t \021\036\035\026 [8,9].)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 303.3769 225.5319 Tm (\017\034\r\237)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf 0 Tc 0.209 Tw 10 0 0 10 303.3071 201.1759 Tm (\215\030\024\r\036\f\021\017 \026\027\026\035\017 \024\023\031\002\035\017\ \022\024\r\026\027\027\t\b \007\026\027\027\t\b \023\024)Tj /Span<>> BDC ( )Tj EMC (\007\017\026\020)Tj 0 Tw (-)Tj 0.413 Tw T* (\027\024\f\021\017\022\036 \007\017\r\036\030\021\017\022\031\035\016\030\ \027\t\b \021\024\035\f\021\024\022\017\001\036\004\027\t\b \022\030\024\ \r\024)Tj 0 Tw (-)Tj 0.326 Tw T* (\021\036\004\036\027\017\005 \017)Tj /Span<>> BDC ( )Tj EMC (\024\002\024\f\027\024\r\026\021\034 \r\t\002\024\030 \220\235\235\036\022\ \021\017\r\027\024\005 \021\026\022\021\017)Tj 0 Tw (-)Tj 0.307 Tw 0 -1.218 TD (\022\017 \022\035\017\027\017\004\036\f\022\024\020\024 \024\002\f\035\036\ \007\024\r\026\027\017\016 \002\024\035\034\027\t\b \f)Tj /Span<>> BDC ( )Tj EMC (\007\026\027\027\024\005 )Tj 0 Tw 0 -1.218 TD (\023\026\021\024\035\024\020\017\036\005.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0.01 Tc 0.018 Tw 14 0 0 14 303.3769 115.9299 Tm [(\240)21(\026)45(\024\034\033\031\026)-10(\r\232)5( \031)5(\016)-18.3(\240\034)-31(\024)35(\037\226\232)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf 0 Tc 0.052 Tw 10 0 0 10 303.3071 91.5739 Tm [(\212\035\016 )0.5(\023\024\017\f\022\026 \017)]TJ /Span<>> BDC ( )Tj EMC [(\026\027\026\035\017\026 )0.5(\017\027\235\024\030\n\026\006\017\017 )0.5(\002\t\035 \024\f\031\013\036\f\021\r\035\036\027 )]TJ 0.133 Tw 0 -1.218 TD (\f\017\f\021\036\n\026\021\017\004\036\f\022\017\005 \023\024\017\f\022 \ \035\017\021\036\030\026\021\031\030\t \023\024)Tj /Span<>> BDC ( )Tj EMC (\220\035\036\022\021\030\024\027\027\t\n )Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 0 Tw 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\206)10(\002\036\033 \035\030\032\003\033)30(\n)42(\032)-21(\230\033\241)]TJ 57.136 0 Td (REVIEW)Tj -57.136 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 2)69(4, \023\0224, 202)23(5)]TJ 43.013 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 2)69(4, \023\0224, 202)23(5)]TJ /T1_5 1 Tf 25 0 0 25 20.7653 56.0378 Tm (210)Tj ET endstream endobj 296 0 obj <> endobj 301 0 obj <> endobj 302 0 obj <> endobj 303 0 obj <>stream H\ˊ0E --Yecե)<ϩ i/NccpgėyzUw?,6uaꇫz9?YjT]@_N-\}_qο?_cPF~kʴ.>TSq \Z5׈_s/J%%$u%ѧ\|: 2T Y@m}: #^*9{ G^=%OgAJpnY@&c-gr~RL'CpML}As#W;q!|ފ}Tq 15z endstream endobj 304 0 obj <>stream HU T#A.Y J`V% >DM $("jP}{E^BԈO4XIjj46bnn8朙;Hzeq^N^l ka%թӬ+RgVWV 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CU/KL ;^W_D_oH#x븘x,hb~:IBp0\Af6/2s'D?5IZ:kt}Dh?zH)}+N0gf2Rí!$ssU49') c<:'__Rs uh!9e ?J't*fC܍z<˭Nٕ2?:&Ƨd֢:CGA4EH֒=%O@5~ڑ׈Fx& Jw(bbp e9 }Czb+W4 qڹ;旰~7s'~Ce\ˈH^c![aHю敢uWyW TGu[\r*~%UWj\Y`m_N>3 %hSC1%&(*-Xqϯ6x`W29w%#-[tT%JXiKfD~w{%3ƸÁGR%h0~3ENKk 6Z[ \k;aS]I#栝y&~7Yb#傊W:v9ld9}Tv0&,.ӫ'%\B!ɃQ0\>1iq*^?f/G ̹}kt׊;_r3[I pu"ZzܣdfF ?vMN|k%ʨ}j5 QR} H4JNG QRRI] ave&w[kUl6nfs˽=2F@aju 0a5ڪ򐻌p`M5a) y0 N M: EӌkËBPm!$>o$H1}\'9^8 ,\h4C.d=:u7g2>wkBH9)v~%ʨH|Ӿ_;4!?QWw-z2< zm`nHN, *;6Ou Ze;,ȣz]OOYt׃d0(x+hnk/y6qt$=> %>:*JBܣh߶ 8}Lɚ]nz}#3ndT"QeC%tߛߙ}"2A&є:{mnHOr$qaPI597I{ch 4ovPoӑpW{ o[Ⱦ=[:|VU*F=1tHWdKIu4|b7MB(l2z#㈏]wVjy*Q3|h9tƻ큅VF)),5;jL$͉ gjP}X|`2g ͬMly܍Lk:c@cQz 8id^ X׻+¥ǩvmZ;ȉh75k<@lu(Jy52bM(!BJ5kQIc#LО$ %X67_Sã뗈_\Mq pTBup.zBMi2m`:hH܏u&[%~X\]jnpBK?'z Od$DCc8wQ掗8ލO&N E7K!$%%XIWm]^tF-$q"F9R_*M5.m,@)h>y^XHxJ*Z,. %L]Em^qw .AnR\߈q21qdj:)ڒ#{M`Ni~~^Ԣ{&zi5Ԩ!TY|\n0$FpaJ-kxŸYOn{EI:F%*@RdY!$]?V /Ba ),>a]VI#鴆XDQd |&;cѹԝm9sUd(U YT"[6SFk q\%KbLɂX/vM(:~ș}WkXˤmp5Kg1W&C`ǟ;Ao/]\)rF<5ۋH+ghs ڵՏZK+z>^U6%s4V NX0yTb~QZ/L͚֢ћ@cg̹}dF5eB> F-xQ8CRꓼ@Ȃ`jcF;V8 I;lhDPBPK^8yx :CT$ȄFdNVTp>dlyuE`RbWُ1X( ;{cȫ@'ѫ]]l]9_SBd-!U pWUt ^,!މRa rMϚm}Tc`'U&,//[~x}wإj*2ɮ۴oN,T7 fd :fvM.5wrW@iTH4v6W&-k#]8gIKf_~ jRյW- ,/}ڮj'vV~miNi`1ełGoUe+Fʃ'>nw@~9ٮI}[ XcW͛lumf3n;(}hbbFRsu|FmQbܭz4{.1$$\#ch}GOtx;㏊`B}]tqgM'j`$Ɠ? >Qwd֎6 }]r19q ͚7kĊ9){KttKNR}@r~ l{N+g^`hEjw3 m= Sڼcb$_՜Ms̹>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\240\021\001\202\215\025\b)-9.9(\026\021\017\001 \211\021\r\016\201\026\021\017\200\t\004\201\215\220 \026\ )11.1(\025\t\b)-10(\026)11(\025\017\021\020\016\f\215\220 )]TJ 0 -1 TD [(\017\201\025\r\025\026)11(\016\f\016\215\021\207 \(\025\235\213\025\201 \t\021\026)11(\016\201\001\026)-19.9(\200\201\220\))]TJ 39.93 1 Td [(Diagnostics of\022div)12.1(er)-20(ticular colonic bleeding \(r)31(e)11(vie)11(w\))]TJ ET 0 0 0 1 K 1 j 1 J [0 2.997]0 d /GS1 gs q 1 0 0 1 46.0167 263.1411 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 43.0197 263.1411 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q [0 2.997]0 d q 1 0 0 1 46.0167 235.5332 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 43.0197 235.5332 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q BT 0 0 0 1 k /T1_1 1 Tf 10 0 0 10 42.5197 724.8299 Tm (https://doi.org/10.33878/2073-7556-2025-24-4-209-217)Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 0.023 Tw 19 0 0 19 80.5428 695.3259 Tm [(\240\021\001\202\215\025\b)-9.9(\026\021\017\001 \211\021\r\016\201\026\021\017\200\t\004\201\215\220 \026\ )11(\025\t\b)-9.9(\026)11(\025\017\021\020\016\f\215\220 )]TJ 2.777 -1.105 Td [(\017\201\025\r\025\026)11(\016\f\016\215\021\207 \(\025\235\213\025\201 \t\021\026)11(\016\201\001\026)-19.9(\200\201\220\))]TJ 0 0 0 1 k /GS1 gs 0 Tw 14 0 0 14 42.5197 649.822 Tm [(\225\017)-10(\026)11(\025\r\022)-23.2(\006.\217.)]TJ 8.162 0 0 8.162 103.1568 654.484 Tm (1)Tj 0.023 Tw 14 0 0 14 107.7928 649.822 Tm [(, \203\016\211\025\201\025\r\022)-23.2(\n)-31(.\006.)]TJ 0 Tw 8.162 0 0 8.162 197.0496 654.484 Tm (2)Tj 0.023 Tw 14 0 0 14 201.6856 649.822 Tm [(, \005\025\211\025\201\017)10(\025\r\b\017\021\207\022)-23.2(\007.\n)-31(.)]TJ 0 Tw 8.162 0 0 8.162 324.6541 654.484 Tm (1)Tj 5.83 0 0 5.83 42.5197 635.4827 Tm (1)Tj 0.023 Tw 10 0 0 10 45.8311 632.1527 Tm [(\203\031\206)21(\036)20(\230 \006\036 \253\006\025\201\025\215\016\216\b\017\021\207 \202)10(\025\b\200\211\001\201\b)-10(\026\r\016\215\215\220\207 \024\016\211\021\212\021\215\b\017\021\207 \200\ \215\021\r\016\201\b\021\026)11(\016\026 \021\024.\022)-23.3(\217.\217.\022)-23.3(\206\200\201\211\016\215\017)10(\025\273 \007\021\215\213\211\201\001\r\001 )]TJ -0.331 -1.2 Td [(\033\025\b\b\021\021 \(\200\t.\022)-23.2(\013\026)-20(\200\211\016\215\f\016\b\017\001\004, \211.\022)-23.3(1)75(0, \202)62(.\022)-23.3(\006\025\201\025\215\016\216, 3)11(9)80(4036, \033\025\b\b\021\004\))]TJ 0 Tw ( )Tj 5.83 0 0 5.83 42.5197 611.4827 Tm (2)Tj 0.023 Tw 10 0 0 10 45.8311 608.1527 Tm [(\203\031\206)42(\230 \253\217\001\212\021\025\215\001\t\214\215\220\207 \024\016\211\021\ \212\021\215\b\017\021\207 \021\b\b)-10(\t\016\211\025\r\001\026)11.1(\016\t\214\b\017\021\207 \212\016\215\026\201 \021\201\200\201\202\021\021\ \021\024.\022)-23.3(\n)-31(.\006.\022)-23.3(\006\021\020\215\016\r\b\017)10(\025\202)10(\025\273 \007\021\215\213\211\201\001\r\001 )]TJ -0.331 -1.2 Td [(\033\025\b\b\021\021 \(\200\t.\022)-23.2(\206\025\t\214\020\001\004 \013\016\201\222\200)21(\025\r\b\017\001\004, \211.\022)-23.3(2)46(7)127(, \202)62(.\022)-23.2(\007\025\b\017\r\001, 1)212(1)138(7)35(99)35(7)127(, \033\025\b\b\021\004\))]TJ /T1_1 1 Tf -0.01 Tc -0.028 Tw 9 0 0 9 90.7087 577.6488 Tm (\221\204\231\232: \f\033\034\036\016\024\035\022 \037\020\037\027\022\031\ \034\f\023\025\027\022\021\034\036\037\020\020\032\002 \b\037\020\020\032\ \002 \f\034)Tj /Span<>> BDC ( )Tj EMC (\b\022\037\013\020\034\024\035\022\021\016 \b\022\036\016\033\035\022\021\ \023\027\030\033\020\032\002 \035\034\027\024\035\034\021\022\001\016\005\ \020\032\002 \021\033\034\036\034\035\016)Tj 0 Tc 0 Tw (-)Tj -0.01 Tc 0.013 Tw 0 -1.111 TD (\005\016\020\022\004 \022)Tj /Span<>> BDC ( )Tj EMC (\034\025\034\024\020\034\036\037\035\003 \036\032\025\034\033 \220\017\017\ \016\021\035\022\036\020\034\004 \035\037\021\035\022\021\022 \021\027\022\ \020\022\005\016\024\021\034\013\034 \034\025\024\027\016\b\034\036\037\020\ \022\030 \025\034\027\003\020\032\002 \024)Tj /Span<>> BDC ( )Tj EMC (\b\037\020\020\034\004 \f\037\035\034\027\034\013\022\016\004.)Tj 0 Tc 0.176 Tw T* (\214\205\202\204\213\200\205\231\233 \200)Tj /Span<>> BDC ( )Tj EMC (\214\204\202\240\n\233: \034\024\023\235\016\024\035\036\027\016\020 \024\ \022\024\035\016\006\037\035\022\005\016\024\021\022\004 \f\034\022\024\021\ \027\022\035\016\033\037\035\023\033\032 \f\034)Tj /Span<>> BDC ( )Tj EMC (\220\027\016\021\035\033\034\020\020\032\006 \025\037\031\037\006 \b\037\ \020)Tj 0 Tw (-)Tj 0.097 Tw T* (\020\032\002 eLibrary.ru, PubMed \022)Tj /Span<>> BDC ( )Tj EMC (Cochrane Library \031\037)Tj /Span<>> BDC ( )Tj EMC (\f\016\033\022\034\b \024)Tj /Span<>> BDC ( )Tj EMC (2005 \f\034)Tj /Span<>> BDC ( )Tj EMC (2025 \013\013. \n\027\030 \024\025\034\033\037 \034\f\023\025\027\022\021\ \034\036\037\020\020\032\002 \b\037\020\020\032\002 )Tj 0.112 Tw T* [(\022\024\f\034\027\003\031\034\036\037\027\022\024\003 )0.5(\f\034\022\024\021\034\036\032\016 )0.5(\031\037\f\033\034\024\032)]TJ /Span<>> BDC ( )Tj EMC 15.193 0 Td [(\227 colonic )0.5(bleeding OR )0.5(colonic diverticular )0.5(bleeding AND )0.5(colonoscopy AND )]TJ -0.019 Tw -15.193 -1.111 Td (contrast-enhanced computed tomography AND arteriography AND transabdomin\ al ultrasound AND technetium-99m-)Tj 0.112 Tw T* [(tagged )0.5(red blood )0.5(cell )0.5(scanning. \t\016\033\036\022\005\020\034 \025\032\027\034 )0.5(\020\037\004\b\016\020\034 )0.5(832 \f\023\025\027\022\021\037\007\022\022. )0.5(\t\034\024\027\016 \024\021\033\022\020\022\020\013\037 \022)]TJ /Span<>> BDC ( )Tj EMC [(\034\007\016\020\021\022 )0.5(\033\016\031\026\006\016 )]TJ 0.117 Tw 0 -1.111 TD (\024)Tj /Span<>> BDC ( )Tj EMC (\f\034\024\027\016\b\023\026\235\022\006 \022\031\023\005\016\020\022\016\ \006 \f\034\027\020\032\002 \035\016\021\024\035\034\036 \024\035\037\035\ \016\004 \025\032\027\034 \034\035\034\025\033\037\020\034 66 \024\035\037\ \035\016\004, \024\033\016\b\022 \020\022\002)Tj /Span<>> BDC ( )Tj EMC (\227 4 \006\016\035\037\037\020\037)Tj 0 Tw (-)Tj 0.054 Tw 0 -1.111 TD (\027\022\031\037, 5 \034\025\031\034\033\034\036, 34 \021\027\022\020\022\ \005\016\024\021\022\002 \022\024\024\027\016\b\034\036\037\020\022\030,\ 5 \021\027\022\020\022\005\016\024\021\022\002 \033\016\021\034\006\016\ \020\b\037\007\022\004. \n\037\020\020\037\030 \024\035\037\035\003\030 \ \f\034\b\013\034\035\034\036\027\016\020\037 )Tj 0.023 Tw 0 -1.111 TD (\036)Tj /Span<>> BDC ( )Tj EMC (\024\034\034\035\036\016\035\024\035\036\022\022 \024\034 \024\035\037\020\ \b\037\033\035\037\006\022 PRISMA.)Tj 0.035 Tw T* (\213\204\255\215\231\232\202\205\202\233: \031\037)Tj /Span<>> BDC ( )Tj EMC (\f\034\024\027\016\b\020\022\016 20 \027\016\035 \036)Tj /Span<>> BDC ( )Tj EMC (\024\035\033\023\021\035\023\033\016 \013\037\024\035\033\034\022\020\035\ \016\024\035\022\020\037\027\003\020\032\002 \021\033\034\036\034\035\016\ \005\016\020\022\004 \031\020\037\005\022\035\016\027\003\020\034 \023\036\ \016\027\022)Tj 0 Tw (-)Tj 0.054 Tw T* (\005\022\027\037\024\003 \005\037\024\035\034\035\037 \035\034\027\024\035\ \034\021\022\001\016\005\020\032\002 \b\022\036\016\033\035\022\021\023\027\ \030\033\020\032\002 \021\033\034\036\034\035\016\005\016\020\022\004. \ )Tj /Span<>> BDC ( )Tj EMC (\020\037\024\035\034\030\235\016\016 \036\033\016\006\030 \036)Tj /Span<>> BDC ( )Tj EMC (\021\037\005\016\024\035\036\016 \034\024\020\034\036)Tj 0 Tw (-)Tj 0.121 Tw T* (\020\034\013\034 \006\016\035\034\b\037 \b\022\037\013\020\034\024\035\022\ \021\022 \035\034\027\024\035\034\021\022\001\016\005\020\032\002 \b\022\ \036\016\033\035\022\021\023\027\030\033\020\032\002 \021\033\034\036\034\ \035\016\005\016\020\022\004 \033\016\021\034\006\016\020\b\023\016\035\024\ \030 \036\032\f\034\027\020\016\020\022\016 )Tj 0.087 Tw T* (\033\037\020\020\016\004 \021\034\027\034\020\034\024\021\034\f\022\022 \ \024)Tj /Span<>> BDC ( )Tj EMC (\022\024\f\034\027\003\031\034\036\037\020\022\016\006 \024\035\037\020\b\ \037\033\035\020\032\002 \033\037\024\035\036\034\033\034\036 \b\027\030\ \034\033\037\027\003\020\034\013\034 \027\037\036\037\201\037, \220\020\ \b\034\024\021\034\f\022\005\016\024\021\034\013\034 )Tj 0.231 Tw T* (\021\034\027\f\037\005\021\037 \022)Tj /Span<>> BDC ( )Tj EMC (\036\034\b\034\024\035\033\023\004\020\034\013\034 \022\033\033\022\013\037\ \035\034\033\037. \r\034\006\f\003\026\035\016\033\020\037\030 \035\034\006\ \034\013\033\037\017\022\030 \024)Tj /Span<>> BDC ( )Tj EMC (\021\034\020\035\033\037\024\035\020\032\006 \023\024\022\027\016\020\022\ \016\006 \006\034\201\016\035 )Tj -0.001 Tw T* (\025\032\035\003 \036\032\025\033\037\020\037 \020\037\005\037\027\003\020\ \032\006 \b\022\037\013\020\034\024\035\022\005\016\024\021\022\006 \006\ \016\035\034\b\034\006 \034\025\024\027\016\b\034\036\037\020\022\030 \036\ )Tj /Span<>> BDC ( )Tj EMC (\024\027\023\005\037\030\002, \021\034\013\b\037 \021\037\005\016\024\035\ \036\016\020\020\037\030 \220\021\024\035\033\016\020)Tj 0 Tw (-)Tj 0.005 Tw T* [(\020\037\030 \021\034\027\034\020\034\024\021\034\f\022\030 \020\016 \006\ \034\201\016\035 \025\032\035\003 \036\032\f\034\027\020\016\020\037, )0.5(\037)]TJ /Span<>> BDC ( )Tj EMC (\035\037\021\201\016 \f\033\022)Tj /Span<>> BDC ( )Tj EMC (\020\016\220\017\017\016\021\035\022\036\020\034\024\035\022 \220\020\b\034\ \024\021\034\f\022\005\016\024\021\034\013\034 \013\016\006\034\024\035\037\ \031\037, )Tj 0.062 Tw 0 -1.111 TD [(\021\034\013\b\037 \034\025\024\023\201\b\037\016\035\024\030 \036\034\031\ \006\034\201\020\034\016 \f\033\022\006\016\020\016\020\022\016 \035\033\ \037\020\024\021\037\035\016\035\016\033\020\034\004 )0.5(\037\033\035\016\033\022\037\027\003\020\034\004 \220\006\025\034\027\022\ \031\037\007\022\022 \022\027\022 \036\032\f\034\027\020\016\020\022\016\ )]TJ 0.163 Tw 0 -1.111 TD (\002\022\033\023\033\013\022\005\016\024\021\034\013\034 \036\006\016\001\ \037\035\016\027\003\024\035\036\037. \t\033\022\006\016\020\016\020\022\ \016 \024\016\027\016\021\035\022\036\020\034\004 \037\020\013\022\034\013\ \033\037\017\022\022 \034\f\033\037\036\b\037\020\034 \f\033\022)Tj /Span<>> BDC ( )Tj EMC (\f\033\034\b\034\027\201\037\026\235\016\006\024\030 )Tj 0.279 Tw T* (\006\037\024\024\022\036\020\034\006 \022\027\022 \b\027\022\035\016\027\ \003\020\034\006 \033\016\007\022\b\022\036\022\033\023\026\235\016\006 \ \b\022\036\016\033\035\022\021\023\027\030\033\020\034\006 \035\034\027\024\ \035\034\021\022\001\016\005\020\034\006 \021\033\034\036\034\035\016\005\ \016\020\022\022, \021\034\013\b\037 )Tj 0.023 Tw T* (\024)Tj /Span<>> BDC ( )Tj EMC (\f\034\006\034\235\003\026 \021\034\027\034\020\034\024\021\034\f\022\022\ \020\016 \023\b\037\016\035\024\030 \034\f\033\016\b\016\027\022\035\003\ \006\016\024\035\034 \021\033\034\036\034\035\016\005\016\020\022\030.)Tj 0.092 Tw T* (\255\205\r\231\234\211\204\217\200\204: \f\016\033\024\034\020\037\027\022\ \031\022\033\034\036\037\020\020\032\004 \036\032\025\034\033 \b\022\037\ \013\020\034\024\035\022\005\016\024\021\034\004 \f\033\034\013\033\037\006\ \006\032 \034\025\024\027\016\b\034\036\037\020\022\030 \f\033\022)Tj /Span<>> BDC ( )Tj EMC (\035\034\027\024\035\034\021\022\001\016\005)Tj 0 Tw (-)Tj 0.065 Tw T* (\020\032\002 \021\033\034\036\034\035\016\005\016\020\022\030\002 \b\034\ \027\201\016\020 \025\032\035\003 \034\024\020\034\036\037\020 \020\037)Tj /Span<>> BDC ( )Tj EMC (\034\025\206\016\021\035\022\036\020\034\004 \034\007\016\020\021\016 \035\ \030\201\016\024\035\022 \024\034\024\035\034\030\020\022\030 \025\034\027\ \003\020\032\002, \022\024\f\034\027\003\031\034)Tj 0 Tw (-)Tj 0.131 Tw T* (\036\037\020\022\022 \024\034\036\033\016\006\016\020\020\032\002 \036\037\ \033\022\037\020\035\034\036 \220\020\b\034\024\021\034\f\022\005\016\024\ \021\034\004 \022)Tj /Span<>> BDC ( )Tj EMC (\027\023\005\016\036\034\004 \036\022\031\023\037\027\022\031\037\007\022\ \022, \f\034\031\036\034\027\030\026\235\022\002 \036\032\030\036\022\035\ \003 \f\033\022\005\022\020\032 )Tj 0.08 Tw T* (\021\033\034\036\034\035\016\005\016\020\022\030, \023\024\035\037\020\034\ \036\022\035\003 \035\034\005\020\023\026 \027\034\021\037\027\022\031\037\ \007\022\026 \022\024\035\034\005\020\022\021\037 \022, \036)Tj /Span<>> BDC ( )Tj EMC (\023\024\027\034\036\022\030\002 \006\020\034\013\034\f\033\034\017\022\027\ \003\020\034\013\034 \024\035\037\007\022\034\020\037\033\037, )Tj 0.023 Tw T* (\036\032\f\034\027\020\022\035\003 \020\016\034\025\002\034\b\022\006\034\ \016 \036\032\024\034\021\034\035\016\002\020\034\027\034\013\022\005\020\ \034\016 \027\016\005\016\020\022\016.)Tj /T1_2 1 Tf 0.01 Tc 0.218 Tw 8 0 0 8 42.5596 312.3796 Tm [(\037\033\016\r\030\025\f\030)5( \026\033\036\025\021:)]TJ /T1_1 1 Tf 0 Tc 0.223 Tw 8.693 0 Td ( \035\034\027\024\035\034\021\022\001\016\005\020\034\016 \b\022\036\016\ \033\035\022\021\023\027\030\033\020\034\016 \021\033\034\036\034\035\016\ \005\016\020\022\016, \021\034\027\034\020\034\024\021\034\f\022\030, \021\ \034\006\f\003\026\035\016\033\020\037\030 \035\034\006\034\013\033\037\017\ \022\030 \024)Tj /Span<>> BDC ( )Tj EMC (\021\034\020\035\033\037\024\035\020\032\006 )Tj 0.023 Tw -8.698 -1.2 Td (\023\024\022\027\016\020\022\016\006, \037\033\035\016\033\022\034\013\033\ \037\017\022\030)Tj /T1_2 1 Tf 0.01 Tc 0.018 Tw 0.005 -1.909 Td [(\037\036\035\034\033\032\037\031)5( \032\035\031\030\027\030\026\036\025:)]TJ /T1_1 1 Tf 0 Tc 0.023 Tw 10.401 0 Td ( \037\036\035\034\033\032 \031\037\030\036\027\030\026\035 \034\025 \034\ \035\024\023\035\024\035\036\022\022 \021\034\020\017\027\022\021\035\037\ \022\020\035\016\033\016\024\034\036.)Tj /T1_2 1 Tf 0.01 Tc -0.01 Tw -10.401 -1.909 Td (\034\032\035\021\035\026\032\027\036\025\021\035\032\030:)Tj /T1_1 1 Tf 0 Tc 0.023 Tw 8.655 0 Td ( \022\024\024\027\016\b\034\036\037\020\022\016 \f\033\034\036\016\b\016\ \020\034 \025\016\031 \024\f\034\020\024\034\033\024\021\034\004 \f\034\b\ \b\016\033\201\021\022)Tj /T1_2 1 Tf 0.033 Tc 0.037 Tw -8.655 -2.617 Td [(\024\033\023)4.7( \022\032\031\032\027\036\025\021\035\032\023:)]TJ /T1_3 1 Tf 0.023 Tc 0.042 Tw 9.209 0 Td ( \225\022\021\024\r)Tj /Span<>> BDC ( )Tj EMC (\200.\203., \205\036\007\024\030\024\r)Tj /Span<>> BDC ( )Tj EMC (\202.\200., \216\024\007\024\030\022\024\r\f\022\017\005)Tj /Span<>> BDC ( )Tj EMC [(\204.\202. \212\017\026\020\027\024\f\021\017\022\026 \007\017\r\036\030\ \021\017\022\031\035\016\030\027\t\b \021\024\035\f\021\024\022\017\001\036\ \004\027\t\b \022\030\024\r\024\021\036\004\036\027\017\005)23( )]TJ 0.024 Tw -9.214 -1.2 Td (\(\024\002\024\030 \035\017\021\036\030\026\021\031\030\t\). )Tj /T1_1 1 Tf -0.023 Tw (\r\034\027\034\f\033\034\021\035\034\027\034\013\022\030.)Tj /T1_3 1 Tf 0.024 Tw [( )0.5(2025; )0.5(\021.)]TJ /Span<>> BDC ( )Tj EMC (24, \223)Tj /Span<>> BDC ( )Tj EMC (4, \f.)Tj /Span<>> BDC ( )Tj EMC (209\226217. https://doi.org/10.33878/2073-7556-2025-24-4-209-217)Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 0 Tc 0.023 Tw 18 0 0 18 83.3597 209.364 Tm [(Diagnostics of\022)-23.3(div)12(er)-19.9(ticular colonic bleeding \(r)31(e)11(vie)11(w\))]TJ 0 0 0 1 k /GS1 gs 0 Tw 14 0 0 14 42.5197 184.86 Tm [(Vladimir\022)-23.2(N.\022)-23.3(Ektov)]TJ 8.162 0 0 8.162 140.9741 189.522 Tm (1)Tj 0.023 Tw 14 0 0 14 145.61 184.86 Tm [(, Andr)31(ey\022)-23.2(V)62(.\022)-23.3(F)20(edor)20(ov)]TJ 0 Tw 8.162 0 0 8.162 258.6852 189.522 Tm (2)Tj 0.023 Tw 14 0 0 14 263.3212 184.86 Tm [(, Mark\022)-23.2(A)-31(.\022)-23.3(Kh)11(odork)11(ov)10(sky)]TJ 0 Tw 8.162 0 0 8.162 401.2176 189.522 Tm (1)Tj 5.83 0 0 5.83 42.5197 170.5207 Tm (1)Tj 0.023 Tw 10 0 0 10 45.8311 167.1907 Tm [(Bur)31(denk)11.1(o V)30.1(or)20(one)21(zh State Medical Univ)12(er)20.1(sit)-20(y \(Studench)11.1(eskay)21(a\022)-23.3(st., 1)75(0, V)30(or)20(one)21(zh, 3)11(9)80(4036, Russia\))]TJ 0 Tw ( )Tj 5.83 0 0 5.83 42.5197 158.5208 Tm (2)Tj 0.023 Tw 10 0 0 10 45.8311 155.1908 Tm [(Vishne)11.1(v)9.9(sky National Medical Resear)31.1(ch Center of\022)-23.2(Sur)31(ger)-31(y \(Bol'shay)21.1(a Serpuh)10.9(ov)10(skay)21.1(a\022)-23.3(st., 2)46(7)127(, Moscow)22(, 1)212(1)138(7)35(99)35(7)127(, )]TJ 0 Tw -0.331 -1.2 Td (Russia\))Tj /T1_1 1 Tf 0.067 Tw 9 0 0 9 90.7087 124.6869 Tm (AIM: to)Tj /Span<>> BDC ( )Tj EMC (analyze the)Tj /Span<>> BDC ( )Tj EMC [(published d)26(ata on the)]TJ /Span<>> BDC ( )Tj EMC (diagnosis of)Tj /Span<>> BDC ( )Tj EMC [(div)13(er)-39.9(ticular bleeding and to)]TJ /Span<>> BDC ( )Tj EMC (justify the)Tj /Span<>> BDC ( )Tj EMC (choice of)Tj /Span<>> BDC ( )Tj EMC [(ef)-40(fectiv)12.9(e )]TJ 0.023 Tw T* [(app)46(roach for the)]TJ /Span<>> BDC ( )Tj EMC (clinical checkup of)Tj /Span<>> BDC ( )Tj EMC (these patients.)Tj -0.029 Tw T* [(MA)45(TERIAL)-27.9(S A)53(ND METHODS: )0.5(a)]TJ /Span<>> BDC ( )Tj EMC [(systematic literature )0.5(search w)13(as car)-16(r)-36.9(ied out on electronic d)26(ata bases Librar)-42.9(y)32(.ru, PubMed )]TJ 0.08 Tw T* [(and )0.5(Cochrane )0.6(Librar)-43(y )0.6(2005\2262025. )0.5(T)53(o)]TJ /Span<>> BDC ( )Tj EMC 14.962 0 Td [(collect )0.6(the)]TJ /Span<>> BDC ( )Tj EMC 4.458 0 Td [(published )0.6(d)26(ata, )0.5(search )0.5(q)14(uer)-37(ies )0.5(w)12(ere )0.5(used)]TJ /Span<>> BDC ( )Tj EMC 16.523 0 Td [(\227 )0.5(colonic )0.5(bleeding )0.5(OR )]TJ -0.026 Tw -35.943 -1.111 Td [(colonic )0.5(div)13(er)-40(ticular )0.5(bleeding )0.5(A)53(ND colonoscop)12.1(y )0.5(A)53(ND contrast-enhanced )0.6(com)16(puted )0.5(tomog)14(raph)12(y )0.5(A)53(ND )0.5(ar)-40(ter)-37(iog)14(raph)11.9(y A)53(ND )]TJ ET 1 0.68 0 0.12 k /GS0 gs q 1 0 0 1 42.5197 586.1533 cm 0 0 m 0 0 l 0 -11.339 l 42.52 -11.339 l 42.52 0 l h f Q BT 0 0 0 0 k /T1_2 1 Tf 0 Tw 9 0 0 9 47.6607 577.226 Tm (\027\030\013\016\n\030)Tj ET 1 0.68 0 0.12 k q 1 0 0 1 42.5197 133.1914 cm 0 0 m 0 0 l 0 -11.339 l 42.52 -11.339 l 42.52 0 l h f Q BT 0 0 0 0 k /T1_2 1 Tf 9 0 0 9 45.2263 124.2641 Tm (ABSTRACT)Tj 1 0.68 0 0.12 k /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\206)10(\002\036\033 \035\030\032\003\033)30(\n)42(\032)-21(\230\033\241)]TJ 57.136 0 Td (REVIEW)Tj /T1_4 1 Tf 25 0 0 25 506.3396 56.0378 Tm (209)Tj ET q 0 g 0 G 0 j 0 J /Fm1 Do Q 0 0 0 0 k 368.504 725.67 59.155 11.338 re f /PlacedPDF /MC0 BDC q 369.135 736.808 m 368.896 736.808 368.703 736.616 368.703 736.376 c 368.703 736.376 l 368.703 726.285 l 368.703 726.045 368.896 725.853 369.135 725.853 c 369.135 725.853 l 427.035 725.853 l 427.273 725.853 427.469 726.045 427.469 726.285 c 427.469 726.285 l 427.469 736.376 l 427.469 736.616 427.273 736.808 427.035 736.808 c 427.035 736.808 l h W n q 0 g -0.0000005 -10.9560913 -10.9560913 0.0000005 398.0855785 736.8086309 cm BX /Sh0 sh EX Q Q q 368.504 725.67 59.155 11.337 re W n 0 0 0 0.84 k q 1 0 0 1 385.2169 732.4249 cm 0 0 m -0.025 0.1 -0.063 0.196 -0.112 0.287 c -0.157 0.374 -0.218 0.451 -0.292 0.515 c -0.37 0.582 -0.46 0.632 -0.558 0.664 c -0.669 0.701 -0.786 0.719 -0.903 0.717 c -1.076 0.722 -1.247 0.681 -1.4 0.6 c -1.536 0.526 -1.652 0.42 -1.74 0.292 c -1.83 0.158 -1.895 0.008 -1.934 -0.149 c -2.018 -0.48 -2.018 -0.827 -1.934 -1.158 c -1.896 -1.316 -1.83 -1.466 -1.74 -1.602 c -1.653 -1.731 -1.536 -1.837 -1.4 -1.912 c -1.247 -1.993 -1.076 -2.033 -0.903 -2.029 c -0.774 -2.032 -0.647 -2.006 -0.528 -1.955 c -0.427 -1.906 -0.337 -1.837 -0.263 -1.753 c -0.185 -1.665 -0.124 -1.563 -0.082 -1.453 c -0.034 -1.338 0 -1.218 0.019 -1.094 c 0.635 -1.094 l 0.624 -1.297 0.578 -1.497 0.497 -1.684 c 0.421 -1.857 0.312 -2.015 0.175 -2.146 c 0.039 -2.277 -0.123 -2.379 -0.3 -2.446 c -0.492 -2.519 -0.695 -2.555 -0.9 -2.552 c -1.15 -2.557 -1.397 -2.506 -1.625 -2.404 c -1.829 -2.307 -2.01 -2.169 -2.157 -1.997 c -2.308 -1.821 -2.423 -1.617 -2.497 -1.397 c -2.655 -0.924 -2.655 -0.412 -2.497 0.061 c -2.423 0.281 -2.307 0.485 -2.157 0.661 c -2.01 0.833 -1.829 0.973 -1.625 1.07 c -1.398 1.174 -1.15 1.226 -0.9 1.222 c -0.707 1.223 -0.515 1.196 -0.329 1.14 c -0.159 1.088 0.001 1.006 0.144 0.898 c 0.278 0.793 0.39 0.662 0.473 0.513 c 0.562 0.349 0.615 0.167 0.629 -0.019 c 0 -0.019 l 0 0 l f Q q 1 0 0 1 386.3458 733.5723 cm 0 0 m 0.584 0 l 0.584 -1.328 l 0.662 -1.204 0.771 -1.103 0.9 -1.033 c 1.046 -0.951 1.213 -0.91 1.381 -0.914 c 1.627 -0.9 1.869 -0.979 2.058 -1.137 c 2.234 -1.312 2.325 -1.556 2.305 -1.803 c 2.305 -3.596 l 1.716 -3.596 l 1.716 -1.976 l 1.724 -1.817 1.678 -1.66 1.585 -1.53 c 1.486 -1.43 1.347 -1.379 1.206 -1.392 c 1.114 -1.39 1.024 -1.408 0.94 -1.445 c 0.865 -1.479 0.798 -1.529 0.744 -1.591 c 0.687 -1.656 0.645 -1.73 0.616 -1.812 c 0.586 -1.896 0.571 -1.986 0.571 -2.077 c 0.571 -3.615 l 0 -3.615 l 0 0 l f Q q 1 0 0 1 389.692 731.1235 cm 0 0 m 0 -0.099 0.014 -0.198 0.043 -0.292 c 0.069 -0.382 0.112 -0.466 0.17 -0.54 c 0.229 -0.611 0.304 -0.669 0.388 -0.709 c 0.486 -0.754 0.594 -0.776 0.702 -0.773 c 0.845 -0.78 0.987 -0.742 1.108 -0.664 c 1.217 -0.582 1.296 -0.468 1.336 -0.337 c 1.881 -0.337 l 1.827 -0.603 1.675 -0.838 1.456 -0.996 c 1.35 -1.073 1.231 -1.131 1.105 -1.169 c 0.971 -1.208 0.831 -1.229 0.691 -1.227 c 0.509 -1.227 0.328 -1.191 0.16 -1.121 c 0.007 -1.063 -0.13 -0.972 -0.244 -0.855 c -0.356 -0.73 -0.44 -0.583 -0.491 -0.422 c -0.548 -0.243 -0.576 -0.056 -0.574 0.133 c -0.575 0.313 -0.545 0.493 -0.486 0.664 c -0.426 0.826 -0.335 0.974 -0.22 1.102 c 0.004 1.375 0.338 1.534 0.691 1.535 c 0.883 1.539 1.072 1.495 1.243 1.408 c 1.402 1.326 1.541 1.209 1.649 1.067 c 1.759 0.922 1.838 0.757 1.883 0.582 c 1.932 0.396 1.945 0.203 1.92 0.013 c 0 0.013 l 0 0 l 1.342 0.377 m 1.335 0.468 1.315 0.557 1.283 0.643 c 1.253 0.724 1.209 0.798 1.153 0.863 c 1.097 0.922 1.03 0.97 0.957 1.004 c 0.874 1.043 0.783 1.063 0.691 1.062 c 0.6 1.062 0.509 1.044 0.425 1.009 c 0.345 0.976 0.273 0.926 0.213 0.863 c 0.153 0.799 0.105 0.724 0.072 0.643 c 0.037 0.559 0.017 0.468 0.014 0.377 c 1.355 0.377 l h f Q q 1 0 0 1 393.8116 731.7051 cm 0 0 m -0.012 0.144 -0.082 0.276 -0.194 0.366 c -0.31 0.452 -0.451 0.495 -0.595 0.489 c -0.675 0.488 -0.755 0.476 -0.831 0.452 c -0.918 0.424 -0.998 0.375 -1.062 0.311 c -1.142 0.229 -1.202 0.131 -1.24 0.024 c -1.29 -0.132 -1.312 -0.296 -1.304 -0.459 c -1.304 -0.569 -1.292 -0.677 -1.267 -0.784 c -1.244 -0.885 -1.202 -0.983 -1.145 -1.07 c -1.09 -1.154 -1.016 -1.224 -0.93 -1.275 c -0.833 -1.33 -0.722 -1.356 -0.611 -1.352 c -0.457 -1.357 -0.307 -1.301 -0.194 -1.195 c -0.078 -1.077 -0.005 -0.922 0.011 -0.757 c 0.587 -0.757 l 0.556 -1.055 0.419 -1.332 0.202 -1.538 c -0.022 -1.721 -0.306 -1.815 -0.595 -1.803 c -0.777 -1.806 -0.958 -1.771 -1.126 -1.7 c -1.293 -1.642 -1.445 -1.547 -1.57 -1.421 c -1.68 -1.297 -1.763 -1.151 -1.814 -0.993 c -1.87 -0.822 -1.898 -0.643 -1.896 -0.462 c -1.898 -0.276 -1.871 -0.091 -1.817 0.087 c -1.766 0.252 -1.682 0.405 -1.57 0.537 c -1.459 0.664 -1.323 0.766 -1.168 0.834 c -0.991 0.914 -0.798 0.955 -0.603 0.954 c -0.457 0.954 -0.311 0.935 -0.17 0.895 c -0.039 0.858 0.084 0.799 0.194 0.72 c 0.302 0.643 0.393 0.543 0.459 0.428 c 0.531 0.298 0.572 0.155 0.582 0.008 c 0 0.008 l 0 0 l f Q q 1 0 0 1 394.8712 733.5723 cm 0 0 m 0.577 0 l 0.577 -2.048 l 1.615 -0.985 l 2.322 -0.985 l 1.323 -1.944 l 2.417 -3.604 l 1.716 -3.604 l 0.919 -2.337 l 0.577 -2.669 l 0.577 -3.604 l 0 -3.604 l h f Q q 1 0 0 1 398.712 732.5762 cm 0 0 m 0.436 0 l 0.436 0.218 l 0.429 0.352 0.448 0.486 0.488 0.614 c 0.521 0.705 0.577 0.786 0.651 0.85 c 0.717 0.905 0.795 0.943 0.879 0.961 c 0.966 0.979 1.056 0.988 1.145 0.988 c 1.28 0.993 1.416 0.981 1.548 0.954 c 1.548 0.505 l 1.509 0.516 1.469 0.523 1.429 0.528 c 1.379 0.532 1.33 0.532 1.28 0.528 c 1.209 0.53 1.14 0.511 1.081 0.473 c 1.019 0.419 0.987 0.337 0.999 0.255 c 0.999 -0.011 l 1.498 -0.011 l 1.498 -0.441 l 1.009 -0.441 l 1.009 -2.622 l 0.436 -2.622 l 0.436 -0.428 l 0.005 -0.428 l 0.005 0 l 0 0 l f Q q 1 0 0 1 401.7535 729.8965 cm 0 0 m -0.191 -0.003 -0.381 0.032 -0.559 0.104 c -0.715 0.167 -0.856 0.264 -0.972 0.388 c -1.091 0.512 -1.181 0.659 -1.238 0.82 c -1.356 1.18 -1.356 1.567 -1.238 1.925 c -1.181 2.087 -1.091 2.234 -0.972 2.358 c -0.856 2.481 -0.715 2.578 -0.559 2.643 c -0.199 2.78 0.198 2.78 0.558 2.643 c 0.714 2.578 0.855 2.481 0.972 2.358 c 1.09 2.234 1.181 2.087 1.237 1.925 c 1.355 1.567 1.355 1.18 1.237 0.82 c 1.181 0.659 1.09 0.512 0.972 0.388 c 0.855 0.266 0.713 0.169 0.558 0.106 c 0.38 0.034 0.191 -0.002 0 0 c 0 0.454 m 0.115 0.451 0.23 0.479 0.332 0.534 c 0.424 0.586 0.502 0.659 0.562 0.746 c 0.624 0.836 0.669 0.936 0.695 1.041 c 0.752 1.26 0.752 1.491 0.695 1.71 c 0.669 1.816 0.625 1.916 0.562 2.005 c 0.502 2.091 0.423 2.163 0.332 2.215 c 0.123 2.323 -0.126 2.323 -0.335 2.215 c -0.427 2.163 -0.505 2.091 -0.566 2.005 c -0.628 1.916 -0.673 1.816 -0.699 1.71 c -0.756 1.491 -0.756 1.26 -0.699 1.041 c -0.672 0.936 -0.627 0.836 -0.566 0.746 c -0.506 0.659 -0.427 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P)30(er)-23.9(for)-33(a)15(ted col)30(or)-24(ec)-16(t)15.1(al cancer: an)]TJ /Span<>> BDC ( )Tj EMC [(im)10(por)-22(t)15(ant )]TJ 0.205 Tw -1.796 -1.25 Td [(dif)-56(fer)-23.9(ent)-32(ial dia)-17(gnosis in all p)25(r)-24(esumed di)-16(ver)-22(t)-31.9(icul)-16(ar abscesses. )]TJ /T1_1 1 Tf 0 Tw (Ann )Tj 0.023 Tw T* [(Acad Med Sing)12(ap)]TJ /T1_0 1 Tf (. 2011;40\(8\):375\226378. PMID: 21939155)Tj -0.004 Tc -0.025 Tw T* (63.)Tj /Span<>> BDC ( )Tj EMC 1.78 0 Td [(de V)15.9(r)-36.9(ies)]TJ /Span<>> BDC ( )Tj EMC [(HS, Boer)-15.9(ma)]TJ /Span<>> BDC ( )Tj EMC [(D, T)35(immer)]TJ /Span<>> BDC ( )Tj EMC [(R, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. R)11(out)-32(ine col)30(onoscopy is no)17(t)-4( )]TJ 0.15 Tw -1.78 -1.25 Td [(r)-24(equir)-24(ed in uncom)10(pl)-31(ica)15.1(ted di)-15.9(ver)-22(t)-32(icul)-31(i)-24(t)-32(is: a)]TJ /Span<>> BDC ( )Tj EMC [(sy)-13(stema)15(t)-32(ic r)-24(ev)-16(iew. )]TJ /T1_1 1 Tf 0.004 Tw [(Surg)-4( )]TJ T* (Endosc. )Tj /T1_0 1 Tf 0.023 Tw 3.225 0 Td [(2014;28\(7\):2039\2262047. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0.004 Tw (10.1007/s00464-014-3436-7)Tj 0 0 0 1 k /GS1 gs 0 Tc 0.253 Tw -3.225 -1.25 Td (64.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(R)11(ossi)]TJ /Span<>> BDC ( )Tj EMC 2.558 0 Td [(GL, )0.6(Mentz)]TJ /Span<>> BDC ( )Tj EMC 4.561 0 Td [(R, )0.6(Ber)-22(t)17(one)]TJ /Span<>> BDC ( )Tj EMC 4.854 0 Td [(S, )0.6(e)-12(t)]TJ /Span<>> BDC ( )Tj EMC 2.45 0 Td [(al. )0.6(L)-32(ap)32(ar)-32(oscopic )0.6(per)-37(i)-24(t)17(oneal )]TJ 0.055 Tw -16.219 -1.25 Td [(l)-16(av)-15(a)-17(ge for Hinche)-10.9(y III di)-15.9(ver)-22(t)-32(icul)-30.9(i)-24(t)-32(is: is i)-24(t as ef)-56(fec)-16(t)-31.9(i)-16(ve as i)-24(t is appl)-31(i)]TJ 0 Tw (-)Tj T* (cable? )Tj /T1_1 1 Tf 0.276 Tw 3.06 0 Td [(Dis )0.5(Colon )0.5(R)21.1(ectum.)]TJ /T1_0 1 Tf [( )0.5(2014;57\(12\):1384\2261390. )0.5(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw 20.838 0 Td (10.1097/)Tj -23.899 -1.25 Td (DCR.0000000000000243)Tj 0 0 0 1 k /GS1 gs 0.319 Tw T* (65.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Sw)-12(ank)]TJ /Span<>> BDC ( )Tj EMC [(H)49.1(A, Mulder)]TJ /Span<>> BDC ( )Tj EMC 8.216 0 Td [(IM, Ho)-16(of)-25.9(wijk)]TJ /Span<>> BDC ( )Tj EMC [(A)16.1(G, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. )0.5(Ear)-30(l)35(y e)-17.9(xper)-37(ience )]TJ 0.243 Tw -10.012 -1.25 Td [(wi)-24(t)-13(h l)-15.9(ap)32(ar)-32(oscopic l)-16(av)-15(a)-17(ge for per)-23.9(for)-33(a)15(ted di)-16(ver)-21.9(t)-32(icul)-31(i)-24(t)-32(is. )]TJ /T1_1 1 Tf (Br J Surg.)Tj /T1_0 1 Tf 0 Tw ( )Tj 0.023 Tw T* [(2013;100\(5\):704\226710. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1002/bjs.9063)Tj 0 0 0 1 k /GS1 gs 0.086 Tw T* (66.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Angene)-12(te)]TJ /Span<>> BDC ( )Tj EMC [(E, T)47(hor)-15(nell)]TJ /Span<>> BDC ( )Tj EMC [(A, Bur)-32(char)-22(t)-13(h)]TJ /Span<>> BDC ( )Tj EMC [(J, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. L)-32(ap)32(ar)-32(oscopic l)-16(av)-14.9(a)-17(ge )]TJ 0.196 Tw -1.796 -1.25 Td [(is feasible and safe for t)-12.9(he)]TJ /Span<>> BDC ( )Tj EMC [(tr)-24(ea)15(tment of)]TJ /Span<>> BDC ( )Tj EMC [(per)-23.9(for)-33(a)15(ted di)-16(ver)-21.9(t)-32(icul)-31(i)-23.9(t)-32(is )]TJ 0.017 Tw T* [(wi)-24(t)-13(h pur)-21.9(ulent per)-37(i)-24(t)17(oni)-24(t)-31.9(is: t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(f)-28(ir)-9.9(st r)-23.9(esul)56(ts fr)-32(om t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(r)-32.9(and)-16(omized con)]TJ 0 Tw (-)Tj 0.031 Tw T* [(tr)-32(olled )0.5(tr)-37(ial DIL)-34.9(AL)-35(A. )]TJ /T1_1 1 Tf 8.472 0 Td (Ann Surg.)Tj /T1_0 1 Tf [( )0.5(2016;263\(1\):117\226122. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw 15.427 0 Td (10.1097/)Tj -23.899 -1.25 Td [(SL)-35(A.0000000000001061)]TJ 0 0 0 1 k /GS1 gs -0.036 Tw T* (67.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(S)-24(chul)56(tz)]TJ /Span<>> BDC ( )Tj EMC [(JK, Y)50(aqub)]TJ /Span<>> BDC ( )Tj EMC [(S, W)12(all)30(on)]TJ /Span<>> BDC ( )Tj EMC [(C, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. L)-31.9(ap)32(ar)-32(oscopic l)-16(av)-15(a)-17(ge vs p)25(r)-37(ima)]TJ 0 Tw (-)Tj -0.029 Tw -1.796 -1.25 Td [(r)-24(y r)-24(esec)-15.9(t)-32(ion for a)-17(cute per)-24(for)-33(a)15(ted di)-16(ver)-21.9(t)-32(icul)-31(i)-23.9(t)-32(is: t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(SC)20(A)51(NDIV r)-33(and)-16(om)]TJ 0 Tw (-)Tj 0.192 Tw T* [(ized cl)-31(inical tr)-37(ial. )]TJ /T1_1 1 Tf 0 Tw [(J)30(AMA)]TJ /T1_0 1 Tf 0.192 Tw [(. 2015;314\(13\):1364\2261375. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1001/)Tj T* (jama.2015.12076)Tj 0 0 0 1 k /GS1 gs 0.087 Tw T* (68.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(V)30(ennix)]TJ /Span<>> BDC ( )Tj EMC [(S, Muster)-9.9(s)]TJ /Span<>> BDC ( )Tj EMC (GD, Mulder)Tj /Span<>> BDC ( )Tj EMC [(IM, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. L)-32(ap)32(ar)-32(oscopic per)-37(i)-24(t)17(oneal )]TJ 0.071 Tw -1.796 -1.25 Td [(l)-16(av)-15(a)-17(ge or sigmoidec)-16(t)17(omy for per)-23.9(for)-33(a)15(ted di)-16(ver)-21.9(t)-32(icul)-31(i)-24(t)-31.9(is wi)-24(t)-13(h pur)-22(ulent )]TJ 0.286 Tw T* [(per)-37(i)-23.9(t)17(oni)-24(t)-32(is: )0.6(a)]TJ /Span<>> BDC ( )Tj EMC 6.129 0 Td [(mul)56(t)-32(icentr)-23.9(e, )0.5(p)32(ar)-32.9(allel-gr)-32(oup, )0.6(r)-33(and)-16(omised, )0.6(open-l)-16(abel )]TJ 0.002 Tc -0.002 Tw -6.129 -1.25 Td [(t)0.5(r)-36.4(i)0.5(a)0.6(l)0.5(.)0.5( )]TJ /T1_1 1 Tf 2.594 0 Td [(L)0.5(a)0.6(n)0.5(c)0.6(e)0.5(t)]TJ /T1_0 1 Tf 0.349 Tw 2.588 0 Td [(.)0.5( 2)0.5(0)0.6(1)0.5(5)0.5(;)0.6(3)0.5(8)0.5(6)0.6(\()0.5(1)0.5(0)0.5(0)0.6(0)0.5(0)0.5(\))0.6(:)0.5(1)0.5(2)0.6(6)0.5(9)0.5(\226)0.6(1)0.5(2)0.5(7)0.5(7)0.6(.)0.5( d)-15.5(o)0.5(i)0.6(:)]TJ /Span<>> BDC 15.299 0 Td ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs -0.002 Tw [(1)0.5(0)0.5(.)0.6(1)0.5(0)0.5(1)0.6(6)0.5(/)0.5(S)0.5(0)0.6(1)0.5(4)0.5(0)0.6(-)]TJ 0 Tc 0 Tw -20.481 -1.25 Td (6736\(15\)61168-0)Tj 0 0 0 1 k /GS1 gs 0.204 Tw T* (69.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(P)30(enna)]TJ /Span<>> BDC ( )Tj EMC [(M, Mar)-23.9(k)-17(ar)]TJ /Span<>> BDC ( )Tj EMC [(SR, Ma)-17(ck)10(enzie)]TJ /Span<>> BDC ( )Tj EMC [(H, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. L)-31.9(ap)32(ar)-32(oscopic l)-16(av)-15(a)-17(ge )]TJ 0.105 Tw -1.796 -1.25 Td [(ver)-10(sus p)25(r)-37(imar)-24(y r)-24(esec)-15.9(t)-32(ion for a)-17(cute per)-23.9(for)-33(a)15(ted di)-16(ver)-21.9(t)-32(icul)-31(i)-23.9(t)-32(is: r)-24(ev)-16(iew )]TJ 0.136 Tw T* [(and me)-12(t)15.1(a-anal)35(y)-13(sis. )]TJ /T1_1 1 Tf (Ann Surg)Tj /T1_0 1 Tf [(. 2018;267\(2\):252\226258. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1097/)Tj T* [(SL)-35(A.0000000000002235)]TJ 0 0 0 1 k /GS1 gs 0.227 Tw T* (70.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Galbr)-33(ai)-23.9(t)-13(h)]TJ /Span<>> BDC ( )Tj EMC [(N, Car)-22(ter)]TJ /Span<>> BDC ( )Tj EMC [(JV, Ne)-12(tz)]TJ /Span<>> BDC ( )Tj EMC [(U, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. L)-31.9(ap)32(ar)-32(oscopic l)-16(av)-15(a)-16.9(ge in )]TJ 0.056 Tw -1.796 -1.25 Td [(t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(mana)-17(gement of)]TJ /Span<>> BDC ( )Tj EMC [(per)-24(for)-32.9(a)15(ted di)-16(ver)-22(t)-32(icul)-30.9(i)-24(t)-32(is: a)]TJ /Span<>> BDC ( )Tj EMC [(contem)10(por)-32.9(ar)-24(y me)-12(t)15(a-)]TJ 0 Tw T* [(anal)35(y)-13(sis. )]TJ /T1_1 1 Tf 0.087 Tw 3.8 0 Td (J Gastrointest Surg.)Tj /T1_0 1 Tf [( 2017;21\(9\):1491\2261499. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1007/)Tj -3.8 -1.25 Td (s11605-017-3485-z)Tj 0 0 0 1 k /GS1 gs 0.205 Tw T* (71.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Hong)Tj /Span<>> BDC ( )Tj EMC [(MK, T)45(oml)-30.9(in)]TJ /Span<>> BDC ( )Tj EMC [(AM, Ha)15(yes)]TJ /Span<>> BDC ( )Tj EMC [(IP, e)-11.9(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Oper)-33(a)15(t)-32(i)-16(ve inter)-31.9(vent)-32(ion )]TJ 0.084 Tw -1.796 -1.25 Td [(r)-33(a)15(tes for a)-17(cute di)-16(ver)-21.9(t)-32(icul)-31(i)-24(t)-32(is: a)]TJ /Span<>> BDC ( )Tj EMC [(mul)56.1(t)-32(icentr)-24(e st)15(a)15(te-wide stud)17(y. )]TJ /T1_1 1 Tf [(A)53(NZ J )]TJ 0 Tw 29.055 81.25 Td (Surg.)Tj /T1_0 1 Tf 0.023 Tw [( 2015;85\(10\):734\226738. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1111/ans.12868)Tj 0 0 0 1 k /GS1 gs 0.085 Tw T* (72.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(L)-32(i)]TJ /Span<>> BDC ( )Tj EMC (D, Baxter)Tj /Span<>> BDC ( )Tj EMC [(NN, McL)35(eod)]TJ /Span<>> BDC ( )Tj EMC [(RS, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Evol)30(v)-15.9(ing p)25(r)-33(a)-17(c)-16(t)-32(ice p)32(a)15(t)-30(ter)-14.9(ns in )]TJ 0.045 Tw -1.796 -1.25 Td [(t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(mana)-17(gement of)]TJ /Span<>> BDC ( )Tj EMC [(a)-17(cute col)30(onic di)-16(ver)-21.9(t)-32(icul)-31(i)-23.9(t)-32(is: a)]TJ /Span<>> BDC ( )Tj EMC [(popul)-16(a)15.1(t)-32(ion-based )]TJ 0 Tw T* [(anal)35(y)-13(sis. )]TJ /T1_1 1 Tf 0.121 Tw 3.834 0 Td [(Dis Colon R)21(ectum.)]TJ /T1_0 1 Tf [( 2014;57\(12\):1397\2261405. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1097/)Tj -3.834 -1.25 Td (DCR.0000000000000230)Tj 0 0 0 1 k /GS1 gs 0.075 Tw T* (73.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Chandr)-33(a)]TJ /Span<>> BDC ( )Tj EMC (V, Nelson)Tj /Span<>> BDC ( )Tj EMC [(H, L)-32(ar)-9.9(son)]TJ /Span<>> BDC ( )Tj EMC [(DR, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Im)10.1(p)32(a)-17(c)-16(t of)]TJ /Span<>> BDC ( )Tj EMC [(p)25.1(r)-37(imar)-24(y r)-24(esec)]TJ 0 Tw (-)Tj 0.053 Tw -1.796 -1.25 Td [(t)-32(ion )0.5(on )0.6(t)-13(he)]TJ /Span<>> BDC ( )Tj EMC 4.908 0 Td [(outcome )0.6(of)]TJ /Span<>> BDC ( )Tj EMC 4.881 0 Td [(p)32(a)15(t)-32(ients )0.6(wi)-24(t)-13(h )0.5(per)-23.9(for)-33(a)15(ted )0.5(di)-15.9(ver)-22(t)-32(icul)-30.9(i)-24(t)-32(is. )]TJ /T1_1 1 Tf 0 Tw 16.107 0 Td (Arch )Tj -25.896 -1.25 Td (Surg.)Tj /T1_0 1 Tf -0.014 Tw [( 2004;139\(11\):1221\2261224. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw [(10.1001/ar)-32(chsur)-31.9(g.139.11.1221)]TJ 0 0 0 1 k /GS1 gs 0.111 Tw T* (74.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Cir)-32(o)-16(cchi)]TJ /Span<>> BDC ( )Tj EMC [(R, T)50(r)-33(astull)-30.9(i)]TJ /Span<>> BDC ( )Tj EMC [(S, Desider)-37(io)]TJ /Span<>> BDC ( )Tj EMC [(J, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. T)50(r)-23.9(ea)15(tment of)]TJ /Span<>> BDC ( )Tj EMC [(Hinche)-11(y )]TJ 0.163 Tw -1.796 -1.25 Td [(st)15(a)-17(ge III-IV di)-16(ver)-22(t)-32(icul)-30.9(i)-24(t)-32(is: a)]TJ /Span<>> BDC ( )Tj EMC [(sy)-12.9(stema)15(t)-32(ic r)-24(ev)-16(iew and me)-12(t)15(a-anal)35(y)-13(sis. )]TJ /T1_1 1 Tf 0.026 Tw T* (Int J Colorectal Dis.)Tj /T1_0 1 Tf [( 2013; 28\(4\) 447-457. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1007/s00384-012-)Tj T* (1622-4)Tj 0 0 0 1 k /GS1 gs 0.106 Tw T* (75.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(L)35(ee)]TJ /Span<>> BDC ( )Tj EMC 1.681 0 Td [(JM, )0.5(Bai)]TJ /Span<>> BDC ( )Tj EMC 3.268 0 Td [(P, )0.5(Chang)]TJ /Span<>> BDC ( )Tj EMC 3.841 0 Td [(J, )0.5(e)-11.9(t)]TJ /Span<>> BDC ( )Tj EMC 2.144 0 Td [(al. )0.6(Har)-22(tmann\246s )0.6(p)25(r)-32(o)-16(cedur)-24(e )0.6(vs )0.5(p)25(r)-37(imar)-23.9(y )]TJ 0.127 Tw -12.73 -1.25 Td [(anast)17(omosis wi)-24(t)-13(h di)-15.9(ver)-22(t)-32(ing l)30.1(o)-16(op ileost)17(omy for a)-17(cute di)-16(ver)-21.9(t)-32(icul)-31(i)-23.9(t)-32(is: )]TJ 0.081 Tw T* [(na)15(t)-32(ionwide anal)35(y)-12.9(sis of)]TJ /Span<>> BDC ( )Tj EMC [(2,729 emer)-32(gency sur)-32(ger)-24(y p)32(a)15(t)-32(ients. )]TJ /T1_1 1 Tf (J Am Coll )Tj 0 Tw T* (Surg)Tj /T1_0 1 Tf 0.023 Tw [(. 2019;229\(1\):48\22655. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw [(10.1016/j.jamcollsur)-31.9(g.2019.03.007)]TJ 0 0 0 1 k /GS1 gs 0.054 Tw T* (76.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Const)15(ant)-32(inides)]TJ /Span<>> BDC ( )Tj EMC [(V)36.9(A, Her)-36.9(io)17(t)]TJ /Span<>> BDC ( )Tj EMC [(A, R)13(emzi)]TJ /Span<>> BDC ( )Tj EMC [(F, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Oper)-33(a)15(t)-32(i)-16(ve str)-32.9(a)15(tegies )]TJ 0.282 Tw -1.796 -1.25 Td [(for di)-16(ver)-21.9(t)-32(icul)-16(ar per)-36.9(i)-24(t)17(oni)-24(t)-32(is: a)]TJ /Span<>> BDC ( )Tj EMC [(dec)-24(ision anal)35(y)-13(sis be)-12(t)-32(ween p)25(r)-37(imar)-23.9(y )]TJ 0.051 Tw T* [(r)-24(esec)-15.9(t)-32(ion and anast)17(omosis ver)-9.9(sus Har)-22(tmann\246s )0.5(p)25(r)-32(o)-16(cedur)-24(es. )]TJ /T1_1 1 Tf (Ann Surg.)Tj /T1_0 1 Tf 0 Tw ( )Tj 0.023 Tw T* [(2007;245\(1\):94\226103. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw [(10.1097/01.sl)-16(a.0000231758.07868.71)]TJ 0 0 0 1 k /GS1 gs 0.086 Tw T* (77.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(L)-32(ambr)-36.9(ichts)]TJ /Span<>> BDC ( )Tj EMC [(DPV, )0.5(V)29.9(ennix)]TJ /Span<>> BDC ( )Tj EMC [(S, Muster)-9.9(s)]TJ /Span<>> BDC ( )Tj EMC [(GD, )0.5(e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. )0.5(Har)-22(tmann\246s p)25.1(r)-32(o)-16(ce)]TJ 0 Tw (-)Tj 0.051 Tw -1.796 -1.25 Td [(dur)-24(e ver)-9.9(sus sigmoidec)-16(t)17(omy wi)-23.9(t)-13(h p)25(r)-37(imar)-23.9(y anast)17.1(omosis for per)-24(for)-32.9(a)15(ted )]TJ 0.173 Tw T* [(di)-16(ver)-21.9(t)-32(icul)-31(i)-24(t)-31.9(is wi)-24(t)-13(h pur)-22(ulent or f)16(aecal per)-37(i)-23.9(t)17(oni)-24(t)-32(is \(L)-34.9(ADIES\): a)]TJ /Span<>> BDC ( )Tj EMC (mul)Tj 0 Tw (-)Tj 0.261 Tw T* [(t)-32(icentr)-23.9(e, p)32(ar)-33(allel-gr)-31.9(oup, r)-33(and)-16(omised, open-l)-16(abel, super)-37(ior)-36.9(i)-24(t)-10(y tr)-37(ial. )]TJ /T1_1 1 Tf 0.257 Tw T* (Lancet Gastroenterol Hepatol.)Tj /T1_0 1 Tf [( 2019; 4\(8\) 599-610. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1016/)Tj T* (S2468-1253\(19\)30174-8)Tj 0 0 0 1 k /GS1 gs -0.01 Tc 0.125 Tw T* (78.)Tj /Span<>> BDC ( )Tj EMC 1.756 0 Td [(Hal)-30.9(im)]TJ /Span<>> BDC ( )Tj EMC [(H, Ask)-17(ar)-37(i)]TJ /Span<>> BDC ( )Tj EMC (A, Nunn)Tj /Span<>> BDC ( )Tj EMC [(R, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. P)35(r)-36.9(imar)-24(y r)-23.9(esec)-16(t)-32(ion anast)17(omosis)-9.9( )]TJ -0.03 Tw -1.756 -1.25 Td [(ver)-9.9(sus Har)-22(tmann\246s p)25(r)-32(o)-15.9(cedur)-24(e in Hinche)-11(y III and IV di)-15.9(ver)-22(t)-32(icul)-31(i)-24(t)-31.9(is. )]TJ /T1_1 1 Tf 0.01 Tw [(W)29(orld)-10( )]TJ 0.023 Tw T* (J Emerg Surg.)Tj /T1_0 1 Tf [( 2019;14:Ar)-22(t. 32. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0.01 Tw (10.1186/s13017-019-0251-4)Tj 0 0 0 1 k /GS1 gs 0 Tc 0.207 Tw T* (79.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(V)30(ennix)]TJ /Span<>> BDC ( )Tj EMC [(S, Boer)-10(sema)]TJ /Span<>> BDC ( )Tj EMC [(GS, Busk)10.1(ens)]TJ /Span<>> BDC ( )Tj EMC [(CJ, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Emer)-31.9(gency l)-16(ap)32(ar)-32(o)]TJ 0 Tw (-)Tj 0.007 Tc 0.349 Tw -1.796 -1.25 Td [(scopic sigmoidec)-16(t)17.1(omy for per)-23.9(for)-32.9(a)15(ted di)-15.9(ver)-21.9(t)-32(icul)-31(i)-23.9(t)-31.9(is wi)-23.9(t)-13(h gener)]TJ 0 Tc 0 Tw 27.286 0 Td (-)Tj 0.142 Tw -27.286 -1.25 Td [(al)-31(ised per)-37(i)-23.9(t)17(oni)-24(t)-32(is: a)]TJ /Span<>> BDC ( )Tj EMC [(sy)-13(stema)15.1(t)-32(ic r)-24(ev)-16(iew. )]TJ /T1_1 1 Tf (Dig Surg.)Tj /T1_0 1 Tf ( 2016; 33\(1\) 1-7. )Tj 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1159/000441396)Tj 0 0 0 1 k /GS1 gs 0.303 Tw -1.847 -1.25 Td (80.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(W)22(eber)]TJ /Span<>> BDC ( )Tj EMC [(DG, Bendinell)-30.9(i)]TJ /Span<>> BDC ( )Tj EMC [(C, Bal)30.1(o)-16(gh)]TJ /Span<>> BDC ( )Tj EMC [(ZJ. Dama)-17(ge contr)-32(ol sur)-32(ger)-24(y )]TJ 0.341 Tw -1.796 -1.25 Td [(for )0.5(abd)-16(ominal )0.6(emer)-32(genc)-24(ies. )]TJ /T1_1 1 Tf 12.45 0 Td [(Br )0.5(J )0.5(Surg.)]TJ /T1_0 1 Tf ( 2014;101\(1\):e109\226e118. )Tj 0 Tw -12.45 -1.25 Td [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1002/bjs.9360)Tj 0 0 0 1 k /GS1 gs 0.168 Tw -1.847 -1.25 Td (81.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(T)40(ar)-22(t)15(a)-17(gl)-30.9(ia)]TJ /Span<>> BDC ( )Tj EMC [(D, Cost)15.1(a)]TJ /Span<>> BDC ( )Tj EMC (G, Camill\362)Tj /Span<>> BDC ( )Tj EMC [(A, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Dama)-17(ge contr)-32(ol sur)-31.9(ger)-24(y )]TJ 0.037 Tw -1.796 -1.25 Td [(for per)-24(for)-33(a)15(ted di)-16(ver)-21.9(t)-32(icul)-31(i)-23.9(t)-32(is wi)-23.9(t)-13(h dif)-55.9(fuse per)-36.9(i)-24(t)17(oni)-24(t)-32(is: saves l)-31(i)-16(ves and )]TJ 0.041 Tw T* [(r)-24(educes ost)17(omy. )]TJ /T1_1 1 Tf [(W)29(orld J Emerg Surg.)]TJ /T1_0 1 Tf [( 2019;14:Ar)-22(t. 19. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1186/)Tj T* (s13017-019-0238-1)Tj 0 0 0 1 k /GS1 gs 0.336 Tw T* (82.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Or)-24(d\363\361ez)]TJ /Span<>> BDC ( )Tj EMC 3.869 0 Td [(C)20(A, S\341nchez)]TJ /Span<>> BDC ( )Tj EMC 5.61 0 Td [(AI, P)-23.9(ined)42(a)]TJ /Span<>> BDC ( )Tj EMC [(J)15(A, )0.5(e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. )0.5(Defer)-24(r)-24(ed )0.5(p)25(r)-37(ima)]TJ 0 Tw (-)Tj 0.267 Tw -11.275 -1.25 Td [(r)-24(y anast)17(omosis ver)-10(sus di)-16(ver)-10(sion in p)32(a)15(t)-32(ients wi)-24(t)-13(h sever)-24(e second)]TJ 0 Tw (-)Tj 0.237 Tw T* [(ar)-24(y per)-36.9(i)-24(t)17(oni)-24(t)-32(is mana)-16.9(ged wi)-24(t)-13(h st)15(a)-16.9(ged l)-15.9(ap)32(ar)-32(o)17(t)17(omies. )]TJ /T1_1 1 Tf [(W)29(orld J Surg.)]TJ /T1_0 1 Tf 0 Tw ( )Tj 0.023 Tw T* [(2010;34\(1\):169\226176. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1007/s00268-009-0279-9)Tj 0 0 0 1 k /GS1 gs 0.079 Tw T* (83.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(S)-16(ohn)]TJ /Span<>> BDC ( )Tj EMC [(M, A)-24.9(gha)]TJ /Span<>> BDC ( )Tj EMC [(A, Hei)-24(tl)-15.9(and)]TJ /Span<>> BDC ( )Tj EMC [(W, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Dama)-17(ge contr)-32(ol str)-32.9(a)14.9(teg)16.1(y for )]TJ 0.133 Tw -1.796 -1.25 Td [(t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(tr)-24(ea)15(tment of)]TJ /Span<>> BDC ( )Tj EMC [(per)-24(for)-32.9(a)15(ted di)-16(ver)-21.9(t)-32(icul)-31(i)-23.9(t)-32(is wi)-24(t)-13(h gener)-33(al)-31(ized per)-37(i)-23.9(t)17(o)]TJ 0 Tw (-)Tj T* [(ni)-24(t)-32(is. )]TJ /T1_1 1 Tf 0.138 Tw 2.541 0 Td [(T)54(ech Colop)46(roctol.)]TJ /T1_0 1 Tf [( 2016;20\(8\):577\226583. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1007/s10151-)Tj -2.541 -1.25 Td (016-1498-3)Tj 0 0 0 1 k /GS1 gs 0.085 Tw T* (84.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(L)-32(i)]TJ /Span<>> BDC ( )Tj EMC (D, Baxter)Tj /Span<>> BDC ( )Tj EMC [(NN, McL)35(eod)]TJ /Span<>> BDC ( )Tj EMC [(RS, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Evol)30(v)-15.9(ing p)25(r)-33(a)-17(c)-16(t)-32(ice p)32(a)15(t)-30(ter)-14.9(ns in )]TJ 0.045 Tw -1.796 -1.25 Td [(t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(mana)-17(gement of)]TJ /Span<>> BDC ( )Tj EMC [(a)-17(cute col)30(onic di)-16(ver)-21.9(t)-32(icul)-31(i)-23.9(t)-32(is: a)]TJ /Span<>> BDC ( )Tj EMC [(popul)-16(a)15.1(t)-32(ion-based )]TJ 0 Tw T* [(anal)35(y)-13(sis. )]TJ /T1_1 1 Tf 0.121 Tw 3.834 0 Td [(Dis Colon R)21(ectum.)]TJ /T1_0 1 Tf [( 2014;57\(12\):1397\2261405. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1097/)Tj -3.834 -1.25 Td (DCR.0000000000000230)Tj 0 0 0 1 k /GS1 gs 0.011 Tc 0.405 Tw T* (85.)Tj /Span<>> BDC ( )Tj EMC 1.84 0 Td [(F)10.1(eingold)]TJ /Span<>> BDC ( )Tj EMC [(D, S)15.1(teele)]TJ /Span<>> BDC ( )Tj EMC [(SR, L)35.1(ee)]TJ /Span<>> BDC ( )Tj EMC [(S, e)-11.9(t)]TJ /Span<>> BDC ( )Tj EMC [(al. P)35.1(r)-32.8(a)-16.9(c)-15.9(t)-31.9(ice p)32.1(ar)-32.9(ame)-11.9(ter)-9.9(s)11( )]TJ 0.006 Tc 0.35 Tw -1.84 -1.25 Td [(for t)-13.3(he)]TJ /Span<>> BDC ( )Tj EMC [(tr)-24.3(ea)14.6(tment of)]TJ /Span<>> BDC ( )Tj EMC [(sigmoid di)-16.4(ver)-22.4(t)-32.4(icul)-31.4(i)-24.4(t)-32.3(is. )]TJ /T1_1 1 Tf [(Dis Colon R)20.6(ectum)]TJ /T1_0 1 Tf 0 Tc 0 Tw (. )Tj 0.023 Tw T* [(2014;57\(3\):284\226294. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1097/DCR.0000000000000075)Tj 0 0 0 1 k /GS1 gs 0.052 Tw T* (86.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(S)15(tr)-33(assle)]TJ /Span<>> BDC ( )Tj EMC [(PD, Kinl)-16(a)10(w)]TJ /Span<>> BDC ( )Tj EMC [(A)16(C, Chaumont)]TJ /Span<>> BDC ( )Tj EMC [(N, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. R)-10(a)15(tes of)]TJ /Span<>> BDC ( )Tj EMC [(elec)-16(t)-31.9(i)-16(ve col)]TJ 0 Tw (-)Tj 0.043 Tw -1.796 -1.25 Td [(ec)-16(t)17(omy )0.5(for )0.5(di)-16(ver)-21.9(t)-32(icul)-31(i)-24(t)-31.9(is cont)-31.9(inued )0.5(t)17(o)]TJ /Span<>> BDC ( )Tj EMC [(incr)-24(ease )0.5(af)-28(ter )0.5(2006 guidel)-30.9(ine )]TJ 0 Tw T* (change. )Tj /T1_1 1 Tf 3.55 0 Td (Gastroenterology)Tj /T1_0 1 Tf 0.116 Tw [(. 2019;157\(6\):1679\2261681. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1053/j.)Tj -3.55 -1.25 Td [(gastr)-32(o.2019.08.043)]TJ 0 0 0 1 k /GS1 gs 0.314 Tw T* (87.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(M)-24(or)-37(ini)]TJ /Span<>> BDC ( )Tj EMC [(S. A)-25(cute uncom)10(pl)-31(ica)15(ted di)-16(ver)-22(t)-32(icul)-30.9(i)-24(t)-32(is: Guidel)-31(ines on )]TJ 0.011 Tc 0.41 Tw -1.796 -1.25 Td [(Dia)-17(gnosis )0.5(and Mana)-17.1(gement: )0.5(is )0.5(ever)-24(y)-16(t)-13(hing f)-28(ine?)]TJ /T1_1 1 Tf [( )0.5(Gastroenterol)11( )]TJ 0.018 Tc 0.637 Tw T* [(H)0.5(ep)0.5(a)0.5(t)0.5(ol)0.5( O)0.5(p)0.5(en)0.5( Ac)0.5(c)0.5(e)0.5(ss)0.5(.)]TJ /T1_0 1 Tf 9.902 0 Td [( 20)0.5(2)0.5(3;)0.5(1)0.5(4\()0.5(4)0.5(\))0.5(:)0.5(12)0.5(7\226)0.5(1)0.5(3)0.5(3.)0.5( d)-15.6(o)0.5(i)0.5(:)]TJ /Span<>> BDC 12.469 0 Td ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs -0.018 Tw [(10)0.5(.)0.5(15)0.5(4)0.5(06)0.5(/)]TJ 0 Tc 0 Tw -22.371 -1.25 Td (ghoa.2023.14.00557)Tj 0 0 0 1 k /GS1 gs 0.101 Tw T* (88.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Haug)Tj /Span<>> BDC ( )Tj EMC [(CJ, Dr)-33(a)-24(zen)]TJ /Span<>> BDC ( )Tj EMC [(JM. 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0 R 428 0 R 429 0 R 430 0 R 431 0 R 432 0 R 433 0 R 434 0 R 435 0 R 436 0 R 437 0 R 438 0 R 439 0 R 440 0 R 441 0 R 442 0 R 443 0 R 444 0 R 445 0 R 446 0 R 447 0 R 448 0 R 449 0 R 450 0 R 451 0 R 452 0 R 453 0 R 454 0 R 455 0 R] endobj 290 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\006\025\222\201\025\b\220 \211\021\001\202\215\025\b)-10(\026\021\017\021 \021\022\t\016\f\016\215\021\004 \025\b)-9.9(\026\201\025\202)10(\025 \211\021\r\016\201\026\021\017\200\t\021\026)11(\001 )]TJ 0 -1 TD [(\025\235\025\211\025\f\215\025\207 \017\021\020\017\021 \(\025\235\213\025\ \201 \t\021\026)11(\016\201\001\026)-20(\200\201\220\))]TJ 43.987 1 Td [(Issues of\022diagnosis and tr)31.1(eatment of\022acute )]TJ 3.463 -1 Td [(div)12(er)-20(ticulitis of\022th)11(e colon \(r)31(e)11(vie)11(w\))]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0.204 Tw 8 0 0 8 42.5197 731.2159 Tm [(2024;23\(2\):10\22627. \(in Russ.\). d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.33878/2073-7556-2024-23-)Tj 0 -1.25 TD (2-10-27)Tj 0 0 0 1 k /GS1 gs 0.027 Tw T* (18.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Huang)Tj /Span<>> BDC ( )Tj EMC [(S)17(S, Sung)]TJ /Span<>> BDC ( )Tj EMC [(CW, W)12(ang)]TJ /Span<>> BDC ( )Tj EMC [(HP, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. T)47(he)]TJ /Span<>> BDC ( )Tj EMC (outcomes of)Tj /Span<>> BDC ( )Tj EMC [(r)-36.9(ight-sided )]TJ 0.183 Tw -1.796 -1.25 Td [(and lef)-28(t-sided col)30(onic di)-16(ver)-22(t)-32(icul)-30.9(i)-24(t)-32(is foll)30(o)-14(wing non-oper)-32.9(a)15(t)-32(i)-16(ve man)]TJ 0 Tw (-)Tj -0.011 Tw T* [(a)-17(gement: )0.5(a)]TJ /Span<>> BDC ( )Tj EMC [(sy)-13(stema)15(t)-31.9(ic r)-24(ev)-16(iew )0.5(and me)-12(t)15(a-anal)35(y)-12.9(sis. )]TJ /T1_2 1 Tf [(W)29(orld )0.5(J Emerg )0.5(Surg.)]TJ /T1_1 1 Tf 0 Tw ( )Tj 0.023 Tw T* [(2022;17\(1\):Ar)-21.9(t. 56. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1186/s13017-022-00463-7)Tj 0 0 0 1 k /GS1 gs 0.349 Tw T* (19.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(P)40(ar)-24(k)]TJ /Span<>> BDC ( )Tj EMC [(SM, K)20(w)-13.9(on)]TJ /Span<>> BDC ( )Tj EMC [(T)25.1(S, Kim)]TJ /Span<>> BDC ( )Tj EMC [(DJ, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. P)35(r)-24(edic)-16(t)-32(ion and mana)-17(ge)]TJ 0 Tw (-)Tj 0.24 Tw -1.796 -1.25 Td (ment of)Tj /Span<>> BDC ( )Tj EMC 3.819 0 Td [(r)-24(ecur)-23.9(r)-24(ent r)-37(ight col)30(on di)-16(ver)-21.9(t)-32(icul)-31(i)-23.9(t)-32(is. )]TJ /T1_2 1 Tf [(Int J )0.5(Colorectal )0.5(Dis.)]TJ /T1_1 1 Tf 0 Tw ( )Tj 0.023 Tw -3.819 -1.25 Td [(2014;29\(11\):1355\2261360. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1007/s00384-014-2000-1)Tj 0 0 0 1 k /GS1 gs 0.012 Tw T* (20.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(P)40(ar)-24(k)]TJ /Span<>> BDC ( )Tj EMC (YY, Nam)Tj /Span<>> BDC ( )Tj EMC (S, Han)Tj /Span<>> BDC ( )Tj EMC [(JH, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. P)35(r)-24(edic)-16(t)-32(i)-16(ve f)16(a)-17(c)-16(t)17.1(or)-10(s for conser)-31.9(v)-15(a)15(t)-32(i)-16(ve )]TJ 0.087 Tw -1.796 -1.25 Td [(tr)-24(ea)15(tment f)16.1(ail)35(ur)-24(e of)]TJ /Span<>> BDC ( )Tj EMC [(r)-37(ight col)30(onic di)-16(ver)-22(t)-31.9(icul)-31(i)-24(t)-32(is)]TJ /T1_2 1 Tf [(. Ann Surg T)56(reat R)21(es.)]TJ /T1_1 1 Tf 0 Tw ( )Tj 0.023 Tw T* [(2021;100\(6\):347\226355. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.4174/astr.2021.100.6.347)Tj 0 0 0 1 k /GS1 gs 0.344 Tw T* (21.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(P)40(ar)-24(k)]TJ /Span<>> BDC ( )Tj EMC [(JH, P)40(ar)-23.9(k)]TJ /Span<>> BDC ( )Tj EMC [(HC, L)35(ee)]TJ /Span<>> BDC ( )Tj EMC [(BH. One-d)42(a)15(y ver)-9.9(sus four-d)42(a)15(y ant)-32(ibi)]TJ 0 Tw (-)Tj 0.08 Tw -1.796 -1.25 Td [(o)17(t)-32(ic tr)-24(ea)15(tment for a)-17(cute r)-37(ight col)30.1(onic uncom)10(pl)-30.9(ica)15(ted di)-16(ver)-21.9(t)-32(icul)-31(i)-23.9(t)-32(is: )]TJ 0.189 Tw T* (a)Tj /Span<>> BDC ( )Tj EMC [(r)-33(and)-16(omized cl)-31(inical tr)-36.9(ial. )]TJ /T1_2 1 Tf [(T)57(urk J Gastroenterol.)]TJ /T1_1 1 Tf ( 2019;30\(7\):605\226)Tj 0.023 Tw T* [(610. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.5152/tjg.2019.17775)Tj 0 0 0 1 k /GS1 gs 0.173 Tw T* (22.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Mueller)Tj /Span<>> BDC ( )Tj EMC [(MH, Gl)-16(a)15(tzle)]TJ /Span<>> BDC ( )Tj EMC [(J, K)-16(asp)32(ar)-24(ek)]TJ /Span<>> BDC ( )Tj EMC [(MS, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. L)35(ong-ter)-15.9(m outcome )]TJ 0.299 Tw -1.796 -1.25 Td (of)Tj /Span<>> BDC ( )Tj EMC [(conser)-32(v)-14.9(a)15(t)-32(i)-16(ve tr)-24(ea)15(tment in p)32(a)15(t)-32(ients wi)-24(t)-13(h di)-16(ver)-21.9(t)-32(icul)-31(i)-24(t)-32(is of)]TJ /Span<>> BDC ( )Tj EMC [(t)-12.9(he )]TJ 0.261 Tw T* [(sigmoid col)30.1(on)]TJ /T1_2 1 Tf (. Eur J Gastroenterol Hepatol)Tj /T1_1 1 Tf (. 2005;17\(6\):649\226654. )Tj 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1097/00042737-200506000-00010)Tj 0 0 0 1 k /GS1 gs 0.346 Tw -1.847 -1.25 Td (23.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(F)10(r)-37(ileux)]TJ /Span<>> BDC ( )Tj EMC [(P, Dubr)-23.9(ez)]TJ /Span<>> BDC ( )Tj EMC [(J, Bur)-24(d)17(y)]TJ /Span<>> BDC ( )Tj EMC [(G, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. S)-16(igmoid di)-16(ver)-22(t)-32(icul)-30.9(i)-24(t)-32(is. )]TJ 0.077 Tw -1.796 -1.25 Td [(L)35(ongi)-24(tudinal anal)35(y)-12.9(sis of)]TJ /Span<>> BDC ( )Tj EMC [(222 p)32(a)14.9(t)-31.9(ients wi)-23.9(t)-13(h a)]TJ /Span<>> BDC ( )Tj EMC [(minimal foll)30.1(o)-14(w up of)]TJ /Span<>> BDC ( )Tj EMC (5 )Tj 0.001 Tc -0.001 Tw T* [(year)-9.7(s. )]TJ /T1_2 1 Tf 0.349 Tw 2.973 0 Td (Colorectal Dis.)Tj /T1_1 1 Tf [( 2010;12\(7\):674\226680. d)-15.8(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs -0.001 Tw (10.1111/j.1463-)Tj 0 Tc 0 Tw -2.973 -1.25 Td (1318.2009.01896.x)Tj 0 0 0 1 k /GS1 gs 0.005 Tc 0.349 Tw T* (24.)Tj /Span<>> BDC ( )Tj EMC 1.815 0 Td (Daniels)Tj /Span<>> BDC ( )Tj EMC (L, \334nl\374)Tj /Span<>> BDC ( )Tj EMC [(\307, de K)25.2(or)-21.8(te)]TJ /Span<>> BDC ( )Tj EMC [(N, e)-11.8(t)]TJ /Span<>> BDC ( )Tj EMC [(al. R)-9.9(and)-15.8(omized cl)-30.8(inical)5( )]TJ 0 Tc 0.23 Tw -1.815 -1.25 Td [(tr)-37(ial of)]TJ /Span<>> BDC ( )Tj EMC [(obser)-32(v)-14.9(a)15(t)-32(ional ver)-10(sus ant)-32(ibio)17(t)-32(ic tr)-23.9(ea)15(tment for a)]TJ /Span<>> BDC ( )Tj EMC [(f)-28(ir)-9.9(st epi)]TJ 0 Tw (-)Tj 0.24 Tw T* (sode of)Tj /Span<>> BDC ( )Tj EMC [(CT-p)25(r)-31.9(oven uncom)10(pl)-31(ica)15(ted a)-17(cute di)-16(ver)-21.9(t)-32(icul)-31(i)-24(t)-31.9(is. )]TJ /T1_2 1 Tf (Br J Surg.)Tj /T1_1 1 Tf 0 Tw ( )Tj 0.023 Tw T* [(2017;104\(1\):52\22661. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1002/bjs.10309)Tj 0 0 0 1 k /GS1 gs 0.002 Tc 0.349 Tw T* (25.)Tj /Span<>> BDC ( )Tj EMC 1.803 0 Td [(P)-23.8(isanu)]TJ /Span<>> BDC ( )Tj EMC [(A, V)25.2(a)-16.9(cca)]TJ /Span<>> BDC ( )Tj EMC [(V, R)13.2(ecc)-23.7(ia)]TJ /Span<>> BDC ( )Tj EMC [(I, e)-11.8(t)]TJ /Span<>> BDC ( )Tj EMC [(al. A)-24.7(cute di)-15.8(ver)-21.8(t)-31.8(icul)-30.8(i)-23.8(t)-31.8(is in)2( )]TJ 0 Tc 0.192 Tw -1.803 -1.25 Td [(t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(young: t)-13(he)]TJ /Span<>> BDC ( )Tj EMC (same disease in a)Tj /Span<>> BDC ( )Tj EMC [(dif)-55.9(fer)-24(ent p)32(a)15(t)-31.9(ient. )]TJ /T1_2 1 Tf 0 Tw (Gastroenterol )Tj 0.023 Tw T* [(R)21(es Pract.)]TJ /T1_1 1 Tf [( 2013;2013:Ar)-22(t)-31.9(icle ID 867961. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1155/2013/867961)Tj 0 0 0 1 k /GS1 gs 0.256 Tw T* (26.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Br)-32(o)-16(chmann)]TJ /Span<>> BDC ( )Tj EMC [(ND, S)-24(chul)56(tz)]TJ /Span<>> BDC ( )Tj EMC (JK, Jakobsen)Tj /Span<>> BDC ( )Tj EMC [(GS, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Mana)-17(gement )]TJ -1.796 -1.25 Td (of)Tj /Span<>> BDC ( )Tj EMC [(a)-17(cute uncom)10.1(pl)-31(ica)15(ted di)-16(ver)-21.9(t)-32(icul)-31(i)-23.9(t)-32(is wi)-24(t)-13(hout ant)-32(ibio)17(t)-32(ics: a)]TJ /Span<>> BDC ( )Tj EMC (sin)Tj 0 Tw (-)Tj 0.33 Tw T* [(gle-centr)-23.9(e cohor)-22(t stud)17(y. )]TJ /T1_2 1 Tf (Colorectal Dis.)Tj /T1_1 1 Tf ( 2016;18\(11\):1101\2261107. )Tj 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1111/codi.13313)Tj 0 0 0 1 k /GS1 gs -0.046 Tw -1.847 -1.25 Td (27.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(T)45(o)-16(or)-24(envl)-30.9(ie)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(BR, Bakk)10(er)]TJ /Span<>> BDC ( )Tj EMC 9.094 0 Td [(RF, Br)-24(esl)-15.9(au)]TJ /Span<>> BDC ( )Tj EMC [(P)35(J, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. )0.5(Col)30(onic di)-16(ver)-21.9(t)-32(icul)-31(i)-24(t)-32(is: )]TJ 0.068 Tw -10.89 -1.25 Td (a)Tj /Span<>> BDC ( )Tj EMC [(p)25(r)-32(ospec)-16(t)-32(i)-15.9(ve anal)35(y)-13(sis of)]TJ /Span<>> BDC ( )Tj EMC [(dia)-17(gnost)-31.9(ic a)-17(ccur)-33(a)-17(cy and cl)-31(inical dec)-24(ision-)]TJ 0 Tw T* [(mak)-16(ing. )]TJ /T1_2 1 Tf 0.188 Tw 3.662 0 Td (Colorectal Dis.)Tj /T1_1 1 Tf [( 2010;12\(3\):179\226186. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1111/j.1463-)Tj -3.662 -1.25 Td (1318.2009.01807.x)Tj 0 0 0 1 k /GS1 gs 0.059 Tw T* (28.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(K)25(echa)-17(gias)]TJ /Span<>> BDC ( )Tj EMC [(A, R)-10(aut)-32(io)]TJ /Span<>> BDC ( )Tj EMC [(T, K)25(echa)-17(gias)]TJ /Span<>> BDC ( )Tj EMC [(G, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. T)47(he)]TJ /Span<>> BDC ( )Tj EMC [(r)-32(ole of)]TJ /Span<>> BDC ( )Tj EMC [(C-r)-23.9(ea)-17(c)-16(t)-32(i)-16(ve )]TJ 0.003 Tw -1.796 -1.25 Td [(p)25(r)-32(o)17(tein in t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(p)25(r)-24(edic)-16(t)-32(ion of)]TJ /Span<>> BDC ( )Tj EMC [(t)-13(he cl)-31(inical sever)-37(i)-24(t)-9.9(y of)]TJ /Span<>> BDC ( )Tj EMC [(a)-17(cute di)-16(ver)-21.9(t)-32(icul)-31(i)]TJ 0 Tw (-)Tj T* [(t)-32(is. )]TJ /T1_2 1 Tf 0.023 Tw 1.604 0 Td (Am Surg.)Tj /T1_1 1 Tf ( 2014;80\(4\):391\226395. PMID: 24887671)Tj 0.031 Tw -1.604 -1.25 Td (29.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(M\344k)10(el\344)]TJ /Span<>> BDC ( )Tj EMC [(JT, Kl)-30.9(intr)-22(up)]TJ /Span<>> BDC ( )Tj EMC [(K, T)40(ak)-17(al)-16(a)]TJ /Span<>> BDC ( )Tj EMC [(H, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. T)47(he)]TJ /Span<>> BDC ( )Tj EMC [(r)-32(ole of)]TJ /Span<>> BDC ( )Tj EMC [(C-r)-24(ea)-17(c)-16(t)-31.9(i)-16(ve p)25(r)-32(o)]TJ 0 Tw (-)Tj 0.056 Tw -1.796 -1.25 Td [(tein in p)25(r)-24(edic)-16(t)-32(ion of)]TJ /Span<>> BDC ( )Tj EMC [(t)-13(he sever)-36.9(i)-24(t)-10(y of)]TJ /Span<>> BDC ( )Tj EMC [(a)-17(cute di)-16(ver)-22(t)-32(icul)-30.9(i)-24(t)-32(is in an)]TJ /Span<>> BDC ( )Tj EMC (emer)Tj 0 Tw 27.286 0 Td (-)Tj 0.036 Tw -27.286 -1.25 Td [(gency uni)-24(t. )]TJ /T1_2 1 Tf (Scand J Gastroenterol)Tj /T1_1 1 Tf [(. 2015;50\(5\):536\226541. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.310)Tj T* (9/00365521.2014.1003398)Tj 0 0 0 1 k /GS1 gs -0.019 Tw T* (30.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(K)25(echa)-17(gias)]TJ /Span<>> BDC ( )Tj EMC [(A, S)-16(of)-28(ianidis)]TJ /Span<>> BDC ( )Tj EMC [(A, Z)25.1(o)-16(gr)-33(afos)]TJ /Span<>> BDC ( )Tj EMC [(G, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Inde)-18(x C-r)-23.9(ea)-17(c)-16(t)-32(i)-16(ve p)25(r)-32(o)]TJ 0 Tw (-)Tj 0.039 Tw -1.796 -1.25 Td [(tein p)25(r)-24(edic)-16(ts incr)-24(eased sever)-36.9(i)-24(t)-9.9(y in a)-17(cute sigmoid di)-16(ver)-22(t)-32(icul)-30.9(i)-24(t)-32(is. )]TJ /T1_2 1 Tf 0 Tw (Ther )Tj 0.023 Tw T* (Clin Risk Manag.)Tj /T1_1 1 Tf [( 2018;14:1847\2261853. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw [(10.2147/T)35(CRM.S160113)]TJ 0 0 0 1 k /GS1 gs -0.03 Tw T* (31.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Gewur)-23.9(z)]TJ /Span<>> BDC ( )Tj EMC [(H, M)-23.9(old)]TJ /Span<>> BDC ( )Tj EMC [(C, S)-16(iegel)]TJ /Span<>> BDC ( )Tj EMC [(J, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. C-r)-24(ea)-17(c)-16(t)-32(i)-15.9(ve p)25(r)-32(o)17(tein and t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(a)-17(cute )]TJ 0.023 Tw -1.796 -1.25 Td [(phase r)-23.9(esponse. )]TJ /T1_2 1 Tf [(Adv Inter)-13.9(n Med. )]TJ /T1_1 1 Tf (1982;27:345\226372. PMID: 7041546)Tj 0.192 Tw T* (32.Andeweg)Tj /Span<>> BDC ( )Tj EMC [(CS, W)22(egd)42(am)]TJ /Span<>> BDC ( )Tj EMC [(J)15(A, G)20(r)-31.9(oenew)-14(oud)]TJ /Span<>> BDC ( )Tj EMC [(J, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. T)45(o)-14(w)-12(ar)-23.9(d an)]TJ /Span<>> BDC ( )Tj EMC [(ev)-16(i)]TJ 0 Tw (-)Tj 0.198 Tw T* [(dence-based step-up app)25(r)-32(oa)-17(ch in dia)-17(gnosing di)-16(ver)-21.9(t)-32(icul)-31(i)-23.9(t)-32(is. )]TJ /T1_2 1 Tf 0 Tw (Scand )Tj 0.223 Tw T* [(J )0.5(Gastroenterol)]TJ /T1_1 1 Tf [(. )0.5(2014;49\(7\):775\226784. )0.6(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw 18.103 0 Td (10.3109/00365521.201)Tj -18.103 -1.25 Td (4.908475)Tj 0 0 0 1 k /GS1 gs -0.052 Tw T* (33.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(L)-32(am\351r)-36.9(is)]TJ /Span<>> BDC ( )Tj EMC [(W, v)-14.9(an R)-9.9(anden)]TJ /Span<>> BDC ( )Tj EMC [(A, Bip)32.1(a)15(t)]TJ /Span<>> BDC ( )Tj EMC [(S, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. G)20(r)-32.9(aded com)10(p)25(r)-24(ession ul)56(tr)-32.9(a)]TJ 0 Tw (-)Tj 0.065 Tw -1.796 -1.25 Td [(sono)-16(gr)-33(aphy and com)10(puted t)17(omo)-16(gr)-33(aphy in a)-17(cute col)30(onic di)-16(ver)-22(t)-31.9(icul)-31(i)]TJ 0 Tw (-)Tj 0.133 Tw T* [(t)-32(is: me)-11.9(t)15(a-anal)35(y)-13(sis of)]TJ /Span<>> BDC ( )Tj EMC [(test )0.5(a)-17(ccur)-33(a)-17(cy. )]TJ /T1_2 1 Tf 14.965 0 Td [(Eur R)20(adiol.)]TJ /T1_1 1 Tf ( 2008;18\(11\):2498\226)Tj 0.023 Tw -14.965 -1.25 Td [(2511. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1007/s00330-008-1018-6)Tj 0 0 0 1 k /GS1 gs 0.183 Tw T* (34.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Ma)-24(z)-24(zei)]TJ /Span<>> BDC ( )Tj EMC [(MA, Ciof)-56(f)-28(iSqui)-23.9(t)-32(ier)-37(i)]TJ /Span<>> BDC ( )Tj EMC [(N, Guer)-24(r)-36.9(ini)]TJ /Span<>> BDC ( )Tj EMC [(S, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. S)-16(igmoid di)-16(ver)]TJ 0 Tw 25.49 0 Td (-)Tj 0.299 Tw -27.286 -1.25 Td [(t)-32(icul)-31(i)-23.9(t)-32(is: US f)-28(indings. )]TJ /T1_2 1 Tf [(Cr)-37(it Ultrasound)]TJ /Span<>> BDC ( )Tj EMC (J.)Tj /T1_1 1 Tf ( 2013;5:Suppl 1. S1-S5. )Tj 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1186/2036-7902-5-S1-S1)Tj 0 0 0 1 k /GS1 gs 0.012 Tc 0.445 Tw -1.847 -1.25 Td (35.)Tj /Span<>> BDC ( )Tj EMC 1.844 0 Td [(P)19.9(uyl)-16.1(aer)-22(t)]TJ /Span<>> BDC ( )Tj EMC [(JB. Ul)55.9(tr)-33.1(asound of)]TJ /Span<>> BDC ( )Tj EMC [(col)30(on di)-16(ver)-22(t)-32.1(icul)-31.1(i)-24(t)-32(is. )]TJ /T1_2 1 Tf (Dig Dis.)Tj /T1_1 1 Tf 0 Tc 0 Tw 25.794 0 Td ( )Tj 0.023 Tw -27.638 -1.25 Td [(2012;30\(1\):56\22659. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1159/000336620)Tj 0 0 0 1 k /GS1 gs 0.142 Tw T* (36.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Andeweg)Tj /Span<>> BDC ( )Tj EMC [(CS, W)22(egd)42(am)]TJ /Span<>> BDC ( )Tj EMC [(J)15(A, G)20(r)-32(oenew)-13.9(oud)]TJ /Span<>> BDC ( )Tj EMC [(J, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. T)45(o)-14(w)-12(ar)-23.9(d an)]TJ /Span<>> BDC ( )Tj EMC [(ev)-15.9(i)]TJ 0 Tw (-)Tj 0.198 Tw -1.796 -1.25 Td [(dence-based step-up app)25(r)-32(oa)-17(ch in dia)-17(gnosing di)-16(ver)-21.9(t)-32(icul)-30.9(i)-24(t)-32(is. )]TJ /T1_2 1 Tf 0 Tw (Scand )Tj 0.223 Tw 29.055 81.25 Td [(J )0.5(Gastroenterol)]TJ /T1_1 1 Tf [(. )0.5(2014;49\(7\):775\226784. )0.6(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw 18.103 0 Td (10.3109/00365521.201)Tj -18.103 -1.25 Td (4.908475)Tj 0 0 0 1 k /GS1 gs 0.281 Tw T* (37.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(L)-32(am\351r)-36.9(is)]TJ /Span<>> BDC ( )Tj EMC [(W, )0.5(v)-15(an R)-9.9(anden)]TJ /Span<>> BDC ( )Tj EMC [(A, )0.5(v)-15(an )0.5(Es)]TJ /Span<>> BDC ( )Tj EMC [(HW, )0.5(e)-12(t)]TJ /Span<>> BDC ( )Tj EMC 18.487 0 Td [(al. )0.5(OPTIMA )0.5(stud)17(y )]TJ 0.267 Tw -20.283 -1.25 Td [(gr)-32(oup: ima)-17(ging str)-33(a)15(tegies for de)-12(tec)-16(t)-32(ion of)]TJ /Span<>> BDC ( )Tj EMC [(ur)-32(gent condi)-24(t)-32(ions in )]TJ -0.013 Tw T* [(p)32(a)15(t)-32(ients wi)-24(t)-13(h a)-17(cute abd)-16(ominal p)32(ain: dia)-17(gnost)-31.9(ic a)-17(ccur)-32.9(a)-17(cy stud)17(y. )]TJ /T1_2 1 Tf 0 Tw (BMJ.)Tj /T1_1 1 Tf ( )Tj 0.023 Tw T* [(2009;338:Ar)-21.9(t. b2431. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1136/bmj.b2431)Tj 0 0 0 1 k /GS1 gs 0.186 Tw T* (38.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Halpenny)Tj /Span<>> BDC ( )Tj EMC (DF, McNeil)Tj /Span<>> BDC ( )Tj EMC [(G, Sno)-14(w)]TJ /Span<>> BDC ( )Tj EMC [(A, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. P)35(r)-32(ospec)-16(t)-31.9(i)-16(ve ev)-15(al)35(ua)15(t)-32(ion )]TJ 0.24 Tw -1.796 -1.25 Td (of)Tj /Span<>> BDC ( )Tj EMC [(t)-13(he v)-15(al)35(ue of)]TJ /Span<>> BDC ( )Tj EMC [(ma)-17(gne)-11.9(t)-32(ic r)-23.9(esonance ima)-16.9(ging in suspec)-16(ted a)-17(cute )]TJ 0.3 Tw T* [(sigmoid di)-16(ver)-21.9(t)-32(icul)-31(i)-24(t)-32(is. )]TJ /T1_2 1 Tf [(Dis Colon )0.5(R)20.9(ectum.)]TJ /T1_1 1 Tf ( 2009;52\(5\):1030\2261031. )Tj 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1007/DCR.0b013e3181a51126)Tj 0 0 0 1 k /GS1 gs 0.238 Tw -1.847 -1.25 Td (39.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(P)30(eer)-23.9(y)]TJ /Span<>> BDC ( )Tj EMC [(AF, S)-16(hauk)-17(a)15(t)]TJ /Span<>> BDC ( )Tj EMC [(A, )0.5(S)15(tr)-33(a)15(te)]TJ /Span<>> BDC ( )Tj EMC [(LL. )0.5(A)16(GA )0.5(cl)-31(inical p)25(r)-32.9(a)-17(c)-16(t)-32(ice upd)42(a)15(te )]TJ 0.259 Tw -1.796 -1.25 Td [(on medical mana)-17(gement of)]TJ /Span<>> BDC ( )Tj EMC [(col)30(onic di)-16(ver)-21.9(t)-32(icul)-31(i)-24(t)-31.9(is: e)-18(xper)-22(t r)-23.9(ev)-16(iew. )]TJ /T1_2 1 Tf 0.023 Tc -0.023 Tw T* [(G)0.5(a)0.5(s)0.5(t)0.5(r)0.5(o)0.5(e)0.5(n)0.5(t)0.5(e)0.5(r)0.5(o)0.5(l)0.5(o)0.5(g)0.5(y)]TJ /T1_1 1 Tf 0.811 Tw 7.002 0 Td [(.)0.5( )0.5(2)0.5(0)0.5(2)0.5(1)0.5(;)0.5(1)0.5(6)0.5(0)0.5(\()0.5(\))0.5(:)0.5(9)0.5(0)0.5(6\226)0.5(9)0.5(1)0.5(1)0.5(.)0.5( )0.5(d)-15.5(o)0.5(i)0.5(:)]TJ /Span<>> BDC 13.259 0 Td ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs -0.023 Tw 1.066 0 Td [(1)0.5(0)0.5(.)0.5(1)0.5(0)0.5(5)0.5(3)0.5(/)0.5(j)0.5(.)0.5(ga)0.5(s)]TJ 0 Tc 0 Tw 5.958 0 Td (-)Tj -27.286 -1.25 Td [(tr)-32(o.2020.09.059)]TJ 0 0 0 1 k /GS1 gs 0.011 Tc 0.416 Tw T* (40.)Tj /Span<>> BDC ( )Tj EMC 1.841 0 Td [(S)-24.2(chul)55.8(tz)]TJ /Span<>> BDC ( )Tj EMC [(JK, A)-24.2(zhar)]TJ /Span<>> BDC ( )Tj EMC [(N, Bind)41.8(a)]TJ /Span<>> BDC ( )Tj EMC [(GA, e)-12.2(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Eur)-32.2(opean S)-16.2(o)-16.2(c)-24.2(ie)-12.2(t)-10.2(y)11( )]TJ 0 Tc 0.31 Tw -1.841 -1.25 Td (of)Tj /Span<>> BDC ( )Tj EMC [(Col)30(op)25(r)-32(o)-16(c)-16(t)17.1(ol)30(o)-16(g)16(y: guidel)-31(ines for t)-12.9(he)]TJ /Span<>> BDC ( )Tj EMC [(mana)-17(gement of)]TJ /Span<>> BDC ( )Tj EMC [(di)-16(ver)-22(t)-31.9(icu)]TJ 0 Tw (-)Tj 0.218 Tw T* [(l)-16(ar disease of)]TJ /Span<>> BDC ( )Tj EMC [(t)-13(he col)30(on. )]TJ /T1_2 1 Tf (Colorectal Dis.)Tj /T1_1 1 Tf ( 2020; 22, Suppl 2: 5-28. )Tj 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1111/codi.15140)Tj 0 0 0 1 k /GS1 gs -0.044 Tw -1.847 -1.25 Td (41.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Hall)Tj /Span<>> BDC ( )Tj EMC 1.781 0 Td [(J, Har)-23.9(diman)]TJ /Span<>> BDC ( )Tj EMC [(K, )0.5(L)35(ee)]TJ /Span<>> BDC ( )Tj EMC [(S, )0.5(e)-12(t)]TJ /Span<>> BDC ( )Tj EMC 9.187 0 Td [(al. )0.5(T)47(he)]TJ /Span<>> BDC ( )Tj EMC [(Amer)-36.9(ican S)-16(o)-16(c)-23.9(ie)-12(t)-10(y of)]TJ /Span<>> BDC ( )Tj EMC 10.989 0 Td [(Col)30(on and )]TJ -0.026 Tw -23.752 -1.25 Td [(R)13(ec)-16(t)15(al Sur)-31.9(geons cl)-31(inical p)25.1(r)-33(a)-17(c)-16(t)-32(ice guidel)-30.9(ines for t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(tr)-24(ea)15(tment of)]TJ /Span<>> BDC ( )Tj EMC [(lef)-27.9(t-)]TJ 0.066 Tw T* [(sided col)30(onic di)-16(ver)-22(t)-32(icul)-30.9(i)-24(t)-32(is. )]TJ /T1_2 1 Tf [(Dis Colon R)21(ectum.)]TJ /T1_1 1 Tf ( 2020;63\(6\):728\226747. )Tj 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1097/DCR.0000000000001679)Tj 0 0 0 1 k /GS1 gs -0.027 Tw -1.847 -1.25 Td (42.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Balk)Tj /Span<>> BDC ( )Tj EMC 1.92 0 Td [(EM, )0.6(A)15(d)42(am)]TJ /Span<>> BDC ( )Tj EMC 3.927 0 Td [(GP, )0.6(Bhuma)]TJ /Span<>> BDC ( )Tj EMC 4.411 0 Td [(MR, )0.6(e)-12(t)]TJ /Span<>> BDC ( )Tj EMC 2.621 0 Td [(al. )0.6(Dia)-17(gnost)-32(ic )0.6(ima)-17(ging )0.5(and )0.6(med)]TJ 0 Tw (-)Tj 0.007 Tw -14.675 -1.25 Td [(ical mana)-17(gement of)]TJ /Span<>> BDC ( )Tj EMC [(a)-17(cute lef)-28(t-sided col)30(onic di)-15.9(ver)-22(t)-32(icul)-30.9(i)-24(t)-32(is: a)]TJ /Span<>> BDC ( )Tj EMC [(sy)-13(stem)]TJ 0 Tw (-)Tj 0.121 Tw T* [(a)15(t)-32(ic )0.6(r)-24(ev)-16(iew. )]TJ /T1_2 1 Tf 5.193 0 Td [(Ann )0.5(Inter)-14(n )0.5(Med.)]TJ /T1_1 1 Tf [( )0.5(2022; )0.6(175\(.\): )0.5(379-387. )0.6(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw 18.706 0 Td (10.7326/)Tj -23.899 -1.25 Td (M21-1645)Tj 0 0 0 1 k /GS1 gs 0.264 Tw T* (43.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Kr)-22(uis)]TJ /Span<>> BDC ( )Tj EMC [(W, Ger)-16(mer)]TJ /Span<>> BDC ( )Tj EMC (CT, B\366hm)Tj /Span<>> BDC ( )Tj EMC [(S, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Ger)-15.9(man guidel)-31(ine di)-16(ver)]TJ 0 Tw 25.49 0 Td (-)Tj 0.012 Tc 0.455 Tw -27.286 -1.25 Td [(t)-32.3(icul)-16.3(ar disease/di)-16.3(ver)-22.3(t)-32.3(icul)-31.3(i)-24.3(t)-32.3(is: P)39.6(ar)-22.3(t II: conser)-32.3(v)-15.3(a)14.7(t)-32.3(i)-16.3(ve, inter)-32.4(ven)]TJ 0 Tc 0 Tw (-)Tj 0.166 Tw T* [(t)-32(ional and sur)-32(gical mana)-17(gement. )]TJ /T1_2 1 Tf [(U)22(nited European Gastroenterol)]TJ /Span<>> BDC ( )Tj EMC (J)Tj /T1_1 1 Tf 0 Tw (. )Tj 0.023 Tw T* [(2022;10\(9\):940\226957. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1002/ueg2.12308)Tj 0 0 0 1 k /GS1 gs 0.209 Tw T* (44.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(R)-10(ajpur)-23.9(k)-17(ar)]TJ /Span<>> BDC ( )Tj EMC [(P, L)35(ungr)-24(en)]TJ /Span<>> BDC ( )Tj EMC [(MP. T)47(he)]TJ /Span<>> BDC ( )Tj EMC [(cur)-24(r)-24(ent and futur)-23.9(e st)15(a)15(te of)]TJ /Span<>> BDC ( )Tj EMC (AI )Tj 0 Tw -1.796 -1.25 Td [(inter)-23.9(p)25(r)-24(e)-12(t)15(a)15(t)-32(ion of)]TJ /Span<>> BDC ( )Tj EMC [(medical ima)-17(ges. )]TJ /T1_2 1 Tf [(N Eng)13(l J Med.)]TJ /T1_1 1 Tf ( 2023;388\(21\):1981\226)Tj 0.023 Tw T* [(1990. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw [(10.1056/NEJMr)-33(a2301725)]TJ 0 0 0 1 k /GS1 gs 0.005 Tc 0.349 Tw T* (45.)Tj /Span<>> BDC ( )Tj EMC 1.815 0 Td (Daniels)Tj /Span<>> BDC ( )Tj EMC (L, \334nl\374)Tj /Span<>> BDC ( )Tj EMC [(\307, de K)25.2(or)-21.8(te)]TJ /Span<>> BDC ( )Tj EMC [(N, e)-11.9(t)]TJ /Span<>> BDC ( )Tj EMC [(al. R)-9.9(and)-15.8(omized cl)-30.8(inical)5( )]TJ 0 Tc 0.23 Tw -1.815 -1.25 Td [(tr)-37(ial of)]TJ /Span<>> BDC ( )Tj EMC [(obser)-32(v)-14.9(a)15(t)-32(ional ver)-10(sus ant)-32(ibio)17(t)-32(ic tr)-23.9(ea)15(tment for a)]TJ /Span<>> BDC ( )Tj EMC [(f)-28(ir)-9.9(st epi)]TJ 0 Tw (-)Tj 0.24 Tw T* (sode of)Tj /Span<>> BDC ( )Tj EMC [(CT-p)25.1(r)-32(oven uncom)10(pl)-31(ica)15(ted a)-17(cute di)-16(ver)-21.9(t)-32(icul)-31(i)-24(t)-31.9(is. )]TJ /T1_2 1 Tf (Br J Surg.)Tj /T1_1 1 Tf 0 Tw ( )Tj 0.023 Tw T* [(2017;104\(1\):52\22661. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1002/bjs.10309)Tj 0 0 0 1 k /GS1 gs 0.139 Tw T* (46.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Sar)-37(in)]TJ /Span<>> BDC ( )Tj EMC [(S, Boul)30.1(os)]TJ /Span<>> BDC ( )Tj EMC [(PB. L)35(ong-ter)-16(m outcome of)]TJ /Span<>> BDC ( )Tj EMC [(p)32(a)15(t)-32(ients p)25(r)-24(esent)-32(ing )]TJ -0.023 Tw -1.796 -1.25 Td [(wi)-24(t)-12.9(h a)-17(cute com)10(pl)-31(ica)15.1(t)-32(ions of)]TJ /Span<>> BDC ( )Tj EMC [(di)-16(ver)-21.9(t)-32(icul)-16(ar disease. )]TJ /T1_2 1 Tf [(Ann R CollSurg Eng)13(l.)]TJ /T1_1 1 Tf 0 Tw ( )Tj 0.023 Tw T* (1994;76\(2\):117\226120. PMID: 8154816)Tj 0.35 Tw T* (47.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Hjer)-15.1(n)]TJ /Span<>> BDC ( )Tj EMC 2.789 0 Td [(F, )0.5(Josephson)]TJ /Span<>> BDC ( )Tj EMC 6.013 0 Td [(T, )0.5(Al)55.9(tman)]TJ /Span<>> BDC ( )Tj EMC [(D, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC 7.361 0 Td [(al. )0.5(Conser)-32.1(v)-15(a)14.9(t)-32(i)-16(ve )0.5(tr)-24(ea)14.9(t)]TJ 0 Tw (-)Tj 0.013 Tc 0.473 Tw -17.958 -1.25 Td (ment of)Tj /Span<>> BDC ( )Tj EMC [(a)-16.9(cute col)30.2(onic di)-15.9(ver)-21.9(t)-31.8(icul)-30.8(i)-23.9(t)-31.8(is: ar)-23.8(e ant)-31.8(ibio)17.1(t)-31.8(ics al)16.2(w)-11.9(a)15.2(y)-12.8(s)13( )]TJ 0.031 Tc -0.031 Tw T* [(mand)41.7(a)14.7(t)16.7(or)-24.3(y? )]TJ /T1_2 1 Tf 1.12 Tw 6.35 0 Td [(Scand )0.5(J )0.5(Gastroenterol.)]TJ /T1_1 1 Tf [( )0.5(2007;42\(1\):41\22647.)31( )]TJ 0 Tc 0 Tw -6.35 -1.25 Td [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1080/00365520600825257)Tj 0 0 0 1 k /GS1 gs 0.344 Tw -1.847 -1.25 Td (48.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(P)30(eer)-23.9(y)]TJ /Span<>> BDC ( )Tj EMC [(AF. )0.5(It\246s )0.5(a)-17(c)-16(tuall)35.1(y )0.5(a)]TJ /Span<>> BDC ( )Tj EMC [(l)-31(i)-23.9(t)-30(tle com)10.1(pl)-31(ica)15(ted: )0.5(ant)-32(ibio)17(t)-32(ics )0.5(for )]TJ 0.052 Tw -1.796 -1.25 Td [(uncom)10(pl)-31(ica)15.1(ted )0.5(di)-16(ver)-21.9(t)-32(icul)-31(i)-23.9(t)-32(is)]TJ /T1_2 1 Tf [(. )0.6(Am )0.5(J )0.6(Gastroenterol.)]TJ /T1_1 1 Tf [( )0.6(2018;113\(7\):949\226)]TJ 0.023 Tw T* [(950. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1038/s41395-018-0101-0)Tj 0 0 0 1 k /GS1 gs 0.26 Tw T* (49.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Mege)Tj /Span<>> BDC ( )Tj EMC [(D, Y)30(eo)]TJ /Span<>> BDC ( )Tj EMC [(H. Me)-11.9(t)15(a-anal)35(y)-13(ses of)]TJ /Span<>> BDC ( )Tj EMC [(cur)-23.9(r)-24(ent str)-32.9(a)15(tegies t)17(o)]TJ /Span<>> BDC ( )Tj EMC [(tr)-24(ea)15(t )]TJ 0.3 Tw -1.796 -1.25 Td [(uncom)10(pl)-31(ica)15.1(ted di)-16(ver)-21.9(t)-32(icul)-31(i)-23.9(t)-32(is. )]TJ /T1_2 1 Tf [(Dis Colon R)21(ectum.)]TJ /T1_1 1 Tf ( 2019;62\(3\):371\226)Tj 0.023 Tw T* [(378. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1097/DCR.0000000000001323)Tj 0 0 0 1 k /GS1 gs 0.109 Tw T* (50.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Biond)-16(o)]TJ /Span<>> BDC ( )Tj EMC [(S, Gold)42(a)]TJ /Span<>> BDC ( )Tj EMC [(T, Kr)-24(eisler)]TJ /Span<>> BDC ( )Tj EMC [(E, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. 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[(\217)5.5(\036)-19(\007)-20.1(\026\022)-32.6(\021)-17.7(\017)1.5(\030)-11.8(\024)-4.4(\r)-8.8(\026\027)1.8(\017)-8.7(\036)6.5(:)]TJ /T1_2 1 Tf -0.024 Tc 0.024 Tw [( \202)28.8(\022)-19.4(\006)-20(\016)-24.9(\033)-27.3(\025)-14.7(\023\027)-15(\037)-22.2(\035)-20(\034)-14.4(\036)]TJ /Span<>> BDC 13.216 0 Td ( )Tj EMC [(.)-3.9(\214)-4.6(.)]TJ /T1_1 1 Tf 0 Tc 0.023 Tw 10.028 29.227 Td (AUTHORS CONTRIBUTION)Tj /T1_0 1 Tf 0.932 Tw T* [(C)-6.5(o)-5.8(l)-19(l)-14.3(e)-9.4(c)-32.5(t)-37.3(i)3.2(o)0.8(n a)2.4(n)-4.6(d p)-3.8(r)-6(o)-7(ce)-13.3(s)-12.8(s)-16.6(i)7.1(n)-1.9(g o)-2.2(f)]TJ /Span<>> BDC ( )Tj EMC [(t)-16.7(h)-5.3(e m)1.8(a)-8.4(t)-15.2(e)-2.1(r)-48(i)5.2(a)-1.5(l)-44.6(s)2.2(:)]TJ /T1_2 1 Tf 0 Tw ( )Tj T* [(S)15.3(h)4.8(a)-0.8(m)5.8(i)7.4(l)]TJ /Span<>> BDC ( )Tj EMC [(V)53.2(.)]TJ /Span<>> BDC ( )Tj EMC [(T)-2.7(i)8.4(m)-1.1(e)-1.6(r)-3(b)2.9(u)2.8(l)3.3(a)-4.9(t)1.4(o)-0.6(v)33.6(, A)9.6(i)5.9(g)3.7(u)2.8(l)]TJ /Span<>> BDC ( )Tj EMC [(R)-2.5(.)]TJ /Span<>> BDC ( )Tj EMC [(G)1.5(a)3.8(f)-3.9(ar)2.4(o)-0.6(v)10.8(a)]TJ /T1_0 1 Tf T* [(W)3.1(r)-48(i)-6(t)-37.4(i)7.1(n)-1.9(g o)-2.2(f)]TJ /Span<>> BDC ( )Tj EMC [(t)-16.7(h)-5.3(e t)-15.2(e)-23.9(x)-36(t)-20(:)]TJ /T1_2 1 Tf -0.003 Tc 0.003 Tw [( S)12.3(h)1.8(a)-3.8(m)2.8(i)4.4(l)]TJ /Span<>> BDC 10.794 0 Td ( )Tj EMC [(V)50.1(.)]TJ /Span<>> BDC 0.955 0 Td ( )Tj EMC [(T)-5.7(i)5.4(m)-4.1(e)-4.7(r)-6(bula)-7.9(t)-1.6(o)-3.6(v)]TJ /T1_0 1 Tf 0.006 Tc -0.006 Tw -11.749 -1.218 Td [(E)11.6(dit)-31.4(i)13.1(n)4.1(g)15(:)]TJ /T1_2 1 Tf -0.003 Tc 0.003 Tw 3.238 0 Td [( V)-8.5(i)4.4(l)]TJ /Span<>> BDC 1.224 0 Td ( )Tj EMC [(M)2.4(.)]TJ /Span<>> BDC 1.172 0 Td ( )Tj EMC [(T)-5.7(i)5.4(m)-4.1(e)-4.7(r)-6(bula)-7.9(t)-1.6(o)-3.6(v)]TJ /T1_1 1 Tf 0 Tc 0.023 Tw -5.633 -2.436 Td (\255\026\036\031\036\025\034\226 \017\223 \032\026\020\017\022\032\225 \(\ ORCID\))Tj /T1_0 1 Tf 0.272 Tw T* [(\230\017\n\036\030\002\031\035\026\021\024\r )0.6(\221\026\n\017\035\034 )0.5(\200\017\035\036\r\017\004)]TJ /Span<>> BDC ( )Tj EMC 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ORCID)Tj /Span<>> BDC ( )Tj EMC (0000-)Tj 0 Tw ( )Tj 0 -1.218 TD (0003-2874-7213)Tj 0.02 Tc 0.119 Tw T* (\230\017\n\036\030\002\031\035\026\021\024\r \200\017\035\034 \204\026\n\ \017\035\024\r\017\004)Tj /Span<>> BDC ( )Tj EMC (\227 \007.\n.\027., \023\030\024\235\036\f)Tj 0 Tc 0 Tw (-)Tj 0.02 Tc 0.304 Tw T* (\f\024\030, \004\035\036\027-\022\024\030\030. \217\202\203, \026\r\036\ \007\031\033\013\017\005 \022\026\235\036\007\030\024\005 \b\017)Tj 0 Tc 0 Tw (-)Tj 0.02 Tc 0.16 Tw T* (\030\031\030\020\017\017 \017)Tj /Span<>> BDC ( )Tj EMC [(\220\027\007\024\f\022\024\023\017\017, \205\206\207\210\211 \200\210 \207\ \206\204\211 \204\017\027\007\030\026\r\026)20( )]TJ 0 Tw T* (\217\024\f\f\017\017, \020.)Tj /Span<>> BDC ( )Tj EMC (\211\235\026; ORCID)Tj /Span<>> BDC ( )Tj EMC (0000-0003-1696-3146)Tj /T1_1 1 Tf 0 Tc 0.023 Tw 0 -2.436 TD (INFORMATION ABOUT THE)Tj /Span<>> BDC ( )Tj EMC (AUTHORS \(ORCID\))Tj /T1_0 1 Tf 0 Tw 0 -1.218 TD [(S)-16(hamil V. T)35.1(imer)-24(bul)-16(a)15(t)17.1(ov)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0002-4832-6363)Tj T* [(Aigul R. Gaf)16.1(ar)-32(ov)-15(a)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0003-2874-7213)Tj T* [(V)-15(il M. T)35.1(imer)-24(bul)-16(a)15(t)17(ov)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0003-1696-3146)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 70.936 396.0239 Tm [(\r\031\024\034\033)48(\026)45(\024)-10(\223\033)48(\026/REFERENCES)]TJ 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.013 Tc 0.464 Tw 8 0 0 8 70.8661 383.1892 Tm (1.)Tj /Span<>> BDC ( )Tj EMC 1.334 0 Td [(W)22.4(eizman)]TJ /Span<>> BDC ( )Tj EMC [(A)36.4(V, Nguyen)]TJ /Span<>> BDC ( )Tj EMC [(GC. Di)-15.6(ver)-21.6(t)-31.6(icul)-15.6(ar disease: epidemiol)]TJ 0 Tc 0 Tw (-)Tj 0.011 Tc 0.392 Tw -1.334 -1.25 Td [(o)-15.5(g)16.4(y)0.5( a)0.5(n)0.5(d)0.5( m)0.5(an)0.5(a)-16.5(g)0.5(em)0.5(e)0.5(nt)0.5(.)0.5( )]TJ /T1_2 1 Tf [(C)0.5(a)0.5(n)0.5( J)0.5( G)0.5(a)0.5(st)0.5(r)0.5(o)0.5(e)0.5(nt)0.5(e)0.5(r)0.5(ol)0.5(.)]TJ /T1_0 1 Tf 19.385 0 Td [( 2)0.5(0)0.5(11)0.5(;)0.5(2)0.5(5:)0.5(3)0.5(85)0.5(\226)0.5(38)0.5(9)0.5(.)11( )]TJ 0 Tc 0 Tw -19.385 -1.25 Td [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1155/2011/795241)Tj 0 0 0 1 k /GS1 gs 0.308 Tw -1.847 -1.25 Td (2.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(S)-24(choe)-12(tz)]TJ /Span<>> BDC ( )Tj EMC 3.733 0 Td [(DJ. )0.5(Di)-16(ver)-21.9(t)-32(icul)-16(ar )0.5(disease )0.5(of)]TJ /Span<>> BDC ( )Tj EMC 12.004 0 Td [(t)-13(he )0.5(col)30(on: )0.5(a)]TJ /Span<>> BDC ( )Tj EMC 5.917 0 Td [(centur)-23.9(y-old )]TJ 0.001 Tc -0.001 Tw -22.95 -1.25 Td [(p)25.3(r)-31.7(oblem. )]TJ /T1_2 1 Tf 0.349 Tw 4.156 0 Td [(Dis Colon R)21.3(ectum.)]TJ /T1_0 1 Tf [( 1999;42\(6\):703\226709. d)-15.7(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs -0.001 Tw (10.1007/)Tj 0 Tc 0 Tw -4.156 -1.25 Td (BF02236925)Tj 0 0 0 1 k /GS1 gs 0.074 Tw 0 -1.25 TD (3.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(S)-16(hahedi)]TJ /Span<>> BDC ( )Tj EMC [(K, F)10(uller)]TJ /Span<>> BDC ( )Tj EMC [(G, Bol)35(us)]TJ /Span<>> BDC ( )Tj EMC [(R, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. L)35(ong-ter)-16(m r)-37(isk of)]TJ /Span<>> BDC ( )Tj EMC [(a)-17(cute di)-16(ver)]TJ 0 Tw 25.99 0 Td (-)Tj 0.052 Tw -27.286 -1.25 Td [(t)-32(icul)-30.9(i)-24(t)-32(is among p)32(a)15(t)-32(ients wi)-24(t)-13(h inc)-23.9(ident)15(al di)-16(ver)-22(t)-32(icul)30.1(osis found dur)-37(ing )]TJ 0 Tw T* [(col)30(onoscopy. )]TJ /T1_2 1 Tf 0.301 Tw 5.788 0 Td (Clin Gastroenterol Hepatol.)Tj /T1_0 1 Tf ( 2013;11\(12\):1609\2261613. )Tj 0 Tw -5.788 -1.25 Td [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1016/j.cgh.2013.06.020)Tj 0 0 0 1 k /GS1 gs 0.01 Tc 0.356 Tw -1.847 -1.25 Td [(4)0.5(.)]TJ /Span<>> BDC 0.815 0 Td ( )Tj EMC 0.51 0 Td [(C)0.5(o)0.5(l)0.5(l)-30.5(i)0.5(ns)]TJ /Span<>> BDC 2.77 0 Td ( )Tj EMC [(D)0.5(,)0.5( W)-15.5(i)0.5(n)0.5(t)0.5(e)0.5(r)]TJ /Span<>> BDC 4.667 0 Td ( )Tj EMC [(D)0.5(C.)0.5( M)-23.5(o)0.5(d)0.5(e)0.5(r)-14.5(n)0.5( c)0.5(o)0.5(n)0.5(c)0.5(e)0.5(pt)0.5(s)0.5( i)0.5(n)0.5( d)0.5(i)-15.5(v)0.5(er)-21.5(t)-31.5(i)0.5(c)0.5(u)0.5(l)-15.5(a)0.5(r)0.5( d)0.5(is)]TJ 0 Tc 0 Tw 18.525 0 Td (-)Tj 0.009 Tc -0.009 Tw -27.286 -1.25 Td (ease. )Tj /T1_2 1 Tf 0.354 Tw 2.725 0 Td (J Clin Gastroenterol)Tj /T1_0 1 Tf [(. 2015;49\(5\):358\226369. d)-16.4(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs -0.009 Tw (10.1097/)Tj 0 Tc 0 Tw -2.725 -1.25 Td (MCG.0000000000000297)Tj 0 0 0 1 k /GS1 gs 0.176 Tw T* (5.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(W)12(ar)-15(ner)]TJ /Span<>> BDC ( )Tj EMC [(E, Cr)-37(ight)17(on)]TJ /Span<>> BDC ( )Tj EMC [(EJ, M)-24(oineddin)]TJ /Span<>> BDC ( )Tj EMC [(R, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. F)10(our)-22(teen-year stud)17(y )]TJ 0.253 Tw -1.296 -1.25 Td (of)Tj /Span<>> BDC ( )Tj EMC [(hospi)-23.9(t)15(al admissions for di)-16(ver)-21.9(t)-32(icul)-16(ar disease in Ont)15(ar)-36.9(io. )]TJ /T1_2 1 Tf (Can J )Tj 0 Tw T* (Gastroenterol. )Tj /T1_0 1 Tf 0.023 Tw 5.809 0 Td [(2)20(0)-16(0)30(7 F)10(eb;2)107(1\(2\):9)72(7)48(-)-32(9)62(. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1155/2007/943460)Tj 0 0 0 1 k /GS1 gs 0.281 Tw -5.809 -1.25 Td (6.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(K)-16(ang)]TJ /Span<>> BDC ( )Tj EMC [(JY, Hoar)-24(e)]TJ /Span<>> BDC ( )Tj EMC [(J, T)35(int)17(o)]TJ /Span<>> BDC ( )Tj EMC [(A, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Di)-16(ver)-21.9(t)-32(icul)-16(ar disease of)]TJ /Span<>> BDC ( )Tj EMC [(t)-13(he )]TJ 0.229 Tw -1.296 -1.25 Td [(col)30(on)]TJ /Span<>> BDC ( )Tj EMC [(\227 on t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(r)-37(ise: a)]TJ /Span<>> BDC ( )Tj EMC [(stud)17(y of)]TJ /Span<>> BDC ( )Tj EMC [(hospi)-24(t)15(al admissions in Engl)-16(and )]TJ 0.011 Tc 0.394 Tw T* [(be)-11.6(t)-31.5(ween )0.5(1989/)0.5(1990 )0.5(and )0.5(1999/)0.5(2000. )]TJ /T1_2 1 Tf 16.967 0 Td [(Ali)0.5(ment)0.5( Pha)0.5(r)-13.6(mac)0.5(ol )0.5(Ther)0.5(.)]TJ /T1_0 1 Tf 0 Tc 0 Tw 10.671 0 Td ( )Tj 0.023 Tw -27.638 -1.25 Td [(2003;17\(9\):1189\2261195. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1046/j.1365-2036.2003.01551.x)Tj 0 0 0 1 k /GS1 gs 0.061 Tw T* (7.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (Etzioni)Tj /Span<>> BDC ( )Tj EMC 3.125 0 Td [(D)20(A, Ma)-17(ck)]TJ /Span<>> BDC ( )Tj EMC [(TM, Bear)-21.9(t)]TJ /Span<>> BDC ( )Tj EMC [(RW, )0.5(e)-12(t)]TJ /Span<>> BDC ( )Tj EMC 10.792 0 Td [(al. )0.5(Di)-16(ver)-22(t)-32(icul)-30.9(i)-24(t)-32(is )0.5(in t)-13(he)]TJ /Span<>> BDC ( )Tj EMC 9.703 0 Td [(U)13(ni)-24(ted )]TJ 0.024 Tw -24.916 -1.25 Td [(S)15(t)15(a)15(tes: 1998-2005: changing p)32(a)15(t)-30(ter)-14.9(ns of)]TJ /Span<>> BDC ( )Tj EMC [(disease and tr)-24(ea)15(tment. )]TJ /T1_2 1 Tf 0 Tw (Ann )Tj T* (Surg.)Tj /T1_0 1 Tf 0.023 Tw [( 2009;249\(2\):210\226217. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw [(10.1097/SL)-34.9(A.0b013e3181952888)]TJ 0 0 0 1 k /GS1 gs 0.147 Tw T* (8.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(T)47(heod)-16(or)-32(opoul)30.1(os)]TJ /Span<>> BDC ( )Tj EMC [(D. Cur)-24(r)-24(ent opt)-32(ions for t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(emer)-31.9(gency mana)-17(ge)]TJ 0 Tw (-)Tj -0.039 Tw -1.296 -1.25 Td (ment of)Tj /Span<>> BDC ( )Tj EMC [(di)-16(ver)-22(t)-32(icul)-15.9(ar disease and opt)-31.9(ions t)17(o)]TJ /Span<>> BDC ( )Tj EMC [(r)-24(educe t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(need for col)30.1(os)]TJ 0 Tw (-)Tj T* [(t)17(omy. )]TJ /T1_2 1 Tf 0.127 Tw 2.657 0 Td [(Clin Colon R)21(ectal Surg.)]TJ /T1_0 1 Tf [( 2018;31\(4\):229\226235. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1055/s-)Tj -2.657 -1.25 Td (0037-1607965)Tj 0 0 0 1 k /GS1 gs -0.01 Tc 0.196 Tw T* (9.)Tj /Span<>> BDC ( )Tj EMC 1.266 0 Td (Hupfeld)Tj /Span<>> BDC ( )Tj EMC [(L, Bur)-32(char)-22(t)-13(h)]TJ /Span<>> BDC ( )Tj EMC [(J, P)10(ommer)-32(gaar)-24(d)]TJ /Span<>> BDC ( )Tj EMC [(HC, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. R)-24(isk f)16(a)-17(c)-16(t)17.1(or)-10(s for)-10( )]TJ -0.011 Tw -1.266 -1.25 Td [(r)-24(ecur)-24(r)-24(ence af)-28(ter a)-17(cute col)30.1(onic di)-16(ver)-22(t)-31.9(icul)-31(i)-24(t)-31.9(is: a)]TJ /Span<>> BDC ( )Tj EMC [(sy)-12.9(stema)15(t)-32(ic r)-24(ev)-16(iew. )]TJ /T1_2 1 Tf [(Int J)-10( )]TJ 0.011 Tw T* (Colorectal Dis.)Tj /T1_0 1 Tf [( 2017;32\(5\):611\226622. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0.01 Tw (10.1007/s00384-017-2762-3)Tj 0 0 0 1 k /GS1 gs 0 Tc 0.298 Tw T* (10.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Ho)Tj /Span<>> BDC ( )Tj EMC (VP, Nash)Tj /Span<>> BDC ( )Tj EMC (GM, Milsom)Tj /Span<>> BDC ( )Tj EMC [(JW, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Ident)-32(if)-28(ica)15.1(t)-32(ion of)]TJ /Span<>> BDC ( )Tj EMC [(di)-16(ver)]TJ 0 Tw 25.49 0 Td (-)Tj 0.215 Tw 1.769 37.5 Td [(t)-32(icul)-30.9(i)-24(t)-32(is p)32(a)15(t)-32(ients a)15(t high r)-37(isk for r)-24(ecur)-23.9(r)-24(ence and po)-16(or outcomes. )]TJ /T1_2 1 Tf 0.005 Tc 0.35 Tw T* [(J T)55.8(rauma Acute Care Surg.)]TJ /T1_0 1 Tf [( 2015;78\(1\):112\226119. d)-16.3(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs -0.005 Tw (10.1097/)Tj 0 Tc 0 Tw T* [(T)35(A.0000000000000489)]TJ 0 0 0 1 k /GS1 gs -0.004 Tw T* (11.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Hajibandeh)Tj /Span<>> BDC ( )Tj EMC (S, Hajibandeh)Tj /Span<>> BDC ( )Tj EMC [(S, Smar)-21.9(t)]TJ /Span<>> BDC ( )Tj EMC [(NJ, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Me)-12(t)15(a-anal)35.1(y)-13(sis of)]TJ /Span<>> BDC ( )Tj EMC [(t)-13(he )]TJ 0.058 Tw -1.796 -1.25 Td [(demo)-16(gr)-33(aphic and p)25(r)-32(o)-16(gnost)-32(ic signif)-28(icance of)]TJ /Span<>> BDC ( )Tj EMC [(r)-37(ight-sided ver)-10(sus lef)-27.9(t-)]TJ 0.189 Tw T* [(sided a)-17(cute di)-16(ver)-22(t)-32(icul)-30.9(i)-24(t)-32(is. )]TJ /T1_2 1 Tf (Colorectal Dis.)Tj /T1_0 1 Tf ( 2020;22\(12\):1908\2261923. )Tj 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1111/codi.15226)Tj 0 0 0 1 k /GS1 gs -0.02 Tw -1.847 -1.25 Td (12.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Guy)22(a)15(t)-30(t)]TJ /Span<>> BDC ( )Tj EMC (GH, Oxman)Tj /Span<>> BDC ( )Tj EMC [(AD, V)-15(ist)]TJ /Span<>> BDC ( )Tj EMC [(GE, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC (al. GRADE: an)Tj /Span<>> BDC ( )Tj EMC [(emer)-32(ging consen)]TJ 0 Tw (-)Tj 0.034 Tw -1.796 -1.25 Td [(sus )0.6(on )0.5(r)-33(a)15(t)-32(ing )0.6(qual)-31(i)-24(t)-9.9(y )0.5(of)]TJ /Span<>> BDC ( )Tj EMC 9.802 0 Td [(ev)-16(idence )0.6(and )0.5(str)-23.9(eng)17(t)-13(h )0.5(of)]TJ /Span<>> BDC ( )Tj EMC 10.392 0 Td [(r)-24(ecommend)42.1(a)14.9(t)-31.9(ions)]TJ /T1_2 1 Tf 0 Tw (. )Tj -20.194 -1.25 Td (BMJ.)Tj /T1_0 1 Tf -0.003 Tw [( 2008;336\(7650\):924\226926. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1136/bmj.39489.470347.AD)Tj 0 0 0 1 k /GS1 gs 0.037 Tw T* (13.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Br)-32(ozek)]TJ /Span<>> BDC ( )Tj EMC 2.995 0 Td [(JL, )0.6(Akl)]TJ /Span<>> BDC ( )Tj EMC 2.879 0 Td [(EA, )0.6(Jaeschk)10(e)]TJ /Span<>> BDC ( )Tj EMC 5.391 0 Td [(R, )0.5(e)-12(t)]TJ /Span<>> BDC ( )Tj EMC 2.082 0 Td [(al. )0.6(G)19.9(r)-32.9(ading )0.5(qual)-30.9(i)-24(t)-10(y )0.5(of)]TJ /Span<>> BDC ( )Tj EMC 8.899 0 Td [(ev)-16(idence )]TJ 0.22 Tw -24.042 -1.25 Td [(and str)-23.9(eng)17(t)-13(h of)]TJ /Span<>> BDC ( )Tj EMC [(r)-24(ecommend)42(a)15(t)-32(ions in cl)-31(inical p)25(r)-33(a)-17(c)-16(t)-32(ice guidel)-30.9(ines: )]TJ -0.019 Tw T* [(p)32(ar)-22(t 2 of)]TJ /Span<>> BDC ( )Tj EMC [(3. T)46.9(he)]TJ /Span<>> BDC ( )Tj EMC [(GRADE app)25(r)-32(oa)-17(ch t)17(o)]TJ /Span<>> BDC ( )Tj EMC [(gr)-33(ading qual)-30.9(i)-24(t)-10(y of)]TJ /Span<>> BDC ( )Tj EMC [(ev)-16(idence about )]TJ 0.001 Tc 0.349 Tw T* [(dia)-16.6(gnost)-31.6(ic tests and str)-32.6(a)15.4(tegies. )]TJ /T1_2 1 Tf -0.001 Tw (Allergy.)Tj /T1_0 1 Tf 0.349 Tw [( 2009;64\(8\):)0.5(1109\2261116.)1( )]TJ 0 Tc 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1111/j.1398-9995.2009.02083.x)Tj 0 0 0 1 k /GS1 gs 0.21 Tw -1.847 -1.25 Td (14.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Hinche)-11(y)]TJ /Span<>> BDC ( )Tj EMC [(EJ, S)-24(chaal)]TJ /Span<>> BDC ( )Tj EMC [(PH, R)-24(ichar)-24(ds)]TJ /Span<>> BDC ( )Tj EMC [(GK. T)50(r)-24(ea)15(tment of)]TJ /Span<>> BDC ( )Tj EMC [(per)-24(for)-33(a)15(ted )]TJ 0.078 Tw -1.796 -1.25 Td [(di)-16(ver)-21.9(t)-32(icul)-16(ar disease of)]TJ /Span<>> BDC ( )Tj EMC [(t)-13(he col)30.1(on. )]TJ /T1_2 1 Tf (Adv Surg.)Tj /T1_0 1 Tf ( 1978;12:85\226109. PMID: )Tj 0 Tw T* (735943.)Tj 0.259 Tw T* (15.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(M)-24(or)-33(a )0.5(L)35(opez)]TJ /Span<>> BDC ( )Tj EMC 5.282 0 Td [(L, )0.5(Ser)-24(r)-33(a )0.5(Pl)-15.9(a)]TJ /Span<>> BDC ( )Tj EMC [(S, )0.5(Ser)-23.9(r)-33(a-Ar)-33(a)-17(c)-23.9(il)]TJ /Span<>> BDC ( )Tj EMC [(X, )0.5(e)-11.9(t)]TJ /Span<>> BDC ( )Tj EMC [(al. )0.5(Appl)-30.9(ica)15(t)-32(ion )]TJ 0.228 Tw -7.078 -1.25 Td (of)Tj /Span<>> BDC ( )Tj EMC (a)Tj /Span<>> BDC ( )Tj EMC [(modif)-28(ied Nef)-56(f cl)-16(assif)-27.9(ica)15(t)-32(ion t)17(o)]TJ /Span<>> BDC ( )Tj EMC [(p)31.9(a)15.1(t)-32(ients wi)-24(t)-13(h uncom)10(pl)-31(ica)15.1(ted )]TJ 0 Tw T* [(di)-16(ver)-21.9(t)-32(icul)-31(i)-24(t)-31.9(is. )]TJ /T1_2 1 Tf 0.001 Tw 5.836 0 Td (Colorectal Dis.)Tj /T1_0 1 Tf [( 2013;15\(12\):1442\2261447. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1111/)Tj -5.836 -1.25 Td (codi.12375)Tj 0 0 0 1 k /GS1 gs 0.06 Tw T* (16.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Sall)-31(inen)]TJ /Span<>> BDC ( )Tj EMC [(V)17(J, L)35(epp\344niemi)]TJ /Span<>> BDC ( )Tj EMC [(AK, Mentul)-15.9(a)]TJ /Span<>> BDC ( )Tj EMC [(P)35(J. S)15.1(t)15(a)-17(ging of)]TJ /Span<>> BDC ( )Tj EMC [(a)-17(cute di)-16(ver)]TJ 0 Tw 25.49 0 Td (-)Tj 0.003 Tc 0.35 Tw -27.286 -1.25 Td [(t)-32.2(icul)-31.1(i)-24.2(t)-32.2(is based on cl)-31.2(inical, r)-33.2(adiol)29.8(o)-16.2(gic, and phy)-13.2(siol)29.8(o)-16.2(gic p)31.8(ar)-33.2(ame)]TJ 0 Tc 0 Tw (-)Tj T* [(ter)-10(s. )]TJ /T1_2 1 Tf 0.086 Tw 2.148 0 Td [(J T)56(rauma Acute Care Surg.)]TJ /T1_0 1 Tf [( 2015;78\(3\):543\226551. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1097/)Tj -2.148 -1.25 Td [(T)35(A.0000000000000549)]TJ 0 0 0 1 k /GS1 gs -0.141 Tw T* (17.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (\221\036\035\t\020\017\027)Tj /Span<>> BDC ( )Tj EMC (\222.\202., \236\r\026\001\022\017\027)Tj /Span<>> BDC ( )Tj EMC (\200.\230., \202\004\022\026\f\024\r)Tj /Span<>> BDC ( )Tj EMC (\224.\236., \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. \025\035\017\027\017\004\036\f\022\017\036 )Tj 0.184 Tw -1.796 -1.25 Td 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\235\017\017\024\035\024\020\017\004\036\f\022\017 \f\021\026\002\017\ \035\034\027\t\b \023\026\006\017\036\027\021\024\r \035\026\023\026\030\ \024)Tj 0 Tw (-)Tj 0.539 Tw T* [(\f\022\024\023\017\004\036\f\022\026\016 )0.6(\f\017\020\n\024\017\007\220\022\021\024\n\017\016 )0.6(\n\024\032\036\021 )0.5(\r\t\023\024\035\027\016\021\034\f\016 )]TJ 0.109 Tw T* (\023\030\017)Tj /Span<>> BDC ( )Tj EMC (\210\210\212 \023\024)Tj /Span<>> BDC ( )Tj EMC (Hinch\036y 3\2264)Tj /Span<>> BDC ( )Tj EMC (\f\021\026\007\017\017 \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\017 \027\026\035\017\004\017\017 \021\036\b)Tj 0 Tw (-)Tj -0.028 Tw T* [(\027\017\004\036\f\022\017\b \027\026\r\t\022\024\r )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC (\f\024\024\021\r\036\021\f\021\r\031\033\013\036\020\024 \024\002\024\030\ \031\007\024\r\026\027\017\016 )Tj 0.115 Tw T* ([58]. \200)Tj /Span<>> BDC ( )Tj EMC 3.277 0 Td [(\f\017\f\021\036\n\026\021\017\004\036\f\022\024\n )0.5(\024\002\024\030\036 )0.5([79] \023\030\017\r\036\007\036\027 )0.5(\026\027\026)]TJ 0 Tw (-)Tj 0.021 Tw -3.277 -1.218 Td (\035\017 \030\036\031\035\034\021\026\021\024\r \035\026\023\026\030\024\ \f\022\024\023\017\004\036\f\022\024\005 \f\017\020\n\024\017\007\220\022\ \021\024\n\017\017 )Tj 0.027 Tw T* (\031)Tj /Span<>> BDC ( )Tj EMC (104 \023\026\006\017\036\027\021\024\r, \210\206 \002\t\035\026 \r\t\023\ \024\035\027\036\027\026 \031)Tj /Span<>> BDC ( )Tj EMC (84, \023\036\030\r\017\004\027\026\016 )Tj 0.066 Tw T* [(\030\036\036\022\006\017\016 )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC 4.856 0 Td (\026\027\026\f\021\024\n\024\024\n)Tj /Span<>> BDC ( )Tj EMC 5.621 0 Td [(\227 )0.5(\031)]TJ /Span<>> BDC ( )Tj EMC 2.042 0 Td [(20 )0.5(\023\026\006\017\036\027\021\024\r. )0.6(\224\030\036\007\027\036\036 )]TJ 0.049 Tw -12.519 -1.218 Td (\r\030\036\n\016 \024\023\036\030\026\006\017\017 \r\026\030\034\017\030\ \024\r\026\035\024\f\034 \024\021 115 \007\024)Tj /Span<>> BDC ( )Tj EMC (200 \n\017\027\031\021, )Tj 0.116 Tw T* [(\004\026\f\021\024\021\026 )0.5(\022\024\027\r\036\030\f\017\017 )0.5(\027\026)]TJ /Span<>> BDC ( )Tj EMC (\035\026\023\026\030\024\021\024\n\017\033)Tj /Span<>> BDC ( )Tj EMC 15.397 0 Td [(\227 \024\021 )0.5(0 \007\024)]TJ /Span<>> BDC ( )Tj EMC 4.769 0 Td (19%, )Tj 0.002 Tw -20.166 -1.218 Td (\f\030\036\007\027\016\016 \023\030\024\007\024\035\032\017\021\036\035\034\ \027\024\f\021\034 \023\030\036\002\t\r\026\027\017\016 \r)Tj /Span<>> BDC ( )Tj EMC (\f\021\026\006\017\024\027\026)Tj 0 Tw (-)Tj 0.002 Tw T* (\030\036 \f\024\f\021\026\r\035\016\035\026 \024\021 6 \007\024)Tj /Span<>> BDC ( )Tj EMC (16 \007\027\036\005. \215\024\r\021\024\030\027\024\036 \b\017\030\031\030\ \020\017\004\036)Tj 0 Tw (-)Tj 0.089 Tw T* (\f\022\024\036 \r\n\036\001\026\021\036\035\034\f\021\r\024 \023\024\021\ \030\036\002\024\r\026\035\024\f\034 \031)Tj /Span<>> BDC ( )Tj EMC (2)Tj /Span<>> BDC ( )Tj EMC (\(1,9%\) \023\026\006\017)Tj 0 Tw (-)Tj T* (\036\027\021\024\r. \214\036\021\026\035\034\027\024\f\021\034 \f\024\f\021\ \026\r\017\035\026 2,9%.)Tj 0.635 Tw T* (\216\017\030\031\030\020\017\004\036\f\022\026\016 \f\021\030\026\021\036\ \020\017\016 \022\024\027\021\030\024\035\016 \023\024\r\030\036\032\007\ \036\027\017\005 )Tj -0.037 Tw T* [(\(Dama)-17(ge Contr)-31.9(ol Sur)-32(ger)-24(y\) \n\024\032\036\021 \002\t\021\034 \023\030\017\n\036\027\036\027\026\ \031)]TJ /Span<>> BDC ( )Tj EMC (\023\026)Tj 0 Tw (-)Tj 0.162 Tw T* (\006\017\036\027\021\024\r \r)Tj /Span<>> BDC ( )Tj EMC (\220\022\f\021\030\036\n\026\035\034\027\024\n \235\017\017\024\035\024\ \020\017\004\036\f\022\024\n \f\024\f\021\024\016)Tj 0 Tw (-)Tj 0.107 Tw T* (\027\017\017 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\030\026\r\017\021\017\017 \026\002\007\024\n\017\027\026\035\034\027\024\ \020\024 \f\036\023\f\017\f\026 \027\026)Tj /Span<>> BDC ( )Tj EMC (\235\024\027\036 )Tj 0.064 Tw T* (\023\036\030\017\021\024\027\017\021\026, \024\002\031\f\035\024\r\035\036\ \027\027\024\020\024 \024\f\035\024\032\027\036\027\017\016\n\017 \212\207\ [80]. )Tj -0.029 Tw T* [(\215\036\030\r\024\027\026\004\026\035\034\027\026\016 )0.5(\024\023\036\030\026\006\017\016 \023\030\036\007\023\030\017\027\017\n\026\ \036\021\f\016 \007\035\016 \035\017\022)]TJ 0 Tw (-)Tj 0.019 Tw T* [(\r\017\007\026\006\017\017 )0.5(\023\030\017\004\017\027\t )0.6(\f\036\023\f\017\f\026, )0.5(\026)]TJ /Span<>> BDC ( )Tj EMC 12.044 0 Td [(\023\024\f\035\036\007\031\033\013\026\016 )0.6(\027\026\023\030\026\r\035\036)]TJ 0 Tw (-)Tj 0.006 Tw -12.044 -1.218 Td (\027\026 \027\026)Tj /Span<>> BDC ( )Tj EMC [(\026\027\026\021\024\n\017\004\036\f\022\024\036 \r\024\f\f\021\026\027\024\ \r\035\036\027\017\036 )0.5(\027\036\023\030\036\030\t\r\027\024\f\021\017 )]TJ 0 Tw T* (\032\036\035\031\007\024\004\027\024-\022\017\001\036\004\027\024\020\024\ \021\030\026\022\021\026 [81].)Tj 0.405 Tw T* (\206\036\n\024\007\017\027\026\n\017\004\036\f\022\017 \027\036\f\021\026\ \002\017\035\034\027\t\036 \023\026\006\017\036\027\021\t \027\036 \n\024\ )Tj 0 Tw (-)Tj 0.107 Tw T* (\020\031\021 \002\t\021\034 \024\023\021\017\n\026\035\034\027\t\n\017 \022\ \026\027\007\017\007\026\021\026\n\017 \007\035\016 \023\024\r\021\024\030\ \027\t\b )Tj 0.724 Tw T* [(\r\024\f\f\021\026\027\024\r\017\021\036\035\034\027\t\b )0.6(\024\023\036\030\026\006\017\005. )0.6(\215\024\f\035\036 )0.5(\023\036\030\r\017\004\027\024\005 )]TJ 0.186 Tw T* (\024\023\036\030\026\006\017\017, \022\024\021\024\030\026\016 \007\024\035\ \032\027\026 \002\t\021\034 \024\020\030\026\027\017\004\036\027\026 \021\ \024\035\034\022\024 )Tj 0.05 Tw 23.244 64.543 Td (\031\f\021\030\026\027\036\027\017\036\n \017\f\021\024\004\027\017\022\026\ \f\036\023\f\017\f\026, \023\026\006\017\036\027\021 \023\036\030\036\r\ \024\007\017\021)Tj 0 Tw (-)Tj 0.079 Tw T* (\f\016 \r)Tj /Span<>> BDC ( )Tj EMC (\024\021\007\036\035\036\027\017\036 \017\027\021\036\027\f\017\r\027\024\ \005 \021\036\030\026\023\017\017 \007\035\016 \022\024\030\030\036\022\006\ \017\017 )Tj 0.207 Tw T* (\235\017\017\024\035\024\020\017\004\036\f\022\017\b \027\026\030\031\001\ \036\027\017\005 \017)Tj /Span<>> BDC ( )Tj EMC (\007\024\f\021\017\032\036\027\017\016 \235\017\017\024)Tj 0 Tw (-)Tj T* (\035\024\020\017\004\036\f\022\024\005 \f\021\026\002\017\035\034\027\024\ \f\021\017 [82].)Tj 0.2 Tw T* [(\200 \017\f\f\035\036\007\024\r\026\027\017\017 K)-16(afk)-17(a-R)-23.9(i)-24(tsch R. [100] 51 \002\024\035\034\027\024\n\031 )]TJ 0.003 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\210\210\212 \023\024)Tj /Span<>> BDC ( )Tj EMC (Hinch\036y 3 \()Tj /T1_2 1 Tf 0 Tw (n)Tj /T1_1 1 Tf 0.003 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (40\) \017)Tj /Span<>> BDC ( )Tj EMC (4 \()Tj /T1_2 1 Tf 0 Tw (n)Tj /T1_1 1 Tf 0.003 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (11\) \023\036\030\r\024\027\026\004\026\035\034)Tj 0 Tw (-)Tj -0.006 Tw 0 -1.218 TD [(\027\024 \023\030\024\r\024\007\017\035\026\f\034 \024\020\030\026\027\017\ \004\036\027\027\026\016 )0.5(\030\036\036\022\006\017\016, \023\030\024\n\t\r\026\027\017\036 )]TJ 0.153 Tw 0 -1.218 TD (\017)Tj /Span<>> BDC ( )Tj EMC [(\r\030\036\n\036\027\027\024\036 )0.5(\026\022\030\t\021\017\036 )0.5(\002\030\033\001\027\024\005 \023\024\035\024\f\021\017, )0.5(\026\021\036\n \004\036)]TJ 0 Tw (-)Tj 0.13 Tw T* [(\030\036 )0.5(24\22648)]TJ /Span<>> BDC ( )Tj EMC 4.677 0 Td [(\004. )0.5(\023\030\024\r\024\007\017\035\026\f\034 )0.6(\r\021\024\030\026\016 )0.5(\030\036\022\024\027\f\021\030\031\022\021\017\r\027\026\016 )]TJ 0.278 Tw -4.677 -1.218 Td (\024\023\036\030\026\006\017\016, \027\036\023\030\036\030\t\r\027\024\f\ \021\034 \022\017\001\036\004\027\017\022\026 \002\t\035\026 \r\024\f\f\021\ \026)Tj 0 Tw (-)Tj 0.08 Tw T* (\027\024\r\035\036\027\026 \031)Tj /Span<>> BDC ( )Tj EMC 4.471 0 Td (38)Tj /Span<>> BDC ( )Tj EMC (\(84%\) \023\026\006\017\036\027\021\024\r, \017)Tj /Span<>> BDC ( )Tj EMC 10.201 0 Td [(\027\017\b )0.5(\031)]TJ /Span<>> BDC ( )Tj EMC (4)Tj /Span<>> BDC ( )Tj EMC (\227 \f)Tj /Span<>> BDC ( )Tj EMC (\235\024\030)Tj 0 Tw (-)Tj 0.218 Tw -14.672 -1.218 Td (\n\017\030\024\r\026\027\017\036\n \023\036\021\035\036\r\024\005 \017\035\ \036\024\f\021\024\n\t. \211)Tj /Span<>> BDC ( )Tj EMC (5)Tj /Span<>> BDC ( )Tj EMC (\(13%\) \002\024\035\034)Tj 0 Tw (-)Tj 0.048 Tw 0 -1.218 TD (\027\t\b \030\026\r\017\035\026\f\034 \027\036\f\024\f\021\024\016\021\036\ \035\034\027\024\f\021\034 \026\027\026\f\021\024\n\024\026, \031)Tj /Span<>> BDC ( )Tj EMC (\007\r\031\b )Tj 0.344 Tw 0 -1.218 TD (\017)Tj /Span<>> BDC ( )Tj EMC (\027\017\b \023\024\021\030\036\002\024\r\026\035\024\f\034 \027\026\035\ \024\032\036\027\017\036 \023\036\021\035\036\r\024\005 \017\035\036\024\ )Tj 0 Tw (-)Tj -0.038 Tw 0 -1.218 TD (\f\021\024\n\t, \026)Tj /Span<>> BDC ( )Tj EMC (\031 3)Tj /Span<>> BDC ( )Tj EMC (\227 \r\t\023\024\035\027\036\027\017\036 \210\206. \210\002\013\026\016\ \035\036\021\026\035\034\027\024\f\021\034 \f\024)Tj 0 Tw (-)Tj 0.041 Tw T* [(\f\021\026\r\017\035\026 )0.5(9,8%, \031)]TJ /Span<>> BDC ( )Tj EMC 6.605 0 Td (35)Tj /Span<>> BDC ( )Tj EMC 1.274 0 Td [(\(76%\) )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC [(46 )0.5(\r\t\032\017\r\001\017\b )0.5(\023\026\006\017\036\027\021\024\r )]TJ 0.211 Tw -7.878 -1.218 Td (\r\024\f\f\021\026\027\024\r\035\036\027\026 \027\036\023\030\036\030\t\r\ \027\024\f\021\034 \032\036\035\031\007\024\004\027\024-\022\017\001\036\ \004\027\024)Tj 0 Tw (-)Tj 0.05 Tw T* (\020\024 \021\030\026\022\021\026 \f)Tj /Span<>> BDC ( )Tj EMC (\035\017\022\r\017\007\026\006\017\036\005 \035\026\023\026\030\024\f\021\ \024\n\t \022)Tj /Span<>> BDC ( )Tj EMC (\n\024\n\036\027\021\031 \r\t)Tj 0 Tw (-)Tj T* (\023\017\f\022\017 \017)Tj /Span<>> BDC ( )Tj EMC (\f\021\026\006\017\024\027\026\030\026.)Tj 0.182 Tw T* (\200 \024\007\027\024\n \017\f\f\035\036\007\024\r\026\027\017\017, \020\ \007\036 \f\030\026\r\027\017\r\026\035\017 \021\030\026\007\017\006\017\ \024\027)Tj 0 Tw (-)Tj 0.024 Tw T* (\027\031\033 \f\021\030\026\021\036\020\017\033 \f)Tj /Span<>> BDC ( )Tj EMC [(\021\026\022\021\017\022\024\005 Dama)-17(ge Contr)-31.9(ol Sur)-31.9(ger)-24(y, \027\036 )]TJ -0.039 Tw T* (\002\t\035\024 \r\t\016\r\035\036\027\024 \027\017\022\026\022\017\b \027\ \026\004\017\n\t\b \030\026\035\017\004\017\005 \r)Tj /Span<>> BDC ( )Tj EMC (\004\026\f\021\024\021\036 )Tj 0 Tw T* (\024\f\035\024\032\027\036\027\017\005 \017)Tj /Span<>> BDC ( )Tj EMC (\035\036\021\026\035\034\027\024\f\021\017 [83].)Tj 0.195 Tw T* (\200 \224\221\202 \021\024\035\034\022\024 \f)Tj /Span<>> BDC ( )Tj EMC (2002 \023\024)Tj /Span<>> BDC ( )Tj EMC (2007 \020\020. \004\026\f\021\024\021\026 \220\022\f\021\030\036\027)Tj 0 Tw (-)Tj 0.082 Tw T* (\027\t\b \020\024\f\023\017\021\026\035\017\026\006\017\005 \031\r\036\035\ \017\004\017\035\026\f\034 \027\026)Tj /Span<>> BDC ( )Tj EMC (9,5%, \027\024 \021\024\035\034\022\024 )Tj -0.005 Tw T* (\031)Tj /Span<>> BDC ( )Tj EMC (12,2% \023\026\006\017\036\027\021\024\r \002\t\035\017 \r\t\023\024\035\ \027\036\027\t \030\036\036\022\006\017\016 \022\017\001\022\017. )Tj -0.052 Tw T* (\232\026\f\021\024\021\026 \r\t\023\024\035\027\036\027\017\016 \023\035\ \026\027\024\r\t\b \024\023\036\030\026\006\017\005 \031\r\036\035\017\004\ \017\035\026\f\034 )Tj -0.013 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC (38,7% [84], \026)Tj /Span<>> BDC ( )Tj EMC (\027\036\024\021\035\024\032\027\t\b \r\n\036\001\026\021\036\035\034\f\021\ \r \f\027\017\017\035\026\f\034 )Tj 0 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (28% \007\024)Tj /Span<>> BDC ( )Tj EMC (16% [84,85,86].)Tj 0.182 Tw T* (\200 \027\026\f\021\024\016\013\036\036 \r\030\036\n\016 \027\036 \f\031\ \013\036\f\021\r\031\036\021 \020\035\024\002\026\035\034\027\t\b \024\006\ \036)Tj 0 Tw (-)Tj 0.128 Tw T* [(\027\024\022, )0.5(\022\024\021\024\030\t\036 )0.5(\017\n\036\035\017 )0.5(\002\t )0.5(\017\027\007\017\r\017\007\031\026\035\034\027\031\033 )0.6(\023\030\024\020\027\024\f\021\017)]TJ 0 Tw (-)Tj 0.131 Tw T* [(\004\036\f\022\031\033 )0.5(\006\036\027\027\024\f\021\034 )0.6(\007\035\016 )0.5(\017\f\b\024\007\026 )0.5(\024\f\021\030\024\020\024 )0.6(\007\017\r\036\030\021\017\022\031\035\017\021\026 )]TJ 0.057 Tw T* ([87]. \200\026\032\027\024 \024\021\n\036\021\017\021\034, \004\021\024 \ \007\017\r\036\030\021\017\022\031\035 \016\r\035\016\036\021\f\016 \035\ \017\001\034 )Tj 0.574 Tw T* (\220\023\017\235\036\027\024\n\036\027\024\n \n\027\024\032\036\f\021\r\026\ \n\024\030\235\024\235\031\027\022\006\017\024\027\026\035\034\027\t\b \ )Tj 0.038 Tw T* (\017\n\036\027\036\027\017\005 \f\021\036\027\022\017 \024\002\024\007\024\ \004\027\024\005 \022\017\001\022\017. \236\f\022\031\f\f\021\r\036\027\027\ \t\005 )Tj 0.347 Tw T* [(\017\027\021\036\035\035\036\022\021, \r\024\n\024\032\027\024, )0.5(\023\024\n\024\032\036\021 \017\f\f\035\036\007\024\r\026\027\017\016\n \ \024\021)]TJ 0 Tw (-)Tj 0.017 Tw T* (\007\036\035\034\027\t\b \023\030\024\020\027\024\f\021\017\004\036\f\022\ \017\b \235\026\022\021\024\030\024\r \023\031\021\036\n \024\002\030\026\ \002\024\021\022\017 )Tj 0.215 Tw T* (\021\t\f\016\004 \022\035\017\027\017\004\036\f\022\017\b, \220\022\024\035\ \024\020\017\004\036\f\022\017\b, \n\036\021\026\002\024\035\017\004\036\ \f\022\017\b )Tj 0 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\030\026\f\021\031\013\017\b \020\036\027\024\n\027\t\b \007\026\027\027\ \t\b [88].)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 275.0305 225.5318 Tm [(\020)21(\026\027\r\241\224\034\022\031\034)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0 Tc 0.318 Tw 10 0 0 10 274.9606 201.1758 Tm (\210\f\021\030\t\005 \007\017\r\036\030\021\017\022\031\035\017\021 \024\ \002\024\007\024\004\027\024\005 \022\017\001\022\017 \024\021\027\024\f\ \017\021\f\016 )Tj 0.146 Tw T* (\022)Tj /Span<>> BDC ( )Tj EMC (\004\017\f\035\031 \004\026\f\021\t\b \026\002\024\035\036\r\026\027\017\ \005 \r)Tj /Span<>> BDC ( )Tj EMC (\027\036\024\021\035\024\032\027\024\005 \026\002\007\024\n\017)Tj 0 Tw (-)Tj 0.447 Tw T* (\027\026\035\034\027\024\005 \b\017\030\031\030\020\017\017. \210\022\026\ \026\027\017\036\n \027\036\024\021\035\024\032\027\024\005 \n\036\007\017\ )Tj 0 Tw (-)Tj 0.045 Tw 0 -1.218 TD (\006\017\027\f\022\024\005 \023\024\n\024\013\017 \r)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\034\001\017\027\f\021\r\036 \f\035\031\004\026\036\r \026\027\ \017\n\026\033\021\f\016 )Tj 0.22 Tw 0 -1.218 TD (\024\002\013\017\036 \b\017\030\031\030\020\017, \n\036\027\034\001\026\016\ \004\026\f\021\034 \220\021\017\b \023\026\006\017\036\027\021\024\r \007\ \024)Tj 0 Tw (-)Tj 0.203 Tw 0 -1.218 TD (\f\021\026\r\035\016\036\021\f\016 \r)Tj /Span<>> BDC ( )Tj EMC (\f\023\036\006\017\026\035\017\017\030\024\r\026\027\027\t\036 \022\024\ \035\024\023\030\024\022\021\024\035\024\020\017)Tj 0 Tw (-)Tj 0.146 Tw 0 -1.218 TD (\004\036\f\022\017\036 \006\036\027\021\030\t \017\035\017 \024\021\007\036\ \035\036\027\017\016. \212\026\027\027\024\036 \026\002\024\035\036\r\026\ \027\017\036 )Tj 0.565 Tw 0 -1.218 TD (\021\030\036\002\031\036\021 \023\030\024\r\036\007\036\027\017\016 \f\030\ \024\004\027\024\005 \007\017\235\235\036\030\036\027\006\017\026\035\034\ \027\024\005 )Tj 0.472 Tw 0 -1.218 TD [(\007\017\026\020\027\024\f\021\017\022\017 )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC [(\007\030\031\020\017\n\017 )0.5(\024\f\021\030\t\n\017 \b\017\030\031\030\020\017\004\036\f\022\017\n\017\ )]TJ 0.149 Tw 0 -1.218 TD (\026\002\024\035\036\r\026\027\017\016\n\017 \024\030\020\026\027\024\r\ \002\030\033\001\027\024\005 \023\024\035\024\f\021\017 \023\024)Tj /Span<>> BDC ( )Tj EMC (\024\023\030\036)Tj 0 Tw (-)Tj 0.248 Tw 0 -1.218 TD (\007\036\035\036\027\027\024\n\031 \026\035\020\024\030\017\021\n\031 \(\ \235\017\017\022\026\035\034\027\t\036, \035\026\002\024\030\026\021\024\ \030\027\t\036 )Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 0 Tw 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\206)10(\002\036\033 \035\030\032\003\033)30(\n)42(\032)-21(\230\033\241)]TJ 57.136 0 Td (REVIEW)Tj /T1_4 1 Tf 25 0 0 25 506.2772 56.0378 Tm (205)Tj ET endstream endobj 550 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.084 Tw 10 0 0 10 70.8661 724.8299 Tm (\023\024\023\t\021\022\031 \027\036\024\023\036\030\026\021\017\r\027\024\ \020\024 \035\036\004\036\027\017\016 \(\203\210\214\) \f)Tj /Span<>> BDC ( )Tj EMC (\017\f\023\024\035\034\024)Tj 0 Tw (-)Tj 0 -1.218 TD (\r\026\027\017\036\n \021\024\035\034\022\024 \026\027\021\017\002\017\024\ \021\017\022\024\r [58].)Tj 0.046 Tw T* (\215\030\017 \002\024\035\034\001\024\n \007\017\026\n\036\021\030\036 \212\ \202 \026\027\021\017\002\017\024\021\017\022\017 \n\024\020\031\021 \027\ \036 \007\024)Tj 0 Tw (-)Tj 0.206 Tw T* (\f\021\017\004\034 \027\036\024\002\b\024\007\017\n\024\005 \022\024\027\ \006\036\027\021\030\026\006\017\017 \r\027\031\021\030\017 \026\002\f\006\ \036\f\f\026, )Tj 0.354 Tw T* (\004\021\024 \031\r\036\035\017\004\017\r\026\036\021 \004\017\f\035\024\ \027\036\031\007\024\r\035\036\021\r\024\030\017\021\036\035\034\027\t\b\ \030\036)Tj 0 Tw (-)Tj 0.231 Tw T* (\031\035\034\021\026\021\024\r. \217\026\n\036\030 \212\202 4\2265)Tj /Span<>> BDC ( )Tj EMC (\f\n, \023\024-\r\017\007\017\n\024\n\031, \n\024\032\036\021 )Tj -0.015 Tw 0 -1.218 TD (\002\t\021\034 \030\026\031\n\027\t\n \023\030\036\007\036\035\024\n \n\ \036\032\007\031 \023\030\017\n\036\027\036\027\017\036\n \021\024\035\034\ \022\024 )Tj 0.199 Tw 0 -1.218 TD (\026\027\021\017\002\017\024\021\017\022\024\021\036\030\026\023\017\017\ \017)Tj /Span<>> BDC ( )Tj EMC (\004\030\036\f\022\024\032\027\t\n \007\030\036\027\017\030\024\r\026\027\ \017\036\n )Tj 0 Tw T* (\(\232\025\212\) \r)Tj /Span<>> BDC ( )Tj EMC (\f\024\004\036\021\026\027\017\017 \f)Tj /Span<>> BDC ( )Tj EMC (\026\027\021\017\002\017\024\021\017\022\024\021\036\030\026\023\017\036\ \005 [59,60].)Tj 0.303 Tw T* (\200\n\036\f\021\036 \f)Tj /Span<>> BDC ( )Tj EMC (\021\036\n, \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\020\030\036\f\f\017\030\024\r\026\027\017\017 \022\035\017\027\ \017\004\036\f\022\017\b )Tj 0.18 Tw T* [(\023\030\024\016\r\035\036\027\017\005, )0.6(\027\026\030\026\f\021\026\027\017\017 )0.5(\035\026\002\024\030\026\021\024\030\027\t\b )0.6(\023\024\022\026\026\021\036\035\036\005 )]TJ 0.466 Tw T* (\017\035\017 \024\021\f\031\021\f\021\r\017\017 \023\030\017\027\026\022\ \024\r \031\n\036\027\034\001\036\027\017\016 \030\026\n\036\030\024\r \ )Tj 0.01 Tw 0 -1.218 TD (\026\002\f\006\036\f\f\026 \027\026)Tj /Span<>> BDC ( )Tj EMC (\235\024\027\036 \n\036\007\017\022\026\n\036\027\021\024\027\024\005 \021\ \036\030\026\023\017\017, \f\035\036\007\031\036\021 )Tj 0 Tw 0 -1.218 TD (\030\026\f\f\n\026\021\030\017\r\026\021\034 \r\024\023\030\024\f \024)Tj /Span<>> BDC ( )Tj EMC (\b\017\030\031\030\020\017\004\036\f\022\024\n \035\036\004\036\027\017\017\ .)Tj 0.092 Tw 0 -1.218 TD [(\200 \024\007\027\024\n \030\036\021\030\024\f\023\036\022\021\017\r\027\ \024\n )0.5(\017\f\f\035\036\007\024\r\026\027\017\017 )0.5([61] 32 \023\026)]TJ 0 Tw (-)Tj 0.063 Tw T* (\006\017\036\027\021\026 \035\036\004\017\035\017 \021\024\035\034\022\024\ \026\027\021\017\002\017\024\021\017\022\026\n\017 \017-\026 \021\036\ \b\027\017\004\036)Tj 0 Tw (-)Tj 0.024 Tw T* (\f\022\024\005 \027\036\r\024\n\024\032\027\024\f\021\017 \232\025\212 \ \017\035\017 \023\030\036\007\023\024\004\021\036\027\017\016 \b\017\030\ \031\030\020\026, )Tj 0.155 Tw T* (\026)Tj /Span<>> BDC ( )Tj EMC 0.85 0 Td [(114 )0.5(\r\t\023\024\035\027\017\035\017 )0.6(\232\025\212 )0.5(\(\r )0.5(\024\002\036\017\b )0.5(\020\030\031\023\023\026\b )0.6(\007\017\r\036\030\021\017\022\031)]TJ 0 Tw (-)Tj 0.103 Tw -0.85 -1.218 Td (\035\016\030\027\t\036 \026\002\f\006\036\f\f\t \002\t\035\017)Tj /Span<>> BDC ( )Tj EMC (\234)Tj /Span<>> BDC ( )Tj EMC (3 \f\n \r)Tj /Span<>> BDC ( )Tj EMC (\007\017\026\n\036\021\030\036\). \224\030\024\004\027\026\016 )Tj 0.379 Tw T* (\024\023\036\030\026\006\017\016 \023\024\021\030\036\002\024\r\026\035\026\ \f\034 \r)Tj /Span<>> BDC ( )Tj EMC (8)Tj /Span<>> BDC ( )Tj EMC (\(25%\) \027\026\002\035\033\007\036\027\017\016\b )Tj -0.047 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\f\r\016\017 \f)Tj /Span<>> BDC ( )Tj EMC (\f\024\b\030\026\027\016\033\013\017\n\017\f\016 \f\017\n\023\021\024\n\026\ \n\017 \027\026)Tj /Span<>> BDC ( )Tj EMC (\235\024\027\036 \026\027\021\017)Tj 0 Tw (-)Tj -0.025 Tw T* (\002\017\024\021\017\022\024\021\036\030\026\023\017\017 \017)Tj /Span<>> BDC ( )Tj EMC (\r 21)Tj /Span<>> BDC ( )Tj EMC (\(18%\))Tj /Span<>> BDC ( )Tj EMC (\227 \023\024\f\035\036 \232\025\212 \()Tj /T1_1 1 Tf 0 Tw (\033)Tj /T1_0 1 Tf -0.025 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,21\). )Tj 0.215 Tw T* (\211)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \023\036\030\r\024\005 \020\030\031\023\ \023\t \007\017\026\n\036\021\030 \026\002\f\006\036\f\f\026 \002\t\035 \ )Tj 0.012 Tw T* (\n\036\027\034\001\036 \(5,9 \023\030\024\021\017\r 7,1 \f\n, )Tj /T1_1 1 Tf 0 Tw (\033)Tj /T1_0 1 Tf 0.012 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,001\), \002\024\035\036\036 \022\024\030\024\021\022\017\005 )Tj 0.069 Tw T* (\017\027\021\036\030\r\026\035 \n\036\032\007\031 \023\036\030\r\024\027\ \026\004\026\035\034\027\t\n \035\036\004\036\027\017\036\n \017)Tj /Span<>> BDC ( )Tj EMC (\f\017\020\n\024)Tj 0 Tw (-)Tj 0.044 Tw T* (\017\007\220\022\021\024\n\017\036\005 \(\r \f\030\036\007\027\036\n, 50\ \023\030\024\021\017\r 80 \007\027\036\005, )Tj /T1_1 1 Tf 0 Tw (\033)Tj /T1_0 1 Tf 0.044 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,02\), )Tj 0.081 Tw T* (\023\024\f\035\036\024\023\036\030\026\006\017\024\027\027\t\036 \024\f\035\ \024\032\027\036\027\017\016 \023\024\f\035\036 \021\024\035\034\022\024\ \026\027\021\017)Tj 0 Tw (-)Tj 0.045 Tw T* [(\002\017\024\021\017\022\024\021\036\030\026\023\017\017 )0.5(\002\t\035\017 )0.5(\002\024\035\036\036 \035\036\020\022\017\n\017, )0.5(\004\036\n \023\024\f\035\036 \232\025\212 )]TJ 0 Tw T* (\023\024)Tj /Span<>> BDC ( )Tj EMC [(\022\035\026\f\f\017\235\017\022\026\006\017\017 Cl)-15.9(av)-15.9(ien-Dind)-16(o \()]TJ /T1_1 1 Tf (\033)Tj /T1_0 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,04\).)Tj -0.045 Tw T* (\211 \023\026\006\017\036\027\021\024\r \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\022\035\017\027\017\004\036\f\022\024\n \031\035\031\004\001\036\027\017\ \017, \007\030\036\027\026\032\027\t\005 )Tj 0.104 Tw T* (\022\026\021\036\021\036\030 \031\007\026\035\016\035\017 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\f\031\013\036\f\021\r\036\027\027\024\n \f\024\022\030\026\013\036\027\017\ \017 \017\035\017 )Tj 0 Tw T* (\023\024\035\027\024\n \023\030\036\022\030\026\013\036\027\017\017 \024\ \021\007\036\035\016\036\n\024\020\024.)Tj 0.184 Tw T* (\200 \f\024\n\027\017\021\036\035\034\027\t\b \f\035\031\004\026\016\b \023\ \036\030\036\007 \031\007\026\035\036\027\017\036\n \007\030\036\027\026\ \032\026 )Tj 0.13 Tw T* (\023\030\024\r\024\007\017\035\024\f\034 \025\230 \f)Tj /Span<>> BDC ( )Tj EMC (\r\024\007\024\030\026\f\021\r\024\030\017\n\t\n \022\024\027\021\030\026\ \f\021\024\n \004\036)Tj 0 Tw (-)Tj 0.074 Tw T* (\030\036 \007\030\036\027\026\032\027\t\005 \022\026\021\036\021\036\030\ . \025\026\021\036\021\036\030 \017\r\035\036\022\026\035\f\016 \023\030\ \017)Tj /Span<>> BDC ( )Tj EMC (\017\f)Tj 0 Tw (-)Tj -0.064 Tw T* (\004\036\027\024\r\036\027\017\017 \026\021\036\022\026, \026)Tj /Span<>> BDC ( )Tj EMC (\023\030\017 \036\020\024 \027\026\035\017\004\017\017 \030\026\f\f\n\026\ \021\030\017\r\026\035\f\016 )Tj -0.037 Tw T* (\r\024\023\030\024\f \024)Tj /Span<>> BDC ( )Tj EMC (\023\024\r\021\024\030\027\024\n \007\030\036\027\017\030\024\r\026\027\017\ \017 \017\035\017 \024)Tj /Span<>> BDC ( )Tj EMC (\r\t\023\024\035\027\036\027\017\017 )Tj 0 Tw T* (\b\017\030\031\030\020\017\004\036\f\022\024\020\024 \r\n\036\001\026\021\ \036\035\034\f\021\r\026.)Tj -0.002 Tc 0.117 Tw T* (\214\024\022\026\035\017\024\r\026\027\027\t\005 \026\002\f\006\036\f\f\ \017\027\024\020\007\026 \n\024\032\036\021 \002\t\021\034 \023\030\024\ \016\r)Tj 0 Tc 0 Tw (-)Tj -0.002 Tc 0.172 Tw T* [(\035\036\027\017\036\n \035\024\022\026\004\036\f\021\r\036\027\027\024\ \005 \024\023\031\b\024\035\017 \024\002\024\007\024\004\027\024\005 \022\ \017\001\022\017)-2( )]TJ -0.029 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC [(\n\024\032\036\021 \017\n\017\021\017\030\024\r\026\021\034 \024\f\035\024\ \032\027\036\027\027\031\033 \007\017\r\036\030\021\017\022\031\035\016\030\ \027\031\033)-2( )]TJ 0.015 Tw T* (\002\024\035\036\027\034 \024\002\024\007\024\004\027\024\005 \022\017\001\ \022\017 \(\212\207\210\025\) [62]. \215\024\f\035\036 \220\023\017\024\ )Tj 0 Tc 0 Tw (-)Tj -0.002 Tc 0.133 Tw T* [(\007\026 \210\212 1468 \023\026\006\017\036\027\021\026\n \023\030\024\r\ \036\035\017 \022\024\035\024\027\024\f\022\024\023\017\033 [63]:)-2( )]TJ 0.012 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC [(1,16% \(95% \212\236 0,72\2261,9%\) \002\t\035 \007\017\026\020\027\024\f\ \021\017\030\024\r\026\027 \030\026\022)-2( )]TJ 0.045 Tw T* (\024\002\024\007\024\004\027\024\005 \022\017\001\022\017, \r)Tj /Span<>> BDC ( )Tj EMC (10,6%)Tj /Span<>> BDC ( )Tj EMC (\227 \020\017\023\036\030\023\035\026\f\021\017\004\036\f\022\017\036 \023\ \024)Tj 0 Tc 0 Tw (-)Tj -0.002 Tc -0.029 Tw T* (\035\017\023\t, \r)Tj /Span<>> BDC ( )Tj EMC (8,3%)Tj /Span<>> BDC ( )Tj EMC (\227 \026\007\036\027\024\n\026. \202\r\021\024\030\t \023\024\035\026\020\ \026\033\021, \004\021\024 \030\031\021\017\027)Tj 0 Tc 0 Tw (-)Tj -0.002 Tc 0.244 Tw T* (\027\026\016 \022\024\035\024\027\024\f\022\024\023\017\016 \023\030\017\ )Tj /Span<>> BDC ( )Tj EMC (\024\021\f\031\021\f\021\r\017\017 \007\030\031\020\017\b \022\035\017\027\ \017\004\036)Tj 0 Tc 0 Tw (-)Tj -0.002 Tc T* (\f\022\017\b \023\030\017\027\026\022\024\r \030\026\022\026 \027\036 \021\ \030\036\002\031\036\021\f\016 \023\024\f\035\036 \220\023\017\024\007\026\ \210\212.)Tj 0 Tc 0.019 Tw T* (\200 \022\026\004\036\f\021\r\036 \026\035\034\021\036\030\027\026\021\017\ \r\t \030\036\036\022\006\017\017 \024\002\024\007\024\004\027\024\005 \ \022\017\001\022\017 )Tj 0.1 Tw T* (\023\030\017)Tj /Span<>> BDC ( )Tj EMC (\024\f\035\024\032\027\036\027\027\024\n \210\212 \027\036\022\024\021\024\ \030\t\036 \026\r\021\024\030\t \023\030\036\007\035\026\020\026\033\021\ )Tj 0.224 Tw T* (\n\017\027\017\n\026\035\034\027\024 \017\027\r\026\017\r\027\t\005 \023\ \024\007\b\024\007 \f)Tj /Span<>> BDC ( )Tj EMC (\017\f\023\024\035\034\024\r\026\027\017\036\n )Tj 0.55 Tw T* [(\035\026\023\026\030\024\f\022\024\023\017\004\036\f\022\024\005 )0.6(\026\f\023\017\030\026\006\017\017 )0.6(\020\027\024\016, )0.5(\023\030\024\n\t\r\026\027\017\036 )]TJ 0.271 Tw T* (\002\030\033\001\027\024\005 \023\024\035\024\f\021\017 \017)Tj /Span<>> BDC ( )Tj EMC (\031\f\021\026\027\024\r\022\031 \007\030\036\027\026\032\036\005 \r)Tj /Span<>> BDC ( )Tj EMC (\002\030\033\001)Tj 0 Tw (-)Tj 0.157 Tw T* (\027\031\033 \023\024\035\024\f\021\034 \027\026)Tj /Span<>> BDC ( )Tj EMC (\007\024\f\021\026\021\024\004\027\024 \007\035\017\021\036\035\034\027\t\ \036 \f\030\024\022\017 [64]. )Tj 0.365 Tw 23.244 64.543 Td (\200)Tj /Span<>> BDC ( )Tj EMC (\007\030\031\020\024\n \017\f\f\035\036\007\024\r\026\027\017\017, \r\022\ \035\033\004\026\r\001\036\n 38 \002\024\035\034\027\t\b )Tj 0.072 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\030\026\035\017\021\t\n \023\036\030\017\021\024\027\017\021\024\n, \002\ \t\035\017 \024\021\n\036\004\036\027\t \027\036\031\007\024\r\035\036\021\ )Tj 0 Tw (-)Tj 0.137 Tw T* (\r\024\030\017\021\036\035\034\027\t\036 \030\036\031\035\034\021\026\021\ \t [65], \026\r\021\024\030\t \023\030\017\001\035\017 \022)Tj /Span<>> BDC ( )Tj EMC (\r\t)Tj 0 Tw (-)Tj 0.34 Tw T* (\r\024\007\031, \004\021\024 \024\021\002\024\030 \023\026\006\017\036\027\ \021\024\r \017\n\036\036\021 \023\036\030\r\024\f\021\036\023\036\027\027\ \024\036 )Tj -0.026 Tw T* (\027\026\004\036\027\017\036, \026)Tj /Span<>> BDC ( )Tj EMC (\r\t\016\r\035\036\027\017\036 \016\r\027\024\005 \023\036\030\235\024\030\ \026\006\017\017 \024\002\024\007\024\004\027\024\005 )Tj 0 Tw T* (\022\017\001\022\017)Tj /Span<>> BDC ( )Tj EMC (\227 \030\036\001\026\033\013\036\036 \027\026\004\036\027\017\036.)Tj 0.052 Tw 0 -1.218 TD [(\200 \217\025\236 DIL)-35(AL)-34.9(A, \023\024\f\035\036 \007\017\026\020\027\024\f\021\017\004\036\f\022\024\ \005 \035\026\023\026\030\024\f\022\024\023\017\017 )]TJ 0.091 Tw 0 -1.218 TD (\017)Tj /Span<>> BDC ( )Tj EMC (\r\t\016\r\035\036\027\017\017 \210\210\212 \023\024)Tj /Span<>> BDC ( )Tj EMC (Hinch\036y 3, \023\030\024\r\024\007\017\035\026\f\034 \030\026\027\007\024\ )Tj 0 Tw (-)Tj 0.193 Tw T* (\n\017\026\006\017\016 \n\036\032\007\031 \035\026\r\026\032\036\n \017\ )Tj /Span<>> BDC ( )Tj EMC (\030\036\036\022\006\017\036\005 [66], \004\026\f\021\024\021\026 )Tj 0.029 Tw T* (\024\f\035\024\032\027\036\027\017\005 \017)Tj /Span<>> BDC ( )Tj EMC (\035\036\021\026\035\034\027\024\f\021\034 \r)Tj /Span<>> BDC ( )Tj EMC (\007\r\031\b \020\030\031\023\023\026\b \027\036 \024\021\035\017\004\026\ )Tj 0 Tw (-)Tj 0.095 Tw T* (\035\017\f\034, \035\026\r\026\032 \023\030\017\r\036\035 \022)Tj /Span<>> BDC ( )Tj EMC (\f\024\022\030\026\013\036\027\017\033 \023\030\024\007\024\035\032\017\021\ \036\035\034\027\024)Tj 0 Tw (-)Tj -0.03 Tw T* (\f\021\017 \024\023\036\030\026\006\017\017, \f\030\024\022\024\r \027\026\ \b\024\032\007\036\027\017\016 \r)Tj /Span<>> BDC ( )Tj EMC (\210\217\236\230 \017)Tj /Span<>> BDC ( )Tj EMC (\f\021\026\006\017\024\027\026)Tj 0 Tw (-)Tj 0 -1.218 TD (\030\036 \026)Tj /Span<>> BDC ( )Tj EMC (\f\004\036\021 \024\021\f\031\021\f\021\r\017\016 \f\021\024\n\t.)Tj -0.01 Tw 0 -1.218 TD [(\200 \007\030\031\020\024\n \017\f\f\035\036\007\024\r\026\027\017\017 S\ C)20(A)51(N-DIV [67] \017\f\023\024\035\034\024\r\026\027\017\036 )]TJ 0.029 Tw 0 -1.218 TD (\035\026\023\026\030\024\f\022\024\023\017\004\036\f\022\024\020\024 \035\ \026\r\026\032\026 \023\024)Tj /Span<>> BDC ( )Tj EMC (\f\030\026\r\027\036\027\017\033 \f)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\r\017\004)Tj 0 Tw (-)Tj 0.194 Tw T* (\027\024\005 \030\036\036\022\006\017\036\005 \027\036 \f\027\017\017\035\ \024 \004\026\f\021\024\021\031 \021\016\032\036\035\t\b \023\024\f\035\036\ )Tj 0 Tw (-)Tj 0.116 Tw T* (\024\023\036\030\026\006\017\024\027\027\t\b \024\f\035\024\032\027\036\027\ \017\005 \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\017\r\036\035\024 \022)Tj /Span<>> BDC ( )Tj EMC (\b\031\007\001\017\n \030\036)Tj 0 Tw (-)Tj 0.095 Tw T* (\031\035\034\021\026\021\026\n. \230\026\022\017\036 \032\036 \030\036\ \031\035\034\021\026\021\t \002\t\035\017 \023\024\035\031\004\036\027\t\ \036\013\036 )Tj 0.152 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC [(\024\007\027\024\n \017\f\f\035\036\007\024\r\026\027\017\017 L)-35(ADIES [68]. \200)]TJ /Span<>> BDC ( )Tj EMC (\021\024 \032\036 \r\030\036\n\016, )Tj 0.099 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\030\016\007\036 \n\036\021\026\026\027\026\035\017\024\r \002\t\035\024\ \023\024\022\026\026\027\024, \004\021\024 \023\024)Tj /Span<>> BDC ( )Tj EMC (\f\030\026\r\027\036)Tj 0 Tw (-)Tj 0.399 Tw T* (\027\017\033 \f)Tj /Span<>> BDC ( )Tj EMC [(\220\022\f\021\030\036\027\027\024\005 )0.5(\030\036\036\022\006\017\036\005, \035\026\023\026\030\024\f\022\024\023\ \017\004\036\f\022\017\005 )]TJ 0.028 Tw T* (\035\026\r\026\032 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\210\210\212 \023\024)Tj /Span<>> BDC ( )Tj EMC (Hinch\036y 3 \007\036\n\024\027\f\021\030\017\030\031\036\021 \f\024\023\ \024\f\021\026)Tj 0 Tw (-)Tj 0.013 Tw T* (\r\017\n\031\033 \035\036\021\026\035\034\027\024\f\021\034, \027\024 \f\ \r\016\026\027 \f)Tj /Span<>> BDC ( )Tj EMC (\031\r\036\035\017\004\036\027\027\024\005 \023\024\021\030\036\002)Tj 0 Tw (-)Tj T* (\027\024\f\021\034\033 \r)Tj /Span<>> BDC ( )Tj EMC (\023\024\r\021\024\030\027\t\b \024\023\036\030\026\006\017\016\b [69,70\ ].)Tj 0.128 Tw T* (\203\026\017\002\024\035\036\036 \030\026\f\023\030\024\f\021\030\026\027\ \036\027\027\024\005 \024\023\036\030\026\006\017\036\005 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\235\024)Tj 0 Tw (-)Tj 0.403 Tw T* (\030\026\006\017\017 \007\017\r\036\030\021\017\022\031\035\026 \024\f\021\ \026\036\021\f\016 \030\036\036\022\006\017\016 \024\002\024\007\024\004\ \027\024\005 )Tj -0.02 Tw T* (\022\017\001\022\017 \023\024)Tj /Span<>> BDC ( )Tj EMC (\206\026\030\021\n\026\027\031 [71]. \200)Tj /Span<>> BDC ( )Tj EMC (\030\036\021\030\024\f\023\036\022\021\017\r\027\024\n \017\f\f\035\036\007\ \024)Tj 0 Tw (-)Tj 0.072 Tw T* (\r\026\027\017\017, \r\022\035\033\004\026\033\013\036\n 18543 \023\026\006\ \017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\r\t\n \220\023\017)Tj 0 Tw (-)Tj -0.029 Tw T* (\024\007\024\n \210\212, 3873 \023\036\030\036\027\036\f\035\017 \220\022\ \f\021\030\036\027\027\t\036 \b\017\030\031\030\020\017\004\036\f\022\017\ \036 )Tj 0.176 Tw T* (\r\n\036\001\026\021\036\035\034\f\021\r\026, \017)Tj /Span<>> BDC ( )Tj EMC (\027\017\b \024\023\036\030\026\006\017\016 \206\026\030\021\n\026\027\026\ \(\210\206\) \r\t)Tj 0 Tw (-)Tj T* (\023\024\035\027\036\027\026 \r)Tj /Span<>> BDC ( )Tj EMC (64% \027\026\002\035\033\007\036\027\017\005 [72].)Tj -0.012 Tc -0.005 Tw T* (\210\023\031\002\035\017\022\024\r\026\027\t \030\026\002\024\021\t, \f\030\ \026\r\027\017\r\026\033\013\017\036 \030\036\031\035\034\021\026\021\t\ \023\036\030)Tj 0 Tc 0 Tw (-)Tj -0.012 Tc 0.049 Tw T* (\r\017\004\027\024\005 \030\036\036\022\006\017\017 \f)Tj /Span<>> BDC ( )Tj EMC (\235\024\030\n\017\030\024\r\026\027\017\036\n \026\027\026\f\021\024\n\024\ \026 \017)Tj /Span<>> BDC ( )Tj EMC (\023\036\021)Tj 0 Tc 0 Tw (-)Tj -0.012 Tc 0.096 Tw T* [(\035\036\r\024\005 )0.5(\023\030\036\r\036\027\021\017\r\027\024\005 )0.5(\f\021\024\n\t )0.5(\017\035\017 )0.5(\002\036 \027\036\036 \023\030\017)]TJ /Span<>> BDC ( )Tj EMC [(\210\212, )0.5(\007\026\032\036)-12( )]TJ 0.018 Tw T* (\023\030\017)Tj /Span<>> BDC ( )Tj EMC (\027\026\035\017\004\017\017 \007\017\235\235\031\027\024\020\024 \023\036\ \030\017\021\024\027\017\021\026 [73], \026)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\032\036 \017\f)Tj 0 Tc 0 Tw (-)Tj -0.012 Tc -0.043 Tw T* (\b\024\007\t \210\206 \017)Tj /Span<>> BDC ( )Tj EMC (\030\036\036\022\006\017\005 \f)Tj /Span<>> BDC ( )Tj EMC [(\235\024\030\n\017\030\024\r\026\027\017\036\n \026\027\026\f\021\024\n\024\ \026 [74].)-12( )]TJ 0.009 Tw T* (\224\031\013\036\f\021\r\036\027\027\t\b \030\026\035\017\004\017\005 \r\ )Tj /Span<>> BDC ( )Tj EMC (\004\026\f\021\024\021\036 \024\f\035\024\032\027\036\027\017\005 \017)Tj /Span<>> BDC ( )Tj EMC (\031\030\024\r)Tj 0 Tc 0 Tw (-)Tj -0.012 Tc 0.247 Tw T* (\027\036 \035\036\021\026\035\034\027\024\f\021\017 \027\036 \024\002\027\ \026\030\031\032\036\027\024. \215\024)Tj /Span<>> BDC ( )Tj EMC [(\007\026\027\027\t\n \030\026\002\024\021\t,)-12( )]TJ 0.267 Tw T* (\r\022\035\033\004\026\033\013\036\005 2729 \023\026\006\017\036\027\021\ \024\r \f)Tj /Span<>> BDC ( )Tj EMC (\210\210\212, \021\024\035\034\022\024 \031)Tj /Span<>> BDC ( )Tj EMC [(7,6%)-12( )]TJ 0.13 Tw T* (\002\024\035\034\027\t\b \002\t\035\026 \r\t\023\024\035\027\036\027\026\ \023\036\030\r\017\004\027\026\016 \030\036\036\022\006\017\016 \f)Tj /Span<>> BDC ( )Tj EMC (\026\027\026)Tj 0 Tc 0 Tw (-)Tj -0.012 Tc 0.169 Tw T* (\f\021\024\n\024\024\n, \r)Tj /Span<>> BDC ( )Tj EMC [(\024\f\021\026\035\034\027\t\b \027\026\002\035\033\007\036\027\017\016\b\ \023\030\024\017\r\036\007\036\027\026 \210\206)-12( )]TJ 0.004 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\017\035\036\024\f\021\024\n\017\036\005 [75]. \211)Tj /Span<>> BDC ( )Tj EMC [(\023\026\006\017\036\027\021\024\r, \023\036\030\036\027\036\f\001\017\b\ \210\206, \004\026\013\036)-12( )]TJ 0.268 Tw T* (\017\n\036\035\017\f\034 \f\024\023\031\021\f\021\r\031\033\013\017\036 \ \026\002\024\035\036\r\026\027\017\016 \(\216\210\207\214, \031)Tj /Span<>> BDC ( )Tj EMC [(9,8%)-12( )]TJ -0.052 Tw T* (\023\030\024\021\017\r 4,8%, )Tj /T1_1 1 Tf 0 Tc 0 Tw (\033)Tj /T1_0 1 Tf -0.012 Tc -0.052 Tw /Span<>> BDC 5.675 0 Td ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC 0.825 0 Td [(0,017\), \024\027\017 )0.5(\002\t\035\017 )0.5(\002\024\035\036\036 )0.5(\235\031\027\022\006\017\024\027\026\035\034\027\024)-12( )]TJ 0.08 Tw -6.5 -1.218 Td (\026\r\017\f\017\n\t \(6,3% \023\030\024\021\017\r 2,4%, )Tj /T1_1 1 Tf 0 Tc 0 Tw (\033)Tj /T1_0 1 Tf -0.012 Tc 0.08 Tw /Span<>> BDC 12.725 0 Td ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC [(0,025\), \027\026\002\035\033\007\026\035\017\f\034)-12( )]TJ 0.101 Tw -12.725 -1.218 Td (\024\f\035\024\032\027\036\027\017\016)Tj /Span<>> BDC ( )Tj EMC [(\227 \f\036\023\021\017\004\036\f\022\017\005 \001\024\022 \(11,1% \023\030\ \024\021\017\r 5,3%,)-12( )]TJ /T1_1 1 Tf 0 Tc 0 Tw T* (\033)Tj /T1_0 1 Tf -0.012 Tc 0.016 Tw /Span<>> BDC 0.466 0 Td ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC [(0,15\). \214\036\021\026\035\034\027\024\f\021\034 \023\024\f\035\036 \210\ \206 \f\024\f\021\026\r\017\035\026 7,6% \023\030\024\021\017\r)-12( )]TJ 0.199 Tw -0.466 -1.218 Td (2,9% \023\024\f\035\036 \023\036\030\r\017\004\027\024\005 \030\036\036\ \022\006\017\017 \()Tj /T1_1 1 Tf 0 Tc 0 Tw (\033)Tj /T1_0 1 Tf -0.012 Tc 0.199 Tw /Span<>> BDC 14.845 0 Td ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,011\), \024\f\035\024\032)Tj 0 Tc 0 Tw (-)Tj -0.012 Tc 0.143 Tw -14.845 -1.218 Td (\027\036\027\017\016)Tj /Span<>> BDC ( )Tj EMC (\227 55,4% \017)Tj /Span<>> BDC ( )Tj EMC (48,6%, \f\024\024\021\r\036\021\f\021\r\036\027\027\024 \()Tj /T1_1 1 Tf 0 Tc 0 Tw (\033)Tj /T1_0 1 Tf -0.012 Tc 0.143 Tw /Span<>> BDC 18.114 0 Td ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC [(0,056\).)-12( )]TJ 0.051 Tw -18.114 -1.218 Td (\215\030\017)Tj /Span<>> BDC ( )Tj EMC [(\023\030\024\r\036\007\036\027\017\017 \n\027\024\020\024\235\026\022\021\ \024\030\027\024\020\024 \026\027\026\035\017\026 \024\022\026\026\035\ \024\f\034,)-12( )]TJ 0.347 Tw T* (\004\021\024 \023\036\030\r\017\004\027\t\005 \026\027\026\f\021\024\n\024\  \f)Tj /Span<>> BDC ( )Tj EMC [(\023\036\021\035\036\r\024\005 \017\035\036\024\f\021\024\n\017\036\005)-12( )]TJ 0.049 Tw T* (\023\024)Tj /Span<>> BDC ( )Tj EMC 1.247 0 Td [(\f\030\026\r\027\036\027\017\033 )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC [(\210\206 )0.5(\027\036)]TJ /Span<>> BDC ( )Tj EMC (\023\030\017\r\036\035 \022)Tj /Span<>> BDC ( )Tj EMC 11.727 0 Td [(\031\r\036\035\017\004\036\027\017\033 )0.5(\035\036\021\026\035\034\027\024)]TJ 0 Tc 0 Tw (-)Tj -0.012 Tc -0.037 Tw -12.974 -1.218 Td [(\f\021\017 )0.6(\(\210\217 )0.6(0,21; )0.6(95% )0.6(\212\236 )0.6(0,03\2261,58, )]TJ /T1_1 1 Tf 0 Tc 0 Tw 12.649 0 Td (\033)Tj /T1_0 1 Tf -0.012 Tc -0.037 Tw /Span<>> BDC 0.466 0 Td ( )Tj EMC 0.183 0 Td (=)Tj /Span<>> BDC ( )Tj EMC 0.671 0 Td [(0,129\) )0.6(\017\035\017 )0.5(\024\f\035\024\032\027\036)]TJ 0 Tc 0 Tw (-)Tj -0.012 Tc -13.969 -1.218 Td (\027\017\005 \(\210\217 0,96; 95% \212\236 0,63\2261,45, )Tj /T1_1 1 Tf 0 Tc (\033)Tj /T1_0 1 Tf -0.012 Tc /Span<>> BDC 13.552 0 Td ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,834\).)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0 Tc 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\206)10(\002\036\033 \035\030\032\003\033)30(\n)42(\032)-21(\230\033\241)]TJ 57.136 0 Td (REVIEW)Tj -57.136 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 2)69(4, \023\0224, 202)23(5)]TJ 43.013 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 2)69(4, \023\0224, 202)23(5)]TJ /T1_3 1 Tf 25 0 0 25 21.6903 56.0378 Tm (204)Tj ET endstream endobj 549 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\006\025\222\201\025\b\220 \211\021\001\202\215\025\b)-10(\026\021\017\021 \021\022\t\016\f\016\215\021\004 \025\b)-9.9(\026\201\025\202)10(\025 \211\021\r\016\201\026\021\017\200\t\021\026)11(\001 )]TJ 0 -1 TD [(\025\235\025\211\025\f\215\025\207 \017\021\020\017\021 \(\025\235\213\025\ \201 \t\021\026)11(\016\201\001\026)-20(\200\201\220\))]TJ 43.987 1 Td [(Issues of\022diagnosis and tr)31.1(eatment of\022acute )]TJ 3.463 -1 Td [(div)12(er)-20(ticulitis of\022th)11(e colon \(r)31(e)11(vie)11(w\))]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0.143 Tw 10 0 0 10 42.5197 724.8299 Tm (\215\030\017 \f\024\023\024\f\021\026\r\035\036\027\017\017 \031\030\024\ \r\027\016 \224\217\207 \f)Tj /Span<>> BDC ( )Tj EMC (\007\026\027\027\t\n\017 \025\230 \002\t\035\024 )Tj 0.149 Tw 0 -1.218 TD (\023\024\022\026\026\027\024, \004\021\024 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\210\210\212 \023\024)Tj /Span<>> BDC ( )Tj EMC (Hinch\036y 1\026/1b \002\t\035\017 \035\036\020)Tj 0 Tw (-)Tj 0.353 Tw T* (\022\017\036 \025\230-\007\026\027\027\t\036, \023\030\017)Tj /Span<>> BDC ( )Tj EMC (Hinch\036y 3/4)Tj /Span<>> BDC ( )Tj EMC (\227 \r\t\030\026\032\036\027\027\t\036 )Tj 0.403 Tw T* (\025\230-\007\026\027\027\t\036 \017, \f\024\024\021\r\036\021\f\021\r\036\ \027\027\024, \023\024\022\026\026\021\036\035\017 \224\217\207 80 )Tj 0.112 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (258,5)Tj /Span<>> BDC ( )Tj EMC (\n\020/\035 \()Tj /T1_2 1 Tf 0 Tw (\033)Tj /T1_1 1 Tf 0.112 Tw /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (0,001\) [30]. \200)Tj /Span<>> BDC ( )Tj EMC (\021\024\032\036 \r\030\036\n\016, \026\r\021\024\030\t )Tj -0.022 Tw T* (\023\030\017\001\035\017 \022)Tj /Span<>> BDC ( )Tj EMC (\r\t\r\024\007\031, \004\021\024 \031\030\024\r\036\027\034 \224\217\207\ \027\036 \f\035\036\007\031\036\021 \017\f\023\024\035\034)Tj 0 Tw (-)Tj 0.073 Tw 0 -1.218 TD (\024\r\026\021\034 \r)Tj /Span<>> BDC ( )Tj EMC (\022\026\004\036\f\021\r\036 \023\030\036\007\017\022\021\024\030\026 \021\ \016\032\036\f\021\017, \036\f\035\017 \017\n\036\036\021\f\016 )Tj 0.229 Tw 0 -1.218 TD [(\f\024\023\031\021\f\021\r\031\033\013\026\016 )0.5(\023\026\021\024\035\024\020\017\016, \022\024\021\024\030\026\016 \n\024\ \032\036\021 \023\024\r\035\017\016\021\034 )]TJ 0 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC (\036\020\024 \017\f\b\024\007\027\t\005 \031\030\024\r\036\027\034.)Tj -0.035 Tw T* [(\200\026\032\027\024 )0.5(\021\026\022\032\036 )0.5(\024\021\n\036\021\017\021\034, )0.5(\004\021\024 )0.5(\023\030\017)]TJ /Span<>> BDC ( )Tj EMC 12.786 0 Td [(\024\f\021\030\024\n )0.5(\027\026\004\026\035\036 )0.6(\026\002\024\035\036)]TJ 0 Tw (-)Tj 0.082 Tw -12.786 -1.218 Td (\r\026\027\017\016 \027\026\004\036\027\017\036 \224\217\207 \n\024\032\ \036\021 \036\013\036 \027\036 \023\024\r\t\001\026\021\034\f\016, \031\030\ \024)Tj 0 Tw (-)Tj 0.09 Tw T* (\r\036\027\034 \224\217\207 \007\024\f\021\017\020\026\036\021 \023\017\022\ \026 \004\036\030\036 48 \004., \017)Tj /Span<>> BDC ( )Tj EMC (\f\035\036\007\031\036\021 \023\030\024)Tj 0 Tw (-)Tj 0.025 Tw 0 -1.218 TD [(\016\r\035\016\021\034 )0.5(\024\f\021\024\030\024\032\027\024\f\021\034 \007\035\016 )0.5(\017\f\022\035\033\004\036\027\017\016 )0.5(\210\212 \023\030\017)]TJ /Span<>> BDC ( )Tj EMC (\027\017\022\024\n )Tj 0 Tw 0 -1.218 TD (\031\030\024\r\027\036 \224\217\207 [31].)Tj 0.264 Tw 0 -1.218 TD (\200 \007\r\031\b \f\017\f\021\036\n\026\021\017\004\036\f\022\017\b \024\ \002\024\030\026\b \(\026\027\026\035\017 8 \017\f\f\035\036)Tj 0 Tw (-)Tj 0.278 Tw T* (\007\024\r\026\027\017\005\) \002\t\035\024 \023\024\022\026\026\027\024\ , \004\021\024 \004\031\r\f\021\r\017\021\036\035\034\027\024\f\021\034 \ \025\230 )Tj 0.113 Tw T* (\023\030\017)Tj /Span<>> BDC ( )Tj EMC (\210\212 \002\t\035\026 \r\t\f\024\022\024\005 \(94% \(95% \212\236 87\226\ 97%\)\), \022\026\022 )Tj 0.128 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\f\023\036\006\017\235\017\004\027\024\f\021\034 \(99% \(95% \212\236 90\ \22699,9%\) [32,33]. )Tj 0.104 Tw T* (\203\036\024\002\b\024\007\017\n\024 \024\021\n\036\021\017\021\034, \004\ \021\024 \031)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\034\001\017\027\f\021\r\026 \023\026\006\017\036\027\021\024\ \r )Tj 0 Tw T* (\027\036 \002\t\035\024 \024\022\024\027\004\026\021\036\035\034\027\024\ \020\024 \(\b\017\030\031\030\020\017\004\036\f\022\024\020\024\) \007\017\ \026\020\027\024\026.)Tj 0.223 Tw T* [(\215\030\017 )0.5(\023\036\030\r\024\027\026\004\026\035\034\027\024\005 )0.6(\024\006\036\027\022\036 )0.6(\023\026\006\017\036\027\021\024\r )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC 18.366 0 Td (\023\024\007\024\030\036)Tj 0 Tw (-)Tj 0.179 Tw -18.366 -1.218 Td (\027\017\036\n \027\026)Tj /Span<>> BDC ( )Tj EMC (\210\212 \r\024\n\024\032\027\024 \017\f\023\024\035\034\024\r\026\027\ \017\036 \211\003\236, \022\024\021\024\030\024\036 )Tj 0.331 Tw T* [(\001\017\030\024\022\024 \030\026\f\023\030\024\f\021\030\026\027\036\027\ \024, \035\036\020\022\024\007\024\f\021\031\023\027\024, )0.5(\b\024\021\016 \007\026\027)]TJ 0 Tw (-)Tj 0.306 Tw T* (\027\t\005 \n\036\021\024\007 \016\r\035\016\036\021\f\016 \024\023\036\030\ \026\021\024\030-\026\r\017\f\017\n\t\n \n\036\021\024\007\024\n )Tj 0.448 Tw T* (\017\f\f\035\036\007\024\r\026\027\017\016 [34]. \210\020\030\026\027\017\ \004\036\027\017\016 \007\026\027\027\024\020\024 \n\036\021\024\007\026\ )Tj 0.101 Tw T* (\r\022\035\033\004\026\033\021 \023\035\024\b\031\033 \024\006\036\027\022\ \031 \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\024\032\017\030\036\027\017\036\n, )Tj 0.153 Tw T* (\f\035\024\032\027\024\f\021\034 \024\002\027\026\030\031\032\036\027\017\ \016 \f\r\024\002\024\007\027\024\020\024 \020\026\026 \017)Tj /Span<>> BDC ( )Tj EMC (\020\035\031\002\024\022\024 )Tj 0.238 Tw T* (\030\026\f\023\024\035\024\032\036\027\027\t\b \026\002\f\006\036\f\f\024\ \r [35]. \224\031\n\n\026\030\027\026\016 \024\006\036\027\022\026 )Tj 0.132 Tw T* (\004\031\r\f\021\r\017\021\036\035\034\027\024\f\021\017 \007\035\016 \211\ \003\236 \f\024\f\021\026\r\035\016\036\021 90% \(95% \212\236 )Tj 0.188 Tw T* (76\22698%\) \023\024)Tj /Span<>> BDC ( )Tj EMC (\f\030\026\r\027\036\027\017\033 \f)Tj /Span<>> BDC ( )Tj EMC (95% \(95% \212\236 90\226100%\), )Tj 0.056 Tw T* [(\f\024\024\021\r\036\021\f\021\r\036\027\027\024, )0.5(\()]TJ /T1_2 1 Tf 0 Tw (\033)Tj /T1_1 1 Tf 0.056 Tw /Span<>> BDC ( )Tj EMC 8.028 0 Td (=)Tj /Span<>> BDC ( )Tj EMC [(0,04\) )0.5([36]. )0.5(\216\024\021\016 \025\230)]TJ /Span<>> BDC ( )Tj EMC 8.887 0 Td (\227 \027\026\017\002\024\035\036\036 )Tj -0.015 Tw -16.915 -1.218 Td (\004\031\r\f\021\r\017\021\036\035\034\027\t\005 \n\036\021\024\007 \r\017\ \031\026\035\017\026\006\017\017, \023\024\220\021\026\023\027\t\005 \023\ \024\007)Tj 0 Tw (-)Tj 0.024 Tw T* (\b\024\007 \022)Tj /Span<>> BDC ( )Tj EMC (\025\230 \023\024\f\035\036 \027\036\024\023\030\036\007\036\035\036\027\ \027\024\020\024 \017\035\017 \024\021\030\017\006\026\021\036\035\034\027\ \024\020\024 )Tj 0.166 Tw T* (\211\003\236 \030\026\f\f\n\026\021\030\017\r\026\033\021 \022\026\022 \002\ \036\024\023\026\f\027\t\005 \017)Tj /Span<>> BDC ( )Tj EMC (\026\035\034\021\036\030\027\026\021\017\r)Tj 0 Tw (-)Tj T* (\027\t\005 \023\024\007\b\024\007 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\023\024\007\024\030\036\027\017\017 \027\026)Tj /Span<>> BDC ( )Tj EMC (\210\212 [36,37].)Tj 0.038 Tw T* (\204\026\020\027\017\021\027\024-\030\036\024\027\026\027\f\027\026\016\ \021\024\n\024\020\030\026\235\017\016 \(\204\217\230\) \007\024)Tj /Span<>> BDC ( )Tj EMC (\f\017\b \023\024\030 )Tj 0.161 Tw T* [(\021\030\031\007\027\024\r\t\023\024\035\027\017\n\026 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC [(\031\f\035\024\r\017\016\b \024\022\026\026\027\017\016 )0.5(\027\036\024\021\035\024\032\027\024\005 )]TJ 0.351 Tw T* (\n\036\007\017\006\017\027\f\022\024\005 \023\024\n\024\013\017 [38]. \202\ \n\036\030\017\022\026\027\f\022\024\005 \020\026\f\021\030\024)Tj 0 Tw (-)Tj 0.189 Tw T* [(\220\027\021\036\030\024\035\024\020\017\004\036\f\022\024\005 \026\f\f\024\ \006\017\026\006\017\036\005 \(A)16(GA\) \030\036\022\024\n\036\027\007\031\036\021)]TJ 0 Tw (-)Tj 0.23 Tw T* (\f\016 \017\f\023\024\035\034\024\r\026\021\034 \r\017\031\026\035\017\ \026\006\017\033 \007\035\016 \023\024\007\021\r\036\030\032\007\036\027\ \017\016 )Tj -0.001 Tw T* (\007\017\026\020\027\024\026 \210\212 [39], \r)Tj /Span<>> BDC ( )Tj EMC (\007\030\031\020\017\b \030\036\022\024\n\036\027\007\026\006\017\016\b \ \023\024\007\004\036\030\022\017)Tj 0 Tw (-)Tj 0.049 Tw T* (\r\026\036\021\f\016 \r\026\032\027\024\f\021\034 \023\030\024\r\036\007\ \036\027\017\016 \025\230 \017\035\017 \211\003\236 \007\035\016 \031\021\ \024\004\027\036)Tj 0 Tw (-)Tj -0.032 Tw T* (\027\017\016 \007\017\026\020\027\024\026 [40,41]. \200)Tj /Span<>> BDC ( )Tj EMC (\030\036\022\024\n\036\027\007\026\006\017\016\b \213\r\030\024\023\036\005\ \f\022\024\020\024 )Tj 0.218 Tw T* (\024\002\013\036\f\021\r\026 \022\024\035\024\023\030\024\022\021\024\035\ \024\020\024\r \(ESCP\) \021\026\022\032\036 \f\004\017\021\026\036\021\f\ \016, )Tj -0.002 Tw T* (\004\021\024 \r\017\031\026\035\017\026\006\017\016 \027\036\024\002\b\ \024\007\017\n\026 \007\035\016 \023\030\017\027\016\021\017\016 \030\036\ \001\036\027\017\016 )Tj -0.014 Tw T* (\024)Tj /Span<>> BDC ( )Tj EMC (\035\036\004\036\027\017\017 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\024\022\026\026\027\017\017 \022\026\022 \r\021\024\030\017\004\027\024\ \005, \021\026\022 \017)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\r\017\004)Tj 0 Tw (-)Tj 0.168 Tw T* (\027\024\005 \n\036\007\017\006\017\027\f\022\024\005 \023\024\n\024\013\ \017 [40]. \202\n\036\030\017\022\026\027\f\022\017\005 \022\024\035)Tj 0 Tw (-)Tj 0.048 Tw T* [(\035\036\007\032 \r\030\026\004\036\005 )0.5(\(\202\224\217\) )0.5(\023\030\036\007\035\026\020\026\036\021 )0.5(\025\230, \253\022\024\020\007\026 \f\031\013\036\f\021\r\031\036\021 )]TJ 0.049 Tw T* (\007\017\026\020\027\024\f\021\017\004\036\f\022\026\016 \027\036\024\023\ \030\036\007\036\035\036\027\027\024\f\021\034\273 [42]. \200)Tj /Span<>> BDC ( )Tj EMC (\024\021\035\017\004\017\036 )Tj 0.155 Tw T* (\024\021 \202\n\036\030\017\022\026\027\f\022\024\020\024 \024\002\013\036\ \f\021\r\026 \022\024\035\024\030\036\022\021\026\035\034\027\t\b \b\017\ \030\031\030)Tj 0 Tw (-)Tj 0.002 Tw T* [(\020\024\r \(A)35(SCRS\) [41], WSES \023\030\036\007\035\026\020\026\036\021 \023\024\220\021\ \026\023\027\t\005 \023\024\007\b\024\007, )]TJ -0.035 Tw T* (\027\026\004\017\027\026\016 \f)Tj /Span<>> BDC ( )Tj EMC (\024\002\f\035\036\007\024\r\026\027\017\016, \026)Tj /Span<>> BDC ( )Tj EMC (\027\036\n\036\006\022\017\036 \f\023\036\006\017\026\035\017\f\021\t \030\ \036)Tj 0 Tw (-)Tj -0.002 Tw T* (\022\024\n\036\027\007\031\033\021 \023\030\024\r\024\007\017\021\034 \r\ \017\031\026\035\017\026\006\017\033 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\023\024\007\024\030\036\027\017\017 )Tj 0 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC (\007\017\r\036\030\021\017\022\031\035\017\021 [43].)Tj 0.087 Tw 23.244 64.543 Td (\203\t\027\036\001\027\036\036 \024\021\027\024\001\036\027\017\036 \022\ )Tj /Span<>> BDC ( )Tj EMC (\r\017\031\026\035\017\026\006\017\017, \f\022\024\030\036\036 \r\f\036\ \020\024, )Tj 0.064 Tw T* (\017\n\036\027\017\021\f\016 \002\035\026\020\024\007\026\030\016 \023\024\ \007\007\036\030\032\022\036 \017\f\022\031\f\f\021\r\036\027\027\024\020\ \024 \017\027)Tj 0 Tw (-)Tj T* (\021\036\035\035\036\022\021\026 [44].)Tj 0.479 Tw T* (\202\027\021\017\002\017\024\021\017\022\017 \n\024\032\027\024 \002\036\ \024\023\026\f\027\024 \017\f\022\035\033\004\017\021\034 \031)Tj /Span<>> BDC ( )Tj EMC (\023\026)Tj 0 Tw (-)Tj 0.234 Tw T* (\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\r\t\n \220\023\017\024\007\024\n \024\f\035\024\032\027\036\ \027\027\024\020\024 \210\212 \(1\026 )Tj 0.294 Tw T* (\023\024)Tj /Span<>> BDC ( )Tj EMC (Hinch\036y\), \026\027\026\035\024\020\017\004\027\t\036 \030\036\031\035\ \034\021\026\021\t \002\t\035\017 \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\017 )Tj 0.05 Tw 0 -1.218 TD (\210\212 1b \023\024)Tj /Span<>> BDC ( )Tj EMC (Hinch\036y, \b\024\021\016 \026\r\021\024\030\t, \r\r\017\007\031 \024\020\ \030\026\027\017\004\036\027\027\024\020\024 )Tj -0.031 Tw 0 -1.218 TD (\004\017\f\035\026 \002\024\035\034\027\t\b, \f\004\017\021\026\033\021,\ \004\021\024 \027\026\002\035\033\007\026\021\036\035\034\027\024\036 \035\ \036\004\036\027\017\036 )Tj 0.014 Tw T* (\(\002\036 \026\027\021\017\002\017\024\021\017\022\024\r\) \007\024\035\ \032\027\024 \002\t\021\034 \024\020\030\026\027\017\004\036\027\024 \f\035\ \031\004\026\016)Tj 0 Tw (-)Tj T* (\n\017 1a \023\024)Tj /Span<>> BDC ( )Tj EMC (Hinch\036y [45].)Tj -0.002 Tc 0.322 Tw T* (\215\030\017 \r\027\031\021\030\017\r\036\027\027\024\n \035\036\004\036\ \027\017\017 \026\027\021\017\002\017\024\021\017\022\026\n\017 \031)Tj /Span<>> BDC ( )Tj EMC [(85%)-2( )]TJ 0.118 Tw T* (\002\024\035\034\027\t\b \f)Tj /Span<>> BDC ( )Tj EMC [(\210\212 )0.5(\002\t\035 \023\024\035\031\004\036\027 \b\024\030\024\001\017\005 \030\036\ \031\035\034\021\026\021 \f)]TJ /Span<>> BDC ( )Tj EMC (\004\026)Tj 0 Tc 0 Tw (-)Tj -0.002 Tc -0.009 Tw 0 -1.218 TD (\f\021\024\021\024\005 \030\036\006\017\007\017\r\024\r 2% \023\030\017)Tj /Span<>> BDC ( )Tj EMC [(\f\030\036\007\027\036\n \f\030\024\022\036 \027\026\002\035\033\007\036\ \027\017\016)-2( )]TJ 0.084 Tw 0 -1.218 TD (48 \n\036\f\016\006\036\r. \202\r\021\024\030\t \023\030\017\001\035\017\ \022)Tj /Span<>> BDC ( )Tj EMC (\r\t\r\024\007\031, \004\021\024 \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027)Tj 0 Tc 0 Tw (-)Tj -0.002 Tc 0.065 Tw 0 -1.218 TD [(\021\024\r \023\024\f\035\036 \021\026\022\024\020\024 \022\024\027\f\036\ \030\r\026\021\017\r\027\024\020\024 \035\036\004\036\027\017\016 \023\035\ \026\027\024\r\026\016)-2( )]TJ 0.24 Tw T* (\024\023\036\030\026\006\017\016 \027\036 \024\023\030\026\r\007\026\027\ \026 [46]. \200)Tj /Span<>> BDC ( )Tj EMC (\007\030\031\020\024\n \017\f\f\035\036\007\024\r\026)Tj 0 Tc 0 Tw (-)Tj -0.002 Tc 0.178 Tw T* (\027\017\017 \002\t\035\024 \023\024\022\026\026\027\024, \004\021\024 \ \026\027\021\017\002\017\024\021\017\022\017 \027\036 \024\002\016\026\021\ \036\035\034)Tj 0 Tc 0 Tw (-)Tj -0.002 Tc 0.107 Tw T* (\027\t \023\030\017)Tj /Span<>> BDC ( )Tj EMC [(\007\017\r\036\030\021\017\022\031\035\017\021\036 \035\036\020\022\024\005\ \f\021\036\023\036\027\017 \021\016\032\036\f\021\017 [47].)-2( )]TJ 0.034 Tw T* (\211)Tj /Span<>> BDC ( )Tj EMC (\020\024\f\023\017\021\026\035\017\017\030\024\r\026\027\027\t\b \002\024\ \035\034\027\t\b \035\036\004\036\027\017\036 \026\027\021\017\002\017\024\ \021\017)Tj 0 Tc 0 Tw (-)Tj -0.002 Tc 0.027 Tw T* (\022\026\n\017 \017\035\017 \002\036 \027\017\b \017\n\036\035\024 \f\024\ \023\024\f\021\026\r\017\n\t\036 \030\036\031\035\034\021\026\021\t)Tj /Span<>> BDC ( )Tj EMC [(\227)-2( )]TJ -0.04 Tw T* (\004\026\f\021\024\021\026 \030\036\006\017\007\017\r\024\r \017\035\017\ \023\024\f\035\036\007\031\033\013\017\b \024\023\036\030\026\006\017\005\ \f\024\f\021\026)Tj 0 Tc 0 Tw (-)Tj -0.002 Tc 0.069 Tw T* (\r\017\035\026 28% \017)Tj /Span<>> BDC ( )Tj EMC (29%, \f\024\024\021\r\036\021\f\021\r\036\027\027\024, \023\030\017)Tj /Span<>> BDC ( )Tj EMC [(\f\030\036\007\027\036\n \f\030\024\022\036)-2( )]TJ 0.048 Tw T* (\027\026\002\035\033\007\036\027\017\016 30 \n\036\f\016\006\036\r. \200\ )Tj /Span<>> BDC ( )Tj EMC (\021\024 \032\036 \r\030\036\n\016, \031)Tj /Span<>> BDC ( )Tj EMC [(\023\026\006\017\036\027\021\024\r,)-2.1( )]TJ 0.258 Tw T* [(\023\024\035\031\004\026\r\001\017\b \026\027\021\017\002\017\024\021\017\ \022\017, \002\t\035\017 \002\024\035\036\036 \r\t\030\026\032\036\027\027\ \t\036)-2( )]TJ -0.026 Tw T* [(\023\024\022\026\026\021\036\035\017 \r\024\f\023\026\035\036\027\017\016\ \(\035\026\002\024\030\026\021\024\030\027\t\036\), \022\035\017\027\017\ \004\036\f\022\017\036)-2( )]TJ 0 Tw T* (\023\030\024\016\r\035\036\027\017\016 \017)Tj /Span<>> BDC ( )Tj EMC (\027\026\004\017\021\036\035\034\027\t\036 \017\n\036\027\036\027\017\016\ \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\025\230 [48].)Tj 0 Tc 0.212 Tw T* (\204\036\021\026\026\027\026\035\017, \r\022\035\033\004\026\033\013\017\ \005 \021\024\035\034\022\024 \217\025\236, \023\024\022\026\026\035, \004\ \021\024 )Tj 0.239 Tw T* [(\023\035\026\027\024\r\026\016 \030\036\036\022\006\017\016 \f\017\020\n\ \024\r\017\007\027\024\005 )0.5(\022\017\001\022\017 \027\026\004\017\021\036\035\034)]TJ 0 Tw (-)Tj 0.221 Tw T* (\027\024 \004\026\013\036 \023\030\024\017\r\024\007\017\035\026\f\034 \ \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \027\026\002\035\033\007\036\027\017\016, \004\036\ \n )Tj 0.353 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \026\027\021\017\002\017\024\021\017\022\024\021\ \036\030\026\023\017\017 \(2,5% \023\030\024\021\017\r 0,9%, )Tj /T1_2 1 Tf 0 Tw T* (\033)Tj /T1_1 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,04\) [49].)Tj 0.016 Tw T* (\211\030\024\r\036\027\034 \035\036\021\026\035\034\027\024\f\021\017 \023\ \030\017)Tj /Span<>> BDC ( )Tj EMC (\210\212 \f\024\f\021\026\r\017\035 0,2% \(2 \f\035\031\004\026\016 )Tj 0.11 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC (1009 \002\024\035\034\027\t\b\) [50\22652]. \203\017 \024\007\027\024\n\031\ \017)Tj /Span<>> BDC ( )Tj EMC (208 \023\026\006\017)Tj 0 Tw (-)Tj 0.146 Tw T* (\036\027\021\024\r \027\036 \023\024\021\030\036\002\024\r\026\035\026\f\ \034 \220\022\f\021\030\036\027\027\026\016 \024\023\036\030\026\006\017\ \016 \027\036\026)Tj 0 Tw (-)Tj T* (\r\017\f\017\n\024 \024\021 \027\026\027\026\004\036\027\027\024\020\024\ \035\036\004\036\027\017\016 [50,53].)Tj 0.042 Tw T* (\200 \007\r\031\b \017\f\f\035\036\007\024\r\026\027\017\016\b \004\026\f\ \021\024\021\026 \r\t\023\024\035\027\036\027\017\016 \023\035\026\027\024\ \r\t\b )Tj -0.037 Tw T* [(\024\023\036\030\026\006\017\005 )0.5(\f\024\f\021\026\r\017\035\026 )0.5(4% )0.5(\(\r )0.5(\023\036\030\017\024\007 )0.6(\024\021 )0.5(8 )0.5(\007\024)]TJ /Span<>> BDC ( )Tj EMC 17.149 0 Td [(48 )0.5(\n\036\f\016\006\036\r\) )]TJ 0 Tw -17.149 -1.218 Td ([52,53] \017)Tj /Span<>> BDC ( )Tj EMC (12%)Tj /Span<>> BDC ( )Tj EMC (\227 \r)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\017\024\007 \007\024)Tj /Span<>> BDC ( )Tj EMC (55 \n\036\f\016\006\036\r [54].)Tj -0.008 Tw T* (\215\024 \030\036\031\035\034\021\026\021\026\n \n\036\021\026\026\027\026\ \035\017\026 [55] \027\036 \r\t\016\r\035\036\027\024 \030\026\035\017\ )Tj 0 Tw (-)Tj 0.035 Tw T* (\004\017\005 \r)Tj /Span<>> BDC ( )Tj EMC (\030\017\f\022\036 \r\t\023\024\035\027\036\027\017\016 \023\035\026\027\ \024\r\024\005 \024\023\036\030\026\006\017\017 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\026\n)Tj 0 Tw (-)Tj 0.223 Tw T* (\002\031\035\026\021\024\030\027\024\n \017)Tj /Span<>> BDC ( )Tj EMC (\f\021\026\006\017\024\027\026\030\027\024\n \035\036\004\036\027\017\017\ \(\210\217 0,76 [\212\236 )Tj 0.506 Tw T* (0,21\2262,77]\). \217\036\006\017\007\017\r \007\017\r\036\030\021\017\022\ \031\035\017\021\026 \027\026\002\035\033\007\026\036\021\f\016 )Tj 0.141 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (6,6%)Tj /Span<>> BDC ( )Tj EMC (\227 \004\036\030\036 8 \n\036\f\016\006\036\r [53] \017)Tj /Span<>> BDC ( )Tj EMC (\007\024 41%)Tj /Span<>> BDC ( )Tj EMC (\227 \004\036\030\036 )Tj 0 Tw T* (55)Tj /Span<>> BDC ( )Tj EMC (\n\036\f\016\006\036\r [54].)Tj 0.185 Tw T* (\215\030\017\n\036\030\027\024 \031)Tj /Span<>> BDC ( )Tj EMC (15\22620% \023\026\006\017\036\027\021\024\r, \023\024\f\021\031\023\017\ \r\001\017\b \f)Tj /Span<>> BDC ( )Tj EMC (\210\212, )Tj 0.273 Tw T* (\023\030\017)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\r\036\007\036\027\017\017 \025\230 \024\002\027\026\030\031\ \032\017\r\026\036\021\f\016 \026\002\f\006\036\f\f [56]. )Tj 0.148 Tw T* [(\214\036\004\036\027\017\036 \026\002\f\006\036\f\f\026 \021\030\036\002\ \031\036\021 \026\027\021\017\002\026\022\021\036\030\017\026\035\034\027\ \024\005 )0.5(\021\036\030\026)]TJ 0 Tw (-)Tj 0.118 Tw T* (\023\017\017, \036\f\035\017 \026\002\f\006\036\f\f \024\020\030\026\027\ \017\004\036\027 \023\024)Tj /Span<>> BDC ( )Tj EMC (\030\026\n\036\030\031, \f\017\f\021\036\n\027\026\016 )Tj 0.421 Tw T* [(\026\027\021\017\002\026\022\021\036\030\017\026\035\034\027\026\016 )0.6(\021\036\030\026\023\017\016 )0.6(\f\004\017\021\026\036\021\f\016 )0.5(\002\036\024\023\026\f\027\024\005 )]TJ 0.138 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC [(\220\235\235\036\022\021\017\r\027\024\005 \007\035\016 \035\036\004\036\ \027\017\016 )0.5(\026\002\f\006\036\f\f\026 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC (\031\f\021\030\026\027\036\027\017\016 )Tj 0.341 Tw T* (\024\f\021\030\024\020\024 \r\024\f\023\026\035\036\027\017\016 \f)Tj /Span<>> BDC ( )Tj EMC (\024\002\013\017\n \023\024\022\026\026\021\036\035\036\n \027\036\031\007\ \026\004 )Tj 0 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (20% \017)Tj /Span<>> BDC ( )Tj EMC (\035\036\021\026\035\034\027\024\f\021\017 0,6% [57].)Tj -0.013 Tw T* (\215\026\006\017\036\027\021\026\n \f)Tj /Span<>> BDC ( )Tj EMC (\027\036\002\024\035\034\001\017\n \(<)Tj /Span<>> BDC ( )Tj EMC (4\2265)Tj /Span<>> BDC ( )Tj EMC (\f\n\) \007\017\r\036\030\021\017\022\031\035\016\030\027\t\n )Tj 0.036 Tw T* (\026\002\f\006\036\f\f\024\n \(\212\202\) \r\024\n\024\032\027\024 \023\ \030\024\r\036\f\021\017 \023\036\030\r\024\027\026\004\026\035\034\027\031\ \033 )Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 0 Tw 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\206)10(\002\036\033 \035\030\032\003\033)30(\n)42(\032)-21(\230\033\241)]TJ 57.136 0 Td (REVIEW)Tj /T1_3 1 Tf 25 0 0 25 506.3146 56.0378 Tm (203)Tj ET endstream endobj 548 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.44 Tw 10 0 0 10 70.8661 724.8299 Tm (\210\f\021\030\t\005 \007\017\r\036\030\021\017\022\031\035\017\021 \024\ \002\024\007\024\004\027\024\005 \022\017\001\022\017 \016\r\035\016\036\ \021\f\016 )Tj 0.176 Tw 0 -1.218 TD (\024\007\027\017\n \017)Tj /Span<>> BDC ( )Tj EMC (\027\026\017\002\024\035\036\036 \030\026\f\023\030\024\f\021\030\026\027\ \036\027\027\t\b \022\035\017\027\017\004\036\f\022\017\b )Tj 0.188 Tw T* (\f\024\f\021\024\016\027\017\005, \f)Tj /Span<>> BDC ( )Tj EMC (\022\024\021\024\030\t\n\017 \f\021\026\035\022\017\r\026\033\021\f\016 \ \b\017\030\031\030\020\017 \r)Tj /Span<>> BDC ( )Tj EMC (\031\f)Tj 0 Tw (-)Tj 0.258 Tw T* (\035\024\r\017\016\b \024\022\026\026\027\017\016 \027\036\024\021\035\024\ \032\027\024\005 \023\024\n\024\013\017. \210\f\021\030\t\005 \007\017)Tj 0 Tw (-)Tj 0.096 Tw T* (\r\036\030\021\017\022\031\035\017\021 \(\210\212\) \030\026\f\023\030\024\ \f\021\030\026\027\036\027 \r)Tj /Span<>> BDC ( )Tj EMC (\026\023\026\007\027\t\b \f\021\030\026\027\026\b, )Tj -0.032 Tw T* (\026)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\032\036 \r)Tj /Span<>> BDC ( )Tj EMC (\217\024\f\f\017\017, \017)Tj /Span<>> BDC ( )Tj EMC (\024\f\024\002\036\027\027\024 \f)Tj /Span<>> BDC ( )Tj EMC (\023\024\030\026\032\036\027\017\036\n \035\036\r\024\005 \023\024)Tj 0 Tw (-)Tj 0.069 Tw 0 -1.218 TD (\035\024\r\017\027\t \024\002\024\007\024\004\027\024\005 \022\017\001\022\ \017 [1], \023\030\017\004\036\n \004\026\013\036 \r\f\021\030\036\004\026\ )Tj 0 Tw (-)Tj 0.009 Tw 0 -1.218 TD (\036\021\f\016 \031)Tj /Span<>> BDC ( )Tj EMC (\035\017\006 \023\024\032\017\035\024\020\024 \r\024\030\026\f\021\026,\ \b\024\021\016 \r)Tj /Span<>> BDC ( )Tj EMC (\023\024\f\035\036\007\027\017\036 \020\024\007\t )Tj 0.057 Tw T* (\024\021\n\036\004\036\027 \f\031\013\036\f\021\r\036\027\027\t\005 \030\ \024\f\021 \026\002\024\035\036\r\026\036\n\024\f\021\017 \r)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\036\036 )Tj 0 Tw T* (\n\024\035\024\007\t\b \r\024\030\026\f\021\027\t\b \020\030\031\023\023\ \026\b [2].)Tj 0.08 Tw T* [(\217\017\f\022 )0.5(\030\026\r\017\021\017\016 )0.5(\210\212 \r\f\021\030\036\004\026\036\021\f\016 )0.5(\031)]TJ /Span<>> BDC ( )Tj EMC 13.79 0 Td [(4% )0.5(\023\026\006\017\036\027\021\024\r \f)]TJ /Span<>> BDC ( )Tj EMC 6.956 0 Td (\007\017)Tj 0 Tw (-)Tj 0.181 Tw -20.745 -1.218 Td (\r\036\030\021\017\022\031\035\016\030\027\024\005 \002\024\035\036\027\ \034\033 \(\212\207\) [3] \017)Tj /Span<>> BDC ( )Tj EMC (\007\026\027\027\t\036 \017\f\f\035\036)Tj 0 Tw (-)Tj 0.189 Tw 0 -1.218 TD (\007\024\r\026\027\017\005 \023\024\f\035\036\007\027\017\b \035\036\021\ \f\r\017\007\036\021\036\035\034\f\021\r\031\033\021 \024)Tj /Span<>> BDC ( )Tj EMC (\021\024\n, \004\021\024 )Tj 0 Tw 0 -1.218 TD (\007\024)Tj /Span<>> BDC ( )Tj EMC (20% \002\024\035\034\027\t\b \f)Tj /Span<>> BDC ( )Tj EMC (\210\212 \n\024\035\024\032\036 50 \035\036\021 [4,5].)Tj 0.071 Tw 0 -1.218 TD (\232\026\f\021\024\021\026 \210\212 \030\026\f\021\036\021 \f)Tj /Span<>> BDC ( )Tj EMC (\021\036\004\036\027\017\036\n \r\030\036\n\036\027\017. \230\026\022, \031\ \030\024\r\036\027\034 )Tj 0.065 Tw T* [(\027\036\024\021\035\024\032\027\t\b )0.6(\020\024\f\023\017\021\026\035\017\026\006\017\005 )0.6(\r)]TJ /Span<>> BDC ( )Tj EMC 13.024 0 Td [(\202\027\020\035\017\017 )0.6(\026)]TJ /Span<>> BDC ( )Tj EMC 4.431 0 Td [(10 )0.5(\035\036\021 )0.5(\031\r\036)]TJ 0 Tw (-)Tj 0.16 Tw -17.455 -1.218 Td (\035\017\004\017\035\f\016 \027\026)Tj /Span<>> BDC ( )Tj EMC (16% \031)Tj /Span<>> BDC ( )Tj EMC (\n\031\032\004\017\027 \017)Tj /Span<>> BDC ( )Tj EMC (\027\026 12% \031)Tj /Span<>> BDC ( )Tj EMC (\032\036\027\013\017\027 [6], )Tj 0.1 Tw T* (\026)Tj /Span<>> BDC ( )Tj EMC 0.796 0 Td (\r)Tj /Span<>> BDC ( )Tj EMC 0.807 0 Td [(\224\221\202 )0.5(\026)]TJ /Span<>> BDC ( )Tj EMC 3.392 0 Td [(7 )0.5(\035\036\021 \004\017\f\035\024 )0.5(\024\002\030\026\013\036\027\017\005 )0.6(\r\t\030\024\f\035\024 \027\026)]TJ /Span<>> BDC ( )Tj EMC 15.357 0 Td (26% )Tj 0.03 Tw -20.351 -1.218 Td ([7]. \216\024\021\016 \210\212 \b\026\030\026\022\021\036\030\017\031\036\ \021\f\016 \027\017\022\017\n \031\030\024\r\027\036\n \f\n\036\030\021\ )Tj 0 Tw (-)Tj 0.016 Tw T* [(\027\024\f\021\017, )0.5(\024\027 \n\024\032\036\021 \023\030\017\r\036\f\021\017 )0.5(\022)]TJ /Span<>> BDC ( )Tj EMC [(\f\036\030\034\036\027\t\n )0.5(\024\f\035\024\032\027\036\027\017\016\n, )]TJ -0.031 Tw T* (\021\026\022\017\n \022\026\022 \026\002\f\006\036\f\f \n\026\035\024\020\ \024 \021\026\026, \023\036\030\235\024\030\026\006\017\016 \022\017\001\ \036\004\027\017)Tj 0 Tw (-)Tj -0.002 Tw T* (\022\026, \022\017\001\036\004\027\t\005 \f\r\017\013, \022\017\001\036\004\ \027\026\016 \027\036\023\030\024\b\024\007\017\n\024\f\021\034, \023\036\ \030\017)Tj 0 Tw (-)Tj T* (\021\024\027\017\021, \f\036\023\f\017\f [8].)Tj -0.043 Tw T* (\203\036\f\n\024\021\030\016 \027\026)Tj /Span<>> BDC ( )Tj EMC (\023\024\035\027\031\033 \030\036\n\017\f\f\017\033, \007\024\f\021\026\021\ \024\004\027\024 \004\026\f\021\024 \r\024)Tj 0 Tw (-)Tj T* (\027\017\022\026\033\021 \030\036\006\017\007\017\r\t \023\024\f\035\036\ \024\f\021\030\024\020\024 \220\023\017\024\007\026 \210\212 [9,10].)Tj 0.356 Tw T* (\232\026\f\021\034 \002\024\035\034\027\t\b \023\024\007\r\036\030\020\026\ \036\021\f\016 \024\023\036\030\026\021\017\r\027\024\n\t\n \r\n\036)Tj 0 Tw (-)Tj 0.104 Tw T* [(\001\026\021\036\035\034\f\021\r\026\n \r\r\017\007\031 \002\036\031\f\023\ \036\001\027\024\f\021\017 )0.5(\035\036\004\036\027\017\016. \224\035\036\007\031\036\021 )]TJ 0.306 Tw T* (\024\021\n\036\021\017\021\034, \004\021\024 \b\026\030\026\022\021\036\030\ \017\f\021\017\022\017 \023\030\026\r\024\f\021\024\030\024\027\027\036\020\ \024 \210\212 )Tj 0.16 Tw T* (\024\021\035\017\004\026\033\021\f\016 \024\021 \035\036\r\024\f\021\024\ \030\024\027\027\036\020\024 \210\212, \r\022\035\033\004\026\016 \004\026\ \f\021\024\021\031 )Tj 0.005 Tw T* [(\030\036\006\017\007\017\r\024\r )0.5([11]. )0.6(\224\017\020\n\024\r\017\007\027\026\016 )0.5(\022\017\001\022\026 )0.6(\016\r\035\016\036\021\f\016 )0.6(\027\026\017\002\024)]TJ 0 Tw (-)Tj 0.078 Tw T* [(\035\036\036 )0.5(\004\026\f\021\024 )0.5(\023\024\030\026\032\026\036\n\t\n )0.5(\f\036\020\n\036\027\021\024\n )0.5(\024\002\024\007\024\004\027\024\005 )0.5(\022\017\001\022\017, )]TJ 0.102 Tw T* (\026)Tj /Span<>> BDC ( )Tj EMC (\024\f\021\030\t\005 \023\030\026\r\024\f\021\024\030\024\027\027\017\005\ \007\017\r\036\030\021\017\022\031\035\017\021 \(\210\215\212\) \004\026\ \013\036 )Tj 0 Tw T* (\r\f\021\030\036\004\026\036\021\f\016 \r)Tj /Span<>> BDC ( )Tj EMC (\f\021\030\026\027\026\b \202\017\017.)Tj 0.361 Tw T* (\215\024\f\035\036\007\027\017\036 \030\036\022\024\n\036\027\007\026\006\ \017\017 \023\024)Tj /Span<>> BDC ( )Tj EMC (\210\212 \030\026\030\026\002\026\021\t\r\026\035\017\f\034 )Tj 0.085 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\f\024\024\021\r\036\021\f\021\r\017\017 \f)Tj /Span<>> BDC ( )Tj EMC (\n\036\021\024\007\024\035\024\020\017\036\005 GRADE [12,13], \024\f\027\ \024)Tj 0 Tw (-)Tj 0.223 Tw T* (\r\026\027\027\024\005 \027\026)Tj /Span<>> BDC ( )Tj EMC (\007\024\022\026\026\021\036\035\034\f\021\r\026\b, \f\017\f\021\036\n\026\ \021\017\004\036\f\022\017 \024\006\036\027\017)Tj 0 Tw (-)Tj 0.002 Tw T* (\r\026\033\013\017\b \017\n\036\033\013\031\033\f\016 \035\017\021\036\030\ \026\021\031\030\031, \017)Tj /Span<>> BDC ( )Tj EMC (\024\027\017 \235\024\022\031\f\017\030\031\033\021\f\016 )Tj 0.143 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC (\031\030\024\r\027\036 \007\024\022\026\026\021\036\035\034\f\021\r \027\ \026)Tj /Span<>> BDC ( )Tj EMC (\024\f\027\024\r\036 \021\017\023\024\r \r\022\035\033\004\036\027)Tj 0 Tw (-)Tj T* (\027\t\b \017\f\f\035\036\007\024\r\026\027\017\005.)Tj 0.524 Tw T* (\025\024\n\023\034\033\021\036\030\027\026\016 \021\024\n\024\020\030\026\ \235\017\016 \(\025\230\) \f\021\026\035\026 \024\f\027\024\r\027\t\n )Tj 0.621 Tw T* [(\007\017\026\020\027\024\f\021\017\004\036\f\022\017\n )0.6(\017\027\f\021\030\031\n\036\027\021\024\n )0.6(\023\030\017)]TJ /Span<>> BDC ( )Tj EMC 16.99 0 Td (\007\017\026\020\027\024\f\021\017\022\036 )Tj 0.016 Tw -16.99 -1.218 Td (\017)Tj /Span<>> BDC ( )Tj EMC 0.767 0 Td [(\f\021\026\007\017\030\024\r\026\027\017\017 \210\212, )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC [(\027\026 )0.5(\036\036 )0.5(\024\f\027\024\r\036 \002\t\035\024 )0.5(\023\030\036\007\035\024\032\036\027\024 )]TJ -0.017 Tw -0.767 -1.218 Td [(\027\036\f\022\024\035\034\022\024 \n\024\007\017\235\017\022\026\006\017\ \005 \022\035\026\f\f\017\235\017\022\026\006\017\017 Hinche)-11(y)]TJ /Span<>> BDC ( )Tj EMC (E.J. )Tj 0 Tw T* (\(1978\) [4,14\22616].)Tj 0.258 Tw T* (\224\030\036\007\017 \220\021\017\b \n\024\007\017\235\017\022\026\006\017\ \005 \027\026\017\002\024\035\034\001\031\033 \017\r\036\f\021\027\024\f\ \021\034 )Tj 0.286 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC [(\030\026\f\023\030\024\f\021\030\026\027\036\027\017\036 \023\024\035\031\ \004\017\035\026 )0.5(\022\035\026\f\f\017\235\017\022\026\006\017\016 WSES )]TJ 0.06 Tw T* ([16], \024\f\027\024\r\026\027\027\026\016 \021\026\022\032\036 \027\026\ )Tj /Span<>> BDC ( )Tj EMC (\030\036\031\035\034\021\026\021\026\b \025\230, \017)Tj /Span<>> BDC ( )Tj EMC (\022\024\021\024\030\026\016 )Tj 0.159 Tw T* (\n\024\032\036\021 \f\035\031\032\017\021\034 \030\031\022\024\r\024\007\ \f\021\r\024\n \007\035\016 \r\030\026\004\036\005 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\035\036\004\036)Tj 0 Tw (-)Tj -0.044 Tw T* (\027\017\017 \210\212. \212\026\027\027\026\016 \022\035\026\f\f\017\235\ \017\022\026\006\017\016 \007\036\035\017\021 \210\212 \027\026)Tj /Span<>> BDC ( )Tj EMC (2 \020\030\031\023\023\t: )Tj 0 Tw T* (\027\036\024\f\035\024\032\027\036\027\027\t\005 \(\210\203\212\) \017)Tj /Span<>> BDC ( )Tj EMC (\024\f\035\024\032\027\036\027\027\t\005 \(\210\210\212\).)Tj 0.58 Tw T* [(\210\f\035\024\032\027\036\027\027\t\005 )0.5(\024\f\021\030\t\005 \007\017\r\036\030\021\017\022\031\035\017\021 )0.5(\007\036\035\017\021\f\016 )0.5(\027\026: )]TJ 0.036 Tw T* (1\202)Tj /Span<>> BDC ( )Tj EMC (\227 \023\036\030\017\022\024\035\017\004\036\f\022\017\036 \023\031\t\030\ \034\022\017 \020\026\026 \017\035\017 \027\036\002\024\035\034\001\024\ \036 )Tj 0.215 Tw T* (\022\024\035\017\004\036\f\021\r\024 \024\022\024\035\024\022\017\001\036\ \004\027\024\005 \032\017\007\022\024\f\021\017 \002\036 \026\002\f\006\ \036\f\f\026 )Tj 0.107 Tw T* (\(\r)Tj /Span<>> BDC ( )Tj EMC (\023\030\036\007\036\035\026\b 5 \f\n \024\021 \r\024\f\023\026\035\036\027\ \027\024\020\024 \f\036\020\n\036\027\021\026 \022\017\001\022\017\); )Tj -0.045 Tw 23.244 64.543 Td (1\200)Tj /Span<>> BDC ( )Tj EMC (\227 \026\002\f\006\036\f\f)Tj /Span<>> BDC ( )Tj EMC (\245)Tj /Span<>> BDC ( )Tj EMC [(4 )0.5(\f\n; 2\202)]TJ /Span<>> BDC ( )Tj EMC (\227 \026\002\f\006\036\f\f)Tj /Span<>> BDC ( )Tj EMC (>)Tj /Span<>> BDC ( )Tj EMC (4 \f\n; 2\200)Tj /Span<>> BDC ( )Tj EMC 18.733 0 Td (\227 \024\021\007\026)Tj 0 Tw (-)Tj -0.007 Tw -18.733 -1.218 Td (\035\036\027\027\t\005 \020\026 \(>)Tj /Span<>> BDC ( )Tj EMC (5 \f\n \024\021 \r\024\f\023\026\035\036\027\027\024\020\024 \f\036\020\n\ \036\027\021\026 \022\017\001\022\017\); )Tj 0.137 Tw T* (3)Tj /Span<>> BDC ( )Tj EMC (\227 \007\017\235\235\031\027\026\016 \032\017\007\022\024\f\021\034 \002\ \036 \024\021\007\026\035\036\027\027\024\020\024 \f\r\024\002\024\007)Tj 0 Tw (-)Tj 0.155 Tw T* (\027\024\020\024 \020\026\026; 4)Tj /Span<>> BDC ( )Tj EMC (\227 \007\017\235\235\031\027\026\016 \032\017\007\022\024\f\021\034 \f\ )Tj /Span<>> BDC ( )Tj EMC (\024\021\007\026\035\036\027\027\t\n )Tj 0 Tw T* (\f\r\024\002\024\007\027\t\n \020\026\024\n.)Tj 0.349 Tw T* (\200 \217\024\f\f\017\005\f\022\024\005 \205\036\007\036\030\026\006\017\ \017 \017\f\023\024\035\034\031\036\021\f\016 \022\035\026\f\f\017\235\017\ )Tj 0 Tw (-)Tj 0.247 Tw 0 -1.218 TD [(\022\026\006\017\016 \007\017\r\036\030\021\017\022\031\035\016\030\027\024\ \005 )0.5(\002\024\035\036\027\017 \024\002\024\007\024\004\027\024\005 \022\017\001\ \022\017 )]TJ 0.439 Tw 0 -1.218 TD (\r)Tj /Span<>> BDC ( )Tj EMC (\f\024\024\021\r\036\021\f\021\r\017\017 \f)Tj /Span<>> BDC ( )Tj EMC (\025\035\017\027\017\004\036\f\022\017\n\017 \030\036\022\024\n\036\027\007\ \026\006\017\016\n\017 )Tj 0.023 Tw T* [([17], )0.5(\030\026\030\026\002\024\021\026\027\027\026\016 )0.6(\r)]TJ /Span<>> BDC ( )Tj EMC 9.328 0 Td [(\205\206\207\211 )0.5(\253\203\204\236\037 )0.5(\022\024\035\024\023\030\024\022\021\024\035\024\020\017\017 )]TJ 0 Tw -9.328 -1.218 Td (\017\n\036\027\017 \202.\203. \217\t\032\017\b\273 \204\017\027\007\030\ \026\r\026 \217\024\f\f\017\017.)Tj 0.016 Tc 0.105 Tw T* (\210\002\013\026\016 \004\026\f\021\024\021\026 \030\036\006\017\007\017\ \r\024\r \023\030\017)Tj /Span<>> BDC ( )Tj EMC [(\023\030\026\r\024\f\021\024\030\024\027\027\036\n \210\212)16( )]TJ 0.113 Tw T* (\f\024\f\021\026\r\017\035\026 10% \(95% \212\236 8\22613%\), \023\030\017\ )Tj /Span<>> BDC ( )Tj EMC (\210\203\212)Tj /Span<>> BDC ( )Tj EMC [(\227 99%)16( )]TJ 0.117 Tw 0 -1.218 TD (\(95% \212\236 6\22613%\) [18], \023\030\017\004\036\n \r\024\030\026\f\ \021 \()Tj /T1_1 1 Tf 0 Tc 0 Tw (\033)Tj /T1_0 1 Tf 0.016 Tc 0.117 Tw /Span<>> BDC 18.228 0 Td ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC [(0,184\))16( )]TJ 0.148 Tw -18.228 -1.218 Td (\017)Tj /Span<>> BDC ( )Tj EMC (\023\024\035 \()Tj /T1_1 1 Tf 0 Tc 0 Tw (\033)Tj /T1_0 1 Tf 0.016 Tc 0.148 Tw /Span<>> BDC 3.733 0 Td ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,932\) \027\036 \002\t\035\017 \f\r\016\026\027\t \f)Tj /Span<>> BDC ( )Tj EMC (\030\017\f\022\024\n \030\026)Tj 0 Tc 0 Tw (-)Tj 0.016 Tc 0.101 Tw -3.733 -1.218 Td [(\r\017\021\017\016 \030\036\006\017\007\017\r\026. \204\027\024\032\036\f\ \021\r\036\027\027\t\036 \007\017\r\036\030\021\017\022\031\035\t \r\027\ \036)16( )]TJ 0.112 Tw 0 -1.218 TD [(\023\030\026\r\024\005 \023\024\035\024\r\017\027\t \024\002\024\007\024\ \004\027\024\005 \022\017\001\022\017 \002\t\035\017 \f\r\016\026\027\t\ )16( )]TJ 0.235 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC [(\002\024\035\036\036 \r\t\f\024\022\017\n \030\017\f\022\024\n \030\036\006\ \017\007\017\r\026 [19]. \232\026\f\021\024\021\026)16( )]TJ 0.269 Tw T* (\027\036\031\007\026\004 \022\024\027\f\036\030\r\026\021\017\r\027\024\020\ \024 \035\036\004\036\027\017\016, \r)Tj /Span<>> BDC ( )Tj EMC (\f\030\036\007\027\036\n, \f\024)Tj 0 Tc 0 Tw (-)Tj 0.016 Tc 0.205 Tw T* (\f\021\026\r\035\016\036\021 5% \(95% \212\236 2\22610%\). \200\024\030\ \026\f\021)Tj /Span<>> BDC ( )Tj EMC (>)Tj /Span<>> BDC ( )Tj EMC [(50 \035\036\021,)16( )]TJ 0.393 Tw T* [(\023\024\r\021\024\030\016\033\013\017\036\f\016 )0.5(\220\023\017\024\007\t )0.5(\024\f\021\030\024\020\024 )0.5(\007\017\r\036\030\021\017\022\031\035\017\021\026,)16( )]TJ 0.2 Tw T* [(\023\024\r\t\001\036\027\027\t\005 )0.5(\031\030\024\r\036\027\034 )0.5(\224\217\207 )0.5(\002\t\035\017 )0.6(\235\026\022\021\024\030\026\n\017 )0.5(\030\017\f\022\026)16( )]TJ 0.105 Tw T* [(\002\036\031\f\023\036\001\027\024\f\021\017 \022\024\027\f\036\030\r\026\ \021\017\r\027\024\020\024 \035\036\004\036\027\017\016 [20], \022\026\022\ )16( )]TJ 0.227 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\n\027\024\032\036\f\021\r\036\027\027\t\036 \007\017\r\036\030\021\017\022\ \031\035\t \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\023\030\026\r\024\f\021\024\030\024\027)Tj 0 Tc 0 Tw (-)Tj 0.016 Tc T* (\027\036\n \210\212 [21].)Tj 0 Tc 0.087 Tw T* [(\215\030\017 \035\036\r\024\f\021\024\030\024\027\027\036\n \007\017\r\036\ \030\021\017\022\031\035\017\021\036, )0.5(\f\030\036\007\027\017\005 )0.5(\r\024\030\026\f\021 )]TJ 0.058 Tw T* (\023\026\006\017\036\027\021\024\r \f\024\f\021\026\r\017\035 61,4 \020\024\ \007\026, \r)Tj /Span<>> BDC ( )Tj EMC (\021\024\n \004\017\f\035\036 45% \n\031\032)Tj 0 Tw (-)Tj 0.028 Tw T* (\004\017\027, \004\026\f\021\024\021\026 \030\036\006\017\007\017\r\024\r\ \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\023\024\030\026\032\036\027\017\017 \f\017\020\n\024\r\017\007\027\024\005\ )Tj 0.132 Tw T* [(\022\017\001\022\017 )0.5(\f\024\f\021\026\r\017\035\026 )0.6(47%, )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 10.695 0 Td [(17% )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 3.433 0 Td [(\027\017\b )0.5(\023\024\021\030\036\002\024\r\026\035\024\f\034 )]TJ 0.094 Tw -14.128 -1.218 Td [(\b\017\030\031\030\020\017\004\036\f\022\024\036 )0.5(\035\036\004\036\027\017\036 )0.5([22]. \215\024)]TJ /Span<>> BDC ( )Tj EMC [(\007\030\031\020\017\n \007\026\027\027\t\n, )0.5(\004\026)]TJ 0 Tw (-)Tj 0.017 Tw T* (\f\021\024\021\026 \030\036\006\017\007\017\r\024\r \f\024\f\021\026\r\017\ \035\026 43% [23], \b\024\021\016 \r)Tj /Span<>> BDC ( )Tj EMC (\027\036\f\022\024\035\034)Tj 0 Tw (-)Tj -0.025 Tw T* (\022\017\b \017\f\f\035\036\007\024\r\026\027\017\016\b \f\024\024\002\013\ \026\035\024\f\034 \024)Tj /Span<>> BDC ( )Tj EMC (\004\026\f\021\024\021\036 3\2266% \023\024\f\035\036 )Tj 0 Tw T* (\022\024\027\f\036\030\r\026\021\017\r\027\024\020\024 \035\036\004\036\027\ \017\016 [24\22626].)Tj 0.318 Tw T* (\210\002\013\026\016 \004\026\f\021\024\021\026 \030\036\006\017\007\017\ \r\024\r \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\210\212 \f\024\f\021\026\r\017\035\026 20% )Tj 0.003 Tw T* (\(95% \212\236 16\22624%\), \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\210\203\212)Tj /Span<>> BDC ( )Tj EMC (\227 15% \(95% \212\236 8\22627%\), )Tj -0.031 Tw T* (\027\036 \024\021\n\036\004\036\027\024 \030\026\035\017\004\017\036 \r\ )Tj /Span<>> BDC ( )Tj EMC (\004\026\f\021\024\021\036 \030\036\006\017\007\017\r\024\r \(20% \023\030\ \024)Tj 0 Tw (-)Tj 0.017 Tw T* (\021\017\r 19%, )Tj /T1_1 1 Tf 0 Tw (\033)Tj /T1_0 1 Tf 0.017 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,334\) \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r, \023\024\035\031\004\026\r\001\017\b\ \017)Tj /Span<>> BDC ( )Tj EMC (\027\036 \023\024)Tj 0 Tw (-)Tj T* (\035\031\004\026\r\001\017\b \026\027\021\017\002\017\024\021\017\022\017\ [18].)Tj 0.108 Tw T* (\203\026\017\002\024\035\036\036 \004\026\f\021\024 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\210\212 \024\021\n\036\004\026\036\021\f\016 \024\f\021\030\026\016 \002\ \024\035\034 \017\035\017 )Tj 0.355 Tw T* [(\002\024\035\036\027\036\027\027\024\f\021\034 )0.6(\r)]TJ /Span<>> BDC ( )Tj EMC 7.781 0 Td [(\035\036\r\024\n )0.5(\027\017\032\027\036\n )0.5(\022\r\026\007\030\026\027\021\036, )0.5(\023\024\r\t)]TJ 0 Tw (-)Tj 0.212 Tw -7.781 -1.218 Td (\001\036\027\017\036 \224-\030\036\026\022\021\017\r\027\024\020\024 \002\ \036\035\022\026 \(\224\217\207\), \022\024\035\017\004\036\f\021\r\026 \ \035\036\005)Tj 0 Tw (-)Tj 0.207 Tw T* [(\022\024\006\017\021\024\r, )0.5(\b\024\021\016 )0.6(\022\035\017\027\017\004\036\f\022\017 )0.5(\007\017\026\020\027\024\f\021\017\022\026 )0.5(\210\212 )0.5(\027\036\021\024\004\027\026, )]TJ 0.179 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\023\024\035\024\032\017\021\036\035\034\027\026\016 \017)Tj /Span<>> BDC ( )Tj EMC (\024\021\030\017\006\026\021\036\035\034\027\026\016 \023\030\024\020\027\ \024\f\021\017\004\036\f\022\026\016 )Tj 0.228 Tw T* [(\006\036\027\027\024\f\021\034 \022\035\017\027\017\004\036\f\022\024\020\ \024 )0.5(\007\017\026\020\027\024\026 \f\024\f\021\026\r\035\016\036\021\f\016 )0.5(0,65 )]TJ 0.397 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (0,98, \f\024\024\021\r\036\021\f\021\r\036\027\027\024 [27], \026)Tj /Span<>> BDC ( )Tj EMC (\023\030\017 \007\024\023\024\035\027\017\021\036\035\034)Tj 0 Tw (-)Tj 0.274 Tw T* (\027\024\005 \r\017\031\026\035\017\026\006\017\017)Tj /Span<>> BDC ( )Tj EMC (\227 0,95 \017)Tj /Span<>> BDC ( )Tj EMC (0,99, \f\024\024\021\r\036\021\f\021\r\036\027\027\024. )Tj 0.058 Tw T* (\212\024\023\024\035\027\017\021\036\035\034\027\t\036 \030\026\007\017\024\ \035\024\020\017\004\036\f\022\017\036 \017\f\f\035\036\007\024\r\026\027\ \017\016 \023\024)Tj 0 Tw (-)Tj 0.009 Tw T* (\r\t\f\017\035\017 \021\024\004\027\024\f\021\034 \007\017\026\020\027\024\ \f\021\017\022\017 \031)Tj /Span<>> BDC ( )Tj EMC (37%, \b\024\021\016 \021\026\022\021\017\022\031 \035\036)Tj 0 Tw (-)Tj T* (\004\036\027\017\016 \017\n\036\027\017\035\017 \021\024\035\034\022\024\ \031)Tj /Span<>> BDC ( )Tj EMC (7% \023\026\006\017\036\027\021\024\r.)Tj 0.247 Tw T* (\224\217\207 \f\004\017\021\026\036\021\f\016 \023\024\035\036\027\t\n \ \002\017\024\n\026\030\022\036\030\024\n \r\024\f\023\026\035\036\027\017\ \016, )Tj 0.212 Tw T* (\n\024\032\036\021 \023\030\017\n\036\027\016\021\034\f\016 \007\035\016\ \023\030\024\020\027\024\017\030\024\r\026\027\017\016 \022\035\017\027\ \017\004\036)Tj 0 Tw (-)Tj 0.222 Tw T* (\f\022\024\005 \021\016\032\036\f\021\017 \210\212 [28,29]. \215\024\030\ \024\020\024\r\024\036 \027\026\004\036\027\017\036 \224\217\207 )Tj 0.312 Tw T* (170 \n\020/\035 \007\024\f\021\024\r\036\030\027\024 \024\021\035\017\004\ \026\035\024 \021\016\032\036\035\031\033 \026\021\026\022\031 \210\212 \ )Tj 0.232 Tw T* (\024\021 \035\036\020\022\024\005 \(\004\031\r\f\021\r\017\021\036\035\034\ \027\024\f\021\034 87,5%, \f\023\036\006\017\235\017\004\027\024\f\021\034\ )Tj 0 Tw T* (91,1%, \023\035\024\013\026\007\034 \023\024\007 \022\030\017\r\024\005 \ 0,942, )Tj /T1_1 1 Tf (\033)Tj /T1_0 1 Tf /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (0,00001\) [28].)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\206)10(\002\036\033 \035\030\032\003\033)30(\n)42(\032)-21(\230\033\241)]TJ 57.136 0 Td (REVIEW)Tj -57.136 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 2)69(4, \023\0224, 202)23(5)]TJ 43.013 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 2)69(4, \023\0224, 202)23(5)]TJ /T1_3 1 Tf 25 0 0 25 21.6028 56.0378 Tm (202)Tj ET endstream endobj 545 0 obj [552 0 R] endobj 546 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\006\025\222\201\025\b\220 \211\021\001\202\215\025\b)-10(\026\021\017\021 \021\022\t\016\f\016\215\021\004 \025\b)-9.9(\026\201\025\202)10(\025 \211\021\r\016\201\026\021\017\200\t\021\026)11(\001 )]TJ 0 -1 TD [(\025\235\025\211\025\f\215\025\207 \017\021\020\017\021 \(\025\235\213\025\ \201 \t\021\026)11(\016\201\001\026)-20(\200\201\220\))]TJ 43.987 1 Td [(Issues of\022diagnosis and tr)31.1(eatment of\022acute )]TJ 3.463 -1 Td [(div)12(er)-20(ticulitis of\022th)11(e colon \(r)31(e)11(vie)11(w\))]TJ ET 0 0 0 1 K 1 j 1 J [0 2.997]0 d /GS1 gs q 1 0 0 1 46.0167 477.141 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 43.0197 477.141 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q [0 2.997]0 d q 1 0 0 1 46.0167 439.9332 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 43.0197 439.9332 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q [0 2.997]0 d q 1 0 0 1 46.0167 215.179 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 43.0197 215.179 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q [0 2.997]0 d q 1 0 0 1 46.0167 187.5712 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 43.0197 187.5712 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q 0 j 0 J q 1 0 0 1 42.5197 133.502 cm 0 0 m 453.543 0 l S Q BT 0 0 0 1 k /T1_1 1 Tf 10 0 0 10 42.5197 724.8299 Tm (https://doi.org/10.33878/2073-7556-2025-24-4-201-208)Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 0.023 Tw 19 0 0 19 49.2322 695.3259 Tm [(\006\025\222\201\025\b\220 \211\021\001\202\215\025\b)-10(\026\021\017\021 \021\022)-23.2(\t\016\f\016\215\021\004 \025\b)-10(\026\201\025\202)10(\025 \211\021\r\016\201\026\021\017\200\t\021\026)11(\001 )]TJ 3.576 -1.105 Td [(\025\235\025\211\025\f\215\025\207 \017\021\020\017\021 \(\025\235\213\025\ \201 \t\021\026)11(\016\201\001\026)-19.9(\200\201\220\))]TJ 0 0 0 1 k /GS1 gs 14 0 0 14 42.5197 649.822 Tm [(\032)30(\021\024\016\201\235\200\t\001\026)11.1(\025\r\022)-23.3(\255.\006., \031)55(\001\223\001\201\025\r\001\022)-23.2(\n)-31(.\033)124(., \032)30(\021\024\016\201\235\200\t\001\026)11.1(\025\r\022)-23.3(\006.\007.)]TJ 10 0 0 10 42.5197 632.1527 Tm [(\203\031\206)21(\036)20(\230 \006\036 \253\206\001\020\017\021\201\b\017\021\207 \202)10.1(\025\b\200\211\001\201\b)-10(\026\r\016\215\215\220\207 \024\016\211\021\212\021\215\b\017\021\207 \200\ \215\021\r\016\201\b\021\026)11.1(\016\026\273 \007\021\215\213\211\201\001\r\001 \033\025\b\b\021\021 \(\200\ \t.\022)-23.2(\035\016\215\021\215\001, \211.\022)-23.3(3, )]TJ 0 -1.2 TD [(\202)62(.\022)-23.3(\230)52(\223\001, 450008, \033\025\b\b\021\004\))]TJ /T1_1 1 Tf 0.114 Tw 9 0 0 9 90.7087 601.6488 Tm [( \034\025\031\034\033\016 )0.5(\027\022\035\016\033\037\035\023\033\032 )0.5(\034\024\036\016\235\016\020\032 )0.5(\024\034\036\033\016\006\016\020\020\032\016 )0.5(\f\034\b\002\034\b\032 \021)]TJ /Span<>> BDC ( )Tj EMC (\b\022\037\013\020\034\024\035\022\021\016 \022)Tj /Span<>> BDC ( )Tj EMC (\036\032\025\034\033\023 \006\016\035\034\b\037 \027\016\005\016\020\022\ \030 \034\024\035\033\034\013\034 )Tj 0.002 Tc 0.35 Tw 0 -1.111 TD [(\b\022\036\016\033\035\022\021\023\027\022\035\037 )0.5(\034\025\034\b\034\005\020\034\004 )0.5(\021\022\001\021\022. )0.6(\213\037\024\024\006\034\035\033\016\020\032 )0.6(\031\020\037\005\022\006\034\024\035\003, )0.5(\220\017\017\016\021\035\022\036\020\034\024\035\003 )0.6(\021\027\022\020\022\021\034-\027\037\025\034\033\037\035\034\033\020\032\ \002)2( )]TJ 0 Tc 0.157 Tw T* (\022)Tj /Span<>> BDC ( )Tj EMC 0.889 0 Td [(\036\022\031\023\037\027\022\031\037\007\022\034\020\020\032\002 )0.5(\006\016\035\034\b\034\036 )0.6(\022\024\024\027\016\b\034\036\037\020\022\030. )0.6(\215\027\003\035\033\037\031\036\023\021\034\036\034\016 )0.6(\022\024\024\027\016\b\034\036\037\020\022\016 )0.5(\022)]TJ /Span<>> BDC ( )Tj EMC 32.347 0 Td [(\021\034\006\f\003\026\035\016\033\020\037\030 )0.5(\035\034\006\034\013\033\037\017\022\030 )]TJ 0.097 Tw -33.235 -1.111 Td (\036)Tj /Span<>> BDC ( )Tj EMC (\020\037\024\035\034\030\235\016\016 \036\033\016\006\030 \030\036\027\030\ \026\035\024\030 \020\037\022\025\034\027\016\016 \035\034\005\020\032\006\ \022 \006\016\035\034\b\037\006\022 \b\022\037\013\020\034\024\035\022\021\ \022 \034\024\035\033\034\013\034 \b\022\036\016\033\035\022\021\023\027\ \022\035\037, \024)Tj /Span<>> BDC ( )Tj EMC (\005\023\036)Tj 0 Tw (-)Tj 0.239 Tw T* (\024\035\036\022\035\016\027\003\020\034\024\035\003\026 85\22697%, \024\ \f\016\007\022\017\022\005\020\034\024\035\003\026 90\22699%. \240\024\034\ \025\034\016 \036\020\022\006\037\020\022\016 \023\b\016\027\016\020\034\ \002\022\033\023\033\013\022\005\016\024\021\034\004 \035\037\021\035\022\ \021\016 )Tj 0.074 Tw 0 -1.111 TD (\f\033\022)Tj /Span<>> BDC ( )Tj EMC (\034\024\027\034\201\020\016\020\020\034\006 \b\022\036\016\033\035\022\021\ \023\027\022\035\016, \033\034\027\022 \022)Tj /Span<>> BDC ( )Tj EMC (\006\016\024\035\023 \005\033\016\024\021\034\201\020\032\002 \036\006\016\ \001\037\035\016\027\003\024\035\036, \033\037\031\027\022\005\020\032\006\ \036\037\033\022\037\020\035\037\006 \033\016\031\016\021)Tj 0 Tw (-)Tj 0.023 Tw 0 -1.111 TD (\007\022\022 \034\025\034\b\034\005\020\034\004 \021\022\001\021\022, \036\ )Tj /Span<>> BDC ( )Tj EMC (\035\034\006 \005\022\024\027\016 \027\037\f\037\033\034\024\021\034\f\022\ \005\016\024\021\022\006 \b\034\024\035\023\f\034\006.)Tj /T1_2 1 Tf 0.01 Tc 0.207 Tw 8 0 0 8 42.5596 526.3795 Tm [(\037\033\016\r\030\025\f\030)5( \026\033\036\025\021:)]TJ /T1_1 1 Tf 0 Tc 0.212 Tw 8.682 0 Td ( \034\024\035\033\032\004 \b\022\036\016\033\035\022\021\023\027\022\035\ , \034\024\027\034\201\020\016\020\020\032\004 \b\022\036\016\033\035\022\ \021\023\027\022\035, \b\022\037\013\020\034\024\035\022\021\037, \021\034\ \020\024\016\033\036\037\035\022\036\020\034\016 \027\016\005\016\020\022\ \016, \006\022\020\022\022\020\036\037\031\022\036\020\032\016 )Tj 0.023 Tw -8.687 -1.2 Td (\006\016\035\034\b\032, \002\022\033\023\033\013\022\005\016\024\021\022\ \016 \036\006\016\001\037\035\016\027\003\024\035\036\037)Tj /T1_2 1 Tf 0.01 Tc 0.018 Tw 0.005 -1.909 Td [(\037\036\035\034\033\032\037\031)5( \032\035\031\030\027\030\026\036\025:)]TJ /T1_1 1 Tf 0 Tc 0.023 Tw 10.401 0 Td ( \037\036\035\034\033\032 \031\037\030\036\027\030\026\035 \034\025 \034\ \035\024\023\035\024\035\036\022\022 \021\034\020\017\027\022\021\035\037\ \022\020\035\016\033\016\024\034\036)Tj /T1_2 1 Tf 0.01 Tc -0.01 Tw -10.401 -1.909 Td (\034\032\035\021\035\026\032\027\036\025\021\035\032\030:)Tj /T1_1 1 Tf 0 Tc 0.023 Tw 8.655 0 Td ( \022\024\035\034\005\020\022\021\022 \017\022\020\037\020\024\022\033\034\ \036\037\020\022\030 \034\035\024\023\035\024\035\036\023\026\035)Tj /T1_2 1 Tf 0.03 Tc -0.04 Tw -8.655 -2.617 Td [(\024)0.5(\033)0.5(\023)5.5( )0.5(\022)0.5(\032)0.5(\031)0.5(\032)0.5(\027)0.6(\036)0.5(\025)0.5(\021)0.5(\035)0.5(\032)0.5(\023)0.5(:)]TJ /T1_3 1 Tf 0.02 Tc -0.035 Tw 9.072 0 Td [( )0.5(\230)0.5(\017)0.5(\n)0.5(\036)0.5(\030)0.5(\002)0.5(\031)0.6(\035)0.5(\026)0.5(\021)0.5(\024)0.5(\r)]TJ /Span<>> BDC 6.213 0 Td ( )Tj EMC 0.218 0 Td [(\221)0.5(.)0.5(\200)0.5(.)0.6(,)0.5( \206)0.6(\026)0.5(\235)0.5(\026)0.5(\030)0.5(\024)0.5(\r)0.5(\026)]TJ /Span<>> BDC 6.576 0 Td ( )Tj EMC 0.218 0 Td [(\202)0.5(.)0.5(\217)0.6(.)0.5(,)0.5( )0.5(\230)0.5(\017)0.5(\n)0.5(\036)0.5(\030)0.5(\002)0.5(\031)0.5(\035)0.6(\026)0.5(\021)0.5(\024)0.5(\r)]TJ /Span<>> BDC 8.153 0 Td ( )Tj EMC 0.218 0 Td [(\200)0.5(.)0.5(\204)0.5(.)0.6( \200)0.5(\024)0.6(\023)0.5(\030)0.5(\024)0.5(\f)0.5(\t)0.5( )0.5(\007)0.5(\017)0.5(\026)0.5(\020)0.5(\027)0.5(\024)0.6(\f)0.5(\021)0.5(\017)0.5(\022)0.5(\017)0.5( )0.5(\017)]TJ /Span<>> BDC 12.197 0 Td ( )Tj EMC 0.218 0 Td [(\035)0.5(\036)0.5(\004)0.5(\036)0.6(\027)0.5(\017)0.5(\016)0.5( )0.5(\024)0.5(\f)0.5(\021)0.5(\030)0.5(\024)0.5(\020)0.6(\024)0.5( \007)0.6(\017)0.5(\r)0.5(\036)0.5(\030)0.5(\021)0.5(\017)0.5(\022)0.5(\031)0.5(\035)0.6(\017)0.5(\021)0.5(\026)20( )]TJ 0.023 Tc -0.02 Tw -43.086 -1.2 Td (\024\002\024\007\024\004\027\024\005 \022\017\001\022\017 \(\024\002\024\ \030 \035\017\021\036\030\026\021\031\030\t\). )Tj /T1_1 1 Tf -0.023 Tw (\r\034\027\034\f\033\034\021\035\034\027\034\013\022\030.)Tj /T1_3 1 Tf -0.02 Tw ( 2025; \021.)Tj /Span<>> BDC ( )Tj EMC (24, \223)Tj /Span<>> BDC ( )Tj EMC (4, \f.)Tj /Span<>> BDC ( )Tj EMC (201\226208. https://doi.org/10.33878/2073-7556-2025-)Tj -0.023 Tw 0 -1.2 TD (24-4-201-208)Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 0 Tc 0.023 Tw 18 0 0 18 119.6624 413.7639 Tm [(Issues of\022)-23.3(diagnosis and tr)31(eatment of\022)-23.3(acute )]TJ 1.755 -1.167 Td [(div)12(er)-20(ticulitis of\022)-23.3(th)11(e colon \(r)31(e)11(vie)11.1(w\))]TJ 0 0 0 1 k /GS1 gs 14 0 0 14 42.5197 368.26 Tm [(Shamil\022)-23.2(V)62(.\022)-23.3(Timerbulatov)21.1(, Aigul\022)-23.3(R.\022)-23.2(Gafar)20(ov)10(a, Vil\022)-23.2(M.\022)-23.3(Timerbulatov)]TJ 10 0 0 10 42.5197 350.5907 Tm [(Bashkir State Medical Univ)12(er)20(sit)-19.9(y of\022)-23.3(th)11(e Ministr)-30.9(y of\022)-23.3(Health of\022)-23.2(th)11(e Russian F)20(eder)21(ation \(Lenin\022)-23.2(st., 3, Ufa, 450008, )]TJ 0 Tw T* (Russia\))Tj /T1_1 1 Tf 0.015 Tw 9 0 0 9 90.7087 320.0868 Tm [(The literature revie)10.1(w highlights moder)-13.9(n app)46(roaches to)]TJ /Span<>> BDC ( )Tj EMC (the diagnosis and choice of)Tj /Span<>> BDC ( )Tj EMC [(treatment for acute div)13(er)-40(ticulitis )]TJ -0.009 Tw 0 -1.111 TD (of)Tj /Span<>> BDC ( )Tj EMC (the colon. The)Tj /Span<>> BDC ( )Tj EMC [(signif)-42.9(icance and ef)-39.9(fectiv)13(eness of)]TJ /Span<>> BDC ( )Tj EMC [(clinical laborator)-42.9(y and imaging research methods are considered. )]TJ 0.06 Tw T* [(Ultrasound and com)16(puted tomog)14(raph)12(y are cur)-16(rently the)]TJ /Span<>> BDC ( )Tj EMC [(most accurate diagnostic methods for acute div)13(er)-40(ticulitis, )]TJ 0.087 Tw T* [(with )0.5(a)]TJ /Span<>> BDC ( )Tj EMC 2.823 0 Td [(sensitivity )0.6(of)]TJ /Span<>> BDC ( )Tj EMC 5.398 0 Td [(85\22697% )0.5(and )0.5(a)]TJ /Span<>> BDC ( )Tj EMC 6.162 0 Td [(specif)-42.9(icity )0.5(of)]TJ /Span<>> BDC ( )Tj EMC 5.41 0 Td [(90\22699%. )0.5(Special )0.6(attention )0.6(is )0.5(paid )0.5(to)]TJ /Span<>> BDC ( )Tj EMC 15.055 0 Td [(surgical )0.5(tactics )0.5(in )0.6(com)16.1(pli)]TJ 0 Tw (-)Tj 0.04 Tw -34.848 -1.111 Td [(cated div)13.1(er)-40(ticulitis, )0.5(the)]TJ /Span<>> BDC ( )Tj EMC [(role )0.5(and place of)]TJ /Span<>> BDC ( )Tj EMC 16.221 0 Td [(percutaneous )0.5(inter)-42(v)13(entions, )0.5(v)16(ar)-37(ious )0.5(op)13(tions for )0.5(colon resection, including )]TJ 0.023 Tw -16.221 -1.111 Td (laparoscopic access.)Tj /T1_2 1 Tf 0.01 Tc -0.01 Tw 8 0 0 8 42.5596 254.8175 Tm [(KEYW)22(ORDS:)]TJ /T1_1 1 Tf 0 Tc 0.003 Tw 4.948 0 Td [( acute div)13(er)-39.9(ticulitis, com)16.1(plicated div)13(er)-39.9(ticulitis, diagnosis, conser)-41.9(v)16(ativ)13(e treatment, minimally in)11(v)15.9(asiv)13.1(e methods, surgical inter)-42(v)13(entions.)]TJ /T1_2 1 Tf 0.01 Tc 0.018 Tw -4.948 -1.909 Td [(C)19(ONFL)-33(ICT)5( OF)]TJ /Span<>> BDC 5.312 0 Td ( )Tj EMC [(INTE)25(REST)61.9(:)]TJ /T1_1 1 Tf 0 Tc 0.023 Tw 4.559 0 Td ( the)Tj /Span<>> BDC ( )Tj EMC [(authors declare that there is no conf)-22(lict of)]TJ /Span<>> BDC ( )Tj EMC (interest)Tj /T1_2 1 Tf 0.01 Tc -0.01 Tw -9.871 -1.909 Td [(FIN)16(A)31(N)23(CIN)23(G:)]TJ /T1_1 1 Tf 0 Tc 0.023 Tw 4.966 0 Td ( there are no sources of)Tj /Span<>> BDC ( )Tj EMC [(f)-43(inancing)]TJ /T1_2 1 Tf 0.037 Tc -0.033 Tw -4.966 -2.617 Td [(F)3.2(O)-4.6(R)8.7( C)-17.5(I)-15.6(T)45.4(A)37.5(T)-24.4(I)-1.3(ON:)]TJ /T1_3 1 Tf 0.023 Tc -0.024 Tw 6.411 0 Td [( T)-17.3(i)-3.2(m)-16.6(e)-12.1(r)-28.4(b)-15.9(u)-8.4(l)-37.7(a)-18.3(t)-21.8(o)-10.3(v)]TJ /Span<>> BDC ( )Tj EMC [(S)-10.3(h)-5.1(.)40.6(V)39.7(.)-23.5(, G)-13.1(a)-14.4(f)-39.2(a)-10.2(r)-15.7(o)-10.4(v)-28.4(a)]TJ /Span<>> BDC ( )Tj EMC [(A)-23(.R)-21.4(.)-23.5(, T)-17.3(i)-3.2(m)-16.6(e)-12(r)-28.5(b)-15.9(u)-8.4(l)-37.7(a)-18.2(t)-21.9(o)-10.3(v)]TJ /Span<>> BDC ( )Tj EMC [(V)39.7(.)-7.3(M)-7.1(. I)-29.9(s)-22.3(s)-8.8(u)-12.5(e)-22.8(s o)-12.1(f)]TJ /Span<>> BDC ( )Tj EMC [(d)-15.8(i)-5.1(a)-10.8(g)-8.8(n)-11.9(o)-15.8(s)-26.1(i)-7.4(s a)-7.6(n)-14.5(d t)-30.8(r)-19.1(e)-13(a)-18.2(t)-26.1(m)-16.6(e)-11.5(n)-17.3(t o)-12.1(f)]TJ /Span<>> BDC ( )Tj EMC [(a)-11.1(c)-12.1(u)-16.3(t)-24.7(e d)-15.8(i)-14.5(v)-18.7(e)-12.1(r)-59.6(t)-46.2(i)-5(c)-12.1(u)-8.4(l)-16.7(i)-15.8(t)-46.2(i)-7.4(s o)-12.1(f)]TJ /Span<>> BDC ( )Tj EMC [(t)-26.1(h)-15.1(e)23( )]TJ 0.024 Tw -6.416 -1.2 Td [(c)-6.5(o)-15.6(l)-20.9(o)-9.2(n \()39.2(r)-19.1(e)-15.8(v)-51.8(i)-11(e)-12.5(w)19.6(\))10.4(. )]TJ /T1_1 1 Tf 0.033 Tc -0.033 Tw [(K)13.9(ol)3.6(op)2.4(r)3.1(o)3.5(k)-19.2(t)2.2(ol)3.7(o)-3.3(g)-13.2(i)6.7(a)5.8(.)]TJ /T1_3 1 Tf 0.032 Tc 0.015 Tw 13.847 0 Td [( 20)5.2(2)7.6(5)32.3(;)18.8(2)17.8(4)-4.5(\()49.1(4)39.3(\))23.5(:)11.3(20)7.5(1)35.4(\226)20.7(20)-14.4(8)-2.1(.)8.7( \()8.1(i)5.9(n)8.7( R)2.5(u)-12.9(s)-13.3(s)-6.5(.)52.2(\))19.4(.)8.7( h)-8.2(t)-40.4(t)-20.3(p)-9.8(s)1.1(:)10.9(/)93.7(/)45.4(d)-2.1(o)-3.5(i)8.8(.)11.7(o)-2.8(r)-7.7(g)-13.8(/)20.2(1)23(0)15.5(.)3.4(3)16.9(3)-6.9(8)10.3(7)13.6(8)9(/)16.9(20)18.3(7)7.1(3)-4.3(-)50.2(7)19.7(5)9.4(56)-17.7(-)18.7(20)5.2(2)7.6(5)-14.5(-)18.7(2)17.8(4)-19.5(-)-21.3(4)-19.4(-)18.7(20)7.5(1)35.8(-)18.8(20)-14.4(8)]TJ /T1_2 1 Tf 0.01 Tc 0.239 Tw -13.842 -2.617 Td [(\021\024\027\030\026)5( \024\033\023)5( \t\030\027\030\t\032\026\037\032:)]TJ /T1_1 1 Tf 0 Tc 0.244 Tw 11.018 0 Td ( \223\037\017\037\033\034\036\037 \205\004\013\023\027\003 \213\037\b\022\ \021\034\036\020\037, \216\223\210\240\215 \240 \210\223\214\215 \214\022\ \020\031\b\033\037\036\037 \213\034\024\024\022\022, \023\027. \231\016\020\ \022\020\037, \b.)Tj /Span<>> BDC ( )Tj EMC (3, \215\017\037, 450008, \213\034\024\024\022\030; )Tj 0.023 Tw -11.023 -1.2 Td (e-mail:)Tj /Span<>> BDC ( )Tj EMC (argafarova@yandex.ru)Tj /T1_2 1 Tf 0.01 Tc 0.068 Tw 0.005 -1.2 Td [(ADDRESS)5( F)13(OR)5( C)19(ORRESPONDEN)23(CE:)]TJ /T1_1 1 Tf 0 Tc 0.073 Tw 14.152 0 Td [( Aigul R. Gafarov)16.1(a, Bashkir S)28(tate Medical U)22(niv)13(ersity)42(, Lenin st., 3, Ufa, 450008, R)22(ussia; e-mail: arg)12(afarov)16.1(a@)]TJ 0 Tw -14.157 -1.2 Td [(yande)-15(x.ru)]TJ 0 -2.792 TD (\n\037\035\037 \f\034\024\035\023\f\027\016\020\022\030)Tj /Span<>> BDC ( )Tj EMC (\227 25.06.2025)Tj /Span<>> BDC ( )Tj EMC 19.488 0 Td (\t\034\024\027\016 \b\034\033\037\025\034\035\021\022)Tj /Span<>> BDC ( )Tj EMC (\227 27.08.2025)Tj /Span<>> BDC ( )Tj EMC 18.78 0 Td (\t\033\022\020\030\035\034 \021)Tj /Span<>> BDC ( )Tj EMC (\f\023\025\027\022\021\037\007\022\022)Tj /Span<>> BDC ( )Tj EMC (\227 10.11.2025)Tj ( )Tj -38.268 -1.375 Td (Received)Tj /Span<>> BDC ( )Tj EMC (\227 25.06.2025)Tj /Span<>> BDC ( )Tj EMC 19.488 0 Td (Revised)Tj /Span<>> BDC ( )Tj EMC (\227 27.08.2025)Tj /Span<>> BDC ( )Tj EMC 18.78 0 Td (Accepted for publication)Tj /Span<>> BDC ( )Tj EMC (\227 10.11.2025)Tj ET 1 0.68 0 0.12 k /GS0 gs q 1 0 0 1 42.5197 610.1533 cm 0 0 m 0 0 l 0 -11.339 l 42.52 -11.339 l 42.52 0 l h f Q BT 0 0 0 0 k /T1_2 1 Tf 9 0 0 9 47.6607 601.226 Tm (\027\030\013\016\n\030)Tj ET 1 0.68 0 0.12 k q 1 0 0 1 42.5197 328.5913 cm 0 0 m 0 0 l 0 -11.339 l 42.52 -11.339 l 42.52 0 l h f Q BT 0 0 0 0 k /T1_2 1 Tf 9 0 0 9 45.2263 319.664 Tm (ABSTRACT)Tj 1 0.68 0 0.12 k /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\206)10(\002\036\033 \035\030\032\003\033)30(\n)42(\032)-21(\230\033\241)]TJ 57.136 0 Td (REVIEW)Tj /T1_4 1 Tf 25 0 0 25 505.4897 56.0378 Tm (201)Tj ET q 0 g 0 G /Fm1 Do Q 0 0 0 0 k 368.504 725.67 59.155 11.338 re f /PlacedPDF /MC0 BDC q 369.135 736.808 m 368.896 736.808 368.703 736.616 368.703 736.376 c 368.703 736.376 l 368.703 726.285 l 368.703 726.045 368.896 725.853 369.135 725.853 c 369.135 725.853 l 427.035 725.853 l 427.273 725.853 427.469 726.045 427.469 726.285 c 427.469 726.285 l 427.469 736.376 l 427.469 736.616 427.273 736.808 427.035 736.808 c 427.035 736.808 l h W n q 0 g -0.0000005 -10.9560913 -10.9560913 0.0000005 398.0855785 736.8086309 cm BX /Sh0 sh EX Q Q q 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T)49.9(r)-32.9(ansper)-37(ineal r)-24(ec)]TJ 0 Tw (-)Tj -0.03 Tw -2.296 -1.25 Td [(t)17(o)-16(cele )0.5(r)-24(ep)32(air: )0.6(a)]TJ /Span<>> BDC ( )Tj EMC [(sy)-12.9(stema)15(t)-32(ic )0.5(r)-24(ev)-16(iew. )]TJ /T1_1 1 Tf 13.847 0 Td [(A)53(NZ )0.5(J )0.5(Surg)]TJ /T1_0 1 Tf [(. )0.5(2017;87\(10\):773\226779. )]TJ 0 Tw -13.847 -1.25 Td [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1111/ans.14068)Tj 0 0 0 1 k /GS1 gs 0.001 Tc 0.349 Tw -1.847 -1.25 Td (108.)Tj /Span<>> BDC ( )Tj EMC 2.3 0 Td [(Y)40.1(oussef)]TJ /Span<>> BDC ( )Tj EMC (M, Emile)Tj /Span<>> BDC ( )Tj EMC [(SH, T)47.1(habe)-11.9(t)]TJ /Span<>> BDC ( )Tj EMC [(W, e)-11.9(t)]TJ /Span<>> BDC ( )Tj EMC [(al. 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Sur)-31.9(gical )]TJ 0.023 Tw T* [(tr)-24(ea)15(tment of)]TJ /Span<>> BDC ( )Tj EMC [(r)-24(ec)-16(t)17.1(o)-16(cele. )]TJ /T1_1 1 Tf (Khirurgiia \(Mosk)Tj /T1_0 1 Tf (\). 2009;8:38\22640. \(In Russ.\).)Tj 0.009 Tc 0.35 Tw T* (110.)Tj /Span<>> BDC ( )Tj EMC 2.343 0 Td (Oleinik)Tj /Span<>> BDC ( )Tj EMC [(NV, Kr)-37.3(i)-16.3(vchikov)-15.3(a)]TJ /Span<>> BDC ( )Tj EMC [(AP, Y)49.6(ar)-32.3(osh)]TJ /Span<>> BDC ( )Tj EMC [(AL, e)-12.4(t)]TJ /Span<>> BDC ( )Tj EMC [(al. P)34.6(r)-24.3(event)-32.3(ion)9( )]TJ 0 Tc 0.114 Tw -2.343 -1.25 Td (of)Tj /Span<>> BDC ( )Tj EMC [(d)17(y)-13(sp)32.1(ar)-24(eunia when per)-24(for)-16(ming tr)-33(ansv)-15(a)-17(ginal r)-24(ec)-16(t)17(o)-16(cele cor)-24(r)-24(ec)-15.9(t)-32(ion. )]TJ /T1_1 1 Tf 0.005 Tc 0.35 Tw T* [(Inter)-14.1(national )0.5(R)20.9(esearch )0.5(Jour)-14(nal)]TJ /T1_0 1 Tf [(. )0.5(2023;1\(127\):73. )0.5(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs -0.005 Tw 23.358 0 Td (10.23670/)Tj 0 Tc 0 Tw -23.358 -1.25 Td (IRJ.2023.127.155)Tj 0 0 0 1 k /GS1 gs -0.035 Tw T* (111.)Tj /Span<>> BDC ( )Tj EMC 2.296 0 Td [(L)-32(amah)]TJ /Span<>> BDC ( )Tj EMC (M, Ho)Tj /Span<>> BDC ( )Tj EMC [(J, L)35(eicester)]TJ /Span<>> BDC ( )Tj EMC [(RJ. R)13(esul)56(ts of)]TJ /Span<>> BDC ( )Tj EMC [(anter)-37(ior lev)-14.9(a)15(t)17(or)-24(pl)-16(ast)-9.9(y for )]TJ 0 Tw -2.296 -1.25 Td [(r)-24(ec)-16(t)17.1(o)-16(cele. )]TJ /T1_1 1 Tf 0.125 Tw 4.394 0 Td (Colorectal Di)Tj /T1_0 1 Tf [(s. 2001;3\(6\):412\226416. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1046/j.1463-)Tj -4.394 -1.25 Td (1318.2001.00245.x)Tj 0 0 0 1 k /GS1 gs 0.194 Tw T* (112.)Tj /Span<>> BDC ( )Tj EMC 2.296 0 Td [(Maed)42(a)]TJ /Span<>> BDC ( )Tj EMC [(K, Hond)42(a)]TJ /Span<>> BDC ( )Tj EMC [(K, K)25(oide)]TJ /Span<>> BDC ( )Tj EMC [(Y, e)-11.9(t)]TJ /Span<>> BDC ( )Tj EMC (al. Outcomes of)Tj /Span<>> BDC ( )Tj EMC [(T)50(r)-33(ansv)-14.9(a)-17(ginal )]TJ 0.055 Tw -2.296 -1.25 Td [(Anter)-36.9(ior L)35.1(ev)-15(a)15(t)17(or)-24(pl)-16(ast)-9.9(y wi)-23.9(t)-13(h P)10(oster)-37(ior Colpor)-23.9(r)-24(haphy for Sym)10(pt)17(oma)15(t)-32(ic )]TJ 0 Tw T* [(R)13(ec)-16(t)17(o)-16(cele. )]TJ /T1_1 1 Tf 0.013 Tw 4.456 0 Td [(J )0.6(Anus )0.5(R)21.1(ectum )0.6(Colon)]TJ /T1_0 1 Tf [(. )0.6(2021;5\(2\):137\226143. )0.6(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw 18.942 0 Td (10.23922/)Tj -23.399 -1.25 Td [(jar)-32(c.2020-062)]TJ 0 0 0 1 k /GS1 gs 0.075 Tw T* (113.)Tj /Span<>> BDC ( )Tj EMC 2.296 0 Td [(S)-16(hao)]TJ /Span<>> BDC ( )Tj EMC [(Y, F)10(u)]TJ /Span<>> BDC ( )Tj EMC [(YX, W)12(ang)]TJ /Span<>> BDC ( )Tj EMC [(QF, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. 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Appl)-31(ica)15(t)-32(ion of)]TJ /Span<>> BDC ( )Tj EMC [(synt)-13(he)-11.9(t)-32(ic and bio)]TJ 0 Tw (-)Tj 0.239 Tw T* [(l)30(o)-16(gical im)10(pl)-16(ants for f)-28(ix)-11(a)15(t)-32(ion of)]TJ /Span<>> BDC ( )Tj EMC [(r)-23.9(ec)-16(t)17(ov)-15(a)-17(ginal septum in r)-24(ec)-15.9(t)17(o)-16(cele )]TJ 0 Tw T* [(r)-24(ep)32(air. )]TJ /T1_1 1 Tf 0.117 Tw 2.979 0 Td [(Grek)13(ov\237s Bulletin of)]TJ /Span<>> BDC ( )Tj EMC [(Surg)12(er)-43(y)]TJ /T1_0 1 Tf (. 2017;176\(4\):51\22654. \(In Russ.\). )Tj 0 Tw -2.979 -1.25 Td [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.24884/0042-4625-2017-176-4-51-54)Tj 0 0 0 1 k /GS1 gs 0.004 Tw -1.847 -1.25 Td (118.)Tj /Span<>> BDC ( )Tj EMC 2.296 0 Td [(A)-14(br)-33(amov)]TJ /Span<>> BDC ( )Tj EMC (Y, Gandhi)Tj /Span<>> BDC ( )Tj EMC [(S, Goldber)-31.9(g)]TJ /Span<>> BDC ( )Tj EMC [(RP, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. S)-16(i)-23.9(te-spec)-24(if)-28(ic r)-24(ec)-16(t)17(o)-16(cele )]TJ -0.083 Tw -2.296 -1.25 Td [(r)-24(ep)32(air com)10(p)32(ar)-24(ed wi)-24(t)-12.9(h st)15(and)42(ar)-24(d poster)-36.9(ior colpor)-23.9(r)-24(haphy. )]TJ /T1_1 1 Tf (Obstet Gynecol)Tj /T1_0 1 Tf 0 Tw (. )Tj 0.023 Tw T* [(2005;105\(2\):314\226318. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw [(10.1097/01.A)15(OG.0000151990.08019.30)]TJ 0 0 0 1 k /GS1 gs 0.013 Tw T* (119.)Tj /Span<>> BDC ( )Tj EMC 2.296 0 Td (Nieminen)Tj /Span<>> BDC ( )Tj EMC [(K, Hil)56.1(tunen)]TJ /Span<>> BDC ( )Tj EMC [(KM, L)-32(ai)-24(t)-32(inen)]TJ /Span<>> BDC ( )Tj EMC [(J, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. 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endobj 613 0 obj <> endobj 612 0 obj <> endobj 611 0 obj <> endobj 610 0 obj <> endobj 609 0 obj <> endobj 608 0 obj <> endobj 607 0 obj <> endobj 606 0 obj <> endobj 605 0 obj <> endobj 604 0 obj <> endobj 603 0 obj <> endobj 602 0 obj <> endobj 601 0 obj <> endobj 600 0 obj <> endobj 561 0 obj [635 0 R 636 0 R 637 0 R 638 0 R 639 0 R 640 0 R 641 0 R 642 0 R 643 0 R 644 0 R 645 0 R 646 0 R 647 0 R 648 0 R 649 0 R 650 0 R 651 0 R 652 0 R 653 0 R 654 0 R 655 0 R 656 0 R 657 0 R 658 0 R 659 0 R 660 0 R 661 0 R 662 0 R 663 0 R 664 0 R 665 0 R 666 0 R 667 0 R 668 0 R 669 0 R 670 0 R 671 0 R 672 0 R 673 0 R 674 0 R 675 0 R] endobj 562 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\033\016\017)-10(\026)11(\025\212\016\t\016 \200\022\216\016\215\232\021\215: \215\016\201\016\020\ \016\215\215\220\016 \r\025\222\201\025\b\220 \(\025\235\213\025\201\022\ \t\021\026)11(\016\201\001\026)-20(\200\201\220\))]TJ 41.66 0 Td [(Rectocele in females: unr)31(esolv)12(ed issues \(r)31(e)11(vie)11(w\))]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0.085 Tw 8 0 0 8 42.5197 731.2159 Tm (70.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(K)20(w)-12(ak)]TJ /Span<>> BDC ( )Tj EMC (HD, Ju)Tj /Span<>> BDC ( )Tj EMC [(JK. L)-31.9(ap)32(ar)-32(oscopic R)13(ec)-16(t)17(ov)-15(a)-16.9(ginal Sept)15(al R)12.9(ep)32(air wi)-24(t)-13(h)]TJ 0 Tw (-)Tj -0.028 Tw -1.796 -1.25 Td [(out Mesh for Anter)-37(ior R)13(ec)-16(t)17(o)-16(cele. )]TJ /T1_2 1 Tf [(J Minim In)11(v)16(asiv)13(e Surg)]TJ /T1_1 1 Tf (. 2018;21:177\226)Tj 0.023 Tw 0 -1.25 TD [(179. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.7602/jmis.2018.21.4.177)Tj 0 0 0 1 k /GS1 gs 0.002 Tc 0.349 Tw T* (71.)Tj /Span<>> BDC ( )Tj EMC 1.804 0 Td (\215\024\023\024\r)Tj /Span<>> BDC ( )Tj EMC (\202.\202., \025\030\026\f\027\024\023\024\035\034\f\022\026\016)Tj /Span<>> BDC ( )Tj EMC (\236.\200., \205\036\007\024\030\024\r)Tj /Span<>> BDC ( )Tj EMC (\202.\202., \017)Tj /Span<>> BDC ( )Tj EMC [(\f\024\026\r\021.)2( )]TJ 0 Tc 0.22 Tw -1.804 -1.25 Td (\224\024\r\030\036\n\036\027\027\t\036 \f\036\021\004\026\021\t\036 \017\ \n\023\035\026\027\021\t \r)Tj /Span<>> BDC ( )Tj EMC (\b\017\030\031\030\020\017\017 \020\036\027\017\021\026\035\034\027\024\020\ \024 \023\030\024)Tj 0 Tw (-)Tj 0.002 Tc -0.002 Tw T* [(\035)0.5(\026)0.6(\023)0.5(\f)0.6(\026)0.5(.)0.6( )]TJ /T1_2 1 Tf 0.349 Tw 3.228 0 Td [(\205)0.5(\021)0.6(\023)0.5(\001)0.6(\016)0.5(\033)0.6(\024)0.5(\035)0.5(\036)0.6(\034)0.6( \022)]TJ /Span<>> BDC 6.23 0 Td ( )Tj EMC [(\013)0.5(\022)0.6(\020)0.5(\016)0.5(\021)0.6(\034)0.5(\027)0.6(\034)0.5(\013)0.6(\022)0.5(\030)0.6( \207)0.6(\037)0.5(\020)0.6(\021)0.5(\035)0.6(-)0.5(\t)0.6(\016)0.5(\035)0.6(\016)0.5(\033)0.6(\025)0.5(\023)0.6(\033)0.5(\013)0.5(\037)]TJ /T1_1 1 Tf 14.127 0 Td [(.)0.5( 2)0.6(0)0.5(1)0.5(8)0.6(;)0.5(3)0.6(-)]TJ 0 Tc 0.256 Tw -23.585 -1.25 Td [(4:57\22658. / P)10(opov)]TJ /Span<>> BDC ( )Tj EMC [(A.A., Kr)-33(asnopol\246sk)-16.9(aja I.V., F)10(ed)-16(or)-31.9(ov)]TJ /Span<>> BDC ( )Tj EMC [(A.A., e)-12(t)]TJ /Span<>> BDC ( )Tj EMC (al. )Tj 0.187 Tw T* [(S)-16(ovr)-23.9(emennye se)-12(tcha)15.1(t)-10(ye im)10(pl)-16(ant)-9.9(y v hir)-21.9(ur)-32(gi)-16(i geni)-23.9(t)15(al\246no)-16(go p)25(r)-32(ol)-15.9(apsa. )]TJ /T1_2 1 Tf 0.31 Tw T* [(Akusherstv)13(o i ginek)13(ologi)11.1(ja Sankt-P)15(eterburg)12.1(a)]TJ /T1_1 1 Tf (. 2018;3-4:57\22658. \(In )Tj 0 Tw T* (Russ.\).)Tj 0.062 Tw T* (72.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(D\344llenba)-17(ch)]TJ /Span<>> BDC ( )Tj EMC [(P. T)45(o)]TJ /Span<>> BDC ( )Tj EMC [(mesh or no)16.9(t t)17(o)]TJ /Span<>> BDC ( )Tj EMC (mesh: a)Tj /Span<>> BDC ( )Tj EMC [(r)-24(ev)-16(iew of)]TJ /Span<>> BDC ( )Tj EMC [(pel)30(v)-16(ic or)-31.9(gan )]TJ 0.005 Tc 0.35 Tw -1.796 -1.25 Td [(r)-24.4(econstr)-22.4(uc)-16.4(t)-32.4(i)-16.4(ve sur)-32.4(ger)-24.4(y. )]TJ /T1_2 1 Tf [(Int J W)28.6(omens Health.)]TJ /T1_1 1 Tf [( 2015;7:331\226343.)5( )]TJ 0 Tc 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.2147/IJWH.S71236)Tj 0 0 0 1 k /GS1 gs 0.128 Tw -1.847 -1.25 Td (73.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (\236\013\036\027\022\024)Tj /Span<>> BDC ( )Tj EMC (\202.\236., \202\035\036\022\f\026\027\007\030\024\r)Tj /Span<>> BDC ( )Tj EMC (\214.\224., \236\013\036\027\022\024)Tj /Span<>> BDC ( )Tj EMC (\202.\202., \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. Mesh-)Tj 0.158 Tw -1.796 -1.25 Td (\035\017\020\026\021\031\030\027\026\016 \022\024\030\030\036\022\006\017\ \016 \023\030\024\035\026\023\f\026 \026\007\027\036\005 \f\021\036\027\ \022\017 \r\035\026\020\026\035\017\013\026 II\226III )Tj 0.198 Tw T* [(\f\021\036\023\036\027\017 )0.5(\023\030\017)]TJ /Span<>> BDC ( )Tj EMC 5.663 0 Td [(\023\024\n\024\013\017 )0.5(\f\036\021\004\026\021\t\b )0.5(\021\017\021\026\027\024\r\t\b )0.6(\017\n\023\035\026\027\021\026\021\024\r. )]TJ /T1_2 1 Tf 0 Tw 18.464 0 Td (\034\f\033\034\024\032 )Tj 0.013 Tc 0.483 Tw -24.127 -1.25 Td (\013\022\020\016\021\034\027\034\013\022\022, \037\021\023\001\016\033\024\ \035\036\037 \022)Tj /Span<>> BDC ( )Tj EMC (\f\016\033\022\020\037\035\034\027\034\013\022\022)Tj /T1_1 1 Tf (. 2020;19\(3\):14\226)Tj 0.011 Tc 0.424 Tw T* [(21. d)-16.4(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs -0.011 Tw (10.20953/1726-1678-2020-3-14-21)Tj 0 0 0 1 k /GS1 gs 0.424 Tw ( / Ishchenko)Tj /Span<>> BDC ( )Tj EMC [(A.I.,)11( )]TJ 0 Tc 0.245 Tw T* [(Alek)-9.9(sandr)-32(ov)]TJ /Span<>> BDC ( )Tj EMC (L.S., Ishchenko)Tj /Span<>> BDC ( )Tj EMC [(A.A., e)-11.9(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Mesh-l)-30.9(iga)15(tur)-24(e cor)-24(r)-24(ec)-16(t)-31.9(ion )]TJ 0.06 Tw T* (of)Tj /Span<>> BDC ( )Tj EMC [(poster)-37(ior v)-15(a)-17(ginal w)-12(all p)25(r)-32(ol)-16(apse gr)-32.9(ade II\226III using t)-32(i)-24(t)15(anium mesh )]TJ 0 Tw T* [(im)10(pl)-16(ants. )]TJ /T1_2 1 Tf 0.109 Tw 4.128 0 Td [(V)32(op)46(r. ginek)13(ol. akus. per)-36.9(inatol. \(Gynecology, Obstetr)-36.9(ics and )]TJ 0 Tw -4.128 -1.25 Td [(P)15(er)-37(inatology\).)]TJ /T1_1 1 Tf 0.166 Tw [( 2020;19\(3\):14\22621. \(In Russ.\). d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.20953/1726-)Tj T* (1678-2020-3-14-21)Tj 0 0 0 1 k /GS1 gs 0.121 Tw T* (74.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(P)40(ar)-33(aiso)]TJ /Span<>> BDC ( )Tj EMC [(MF, Bar)-24(ber)]TJ /Span<>> BDC ( )Tj EMC (MD, Muir)Tj /Span<>> BDC ( )Tj EMC [(T)-48(W, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. R)13(ec)-16(t)17(o)-16(cele r)-24(ep)32(air: a)]TJ /Span<>> BDC ( )Tj EMC [(r)-33(an)]TJ 0 Tw (-)Tj -0.006 Tw -1.796 -1.25 Td [(d)-16(omized tr)-37(ial of)]TJ /Span<>> BDC ( )Tj EMC [(t)-13(hr)-24(ee sur)-32(gical techniques incl)35.1(uding gr)-33(af)-28(t augment)15(a)]TJ 0 Tw (-)Tj T* [(t)-32(ion. )]TJ /T1_2 1 Tf 0.06 Tw 2.271 0 Td (Am J Obstet Gynecol. )Tj /T1_1 1 Tf [(2006;195\(6\):1762\2261771. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1016/j.)Tj -2.271 -1.25 Td [(ajo)-16(g.2006.07.026)]TJ 0 0 0 1 k /GS1 gs 0.1 Tw T* (75.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(W)-16(i)-24(t)-12.9(ha)-17(gen)]TJ /Span<>> BDC ( )Tj EMC 4.205 0 Td [(MI, )0.5(Mil)-15.9(ani)]TJ /Span<>> BDC ( )Tj EMC 4.373 0 Td [(AL, )0.5(den )0.5(Bo)-16(on)]TJ /Span<>> BDC ( )Tj EMC 5.747 0 Td [(J, )0.5(e)-12(t)]TJ /Span<>> BDC ( )Tj EMC 2.132 0 Td [(al. )0.5(T)50(r)-32(o)-16(car-guided )0.6(mesh )]TJ 0.204 Tw -18.254 -1.25 Td [(com)10(p)32(ar)-24(ed wi)-24(t)-12.9(h convent)-31.9(ional v)-15(a)-17(ginal r)-24(ep)32(air in r)-23.9(ecur)-24(r)-24(ent p)25(r)-32(ol)-16(apse: )]TJ -0.015 Tw T* (a)Tj /Span<>> BDC ( )Tj EMC [(r)-33(and)-16(omized contr)-32(olled tr)-36.9(ial. )]TJ /T1_2 1 Tf (Obstet Gynecol)Tj /T1_1 1 Tf [(. 2011;117\(2 P)15(t 1\):242\226)]TJ 0.023 Tw T* [(250. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw [(10.1097/A)15(OG.0b013e318203e6a5)]TJ 0 0 0 1 k /GS1 gs 0.074 Tw T* (76.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(K)-16(ar)-23.9(r)-33(am)]TJ /Span<>> BDC ( )Tj EMC (M, Maher)Tj /Span<>> BDC ( )Tj EMC [(C. Sur)-32(ger)-24(y for poster)-37(ior v)-15(a)-17(ginal w)-12(all p)25(r)-32(ol)-16(apse. )]TJ /T1_2 1 Tf 0.291 Tw -1.796 -1.25 Td [(Int U)22(rogynecol)]TJ /Span<>> BDC ( )Tj EMC 6.563 0 Td (J)Tj /T1_1 1 Tf [(. 2013;24\(11\):1835\2261841. )0.5(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1007/s00192-)Tj -6.563 -1.25 Td (013-2174-z)Tj 0 0 0 1 k /GS1 gs 0.009 Tc 0.35 Tw T* (77.)Tj /Span<>> BDC ( )Tj EMC 1.833 0 Td [(K)24.7(ont)16.7(o)-16.3(giannis)]TJ /Span<>> BDC ( )Tj EMC [(S, Goul)-31.2(imi)]TJ /Span<>> BDC ( )Tj EMC [(E, Gianni)-24.3(tsas)]TJ /Span<>> BDC ( )Tj EMC [(K. R)12.6(easons for and)9( )]TJ 0 Tc 0.062 Tw -1.833 -1.25 Td [(A)-25(gainst Use of)]TJ /Span<>> BDC ( )Tj EMC [(N)-14(on-absor)-24(bable, Synt)-13(he)-12(t)-32(ic Mesh Dur)-36.9(ing P)30(el)30(v)-16(ic Or)-32(gan )]TJ 0.051 Tw T* [(P)35(r)-32(ol)-16(apse R)13(ep)32(air, A)-25(ccor)-24(ding t)17(o)]TJ /Span<>> BDC ( )Tj EMC [(t)-12.9(he P)35(r)-32(ol)-16(apsed Com)10(p)32(ar)-21.9(tment. )]TJ /T1_2 1 Tf (Adv Ther)Tj /T1_1 1 Tf 0 Tw (. )Tj 0.023 Tw T* [(2017;33\(12\):2139\2262149. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1007/s12325-016-0425-3)Tj 0 0 0 1 k /GS1 gs 0.215 Tw T* (78.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(S)-24(chim)10(pf)]TJ /Span<>> BDC ( )Tj EMC [(MO, A)-13.9(bed)]TJ /Span<>> BDC ( )Tj EMC (H, Sanses)Tj /Span<>> BDC ( )Tj EMC [(T, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. G)20(r)-33(af)-28(t and Mesh Use in )]TJ 0.118 Tw -1.796 -1.25 Td [(T)50(r)-33(ansv)-15(a)-17(ginal )0.6(P)35(r)-32(ol)-16(apse )0.6(R)13(ep)32(air: )0.6(A)]TJ /Span<>> BDC ( )Tj EMC 13.268 0 Td [(Sy)-13(stema)15(t)-32(ic )0.5(R)13(ev)-16(iew. )]TJ /T1_2 1 Tf 8.212 0 Td [(Obstet )0.6(Gynecol)]TJ /T1_1 1 Tf 0 Tw (. )Tj 0.023 Tw -21.479 -1.25 Td [(2016;128\(1\):81\22691. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw [(10.1097/A)15(OG.0000000000001451)]TJ 0 0 0 1 k /GS1 gs 0.094 Tw T* (79.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(G)20(r)-37(imes)]TJ /Span<>> BDC ( )Tj EMC 3.051 0 Td [(CL, )0.5(S)-23.9(chim)10(pf)]TJ /Span<>> BDC ( )Tj EMC 4.999 0 Td [(MO, )0.5(W)-16(iesl)-15.9(ander)]TJ /Span<>> BDC ( )Tj EMC 6.455 0 Td [(CK, )0.5(e)-12(t)]TJ /Span<>> BDC ( )Tj EMC 2.654 0 Td [(al. )0.5(Sur)-31.9(gical )0.5(inter)-31.9(ven)]TJ 0 Tw (-)Tj 0.034 Tw -18.955 -1.25 Td [(t)-32(ions for poster)-36.9(ior com)10(p)32(ar)-21.9(tment p)25(r)-32(ol)-16(apse and )0.5(obstr)-22(uc)-16(ted defeca)15.1(t)-32(ion )]TJ 0.238 Tw T* [(sym)10(pt)17(oms: )0.6(a)]TJ /Span<>> BDC ( )Tj EMC 5.692 0 Td [(sy)-13(stema)15.1(t)-32(ic )0.5(r)-24(ev)-15.9(iew )0.5(wi)-23.9(t)-13(h )0.5(cl)-30.9(inical )0.6(p)25(r)-33(a)-17(c)-16(t)-32(ice )0.6(r)-24(ecommen)]TJ 0 Tw (-)Tj -5.692 -1.25 Td [(d)42(a)15(t)-32(ions. )]TJ /T1_2 1 Tf 0.281 Tw 3.787 0 Td [(Int U)22(rogynecol)]TJ /Span<>> BDC ( )Tj EMC (J)Tj /T1_1 1 Tf [(. 2019;30\(9\):1433\2261454. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1007/)Tj -3.787 -1.25 Td (s00192-019-04001-z)Tj 0 0 0 1 k /GS1 gs 0.278 Tw T* (80.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Dav)-16(is)]TJ /Span<>> BDC ( )Tj EMC [(K, K)25(umar)]TJ /Span<>> BDC ( )Tj EMC [(D. P)10(oster)-36.9(ior pel)30(v)-16(ic fl)30.1(o)-16(or com)10(p)32(ar)-22(tment disor)]TJ 0 Tw 25.49 0 Td (-)Tj 0.002 Tc -0.002 Tw -27.286 -1.25 Td [(der)-9.9(s. )]TJ /T1_2 1 Tf 0.349 Tw 2.571 0 Td [(Best Pract R)21.1(es Clin Obstet Gynaecol)]TJ /T1_1 1 Tf [(. 2005;19\(6\):941\226958.)2.1( )]TJ 0 Tc 0 Tw -2.571 -1.25 Td [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td [(10.1016/j.bpobg)16(yn.2005.08.010)]TJ 0 0 0 1 k /GS1 gs 0.211 Tw -1.847 -1.25 Td (81.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (\216\017\021\026\030\034\016\027)Tj /Span<>> BDC ( )Tj EMC (\202.\206., \206\024\035\024\r\017\027\026)Tj /Span<>> BDC ( )Tj EMC (\202.\202., \200\036\035\017\036\r)Tj /Span<>> BDC ( )Tj EMC (\025.\224., \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. \215\036\030\r\t\005 )Tj 0.108 Tw -1.796 -1.25 Td [(\024\023\t\021 )0.5(\023\030\017\n\036\027\036\027\017\016 )0.5(\030\024\002\024\021-\026\f\f\017\f\021\017\030\024\r\026\027\027\024\005\ )0.6(\r\036\027\021\030\026\035\034\027\024\005 )0.6(\030\036\022\021\024\023\036\022)]TJ 0 Tw (-)Tj 0.281 Tw T* (\f\017\017 \f\036\021\004\026\021\t\n \017\n\023\035\026\027\021\024\n \f\ )Tj /Span<>> BDC ( )Tj EMC (\017\f\023\024\035\034\024\r\026\027\017\036\n \f\017\f\021\036\n\t Sen\ hance)Tj 0 Tw 4.664 0 0 4.664 261.3275 223.8799 Tm (\256)Tj 8 0 0 8 263.6221 221.2159 Tm ( )Tj 0.331 Tw -27.638 -1.25 Td (\r)Tj /Span<>> BDC ( )Tj EMC (\035\036\004\036\027\017\017 \023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\f\017\027\007\030\024\n\024\n \024\002\f\021\030\031\022\021\017\r\027\024\ \005 \007\036\235\036\022\026\006\017\017. )Tj /T1_2 1 Tf 0 Tw T* (\r\034\027\034\f\033\034\021\035\034\027\034\013\022\030)Tj /T1_1 1 Tf 0.321 Tw [(. 2023;22\(4\):89\22698. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.33878/2073-7556-)Tj T* (2023-22-4-89-98)Tj 0 0 0 1 k /GS1 gs 0.116 Tw [( / Khi)-23.9(t)15(ar)-24(y)22(an)]TJ /Span<>> BDC ( )Tj EMC [(A.G., Gol)30(ov)-16(ina)]TJ /Span<>> BDC ( )Tj EMC [(A.A., V)30(el)-31(iev)]TJ /Span<>> BDC ( )Tj EMC [(K.S., e)-11.9(t)]TJ /Span<>> BDC ( )Tj EMC (al. )Tj T* [(T)47(he)]TJ /Span<>> BDC ( )Tj EMC [(f)-28(ir)-9.9(st e)-18(xper)-36.9(ience of)]TJ /Span<>> BDC ( )Tj EMC [(r)-31.9(obo)17(t-assisted vent)15(al mesh r)-23.9(ec)-16(t)17(ope)-18(xy using )]TJ 0.198 Tw T* [(t)-13(he)]TJ /Span<>> BDC ( )Tj EMC (Senhance)Tj 0 Tw 4.664 0 0 4.664 87.6076 173.8799 Tm (\256)Tj 0.198 Tw 8 0 0 8 89.9022 171.2159 Tm [( sy)-13(stem in t)-12.9(he)]TJ /Span<>> BDC ( )Tj EMC [(tr)-23.9(ea)15(tment of)]TJ /Span<>> BDC ( )Tj EMC [(p)32(a)15(t)-32(ients wi)-23.9(t)-13(h obstr)-21.9(uc)]TJ 0 Tw (-)Tj 0.195 Tw -5.923 -1.25 Td [(t)-32(i)-16(ve defeca)15.1(t)-32(ion syndr)-32(ome. )]TJ /T1_2 1 Tf 0 Tw [(K)18(olop)46(roktologia)]TJ /T1_1 1 Tf 0.195 Tw (. 2023;22\(4\):89\22698. \(In )Tj 0.023 Tw T* [(Russ.\). d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.33878/2073-7556-2023-22-4-89-98)Tj 0 0 0 1 k /GS1 gs 0.225 Tw T* (82.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Mar)-37(ino)]TJ /Span<>> BDC ( )Tj EMC [(G, F)10(r)-36.9(iger)-37(io)]TJ /Span<>> BDC ( )Tj EMC [(M, Bar)-24(ba)]TJ /Span<>> BDC ( )Tj EMC [(M, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Na)15(t)-31.9(i)-16(ve T)34.9(issue P)10(oster)-37(ior )]TJ 0.013 Tc 0.474 Tw -1.796 -1.25 Td [(Com)10.2(p)32.1(ar)-21.9(tment R)13.2(ep)32.1(air for Isol)-15.8(a)15.1(ted P)10.1(oster)-36.9(ior V)25.1(a)-16.9(ginal P)35.2(r)-31.9(ol)-15.9(apse:)13( )]TJ 0.019 Tc 0.695 Tw T* [(Ana)14.9(t)16.8(omical and F)9.8(unc)-16.2(t)-32.2(ional Outcomes. )]TJ /T1_2 1 Tf [(Medicina \(K)16.8(aunas\))]TJ /T1_1 1 Tf 0 Tc 0 Tw (. )Tj 0.023 Tw T* [(2022;58\(9\):1152. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw [(10.3390/medic)-24(ina58091152)]TJ 0 0 0 1 k /GS1 gs 0.321 Tw T* (83.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Cundif)-56(f)]TJ /Span<>> BDC ( )Tj EMC [(GW, W)22(eidner)]TJ /Span<>> BDC ( )Tj EMC [(A)16(C, V)-15(isco)]TJ /Span<>> BDC ( )Tj EMC [(A)16(G, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC (al. An)Tj /Span<>> BDC ( )Tj EMC [(ana)15(t)17(omic and )]TJ 0.087 Tw -1.796 -1.25 Td [(func)-16(t)-32(ional assess)26(ment of)]TJ /Span<>> BDC ( )Tj EMC [(t)-12.9(he discr)-23.9(e)-12(te defec)-16(t r)-24(ec)-16(t)17(o)-16(cele r)-23.9(ep)32(air. )]TJ /T1_2 1 Tf (Am J )Tj 0.004 Tw T* (Obstet Gynecol)Tj /T1_1 1 Tf [(. 1998;179\(6 P)15(t 1\):1451\2261456; discussion 1456-1457. )]TJ 0 Tw 29.055 81.25 Td [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1016/s0002-9378\(98\)70009-2)Tj 0 0 0 1 k /GS1 gs 0.011 Tc 0.404 Tw -1.847 -1.25 Td (84.)Tj /Span<>> BDC ( )Tj EMC 1.84 0 Td [(Gl)-15.8(av)-15.9(ind)]TJ /Span<>> BDC ( )Tj EMC [(K, Chr)-36.8(ist)-31.9(iansen)]TJ /Span<>> BDC ( )Tj EMC [(A)16.1(G. S)-15.9(i)-23.8(te-spec)-23.9(if)-27.8(ic colpor)-23.9(r)-23.8(haphy in)11( )]TJ 0 Tc 0.336 Tw -1.84 -1.25 Td [(poster)-37(ior com)10(p)32(ar)-22(tment pel)30(v)-16(ic or)-32(gan p)25(r)-32(ol)-15.9(apse. )]TJ /T1_2 1 Tf [(Int U)22(rogynecol)]TJ /Span<>> BDC ( )Tj EMC (J)Tj /T1_1 1 Tf 0 Tw (. )Tj 0.023 Tw T* [(2016;27\(5\):735\2269. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1007/s00192-015-2870-y)Tj 0 0 0 1 k /GS1 gs 0.149 Tw T* (85.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Ber)-24(ko)-13.9(wi)-24(tz)]TJ /Span<>> BDC ( )Tj EMC (LR, Hudson)Tj /Span<>> BDC ( )Tj EMC [(PL. S)-16(i)-24(te-spec)-24(if)-28(ic poster)-36.9(ior colpor)-23.9(r)-24(haphy )]TJ 0.174 Tw -1.796 -1.25 Td [(and per)-37(ineor)-23.9(r)-24(haphy for )0.5(r)-24(ec)-16(t)17(o)-16(cele. )]TJ /T1_2 1 Tf 14.486 0 Td (J Med Insight)Tj /T1_1 1 Tf (. 2022;2022\(269\). )Tj 0 Tw -14.486 -1.25 Td [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.24296/jomi/269)Tj 0 0 0 1 k /GS1 gs -0.04 Tw -1.847 -1.25 Td (86.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Gl)35(uck)]TJ /Span<>> BDC ( )Tj EMC 2.356 0 Td [(O, )0.5(Ma)15(t)15(ani)]TJ /Span<>> BDC ( )Tj EMC [(D, )0.5(R)11(osen)]TJ /Span<>> BDC ( )Tj EMC [(A, )0.5(e)-12(t)]TJ /Span<>> BDC ( )Tj EMC 9.311 0 Td [(al. )0.5(Sur)-32(gical )0.5(T)50(r)-24(ea)15(tment )0.5(for )0.5(R)13(ec)-16(t)17(o)-16(cele )]TJ 0.287 Tw -13.463 -1.25 Td [(b)12(y P)10(oster)-37(ior Colpor)-24(r)-24(haphy Com)10(p)32(ar)-24(ed t)17(o)]TJ /Span<>> BDC ( )Tj EMC [(S)15(t)15(apled T)50(r)-33(ansanal R)13(ec)-16(t)15(al )]TJ 0 Tw T* [(R)13(esec)-16(t)-32(ion. )]TJ /T1_2 1 Tf 0.023 Tw 4.524 0 Td (J Clin Med)Tj /T1_1 1 Tf [(. 2023;12\(2\):678. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.3390/jcm12020678)Tj 0 0 0 1 k /GS1 gs 0.008 Tc 0.349 Tw -4.524 -1.25 Td (87.)Tj /Span<>> BDC ( )Tj EMC 1.827 0 Td (Maher)Tj /Span<>> BDC ( )Tj EMC [(CF, Qa)15.2(t)15.2(a)10.2(wneh)]TJ /Span<>> BDC ( )Tj EMC (AM, Baessler)Tj /Span<>> BDC ( )Tj EMC [(K, e)-11.8(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Midl)-30.8(ine r)-23.8(ec)-15.8(t)17.2(o)]TJ 0 Tc 0 Tw (-)Tj 0.337 Tw -1.827 -1.25 Td [(v)-15(a)-17(ginal f)16(asc)-23.9(ial pl)-31(ica)15(t)-32(ion for r)-24(ep)32(air of)]TJ /Span<>> BDC ( )Tj EMC [(r)-24(ec)-15.9(t)17(o)-16(cele and obstr)-22(uc)-16(ted )]TJ 0 Tw T* [(defeca)15(t)-32(ion. )]TJ /T1_2 1 Tf 0.046 Tw 4.891 0 Td (Obstet Gynecol)Tj /T1_1 1 Tf [(. 2004;104\(4\):685\226689. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1097/01.)Tj -4.891 -1.25 Td [(A)15(OG.0000139833.48063.03)]TJ 0 0 0 1 k /GS1 gs 0.154 Tw T* (88.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Bedel)Tj /Span<>> BDC ( )Tj EMC [(A, A)-25(gost)-32(inI A, Ne)-12(t)-30(ter)]TJ /Span<>> BDC ( )Tj EMC [(A, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Midl)-30.9(ine r)-23.9(ec)-16(t)17(ov)-15(a)-17(ginal f)16(as)]TJ 0 Tw (-)Tj 0.15 Tw -1.796 -1.25 Td [(c)-24(ial )0.6(pl)-31(ica)15(t)-32(ion: )0.6(Ana)15(t)17(omical )0.6(and )0.5(func)-16(t)-31.9(ional )0.5(outcomes )0.6(a)15(t )0.5(one )0.6(year. )]TJ /T1_2 1 Tf 0 Tw 27.2 0 Td (J )Tj 0.324 Tw -27.2 -1.25 Td [(Gynecol Obstet Hum R)21(ep)46(rod)]TJ /T1_1 1 Tf [(. 2022;51\(4\):102327. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1016/j.)Tj T* [(jo)-16(goh.2022.102327)]TJ 0 0 0 1 k /GS1 gs 0.258 Tw T* (89.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(K)-16(ahn)]TJ /Span<>> BDC ( )Tj EMC [(MA, S)15(t)15.1(ant)17(on)]TJ /Span<>> BDC ( )Tj EMC [(SL. P)10(oster)-36.9(ior colpor)-23.9(r)-24(haphy: i)-24(ts ef)-55.9(fec)-16(ts on )]TJ -0.024 Tw -1.796 -1.25 Td [(bo)-14(wel )0.5(and )0.5(se)-18(xual )0.5(func)-16(t)-32(ion. )]TJ /T1_2 1 Tf 11.027 0 Td [(Br )0.5(J )0.5(Obstet )0.5(Gynaecol)]TJ /T1_1 1 Tf [(. )0.5(1997;104\(1\):82\22686. )]TJ 0 Tw -11.027 -1.25 Td [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1111/j.1471-0528.1997.tb10654.x)Tj 0 0 0 1 k /GS1 gs 0.153 Tw -1.847 -1.25 Td (90.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Bal)-16(a)15(t)15(a)]TJ /Span<>> BDC ( )Tj EMC [(M, El)16(gend)17(y)]TJ /Span<>> BDC ( )Tj EMC (H, Emile)Tj /Span<>> BDC ( )Tj EMC [(SH, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. F)10(unc)-16(t)-31.9(ional Outcome and )]TJ -0.06 Tw -1.796 -1.25 Td [(Se)-18(xual-R)13.1(el)-16(a)15(ted Q)-16(ual)-31(i)-23.9(t)-10(y of)]TJ /Span<>> BDC ( )Tj EMC [(L)-32(ife Af)-27.9(ter T)50(r)-33(ansper)-36.9(ineal V)30(er)-10(sus T)50(r)-32.9(ansv)-15(a)-17(ginal )]TJ 0.091 Tw T* [(R)13(ep)32(air of)]TJ /Span<>> BDC ( )Tj EMC [(Anter)-36.9(ior R)13(ec)-16(t)17(o)-16(cele: A)]TJ /Span<>> BDC ( )Tj EMC [(R)-9.9(and)-16(omized Cl)-31(inical T)50(r)-36.9(ial. )]TJ /T1_2 1 Tf (Dis Colon )Tj 0 Tw T* [(R)21(ectum)]TJ /T1_1 1 Tf -0.04 Tw [(. 2020;63\(4\):527\226537. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1097/DCR.0000000000001595)Tj 0 0 0 1 k /GS1 gs 0.165 Tw T* (91.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(A)-14(bdelnab)12(y)]TJ /Span<>> BDC ( )Tj EMC [(M, F)20(a)15(t)-13(hy)]TJ /Span<>> BDC ( )Tj EMC [(M, A)-14(bd)42(all)-16(ah)]TJ /Span<>> BDC ( )Tj EMC [(E, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. L)-31.9(ap)32(ar)-32(oscopic V)30(entr)-33(al )]TJ 0.015 Tc 0.556 Tw -1.796 -1.25 Td [(Mesh R)12.8(ec)-16.2(t)16.8(ope)-18.2(xy V)29.8(er)-10.1(sus T)49.8(r)-33.2(ansv)-15.2(a)-17.2(ginal P)9.8(oster)-37.2(ior Colpor)-24.2(r)-24.2(haphy)15( )]TJ 0.014 Tc 0.526 Tw T* [(in Mana)-17.3(gement of)]TJ /Span<>> BDC ( )Tj EMC [(Anter)-37.3(ior R)12.7(ec)-16.3(t)16.7(o)-16.3(cele. )]TJ /T1_2 1 Tf (J Gastrointest Surg.)Tj /T1_1 1 Tf 0 Tc 0 Tw 27.638 0 Td ( )Tj 0.023 Tw -27.638 -1.25 Td [(2021;25\(8\):2035\2262046. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1007/s11605-020-04823-z)Tj 0 0 0 1 k /GS1 gs 0.244 Tw T* (92.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(R)13(egad)42(as)]TJ /Span<>> BDC ( )Tj EMC 3.731 0 Td [(FSP, )0.5(Mur)-32.9(ad-R)13(egad)42(as)]TJ /Span<>> BDC ( )Tj EMC 8.64 0 Td [(SM, )0.5(R)11(odr)-37(igues)]TJ /Span<>> BDC ( )Tj EMC 6.289 0 Td [(L)65(V, )0.5(e)-12(t)]TJ /Span<>> BDC ( )Tj EMC 2.848 0 Td [(al. )0.5(Im)10(p)32(a)-17(c)-16(t )]TJ 0.081 Tw -23.303 -1.25 Td (of)Tj /Span<>> BDC ( )Tj EMC [(TRREMS on sym)10(pt)17(oms of)]TJ /Span<>> BDC ( )Tj EMC [(obstr)-21.9(uc)-16(ted defeca)15.1(t)-32(ion due t)17(o)]TJ /Span<>> BDC ( )Tj EMC [(r)-23.9(ec)-16(t)17(o)-16(cele: )]TJ 0.158 Tw T* [(p)25(r)-24(edic)-15.9(t)-32(i)-16(ve f)16(a)-17(c)-16(t)17(or)-9.9(s and outcomes. )]TJ /T1_2 1 Tf [(T)54(ech Colop)46(roctol)]TJ /T1_1 1 Tf (. 2020;24\(1\):65\226)Tj 0.023 Tw T* [(73. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1007/s10151-019-02131-6)Tj 0 0 0 1 k /GS1 gs 0.113 Tw T* (93.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(L)35(eal)]TJ /Span<>> BDC ( )Tj EMC [(VM, R)13(egad)42(as)]TJ /Span<>> BDC ( )Tj EMC [(FS, R)12.9(egad)42(as)]TJ /Span<>> BDC ( )Tj EMC [(SM, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Cl)-31(inical and func)-16(t)-32(ional )]TJ 0.09 Tw -1.796 -1.25 Td [(ev)-15(al)35(ua)15(t)-32(ion of)]TJ /Span<>> BDC ( )Tj EMC [(p)32(a)15(t)-32(ients wi)-24(t)-12.9(h r)-24(ec)-16(t)17(o)-16(cele and mucosal p)25(r)-32(ol)-16(apse tr)-23.9(ea)15(ted )]TJ -0.028 Tw T* [(wi)-24(t)-12.9(h tr)-32.9(ansanal r)-24(ep)32(air of)]TJ /Span<>> BDC ( )Tj EMC [(r)-24(ec)-16(t)17(o)-16(cele and r)-24(ec)-16(t)15(al mucosec)-15.9(t)17(omy wi)-24(t)-13(h a)]TJ /Span<>> BDC ( )Tj EMC (sin)Tj 0 Tw (-)Tj -0.003 Tw T* [(gle c)-23.9(ir)-32(cul)-16(ar st)15(apler \(TRREMS\). )]TJ /T1_2 1 Tf [(T)54(ech Colop)46(roctol)]TJ /T1_1 1 Tf (. 2010;14\(4\):329\226335. )Tj 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1007/s10151-010-0649-1)Tj 0 0 0 1 k /GS1 gs 0.159 Tw -1.847 -1.25 Td (94.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Mahmoud)Tj /Span<>> BDC ( )Tj EMC (SA, Omar)Tj /Span<>> BDC ( )Tj EMC [(W, F)20(ar)-37(id)]TJ /Span<>> BDC ( )Tj EMC [(M. T)50(r)-33(ansanal r)-24(ep)32.1(air for tr)-24(ea)15(tment )]TJ 0.019 Tw -1.796 -1.25 Td (of)Tj /Span<>> BDC ( )Tj EMC [(r)-24(ec)-16(t)17(o)-16(cele in obstr)-21.9(uc)-16(ted def)16(aeca)15(t)-32(ion: manual or st)15(apled. )]TJ /T1_2 1 Tf 0 Tw (Colorectal )Tj T* (Dis)Tj /T1_1 1 Tf 0.023 Tw [(. 2012;14\(1\):104\226110. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1111/j.1463-1318.2010.02502.x)Tj 0 0 0 1 k /GS1 gs 0.302 Tw T* (95.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Khubchand)42(ani)]TJ /Span<>> BDC ( )Tj EMC [(IT, Cl)-16(ancy JP 3r)-24(d, R)11(osen)]TJ /Span<>> BDC ( )Tj EMC [(L, e)-11.9(t)]TJ /Span<>> BDC ( )Tj EMC [(al. End)-16(or)-23.9(ec)-16(t)15(al )]TJ 0.013 Tc 0.494 Tw -1.796 -1.25 Td [(r)-24.4(ep)31.5(air of)]TJ /Span<>> BDC ( )Tj EMC [(r)-24.4(ec)-16.5(t)16.6(o)-16.4(cele r)-24.4(ev)-16.4(isi)-24.4(ted. )]TJ /T1_2 1 Tf (Br J Surg)Tj /T1_1 1 Tf [(. 1997;84\(1\):89\22691.)13( )]TJ 0 Tc 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1046/j.1365-2168.1997.02463.x)Tj 0 0 0 1 k /GS1 gs 0.098 Tw -1.847 -1.25 Td (96.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(F)20(ar)-37(id)]TJ /Span<>> BDC ( )Tj EMC [(M, Madboul)35(y)]TJ /Span<>> BDC ( )Tj EMC (KM, Hussein)Tj /Span<>> BDC ( )Tj EMC [(A, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. R)-10(and)-16(omized contr)-32(olled )]TJ 0.229 Tw -1.796 -1.25 Td [(tr)-37(ial be)-12(t)-32(ween per)-36.9(ineal and anal r)-23.9(ep)32(air)-10(s of)]TJ /Span<>> BDC ( )Tj EMC [(r)-23.9(ec)-16(t)17(o)-16(cele in obstr)-22(uc)-16(t)]TJ 0 Tw (-)Tj 0.247 Tw T* [(ed defeca)15(t)-32(ion. )]TJ /T1_2 1 Tf [(W)29(orld J Surg)]TJ /T1_1 1 Tf [(. 2010;34\(4\):822\226829. d)-15.9(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1007/)Tj T* (s00268-010-0390-y)Tj 0 0 0 1 k /GS1 gs 0.015 Tc 0.564 Tw T* (97.)Tj /Span<>> BDC ( )Tj EMC 1.858 0 Td (\207\017\030\033\022\024\r)Tj /Span<>> BDC ( )Tj EMC (\210.\204., \204\031\007\030\024\r)Tj /Span<>> BDC ( )Tj EMC 11.48 0 Td [(\202.\202., )0.5(\025\024\f\021\026\030\036\r)]TJ /Span<>> BDC ( )Tj EMC (\236.\200., \017)Tj /Span<>> BDC ( )Tj EMC 11.673 0 Td [(\f\024\026\r\021.)15( )]TJ 0.018 Tc 0.666 Tw -25.011 -1.25 Td (\202\027\026\021\024\n\017\004\036\f\022\017\036 \017)Tj /Span<>> BDC ( )Tj EMC (\235\031\027\022\006\017\024\027\026\035\034\027\t\036 \030\036\031\035\ \034\021\026\021\t \b\017\030\031\030\020\017\004\036)Tj 0 Tc 0 Tw (-)Tj 0.015 Tc 0.558 Tw T* (\f\022\024\020\024 \035\036\004\036\027\017\016 \022\024\n\023\035\036\022\ \f\027\024\020\024 \030\036\022\021\024\006\036\035\036. )Tj /T1_2 1 Tf -0.015 Tw (\r\034\027\034\f\033\034\021\035\034\027\034\013\022\030.)Tj /T1_1 1 Tf 0 Tc 0 Tw 27.638 0 Td ( )Tj 0.005 Tc 0.35 Tw -27.638 -1.25 Td [(2024;23\(4\):24\22630. d)-16.2(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs -0.005 Tw (10.33878/2073-7556-2024-23-4-24-30)Tj 0 0 0 1 k /GS1 gs 0 Tc 0.355 Tw ( / )Tj 0.252 Tw T* [(Bir)-24(yukov)]TJ /Span<>> BDC ( )Tj EMC 4.003 0 Td [(O.M., )0.5(Mudr)-32(ov)]TJ /Span<>> BDC ( )Tj EMC [(A.A., )0.5(K)25(ost)15(ar)-23.9(ev)]TJ /Span<>> BDC ( )Tj EMC [(I.V., a)15(t )0.5(al. 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A)Tj /Span<>> BDC ( )Tj EMC [(tr)-33(ansanal p)25(r)-31.9(o)-16(cedur)-24(e using T)25(S)-21(T )]TJ 0.156 Tw -1.796 -1.25 Td [(S)-21(T)35(ARR Pl)35.1(us for t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(tr)-23.9(ea)15(tment of)]TJ /Span<>> BDC ( )Tj EMC [(Obstr)-22(uc)-16(ted Defeca)15.1(t)-32(ion Syndr)-32(ome: )]TJ 0.328 Tw T* [(\247A mid-ter)-15.9(m stud)17(y\246. )]TJ /T1_2 1 Tf (Int J Surg)Tj /T1_1 1 Tf [(. 2016;32:58\22664. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1016/j.)Tj T* (ijsu.2016.06.039)Tj 0 0 0 1 k /GS1 gs 0.111 Tw T* (99.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Naldini)Tj /Span<>> BDC ( )Tj EMC [(G, F)20(abiani)]TJ /Span<>> BDC ( )Tj EMC (B, Menconi)Tj /Span<>> BDC ( )Tj EMC [(C, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. 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8 0 0 8 70.8661 731.2159 Tm [(Infl)35(uences t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(E)35(xp)25(r)-23.9(ession of)]TJ /Span<>> BDC ( )Tj EMC [(E)35(xtr)-32.9(a)-17(cell)35(ul)-16(ar Ma)15(tr)-37(ix and Cell A)15.1(dhesion )]TJ 0.141 Tw 0 -1.25 TD [(P)35(r)-32(o)17(teins in V)25(a)-17(ginal Cells Der)-37(i)-16(ved fr)-32(om P)35(r)-24(emenop)32(ausal W)20(omen wi)-24(t)-13(h )]TJ -0.049 Tw T* [(Sever)-23.9(e P)30(el)30.1(v)-16(ic )0.5(Or)-32(gan )0.5(P)35(r)-32(ol)-16(apse. )]TJ /T1_1 1 Tf 11.834 0 Td [(R)21(ep)46(roductiv)13.1(e Sciences.)]TJ /T1_0 1 Tf [( )0.5(2016;23\(8\):978\226)]TJ 0.023 Tw -11.834 -1.25 Td [(992. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1177/1933719115625844)Tj 0 0 0 1 k /GS1 gs 0.09 Tw T* (40.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(R)-10(ashidi)]TJ /Span<>> BDC ( )Tj EMC [(F, Mir)-32(ghafour)-31.9(v)-15(and)]TJ /Span<>> BDC ( )Tj EMC [(M. P)30(el)30.1(v)-16(ic fl)30(o)-16(or disor)-24(der and r)-24(elev)-14.9(ant )]TJ 0.255 Tw -1.796 -1.25 Td [(f)16(a)-17(c)-16(t)17(or)-9.9(s in Ir)-32.9(anian w)-14(omen of)]TJ /Span<>> BDC ( )Tj EMC [(r)-24(ep)25(r)-32(oduc)-16(t)-32(i)-16(ve a)-16.9(ge: a)]TJ /Span<>> BDC ( )Tj EMC [(cr)-31.9(oss-sec)-16(t)-32(ional )]TJ 0 Tw T* [(stud)17(y. )]TJ /T1_1 1 Tf 0.228 Tw 2.943 0 Td [(BMC )0.5(W)29(omens )0.5(Health.)]TJ /T1_0 1 Tf [( )0.5(2023;23\(1\):71. )0.5(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw 17.714 0 Td (10.1186/s12905-)Tj -20.658 -1.25 Td (023-02226-1)Tj 0 0 0 1 k /GS1 gs -0.003 Tw T* (41.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(de Ol)-31(i)-16(veir)-33(a)]TJ /Span<>> BDC ( )Tj EMC [(MS, Cav)-15(al)16(cant)-32(i Gde)]TJ /Span<>> BDC ( )Tj EMC [(A, d)42(a Cost)15.1(a)]TJ /Span<>> BDC ( )Tj EMC [(AA. Na)15(t)-32(i)-16(ve v)-15(a)-17(ginal t)-32(is)]TJ 0 Tw (-)Tj 0.066 Tw -1.796 -1.25 Td [(sue r)-24(ep)32(air for geni)-24(t)15.1(al p)24.9(r)-31.9(ol)-16(apse sur)-32(gical tr)-24(ea)15(tment: a)]TJ /Span<>> BDC ( )Tj EMC (minimum of)Tj /Span<>> BDC ( )Tj EMC (30 )Tj 0.01 Tw T* [(mont)-13(hs )0.6(of)]TJ /Span<>> BDC ( )Tj EMC 4.313 0 Td [(r)-24(esul)56.1(ts. )]TJ /T1_1 1 Tf 3.195 0 Td [(Eur )0.5(J )0.6(Obstet )0.6(Gynecol )0.6(R)21(ep)46(rod )0.5(Biol.)]TJ /T1_0 1 Tf [( )0.5(2016;201:75\22678. )]TJ 0 Tw -7.508 -1.25 Td [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td [(10.1016/j.ejo)-15.9(gr)-24(b.2016.03.020)]TJ 0 0 0 1 k /GS1 gs 0.339 Tw -1.847 -1.25 Td (42.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(P)30(er)-10(su)]TJ /Span<>> BDC ( )Tj EMC 2.751 0 Td [(C, )0.5(Chapple)]TJ /Span<>> BDC ( )Tj EMC 4.974 0 Td [(CR, )0.5(Cauni)]TJ /Span<>> BDC ( )Tj EMC 4.568 0 Td [(V, )0.5(e)-12(t)]TJ /Span<>> BDC ( )Tj EMC 2.659 0 Td [(al. )0.5(P)30(el)30(v)-15.9(ic )0.5(Or)-32(gan )0.5(P)35(r)-32(ol)-16(apse )]TJ 0.03 Tw -16.748 -1.25 Td [(Q)-16(uant)-32(if)-27.9(ica)15(t)-32(ion Sy)-13(stem \(POP-Q\))]TJ /Span<>> BDC ( )Tj EMC (\227 a)Tj /Span<>> BDC ( )Tj EMC [(new er)-33(a in pel)30(v)-16(ic p)25(r)-32(ol)-15.9(apse st)15(a)-17(g)]TJ 0 Tw (-)Tj T* (ing. )Tj /T1_1 1 Tf 0.217 Tw 2.044 0 Td (J Med Life)Tj /T1_0 1 Tf [(. 2011;4\(1\):75\22681. ht)-30(tps://www.ncbi.nlm.nih.gov/)]TJ 0 Tw -2.044 -1.25 Td [(pmc/ar)-22(t)-31.9(icles/PMC3056425)]TJ 0.002 Tw T* (43.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Eller)-23.9(kmann)]TJ /Span<>> BDC ( )Tj EMC [(RM, Cundif)-56(f)]TJ /Span<>> BDC ( )Tj EMC [(GW, Mel)-31(ick)]TJ /Span<>> BDC ( )Tj EMC [(CF, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Cor)-24(r)-24(el)-15.9(a)15(t)-32(ion of)]TJ /Span<>> BDC ( )Tj EMC [(sym)10(p)]TJ 0 Tw (-)Tj 0.259 Tw -1.796 -1.25 Td [(t)17(oms wi)-24(t)-12.9(h l)30(o)-16(ca)15(t)-32(ion and sever)-37(i)-24(t)-9.9(y of)]TJ /Span<>> BDC ( )Tj EMC [(pel)30.1(v)-16(ic or)-32(gan p)25(r)-32(ol)-16(apse. )]TJ /T1_1 1 Tf (Am J )Tj 0.007 Tc 0.35 Tw T* (Obstet Gynecol.)Tj /T1_0 1 Tf [( 2001;185\(6\):1332\2261337; discussion 1337-1338.)7.1( )]TJ 0 Tc 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1067/mob.2001.119078)Tj 0 0 0 1 k /GS1 gs -0.032 Tw -1.847 -1.25 Td (44.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Camer)-32(on)]TJ /Span<>> BDC ( )Tj EMC [(AP, Smi)-24(t)-13(h)]TJ /Span<>> BDC ( )Tj EMC [(AR, L)-32(ai)]TJ /Span<>> BDC ( )Tj EMC [(HH, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Bo)-14(wel func)-16(t)-31.9(ion, se)-17.9(xual func)]TJ 0 Tw (-)Tj -0.029 Tw -1.796 -1.25 Td [(t)-32(ion, and sym)10(pt)17(oms of)]TJ /Span<>> BDC ( )Tj EMC [(pel)30(v)-15.9(ic or)-32(gan p)25(r)-32(ol)-16(apse in w)-14(omen wi)-24(t)-13(h and wi)-24(t)-13(h)]TJ 0 Tw (-)Tj -0.009 Tw T* [(out ur)-37(inar)-23.9(y incont)-31.9(inence. )]TJ /T1_1 1 Tf [(N)18(eurourol U)22(rodyn)]TJ /T1_0 1 Tf (. 2018;37\(8\):2586\2262596. )Tj 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1002/nau.23587)Tj 0 0 0 1 k /GS1 gs 0.01 Tc 0.354 Tw -1.847 -1.25 Td [(4)0.5(5)0.6(.)]TJ /Span<>> BDC 1.324 0 Td ( )Tj EMC 0.509 0 Td [(I)0.5(g)0.6(l)0.5(e)0.5(s)0.6(i)0.5(a)]TJ /Span<>> BDC 2.797 0 Td ( )Tj EMC [(C)0.5(B)0.6(,)0.5( S)0.5(m)0.5(i)-23.4(t)-12.5(h)0.5(l)-30.4(i)0.5(n)0.6(g)]TJ /Span<>> BDC 6.465 0 Td ( )Tj EMC [(K)0.5(R)0.5(.)0.6( P)30.5(e)0.5(l)30.6(v)-15.5(i)0.6(c)0.5( O)0.5(r)-31.5(g)0.6(a)0.5(n)0.5( P)35.5(r)-31.4(o)0.5(l)-15.5(a)0.6(p)0.5(s)0.5(e)0.6(.)0.5( )]TJ /T1_1 1 Tf [(A)0.5(m)0.5( F)15.5(a)0.6(m)10( )]TJ 0.006 Tc -0.006 Tw -11.096 -1.25 Td [(Ph)11.8(ysician)]TJ /T1_0 1 Tf 0.35 Tw [(. 2017;96\(3\):179\226185. ht)-30.2(tps://www.aafp.or)-32.1(g/pubs/afp/)]TJ 0 Tc 0 Tw T* (issues/2017/0801/p179.html)Tj 0.015 Tw T* (46.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Bar)-24(ber)]TJ /Span<>> BDC ( )Tj EMC [(MD, W)12(al)56(ter)-10(s)]TJ /Span<>> BDC ( )Tj EMC [(MD, Cundif)-55.9(f)]TJ /Span<>> BDC ( )Tj EMC [(GW. R)13(esponsi)-16(veness of)]TJ /Span<>> BDC ( )Tj EMC [(t)-13(he P)30(el)30(v)-15.9(ic )]TJ -0.035 Tw -1.796 -1.25 Td [(Fl)30(o)-16(or Distr)-23.9(ess Invent)17(or)-24(y \(PFDI\) and P)30(el)30(v)-16(ic Fl)30(o)-16(or Im)10(p)32(a)-16.9(c)-16(t Q)-16(uest)-32(ionnair)-23.9(e )]TJ 0.052 Tw T* [(\(PFIQ\) )0.5(in )0.5(w)-14(omen )0.5(under)-31.9(going v)-14.9(a)-17(ginal )0.5(sur)-32(ger)-24(y )0.5(and )0.5(pessar)-23.9(y )0.5(tr)-24(ea)15(tment )]TJ 0.102 Tw T* [(for pel)30(v)-15.9(ic or)-32(gan p)25(r)-32(ol)-16(apse. )]TJ /T1_1 1 Tf (Am J Obstet Gynecol. )Tj /T1_0 1 Tf 0 Tw (2006;194\(5\):1492\226)Tj 0.023 Tw T* [(1498. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw [(10.1016/j.ajo)-15.9(g.2006.01.076)]TJ 0 0 0 1 k /GS1 gs 0.276 Tw T* (47.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(R)11(or)-22(t)-24(vei)-23.9(t)]TJ /Span<>> BDC ( )Tj EMC 3.803 0 Td [(G, )0.5(Dal)56.1(t)-24(vei)-24(t)]TJ /Span<>> BDC ( )Tj EMC 4.903 0 Td [(AK, )0.6(Hannest)15(ad)]TJ /Span<>> BDC ( )Tj EMC 6.542 0 Td [(YS, )0.5(e)-11.9(t)]TJ /Span<>> BDC ( )Tj EMC 2.977 0 Td [(al. )0.6(U)15(r)-37(inar)-24(y )0.6(incon)]TJ 0 Tw (-)Tj 0.187 Tw -20.021 -1.25 Td [(t)-32(inence af)-28(ter v)-14.9(a)-17.1(ginal del)-31(i)-16(ver)-23.9(y or cesar)-23.9(ean sec)-16(t)-32(ion. )]TJ /T1_1 1 Tf [(N Eng)13(l J Med)]TJ /T1_0 1 Tf 0 Tw (. )Tj 0.023 Tw T* [(2003;348\(10\):900\226907. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw [(10.1056/NEJM)-23.9(oa021788)]TJ 0 0 0 1 k /GS1 gs 0.111 Tw T* (48.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Car)-30(l)-31(in)]TJ /Span<>> BDC ( )Tj EMC [(GL, M)-24(or)-31.9(genbesser)]TJ /Span<>> BDC ( )Tj EMC [(R, Kimber)-32(ger)]TJ /Span<>> BDC ( )Tj EMC [(O, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Does t)-13(he)]TJ /Span<>> BDC ( )Tj EMC (choice )Tj 0.341 Tw -1.796 -1.25 Td (of)Tj /Span<>> BDC ( )Tj EMC [(pel)30(v)-16(ic or)-32(gan p)25(r)-32(ol)-16(apse tr)-24(ea)15(tment infl)35(uence subjec)-15.9(t)-32(i)-16(ve pel)30(v)-16(ic-)]TJ 0.342 Tw T* [(fl)30(o)-16(or )0.5(r)-24(el)-15.9(a)15(ted qual)-30.9(i)-24(t)-10(y )0.5(of)]TJ /Span<>> BDC ( )Tj EMC 10.698 0 Td [(l)-31(ife? )]TJ /T1_1 1 Tf 2.351 0 Td [(Eur )0.5(J )0.5(Obstet )0.5(Gynecol )0.5(R)21(ep)46(rod )0.5(Biol)]TJ /T1_0 1 Tf 0 Tw (. )Tj 0.023 Tw -13.049 -1.25 Td [(2021;259:161\226166. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw [(10.1016/j.ejo)-16(gr)-23.9(b.2021.02.018)]TJ 0 0 0 1 k /GS1 gs 0.108 Tw T* (49.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Insights Int)17(o Incont)-32(inence and t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(P)30(el)30.1(v)-16(ic Fl)30(o)-16(or. Edi)-24(t)17(or)-10(s: F)10(ul)35(y)22(a )]TJ 0.023 Tw -1.796 -1.25 Td [(D\366kmec)-24(i, Diaa)]TJ /Span<>> BDC ( )Tj EMC (EE. )Tj /T1_1 1 Tf 0 Tw (Rizk)Tj /T1_0 1 Tf 0.023 Tw [(: 2022. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1007/978-3-030-94174-1)Tj 0 0 0 1 k /GS1 gs -0.047 Tw T* (50.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(R)11(o)-16(ger)-10(s)]TJ /Span<>> BDC ( )Tj EMC [(RG, Coa)15(tes)]TJ /Span<>> BDC ( )Tj EMC [(KW, K)-16(ammer)-24(er-Doak)]TJ /Span<>> BDC ( )Tj EMC [(D, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC (al. A)Tj /Span<>> BDC ( )Tj EMC [(shor)-22(t for)-16(m of)]TJ /Span<>> BDC ( )Tj EMC [(t)-13(he )]TJ 0.23 Tw -1.796 -1.25 Td [(P)30(el)30(v)-15.9(ic Or)-32(gan P)35(r)-32(ol)-16(apse/U)15.1(r)-37(inar)-24(y Incont)-32(inence Se)-18(xual Q)-16(uest)-32(ionnair)-23.9(e )]TJ 0 Tw T* (\(PISQ-12\). )Tj /T1_1 1 Tf 0.133 Tw 4.658 0 Td [(Int U)21.9(rogynecol J P)15(elvic Floor Dysfunct.)]TJ /T1_0 1 Tf ( 2003;14\(3\):164\226)Tj 0.023 Tw -4.658 -1.25 Td [(168; discussion 168. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1007/s00192-003-1063-2)Tj 0 0 0 1 k /GS1 gs -0.05 Tw T* (51.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(W)16(u)]TJ /Span<>> BDC ( )Tj EMC [(JM, Ma)15(t)-29.9(t)-13(hews)]TJ /Span<>> BDC ( )Tj EMC [(C)20(A, Conover)]TJ /Span<>> BDC ( )Tj EMC [(MM, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. L)-32(ife)-12(t)-32(ime r)-37(isk of)]TJ /Span<>> BDC ( )Tj EMC [(str)-23.9(ess ur)-37(i)]TJ 0 Tw (-)Tj 0.079 Tw -1.796 -1.25 Td [(nar)-24(y incont)-32(inence or pel)30(v)-16(ic or)-32(gan p)25(r)-32(ol)-15.9(apse sur)-32(ger)-24(y. )]TJ /T1_1 1 Tf (Obstet Gynecol)Tj /T1_0 1 Tf 0 Tw (. )Tj 0.023 Tw T* [(2014;123\(6\):1201\2261206. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw [(10.1097/A)15(OG.0000000000000286)]TJ 0 0 0 1 k /GS1 gs 0.255 Tw T* (52.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (\212\031\002\017\027\f\022\026\016)Tj /Span<>> BDC ( )Tj EMC (\213.\212., \207\026\002\017\004\036\r\026)Tj /Span<>> BDC ( )Tj EMC (\236.\202., \025\024\035\036\f\027\017\022\024\r\026)Tj /Span<>> BDC ( )Tj EMC (\224.\203., \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. )Tj 0.264 Tw -1.796 -1.25 Td (\224\036\022\f\031\026\035\034\027\026\016 \235\031\027\022\006\017\016 \ \023\026\006\017\036\027\021\024\022 \f)Tj /Span<>> BDC ( )Tj EMC (\030\026\027\027\017\n\017 \235\024\030\n\026\n\017 \023\030\024\035\026\ \023\f\026 )Tj 0.349 Tw T* (\021\026\024\r\t\b \024\030\020\026\027\024\r. )Tj /T1_1 1 Tf (\016\024\035\020\022\021 \213\034\024\024\022\004\024\021\034\013\034 \023\ \020\022\036\016\033\024\022\035\016\035\037 \b\033\023\201\025\032 )Tj 0.341 Tw T* (\020\037\033\034\b\034\036. \207\016\033\022\030: \214\016\b\022\007\022\ \020\037.)Tj /T1_0 1 Tf [( 2016;\(2\):76\22681. / Dubinsk)-17(a)15(y)22(a)]TJ /Span<>> BDC ( )Tj EMC (E.D., )Tj 0.114 Tw T* [(Babichev)-15(a)]TJ /Span<>> BDC ( )Tj EMC [(I.A., K)25(olesnikov)-15(a)]TJ /Span<>> BDC ( )Tj EMC [(S.N., e)-11.9(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Se)-18(xual func)-16(t)-32(ion in p)32.1(a)14.9(t)-31.9(ients )]TJ 0.035 Tw T* [(wi)-24(t)-13(h ear)-30(l)35.1(y for)-15.9(ms of)]TJ /Span<>> BDC ( )Tj EMC [(pel)30.1(v)-16(ic or)-32(gan p)25(r)-32(ol)-16(apse. )]TJ /T1_1 1 Tf [(R)27(UDN Jour)-13.9(nal of)]TJ /Span<>> BDC ( )Tj EMC (Medicine.)Tj /T1_0 1 Tf 0 Tw ( )Tj 0.023 Tw T* (2016;\(2\):76\22681. \(In Russ.\).)Tj 0.015 Tc 0.545 Tw T* (53.)Tj /Span<>> BDC ( )Tj EMC 1.856 0 Td (\216\017\021\026\030\034\016\027)Tj /Span<>> BDC ( )Tj EMC (\202.\206., \206\024\035\024\r\017\027\026)Tj /Span<>> BDC ( )Tj EMC (\202.\202., \025\024\r\026\035\036\r)Tj /Span<>> BDC ( )Tj EMC (\224.\202., \017)Tj /Span<>> BDC ( )Tj EMC [(\f\024\026\r\021.)15( )]TJ 0.01 Tc 0.367 Tw -1.856 -1.25 Td (\225\235\235\036\022\021\017\r\027\024\f\021\034 \017)Tj /Span<>> BDC ( )Tj EMC (\002\036\024\023\026\f\027\024\f\021\034 \035\026\023\026\030\024\f\022\ \024\023\017\004\036\f\022\024\005 \r\036\027\021\030\026\035\034)Tj 0 Tc 0 Tw (-)Tj 0.189 Tw T* (\027\024\005 \030\036\022\021\024\023\036\022\f\017\017 \f\036\021\004\026\ \021\t\n \017\n\023\035\026\027\021\024\n \(\f\017\f\021\036\n\026\021\017\ \004\036\f\022\017\005 \024\002\024\030\). )Tj /T1_1 1 Tf 0 Tw T* (\r\034\027\034\f\033\034\021\035\034\027\034\013\022\030.)Tj /T1_0 1 Tf -0.012 Tw [( 2022;21\(2\):122\226131. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.33878/2073-7556-)Tj T* (2022-21-2-122-131)Tj 0 0 0 1 k /GS1 gs 0.236 Tw [( / Khi)-24(t)15(ar)-23.9(y)22(an)]TJ /Span<>> BDC ( )Tj EMC [(A.G., Gol)30(ov)-16(ina)]TJ /Span<>> BDC ( )Tj EMC [(A.A., K)25(ov)-15(alev)]TJ /Span<>> BDC ( )Tj EMC (S.A., )Tj 0.098 Tw T* [(e)-12(t)]TJ /Span<>> BDC ( )Tj EMC 1.162 0 Td [(al. )0.5(Ef)-56(f)-28(ic)-24(iency and )0.5(safe)-12(t)-10(y )0.5(of)]TJ /Span<>> BDC ( )Tj EMC [(l)-16(ap)32(ar)-32(oscopic )0.5(ventr)-33(al )0.5(mesh r)-23.9(ec)-16(t)17(ope)-18(xy )]TJ 0.32 Tw -1.162 -1.25 Td [(\(a sy)-13(stema)15(t)-32(ic r)-23.9(ev)-16(iew\). )]TJ /T1_1 1 Tf 0 Tw [(K)18(olop)46(roktologia)]TJ /T1_0 1 Tf 0.32 Tw (. 2022;21\(2\):122\226131. \(In )Tj 0.023 Tw T* [(Russ.\). d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.33878/2073-7556-2022-21-2-122-131)Tj 0 0 0 1 k /GS1 gs 0.301 Tw T* (54.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(W)22(eber)]TJ /Span<>> BDC ( )Tj EMC [(AM, W)12.1(al)56(ter)-10(s)]TJ /Span<>> BDC ( )Tj EMC [(MD, P)-23.9(iedmonte)]TJ /Span<>> BDC ( )Tj EMC [(MR. Se)-18(xual func)-16(t)-32(ion and )]TJ 0.332 Tw -1.796 -1.25 Td [(v)-15(a)-17(ginal )0.6(ana)15(t)17(omy )0.6(in )0.5(w)-14(omen )0.6(befor)-24(e )0.6(and )0.5(af)-28(ter )0.6(sur)-32(ger)-23.9(y )0.5(for )0.6(pel)30(v)-16(ic )]TJ 0.313 Tw T* [(or)-32(gan )0.5(p)25(r)-32(ol)-16(apse )0.5(and )0.5(ur)-37(inar)-23.9(y )0.5(incont)-32(inence. )]TJ /T1_1 1 Tf 18.495 0 Td [(Am )0.5(J )0.5(Obstet )0.5(Gynecol)]TJ /T1_0 1 Tf 0 Tw (. )Tj 0.023 Tw 10.56 81.25 Td [(2000;182\(6\):1610\2261615. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1067/mob.2000.107436)Tj 0 0 0 1 k /GS1 gs 0.325 Tw T* (55.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(T)60(so)]TJ /Span<>> BDC ( )Tj EMC [(C, )0.5(L)35(ee)]TJ /Span<>> BDC ( )Tj EMC [(W, )0.5(A)10(ust)-32(in-K)25(e)-12(tch)]TJ /Span<>> BDC ( )Tj EMC 12.227 0 Td [(T, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC 2.592 0 Td [(al. )0.5(N)-14(onsur)-32(gical )0.5(T)49.9(r)-23.9(ea)15(tment )]TJ 0.065 Tw -16.615 -1.25 Td [(Opt)-32(ions for W)20(omen W)-16(i)-24(t)-12.9(h P)30(el)30(v)-16(ic Or)-32(gan P)35(r)-32(ol)-16(apse. )]TJ /T1_1 1 Tf [(N)21(ursing for W)29(omen\237s )]TJ 0 Tw T* (Health)Tj /T1_0 1 Tf 0.023 Tw [( 2018;22\(3\):228\226239. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1016/J.NWH.2018.03.007)Tj 0 0 0 1 k /GS1 gs 0.054 Tw T* (56.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(V)25(an den Br)-31.9(oeck)]TJ /Span<>> BDC ( )Tj EMC (S, Nullens)Tj /Span<>> BDC ( )Tj EMC [(S, Ja)-17(cquemyn)]TJ /Span<>> BDC ( )Tj EMC [(Y, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. P)10(oster)-37(ior com)]TJ 0 Tw (-)Tj 0.05 Tw -1.796 -1.25 Td [(p)32(ar)-22(tment p)25(r)-32(ol)-15.9(apse and per)-36.9(ineal descent: sy)-13(stema)15.1(t)-32(ic r)-23.9(ev)-16(iew of)]TJ /Span<>> BDC ( )Tj EMC [(av)-15(ail)]TJ 0 Tw (-)Tj 0.285 Tw T* [(able )0.5(suppor)-21.9(t )0.5(dev)-16(ices. )]TJ /T1_1 1 Tf 9.636 0 Td [(Int )0.5(U)22(rogynecol)]TJ /Span<>> BDC ( )Tj EMC 6.551 0 Td (J)Tj /T1_0 1 Tf [(. )0.5(2023;34\(11\):2629\2262645. )]TJ 0 Tw -16.187 -1.25 Td [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1007/s00192-023-05508-2)Tj 0 0 0 1 k /GS1 gs -0.014 Tw -1.847 -1.25 Td (57.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(P)10(o)-14(wer)-9.9(s)]TJ /Span<>> BDC ( )Tj EMC [(SA, Bur)-30(leson)]TJ /Span<>> BDC ( )Tj EMC (LK, Hannan)Tj /Span<>> BDC ( )Tj EMC [(JL. Mana)-16.9(ging female pel)30(v)-16(ic fl)30(o)-16(or )]TJ 0.181 Tw -1.796 -1.25 Td [(disor)-23.9(der)-10(s: a)]TJ /Span<>> BDC ( )Tj EMC [(medical dev)-16(ice r)-24(ev)-16(iew and app)25(r)-33(aisal. )]TJ /T1_1 1 Tf [(Inter)-34(face F)12(ocus)]TJ /T1_0 1 Tf 0 Tw (. )Tj 0.023 Tw T* [(2019;9\(4\):20190014. d)-15.9(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw [(10.1098/r)-10(sfs.2019.0014)]TJ 0 0 0 1 k /GS1 gs 0.148 Tw T* (58.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Hall)Tj /Span<>> BDC ( )Tj EMC [(GM, S)-16(hanmugan)]TJ /Span<>> BDC ( )Tj EMC [(S, N)-14(obel)]TJ /Span<>> BDC ( )Tj EMC [(T, e)-11.9(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Sym)10(pt)17(oma)15(t)-32(ic r)-23.9(ec)-16(t)17(o)-16(cele: )]TJ 0.156 Tw -1.796 -1.25 Td [(wha)15(t ar)-23.9(e t)-12.9(he)]TJ /Span<>> BDC ( )Tj EMC [(indica)15(t)-32(ions for r)-23.9(ep)32(air? )]TJ /T1_1 1 Tf (Am J Surg)Tj /T1_0 1 Tf (. 2014;207\(3\):375\226)Tj 0.023 Tw T* [(379; discussion 378-379. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw [(10.1016/j.amjsur)-32(g.2013.12.002)]TJ 0 0 0 1 k /GS1 gs 0.168 Tw T* (59.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Bar)-24(bal)-15.9(a)15(t)]TJ /Span<>> BDC ( )Tj EMC [(Y, T)60(unuguntl)-15.9(a)]TJ /Span<>> BDC ( )Tj EMC [(HS. Sur)-32(ger)-24(y for pel)30(v)-16(ic or)-32(gan p)25(r)-32(ol)-15.9(apse: )]TJ 0.012 Tc 0.443 Tw -1.796 -1.25 Td (a)Tj /Span<>> BDC ( )Tj EMC [(hist)17(or)-36.9(ical per)-10(spec)-16(t)-31.9(i)-16(ve. )]TJ /T1_1 1 Tf [(Cur)-16(r U)22(rol R)21(ep)]TJ /T1_0 1 Tf [(. 2012;13\(3\):256\226261.)12( )]TJ 0 Tc 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1007/s11934-012-0249-x)Tj 0 0 0 1 k /GS1 gs 0.088 Tw -1.847 -1.25 Td (60.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (\203\026\031\n\024\r)Tj /Span<>> BDC ( )Tj EMC (\202.\200., \025\031\035\017\022\024\r\f\022\017\005)Tj /Span<>> BDC ( )Tj EMC (\200.\205., \210\035\036\005\027\017\022)Tj /Span<>> BDC ( )Tj EMC (\203.\200. \210\006\036\027\022\026 \030\036\031\035\034)Tj 0 Tw (-)Tj 0.313 Tw -1.796 -1.25 Td [(\021\026\021\024\r )0.5(\b\017\030\031\030\020\017\004\036\f\022\024\020\024 )0.5(\035\036\004\036\027\017\016 )0.5(\030\036\022\021\024\006\036\035\036 )0.6(\027\026)]TJ /Span<>> BDC ( )Tj EMC 20.009 0 Td [(\235\024\027\036 )0.5(\022\024\n\002\017\027\017\030\024)]TJ 0 Tw (-)Tj 0.086 Tw -20.009 -1.25 Td (\r\026\027\027\024\005 \023\026\021\024\035\024\020\017\017 \021\026\024\ \r\024\020\024 \007\027\026 \017)Tj /Span<>> BDC ( )Tj EMC (\r \026\r\017\f\017\n\024\f\021\017 \024\021 \024\023\036\030\026\021\017\ \r\027\024\020\024 )Tj 0 Tw T* (\007\024\f\021\031\023\026. )Tj /T1_1 1 Tf 0.289 Tw 4.039 0 Td (\016\024\035\020\022\021 \220\021\024\f\016\033\022\006\016\020\035\037\ \027\003\020\034\004 \022)Tj /Span<>> BDC ( )Tj EMC (\021\027\022\020\022\005\016\024\021\034\004 \002\022\033\023\033\013\022\ \022.)Tj /T1_0 1 Tf 0 Tw ( )Tj 0.247 Tw -4.039 -1.25 Td (2009;2\(2\):129\226136. / Naumov)Tj /Span<>> BDC ( )Tj EMC [(A.V., K)25(ul)-31(ikovsk)-15.9(ij)]TJ /Span<>> BDC ( )Tj EMC (V.F., Olejnik)Tj /Span<>> BDC ( )Tj EMC (N.V. )Tj 0.003 Tc 0.35 Tw T* [(O)-16(cenk)-17(a )0.5(r)-24(ezul\246t)15(a)14.9(t)17(ov )0.5(hir)-22.1(ur)-32(gichesko)-16.1(go )0.5(lechenija )0.5(r)-24(ek)-24(t)17(o)-16.1(cele na )0.5(fone)3( )]TJ 0 Tc 0.179 Tw T* [(kombinir)-32(ov)-14.9(annoj p)32(a)15(t)17(ol)30(o)-16(gi)-15.9(i t)15(a)-24(zovo)-15.9(go dna i v zav)-15.9(isimost)-32(i o)17(t oper)-33(a)]TJ 0 Tw (-)Tj 0.245 Tw T* [(t)-32(i)-16(vno)-15.9(go d)-16(ostup)32(a. )]TJ /T1_1 1 Tf [(V)33(estnik jek)-23(sper)-36.9(imental\237noj i klinichesk)13.1(oj hirurgii)]TJ /T1_0 1 Tf 0 Tw (. )Tj 0.023 Tw T* (2009;2\(2\):129\226136. \(In Russ.\).)Tj 0.009 Tc 0.352 Tw T* (61.)Tj /Span<>> BDC ( )Tj EMC 1.833 0 Td [(M)-24.3(o)-14.4(w)-12.3(a)14.6(t)]TJ /Span<>> BDC ( )Tj EMC (A, Maher)Tj /Span<>> BDC ( )Tj EMC (D, Baessler)Tj /Span<>> BDC ( )Tj EMC [(K, e)-12.4(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Sur)-32.4(ger)-24.3(y for w)-14.4(omen)9( )]TJ 0 Tc 0.156 Tw -1.833 -1.25 Td [(wi)-24(t)-12.9(h poster)-36.9(ior com)10(p)32(ar)-22(tment p)25(r)-32(ol)-15.9(apse. )]TJ /T1_1 1 Tf [(Cochrane Database Syst R)21(ev)]TJ /T1_0 1 Tf 0 Tw (. )Tj 0.023 Tw T* [(20185;3\(3\):CD012975. d)-15.9(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1002/14651858.CD012975)Tj 0 0 0 1 k /GS1 gs -0.001 Tw T* (62.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Doumouchtsis)Tj /Span<>> BDC ( )Tj EMC [(SK, R)-10(aheem)]TJ /Span<>> BDC ( )Tj EMC [(AA, Milhem Hadd)42(ad)]TJ /Span<>> BDC ( )Tj EMC [(J, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC (al. An)Tj /Span<>> BDC ( )Tj EMC [(upd)42(a)15(te )]TJ 0.05 Tw -1.796 -1.25 Td (of)Tj /Span<>> BDC ( )Tj EMC (a)Tj /Span<>> BDC ( )Tj EMC [(for)-16(mer FIGO W)20.1(or)-24(k)-16(ing G)20(r)-32(oup R)13(epor)-22(t on Mana)-17(gement of)]TJ /Span<>> BDC ( )Tj EMC [(P)10(oster)-37(ior )]TJ 0.012 Tw T* [(Com)10(p)32(ar)-22(tment P)35(r)-32(ol)-16(apse. )]TJ /T1_1 1 Tf (Int J Gynaecol Obstet. )Tj /T1_0 1 Tf 0 Tw (2020;148\(2\):135\226144. )Tj T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1002/ijgo.13006)Tj 0 0 0 1 k /GS1 gs 0.129 Tw -1.847 -1.25 Td (63.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(T)40(asev)]TJ /Span<>> BDC ( )Tj EMC [(V, T)45(od)-16(or)-32(ov)]TJ /Span<>> BDC ( )Tj EMC [(R, T)40(asev)-15(a)]TJ /Span<>> BDC ( )Tj EMC [(A. 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na)15(t)-32(i)-15.9(ve t)-32(issue r)-24(ep)32(air for pel)30(v)-16(ic or)-32(gan p)25(r)-32(ol)-16(apse. )]TJ /T1_2 1 Tf 0 Tw [(Inter)-13.9(national )]TJ 0.083 Tw 0 -1.25 TD [(U)22(rogynecology Jour)-13.9(nal and P)15(elvic Floor Dysfunction.)]TJ /T1_1 1 Tf ( 2014;25\(1\):81\226)Tj 0.023 Tw T* [(89. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1007/s00192-013-2166-z)Tj 0 0 0 1 k /GS1 gs 0.297 Tw T* (10.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Bar)-24(ber)]TJ /Span<>> BDC ( )Tj EMC (MD, Maher)Tj /Span<>> BDC ( )Tj EMC [(C. Epidemiol)30.1(o)-16(g)16(y and outcome assess)26(ment )]TJ 0.196 Tw -1.796 -1.25 Td (of)Tj /Span<>> BDC ( )Tj EMC [(pel)30(v)-15.9(ic or)-32(gan p)25(r)-32(ol)-16(apse. )]TJ /T1_2 1 Tf [(Inter)-13.9(national U)22(rogynecology )0.5(Jour)-13.9(nal and )]TJ 0.001 Tc 0.349 Tw T* [(P)15.5(e)0.5(l)0.5(v)0.5(i)0.6(c)0.5( F)0.5(l)0.5(o)0.5(o)0.5(r)0.6( D)0.5(y)0.5(s)0.5(f)0.6(u)0.5(n)0.5(c)0.5(t)0.5(i)0.5(o)0.5(n)]TJ /T1_1 1 Tf 10.047 0 Td [(.)0.5( 2)0.6(0)0.5(13)0.6(;)0.5(2)0.5(4)0.5(\()0.5(1)0.5(1)0.5(\))0.5(:)0.5(1)0.5(7)0.5(8)0.5(3)0.5(\226)0.5(1)0.5(7)0.5(9)0.5(0)0.5(.)0.6( d)-15.5(o)0.5(i)0.5(:)]TJ /Span<>> BDC 13.265 0 Td ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs -0.001 Tw [(1)0.5(0)0.5(.)0.6(10)0.6(0)0.5(7)0.5(/)]TJ 0 Tc 0 Tw -23.312 -1.25 Td (s00192-013-2169-9)Tj 0 0 0 1 k /GS1 gs 0.222 Tw T* (11.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(v)-15(an den Br)-32(oeck)]TJ /Span<>> BDC ( )Tj EMC [(S, Ja)-17(cquemyn)]TJ /Span<>> BDC ( )Tj EMC (Y, Hubens)Tj /Span<>> BDC ( )Tj EMC [(G, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. R)13(ec)-16(t)17(o)-15.9(cele: )]TJ 0.073 Tw -1.796 -1.25 Td [(v)-16(ic)-16(t)-31.9(im of)]TJ /Span<>> BDC ( )Tj EMC [(av)-15(ail)-15.9(abil)-31(i)-24(t)-9.9(y bias? R)13(esul)56(ts of)]TJ /Span<>> BDC ( )Tj EMC (a)Tj /Span<>> BDC ( )Tj EMC [(Bel)16(gian sur)-32(ve)-11(y of)]TJ /Span<>> BDC ( )Tj EMC [(col)30(or)-24(ec)-15.9(t)15(al )]TJ 0.259 Tw T* [(and g)16(ynecol)30(o)-16(gical sur)-32(geons. )]TJ /T1_2 1 Tf [(Inter)-13.9(national U)22(rogynecology Jour)-13.9(nal.)]TJ /T1_1 1 Tf 0 Tw ( )Tj 0.023 Tw T* [(2022;33\(12\):3505\2263517. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1007/S00192-022-05118-4)Tj 0 0 0 1 k /GS1 gs -0.014 Tw T* (12.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(K)-16(a)15(yembe)]TJ /Span<>> BDC ( )Tj EMC [(A)15(T, Muel)-15.9(a)]TJ /Span<>> BDC ( )Tj EMC [(AM, Balek)-16.9(a)]TJ /Span<>> BDC ( )Tj EMC [(AM, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Geni)-23.9(t)15(al p)25(r)-32(ol)-16(apse: epide)]TJ 0 Tw (-)Tj -0.001 Tw -1.796 -1.25 Td [(miol)30(o)-16(g)16(y, cl)-31(inic and t)-13(her)-33(apeut)-31.9(ic a)15(t Saint Joseph Hospi)-24(t)15(al of)]TJ /Span<>> BDC ( )Tj EMC (Kinshasa. )Tj /T1_2 1 Tf 0.328 Tw T* (The)Tj /Span<>> BDC ( )Tj EMC [(P)17.9(an Afr)-37(ican Medical Jour)-14(nal)]TJ /T1_1 1 Tf [(. 2020;37:1\22610. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.11604/)Tj T* [(P)25(AMJ.2020.37.196.21818)]TJ 0 0 0 1 k /GS1 gs 0.2 Tw T* (13.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Hand)42(a)]TJ /Span<>> BDC ( )Tj EMC [(VL, Bl)30(omquist)]TJ /Span<>> BDC ( )Tj EMC [(JL, R)10.9(oem)]TJ /Span<>> BDC ( )Tj EMC [(J, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. P)30.1(el)30(v)-16(ic Fl)30(o)-16(or Disor)-24(der)-9.9(s )]TJ 0.213 Tw -1.796 -1.25 Td [(af)-28(ter Obste)-11.9(tr)-37(ic A)15(vulsion of)]TJ /Span<>> BDC ( )Tj EMC [(t)-13(he L)35(ev)-15(a)15(t)17(or Ani Muscle. )]TJ /T1_2 1 Tf [(F)11(emale P)15(elvic )]TJ -0.016 Tw T* [(Medicine and R)21(econstructiv)13.1(e Surg)12(er)-43(y.)]TJ /T1_1 1 Tf [( 2019;25\(1\):8\22614. d)-15.9(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1097/)Tj T* (SPV.0000000000000644)Tj 0 0 0 1 k /GS1 gs 0.233 Tw T* (14.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(A)15(y)-16(t)15(an)]TJ /Span<>> BDC ( )Tj EMC [(H, Er)-22(tun\347)]TJ /Span<>> BDC ( )Tj EMC [(D, T)45(ok)]TJ /Span<>> BDC ( )Tj EMC [(EC, e)-11.9(t)]TJ /Span<>> BDC ( )Tj EMC [(al. P)35(r)-24(ev)-15(alence of)]TJ /Span<>> BDC ( )Tj EMC [(pel)30(v)-16(ic or)-32(gan )]TJ 0.101 Tw -1.796 -1.25 Td [(p)25(r)-32(ol)-16(apse and r)-24(el)-15.9(a)15(ted f)16.1(a)-17(c)-16(t)17(or)-10(s in a)]TJ /Span<>> BDC ( )Tj EMC [(gener)-33(al female popul)-16(a)15(t)-31.9(ion. )]TJ /T1_2 1 Tf [(T)57(urk J )]TJ 0.023 Tw T* (Obstet Gynecol. )Tj /T1_1 1 Tf [(2014;11\(3\):176\226180. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.4274/tjod.90582)Tj 0 0 0 1 k /GS1 gs 0.062 Tw T* (15.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Milsom)Tj /Span<>> BDC ( )Tj EMC [(I, G)24(yha)-17(gen)]TJ /Span<>> BDC ( )Tj EMC [(M. Br)-23.9(eak)-16(ing news in t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(p)25(r)-24(edic)-16(t)-32(ion of)]TJ /Span<>> BDC ( )Tj EMC [(pel)30(v)-16(ic )]TJ 0.086 Tw -1.796 -1.25 Td [(fl)30(o)-16(or disor)-24(der)-9.9(s. )]TJ /T1_2 1 Tf [(Best Pract R)21(es Clin Obstet Gynaecol.)]TJ /T1_1 1 Tf ( 2019;54:41\22648. )Tj 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td [(10.1016/j.bpobg)16(yn.2018.05.004)]TJ 0 0 0 1 k /GS1 gs 0.177 Tw -1.847 -1.25 Td (16.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(G)24(yha)-17(gen)]TJ /Span<>> BDC ( )Tj EMC [(M, Bull)-15.9(ar)-24(bo)]TJ /Span<>> BDC ( )Tj EMC (M, Nielsen)Tj /Span<>> BDC ( )Tj EMC [(TF, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. P)35(r)-24(ev)-14.9(alence and r)-37(isk )]TJ 0.012 Tw -1.796 -1.25 Td [(f)16(a)-17(c)-16(t)17(or)-9.9(s for pel)30(v)-15.9(ic or)-32(gan p)25(r)-32(ol)-15.9(apse 20 year)-9.9(s af)-28(ter childbir)-22(t)-13(h: a)]TJ /Span<>> BDC ( )Tj EMC [(na)15(t)-32(ional )]TJ -0.03 Tw T* [(cohor)-22(t stud)17(y in single)-12(t)17(on p)25(r)-36.9(imip)32(ar)-33(ae af)-28(ter v)-15(a)-17(ginal or caesar)-23.9(ean del)-30.9(i)-16(v)]TJ 0 Tw 27.286 0 Td (-)Tj -27.286 -1.25 Td [(er)-24(y. )]TJ /T1_2 1 Tf 1.803 0 Td [(BJ)30(OG)]TJ /T1_1 1 Tf 0.023 Tw [(. 2013;120\(2\):152\226160. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1111/1471-0528.12020)Tj 0 0 0 1 k /GS1 gs 0.132 Tw -1.803 -1.25 Td (17.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Dur)-15(nea)]TJ /Span<>> BDC ( )Tj EMC [(CM, O\246R)13(eill)35(y)]TJ /Span<>> BDC ( )Tj EMC (BA, Khashan)Tj /Span<>> BDC ( )Tj EMC [(A)35(S, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. S)15(t)15.1(a)15(tus of)]TJ /Span<>> BDC ( )Tj EMC [(t)-12.9(he pel)30(v)-16(ic )]TJ 0.006 Tc 0.349 Tw -1.796 -1.25 Td [(fl)30.1(o)-15.8(or in young p)25.2(r)-36.8(imip)32.2(ar)-31.8(ous w)-13.9(omen. )]TJ /T1_2 1 Tf (Ultrasound Obstet Gynecol)Tj /T1_1 1 Tf 0 Tc 0 Tw (. )Tj 0.023 Tw T* [(2015;46\(3\):356\226362. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw [(10.1002/uo)-16(g.14711)]TJ 0 0 0 1 k /GS1 gs 0.264 Tw T* (18.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(R)11(odr\355guez-A)-13.9(bar)-32(ca)]TJ /Span<>> BDC ( )Tj EMC [(MA, Her)-15(n\341ndez-G)20.1(r)-37(imald)-16(o)]TJ /Span<>> BDC ( )Tj EMC [(EG, De l)-16(a F)10(uente-)]TJ -0.021 Tw -1.796 -1.25 Td [(V)-15(ill)-16(ar)-23.9(r)-24(eal)]TJ /Span<>> BDC ( )Tj EMC [(D, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. G)24(ynecol)30.1(o)-16(gical infl)35.1(uenc)-24(ing f)16(a)-17(c)-15.9(t)17(or)-10(s on t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(r)-24(ec)-16(t)17(ov)-15(a)-17(gi)]TJ 0 Tw (-)Tj 0.079 Tw T* [(nal septum\246s mor)-24(phol)30(o)-16(g)16(y. )]TJ /T1_2 1 Tf [(Int U)22(rogynecol)]TJ /Span<>> BDC ( )Tj EMC (J)Tj /T1_1 1 Tf (. 2021;32\(6\):1427\2261432. )Tj 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1007/s00192-020-04376-4)Tj 0 0 0 1 k /GS1 gs 0.119 Tw -1.847 -1.25 Td (19.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Sun)Tj /Span<>> BDC ( )Tj EMC 1.851 0 Td [(MJ, )0.6(Cheng)]TJ /Span<>> BDC ( )Tj EMC 4.478 0 Td [(YS, )0.6(Sun)]TJ /Span<>> BDC ( )Tj EMC 3.332 0 Td [(R, )0.6(e)-12(t)]TJ /Span<>> BDC ( )Tj EMC 2.246 0 Td [(al. )0.6(Changes )0.5(in )0.6(mi)-24(t)17(o)-16(chondr)-36.9(ial )0.5(DN)13(A )]TJ 0.124 Tw -13.703 -1.25 Td [(copy number and e)-18(xtr)-33(a)-17(cell)35(ul)-16(ar ma)15(tr)-36.9(ix \(ECM\) p)25(r)-32(o)17.1(teins in t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(uter)-32(o)]TJ 0 Tw (-)Tj 0.188 Tw T* [(sa)-17(cr)-33(al l)-30.9(igaments of)]TJ /Span<>> BDC ( )Tj EMC [(p)25(r)-24(emenop)32(ausal w)-14(omen wi)-23.9(t)-13(h pel)30(v)-16(ic or)-32(gan p)25(r)-32(o)]TJ 0 Tw (-)Tj T* [(l)-16(apse. )]TJ /T1_2 1 Tf 0.225 Tw 2.85 0 Td [(T)54(aiw)13(an J Obstet Gynecol)]TJ /T1_1 1 Tf [(. 2016;55\(1\):9\22615. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1016/j.)Tj -2.85 -1.25 Td [(tjo)-16(g.2014.04.032)]TJ 0 0 0 1 k /GS1 gs 0.131 Tw T* (20.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(K)25(udish)]TJ /Span<>> BDC ( )Tj EMC (BI, Iglesia)Tj /Span<>> BDC ( )Tj EMC [(CB, S)-16(okol)]TJ /Span<>> BDC ( )Tj EMC [(RJ, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Ef)-56(fec)-16(t of)]TJ /Span<>> BDC ( )Tj EMC (weight change )Tj 0.011 Tc 0.417 Tw -1.796 -1.25 Td [(on na)14.7(tur)-33.2(al hist)16.8(or)-24.2(y of)]TJ /Span<>> BDC ( )Tj EMC [(pel)29.7(v)-16.2(ic or)-32.2(gan p)24.8(r)-32.3(ol)-16.2(apse. )]TJ /T1_2 1 Tf (Obstet Gynecol.)Tj /T1_1 1 Tf 0 Tc 0 Tw 27.638 0 Td ( )Tj 0.023 Tw -27.638 -1.25 Td [(2009;113\(1\):81\22688. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw [(10.1097/A)15(OG.0b013e318190a0dd)]TJ 0 0 0 1 k /GS1 gs 0.005 Tc 0.35 Tw T* (21.)Tj /Span<>> BDC ( )Tj EMC 1.816 0 Td [(M)16(yer)-9.9(s)]TJ /Span<>> BDC ( )Tj EMC 2.889 0 Td [(DL, )0.6(Sung)]TJ /Span<>> BDC ( )Tj EMC 4.395 0 Td [(VW, )0.6(R)-24(ichter)]TJ /Span<>> BDC ( )Tj EMC 5.534 0 Td [(HE, )0.6(e)-12(t)]TJ /Span<>> BDC ( )Tj EMC 3.31 0 Td [(al. )0.6(P)35(r)-32(ol)-15.9(apse )0.5(sym)10(pt)17(oms)5( )]TJ 0 Tc 0.335 Tw -17.944 -1.25 Td [(in over)-38(weight and obese w)-13.9(omen befor)-24(e and af)-28(ter weight l)30(oss. )]TJ /T1_2 1 Tf 0.139 Tw T* [(F)11(emale )0.5(P)15(elvic Med )0.5(R)21(econstr )0.5(Surg)]TJ /T1_1 1 Tf [(. 2012;18\(1\):55\22659. )0.5(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1097/)Tj T* (SPV.0b013e31824171f9)Tj 0 0 0 1 k /GS1 gs 0.025 Tw T* (22.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Ol)-31(i)-16(veir)-32.9(a)]TJ /Span<>> BDC ( )Tj EMC [(D)20(A, )0.5(P)40(ar)-24(ente)]TJ /Span<>> BDC ( )Tj EMC [(MPL, )0.5(Cal)30(vo)]TJ /Span<>> BDC ( )Tj EMC 12.693 0 Td [(B, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. T)47.1(he)]TJ /Span<>> BDC ( )Tj EMC [(mana)-17(gement )0.5(of)]TJ /Span<>> BDC ( )Tj EMC (epi)Tj 0 Tw (-)Tj 0.254 Tw -14.489 -1.25 Td [(sio)17(t)17(omy technique and i)-24(ts ef)-56(fec)-16(t on pel)30(v)-16(ic fl)30(o)-16(or muscles dur)-36.9(ing )]TJ 0.209 Tw T* (a)Tj /Span<>> BDC ( )Tj EMC [(malposi)-23.9(t)-32(ion childbir)-21.9(t)-13(h. )]TJ /T1_2 1 Tf [(Com)16.1(put Methods Biomech Biomed Engin)]TJ /T1_1 1 Tf 0 Tw (. )Tj 0.023 Tw T* [(2017;20\(11\):1249\2261259. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1080/10255842.2017.1349762)Tj 0 0 0 1 k /GS1 gs 0.013 Tc 0.465 Tw T* (23.)Tj /Span<>> BDC ( )Tj EMC 1.846 0 Td [(Gher)-9.6(sel)]TJ /Span<>> BDC ( )Tj EMC [(FR, S)-15.6(out)17.4(o)]TJ /Span<>> BDC ( )Tj EMC (RP, Gonzales)Tj /Span<>> BDC ( )Tj EMC [(EWP, e)-11.6(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Assess)26.4(ment)13( )]TJ 0 Tc 0.319 Tw -1.846 -1.25 Td (of)Tj /Span<>> BDC ( )Tj EMC 1.366 0 Td [(Me)-12(t)15(all)30.1(op)25(r)-32(o)17(teinase )0.6(Ma)15(tr)-37(ix )0.6(9 )0.5(\(MMP9\) )0.6(Gene )0.6(P)10(ol)35(ymor)-24(phis)26(ms )0.6(R)-24(isk )]TJ 0.169 Tw -1.366 -1.25 Td [(F)20(a)-17(c)-16(t)17(or)-10(s for P)30(el)30(v)-16(ic Or)-32(gan P)35(r)-32(ol)-16(apse in t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(Br)-32.9(a)-24(zil)-31(ian P)10(opul)-16(a)15(t)-32(ion. )]TJ /T1_2 1 Tf 0 Tw [(R)20.9(ev )]TJ 0.004 Tc 0.35 Tw T* (Bras Ginecol Obstet)Tj /T1_1 1 Tf [(. 2019;41\(3\):164\226169. d)-16.3(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs -0.004 Tw (10.1055/s-0039-)Tj 0 Tc 0 Tw T* (1681112)Tj 0 0 0 1 k /GS1 gs 0.334 Tw T* (24.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Kinman)Tj /Span<>> BDC ( )Tj EMC [(CL, L)35(emieux)]TJ /Span<>> BDC ( )Tj EMC [(C)20(A, A)-25(gr)-33(a)10(w)-11.9(al)]TJ /Span<>> BDC ( )Tj EMC [(A, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. T)47(he)]TJ /Span<>> BDC ( )Tj EMC [(r)-24(el)-15.9(a)15(t)-32(ionship )]TJ 0.205 Tw -1.796 -1.25 Td [(be)-12(t)-32(ween a)-17(ge and pel)30(v)-15.9(ic or)-32(gan p)25(r)-32(ol)-16(apse bo)17(t)-13(her. )]TJ /T1_2 1 Tf [(Int U)22(rogynecol)]TJ /Span<>> BDC ( )Tj EMC (J)Tj /T1_1 1 Tf 0 Tw (. )Tj 0.023 Tw T* [(2017;28\(5\):751\226755. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1007/s00192-016-3175-5)Tj 0 0 0 1 k /GS1 gs 0.214 Tw T* (25.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (\236\035\034\017\027\026)Tj /Span<>> BDC ( )Tj EMC (\236.\222., \212\024\002\030\024\b\024\021\024\r\026)Tj /Span<>> BDC ( )Tj EMC (\222.\225., \222\n\017\027\026)Tj /Span<>> BDC ( )Tj EMC (\224.\200. \206\024\030\n\024\027\026\035\034\027\t\005 )Tj 0.126 Tw -1.796 -1.25 Td (\f\021\026\021\031\f \031)Tj /Span<>> BDC ( )Tj EMC (\032\036\027\013\017\027 \030\036\023\030\024\007\031\022\021\017\r\027\024\ \020\024 \r\024\030\026\f\021\026 \f)Tj /Span<>> BDC ( )Tj EMC (\007\017\f\023\035\026\017\036\005 \f\024\036\007\017)Tj 0 Tw (-)Tj 0.153 Tw T* (\027\017\021\036\035\034\027\024\005 \021\022\026\027\017 \017)Tj /Span<>> BDC ( )Tj EMC (\002\036 \027\036\036. )Tj /T1_2 1 Tf (\016\024\035\020\022\021 \213\034\024\024\022\004\024\021\034\013\034 \023\ \020\022\036\016\033\024\022\035\016\035\037 )Tj 0.2 Tw T* (\b\033\023\201\025\032 \020\037\033\034\b\034\036. \207\016\033\022\030:\ \006\016\b\022\007\022\020\037. 2010)Tj /T1_1 1 Tf (;\(2\):65\22669. / Il\246ina I.J., )Tj 0.188 Tw T* [(Dobr)-32(oho)17(t)17(ov)-15(a Ju.Je., Jumina)]TJ /Span<>> BDC ( )Tj EMC [(S.V. Gor)-15.9(monal\246nyj st)15.1(a)15(tus u zhenshhin )]TJ 0.045 Tw T* [(r)-24(ep)25(r)-32(oduk)-23.9(t)-32(i)-16(vno)-16(go vozr)-33(ast)15.1(a s displ)-16(a)-24(ziej soedini)-23.9(tel\246noj tk)-17(ani i bez nee. )]TJ /T1_2 1 Tf 0.234 Tw 29.055 81.25 Td [(V)33(estnik R)19(ossi)11.1(jsk)13(ogo univ)13(ersiteta druzhby narodov)]TJ /T1_1 1 Tf 0 Tw (. )Tj /T1_2 1 Tf 0.234 Tw 20.793 0 Td [(Ser)-37(i)11(ja: medicina)]TJ /T1_1 1 Tf 0 Tw (. )Tj 0.023 Tw -20.793 -1.25 Td (2010;\(2\):65\22669. \(In Russ.\).)Tj 0.007 Tc 0.349 Tw T* (26.)Tj /Span<>> BDC 1.316 0 Td ( )Tj EMC 0.507 0 Td [(\216\026\027)0.5(\026\007\016)0.5(\027)]TJ /Span<>> BDC ( )Tj EMC [(\204.\214.)0.5(, \212)0.5(\036\n\031\030\026)]TJ /Span<>> BDC 10.197 0 Td ( )Tj EMC [(\230.\202.)0.5( \210\f\024)0.5(\002\036\027\027)0.5(\024\f\021\017)0.5( \f\024)0.5(\036\007\017\027)0.5(\017\021\036\035)0.5(\034\027\024\005)7.1( )]TJ 0 Tc 0.22 Tw -12.019 -1.25 Td (\021\022\026\027\017 \f\r\016\024\004\027\024\020\024 \026\023\023\026\030\ \026\021\026 \n\026\021\022\017 \031)Tj /Span<>> BDC ( )Tj EMC (\032\036\027\013\017\027 \f)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\035\026\023\f\024\n \020\036\027\017)Tj 0 Tw (-)Tj 0.012 Tc -0.012 Tw T* (\021\026\035\017\005. )Tj /T1_2 1 Tf 0.437 Tw 3.403 0 Td (\r\037\031\037\020\024\021\022\004 \006\016\b\022\007\022\020\024\021\022\ \004 \201\023\033\020\037\027. )Tj /T1_1 1 Tf -0.012 Tw [(2015;96\(4\):498\226505.)12( )]TJ 0.014 Tc -0.014 Tw -3.403 -1.25 Td [(d)-15.4(o)0.5(i)0.6(:)]TJ /Span<>> BDC 1.645 0 Td ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0.741 0 Td [(1)0.5(0)0.6(.)0.6(1)0.5(7)0.6(7)0.5(5)0.6(0)0.5(/)0.6(K)0.6(M)0.5(J)0.6(2)0.5(0)0.6(1)0.5(5)0.6(-)0.6(4)0.5(9)0.6(8)]TJ 0 0 0 1 k /GS1 gs 0.013 Tc 0.495 Tw 9.996 0 Td [( / Hanzad)16.5(jan)]TJ /Span<>> BDC ( )Tj EMC [(M.L., Demur)-33.4(a)]TJ /Span<>> BDC ( )Tj EMC [(T.A.)13( )]TJ 0 Tc 0.307 Tw -12.382 -1.25 Td [(Osobennost)-32(i soedini)-24(tel\246noj tk)-17(ani svja)-23.9(zo)-16(chno)-16(go app)32(ar)-32.9(a)15(t)15(a ma)15(tk)-16(i u )]TJ 0.006 Tc 0.349 Tw T* [(zhenshhin s p)25.3(r)-31.8(ol)-15.7(apsom geni)-23.7(t)15.3(al)-30.7(ij. )]TJ /T1_2 1 Tf [(K)17.3(azanski)11.3(j medicinski)11.3(j zhur)-13.7(nal)]TJ /T1_1 1 Tf 0 Tc 0 Tw (. )Tj 0.023 Tw T* [(2015;96\(4\):498\226505. \(In Russ.\). d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.17750/KMJ2015-498)Tj 0 0 0 1 k /GS1 gs 0.025 Tw T* (27.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (\233\013\031\022)Tj /Span<>> BDC ( )Tj EMC (\202.\206., \204\031\f\017\027)Tj /Span<>> BDC ( )Tj EMC (\236.\236., \205\026\021\022\031\035\035\017\027\026)Tj /Span<>> BDC ( )Tj EMC (\236.\207., \017 \f\024\026\r\021. \025\035\017\027\017\004\036\f\022\017\ \036 )Tj 0.065 Tw -1.796 -1.25 Td (\017)Tj /Span<>> BDC ( )Tj EMC (\020\036\027\036\021\017\004\036\f\022\017\036 \023\026\030\026\035\035\036\ \035\017 \007\017\f\023\035\026\017\017 \f\024\036\007\017\027\017\021\036\ \035\034\027\024\005 \021\022\026\027\017, \023\030\024)Tj 0 Tw (-)Tj 0.006 Tw T* (\035\026\023\f\026 \020\036\027\017\021\026\035\017\005 \017)Tj /Span<>> BDC ( )Tj EMC (\f\017\027\007\030\024\n\026 \020\017\023\036\030\n\024\002\017\035\034\027\ \024\f\021\017 \f\031\f\021\026\r\024\r. )Tj /T1_2 1 Tf 0 Tw (\034\f\033\034\024\032 )Tj 0.336 Tw T* (\013\022\020\016\021\034\027\034\013\022\022, \037\021\023\001\016\033\024\ \035\036\037 \022)Tj /Span<>> BDC ( )Tj EMC (\f\016\033\022\020\037\035\034\027\034\013\022\022. )Tj /T1_1 1 Tf 0 Tw (2018;17\(4\):31\22635. )Tj T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.86 0 Td (10.20953/1726-1678-2018-4-31-35)Tj 0 0 0 1 k /GS1 gs 0.037 Tw [( )0.5(/ )0.5(Y)50(ashchuk)]TJ /Span<>> BDC ( )Tj EMC 19.473 0 Td [(\202.G., )0.5(Musin)]TJ /Span<>> BDC ( )Tj EMC 4.779 0 Td (I.I., )Tj 0.205 Tw -26.113 -1.25 Td [(F)20(a)15(tkull)-30.9(ina)]TJ /Span<>> BDC ( )Tj EMC [(I.B., e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Cl)-31(inical and gene)-11.9(t)-32(ic p)32(ar)-33(allels be)-12(t)-32(ween con)]TJ 0 Tw (-)Tj 0.296 Tw T* [(nec)-16(t)-32(i)-16(ve t)-32(issue disease, geni)-23.9(t)15(al p)24.9(r)-31.9(ol)-16(apse and joint hyper)-15.9(mobil)-31(i)-24(t)-10(y )]TJ 0 Tw T* [(syndr)-32(ome. )]TJ /T1_2 1 Tf 0.053 Tw 4.469 0 Td [(V)32(op)46(r. )0.6(ginek)13(ol. )0.5(akus. )0.6(per)-37(inatol. )0.5(\(Gynecology, )0.5(Obstetr)-36.9(ics )0.6(and )]TJ 0 Tw -4.469 -1.25 Td [(P)15(er)-37(inatology\).)]TJ /T1_1 1 Tf 0.166 Tw [( 2018;17\(4\):31\22635. \(In Russ.\). d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.20953/1726-)Tj T* (1678-2018-4-31-35)Tj 0 0 0 1 k /GS1 gs 0.161 Tw T* (28.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(L)-32(i)]TJ /Span<>> BDC ( )Tj EMC (Z, Xu)Tj /Span<>> BDC ( )Tj EMC [(T, L)-32(i)]TJ /Span<>> BDC ( )Tj EMC [(Z, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC (al. An)Tj /Span<>> BDC ( )Tj EMC [(epidemiol)30(o)-16(gic stud)17(y of)]TJ /Span<>> BDC ( )Tj EMC [(pel)30(v)-16(ic or)-32(gan )]TJ 0.14 Tw -1.796 -1.25 Td [(p)25(r)-32(ol)-16(apse in postmenop)32(ausal w)-14(omen: a)]TJ /Span<>> BDC ( )Tj EMC [(popul)-16(a)15(t)-31.9(ion-based sam)10(ple in )]TJ 0 Tw T* (China. )Tj /T1_2 1 Tf 2.956 0 Td [(Climacter)-36.9(ic.)]TJ /T1_1 1 Tf 0.18 Tw [( 2019;22\(1\):79\22684. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1080/13697137.201)Tj -2.956 -1.25 Td (8.1520824)Tj 0 0 0 1 k /GS1 gs 0.301 Tw T* (29.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Hick)-10(s)]TJ /Span<>> BDC ( )Tj EMC [(CW, W)22(einstein)]TJ /Span<>> BDC ( )Tj EMC [(M, W)12(ak)-17(ama)15(tsu)]TJ /Span<>> BDC ( )Tj EMC [(M, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Ar)-24(e r)-24(ec)-16(t)17(o)-16(celes )]TJ 0.076 Tw -1.796 -1.25 Td [(t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(cause or t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(r)-23.9(esul)56(t of)]TJ /Span<>> BDC ( )Tj EMC [(obstr)-22(uc)-15.9(ted def)16(aeca)15(t)-32(ion syndr)-32(ome? A)]TJ /Span<>> BDC ( )Tj EMC [(p)25(r)-32(o)]TJ 0 Tw (-)Tj -0.001 Tw T* [(spec)-16(t)-32(i)-15.9(ve anor)-24(ec)-16(t)15(al phy)-12.9(siol)30(o)-16(g)16(y stud)17(y. )]TJ /T1_2 1 Tf (Colorectal Dis. )Tj /T1_1 1 Tf 0 Tw (2013;15\(8\):993\226)Tj 0.023 Tw T* [(999. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1111/codi.12213)Tj 0 0 0 1 k /GS1 gs 0.004 Tc 0.349 Tw T* (30.)Tj /Span<>> BDC ( )Tj EMC 1.812 0 Td [(Bhar)-22(ucha)]TJ /Span<>> BDC ( )Tj EMC [(AE, Kno)-13.9(wles)]TJ /Span<>> BDC ( )Tj EMC [(CH. R)13(ec)-16(t)17.1(o)-16(cele: Inc)-23.9(ident)15.1(al or im)10.1(por)]TJ 0 Tc 0 Tw 25.474 0 Td (-)Tj 0.011 Tc 0.403 Tw -27.286 -1.25 Td [(t)15.2(ant? Obser)-31.9(ve or oper)-32.8(a)15.1(te? Contem)10.2(por)-32.8(ar)-23.8(y dia)-16.9(gnosis and man)]TJ 0 Tc 0 Tw (-)Tj 0.005 Tc 0.349 Tw T* [(a)-16.9(gement in t)-12.9(he)]TJ /Span<>> BDC ( )Tj EMC [(mul)56.1(t)-31.9(idisc)-23.9(ipl)-30.9(inar)-23.8(y er)-32.9(a. )]TJ /T1_2 1 Tf [(N)18.1(eurog)12.1(astroenterol Mo)13(til)]TJ /T1_1 1 Tf 0 Tc 0 Tw (. )Tj 0.023 Tw T* [(2022;34\(11\):e14453. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1111/nmo.14453)Tj 0 0 0 1 k /GS1 gs -0.035 Tw T* (31.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Mana)15(t)15(ak)-16(is)]TJ /Span<>> BDC ( )Tj EMC [(DK, Gouv)-14.9(as)]TJ /Span<>> BDC ( )Tj EMC [(N, P)30(echl)-31(i)-16(v)-15(anides)]TJ /Span<>> BDC ( )Tj EMC [(G, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. V)29.9(entr)-32.9(al P)35(r)-32(ost)-13(hesis )]TJ -0.002 Tw -1.796 -1.25 Td [(R)13(ec)-16(t)17(ope)-18(xy for obstr)-22(uc)-16(ted def)16(aeca)15(t)-32(ion syndr)-31.9(ome: a)]TJ /Span<>> BDC ( )Tj EMC [(sy)-13(stema)15(t)-32(ic r)-23.9(ev)-16(iew )]TJ 0.119 Tw T* [(and )0.5(me)-12(t)15(a-anal)35.1(y)-13(sis. )]TJ /T1_2 1 Tf 8.017 0 Td [(U)21(pd)26(ates )0.5(Surg.)]TJ /T1_1 1 Tf [( )0.5(2022;74\(1\):11\22621. )0.5(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw 15.882 0 Td (10.1007/)Tj -23.899 -1.25 Td (s13304-021-01177-2)Tj 0 0 0 1 k /GS1 gs 0.144 Tw T* (32.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Must)15(ain)]TJ /Span<>> BDC ( )Tj EMC [(WC. F)10(unc)-16(t)-32(ional Disor)-23.9(der)-10(s: R)13(ec)-16(t)17(o)-16(cele. )]TJ /T1_2 1 Tf [(Clin Colon R)21(ectal )]TJ 0.013 Tc -0.013 Tw -1.796 -1.25 Td (Surg)Tj /T1_1 1 Tf 0.477 Tw [(. 2017;30\(1\):63\22675. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs -0.013 Tw (10.1055/s-0036-1593425)Tj 0 0 0 1 k /GS1 gs 0.477 Tw [( PMID:)13( )]TJ 0 Tc 0 Tw T* (28144214)Tj 0.095 Tw T* (33.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(T)40(an)]TJ /Span<>> BDC ( )Tj EMC [(C, T)40(an)]TJ /Span<>> BDC ( )Tj EMC (M, Geng)Tj /Span<>> BDC ( )Tj EMC [(J, e)-11.9(t)]TJ /Span<>> BDC ( )Tj EMC [(al. R)13(ec)-16(t)15(al-v)-15(a)-17(ginal p)25(r)-24(essur)-23.9(e gr)-33(adient in )]TJ 0.029 Tw -1.796 -1.25 Td [(p)32(a)15(t)-32(ients wi)-24(t)-13(h pel)30(v)-16(ic or)-32(gan p)25(r)-32(ol)-16(apse and sym)10.1(pt)17(oma)15(t)-32(ic r)-23.9(ec)-16(t)17(o)-16(cele. )]TJ /T1_2 1 Tf 0 Tw (BMC )Tj 0.023 Tw T* [(W)29(omens Health)]TJ /T1_1 1 Tf [(. 2021;21\(1\):165. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1186/s12905-021-01304-6)Tj 0 0 0 1 k /GS1 gs 0.13 Tw T* (34.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(N)-14(o\351)]TJ /Span<>> BDC ( )Tj EMC [(GK, Alk)-16.9(a)15(t)17(out)]TJ /Span<>> BDC ( )Tj EMC [(I, S)-24(chier)-16(meier)]TJ /Span<>> BDC ( )Tj EMC [(S, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. L)-32(ap)32(ar)-31.9(oscopic anter)-37(ior )]TJ -0.018 Tw -1.796 -1.25 Td [(and poster)-37(ior na)15(t)-32(i)-15.9(ve t)-31.9(issue r)-24(ep)32(air: a)]TJ /Span<>> BDC ( )Tj EMC [(new pel)30(v)-16(ic fl)30(o)-16(or app)25(r)-32(oa)-17(ch. )]TJ /T1_2 1 Tf 0 Tw (Minim )Tj 0.065 Tw T* [(In)11(v)16(asiv)13(e Ther Allied T)54(echnol.)]TJ /T1_1 1 Tf [( 2019;28\(4\):241\226246. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1080/136)Tj T* (45706.2018.1510420)Tj 0 0 0 1 k /GS1 gs 0.224 Tw T* (35.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Y)50(ang)]TJ /Span<>> BDC ( )Tj EMC (Y, Cao)Tj /Span<>> BDC ( )Tj EMC (YL, Zhang)Tj /Span<>> BDC ( )Tj EMC [(YY, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Cl)-31(inical ef)-56(f)-28(ica)-17(cy of)]TJ /Span<>> BDC ( )Tj EMC [(integr)-32.9(al )]TJ 0.138 Tw -1.796 -1.25 Td [(t)-13(heor)-23.9(y-guided l)-16(ap)32(ar)-32(oscopic integr)-33(al pel)30(v)-16(ic fl)30(o)-16(or/l)-31(igament r)-24(ep)32(air in )]TJ 0.195 Tw T* [(t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(tr)-23.9(ea)15(tment of)]TJ /Span<>> BDC ( )Tj EMC [(inter)-15(nal r)-24(ec)-15.9(t)15(al p)25(r)-32(ol)-16(apse in females. )]TJ /T1_2 1 Tf [(W)29(orld J Clin )]TJ 0 Tw T* (Cases)Tj /T1_1 1 Tf 0.023 Tw [(. 2020;8\(23\):5876\2265886. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.12998/wjcc.v8.i23.5876)Tj 0 0 0 1 k /GS1 gs 0.081 Tw T* (36.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Jel)30(ovsek)]TJ /Span<>> BDC ( )Tj EMC (JE, Maher)Tj /Span<>> BDC ( )Tj EMC [(C, Bar)-24(ber)]TJ /Span<>> BDC ( )Tj EMC [(MD. 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[(\007)-6(\017)2.7()-9.9(\026\005)1.7(\027 \017)-2.4(\f)3.1(\f)-38.9(\035)-6.8(\036)-19(\007)-4.4(\024)-4.3(\r)-8.9(\026\027)1.8(\017)-5.5(\016)13.7(:)]TJ /T1_2 1 Tf -0.027 Tc -0.039 Tw [( \214)-19.7(\016)-26.9(\035)-21.1(\033)-20.6(\022)-19.8(\020)-23.7(\024)-23(\021)-14.3(\022)-16.8(\004)]TJ /Span<>> BDC 19.92 0 Td ( )Tj EMC [(\247.)0.6(\234.)-19.2(,)-27( )]TJ 0 Tc 0 Tw -19.92 -1.218 Td [(\r)15.6(\034)4.9(\033)7.8(\201)-9.1(\023)8.8(\021)]TJ /Span<>> BDC ( )Tj EMC [(\214)19.5(.)43.7(\207)-2.1(. \210\016)-20.6(\027)3.3(\034)4.9(\023)6.6(\024)9.8(\034)9.7(\036)]TJ /Span<>> BDC ( )Tj EMC [(\205)-2.3(.)20.1(\214)19.4(.)]TJ /T1_0 1 Tf 0.462 Tw T* [(\224)-4.6(\002)-9.9(\024)0.7(\030 \017)]TJ /Span<>> BDC ( )Tj EMC [(\024)-11.8(\002)3(\030)-11.4(\026)-6.3(\002)-9.9(\024)-10.9(\021)-17.7(\022)-19.1(\026 \n)1.3(\026)-11.8(\021)-9.9(\036)-1.6(\030)-7.6(\017)-0.6(\026)-33.1(\035\026)3.7(:)]TJ /T1_2 1 Tf -0.027 Tc 0.489 Tw [( \214)-19.7(\016)-27(\035)-21.1(\033)-20.6(\022)-19.7(\020)-23.7(\024)-23(\021)-14.3(\022)-16.9(\004)]TJ /Span<>> BDC 19.392 0 Td ( )Tj EMC [(\247.)0.5(\234.)-19.2(,)-26.9( )]TJ -0.024 Tc 0.024 Tw -19.392 -1.218 Td [(\214)-15.6(\023\027)-20.7(\016)-21.7(\020)-17.4(\b)-22.1(\016)-24.9(\016)-17.4(\036)]TJ /Span<>> BDC 4.304 0 Td ( )Tj EMC [(\207)-26.1(.)4.5(.)]TJ /T1_0 1 Tf 0.002 Tc 0.069 Tw -4.304 -1.218 Td [(\203)7.2(\026\023)4.2(\017\f)-10.8(\026)1.7(\027)3.7(\017)-6.7(\036)2.1( \021)-7.9(\036)-3.3(\022\f)-34(\021)-19.5(\026)5.7(:)]TJ /T1_2 1 Tf 0 Tc 0.071 Tw 7.765 0 Td [( \214)7.3(\016\035)5.9(\033)6.4(\022)7.2(\020)3.3(\024)4(\021)12.8(\022)10.1(\004)]TJ /Span<>> BDC ( )Tj EMC [(\247)27(.)27.5(\234)26.6(.)7.8(, \207)8.8(\022)3.5(\031)2.2(\034)5.3(\020)3.8(\016)2.3(\020)10.7(\021)9.8(\034)]TJ /Span<>> BDC ( )Tj EMC [(\217)28.8(.)7.4(\205)-2.3(.)7.8(, )]TJ -0.024 Tc 0.024 Tw -7.765 -1.218 Td [(\214)-15.6(\023\027)-20.7(\016)-21.7(\020)-17.4(\b)-22.1(\016)-24.9(\016)-17.4(\036)]TJ /Span<>> BDC 4.304 0 Td ( )Tj EMC [(\207)-26.1(.)4.5(.)]TJ /T1_0 1 Tf 0 Tc 0 Tw -4.304 -1.218 Td [(\217)5.5(\036)-19(\007)-20.1(\026\022)-32.6(\021)-17.7(\017)1.5(\030)-11.8(\024)-4.4(\r)-8.8(\026\027)1.8(\017)-8.7(\036)6.5(:)]TJ /T1_2 1 Tf 0.896 Tw [( \210\016)-20.6(\027)3.3(\034)4.9(\023)6.6(\024)9.8(\034)9.6(\036)]TJ /Span<>> BDC ( )Tj EMC [(\205)-2.3(.)20.1(\214)19.4(.)7.8(, \r)15.6(\034)4.9(\033)7.8(\201)-9.1(\023)8.8(\021)]TJ /Span<>> BDC ( )Tj EMC [(\214)19.4(.)43.7(\207)-2.1(.)7.8(, )]TJ -0.002 Tc 0.002 Tw T* [(\207)6.8(\022)1.5(\031\034)3.3(\020)1.9(\016\020)8.7(\021)7.8(\034)]TJ /Span<>> BDC 4.157 0 Td ( )Tj EMC [(\217)26.8(.)5.3(\205)-4.3(.)5.8(,)]TJ /T1_1 1 Tf 0 Tc 0.023 Tw -4.157 -2.436 Td (AUTHORS CONTRIBUTION)Tj /T1_0 1 Tf 0.191 Tw T* [(C)-6.5(o)0.8(nce)-0.7(p)-12.3(t a)2.4(n)-4.6(d d)-5.5(e)-13.3(s)-16.6(i)3.3(g)1.1(n o)-2.2(f)]TJ /Span<>> BDC ( )Tj EMC [(t)-16.7(h)-5.3(e s)-20(t)-12.8(ud)-10.9(y)-11.7(:)]TJ /T1_2 1 Tf -0.008 Tc 0.199 Tw [( Y)31.3(a)-8.7(n)]TJ /Span<>> BDC 16.093 0 Td ( )Tj EMC [(Y)25.7(u.)-8( M)-5.7(e)-12.4(t)-13.4(r)-43.3(ins)1.1(k)-29.7(y)8.5(,)-8( )]TJ -0.005 Tc 0.005 Tw -16.093 -1.218 Td [(M)5.5(i)2.9(kha)-7(i)2.4(l)]TJ /Span<>> BDC 2.821 0 Td ( )Tj EMC [(S)-2.9(.)]TJ /Span<>> BDC 0.99 0 Td ( )Tj EMC [(K)8.3(o)-3.7(r)-19.6(z)3.1(h)3.2(uk)-22.4(,)-5( A)-1.4(le)-33.5(xa)-5.8(n)-5.7(d)-5.9(e)-6.7(r)]TJ /Span<>> BDC 7.71 0 Td ( )Tj EMC (M.)Tj /Span<>> BDC 1.172 0 Td ( )Tj EMC [(B)-4.2(e)-6.9(l)-2.1(o)-4.1(u)-5.1(so)-5.5(v)]TJ /T1_0 1 Tf 0 Tc 0.289 Tw -12.692 -1.218 Td [(C)-6.5(o)-5.8(l)-19(l)-14.3(e)-9.4(c)-32.5(t)-37.3(i)3.2(o)0.8(n )0.5(a)2.4(n)-4.6(d )0.5(p)-3.8(r)-5.9(o)-7(ce)-13.3(s)-12.8(s)-16.6(i)7.1(n)-1.9(g )0.5(o)-2.2(f)]TJ /Span<>> BDC ( )Tj EMC 12.898 0 Td [(t)-16.7(h)-5.3(e )0.6(m)1.8(a)-8.4(t)-15.2(e)-2.1(r)-48(i)5.1(a)-1.5(l)-22.5(:)]TJ /T1_2 1 Tf [( )0.6(Y)39.3(a)-0.8(n)]TJ /Span<>> BDC ( )Tj EMC 8.016 0 Td [(Y)33.7(u)7.7(. )]TJ 0 Tw -20.914 -1.218 Td [(M)2.3(e)-4.4(t)-5.4(r)-35.3(i)8.4(n)8.1(s)9.1(k)-21.7(y)16.5(, S)5.6(e)-1.7(r)2.3(g)-2.5(e)-2.5(y)]TJ /Span<>> BDC ( )Tj EMC [(V)53.1(.)]TJ /Span<>> BDC ( )Tj EMC [(M)5.6(u)2.8(l)4.8(e)-2.6(n)-0.6(d)-1(e)-6.2(e)-4(v)]TJ /T1_0 1 Tf 1.157 Tw T* [(W)3.1(r)-48(i)-6(t)-37.4(i)7.2(n)-1.9(g o)-2.2(f)]TJ /Span<>> BDC ( )Tj EMC [(t)-16.7(h)-5.3(e t)-15.2(e)-23.9(x)-36(t)-20.1(:)]TJ /T1_2 1 Tf -0.008 Tc 1.165 Tw [( Y)31.3(a)-8.8(n)]TJ /Span<>> BDC 14.16 0 Td ( )Tj EMC [(Y)25.7(u.)-8( M)-5.7(e)-12.4(t)-13.4(r)-43.2(ins)1.1(k)-29.8(y)8.5(,)-8( )]TJ 0 Tc 0 Tw -14.16 -1.218 Td [(N)8(i)7.9(k)12.9(o)-1(l)3.3(a)-5.9(y)]TJ /Span<>> BDC ( )Tj EMC [(A)-12.6(.)]TJ /Span<>> BDC ( )Tj EMC [(S)21.5(i)12.4(z)12.4(on)1.9(e)-2.5(n)7.5(k)12.9(o)-3.7(, S)5.6(e)-1.7(r)2.3(g)-2.5(e)-2.5(y)]TJ /Span<>> BDC ( )Tj EMC [(V)53.2(.)]TJ /Span<>> BDC ( )Tj EMC [(M)5.6(u)2.8(l)4.8(e)-2.6(n)-0.6(d)-1(e)-6.2(e)-3.9(v)]TJ /T1_0 1 Tf 0.006 Tc -0.006 Tw T* [(E)11.6(dit)-31.4(i)13.1(n)4.1(g)15(:)]TJ /T1_2 1 Tf -0.005 Tc 0.351 Tw 3.238 0 Td [( )0.5(A)-1.4(le)-33.6(xa)-5.8(n)-5.6(d)-6(e)-6.7(r)]TJ /Span<>> BDC 4.463 0 Td ( )Tj EMC 0.579 0 Td (M.)Tj /Span<>> BDC 0.939 0 Td ( )Tj EMC 0.579 0 Td [(B)-4.2(e)-6.9(l)-2.1(o)-4.1(u)-5.1(so)-5.6(v)28.6(,)-5( )0.5(M)5.5(i)2.9(kha)-7(i)2.4(l)]TJ /Span<>> BDC 7.041 0 Td ( )Tj EMC 0.579 0 Td [(S)-2.9(.)]TJ /Span<>> BDC 0.757 0 Td ( )Tj EMC 0.579 0 Td [(K)8.3(o)-3.7(r)-19.6(z)3.1(h)3.2(uk)-22.4(,)-5( )]TJ 0 Tc 0 Tw -18.751 -1.218 Td [(N)8(i)7.9(k)12.9(o)-1(l)3.3(a)-5.9(y)]TJ /Span<>> BDC ( )Tj EMC [(A)-12.6(.)]TJ /Span<>> BDC ( )Tj EMC [(S)21.5(i)12.4(z)12.4(on)1.9(e)-2.5(n)7.5(k)12.9(o)]TJ /T1_1 1 Tf 0.023 Tw 23.244 40.187 Td (\255\026\036\031\036\025\034\226 \017\223 \032\026\020\017\022\032\225 \(\ ORCID\))Tj /T1_0 1 Tf 0.163 Tw T* (\204\036\021\030\017\027\f\022\017\005 \233\027 \222\030\034\036\r\017\004\ )Tj /Span<>> BDC ( )Tj EMC (\227 \r\030\026\004-\026\022\031\001\036\030-\020\017\027\036\022\024\035\ \024\020 )Tj 0.266 Tw T* (\031\030\024\035\024\020\017\004\036\f\022\024\020\024 \024\021\007\036\035\ \036\027\017\016 \022\035\017\027\017\022\017 \r\t\f\024\022\017\b \n\036\ \007\017)Tj 0 Tw (-)Tj T* (\006\017\027\f\022\017\b)Tj 5.83 0 0 5.83 337.2765 691.6259 Tm ( )Tj 0.076 Tw 10 0 0 10 339.0804 688.2959 Tm (\021\036\b\027\024\035\024\020\017\005 \017\n\036\027\017 \203.\236. \215\ \017\030\024\020\024\r\026, \205\206\207\210\211 \200\210 )Tj 0.503 Tw -3.577 -1.218 Td (\253\224\026\027\022\021-\215\036\021\036\030\002\031\030\020\f\022\017\005\ \020\024\f\031\007\026\030\f\021\r\036\027\027\t\005 \031\027\017\r\036\ \030\f\017)Tj 0 Tw (-)Tj T* (\021\036\021\273; ORCID 0000-0002-5198-384X)Tj 0.35 Tw 0 -1.218 TD (\207\036\035\024\031\f\024\r \202\035\036\022\f\026\027\007\030 \204\017\ \b\026\005\035\024\r\017\004)Tj /Span<>> BDC ( )Tj EMC (\227 \007.\n.\027., \026\n\036)Tj 0 Tw (-)Tj 0.187 Tw 0 -1.218 TD (\f\021\017\021\036\035\034 \020\035\026\r\027\024\020\024 \r\030\026\004\ \026 \023\024)Tj /Span<>> BDC ( )Tj EMC (\n\036\007\017\006\017\027\f\022\024\005 \004\026\f\021\017 \(\b\017)Tj 0 Tw (-)Tj 0.116 Tw T* (\030\031\030\020\017\016 \017)Tj /Span<>> BDC ( )Tj EMC (\024\027\022\024\035\024\020\017\016\) \022\035\017\027\017\022\017 \r\t\ \f\024\022\017\b \n\036\007\017\006\017\027\f\022\017\b )Tj 0.102 Tw T* (\021\036\b\027\024\035\024\020\017\005 \017\n\036\027\017 \203.\236. \215\ \017\030\024\020\024\r\026, \205\206\207\210\211 \200\210 \253\224\026\027\ \022\021-)Tj 1.227 Tw T* (\215\036\021\036\030\002\031\030\020\f\022\017\005 \020\024\f\031\007\026\ \030\f\021\r\036\027\027\t\005 \031\027\017\r\036\030\f\017\021\036\021\273\ ; )Tj 0 Tw T* (ORCID 0000-0002-2274-8170)Tj 0.35 Tw T* [(\224\017\024\027\036\027\022\024 )0.6(\203\017\022\024\035\026\005 )0.5(\202\035\036\022\f\026\027\007\030\024\r\017\004)]TJ /Span<>> BDC ( )Tj EMC 15.982 0 Td [(\227 )0.5(\022.\n.\027., )0.6(\007\024)]TJ 0 Tw (-)Tj 0.093 Tw -15.982 -1.218 Td (\006\036\027\021 \022\026\235\036\007\030\t \r\024\036\027\027\024-\n\024\ \030\f\022\024\005 \b\017\030\031\030\020\017\017 \205\206\207\200\210\211\ \200\210 )Tj -0.016 Tw T* [(\253\200\024\036\027\027\024-\n\036\007\017\006\017\027\f\022\026\016 )0.6(\026\022\026\007\036\n\017\016 )0.6(\017\n. )0.5(\224.\204. )0.5(\025\017\030\024\r\026\273 )0.5(\204\210 )]TJ 0 Tw T* (\217\205; ORCID 0000-0001-6455-0894)Tj -0.03 Tw T* (\025\024\030\032\031\022 \204\017\b\026\017\035 \224\036\030\020\036\036\ \r\017\004)Tj /Span<>> BDC ( )Tj EMC (\227 \007.\n.\027., \023\030\024\235\036\f\f\024\030, \f\021\026\030)Tj 0 Tw (-)Tj 0.027 Tw T* (\001\017\005 \023\030\036\023\024\007\026\r\026\021\036\035\034 \022\026\ \235\036\007\030\t \r\024\036\027\027\024-\n\024\030\f\022\024\005 \b\017\ \030\031\030)Tj 0 Tw (-)Tj 0.127 Tw T* (\020\017\017 \205\206\207\200\210\211 \200\210 \253\200\024\036\027\027\024\ -\n\036\007\017\006\017\027\f\022\026\016 \026\022\026\007\036\n\017\016\ \017\n. )Tj 0 Tw T* (\224.\204. \025\017\030\024\r\026\273 \204\210 \217\205; ORCID 0000-0002\ -4579-2027)Tj 0.467 Tw T* (\204\031\035\036\027\007\036\036\r \224\036\030\020\036\005 \200\026\f\017\ \035\034\036\r\017\004)Tj /Span<>> BDC ( )Tj EMC (\227 \027\026\004\026\035\034\027\017\022 \024\021)Tj 0 Tw (-)Tj 0.451 Tw T* (\007\036\035\036\027\017\016 \027\036\024\021\035\024\032\027\024\005 \b\ \017\030\031\030\020\017\017 \022\035\017\027\017\022\017 \022\026\235\036\ \007\030\t )Tj 0.592 Tw T* (\r\024\036\027\027\024-\n\024\030\f\022\024\005 \b\017\030\031\030\020\017\ \017 \205\206\207\200\210\211 \200\210 \253\200\024\036\027\027\024-)Tj 0.349 Tw T* (\n\036\007\017\006\017\027\f\022\026\016 \026\022\026\007\036\n\017\016 \ \017\n. \224.\204. \025\017\030\024\r\026\273 \204\210 \217\205; )Tj 0 Tw T* (ORCID 0009-0004-6104-9905)Tj /T1_1 1 Tf 0.023 Tw 0 -2.436 TD (INFORMATION ABOUT THE)Tj /Span<>> BDC ( )Tj EMC (AUTHORS \(ORCID\))Tj /T1_0 1 Tf 0 Tw 0 -1.218 TD [(Y)50(an Y)35(u. Me)-11.9(tr)-37(insk)-32(y)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0002-5198-384X)Tj T* [(Ale)-18(x)-10.9(ander M. Bel)30.1(ousov)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0002-2274-8170)Tj T* [(Nikol)-16(a)15.1(y A. S)-16(izonenko)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0001-6455-0894)Tj T* [(Mikhail S. K)25.1(or)-24(zhuk)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0002-4579-2027)Tj T* [(Ser)-32(ge)-11(y V. Mulendeev)]TJ /Span<>> BDC ( )Tj EMC (\227 0009-0004-6104-9905)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 70.936 286.4219 Tm [(\r\031\024\034\033)48(\026)45(\024)-10(\223\033)48(\026/REFERENCES)]TJ 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.015 Tc 0.545 Tw 8 0 0 8 70.8661 273.5872 Tm (1.)Tj /Span<>> BDC ( )Tj EMC 1.341 0 Td (\202\004\022\026\f\024\r)Tj /Span<>> BDC ( )Tj EMC (\224.\236., \207\035\026\020\024\007\026\030\027\t\005)Tj /Span<>> BDC ( )Tj EMC (\214.\202., \207\024\005\022\024)Tj /Span<>> BDC ( )Tj EMC (\202.\200., \017)Tj /Span<>> BDC ( )Tj EMC [(\f\024\026\r\021.)15( )]TJ 0.011 Tc 0.392 Tw -1.341 -1.25 Td [(\224)0.5(\023\030)0.5(\026)0.5(\r\024)0.5(\004)0.5(\027)0.5(\017\022)0.5( \023)0.5(\024)]TJ /Span<>> BDC ( )Tj EMC [(\022)0.5(\024\035)0.5(\024)0.5(\023\030)0.5(\024)0.5(\022\021)0.5(\024)0.5(\035)0.5(\024\020)0.5(\017)0.5(\017.)0.5( \()0.5(\023\024)0.5(\007)0.5( \030\036)0.5(\007)0.5(. \222)0.5(.)0.5(\202)0.5(. \221)0.5(\036)0.5(\035\t)0.5(\020)0.5(\017\027)0.5(\026)0.5(,)11( )]TJ 0 Tc 0.203 Tw 0 -1.25 TD [(\214.\202. )0.6(\207\035\026\020\024\007\026\030\027\024\020\024\). )0.6(\204.: )0.6(\214\017\021\021\036\030\030\026, )0.6(2014. )0.5(608 )0.6(\f. )0.5(/ )0.6(A)-25(chk)-17(asov)]TJ /Span<>> BDC ( )Tj EMC 26.024 0 Td (S.I., )Tj 0.091 Tw -26.024 -1.25 Td [(Bl)-16(a)-17(god)42(ar)-15(ny)]TJ /Span<>> BDC ( )Tj EMC (L.A., Bojko)Tj /Span<>> BDC ( )Tj EMC [(A.V., e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Sp)25(r)-33(avo)-16(chnik po kol)30(op)25(r)-32(ok)-23.9(t)17(ol)30(o)-16(gi)-16(i / )]TJ 0.044 Tw T* [(pod r)-23.9(ed. Ju.A. S)-15.9(hel)35(ygina, L.A. Bl)-15.9(a)-17(god)42(ar)-15(no)-16(go. M.: L)-32(i)-23.9(t)-30(ter)-24(r)-33(a, 2014. 608 )]TJ 0.023 Tw T* (p. \(In Russ.\).)Tj -0.04 Tw T* (2.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Guzman-Negr)-31.9(on)]TJ /Span<>> BDC ( )Tj EMC 6.643 0 Td [(JM, )0.5(F)20(ascell)-30.9(i)]TJ /Span<>> BDC ( )Tj EMC 4.678 0 Td [(M, )0.5(V)25(asav)-15(ad)42(a)]TJ /Span<>> BDC ( )Tj EMC 4.87 0 Td [(SP. )0.5(P)10(oster)-36.9(ior )0.5(V)25(a)-17(ginal )0.5(W)12(all )]TJ -0.033 Tw -17.487 -1.25 Td [(P)35(r)-32(ol)-16(apse: Sutur)-24(e-Based R)13(ep)32(air. )]TJ /T1_2 1 Tf [(U)22(rolClin N)17(or)-40(th Am)]TJ /T1_0 1 Tf (. 2019;46\(1\):79\22685. )Tj 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1016/j.ucl.2018.08.007)Tj 0 0 0 1 k /GS1 gs 0.006 Tc 0.35 Tw -1.847 -1.25 Td (3.)Tj /Span<>> BDC ( )Tj EMC 1.315 0 Td [(A)-14.4(bhy)21.6(ank)-17.4(ar)]TJ /Span<>> BDC ( )Tj EMC [(P, U)12.5(ny)]TJ /Span<>> BDC ( )Tj EMC [(I, Sem)9.6(ple)]TJ /Span<>> BDC ( )Tj EMC [(K, e)-12.4(t)]TJ /Span<>> BDC ( )Tj EMC [(al. W)19.6(omen\246s e)-18.4(xper)-37.3(iences)6( )]TJ 0 Tc 0.048 Tw -1.315 -1.25 Td (of)Tj /Span<>> BDC ( )Tj EMC [(r)-24(ecei)-16(v)-15.9(ing car)-24(e for pel)30(v)-16(ic or)-32(gan p)25(r)-32(ol)-16(apse: a)]TJ /Span<>> BDC ( )Tj EMC [(qual)-31(i)-23.9(t)15(a)15(t)-32(i)-16(ve stud)17(y. )]TJ /T1_2 1 Tf 0 Tw (BMC )Tj 0.023 Tw T* [(W)29(omens Health.)]TJ /T1_0 1 Tf [( 2019;19\(1\):1\22612. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1186/S12905-019-0741-2)Tj 0 0 0 1 k /GS1 gs 0.012 Tc 0.456 Tw T* (4.)Tj /Span<>> BDC ( )Tj EMC 1.333 0 Td (\212\026\027\017\035\017\027\026)Tj /Span<>> BDC ( )Tj EMC (\210.\202., \200\024\035\022\024\r)Tj /Span<>> BDC ( )Tj EMC (\200.\206. \217\026\f\023\030\024\f\021\030\026\027\036\027\027\024\f\021\ \034 \023\030\024\035\026\023)Tj 0 Tc 0 Tw (-)Tj 0.01 Tc 0.359 Tw -1.333 -1.25 Td [(\f\026 \021\026\024\r\t\b \024\030\020\026\027\024\r \f\030\036\007\017\ \032\036\027\013\017\027)0.5( \030\036\023)0.5(\030\024\007)0.5(\031\022\021\017)0.5(\r\027\024\020\024 \r\024\030\026\f)]TJ 0 Tc 0 Tw (-)Tj T* (\021\026. )Tj /T1_2 1 Tf 0.222 Tw 1.594 0 Td (\016\024\035\020\022\021 \020\034\036\032\002 \006\016\b\022\007\022\020\ \024\021\022\002 \035\016\002\020\034\027\034\013\022\004.)Tj /T1_0 1 Tf ( 2022;29\(1\):29\22633. )Tj 0 Tw -1.594 -1.25 Td [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.858 0 Td (10.24412/1609-2163-2022-1-29-33)Tj 0 0 0 1 k /GS1 gs 0.034 Tw [( / Danil)-30.9(ina)]TJ /Span<>> BDC ( )Tj EMC [(O.A., V)29(olkov)]TJ /Span<>> BDC ( )Tj EMC (V.G. )Tj 0.002 Tc 0.35 Tw -1.858 -1.25 Td [(R)-10.4(asp)24.5(r)-32.4(ostr)-33.5(anennost\246 p)24.6(r)-32.5(ol)-16.4(apsa t)14.5(a)-24.4(zov)-17.4(ykh or)-32.4(ganov sr)-24.4(edi zhenshchin)2( )]TJ 0.349 Tw T* [(r)-23.6(e)0.5(p)25.4(r)-31.6(odu)0.5(k)-23.6(t)-31.6(i)-15.5(vno)-15.5(go v)0.5(ozr)-32.5(ast)15.4(a.)0.5( )]TJ /T1_2 1 Tf [(J)0.5(our)-13.6(n)0.5(al of)]TJ /Span<>> BDC ( )Tj EMC [(N)18.4(e)10.4(w Med)0.5(ica)0.5(l T)54.4(e)0.5(chno)0.5(logi)0.5(es)]TJ /T1_0 1 Tf 0 Tc 0 Tw (. )Tj 0.305 Tw T* [(2022;29\(1\):29\22633. \(In Russ.\). d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.24412/1609-2163-2022-1-)Tj T* (29-33)Tj 0 0 0 1 k /GS1 gs 0.113 Tw 29.055 23.75 Td (5.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (\210\030\026\024\r)Tj /Span<>> BDC ( )Tj EMC (\204.\217., \217\026\007\017\027\f\022\017\005)Tj /Span<>> BDC ( )Tj EMC (\200.\213., \216\026\n\024\001\017\027\026)Tj /Span<>> BDC ( )Tj EMC (\204.\207., \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. \200\020\035\016\007 )Tj 0.038 Tw -1.296 -1.25 Td (\027\026)Tj /Span<>> BDC ( )Tj EMC (\023\026\021\024\020\036\027\036\021\017\004\036\f\022\017\036 \n\036\b\026\ \027\017\n\t \235\024\030\n\017\030\024\r\026\027\017\016 \023\030\024\035\ \026\023\f\026 \021\026\024\r\t\b )Tj 0 Tw T* (\024\030\020\026\027\024\r. )Tj /T1_2 1 Tf 0.331 Tw 4.18 0 Td (\202\033\023\b\020\032\004 \f\037\007\022\016\020\035.)Tj /T1_0 1 Tf [( 2018;16\(1-2\):9\22615. / Or)-33(a)-23.9(zov)]TJ /Span<>> BDC ( )Tj EMC (M.R., )Tj 0.041 Tw -4.18 -1.25 Td [(R)-10(ad)17(zinsk)-15.9(ij)]TJ /Span<>> BDC ( )Tj EMC (V.E., Hamoshina)Tj /Span<>> BDC ( )Tj EMC [(M.B., e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. V)48(zgljad na p)32(a)15(t)17(o)-16(gene)-12(t)-31.9(ichesk)-16(ie )]TJ 0.009 Tw T* [(mehanizmy for)-16(mir)-31.9(ov)-15(anija p)25(r)-32(ol)-15.9(apsa t)15(a)-24(zov)-16.9(yh or)-32(ganov. )]TJ /T1_2 1 Tf [(T)56(rudn)11(yj pacient)]TJ /T1_0 1 Tf 0 Tw (. )Tj 0.023 Tw T* (2018;16\(1-2\):9\22615. \(In Russ.\).)Tj -0.027 Tw T* (6.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Br)-37(i)-23.9(t)17(o)]TJ /Span<>> BDC ( )Tj EMC [(L)35(GO, P)30(er)-24(eir)-33(a)]TJ /Span<>> BDC ( )Tj EMC [(GMV, M)-24(oall)-30.9(i)]TJ /Span<>> BDC ( )Tj EMC [(P, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. A)-25(ge and/or postmenop)32(ausal )]TJ 0.018 Tw -1.296 -1.25 Td [(st)15(a)15(tus as r)-37(isk f)16(a)-17(c)-16(t)17.1(or)-10(s for pel)30.1(v)-16(ic or)-32(gan p)25(r)-32(ol)-15.9(apse devel)30.1(opment: sy)-13(stem)]TJ 0 Tw (-)Tj 0.031 Tw T* [(a)15(t)-32(ic r)-24(ev)-15.9(iew wi)-24(t)-13(h me)-11.9(t)15(a-anal)35(y)-13(sis. )]TJ /T1_2 1 Tf [(Int U)22(rogynecol)]TJ /Span<>> BDC ( )Tj EMC (J)Tj /T1_0 1 Tf (. 2022;33\(1\):15\22629. )Tj 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1007/s00192-021-04953-1)Tj 0 0 0 1 k /GS1 gs 0.065 Tw -1.847 -1.25 Td (7.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (\204\026\035\b\026\f\016\027)Tj /Span<>> BDC ( )Tj EMC 4.23 0 Td (\200.\202., \202\002\030\026\n\016\027)Tj /Span<>> BDC ( )Tj EMC 6.051 0 Td [(\025.\203. \225\023\017\007\036\n\017\024\035\024\020\017\016, )0.5(\023\026\021\024\020\036\027\036 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC (\235\026\022)Tj 0 Tw (-)Tj 0.293 Tw -11.577 -1.25 Td (\021\024\030\t \030\017\f\022\026 \023\030\024\035\026\023\f\026 \020\036\ \027\017\021\026\035\017\005 \031)Tj /Span<>> BDC ( )Tj EMC (\032\036\027\013\017\027: \024\002\024\030 \026\030\031\002\036\032\027\ \024\005 )Tj 0 Tw T* (\035\017\021\036\030\026\021\031\030\t. )Tj /T1_2 1 Tf 0.263 Tw 5.54 0 Td (\202\022\002\034\034\021\016\037\020\024\021\022\004 \006\016\b\022\007\022\ \020\024\021\022\004 \201\023\033\020\037\027)Tj /T1_0 1 Tf (. 2011;1\(43\):9\226)Tj 0.247 Tw -5.54 -1.25 Td [(13. / Malkhasy)22(an)]TJ /Span<>> BDC ( )Tj EMC [(V.A., A)-13.9(br)-33(amy)22(an)]TJ /Span<>> BDC ( )Tj EMC [(K.N. Epidemiol)30(o)-16(g)16(y, p)32(a)15(t)-13(hophy)-13(si)]TJ 0 Tw (-)Tj 0.29 Tw T* [(ol)30(o)-16(gic mechanis)26.1(ms and r)-37(isk f)16(a)-17(c)-16(t)17(or)-9.9(s for female geni)-23.9(t)15(al p)25(r)-32(ol)-16(apse: )]TJ 0.07 Tw T* [(for)-24(eign l)-31(i)-24(ter)-32.9(a)15(tur)-24(e r)-24(ev)-15.9(iew. )]TJ /T1_2 1 Tf [(P)18(acif)-42.9(ic Medical Jour)-13.9(nal)]TJ /T1_0 1 Tf (. 2011;1\(43\):9\22613. )Tj 0.023 Tw T* (\(In Russ.\).)Tj 0.123 Tw T* (8.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(K)25(unchar)-33(apu)]TJ /Span<>> BDC ( )Tj EMC [(I, Majer)-31.9(oni)]TJ /Span<>> BDC ( )Tj EMC (BA, Johnson)Tj /Span<>> BDC ( )Tj EMC [(DW. P)30(el)30(v)-16(ic or)-32(gan p)25(r)-32(ol)-16(apse. )]TJ /T1_2 1 Tf 0.023 Tw -1.296 -1.25 Td [(Am F)15(am Ph)12(ysician)]TJ /T1_0 1 Tf (. 20101;81\(9\):1111\2261117.)Tj 0.12 Tw T* (9.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(O)-24(ver)-9.9(sand)]TJ /Span<>> BDC ( )Tj EMC [(SH, S)15.1(t)15(af)-56(f)]TJ /Span<>> BDC ( )Tj EMC [(A)16(C, Spydsl)-16(aug)]TJ /Span<>> BDC ( )Tj EMC [(AE, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. L)35(ong-ter)-15.9(m foll)30(o)-14(w-up )]TJ 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 0 Tw 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\206)10(\002\036\033 \035\030\032\003\033)30(\n)42(\032)-21(\230\033\241)]TJ 57.136 0 Td (REVIEW)Tj -57.136 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 2)69(4, \023\0224, 202)23(5)]TJ 43.013 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 2)69(4, \023\0224, 202)23(5)]TJ /T1_5 1 Tf 25 0 0 25 20.79 56.0378 Tm (196)Tj ET endstream endobj 871 0 obj <>/Border[0 0 0]/H/N/Rect[85.6442 200.883 172.971 191.587]/Subtype/Link/Type/Annot>> endobj 872 0 obj <>/Border[0 0 0]/H/N/Rect[197.826 170.883 291.89 161.427]/Subtype/Link/Type/Annot>> endobj 873 0 obj <>/Border[0 0 0]/H/N/Rect[85.7273 130.883 201.719 121.587]/Subtype/Link/Type/Annot>> endobj 874 0 obj <>/Border[0 0 0]/H/N/Rect[194.793 100.883 291.968 91.5872]/Subtype/Link/Type/Annot>> endobj 875 0 obj <>/Border[0 0 0]/H/N/Rect[70.8661 90.8833 89.6821 81.5872]/Subtype/Link/Type/Annot>> endobj 876 0 obj <>/Border[0 0 0]/H/N/Rect[318.085 190.883 415.557 181.587]/Subtype/Link/Type/Annot>> endobj 882 0 obj <> endobj 881 0 obj <> endobj 880 0 obj <> endobj 879 0 obj <> endobj 878 0 obj <> endobj 877 0 obj <> endobj 73 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 74 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 75 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 76 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 77 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 887 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\033\016\017)-10(\026)11(\025\212\016\t\016 \200\022\216\016\215\232\021\215: \215\016\201\016\020\ \016\215\215\220\016 \r\025\222\201\025\b\220 \(\025\235\213\025\201\022\ \t\021\026)11(\016\201\001\026)-20(\200\201\220\))]TJ 41.66 0 Td [(Rectocele in females: unr)31(esolv)12(ed issues \(r)31(e)11(vie)11(w\))]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0.105 Tw 10 0 0 10 42.5197 724.8299 Tm (\202\r\021\024\030\t \023\024\022\026\026\035\017, \004\021\024 \230\003\ \025\203\230, \023\024)Tj /Span<>> BDC ( )Tj EMC (\f\030\026\r\027\036\027\017\033 \f)Tj /Span<>> BDC ( )Tj EMC (\021\030\026\027\f)Tj 0 Tw (-)Tj 0.136 Tw 0 -1.218 TD (\026\027\026\035\034\027\t\n \023\024\007\b\024\007\024\n, \023\030\017\r\ \036\035\026 \022)Tj /Span<>> BDC ( )Tj EMC (\035\031\004\001\017\n \030\036\031\035\034\021\026\021\026\n )Tj 0.037 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\024\021\027\024\001\036\027\017\017 \022\024\027\f\021\017\023\026\006\017\ \017 \(25% \023\030\024\021\017\r 50%\), \027\036\023\024\035)Tj 0 Tw (-)Tj 0.204 Tw T* (\027\024\020\024 \024\023\024\030\024\032\027\036\027\017\016 \(25% \023\ \030\024\021\017\r 56%\), \017\f\023\024\035\034\024\r\026)Tj 0 Tw (-)Tj 0.169 Tw T* [(\027\017\016 )0.5(\023\026\035\034\006\036\r\024\020\024 \023\024\f\024\002\017\016 )0.5(\023\030\017)]TJ /Span<>> BDC ( )Tj EMC 12.76 0 Td [(\007\036\235\036\022\026\006\017\017 )0.5(\(25% \023\030\024)]TJ 0 Tw (-)Tj 0.171 Tw -12.76 -1.218 Td (\021\017\r 50%\) \017)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\036\027\036\027\027\024\020\024 \f\021\031\035\026 \(19% \023\ \030\024\021\017\r 50%\), )Tj 0.039 Tw 0 -1.218 TD (\023\030\017)Tj /Span<>> BDC ( )Tj EMC (\027\026\002\035\033\007\036\027\017\017 \004\036\030\036 6 \n\036\f\016\ \006\036\r. \232\036\030\036 12 \n\036\f\016\006\036\r, )Tj 0 -1.218 TD (Nieminen \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. [119] \023\030\024\007\036\n\024\027\f\021\030\017\030\ \024\r\026\035\017 \031\n\036\027\034)Tj 0 Tw (-)Tj 0.253 Tw T* [(\001\036\027\017\036 \023\024\021\030\036\002\027\024\f\021\017 )0.5(\017\f\023\024\035\034\024\r\026\027\017\017 \023\026\035\034\006\036\r\ \024\020\024 )0.5(\023\024)]TJ 0 Tw (-)Tj 0.036 Tw T* (\f\024\002\017\016 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\024\023\024\030\024\032\027\036\027\017\017 \023\030\016\n\024\005 \022\ \017\001\022\017 \023\024\f\035\036 \024\023\036\030\026)Tj 0 Tw (-)Tj 0.112 Tw T* (\006\017\017 \r)Tj /Span<>> BDC ( )Tj EMC (\024\002\036\017\b \020\030\031\023\023\026\b \(\f 73% \007\024)Tj /Span<>> BDC ( )Tj EMC (7% \017)Tj /Span<>> BDC ( )Tj EMC (\f 66% \007\024)Tj /Span<>> BDC ( )Tj EMC (27% )Tj -0.045 Tw T* (\023\030\017)Tj /Span<>> BDC ( )Tj EMC (\021\030\026\027\f\r\026\020\017\027\026\035\034\027\024\n \017)Tj /Span<>> BDC ( )Tj EMC (\021\030\026\027\f\026\027\026\035\034\027\024\n \023\024\007\b\024\007\026\ \b, \f\024)Tj 0 Tw (-)Tj 0.036 Tw 0 -1.218 TD (\024\021\r\036\021\f\021\r\036\027\027\024\). \217\026\027\036\r\026\016\ \017\027\235\036\022\006\017\016 \027\026\002\035\033\007\026\035\026\f\ \034 \r)Tj /Span<>> BDC ( )Tj EMC (6% )Tj 0.355 Tw 0 -1.218 TD (\f\035\031\004\026\036\r \023\030\017)Tj /Span<>> BDC ( )Tj EMC [(\023\030\017\n\036\027\036\027\017\017 )0.5(\021\030\026\027\f\026\027\026\035\034\027\024\020\024 \023\024\007\b\024\ \007\026 )]TJ -0.001 Tw 0 -1.218 TD (\r)Tj /Span<>> BDC ( )Tj EMC (\b\017\030\031\030\020\017\004\036\f\022\024\n \035\036\004\036\027\017\017\ \215\217\037 [119]. \212\017\f\023\026\030\036\031\027\017\016 )Tj /T1_2 1 Tf 0 Tw (de )Tj T* [(nov)13(o)]TJ /T1_1 1 Tf ( \027\036 \027\026\002\035\033\007\026\035\026\f\034 \027\017 \r)Tj /Span<>> BDC ( )Tj EMC (\024\007\027\024\005 \017)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023.)Tj 0.127 Tw T* [(\230\036\b\027\017\022\026 \230\003\025\203\230 )0.5(\023\030\024\007\036\n\024\027\f\021\030\017\030\024\r\026\035\026 \035\031\ \004\001\036\036 \r\024\f\f\021\026)]TJ 0 Tw (-)Tj 0.1 Tw T* (\027\024\r\035\036\027\017\036 \f\021\030\031\022\021\031\030\t \003\224\ \200 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\024\f\n\024\021\030\036, \027\024 \027\036 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\007\036)Tj 0 Tw (-)Tj 0.798 Tw T* (\235\036\022\024\020\030\026\235\017\017. \232\026\f\021\024\021\026 \023\ \030\024\016\r\035\036\027\017\016 \022\024\027\f\021\017\023\026\006\017\ \017, )Tj 0.212 Tw T* (\027\036\023\024\035\027\024\020\024 \024\023\024\030\024\032\027\036\027\ \017\016 \f\027\017\017\035\026\f\034 \r)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\034\001\036\005 \f\021\036)Tj 0 Tw (-)Tj 0.103 Tw T* (\023\036\027\017 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\021\030\026\027\f\r\026\020\017\027\026\035\034\027\024\n \r\n\036\001\026\ \021\036\035\034\f\021\r\036. \232\026\f\021\024\021\026 )Tj 0.258 Tw T* (\027\036\002\035\026\020\024\023\030\017\016\021\027\t\b \016\r\035\036\027\ \017\005 \002\t\035\026 \027\017\022\024\005 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\024\002\024\017\b )Tj 0 Tw T* (\n\036\021\024\007\026\b.)Tj 0.15 Tw T* (\200\t\023\024\035\027\017\r \023\024\r\021\024\030\027\t\036 \024\023\036\ \030\026\006\017\017 \023\026\006\017\036\027\021\022\026\n \f)Tj /Span<>> BDC ( )Tj EMC (\030\036\006\017)Tj 0 Tw (-)Tj -0.026 Tw T* (\007\017\r\024\n \215\217\037 \(433)Tj /Span<>> BDC ( )Tj EMC (\227 \230\003\025\203\230, \026)Tj /Span<>> BDC ( )Tj EMC (193)Tj /Span<>> BDC ( )Tj EMC (\227 \017\n\023\035\026\027\021\026\006\017\033 \f\017\027)Tj 0 Tw (-)Tj -0.013 Tw T* [(\021\036\021\017\004\036\f\022\024\020\024 )0.6(\017\n\023\035\026\027\021\026\021\026\), )0.5(\020\030\031\023\023\026 )0.6(\b\017\030\031\030\020\024\r )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 18.809 0 Td (\221\r\036\006\017\017 )Tj 0.264 Tw -18.809 -1.218 Td (\023\030\017\001\035\026 \022)Tj /Span<>> BDC ( )Tj EMC (\r\t\r\024\007\031, \004\021\024 \023\024\035\024\032\017\021\036\035\034\ \027\t\005 \024\021\007\026\035\036\027\027\t\005 )Tj 0.446 Tw T* [(\220\235\235\036\022\021 )0.6(\f\017\027\021\036\021\017\004\036\f\022\024\020\024 )0.5(\017\n\023\035\026\027\021\026\021\026 )0.5(\023\036\030\036\r\036\001\017\r\026\036\021 )]TJ 0 Tw T* (\030\017\f\022 \024\f\035\024\032\027\036\027\017\005 [120].)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 42.5896 347.3118 Tm [(\037\036)10(\032\223\212\226\034\022\031\034)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0 Tc 0.171 Tw 10 0 0 10 42.5197 322.9558 Tm (\202\027\026\035\017 \007\026\027\027\t\b \023\024\r\024\035\016\036\021\ \f\007\036\035\026\021\034 \030\016\007 \026\022\035\033\004\036\027\017\ \005. )Tj 0.177 Tw T* (\210\023\036\030\026\006\017\017 \027\026)Tj /Span<>> BDC ( )Tj EMC (\026\007\027\036\005 \f\021\036\027\022\036 \r\035\026\020\026\035\017\013\ \026, \027\036\026\r\017\f\017\n\024 )Tj 0.222 Tw T* (\024\021 \021\036\b\027\017\022\017, \f)Tj /Span<>> BDC ( )Tj EMC (\r\t\f\024\022\024\005 \004\026\f\021\024\021\024\005 \031\035\031\004\001\ \026\033\021 \f\021\030\031\022\021\031)Tj 0 Tw (-)Tj 0.166 Tw T* (\030\031 \026\007\027\036\005 \f\021\036\027\022\017 \017)Tj /Span<>> BDC ( )Tj EMC (\f \n\036\027\034\001\036\005)Tj /Span<>> BDC ( )Tj EMC (\227 \f\027\017\032\026\033\021 \004\026\f\021\024\021\031 )Tj 0.375 Tw T* (\f\017\n\023\021\024\n\026\021\017\004\036\f\022\017\b \023\030\024\016\r\ \035\036\027\017\005 \215\217\037. \210\007\027\026\022\024 \035\017\001\ \034 )Tj 0.074 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\027\036\n\027\024\020\017\b \023\030\036\007\f\021\026\r\035\036\027\027\ \t\b \r)Tj /Span<>> BDC ( )Tj EMC (\027\026\f\021\024\016\013\036\n \024\002\024\030\036 \017\f)Tj 0 Tw (-)Tj -0.035 Tw T* [(\f\035\036\007\024\r\026\027\017\016\b )0.6(\023\030\024\r\024\007\017\035\024\f\034 )0.5(\027\026\002\035\033\007\036\027\017\036 )0.6(\007\024\035\034\001\036 )0.5(24)]TJ /Span<>> BDC ( )Tj EMC 20.72 0 Td (\n\036)Tj 0 Tw (-)Tj 0.22 Tw -20.72 -1.218 Td (\f\016\006\036\r \023\024\f\035\036 \b\017\030\031\030\020\017\004\036\f\ \022\024\020\024 \r\n\036\001\026\021\036\035\034\f\021\r\026. \025\030\024\ \n\036 )Tj 0.013 Tw T* (\021\024\020\024, \n\026\035\024 \022\024\035\017\004\036\f\021\r\024 \017\ \f\f\035\036\007\024\r\026\027\017\005, \027\036\023\024\f\030\036\007\f\ \021\r\036\027)Tj 0 Tw (-)Tj 0.184 Tw T* (\027\024 \f\030\026\r\027\017\r\026\033\013\017\b \b\017\030\031\030\020\ \017\004\036\f\022\017\036 \023\024\007\b\024\007\t, \f)Tj /Span<>> BDC ( )Tj EMC (\006\036\035\034\033 )Tj -0.005 Tw T* (\024\023\030\036\007\036\035\036\027\017\016, \f\031\013\036\f\021\r\031\ \036\021 \035\017 \024\023\036\030\026\006\017\016 \007\035\016 \022\024\ \030\030\036\022\006\017\017 )Tj 0 Tw T* (\215\217\037, \023\030\036\r\024\f\b\024\007\016\013\026\016 \230\003\025\ \203\230.)Tj 0.639 Tw T* (\225\235\235\036\022\021\017\r\027\024\f\021\034 \017\n\023\035\026\027\021\ \026\006\017\017 \002\017\024\035\024\020\017\004\036\f\022\017\b \017\035\ \017 )Tj 0.173 Tw T* (\f\017\027\021\036\021\017\004\036\f\022\017\b \021\030\026\027\f\023\035\ \026\027\021\026\021\024\r \027\036 \r\t\001\036, \004\036\n \230\003\025\ \203\230, )Tj 0.235 Tw T* (\026)Tj /Span<>> BDC ( )Tj EMC (\004\017\f\035\024 \023\024\021\036\027\006\017\026\035\034\027\t\b \024\ \f\035\024\032\027\036\027\017\005, \r\022\035\033\004\026\016 \007\017\f\ )Tj 0 Tw (-)Tj 0.259 Tw T* (\023\026\030\036\031\027\017\033 \017)Tj /Span<>> BDC ( )Tj EMC (\220\030\024\017\017 \f\017\027\021\036\021\017\004\036\f\022\024\020\024\ \017\n\023\035\026\027\021\026\021\026)Tj /Span<>> BDC ( )Tj EMC (\227 )Tj 0.362 Tw T* (\r\t\001\036. \204\036\f\021\027\024\036 \006\036\035\036\027\026\023\030\ \026\r\035\036\027\027\024\036 \031\f\021\030\026\027\036\027\017\036 \007\ \036)Tj 0 Tw (-)Tj 0.04 Tw T* (\235\036\022\021\024\r \024\023\024\030\027\t\b \f\021\030\031\022\021\031\ \030 \003\224\200 \f\024\023\030\024\r\024\032\007\026\036\021\f\016 \002\ \024\035\036\036 )Tj -0.02 Tw T* (\r\t\f\024\022\024\005 \004\026\f\021\024\021\024\005 \026\027\026\021\024\ \n\017\004\036\f\022\017\b \030\036\006\017\007\017\r\024\r, \f\017\n\023\ \021\024)Tj 0 Tw (-)Tj 0.055 Tw T* (\n\024\r \215\230\210 \017)Tj /Span<>> BDC ( )Tj EMC (\022\024\027\f\021\017\023\026\006\017\017 \f)Tj /Span<>> BDC ( )Tj EMC (\026\027\026\035\024\020\017\004\027\t\n\017 \023\024\022\026\026\021\036\ \035\016)Tj 0 Tw (-)Tj T* (\n\017 \023\024\f\035\036\024\023\036\030\026\006\017\024\027\027\024\005\ \007\017\f\023\026\030\036\031\027\017\017.)Tj 0.112 Tw 23.244 64.543 Td (\230\030\026\027\f\026\027\026\035\034\027\t\005 \023\024\007\b\024\007 \ \022\024\030\030\036\022\006\017\017 \215\217\037 \f\r\016\026\027 \f)Tj /Span<>> BDC ( )Tj EMC (\002\024)Tj 0 Tw (-)Tj 0.489 Tw 0 -1.218 TD (\035\036\036 \r\t\f\024\022\024\005 \004\026\f\021\024\021\024\005 \026\027\ \026\021\024\n\017\004\036\f\022\017\b \030\036\006\017\007\017\r\024\r \ )Tj 0 Tw 0 -1.218 TD (\017)Tj /Span<>> BDC ( )Tj EMC (\b\031\007\001\017\n \030\026\030\036\001\036\027\017\036\n \224\210\212\ .)Tj 0.217 Tw 0 -1.218 TD (\224\021\036\023\035\036\030\027\026\016 \021\030\026\027\f\026\027\026\035\ \034\027\026\016 \030\036\036\022\006\017\016 \023\030\016\n\024\005 \022\ \017\001\022\017 )Tj -0.014 Tw 0 -1.218 TD (\026\f\f\024\006\017\017\030\024\r\026\027\026 \f)Tj /Span<>> BDC ( )Tj EMC (\031\035\031\004\001\036\027\017\036\n \026\027\026\021\024\n\017\017 \003\ \224\200 \(\020\035\026\r\027\t\n )Tj 0.263 Tw 0 -1.218 TD [(\024\002\030\026\024\n, \023\024\007\021\r\036\030\032\007\036\027\027\t\ \n )0.5(\030\026\007\017\024\035\024\020\017\004\036\f\022\017\) \017)]TJ /Span<>> BDC ( )Tj EMC (\030\026)Tj 0 Tw (-)Tj 0.138 Tw 0 -1.218 TD (\030\036\001\036\027\017\036\n \224\210\212 \023\024\f\035\036 \r\n\036\001\ \026\021\036\035\034\f\021\r\026. \212\026\027\027\t\005 \n\036\021\024\007\ )Tj 0.278 Tw 0 -1.218 TD (\r\n\036\001\026\021\036\035\034\f\021\r\026 \r\t\023\024\035\027\016\036\ \021\f\016, \023\030\036\017\n\031\013\036\f\021\r\036\027\027\024, \022\ \024)Tj 0 Tw (-)Tj 0.197 Tw T* (\035\024\030\036\022\021\026\035\034\027\t\n\017 \b\017\030\031\030\020\026\ \n\017 \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\017\n\036\027\016\036\021\f\016, \r)Tj /Span<>> BDC ( )Tj EMC (\024\f\027\024\r)Tj 0 Tw (-)Tj 0.166 Tw T* [(\027\024\n, \007\035\016 \024\002\035\036\020\004\036\027\017\016 )0.5(\f\017\n\023\021\024\n\024\r, \027\036 )0.5(\031\007\036\035\016\016 )0.5(\024\f\024\002\024\020\024 )]TJ -0.025 Tw T* (\r\027\017\n\026\027\017\016 \023\030\024\n\036\032\027\024\f\021\017, \r\ )Tj /Span<>> BDC ( )Tj EMC (\021\024\n \004\017\f\035\036 \f\021\026\007\017\017 \023\024)Tj /Span<>> BDC ( )Tj EMC (POP-Q. )Tj 0.065 Tw T* (\200)Tj /Span<>> BDC ( )Tj EMC (\017\031\004\036\027\027\t\b \017\f\021\024\004\027\017\022\026\b \f\024\ \024\002\013\026\035\024\f\034 \024)Tj /Span<>> BDC ( )Tj EMC (\r\t\f\024\022\024\005 \004\026\f)Tj /Span<>> BDC (-)Tj EMC 0.205 Tw T* (\021\024\021\036 \022\030\024\r\024\021\036\004\036\027\017\005, \017\027\ \235\036\022\006\017\005 \017)Tj /Span<>> BDC ( )Tj EMC (\f\021\036\027\024\024\r. \224\017\027\007\030\024\n )Tj 0.014 Tw T* (\017\n\023\036\030\026\021\017\r\027\t\b \023\024\t\r\024\r \022)Tj /Span<>> BDC ( )Tj EMC (\007\036\235\036\022\026\006\017\017, \b\024\021\016 \017)Tj /Span<>> BDC ( )Tj EMC (\016\r\035\016\036\021\f\016 )Tj T* (\030\026\f\023\030\024\f\021\030\026\027\036\027\027\t\n, \027\017\r\036\ \035\017\030\031\036\021\f\016 \r)Tj /Span<>> BDC ( )Tj EMC (\021\036\004\036\027\017\036 \027\036\f\022\024\035\034)Tj 0 Tw (-)Tj T* (\022\017\b \n\036\f\016\006\036\r.)Tj 0.13 Tw T* [(\225\235\235\036\022\021\017\r\027\024\f\021\034 )0.6(\b\017\030\031\030\020\017\004\036\f\022\024\020\024 )0.6(\035\036\004\036\027\017\016 )0.5(\215\217\037 )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC 20.307 0 Td (\215\230\210, )Tj 0.021 Tw -20.307 -1.218 Td (\f\024\023\030\016\032\036\027\027\024\020\024 \f)Tj /Span<>> BDC ( )Tj EMC (\031\f\021\030\026\027\036\027\017\036\n \007\036\235\036\022\021\024\r \ \023\030\024\n\036\032\027\024\f\021\017 )Tj 0.041 Tw T* (\(\023\036\030\017\027\036\024\023\035\026\f\021\017\022\026\) \027\026)Tj /Span<>> BDC ( )Tj EMC (\007\026\027\027\t\005 \n\024\n\036\027\021 \r\030\036\n\036\027\017 \027\ \036\016\f)Tj 0 Tw (-)Tj 0.029 Tw T* (\027\026, \017\f\b\024\007\016 \017)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\020\024, \r\024\f\f\021\026\027\024\r\017\021\036\035\034\027\ \t\036 \n\036\030\024\023\030\017\016\021\017\016 )Tj 0.198 Tw T* (\023\030\024\n\036\032\027\024\f\021\017 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\036\201 \027\026\030\031\001\036\027\017\016\b \023\030\036\007\f\021\026\ \r\035\016\033\021 \024\021)Tj 0 Tw (-)Tj 0.112 Tw T* (\007\036\035\034\027\031\033 \f\235\036\030\031 \027\026\031\004\027\024\ \020\024 \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\026\022\021\017\004\036\f\022\024\020\024 \017\027\021\036\030\036\ \f\026. )Tj 0.022 Tw T* (\230\026\022\017\n \024\002\030\026\024\n, \027\036\021 \036\007\017\027\ \024\020\024 \n\027\036\027\017\016 \024)Tj /Span<>> BDC ( )Tj EMC (\027\026\017\035\031\004\001\036\005 \n\036)Tj 0 Tw (-)Tj T* (\021\024\007\017\022\036 \b\017\030\031\030\020\017\004\036\f\022\024\020\ \024 \035\036\004\036\027\017\016 \030\036\022\021\024\006\036\035\036.)Tj 0.097 Tw T* (\203\026 \f\036\020\024\007\027\016\001\027\017\005 \007\036\027\034 \017\ \n\036\036\021\f\016 \024\022\024\035\024 300 \030\026\035\017\004\027\t\ \b )Tj 0.407 Tw T* (\021\036\b\027\017\022 \b\017\030\031\030\020\017\004\036\f\022\024\020\024\ \035\036\004\036\027\017\016 \215\217\037. \224\021\024\030\024\027\027\ \017\022\017 )Tj 0.084 Tw T* (\022\026\032\007\024\020\024 \b\017\030\031\030\020\017\004\036\f\022\024\ \020\024 \023\024\007\b\024\007\026 \f\021\026\030\026\033\021\f\016 \024\ \023\030\036\007\036)Tj 0 Tw (-)Tj -0.026 Tw T* [(\035\017\021\034 )0.5(\023\024\022\026\026\027\017\016, )0.6(\023\030\017)]TJ /Span<>> BDC ( )Tj EMC 8.454 0 Td [(\022\024\021\024\030\t\b )0.5(\017\b )0.6(\n\036\021\024\007\017\022\026 )0.5(\002\031\007\036\021 )0.5(\023\030\036\007)]TJ 0 Tw (-)Tj 0.131 Tw -8.454 -1.218 Td (\023\024\004\021\017\021\036\035\034\027\036\036. \236\027\021\036\030\036\ \f\027\024 \024\021\n\036\021\017\021\034, \004\021\024 \r)Tj /Span<>> BDC ( )Tj EMC (\027\026\f\021\024\016\013\036\036 )Tj 0.3 Tw T* [(\r\030\036\n\016 )0.5(\030\024\035\034 )0.5(\f\021\030\031\022\021\031\030\027\t\b )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 12.174 0 Td [(\235\031\027\022\006\017\024\027\026\035\034\027\t\b )0.6(\017\n\036)]TJ 0 Tw (-)Tj 0.106 Tw -12.174 -1.218 Td (\027\036\027\017\005 \023\030\024\n\036\032\027\024\f\021\017 \r)Tj /Span<>> BDC ( )Tj EMC (\030\026\r\017\021\017\017 \215\230\210 \017)Tj /Span<>> BDC ( )Tj EMC (\215\217\037 \024\f\021\026\036\021\f\016 )Tj 0.322 Tw T* [(\027\036\007\024\f\021\026\021\024\004\027\024 \017\031\004\036\027\027\ \024\005. )0.5(\204\027\024\020\017\036 \235\026\022\021\024\030\t \r\035\017\016\033\021\ )]TJ 0.087 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC (\024\023\030\036\007\036\035\036\027\017\036 \021\024\020\024, \022\026\022\ \024\005 \024\002\255\036\n \024\023\036\030\026\021\017\r\027\024\020\024\ \035\036)Tj 0 Tw (-)Tj 0.134 Tw T* (\004\036\027\017\016 \017)Tj /Span<>> BDC ( )Tj EMC (\007\024\f\021\031\023 \002\031\007\036\021 \027\026\017\002\024\035\036\ \036 \023\024\007\b\024\007\016\013\017\n. \025)Tj /Span<>> BDC ( )Tj EMC (\027\017\n )Tj 0.038 Tw T* (\024\021\027\024\f\016\021\f\016 \r\024\030\026\f\021 \023\026\006\017\036\ \027\021\022\017, \007\035\017\027\026 \r\035\026\020\026\035\017\013\026\ , \r\026\032)Tj 0 Tw (-)Tj 0.064 Tw T* (\027\024\f\021\034 \f\024\b\030\026\027\036\027\017\016 \f\036\022\f\031\ \026\035\034\027\024\005 \235\031\027\022\006\017\017, \f\021\026\007\017\ \016 \215\230\210, )Tj 0.049 Tw T* (\030\036\006\017\007\017\r\017\030\031\033\013\036\036 \021\036\004\036\027\ \017\036 \017)Tj /Span<>> BDC ( )Tj EMC (\r\t\030\026\032\036\027\027\024\f\021\034 \224\210\212 \017)Tj /Span<>> BDC ( )Tj EMC (\007\030. )Tj 0.308 Tw T* (\200\n\036\f\021\036 \f)Tj /Span<>> BDC ( )Tj EMC (\021\036\n, \f\035\036\007\031\036\021 \024\021\n\036\021\017\021\034, \004\ \021\024 \024\021\027\024\f\017\021\036\035\034\027\024 )Tj 0.02 Tw T* (\n\026\035\024\036 \r\027\017\n\026\027\017\036 \017\f\f\035\036\007\024\ \r\026\021\036\035\016\n\017 \031\007\036\035\016\036\021\f\016 \r\t\016\ \f\027\036)Tj 0 Tw (-)Tj -0.022 Tw T* (\027\017\033 \f\024\f\021\024\016\027\017\016 \021\022\026\027\036\005 \f\ \024\r\030\036\n\036\027\027\t\n\017 \n\036\021\024\007\026\n\017 \r\017\ \031)Tj 0 Tw (-)Tj 0.121 Tw T* (\026\035\017\026\006\017\017)Tj /Span<>> BDC ( )Tj EMC (\227 \025\230, \204\217\230, \211\003\236 \017)Tj /Span<>> BDC ( )Tj EMC (\007\030. \230\024 \032\036 \f\026\n\024\036 \n\024\032\027\024 )Tj 0.301 Tw T* (\f\022\026\026\021\034 \024\002 \220\n\002\030\017\024\035\024\020\017\004\ \036\f\022\017\b \021\024\027\022\024\f\021\016\b \235\024\030\n\017\030\ \024)Tj 0 Tw (-)Tj 0.126 Tw T* (\r\026\027\017\016 \021\026\024\r\024-\023\030\024\n\036\032\027\024\f\021\ \027\024\020\024 \022\024\n\023\035\036\022\f\026, \023\030\036\007\f\021\ \026\r)Tj 0 Tw (-)Tj 0.122 Tw T* (\035\036\027\027\t\b \r)Tj /Span<>> BDC ( )Tj EMC (\036\007\017\027\017\004\027\t\b \023\031\002\035\017\022\026\006\017\016\ \b [121], \r)Tj /Span<>> BDC ( )Tj EMC (\021\024 \r\030\036\n\016 )Tj 0.104 Tw T* (\022\026\022 \017\n\036\027\027\024 \031\004\036\021 \220\n\002\030\017\024\ \035\024\020\017\004\036\f\022\017\b \007\026\027\027\t\b \027\026\004\017\ \n\024 )Tj 0.515 Tw T* (\031\035\031\004\001\017\035 \030\036\031\035\034\021\026\021\t \030\016\ \007\026 \b\017\030\031\030\020\017\004\036\f\022\017\b \r\n\036\001\026\ )Tj 0 Tw (-)Tj T* (\021\036\035\034\f\021\r \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\007\030\031\020\017\b \026\002\024\035\036\r\026\027\017\016\b [122].)Tj 0.186 Tw T* (\200 2020 \020\024\007\031 \030\026\002\024\004\026\016 \020\030\031\023\ \023\026 \n\036\032\007\031\027\026\030\024\007\027\024\005 \235\036\007\ \036)Tj 0 Tw (-)Tj 0.428 Tw T* (\030\026\006\017\017 \026\022\031\001\036\030\024\r-\020\017\027\036\022\ \024\035\024\020\024\r \(FIGO\) \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\026\027\026\035\017\036 )Tj 0.034 Tw T* (\017\n\036\033\013\017\b\f\016 \007\026\027\027\t\b \024)Tj /Span<>> BDC ( )Tj EMC (\035\036\004\036\027\017\017 \215\217\037 \023\030\017\001\035\026 \022)Tj /Span<>> BDC ( )Tj EMC (\r\t\r\024\007\031, )Tj 0.045 Tw T* (\004\021\024 \021\026\022\021\017\022\026, \023\030\036\007\023\024\035\026\ \020\026\033\013\026\016 \230\003\025\203\230 \002\036 \017\f\023\024\035\ \034\024\r\026)Tj 0 Tw (-)Tj 0.215 Tw T* (\027\017\016 \f\017\027\021\036\021\017\004\036\f\022\017\b \017\n\023\035\ \026\027\021\026\021\024\r, \023\030\036\007\023\024\004\021\017\021\036\ \035\034\027\036\036. )Tj -0.022 Tw T* (\210\007\027\026\022\024 \007\026\027\027\t\b \007\035\016 \024\023\030\036\ \007\036\035\036\027\017\016 \220\021\026\035\024\027\027\024\005 \n\036\ \021\024\007\017\022\017 )Tj 0.022 Tw T* (\b\017\030\031\030\020\017\004\036\f\022\024\020\024 \035\036\004\036\027\ \017\016 \215\217\037 \027\036\007\024\f\021\026\021\024\004\027\024, \017\ )Tj /Span<>> BDC ( )Tj EMC (\r\024\023\030\024\f )Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 0 Tw 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\206)10(\002\036\033 \035\030\032\003\033)30(\n)42(\032)-21(\230\033\241)]TJ 57.136 0 Td (REVIEW)Tj /T1_4 1 Tf 25 0 0 25 505.4521 56.0378 Tm (195)Tj ET endstream endobj 886 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.431 Tw 10 0 0 10 70.8661 724.8299 Tm (\023\030\024\f\021\030\026\027\f\021\r\036 \f\030\026\r\027\017\035\017 \ \026\r\021\024\030\t \007\r\031\b \023\031\002\035\017\022\026\006\017\005\ . )Tj -0.032 Tw 0 -1.218 TD (\200)Tj /Span<>> BDC ( )Tj EMC (\024\007\027\024\n \017\f\f\035\036\007\024\r\026\027\017\017 \017\031\004\ \026\035\f\016 \021\030\026\027\f\023\035\026\027\021\026\021 \017)Tj /Span<>> BDC ( )Tj EMC (\023\024\007)Tj 0 Tw (-)Tj 0.287 Tw T* (\f\035\017\017\f\021\024\005 \024\002\024\035\024\004\022\017 \021\024\027\ \022\024\005 \022\017\001\022\017 \f\r\017\027\034\017, \r)Tj /Span<>> BDC ( )Tj EMC (\007\030\031)Tj 0 Tw (-)Tj 0.426 Tw T* (\020\024\n)Tj /Span<>> BDC ( )Tj EMC (\227 \030\026\035\017\004\027\t\036 \002\017\024\035\024\020\017\004\036\ \f\022\017\036 \021\030\026\027\f\023\035\026\027\021\026\021\t. )Tj 0.068 Tw T* (\210\002\f\035\036\007\024\r\026\027\024 313)Tj /Span<>> BDC ( )Tj EMC (\032\036\027\013\017\027 \f)Tj /Span<>> BDC ( )Tj EMC (\024\002\013\036\005 \023\030\024\007\024\035\032\017\021\036\035\034\027\ \024)Tj 0 Tw (-)Tj -0.067 Tw T* (\f\021\034\033 \027\026\002\035\033\007\036\027\017\016 \024\021 10 \007\ \024)Tj /Span<>> BDC ( )Tj EMC (71 \n\036\f\016\006\036\r \r\024 \r\f\036\b \020\030\031\023\023\026\b. \ )Tj 0.143 Tw 0 -1.218 TD (\202\027\026\021\024\n\017\004\036\f\022\017\036 \024\f\024\002\036\027\027\ \024\f\021\017 \024\006\036\027\017\r\026\035\017 \f)Tj /Span<>> BDC ( )Tj EMC (\017\f\023\024\035\034\024)Tj 0 Tw (-)Tj 0.097 Tw 0 -1.218 TD (\r\026\027\017\036\n \021\024\004\036\022 POP-Q \253Ap\273 \017)Tj /Span<>> BDC ( )Tj EMC (\253Bp\273. \224\023\031\f\021\016 12 \(\007\017\026\023\026)Tj 0 Tw (-)Tj 0.079 Tw T* (\024\027 10\22643\) \n\036\f\016\006\036\r \023\024\f\035\036 \024\023\036\ \030\026\006\017\017 \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \230\003\025\203\230 )Tj 0.022 Tw T* (\002\t\035\024 6)Tj /Span<>> BDC ( )Tj EMC (\(9%\) \017)Tj /Span<>> BDC ( )Tj EMC (70 \023\026\006\017\036\027\021\024\022, \f)Tj /Span<>> BDC ( )Tj EMC (\007\017\f\021\026\027\006\017\036\005 \253\202\030\273 \017\035\017 )Tj 0.072 Tw T* (\253\200\030\273 \002\024\035\034\001\036 \017\035\017 \030\026\r\027\024\ \005 1)Tj /Span<>> BDC ( )Tj EMC (\f\n, \023\030\024\021\017\r 8)Tj /Span<>> BDC ( )Tj EMC (\(12%\) \017)Tj /Span<>> BDC ( )Tj EMC (67 )Tj 0.001 Tw T* (\023\030\017)Tj /Span<>> BDC ( )Tj EMC (\017\f\023\024\035\034\024\r\026\027\017\017 \021\030\026\027\f\023\035\ \026\027\021\026\021\026, \030\026\027\017\006\026 \f\021\026\021\017\f\ \021\017)Tj 0 Tw (-)Tj 0 -1.218 TD [(\004\036\f\022\017 \027\036 \027\026\004\017\n\026 [116]. G)20(r)-37(imes)]TJ /Span<>> BDC ( )Tj EMC (C. \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. \023\030\024\007\036\n\024\027)Tj (-)Tj 0.112 Tw 0 -1.218 TD (\f\021\030\017\030\024\r\026\035\017, \004\021\024 120)Tj /Span<>> BDC ( )Tj EMC (\(97%\) \017)Tj /Span<>> BDC ( )Tj EMC (124)Tj /Span<>> BDC ( )Tj EMC (\032\036\027\013\017\027 \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 )Tj 0.101 Tw 0 -1.218 TD (\230\003\025\203\230 \023\024)Tj /Span<>> BDC ( )Tj EMC (\f\030\026\r\027\036\027\017\033 \f)Tj /Span<>> BDC ( )Tj EMC (67)Tj /Span<>> BDC ( )Tj EMC (\(97%\) \017)Tj /Span<>> BDC ( )Tj EMC (69 \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036, \020\007\036 )Tj 0.385 Tw T* (\023\030\017\n\036\027\016\035\f\016 \021\030\026\027\f\023\035\026\027\021\ \026\021, \017\n\036\035\017 \007\017\f\021\026\027\006\017\033 \253Bp\273\ )Tj 0.046 Tw T* (\002\024\035\034\001\036 \017\035\017 \030\026\r\027\031\033 0 [16]. \203\ \036 \002\t\035\024 \030\026\035\017\004\017\005 \n\036\032\007\031 )Tj 0.193 Tw T* (\020\030\031\023\023\026\n\017 \023\024)Tj /Span<>> BDC ( )Tj EMC (\f\021\026\007\017\017 \023\030\024\035\026\023\f\026 \003\224\200 \r)Tj /Span<>> BDC ( )Tj EMC (\024\002\036\017\b \020\030\031\023\023\026\b )Tj 0.079 Tw T* ([79]. \203\036 \002\t\035\024 \r\t\016\r\035\036\027\024 \030\026\027\017\ \006\t \r)Tj /Span<>> BDC ( )Tj EMC (\023\024\007\021\r\036\030\032\007\036\027\027\t\b )Tj 0.073 Tw T* [(\007\036\235\036\022\026\006\017\024\027\027\t\b )0.5(\f\017\n\023\021\024\n\026\b \n\036\032\007\031 \007\r\031\n\016 \023\024\ \007\b\024\007\026\n\017. )]TJ 0.179 Tw T* (\215\024\f\035\036 \024\023\036\030\026\006\017\017 \004\026\f\021\024\021\ \026 \224\210\212 \r)Tj /Span<>> BDC ( )Tj EMC (\220\021\017\b \017\f\f\035\036\007\024\r\026\027\017\016\b )Tj -0.007 Tw T* (\r\026\030\034\017\030\024\r\026\035\026\f\034 \024\021 3 \007\024)Tj /Span<>> BDC ( )Tj EMC (7%. \025\030\024\n\036 \021\024\020\024, \027\036 \002\t\035\024 \r\t\016\ \r)Tj 0 Tw (-)Tj -0.034 Tw T* [(\035\036\027\024 \030\026\035\017\004\017\005 \027\017 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC [(\031\007\024\r\035\036\021\r\024\030\036\027\027\024\f\021\017 )0.5(\023\026\006\017\036\027\021\024\r, )0.5(\027\017 )]TJ 0.104 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\027\036\032\036\035\026\021\036\035\034\027\t\b \016\r\035\036\027\017\016\ \b, \r\022\035\033\004\026\016 \021\030\026\r\n\t \023\030\016\n\024\005\ )Tj -0.013 Tw T* [(\022\017\001\022\017, \n\024\004\036\r\024\020\024 \023\031\t\030\016, \ )0.5(\030\026\027\036\r\t\036 \017\027\235\036\022\006\017\017 )0.5(\017\035\017 \007\017\f)]TJ 0 Tw (-)Tj -0.021 Tw T* (\023\026\030\036\031\027\017\033. \224\024\024\002\013\026\035\024\f\034\ \024\002 \220\030\024\017\017, \f\r\016\026\027\027\024\005 \f)Tj /Span<>> BDC ( )Tj EMC (\021\030\026\027\f)Tj 0 Tw (-)Tj 0.138 Tw T* (\023\035\026\027\021\026\021\024\n)Tj /Span<>> BDC ( )Tj EMC (\227 1 \f\035\031\004\026\005 \017)Tj /Span<>> BDC ( )Tj EMC (69, \002\024\035\034\001\036\005 \022\030\024\r\024\023\024\021\036\030\036\ )Tj 0 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \021\030\026\027\f\023\035\026\027\021\026\021\026\ .)Tj 0.212 Tw T* (\236\f\023\024\035\034\024\r\026\027\017\036 \021\030\026\027\f\023\035\ \026\027\021\026\021\026 \027\036 \023\030\017\r\036\035\024 \022)Tj /Span<>> BDC ( )Tj EMC (\027\026\004\017)Tj 0 Tw (-)Tj 0.011 Tw T* (\021\036\035\034\027\024\n\031 \031\035\031\004\001\036\027\017\033 \f\021\ \030\031\022\021\031\030\t \003\224\200 \017\035\017 \031\n\036\027\034\001\ \036\027\017\033 )Tj 0.161 Tw T* [(\224\210\212, )0.5(\026)]TJ /Span<>> BDC ( )Tj EMC 3.054 0 Td [(\021\026\022\032\036 )0.5(\022)]TJ /Span<>> BDC ( )Tj EMC 3.677 0 Td [(\027\026\004\017\021\036\035\034\027\024\005 )0.6(\030\026\027\017\006\036 )0.6(\r)]TJ /Span<>> BDC ( )Tj EMC 10.73 0 Td (\022\024\035\017\004\036\f\021\r\036 )Tj 0 Tw -17.461 -1.218 Td (\027\036\032\036\035\026\021\036\035\034\027\t\b \016\r\035\036\027\017\005\ .)Tj 0.268 Tw T* (\236\f\f\035\036\007\024\r\026\021\036\035\017 \f\b\024\007\016\021\f\016\ \r\024 \n\027\036\027\017\017, \004\021\024 \017\f\023\024\035\034\024\ )Tj 0 Tw (-)Tj 0.537 Tw T* (\r\026\027\017\036 \f\017\027\021\036\021\017\004\036\f\022\017\b \017\n\ \023\035\026\027\021\026\021\024\r \f\027\017\032\026\036\021 \030\017\f\ \022 )Tj 0.208 Tw T* [(\030\026\r\017\021\017\016 )0.5(\030\036\006\017\007\017\r\026. )0.5(\200)]TJ /Span<>> BDC ( )Tj EMC 9.862 0 Td [(\021\024 )0.5(\032\036 )0.5(\r\030\036\n\016 )0.5(\017\b )0.5(\023\030\017\n\036\027\036\027\017\036 )]TJ 0.128 Tw -9.862 -1.218 Td (\r)Tj /Span<>> BDC ( )Tj EMC [(20% \f\035\031\004\026\036\r )0.5(\023\030\017\r\024\007\017\021 \022)]TJ /Span<>> BDC ( )Tj EMC [(\030\016\007\031 \024\f\035\024\032\027\036\027\017\005 )0.5(\(Mesh-)]TJ 0.481 Tw T* [(\026\f\f\024\006\017\017\030\024\r\026\027\027\t\b\), )0.6(\027\026\004\017\n\024 )0.6(\f\027\017\032\026\033\013\017\b )0.5(\022\026\004\036\f\021\r\024 )]TJ 0.15 Tw T* (\032\017\027\017 \023\026\006\017\036\027\021\024\022. \025)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\017\n \024\f\035\024\032\027\036\027\017\016\n \024\021\027\ \024\f\016\021\f\016: )Tj 0.102 Tw T* (\220\030\024\017\017, \017\027\235\017\006\017\030\024\r\026\027\017\036\ , \220\022\f\021\030\031\017\016 \017\n\023\035\026\027\021\026\021\026\ , \023\036\030)Tj 0 Tw (-)Tj 0.074 Tw T* (\235\024\030\026\006\017\016 \f\024\f\036\007\027\017\b \024\030\020\026\ \027\024\r, \024\013\031\013\036\027\017\036 \007\017\f\022\024\n\235\024\ \030\021\026, )Tj 0.228 Tw T* (\002\024\035\017, \020\036\n\026\021\024\n\t \017)Tj /Span<>> BDC ( )Tj EMC (\f\027\017\032\036\027\017\036 \f\036\022\f\031\026\035\034\027\024\005 \ \235\031\027\022\006\017\017. )Tj 0.032 Tw T* [(\215\024\023\024\r \202.\202. )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC [(\f\024\026\r\021. )0.5(\024\023\031\002\035\017\022\024\r\026\035\017 \030\036\031\035\034\021\ \026\021\t )0.5(\f\r\024\036\020\024 )]TJ 0.252 Tw T* (\017\f\f\035\036\007\024\r\026\027\017\016, \007\036\022\035\026\030\017\ \030\031\016, \004\021\024 \b\017\030\031\030\020\017\004\036\f\022\026\016\ \022\024\030)Tj 0 Tw (-)Tj 0.188 Tw T* (\030\036\022\006\017\016 \023\030\024\035\026\023\f\026 \f)Tj /Span<>> BDC ( )Tj EMC (\017\f\023\024\035\034\024\r\026\027\017\036\n \f\017\027\021\036\021\017\ \004\036\f\022\024\020\024 )Tj 0.078 Tw T* (\017\n\023\035\026\027\021\026\021\026 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\215\230\210 \002\t\035\026 \023\030\036\007\023\024\004\021\017\021\036\ \035\034\027\026 \027\026)Tj /Span<>> BDC ( )Tj EMC (\023\024\007)Tj 0 Tw (-)Tj T* (\027\017\b, \030\036\006\017\007\017\r\017\030\031\033\013\017\b \f\021\026\ \007\017\016\b \026\002\024\035\036\r\026\027\017\016 [71].)Tj 0.035 Tw T* (\212\035\016 \032\036\027\013\017\027 \032\036 \217\200, \f)Tj /Span<>> BDC ( )Tj EMC (\006\036\035\034\033 \f\024\b\030\026\027\036\027\017\016 \f\036\022\f\031\ \026\035\034\027\024\005 )Tj 0.209 Tw T* (\235\031\027\022\006\017\017, \006\036\035\036\f\024\024\002\030\026\027\ \036\036 \022\024\030\030\036\022\006\017\016 \215\230\210 \027\026\021\017\ \r\027\t)Tj 0 Tw (-)Tj 0.512 Tw T* (\n\017 \021\022\026\027\016\n\017 [70,72,73,78]. Mesh-\026\f\f\024\006\017\ \017\030\024\r\026\027\027\t\036 )Tj 0.288 Tw T* (\024\f\035\024\032\027\036\027\017\016 \r\f\021\030\036\004\026\033\021\f\ \016 \004\026\013\036 \031)Tj /Span<>> BDC ( )Tj EMC (\032\036\027\013\017\027 \f\021\026\030\001\036\005 )Tj 0.095 Tw T* (\r\024\030\026\f\021\027\024\005 \020\030\031\023\023\t. \202\r\021\024\ \030\t \f\r\016\t\r\026\033\021 \007\026\027\027\t\005 \235\026\022\021\ )Tj 0.117 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\031\n\036\027\034\001\036\027\017\036\n \r\026\f\022\031\035\016\030\017\ \026\006\017\017 \n\026\035\024\020\024 \021\026\026 \r)Tj /Span<>> BDC ( )Tj EMC (\023\024\f\021)Tj 0 Tw (-)Tj 0.242 Tw T* (\n\036\027\024\023\026\031\026\035\034\027\024\n \023\036\030\017\024\007\ \036. \200\t\f\024\022\024\005 \004\026\f\021\024\021\024\005 Mesh-)Tj 1.16 Tw T* (\026\f\f\024\006\017\017\030\024\r\026\027\027\t\b \024\f\035\024\032\027\ \036\027\017\005 \b\026\030\026\022\021\036\030\017\031\036\021\f\016 )Tj 0.267 Tw 23.244 64.543 Td (\021\030\024\026\022\026\030\027\026\016 \n\036\021\024\007\017\022\026 \ \235\017\022\f\026\006\017\017 \f\017\027\021\036\021\017\004\036\f\022\017\ \b \017\n)Tj 0 Tw (-)Tj T* (\023\035\026\027\021\026\021\024\r [75].)Tj 0.184 Tw T* (\200 \023\036\030\r\024\005 \007\036\022\026\007\036 21-\020\024 \r\036\022\ \026 \024\023\031\002\035\017\022\024\r\026\027\t \030\016\007 \017\f)Tj 0 Tw (-)Tj 0.23 Tw T* [(\f\035\036\007\024\r\026\027\017\005 )0.5(\030\036\031\035\034\021\026\021\024\r )0.6(\017\f\023\024\035\034\024\r\026\027\017\016 )0.6(\002\017\024\035\024\020\017\004\036)]TJ 0 Tw (-)Tj 0.202 Tw T* (\f\022\017 \021\030\026\027\f\023\035\026\027\021\026\021\024\r. \202\027\ \026\021\024\n\017\004\036\f\022\017\036 \030\036\031\035\034\021\026\021\ \t \017\f)Tj 0 Tw (-)Tj -0.018 Tw T* [(\023\024\035\034\024\r\026\027\017\016 )0.6(\002\017\024\035\024\020\017\004\036\f\022\017\b )0.5(\017\n\023\035\026\027\021\026\021\024\r )0.5(\007\024\f\021\024\r\036\030\027\024 )]TJ 0.107 Tw 0 -1.218 TD (\b\031\032\036 \023\035\026\f\021\017\022\017 \027\026\021\017\r\027\t\n\ \017 \021\022\026\027\016\n\017. \215\024\f\035\036 \220\021\017\b \023\031\ \002)Tj /Span<>> BDC (-)Tj EMC 0.143 Tw 0 -1.218 TD (\035\017\022\026\006\017\005 \017\027\021\036\030\036\f \022)Tj /Span<>> BDC ( )Tj EMC (\017\f\023\024\035\034\024\r\026\027\017\033 \002\017\024\021\030\026\027\ \f\023\035\026\027\021\026)Tj 0 Tw (-)Tj T* (\021\024\r \031\020\026\f [74,117].)Tj /T1_1 1 Tf 0.252 Tw 0 -2.436 TD (\031\201\020\235\007\210\007\217\002\002\020\215 \020\235\002\215\215 \004\ \217\001\203\204\217\201\201\020\214\007\215 \002\020\b\007\206\002\240\207\ \007 )Tj 0.277 Tw 0 -1.218 TD [(\b\004\020\002\215\207\007 )0.5(\206)]TJ /Span<>> BDC ( )Tj EMC 5.453 0 Td [(\017\201\020\206\002\005\002\007\007 )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC 5.939 0 Td [(\202\017\b\201\020\002\005\002\007\005\207 )0.6(\235\005\214\005\004\b\217\206 )]TJ 0 Tw -11.392 -1.218 Td (\206)Tj /Span<>> BDC ( )Tj EMC (\020\206\007\017\007\207\217\017\b\007 \217\b \001\217\004\020\001\007\ \020\210\007\007)Tj /T1_0 1 Tf 0.14 Tw 0 -1.218 TD (\200)Tj /Span<>> BDC ( )Tj EMC [(\017\f\f\035\036\007\024\r\026\027\017\017 A)-14(br)-33(amov Y. \017)]TJ /Span<>> BDC ( )Tj EMC (\f\024\026\r\021., \030\036\021\030\024\f\023\036\022\021\017\r)Tj 0 Tw (-)Tj 0.082 Tw 0 -1.218 TD (\027\024 \f\030\026\r\027\017\r\026\035\017\f\034 \220\235\235\036\022\021\ \t \230\003\025\203\230 \017)Tj /Span<>> BDC ( )Tj EMC (\204\037\211\212 \r)Tj /Span<>> BDC ( )Tj EMC (\024\023\024\030\027\t\b )Tj 0.124 Tw T* (\f\021\030\031\022\021\031\030\026\b \(302 \023\026\006\017\036\027\021\026\ \) [72,118]. \232\036\030\036 12 \n\036\f\016)Tj 0 Tw (-)Tj -0.013 Tw T* (\006\036\r \230\003\025\203\230 \023\030\036\r\024\f\b\024\007\017\035\026\ \204\037\211\212 \023\024)Tj /Span<>> BDC ( )Tj EMC (\026\027\026\021\024\n\017\004\036\f\022\017\n \030\036)Tj 0 Tw (-)Tj -0.033 Tw T* (\031\035\034\021\026\021\026\n, \024\006\036\027\036\027\027\t\n \023\024\ )Tj /Span<>> BDC ( )Tj EMC [(\001\022\026\035\036 Baden\226W)12(alk)10(er \017)]TJ /Span<>> BDC ( )Tj EMC (\021\024\004\022\036 )Tj 0.1 Tw T* [(\253Bp\273 POP-Q )0.5(\(\2312,7 \023\030\024\021\017\r \2312,2)]TJ /Span<>> BDC ( )Tj EMC (\f\n, )Tj /T1_2 1 Tf 0 Tw (p)Tj /T1_0 1 Tf 0.1 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC 15.941 0 Td (0,001\), \004\026\f\021\024\021\036 )Tj -0.057 Tw -15.941 -1.218 Td (\030\036\006\017\007\017\r\024\r \022\026\022 \026)Tj /Span<>> BDC ( )Tj EMC (\f\030\036\007\027\036\r\035\026\020\026\035\017\013\027\024\005 \023\035\ \024\f\022\024\f\021\034\033 \(14 )Tj -0.023 Tw T* (\023\030\024\021\017\r 33%, )Tj /T1_2 1 Tf 0 Tw (p)Tj /T1_0 1 Tf -0.023 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,001\), \021\026\022 \017)Tj /Span<>> BDC ( )Tj EMC (\026 \020\017\n\036\027\026\035\034\027\t\n \022\024\035\034\006\024\n \ )Tj 0.136 Tw T* (\(4)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\021\017\r 11%, )Tj /T1_2 1 Tf 0 Tw (p)Tj /T1_0 1 Tf 0.136 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,02\). \215\024)Tj /Span<>> BDC ( )Tj EMC (\f\031\002\255\036\022\021\017\r\027\t\n \023\024\022\026\026)Tj 0 Tw (-)Tj 0.056 Tw T* (\021\036\035\016\n \230\003\025\203\230 \021\026\022\032\036 \023\030\036\ \r\024\f\b\024\007\017\035\026 \023\024)Tj /Span<>> BDC ( )Tj EMC (\022\026\004\036\f\021\r\031 \204\037\211\212. )Tj 0.271 Tw T* (\232\021\024 \022\026\f\026\036\021\f\016 \f\017\n\023\021\024\n\027\024\ \020\024 \023\030\024\035\026\023\f\026 \f\021\036\027\024\022 \r\035\026\ \020\026)Tj 0 Tw (-)Tj 0.122 Tw T* (\035\017\013\026, \021\024 \230\003\025\203\230 \017\n\036\035\026 \f\021\ \026\021\017\f\021\017\004\036\f\022\017 \027\026\004\017\n\024 \002\024\ \035\036\036 )Tj 0.014 Tw T* (\027\017\022\031\033 \f\031\002\255\036\022\021\017\r\027\031\033 \004\026\ \f\021\024\021\031 \030\036\006\017\007\017\r\024\r \(4% \023\030\024\021\ \017\r )Tj 0 Tw T* (11%, )Tj /T1_2 1 Tf 2.232 0 Td (p)Tj /T1_0 1 Tf 0.055 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,02\). \203\017 \024\007\027\026 \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\006\036\007\031\030 \f\031\013\036\f\021\r\036\027\027\024 \ \027\036 )Tj 0.472 Tw -2.232 -1.218 Td [(\031\n\036\027\034\001\017\035\026 )0.6(\004\026\f\021\024\021\031 )0.5(\022\024\027\f\021\017\023\026\006\017\017. )0.6(\212\036\235\036\022\026\006\017\024\027\027\t\036 )]TJ 0.315 Tw T* (\f\017\n\023\021\024\n\t \027\036 \017\031\004\026\035\017\f\034. \217\026\ \027\017\006\t \023\024)Tj /Span<>> BDC ( )Tj EMC (\022\030\024\r\024\023\024\021\036\030\036 )Tj 0.105 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\017\024\023\036\030\026\006\017\024\027\027\t\n \024\f\035\024\ \032\027\036\027\017\016\n, \r\022\035\033\004\026\016 \022\030\024\r\024\ )Tj 0 Tw (-)Tj 0.138 Tw T* (\021\036\004\036\027\017\036, \030\026\027\036\r\031\033 \017\027\235\036\ \022\006\017\033, \027\036 \002\t\035\024. \232\026\f\021\024\021\026 \007\ \017\f)Tj 0 Tw (-)Tj T* (\023\026\030\036\031\027\017\017 )Tj /T1_2 1 Tf 0.007 Tw 4.165 0 Td [(de nov)13(o)]TJ /T1_0 1 Tf ( \002\t\035\026 \024\007\017\027\026\022\024\r\024\005 \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\f\021\026\r\017\035\026 11%. )Tj 0.225 Tw -4.165 -1.218 Td (\211\007\024\r\035\036\021\r\024\030\036\027\027\024\f\021\034 \023\026\006\ \017\036\027\021\024\022 \027\036 \017\031\004\026\035\026\f\034. \230\003\ \025\203\230 )Tj 0.155 Tw T* (\023\030\024\007\036\n\024\027\f\021\030\017\030\024\r\026\035\026 \035\031\ \004\001\036\036 \r\024\f\f\021\026\027\024\r\035\036\027\017\036 \f\021\ \030\031\022)Tj 0 Tw (-)Tj 0.04 Tw T* (\021\031\030\t \003\224\200 \017)Tj /Span<>> BDC ( )Tj EMC (\f\027\017\032\036\027\017\036 \004\026\f\021\024\021\t \017)Tj /Span<>> BDC ( )Tj EMC (\r\t\030\026\032\036\027\027\024\f\021\017 \f\017\n\023)Tj 0 Tw (-)Tj T* (\021\024\n\024\r, \023\024)Tj /Span<>> BDC ( )Tj EMC (\f\030\026\r\027\036\027\017\033 \f)Tj /Span<>> BDC ( )Tj EMC (\204\037\211\212.)Tj /T1_1 1 Tf 0.252 Tw 0 -2.436 TD (\031\201\020\235\007\210\007\217\002\002\020\215 \020\235\002\215\215 \004\ \217\001\203\204\217\201\201\020\214\007\215 \002\020\b\007\206\002\240\207\ \007 )Tj 0.03 Tw 0 -1.218 TD (\b\004\020\002\215\207\007 \206)Tj /Span<>> BDC ( )Tj EMC (\017\201\020\206\002\005\002\007\007 \017)Tj /Span<>> BDC ( )Tj EMC (\b\201\020\002\017\020\002\020\001\203\002\240\207 \235\217\017\b\202\204\ \217\207 )Tj 0 Tw T* (\004\217\201\201\005\004\210\007\007 \201\005\004\b\217\210\005\001\005)Tj /T1_0 1 Tf 0.583 Tw T* [(\230\003\025\203\230 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 4.654 0 Td [(\f\030\026\r\027\036\027\017\017 )0.6(\f)]TJ /Span<>> BDC ( )Tj EMC 6.469 0 Td [(\021\030\026\027\f\026\027\026\035\034\027\t\n )0.6(\007\024\f\021\031\023\024\n )]TJ 0.517 Tw -11.123 -1.218 Td [(\022\024\030\030\036\022\006\017\017 )0.5(\215\217\037 )0.6(\024\006\036\027\017\r\026\035\026\f\034 )0.6(\r)]TJ /Span<>> BDC ( )Tj EMC 14.885 0 Td [(\007\r\031\b )0.5(\017\f\f\035\036\007\024\r\026)]TJ 0 Tw (-)Tj 0.263 Tw -14.885 -1.218 Td (\027\017\016\b [30,31], \f)Tj /Span<>> BDC ( )Tj EMC (\024\002\013\017\n \022\024\035\017\004\036\f\021\r\024\n 78 \023\026\006\ \017\036\027\021\024\r. )Tj 0.052 Tw T* (Nieminen \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. [119] \024\006\036\027\017\035\017 30 \023\026\006\017\ \036\027\021\024\022 \017)Tj /Span<>> BDC ( )Tj EMC (\024\002)Tj 0 Tw (-)Tj 0.059 Tw T* [(\027\026\030\031\032\017\035\017, )0.5(\004\021\024 \230\003\025\203\230 )0.5(\026\f\f\024\006\017\017\030\024\r\026\027\026 )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC [(\035\031\004\001\017\n\017 )0.5(\026\027\026)]TJ 0 Tw (-)Tj 0.221 Tw T* (\021\024\n\017\004\036\f\022\017\n\017 \030\036\031\035\034\021\026\021\ \026\n\017, \017\n\036\030\036\027\027\t\n\017 \023\024)Tj /Span<>> BDC ( )Tj EMC (POP-Q )Tj 0.099 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\021\024\004\022\036 \253Ap\273 \(\2312,8)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (0,56 \f\n \023\030\024\021\017\r \2311,36)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (1,12 \f\n, )Tj /T1_2 1 Tf 0 Tw T* (p)Tj /T1_0 1 Tf 0.039 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,01\), \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\022\035\017\027\017\004\036\f\022\024\n \024\f\n\024\021\030\036 \(7% \023\ \030\024\021\017\r 40%, )Tj /T1_2 1 Tf 0 Tw T* (p)Tj /T1_0 1 Tf 0.271 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,04\), \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\017 \007\036\235\036\022\024\020\030\026\235\017\017 \004\036\030\ \036 12 \n\036\f\016\006\036\r )Tj 0.01 Tw T* (\(\f)Tj /Span<>> BDC ( )Tj EMC (6,00)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (1,6 \007\024)Tj /Span<>> BDC ( )Tj EMC (2,73)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (1,87, )Tj /T1_2 1 Tf 0 Tw (p)Tj /T1_0 1 Tf 0.01 Tw /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (0,0001 \017)Tj /Span<>> BDC ( )Tj EMC (\f 5,60)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (1,8)Tj /Span<>> BDC ( )Tj EMC (\f\n )Tj 0.011 Tw T* (\007\024)Tj /Span<>> BDC ( )Tj EMC (4,13)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (2,10 \f\n, )Tj /T1_2 1 Tf 0 Tw (p)Tj /T1_0 1 Tf 0.011 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC [(0,07\). \210\007\027\026\022\024 F)20(ar)-36.9(id \017)]TJ /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. [96] )Tj 0.079 Tw T* (\023\030\017)Tj /Span<>> BDC ( )Tj EMC (\007\036\235\036\022\024\020\030\026\235\017\017 \031)Tj /Span<>> BDC ( )Tj EMC (48 \023\026\006\017\036\027\021\024\022 \r\t\016\r\017\035\017 \031\035\031\ \004\001\036)Tj 0 Tw (-)Tj 0.012 Tw T* (\027\017\036 \023\024)Tj /Span<>> BDC ( )Tj EMC (\f\030\026\r\027\036\027\017\033 \f)Tj /Span<>> BDC ( )Tj EMC (\017\f\b\024\007\027\t\n\017 \023\024\022\026\026\021\036\035\016\n\017\ , \027\024 \002\036 )Tj 0.247 Tw T* [(\f\021\026\021\017\f\021\017\004\036\f\022\017 \027\026\004\017\n\024\005\ )0.5(\030\026\027\017\006\t \n\036\032\007\031 \020\030\031\023\023\026\n\017\ . )]TJ 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0 Tw 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\206)10(\002\036\033 \035\030\032\003\033)30(\n)42(\032)-21(\230\033\241)]TJ 57.136 0 Td (REVIEW)Tj -57.136 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 2)69(4, \023\0224, 202)23(5)]TJ 43.013 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 2)69(4, \023\0224, 202)23(5)]TJ /T1_4 1 Tf 25 0 0 25 20.8652 56.0378 Tm (194)Tj ET endstream endobj 885 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\033\016\017)-10(\026)11(\025\212\016\t\016 \200\022\216\016\215\232\021\215: \215\016\201\016\020\ \016\215\215\220\016 \r\025\222\201\025\b\220 \(\025\235\213\025\201\022\ \t\021\026)11(\016\201\001\026)-20(\200\201\220\))]TJ 41.66 0 Td [(Rectocele in females: unr)31(esolv)12(ed issues \(r)31(e)11(vie)11(w\))]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 10 0 0 10 42.5197 724.8299 Tm (\031\201\020\002\017\020\002\020\001\203\002\240\003 \235\217\017\b\202\204\ \235\001\215 \004\217\201\201\005\004\210\007\007 \201\005\004\b\217\210\ \005\001\005)Tj /T1_2 1 Tf 0.433 Tw 0 -1.218 TD (\211\f\021\030\026\027\036\027\017\036 \215\217\037 \021\030\026\027\f\026\ \027\026\035\034\027\t\n \007\024\f\021\031\023\024\n \024\006\036\027\036\ )Tj 0 Tw (-)Tj 0.104 Tw T* (\027\024 \r)Tj /Span<>> BDC ( )Tj EMC (4 \017\f\f\035\036\007\024\r\026\027\017\016\b, \r)Tj /Span<>> BDC ( )Tj EMC (\022\024\021\024\030\t\b 153 \023\026\006\017\036\027\021\022\017 \027\026\ )Tj 0 Tw (-)Tj 0.234 Tw T* (\002\035\033\007\026\035\017\f\034 6\22625)Tj /Span<>> BDC ( )Tj EMC (\n\036\f\016\006\036\r. \200)Tj /Span<>> BDC ( )Tj EMC (\006\036\035\024\n, \021\030\026\027\f\026\027\026\035\034\027\t\005 )Tj 0.233 Tw T* (\023\024\007\b\024\007 \031\035\031\004\001\017\035 \f\021\030\031\022\021\ \031\030\031 \003\224\200 \017)Tj /Span<>> BDC ( )Tj EMC (\031\n\036\027\034\001\017\035 \023\030\024\016\r)Tj 0 Tw (-)Tj 0.205 Tw T* (\035\036\027\017\016 \224\210\212 [92\22695]. \215\030\024\016\r\035\036\ \027\017\016 \215\217\037, \r\t\016\r\035\036\027\027\024\020\024 )Tj 0.307 Tw 0 -1.218 TD (\023\030\017)Tj /Span<>> BDC ( )Tj EMC (\007\036\235\036\022\024\020\030\026\235\017\017, \f\027\017\017\035\017\ \f\034 \023\024\f\035\036 \024\023\036\030\026\006\017\017 \r\024 )Tj 0.197 Tw 0 -1.218 TD (\r\f\036\b 4 \017\f\f\035\036\007\024\r\026\027\017\016\b. \025\030\024\n\ \036 \021\024\020\024, \r)Tj /Span<>> BDC ( )Tj EMC (\024\007\027\024\n \017\f\f\035\036)Tj 0 Tw (-)Tj 0.262 Tw T* (\007\024\r\026\027\017\017 \023\024\022\026\026\027\024 \031\n\036\027\034\ \001\036\027\017\036 \r\t\030\026\032\036\027\027\024\f\021\017 \215\217\ \037 )Tj 0.267 Tw T* (\f\024\020\035\026\f\027\024 \f\017\f\021\036\n\036 POP-Q \023\024)Tj /Span<>> BDC ( )Tj EMC (\021\024\004\022\036 \253Ap\273. \215\026\006\017\036\027\021\t )Tj 0.128 Tw T* (\f\024\024\002\013\026\035\017 \024\002 \031\035\031\004\001\036\027\017\ \017 \r)Tj /Span<>> BDC ( )Tj EMC (\024\021\027\024\001\036\027\017\017 \224\210\212, \r\022\035\033\004\026\ \016 )Tj 0.109 Tw T* (\017\f\023\024\035\034\024\r\026\027\017\036 \023\026\035\034\006\036\r\ \024\020\024 \023\024\f\024\002\017\016 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\007\036\235\036\022\026\006\017\017. )Tj -0.002 Tw 0 -1.218 TD (\203\036\032\036\035\026\021\036\035\034\027\t\n\017 \016\r\035\036\027\017\ \016\n\017 \002\t\035\017 \030\026\027\036\r\026\016 \017\027\235\036\022\ \006\017\016 )Tj 0.059 Tw 0 -1.218 TD (\(2,2\2266,7%\) \017)Tj /Span<>> BDC ( )Tj EMC (\007\017\f\023\026\030\036\031\027\017\016 \023\024\f\035\036 \f\017\n\031\ \035\034\021\026\027\027\024\005 \035\036\r\026)Tj 0 Tw (-)Tj 0 -1.218 TD (\021\024\030\024\023\035\026\f\021\017\022\017 \(29%\).)Tj 0.064 Tw T* (\230\030\026\027\f\026\027\026\035\034\027\t\005 \007\024\f\021\031\023 \ \f\024\023\030\016\032\036\027 \f)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\036\036 \n\026\f\f\017\r\027\t\n )Tj 0.157 Tw T* [(\022\030\024\r\024\021\036\004\036\027\017\036\n )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC 7.585 0 Td [(\024\023\026\f\027\024\f\021\034\033 )0.6(\030\026\r\017\021\017\016 )0.5(\020\027\024\005\027\t\b )0.6(\024\f)]TJ 0 Tw (-)Tj 0.435 Tw -7.585 -1.218 Td (\035\024\032\027\036\027\017\005, \024\007\027\026\022\024 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\027\036\024\002\b\024\007\017\n\024\f\021\017 \017\f\f\036\004\036\027\017\ \016 )Tj 0.211 Tw T* (\f\035\017\017\f\021\024\005 \024\002\024\035\024\004\022\017 \023\030\016\ \n\024\005 \022\017\001\022\017, \007\026\027\027\t\005 \007\024\f\021\031\ \023 )Tj 0 Tw T* (\n\024\032\036\021 \002\t\021\034 \023\030\036\007\023\024\004\021\017\021\ \036\035\034\027\t\n [96].)Tj 0.315 Tw T* (\210\021\036\004\036\f\021\r\036\027\027\t\005 \024\023\t\021 \b\017\030\ \031\030\020\017\004\036\f\022\024\020\024 \035\036\004\036\027\017\016 \ \030\036\022)Tj 0 Tw (-)Tj 0.15 Tw T* (\021\024\006\036\035\036 \r)Tj /Span<>> BDC ( )Tj EMC (\f\024\004\036\021\026\027\017\017 \f)Tj /Span<>> BDC ( )Tj EMC (\027\017\022\024\005 \017\027\r\026\020\017\027\026\006\017\036\005 \023\ \030\016\n\024\005 )Tj 0.48 Tw T* (\022\017\001\022\017 \023\024)Tj /Span<>> BDC ( )Tj EMC (\n\036\021\024\007\031 \021\030\026\027\f\026\027\026\035\034\027\024\005\ \023\030\024\022\021\024\023\035\026\f\021\017\022\017 )Tj 0.02 Tw T* (\(\024\023\036\030\026\006\017\016 \202. \214\024\027\020\024\) \f\r\017\ \007\036\021\036\035\034\f\021\r\031\036\021 \024\002 \031\n\036\027\034\ \001\036\027\017\017 )Tj -0.041 Tw T* (\023\030\024\016\r\035\036\027\017\005 \224\210\212 \031)Tj /Span<>> BDC ( )Tj EMC (20)Tj /Span<>> BDC ( )Tj EMC (\(65%\) \017)Tj /Span<>> BDC ( )Tj EMC (31 \023\030\024\024\023\036\030\017\030\024\r\026\027\027\024\020\024 )Tj -0.03 Tw T* (\023\026\006\017\036\027\021\026 \(\027\026 \024\f\027\024\r\036 \024\030\ \017\020\017\027\026\035\034\027\024\005 \001\022\026\035\t-\024\023\030\ \024\f\027\017\022\026 )Tj 0.077 Tw T* (\203\204\236\037 \022\024\035\024\023\030\024\022\021\024\035\024\020\017\ \017 \204\017\027\007\030\026\r\026 \217\024\f\f\017\017\), \026)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\032\036 )Tj 0 Tw T* (\024\002 \031\035\031\004\001\036\027\017\017 \022\026\004\036\f\021\r\026\ \032\017\027\017 [97].)Tj /T1_1 1 Tf 0.731 Tw 0 -2.436 TD [(\026\b\005\204\001\005\201\002\020\215 )0.6(\b\201\020\002\017\020\002\020\001\203\002\020\215 )0.6(\201\005\005\004\210\007\215 )0.5(\204\201\215\207\217\003 )]TJ 0 Tw 0 -1.218 TD (\004\007\221\004\007)Tj /T1_2 1 Tf 0.217 Tw T* (\224\021\036\023\035\036\030\027\026\016 \021\030\026\027\f\026\027\026\035\ \034\027\026\016 \030\036\036\022\006\017\016 \023\030\016\n\024\005 \022\ \017\001\022\017 )Tj 0.192 Tw T* [(\(S)-21(T)35(ARR\) )0.5(\023\030\036\007\023\024\035\026\020\026\036\021 )0.5(\017\f\023\024\035\034\024\r\026\027\017\036 )0.5(\006\017\030\022\031\035\016\030\027\024\020\024 )]TJ 0.641 Tw T* (\f\021\036\023\035\036\030\026-\026\027\024\f\022\024\023\026, \023\030\024\ \017\r\024\007\016\013\036\020\024 \023\024\035\027\024\f\035\024\005\027\ \024\036 )Tj 0.203 Tw T* [(\006\017\030\022\031\035\016\030\027\024\036 )0.5(\017\f\f\036\004\036\027\017\036 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC [(\001\024\r. \215\031\002\035\017\022\026\006\017\005 )0.5(\024)]TJ /Span<>> BDC ( )Tj EMC 20.237 0 Td (\023\030\017)Tj 0 Tw (-)Tj 0.069 Tw -20.237 -1.218 Td [(\n\036\027\036\027\017\017 S)-21(T)35(ARR \023\024)]TJ /Span<>> BDC ( )Tj EMC (\023\024\r\024\007\031 \215\217\037 \002\024\035\034\001\036, \004\036\n\ \024)Tj /Span<>> BDC ( )Tj EMC (\035\033\002\024\n )Tj 0.102 Tw T* (\007\030\031\020\024\n \b\017\030\031\030\020\017\004\036\f\022\024\n \023\ \024\007\b\024\007\036. \200)Tj /Span<>> BDC ( )Tj EMC (\006\036\035\024\n, \r\f\036 \017\f\f\035\036)Tj 0 Tw (-)Tj 0.169 Tw T* (\007\024\r\026\027\017\016 \023\024\007\021\r\036\030\007\017\035\017 \f\ \027\017\032\036\027\017\036 \r\t\030\026\032\036\027\027\024\f\021\017 \ \224\210\212 )Tj 0.185 Tw T* [(\023\024\f\035\036 S)-21(T)34.9(ARR [98\226103]. POP-Q \027\036 \017\f\023\024\035\034\024\r\026\035\f\016\ \027\017 )]TJ 0.048 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\024\007\027\024\n \017\f\f\035\036\007\024\r\026\027\017\017. \212\036\235\ \036\022\024\020\030\026\235\017\016, \023\030\017\n\036\027\036\027\027\ \026\016 )Tj 0.205 Tw T* (\031)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\034\001\017\027\f\021\r\026 \023\026\006\017\036\027\021\024\ \022, \023\024\022\026\026\035\026 \022\026\022 \031\035\031\004\001\036\ \027\017\036 )Tj 0 Tw T* (\026\027\026\021\024\n\017\017, \021\026\022 \017)Tj /Span<>> BDC ( )Tj EMC (\024\021\f\031\021\f\021\r\017\036 \220\235\235\036\022\021\026.)Tj 0.264 Tw T* [(\215\024\002\024\004\027\t\n\017 )0.6(\016\r\035\036\027\017\016\n\017 )0.6(\023\024\f\035\036 )0.5(S)-21(T)35(ARR )0.5(\002\t\035\017 )0.6(\r\030\036\n\036\027)]TJ 0 Tw (-)Tj 0.26 Tw T* (\027\t\036 \017\n\023\036\030\026\021\017\r\027\t\036 \023\024\t\r\t \022\ )Tj /Span<>> BDC ( )Tj EMC (\007\036\235\036\022\026\006\017\017, \027\036\027\026\004\017)Tj 0 Tw (-)Tj 0.298 Tw T* [(\021\036\035\034\027\024\036 \022\030\024\r\024\021\036\004\036\027\017\036\ )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC (\023\024\f\035\036\024\023\036\030\026\006\017\024\027\027\026\016 \002\024\ \035\034. )Tj 0.003 Tw T* (\025\030\024\r\024\021\036\004\036\027\017\036 \024\f\021\026\027\026\r\035\ \017\r\026\035\017 \007\024\023\024\035\027\017\021\036\035\034\027\t\n\017\ \001\r\026)Tj 0 Tw (-)Tj 0.275 Tw T* [(\n\017. )0.5(\204\026\f\f\017\r\027\t\036 )0.6(\022\030\024\r\024\021\036\004\036\027\017\016 )0.5(\027\026\002\035\033\007\026\035\017\f\034 )0.6(\r)]TJ /Span<>> BDC ( )Tj EMC 20.166 0 Td (4,4% )Tj 0 Tw -20.166 -1.218 Td (\f\035\031\004\026\036\r [98\226103].)Tj /T1_1 1 Tf 1.106 Tw 0 -2.436 TD (\031\201\020\002\017\204\005\201\007\002\005\020\001\203\002\240\003 \235\ \217\017\b\202\204 \235\001\215 \004\217\201\201\005\004\210\007\007 )Tj 0 Tw 0 -1.218 TD (\201\005\004\b\217\210\005\001\005)Tj /T1_2 1 Tf 0.496 Tw T* (\200)Tj /Span<>> BDC ( )Tj EMC (\022\024\035\024\030\036\022\021\026\035\034\027\024\005 \017)Tj /Span<>> BDC ( )Tj EMC [(\024\002\013\036\b\017\030\031\030\020\017\004\036\f\022\024\005 )0.5(\023\030\026\022\021\017)]TJ 0 Tw (-)Tj 0.183 Tw T* (\022\036 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\215\217\037 \023\030\017\n\036\027\016\036\021\f\016 \017)Tj /Span<>> BDC ( )Tj EMC (\021\030\026\027\f\023\036\030\017\027\036\026\035\034\027\t\005 \007\024\ )Tj 0 Tw (-)Tj 0.524 Tw T* [(\f\021\031\023. \200\n\036\001\026\021\036\035\034\f\021\r\024 )0.5(\026\022\035\033\004\026\036\021\f\016 \r)]TJ /Span<>> BDC ( )Tj EMC (\r\t\023\024\035\027\036\027\017\017 )Tj 0.423 Tw 23.244 64.543 Td [(\023\024\023\036\030\036\004\027\024\020\024 \030\026\030\036\026 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC (\023\030\024\n\036\032\027\024\f\021\017, \030\026\f\f\036\004\036\027\017\ \016 )Tj 0.422 Tw T* (\030\036\022\021\024\r\026\020\017\027\026\035\034\027\024\005 \235\026\f\ \006\017\017 \n\036\032\007\031 \023\030\016\n\024\005 \022\017\001\022\024\ \005 )Tj 0.108 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\r\035\026\020\026\035\017\013\036\n, \026)Tj /Span<>> BDC ( )Tj EMC (\026\021\036\n \031\001\017\r\026\027\017\016 \023\024\007\f\035\017\017\ \f\021\024\005 \024\002\024)Tj 0 Tw (-)Tj 0.52 Tw T* [(\035\024\004\022\017 \023\030\016\n\024\005 )0.5(\022\017\001\022\017 \030\026\f\f\026\f\t\r\026\033\013\017\n\f\016 )0.5(\001\024\r\027\t\n )]TJ 0.281 Tw T* (\n\026\021\036\030\017\026\035\024\n \017)Tj /Span<>> BDC ( )Tj EMC (\023\035\017\022\026\006\017\017 \030\036\022\021\024\r\026\020\017\027\026\ \035\034\027\024\005 \235\026\f\006\017\017 )Tj 0.066 Tw T* [([85,90,104\226107]. )0.5(\215\030\017)]TJ /Span<>> BDC ( )Tj EMC 9.18 0 Td [(\215\217\037 )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC 2.754 0 Td [(\023\024\r\t\001\036\027\027\t\n )0.6(\007\026\r\035\036\027\017\036\n )]TJ 0.125 Tw -11.934 -1.218 Td [(\023\024\022\024\016 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 3.623 0 Td [(\023\030\016\n\024\005 )0.5(\022\017\001\022\036 )0.6(\(I )0.5(\021\017\023\026\), )0.5(\r\t\023\024\035\027\016\033\021 )0.6(\007\024\017\030\024)]TJ 0 Tw (-)Tj -3.623 -1.218 Td (\r\026\027\027\031\033 \f\235\017\027\022\021\036\030\024\021\024\n\017\033\ [108].)Tj 0.196 Tw T* [(\200 \030\026\027\007\024\n\017\017\030\024\r\026\027\027\024\n \017\f\f\ \035\036\007\024\r\026\027\017\017 F)20(ar)-37(id \017 \f\024\026\r\021. )]TJ 0.061 Tw T* ([96] \023\024)Tj /Span<>> BDC ( )Tj EMC (\030\036\031\035\034\021\026\021\026\n 6-\n\036\f\016\004\027\024\020\024\ \027\026\002\035\033\007\036\027\017\016 \021\030\026\027\f)Tj 0 Tw (-)Tj 0.354 Tw T* (\023\036\030\017\027\036\026\035\034\027\t\005 \007\024\f\021\031\023 \023\ \030\036\r\024\f\b\024\007\017\035 \021\030\026\027\f\026\027\026\035\034\ \027\t\005 )Tj 0.052 Tw T* (\022\026\022 \023\024)Tj /Span<>> BDC ( )Tj EMC (\f\021\030\031\022\021\031\030\027\t\n, \021\026\022 \017)Tj /Span<>> BDC ( )Tj EMC (\023\024 \235\031\027\022\006\017\024\027\026\035\034\027\t\n \023\024\022\ \026)Tj 0 Tw (-)Tj 0.049 Tw 0 -1.218 TD (\026\021\036\035\016\n. \025\024\027\f\021\017\023\026\006\017\016 \031\ \n\036\027\034\001\017\035\026\f\034 \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\026\b \021\030\026\027\f)Tj 0 Tw (-)Tj 0.139 Tw 0 -1.218 TD (\023\036\030\017\027\036\026\035\034\027\024\020\024 \007\024\f\021\031\023\ \026, \027\024 \027\036 \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \021\030\026\027\f\026\027\026\035\034)Tj 0 Tw (-)Tj 0.283 Tw 0 -1.218 TD (\027\024\020\024 \007\024\f\021\031\023\026. \215\024\022\026\026\021\036\ \035\017 CRAD \031\035\031\004\001\017\035\017\f\034 \023\024\f\035\036 \ )Tj 0.09 Tw T* (\021\030\026\027\f\023\036\030\017\027\036\026\035\034\027\024\020\024 \007\ \024\f\021\031\023\026 \(\022\026\022 \f)Tj /Span<>> BDC ( )Tj EMC (\035\036\r\026\021\024\030\024\023\035\026\f\021\017)Tj 0 Tw (-)Tj 0.171 Tw T* (\022\024\005, \021\026\022 \017)Tj /Span<>> BDC ( )Tj EMC (\002\036 \027\036\201\) \027\024 \027\036 \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \021\030\026\027\f\026\027\026\035\034\027\024\020\ \024 )Tj 0 Tw T* (\007\024\f\021\031\023\026.)Tj /T1_1 1 Tf 0 -2.436 TD (\033\005\206\020\b\217\201\217\204\001\020\017\b\007\004\020)Tj /T1_2 1 Tf 0.207 Tw 0 -1.218 TD (\214\036\r\026\021\024\030\024\023\035\026\f\021\017\022\026, \023\030\017\ )Tj /Span<>> BDC ( )Tj EMC (\022\024\021\024\030\024\005 \001\r\026\n\017 \f\002\035\017\032\026\033\ \021\f\016 )Tj 0.044 Tw T* (\n\t\001\006\t, \023\024\007\027\017\n\026\033\013\017\036 \026\007\027\ \017\005 \023\030\024\b\024\007, \031\035\031\004\001\026\036\021 \026\027\ \026)Tj 0 Tw (-)Tj 0.066 Tw T* (\021\024\n\017\033 \023\030\024\n\036\032\027\024\f\021\017 \017)Tj /Span<>> BDC ( )Tj EMC [(\030\036\022\021\024\r\026\020\017\027\026\035\034\027\024\005 )0.5(\023\036\030\036\020\024\030\024\007)]TJ 0 Tw (-)Tj 0.029 Tw T* (\022\017, \004\021\024 \023\024\007\021\r\036\030\032\007\026\036\021\f\016\ \r)Tj /Span<>> BDC ( )Tj EMC (\021\024\n \004\017\f\035\036, \007\036\235\036\022\024\020\030\026\235\017\ \036\005. )Tj 0.446 Tw T* (\214\036\r\026\021\024\030\024\023\035\026\f\021\017\022\026 \f\024\023\030\ \024\r\024\032\007\026\036\021\f\016 \030\017\f\022\024\n \023\024\f\035\ \036)Tj 0 Tw (-)Tj 0.122 Tw T* (\024\023\036\030\026\006\017\024\027\027\t\b \002\024\035\036\005 \r)Tj /Span<>> BDC ( )Tj EMC (\n\036\f\021\036 \024\023\036\030\026\006\017\017 \017)Tj /Span<>> BDC ( )Tj EMC (\007\017\f\023\026\030\036\031)Tj 0 Tw (-)Tj -0.007 Tw T* (\027\017\017, \b\024\021\016 \007\017\f\023\026\030\036\031\027\017\016 \ \027\026\002\035\033\007\026\035\026\f\034 \017)Tj /Span<>> BDC ( )Tj EMC (\022\024\020\007\026 \r\024 \r\030\036\n\016 )Tj 0.074 Tw T* (\230\003\025\203\230 \035\036\r\026\021\024\030\024\023\035\026\f\021\017\ \022\026 \027\036 \023\030\024\r\024\007\017\035\026\f\034 [109\226111].\ )Tj -0.033 Tw T* (\236\n\036\033\021\f\016 \031\022\026\026\027\017\016 \027\026)Tj /Span<>> BDC ( )Tj EMC (\024\002\255\036\022\021\017\r\027\024\036 \031\035\031\004\001\036\027\017\ \036 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\f\024)Tj 0 Tw (-)Tj 0.06 Tw T* (\b\030\026\027\016\033\013\017\b\f\016 \f\031\002\255\036\022\021\017\r\027\ \t\b \f\017\n\023\021\024\n\026\b \224\210\212 \017)Tj /Span<>> BDC ( )Tj EMC (\007\017\f\023\026)Tj 0 Tw (-)Tj 0.032 Tw T* (\030\036\031\027\017\017 \r)Tj /Span<>> BDC ( )Tj EMC (\021\036\004\036\027\017\036 \007\035\017\021\036\035\034\027\024\020\024\ \r\030\036\n\036\027\017 \023\024\f\035\036 \024\023\036\030\026)Tj 0 Tw (-)Tj T* (\006\017\017 [112].)Tj /T1_1 1 Tf 0 -2.436 TD (\026\217\006\005\b\020\002\002\240\005 \017\204\217\017\217\220\240 \004\ \217\201\201\005\004\210\007\007 \201\005\004\b\217\210\005\001\005)Tj /T1_2 1 Tf -0.004 Tc 0.609 Tw 0 -1.218 TD [(\224\021\030\036\n\016\f\034 \026\022\006\036\027\021\017\030\024\r\026\021\ \034 \023\024\035\024\032\017\021\036\035\034\027\t\036 \f\021\024\030\024\ \027\t)-4( )]TJ 0.092 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\027\017\r\036\035\017\030\024\r\026\021\034 \027\036\020\026\021\017\r\027\ \t\036 \r\035\017\016\027\017\016 \030\026\035\017\004\027\t\b \f\023\024\ )Tj 0 Tc 0 Tw (-)Tj -0.004 Tc 0.102 Tw T* [(\f\024\002\024\r \022\024\030\030\036\022\006\017\017 \030\036\022\021\024\ \006\036\035\036, \030\016\007 \026\r\021\024\030\024\r \023\030\017\n\036\ \027\016\033\021)-4( )]TJ 0.336 Tw T* [(\f\024\004\036\021\026\027\017\036 \f\023\024\f\024\002\024\r \031\022\030\ \036\023\035\036\027\017\016 \024\023\024\030\027\t\b \f\021\030\031\022\ \021\031\030)-4( )]TJ -0.053 Tw T* (\026\007\027\036\020\024 \022\024\n\023\026\030\021\n\036\027\021\026. \ \236\f\023\024\035\034\031\033\021\f\016 \f\024\004\036\021\026\027\017\ \016 \035\026\023\026)Tj 0 Tc 0 Tw (-)Tj -0.004 Tc 0.153 Tw T* (\030\024\f\022\024\023\017\004\036\f\022\024\005 \023\035\017\022\026\006\ \017\017 \003\224\200 \f)Tj /Span<>> BDC ( )Tj EMC [(\f\026\022\030\024\022\024\035\034\023\024\023\036\022\f\017\036\005)-3.9( )]TJ -0.037 Tw T* ([3], \026\022\030\t\021\017\016 \007\036\235\036\022\021\024\r \017)Tj /Span<>> BDC ( )Tj EMC [(\023\036\030\017\027\036\024\030\030\026\235\017\017 [85], \026\007\027\ \036\005)-3.9( )]TJ -0.005 Tw T* (\021\030\026\027\f\r\026\020\017\027\026\035\034\027\024\005 \022\024\035\ \034\023\024\030\030\026\235\017\017 \017)Tj /Span<>> BDC ( )Tj EMC [(\035\036\r\026\021\024\030\024\023\035\026\f\021\017\022\017)-3.9( )]TJ 0.098 Tw T* [([112], )0.5(\f\024\004\036\021\026\027\027\t\036 )0.6(\021\030\026\027\f\030\036\022\021\026\035\034\027\t\036 )0.5([113, )0.5(114], )0.5(\f\024\004\036)]TJ 0 Tc 0 Tw (-)Tj -0.004 Tc T* (\021\026\027\027\t\036 \021\030\026\027\f\r\026\020\017\027\026\035\034\027\ \t\036 \r\n\036\001\026\021\036\035\034\f\021\r\026 [115].)Tj 0 Tc 0.093 Tw T* [(\200 )0.5(\021\026\022\024\n )0.5(\030\026\027\024\024\002\030\026\017\017 )0.5(\n\024\020\031\021 )0.5(\031\f\n\026\021\030\017\r\026\021\034\f\016 )0.6(\023\024\023\t\021\022\017 )]TJ 0.176 Tw T* [(\007\017\235\235\036\030\036\027\006\017\030\024\r\026\027\027\024\020\024\ )0.5(\023\024\007\b\024\007\026, \027\024 \027\036 \017\f\022\035\033\004\026\ \036\021\f\016 )]TJ -0.009 Tw T* (\030\026\035\017\004\027\026\016 \021\030\026\022\021\024\r\022\026 \030\ \036\031\035\034\021\026\021\024\r \024\002\f\035\036\007\024\r\026\027\ \017\016, \023\030\017)Tj 0 Tw (-)Tj T* (\004\017\027 \017)Tj /Span<>> BDC ( )Tj EMC (\020\036\027\036\026 \030\036\022\021\024\006\036\035\036, \022\026\022\ \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\235\017\035\034 \f\023\036\006\017\026\035\017\f\021\026.)Tj /T1_1 1 Tf 0.252 Tw 0 -2.436 TD (\031\201\020\235\007\210\007\217\002\002\020\215 \020\235\002\215\215 \004\ \217\001\203\204\217\201\201\020\214\007\215 \002\020\b\007\206\002\240\207\ \007 )Tj 0.091 Tw 0 -1.218 TD (\b\004\020\002\215\207\007 \206)Tj /Span<>> BDC ( )Tj EMC (\017\201\020\206\002\005\002\007\007 \017)Tj /Span<>> BDC ( )Tj EMC (\020\202\205\207\005\002\b\020\210\007\005\003 \220\007\217\001\217\205\007\ \006\005)Tj 0 Tw (-)Tj T* (\017\004\007\207\007 \b\201\020\002\017\204\001\020\002\b\020\b\020\207\007\ )Tj /T1_2 1 Tf 0.467 Tw T* [(\230\003\025\203\230 )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC 4.385 0 Td [(\b\017\030\031\030\020\017\004\036\f\022\024\005 )0.6(\022\024\030\030\036\022\006\017\036\005 )0.5(\215\217\037 )0.6(\002\017\024\035\024)]TJ 0 Tw (-)Tj 0.994 Tw -4.385 -1.218 Td (\020\017\004\036\f\022\017\n \021\030\026\027\f\023\035\026\027\021\026\021\ \024\n \r)Tj /Span<>> BDC ( )Tj EMC (\030\036\022\021\024\r\026\020\017\027\026\035\034\027\024\n )Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 0 Tw 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\206)10(\002\036\033 \035\030\032\003\033)30(\n)42(\032)-21(\230\033\241)]TJ 57.136 0 Td (REVIEW)Tj /T1_3 1 Tf 25 0 0 25 505.4895 56.0378 Tm (193)Tj ET endstream endobj 884 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 0 0 0 1 k /GS1 gs /T1_0 1 Tf 10 0 0 10 70.8661 724.8299 Tm (\037\217\001\203\204\217\201\201\020\214\007\215, \017)Tj /Span<>> BDC ( )Tj EMC (\202\004\201\005\204\001\005\002\007\005\207 \b\201\020\002\017\204\001\020\ \002\b\020\b\217\207)Tj /T1_1 1 Tf 0.18 Tw 0 -1.218 TD (\230\030\026\027\f\r\026\020\017\027\026\035\034\027\026\016 \026\007\027\ \016\016 \022\024\035\034\023\024\030\030\026\235\017\016, \007\024\023\024\ \035\027\036\027)Tj 0 Tw (-)Tj 0.218 Tw T* (\027\026\016 \002\017\024\035\024\020\017\004\036\f\022\017\n \021\030\026\ \027\f\023\035\026\027\021\026\021\024\n \017\035\017 \f\017\027\021\036\ \021\017\004\036)Tj 0 Tw (-)Tj 0.358 Tw T* (\f\022\017\n \017\n\023\035\026\027\021\026\021\024\n, \024\006\036\027\036\ \027\026 \r)Tj /Span<>> BDC ( )Tj EMC (\030\016\007\036 \017\f\f\035\036\007\024\r\026\027\017\005 )Tj 0.272 Tw T* [([53,71\22673]. \224\031\n\n\026\030\027\024 974 \023\026\006\017\036\027\ \021\022\017 )0.5(\027\026\002\035\033\007\026\035\017\f\034 )]TJ 0.214 Tw T* (1,5\226157 \n\036\f\016\006\036\r. \200)Tj /Span<>> BDC ( )Tj EMC (\f\036\n\017 \017\f\f\035\036\007\024\r\026\027\017\016\b \017\031\004\026\ \035\017\f\034 )Tj 0.003 Tw 0 -1.218 TD (\002\017\024\035\024\020\017\004\036\f\022\017\036 \021\030\026\027\f\023\ \035\026\027\021\026\021\t, \r\022\035\033\004\026\016 \021\030\026\027\f\ \023\035\026\027\021\026)Tj 0 Tw (-)Tj 0.07 Tw 0 -1.218 TD (\021\t \023\024\007\f\035\017\017\f\021\024\005 \024\002\024\035\024\004\ \022\017 \021\024\027\022\024\005 \022\017\001\022\017 \017\035\017 \007\ \036\030\n\t )Tj 0.529 Tw T* [(\f\r\017\027\034\017, )0.6(\007\036\030\n\026\035\034\027\t\005 )0.5(\026\035\035\024\021\030\026\027\f\023\035\026\027\021\026\021, )0.6(\026\035\035\024\021\030\026\027)]TJ 0 Tw (-)Tj 0.365 Tw T* (\f\023\035\026\027\021\026\021 \001\017\030\024\022\024\005 \235\026\f\006\ \017\017 \002\036\007\030\026 \017)Tj /Span<>> BDC ( )Tj EMC (\022\024\035\035\026\020\036\027\024\r\t\036 )Tj 0.248 Tw T* (\021\030\026\027\f\023\035\026\027\021\026\021\t [12,15,71,74\22676]. \200\ )Tj /Span<>> BDC ( )Tj EMC (\021\030\036\b \017\f\f\035\036\007\024\r\026)Tj 0 Tw (-)Tj 0.067 Tw T* [(\027\017\016\b \017\031\004\026\035\017\f\034 \f\017\027\021\036\021\017\ \004\036\f\022\017\036 )0.5(\f\036\021\004\026\021\t\036 \017\n\023\035\026\027\021\026\021\t, )]TJ 0.368 Tw 0 -1.218 TD (\r\022\035\033\004\026\016 \023\024\035\017\020\035\017\022\024\035\036\r\ \t\005, \022\024\n\023\024\017\021\027\t\005 \017\n\023\035\026\027\021\ \026\021 )Tj 0 Tw 0 -1.218 TD (\253\200\017\022\030\017\035-\215\030\024\035\036\027\273 \017)Tj /Span<>> BDC ( )Tj EMC (\017\n\023\035\026\027\021\026\021 \253\215\030\024\035\036\027\273 [71\226\ 73,75].)Tj -0.013 Tw 0 -1.218 TD (\211 \032\036\027\013\017\027, \022\024\021\024\030\t\n \002\t\035 \031\f\ \021\026\027\024\r\035\036\027 \021\030\026\027\f\023\035\026\027\021\026\ \021 \017\035\017 )Tj 0.247 Tw T* (\017\n\023\035\026\027\021\026\021 \r)Tj /Span<>> BDC ( )Tj EMC (\026\007\027\036\n \022\024\n\023\026\030\021\n\036\027\021\036 \(\030\036\ \022\021\024\r\026\020\017\027\026\035\034)Tj 0 Tw (-)Tj 0.245 Tw T* (\027\024\036 \023\030\024\f\021\030\026\027\f\021\r\024\), \027\026\002\035\ \033\007\026\035\024\f\034 \031\035\031\004\001\036\027\017\036 \026\027\ \026\021\024)Tj 0 Tw (-)Tj 0.106 Tw T* (\n\017\017 \003\224\200, \024\002\255\036\022\021\017\r\017\017\030\024\ \r\026\027\027\024\036 POP-Q \(7 \017\f\f\035\036\007\024\r\026)Tj 0 Tw (-)Tj 0.258 Tw T* (\027\017\005, 547 \023\026\006\017\036\027\021\024\r, 12\226157)Tj /Span<>> BDC ( )Tj EMC (\n\036\f\016\006\036\r \027\026\002\035\033\007\036\027\017\016\) )Tj 0.025 Tw T* ([77\22679], \026)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\032\036)Tj /Span<>> BDC ( )Tj EMC (\227 \023\030\017\n\036\030\027\024 \031)Tj /Span<>> BDC ( )Tj EMC (\023\024\035\024\r\017\027\t \023\026\006\017\036\027\021\024\r )Tj 0.281 Tw T* (\023\024)Tj /Span<>> BDC ( )Tj EMC (\030\036\031\035\034\021\026\021\026\n \007\036\235\036\022\024\020\030\ \026\235\017\017 [80], 29 \023\026\006\017\036\027\021\024\r, )Tj 0.116 Tw T* (10\22614)Tj /Span<>> BDC ( )Tj EMC (\n\036\f\016\006\036\r \027\026\002\035\033\007\036\027\017\016. \207\024\ \035\034\001\026\016 \004\026\f\021\034 \f\017\n\023\021\024)Tj 0 Tw (-)Tj 0.086 Tw T* (\n\024\r \224\210\212 \031)Tj /Span<>> BDC ( )Tj EMC (\032\036\027\013\017\027, \024\023\036\030\017\030\024\r\026\027\027\t\b\ \f)Tj /Span<>> BDC ( )Tj EMC (\017\f\023\024\035\034\024\r\026\027\017)Tj 0 Tw (-)Tj 0.344 Tw T* (\036\n \021\030\026\027\f\023\035\026\027\021\026\021\026 \017\035\017 \f\ \017\027\021\036\021\017\004\036\f\022\024\020\024 \017\n\023\035\026\027\ \021\026\021\026, )Tj 0 Tw T* (\030\036\020\030\036\f\f\017\030\024\r\026\035\026.)Tj 0.032 Tw T* (\203\036\032\036\035\026\021\036\035\034\027\t\036 \016\r\035\036\027\017\ \016 \023\024\f\035\036 \031\f\021\026\027\024\r\022\017 \021\030\026\027\ \f\023\035\026\027)Tj 0 Tw (-)Tj 0.208 Tw T* (\021\026\021\026 \r\022\035\033\004\026\035\017 \007\017\f\023\026\030\036\ \031\027\017\033 )Tj /T1_2 1 Tf [(de nov)13(o)]TJ /T1_1 1 Tf ( \017)Tj /Span<>> BDC ( )Tj EMC (\023\024\f\021\024\016\027\027\031\033 )Tj 0.097 Tw T* [(\007\017\f\023\026\030\036\031\027\017\033, )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC 6.813 0 Td [(\007\024\035\036\005 )0.5(\024\021 10 )0.5(\007\024)]TJ /Span<>> BDC ( )Tj EMC [(69%, )0.5(0\22612% \f\035\031\004\026\036\r )]TJ 0.154 Tw -6.813 -1.218 Td [(\030\026\f\b\024\032\007\036\027\017\016 )0.6(\001\r\024\r )0.5(\030\026\027\t/\220\030\024\017\005. )0.6(\232\021\024 )0.5(\022\026\f\026\036\021\f\016 )0.6(\f\017\027)]TJ 0 Tw (-)Tj 0.056 Tw T* (\021\036\021\017\004\036\f\022\017\b \017\n\023\035\026\027\021\026\021\024\ \r, \021\024 \f\024\024\002\013\026\035\024\f\034 \024)Tj /Span<>> BDC ( )Tj EMC (0\22613% \004\026)Tj 0 Tw (-)Tj 0.053 Tw T* (\f\021\024\021\036 \030\026\r\017\021\017\016 \220\030\024\017\005, \024\ \002 \031\f\031\020\031\002\035\036\027\017\017 \016\r\035\036\027\017\005\ \007\017\f)Tj 0 Tw (-)Tj 0.143 Tw T* (\023\026\030\036\031\027\017\017 \024\021 6 \007\024)Tj /Span<>> BDC ( )Tj EMC (69%. \200)Tj /Span<>> BDC ( )Tj EMC (\f\024\r\024\022\031\023\027\024\f\021\017 \023\031\002\035\017\022\026\006\ \017\005 )Tj -0.026 Tw T* (\023\030\024\f\035\036\032\017\r\026\036\021\f\016 \021\036\027\007\036\027\ \006\017\016 \024\021\022\026\026 \024\021 \023\030\017\n\036\027\036\027\ \017\016 \022\026\022 )Tj 0.239 Tw T* (\f\017\027\021\036\021\017\004\036\f\022\017\b \017\n\023\035\026\027\021\ \026\021\024\r, \021\026\022 \017)Tj /Span<>> BDC ( )Tj EMC (\022\f\036\027\024\021\030\026\027\f\023\035\026\027)Tj 0 Tw (-)Tj 0.131 Tw T* (\021\026\027\021\024\r \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\035\036\004\036\027\017\017 \032\036\027\013\017\027 \217\200. \200)Tj /Span<>> BDC ( )Tj EMC (\023\031\002\035\017\022\026\006\017\016\b \023\024)Tj 0 Tw (-)Tj -0.044 Tw T* (\f\035\036\007\027\017\b 10 \035\036\021 \024\021\n\036\004\026\036\021\f\ \016, \004\021\024 \024\021\007\026\035\036\027\027\026\016 \220\235\235\ \036\022\021\017\r)Tj 0 Tw (-)Tj 0.201 Tw T* (\027\024\f\021\034 \022\f\036\027\024\023\035\026\f\021\017\022\017 \027\ \026\004\017\021\036\035\034\027\024 \031\f\021\031\023\026\036\021 \021\ \026\022\024\r\024\005 )Tj 0.057 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\017\f\023\024\035\034\024\r\026\027\017\036\n \f\017\027\021\036\021\017\ \004\036\f\022\017\b \f\036\021\004\026\021\t\b \023\030\024\021\036\024\ \r. )Tj 0.132 Tw T* (\200)Tj /Span<>> BDC ( )Tj EMC (\021\024 \032\036 \r\030\036\n\016, \023\030\036\017\n\031\013\036\f\021\ \r \023\036\030\036\007 \023\035\026\f\021\017\022\024\005 \n\036\f\021)Tj 0 Tw (-)Tj 0.019 Tw T* (\027\t\n\017 \021\022\026\027\016\n\017 \017\f\023\024\035\034\024\r\026\ \027\017\036 \f\036\021\004\026\021\t\b \017\n\023\035\026\027\021\024\r\ \027\036 )Tj 0 Tw T* (\023\024\022\026\t\r\026\036\021 [77\22679].)Tj 0.064 Tw T* (\200 \023\024\f\035\036\007\027\017\036 \020\024\007\t \r\f\036 \002\024\ \035\034\001\036 \023\024\016\r\035\016\036\021\f\016 \007\026\027\027\t\ \b \024\002 )Tj 0.233 Tw T* (\026\022\021\017\r\027\024\n \017)Tj /Span<>> BDC ( )Tj EMC (\031\f\023\036\001\027\024\n \r\027\036\007\030\036\027\017\017 \030\024\ \002\024\021-\026\f\f\017\f\021\017\030\024)Tj 0 Tw (-)Tj 0.133 Tw T* (\r\026\027\027\t\b \021\036\b\027\024\035\024\020\017\005 \r)Tj /Span<>> BDC ( )Tj EMC (\030\026\035\017\004\027\t\b \024\002\035\026\f\021\016\b \b\017\030\031\ \030\020\017\017, )Tj 0.109 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC 0.815 0 Td [(\021\024\n )0.5(\004\017\f\035\036 )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC 5.36 0 Td [(\023\030\017 )0.5(\022\024\030\030\036\022\006\017\017 )0.6(\f\017\027\007\030\024\n\026 )0.5(\024\002\f\021\030\031\022\021\017\r)]TJ 0 Tw (-)Tj -6.176 -1.218 Td (\027\024\005 \007\036\235\036\022\026\006\017\017 [81].)Tj /T1_0 1 Tf 1.023 Tw 0 -2.436 TD [(\216\017\b\201\020\002\005\002\007\005 \235\005\214\005\004\b\217\206 )0.5(\206)]TJ /Span<>> BDC ( )Tj EMC (\020\206\007\017\007\207\217\017\b\007 \217\b )Tj 0 Tw 0 -1.218 TD (\001\217\004\020\001\007\020\210\007\007)Tj /T1_1 1 Tf 0.871 Tw T* [(\204\036\f\021\027\024\036 )0.6(\006\036\035\036\027\026\023\030\026\r\035\036\027\027\024\036 )0.6(\031\f\021\030\026\027\036\027\017\036 )0.5(\007\036\235\036\022)]TJ 0 Tw (-)Tj 0.3 Tw T* (\021\024\r \(\204\037\211\212\) \023\024\007\030\026\031\n\036\r\026\036\ \021 \023\030\017\006\036\035\034\027\024\036 \r\t\016\r\035\036\027\017\ \036 )Tj 0.365 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\031\f\021\030\026\027\036\027\017\036 \f\035\026\002\t\b \n\036\f\021 \r\ )Tj /Span<>> BDC ( )Tj EMC (\024\023\024\030\027\t\b \f\021\030\031\022\021\031\030\026\b )Tj 0.457 Tw T* [(\(\030\036\022\021\024\r\026\020\017\027\026\035\034\027\026\016 )0.5(\235\026\f\006\017\016 \017)]TJ /Span<>> BDC ( )Tj EMC (\f\031\b\024\032\017\035\034\027\t\005 \006\036\027\021\030 )Tj 0.71 Tw T* [(\023\030\024\n\036\032\027\024\f\021\017\) )0.5(\003\224\200. \225\021\017 \024\023\036\030\026\006\017\017 \024\006\036\ \027\017\r\026\035\017\f\034 )]TJ 0.267 Tw 23.244 64.543 Td (\r)Tj /Span<>> BDC ( )Tj EMC (7)Tj /Span<>> BDC ( )Tj EMC (\017\f\f\035\036\007\024\r\026\027\017\016\b [9,41,60,64\22666,82\22684]\ . \200)Tj /Span<>> BDC ( )Tj EMC (\f\031\n\n\036 )Tj 0.13 Tw T* (561)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\022\026 \023\024\007\r\036\030\020\035\026\f\ \034 \027\026\002\035\033\007\036\027\017\033 \024\021 3 \007\024)Tj /Span<>> BDC ( )Tj EMC (68 )Tj 0.063 Tw T* (\n\036\f\016\006\036\r. \204\037\211\212 \027\026\004\017\n\024 \031\035\ \031\004\001\017\035\024 \f\021\030\031\022\021\031\030\031 \003\224\200\ \023\024)Tj 0 Tw (-)Tj 0.085 Tw T* (\f\035\036 \024\023\036\030\026\006\017\017, \027\024 \r\035\017\016\027\ \017\036 \027\026)Tj /Span<>> BDC ( )Tj EMC (\224\210\212 \002\t\035\024 \n\036\027\036\036 \r\t\030\026)Tj 0 Tw (-)Tj 0.099 Tw T* (\032\036\027\027\t\n. \211\035\031\004\001\036\027\017\036 \023\024)Tj /Span<>> BDC ( )Tj EMC (POP-Q \024\021\n\036\004\036\027\024 \031)Tj /Span<>> BDC ( )Tj EMC (365 \023\026\006\017)Tj 0 Tw (-)Tj 0.131 Tw T* (\036\027\021\024\022, \r)Tj /Span<>> BDC ( )Tj EMC (\021.\004.)Tj /Span<>> BDC ( )Tj EMC (\227 \021\024\004\022\017 Bp \031)Tj /Span<>> BDC ( )Tj EMC (244, \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\027\026\002\035\033\007\036\027\017\017 \024\021 )Tj 0.015 Tw 0 -1.218 TD (3 \007\024)Tj /Span<>> BDC ( )Tj EMC (47)Tj /Span<>> BDC ( )Tj EMC (\n\036\f\016\006\036\r. \215\030\036\007\f\021\026\r\035\036\027\026 \023\ \024\035\024\032\017\021\036\035\034\027\026\016 \007\017\027\026)Tj 0 Tw (-)Tj -0.031 Tw 0 -1.218 TD (\n\017\022\026 \023\024)Tj /Span<>> BDC ( )Tj EMC [(\001\022\026\035\036 Baden\226W)12.1(alk)10(er \031)]TJ /Span<>> BDC ( )Tj EMC (249 \023\026\006\017\036\027\021\024\022, \023\024)Tj /Span<>> BDC ( )Tj EMC (\007\026\027)Tj 0 Tw (-)Tj -0.02 Tw T* [(\027\t\n )0.5(\211\003\236)]TJ /Span<>> BDC ( )Tj EMC 3.7 0 Td [(\227 )0.5(\031)]TJ /Span<>> BDC ( )Tj EMC 1.87 0 Td [(137 )0.5(\023\026\006\017\036\027\021\024\022. )0.6(\211)]TJ /Span<>> BDC ( )Tj EMC 7.236 0 Td [(\r\f\036\b )0.5(\032\036\027\013\017\027, )0.6(\022\024\021\024\030\t\n )]TJ 0.114 Tw -12.806 -1.218 Td (\002\t\035\024 \r\t\023\024\035\027\036\027\024 \204\037\211\212 \(561\)\ , \024\021\n\036\004\036\027\024 \031\n\036\027\034\001\036\027\017\036 \ )Tj 0.201 Tw T* (\023\030\024\035\026\023\f\026 \003\224\200. \224\210\212 \030\036\020\030\ \036\f\f\017\030\024\r\026\035 \031)Tj /Span<>> BDC ( )Tj EMC (\032\036\027\013\017\027, \022\024\021\024)Tj 0 Tw (-)Tj 0.146 Tw T* (\030\t\n \002\t\035\024 \r\t\023\024\035\027\036\027\024 \204\037\211\212\ , \r)Tj /Span<>> BDC ( )Tj EMC (\021.\004. \031)Tj /Span<>> BDC ( )Tj EMC (331 \023\026\006\017\036\027\021\022\017 )Tj 0.09 Tw 0 -1.218 TD (\031\n\036\027\034\001\017\035\026\f\034 \004\026\f\021\024\021\026 \017\ \f\023\024\035\034\024\r\026\027\017\016 \023\026\035\034\006\036\r\024\ \020\024 \023\024)Tj 0 Tw (-)Tj 0.171 Tw 0 -1.218 TD [(\f\024\002\017\016 )0.5(\023\030\017)]TJ /Span<>> BDC ( )Tj EMC [(\007\036\235\036\022\026\006\017\017. )0.5(\232\026\f\021\024\021\026 \022\024\027\f\021\017\023\026\006\017\017 )0.6(\022\026\022 \027\036 )]TJ 0.079 Tw 0 -1.218 TD (\031\n\036\027\034\001\017\035\026\f\034, \021\026\022 \017)Tj /Span<>> BDC ( )Tj EMC (\031\n\036\027\034\001\017\035\026\f\034, \027\024 \027\036 \031\r\036\035\ \017\004\017\035\026\f\034 )Tj -0.018 Tw T* (\027\017 \r)Tj /Span<>> BDC ( )Tj EMC (\024\007\027\024\n \017)Tj /Span<>> BDC ( )Tj EMC (\017\f\f\035\036\007\024\r\026\027\017\005 \(3\22647 \n\036\f\016\006\036\ \r \027\026\002\035\033\007\036)Tj 0 Tw (-)Tj -0.033 Tw T* (\027\017\016\). \204\037\211\212 \023\030\017\r\036\035\024 \022)Tj /Span<>> BDC ( )Tj EMC (\r\t\f\024\022\024\n\031 \f\031\002\255\036\022\021\017\r\027\024\n\031 \ \023\024\022\026)Tj 0 Tw (-)Tj -0.021 Tw T* (\026\021\036\035\033 \017\035\036\004\036\027\017\016 \(\021.\036. \023\ \024)Tj /Span<>> BDC ( )Tj EMC (\024\021\t\r\026\n \023\026\006\017\036\027\021\024\r \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\027\036)Tj 0 Tw (-)Tj -0.095 Tw T* (\r\026\035\017\007\017\030\024\r\026\027\027\024\n \024\023\030\024\f\036\ \))Tj /Span<>> BDC ( )Tj EMC (\227 \007\024)Tj /Span<>> BDC ( )Tj EMC (85%. \203\036\032\036\035\026\021\036\035\034\027\t\n\017 )Tj 0.302 Tw T* (\016\r\035\036\027\017\016\n\017 \002\t\035\017 \007\017\f\023\026\030\036\ \031\027\017\016 \(2\22611%\) \017)Tj /Span<>> BDC ( )Tj EMC (\021\036\027\036\n\t )Tj 0 Tw T* (\(3%\) [60, 62, 85].)Tj /T1_0 1 Tf 0.252 Tw 0 -2.436 TD (\031\201\020\235\007\210\007\217\002\002\020\215 \020\235\002\215\215 \004\ \217\001\203\204\217\201\201\020\214\007\215 \002\020\b\007\206\002\240\207\ \007 )Tj 0 Tw 0 -1.218 TD (\b\004\020\002\215\207\007)Tj /T1_1 1 Tf -0.008 Tc 0.229 Tw T* (\230\030\026\007\017\006\017\024\027\027\026\016 \(\f \023\035\017\022\026\ \006\017\036\005 \030\036\022\021\024\r\026\020\017\027\026\035\034\027\024\ \005 \235\026\f)Tj 0 Tc 0 Tw (-)Tj -0.008 Tc 0.704 Tw T* [(\006\017\017\) \026\007\027\016\016 \022\024\035\034\023\024\030\030\026\ \235\017\016 \027\026\021\017\r\027\t\n\017 \021\022\026\027\016\n\017)-8( )]TJ 0.214 Tw T* [(\(\230\003\025\203\230\) )0.5(\024\006\036\027\036\027\026 )0.6(\r)]TJ /Span<>> BDC ( )Tj EMC 8.385 0 Td [(13 )0.5(\017\f\f\035\036\007\024\r\026\027\017\016\b. )0.5(\200)]TJ /Span<>> BDC ( )Tj EMC 9.232 0 Td [(\027\017\b )0.6(\r\024\001\035\017)-8( )]TJ 0.065 Tw -17.618 -1.218 Td (1337 \023\026\006\017\036\027\021\024\022 \f)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\017\024\007\024\n \027\026\002\035\033\007\036\027\017\016 \ 3\22641)Tj /Span<>> BDC ( )Tj EMC [(\n\036\f\016\006.)-8( )]TJ 0.208 Tw T* (\211)Tj /Span<>> BDC ( )Tj EMC (130 \023\026\006\017\036\027\021\024\r \215\217\037 \r\t\016\r\035\036\027\ \024 \023\030\017)Tj /Span<>> BDC ( )Tj EMC [(\007\036\235\036\022\024\020\030\026\235\017\017,)-8( )]TJ 0.254 Tw T* (\031)Tj /Span<>> BDC ( )Tj EMC (154)Tj /Span<>> BDC ( )Tj EMC (\227 \023\030\017)Tj /Span<>> BDC ( )Tj EMC [(\022\035\017\027\017\004\036\f\022\024\n \024\f\n\024\021\030\036. \200\t\ \030\026\032\036\027\027\024\f\021\034)-8( )]TJ 0.014 Tw T* [(\026\027\026\021\024\n\017\004\036\f\022\017\b )0.6(\007\036\235\036\022\021\024\r )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC 11.17 0 Td [(\224\212\210 )0.6(\030\036\020\030\036\f\f\017\030\024\r\026\035\017 )0.5(\023\024\f\035\036)-8( )]TJ 0.115 Tw -11.17 -1.218 Td (\r\n\036\001\026\021\036\035\034\f\021\r\026, \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\027\017\022\024\005 \004\026\f\021\024\021\036 \023\024\f\035\036\024\023\ \036\030\026\006\017\024\027)Tj 0 Tc 0 Tw (-)Tj -0.008 Tc -0.007 Tw T* (\027\t\b \024\f\035\024\032\027\036\027\017\005 [2,48,60,61,65,86\22691]\ . \200)Tj /Span<>> BDC ( )Tj EMC [(\002\024\035\034\001\017\027\f\021\r\036)-8( )]TJ 0.586 Tw T* [(\017\f\f\035\036\007\024\r\026\027\017\005 )0.5(\026\027\026\021\024\n\017\004\036\f\022\017\005 )0.5(\220\235\235\036\022\021 )0.6(\024\006\036\027\017\r\026\035\f\016)-8( )]TJ 0.054 Tw T* (\023\024)Tj /Span<>> BDC ( )Tj EMC 1.263 0 Td [(\f\017\f\021\036\n\036 )0.5(POP-Q. )0.6(793 )0.5(\023\026\006\017\036\027\021\022\017 )0.5(\023\030\024\007\036\n\024\027\f\021\030\017\030\024\r\026)]TJ 0 Tc 0 Tw (-)Tj -0.008 Tc -0.005 Tw -1.263 -1.218 Td (\035\017 \031\n\036\027\034\001\036\027\017\036 \023\030\024\035\026\023\ \f\026 \003\224\200 \023\024)Tj /Span<>> BDC ( )Tj EMC (\021\024\004\022\036 \253Bp\273, 110 \023\026\006\017)Tj 0 Tc 0 Tw (-)Tj -0.008 Tc -0.067 Tw T* (\036\027\021\024\r)Tj /Span<>> BDC ( )Tj EMC (\227 \023\024)Tj /Span<>> BDC ( )Tj EMC (\021\024\004\022\036 \253Ap\273. \211)Tj /Span<>> BDC ( )Tj EMC [(367 \023\026\006\017\036\027\021\024\022 \r\t\030\026\032\036\027\027\024\ \f\021\034)-8( )]TJ 0.333 Tw T* (\023\030\024\035\026\023\f\026 \003\224\200 \022\035\026\f\f\017\235\017\ \006\017\030\024\r\026\027\026 \023\024)Tj /Span<>> BDC ( )Tj EMC [(Baden\226W)12(alk)10(er.)-8( )]TJ -0.034 Tw T* (\211)Tj /Span<>> BDC ( )Tj EMC [(\r\f\036\b \023\026\006\017\036\027\021\024\022 \007\024\f\021\017\020\027\ \031\021\024 \031\035\031\004\001\036\027\017\036 \026\027\026\021\024\n\ \017\017 )0.5(\003\224\200.)-8( )]TJ 0.215 Tw T* (\211)Tj /Span<>> BDC ( )Tj EMC [(445 \f\027\017\017\035\026\f\034 \004\026\f\021\024\021\026 \017\f\023\024\ \035\034\024\r\026\027\017\016 \023\026\035\034\006\036\r\024\020\024)-8( )]TJ 0.078 Tw T* (\023\024\f\024\002\017\016 \023\030\017)Tj /Span<>> BDC ( )Tj EMC [(\007\036\235\036\022\026\006\017\017 \017 \017\002\t\021\024\004\027\024\ \020\024 \027\026\021\031\032\017\r\026\027\017\016,)-8( )]TJ 0.175 Tw T* (\023\030\017\004\036\n \031)Tj /Span<>> BDC ( )Tj EMC (293 \023\026\006\017\036\027\021\024\022 \023\030\017\n\036\027\016\035\017\ \f\034 \r\026\035\017\007\017\030\024\r\026\027)Tj 0 Tc 0 Tw (-)Tj -0.008 Tc 0.331 Tw T* [(\027\t\036 \024\023\030\024\f\027\017\022\017. \212\017\027\026\n\017\022\ \026 \f\017\n\023\021\024\n\024\r \022\024\027\f\021\017\023\026\006\017\ \017)-8( )]TJ -0.048 Tw T* (\031)Tj /Span<>> BDC ( )Tj EMC (307 \023\026\006\017\036\027\021\024\r \027\036 \024\021\n\036\004\036\027\ \026, \031)Tj /Span<>> BDC ( )Tj EMC (165 \023\026\006\017\036\027\021\024\r)Tj /Span<>> BDC ( )Tj EMC (\227 \023\024\035\024)Tj 0 Tc 0 Tw (-)Tj -0.008 Tc 0.024 Tw T* (\032\017\021\036\035\034\027\026\016, \026)Tj /Span<>> BDC ( )Tj EMC (\031 124)Tj /Span<>> BDC ( )Tj EMC [(\227 \024\021\030\017\006\026\021\036\035\034\027\026\016. \203\036\032\036\ \035\026\021\036\035\034\027\t\n)-8( )]TJ 0.01 Tw T* (\016\r\035\036\027\017\036\n \f\021\026\035\026 \007\017\f\023\026\030\036\ \031\027\017\016 \(\024\021 0 \007\024)Tj /Span<>> BDC ( )Tj EMC (19%\), \002\036 \031\022\026\026)Tj 0 Tc 0 Tw (-)Tj -0.008 Tc T* (\027\017\005 \024)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\007\024\035\032\017\021\036\035\034\027\024\f\021\017 \017)Tj /Span<>> BDC ( )Tj EMC (\007\026\035\034\027\036\005\001\036\n \035\036\004\036\027\017\017.)Tj 0 Tc 0.213 Tw T* (\200\t\007\036\035\036\027\017\036 \017)Tj /Span<>> BDC ( )Tj EMC (\r\024\f\f\021\026\027\024\r\035\036\027\017\036 \023\030\024\022\f\017\n\ \026\035\034\027\t\b \024\021\007\036)Tj 0 Tw (-)Tj 0.188 Tw T* (\035\024\r \030\036\022\021\024\r\026\020\017\027\026\035\034\027\024\005\ \235\026\f\006\017\017 \017)Tj /Span<>> BDC ( )Tj EMC (\021\030\026\027\f\r\026\020\017\027\026\035\034\027\024)Tj 0 Tw (-)Tj 0.21 Tw T* [(\020\024 )0.5(\007\024\f\021\031\023\026 )0.6(\024\f\031\013\036\f\021\r\017\n\024 )0.5(\007\024\f\021\026\021\024\004\027\024 )0.6(\035\036\020\022\024. )0.5(\224\035\036\007\031\036\021 )]TJ 0.161 Tw T* (\017\002\036\020\026\021\034 \004\030\036\n\036\030\027\024\005 \030\026\ \007\017\022\026\035\034\027\024\f\021\017 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\017\f\f\036\004\036\027\017\017 )Tj 0.137 Tw T* (\003\224\200 \r\024 \017\002\036\032\026\027\017\036 \235\024\030\n\017\ \030\024\r\026\027\017\016 \020\030\031\002\t\b \023\024\f\035\036\024\023\ \036)Tj 0 Tw (-)Tj 0.009 Tw T* (\030\026\006\017\024\027\027\t\b \030\031\002\006\024\r \017)Tj /Span<>> BDC ( )Tj EMC (\f\027\017\032\036\027\017\016 \f\036\022\f\031\026\035\034\027\024\005 \ \235\031\027\022\006\017\017 )Tj 0 Tw T* (\031)Tj /Span<>> BDC ( )Tj EMC (\032\036\027\013\017\027 \217\200 [2,61].)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\206)10(\002\036\033 \035\030\032\003\033)30(\n)42(\032)-21(\230\033\241)]TJ 57.136 0 Td (REVIEW)Tj -57.136 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 2)69(4, \023\0224, 202)23(5)]TJ 43.013 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 2)69(4, \023\0224, 202)23(5)]TJ /T1_4 1 Tf 25 0 0 25 20.7776 56.0378 Tm (192)Tj ET endstream endobj 883 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\033\016\017)-10(\026)11(\025\212\016\t\016 \200\022\216\016\215\232\021\215: \215\016\201\016\020\ \016\215\215\220\016 \r\025\222\201\025\b\220 \(\025\235\213\025\201\022\ \t\021\026)11(\016\201\001\026)-20(\200\201\220\))]TJ 41.66 0 Td [(Rectocele in females: unr)31(esolv)12(ed issues \(r)31(e)11(vie)11(w\))]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0.004 Tc 0.511 Tw 10 0 0 10 42.5197 724.8299 Tm (\030\026\007\036\035\024\r, \023\024\f\r\016\013\036\027\027\t\b \215\230\ \210, \027\026\030\031\001\036\027\017\016\n \235\031\027\022)Tj 0 Tc 0 Tw (-)Tj 0.004 Tc 0.124 Tw 0 -1.218 TD [(\006\017\017 \022\017\001\036\004\027\017\022\026, \n\024\004\036\r\024\020\ \024 \023\031\t\030\016 \(POPDI-6, CRAD-8,)4( )]TJ 0.299 Tw T* (UDI-6, \f\024\024\021\r\036\021\f\021\r\036\027\027\024\) [46\22648]. \212\ \035\016 \024\006\036\027\022\017 \r\035\017)Tj 0 Tc 0 Tw (-)Tj 0.004 Tc 0.294 Tw T* (\016\027\017\016 \027\026)Tj /Span<>> BDC ( )Tj EMC [(\022\026\004\036\f\021\r\024 \032\017\027\017 \f\021\030\036\f\f\024\r\024\ \020\024 \027\036\007\036\030\032\026\027\017\016)4( )]TJ 0.176 Tw T* [(\n\024\004\017 \017\f\023\024\035\034\031\036\021\f\016 \024\023\030\024\ \f\027\017\022 ICIQ-SF \(Inter)-15(na)15(t)-32(ional)4( )]TJ 0.545 Tw T* [(Conf\351r)-24(ence on Incont)-32(inence Q)-16(uest)-31.9(ionnair)-24(e S)-16(hor)-22(t)4( )]TJ 0.426 Tw 0 -1.218 TD [(F)10(or)-16(m\) [49\22651]. \200\026\032\027\t\n \026\f\023\036\022\021\024\n \022\026\ \004\036\f\021\r\026 \032\017)]TJ 0 Tc 0 Tw (-)Tj 0.004 Tc 0.281 Tw 0 -1.218 TD [(\027\017 \032\036\027\013\017\027 \217\200 \016\r\035\016\036\021\f\016 \ \f\036\022\f\031\026\035\034\027\026\016 \235\031\027\022\006\017\016, \036\ \036)4( )]TJ 0.323 Tw T* (\027\026\030\031\001\036\027\017\016 \r\f\021\030\036\004\026\033\021\f\016\ \031)Tj /Span<>> BDC ( )Tj EMC [(\022\026\032\007\024\005 \021\030\036\021\034\036\005. \224\030\036\007\017\ )4( )]TJ 0.352 Tw T* (\024\f\027\024\r\027\t\b \032\026\035\024\002)Tj /Span<>> BDC ( )Tj EMC (\227 \007\017\f\023\026\030\036\031\027\017\016, \027\026\030\031\001\036\ \027\017\036 \023\024)Tj 0 Tc 0 Tw (-)Tj 0.004 Tc 0.102 Tw T* (\035\024\r\024\020\024 \r\035\036\004\036\027\017\016, \023\030\024\002\035\ \036\n\t \f)Tj /Span<>> BDC ( )Tj EMC [(\007\024\f\021\017\032\036\027\017\036\n \024\030\020\026\n\026)4( )]TJ 0.114 Tw T* [([50,52,54]. \210\023\030\024\f\027\017\022 PISQ-12 \(P)30.1(el)30(v)-16(ic Or)-32(gan P)35(r)-32(ol)-16(apse)4( )]TJ 0.441 Tw 0 -1.218 TD [(Incont)-32(inence )0.5(Se)-18(xual )0.5(Q)-16(uest)-32(ionnair)-24(e\) )0.5(\023\030\036\007\027\026\027\026\004\036\027)4( )]TJ 0.042 Tw 0 -1.218 TD (\007\035\016 \024\006\036\027\022\017 \f\036\022\f\031\026\035\034\027\024\ \005 \235\031\027\022\006\017\017 \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\022 \f)Tj /Span<>> BDC ( )Tj EMC [(\215\230\210)4( )]TJ -0.004 Tw 0 -1.218 TD ([50,52].)Tj /T1_2 1 Tf 0 Tc 0 Tw 0 -2.436 TD (\033\005\006\005\220\002\240\005 \204\217\235\255\217\235\240 \004)Tj /Span<>> BDC ( )Tj EMC (\201\005\004\b\217\210\005\001\005)Tj /T1_1 1 Tf 0.504 Tw 0 -1.218 TD (\212\035\016 \035\036\004\036\027\017\016 \023\024)Tj /Span<>> BDC ( )Tj EMC (\023\024\r\024\007\031 \030\036\022\021\024\006\036\035\036, \r)Tj /Span<>> BDC ( )Tj EMC (\021\024\n \004\017\f)Tj 0 Tw (-)Tj 0.634 Tw T* (\035\036 \215\217\037, \023\030\017\n\036\027\016\036\021\f\016 \030\016\ \007 \035\036\004\036\002\027\t\b \023\024\007\b\024\007\024\r. )Tj 0.122 Tw T* [(\204\036\007\017\022\026\n\036\027\021\024\027\024\036 )0.6(\035\036\004\036\027\017\036 )0.5(\023\030\036\023\026\030\026\021\026\n\017, )0.6(\030\036\020\031\035\017\030\031\033)]TJ 0 Tw (-)Tj 0.119 Tw T* (\013\017\n\017 \f\021\031\035, \n\024\032\036\021 \031\n\036\027\034\001\ \017\021\034 \r\t\030\026\032\036\027\027\024\f\021\034 \224\210\212, \027\ \024 )Tj 0.074 Tw T* (\027\036 \031\f\021\030\026\027\016\036\021 \026\027\026\021\024\n\017\004\ \036\f\022\017\005 \007\036\235\036\022\021. \236\f\023\024\035\034\024\ \r\026\027\017\036 )Tj 0.288 Tw T* (\r\026\020\017\027\026\035\034\027\t\b \023\036\f\f\026\030\017\036\r \027\ \036\007\024\f\021\026\021\024\004\027\024 \220\235\235\036\022\021\017\r\ \027\024. )Tj 0.106 Tw T* [(\225\021\017 \n\036\021\024\007\017\022\017 \030\036\022\024\n\036\027\007\ \031\033\021\f\016 )0.5(\023\030\017)]TJ /Span<>> BDC ( )Tj EMC (\023\030\024\021\017\r\024\023\024\022\026\026\027\017)Tj 0 Tw (-)Tj 0.163 Tw T* (\016\b \022)Tj /Span<>> BDC ( )Tj EMC (\024\023\036\030\026\021\017\r\027\024\n\031 \035\036\004\036\027\017\033\ [55\22657]. \203\026)Tj /Span<>> BDC ( )Tj EMC (\f\036\020\024\007\027\016\001)Tj 0 Tw (-)Tj 0.15 Tw T* (\027\017\005 \007\036\027\034 \024\f\027\024\r\027\t\n \n\036\021\024\007\ \024\n \035\036\004\036\027\017\016 \215\217\037 \016\r\035\016\036\021\f\ \016 )Tj 0 Tw T* (\b\017\030\031\030\020\017\004\036\f\022\017\005 [58,59].)Tj /T1_2 1 Tf 0 -2.436 TD (\036\204\005\201\020\b\007\206\002\240\005 \207\005\b\217\235\240 \004\217\ \201\201\005\004\210\007\007 \201\005\004\b\217\210\005\001\005)Tj /T1_1 1 Tf 0.187 Tw 0 -1.218 TD [(\210\023\036\030\026\021\017\r\027\t\005 )0.6(\n\036\021\024\007)]TJ /Span<>> BDC ( )Tj EMC 8.758 0 Td [(\227 )0.5(\r\026\030\017\026\027\021 )0.5(\035\036\004\036\027\017\016, )0.6(\024\002\036\f\023\036\004\017)]TJ 0 Tw (-)Tj 0.017 Tw -8.758 -1.218 Td (\r\026\033\013\017\005 \031\f\021\030\026\027\036\027\017\036 \026\027\026\ \021\024\n\017\004\036\f\022\017\b \007\036\235\036\022\021\024\r, \031\n\ \036\027\034)Tj 0 Tw (-)Tj 0.125 Tw T* (\001\036\027\017\036 \r\t\030\026\032\036\027\027\024\f\021\017 \f\017\n\ \023\021\024\n\024\r \017)Tj /Span<>> BDC ( )Tj EMC (\031\035\031\004\001\036\027\017\036 \022\026\004\036)Tj 0 Tw (-)Tj 0.236 Tw T* (\f\021\r\026 \032\017\027\017. \210\023\017\f\026\027 \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\017\n\036\027\016\036\021\f\016 \r)Tj /Span<>> BDC ( )Tj EMC (\022\035\017\027\017\004\036\f\022\024\005 )Tj 0.022 Tw T* [(\023\030\026\022\021\017\022\036 \001\017\030\024\022\017\005 \f\023\036\ \022\021\030 )0.5(\r\026\030\017\026\027\021\024\r \r\024\f\f\021\026\027\024\r\035\036\027\ \017\016 )]TJ 0.256 Tw T* (\024\023\024\030\027\t\b \f\021\030\031\022\021\031\030 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\215\217\037, \022\026\022 \f)Tj /Span<>> BDC ( )Tj EMC (\017\f\023\024\035\034\024\r\026\027\017\036\n )Tj 0.065 Tw T* (\021\030\026\027\f-/\017\n\023\035\026\027\021\026\021\026, \026)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\032\036 \002\036 \027\036\020\024. \210\023\036\030\026\006\ \017\017 \023\030\024)Tj 0 Tw (-)Tj 0.061 Tw T* (\r\024\007\016\021\f\016 \f)Tj /Span<>> BDC ( )Tj EMC [(\017\f\023\024\035\034\024\r\026\027\017\036\n \r\026\020\017\027\026\035\ \034\027\t\b, )0.5(\021\030\026\027\f\026\027\026\035\034)]TJ 0 Tw (-)Tj 0.113 Tw T* (\027\t\b, \021\030\026\027\f\023\036\030\017\027\036\026\035\034\027\t\b\ \017)Tj /Span<>> BDC ( )Tj EMC (\026\002\007\024\n\017\027\026\035\034\027\t\b \007\024\f\021\031\023\024\ \r )Tj 0 Tw T* ([2,12,13,41,59\22661].)Tj /T1_2 1 Tf 0 -2.436 TD (\213\007\201\202\201\205\007\006\005\017\004\007\005 \204\217\235\255\217\ \235\240)Tj /T1_1 1 Tf 0.05 Tw 0 -1.218 TD [(\215\030\017 \027\036\220\235\235\036\022\021\017\r\027\024\f\021\017 )0.5(\022\024\027\f\036\030\r\026\021\017\r\027\024\020\024 \035\036\004\036\027\ \017\016 )0.5(\017\035\017 )]TJ 0.275 Tw T* (\027\026\004\017\n\024\020\024 \f\027\017\032\036\027\017\016 \022\026\004\ \036\f\021\r\026 \032\017\027\017 \027\026)Tj /Span<>> BDC ( )Tj EMC (\235\024\027\036 \026\022)Tj 0 Tw (-)Tj 0.093 Tw T* (\021\017\r\027\024\005 \f\017\n\023\021\024\n\026\021\017\022\017, \027\026\ )Tj /Span<>> BDC ( )Tj EMC (\023\036\030\r\t\005 \023\035\026\027 \r\t\b\024\007\017\021 \024\023\036\ )Tj 0 Tw (-)Tj 0.139 Tw T* (\030\026\021\017\r\027\t\005 \n\036\021\024\007 \031\f\021\030\026\027\036\ \027\017\016 \215\217\037 [58,62,63]. \213\007\017\027\024\005 )Tj 0.089 Tw T* (\021\026\022\021\017\022\017 \024\023\036\030\026\021\017\r\027\024\020\024\ \035\036\004\036\027\017\016 \032\036\027\013\017\027 \f)Tj /Span<>> BDC ( )Tj EMC (\215\230\210 \027\036 \f\031)Tj 0 Tw (-)Tj 0.059 Tw T* (\013\036\f\021\r\031\036\021. \200\007\024\002\026\r\024\022, \027\036 \024\ \023\030\036\007\036\035\036\027\t \022\024\027\036\004\027\t\036 \021\024\ \004\022\017, )Tj 0.138 Tw T* (\023\024)Tj /Span<>> BDC ( )Tj EMC (\022\024\021\024\030\t\n \f\035\036\007\031\036\021 \024\006\036\027\017\ \r\026\021\034 \017\f\b\024\007\t \017)Tj /Span<>> BDC ( )Tj EMC (\024\002\024\f\027\024\r\t)Tj 0 Tw (-)Tj 0.229 Tw T* (\r\026\021\034 \030\036\031\035\034\021\026\021\017\r\027\024\f\021\034\ \r\026\030\017\026\027\021\024\r \024\023\036\030\026\021\017\r\027\024\ \020\024 \035\036)Tj 0 Tw (-)Tj 0.244 Tw T* [(\004\036\027\017\016. )0.6(\214\017\021\036\030\026\021\031\030\027\t\036 )0.5(\007\026\027\027\t\036 )0.6(\024\002 )0.5(\024\021\007\036\035\034\027\t\b )0.5(\b\017\030\031\030)]TJ 0 Tw (-)Tj 0.199 Tw T* (\020\017\004\036\f\022\017\b \023\024\007\b\024\007\026\b \002\t\035\017\ \027\026\n\017 \017\031\004\036\027\t \027\026)Tj /Span<>> BDC ( )Tj EMC (\023\030\036\007\n\036\021 )Tj 0.356 Tw T* (\r\035\017\016\027\017\016 \(\031\035\031\004\001\036\027\017\036, \024\021\ \f\031\021\f\021\r\017\036 \017\n\036\027\036\027\017\005, \031\b\031\007\ )Tj 0 Tw (-)Tj 0.071 Tw T* (\001\036\027\017\036\) \027\026)Tj /Span<>> BDC ( )Tj EMC (\026\027\026\021\024\n\017\033 \030\036\022\021\024\r\026\020\017\027\026\ \035\034\027\024\005 \023\036\030\036\020\024\030\024\007\022\017 )Tj 0 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\f\017\n\023\021\024\n\026\021\017\022\031 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\215\217\037.)Tj /T1_2 1 Tf 23.244 64.543 Td (\n\005\017\b\002\020\215 \204\001\020\017\b\007\004\020)Tj /T1_1 1 Tf 0.384 Tw T* (\200)Tj /Span<>> BDC ( )Tj EMC 1.162 0 Td [(2022 )0.5(\020\024\007\031 )0.6(\024\023\031\002\035\017\022\024\r\026\027\024 )0.5(\017\f\f\035\036\007\024\r\026\027\017\036 )0.6(\220\235\235\036\022)]TJ 0 Tw (-)Tj 0.561 Tw -1.162 -1.218 Td [(\021\017\r\027\024\f\021\017 )0.5(\b\017\030\031\030\020\017\004\036\f\022\024\020\024 )0.5(\035\036\004\036\027\017\016 )0.6(\f\017\n\023\021\024\n\026\021\017\004\036)]TJ 0 Tw (-)Tj 0.64 Tw T* (\f\022\024\020\024 \215\217\037 \023\024\f\035\036 \002\036\031\f\023\036\ \001\027\t\b \022\024\027\f\036\030\r\026\021\017\r\027\t\b )Tj 0.503 Tw T* (\n\036\030\024\023\030\017\016\021\017\005. \202\r\021\024\030\t \023\030\ \024\r\036\035\017 \030\036\022\021\030\024\f\023\036\022\021\017\r\027\t\ \005 )Tj -0.029 Tw T* (\026\027\026\035\017 \n\036\007\017\006\017\027\f\022\017\b \022\026\030\ \021 215 \023\026\006\017\036\027\021\024\022, \023\036\030\036\027\036\f\ \001\017\b )Tj 0.414 Tw 0 -1.218 TD (\021\030\026\027\f\r\026\020\017\027\026\035\034\027\031\033 \022\024\030\ \030\036\022\006\017\033 \027\026\021\017\r\027\t\n\017 \021\022\026\027\ \016\n\017 )Tj 0.138 Tw 0 -1.218 TD (\f)Tj /Span<>> BDC ( )Tj EMC (\023\030\017\n\036\027\036\027\017\036\n \035\036\r\026\021\024\030\024\023\ \035\026\f\021\017\022\017. \207\024\035\034\001\017\027\f\021\r\024 \023\ \026)Tj 0 Tw (-)Tj 0.209 Tw T* (\006\017\036\027\021\024\022, \024\021\024\002\030\026\027\027\t\b \007\035\ \016 \024\023\036\030\026\006\017\017, \017\n\036\035\017 \215\217\037 I\ II )Tj 0.126 Tw T* (\f\021\036\023\036\027\017 \(\030\026\n\036\030 \007\036\023\024 \022\024\ \027\021\030\026\f\021\027\024\020\024 \r\036\013\036\f\021\r\026 \002\024\ \035\036\036 )Tj 0.227 Tw T* [(4 )0.5(\f\n )0.5(\023\030\017)]TJ /Span<>> BDC ( )Tj EMC 4.407 0 Td [(\007\036\235\036\022\024\020\030\026\235\017\017\), )0.6(\f\024\020\035\026\f\027\024 )0.6(\022\035\026\f\f\017\235\017\022\026\006\017\017 )]TJ 0.185 Tw -4.407 -1.218 Td (\215\217\037 \023\024)Tj /Span<>> BDC ( )Tj EMC (\r\t\030\026\032\036\027\027\024\f\021\017 \030\036\027\021\020\036\027\024\ \035\024\020\017\004\036\f\022\017\b \017\n\036\027\036)Tj 0 Tw (-)Tj 0.31 Tw 0 -1.218 TD (\027\017\005. \232\026\f\021\024\021\026 \020\024\f\023\017\021\026\035\034\ \027\t\b \024\f\035\024\032\027\036\027\017\005 \f\024\f\021\026\r\017\035\ \026 )Tj 0.062 Tw 0 -1.218 TD (11,2%, \027\026\017\002\024\035\036\036 \004\026\f\021\024\005 \002\t\035\ \026 \026\007\036\030\032\022\026 \n\024\004\017 \(8,4%\). )Tj 0.202 Tw 0 -1.218 TD (\224\030\036\007\027\016\016 \023\030\024\007\024\035\032\017\021\036\035\ \034\027\024\f\021\034 \027\026\002\035\033\007\036\027\017\016 \f\024\f\ \021\026\r\017\035\026 )Tj 0.065 Tw T* (12,7 \n\036\f\016\006\026 \(\f\021\026\027\007\026\030\021\027\024\036 \024\ \021\022\035\024\027\036\027\017\036 13,9, \007\017\026\023\026\024\027\ )Tj 0.043 Tw T* [(1,4\22671,5 \n\036\f\016\006\036\r\), )0.5(\023\030\017)]TJ /Span<>> BDC ( )Tj EMC [(\220\021\024\n )0.5(\031\035\031\004\001\036\027\017\036 )0.5(\002\t\035\024 \026\030\036\020\017)]TJ 0 Tw (-)Tj 0.07 Tw T* (\f\021\030\017\030\024\r\026\027\024 \r)Tj /Span<>> BDC ( )Tj EMC (87,9% \f\035\031\004\026\036\r. \200)Tj /Span<>> BDC ( )Tj EMC (80% \f\035\031\004\026\036\r \r)Tj /Span<>> BDC ( )Tj EMC (\022\024\027\006\036 )Tj 0.132 Tw T* (\023\036\030\017\024\007\026 \027\026\002\035\033\007\036\027\017\016 \024\ \021\f\031\021\f\021\r\024\r\026\035\017 \023\030\017\027\026\022\017 \030\ \036\006\017)Tj 0 Tw (-)Tj 0.02 Tw T* (\007\017\r\026 \215\217\037. \215\024\035\024\032\017\021\036\035\034\027\ \026\016 \007\017\027\026\n\017\022\026 \224\210\212 \002\t\035\026 \r)Tj /Span<>> BDC ( )Tj EMC (58% )Tj 0.219 Tw T* (\f\035\031\004\026\036\r [64]. \203\036\f\n\024\021\030\016 \027\026)Tj /Span<>> BDC ( )Tj EMC (\021\024, \004\021\024 \r)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\n, \026)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\032\036 )Tj 0.144 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\030\016\007\036 \007\030\031\020\017\b \017\f\f\035\036\007\024\r\026\027\ \017\005, \r)Tj /Span<>> BDC ( )Tj EMC (\030\026\027\027\036\n \023\024\f\035\036\024\023\036\030\026)Tj 0 Tw (-)Tj 0.009 Tw T* (\006\017\024\027\027\024\n \023\036\030\017\024\007\036 \002\t\035\017 \024\ \021\n\036\004\036\027\t \031\n\036\027\034\001\036\027\017\036 \026\027\ \026\021\024)Tj 0 Tw (-)Tj -0.033 Tw T* (\n\017\004\036\f\022\024\020\024 \007\036\235\036\022\021\026, \f\027\017\ \032\036\027\017\036 \023\030\024\016\r\035\036\027\017\016 \f\017\n\023\ \021\024\n\024\r )Tj 0.212 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\031\035\031\004\001\036\027\017\036 \022\026\004\036\f\021\r\026 \032\017\ \027\017 \023\026\006\017\036\027\021\024\022 \007\024)Tj /Span<>> BDC ( )Tj EMC (\031\030\024\r\027\016 )Tj 0.206 Tw T* [(\020\030\031\023\023\t \022\024\027\021\030\024\035\016, \027\036 \r\023\ \024\035\027\036 )0.5(\016\f\036\027 \n\036\b\026\027\017\n )0.5(\030\036\022\024\027)]TJ 0 Tw (-)Tj T* (\f\021\030\031\022\021\017\r\027\024\020\024 \007\036\005\f\021\r\017\016\ \024\023\036\030\026\006\017\005 [48,65,66].)Tj /T1_2 1 Tf 0 -2.436 TD (\033\020\204\020\201\217\017\004\217\204\007\006\005\017\004\020\215 \017\ \020\004\201\217\004\217\001\203\204\217\204\005\201\007\002\005\217\204\ \005\004\017\007\215)Tj /T1_1 1 Tf 0.453 Tw 0 -1.218 TD (\200\035\017\016\027\017\036 \035\026\023\026\030\024\f\022\024\023\017\004\ \036\f\022\024\005 \f\026\022\030\024\022\024\035\034\023\024\023\036\030\ \017\027\036\024)Tj /Span<>> BDC (-)Tj EMC 0.197 Tw T* (\023\036\022\f\017\017 \027\026)Tj /Span<>> BDC ( )Tj EMC (\f\021\030\031\022\021\031\030\031 \003\224\200 \017)Tj /Span<>> BDC ( )Tj EMC (\224\210\212 \024\f\r\036\013\036\027\024 \r)Tj /Span<>> BDC ( )Tj EMC (\017\f\f\035\036)Tj 0 Tw (-)Tj 0.228 Tw T* (\007\024\r\026\027\017\017, \r\022\035\033\004\026\r\001\036\n 132 \f\035\ \031\004\026\016 [67] \f)Tj /Span<>> BDC ( )Tj EMC (\n\036\007\017\026\027\024\005 )Tj 0.301 Tw T* (\027\026\002\035\033\007\036\027\017\016 12,5 \n\036\f\016\006\036\r. \200\ )Tj /Span<>> BDC ( )Tj EMC (\030\036\031\035\034\021\026\021\036 \024\023\036\030\026\006\017\017 )Tj 0.129 Tw T* (\031\035\031\004\001\017\035\026\f\034 \f\021\030\031\022\021\031\030\026\ \003\224\200 \r)Tj /Span<>> BDC ( )Tj EMC (91,7%, \023\030\024\016\r\035\036\027\017\016 \224\210\212 )Tj 0.032 Tw T* (\031\n\036\027\034\001\017\035\017\f\034 \r)Tj /Span<>> BDC ( )Tj EMC (42%, \026)Tj /Span<>> BDC ( )Tj EMC (\031 5% \023\026\006\017\036\027\021\024\022 \f\017\n\023\021\024\n\t, \027\ \026)Tj 0 Tw (-)Tj T* (\024\002\024\030\024\021, \023\024\016\r\017\035\017\f\034.)Tj 0.142 Tw T* [(\224\024\020\035\026\f\027\024 \007\026\027\027\t\n \007\030\031\020\017\ \b )0.5(\026\r\021\024\030\024\r, \f\021\026\007\017\016 )0.5(POP-Q \003\224\200 )]TJ 0.04 Tw T* (\(Bp\) \031\035\031\004\001\017\035\026\f\034, \004\026\f\021\024\021\026\ \030\036\006\017\007\017\r\024\r \f\024\f\021\026\r\017\035\026 2,2%. )Tj 0.213 Tw T* [(\240\036\027\013\017\027\t )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC [(\030\036\006\017\007\017\r\024\n )0.5(\027\036 \027\031\032\007\026\035\017\f\034 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC (\023\024\r\021\024\030\027\024\n )Tj 0.071 Tw T* (\r\n\036\001\026\021\036\035\034\f\021\r\036. \210\021\n\036\004\036\027\ \024 \031\f\031\020\031\002\035\036\027\017\036 \224\210\212 \023\024)Tj /Span<>> BDC ( )Tj EMC (\024\002\013\036)Tj 0 Tw (-)Tj -0.011 Tw T* (\n\031 \002\026\035\035\031 CRAD-8, \b\024\021\016 \027\036 \002\t\035\024\ \017\n\036\027\036\027\017\005 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\024\006\036\027\022\036 )Tj 0.277 Tw T* (\023\024)Tj /Span<>> BDC ( )Tj EMC [(\024\023\030\024\f\027\017\022\031 Col)30(or)-24(ec)-16(t)15(al-Anal Im)10.1(p)32(a)-17(c)-16(t Q)-16(uest)-31.9(ionnair)-24(e )]TJ 0.097 Tw T* [(\(CRAIQ\) )0.6([13,68,69]. )0.5(\214\026\023\026\030\024\f\022\024\023\017\004\036\f\022\017\005 )0.6(\007\024\f\021\031\023 )0.5(\022)]TJ /Span<>> BDC ( )Tj EMC 20.79 0 Td (\023\036)Tj 0 Tw (-)Tj 0.1 Tw -20.79 -1.218 Td (\030\036\007\027\036\n\031 \017)Tj /Span<>> BDC ( )Tj EMC (\026\007\027\036\n\031 \022\024\n\023\026\030\021\n\036\027\021\031 \023\ \024\r\024\035\016\036\021 \f\024\007\026\021\034 )Tj 0.429 Tw T* [(\007\031\023\035\017\022\026\021\031\030\t \235\026\f\006\017\017 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC (\030\036\022\024\027\f\021\030\031\022\006\017\033 \f\021\030\031\022\021\ \031\030\t )Tj 0.042 Tw T* ([34,35,70]. \200)Tj /Span<>> BDC ( )Tj EMC (\024\002\024\030\036 \216\017\021\026\030\034\016\027 \202.\206. \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. \023\030\024\r\036\007\036\027 )Tj 0.074 Tw T* (\026\027\026\035\017 \220\235\235\036\022\021\017\r\027\024\f\021\017 \017\ )Tj /Span<>> BDC ( )Tj EMC (\002\036\024\023\026\f\027\024\f\021\017 \n\036\021\024\007\026 \035\026\ \023\026)Tj 0 Tw (-)Tj 0.301 Tw T* (\030\024\f\022\024\023\017\004\036\f\022\024\005 \r\036\027\021\030\026\035\ \034\027\024\005 \030\036\022\021\024\023\036\022\f\017\017 \f\036\021\004\ \026\021\t\n )Tj 0.291 Tw T* (\017\n\023\035\026\027\021\024\n. \236)Tj /Span<>> BDC ( )Tj EMC (2101 \r\022\035\033\004\036\027\027\024\020\024 \r)Tj /Span<>> BDC ( )Tj EMC (\017\f\f\035\036\007\024\r\026\027\017\036 )Tj 0.271 Tw T* [(\023\030\024\024\023\036\030\017\030\024\r\026\027\027\024\020\024 )0.5(\023\026\006\017\036\027\021\026 \(\f\024 \f\030\036\007\027\017\n \r\024\ \030\026\f)]TJ 0 Tw (-)Tj 0.376 Tw T* (\021\024\n 62,1 \020\024\007\026\) \030\036\006\017\007\017\r \026\002\024\ \035\036\r\026\027\017\016 \027\026\002\035\033\007\026\035\f\016 )Tj 0.084 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (4,1% \f\035\031\004\026\036\r. \003\027\026\004\017\021\036\035\034\027\024\ \036 \031\035\031\004\001\036\027\017\036 \f\017\n\023\021\024\n\024\r )Tj 0.097 Tw T* (\024\002\f\021\030\031\022\021\017\r\027\024\005 \007\036\235\036\022\026\ \006\017\017 \024\021\n\036\004\036\027\024 \r)Tj /Span<>> BDC ( )Tj EMC (79,6% \027\026\002\035\033)Tj 0 Tw (-)Tj T* (\007\036\027\017\005 [53].)Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\206)10(\002\036\033 \035\030\032\003\033)30(\n)42(\032)-21(\230\033\241)]TJ 57.136 0 Td (REVIEW)Tj /T1_3 1 Tf 25 0 0 25 504.6646 56.0378 Tm (191)Tj ET endstream endobj 68 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 69 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 70 0 obj <>/ExtGState<>/Font<>/ProcSet[/PDF/Text]/Properties<>/Shading<>/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 71 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 72 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 897 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.066 Tw 10 0 0 10 70.8661 724.8299 Tm (\215\230\210 \f\030\036\007\017 \032\036\027\013\017\027 \217\200 \(484 \ \023\026\006\017\036\027\021\022\017, \f\030\036\007\027\017\005 \r\024\ )Tj 0 Tw (-)Tj 0.107 Tw 0 -1.218 TD (\030\026\f\021)Tj /Span<>> BDC ( )Tj EMC (\227 34,05)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (6,91 \035\036\021\). \215\024)Tj /Span<>> BDC ( )Tj EMC (\007\026\027\027\t\n \020\017\027\036\022\024\035\024\020\017\004\036)Tj 0 Tw (-)Tj 0.193 Tw T* (\f\022\024\020\024 \024\f\n\024\021\030\026 \f\235\024\030\n\017\030\024\ \r\026\027\t \020\030\031\023\023\t: \024\f\027\024\r\027\026\016)Tj /Span<>> BDC ( )Tj EMC (\227 )Tj 0.048 Tw T* (118 \004\036\035. \(25%\) \f)Tj /Span<>> BDC ( )Tj EMC (\023\030\017\027\026\022\026\n\017 \215\230\210 \023\024)Tj /Span<>> BDC ( )Tj EMC (\022\035\026\f\f\017\235\017\022\026\006\017\017 )Tj 0.223 Tw T* [(POP-Q, )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC 4.1 0 Td (\022\024\027\021\030\024\035\016)Tj /Span<>> BDC ( )Tj EMC 4.256 0 Td [(\227 )0.5(366 )0.5(\004\036\035. )0.6(\(75%\))]TJ /Span<>> BDC ( )Tj EMC 8.529 0 Td [(\227 )0.5(\002\036 )0.6(\215\230\210. )]TJ 0.348 Tw -16.885 -1.218 Td (\217\026\f\023\030\036\007\036\035\036\027\017\036 \f\021\026\007\017\005\ \215\230\210 \023\024)Tj /Span<>> BDC ( )Tj EMC (POP-Q \r)Tj /Span<>> BDC ( )Tj EMC (\024\f\027\024\r\027\024\005 )Tj 0.176 Tw 0 -1.218 TD (\020\030\031\023\023\036 \024\022\026\026\035\024\f\034 \021\026\022\017\ \n: I)Tj /Span<>> BDC ( )Tj EMC (\227 31,03% II)Tj /Span<>> BDC ( )Tj EMC (\227 43,12%, )Tj -0.018 Tw 0 -1.218 TD (III)Tj /Span<>> BDC ( )Tj EMC 1.337 0 Td [(\227 22,41%, )0.5(IV)]TJ /Span<>> BDC ( )Tj EMC [(\227 )0.5(3,44%. )0.5(\224\030\036\007\027\036\036 )0.5(\022\024\035\017\004\036\f\021\r\024 \030\024\007\024\r )]TJ -0.022 Tw -1.337 -1.218 Td (\r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\026\b \002\t\035\024 1,67)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (0,66 \017)Tj /Span<>> BDC ( )Tj EMC (0,73)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (0,34, \f\024\024\021\r\036\021\f\021\r\036\027)Tj 0 Tw (-)Tj 0.061 Tw T* (\027\024, \026\002\024\030\021\024\r)Tj /Span<>> BDC ( )Tj EMC (\227 1,29)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (1,56 \017)Tj /Span<>> BDC ( )Tj EMC (0,58)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (0,13. \224\030\036\007\027\017\005 \030\036)Tj 0 Tw (-)Tj 0.044 Tw T* (\031\035\034\021\026\021 \023\024)Tj /Span<>> BDC ( )Tj EMC (\024\023\030\024\f\027\017\022\031 PFDI-20 \024\022\026\026\035\f\016 7\ 5,73)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (37,67 )Tj 0.287 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (31,99)Tj /Span<>> BDC ( )Tj EMC 3.742 0 Td (\261)Tj /Span<>> BDC ( )Tj EMC [(7,26, )0.5(\f\024\024\021\r\036\021\f\021\r\036\027\027\024. )0.5(\025\036\f\026\030\036\r\024 )0.5(\f\036\004\036\027\017\036 )]TJ 0.063 Tw -3.742 -1.218 Td (\r)Tj /Span<>> BDC ( )Tj EMC 0.77 0 Td [(\026\027\026\n\027\036\036 )0.5(\002\t\035\024 )0.5(\021\024\035\034\022\024 )0.5(\031)]TJ /Span<>> BDC ( )Tj EMC [(\023\026\006\017\036\027\021\024\022 )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC 15.697 0 Td [(I )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 1.483 0 Td [(II )0.5(\f\021\026\007\017\016)]TJ 0 Tw (-)Tj 0.03 Tw -17.95 -1.218 Td (\n\017 \215\230\210, \026)Tj /Span<>> BDC ( )Tj EMC (\031 \023\026\006\017\036\027\021\024\022 \f\024 II \f\021\026\007\017\036\ \005)Tj /Span<>> BDC ( )Tj EMC (\227 \017\f\022\035\033\004\017\021\036\035\034)Tj 0 Tw (-)Tj 0.177 Tw T* (\027\024 \031)Tj /Span<>> BDC ( )Tj EMC [(\023\024\r\021\024\030\027\024\030\024\007\016\013\017\b. )0.5(\215\024\035\024\032\017\021\036\035\034\027\024 \022\024\030\030\036\035\ \017\030\031\036\021 )]TJ 0.12 Tw T* (\f\021\026\007\017\016 \215\230\210 \f)Tj /Span<>> BDC ( )Tj EMC (\022\024\035\017\004\036\f\021\r\024\n \030\024\007\024\r. \211)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\022 \f)Tj /Span<>> BDC ( )Tj EMC (\021\016)Tj 0 Tw (-)Tj 0.136 Tw T* (\032\036\035\t\n\017 \235\024\030\n\026\n\017 \215\230\210 \024\021\n\036\ \004\036\027\t \021\024\035\034\022\024 \030\024\007\t \004\036\030\036\ )Tj 0.089 Tw T* [(\036\f\021\036\f\021\r\036\027\027\t\036 )0.5(\030\024\007\024\r\t\036 \023\031\021\017. )0.5(\210\006\036\027\022\017 )0.5(\023\024)]TJ /Span<>> BDC ( )Tj EMC [(PFDI-20 )0.5(\f\021\026)]TJ 0 Tw (-)Tj 0.126 Tw T* (\021\017\f\021\017\004\036\f\022\017 \027\036 \030\026\035\017\004\026\035\ \017\f\034 \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\022 \f)Tj /Span<>> BDC ( )Tj EMC (I \f\021\026\007\017\036\005 )Tj -0.021 Tw T* [(\215\230\210 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 2.559 0 Td [(\020\030\031\023\023\024\005 )0.5(\022\024\027\021\030\024\035\016 )0.6([4]. )0.5(\224\b\024\032\017\036 )0.6(\007\026\027\027\t\036 )0.5(\023\031\002\035\017\022\031)]TJ 0 Tw (-)Tj -2.559 -1.218 Td (\036\021 \030\016\007 \026\r\021\024\030\024\r [12\22618].)Tj 0.227 Tw T* (\205\026\022\021\024\030\024\n \030\017\f\022\026 \215\230\210 \031)Tj /Span<>> BDC ( )Tj EMC (\032\036\027\013\017\027 \217\200 \016\r\035\016\033\021\f\016 \r\026\020\ \017)Tj 0 Tw (-)Tj 0.232 Tw T* [(\027\026\035\034\027\t\036 )0.6(\030\024\007\t )0.5(\002\036 )0.5(\235\017\017\004\036\f\022\024\005 )0.6(\030\036\026\002\017\035\017\021\026\006\017\017, )0.5(\024\f\024)]TJ 0 Tw (-)Tj 0.265 Tw T* (\002\036\027\027\024 \022\030\031\023\027\t\n \023\035\024\007\024\n. \200\ )Tj /Span<>> BDC ( )Tj EMC (\023\030\036\n\036\027\024\023\026\031\026\035\034\027\024\n \023\036)Tj 0 Tw (-)Tj 0.09 Tw T* (\030\017\024\007\036 \002\024\035\036\036 \r\026\032\027\t\n \f\021\026\027\ \024\r\017\021\f\016 \024\032\017\030\036\027\017\036 [19\22621]. )Tj 0.278 Tw T* (\225\023\017\017\024\021\024\n\017\016 \021\026\022\032\036 \016\r\035\016\ \036\021\f\016 \023\030\024\r\024\006\017\030\031\033\013\017\n \215\217\ \037 )Tj 0.154 Tw T* (\235\026\022\021\024\030\024\n [22]. \200\024\030\026\f\021, \007\017\f\ \023\035\026\017\016 \f\024\036\007\017\027\017\021\036\035\034\027\024\ \005 )Tj 0.137 Tw T* (\021\022\026\027\017 \027\036\020\026\021\017\r\027\024 \r\035\017\016\033\ \021 \027\026)Tj /Span<>> BDC ( )Tj EMC (\f\024\f\021\024\016\027\017\036 \023\030\024\n\036\032\027\024\f\021\017\ )Tj 0 Tw T* ([19,23\22628].)Tj 0.249 Tw T* (\224\024\b\030\026\027\016\036\021\f\016 \027\036\024\007\027\024\027\026\ \004\027\024\f\021\034 \r\020\035\016\007\024\r \027\026)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\r\017\004)Tj 0 Tw (-)Tj 0.217 Tw T* [(\027\024\f\021\034 )0.6(\035\017\002\024 )0.5(\224\210\212, )0.5(\035\017\002\024 )0.5(\215\217\037 )0.5([29\22632], )0.6(\022\026\022 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 18.77 0 Td [(\027\026 )0.5(\030\024\035\034 )]TJ 0.328 Tw -18.77 -1.218 Td (\020\030\026\007\017\036\027\021\026 \030\036\022\021\026\035\034\027\024\ -\r\035\026\020\026\035\017\013\027\024\020\024 \007\026\r\035\036\027\017\ \016 [33]. )Tj 0.131 Tw T* (\217\016\007 \026\r\021\024\030\024\r \007\035\016 \024\002\024\027\026\ \004\036\027\017\016 \023\031\t\030\027\024-\r\026\020\017\027\026\035\034\ \027\024\005 )Tj 0.071 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC [(\030\036\022\021\024-\r\026\020\017\027\026\035\034\027\024\005 )0.5(\023\036\030\036\020\024\030\024\007\024\022 \017\f\023\024\035\034\031\ \033 \021\036\030\n\017)]TJ 0 Tw (-)Tj 0.123 Tw T* (\027\t \253\023\036\030\036\007\027\017\005 \017)Tj /Span<>> BDC ( )Tj EMC (\026\007\027\017\005 \022\024\n\023\026\030\021\n\036\027\021\273, \023\ \024\007\004\036\030\022\017\r\026\016 )Tj 0.281 Tw T* (\f\035\024\032\027\024\f\021\034 \026\027\026\021\024\n\017\017 [34,35].\ \200)Tj /Span<>> BDC ( )Tj EMC (\006\036\035\024\n, \215\230\210 \f\035\036\007\031)Tj 0 Tw (-)Tj 0.276 Tw T* [(\036\021 \f\004\017\021\026\021\034 \023\024\035\017\220\021\017\024\035\ \024\020\017\004\027\t\n )0.5(\f\024\f\021\024\016\027\017\036\n )0.5([36\22640], )]TJ 0.333 Tw T* [(\004\021\024 )0.5(\007\017\022\021\031\036\021 )0.6(\027\036\024\002\b\024\007\017\n\024\f\021\034 )0.5(\007\017\235\235\036\030\036\027\006\017\030\024\r\026\027\027\024\020\024\ )]TJ 0 Tw T* (\023\024\007\b\024\007\026.)Tj /T1_1 1 Tf -0.033 Tw 0 -2.436 TD [(\n\005\b\217\235\240 \217\210\005\002\004\007 \206\240\201\020\212\005\002\ \002\217\017\b\007 )0.5(\204\201\217\001\020\204\017\020 \b\020\217\206\240\255 )]TJ 0 Tw 0 -1.218 TD (\217\201\205\020\002\217\206 \007)Tj /Span<>> BDC ( )Tj EMC (\201\005\004\b\217\210\005\001\005)Tj /T1_0 1 Tf 0.149 Tw T* [(\236\r\036\f\021\027\t \027\036\f\022\024\035\034\022\024 )0.5(\n\036\021\024\007\017\022 \024\006\036\027\022\017 \r\t\030\026\032\036\ \027\027\024\f\021\017 )]TJ 0.212 Tw T* (\215\230\210 \031)Tj /Span<>> BDC ( )Tj EMC (\032\036\027\013\017\027: \022\035\026\f\f\017\235\017\022\026\006\017\016\ \204\026\035\017\027\024\r\f\022\024\020\024)Tj /Span<>> BDC ( )Tj EMC (\204.\224., )Tj 0.138 Tw T* [(Baden\226W)12(alk)10(er \017)]TJ /Span<>> BDC ( )Tj EMC (P\210P-Q. \210\002\013\036\023\030\017\027\016\021\026\016 \027\026)Tj /Span<>> BDC ( )Tj EMC (\f\036\020\024\007\027\016\001)Tj 0 Tw (-)Tj 0.272 Tw T* (\027\017\005 \007\036\027\034 \f\017\f\021\036\n\026 POP-Q \023\024\r\024\ \035\016\036\021 \022\024\035\017\004\036\f\021\r\036\027\027\024 )Tj 0.058 Tw T* (\024\006\036\027\017\021\034 \023\030\024\035\026\023\f \f\021\036\027\024\ \022 \r\035\026\020\026\035\017\013\026 \023\031\021\036\n \017\n\036\030\ \036\027\017\016 )Tj -0.011 Tw T* (9 \035\017\027\036\005\027\t\b \r\036\035\017\004\017\027. \202\027\026\021\ \024\n\017\004\036\f\022\026\016 \023\024\017\006\017\016 6 \021\024\004\ \036\022 )Tj 0.001 Tw T* (\(\202\026, \200\026, \202\030, \200\030, \224, D\) \017\n\036\030\016\036\ \021\f\016 \r)Tj /Span<>> BDC ( )Tj EMC (\023\024\035\024\032\017\021\036\035\034\027\t\b \017\035\017 )Tj 0.303 Tw T* (\024\021\030\017\006\026\021\036\035\034\027\t\b \027\026\004\036\027\017\ \016\b \024\021 \031\030\024\r\027\016 \020\017\n\036\027\026\035\034\027\ \024\020\024 )Tj 0.153 Tw T* [(\022\024\035\034\006\026. \210\f\021\026\035\034\027\t\036 3 \023\026\030\ \026\n\036\021\030\026 \(T)-52(VL, GH, PB\) \017\n\036)]TJ 0 Tw (-)Tj 0.085 Tw T* (\030\016\033\021\f\016 \r)Tj /Span<>> BDC ( )Tj EMC (\026\002\f\024\035\033\021\027\t\b \r\036\035\017\004\017\027\026\b. \203\ \026)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\036\007\027\036\005 \f\021\036\027)Tj 0 Tw (-)Tj 0.158 Tw T* (\022\036 \r\035\026\020\026\035\017\013\026 \024\021\n\036\004\026\036\021\ \f\016 \030\026\f\023\024\035\024\032\036\027\017\036 \f\035\036\007\031\ \033\013\017\b )Tj 0 Tw T* (\021\024\004\036\022:)Tj 0.255 Tw 23.244 64.543 Td (\243)Tj /Span<>> BDC [( )-12( )]TJ EMC 1 0 Td [(\202\026, \024\023\030\036\007\036\035\016\033\013\026\016\f\016 )0.5(\023\024)]TJ /Span<>> BDC ( )Tj EMC (\f\030\036\007\027\036\005 \035\017\027\017\017 \027\026)Tj /Span<>> BDC ( )Tj EMC (3)Tj /Span<>> BDC ( )Tj EMC (\f\n )Tj 0.081 Tw T* (\023\030\024\022\f\017\n\026\035\034\027\036\036 \027\026\030\031\032\027\ \024\020\024 \024\021\r\036\030\f\021\017\016 \031\030\036\021\030\t, \023\ \030\024)Tj 0 Tw (-)Tj 0.047 Tw T* [(\036\022\006\017\016 )0.5(\031\030\036\021\030\024-\r\036\017\022\026\035\034\027\024\020\024 )0.6(\f\036\020\n\036\027\021\026. )0.6(\200)]TJ /Span<>> BDC ( )Tj EMC 16.806 0 Td [(\027\024\030\n\036 )0.5(\024\027\026 )]TJ -0.007 Tw -16.806 -1.218 Td (\f\024\024\021\r\036\021\f\021\r\031\036\021 -3 \f\n, \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\r\t\030\026\032\036\027\027\024\n \023\030\024\035\026\023\f\036 \007\024\ )Tj 0 Tw (-)Tj T* (\f\021\017\020\026\036\021 +3 \f\n.)Tj -0.019 Tw -1 -1.218 Td (\243)Tj /Span<>> BDC [( )-286( )]TJ EMC 1 0 Td (\200\026)Tj /Span<>> BDC ( )Tj EMC (\227 \027\026\017\002\024\035\036\036 \007\017\f\021\026\035\034\027\024\ \030\026\f\023\024\035\024\032\036\027\027\026\016 \023\024\017\006\017\ \016 )Tj 0.029 Tw 0 -1.218 TD (\035\033\002\024\005 \004\026\f\021\017 \023\036\030\036\007\027\036\005\ \f\021\036\027\022\017 \r\035\026\020\026\035\017\013\026 \024\021 \001\ \036\005\022\017 )Tj 0 Tw 0 -1.218 TD (\n\026\021\022\017 \017\035\017 \022\031\023\024\035\026 \r\035\026\020\026\ \035\017\013\026 \(\021\024\004\022\026 \224\) \007\024)Tj /Span<>> BDC ( )Tj EMC (\021\024\004\022\017 \202\026. )Tj 0.001 Tw T* (\200)Tj /Span<>> BDC ( )Tj EMC (\027\024\030\n\036 \021\024\004\022\026 \200\026 \027\026\b\024\007\017\021\ \f\016 \027\026)Tj /Span<>> BDC ( )Tj EMC (\030\026\f\f\021\024\016\027\017\017)Tj /Span<>> BDC ( )Tj EMC (\227 3)Tj /Span<>> BDC ( )Tj EMC (\f\n, )Tj 0.13 Tw T* (\026)Tj /Span<>> BDC ( )Tj EMC (\023\030\017 IV \f\021\026\007\017\017 \215\230\210 POP-Q \017\n\036\036\ \021 \023\024\035\024\032\017\021\036\035\034\027\024\036 )Tj 0 Tw T* (\027\026\004\036\027\017\036, \030\026\r\027\024\036 \007\035\017\027\036\ \r\035\026\020\026\035\017\013\026.)Tj 0.341 Tw -1 -1.218 Td (\243)Tj /Span<>> BDC [( )74( )]TJ EMC 1 0 Td (\224)Tj /Span<>> BDC ( )Tj EMC 1.04 0 Td [(\227 )0.5(\027\026\017\002\024\035\036\036 )0.6(\007\017\f\021\026\035\034\027\024 )0.5(\030\026\f\023\024\035\024\032\036\027\027\026\016 )0.6(\004\026\f\021\034 )]TJ 0 Tw -1.04 -1.218 Td (\001\036\005\022\017 \n\026\021\022\017/\022\031\023\024\035\026 \r\035\026\ \020\026\035\017\013\026.)Tj 0.086 Tw -1 -1.218 Td [(\203\026 )0.5(\026\007\027\036\005 )0.6(\f\021\036\027\022\036 )0.5(\r\035\026\020\026\035\017\013\026 )0.5(\024\021\n\036\004\026\036\021\f\016 )0.6(\030\026\f\023\024\035\024\032\036)]TJ 0 Tw (-)Tj T* (\027\017\036 \f\035\036\007\031\033\013\017\b \021\024\004\036\022:)Tj -0.002 Tw T* (\243)Tj /Span<>> BDC [( )-269( )]TJ EMC 1 0 Td (\202\030)Tj /Span<>> BDC ( )Tj EMC (\227 \023\024)Tj /Span<>> BDC ( )Tj EMC (\f\030\036\007\027\036\005 \035\017\027\017\017 \027\026)Tj /Span<>> BDC ( )Tj EMC (3 \f\n \023\030\024\022\f\017\n\026\035\034\027\036\036 \020\017)Tj 0 Tw (-)Tj T* (\n\036\027\026\035\034\027\024\020\024 \022\024\035\034\006\026.)Tj 0.187 Tw -1 -1.218 Td (\243)Tj /Span<>> BDC [( )-80( )]TJ EMC 1 0 Td (\200\030)Tj /Span<>> BDC ( )Tj EMC (\227 \023\024)Tj /Span<>> BDC ( )Tj EMC (\026\027\026\035\024\020\017\017 \f)Tj /Span<>> BDC ( )Tj EMC (\202\030, \f\024\024\021\r\036\021\f\021\r\031\036\021 \027\026\017\002\024\ \035\036\036 )Tj 0.099 Tw T* (\007\017\f\021\026\035\034\027\024 \030\026\f\023\024\035\024\032\036\027\ \027\024\005 \021\024\004\022\036 \035\033\002\024\005 \004\026\f\021\017\ \003\224\200 )Tj 0 Tw T* (\024\021 \001\036\005\022\017 \n\026\021\022\017/\022\031\023\024\035\026\ \r\035\026\020\026\035\017\013\026.)Tj -1 -1.218 Td (\243)Tj /Span<>> BDC [( )-267( )]TJ EMC 1 0 Td (D)Tj /Span<>> BDC ( )Tj EMC (\227 \026\007\027\017\005 \f\r\024\007, \020\035\031\002\017\027\026.)Tj 0.269 Tw -1 -1.218 Td (\243)Tj /Span<>> BDC [( )2( )]TJ EMC 1 0 Td [(\215\026\030\026\n\036\021\030 T)-52(VL \024\023\017\f\t\r\026\036\021 \024\002\013\031\033 \007\035\017\027\031\ \r\035\026\020\026\035\017)]TJ 0 Tw (-)Tj 0.033 Tw T* [(\013\026, )0.6(GH)]TJ /Span<>> BDC ( )Tj EMC 3.004 0 Td [(\227 )0.6(\007\035\017\027\031 )0.6(\023\024\035\024\r\024\005 )0.5(\013\036\035\017, )0.6(\026)]TJ /Span<>> BDC ( )Tj EMC 11.024 0 Td (PB)Tj /Span<>> BDC ( )Tj EMC 1.322 0 Td [(\227 )0.6(\007\035\017\027\031 )0.6(\021\036\035\026 )]TJ 0 Tw -15.35 -1.218 Td (\023\030\024\n\036\032\027\024\f\021\017.)Tj 0.014 Tc 0.59 Tw -1 -1.218 Td (\224\021\026\007\017\030\024\r\026\027\017\036 \023\024)Tj /Span<>> BDC ( )Tj EMC [(\f\017\f\021\036\n\036 POP-Q \023\030\024\017\r\024\007\017\021\f\016)14( )]TJ 0.123 Tw T* (\023\024)Tj /Span<>> BDC ( )Tj EMC (\027\026\017\002\024\035\036\036 \007\017\f\021\026\035\034\027\024 \030\ \026\f\023\024\035\024\032\036\027\027\024\005 \004\026\f\021\017 \r\035\ \026)Tj 0 Tc 0 Tw (-)Tj 0.014 Tc 0.255 Tw T* [(\020\026\035\017\013\027\024\005 \f\021\036\027\022\017 \(\007\017\f\021\ \026\035\034\027\024\n\031 \022\024\n\023\024\027\036\027\021\031 \215\230\ \210\):)14( )]TJ 0.012 Tw T* (I)Tj /Span<>> BDC ( )Tj EMC (\227 \007\017\f\021\026\035\034\027\t\005 \022\024\n\023\024\027\036\027\ \021 \002\024\035\036\036 \004\036\n \027\026)Tj /Span<>> BDC ( )Tj EMC [(1 \f\n \r\t\001\036)14.1( )]TJ -0.031 Tw T* (\031\030\024\r\027\016 \020\017\n\036\027\026\035\034\027\024\020\024 \022\ \024\035\034\006\026; II)Tj /Span<>> BDC ( )Tj EMC 13.746 0 Td (\227 \007\017\f\021\026\035\034\027\t\005 \022\024\n)Tj 0 Tc 0 Tw (-)Tj 0.014 Tc -0.005 Tw -13.746 -1.218 Td (\023\024\027\036\027\021 \n\036\027\036\036 1 \f\n \r\t\001\036 \017)Tj /Span<>> BDC ( )Tj EMC (\027\036 \002\024\035\036\036 1 \f\n \027\017\032\036 \031\030\024\r)Tj 0 Tc 0 Tw (-)Tj 0.014 Tc 0.233 Tw T* (\027\016 \020\017\n\036\027\026\035\034\027\024\020\024 \022\024\035\034\ \006\026; III)Tj /Span<>> BDC ( )Tj EMC (\227 \007\017\f\021\026\035\034\027\t\005 \022\024\n)Tj 0 Tc 0 Tw (-)Tj 0.014 Tc 0.094 Tw T* [(\023\024\027\036\027\021 \027\017\032\036 1 \f\n \031\030\024\r\027\016 \ \020\017\n\036\027\026\035\034\027\024\020\024 \022\024\035\034\006\026,\ \027\024)14( )]TJ 0.003 Tw T* (\n\036\027\036\036 2)Tj /Span<>> BDC ( )Tj EMC [(\f\n \024\021 T)-52(VL; IV)]TJ /Span<>> BDC ( )Tj EMC [(\227 \023\024\035\027\026\016 \220\r\036\030\f\017\016 \r\035\026\020\026\ \035\017\013\026,)14( )]TJ 0.167 Tw T* (\007\017\f\021\026\035\034\027\t\005 \022\024\n\023\024\027\036\027\021 \ \027\026)Tj /Span<>> BDC ( )Tj EMC (\030\026\f\f\021\024\016\027\017\017)Tj /Span<>> BDC ( )Tj EMC (\234)Tj /Span<>> BDC ( )Tj EMC [(T)-52(VL-2 \f\n.)14( )]TJ 0.048 Tw T* (\025\024\035\017\004\036\f\021\r\036\027\027\026\016 \024\006\036\027\022\ \026 \007\036\235\036\022\021\024\r \023\024)Tj /Span<>> BDC ( )Tj EMC (\004\036\021\022\024 \024\002\024\027\026)Tj 0 Tc 0 Tw (-)Tj 0.014 Tc -0.003 Tw T* (\004\036\027\027\t\n \026\027\026\021\024\n\017\004\036\f\022\017\n \024\ \030\017\036\027\021\017\030\026\n, \r\024\f\023\030\024\017\r\024\007\017\ )Tj 0 Tc 0 Tw (-)Tj 0.014 Tc 0.006 Tw T* (\n\024\f\021\034 \030\036\031\035\034\021\026\021\024\r \017)Tj /Span<>> BDC ( )Tj EMC [(\024\021\f\031\021\f\021\r\017\036 \r\035\017\016\027\017\016 \023\024\035\ \024\032\036\027\017\016)14( )]TJ 0.392 Tw T* [(\023\026\006\017\036\027\021\022\017 \023\024\r\024\035\016\033\021 \f\004\ \017\021\026\021\034 POP-Q \f\021\026\027\007\026\030\021\024\n)14( )]TJ 0.265 Tw T* ([41,42]. \215\024)Tj /Span<>> BDC ( )Tj EMC (\f\017\f\021\036\n\036 POP-Q \023\024\035\024\r\017\027\026 \r\f\036\b \f\ \035\031\004\026)Tj 0 Tc 0 Tw (-)Tj 0.014 Tc 0.154 Tw T* (\036\r \215\230\210 \024\021\027\036\f\036\027\026 \022)Tj /Span<>> BDC ( )Tj EMC (II \f\021\026\007\017\017. \215\030\017)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\n \024\021\f\031\021\f\021\r\031)Tj 0 Tc 0 Tw (-)Tj 0.014 Tc 0.158 Tw T* [(\036\021 )0.6(\022\024\030\030\036\035\016\006\017\016 )0.5(\f\021\026\007\017\017 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 10.937 0 Td [(\r\t\030\026\032\036\027\027\024\f\021\017 )0.5(\f\017\n\023\021\024\n\024\r)14( )]TJ 0 Tw -10.937 -1.218 Td ([35,)Tj /Span<>> BDC ( )Tj EMC (43].)Tj 0 Tc 0.005 Tw T* (\215\217\037 \027\026\004\017\n\024 \f\027\017\032\026\036\021 \022\026\ \004\036\f\021\r\024 \032\017\027\017 \023\026\006\017\036\027\021\024\022\ , \f\024)Tj 0 Tw (-)Tj -0.066 Tw T* (\023\030\024\r\024\032\007\026\016\f\034 \f\017\n\023\021\024\n\026\n\017\ \022\026\022 \224\210\212 \(\022\024\027\f\021\017\023\026\006\017\016,\ \024\013\031)Tj 0 Tw (-)Tj -0.009 Tw T* (\013\036\027\017\036 \027\036\023\024\035\027\024\020\024 \024\023\024\030\ \024\032\027\036\027\017\016 \022\017\001\036\004\027\017\022\026, \007\026\ \r\035\036\027\017\016 )Tj -0.008 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\017\027\024\030\024\007\027\024\020\024 \021\036\035\026, \002\024\035\034\ , \007\017\f\022\024\n\235\024\030\021, \027\036\024\002\b\024\007\017\n\ \024\f\021\034 )Tj 0.342 Tw T* (\023\030\017\n\036\027\036\027\017\016 \023\026\035\034\006\036\r\024\020\ \024 \023\024\f\024\002\017\016 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\007\036\235\036\022\026\006\017\017\), )Tj 0.024 Tw T* (\021\026\022 \017)Tj /Span<>> BDC ( )Tj EMC 2.335 0 Td [(\f\021\030\036\f\f\024\r\024\020\024 \027\036\007\036\030\032\026\027\017\ \016 )0.5(\n\024\004\017 )0.5(\(\224\203\204\), )0.5(\220\030\024\017\016\n\017 )]TJ -0.013 Tw -2.335 -1.218 Td (\017)Tj /Span<>> BDC ( )Tj EMC 0.737 0 Td [(\022\030\024\r\024\021\024\004\017\r\024\f\021\034\033 )0.6(\f\035\017\017\f\021\024\005 )0.6(\024\002\024\035\024\004\022\017 )0.5(\023\030\017)]TJ /Span<>> BDC ( )Tj EMC 17.75 0 Td (\022\024\027\021\026\022\021\036 )Tj 0 Tw -18.487 -1.218 Td (\f)Tj /Span<>> BDC ( )Tj EMC (\024\002\255\036\022\021\026\n\017 \r\027\036\001\027\036\005 \f\030\036\ \007\t [44,45].)Tj 0.004 Tc 0.111 Tw T* (\210\006\036\027\022\031 \f\017\n\023\021\024\n\024\r \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\215\217\037 \023\030\024\r\024\007\016\021 \r\026\035\017\007\017\030\024\ \r\026\027)Tj 0 Tc 0 Tw (-)Tj 0.004 Tc 0.335 Tw T* [(\027\t\n\017 \024\023\030\024\f\027\017\022\026\n\017. PFDI-20 \(P)30(el)30(v)-16(ic Fl)30(o)-16(or Distr)-24(ess)4( )]TJ 0.178 Tw T* [(Invent)17(or)-24(y\) \017\f\023\024\035\034\031\036\021\f\016 \007\035\016 \022\024\035\017\ \004\036\f\021\r\036\027\027\024\005 \024\006\036\027)]TJ 0 Tc 0 Tw (-)Tj 0.004 Tc 0.294 Tw T* (\022\017 \f\017\n\023\021\024\n\024\r, \f\r\016\026\027\027\t\b \f)Tj /Span<>> BDC ( )Tj EMC (\215\230\210. \224\024\f\021\024\017\021 \017)Tj /Span<>> BDC ( )Tj EMC [(\021\030\036\b)4( )]TJ 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0 Tc 0 Tw 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\206)10(\002\036\033 \035\030\032\003\033)30(\n)42(\032)-21(\230\033\241)]TJ 57.136 0 Td (REVIEW)Tj -57.136 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 2)69(4, \023\0224, 202)23(5)]TJ 43.013 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 2)69(4, \023\0224, 202)23(5)]TJ /T1_3 1 Tf 25 0 0 25 20.7776 56.0378 Tm (190)Tj ET endstream endobj 896 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\033\016\017)-10(\026)11(\025\212\016\t\016 \200\022\216\016\215\232\021\215: \215\016\201\016\020\ \016\215\215\220\016 \r\025\222\201\025\b\220 \(\025\235\213\025\201\022\ \t\021\026)11(\016\201\001\026)-20(\200\201\220\))]TJ 41.66 0 Td [(Rectocele in females: unr)31(esolv)12(ed issues \(r)31(e)11(vie)11(w\))]TJ ET 0 0 0 1 K 1 j 1 J [0 2.997]0 d /GS1 gs q 1 0 0 1 46.0167 591.2534 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 43.0197 591.2534 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q [0 2.997]0 d q 1 0 0 1 46.0167 563.6455 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 43.0197 563.6455 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q 0 j 0 J q 1 0 0 1 42.5197 499.9764 cm 0 0 m 453.543 0 l S Q BT 0 0 0 1 k /T1_1 1 Tf 0.007 Tw 9 0 0 9 90.7087 730.4919 Tm (ture indicates that operations on the)Tj /Span<>> BDC ( )Tj EMC [(poster)-36.9(ior w)13(all of)]TJ /Span<>> BDC ( )Tj EMC [(the v)16(agina, reg)12(ardless of)]TJ /Span<>> BDC ( )Tj EMC [(the techniq)14(ue, im)16(p)46.1(rov)13(e the)]TJ /Span<>> BDC ( )Tj EMC (structure )Tj 0.113 Tw 0 -1.111 TD (of)Tj /Span<>> BDC ( )Tj EMC [(the )0.5(poster)-37(ior )0.5(w)13(all with a)]TJ /Span<>> BDC ( )Tj EMC 11.426 0 Td [(high freq)14.1(uency and reduce )0.5(the)]TJ /Span<>> BDC ( )Tj EMC [(freq)14.1(uency of)]TJ /Span<>> BDC ( )Tj EMC 17.858 0 Td [(sym)16(p)13(tomatic manifestations of)]TJ /Span<>> BDC ( )Tj EMC 12.653 0 Td (AR with )Tj 0.035 Tw -41.937 -1.111 Td (a)Tj /Span<>> BDC ( )Tj EMC [(low)12(er freq)14(uency)32(. The)]TJ /Span<>> BDC ( )Tj EMC [(ef)-39.9(fectiv)13(eness of)]TJ /Span<>> BDC ( )Tj EMC [(im)16(plantation of)]TJ /Span<>> BDC ( )Tj EMC [(biological or synthetic g)14(raf)-45.9(ts is no)13(t higher)61(, and the)]TJ /Span<>> BDC ( )Tj EMC (number )Tj 0.036 Tw T* (of)Tj /Span<>> BDC ( )Tj EMC [(po)13(tential com)16(plications, including dyspareunia and erosion of)]TJ /Span<>> BDC ( )Tj EMC [(the synthetic im)16(plant, is higher)51(. S)28.1(tapler transanal )]TJ 0.053 Tw T* [(resection )0.6(of)]TJ /Span<>> BDC ( )Tj EMC 4.904 0 Td [(the )0.5(rectum )0.6(is )0.5(associated )0.6(with )0.5(an)]TJ /Span<>> BDC ( )Tj EMC 13.103 0 Td [(im)16(p)46(rov)13(ement )0.6(in )0.5(the)]TJ /Span<>> BDC ( )Tj EMC 7.921 0 Td [(anatom)11.1(y )0.5(of)]TJ /Span<>> BDC ( )Tj EMC 4.782 0 Td [(the )0.5(PVW )0.6(and )0.5(the)]TJ /Span<>> BDC ( )Tj EMC 6.841 0 Td [(resolution )0.5(of)]TJ /Span<>> BDC ( )Tj EMC 5.301 0 Td (OBMS )Tj 0.121 Tw -42.851 -1.111 Td [(af)-46(ter inter)-41.9(v)12.9(ention. T)53(o)]TJ /Span<>> BDC ( )Tj EMC [(d)26(ate, there are about 300 dif)-40(ferent surgical techniq)14.1(ues for the)]TJ /Span<>> BDC ( )Tj EMC (treatment of)Tj /Span<>> BDC ( )Tj EMC (AR. In 2020, )Tj 0.023 Tw T* (a)Tj /Span<>> BDC ( )Tj EMC [(w)12(orking g)14.1(roup of)]TJ /Span<>> BDC ( )Tj EMC [(the Inter)-14(national F)11(ederation of)]TJ /Span<>> BDC ( )Tj EMC [(Obstetr)-36.9(icians and Gynecologists \(FIGO\), analyzing the)]TJ /Span<>> BDC ( )Tj EMC [(av)16(ailable )]TJ 0.017 Tw T* [(d)26(ata on the)]TJ /Span<>> BDC ( )Tj EMC (treatment of)Tj /Span<>> BDC ( )Tj EMC (AR, concluded that a)Tj /Span<>> BDC ( )Tj EMC [(tactic in)11(v)13(olving traditional \(with im)16(plication of)]TJ /Span<>> BDC ( )Tj EMC [(the rectov)16(aginal fas)]TJ 0 Tw (-)Tj 0.04 Tw T* [(cia\) poster)-36.9(ior colpor)-15.9(raph)12(y with nativ)13(e tissues without the)]TJ /Span<>> BDC ( )Tj EMC (use of)Tj /Span<>> BDC ( )Tj EMC [(synthetic im)16(plants is p)46(referable. How)12(ev)13(er)61(, there is )]TJ -0.025 Tw T* [(no)13(t enough d)26.1(ata to)]TJ /Span<>> BDC ( )Tj EMC [(deter)-13.9(mine the)]TJ /Span<>> BDC ( )Tj EMC (reference method of)Tj /Span<>> BDC ( )Tj EMC (surgical treatment of)Tj /Span<>> BDC ( )Tj EMC (AR, and the)Tj /Span<>> BDC ( )Tj EMC [(issue req)14(uires fur)-39.9(ther study)32(.)]TJ /T1_2 1 Tf 0.01 Tc -0.01 Tw 8 0 0 8 42.5596 625.2226 Tm [(KEYW)22(ORDS:)]TJ /T1_1 1 Tf 0 Tc 0.118 Tw 4.948 0 Td [( rectocele, pelvic org)12.1(an p)45.9(rolapse, w)12(omen of)]TJ /Span<>> BDC ( )Tj EMC [(rep)46(roductiv)13(e ag)12(e, laparoscopic sacrocolpoper)-36.9(ineope)-14.9(xy)42(, poster)-37(ior colpor)-16(raph)12.1(y)42(, lev)16(atoro)]TJ 0 Tw (-)Tj 0.023 Tw -4.953 -1.2 Td [(plasty)42(, rectal resection)]TJ /T1_2 1 Tf 0.01 Tc 0.018 Tw 0.005 -1.909 Td [(C)19(ONFL)-33(ICT)5( OF)]TJ /Span<>> BDC 5.312 0 Td ( )Tj EMC [(INTE)25(REST)61.9(:)]TJ /T1_1 1 Tf 0 Tc 0.023 Tw 4.559 0 Td ( the)Tj /Span<>> BDC ( )Tj EMC [(authors declare that there is no conf)-22(lict of)]TJ /Span<>> BDC ( )Tj EMC (interest)Tj /T1_2 1 Tf 0.036 Tc -0.044 Tw -9.871 -2.617 Td [(F)3.6(O)-4.1(R)9.1( C)-17(I)-15.2(T)45.9(A)37.9(T)-24(I)-0.9(O)0.5(N)0.6(:)]TJ /T1_3 1 Tf 0.022 Tc -0.035 Tw 6.382 0 Td [( M)-12.2(e)-21.8(t)-30.4(r)-55.9(i)-2.8(n)-10.7(s)-10.7(k)-45.2(y Y)51.8(.)52(Y)13.1(u)-8.6(.)-23(, B)-18.6(e)-17.6(l)-20.4(o)-12.9(u)-21.4(s)-18.7(o)-9.8(v)]TJ /Span<>> BDC ( )Tj EMC [(A)-22.5(.)-6.9(M)-6.6(.)-23.1(, S)-1(i)-7.8(z)-10.8(o)-8.7(n)-15.7(e)-11(n)-8.4(k)-3.3(o)]TJ /Span<>> BDC ( )Tj EMC [(N)-2.3(.)-23.5(A)-22.6(.)-23(, K)-10.7(o)-11.4(r)-42.4(z)-12.2(h)-6.5(u)-9.2(k)]TJ /Span<>> BDC ( )Tj EMC [(M)-6.7(.)-26.4(S)-9.2(.)-23(, M)-5.2(u)-8(l)-23.2(e)-11.1(n)-14(d)-14.9(e)-24.7(e)-15.4(v)]TJ /Span<>> BDC ( )Tj EMC [(S)-9.2(.)41(V)40.2(. R)-6.2(e)-18.7(c)-41(t)-21.5(o)-16.3(c)-9.3(e)-17.5(l)-23.3(e i)-2.8(n f)-28.1(e)-11(m)-7.9(a)-11(l)-23.2(e)-22.4(s)-7.5(: u)-4.6(n)-7.2(r)-18.6(e)-22.3(s)-18.7(o)-15.1(l)-5.2(v)-18.3(e)-20.5(d i)-6.9(s)-21.9(s)-8.3(u)-12.1(e)-22.3(s)22( )]TJ -0.016 Tc 0.016 Tw -6.387 -1.2 Td [(\(r)-58.1(e)-54.8(v)-90.8(i)-50(e)-51.5(w)-19.4(\))-28.6(.)-39.3( )]TJ /T1_1 1 Tf 0.033 Tc -0.033 Tw 4.166 0 Td [(K)13.9(ol)3.6(op)2.4(r)3.1(o)3.4(k)-19.2(t)2.2(ol)3.6(o)-3.3(g)-13.2(i)6.7(a)5.8(.)]TJ /T1_3 1 Tf 0.023 Tc 0.024 Tw 7.019 0 Td [( 2)-8.9(0)-3.8(2)-1.4(5)23.3(;)9.8(2)8.8(4)-13.5(\()40.1(4)30.3(\))14.5(:)20.9(1)-2.4(8)-31.8(8)-24.2(\226)11.7(2)-8.9(0)-23.4(0)6.5(. \()-0.9(i)-3.2(n R)-6.5(u)-21.9(s)-22.3(s)-15.5(.)43.2(\))10.4(. h)-17.2(t)-49.4(t)-29.4(p)-18.7(s)-8(:)1.9(/)84.7(/)36.4(d)-11.1(o)-12.5(i.)2.7(o)-11.8(r)-16.7(g)-22.8(/)11.2(1)14(0)6.5(.)-5.6(3)7.9(3)-15.9(8)1.3(7)4.6(8/)7.9(2)-8.9(0)9.3(7)-1.9(3)-13.3(-)41.2(7)10.7(55)-8.9(6)-26.7(-)9.7(2)-8.9(0)-3.8(2)-1.4(5)-23.6(-)9.7(2)8.9(4)-28.5(-)-30.3(4)-28.6(-)55.2(1)-2.5(8)-31.7(8)-25.8(-)9.8(2)-8.9(0)-23.5(0)]TJ /T1_2 1 Tf 0.01 Tc 0.134 Tw -11.18 -2.617 Td [(\021\024\027\030\026)5( )0.5(\024\033\023)5( \t\030\027\030\t\032\026\037\032:)]TJ /T1_1 1 Tf 0 Tc 0.139 Tw 10.808 0 Td [( )0.5(\207\022\031\034\020\016\020\021\034 )0.5(\217\022\021\034\027\037\004 )0.5(\205\027\016\021\024\037\020\b\033\034\036\022\005, )0.5(\216\223\210\240\215 )0.5(\240 )0.5(\253\034\016\020\020\034-\006\016\b\022\007\022\020\024\021\037\030 )0.6(\037\021\037\b\016\006\022\030 )0.6(\022\006\016\020\022 \207.\214.)]TJ /Span<>> BDC ( )Tj EMC 39.137 0 Td [(\r\022\033\034\036\037\273 )0.5(\214\240 )0.5(\213\216, )]TJ 0.182 Tw -49.95 -1.2 Td (\021\037\017\016\b\033\037 \036\034\016\020\020\034-\006\034\033\024\021\ \034\004 \002\022\033\023\033\013\022\022, \023\027.)Tj /Span<>> BDC ( )Tj EMC (\205\021\037\b\016\006\022\021\037 \231\016\025\016\b\016\036\037, \b.)Tj /Span<>> BDC ( )Tj EMC (6\201, \207\037\020\021\035-\t\016\035\016\033\025\023\033\013, 194044, \ \213\034\024\024\022\030; \035\016\027. 8)Tj /Span<>> BDC ( )Tj EMC (\(911\)7473075; e-mail: )Tj 0 Tw 0 -1.2 TD (n_sizonenko@mail.ru)Tj /T1_2 1 Tf 0.01 Tc -0.03 Tw 0.005 -1.2 Td [(ADDRESS)5( F)13(OR)5( C)19(ORRESPONDEN)23(CE:)]TJ /T1_1 1 Tf 0 Tc -0.025 Tw 13.954 0 Td [( Nik)13(olay A. Sizonenk)13(o, S.M.)]TJ /Span<>> BDC ( )Tj EMC [(Kirov Militar)-43(y Medical Academ)11(y)42(, Depar)-40(tment of)]TJ /Span<>> BDC ( )Tj EMC [(N)18(av)16(al Surg)12(er)-43(y)42(, Ak)11(ademik)11.1(a Lebedev)16.1(a )]TJ 0.023 Tw -13.959 -1.2 Td [(st., 6g, Saint P)15(etersburg, 194044, R)22(ussia; tel. 8)]TJ /Span<>> BDC ( )Tj EMC [(\(911\)7473075; e-mail: n_sizonenk)13(o@mail.ru)]TJ 0 Tw 0 -2.792 TD (\n\037\035\037 \f\034\024\035\023\f\027\016\020\022\030)Tj /Span<>> BDC ( )Tj EMC (\227 26.05.2025)Tj /Span<>> BDC ( )Tj EMC 19.488 0 Td (\t\034\024\027\016 \b\034\033\037\025\034\035\021\022)Tj /Span<>> BDC ( )Tj EMC (\227 28.08.2025)Tj /Span<>> BDC ( )Tj EMC 18.78 0 Td (\t\033\022\020\030\035\034 \021)Tj /Span<>> BDC ( )Tj EMC (\f\023\025\027\022\021\037\007\022\022)Tj /Span<>> BDC ( )Tj EMC (\227 10.11.2025)Tj ( )Tj -38.268 -1.375 Td (Received)Tj /Span<>> BDC ( )Tj EMC (\227 26.05.2025)Tj /Span<>> BDC ( )Tj EMC 19.488 0 Td (Revised)Tj /Span<>> BDC ( )Tj EMC (\227 28.08.2025)Tj /Span<>> BDC ( )Tj EMC 18.78 0 Td (Accepted for publication)Tj /Span<>> BDC ( )Tj EMC (\227 10.11.2025)Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 42.5896 444.7359 Tm (\023\023\034\226\034\022\031\034)Tj 0 0 0 1 k /GS1 gs /T1_3 1 Tf 0 Tc 0.083 Tw 10 0 0 10 42.5197 420.3799 Tm (\200)Tj /Span<>> BDC ( )Tj EMC (\030\016\007\031 \023\024\030\026\032\036\027\017\005 \023\030\024\n\036\ \032\027\024\f\021\017 \031)Tj /Span<>> BDC ( )Tj EMC (\032\036\027\013\017\027 \026\n\036\021\027\024\036 )Tj 0.368 Tw 0 -1.218 TD (\n\036\f\021\024 \026\027\017\n\026\036\021 \023\030\024\035\026\023\f \ \021\026\024\r\t\b \024\030\020\026\027\024\r. \210\007\027\017\n )Tj 0.155 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\036\020\024 \r\026\030\017\026\027\021\024\r \016\r\035\016\036\021\f\016\ \030\036\022\021\024\006\036\035\036)Tj /Span<>> BDC ( )Tj EMC (\227 \r\t\023\016\004\017\r\026)Tj 0 Tw (-)Tj 0.161 Tw T* (\027\017\036 \f\021\036\027\022\017 \023\030\016\n\024\005 \022\017\001\022\ \017 \r\n\036\f\021\036 \f)Tj /Span<>> BDC ( )Tj EMC (\026\007\027\036\005 \f\021\036\027\022\024\005 )Tj -0.005 Tw T* (\r\035\026\020\026\035\017\013\026 \(\003\224\200\) \r)Tj /Span<>> BDC ( )Tj EMC (\f\021\024\030\024\027\031 \r\035\026\020\026\035\017\013\026 \(\023\036\ \030\036\007\027\036\036 \030\036\022)Tj 0 Tw (-)Tj 0.02 Tw T* (\021\024\006\036\035\036\) \017/\017\035\017 \023\024)Tj /Span<>> BDC ( )Tj EMC (\026\007\027\036\005 \023\024\035\031\024\022\030\031\032\027\024\f\021\ \017 \022\017\001\022\017 \(\026)Tj 0 Tw (-)Tj 0.114 Tw T* (\007\027\036\036 \030\036\022\021\024\006\036\035\036\) [1]. \215\036\030\ \036\007\027\036\036 \030\036\022\021\024\006\036\035\036 \(\215\217\037\ \) \f\024)Tj 0 Tw (-)Tj 0.088 Tw T* [(\023\030\024\r\024\032\007\026\036\021\f\016 )0.6(\f\017\027\007\030\024\n\024\n )0.5(\024\002\f\021\030\031\022\021\017\r\027\024\005 )0.6(\007\036\235\036\022\026\006\017\017 )]TJ 0.172 Tw T* (\(\224\210\212\) \f)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\017\n\017 \f\017\n\023\021\024\n\026\n\017, \022\026\022 \002\ \024\035\034, \022\024\027\f\021\017\023\026\006\017\016 )Tj 0.006 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\027\036\024\002\b\024\007\017\n\024\f\021\034 \017\f\023\024\035\034\024\ \r\026\027\017\016 \023\026\035\034\006\036\r\024\020\024 \023\024\f\024\ \002\017\016 )Tj 0.316 Tw T* (\023\030\017)Tj /Span<>> BDC ( )Tj EMC (\007\036\235\036\022\026\006\017\017 [2]. \217\026\f\023\030\024\f\021\030\ \026\027\036\027\027\024\f\021\034 \023\030\024\035\026\023\f\026 )Tj 0.195 Tw T* [(\021\026\024\r\t\b )0.5(\024\030\020\026\027\024\r \(\215\230\210\) )0.5(\f\030\036\007\017 \032\036\027\013\017\027 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC (\024\021\007\036\035\034\027\t\b )Tj 0.032 Tw T* (\f\021\030\026\027\026\b \007\024\f\021\017\020\026\036\021 50% [3]. \200\ )Tj /Span<>> BDC ( )Tj EMC (\217\024\f\f\017\017 \220\021\024\021 \023\024\022\026\026\021\036\035\034\ )Tj 0.098 Tw T* (\023\030\036\r\t\001\026\036\021 30% [4,5]. \215\030\017)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\n \017\024\035\017\030\024\r\026\027\027\024\036 \215\217\037\ )Tj 0 Tw T* (\027\026\002\035\033\007\026\036\021\f\016 \r)Tj /Span<>> BDC ( )Tj EMC (25% \f\035\031\004\026\036\r [4].)Tj 0.198 Tw T* (\232\026\f\021\024\021\026 \215\230\210 \031\r\036\035\017\004\017\r\026\ \036\021\f\016 \027\026)Tj /Span<>> BDC ( )Tj EMC (40% \022\026\032\007\t\036 10 \035\036\021 )Tj 0.022 Tw T* (\032\017\027\017 [6]. \200)Tj /Span<>> BDC ( )Tj EMC (\r\024\030\026\f\021\036 \007\024)Tj /Span<>> BDC ( )Tj EMC (30 \035\036\021 \023\030\017\027\026\022\017 \215\230\210 \r\f\021\030\036\ )Tj 0 Tw (-)Tj 0.133 Tw T* (\004\026\033\021\f\016 \r)Tj /Span<>> BDC ( )Tj EMC (10% \f\035\031\004\026\036\r. \200)Tj /Span<>> BDC ( )Tj EMC (\007\017\026\023\026\024\027\036 30\22645)Tj /Span<>> BDC ( )Tj EMC (\035\036\021 \030\026\f)Tj 0 Tw (-)Tj 0.218 Tw T* (\023\030\024\f\021\030\026\027\036\027\027\024\f\021\034 \f\024\f\021\026\ \r\035\016\036\021 \024\022\024\035\024 40%. \211)Tj /Span<>> BDC ( )Tj EMC (\032\036\027\013\017\027 )Tj 0.068 Tw T* [(\f\021\026\030\001\036 )0.5(50)]TJ /Span<>> BDC ( )Tj EMC [(\035\036\021 )0.5(\215\230\210 \r\f\021\030\036\004\026\036\021\f\016 )0.5(\031)]TJ /Span<>> BDC ( )Tj EMC [(50%. )0.5(\025\026\032\007\026\016 )0.5(\023\016\021\026\016 )]TJ T* (\032\036\027\013\017\027\026 \f)Tj /Span<>> BDC ( )Tj EMC (\215\230\210 \r\027\036 \026\r\017\f\017\n\024\f\021\017 \024\021 \r\024\ \030\026\f\021\026 \027\031\032\007\026)Tj 0 Tw (-)Tj -0.017 Tw T* (\036\021\f\016 \r)Tj /Span<>> BDC ( )Tj EMC (\024\023\036\030\026\021\017\r\027\024\n \035\036\004\036\027\017\017 [5\ ]. \217\026\f\023\030\024\f\021\030\026\027\036\027\027\024\f\021\034 )Tj 0.205 Tw T* (\215\230\210 \f\030\036\007\017 \032\036\027\013\017\027 \036\r\030\024\023\ \036\024\017\007\027\024\020\024 \017)Tj /Span<>> BDC ( )Tj EMC (\035\026\021\017\027\024\026\n\036\030\017)Tj 0 Tw (-)Tj 0.278 Tw T* [(\022\026\027\f\022\024\020\024 \023\030\024\017\f\b\024\032\007\036\027\017\ \016 )0.5(\r\t\001\036. \210\023\036\030\026\021\017\r\027\t\036 )0.5(\r\n\036)]TJ 0 Tw (-)Tj 0.162 Tw T* [(\001\026\021\036\035\034\f\021\r\026 )0.6(\023\024)]TJ /Span<>> BDC ( )Tj EMC 6.439 0 Td [(\023\024\r\024\007\031 )0.5(\215\230\210 )0.6(\f\030\036\007\017 )0.5(\023\030\036\007\f\021\026\r\017\021\036\035\034\027\017\006 )]TJ 0.317 Tw -6.439 -1.218 Td (\027\036\020\030\024\017\007\027\024\005 \030\026\f\t \023\030\024\r\024\ \007\016\021\f\016 \r)Tj /Span<>> BDC ( )Tj EMC (3 \030\026\026 \030\036\032\036, \004\036\n )Tj -0.005 Tw T* (\031)Tj /Span<>> BDC ( )Tj EMC 0.672 0 Td [(\036\r\030\024\023\036\024\017\007\027\t\b )0.6(\032\036\027\013\017\027 )0.5([7,8]. )0.5(\236\031\004\036\027\017\036 )0.6(\030\026\f\023\030\024\f\021\030\026)]TJ 0 Tw (-)Tj 0.195 Tw -0.672 -1.218 Td [(\027\036\027\027\024\f\021\017 )0.5(\215\230\210 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC [(\006\036\035\024\n, )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC [(\215\217\037 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 14.338 0 Td [(\004\026\f\021\027\024\f\021\017, )0.5(\026\021\030\031\007)]TJ 0 Tw (-)Tj 0.218 Tw -14.338 -1.218 Td (\027\036\027\024 \002\036\f\f\017\n\023\021\024\n\027\t\n \021\036\004\036\ \027\017\036\n \027\026)Tj /Span<>> BDC ( )Tj EMC (\030\026\027\027\017\b \f\021\026\007\017\016\b. )Tj 0.173 Tw 23.244 36.534 Td (\204\026\027\017\235\036\f\021\026\006\017\016 \215\217\037 \023\030\024\ \017\f\b\024\007\017\021 \004\036\030\036 10\22615)Tj /Span<>> BDC ( )Tj EMC (\035\036\021 \024\021 )Tj 0.084 Tw T* [(\027\026\004\026\035\026 )0.6(\030\026\r\017\021\017\016 )0.6(\215\230\210 )0.5([9]. )0.5(\224\024\020\035\026\f\027\024 )0.5(\024\023\031\002\035\017\022\024\r\026\027\027\t\n )]TJ 0.051 Tw T* (\007\026\027\027\t\n, \007\024)Tj /Span<>> BDC ( )Tj EMC (90% \023\036\030\r\017\004\027\t\b \f\035\031\004\026\036\r \215\230\210\ \r\t\016\r\035\016\033\021\f\016 )Tj T* (\023\030\017)Tj /Span<>> BDC ( )Tj EMC (\r\030\026\004\036\002\027\024\n \024\f\n\024\021\030\036, \026)Tj /Span<>> BDC ( )Tj EMC (\027\036 \027\026)Tj /Span<>> BDC ( )Tj EMC (\024\f\027\024\r\026\027\017\017 \023\030\036\007\255\016\r)Tj 0 Tw (-)Tj 0.019 Tw T* [(\035\016\036\n\t\b )0.6(\032\026\035\024\002 )0.5([10,11,12], )0.5(\004\021\024 )0.5(\023\024\007\004\036\030\022\017\r\026\036\021 )0.6(\r\026\032\027\024\f\021\034 )]TJ 0.164 Tw T* (\f\022\030\017\027\017\027\020\024\r\t\b \n\036\030\024\023\030\017\016\021\ \017\005. \215\024\n\017\n\024 \220\021\024\020\024, \023\024\023\026\007\ \026)Tj 0 Tw (-)Tj 0.066 Tw T* (\027\017\036 \215\217\037 \r)Tj /Span<>> BDC ( )Tj EMC (\023\024\035\036 \030\036\027\017\016 \022\026\022 \020\017\027\036\022\ \024\035\024\020\017\017, \021\026\022 \017)Tj /Span<>> BDC ( )Tj EMC (\022\024\035\024)Tj 0 Tw (-)Tj 0.076 Tw T* (\030\036\022\021\026\035\034\027\024\005 \b\017\030\031\030\020\017\017 \ \017)Tj /Span<>> BDC ( )Tj EMC (\031\030\024\035\024\020\017\017 \016\r\035\016\036\021\f\016 \023\030\017\ \004\017\027\024\005 )Tj -0.074 Tw T* (\030\026\027\t\b \023\024\007\b\024\007\024\r \022)Tj /Span<>> BDC ( )Tj EMC [(\007\017\026\020\027\024\f\021\017\022\036 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC [(\035\036\004\036\027\017\033 )0.5(\023\026\006\017\036\027\021\024\022. )]TJ 0.032 Tw T* (\230\026\022, \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\024\023\030\024\f\036 \r\030\026\004\036\005 \r)Tj /Span<>> BDC ( )Tj EMC (\207\036\035\034\020\017\017 \021\024\035\034\022\024 41% \b\017\030\031\ \030)Tj 0 Tw (-)Tj -0.024 Tw T* (\020\024\r \024\023\030\036\007\036\035\017\035\017 \215\217\037 \022\026\ \022 \253\023\030\024\035\026\023\f \026\007\027\036\005 \f\021\036\027\ \022\017 \r\035\026)Tj 0 Tw (-)Tj -0.039 Tw T* (\020\026\035\017\013\026\273. \214\017\001\034 \023\024\035\024\r\017\027\ \026 \b\017\030\031\030\020\024\r \017\f\023\024\035\034\024\r\026\035\017\ \r\035\026)Tj 0 Tw (-)Tj T* (\020\026\035\017\013\027\024\036 \036\030\022\026\035\024, \017)Tj /Span<>> BDC ( )Tj EMC (\021\030\036\021\034 \024\006\036\027\017\r\026\035\017 \215\230\210 \023\ \024)Tj /Span<>> BDC ( )Tj EMC (\f\017\f\021\036\n\036 )Tj -0.026 Tw T* (POP-Q. \203\036 \002\024\035\036\036 60% \020\017\027\036\022\024\035\024\ \020\024\r \023\030\024\r\024\007\017\035\017 \023\026\035\034\006\036)Tj 0 Tw (-)Tj -0.032 Tw T* [(\r\024\036 \030\036\022\021\026\035\034\027\024\036 \017\f\f\035\036\007\ \024\r\026\027\017\036. )0.5(\230\030\026\027\f\r\026\020\017\027\026\035\034\027\024\036 \211\003\236\ )]TJ 0.128 Tw T* (\023\030\024\r\024\007\017\035\024\f\034 \021\024\035\034\022\024 \020\017\ \027\036\022\024\035\024\020\026\n\017, \021\024\020\007\026 \022\026\022\ \026\027\026\035\034)Tj 0 Tw (-)Tj 0.067 Tw T* (\027\031\033 \n\026\027\024\n\036\021\030\017\033 \017\f\023\024\035\034\ \024\r\026\035\017 65% \b\017\030\031\030\020\024\r \017)Tj /Span<>> BDC ( )Tj EMC (14% )Tj 0 Tw T* (\020\017\027\036\022\024\035\024\020\024\r.)Tj 0.59 Tw T* (\025\024\035\024\030\036\022\021\026\035\034\027\t\036 \b\017\030\031\030\ \020\017, \031\030\024\035\024\020\017 \017)Tj /Span<>> BDC ( )Tj EMC (\020\017\027\036\022\024\035\024\020\017 )Tj 0.421 Tw T* (\007\036\005\f\021\r\031\033\021 \022\026\032\007\t\036 \027\026)Tj /Span<>> BDC ( )Tj EMC (\024\f\027\024\r\036 \f\r\024\017\b \023\030\024\235\017\035\034\027\t\b\ )Tj 0.087 Tw T* (\023\024\007\020\024\021\024\r\022\017 \017)Tj /Span<>> BDC ( )Tj EMC (\024\023\t\021\026, \r\t\002\017\030\026\016 \r)Tj /Span<>> BDC ( )Tj EMC (\022\026\004\036\f\021\r\036 \023\030\036\007\023\024\004\021\017)Tj 0 Tw (-)Tj 0.208 Tw T* (\021\036\035\034\027\024\020\024 \024\023\036\030\026\021\017\r\027\024\020\ \024 \007\024\f\021\031\023\026 \021\030\026\027\f\026\027\026\035\034\027\ \t\005, \026\002)Tj 0 Tw (-)Tj -0.009 Tw T* (\007\024\n\017\027\026\035\034\027\t\005 \017\035\017 \021\030\026\027\f\ \r\026\020\017\027\026\035\034\027\t\005 [11]. \200\024\n\024\032\027\024\ , )Tj 0.093 Tw T* (\027\036\022\024\021\024\030\026\016 \030\026\027\017\006\026 \r)Tj /Span<>> BDC ( )Tj EMC (\023\030\036\024\002\035\026\007\026\033\013\017\b \023\030\024\002\035\036\ \n\026\b \026)Tj 0 Tw (-)Tj 0.063 Tw T* (\f\021\026\r\035\016\036\021 \023\026\006\017\036\027\021\024\022 \017\002\ \017\030\026\021\034 \007\035\016 \024\002\030\026\013\036\027\017\016 \030\ \026\027\t\b )Tj 0 Tw T* (\f\023\036\006\017\026\035\017\f\021\024\r.)Tj 0.131 Tw T* (\240\036\027\013\017\027\t \030\036\023\030\024\007\031\022\021\017\r\027\ \024\020\024 \r\024\030\026\f\021\026 \(\217\200\) \r)Tj /Span<>> BDC ( )Tj EMC (\022\024\027\021\036\022)Tj 0 Tw (-)Tj 0.312 Tw T* (\f\021\036 \215\230\210 \017)Tj /Span<>> BDC ( )Tj EMC (\215\217\037 \023\030\036\007\f\021\026\r\035\016\033\021 \024\021\007\036\ \035\034\027\t\005 \017\027\021\036\030\036\f. )Tj 0.3 Tw T* (\003\026\002\024\035\036\r\026\027\017\036 \r)Tj /Span<>> BDC ( )Tj EMC (\007\026\027\027\024\005 \020\030\031\023\023\036 \007\035\017\021\036\035\ \034\027\024 \023\030\024\021\036\022\026)Tj 0 Tw (-)Tj 0.272 Tw T* [(\036\021 \002\036\f\f\017\n\023\021\024\n\027\024. \230\026\022, )0.5(\212\026\027\017\035\017\027\026 \210.\202., )0.5(\200\024\035\022\024\r)]TJ /Span<>> BDC ( )Tj EMC 20.537 0 Td (\200.\206. )Tj 1.065 Tw -20.537 -1.218 Td (\023\030\036\007\f\021\026\r\017\035\017 \017\f\f\035\036\007\024\r\026\027\ \017\036 \030\026\f\023\030\024\f\021\030\026\027\036\027\027\024\f\021\017\ )Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 0 Tw 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\206)10(\002\036\033 \035\030\032\003\033)30(\n)42(\032)-21(\230\033\241)]TJ 57.136 0 Td (REVIEW)Tj /T1_5 1 Tf 25 0 0 25 505.527 56.0378 Tm (189)Tj ET endstream endobj 892 0 obj [898 0 R] endobj 893 0 obj <>stream q /GS0 gs /Fm0 Do Q 0 0 0 1 K 1 j 1 J [0 2.997]0 d /GS1 gs q 1 0 0 1 74.3631 312.4104 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 71.3661 312.4104 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q [0 2.997]0 d q 1 0 0 1 74.3631 284.8025 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 71.3661 284.8025 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q BT 0 0 0 1 k /T1_0 1 Tf 10 0 0 10 70.8661 724.8299 Tm (https://doi.org/10.33878/2073-7556-2025-24-4-188-200)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0.023 Tw 19 0 0 19 126.2016 695.3259 Tm [(\033\016\017)-10(\026)11(\025\212\016\t\016 \200\022)-23.3(\216\016\215\232\021\215: \215\016\201\016\020\016\215\215\220\016 \r\025\ \222\201\025\b\220 )]TJ 0 Tw 4.869 -1.105 Td [(\(\025\235\213\025\201\022)-23.3(\t\021\026)11(\016\201\001\026)-20(\200\201\220\))]TJ 0 0 0 1 k /GS1 gs 14 0 0 14 70.8661 649.822 Tm [(\007\016\026\201\021\215\b\017\021\207\022)-23.2(\027.\204.)]TJ 8.162 0 0 8.162 174.525 654.484 Tm (1)Tj 0.023 Tw 14 0 0 14 179.161 649.822 Tm [(, \206\016\t\025\200\b\025\r\022)-23.2(\n)-31(.\007.)]TJ 0 Tw 8.162 0 0 8.162 273.7656 654.484 Tm (1)Tj 0.023 Tw 14 0 0 14 278.4016 649.822 Tm [(, \013\021\213\025\215\016\215\017)10.1(\025\022)-23.3(\217.\n)-31(.)]TJ 0 Tw 8.162 0 0 8.162 379.2782 654.484 Tm (2)Tj 0.023 Tw 14 0 0 14 383.9142 649.822 Tm [(, \037)31(\025\201\216\200\017\022)-23.2(\007.\013.)]TJ 0 Tw 8.162 0 0 8.162 467.5156 654.484 Tm (2)Tj 14 0 0 14 472.1515 649.822 Tm (, )Tj -28.663 -1.143 Td [(\007\200\t\016\215\211\016\016\r\022)-23.2(\013.\006.)]TJ 8.162 0 0 8.162 162.9607 638.484 Tm (2)Tj 5.83 0 0 5.83 70.8661 619.4827 Tm (1)Tj 0.023 Tw 10 0 0 10 74.1775 616.1527 Tm [(\037\t\021\215\021\017\001 \r\220\b\025\017\021 \024\016\211\021\212\021\ \215\b\017\021 \026)11(\016)21(\215\025\t\025\202\021\207 \021\024\016\215\021 \217.\030.\022)-23.2(\034\021\201\025\202)10(\025\r\001 \203\031\206)21.1(\036)20(\230 \006\036 \253\013\001\215\017)-9.9(\026)-42(-\034\016\026)11(\016\201\235\200\201\202)10(\b\017\021\207 )]TJ -0.331 -1.2 Td [(\202)10(\025\b\200\211\001\201\b)-10(\026\r\016\215\215\220\207 \200\215\021\r\016\201\b\021\026)11.1(\016\026\273 \(\215\001\235. \201\016\017\021 \203\025\215\026)11(\001\215\017\021, \211.\022)-23.3(1)113(5)23(4, \202)62(.\022)-23.3(\013\001\215\017)-9.9(\026)-42(-\034\016\026)11(\016\201\235\200\201\202)41(, 1)138(90020, \033\025\b\b\021\004\))]TJ 0 Tw ( )Tj 5.83 0 0 5.83 70.8661 595.4827 Tm (2)Tj 0.023 Tw 10 0 0 10 74.1775 592.1527 Tm [(\203\031\206\006\036)20(\230 \006\036 \253\006\025\016\215\215\025-\024\016\211\021\212\021\215\b\ \017\001\004 \001\017\001\211\016\024\021\004 \021\024\016\215\021 \013.\ \007.\022)-23.2(\037)19.9(\021\201\025\r\001\273 \007\036 \033\203 \(\200\t.\022)-23.3(\n\017\001\211\016\024\021\017\001 \035\016\235\016\211\016\r\001, )]TJ -0.331 -1.2 Td [(\211.\022)-23.3(6\216, \202)61.9(.\022)-23.3(\013\001\215\017)-10(\026)-42(-\034\016\026)11.1(\016\201\235\200\201\202)41(, 1)138(9)80(40)25(44, \033\025\b\b\021\004\))]TJ /T1_0 1 Tf 0.205 Tw 9 0 0 9 119.0551 561.6488 Tm [(\207\033\016\b\022 )0.5(\f\034\033\037\201\016\020\022\004 )0.5(\f\033\034\006\016\201\020\034\024\035\022 )0.5(\023)]TJ /Span<>> BDC ( )Tj EMC 14.795 0 Td [(\201\016\020\235\022\020 )0.5(\031\037\006\016\035\020\034\016 )0.5(\006\016\024\035\034 )0.5(\031\037\020\022\006\037\016\035 )0.5(\f\033\034\027\037\f\024 )0.5(\035\037\031\034\036\032\002 )0.5(\034\033\013\037\020\034\036. \240\b\020\022\006 )]TJ 0.155 Tw -14.795 -1.111 Td (\022\031)Tj /Span<>> BDC ( )Tj EMC (\016\013\034 \036\037\033\022\037\020\035\034\036 \030\036\027\030\016\035\ \024\030 \033\016\021\035\034\007\016\027\016)Tj /Span<>> BDC ( )Tj EMC (\227 \036\032\f\030\005\022\036\037\020\022\016 \024\035\016\020\021\022\ \f\033\030\006\034\004 \021\022\001\021\022 \036\006\016\024\035\016 \024\ )Tj /Span<>> BDC ( )Tj EMC (\031\037\b\020\016\004 \024\035\016\020\021\034\004 )Tj 0.211 Tw 0 -1.111 TD (\036\027\037\013\037\027\022\235\037 \(\255\207\) \036)Tj /Span<>> BDC ( )Tj EMC (\024\035\034\033\034\020\023 \036\027\037\013\037\027\022\235\037 \(\f\016\ \033\016\b\020\016\016 \033\016\021\035\034\007\016\027\016\) \022/\022\027\ \022 \f\034)Tj /Span<>> BDC ( )Tj EMC (\031\037\b\020\016\004 \f\034\027\023\034\021\033\023\201\020\034\024\035\ \022 \021\022\001\021\022 )Tj 0.186 Tw T* (\(\031\037\b\020\016\016 \033\016\021\035\034\007\016\027\016\). \t\016\033\ \016\b\020\016\016 \033\016\021\035\034\007\016\027\016 \(\t\213\221\) \024\ \034\f\033\034\036\034\201\b\037\016\035\024\030 \024\022\020\b\033\034\006\ \034\006 \034\025\024\035\033\023\021\035\022\036\020\034\004 \b\016\017\ \016\021\037\007\022\022 )Tj 0.091 Tw T* (\(\207\240\n\) \024)Tj /Span<>> BDC ( )Tj EMC (\035\037\021\022\006\022 \024\022\006\f\035\034\006\037\006\022, \021\037\ \021 \025\034\027\003, \021\034\020\024\035\022\f\037\007\022\030 \022)Tj /Span<>> BDC ( )Tj EMC (\020\016\034\025\002\034\b\022\006\034\024\035\003 \022\024\f\034\027\003\ \031\034\036\037\020\022\030 \f\037\027\003\007\016\036\034\013\034 \f\034\ \024\034\025\022\030 )Tj 0.007 Tw T* (\f\033\022)Tj /Span<>> BDC ( )Tj EMC (\b\016\017\016\021\037\007\022\022. \213\037\024\f\033\034\024\035\033\037\ \020\016\020\020\034\024\035\003 \f\033\034\027\037\f\024\037 \035\037\031\ \034\036\032\002 \034\033\013\037\020\034\036 \(\t\202\240\) \024\033\016\ \b\022 \201\016\020\235\022\020 \036)Tj /Span<>> BDC ( )Tj EMC (\034\035\b\016\027\003\020\032\002 \024\035\033\037\020\037\002 )Tj 0.093 Tw T* (\b\034\024\035\022\013\037\016\035 50%. )Tj /Span<>> BDC ( )Tj EMC (\213\034\024\024\022\022 \220\035\034\035 \f\034\021\037\031\037\035\016\ \027\003 \f\033\016\036\032\001\037\016\035 30%. \236\016\020\235\022\020\ \032 \033\016\f\033\034\b\023\021\035\022\036\020\034\013\034 \036\034\031\ \033\037\024\035\037 \(\213\) )Tj 0.058 Tw T* (\036)Tj /Span<>> BDC ( )Tj EMC (\021\034\020\035\016\021\024\035\016 \t\202\240 \022)Tj /Span<>> BDC ( )Tj EMC (\t\213\221 \f\033\016\b\024\035\037\036\027\030\026\035 \034\035\b\016\027\ \003\020\032\004 \022\020\035\016\033\016\024. \255\037\025\034\027\016\036\ \037\020\022\016 \036)Tj /Span<>> BDC ( )Tj EMC (\b\037\020\020\034\004 \013\033\023\f\f\016 \b\027\022\035\016\027\003\020\ \034 \f\033\034)Tj 0 Tw (-)Tj 0.17 Tw 0 -1.111 TD (\035\016\021\037\016\035 \025\016\024\024\022\006\f\035\034\006\020\034.\ \216\037\021\035\034\033\034\006 \033\022\024\021\037 \t\202\240 \023)Tj /Span<>> BDC ( )Tj EMC (\201\016\020\235\022\020 \213 \030\036\027\030\026\035\024\030 \036\037\ \013\022\020\037\027\003\020\032\016 \033\034\b\032 \025\016\031 \017\022\ \031\022\005\016\024\021\034\004 )Tj 0.038 Tw 0 -1.111 TD (\033\016\037\025\022\027\022\035\037\007\022\022, \034\024\034\025\016\020\ \020\034 \021\033\023\f\020\032\006 \f\027\034\b\034\006. \205\020\037\027\ \022\031 \027\022\035\016\033\037\035\023\033\032 \024\036\022\b\016\035\ \016\027\003\024\035\036\023\016\035, \005\035\034 \034\f\016\033\037\007\ \022\022 \020\037)Tj /Span<>> BDC ( )Tj EMC (\031\037\b\020\016\004 )Tj 0.076 Tw T* (\024\035\016\020\021\016 \036\027\037\013\037\027\022\235\037, \020\016\031\ \037\036\022\024\022\006\034 \034\035 \035\016\002\020\022\021\022, \024\ )Tj /Span<>> BDC ( )Tj EMC (\036\032\024\034\021\034\004 \005\037\024\035\034\035\034\004 \023\027\023\ \005\001\037\026\035 \024\035\033\023\021\035\023\033\023 \031\037\b\020\ \016\004 \024\035\016\020\021\022 \022)Tj /Span<>> BDC ( )Tj EMC (\024 )Tj 0.164 Tw T* (\006\016\020\003\001\016\004)Tj /Span<>> BDC ( )Tj EMC (\227 \024\020\022\201\037\026\035 \005\037\024\035\034\035\023 \024\022\006\ \f\035\034\006\037\035\022\005\016\024\021\022\002 \f\033\034\030\036\027\ \016\020\022\004 \t\213\221. \203\017\017\016\021\035\022\036\020\034\024\ \035\003 \022\006\f\027\037\020\035\037\007\022\022 \025\022\034)Tj 0 Tw (-)Tj 0.145 Tw T* (\027\034\013\022\005\016\024\021\022\002 \022\027\022 \024\022\020\035\016\ \035\022\005\016\024\021\022\002 \035\033\037\020\024\f\027\037\020\035\037\ \035\034\036 \020\016 \036\032\001\016, \037)Tj /Span<>> BDC ( )Tj EMC (\005\022\024\027\034 \f\034\035\016\020\007\022\037\027\003\020\032\002 \ \034\024\027\034\201\020\016\020\022\004, \036\021\027\026\005\037\030 )Tj 0.009 Tw T* (\b\022\024\f\037\033\016\023\020\022\026 \022)Tj /Span<>> BDC ( )Tj EMC (\220\033\034\031\022\022 \024\022\020\035\016\035\022\005\016\024\021\034\ \013\034 \022\006\f\027\037\020\035\037\035\037)Tj /Span<>> BDC ( )Tj EMC (\227 \036\032\001\016. \207\035\016\f\027\016\033\020\037\030 \035\033\037\ \020\024\037\020\037\027\003\020\037\030 \033\016\031\016\021\007\022\030\ \f\033\030\006\034\004 )Tj 0.019 Tw T* (\021\022\001\021\022 \037\024\024\034\007\022\022\033\034\036\037\020\037\ \024)Tj /Span<>> BDC ( )Tj EMC (\023\027\023\005\001\016\020\022\016\006 \037\020\037\035\034\006\022\022\ \255\207 \022)Tj /Span<>> BDC ( )Tj EMC (\033\037\031\033\016\001\016\020\022\016\006 \207\240\n \f\034\024\027\016\ \036\006\016\001\037\035\016\027\003\024\035\036\037. \217\037)Tj /Span<>> BDC ( )Tj EMC (\024\016\013\034\b\020\030\001)Tj 0 Tw (-)Tj 0.114 Tw T* (\020\022\004 \b\016\020\003 \022\006\016\016\035\024\030 \034\021\034\027\ \034 300 \033\037\031\027\022\005\020\032\002 \035\016\002\020\022\021 \002\ \022\033\023\033\013\022\005\016\024\021\034\013\034 \027\016\005\016\020\ \022\030 \t\213\221. )Tj /Span<>> BDC ( )Tj EMC (2020 \013\034\b\023 \033\037\025\034\005\037\030 \013\033\023\f\f\037 )Tj 0.173 Tw T* (\006\016\201\b\023\020\037\033\034\b\020\034\004 \017\016\b\016\033\037\007\ \022\022 \037\021\023\001\016\033\034\036-\013\022\020\016\021\034\027\034\ \013\034\036 \(FIGO\) \f\033\022)Tj /Span<>> BDC ( )Tj EMC (\037\020\037\027\022\031\016 \022\006\016\026\235\022\002\024\030 \b\037\ \020\020\032\002 \034)Tj /Span<>> BDC ( )Tj EMC (\027\016\005\016\020\022\022 \t\213\221 )Tj 0.045 Tw 0 -1.111 TD (\f\033\022\001\027\037 \021)Tj /Span<>> BDC ( )Tj EMC (\036\032\036\034\b\023, \005\035\034 \035\037\021\035\022\021\037, \f\033\ \016\b\f\034\027\037\013\037\026\235\037\030 \035\033\037\b\022\007\022\034\ \020\020\023\026 \(\024 \f\027\022\021\037\007\022\016\004 \033\016\021\035\ \034\036\037\013\022\020\037\027\003\020\034\004 \017\037\024\007\022\022\ \) )Tj -0.019 Tw 0 -1.111 TD (\031\037\b\020\026\026 \021\034\027\003\f\034\033\033\037\017\022\026 \020\ \037\035\022\036\020\032\006\022 \035\021\037\020\030\006\022 \(\202\255\ \r\217\202\) \025\016\031 \022\024\f\034\027\003\031\034\036\037\020\022\ \030 \024\022\020\035\016\035\022\005\016\024\021\022\002 \022\006\f\027\ \037\020\035\037\035\034\036 \f\033\016\b)Tj 0 Tw (-)Tj -0.019 Tw T* (\f\034\005\035\022\035\016\027\003\020\016\016. \240\b\020\037\021\034 \b\ \037\020\020\032\002 \b\027\030 \034\f\033\016\b\016\027\016\020\022\030\ \220\035\037\027\034\020\020\034\004 \006\016\035\034\b\022\021\022 \002\ \022\033\023\033\013\022\005\016\024\021\034\013\034 \027\016\005\016\020\ \022\030 \t\213\221 \020\016\b\034\024\035\037)Tj 0 Tw (-)Tj 0.023 Tw T* (\035\034\005\020\034, \022)Tj /Span<>> BDC ( )Tj EMC (\036\034\f\033\034\024 \035\033\016\025\023\016\035 \b\034\f\034\027\020\ \022\035\016\027\003\020\034\013\034 \022\031\023\005\016\020\022\030.)Tj /T1_2 1 Tf 0.01 Tc 0.034 Tw 8 0 0 8 70.906 346.3796 Tm [(\037\033\016\r\030\025\f\030)5( \026\033\036\025\021:)]TJ /T1_0 1 Tf 0 Tc 0.039 Tw 8.509 0 Td ( \033\016\021\035\034\007\016\027\016, \f\033\034\027\037\f\024 \035\037\ \031\034\036\032\002 \034\033\013\037\020\034\036, \201\016\020\235\022\020\ \032 \033\016\f\033\034\b\023\021\035\022\036\020\034\013\034 \036\034\031\ \033\037\024\035\037, \027\037\f\037\033\034\024\021\034\f\022\005\016\024\ \021\037\030 \024\037\021\033\034\021\034\027\003\f\034\f\016\033\022)Tj 0 Tw (-)Tj 0.023 Tw -8.514 -1.2 Td (\020\016\034\f\016\021\024\022\030, \031\037\b\020\030\030 \021\034\027\003\ \f\034\033\033\037\017\022\030, \027\016\036\037\035\034\033\034\f\027\037\ \024\035\022\021\037, \033\016\031\016\021\007\022\030 \f\033\030\006\034\ \004 \021\022\001\021\022)Tj /T1_2 1 Tf 0.01 Tc 0.018 Tw 0.005 -1.909 Td [(\037\036\035\034\033\032\037\031)5( \032\035\031\030\027\030\026\036\025:)]TJ /T1_0 1 Tf 0 Tc 0.023 Tw 10.401 0 Td ( \037\036\035\034\033\032 \031\037\030\036\027\030\026\035 \034\025 \034\ \035\024\023\035\024\035\036\022\022 \021\034\020\017\027\022\021\035\037\ \022\020\035\016\033\016\024\034\036)Tj /T1_2 1 Tf 0.02 Tc -0.04 Tw -10.401 -2.617 Td [(\024\033\023)4.7( \022\032\031\032\027\036\025\021\035\032\023:)]TJ /T1_3 1 Tf 0.01 Tc -0.035 Tw 8.925 0 Td ( \204\036\021\030\017\027\f\022\017\005)Tj /Span<>> BDC ( )Tj EMC (\233.\222., \207\036\035\024\031\f\024\r)Tj /Span<>> BDC ( )Tj EMC (\202.\204., \224\017\024\027\036\027\022\024)Tj /Span<>> BDC ( )Tj EMC (\203.\202., \025\024\030\032\031\022)Tj /Span<>> BDC ( )Tj EMC (\204.\224., \204\031\035\036\027\007\036\036\r)Tj /Span<>> BDC ( )Tj EMC (\224.\200. \217\036\022\021\024\006\036\035\036 \031)Tj /Span<>> BDC ( )Tj EMC [(\032\036\027\013\017\027: \027\036\030\036\001\036\027\027\t\036)10.1( )]TJ -8.93 -1.2 Td (\r\024\023\030\024\f\t \(\024\002\024\030 \035\017\021\036\030\026\021\031\ \030\t\). )Tj /T1_0 1 Tf -0.01 Tw (\r\034\027\034\f\033\034\021\035\034\027\034\013\022\030.)Tj /T1_3 1 Tf -0.035 Tw ( 2025; \021.)Tj /Span<>> BDC ( )Tj EMC (24, \223)Tj /Span<>> BDC ( )Tj EMC (4, \f.)Tj /Span<>> BDC ( )Tj EMC (188\226200. https://doi.org/10.33878/2073-7556-2025-24-4-188-200)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0 Tc 0.023 Tw 18 0 0 18 127.2757 258.6332 Tm [(Rectocele in females: unr)31(esolv)12(ed issues \(r)31(e)11(vie)11(w\))]TJ 0 0 0 1 k /GS1 gs 0 Tw 14 0 0 14 70.8661 234.1293 Tm [(Y)50(an\022)-23.3(Y)40(u.\022)-23.3(Metrinsky)]TJ 8.162 0 0 8.162 171.0004 238.7913 Tm (1)Tj 0.023 Tw 14 0 0 14 175.6364 234.1293 Tm [(, Ale)21(x)11(ander\022)-23.2(M.\022)-23.3(Belousov)]TJ 0 Tw 8.162 0 0 8.162 315.0444 238.7913 Tm (1)Tj 0.023 Tw 14 0 0 14 319.6804 234.1293 Tm [(, Nik)11(olay\022)-23.2(A)-31(.\022)-23.3(Siz)10(onenk)11.1(o)]TJ 0 Tw 8.162 0 0 8.162 450.4645 238.7913 Tm (2)Tj 14 0 0 14 455.1004 234.1293 Tm (, )Tj -27.445 -1.143 Td [(Mikhail\022)-23.2(S.\022)-23.3(K)41(or)20(zh)11(uk)]TJ 8.162 0 0 8.162 176.2088 222.7913 Tm (2)Tj 0.023 Tw 14 0 0 14 180.8447 218.1293 Tm [(, Ser)31(gey\022)-23.2(V)62(.\022)-23.3(Mulendee)11(v)]TJ 0 Tw 8.162 0 0 8.162 308.6334 222.7913 Tm (2)Tj 5.83 0 0 5.83 70.8661 203.79 Tm (1)Tj 0.023 Tw 10 0 0 10 74.1775 200.46 Tm [(N.I.\022)-23.3(Pir)20.1(ogov High Medical T)40(echnology Clinic Saint P)10(eter)20(sbur)31(g State Univ)12(er)20(sit)-19.9(y \(F)15(ontanka Riv)12(er embankment, )]TJ -0.331 -1.2 Td [(1)113(5)23(4, Saint P)10(eter)20(sbur)31(g, 1)138(90020, Russia\))]TJ 0 Tw ( )Tj 5.83 0 0 5.83 70.8661 179.7901 Tm (2)Tj 0.023 Tw 10 0 0 10 74.1775 176.4601 Tm [(S.M.\022)-23.3(Kir)20(ov Militar)-30.9(y Medical Academ)21(y \(Akademika Lebede)11(v)10(a\022)-23.2(st., 6G, Saint P)10(eter)20(sbur)31(g, 1)138(9)79.9(40)25.1(44, Russia\))]TJ /T1_0 1 Tf -0.023 Tw 9 0 0 9 119.0551 157.9561 Tm (Among the)Tj /Span<>> BDC ( )Tj EMC (lesions of)Tj /Span<>> BDC ( )Tj EMC [(the per)-37(ineum in w)12(omen, pelvic org)12(an p)46(rolapse occupies a)]TJ /Span<>> BDC ( )Tj EMC [(p)45.9(rominent place. One of)]TJ /Span<>> BDC ( )Tj EMC [(its v)16(ar)-37(iants is )]TJ 0.005 Tw T* (rectocele)Tj /Span<>> BDC ( )Tj EMC [(\227 p)46(ro)13(trusion of)]TJ /Span<>> BDC ( )Tj EMC [(the rectum w)13(all tog)12(ether with the)]TJ /Span<>> BDC ( )Tj EMC [(poster)-37(ior v)16(aginal w)13(all \(PVW\) tow)13(ards the)]TJ /Span<>> BDC ( )Tj EMC [(v)16(agina \(ante)]TJ 0 Tw (-)Tj 0.045 Tw T* [(r)-37(ior )0.6(rectocele\) )0.5(and/or )0.5(along )0.6(the)]TJ /Span<>> BDC ( )Tj EMC 12.886 0 Td [(poster)-36.9(ior )0.5(semicircle )0.7(of)]TJ /Span<>> BDC ( )Tj EMC 8.986 0 Td [(the )0.6(intestine )0.6(\(poster)-37(ior )0.5(rectocele\). )0.6(Anter)-37(ior )0.6(rectocele )0.5(\(AR\) )]TJ 0.094 Tw -21.872 -1.111 Td [(is accom)16(panied by obstructiv)13(e bow)12(el mov)13(ement syndrome \(OBMS\) with sym)16(p)13(toms such as pain, constipation and )]TJ -0.014 Tw T* (the)Tj /Span<>> BDC ( )Tj EMC [(need )0.5(to)]TJ /Span<>> BDC ( )Tj EMC (use a)Tj /Span<>> BDC ( )Tj EMC [(f)-43(ing)12.1(er aid dur)-36.9(ing defecation. )0.5(The)]TJ /Span<>> BDC ( )Tj EMC [(p)46(rev)16(alence )0.5(of)]TJ /Span<>> BDC ( )Tj EMC [(pelvic )0.5(org)12(an p)46(rolapse \(PO)29(P\) among w)12(omen in some )]TJ 0.049 Tw 0 -1.111 TD [(countr)-36.9(ies )0.5(reaches )0.6(50%. )0.6(In )0.6(R)22(ussia, )0.6(this )0.5(f)-42.9(igure )0.5(e)-15(xceeds )0.6(30%. )0.6(W)29(omen )0.6(of)]TJ /Span<>> BDC ( )Tj EMC 27.703 0 Td [(rep)46(roductiv)13(e )0.5(ag)12(e )0.6(\(RA\) )0.6(in )0.6(the)]TJ /Span<>> BDC ( )Tj EMC 11.528 0 Td [(conte)-15(xt )0.6(of)]TJ /Span<>> BDC ( )Tj EMC 4.266 0 Td [(PO)29(P )]TJ 0.02 Tw -43.497 -1.111 Td [(and )0.5(AR )0.5(are )0.6(of)]TJ /Span<>> BDC ( )Tj EMC 5.561 0 Td [(par)-40(ticular )0.6(interest. )0.6(The)]TJ /Span<>> BDC ( )Tj EMC 9.26 0 Td [(disease )0.6(in )0.5(this )0.5(g)14(roup )0.5(is )0.5(asym)16(p)13(tomatic )0.5(for )0.5(a)]TJ /Span<>> BDC ( )Tj EMC [(long )0.5(time. )0.5(A)]TJ /Span<>> BDC ( )Tj EMC 22.056 0 Td [(r)-37(isk )0.5(factor )0.5(for )0.5(PO)29(P )0.5(in )]TJ 0.006 Tw -36.878 -1.111 Td [(RA-w)12(omen )0.6(is )0.6(v)16(aginal )0.6(deliv)13(er)-43(y )0.6(without )0.6(ph)12(ysical )0.6(rehabilitation, )0.7(especially )0.6(with )0.6(a)]TJ /Span<>> BDC ( )Tj EMC 30.759 0 Td [(larg)12(e )0.6(fetus. )0.6(An)]TJ /Span<>> BDC ( )Tj EMC 5.967 0 Td [(analysis )0.6(of)]TJ /Span<>> BDC ( )Tj EMC 4.417 0 Td [(the )0.6(litera)]TJ 0 Tw (-)Tj ET 1 0.68 0 0.12 k /GS0 gs q 1 0 0 1 70.8661 570.1533 cm 0 0 m 0 0 l 0 -11.339 l 42.52 -11.339 l 42.52 0 l h f Q BT 0 0 0 0 k /T1_2 1 Tf 9 0 0 9 76.0071 561.226 Tm (\027\030\013\016\n\030)Tj ET 1 0.68 0 0.12 k q 1 0 0 1 70.8661 166.4604 cm 0 0 m 0 0 l 0 -11.339 l 42.52 -11.339 l 42.52 0 l h f Q BT 0 0 0 0 k /T1_2 1 Tf 9 0 0 9 73.5728 157.5332 Tm (ABSTRACT)Tj 1 0.68 0 0.12 k /T1_1 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\206)10(\002\036\033 \035\030\032\003\033)30(\n)42(\032)-21(\230\033\241)]TJ 57.136 0 Td (REVIEW)Tj -57.136 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 2)69(4, \023\0224, 202)23(5)]TJ 43.013 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 2)69(4, \023\0224, 202)23(5)]TJ /T1_4 1 Tf 25 0 0 25 20.8152 56.0378 Tm (188)Tj ET q 0 g 0 G 0 j 0 J /Fm1 Do Q 0 0 0 0 k 396.85 725.67 59.155 11.338 re f /PlacedPDF /MC0 BDC q 397.481 736.808 m 397.242 736.808 397.049 736.616 397.049 736.376 c 397.049 736.376 l 397.049 726.285 l 397.049 726.045 397.242 725.853 397.481 725.853 c 397.481 725.853 l 455.382 725.853 l 455.62 725.853 455.815 726.045 455.815 726.285 c 455.815 726.285 l 455.815 736.376 l 455.815 736.616 455.62 736.808 455.382 736.808 c 455.382 736.808 l h W n q 0 g -0.0000005 -10.9560913 -10.9560913 0.0000005 426.4320445 736.8086309 cm BX /Sh0 sh EX Q Q q 396.85 725.67 59.155 11.337 re W n 0 0 0 0.84 k q 1 0 0 1 413.5634 732.4249 cm 0 0 m -0.025 0.1 -0.063 0.196 -0.112 0.287 c -0.157 0.374 -0.218 0.451 -0.292 0.515 c -0.37 0.582 -0.46 0.632 -0.558 0.664 c -0.669 0.701 -0.786 0.719 -0.903 0.717 c -1.076 0.722 -1.247 0.681 -1.4 0.6 c 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Dia)-17(gnost)-32(ic v)-15(ar)-37(i)]TJ 0 Tw (-)Tj 0.152 Tw -1.796 -1.25 Td [(abil)-31(i)-23.9(t)-10(y in t)-12.9(he)]TJ /Span<>> BDC ( )Tj EMC [(hist)17(op)32(a)15(t)-13(hol)30(o)-16(gical assess)26.1(ment of)]TJ /Span<>> BDC ( )Tj EMC [(ad)-17(v)-15(anced col)30(or)-24(ec)-16(t)15(al )]TJ 0.226 Tw T* [(adenomas )0.5(and )0.5(ear)-30(l)35(y )0.5(col)30(or)-24(ec)-15.9(t)15(al )0.5(cancer )0.5(in )0.5(a)]TJ /Span<>> BDC ( )Tj EMC 18.54 0 Td [(scr)-24(eening )0.5(popul)-15.9(a)15(t)-32(ion. )]TJ /T1_2 1 Tf 0 Tw -18.54 -1.25 Td (Histopathology)Tj /T1_1 1 Tf 0.023 Tw [(. 2022;80: 790\226798. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1111/his.14601)Tj 0 0 0 1 k /GS1 gs 0.072 Tw T* (76.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Dyk)-10(str)-32.9(a MA, )0.5(Gimon TI, )0.5(R)11(onk)-10(sle)-11(y )0.5(PE, )0.5(e)-12(t al. )0.5(Cl)-16(assic )0.5(and )0.5(novel his)]TJ 0 Tw (-)Tj 0.077 Tw -1.796 -1.25 Td [(t)17(op)32(a)15(t)-13(hol)30(o)-15.9(gic r)-37(isk )0.5(f)16(a)-17(c)-16(t)17(or)-10(s for )0.5(l)35(ym)10(ph node )0.5(me)-12(t)15(ast)15(asis in )0.5(T1 col)30(or)-24(ec)-16(t)15(al )]TJ 0.188 Tw T* [(cancer: )0.5(A)]TJ /Span<>> BDC ( )Tj EMC 4.329 0 Td [(sy)-13(stema)15.1(t)-32(ic )0.5(r)-24(ev)-16(iew )0.5(and )0.5(me)-12(t)15(a-anal)35(y)-12.9(sis. )]TJ /T1_2 1 Tf 15.962 0 Td [(Dis )0.5(Colon )0.5(R)21(ectum.)]TJ /T1_1 1 Tf 0 Tw ( )Tj 0.023 Tw -20.291 -1.25 Td [(\(2021\)64:1139\22650. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1097/DCR.0000000000002164)Tj 0 0 0 1 k /GS1 gs 0.031 Tw T* (77.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Miy)22(a)-17(chi )0.6(H, )0.5(K)25(ud)-16(o )0.6(S, )0.5(Ichimasa )0.6(K, )0.6(e)-12(t )0.5(al. )0.5(Mana)-17(gement )0.6(of)]TJ /Span<>> BDC ( )Tj EMC 21.356 0 Td [(T1 )0.5(col)30.1(or)-24(ec)]TJ 0 Tw (-)Tj 0.079 Tw -23.152 -1.25 Td [(t)15(al cancer)-10(s af)-28(ter end)-16(oscopic tr)-24(ea)15(tment based on t)-12.9(he)]TJ /Span<>> BDC ( )Tj EMC [(r)-36.9(isk str)-33(a)15(t)-32(if)-28(ica)]TJ 0 Tw (-)Tj 0.308 Tw T* [(t)-32(ion of)]TJ /Span<>> BDC ( )Tj EMC [(l)35(ym)10.1(ph node me)-11.9(t)15(ast)15(asis. )]TJ /T1_2 1 Tf [(Jour)-13.9(nal of)]TJ /Span<>> BDC ( )Tj EMC (Gastroenterology and )Tj 0 Tw T* (Hepatology.)Tj /T1_1 1 Tf 0.023 Tw [( 2016;31\(6\):1126\2261132. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1111/jgh.13257)Tj 0 0 0 1 k /GS1 gs 0.141 Tw T* (78.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Gijsber)-9.9(s K, de G)20(r)-33(aaf W, M)-24(o)-16(ons LMG, e)-12(t al. High p)25(r)-33(a)-17(c)-16(t)-32(ice v)-15(ar)-37(ia)]TJ 0 Tw (-)Tj 0.096 Tw -1.796 -1.25 Td [(t)-32(ion in r)-37(isk str)-32.9(a)15(t)-32(if)-28(ica)15(t)-32(ion, basel)-31(ine oncol)30(o)-16(gical st)15(a)-17(ging, and foll)30(o)-14(w-)]TJ 0.297 Tw T* [(up str)-33(a)15(tegies for T1 col)30(or)-24(ec)-16(t)15(al cancer)-9.9(s in t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(Ne)-12(t)-13(her)-29.9(l)-16(ands. \(on )]TJ 0.102 Tw T* [(behalf )0.5(of)]TJ /Span<>> BDC ( )Tj EMC [(t)-12.9(he Dutch )0.5(T1 )0.5(CRC W)20(or)-23.9(k)-16(ing G)20(r)-32(oup\). )]TJ /T1_2 1 Tf [(Endosc )0.5(Int )0.5(Open.)]TJ /T1_1 1 Tf [( )0.5(2020 )]TJ 0.023 Tw T* [(Sep;8\(9\):E1117\226E1122. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1055/a-1192-3545)Tj 0 0 0 1 k /GS1 gs 0.252 Tw 29.055 36.25 Td (79.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(K)25(ouy)22(ama Y, K)25(ud)-15.9(o S, Ichimasa K, e)-12(t al. End)-16(oscopic r)-24(esec)-15.9(t)-32(ion )]TJ 0.323 Tw -1.796 -1.25 Td [(al)30(one as a)]TJ /Span<>> BDC ( )Tj EMC [(po)17(tent)-32(ial tr)-23.9(ea)15(tment me)-11.9(t)-13(hod for l)30(o)-13.9(w-r)-37(isk deep inv)-15(a)]TJ 0 Tw (-)Tj 0.078 Tw T* [(si)-16(ve T1 col)30(or)-24(ec)-16(t)15(al cancer. )]TJ /T1_2 1 Tf 0 Tw (iGIE.)Tj /T1_1 1 Tf 0.078 Tw [( 2023;2\(4\):503\226509. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1016/j.)Tj T* (igie.2023.09.007)Tj 0 0 0 1 k /GS1 gs 0.16 Tw T* (80.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(T)40(anino )0.6(F, )0.5(Y)50(amashi)-23.9(t)15(a )0.5(K, )0.6(M)-24(or)-37(imo)17(t)17(o )0.6(S, )0.5(e)-12(t )0.6(al. )0.6(Com)10(p)32(ar)-33(a)15(t)-32(i)-16(ve )0.6(p)25(r)-24(edic)]TJ 0 Tw (-)Tj 0.314 Tw -1.796 -1.25 Td [(t)-32(ion of)]TJ /Span<>> BDC ( )Tj EMC [(l)35(ym)10(ph node me)-12(t)15(ast)15(asis in pT1 col)30(or)-24(ec)-16(t)15(al cancer among )]TJ 0.239 Tw T* [(W)22(ester)-15(n and Jap)32(anese guidel)-31(ines. )]TJ /T1_2 1 Tf [(F)27(ront Oncol.)]TJ /T1_1 1 Tf ( 2024;14:1475270. )Tj 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.3389/fonc.2024.1475270)Tj 0 0 0 1 k /GS1 gs 0.008 Tc 0.35 Tw -1.847 -1.25 Td (81.)Tj /Span<>> BDC ( )Tj EMC 1.828 0 Td [(P)10(ont)15(ar)-32(oll)30(o )0.5(G,\300Bonjour)-16(m )0.5(M, )0.5(W)12(al)56(ter )0.5(T. )0.5(Hist)17(op)25(r)-32(onost)-32(ic )0.5(f)16(a)-17(c)-16(t)17(or)-10(s)8( )]TJ 0 Tc 0.281 Tw -1.828 -1.25 Td [(in super)-24(f)-27.9(ic)-24(ial col)30(or)-24(ec)-16(t)15(al adeno)-16(car)-31.9(c)-24(inomas tr)-24(ea)15(ted b)12(y end)-16(oscopy: )]TJ 0.007 Tc 0.349 Tw T* [(r)-23.7(ep)25.3(r)-31.7(oduc)-23.7(ibil)-30.8(i)-23.7(t)-9.7(y and im)10.3(p)32.2(a)-16.7(c)-15.8(t of)]TJ /Span<>> BDC ( )Tj EMC [(immunohist)17.3(o)-15.8(chemistr)-23.7(y and digi)]TJ 0 Tc 0 Tw (-)Tj 0.252 Tw T* [(t)15(al p)32(a)15(t)-13(hol)30.1(o)-16(g)16(y. )]TJ /T1_2 1 Tf (Virchows Archiv.)Tj /T1_1 1 Tf [( 2024;485:233\226244. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1007/)Tj T* (s00428-023-03722-3)Tj 0 0 0 1 k /GS1 gs -0.041 Tw T* (82.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(K)-16(ajiw)-11.9(ar)-33(a Y, Ok)-17(a S, T)40(anak)-17(a S, e)-11.9(t al. N)-14(omo)-16(gr)-32.9(am as a)]TJ /Span<>> BDC ( )Tj EMC [(novel p)25(r)-24(edic)-16(t)-31.9(i)-16(ve )]TJ 0.081 Tw -1.796 -1.25 Td [(t)17(o)-16(ol for l)35(ym)10(ph node me)-12(t)15(ast)15(asis in T1 col)30(or)-24(ec)-16(t)15.1(al cancer tr)-24(ea)15(ted wi)-24(t)-13(h )]TJ 0.093 Tw T* [(end)-16(oscopic r)-23.9(esec)-16(t)-32(ion: a)]TJ /Span<>> BDC ( )Tj EMC [(na)15(t)-31.9(ionwide, mul)56(t)-32(icenter stud)17(y. )]TJ /T1_2 1 Tf 0 Tw (Gastrointest )Tj T* (Endosc)Tj /T1_1 1 Tf 0.023 Tw [(. 2023;97:1119\2261128.e5. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1016/j.gie.2023.01.022)Tj 0 0 0 1 k /GS1 gs 0.01 Tc 0.361 Tw T* (83.)Tj /Span<>> BDC ( )Tj EMC 1.835 0 Td [(Y)50.3(an S, Ding H, Zhao X, e)-11.6(t al.Devel)30.4(opment and v)-14.6(al)-30.6(id)42.4(a)15.3(t)-31.6(ion)10( )]TJ 0 Tc 0.005 Tw -1.835 -1.25 Td (of)Tj /Span<>> BDC ( )Tj EMC (a)Tj /Span<>> BDC ( )Tj EMC [(nomo)-15.9(gr)-33(am for fur)-22(t)-13(her dec)-23.9(ision of)]TJ /Span<>> BDC ( )Tj EMC [(r)-33(adical sur)-32(ger)-23.9(y in pT1 col)30(or)-24(ec)]TJ 0 Tw (-)Tj 0.089 Tw T* [(t)15(al cancer af)-28(ter l)30(o)-16(cal r)-24(esec)-16(t)-32(ion. )]TJ /T1_2 1 Tf (Int J Colorectal Dis.)Tj /T1_1 1 Tf ( 2021;36:1499\226)Tj 0.023 Tw T* [(506. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1007/s00384-021-03928-4)Tj 0 0 0 1 k /GS1 gs 0.158 Tw T* (84.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Ichimasa K, K)25(ud)-16(o SE, M)-24(or)-36.9(i Y, e)-12(t al. Ar)-22(t)-32(if)-28(ic)-23.9(ial intell)-31(igence ma)15(y )]TJ 0.078 Tw -1.796 -1.25 Td [(help in p)25(r)-24(edic)-16(t)-32(ing t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(need for addi)-23.9(t)-32(ional sur)-32(ger)-24(y af)-28(ter end)-16(oscopic )]TJ 0.005 Tc 0.35 Tw T* [(r)-24.3(esec)-16.3(t)-32.2(ion of)]TJ /Span<>> BDC ( )Tj EMC [(T1 col)29.7(or)-24.3(ec)-16.2(t)14.7(al cancer. )]TJ /T1_2 1 Tf -0.005 Tw [(Endoscop)11.7(y)]TJ /T1_1 1 Tf 0.35 Tw [(. 2018;50:230\22640.)5( )]TJ 0 Tc 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1055/s-0043-122385)Tj 0 0 0 1 k /GS1 gs 0.074 Tw -1.847 -1.25 Td (85.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(K)25(ud)-16(o )0.5(SE, )0.5(Ichimasa )0.5(K, )0.5(V)-15(ill)-16(ar)-23.9(d )0.5(B, e)-11.9(t )0.5(al. 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Ar)-24(ea of)]TJ /Span<>> BDC ( )Tj EMC (submucosal )Tj 0.163 Tw -1.796 -1.25 Td [(inv)-15(asion and wid)17(t)-12.9(h of)]TJ /Span<>> BDC ( )Tj EMC [(inv)-14.9(asion p)24.9(r)-23.9(edic)-16(ts l)35(ym)10(ph node me)-12(t)15(ast)15(asis in )]TJ 0.003 Tc 0.349 Tw 0 -1.25 TD [(pT1 col)30.4(or)-23.6(ec)-15.7(t)15.4(al cancer)-9.6(s. )]TJ /T1_1 1 Tf [(Dis Colon R)21.3(ectum.)]TJ /T1_0 1 Tf [( 2015;58\(4\):393\226340.)3.1( )]TJ 0 Tc 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1097/DCR.0000000000000315)Tj 0 0 0 1 k /GS1 gs 0.255 Tw -1.847 -1.25 Td (40.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Egashir)-32.9(a Y, )0.6(Y)40(oshid)42(a T, )0.6(Hir)-33(a)15(t)15(a )0.5(I, )0.5(e)-12(t )0.5(al. )0.5(Anal)35(y)-12.9(sis )0.5(of)]TJ /Span<>> BDC ( )Tj EMC 21.664 0 Td [(p)32(a)15(t)-13(hol)30(o)-15.9(gi)]TJ 0 Tw (-)Tj 0.172 Tw -23.46 -1.25 Td [(cal r)-37(isk f)16(a)-16.9(c)-16(t)17(or)-10(s for l)35(ym)10(ph node me)-12(t)15(ast)15(asis of)]TJ /Span<>> BDC ( )Tj EMC [(submucosal inv)-15(asi)-16(ve )]TJ 0.094 Tw T* [(col)30(on cancer. )]TJ /T1_1 1 Tf [(Mod P)17.9(athol.)]TJ /T1_0 1 Tf [( 2004;17\(5\):503\226511. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1038/mod)Tj (-)Tj T* [(p)32(a)15(t)-13(hol.3800030)]TJ 0 0 0 1 k /GS1 gs 0.142 Tw T* (41.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(W)12(ang LM, Guy R, F)10.1(r)-24(yer E, e)-12(t al. T)47(he)]TJ /Span<>> BDC ( )Tj EMC [(Ueno me)-12(t)-13(hod for subst)15.1(a)-17(g)]TJ 0 Tw (-)Tj 0.009 Tc 0.351 Tw -1.796 -1.25 Td [(ing pT1 col)29.7(or)-24.3(ec)-16.3(t)14.7(al adeno)-16.3(car)-32.3(c)-24.4(inoma b)11.7(y dept)-13.3(h and wid)16.6(t)-13.3(h mea)]TJ 0 Tc 0 Tw (-)Tj 0.198 Tw T* [(sur)-24(ement: )0.6(an)]TJ /Span<>> BDC ( )Tj EMC [(inter)-31.9(obser)-32(ver )0.5(stud)17(y. )]TJ /T1_1 1 Tf 14.648 0 Td [(Color )0.5(Dis.)]TJ /T1_0 1 Tf ( 2015;17\(8\):674\226681. )Tj 0 Tw -14.648 -1.25 Td [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1111/codi.12910)Tj 0 0 0 1 k /GS1 gs 0.127 Tw -1.847 -1.25 Td (42.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Ma)15(ynovsk)-17(a)15.1(y)22(a O, R)-20(ybakov )0.5(E, Cher)-15(ny)-13(shov S, e)-12(t al. Ar)-24(e t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(wid)17.1(t)-13(h, )]TJ 0.084 Tw -1.796 -1.25 Td [(leng)17(t)-13(h, dept)-12.9(h, and ar)-24(ea of)]TJ /Span<>> BDC ( )Tj EMC [(submucosal inv)-14.9(asion p)25(r)-24(edic)-16(t)-31.9(i)-16(ve of)]TJ /Span<>> BDC ( )Tj EMC [(l)35(ym)10(ph )]TJ 0.014 Tc 0.502 Tw T* [(node me)-11.6(t)15.3(ast)15.3(asis in pT1 col)30.4(or)-23.6(ec)-15.6(t)15.3(al cancer? )]TJ /T1_1 1 Tf [(Ann Colop)46.4(roctol.)]TJ /T1_0 1 Tf 0 Tc 0 Tw 27.638 0 Td ( )Tj -27.638 -1.25 Td (2023;39\(6\):484\226492.)Tj 0.112 Tw T* (43.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(W)12(ad)42(a H, S)-16(hioza)10(w)-12(a M, K)-16(a)15(t)15(a)15(y)22(ama K, e)-11.9(t al. 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L)70(yon \(F)10(r)-32.9(ance\): Inter)-14.9(na)15(t)-32(ional a)-17(gency for R)13(esear)-32(ch on )]TJ 0.29 Tw -4.916 -1.25 Td [(Cancer; 2019. ht)-30(tps://www.iar)-31.8(c.who.int/news-events/publ)-30.9(ica)15.1(t)-32(ion-)]TJ 0.011 Tc -0.011 Tw T* [(o)0.5(f)0.6(-)0.5(w)0.5(h)0.5(o)0.6(-)0.5(c)0.5(l)-15.4(a)0.5(s)0.5(s)0.5(i)0.6(f)-27.5(i)0.5(c)0.6(a)15.5(t)-31.5(i)0.5(o)0.6(n)0.5(-)0.5(o)0.5(f)0.6(-)0.5(t)0.5(u)0.6(m)0.5(o)0.5(u)0.5(r)-9.4(s)0.5(-)0.5(5)0.6(t)-12.5(h)0.5(-)0.6(e)0.5(d)0.5(i)-23.4(t)-31.5(i)0.5(o)0.5(n)0.6(-)0.5(v)0.5(o)0.5(l)35.6(u)0.5(m)0.5(e)0.6(-)0.5(1)0.5(-)0.5(d)0.6(i)0.5(g)0.5(e)0.5(s)0.6(t)-31.5(i)-15.5(v)0.6(e)0.5(-)]TJ 0 Tc 0 Tw T* [(sy)-13(stem-tumour)-9.9(s/)]TJ 0.234 Tw T* (51.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Q)-16(uir)-24(k)10(e P, R)-24(isio M, L)-32(amber)-21.9(t R, e)-12(t al. Eur)-31.9(opean guidel)-31(ines for )]TJ 0.023 Tw -1.796 -1.25 Td [(qual)-31(i)-23.9(t)-10(y assur)-32.9(ance )0.5(in )0.5(col)30(or)-24(ec)-16(t)15(al )0.5(cancer )0.5(scr)-24(eening )0.5(and )0.5(dia)-17(gnosis. )0.5(F)-19(ir)-9.9(st )]TJ -0.031 Tw T* [(Edi)-24(t)-32(ion Q)-16(ual)-31(i)-24(t)-9.9(y assur)-33(ance in p)32(a)15(t)-13(hol)30(o)-16(g)16(y in col)30(or)-24(ec)-16(t)15(al cancer scr)-24(eening )]TJ 0.212 Tw T* [(and dia)-17(gnosis. )]TJ /T1_1 1 Tf 0 Tw [(Endoscop)12.1(y)]TJ /T1_0 1 Tf 0.212 Tw [(. 2012;44:SE116\226SE130. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1055/s-)Tj T* (0032-1309797)Tj 0 0 0 1 k /GS1 gs 0.014 Tw T* (52.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Car)-24(e)-11(y F, Newbold M, Q)-16(uir)-23.9(k)10(e P, e)-11.9(t al. R)13(epor)-22(t)-31.9(ing lesions in t)-12.9(he)]TJ /Span<>> BDC ( )Tj EMC (NHS )Tj 0.309 Tw -1.796 -1.25 Td [(Bo)-14(wel )0.6(Cancer )0.6(S)-24(cr)-24(eening )0.6(P)35(r)-32(o)-16(gr)-33(amme: )0.6(Guidel)-30.9(ines )0.5(fr)-31.9(om )0.5(t)-13(he)]TJ /Span<>> BDC ( )Tj EMC 25.222 0 Td [(Bo)-14(wel )]TJ 0.004 Tc 0.349 Tw -25.222 -1.25 Td [(Cancer S)-23.8(cr)-23.9(eening P)35.1(r)-31.8(o)-15.9(gr)-32.8(amme P)40.2(a)15.1(t)-12.8(hol)30.2(o)-15.9(g)16.2(y G)20.2(r)-31.8(oup 2007;1\22624. NHS)4( )]TJ 0 Tc 0.037 Tw T* [(BCSP publ)-30.9(ica)15(t)-32(ion A)15(v)-15(ail)-16(able a)15(t: ht)-30(tp://www.cancer)-9.9(scr)-24(eening.nhs.uk/)]TJ 0 Tw T* [(bo)-14(wel/publ)-30.9(ica)15(t)-32(ions/nhsbcsp01.pdf)]TJ 0.011 Tc 0.417 Tw T* (53.)Tj /Span<>> BDC ( )Tj EMC 1.841 0 Td [(Ueno H, Mur)-24.2(phy J, Jass JR, e)-12.2(t al. T)59.7(umour \247budding\246 as)11( )]TJ 0 Tc 0.33 Tw -1.841 -1.25 Td (an)Tj /Span<>> BDC ( )Tj EMC [(inde)-17.9(x t)17(o)]TJ /Span<>> BDC ( )Tj EMC [(est)-31.9(ima)15(te t)-13(he)]TJ /Span<>> BDC ( )Tj EMC 11.715 0 Td [(po)17(tent)-32(ial )0.5(of)]TJ /Span<>> BDC ( )Tj EMC [(a)-17(ggr)-24(essi)-15.9(veness )0.5(in r)-24(ec)-16(t)15(al )]TJ 0.007 Tc -0.007 Tw -11.715 -1.25 Td (cancer. )Tj /T1_1 1 Tf 3.574 0 Td (Histopathology.)Tj /T1_0 1 Tf 0.35 Tw [( 2002;40:127\226132. d)-16.2(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs -0.007 Tw (10.1046/j.1365-)Tj 0 Tc 0 Tw -3.574 -1.25 Td (2559.2002.01324.x)Tj 0 0 0 1 k /GS1 gs -0.026 Tw T* (54.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Ueno )0.5(H, )0.6(K)-16(ajiw)-12(ar)-33(a )0.6(Y, )0.5(S)-16(hima)-24(zak)-15.9(i )0.5(H, )0.5(e)-12(t )0.6(al. )0.5(New )0.6(cr)-37(i)-24(ter)-37(ia )0.6(for )0.5(hist)17.1(ol)30(o)-16(gic )]TJ 0.148 Tw -1.796 -1.25 Td [(gr)-33(ading of)]TJ /Span<>> BDC ( )Tj EMC [(col)30(or)-24(ec)-16(t)15(al cancer. )]TJ /T1_1 1 Tf [(Am J Surg P)18(athol.)]TJ /T1_0 1 Tf ( 2012;36:193\226201. )Tj 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td [(10.1097/P)25(A)35(S.0b013e318235edee)]TJ 0 0 0 1 k /GS1 gs 0.019 Tc 0.673 Tw 27.208 81.25 Td [(55)0.5(.)]TJ /Span<>> BDC ( )Tj EMC 1.87 0 Td [(A)0.5(k)-15.6(i)0.5(sh)0.5(ima)0.5(-F)10.5(uk)-16.5(as)0.5(a)10.4(w)-11.5(a )0.5(Y)0.5(, )0.5(I)0.5(shi)0.5(k)-16.6(a)10.5(w)-11.6(a)0.5( )0.5(Y,)0.5( )0.5(Ak)-16.5(as)0.5(ak)-16.5(a )0.5(Y)0.5(, )0.5(e)-11.5(t )0.5(al)0.5(.)19( )]TJ 0.003 Tc 0.35 Tw -1.87 -1.25 Td [(Hist)16.6(op)31.7(a)14.6(t)-13.4(hol)29.6(o)-16.4(gical p)24.6(r)-24.4(edic)-16.3(t)16.6(or)-10.4(s of)]TJ /Span<>> BDC ( )Tj EMC [(r)-24.4(egional l)34.6(ym)9.7(ph node me)-12.4(t)14.6(ast)14.6(asis)3( )]TJ 0 Tc 0.299 Tw T* [(a)15(t t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(inv)-15(asi)-16(ve fr)-32(ont in ear)-29.9(l)35(y col)30(or)-23.9(ec)-16(t)15(al cancer. )]TJ /T1_1 1 Tf 0 Tw (Histopathology)Tj /T1_0 1 Tf (. )Tj 0.023 Tw T* [(2011;59:470\226481. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1111/j.1365-2559.2011.03964.x)Tj 0 0 0 1 k /GS1 gs 0.165 Tw T* (56.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(R)11(o)-16(ger)-10(s A)16(C, W)-16(inter DC, Heene)-11(y A, e)-12(t al. Sy)-13(stema)15.1(t)-32(ic r)-24(ev)-16(iew and )]TJ 0.036 Tw -1.796 -1.25 Td [(me)-12(t)15(a-anal)35.1(y)-13(sis of)]TJ /Span<>> BDC ( )Tj EMC [(t)-13(he im)10(p)32(a)-17(c)-16(t of)]TJ /Span<>> BDC ( )Tj EMC [(tumour budding in col)30.1(or)-24(ec)-16(t)15(al cancer. )]TJ /T1_1 1 Tf -0.032 Tw T* (Br J Cancer.)Tj /T1_0 1 Tf [( 2016; Sep 27;115\(7\):831\22640. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1038/bjc.2016.274)Tj 0 0 0 1 k /GS1 gs 0.304 Tw T* (57.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Cappellesso R, L)35(uchini C, V)30(er)-31.9(onese N, e)-12(t al. T)60(umor budding )]TJ 0.299 Tw -1.796 -1.25 Td (as a)Tj /Span<>> BDC ( )Tj EMC [(r)-37(isk f)16(a)-17(c)-16(t)17(or for nod)42(al me)-12(t)15(ast)15.1(asis in pT1 col)30.1(or)-24(ec)-16(t)15(al cancer)-10(s: )]TJ 0.139 Tw T* (a)Tj /Span<>> BDC ( )Tj EMC [(me)-12(t)15.1(a-anal)35(y)-13(sis. )]TJ /T1_1 1 Tf [(Hum P)18(athol.)]TJ /T1_0 1 Tf [( 2017;65:62\22670. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1016/j.hum)Tj (-)Tj T* [(p)32(a)15(t)-13(h.2017.04.013)]TJ 0 0 0 1 k /GS1 gs 0.089 Tw T* (58.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(P)20(upp)32(a G, Senor)-24(e C, S)-16(heahan K, e)-12(t al. Dia)-17(gnost)-32(ic r)-24(ep)25(r)-32(oduc)-23.9(ibil)-31(i)-24(t)-10(y )]TJ 0.024 Tw -1.796 -1.25 Td (of)Tj /Span<>> BDC ( )Tj EMC [(tumour budding in col)30(or)-24(ec)-16(t)15.1(al cancer: a)]TJ /Span<>> BDC ( )Tj EMC [(mul)56(t)-32(icentr)-23.9(e, mul)56.1(t)-32(ina)15(t)-32(ional )]TJ 0.023 Tw T* [(stud)17(y using v)-16(ir)-22(tual micr)-32(oscopy. )]TJ /T1_1 1 Tf 0 Tw (Histopathology)Tj /T1_0 1 Tf 0.023 Tw (. 2012;61:562\226575.)Tj 0.124 Tw T* (59.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(L)35(ugl)-31(i)]TJ /Span<>> BDC ( )Tj EMC [(A, Kir)-9.9(sch R, Ajiok)-16.9(a Y, e)-12(t al. R)13(ecommend)42(a)15(t)-32(ions for r)-24(epor)-22(t)]TJ 0 Tw (-)Tj 0.111 Tw -1.796 -1.25 Td [(ing tumor budding in col)30(or)-24(ec)-15.9(t)15(al cancer based on t)-12.9(he)]TJ /Span<>> BDC ( )Tj EMC [(Inter)-15(na)15(t)-32(ional )]TJ 0.247 Tw T* [(T)60(umor Budding Consensus Confer)-24(ence \(ITBCC\) 2016. )]TJ /T1_1 1 Tf [(Mod P)18(athol.)]TJ /T1_0 1 Tf 0 Tw ( )Tj 0.023 Tw T* [(2017;30:1299\226311. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw [(10.1038/modp)32(a)15(t)-13(hol.2017.46)]TJ 0 0 0 1 k /GS1 gs 0.096 Tw T* (60.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Bar)-24(r)-23.9(esi V, Br)-32.9(anca G, Ieni A, e)-12(t al. P)10(o)-16(or)-30(l)35(y dif)-56(fer)-23.9(ent)-32(ia)15(ted cl)35(uster)-10(s )]TJ 0.106 Tw -1.796 -1.25 Td (\(PDCs\) as a)Tj /Span<>> BDC ( )Tj EMC [(novel hist)17(ol)30(o)-16(gical p)25(r)-24(edic)-16(t)17.1(or of)]TJ /Span<>> BDC ( )Tj EMC [(nod)42(al me)-12(t)15(ast)15(ases in pT1 )]TJ 0.099 Tw T* [(col)30(or)-24(ec)-15.9(t)15(al )0.5(cancer. )]TJ /T1_1 1 Tf 7.581 0 Td [(Virchows )0.6(Arch.)]TJ /T1_0 1 Tf [( )0.5(2014;464:655\226662. )0.5(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw 16.318 0 Td (10.1007/)Tj -23.899 -1.25 Td (s00428-014-1580-z)Tj 0 0 0 1 k /GS1 gs 0.041 Tw T* (61.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(R)13(eggiani Bone)-12(t)-30(t)-32(i L, Bar)-23.9(r)-24(esi V, Be)-11.9(t)-30(tell)-31(i S, e)-12(t al. P)10(o)-16(or)-30(l)35(y dif)-56(fer)-23.9(ent)-32(i)]TJ 0 Tw (-)Tj 0.175 Tw -1.796 -1.25 Td [(a)15(ted cl)35(uster)-9.9(s \(PDC\) in col)30(or)-24(ec)-16(t)15(al cancer: wha)15(t is and ought t)17(o)]TJ /Span<>> BDC ( )Tj EMC (be )Tj 0 Tw T* [(kno)-14(wn. )]TJ /T1_1 1 Tf 0.023 Tw 3.181 0 Td [(Diagn P)18(athol)]TJ /T1_0 1 Tf [(. 2016;11:31. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1186/s13000-016-0481-7)Tj 0 0 0 1 k /GS1 gs -3.181 -1.25 Td (62.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(K)25(onishi T, S)-16(himad)42(a Y, L)35(ee LH, e)-12(t al. P)10(o)-16(or)-29.9(l)35(y Dif)-56(fer)-23.9(ent)-32(ia)15(ted Cl)35(uster)-9.9(s )]TJ 0.066 Tw -1.796 -1.25 Td [(P)35(r)-24(edic)-15.9(t Col)30(on Cancer R)13(ecur)-24(r)-24(ence: )0.5(An)]TJ /Span<>> BDC ( )Tj EMC [(In-Dept)-13(h Com)10(p)32(ar)-32.9(a)15(t)-32(i)-16(ve Anal)35(y)-13(sis )]TJ 0.026 Tw T* (of)Tj /Span<>> BDC ( )Tj EMC [(Inv)-15(asi)-15.9(ve-F)10(r)-32(ont P)35(r)-31.9(o)-16(gnost)-32(ic Mar)-23.9(k)9.9(er)-9.9(s. )]TJ /T1_1 1 Tf [(Am J Surg P)18(athol)]TJ /T1_0 1 Tf (. 2018; June; )Tj 0.023 Tw T* [(42\(6\):705\226714. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw [(10.1097/P)25(A)35(S.0000000000001059)]TJ 0 0 0 1 k /GS1 gs 0.113 Tw T* (63.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(S)-16(hi)-16(vji )0.6(S, Conner JR, )0.6(Bar)-24(r)-24(esi )0.5(V, )0.5(e)-12(t )0.5(al. )0.5(P)10(o)-16(or)-30(l)35(y )0.5(dif)-55.9(fer)-24(ent)-32(ia)15(ted )0.5(cl)35(us)]TJ 0 Tw (-)Tj 0.288 Tw -1.796 -1.25 Td [(ter)-10(s )0.6(in )0.5(col)30(or)-24(ec)-16(t)15.1(al )0.5(cancer: )0.6(a)]TJ /Span<>> BDC ( )Tj EMC 12.314 0 Td [(cur)-24(r)-23.9(ent )0.5(r)-24(ev)-15.9(iew )0.5(and )0.5(im)10(pl)-30.9(ica)15(t)-32(ions )0.5(for )]TJ 0.018 Tw -12.314 -1.25 Td [(futur)-23.9(e p)25(r)-33(a)-17(c)-16(t)-32(ice. )]TJ /T1_1 1 Tf 0 Tw (Histopathology.)Tj /T1_0 1 Tf 0.018 Tw [( 2020;77\(3\):351\226368. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1111/)Tj T* (his.14128)Tj 0 0 0 1 k /GS1 gs 0.072 Tw T* (64.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Dyk)-10(str)-32.9(a MA, )0.5(Gimon TI, )0.5(R)11(onk)-10(sle)-11(y )0.5(PE, )0.5(e)-12(t al. )0.5(Cl)-16(assic )0.5(and )0.5(novel his)]TJ 0 Tw (-)Tj 0.077 Tw -1.796 -1.25 Td [(t)17(op)32(a)15(t)-13(hol)30(o)-15.9(gic r)-37(isk f)16.1(a)-17(c)-16(t)17(or)-10(s for )0.5(l)35(ym)10(ph node me)-11.9(t)15(ast)15(asis in )0.5(T1 col)30(or)-24(ec)-16(t)15(al )]TJ 0.188 Tw T* [(cancer: )0.5(A)]TJ /Span<>> BDC ( )Tj EMC 4.329 0 Td [(sy)-13(stema)15.1(t)-32(ic )0.5(r)-24(ev)-16(iew )0.5(and )0.5(me)-12(t)15(a-anal)35(y)-12.9(sis. )]TJ /T1_1 1 Tf 15.962 0 Td [(Dis )0.5(Colon )0.5(R)21(ectum.)]TJ /T1_0 1 Tf 0 Tw ( )Tj 0.023 Tw -20.291 -1.25 Td [(2021;64:1139\22650. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1097/DCR.0000000000002164)Tj 0 0 0 1 k /GS1 gs 0.034 Tw T* (65.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(W)12(ashing)17(t)17(on )0.6(M, )0.5(Ber)-30(l)-31(in )0.6(J, )0.5(Br)-33(ant)17.1(on )0.5(F, )0.5(e)-12(t )0.6(al. )0.5(P)35(r)-32(o)17(t)17(o)-16(col )0.6(for )0.5(t)-12.9(he)]TJ /Span<>> BDC ( )Tj EMC 23.087 0 Td [(e)-18(x)-11(ami)]TJ 0 Tw (-)Tj 0.117 Tw -24.883 -1.25 Td [(na)15(t)-32(ion of)]TJ /Span<>> BDC ( )Tj EMC [(spec)-24(imens fr)-32(om p)32(a)15(t)-32(ients wi)-23.9(t)-13(h p)24.9(r)-36.9(imar)-24(y car)-32(c)-24(inomas of)]TJ /Span<>> BDC ( )Tj EMC [(t)-13(he )]TJ 0.042 Tw T* [(col)30(on and r)-24(ec)-16(tum. )]TJ /T1_1 1 Tf [(Arch P)18(athol Lab Med)]TJ /T1_0 1 Tf [(. 2009 O)-16(c)-16(t;133\(10\):1539\22651. )]TJ 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.5858/133.10.5139)Tj 0 0 0 1 k /GS1 gs 0.177 Tw -1.847 -1.25 Td (66.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Har)-24(r)-36.9(is EI, L)35(ewin DN, W)12(ang HL, e)-12(t al. L)70(ym)10(phov)-15(ascul)-15.9(ar inv)-15(asion )]TJ 0.147 Tw -1.796 -1.25 Td [(in col)30(or)-24(ec)-16(t)15(al cancer: an)]TJ /Span<>> BDC ( )Tj EMC [(inter)-31.9(obser)-32(ver v)-15(ar)-37(iabil)-30.9(i)-24(t)-10(y stud)17(y. )]TJ /T1_1 1 Tf (Am J Surg )Tj 0 Tw T* [(P)18(athol.)]TJ /T1_0 1 Tf 0.023 Tw [( 2008;32:1816e21. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw [(10.1097/P)25.1(A)35(S.0b013e3181816083)]TJ 0 0 0 1 k /GS1 gs 0.109 Tw T* (67.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Smi)-24(t)-13(h K)20(J, Jones PF, Bur)-24(k)10(e D)20(A, e)-12(t al. L)70(ym)10(pha)15(t)-32(ic vessel distr)-37(ibu)]TJ 0 Tw (-)Tj 0.159 Tw -1.796 -1.25 Td [(t)-32(ion in t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(mucosa and submucosa and po)17(tent)-32(ial im)10(pl)-31(ica)15(t)-32(ions for )]TJ 0.023 Tw T* [(T1 col)30(or)-24(ec)-15.9(t)15(al tumor)-10(s. )]TJ /T1_1 1 Tf (Diseases of)Tj /Span<>> BDC ( )Tj EMC [(the Colon and R)21.1(ectum.)]TJ /T1_0 1 Tf ( 01 Jan 2011, )Tj T* [(54\(1\):35\22640. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1007/dcr.0b013e3181fb0e7a)Tj 0 0 0 1 k /GS1 gs 0.013 Tw T* (68.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Be)-12(tge J, P)10(ollheimer MJ, L)-32(ind)17.1(tner RA, e)-12(t al. Intr)-33(amur)-32.9(al and e)-18(xtr)-32.9(a)]TJ 0 Tw (-)Tj -1.796 -1.25 Td [(mur)-33(al v)-14.9(ascul)-16(ar inv)-15(asion )0.5(in col)30(or)-24(ec)-16(t)15(al )0.5(cancer: p)25(r)-32(o)-16(gnost)-32(ic signif)-27.9(icance )]TJ 0.001 Tc 0.35 Tw T* [(and qual)-31.1(i)-24(t)-10.1(y )0.5(of)]TJ /Span<>> BDC ( )Tj EMC 6.923 0 Td [(p)31.9(a)14.9(t)-13(hol)29.9(o)-16(g)15.9(y )0.5(r)-24.1(epor)-22.1(t)-32(ing. )]TJ /T1_1 1 Tf -0.001 Tw (Cancer)Tj /T1_0 1 Tf 0.35 Tw [(. 2012;118:628\226638.)1( )]TJ 0 Tc 0 Tw -6.923 -1.25 Td [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1002/cncr.26310)Tj 0 0 0 1 k /GS1 gs 0.061 Tw -1.847 -1.25 Td (69.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(R\366nno)-14(w CF, Ar)-22(t)-13(hur)-9.9(sson V, T)45(o)17(t)-13(h E, e)-12(t al. L)70(ym)10(phov)-15(ascul)-15.9(ar inf)-27.9(il)56(tr)-33(a)]TJ 0 Tw (-)Tj 0.003 Tw -1.796 -1.25 Td [(t)-32(ion, no)17.1(t dept)-13(h of)]TJ /Span<>> BDC ( )Tj EMC [(inv)-15(asion, is t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(cr)-37(i)-23.9(t)-32(ical r)-37(isk f)16(a)-17(c)-16(t)17(or of)]TJ /Span<>> BDC ( )Tj EMC [(me)-12(t)15(ast)15(ases in )]TJ 0.005 Tw T* [(ear)-30(l)35(y col)30(or)-24(ec)-16(t)15(al cancer: r)-23.9(e)-12(tr)-32(ospec)-16(t)-32(i)-15.9(ve popul)-16(a)15(t)-32(ion-based cohor)-22(t stud)17(y )]TJ T* [(on p)25(r)-32(ospec)-16(t)-32(i)-16(vel)35.1(y collec)-16(ted d)42(a)15(t)15(a, incl)35(uding v)-14.9(al)-31(id)42(a)15(t)-32(ion. )]TJ /T1_1 1 Tf (Ann Surg.)Tj /T1_0 1 Tf ( Epub )Tj 0.023 Tw T* [(2020; Mar 13. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw [(10.1097/SL)-35(A.0000000000003854)]TJ 0 0 0 1 k /GS1 gs 0.114 Tw T* (70.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Bianchi G, Annicchiar)-36.9(ico A, M)-23.9(or)-37(ini A, e)-12(t al. 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L)35(o)-16(cal)-31(ised col)30(on can)]TJ 0 Tw (-)Tj 0.002 Tc 0.35 Tw -1.796 -1.25 Td [(cer: ESMO Cl)-31.4(inical P)34.6(r)-33.4(a)-17.4(c)-16.3(t)-32.4(ice Guidel)-31.4(ines for dia)-17.4(gnosis, tr)-24.3(ea)14.6(tment)2( )]TJ 0 Tc 0.09 Tw T* [(and foll)30(o)-14(w-up. )]TJ /T1_2 1 Tf (Ann Oncol.)Tj /T1_1 1 Tf [( 2020;31\(10\):1291\2261305. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1016/j.)Tj T* (annonc.2020.06.022)Tj 0 0 0 1 k /GS1 gs 0.008 Tw T* (11.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(P)-24(imentel-Nunes P, L)-32(ibanio D, Bast)-32(iaansen BAJ, e)-12(t al. End)-16(oscopic )]TJ 0.011 Tc 0.395 Tw -1.796 -1.25 Td [(submucosal )0.6(dissec)-15.6(t)-31.6(ion )0.6(for )0.5(s)0.5(uper)-23.6(f)-27.6(ic)-23.6(ial )0.6(gastr)-31.6(ointest)-31.6(inal )0.6(lesions:)11( )]TJ 0 Tc 0.003 Tw T* [(Eur)-32(opean S)-16(o)-16(c)-23.9(ie)-12(t)-10(y of)]TJ /Span<>> BDC ( )Tj EMC [(Gastr)-32(ointest)-31.9(inal End)-16(oscopy \(ESGE\) Guidel)-30.9(ine)]TJ /Span<>> BDC ( )Tj EMC (\227 )Tj 0.019 Tw T* [(U)13(pd)42(a)15(te 2022. )]TJ /T1_2 1 Tf 0 Tw [(Endoscop)12.1(y)]TJ /T1_1 1 Tf 0.019 Tw [(. 2022;\(54\):591\226622. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw 20.528 0 Td (10.1055/a-1811\226)Tj -20.528 -1.25 Td (7025)Tj 0 0 0 1 k /GS1 gs 0.025 Tw T* (12.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Hashiguchi Y, Mur)-32(o K, Sai)-24(t)17(o Y, e)-12(t al. Jap)32(anese S)-16(o)-16(c)-24(ie)-11.9(t)-10(y for Cancer )]TJ 0.06 Tw -1.796 -1.25 Td (of)Tj /Span<>> BDC ( )Tj EMC [(t)-13(he Col)30(on and R)13(ec)-16(tum \(JSCCR\) guidel)-31(ines 2019 for t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(tr)-24(ea)15(tment )]TJ -0.027 Tw T* (of)Tj /Span<>> BDC ( )Tj EMC [(col)30(or)-24(ec)-16(t)15(al cancer. )]TJ /T1_2 1 Tf (Int J Clin Oncol)Tj /T1_1 1 Tf [(. 2020;25\(1\):1\22642. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1007/)Tj T* (s10147-019-01485-z)Tj 0 0 0 1 k /GS1 gs 0.073 Tw T* (13.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Jap)32(anese S)-16(o)-16(c)-24(ie)-12(t)-9.9(y for Cancer of)]TJ /Span<>> BDC ( )Tj EMC [(t)-12.9(he Col)30(on and R)13(ec)-15.9(tum Jap)32.1(anese )]TJ 0.01 Tc 0.373 Tw -1.796 -1.25 Td [(Cl)-16(assif)-28(ica)15(t)-32(ion of)]TJ /Span<>> BDC ( )Tj EMC [(Col)30.1(or)-24(ec)-16(t)15(al, Appendiceal, and Anal Car)-32(c)-24(inoma:)10( )]TJ 0 Tc 0.267 Tw T* [(t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(3r)-24(d Engl)-31(ish Edi)-24(t)-32(ion [Second)42(ar)-24(y P)20(ubl)-31(ica)15(t)-32(ion]. )]TJ /T1_2 1 Tf [(J Anus R)21(ectum )]TJ 0 Tw T* (Colon.)Tj /T1_1 1 Tf 0.023 Tw [( 2019;3:175\226195. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw [(10.23922/jar)-31.9(c.2019-018)]TJ 0 0 0 1 k /GS1 gs 0.054 Tw T* (14.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Benson )0.6(A, )0.5(Al)-16(an )0.6(P, )0.5(V)30(eno)-15.9(ok )0.5(A, )0.6(e)-12(t )0.5(al. )0.6(Col)30(on )0.5(Cancer, )0.6(V)30(er)-10(sion )0.6(2.2021, )]TJ 0.206 Tw -1.796 -1.25 Td [(NCCN Cl)-30.9(inical P)35(r)-33(a)-17(c)-16(t)-32(ice Guidel)-31(ines in Oncol)30.1(o)-16(g)16(y. )]TJ /T1_2 1 Tf [(J N)18(atl Com)16(p)46(r Canc )]TJ 0 Tw T* [(N)18(etw.)]TJ /T1_1 1 Tf 0.023 Tw [( 2021;19\(3\):329\226359. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.6004/jnccn.2021.0012)Tj 0 0 0 1 k /GS1 gs 0.341 Tw T* (15.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Benson )0.5(A, V)30(eno)-16(ok )0.5(AP, Al-Ha)10.1(w)-12(ar)-24(y )0.5(MM, e)-12(t )0.5(al. R)13(ec)-16(t)15(al )0.5(Cancer, )]TJ 0.244 Tw -1.796 -1.25 Td [(V)30(er)-10(sion 2.2022, NCCN Cl)-30.9(inical P)35(r)-33(a)-17(c)-16(t)-32(ice Guidel)-30.9(ines in Oncol)30(o)-16(g)16(y. )]TJ /T1_2 1 Tf 0 Tw (J )Tj 0.152 Tw T* [(N)18(atl Com)16(p)46(r Canc N)18(etw. )]TJ /T1_1 1 Tf [(2022 O)-16(c)-15.9(t;20\(10\):1139\2261167. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.6004/)Tj T* (jnccn.2022.0051)Tj 0 0 0 1 k /GS1 gs 0.271 Tw T* (16.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Y)40(oshi)-16(i S, N)-14(ojima M, N)-14(osho K, e)-12(t al. F)20(a)-17(c)-16(t)17(or)-9.9(s asso)-15.9(c)-24(ia)15(ted wi)-24(t)-13(h )]TJ 0.311 Tw -1.796 -1.25 Td [(r)-37(isk for col)30(or)-24(ec)-16(t)15.1(al cancer r)-23.9(ecur)-24(r)-24(ence af)-28(ter end)-16(oscopic r)-24(esec)-16(t)-32(ion )]TJ 0.008 Tc 0.35 Tw T* (of)Tj /Span<>> BDC ( )Tj EMC [(T1 tumor)-10.3(s. )]TJ /T1_2 1 Tf (Clin Gastroenterol Hepatol.)Tj /T1_1 1 Tf [( 2014;12:292\226302.e3.)8( )]TJ 0 Tc 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1016/j.cgh.2013.08.008)Tj 0 0 0 1 k /GS1 gs 0.139 Tw -1.847 -1.25 Td (17.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Ozek)-16(i T, S)-16(himur)-33(a T, Ozek)-16(i T, e)-12(t al. T)47(he)]TJ /Span<>> BDC ( )Tj EMC [(R)-24(isk Anal)35(y)-13(ses of)]TJ /Span<>> BDC ( )Tj EMC [(L)70(ym)10(ph )]TJ 0.063 Tw -1.796 -1.25 Td [(N)-14(ode )0.6(Me)-12(t)15(ast)15(asis )0.6(and )0.5(R)13(ecur)-23.9(r)-24(ence )0.6(for )0.5(Submucosal )0.6(Inv)-14.9(asi)-16(ve )0.5(Col)30.1(or)-24(ec)-16(t)15(al )]TJ 0.013 Tc 0.463 Tw T* [(Ca)0.5(nc)0.5(er:)0.5( N)-13.5(ove)0.5(l Cr)-36.5(i)-23.6(t)0.5(er)-36.5(ia)0.5( t)17.4(o)]TJ /Span<>> BDC ( )Tj EMC [(S)-15.6(k)-15.5(ip)0.5( Co)0.5(m)10.4(pl)0.5(e)-11.5(t)-31.6(io)0.5(n S)0.5(ur)-31.5(ger)-23.5(y.)0.5( )]TJ /T1_2 1 Tf -0.013 Tw [(C)0.5(anc)0.5(er)0.5(s)]TJ /T1_1 1 Tf 0 Tc 0 Tw (. )Tj 0.023 Tw T* [(2022;14\(3\):822. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw [(10.3390/cancer)-10(s14030822)]TJ 0 0 0 1 k /GS1 gs 0.026 Tw T* (18.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Ichimasa K, K)25(ud)-16(o SE, Miy)22(a)-17(chi H, e)-12(t al. Cur)-24(r)-23.9(ent p)25(r)-32(oblems and per)]TJ 0 Tw 25.49 0 Td (-)Tj -0.005 Tw -27.286 -1.25 Td [(spec)-16(t)-32(i)-15.9(ves of)]TJ /Span<>> BDC ( )Tj EMC [(p)32(a)15(t)-12.9(hol)30(o)-16(gical r)-37(isk f)16(a)-17(c)-16(t)17(or)-9.9(s for l)35(ym)10.1(ph node me)-12(t)15(ast)15.1(asis in T1 )]TJ 0.125 Tw T* [(col)30(or)-24(ec)-15.9(t)15(al cancer: Sy)-13(stema)15.1(t)-32(ic r)-24(ev)-15.9(iew. )]TJ /T1_2 1 Tf (Dig Endosc.)Tj /T1_1 1 Tf ( 2022;34:901\22612. )Tj 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1111/den.14220)Tj 0 0 0 1 k /GS1 gs 0.138 Tw -1.847 -1.25 Td (19.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Z)10(af)-56(f)16(al)30(on D, Da)-17(ca-Al)30.1(v)-15(ar)-24(ez M, Saez de Gor)-24(d)-16(oa K, e)-12(t al. Dilemmas )]TJ 0.003 Tc 0.35 Tw -1.796 -1.25 Td [(in t)-13.2(he)]TJ /Span<>> BDC ( )Tj EMC [(Cl)-31.3(inical Mana)-17.2(gement of)]TJ /Span<>> BDC ( )Tj EMC [(pT1 Col)29.8(or)-24.2(ec)-16.2(t)14.7(al Cancer. )]TJ /T1_2 1 Tf -0.003 Tw (Cancers)Tj /T1_1 1 Tf 0 Tc 0 Tw (. )Tj 0.023 Tw T* [(2023;15:3511. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw [(10.3390/cancer)-10(s15133511)]TJ 0 0 0 1 k /GS1 gs -0.005 Tw T* (20.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Choi YS, Kim WS, Hw)-12(ang S)-10(W, e)-11.9(t al. Cl)-31(inical outcomes of)]TJ /Span<>> BDC ( )Tj EMC (submuco)Tj 0 Tw (-)Tj 0.086 Tw -1.796 -1.25 Td [(sal col)30.1(or)-24(ec)-16(t)15(al cancer dia)-17(gnosed af)-28(ter end)-16(oscopic r)-24(esec)-15.9(t)-32(ion: a)]TJ /Span<>> BDC ( )Tj EMC [(fo)-15.9(cus )]TJ 0.023 Tw T* [(on t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(need for sur)-32(ger)-23.9(y. )]TJ /T1_2 1 Tf [(Intest R)21(es.)]TJ /T1_1 1 Tf ( 2020;18:96\226106.)Tj 0.209 Tw T* (21.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Bea)15(t)17(on C, T)60(wine CP, W)-16(ill)-30.9(iams GL, e)-12(t al.Sy)-13(stema)15(t)-31.9(ic r)-23.9(ev)-16(iew and )]TJ 0.009 Tc 0.351 Tw -1.796 -1.25 Td [(me)-12.3(t)14.7(a-anal)34.6(y)-13.3(sis of)]TJ /Span<>> BDC ( )Tj EMC [(hist)16.7(op)31.7(a)14.6(t)-13.3(hol)29.7(o)-16.4(gical f)15.7(a)-17.4(c)-16.3(t)16.6(or)-10.3(s infl)34.6(uenc)-24.3(ing t)-13.3(he)]TJ /Span<>> BDC ( )Tj EMC [(r)-37.3(isk)9.1( )]TJ 0 Tc 0.122 Tw T* (of)Tj /Span<>> BDC ( )Tj EMC [(l)35(ym)10(ph node me)-12(t)15(ast)15.1(asis in ear)-30(l)35(y col)30(or)-23.9(ec)-16(t)15(al cancer. )]TJ /T1_2 1 Tf (Colorectal Dis.)Tj /T1_1 1 Tf 0 Tw ( )Tj 0.023 Tw 29.055 81.25 Td [(2013 Jul;15\(7\):788\22697. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1111/codi.12129)Tj 0 0 0 1 k /GS1 gs 0.13 Tw T* (22.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Ebbeh\370j A, J\370r)-31.9(gensen L, Kr)-33(ar)-21.9(up P, e)-12(t al. Hist)17.1(op)32(a)15(t)-13(hol)30(o)-16(gical r)-37(isk )]TJ 0.198 Tw -1.796 -1.25 Td [(f)16(a)-17(c)-16(t)17(or)-9.9(s for l)35(ym)10(ph node me)-12(t)15.1(ast)15(ases in T1 col)30(or)-23.9(ec)-16(t)15(al cancer: me)-11.9(t)15(a-)]TJ 0 Tw T* [(anal)35(y)-13(sis. )]TJ /T1_2 1 Tf 3.736 0 Td (BJS)Tj /T1_1 1 Tf 0.023 Tw [(. 2021;108\(7\):769\226776. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1093/bjs/znab168)Tj 0 0 0 1 k /GS1 gs 0.168 Tw -3.736 -1.25 Td (23.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Z)66(w)-12(a)-17(ger )0.5(L)50(W, Bast)-31.9(iaansen BAJ, )0.5(M)-24(ont)15(a)-24(zer)-36.9(i NSM, e)-11.9(t al. Deep )0.5(sub)]TJ 0 Tw (-)Tj 0.115 Tw -1.796 -1.25 Td [(mucosal inv)-14.9(asion is no)17(t an)]TJ /Span<>> BDC ( )Tj EMC [(independent r)-36.9(isk f)16(a)-17(c)-16(t)17(or for l)35(ym)10.1(ph node )]TJ -0.034 Tw T* [(me)-12(t)15(ast)15.1(asis in T1 col)30.1(or)-24(ec)-16(t)15(al cancer: A)]TJ /Span<>> BDC ( )Tj EMC [(me)-12(t)15.1(a-anal)35(y)-13(sis. )]TJ /T1_2 1 Tf 0 Tw (Gastroenterology)Tj /T1_1 1 Tf (. )Tj 0.023 Tw T* [(2022;163:174\22689. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw [(10.1053/j.gastr)-32(o.2022.04.010)]TJ 0 0 0 1 k /GS1 gs 0.01 Tc 0.381 Tw T* (24.)Tj /Span<>> BDC ( )Tj EMC 1.837 0 Td [(S)-16.2(hauk)-17.2(a)14.8(t A, K)-16.2(al)55.8(tenba)-17.2(ch T, Domini)-24.2(tz J)14.8(A, e)-12.2(t al. End)-16.2(oscopic)10( )]TJ 0 Tc 0.237 Tw -1.837 -1.25 Td [(R)13(eco)-16(gni)-24(t)-31.9(ion and )0.5(Mana)-17(gement )0.5(S)15(tr)-32.9(a)15(tegies )0.5(for )0.5(Mal)-31(ignant )0.5(Col)30(or)-23.9(ec)-16(t)15(al )]TJ 0.255 Tw T* [(P)10(ol)35(yps: R)13(ecommend)42(a)15(t)-32(ions of)]TJ /Span<>> BDC ( )Tj EMC [(t)-13(he US Mul)56(t)-32(i-S)-16(o)-16(c)-23.9(ie)-12(t)-10(y T)40(ask F)10(or)-31.9(ce on )]TJ 0.292 Tw T* [(Col)30(or)-23.9(ec)-16(t)15(al Cancer. )]TJ /T1_2 1 Tf (Am J Gastroenterol)Tj /T1_1 1 Tf [(. 2020; N)-14(ov;115\(11\):1751\226)]TJ 0.023 Tw T* [(1767. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.14309/ajg.0000000000001013)Tj 0 0 0 1 k /GS1 gs -0.016 Tw T* (25.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Nak)-17(ad)-16(oi K, T)40(anak)-17(a S, K)-15.9(anao H, e)-12(t al. Mana)-17(gement of)]TJ /Span<>> BDC ( )Tj EMC [(T1 col)30.1(or)-24(ec)-16(t)15(al )]TJ 0.308 Tw -1.796 -1.25 Td [(car)-32(c)-24(inoma wi)-24(t)-13(h spec)-24(ial r)-24(efer)-23.9(ence t)17(o)]TJ /Span<>> BDC ( )Tj EMC [(cr)-37(i)-24(ter)-37(ia for cur)-32.9(a)15(t)-32(i)-16(ve end)-16(o)]TJ 0 Tw (-)Tj 0.01 Tc 0.354 Tw T* [(s)0.5(c)0.6(o)0.5(p)0.5(i)0.6(c)0.5( r)-23.5(e)0.6(s)0.5(e)0.5(c)-15.4(t)-31.5(i)0.6(o)0.5(n)0.6(.)0.5( )]TJ /T1_2 1 Tf [(J)0.6( G)0.6(a)0.5(s)0.6(t)0.5(r)0.5(o)0.6(e)0.5(n)0.6(t)0.5(e)0.6(r)0.5(o)0.6(l)0.5( H)0.6(e)0.5(p)0.5(a)0.6(t)0.5(o)0.6(l)0.5(.)0.6( )]TJ /T1_1 1 Tf -0.01 Tw [(2)0.5(0)0.6(1)0.5(2)0.5(;)0.6(2)0.5(7)0.5(:)0.6(1)0.5(0)0.6(5)0.5(7)0.5(\226)0.6(1)0.5(0)0.5(6)0.6(2)0.5(.)10( )]TJ 0 Tc 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1111/j.1440-1746.2011.07041.x)Tj 0 0 0 1 k /GS1 gs 0.158 Tw -1.847 -1.25 Td (26.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Ba)-17(ck)10(es Y, El)-30.9(ias S, G)20.1(r)-32(oen J, e)-12(t al. Hist)17(ol)30(o)-16(gic f)16(a)-17(c)-16(t)17.1(or)-10(s asso)-16(c)-24(ia)15(ted )]TJ 0.141 Tw -1.796 -1.25 Td [(wi)-24(t)-12.9(h need for )0.5(sur)-32(ger)-24(y )0.5(in p)32(a)15(t)-32(ients )0.5(wi)-24(t)-13(h )0.5(peduncul)-16(a)15(ted )0.5(T1 col)30(or)-24(ec)-16(t)15(al )]TJ 0 Tw T* [(car)-32(c)-24(inomas. )]TJ /T1_2 1 Tf 5.365 0 Td (Gastroenterology)Tj /T1_1 1 Tf 0.257 Tw [(. 2018;154:1647\22659. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1053/j.)Tj -5.365 -1.25 Td [(gastr)-32(o.2018.01.023)]TJ 0 0 0 1 k /GS1 gs 0.033 Tw T* (27.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Aiza)10(w)-12(a D,\300Sugino T, Oishi T, e)-12(t al. T)47(he)]TJ /Span<>> BDC ( )Tj EMC [(essent)-31.9(ial p)25(r)-32(oblem of)]TJ /Span<>> BDC ( )Tj EMC (over-)Tj -0.052 Tw -1.796 -1.25 Td [(measur)-36.9(ing t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(dept)-13(h of)]TJ /Span<>> BDC ( )Tj EMC [(submucosal inv)-15(asion in pT1 col)30(or)-23.9(ec)-16(t)15(al cancer. )]TJ /T1_2 1 Tf 0.023 Tw T* (Virchows Archiv.)Tj /T1_1 1 Tf [( 2021;N)-13.9(ov;05. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1007/s00428-021-03221-3)Tj 0 0 0 1 k /GS1 gs 0.042 Tw T* (28.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Ki)-24(t)15(ajima K, F)10(ujimor)-36.9(i T, F)10(uji)-16(i S, e)-12(t al. 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\017\f\f\035\036\007\024\r\026\027\017\036\ , \022\026\022 \017)Tj /Span<>> BDC ( )Tj EMC (\030\036\031\035\034\021\026\021\t \007\030\031\020\017\b )Tj 0.095 Tw T* (\n\027\024\020\024\004\017\f\035\036\027\027\t\b \030\026\002\024\021, \007\ \036\n\024\027\f\021\030\017\030\031\033\021, \004\021\024 \r)Tj /Span<>> BDC ( )Tj EMC (\027\026\f\021\024)Tj 0 Tw (-)Tj 0.086 Tw T* [(\016\013\036\036 \r\030\036\n\016 \023\030\026\022\021\017\004\036\f\022\ \024\036 \017\f\023\024\035\034\024\r\026\027\017\036 )0.5(\017\031\004\036\027\027\t\b )]TJ 0.158 Tw T* (\023\030\036\007\017\022\021\024\030\024\r \n\036\021\026\f\021\026\017\ \030\024\r\026\027\017\016 \023\024\r\024\035\016\036\021 \007\024\r\024\ \035\034\027\024 )Tj 0.111 Tw 0 -1.218 TD (\021\024\004\027\024 \024\023\030\036\007\036\035\016\021\034 \023\026\006\ \017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\027\017\022\017\n \030\017\f\022\024\n \n\036\021\026)Tj 0 Tw (-)Tj 0.052 Tw 0 -1.218 TD (\f\021\026\017\030\024\r\026\027\017\016, \024\f\027\024\r\t\r\026\016\f\ \034 \017\f\022\035\033\004\017\021\036\035\034\027\024 \027\026)Tj /Span<>> BDC ( )Tj EMC (\024\021\f\031\021)Tj 0 Tw (-)Tj 0.209 Tw T* (\f\021\r\017\017 \027\036\002\035\026\020\024\023\030\017\016\021\027\t\b\ \020\017\f\021\024\035\024\020\017\004\036\f\022\017\b \023\030\017\027\ \026\022\024\r )Tj 0.134 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\024\023\031\b\024\035\017. \203\026)Tj /Span<>> BDC ( )Tj EMC (\f\036\020\024\007\027\016\001\027\017\005 \007\036\027\034 \023\024\023\ \t\021\022\017 \f\024\007\026\027\017\016 )Tj T* (\023\030\024\020\027\024\f\021\017\004\036\f\022\017\b \n\024\007\036\035\ \036\005 \007\035\016 \002\024\035\036\036 \021\024\004\027\024\005 \f\021\ \030\026\021\017)Tj 0 Tw (-)Tj -0.064 Tw T* (\235\017\022\026\006\017\017 \023\026\006\017\036\027\021\024\r \024\021\ \027\024\f\017\021\036\035\034\027\024 \030\017\f\022\026 \n\036\021\026\ \f\021\026\017\030\024)Tj 0 Tw (-)Tj 0.047 Tw 0 -1.218 TD (\r\026\027\017\016 \023\030\024\r\036\007\036\027\t \r)Tj /Span<>> BDC ( )Tj EMC (\030\016\007\036 \017\f\f\035\036\007\024\r\026\027\017\005 \017, \023\024\ )Tj /Span<>> BDC ( )Tj EMC (\n\027\036\027\017\033 )Tj 0.242 Tw 0 -1.218 TD (\026\r\021\024\030\024\r, \017\n\036\027\027\024 \021\026\022\024\005 \023\ \031\021\034 \024\021\002\024\030\026 \023\026\006\017\036\027\021\024\r\ \007\035\016 )Tj 0.245 Tw 0 -1.218 TD (\007\024\023\024\035\027\017\021\036\035\034\027\024\020\024 \b\017\030\031\ \030\020\017\004\036\f\022\024\020\024 \035\036\004\036\027\017\016 \016\ \r\035\016\036\021\f\016 )Tj 0.065 Tw T* [(\027\026\017\002\024\035\036\036 )0.6(\023\036\030\f\023\036\022\021\017\r\027\t\n )0.6([43,78\22680,82,83]. )0.5(\217\026\r\017\021\017\036 )]TJ 0.08 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC 0.83 0 Td [(\023\030\017\n\036\027\036\027\017\036 )0.6(\006\017\235\030\024\r\024\005 )0.5(\023\026\021\024\035\024\020\017\017 )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC 15.212 0 Td (\022\024\n\023\034\033\021\036\030\027\t\b )Tj 0.286 Tw -16.042 -1.218 Td (\021\036\b\027\024\035\024\020\017\005 \023\024\r\024\035\016\021 \024\002\ \255\036\022\021\017\r\017\017\030\024\r\026\021\034 \n\024\030\235\024\ \n\036)Tj 0 Tw (-)Tj 0.092 Tw T* [(\021\030\017\004\036\f\022\017\036 )0.5(\017\n\036\030\036\027\017\016 )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC 10.164 0 Td [(\023\024\007\f\004\036\021 )0.5(\022\024\035\017\004\036\f\021\r\036\027\027\t\b )0.6(\023\026)]TJ 0 Tw (-)Tj 0.231 Tw -10.164 -1.218 Td (\030\026\n\036\021\030\024\r. \236\f\023\024\035\034\024\r\026\027\017\036\ \007\024\023\024\035\027\017\021\036\035\034\027\t\b \n\036\021\024\007\ \017\022 )Tj -0.063 Tw T* (\024\022\030\026\001\017\r\026\027\017\016 \021\026\022\032\036 \030\026\ \f\f\n\026\021\030\017\r\026\036\021\f\016 \022\026\022 \024\007\017\027\ \017)Tj /Span<>> BDC ( )Tj EMC (\f\023\024)Tj 0 Tw (-)Tj 0.158 Tw T* (\f\024\002\024\r \023\024\r\t\001\036\027\017\016 \021\024\004\027\024\f\ \021\017 \024\023\030\036\007\036\035\036\027\017\016 \024\021\007\036\035\ \034\027\t\b )Tj 0.087 Tw T* (\020\017\f\021\024\035\024\020\017\004\036\f\022\017\b \023\030\017\027\ \026\022\024\r, \r)Tj /Span<>> BDC ( )Tj EMC (\004\026\f\021\027\024\f\021\017, \f\024\f\031\007\017\f\021\024\005 )Tj 0.008 Tw T* (\017\027\r\026\017\017 \017)Tj /Span<>> BDC ( )Tj EMC (\024\023\031\b\024\035\036\r\024\020\024 \002\026\007\007\017\027\020\026\ , \017)Tj /Span<>> BDC ( )Tj EMC (\022\026\022 \007\036\005\f\021\r\036\027\027\024\020\024 )Tj 0.251 Tw T* (\f\023\024\f\024\002\026 \031\035\031\004\001\036\027\017\016 \017\b \r\024\ \f\023\030\024\017\r\024\007\017\n\024\f\021\034 [78,81]. )Tj 0.023 Tw T* (\025\030\024\n\036 \021\024\020\024, \024\023\030\036\007\036\035\036\027\ \027\t\036 \023\036\030\f\023\036\022\021\017\r\t \r)Tj /Span<>> BDC ( )Tj EMC (\031\035\031\004\001\036\027\017\017 )Tj 0.239 Tw T* (\024\006\036\027\022\017 \235\026\022\021\024\030\024\r \030\017\f\022\026\ \n\036\021\026\f\021\026\017\030\024\r\026\027\017\016 \024\023\031\b\024\ \035\017 )Tj 0.041 Tw T* (\f\r\016\t\r\026\033\021 \f)Tj /Span<>> BDC ( )Tj EMC (\023\030\017\n\036\027\036\027\017\036\n \017\f\022\031\f\f\021\r\036\027\ \027\024\020\024 \017\027\021\036\035\035\036\022)Tj 0 Tw (-)Tj T* (\021\026 [84,85].)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 70.936 347.3118 Tm [(\020)21(\026\027\r\241\224\034\022\031\034)]TJ 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0 Tc 0.205 Tw 10 0 0 10 70.8661 322.9558 Tm (\236\f\b\024\007\016 \017)Tj /Span<>> BDC ( )Tj EMC (\030\036\031\035\034\021\026\021\024\r \023\030\024\r\036\007\036\027\027\ \t\b \017\f\f\035\036\007\024\r\026\027\017\005, )Tj 0.209 Tw T* (\f\035\036\007\031\036\021 \022\024\027\f\021\026\021\017\030\024\r\026\021\ \034 \027\026\035\017\004\017\036 \027\026\004\017\021\036\035\034\027\024\ \020\024 \022\024)Tj 0 Tw (-)Tj 0.331 Tw T* (\035\017\004\036\f\021\r\026 \024\020\030\026\027\017\004\036\027\017\005\ \r)Tj /Span<>> BDC ( )Tj EMC (\017\f\023\024\035\034\024\r\026\027\017\017 \n\024\030\235\024\035\024\ )Tj 0 Tw (-)Tj 0.126 Tw T* (\020\017\004\036\f\022\017\b \023\030\036\007\017\022\021\024\030\024\r \ \017)Tj /Span<>> BDC ( )Tj EMC (\027\036\024\002\b\024\007\017\n\024\f\021\034 \023\030\024\r\036\007\036\ \027\017\036 )Tj 0.464 Tw T* [(\007\024\023\024\035\027\017\021\036\035\034\027\t\b )0.5(\017\f\f\035\036\007\024\r\026\027\017\005 \007\035\016 \031\021\024\004\ \027\036\027\017\016 )0.5(\017\b )]TJ 0.365 Tw T* (\023\030\024\020\027\024\f\021\017\004\036\f\022\024\020\024 \027\026\004\ \036\027\017\016 \017)Tj /Span<>> BDC ( )Tj EMC (\031\027\017\235\017\022\026\006\017\017 \f\017\f\021\036\n )Tj 0.111 Tw T* (\024\006\036\027\022\017. \200\027\036\007\030\036\027\017\036 \f\022\030\ \017\027\017\027\020\024\r\t\b \023\030\024\020\030\026\n\n \007\017\022\ \021\031\036\021 )Tj 0.388 Tw T* (\027\036\024\002\b\024\007\017\n\024\f\021\034 \031\035\031\004\001\036\027\ \017\016 \022\026\004\036\f\021\r\026 \n\024\030\235\024\035\024\020\017\ \004\036)Tj 0 Tw (-)Tj 0.117 Tw T* (\f\022\024\005 \007\017\026\020\027\024\f\021\017\022\017 \030\026\027\027\ \036\020\024 \025\217\217 \023\031\021\036\n \f\024\007\026\027\017\016\ \036\007\017)Tj 0 Tw (-)Tj 0.103 Tw T* (\027\t\b \022\030\017\021\036\030\017\036\r \024\006\036\027\022\017 \n\024\ \030\235\024\035\024\020\017\004\036\f\022\017\b \023\030\017\027\026\022\ \024\r, )Tj -0.042 Tw T* [(\031\035\031\004\001\036\027\017\016 \017\b \r\024\f\023\030\024\017\r\024\ \007\017\n\024\f\021\017 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC (\007\024\023\024\035\027\017\021\036\035\034\027\024\020\024 )Tj 0.079 Tw 23.244 52.365 Td (\024\002\031\004\036\027\017\016 \023\026\021\024\035\024\020\024\r, \031\ \004\017\021\t\r\026\016 \027\026\004\036\027\017\036 \n\024\030\235\024\ \035\024\020\017)Tj 0 Tw (-)Tj 0.199 Tw 0 -1.218 TD (\004\036\f\022\017\b \b\026\030\026\022\021\036\030\017\f\021\017\022 \024\ \023\031\b\024\035\017 \007\035\016 \023\030\017\027\016\021\017\016 \030\ \036\001\036)Tj 0 Tw (-)Tj 0.134 Tw 0 -1.218 TD (\027\017\016 \024)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\021\017\022\036 \035\036\004\036\027\017\016 \023\026\006\017\ \036\027\021\024\r \023\024\f\035\036 \035\024\022\026\035\034\027\024\020\ \024 )Tj 0.169 Tw 0 -1.218 TD (\031\007\026\035\036\027\017\016 \2301 \025\217\217. \224\035\036\007\031\ \036\021 \024\021\n\036\021\017\021\034, \004\021\024 \r)Tj /Span<>> BDC ( )Tj EMC (\022\035\017\027\017\004\036)Tj 0 Tw (-)Tj 0.262 Tw 0 -1.218 TD (\f\022\024\005 \023\030\026\022\021\017\022\036 \022\030\017\021\017\004\ \036\f\022\024\036 \027\026\004\036\027\017\036 \n\024\032\036\021 \017\ \n\036\021\034 )Tj 0.452 Tw 0 -1.218 TD (\027\036 \021\024\035\034\022\024 \253\027\036\007\024\024\006\036\027\022\ \026\273 \027\036\002\035\026\020\024\023\030\017\016\021\027\t\b \020\017\ \f\021\024)Tj 0 Tw (-)Tj 0.319 Tw 0 -1.218 TD (\035\024\020\017\004\036\f\022\017\b \023\030\017\027\026\022\024\r, \027\ \024 \017)Tj /Span<>> BDC ( )Tj EMC (\017\b \020\017\023\036\030\007\017\026\020\027\024\f\021\017\022\026, )Tj 0.214 Tw 0 -1.218 TD (\022\024\021\024\030\026\016 \n\024\032\036\021 \023\030\017\r\036\f\021\ \017 \022)Tj /Span<>> BDC ( )Tj EMC (\023\030\036\r\t\001\036\027\017\033 \023\024\022\026\026\027\017\005 )Tj 0.121 Tw T* (\022)Tj /Span<>> BDC ( )Tj EMC (\b\017\030\031\030\020\017\004\036\f\022\024\n\031 \035\036\004\036\027\017\ \033, \f\r\016\026\027\027\024\n\031 \f)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\036\036 \r\t)Tj 0 Tw (-)Tj -0.003 Tw T* [(\f\024\022\017\n\017 )0.5(\030\017\f\022\026\n\017 )0.5(\035\036\021\026\035\034\027\024\f\021\017 )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC 12.957 0 Td [(\024\f\035\024\032\027\036\027\017\005, )0.6(\027\036\002\035\026\020\024)]TJ 0 Tw (-)Tj 0.351 Tw -12.957 -1.218 Td (\023\030\017\016\021\027\t\b \235\031\027\022\006\017\024\027\026\035\034\ \027\t\b \023\024\f\035\036\007\f\021\r\017\005. \224\024\007\026\027\017\ \036 )Tj 0.052 Tw T* [(\023\030\024\020\027\024\f\021\017\004\036\f\022\017\b )0.6(\n\024\007\036\035\036\005, )0.5(\r\022\035\033\004\026\033\013\017\b )0.6(\022\024\n\002\017\027\026\006\017\033 )]TJ 0.458 Tw T* (\030\026\035\017\004\027\t\b \023\026\030\026\n\036\021\030\024\r \(\022\ \035\017\027\017\004\036\f\022\017\b, \n\024\030\235\024\035\024\020\017\ )Tj 0 Tw (-)Tj 0.143 Tw T* (\004\036\f\022\017\b \017)Tj /Span<>> BDC ( )Tj EMC (\023\030.\) \023\024\r\024\035\017\021 \n\026\022\f\017\n\026\035\034\027\ \024 \021\024\004\027\024 \024\006\036\027\017\021\034 )Tj 0.187 Tw T* (\030\017\f\022 \n\036\021\026\f\021\026\017\030\024\r\026\027\017\016 \017\ )Tj /Span<>> BDC ( )Tj EMC (\024\023\030\036\007\036\035\017\021\034 \017\027\007\017\r\017\007\031\026\ \035\034)Tj 0 Tw (-)Tj 0.217 Tw T* (\027\t\036 \023\024\022\026\026\027\017\016 \022)Tj /Span<>> BDC ( )Tj EMC (\007\024\023\024\035\027\017\021\036\035\034\027\024\n\031 \b\017\030\031\ \030\020\017\004\036\f\022\024\n\031 )Tj -0.013 Tw T* (\035\036\004\036\027\017\033 \023\024\f\035\036 \220\027\007\024\f\022\024\ \023\017\004\036\f\022\024\020\024 \031\007\026\035\036\027\017\016 \024\ \023\031\b\024\035\036\005 )Tj 0.064 Tw T* [(\2301. )0.5(\224\021\026\027\007\026\030\021\017\026\006\017\016 )0.5(\n\024\030\235\024\035\024\020\017\004\036\f\022\017\b )0.6(\017\f\f\035\036\007\024\r\026\027\017\005, )]TJ 0.269 Tw T* (\017\b \024\002\255\036\022\021\017\r\017\026\006\017\016 \f)Tj /Span<>> BDC ( )Tj EMC [(\023\030\017\r\035\036\004\036\027\017\036\n )0.5(\022\024\n\023\034\033\021\036\030\027\t\b )]TJ 0.089 Tw T* [(\021\036\b\027\024\035\024\020\017\005 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC [(\017\f\022\031\f\f\021\r\036\027\027\024\020\024 )0.5(\017\027\021\036\035\035\036\022\021\026)]TJ /Span<>> BDC ( )Tj EMC 17.532 0 Td [(\227 \220\021\024 )0.5(\036\013\036 )]TJ 0.027 Tw -17.532 -1.218 Td (\024\007\017\027 \r\024\n\024\032\027\t\005 \023\031\021\034, \023\030\036\ \007\035\026\020\026\036\n\t\005 \017\f\f\035\036\007\024\r\026\021\036\035\ \016)Tj 0 Tw (-)Tj -0.048 Tw T* (\n\017 \007\035\016 \023\024\r\t\001\036\027\017\016 \022\026\004\036\f\021\ \r\026 \017)Tj /Span<>> BDC ( )Tj EMC (\021\024\004\027\024\f\021\017 \023\026\021\024\n\024\030\235\024\035\024\ )Tj 0 Tw (-)Tj 0.122 Tw T* (\020\017\004\036\f\022\017\b \017\f\f\035\036\007\024\r\026\027\017\005 \ \017)Tj /Span<>> BDC ( )Tj EMC (\024\023\030\036\007\036\035\036\027\017\016 \023\030\036\007\017\022\021\ \024\030\024\r )Tj 0.105 Tw T* (\n\036\021\026\f\021\026\017\030\024\r\026\027\017\016 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\022\024\035\024\030\036\022\021\026\035\034\027\024\n \030\026\022\036 \ \f)Tj /Span<>> BDC ( )Tj EMC (\017\027\r\026)Tj 0 Tw (-)Tj T* (\017\036\005, \024\020\030\026\027\017\004\036\027\027\024\005 \023\024\ \007\f\035\017\017\f\021\024\005 \024\f\027\024\r\024\005 \(\2301\).)Tj /T1_2 1 Tf 0.023 Tw 0 -2.436 TD (\224\030\032\255\020\034\036 \032\026\020\017\022\017\026)Tj /T1_0 1 Tf 0 Tw 0 -1.218 TD [(\025)-4.1(\024)-4.3(\027)1.7(\006)-6(\036)-6.8(\023)2.2(\006)-6(\017)-5.4(\016 \017)]TJ /Span<>> BDC ( )Tj EMC [(\007)-5.9(\017)2.7()-9.9(\026\005)1.7(\027 \017)-2.3(\f)3.1(\f)-38.9(\035)-6.8(\036)-19(\007)-4.4(\024)-4.3(\r)-8.9(\026\027)1.7(\017)-5.5(\016)13.7(:)]TJ /T1_3 1 Tf -0.004 Tc 0.004 Tw [( \214)6.2(\037\004)3.2(\020\034)5.6(\036)-5.3(\024\021)8.7(\037)-1.9(\030)]TJ /Span<>> BDC 19.925 0 Td ( )Tj EMC [(\240)23.6(.)3.3(\205)-6.2(.)]TJ /T1_0 1 Tf 0 Tc 0 Tw -19.925 -1.218 Td [(\224)-4.6(\002)-9.9(\024)0.7(\030 \017)]TJ /Span<>> BDC ( )Tj EMC [(\024)-11.8(\002)3(\030)-11.3(\026)-6.4(\002)-9.9(\024)-10.8(\021)-17.7(\022)-19.1(\026 \n)1.3(\026)-11.8(\021)-9.9(\036)-1.7(\030)-7.6(\017)-0.6(\026)-33.1(\035)-2.5(\024)-4.3(\r)10.4(:)]TJ /T1_3 1 Tf -0.004 Tc 0.004 Tw [( \214)6.2(\037)0.5(\004)3.2(\020\034)5.6(\036)-5.3(\024\021)8.7(\037)-1.8(\030)]TJ /Span<>> BDC 17.796 0 Td ( )Tj EMC [(\240)23.6(.)3.3(\205)-6.3(.)]TJ /T1_0 1 Tf 0.002 Tc -0.002 Tw -17.796 -1.218 Td [(\203)7.2(\026\023)4.2(\017\f)-10.8(\026)1.7(\027)3.7(\017)-6.7(\036)2.1( \021)-7.9(\036)-3.4(\022\f)-34(\021)-19.5(\026)5.7(:)]TJ /T1_3 1 Tf -0.004 Tc 0.004 Tw 7.694 0 Td [( \214)6.2(\037\004)3.2(\020\034)5.7(\036)-5.3(\024\021)8.7(\037)-1.9(\030)]TJ /Span<>> BDC 5.056 0 Td ( )Tj EMC [(\240)23.6(.)3.3(\205)-6.3(.)]TJ /T1_0 1 Tf 0 Tc 0 Tw -12.75 -1.218 Td [(\217)5.5(\036)-19(\007)-20.1(\026\022)-32.6(\021)-17.7(\017)1.4(\030)-11.8(\024)-4.2(\r)-9(\026\027)1.8(\017)-8.7(\036)6.5(:)]TJ /T1_3 1 Tf -0.004 Tc 0.004 Tw [( \214)6.2(\037\004)3.2(\020\034)5.7(\036)-5.3(\024\021)8.7(\037)-1.9(\030)]TJ /Span<>> BDC 12.191 0 Td ( )Tj EMC [(\240)23.6(.)3.3(\205)-6.3(.)]TJ /T1_2 1 Tf 0 Tc 0.023 Tw -12.191 -2.436 Td (AUTHORS CONTRIBUTION)Tj /T1_0 1 Tf 0 Tw T* [(C)-6.5(o)0.8(nce)-0.7(p)-12.3(t a)2.4(n)-4.6(d d)-5.4(e)-13.3(s)-16.6(i)3.2(g)1.2(n o)-2.2(f)]TJ /Span<>> BDC ( )Tj EMC [(t)-16.7(h)-5.3(e s)-19.9(t)-12.8(ud)-10.9(y)-11.8(:)]TJ /T1_3 1 Tf [( O)-7.4(l)4.7(ga)]TJ /Span<>> BDC ( )Tj EMC [(A)-12.5(.)]TJ /Span<>> BDC ( )Tj EMC [(M)5.2(a)-2(i)8.4(n)1.9(o)-0.6(v)-3.9(s)9.1(k)15.9(a)-5.9(y)3.8(a)]TJ /T1_0 1 Tf 1.665 Tw T* [(C)-6.5(o)-5.8(l)-19(l)-14.3(e)-9.4(c)-32.5(t)-37.3(i)3.2(o)0.8(n a)2.4(n)-4.6(d p)-3.8(r)-6(o)-6.9(ce)-13.2(s)-12.8(s)-16.6(i)7.1(n)-1.9(g o)-2.2(f)]TJ /Span<>> BDC ( )Tj EMC [(m)1.8(a)-8.4(t)-15.2(e)-2.1(r)-48(i)5.1(a)-1.5(l)-22.5(:)]TJ /T1_3 1 Tf 0 Tw ( )Tj T* [(O)-7.4(l)4.7(ga)]TJ /Span<>> BDC ( )Tj EMC [(A)-12.6(.)]TJ /Span<>> BDC ( )Tj EMC [(M)5.2(a)-2(i)8.4(n)1.9(o)-0.6(v)-3.9(s)9.1(k)15.8(a)-5.9(y)3.9(a)]TJ /T1_0 1 Tf -0.052 Tc 0.052 Tw T* [(Te)-75.9(x)-88(t)-52( w)-73(r)-99.9(i)-58(t)-89.4(i)-44.9(n)-53.9(g)-43(:)]TJ /T1_3 1 Tf 0 Tc 0 Tw 5.233 0 Td [( O)-7.4(l)4.7(ga)]TJ /Span<>> BDC ( )Tj EMC [(A)-12.5(.)]TJ /Span<>> BDC ( )Tj EMC [(M)5.2(a)-2(i)8.4(n)1.9(o)-0.6(v)-3.9(s)9.1(k)15.9(a)-5.9(y)3.8(a)]TJ /T1_0 1 Tf 0.006 Tc -0.006 Tw -5.233 -1.218 Td [(E)11.6(dit)-31.4(i)13.1(n)4.1(g)15(:)]TJ /T1_3 1 Tf 0 Tc 0 Tw 3.238 0 Td [( O)-7.4(l)4.7(ga)]TJ /Span<>> BDC ( )Tj EMC [(A)-12.5(.)]TJ /Span<>> BDC ( )Tj EMC [(M)5.2(a)-2(i)8.4(n)1.9(o)-0.6(v)-3.9(s)9.1(k)15.9(a)-5.9(y)3.8(a)]TJ /T1_2 1 Tf 0.023 Tw -3.238 -2.436 Td (\255\026\036\031\036\025\034\226 \017\223 \032\026\020\017\022\032\225 \(\ ORCID\))Tj /T1_0 1 Tf 0 Tw T* (\204\026\005\027\024\r\f\022\026\016 \210.\202.)Tj /Span<>> BDC ( )Tj EMC (\227 0000-0001-8189-3071)Tj /T1_2 1 Tf 0.023 Tw 0 -2.436 TD (INFORMATION ABOUT THE)Tj /Span<>> BDC ( )Tj EMC (AUTHORS \(ORCID\))Tj /T1_0 1 Tf 0 Tw 0 -1.218 TD [(Ol)16(ga A. Mainovsk)-16.9(a)15(y)22(a)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0001-8189-3071)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 70.936 164.6418 Tm [(\r\031\024\034\033)48(\026)45(\024)-10(\223\033)48(\026/REFERENCES)]TJ 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0 Tc 0.038 Tw 8 0 0 8 70.8661 151.8073 Tm (1.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(\025\026\023\030\017\027 \202.\212., )0.5(\224\021\026\030\017\027\f\022\017\005 )0.5(\200.\200., \221\026\b\026\007\024\r\026 \210.\202. )0.5(\224\024\f\021\024\016\027\017\036 \024\027\022\024)]TJ 0 Tw (-)Tj 0.178 Tw -1.296 -1.25 Td (\035\024\020\017\004\036\f\022\024\005 \023\024\n\024\013\017 \027\026\f\ \036\035\036\027\017\033 \217\024\f\f\017\017 \r)Tj /Span<>> BDC ( )Tj EMC (2020 \020\024\007\031. \204.: \204\203\236\210\236 )Tj 0.003 Tw 0 -1.25 TD (\017\n. \215.\202. \206\036\030\006\036\027\026 \235\017\035\017\026\035\ \205\206\207\211 \253\203\204\236\217\037\273 \204\017\027\007\030\026\ \r\026 \217\024\f\f\017\017; 2021. )Tj 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.924 0 Td (10.1017/CBO9781107415324.004)Tj 0 0 0 1 k /GS1 gs 0.101 Tw [( )0.5(/ )0.5(K)-16(ap)25(r)-36.9(in )0.5(A.D., )0.5(S)15(t)15(ar)-37(insk)-32(y)]TJ /Span<>> BDC ( )Tj EMC 23.936 0 Td (V.V., )Tj 0.272 Tw -25.861 -1.25 Td [(S)-16(hakhzad)-15.9(ov)-15(a O.A. T)47(he)]TJ /Span<>> BDC ( )Tj EMC [(st)15.1(a)15(te of)]TJ /Span<>> BDC ( )Tj EMC [(oncol)30(o)-16(gical car)-24(e for t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(popul)-16(a)]TJ 0 Tw (-)Tj 0.093 Tw T* [(t)-32(ion of)]TJ /Span<>> BDC ( )Tj EMC [(Russia in 2020. M)-24(osco)-13.9(w: P.A. Her)-24(zen M)-23.9(osco)-14(w S)15(t)15(a)15(te Medical )]TJ -0.007 Tw T* [(R)13(esear)-32(ch Inst)-32(i)-24(tute br)-33(anch of)]TJ /Span<>> BDC ( )Tj EMC [(t)-13(he F)10(eder)-33(al S)15(t)15(a)15(te Budge)-12(t)15(ar)-24(y Inst)-32(i)-24(tut)-31.9(ion )]TJ 0.305 Tw T* (\237NMIRC\241 of)Tj /Span<>> BDC ( )Tj EMC [(t)-13(he Ministr)-23.9(y of)]TJ /Span<>> BDC ( )Tj EMC [(Heal)56(t)-13(h of)]TJ /Span<>> BDC ( )Tj EMC (Russia; 2021. \(in Russ.\). )Tj 0 Tw 29.055 8.75 Td [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1017/CBO9781107415324.004)Tj 0 0 0 1 k /GS1 gs -0.018 Tw -1.847 -1.25 Td (2.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(\200\210\003. \025\024\035\024\030\036\022\021\026\035\034\027\t\005 \030\ \026\022. 2023. / WHO. Col)30(or)-24(ec)-16(t)15(al Cancer. 2023. )]TJ 0.127 Tw -1.296 -1.25 Td [(\(in Russ.\). ht)-30(tps://www.who.int/r)-21.8(u/news-r)-32(o)-16(om/f)16.1(a)-17(c)-16(t-shee)-12(ts/de)-11.9(t)15(ail/)]TJ 0 Tw T* [(col)30(or)-24(ec)-15.9(t)15(al-cancer#)]TJ 0.2 Tw T* (3.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(T)40(a)15(yl)30(or EF, M)-24(or)-23.9(r)-37(is EJ)15(A, T)47(homas JD, e)-12(t al. Major im)10(p)25(r)-32(ovement in )]TJ 0.202 Tw -1.296 -1.25 Td [(t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(st)15(a)-17(ge p)25(r)-32(of)-28(ile of)]TJ /Span<>> BDC ( )Tj EMC [(tumour)-10(s dia)-17(gnosed in t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(NHS bo)-14(wel cancer )]TJ 0.023 Tw T* [(scr)-24(eening p)25(r)-32(o)-16(gr)-33(amme. )]TJ /T1_3 1 Tf 0 Tw (Gut)Tj /T1_0 1 Tf 0.023 Tw (. 2010;59\(A31\).)Tj 0.184 Tw T* (4.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(L)35(o)-16(gan RF)24(A, P)40(a)15(tnick J, Nick)10(er)-10(son C, e)-12(t al. Engl)-30.9(ish Bo)-14(wel Cancer )]TJ 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 0 Tw 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\206)10(\002\036\033 \035\030\032\003\033)30(\n)42(\032)-21(\230\033\241)]TJ 57.136 0 Td (REVIEW)Tj -57.136 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 2)69(4, \023\0224, 202)23(5)]TJ 43.013 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 2)69(4, \023\0224, 202)23(5)]TJ /T1_5 1 Tf 25 0 0 25 20.8778 56.0378 Tm (184)Tj ET endstream endobj 1102 0 obj <>/Border[0 0 0]/H/N/Rect[86.262 129.103 195.094 119.807]/Subtype/Link/Type/Annot>> endobj 1103 0 obj <>/Border[0 0 0]/H/N/Rect[318.085 159.103 426.917 149.807]/Subtype/Link/Type/Annot>> endobj 1105 0 obj <> endobj 1104 0 obj <> endobj 1011 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\034\201\025\235\t\016\024\220 \021\022\222\016\201\b\222\016\017)-9.9(\026\021\r\220 \222\201\021\024\016\215\016\215\021\004 \024\025\201\223\ \025\t\025\202\021\f\016\b\017\021 )]TJ 0 -1 TD [(\223\001\017)-10(\026)11(\025\201\025\r \201\021\b\017\001 \024\016\026)11(\001\b)-10(\026)11(\001\213\021\201\025\r\001\215\021\004 \r\022\t\021\024\223\001\026\021\f\ \016\b\017\021\016 \200)31(\213\t\220 )]TJ T* [(\222\201\021\022\017)10(\025\t\025\201\016\017)-10(\026)11(\001\t\214\215\025\024 \201\001\017\016 \0321 \(\025\235\213\025\201 \t\021\ \026)11(\016\201\001\026)-20(\200\201\220\))]TJ 37.237 2 Td [(Pr)20(oblems and pr)20(ospects of\022using morph)11(ological risk factor)20.1(s )]TJ 0.243 -1 Td [(for\022lymph node metastasis in T1 color)31(ectal cancer \(r)31(e)11(vie)11(w\))]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0.443 Tw 10 0 0 10 42.5197 724.8299 Tm (\017\027\r\026\017\017 \031\r\036\035\017\004\017\r\026\036\021 \022\024\ \220\235\235\017\006\017\036\027\021 \022\026\023\023\026 \f)Tj /Span<>> BDC ( )Tj EMC (0,37 )Tj 0.425 Tw 0 -1.218 TD (\(95% CI 0,22\2260,52\) \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\024\022\030\026\f\022\036 \020\036\n\026\021\024\022\f\017\035\017\027\024\ \n )Tj 0.082 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC [(\220\024\017\027\024\n )0.5(\007\024)]TJ /Span<>> BDC ( )Tj EMC (0,62 \(95% CI 0,04\2260,99\))Tj /Span<>> BDC ( )Tj EMC (\227 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\007\024\023\024\035)Tj 0 Tw (-)Tj 0.097 Tw T* (\027\017\021\036\035\034\027\024\005 \024\022\030\026\f\022\036 D2-40. \210\ \007\027\026\022\024 \024\021\f\031\021\f\021\r\017\036 \004\036\021\022\ \017\b )Tj 0.172 Tw T* (\022\030\017\021\036\030\017\036\r \r)Tj /Span<>> BDC ( )Tj EMC (\024\023\030\036\007\036\035\036\027\017\017 \035\017\n\235\024\r\026\f\022\ \031\035\016\030\027\024\005 \017\027\r\026)Tj 0 Tw (-)Tj 0.14 Tw T* (\017\017, \021\036\030\n\017\027\024\035\024\020\017\017 \017)Tj /Span<>> BDC ( )Tj EMC (\n\036\021\024\007\017\022\017 \024\023\030\036\007\036\035\036\027\017\016\ \030\026\027\t\b )Tj 0.081 Tw 0 -1.218 TD (\r\017\007\024\r \f\024\f\031\007\017\f\021\024\005 \017\027\r\026\017\017\ \023\030\017\r\024\007\016\021 \022)Tj /Span<>> BDC ( )Tj EMC (\027\026\004\017\021\036\035\034\027\024\005 )Tj 0.074 Tw 0 -1.218 TD (\r\026\030\017\026\002\036\035\034\027\024\f\021\017 \030\036\031\035\034\ \021\026\021\024\r \r)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\r\024\007\017\n\t\b \017\f\f\035\036\007\024)Tj 0 Tw (-)Tj 0.085 Tw T* (\r\026\027\017\016\b \017)Tj /Span<>> BDC ( )Tj EMC (\023\024\022\026\026\021\036\035\036\005 \024\023\030\036\007\036\035\036\ \027\017\016 \007\026\027\027\024\020\024 \023\030\017\027\026)Tj 0 Tw (-)Tj 0.084 Tw T* (\022\026 \027\026)Tj /Span<>> BDC ( )Tj EMC (\023\030\026\022\021\017\022\036. \215\024)Tj /Span<>> BDC ( )Tj EMC (\007\026\027\027\t\n \026\031\007\017\021\026 20 \023\026\021\024\n\024\030\ \235\024\035\024)Tj 0 Tw (-)Tj 0.219 Tw T* (\020\017\004\036\f\022\017\b \035\026\002\024\030\026\021\024\030\017\005\ , \031\004\026\f\021\r\031\033\013\017\b \r)Tj /Span<>> BDC ( )Tj EMC [(Dutch bo)-14(wel )]TJ 0.076 Tw T* [(scr)-24(eening )0.6(p)24.9(r)-31.9(o)-16(gr)-33(amme )0.5([75], )0.5(\030\026\f\b\024\032\007\036\027\017\016 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 17.884 0 Td (\024\023\030\036\007\036\035\036)Tj 0 Tw (-)Tj 0.216 Tw -17.884 -1.218 Td (\027\017\017 \035\017\n\235\024\r\026\f\022\031\035\016\030\027\024\005 \ \017\027\r\026\017\017 \024\021\n\036\004\036\027\t \r)Tj /Span<>> BDC ( )Tj EMC (31,5% )Tj 0.08 Tw 0 -1.218 TD (\f\035\031\004\026\036\r \017)Tj /Span<>> BDC ( )Tj EMC (\002\t\035\017 \027\026\017\002\024\035\036\036 \004\026\f\021\t\n\017 \r\ )Tj /Span<>> BDC ( )Tj EMC (\023\026\027\036\035\017 \024\023\030\036\007\036)Tj 0 Tw (-)Tj 0 -1.218 TD (\035\016\036\n\t\b \020\017\f\021\024\035\024\020\017\004\036\f\022\017\b\ \023\030\017\027\026\022\024\r.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 42.5896 517.8038 Tm [(\037\036)10(\032\223\212\226\034\022\031\034)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0 Tc -0.002 Tw 10 0 0 10 42.5197 493.4478 Tm [(\230\026\022\017\n )0.5(\024\002\030\026\024\n, )0.6(\r)]TJ /Span<>> BDC ( )Tj EMC 7.293 0 Td [(\023\030\017\n\036\027\036\027\017\017 )0.6(\n\024\030\235\024\035\024\020\017\004\036\f\022\017\b )0.6(\023\030\017)]TJ 0 Tw (-)Tj 0.155 Tw -7.293 -1.218 Td (\027\026\022\024\r \022\026\022 \023\030\036\007\017\022\021\024\030\024\ \r \n\036\021\026\f\021\026\017\030\024\r\026\027\017\016 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\025\217\217 )Tj 0.271 Tw T* (\2301 \024\007\027\024\005 \017)Tj /Span<>> BDC ( )Tj EMC (\r\026\032\027\t\b \023\030\024\002\035\036\n \016\r\035\016\036\021\f\016\ \017\b \027\017\022\026\016 )Tj 0.078 Tw T* (\r\024\f\023\030\024\017\r\024\007\017\n\024\f\021\034 \f\030\036\007\017\ \023\026\021\024\035\024\020\024\r, \024\002\031\f\035\024\r\035\036\027\ \027\026\016 )Tj 0.044 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\024\007\027\024\005 \f\021\024\030\024\027\t \f\023\036\006\017\235\017\ \022\024\005 \023\030\036\007\035\026\020\026\036\n\t\b \n\036\021\024\007\ \017\022 )Tj 0.033 Tw T* (\024\006\036\027\022\017, \f)Tj /Span<>> BDC ( )Tj EMC (\007\030\031\020\024\005 \f\021\024\030\024\027\t)Tj /Span<>> BDC ( )Tj EMC (\227 \f\031\002\255\036\022\021\017\r\027\024\f\021\034\033 \017)Tj /Span<>> BDC ( )Tj EMC (\022\r\026)Tj 0 Tw (-)Tj 0.237 Tw T* [(\035\017\235\017\022\026\006\017\036\005 )0.6(\023\026\021\024\035\024\020\026. )0.5(\225\021\026 )0.6(\023\030\024\002\035\036\n\026 )0.5(\022\026\f\026\036\021\f\016 )0.5(\r\f\036\b )]TJ 0.249 Tw T* (\030\036\022\024\n\036\027\007\024\r\026\027\027\t\b \r)Tj /Span<>> BDC ( )Tj EMC [(\027\026\f\021\024\016\013\036\036 )0.5(\r\030\036\n\016 \020\017\f\021\024\035\024\020\017\004\036)]TJ 0 Tw (-)Tj 0.266 Tw T* (\f\022\017\b \023\030\017\027\026\022\024\r. \200)Tj /Span<>> BDC ( )Tj EMC (\n\031\035\034\021\017\006\036\027\021\030\024\r\024\n \017\f\f\035\036\007\ \024\r\026\027\017\017 )Tj 0.121 Tw T* (Ueno)Tj /Span<>> BDC ( )Tj EMC (H. \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. [48] \023\030\017\r\024\007\016\021\f\016 \007\026\027\ \027\t\036 \024)Tj /Span<>> BDC ( )Tj EMC (\023\024\022\026\026)Tj 0 Tw (-)Tj 0.213 Tw T* (\021\036\035\016\b \r\024\f\023\030\024\017\r\024\007\017\n\024\f\021\017\ \024\006\036\027\022\017 \020\035\031\002\017\027\t \017\027\r\026\017\ \017 )Tj 0.091 Tw T* (\023\024)Tj /Span<>> BDC ( )Tj EMC (\f\030\026\r\027\036\027\017\033 \f)Tj /Span<>> BDC ( )Tj EMC (\020\017\f\021\024\035\024\020\017\004\036\f\022\017\n\017 \023\030\017\ \027\026\022\026\n\017: \027\026)Tj 0 Tw (-)Tj T* (\004\036\027\017\036 )Tj /T1_3 1 Tf 2.795 0 Td (k)Tj /T1_1 1 Tf 0.129 Tw ( \007\035\016 \020\035\031\002\017\027\t \017\027\r\026\017\017 \(DSI\)\ \002\t\035 \030\026\r\036\027 0,21, )Tj 0.058 Tw -2.795 -1.218 Td (\r)Tj /Span<>> BDC ( )Tj EMC (\021\024 \r\030\036\n\016 \022\026\022 \007\035\016 PDC )Tj /T1_3 1 Tf 0 Tw (k)Tj /T1_1 1 Tf 0.058 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,51, \007\035\016 \f\021\036\023\036\027\017 \007\017\235\235\036)Tj 0 Tw (-)Tj 0.024 Tw T* [(\030\036\027\006\017\030\024\r\022\017 \024\023\031\b\024\035\017 \(G)20(r)-33(ade\) )]TJ /T1_3 1 Tf 0 Tw (k)Tj /T1_1 1 Tf 0.024 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,48, \007\035\016 \f\024\f\031\007\017\f\021\024\005 )Tj -0.041 Tw T* (\017\027\r\026\017\017 \027\026\004\036\027\017\036 )Tj /T1_3 1 Tf 0 Tw (k)Tj /T1_1 1 Tf -0.041 Tw ( \f\024\f\021\026\r\017\035\024 0,33, \007\035\016 Bd)Tj /Span<>> BDC ( )Tj EMC (\227 )Tj /T1_3 1 Tf 0 Tw (k)Tj /T1_1 1 Tf -0.041 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,29. )Tj T* (\224\035\036\007\031\036\021 \024\021\n\036\021\017\021\034, \004\021\024\ \027\026\004\036\027\017\036 )Tj /T1_3 1 Tf 0 Tw 12.967 0 Td (k)Tj /T1_1 1 Tf -0.041 Tw ( \007\035\016 \020\017\f\021\024\035\024\020\017\004\036\f\022\017\b )Tj -0.008 Tw -12.967 -1.218 Td (\023\030\017\027\026\022\024\r \027\036 \023\024\007\027\017\n\026\035\024\ \f\034 \r\t\001\036 \031\n\036\030\036\027\027\024\020\024 \023\024\022\026\ \026)Tj 0 Tw (-)Tj -0.023 Tw T* (\021\036\035\016 \f\024\020\035\026\f\017\016, \004\021\024 \024\021\030\ \026\032\026\036\021 \024\002\013\031\033 \023\030\024\002\035\036\n\031\ \r\024\f\023\030\024)Tj 0 Tw (-)Tj 0.072 Tw T* (\017\r\024\007\017\n\024\f\021\017 \023\030\036\007\035\026\020\026\036\ \n\t\b \022\030\017\021\036\030\017\036\r \r)Tj /Span<>> BDC ( )Tj EMC (\n\024\030\235\024\035\024\020\017)Tj 0 Tw (-)Tj T* (\004\036\f\022\017\b \017\f\f\035\036\007\024\r\026\027\017\016\b.)Tj 0.324 Tw T* (\213\013\036 \024\007\027\024\005 \023\030\024\002\035\036\n\024\005 \017\ \f\023\024\035\034\024\r\026\027\017\016 \n\024\030\235\024\035\024\020\ \017)Tj 0 Tw (-)Tj 0.47 Tw T* (\004\036\f\022\017\b \023\030\017\027\026\022\024\r \022\026\022 \023\030\ \036\007\017\022\021\024\030\024\r \n\036\021\026\f\021\026\017\030\024\ )Tj 0 Tw (-)Tj 0.287 Tw T* (\r\026\027\017\016 \016\r\035\016\036\021\f\016 \017\b \r\026\030\017\026\ \002\036\035\034\027\026\016 \004\031\r\f\021\r\017\021\036\035\034\027\024\ \f\021\034 )Tj 0.184 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC 0.934 0 Td [(\007\024\r\024\035\034\027\024 )0.5(\027\017\022\026\016 )0.5(\f\023\036\006\017\235\017\004\027\024\f\021\034. )0.5(\215\024)]TJ /Span<>> BDC ( )Tj EMC 16.163 0 Td (\030\036\031\035\034\021\026\021\026\n )Tj 0.187 Tw -17.097 -1.218 Td (\023\030\024\r\036\007\036\027\027\t\b \024\002\024\030\024\r \017)Tj /Span<>> BDC ( )Tj EMC (\n\036\021\026\026\027\026\035\017\026 \017\f\f\035\036\007\024\r\026\027\ \017\005 )Tj 0.128 Tw T* [(\027\017 )0.5(\024\007\017\027 \017)]TJ /Span<>> BDC ( )Tj EMC [(\020\017\f\021\024\035\024\020\017\004\036\f\022\017\b )0.6(\023\030\017\027\026\022\024\r \027\036 )0.5(\024\002\035\026\007\026\036\021 )]TJ 0.182 Tw T* (\024\007\027\024\r\030\036\n\036\027\027\024 \007\024\f\021\026\021\024\004\ \027\024\005 \f\023\036\006\017\235\017\004\027\024\f\021\034\033 \017)Tj /Span<>> BDC ( )Tj EMC (\004\031\r)Tj 0 Tw (-)Tj 0.129 Tw T* (\f\021\r\017\021\036\035\034\027\024\f\021\034\033, \023\024\r\024\035\016\ \033\013\036\005 \017\f\023\024\035\034\024\r\026\021\034 \036\020\024 \ \022\026\022 )Tj 0.077 Tw T* (\f\026\n\024\f\021\024\016\021\036\035\034\027\t\005 \023\030\024\020\027\ \024\f\021\017\004\036\f\022\017\005 \235\026\022\021\024\030. \204\027\024\ \020\017\n\017 )Tj 0.355 Tw T* [(\017\f\f\035\036\007\024\r\026\021\036\035\016\n\017 )0.5(\r\t\f\022\026\t\r\026\036\021\f\016 \n\027\036\027\017\036, \004\021\024\ \027\026\017)]TJ 0 Tw (-)Tj 0.16 Tw T* [(\002\024\035\036\036 \021\024\004\027\024\036 \024\023\030\036\007\036\035\ \036\027\017\036 )0.5(\030\017\f\022\026 \n\036\021\026\f\021\026\017\030\024\r\026\027\017\016\ )]TJ 0.338 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\035\017\n\235\024\031\035\t \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\025\217\217 \2301 \r\024\n\024\032\027\024 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\017\f\023\024\035\034)Tj 0 Tw (-)Tj 0.568 Tw T* (\024\r\026\027\017\017 \022\024\n\002\017\027\026\006\017\017 \020\017\f\ \021\024\035\024\020\017\004\036\f\022\017\b \023\030\017\027\026\022\024\ \r )Tj 0.288 Tw T* ([7,26,75\22679]. \210\007\027\026\022\024 \r)Tj /Span<>> BDC ( )Tj EMC (\007\036\005\f\021\r\031\033\013\017\b \030\031\022\024\r\024\007\f\021\r\ \026\b )Tj -0.039 Tw 23.244 64.543 Td (\017)Tj /Span<>> BDC ( )Tj EMC (\r \022\035\017\027\017\004\036\f\022\024\005 \023\030\026\022\021\017\022\ \036 \r\f\036 \036\013\036 \007\036\005\f\021\r\031\036\021 \023\030\026\ \r\017\035\024, )Tj -0.012 Tw 0 -1.218 TD (\004\021\024 \027\026\035\017\004\017\036 \b\024\021\016 \002\t \024\007\ \027\024\020\024 \023\030\024\020\027\024\f\021\017\004\036\f\022\017 \027\ \036\002\035\026\020\024)Tj 0 Tw (-)Tj -0.03 Tw 0 -1.218 TD (\023\030\017\016\021\027\024\020\024 \020\017\f\021\024\035\024\020\017\004\ \036\f\022\024\020\024 \023\030\017\027\026\022\026 \016\r\035\016\036\021\ \f\016 \023\024\022\026)Tj 0 Tw (-)Tj -0.014 Tw 0 -1.218 TD (\026\027\017\036\n \022)Tj /Span<>> BDC ( )Tj EMC [(\007\024\023\024\035\027\017\021\036\035\034\027\024\n\031 \b\017\030\031\ \030\020\017\004\036\f\022\024\n\031 )0.5(\035\036\004\036\027\017\033. )]TJ -0.006 Tw 0 -1.218 TD (\200)Tj /Span<>> BDC ( )Tj EMC (\030\016\007\036 \023\030\024\r\036\007\036\027\027\t\b \017\f\f\035\036\ \007\024\r\026\027\017\005 \023\030\036\007\023\030\017\027\017\n\026\035\ \017\f\034 )Tj 0.482 Tw 0 -1.218 TD (\023\024\023\t\021\022\017 \f\024\007\026\027\017\016 \023\030\024\020\027\ \024\f\021\017\004\036\f\022\017\b \n\024\007\036\035\036\005 \007\035\016\ )Tj 0.029 Tw 0 -1.218 TD (\031\035\031\004\001\036\027\017\016 \021\024\004\027\024\f\021\017 \024\ \006\036\027\022\017 \030\017\f\022\026 \n\036\021\026\f\021\026\017\030\ \024\r\026\027\017\016 )Tj 0.048 Tw 0 -1.218 TD (\023\030\017)Tj /Span<>> BDC ( )Tj EMC [(\2301 \025\217\217. Ba)-17(ck)10(es)]TJ /Span<>> BDC ( )Tj EMC (Y. \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. [26] \f\030\026\r\027\017\035\017 \030\026\027\t\036 \ )Tj 0.167 Tw T* (\n\024\007\036\035\017 \007\035\016 \024\006\036\027\022\017 \030\017\f\022\ \026 \n\036\021\026\f\021\026\017\030\024\r\026\027\017\016 \n\026\035\017\ \020)Tj 0 Tw (-)Tj 0.129 Tw T* (\027\017\017\030\024\r\026\027\027\t\b \023\024\035\017\023\024\r \021\024\ \035\f\021\024\005 \022\017\001\022\017 \030\2301, \r\022\035\033\004\026\ )Tj 0 Tw (-)Tj 0.268 Tw T* (\033\013\017\036 \022\024\n\002\017\027\026\006\017\017 \020\017\f\021\024\ \035\024\020\017\004\036\f\022\017\b \023\030\017\027\026\022\024\r, \f\ \024)Tj 0 Tw (-)Tj 0.303 Tw T* [(\024\021\r\036\021\f\021\r\036\027\027\024 \030\031\022\024\r\024\007\f\021\ \r\026\n A)35(SGE/ESGE \(\n\024\007\036\035\034 1\), )]TJ 0.198 Tw T* (JSCCR \(\n\024\007\036\035\034 2\) \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\002\f\021\r\036\027\027\t\036 \r\026\030\017\026\027\021\t \n\024\ \007\036\035\017, )Tj -0.011 Tw T* (\r\022\035\033\004\026\033\013\017\036 \022\024\n\002\017\027\026\006\017\ \033 \024\f\027\024\r\027\t\b \020\017\f\021\024\035\024\020\017\004\036\ \f\022\017\b )Tj 0.168 Tw T* (\023\030\017\027\026\022\024\r \(\027\017\022\026\016 \007\017\235\235\ \036\030\036\027\006\017\030\024\r\022\026 \024\023\031\b\024\035\017, \020\ \035\031)Tj 0 Tw (-)Tj 0.225 Tw T* (\002\017\027\026 \017\027\r\026\017\017, \035\017\n\235\024\r\026\f\022\ \031\035\016\030\027\026\016 \017\027\r\026\017\016\), \007\024\023\024\ \035)Tj 0 Tw (-)Tj 0.145 Tw T* (\027\036\027\027\t\b \022\030\017\021\036\030\017\016\n\017 Bd \017)Tj /Span<>> BDC ( )Tj EMC (PDC \r)Tj /Span<>> BDC ( )Tj EMC (\030\026\027\t\b \f\024\004\036\021\026\027\017\016\b. )Tj 0.264 Tw T* (\217\026\030\026\002\024\021\026\027\027\t\036 \026\r\021\024\030\026\n\ \017 \n\024\007\036\035\017 \023\024\022\026\026\035\017 \035\031\004\001\ \017\005 )Tj 0.05 Tw T* (\023\030\036\007\017\022\021\017\r\027\t\005 \030\036\031\035\034\021\026\ \021 \023\024)Tj /Span<>> BDC ( )Tj EMC (\024\006\036\027\022\036 \030\017\f\022\026 \n\036\021\026\f\021\026\017\ )Tj 0 Tw (-)Tj -0.041 Tw T* [(\030\024\r\026\027\017\016: )0.5(A)17(UC)]TJ /Span<>> BDC ( )Tj EMC 5.717 0 Td (=)Tj /Span<>> BDC ( )Tj EMC 0.692 0 Td [(0,83 )0.5(\(95% CI )0.5(0,76\2260,90\), )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC [(\021\024 )0.5(\r\030\036\n\016 )0.5(\022\026\022 )]TJ 0.123 Tw -6.409 -1.218 Td (\n\024\007\036\035\017 1 \017)Tj /Span<>> BDC ( )Tj EMC (2 \023\024\022\026\026\035\017 \002\024\035\036\036 \027\017\022\017\036\ \030\036\031\035\034\021\026\021\t)Tj /Span<>> BDC ( )Tj EMC (\227 )Tj 0.041 Tw T* [(A)17(UC)]TJ /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,67 \(95% CI 0,60\2260,74; )Tj /T1_3 1 Tf 0 Tw (\033)Tj /T1_1 1 Tf 0.041 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,002\) \017)Tj /Span<>> BDC ( )Tj EMC [(A)17(UC)]TJ /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,64 )Tj 0.512 Tw T* (\(95% CI 0,58\2260,70; )Tj /T1_3 1 Tf 0 Tw (\033)Tj /T1_1 1 Tf 0.512 Tw /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (0,001\), \f\024\024\021\r\036\021\f\021\r\036\027\027\024. )Tj 0.192 Tw T* (\217\026\030\026\002\024\021\026\027\027\026\016 \n\024\007\036\035\034\ \024\023\030\036\007\036\035\016\035\026 \023\026\006\017\036\027\021\024\ \r, \027\031\032)Tj 0 Tw (-)Tj 0.017 Tw T* (\007\026\033\013\017\b\f\016 \r)Tj /Span<>> BDC ( )Tj EMC (\007\024\023\024\035\027\017\021\036\035\034\027\024\n \035\036\004\036\027\ \017\017, \f)Tj /Span<>> BDC ( )Tj EMC (\004\031\r\f\021\r\017\021\036\035\034)Tj 0 Tw (-)Tj 0.077 Tw T* (\027\024\f\021\034\033 83,8% \017)Tj /Span<>> BDC ( )Tj EMC (\f\023\036\006\017\235\017\004\027\024\f\021\034\033 70,3%, \023\030\017\ )Tj /Span<>> BDC ( )Tj EMC (\220\021\024\n \017\b )Tj 0.223 Tw T* (\022\024\035\017\004\036\f\021\r\024 \002\t\035\024 \f\031\013\036\f\021\ \r\036\027\027\024 \027\017\032\036)Tj /Span<>> BDC ( )Tj EMC (\227 32,5%, \004\036\n )Tj 0 Tw T* (\023\030\036\007\f\022\026\t\r\026\035\017 \n\024\007\036\035\017 1)Tj /Span<>> BDC ( )Tj EMC (\(56,6%\) \017)Tj /Span<>> BDC ( )Tj EMC (2)Tj /Span<>> BDC ( )Tj EMC (\(65,5%\).)Tj 0.246 Tw T* [(T)40(anino)]TJ /Span<>> BDC ( )Tj EMC (F. \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. \(2024\) [80] \023\030\024\r\036\035\017 \f\030\026\r\027\ \036\027\017\036 )Tj 0.409 Tw T* (\023\030\024\020\027\024\f\021\017\004\036\f\022\024\005 \220\235\235\036\ \022\021\017\r\027\024\f\021\017 \023\030\036\007\017\022\021\024\030\024\ \r \n\036)Tj 0 Tw (-)Tj 0.198 Tw T* [(\021\026\f\021\026\017\030\024\r\026\027\017\016, )0.5(\r\022\035\033\004\036\027\027\t\b \r)]TJ /Span<>> BDC ( )Tj EMC (\030\026\027\t\036 \030\031\022\024\r\024\007\f\021\r\026 )Tj 0.278 Tw T* (\023\024)Tj /Span<>> BDC ( )Tj EMC (\035\036\004\036\027\017\033 \030\2301 \025\217\217. \200)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \017)Tj /Span<>> BDC ( )Tj EMC (560 \023\026\006\017\036\027\021\024\r )Tj -0.007 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\025\217\217 \030\2301 \030\036\021\030\024\f\023\036\022\021\017\r\027\024\ \002\t\035 \023\030\024\r\036\007\036\027 \024\021\002\024\030 \r)Tj /Span<>> BDC ( )Tj EMC (\023\024\007)Tj 0 Tw (-)Tj 0.142 Tw T* (\020\030\031\023\023\t \f)Tj /Span<>> BDC ( )Tj EMC (\027\017\022\017\n \017)Tj /Span<>> BDC ( )Tj EMC (\r\t\f\024\022\017\n \030\017\f\022\024\n \n\036\021\026\f\021\026\017\030\ \024\r\026)Tj 0 Tw (-)Tj 0.14 Tw T* (\027\017\016 \r)Tj /Span<>> BDC ( )Tj EMC (\035\017\n\235\024\031\035\t, \017\f\023\024\035\034\031\016 \022\030\017\ \021\036\030\017\017, \r\022\035\033\004\036\027\027\t\036 )Tj 0.463 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\030\031\022\024\r\024\007\f\021\r\026 JSCCR \(\f\021\036\023\036\027\034\ \007\017\235\235\036\030\036\027\006\017\030\024\r\022\017 )Tj 0.511 Tw T* (\026\007\036\027\024\022\026\030\006\017\027\024\n\t, \020\035\031\002\017\ \027\026 \023\024\007\f\035\017\017\f\021\024\005 \017\027\r\026\017\017\ , )Tj 0.13 Tw T* (\035\017\n\235\024\r\026\f\022\031\035\016\030\027\026\016 \017\027\r\026\ \017\016 \017)Tj /Span<>> BDC ( )Tj EMC (\024\023\031\b\024\035\036\r\t\005 \002\026\007\007\017\027\020\), )Tj -0.02 Tw T* (NCCN \(\f\021\036\023\036\027\034 \007\017\235\235\036\030\036\027\006\017\ \030\024\r\022\017 \202\212\025 \017)Tj /Span<>> BDC ( )Tj EMC (\035\017\n\235\024\r\026\f\022\031)Tj 0 Tw (-)Tj 0.053 Tw T* (\035\016\030\027\026\016 \017\027\r\026\017\016\) \017)Tj /Span<>> BDC ( )Tj EMC (ESMO \(\f\021\036\023\036\027\034 \007\017\235\235\036\030\036\027\006\017\ \030\024\r\022\017 )Tj 0.098 Tw T* (\202\212\025, \035\017\n\235\024\r\026\f\022\031\035\016\030\027\026\016\ \017\027\r\026\017\016 \017)Tj /Span<>> BDC ( )Tj EMC (\024\023\031\b\024\035\036\r\t\005 \002\026\007)Tj 0 Tw (-)Tj 0.199 Tw T* (\007\017\027\020\). \200)Tj /Span<>> BDC ( )Tj EMC (\017\f\f\035\036\007\024\r\026\027\027\024\005 \020\030\031\023\023\036 \ 45)Tj /Span<>> BDC ( )Tj EMC (\(8%\) \023\026\006\017\036\027\021\024\r )Tj 0.113 Tw T* (\017\n\036\035\017 \n\036\021\026\f\021\026\t \r)Tj /Span<>> BDC ( )Tj EMC (\035\017\n\235\024\031\035\026\b. \224\024\020\035\026\f\027\024 \017\f\ \023\024\035\034\024)Tj 0 Tw (-)Tj 0.161 Tw T* (\r\026\027\027\t\n \022\030\017\021\036\030\017\016\n, \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\031 \f)Tj /Span<>> BDC ( )Tj EMC (\r\t\f\024\022\017\n \030\017\f\022\024\n \n\036)Tj 0 Tw (-)Tj 0.058 Tw T* (\021\026\f\021\026\017\030\024\r\026\027\017\016 \027\026)Tj /Span<>> BDC ( )Tj EMC (\024\f\027\024\r\036 \022\030\017\021\036\030\017\036\r JSCCR \002\t\035\ \024\021\024)Tj 0 Tw (-)Tj 0.113 Tw T* (\002\030\026\027 461 \023\026\006\017\036\027\021, \004\021\024 \002\t\035\ \024 \f\031\013\036\f\021\r\036\027\027\024 \r\t\001\036, \004\036\n )Tj 0.11 Tw T* (\023\030\017)Tj /Span<>> BDC ( )Tj EMC (\017\f\023\024\035\034\024\r\026\027\017\017 \022\030\017\021\036\030\017\ \036\r NCCN)Tj /Span<>> BDC ( )Tj EMC (\227 291 \023\026\006\017\036\027\021 )Tj -0.014 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\022\030\017\021\036\030\017\036\r ESMO)Tj /Span<>> BDC ( )Tj EMC (\227 303 \023\026\006\017\036\027\021\026. )Tj /T1_3 1 Tf -0.019 Tc 0.019 Tw [(RO)-18.9(C)]TJ /T1_1 1 Tf 0 Tc -0.014 Tw 16.365 0 Td (-\026\027\026\035\017 \023\030\036\007)Tj 0 Tw (-)Tj 0.1 Tw -16.365 -1.218 Td (\f\022\026\026\021\036\035\034\027\024\005 \220\235\235\036\022\021\017\ \r\027\024\f\021\017 \022\026\032\007\024\020\024 \017)Tj /Span<>> BDC ( )Tj EMC (\017\031\004\026\036\n\t\b )Tj 0.347 Tw T* (\030\031\022\024\r\024\007\f\021\r \023\024\022\026\026\035 \f\035\036\007\ \031\033\013\017\036 \030\036\031\035\034\021\026\021\t: \r\036\035\017\ )Tj 0 Tw (-)Tj 0.145 Tw T* [(\004\017\027\t A)17(UC \007\035\016 JSCCR, NCCN \017)]TJ /Span<>> BDC ( )Tj EMC (ESMO \f\024\f\021\026\r\017\035\017 0,596, )Tj 0.196 Tw T* (0749 \017)Tj /Span<>> BDC ( )Tj EMC (0,743, \f\024\024\021\r\036\021\f\021\r\036\027\027\024. \200\f\036 \030\ \031\022\024\r\024\007\f\021\r\026 \023\024)Tj 0 Tw (-)Tj 0.446 Tw T* (\022\026\026\035\017 \r\t\f\024\022\031\033 \004\031\r\f\021\r\017\021\036\ \035\034\027\024\f\021\034 \(98\226100%\), \027\024 )Tj 0.076 Tw T* [(\027\017\022\031\033 \f\023\036\006\017\235\017\004\027\024\f\021\034 )0.5(\(JSCCR)]TJ /Span<>> BDC ( )Tj EMC (\227 19%, NCCN)Tj /Span<>> BDC ( )Tj EMC (\227 52% )Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 0 Tw 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\206)10(\002\036\033 \035\030\032\003\033)30(\n)42(\032)-21(\230\033\241)]TJ 57.136 0 Td (REVIEW)Tj /T1_4 1 Tf 25 0 0 25 505.5021 56.0378 Tm (183)Tj ET endstream endobj 1010 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.08 Tw 10 0 0 10 70.8661 724.8299 Tm (\240\025\230 \200\210\003 \(2019\) [50] \002\t\035\026 \031\023\030\024\013\ \036\027\026 \017)Tj /Span<>> BDC ( )Tj EMC (\021\030\026\027\f\235\024\030\n\017)Tj 0 Tw (-)Tj 0.115 Tw 0 -1.218 TD (\030\024\r\026\027\026 \r)Tj /Span<>> BDC ( )Tj EMC (\007\r\031\b\f\021\031\023\036\027\004\026\021\031\033 \020\030\026\007\026\ \006\017\033 \f\021\036\023\036\027\017 \035\024\022\026)Tj 0 Tw (-)Tj 0.213 Tw T* [(\004\036\f\021\r\036\027\027\024\f\021\017 \(G)20(r)-33(ade\) \026\007\036\027\024\022\026\030\006\017\027\024\n\t \r)]TJ /Span<>> BDC ( )Tj EMC (\r\017\007\036 \022\026\030)Tj 0 Tw (-)Tj 0.047 Tw T* [(\006\017\027\024\n\t l)30(o)-14(w gr)-33(ade \(\r\022\035\033\004\026\033\013\036\005 \r\t\f\024\022\024- \017)]TJ /Span<>> BDC ( )Tj EMC (\031\n\036\030\036\027\027\024 )Tj 0.134 Tw T* [(\007\017\235\235\036\030\036\027\006\017\030\024\r\026\027\027\t\036 )0.5(\r\026\030\017\026\027\021\t\) \017)]TJ /Span<>> BDC ( )Tj EMC [(\022\026\030\006\017\027\024\n\t )0.5(high )]TJ 0.931 Tw T* [(gr)-33(ade \(\r\022\035\033\004\026\033\013\017\036 \027\017\022\024\007\017\235\ \235\036\030\036\027\006\017\030\024\r\026\027\027\t\036 )]TJ 0.286 Tw 0 -1.218 TD (\026\007\036\027\024\022\026\030\006\017\027\024\n\t \017)Tj /Span<>> BDC ( )Tj EMC (\027\036\007\017\235\235\036\030\036\027\006\017\030\024\r\026\027\027\t\ \036 \030\026\022\017\). )Tj 0.264 Tw 0 -1.218 TD (\210\023\030\036\007\036\035\036\027\027\t\036 \030\026\035\017\004\017\ \016 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\024\006\036\027\022\036 \f\021\036\023\036\027\017 \007\017\235)Tj 0 Tw (-)Tj 0.353 Tw T* (\235\036\030\036\027\006\017\030\024\r\022\017 \025\217\217 \017\n\036\033\ \021\f\016 \n\036\032\007\031 \036\r\030\024\023\036\005\f\022\017\n\017\ )Tj 0.222 Tw T* (\023\026\021\024\035\024\020\026\n\017, \017\f\023\024\035\034\031\033\013\ \017\n\017 \022\030\017\021\036\030\017\017 \022\035\026\f\f\017\235\017\ \022\026)Tj 0 Tw (-)Tj 0.183 Tw T* (\006\017\017 \200\210\003, \020\007\036 \007\026\027\027\t\005 \023\030\017\ \027\026\022 \030\036\022\024\n\036\027\007\031\036\021\f\016 \024\023\030\ \036)Tj 0 Tw (-)Tj 0.358 Tw T* (\007\036\035\016\021\034 \023\024)Tj /Span<>> BDC ( )Tj EMC [(\027\026\017\n\036\027\036\036 \007\017\235\235\036\030\036\027\006\017\030\ \024\r\026\027\027\t\n )0.5(\f\021\030\031\022)]TJ 0 Tw (-)Tj 0.375 Tw 0 -1.218 TD (\021\031\030\026\n \024\023\031\b\024\035\017, \017)Tj /Span<>> BDC ( )Tj EMC (\022\030\017\021\036\030\017\016\n\017, \030\036\022\024\n\036\027\007\024\ \r\026\027\027\t\n\017 )Tj 0.094 Tw 0 -1.218 TD (\r)Tj /Span<>> BDC ( )Tj EMC (\030\031\022\024\r\024\007\f\021\r\036 JSCCR, \020\007\036 \f\021\036\023\ \036\027\034 \007\017\235\235\036\030\036\027\006\017\030\024\r\022\017 \ )Tj 0.161 Tw 0 -1.218 TD (\026\007\036\027\024\022\026\030\006\017\027\024\n\t \024\023\030\036\007\ \036\035\016\036\021\f\016 \023\024)Tj /Span<>> BDC ( )Tj EMC (\023\030\036\024\002\035\026\007\026\033\013\036\n\031 )Tj 0 Tw T* (\022\024\n\023\024\027\036\027\021\031 [12,13,50,51,52].)Tj /T1_1 1 Tf 0.535 Tw 0 -2.436 TD (\216\016\020\034\006\016\020 \253\f\034\005\021\034\036\037\020\022\030\273\ \034\f\023\002\034\027\022 \(tumor budding\) )Tj -0.004 Tw 0 -1.218 TD (\022)Tj /Span<>> BDC ( )Tj EMC (\f\027\034\002\034 \b\022\017\017\016\033\016\020\007\022\033\034\036\037\ \020\020\032\016 \021\027\037\024\035\016\033\032 \(PDC\) \f\034)Tj /Span<>> BDC ( )Tj EMC (\022\020)Tj 0 Tw (-)Tj T* (\036\037\031\022\036\020\034\006\023 \017\033\034\020\035\023 \034\f\023\ \002\034\027\022.)Tj /T1_0 1 Tf 0.027 Tw T* [(\200 )0.5(\021\024\032\036 )0.5(\r\030\036\n\016, )0.6(\r)]TJ /Span<>> BDC ( )Tj EMC [(\022\035\026\f\f\017\235\017\022\026\006\017\017 )0.5(\200\210\003 )0.5(\027\036 )0.6(\030\036\022\024\n\036\027\007\031\036\021)]TJ 0 Tw (-)Tj 0.123 Tw T* (\f\016 \031\004\017\021\t\r\026\021\034 \027\017\022\024\007\017\235\235\ \036\030\036\027\006\017\030\024\r\026\027\027\t\036 \f\021\030\031\022\021\ \031\030\t )Tj 0.274 Tw T* [(\017\027\r\026\017\r\027\024\020\024 )0.5(\235\030\024\027\021\026 )0.5(\024\023\031\b\024\035\017 \023\030\017)]TJ /Span<>> BDC ( )Tj EMC 15.218 0 Td [(\024\006\036\027\022\036 \036\036 )0.5(\007\017\235)]TJ 0 Tw (-)Tj 0.292 Tw -15.218 -1.218 Td [(\235\036\030\036\027\006\017\030\024\r\022\017/\035\024\022\026\004\036\ \f\021\r\036\027\027\024\f\021\017 \(G)20.1(r)-33(ade\), \022\024\021\024\030\t\036 )]TJ 0.151 Tw T* (\f\035\036\007\031\036\021 \024\023\017\f\t\r\026\021\034 \024\021\007\036\ \035\034\027\024. \210\007\027\026\022\024 \017\031\004\036\027\017\036\ \007\026\027)Tj 0 Tw (-)Tj 0.12 Tw T* (\027\t\b \f\021\030\031\022\021\031\030 \r)Tj /Span<>> BDC ( )Tj EMC (\024\027\036 \017\027\r\026\017\017 \024\023\031\b\024\035\017 \023\024\ \022\026\026\035\024, \004\021\024 )Tj 0.271 Tw T* (\017\n\036\027\027\024 \220\021\017 \027\026\017\n\036\027\036\036 \007\017\ \235\235\036\030\036\027\006\017\030\024\r\026\027\027\t\036 \017)Tj /Span<>> BDC ( )Tj EMC (\007\036)Tj 0 Tw (-)Tj 0.613 Tw T* (\007\017\235\235\036\030\036\027\006\017\030\024\r\026\027\027\t\036 \020\ \017\f\021\024\035\024\020\017\004\036\f\022\017\036 \f\021\030\031\022\021\ \031\030\t )Tj 0.132 Tw T* (\026\007\036\027\024\022\026\030\006\017\027\024\n\t \r)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\034\001\036\005 \f\021\036\023\036\027\017 \024\023\030\036\ \007\036\035\016\033\021 \036\036 )Tj 0.021 Tw T* (\002\017\024\035\024\020\017\004\036\f\022\031\033 \026\020\030\036\f\f\017\ \r\027\024\f\021\034 [53\22657]. \204\036\035\022\017\036 \020\030\031\023\ )Tj 0 Tw (-)Tj 0.076 Tw T* (\023\t \022\035\036\021\024\022 \017)Tj /Span<>> BDC ( )Tj EMC (\036\007\017\027\017\004\027\t\036 \022\035\036\021\022\017 \r)Tj /Span<>> BDC ( )Tj EMC (\024\027\036 \017\027\r\026\017\017 \002\t\035\017 )Tj 0.037 Tw T* (\024\023\017\f\026\027\t \022\026\022 tumor budding, \024\002\024\027\026\ \004\026\033\013\017\005 \235\036\027\024\n\036\027 )Tj 0.231 Tw T* (\253\023\024\004\022\024\r\026\027\017\016\273 \024\023\031\b\024\035\036\ \r\t\b \032\036\035\036 [53], \002\024\035\036\036 \022\030\031\023)Tj 0 Tw (-)Tj 0.238 Tw T* (\027\t\036 \f\022\024\023\035\036\027\017\016 \022\035\036\021\024\022)Tj /Span<>> BDC ( )Tj EMC [(\227 \022\026\022 po)-16(or)-29.9(l)35(y dif)-56(fer)-23.9(ent)-32(ia)15(ted )]TJ 0.057 Tw T* [(cl)35(uster)-9.9(s, \023\030\036\007\f\021\026\r\035\016\033\013\017\036 \f\024\002\024\005\ \024\004\026\020\024\r\t\036 \f\022\024\023\035\036\027\017\016 )]TJ 0.358 Tw T* [(\(\022\035\026\f\021\036\030\t\) \024\023\031\b\024\035\036\r\t\b )0.5(\022\035\036\021\024\022 \002\036 \235\024\030\n\017\030\024\r\026\027\017\ \016 )]TJ 0.243 Tw T* (\032\036\035\036\017\f\021\t\b \f\021\030\031\022\021\031\030 [54]. \215\ \030\036\007\017\022\021\017\r\027\024\036 \027\026\004\036\027\017\036\ )Tj -0.025 Tw T* (tumor budding \024\021\027\024\f\017\021\036\035\034\027\024 \n\036\021\026\ \f\021\026\024\r \r)Tj /Span<>> BDC ( )Tj EMC (\035\017\n\235\024\031\035\t )Tj 0.13 Tw T* (\023\030\017)Tj /Span<>> BDC ( )Tj EMC (\025\025\217 \2301 \023\024\022\026\026\027\024 \r)Tj /Span<>> BDC ( )Tj EMC (\n\027\024\020\024\004\017\f\035\036\027\027\t\b \017\f\f\035\036\007\024\ \r\026)Tj 0 Tw (-)Tj -0.03 Tw T* [(\027\017\016\b )0.6([17,18,26,37,51,53\22657]. )0.5(\200)]TJ /Span<>> BDC ( )Tj EMC 12.615 0 Td [(\017\f\f\035\036\007\024\r\026\027\017\017 )0.6(P)20(upp)32(a)]TJ /Span<>> BDC ( )Tj EMC 8.662 0 Td (G. )Tj 0.087 Tw -21.277 -1.218 Td (\017)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. [58] \002\t\035\024 \023\030\024\r\036\007\036\027\024\ \n\036\032\007\031\027\026\030\024\007\027\024\036 \n\031\035\034)Tj 0 Tw (-)Tj 0.433 Tw T* [(\021\017\006\036\027\021\030\024\r\024\036 )0.6(\017\031\004\036\027\017\036 )0.5(\r\024\f\023\030\024\017\r\024\007\017\n\024\f\021\017 )0.6(\007\026\027\027\024)]TJ 0 Tw (-)Tj 0.235 Tw T* [(\020\024 )0.5(\023\030\017\027\026\022\026 )0.6(\f)]TJ /Span<>> BDC ( )Tj EMC 6.555 0 Td [(\017\f\023\024\035\034\024\r\026\027\017\036\n )0.5(\030\026\035\017\004\027\t\b )0.6(\n\036\021\024\007\017\022 )]TJ 0.151 Tw -6.555 -1.218 Td (\024\023\030\036\007\036\035\036\027\017\016 \017)Tj /Span<>> BDC ( )Tj EMC (\023\024\007\f\004\036\021\026, \f)Tj /Span<>> BDC ( )Tj EMC (\006\036\035\034\033 \024\023\030\036\007\036\035\017\021\034 \n\036\021\ \024)Tj 0 Tw (-)Tj 0.08 Tw T* (\007\017\022\031, \023\024\r\024\035\016\033\013\031\033 \027\026\017\002\ \024\035\036\036 \021\024\004\027\024 \r\024\f\023\030\024\017\r\024\007\ \017\021\034 )Tj -0.006 Tw T* (\007\026\027\027\t\005 \023\030\017\027\026\022 \027\026)Tj /Span<>> BDC ( )Tj EMC (\023\030\026\022\021\017\022\036. \203\026)Tj /Span<>> BDC ( )Tj EMC (\024\f\027\024\r\026\027\017\017 \023\024\035\031\004\036\027)Tj 0 Tw (-)Tj 0.306 Tw T* (\027\t\b \030\036\031\035\034\021\026\021\024\r \002\t\035\017 \030\026\ \030\026\002\024\021\026\027\t \030\036\022\024\n\036\027\007\026\006\017\ \017 )Tj 0.049 Tw T* (\023\024)Tj /Span<>> BDC ( )Tj EMC [(\n\024\030\235\024\035\024\020\017\004\036\f\022\024\005 )0.5(\024\006\036\027\022\036 )0.5(\007\026\027\027\024\020\024 \023\030\017\027\026\022\026 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC (\036\020\024 )Tj 0 Tw T* (\023\030\017\n\036\027\036\027\017\017 \r)Tj /Span<>> BDC ( )Tj EMC (\023\030\026\022\021\017\004\036\f\022\024\005 \030\026\002\024\021\036 \ [59].)Tj 0.061 Tw T* (\215\035\024\b\024 \007\017\235\235\036\030\036\027\006\017\030\024\r\026\ \027\027\t\036 \022\035\026\f\021\036\030\t \022\026\022 \022\030\017\021\ \036\030\017\005 )Tj 0.049 Tw T* [(\024\006\036\027\022\017 )0.5(\n\036\021\026\f\021\026\021\017\004\036\f\022\024\020\024 )0.6(\023\024\021\036\027\006\017\026\035\026 )0.6(\026\007\036\027\024\022\026\030\006\017\027\024)]TJ 0 Tw (-)Tj 0.013 Tw T* (\n\t \f)Tj /Span<>> BDC ( )Tj EMC (\023\024\007\f\035\017\017\f\021\024\005 \017\027\r\026\017\036\005 \002\ \t\035 \023\030\036\007\035\024\032\036\027 Ueno)Tj /Span<>> BDC ( )Tj EMC (H. )Tj 0.037 Tw T* ([48,54], \022\024\021\024\030\t\005 \027\026)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\034\001\024\005 \020\030\031\023\023\036 \017)Tj /Span<>> BDC ( )Tj EMC (3556 \023\026\006\017\036\027)Tj 0 Tw (-)Tj 0.181 Tw T* (\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\025\217\217 \2301 \023\024\022\026\026\035, \004\021\024 \007\026\027\027\ \t\005 \020\017\f\021\024\035\024\020\017\004\036\f\022\017\005 )Tj -0.019 Tw 23.244 64.543 Td (\023\030\017\027\026\022 \017\n\036\036\021 \007\024\f\021\024\r\036\030\ \027\031\033 \026\f\f\024\006\017\026\006\017\033 \f)Tj /Span<>> BDC ( )Tj EMC (\n\036\021\026\f\021\026\026)Tj 0 Tw (-)Tj -0.044 Tw T* (\n\017 \r)Tj /Span<>> BDC ( )Tj EMC (\035\017\n\235\024\031\035\t \(OR)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (3,3 \(95% CI: 2,6\2264,1\) )Tj /T1_1 1 Tf 0 Tw (P)Tj /T1_0 1 Tf -0.044 Tw /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (0,0001\) )Tj 0.681 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\035\031\004\001\031\033 \r\024\f\023\030\024\017\r\024\007\017\n\024\f\ \021\034 \f\030\036\007\017 \023\026\021\024\035\024\020\024\r )Tj -0.034 Tw T* (\023\024)Tj /Span<>> BDC ( )Tj EMC (\f\030\026\r\027\036\027\017\033 \f)Tj /Span<>> BDC ( )Tj EMC (tumor budding. \203\036\f\n\024\021\030\016 \027\026)Tj /Span<>> BDC ( )Tj EMC (\021\024, \004\021\024 \r\024 )Tj -0.022 Tw T* (\n\027\024\020\017\b \017\f\f\035\036\007\024\r\026\027\017\016\b \007\026\ \027\027\t\b \023\026\030\026\n\036\021\030 \023\024\022\026\026\035 \027\ \026)Tj 0 Tw (-)Tj 0.197 Tw T* (\004\017\n\024\036 \023\030\024\020\027\024\f\021\017\004\036\f\022\024\036\ \027\026\004\036\027\017\036 \024\021\027\024\f\017\021\036\035\034\027\ \024 \n\036)Tj 0 Tw (-)Tj 0.061 Tw 0 -1.218 TD [(\021\026\f\021\026\017\030\024\r\026\027\017\016 )0.6(\r)]TJ /Span<>> BDC ( )Tj EMC 7.569 0 Td [(\035\017\n\235\024\031\035\t )0.6([26,37,60\22664], )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 11.898 0 Td (\027\026\f\021\024)Tj 0 Tw (-)Tj 0.06 Tw -19.467 -1.218 Td (\016\013\036\036 \r\030\036\n\016 \024\021\f\031\021\f\021\r\031\033\021\ \031\027\017\235\017\006\017\030\024\r\026\027\027\026\016 \n\036\021\024\ \007\017\022\026 )Tj 0 Tw 0 -1.218 TD (\024\006\036\027\022\017 \017)Tj /Span<>> BDC ( )Tj EMC (\023\024\030\024\020\024\r\t\036 \r\036\035\017\004\017\027\t, \026)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\032\036 \022\024\027\f\036\027\f\031\f \024\021)Tj (-)Tj -0.027 Tw T* (\027\024\f\017\021\036\035\034\027\024 \r\022\035\033\004\036\027\017\016\ \220\021\024\020\024 \023\030\017\027\026\022\026 \r)Tj /Span<>> BDC ( )Tj EMC (\022\035\017\027\017\004\036\f\022\017\036 )Tj 0 Tw T* (\030\031\022\024\r\024\007\f\021\r\026 \017)Tj /Span<>> BDC ( )Tj EMC (\036\020\024 \023\030\026\022\021\017\004\036\f\022\024\020\024 \023\030\ \017\n\036\027\036\027\017\016.)Tj /T1_1 1 Tf 0 -2.436 TD (\240\f\023\002\034\027\016\036\037\030 \024\034\024\023\b\022\024\035\037\ \030 \022\020\036\037\031\022\030)Tj /T1_0 1 Tf 0.134 Tw 0 -1.218 TD (\224\024\f\031\007\017\f\021\026\016 \017\027\r\026\017\016 \016\r\035\016\ \036\021\f\016 \024\002\013\036\023\030\017\027\016\021\t\n \027\036\002\ \035\026)Tj 0 Tw (-)Tj 0.452 Tw 0 -1.218 TD [(\020\024\023\030\017\016\021\027\t\n )0.5(\023\030\024\020\027\024\f\021\017\004\036\f\022\017\n \023\030\017\027\ \026\022\024\n \023\030\017)]TJ /Span<>> BDC ( )Tj EMC (\022\024)Tj 0 Tw (-)Tj 0.21 Tw T* (\035\024\030\036\022\021\026\035\034\027\024\n \030\026\022\036 \027\036\ \026\r\017\f\017\n\024 \024\021 \f\021\026\007\017\017 \024\023\031\b\024\ \035\017. )Tj 0.22 Tw T* (\217\026\035\017\004\026\033\021 \017\027\r\026\017\033 \035\017\n\235\ \026\021\017\004\036\f\022\017\b \017)Tj /Span<>> BDC ( )Tj EMC (\022\030\024\r\036\027\024\f\027\t\b )Tj 0.294 Tw T* [(\f\024\f\031\007\024\r, )0.5(\024\007\027\026\022\024 )0.6(\r)]TJ /Span<>> BDC ( )Tj EMC 8.456 0 Td [(\023\030\026\022\021\017\004\036\f\022\024\005 )0.5(\007\036\016\021\036\035\034\027\024\f\021\017 )0.6(\017\027)]TJ 0 Tw (-)Tj 0.165 Tw -8.456 -1.218 Td (\r\026\017\016 \n\036\035\022\017\b \f\024\f\031\007\024\r, \023\030\024\ \f\r\036\021 \022\024\021\024\030\t\b \024\021\020\030\026\027\017\004\036\ \027 )Tj -0.043 Tw T* (\f\035\024\036\n \220\027\007\024\021\036\035\017\016, \004\026\f\021\024\ \024\023\017\f\t\r\026\036\021\f\016 \022\026\022 \035\017\n\235\024\r\026\ \f\022\031)Tj 0 Tw (-)Tj -0.046 Tw T* (\035\016\030\027\026\016 \017\027\r\026\017\016 \002\036 \007\036\035\036\ \027\017\016 \027\026)Tj /Span<>> BDC ( )Tj EMC (\035\017\n\235\026\021\017\004\036\f\022\017\036 \017)Tj /Span<>> BDC ( )Tj EMC (\022\030\024)Tj 0 Tw (-)Tj 0.137 Tw T* (\r\036\027\024\f\027\t\036 \f\024\f\031\007\t [65]. \210\021\007\036\035\ \034\027\024 \r\t\007\036\035\016\036\021\f\016 \r\036\027\024)Tj 0 Tw (-)Tj 0.087 Tw T* (\027\026\016 \017\027\r\026\017\016, \023\024\f\022\024\035\034\022\031\ \024\027\026 \f\r\016\026\027\026 \f)Tj /Span<>> BDC ( )Tj EMC (\020\036\n\026\021\024\020\036\027\027\t\n )Tj -0.002 Tw T* (\017, \023\030\036\017\n\031\013\036\f\021\r\036\027\027\024, \024\021\007\ \026\035\036\027\027\t\n \n\036\021\026\f\021\026\017\030\024\r\026\027\ \017\036\n )Tj 0.571 Tw T* [(\024\023\031\b\024\035\017. )0.5(\214\017\n\235\024\r\026\f\022\031\035\016\030\027\026\016 )0.6(\017\027\r\026\017\016 )0.5(\030\026\f\f\n\026\021\030\017)]TJ 0 Tw (-)Tj 0.362 Tw T* (\r\026\036\021\f\016, \022\026\022 \024\f\027\024\r\027\024\005 \n\036\b\ \026\027\017\n \n\036\021\026\f\021\026\017\030\024\r\026\027\017\016 \ )Tj 0.032 Tw T* (\024\023\031\b\024\035\017 \r)Tj /Span<>> BDC ( )Tj EMC (\035\017\n\235\026\021\017\004\036\f\022\017\036 \031\035\t \017)Tj /Span<>> BDC ( )Tj EMC (\030\036\022\024\n\036\027\007\024\r\026\027\026 \022\026\022 )Tj 0.43 Tw T* (\024\002\016\026\021\036\035\034\027\t\005 \n\024\030\235\024\035\024\020\ \017\004\036\f\022\017\005 \023\030\017\027\026\022 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\017\f)Tj 0 Tw (-)Tj 0.225 Tw T* [(\f\035\036\007\024\r\026\027\017\017 )0.6(\024\002\030\026\006\024\r )0.5(\024\023\031\b\024\035\017. )0.6(\200)]TJ /Span<>> BDC ( )Tj EMC 14.793 0 Td [(\027\026\f\021\024\016\013\036\036 )0.6(\r\030\036\n\016 )]TJ 0.445 Tw -14.793 -1.218 Td (\r)Tj /Span<>> BDC ( )Tj EMC 1.151 0 Td [(\023\030\024\r\036\007\036\027\027\t\b )0.5(\017\f\f\035\036\007\024\r\026\027\017\016\b )0.5(\035\017\n\235\024\r\026\f\022\031\035\016\030\027\026\016 )]TJ 0.3 Tw -1.151 -1.218 Td [(\017\027\r\026\017\016 \023\024\022\026\026\035\026 )0.5(\f\r\024\036 \027\026\004\017\n\024\036 \023\030\024\020\027\024\f\021\017\ \004\036\f\022\017\036 )]TJ 0.151 Tw T* [(\027\026\004\036\027\017\036 )0.6(\022\026\022 )0.5(\023\030\036\007\017\022\021\024\030 )0.5(\n\036\021\026\f\021\026\017\030\024\r\026\027\017\016 )0.6(\023\030\017)]TJ /Span<>> BDC ( )Tj EMC 20.529 0 Td (\025\217\217 )Tj 0.223 Tw -20.529 -1.218 Td (\2301 [7,18,22,23,43,64\22669]. \200)Tj /Span<>> BDC ( )Tj EMC (\021\024\032\036 \r\030\036\n\016, \r)Tj /Span<>> BDC ( )Tj EMC (\030\016\007\036 \017\f)Tj 0 Tw (-)Tj 0.024 Tw T* [(\f\035\036\007\024\r\026\027\017\005, \027\026\030\016\007\031 )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC (\027\036\026\r\017\f\017\n\t\n \023\030\024\020\027\024\f\021\017\004\036\ \f\022\017\n )Tj 0.11 Tw T* (\027\026\004\036\027\017\036\n \007\026\027\027\024\020\024 \023\030\017\ \027\026\022\026 \024\021\n\036\004\026\036\021\f\016 \036\020\024 \027\ \017\022\026\016 )Tj 0.187 Tw T* (\r\024\f\023\030\024\017\r\024\007\017\n\024\f\021\034 \f\030\036\007\017\ \023\026\021\024\035\024\020\024\r. \212\026\027\027\026\016 \023\030\024\ \002)Tj 0 Tw (-)Tj -0.01 Tw T* (\035\036\n\026 \024\002\024\027\026\004\036\027\026 \r)Tj /Span<>> BDC ( )Tj EMC [(\017\f\f\035\036\007\024\r\026\027\017\016\b W)12(ad)42(a \017)]TJ /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. [43], )Tj 0.055 Tw T* [(Har)-24(r)-36.9(is)]TJ /Span<>> BDC ( )Tj EMC [(E. [66], K)25(ojima)]TJ /Span<>> BDC ( )Tj EMC (M. [72]. \217\036\031\035\034\021\026\021\t \017\f\f\035\036\007\024\r\026\ )Tj 0 Tw (-)Tj 0.211 Tw T* [(\027\017\005 )0.5(\024\021\027\024\f\017\021\036\035\034\027\024 )0.6(\r\024\f\023\030\024\017\r\024\007\017\n\024\f\021\017 )0.6(\035\017\n\235\024\r\026\f\022\031)]TJ 0 Tw (-)Tj -0.048 Tw T* (\035\016\030\027\024\005 \017\027\r\026\017\017 \f\030\036\007\017 \023\ \026\021\024\035\024\020\024\r \023\024\022\026\t\r\026\033\021 \007\024\ \r\024\035\034)Tj 0 Tw (-)Tj 0.001 Tw T* (\027\024 \027\017\022\017\036 \027\026\004\036\027\017\016 \022\024\220\ \235\235\017\006\017\036\027\021\026 \022\026\023\023\026: \023\024)Tj /Span<>> BDC ( )Tj EMC (\007\026\027\027\t\n )Tj 0.028 Tw T* [(Har)-24(r)-36.9(is \017)]TJ /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. [66] \024\027 \f\024\f\021\026\r\035\016\036\021 0,28 \ \()Tj /T1_1 1 Tf 0 Tw (k)Tj /T1_0 1 Tf 0.028 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,28; 95% )Tj 0.125 Tw T* (CI: 0,22\2260,34\) \017)Tj /Span<>> BDC ( )Tj EMC (\027\036 \031\035\031\004\001\026\036\021\f\016 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\023\030\017\n\036\027\036\027\017\017 \007\024)Tj 0 Tw (-)Tj 0.727 Tw T* (\023\024\035\027\017\021\036\035\034\027\024\020\024 \017\n\n\031\027\024\ \020\017\f\021\024\b\017\n\017\004\036\f\022\024\020\024 \024\022\030\026\ \001\017)Tj 0 Tw (-)Tj 0.188 Tw T* (\r\026\027\017\016 \f\030\036\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\026\027\021\017\021\036\035\026\n\017 \022)Tj /Span<>> BDC ( )Tj EMC (\224\212 31 \()Tj /T1_1 1 Tf 0 Tw (k)Tj /T1_0 1 Tf 0.188 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,26, 95% )Tj 0.108 Tw T* (CI: 0,10\2260,42\) \017)Tj /Span<>> BDC ( )Tj EMC (D2-40 \()Tj /T1_1 1 Tf 0 Tw (k)Tj /T1_0 1 Tf 0.108 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,32, 95% CI: 0,21\2260,42\). )Tj 0.166 Tw T* (\200)Tj /Span<>> BDC ( )Tj EMC (\021\024\032\036 \r\030\036\n\016, \030\036\031\035\034\021\026\021\t \007\ \030\031\020\017\b \017\f\f\035\036\007\024\r\026\027\017\005 \007\036)Tj 0 Tw (-)Tj 0.022 Tw T* [(\n\024\027\f\021\030\017\030\031\033\021, \004\021\024 \023\030\017\n\036\ \027\036\027\017\036 )0.5(\007\024\023\024\035\027\017\021\036\035\034\027\t\b \n\036\021\024)]TJ 0 Tw (-)Tj 0.125 Tw T* [(\007\017\022 )0.5(\007\035\016 )0.5(\r\t\016\r\035\036\027\017\016 )0.5(\035\017\n\235\024\r\026\f\022\031\035\016\030\027\024\005 )0.6(\017\027\r\026\017\017 )0.5(\017\035\017 )]TJ 0.191 Tw T* (\f\036\035\036\022\021\017\r\027\024\005 \024\022\030\026\f\022\017 \035\ \017\n\235\026\021\017\004\036\f\022\017\b \f\024\f\031\007\024\r \031\035\ \031\004)Tj 0 Tw (-)Tj 0.14 Tw T* (\001\026\036\021 \r\024\f\023\030\024\017\r\024\007\017\n\024\f\021\034\ \220\021\024\020\024 \023\030\017\027\026\022\026 \017)Tj /Span<>> BDC ( )Tj EMC (\036\020\024 \023\030\036)Tj 0 Tw (-)Tj 0.01 Tw T* (\007\017\022\021\017\r\027\024\036 \027\026\004\036\027\017\036 [71\226\ 73]. \215\024)Tj /Span<>> BDC ( )Tj EMC [(\007\026\027\027\t\n W)12(a)15(t)15(anabe)]TJ /Span<>> BDC ( )Tj EMC (J. )Tj 0.14 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. [74], \023\030\017\n\036\027\036\027\017\036 \007\024\023\ \024\035\027\017\021\036\035\034\027\t\b \n\036\021\024\007\024\r )Tj 0.65 Tw T* (\024\022\030\026\001\017\r\026\027\017\016 \007\035\016 \r\t\016\r\035\036\ \027\017\016 \035\017\n\235\024\r\026\f\022\031\035\016\030\027\024\005 \ )Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0 Tw 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\206)10(\002\036\033 \035\030\032\003\033)30(\n)42(\032)-21(\230\033\241)]TJ 57.136 0 Td (REVIEW)Tj -57.136 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 2)69(4, \023\0224, 202)23(5)]TJ 43.013 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 2)69(4, \023\0224, 202)23(5)]TJ /T1_3 1 Tf 25 0 0 25 20.7902 56.0378 Tm (182)Tj ET endstream endobj 1009 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\034\201\025\235\t\016\024\220 \021\022\222\016\201\b\222\016\017)-9.9(\026\021\r\220 \222\201\021\024\016\215\016\215\021\004 \024\025\201\223\ \025\t\025\202\021\f\016\b\017\021 )]TJ 0 -1 TD [(\223\001\017)-10(\026)11(\025\201\025\r \201\021\b\017\001 \024\016\026)11(\001\b)-10(\026)11(\001\213\021\201\025\r\001\215\021\004 \r\022\t\021\024\223\001\026\021\f\ \016\b\017\021\016 \200)31(\213\t\220 )]TJ T* [(\222\201\021\022\017)10(\025\t\025\201\016\017)-10(\026)11(\001\t\214\215\025\024 \201\001\017\016 \0321 \(\025\235\213\025\201 \t\021\ \026)11(\016\201\001\026)-20(\200\201\220\))]TJ 37.237 2 Td [(Pr)20(oblems and pr)20(ospects of\022using morph)11(ological risk factor)20.1(s )]TJ 0.243 -1 Td [(for\022lymph node metastasis in T1 color)31(ectal cancer \(r)31(e)11(vie)11(w\))]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0.003 Tw 10 0 0 10 42.5197 724.8299 Tm [(\f\030\036\007\017 \023\026\021\024\035\024\020\024\r, \004\036\n \020\035\ \031\002\017\027\026, )0.5(\f\024 \027\026\004\036\027\017\036\n )0.5(\022\024\220\235\235\017)]TJ 0 Tw (-)Tj 0.012 Tw 0 -1.218 TD (\006\017\036\027\021\026 \025\024\220\027\026 )Tj /T1_2 1 Tf 0 Tw (k)Tj /T1_1 1 Tf 0.012 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,41, \r)Tj /Span<>> BDC ( )Tj EMC (\021\024 \r\030\036\n\016 \022\026\022 \r)Tj /Span<>> BDC ( )Tj EMC (\017\f\f\035\036\007\024\r\026\027\017\017 )Tj -0.057 Tw T* [(W)12(ang)]TJ /Span<>> BDC ( )Tj EMC (L.M. \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. [41] \f\030\026\r\027\036\027\017\036 \n\036\021\024\007\ \017\022 \017\n\036\030\036\027\017\016 )Tj 0.145 Tw T* (\020\035\031\002\017\027\t \017)Tj /Span<>> BDC ( )Tj EMC (\001\017\030\017\027\t \023\024\007\f\035\017\017\f\021\024\005 \017\027\ \r\026\017\017 \023\024\022\026\026\035\024 )Tj 0.002 Tw T* [(\b\031\007\001\031\033 \022\024\027\022\024\030\007\026\027\021\027\024\f\ \021\034 )0.5(\030\036\031\035\034\021\026\021\024\r \017\n\036\030\036\027\017\016 \ \001\017)]TJ 0 Tw (-)Tj 0.037 Tw T* (\030\017\027\t \023\024\007\f\035\017\017\f\021\024\005 \017\027\r\026\ \017\017 \()Tj /T1_2 1 Tf 0 Tw (k)Tj /T1_1 1 Tf 0.037 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,37\) \023\024)Tj /Span<>> BDC ( )Tj EMC (\f\030\026\r\027\036\027\017\033 )Tj 0 Tw 0 -1.218 TD (\f)Tj /Span<>> BDC ( )Tj EMC (\024\006\036\027\022\024\005 \020\035\031\002\017\027\t \023\024\007\f\035\ \017\017\f\021\024\005 \017\027\r\026\017\017 \()Tj /T1_2 1 Tf (k)Tj /T1_1 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,67\).)Tj 0.004 Tc 0.081 Tw 0 -1.218 TD (\236\031\004\036\027\017\036 \023\030\024\020\027\024\f\021\017\004\036\ \f\022\024\020\024 \027\026\004\036\027\017\016 \023\035\024\013\026\007\ \017 \023\024\007)Tj 0 Tc 0 Tw (-)Tj 0.004 Tc 0.106 Tw T* (\f\035\017\017\f\021\024\005 \017\027\r\026\017\017 \r)Tj /Span<>> BDC ( )Tj EMC [(\017\f\f\035\036\007\024\r\026\027\017\016\b Suzuk)-16(i)]TJ /Span<>> BDC ( )Tj EMC (T. \017)Tj /Span<>> BDC ( )Tj EMC (\f\024)Tj 0 Tc 0 Tw (-)Tj 0.004 Tc 0.227 Tw T* [(\026\r\021. \(2003\) [35], Egashir)-32.9(a Y. \017)]TJ /Span<>> BDC ( )Tj EMC [(\f\024\026\r\021. \(2004\) [40],)4( )]TJ -0.025 Tw T* [(T)45(oh)]TJ /Span<>> BDC ( )Tj EMC 1.659 0 Td [(E. )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC [(\f\024\026\r\021. \(2015\) )0.5([39], )0.5(Y)-29(im)]TJ /Span<>> BDC ( )Tj EMC [(K. )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 13.15 0 Td [(\f\024\026\r\021.\(2017\) )0.5([37])4( )]TJ 0.03 Tw -14.809 -1.218 Td (\023\024\022\026\026\035\024 \r\026\017\n\024\f\r\016\034 \007\026\027\ \027\024\020\024 \023\026\030\026\n\036\021\030\026 \f)Tj /Span<>> BDC ( )Tj EMC (\n\036\021\026\f\021\026)Tj 0 Tc 0 Tw (-)Tj 0.004 Tc 0.086 Tw 0 -1.218 TD (\026\n\017 \r)Tj /Span<>> BDC ( )Tj EMC [(\035\017\n\235\024\031\035\026\b. T)45(oh)]TJ /Span<>> BDC ( )Tj EMC (E. \017)Tj /Span<>> BDC ( )Tj EMC [(Y)-29(im)]TJ /Span<>> BDC ( )Tj EMC [(K. \024\021\n\036\004\026\035\017 \002\024\035\036\036)4( )]TJ 0.462 Tw 0 -1.218 TD (\021\024\004\027\024\036 \023\030\024\020\027\024\f\021\017\004\036\f\022\ \024\036 \027\026\004\036\027\017\036 \023\035\024\013\026\007\017 \023\ \024\007)Tj 0 Tc 0 Tw (-)Tj 0.004 Tc 0.201 Tw 0 -1.218 TD (\f\035\017\017\f\021\024\005 \017\027\r\026\017\017, \004\036\n \036\036\ \020\035\031\002\017\027\026. \224\035\036\007\031\036\021 \024\021\n\036\ )Tj 0 Tc 0 Tw (-)Tj 0.004 Tc 0.092 Tw T* (\021\017\021\034, \004\021\024 \r)Tj /Span<>> BDC ( )Tj EMC [(\023\030\024\r\036\007\036\027\027\t\b \017\f\f\035\036\007\024\r\026\027\ \017\016\b \021\026\022\032\036 \002\t\035\017)4( )]TJ 0.168 Tw T* [(\023\024\035\031\004\036\027\t \030\026\035\017\004\027\t\036 \023\024\030\ \024\020\024\r\t\036 \027\026\004\036\027\017\016 \023\035\024\013\026\007\ \017)4( )]TJ 0.151 Tw T* (\023\024\007\f\035\017\017\f\021\024\005 \017\027\r\026\017\017 \026\007\ \036\027\024\022\026\030\006\017\027\024\n\t \f)Tj /Span<>> BDC ( )Tj EMC [(\001\017\030\024\022\017\n)4( )]TJ 0.091 Tw T* (\022\024\035\036\002\026\027\017\036\n \r\036\035\017\004\017\027 \024\021\ 6,5 \007\024)Tj /Span<>> BDC ( )Tj EMC (35 \n\n)Tj 0 Tc 0 Tw 5.83 0 0 5.83 199.0549 508.9558 Tm (2)Tj 0.004 Tc 0.091 Tw 10 0 0 10 201.9932 505.6258 Tm [(. \215\030\024\r\036\007\036\027\027\024\036)4( )]TJ 0.441 Tw -15.947 -1.218 Td (\017\f\f\035\036\007\024\r\026\027\017\036 \027\026)Tj /Span<>> BDC ( )Tj EMC (\027\026\004\017\021\036\035\034\027\024\n \022\035\017\027\017\004\036\ \f\022\024\n \n\026)Tj 0 Tc 0 Tw (-)Tj 0.004 Tc 0.267 Tw T* [(\021\036\030\017\026\035\036 \024\023\031\b\024\035\036\005 \030\2301, \031\ \007\026\035\036\027\027\t\b \023\031\021\036\n \030\036\036\022\006\017\ \017)4.1( )]TJ 0.133 Tw T* [(\023\030\016\n\024\005 \017\035\017 \024\002\024\007\024\004\027\024\005\ \022\017\001\022\017, \023\024\022\026\026\035\024 \024\021\f\031\021\f\ \021\r\017\036)3.9( )]TJ 0.242 Tw T* [(\027\026\004\017\n\024\005 \r\026\017\n\024\f\r\016\017 \n\036\032\007\ \031 \n\024\030\235\024\n\036\021\030\017\004\036\f\022\017\n\017)4( )]TJ 0.383 Tw T* [(\(\020\035\031\002\017\027\026, \001\017\030\017\027\026, \023\035\024\013\ \026\007\034 \017\027\r\026\017\017\) \022\030\017\021\036\030\017\016\n\ \017)4( )]TJ 0.121 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC 0.879 0 Td [(\004\026\f\021\024\021\024\005 )0.5(\024\002\027\026\030\031\032\036\027\017\016 )0.5(\n\036\021\026\f\021\026\024\r )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 15.787 0 Td [(\030\036\020\017\024\027\026\030\027\t\b)4.1( )]TJ 0 Tw -16.666 -1.218 Td (\035\017\n\235\024\031\035\026\b)Tj /Span<>> BDC ( )Tj EMC ([42].)Tj 0 Tc 0.445 Tw T* [(\210\021\027\024\f\017\021\036\035\034\027\024 )0.6(\023\030\026\022\021\017\004\036\f\022\024\020\024 )0.6(\023\030\017\n\036\027\036\027\017\016 )0.6(\001\017\030\017\027\t )]TJ 0.196 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\023\035\024\013\026\007\017 \023\024\007\f\035\017\017\f\021\024\005 \017\ \027\r\026\017\017 \022\026\022 \023\030\036\007\017\022\021\024\030\024\ \r )Tj -0.006 Tw T* (\n\036\021\026\f\021\026\017\030\024\r\026\027\017\016, \r\026\032\027\t\ \n \031\f\035\024\r\017\036\n \016\r\035\016\036\021\f\016 \021\024, \004\ \021\024 )Tj -0.035 Tw T* (\017\b \021\024\004\027\024\036 \017)Tj /Span<>> BDC ( )Tj EMC (\024\002\255\036\022\021\017\r\027\024\036 \017\n\036\030\036\027\017\036\ \r\024\n\024\032\027\024 \021\024\035\034\022\024 )Tj 0.087 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\017\f\023\024\035\034\024\r\026\027\017\036 \006\017\235\030\024\r\024\ \005 \023\026\021\024\035\024\020\017\017 \(\017\031\004\036\027\017\036\ \020\017)Tj 0 Tw (-)Tj 0.136 Tw T* [(\f\021\024\f\022\026\027\024\r\) )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 5.788 0 Td [(\022\024\n\023\034\033\021\036\030\027\t\b )0.6(\021\036\b\027\024\035\024\020\017\005 )0.6(\023\030\017)]TJ /Span<>> BDC ( )Tj EMC 13.377 0 Td (\f\024\002\035\033)Tj 0 Tw (-)Tj 0.041 Tw -19.165 -1.218 Td (\007\036\027\017\017 \f\024\024\021\r\036\021\f\021\r\031\033\013\017\b \ \023\030\024\021\024\022\024\035\024\r \023\026\021\024\n\024\030\235\024\ \035\024\020\017)Tj 0 Tw (-)Tj T* (\004\036\f\022\024\020\024 \017\f\f\035\036\007\024\r\026\027\017\016.)Tj 0.087 Tw T* (\230\026\022\017\n \024\002\030\026\024\n, \030\036\031\035\034\021\026\ \021\t \023\030\024\r\036\007\036\027\027\t\b \017\f\f\035\036\007\024\r\ \026)Tj 0 Tw (-)Tj 0.047 Tw T* (\027\017\005 \024\021\027\024\f\017\021\036\035\034\027\024 \023\030\024\ \020\027\024\f\021\017\004\036\f\022\024\020\024 \027\026\004\036\027\017\ \016 \001\017\030\017)Tj 0 Tw (-)Tj 0.031 Tw T* (\027\t \017)Tj /Span<>> BDC ( )Tj EMC (\023\035\024\013\026\007\017 \023\024\007\f\035\017\017\f\021\024\005 \017\ \027\r\026\017\017 \007\036\n\024\027\f\021\030\017\030\031\033\021 )Tj 0.147 Tw T* [(\001\017\030\024\022\017\005 )0.5(\007\017\026\023\026\024\027 )0.6(\023\024\030\024\020\024\r\t\b )0.5(\027\026\004\036\027\017\005 )0.6(\007\026\027\027\t\b )0.6(\023\026)]TJ 0 Tw (-)Tj 0.156 Tw T* (\030\026\n\036\021\030\024\r, \023\024\035\031\004\036\027\027\t\b \r)Tj /Span<>> BDC ( )Tj EMC (\030\026\027\t\b \017\f\f\035\036\007\024\r\026\027\017\016\b, \004\021\ \024 )Tj 0.166 Tw T* (\027\036 \023\024\r\024\035\016\036\021 \023\030\017\n\036\027\016\021\034\ \007\026\027\027\t\036 \022\030\017\021\036\030\017\017 \027\026)Tj /Span<>> BDC ( )Tj EMC (\023\030\026\022)Tj 0 Tw (-)Tj 0.033 Tw T* (\021\017\022\036 \r)Tj /Span<>> BDC ( )Tj EMC (\027\026\f\021\024\016\013\036\036 \r\030\036\n\016. \025\026\022 \017)Tj /Span<>> BDC ( )Tj EMC (\n\027\024\020\017\036 \023\030\036\007\035\026\020\026\036\n\t\036 )Tj 0.278 Tw T* [(\027\024\r\t\036 )0.5(\022\030\017\021\036\030\017\017, )0.6(\024\027\017 )0.5(\021\030\036\002\031\033\021 )0.5(\007\026\035\034\027\036\005\001\036\020\024 )0.6(\017\031\004\036)]TJ 0 Tw (-)Tj 0.118 Tw T* (\027\017\016 \017)Tj /Span<>> BDC ( )Tj EMC (\r\026\035\017\007\026\006\017\017 \027\026)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\034\001\036\n \022\024\035\017\004\036\f\021\r\036 \n\026\021\ \036\030\017\026\035\026 )Tj 0 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\024\023\030\036\007\036\035\036\027\017\036\n \036\007\017\027\024\005 \ \023\024\030\024\020\024\r\024\005 \r\036\035\017\004\017\027\t.)Tj 0.42 Tw T* (\210\021\027\024\f\017\021\036\035\034\027\024 \020\017\f\021\024\035\024\ \020\017\004\036\f\022\017\b \023\026\030\026\n\036\021\030\024\r \026\007\ \036\027\024)Tj 0 Tw (-)Tj 0.72 Tw T* (\022\026\030\006\017\027\024\n\t, \022\026\022 \023\030\036\007\017\022\021\ \024\030\024\r \n\036\021\026\f\021\026\017\030\024\r\026\027\017\016, \ )Tj 0.836 Tw T* [(\f\030\036\007\017 )0.5(\017\f\f\035\036\007\024\r\026\021\036\035\036\005 )0.5(\024\021\n\036\004\026\036\021\f\016 )0.6(\f\031\013\036\f\021\r\036\027\027\024 )]TJ 0.427 Tw T* (\002\024\035\034\001\017\005 \022\024\027\f\036\027\f\031\f. \210\f\027\024\ \r\027\026\016 \007\017\f\022\031\f\f\017\016 \024\021\027\024\f\017)Tj 0 Tw (-)Tj 0.088 Tw T* (\021\036\035\034\027\024 \017\b \023\030\017\n\036\027\036\027\017\016, \ \022\026\022 \235\026\022\021\024\030\024\r \030\017\f\022\026 \n\036\021\ \026\f\021\026)Tj 0 Tw (-)Tj 0.228 Tw T* (\017\030\024\r\026\027\017\016, \022\026\f\026\036\021\f\016 \022\030\017\ \021\036\030\017\036\r \024\023\030\036\007\036\035\036\027\017\016 \017\ , \f\024)Tj 0 Tw (-)Tj 0.205 Tw T* (\024\021\r\036\021\f\021\r\036\027\027\024, \r\024\f\023\030\024\017\r\024\ \007\017\n\024\f\021\017 \f\030\036\007\017 \023\026\021\024\035\024\020\ \024\r. )Tj 0.996 Tw T* (\200\024\f\023\030\024\017\r\024\007\017\n\024\f\021\034 \020\017\f\021\ \024\035\024\020\017\004\036\f\022\017\b \023\030\017\027\026\022\024\r\ , )Tj 0.36 Tw T* (\022\026\022 \023\030\026\r\017\035\024, \024\023\030\036\007\036\035\016\ \036\021\f\016 \022\024\220\235\235\017\006\017\036\027\021\024\n \022\026\ \023\023\026 )Tj 0.149 Tw T* (\025\024\220\027\026, \022\024\021\024\030\t\005 \023\030\036\007\f\021\026\ \r\035\016\036\021 \f\024\002\024\005 \f\021\026\021\017\f\021\017\004\036\ \f\022\031\033 )Tj 0.039 Tw 23.244 64.543 Td (\n\036\021\030\017\022\031, \024\023\030\036\007\036\035\016\033\013\031\ \033 \031\030\024\r\036\027\034 \f\024\020\035\026\f\017\016 \023\030\017\ )Tj /Span<>> BDC ( )Tj EMC (\024\006\036\027)Tj 0 Tw (-)Tj T* (\022\036 \024\023\030\036\007\036\035\036\027\027\t\b \023\026\030\026\n\ \036\021\030\024\r.)Tj /T1_2 1 Tf 0.257 Tw 0 -2.436 TD (\n\022\017\017\016\033\016\020\007\022\033\034\036\021\037 \037\b\016\020\ \034\021\037\033\007\022\020\034\006\032/\024\035\016\f\016\020\003 \031\ \027\034\021\037)Tj 0 Tw (-)Tj 0 -1.218 TD (\005\016\024\035\036\016\020\020\034\024\035\022 \037\b\016\020\034\021\037\ \033\007\022\020\034\006\032)Tj /T1_1 1 Tf 0.533 Tw T* (\003\027\026\004\036\027\017\036 \027\017\022\024\005 \007\017\235\235\036\ \030\036\027\006\017\030\024\r\022\017 \026\007\036\027\024\022\026\030\006\ \017)Tj 0 Tw (-)Tj 0.171 Tw 0 -1.218 TD (\027\024\n\t \022\026\022 \027\036\002\035\026\020\024\023\030\017\016\021\ \027\024\020\024 \023\030\024\020\027\024\f\021\017\004\036\f\022\024\020\ \024 \235\026\022)Tj 0 Tw (-)Tj 0.092 Tw 0 -1.218 TD (\021\024\030\026 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\025\217\217 \2301 \023\024\022\026\026\027\024 \r\024 \n\027\024\020\017\ \b \017\f\f\035\036\007\024\r\026\027\017\016\b )Tj -0.084 Tw T* ([6,7,18,21,22,26,38,43]. \205\026\022\021\024\030\026\n\017 \030\017\f\022\ \026 \n\036\021\026\f\021\026\017\030\024)Tj 0 Tw (-)Tj -0.016 Tw T* [(\r\026\027\017\016 )0.5(\021\026\022\032\036 )0.5(\f\004\017\021\026\033\021\f\016 )0.5(\024\f\024\002\t\036 )0.5(\020\017\f\021\024\035\024\020\017\004\036\f\022\017\036 )0.6(\021\017\023\t )]TJ 0.136 Tw T* (\022\026\030\006\017\027\024\n\t, \021\026\022\017\036 \022\026\022 \n\031\ \006\017\027\024\027\t\005 \017)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\f\021\027\036\r\017\007\027\024)Tj 0 Tw (-)Tj 0.034 Tw T* (\022\035\036\021\024\004\027\t\005 \030\026\022\017, \026)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\032\036 \n\036\007\031\035\035\016\030\027\t\005 \030\026\022\ , \024\f\024\002\036\027\027\024 )Tj -0.052 Tw 0 -1.218 TD (\f)Tj /Span<>> BDC ( )Tj EMC (\f\024\b\030\026\027\036\027\017\036\n \235\031\027\022\006\017\017 \f\017\ \f\021\036\n\t \002\036\035\022\024\r MMR \(pMMR\). )Tj -0.027 Tw 0 -1.218 TD (\224\004\017\021\026\036\021\f\016, \004\021\024 \r\026\030\017\026\027\021\ \t \021\026\022\017\b \022\026\030\006\017\027\024\n \f)Tj /Span<>> BDC ( )Tj EMC (\007\036\235\017\006\017\021\024\n )Tj 0.1 Tw 0 -1.218 TD (\002\036\035\022\024\r \f\017\f\021\036\n\t MMR \(dMMR\) \017\n\036\033\021\ \035\031\004\001\036\036 \023\030\024\020\027\024)Tj 0 Tw (-)Tj -0.014 Tw T* (\f\021\017\004\036\f\022\024\036 \027\026\004\036\027\017\036, \024\007\ \027\026\022\024 \007\026\027\027\t\036 \030\036\031\035\034\021\026\021\ \t \023\024\035\031)Tj 0 Tw (-)Tj 0.137 Tw T* (\004\036\027\t \027\026)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\036\036 \030\026\f\023\030\024\f\021\030\026\027\201\027\027\ \t\b \f\021\026\007\017\016\b \024\023\031\b\024\035\036\005 )Tj 0.163 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\027\036 \017\n\036\033\021 \007\024\f\021\026\021\024\004\027\024\020\024\ \023\024\007\021\r\036\030\032\007\036\027\017\016 \r)Tj /Span<>> BDC ( )Tj EMC (\f\035\031\004\026\016\b )Tj 0.178 Tw T* [(\025\217\217 )0.5(\2301 )0.5([44,45,46]. )0.6(\200)]TJ /Span<>> BDC ( )Tj EMC 9.136 0 Td [(\027\026\f\021\024\016\013\036\036 )0.5(\r\030\036\n\016 )0.5(\027\017\022\026\016 )0.5(\007\017\235)]TJ 0 Tw (-)Tj 0.296 Tw -9.136 -1.218 Td (\235\036\030\036\027\006\017\030\024\r\022\026 \024\023\031\b\024\035\017\ \030\026\f\f\n\026\021\030\017\r\026\036\021\f\016 \022\026\022 \027\036\ \026)Tj 0 Tw (-)Tj 0.009 Tw T* [(\r\017\f\017\n\t\005 \023\030\024\020\027\024\f\021\017\004\036\f\022\017\ \005 )0.5(\235\026\022\021\024\030, \024\023\030\036\007\036\035\016\033\013\017\005\ )0.5(\027\036 )]TJ 0.13 Tw T* [(\021\024\035\034\022\024 )0.5(\030\017\f\022 )0.5(\n\036\021\026\f\021\026\017\030\024\r\026\027\017\016 )0.5(\024\023\031\b\024\035\017, )0.5(\027\024 \017)]TJ /Span<>> BDC ( )Tj EMC 19.492 0 Td (\r\t\032\017)Tj 0 Tw (-)Tj 0.065 Tw -19.492 -1.218 Td (\r\026\036\n\024\f\021\034 \023\026\006\017\036\027\021\024\r [9,12,14,1\ 5]. \215\030\017)Tj /Span<>> BDC ( )Tj EMC (\f\031\013\036\f\021\r\031\033\013\036\n )Tj 0.335 Tw T* (\022\024\027\f\036\027\f\031\f\036 \024\021\027\024\f\017\021\036\035\034\ \027\024 \023\030\024\020\027\024\f\021\017\004\036\f\022\024\020\024 \027\ \026\004\036)Tj 0 Tw (-)Tj 0.201 Tw T* (\027\017\016 \007\026\027\027\024\020\024 \023\030\017\027\026\022\026 \ \017\n\036\033\021\f\016 \024\023\030\036\007\036\035\036\027\027\t\036 \ \030\026)Tj 0 Tw (-)Tj 0.026 Tw T* [(\035\017\004\017\016 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC [(\022\030\017\021\036\030\017\016\b )0.5(\036\020\024 \024\006\036\027\022\017 \017)]TJ /Span<>> BDC ( )Tj EMC (\r\024\f\023\030\024\017\r\024\007\017\n\024\f\021\017. )Tj 0.202 Tw T* [(\210\023\030\036\007\036\035\036\027\027\t\005 )0.5(\f\031\002\255\036\022\021\017\r\017\n \023\026\021\024\035\024\020\024\ \r \023\030\017)]TJ /Span<>> BDC ( )Tj EMC (\024\006\036\027\022\036 )Tj 0.066 Tw T* (\007\017\235\235\036\030\036\027\006\017\030\024\r\022\017 \022\024\035\024\ \030\036\022\021\026\035\034\027\024\005 \026\007\036\027\024\022\026\030\ \006\017\027\024\n\t )Tj 0.002 Tw T* (\023\030\017\r\024\007\017\021 \022)Tj /Span<>> BDC ( )Tj EMC (\027\026\004\017\021\036\035\034\027\t\n \030\026\f\b\024\032\007\036\027\ \017\016\n \r)Tj /Span<>> BDC ( )Tj EMC (\024\023\030\036\007\036\035\036)Tj 0 Tw (-)Tj 0.088 Tw T* (\027\017\017 \007\026\027\027\024\020\024 \023\030\017\027\026\022\026 \ \027\026)Tj /Span<>> BDC ( )Tj EMC [(\023\030\026\022\021\017\022\036. K)25(omut)15(a \017)]TJ /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. )Tj -0.002 Tw T* [([47] \023\030\017\r\024\007\017\021 )0.5(\007\026\027\027\t\036, \004\021\024 )0.5(\023\030\017)]TJ /Span<>> BDC ( )Tj EMC [(\031\f\021\026\027\024\r\035\036\027\017\017 )0.5(\f\021\036\023\036\027\017 )]TJ 0.119 Tw T* (\007\017\235\235\036\030\036\027\006\017\030\024\r\022\017 \024\023\031\b\ \024\035\017 \(\r\t\f\024\022\024- \017\035\017 \031\n\036\030\036\027\027\ \024)Tj 0 Tw (-)Tj 0.98 Tw T* (\007\017\235\235\036\030\036\027\006\017\030\024\r\026\027\027\026\016 \026\ \007\036\027\024\022\026\030\006\017\027\024\n\026\) \023\024\022\026\026\ )Tj 0 Tw (-)Tj 0.261 Tw T* [(\021\036\035\034 )0.5(\f\024\020\035\026\f\017\016 )0.6(\(\022\024\220\235\235\017\006\017\036\027\021 )]TJ /T1_2 1 Tf 0 Tw 12.923 0 Td (k)Tj /T1_1 1 Tf 0.261 Tw [(\) )0.5(\n\036\032\007\031 )0.5(\023\026\021\024\035\024\020\026\n\017 )]TJ 0.256 Tw -12.923 -1.218 Td (\023\024)Tj /Span<>> BDC ( )Tj EMC (\007\026\027\027\024\n\031 \023\030\017\027\026\022\031 \007\026\032\036\ \f\030\036\007\017 \024\023\t\021\027\t\b \f\023\036\006\017)Tj 0 Tw (-)Tj 0.035 Tw T* (\026\035\017\f\021\024\r \002\t\035 \024\004\036\027\034 \027\017\022\017\ \n \017)Tj /Span<>> BDC ( )Tj EMC (\030\026\r\027\016\035\f\016 0,163. \215\024)Tj /Span<>> BDC ( )Tj EMC (\007\026\027)Tj 0 Tw (-)Tj 0.054 Tw T* [(\027\t\n Daven)11(por)-21.9(t)]TJ /Span<>> BDC ( )Tj EMC (A. [34], \017\031\004\036\027\017\036 \r\024\f\023\030\024\017\r\024\007\ \017\n\024\f\021\017 )Tj -0.004 Tw T* (\007\026\027\027\024\020\024 \023\030\017\027\026\022\026 \f)Tj /Span<>> BDC ( )Tj EMC (\024\023\030\036\007\036\035\036\027\017\036\n \022\024\220\235\235\017\006\ \017\036\027\021\026 \f\024)Tj 0 Tw (-)Tj 0.026 Tw T* (\020\035\026\f\017\016 \n\036\032\007\031 \023\026\021\024\035\024\020\026\ \n\017 \r)Tj /Span<>> BDC ( )Tj EMC (\030\026\n\022\026\b \002\030\017\021\026\027\f\022\024\005 \f\022\030\017\ )Tj 0 Tw (-)Tj 0.448 Tw T* [(\027\017\027\020\024\r\024\005 )0.6(\023\030\024\020\030\026\n\n\t )0.5(UK )0.5(Bo)-14(wel )0.6(Cancer )0.5(S)-24(cr)-24(eening )]TJ 0.11 Tw T* [(P)35(r)-32(o)-16(gr)-33(amme \(BCSP\) \023\024\022\026\026\035\024 \024\004\036\027\034 \027\017\ \022\017\005 \030\036\031\035\034\021\026\021 )]TJ 0.097 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\r\036\035\017\004\017\027\024\005 )Tj /T1_2 1 Tf 0 Tw (k)Tj /T1_1 1 Tf 0.097 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,07. \200)Tj /Span<>> BDC ( )Tj EMC (\f\035\031\004\026\016\b \007\017\235\235\036\030\036\027\006\017\026\035\ \034\027\024\005 )Tj 0.106 Tw T* (\007\017\026\020\027\024\f\021\017\022\017 \n\036\032\007\031 \r\t\f\024\ \022\024- \017)Tj /Span<>> BDC ( )Tj EMC (\027\017\022\024\007\017\235\235\036\030\036\027\006\017\030\024)Tj 0 Tw (-)Tj -0.006 Tw T* (\r\026\027\027\t\n\017 \026\007\036\027\024\022\026\030\006\017\027\024\n\ \026\n\017 \220\021\024\021 \023\024\022\026\026\021\036\035\034, \023\024\ )Tj /Span<>> BDC ( )Tj EMC (\007\026\027)Tj 0 Tw (-)Tj 0.055 Tw T* (\027\t\n Ueno)Tj /Span<>> BDC ( )Tj EMC (H. \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. [48] \017)Tj /Span<>> BDC ( )Tj EMC [(Y)40(oshid)42(a)]TJ /Span<>> BDC ( )Tj EMC (N. \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. [49], )Tj 0.141 Tw T* (\002\t\035 \r\t\001\036 \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\f\021\026\r\017\035 )Tj /T1_2 1 Tf 0 Tw (k)Tj /T1_1 1 Tf 0.141 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,48 \017)Tj /Span<>> BDC ( )Tj EMC /T1_2 1 Tf 0 Tw (k)Tj /T1_1 1 Tf 0.141 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,596, \f\024\024\021\r\036\021)Tj 0 Tw (-)Tj 0.102 Tw T* [(\f\021\r\036\027\027\024, )0.6(\004\021\024 )0.5(\f\004\017\021\026\036\021\f\016 )0.6(\031\n\036\030\036\027\027\t\n )0.5(\023\024\022\026\026\021\036\035\036\n )0.6(\r\024\f)]TJ 0 Tw (-)Tj 0.008 Tw T* [(\023\030\024\017\r\036\007\036\027\017\016, )0.6(\027\024 )0.5(\027\036 )0.5(\024\002\036\f\023\036\004\017\r\026\036\021 )0.6(\027\036\024\002\b\024\007\017\n\024\005 )0.5(\021\024\004)]TJ 0 Tw (-)Tj -0.029 Tw T* (\027\024\f\021\017 \r)Tj /Span<>> BDC ( )Tj EMC (\024\006\036\027\022\036 \220\021\024\020\024 \020\017\f\021\024\035\024\ \020\017\004\036\f\022\024\020\024 \023\030\017\027\026\022\026. \212\035\ \016 )Tj 0.2 Tw T* (\030\036\001\036\027\017\016 \220\021\024\005 \023\030\024\002\035\036\n\ \t \007\035\017\021\036\035\034\027\024 \023\030\017\n\036\027\016\r\001\ \026\016\f\016 )Tj 0.019 Tw T* (\f\017\f\021\036\n\026 \004\036\021\t\030\036\b\f\021\031\023\036\027\004\ \026\021\024\005 \024\006\036\027\022\017 \f\021\036\023\036\027\017 \007\ \017\235\235\036)Tj 0 Tw (-)Tj 0.328 Tw T* (\030\036\027\006\017\030\024\r\022\017 \(\r\t\f\024\022\024-, \031\n\036\ \030\036\027\027\024-, \027\017\022\024\007\017\235\235\036\030\036\027\ )Tj 0 Tw (-)Tj 0.412 Tw T* (\006\017\030\024\r\026\027\027\026\016 \026\007\036\027\024\022\026\030\006\ \017\027\024\n\t \017)Tj /Span<>> BDC ( )Tj EMC (\027\036\007\017\235\235\036\030\036\027\006\017\030\024)Tj 0 Tw (-)Tj 0.184 Tw T* (\r\026\027\027\t\005 \030\026\022\) \r)Tj /Span<>> BDC ( )Tj EMC (\023\024\f\035\036\007\027\036\005 \022\035\026\f\f\017\235\017\022\026\006\ \017\017 \024\023\031\b\024\035\036\005 )Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 0 Tw 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\206)10(\002\036\033 \035\030\032\003\033)30(\n)42(\032)-21(\230\033\241)]TJ 57.136 0 Td (REVIEW)Tj /T1_3 1 Tf 25 0 0 25 504.6771 56.0378 Tm (181)Tj ET endstream endobj 58 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 59 0 obj <>/ExtGState<>/Font<>/ProcSet[/PDF/Text]/Properties<>/Shading<>/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 60 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 61 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 62 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1113 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.009 Tw 10 0 0 10 70.8661 724.8299 Tm (\2301. \200)Tj /Span<>> BDC ( )Tj EMC [(\030\026\002\024\021\026\b It)17(o)]TJ /Span<>> BDC ( )Tj EMC (T. \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. \(2022\) [33] \017)Tj /Span<>> BDC ( )Tj EMC [(K)25(ouy)22(ama)]TJ /Span<>> BDC ( )Tj EMC (Y. )Tj 0.253 Tw 0 -1.218 TD (\017)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. \(2023\) [32] \023\024\022\026\026\027\024, \004\021\024\ \f\021\030\026\021\017\235\017\022\026\006\017\016 )Tj 0.515 Tw T* [(\023\026\006\017\036\027\021\024\r )0.6(\024\021\027\024\f\017\021\036\035\034\027\024 )0.5(\030\017\f\022\026 )0.6(\n\036\021\026\f\021\026\017\030\024\r\026\027\017\016 )]TJ 0.129 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\035\017\n\235\024\031\035\t \f)Tj /Span<>> BDC ( )Tj EMC (\020\035\031\002\017\027\024\005 \023\024\007\f\035\017\017\f\021\024\005\ \017\027\r\026\017\017 \002\024)Tj 0 Tw (-)Tj 0.031 Tw T* (\035\036\036 1 \n\n \r\027\036 \026\r\017\f\017\n\024\f\021\017 \024\021\ \007\030\031\020\017\b \020\017\f\021\024\035\024\020\017\004\036\f\022\ \017\b )Tj 0.036 Tw T* [(\023\026\030\026\n\036\021\030\024\r )0.5(\031\r\036\035\017\004\017\r\026\036\021 )0.6(\022\024\035\017\004\036\f\021\r\024 )0.6(\023\026\006\017\036\027\021\024\r )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC 20.757 0 Td (\023\024)Tj 0 Tw (-)Tj 0.384 Tw -20.757 -1.218 Td (\022\026\026\027\017\036\n \022)Tj /Span<>> BDC ( )Tj EMC [(\007\024\023\024\035\027\017\021\036\035\034\027\024\n\031 )0.5(\035\036\004\036\027\017\033. \203\026\023\030\024\021\017\r, )]TJ 0.142 Tw T* (\017\f\022\035\033\004\036\027\017\036 \024\023\031\b\024\035\036\005 \f\ )Tj /Span<>> BDC ( )Tj EMC (\020\035\031\002\024\022\024\005 \017\027\r\026\017\036\005 \023\024\007\ \f\035\017)Tj 0 Tw (-)Tj -0.057 Tw T* (\017\f\021\024\005 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\024\021\f\031\021\f\021\r\017\017 \007\030\031\020\017\b \020\017\f\021\ \024\035\024\020\017\004\036\f\022\017\b \235\026\022\021\024)Tj 0 Tw (-)Tj -0.004 Tw T* (\030\024\r \030\017\f\022\026 \017)Tj /Span<>> BDC ( )Tj EMC (\004\017\f\035\026 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[32], \004\026\f\021\024\021\026 )Tj 0.112 Tw 0 -1.218 TD (\030\036\006\017\007\017\r\024\r \017)Tj /Span<>> BDC ( )Tj EMC (\023\016\021\017\035\036\021\027\016\016 \r\t\032\017\r\026\036\n\024\f\021\ \034 \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r )Tj 0.133 Tw 0 -1.218 TD (\f)Tj /Span<>> BDC ( )Tj EMC (\020\035\031\002\024\022\024\005 \023\024\007\f\035\017\017\f\021\024\005\ \017\027\r\026\017\036\005 \002\036 \007\030\031\020\017\b \n\024\030\ )Tj 0 Tw (-)Tj 0.029 Tw T* (\235\024\035\024\020\017\004\036\f\022\017\b \235\026\022\021\024\030\024\ \r \030\017\f\022\026 \(\020\030\031\023\023\026 T1b\) \002\t\035\017 \f\ \024)Tj 0 Tw (-)Tj 0.129 Tw T* (\023\024\f\021\026\r\017\n\t \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\026\b \f)Tj /Span<>> BDC ( )Tj EMC (\220\027\007\024\f\022\024\023\017\004\036\f\022\017\n \031\007\026\035\036\ \027\017\036\n )Tj 0 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\030\036\036\022\006\017\036\005 \022\017\001\022\017.)Tj 0.056 Tw T* (\236\031\004\036\027\017\036 \023\030\024\020\027\024\f\021\017\004\036\ \f\022\024\020\024 \027\026\004\036\027\017\016 \020\035\031\002\017\027\ \t \017\027\r\026)Tj 0 Tw (-)Tj 0.108 Tw T* (\017\017 \f)Tj /Span<>> BDC ( )Tj EMC (\017\f\023\024\035\034\024\r\026\027\017\036\n \023\024\035\031\022\024\ \035\017\004\036\f\021\r\036\027\027\t\b \n\036\021\024\007\017\022 )Tj 0.238 Tw T* (\024\006\036\027\022\017 \021\026\022\032\036 \023\024\022\026\026\035\024\ \027\036\024\007\027\024\027\026\004\027\t\036 \030\036\031\035\034\021\ \026\021\t )Tj 0.104 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\002\035\036\n\t \r)Tj /Span<>> BDC ( )Tj EMC (\017\n\036\030\036\027\017\017. \025\030\024\n\036 \021\024\020\024, \023\ \030\026\022\021\017\004\036\f\022\024\036 )Tj 0.168 Tw T* [(\023\030\017\n\036\027\036\027\017\036 )0.6(\023\030\036\007\035\026\020\026\036\n\t\b )0.5(\023\024\035\031\022\024\035\017\004\036\f\021\r\036\027\027\t\b )0.7(\n\036)]TJ 0 Tw (-)Tj 0.062 Tw T* (\021\024\007\017\022 \024\006\036\027\022\017 \020\035\031\002\017\027\t\ \023\024\007\f\035\017\017\f\021\024\005 \017\027\r\026\017\017, \017\ )Tj /Span<>> BDC ( )Tj EMC (\022\024)Tj 0 Tw (-)Tj 0.03 Tw T* (\021\024\030\t\b \027\026\017\002\024\035\036\036 \023\030\017\n\036\027\ \017\n\t\n\017 \027\026)Tj /Span<>> BDC ( )Tj EMC (\023\030\026\022\021\017\022\036 \016\r\035\016\033\021\f\016 )Tj 0.125 Tw T* (\022\035\026\f\f\017\235\017\022\026\006\017\017 Kikuchi \017)Tj /Span<>> BDC ( )Tj EMC [(Ha)-17(ggi)-23.9(t)-30(t, \017\n\036\036\021 \f\031\013\036\f\021\r\036\027)]TJ 0 Tw (-)Tj 0.526 Tw T* [(\027\t\036 \024\020\030\026\027\017\004\036\027\017\016 )0.5(\023\030\017)]TJ /Span<>> BDC ( )Tj EMC (\023\026\021\024\n\024\030\235\024\035\024\020\017\004\036\f\022\024\n \017\ \f)Tj 0 Tw (-)Tj 0.243 Tw T* [(\f\035\036\007\024\r\026\027\017\017 )0.5(\031\007\026\035\036\027\027\t\b )0.5(\n\026\035\017\020\027\017\017\030\024\r\026\027\027\t\b )0.6(\026\007\036\027\024\n )]TJ 0.043 Tw T* 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[34], \017\031\004\026\016 \220\235\235\036\022\021\017\r\027\024\f\021\ \034 )Tj -0.02 Tw T* [(\023\030\017\n\036\027\036\027\017\016 \022\035\026\f\f\017\235\017\022\026\ \006\017\005 Ha)-16.9(ggi)-24(t)-30(t, Kikuchi \027\026)]TJ /Span<>> BDC ( )Tj EMC (\023\030\026\022)Tj 0 Tw (-)Tj 0.213 Tw T* (\021\017\022\036, \023\030\024\007\036\n\024\027\f\021\030\017\030\024\r\ \026\035, \004\021\024 \024\027\017 \017\n\036\033\021 \007\024\r\024\035\ \034\027\024 )Tj 0.148 Tw T* (\027\017\022\031\033 \r\024\f\023\030\024\017\r\024\007\017\n\024\f\021\ \034 \f\030\036\007\017 \023\026\021\024\035\024\020\024\r \(\022\024\220\ \235)Tj 0 Tw (-)Tj 0.101 Tw T* [(\235\017\006\017\036\027\021 )0.5(\025\024\220\027\026 )]TJ /T1_1 1 Tf 0 Tw (k)Tj /T1_0 1 Tf 0.101 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,36 \017)Tj /Span<>> BDC ( )Tj EMC /T1_1 1 Tf 0 Tw (k)Tj /T1_0 1 Tf 0.101 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,15, \f\024\024\021\r\036\021\f\021\r\036\027\027\024\). )Tj 0.205 Tw T* [(\215\030\017\n\036\004\026\021\036\035\034\027\t\n )0.6(\016\r\035\016\036\021\f\016 )0.5(\021\024\021 )0.6(\235\026\022\021, )0.5(\004\021\024 )0.5(\017\n\036\027\036\027\017\036 )]TJ 0.281 Tw T* (\r\020\035\016\007\024\r \024\021\027\024\f\017\021\036\035\034\027\024\ \023\030\024\020\027\024\f\021\017\004\036\f\022\024\020\024 \027\026\004\ \036\027\017\016 )Tj 0.335 Tw T* (\020\035\031\002\017\027\t \023\024\007\f\035\017\017\f\021\024\005 \017\ \027\r\026\017\017 \027\026\001\035\024 \f\r\024\036 \024\021\030\026)Tj 0 Tw (-)Tj 0.23 Tw T* [(\032\036\027\017\036 )0.6(\r)]TJ /Span<>> BDC ( )Tj EMC 4.02 0 Td [(\023\024\f\035\036\007\027\036\n )0.6(\023\036\030\036\f\n\024\021\030\036 )0.5(\030\031\022\024\r\024\007\f\021\r\026 )0.6(JCS)17(SR )]TJ 0.127 Tw -4.02 -1.218 Td (2019)Tj /Span<>> BDC ( )Tj EMC (\020. [12], \020\007\036 \023\024\007\004\036\030\022\017\r\026\036\021\f\ \016, \004\021\024 \027\036 \r\f\036 \f\035\031\004\026\017 )Tj 0.283 Tw T* (\026\007\036\027\024\022\026\030\006\017\027\024\n\t \f)Tj /Span<>> BDC ( )Tj EMC (\023\024\007\f\035\017\017\f\021\024\005 \017\027\r\026\017\036\005 \020\ \035\031\002\032\036 )Tj 0.368 Tw T* (1000)Tj /Span<>> BDC ( )Tj EMC 2.6 0 Td [(\n\022\n )0.5(\027\031\032\007\026\033\021\f\016 )0.6(\r)]TJ /Span<>> BDC ( )Tj EMC 8.414 0 Td [(\007\024\023\024\035\027\017\021\036\035\034\027\024\n )0.6(\b\017\030\031\030\020\017)]TJ 0 Tw (-)Tj 0.399 Tw -11.015 -1.218 Td (\004\036\f\022\024\n \035\036\004\036\027\017\017. \215\030\017)Tj /Span<>> BDC ( )Tj EMC (\024\021\f\031\021\f\021\r\017\017 \020\017\f\021\024\035\024\020\017\004\ \036\f\022\017\b )Tj 0.141 Tw T* (\235\026\022\021\024\030\024\r \030\017\f\022\026 \017)Tj /Span<>> BDC ( )Tj EMC (\030\026\007\017\022\026\035\034\027\024\n \031\007\026\035\036\027\017\017\ \r\024\n\024\032\027\026 )Tj 0.058 Tw T* [(\021\026\022\021\017\022\026 )0.5(\027\026\002\035\033\007\036\027\017\016 )0.5(\r\r\017\007\031 \027\017\022\024\020\024 )0.5(\030\017\f\022\026 \(2,6%\) \n\036)]TJ 0 Tw (-)Tj T* (\021\026\f\021\026\017\030\024\r\026\027\017\016 \024\023\031\b\024\035\ \017.)Tj /T1_1 1 Tf 23.244 64.543 Td (\245\022\033\022\020\037 \022)Tj /Span<>> BDC ( )Tj EMC (\f\027\034\235\037\b\003 \f\034\b\024\027\022\031\022\024\035\034\004 \022\ \020\036\037\031\022\022)Tj /T1_0 1 Tf 0.175 Tw T* (\224 \006\036\035\034\033 \023\024\017\f\022\026 \026\035\034\021\036\030\ \027\026\021\017\r\027\t\b \020\035\031\002\017\027\036 \023\024\007\f\035\ \017\017)Tj 0 Tw (-)Tj 0.251 Tw T* [(\f\021\024\005 \017\027\r\026\017\017 \n\024\030\235\024\n\036\021\030\017\ \004\036\f\022\017\b \023\026\030\026\n\036\021\030\024\r )0.5(\002\t\035\017 )]TJ 0.33 Tw T* (\023\030\036\007\035\024\032\036\027\t \007\030\031\020\017\036 \022\030\ \017\021\036\030\017\017 \024\006\036\027\022\017 \030\026\f\023\030\024\ \f\021\030\026)Tj 0 Tw (-)Tj 0.014 Tw T* (\027\036\027\027\024\f\021\017 \024\023\031\b\024\035\017, \021\026\022\017\ \036 \022\026\022 \001\017\030\017\027\026 \017)Tj /Span<>> BDC ( )Tj EMC (\023\035\024\013\026\007\034 \024\027\t )Tj 0.194 Tw T* (\024\023\031\b\024\035\036\r\024\005 \017\027\r\026\017\017 \r)Tj /Span<>> BDC ( )Tj EMC (\023\024\007\f\035\017\017\f\021\024\n \f\035\024\036, \022\024\021\024\ \030\t\036 )Tj 0.346 Tw 0 -1.218 TD [(\n\024\020\035\017 )0.5(\002\t )0.5(\017\f\023\024\035\034\024\r\026\021\034\f\016 )0.6(\007\035\016 )0.5(\024\023\030\036\007\036\035\036\027\017\016 )0.6(\030\017\f\022\026 )]TJ 0.516 Tw 0 -1.218 TD (\n\036\021\026\f\021\026\017\030\024\r\026\027\017\016. \210\023\031\002\ \035\017\022\024\r\026\027\027\t\036 \017\f\f\035\036\007\024\r\026\027\017\ \016 )Tj 0.05 Tw T* (\007\026\027\027\t\b \023\026\030\026\n\036\021\030\024\r \030\026\f\023\ \030\024\f\021\030\026\027\036\027\017\016 \024\023\031\b\024\035\017 \027\ \036 \021\026\022 )Tj -0.019 Tw T* (\n\027\024\020\024\004\017\f\035\036\027\027\t, \022\026\022 \017\f\f\035\ \036\007\024\r\026\027\017\016, \023\024\f\r\016\013\036\027\027\t\036 \020\ \035\031)Tj 0 Tw (-)Tj 0.049 Tw T* (\002\017\027\036 \023\024\007\f\035\017\017\f\021\024\005 \017\027\r\026\ \017\017, \026)Tj /Span<>> BDC ( )Tj EMC (\023\024\035\031\004\036\027\027\t\036 \030\036\031\035\034\021\026)Tj 0 Tw (-)Tj 0.015 Tw T* [(\021\t \024\022\026\026\035\017\f\034 \021\026\022\032\036 \027\036\024\ \007\027\024\027\026\004\027\t. Suzuk)-15.9(i)]TJ /Span<>> BDC ( )Tj EMC (T. \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. )Tj 0.335 Tw 0 -1.218 TD (\(2003\) [35] \024\007\027\017 \017)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\r\t\b \023\030\024\007\036\n\024\027\f\021\030\017\030\024\r\ \026\035\017 )Tj -0.025 Tw 0 -1.218 TD (\023\030\024\020\027\024\f\021\017\004\036\f\022\024\036 \027\026\004\036\ \027\017\036 \001\017\030\017\027\t \023\024\007\f\035\017\017\f\021\024\ \005 \017\027)Tj 0 Tw (-)Tj 0.092 Tw 0 -1.218 TD (\r\026\017\017, \024\023\030\036\007\036\035\017\r \023\024\030\024\020\ \024\r\024\036 \027\026\004\036\027\017\036 5 \n\n)Tj 0 Tw 5.83 0 0 5.83 487.2782 557.6678 Tm (2)Tj 0.092 Tw 10 0 0 10 490.1932 554.3378 Tm (, \023\030\036\r\t)Tj 0 Tw (-)Tj 0.093 Tw -18.689 -1.218 Td (\001\036\027\017\036 \022\024\021\024\030\024\020\024 \031\r\036\035\017\ \004\017\r\026\035\024 \030\017\f\022 \n\036\021\026\f\021\026\021\017\004\ \036\f\022\024\020\024 )Tj 0.192 Tw T* (\023\024\030\026\032\036\027\017\016 \035\017\n\235\024\031\035\024\r \(\ 0% \023\030\024\021\017\r 30%\). Ueno)Tj /Span<>> BDC ( )Tj EMC (H. )Tj 0.076 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. \(2004\) [29] \023\024\022\026\026\035\017 \007\024\f\ \021\024\r\036\030\027\024\036 \031\r\036\035\017\004\036)Tj 0 Tw (-)Tj -0.008 Tw T* (\027\017\036 \030\017\f\022\026 \n\036\021\026\f\021\026\017\030\024\r\026\ \027\017\016 \r)Tj /Span<>> BDC ( )Tj EMC (\035\017\n\235\024\031\035\t \(2,5% \023\030\024)Tj 0 Tw (-)Tj -0.036 Tw T* (\021\017\r 18,2%, )Tj /T1_1 1 Tf 0 Tw (\033)Tj /T1_0 1 Tf -0.036 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,003\) \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\031\r\036\035\017\004\036\027\017\017 \001\017\030\017\027\t \023\024\007\ \f\035\017)Tj 0 Tw (-)Tj 0.117 Tw T* (\017\f\021\024\005 \017\027\r\026\017\017 \f)Tj /Span<>> BDC ( )Tj EMC (\023\024\030\024\020\024\r\t\n \027\026\004\036\027\017\036\n \r)Tj /Span<>> BDC ( )Tj EMC (4000)Tj /Span<>> BDC ( )Tj EMC (\n\022\n )Tj 0.792 Tw T* (\(4)Tj /Span<>> BDC ( )Tj EMC 1.37 0 Td (\n\n\), \023\030\036\r\t\001\036\027\017\036 \022\024\021\024\030\024\020\ \024 \030\026\f\f\n\026\021\030\017\r\026\035\024\f\034 )Tj 0.585 Tw -1.37 -1.218 Td (\026\r\021\024\030\026\n\017 \022\026\022 \027\036\002\035\026\020\024\023\ \030\017\016\021\027\t\005 \023\030\024\020\027\024\f\021\017\004\036\f\022\ \017\005 )Tj 0.228 Tw T* (\023\030\017\027\026\022. \210\007\027\026\022\024, \022\026\022 \017)Tj /Span<>> BDC ( )Tj EMC (\007\035\016 \020\035\031\002\017\027\t \023\024\007\f\035\017\017\f\021\ \024\005 )Tj 0.406 Tw T* (\017\027\r\026\017\017, \023\024\035\031\004\036\027\027\t\036 \023\024\ \032\036 \030\036\031\035\034\021\026\021\t \017\031\004\036\027\017\016\ )Tj 0.032 Tw T* (\r\026\017\n\024\f\r\016\017 \001\017\030\017\027\t \017)Tj /Span<>> BDC ( )Tj EMC (\023\035\024\013\026\007\017 \023\024\007\f\035\017\017\f\021\024\005 \017\ \027\r\026)Tj 0 Tw (-)Tj 0.111 Tw T* (\017\017 \f)Tj /Span<>> BDC ( )Tj EMC (\004\026\f\021\024\021\024\005 \r\t\016\r\035\036\027\017\016 \n\036\021\ \026\f\021\026\024\r \r)Tj /Span<>> BDC ( )Tj EMC (\035\017\n\235\024\031\035\026\b )Tj 0.005 Tw T* (\023\030\017)Tj /Span<>> BDC ( )Tj EMC (\025\217\217 \2301 \024\022\026\026\035\017\f\034 \027\036 \f\021\024\035\ \034 \024\007\027\024\027\026\004\027\t. \200)Tj /Span<>> BDC ( )Tj EMC (\024\002\024\030\036 )Tj -0.024 Tw T* [(\017\f\f\035\036\007\024\r\026\027\017\005, )0.5(\023\030\024\r\036\007\036\027\027\024\n )0.5(Cr)-33(a)-17(cco)]TJ /Span<>> BDC ( )Tj EMC [(N. )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC [(\f\024\026\r\021. )0.5(\(2021\) )]TJ -0.035 Tw T* ([36], \021\024\035\034\022\024 \r)Tj /Span<>> BDC ( )Tj EMC (\023\024\035\024\r\017\027\036 \017\f\f\035\036\007\024\r\026\027\017\005\ \017)Tj /Span<>> BDC ( )Tj EMC (\r\024\f\034\n\017, \017\031)Tj 0 Tw (-)Tj -0.019 Tw T* (\004\026\r\001\017\b \007\026\027\027\t\036 \023\026\030\026\n\036\021\030\ \t \017)Tj /Span<>> BDC ( )Tj EMC (\024\023\031\002\035\017\022\024\r\026\027\027\t\b \r)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\017)Tj 0 Tw (-)Tj 0.028 Tw T* (\024\007 \f)Tj /Span<>> BDC ( )Tj EMC (2003 \023\024)Tj /Span<>> BDC ( )Tj EMC [(2019 \020\020. \(Suzuk)-15.9(i)]TJ /Span<>> BDC ( )Tj EMC (T., 2003; Ueno)Tj /Span<>> BDC ( )Tj EMC (H., 2004; )Tj 0.138 Tw T* [(T)45(oh)]TJ /Span<>> BDC ( )Tj EMC [(EW., 2015; Y)-29(im)]TJ /Span<>> BDC ( )Tj EMC (K., 2017\), \023\024\035\031\004\036\027\026 \007\024\f\021\024\r\036\030\ \027\026\016 )Tj 0.047 Tw T* (\r\026\017\n\024\f\r\016\034 \001\017\030\017\027\t \023\024\007\f\035\ \017\017\f\021\024\005 \017\027\r\026\017\017 \f)Tj /Span<>> BDC ( )Tj EMC (\004\026\f\021\024)Tj 0 Tw (-)Tj -0.044 Tw T* (\021\024\005 \n\036\021\026\f\021\026\017\030\024\r\026\027\017\016 \r)Tj /Span<>> BDC ( )Tj EMC (\035\017\n\235\024\031\035\t. \200)Tj /Span<>> BDC ( )Tj EMC (\017\f\f\035\036\007\024\r\026\027\017\016\b )Tj -0.066 Tw T* [(Suzuk)-15.9(i)]TJ /Span<>> BDC ( )Tj EMC [(T.\(2003\) [35], Y)-29(im)]TJ /Span<>> BDC ( )Tj EMC [(K. \(2017\) [37], Bar)-23.9(el)]TJ /Span<>> BDC ( )Tj EMC (F. \(2019\) )Tj 0.072 Tw T* ([38] \007\026\027\027\t\005 \023\026\030\026\n\036\021\030 \016\r\035\016\ \035\f\016 \002\024\035\036\036 \021\024\004\027\t\n \023\030\036\007\017\ )Tj 0 Tw (-)Tj 0.008 Tw T* (\022\021\024\030\024\n \n\036\021\026\f\021\026\017\030\024\r\026\027\017\ \016, \004\036\n \020\035\031\002\017\027\026 \023\024\007\f\035\017\017\ \f\021\024\005 )Tj 0.138 Tw T* [(\017\027\r\026\017\017. )0.5(\200)]TJ /Span<>> BDC ( )Tj EMC [(\002\030\017\021\026\027\f\022\024\n )0.5(\017\f\f\035\036\007\024\r\026\027\017\017 )0.5(T)45(oh)]TJ /Span<>> BDC ( )Tj EMC [(E. )0.5(\(2015\) )]TJ 0.071 Tw T* ([39] \017\031\004\036\027\017\036 \001\017\030\017\027\t \023\024\007\f\ \035\017\017\f\021\024\005 \017\027\r\026\017\017 \r)Tj /Span<>> BDC ( )Tj EMC (\026\007\036)Tj 0 Tw (-)Tj -0.037 Tw T* (\027\024\022\026\030\006\017\027\024\n\026\b \021\024\035\f\021\024\005 \ \022\017\001\022\017 \030\2301 \023\024\022\026\026\035\024 \007\024\f\021\ \024\r\036\030)Tj 0 Tw (-)Tj 0.21 Tw T* (\027\031\033 \026\f\f\024\006\017\026\006\017\033 \007\026\027\027\024\020\ \024 \023\026\030\026\n\036\021\030\026 \f)Tj /Span<>> BDC ( )Tj EMC (\n\036\021\026\f\021\026\026\n\017 )Tj 0.523 Tw T* [(\026\007\036\027\024\022\026\030\006\017\027\024\n\t )0.6(\r)]TJ /Span<>> BDC ( )Tj EMC 9.071 0 Td [(\035\017\n\235\024\031\035\026\b. )0.5(\210\023\031\002\035\017\022\024\r\026\027\027\t\036 )]TJ 0.105 Tw -9.071 -1.218 Td (\030\036\031\035\034\021\026\021\t \007\036\n\024\027\f\021\030\017\030\ \031\033\021 \027\026\004\017\021\036\035\034\027\t\036 \022\024\035\036\ \002\026\027\017\016 )Tj 0.065 Tw T* [(\023\024\035\031\004\036\027\027\t\b )0.5(\023\024\030\024\020\024\r\t\b )0.5(\027\026\004\036\027\017\005)]TJ /Span<>> BDC ( )Tj EMC 14.124 0 Td [(\227 \024\021 )0.5(2 \007\024)]TJ /Span<>> BDC ( )Tj EMC 4.565 0 Td (11,5 \n\n. )Tj 0.579 Tw -18.69 -1.218 Td (\203\026\017\002\024\035\034\001\036\036 \007\017\235\235\036\030\036\027\ \006\017\026\035\034\027\024\036 \027\026\004\036\027\017\036 \017\n\036\ \035\017 )Tj 0.136 Tw T* (\023\024\030\024\020\024\r\t\036 \r\036\035\017\004\017\027\t, \030\026\r\ \027\t\036 2\2263)Tj /Span<>> BDC ( )Tj EMC (\n\n, \023\024\r\024\035\016\033\013\017\036 )Tj 0.069 Tw T* (\024\023\030\036\007\036\035\016\021\034 \024\023\031\b\024\035\017 \f)Tj /Span<>> BDC ( )Tj EMC (\027\017\022\017\n \017)Tj /Span<>> BDC ( )Tj EMC (\r\t\f\024\022\017\n \030\017\f\022\024\n \n\036)Tj 0 Tw (-)Tj 0.013 Tw T* [(\021\026\f\021\026\017\030\024\r\026\027\017\016 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 7.473 0 Td [(\035\017\n\235\024\031\035\t, )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC [(\021\024 )0.5(\r\030\036\n\016 )0.5(\022\026\022 \023\030\017)]TJ /Span<>> BDC ( )Tj EMC 13.097 0 Td (\001\017)Tj 0 Tw (-)Tj 0.017 Tw -20.57 -1.218 Td (\030\017\027\036 \023\024\007\f\035\017\017\f\021\024\005 \017\027\r\026\ \017\017)Tj /Span<>> BDC ( )Tj EMC (\245)Tj /Span<>> BDC ( )Tj EMC (2 \n\n \027\017 \r)Tj /Span<>> BDC ( )Tj EMC (\024\007\027\024\n \017)Tj /Span<>> BDC ( )Tj EMC (\017\f)Tj 0 Tw (-)Tj 0.086 Tw T* (\f\035\036\007\024\r\026\027\017\005 \n\036\021\026\f\021\026\t \r)Tj /Span<>> BDC ( )Tj EMC (\035\017\n\235\024\031\035\026\b \027\036 \024\021\n\036\004\026\035\017\ \f\034. )Tj 0.2 Tw T* (\215\024)Tj /Span<>> BDC ( )Tj EMC [(\007\026\027\027\t\n Daven)11(por)-22(t)]TJ /Span<>> BDC ( )Tj EMC (\202. [34], \027\026)Tj /Span<>> BDC ( )Tj EMC (\023\030\026\022\021\017\022\036 \001\017\030\017\027\026 )Tj 0.18 Tw T* (\023\024\007\f\035\017\017\f\021\024\005 \017\027\r\026\017\017, \022\026\ \022 \n\024\030\235\024\035\024\020\017\004\036\f\022\017\005 \023\026\030\ \026)Tj 0 Tw (-)Tj 0.281 Tw T* (\n\036\021\030, \023\024\022\026\026\035\026 \002\024\035\036\036 \r\t\f\ \024\022\031\033 \r\024\f\023\030\024\017\r\024\007\017\n\024\f\021\034\ )Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0 Tw 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\206)10(\002\036\033 \035\030\032\003\033)30(\n)42(\032)-21(\230\033\241)]TJ 57.136 0 Td (REVIEW)Tj -57.136 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 2)69(4, \023\0224, 202)23(5)]TJ 43.013 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 2)69(4, \023\0224, 202)23(5)]TJ /T1_3 1 Tf 25 0 0 25 20.7902 56.0378 Tm (180)Tj ET endstream endobj 1112 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\034\201\025\235\t\016\024\220 \021\022\222\016\201\b\222\016\017)-9.9(\026\021\r\220 \222\201\021\024\016\215\016\215\021\004 \024\025\201\223\ \025\t\025\202\021\f\016\b\017\021 )]TJ 0 -1 TD [(\223\001\017)-10(\026)11(\025\201\025\r \201\021\b\017\001 \024\016\026)11(\001\b)-10(\026)11(\001\213\021\201\025\r\001\215\021\004 \r\022\t\021\024\223\001\026\021\f\ \016\b\017\021\016 \200)31(\213\t\220 )]TJ T* [(\222\201\021\022\017)10(\025\t\025\201\016\017)-10(\026)11(\001\t\214\215\025\024 \201\001\017\016 \0321 \(\025\235\213\025\201 \t\021\ \026)11(\016\201\001\026)-20(\200\201\220\))]TJ 37.237 2 Td [(Pr)20(oblems and pr)20(ospects of\022using morph)11(ological risk factor)20.1(s )]TJ 0.243 -1 Td [(for\022lymph node metastasis in T1 color)31(ectal cancer \(r)31(e)11(vie)11(w\))]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0.044 Tw 10 0 0 10 42.5197 724.8299 Tm (\n\036\021\026\f\021\026\017\030\024\r\026\027\017\016 \024\021 \020\035\ \031\002\017\027\t \023\024\007\f\035\017\017\f\021\024\005 \017\027\r\026\ \017\017 )Tj 0.121 Tw 0 -1.218 TD ([6,28]. \203\026)Tj /Span<>> BDC ( )Tj EMC (\024\f\027\024\r\026\027\017\017 \023\024\035\031\004\036\027\027\t\b \016\ \023\024\027\f\022\017\n\017 \017\f\f\035\036)Tj 0 Tw (-)Tj 0.131 Tw T* (\007\024\r\026\021\036\035\016\n\017 \007\026\027\027\t\b \002\t\035\026\ \f\235\024\030\n\017\030\024\r\026\027\026 \022\024\027\006\036\023\006\ \017\016, )Tj 0.128 Tw T* (\004\021\024 \020\035\031\002\017\027\026 \017\027\r\026\017\017 \r)Tj /Span<>> BDC ( )Tj EMC (\023\024\007\f\035\017\017\f\021\t\005 \f\035\024\005 \016\r\035\016\036\ \021\f\016 )Tj 0.341 Tw T* (\r\026\032\027\t\n \017\027\007\017\022\026\021\024\030\024\n \n\036\021\ \026\f\021\026\017\030\024\r\026\027\017\016 \r)Tj /Span<>> BDC ( )Tj EMC (\035\017\n\235\024)Tj 0 Tw (-)Tj 0.279 Tw T* [(\031\035\t. )0.5(\212\035\016 \024\006\036\027\022\017 )0.5(\007\026\027\027\024\020\024 )0.5(\023\026\030\026\n\036\021\030\026 \023\030\017)]TJ /Span<>> BDC ( )Tj EMC 19.019 0 Td (\n\024\030\235\024)Tj 0 Tw (-)Tj 0.22 Tw -19.019 -1.218 Td (\035\024\020\017\004\036\f\022\024\n \017\f\f\035\036\007\024\r\026\027\017\ \017 \030\026\027\036\036 \002\t\035\017 \023\030\036\007\035\024\032\036\ \027\t )Tj 0.101 Tw T* (\n\036\021\024\007\017\022\017 \023\024\035\031\022\024\035\017\004\036\f\ \021\r\036\027\027\024\005 \024\006\036\027\022\017 \020\035\031\002\017\ \027\t \023\024\007)Tj 0 Tw (-)Tj 0.114 Tw T* (\f\035\017\017\f\021\024\005 \017\027\r\026\017\017, \027\026\017\002\024\ \035\036\036 \017\r\036\f\021\027\t\036 \017)Tj /Span<>> BDC ( )Tj EMC (\022\024\021\024\030\t\b )Tj -0.005 Tw T* [(\022\035\026\f\f\017\235\017\022\026\006\017\017 Ha)-17(ggi)-24(t)-30(t \(1985\) [29], K)25(ud)-16(o \(1993\) [30] )]TJ 0.088 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\n\024\007\017\235\017\022\026\006\017\017 Kikuchi \(1995\) [31] \017)Tj /Span<>> BDC ( )Tj EMC (\n\036\021\024\007 \022\024\035\017\004\036)Tj 0 Tw (-)Tj 0.314 Tw T* (\f\021\r\036\027\027\024\005 \024\006\036\027\022\017 \023\024\f\030\036\ \007\f\021\r\024\n \017\n\036\030\036\027\017\016 \020\035\031\002\017\027\ \t )Tj -0.04 Tw 0 -1.218 TD (\017\027\r\026\017\017 \r)Tj /Span<>> BDC ( )Tj EMC [(\026\002\f\024\035\033\021\027\t\b \006\017\235\030\026\b \(Ki)-23.9(t)15(ajima\) [28], \023\030\017\n\036)]TJ 0 Tw (-)Tj 0.041 Tw 0 -1.218 TD (\027\016\036\n\t\036 \027\026)Tj /Span<>> BDC ( )Tj EMC (\023\030\026\022\021\017\022\036 \r)Tj /Span<>> BDC ( )Tj EMC (\027\026\f\021\024\016\013\036\036 \r\030\036\n\016. \025\030\017\021\036\ \030\017\016\n\017 )Tj -0.056 Tw 0 -1.218 TD (\020\035\031\002\024\022\024\005 \017\027\r\026\017\017, \f\024\020\035\ \026\f\027\024 \007\026\027\027\t\n \022\035\026\f\f\017\235\017\022\026\ \006\017\016\n, )Tj -0.008 Tw T* (\f\004\017\021\026\033\021\f\016 \020\035\031\002\017\027\026 \017\027\r\ \026\017\017)Tj /Span<>> BDC ( )Tj EMC (\234)Tj /Span<>> BDC ( )Tj EMC (1 \n\n \023\024)Tj /Span<>> BDC ( )Tj EMC (\022\035\026\f\f\017\235\017\022\026\006\017\017 )Tj 0.072 Tw T* [(Ki)-24(t)15(ajima, s)26(m2-3 \023\024)]TJ /Span<>> BDC ( )Tj EMC (\022\035\026\f\f\017\235\017\022\026\006\017\017 Kikuchi \017)Tj /Span<>> BDC ( )Tj EMC (\031\030\024\r\036\027\034 )Tj 0 Tw T* (\017\027\r\026\017\017 4 \(level 4\) \023\024)Tj /Span<>> BDC ( )Tj EMC [(\022\035\026\f\f\017\235\017\022\026\006\017\017 Ha)-16.7(ggi)-24(t)-30(t.)]TJ 0.242 Tw T* (\210\007\027\026\022\024 \r)Tj /Span<>> BDC ( )Tj EMC (\023\024\f\035\036\007\027\017\036 \007\036\f\016\021\017\035\036\021\017\ \016 \024\023\031\002\035\017\022\024\r\026\027 \030\016\007 )Tj 0.432 Tw T* (\024\030\017\020\017\027\026\035\034\027\t\b \017\f\f\035\036\007\024\r\026\ \027\017\005 \017)Tj /Span<>> BDC ( )Tj EMC (\n\036\021\026\026\027\026\035\017\024\r, \023\024)Tj 0 Tw (-)Tj 0.318 Tw T* (\f\r\016\013\036\027\027\t\b \023\030\036\007\017\022\021\024\030\026\n \ \n\036\021\026\f\021\026\017\030\024\r\026\027\017\016 \r)Tj /Span<>> BDC ( )Tj EMC (\035\017\n)Tj 0 Tw (-)Tj 0.113 Tw T* (\235\026\021\017\004\036\f\022\017\036 \031\035\t \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\2301 \025\217\217, \r)Tj /Span<>> BDC ( )Tj EMC (\022\024\021\024\030\t\b \023\030\017\r\024\007\016\021\f\016 )Tj 0.332 Tw T* [(\007\024\r\024\035\034\027\024 )0.5(\023\030\024\021\017\r\024\030\036\004\017\r\t\036 )0.6(\030\036\031\035\034\021\026\021\t )0.6(\023\030\017\n\036\027\036\027\017\016 )]TJ 0.197 Tw T* (\020\035\031\002\017\027\t \023\024\007\f\035\017\017\f\021\024\005 \017\ \027\r\026\017\017, \022\026\022 \235\026\022\021\024\030\026 \030\017\f\ \022\026 )Tj 0.486 Tw T* (\n\036\021\026\f\021\026\017\030\024\r\026\027\017\016 \017, \r)Tj /Span<>> BDC ( )Tj EMC (\004\026\f\021\027\024\f\021\017, \017\f\023\024\035\034\024\r\026\027\017\ \036 )Tj 0.158 Tw T* (\023\024\030\024\020\024\r\024\020\024 \027\026\004\036\027\017\016 100\ 0 \n\022\n \(1 \n\n\). \025\030\024\n\036 \021\024\020\024, )Tj 0.129 Tw T* (\024\021\n\036\004\026\036\021\f\016, \004\021\024 \017\f\023\024\035\034\ \024\r\026\027\017\036 \023\030\036\007\035\024\032\036\027\027\024\020\ \024 \022\030\017)Tj 0 Tw (-)Tj 0.288 Tw T* (\021\036\030\017\016 \027\036\017\002\036\032\027\024 \023\030\017\r\024\ \007\017\021 \022)Tj /Span<>> BDC ( )Tj EMC (\031\r\036\035\017\004\036\027\017\033 \f\035\031\004\026\036\r )Tj 0.345 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\023\024\022\026\026\027\017\016\n\017 \007\035\016 \023\024\f\035\036\007\ \031\033\013\036\020\024 \b\017\030\031\030\020\017\004\036\f\022\024\020\ \024 )Tj 0.141 Tw T* [(\035\036\004\036\027\017\016 )0.6(\(sal)30(v)-15(a)-17(ge )0.5(sur)-32(ger)-23.9(y\) )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 12.124 0 Td [(\017\002\t\021\024\004\027\024\n\031 )0.6(\030\026\007\017\022\026\035\034)]TJ 0 Tw (-)Tj 0.772 Tw -12.124 -1.218 Td [(\027\024\n\031 \b\017\030\031\030\020\017\004\036\f\022\024\n\031 \035\036\ \004\036\027\017\033 \(over-tr)-23.9(ea)15(tment\) )]TJ 0 Tw T* ([7,18,23,25\22627].)Tj -0.045 Tw T* (\200 \f\017\f\021\036\n\026\021\017\004\036\f\022\024\n \024\002\024\030\ \036 Bosch)Tj /Span<>> BDC ( )Tj EMC (S. \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. [7], \r\022\035\033)Tj 0 Tw (-)Tj 0.051 Tw T* (\004\026\033\013\036\n 17 \017\f\f\035\036\007\024\r\026\027\017\005 \017\ )Tj /Span<>> BDC ( )Tj EMC (3621 \023\026\006\017\036\027\021\026, \023\030\024\r\036\007\036)Tj 0 Tw (-)Tj -0.025 Tw T* [(\027\024 )0.5(\f\030\026\r\027\036\027\017\036 )0.6(\030\026\035\017\004\027\t\b )0.5(\n\036\021\024\007\017\022 )0.5(\017\n\036\030\036\027\017\016 )0.5(\020\035\031\002\017\027\t )]TJ 0.447 Tw T* (\017\027\r\026\017\017 \(\022\024\035\017\004\036\f\021\r\036\027\027\t\ \b \017)Tj /Span<>> BDC ( )Tj EMC (\023\024\035\031\022\024\035\017\004\036\f\021\r\036\027\027\t\b\) )Tj 0.229 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC [(\023\030\024\020\027\024\f\021\017\004\036\f\022\024\036 \027\026\004\036\ \027\017\036 )0.5(\023\024\035\031\004\036\027\027\t\b \030\036\031\035\034\021\026)]TJ 0 Tw (-)Tj -0.009 Tw T* (\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC [(\024\006\036\027\022\024\005 )0.5(\017\b \004\031\r\f\021\r\017\021\036\035\034\027\024\f\021\017 \017)]TJ /Span<>> BDC ( )Tj EMC (\f\023\036\006\017\235\017\004\027\024\f\021\017. )Tj -0.056 Tw T* (\202\027\026\035\017 \007\026\027\027\t\b \023\024\022\026\026\035, \004\ \021\024 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\020\035\031\002\017\027\036 \017\027\r\026\017\017 1)Tj /Span<>> BDC ( )Tj EMC (\n\n )Tj 0.025 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\036\036 \023\024\r\t\001\026\035\f\016 \030\017\f\022 \n\036\ \021\026\f\021\026\017\030\024\r\026\027\017\016 \r)Tj /Span<>> BDC ( )Tj EMC (\035\017\n\235\024)Tj 0 Tw (-)Tj 0.042 Tw T* (\031\035\t \(RR5.2 [95% CI 1,8\22615,4]\), \017)Tj /Span<>> BDC ( )Tj EMC (\220\021\024 \023\024\030\024\020\024\r\024\036 \027\026)Tj 0 Tw (-)Tj -0.027 Tw T* (\004\036\027\017\036 \017\f\023\024\035\034\024\r\026\035\024\f\034 \007\ \035\016 \024\021\002\024\030\026 \023\026\006\017\036\027\021\024\r \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\031 )Tj -0.018 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\r\t\f\024\022\017\n \030\017\f\022\024\n \n\036\021\026\f\021\026\017\030\ \024\r\026\027\017\016. \210\007\027\026\022\024 \024\021\n\036\004\026)Tj 0 Tw (-)Tj 0.118 Tw T* (\035\024\f\034, \004\021\024 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\007\024\f\021\026\021\024\004\027\024 \r\t\f\024\022\024\005 \004\031\r\ \f\021\r\017\021\036\035\034\027\024\f\021\017 )Tj 0.133 Tw T* (\(96,7%\), \027\024 \027\017\022\024\005 \f\023\036\006\017\235\017\004\ \027\024\f\021\017 \(24,1%\) \007\026\027\027\024\020\024 )Tj 0.096 Tw T* (\023\030\017\027\026\022\026 \036\020\024 \017\f\023\024\035\034\024\r\ \026\027\017\036 \023\030\017\r\024\007\017\035\024 \022)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\034\001\024\n\031 )Tj 0.151 Tw T* (\022\024\035\017\004\036\f\021\r\031 \f\035\031\004\026\036\r, \r)Tj /Span<>> BDC ( )Tj EMC (\022\024\021\024\030\t\b \n\036\021\026\f\021\026\t \r)Tj /Span<>> BDC ( )Tj EMC (\031\007\026\035\036\027)Tj 0 Tw (-)Tj 0.075 Tw T* (\027\t\b \035\017\n\235\024\031\035\026\b \027\036 \024\023\030\036\007\ \036\035\016\035\017\f\034 \023\024\f\035\036 \023\030\024\r\036\007\036\ \027\017\016 )Tj 0.158 Tw T* (\007\024\023\024\035\027\017\021\036\035\034\027\024\020\024 \b\017\030\031\ \030\020\017\004\036\f\022\024\020\024 \035\036\004\036\027\017\016 \f)Tj /Span<>> BDC ( )Tj EMC (\035\017\n\235\024)Tj 0 Tw (-)Tj -0.065 Tw T* (\007\017\f\f\036\022\006\017\036\005. \200)Tj /Span<>> BDC ( )Tj EMC (\f\r\016\017 \f)Tj /Span<>> BDC ( )Tj EMC (\004\036\n \002\t\035 \f\007\036\035\026\027 \r\t\r\024\007 \024)Tj /Span<>> BDC ( )Tj EMC (\021\024\n, \004\021\024 )Tj -0.02 Tw T* (\023\024\030\024\020\024\r\024\036 \027\026\004\036\027\017\036 \r)Tj /Span<>> BDC ( )Tj EMC (1)Tj /Span<>> BDC ( )Tj EMC [(\n\n \027\036 \016\r\035\016\036\021\f\016 )0.5(\024\023\021\017\n\026\035\034\027\t\n, )]TJ 0.324 Tw T* (\026)Tj /Span<>> BDC ( )Tj EMC (\036\020\024 \023\024\017\021\017\r\027\024\036 \023\030\036\007\017\022\ \021\017\r\027\024\036 \027\026\004\036\027\017\036, \030\026\r\027\024\ \036 )Tj 0.114 Tw T* (12,3%, \027\036\r\036\035\017\022\024, \r)Tj /Span<>> BDC ( )Tj EMC (\021\024 \r\030\036\n\016 \022\026\022 \024\021\f\031\021\f\021\r\017\036\ \007\026\027\027\024\020\024 )Tj 0.19 Tw T* (\023\030\017\027\026\022\026 \n\024\032\036\021 \f\r\017\007\036\021\036\ \035\034\f\021\r\024\r\026\021\034 \024)Tj /Span<>> BDC ( )Tj EMC (\027\017\022\024\n \030\017\f\022\036 )Tj 0.429 Tw 23.244 64.543 Td (\n\036\021\026\f\021\026\017\030\024\r\026\027\017\016 \(\027\036\020\026\ \021\017\r\027\024\036 \023\030\036\007\017\022\021\017\r\027\024\036 \027\ \026)Tj 0 Tw (-)Tj 0.196 Tw T* (\004\036\027\017\036 98,5%\). \210\021\027\024\f\017\021\036\035\034\027\ \024 \023\030\024\020\027\024\f\021\017\004\036\f\022\024\020\024 \027\026\ )Tj 0 Tw (-)Tj 0.399 Tw T* [(\004\036\027\017\016 )0.5(\023\024\035\031\022\024\035\017\004\036\f\021\r\036\027\027\024\020\024\ )0.5(\024\023\030\036\007\036\035\036\027\017\016 )0.6(\020\035\031\002\017\027\t )]TJ -0.02 Tw T* [(\023\024\007\f\035\017\017\f\021\024\005 \017\027\r\026\017\017 s)26(m 2\2263)]TJ /Span<>> BDC ( )Tj EMC [(\023\030\024\021\017\r s)26(m1 \002\t\035\017 \023\024\035\031)]TJ 0 Tw (-)Tj 0.018 Tw T* (\004\036\027\t \f\024\023\024\f\021\026\r\017\n\t\036 \023\024\022\026\026\ \021\036\035\017: \004\031\r\f\021\r\017\021\036\035\034\027\024\f\021\034\ )Tj /Span<>> BDC ( )Tj EMC (\227 )Tj 0.178 Tw T* (92,7% \f\023\036\006\017\235\017\004\027\024\f\021\034)Tj /Span<>> BDC ( )Tj EMC (\227 30,4%, \023\024\017\021\017\r\027\024\036 \023\030\036\007\017)Tj 0 Tw (-)Tj 0.256 Tw 0 -1.218 TD (\022\021\017\r\027\024\036 \027\026\004\036\027\017\036)Tj /Span<>> BDC ( )Tj EMC (\227 16,8%, \027\036\020\026\021\017\r\027\024\036)Tj /Span<>> BDC ( )Tj EMC (\227 96,6%. )Tj 0.034 Tw 0 -1.218 TD [(K)25(ouy)22(ama)]TJ /Span<>> BDC ( )Tj EMC (Y. \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. \(2016\) [32] \021\026\022\032\036 \f\030\026\r\027\017\ \035\017 \030\026)Tj 0 Tw (-)Tj 0.092 Tw T* (\027\t\036 \n\036\021\024\007\017\022\017 \017\n\036\030\036\027\017\016\ \020\035\031\002\017\027\t \023\024\007\f\035\017\017\f\021\024\005 \017\ \027)Tj 0 Tw (-)Tj -0.046 Tw T* (\r\026\017\017, \023\024\022\026\026\r, \004\021\024 \017\f\023\024\035\ \034\024\r\026\027\017\036 \023\030\036\007\035\024\032\036\027\027\t\b\ \n\036)Tj 0 Tw (-)Tj 0.034 Tw T* [(\021\024\007\017\022 )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC [(\023\024\030\024\020\024\r\t\n )0.5(\027\026\004\036\027\017\036\n )0.5(1)]TJ /Span<>> BDC ( )Tj EMC [(\n\n )0.5(\(\2531000 \242m )0.5(r)-22(ule\273\) )]TJ 0.544 Tw T* (\017\n\036\036\021 \024\023\030\036\007\036\035\036\027\027\t\036 \f\035\ \024\032\027\024\f\021\017 \r)Tj /Span<>> BDC ( )Tj EMC (\023\030\026\022\021\017\004\036\f\022\024\n )Tj 0.27 Tw 0 -1.218 TD (\023\030\017\n\036\027\036\027\017\017, \024\002\031\f\035\024\r\035\036\ \027\027\t\036 \026\r\017\f\017\n\024\f\021\034\033 \030\036\031\035\034\ )Tj 0 Tw (-)Tj 0.13 Tw 0 -1.218 TD (\021\026\021\026 \024\021 \n\036\021\024\007\026 \017\n\036\030\036\027\ \017\016 \(\023\030\036\032\007\036 \r\f\036\020\024 \031\030\024\r\027\016\ , \024\021 )Tj 0 -1.218 TD (\022\024\021\024\030\024\020\024 \023\030\024\r\024\007\017\035\024\f\034\ \017\n\036\030\036\027\017\036\) \017, \022\026\022 \f\035\036\007\f\021\ \r\017\036, )Tj 0.406 Tw T* (\027\026\004\017\021\036\035\034\027\t\036 \030\026\f\b\024\032\007\036\ \027\017\016 \r)Tj /Span<>> BDC ( )Tj EMC (\024\006\036\027\022\036 \030\036\031\035\034\021\026\021\024\r )Tj 0.372 Tw T* (\017\n\036\030\036\027\017\016 \024\021\027\024\f\017\021\036\035\034\027\ \024 \030\017\f\022\026 \n\036\021\026\f\021\026\017\030\024\r\026\027\017\ \016. )Tj 0.062 Tw T* [(\210\f\027\024\r\t\r\026\016\f\034 )0.5(\027\026)]TJ /Span<>> BDC ( )Tj EMC 6.943 0 Td [(\023\024\035\031\004\036\027\027\t\b )0.6(\007\026\027\027\t\b, )0.5(\026\r\021\024\030\t )0.6(\023\030\017\001\035\017 )]TJ -0.04 Tw -6.943 -1.218 Td (\022)Tj /Span<>> BDC ( )Tj EMC (\r\t\r\024\007\031 \024)Tj /Span<>> BDC ( )Tj EMC (\f\035\026\002\024\n \f\026\n\024\f\021\024\016\021\036\035\034\027\024\n\ \023\030\024\020\027\024\f\021\017\004\036\f\022\024\n )Tj -0.02 Tw T* [(\027\026\004\036\027\017\017 )0.6(\020\035\031\002\017\027\t )0.5(\023\024\007\f\035\017\017\f\021\024\005 )0.6(\017\027\r\026\017\017 )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC 17.96 0 Td (\017\f\023\024\035\034\024)Tj 0 Tw (-)Tj 0.161 Tw -17.96 -1.218 Td (\r\026\027\017\036\n \023\024\030\024\020\024\r\024\020\024 \027\026\004\ \036\027\017\016 1 \n\n, \023\024\007\004\036\030\022)Tj /Span<>> BDC ( )Tj EMC 18.752 0 Td (\027\031\r, \004\021\024 )Tj 0.672 Tw -18.752 -1.218 Td (\020\017\f\021\024\035\024\020\017\004\036\f\022\017\036 \b\026\030\026\022\ \021\036\030\017\f\021\017\022\017 \024\023\031\b\024\035\017 \017\n\036\ \033\021 )Tj -0.033 Tw T* (\002\024\035\034\001\036\036 \023\030\024\020\027\024\f\021\017\004\036\f\ \022\024\036 \027\026\004\036\027\017\036. \200)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\036\036 \023\024\007\027\036\n )Tj 0.032 Tw T* [(\017\f\f\035\036\007\024\r\026\027\017\017 )0.6(Aiza)10(w)-12(a)]TJ /Span<>> BDC ( )Tj EMC 9.152 0 Td [(D. )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 1.899 0 Td [(\f\024\026\r\021. )0.5(\(2021\) )0.5([27] )0.6(\023\030\024\020\027\024)]TJ 0 Tw (-)Tj 0.158 Tw -11.051 -1.218 Td (\f\021\017\004\036\f\022\024\036 \027\026\004\036\027\017\036 \020\035\031\ \002\017\027\t \023\024\007\f\035\017\017\f\021\024\005 \017\027\r\026\ \017\017 )Tj 0.012 Tw T* (\017\031\004\026\035\024\f\034 \r)Tj /Span<>> BDC ( )Tj EMC (\026\r\017\f\017\n\024\f\021\017 \024\021 \f\023\024\f\024\002\026 \017\ \n\036\030\036\027\017\016 \r)Tj /Span<>> BDC ( )Tj EMC (\023\024)Tj 0 Tw (-)Tj 0.367 Tw T* (\035\017\023\024\r\017\007\027\t\b \026\007\036\027\024\022\026\030\006\017\ \027\024\n\026\b \021\024\035\f\021\024\005 \022\017\001\022\017 \030\230\ 1 )Tj 0.079 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC (\253\027\024\032\022\036\273 \017)Tj /Span<>> BDC ( )Tj EMC (\027\026 \001\017\030\024\022\024\n \024\f\027\024\r\026\027\017\017. \202\ \r\021\024\030\t \021\026\022\032\036 )Tj 0.298 Tw T* [(\024\021\n\036\004\026\033\021, \004\021\024 \017\f\023\024\035\034\024\ \r\026\027\017\036 \2531000 \242m r)-22(ule\273 \022\026\022 )]TJ 0.13 Tw T* (\024\007\027\024\020\024 \017)Tj /Span<>> BDC ( )Tj EMC [(\024\f\027\024\r\027\t\b )0.5(\023\030\036\007\017\022\021\024\030\024\r \n\036\021\026\f\021\026\017\ \030\024\r\026\027\017\016 )]TJ 0.293 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC 1.499 0 Td [(\023\030\026\022\021\017\022\036 )0.5(\024\002\024\027\026\004\017\035\024 )0.5(\007\r\036 )0.5(\024\f\027\024\r\027\t\036 )0.6(\023\030\024\002\035\036\n\t: )]TJ 0.199 Tw -1.499 -1.218 Td (\r\024\f\023\030\024\017\r\024\007\017\n\024\f\021\034, \022\024\021\024\ \030\026\016 \027\026\023\030\016\n\031\033 \026\r\017\f\036\035\026 \024\ \021 )Tj -0.009 Tw T* (\n\036\021\024\007\017\022\017 \017\n\036\030\036\027\017\016, \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\002\f\021\r\036\027\027\024 \023\030\024\020\027\024\f\021\017\004\ \036\f\022\024\020\024 )Tj 0.051 Tw T* (\027\026\004\036\027\017\016 \007\026\027\027\024\020\024 \023\026\030\026\ \n\036\021\030\026. \215\030\024\r\036\007\036\027\027\024\036 \017\f\f\035\ \036\007\024)Tj 0 Tw (-)Tj 0.153 Tw T* (\r\026\027\017\036 \023\024\022\026\026\035\024, \004\021\024 \020\035\031\ \002\017\027\026 \023\024\007\f\035\017\017\f\021\024\005 \017\027\r\026\ \017\017 )Tj 0.07 Tw T* (\027\036 \017\n\036\036\021 \f\026\n\024\f\021\024\016\021\036\035\034\027\ \024\020\024 \023\030\024\020\027\024\f\021\017\004\036\f\022\024\020\024\ \027\026\004\036)Tj 0 Tw (-)Tj 0.067 Tw T* [(\027\017\016, )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC [(\021\024 \r\030\036\n\016 \022\026\022 )0.5(\020\017\f\021\024\035\024\020\017\004\036\f\022\017\036 )0.5(\b\026\030\026\022\021\036\030\017\f\021\017\022\017 )]TJ 0.013 Tw T* (\024\023\031\b\024\035\017 \(\035\017\n\235\024\r\026\f\022\031\035\016\030\ \027\026\016 \017\027\r\026\017\016 \017)Tj /Span<>> BDC ( )Tj EMC (\r\t\f\024\022\017\005 \024\023\031)Tj 0 Tw (-)Tj 0.124 Tw T* (\b\024\035\036\r\t\005 \002\026\007\007\017\027\020 Bd2/3\) \002\t\035\017\ \007\024\f\021\024\r\036\030\027\024 \026\f\f\024\006\017\017)Tj 0 Tw (-)Tj T* (\030\024\r\026\027\t \f)Tj /Span<>> BDC ( )Tj EMC (\n\036\021\026\f\021\026\026\n\017 \r)Tj /Span<>> BDC ( )Tj EMC (\035\017\n\235\024\031\035\t.)Tj T* (\200 \024\002\024\030\036 Ichimasa)Tj /Span<>> BDC ( )Tj EMC (K. \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. \(2022\) [18] \024\021\n\036\004\026\036\021\f\016, )Tj 0.222 Tw T* (\004\021\024 \020\035\031\002\017\027\026 \023\024\007\f\035\017\017\f\021\ \024\005 \017\027\r\026\017\017 \016\r\035\016\036\021\f\016 \002\024\035\ \036\036 )Tj 0.24 Tw T* (\f\035\026\002\t\n \023\030\036\007\017\022\021\024\030\024\n \n\036\021\ \026\f\021\026\017\030\024\r\026\027\017\016 \023\024)Tj /Span<>> BDC ( )Tj EMC (\f\030\026\r\027\036)Tj 0 Tw (-)Tj 0.075 Tw T* (\027\017\033 \f)Tj /Span<>> BDC ( )Tj EMC (\020\017\f\021\024\035\024\020\017\004\036\f\022\017\n\017 \b\026\030\026\ \022\021\036\030\017\f\021\017\022\026\n\017 \024\023\031\b\024\035\017.\ )Tj 0.173 Tw T* (\207\024\035\036\036 \021\024\020\024, \023\024\007\004\036\030\022\017\r\ \026\036\021\f\016, \004\021\024 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\020\035\031\002\017\027\036 \017\027\r\026)Tj 0 Tw (-)Tj 0.115 Tw T* (\017\017 \030\2301b \(\020\035\031\002\024\022\026\016 \023\024\007\f\035\ \017\017\f\021\026\016 \017\027\r\026\017\016, \f\024\020\035\026\f\027\ \024 )Tj 0.106 Tw T* (\016\023\024\027\f\022\024\005 \022\035\026\f\f\017\235\017\022\026\006\017\ \017\) \017)Tj /Span<>> BDC ( )Tj EMC (\024\021\f\031\021\f\021\r\017\017 \007\030\031\020\017\b \235\026\022)Tj 0 Tw (-)Tj -0.008 Tw T* (\021\024\030\024\r \030\017\f\022\026 \004\026\f\021\024\021\026 \n\036\021\ \026\f\021\026\017\030\024\r\026\027\017\016 \027\036 \023\030\036\r\t\001\ \026\035\026 )Tj 0.081 Tw T* [(1,2\2261,9%, )0.5(\004\021\024 )0.5(\023\024\r\024\035\016\036\021 )0.6(\030\026\f\f\n\026\021\030\017\r\026\021\034 )0.6(\021\026\022\017\036 )0.5(\f\035\031\004\026\017 )]TJ 0.381 Tw T* (\022\026\022 \024\023\031\b\024\035\017 \f)Tj /Span<>> BDC ( )Tj EMC (\027\017\022\017\n \030\017\f\022\024\n \n\036\021\026\f\021\026\017\030\ \024\r\026\027\017\016. )Tj 0.175 Tw T* (\202\r\021\024\030\t \024\021\n\036\004\026\033\021, \004\021\024 \022\035\ \017\027\017\004\036\f\022\026\016 \024\006\036\027\022\026 \020\035\031\ \002\017\027\t )Tj 0.003 Tw T* [(\017\027\r\026\017\017 )0.6(\r)]TJ /Span<>> BDC ( )Tj EMC 4.374 0 Td [(\f\024\r\024\022\031\023\027\024\f\021\017 )0.6(\f)]TJ /Span<>> BDC ( )Tj EMC 6.572 0 Td [(\007\030\031\020\017\n\017 )0.6(\020\017\f\021\024\035\024\020\017\004\036\f\022\017\n\017 )]TJ 0.278 Tw -10.946 -1.218 Td [(\023\026\030\026\n\036\021\030\026\n\017 \023\024\r\024\035\016\036\021\ \017\002\036\032\026\021\034 )0.5(\017\002\t\021\024\004\027\024\020\024 \b\017)]TJ 0 Tw (-)Tj 0.031 Tw T* (\030\031\030\020\017\004\036\f\022\024\020\024 \035\036\004\036\027\017\016\ \023\030\017\n\036\030\027\024 \r)Tj /Span<>> BDC ( )Tj EMC (\021\030\036\021\017 \f\035\031\004\026\036\r \025\217\217 )Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 0 Tw 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\206)10(\002\036\033 \035\030\032\003\033)30(\n)42(\032)-21(\230\033\241)]TJ 57.136 0 Td (REVIEW)Tj /T1_2 1 Tf 25 0 0 25 505.5644 56.0378 Tm (179)Tj ET endstream endobj 1111 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 70.936 724.8299 Tm (\023\023\034\226\034\022\031\034)Tj 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0 Tc 0.246 Tw 10 0 0 10 70.8661 700.4739 Tm (\025\024\035\024\030\036\022\021\026\035\034\027\t\005 \030\026\022 \(\025\ \217\217\) \r\b\024\007\017\021 \r)Tj /Span<>> BDC ( )Tj EMC (\021\030\024\005\022\031 \f\026\n\t\b )Tj 0.78 Tw 0 -1.218 TD (\030\026\f\023\030\024\f\021\030\026\027\036\027\027\t\b \035\024\022\026\ \004\036\f\021\r\036\027\027\t\b \027\024\r\024\024\002\030\026\024)Tj 0 Tw (-)Tj 0.142 Tw T* (\r\026\027\017\005, \027\026)Tj /Span<>> BDC ( )Tj EMC (\007\024\035\033 \022\024\021\024\030\024\020\024 \023\030\017\b\024\007\ \017\021\034\f\016 \023\024\030\016\007\022\026 10% )Tj 0.109 Tw T* (\r\f\036\b \f\035\031\004\026\036\r \030\026\022\026, \017)Tj /Span<>> BDC ( )Tj EMC (\r\021\024\030\026\016 \023\024)Tj /Span<>> BDC ( )Tj EMC (\027\026\004\017\n\024\f\021\017 \023\030\017\004\017\027\026 )Tj 0.214 Tw T* (\f\n\036\030\021\027\024\f\021\017 \024\021 \030\026\022\026 \r)Tj /Span<>> BDC ( )Tj EMC (\n\017\030\036 [1,2]. \200\027\036\007\030\036\027\017\036 \f\022\030\017\ )Tj 0 Tw (-)Tj 0.167 Tw 0 -1.218 TD [(\027\017\027\020\024\r\t\b \023\030\024\020\030\026\n\n \031\r\036\035\017\ \004\017\035\024 )0.5(\004\026\f\021\024\021\031 \007\017\026\020\027\024\f\021\017\022\017 )]TJ 0.274 Tw 0 -1.218 TD (\030\026\027\027\036\020\024 \025\217\217, \022\024\021\024\030\t\005 \f\ \024\f\021\026\r\035\016\036\021 25\22640% \024\021 \r\f\036\b )Tj 0.037 Tw T* (\f\035\031\004\026\036\r, \024\002\027\026\030\031\032\036\027\027\t\b \023\ \030\017)Tj /Span<>> BDC ( )Tj EMC (\220\027\007\024\f\022\024\023\017\004\036\f\022\024\n \017\f\f\035\036)Tj 0 Tw (-)Tj -0.025 Tw T* (\007\024\r\026\027\017\017, \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\n \004\026\f\021\024\021\026 \007\017\026\020\027\024\f\021\ \017\022\017 \n\026\035\017\020\027\017\017\030\024)Tj 0 Tw (-)Tj 0.078 Tw T* [(\r\026\027\027\t\b )0.6(\023\024\035\017\023\024\r, )0.5(\023\024)]TJ /Span<>> BDC ( )Tj EMC 8.605 0 Td [(\007\026\027\027\t\n )0.5(\022\030\031\023\027\036\005\001\017\b )0.6(\f\022\030\017\027\017\027\020\024)]TJ 0 Tw (-)Tj 0.006 Tw -8.605 -1.218 Td [(\r\t\b )0.5(\017\f\f\035\036\007\024\r\026\027\017\005, )0.5(\031\r\036\035\017\004\017\035\026\f\034 )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC 14.105 0 Td [(5% )0.5(\007\024)]TJ /Span<>> BDC ( )Tj EMC 2.731 0 Td [(17% )0.5([1,3\2265]. )]TJ 0.413 Tw -16.836 -1.218 Td (\224\024\r\030\036\n\036\027\027\t\036 \220\027\007\024\f\022\024\023\017\ \004\036\f\022\017\036 \n\036\021\024\007\t \023\024\r\024\035\016\033\021\ )Tj 0.527 Tw 0 -1.218 TD (\031\007\026\035\016\021\034 \220\023\017\021\036\035\017\026\035\034\027\ \t\036 \027\024\r\024\024\002\030\026\024\r\026\027\017\016 \023\030\016\ \n\024\005 )Tj 0.143 Tw 0 -1.218 TD (\017)Tj /Span<>> BDC ( )Tj EMC (\024\002\024\007\024\004\027\024\005 \022\017\001\022\017 \f)Tj /Span<>> BDC ( )Tj EMC (\017\027\r\026\017\036\005, \024\020\030\026\027\017\004\036\027\027\024\ \005 \023\024\007)Tj 0 Tw (-)Tj 0.213 Tw 0 -1.218 TD (\f\035\017\017\f\021\024\005 \024\f\027\024\r\024\005, \027\036 \022\024\ \n\023\030\024\n\036\021\017\030\031\016 \024\027\022\024\035\024\020\017\ \004\036)Tj 0 Tw (-)Tj 0.112 Tw 0 -1.218 TD (\f\022\017\036 \030\036\031\035\034\021\026\021\t \017)Tj /Span<>> BDC ( )Tj EMC (\024\002\036\f\023\036\004\017\r\026\016 \024\030\020\026\027\024\f\024\b\ \030\026\027\016\033\013\036\036 )Tj 0.136 Tw 0 -1.218 TD (\035\036\004\036\027\017\036. \210\f\027\024\r\027\024\005 \023\030\024\002\ \035\036\n\024\005, \022\024\021\024\030\031\033 \023\030\017\b\024\007\017\ \021\f\016 )Tj 0.032 Tw 0 -1.218 TD (\030\036\001\026\021\034 \022\035\017\027\017\006\017\f\021\026\n \023\024\ \f\035\036 \035\024\022\026\035\034\027\024\020\024 \031\007\026\035\036\ \027\017\016 \025\217\217 )Tj 0.014 Tw T* (\030\2301, \016\r\035\016\036\021\f\016 \024\006\036\027\022\026 \030\017\ \f\022\026 \n\036\021\026\f\021\026\017\030\024\r\026\027\017\016 \024\023\ \031\b\024)Tj 0 Tw (-)Tj -0.004 Tw 0 -1.218 TD (\035\017 \r)Tj /Span<>> BDC ( )Tj EMC 1.924 0 Td [(\030\036\020\017\024\027\026\030\027\t\036 )0.5(\035\017\n\235\026\021\017\004\036\f\022\017\036 )0.5(\031\035\t, \004\026\f\021\024\021\026 )0.5(\022\024\021\024)]TJ 0 Tw (-)Tj -1.924 -1.218 Td (\030\t\b \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\025\217\217 \2301 \022\024\035\036\002\035\036\021\f\016 \024\021 2% \007\ \024)Tj /Span<>> BDC ( )Tj EMC (23% [6\2268].)Tj 0.16 Tw 0 -1.218 TD (\217\036\001\036\027\017\036 \024)Tj /Span<>> BDC ( )Tj EMC (\027\036\024\002\b\024\007\017\n\024\f\021\017 \030\036\036\022\006\017\ \017 \021\024\035\f\021\024\005 \022\017\001\022\017 )Tj 0.103 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC [(\026\007\036\022\r\026\021\027\024\005 \035\017\n\235\026\007\036\027\220\ \022\021\024\n\017\036\005 \(\021.\027. com)10(ple)-12(t)-32(ion or )]TJ 0.202 Tw T* [(sal)30(v)-15(a)-17(ge sur)-31.9(ger)-24(y)]TJ /Span<>> BDC ( )Tj EMC (\227 \253\024\023\036\030\026\006\017\016 \f\023\026\f\036\027\017\016\273\ \), \f\024\020\035\026\f\027\024 )Tj 0.307 Tw T* (\007\036\005\f\021\r\031\033\013\017\n \030\036\022\024\n\036\027\007\026\ \006\017\016\n, \023\030\017\027\017\n\026\036\021\f\016 \027\026)Tj /Span<>> BDC ( )Tj EMC (\024\f)Tj 0 Tw (-)Tj 0.232 Tw T* (\027\024\r\026\027\017\017 \n\024\030\235\024\035\024\020\017\004\036\f\022\ \017\b \b\026\030\026\022\021\036\030\017\f\021\017\022 \035\024\022\026\ \035\034\027\024 )Tj 0.366 Tw T* (\031\007\026\035\036\027\027\024\005 \024\023\031\b\024\035\017. \200)Tj /Span<>> BDC ( )Tj EMC (\027\026\f\021\024\016\013\036\036 \r\030\036\n\016 \027\036\002\035\026\ \020\024)Tj 0 Tw (-)Tj 0.092 Tw T* (\023\030\017\016\021\027\t\n\017 \n\024\030\235\024\035\024\020\017\004\036\ \f\022\017\n\017 \023\030\017\027\026\022\026\n\017 \024\023\031\b\024\035\ \017, )Tj 0.088 Tw T* (\f\r\016\026\027\027\t\n\017 \f)Tj /Span<>> BDC ( )Tj EMC (\r\t\f\024\022\017\n \030\017\f\022\024\n \030\026\r\017\021\017\016 \n\ \036\021\026\f\021\026\024\r, )Tj 0.457 Tw T* [(\f\004\017\021\026\033\021\f\016 )0.6(\027\017\022\026\016 )0.5(\007\017\235\235\036\030\036\027\006\017\030\024\r\022\026 )0.5(\026\007\036\027\024\022\026\030\006\017)]TJ 0 Tw (-)Tj 0.275 Tw T* (\027\024\n\t, \r\022\035\033\004\026\016 \024\f\024\002\t\036 \021\017\023\ \t: \023\036\030\f\021\027\036\r\017\007\027\024\022\035\036\021\024\004\ )Tj 0 Tw (-)Tj 0.108 Tw T* (\027\t\005 \017)Tj /Span<>> BDC ( )Tj EMC [(\n\031\006\017\027\024\027\t\005 \030\026\022, \020\035\031\002\024\022\ \026\016 \017\027\r\026\017\016 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC (\023\024\007\f\035\017)Tj 0 Tw (-)Tj 0.235 Tw T* (\017\f\021\t\005 \f\035\024\005 \(>)Tj /Span<>> BDC ( )Tj EMC (1 \n\n\), \027\026\035\017\004\017\036 \035\017\n\235\024\r\026\f\022\031\ \035\016\030\027\024\005 )Tj 0.131 Tw T* [(\017\027\r\026\017\017 )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC 4.674 0 Td [(\023\030\017\027\026\022\024\r )0.5(\253\023\024\004\022\024\r\026\027\017\016\273 )0.5(\024\023\031\b\024\035\017 )0.6(\(tumor )]TJ 0.054 Tw -4.674 -1.218 Td (budding\), \022\024\021\024\030\t\036 \r\022\035\033\004\036\027\t \r)Tj /Span<>> BDC ( )Tj EMC (\024\f\027\024\r\027\t\036 \027\026\006\017\024\027\026\035\034)Tj 0 Tw (-)Tj 0.051 Tw T* (\027\t\036 \017)Tj /Span<>> BDC ( )Tj EMC (\n\036\032\007\031\027\026\030\024\007\027\t\036 \030\031\022\024\r\024\007\ \f\021\r\026 \023\024)Tj /Span<>> BDC ( )Tj EMC (\035\036\004\036\027\017\033 \025\217\217. )Tj 0.117 Tw T* (\202\007\036\027\024\022\026\030\006\017\027\024\n\026 \030\2301 \f)Tj /Span<>> BDC ( )Tj EMC (\027\026\035\017\004\017\036\n \035\033\002\024\020\024 \017)Tj /Span<>> BDC ( )Tj EMC (\031\022\026\026\027)Tj 0 Tw (-)Tj 0.411 Tw T* [(\027\t\b )0.5(\027\036\002\035\026\020\024\023\030\017\016\021\027\t\b )0.6(\023\030\024\020\027\024\f\021\017\004\036\f\022\017\b )0.6(\023\030\017\027\026\022\024\r )]TJ -0.041 Tw T* (\030\026\f\f\n\026\021\030\017\r\026\036\021\f\016 \022\026\022 \017\n\036\ \033\013\026\016 \r\t\f\024\022\017\005 \030\017\f\022 \n\036\021\026\f\021\ \026)Tj 0 Tw (-)Tj 0.077 Tw T* (\017\030\024\r\026\027\017\016. \224\024\024\021\r\036\021\f\021\r\036\027\ \027\024, \220\027\007\024\f\022\024\023\017\004\036\f\022\024\036 \031\007\ \026\035\036)Tj 0 Tw (-)Tj 0.135 Tw T* (\027\017\036 \n\024\032\036\021 \030\026\f\f\n\026\021\030\017\r\026\021\ \034\f\016 \022\026\022 \030\026\007\017\022\026\035\034\027\t\005 \n\036\ \021\024\007 )Tj -0.01 Tw 0 -1.218 TD (\035\036\004\036\027\017\016 \025\217\217 \2301 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\031\f\035\024\r\017\017 \024\021\f\031\021\f\021\r\017\016 \235\026\022\ \021\024\030\024\r \030\017)Tj 0 Tw (-)Tj 0.055 Tw 0 -1.218 TD [(\f\022\026 )0.5(\n\036\021\026\f\021\026\017\030\024\r\026\027\017\016 )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC 10.287 0 Td [(\r\024\r\035\036\004\036\027\017\016 )0.6(\022\030\026\036\r )0.5(\030\036\036\022\006\017\017, )]TJ 0.423 Tw -10.287 -1.218 Td (\022\024\021\024\030\t\036 \024\023\030\036\007\036\035\016\033\021\f\016\ \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\023\026\021\024\n\024\030\235\024\035\024\020\017\004\036\f\022\024\n )Tj 0 Tw 0 -1.218 TD (\017\f\f\035\036\007\024\r\026\027\017\017 [9\22615].)Tj 0.174 Tw T* (\210\007\027\026\022\024 \023\030\017\n\036\027\036\027\017\036 \007\026\ \027\027\t\b \022\030\017\021\036\030\017\036\r \027\026)Tj /Span<>> BDC ( )Tj EMC (\023\030\026\022\021\017\022\036 )Tj 0.257 Tw 0 -1.218 TD [(\023\024\022\026\026\035\024, )0.5(\004\021\024 \031)]TJ /Span<>> BDC ( )Tj EMC [(\002\024\035\034\001\017\027\f\021\r\026 )0.5(\023\026\006\017\036\027\021\024\r )0.5(\023\024\f\035\036 )0.5(\035\024)]TJ 0 Tw (-)Tj 0.036 Tw 0 -1.218 TD [(\022\026\035\034\027\024\020\024 \031\007\026\035\036\027\017\016 )0.5(\025\217\217 )0.5(\2301 \023\024\022\026\026\027\017\016 \022)]TJ /Span<>> BDC ( )Tj EMC (\007\024\023\024\035\027\017\021\036\035\034)Tj 0 Tw (-)Tj 0.126 Tw 0 -1.218 TD [(\027\024\n\031 \b\017\030\031\030\020\017\004\036\f\022\024\n\031 )0.5(\035\036\004\036\027\017\033 \023\030\036\r\t\001\036\027\t)]TJ /Span<>> BDC ( )Tj EMC 18.518 0 Td ([16\22623]. )Tj 0.148 Tw -18.518 -1.218 Td (\230\026\022, \023\024)Tj /Span<>> BDC ( )Tj EMC [(\007\026\027\027\t\n Z)10(af)-56(f)16(al)30(on)]TJ /Span<>> BDC ( )Tj EMC (D. \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. [19], \n\036\021\026\f\021\026\t )Tj -0.003 Tw 0 -1.218 TD (\r)Tj /Span<>> BDC ( )Tj EMC (\035\017\n\235\024\031\035\026\b \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\025\217\217 \2301 \024\002\027\026\030\031\032\017\r\026\033\021\f\016 \ \r)Tj /Span<>> BDC ( )Tj EMC (2\22610,5% )Tj 0.57 Tw 0 -1.218 TD (\f\035\031\004\026\036\r \023\024\f\035\036 \007\024\023\024\035\027\017\ \021\036\035\034\027\024\005 \030\036\036\022\006\017\017 \022\017\001\022\ \017 )Tj 0.103 Tw 23.244 64.543 Td (\f)Tj /Span<>> BDC ( )Tj EMC (\030\036\020\017\024\027\026\030\027\t\n\017 \035\017\n\235\024\031\035\ \026\n\017. Choi Y. \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. [20] )Tj 0.242 Tw T* (\023\024\022\026\026\035, \004\021\024 \023\024)Tj /Span<>> BDC ( )Tj EMC (\f\031\013\036\f\021\r\031\033\013\017\n \022\030\017\021\036\030\017\016\ \n 70\22680% )Tj 0.024 Tw T* (\f\035\031\004\026\036\r \035\024\022\026\035\034\027\024 \031\007\026\035\ \036\027\027\t\b \024\023\031\b\024\035\036\005 \030\026\f\006\036\027\017\ \r\026\033\021)Tj 0 Tw (-)Tj 0.026 Tw T* [(\f\016, \022\026\022 \017\n\036\033\013\017\036 \r\t\f\024\022\017\005 \030\ \017\f\022 \(high r)-37(isk\) \n\036\021\026\f\021\026\017)]TJ 0 Tw (-)Tj 0.082 Tw T* (\030\024\r\026\027\017\016, \024\007\027\026\022\024, \023\024\f\035\036\ \007\024\023\024\035\027\017\021\036\035\034\027\024\020\024 \b\017\030\ \031\030\020\017\004\036)Tj 0 Tw (-)Tj 0.052 Tw T* (\f\022\024\020\024 \035\036\004\036\027\017\016, \r)Tj /Span<>> BDC ( )Tj EMC (\023\024\007\026\r\035\016\033\013\036\n \002\024\035\034\001\017\027\f\021\ \r\036 \f\035\031\004\026\036\r )Tj -0.038 Tw T* (\(>)Tj /Span<>> BDC ( )Tj EMC (90%\) \n\036\021\026\f\021\026\t \r)Tj /Span<>> BDC ( )Tj EMC (\035\017\n\235\024\031\035\026\b \027\036 \024\002\027\026\030\031\032\017\ \r\026\033\021\f\016. )Tj 0.023 Tw 0 -1.218 TD (\215\024\007\024\002\027\t\036 \030\036\031\035\034\021\026\021\t \023\030\ \017\r\024\007\016\021\f\016 \r)Tj /Span<>> BDC ( )Tj EMC (\024\002\024\030\026\b \017)Tj /Span<>> BDC ( )Tj EMC (\n\036\021\026\026)Tj 0 Tw (-)Tj 0.034 Tw 0 -1.218 TD (\027\026\035\017\026\b Bosch)Tj /Span<>> BDC ( )Tj EMC [(S. \(2013\), Bea)15(t)17(on)]TJ /Span<>> BDC ( )Tj EMC (C. \(2013\), Ebbeh\370j)Tj /Span<>> BDC ( )Tj EMC (A. )Tj -0.011 Tw T* [(\(2021\), Z)66(w)-12(a)-17(ger)]TJ /Span<>> BDC ( )Tj EMC (L. \(2022\) [7,21\22623]. \215\030\024\002\035\036\n\026 \023\036\030\036\ \035\036)Tj 0 Tw (-)Tj 0.084 Tw T* [(\004\036\027\027\024\f\021\017 \(over-tr)-24(ea)15.1(tment\) \027\026\004\017\021\036\035\034\027\024\005 \004\026\f\021\017\ \021\026\022\017\b )]TJ 0.114 Tw T* [(\023\026\006\017\036\027\021\024\r, )0.5(\023\030\017\r\024\007\016\013\036\005, )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC [(\f\r\024\033 \024\004\036\030\036\007\034, )0.5(\022)]TJ /Span<>> BDC ( )Tj EMC (\031\r\036\035\017\004\036)Tj 0 Tw (-)Tj 0.213 Tw 0 -1.218 TD [(\027\017\033 \f\021\024\017\n\024\f\021\017 \035\036\004\036\027\017\016\ , \022\024\035\017\004\036\f\021\r\031 )0.5(\023\024\f\035\036\024\023\036\030\026\006\017)]TJ 0 Tw (-)Tj -0.009 Tw 0 -1.218 TD [(\024\027\027\t\b )0.5(\024\f\035\024\032\027\036\027\017\005 )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC 8.865 0 Td [(\f\n\036\030\021\027\024\f\021\017, )0.6(\f\027\017\032\036\027\017\033 )0.5(\022\026\004\036\f\021\r\026 )]TJ 0.088 Tw -8.865 -1.218 Td (\032\017\027\017 \023\026\006\017\036\027\021\024\r \f\021\024\017\021 \ \024\f\024\002\036\027\027\024 \024\f\021\030\024 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\035\024\022\026\035\017)Tj 0 Tw (-)Tj T* (\026\006\017\017 \024\023\031\b\024\035\036\005 \2301 \r)Tj /Span<>> BDC ( )Tj EMC (\023\030\016\n\024\005 \022\017\001\022\036.)Tj /T1_2 1 Tf 0.03 Tc 1.187 Tw 0 -2.436 TD [(\t\033\034\013\020\034\024\035\022\005\016\024\021\034\016 \031\020\037\005\ \016\020\022\016 \006\034\033\017\034\027\034\013\022\005\016\024\021\022\ \002)30( )]TJ 0 Tc 0 Tw 0 -1.218 TD (\f\033\022\031\020\037\021\034\036)Tj /T1_1 1 Tf 0.043 Tw 0 -1.218 TD (\215\030\024\020\027\024\f\021\017\004\036\f\022\024\036 \027\026\004\036\ \027\017\036 \027\036\002\035\026\020\024\023\030\017\016\021\027\t\b \n\ \024\030\235\024)Tj 0 Tw (-)Tj -0.017 Tw T* [(\035\024\020\017\004\036\f\022\017\b )0.6(\023\030\017\027\026\022\024\r )0.5(\017\031\004\026\035\024\f\034 )0.6(\027\026)]TJ /Span<>> BDC ( )Tj EMC 15.028 0 Td [(\023\030\024\021\016\032\036\027\017\017 )0.6(\007\035\017)]TJ 0 Tw (-)Tj 0.064 Tw -15.028 -1.218 Td (\021\036\035\034\027\024\020\024 \r\030\036\n\036\027\017 \r)Tj /Span<>> BDC ( )Tj EMC (\n\027\024\020\024\004\017\f\035\036\027\027\t\b \017\f\f\035\036\007\024\ \r\026\027\017\016\b, )Tj 0.004 Tw 0 -1.218 TD (\030\036\031\035\034\021\026\021\t \022\024\021\024\030\t\b \002\t\035\017\ \027\036\024\007\027\024\027\026\004\027\t. \025\030\024\n\036 \021\024\ \020\024, )Tj 0.049 Tw 0 -1.218 TD (\023\030\024\020\027\024\f\021\017\004\036\f\022\024\036 \027\026\004\036\ \027\017\036 \027\036\022\024\021\024\030\t\b \023\030\017\027\026\022\024\ \r \n\036)Tj 0 Tw (-)Tj 0.279 Tw T* [(\027\016\035\024\f\034 )0.6(\023\024)]TJ /Span<>> BDC ( )Tj EMC 4.859 0 Td [(\n\036\030\036 )0.5(\027\026\022\024\023\035\036\027\017\016 )0.6(\007\026\027\027\t\b, )0.6(\023\030\036\007\035\026\020\026\035\017\f\034 )]TJ 0.322 Tw -4.859 -1.218 Td (\027\024\r\t\036 \023\030\036\007\017\022\021\024\030\t, \022\024\021\024\ \030\t\036 \r\022\035\033\004\026\035\017\f\034 \r)Tj /Span<>> BDC ( )Tj EMC (\027\026\006\017\024)Tj 0 Tw (-)Tj -0.002 Tw T* (\027\026\035\034\027\t\036 \017/\017\035\017 \n\036\032\007\031\027\026\030\ \024\007\027\t\036 \030\031\022\024\r\024\007\f\021\r\026. \200)Tj /Span<>> BDC ( )Tj EMC (\f\r\016\017 )Tj 0.065 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\220\021\017\n, \030\036\022\024\n\036\027\007\031\036\n\t\036 \007\035\016\ \024\006\036\027\022\017 \030\017\f\022\026 \n\036\021\026\f\021\026\017\ )Tj 0 Tw (-)Tj 0.456 Tw T* [(\030\024\r\026\027\017\016 )0.5(\n\024\030\235\024\035\024\020\017\004\036\f\022\017\036 )0.6(\023\030\017\027\026\022\017 )0.6(\030\026\035\017\004\026\033\021\f\016 )]TJ 0.147 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\027\026\006\017\024\027\026\035\034\027\t\b \017)Tj /Span<>> BDC ( )Tj EMC (\n\036\032\007\031\027\026\030\024\007\027\t\b \022\035\017\027\017\004\036\ \f\022\017\b \030\031)Tj 0 Tw (-)Tj 0.085 Tw T* [(\022\024\r\024\007\f\021\r\026\b \(Jap)32(anese S)-16(o)-16(c)-24(ie)-12(t)-9.9(y for Cancer of)]TJ /Span<>> BDC ( )Tj EMC [(t)-13(he Col)30(on )]TJ 0.302 Tw T* [(and R)13(ec)-16(tum \(JSCCR 2019\); Na)15(t)-32(ional Com)10(p)25(r)-24(ehensi)-16(ve )]TJ 0.357 Tw T* [(Cancer )0.5(Ne)-12(t)-32(w)-13.9(or)-24(k )0.5(\(NCCN2021\); )0.5(Eur)-32(opean )0.6(S)-16(o)-16(c)-24(ie)-12(t)-10(y )0.5(for )]TJ 0.595 Tw T* [(Medical Oncol)30(o)-16(g)16(y \(ESMO2020\); Eur)-32(opean S)-16(o)-16(c)-24(ie)-12(t)-9.9(y )]TJ 0.191 Tw T* (of)Tj /Span<>> BDC ( )Tj EMC [(Gastr)-31.9(ointest)-32(inal End)-15.9(oscopy \(ESGE2019\); Amer)-37(ican )]TJ 0.374 Tw T* [(S)-16(o)-16(c)-24(ie)-12(t)-9.9(y for Gastr)-31.9(ointest)-32(inal End)-16(oscopy \(A)35(SGE2020\) )]TJ 0 Tw T* ([11,12,14,15,24].)Tj -0.007 Tw T* (\213\f\035\017 \024\021\027\024\f\017\021\036\035\034\027\024 \021\026\022\ \017\b \020\017\f\021\024\035\024\020\017\004\036\f\022\017\b \023\030\017\ \027\026\022\024\r, )Tj 0.013 Tw T* [(\022\026\022 \f\021\036\023\036\027\034 \007\017\235\235\036\030\036\027\ \006\017\030\024\r\022\017 \024\023\031\b\024\035\017 \(G)20(r)-33(ade\), \035\017\n)]TJ 0 Tw (-)Tj 0.029 Tw T* [(\235\024\r\026\f\022\031\035\016\030\027\026\016 \017\027\r\026\017\016\ \(L)65.1(VI\) \017)]TJ /Span<>> BDC ( )Tj EMC (\253\023\024\004\022\024\r\026\027\017\036\273 \024\023\031\b\024)Tj 0 Tw (-)Tj -0.011 Tw T* [(\035\017 )0.5(\(tumor )0.6(budding\) )0.5(\017\n\036\036\021\f\016 )0.5(\024\023\030\036\007\036\035\036\027\027\t\005 )0.6(\022\024\027\f\036\027\f\031\f )]TJ 0.103 Tw T* (\022\026\022 \023\030\036\007\017\022\021\024\030\024\r \n\036\021\026\f\ \021\026\017\030\024\r\026\027\017\016, \021\024 \020\035\031\002\017\027\ \026 \023\024\007)Tj 0 Tw (-)Tj -0.007 Tw T* (\f\035\017\017\f\021\024\005 \017\027\r\026\017\017 \(DSI\) \r)Tj /Span<>> BDC ( )Tj EMC (\027\026\f\021\024\016\013\036\036 \r\030\036\n\016 \016\r\035\016\036\021\ \f\016 )Tj -0.001 Tw 0 -1.218 TD (\027\026\017\002\024\035\036\036 \027\036\024\007\027\024\027\026\004\027\ \t\n \023\030\017\027\026\022\024\n \r)Tj /Span<>> BDC ( )Tj EMC (\022\026\004\036\f\021\r\036 \235\026\022)Tj 0 Tw (-)Tj 0 -1.218 TD (\021\024\030\026 \030\017\f\022\026 \n\036\021\026\f\021\026\017\030\024\ \r\026\027\017\016 \r)Tj /Span<>> BDC ( )Tj EMC (\035\017\n\235\024\031\035\t.)Tj /T1_2 1 Tf 0 -2.436 TD (\223\027\023\025\022\020\037 \f\034\b\024\027\022\031\022\024\035\034\004\ \022\020\036\037\031\022\022)Tj /T1_1 1 Tf 0.155 Tw 0 -1.218 TD (\224\035\036\007\031\036\021 \024\021\n\036\021\017\021\034, \004\021\024\ \020\035\031\002\017\027\026 \017\027\r\026\017\017 \r)Tj /Span<>> BDC ( )Tj EMC (\023\024\007\f\035\017\017)Tj 0 Tw (-)Tj 0.094 Tw 0 -1.218 TD (\f\021\t\005 \f\035\024\005 \027\026)Tj /Span<>> BDC ( )Tj EMC 5.835 0 Td [(\023\030\024\021\016\032\036\027\017\017 )0.5(\023\024\f\035\036\007\027\017\b )0.5(\007\r\031\b \007\036\f\016\021\017\035\036)]TJ 0 Tw (-)Tj 0.105 Tw -5.835 -1.218 Td (\021\017\005 \030\026\f\f\n\026\021\030\017\r\026\035\026\f\034 \022\026\ \022 \024\007\017\027 \017)Tj /Span<>> BDC ( )Tj EMC (\024\f\027\024\r\027\t\b \023\030\036\007\017\022)Tj 0 Tw (-)Tj 0.304 Tw 0 -1.218 TD [(\021\024\030\024\r )0.5(\n\036\021\026\f\021\026\017\030\024\r\026\027\017\016 )0.6(\r)]TJ /Span<>> BDC ( )Tj EMC 11.985 0 Td [(\035\017\n\235\024\031\035\t )0.6(\023\030\017)]TJ /Span<>> BDC ( )Tj EMC 7.287 0 Td (\025\217\217T1. )Tj 0.213 Tw -19.272 -1.218 Td (\200\023\036\030\r\t\036 \220\021\024\021 \023\030\017\027\026\022 \002\ \t\035 \r\022\035\033\004\036\027 \r)Tj /Span<>> BDC ( )Tj EMC (\030\031\022\024\r\024\007\f\021\r\024 )Tj 0.276 Tw 0 -1.218 TD (JSCCR \r)Tj /Span<>> BDC ( )Tj EMC (2005)Tj /Span<>> BDC ( )Tj EMC (\020. \023\024\f\035\036 \023\030\024\r\036\007\036\027\027\t\b \n\027\024\ \020\024\006\036\027\021\030\024)Tj 0 Tw (-)Tj 0.079 Tw 0 -1.218 TD [(\r\t\b \017\f\f\035\036\007\024\r\026\027\017\005, \023\024\022\026\026\ \r\001\017\b )0.5(\026\r\017\f\017\n\024\f\021\034 \004\026\f\021\024\021\t )]TJ 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0 Tw 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\206)10(\002\036\033 \035\030\032\003\033)30(\n)42(\032)-21(\230\033\241)]TJ 57.136 0 Td (REVIEW)Tj -57.136 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 2)69(4, \023\0224, 202)23(5)]TJ 43.013 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 2)69(4, \023\0224, 202)23(5)]TJ /T1_4 1 Tf 25 0 0 25 20.8526 56.0378 Tm (178)Tj ET endstream endobj 1108 0 obj [1114 0 R] endobj 1109 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\034\201\025\235\t\016\024\220 \021\022\222\016\201\b\222\016\017)-9.9(\026\021\r\220 \222\201\021\024\016\215\016\215\021\004 \024\025\201\223\ \025\t\025\202\021\f\016\b\017\021 )]TJ 0 -1 TD [(\223\001\017)-10(\026)11(\025\201\025\r \201\021\b\017\001 \024\016\026)11(\001\b)-10(\026)11(\001\213\021\201\025\r\001\215\021\004 \r\022\t\021\024\223\001\026\021\f\ \016\b\017\021\016 \200)31(\213\t\220 )]TJ T* [(\222\201\021\022\017)10(\025\t\025\201\016\017)-10(\026)11(\001\t\214\215\025\024 \201\001\017\016 \0321 \(\025\235\213\025\201 \t\021\ \026)11(\016\201\001\026)-20(\200\201\220\))]TJ 37.237 2 Td [(Pr)20(oblems and pr)20(ospects of\022using morph)11(ological risk factor)20.1(s )]TJ 0.243 -1 Td [(for\022lymph node metastasis in T1 color)31(ectal cancer \(r)31(e)11(vie)11(w\))]TJ ET 0 0 0 1 K 1 j 1 J [0 2.997]0 d /GS1 gs q 1 0 0 1 46.0167 446.141 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 43.0197 446.141 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q [0 2.997]0 d q 1 0 0 1 46.0167 408.9332 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 43.0197 408.9332 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q [0 2.997]0 d q 1 0 0 1 46.0167 186.179 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 43.0197 186.179 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q [0 2.997]0 d q 1 0 0 1 46.0167 158.5711 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 43.0197 158.5711 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q 0 j 0 J q 1 0 0 1 42.5197 104.502 cm 0 0 m 453.543 0 l S Q BT 0 0 0 1 k /T1_1 1 Tf 10 0 0 10 42.5197 724.8299 Tm (https://doi.org/10.33878/2073-7556-2025-24-4-177-187)Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 0.023 Tw 19 0 0 19 45.1596 695.3259 Tm [(\034\201\025\235\t\016\024\220 \021\022)-23.3(\222\016\201\b\222\016\017)-10(\026\021\r\220 \222\201\021\024\016\215\016\215\021\004 \024\025\201\223\ \025\t\025\202\021\f\016\b\017\021 )]TJ 0.795 -1.105 Td [(\223\001\017)-10(\026)11(\025\201\025\r \201\021\b\017\001 \024\016\026)11(\001\b)-10(\026)11(\001\213\021\201\025\r\001\215\021\004 \r\022)-23.3(\t\021\024\223\001\026\021\f\016\b\017\021\016 )]TJ -0.408 -1.105 Td [(\200)31(\213\t\220 \222\201\021\022)-23.3(\017)10(\025\t\025\201\016\017)-10(\026)11(\001\t\214\215\025\024 \201\001\017\016 \0321 \(\025\235\213\025\201 \t\021\ \026)11(\016\201\001\026)-20(\200\201\220\))]TJ 0 0 0 1 k /GS1 gs 0 Tw 14 0 0 14 42.5197 628.822 Tm [(\007\001\207\215\025\r\b\017\001\004\022)-23.2(\036.\n)-31(.)]TJ 0.023 Tw 10 0 0 10 42.5197 611.1527 Tm [(\203\031\206)42(\230 \253\217\007\030\226 \017)10(\025\t\025\222\201\025\017)-9.9(\026)11(\025\t\025\202\021\021 \021\024\016\215\021 \n)-30.9(.\217.\022)-23.3(\033\220\216\021\273 \007\021\215\213\211\201\001\r\001 \033\025\b\b\021\ \021 \(\200\t.\022)-23.2(\013\001\t\004\024\001 \n)-20.9(\211\021\t\004, \211.\022)-23.3(2, \202)62.1(.\022)-23.3(\007\025\b\017\r\001, )]TJ 0 -1.2 TD [(1)125(23)58(423, \033\025\b\b\021\004\))]TJ /T1_1 1 Tf 0.122 Tw 9 0 0 9 90.7087 580.6488 Tm (\n\022\037\013\020\034\024\035\022\021\037 \022)Tj /Span<>> BDC ( )Tj EMC (\027\016\005\016\020\022\016 \033\037\020\020\016\013\034 \r\213\213 \024\ )Tj /Span<>> BDC ( )Tj EMC (\f\034\b\024\027\022\031\022\024\035\034\004 \022\020\036\037\031\022\016\ \004 \(\2021 \r\213\213\) \030\036\027\030\016\035\024\030 \037\021\035\023\ \037\027\003\020\034\004 \022)Tj /Span<>> BDC ( )Tj EMC (\024\027\034\201\020\034\004 )Tj 0.262 Tw 0 -1.111 TD [(\f\033\034\025\027\016\006\034\004 )0.6(\024\034\036\033\016\006\016\020\020\034\004 )0.6(\034\020\021\034\027\034\013\022\022. )0.6(\213\037\024\001\022\033\016\020\022\016 )0.6(\036\034\031\006\034\201\020\034\024\035\016\004 )0.7(\220\020\b\034\024\021\034\f\022\005\016\024\021\022\002 )0.5(\035\016\002\020\034\027\034\013\022\004 )0.6(\f\034\031\036\034\027\030\016\035 )]TJ -0.015 Tw T* (\f\033\034\036\034\b\022\035\003 \034\033\013\037\020\034\024\034\002\033\ \037\020\030\026\235\016\016 \027\016\005\016\020\022\016 \024)Tj /Span<>> BDC ( )Tj EMC (\027\034\021\037\027\003\020\032\006 \023\b\037\027\016\020\022\016\006 \ \034\f\023\002\034\027\022 \024)Tj /Span<>> BDC ( )Tj EMC (\f\034\b\024\027\022\031\022\024\035\034\004 \022\020\036\037\031\022\016\ \004. \240\024\020\034\036\020\034\004 )Tj 0.007 Tw T* (\f\033\034\025\027\016\006\034\004 \036)Tj /Span<>> BDC ( )Tj EMC (\034\033\013\037\020\034\024\034\002\033\037\020\030\026\235\016\006 \027\ \016\005\016\020\022\022 \2021 \r\213\213 \030\036\027\030\016\035\024\030\ \034\035\025\034\033 \f\037\007\022\016\020\035\034\036 \022)Tj /Span<>> BDC ( )Tj EMC (\006\037\021\024\022\006\037\027\003\020\034 \035\034\005\020\037\030 \034\ \007\016\020\021\037 )Tj -0.029 Tw T* (\033\022\024\021\037 \006\016\035\037\024\035\037\031\022\033\034\036\037\ \020\022\030 \034\f\023\002\034\027\022 \036)Tj /Span<>> BDC ( )Tj EMC (\021\037\201\b\034\006 \021\034\020\021\033\016\035\020\034\006 \024\027\ \023\005\037\016. )Tj /Span<>> BDC ( )Tj EMC (\020\037\024\035\034\030\235\016\016 \036\033\016\006\030 \006\034\033\017\ \034\027\034\013\022\005\016\024\021\022\016 \002\037\033\037\021)Tj 0 Tw (-)Tj -0.025 Tw 0 -1.111 TD (\035\016\033\022\024\035\022\021\022 \034\f\023\002\034\027\022 \030\036\ \027\030\026\035\024\030 \034\024\020\034\036\020\032\006\022 \f\033\016\ \b\022\021\035\034\033\037\006\022 \006\016\035\037\024\035\037\031\022\033\ \034\036\037\020\022\030 \f\033\022)Tj /Span<>> BDC ( )Tj EMC (\2021 \r\213\213. \240\b\020\037\021\034 \f\033\022\006\016\020\016\020\022\ \016 )Tj 0.037 Tw 0 -1.111 TD (\033\016\021\034\006\016\020\b\034\036\037\020\020\032\002 \006\034\033\017\ \034\027\034\013\022\005\016\024\021\022\002 \f\033\016\b\022\021\035\034\ \033\034\036 \034\025\034\031\020\037\005\022\027\034 \034\f\033\016\b\016\ \027\016\020\020\032\016 \f\033\034\025\027\016\006\032 \036)Tj /Span<>> BDC ( )Tj EMC (\034\035\025\034\033\016 \f\037\007\022\016\020\035\034\036 )Tj 0.023 Tw T* (\024)Tj /Span<>> BDC ( )Tj EMC (\031\037\036\032\001\016\020\022\016\006 \f\034\021\037\031\037\020\022\004\ \021)Tj /Span<>> BDC ( )Tj EMC (\b\034\f\034\027\020\022\035\016\027\003\020\034\006\023 \002\022\033\023\ \033\013\022\005\016\024\021\034\006\023 \027\016\005\016\020\022\026.)Tj /T1_2 1 Tf 0.01 Tc 0.098 Tw 8 0 0 8 42.5596 495.3795 Tm [(\037\033\016\r\030\025\f\030)5( \026\033\036\025\021:)]TJ /T1_1 1 Tf 0 Tc 0.103 Tw 8.573 0 Td ( \021\034\027\034\033\016\021\035\037\027\003\020\032\004 \033\037\021 \202\ 1, \006\034\033\017\034\027\034\013\022\005\016\024\021\022\016 \017\037\ \021\035\034\033\032 \033\022\024\021\037 \006\016\035\037\024\035\037\031\ \022\033\034\036\037\020\022\030 \036)Tj /Span<>> BDC ( )Tj EMC (\027\022\006\017\034\023\031\027\032, \034\007\016\020\021\037 \033\022\024\ \021\037 \006\016\035\037)Tj 0 Tw (-)Tj 0.023 Tw -8.578 -1.2 Td (\024\035\037\031\022\033\034\036\037\020\022\030 \f\033\022)Tj /Span<>> BDC ( )Tj EMC (\2021 \r\213\213)Tj /T1_2 1 Tf 0.01 Tc 0.018 Tw 0.005 -1.909 Td [(\037\036\035\034\033\032\037\031)5( \032\035\031\030\027\030\026\036\025:)]TJ /T1_1 1 Tf 0 Tc 0.023 Tw 10.401 0 Td ( \037\036\035\034\033\032 \031\037\030\036\027\030\026\035 \034\025 \034\ \035\024\023\035\024\035\036\022\022 \021\034\020\017\027\022\021\035\037\ \022\020\035\016\033\016\024\034\036)Tj /T1_2 1 Tf 0.01 Tc -0.01 Tw -10.401 -1.909 Td (\034\032\035\021\035\026\032\027\036\025\021\035\032\030:)Tj /T1_1 1 Tf 0 Tc 0.023 Tw 8.655 0 Td ( \033\037\025\034\035\037 \036\032\f\034\027\020\016\020\037 \025\016\031\ \024\f\034\020\024\034\033\024\021\034\004 \f\034\b\b\016\033\201\021\022\ )Tj /T1_2 1 Tf 0.033 Tc 0.182 Tw -8.655 -2.617 Td [(\024\033\023)4.7( \022\032\031\032\027\036\025\021\035\032\023:)]TJ /T1_3 1 Tf 0.023 Tc 0.187 Tw 9.354 0 Td ( \204\026\005\027\024\r\f\022\026\016)Tj /Span<>> BDC ( )Tj EMC (\210.\202. \215\030\024\002\035\036\n\t \017)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\f\023\036\022\021\017\r\t \023\030\017\n\036\027\036\027\017\ \016 \n\024\030\235\024\035\024\020\017\004\036\f\022\017\b \235\026\022\ \021\024\030\024\r \030\017\f\022\026 \n\036\021\026\f\021\026\017\030\024\ )Tj 0 Tc 0 Tw (-)Tj 0.023 Tc 0.08 Tw -9.359 -1.2 Td (\r\026\027\017\016 \r)Tj /Span<>> BDC ( )Tj EMC (\035\017\n\235\026\021\017\004\036\f\022\017\036 \031\035\t \023\030\017\ )Tj /Span<>> BDC ( )Tj EMC (\022\024\035\024\030\036\022\021\026\035\034\027\024\n \030\026\022\036 \ \2301 \(\024\002\024\030 \035\017\021\036\030\026\021\031\030\t\). )Tj /T1_1 1 Tf -0.023 Tw (\r\034\027\034\f\033\034\021\035\034\027\034\013\022\030.)Tj /T1_3 1 Tf 0.08 Tw ( 2025; \021.)Tj /Span<>> BDC ( )Tj EMC (24, \223)Tj /Span<>> BDC ( )Tj EMC (4, \f.)Tj /Span<>> BDC ( )Tj EMC [(177\226187.)23( )]TJ -0.023 Tw 0 -1.2 TD (https://doi.org/10.33878/2073-7556-2025-24-4-177-187)Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 0 Tc 0.023 Tw 18 0 0 18 58.7035 382.7639 Tm [(Pr)20(oblems and pr)20(ospects of\022)-23.2(using morph)11(ological risk factor)20(s )]TJ 0.11 -1.167 Td [(for lymph node metastasis in T1 color)31(ectal cancer \(r)31(e)11(vie)11(w\))]TJ 0 0 0 1 k /GS1 gs 0 Tw 14 0 0 14 42.5197 337.26 Tm [(Olga\022)-23.3(A)-30.9(.\022)-23.3(Mainov)10(skay)21(a)]TJ 0.023 Tw 10 0 0 10 42.5197 319.5907 Tm [(R)20(y)21(zhikh National Medical Resear)31(ch Center of\022)-23.3(Colopr)20.1(octology \(Saly)21(ama Adily)21.1(a\022)-23.3(st., 2, Moscow)22(, 1)125(23)58(423, Russia\))]TJ /T1_1 1 Tf 0.055 Tw 9 0 0 9 90.7087 301.0868 Tm [(Diagnostics )0.6(and )0.6(treatment )0.6(of)]TJ /Span<>> BDC ( )Tj EMC 11.777 0 Td [(early )0.6(colorectal )0.6(cancer )0.6(with )0.6(submucosal )0.7(in)10.9(v)16(asion )0.5(\(T1 )0.6(CR)21(C\) )0.6(is )0.5(a)]TJ /Span<>> BDC ( )Tj EMC 24.883 0 Td [(relev)16(ant )0.6(and )0.6(com)16(ple)-15(x )]TJ 0.089 Tw -36.66 -1.111 Td [(p)46(roblem )0.5(of)]TJ /Span<>> BDC ( )Tj EMC [(moder)-13.9(n oncology)32(. )0.5(Adv)16(ancements )0.5(in endoscopic )0.5(techniq)14(ues )0.5(allows for org)12(an-p)46(reser)-41.9(ving treatment with )]TJ 0.04 Tw 0 -1.111 TD [(local remov)16(al of)]TJ /Span<>> BDC ( )Tj EMC [(the tumor with submucosal in)11(v)16(asion. The)]TJ /Span<>> BDC ( )Tj EMC [(main p)46(roblem in org)11.9(an p)46(reser)-42(v)16(ation treatment of)]TJ /Span<>> BDC ( )Tj EMC [(T1 CR)21(C )]TJ 0.123 Tw T* (is patient selection and the)Tj /Span<>> BDC ( )Tj EMC [(most accurate assess)33(ment of)]TJ /Span<>> BDC ( )Tj EMC [(the r)-37(isk of)]TJ /Span<>> BDC ( )Tj EMC [(tumor metastasis in each personal histor)-43(y)32(. )]TJ 0.145 Tw T* [(Cur)-16(rently)42.1(, mor)-18(phological character)-36.9(istics of)]TJ /Span<>> BDC ( )Tj EMC (the tumor are the)Tj /Span<>> BDC ( )Tj EMC [(main p)46(redictors of)]TJ /Span<>> BDC ( )Tj EMC [(metastasis in T1 CR)21(C. How)12(ev)13(er)61(, )]TJ 0.045 Tw 0 -1.111 TD (the)Tj /Span<>> BDC ( )Tj EMC 1.556 0 Td [(use )0.5(of)]TJ /Span<>> BDC ( )Tj EMC 2.665 0 Td [(recommended )0.5(mor)-18(phological )0.5(p)46(redictors )0.6(has identif)-42.9(ied )0.5(cer)-40(tain )0.5(p)46(roblems in )0.5(the)]TJ /Span<>> BDC ( )Tj EMC 30.807 0 Td (selection of)Tj /Span<>> BDC ( )Tj EMC 4.832 0 Td (patients with )Tj 0.023 Tw -39.86 -1.111 Td (an)Tj /Span<>> BDC ( )Tj EMC [(ov)13(erestimation of)]TJ /Span<>> BDC ( )Tj EMC (indications for additional surgical treatment.)Tj /T1_2 1 Tf 0.01 Tc -0.01 Tw 8 0 0 8 42.5596 225.8175 Tm [(KEYW)22(ORDS:)]TJ /T1_1 1 Tf 0 Tc 0.023 Tw 4.948 0 Td [( T1 colorectal cancer)61.1(, mor)-18(phological r)-37(isk factors for lym)16(ph node metastasis, assess)33(ment of)]TJ /Span<>> BDC ( )Tj EMC [(the r)-37(isk of)]TJ /Span<>> BDC ( )Tj EMC [(metastasis in T1 CR)21(C)]TJ /T1_2 1 Tf 0.01 Tc 0.018 Tw -4.948 -1.909 Td [(C)19(ONFL)-33(ICT)5( OF)]TJ /Span<>> BDC 5.312 0 Td ( )Tj EMC [(INTE)25(REST)61.9(:)]TJ /T1_1 1 Tf 0 Tc 0.023 Tw 4.559 0 Td ( the)Tj /Span<>> BDC ( )Tj EMC [(authors declare no conf)-22(lict of)]TJ /Span<>> BDC ( )Tj EMC (interest)Tj /T1_2 1 Tf 0.01 Tc -0.01 Tw -9.871 -1.909 Td [(FUNDIN)23(G:)]TJ /T1_1 1 Tf 0 Tc 0.023 Tw 4.202 0 Td [( this research w)13(as car)-15.9(r)-37(ied out without sponsorship)]TJ /T1_2 1 Tf 0.037 Tc 0.129 Tw -4.202 -2.617 Td [(F)3.2(O)-4.6(R)8.7( C)-17.5(I)-15.5(T)45.4(A)37.5(T)-24.5(I)-1.3(ON:)]TJ /T1_3 1 Tf 0.023 Tc 0.138 Tw 6.574 0 Td [( M)-8.7(a)-14.9(i)-3.2(n)-11.9(o)-10.3(v)-28.9(s)-11.1(k)-24.2(a)-14.9(y)-24.2(a)]TJ /Span<>> BDC ( )Tj EMC [(O)11.4(.)-23.9(A)-23(. P)-18.6(r)-15.8(o)-11.6(b)-18.2(l)-23.7(e)-11.5(m)-11.6(s a)-7.6(n)-14.5(d p)-13.8(r)-15.7(o)-15.9(s)-9.2(p)-24.8(e)-19(c)-41.6(t)-48.8(s o)-12.1(f)]TJ /Span<>> BDC ( )Tj EMC [(u)-21.9(s)-26.1(i)-3.2(n)-11.9(g m)-12.4(o)-11.8(r)-39.1(p)-15.9(h)-10.9(o)-15.6(l)-20.9(o)-18.6(g)-28.9(i)-5(c)-21.5(a)-11.4(l r)-56.4(i)-7.4(s)-11.1(k f)-39.2(a)-11.1(c)-41.5(t)-21.9(o)-11.8(r)-30.3(s f)-25.2(o)-11.8(r l)-8.3(y)-27.5(m)-5.2(p)-15.9(h n)-11.9(o)-20.4(d)-15.3(e m)-16.6(e)-22.2(t)-36.9(a)-26.6(s)-29.2(t)-36.8(a)-26.7(s)-26(i)-7.4(s i)-3.1(n T)25.7(1)23( )]TJ 0.018 Tc -0.035 Tw -6.579 -1.2 Td [(c)-6.4(o)-15.4(l)-20.8(o)-11.7(r)-18.9(e)-19(c)-41.4(t)-36.6(a)-11.3(l c)-21.3(a)-7.5(n)-9.9(c)-9.5(e)-12(r \()39.3(r)-18.9(e)-15.7(v)-51.7(i)-10.8(e)-12.4(w)19.8(\))10.5(. )]TJ /T1_1 1 Tf 0.028 Tc -0.028 Tw [(K)14(ol)3.7(op)2.6(r)3.2(o)3.5(k)-19(t)2.3(ol)3.8(o)-3.2(g)-13.1(i)6.9(a)5.9(.)]TJ /T1_3 1 Tf 0.018 Tc -0.035 Tw 18.583 0 Td [( 2)-8.8(0)-3.7(2)-1.2(5)23.4(;)9.9(2)9(4)-13.4(\()40.2(4)30.4(\))14.7(:)21(1)24.3(7)-4.5(7)35.8(\226)50.9(1)-2.3(8)1.5(7)80.2(. \()-0.8(i)-3(n R)-6.4(u)-21.7(s)-22.2(s)-15.4(.)43.4(\))10.5(. h)-17(t)-49.3(t)-29.2(p)-18.6(s)-7.9(:)2.1(/)84.8(/)36.5(d)-11(o)-12.3(i.)2.8(o)-11.6(r)-16.6(g)-22.7(/)11.4(1)14.1(0)6.6(.)-5.4(3)8(3)-15.8(8)1.5(7)4.7(8/)8.1(2)-8.8(0)9.4(7)-1.8(3)-13.1(-)41.3(7)10.8(5)0.5(5)-8.7(6)-26.6(-)9.8(2)-8.7(0)-3.7(2)-1.3(5)-23.4(-)9.9(2)8.9(4)-28.4(-)-30.1(4)-28.4(-)55.3(1)24.3(7)-4.6(7)36.3(-)55.3(1)-2.3(8)1.4(7)]TJ /T1_2 1 Tf 0.01 Tc 0.206 Tw -18.578 -2.617 Td [(\021\024\027\030\026)5( \024\033\023)5( \t\030\027\030\t\032\026\037\032:)]TJ /T1_1 1 Tf 0 Tc 0.211 Tw 10.953 0 Td ( \214\037\004\020\034\036\024\021\037\030 \240\027\003\013\037 \205\027\016\ \021\024\037\020\b\033\034\036\020\037, \216\223\210\215 \253\217\214\200\ \221 \021\034\027\034\f\033\034\021\035\034\027\034\013\022\022 \022\006\ \016\020\022 \205.\217.)Tj /Span<>> BDC ( )Tj EMC (\213\032\201\022\002\273 \214\022\020\031\b\033\037\036\037 \213\034\024\ \024\022\022, )Tj 0.023 Tw -10.958 -1.2 Td (\023\027.)Tj /Span<>> BDC ( )Tj EMC (\207\037\027\030\006\037 \205\b\022\027\030, \b.)Tj /Span<>> BDC ( )Tj EMC (2, \214\034\024\021\036\037, 123423, \213\034\024\024\022\030; e-mail: m\ oalex_68@mail.ru)Tj /T1_2 1 Tf 0.01 Tc -0.017 Tw 0.005 -1.2 Td [(ADDRESS)4.9( F)13(OR)5( C)19(ORRESPONDEN)23(CE:)]TJ /T1_1 1 Tf 0 Tc -0.012 Tw 13.981 0 Td [( Mainovsk)11(aya O.A., Ryzhikh N)18(ational Medical R)21(esearch Center of)]TJ /Span<>> BDC ( )Tj EMC [(Colop)46.1(roctology)42.1(, Salyama Adilya st., 2, Moscow)52(, )]TJ 0.023 Tw -13.986 -1.2 Td [(123423, R)22(ussia; e-mail: moale)-15(x_68@mail.ru)]TJ 0 Tw 0 -2.792 TD (\n\037\035\037 \f\034\024\035\023\f\027\016\020\022\030)Tj /Span<>> BDC ( )Tj EMC (\227 18.07.2025)Tj /Span<>> BDC ( )Tj EMC 19.488 0 Td (\t\034\024\027\016 \b\034\033\037\025\034\035\021\022)Tj /Span<>> BDC ( )Tj EMC (\227 02.09.2025)Tj /Span<>> BDC ( )Tj EMC 18.78 0 Td (\t\033\022\020\030\035\034 \021)Tj /Span<>> BDC ( )Tj EMC (\f\023\025\027\022\021\037\007\022\022)Tj /Span<>> BDC ( )Tj EMC (\227 10.11.2025)Tj ( )Tj -38.268 -1.375 Td (Received)Tj /Span<>> BDC ( )Tj EMC (\227 18.07.2025)Tj /Span<>> BDC ( )Tj EMC 19.488 0 Td (Revised)Tj /Span<>> BDC ( )Tj EMC (\227 02.09.2025)Tj /Span<>> BDC ( )Tj EMC 18.78 0 Td (Accepted for publication)Tj /Span<>> BDC ( )Tj EMC (\227 10.11.2025)Tj ET 1 0.68 0 0.12 k /GS0 gs q 1 0 0 1 42.5197 589.1533 cm 0 0 m 0 0 l 0 -11.339 l 42.52 -11.339 l 42.52 0 l h f Q BT 0 0 0 0 k /T1_2 1 Tf 9 0 0 9 47.6607 580.226 Tm (\027\030\013\016\n\030)Tj ET 1 0.68 0 0.12 k q 1 0 0 1 42.5197 309.5908 cm 0 0 m 0 0 l 0 -11.339 l 42.52 -11.339 l 42.52 0 l h f Q BT 0 0 0 0 k /T1_2 1 Tf 9 0 0 9 45.2263 300.6635 Tm (ABSTRACT)Tj 1 0.68 0 0.12 k /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\206)10(\002\036\033 \035\030\032\003\033)30(\n)42(\032)-21(\230\033\241)]TJ 57.136 0 Td (REVIEW)Tj /T1_4 1 Tf 25 0 0 25 505.6144 56.0378 Tm 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A)15(d)-16(opt)-32(ion and success )]TJ 0.055 Tw -1.796 -1.25 Td [(r)-33(a)15(tes )0.5(of)]TJ /Span<>> BDC ( )Tj EMC 3.394 0 Td [(per)-37(ineal )0.5(p)25(r)-32(o)-16(cedur)-23.9(es for )0.5(f)-28(istul)-15.9(a-in-ano: )0.5(a)]TJ /Span<>> BDC ( )Tj EMC [(sy)-12.9(stema)15(t)-32(ic )0.5(r)-24(ev)-16(iew. )]TJ /T1_1 1 Tf 0.307 Tw -3.394 -1.25 Td (Colorectal Dis)Tj /T1_0 1 Tf [(. 2016 Ma)15(y;18\(5\):441\22658. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1111/codi.13330)Tj 0 0 0 1 k /GS1 gs ( )Tj 0.023 Tw T* (PMID: 26990602.)Tj 0.051 Tw T* (23.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(R)-10(a)15(t)-30(t)17(o)]TJ /Span<>> BDC ( )Tj EMC 2.485 0 Td [(C, )0.5(L)-32(i)-23.9(t)-30(t)15(a)]TJ /Span<>> BDC ( )Tj EMC 3.18 0 Td [(F, )0.5(P)40(ar)-24(ell)30.1(o)]TJ /Span<>> BDC ( )Tj EMC 3.906 0 Td [(A, )0.5(e)-12(t)]TJ /Span<>> BDC ( )Tj EMC 2.137 0 Td [(al. )0.5(Gor)-23.9(e )0.5(Bio-A\256 )0.6(F)-19(istul)-16(a )0.6(Pl)35(ug: )0.5(a)]TJ /Span<>> BDC ( )Tj EMC 12.518 0 Td (new )Tj 0.057 Tw -26.022 -1.25 Td [(sphinc)-16(ter-sp)32.1(ar)-37(ing p)25(r)-32(o)-16(cedur)-23.9(e for com)10(ple)-18(x anal )0.5(f)-28(istul)-16(a. )]TJ /T1_1 1 Tf [(Colorectal )0.5(Dis.)]TJ /T1_0 1 Tf 0 Tw ( )Tj 0.023 Tw T* [(2012 Ma)15(y;14\(5\):e264\2269. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1111/j.1463-1318.2012.02964.x)Tj 0 0 0 1 k /GS1 gs 0.222 Tw T* (24.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Ommer)Tj /Span<>> BDC ( )Tj EMC [(A, Her)-32(old)]TJ /Span<>> BDC ( )Tj EMC [(A, Jo)-16(os)]TJ /Span<>> BDC ( )Tj EMC [(A, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Gor)-23.9(e BioA F)-19(istul)-16(a Pl)35.1(ug in )]TJ 0.178 Tw -1.796 -1.25 Td [(t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(tr)-23.9(ea)15(tment of)]TJ /Span<>> BDC ( )Tj EMC [(high )0.5(anal f)-28(istul)-15.9(as--ini)-24(t)-32(ial )0.5(r)-24(esul)56(ts )0.5(fr)-32(om a)]TJ /Span<>> BDC ( )Tj EMC [(Ger)-16(man )]TJ 0 Tw T* [(mul)56(t)-32(icenter-stud)17.1(y. )]TJ /T1_1 1 Tf 0.023 Tw 7.753 0 Td (Ger Med Sci.)Tj /T1_0 1 Tf [( 2012;10:Do)-16(c13.)]TJ 0.082 Tw -7.753 -1.25 Td (25.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Cintr)-32(on)]TJ /Span<>> BDC ( )Tj EMC [(JR, A)-14(bcar)-36.9(ian)]TJ /Span<>> BDC ( )Tj EMC [(H, Chaudhr)-24(y)]TJ /Span<>> BDC ( )Tj EMC [(V, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. T)50(r)-24(ea)15(tment of)]TJ /Span<>> BDC ( )Tj EMC [(f)-28(istul)-15.9(a-)]TJ 0.044 Tw -1.796 -1.25 Td (in-ano using a)Tj /Span<>> BDC ( )Tj EMC [(por)-32(c)-23.9(ine s)26(mall intest)-31.9(inal submucosa anal f)-27.9(istul)-16(a pl)34.9(ug. )]TJ /T1_1 1 Tf 0.023 Tw T* [(T)54(ech Colop)46.1(roctol.)]TJ /T1_0 1 Tf ( 2013;17:187\226191.)Tj -0.014 Tw T* (26.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Cest)15(ar)-31.9(o)]TJ /Span<>> BDC ( )Tj EMC [(G, De R)10.9(osa)]TJ /Span<>> BDC ( )Tj EMC [(M., Gent)-32(ile)]TJ /Span<>> BDC ( )Tj EMC [(M. T)50(r)-24(ea)15(tment of)]TJ /Span<>> BDC ( )Tj EMC [(f)-28(istul)-16(a in ano wi)-23.9(t)-13(h )]TJ 0.199 Tw -1.796 -1.25 Td [(f)-28(ibr)-37(in gl)35(ue: p)25(r)-24(el)-31(iminar)-23.9(y r)-24(esul)56.1(ts fr)-31.9(om a)]TJ /Span<>> BDC ( )Tj EMC [(p)25(r)-32(ospec)-16(t)-32(i)-16(ve stud)17(y. )]TJ /T1_1 1 Tf 0 Tw [(Miner)-42(v)16(a )]TJ T* (Chir.)Tj /T1_0 1 Tf 0.023 Tw [( 2014 A)10(ug;69\(4\):225\2268.)]TJ 0.03 Tw T* (27.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Ja)15(yne)]TJ /Span<>> BDC ( )Tj EMC (D, Damian)Tj /Span<>> BDC ( )Tj EMC [(MB, R)-24(ichar)-23.9(d)]TJ /Span<>> BDC ( )Tj EMC [(G, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC (al. A)Tj /Span<>> BDC ( )Tj EMC [(Mul)56(t)-32(icenter R)-10(and)-15.9(omized )]TJ 0.151 Tw -1.796 -1.25 Td [(Contr)-32(olled T)49.9(r)-36.9(ial Com)10(p)32(ar)-37(ing Safe)-11.9(t)-10(y, Ef)-56(f)-28(ica)-17(cy, and Cost-ef)-56(fec)-16(t)-31.9(i)-16(veness )]TJ 0.01 Tc 0.357 Tw T* (of)Tj /Span<>> BDC 0.834 0 Td ( )Tj EMC [(t)-12.6(h)0.5(e S)0.5(ur)-31.5(gis)0.5(is)0.5( Ana)0.5(l F)-18.5(is)0.5(tu)0.5(l)-15.6(a)0.5( P)0.5(l)35.4(u)0.5(g V)30.4(e)0.5(r)-9.6(s)0.5(us)0.5( Sur)-31.5(ge)0.5(on)0.5(\246s P)35.5(r)-23.6(e)0.5(fe)0.5(r)-23.6(e)0.5(nce)10( )]TJ 0.011 Tc 0.421 Tw -0.834 -1.25 Td [(for T)49.6(r)-33.3(anssphinc)-16.3(ter)-37.3(ic F)-19.3(istul)-16.3(a-in-Ano. )]TJ /T1_1 1 Tf (Annals of)Tj /Span<>> BDC ( )Tj EMC [(Surg)11.6(er)-43.4(y.)]TJ /T1_0 1 Tf [( Mar)-32.3(ch)11( )]TJ 0 Tc 0 Tw T* (2021;273\(3\):433\226441.)Tj 0.118 Tw T* (28.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Han)Tj /Span<>> BDC ( )Tj EMC [(JG, Y)-29(i)]TJ /Span<>> BDC ( )Tj EMC 4.607 0 Td [(BQ, W)12.1(ang)]TJ /Span<>> BDC ( )Tj EMC [(ZJ, e)-11.9(t)]TJ /Span<>> BDC ( )Tj EMC [(al. )0.5(L)-32(iga)15(t)-32(ion of)]TJ /Span<>> BDC ( )Tj EMC 13.044 0 Td [(t)-13(he )0.5(inter)-10(sphinc)-16(ter)-36.9(ic )]TJ 0.016 Tw -19.446 -1.25 Td [(f)-28(istul)-15.9(a tr)-33(a)-17(c)-16(t pl)35(us a)]TJ /Span<>> BDC ( )Tj EMC [(biop)25(r)-32(ost)-13(he)-12(t)-31.9(ic anal f)-28(istul)-16(a pl)35(ug \(LIFT-Pl)35.1(ug\): a)]TJ /Span<>> BDC ( )Tj EMC (new )Tj 0.096 Tw T* [(technique for f)-28(istul)-15.9(a-in-ano. )]TJ /T1_1 1 Tf (Colorectal Dis.)Tj /T1_0 1 Tf [( 2013 Ma)15(y;15\(5\):582\2266. )]TJ 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1111/codi.12062)Tj 0 0 0 1 k /GS1 gs 0.15 Tw -1.847 -1.25 Td (29.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(S)15(t)15(amos)]TJ /Span<>> BDC ( )Tj EMC (MJ, Snyder)Tj /Span<>> BDC ( )Tj EMC [(M, R)11(obb)]TJ /Span<>> BDC ( )Tj EMC [(B)11(W, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. P)35(r)-32(ospec)-16(t)-32(i)-16(ve mul)56(t)-32(icenter )]TJ 0.143 Tw -1.796 -1.25 Td [(stud)17(y of)]TJ /Span<>> BDC ( )Tj EMC (a)Tj /Span<>> BDC ( )Tj EMC [(synt)-12.9(he)-12(t)-32(ic bioabsor)-24(bable anal f)-28(istul)-15.9(a pl)35(ug t)17(o)]TJ /Span<>> BDC ( )Tj EMC [(tr)-24(ea)15(t cr)-24(yp)]TJ 0 Tw (-)Tj 0.171 Tw T* [(t)17(o)-16(gl)-16(andul)-15.9(ar tr)-33(anssphinc)-16(ter)-36.9(ic anal f)-28(istul)-16(as. )]TJ /T1_1 1 Tf [(Dis Colon R)21(ectum. )]TJ /T1_0 1 Tf 0 Tw (2015 )Tj -0 -1.25 Td (Mar;58\(3\):344\22651.)Tj 0.137 Tw T* (30.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(K\366ck)10(er)-30(l)-30.9(ing)]TJ /Span<>> BDC ( )Tj EMC [(F, Al)-15.9(am)]TJ /Span<>> BDC ( )Tj EMC [(NN, Nar)-32.9(ang)]TJ /Span<>> BDC ( )Tj EMC [(SK, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. T)50(r)-23.9(ea)15(tment of)]TJ /Span<>> BDC ( )Tj EMC [(F)-19(istul)-15.9(a-)]TJ 0.142 Tw -1.796 -1.25 Td [(In-Ano wi)-23.9(t)-13(h F)-19(istul)-16(a Pl)35(ug)]TJ /Span<>> BDC ( )Tj EMC (\227 a)Tj /Span<>> BDC ( )Tj EMC [(R)13(ev)-16(iew U)13(nder Spec)-24(ial Consider)-32.9(a)15(t)-32(ion )]TJ 0.017 Tw T* (of)Tj /Span<>> BDC ( )Tj EMC [(t)-13(he T)40(echnique. )]TJ /T1_1 1 Tf [(Smar)-39.9(t F)27(ront Surg.)]TJ /T1_0 1 Tf [( 2015 O)-16(c)-16(t 16;2:55. d)-15.9(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.3389/)Tj T* [(fsur)-32(g.2015.00055)]TJ 0 0 0 1 k /GS1 gs 0.023 Tw [( eCollec)-16(t)-32(ion 2015.)]TJ 0.153 Tw T* (31.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Xu)Tj /Span<>> BDC ( )Tj EMC [(Y, T)40(ang)]TJ /Span<>> BDC ( )Tj EMC [(W. Com)10(p)32(ar)-37(ison of)]TJ /Span<>> BDC ( )Tj EMC [(an anal f)-28(istul)-16(a pl)35(ug and mucosa )]TJ 0.099 Tw -1.796 -1.25 Td [(ad)-17(v)-15(ancement fl)-16(ap for com)10(ple)-18(x anal f)-28(istul)-16(as: a)]TJ /Span<>> BDC ( )Tj EMC [(me)-12(t)15(a-anal)35.1(y)-13(sis. )]TJ /T1_1 1 Tf [(A)53(NZ J )]TJ 0 Tw T* (Surg.)Tj /T1_0 1 Tf 0.006 Tw [( 2016 Dec;86\(12\):978\226982. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1111/ans.13751)Tj 0 0 0 1 k /GS1 gs 0.006 Tw ( Epub 2016 )Tj 0.023 Tw T* (Sep 29.)Tj 0.109 Tw T* (32.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(L)-32(in)]TJ /Span<>> BDC ( )Tj EMC (H, Jin)Tj /Span<>> BDC ( )Tj EMC (Z, Zhu)Tj /Span<>> BDC ( )Tj EMC [(Y, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Anal f)-28(istul)-16(ae pl)35(ug vs r)-23.9(ec)-16(t)15(al ad)-17(v)-15(ance)]TJ 0 Tw (-)Tj -0.015 Tw -1.796 -1.25 Td [(ment fl)-16(ap for t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(tr)-23.9(ea)15(tment of)]TJ /Span<>> BDC ( )Tj EMC [(com)10.1(ple)-18(x cr)-24(ypt)17(o)-16(gl)-16(andul)-15.9(ar anal f)-28(istul)-15.9(as: )]TJ 0.229 Tw T* (a)Tj /Span<>> BDC ( )Tj EMC [(sy)-13(stema)15.1(t)-32(ic r)-23.9(ev)-16(iew and me)-12(t)15(a-anal)35(y)-13(sis of)]TJ /Span<>> BDC ( )Tj EMC [(studies wi)-24(t)-13(h l)30(ong-ter)-16(m )]TJ 0 Tw T* [(foll)30(o)-14(w-up. )]TJ /T1_1 1 Tf 0.2 Tw 4.548 0 Td (Colorectal Dis)Tj /T1_0 1 Tf [(. 2019 Ma)15(y;21\(5\):502\226515. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1111/)Tj -4.548 -1.25 Td (codi.14504)Tj 0 0 0 1 k /GS1 gs 0.3 Tw T* (33.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(P)10(ommar)-23.9(e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(E, Benfr)-23.9(ed)17(j)]TJ /Span<>> BDC ( )Tj EMC [(P, S)-16(oud)42(an)]TJ /Span<>> BDC ( )Tj EMC [(D, e)-11.9(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Sphinc)-16(ter-sp)32.1(ar)-37(ing )]TJ 0.126 Tw -1.796 -1.25 Td [(techniques for f)-28(istul)-15.9(as-in-ano. )]TJ /T1_1 1 Tf (J Visc Surg.)Tj /T1_0 1 Tf [( 2015 Ap)25(r;152\(2 Suppl\): )]TJ 0.004 Tc 0.35 Tw T* [(S31\2266. d)-16.4(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs -0.004 Tw [(10.1016/j.jv)-16.4(iscsur)-32.4(g.2014.08.002)]TJ 0 0 0 1 k /GS1 gs 0.35 Tw [( Epub 2014 O)-16.4(c)-16.5(t 3.)4( )]TJ 0 Tc 0.023 Tw T* (PMID: 25280598.)Tj 0.178 Tw T* [(34.Cir)-32(o)-16(cchi)]TJ /Span<>> BDC ( )Tj EMC [(R, Sant)17(or)-31.9(o)]TJ /Span<>> BDC ( )Tj EMC [(A, T)50(r)-33(astull)-30.9(i)]TJ /Span<>> BDC ( )Tj EMC [(S, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Me)-12(t)15(a-anal)35.1(y)-13(sis of)]TJ /Span<>> BDC ( )Tj EMC [(f)-28(ibr)-37(in )]TJ 0.188 Tw T* [(gl)35(ue ver)-9.9(sus sur)-32(ger)-23.9(y for tr)-24(ea)15(tment of)]TJ /Span<>> BDC ( )Tj EMC [(f)-28(istul)-15.9(a-in-ano. )]TJ /T1_1 1 Tf (Ann Ital Chir.)Tj /T1_0 1 Tf 0 Tw ( )Tj T* (2010;81:349\226356.)Tj 0.03 Tw 29.055 80 Td (35.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Al)56(t)17(omar)-23.9(e)]TJ /Span<>> BDC ( )Tj EMC 3.844 0 Td [(DF, )0.5(G)20(r)-24(eco)]TJ /Span<>> BDC ( )Tj EMC 3.952 0 Td [(V)17(J, )0.5(T)50(r)-37(icomi)]TJ /Span<>> BDC ( )Tj EMC 4.623 0 Td [(NN, )0.5(e)-12(t)]TJ /Span<>> BDC ( )Tj EMC 2.719 0 Td [(al. )0.5(Se)-12(t)17(on )0.5(or )0.5(gl)35(ue )0.5(for )0.5(tr)-32.9(ans-)]TJ 0.073 Tw -16.934 -1.25 Td [(sphinc)-16(ter)-36.9(ic anal f)-28(istul)-15.9(ae: a)]TJ /Span<>> BDC ( )Tj EMC [(p)25(r)-32(ospec)-16(t)-32(i)-16(ve r)-33(and)-16(omized cr)-31.9(ossover cl)-30.9(ini)]TJ 0 Tw (-)Tj 0.023 Tw T* [(cal tr)-36.9(ial. )]TJ /T1_1 1 Tf (Colorectal Dis.)Tj /T1_0 1 Tf ( 2011 Jan;13\(1\):82\2266.)Tj 0.295 Tw T* (36.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Mishr)-33(a)]TJ /Span<>> BDC ( )Tj EMC [(A, S)-16(hah)]TJ /Span<>> BDC ( )Tj EMC (S, Nar)Tj /Span<>> BDC ( )Tj EMC [(A)35(S, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. T)47(he)]TJ /Span<>> BDC ( )Tj EMC [(r)-32(ole of)]TJ /Span<>> BDC ( )Tj EMC [(f)-28(ibr)-37(in gl)35(ue in )]TJ 0.221 Tw -1.796 -1.25 Td [(t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(tr)-24(ea)15.1(tment of)]TJ /Span<>> BDC ( )Tj EMC [(high and l)30.1(o)-14(w f)-28(istul)-16(as in ano. )]TJ /T1_1 1 Tf [(J Clin Diagn R)21(es)]TJ /T1_0 1 Tf 0 Tw (. )Tj 0.258 Tw T* [(2013 )0.5(Ma)15(y;7\(5\):876\2269. )0.6(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw 11.821 0 Td (10.7860/JCDR/2013/5387.2964)Tj 0 0 0 1 k /GS1 gs 0.258 Tw [( )0.5(PMID: )]TJ 0.023 Tw -11.821 -1.25 Td (23814732; PMCID: PMC3681059.)Tj 0.02 Tw T* (37.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(P)10(or)-22(t)-32(ill)-15.9(a)]TJ /Span<>> BDC ( )Tj EMC [(F, Mu\361oz-Cr)-21.9(uzad)-16(o)]TJ /Span<>> BDC ( )Tj EMC [(M, Maestr)-24(e)]TJ /Span<>> BDC ( )Tj EMC [(M, e)-11.9(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Pl)-16(a)15(tele)-11.9(t-r)-37(ich pl)-16(as)]TJ 0 Tw (-)Tj 0.142 Tw -1.796 -1.25 Td [(ma \(PRP\) ver)-10(sus f)-28(ibr)-37(in gl)35(ue in cr)-24(ypt)17(o)-16(genic f)-28(istul)-15.9(a-in-ano: a)]TJ /Span<>> BDC ( )Tj EMC (phase )Tj 0.01 Tw T* [(III single-center, r)-33(and)-15.9(omized, d)-16(ouble-bl)-30.9(ind tr)-37(ial. )]TJ /T1_1 1 Tf (Int J Colorectal Dis.)Tj /T1_0 1 Tf 0 Tw ( )Tj 0.023 Tw T* (2019 Jun;34\(6\):1113\2261119.)Tj 0.085 Tw T* (38.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Haim)Tj /Span<>> BDC ( )Tj EMC (N, Neufeld)Tj /Span<>> BDC ( )Tj EMC [(D, Z)-16(i)-15.9(v)]TJ /Span<>> BDC ( )Tj EMC [(Y, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. L)35(ong-ter)-15.9(m r)-23.9(esul)56(ts of)]TJ /Span<>> BDC ( )Tj EMC [(f)-27.9(ibr)-37(in gl)35(ue )]TJ 0.058 Tw -1.796 -1.25 Td [(tr)-24(ea)15.1(tment for cr)-23.9(ypt)17(o)-16(genic per)-37(ianal f)-28(istul)-15.9(as: a)]TJ /Span<>> BDC ( )Tj EMC [(mul)56(t)-32(icenter stud)17(y. )]TJ /T1_1 1 Tf 0 Tw (Dis )Tj 0.023 Tw T* [(Colon R)21.1(ectum.)]TJ /T1_0 1 Tf [( 2011 O)-16(c)-16(t;54\(10\):1279\22683.)]TJ 0.255 Tw T* (39.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (\205\030\024\035\024\r)Tj /Span<>> BDC ( )Tj EMC (\224.\202., \025\031\034\n\017\027\024\r)Tj /Span<>> BDC ( )Tj EMC (\202.\204., \200\t\001\036\020\024\030\024\007\006\036\r)Tj /Span<>> BDC ( )Tj EMC (\212.\200., \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. )Tj 0.013 Tc 0.471 Tw -1.796 -1.25 Td (\210\023\t\021 \007\r\031\b\220\021\026\023\027\024\020\024 \035\036\004\ \036\027\017\016 \f\r\017\013\036\005 \023\030\016\n\024\005 \022\017\001\ \022\017 \f)Tj /Span<>> BDC ( )Tj EMC (\023\030\017)Tj 0 Tc 0 Tw (-)Tj 0.01 Tc 0.376 Tw T* [(\n\036\027\036\027\017\036\n )0.5(\027\017\022\024\021\030\024\n\002\017\027\024\r\024\020\024 \235\017\002\ \030\017\027\024\r\024\020\024 \022\035\036\016 )0.5(\253\025\030\017\024\235\017\021\273.)10( )]TJ /T1_1 1 Tf 0.014 Tc 0.496 Tw T* [(\213)0.5(\034)0.5(\024)0.5(\024)0.5(\022)0.5(\004)0.5(\024)0.5(\021)0.5(\022)0.5(\004)0.5( \201)0.5(\023)0.5(\033)0.5(\020)0.6(\037\027)0.6( \013)0.5(\037)0.5(\024)0.5(\035)0.5(\033)0.5(\034)0.5(\220)0.5(\020)0.5(\035)0.5(\016)0.5(\033)0.5(\034)0.5(\027)0.5(\034)0.5(\013)0.5(\022)0.5(\022)0.5(,)0.5( \013\016)0.6(\f\037)0.6(\035)0.5(\034)0.5(\027)0.5(\034)0.5(\013)0.5(\022)0.5(\022)0.5(,)0.5( \021)0.5(\034)0.5(\027)0.5(\034)]TJ 0 Tc 0 Tw 27.342 0 Td (-)Tj 0.002 Tc -0.002 Tw -27.342 -1.25 Td (\f\033\034\021\035\034\027\034\013\022\022. )Tj /T1_0 1 Tf 0.349 Tw 6.375 0 Td [(2023;33\(6\):44\22652. / F)10.1(r)-31.9(ol)30.1(ov)]TJ /Span<>> BDC ( )Tj EMC [(S.A., K)25.1(uzminov)]TJ /Span<>> BDC ( )Tj EMC [(A.M.,)2( )]TJ 0 Tc 0.346 Tw -6.375 -1.25 Td [(V)-16(y)-13(shegor)-31.9(od)17(tsev)]TJ /Span<>> BDC ( )Tj EMC 6.909 0 Td [(D.V., )0.5(e)-12(t)]TJ /Span<>> BDC ( )Tj EMC 3.821 0 Td [(al. )0.5(T)47(he)]TJ /Span<>> BDC ( )Tj EMC 3.575 0 Td [(e)-18(xper)-36.9(ience )0.5(of)]TJ /Span<>> BDC ( )Tj EMC [(t)-32(w)-13.9(o-st)15(a)-17(ge )0.5(tr)-24(ea)15(t)]TJ 0 Tw (-)Tj 0.093 Tw -14.305 -1.25 Td (ment of)Tj /Span<>> BDC ( )Tj EMC [(r)-24(ec)-16(t)15(al f)-28(istul)-16(as using l)30(o)-14(w-t)-12.9(hr)-32(ombin f)-28(ibr)-36.9(in gl)35(ue \237Cr)-23.9(yophy)-16(te\241. )]TJ /T1_1 1 Tf 0.088 Tw T* [(R)22(ussian Jour)-14(nal of)]TJ /Span<>> BDC ( )Tj EMC [(Gastroenterology, Hepatology, and Colop)46(roctology.)]TJ /T1_0 1 Tf 0 Tw ( )Tj 0.023 Tw T* (2023;33\(6\):44\22652. \(in Russ.\).)Tj 0.2 Tw T* (40.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (An)Tj /Span<>> BDC ( )Tj EMC (Y, Chen)Tj /Span<>> BDC ( )Tj EMC [(X, T)35(ian)]TJ /Span<>> BDC ( )Tj EMC [(M, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Com)10(p)32(ar)-37(ison of)]TJ /Span<>> BDC ( )Tj EMC [(cl)-30.9(inical outcomes )]TJ 0.101 Tw -1.796 -1.25 Td (of)Tj /Span<>> BDC ( )Tj EMC [(anal f)-27.9(istul)-16(a pl)35(ug and end)-16(oanal ad)-17(v)-15(ancement fl)-15.9(ap r)-24(ep)32(air tr)-23.9(ea)15(t)-32(ing )]TJ 0.215 Tw T* [(t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(com)10(ple)-17.9(x anal f)-28(istul)-16(a: a)]TJ /Span<>> BDC ( )Tj EMC [(sy)-12.9(stema)15(t)-32(ic r)-24(ev)-15.9(iew and me)-12(t)15(a-anal)35(y)-13(sis. )]TJ /T1_1 1 Tf 0.023 Tw T* [(U)21(pd)26(ates Surg.)]TJ /T1_0 1 Tf ( 2023 Dec;75\(8\):2103\2262115.)Tj 0.172 Tw T* (41.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Chung)Tj /Span<>> BDC ( )Tj EMC [(W, K)-16(a)-24(zemi)]TJ /Span<>> BDC ( )Tj EMC [(P, K)25(o)]TJ /Span<>> BDC ( )Tj EMC [(D, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Anal f)-28(istul)-15.9(ae pl)35.1(ug and f)-28(ibr)-37(in )]TJ 0.008 Tc 0.349 Tw -1.796 -1.25 Td [(g)0.5(l)35.5(u)0.5(e)0.5( v)0.5(e)0.6(r)-9.5(s)0.5(u)0.5(s)0.5( c)0.5(o)0.5(n)0.5(v)0.5(e)0.5(n)0.5(t)-31.5(i)0.5(o)0.5(n)0.5(a)0.5(l)0.5( t)0.5(r)-23.5(e)0.5(a)15.5(t)0.5(m)0.5(e)0.5(n)0.5(t)0.5( i)0.6(n)0.5( r)-23.5(e)0.5(p)32.5(a)0.5(i)0.5(r)0.5( o)0.5(f)]TJ /Span<>> BDC 21.341 0 Td ( )Tj EMC [(c)0.5(o)0.5(m)10.5(p)0.5(l)0.5(e)-17.5(x)0.6( a)0.5(n)0.5(a)0.5(l)8( )]TJ 0 Tc 0 Tw -21.341 -1.25 Td [(f)-28(istul)-15.9(as. )]TJ /T1_1 1 Tf 0.212 Tw 3.748 0 Td [(Am J )0.5(Surg)]TJ /T1_0 1 Tf [(. 2009 Ma)15.1(y;197\(5\):604\2268. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw 17.76 0 Td (10.1016/j.amj)Tj (-)Tj -21.509 -1.25 Td [(sur)-32(g.2008.12.013)]TJ 0 0 0 1 k /GS1 gs 0.335 Tw T* (42.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Ber)-32(gel)]TJ /Span<>> BDC ( )Tj EMC 3.154 0 Td [(S. Uber W)-15.9(ir)-24(kungen des )0.5(F)-19(ibr)-37(ins. )]TJ /T1_1 1 Tf 14.196 0 Td [(Deutsch )0.5(W)29(ochenschr.)]TJ /T1_0 1 Tf 0 Tw ( )Tj -19.145 -1.25 Td (1909;35:633\226665.)Tj 0.004 Tc 0.349 Tw T* (43.)Tj /Span<>> BDC ( )Tj EMC 1.812 0 Td [(T)35.1(idr)-36.9(ick)]TJ /Span<>> BDC ( )Tj EMC [(R)-12(T, W)12.1(ar)-14.9(ner)]TJ /Span<>> BDC ( )Tj EMC [(ED. F)-18.9(ibr)-36.9(in f)-28(ix)-10.9(a)15.1(t)-31.9(ion of)]TJ /Span<>> BDC ( )Tj EMC [(sk)-15.9(in tr)-32.9(anspl)-16(ants.)4( )]TJ /T1_1 1 Tf 0 Tc 0 Tw -1.812 -1.25 Td [(Surg)12(er)-43(y)]TJ /T1_0 1 Tf 0.023 Tw (. 1944;15:90.)Tj 0.35 Tw T* (44.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Har)-32.1(ve)-11(y)]TJ /Span<>> BDC ( )Tj EMC 3.371 0 Td [(SC. )0.5(F)-19(ibr)-37.1(in )0.5(p)32(aper )0.5(as )0.5(a)]TJ /Span<>> BDC ( )Tj EMC 10.045 0 Td [(hemost)14.9(a)15(t)-32(ic )0.5(a)-17(gent. )]TJ /T1_1 1 Tf 8.26 0 Td [(Ann )0.5(Surg)]TJ /T1_0 1 Tf 0 Tw (. )Tj -23.472 -1.25 Td (1918;68:66\22670.)Tj 0.048 Tw T* (45.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (\205\030\024\035\024\r)Tj /Span<>> BDC ( )Tj EMC (\224.\202., \230\017\021\024\r)Tj /Span<>> BDC ( )Tj EMC (\202.\222., \215\024\035\036\021\024\r)Tj /Span<>> BDC ( )Tj EMC (\203.\203., \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. \236\f\021\024\030\017\004\036\f\022\017\036 )Tj 0.147 Tw -1.796 -1.25 Td (\026\f\023\036\022\021\t \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\r\030\036\n\036\027\027\024\036 \b\017\030\031\030\020\017\004\036\ \f\022\024\036 \035\036\004\036\027\017\036 \002\024\035\034\027\t\b \f)Tj /Span<>> BDC ( )Tj EMC (\027\036\007\024)Tj 0 Tw (-)Tj 0.214 Tw T* [(\f\021\026\021\024\004\027\024\f\021\034\033 )0.7(\026\027\026\035\034\027\024\020\024 )0.6(\f\235\017\027\022\021\036\030\026. )]TJ /T1_1 1 Tf 15.846 0 Td [(\213\034\024\024\022\004\024\021\022\004 )0.6(\201\023\033\020\037\027 )0.6(\013\037\024\035\033\034)]TJ 0 Tw (-)Tj 0.127 Tw -15.846 -1.25 Td (\220\020\035\016\033\034\027\034\013\022\022, \013\016\f\037\035\034\027\ \034\013\022\022, \021\034\027\034\f\033\034\021\035\034\027\034\013\022\ \022)Tj /T1_0 1 Tf (. 2015;25\(3\):78\22684. )Tj 0.259 Tw T* [(/ F)10(r)-32(ol)30(ov)]TJ /Span<>> BDC ( )Tj EMC [(S.A., T)35(i)-24(t)17.1(ov)]TJ /Span<>> BDC ( )Tj EMC [(A.Y)35.1(u., P)10(ole)-12(t)17(ov)]TJ /Span<>> BDC ( )Tj EMC [(N.N., e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Hist)17.1(or)-37(ical aspec)-16(ts )]TJ 0.326 Tw T* [(and moder)-15(n sur)-32(gical tr)-23.9(ea)15(tment of)]TJ /Span<>> BDC ( )Tj EMC [(p)32(a)15(t)-32(ients wi)-24(t)-13(h anal sphinc)-16(ter )]TJ 0 Tw T* [(insuf)-56(f)-27.9(ic)-24(iency. )]TJ /T1_1 1 Tf 0.158 Tw 5.992 0 Td [(R)22(ussian )0.5(Jour)-14(nal )0.5(of)]TJ /Span<>> BDC ( )Tj EMC 7.92 0 Td [(Gastroenterology, )0.6(Hepatology, )0.5(and )]TJ 0 Tw -13.912 -1.25 Td [(Colop)46(roctology. )]TJ /T1_0 1 Tf 0.023 Tw 6.275 0 Td (2015;25\(3\):78\22684. \(in Russ.\).)Tj 0.012 Tc 0.458 Tw -6.275 -1.25 Td (46.)Tj /Span<>> BDC ( )Tj EMC 1.846 0 Td (\025\024\f\021\026\030\036\r)Tj /Span<>> BDC ( )Tj EMC (\236.\200., \221\036\035\t\020\017\027)Tj /Span<>> BDC ( )Tj EMC (\222.\202., \025\024\030\024\035\017\022)Tj /Span<>> BDC ( )Tj EMC (\200.\222., \017)Tj /Span<>> BDC ( )Tj EMC [(\f\024\026\r\021.)12( )]TJ 0.01 Tc 0.377 Tw -1.846 -1.25 Td (\025\035\017\027\017\004\036\f\022\017\036 \030\036\031\035\034\021\026\ \021\t \024\007\027\024\006\036\027\021\030\024\r\024\020\024 \023\030\024\ \f\023\036\022\021\017\r\027\024\020\024 \017\f)Tj 0 Tc 0 Tw (-)Tj 0.288 Tw T* (\f\035\036\007\024\r\026\027\017\016 \023\024)Tj /Span<>> BDC ( )Tj EMC (\024\006\036\027\022\036 \220\235\235\036\022\021\017\r\027\024\f\021\017\ \b\017\030\031\030\020\017\004\036\f\022\024\020\024 \035\036\004\036\027\ \017\016 )Tj -0.026 Tw T* (\021\030\026\027\f- \017)Tj /Span<>> BDC ( )Tj EMC (\220\022\f\021\030\026\f\235\017\027\022\021\036\030\027\t\b \f\r\017\013\ \036\005 \023\030\016\n\024\005 \022\017\001\022\017 \f)Tj /Span<>> BDC ( )Tj EMC (\023\030\017\n\036\027\036\027\017\036\n )Tj 0.35 Tw T* (\002\017\024\023\035\026\f\021\017\004\036\f\022\024\020\024 \022\024\035\ \035\026\020\036\027\024\r\024\020\024 \n\026\021\036\030\017\026\035\026\ . )Tj /T1_1 1 Tf (\205\020\020\037\027\032 \002\022\033\023\033\013\022\022. )Tj /T1_0 1 Tf 0.118 Tw T* [(2018;23\(2\):99\226107. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.18821/1560-9502-2018-23-2-99-107)Tj 0 0 0 1 k /GS1 gs 0.118 Tw ( / )Tj 0.237 Tw -0 -1.25 Td [(K)25(ost)15(ar)-24(ev)]TJ /Span<>> BDC ( )Tj EMC [(I.V., S)-16(hel)35(ygin Y)35(u.A., K)25(or)-32(ol)-31(ik)]TJ /Span<>> BDC ( )Tj EMC [(V.Y)35(u., e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Cl)-31(inical r)-23.9(esul)56(ts )]TJ 0.007 Tc 0.349 Tw T* (of)Tj /Span<>> BDC ( )Tj EMC (a)Tj /Span<>> BDC ( )Tj EMC [(single-center p)25.1(r)-31.9(ospec)-15.9(t)-31.9(i)-15.9(ve stud)17.1(y ev)-14.9(al)35.1(ua)15.1(t)-31.9(ing t)-12.9(he)]TJ /Span<>> BDC ( )Tj EMC [(ef)-55.9(fec)-15.9(t)-31.9(i)-15.9(ve)]TJ 0 Tc 0 Tw (-)Tj 0.34 Tw T* (ness of)Tj /Span<>> BDC ( )Tj EMC [(sur)-31.9(gical tr)-24(ea)15(tment of)]TJ /Span<>> BDC ( )Tj EMC [(tr)-32.9(ans and e)-18(xtr)-33(asphinc)-15.9(ter f)-28(istul)-15.9(as )]TJ 0.07 Tw T* (of)Tj /Span<>> BDC ( )Tj EMC [(t)-13(he r)-24(ec)-16(tum using biopl)-16(ast)-31.9(ic coll)-15.9(a)-17(gen ma)15(ter)-37(ial. )]TJ /T1_1 1 Tf (Annals of)Tj /Span<>> BDC ( )Tj EMC [(surg)12(er)-43(y)]TJ /T1_0 1 Tf 0 Tw (. )Tj 0.023 Tw 0 -1.25 Td (2018;23\(2\):99\226107. \(in Russ.\).)Tj 0.162 Tw T* (47.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (\216\030\033\022\017\027)Tj /Span<>> BDC ( )Tj EMC (\217.\222., \207\030\026\020\017\027\026)Tj /Span<>> BDC ( )Tj EMC (\202.\224., \202\027\024\f\024\r)Tj /Span<>> BDC ( )Tj EMC (\236.\224., \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. \224\021\r\024\035\024\r\t\036 )Tj 0.306 Tw -1.796 -1.25 Td [(\022\035\036\021\022\017, )0.5(\023\024\035\031\004\036\027\027\t\036 \017)]TJ /Span<>> BDC ( )Tj EMC 10.471 0 Td [(\026\031\021\024\035\024\020\017\004\027\024\005 \032\017\030\024\r\024\005\ \021\022\026\027\017, )0.5(\022\026\022 \f\023\024)]TJ 0 Tw (-)Tj 0.002 Tc 0.35 Tw -10.471 -1.25 Td (\f\024\002 \035\036\004\036\027\017\016 \f\035\024\032\027\t\b \f\r\017\013\ \036\005 \026\007\027\036\020\024 \023\030\024\b\024\007\026 \(\f\017\f\ \021\036\n\026\021\017\004\036)Tj 0 Tc 0 Tw (-)Tj 0.284 Tw T* (\f\022\017\005 \024\002\024\030 \035\017\021\036\030\026\021\031\030\t \ \017)Tj /Span<>> BDC ( )Tj EMC (\n\036\021\026\026\027\026\035\017\). )Tj /T1_1 1 Tf (\t\027\037\024\035\022\005\016\024\021\037\030 \002\022\033\023\033\013\022\ \030 )Tj 0.289 Tw T* (\022)Tj /Span<>> BDC ( )Tj EMC 1.021 0 Td [(\220\024\035\016\035\022\005\016\024\021\037\030 )0.6(\006\016\b\022\007\022\020\037. )]TJ /T1_0 1 Tf 11.247 0 Td (2025;\(2\):117)Tj /Span<>> BDC (-)Tj EMC [(127. )0.5(/ )0.5(Khr)-24(yuk)-15.9(in)]TJ /Span<>> BDC ( )Tj EMC 13.102 0 Td [(R.Y)35(u., )]TJ 0.084 Tw -25.37 -1.25 Td [(Br)-33(a)-17(gina)]TJ /Span<>> BDC ( )Tj EMC 3.451 0 Td [(A.S., )0.5(Anosov)]TJ /Span<>> BDC ( )Tj EMC 5.333 0 Td [(I.S., )0.5(e)-12(t)]TJ /Span<>> BDC ( )Tj EMC 3.078 0 Td [(al. )0.5(S)15(tem )0.5(cells )0.5(der)-37(i)-15.9(ved )0.5(fr)-32(om )0.5(aut)17(ol)30(o)-16(gous )]TJ 0.09 Tw -11.862 -1.25 Td [(adipose t)-32(issue as a)]TJ /Span<>> BDC ( )Tj EMC [(tr)-23.9(ea)15(tment for com)10(ple)-18(x anal f)-28(istul)-15.9(as \(sy)-13(stema)15(t)-31.9(ic )]TJ 0.185 Tw T* [(l)-31(i)-24(ter)-32.9(a)15(tur)-24(e r)-24(ev)-16(iew and me)-12(t)15(a-anal)35(y)-13(sis\). )]TJ /T1_1 1 Tf [(Plastic surg)12.1(er)-43(y and aesthetic )]TJ 0 Tw T* (medicine. )Tj /T1_0 1 Tf 0.023 Tw 4.058 0 Td (2025;\(2\):117\226127. \(in 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[(\217)5.5(\036)-19(\007)-20.1(\026\022)-32.6(\021)-17.7(\017)1.5(\030)-11.8(\024)-4.4(\r)-8.8(\026\027)1.8(\017)-8.7(\036)6.5(:)]TJ /T1_3 1 Tf 0.239 Tw [( \210)1.2(\034)5.9(\013)3.7(\034)4.9(\033)2.3(\006)10.3(\022)3.3(\024\035)5.9(\033\034)9.7(\036)]TJ /Span<>> BDC ( )Tj EMC [(\200)28.8(.)43.7(\207)-2.1(.)7.8(, \r)15.6(\034)4.9(\033\034)10.1(\027)9.7(\022)7.7(\021)]TJ /Span<>> BDC ( )Tj EMC [()24.3(.)27.5(\234)26.6(.)7.9(, )]TJ 0 Tw T* [()9.9(\032)9.6(\001)3.3(\016)0.6(\013)3.7(\034)4.9(\033\034\b)5.4(\007)2.7(\016)6.6(\036)]TJ /Span<>> BDC ( )Tj EMC [(\n)1.4(.)28.5()24.3(.)]TJ /T1_2 1 Tf 0.023 Tw 23.244 38.97 Td (AUTHORS CONTRIBUTION)Tj /T1_1 1 Tf 1.756 Tw T* [(C)-6.5(o)0.8(nce)-0.7(p)-12.3(t a)2.4(n)-4.6(d d)-5.5(e)-13.3(s)-16.5(i)3.1(g)1.2(n o)-2.2(f)]TJ /Span<>> BDC ( )Tj EMC [(t)-16.7(h)-5.3(e s)-20(t)-12.8(ud)-10.9(y)-11.8(:)]TJ /T1_3 1 Tf 0 Tw ( )Tj 0.772 Tw T* [(D)-2(m)5.8(i)0.9(t)-5.4(r)-35.3(iy)]TJ /Span<>> BDC ( )Tj EMC [(V)53.1(.)]TJ /Span<>> BDC ( )Tj EMC [(V)-9(y)-1(s)9.6(h)1.9(e)-3.5(g)-2.5(o)1.3(r)2.4(o)-7.8(d)-1.5(c)7.3(e)-4(v)33.6(, I)3.3(l)11(y)3.8(a)]TJ /Span<>> BDC ( )Tj EMC [(S)2.1(.)]TJ /Span<>> BDC ( )Tj EMC [(B)0.8(o)-4.4(g)-2.5(o)1.3(r)-14.6(m)5.8(i)11(s)-10.7(t)-5.3(r)2.4(o)-0.6(v)33.6(, )]TJ -0.002 Tc 0.002 Tw T* [(V)-11(y)1.8(a)-7(che)-20(s)7.3(l)1.3(a)-6.4(v)]TJ /Span<>> BDC 4.255 0 Td ( )Tj EMC [(Y)31.7(u)5.7(.)-2( K)11.2(o)-0.6(ro)-3.1(l)2.3(i)5.9(k)]TJ /T1_1 1 Tf 0 Tc 1.311 Tw -4.255 -1.218 Td [(C)-6.5(o)-5.8(l)-19(l)-14.3(e)-9.4(c)-32.5(t)-37.3(i)3.2(o)0.8(n a)2.5(n)-4.6(d )0.5(p)-3.8(r)-6(o)-7(ce)-13.3(s)-12.8(s)-16.6(i)7.1(n)-1.9(g )0.5(o)-2.2(f)-58.2(t)-16.7(h)-5.3(e )0.5(m)1.8(a)-8.4(t)-15.2(e)-2.1(r)-48(i)5.2(a)-1.5(l)-22.5(:)]TJ /T1_3 1 Tf 0 Tw ( )Tj T* [(K)10.9(i)9.4(r)-35.3(i)7.4(ll)]TJ /Span<>> BDC ( )Tj EMC [(A)-12.6(.)]TJ /Span<>> BDC ( )Tj EMC [(L)-4.6(a)-4.5(z)12.9(ar)2.5(e)-4(v)33.6(, I)3.2(l)11(y)3.8(a)]TJ /Span<>> BDC ( )Tj EMC [(S)2.1(.)]TJ /Span<>> BDC ( )Tj EMC [(B)0.9(o)-4.4(g)-2.5(o)1.3(r)-14.6(m)5.8(i)11(s)-10.7(t)-5.4(r)2.5(o)-0.6(v)]TJ /T1_1 1 Tf 0 -1.218 TD [(W)3.1(r)-48(i)-6(t)-37.4(i)7.1(n)-1.9(g o)-2.2(f)]TJ /Span<>> BDC ( )Tj EMC [(t)-16.7(h)-5.3(e t)-15.2(e)-23.9(x)-36(t)-20(:)]TJ /T1_3 1 Tf [( K)10.9(i)9.4(r)-35.3(i)7.4(ll)]TJ /Span<>> BDC ( )Tj EMC [(A)-12.5(.)]TJ /Span<>> BDC ( )Tj EMC [(L)-4.6(a)-4.5(z)12.9(ar)2.4(e)-4(v)]TJ /T1_1 1 Tf 0.006 Tc -0.006 Tw 0 -1.218 TD [(E)11.6(dit)-31.4(i)13.1(n)4.1(g)15(:)]TJ /T1_3 1 Tf 0 Tc 0.065 Tw 3.238 0 Td [( D)-2(m)5.8(i)0.9(t)-5.4(r)-35.2(iy)]TJ /Span<>> BDC ( )Tj EMC [(V)53.1(.)]TJ /Span<>> BDC ( )Tj EMC [(V)-9(y)-1(s)9.6(h)1.9(e)-3.4(g)-2.5(o)1.3(r)2.4(o)-7.8(d)-1.5(c)7.2(e)-4(v)33.6(, I)3.3(l)11(y)3.8(a)]TJ /Span<>> BDC ( )Tj EMC [(S)2.1(.)]TJ /Span<>> BDC ( )Tj EMC [(B)0.8(o)-4.4(g)-2.5(o)1.3(r)-14.5(m)5.8(i)11(s)-10.7(t)-5.4(r)2.4(o)-0.6(v)33.6(, )]TJ -0.002 Tc 0.002 Tw -3.238 -1.218 Td [(V)-11(y)1.8(a)-7(che)-20(s)7.3(l)1.3(a)-6.4(v)]TJ /Span<>> BDC 4.255 0 Td ( )Tj EMC [(Y)31.7(u)5.7(.)-2( K)11.2(o)-0.6(ro)-3.1(l)2.3(i)5.9(k)]TJ /T1_2 1 Tf 0 Tc 0.023 Tw -4.255 -2.436 Td (\255\026\036\031\036\025\034\226 \017\223 \032\026\020\017\022\032\225 \(\ ORCID\))Tj /T1_1 1 Tf 0.104 Tw T* (\200\t\001\036\020\024\030\024\007\006\036\r \212\n\017\021\030\017\005 \ \200\016\004\036\f\035\026\r\024\r\017\004)Tj /Span<>> BDC ( )Tj EMC (\227 \007.\n.\027., \r\036)Tj 0 Tw (-)Tj 0.054 Tw 0 -1.218 TD [(\007\031\013\017\005 )0.5(\027\026\031\004\027\t\005 )0.6(\f\024\021\030\031\007\027\017\022 )0.6(\205\206\207\211 )0.5(\253\203\204\236\037 )0.5(\022\024\035\024\023\030\024\022\021\024)]TJ 0 Tw (-)Tj 0.088 Tw 0 -1.218 TD (\035\024\020\017\017 \017\n\036\027\017 \202.\203. \217\t\032\017\b\273 \ \204\017\027\007\030\026\r\026 \217\024\f\f\017\017; ORCID )Tj 0 Tw 0 -1.218 TD (0000-0001-6679-1843)Tj 0.214 Tw T* (\025\024\030\024\035\017\022 \200\016\004\036\f\035\026\r \222\030\034\036\ \r\017\004)Tj /Span<>> BDC ( )Tj EMC (\227 \022.\n.\027., \027\026\031\004\027\t\005 \f\024)Tj 0 Tw (-)Tj 0.37 Tw T* (\021\030\031\007\027\017\022 \024\021\007\036\035\026 \024\002\013\036\005\ \023\030\024\022\021\024\035\024\020\017\017 \205\206\207\211 \253\203\204\ \236\037 )Tj 0.482 Tw T* (\022\024\035\024\023\030\024\022\021\024\035\024\020\017\017 \017\n\036\027\ \017 \202.\203. \217\t\032\017\b\273 \204\017\027\007\030\026\r\026 )Tj 0 Tw T* (\217\024\f\f\017\017; ORCID 0000-0003-2619-5929)Tj 0.609 Tw T* (\207\024\020\024\030\n\017\f\021\030\024\r \236\035\034\016 \224\036\030\ \020\036\036\r\017\004)Tj /Span<>> BDC ( )Tj EMC (\227 \022.\n.\027., \r\030\026\004-)Tj 1.005 Tw T* (\022\024\035\024\023\030\024\022\021\024\035\024\020 \205\206\207\211 \253\ \203\204\236\037 \022\024\035\024\023\030\024\022\021\024\035\024\020\017\ \017 )Tj 0.629 Tw T* (\017\n\036\027\017 \202.\203. \217\t\032\017\b\273 \204\017\027\007\030\ \026\r\026 \217\024\f\f\017\017; ORCID )Tj 0 Tw T* (0000-0002-9970-052X)Tj 0.144 Tw T* (\214\026\026\030\036\r \025\017\030\017\035\035 \202\035\036\022\f\036\036\ \r\017\004)Tj /Span<>> BDC ( )Tj EMC (\227 \r\030\026\004-\022\024\035\024\023\030\024\022\021\024\035\024\020\ )Tj 0.221 Tw T* (\205\206\207\211 \253\203\204\236\037 \022\024\035\024\023\030\024\022\021\ \024\035\024\020\017\017 \017\n\036\027\017 \202.\203. \217\t\032\017\b\273\ )Tj 0 Tw T* (\204\017\027\007\030\026\r\026 \217\024\f\f\017\017; ORCID 0009-0000-39\ 35-674X)Tj /T1_2 1 Tf 0.023 Tw 0 -2.436 TD (INFORMATION ABOUT THE)Tj /Span<>> BDC ( )Tj EMC (AUTHORS \(ORCID\))Tj /T1_1 1 Tf 0 Tw 0 -1.218 TD [(Dmi)-24(tr)-23.9(y V. V)-16(y)-13(shegor)-31.9(od)17(tsev)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0001-6679-1843)Tj T* [(V)-16(y)22(a)-17(chesl)-15.9(av Y)35(u. K)25(or)-32(ol)-31(ik)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0003-2619-5929)Tj T* [(Il)35(y)22(a S. Bo)-15.9(gor)-16(mistr)-32(ov)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0002-9970-052X)Tj T* [(Kir)-37(ill A. L)-31.9(a)-23.9(zar)-24(ev)]TJ /Span<>> BDC ( )Tj EMC (\227 0009-0000-3935-674X)Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 42.5896 298.5999 Tm [(\r\031\024\034\033)48(\026)45(\024)-10(\223\033)48(\026/REFERENCES)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0 Tc 0.287 Tw 8 0 0 8 42.5197 285.7652 Tm (1.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Gor)-24(d)-16(on)]TJ /Span<>> BDC ( )Tj EMC [(PH, Ni)-16(v)-15(a)15(t)-24(vongs)]TJ /Span<>> BDC ( )Tj EMC [(S. P)35(r)-37(inc)-24(iples and P)35(r)-33(a)-17(c)-16(t)-32(ice of)]TJ /Span<>> BDC ( )Tj EMC [(Sur)-31.9(ger)-24(y )]TJ 0.169 Tw -1.296 -1.25 Td [(for )0.5(t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(Col)30(on, )0.5(R)13(ec)-16(tum, )0.5(and Anus. )0.5(Second Edi)-24(t)-32(ion. )0.5(Q)-16(ual)-31(i)-23.9(t)-10(y Medical )]TJ 0.023 Tw 0 -1.25 TD [(P)20(ubl)-31(ishing, Inc. S)15(t. L)35(ouis, Missour)-37(i. 1999;10:242\226286.)]TJ -0.022 Tw T* (2.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (\221\036\035\t\020\017\027)Tj /Span<>> BDC ( )Tj EMC (\222.\202., \207\035\026\020\024\007\026\030\027\t\005)Tj /Span<>> BDC ( )Tj EMC (\214.\202. \224\023\030\026\r\024\004\027\017\022 \023\024)Tj /Span<>> BDC ( )Tj EMC (\022\024\035\024\023\030\024\022\021\024\035\024)Tj 0 Tw (-)Tj 0.038 Tw -1.296 -1.25 Td [(\020\017\017. \206\036\024\021\026\030-\204\036\007\017\026, 2014. /S)-16(hel)35.1(ygin)]TJ /Span<>> BDC ( )Tj EMC [(Y.A., Bl)-16(a)-17(god)42(ar)-15(ny)]TJ /Span<>> BDC ( )Tj EMC [(L.A. Handbo)-16(ok )]TJ 0.023 Tw T* (of)Tj /Span<>> BDC ( )Tj EMC [(col)30(op)25(r)-32(o)-16(c)-15.9(t)17(ol)30(o)-16(g)16(y. Geo)17(t)15(ar-Media, 2014. \(in Russ.\).)]TJ 0.207 Tw T* (3.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Cos)26(man)]TJ /Span<>> BDC ( )Tj EMC [(BC. All\246s )0.5(W)21.9(ell T)47(ha)15(t Ends W)22(ell: S)-16(hak)10(espear)-23.9(e\246s tr)-23.9(ea)15(tment )]TJ 0.023 Tw -1.296 -1.25 Td (of)Tj /Span<>> BDC ( )Tj EMC [(anal f)-27.9(istul)-16(a. )]TJ /T1_3 1 Tf [(Dis Colon R)21(ectum.)]TJ /T1_1 1 Tf ( 1998 Jul;41\(7\):914\22624.)Tj 0.017 Tw T* (4.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(P)40(ar)-24(k)-10(s)]TJ /Span<>> BDC ( )Tj EMC [(A)16(G, Gor)-24(d)-16(on)]TJ /Span<>> BDC ( )Tj EMC [(PH, Har)-24(dcastle)]TJ /Span<>> BDC ( )Tj EMC (JD. A)Tj /Span<>> BDC ( )Tj EMC [(cl)-16(assif)-28(ica)15(t)-32(ion of)]TJ /Span<>> BDC ( )Tj EMC [(f)-28(istul)-16(a-in-)]TJ 0 Tw -1.296 -1.25 Td (ano. )Tj /T1_3 1 Tf 0.023 Tw 2.034 0 Td (Br J Surg.)Tj /T1_1 1 Tf ( 1976;63\(1\):1\22612.)Tj 0.249 Tw -2.034 -1.25 Td (5.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (Hammond)Tj /Span<>> BDC ( )Tj EMC [(TM, G)20(r)-33(ahn)]TJ /Span<>> BDC ( )Tj EMC [(MF, L)35(unniss)]TJ /Span<>> BDC ( )Tj EMC [(P)35.1(J. F)-19(ibr)-37(in gl)35(ue in t)-13(he)]TJ /Span<>> BDC ( )Tj EMC (man)Tj 0 Tw (-)Tj 0.305 Tw -1.296 -1.25 Td [(a)-17(gement of)]TJ /Span<>> BDC ( )Tj EMC 5.396 0 Td [(anal f)-28(istul)-15.9(ae. )]TJ /T1_3 1 Tf [(Colorectal )0.5(Dis.)]TJ /T1_1 1 Tf [( )0.5(2004 Sep;6\(5\):308\22619. )]TJ 0 Tw -5.396 -1.25 Td [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1111/j.1463-1318.2004.00676.x)Tj 0 0 0 1 k /GS1 gs 0.023 Tw ( PMID: 15335361.)Tj -0.009 Tw -1.847 -1.25 Td (6.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Hjor)-22(tr)-21.9(up)]TJ /Span<>> BDC ( )Tj EMC [(A, M)-23.9(oesgaar)-24(d)]TJ /Span<>> BDC ( )Tj EMC [(F, Kjaer)-31.9(g\345r)-24(d)]TJ /Span<>> BDC ( )Tj EMC [(J. F)-19(ibr)-37(in adhesi)-16(ve in t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(tr)-24(ea)15(t)]TJ 0 Tw (-)Tj 0.081 Tw -1.296 -1.25 Td (ment of)Tj /Span<>> BDC ( )Tj EMC [(per)-36.9(ineal f)-28(istul)-15.9(as. )]TJ /T1_3 1 Tf [(Dis Colon R)21(ectum)]TJ /T1_1 1 Tf (. 1991 Sep;34\(9\):752\2264. )Tj 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1007/BF02051064)Tj 0 0 0 1 k /GS1 gs 0.023 Tw ( PMID: 1914738.)Tj 0.032 Tw -1.847 -1.25 Td (7.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Ja)-17(cob)]TJ /Span<>> BDC ( )Tj EMC 2.632 0 Td [(T)25(J, )0.6(P)30(er)-33(ak)-17(a)15(t)-13(h)]TJ /Span<>> BDC ( )Tj EMC 5.156 0 Td [(B, )0.6(K)25(eighle)-11(y)]TJ /Span<>> BDC ( )Tj EMC 4.7 0 Td [(MR. )0.6(Sur)-32(gical )0.6(inter)-32(vent)-32(ion )0.6(for )0.5(ano)]TJ 0 Tw (-)Tj -0.073 Tw -13.784 -1.25 Td [(r)-24(ec)-16(t)15.1(al f)-28(istul)-15.9(a. )]TJ /T1_3 1 Tf [(Cochrane Database Syst R)20.9(ev)]TJ /T1_1 1 Tf [(. 2010 Ma)15(y 12;\(5\):CD006319. )]TJ 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1002/14651858.CD006319.pub2)Tj 0 0 0 1 k /GS1 gs 0.023 Tw ( PMID: 20464741.)Tj 0.112 Tw -1.847 -1.25 Td (8.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (Sainio)Tj /Span<>> BDC ( )Tj EMC [(P. F)-19(istul)-16(a-in-ano in a)]TJ /Span<>> BDC ( )Tj EMC [(def)-28(ined popul)-16(a)15(t)-32(ion. Inc)-23.9(idence and )]TJ 0.346 Tw -1.296 -1.25 Td [(epidemiol)30.1(o)-16(gical aspec)-16(ts. )]TJ /T1_3 1 Tf (Ann Chir Gynaecol)Tj /T1_1 1 Tf (. 1984;73\(4\):219\22624. )Tj 0.023 Tw 29.055 25 Td (PMID: 6508203.)Tj 0.198 Tw T* (9.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Her)-32(old)]TJ /Span<>> BDC ( )Tj EMC [(A, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Col)30(op)25(r)-32(o)-15.9(c)-16(t)17(ol)30(o)-16(g)16(y, Eur)-32(opean Manual of)]TJ /Span<>> BDC ( )Tj EMC [(Medic)-24(ine. )]TJ 0.023 Tw -1.296 -1.25 Td [(Sp)25(r)-37(inger, 2017: 59-74.)]TJ 0.01 Tw T* (10.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Bleier)Tj /Span<>> BDC ( )Tj EMC [(JI, M)-23.9(ol)30(o)-16(o)]TJ /Span<>> BDC ( )Tj EMC [(H, Goldber)-32(g)]TJ /Span<>> BDC ( )Tj EMC [(SM. L)-32(iga)15(t)-32(ion of)]TJ /Span<>> BDC ( )Tj EMC [(t)-12.9(he inter)-9.9(sphinc)-16(ter)-37(ic )]TJ 0.155 Tw -1.796 -1.25 Td [(f)-28(istul)-15.9(a tr)-33(a)-16.9(c)-16(t: an)]TJ /Span<>> BDC ( )Tj EMC [(ef)-55.9(fec)-16(t)-32(i)-16(ve new technique for com)10(ple)-18(x f)-28(istul)-16(as. )]TJ /T1_3 1 Tf 0 Tw (Dis )Tj 0.023 Tw T* [(Colon R)21.1(ectum.)]TJ /T1_1 1 Tf ( 2010;53\(1\):43\22646.)Tj -0.005 Tw T* (11.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(L)35(o)]TJ /Span<>> BDC ( )Tj EMC [(O, W)22(ei)]TJ /Span<>> BDC ( )Tj EMC [(R, F)10(o)-16(o)]TJ /Span<>> BDC ( )Tj EMC [(D, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. L)-32(iga)15(t)-32(ion of)]TJ /Span<>> BDC ( )Tj EMC [(inter)-9.9(sphinc)-16(ter)-37(ic f)-28(istul)-15.9(a tr)-33(a)-17(c)-16(t )]TJ 0.005 Tw -1.796 -1.25 Td [(p)25(r)-32(o)-16(cedur)-23.9(e for t)-12.9(he)]TJ /Span<>> BDC ( )Tj EMC [(mana)-17(gement of)]TJ /Span<>> BDC ( )Tj EMC [(cr)-24(ypt)17(o)-15.9(gl)-16(andul)-16(ar anal f)-28(istul)-15.9(as. )]TJ /T1_3 1 Tf 0 Tw (Surg )Tj T* (Pract.)Tj /T1_1 1 Tf 0.023 Tw ( 2012;16:120\226121.)Tj 0.165 Tw T* (12.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(S)-16(ir)-37(ipong)]TJ /Span<>> BDC ( )Tj EMC [(S. )0.5(T)47(he)]TJ /Span<>> BDC ( )Tj EMC 6.761 0 Td [(r)-37(isk )0.5(f)16(a)-17(c)-16(t)17.1(or)-10(s for )0.5(f)16(ail)35(ur)-24(e )0.5(and )0.5(r)-24(ecur)-24(r)-24(ence )0.5(of)]TJ /Span<>> BDC ( )Tj EMC 17.375 0 Td (LIFT )Tj 0.116 Tw -25.933 -1.25 Td [(p)25(r)-32(o)-16(cedur)-23.9(e for f)-28(istul)-16(a in ano. )]TJ /T1_3 1 Tf [(T)57(urk J Surg.)]TJ /T1_1 1 Tf ( 2023 Mar 3;39\(1\):27\22633. )Tj 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td [(10.47717/tur)-23.9(kjsur)-32(g.2023.5807)]TJ 0 0 0 1 k /GS1 gs -0.019 Tw -1.847 -1.25 Td (13.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(W)-16(ilhelm)]TJ /Span<>> BDC ( )Tj EMC (A. A)Tj /Span<>> BDC ( )Tj EMC [(new technique for sphinc)-16(ter-p)25.1(r)-24(eser)-32(v)-16(ing anal f)-27.9(istul)-16(a )]TJ 0.085 Tw -1.796 -1.25 Td [(r)-24(ep)32(air using a)]TJ /Span<>> BDC ( )Tj EMC [(novel r)-33(adial emi)-24(t)-30(t)-32(ing l)-15.9(aser p)25(r)-32(obe. )]TJ /T1_3 1 Tf [(T)54(echniq)14(ues in colo)]TJ 0 Tw (-)Tj T* [(p)46(roctology.)]TJ /T1_1 1 Tf 0.023 Tw ( 2011;15\(4\):445\226449.)Tj 0.083 Tw T* (14.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Giamund)-15.9(o)]TJ /Span<>> BDC ( )Tj EMC [(P, Ger)-32.9(a)-17(c)-24(i)]TJ /Span<>> BDC ( )Tj EMC [(M, T)35(ibaldi)]TJ /Span<>> BDC ( )Tj EMC [(L, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Cl)30(osur)-23.9(e of)]TJ /Span<>> BDC ( )Tj EMC [(f)-28(istul)-15.9(a-in-ano )]TJ 0.12 Tw -1.796 -1.25 Td [(wi)-24(t)-12.9(h l)-16(aser)]TJ /Span<>> BDC ( )Tj EMC [(\227 F)-19(iL)-32(aC: an)]TJ /Span<>> BDC ( )Tj EMC [(ef)-56(fec)-16(t)-31.9(i)-16(ve novel sphinc)-16(ter-sav)-15.9(ing p)25(r)-32(o)-16(cedur)-23.9(e )]TJ 0.023 Tw T* [(for com)10(ple)-17.9(x disease. )]TJ /T1_3 1 Tf (Colorectal disease)Tj /T1_1 1 Tf (. 2014;16\(2\):110\226115.)Tj 0.121 Tw T* (15.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Giamund)-15.9(o)]TJ /Span<>> BDC ( )Tj EMC [(P, Angel)-31(is)]TJ /Span<>> BDC ( )Tj EMC [(M. T)50(r)-24(ea)15(tment of)]TJ /Span<>> BDC ( )Tj EMC [(anal f)-28(istul)-15.9(a wi)-24(t)-13(h F)-19(iL)-32(aC\256: )]TJ 0.098 Tw -1.796 -1.25 Td [(r)-24(esul)56.1(ts of)]TJ /Span<>> BDC ( )Tj EMC (a)Tj /Span<>> BDC ( )Tj EMC [(10-year e)-18(xper)-36.9(ience wi)-24(t)-13(h 175 p)32(a)15(t)-32(ients. )]TJ /T1_3 1 Tf [(T)54(ech Colop)46(roctol.)]TJ /T1_1 1 Tf 0 Tw ( )Tj 0.023 Tw T* [(2021 A)10(ug;25\(8\):941\226948. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1007/s10151-021-02461-4)Tj /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\206)10(\002\036\033 \035\030\032\003\033)30(\n)42(\032)-21(\230\033\241)]TJ 57.136 0 Td (REVIEW)Tj /T1_5 1 Tf 25 0 0 25 505.5021 56.0378 Tm (175)Tj ET endstream endobj 1175 0 obj <>/Border[0 0 0]/H/N/Rect[57.2978 173.061 173.281 163.765]/Subtype/Link/Type/Annot>> endobj 1176 0 obj <>/Border[0 0 0]/H/N/Rect[57.2978 143.061 126.986 133.765]/Subtype/Link/Type/Annot>> endobj 1177 0 obj <>/Border[0 0 0]/H/N/Rect[57.2978 113.061 172.289 103.765]/Subtype/Link/Type/Annot>> endobj 1178 0 obj <>/Border[0 0 0]/H/N/Rect[289.739 183.061 389.898 173.765]/Subtype/Link/Type/Annot>> endobj 1179 0 obj <>/Border[0 0 0]/H/N/Rect[375.927 93.0612 473.398 83.7652]/Subtype/Link/Type/Annot>> endobj 1184 0 obj <> endobj 1183 0 obj <> endobj 1182 0 obj <> endobj 1181 0 obj <> endobj 1180 0 obj <> endobj 1172 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.344 Tw 10 0 0 10 70.8661 724.8299 Tm (\021\030\026\027\f\f\235\017\027\022\021\036\030\027\t\b \f\r\017\013\036\ \005 \023\030\016\n\024\005 \022\017\001\022\017 \022\030\017\023\021\024\ )Tj 0 Tw (-)Tj -0.038 Tw 0 -1.218 TD (\020\035\026\027\007\031\035\016\030\027\024\020\024 \023\030\024\017\f\b\ \024\032\007\036\027\017\016. \200)Tj /Span<>> BDC ( )Tj EMC (\017\f\f\035\036\007\024\r\026\027\017\036 \002\t\035\017 )Tj 0.035 Tw T* (\r\022\035\033\004\036\027\t 93)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\026 \f)Tj /Span<>> BDC ( )Tj EMC (\021\030\026\027\f\f\235\017\027\022\021\036\030\027\t\n\017 \f\r\017\013\ \026)Tj 0 Tw (-)Tj 0.103 Tw T* (\n\017. \210\002\013\026\016 \004\026\f\021\024\021\026 \026\032\017\r\035\ \036\027\017\016 \f\024\f\021\026\r\017\035\026 41,0% \(30 )Tj 0.273 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (74)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r\) \004\036\030\036 6 \n\036\f\016\006\ \036\r \017)Tj /Span<>> BDC ( )Tj EMC (\031\r\036\035\017\004\017\035\026\f\034 )Tj 0.057 Tw T* (\007\024)Tj /Span<>> BDC ( )Tj EMC (49,0% \(36 \017)Tj /Span<>> BDC ( )Tj EMC (73 \023\026\006\017\036\027\021\024\r\) \004\036\030\036 12)Tj /Span<>> BDC ( )Tj EMC (\n\036\f\016\006\036\r \027\026)Tj 0 Tw (-)Tj 0.119 Tw 0 -1.218 TD (\002\035\033\007\036\027\017\016. \211)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\r\t\f\024\022\017\n\017 \021\030\026\027\f\f\235\017\027\022\021\036\030\ )Tj 0 Tw (-)Tj -0.034 Tw 0 -1.218 TD [(\027\t\n\017 \f\r\017\013\026\n\017 \026\032\017\r\035\036\027\017\036 \ )0.5(\027\026\002\035\033\007\026\035\024\f\034 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC [(66,0% )0.5(\f\035\031)]TJ 0 Tw (-)Tj -0.013 Tw T* (\004\026\036\r \(19 \017)Tj /Span<>> BDC ( )Tj EMC (29)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r\), \004\021\024 \027\026\004\017\021\ \036\035\034\027\024 \004\026\013\036, \004\036\n )Tj -0.015 Tw T* (\031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\027\017\022\017\n\017 \021\030\026\027\f\f\235\017\027\022\021\036\030\ \027\t\n\017 \f\r\017\013\026\n\017, )Tj 0.13 Tw T* [(\020\007\036 )0.5(\026\032\017\r\035\036\027\017\036 )0.5(\f\024\f\021\026\r\017\035\024 )0.6(38,0% )0.5(\(16 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 17.428 0 Td [(42 )0.5(\023\026\006\017\036\027)]TJ 0 Tw (-)Tj 0.194 Tw -17.428 -1.218 Td (\021\024\r\). \211)Tj /Span<>> BDC ( )Tj EMC (8,6% \023\026\006\017\036\027\021\024\r \027\026\002\035\033\007\026\035\ \026\f\034 \n\017\020\030\026\006\017\016 \017\n)Tj 0 Tw (-)Tj 0.009 Tw 0 -1.218 TD (\023\035\026\027\021\026 \017)Tj /Span<>> BDC ( )Tj EMC (\035\024\032\026 \f\r\017\013\036\r\024\020\024 \b\024\007\026. \215\030\ \017\027\026\022\024\r \030\026\r\017\021\017\016 )Tj -0.022 Tw 0 -1.218 TD [(\027\036\007\024\f\021\026\021\024\004\027\024\f\021\017 )0.5(\026\027\026\035\034\027\024\020\024 \f\235\017\027\022\021\036\030\026 \ \027\036 \024\021\n\036\004\026\035\024\f\034 )]TJ 0.024 Tw 0 -1.218 TD (\023\024)Tj /Span<>> BDC ( )Tj EMC (\017\f\021\036\004\036\027\017\033 12-\021\017 \n\036\f\016\004\027\024\020\ \024 \023\036\030\017\024\007\026 \027\026\002\035\033\007\036\027\017\016\ . )Tj -0.006 Tw T* [(\202\r\021\024\030\t )0.5(\f\004\017\021\026\033\021 )0.6(\007\026\027\027\031\033 )0.5(\n\036\021\024\007\017\022\031 )0.5(\007\024\f\021\026\021\024\004\027\024 )0.5(\220\235\235\036\022)]TJ 0 Tw (-)Tj 0.248 Tw T* (\021\017\r\027\024\005, \031\004\017\021\t\r\026\016 \023\030\024\f\021\024\ \021\031 \017)Tj /Span<>> BDC ( )Tj EMC (\036\036 \n\026\035\031\033 \021\030\026\r\n\026\021\017\004)Tj 0 Tw (-)Tj T* (\027\024\f\021\034 [29].)Tj 0.002 Tc 0.002 Tw T* [(Ja)15(yne)]TJ /Span<>> BDC ( )Tj EMC 2.577 0 Td [(D. )0.5(\017 \f\024\026\r\021. )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC [(2021 \020. \023\030\024\r\036\035\017 )0.5(\030\026\027\007\024\n\017\017\030\024\r\026\027)]TJ 0 Tc 0 Tw (-)Tj 0.002 Tc -0.038 Tw -2.577 -1.218 Td (\027\024\036 \017\f\f\035\036\007\024\r\026\027\017\036, \r)Tj /Span<>> BDC ( )Tj EMC [(\022\024\021\024\030\024\n \f\030\026\r\027\017\035\017 \022\024\035\035\ \026\020\036\027\024\r\t\005)2( )]TJ -0.033 Tw T* [(\017\n\023\035\026\027\021 \(Sur)-31.9(gisis ES\256\) \017)]TJ /Span<>> BDC ( )Tj EMC [(\022\035\026\f\f\017\004\036\f\022\017\036 \b\017\030\031\030\020\017\004\ \036\f\022\017\036)2( )]TJ 0.18 Tw T* [(\n\036\021\024\007\t \035\036\004\036\027\017\016 \021\030\026\027\f\f\235\ \017\027\022\021\036\030\027\t\b \f\r\017\013\036\005 \023\030\016\n\024\ \005)2( )]TJ 0.093 Tw T* (\022\017\001\022\017, \r\022\035\033\004\026\016 \027\017\r\036\007\036\ \027\017\036 \f\035\017\017\f\021\024\020\024 \035\024\f\022\031\021\026\ , \023\036)Tj 0 Tc 0 Tw (-)Tj 0.002 Tc 0.05 Tw T* (\030\036\f\036\022\026\033\013\031\033 \035\017\020\026\021\031\030\031,\ \017\f\f\036\004\036\027\017\036 \f\r\017\013\026 \017)Tj /Span<>> BDC ( )Tj EMC (\035\017\020\017\030\024\r\026)Tj 0 Tc 0 Tw (-)Tj 0.002 Tc -0.042 Tw T* (\027\017\036 \f\r\017\013\036\r\024\020\024 \b\024\007\026 \r)Tj /Span<>> BDC ( )Tj EMC [(\n\036\032\f\235\017\027\022\021\036\030\027\024\n \023\030\024\f\021\030\ \026\027\f\021\r\036)2( )]TJ 0.103 Tw T* (\(LIFT\). \200)Tj /Span<>> BDC ( )Tj EMC (\017\f\f\035\036\007\024\r\026\027\017\036 \002\t\035\024 \r\022\035\033\ \004\036\027\024 304)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027)Tj 0 Tc 0 Tw (-)Tj 0.002 Tc 0.21 Tw T* [(\021\026. \200\t\007\024\030\024\r\035\036\027\017\036 \004\036\030\036\  12 \n\036\f\016\006\036\r \027\026\002\035\033\007\026\035\024\f\034)2( )]TJ 0.029 Tw T* (\031)Tj /Span<>> BDC ( )Tj EMC (54,0% \023\026\006\017\036\027\021\024\r \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \f)Tj /Span<>> BDC ( )Tj EMC (\022\024\035\035\026\020\036\027\024\r\t\n \017\n\023\035\026\027)Tj 0 Tc 0 Tw (-)Tj 0.002 Tc 0.003 Tw T* (\021\024\n \(66/122\) \017)Tj /Span<>> BDC ( )Tj EMC [(\r \020\030\031\023\023\036 \022\035\026\f\f\017\004\036\f\022\017\b \b\017\ \030\031\030\020\017\004\036\f\022\017\b)2( )]TJ 0.421 Tw T* (\n\036\021\024\007\024\r)Tj /Span<>> BDC ( )Tj EMC (\227 64,0% \023\026\006\017\036\027\021\024\r \(27/42 \023\036\030\036\f\ \036\022\026\033)Tj 0 Tc 0 Tw (-)Tj 0.002 Tc 0.12 Tw T* (\013\036\005 \035\017\020\026\021\031\030\t, 75,0%)Tj /Span<>> BDC ( )Tj EMC (\227 \017\f\f\036\004\036\027\017\036 \f\r\017\013\026, 53,0%)Tj /Span<>> BDC ( )Tj EMC [(\227)2( )]TJ 0.456 Tw T* (\027\017\r\036\007\036\027\017\036 \f\035\017\017\f\021\024\020\024 \035\ \024\f\022\031\021\026, 42,0%)Tj /Span<>> BDC ( )Tj EMC [(\227 LIFT\).)2( )]TJ 0.086 Tw T* (\225\235\235\036\022\021\017\r\027\024\f\021\034 \035\036\004\036\027\017\ \016 \r\026\030\034\017\030\024\r\026\035\026 \r)Tj /Span<>> BDC ( )Tj EMC [(\026\r\017\f\017\n\024\f\021\017)2( )]TJ -0.035 Tw T* (\024\021 \n\036\021\024\007\026 \017)Tj /Span<>> BDC ( )Tj EMC (\021\017\023\026 \f\r\017\013\026. \025\024\035\035\026\020\036\027\024\r\ \t\005 \017\n\023\035\026\027\021 \023\024\022\026)Tj 0 Tc 0 Tw (-)Tj 0.002 Tc 0.031 Tw T* [(\026\035 \220\235\235\036\022\021\017\r\027\024\f\021\034 )0.5(\027\026)]TJ /Span<>> BDC ( )Tj EMC [(\031\030\024\r\027\036 60,0\22680,0% )0.5(\023\030\017)]TJ /Span<>> BDC ( )Tj EMC (\021\030\026\027\f)Tj 0 Tc 0 Tw (-)Tj 0.002 Tc 0.025 Tw T* [(\f\235\017\027\022\021\036\030\027\t\b )0.5(\f\r\017\013\026\b, )0.5(\021\024\020\007\026 )0.5(\022\026\022 )0.5(\007\035\016 )0.5(\220\022\f\021\030\026\f\235\017\027\022\021\036\030)]TJ 0 Tc 0 Tw (-)Tj 0.002 Tc 0.249 Tw T* [(\027\t\b \f\r\017\013\036\005 \220\021\024\021 \023\024\022\026\026\021\ \036\035\034 \f\024\f\021\026\r\017\035 40,0\22660,0%.)2( )]TJ 0.126 Tw T* (\211)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC [(\002\024\035\036\027\034\033 \025\030\024\027\026 \004\026\f\021\024\021\ \026 \026\032\017\r\035\036\027\017\016)2.1( )]TJ 0.513 Tw T* (\023\030\017)Tj /Span<>> BDC ( )Tj EMC (\017\f\023\024\035\034\024\r\026\027\017\017 \022\024\035\035\026\020\036\ \027\024\r\024\020\024 \017\n\023\035\026\027\021\026 \f\024)Tj 0 Tc 0 Tw (-)Tj 0.002 Tc 0.214 Tw T* (\f\021\026\r\035\016\035\026 30,0\22650,0%. \210\f\027\024\r\027\t\n \027\ \036\007\024\f\021\026\021\022\024\n \n\036\021\024)Tj 0 Tc 0 Tw (-)Tj 0.002 Tc 0.202 Tw T* [(\007\026 )0.5(\f\021\026\035\026 )0.5(\n\017\020\030\026\006\017\016 )0.5(\017\n\023\035\026\027\021\026, )0.5(\022\024\021\024\030\026\016 )0.5(\027\026\002\035\033\007\026\035\026\f\034)2( )]TJ 0.103 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC [(16,0% \f\035\031\004\026\036\r, \004\021\024 \f\027\017\032\026\035\024 \ \031\f\023\036\b \035\036\004\036\027\017\016. \224\030\036\007\017)2( )]TJ 0.159 Tw T* (\022\035\026\f\f\017\004\036\f\022\017\b \n\036\021\024\007\024\r \035\031\ \004\001\017\005 \030\036\031\035\034\021\026\021 \023\030\024\007\036\n\ \024\027)Tj 0 Tc 0 Tw (-)Tj 0.002 Tc 0.034 Tw T* (\f\021\030\017\030\024\r\026\035\024 \017\f\f\036\004\036\027\017\036 \f\ \r\017\013\026 \f)Tj /Span<>> BDC ( )Tj EMC [(\004\026\f\021\024\021\024\005 \026\032\017\r\035\036\027\017\016)2( )]TJ 0.302 Tw T* (75,0%, \026)Tj /Span<>> BDC ( )Tj EMC 4.179 0 Td (\b\031\007\001\017\005)Tj /Span<>> BDC ( )Tj EMC 3.639 0 Td [(\227 \035\017\020\017\030\024\r\026\027\017\036 \f\r\017\013\036\r\024\020\ \024 )0.5(\b\024\007\026)2( )]TJ -0.006 Tw -7.818 -1.218 Td (\r)Tj /Span<>> BDC ( )Tj EMC [(\n\036\032\f\235\017\027\022\021\036\030\027\024\n \023\030\024\f\021\030\ \026\027\f\021\r\036, \020\007\036 \220\235\235\036\022\021\017\r\027\024\ \f\021\034)2( )]TJ -0.014 Tw T* (\f\024\f\021\026\r\017\035\026 42,0%. \203\017\r\036\007\036\027\017\036\ \f\035\017\017\f\021\024\020\024 \035\024\f\022\031\021\026 \023\024)Tj 0 Tc 0 Tw (-)Tj 0.002 Tc 0.27 Tw T* (\022\026\026\035\024 \f\030\036\007\027\033\033 \220\235\235\036\022\021\ \017\r\027\024\f\021\034 \027\026)Tj /Span<>> BDC ( )Tj EMC [(\031\030\024\r\027\036 53,0%.)2( )]TJ 0.04 Tw T* (\202\r\021\024\030\t \f\007\036\035\026\035\017 \r\t\r\024\007, \004\021\ \024 \035\036\004\036\027\017\036 \f)Tj /Span<>> BDC ( )Tj EMC (\017\f\023\024\035\034\024\r\026\027\017)Tj 0 Tc 0 Tw (-)Tj 0.002 Tc 0.106 Tw T* (\036\n \022\024\035\035\026\020\036\027\024\r\024\020\024 \017\n\023\035\ \026\027\021\026 \f\024\023\024\f\021\026\r\017\n\024 \023\024)Tj /Span<>> BDC ( )Tj EMC (\220\235\235\036\022)Tj 0 Tc 0 Tw (-)Tj 0.002 Tc 0.208 Tw T* (\021\017\r\027\024\f\021\017 \f)Tj /Span<>> BDC ( )Tj EMC (\007\030\031\020\017\n\017 \b\017\030\031\030\020\017\004\036\f\022\017\n\ \017 \n\036\021\024\007\026\n\017, \024\007)Tj 0 Tc 0 Tw (-)Tj 0.002 Tc 0.095 Tw T* [(\027\026\022\024 \r\t\f\024\022\026\016 \f\021\024\017\n\024\f\021\034 \017\ \n\023\035\026\027\021\026 \024\020\030\026\027\017\004\017\r\026\036\021\ \036\020\024)2( )]TJ 0.244 Tw T* (\023\030\017\n\036\027\036\027\017\036. \215\030\017)Tj /Span<>> BDC ( )Tj EMC [(\220\021\024\n \027\036\024\002\b\024\007\017\n\024\f\021\034 \007\026\035\ \034\027\036\005\001\017\b)2( )]TJ 0.236 Tw T* (\017\f\f\035\036\007\024\r\026\027\017\005 \r)Tj /Span<>> BDC ( )Tj EMC [(\024\002\035\026\f\021\017 \035\036\004\036\027\017\016 \f\035\024\032\027\ \t\b \f\r\017\013\036\005)2( )]TJ 0.099 Tw 23.244 64.543 Td (\023\024\007\004\036\030\022\017\r\026\036\021\f\016 \007\035\016 \024\023\ \030\036\007\036\035\036\027\017\016 \024\023\021\017\n\026\035\034\027\t\ \b \023\024\007)Tj 0 Tc 0 Tw (-)Tj 0.002 Tc T* (\b\024\007\024\r [27].)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 303.3769 676.1179 Tm [(\020)21(\026\027\r\241\224\034\022\031\034)]TJ 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0 Tc 0.401 Tw 10 0 0 10 303.3071 651.7618 Tm [(\224\r\017\013 )0.5(\023\030\016\n\024\005 )0.5(\022\017\001\022\017)]TJ /Span<>> BDC ( )Tj EMC 9.728 0 Td [(\227 )0.5(\023\026\021\024\035\024\020\017\004\036\f\022\017\005 )0.6(\023\030\024\006\036\f\f, )]TJ 0.388 Tw -9.728 -1.218 Td (\r\024\r\035\036\022\026\033\013\017\005 \f\235\017\027\022\021\036\030\027\ \t\005 \026\023\023\026\030\026\021 \023\030\016\n\024\005 \022\017\001)Tj 0 Tw (-)Tj 0.59 Tw T* (\022\017. \216\017\030\031\030\020\017\004\036\f\022\024\036 \r\n\036\001\ \026\021\036\035\034\f\021\r\024, \027\026\023\030\026\r\035\036\027\027\ \024\036 )Tj 0.214 Tw 0 -1.218 TD (\027\026)Tj /Span<>> BDC ( )Tj EMC (\035\017\022\r\017\007\026\006\017\033 \f\r\017\013\036\r\024\020\024 \b\ \024\007\026, \027\036\030\036\007\022\024 \023\030\017\r\024\007\017\021\ )Tj 0.219 Tw 0 -1.218 TD (\022)Tj /Span<>> BDC ( )Tj EMC (\030\026\r\017\021\017\033 \027\036\007\024\f\021\026\021\024\004\027\024\ \f\021\017 \026\027\026\035\034\027\024\020\024 \f\235\017\027\022\021\036\ \030\026. )Tj 0.228 Tw 0 -1.218 TD (\215\030\017\n\036\027\036\027\017\036 \235\017\002\030\017\027\024\r\024\ \020\024 \022\035\036\016, \022\024\035\035\026\020\036\027\024\r\024\020\ \024 \017\n)Tj 0 Tw (-)Tj 0.139 Tw T* (\023\035\026\027\021\026 \027\036 \f\r\016\026\027\024 \f)Tj /Span<>> BDC ( )Tj EMC (\023\024\r\030\036\032\007\036\027\017\036\n \f\021\030\031\022\021\031\030\ \026\027\026\035\034)Tj 0 Tw (-)Tj 0.082 Tw T* (\027\024\020\024 \f\235\017\027\022\021\036\030\026, \004\021\024 \024\002\ \031\f\035\026\r\035\017\r\026\036\021 \017\b \r\t\f\024\022\031\033 \002\ \036)Tj 0 Tw (-)Tj 0.004 Tw T* [(\024\023\026\f\027\024\f\021\034. )0.6(\200)]TJ /Span<>> BDC ( )Tj EMC 5.484 0 Td [(\f\035\031\004\026\036 )0.5(\030\026\r\017\021\017\016 )0.6(\030\036\006\017\007\017\r\026 )0.5(\026\002\024\035\036\r\026\027\017\016, )]TJ 0.303 Tw -5.484 -1.218 Td (\036\f\021\034 \r\024\n\024\032\027\024\f\021\034 \023\024\r\021\024\030\ \027\024\020\024 \017\f\023\024\035\034\024\r\026\027\017\036 \002\017\024\ )Tj 0 Tw (-)Tj 0.147 Tw 0 -1.218 TD [(\n\026\021\036\030\017\026\035\024\r )0.5(\017\035\017 )0.6(\023\030\017\n\036\027\036\027\017\036 )0.6(\017\027\t\b )0.5(\n\036\021\024\007\024\r )0.5(\035\036\004\036\027\017\016 )]TJ 0 Tw 0 -1.218 TD (\f\r\017\013\036\005 \023\030\016\n\024\005 \022\017\001\022\017.)Tj 0.078 Tw T* (\207\024\035\034\001\017\027\f\021\r\024 \026\r\021\024\030\024\r \024\021\ \n\036\004\026\036\021, \004\021\024 \023\030\017\n\036\027\036\027\017\036\ \235\017)Tj 0 Tw (-)Tj 0.032 Tw T* [(\002\030\017\027\024\r\024\020\024 )0.5(\022\035\036\016 )0.6(\027\036 )0.5(\021\030\036\002\031\036\021 )0.5(\020\024\f\023\017\021\026\035\017\026\006\017\017 )0.6(\023\026\006\017\036\027\021\026 )]TJ -0.025 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC 0.681 0 Td [(\f\021\026\006\017\024\027\026\030 )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC 5.215 0 Td [(\036\020\024 )0.5(\017\f\023\024\035\034\024\r\026\027\017\036 )0.5(\r\024\n\024\032\027\024 )0.6(\r)]TJ /Span<>> BDC ( )Tj EMC 13.013 0 Td (\031\f\035\024\r\017)Tj 0 Tw (-)Tj -0.051 Tw -18.909 -1.218 Td (\016\b \007\027\036\r\027\024\020\024 \f\021\026\006\017\024\027\026\030\ \026, \024\021\f\031\021\f\021\r\017\036 \030\026\027 \017)Tj /Span<>> BDC ( )Tj EMC (\027\017\022\017\005 \031\030\024)Tj 0 Tw (-)Tj 0.219 Tw T* [(\r\036\027\034 \002\024\035\036\r\024\020\024 \f\017\027\007\030\024\n\026\ \007\024\023\024\035\027\017\021\036\035\034\027\024 )0.5(\f\024\022\030\026\013\026\036\021 )]TJ 0.008 Tw T* (\023\036\030\017\024\007 \030\036\026\002\017\035\017\021\026\006\017\017\ \017)Tj /Span<>> BDC ( )Tj EMC (\027\036\021\030\031\007\024\f\023\024\f\024\002\027\024\f\021\017. \210\ \007\027\026\022\024 )Tj 0.082 Tw T* (\r\t\f\024\022\024\036 \004\017\f\035\024 \030\036\006\017\007\017\r\024\ \r \026\002\024\035\036\r\026\027\017\016 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\035\036\004\036\027\017\017 )Tj 0.111 Tw T* (\f\r\017\013\036\005 \023\030\016\n\024\005 \022\017\001\022\017 \f)Tj /Span<>> BDC ( )Tj EMC (\023\030\017\n\036\027\036\027\017\036\n \235\017\002\030\017\027\024\r\024\ \020\024 )Tj -0.016 Tw T* (\022\035\036\016 \024\002\031\f\035\026\r\035\017\r\026\036\021 \007\026\ \035\034\027\036\005\001\036\036 \017\031\004\036\027\017\036 \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\r\036\007\036)Tj 0 Tw (-)Tj 0.087 Tw T* [(\027\017\036 )0.5(\017\f\f\035\036\007\024\r\026\027\017\005, )0.6(\r\t\016\r\035\016\033\013\017\b )0.6(\235\026\022\021\024\030\t )0.5(\030\017\f\022\026 )0.6(\r\024)]TJ 0 Tw (-)Tj T* (\r\030\026\021\026 \026\002\024\035\036\r\026\027\017\016.)Tj 0.251 Tw T* (\236\f\f\035\036\007\024\r\026\027\017\005, \f\030\026\r\027\017\r\026\033\ \013\017\b \024\023\036\030\026\021\017\r\027\t\036 \r\n\036\001\026)Tj 0 Tw (-)Tj 0.028 Tw T* [(\021\036\035\034\f\021\r\026 )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC [(\017\f\023\024\035\034\024\r\026\027\017\036\n )0.5(\235\017\002\030\017\027\024\r\024\020\024 )0.5(\022\035\036\005 \017)]TJ /Span<>> BDC ( )Tj EMC (\022\024\035)Tj 0 Tw (-)Tj 0.13 Tw T* [(\035\026\020\036\027\024\r\024\020\024 \017\n\023\035\026\027\021\026, )0.5(\027\036\007\024\f\021\026\021\024\004\027\024 \007\035\016 \023\030\024\ \r\036\007\036\027\017\016 )]TJ 0 Tw T* (\n\036\021\026\026\027\026\035\017\026 [18\22620].)Tj 0.39 Tw T* (\215\030\017\n\036\027\036\027\017\036 \235\017\002\030\017\027\024\r\024\ \020\024 \022\035\036\016, \f\024\020\035\026\f\027\024 \007\026\027\027\ \t\n )Tj 0.137 Tw T* (\n\036\021\026)Tj /Span<>> BDC ( )Tj EMC 1.881 0 Td [(\026\027\026\035\017\026 Cir)-31.9(o)-16(cchi \017)]TJ /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. [34], \024\023\030\026\r\007\026\027\024, \023\030\036\ )Tj /Span<>> BDC (-)Tj EMC -0.049 Tw -1.881 -1.218 Td (\017\n\031\013\036\f\021\r\036\027\027\024, \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\f\021\t\b \235\024\030\n\026\b \f\r\017\013\036\005)Tj /Span<>> BDC ( )Tj EMC (\227 \017\027\021\030\026)Tj /Span<>> BDC (-)Tj EMC 0.32 Tw T* (\f\235\017\027\022\021\036\030\027\t\b \017)Tj /Span<>> BDC ( )Tj EMC (\027\017\022\017\b \021\030\026\027\f\f\235\017\027\022\021\036\030\027\ \t\b. \200)Tj /Span<>> BDC ( )Tj EMC (\220\021\017\b )Tj 0.344 Tw T* (\f\035\031\004\026\016\b \n\036\021\024\007 \007\036\n\024\027\f\021\030\ \017\030\031\036\021 \031\007\024\r\035\036\021\r\024\030\017\021\036\035\ \034\027\t\036 )Tj 0.093 Tw T* (\023\024\022\026\026\021\036\035\017 \026\032\017\r\035\036\027\017\016\ \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\n\017\027\017\n\026\035\034\027\024\n \030\017\f\022\036 \024\f)Tj 0 Tw (-)Tj 0.261 Tw T* (\035\024\032\027\036\027\017\005 \017)Tj /Span<>> BDC ( )Tj EMC (\002\036 \031\020\030\024\t \030\026\r\017\021\017\016 \027\036\007\024\ \f\021\026\021\024\004\027\024\f\021\017 )Tj 0.133 Tw T* (\026\027\026\035\034\027\024\020\024 \f\235\017\027\022\021\036\030\026.\ \210\007\027\026\022\024 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\f\035\024\032\027\t\b \f\r\017\013\026\b, )Tj -0.04 Tw T* (\024\f\024\002\036\027\027\024 \r\t\f\024\022\017\b \021\030\026\027\f\f\ \235\017\027\022\021\036\030\027\t\b \017)Tj /Span<>> BDC ( )Tj EMC (\220\022\f\021\030\026\f\235\017\027\022)Tj /Span<>> BDC (-)Tj EMC 0.387 Tw T* (\021\036\030\027\t\b, \220\235\235\036\022\021\017\r\027\024\f\021\034 \235\ \017\002\030\017\027\024\r\024\020\024 \022\035\036\016 \027\026\004\017\ )Tj 0 Tw (-)Tj 0.058 Tw T* (\021\036\035\034\027\024 \f\027\017\032\026\036\021\f\016, \004\021\024 \ \024\020\030\026\027\017\004\017\r\026\036\021 \036\020\024 \023\030\017\ \n\036\027\036\027\017\036 )Tj 0.189 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\024\002\024\f\027\024\r\t\r\026\036\021 \r\t\002\024\030 \r)Tj /Span<>> BDC ( )Tj EMC (\023\024\035\034\031 \002\024\035\036\036 \017\027\r\026\017\r\027\t\b\ )Tj 0 Tw T* (\b\017\030\031\030\020\017\004\036\f\022\017\b \r\n\036\001\026\021\036\035\ \034\f\021\r.)Tj 0.069 Tw 0 -1.218 TD (\236\f\023\024\035\034\024\r\026\027\017\036 \022\024\035\035\026\020\036\ \027\024\r\024\020\024 \017\n\023\035\026\027\021\026 \021\026\022\032\036\ \024\020\030\026)Tj 0 Tw (-)Tj -0.008 Tw 0 -1.218 TD (\027\017\004\017\r\026\036\021\f\016 \f\035\024\032\027\024\f\021\034\033\ \f\r\017\013\026 \023\030\016\n\024\005 \022\017\001\022\017. \200)Tj /Span<>> BDC ( )Tj EMC (\030\016\007\036 )Tj 0.069 Tw 0 -1.218 TD [(\017\f\f\035\036\007\024\r\026\027\017\005 )0.6(\023\024\007\004\201\030\022\017\r\026\036\021\f\016, )0.5(\004\021\024 )0.6(\031\f\023\036\b )0.5(\035\036\004\036\027\017\016 )0.6(\r\024 )]TJ -0.023 Tw 0 -1.218 TD (\n\027\024\020\024\n \026\r\017\f\017\021 \024\021 \022\024\030\030\036\ \022\021\027\024\005 \021\036\b\027\017\022\017 \031\f\021\026\027\024\r\ \022\017 \017\n)Tj 0 Tw (-)Tj 0.157 Tw 0 -1.218 TD (\023\035\026\027\021\026: \027\036\024\002\b\024\007\017\n \021\013\026\021\ \036\035\034\027\t\005 \022\033\030\036\021\026\032 \f\r\017\013\036\r\024\ \020\024 )Tj 0.001 Tw 0 -1.218 TD [(\b\024\007\026, \023\035\024\021\027\026\016 )0.5(\235\017\022\f\026\006\017\016 )0.5(\017\n\023\035\026\027\021\026 )0.5(\r \024\002\035\026\f\021\017 \r\027\031\021\030\036\027)]TJ 0 Tw (-)Tj -0.058 Tw T* (\027\036\020\024 \024\021\r\036\030\f\021\017\016 \017)Tj /Span<>> BDC ( )Tj EMC (\024\002\036\f\023\036\004\036\027\017\036 \007\030\036\027\026\032\026 \ \027\026\030\031\032\027\024\020\024 \024\021)Tj 0 Tw (-)Tj 0.047 Tw T* (\r\036\030\f\021\017\016)Tj /Span<>> BDC ( )Tj EMC ([30]. \224\024\020\035\026\f\027\024 \030\036\031\035\034\021\026\021\026\ \n \f\017\f\021\036\n\026\021\017\004\036\f\022\017\b )Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0 Tw 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\206)10(\002\036\033 \035\030\032\003\033)30(\n)42(\032)-21(\230\033\241)]TJ 57.136 0 Td (REVIEW)Tj -57.136 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 2)69(4, \023\0224, 202)23(5)]TJ 43.013 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 2)69(4, \023\0224, 202)23(5)]TJ /T1_3 1 Tf 25 0 0 25 20.9152 56.0378 Tm (174)Tj ET endstream endobj 1170 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\034\201\021\024\016\215\016\215\021\016 \223\021\235\201\021\215\025\r\025\ \202)10(\025 \017)-10(\t\016\004 \021\022\235\021\025\222\t\001\b)-10(\026\021\f\016\b\017\021 \021\024\222\t\001\215\026)11(\025\r )]TJ 0 -1 TD [(\r\022\t\016\f\016\215\021\021 \b\r\021\232\016\207 \222\201\004\024\025\ \207 \017\021\020\017\021 \(\025\235\213\025\201\022\t\021\026)11(\016\201\001\026)-19.9(\200\201\220\))]TJ 32.168 1 Td [(Fibrin glue and bioplastic implants in tr)31(eatment of\022r)31(ectal f)-21(istulas \(r)31(e)11(vie)11(w\))]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0.122 Tw 10 0 0 10 42.5197 420.3799 Tm [(R)-10(a)15(t)-30(t)17(o)]TJ /Span<>> BDC ( )Tj EMC (C. \017 \f\024\026\r\021. \r)Tj /Span<>> BDC ( )Tj EMC (2012 \020. \023\030\017\n\036\027\016\035 \f\017\027\021\036\021\017\004\ \036\f\022\017\005 )Tj 0.503 Tw 0 -1.218 TD [(\002\017\024\023\024\035\017\n\036\030\027\t\005 \017\n\023\035\026\027\021\ \(Gor)-24(eBio-A F)-19(istul)-16(aPl)35.1(ug\256\) )]TJ 0.18 Tw T* (\(\217\017\f.)Tj /Span<>> BDC ( )Tj EMC (2\). \200)Tj /Span<>> BDC ( )Tj EMC (\017\f\f\035\036\007\024\r\026\027\017\016 \002\t\035\017 \r\022\035\033\ \004\036\027\t 11 \023\026\006\017)Tj 0 Tw (-)Tj 0.038 Tw T* (\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\021\030\026\027\f\f\235\017\027\022\021\036\030\027\t\n\017 \f\r\017\013\ \026\n\017 \023\030\016\n\024\005 \022\017\001\022\017, )Tj 0.265 Tw T* (\022\024\021\024\030\t\036 \002\t\035\017 \023\030\024\f\035\036\032\036\ \027\t \r)Tj /Span<>> BDC ( )Tj EMC (\021\036\004\036\027\017\036 12 \n\036\f\016\006\036\r. )Tj 0.292 Tw T* (\203\017)Tj /Span<>> BDC ( )Tj EMC (\031)Tj /Span<>> BDC ( )Tj EMC (\024\007\027\024\020\024 \023\026\006\017\036\027\021\026 \027\036 \002\t\ \035\024 \024\021\n\036\004\036\027\024 \f\035\031\004\026\036\r )Tj 0.257 Tw T* [(\021\030\026\027\f\035\024\022\026\006\017\017 )0.6(\017\n\023\035\026\027\021\026. )0.5(\200\t\007\024\030\024\r\035\036\027\017\036 )0.6(\027\026\f\021\031\023\017\035\024 )]TJ -0.043 Tw T* (\031)Tj /Span<>> BDC ( )Tj EMC (8 \017)Tj /Span<>> BDC ( )Tj EMC (11 \023\026\006\017\036\027\021\024\r \(72,7%\). \202\r\021\024\030\t \f\ \004\017\021\026\033\021, \004\021\024 \007\026\027)Tj 0 Tw (-)Tj -0.033 Tw T* (\027\026\016 \n\036\021\024\007\017\022\026 \002\036\024\023\026\f\027\026\ \017)Tj /Span<>> BDC ( )Tj EMC (\036\036 \n\024\032\027\024 \017\f\023\024\035\034\024\r\026\021\034 \022\ \026\022 )Tj -0.016 Tw T* (\023\036\030\r\031\033 \035\017\027\017\033 \035\036\004\036\027\017\016\ , \021\026\022 \022\026\022 \027\036 \n\036\027\016\036\021\f\016 \022\024\ \027\235\017\020\031)Tj 0 Tw (-)Tj 0.086 Tw T* (\030\026\006\017\016 \f\r\017\013\036\r\024\020\024 \b\024\007\026, \027\ \036\021 \021\030\026\r\n\026\021\017\004\036\f\022\024\020\024 \r\024\007\ \036\005)Tj 0 Tw (-)Tj 0.06 Tw T* [(\f\021\r\017\016 )0.6(\027\026)]TJ /Span<>> BDC ( )Tj EMC 3.84 0 Td [(\n\t\001\006\t )0.6(\026\027\026\035\034\027\024\020\024 )0.6(\032\024\n\026 )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC 11.094 0 Td [(\023\030\017 )0.6(\027\036\031\007\026\004\036 )0.6(\r\024)]TJ 0 Tw (-)Tj -0.037 Tw -14.933 -1.218 Td (\n\024\032\027\024 \023\030\017\n\036\027\017\021\034 \007\030\031\020\017\ \036 \b\017\030\031\030\020\017\004\036\f\022\017\036 \n\036\021\024\007\ \t)Tj /Span<>> BDC ( )Tj EMC ([23].)Tj 0.026 Tw T* (Ommer)Tj /Span<>> BDC ( )Tj EMC (A. \017 \f\024\026\r\021. \r)Tj /Span<>> BDC ( )Tj EMC (2012)Tj /Span<>> BDC ( )Tj EMC (\020. \023\030\024\r\036\035\017 \n\027\024\020\024\006\036\027\021\030\024\ \r\024\036 )Tj -0.032 Tw T* (\017\f\f\035\036\007\024\r\026\027\017\036, \r\022\035\033\004\026\033\013\ \036\036 40 \023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\r\t\f\024\022\017\n\017 )Tj 0.134 Tw T* [(\021\030\026\027\f\f\235\017\027\022\021\036\030\027\t\n\017 )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC 9.702 0 Td [(\220\022\f\021\030\026\f\235\017\027\021\036\030\027\t\n\017 )0.6(\f\r\017\013\026\n\017 )]TJ 0.06 Tw -9.702 -1.218 Td (\023\030\016\n\024\005 \022\017\001\022\017, \022\024\021\024\030\t\n \002\ \t\035\024 \r\t\023\024\035\027\036\027\024 \b\017\030\031\030\020\017\004\ \036)Tj 0 Tw (-)Tj -0.047 Tw T* [(\f\022\024\036 \r\n\036\001\026\021\036\035\034\f\021\r\024 )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC [(\017\f\023\024\035\034\024\r\026\027\017\036\n )0.5(\022\024\035\035\026\020\036\027\024\r\024\020\024 )]TJ 0.013 Tw T* [(\017\n\023\035\026\027\021\026 Gor)-24(eBioAF)-19(istul)-15.9(aPl)35(ug\256. \215\030\017)]TJ /Span<>> BDC ( )Tj EMC (\022\024\027\021\030\024\035\034\027\024\n \024\f)Tj 0 Tw (-)Tj 0.075 Tw T* (\n\024\021\030\036 \004\036\030\036 6 \n\036\f\016\006\036\r \026\032\017\ \r\035\036\027\017\036 \002\t\035\024 \007\024\f\021\017\020\027\031\021\ \024 )Tj 0.03 Tw T* (\031)Tj /Span<>> BDC ( )Tj EMC (20 \(50,0%\) \023\026\006\017\036\027\021\024\r. \213\013\036 \r)Tj /Span<>> BDC ( )Tj EMC (3 \027\026\002\035\033\007\036\027\017\016\b \f\r\017\013\017 )Tj 0.087 Tw T* (\026\032\017\035\017 \r)Tj /Span<>> BDC ( )Tj EMC (\f\030\024\022 \007\024)Tj /Span<>> BDC ( )Tj EMC (12 \n\036\f\016\006\036\r, \024\002\013\017\005 \023\024\022\026\026\021\ \036\035\034 \026)Tj 0 Tw (-)Tj 0.024 Tw T* [(\032\017\r\035\036\027\017\016 )0.6(\f\024\f\021\026\r\017\035 )0.5(57,5% )0.6(\(23/40\). )0.5(\230\026\022\032\036 )0.5(\017\f\f\035\036\007\024\r\026)]TJ 0 Tw (-)Tj 0.052 Tw T* (\021\036\035\017 \023\030\017\001\035\017 \022)Tj /Span<>> BDC ( )Tj EMC (\r\t\r\024\007\031, \004\021\024 \030\036\031\035\034\021\026\021\t \035\ \036\004\036\027\017\016 \002\t\035\017 )Tj 0.221 Tw T* (\035\031\004\001\036 \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\021\030\026\027\f\f\235\017\027\022\021\036\030\027\t\n\017 \f\r\017\013\ \026\n\017 )Tj 0.001 Tw T* (\(61,9%\), \004\036\n \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\220\022\f\021\030\026\f\235\017\027\022\021\036\030\027\t\n\017 \f\r\017\ )Tj 0 Tw (-)Tj -0.017 Tw T* [(\013\026\n\017 )0.5(\(50,0%\). )0.6(\217\036\031\035\034\021\026\021\t )0.5(\035\036\004\036\027\017\016 )0.5(\002\t\035\017 )0.5(\035\031\004\001\036 )0.6(\031)]TJ /Span<>> BDC ( )Tj EMC (\023\036\030)Tj 0 Tw (-)Tj 0.064 Tw T* (\r\017\004\027\024 \024\023\036\030\017\030\024\r\026\027\027\t\b \023\026\ \006\017\036\027\021\024\r 14/22 \(63,6%\), \004\036\n )Tj 0.009 Tw T* (\031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\030\026\027\036\036 \023\036\030\036\027\036\f\036\027\027\t\n\017 \b\017\ \030\031\030\020\017\004\036\f\022\017\n\017 )Tj 0.304 Tw 23.244 34.098 Td (\r\n\036\001\026\021\036\035\034\f\021\r\026\n\017 \023\024)Tj /Span<>> BDC ( )Tj EMC (\023\024\r\024\007\031 \f\r\017\013\026 \023\030\016\n\024\005 \022\017\001\ \022\017 )Tj 0.035 Tw T* (9/18 \(50,0%\). \203\017 \031)Tj /Span<>> BDC ( )Tj EMC (\024\007\027\024\020\024 \023\026\006\017\036\027\021\026 \027\036 \002\t\ \035\024 \024\021\n\036\004\036)Tj 0 Tw (-)Tj 0.239 Tw T* [(\027\024 )0.5(\023\030\017\027\026\022\024\r )0.6(\023\024\f\035\036\024\023\036\030\026\006\017\024\027\027\024\005 )0.6(\027\036\007\024\f\021\026\021\024\004\027\024\f\021\017 )]TJ 0 Tw T* (\026\027\026\035\034\027\024\020\024 \f\235\017\027\022\021\036\030\026 \ [24].)Tj 0.007 Tw T* [(Cintr)-32(on)]TJ /Span<>> BDC ( )Tj EMC (J. \017 \f\024\026\r\021. \r)Tj /Span<>> BDC ( )Tj EMC (2013 \020\024\007\031 \023\030\024\r\036\035\017 \n\027\024\020\024\006\036\ \027\021\030\024)Tj 0 Tw (-)Tj 0.255 Tw T* [(\r\024\036, )0.5(\023\030\024\f\023\036\022\021\017\r\027\024\036 )0.6(\017\f\f\035\036\007\024\r\026\027\017\036, )0.6(\r)]TJ /Span<>> BDC ( )Tj EMC 16.216 0 Td [(\022\024\021\024\030\024\036 )0.5(\002\t\035\024 )]TJ 0.233 Tw -16.216 -1.218 Td (\r\022\035\033\004\036\027\024 73 \023\026\006\017\036\027\021\026 \f\024\ \f\r\017\013\026\n\017 \023\030\016\n\024\005 \022\017\001\022\017, )Tj 0.208 Tw T* (\026)Tj /Span<>> BDC ( )Tj EMC (\017\f\022\035\033\004\036\027\017\036\n \030\036\022\021\024\r\026\020\017\ \027\026\035\034\027\t\b. \200)Tj /Span<>> BDC ( )Tj EMC (\022\026\004\036\f\021\r\036 \n\036)Tj 0 Tw (-)Tj 0.446 Tw T* (\021\024\007\026 \035\036\004\036\027\017\016 \023\030\017\n\036\027\016\ \035\f\016 \022\024\035\035\026\020\036\027\024\r\t\005 \017\n\023\035\026\ \027\021 )Tj 0.125 Tw T* [(Sur)-32(gisis AFP\256. \211)]TJ /Span<>> BDC ( )Tj EMC (72 \023\026\006\017\036\027\021\024\r \002\t\035\017 \021\030\026\027\f\f\ \235\017\027\022\021\036\030)Tj 0 Tw (-)Tj 0.283 Tw T* (\027\t\036 \f\r\017\013\017 \017)Tj /Span<>> BDC ( )Tj EMC (\031 \024\007\027\024\020\024 \023\026\006\017\036\027\021\026)Tj /Span<>> BDC ( )Tj EMC (\227 \220\022\f\021\030\026\f\235\017\027\022)Tj /Span<>> BDC (-)Tj EMC 0.169 Tw T* (\021\036\030\027\t\005 \f\r\017\013. \200)Tj /Span<>> BDC ( )Tj EMC (53)Tj /Span<>> BDC ( )Tj EMC (\f\035\031\004\026\016\b \f\r\017\013\017 \002\t\035\017 \023\036\030\r\017\ \004\027\t)Tj 0 Tw (-)Tj 0.268 Tw T* (\n\017, \031)Tj /Span<>> BDC ( )Tj EMC (20)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \027\024\f\017\035\017 \030\036\006\017\ \007\017\r\027\t\005 \b\026\030\026\022\021\036\030. )Tj 0.203 Tw T* (\224\030\036\007\027\017\005 \023\036\030\017\024\007 \027\026\002\035\033\ \007\036\027\017\016 \f\024\f\021\026\r\017\035 15 \n\036\f\016\006\036\r\ . )Tj -0.03 Tw T* (\215\024\035\027\024\036 \026\032\017\r\035\036\027\017\036 \f\r\017\013\ \036\005 \007\024\f\021\017\020\027\031\021\024 \031)Tj /Span<>> BDC ( )Tj EMC (38,0% \023\026\006\017)Tj 0 Tw (-)Tj -0.025 Tw T* [(\036\027\021\024\r )0.5(\(28 \017)]TJ /Span<>> BDC ( )Tj EMC 5.27 0 Td [(73\). )0.5(\224\030\036\007\017 \023\026\006\017\036\027\021\024\r )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC 9.704 0 Td [(\023\036\030\r\017\004\027\t\n\017 )0.5(\f\r\017)]TJ 0 Tw (-)Tj 0.119 Tw -14.974 -1.218 Td (\013\026\n\017 \r\t\007\024\030\024\r\035\036\027\017\036 \027\026\002\035\ \033\007\026\035\024\f\034 \031)Tj /Span<>> BDC ( )Tj EMC (20/53 \(38,0%\), )Tj 0.157 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\030\036\006\017\007\017\r\027\t\n\017)Tj /Span<>> BDC ( )Tj EMC (\227 \031)Tj /Span<>> BDC ( )Tj EMC (8/20 \(40,0%\). \210\021\021\024\030\032\036\027\017\036 \017\n)Tj 0 Tw (-)Tj 0.146 Tw T* (\023\035\026\027\021\026 \026\030\036\020\017\f\021\030\017\030\024\r\026\ \027\024 \r)Tj /Span<>> BDC ( )Tj EMC (9,0% \f\035\031\004\026\036\r \(7 \017)Tj /Span<>> BDC ( )Tj EMC (73\). )Tj 0.156 Tw T* (\200)Tj /Span<>> BDC ( )Tj EMC (\023\024\f\035\036\024\023\036\030\026\006\017\024\027\027\024\n \023\036\ \030\017\024\007\036 \026\002\f\006\036\f\f\t \030\026\r\017\035\017\f\034\ )Tj 0.166 Tw T* (\031)Tj /Span<>> BDC ( )Tj EMC (5,0% \023\026\006\017\036\027\021\024\r \(4 \017)Tj /Span<>> BDC ( )Tj EMC (73\). \202\r\021\024\030\t \007\036\035\026\033\021 \r\t\r\024\007, )Tj 0 Tw T* (\004\021\024 \017\f\023\024\035\034\024\r\026\027\017\036 \022\024\035\035\ \026\020\036\027\024\r\024\020\024 \017\n\023\035\026\027\021\026 \016\r\ \035\016\036\021\f\016 )Tj 0.048 Tw T* (\002\036\024\023\026\f\027\t\n \017)Tj /Span<>> BDC ( )Tj EMC (\007\024\f\021\026\021\024\004\027\024 \220\235\235\036\022\021\017\r\027\ \t\n \n\036\021\024\007\024\n \035\036)Tj 0 Tw (-)Tj 0.022 Tw T* (\004\036\027\017\016 \f\035\024\032\027\t\b \f\r\017\013\036\005 \023\030\ \016\n\024\005 \022\017\001\022\017, \023\024\r\024\035\016\033\013\017\ \n )Tj 0 Tw T* (\f\024\b\030\026\027\017\021\034 \235\031\027\022\006\017\033 \007\036\030\ \032\026\027\017\016)Tj /Span<>> BDC ( )Tj EMC ([25].)Tj 0.139 Tw T* [(S)15(t)15(amos)]TJ /Span<>> BDC ( )Tj EMC 3.23 0 Td [(M. )0.5(\017 \f\024\026\r\021. )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 5.991 0 Td [(2015 \020. )0.5(\023\030\024\r\036\035\017 )0.5(\n\027\024\020\024\006\036\027\021\030\024)]TJ 0 Tw (-)Tj 0.323 Tw -9.221 -1.218 Td (\r\024\036 \023\030\024\f\023\036\022\021\017\r\027\024\036 \017\f\f\035\ \036\007\024\r\026\027\017\036, \006\036\035\034\033 \022\024\021\024\030\ \024\020\024 )Tj 0.508 Tw T* (\002\t\035\024 \017\031\004\017\021\034 \220\235\235\036\022\021\017\r\027\ \024\f\021\034 \022\024\035\035\026\020\036\027\024\r\024\020\024 \017\n\ )Tj 0 Tw (-)Tj 0.088 Tw T* [(\023\035\026\027\021\026 Gor)-24(e\256 Bio-A\256 F)-19(istul)-16(a Pl)35(ug \r)]TJ /Span<>> BDC ( )Tj EMC (\035\036\004\036\027\017\017 \f\035\024\032\027\t\b )Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0 Tw 9 0 0 9 42.5197 730.483 Tm (\020\004\206\f\t\204\004 2.)Tj 0 0 0 1 k /GS1 gs /T1_3 1 Tf ( \212\037\033\037\021\035\016\033\022\024\035\022\021\037 \022\024\024\027\ \016\b\034\036\037\020\022\004 \036\034\001\016\b\001\022\002 \036)Tj /Span<>> BDC ( )Tj EMC [(\034\025\031\034\033 \027\022\035\016\033\037)0.5(\035\023\033\032)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf -0.027 Tc 0.027 Tw 0 -1.2 TD [(T)0.5(a)-35.3(b)-40.7(l)-38.7(e)-27( 2)-34.3(.)]TJ 0 0 0 1 k /GS1 gs /T1_3 1 Tf 0 Tc 0 Tw 3.334 0 Td [( C)-1.1(ha)-4.2(r)3.3(a)-9.1(c)-32.4(t)-1.6(e)-6(r)-39(i)6.6(s)-14.8(t)-29.1(i)-1.8(c)-26.7(s o)4.1(f)]TJ /Span<>> BDC ( )Tj EMC [(t)-10.6(h)-2.4(e s)-14.8(t)-1.1(u)-5.9(d)-2.9(i)-1.4(e)-22(s i)3.9(n)-2.9(c)-1.1(lu)-5.9(d)-5.3(e)-12.8(d i)3.9(n r)-2(e)-8.2(v)-32.5(i)-1.4(e)-7.9(w o)4(f)]TJ /Span<>> BDC ( )Tj EMC [(t)-10.6(h)-2.4(e li)-3.3(t)-1.6(e)-6(r)3.3(a)-9.2(t)-1.1(u)1.6(r)-2(e)]TJ ET 0 0 0 1 K 0.5 w /GS2 gs q 1 0 0 1 42.5197 715.181 cm 0 0 m 39.935 0 l S Q q 1 0 0 1 42.7697 665.5618 cm 0 0 m 0 49.369 l S Q q 1 0 0 1 82.4547 715.181 cm 0 0 m 36.85 0 l S Q q 1 0 0 1 82.4547 665.5618 cm 0 0 m 0 49.369 l S Q q 1 0 0 1 119.3051 715.181 cm 0 0 m 65.197 0 l S Q q 1 0 0 1 119.3051 665.5618 cm 0 0 m 0 49.369 l S Q q 1 0 0 1 184.502 715.181 cm 0 0 m 22.677 0 l S Q q 1 0 0 1 184.502 665.5618 cm 0 0 m 0 49.369 l S Q q 1 0 0 1 207.1791 715.181 cm 0 0 m 70.866 0 l S Q q 1 0 0 1 207.1791 665.5618 cm 0 0 m 0 49.369 l S Q q 1 0 0 1 278.0453 715.181 cm 0 0 m 36.85 0 l S Q q 1 0 0 1 278.0453 665.5618 cm 0 0 m 0 49.369 l S Q q 1 0 0 1 314.8957 715.181 cm 0 0 m 36.85 0 l S Q q 1 0 0 1 314.8957 665.5618 cm 0 0 m 0 49.369 l S Q q 1 0 0 1 351.7461 715.181 cm 0 0 m 68.031 0 l S Q q 1 0 0 1 351.7461 665.5618 cm 0 0 m 0 49.369 l S Q q 1 0 0 1 419.7776 715.181 cm 0 0 m 76.785 0 l S Q q 1 0 0 1 419.7776 665.5618 cm 0 0 m 0 49.369 l S Q q 1 0 0 1 496.313 665.5618 cm 0 0 m 0 49.369 l S Q q 1 0 0 1 42.5197 665.3118 cm 0 0 m 39.935 0 l S Q q 1 0 0 1 42.7697 634.9005 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 82.4547 665.3118 cm 0 0 m 36.85 0 l S Q q 1 0 0 1 82.4547 634.9005 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 119.3051 665.3118 cm 0 0 m 65.197 0 l S Q q 1 0 0 1 119.3051 634.9005 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 184.502 665.3118 cm 0 0 m 22.677 0 l S Q q 1 0 0 1 184.502 634.9005 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 207.1791 665.3118 cm 0 0 m 70.866 0 l S Q q 1 0 0 1 207.1791 634.9005 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 278.0453 665.3118 cm 0 0 m 36.85 0 l S Q q 1 0 0 1 278.0453 634.9005 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 314.8957 665.3118 cm 0 0 m 36.85 0 l S Q q 1 0 0 1 314.8957 634.9005 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 351.7461 665.3118 cm 0 0 m 68.031 0 l S Q q 1 0 0 1 351.7461 634.9005 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 419.7776 665.3118 cm 0 0 m 76.785 0 l S Q q 1 0 0 1 419.7776 634.9005 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 496.313 634.9005 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 42.5197 634.6505 cm 0 0 m 39.935 0 l S Q q 1 0 0 1 42.7697 604.2392 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 82.4547 634.6505 cm 0 0 m 36.85 0 l S Q q 1 0 0 1 82.4547 604.2392 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 119.3051 634.6505 cm 0 0 m 65.197 0 l S Q q 1 0 0 1 119.3051 604.2392 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 184.502 634.6505 cm 0 0 m 22.677 0 l S Q q 1 0 0 1 184.502 604.2392 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 207.1791 634.6505 cm 0 0 m 70.866 0 l S Q q 1 0 0 1 207.1791 604.2392 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 278.0453 634.6505 cm 0 0 m 36.85 0 l S Q q 1 0 0 1 278.0453 604.2392 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 314.8957 634.6505 cm 0 0 m 36.85 0 l S Q q 1 0 0 1 314.8957 604.2392 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 351.7461 634.6505 cm 0 0 m 68.031 0 l S Q q 1 0 0 1 351.7461 604.2392 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 419.7776 634.6505 cm 0 0 m 76.785 0 l S Q q 1 0 0 1 419.7776 604.2392 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 496.313 604.2392 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 42.5197 603.9892 cm 0 0 m 39.935 0 l S Q q 1 0 0 1 42.7697 582.9279 cm 0 0 m 0 20.811 l S Q q 1 0 0 1 82.4547 603.9892 cm 0 0 m 36.85 0 l S Q q 1 0 0 1 82.4547 582.9279 cm 0 0 m 0 20.811 l S Q q 1 0 0 1 119.3051 603.9892 cm 0 0 m 65.197 0 l S Q q 1 0 0 1 119.3051 582.9279 cm 0 0 m 0 20.811 l S Q q 1 0 0 1 184.502 603.9892 cm 0 0 m 22.677 0 l S Q q 1 0 0 1 184.502 582.9279 cm 0 0 m 0 20.811 l S Q q 1 0 0 1 207.1791 603.9892 cm 0 0 m 70.866 0 l S Q q 1 0 0 1 207.1791 582.9279 cm 0 0 m 0 20.811 l S Q q 1 0 0 1 278.0453 603.9892 cm 0 0 m 36.85 0 l S Q q 1 0 0 1 278.0453 582.9279 cm 0 0 m 0 20.811 l S Q q 1 0 0 1 314.8957 603.9892 cm 0 0 m 36.85 0 l S Q q 1 0 0 1 314.8957 582.9279 cm 0 0 m 0 20.811 l S Q q 1 0 0 1 351.7461 603.9892 cm 0 0 m 68.031 0 l S Q q 1 0 0 1 351.7461 583.1779 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 419.7776 603.9892 cm 0 0 m 76.785 0 l S Q q 1 0 0 1 419.7776 583.1779 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 496.313 583.1779 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 42.7697 571.7166 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 82.4547 571.7166 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 119.3051 571.7166 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 184.502 571.7166 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 207.1791 571.7166 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 278.0453 571.7166 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 314.8957 571.7166 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 351.4961 582.9279 cm 0 0 m 68.281 0 l S Q q 1 0 0 1 351.7461 571.7166 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 419.7776 582.9279 cm 0 0 m 76.785 0 l S Q q 1 0 0 1 419.7776 571.7166 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 571.7166 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 571.4666 cm 0 0 m 39.935 0 l S Q q 1 0 0 1 42.7697 550.6553 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 82.4547 571.4666 cm 0 0 m 36.85 0 l S Q q 1 0 0 1 82.4547 550.6553 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 119.3051 571.4666 cm 0 0 m 65.197 0 l S Q q 1 0 0 1 119.3051 550.6553 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 184.502 571.4666 cm 0 0 m 22.677 0 l S Q q 1 0 0 1 184.502 550.6553 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 207.1791 571.4666 cm 0 0 m 70.866 0 l S Q q 1 0 0 1 207.1791 550.6553 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 278.0453 571.4666 cm 0 0 m 36.85 0 l S Q q 1 0 0 1 278.0453 550.6553 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 314.8957 571.4666 cm 0 0 m 36.85 0 l S Q q 1 0 0 1 314.8957 550.6553 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 351.7461 571.4666 cm 0 0 m 68.031 0 l S Q q 1 0 0 1 351.7461 550.6553 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 419.7776 571.4666 cm 0 0 m 76.785 0 l S Q q 1 0 0 1 419.7776 550.6553 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 496.313 550.6553 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 42.5197 550.4053 cm 0 0 m 39.935 0 l S Q q 1 0 0 1 42.7697 529.5941 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 82.4547 550.4053 cm 0 0 m 36.85 0 l S Q q 1 0 0 1 82.4547 529.5941 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 119.3051 550.4053 cm 0 0 m 65.197 0 l S Q q 1 0 0 1 119.3051 529.5941 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 184.502 550.4053 cm 0 0 m 22.677 0 l S Q q 1 0 0 1 184.502 529.5941 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 207.1791 550.4053 cm 0 0 m 70.866 0 l S Q q 1 0 0 1 207.1791 529.5941 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 278.0453 550.4053 cm 0 0 m 36.85 0 l S Q q 1 0 0 1 278.0453 529.5941 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 314.8957 550.4053 cm 0 0 m 36.85 0 l S Q q 1 0 0 1 314.8957 529.5941 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 351.7461 550.4053 cm 0 0 m 68.031 0 l S Q q 1 0 0 1 351.7461 529.5941 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 419.7776 550.4053 cm 0 0 m 76.785 0 l S Q q 1 0 0 1 419.7776 529.5941 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 496.313 529.5941 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 42.5197 529.3441 cm 0 0 m 39.935 0 l S Q q 1 0 0 1 42.7697 508.2828 cm 0 0 m 0 20.811 l S Q q 1 0 0 1 82.4547 529.3441 cm 0 0 m 36.85 0 l S Q q 1 0 0 1 82.4547 508.2828 cm 0 0 m 0 20.811 l S Q q 1 0 0 1 119.3051 529.3441 cm 0 0 m 65.197 0 l S Q q 1 0 0 1 119.3051 508.2828 cm 0 0 m 0 20.811 l S Q q 1 0 0 1 184.502 529.3441 cm 0 0 m 22.677 0 l S Q q 1 0 0 1 184.502 508.2828 cm 0 0 m 0 20.811 l S Q q 1 0 0 1 207.1791 529.3441 cm 0 0 m 70.866 0 l S Q q 1 0 0 1 207.1791 508.5328 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 278.0453 529.3441 cm 0 0 m 36.85 0 l S Q q 1 0 0 1 278.0453 508.5328 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 314.8957 529.3441 cm 0 0 m 36.85 0 l S Q q 1 0 0 1 314.8957 508.2828 cm 0 0 m 0 20.811 l S Q q 1 0 0 1 351.7461 529.3441 cm 0 0 m 68.031 0 l S Q q 1 0 0 1 351.7461 508.2828 cm 0 0 m 0 20.811 l S Q q 1 0 0 1 419.7776 529.3441 cm 0 0 m 76.785 0 l S Q q 1 0 0 1 419.7776 508.2828 cm 0 0 m 0 20.811 l S Q q 1 0 0 1 496.313 508.2828 cm 0 0 m 0 20.811 l S Q q 1 0 0 1 42.7697 487.2215 cm 0 0 m 0 21.061 l S Q q 1 0 0 1 82.4547 487.2215 cm 0 0 m 0 21.061 l S Q q 1 0 0 1 119.3051 487.2215 cm 0 0 m 0 21.061 l S Q q 1 0 0 1 184.502 487.2215 cm 0 0 m 0 21.061 l S Q q 1 0 0 1 206.9291 508.2828 cm 0 0 m 71.366 0 l S Q q 1 0 0 1 207.1791 487.4715 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 278.0453 487.4715 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 314.8957 487.2215 cm 0 0 m 0 21.061 l S Q q 1 0 0 1 351.7461 487.2215 cm 0 0 m 0 21.061 l S Q q 1 0 0 1 419.7776 487.2215 cm 0 0 m 0 21.061 l S Q q 1 0 0 1 496.313 487.2215 cm 0 0 m 0 21.061 l S Q q 1 0 0 1 42.7697 475.7602 cm 0 0 m 0 11.461 l S Q q 1 0 0 1 82.4547 475.7602 cm 0 0 m 0 11.461 l S Q q 1 0 0 1 119.3051 475.7602 cm 0 0 m 0 11.461 l S Q q 1 0 0 1 184.502 475.7602 cm 0 0 m 0 11.461 l S Q q 1 0 0 1 206.9291 487.2215 cm 0 0 m 71.366 0 l S Q q 1 0 0 1 207.1791 476.0102 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 278.0453 476.0102 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 314.8957 475.7602 cm 0 0 m 0 11.461 l S Q q 1 0 0 1 351.7461 475.7602 cm 0 0 m 0 11.461 l S Q q 1 0 0 1 419.7776 475.7602 cm 0 0 m 0 11.461 l S Q q 1 0 0 1 496.313 475.7602 cm 0 0 m 0 11.461 l S Q q 1 0 0 1 42.7697 464.2989 cm 0 0 m 0 11.461 l S Q q 1 0 0 1 82.4547 464.2989 cm 0 0 m 0 11.461 l S Q q 1 0 0 1 119.3051 464.2989 cm 0 0 m 0 11.461 l S Q q 1 0 0 1 184.502 464.2989 cm 0 0 m 0 11.461 l S Q q 1 0 0 1 206.9291 475.7602 cm 0 0 m 71.366 0 l S Q q 1 0 0 1 207.1791 464.5489 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 278.0453 464.5489 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 314.8957 464.2989 cm 0 0 m 0 11.461 l S Q q 1 0 0 1 351.7461 464.2989 cm 0 0 m 0 11.461 l S Q q 1 0 0 1 419.7776 464.2989 cm 0 0 m 0 11.461 l S Q q 1 0 0 1 496.313 464.2989 cm 0 0 m 0 11.461 l S Q q 1 0 0 1 42.7697 453.0876 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 82.4547 453.0876 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 119.3051 453.0876 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 184.502 453.0876 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 206.9291 464.2989 cm 0 0 m 71.366 0 l S Q q 1 0 0 1 207.1791 453.0876 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 278.0453 453.0876 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 314.8957 453.0876 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 351.7461 453.0876 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 419.7776 453.0876 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 496.313 453.0876 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 42.5197 452.8376 cm 0 0 m 39.935 0 l S Q q 1 0 0 1 82.4547 452.8376 cm 0 0 m 36.85 0 l S Q q 1 0 0 1 119.3051 452.8376 cm 0 0 m 65.197 0 l S Q q 1 0 0 1 184.502 452.8376 cm 0 0 m 22.677 0 l S Q q 1 0 0 1 207.1791 452.8376 cm 0 0 m 70.866 0 l S Q q 1 0 0 1 278.0453 452.8376 cm 0 0 m 36.85 0 l S Q q 1 0 0 1 314.8957 452.8376 cm 0 0 m 36.85 0 l S Q q 1 0 0 1 351.7461 452.8376 cm 0 0 m 68.031 0 l S Q q 1 0 0 1 419.7776 452.8376 cm 0 0 m 76.785 0 l S Q BT /GS1 gs /T1_2 1 Tf 8 0 0 8 49.4683 687.3464 Tm (\032\003\002\006\013)Tj 4.959 0 Td (\255\003\006\004\b\004)Tj 4.524 0.6 Td (\020\t\212 \t\217\217\f\r\240\002\004)Tj (-)Tj 2.519 -1.2 Td (\b\t\235)Tj 5.53 0.6 Td (\027\002\240)Tj 3.356 0 Td (\215\r\003\002\240 \f\r\201\r\b\t\235)Tj 8.661 0.6 Td (\030\t\217\f\002 )Tj -0.575 -1.2 Td (\206\002\f\001\b\013\216)Tj 4.868 2.4 Td (\200\r\006\t\002\240 )Tj 0.057 -1.2 Td (\b\004\206\f\211)Tj (-)Tj 0.262 -1.2 Td (\240\r\b\t\235 )Tj 0.096 -1.2 Td (\(\214\r\217\))Tj 4.872 1.8 Td (\020\t\212\013 \217\t\227\r\005)Tj 10.274 2.4 Td (\030\004\217\003\002\003\004 )Tj -1.804 -1.2 Td (\013\213\240\002\006\002\f\r\b\t\235 )Tj -0.802 -1.2 Td (\212\006\t)Tj /Span<>> BDC ( )Tj EMC (\t\217\212\002\f\001\213\002\004\b\t\t )Tj 1.025 -1.2 Td (\220\002\f\f\004\n\r\b\002\002\n\002 )Tj 0.201 -1.2 Td (\t\214\212\f\004\b\003\004 \(%\))Tj /T1_1 1 Tf -48.508 -1.433 Td (Armstrong )Tj 0 -1.2 TD (D.N. et al.)Tj 5.991 1.2 Td (\224\221\202)Tj 3.828 0 Td (\203\036\030\026\027\007\024\n\017\017\030\024)Tj (-)Tj -0.177 -1.2 Td (\r\026\027\027\024\036; \215\030\024\f\023\036\022)Tj (-)Tj 2.22 -1.2 Td (\021\017\r\027\024\036)Tj 5.917 2.4 Td (2006)Tj 3.046 0 Td (\025\024\035\035\026\020\036\027\024\r\t\005 \017\n)Tj (-)Tj 2.636 -1.2 Td (\023\035\026\027\021)Tj 7.397 1.2 Td (15)Tj 4.606 0 Td (12)Tj 3.721 0 Td (\230\030\026\027\f\f\235\017\027\022\021\036\030)Tj (-)Tj 2.537 -1.2 Td (\027\t\036)Tj 8.99 1.2 Td (87,0)Tj -50.713 -3.833 Td (Ratto C. )Tj 0 -1.2 TD (et al.)Tj 5.442 1.2 Td (\236\021\026\035\017\016)Tj 4.376 0 Td (\203\036\030\026\027\007\024\n\017\017\030\024)Tj (-)Tj -0.177 -1.2 Td (\r\026\027\027\024\036; \215\030\024\f\023\036\022)Tj (-)Tj 2.22 -1.2 Td (\021\017\r\027\024\036)Tj 5.917 2.4 Td (2012)Tj 3.046 0 Td (\025\024\035\035\026\020\036\027\024\r\t\005 \017\n)Tj (-)Tj 2.636 -1.2 Td (\023\035\026\027\021)Tj 7.397 1.2 Td (11)Tj 4.606 0 Td (12)Tj 3.721 0 Td (\230\030\026\027\f\f\235\017\027\022\021\036\030)Tj (-)Tj 2.537 -1.2 Td (\027\t\036)Tj 8.99 1.2 Td (72,7)Tj -50.713 -3.833 Td (Ommer A. )Tj T* (et al.)Tj 5.514 1.2 Td (\206\036\030\n\026)Tj (-)Tj 0.645 -1.2 Td (\027\017\016)Tj 3.544 1.2 Td (\204\027\024\020\024\006\036\027\021\030\024\r\024\036; )Tj 0.424 -1.2 Td (\215\030\024\f\023\036\022\021\017\r\027\024\036)Tj 7.652 1.2 Td (2012)Tj 3.046 0 Td (\025\024\035\035\026\020\036\027\024\r\t\005 \017\n)Tj (-)Tj 2.636 -1.2 Td (\023\035\026\027\021)Tj 7.397 1.2 Td (40)Tj 4.606 0 Td (12)Tj 3.721 0 Td (\230\030\026\027\f\f\235\017\027\022\021\036\030)Tj (-)Tj 2.537 -1.2 Td (\027\t\036)Tj 8.99 1.2 Td (61,9)Tj -0.001 Tc 0.001 Tw -12.091 -2.633 Td (\225\022\f\021\030\026\235\017\027\022\021\036\030\027\t\036)Tj 0 Tc 0 Tw 12.091 0 Td (50,0)Tj -50.713 -1.433 Td (Cintron J. )Tj T* (et al.)Tj 5.991 1.2 Td (\224\221\202)Tj 3.712 0 Td (\204\027\024\020\024\006\036\027\021\030\024\r\024\036; )Tj 0.424 -1.2 Td (\215\030\024\f\023\036\022\021\017\r\027\024\036)Tj 7.652 1.2 Td (2013)Tj 3.046 0 Td (\025\024\035\035\026\020\036\027\024\r\t\005 \017\n)Tj (-)Tj 2.636 -1.2 Td (\023\035\026\027\021)Tj 7.397 1.2 Td (73)Tj 4.606 0 Td (15)Tj 3.721 0 Td (\230\030\026\027\f\f\235\017\027\022\021\036\030)Tj (-)Tj 2.537 -1.2 Td (\027\t\036)Tj 8.99 1.2 Td (38,0)Tj -50.713 -2.633 Td (Stamos M. )Tj T* (et)Tj /Span<>> BDC ( )Tj EMC (al.)Tj 5.991 1.2 Td (\224\221\202)Tj 3.712 0 Td (\204\027\024\020\024\006\036\027\021\030\024\r\024\036; )Tj 0.424 -1.2 Td (\215\030\024\f\023\036\022\021\017\r\027\024\036)Tj 7.652 1.2 Td (2015)Tj 3.046 0 Td (\025\024\035\035\026\020\036\027\024\r\t\005 \017\n)Tj (-)Tj 2.636 -1.2 Td (\023\035\026\027\021)Tj 7.397 1.2 Td (93)Tj 4.606 0 Td (12)Tj 3.721 0 Td (\230\030\026\027\f\f\235\017\027\022\021\036\030)Tj (-)Tj 2.537 -1.2 Td (\027\t\036)Tj 8.99 1.2 Td (41,0)Tj -50.713 -2.633 Td (Jayne D. )Tj T* (et al.)Tj 5.25 1.2 Td (\200\036\035\017\022\024)Tj (-)Tj -0.275 -1.2 Td (\002\030\017\021\026\027\017\016)Tj 4.998 1.2 Td (\215\030\024\f\023\036\022\021\017\r\027\024\036;)Tj -0.343 -1.2 Td (\217\026\027\007\024\n\017\017\030\024\r\026\027-)Tj 2.919 -1.2 Td (\027\024\036)Tj 5.231 2.4 Td (2021)Tj 3.046 0 Td (\025\024\035\035\026\020\036\027\024\r\t\005 \017\n)Tj (-)Tj 2.636 -1.2 Td (\023\035\026\027\021)Tj 7.147 1.2 Td (304)Tj 4.856 0 Td (12)Tj 3.721 0 Td (\230\030\026\027\f\f\235\017\027\022\021\036\030)Tj (-)Tj 2.537 -1.2 Td (\027\t\036)Tj 8.99 1.2 Td (54,0)Tj -30.044 -2.633 Td (\203\017\r\036\007\036\027\017\036 \f\035\017\017)Tj (-)Tj 1.167 -1.2 Td (\f\021\024\020\024 \035\024\f\022\031\021\026)Tj -0.98 -1.433 Td (\217\036\032\031\013\026\016 \035\017\020\026\021\031\030\026)Tj 0.17 -1.433 Td (\236\f\f\036\004\036\027\017\036 \f\r\017\013\026)Tj 2.748 -1.433 Td (LIFT)Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\206)10(\002\036\033 \035\030\032\003\033)30(\n)42(\032)-21(\230\033\241)]TJ 57.136 0 Td (REVIEW)Tj /T1_4 1 Tf 25 0 0 25 505.5395 56.0378 Tm (173)Tj ET endstream endobj 1171 0 obj <> endobj 1169 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.075 Tw 10 0 0 10 70.8661 724.8299 Tm (\023\036\030\036\007 \023\030\017\n\036\027\036\027\017\036\n \235\017\002\ \030\017\027\024\r\024\020\024 \022\035\036\016 \r\t\023\024\035\027\016\ \035\024\f\034 )Tj 0.158 Tw 0 -1.218 TD (\007\030\036\027\017\030\024\r\026\027\017\036 \f\r\017\013\036\r\024\020\ \024 \b\024\007\026. \215\026\006\017\036\027\021\t \027\026\002\035\033\ \007\026)Tj 0 Tw (-)Tj 0.131 Tw T* (\035\017\f\034 \r)Tj /Span<>> BDC ( )Tj EMC (\021\036\004\036\027\017\036 6 \n\036\f\016\006\036\r. \211\f\023\036\001\ \027\024\036 \035\036\004\036\027\017\036 \024\023\030\036)Tj 0 Tw (-)Tj 0.1 Tw T* (\007\036\035\016\035\024\f\034 \022\026\022 \024\021\f\031\021\f\021\r\017\ \036 \f\017\n\023\021\024\n\026\021\017\022\017, \b\026\030\026\022\021\036\ \030\027\024\005 )Tj 0.115 Tw T* (\007\035\016 \f\r\017\013\026 \023\030\016\n\024\005 \022\017\001\022\017\ . \217\036\031\035\034\021\026\021\t \017\f\f\035\036\007\024\r\026\027\ \017\016 )Tj 0.541 Tw T* (\023\024\022\026\026\035\017, \004\021\024 \004\026\f\021\024\021\026 \r\ \t\007\024\030\024\r\035\036\027\017\016 \f\024\f\021\026\r\017\035\026\ )Tj 0.034 Tw 0 -1.218 TD (57,1%)Tj /Span<>> BDC ( )Tj EMC (\227 \007\035\016 \r\t\f\024\022\017\b \f\r\017\013\036\005 \017)Tj /Span<>> BDC ( )Tj EMC (81,3%)Tj /Span<>> BDC ( )Tj EMC (\227 \007\035\016 \027\017\022\017\b )Tj 0.026 Tw 0 -1.218 TD [(\f\r\017\013\036\005. )0.6(\215\030\017)]TJ /Span<>> BDC ( )Tj EMC 5.525 0 Td [(\026\027\026\035\017\036 )0.6(\030\026\035\017\004\017\005 )0.5(\n\036\032\007\031 )0.5(\f\r\017\013\026\n\017 )0.6(\f)]TJ /Span<>> BDC ( )Tj EMC 15.238 0 Td (\024\007)Tj 0 Tw (-)Tj 0.191 Tw -20.763 -1.218 Td (\027\017\n \017)Tj /Span<>> BDC ( )Tj EMC (\027\036\f\022\024\035\034\022\017\n\017 \b\024\007\026\n\017 \004\026\f\ \021\024\021\026 \r\t\007\024\030\024\r\035\036\027\017\016 )Tj -0.024 Tw T* (\002\t\035\026 \f\035\036\007\031\033\013\036\005: \007\035\016 \f\r\017\ \013\036\005 \f)Tj /Span<>> BDC ( )Tj EMC (\024\007\027\017\n \b\024\007\024\n \f\024\f\021\026\r\017)Tj 0 Tw (-)Tj -0.02 Tw T* (\035\026 75,0% \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \r\t\f\024\022\017\b \f\r\017\013\036\005 \(6 \017\ )Tj /Span<>> BDC ( )Tj EMC (8 \023\026\006\017\036\027\021\024\r\) )Tj 0.045 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (75,0%)Tj /Span<>> BDC ( )Tj EMC (\227 \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \027\017\022\017\b \f\r\017\013\036\005 \(9 \017\ )Tj /Span<>> BDC ( )Tj EMC (12 \023\026\006\017\036\027)Tj 0 Tw (-)Tj 0.097 Tw 0 -1.218 TD (\021\024\r\). \200)Tj /Span<>> BDC ( )Tj EMC (\f\035\031\004\026\036 \f\r\017\013\036\005 \f)Tj /Span<>> BDC ( )Tj EMC (\027\036\f\022\024\035\034\022\017\n\017 \b\024\007\026\n\017 \004\026\f\ \021\024)Tj 0 Tw (-)Tj 0.076 Tw 0 -1.218 TD (\021\026 \r\t\007\024\030\024\r\035\036\027\017\016 \f\024\f\021\026\r\017\ \035\026 16,67%)Tj /Span<>> BDC ( )Tj EMC (\227 \007\035\016 \r\t\f\024\022\017\b )Tj -0.038 Tw 0 -1.218 TD (\f\r\017\013\036\005 \(1 \017)Tj /Span<>> BDC ( )Tj EMC (6 \023\026\006\017\036\027\021\024\r\) \017)Tj /Span<>> BDC ( )Tj EMC (50,0%)Tj /Span<>> BDC ( )Tj EMC (\227 \007\035\016 \027\017\022\017\b \f\r\017)Tj 0 Tw (-)Tj -0.023 Tw T* (\013\036\005 \(2 \017)Tj /Span<>> BDC ( )Tj EMC (4 \023\026\006\017\036\027\021\024\r\). \225\235\235\036\022\021\017\r\027\ \024\f\021\034 \n\036\021\024\007\026 \021\026\022\032\036 )Tj 0.095 Tw T* (\026\027\026\035\017\017\030\024\r\026\035\026\f\034 \r)Tj /Span<>> BDC ( )Tj EMC (\026\r\017\f\017\n\024\f\021\017 \024\021 \r\023\036\030\r\t\036 \r\024\ \027\017\022)Tj 0 Tw (-)Tj 0.176 Tw T* (\001\036\020\024 \017\035\017 \030\036\006\017\007\017\r\017\030\031\033\ \013\036\020\024 \f\r\017\013\026. \212\035\016 \023\036\030\r\017\004\027\ \t\b )Tj 0.098 Tw T* (\f\r\017\013\036\005 \004\026\f\021\024\021\026 \031\f\023\036\b\026 \f\024\ \f\021\026\r\017\035\026 70,0%)Tj /Span<>> BDC ( )Tj EMC (\227 \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 )Tj 0.027 Tw T* (\r\t\f\024\022\017\b \f\r\017\013\036\005 \017)Tj /Span<>> BDC ( )Tj EMC (75,0%)Tj /Span<>> BDC ( )Tj EMC (\227 \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \027\017\022\017\b \f\r\017\013\036\005. )Tj 0.308 Tw T* (\217\036\006\017\007\017\r\017\030\031\033\013\017\036 \f\r\017\013\017 \ \007\036\n\024\027\f\021\030\017\030\024\r\026\035\017 \020\024\030\026\ \007\024 )Tj 0.01 Tw T* (\n\036\027\034\001\031\033 \004\026\f\021\024\021\031 \031\f\023\036\b\026\ \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \r\t\f\024\022\017\b \f\r\017\013\036\005)Tj /Span<>> BDC ( )Tj EMC (\227 )Tj 0.275 Tw T* (14,29%, \021\024\020\007\026 \022\026\022 \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \027\017\022\017\b \f\r\017\013\036\005 \004\026\ \f\021\024)Tj 0 Tw (-)Tj 0.207 Tw T* (\021\026 \031\f\023\036\b\026 \024\f\021\026\r\026\035\026\f\034 \r\t\f\024\ \022\024\005 \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\f\021\026\r\035\016\035\026 75,0%. )Tj 0.204 Tw T* (\202\r\021\024\030\t \023\024\007\004\036\030\022\027\031\035\017, \004\021\ \024 \n\036\021\024\007 \024\022\026\026\035\f\016 \027\026\017\002\024\ \035\036\036 )Tj 0.089 Tw T* (\220\235\235\036\022\021\017\r\027\t\n \007\035\016 \027\017\022\017\b,\ \023\036\030\r\017\004\027\t\b \f\r\017\013\036\005, \026)Tj /Span<>> BDC ( )Tj EMC (\021\026\022)Tj 0 Tw (-)Tj 0.089 Tw T* (\032\036 \f\r\017\013\036\005 \f)Tj /Span<>> BDC ( )Tj EMC (\024\007\027\017\n \b\024\007\024\n. \224\035\024\032\027\026\016 \026\027\ \026\021\024\n\017\016 \r\t\f\024)Tj 0 Tw (-)Tj 0.031 Tw T* (\022\017\b, \030\036\006\017\007\017\r\017\030\031\033\013\017\b \017)Tj /Span<>> BDC ( )Tj EMC (\f\r\017\013\036\005 \f)Tj /Span<>> BDC ( )Tj EMC (\027\036\f\022\024\035\034\022\017\n\017 \b\024\007\026)Tj 0 Tw (-)Tj 0.098 Tw T* (\n\017 \024\020\030\026\027\017\004\017\r\026\035\026 \220\235\235\036\022\ \021\017\r\027\024\f\021\034 \235\017\002\030\017\027\024\r\024\020\024 \ \022\035\036\016, )Tj 0.086 Tw T* (\004\021\024 \f\r\016\026\027\024 \f)Tj /Span<>> BDC ( )Tj EMC (\021\030\031\007\027\024\f\021\016\n\017 \024\004\017\f\021\022\017 \r\f\ \036\b \b\024\007\024\r \017)Tj /Span<>> BDC ( )Tj EMC (\026)Tj 0 Tw (-)Tj -0.033 Tw T* (\023\024\035\027\036\027\017\016 \017\b \022\035\036\036\n. \215\030\017\ )Tj /Span<>> BDC ( )Tj EMC (\220\021\024\n \027\017 \031)Tj /Span<>> BDC ( )Tj EMC (\024\007\027\024\020\024 \023\026\006\017\036\027\021\026 \027\036 )Tj 0.086 Tw T* (\002\t\035\024 \r\t\016\r\035\036\027\024 \027\026\030\031\001\036\027\017\ \005 \235\031\027\022\006\017\017 \026\023\017\030\026\021\036\035\034\027\ \024\020\024 )Tj 0.11 Tw T* [(\026\023\023\026\030\026\021\026 )0.5(\023\030\016\n\024\005 )0.6(\022\017\001\022\017, )0.5(\004\021\024 )0.5(\023\024\007\021\r\036\030\032\007\026\036\021 )0.5(\002\036\024\023\026\f)]TJ 0 Tw (-)Tj 0.023 Tw T* (\027\024\f\021\034 \n\036\021\024\007\026. \202\r\021\024\030\t \f\004\017\ \021\026\033\021, \004\021\024 \235\017\002\030\017\027\024\r\t\005 \022\ \035\036\005 )Tj 0.357 Tw T* (\016\r\035\016\036\021\f\016 \023\030\036\007\023\024\004\021\017\021\036\ \035\034\027\t\n \n\036\021\024\007\024\n \035\036\004\036\027\017\016 \007\ \035\016 )Tj 0.091 Tw T* (\023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\027\017\022\017\n\017/\023\036\030\r\017\004\027\t\n\017 \f\r\017\013\026\ \n\017. \210\007\027\026\022\024 )Tj 0.212 Tw T* (\036\020\024 \017\f\023\024\035\034\024\r\026\027\017\036 \024\020\030\026\ \027\017\004\036\027\024 \r)Tj /Span<>> BDC ( )Tj EMC (\f\035\031\004\026\016\b \f\035\024\032\027\t\b, )Tj 0.238 Tw T* (\030\036\006\017\007\017\r\017\030\031\033\013\017\b \f\r\017\013\036\005\ \017)Tj /Span<>> BDC ( )Tj EMC (\f\r\017\013\036\005 \f)Tj /Span<>> BDC ( )Tj EMC (\027\036\f\022\024\035\034\022\017\n\017 )Tj 0.244 Tw T* [(\b\024\007\026\n\017, \004\021\024 \021\030\036\002\031\036\021 \007\024\ \023\024\035\027\017\021\036\035\034\027\t\b )0.5(\r\n\036\001\026\021\036\035\034\f\021\r )]TJ 0 Tw T* (\017\035\017 \026\035\034\021\036\030\027\026\021\017\r\027\t\b \023\024\ \007\b\024\007\024\r [36].)Tj 0.106 Tw T* [(Cest)15(ar)-32(o)]TJ /Span<>> BDC ( )Tj EMC (G. \017 \f\024\026\r\021. \r)Tj /Span<>> BDC ( )Tj EMC (2014 \020. \023\030\024\r\036\035\017 \017\f\f\035\036\007\024\r\026\027\ \017\036, )Tj 0.038 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\022\024\021\024\030\024\n \026\027\026\035\017\017\030\024\r\026\035\017\ \030\036\031\035\034\021\026\021\t \035\036\004\036\027\017\016 26)Tj /Span<>> BDC ( )Tj EMC (\023\026)Tj 0 Tw (-)Tj 0.155 Tw T* (\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\021\030\026\027\f\f\235\017\027\022\021\036\030\027\t\n\017 \017)Tj /Span<>> BDC ( )Tj EMC (\017\027\021\030\026\f\235\017\027\022\021\036\030\027\t)Tj 0 Tw (-)Tj 0.257 Tw T* (\n\017 \f\r\017\013\026\n\017 \023\030\016\n\024\005 \022\017\001\022\017\ , \022\024\021\024\030\t\n \002\t\035\024 \r\t\023\024\035)Tj 0 Tw (-)Tj 0.189 Tw T* (\027\036\027\024 \r\r\036\007\036\027\017\036 \235\017\002\030\017\027\024\ \r\024\020\024 \022\035\036\016 \r)Tj /Span<>> BDC ( )Tj EMC (\f\r\017\013\036\r\024\005 \b\024\007. )Tj -0.044 Tw T* (\215\030\017)Tj /Span<>> BDC ( )Tj EMC (\021\030\026\027\f\f\235\017\027\022\021\036\030\027\t\b \f\r\017\013\026\ \b \220\235\235\036\022\021\017\r\027\024\f\021\034 \f\024\f\021\026)Tj 0 Tw (-)Tj 0.055 Tw T* (\r\017\035\026 70,0%, \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\017\027\021\030\026\f\235\017\027\022\021\036\030\027\t\b)Tj /Span<>> BDC ( )Tj EMC (\227 66,7%. \210\002\013\026\016 )Tj 0.192 Tw T* [(\004\026\f\021\024\021\026 )0.5(\r\t\007\024\030\024\r\035\036\027\017\016 )0.6(\f\024\f\021\026\r\017\035\026 )0.6(69,2% )0.5(\026)]TJ /Span<>> BDC ( )Tj EMC 19.127 0 Td (\023\036\030\017\024\007 )Tj 0.078 Tw -19.127 -1.218 Td (\027\026\002\035\033\007\036\027\017\016 7 \n\036\f\016\006\036\r. \212\026\ \027\027\026\016 \n\036\021\024\007\017\022\026 \023\030\024\007\036\n\024\ \027)Tj 0 Tw (-)Tj 0.164 Tw T* [(\f\021\030\017\030\024\r\026\035\026 )0.5(\f\r\024\033 )0.6(\r\t\f\024\022\031\033 )0.5(\220\235\235\036\022\021\017\r\027\024\f\021\034 )0.6(\023\030\017)]TJ /Span<>> BDC ( )Tj EMC 20.255 0 Td (\023\030\024)Tj 0 Tw (-)Tj 0.155 Tw -20.255 -1.218 Td (\f\021\t\b \027\036\030\026\r\036\021\r\035\036\027\027\t\b \021\030\026\ \027\f\f\235\017\027\022\021\036\030\027\t\b \017)Tj /Span<>> BDC ( )Tj EMC (\017\027\021\036\030\f)Tj 0 Tw (-)Tj T* (\235\017\027\022\021\036\030\027\t\b \f\r\017\013\026\b [26].)Tj 0.683 Tw T* [(P)10(or)-22(t)-32(ill)-15.9(a)]TJ /Span<>> BDC ( )Tj EMC (F. \017 \f\024\026\r\021. \023\030\024\r\036\035\017 \030\026\027\007\024\ \n\017\017\030\024\r\026\027)Tj 0 Tw (-)Tj 0.505 Tw T* (\027\024\036 \017\f\f\035\036\007\024\r\026\027\017\036, \f\030\026\r\027\ \017\r\026\033\013\036\036 \220\235\235\036\022\021\017\r\027\024\f\021\034\ )Tj 0.17 Tw 23.244 64.543 Td (\026\031\021\024\035\024\020\017\004\027\024\005 \023\035\026\n\t \022\030\ \024\r\017, \002\024\020\026\021\024\005 \021\030\024\n\002\024\006\017\021\ \026\n\017 )Tj 0.063 Tw T* (\(PRP\), \017)Tj /Span<>> BDC ( )Tj EMC [(\235\017\002\030\017\027\024\r\024\020\024 \022\035\036\016 \(T)35(issucolDuo\256\) \r)]TJ /Span<>> BDC ( )Tj EMC (\035\036\004\036\027\017\017 )Tj 0.185 Tw T* (\f\035\024\032\027\t\b \022\030\017\023\021\024\020\035\026\027\007\031\035\ \016\030\027\t\b \f\r\017\013\036\005 \023\030\016\n\024\005 \022\017\001\ )Tj 0 Tw (-)Tj -0.003 Tw T* (\022\017. \200)Tj /Span<>> BDC ( )Tj EMC (\017\f\f\035\036\007\024\r\026\027\017\017 \031\004\026\f\021\r\024\r\026\ \035\017 66 \023\026\006\017\036\027\021\024\r, \017)Tj /Span<>> BDC ( )Tj EMC (\022\024)Tj 0 Tw (-)Tj 0.196 Tw T* (\021\024\030\t\b 32 \035\036\004\017\035\017\f\034 \f)Tj /Span<>> BDC ( )Tj EMC (\017\f\023\024\035\034\024\r\026\027\017\036\n PRP, \026)Tj /Span<>> BDC ( )Tj EMC (24)Tj /Span<>> BDC ( )Tj EMC (\227 )Tj 0.535 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\017\f\023\024\035\034\024\r\026\027\017\036\n \235\017\002\030\017\027\ \024\r\024\020\024 \022\035\036\016. \215\026\006\017\036\027\021\t )Tj 0.239 Tw 0 -1.218 TD (\027\026\002\035\033\007\026\035\017\f\034 \r)Tj /Span<>> BDC ( )Tj EMC (\021\036\004\036\027\017\036 12 \n\036\f\016\006\036\r. \230\017\023\t \f\ \r\017\013\036\005, )Tj 0.178 Tw 0 -1.218 TD (\r\022\035\033\004\036\027\027\t\b \r)Tj /Span<>> BDC ( )Tj EMC (\017\f\f\035\036\007\024\r\026\027\017\036: \021\030\026\027\f\f\235\017\ \027\022\021\036\030\027\t\036)Tj /Span<>> BDC ( )Tj EMC (\227 )Tj 0.263 Tw T* [(82,4%, )0.5(\017\027\021\030\026\f\235\017\027\022)]TJ /Span<>> BDC ( )Tj EMC 8.091 0 Td (\021\036\030\027\t\036)Tj /Span<>> BDC ( )Tj EMC 3.438 0 Td [(\227 )0.5(9,8% )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 4.948 0 Td (\220\022\f\021\030\026\f\235\017\027\022)Tj 0 Tw (-)Tj 0.155 Tw -16.478 -1.218 Td (\021\036\030\027\t\036 \f\r\017\013\017)Tj /Span<>> BDC ( )Tj EMC (\227 7,8%. \215\024\022\026\026\021\036\035\017 \023\024\035\027\024\020\ \024 \r\t\007\024)Tj 0 Tw (-)Tj 0.178 Tw T* (\030\024\r\035\036\027\017\016 \f\024\f\021\026\r\017\035\017 48,4% \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \f)Tj /Span<>> BDC ( )Tj EMC (\235\017\002\030\017\027\024\r\t\n )Tj 0.325 Tw T* (\022\035\036\036\n. \225\235\235\036\022\021\017\r\027\024\f\021\034 PRP\ \f\024\f\021\026\r\017\035\026: \021\030\026\027\f\f\235\017\027)Tj 0 Tw (-)Tj 0.054 Tw 0 -1.218 TD (\022\021\036\030\027\t\036)Tj /Span<>> BDC ( )Tj EMC (\227 82,4%, \017\027\021\030\026\f\235\017\027\022)Tj /Span<>> BDC ( )Tj EMC 12.862 0 Td (\021\036\030\027\t\036)Tj /Span<>> BDC ( )Tj EMC (\227 9,8% \017)Tj /Span<>> BDC ( )Tj EMC (\220\022\f)Tj 0 Tw (-)Tj 0.071 Tw -12.862 -1.218 Td (\021\030\026\f\235\017\027\022\021\036\030\027\t\036 \f\r\017\013\017)Tj /Span<>> BDC ( )Tj EMC (\227 7,8%. \200\f\036 \027\036\032\036\035\026\021\036\035\034\027\t\036\ )Tj 0.034 Tw 0 -1.218 TD [(\016\r\035\036\027\017\016 \002\t\035\017 \027\036\027\026\004\017\021\036\ \035\034\027\t\n\017, )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC (\027\017 \031)Tj /Span<>> BDC ( )Tj EMC (\024\007\027\024\020\024 \023\026\006\017)Tj 0 Tw (-)Tj 0.093 Tw T* (\036\027\021\026 \027\036 \027\026\002\035\033\007\026\035\024\f\034 \027\ \036\020\026\021\017\r\027\024\020\024 \r\035\017\016\027\017\016 \027\026\ )Tj /Span<>> BDC ( )Tj EMC (\235\031\027\022)Tj 0 Tw (-)Tj T* (\006\017\033 \007\036\030\032\026\027\017\016)Tj /Span<>> BDC ( )Tj EMC ([37].)Tj 0.48 Tw T* (\205\030\024\035\024\r)Tj /Span<>> BDC ( )Tj EMC (\224.\202. \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. \023\030\017\n\036\027\017\035\017 \024\021\036\004\036\ \f\021\r\036\027\027\t\005 )Tj 0.267 Tw T* (\235\017\002\030\017\027\024\r\t\005 \022\035\036\005 \f)Tj /Span<>> BDC ( )Tj EMC (\027\017\022\017\n \f\024\007\036\030\032\026\027\017\036\n \021\030\024\ \n\002\017)Tj 0 Tw (-)Tj 0.232 Tw T* [(\027\026 \(\025\030\017\024\235\017\021\). \216\017\030\031\030\020\017\004\ \036\f\022\026\016 \021\036\b\027\017\022\026 )0.5(\026\022\035\033\004\026\035\026\f\034 )]TJ 0.052 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\023\030\036\007\r\026\030\017\021\036\035\034\027\024\n \022\033\030\036\ \021\026\032\036 \f\r\017\013\036\r\024\020\024 \b\024\007\026, \007\026\ \035\036\036 )Tj 0.394 Tw T* (\023\024\f\035\036 \f\021\017\b\026\027\017\016 \220\022\f\f\031\007\026\ \021\017\r\027\024\020\024 \023\030\024\006\036\f\f\026, \r\021\024\030\t\ \n )Tj 0.034 Tw T* (\220\021\026\023\024\n, \r)Tj /Span<>> BDC ( )Tj EMC (\f\030\036\007\027\036\n, \027\026)Tj /Span<>> BDC ( )Tj EMC (5\2267)Tj /Span<>> BDC ( )Tj EMC (\f\031\021\022\017, \r\t\023\024\035\027\016\035\024\f\034 \r\r\036\007\036\ )Tj 0 Tw (-)Tj 0.034 Tw T* [(\027\017\036 )0.5(\235\017\002\030\017\027\024\r\024\020\024 )0.5(\022\035\036\016 \r)]TJ /Span<>> BDC ( )Tj EMC 10.476 0 Td [(\035\024\032\036 )0.5(\f\r\017\013\036\r\024\020\024 \b\024\007\026. )0.5(\200)]TJ /Span<>> BDC ( )Tj EMC 10.327 0 Td (\017\f)Tj 0 Tw (-)Tj 0.215 Tw -20.803 -1.218 Td (\f\035\036\007\024\r\026\027\017\036 \002\t\035\024 \r\022\035\033\004\036\ \027\024 28 \023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\017\027\021\030\026)Tj /Span<>> BDC (-)Tj EMC 0.777 Tw T* (\f\235\017\027\022\021\036\030\027\t\n\017 \017)Tj /Span<>> BDC ( )Tj EMC (\021\030\026\027\f\f\235\017\027\022\021\036\030\027\t\n\017 \f\r\017\013\ \026\n\017. )Tj 0.046 Tw T* (\224\030\024\022\017 \027\026\002\035\033\007\036\027\017\016 \f\024\f\021\ \026\r\017\035\017 \024\021 1 \027\036\007\036\035\017 \007\024)Tj /Span<>> BDC ( )Tj EMC (168)Tj /Span<>> BDC ( )Tj EMC (\027\036)Tj 0 Tw (-)Tj 0.32 Tw T* (\007\036\035\034. \200\t\007\024\030\024\r\035\036\027\017\036 \027\026\ \f\021\031\023\017\035\024 \r)Tj /Span<>> BDC ( )Tj EMC (89,3% \f\035\031\004\026\036\r. )Tj 0.202 Tw T* (\202\r\021\024\030\t \f\004\017\021\026\033\021, \004\021\024 \030\026\007\ \036\035\036\027\017\036 \027\026)Tj /Span<>> BDC ( )Tj EMC (\220\021\026\023\t \(\023\036\030\r\t\005 )Tj 0.049 Tw T* (\220\021\026\023)Tj /Span<>> BDC ( )Tj EMC 2.069 0 Td [(\227 )0.5(\023\030\036\007\r\026\030\017\021\036\035\034\027\026\016 )0.6(\024\002\030\026\002\024\021\022\026 )0.5(\f\r\017\013\036\r\024\020\024 )0.6(\b\024\007\026, )]TJ 0.226 Tw -2.069 -1.218 Td (\r\021\024\030\024\005 \220\021\026\023)Tj /Span<>> BDC ( )Tj EMC (\227 \r\r\036\007\036\027\017\036 \235\017\002\030\017\027\024\r\024\020\ \024 \022\035\036\016 \023\024\f\035\036 )Tj 0.049 Tw T* (\f\021\017\b\026\027\017\016 \026\022\021\017\r\027\024\020\024 \220\022\ \f\f\031\007\026\021\017\r\027\024\020\024 \023\030\024\006\036\f\f\026\)\ \023\024\r\t)Tj 0 Tw (-)Tj T* (\001\026\036\021 \220\235\235\036\022\021\017\r\027\024\f\021\034 \007\026\ \027\027\024\005 \n\036\021\024\007\017\022\017 [39,40].)Tj /T1_1 1 Tf 0 -2.436 TD (\021\002\f\f\004\n\r\b\002\013\005 \t\214\212\f\004\b\003)Tj /T1_0 1 Tf 0.012 Tw 0 -1.218 TD [(Ar)-16(mstr)-31.9(ong)]TJ /Span<>> BDC ( )Tj EMC (D.N. \017 \f\024\026\r\021. \r)Tj /Span<>> BDC ( )Tj EMC (2006)Tj /Span<>> BDC ( )Tj EMC (\020. \023\030\036\007\035\024\032\017\035\017 \f\023\024\f\024\002 )Tj 0.24 Tw T* (\035\036\004\036\027\017\016 \r\t\f\024\022\017\b \f\r\017\013\036\005 \023\ \030\016\n\024\005 \022\017\001\022\017 \f)Tj /Span<>> BDC ( )Tj EMC (\017\f\023\024\035\034)Tj 0 Tw (-)Tj 0.282 Tw T* [(\024\r\026\027\017\036\n )0.5(\022\024\035\035\026\020\036\027\024\r\024\020\024 )0.5(\017\n\023\035\026\027\021\026, )0.6(\017\020\024\021\024\r\035\036\027\027\024\020\024 )]TJ 0.102 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\035\017\024\235\017\035\017\017\030\024\r\026\027\027\024\020\024 \023\ \024\007\f\035\017\017\f\021\024\020\024 \f\035\024\016 \022\017\001\036\ \004)Tj 0 Tw (-)Tj 0.248 Tw T* [(\027\017\022\026 \f\r\017\027\034\017 \(T)47(he Sur)-31.9(gisis\256\) \(\217\017\f.)]TJ /Span<>> BDC ( )Tj EMC (2\). \215\024\f\035\036 \023\030\036\007)Tj 0 Tw (-)Tj 0.204 Tw T* (\r\026\030\017\021\036\035\034\027\024\020\024 \022\033\030\036\021\026\032\ \026 \017)Tj /Span<>> BDC ( )Tj EMC (\f\026\027\026\006\017\017 \f\r\017\013\036\r\024\020\024 \b\024\007\026\ )Tj 0.153 Tw T* (\023\036\030\036\022\017\f\034\033 \r\024\007\024\030\024\007\026 \022\024\ \035\035\026\020\036\027\024\r\t\005 \017\n\023\035\026\027\021\026\021 \ \031\f\021\026)Tj 0 Tw (-)Tj -0.044 Tw T* (\027\026\r\035\017\r\026\036\021\f\016 \023\024)Tj /Span<>> BDC ( )Tj EMC (\027\026\023\030\026\r\035\036\027\017\033 \024\021 \027\026\030\031\032\ \027\024\020\024 \024\021\r\036\030\f\021\017\016 )Tj -0.019 Tw T* (\f\r\017\013\026 \022)Tj /Span<>> BDC ( )Tj EMC (\r\027\031\021\030\036\027\027\036\n\031 \022\024\027\031\f\024\n \r\023\ \036\030\036\007. \003\026\021\036\n \036\020\024 \235\017\022)Tj 0 Tw (-)Tj -0.015 Tw T* (\f\017\030\031\033\021 \022)Tj /Span<>> BDC ( )Tj EMC (\f\035\017\017\f\021\024\n\031/\023\024\007\f\035\017\017\f\021\024\n\031\ \f\035\024\033 \017)Tj /Span<>> BDC ( )Tj EMC (\r\027\031\021\030\036\027)Tj 0 Tw (-)Tj 0.228 Tw T* (\027\036\n\031 \f\235\017\027\022\021\036\030\031 \f)Tj /Span<>> BDC ( )Tj EMC (\023\024\n\024\013\034\033 \r\024\f\034\n\017\024\002\030\026\027\024\020\ \024 \001\r\026. )Tj 0.067 Tw T* (\003\026)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\017\024\007 \027\026\002\035\033\007\036\027\017\016 \r)Tj /Span<>> BDC ( )Tj EMC (\021\036\004\036\027\017\036 12 \n\036\f\016\006\036\r \r\t\007\024)Tj 0 Tw (-)Tj T* (\030\024\r\035\036\027\017\036 \007\024\f\021\017\020\027\031\021\024 \031\ )Tj /Span<>> BDC ( )Tj EMC (87,0% \023\026\006\017\036\027\021\024\r [21].)Tj 0.12 Tw T* (\215\030\036\007\035\024\032\036\027\027\026\016 \n\036\021\024\007\017\022\ \026 \023\024\035\031\004\017\035\026 \001\017\030\024\022\024\036 \030\026\ \f\023\030\024)Tj 0 Tw (-)Tj 0.34 Tw T* [(\f\021\030\026\027\036\027\017\036 )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC 5.919 0 Td [(\026\022\021\017\r\027\024 )0.5(\023\030\017\n\036\027\016\035\026\f\034 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 10.855 0 Td (\022\035\017\027\017\004\036\f\022\024\005 )Tj 0.048 Tw -16.774 -1.218 Td (\023\030\026\022\021\017\022\036. \203\026)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\021\016\032\036\027\017\017 14 \035\036\021 \002\t\035\024 \ \024\023\031\002)Tj /Span<>> BDC ( )Tj EMC 18.208 0 Td (\035\017\022\024\r\026\027\024 )Tj 0.022 Tw -18.208 -1.218 Td [(\n\027\024\032\036\f\021\r\024 )0.5(\017\f\f\035\036\007\024\r\026\027\017\005, )0.5(\023\024\f\r\016\013\036\027\027\t\b )0.6(\023\030\017\n\036\027\036\027\017\033 )]TJ 0.189 Tw T* [(\022\024\035\035\026\020\036\027\024\r\024\020\024 )0.6(\017\n\023\035\026\027\021\026 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 11.686 0 Td [(\035\036\004\036\027\017\017 )0.6(\f\r\017\013\036\005 )0.5(\023\030\016\n\024\005 )]TJ 0 Tw -11.686 -1.218 Td (\022\017\001\022\017 \(\230\026\002\035.)Tj /Span<>> BDC ( )Tj EMC (2\).)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\206)10(\002\036\033 \035\030\032\003\033)30(\n)42(\032)-21(\230\033\241)]TJ 57.136 0 Td (REVIEW)Tj -57.136 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 2)69(4, \023\0224, 202)23(5)]TJ 43.013 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 2)69(4, \023\0224, 202)23(5)]TJ /T1_3 1 Tf 25 0 0 25 20.8276 56.0378 Tm (172)Tj ET endstream endobj 1168 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\034\201\021\024\016\215\016\215\021\016 \223\021\235\201\021\215\025\r\025\ \202)10(\025 \017)-10(\t\016\004 \021\022\235\021\025\222\t\001\b)-10(\026\021\f\016\b\017\021 \021\024\222\t\001\215\026)11(\025\r )]TJ 0 -1 TD [(\r\022\t\016\f\016\215\021\021 \b\r\021\232\016\207 \222\201\004\024\025\ \207 \017\021\020\017\021 \(\025\235\213\025\201\022\t\021\026)11(\016\201\001\026)-19.9(\200\201\220\))]TJ 32.168 1 Td [(Fibrin glue and bioplastic implants in tr)31(eatment of\022r)31(ectal f)-21(istulas \(r)31(e)11(vie)11(w\))]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0.344 Tw 10 0 0 10 42.5197 724.8299 Tm (\021\030\026\027\f\f\235\017\027\022\021\036\030\027\t\b \f\r\017\013\036\ \005 \023\030\016\n\024\005 \022\017\001\022\017 \022\030\017\023\021\024\ )Tj 0 Tw (-)Tj 0.418 Tw 0 -1.218 TD (\020\035\026\027\007\031\035\016\030\027\024\020\024 \023\030\024\017\f\b\ \024\032\007\036\027\017\016: \235\017\002\030\017\027\024\r\t\005 \022\035\ \036\005 )Tj -0.046 Tw T* [(\(T)35(isseal\256; Baxter, Inc, Mississauga, Ont)15.1(ar)-37(io\), \022\024\035\035\026\020\036\027\024)]TJ 0 Tw (-)Tj 0.096 Tw T* [(\r\t\005 \017\n\023\035\026\027\021 \(Sur)-32(gisis ES\256\), \031\f\021\026\027\024\r\022\026 \007\030\036\027\017\030\ \031\033\013\036\005 )]TJ 0.327 Tw T* [(\035\017\020\026\021\031\030\t \(Se)-12(t)17(ondr)-32.9(ain\) \017)]TJ /Span<>> BDC ( )Tj EMC (\027\017\r\036\007\036\027\017\036 \f\035\017\017\f\021\024-\n\t)Tj 0 Tw (-)Tj -0.013 Tw T* [(\001\036\004\027\024\020\024 )0.5(\035\024\f\022\031\021\026 \(A)15(d)-17(v)-15(ancement )0.5(\265)-16(ap cl)30(osur)-23.9(e\). \200)]TJ /Span<>> BDC ( )Tj EMC (\017\f\f\035\036)Tj 0 Tw (-)Tj -0.051 Tw 0 -1.218 TD (\007\024\r\026\027\017\036 \002\t\035\024 \r\022\035\033\004\036\027\024\ 232 \023\026\006\017\036\027\021\026, \023\036\030\017\024\007 \027\026\ \002\035\033)Tj 0 Tw (-)Tj 0.204 Tw 0 -1.218 TD (\007\036\027\017\016 \f\024\f\021\026\r\017\035 12 \027\036\007\036\035\034\ . \232\026\f\021\024\021\026 \r\t\007\024\030\024\r\035\036\027\017\016\ )Tj -0.003 Tw T* (\023\030\017)Tj /Span<>> BDC ( )Tj EMC (\023\030\017\n\036\027\036\027\017\017 \235\017\002\030\017\027\024\r\024\ \020\024 \022\035\036\016)Tj /Span<>> BDC ( )Tj EMC (\227 39,1%, \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\017\f)Tj 0 Tw (-)Tj 0.569 Tw T* [(\023\024\035\034\024\r\026\027\017\017 )0.5(\022\024\035\035\026\020\036\027\024\r\024\020\024 \017\n\023\035\026\027\ \021\026)]TJ /Span<>> BDC ( )Tj EMC 17.68 0 Td (\227 59,3%, )Tj 0.481 Tw -17.68 -1.218 Td (\023\030\017)Tj /Span<>> BDC ( )Tj EMC [(\027\017\r\036\007\036\027\017\036 )0.5(\f\035\017\017\f\021\024-\n\t\001\036\004\027\024\020\024 )0.5(\035\024\f\022\031\021\026)]TJ /Span<>> BDC ( )Tj EMC (\227 )Tj 0.155 Tw T* (60,4%. \202\r\021\024\030\t \023\030\017\001\035\017 \022)Tj /Span<>> BDC ( )Tj EMC (\r\t\r\024\007\031, \004\021\024 \022\024\035\035\026\020\036\027\024\r\t\ \005 )Tj 0.008 Tw 0 -1.218 TD (\017\n\023\035\026\027\021 \017)Tj /Span<>> BDC ( )Tj EMC (\235\017\002\030\017\027\024\r\t\005 \022\035\036\005 \002\036\024\023\026\ \f\027\t \r)Tj /Span<>> BDC ( )Tj EMC (\024\021\027\024\001\036\027\017\017 )Tj 0.355 Tw 0 -1.218 TD (\235\031\027\022\006\017\017 \026\023\017\030\026\021\036\035\034\027\024\ \020\024 \026\023\023\026\030\026\021\026 \023\030\016\n\024\005 \022\017\ \001\022\017, )Tj 0.175 Tw 0 -1.218 TD (\021\026\022\032\036 \024\027\017 \023\024\007\004\036\030\022\027\031\035\ \017 \027\036\024\002\b\024\007\017\n\024\f\021\034 \023\030\024\r\036\007\ \036\027\017\016 )Tj 0.017 Tw T* (\022\030\031\023\027\t\b \030\026\027\007\024\n\017\017\030\024\r\026\027\ \027\t\b \017\f\f\035\036\007\024\r\026\027\017\005 \007\035\016 \023\024\ \007)Tj 0 Tw (-)Tj T* (\021\r\036\030\032\007\036\027\017\016 \220\021\017\b \030\036\031\035\034\ \021\026\021\024\r [38].)Tj -0.051 Tw T* [(Al)56(t)17(omar)-23.9(e)]TJ /Span<>> BDC ( )Tj EMC (D. \017 \f\024\026\r\021. \r)Tj /Span<>> BDC ( )Tj EMC (2009 \020. \023\030\024\r\036\007\036\027 \026\027\026\035\017 \220\235\ \235\036\022)Tj 0 Tw (-)Tj 0.138 Tw T* [(\021\017\r\027\024\f\021\017 \023\030\017\n\036\027\036\027\017\016 \235\ \017\002\030\017\027\024\r\024\020\024 \022\035\036\016 \(T)35(issucol\256\) )]TJ 0.278 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\030\036\032\031\013\036\005 \035\017\020\026\021\031\030\t \023\030\017\ )Tj /Span<>> BDC ( )Tj EMC (\035\036\004\036\027\017\017 \021\030\026\027\f\f\235\017\027\022\021\036\ \030)Tj 0 Tw (-)Tj 0.087 Tw T* [(\027\t\b )0.5(\f\r\017\013\036\005 )0.5(\023\030\016\n\024\005 )0.5(\022\017\001\022\017. )0.6(\236\f\f\035\036\007\024\r\026\027\017\036 )0.5(\r\022\035\033\004\026\035\024 )]TJ 0.076 Tw T* (64)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\026, \022\024\021\024\030\t\036 \002\t\035\017\ \f\035\031\004\026\005\027\t\n \024\002\030\026\024\n \030\026)Tj 0 Tw (-)Tj 0.068 Tw T* (\007\036\035\036\027\t \027\026)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\t \035\036\004\036\027\017\016 \235\017\002\030\017\ \027\024\r\t\n \022\035\036\036\n \017)Tj /Span<>> BDC ( )Tj EMC (\035\017)Tj 0 Tw (-)Tj 0.06 Tw T* (\020\026\021\031\030\027\t\n \n\036\021\024\007\026\n. \205\017\002\030\017\ \027\024\r\t\005 \022\035\036\005 \017\f\023\024\035\034\024\r\026\035\f\ \016 )Tj 0.204 Tw T* (\022\026\022 \n\026\035\024\017\027\r\026\017\r\027\t\005 \n\036\021\024\ \007, \023\024\007\b\024\007\016\013\017\005 \007\035\016 \023\026\006\017\ )Tj 0 Tw (-)Tj 0.182 Tw T* [(\036\027\021\024\r )0.6(\f)]TJ /Span<>> BDC ( )Tj EMC 3.598 0 Td [(\r\t\f\024\022\017\n )0.5(\030\017\f\022\024\n )0.6(\030\026\r\017\021\017\016 )0.5(\027\036\007\024\f\021\026\021\024\004\027\024\f\021\017 )]TJ 0.059 Tw -3.598 -1.218 Td (\026\027\026\035\034\027\024\020\024 \f\235\017\027\022\021\036\030\026.\ \232\026\f\021\024\021\026 \r\t\007\024\030\024\r\035\036\027\017\016 \ \023\024\f\035\036 )Tj 0.31 Tw T* (\023\036\030\r\024\020\024 \023\030\017\n\036\027\036\027\017\016 \235\017\ \002\030\017\027\024\r\024\020\024 \022\035\036\016 \f\024\f\021\026\r\017\ \035\026 )Tj 0.263 Tw T* (39,0%, \026)Tj /Span<>> BDC ( )Tj EMC (\023\030\017 \023\024\r\021\024\030\027\024\n \r\r\036\007\036\027\017\017\ \007\024\f\021\017\020\026\035\026 50%. )Tj 0.175 Tw T* (\204\036\021\024\007 \b\026\030\026\022\021\036\030\017\024\r\026\035\f\ \016 \n\017\027\017\n\026\035\034\027\t\n \023\024\f\035\036\024\023\036\ \030\026)Tj 0 Tw (-)Tj 0.274 Tw T* (\006\017\024\027\027\t\n \002\024\035\036\r\t\n \f\017\027\007\030\024\n\ \024\n, \022\024\030\024\021\022\017\n \023\036\030\017\024\007\024\n )Tj 0.174 Tw T* (\020\024\f\023\017\021\026\035\017\026\006\017\017 \(\007\024 24 \004\026\ \f\024\r\) \017)Tj /Span<>> BDC ( )Tj EMC (\023\024\035\027\t\n \024\021\f\031\021\f\021\r\017)Tj 0 Tw (-)Tj 0.291 Tw T* (\036\n \r\035\017\016\027\017\016 \027\026)Tj /Span<>> BDC ( )Tj EMC (\235\031\027\022\006\017\033 \026\023\017\030\026\021\036\035\034\027\024\ \020\024 \026\023\023\026\030\026\021\026 )Tj 0.283 Tw T* (\023\030\016\n\024\005 \022\017\001\022\017. \210\007\027\026\022\024 \220\ \235\235\036\022\021\017\r\027\024\f\021\034 \002\t\035\026 \027\017\032\ \036 )Tj 0.132 Tw T* (\023\024)Tj /Span<>> BDC ( )Tj EMC (\f\030\026\r\027\036\027\017\033 \f)Tj /Span<>> BDC ( )Tj EMC (\b\017\030\031\030\020\017\004\036\f\022\017\n\017 \n\036\021\024\007\026\ \n\017. \212\035\016 \017\027)Tj 0 Tw (-)Tj 0.007 Tw T* [(\021\030\026\f\235\017\027\022\021\036\030\027\t\b )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC [(\027\017\022\017\b \021\030\026\027\f\f\235\017\027\022\021\036\030\027\ \t\b )0.5(\f\r\017\013\036\005 )]TJ 0.1 Tw T* (\004\026\f\021\024\021\026 \r\t\007\024\030\024\r\035\036\027\017\016 \f\ \024\f\021\026\r\017\035\026 70,0\22685,0%, \026)Tj /Span<>> BDC ( )Tj EMC (\007\035\016 )Tj 0.165 Tw T* (\f\035\024\032\027\t\b \021\030\026\027\f\f\235\017\027\022\021\036\030\027\ \t\b \f\r\017\013\036\005)Tj /Span<>> BDC ( )Tj EMC (\227 60,0\22670,0%. )Tj 0.135 Tw T* [(\217\036\032\031\013\026\016 \035\017\020\026\021\031\030\026, )0.5(\027\026\023\030\024\021\017\r, \024\002\036\f\023\036\004\017\r\026\035\ \026 \027\026\017\r\t\f)]TJ 0 Tw (-)Tj 0.046 Tw T* (\001\031\033 \004\026\f\021\024\021\031 \r\t\007\024\030\024\r\035\036\027\ \017\016)Tj /Span<>> BDC ( )Tj EMC (\227 87,5% \023\024\f\035\036 \023\036\030\r\024\020\024 )Tj 0.058 Tw T* [(\023\030\017\n\036\027\036\027\017\016. \212\035\016 \017\027\021\030\026\ \f\235\017\027\022\021\036\030\027\t\b )0.5(\f\r\017\013\036\005 \004\026\f\021\024\021\026 )]TJ 0.422 Tw T* (\r\t\007\024\030\024\r\035\036\027\017\016 \007\024\f\021\017\020\026\035\ \026 75,0\22690,0%, \007\035\016 \021\030\026\027\f)Tj 0 Tw (-)Tj 0.19 Tw T* (\f\235\017\027\022\021\036\030\027\t\b)Tj /Span<>> BDC ( )Tj EMC (\227 65,0\22680,0%, \026)Tj /Span<>> BDC ( )Tj EMC (\007\035\016 \f\035\024\032\027\t\b \021\030\026\027\f)Tj 0 Tw (-)Tj 0.629 Tw T* (\f\235\017\027\022\021\036\030\027\t\b \f\r\017\013\036\005 \220\235\235\ \036\022\021\017\r\027\024\f\021\034 \f\024\f\021\026\r\035\016\035\026 \ )Tj 0.162 Tw T* (50,0\22665,0%. \210\007\027\026\022\024 \220\021\024\021 \n\036\021\024\007\ \002\t\035 \f\r\016\026\027 \f)Tj /Span<>> BDC ( )Tj EMC (\023\024\r\t)Tj 0 Tw (-)Tj -0.023 Tw T* (\001\036\027\027\t\n \030\017\f\022\024\n \030\026\r\017\021\017\016 \027\ \036\007\024\f\021\026\021\024\004\027\024\f\021\017 \026\027\026\035\034\ \027\024\020\024 )Tj -0.012 Tw T* (\f\235\017\027\022\021\036\030\026 \(\f\030\036\007\027\017\005 \002\026\ \035\035 \023\024)Tj /Span<>> BDC ( )Tj EMC [(\001\022\026\035\036 W)22(e)-18(xner \031\r\036\035\017\004\017\035)]TJ 0 Tw (-)Tj 0.073 Tw T* (\f\016 \f)Tj /Span<>> BDC ( )Tj EMC (1,79 \007\024)Tj /Span<>> BDC ( )Tj EMC (5,1 \()Tj /T1_2 1 Tf 0 Tw (\033)Tj /T1_1 1 Tf 0.073 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,0017\)\), \024\f\024\002\036\027\027\024 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\035\036\004\036\027\017\017 )Tj 0.135 Tw T* (\f\035\024\032\027\t\b \f\r\017\013\036\005. \230\026\022\017\n \024\002\ \030\026\024\n, \017\f\f\035\036\007\024\r\026\027\017\036 \023\024)Tj 0 Tw (-)Tj 0.145 Tw T* (\022\026\026\035\024, \004\021\024 \235\017\002\030\017\027\024\r\t\005\ \022\035\036\005 \016\r\035\016\036\021\f\016 \002\036\024\023\026\f\027\ \t\n )Tj 0.096 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\n\026\035\024\017\027\r\026\017\r\027\t\n \n\036\021\024\007\024\n, \027\ \026\017\002\024\035\036\036 \024\023\030\026\r\007\026\027\027\t\n )Tj -0.04 Tw T* (\007\035\016 \023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\r\t\f\024\022\017\n \030\017\f\022\024\n \027\026\030\031\001\036\027\017\ \016 \235\031\027\022\006\017\017 )Tj -0.02 Tw T* (\026\023\017\030\026\021\036\035\034\027\024\020\024 \026\023\023\026\030\ \026\021\026 \023\030\016\n\024\005 \022\017\001\022\017. \202\r\021\024\ \030\t \f\004\017)Tj 0 Tw (-)Tj -0.036 Tw T* (\021\026\033\021, \004\021\024 \r\t\002\024\030 \n\036\021\024\007\026 \035\ \036\004\036\027\017\016 \007\024\035\032\036\027 \002\t\021\034 \024\f\027\ \024\r\026\027 )Tj 0.018 Tw 23.244 64.543 Td (\027\026)Tj /Span<>> BDC ( )Tj EMC (\022\035\017\027\017\004\036\f\022\017\b \024\f\024\002\036\027\027\024\f\ \021\016\b \f\r\017\013\026 \017)Tj /Span<>> BDC ( )Tj EMC (\235\031\027\022\006\017\024\027\026\035\034)Tj 0 Tw (-)Tj -0.045 Tw T* [(\027\024\n )0.5(\f\024\f\021\024\016\027\017\017 )0.6(\026\023\017\030\026\021\036\035\034\027\024\020\024 )0.6(\026\023\023\026\030\026\021\026 )0.5(\023\030\016\n\024\005 )0.6(\022\017\001)]TJ 0 Tw (-)Tj T* (\022\017 [35].)Tj 0.015 Tw T* (Haim N. \017 \f\024\026\r\021. \r)Tj /Span<>> BDC ( )Tj EMC (2011 \020. \023\030\024\r\036\035\017 \017\f\f\035\036\007\024\r\026\027\ \017\036, \027\026)Tj 0 Tw (-)Tj 0.06 Tw T* (\023\030\026\r\035\036\027\027\024\036 \027\026)Tj /Span<>> BDC ( )Tj EMC (\024\006\036\027\022\031 \007\024\035\020\024\f\030\024\004\027\024\005 \ \220\235\235\036\022\021\017\r\027\024\f\021\017 )Tj 0.185 Tw T* (\023\030\017\n\036\027\036\027\017\016 \235\017\002\030\017\027\024\r\024\ \020\024 \022\035\036\016 \r)Tj /Span<>> BDC ( )Tj EMC (\035\036\004\036\027\017\017 \f\035\024\032\027\t\b )Tj 0.359 Tw 0 -1.218 TD (\022\030\017\023\021\024\020\035\026\027\007\031\035\016\030\027\t\b \f\r\ \017\013\036\005. \236\f\f\035\036\007\024\r\026\027\017\036 \r\022\035\033\ )Tj 0 Tw (-)Tj 0.089 Tw 0 -1.218 TD (\004\026\035\024 \030\036\021\030\024\f\023\036\022\021\017\r\027\t\005 \ \026\027\026\035\017 \007\026\027\027\t\b \017)Tj /Span<>> BDC ( )Tj EMC (\021\036\035\036\235\024\027\027\024\036 )Tj 0.27 Tw T* (\026\027\022\036\021\017\030\024\r\026\027\017\036 \023\026\006\017\036\027\ \021\024\r, \022\024\021\024\030\t\036 \030\026\027\036\036 \031\004\026\ \f\021\r\024)Tj 0 Tw (-)Tj 0.465 Tw T* (\r\026\035\017 \r)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\f\023\036\022\021\017\r\027\024\n \017\f\f\035\036\007\024\r\ \026\027\017\017. \215\030\024\006\036\007\031\030\026 )Tj 0.425 Tw T* (\r\022\035\033\004\026\035\026 \023\030\036\007\r\026\030\017\021\036\035\ \034\027\024\036 \007\030\036\027\017\030\024\r\026\027\017\036 \f\r\017\ \013\036\005 )Tj 0.151 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\023\024\n\024\013\034\033 \035\017\020\026\021\031\030\t \(\023\030\017\ \027\036\024\002\b\024\007\017\n\024\f\021\017\), \n\036\b\026\027\017)Tj 0 Tw (-)Tj 0.021 Tw 0 -1.218 TD [(\004\036\f\022\031\033 )0.5(\024\002\030\026\002\024\021\022\031 \f\r\017\013\036\r\024\020\024 )0.5(\b\024\007\026 \f)]TJ /Span<>> BDC ( )Tj EMC [(\r\r\036\007\036\027\017\036\n )0.5(\022\035\036\016. )]TJ -0.028 Tw 0 -1.218 TD (\215\036\030\r\024\027\026\004\026\035\034\027\024 \r)Tj /Span<>> BDC ( )Tj EMC (\017\f\f\035\036\007\024\r\026\027\017\017 \031\004\026\f\021\r\024\r\026\ \035\024 60 \023\026\006\017)Tj 0 Tw (-)Tj 0.034 Tw 0 -1.218 TD (\036\027\021\024\r. \232\036\030\036 6 \n\036\f\016\006\036\r \031)Tj /Span<>> BDC ( )Tj EMC (32 \017)Tj /Span<>> BDC ( )Tj EMC (\027\017\b \027\026\002\035\033\007\026\035\024\f\034 \r\t)Tj 0 Tw (-)Tj 0.034 Tw T* (\007\024\030\024\r\035\036\027\017\036. \207\t\035\024 \023\030\024\f\035\ \036\032\036\027\024 23 \(72,0%\) \017 32)Tj /Span<>> BDC ( )Tj EMC (\023\026)Tj 0 Tw (-)Tj 0.017 Tw T* (\006\017\036\027\021\024\r. \224\030\036\007\027\017\005 \f\030\024\022 \ \027\026\002\035\033\007\036\027\017\016 \f\024\f\021\026\r\017\035 6,5)Tj /Span<>> BDC ( )Tj EMC (\035\036\021. )Tj 0.216 Tw T* (\217\036\031\035\034\021\026\021\t \017\f\f\035\036\007\024\r\026\027\017\ \016 \023\024\022\026\026\035\017, \004\021\024 \007\024\035\020\024\f\030\ \024\004)Tj 0 Tw (-)Tj 0.403 Tw T* (\027\026\016 \004\026\f\021\024\021\026 \r\t\007\024\030\024\r\035\036\027\ \017\016 \f\024\f\021\026\r\017\035\026 74,0% \(17 )Tj 0.029 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (23 \023\026\006\017\036\027\021\024\r\) \002\036 \030\036\006\017\007\017\ \r\026 \026\002\024\035\036\r\026\027\017\016. \210\007\027\026\022\024\ )Tj 0.049 Tw T* (\031)Tj /Span<>> BDC ( )Tj EMC (26,0% \023\026\006\017\036\027\021\024\r \(6 \017)Tj /Span<>> BDC ( )Tj EMC (23\) \027\026\002\035\033\007\026\035\017\f\034 \030\036\006\017\007\017\ \r\t, )Tj 0.106 Tw T* (\023\030\017\004\201\n \031)Tj /Span<>> BDC ( )Tj EMC (\004\036\021\t\030\201\b \017)Tj /Span<>> BDC ( )Tj EMC (\027\017\b \023\024\021\030\036\002\024\r\026\035\024\f\034 \017\035\017\ \r\f\022\030\t)Tj 0 Tw (-)Tj -0.007 Tw T* (\021\017\036 \024\f\021\030\024\020\024 \023\026\030\026\023\030\024\022\ \021\017\021\026, \017\035\017 \b\017\030\031\030\020\017\004\036\f\022\024\ \036 \r\n\036\001\026)Tj 0 Tw (-)Tj 0.117 Tw T* (\021\036\035\034\f\021\r\024 \023\024)Tj /Span<>> BDC ( )Tj EMC (\023\024\r\024\007\031 \030\036\006\017\007\017\r\026 \026\002\024\035\036\ \r\026\027\017\016. \224\030\036\007\027\036\036 )Tj -0.003 Tw T* (\r\030\036\n\016 \007\024)Tj /Span<>> BDC ( )Tj EMC (\030\036\006\017\007\017\r\026 \f\024\f\021\026\r\017\035\024 4,1 \020\024\ \007\026 \(\024\021)Tj /Span<>> BDC ( )Tj EMC (10 \n\036\f\016\006\036\r )Tj 0.028 Tw T* (\007\024)Tj /Span<>> BDC ( )Tj EMC (6 \035\036\021\). \202\r\021\024\030\t \023\030\017\001\035\017 \022)Tj /Span<>> BDC ( )Tj EMC (\r\t\r\024\007\031, \004\021\024 \235\017\002\030\017\027\024\r\t\005 )Tj 0.12 Tw T* (\022\035\036\005 \016\r\035\016\036\021\f\016 \002\036\024\023\026\f\027\ \t\n \017)Tj /Span<>> BDC ( )Tj EMC (\220\235\235\036\022\021\017\r\027\t\n \n\036\021\024\007\024\n )Tj 0.15 Tw T* [(\035\036\004\036\027\017\016 \f\035\024\032\027\t\b \022\030\017\023\021\ \024\020\035\026\027\007\031\035\016\030\027\t\b )0.5(\f\r\017\013\036\005 \023\030\016)]TJ 0 Tw (-)Tj 0.251 Tw T* (\n\024\005 \022\017\001\022\017. \204\036\021\024\007 \024\021\035\017\004\ \026\036\021\f\016 \023\030\024\f\021\024\021\024\005 \023\030\017\n\036\ \027\036)Tj 0 Tw (-)Tj 0.179 Tw T* [(\027\017\016 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 2.842 0 Td [(\n\017\027\017\n\026\035\034\027\t\n )0.6(\030\017\f\022\024\n )0.5(\023\024\r\030\036\032\007\036\027\017\016 )0.6(\026\027\026\035\034\027\024)]TJ 0 Tw (-)Tj 0.217 Tw -2.842 -1.218 Td (\020\024 \f\235\017\027\022\021\036\030\026. \210\007\027\026\022\024 \004\ \026\f\021\024\021\026 \030\026\r\017\021\017\016 \030\036\006\017\007\017\ \r\024\r )Tj 0.477 Tw T* (\023\024\007\004\201\030\022\017\r\026\036\021 \027\036\024\002\b\024\007\ \017\n\024\f\021\034 \021\013\026\021\036\035\034\027\024\020\024 \024\021\ \002\024\030\026 )Tj 0.168 Tw T* (\023\026\006\017\036\027\021\024\r \007\035\016 \017\f\023\024\035\034\024\ \r\026\027\017\016 \n\036\021\024\007\026, \026)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\032\036 \r\024)Tj 0 Tw (-)Tj -0.015 Tw T* (\n\024\032\027\024\f\021\034 \023\024\r\021\024\030\027\t\b \r\n\036\001\ \026\021\036\035\034\f\021\r \r)Tj /Span<>> BDC ( )Tj EMC (\f\035\031\004\026\036 \027\036\031\007\026\004\017. )Tj 0.143 Tw T* (\230\026\022\017\n \024\002\030\026\024\n, \235\017\002\030\017\027\024\ \r\t\005 \022\035\036\005 \024\f\021\026\201\021\f\016 \023\030\036\007\023\ \024)Tj 0 Tw (-)Tj 0.059 Tw T* (\004\021\017\021\036\035\034\027\t\n \r\026\030\017\026\027\021\024\n \007\ \035\016 \023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\r\t\f\024\022\017\n \030\017)Tj 0 Tw (-)Tj -0.016 Tw T* (\f\022\024\n \027\026\030\031\001\036\027\017\016 \235\031\027\022\006\017\ \017 \007\036\030\032\026\027\017\016, \027\024 \021\030\036\002\031\036\ \021 \007\026\035\034)Tj 0 Tw (-)Tj 0.066 Tw T* (\027\036\005\001\036\020\024 \017\031\004\036\027\017\016 \007\035\016 \ \023\024\r\t\001\036\027\017\016 \036\020\024 \007\024\035\020\024\f\030\ \024\004\027\024\005 )Tj 0 Tw T* (\220\235\235\036\022\021\017\r\027\024\f\021\017 [38].)Tj -0.047 Tw T* [(Mishr)-33(a A. \017 \f\024\026\r\021. \r)]TJ /Span<>> BDC ( )Tj EMC (2013 \020. \023\030\024\r\036\035\017 \017\f\f\035\036\007\024\r\026\027\ \017\036, \027\026)Tj 0 Tw (-)Tj 0.114 Tw T* (\023\030\026\r\035\036\027\027\024\036 \027\026)Tj /Span<>> BDC ( )Tj EMC (\024\006\036\027\022\031 \220\235\235\036\022\021\017\r\027\024\f\021\017\ \235\017\002\030\017\027\024\r\024\020\024 )Tj 0.094 Tw T* (\022\035\036\016 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\035\036\004\036\027\017\017 \r\t\f\024\022\017\b \017)Tj /Span<>> BDC ( )Tj EMC (\027\017\022\017\b \f\r\017\013\036\005 \023\030\016\n\024\005 )Tj 0.268 Tw T* (\022\017\001\022\017. \236\f\f\035\036\007\024\r\026\027\017\036 \r\022\035\ \033\004\026\035\024 30 \023\026\006\017\036\027\021\024\r, \022\024)Tj 0 Tw (-)Tj 0.139 Tw T* (\021\024\030\t\036 \002\t\035\017 \030\026\007\036\035\036\027\t \027\026\ )Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\t \r)Tj /Span<>> BDC ( )Tj EMC (\026\r\017\f\017\n\024\f\021\017 \024\021 )Tj 0.012 Tw T* (\026\027\026\021\024\n\017\004\036\f\022\024\020\024 \021\017\023\026 \f\ \r\017\013\026 \017)Tj /Span<>> BDC ( )Tj EMC (\036\020\024 \030\026\f\023\024\035\024\032\036\027\017\016: \r\t)Tj 0 Tw (-)Tj 0.056 Tw T* (\f\024\022\017\036 \f\r\017\013\017 \(14 \023\026\006\017\036\027\021\024\ \r\) \017)Tj /Span<>> BDC ( )Tj EMC (\027\017\022\017\036 \f\r\017\013\017 \(16)Tj /Span<>> BDC ( )Tj EMC (\023\026)Tj 0 Tw (-)Tj -0.091 Tw T* (\006\017\036\027\021\024\r\). \200\t\f\024\022\017\036, \f\024\020\035\026\ \f\027\024 \024\023\017\f\026\027\017\033, \023\030\036\007\f\021\026\r\035\ \036\027\t )Tj -0.082 Tw T* (\021\030\026\027\f\f\235\017\027\022\021\036\030\027\t\n\017 \017)Tj /Span<>> BDC ( )Tj EMC (\220\022\f\021\030\026\f\235\017\027\022\021\036\030\027\t\n\017 \f\r\017\ \013\026\n\017, )Tj 0.124 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC 0.793 0 Td [(\030\026\f\023\024\035\024\032\036\027\017\036\n )0.6(\r\027\031\021\030\036\027\027\036\020\024 )0.5(\024\021\r\036\030\f\021\017\016 )0.6(\r\t\001\036 )0.5(\026\027\024)]TJ 0 Tw (-)Tj 0.042 Tw -0.793 -1.218 Td (\030\036\022\021\026\035\034\027\024\020\024 \022\024\035\034\006\026. \203\ \017\022\017\036, \f)Tj /Span<>> BDC ( )Tj EMC (\r\027\031\021\030\036\027\027\017\n \024\021\r\036\030\f\021\017)Tj 0 Tw (-)Tj 0.017 Tw T* (\036\n \027\017\032\036 \026\027\024\030\036\022\021\026\035\034\027\024\ \020\024 \022\024\035\034\006\026, \n\024\032\027\024 \022\035\026\f\f\017\ \235\017\006\017)Tj 0 Tw (-)Tj -0.054 Tw T* (\030\024\r\026\021\034 \022\026\022 \017\027\021\030\026\f\235\017\027\022\ \021\036\030\027\t\036 \017\035\017 \021\030\026\027\f\f\235\017\027\022\ \021\036\030\027\t\036 )Tj -0.012 Tw T* [(\f\r\017\013\017. )0.6(\205\017\002\030\017\027\024\r\t\005 )0.5(\022\035\036\005 )0.5(\r\r\024\007\017\035\f\016 )0.6(\023\024\f\035\036 )0.5(\021\013\026\021\036\035\034\027\024)]TJ 0 Tw (-)Tj 0.08 Tw T* (\020\024 \022\033\030\036\021\026\032\026 \f\r\017\013\036\r\024\020\024\ \b\024\007\026. \203\036\022\024\021\024\030\t\n \023\026\006\017\036\027\ \021\026\n )Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 0 Tw 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\206)10(\002\036\033 \035\030\032\003\033)30(\n)42(\032)-21(\230\033\241)]TJ 57.136 0 Td (REVIEW)Tj /T1_3 1 Tf 25 0 0 25 504.7145 56.0378 Tm (171)Tj ET endstream endobj 1158 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1159 0 obj <>/ExtGState<>/Font<>/ProcSet[/PDF/Text]/Properties<>/Shading<>/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1160 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1161 0 obj <>/Font<>/ProcSet[/PDF/Text/ImageB/ImageC]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1162 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1196 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 0 0 0 1 k /GS1 gs /T1_0 1 Tf 10 0 0 10 70.8661 347.3119 Tm (\203\t\206\006\t\b\002\013\005 \220\f\r\005)Tj /T1_1 1 Tf 0.14 Tw 0 -1.218 TD (\205\017\002\030\017\027\024\r\t\005 \022\035\036\005 \016\r\035\016\036\ \021\f\016 \023\036\030\r\t\n \002\017\024\n\026\021\036\030\017\026\035\ \024\n, )Tj 0.256 Tw T* (\022\024\021\024\030\t\005 \002\t\035 \023\030\017\n\036\027\036\027 \r)Tj /Span<>> BDC ( )Tj EMC (\035\036\004\036\027\017\017 \f\r\017\013\036\005 \023\030\016\n\024\005\ )Tj 0.16 Tw T* (\022\017\001\022\017, \f\024\f\021\024\016\013\017\005 \017)Tj /Span<>> BDC ( )Tj EMC (\235\017\002\030\017\027\024\020\036\027\026, \021\030\024\n\002\017\027\ \026 \017)Tj /Span<>> BDC ( )Tj EMC (\017\024)Tj 0 Tw (-)Tj 0.112 Tw T* (\027\024\r \022\026\035\034\006\017\016. \204\036\b\026\027\017\n \007\036\ \005\f\021\r\017\016 \235\017\002\030\017\027\024\r\024\020\024 \022\035\ \036\016 )Tj 0.054 Tw T* (\026\022\035\033\004\026\036\021\f\016 \r)Tj /Span<>> BDC ( )Tj EMC (\f\035\036\007\031\033\013\036\n, \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\030\026\f\013\036\023\035\036\027\017\017 \235\017\002\030\017)Tj 0 Tw (-)Tj 0.313 Tw T* (\027\024\020\036\027\026 \027\026)Tj /Span<>> BDC ( )Tj EMC (\n\024\027\024\n\036\030\t \235\017\002\030\017\027\026 \024\002\030\026\ \031\036\021\f\016 \235\017\002\030\017)Tj 0 Tw (-)Tj 0.216 Tw T* (\027\024\r\t\005 \f\020\031\f\021\024\022, \022\024\021\024\030\t\005 \f\ \021\026\002\017\035\017\017\030\031\036\021\f\016 \r)Tj /Span<>> BDC ( )Tj EMC (\023\030\017\f\031\021)Tj 0 Tw (-)Tj 0.001 Tw T* (\f\021\r\017\017 \017\024\027\024\r \022\026\035\034\006\017\016 \017)Tj /Span<>> BDC ( )Tj EMC (XIII \235\026\022\021\024\030\026 \f\r\036\030\021\t\r\026\036\n\024\f\021\ \017. )Tj 0.22 Tw T* (\205\017\002\030\017\027\024\r\t\005 \022\035\036\005 \f\021\017\n\031\035\ \017\030\031\036\021 \n\017\020\030\026\006\017\033 \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\035\017)Tj 0 Tw (-)Tj 0.201 Tw T* (\235\036\030\026\006\017\033 \235\017\002\030\024\002\035\026\f\021\024\r\ \017)Tj /Span<>> BDC ( )Tj EMC (\023\035\033\030\017\023\024\021\036\027\021\027\t\b \220\027\007\024\021\ \036)Tj 0 Tw (-)Tj 0.16 Tw T* [(\035\017\026\035\034\027\t\b )0.6(\022\035\036\021\024\022 )0.5(\023\026\006\017\036\027\021\026 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 13.012 0 Td [(\023\030\017\035\036\020\026\033\013\017\b )0.6(\021\022\026\027\036\005. )]TJ -0.044 Tw -13.012 -1.218 Td (\200)Tj /Span<>> BDC ( )Tj EMC 0.734 0 Td (\021\036\004\036\027\017\036 1\2262)Tj /Span<>> BDC ( )Tj EMC 5.213 0 Td [(\027\036\007\036\035\034 )0.5(\023\035\026\n\017\027 )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC 7.831 0 Td [(\024\022\030\031\032\026\033\013\017\b )0.6(\021\022\026\027\036\005 )]TJ 0.037 Tw -13.779 -1.218 Td [(\035\017\017\030\031\036\021 )0.6(\235\017\002\030\017\027\024\r\t\005 )0.5(\f\020\031\f\021\024\022, )0.6(\026\n\036\013\026\016 )0.5(\036\020\024 )0.5(\f\017\027\021\036\017)]TJ 0 Tw (-)Tj T* (\030\024\r\026\027\027\t\n \022\024\035\035\026\020\036\027\024\n [33].)Tj 0.177 Tw T* (\200\023\036\030\r\t\036 \r)Tj /Span<>> BDC ( )Tj EMC (\017\f\021\024\030\017\017 \235\017\002\030\017\027\024\r\t\005 \022\024\ \n\023\024\027\036\027\021 \023\030\017\n\036)Tj 0 Tw (-)Tj 0.192 Tw T* (\027\016\035\f\016 \r)Tj /Span<>> BDC ( )Tj EMC (\r\017\007\036 \235\017\002\030\017\027\024\r\024\020\024 \023\024\030\024\ \001\022\026 \036\013\036 \r)Tj /Span<>> BDC ( )Tj EMC (1909 \020. )Tj -0.014 Tw T* [(Ber)-32(gel)]TJ /Span<>> BDC ( )Tj EMC (S. [42]. \200)Tj /Span<>> BDC ( )Tj EMC (1918 \020\024\007\031 \023\024\016\r\017\035\026\f\034 \027\024\r\026\016\ \235\024\030\n\026)Tj /Span<>> BDC ( )Tj EMC (\227 )Tj -0.027 Tw T* (\235\017\002\030\017\027\024\r\t\036 \021\026\n\023\024\027\t, \022\024\021\ \024\030\t\036 \023\030\017\n\036\027\016\035\017\f\034 \r)Tj /Span<>> BDC ( )Tj EMC (\b\017\030\031\030)Tj 0 Tw (-)Tj 0.067 Tw T* [(\020\017\017 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 2.523 0 Td [(\021\030\026\r\n\026\021\024\035\024\020\017\017 )0.6(\007\035\016 )0.5(\022\031\023\017\030\024\r\026\027\017\016 )0.6(\022\030\024\r\024\021\036\004\036\027\017\005 )]TJ 0.024 Tw -2.523 -1.218 Td ([44]. \210\007\027\026\022\024 \024\002\035\026\f\021\034 \017\b \023\030\ \017\n\036\027\036\027\017\016 \024\020\030\026\027\017\004\017\r\026\035\ \026\f\034 )Tj 0.205 Tw T* [(\235\024\030\n\024\005 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 4.65 0 Td [(\030\026\n\036\030\026\n\017 )0.5(\021\026\n\023\024\027\024\r. )0.5(\200 )0.5(1944 )0.5(\020. )0.6(\r\t\b\024\007\016\021 )]TJ 0.011 Tw -4.65 -1.218 Td (\023\036\030\r\t\036 \030\026\002\024\021\t, \r)Tj /Span<>> BDC ( )Tj EMC (\022\024\021\024\030\t\b \024\023\017\f\026\027 \007\r\031\b\022\024\n\023\ \024\027\036\027\021\027\t\005 )Tj 0.036 Tw 23.244 26.792 Td (\235\017\002\030\017\027\024\r\t\005 \022\035\036\005, \017\f\023\024\035\ \034\031\036\n\t\005 \r)Tj /Span<>> BDC ( )Tj EMC (\023\035\026\f\021\017\004\036\f\022\024\005 \b\017)Tj 0 Tw (-)Tj 0.029 Tw T* (\030\031\030\020\017\017. \205\017\002\030\017\027\024\r\t\005 \022\035\036\ \005 \023\024\035\031\004\026\035\017 \017)Tj /Span<>> BDC ( )Tj EMC (\023\035\026\n\t \f\026\n\024)Tj 0 Tw (-)Tj T* (\020\024 \023\026\006\017\036\027\021\026 [17,43].)Tj 0.119 Tw T* (\200\023\036\030\r\t\036 \r)Tj /Span<>> BDC ( )Tj EMC (\035\036\004\036\027\017\017 \f\r\017\013\036\005 \023\030\016\n\024\005\ \022\017\001\022\017 \007\r\031\b\022\024\n)Tj 0 Tw (-)Tj 0.166 Tw T* [(\023\024\027\036\027\021\027\t\005 \235\017\002\030\017\027\024\r\t\005 \ \022\035\036\005 \023\030\017\n\036\027\017\035 Hjor)-22(tr)-22(up)]TJ /Span<>> BDC ( )Tj EMC (\202. )Tj 0.21 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC [(1991 \020. )0.5(\215\030\036\007\035\024\032\036\027\027\026\016 )0.5(\017\n )0.5(\n\036\021\024\007\017\022\026 \026\022\035\033\004\026\035\026\f\034 )]TJ 0.132 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\023\030\036\007\r\026\030\017\021\036\035\034\027\024\n \022\033\030\036\ \021\026\032\036 \f\r\017\013\036\r\024\020\024 \b\024\007\026 \f)Tj /Span<>> BDC ( )Tj EMC (\023\024)Tj 0 Tw (-)Tj 0.047 Tw T* (\f\035\036\007\031\033\013\017\n \r\r\036\007\036\027\017\036 \235\017\002\ \030\017\027\024\r\024\020\024 \022\035\036\016 \r)Tj /Span<>> BDC ( )Tj EMC (\035\024\032\036 \f\r\017)Tj 0 Tw (-)Tj 0.111 Tw T* (\013\036\r\024\020\024 \b\024\007\026. \224\030\024\022 \027\026\002\035\ \033\007\036\027\017\016 \f\024\f\021\026\r\017\035 26 \027\036\007\036\035\ \034. )Tj 0.396 Tw T* (\211)Tj /Span<>> BDC ( )Tj EMC (12/23 \(52%\) \023\026\006\017\036\027\021\024\r \026\032\017\r\035\036\ \027\017\036 \027\026\f\021\031\023\017\035\024 )Tj 0.378 Tw T* (\023\024\f\035\036 \023\036\030\r\024\020\024 \017\f\023\024\035\034\024\ \r\026\027\017\016 \235\017\002\030\017\027\024\r\024\020\024 \022\035\036\ \016. )Tj 0.093 Tw T* (\211)Tj /Span<>> BDC ( )Tj EMC (11/23 \(48%\) \023\026\006\017\036\027\021\024\r \r)Tj /Span<>> BDC ( )Tj EMC (\021\036\004\036\027\017\036 19 \n\036\f\016\006\036\r \002\t\035 )Tj 0.075 Tw T* (\r\t\016\r\035\036\027 \030\036\006\017\007\017\r \026\002\024\035\036\r\ \026\027\017\016, \031)Tj /Span<>> BDC ( )Tj EMC (5 \(45%\) \017)Tj /Span<>> BDC ( )Tj EMC (\027\017\b \023\024)Tj 0 Tw (-)Tj 0.205 Tw T* (\f\035\036 \023\024\r\021\024\030\027\024\020\024 \023\030\017\n\036\027\ \036\027\017\016 \235\017\002\030\017\027\024\r\024\020\024 \022\035\036\ \016 \027\026)Tj 0 Tw (-)Tj 0.157 Tw T* (\f\021\031\023\017\035\024 \r\t\007\024\030\024\r\035\036\027\017\036. \ \202\035\035\036\030\020\017\004\036\f\022\017\b \030\036\026\022\006\017\ \005 \027\036 )Tj 0 Tw T* (\024\021\n\036\004\026\035\024\f\034 [16].)Tj 0.099 Tw T* (\224 2009 \020\024\007\026 \023\030\017\n\036\027\036\027\017\036 \007\026\ \027\027\024\005 \n\036\021\024\007\017\022\017 \023\024\035\031\004\017\ \035\024 )Tj 0.257 Tw T* (\001\017\030\024\022\024\036 \030\026\f\023\030\024\f\021\030\026\027\036\ \027\017\036, \022\024\020\007\026 \f\021\026\035\017 \023\024\016\r\035\ \016\021\034\f\016 )Tj 0.148 Tw T* (\017\f\f\035\036\007\024\r\026\027\017\016 \f)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\034\001\036\005 \r\t\002\024\030\022\024\005 \023\026\006\017\ \036\027\021\024\r, \007\035\017)Tj 0 Tw (-)Tj 0.064 Tw T* (\021\036\035\034\027\t\n \023\036\030\017\024\007\024\n \027\026\002\035\ \033\007\036\027\017\016, \017)Tj /Span<>> BDC ( )Tj EMC (\004\026\f\021\034 \017)Tj /Span<>> BDC ( )Tj EMC (\027\017\b \002\t\035\017 )Tj 0 Tw T* (\030\026\027\007\024\n\017\017\030\024\r\026\027\027\t\n\017 \(\230\026\ \002\035.)Tj /Span<>> BDC ( )Tj EMC (1\).)Tj 0.142 Tw T* (Chung)Tj /Span<>> BDC ( )Tj EMC (W. \017 \f\024\026\r\021. \r)Tj /Span<>> BDC ( )Tj EMC (2009 \020. \023\030\024\r\036\035\017 \030\036\021\030\024\f\023\036\022\ \021\017\r)Tj 0 Tw (-)Tj 0.217 Tw T* (\027\024\036 \017\f\f\035\036\007\024\r\026\027\017\036, \020\007\036 \f\ \030\026\r\027\017\035\017 4 \n\036\021\024\007\026 \035\036\004\036\027\ \017\016 )Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 0 Tw 9 0 0 9 70.8661 730.483 Tm (\020\004\206\f\t\204\004 1.)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf ( \212\037\033\037\021\035\016\033\022\024\035\022\021\037 \022\024\024\027\ \016\b\034\036\037\020\022\004 \036\034\001\016\b\001\022\002 \036)Tj /Span<>> BDC ( )Tj EMC [(\034\025\031\034\033 \027\022\035\016\033\037)0.5(\035\023\033\032)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf -0.027 Tc 0.027 Tw 0 -1.2 TD [(T)0.5(a)-35.3(b)-40.7(l)-38.7(e)-27( 1)-24.5(.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf 0 Tc 0 Tw 3.324 0 Td [( C)-1.1(ha)-4.2(r)3.3(a)-9.1(c)-32.4(t)-1.6(e)-6(r)-39(i)6.6(s)-14.8(t)-29.1(i)-1.8(c)-26.7(s o)4.1(f)]TJ /Span<>> BDC ( )Tj EMC [(t)-10.6(h)-2.4(e s)-14.8(t)-1.1(u)-5.9(d)-2.9(i)-1.4(e)-22(s i)3.9(n)-2.9(c)-1.1(lu)-5.9(d)-5.3(e)-12.8(d i)3.9(n r)-2(e)-8.2(v)-32.5(i)-1.4(e)-7.9(w o)4(f)]TJ /Span<>> BDC ( )Tj EMC [(t)-10.6(h)-2.4(e li)-3.3(t)-1.6(e)-6(r)3.3(a)-9.2(t)-1.1(u)1.6(r)-2(e)]TJ ET 0 0 0 1 K 0.5 w /GS2 gs q 1 0 0 1 70.8661 715.181 cm 0 0 m 37.1 0 l S Q q 1 0 0 1 71.1161 665.5618 cm 0 0 m 0 49.369 l S Q q 1 0 0 1 107.9666 715.181 cm 0 0 m 39.685 0 l S Q q 1 0 0 1 107.9666 665.5618 cm 0 0 m 0 49.369 l S Q q 1 0 0 1 147.6516 715.181 cm 0 0 m 70.866 0 l S Q q 1 0 0 1 147.6516 665.5618 cm 0 0 m 0 49.369 l S Q q 1 0 0 1 218.5177 715.181 cm 0 0 m 22.677 0 l S Q q 1 0 0 1 218.5177 665.5618 cm 0 0 m 0 49.369 l S Q q 1 0 0 1 241.1949 715.181 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 241.1949 665.5618 cm 0 0 m 0 49.369 l S Q q 1 0 0 1 297.8878 715.181 cm 0 0 m 36.85 0 l S Q q 1 0 0 1 297.8878 665.5618 cm 0 0 m 0 49.369 l S Q q 1 0 0 1 334.7382 715.181 cm 0 0 m 51.024 0 l S Q q 1 0 0 1 334.7382 665.5618 cm 0 0 m 0 49.369 l S Q q 1 0 0 1 385.7618 715.181 cm 0 0 m 73.701 0 l S Q q 1 0 0 1 385.7618 665.5618 cm 0 0 m 0 49.369 l S Q q 1 0 0 1 459.4626 715.181 cm 0 0 m 65.447 0 l S Q q 1 0 0 1 459.4626 665.5618 cm 0 0 m 0 49.369 l S Q q 1 0 0 1 524.6594 665.5618 cm 0 0 m 0 49.369 l S Q q 1 0 0 1 70.8661 665.3118 cm 0 0 m 37.1 0 l S Q q 1 0 0 1 71.1161 653.8505 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 107.9666 665.3118 cm 0 0 m 39.685 0 l S Q q 1 0 0 1 107.9666 653.8505 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 147.6516 665.3118 cm 0 0 m 70.866 0 l S Q q 1 0 0 1 147.6516 653.8505 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 218.5177 665.3118 cm 0 0 m 22.677 0 l S Q q 1 0 0 1 218.5177 653.8505 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 241.1949 665.3118 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 241.1949 653.8505 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 297.8878 665.3118 cm 0 0 m 36.85 0 l S Q q 1 0 0 1 297.8878 653.8505 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 334.7382 665.3118 cm 0 0 m 51.024 0 l S Q q 1 0 0 1 334.7382 653.8505 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 385.7618 665.3118 cm 0 0 m 73.701 0 l S Q q 1 0 0 1 385.7618 654.1005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 459.4626 665.3118 cm 0 0 m 65.447 0 l S Q q 1 0 0 1 459.4626 654.1005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 654.1005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 71.1161 634.9005 cm 0 0 m 0 18.95 l S Q q 1 0 0 1 107.9666 634.9005 cm 0 0 m 0 18.95 l S Q q 1 0 0 1 147.6516 634.9005 cm 0 0 m 0 18.95 l S Q q 1 0 0 1 218.5177 634.9005 cm 0 0 m 0 18.95 l S Q q 1 0 0 1 241.1949 634.9005 cm 0 0 m 0 18.95 l S Q q 1 0 0 1 297.8878 634.9005 cm 0 0 m 0 18.95 l S Q q 1 0 0 1 334.7382 634.9005 cm 0 0 m 0 18.95 l S Q q 1 0 0 1 385.5118 653.8505 cm 0 0 m 73.951 0 l S Q q 1 0 0 1 385.7618 634.9005 cm 0 0 m 0 18.7 l S Q q 1 0 0 1 459.4626 653.8505 cm 0 0 m 65.447 0 l S Q q 1 0 0 1 459.4626 634.9005 cm 0 0 m 0 18.7 l S Q q 1 0 0 1 524.6594 634.9005 cm 0 0 m 0 18.7 l S Q q 1 0 0 1 70.8661 634.6505 cm 0 0 m 37.1 0 l S Q q 1 0 0 1 71.1161 613.5892 cm 0 0 m 0 20.811 l S Q q 1 0 0 1 107.9666 634.6505 cm 0 0 m 39.685 0 l S Q q 1 0 0 1 107.9666 613.5892 cm 0 0 m 0 20.811 l S Q q 1 0 0 1 147.6516 634.6505 cm 0 0 m 70.866 0 l S Q q 1 0 0 1 147.6516 613.5892 cm 0 0 m 0 20.811 l S Q q 1 0 0 1 218.5177 634.6505 cm 0 0 m 22.677 0 l S Q q 1 0 0 1 218.5177 613.5892 cm 0 0 m 0 20.811 l S Q q 1 0 0 1 241.1949 634.6505 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 241.1949 613.8392 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 297.8878 634.6505 cm 0 0 m 36.85 0 l S Q q 1 0 0 1 297.8878 613.8392 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 334.7382 634.6505 cm 0 0 m 51.024 0 l S Q q 1 0 0 1 334.7382 613.5892 cm 0 0 m 0 20.811 l S Q q 1 0 0 1 385.7618 634.6505 cm 0 0 m 73.701 0 l S Q q 1 0 0 1 385.7618 613.5892 cm 0 0 m 0 20.811 l S Q q 1 0 0 1 459.4626 634.6505 cm 0 0 m 65.447 0 l S Q q 1 0 0 1 459.4626 613.5892 cm 0 0 m 0 20.811 l S Q q 1 0 0 1 524.6594 613.5892 cm 0 0 m 0 20.811 l S Q q 1 0 0 1 71.1161 592.5279 cm 0 0 m 0 21.061 l S Q q 1 0 0 1 107.9666 592.5279 cm 0 0 m 0 21.061 l S Q q 1 0 0 1 147.6516 592.5279 cm 0 0 m 0 21.061 l S Q q 1 0 0 1 218.5177 592.5279 cm 0 0 m 0 21.061 l S Q q 1 0 0 1 240.9449 613.5892 cm 0 0 m 57.193 0 l S Q q 1 0 0 1 241.1949 592.7779 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 297.8878 592.7779 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 334.7382 592.5279 cm 0 0 m 0 21.061 l S Q q 1 0 0 1 385.7618 592.5279 cm 0 0 m 0 21.061 l S Q q 1 0 0 1 459.4626 592.5279 cm 0 0 m 0 21.061 l S Q q 1 0 0 1 524.6594 592.5279 cm 0 0 m 0 21.061 l S Q q 1 0 0 1 71.1161 571.7166 cm 0 0 m 0 20.811 l S Q q 1 0 0 1 107.9666 571.7166 cm 0 0 m 0 20.811 l S Q q 1 0 0 1 147.6516 571.7166 cm 0 0 m 0 20.811 l S Q q 1 0 0 1 218.5177 571.7166 cm 0 0 m 0 20.811 l S Q q 1 0 0 1 240.9449 592.5279 cm 0 0 m 57.193 0 l S Q q 1 0 0 1 241.1949 571.7166 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 297.8878 571.7166 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 334.7382 571.7166 cm 0 0 m 0 20.811 l S Q q 1 0 0 1 385.7618 571.7166 cm 0 0 m 0 20.811 l S Q q 1 0 0 1 459.4626 571.7166 cm 0 0 m 0 20.811 l S Q q 1 0 0 1 524.6594 571.7166 cm 0 0 m 0 20.811 l S Q q 1 0 0 1 70.8661 571.4666 cm 0 0 m 37.1 0 l S Q q 1 0 0 1 71.1161 550.4053 cm 0 0 m 0 20.811 l S Q q 1 0 0 1 107.9666 571.4666 cm 0 0 m 39.685 0 l S Q q 1 0 0 1 107.9666 550.4053 cm 0 0 m 0 20.811 l S Q q 1 0 0 1 147.6516 571.4666 cm 0 0 m 70.866 0 l S Q q 1 0 0 1 147.6516 550.4053 cm 0 0 m 0 20.811 l S Q q 1 0 0 1 218.5177 571.4666 cm 0 0 m 22.677 0 l S Q q 1 0 0 1 218.5177 550.4053 cm 0 0 m 0 20.811 l S Q q 1 0 0 1 241.1949 571.4666 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 241.1949 550.6553 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 297.8878 571.4666 cm 0 0 m 36.85 0 l S Q q 1 0 0 1 297.8878 550.6553 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 334.7382 571.4666 cm 0 0 m 51.024 0 l S Q q 1 0 0 1 334.7382 550.4053 cm 0 0 m 0 20.811 l S Q q 1 0 0 1 385.7618 571.4666 cm 0 0 m 73.701 0 l S Q q 1 0 0 1 385.7618 550.4053 cm 0 0 m 0 20.811 l S Q q 1 0 0 1 459.4626 571.4666 cm 0 0 m 65.447 0 l S Q q 1 0 0 1 459.4626 550.4053 cm 0 0 m 0 20.811 l S Q q 1 0 0 1 524.6594 550.4053 cm 0 0 m 0 20.811 l S Q q 1 0 0 1 71.1161 529.5941 cm 0 0 m 0 20.811 l S Q q 1 0 0 1 107.9666 529.5941 cm 0 0 m 0 20.811 l S Q q 1 0 0 1 147.6516 529.5941 cm 0 0 m 0 20.811 l S Q q 1 0 0 1 218.5177 529.5941 cm 0 0 m 0 20.811 l S Q q 1 0 0 1 240.9449 550.4053 cm 0 0 m 57.193 0 l S Q q 1 0 0 1 241.1949 529.5941 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 297.8878 529.5941 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 334.7382 529.5941 cm 0 0 m 0 20.811 l S Q q 1 0 0 1 385.7618 529.5941 cm 0 0 m 0 20.811 l S Q q 1 0 0 1 459.4626 529.5941 cm 0 0 m 0 20.811 l S Q q 1 0 0 1 524.6594 529.5941 cm 0 0 m 0 20.811 l S Q q 1 0 0 1 70.8661 529.3441 cm 0 0 m 37.1 0 l S Q q 1 0 0 1 71.1161 517.8828 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 107.9666 529.3441 cm 0 0 m 39.685 0 l S Q q 1 0 0 1 107.9666 517.8828 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 147.6516 529.3441 cm 0 0 m 70.866 0 l S Q q 1 0 0 1 147.6516 517.8828 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 218.5177 529.3441 cm 0 0 m 22.677 0 l S Q q 1 0 0 1 218.5177 517.8828 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 241.1949 529.3441 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 241.1949 517.8828 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 297.8878 529.3441 cm 0 0 m 36.85 0 l S Q q 1 0 0 1 297.8878 517.8828 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 334.7382 529.3441 cm 0 0 m 51.024 0 l S Q q 1 0 0 1 334.7382 517.8828 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 385.7618 529.3441 cm 0 0 m 73.701 0 l S Q q 1 0 0 1 385.7618 518.1328 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 459.4626 529.3441 cm 0 0 m 65.447 0 l S Q q 1 0 0 1 459.4626 518.1328 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 518.1328 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 71.1161 498.9328 cm 0 0 m 0 18.95 l S Q q 1 0 0 1 107.9666 498.9328 cm 0 0 m 0 18.95 l S Q q 1 0 0 1 147.6516 498.9328 cm 0 0 m 0 18.95 l S Q q 1 0 0 1 218.5177 498.9328 cm 0 0 m 0 18.95 l S Q q 1 0 0 1 241.1949 498.9328 cm 0 0 m 0 18.95 l S Q q 1 0 0 1 297.8878 498.9328 cm 0 0 m 0 18.95 l S Q q 1 0 0 1 334.7382 498.9328 cm 0 0 m 0 18.95 l S Q q 1 0 0 1 385.5118 517.8828 cm 0 0 m 73.951 0 l S Q q 1 0 0 1 385.7618 498.9328 cm 0 0 m 0 18.7 l S Q q 1 0 0 1 459.4626 517.8828 cm 0 0 m 65.447 0 l S Q q 1 0 0 1 459.4626 498.9328 cm 0 0 m 0 18.7 l S Q q 1 0 0 1 524.6594 498.9328 cm 0 0 m 0 18.7 l S Q q 1 0 0 1 70.8661 498.6828 cm 0 0 m 37.1 0 l S Q q 1 0 0 1 71.1161 487.2215 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 107.9666 498.6828 cm 0 0 m 39.685 0 l S Q q 1 0 0 1 107.9666 487.2215 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 147.6516 498.6828 cm 0 0 m 70.866 0 l S Q q 1 0 0 1 147.6516 487.2215 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 218.5177 498.6828 cm 0 0 m 22.677 0 l S Q q 1 0 0 1 218.5177 487.2215 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 241.1949 498.6828 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 241.1949 487.2215 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 297.8878 498.6828 cm 0 0 m 36.85 0 l S Q q 1 0 0 1 297.8878 487.2215 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 334.7382 498.6828 cm 0 0 m 51.024 0 l S Q q 1 0 0 1 334.7382 487.2215 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 385.7618 498.6828 cm 0 0 m 73.701 0 l S Q q 1 0 0 1 385.7618 487.4715 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 459.4626 498.6828 cm 0 0 m 65.447 0 l S Q q 1 0 0 1 459.4626 487.4715 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 487.4715 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 71.1161 475.7602 cm 0 0 m 0 11.461 l S Q q 1 0 0 1 107.9666 475.7602 cm 0 0 m 0 11.461 l S Q q 1 0 0 1 147.6516 475.7602 cm 0 0 m 0 11.461 l S Q q 1 0 0 1 218.5177 475.7602 cm 0 0 m 0 11.461 l S Q q 1 0 0 1 241.1949 475.7602 cm 0 0 m 0 11.461 l S Q q 1 0 0 1 297.8878 475.7602 cm 0 0 m 0 11.461 l S Q q 1 0 0 1 334.7382 475.7602 cm 0 0 m 0 11.461 l S Q q 1 0 0 1 385.5118 487.2215 cm 0 0 m 73.951 0 l S Q q 1 0 0 1 385.7618 476.0102 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 459.4626 487.2215 cm 0 0 m 65.447 0 l S Q q 1 0 0 1 459.4626 476.0102 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 476.0102 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 71.1161 464.5489 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 107.9666 464.5489 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 147.6516 464.5489 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 218.5177 464.5489 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 241.1949 464.5489 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 297.8878 464.5489 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 334.7382 464.5489 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 385.5118 475.7602 cm 0 0 m 73.951 0 l S Q q 1 0 0 1 385.7618 464.5489 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 459.4626 475.7602 cm 0 0 m 65.447 0 l S Q q 1 0 0 1 459.4626 464.5489 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 464.5489 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 464.2989 cm 0 0 m 37.1 0 l S Q q 1 0 0 1 71.1161 452.8376 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 107.9666 464.2989 cm 0 0 m 39.685 0 l S Q q 1 0 0 1 107.9666 452.8376 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 147.6516 464.2989 cm 0 0 m 70.866 0 l S Q q 1 0 0 1 147.6516 452.8376 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 218.5177 464.2989 cm 0 0 m 22.677 0 l S Q q 1 0 0 1 218.5177 452.8376 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 241.1949 464.2989 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 241.1949 452.8376 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 297.8878 464.2989 cm 0 0 m 36.85 0 l S Q q 1 0 0 1 297.8878 452.8376 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 334.7382 464.2989 cm 0 0 m 51.024 0 l S Q q 1 0 0 1 334.7382 452.8376 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 385.7618 464.2989 cm 0 0 m 73.701 0 l S Q q 1 0 0 1 385.7618 453.0876 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 459.4626 464.2989 cm 0 0 m 65.447 0 l S Q q 1 0 0 1 459.4626 453.0876 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 453.0876 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 71.1161 441.6263 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 107.9666 441.6263 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 147.6516 441.6263 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 218.5177 441.6263 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 241.1949 441.6263 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 297.8878 441.6263 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 334.7382 441.6263 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 385.5118 452.8376 cm 0 0 m 73.951 0 l S Q q 1 0 0 1 385.7618 441.6263 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 459.4626 452.8376 cm 0 0 m 65.447 0 l S Q q 1 0 0 1 459.4626 441.6263 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 441.6263 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 441.3763 cm 0 0 m 37.1 0 l S Q q 1 0 0 1 71.1161 420.3151 cm 0 0 m 0 20.811 l S Q q 1 0 0 1 107.9666 441.3763 cm 0 0 m 39.685 0 l S Q q 1 0 0 1 107.9666 420.3151 cm 0 0 m 0 20.811 l S Q q 1 0 0 1 147.6516 441.3763 cm 0 0 m 70.866 0 l S Q q 1 0 0 1 147.6516 420.3151 cm 0 0 m 0 20.811 l S Q q 1 0 0 1 218.5177 441.3763 cm 0 0 m 22.677 0 l S Q q 1 0 0 1 218.5177 420.3151 cm 0 0 m 0 20.811 l S Q q 1 0 0 1 241.1949 441.3763 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 241.1949 420.5651 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 297.8878 441.3763 cm 0 0 m 36.85 0 l S Q q 1 0 0 1 297.8878 420.5651 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 334.7382 441.3763 cm 0 0 m 51.024 0 l S Q q 1 0 0 1 334.7382 420.3151 cm 0 0 m 0 20.811 l S Q q 1 0 0 1 385.7618 441.3763 cm 0 0 m 73.701 0 l S Q q 1 0 0 1 385.7618 420.5651 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 459.4626 441.3763 cm 0 0 m 65.447 0 l S Q q 1 0 0 1 459.4626 420.5651 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 524.6594 420.5651 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 71.1161 409.1038 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 107.9666 409.1038 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 147.6516 409.1038 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 218.5177 409.1038 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 240.9449 420.3151 cm 0 0 m 57.193 0 l S Q q 1 0 0 1 241.1949 409.1038 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 297.8878 409.1038 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 334.7382 409.1038 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 385.5118 420.3151 cm 0 0 m 73.951 0 l S Q q 1 0 0 1 385.7618 409.1038 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 459.4626 420.3151 cm 0 0 m 65.447 0 l S Q q 1 0 0 1 459.4626 409.1038 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 409.1038 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 408.8538 cm 0 0 m 37.1 0 l S Q q 1 0 0 1 71.1161 397.3925 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 107.9666 408.8538 cm 0 0 m 39.685 0 l S Q q 1 0 0 1 107.9666 397.3925 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 147.6516 408.8538 cm 0 0 m 70.866 0 l S Q q 1 0 0 1 147.6516 397.3925 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 218.5177 408.8538 cm 0 0 m 22.677 0 l S Q q 1 0 0 1 218.5177 397.3925 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 241.1949 408.8538 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 241.1949 397.3925 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 297.8878 408.8538 cm 0 0 m 36.85 0 l S Q q 1 0 0 1 297.8878 397.3925 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 334.7382 408.8538 cm 0 0 m 51.024 0 l S Q q 1 0 0 1 334.7382 397.3925 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 385.7618 408.8538 cm 0 0 m 73.701 0 l S Q q 1 0 0 1 385.7618 397.6425 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 459.4626 408.8538 cm 0 0 m 65.447 0 l S Q q 1 0 0 1 459.4626 397.6425 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 397.6425 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 71.1161 378.4425 cm 0 0 m 0 18.95 l S Q q 1 0 0 1 107.9666 378.4425 cm 0 0 m 0 18.95 l S Q q 1 0 0 1 147.6516 378.4425 cm 0 0 m 0 18.95 l S Q q 1 0 0 1 218.5177 378.4425 cm 0 0 m 0 18.95 l S Q q 1 0 0 1 241.1949 378.4425 cm 0 0 m 0 18.95 l S Q q 1 0 0 1 297.8878 378.4425 cm 0 0 m 0 18.95 l S Q q 1 0 0 1 334.7382 378.4425 cm 0 0 m 0 18.95 l S Q q 1 0 0 1 385.5118 397.3925 cm 0 0 m 73.951 0 l S Q q 1 0 0 1 385.7618 378.4425 cm 0 0 m 0 18.7 l S Q q 1 0 0 1 459.4626 397.3925 cm 0 0 m 65.447 0 l S Q q 1 0 0 1 459.4626 378.4425 cm 0 0 m 0 18.7 l S Q q 1 0 0 1 524.6594 378.4425 cm 0 0 m 0 18.7 l S Q q 1 0 0 1 70.8661 378.1925 cm 0 0 m 37.1 0 l S Q q 1 0 0 1 107.9666 378.1925 cm 0 0 m 39.685 0 l S Q q 1 0 0 1 147.6516 378.1925 cm 0 0 m 70.866 0 l S Q q 1 0 0 1 218.5177 378.1925 cm 0 0 m 22.677 0 l S Q q 1 0 0 1 241.1949 378.1925 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 297.8878 378.1925 cm 0 0 m 36.85 0 l S Q q 1 0 0 1 334.7382 378.1925 cm 0 0 m 51.024 0 l S Q q 1 0 0 1 385.7618 378.1925 cm 0 0 m 73.701 0 l S Q q 1 0 0 1 459.4626 378.1925 cm 0 0 m 65.447 0 l S Q BT /GS1 gs /T1_0 1 Tf 8 0 0 8 76.3975 687.3463 Tm (\032\003\002\006\013)Tj 4.959 0 Td (\255\003\006\004\b\004)Tj 4.439 0 Td (\020\t\212 \t\217\217\f\r\240\002\004\b\t\235)Tj 9.02 0 Td (\027\002\240)Tj 4.395 0.6 Td (\215\r\003\002\240 )Tj -0.478 -1.2 Td (\f\r\201\r\b\t\235)Tj 6.328 1.2 Td (\030\t\217\f\002 )Tj -0.574 -1.2 Td (\206\002\f\001\b\013\216)Tj 5.754 1.8 Td (\200\r\006\t\002\240 )Tj -1.077 -1.2 Td (\b\004\206\f\211\240\r\b\t\235 )Tj 1.345 -1.2 Td (\(\214\r\217.\))Tj 6.26 1.2 Td (\020\t\212\013 \217\t\227\r\005)Tj 9.92 2.4 Td (\030\004\217\003\002\003\004 )Tj -1.804 -1.2 Td (\013\213\240\002\006\002\f\r\b\t\235 )Tj -0.175 -1.2 Td (\212\006\t)Tj /Span<>> BDC ( )Tj EMC (\212\006\t\214\r\b\r\b\t\t )Tj 0.687 -1.2 Td (\233\t\206\006\t\b\002\002\n\002 )Tj 1.076 -1.2 Td (\220\f\r\235\(%\))Tj /T1_1 1 Tf -50.38 -1.433 Td (Hjortrup )Tj 0 -1.2 TD (A. et al.)Tj 5.452 1.2 Td (\212\026\027\017\016)Tj 4.721 0 Td (\203\036\030\026\027\007\024\n\017\017\030\024)Tj (-)Tj -0.114 -1.2 Td (\r\026\027\027\024\036, \215\030\024\f\023\036\022)Tj (-)Tj 2.157 -1.2 Td (\021\017\r\027\024\036)Tj 6.271 2.4 Td (1991)Tj 3.312 0 Td (\205\017\002\030\017\027\024\r\t\005 )Tj 1.688 -1.2 Td (\022\035\036\005)Tj 6.307 1.2 Td (23)Tj 5.492 0 Td (19)Tj 4.34 0 Td (\230\030\026\027\f\f\235\017\027\022\021\036\030\027\t\036)Tj 11.794 0 Td (52,0)Tj -11.848 -1.433 Td (\236\027\021\030\026\f\235\017\027\022\021\036\030\027\t\036)Tj 11.848 0 Td (45,0)Tj -51.421 -2.4 Td (Chung W. )Tj 0 -1.2 TD (et al.)Tj 5.255 1.2 Td (\025\026\027\026\007\026)Tj 4.848 0 Td (\217\036\021\030\024\f\023\036\022\021\017\r\027\024\036)Tj 8.384 0 Td (2009)Tj 3.312 0 Td (\205\017\002\030\017\027\024\r\t\005 )Tj 1.688 -1.2 Td (\022\035\036\005)Tj 6.057 1.2 Td (232)Tj 5.992 0 Td (3)Tj 4.09 0 Td (\230\030\026\027\f\f\235\017\027\022\021\036\030\027\t\036)Tj 11.794 0 Td (39,1)Tj -29.936 -2.633 Td (\025\024\035\035\026\020\036\027\024\r\t\005 )Tj 1.254 -1.2 Td (\017\n\023\035\026\027\021)Tj -0.768 -1.433 Td (\203\017\r\036\007\036\027\017\036 )Tj 0.897 -1.2 Td (\035\024\f\022\031\021\026)Tj -22.868 -1.433 Td (Altomare )Tj T* (D. Et al.)Tj 5.265 1.2 Td (\236\021\026\035\017\016)Tj 4.718 0 Td (\217\026\027\007\024\n\017\017\030\024\r\026\027)Tj (-)Tj 2.919 -1.2 Td (\027\024\036)Tj 5.585 1.2 Td (2009)Tj 3.312 0 Td (\205\017\002\030\017\027\024\r\t\005 )Tj 1.688 -1.2 Td (\022\035\036\005)Tj 6.307 1.2 Td (39)Tj 5.492 0 Td (12)Tj 4.34 0 Td (\230\030\026\027\f\f\235\017\027\022\021\036\030\027\t\036)Tj 11.794 0 Td (50,0)Tj -28.819 -2.633 Td (\217\036\032\031\013\026\016 )Tj 0.038 -1.2 Td (\035\017\020\026\021\031\030\026)Tj -22.641 -1.433 Td (Nadav )Tj T* (Haim M. )Tj T* (et al)Tj 5.007 2.4 Td (\236\030\026\017\035\034)Tj 5.114 0 Td (\204\027\024\020\024\006\036\027\021\030\024\r\024\036, )Tj -0.017 -1.2 Td (\217\036\021\030\024\f\023\036\022\021\017\r\027\024\036)Tj 8.384 1.2 Td (2011)Tj 3.312 0 Td (\205\017\002\030\017\027\024\r\t\005 )Tj 1.688 -1.2 Td (\022\035\036\005)Tj 6.307 1.2 Td (60)Tj 5.742 0 Td (6)Tj 4.09 0 Td (\230\030\026\027\f\f\235\017\027\022\021\036\030\027\t\036)Tj 11.794 0 Td (63,0)Tj -11.965 -1.433 Td (\225\022\f\021\030\026\f\235\017\027\022\021\036\030\027\t\036)Tj 11.965 0 Td (54,0)Tj -51.421 -2.4 Td (Mishra A. )Tj T* (et al.)Tj 5.421 1.2 Td (\236\027\007\017\016)Tj 4.752 0 Td (\203\036\030\026\027\007\024\n\017\017\030\024)Tj (-)Tj -0.114 -1.2 Td (\r\026\027\027\024\036, \215\030\024\f\023\036\022)Tj (-)Tj 2.157 -1.2 Td (\021\017\r\027\024\036)Tj 6.271 2.4 Td (2013)Tj 3.312 0 Td (\205\017\002\030\017\027\024\r\t\005 )Tj 1.688 -1.2 Td (\022\035\036\005)Tj 6.307 1.2 Td (30)Tj 5.742 0 Td (6)Tj 4.036 0 Td (\236\027\021\030\026\f\235\017\027\022\021\036\030\027\t\036)Tj 11.598 0 Td (81,25)Tj -11.544 -1.433 Td (\230\030\026\027\f\f\235\017\027\022\021\036\030\027\t\036)Tj 11.794 0 Td (75,0)Tj -11.965 -1.433 Td (\225\022\f\021\030\026\f\235\017\027\022\021\036\030\027\t\036)Tj 11.715 0 Td (57,14)Tj -51.171 -1.433 Td (Cestaro )Tj T* (G. et al.)Tj 5.265 1.2 Td (\236\021\026\035\017\016)Tj 4.718 0 Td (\217\026\027\007\024\n\017\017\030\024\r\026\027)Tj (-)Tj 2.919 -1.2 Td (\027\024\036)Tj 5.585 1.2 Td (2014)Tj 3.312 0 Td (\205\017\002\030\017\027\024\r\t\005 )Tj 1.688 -1.2 Td (\022\035\036\005)Tj 6.307 1.2 Td (26)Tj 5.742 0 Td (7)Tj 4.036 0 Td (\236\027\021\030\026\f\235\017\027\022\021\036\030\027\t\036)Tj 11.848 0 Td (66,7)Tj -11.794 -1.433 Td (\230\030\026\027\f\f\235\017\027\022\021\036\030\027\t\036)Tj 11.794 0 Td (70,0)Tj -51.421 -1.433 Td (Portilla F. )Tj T* (et al.)Tj 4.763 1.2 Td (\206\036\030\n\026\027\017\016)Tj 5.221 0 Td (\217\026\027\007\024\n\017\017\030\024\r\026\027)Tj (-)Tj 2.919 -1.2 Td (\027\024\036)Tj 5.585 1.2 Td (2019)Tj 3.312 0 Td (\205\017\002\030\017\027\024\r\t\005 )Tj 1.688 -1.2 Td (\022\035\036\005)Tj 6.307 1.2 Td (24)Tj 5.492 0 Td (60)Tj 4.34 0 Td (\230\030\026\027\f\f\235\017\027\022\021\036\030\027\t\036)Tj 11.794 0 Td (55,0)Tj -29.574 -2.633 Td (PRP-\021\036\030\026\023\017\016)Tj 17.61 0 Td (\225\022\f\021\030\026\f\235\017\027\022\021\036\030\027\t\036)Tj 11.965 0 Td (48,0)Tj -51.421 -1.433 Td (\205\030\024\035\024\r )Tj T* (\224.\202. )Tj 0 -1.2 TD (\017)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021.)Tj 5.295 2.4 Td (\217\024\f\f\017\016)Tj 4.762 0 Td (\203\036 \030\026\027\007\024\n\017\017\030\024)Tj (-)Tj -0.061 -1.2 Td (\r\026\027\027\024\036; \215\030\024\f\023\036\022)Tj (-)Tj 2.22 -1.2 Td (\021\017\r\027\024\036)Tj 6.271 2.4 Td (2023)Tj 3.312 0 Td (\205\017\002\030\017\027\024\r\t\005 )Tj 1.688 -1.2 Td (\022\035\036\005)Tj 6.307 1.2 Td (28)Tj 5.492 0 Td (42)Tj 4.286 0 Td (\236\027\021\030\026\f\235\017\027\022\021\036\030\027\t\036)Tj 11.848 0 Td (92,3)Tj -11.794 -1.433 Td (\230\030\026\027\f\f\235\017\027\022\021\036\030\027\t\036)Tj 11.794 0 Td (86,6)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\206)10(\002\036\033 \035\030\032\003\033)30(\n)42(\032)-21(\230\033\241)]TJ 57.136 0 Td (REVIEW)Tj -57.136 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 2)69(4, \023\0224, 202)23(5)]TJ 43.013 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 2)69(4, \023\0224, 202)23(5)]TJ /T1_4 1 Tf 25 0 0 25 20.8276 56.0378 Tm (170)Tj ET endstream endobj 1192 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\034\201\021\024\016\215\016\215\021\016 \223\021\235\201\021\215\025\r\025\ \202)10(\025 \017)-10(\t\016\004 \021\022\235\021\025\222\t\001\b)-10(\026\021\f\016\b\017\021 \021\024\222\t\001\215\026)11(\025\r )]TJ 0 -1 TD [(\r\022\t\016\f\016\215\021\021 \b\r\021\232\016\207 \222\201\004\024\025\ \207 \017\021\020\017\021 \(\025\235\213\025\201\022\t\021\026)11(\016\201\001\026)-19.9(\200\201\220\))]TJ 32.168 1 Td [(Fibrin glue and bioplastic implants in tr)31(eatment of\022r)31(ectal f)-21(istulas \(r)31(e)11(vie)11(w\))]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0.112 Tw 10 0 0 10 42.5197 724.8299 Tm (\212\026\027\027\t\005 \026\027\026\035\017 \035\017\021\036\030\026\021\ \031\030\t \027\026\023\030\026\r\035\036\027 \027\026)Tj /Span<>> BDC ( )Tj EMC (\024\023\030\036\007\036\035\036)Tj 0 Tw (-)Tj 0.454 Tw 0 -1.218 TD [(\027\017\036 )0.5(\220\235\235\036\022\021\017\r\027\024\f\021\017 )0.5(\023\030\017\n\036\027\036\027\017\016 )0.5(\002\017\024\023\035\026\f\021\017\004\036\f\022\017\b )]TJ 0 Tw T* (\n\026\021\036\030\017\026\035\024\r \r)Tj /Span<>> BDC ( )Tj EMC (\035\036\004\036\027\017\017 \f\r\017\013\036\005 \023\030\016\n\024\005\ \022\017\001\022\017.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.01 Tc 0.018 Tw 14 0 0 14 42.5896 663.9399 Tm [(\f\026\017\031\034\022\024\232)5( \031)5(\016)-18.3(\240\034)-31(\024)35(\037\226\232)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0.02 Tc 0.422 Tw 10 0 0 10 42.5197 639.5839 Tm [(\212\035\016 \023\024\007\020\024\021\024\r\022\017 \024\002\024\030\026\ \002\t\035 \023\030\024\017\r\036\007\036\027 \023\024\017\f\022)20( )]TJ 0.545 Tw T* (\035\017\021\036\030\026\021\031\030\t \r)Tj /Span<>> BDC ( )Tj EMC [(\027\026\031\022\024\n\036\021\030\017\004\036\f\022\017\b \002\026\026\ \b \007\026\027\027\t\b)20( )]TJ 0.299 Tw T* [(P)20(ubMed, )0.5(eL)-32(ibr)-33(ar)-23.9(y )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 9.137 0 Td [(K)25(ohr)-33(ane. )0.5(\214\017\021\036\030\026\021\031\030\026 )0.5(\007\024\035\032\027\026)20( )]TJ 0.031 Tw -9.137 -1.218 Td [(\002\t\035\026 )0.5(\002\t\021\034 \024\023\031\002\035\017\022\024\r\026\027\026 \f)]TJ /Span<>> BDC ( )Tj EMC [(2009 )0.5(\023\024)]TJ /Span<>> BDC ( )Tj EMC [(2023 \020\020., )0.5(\027\026)]TJ /Span<>> BDC ( )Tj EMC (\026\027)Tj 0 Tc 0 Tw (-)Tj 0.02 Tc -0.018 Tw T* [(\020\035\017\005\f\022\024\n )0.5(\017\035\017 )0.5(\030\031\f\f\022\024\n )0.5(\016\t\022\036. )0.5(\215\024\017\f\022 )0.5(\024\f\031\013\036\f\021\r\035\016\035\f\016)20( )]TJ 0.068 Tw T* (\023\024)Tj /Span<>> BDC ( )Tj EMC [(\022\035\033\004\036\r\t\n \f\035\024\r\026\n: anal f)-27.9(istul)-16(a pl)35(ug, anal f)-28(istul)-16(a)20( )]TJ 0.069 Tw T* [(coll)-15.9(a)-17(gen pl)35(ug, f)-28(ibr)-37(in gl)35(ueseal)-15.9(ant, tr)-23.9(ea)15(tment)]TJ /Span<>> BDC ( )Tj EMC (\227 \017)Tj /Span<>> BDC ( )Tj EMC [(\023\024)20( )]TJ -0.045 Tw T* [(\023\024\017\f\022\024\r\024\n\031 \026\023\030\024\f\031: \(anal f)-28(i)-16(istul)-16(a OR f)-28(istul)-16(a-in-ano)20( )]TJ 0.213 Tw 0 -1.218 TD [(OR per)-37(ianal f)-28(istul)-16(a\) A)51(ND tr)-23.9(ea)15(tment A)51(ND \(coll)-16(a)-17(gen)19.9( )]TJ 0.071 Tw 0 -1.218 TD [(pl)35(ug OR f)-28(ibr)-37(in gl)35.1(ue OR biopl)-15.9(ast)-32(ic ma)15(ter)-36.9(ial\); \235\017\002\030\017)]TJ 0 Tc 0 Tw (-)Tj 0.02 Tc 0.105 Tw 0 -1.218 TD (\027\024\r\t\005 \022\035\036\005 \236\214\236 \f\r\017\013 \023\030\016\ \n\024\005 \022\017\001\022\017 \236\214\236 \023\030\016\n\024)Tj 0 Tc 0 Tw (-)Tj 0.02 Tc 0.187 Tw T* (\022\017\001\036\004\027\t\005 \f\r\017\013 \236\214\236 \022\024\035\035\ \026\020\036\027\024\r\t\005 \002\017\024\023\035\026\f\021\017\004\036)Tj 0 Tc 0 Tw (-)Tj 0.02 Tc -0.019 Tw T* [(\f\022\017\005 \n\026\021\036\030\017\026\035 \236\214\236 \022\024\035\035\ \026\020\036\027\024\r\t\005 \017\n\023\035\026\027\021\026\021. \207\t\035\ \024)20( )]TJ 0.203 Tw T* (\027\026\005\007\036\027\024 842 \f\021\026\021\034\017 \023\024)Tj /Span<>> BDC ( )Tj EMC (\007\026\027\027\024\n\031 \026\023\030\024\f\031. \236)Tj /Span<>> BDC ( )Tj EMC [(\027\017\b)20( )]TJ 0.158 Tw T* (19 \026\027\020\035\024\016\t\004\027\t\b \017)Tj /Span<>> BDC ( )Tj EMC (1 \f\021\026\021\034\016 \030\031\f\f\022\024\016\t\004\027\026\016 \r)Tj /Span<>> BDC ( )Tj EMC (\023\036)Tj 0 Tc 0 Tw (-)Tj 0.02 Tc 0.155 Tw T* (\030\017\024\007 \f)Tj /Span<>> BDC ( )Tj EMC (2009 \023\024)Tj /Span<>> BDC ( )Tj EMC [(2023 \020\020. \215\026\030\026\n\036\021\030\024\n \017\f\022\035\033\004\ \036\027\017\016)20( )]TJ 0.042 Tw T* (\002\t\035\017 \f\r\017\013\017, \026\f\f\024\006\017\017\030\024\r\026\027\ \027\t\036 \f)Tj /Span<>> BDC ( )Tj EMC [(\r\024\f\023\026\035\017\021\036\035\034\027\t\n\017)20( )]TJ 0.663 Tw T* [(\026\002\024\035\036\r\026\027\017\016\n\017 \022\017\001\036\004\027\017\ \022\026, \023\024\f\021\021\030\026\r\n\026\021\017\004\036\f\022\017\036\ )20( )]TJ 0.176 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\023\024\f\021\035\031\004\036\r\t\036. \210\021\002\024\030 \f\021\026\021\ \036\005 \023\030\024\017\f\b\024\007\017\035 \023\024)Tj /Span<>> BDC ( )Tj EMC (\f\035\036)Tj 0 Tc 0 Tw (-)Tj 0.02 Tc 0.269 Tw T* [(\007\031\033\013\017\n )0.5(\022\030\017\021\036\030\017\016\n: )0.5(\f\021\030\031\022\021\031\030\017\030\024\r\026\027\027\024\f\021\034, \ )0.5(\035\024\020\017\004)]TJ 0 Tc 0 Tw (-)Tj 0.02 Tc 0.32 Tw T* (\027\024\f\021\034, \026\022\021\031\026\035\034\027\024\f\021\034 \017)Tj /Span<>> BDC ( )Tj EMC [(\007\024\022\026\026\021\036\035\034\027\024\f\021\034 \(\027\026\035\017\ \004\017\036)20( )]TJ 0.178 Tw T* (\023\024\007\021\r\036\030\032\007\026\033\013\017\b \235\026\022\021\t \ \f\f\t\035\024\022 \027\026)Tj /Span<>> BDC ( )Tj EMC [(\024\030\017\020\017\027\026\035\034\027\t\036)20( )]TJ 0.498 Tw T* (\017\f\f\035\036\007\024\r\026\027\017\016\) \021\036\022\f\021\026, \017\ \027\235\024\030\n\026\006\017\016 \024)Tj /Span<>> BDC ( )Tj EMC [(\021\036\n\026\021\017\022\036)20( )]TJ 0.169 Tw 23.244 35.316 Td (\023\031\002\035\017\022\026\006\017\005 \026\r\021\024\030\026, \022\024\ \035\017\004\036\f\021\r\024 \006\017\021\017\030\024\r\026\027\017\005 \ \f\021\026)Tj 0 Tc 0 Tw (-)Tj 0.02 Tc 0.175 Tw T* (\021\036\005. \210\007\027\017\n \017)Tj /Span<>> BDC ( )Tj EMC [(\020\030\031\023\023\t \002\017\024\035\024\020\017\004\036\f\022\017\b \ \n\026\021\036\030\017\026\035\024\r)20( )]TJ 0.497 Tw T* [(\016\r\035\016\036\021\f\016 \007\r\031\b\022\024\n\023\024\027\036\027\021\ \027\t\005 \235\017\002\030\017\027\024\r\t\005 \022\035\036\005:)20( )]TJ 0.197 Tw T* [(T)35(issucolk)-16(i)-24(t\256 \(Baxter)]TJ /Span<>> BDC ( )Tj EMC (\227 \202\r\f\021\030\017\016\) \017)Tj /Span<>> BDC ( )Tj EMC [(Ev)-15.9(icel\256 \(Omr)-36.9(ix)20( )]TJ 0.136 Tw T* [(Biophar)-15.9(ma)-17(ceut)-32(icals, )0.5(L)45(td.)]TJ /Span<>> BDC ( )Tj EMC 10.943 0 Td [(\227 )0.5(\236\030\026\017\035\034\) )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC 6.623 0 Td [(\030\026\035\017\004\027\024\005)20( )]TJ 0.223 Tw -17.566 -1.218 Td (\022\024\027\006\036\027\021\030\026\006\017\036\005 \021\030\024\n\002\017\ \027\026 500)Tj /Span<>> BDC ( )Tj EMC (\204\213 \017)Tj /Span<>> BDC ( )Tj EMC (1000 \204\213, \f\024)Tj 0 Tc 0 Tw (-)Tj 0.02 Tc 0.252 Tw T* (\024\021\r\036\021\f\021\r\036\027\027\024. \200)Tj /Span<>> BDC ( )Tj EMC [(2015 \020\024\007\031 \r\023\036\030\r\t\036 \023\030\036\007\f\021\026\r\ \035\036\027)20( )]TJ 0.219 Tw 0 -1.218 TD (\030\024\f\f\017\005\f\022\017\005 \235\017\002\030\017\027\024\r\t\005 \ \022\035\036\005 \025\030\017\024\235\017\021 \(\215\035\026\n\026-)Tj 0.225 Tw 0 -1.218 TD (\205\230\025)Tj /Span<>> BDC ( )Tj EMC (\227 \217\024\f\f\017\016\), \f\024\007\036\030\032\026\013\017\005 \021\ \030\024\n\002\017\027 \r)Tj /Span<>> BDC ( )Tj EMC (\022\024\035\017\004\036)Tj 0 Tc 0 Tw (-)Tj 0.02 Tc 0.154 Tw 0 -1.218 TD (\f\021\r\036 40 \204\213. \212\030\031\020\024\005 \020\030\031\023\023\024\ \005 \002\017\024\035\024\020\017\004\036\f\022\017\b \n\026\021\036)Tj 0 Tc 0 Tw (-)Tj 0.02 Tc 0.215 Tw 0 -1.218 TD [(\030\017\026\035\024\r, )0.6(\017\f\023\024\035\034\031\036\n\t\b )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 11.234 0 Td [(\035\036\004\036\027\017\017 )0.5(\f\r\017\013\036\005 )0.5(\023\030\016\n\024\005)20( )]TJ 0.33 Tw -11.234 -1.218 Td (\022\017\001\022\017, \016\r\035\016\033\021\f\016 \022\024\035\035\026\020\ \036\027\024\r\t\036 \017)Tj /Span<>> BDC ( )Tj EMC [(\f\017\027\021\036\021\017\004\036\f\022\017\036)20.1( )]TJ 0.249 Tw T* [(\017\n\023\035\026\027\021\t )0.5(\021\026\022\017\036 )0.5(\022\026\022: )0.5(T)47(heSur)-32(gisis\256 )0.5(\(C)13(OOK )0.6(Bio)17(tech,)20( )]TJ 0.137 Tw 0 -1.218 TD [(W)22(est L)-31.9(af)16(a)15(ye)-12(t)-30(te, IN\) \(\217\017\f.)]TJ /Span<>> BDC ( )Tj EMC (1\202\) \023\024\035\031\004\036\027\027\t\005 \017)Tj /Span<>> BDC ( )Tj EMC (\023\024\007)Tj 0 Tc 0 Tw (-)Tj 0.02 Tc 0.113 Tw 0 -1.218 TD (\f\035\017\017\f\021\024\005 \024\002\024\035\024\004\022\017 \021\024\027\ \022\024\005 \022\017\001\022\017 \f\r\017\027\034\017 \017)Tj /Span<>> BDC ( )Tj EMC [(GORE)20( )]TJ 0.019 Tw 0 -1.218 TD [(BIO-A F)-18.9(istul)-16(aPl)35(ug\256 \(W.L.)]TJ /Span<>> BDC ( )Tj EMC [(Gor)-24(e&Asso)-16(c)-24(ia)15(tes, Fl)-16(a)-17(gst)15(af)-56(f,)20( )]TJ 0.134 Tw 0 -1.218 TD [(Ar)-37(izona\) \(\217\017\f.)]TJ /Span<>> BDC ( )Tj EMC (1\207\))Tj /Span<>> BDC ( )Tj EMC (\227 \f\017\027\021\036\021\017\004\036\f\022\017\005 \017\n\023\035\026\ \027\021, \f\024)Tj 0 Tc 0 Tw (-)Tj 0.02 Tc 0.441 Tw 0 -1.218 TD (\f\021\024\016\013\017\005 \017)Tj /Span<>> BDC ( )Tj EMC (\020\035\017\022\024\035\017\007\026 \017)Tj /Span<>> BDC ( )Tj EMC [(\021\030\017\n\036\021\017\035\036\027\022\026\030\002\024\027\026\021\026\ .)20( )]TJ 0.317 Tw 0 -1.218 TD [(\203\026\017\002\024\035\034\001\036\036 )0.5(\030\026\f\023\030\024\f\021\030\026\027\036\027\017\036 )0.6(\f\030\036\007\017 )0.5(\024\021\036\004\036\f\021\r\036\027)]TJ 0 Tc 0 Tw (-)Tj 0.02 Tc 0.354 Tw 0 -1.218 TD [(\027\t\b \022\024\035\035\026\020\036\027\024\r\t\b \017\n\023\035\026\027\ \021\024\r \023\024\035\031\004\017\035 \025\024\035\035\024\f\021\256)20( )]TJ 0.024 Tw 0 -1.218 TD (\(\217\017\f.)Tj /Span<>> BDC ( )Tj EMC (1 \200-\206\), \023\024\035\031\004\026\036\n\t\005 \017)Tj /Span<>> BDC ( )Tj EMC (\022\024\032\017 \002\t\022\026 \017)Tj /Span<>> BDC ( )Tj EMC [(\017\n\036\033\013\017\005)20( )]TJ 0.252 Tw 0 -1.218 TD [(\027\026\021\017\r\027\031\033 \f\021\030\031\022\021\031\030\031 \022\024\ \035\035\026\020\036\027\026, \022\024\021\024\030\026\016 \016\r\035\016\ \036\021\f\016)20( )]TJ 0.113 Tw 0 -1.218 TD (\n\026\021\030\017\006\036\005 \017, \r)Tj /Span<>> BDC ( )Tj EMC (\007\026\035\034\027\036\005\001\036\n, \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\017\n\023\035\026\027\021\026\006\017\017 \007\026\027)Tj 0 Tc 0 Tw (-)Tj 0.02 Tc 0.128 Tw 0 -1.218 TD [(\027\024\020\024 )0.6(\n\026\021\036\030\017\026\035\026 )0.6(\f\024\007\026\036\021 )0.5(\031\f\035\024\r\017\016 )0.5(\007\035\016 )0.5(\030\036\020\036\027\036\030\026\006\017\017)20( )]TJ 0 Tw 0 -1.218 TD (\021\022\026\027\036\005 [46].)Tj 0 Tc 0.049 Tw 0 -1.218 TD (\216\017\030\031\030\020\017\004\036\f\022\024\036 \035\036\004\036\027\017\ \036 \f\r\017\013\036\005 \023\030\016\n\024\005 \022\017\001\022\017 \017\ \n\036\036\021 )Tj -0.016 Tw 0 -1.218 TD (\001\017\030\024\022\017\005 \007\017\026\023\026\024\027 \r\t\002\024\030\ \026 \n\036\021\024\007\024\r. \200)Tj /Span<>> BDC ( )Tj EMC (\007\026\027\027\024\n \024\002\024\030\036 )Tj 0.043 Tw 0 -1.218 TD [(\n\t \030\026\f\f\n\024\021\030\017\n \r\024\n\024\032\027\024\f\021\017\ \023\030\017\n\036\027\036\027\017\016 )0.5(\030\026\035\017\004\027\t\b )]TJ 0.202 Tw 0 -1.218 TD (\002\017\024\023\035\026\f\021\017\004\036\f\022\017\b \n\026\021\036\030\ \017\026\035\024\r \r)Tj /Span<>> BDC ( )Tj EMC (\035\036\004\036\027\017\017 \022\030\017\023\021\024\020\036\027)Tj 0 Tw (-)Tj 0 -1.218 TD (\027\t\b \f\r\017\013\036\005 \023\030\016\n\024\005 \022\017\001\022\017\ .)Tj ET q 42.52 233.364 158.018 119.056 re W n q /GS0 gs 158.018609 0 0 119.1143373 42.5196827 233.3045469 cm /Im0 Do Q Q BT 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0.767 Tw /Span<>> BDC 10 0 0 10 200.5383 233.3638 Tm ( )Tj EMC ET q 211.788 233.364 158.74 119.056 re W n q 158.7401559 0 0 119.1151604 211.7882977 233.3037191 cm /Im1 Do Q Q q 317.0699288 0 0 130.3323161 42.519685 101.0314434 cm /Im2 Do Q BT /T1_3 1 Tf 0 Tw 9 0 0 9 42.5197 90.1701 Tm (\022\t\217\210\b\002\220 1.)Tj 0 0 0 1 k /GS1 gs /T1_4 1 Tf ( \022\b\032 \021\034\027\027\037\013\016\020\034\036\032\002 \022\006\f\ \027\037\020\035\034\036. \205. The)Tj /Span<>> BDC ( )Tj EMC [(Surgisis\256. \210. GORE B)0.5(IO-A Fistula Plug\256. . \022)]TJ /Span<>> BDC ( )Tj EMC (\223. \r\034\027\027\034\024\035\256)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0 -1.2 TD [(F)-16(igure 1)47.1(.)]TJ 0 0 0 1 k /GS1 gs /T1_4 1 Tf [( T)41(ypes of)]TJ /Span<>> BDC ( )Tj EMC [(collag)12.1(en plug. \205. The)]TJ /Span<>> BDC ( )Tj EMC [(Surgisis\256. \210. GORE BIO-A Fistula Pl)0.5(ug\256. . and \223)40(. 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how)12(ev)13(er they show high percentag)12.1(e of)]TJ /Span<>> BDC ( )Tj EMC [(disease recur)-15.9(rence. Consider)-37(ing the)]TJ /Span<>> BDC ( )Tj EMC (safety of)Tj /Span<>> BDC ( )Tj EMC [(the techniq)14(ues, they )]TJ T* (can be used as the)Tj /Span<>> BDC ( )Tj EMC [(f)-43(irst line of)]TJ /Span<>> BDC ( )Tj EMC [(treatment for rectal f)-43(istulas. How)12.1(ev)13(er)61(, it is necessar)-42.9(y to)]TJ /Span<>> BDC ( )Tj EMC (study the)Tj /Span<>> BDC ( )Tj EMC [(r)-37(isk factors of)]TJ /Span<>> BDC ( )Tj EMC [(f)-43(is)]TJ 0 Tw (-)Tj 0.023 Tw 0 -1.111 TD [(tula recur)-15.9(rence and to)]TJ /Span<>> BDC ( )Tj EMC (modify the)Tj /Span<>> BDC ( )Tj EMC (methods according to)Tj /Span<>> BDC ( )Tj EMC (them.)Tj /T1_1 1 Tf 0.01 Tc -0.01 Tw 8 0 0 8 70.9061 665.2226 Tm [(KEYW)22(ORDS:)]TJ /T1_0 1 Tf 0 Tc 0.023 Tw 4.948 0 Td [( rectal f)-43(istula, f)-42.9(istula-in-ano, cr)-43(yp)13(tog)13(landular f)-43(istula, f)-43(ibr)-37(in g)13(lue, collag)12(en im)16(plant, collag)12.1(en plug, f)-43(istula plug)]TJ /T1_1 1 Tf 0.01 Tc 0.018 Tw -4.948 -1.909 Td [(C)19(ONFL)-33(ICT)5( OF)]TJ /Span<>> BDC 5.312 0 Td ( )Tj EMC [(INTE)25(REST)61.9(:)]TJ /T1_0 1 Tf 0 Tc 0.023 Tw 4.559 0 Td ( the)Tj /Span<>> BDC ( )Tj EMC [(authors declare no conf)-22(lict of)]TJ /Span<>> BDC ( )Tj EMC (interest)Tj /T1_1 1 Tf 0.037 Tc 0.02 Tw -9.871 -2.617 Td [(F)3.2(O)-4.6(R)8.7( C)-17.4(I)-15.6(T)45.4(A)37.5(T)-24.5(I)-1.2(ON:)]TJ /T1_2 1 Tf 0.023 Tc 0.029 Tw 6.465 0 Td [( L)-41.1(a)-27.5(z)-27.5(a)-10.2(r)-19.1(e)-15.8(v)]TJ /Span<>> BDC ( )Tj EMC [(K)-27(.)-23.9(A)-23(.)-23.5(, V)-25.2(y)-28.9(s)-8.8(h)-15.1(e)-21(g)-10.1(o)-11.9(r)-15.8(o)-20.4(d)-9.3(c)-9.7(e)-15.8(v)]TJ /Span<>> BDC ( )Tj EMC [(D)16.4(.)40.6(V)39.7(.)-23.4(, B)-14.9(o)-18.6(g)-10.2(o)-11.8(r)-35.9(m)-14.5(i)-7.4(s)-29.2(t)-30.8(r)-15.8(o)-10.3(v)]TJ /Span<>> BDC ( )Tj EMC [(I)-10.3(.)-26.9(S)-9.6(.)-23.5(, K)-11.2(o)-11.8(r)-15.8(o)-15.6(l)-16.7(i)-6.6(k V)39.7(.)51.6(Y)12.6(u)-9(. F)-29(i)-5.9(b)-13.8(r)-56.4(i)-3.2(n g)-11.8(l)-23.3(u)-12.5(e a)-7.6(n)-14.5(d b)-19.5(i)-6.8(o)-8.3(p)-20.1(l)-37.8(a)-26.6(s)-29.3(t)-46.2(i)-5(c i)-3.2(m)-5.2(p)-20.1(l)-37.8(a)-7.6(n)-17.3(t)-48.9(s i)-3.2(n t)-30.8(r)-19.1(e)-12.9(a)-18.3(t)-26(m)-16.6(e)-11.5(n)-17.3(t)23( )]TJ 0.02 Tc -0.035 Tw -6.47 -1.2 Td [(o)-12.1(f)]TJ /Span<>> BDC ( )Tj EMC [(r)-19.1(e)-19.1(c)-41.4(t)-36.8(a)-11.4(l f)-63(i)-7.3(s)-29.3(t)-22.3(u)-8.3(l)-37.8(a)-26.6(s \()39.2(r)-19.1(e)-15.7(v)-51.8(i)-10.9(e)-12.5(w)19.7(\))10.4(. )]TJ /T1_0 1 Tf 0.03 Tc -0.03 Tw [(K)13.9(ol)3.6(op)2.5(r)3.1(o)3.5(k)-19.2(t)2.2(ol)3.6(o)-3.3(g)-13.1(i)6.7(a)5.8(.)]TJ /T1_2 1 Tf 0.02 Tc -0.035 Tw 18.43 0 Td [( 2)-8.9(0)-3.8(2)-1.3(5)23.3(;)9.8(2)8.9(4)-13.5(\()40.1(4)30.4(\))14.5(:)21(1)12.6(6)1.8(7)35.7(\226)50.9(1)24.2(7)28.9(6)5.1(. \()-0.9(i)-3.1(n R)-6.5(u)-21.8(s)-22.3(s)-15.5(.)43.3(\))10.4(. h)-17.1(t)-49.4(t)-29.4(p)-18.6(s)-8(:)2(/)84.7(/)36.4(d)-11(o)-12.5(i.)2.8(o)-11.8(r)-16.6(g)-22.8(/)11.2(1)14(0)6.6(.)-5.6(3)8(3)-15.9(8)1.3(7)4.6(8/)7.9(2)-8.9(0)9.4(7)-1.9(3)-13.3(-)41.3(7)10.7(55)-8.8(6)-26.7(-)9.7(2)-8.8(0)-3.8(2)-1.4(5)-23.4(-)9.7(2)8.8(4)-28.4(-)-30.3(4)-28.5(-)55.2(1)12.6(6)1.8(7)36.3(-)55.1(1)24.2(7)29(6)]TJ /T1_1 1 Tf 0.01 Tc 0.034 Tw -18.425 -2.617 Td [(\021\024\027\030\026)5( \024\033\023)5( \t\030\027\030\t\032\026\037\032:)]TJ /T1_0 1 Tf 0 Tc 0.039 Tw 10.61 0 Td ( \231\037\031\037\033\016\036 \r\022\033\022\027\027 \205\027\016\021\024\ \016\016\036\022\005, \216\223\210\215 \253\217\214\200\221 \021\034\027\ \034\f\033\034\021\035\034\027\034\013\022\022 \022\006\016\020\022 \205\ .\217.)Tj /Span<>> BDC ( )Tj EMC (\213\032\201\022\002\273 \214\022\020\031\b\033\037\036\037 \213\034\024\ \024\022\022, \023\027.)Tj /Span<>> BDC ( )Tj EMC (\207\037\027\030\006\037 )Tj 0.023 Tw -10.615 -1.2 Td (\205\b\022\027\030, \b.)Tj /Span<>> BDC ( )Tj EMC (2, \214\034\024\021\036\037, 123423, \213\034\024\024\022\030; e-mail: l\ azarev.k1996@rambler.ru)Tj /T1_1 1 Tf 0.01 Tc 0.031 Tw 0.005 -1.2 Td [(ADDRESS)4.9( F)13(OR)5( C)19(ORRESPONDEN)23(CE:)]TJ /T1_0 1 Tf 0 Tc 0.036 Tw 14.077 0 Td [( Kir)-37(ill A. Lazarev)63(, Ryzhikh N)18(ational Medical R)21(esearch Center of)]TJ /Span<>> BDC ( )Tj EMC [(Colop)46.1(roctology)42(, Salyama Adilya st., 2, Moscow)52(, )]TJ 0.023 Tw -14.082 -1.2 Td [(123423, R)22(ussia; e-mail: lazarev)53(.k1996@rambler)51.1(.ru)]TJ 0 Tw 0 -2.792 TD (\n\037\035\037 \f\034\024\035\023\f\027\016\020\022\030)Tj /Span<>> BDC ( )Tj EMC (\227 22.05.2025)Tj /Span<>> BDC ( )Tj EMC 19.488 0 Td (\t\034\024\027\016 \b\034\033\037\025\034\035\021\022)Tj /Span<>> BDC ( )Tj EMC (\227 04.09.2025)Tj /Span<>> BDC ( )Tj EMC 18.78 0 Td (\t\033\022\020\030\035\034 \021)Tj /Span<>> BDC ( )Tj EMC (\f\023\025\027\022\021\037\007\022\022)Tj /Span<>> BDC ( )Tj EMC (\227 10.11.2025)Tj ( )Tj -38.268 -1.375 Td (Received)Tj /Span<>> BDC ( )Tj EMC (\227 22.05.2025)Tj /Span<>> BDC ( )Tj EMC 19.488 0 Td (Revised)Tj /Span<>> BDC ( )Tj EMC (\227 04.09.2025)Tj /Span<>> BDC ( )Tj EMC 18.78 0 Td (Accepted for publication)Tj /Span<>> BDC ( )Tj EMC (\227 10.11.2025)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 70.936 493.4479 Tm (\023\023\034\226\034\022\031\034)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf 0.016 Tc 0.139 Tw 10 0 0 10 70.8661 469.0919 Tm (\224\r\017\013 \023\030\016\n\024\005 \022\017\001\022\017)Tj /Span<>> BDC ( )Tj EMC [(\227 \b\030\024\027\017\004\036\f\022\024\036 \026\002\024\035\036\r\026\ \027\017\036,)16( )]TJ 0.11 Tw 0 -1.218 TD (\f\r\016\026\027\027\024\036 \f)Tj /Span<>> BDC ( )Tj EMC (\r\024\f\023\026\035\036\027\017\036\n \032\036\035\036\t \026\027\026\035\ \034\027\024\020\024 \022\026\027\026)Tj 0 Tc 0 Tw (-)Tj 0.016 Tc 0.123 Tw T* (\035\026, \024\022\024\035\024\023\030\016\n\024\022\017\001\036\004\027\ \024\005 \022\035\036\021\004\026\021\022\017, \f)Tj /Span<>> BDC ( )Tj EMC (\235\024\030\n\017\030\024\r\026)Tj 0 Tc 0 Tw (-)Tj 0.016 Tc 0.283 Tw T* [(\027\017\036\n \f\r\017\013\036\r\024\020\024 \b\024\007\026, \f\r\016\t\ \r\026\033\013\036\020\024 \r\027\031\021\030\036\027\027\036\036)16( )]TJ 0.07 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\027\026\030\031\032\027\024\036 \f\r\017\013\036\r\t\036 \024\021\r\036\ \030\f\021\017\016. \200\027\031\021\030\036\027\027\017\n \f\r\017)Tj 0 Tc 0 Tw (-)Tj 0.016 Tc 0.31 Tw T* [(\013\036\r\t\n \024\021\r\036\030\f\021\017\036\n \016\r\035\016\036\021\ \f\016 \r\024\f\023\026\035\036\027\027\026\016 \022\030\017\023\021\026\ )16( )]TJ 0.034 Tw T* [(\026\027\026\035\034\027\024\020\024 )0.5(\022\026\027\026\035\026, )0.5(\023\024\007 )0.6(\021\026\022\017\n\017 )0.5(\f\r\017\013\026\n\017 )0.5(\023\024\007\030\026\031\n\036)]TJ 0 Tc 0 Tw (-)Tj 0.016 Tc 0.211 Tw T* [(\r\026\033\021 \f\r\017\013\017 \022\030\017\023\021\024\020\035\026\027\ \007\031\035\016\030\027\024\020\024 \023\030\024\017\f\b\024\032\007\036\ \027\017\016)16( )]TJ -0.016 Tw T* ([1\2262].)Tj 0 Tc 0.14 Tw T* [(\003\026\002\024\035\036\r\026\036\n\024\f\021\034 \f\r\017\013\026\n\017\ )0.5(\023\030\016\n\024\005 \022\017\001\022\017 \f\024\f\021\026\r\035\016\036\ \021, )373.1( )]TJ -0.053 Tw T* (\023\024)Tj /Span<>> BDC ( )Tj EMC (\030\026\035\017\004\027\t\n \007\026\027\027\t\n, \024\021 12 \007\024\ )Tj /Span<>> BDC ( )Tj EMC (28 \f\035\031\004\026\036\r \027\026)Tj /Span<>> BDC ( )Tj EMC (1000)Tj /Span<>> BDC ( )Tj EMC (\027\026)Tj 0 Tw (-)Tj -0.038 Tw T* (\f\036\035\036\027\017\016 [2]. \203\026\017\002\024\035\036\036 \004\026\ \f\021\024 \007\026\027\027\026\016 \027\024\024\035\024\020\017\016 \r\ \f\021\030\036)Tj 0 Tw (-)Tj 0.143 Tw T* (\004\026\036\021\f\016 \r)Tj /Span<>> BDC ( )Tj EMC (\r\024\030\026\f\021\036 20\22650 \035\036\021, \n\031\032\004\017\027\t\ \023\024\007\r\036\030\032\036\027\t )Tj 0.028 Tw T* (\007\026\027\027\024\n\031 \026\002\024\035\036\r\026\027\017\033 \004\026\ \013\036, \004\036\n \032\036\027\013\017\027\t, \r)Tj /Span<>> BDC ( )Tj EMC (\f\024\024\021\027\024)Tj 0 Tw (-)Tj T* (\001\036\027\017\017 2:1 [5\2269].)Tj 0.301 Tw T* (\224\031\013\036\f\021\r\031\036\021 \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\017\n\036\027\016\036\021\f\016 \r)Tj /Span<>> BDC ( )Tj EMC (\022\035\017\027\017\004\036\f\022\024\005 \023\030\026\022\021\017)Tj 0 Tw (-)Tj 0.171 Tw T* (\022\036 \027\036\f\022\024\035\034\022\024 \022\035\026\f\f\017\235\017\ \022\026\006\017\005 \022\030\017\023\021\024\020\036\027\027\t\b \f\r\017\ \013\036\005 )Tj 0.023 Tw T* (\023\030\016\n\024\005 \022\017\001\022\017. \203\026\017\002\024\035\036\ \036 \001\017\030\024\022\024 \r)Tj /Span<>> BDC ( )Tj EMC (\027\026\001\036\005 \f\021\030\026\027\036 \017\f)Tj 0 Tw (-)Tj 0.141 Tw T* (\023\024\035\034\031\036\021\f\016 \030\026\030\026\002\024\021\026\027\ \027\026\016 \r)Tj /Span<>> BDC ( )Tj EMC (1956 \020\024\007\031 \022\035\026\f\f\017\235\017\022\026)Tj 0 Tw (-)Tj T* (\006\017\016 \202.\203.)Tj /Span<>> BDC ( )Tj EMC (\217\t\032\017\b:)Tj 0.3 Tw T* (\226)Tj /Span<>> BDC [( )33( )]TJ EMC 1.056 0 Td (\017\027\021\030\026\f\235\017\027\022\021\036\030\027\t\036 \(\f\r\017\013\ \023\030\024\b\024\007\017\021 \r)Tj /Span<>> BDC ( )Tj EMC (\023\024\007\f\035\017\017)Tj 0 Tw (-)Tj T* (\f\021\024\n \f\035\024\036\);)Tj 0.061 Tw -1.056 -1.218 Td (\226)Tj /Span<>> BDC [( )-206( )]TJ EMC 1.056 0 Td [(\021\030\026\027\f\f\235\017\027\022\021\036\030\027\t\036 )0.5(\(\f\r\017\013 \023\030\024\b\024\007\017\021 \004\036\030\036 \f\021\030\ \031\022\021\031)]TJ 0 Tw (-)Tj T* (\030\t \026\027\026\035\034\027\024\020\024 \032\024\n\026\);)Tj -1.056 -1.218 Td (\226)Tj /Span<>> BDC [( )-267( )]TJ EMC 1.056 0 Td (\220\022\f\021\030\026\f\235\017\027\022\021\036\030\027\t\036 \(\f\r\017\ \013 \024\020\017\002\026\036\021 \f\235\017\027\022\021\036\030\) [3].)Tj 0.006 Tw -1.056 -1.218 Td [(\200 1976 \020. P)40(ar)-24(k)-9.9(s \202. e)-12(t al. \023\030\036\007\035\024\032\017\035 \f\r\024\033 \022\035\026\f\f\ \017\235\017\022\026)]TJ 0 Tw (-)Tj T* (\006\017\033 \f\r\017\013\036\005 \023\030\016\n\024\005 \022\017\001\022\ \017:)Tj 1.193 Tw T* (\226)Tj /Span<>> BDC [( )926( )]TJ EMC 1.056 0 Td (\n\036\032\f\235\017\027\022\021\036\030\027\t\036 \(\f\r\017\013\017, \023\ \030\024\b\024\007\016\013\017\036 \004\036)Tj 0 Tw (-)Tj 0.589 Tw T* (\030\036 \r\027\031\021\030\036\027\027\017\005 \f\235\017\027\022\021\036\ \030 \r)Tj /Span<>> BDC ( )Tj EMC (\n\036\032\f\235\017\027\022\021\036\030\027\024\036 )Tj 0 Tw T* (\023\030\024\f\021\030\026\027\f\021\r\024\);)Tj 0.549 Tw -1.056 -1.218 Td (\226)Tj /Span<>> BDC [( )282( )]TJ EMC 1.056 0 Td (\021\030\026\027\f\f\235\017\027\022\021\036\030\027\t\036 \f\r\017\013\017\ \(\f\r\017\013\017, \023\030\024\b\024\007\016\013\017\036 )Tj 0.341 Tw T* [(\004\036\030\036 )0.5(\027\017\032\027\033\033 )0.6(\004\026\f\021\034 )0.6(\r\027\031\021\030\036\027\027\036\020\024 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 16.594 0 Td (\027\026\030\031\032\027\024\020\024 )Tj 0 Tw -16.594 -1.218 Td (\f\235\017\027\022\021\036\030\024\r \r)Tj /Span<>> BDC ( )Tj EMC (\017\001\017\024\030\036\022\021\026\035\034\027\031\033 \022\035\036\021\ \004\026\021\022\031\).)Tj 0.217 Tw 22.188 41.405 Td (\215\024)Tj /Span<>> BDC ( )Tj EMC (\024\021\027\024\001\036\027\017\033 \022)Tj /Span<>> BDC ( )Tj EMC (\031\002\004\026\021\024\005 \035\017\027\017\017 \021\030\026\027\f\f\235\ \017\022\021\036\030\027\t\036 )Tj 0 Tw T* (\f\r\017\013\017 \007\036\035\016\021 \027\026:)Tj -0.233 Tw T* (\226)Tj /Span<>> BDC [( )-500( )]TJ EMC (\r\t\f\024\022\017\036;)Tj T* (\226)Tj /Span<>> BDC [( )-500( )]TJ EMC (\027\017\022\017\036;)Tj 0.628 Tw T* (\226)Tj /Span<>> BDC [( )361( )]TJ EMC 1.056 0 Td (\f\031\023\030\026\f\235\017\027\022\021\036\030\027\t\036 \(\f\r\017\013\ \017, \023\030\024\b\024\007\016\013\017\036 \004\036\030\036 )Tj 0.45 Tw T* [(\r\036\030\b\027\033\033 )0.6(\004\026\f\021\034 )0.5(\n\036\032\f\235\017\027\022\021\036\030\027\024\020\024 )0.6(\023\030\024\f\021\030\026\027\f\021\r\026 )]TJ 0.103 Tw T* (\027\026\007 \035\024\002\022\024\r\024-\023\030\016\n\024\022\017\001\036\ \004\027\024\005 \n\t\001\006\036\005 \r)Tj /Span<>> BDC ( )Tj EMC (\017\001\017\024\030\036\022)Tj 0 Tw (-)Tj T* (\021\026\035\034\027\031\033 \016\n\022\031\);)Tj 0.515 Tw -1.056 -1.218 Td (\226)Tj /Span<>> BDC [( )248( )]TJ EMC 1.056 0 Td (\220\022\f\021\030\026\f\235\017\027\022\021\036\030\027\t\036 \(\f\r\017\ \013\017, \023\030\024\b\024\007\016\013\017\036 \004\036\030\036 )Tj -0.042 Tw T* [(\n\t\001\006\031, \023\024\007\027\017\n\026\033\013\031\033 \026\007\027\ \017\005 )0.5(\023\030\024\b\024\007 \022)]TJ /Span<>> BDC ( )Tj EMC [(\f\021\036\027\022\036 )0.5(\023\030\016)]TJ 0 Tw (-)Tj T* (\n\024\005 \022\017\001\022\017 \r\027\036 \f\235\017\027\022\021\036\030\ \027\024\020\024 \026\023\023\026\030\026\021\026\) [4].)Tj 0.03 Tc 0.63 Tw -1.056 -1.218 Td [(\213\007\017\027\f\021\r\036\027\027\t\n )0.5(\030\026\007\017\022\026\035\034\027\t\n )0.5(\n\036\021\024\007\024\n )0.6(\035\036\004\036\027\017\016)30( )]TJ 0.354 Tw T* [(\f\r\017\013\036\005 \023\030\016\n\024\005 \022\017\001\022\017 \016\r\035\ \016\036\021\f\016 \b\017\030\031\030\020\017\004\036\f\022\024\036)30( )]TJ 0.385 Tw T* (\035\036\004\036\027\017\036, \027\026\023\030\026\r\035\036\027\027\024\ \036 \027\026)Tj /Span<>> BDC ( )Tj EMC (\035\017\022\r\017\007\026\006\017\033 \f\r\017\013\036)Tj 0 Tc 0 Tw (-)Tj 0.03 Tc 0.238 Tw T* (\r\024\020\024 \b\024\007\026, \r\027\031\021\030\036\027\027\036\020\024\ \017)Tj /Span<>> BDC ( )Tj EMC [(\027\026\030\031\032\027\024\020\024 \f\r\017\013\036\r\024\020\024)30( )]TJ -0.03 Tw T* (\024\021\r\036\030\f\021\017\016.)Tj 0.416 Tw T* [(\212\035\016 \f\024\b\030\026\027\036\027\017\016 \235\031\027\022\006\017\ \017 \026\027\026\035\034\027\024\020\024 \007\036\030\032\026\027\017\016\ )30( )]TJ 0.681 Tw T* (\023\030\017\n\036\027\016\033\021\f\016 \030\026\035\017\004\027\t\036\ \n\036\021\024\007\t \n\026\035\024\021\030\026\r\n\026)Tj 0 Tc 0 Tw (-)Tj 0.03 Tc 0.235 Tw T* (\021\017\004\027\024\020\024 \r\024\007\036\005\f\021\r\017\016 \027\026\ )Tj /Span<>> BDC ( )Tj EMC (\220\023\017\021\036\035\017\026\035\034\027\031\033 \r\t\f\021\017\035)Tj 0 Tc 0 Tw (-)Tj 0.03 Tc 0.446 Tw T* [(\022\031 \f\r\017\013\036\r\024\020\024 \b\024\007\026, \022\024\021\024\ \030\t\036 \027\036 \r\024\007\036\005\f\021\r\031\033\021)30( )]TJ 0.149 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC (\n\t\001\036\004\027\t\036 \f\021\030\031\022\021\031\030\t \026\023\017\ \030\026\021\036\035\034\027\024\020\024 \026\023\023\026\030\026)Tj 0 Tc 0 Tw (-)Tj 0.03 Tc 0.068 Tw T* (\021\026 \023\030\016\n\024\005 \022\017\001\022\017. \025)Tj /Span<>> BDC ( )Tj EMC [(\027\017\n \024\021\027\024\f\016\021\f\016: F)-19(iL)-32(aC \(F)-19(istul)-16(a)30( )]TJ 0.435 Tw T* [(L)-32(aser Coa)-17(gul)-16(a)15(t)-31.9(ion\), V)37(AAFT \(V)-15(ideo-Assisted Anal)30( )]TJ 0.403 Tw T* [(F)-19(istul)-16(a T)50(r)-24(ea)15(tment\), PRP \(Pl)-16(a)15(tele)-11.9(t R)-23.9(ich Pl)-16(as)26(ma\),)30( )]TJ 0.395 Tw T* [(S)-13(VF \(S)15(tr)-32(omal V)25.1(ascul)-16(ar F)10(r)-33(a)-17(c)-16(t)-32(ion\), LIFT \(L)-32(iga)15(t)-32(ion)30( )]TJ 0.116 Tw T* (of)Tj /Span<>> BDC ( )Tj EMC [(Inter)-9.9(sphinc)-16(ter)-37(ic F)-19(istul)-15.9(a T)50(r)-33(a)-17(c)-16(t\). \210\007\027\026\022\024 \220\021\017 \n\036)]TJ 0 Tc 0 Tw (-)Tj 0.03 Tc 0.301 Tw T* [(\021\024\007\t \f\024\023\030\024\r\024\032\007\026\033\021\f\016 )0.5(\r\t\f\024\022\017\n \023\030\024\006\036\027\021\024\n \030\026)]TJ 0 Tc 0 Tw (-)Tj 0.03 Tc 0.24 Tw T* (\r\017\021\017\016 \030\036\006\017\007\017\r\026 \026\002\024\035\036\r\ \026\027\017\016 \(\024\021 30% \007\024)Tj /Span<>> BDC ( )Tj EMC [(70%\).)30( )]TJ -0.035 Tw T* (\025)Tj /Span<>> BDC ( )Tj EMC (\f\235\017\027\022\021\036\030\024\f\002\036\030\036\020\026\033\013\017\ \n \n\036\021\024\007\017\022\026\n \n\024\032\027\024 \024\021\027\036)Tj 0 Tc 0 Tw (-)Tj 0.03 Tc -0.036 Tw T* (\f\021\017 \017)Tj /Span<>> BDC ( )Tj EMC (\n\026\035\024\017\027\r\026\017\r\027\t\036 \n\036\021\024\007\t \035\036\ \004\036\027\017\016 \f)Tj /Span<>> BDC ( )Tj EMC (\023\030\017\n\036\027\036)Tj 0 Tc 0 Tw (-)Tj 0.03 Tc 0.059 Tw T* [(\027\017\036\n \002\017\024\023\035\026\f\021\017\004\036\f\022\017\b )0.5(\n\026\021\036\030\017\026\035\024\r. \230\026\022, )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC (1991)Tj /Span<>> BDC ( )Tj EMC [(\020.)30( )]TJ 0.068 Tw T* (\023\030\036\007\035\024\032\036\027\024 \023\030\017\n\036\027\036\027\017\ \036 \235\017\002\030\017\027\024\r\024\020\024 \022\035\036\016 \r)Tj /Span<>> BDC ( )Tj EMC (\035\036)Tj 0 Tc 0 Tw (-)Tj 0.03 Tc 0.048 Tw T* [(\004\036\027\017\017 )0.5(\f\r\017\013\036\005 )0.5(\023\030\016\n\024\005 )0.5(\022\017\001\022\017, \026)]TJ /Span<>> BDC ( )Tj EMC 14.188 0 Td [(\r 2006 )0.5(\020\024\007\031 )0.5(\023\030\036\007)]TJ 0 Tc 0 Tw (-)Tj 0.03 Tc 0.103 Tw -14.188 -1.218 Td (\035\024\032\036\027\024 \023\030\017\n\036\027\036\027\017\036 \002\017\ \024\023\035\026\f\021\017\004\036\f\022\017\b \022\024\035\035\026\020\036\ \027\024)Tj 0 Tc 0 Tw (-)Tj 0.03 Tc T* (\r\t\b \017\n\023\035\026\027\021\026\021\024\r [10\22616,45,47].)Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 0 Tc 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\206)10(\002\036\033 \035\030\032\003\033)30(\n)42(\032)-21(\230\033\241)]TJ 57.136 0 Td (REVIEW)Tj -57.136 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 2)69(4, \023\0224, 202)23(5)]TJ 43.013 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 2)69(4, \023\0224, 202)23(5)]TJ /T1_5 1 Tf 25 0 0 25 20.8026 56.0378 Tm (168)Tj ET endstream endobj 1187 0 obj [1200 0 R] endobj 1188 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\034\201\021\024\016\215\016\215\021\016 \223\021\235\201\021\215\025\r\025\ \202)10(\025 \017)-10(\t\016\004 \021\022\235\021\025\222\t\001\b)-10(\026\021\f\016\b\017\021 \021\024\222\t\001\215\026)11(\025\r )]TJ 0 -1 TD [(\r\022\t\016\f\016\215\021\021 \b\r\021\232\016\207 \222\201\004\024\025\ \207 \017\021\020\017\021 \(\025\235\213\025\201\022\t\021\026)11(\016\201\001\026)-19.9(\200\201\220\))]TJ 32.168 1 Td [(Fibrin glue and bioplastic implants in tr)31(eatment of\022r)31(ectal f)-21(istulas \(r)31(e)11(vie)11(w\))]TJ ET 0 0 0 1 K 1 j 1 J [0 2.997]0 d /GS1 gs q 1 0 0 1 46.0167 331.0103 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 43.0197 331.0103 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q [0 2.997]0 d q 1 0 0 1 46.0167 293.8025 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 43.0197 293.8025 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q BT 0 0 0 1 k /T1_1 1 Tf 10 0 0 10 42.5197 724.8299 Tm (https://doi.org/10.33878/2073-7556-2025-24-4-167-176)Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 0.023 Tw 19 0 0 19 66.705 695.3259 Tm [(\034\201\021\024\016\215\016\215\021\016 \223\021\235\201\021\215\025\r\025\ \202)10(\025 \017)-9.9(\t\016\004 \021\022)-23.3(\235\021\025\222\t\001\b)-10(\026\021\f\016\b\017\021 )]TJ 1.535 -1.105 Td [(\021\024\222\t\001\215\026)11.1(\025\r \r\022)-23.3(\t\016\f\016\215\021\021 \b\r\021\232\016\207 \222\201\004\024\025\207 \017\ \021\020\017\021 )]TJ 0 Tw 4.973 -1.105 Td [(\(\025\235\213\025\201\022)-23.3(\t\021\026)11(\016\201\001\026)-20(\200\201\220\))]TJ 0 0 0 1 k /GS1 gs 0.023 Tw 14 0 0 14 42.5197 628.822 Tm [(\035\001\213\001\201\016\r\022)-23.2(\037.\n)-31(., \006\220\020\016\202)10(\025\201\025\211\212\016\r\022)-23.2(\240.\006., \206\025\202)10(\025\201\024\021\b)-9.9(\026\201\025\r\022)-23.3(\030.\013., \037)31(\025\201\025\t\021\017\022)-23.2(\006.\204.)]TJ 10 0 0 10 42.5197 611.1527 Tm [(\203\031\206)42(\230 \253\217\007\030\226 \017)10(\025\t\025\222\201\025\017)-9.9(\026)11(\025\t\025\202\021\021 \021\024\016\215\021 \n)-30.9(.\217.\022)-23.3(\033\220\216\021\273 \007\021\215\213\211\201\001\r\001 \033\025\b\b\021\ \021 \(\200\t.\022)-23.2(\013\001\t\004\024\001 \n)-20.9(\211\021\t\004, \211.\022)-23.3(2, )]TJ 0 -1.2 TD [(\202)62(.\022)-23.3(\007\025\b\017\r\001,1)125(23)58(423, \033\025\b\b\021\004\))]TJ /T1_1 1 Tf 0.214 Tw 9 0 0 9 90.7087 580.6488 Tm [(\204\n\204\217\200\204: \b\027\030 )0.5(\027\016\005\016\020\022\030 \024\036\022\235\016\004 )0.5(\f\033\030\006\034\004 )0.5(\021\022\001\021\022 \022\024\f\034\027\003\031\023\026\035\024\030 )0.5(\033\037\031\027\022\005\020\032\016 \002\022\033\023\033\013\022\005\016\ \024\021\022\016 \006\016\035\034\b\032, \034\b\020\037\021\034 )]TJ 0.09 Tw 0 -1.111 TD (\036\024\016 \034\020\022 \020\016 \022\024\021\027\026\005\037\026\035 \ \035\033\037\036\006\037\035\022\005\016\024\021\034\013\034 \036\034\031\ \b\016\004\024\035\036\022\030 \020\037)Tj /Span<>> BDC ( )Tj EMC (\024\035\033\023\021\035\023\033\032 \037\020\037\027\003\020\034\013\034\ \201\034\006\037. \240\b\020\022\006 \022\031)Tj /Span<>> BDC ( )Tj EMC (\020\037\022\025\034\027\016\016 )Tj 0.19 Tw T* [(\024\016\033\003\016\031\020\032\002 )0.5(\034\024\027\034\201\020\016\020\022\004 )0.5(\030\036\027\030\016\035\024\030 )0.5(\033\037\031\036\022\035\022\016 )0.5(\f\034\024\027\016\034\f\016\033\037\007\022\034\020\020\034\004 )0.5(\020\016\b\034\024\035\037\035\034\005\020\034\024\035\022 \037\020\037\027\ \003\020\034\013\034 )0.5(\024\017\022\020\021\035\016\033\037. )]TJ 0.167 Tw T* (\240\b\020\037\021\034 \f\033\022\006\016\020\016\020\022\016 \033\037\031\ \027\022\005\020\032\002 \025\022\034\006\037\035\016\033\022\037\027\034\ \036 \036\020\034\024\022\035 \034\f\033\016\b\016\027\016\020\020\032\004\ \036\021\027\037\b \036)Tj /Span<>> BDC ( )Tj EMC (\033\037\031\036\022\035\022\016 \006\037\027\034\022\020\036\037\031\022\ \036\020\032\002 )Tj 0.023 Tw T* (\034\f\016\033\037\007\022\004, \020\016 \034\021\037\031\032\036\037\026\ \235\022\002 \034\035\033\022\007\037\035\016\027\003\020\034\013\034 \036\ \034\031\b\016\004\024\035\036\022\030 \020\037)Tj /Span<>> BDC ( )Tj EMC (\031\037\f\022\033\037\035\016\027\003\020\032\004 \037\f\f\037\033\037\035\ \f\033\030\006\034\004 \021\022\001\021\022.)Tj 0.144 Tw 0 -1.111 TD (\221\204\231\232: \034\007\016\020\022\035\003 \220\017\017\016\021\035\022\ \036\020\034\024\035\003 \f\033\022\006\016\020\016\020\022\030 \017\022\ \025\033\022\020\034\036\034\013\034 \021\027\016\030 \022)Tj /Span<>> BDC ( )Tj EMC (\025\022\034\f\027\037\024\035\022\005\016\024\021\022\002 \022\006\f\027\ \037\020\035\034\036 \036)Tj /Span<>> BDC ( )Tj EMC (\027\016\005\016\020\022\022 )Tj 0.023 Tw 0 -1.111 TD (\024\036\022\235\016\004 \f\033\030\006\034\004 \021\022\001\021\022.)Tj -0.025 Tw T* (\t\205\221\200\204\217\202\233 \200)Tj /Span<>> BDC ( )Tj EMC (\214\204\202\240\n\233: \b\027\030 \f\034\b\013\034\035\034\036\021\022 \ \034\025\031\034\033\037 \025\032\027 \f\033\034\022\031\036\016\b\016\020\ \f\034\022\024\021 \027\022\035\016\033\037\035\023\033\032 \036)Tj /Span<>> BDC ( )Tj EMC (\020\037\023\021\034\006\016\035\033\022\005\016\024\021\022\002 \025\037\ \031\037\002 )Tj 0.011 Tw T* [(\b\037\020\020\032\002 )0.5(PubMed, eLibrary )0.5(\022)]TJ /Span<>> BDC ( )Tj EMC [(Kohrane. )0.5(\210\032\027\034 )0.5(\020\037\004\b\016\020\034 842 \024\035\037\035\003\022 )0.5(\f\034)]TJ /Span<>> BDC ( )Tj EMC (\f\033\022\006\016\020\016\020\022\026 \025\022\034\f\027\037\024\035\022\ \005\016\024\021\022\002 \006\037\035\016\033\022\037\027\034\036 )Tj 0.016 Tw T* (\022)Tj /Span<>> BDC ( )Tj EMC (\017\022\025\033\022\020\034\036\034\013\034 \021\027\016\030 \036)Tj /Span<>> BDC ( )Tj EMC (\027\016\005\016\020\022\022 \024\036\022\235\016\004 \f\033\030\006\034\ \004 \021\022\001\021\022. \240\035\025\034\033 \024\035\037\035\016\004\ \f\033\034\022\024\002\034\b\022\027 \f\034)Tj /Span<>> BDC ( )Tj EMC (\024\027\016\b\023\026\235\022\006 \021\033\022\035\016\033\022\030\006:\ )Tj 0.062 Tw T* (\024\035\033\023\021\035\023\033\022\033\034\036\037\020\020\034\024\035\ \003, \027\034\013\022\005\020\034\024\035\003, \037\021\035\023\037\027\ \003\020\034\024\035\003 \022)Tj /Span<>> BDC ( )Tj EMC (\b\034\021\037\031\037\035\016\027\003\020\034\024\035\003 \(\020\037\027\ \022\005\022\016 \f\034\b\035\036\016\033\201\b\037\026\235\022\002 \017\ \037\021\035\032 )Tj 0.061 Tw 0 -1.111 TD (\024\024\032\027\034\021 \020\037)Tj /Span<>> BDC ( )Tj EMC (\034\033\022\013\022\020\037\027\003\020\032\016 \022\024\024\027\016\b\034\ \036\037\020\022\030\) \035\016\021\024\035\037, \022\020\017\034\033\006\ \037\007\022\030 \034)Tj /Span<>> BDC ( )Tj EMC (\035\016\006\037\035\022\021\016 \f\023\025\027\022\021\037\007\022\004 \ \037\036\035\034\033\037, \021\034\027\022\005\016\024\035\036\034 )Tj 0.047 Tw 0 -1.111 TD (\007\022\035\022\033\034\036\037\020\022\004 \024\035\037\035\016\004. \t\ \037\033\037\006\016\035\033\034\006 \022\024\021\027\026\005\016\020\022\ \030 \025\032\027\022 \024\036\022\235\022, \037\024\024\034\007\022\022\ \033\034\036\037\020\020\032\016 \024)Tj /Span<>> BDC ( )Tj EMC (\036\034\024\f\037\027\022\035\016\027\003\020\032\006\022 \031\037\025\034\ \027\016)Tj 0 Tw (-)Tj 0.046 Tw T* (\036\037\020\022\030\006\022 \021\022\001\016\005\020\022\021\037, \f\034\ \024\035\035\033\037\036\006\037\035\022\005\016\024\021\022\016 \022)Tj /Span<>> BDC ( )Tj EMC (\f\034\024\035\027\023\005\016\036\032\016. \t\034\024\027\016 \037\020\037\ \027\022\031\037 \035\016\021\024\035\037 \024\035\037\035\016\004, \025\ \032\027\034 \034\035\034\025\033\037\020\034 )Tj 0.023 Tw T* (20 \024\035\037\035\016\004, \022\031)Tj /Span<>> BDC ( )Tj EMC (\020\022\002 19 \037\020\013\027\034\030\031\032\005\020\032\002 \022)Tj /Span<>> BDC ( )Tj EMC (1 \024\035\037\035\003\030 \033\023\024\024\021\034\030\031\032\005\020\037\ \030 \036)Tj /Span<>> BDC ( )Tj EMC (\f\016\033\022\034\b \024)Tj /Span<>> BDC ( )Tj EMC (2009 \f\034)Tj /Span<>> BDC ( )Tj EMC (2023 \013\013.)Tj 0.083 Tw T* [(\255\205\r\231\234\211\204\217\200\204: )0.6(\f\033\016\b\024\035\037\036\027\016\020\020\032\016 )0.7(\036)]TJ /Span<>> BDC ( )Tj EMC 14.308 0 Td [(\034\025\031\034\033\016 )0.6(\006\016\035\034\b\032 )0.6(\027\016\005\016\020\022\030 )0.6(\024\036\022\235\016\004 )0.6(\f\033\030\006\034\004 )0.5(\021\022\001\021\022 )0.5(\024)]TJ /Span<>> BDC ( )Tj EMC 20.694 0 Td [(\f\033\022\006\016\020\016\020\022\016 )0.5(\025\022\034\f\027\037\024\035\022)]TJ 0 Tw (-)Tj 0.021 Tw -35.002 -1.111 Td (\005\016\024\021\022\002 \006\037\035\016\033\022\037\027\034\036 \020\016\ \034\021\037\031\032\036\037\026\035 \034\035\033\022\007\037\035\016\027\ \003\020\034\013\034 \036\027\022\030\020\022\030 \020\037)Tj /Span<>> BDC ( )Tj EMC (\017\023\020\021\007\022\034\020\037\027\003\020\032\016 \f\034\021\037\031\ \037\035\016\027\022 \006\032\001\007 \031\037\f\022\033\037)Tj 0 Tw (-)Tj 0.103 Tw T* (\035\016\027\003\020\034\013\034 \037\f\f\037\033\037\035\037 \f\033\030\ \006\034\004 \021\022\001\021\022, \034\b\020\037\021\034 \006\020\034\013\ \022\016 \022\031)Tj /Span<>> BDC ( )Tj EMC (\020\022\002 \024\034\f\033\034\036\034\201\b\037\026\035\024\030 \036\032\ \024\034\021\022\006 \f\033\034\007\016\020\035\034\006 \033\037\031\036\ \022\035\022\030 )Tj 0.054 Tw T* (\033\016\007\022\b\022\036\037 \031\037\025\034\027\016\036\037\020\022\030\ . \215\005\022\035\032\036\037\030 \025\016\031\034\f\037\024\020\034\024\ \035\003 \022\024\f\034\027\003\031\034\036\037\020\022\030 \025\022\034\ \006\037\035\016\033\022\037\027\034\036, \020\016\024\006\034\035\033\030\ \020\037)Tj /Span<>> BDC ( )Tj EMC (\036\032\024\034\021\022\004 \033\022\024\021 )Tj 0.171 Tw T* (\033\037\031\036\022\035\022\030 \033\016\007\022\b\022\036\037, \f\033\022\ \006\016\020\016\020\022\016 \022\002 \034\f\033\037\036\b\037\020\034 \036\ )Tj /Span<>> BDC ( )Tj EMC (\021\037\005\016\024\035\036\016 \f\016\033\036\034\004 \027\022\020\022\ \022 \027\016\005\016\020\022\030 \024\036\022\235\016\004 \f\033\030\006\ \034\004 \021\022\001\021\022. )Tj 0.166 Tw 0 -1.111 TD [(\240\b\020\037\021\034 )0.6(\035\033\016\025\023\016\035\024\030 )0.5(\b\037\027\003\020\016\004\001\016\016 )0.6(\022\031\023\005\016\020\022\016 )0.5(\017\037\021\035\034\033\034\036 )0.6(\033\022\024\021\037 )0.5(\033\037\031\036\022\035\022\030 )0.5(\033\016\007\022\b\022\036\034\036 )0.5(\022)]TJ /Span<>> BDC ( )Tj EMC 35.144 0 Td [(\006\034\b\016\033\020\022\031\037\007\022\030 )0.5(\006\016\035\034\b\022\021 )]TJ 0.023 Tw -35.144 -1.111 Td (\024)Tj /Span<>> BDC ( )Tj EMC (\022\002 \023\005\016\035\034\006.)Tj /T1_2 1 Tf 0.01 Tc 0.018 Tw 8 0 0 8 42.5596 355.3795 Tm [(\037\033\016\r\030\025\f\030)5( \026\033\036\025\021:)]TJ /T1_1 1 Tf 0 Tc 0.023 Tw 8.493 0 Td ( \024\036\022\235 \f\033\030\006\034\004 \021\022\001\021\022, \f\033\030\ \006\034\021\022\001\016\005\020\032\004 \024\036\022\235, \021\033\022\f\ \035\034\013\027\037\020\b\023\027\030\033\020\032\004 \024\036\022\235,\ \017\022\025\033\022\020\034\036\032\004 \021\027\016\004, \021\034\027\ \027\037\013\016\020\034\036\032\004 \022\006\f\027\037\020\035)Tj /T1_2 1 Tf 0.01 Tc 0.018 Tw -8.493 -1.909 Td [(\037\036\035\034\033\032\037\031)5( \032\035\031\030\027\030\026\036\025:)]TJ /T1_1 1 Tf 0 Tc 0.023 Tw 10.401 0 Td ( \037\036\035\034\033\032 \031\037\030\036\027\030\026\035 \034\025 \034\ \035\024\023\035\024\035\036\022\022 \021\034\020\017\027\022\021\035\037\ \022\020\035\016\033\016\024\034\036)Tj /T1_2 1 Tf 0.033 Tc 0.051 Tw -10.401 -2.617 Td [(\024\033\023)4.7( \022\032\031\032\027\036\025\021\035\032\023:)]TJ /T1_3 1 Tf 0.023 Tc 0.056 Tw 9.224 0 Td ( \214\026\026\030\036\r)Tj /Span<>> BDC ( )Tj EMC (\025.\202., \200\t\001\036\020\024\030\024\007\006\036\r \212.\200., \207\ \024\020\024\030\n\017\f\021\030\024\r)Tj /Span<>> BDC ( )Tj EMC (\236.\224., \025\024\030\024\035\017\022)Tj /Span<>> BDC ( )Tj EMC (\200.\222. \215\030\017\n\036\027\036\027\017\036 \235\017\002\030\017\027\ \024\r\024\020\024 \022\035\036\016 \017)Tj /Span<>> BDC ( )Tj EMC (\002\017\024)Tj 0 Tc 0 Tw (-)Tj 0.023 Tc 0.083 Tw -9.229 -1.2 Td (\023\035\026\f\021\017\004\036\f\022\017\b \017\n\023\035\026\027\021\024\ \r \r)Tj /Span<>> BDC ( )Tj EMC (\035\036\004\036\027\017\017 \f\r\017\013\036\005 \023\030\016\n\024\005\ \022\017\001\022\017 \(\024\002\024\030 \035\017\021\036\030\026\021\031\ \030\t\). )Tj /T1_1 1 Tf -0.023 Tw (\r\034\027\034\f\033\034\021\035\034\027\034\013\022\030.)Tj /T1_3 1 Tf 0.083 Tw ( 2025; \021.)Tj /Span<>> BDC ( )Tj EMC (24, \223)Tj /Span<>> BDC ( )Tj EMC (4, \f.)Tj /Span<>> BDC ( )Tj EMC [(167\226176.)23( )]TJ -0.023 Tw 0 -1.2 TD (https://doi.org/10.33878/2073-7556-2025-24-4-167-176)Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 0 Tc 0.023 Tw 18 0 0 18 146.6224 267.6331 Tm (Fibrin glue and bioplastic implants )Tj -0.511 -1.167 Td [(in\022)-23.3(tr)31.1(eatment of\022)-23.3(r)31(ectal f)-21(istulas \(r)31(e)11(vie)11(w\))]TJ 0 0 0 1 k /GS1 gs 14 0 0 14 42.5197 222.1292 Tm [(Kirill\022)-23.2(A)-31(.\022)-23.3(La)20(z)15(ar)31(e)11(v)21(, Dmitriy\022)-23.3(V)62(.\022)-23.3(V)30(y)10(sh)11(egor)20.1(odce)11(v)20.9(, Ily)21(a\022)-23.3(S.\022)-23.3(Bogormistr)20.1(ov)21(, )]TJ 0 Tw 0 -1.143 TD [(V)30(y)21(ach)11(eslav\022)-23.2(Y)40(u.\022)-23.3(K)41(or)20(olik)]TJ 0.023 Tw 10 0 0 10 42.5197 188.46 Tm [(R)20(y)21(zhikh National Medical Resear)31(ch Center of\022)-23.3(Colopr)20.1(octology \(Saly)21(ama Adily)21.1(a\022)-23.3(st., 2, Moscow)22(, 1)125(23)58(423, Russia\))]TJ /T1_1 1 Tf 0.037 Tw 9 0 0 9 90.7087 169.956 Tm [(INTR)19(ODUCTION: v)16(ar)-36.9(ious surgical techniq)14(ues are used in rectal f)-43(istula treatment how)12(ev)13(er all of)]TJ /Span<>> BDC ( )Tj EMC [(them can neg)12(ativ)12.9(ely )]TJ 0.074 Tw 0 -1.111 TD [(ef)-40(fect on anal sphincter)51.1(. One of)]TJ /Span<>> BDC ( )Tj EMC [(the most ser)-36.9(ious com)16(plications is the)]TJ /Span<>> BDC ( )Tj EMC [(dev)13(elopment of)]TJ /Span<>> BDC ( )Tj EMC [(postoperativ)13(e insuf)-40(f)-43(iciency )]TJ 0.052 Tw T* (of)Tj /Span<>> BDC ( )Tj EMC [(the anal sphincter)51.1(. The)]TJ /Span<>> BDC ( )Tj EMC (introduction of)Tj /Span<>> BDC ( )Tj EMC [(v)16(ar)-37(ious bioplastic mater)-36.9(ials signif)-42.9(icantly inf)-21.9(luences on the)]TJ /Span<>> BDC ( )Tj EMC [(dev)13(elopment )]TJ 0.023 Tw T* (of)Tj /Span<>> BDC ( )Tj EMC (low-traumatic operations.)Tj T* (AIM: to)Tj /Span<>> BDC ( )Tj EMC [(ev)16(aluate the)]TJ /Span<>> BDC ( )Tj EMC [(ef)-40(fectiv)13(eness of)]TJ /Span<>> BDC ( )Tj EMC [(f)-43(ibr)-37(in g)13(lue and bioplastic im)16.1(plants usag)12(e in treatment of)]TJ /Span<>> BDC ( )Tj EMC [(rectal f)-42.9(istulas.)]TJ 0.047 Tw 0 -1.111 TD [(P)45(A)45(TIENT)-9.9(S A)53.1(ND METHODS: literature back)15(g)14(round w)13(as searched in sev)13(eral d)26(atabases: PubMed, eLibrar)-43(y and K)18(ohrane. )]TJ 0.006 Tw 0 -1.111 TD [(842 ar)-40(ticles on bioplastic im)16(plants and f)-43(ibr)-37(in g)13(lue w)12(ere found. The)]TJ /Span<>> BDC ( )Tj EMC [(ar)-40(ticles w)12(ere selected according to)]TJ /Span<>> BDC ( )Tj EMC (the following )Tj 0.073 Tw T* [(cr)-37(iter)-36.9(ia: the)]TJ /Span<>> BDC ( )Tj EMC 5.051 0 Td [(structure, )0.5(consistency)42.1(, relev)16(ance and )0.5(evidence )0.5(\(the p)46(resence of)]TJ /Span<>> BDC ( )Tj EMC [(suppor)-40(ting link)-23(s to)]TJ /Span<>> BDC ( )Tj EMC [(or)-37(iginal research\) )]TJ 0.013 Tw -5.051 -1.111 Td (of)Tj /Span<>> BDC ( )Tj EMC [(the te)-14.9(xt, infor)-13.9(mation about the)]TJ /Span<>> BDC ( )Tj EMC [(author\237)37(s publications)33.1(\237 subjects, the)]TJ /Span<>> BDC ( )Tj EMC (number of)Tj /Span<>> BDC ( )Tj EMC (citations of)Tj /Span<>> BDC ( )Tj EMC [(the ar)-40(ticles. The)]TJ /Span<>> BDC ( )Tj EMC [(e)-15(xclu)]TJ 0 Tw (-)Tj 0.111 Tw T* [(sion cr)-37(iter)-36.9(ia w)12(ere f)-43(istulas associated with inf)-21.9(lammator)-42.9(y bow)12.1(el diseases, post-traumatic and post-radiation ones. )]TJ ET 1 0.68 0 0.12 k /GS0 gs q 1 0 0 1 42.5197 589.1533 cm 0 0 m 0 0 l 0 -11.339 l 42.52 -11.339 l 42.52 0 l h f Q BT 0 0 0 0 k /T1_2 1 Tf 0 Tw 9 0 0 9 47.6607 580.226 Tm (\027\030\013\016\n\030)Tj ET 1 0.68 0 0.12 k q 1 0 0 1 42.5197 178.4604 cm 0 0 m 0 0 l 0 -11.339 l 42.52 -11.339 l 42.52 0 l h f Q BT 0 0 0 0 k /T1_2 1 Tf 9 0 0 9 45.2263 169.5332 Tm (ABSTRACT)Tj ET q 0 0 566.929 793.701 re W n BT 1 0.68 0 0.12 k /T1_4 1 Tf 0.01 Tc 0.018 Tw 14 0 0 14 42.5895 837.3533 Tm [(\004\210)42(\215\004\n)5( \b\006\r\207\n)43(\037)31(\r)-21(\013\n\233)]TJ /T1_0 1 Tf -0.01 Tw 0 -1.605 TD (REVIEW)Tj ET Q BT 1 0.68 0 0.12 k /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\206)10(\002\036\033 \035\030\032\003\033)30(\n)42(\032)-21(\230\033\241)]TJ 57.136 0 Td (REVIEW)Tj /T1_5 1 Tf 25 0 0 25 505.5644 56.0378 Tm (167)Tj ET q 0 g 0 G 0 j 0 J /Fm1 Do Q 0 0 0 0 k 368.504 725.67 59.155 11.338 re f /PlacedPDF /MC0 BDC q 369.135 736.808 m 368.896 736.808 368.703 736.616 368.703 736.376 c 368.703 736.376 l 368.703 726.285 l 368.703 726.045 368.896 725.853 369.135 725.853 c 369.135 725.853 l 427.035 725.853 l 427.273 725.853 427.469 726.045 427.469 726.285 c 427.469 726.285 l 427.469 736.376 l 427.469 736.616 427.273 736.808 427.035 736.808 c 427.035 736.808 l h W n q 0 g -0.0000005 -10.9560913 -10.9560913 0.0000005 398.0855785 736.8086309 cm BX /Sh0 sh EX Q Q q 368.504 725.67 59.155 11.337 re W n 0 0 0 0.84 k q 1 0 0 1 385.2169 732.4249 cm 0 0 m -0.025 0.1 -0.063 0.196 -0.112 0.287 c -0.157 0.374 -0.218 0.451 -0.292 0.515 c -0.37 0.582 -0.46 0.632 -0.558 0.664 c -0.669 0.701 -0.786 0.719 -0.903 0.717 c -1.076 0.722 -1.247 0.681 -1.4 0.6 c -1.536 0.526 -1.652 0.42 -1.74 0.292 c -1.83 0.158 -1.895 0.008 -1.934 -0.149 c -2.018 -0.48 -2.018 -0.827 -1.934 -1.158 c -1.896 -1.316 -1.83 -1.466 -1.74 -1.602 c -1.653 -1.731 -1.536 -1.837 -1.4 -1.912 c -1.247 -1.993 -1.076 -2.033 -0.903 -2.029 c -0.774 -2.032 -0.647 -2.006 -0.528 -1.955 c -0.427 -1.906 -0.337 -1.837 -0.263 -1.753 c -0.185 -1.665 -0.124 -1.563 -0.082 -1.453 c -0.034 -1.338 0 -1.218 0.019 -1.094 c 0.635 -1.094 l 0.624 -1.297 0.578 -1.497 0.497 -1.684 c 0.421 -1.857 0.312 -2.015 0.175 -2.146 c 0.039 -2.277 -0.123 -2.379 -0.3 -2.446 c -0.492 -2.519 -0.695 -2.555 -0.9 -2.552 c -1.15 -2.557 -1.397 -2.506 -1.625 -2.404 c -1.829 -2.307 -2.01 -2.169 -2.157 -1.997 c -2.308 -1.821 -2.423 -1.617 -2.497 -1.397 c -2.655 -0.924 -2.655 -0.412 -2.497 0.061 c -2.423 0.281 -2.307 0.485 -2.157 0.661 c -2.01 0.833 -1.829 0.973 -1.625 1.07 c -1.398 1.174 -1.15 1.226 -0.9 1.222 c -0.707 1.223 -0.515 1.196 -0.329 1.14 c -0.159 1.088 0.001 1.006 0.144 0.898 c 0.278 0.793 0.39 0.662 0.473 0.513 c 0.562 0.349 0.615 0.167 0.629 -0.019 c 0 -0.019 l 0 0 l f Q q 1 0 0 1 386.3458 733.5723 cm 0 0 m 0.584 0 l 0.584 -1.328 l 0.662 -1.204 0.771 -1.103 0.9 -1.033 c 1.046 -0.951 1.213 -0.91 1.381 -0.914 c 1.627 -0.9 1.869 -0.979 2.058 -1.137 c 2.234 -1.312 2.325 -1.556 2.305 -1.803 c 2.305 -3.596 l 1.716 -3.596 l 1.716 -1.976 l 1.724 -1.817 1.678 -1.66 1.585 -1.53 c 1.486 -1.43 1.347 -1.379 1.206 -1.392 c 1.114 -1.39 1.024 -1.408 0.94 -1.445 c 0.865 -1.479 0.798 -1.529 0.744 -1.591 c 0.687 -1.656 0.645 -1.73 0.616 -1.812 c 0.586 -1.896 0.571 -1.986 0.571 -2.077 c 0.571 -3.615 l 0 -3.615 l 0 0 l f Q q 1 0 0 1 389.692 731.1235 cm 0 0 m 0 -0.099 0.014 -0.198 0.043 -0.292 c 0.069 -0.382 0.112 -0.466 0.17 -0.54 c 0.229 -0.611 0.304 -0.669 0.388 -0.709 c 0.486 -0.754 0.594 -0.776 0.702 -0.773 c 0.845 -0.78 0.987 -0.742 1.108 -0.664 c 1.217 -0.582 1.296 -0.468 1.336 -0.337 c 1.881 -0.337 l 1.827 -0.603 1.675 -0.838 1.456 -0.996 c 1.35 -1.073 1.231 -1.131 1.105 -1.169 c 0.971 -1.208 0.831 -1.229 0.691 -1.227 c 0.509 -1.227 0.328 -1.191 0.16 -1.121 c 0.007 -1.063 -0.13 -0.972 -0.244 -0.855 c -0.356 -0.73 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P)30.1(er)-10(sonal)-31(iza)15(t)-32(ion of)]TJ /Span<>> BDC ( )Tj EMC 9.229 0 Td [(t)-13(he choice )]TJ -0.019 Tw -23.437 -1.25 Td (of)Tj /Span<>> BDC ( )Tj EMC [(p)25(r)-24(event)-32(i)-15.9(ve st)17(oma in l)30(o)-14(w anter)-36.9(ior r)-24(esec)-16(t)-32(ion of)]TJ /Span<>> BDC ( )Tj EMC [(t)-13(he r)-24(ec)-16(tum: A)-14(bstr)-33(a)-17(c)-16(t )]TJ 0.139 Tw T* (of)Tj /Span<>> BDC ( )Tj EMC (a)Tj /Span<>> BDC ( )Tj EMC [(disser)-22(t)15(a)15(t)-32(ion for a)]TJ /Span<>> BDC ( )Tj EMC [(PhD degr)-24(ee \(3.1.9)]TJ /Span<>> BDC ( )Tj EMC [(\227 Sur)-32(ger)-23.9(y \(medical sc)-24(i)]TJ 0 Tw (-)Tj 0.023 Tw T* (ences\). M.: [b. i.], 2024; 25)Tj /Span<>> BDC ( )Tj EMC (p. \(In Russ.\).)Tj 0.012 Tc 0.445 Tw T* (41.)Tj /Span<>> BDC ( )Tj EMC 1.844 0 Td (\221\036\035\t\020\017\027)Tj /Span<>> BDC ( )Tj EMC (\222.\202., \232\036\030\027\t\001\024\r)Tj /Span<>> BDC ( )Tj EMC (\224.\200., \217\t\002\026\022\024\r)Tj /Span<>> BDC ( )Tj EMC [(\213.\206. \224\001\017\r\026\027\017\036)12( )]TJ 0.001 Tc 0.349 Tw -1.844 -1.25 Td (\017\035\036\024\f\021\024\n\t \023\030\017\r\024\007\017\021 \022)Tj /Span<>> BDC ( )Tj EMC (\f\027\017\032\036\027\017\033 \023\024\f\035\036\024\023\036\030\026\006\ \017\024\027\027\024\005 \026\002\024\035\036)Tj 0 Tc 0 Tw (-)Tj 0.009 Tc 0.349 Tw T* [(\r\026\036\n\024\f\021\017. \217\026\027\007\024\n\017\017\030\024\r\026\ \027\027\024\036 \022\024\027\021\030\024\035\017\030\031\036\n\024\036 \ \017\f\f\035\036\007\024\r\026\027\017\036.)9.1( )]TJ /T1_1 1 Tf 0.01 Tc 0.367 Tw T* [(T)54.2(ech Colop)46.2(roctol.)]TJ /T1_0 1 Tf [( 2010 Mar;14\(1\):19\22623. d)-15.9(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs -0.01 Tw (10.1007/s10151-)Tj 0 Tc 0 Tw T* (009-0550-y)Tj 0 0 0 1 k /GS1 gs 0.233 Tw [( Epub 2009 Dec 15. / S)-16(hel)35(ygin)]TJ /Span<>> BDC ( )Tj EMC [(Y.A., Cher)-15(ny)-13(shov)]TJ /Span<>> BDC ( )Tj EMC (S.V., )Tj 0.057 Tw T* [(R)-20(ybakov)]TJ /Span<>> BDC ( )Tj EMC 3.636 0 Td [(E.G. )0.5(S)15(t)15(apled ileost)17.1(omy cl)30(osur)-23.9(e r)-24(esul)56.1(ts in r)-23.9(educ)-16(t)-32(ion of)]TJ /Span<>> BDC ( )Tj EMC 21.907 0 Td (post)Tj 0 Tw (-)Tj 0.108 Tw -25.543 -1.25 Td [(oper)-33(a)15(t)-32(i)-15.9(ve mor)-24(bidi)-24(t)-9.9(y. 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\(\024\016\026)11(\001\001\215\001\t\021\213\022\021\022\b\021\b)-10(\026)11(\016\024\001\026\021\f\016\b\017\021\207 \025\235\213\025\201 \t\021\026\ )11(\016\201\001\026)-20(\200\201\220\))]TJ 41.159 1 Td [(Pr)31(e)11(v)12(entiv)12.1(e intestinal stoma: ileostom)21(y)31(, colostom)21(y)52(. )]TJ -4.661 -1 Td [(W)30(hich\022option\022is\022safer? \(meta-analy)10(sis and s)10(y)10(stematic r)31(e)11(vie)11(w\))]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0.179 Tw 8 0 0 8 42.5197 731.2159 Tm (\235\026\022\021\024\030\024\r, \r\035\017\016\033\013\017\b \027\026)Tj /Span<>> BDC ( )Tj EMC (\027\036\f\024\f\021\024\016\021\036\035\034\027\024\f\021\034 \022\024\035\ \024\030\036\022\021\026\035\034\027\t\b \026\027\026)Tj 0 Tw (-)Tj 0.005 Tw 0 -1.25 TD (\f\021\024\n\024\024\r: \030\036\021\030\024\f\023\036\022\021\017\r\027\ \024\036 \017\f\f\035\036\007\024\r\026\027\017\036. )Tj /T1_2 1 Tf (\r\027\022\020\022\005\016\024\021\037\030 \022)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\f\016\033\022)Tj 0 Tw (-)Tj -0.021 Tw T* [(\006\016\020\035\037\027\003\020\037\030 )0.6(\002\022\033\023\033\013\022\030.)]TJ /T1_1 1 Tf [( )0.5(\240\031\030\027\026\035 )0.5(\017\n\036\027\017 )0.6(\026\022\026\007\036\n\017\022\026 )0.5(\207.\200. )0.5(\215\036\021\030\024\r\f\022\024\020\024. )]TJ 0.245 Tw T* [(2021; 9, \(1\): 37\22644. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.33029/2308-1198-2021-9-1-37-44)Tj 0 0 0 1 k /GS1 gs 0.245 Tw ( / )Tj 0.308 Tw T* [(P)10(ol)-31(ishchuk)]TJ /Span<>> BDC ( )Tj EMC 4.939 0 Td [(L.O., )0.6(V)30(e)-12(tshev)]TJ /Span<>> BDC ( )Tj EMC 5.978 0 Td [(F.P., )0.6(P)30(e)-12(tr)-24(enko)]TJ /Span<>> BDC ( )Tj EMC 6.379 0 Td [(K.N., )0.6(e)-12(t)]TJ /Span<>> BDC ( )Tj EMC 3.796 0 Td [(al. )0.6(R)-24(isk )0.5(f)16(a)-17(c)-16(t)17.1(or)-10(s )]TJ 0.337 Tw -21.092 -1.25 Td [(for )0.5(col)30(or)-24(ec)-16(t)15.1(al anast)17(omo)17.1(t)-32(ic )0.5(leak)-17(a)-17(ge: )0.5(r)-24(e)-12(tr)-32(ospec)-16(t)-31.9(i)-16(ve )0.5(stud)17(y. )]TJ /T1_2 1 Tf 0 Tw 24.801 0 Td (Clinical )Tj 0.166 Tw -24.801 -1.25 Td [(and )0.5(Exper)-37(imental )0.6(Surg)12(er)-43(y.)]TJ /T1_1 1 Tf 0 Tw ( )Tj /T1_2 1 Tf 0.166 Tw 11.07 0 Td [(P)15(etrovsky )0.5(Jour)-13.9(nal.)]TJ /T1_1 1 Tf [( )0.5(2021;9\(1\):37\22644. )0.5(\(in )]TJ 0.023 Tw -11.07 -1.25 Td [(Russ.\). d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.33029/2308-1198-2021-9-1-37-44)Tj 0 0 0 1 k /GS1 gs 0.015 Tc 0.543 Tw T* (6.)Tj /Span<>> BDC ( )Tj EMC 1.341 0 Td (\236\r\026\027\024\r)Tj /Span<>> BDC ( )Tj EMC (\222.\200., \224\n\017\030\027\024\r)Tj /Span<>> BDC ( )Tj EMC (\202.\200., \212\026\r\017\007\024\r\017\004)Tj /Span<>> BDC ( )Tj EMC (\212.\214., \017)Tj /Span<>> BDC ( )Tj EMC [(\f\024\026\r\021.)15( )]TJ 0.014 Tc 0.529 Tw -1.341 -1.25 Td [(\215\030\036\007\017\022\021\024\030\t \027\036\f\024\f\021\024\016\021\036\ \035\034\027\024\f\021\017 \022\024\035\024\030\036\022\021\026\035\034\027\ \024\020\024 \026\027\026\f\021\024\n\024\026)14( )]TJ 0 Tc 0.339 Tw T* (\023\024\f\035\036 \023\036\030\036\007\027\017\b \030\036\036\022\006\017\ \005 \023\030\016\n\024\005 \022\017\001\022\017 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\035\024\022\026\035\017\024\r\026\027\027\t\b )Tj 0.013 Tc 0.484 Tw T* (\035\024\022\026\004\036\f\021\r\036\027\027\t\b \027\024\r\024\024\002\ \030\026\024\r\026\027\017\016\b. )Tj /T1_2 1 Tf (\r\027\022\020\022\005\016\024\021\037\030 \f\033\037\021\035\022\021\037\ .)Tj /T1_1 1 Tf 0 Tc 0 Tw 27.638 0 Td ( )Tj 0.275 Tw -27.638 -1.25 Td [(2024;15\(1\):7\22616. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw [(10.17816/cl)-31(in)11(p)25(r)-33(a)-17(c)-16(t623690)]TJ 0 0 0 1 k /GS1 gs 0.275 Tw [( / Iv)-15(anov Y)35(u.V., )]TJ 0.343 Tw T* [(Smir)-15(nov)]TJ /Span<>> BDC ( )Tj EMC [(A.V., Dav)-16(id)-16(ov)-15.9(ich)]TJ /Span<>> BDC ( )Tj EMC [(D.L., e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. P)35(r)-24(edic)-16(t)17(or)-10(s of)]TJ /Span<>> BDC ( )Tj EMC [(anast)17(omo)17(t)-32(ic )]TJ 0.222 Tw T* [(leak af)-28(ter anter)-37(ior r)-24(ec)-16(t)15(al r)-24(esec)-16(t)-32(ions for l)30(o)-16(cal)-31(ized mal)-31(ignant neo)]TJ 0 Tw (-)Tj T* [(pl)-16(as)26(ms. )]TJ /T1_2 1 Tf 0.245 Tw 3.486 0 Td [(Jour)-13.9(nal )0.5(of)]TJ /Span<>> BDC ( )Tj EMC 4.73 0 Td [(Clinical )0.6(Practice. )]TJ /T1_1 1 Tf 7.22 0 Td [(2024;15\(1\):7\22616. )0.6(\(In )0.5(Russ.\). )]TJ 0 Tw -15.436 -1.25 Td [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td [(10.17816/cl)-31(in)11(p)25(r)-32.9(a)-17(c)-16(t623690)]TJ 0 0 0 1 k /GS1 gs 0.018 Tw -1.847 -1.25 Td (7.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Dekk)10(er JW)-16(i)-15(T, L)-32(iefer)-9.9(s)]TJ /Span<>> BDC ( )Tj EMC [(GJ, de M)-23.9(ol v)-15(an Ot)-30(ter)-29.9(l)30(o)-16(o)]TJ /Span<>> BDC ( )Tj EMC [(JC)20(A, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. P)35(r)-24(edic)-16(t)-32(ing )]TJ 0.297 Tw -1.296 -1.25 Td [(t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(r)-37(isk of)]TJ /Span<>> BDC ( )Tj EMC [(anast)17.1(omo)17(t)-32(ic leak)-16.9(a)-17(ge in lef)-28(t-sided col)30(or)-24(ec)-16(t)15.1(al sur)-31.9(ger)-24(y )]TJ 0.14 Tw T* [(using )0.5(a)]TJ /Span<>> BDC ( )Tj EMC [(col)30(on )0.5(leak)-17(a)-17(ge scor)-23.9(e. )]TJ /T1_2 1 Tf [(J )0.5(Surg R)21(es.)]TJ /T1_1 1 Tf ( 2011 Mar;166\(1\):e27\22634. )Tj 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1016/j.jss.2010.11.004)Tj 0 0 0 1 k /GS1 gs 0.216 Tw -1.847 -1.25 Td (8.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (H\374ser)Tj /Span<>> BDC ( )Tj EMC [(N, Michalsk)-15.9(i)]TJ /Span<>> BDC ( )Tj EMC [(CW, Er)-24(k)-17(an)]TJ /Span<>> BDC ( )Tj EMC [(M, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Sy)-12.9(stema)15(t)-32(ic R)13(ev)-16(iew and )]TJ 0.236 Tw -1.296 -1.25 Td [(Me)-12(t)15(a-Anal)35.1(y)-13(sis of)]TJ /Span<>> BDC ( )Tj EMC [(t)-13(he R)11(ole of)]TJ /Span<>> BDC ( )Tj EMC [(Defunc)-15.9(t)-32(ioning S)15(t)17(oma in L)35(o)-14(w R)13(ec)-16(t)15(al )]TJ 0.232 Tw T* [(Cancer Sur)-32(ger)-23.9(y. )]TJ /T1_2 1 Tf (Ann Surg. )Tj /T1_1 1 Tf [(2008 Jul;248\(1\):52\22660. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1097/)Tj T* [(SL)-35(A.0b013e318176bf65)]TJ 0 0 0 1 k /GS1 gs 0.01 Tc 0.381 Tw T* (9.)Tj /Span<>> BDC ( )Tj EMC 1.327 0 Td [(M)-24.2(oher)]TJ /Span<>> BDC ( )Tj EMC [(D, L)-32.2(iber)-33.2(a)14.8(t)-32.2(i)]TJ /Span<>> BDC ( )Tj EMC [(A, T)39.8(e)-12.2(tzl)-16.2(af)-56.2(f)]TJ /Span<>> BDC ( )Tj EMC [(J, e)-12.2(t)]TJ /Span<>> BDC ( )Tj EMC [(al. T)46.8(he)]TJ /Span<>> BDC ( )Tj EMC [(PRISMA G)19.8(r)-32.2(oup)10( )]TJ 0.012 Tc 0.45 Tw -1.327 -1.25 Td [(P)34.8(r)-24.2(efer)-24.2(r)-24.1(ed R)12.8(epor)-22.2(t)-32.2(ing Items for Sy)-13.1(stema)14.8(t)-32.1(ic R)12.8(ev)-16.2(iews and Me)-12.2(t)14.8(a)12( )]TJ 0 Tc 0.201 Tw T* [(Anal)35(y)-13(ses: T)47(he)]TJ /Span<>> BDC ( )Tj EMC [(PRISMA S)15(t)15(a)15(tement. )]TJ /T1_2 1 Tf (PLoS Med.)Tj /T1_1 1 Tf ( 2009;6\(7\):e1000097. )Tj 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td [(10.1371/jour)-14.9(nal.pmed.1000097)]TJ 0 0 0 1 k /GS1 gs 0.138 Tw -1.847 -1.25 Td (10.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(S)15(t)15(ang)]TJ /Span<>> BDC ( )Tj EMC [(A. Cr)-36.9(i)-24(t)-32(ical ev)-15(al)35.1(ua)15(t)-32(ion of)]TJ /Span<>> BDC ( )Tj EMC [(t)-13(he Newcastle-Ot)-29.9(t)15(a)10(w)-12(a scale for )]TJ 0.168 Tw -1.796 -1.25 Td [(t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(assess)26(ment of)]TJ /Span<>> BDC ( )Tj EMC [(t)-13(he qual)-30.9(i)-24(t)-10(y of)]TJ /Span<>> BDC ( )Tj EMC [(nonr)-33(and)-16(omized studies in me)-12(t)15(a-)]TJ 0 Tw T* [(anal)35(y)-13(ses. )]TJ /T1_2 1 Tf 0.285 Tw 4.186 0 Td (Eur J Epidemiol.)Tj /T1_1 1 Tf [( 2010 Sep;25\(9\):603\2265. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1007/)Tj -4.186 -1.25 Td (s10654-010-9491-z)Tj 0 0 0 1 k /GS1 gs 0.023 Tw ( Epub 2010 Jul 22.)Tj 0.108 Tw T* (11.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(\307ap)32(ar)-30(l)-16(ar)]TJ /Span<>> BDC ( )Tj EMC (MA, Dok\347u)Tj /Span<>> BDC ( )Tj EMC [(\277, Demir)-32(c)-24(i)]TJ /Span<>> BDC ( )Tj EMC [(S. L)35(o)-16(op ileost)17.1(omy or l)30(o)-16(op col)30(os)]TJ 0 Tw (-)Tj 0.08 Tw -1.796 -1.25 Td [(t)17(omy for r)-24(esec)-15.9(t)15(able r)-24(ec)-16(t)15(al cancer)-10(s? )]TJ /T1_2 1 Tf [(Eur R)21(es)]TJ /Span<>> BDC ( )Tj EMC (J)Tj /T1_1 1 Tf [(. 2022. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.18621/)Tj T* [(eur)-46(j.914951)]TJ 0 0 0 1 k /GS1 gs 0.184 Tw T* (12.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Car)-37(ica)15.1(t)17(o)]TJ /Span<>> BDC ( )Tj EMC [(M, A)10(usania)]TJ /Span<>> BDC ( )Tj EMC [(F, R)-24(ipe)-11.9(t)-30(t)-32(i)]TJ /Span<>> BDC ( )Tj EMC [(V, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. R)13(e)-11.9(tr)-32(ospec)-16(t)-32(i)-16(ve anal)35(y)-13(sis )]TJ 0.283 Tw -1.796 -1.25 Td (of)Tj /Span<>> BDC ( )Tj EMC 1.331 0 Td [(l)30(ong-ter)-15.9(m defunc)-16(t)-32(ioning )0.5(st)17(oma )0.5(com)10(pl)-31(ica)15(t)-32(ions )0.5(af)-27.9(ter )0.5(col)30(or)-24(ec)-16(t)15(al )]TJ 0 Tw -1.331 -1.25 Td [(sur)-32(ger)-23.9(y. )]TJ /T1_2 1 Tf 0.07 Tw 3.604 0 Td (Colorectal Dis.)Tj /T1_1 1 Tf [( 2007 Jul;9\(6\):559\22661. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1111/j.1463-)Tj -3.604 -1.25 Td (1318.2006.01187.x)Tj 0 0 0 1 k /GS1 gs 0.046 Tw T* (13.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Ed)-17(w)-12(ar)-23.9(ds)]TJ /Span<>> BDC ( )Tj EMC [(DP, L)35(epping)17(t)17(on-Cl)-15.9(ar)-24(k)10(e)]TJ /Span<>> BDC ( )Tj EMC [(A, Se)-18(xt)17.1(on)]TJ /Span<>> BDC ( )Tj EMC [(R, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. S)15(t)17.1(oma-r)-24(el)-16(a)15(ted )]TJ 0.278 Tw -1.796 -1.25 Td [(com)10(pl)-31(ica)15(t)-31.9(ion )0.5(ar)-24(e )0.6(mor)-24(e )0.5(fr)-23.9(equent )0.6(af)-28(ter )0.5(tr)-32.9(ansver)-10(se )0.6(col)30(ost)17(omy )0.6(t)-13(han )]TJ 0.154 Tw T* [(l)30(o)-16(op ileost)17.1(omy: a)]TJ /Span<>> BDC ( )Tj EMC [(p)25(r)-32(ospec)-16(t)-32(i)-16(ve r)-32.9(and)-16(omized cl)-31(inical tr)-37(ial. )]TJ /T1_2 1 Tf (Br J Surg.)Tj /T1_1 1 Tf 0 Tw ( )Tj 0.023 Tw T* [(2001;88:360\22663. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1046/j.1365-2168.2001.01727.x)Tj 0 0 0 1 k /GS1 gs 0.009 Tc 0.35 Tw T* (14.)Tj /Span<>> BDC ( )Tj EMC 1.832 0 Td [(Go)-16.1(oszen)]TJ /Span<>> BDC ( )Tj EMC [(A)27(W, Geelk)9.9(er)-24(k)9.9(en)]TJ /Span<>> BDC ( )Tj EMC [(RH, Her)-16.1(mans)]TJ /Span<>> BDC ( )Tj EMC 17.213 0 Td [(J, )0.5(e)-12.1(t)]TJ /Span<>> BDC ( )Tj EMC 2.686 0 Td [(al. T)39.9(em)9.9(por)-33(ar)-24.1(y)9( )]TJ 0 Tc 0.284 Tw -21.732 -1.25 Td [(decom)10(p)25(r)-24(ession af)-28(ter col)30(or)-23.9(ec)-16(t)15(al sur)-32(ger)-23.9(y: r)-33(and omized com)10(p)32(ar)-36.9(ison )]TJ 0.246 Tw T* (of)Tj /Span<>> BDC ( )Tj EMC 1.294 0 Td [(l)30(o)-16(op )0.5(ileost)17(omy )0.5(and l)30(o)-16(op )0.5(col)30(ost)17(omy. )]TJ /T1_2 1 Tf 15.616 0 Td [(Br )0.5(J Surg.)]TJ /T1_1 1 Tf [( )0.5(1998;85:76\2269. )]TJ 0 Tw -16.909 -1.25 Td [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1046/j.1365-2168.1998.00526.x)Tj 0 0 0 1 k /GS1 gs 0.119 Tw -1.847 -1.25 Td (15.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Gast)-32(inger)]TJ /Span<>> BDC ( )Tj EMC [(I, Mar)-22(ush)]TJ /Span<>> BDC ( )Tj EMC [(F, S)15(teiner)-22(t)]TJ /Span<>> BDC ( )Tj EMC [(R, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. P)35(r)-32(o)17(tec)-16(t)-31.9(i)-16(ve defunc)-16(t)-32(ion)]TJ 0 Tw (-)Tj 0.081 Tw -1.796 -1.25 Td [(ing st)17.1(oma in l)30(o)-14(w )0.5(anter)-37(ior )0.5(r)-24(esec)-16(t)-31.9(ion for r)-23.9(ec)-16(t)15(al car)-31.9(c)-24(inoma. )]TJ /T1_2 1 Tf [(Br )0.5(J Surg.)]TJ /T1_1 1 Tf 0 Tw ( )Tj 0.023 Tw T* [(2005;92:1137\22642. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1002/bjs.5045)Tj 0 0 0 1 k /GS1 gs 0.055 Tw T* (16.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Khour)-23.9(y)]TJ /Span<>> BDC ( )Tj EMC [(GA, L)35.1(ewis)]TJ /Span<>> BDC ( )Tj EMC [(MC, Melea)-16.9(gr)-32(os)]TJ /Span<>> BDC ( )Tj EMC [(L, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Col)30.1(ost)17(omy or ileost)17(omy )]TJ 0.192 Tw -1.796 -1.25 Td [(af)-28(ter col)30(or)-23.9(ec)-16(t)15(al anast)17(omosis? A)]TJ /Span<>> BDC ( )Tj EMC [(r)-33(and)-15.9(omized tr)-37(ial. )]TJ /T1_2 1 Tf (Ann R Coll Surg )Tj 0 Tw T* [(Eng)13(l.)]TJ /T1_1 1 Tf 0.023 Tw ( 1987;69:57. PMID: 3566123. PMCID: PMC2498441)Tj 0.134 Tw T* (17.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Kl)-31(ink)]TJ /Span<>> BDC ( )Tj EMC [(CD, L)-32(ioupis)]TJ /Span<>> BDC ( )Tj EMC (K, Binneb\366sel)Tj /Span<>> BDC ( )Tj EMC [(M, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Di)-16(ver)-9.9(sion st)17(oma af)-28(ter )]TJ 0.056 Tw -1.796 -1.25 Td [(col)30(or)-24(ec)-15.9(t)15(al sur)-32(ger)-24(y: l)30(o)-16(op col)30(ost)17(omy or ileost)17.1(omy. )]TJ /T1_2 1 Tf (Int J Colorectal Dis.)Tj /T1_1 1 Tf 0 Tw ( )Tj 0.023 Tw T* [(2011;26:431\22636. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1007/s00384-010-1123-2)Tj 0 0 0 1 k /GS1 gs 0.069 Tw T* (18.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(L)-32(a)10(w)]TJ /Span<>> BDC ( )Tj EMC (WL, Chu)Tj /Span<>> BDC ( )Tj EMC (KW, Choi)Tj /Span<>> BDC ( )Tj EMC [(HK. R)-9.9(and)-16(omized cl)-31(inical tr)-37(ial com p)32(ar)-37(ing )]TJ 0.135 Tw -1.796 -1.25 Td [(l)30(o)-16(op ileost)17(omy and l)30(o)-16(op tr)-33(ansver)-9.9(se col)30(ost)17(omy for f)16(ae cal di)-16(ver)-10(sion )]TJ 0.001 Tc 0.35 Tw T* [(foll)29.6(o)-14.4(wing t)16.6(o)16.6(t)14.6(al mesor)-24.4(ec)-16.4(t)14.6(al e)-18.4(x)-13.4(c)-24.4(ision)]TJ /T1_2 1 Tf (. Br J Surg.)Tj /T1_1 1 Tf [( 2002;89:704\2268.)1( )]TJ 0 Tc 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1046/j.1365-2168.2002.02082.x)Tj 0 0 0 1 k /GS1 gs -0.012 Tw -1.847 -1.25 Td (19.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Mal)-16(a)]TJ /Span<>> BDC ( )Tj EMC 2.089 0 Td [(T, Nesbakk)10.1(en)]TJ /Span<>> BDC ( )Tj EMC [(A. )0.5(M)-24(or)-24(bidi)-23.9(t)-10(y r)-23.9(el)-16(a)15(ted t)17(o)]TJ /Span<>> BDC ( )Tj EMC 14.699 0 Td [(t)-13(he )0.5(use of)]TJ /Span<>> BDC ( )Tj EMC 4.202 0 Td (a)Tj /Span<>> BDC ( )Tj EMC [(p)25(r)-31.9(o)16.9(tec)-15.9(t)-32(i)-16(ve )]TJ 0.175 Tw -22.785 -1.25 Td [(st)17(oma in anter)-37(ior r)-23.9(esec)-16(t)-32(ion for r)-24(ec)-16(t)15(al cancer. )]TJ /T1_2 1 Tf (Colorectal Dis.)Tj /T1_1 1 Tf ( 2008 )Tj 0.01 Tc 0.389 Tw T* [(O)-16.4(c)-16.5(t;10\(8\):785\2268. d)-16.4(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs -0.01 Tw (10.1111/j.1463-1318.2007.01456.x)Tj 0 0 0 1 k /GS1 gs 0.389 Tw [( Epub)10( )]TJ 0 Tc 0.023 Tw T* (2008 Jan 10.)Tj 0.241 Tw T* (20.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(P)35(r)-33(assas)]TJ /Span<>> BDC ( )Tj EMC [(D, V)29(ossos)]TJ /Span<>> BDC ( )Tj EMC [(V, R)13(ehder)-9.9(s)]TJ /Span<>> BDC ( )Tj EMC [(A, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. L)35(o)-16(op ileost)17(omy ver)-10(sus )]TJ 0.13 Tw 27.259 81.25 Td [(l)30(o)-16(op col)30.1(ost)17(omy as tem)10.1(por)-33(ar)-24(y dev)-16(ia)15(t)-32(ion af)-28(ter anter)-36.9(ior r)-24(esec)-15.9(t)-32(ion for )]TJ 0.093 Tw T* [(r)-24(ec)-15.9(t)15(al cancer. )]TJ /T1_2 1 Tf [(Lang)12(enbeck)-22.9(s Arch Surg)]TJ /T1_1 1 Tf (. 2020 Dec;405\(8\):1147\2261153. )Tj 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1007/s00423-020-01940-w)Tj 0 0 0 1 k /GS1 gs 0.023 Tw ( Epub 2020 Jul 23.)Tj 0.038 Tw -1.847 -1.25 Td (21.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Rull)-31(ier)]TJ /Span<>> BDC ( )Tj EMC [(E, L)34.9(e T)45(oux)]TJ /Span<>> BDC ( )Tj EMC [(N, L)-32(aur)-24(ent)]TJ /Span<>> BDC ( )Tj EMC [(C, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. L)35(o)-16(op ileost)17.1(omy ver)-9.9(sus l)30(o)-16(op )]TJ 0.134 Tw -1.796 -1.25 Td [(col)30(ost)17(omy for defunc)-15.9(t)-32(ioning l)30(o)-14(w anast)17(omoses dur)-36.9(ing r)-24(ec)-15.9(t)15(al cancer )]TJ 0 Tw T* [(sur)-32(ger)-23.9(y. )]TJ /T1_2 1 Tf 0.016 Tw 3.55 0 Td [(W)29(orld J Surg)]TJ /T1_1 1 Tf [(. 2001;25:274\2267. d)-15.9(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1007/s002680020091)Tj 0 0 0 1 k /GS1 gs 0.117 Tw -3.55 -1.25 Td (22.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Sak)-17(ai)]TJ /Span<>> BDC ( )Tj EMC (Y, Nelson)Tj /Span<>> BDC ( )Tj EMC [(H, L)-32(ar)-9.9(son)]TJ /Span<>> BDC ( )Tj EMC [(D, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. T)40(em)10(por)-33(ar)-24(y tr)-32.9(ansver)-10(se col)30(os)]TJ 0 Tw (-)Tj 0.004 Tc 0.35 Tw -1.796 -1.25 Td [(t)16.8(omy vs l)29.8(o)-16.2(op ileost)16.8(omy in di)-16.2(ver)-10.1(sion; a)]TJ /Span<>> BDC ( )Tj EMC [(case-stud)16.8(y. )]TJ /T1_2 1 Tf (Arch Surg.)Tj /T1_1 1 Tf 0 Tc 0 Tw 27.638 0 Td ( )Tj 0.023 Tw -27.638 -1.25 Td [(2001;136:338\22642. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw [(10.1001/ar)-32(chsur)-31.9(g.136.3.338)]TJ 0 0 0 1 k /GS1 gs 0.003 Tw T* (23.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Xiyu )0.5(Sun, )0.5(Huiqiao )0.5(Han, )0.5(Huizhong )0.5(Qiu, )0.5(e)-12(t)]TJ /Span<>> BDC ( )Tj EMC 16.199 0 Td [(al. )0.5(Com)10(p)32(ar)-36.9(ison )0.5(of)]TJ /Span<>> BDC ( )Tj EMC 7.189 0 Td [(safe)-12(t)-10(y )]TJ 0.055 Tw -25.185 -1.25 Td (of)Tj /Span<>> BDC ( )Tj EMC [(l)30(o)-16(op ileost)17(omy and l)30(o)-16(op tr)-33(ansver)-9.9(se col)30(ost)17(omy for l)30.1(o)-14(w-l)35(ying r)-24(ec)-16(t)15(al )]TJ 0.001 Tc 0.349 Tw T* [(cancer p)32.2(a)15.2(t)-31.8(ients under)-31.8(going anter)-36.7(ior r)-23.8(esec)-15.8(t)-31.8(ion: A)]TJ /Span<>> BDC ( )Tj EMC [(r)-23.8(e)-11.8(tr)-31.8(ospec)-15.8(t)-31.8(i)-15.8(ve,)1( )]TJ 0 Tc 0.016 Tw T* [(single inst)-32(i)-24(tute, p)25(r)-32(opensi)-23.9(t)-10(y scor)-24(e-ma)15(tched stud)17(y. )]TJ /T1_2 1 Tf (J BUON.)Tj /T1_1 1 Tf ( 2019 Jan-)Tj 0.023 Tw T* [(F)10(eb;24\(1\):123\226129.PMID: 30941960.)]TJ 0.02 Tw T* (24.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(W)-16(ill)-30.9(iams)]TJ /Span<>> BDC ( )Tj EMC [(NS, Nas)26(my)-16(t)-13(h)]TJ /Span<>> BDC ( )Tj EMC (DG, Jones)Tj /Span<>> BDC ( )Tj EMC [(D, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. De-func)-15.9(t)-32(ioning st)17(omas: )]TJ 0.163 Tw -1.796 -1.25 Td (a)Tj /Span<>> BDC ( )Tj EMC [(p)25(r)-32(ospec)-16(t)-32(i)-16(ve contr)-31.9(olled tr)-37(ial com)10(p)32(ar)-37(ing l)30(o)-16(op ileost)17(omy wi)-23.9(t)-13(h l)30(o)-16(op )]TJ 0.267 Tw T* [(tr)-33(ansver)-9.9(se col)30(ost)17(omy. )]TJ /T1_2 1 Tf (Br J Surg.)Tj /T1_1 1 Tf [( 1986;73:566\22670. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1002/)Tj T* (bjs.1800730717)Tj 0 0 0 1 k /GS1 gs 0.129 Tw T* (25.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Xin W)16(u, Guole L)-32(in, Huizhong Qiu, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. L)35(o)-16(op ost)17(omy foll)30(o)-13.9(wing )]TJ 0.184 Tw -1.796 -1.25 Td [(l)-16(ap)32(ar)-32(oscopic )0.5(l)30.1(o)-14(w anter)-36.9(ior )0.5(r)-24(esec)-15.9(t)-32(ion )0.5(for )0.5(r)-24(ec)-16(t)15(al )0.5(cancer )0.5(af)-28(ter )0.5(neoad)]TJ 0 Tw (-)Tj 0.181 Tw T* [(juv)-15(ant chemor)-33(adio)17(t)-13(her)-32.9(apy. )]TJ /T1_2 1 Tf [(Eur J Med R)21(es.)]TJ /T1_1 1 Tf [( 2018 Ma)15.1(y 22;23\(1\):24. )]TJ 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1186/s40001-018-0325-x)Tj 0 0 0 1 k /GS1 gs 0.348 Tw -1.847 -1.25 Td (26.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Y)-29(i-W)22(en Y)50(ang, S)-16(heng-Chieh Huang, Hou-Hsuan Cheng, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC (al. )Tj 0.02 Tw -1.796 -1.25 Td [(P)35(r)-32(o)17(tec)-16(t)-31.9(i)-16(ve l)30(o)-16(op ileost)17(omy or col)30(ost)17(omy? a)]TJ /Span<>> BDC ( )Tj EMC [(r)-36.9(isk ev)-15(al)35(ua)15(t)-32(ion of)]TJ /Span<>> BDC ( )Tj EMC (all com)Tj 0 Tw (-)Tj 0.229 Tw T* [(mon com)10(pl)-31(ica)15(t)-31.9(ions. )]TJ /T1_2 1 Tf [(Ann Colop)46(roctol.)]TJ /T1_1 1 Tf [( 2023 Jan 27. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.3393/)Tj T* [(a)-17(c.2022.00710.0101)]TJ 0 0 0 1 k /GS1 gs 0.107 Tw T* (27.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (\202\035\017\036\r)Tj /Span<>> BDC ( )Tj EMC (\236.\236., \224\n\017\030\027\024\r)Tj /Span<>> BDC ( )Tj EMC (\202.\202., \215\026\r\035\024\r)Tj /Span<>> BDC ( )Tj EMC (\217.\200., \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021.)Tj /T1_2 1 Tf 0 Tw ( )Tj /T1_1 1 Tf 20.552 0 Td (\210\f\035\024\032\027\036\027\017\016, )Tj 0.118 Tw -22.348 -1.25 Td (\f\r\016\026\027\027\t\036 \f)Tj /Span<>> BDC ( )Tj EMC (\235\024\030\n\017\030\024\r\026\027\017\036\n \023\030\024\235\017\035\026\ \022\021\017\004\036\f\022\017\b \f\021\024\n \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\b\017\030\031\030)Tj 0 Tw (-)Tj 0.077 Tw T* (\020\017\004\036\f\022\024\n \035\036\004\036\027\017\017 \030\026\022\026\ \023\030\016\n\024\005 \022\017\001\022\017. )Tj /T1_2 1 Tf (\207\022\025\022\033\024\021\022\004 \034\020\021\034\027\034\013\022\005\ \016\024\021\022\002 )Tj 0 Tw T* (\201\023\033\020\037\027.)Tj /T1_1 1 Tf 0.07 Tw [( 2023;22\(2\):112\226119. /Al)-30.9(iev)]TJ /Span<>> BDC ( )Tj EMC [(I.I., Smir)-15(nov)]TJ /Span<>> BDC ( )Tj EMC [(A.A., P)40.1(avl)30(ov)]TJ /Span<>> BDC ( )Tj EMC (R.V., )Tj 0.227 Tw T* [(e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Com)10(pl)-30.9(ica)15(t)-32(ions fr)-32(om t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(for)-16(ma)15.1(t)-32(ion of)]TJ /Span<>> BDC ( )Tj EMC [(p)25.1(r)-24(event)-32(i)-16(ve st)17(omas in )]TJ 0.006 Tw T* [(t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(sur)-32(gical tr)-24(ea)15(tment of)]TJ /Span<>> BDC ( )Tj EMC [(r)-23.9(ec)-16(t)15(al cancer. )]TJ /T1_2 1 Tf [(Siber)-36.9(ian Jour)-13.9(nal of)]TJ /Span<>> BDC ( )Tj EMC (Oncology.)Tj /T1_1 1 Tf 0 Tw ( )Tj 0.268 Tw T* [(2023;22\(2\):112\226119. \(In Russ.\). d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.21294/1814-4861-2023-)Tj T* (22-2-112-119)Tj 0 0 0 1 k /GS1 gs 0.173 Tw T* (28.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (\200\024\030\024\002\034\036\r)Tj /Span<>> BDC ( )Tj EMC (\206.\236., \213\030\024\023\022\017\027)Tj /Span<>> BDC ( )Tj EMC (\215.\200., \217\t\002\026\022\024\r)Tj /Span<>> BDC ( )Tj EMC (\213.\206., \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. \204\036\021\024\007\t )Tj 0.059 Tw -1.796 -1.25 Td (\017)Tj /Span<>> BDC ( )Tj EMC (\030\036\031\035\034\021\026\021\t \r\024\f\f\021\026\027\024\r\017\021\ \036\035\034\027\t\b \024\023\036\030\026\006\017\005 \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\023\030\036\r\036\027)Tj 0 Tw (-)Tj 0.109 Tw T* (\021\017\r\027\t\n\017 \022\017\001\036\004\027\t\n\017 \f\021\024\n\026\ \n\017. )Tj /T1_2 1 Tf 0 Tw (\r\034\027\034\f\033\034\021\035\034\027\034\013\022\030)Tj /T1_1 1 Tf 0.109 Tw (. 2007;3\(21\):22\226)Tj 0.107 Tw T* [(27. / V)29(or)-32(ob)12(yov)]TJ /Span<>> BDC ( )Tj EMC [(G.I., Er)-32(opk)-16(in)]TJ /Span<>> BDC ( )Tj EMC [(P.V., R)-20(ybakov)]TJ /Span<>> BDC ( )Tj EMC [(\213.G., e)-11.9(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Me)-12(t)-13(hods and )]TJ 0.014 Tw T* [(r)-24(esul)56.1(ts of)]TJ /Span<>> BDC ( )Tj EMC [(r)-24(econstr)-22(uc)-15.9(t)-32(i)-16(ve sur)-32(ger)-37(ies in p)32(a)15(t)-32(ients wi)-24(t)-12.9(h p)25(r)-24(event)-32(i)-15.9(ve intes)]TJ 0 Tw (-)Tj 0.023 Tw T* [(t)-32(inal st)17(omas. )]TJ /T1_2 1 Tf 0 Tw [(K)18(olop)46(roktologia)]TJ /T1_1 1 Tf 0.023 Tw (. 2007;3\(21\):22\22627. \(In Russ.\).)Tj 0.004 Tc 0.349 Tw T* (29.)Tj /Span<>> BDC ( )Tj EMC 1.812 0 Td (\212\026\030\002\017\001\020\026\007\032\017\036\r)Tj /Span<>> BDC ( )Tj EMC (\221.\210., \207\026\031\035\017\027)Tj /Span<>> BDC ( )Tj EMC (\202.\202., \003\017\n\017\027)Tj /Span<>> BDC ( )Tj EMC (\222.\236., \017)Tj /Span<>> BDC ( )Tj EMC [(\f\024\026\r\021.)4( )]TJ 0.011 Tc 0.421 Tw -1.812 -1.25 Td [(\224\021\030\031\022\021\031\030\026 \024\f\035\024\032\027\036\027\017\005\ )0.5(\023\030\017)]TJ /Span<>> BDC ( )Tj EMC (\235\024\030\n\017\030\024\r\026\027\017\017 \017)Tj /Span<>> BDC ( )Tj EMC (\026\022\030\t\021\017\017 \023\030\036)Tj 0 Tc 0 Tw (-)Tj 0.013 Tc 0.468 Tw T* (\r\036\027\021\017\r\027\t\b \017\035\036\024- \017)Tj /Span<>> BDC ( )Tj EMC (\022\024\035\024\f\021\024\n. )Tj /T1_2 1 Tf (\215\033\037\027\003\024\021\022\004 \006\016\b\022\007\022\020\024\021\022\ \004 \201\023\033)Tj 0 Tc 0 Tw (-)Tj 0.017 Tc -0.017 Tw T* (\020\037\027)Tj /T1_1 1 Tf 0.61 Tw [(. 2020;5\(188\):81\22685. d)-15.8(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs -0.017 Tw (10.25694/URMJ.2020.05.19)Tj 0 0 0 1 k /GS1 gs 0 Tc 0.627 Tw ( / )Tj 0.083 Tw T* [(Dar)-24(bishgad)17.1(zhiev S)-16(h.O., Baul)-30.9(in)]TJ /Span<>> BDC ( )Tj EMC [(A.A., Z)-16(imin Y)35(u.I., e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. T)47(he)]TJ /Span<>> BDC ( )Tj EMC [(str)-21.9(uc)-16(tur)-24(e )]TJ 0.224 Tw T* (of)Tj /Span<>> BDC ( )Tj EMC [(com)10(pl)-31(ica)15(t)-32(ions dur)-37(ing t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(for)-16(ma)15(t)-32(ion and cl)30(osur)-23.9(e of)]TJ /Span<>> BDC ( )Tj EMC [(p)25(r)-24(event)-31.9(i)-16(ve )]TJ 0.075 Tw T* [(ileost)17(omy and col)30(ost)17(omy. )]TJ /T1_2 1 Tf [(U)22(ral Medical Jour)-14(nal.)]TJ /T1_1 1 Tf ( 2020;5\(188\):81\22685. )Tj 0.023 Tw T* [(\(In Russ.\). d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.25694/URMJ.2020.05.19)Tj 0 0 0 1 k /GS1 gs 0.015 Tw T* (30.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (\224\036\r\024\f\021\034\016\027\024\r)Tj /Span<>> BDC ( )Tj EMC (\224.\236., \025\026\035\026\001\027\017\022\024\r)Tj /Span<>> BDC ( )Tj EMC (\200.\203., \232\036\030\027\t\001\024\r)Tj /Span<>> BDC ( )Tj EMC (\224.\200. \215\024\022\026\026\027\017\016 )Tj 0.145 Tw -1.796 -1.25 Td (\017)Tj /Span<>> BDC ( )Tj EMC (\r\t\002\024\030 \r\017\007\026 \023\030\036\r\036\027\021\017\r\027\024\ \005 \f\021\024\n\t \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\023\035\026\027\024\r\t\b \b\017\030\031\030\020\017\004\036\f\022\017\b\ )Tj 0.017 Tw T* (\r\n\036\001\026\021\036\035\034\f\021\r\026\b \023\024)Tj /Span<>> BDC ( )Tj EMC (\023\024\r\024\007\031 \030\026\022\026 \023\030\016\n\024\005 \022\017\001\ \022\017. )Tj /T1_2 1 Tf 0 Tw (\r\034\027\034\f\033\034\021\035\034\027\034\013\022\030)Tj /T1_1 1 Tf (. )Tj 0.022 Tw T* [(2005;3:33\22638. / Sevost)-10(y)22(anov)]TJ /Span<>> BDC ( )Tj EMC [(S.I., K)-16(al)-16(ashnikov)]TJ /Span<>> BDC ( )Tj EMC [(V.N., Cher)-15(ny)-13(shov)]TJ /Span<>> BDC ( )Tj EMC (S.V. )Tj 0.105 Tw T* [(Indica)15(t)-32(ions and choice of)]TJ /Span<>> BDC ( )Tj EMC [(t)-13(he t)-9.9(ype of)]TJ /Span<>> BDC ( )Tj EMC [(p)25(r)-23.9(event)-32(i)-16(ve st)17(oma in pl)-15.9(anned )]TJ 0.015 Tw T* [(sur)-32(gical inter)-32(vent)-31.9(ions for r)-24(ec)-16(t)15(al cancer. )]TJ /T1_2 1 Tf 0 Tw [(K)18(olop)46(roktologia)]TJ /T1_1 1 Tf 0.015 Tw (. 2005;3:33\226)Tj 0.023 Tw T* (38. \(In Russ.\).)Tj 0.013 Tc 0.473 Tw T* (31.)Tj /Span<>> BDC ( )Tj EMC 1.847 0 Td [(S)-15.8(hell)-30.9(i)-23.8(t)17.2(o)]TJ /Span<>> BDC ( )Tj EMC [(PC. Com)10.2(pl)-30.8(ica)15.2(t)-31.9(ions of)]TJ /Span<>> BDC ( )Tj EMC [(abd)-15.9(ominal st)17.2(oma sur)-31.8(ger)-23.8(y.)13( )]TJ 0 Tc 0 Tw -1.847 -1.25 Td [(R)13(ev)-16(iew. )]TJ /T1_2 1 Tf 0.057 Tw 3.403 0 Td [(Dis Colon R)21.1(ectum.)]TJ /T1_1 1 Tf [( 1998 Dec;41\(12\):1562\22672. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1007/)Tj -3.403 -1.25 Td (BF02237308)Tj 0 0 0 1 k /GS1 gs 0.146 Tw T* (32.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Mur)-23.9(k)10(en)]TJ /Span<>> BDC ( )Tj EMC (DR, Bleier)Tj /Span<>> BDC ( )Tj EMC [(JIS. Ost)17.1(omy-R)13(el)-16(a)15(ted Com)10(pl)-30.9(ica)15(t)-32(ions. R)13(ev)-16(iew. )]TJ /T1_2 1 Tf 0.233 Tw -1.796 -1.25 Td [(Clin Colon R)21(ectal Surg)]TJ /T1_1 1 Tf [(. 2019 Ma)15.1(y;32\(3\):176\226182. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1055/s-)Tj T* (0038-1676995)Tj 0 0 0 1 k /GS1 gs 0.023 Tw [( Epub 2019 Ap)25(r 2.)]TJ 0.015 Tc 0.562 Tw T* (33.)Tj /Span<>> BDC ( )Tj EMC 1.857 0 Td [(S)-16.4(habbir)]TJ /Span<>> BDC ( )Tj EMC 3.972 0 Td [(J, )0.5(Br)-37.3(i)-24.3(t)-30.4(t)16.7(on)]TJ /Span<>> BDC ( )Tj EMC 5.33 0 Td [(DC. )0.5(S)14.7(t)16.6(oma )0.6(com)9.7(pl)-31.3(ica)14.7(t)-32.4(ions: )0.5(a)]TJ /Span<>> BDC ( )Tj EMC 13.811 0 Td [(l)-31.3(i)-24.4(ter)-33.3(a)]TJ 0 Tc 0 Tw (-)Tj 0.001 Tc 0.349 Tw -24.971 -1.25 Td [(tur)-23.8(e over)-31.8(v)-15.8(iew. R)13.1(ev)-15.8(iew. )]TJ /T1_2 1 Tf (Colorectal Dis)Tj /T1_1 1 Tf [(. 2010 O)-15.9(c)-15.8(t;12\(10\):958\22664.)1( )]TJ 0 Tc 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1111/j.1463-1318.2009.02006.x)Tj 0 0 0 1 k /GS1 gs -0.008 Tw -1.847 -1.25 Td (34.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(V)29(o)-16(gel)]TJ /Span<>> BDC ( )Tj EMC 2.438 0 Td [(I, )0.5(S)-16(hink)-24(win)]TJ /Span<>> BDC ( )Tj EMC 4.703 0 Td [(M, )0.5(v)-15(an der )0.5(S)15(t)17(or)-16(m)]TJ /Span<>> BDC ( )Tj EMC 6.808 0 Td [(SL, e)-11.9(t)]TJ /Span<>> BDC ( )Tj EMC [(al. )0.5(O)-24(ver)-33(all )0.5(r)-24(eadmissions )]TJ 0.005 Tw -15.745 -1.25 Td [(and r)-24(eadmissions r)-24(el)-15.9(a)15(ted t)17(o)]TJ /Span<>> BDC ( )Tj EMC [(dehydr)-32.9(a)15(t)-32(ion af)-28(ter cr)-24(ea)15(t)-32(ion of)]TJ /Span<>> BDC ( )Tj EMC [(an ileost)17(o)]TJ 0 Tw (-)Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\007\003\032)50(\n\n\217\n)-21(\035\030\002)]TJ 53.418 0 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( )Tj EMC [(V)51.1(.)]TJ /Span<>> BDC 0.869 0 Td ( )Tj EMC [(C)1.2(he)-3.7(r)-16.6(n)4.2(y)-3(s)7.6(ho)-2.6(v)31.6(,)-2( )]TJ 0.001 Tc -0.001 Tw -17.421 -1.218 Td [(E)21.6(v)9.2(g)-1.5(e)-1.6(n)7.2(y)]TJ /Span<>> BDC 2.704 0 Td ( )Tj EMC (G.)Tj /Span<>> BDC 1.041 0 Td ( )Tj EMC [(R)-8(y)7.9(b)0.6(a)2.7(k)13.9(ov)]TJ /T1_0 1 Tf 0 Tc 1.014 Tw -3.745 -1.218 Td [(C)-6.5(o)-5.8(l)-19(l)-14.3(e)-9.4(c)-32.5(t)-37.3(i)3.2(o)0.8(n )0.5(a)2.4(n)-4.6(d )0.6(p)-3.8(r)-6(o)-7(ce)-13.3(s)-12.8(s)-16.6(i)7.1(n)-1.9(g )0.6(o)-2.2(f)]TJ /Span<>> BDC ( )Tj EMC 15.798 0 Td [(t)-16.7(h)-5.3(e )0.6(m)1.8(a)-8.4(t)-15.2(e)-2.1(r)-48(i)5.1(a)-1.5(l)-22.5(:)]TJ /T1_3 1 Tf 0 Tw ( )Tj -15.798 -1.218 Td [(Y)33.7(u)2.8(l)4.3(i)5.9(a)]TJ /Span<>> BDC ( )Tj EMC [(A)-12.6(.)]TJ /Span<>> BDC ( )Tj EMC [(E)19.6(l)10.4(\244)8.9(m)-1.1(o)-0.6(v)10.8(a)]TJ /T1_0 1 Tf -0.007 Tc 1.521 Tw 0 -1.218 TD [(St)-34.7(a)-15.4(t)-44.4(i)-4.3(s)-27(t)-44.4(i)-1.8(c)-18.8(a)-8.5(l)-7( p)-10.8(r)-13(o)-14(c)-6.8(e)-20.3(s)-19.8(s)-23.6(in)-8.9(g)2(:)]TJ /T1_3 1 Tf 0 Tc 1.514 Tw 10.602 0 Td [( Y)33.7(u)2.8(l)4.3(i)5.9(a)]TJ /Span<>> BDC ( )Tj EMC [(A)-12.6(.)]TJ /Span<>> BDC ( )Tj EMC [(E)19.6(l)10.4(\244)8.9(m)-1.1(o)-0.6(v)10.8(a)-14(, )]TJ -0.01 Tc 0.01 Tw -10.602 -1.218 Td [(Ra)-13(sh)-3.8(i)-6.9(d)]TJ /Span<>> BDC 2.583 0 Td ( )Tj EMC [(I)-7.6(.)]TJ /Span<>> BDC 0.864 0 Td ( )Tj EMC [(F)15.4(a)-15.9(y)-12.4(z)3(u)-7.2(l)-5.7(i)-1.6(n)]TJ /T1_0 1 Tf 0 Tc 0 Tw -3.447 -1.218 Td [(W)3.1(r)-48(i)-6(t)-37.4(i)7.1(n)-1.9(g o)-2.2(f)]TJ /Span<>> BDC ( )Tj EMC [(t)-16.7(h)-5.3(e t)-15.2(e)-23.9(x)-36(t)-20(:)]TJ /T1_3 1 Tf [( Y)33.7(u)2.8(l)4.3(i)5.9(a)]TJ /Span<>> BDC ( )Tj EMC [(A)-12.5(.)]TJ /Span<>> BDC ( )Tj EMC [(E)19.6(l)10.4(\244)8.9(m)-1.1(o)-0.6(v)10.8(a)]TJ /T1_0 1 Tf 0.006 Tc -0.006 Tw 0 -1.218 TD [(E)11.6(dit)-31.4(i)13.1(n)4.1(g)15(:)]TJ /T1_3 1 Tf 0 Tc 0.298 Tw 3.238 0 Td [( S)16.3(t)2.3(a)-0.8(n)6.2(i)11(s)9.3(l)3.3(a)-4.3(v)]TJ /Span<>> BDC ( )Tj EMC [(V)53.1(.)]TJ /Span<>> BDC ( )Tj EMC [(C)3.2(h)1.9(e)-1.7(r)-14.6(n)6.2(y)-1(s)9.6(h)1.9(o)-0.6(v)33.6(, E)20.6(v)8.2(g)-2.5(e)-2.6(n)6.2(y)]TJ /Span<>> BDC ( )Tj EMC [(G)-1.3(.)]TJ /Span<>> BDC ( )Tj EMC [(R)-9(y)6.9(ba)1.7(k)12.9(o)-0.6(v)33.6(, )]TJ -0.01 Tc 0.01 Tw -3.238 -1.218 Td [(Ra)-13(sh)-3.8(i)-6.9(d)]TJ /Span<>> BDC 2.583 0 Td ( )Tj EMC [(I)-7.6(.)]TJ /Span<>> BDC 0.864 0 Td ( )Tj EMC [(F)15.4(a)-15.9(y)-12.4(z)3(u)-7.2(l)-5.7(i)-1.6(n)]TJ /T1_2 1 Tf 0 Tc 0.023 Tw -3.447 -2.436 Td (\255\026\036\031\036\025\034\226 \017\223 \032\026\020\017\022\032\225 \(\ ORCID\))Tj /T1_0 1 Tf 0.461 Tw 0 -1.218 TD [(\213\035\235\017\n\024\r\026 )0.6(\222.\202)]TJ /Span<>> BDC ( )Tj EMC 7.187 0 Td [(\227 )0.5(\022\035\017\027\017\004\036\f\022\017\005 )0.5(\024\030\007\017\027\026\021\024\030 )0.5(\205\206\207\211 )]TJ 0.864 Tw -7.187 -1.218 Td (\253\203\204\236\037 \022\024\035\024\023\030\024\022\021\024\035\024\020\ \017\017 \017\n\036\027\017 \202.\203. \217\t\032\017\b\273 )Tj 0 Tw T* (\204\017\027\007\030\026\r\026 \217\024\f\f\017\017; ORCID 0009-0007-33\ 16-7041)Tj -0.004 Tw T* (\205\026\005\031\035\017\027 \217.\236.)Tj /Span<>> BDC ( )Tj EMC (\227 \026\f\023\017\030\026\027\021 \205\206\207\211 \253\203\204\236\037\ \022\024\035\024\023\030\024\022\021\024)Tj 0 Tw (-)Tj 0.088 Tw T* (\035\024\020\017\017 \017\n\036\027\017 \202.\203. \217\t\032\017\b\273 \ \204\017\027\007\030\026\r\026 \217\024\f\f\017\017; ORCID )Tj 0 Tw T* (0000-0003-0719-7910)Tj -0.042 Tw T* (\232\036\030\027\t\001\024\r \224.\200.)Tj /Span<>> BDC ( )Tj EMC (\227 \007.\n.\027., \026\r\036\007\031\033\013\017\005 \024\021\007\036\ \035\036\027\017\036\n \n\026)Tj 0 Tw (-)Tj 0.174 Tw T* [(\035\024\017\027\r\026\017\r\027\024\005 )0.5(\024\027\022\024\023\030\024\022\021\024\035\024\020\017\017 \205\206\207\ \211 \253\203\204\236\037 \022\024\035\024)]TJ 0 Tw (-)Tj 0.08 Tw T* (\023\030\024\022\021\024\035\024\020\017\017 \017\n\036\027\017 \202.\203\ . \217\t\032\017\b\273 \204\017\027\007\030\026\r\026 \217\024\f\f\017\017\ ; )Tj 0 Tw T* (ORCID 0000-0002-6212-9454)Tj 0.234 Tw T* (\217\t\002\026\022\024\r \213.\206.)Tj /Span<>> BDC ( )Tj EMC 5.974 0 Td [(\227 \007.\n.\027., )0.5(\023\030\024\235\036\f\f\024\030 \217\202\203, )0.5(\030\031\022\024\r\024\007\017)]TJ 0 Tw (-)Tj 0.549 Tw -5.974 -1.218 Td (\021\036\035\034 \024\021\007\036\035\026 \024\027\022\024\023\030\024\022\ \021\024\035\024\020\017\017 \253\203\204\236\037 \022\024\035\024\023\030\ \024\022)Tj 0 Tw (-)Tj 0.473 Tw T* (\021\024\035\024\020\017\017 \017\n\036\027\017 \202.\203. \217\t\032\017\ \b\273 \204\017\027\007\030\026\r\026 \217\024\f\f\017\017; )Tj 0 Tw T* (ORCID)Tj /Span<>> BDC ( )Tj EMC (0000-0002-3919-9067)Tj /T1_2 1 Tf 0.023 Tw 0 -2.436 TD (INFORMATION ABOUT THE)Tj /Span<>> BDC ( )Tj EMC (AUTHORS \(ORCID\))Tj /T1_0 1 Tf 0 Tw 0 -1.218 TD [(Y)35(ul)-31(ia A. El\251mov)-14.9(a)]TJ /Span<>> BDC ( )Tj EMC (\227 0009-0007-3316-7041)Tj T* [(R)-10(ashid I. F)20.1(a)15(yzul)-31(in)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0003-0719-7910)Tj T* [(S)15(t)15(anisl)-16(av V. Cher)-14.9(ny)-12.9(shov)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0002-6212-9454)Tj T* [(Ev)-21(geny G. R)-19.9(ybakov)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0002-3919-9067)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 70.936 188.9979 Tm [(\r\031\024\034\033)48(\026)45(\024)-10(\223\033)48(\026/REFERENCES)]TJ 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0 Tc -0.012 Tw 8 0 0 8 70.8661 176.1632 Tm (1.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (\202\035\036\022\f\036\036\r)Tj /Span<>> BDC ( )Tj EMC (\204.\200. \203\036\f\024\f\021\024\016\021\036\035\034\027\024\f\021\034\ \022\024\035\024\030\036\022\021\026\035\034\027\024\020\024 \026\027\026\ \f\021\024\n\024\026: )Tj 0.139 Tw -1.296 -1.25 Td (\235\026\022\021\024\030\t \030\017\f\022\026, \023\030\024\020\027\024\ \017\030\024\r\026\027\017\036 \017)Tj /Span<>> BDC ( )Tj EMC (\n\036\021\024\007\t \023\030\024\235\017\035\026\022\021\017\022\017: \007\ \017\f\f. )Tj 0.225 Tw 0 -1.25 TD [(\252 \007-\030\026 \n\036\007. \027\026\031\022. \204\024\f\022\r\026. 2\ 020; 198 \f./ Alek)-9.9(seev)]TJ /Span<>> BDC ( )Tj EMC [(M.V. F)20(ail)35(ur)-23.9(e )]TJ 0.249 Tw T* (of)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(col)30(or)-24(ec)-15.9(t)15(al )0.5(anast)17(omosis: )0.6(r)-37(isk )0.6(f)16(a)-17(c)-16(t)17(or)-9.9(s, )0.5(p)25(r)-32(o)-16(gnosis )0.6(and )0.5(p)25(r)-23.9(event)-32(ion )]TJ 0.034 Tw -1.296 -1.25 Td [(me)-12(t)-13(hods: diss. \252 d)-15.9(o)-16(c)-16(t)17(or of)]TJ /Span<>> BDC ( )Tj EMC [(medical sc)-24(iences. M)-23.9(osco)-14(w. 2020; 198)]TJ /Span<>> BDC ( )Tj EMC (p. )Tj 0.023 Tw T* (\(In Russ.\).)Tj 0.086 Tw T* (2.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Pl)-16(asenc)-23.9(ia)]TJ /Span<>> BDC ( )Tj EMC (A, Bahna)Tj /Span<>> BDC ( )Tj EMC [(H. Di)-16(ver)-21.9(t)-32(ing Ost)17(omy: F)10(or Whom, When, Wha)15(t, )]TJ 0.151 Tw -1.296 -1.25 Td [(Wher)-24(e, and Why? )]TJ /T1_3 1 Tf [(Clin Colon R)21(ectal Surg.)]TJ /T1_0 1 Tf [( 2019 Ma)15(y;32\(3\):171\226175. )]TJ 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1055/s-0038-1677004)Tj 0 0 0 1 k /GS1 gs 0.023 Tw [( Epub 2019 Ap)25(r 2.)]TJ 0.094 Tw -1.847 -1.25 Td (3.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (\204\026\021\033\001\036\027\022\024\224.\200. \224\030\026\r\027\017\021\ \036\035\034\027\t\036 \026\f\023\036\022\021\t \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\235\017\035\026\022\021\017\022\026 \027\036\f\024)Tj 0 Tw (-)Tj 0.245 Tw 27.759 11.25 Td (\f\021\024\016\021\036\035\034\027\024\f\021\017 \001\r\024\r \022\024\035\ \024\030\036\022\021\026\035\034\027\t\b \026\027\026\f\021\024\n\024\024\ \r \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\f\235\017\027\022\021\036)Tj 0 Tw (-)Tj 0.145 Tw T* [(\030\024\f\024\b\030\026\027\016\033\013\017\b )0.7(\024\023\036\030\026\006\017\016\b )0.6(\023\024)]TJ /Span<>> BDC ( )Tj EMC 13.153 0 Td [(\023\024\r\024\007\031 )0.6(\030\026\022\026 )0.5(\023\030\016\n\024\005 )0.6(\022\017\001\022\017: )0.7(\007\017\f\f. )]TJ 0.313 Tw -13.153 -1.25 Td [(\252 \022\026\027\007. \n\036\007. \027\026\031\022. \217\016\026\027\034\ . 2022; 136 \f. / Ma)15(t)-10(yushenko)]TJ /Span<>> BDC ( )Tj EMC (S.V. )Tj 0.137 Tw T* [(Com)10(p)32(ar)-33(a)15(t)-32(i)-15.9(ve aspec)-16(ts and p)25(r)-24(event)-31.9(ion of)]TJ /Span<>> BDC ( )Tj EMC [(sutur)-24(e f)16(ail)35(ur)-23.9(e of)]TJ /Span<>> BDC ( )Tj EMC [(col)30(or)-24(ec)-16(t)15(al )]TJ 0.2 Tw T* [(anast)17(omoses in sphinc)-16(ter-p)25(r)-24(eser)-31.9(v)-16(ing oper)-33(a)15(t)-31.9(ions for r)-24(ec)-16(t)15(al cancer: )]TJ 0.023 Tw T* (diss. ... \fand. of)Tj /Span<>> BDC ( )Tj EMC [(medic)-23.9(ine. R)-20(y)22(a)-24(zan. 2022; 136)]TJ /Span<>> BDC ( )Tj EMC (p.)Tj /Span<>> BDC ( )Tj EMC (\(In Russ.\).)Tj 0.052 Tw T* (4.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(P)40(aun)]TJ /Span<>> BDC ( )Tj EMC [(BC, S)-24(co)17.1(t)-30(t)]TJ /Span<>> BDC ( )Tj EMC [(C, Ma)-17(cL)35(ean)]TJ /Span<>> BDC ( )Tj EMC [(AR, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. P)10(ost)17(oper)-32.9(a)14.9(t)-31.9(i)-16(ve com)10(pl)-30.9(ica)15(t)-32(ions )]TJ 0.012 Tw -1.296 -1.25 Td [(foll)30(o)-14(wing sur)-31.9(ger)-24(y for r)-24(ec)-16(t)15(al cancer. )]TJ /T1_3 1 Tf (Ann Surg. )Tj /T1_0 1 Tf [(2010 Ma)15(y;251\(5\):807\226)]TJ 0.023 Tw T* [(18. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw [(10.1097/SL)-35(A.0b013e3181d)42(ae4ed)]TJ 0 0 0 1 k /GS1 gs 0.252 Tw T* (5.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (\215\024\035\017\013\031\022)Tj /Span<>> BDC ( )Tj EMC (\214.\210., \200\036\021\001\036\r)Tj /Span<>> BDC ( )Tj EMC (\205.\215., \215\036\021\030\036\027\022\024)Tj /Span<>> BDC ( )Tj EMC (\025.\203., \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. \202\027\026\035\017 )Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 0 Tw 7.5 0 0 7.5 70.8661 759.8869 Tm [(\007\003\032)50(\n\n\217\n)-21(\035\030\002)]TJ 53.418 0 Td [(MET)30(A)-41(-)-41.9(ANAL)30(Y)30(SIS)]TJ -53.418 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 2)69(4, \023\0224, 202)23(5)]TJ 43.013 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 2)69(4, \023\0224, 202)23(5)]TJ /T1_5 1 Tf 25 0 0 25 20.8652 56.0378 Tm (164)Tj ET endstream endobj 1315 0 obj <>/Border[0 0 0]/H/N/Rect[85.6442 103.459 168.3 94.1632]/Subtype/Link/Type/Annot>> endobj 1316 0 obj <>/Border[0 0 0]/H/N/Rect[330.503 103.459 437.327 94.1632]/Subtype/Link/Type/Annot>> endobj 1318 0 obj <> endobj 1317 0 obj <> endobj 1234 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\034\201\016\r\016\215\026\021\r\215\001\004 \017\021\020\016\f\215\001\004\ \b)-10(\026)11(\025\024\001: \021\t\016\025\b)-9.9(\026)10.9(\025\024\001, \017)10(\025\t\025\b)-10(\026)11(\025\024\001. \037)40.9(\001\017)10.1(\025\207 \r\001\201\021\001\215\026 )]TJ 0 -1 TD [(\235\016\213\025\222\001\b\215\016\016? \(\024\016\026)11(\001\001\215\001\t\021\213\022\021\022\b\021\b)-10(\026)11(\016\024\001\026\021\f\016\b\017\021\207 \025\235\213\025\201 \t\021\026\ )11(\016\201\001\026)-20(\200\201\220\))]TJ 41.159 1 Td [(Pr)31(e)11(v)12(entiv)12.1(e intestinal stoma: ileostom)21(y)31(, colostom)21(y)52(. )]TJ -4.661 -1 Td [(W)30(hich\022option\022is\022safer? \(meta-analy)10(sis and s)10(y)10(stematic r)31(e)11(vie)11(w\))]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf -0.015 Tw 10 0 0 10 42.5197 724.8299 Tm (\031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC [(\017\035\036\024\f\021\024\n\024\005 \017\n\036\036\021\f\016 \021\036\027\ \007\036\027\006\017\016 )0.5(\022)]TJ /Span<>> BDC ( )Tj EMC (\002\024\035\036\036 )Tj 0.013 Tw 0 -1.218 TD (\004\026\f\021\024\n\031 \r\024\027\017\022\027\024\r\036\027\017\033 \023\ \036\030\017\f\021\024\n\026\035\034\027\024\020\024 \007\036\030\n\026\021\ \017\021\026, )Tj 0.009 Tw T* (\027\036\032\036\035\017 \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\022\024\035\024\f\021\024\n\024\005 \()Tj /T1_2 1 Tf 0 Tw (\033)Tj /T1_1 1 Tf 0.009 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,08\) [36]. \225\021\024 )Tj -0.023 Tw T* [(\f\r\016\026\027\024 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC [(\002\024\035\034\001\036\005 )0.5(\f\021\036\023\036\027\017 \f)]TJ /Span<>> BDC ( )Tj EMC 12.1 0 Td [(\023\024\007\021\036\022\026\027\017\036\n )0.5(\022\017\001\036\004\027\024\020\024 )]TJ 0.013 Tw -12.1 -1.218 Td (\024\021\007\036\035\016\036\n\024\020\024 \017\035\036\024\f\021\024\n\t\ , \f\024\007\036\030\032\026\013\036\020\024 \026\022\021\017\r\027\t\036\ \023\030\024)Tj 0 Tw (-)Tj 0.217 Tw T* (\021\036\024\035\017\021\017\004\036\f\022\017\036 \235\036\030\n\036\027\ \021\t \023\024\007 \026\007\020\036\017\r\027\031\033 \023\035\026\f\021\ \017\027\031 )Tj -0.036 Tw 0 -1.218 TD (\022\026\035\024\023\030\017\036\n\027\017\022\026. \210\007\027\026\022\ \024 Du R., \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. \r)Tj /Span<>> BDC ( )Tj EMC (\f\r\024\036\005 \030\026\002\024\021\036 )Tj -0.033 Tw 0 -1.218 TD (\031\021\r\036\030\032\007\026\036\021, \004\021\024 \004\026\f\021\024\021\ \026 \r\024\027\017\022\027\024\r\036\027\017\016 \023\036\030\017\f\021\ \024\n\026\035\034)Tj 0 Tw (-)Tj 0.086 Tw T* (\027\024\020\024 \007\036\030\n\026\021\017\021\026 \f\024\023\024\f\021\ \026\r\017\n\026 \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\017\035\036\024\f\021\024)Tj 0 Tw (-)Tj T* (\n\024\005 \017)Tj /Span<>> BDC ( )Tj EMC (\022\024\035\024\f\021\024\n\024\005 \()Tj /T1_2 1 Tf (\033)Tj /T1_1 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,53\) [37].)Tj 0.258 Tw T* (\215\024 \030\036\031\035\034\021\026\021\026\n \f\030\026\r\027\017\021\ \036\035\034\027\t\b \027\036\030\026\027\007\024\n\017\017\030\024\r\026\ \027)Tj 0 Tw (-)Tj 0.196 Tw T* (\027\t\b \017\f\f\035\036\007\024\r\026\027\017\005 \031\f\021\026\027\024\ \r\035\036\027\024, \004\021\024 \007\035\016 \022\024\035\024\f\021\024\ \n\t )Tj 0.035 Tw 0 -1.218 TD (\b\026\030\026\022\021\036\030\027\024 \021\026\022\024\036 \030\026\027\ \027\036\036 \024\f\035\024\032\027\036\027\017\036, \022\026\022 \030\036\ \021\030\026\022\006\017\016 )Tj 0.213 Tw 0 -1.218 TD (\f\021\024\n\t \()Tj /T1_2 1 Tf 0 Tw (p)Tj /T1_1 1 Tf 0.213 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,0002\). \210\007\027\026\022\024, \f\024\020\035\026\f\027\024 \n\036\021\ \026\026\027\026\035\017\031, )Tj 0.052 Tw 0 -1.218 TD (\023\030\024\r\036\007\036\027\027\024\n\031 Geng)Tj /Span<>> BDC ( )Tj EMC (H.Z., \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021., \004\026\f\021\024\021\026 \r\024\027\017\022\027\024\ )Tj 0 Tw (-)Tj 0.073 Tw T* [(\r\036\027\017\016 )0.6(\030\036\021\030\026\022\006\017\017 )0.5(\f\021\024\n\t )0.5(\()]TJ /T1_2 1 Tf 0 Tw (p)Tj /T1_1 1 Tf 0.073 Tw /Span<>> BDC ( )Tj EMC 11.335 0 Td (=)Tj /Span<>> BDC ( )Tj EMC 0.805 0 Td [(0,09\) )0.5(\002\t\035\026 )0.5(\f\024\023\024\f\021\026\r\017\n\026 )]TJ 0.222 Tw -12.14 -1.218 Td (\031)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\034\027\t\b \f)Tj /Span<>> BDC ( )Tj EMC (\017\035\036\024\f\021\024\n\024\005 \017)Tj /Span<>> BDC ( )Tj EMC (\022\024\035\024\f\021\024\n\024\005, \004\021\024 \027\036\035\034\016\ )Tj 0.04 Tw T* (\f\022\026\026\021\034 \024)Tj /Span<>> BDC ( )Tj EMC (\004\026\f\021\024\021\036 \r\024\027\017\022\027\024\r\036\027\017\016\ \007\030\031\020\017\b \023\024\007\027\017\b \024\f)Tj 0 Tw (-)Tj 0.108 Tw T* (\035\024\032\027\036\027\017\005. \230\026\022, \023\030\024\035\026\023\ \f \f\021\024\n\t \()Tj /T1_2 1 Tf 0 Tw (p)Tj /T1_1 1 Tf 0.108 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,03\) \027\026\002\035\033\007\026\035)Tj 0 Tw (-)Tj 0.154 Tw T* (\f\016 \004\026\013\036 \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\022\024\035\024\f\021\024\n\024\005, \r)Tj /Span<>> BDC ( )Tj EMC (\021\024 \r\030\036\n\016, \022\026\022 )Tj 0.188 Tw T* (\004\026\f\021\024\021\026 \r\024\027\017\022\027\024\r\036\027\017\016\ \f\021\030\017\022\021\031\030\t \f\021\024\n\t \()Tj /T1_2 1 Tf 0 Tw (p)Tj /T1_1 1 Tf 0.188 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,14\) )Tj 0.141 Tw T* [(\f\021\026\021\017\f\021\017\004\036\f\022\017 )0.6(\027\026\004\017\n\024 )0.5(\027\036 )0.6(\030\026\035\017\004\026\035\026\f\034 )0.5(\n\036\032\007\031 )0.6(\020\030\031\023)]TJ 0 Tw (-)Tj 0.062 Tw T* [(\023\026\n\017 \023\026\006\017\036\027\021\024\r [38]. R)11(ondell)-30.9(i F. \027\026)]TJ /Span<>> BDC ( )Tj EMC (\024\f\027\024\r\036 \023\024\035\031\004\036\027)Tj 0 Tw (-)Tj 0.063 Tw T* (\027\t\b \017\n \007\026\027\027\t\b \021\026\022\032\036 \031\021\r\036\ \030\032\007\026\036\021, \004\021\024 \023\030\036\017\n\031\013\036\f\021\ \r\024 )Tj 0.071 Tw 23.244 28.009 Td (\023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\017\035\036\024\f\021\024\n\024\005 \f\r\016\026\027\024 \f)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\036\036 \027\017\022\024\005 \004\026)Tj 0 Tw (-)Tj 0.01 Tw T* (\f\021\024\021\024\005 \030\026\r\017\021\017\016 \023\024\007\027\017\ \b \024\f\035\024\032\027\036\027\017\005 \021\026\022\017\b, \022\026\022\ \023\030\024)Tj 0 Tw (-)Tj 0.095 Tw T* (\035\026\023\f \017)Tj /Span<>> BDC ( )Tj EMC (\f\021\030\017\022\021\031\030\026 \f\021\024\n\t, \004\036\n \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\022\024\035\024\f\021\024)Tj 0 Tw (-)Tj -0.033 Tw T* [(\n\024\005 [39]. \203\026\023\030\024\021\017\r, Y)49.9(ang S., \r)]TJ /Span<>> BDC ( )Tj EMC (\f\r\024\036\005 \030\026\002\024\021\036 \027\036 \r\t\016\r\017\035 )Tj 0.371 Tw T* (\f\021\026\021\017\f\021\017\004\036\f\022\017 \027\026\004\017\n\t\b \030\ \026\035\017\004\017\005 \r)Tj /Span<>> BDC ( )Tj EMC (\004\026\f\021\024\021\036 \030\026)Tj 0 Tw (-)Tj 0.124 Tw T* (\r\017\021\017\016 \f\021\030\017\022\021\031\030\t \017\035\036\024\f\021\ \024\n\t \017)Tj /Span<>> BDC ( )Tj EMC (\022\024\035\024\f\021\024\n\t \()Tj /T1_2 1 Tf 0 Tw (\033)Tj /T1_1 1 Tf 0.124 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,89\), )Tj 0.326 Tw 0 -1.218 TD (\024\007\027\026\022\024 \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\022\024\035\024\f\021\024\n\024\005 \r\024\027\017\022\027\024\r\036\027\ \017\036 )Tj 0.225 Tw 0 -1.218 TD (\030\036\021\030\026\022\006\017\017 \()Tj /T1_2 1 Tf 0 Tw (p)Tj /T1_1 1 Tf 0.225 Tw /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (0,01\) \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\035\026\023\f\026 \f\021\024\n\t \()Tj /T1_2 1 Tf 0 Tw (p)Tj /T1_1 1 Tf 0.225 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,01\) )Tj 0.361 Tw T* (\027\026\002\035\033\007\026\035\024\f\034 \027\026\004\017\021\036\035\ \034\027\024 \004\026\013\036, \004\036\n \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r )Tj 0 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\017\035\036\024\f\021\024\n\024\005)Tj /Span<>> BDC ( )Tj EMC ([36].)Tj 0.268 Tw T* [(\211\004\017\021\t\r\026\016, )0.6(\004\021\024 )0.5(\023\030\024\006\036\f\f )0.6(\r\t\002\024\030\026 )0.5(\r\017\007\026 )0.5(\023\030\036\r\036\027\021\017\r\027\024\005 )]TJ 0.273 Tw T* (\f\021\024\n\t \007\024\f\021\026\021\024\004\027\024 \f\035\024\032\036\ \027, \r)Tj /Span<>> BDC ( )Tj EMC (\035\017\021\036\030\026\021\031\030\036 \f\021\026\035\017 \023\024)Tj 0 Tw (-)Tj 0.498 Tw 0 -1.218 TD [(\016\r\035\016\021\034\f\016 \017\f\f\035\036\007\024\r\026\027\017\016,\ )0.5(\027\026\023\030\026\r\035\036\027\027\t\036 \027\026)]TJ /Span<>> BDC ( )Tj EMC (\017\031\004\036)Tj 0 Tw (-)Tj 0.27 Tw 0 -1.218 TD (\027\017\036 \017)Tj /Span<>> BDC ( )Tj EMC (\r\027\036\007\030\036\027\017\036 \023\036\030\f\024\027\017\235\017\006\ \017\030\024\r\026\027\027\024\020\024 \023\024\007\b\024\007\026. )Tj 0.14 Tw 0 -1.218 TD (\230\026\022, \f)Tj /Span<>> BDC ( )Tj EMC (\006\036\035\034\033 \r\024\n\024\032\027\024\020\024 \235\024\030\n\017\ \030\024\r\026\027\017\016 \017\035\036\024\f\021\024\n\t )Tj 0.292 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\023\030\036\007\031\023\030\036\032\007\036\027\017\016 \r\024\027\017\ \022\027\024\r\036\027\017\016 \024\002\036\r\024\032\017\r\026\027\017\ \016, )Tj 0.44 Tw T* (\023\026\006\017\036\027\021\026\n \027\026)Tj /Span<>> BDC ( )Tj EMC (\007\024\024\023\036\030\026\006\017\024\027\027\024\n \220\021\026\023\036\ \023\035\026\027\017\030\024\r\026)Tj 0 Tw (-)Tj 0.197 Tw T* (\035\024\f\034 \023\030\024\r\036\007\036\027\017\036 \002\017\024\023\f\ \017\017 \f\035\017\017\f\021\024\005 \021\024\027\022\024\005 \022\017\ \001\022\017 )Tj 0.366 Tw T* (\007\035\016 \017\031\004\036\027\017\016 \n\024\030\235\024\035\024\020\ \017\004\036\f\022\017\b \023\030\036\007\017\022\021\024\030\024\r \030\ \026)Tj 0 Tw (-)Tj 0.207 Tw T* (\r\017\021\017\016 \024\002\036\r\024\032\017\r\026\027\017\016 \017)Tj /Span<>> BDC ( )Tj EMC (\023\024\r\021\024\030\027\024\005 \020\024\f\023\017\021\026\035\017\026\ \006\017\017 )Tj 0.103 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\023\024\f\035\036\007\031\033\013\036\n [40], \024\007\027\026\022\024 \ \021\026\022\024\005 \023\024\007\b\024\007 \r\t\020\035\016\007\017\021\ )Tj 0.415 Tw T* (\022\030\026\005\027\036 \f\024\n\027\017\021\036\035\034\027\024 \017)Tj /Span<>> BDC ( )Tj EMC (\027\036\024\007\027\024\027\026\004\027\024. \224\021\024\017\021 \f\022\ \026)Tj 0 Tw (-)Tj 0.254 Tw T* (\026\021\034, \004\021\024 \f\031\013\036\f\021\r\031\033\021 \023\030\036\ \017\n\031\013\036\f\021\r\026 \235\024\030\n\017\030\024\r\026\027\017\016\ )Tj 0.212 Tw T* (\022\024\035\024\f\021\024\n\t, \021\026\022 \022\026\022 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\n \017\n\036\036\021\f\016 \r\024\n\024\032\027\024\f\021\034\ )Tj ET q /GS0 gs 453.543294 0 0 131.0236183 42.5196838 293.9133935 cm /Im0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0 Tw 9 0 0 9 42.5197 283.1134 Tm (\022\t\217\210\b\002\220 15\032.)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf ( \r\022\001\016\005\020\037\030 \020\016\f\033\034\002\034\b\022\006\034\ \024\035\003. \213\016\031\023\027\003\035\037\035\032 \033\037\020\b\034\ \006\022\031\022\033\034\036\037\020\020\032\002 \022\024\024\027\016\b\034\ \036\037\020\022\004)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0 -1.2 TD [(F)-16(igure 1)93.1(5A)-15(.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf [( Ileus. R)21.1(esults of)]TJ /Span<>> BDC ( )Tj EMC [(randomized tr)-36.8(ials)]TJ ET q 42.52 101.029 453.543 160.78 re W n q /GS0 gs 453.543294 0 0 160.7798979 42.5196838 101.0295504 cm /Im1 Do Q Q BT 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 9 0 0 9 42.5197 90.1701 Tm (\022\t\217\210\b\002\220 15\223.)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf ( \r\022\001\016\005\020\037\030 \020\016\f\033\034\002\034\b\022\006\034\ \024\035\003. \213\016\031\023\027\003\035\037\035\032 \024\033\037\036\020\ \022\035\016\027\003\020\032\002 \020\016\033\037\020\b\034\006\022\031\022\ \033\034\036\037\020\020\032\002 \022\024\024\027\016\b\034\036\037\020\022\ \004)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf T* [(F)-16(igure 1)93.1(5B.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf [( Ileus. R)21.1(esults of)]TJ /Span<>> BDC ( )Tj EMC [(com)16.1(parativ)13(e non-randomized tr)-36.8(ials)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\007\003\032)50(\n\n\217\n)-21(\035\030\002)]TJ 53.418 0 Td [(MET)30(A)-41(-)-41.9(ANAL)30(Y)30(SIS)]TJ /T1_4 1 Tf 25 0 0 25 505.4895 56.0378 Tm (163)Tj ET endstream endobj 1235 0 obj <>stream Adobed     '$''''$25552;;;;;;;;;;   %%#(((((#,0000,7;;;7;;;;;;;;;;   %%#(((((#,0000,7;;;7;;;;;;;;;;   %%#(((((#,0000,7;;;7;;;;;;;;;;<""  !1"AQ #$%&'()*23456789:BCDEFGHIJRSTUVWXYZabcdefghijqrstuvwxyz}!1AQaq"2bB#RU $%&'()*3456789:CDEFGHIJSTVWXYZcdefghijrstuvwxyz?"D@DD@DD@DD@DD@DD@DD@DD@DD@DD@DD@[1{Z J ( Šͱ&UoCav gSe`\dusml[kvJwDvx/H~6{"c2cz>ϣ=pun5[ŧT(:ɤ0_ 1 웑TCJ:F+T{IƜCmV nbZ+F|fW QJj 508`ɤ{jN/fvfku< TI %zW_ ni *8x*q+۴MGv\ "%bc^ &H{/U5+z%M7Sdey)pp3-#j*6B"J /$toA1e/DqN-*kb):mC}Ơ"" "ݑڍľhZ&w#|hڞ"m-Oۮuz-Lw.m=tt" ~5K_K#NQi0`_Cƭx)%7NRTY5m;0;rx/D앱[/Kl5^s ]:V#ⰵP8w)NnOxB"󝣲[.:8nԩI  ; y \ ezWG Sw]\7&ǯ&(mg4>E /-,pZ@ׂɦ2#9+jbS 芣w@a -/ ̞7W8| x'ilPq4K\:Ŗ== 4὆Zx d=MUe,5*Tp kDJ 0ԫTmJ8 VB:@\ 3PZ^%_'6:1Fj>;ԎdƒGgKK Diu17=Kba\}:]ӻ ^[RSSkV:Sq9r608Zm}jvj8=sTAESdbvN-::{C=-0AlWc-mm(Vokh5h[Fx|E UZwpfΊ{Pv'n0c^Gy[h/Ůty& Z%DЪ"E>NlmÈ=)9v{Lyc6n;x MuFVuj$;0g%K=m*< fF*J[F8;ֆc=2Hq ;[)bjӣxgaEOcK?~wZ ෫zTU}JS<6s:+[Gb;@b kƎc]\tEk7<.⺻/{^7baRi 2 PcX7fT6 j|Ffڕ[?+0d{w)t|3_]CJ *_qX3WN]VvL`&sobiҧBw1; fb-"_o&;,{{#^֙tX sf? 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\027\036\f\024\f\021\024\016\021\036\035\034\027\024\f\021\ \017 \022\024\035\024\030\036\022\021\026\035\034\027\024\020\024 \026\027\ \026\f\021\024)Tj 0 Tw (-)Tj 0.03 Tw T* (\n\024\026 \r)Tj /Span<>> BDC ( )Tj EMC (\f\035\031\004\026\036 \036\036 \r\024\027\017\022\027\024\r\036\027\017\ \016, \026)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\032\036 \r\024\n\024\032\027\t\036 )Tj 0.275 Tw 0 -1.218 TD (\024\f\035\024\032\027\036\027\017\016, \f\r\016\026\027\027\t\036 \023\ \024\f\035\036 \235\024\030\n\017\030\024\r\026\027\017\016 \f\021\024\n\ )Tj 0.044 Tw 0 -1.218 TD (\017)Tj /Span<>> BDC ( )Tj EMC (\r\t\023\024\035\027\036\027\017\036\n \030\036\022\024\027\f\021\030\031\ \022\021\017\r\027\024-\r\024\f\f\021\026\027\024\r\017\021\036\035\034\027\ \t\b )Tj 0 Tw 0 -1.218 TD (\024\023\036\030\026\006\017\005 \f)Tj /Span<>> BDC ( )Tj EMC (\035\017\022\r\017\007\026\006\017\036\005 \f\021\024\n.)Tj 0.155 Tw 0 -1.218 TD (\224\035\036\007\031\036\021 \024\021\n\036\021\017\021\034, \004\021\024\ \023\024\035\031\004\036\027\027\t\036 \030\036\031\035\034\021\026\021\ \t \016\r\035\016)Tj 0 Tw (-)Tj -0.012 Tw 0 -1.218 TD (\033\021\f\016 \007\024\f\021\026\021\024\004\027\024 \024\032\017\007\026\ \036\n\t\n\017. \230\026\022, \031\f\035\024\r\027\024 \030\026\007\036\ \035\017\r )Tj 0.072 Tw 0 -1.218 TD (\024\f\035\024\032\027\036\027\017\016 \017\035\036\024\f\021\024\n \017\ )Tj /Span<>> BDC ( )Tj EMC (\022\024\035\024\f\021\024\n \027\026)Tj /Span<>> BDC ( )Tj EMC (\030\026\027\027\017\036 \017)Tj /Span<>> BDC ( )Tj EMC (\023\024\007)Tj 0 Tw (-)Tj 0.036 Tw 0 -1.218 TD (\027\017\036, \031\007\026\035\024\f\034 \031\f\021\026\027\024\r\017\021\ \034, \004\021\024 \023\036\030\r\t\036 \002\024\035\036\036 \b\026\030\026\ \022\021\036\030)Tj 0 Tw (-)Tj 0.083 Tw 0 -1.218 TD [(\027\t )0.5(\007\035\016 )0.5(\017\035\036\024\f\021\024\n, )0.5(\026)]TJ /Span<>> BDC ( )Tj EMC (\r\021\024\030\t\036)Tj /Span<>> BDC ( )Tj EMC 11.582 0 Td [(\227 \007\035\016 )0.5(\022\024\035\024\f\021\024\n. )0.5(\025\030\026\005\027\036 )]TJ 0.284 Tw 11.662 23.138 Td (\017\027\021\036\030\036\f\027\024, \004\021\024 \220\021\017 \007\026\027\ \027\t\036 \f\024\r\023\026\007\026\033\021 \f)Tj /Span<>> BDC ( )Tj EMC (\030\036\031\035\034\021\026)Tj 0 Tw (-)Tj 0.252 Tw T* (\021\026\n\017 \022\026\022 \030\026\027\007\024\n\017\017\030\024\r\026\ \027\027\t\b, \021\026\022 \017)Tj /Span<>> BDC ( )Tj EMC (\027\036\030\026\027\007\024\n\017\017)Tj 0 Tw (-)Tj 0.174 Tw T* (\030\024\r\026\027\027\t\b \017\f\f\035\036\007\024\r\026\027\017\005, \023\ \030\024\r\024\007\017\n\t\b \036\013\036 \r)Tj /Span<>> BDC ( )Tj EMC (\027\026\004\026\035\036 )Tj 0 Tw T* (21)Tj /Span<>> BDC ( )Tj EMC (\r\036\022\026)Tj /Span<>> BDC ( )Tj EMC ([31\22633].)Tj -0.014 Tw T* (\230\026\022, \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\027\026\035\017\004\017\017 \017\035\036\024\f\021\024\n\t \f\031\013\036\ \f\021\r\031\036\021 \030\017\f\022 \r\024\027\017\022)Tj 0 Tw (-)Tj -0.06 Tw T* (\027\024\r\036\027\017\016 \024\002\036\r\024\032\017\r\026\027\017\016\ \()Tj /T1_2 1 Tf 0 Tw (\033)Tj /T1_1 1 Tf -0.06 Tw /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (0,00001\), \022\024\021\024\030\024\036 \r\035\036\004\036\021 )Tj 0.16 Tw T* (\026)Tj /Span<>> BDC ( )Tj EMC (\f\024\002\024\005 \027\026\030\031\001\036\027\017\036 \r\024\007\027\024\ -\220\035\036\022\021\030\024\035\017\021\027\024\020\024 \002\026\035\026\ \027\f\026 )Tj 0.301 Tw 0 -1.218 TD (\017)Tj /Span<>> BDC ( )Tj EMC (\022\026\022 \f\035\036\007\f\021\r\017\036 \027\026\004\017\021\036\035\ \034\027\024 \031\r\036\035\017\004\017\r\026\036\021 \004\026\f\021\024\ \021\031 )Tj 0.112 Tw 0 -1.218 TD (\023\024\r\021\024\030\027\t\b \020\024\f\023\017\021\026\035\017\026\006\ \017\005 [34]. \210\007\027\026\022\024 Chudner)Tj /Span<>> BDC ( )Tj EMC (A., )Tj 0.19 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. \r)Tj /Span<>> BDC ( )Tj EMC (\f\r\024\036\005 \030\026\002\024\021\036 \027\036 \r\t\016\r\017\035\017\ \f\021\026\021\017\f\021\017\004\036\f\022\017 )Tj 0.264 Tw T* [(\027\026\004\017\n\t\036 )0.6(\030\026\035\017\004\017\016 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 9.851 0 Td [(\004\026\f\021\024\021\036 )0.6(\r\024\027\017\022\027\024\r\036\027\017\016 )0.5(\024\002\036)]TJ 0 Tw (-)Tj 0.045 Tw -9.851 -1.218 Td [(\r\024\032\017\r\026\027\017\016 )0.5(\031)]TJ /Span<>> BDC ( )Tj EMC [(\023\026\006\017\036\027\021\024\r )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC [(\017\035\036\024\f\021\024\n\024\005 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC (\022\024\035\024\f\021\024\n\024\005 )Tj 0 Tw 0 -1.218 TD (\()Tj /T1_2 1 Tf (p)Tj /T1_1 1 Tf 0.157 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,13\), \027\024 \024\021\n\036\021\017\035\017, \004\021\024 \004\026\f\ \021\024\021\026 \r\024\027\017\022\027\024\r\036\027\017\016 )Tj 0.131 Tw 0 -1.218 TD (\023\024\004\036\004\027\024\005 \027\036\007\024\f\021\026\021\024\004\027\ \024\f\021\017 \027\026\004\017\021\036\035\034\027\024 \r\t\001\036 \023\ \024\f\035\036 )Tj 0.236 Tw 0 -1.218 TD (\235\024\030\n\017\030\024\r\026\027\017\016 \017\035\036\024\f\021\024\n\ \t \()Tj /T1_2 1 Tf 0 Tw (p)Tj /T1_1 1 Tf 0.236 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,005\) [35]. \230\026\022\032\036, )Tj 0.613 Tw 0 -1.218 TD (\f\024\020\035\026\f\027\024 \023\024\035\031\004\036\027\027\t\n \030\036\ \031\035\034\021\026\021\026\n, \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r )Tj -0.019 Tw 0 -1.218 TD (\f)Tj /Span<>> BDC ( )Tj EMC (\017\035\036\024\f\021\024\n\024\005 \r\036\030\024\016\021\027\024\f\021\ \034 \030\026\r\017\021\017\016 \023\036\030\017\f\021\024\n\026\035\034\ \027\024\020\024 )Tj 0.109 Tw 0 -1.218 TD [(\007\036\030\n\026\021\017\021\026 )0.5(\r\t\001\036, )0.6(\004\036\n )0.5(\031)]TJ /Span<>> BDC ( )Tj EMC 9.97 0 Td [(\023\026\006\017\036\027\021\024\r )0.6(\f)]TJ /Span<>> BDC ( )Tj EMC 5.442 0 Td [(\022\024\035\024\f\021\024\n\024\005, )0.5(\027\036)]TJ 0 Tw (-)Tj 0.212 Tw -15.412 -1.218 Td (\f\n\024\021\030\016 \027\026)Tj /Span<>> BDC ( )Tj EMC (\024\021\f\031\021\f\021\r\017\036 \f\021\026\021\017\f\021\017\004\036\f\ \022\017 \027\026\004\017\n\t\b \030\026)Tj 0 Tw (-)Tj 0.075 Tw 0 -1.218 TD [(\035\017\004\017\005 )0.6(\()]TJ /T1_2 1 Tf 0 Tw (\033)Tj /T1_1 1 Tf 0.075 Tw /Span<>> BDC ( )Tj EMC 3.962 0 Td (=)Tj /Span<>> BDC ( )Tj EMC 0.807 0 Td [(0,06\). )0.6(\230\026\022, )0.5(Y)50(ang )0.6(S., )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC 8.833 0 Td [(\f\024\026\r\021. )0.6(\023\024\022\026\026\035\017, )0.6(\004\021\024 )]TJ ET q /GS0 gs 453.543294 0 0 131.0236183 70.8661346 342.5579247 cm /Im0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf -0.001 Tw 9 0 0 9 70.8661 331.7579 Tm (\022\t\217\210\b\002\220 14\032.)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf ( \213\037\020\016\036\037\030 \022\020\017\016\021\007\022\030 \022)Tj /Span<>> BDC ( )Tj EMC (\013\016\006\037\035\034\006\037 \f\016\033\016\b\020\016\004 \025\033\026\ \001\020\034\004 \024\035\016\020\021\022. \213\016\031\023\027\003\035\037\ \035\032 \033\037\020\b\034\006\022\031\022\033\034\036\037\020\020\032\002\ \022\024\024\027\016\b\034\036\037\020\022\004)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0 Tw 0 -1.2 TD [(F)-16(igure 1)76.1(4A)-15(.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf [( W)29(ound infection and hematoma of)]TJ /Span<>> BDC ( )Tj EMC [(the anter)-36.6(ior abdominal w)13.1(all. R)21(esults of)]TJ /Span<>> BDC ( )Tj EMC [(randomized tr)-37(ials)]TJ ET q 70.866 111.77 453.543 198.684 re W n q /GS0 gs 453.543294 0 0 198.6951574 70.8661194 111.7588221 cm /Im1 Do Q Q BT 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0.085 Tw 9 0 0 9 70.8661 100.9701 Tm (\022\t\217\210\b\002\220 14\223.)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf ( \213\037\020\016\036\037\030 \022\020\017\016\021\007\022\030 \022)Tj /Span<>> BDC ( )Tj EMC (\013\016\006\037\035\034\006\037 \f\016\033\016\b\020\016\004 \025\033\026\ \001\020\034\004 \024\035\016\020\021\022. \213\016\031\023\027\003\035\037\ \035\032 \024\033\037\036\020\022\035\016\027\003\020\032\002 \020\016\033\ \037\020\b\034\006\022\031\022\033\034)Tj 0 Tw (-)Tj T* (\036\037\020\020\032\002 \022\024\024\027\016\b\034\036\037\020\022\004)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf T* [(F)-16(igure 1)76.1(4B.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf [( W)29(ound infection and hematoma of)]TJ /Span<>> BDC ( )Tj EMC [(the anter)-36.6(ior abdominal w)13.1(all. R)21(esults of)]TJ /Span<>> BDC ( )Tj EMC [(com)16(parativ)13(e non-randomized tr)-36.9(ials)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\007\003\032)50(\n\n\217\n)-21(\035\030\002)]TJ 53.418 0 Td [(MET)30(A)-41(-)-41.9(ANAL)30(Y)30(SIS)]TJ -53.418 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 2)69(4, \023\0224, 202)23(5)]TJ 43.013 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 2)69(4, \023\0224, 202)23(5)]TJ /T1_5 1 Tf 25 0 0 25 20.7776 56.0378 Tm (162)Tj ET endstream endobj 1232 0 obj <>stream Adobed     '$''''$25552;;;;;;;;;;   %%#(((((#,0000,7;;;7;;;;;;;;;;   %%#(((((#,0000,7;;;7;;;;;;;;;;   %%#(((((#,0000,7;;;7;;;;;;;;;;<""  !"1Qa #$%&'()*23456789:ABCDEFGHIJRSTUVWXYZbcdefghijqrstuvwxyz|!1AQaq"b2B#R $%&'()*3456789:CDEFGHIJSTUVWXYZcdefghijrstuvwxyz?"D@DD@DD@DD@DD@DD@DD@DD@DD@DD@DD@[1{Z J ( Šͱ&UoCav gSe`\dusml[kvJwDvx/H~6{"c2cz>ϣ=-cNqot_V*Kdsh7!r4:[vm 7GR/B0z{vi !x@^`X$ Lkdxi/ceqoD齘@Ӧ`WO%.w*"*Z$T`QDB8~qXZ/ıʕHsR~'M­#hm^lx݄m ,ʅF"'39(jSa;W5,T)Dy@_gwMϨ 1t *3J7 /l{@ ^R] :e`ƞ;t'SKek]-%oTZO3V4"-û 1!x_/RU(2(MǾ5hk lGJEjOck2i{Ia|m|%|5gЫMͫLpB؜ %zeqթԯ cw{}L+4b6?)2VlC@ 7#p 4Eؚ{9I۽ 'J\xNu1Q^a 4;9EUlv&wvV ;-'<<6fm<5|[jѣC Э6TkSB!;}[0/eFjBa@]P~Vl87T!'̯مR)8t'@%|%|FRzaůqN +ћT_ۈĸymG6GrIJwpfΊ{Pv'n0c´^Gy[h/Ůty& Z%DЪ"E>NlmÈ=)9v{Lyc6n;x MuFVuj$;0g%K=m*< fF*Vv@KY*Q]=1ws7Q'We`w<mn@_:p5+Qa CXʎ-n*aCG:!nM . /wkjgdG 閾Nqm \,^9 1[NY|.7/v-cNT1i;kcC47C{y6^g6mj{1ژ8}G @9\=1waj5 e:{d&; *v? 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"1 N2& X@ njQ;QVZT0"䙍Pv"{Rơ$79cX׊Ϭ{%wb+ N)W YhsH1b{a%u3刎[#c1n]K{N.jWV{J\se< ]Wn(mvfh!HPc 7M7Rk9Z20Rm_vUPF\=\A1"03ˆ UaǗ na0xM\\MLA,MR`ZtlI]3 ^ja>Ȃn-1ˀkPTp}@eE)bCAU~ + k۞@rxpOEN+S,oPŬu]w 1x6=z)6-^5BkT4"чOW1LsEޱXb)xyQf2*GVs>ċ*+~8W.!}1ImX^`0r)݋񘊁^P0<S˲"^z*8V 8zͯE#k˛@3ضgSKj,*Rh% CZsF}ci]+ ^jaȂn-1BqUI5X2 бU[R^*&VexXY ]Jx+H*XCHVWg0v]^ЬE&R:J6 bD)g &Tڟt@Zzoil]j!uG ZEGdt@ U?^{o ukd)6nku/N*UJ21%K -߱jt}c^ SMEgd2@`\YS&%2VKZP ѦKݺ#q1)>á؀ꊎ*1u'y.xKuU.hn`.@e " Z=@^ĝஊ╎u6\ZS XI|_+*NF>PTqu0CrlxSh%4غ -(~ i{ -1# >r`}6z_4ҭ^Jt#Z`t" <-f j]\6նap~'RMNلRk-hV#+2!hkSWAU8N-uJT{K$rI@]LUjO{jS4Ackͣ|ˢ-.)Z1$bqs?|<_Q ^`1؊XjQV{X_1arPôR~iJLUl6'Il30VTuF\ >nA X߹qMn \#VWÚN5HvHt (X0x\^ JUj؈ygF&p.В]YE]M!i:>e44ߒZS7&[PP i3Odʇ aq&V΁庀f"4f A]ٸMn+ěUca&D>;IZd {1`HRc &mX|%8ŏɦt$ƼLŽ,FXϗU"k[S7ϒOA323՘.WV36}GHnc,to-.rL~6wGZVḢKZ좰mˤK{!pyGI`9 q"Oe~n͖fo"CI2ӚFuO[K.`?iXmPb wiT8^*xSꌴTC@r@]: LZbvظK3Rw4xOBd{xJzXp\8q qi1pb\ Z qj\'V5lMG3'Xտct=(YW-sp|"f'"]k׹gyivSj`]ڸb]h.4,5ݭpo?.cêa3b|!/9f{EXɑ0brw>nvPy#+ON\$h5;*جU\? 2lVfhu>v;<:А@=Z8gWlcI-ƺz*yI-=%4#ofZL~DE`apnj^'XKL6P5yJ_3n#PN8$U>wi+p(žWt͉`c졤b_Oѷ^<+H.ٝ5*o5t0LcIC-'ibqZTOxleHx ֠ "rto `y0g[_"M>stream endstream endobj 1321 0 obj <>stream endstream endobj 1227 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\034\201\016\r\016\215\026\021\r\215\001\004 \017\021\020\016\f\215\001\004\ \b)-10(\026)11(\025\024\001: \021\t\016\025\b)-9.9(\026)10.9(\025\024\001, \017)10(\025\t\025\b)-10(\026)11(\025\024\001. \037)40.9(\001\017)10.1(\025\207 \r\001\201\021\001\215\026 )]TJ 0 -1 TD [(\235\016\213\025\222\001\b\215\016\016? \(\024\016\026)11(\001\001\215\001\t\021\213\022\021\022\b\021\b)-10(\026)11(\016\024\001\026\021\f\016\b\017\021\207 \025\235\213\025\201 \t\021\026\ )11(\016\201\001\026)-20(\200\201\220\))]TJ 41.159 1 Td [(Pr)31(e)11(v)12(entiv)12.1(e intestinal stoma: ileostom)21(y)31(, colostom)21(y)52(. )]TJ -4.661 -1 Td [(W)30(hich\022option\022is\022safer? \(meta-analy)10(sis and s)10(y)10(stematic r)31(e)11(vie)11(w\))]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0.063 Tw 10 0 0 10 42.5197 724.8299 Tm (\212\236: 0,67\2264,15; )Tj /T1_2 1 Tf 0 Tw (\033)Tj /T1_1 1 Tf 0.063 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,27\) \(\217\017\f.)Tj /Span<>> BDC ( )Tj EMC (14\202\); \(\210\221)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (1,20; 95% )Tj 0 Tw 0 -1.218 TD (\212\236: 0,57\2262,52; )Tj /T1_2 1 Tf (\033)Tj /T1_1 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,64\) \(\217\017\f.)Tj /Span<>> BDC ( )Tj EMC (14\207\), \f\024\024\021\r\036\021\f\021\r\036\027\027\024.)Tj /T1_2 1 Tf 0 -2.436 TD (\r\022\001\016\005\020\037\030 \020\016\f\033\034\002\034\b\022\006\034\024\ \035\003)Tj /T1_1 1 Tf 0.455 Tw 0 -1.218 TD (\025\026\022 \r)Tj /Span<>> BDC ( )Tj EMC (\030\026\027\007\024\n\017\017\030\024\r\026\027\027\t\b, \021\026\022 \ \017)Tj /Span<>> BDC ( )Tj EMC (\r \f\030\026\r\027\017\021\036\035\034)Tj 0 Tw (-)Tj 0.344 Tw T* (\027\t\b \027\036\030\026\027\007\024\n\017\017\030\024\r\026\027\027\t\ \b \017\f\f\035\036\007\024\r\026\027\017\016\b \004\026\f\021\024\021\026\ )Tj -0.019 Tw 23.244 6.089 Td (\r\024\027\017\022\027\024\r\036\027\017\016 \022\017\001\036\004\027\024\ \005 \027\036\023\030\024\b\024\007\017\n\024\f\021\017 \n\036\032\007\031\ \023\026)Tj 0 Tw (-)Tj T* (\006\017\036\027\021\026\n\017 \f)Tj /Span<>> BDC ( )Tj EMC (\022\024\035\024\f\021\024\n\024\005 \017)Tj /Span<>> BDC ( )Tj EMC (\017\035\036\024\f\021\024\n\024\005 \027\036 \030\026\035\017\004\026\035\ \026\f\034 )Tj 0.063 Tw T* (\(\210\221)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,89; 95% \212\236:)Tj /Span<>> BDC ( )Tj EMC (0,32\2262,46; )Tj /T1_2 1 Tf 0 Tw (\033)Tj /T1_1 1 Tf 0.063 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,83\) \(\217\017\f.)Tj /Span<>> BDC ( )Tj EMC (15\202\); )Tj 0.075 Tw T* (\(\210\221)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,62; 95% \212\236: 0,33\2261,16; )Tj /T1_2 1 Tf 0 Tw (\033)Tj /T1_1 1 Tf 0.075 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,14\) \(\217\017\f.)Tj /Span<>> BDC ( )Tj EMC (15\207\), )Tj 0 Tw T* (\f\024\024\021\r\036\021\f\021\r\036\027\027\024.)Tj ET q /GS0 gs 453.543294 0 0 130.7836515 42.5196838 515.8282259 cm /Im0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 9 0 0 9 42.5197 504.9642 Tm (\022\t\217\210\b\002\220 12\032.)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf [( \t\037\033\037\024\035\034\006\037\027\003\020\037\030 \013\033\032\201\ \037. \213\016\031\023\027\003\035\037\035\032 \033\037\020\b\034\006\022\ \031\022\033\034\036\037\020)0.5(\020\032\002 \022\024\024\027\016\b\034\036\037\020\022\004)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0 -1.2 TD [(F)-16(igure 1)94.1(2A)-15(.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf [( P)18(arastomal her)-13.9(nia. R)21.1(esults of)]TJ /Span<>> BDC ( )Tj EMC [(randomized tr)-36.8(ials)]TJ ET q 42.52 284.976 453.543 198.684 re W n q /GS0 gs 453.543294 0 0 198.6951574 42.5196838 284.965121 cm /Im1 Do Q Q BT 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 9 0 0 9 42.5197 274.1764 Tm (\022\t\217\210\b\002\220 12\223.)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf [( \t\037\033\037\024\035\034\006\037\027\003\020\037\030 \013\033\032\201\ \037. \213\016\031\023\027\003\035\037\035\032 \024\033\037\036\020\022\035\ \016\027\003\020\032\002 \020)0.5(\016\033\037\020\b\034\006\022\031\022\033\034\036\037\020\020\032\002 \022\ \024\024\027\016\b\034\036\037\020\022\004)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf T* [(F)-16(igure 1)94.1(2B.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf [( P)18(arastomal her)-13.9(nia. R)21.1(esults of)]TJ /Span<>> BDC ( )Tj EMC [(com)16.1(parativ)13(e non-randomized tr)-36.8(ials)]TJ ET q /GS0 gs 453.543294 0 0 141.1023581 42.5196838 111.7700937 cm /Im2 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0.02 Tw 9 0 0 9 42.5197 100.9701 Tm (\022\t\217\210\b\002\220 13.)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf ( \t\034\024\027\016\034\f\016\033\037\007\022\034\020\020\037\030 \013\033\ \032\201\037 \036)Tj /Span<>> BDC ( )Tj EMC (\034\025\027\037\024\035\022 \033\037\020\016\016 \036\032\036\016\b\016\ \020\020\034\004 \024\035\034\006\032. \213\016\031\023\027\003\035\037\035\ \032 \024\033\037\036\020\022\035\016\027\003\020\032\002 \020\016\033\037\ \020\b\034\006\022\031\022)Tj 0 Tw (-)Tj T* (\033\034\036\037\020\020\032\002 \022\024\024\027\016\b\034\036\037\020\022\ \004)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf T* [(F)-16(igure 1)93.1(3.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf [( P)15(ostoperativ)13.1(e her)-14(nia in the)]TJ /Span<>> BDC ( )Tj EMC (area of)Tj /Span<>> BDC ( )Tj EMC (a)Tj /Span<>> BDC ( )Tj EMC [(p)46.2(reviously remov)13.1(ed stoma. The)]TJ /Span<>> BDC ( )Tj EMC (results of)Tj /Span<>> BDC ( )Tj EMC [(com)16(parativ)13(e randomized tr)-37(ials)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\007\003\032)50(\n\n\217\n)-21(\035\030\002)]TJ 53.418 0 Td [(MET)30(A)-41(-)-41.9(ANAL)30(Y)30(SIS)]TJ /T1_4 1 Tf 25 0 0 25 504.6646 56.0378 Tm (161)Tj ET endstream endobj 1228 0 obj <>stream Adobed     '$''''$25552;;;;;;;;;;   %%#(((((#,0000,7;;;7;;;;;;;;;;   %%#(((((#,0000,7;;;7;;;;;;;;;;   %%#(((((#,0000,7;;;7;;;;;;;;;;<""  ^C !"#$%&'()*123456789:ABCDEFGHIJQRSTUVWXYZabcdefghijqrstuvwxyz !1AQaq"2UB#br $%&'()*3456789:CDEFGHIJRSTVWXYZcdefghijstuvwxyz?"No_ԦӧEKB5j>JkiKw#Q"ؼ#ֻ"kR{ d#huCibH`:kZ<T'ƾlvZC 0E+JQ1j.ӥF"|Jj()RmM+/m|)3el}@Szp:\l!s_fbvkCRHÊ;gS΀{hlN4!~j22\*+'V5}E9" u0jm _LרU(uU,lҀb5]S;eCjh`cL4+cc0.xg/h uo3/"#g 4mxiuOUuTczckU6o\@[;ѭM{c8KGm_O|=nܐdEQtiTm Eb᧸ZKKrNqazxJBֆ~"nnmOg`vn`n)u]mZѐEIJJJKִI$z85+k$ Fs èGfnkKU 6uu%Nim tΫ!ǽx /m E<5VұC3UeB'܁Ӷ[NҡAejOS!7OBα}JvW۵YQf{X6E϶lCؖhdA.%q>lm^ʌߣEƲ\e8@p،>.u[_UA`(GR;F(]u6Tֹ@+GV} 4St9A m.ی[TTc!p 2zRm-ӣX5%xDa|gqwS/i:2Jƶ hѬ_Mͭ0ּ9>h]nsNjlb C=u7 = );i1K-{n tEʑ}y=N?k]T !dX Pn]L }umgHUny@r5Xӫ=V*j"Z\ #P*zUa!pЫX͗QWb_L ǂKNSk-k<8<{ ʹWKeר[*4iEL3h}SL:D^AtU[2' ws1;ꉮl^' u̬7V)b0im l݃ڔjףTH}Jr;I]N;i8Tc0-#~M8)m7:،3x]mmL#T-8!"Lc85 N@4*(,S L=A o]/šԜ[N!M257A"føCnXԨ^ #UYJ77M6po_xql^x *vN!o 6qi=lKH ٝD\KqIp2j0LT/BZ'~.hm۸vFd9;iIq/s?}8-\j+7v73q(\kq+_[11#>%ibHXOfݱ8LU:wq) *6@ؚha욕1kb@AxĻzΖh*+GQU18OYuzc6ip)hESs d#""}L?kTƇu0ֵr|"+8lv#*CLWXra[davg*9|3pknx6K6*v VRVw4`@Z͢ԱV1ML^W;CyF:ۦ7cz;[qZaC"as0tu1):WeL@Js[T ySw'ꂛ,q~k,fX=c}JdZ`N[\5~RFڝmF|w,~UO9_l~xTAu>8;!A7hK[o@7Ay0 -.?_ib*bq߫P9@U_[zYV.ImzO͍Zf&+e\UIѠwFv@Z$__SOh6k47]cDEe7lb݅$\1ݱ例g#\qi~;_¢}Kuퟂaí6t"BOC+x>&[Tn] /EwS8ڧTSĚ,c]RcqjVҗQmq>X^%P"=S*YjƑg4g>7v눖5`ϠV.Ji /CLؒCw9 .z麱ؘ]C ^i^zヌF` ͣnPmGŇD@"4AE!l{icF!)%1[d69|>w̝8+Ol71xUpam:. 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95% \212\236: 0,85\2263,2; )Tj /T1_1 1 Tf 0 Tc 0 Tw (\033)Tj /T1_0 1 Tf 0.014 Tc 0.043 Tw /Span<>> BDC 13.819 0 Td ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,14\) \(\217\017\f.)Tj /Span<>> BDC ( )Tj EMC [(11\202\);)14( )]TJ 0.004 Tw -13.819 -1.218 Td (\(\210\221)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,61; 95% \212\236: 0,23\2261,67; )Tj /T1_1 1 Tf 0 Tc 0 Tw (\033)Tj /T1_0 1 Tf 0.014 Tc 0.004 Tw /Span<>> BDC 14.1 0 Td ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,34\) \(\217\017\f.)Tj /Span<>> BDC ( )Tj EMC [(11\207\),)14( )]TJ -0.014 Tw -14.1 -1.218 Td (\f\024\024\021\r\036\021\f\021\r\036\027\027\024.)Tj /T1_1 1 Tf 0 Tc 0 Tw 0 -2.436 TD (\t\037\033\037\024\035\034\006\037\027\003\020\037\030 \013\033\032\201\037\ )Tj /T1_0 1 Tf -0.046 Tw 0 -1.218 TD (\215\030\017 \026\027\026\035\017\036 \030\026\027\007\024\n\017\017\030\ \024\r\026\027\027\t\b \017\f\f\035\036\007\024\r\026\027\017\005 \031\f\ \021\026)Tj 0 Tw (-)Tj 0.054 Tw 0 -1.218 TD (\027\024\r\035\036\027\024, \004\021\024 \023\026\030\026\f\021\024\n\026\ \035\034\027\026\016 \020\030\t\032\026 \024\002\030\026\024\r\t\r\026\035\ \026\f\034 )Tj 0.118 Tw 0 -1.218 TD (\031)Tj /Span<>> BDC ( )Tj EMC (2 \017)Tj /Span<>> BDC ( )Tj EMC (161 \023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\022\024\035\024\f\021\024\n\024\005 \017)Tj /Span<>> BDC ( )Tj EMC (\031 3 \017)Tj /Span<>> BDC ( )Tj EMC (157)Tj /Span<>> BDC ( )Tj EMC (\227 )Tj 0.447 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\017\035\036\024\f\021\024\n\024\005: \(\210\221)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,65; 95% \212\236: 0,08\2265,26; )Tj /T1_1 1 Tf 0 Tw T* (\033)Tj /T1_0 1 Tf 0.066 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC 1.575 0 Td (0,69\) \(\217\017\f.)Tj /Span<>> BDC ( )Tj EMC 4.784 0 Td [(12\202\), \024\007\027\026\022\024 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 6.409 0 Td [(\f\030\026\r\027\017\021\036\035\034\027\t\b )0.5(\027\036\030\026\027)]TJ 0 Tw (-)Tj 0.137 Tw -12.768 -1.218 Td (\007\024\n\017\017\030\024\r\026\027\027\t\b \030\026\002\024\021\026\b\ \007\026\027\027\024\036 \024\f\035\024\032\027\036\027\017\036 \024\002\ \027\026)Tj 0 Tw (-)Tj 0.074 Tw T* (\030\031\032\036\027\024 \031)Tj /Span<>> BDC ( )Tj EMC (89 \017)Tj /Span<>> BDC ( )Tj EMC (1102 \023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\022\024\035\024\f\021\024\n\024\005 \017)Tj /Span<>> BDC ( )Tj EMC (\031 47 )Tj 0.002 Tw 0 -1.218 TD (\017)Tj /Span<>> BDC ( )Tj EMC 1.179 0 Td [(1089 )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC 2.906 0 Td [(\017\035\036\024\f\021\024\n\024\005 )0.6(\(\210\221)]TJ /Span<>> BDC ( )Tj EMC 7.077 0 Td (=)Tj /Span<>> BDC ( )Tj EMC 0.734 0 Td [(1,31; )0.5(95% )0.5(\212\236: )0.6(0,78\2262,21; )]TJ /T1_1 1 Tf 0 Tw -11.897 -1.218 Td (p)Tj /T1_0 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,31\) \(\217\017\f.)Tj /Span<>> BDC ( )Tj EMC (12\207\), \f\024\024\021\r\036\021\f\021\r\036\027\027\024.)Tj /T1_2 1 Tf 0.274 Tw 0 -2.436 TD (\017\217\f\002\202\b\r\b\t\235, \217\235\213\004\b\b\013\r \217)Tj /Span<>> BDC ( )Tj EMC (\006\r\220\002\b\217\003\006\210\220\003\t\b\002-\002\217)Tj 0 Tw (-)Tj 0 -1.218 TD (\217\003\004\b\002\t\003\r\f\001\b\002\005 \002\212\r\006\004\204\t\r\005\ )Tj /T1_0 1 Tf T* (\215\030\017 \017\031\004\036\027\017\017 \r\f\036\b \017\f\f\035\036\007\ \024\r\026\027\017\005, \r\022\035\033\004\036\027\027\t\b \r)Tj /Span<>> BDC ( )Tj EMC (\007\026\027)Tj (-)Tj T* (\027\t\005 \n\036\021\026\026\027\026\035\017, \r\f\021\030\036\004\026\ \035\017\f\034 \021\026\022\017\036 \024\f\035\024\032\027\036\027\017\016\ , \022\026\022:)Tj 0.061 Tw T* (\226)Tj /Span<>> BDC [( )-206( )]TJ EMC 1.056 0 Td (\030\026\027\036\r\026\016 \017\027\235\036\022\006\017\016 \017)Tj /Span<>> BDC ( )Tj EMC (\020\036\n\026\021\024\n\026 \023\036\030\036\007\027\036\005 \002\030\033\ \001\027\024\005 )Tj 0 Tw T* (\f\021\036\027\022\017;)Tj 0.248 Tw 22.188 24.356 Td (\226)Tj /Span<>> BDC [( )-19( )]TJ EMC 1.056 0 Td (\022\017\001\036\004\027\026\016 \027\036\023\030\024\b\024\007\017\n\024\ \f\021\034 \017)Tj /Span<>> BDC ( )Tj EMC (\023\024\f\035\036\024\023\036\030\026\006\017\024\027\027\026\016 )Tj 0 Tw T* (\020\030\t\032\026 \r)Tj /Span<>> BDC ( )Tj EMC (\024\002\035\026\f\021\017 \030\026\027\036\036 \r\t\r\036\007\036\027\027\ \024\005 \f\021\024\n\t.)Tj /T1_1 1 Tf -0.002 Tw -1.056 -2.436 Td (\t\034\024\027\016\034\f\016\033\037\007\022\034\020\020\037\030 \013\033\ \032\201\037 \036)Tj /Span<>> BDC ( )Tj EMC (\034\025\027\037\024\035\022 \033\037\020\016\016 \036\032\036\016\b\016\ \020)Tj 0 Tw (-)Tj T* (\020\034\004 \024\035\034\006\032)Tj /T1_0 1 Tf 0.02 Tw T* (\212\026\027\027\t\036 \024)Tj /Span<>> BDC ( )Tj EMC (\r\024\027\017\022\027\024\r\036\027\017\017 \023\024\f\035\036\024\023\ \036\030\026\006\017\024\027\027\024\005 \020\030\t\032\017 )Tj 0.091 Tw 0 -1.218 TD (\023\024\f\035\036 \035\017\022\r\017\007\026\006\017\017 \f\021\024\n\t\ \002\t\035\017 \023\030\036\007\f\021\026\r\035\036\027\t \021\024\035\034\ \022\024 )Tj 0.193 Tw 0 -1.218 TD (\r)Tj /Span<>> BDC ( )Tj EMC 0.9 0 Td [(\f\030\026\r\027\017\021\036\035\034\027\t\b )0.5(\027\036\030\026\027\007\024\n\017\017\030\024\r\026\027\027\t\b )0.5(\017\f\f\035\036\007\024\r\026)]TJ 0 Tw (-)Tj 0.206 Tw -0.9 -1.218 Td [(\027\017\016\b, )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 3.481 0 Td [(\021\024 )0.5(\r\030\036\n\016 )0.5(\022\026\022 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 6.979 0 Td [(\030\026\027\007\024\n\017\017\030\024\r\026\027\027\t\b )0.6(\017\f\f\035\036)]TJ 0 Tw (-)Tj 0.086 Tw -10.46 -1.218 Td (\007\024\r\026\027\017\016\b \007\026\027\027\024\036 \024\f\035\024\032\ \027\036\027\017\036 \027\036 \017\031\004\026\035\024\f\034. \232\026\f\ \021\024\021\026 )Tj 0.251 Tw T* (\r\024\027\017\022\027\024\r\036\027\017\016 \023\024\f\035\036\024\023\ \036\030\026\006\017\024\027\027\024\005 \020\030\t\032\017 \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017)Tj 0 Tw (-)Tj 0.174 Tw T* (\036\027\021\024\r \023\024\f\035\036 \035\017\022\r\017\007\026\006\017\ \017 \022\024\035\024\f\021\024\n\t \017\035\017 \017\035\036\024\f\021\024\ \n\t )Tj -0.011 Tw 0 -1.218 TD (\027\036)Tj /Span<>> BDC ( )Tj EMC 1.199 0 Td [(\030\026\035\017\004\026\035\026\f\034 )0.6(\(\210\221)]TJ /Span<>> BDC ( )Tj EMC 7.318 0 Td (=)Tj /Span<>> BDC ( )Tj EMC 0.721 0 Td [(1,09; )0.6(95% )0.5(\212\236: )0.6(0,3\2264,02; )]TJ /T1_1 1 Tf 0 Tw 9.896 0 Td (\033)Tj /T1_0 1 Tf -0.011 Tw /Span<>> BDC ( )Tj EMC 0.699 0 Td (=)Tj /Span<>> BDC ( )Tj EMC 0.721 0 Td (0,9\) )Tj 0 Tw -20.555 -1.218 Td (\(\217\017\f.)Tj /Span<>> BDC ( )Tj EMC (13\).)Tj /T1_1 1 Tf 0.256 Tw 0 -2.436 TD (\213\037\020\016\036\037\030 \022\020\017\016\021\007\022\030 \022)Tj /Span<>> BDC ( )Tj EMC (\013\016\006\037\035\034\006\037 \f\016\033\016\b\020\016\004 \025\033\026\ \001\020\034\004 )Tj 0 Tw 0 -1.218 TD (\024\035\016\020\021\022)Tj /T1_0 1 Tf 0.238 Tw T* (\215\030\017 \026\027\026\035\017\036 \030\026\027\007\024\n\017\017\030\ \024\r\026\027\027\t\b \017)Tj /Span<>> BDC ( )Tj EMC (\f\030\026\r\027\017\021\036\035\034\027\t\b )Tj 0.089 Tw T* [(\027\036\030\026\027\007\024\n\017\017\030\024\r\026\027\027\t\b )0.6(\017\f\f\035\036\007\024\r\026\027\017\005 )0.6(\004\026\f\021\024\021\026 )0.5(\030\026\r\017)]TJ 0 Tw (-)Tj -0.052 Tw T* (\021\017\016 \007\026\027\027\024\020\024 \024\f\035\024\032\027\036\027\ \017\016 \002\t\035\026 \f\024\023\024\f\021\026\r\017\n\026 \n\036\032\007\ \031 \023\026)Tj 0 Tw (-)Tj -0.044 Tw T* (\006\017\036\027\021\026\n\017 \f)Tj /Span<>> BDC ( )Tj EMC (\022\024\035\024\f\021\024\n\024\005 \017)Tj /Span<>> BDC ( )Tj EMC (\017\035\036\024\f\021\024\n\024\005 \(\210\221)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (1,67; 95% )Tj ET q /GS0 gs 453.543294 0 0 131.0236183 70.8661499 328.1464257 cm /Im0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0 Tw 9 0 0 9 70.8661 317.3464 Tm (\022\t\217\210\b\002\220 11\032.)Tj 0 0 0 1 k /GS1 gs /T1_1 1 Tf [( \217\016\024\034\024\035\034\030\035\016\027\003\020\034\024\035\003 \037\ \020\037\024\035\034\006\034\031\037. \213\016\031\023\027\003\035\037\035\ \032 \033\037\020\b\034\006)0.5(\022\031\022\033\034\036\037\020\020\032\002 \022\024\024\027\016\b\034\036\ \037\020\022\004)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0 -1.2 TD [(F)-16(igure 1)158.1(1A)-15(.)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf [( Anastomosis leak)11.1(ag)12(e. R)21.1(esults of)]TJ /Span<>> BDC ( )Tj EMC [(randomized tr)-36.8(ials)]TJ ET q 70.866 100.97 453.543 195.072 re W n q /GS0 gs 453.543294 0 0 195.0956122 70.8661194 100.9468682 cm /Im1 Do Q Q BT 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 9 0 0 9 70.8661 90.1701 Tm (\022\t\217\210\b\002\220 11\223.)Tj 0 0 0 1 k /GS1 gs /T1_1 1 Tf [( \217\016\024\034\024\035\034\030\035\016\027\003\020\034\024\035\003 \037\ \020\037\024\035\034\006\034\031\037. \213\016\031\023\027\003\035\037\035\ \032 \024\033\037\036\020\022\035\016)0.5(\027\003\020\032\002 \020\016\033\037\020\b\034\006\022\031\022\033\034\036\ \037\020\020\032\002 \022\024\024\027\016\b\034\036\037\020\022\004)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf T* [(F)-16(igure 1)158.1(1B.)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf [( Anastomosis leak)11.1(ag)12(e. 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\(\024\016\026)11(\001\001\215\001\t\021\213\022\021\022\b\021\b)-10(\026)11(\016\024\001\026\021\f\016\b\017\021\207 \025\235\213\025\201 \t\021\026\ )11(\016\201\001\026)-20(\200\201\220\))]TJ 41.159 1 Td [(Pr)31(e)11(v)12(entiv)12.1(e intestinal stoma: ileostom)21(y)31(, colostom)21(y)52(. )]TJ -4.661 -1 Td [(W)30(hich\022option\022is\022safer? \(meta-analy)10(sis and s)10(y)10(stematic r)31(e)11(vie)11(w\))]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0.032 Tw 10 0 0 10 42.5197 724.8299 Tm (\r\024\027\017\022\026\035\026 \r)Tj /Span<>> BDC ( )Tj EMC (3 \030\026\026 \004\026\013\036, \004\036\n \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\017\035\036\024\f\021\024)Tj 0 Tw (-)Tj -0.057 Tw 0 -1.218 TD (\n\024\005 \(\210\221)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (3,86; 95% \212\236: 1,27\22611,72; )Tj /T1_2 1 Tf 0 Tw (\033)Tj /T1_1 1 Tf -0.057 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,02\) \(\217\017\f.)Tj /Span<>> BDC ( )Tj EMC (9\). )Tj 0.018 Tw T* (\236\027\235\024\030\n\026\006\017\016 \024)Tj /Span<>> BDC ( )Tj EMC (\r\024\027\017\022\027\024\r\036\027\017\017 \f\021\030\017\022\021\031\ \030\t \r)Tj /Span<>> BDC ( )Tj EMC (\030\026\027\007\024\n\017)Tj 0 Tw (-)Tj T* (\017\030\024\r\026\027\027\t\b \017\f\f\035\036\007\024\r\026\027\017\016\ \b \027\036 \235\017\020\031\030\017\030\024\r\026\035\026.)Tj /T1_2 1 Tf 0 -2.436 TD (\t\033\034\027\037\f\024 \024\035\034\006\032)Tj /T1_1 1 Tf 0.115 Tw 0 -1.218 TD (\200 \030\026\027\007\024\n\017\017\030\024\r\026\027\027\t\b \017)Tj /Span<>> BDC ( )Tj EMC (\f\030\026\r\027\017\021\036\035\034\027\t\b \027\036\030\026\027\007\024\ \n\017)Tj 0 Tw (-)Tj 0.231 Tw 0 -1.218 TD (\017\030\024\r\026\027\027\t\b \017\f\f\035\036\007\024\r\026\027\017\016\ \b \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\235\024\030\n\017\030\024\r\026\027\017\017 \022\024)Tj 0 Tw (-)Tj 0.198 Tw T* (\035\024\f\021\024\n\t \023\030\024\035\026\023\f \r\024\027\017\022\026\ \036\021 \f\021\026\021\017\f\021\017\004\036\f\022\017 \027\026\004\017\ \n\024 )Tj 0.035 Tw T* (\004\026\013\036, \004\036\n \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\235\024\030\n\017\030\024\r\026\027\017\017 \017\035\036\024\f\021\024\n\ \t \(\210\221)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (8,87; )Tj 0.581 Tw 23.244 10.96 Td (95% \212\236: 2,53\22631,12; )Tj /T1_2 1 Tf 0 Tw (\033)Tj /T1_1 1 Tf 0.581 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,0007\) \(\217\017\f.)Tj /Span<>> BDC ( )Tj EMC (10\202\); )Tj 0.025 Tw T* (\(\210\221)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (2,91; 95% \212\236: 1,49\2265,72; )Tj /T1_2 1 Tf 0 Tw (\033)Tj /T1_1 1 Tf 0.025 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,002\) \(\217\017\f.)Tj /Span<>> BDC ( )Tj EMC (10\207\), )Tj 0 Tw T* (\f\024\024\021\r\036\021\f\021\r\036\027\027\024.)Tj /T1_2 1 Tf 0 -2.436 TD (\217\016\024\034\024\035\034\030\035\016\027\003\020\034\024\035\003 \021\ \034\027\034\033\016\021\035\037\027\003\020\034\013\034 \037\020\037\024\ \035\034\006\034\031\037)Tj /T1_1 1 Tf 0.014 Tc 0.147 Tw 0 -1.218 TD (\025\026\022 \r)Tj /Span<>> BDC ( )Tj EMC (\030\026\027\007\024\n\017\017\030\024\r\026\027\027\t\b, \021\026\022 \ \017)Tj /Span<>> BDC ( )Tj EMC [(\r \f\030\026\r\027\017\021\036\035\034\027\t\b)14( )]TJ 1.02 Tw 0 -1.218 TD (\027\036\030\026\027\007\024\n\017\017\030\024\r\026\027\027\t\b \017\f\ \f\035\036\007\024\r\026\027\017\016\b \r\t\016\r\035\036)Tj 0 Tc 0 Tw (-)Tj 0.014 Tc 0.342 Tw 0 -1.218 TD [(\027\024, \004\021\024 \027\026\035\017\004\017\036 \023\030\036\r\036\027\ \021\017\r\027\024\005 \f\021\024\n\t \027\036 \r\035\017\016\036\021)14.1( )]TJ 0.304 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC (\004\026\f\021\024\021\031 \030\026\r\017\021\017\016 \027\036\f\024\f\021\ \024\016\021\036\035\034\027\024\f\021\017 \022\024\035\024\030\036\022)Tj 0 Tc 0 Tw (-)Tj 0.014 Tc 0.163 Tw T* (\021\026\035\034\027\024\020\024 \026\027\026\f\021\024\n\024\026 \017)Tj /Span<>> BDC ( )Tj EMC [(\027\036 \026\r\017\f\017\021 \024\021 \r\017\007\026 \f\021\024\n\t:)14( )]TJ ET q 42.52 471.591 453.543 120.464 re W n q /GS0 gs 453.543294 0 0 120.4649384 42.5196838 471.5906036 cm /Im0 Do Q Q BT 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0 Tc 0 Tw 9 0 0 9 42.5197 460.7758 Tm (\022\t\217\210\b\002\220 9.)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf [( \207\035\033\022\021\035\023\033\037 \024\035\034\006\032. \213\016\031\ \023\027\003\035\037\035\032 \024\033\037\036\020\022\035\016\027\003\020\ \032\002 \020\016\033\037\020\b\034)0.5(\006\022\031\022\033\034\036\037\020\020\032\002 \022\024\024\027\016\b\034\ \036\037\020\022\004)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0 -1.2 TD [(F)-16(igure 9)32.1(.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf [( S)28(toma str)-36.9(icture. R)21.1(esults of)]TJ /Span<>> BDC ( )Tj EMC [(com)16.1(parativ)13(e non-randomized tr)-36.8(ials)]TJ ET q /GS0 gs 453.543294 0 0 130.7836515 42.5196838 308.6882418 cm /Im1 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 9 0 0 9 42.5197 297.8242 Tm (\022\t\217\210\b\002\220 10\032.)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf [( \t\033\034\027\037\f\024 \024\035\034\006\032. \213\016\031\023\027\003\ \035\037\035\032 \033\037\020\b\034\006\022\031\022\033\034\036\037\020\020\ \032\002 \022\024\024\027)0.5(\016\b\034\036\037\020\022\004)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf T* [(F)-16(igure 1)70.1(0A)-15(.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf [( S)28(toma p)46(rolapse. R)21.1(esults of)]TJ /Span<>> BDC ( )Tj EMC [(randomized tr)-36.7(ials)]TJ ET q /GS0 gs 453.543294 0 0 175.4180666 42.5196838 101.102197 cm /Im2 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 9 0 0 9 42.5197 90.1701 Tm (\022\t\217\210\b\002\220 10\223.)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf [( \t\033\034\027\037\f\024 \024\035\034\006\032. \213\016\031\023\027\003\ \035\037\035\032 \024\033\037\036\020\022\035\016\027\003\020\032\002 \020\ \016\033\037\020\b\034\006\022\031\022\033\034\036)0.5(\037\020\020\032\002 \022\024\024\027\016\b\034\036\037\020\022\004)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf T* [(F)-16(igure 1)70.1(0B.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf [( S)28(toma p)46(rolapse. 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H LU iNOoT]k$w K9oLtQm2m$Ĵ!+87!sz=j^k\^FL^d[ml{Bjթv.:!Ta۹JZmeG4I|VĐkU}RQ%{ ~ХS Yh0`7z,zWxvr .ܘ. jzEʏ82AEԩٴuW\P.;9UvmGcmV<8h&@Z`q pުK\6Pp/tE{QL7gbKXI$ F }K=׹KdA|.k3[:=I^f/+ҧn M^9G..uFJ3i |oc$.tTPٸTvk2xNvJ઴m=GTi`qlP @Z@^@4+D/Td3e٘LE]0Lb|+n ?^U?=ulcv+/4U4f@6 /oZ|C&ۼaisxjklV$l}J-BQ&8{輻kmNUp3C+ﾱ-ʿ?37ݿ4"Z/g=ԅgn >7K9 K;n[5mc0EsQժ1U~pkI,"""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""+/gi♆kL8w@cK1|83js SHqbz n 41mė Zǰp :;D(Ti%714)l4oƙr ϩ^k2fWڕ 6@^Q886@1rjZ ViVusHq طcp)58-"Ä3SOݤOݨʃ2@.$6Pja 0u bKLQ~Z.GՆr;H6+8f" y0Ƹ6 hn~#[ PүMԪ76=E 5; OVshbZ{{َfjGAr;7Zr@Z`q5(/uu@Z:K*j1[lK/[]Sgb)]G sLQ£r&l*RkvI{' fu@^[`."C^G1EQs'సVcDccqGx{gmZu)PmRk"")O:(oB"bv&;V,6-@D¤5g9\iI=^imJ8}~*j>-ť|VjQ6v-h>98 X5hT&<;a5Z$hbi:ӫ@s˜yCYT2tzqxGmo{ 5MC5VicjkpxZ <̏Z"pzn+zgqlp_5vv2N {\ֹr@V4O$ X&zeJ{;FԧX+k NCfָmPe -c@$q= JU Z/eR-M!xW QQ!5fZjc}pt3݀vn'j Nh $;"mUx17CJ&FRmc9⛪m;2xq6+8XAswi<2#v^3}j50N 7k Ge*G ;x9"y+S4-'::>qTp<[ڎnp0S5"C4$Qy rr$פkIh{h E=ZF0C0bZeCʭ'(1Xb"QyL68z/%ۍ. vlMLMy uC 2=kE*JJLQ~zV;|Q0Q)'; /+_SeZ_M|G9uðX0u5Ť$6xAr( Ôi 7Y]vq ͦ d\'<sR49 躉Ƶi | ƌ>8HѬf\渷q9tG@OC0t-Ð>FAtEDDDDDժ" @E33aDEQ.{.q$ܒ endstream endobj 1349 0 obj <>stream endstream endobj 1348 0 obj <>stream endstream endobj 1347 0 obj <>stream endstream endobj 1334 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 0 0 0 1 k /GS1 gs /T1_0 1 Tf 10 0 0 10 70.8661 724.8299 Tm (\240\025\016\031\036\034\201\022\036\037\020\022\016)Tj /T1_1 1 Tf 0.519 Tw 0 -1.218 TD [(\200 )0.5(\030\026\027\007\024\n\017\017\030\024\r\026\027\027\t\b )0.5(\017\f\f\035\036\007\024\r\026\027\017\016\b )0.6(\036\007\017\027\017\004\027\t\036 )]TJ 0.498 Tw T* [(\f\035\031\004\026\017 \007\026\027\027\024\020\024 \024\f\035\024\032\027\ \036\027\017\016 )0.5(\r\f\021\030\036\004\026\035\017\f\034 \017\f\022\035\033)]TJ 0 Tw (-)Tj 0.218 Tw T* (\004\017\021\036\035\034\027\024 \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\017\035\036\024\f\021\024\n\024\005, \026)Tj /Span<>> BDC ( )Tj EMC (\017\n\036\027\027\024 \031)Tj /Span<>> BDC ( )Tj EMC (2 )Tj 0.14 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (73)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\017\035\036\024\f\021\024\n\024\005 \017)Tj /Span<>> BDC ( )Tj EMC (\027\017 \031)Tj /Span<>> BDC ( )Tj EMC (\024\007\027\024\020\024 \017)Tj /Span<>> BDC ( )Tj EMC (74 )Tj -0.012 Tw T* (\004\036\035\024\r\036\022 \f)Tj /Span<>> BDC ( )Tj EMC (\022\024\035\024\f\021\024\n\024\005 \(\210\221)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,32; 95% \212\236: 0,03\2263,14; )Tj /T1_0 1 Tf 0 Tw 0 -1.218 TD (\033)Tj /T1_1 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,33\) \(\217\017\f.)Tj /Span<>> BDC ( )Tj EMC (7\202\).)Tj 0.245 Tw 0 -1.218 TD (\215\024\035\031\004\036\027\027\t\036 \007\026\027\027\t\036 \017)Tj /Span<>> BDC ( )Tj EMC (\f\030\026\r\027\017\021\036\035\034\027\t\b \027\036\030\026\027\007\024\ \n\017)Tj 0 Tw (-)Tj 0.381 Tw T* (\017\030\024\r\026\027\027\t\b \017\f\f\035\036\007\024\r\026\027\017\005\ \023\024\022\026\t\r\026\033\021, \004\021\024 \023\024\f\035\036 )Tj 0.198 Tw T* (\235\024\030\n\017\030\024\r\026\027\017\016 \017\035\036\024\f\021\024\n\ \t \024\002\036\r\024\032\017\r\026\027\017\036 \030\026\r\017\r\026)Tj 0 Tw (-)Tj 0.129 Tw T* (\036\021\f\016 \004\026\013\036, \004\036\n \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\022\024\035\024\f\021\024\n\036 \(\210\221)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,23; 95% \212\236: )Tj 0 Tw T* (0,12\2260,45; )Tj /T1_0 1 Tf (\033)Tj /T1_1 1 Tf /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (0,00001\) \(\217\017\f.)Tj /Span<>> BDC ( )Tj EMC (7\207\).)Tj /T1_0 1 Tf 23.244 13.396 Td (\t\037\033\037\024\035\034\006\037\027\003\020\032\004 \037\025\024\007\016\ \024\024)Tj /T1_1 1 Tf 0.3 Tw T* (\200 \030\026\027\007\024\n\017\017\030\024\r\026\027\027\t\b \017\f\f\035\ \036\007\024\r\026\027\017\016\b \017\027\235\024\030\n\026\006\017\016 \ )Tj 0.25 Tw T* (\024)Tj /Span<>> BDC ( )Tj EMC (\007\026\027\027\024\n \024\f\035\024\032\027\036\027\017\017 \024\021\f\ \031\021\f\021\r\024\r\026\035\026. \215\030\017 \026\027\026\035\017\036\ )Tj 0.642 Tw T* (\f\030\026\r\027\017\021\036\035\034\027\t\b \027\036\030\026\027\007\024\ \n\017\017\030\024\r\026\027\027\t\b \017\f\f\035\036\007\024\r\026)Tj 0 Tw (-)Tj 0.121 Tw T* (\027\017\005 \027\026\002\035\033\007\026\035\026\f\034 \r\t\f\024\022\026\ \016 \020\036\021\036\030\024\020\036\027\027\024\f\021\034. \224\024\020\ \035\026\f\027\024 )Tj -0.005 Tw T* (\023\024\035\031\004\036\027\027\t\n \030\036\031\035\034\021\026\021\026\ \n, \030\026\035\017\004\017\005 \r)Tj /Span<>> BDC ( )Tj EMC (\004\026\f\021\024\021\036 \r\024\027\017\022)Tj 0 Tw (-)Tj 0.106 Tw 0 -1.218 TD (\027\024\r\036\027\017\016 \023\026\030\026\f\021\024\n\026\035\034\027\024\ \020\024 \026\002\f\006\036\f\f\026 \n\036\032\007\031 \020\030\031\023\023\ \026\n\017 )Tj 0.179 Tw 0 -1.218 TD (\r\t\016\r\035\036\027\024 \027\036 \002\t\035\024 \(\210\221)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,63; 95% \212\236: 0,09\2264,22; )Tj /T1_0 1 Tf 0 Tw T* (\033)Tj /T1_1 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,63\). \(\217\017\f.)Tj /Span<>> BDC ( )Tj EMC (8\).)Tj /T1_2 1 Tf 0 -2.436 TD (\200\002\213\240\b\t\r \002\217\f\002\202\b\r\b\t\235)Tj /T1_0 1 Tf 0 -1.218 TD (\207\035\033\022\021\035\023\033\037 \024\035\034\006\032)Tj /T1_1 1 Tf 0.059 Tw 0 -1.218 TD (\200 \004\036\021\t\030\036\b \f\030\026\r\027\017\021\036\035\034\027\t\ \b \027\036\030\026\027\007\024\n\017\017\030\024\r\026\027\027\t\b \017\ \f)Tj 0 Tw (-)Tj 0.311 Tw 0 -1.218 TD (\f\035\036\007\024\r\026\027\017\016\b \f\021\030\017\022\021\031\030\026\ \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\022\024\035\024\f\021\024\n\024\005 )Tj ET q /GS0 gs 453.543294 0 0 100.7873987 70.8661499 449.7533728 cm /Im0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0 Tw 9 0 0 9 70.8661 438.9534 Tm (\022\t\217\210\b\002\220 7\032.)Tj 0 0 0 1 k /GS1 gs /T1_0 1 Tf [( \240\025\016\031\036\034\201\022\036\037\020\022\016. \213\016\031\023\027\ \003\035\037\035\032 \033\037\020\b\034\006\022\031\022\033\034\036\037\020\ \020\032\002 \022\024\024\027\016\b)0.5(\034\036\037\020\022\004)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0 -1.2 TD [(F)-16(igure 7A)-14.9(.)]TJ 0 0 0 1 k /GS1 gs /T1_0 1 Tf [( Deh)12(y)14(dration. R)21.1(esults of)]TJ /Span<>> BDC ( )Tj EMC [(randomized tr)-36.7(ials)]TJ ET q /GS0 gs 453.543294 0 0 161.4998112 70.8661194 256.1496334 cm /Im1 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 9 0 0 9 70.8661 245.2688 Tm (\022\t\217\210\b\002\220 7\223.)Tj 0 0 0 1 k /GS1 gs /T1_0 1 Tf [( \240\025\016\031\036\034\201\022\036\037\020\022\016. \213\016\031\023\027\ \003\035\037\035\032 \024\033\037\036\020\022\035\016\027\003\020\032\002\ \020\016\033\037\020\b\034\006\022\031\022\033\034\036)0.5(\037\020\020\032\002 \022\024\024\027\016\b\034\036\037\020\022\004)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf T* [(F)-16(igure 7B.)]TJ 0 0 0 1 k /GS1 gs /T1_0 1 Tf [( Deh)12(y)14(dration. R)21.1(esults of)]TJ /Span<>> BDC ( )Tj EMC [(com)16.1(parativ)13.1(e non-randomized tr)-36.8(ials)]TJ ET q 70.866 101.101 453.543 122.864 re W n q /GS0 gs 453.543294 0 0 122.8646384 70.8661194 101.1002206 cm /Im2 Do Q Q BT 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 9 0 0 9 70.8661 90.1701 Tm (\022\t\217\210\b\002\220 8.)Tj 0 0 0 1 k /GS1 gs /T1_0 1 Tf [( \t\037\033\037\024\035\034\006\037\027\003\020\032\004 \037\025\024\007\ \016\024\024. \213\016\031\023\027\003\035\037\035\032 \024\033\037\036\020\ \022\035\016\027\003\020\032\002 \020)0.5(\016\033\037\020\b\034\006\022\031\022\033\034\036\037\020\020\032\002 \022\ \024\024\027\016\b\034\036\037\020\022\004)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf T* [(F)-16(igure 8.)]TJ 0 0 0 1 k /GS1 gs /T1_0 1 Tf [( P)18(arastomal abscess. R)21.2(esults of)]TJ /Span<>> BDC ( )Tj EMC [(com)16.1(parativ)13.1(e non-randomized tr)-36.8(ials)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\007\003\032)50(\n\n\217\n)-21(\035\030\002)]TJ 53.418 0 Td [(MET)30(A)-41(-)-41.9(ANAL)30(Y)30(SIS)]TJ -53.418 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 2)69(4, \023\0224, 202)23(5)]TJ 43.013 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 2)69(4, \023\0224, 202)23(5)]TJ /T1_4 1 Tf 25 0 0 25 20.7403 56.0378 Tm (158)Tj ET endstream endobj 1335 0 obj <>stream Adobed     '$''''$25552;;;;;;;;;;   %%#(((((#,0000,7;;;7;;;;;;;;;;   %%#(((((#,0000,7;;;7;;;;;;;;;;   %%#(((((#,0000,7;;;7;;;;;;;;;;<""  ^C !"#$%&'()*123456789:ABCDEFGHIJQRSTUVWXYZabcdefghijqrstuvwxyz!1AQqa"2bBU# $%&'()*3456789:CDEFGHIJRSTVWXYZcdefghijrstuvwxyz?"D@DD@DD@DD@DD@DD@DD@DD@DD@DD@DD@[1{Z J d( Šͱ&Uo3av gSe`\dusml[kvJwDvx/H~6{"c2cz>ϣ=pun5[Ŧs R4ƚ#kiod܍,@EΦz&BUr0u^Zl^OƴCjPe{w= "\5+0ڸZTPavM#cPq{3 C7^{[mOi+*l=FݽtCMQԭP.^ݦn;l8 - Y4&ZD z\I[(}:of5麘4 -SХ֧>(ڵ*2;C0uѽ8Ŗ;?dA뽵 E_vF#j7jxr3%sy͵=tE[A\[U]5,{NiD;j7y `ߠdUpN1ji l 0u-Wy{p=i{ R7]$ú|z"""""""""""""""""""""" 4XjT։$aVڔq @NMupaKexgdQ޴Ѻ9̞8F1Fj>8#P_ibiaY.f&b UL+/W:ws+vkjSxjmu}JtZj}'wM?;-XSeJ9[wqq[?TVV4 m^lx݄m ,ʅF"'39(jSa;W5,T)Dy@_dMϨ 1Uf5EZo56^@^R] :e`ƞ;t'Rեo7r@^Logil-W'[]SOh}a݆ټ/@DD@DD@DD@DD@DD@DD@DD@DD@DD@EyQpyqY^A#5jOck2i{IN6UզHs![llNMk 3פS_m8;Dzk[ViR.lM|l觽n=D<{t ; Dl} =.-tk1 tFQ($D@DD@DD@DD@DD@DD@DD@DD@Ъ"E>dNlmÈ=)9v{Lyc6n;x MuFVuj$;0g%K<Ǵm*< fF*J[F;ֆc=2Hq ;[)bjӣ|gaEOcK?~wZ :b82|Ѧj:s^ $FFaAmi{j5˄nߏD.>/jckq8 Typ[z(%ܭоfyqf<Ktus{n3K/Z*&j'y7 0 ,7pޤ 9x)+}u7UNas-wqxZ*(UnH*"d=|aq]W[8}g5 k.ڸ9bە*vaU0!j-6\E\-6`0ZsUMɂ<@\1SN%nt@hEe: f!ÿkR4ˢ@&opN b豮1Q4pkp}|̳Ƴo]q~F5q_zaPQbw^7t1_CGe6LouF1se9w7lPag;Me}W:h :p 1{-&nyֶb+2ZZnsp"c,[<"xZ崪aq4Rp h:(Xvq+nNdytNq+lN)U5jǼ2]ctmJA¹I1LCcl풽ǵG Q57u4̀>%AwgޮӭSU)N\tm f"&d,wc$99 wq?k7?wf0󜻊4Nez݊}J 7H˂.-CbݛPTs 6zTͩ+`~Va ^QS19Ee|}w15*2Pt u[/sq8S.ݫK{s$cx d:W:f&>KiK=gh*l;'Q-yXb@_* Fj'kc,F&Z` Xt0,aSyqqtjǙ`v'v*u:m{$̎me2:ocZ_CP+ 8LlL6'faqxzu#}BAhH"#W̽q8=zx,{0Tny<%r۵CqUEguhЙWbkb:GD-_G?HԤ(\KOܜ[wYkayul^ϻc(;3ЀN/_S5.h +,;FF5`p !v>gs**Qb^Z<"d1*GS0u:" E;[MSY i Yg]Lo$xNJ-/|pD} ^Ai 3+NdytNq*ٔ0"yy}H46=T_2l==U8Qj́@^|nkb[ٮWHjʅ7Fv_=`apeeXE`=(0p@oQaϳD8ݓػoh`h3 RԅBe--y;adE,14e:Lٮ ]T@DD@DD@DD@DD@D_u?l11-Տ Ƈ9}ҵݲqlT0W4*@-/;E'WkQ_Iy ܴp;+*.a4ahTu itg@_a?LjѦI%yh4Iף6<&1)bHj&]ͳ@^}0 J_I\bG'lq=A}vjab(M]9s3!ȉ6[!GLa 8F0hMpm ]V>G7stq[ⶮ;OYmG `%~&ou{bo8޴JVd`A7u6k叧-p{/f.:/ʮm*!#)cq4):e79,kisLG +^7ԣmCheñtoo4ZmiS)կkTExN` &B"64U>%hv98zeǸgil:6 Kʴ+mJdCf.#J̾ʥv-bE7o9۹11"ݭe;7TP-Ast"rTWTx8:Vfn7:@quNo4 [U6au:mk]8׻ܻI~|/-+N&եm3,Njʽu2MZ`H(_el3ըqga벡fmJX~gm we}0c{vZ, HѪ"u|^wkQZ 9]\QCo䓷;Eõ@_GCI&fҫGv:nk).s$٧lo|./K^e|n6wk$(~"| p":px݃k^4ݓ#XZ3i)`q|%Gbu6_`ybqP;[%=[.7ȇ"6XX\L;\o^#-4:ۭecuv+eW0*bU*5a$wRq}MI9Ǚ/n6wk$fv a2LT{7X_X^y]Roi]lu?I;qP;[$EX ٍSu70ϤY6-aCۻ*uu#aLC#r׋QCo䓷;Eõ@_I'~ؒʎkێ- .$9#[imC,W`k*h w@XU(~aݽGfS#z" pp;.:]I=q{[0a|~3/XaDz3"ZwA3n M.G̗ӷ;Eõ@_V45غ;)FbKOcۺe*~]uGF+a'.g{vKz{sE]*n9Kh,c} Su@6L49H15wdP$kVMc;Eõ@\$]lu?I;qP;[$E8lG 62be>b o`p~Í1 {;׃"@$_7ۍ'n6wk$Rb:g{;Kj1"uU{{f.[ZcuJa{iat YpqP;[$QCo$0֦ ꛮe\G%C`̡WPmg \UR ]p{qP;[$QCo S []&xg?a{(~vg{vH1G g?[N6xJ8mT>~ 0A7 n6wk$(~"?]ԧTCZC7n7n˛q?nq#b{-IeNR(~vg{vHvϚJŷ )w.ƛ@vbҼw{qP;[$QCo1K c_ԇy6=&٩P쭡Tm-eR \kƼn/;EõNlu?I}_M0NSaMw:H fW0݇k+0u<>R1;qw)_9ۍ'n6wk$wghٻu0(wFEָݵlЧwm7v6K=A7\7W;EõNlu?Iu|m=QԱGNÃeľ5w{qP;[$QCo~fq0_ ;r:L 2]X]y11`;!8\lu?I;qP;[$EME=0x*U5Th #zMl?fNŊe,]z41ŏ,\ֈ.k0(~vg{vHq^hcbc7(Ç q7JQCo䓷;Eõ@P'e<> |6{7Y侫9 p=;Gt7g{vIۍ /ifl :ԩwTEx 6}AvWRƴfxBlu?I;qP;[$E1}u6GSJ4i8٠DG2Rژ:'oa_TvlCpDM6"t|avs)og8Le0*'msM8$֮I'RwKW[;guN- { 5{n6wk$(~"l㰵jSM9ZI_qGvԪ [E1^zvg{vIۍ .{3m *}ӪR {&b 恭;'>Z xn{"LHQCo䓷;Eõ@_ANE_wĦa !{w t\3^ٛZh+`\ȌU D5^2$o(~"[?j`p{p5jvljw[' {kEJ>wokiҦw`n.lu?I;qP;[$EOCx_F4uרZDN=_غLదCHq#(QCo䓷;Eõ@_D6a_nඝJQ!P:kym ǖc)>74cL= +ۍ'n6wk$yكo`1} ;?H|a`Uw鹻d n6wk$vUnl׮`p݂"lmC¼w+uzvzHTmƻV+?AnwHTqP;[$QCo[jm*`SQHS?o[+E7%AUmֵ ۍ'n6wk$W K xT1MvDz푫NusccM]{g&H$H\lu?I;qP;[$EUY_L2ziCH*g{vIۍ ..n6wk$(~""g{vIۍ ..n6wk$(~""g{vIۍ +k0;Bxz%ͤMWuh71ΣI26oKVy3{u/QCo䓷;Eõ@]3gf67-xYPniٞh)c1uE ö{..и(~vg{vH4`` ,@`HR{` נr? 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R)21.1(esults of)]TJ /Span<>> BDC ( )Tj EMC [(randomized tr)-36.8(ials)]TJ ET q 42.52 304.524 453.543 198.454 re W n q /GS0 gs 453.543294 0 0 198.4551978 42.5196838 304.5237146 cm /Im1 Do Q Q BT 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 9 0 0 9 42.5197 293.6127 Tm (\022\t\217\210\b\002\220 5\223.)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf [( \t\016\033\022\024\035\034\006\037\027\003\020\032\004 \b\016\033\006\037\ \035\022\035. \213\016\031\023\027\003\035\037\035\032 \024\033\037\036\020\ \022\035\016\027\003\020)0.5(\032\002 \020\016\033\037\020\b\034\006\022\031\022\033\034\036\037\020\020\ \032\002 \022\024\024\027\016\b\034\036\037\020\022\004)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf T* [(F)-16(igure 5B.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf [( P)15(er)-37(istomal der)-13.8(matitis. R)21.1(esults of)]TJ /Span<>> BDC ( )Tj EMC [(com)16.1(parativ)13(e non-randomized tr)-37(ials)]TJ ET q 42.52 100.97 453.543 171.338 re W n q /GS0 gs 453.543294 0 0 171.3385777 42.5196838 100.9701686 cm /Im2 Do Q Q BT 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 9 0 0 9 42.5197 90.1702 Tm (\022\t\217\210\b\002\220 6.)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf [( \213\016\035\033\037\021\007\022\030 \024\035\034\006\032. \213\016\031\ \023\027\003\035\037\035\032 \024\033\037\036\020\022\035\016\027\003\020\ \032\002 \020\016\033\037\020\b\034\006\022\031\022\033\034\036)0.5(\037\020\020\032\002 \022\024\024\027\016\b\034\036\037\020\022\004)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0 -1.2 TD [(F)-16(igure 6)16.1(.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf [( S)28(toma retraction. R)21.2(esults of)]TJ /Span<>> BDC ( )Tj EMC [(com)16.1(parativ)13(e non-randomized tr)-36.8(ials)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\007\003\032)50(\n\n\217\n)-21(\035\030\002)]TJ 53.418 0 Td [(MET)30(A)-41(-)-41.9(ANAL)30(Y)30(SIS)]TJ /T1_4 1 Tf 25 0 0 25 505.5021 56.0378 Tm (157)Tj ET endstream endobj 1331 0 obj <>stream Adobed     '$''''$25552;;;;;;;;;;   %%#(((((#,0000,7;;;7;;;;;;;;;;   %%#(((((#,0000,7;;;7;;;;;;;;;;   %%#(((((#,0000,7;;;7;;;;;;;;;;<""   9U!126aqrs "#$%&'()*345789:ABCDEFGHIJQRSTUVWXYZbcdefghijtuvwxyz w !1AQaq"2bB# $%&'()*3456789:CDEFGHIJRSTUVWXYZcdefghijrstuvwxyz?"D@DD@DD@DD@DD@DD@DD@DD@DD@DD@DD@[1{Z J d( Šͱ&Uo3av gSe`\dusml[kwJwDvx/H~6{"c2cz>ϣ=pun5[Ŧs R4#kiot܍,@EΦzfBUr0u^Zl^OƴCjPe{w "\5+0ڸZTPavM#cPq{3 C7^{[mOi+*l=֏FݝtMQԭP.^ݦn;l8 - Y4&ZD z\I[(}:of5麘4-SKO٘|QiWQjjTdw6ay&z q-Wyv~oyP[I{j 5GfFn% c D~gJ/mj{hem:`we6sӺZA:{?=%~Qw4U0/lcVZeӹE /-,pZ@ׂɦ2#9W:GӦ9⁢L1Z^̞7W8| x'ilPq4K\:Ŗ<= 4ƈZx d=MUe,5*Tp kDJ0ԫTmJ8 VB:@\ 3PƗZ^JO _fmv#M(mGzQ̘P_ibiaY.f&b UL+/W:ws+vkjSxjmu}JtZj}'dNlm=)9v{Lyc6n;x MuFVuj$;0g%K<Ǵm*< fF*Xk>7ƀllʫZ#e֥!.WTq݈yi;p!|Q~hO&z,{sPϢzehdbm jss a-!+|2E =/@'[ /EF8VesIq!iZ eGqؖk7Da0ۡأ˝7w;~5kSݣ_'uᅮ ̖3 Vrr"]o^[DzcJc};C22%q^vǾhn229/llc1Xp*mr{G`b0kZ2t#7'xMv@T(l~pNko}=Ν.Ifk4+b82|Ѧj:s^ qÁtwQ~<q{Sk[T֙ˀJ݋v涙$meW,^;rhnNj"0\-9{&t .V~'7:@4 2\c3߇5eU^ 7x]1tXTsi`5q[hɾfY`Yu.#8@E= ]|0(u1U q:/#N7Tq:9朻l6A0ꇺP4zF lCjcVV֓7X"k[h1^zN7j9AE~e1_ K\rppټp[?̭rU08OĊLTqo4tE,n;w8'w<'8'kc*i\Xo1غ6j \ݤv^cݣlȌfNH}{O]>෫zTU}JS<6s:+[Gb;@b kƎc]\tEk7<.⺻/{^7baRi 2PcX7vT6 j|Ffڕ[?+0t{w)t"f2>js9 u[/sq8S.ݫK{s$`8 d9u]MM:xTS1}}ִE@_<>dۇvҥotuk{Z3!|B""yl_靆XI l;̮ ުqT? =E8Ey/]v9WxlӍNo2;:1lF kw@'u|/[Q؊TX[Ray! pFnԧ=0Zpژ'q,ז 73@_ vOnUC !5nEFڤ!&_QsC\@sfl,pj eJ wpv-,fpT$HoM["d_Ud>>KiK}u,C)b;^Ա˽hϰFB< AHG N=ڼff"1tIN?s2Ht͢0otuF;|눝h6&fhltֻqůww6"4_=f"s½j=}ZXv2/AS$ٯ EX=Z~*^*nh܌sUq+O-Aƾ{1-$E舀Ѫ"u|^wkQZ :]\cg}:(~E2z1?"}' &l\V5J鹮`d{DNjcf_ݽKҺht}-{yތlEȵOF6wӢZ /y;7 )Ӫj0M25kFm<,?V.ev1Zׇ`L/:Y|ߣ;C-o lT2s+kB(|capu0pv#izԌ-4;[ecuv+eW0*bU*5a$wRq}MI9ǩ/;C-oaL?fSqifk 0˺ [|Ӎbm+tP[dcg}:(~E2"l)ڃh`M:gyAs0ݕPl::}0]&!k1?"=NkLN7;%cZ\Hs0G ʵ[kavhXT /$."=NkLwoQٔ8ާ$< /˫mjl'Rkj}F^_6 |~Vgj1HLۂSn`8˥Q7>w8%cg}:(~E2"yٮԡH0Z{t)W|c<? 1]=F A9r|?;C-o T2s+i.X >lR#ꁮl:ZD$_lls(u5NtP[dEEcg}:(~E2z1?"}+ja?fQmo8 جub o`p~1k^5H =W1?"=NkLRb:g{wj1"uU{{f.[ZsuJa{iat YpNkLlEȵ@_[lZ;6nusI3[ 2\{]A+aqTMJNfZG1ucg}:(~E2z1?"P0߂as<cg}:(~E2z1?"O;h^:}«wҦO G pXԡ}0h&Rcg}:(~E2z1?"}V.vujS`*P~!!7n7oe8ퟃV7 81E=ր$2\')\F6wӢZ';C-o4;7Kn6}nR\76ţcg}:(~E2z1?"]:;kNHqcނm R1;qwI_9tP[dcg}:(~E2"mݞkwvqw]<ڵ/k`lEȵOF6wӢZ .m*#z#hB_u6qxplƮ;C-oэ?38 bJB\& x,.Uj<ʰH\.W;C-oэ0gl{# +y`jTIk@!F*,~UڝXhcX) \A"aq=NkLlEȵ@_cGS齱F?u`LrW;C-oэ3D콧6oto{>cg7\ f mW;dGsэtP[dEc>0PgP:2N㪞xo`fP[h2:xP TXւָ_5tP[dcg}:(~E2"ژ>:{/R f16h#ČiW(.MxH#:>hi;9xC&2x&LkW$;yٍiޝ3ߺPIyF=k\@pkэtP[dEٕaj;^sdbXZmo48 Xژe'Ҧ,`cI%p=NkLlEȵ@_V8 }5׼{iRkK\Mcg}:(~E2z1?"svVWj;̩^r lEȵOF6wӢZ ..;C-oэtP[dcg}:(~E2""1?"=NkLHlEȵOF6wӢZ +k0;Bxz%ͤMWuh71ΣI26oKVy3{v/cg}:(~E2z1?"t|mXJϠ(fBY%bfyhYxP;j^- tP[dcg}:(~E2"m6̭nTqxs\e_Q606V 9@|7:rOR^cg}:(~E2"8͏f67 Z`K*w\ijuo4[3ݴ)8&wΦj?F6wӢZ';C-o|ـՐ͙SQۮo~ZJVlT:x> 湥ͷ"o NkLlEȵ@_ESklMǷqKhw v|qXIۮD[q'flݕEz5%kL`yvBW?э*wSs+V5KI`!ŧ(Rڭ.TNg4W tdGV4̳eQi%A~Dfcg}:(~E2"m/4t`;q~' HP-kH{IuxW9BXZTH2j-:cg}:(~E2z1?"t>nnb>8ңO {>{.w,mq|#¥>g){~K\)EU1 *mEf_)q#º8]:j}wrxCi/@5w fӦ8OkӺh?Iw@E6'm` ;醢ËLrj9*85Rv~θ(b1 ݃ڮA>)լʸmZ Mqk,.#gb-SiZ"2'r0%Cժ4/ `ޘl\ [vUn\&{,:.>?K b<X q"5Vx| 2{.m.,v)5F*KBqan@3(ve|+C(c1_@ng9tNĵѦڎ;, ݵA߈44_Q4 c6u\Ie:n+9 w{zyB"vV"~NͧrOsި[7ycp*b`n=.K|0u15hЩ;1}Ysv+ >k*X\fg 5Vt]ü5]$&o\eۘ8M:Is[ð#Mp@DD@DD@DD@DD@DD@E3 پf-1N45ppWw_p8]I*7U`f6"eUۘ*{?WJwD78긊`  ؕ@DD@Saa:=ar&q8L>+ K(~")VIި;$a<Sw2] 5,C4:sm)ߓN"e,%,E1k+SMbwCSq0 LE/<GOv2XA͜_(lC Hej8<=_~@`KO U,30ץL Eq`nGt6 ~hhm| ؏zS\ژٸ 8'P{X5_JP)~^,n"a߸:j mȱAt0;6]P]9 6=pN;B:w}zNs= ZBv+UM,F˧F7@lv2p@T~â6{qx}iuz43 %Ă/2a9ZZ$m.UXl;yjnH6=*"5qk94m|@oݥ"Grm "" ,\@IkъRx%ѥ%EW Uh -+{5 N:)ɶY . }Qf" ԍڎi 2$A詯:wSvønǒCL4@2d [֣SQԪӨA [uZmi|C\;9=hhw Xڻݨ% .ZhnF9nk#QOY78Nb6n3 MЩJH{CLۮCkwzb:L;]o} " >W0'uS!ٸBßs8Ϫlr[vz9[3Wvs 3@r|=*OӦִI$Sb8ըwHyPUUpP5XXTXahO mb2o0CZY hfE2ݥ^i`K7=fB9 .-|' [VuCX*? 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)0.5(95% )]TJ 0.113 Tw -18.094 -1.218 Td (\212\236: 0,28\2269,94; )Tj /T1_1 1 Tf 0 Tw (\033)Tj /T1_0 1 Tf 0.113 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,57\) \(\217\017\f.)Tj /Span<>> BDC ( )Tj EMC (4\202\); \(\210\221)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,95; 95% )Tj 0 Tw T* (\212\236: 0,37\2262,46; )Tj /T1_1 1 Tf (\033)Tj /T1_0 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,92\) \(\217\017\f.)Tj /Span<>> BDC ( )Tj EMC (4\207\), \f\024\024\021\r\036\021\f\021\r\036\027\027\024.)Tj /T1_1 1 Tf 0 -2.436 TD (\t\016\033\022\024\035\034\006\037\027\003\020\032\004 \b\016\033\006\037\ \035\022\035)Tj /T1_0 1 Tf 0.464 Tw 0 -1.218 TD (\215\030\017 \017\031\004\036\027\017\017 \030\026\027\007\024\n\017\017\ \030\024\r\026\027\027\t\b \017\f\f\035\036\007\024\r\026\027\017\005, )Tj 0.418 Tw 0 -1.218 TD (\r\t\016\r\035\036\027\024, \004\021\024 \004\026\f\021\024\021\026 \030\ \026\r\017\021\017\016 \023\036\030\017\f\021\024\n\026\035\034\027\024\ \020\024 )Tj 0.654 Tw 23.244 15.831 Td [(\007\036\030\n\026\021\017\021\026 )0.6(\002\t\035\026 )0.5(\f\024\023\024\f\021\026\r\017\n\026 )0.6(\r)]TJ /Span<>> BDC ( )Tj EMC 15.563 0 Td [(\024\002\036\017\b )0.6(\020\030\031\023\023\026\b )]TJ 0 Tw -15.563 -1.218 Td (\(\210\221)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (1,19; 95% \212\236: 0,52\2262,75; )Tj /T1_1 1 Tf (\033)Tj /T1_0 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,68\) \(\217\017\f.)Tj /Span<>> BDC ( )Tj EMC (5\202\).)Tj 0.01 Tc 0.292 Tw 0 -1.218 TD (\200\n\036\f\021\036 \f)Tj /Span<>> BDC ( )Tj EMC [(\021\036\n, )0.5(\023\030\017)]TJ /Span<>> BDC ( )Tj EMC 8.707 0 Td [(\017\031\004\036\027\017\017 )0.5(\030\036\031\035\034\021\026\021\024\r \f\030\026\r\027\017)]TJ 0 Tc 0 Tw (-)Tj 0.01 Tc 0.367 Tw -8.707 -1.218 Td [(\021\036\035\034\027\t\b )0.5(\027\036\030\026\027\007\024\n\017\017\030\024\r\026\027\027\t\b )0.5(\017\f\f\035\036\007\024\r\026\027\017\005 )0.5(\024\021)]TJ 0 Tc 0 Tw (-)Tj 0.01 Tc 0.364 Tw T* (\n\036\004\026\035\026\f\034 \r\t\f\024\022\026\016 \020\036\021\036\030\ \024\020\036\027\027\024\f\021\034, \026)Tj /Span<>> BDC ( )Tj EMC [(\021\026\022\032\036 \002\t\035\024)10( )]TJ 0.336 Tw T* [(\024\021\n\036\004\036\027\024, \004\021\024 \004\026\f\021\024\021\026 \ \030\026\r\017\021\017\016 \023\036\030\017\f\021\024\n\026\035\034\027\ \024\020\024)10( )]TJ -0.042 Tw 0 -1.218 TD (\007\036\030\n\026\021\017\021\026 \002\t\035\026 \027\036\f\022\024\035\ \034\022\024 \r\t\001\036 \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\017\035\036\024)Tj 0 Tc 0 Tw (-)Tj 0.01 Tc 0.158 Tw 0 -1.218 TD [(\f\021\024\n\024\005, \024\007\027\026\022\024 \031\030\024\r\027\016 \f\ \021\026\021\017\f\021\017\004\036\f\022\024\005 \027\026\004\017\n\024\ \f\021\017)10( )]TJ -0.036 Tw T* (\027\036 \024\021\n\036\004\036\027\024 \(\210\221)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,56; 95% \212\236: 0,31\2261,02; )Tj /T1_1 1 Tf 0 Tc 0 Tw (p)Tj /T1_0 1 Tf 0.01 Tc -0.036 Tw /Span<>> BDC 19.091 0 Td ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC [(0,06\))10( )]TJ 0 Tw -19.091 -1.218 Td (\(\217\017\f.)Tj /Span<>> BDC ( )Tj EMC (5\207\).)Tj /T1_1 1 Tf 0 Tc 0 -2.436 TD (\213\016\035\033\037\021\007\022\030 \024\035\034\006\032)Tj /T1_0 1 Tf 0.007 Tw 0 -1.218 TD [(\200 \030\026\027\007\024\n\017\017\030\024\r\026\027\027\t\b )0.5(\017\f\f\035\036\007\024\r\026\027\017\016\b \007\026\027\027\024\036 )0.5(\024\f\035\024\032)]TJ 0 Tw (-)Tj 0.04 Tw 0 -1.218 TD (\027\036\027\017\036 \002\t\035\024 \023\030\036\007\f\021\026\r\035\036\ \027\024 \035\017\001\034 \r)Tj /Span<>> BDC ( )Tj EMC (\024\007\027\024\005 \030\026\002\024\021\036 \017)Tj /Span<>> BDC ( )Tj EMC (\r 9 )Tj ET q 70.866 437.128 453.543 110.824 re W n q /GS0 gs 453.543294 0 0 110.8661385 70.8661499 437.0866203 cm /Im0 Do Q Q BT 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0 Tw 9 0 0 9 70.8661 426.328 Tm (\022\t\217\210\b\002\220 3.)Tj 0 0 0 1 k /GS1 gs /T1_1 1 Tf [( \217\016\021\033\034\031 \024\035\034\006\032. \213\016\031\023\027\003\ \035\037\035\032 \024\033\037\036\020\022\035\016\027\003\020\032\002 \020\ \016\033\037\020\b\034\006\022\031\022)0.5(\033\034\036\037\020\020\032\002 \022\024\024\027\016\b\034\036\037\020\022\ \004)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0 -1.2 TD [(F)-16(igure 3.)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf [( S)28(toma necrosis. R)21.2(esults of)]TJ /Span<>> BDC ( )Tj EMC [(com)16.1(parativ)13(e non-randomized tr)-36.8(ials)]TJ ET q /GS0 gs 453.543294 0 0 130.7836515 70.8661194 274.2404268 cm /Im1 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 9 0 0 9 70.8661 263.3764 Tm (\022\t\217\210\b\002\220 4\032.)Tj 0 0 0 1 k /GS1 gs /T1_1 1 Tf ( \r\033\034\036\034\035\016\005\016\020\022\016 \022\031)Tj /Span<>> BDC ( )Tj EMC [(\024\035\034\006\032. \213\016\031\023\027\003\035\037\035\032 \033\037\020\ \b\034\006\022\031\022\033\034\036\037\020)0.5(\020\032\002 \022\024\024\027\016\b\034\036\037\020\022\004)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf T* [(F)-16(igure 4A)-14.9(.)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf [( S)28(toma bleeding. R)21.2(esults of)]TJ /Span<>> BDC ( )Tj EMC [(randomized tr)-36.8(ials)]TJ ET q /GS0 gs 453.543294 0 0 141.1023581 70.8661194 100.9700601 cm /Im2 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 9 0 0 9 70.8661 90.1701 Tm (\022\t\217\210\b\002\220 4\223.)Tj 0 0 0 1 k /GS1 gs /T1_1 1 Tf ( \r\033\034\036\034\035\016\005\016\020\022\016 \022\031)Tj /Span<>> BDC ( )Tj EMC [(\024\035\034\006\032. \213\016\031\023\027\003\035\037\035\032 \024\033\037\ \036\020\022\035\016\027\003\020\032\002 \020)0.5(\016\033\037\020\b\034\006\022\031\022\033\034\036\037\020\020\032\002 \022\ \024\024\027\016\b\034\036\037\020\022\004)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf T* [(F)-16(igure 4B.)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf [( S)28(toma bleeding. R)21.2(esults of)]TJ /Span<>> BDC ( )Tj EMC [(com)16.1(parativ)13(e non-randomized tr)-36.8(ials)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\007\003\032)50(\n\n\217\n)-21(\035\030\002)]TJ 53.418 0 Td [(MET)30(A)-41(-)-41.9(ANAL)30(Y)30(SIS)]TJ -53.418 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 2)69(4, \023\0224, 202)23(5)]TJ 43.013 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 2)69(4, \023\0224, 202)23(5)]TJ /T1_4 1 Tf 25 0 0 25 20.7277 56.0378 Tm (156)Tj ET endstream endobj 1327 0 obj <>stream Adobed     '$''''$25552;;;;;;;;;;   %%#(((((#,0000,7;;;7;;;;;;;;;;   %%#(((((#,0000,7;;;7;;;;;;;;;;   %%#(((((#,0000,7;;;7;;;;;;;;;;<""  J?!"12QRSaq #$%&'()*3456789:ABCDEFGHIJTUVWXYZbcdefghijrstuvwxyz}!1AQaq"2BURb #$%&'()*3456789:CDEFGHIJSTVWXYZcdefghijrstuvwxyz?"D@DD@DD@DD@DD@DD@DD@DD@DD@DD@DD@[1ւ8I$T'J:\sxfkmZ X{sdm [YB}JwD΀xSyHa_16} GQ`]-R ҭ`a 6iŽcBlNk]@m|XkM ܍2"S{=Kg! 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\(\024\016\026)11(\001\001\215\001\t\021\213\022\021\022\b\021\b)-10(\026)11(\016\024\001\026\021\f\016\b\017\021\207 \025\235\213\025\201 \t\021\026\ )11(\016\201\001\026)-20(\200\201\220\))]TJ 41.159 1 Td [(Pr)31(e)11(v)12(entiv)12.1(e intestinal stoma: ileostom)21(y)31(, colostom)21(y)52(. )]TJ -4.661 -1 Td [(W)30(hich\022option\022is\022safer? \(meta-analy)10(sis and s)10(y)10(stematic r)31(e)11(vie)11(w\))]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0.001 Tw 10 0 0 10 274.9606 408.2019 Tm [(R)-24(isk of)]TJ /Span<>> BDC ( )Tj EMC [(bias in non-r)-32.9(and)-16(omized studies)]TJ /Span<>> BDC ( )Tj EMC (\227 of)Tj /Span<>> BDC ( )Tj EMC [(E)35(xposur)-23.9(es )]TJ 0.021 Tw 0 -1.218 TD (\(ROBINS-E\). \200)Tj /Span<>> BDC ( )Tj EMC (\030\036\031\035\034\021\026\021\036 \023\030\024\r\036\007\036\027\027\ \024\020\024 \026\027\026\035\017\026 \f\031\n)Tj 0 Tw (-)Tj 0.282 Tw T* (\n\026\030\027\024\020\024 \030\017\f\022\026 \f\017\f\021\036\n\026\021\ \017\004\036\f\022\024\005 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133.3701 Tm (\022\t\217\210\b\002\220 2.)Tj 0 0 0 1 k /GS1 gs /T1_4 1 Tf ( \240\007\016\020\021\037 \033\022\024\021\037 \024\006\016\235\016\020\022\ \030 \036)Tj /Span<>> BDC ( )Tj EMC (\033\037\020\b\034\006\022\031\022\033\034\036\037\020\020\032\002 )Tj 0.102 Tw 0 -1.2 TD (\022\024\024\027\016\b\034\036\037\020\022\030\002, \024\033\037\036\020\ \022\036\037\026\235\022\002 \033\016\031\023\027\003\035\037\035\032 \017\ \034\033\006\022\033\034\036\037\020\022\030 )Tj 0 Tw T* (\022\027\016\034\024\035\034\006\032 \022)Tj /Span<>> BDC ( )Tj EMC (\021\034\027\034\024\035\034\006\032)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf -0.031 Tw T* [(F)-16(igure )0.5(2)15.9(.)]TJ 0 0 0 1 k /GS1 gs /T1_4 1 Tf [( )0.5(Assess)33(ment of)]TJ /Span<>> BDC ( )Tj EMC [(the r)-36.9(isk of)]TJ /Span<>> BDC ( )Tj EMC (displacement in randomized )Tj 0.012 Tw T* [(tr)-37(ials com)16(par)-37(ing the)]TJ /Span<>> BDC ( )Tj EMC (results of)Tj /Span<>> BDC ( )Tj EMC [(ileostom)11.1(y and colostom)11(y for)-13.9(ma)]TJ 0 Tw (-)Tj T* (tion)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0.203 Tw 0 72.346 TD (\020\004\206\f\t\204\004 1.)Tj 0 0 0 1 k /GS1 gs /T1_4 1 Tf ( \212\037\033\037\021\035\016\033\022\024\035\022\021\037 \024\033\037\036\ \020\022\035\016\027\003\020\032\002 \033\037\020\b\034\006\022\031\022\033\ \034\036\037\020\020\032\002 \022)Tj /Span<>> BDC ( )Tj EMC (\020\016\033\037\020\b\034\006\022\031\022\033\034\036\037\020\020\032\002\ \022\024\024\027\016\b\034\036\037\020\022\004, \036\021\027\026\005\016\ \020\020\032\002 )Tj 0 Tw 0 -1.2 TD (\036)Tj /Span<>> BDC ( )Tj EMC (\006\016\035\037\037\020\037\027\022\031)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf -0.027 Tc 0.027 Tw T* [(T)0.5(a)-35.3(b)-40.7(l)-38.7(e)-27( 1)-24.5(.)]TJ 0 0 0 1 k /GS1 gs /T1_4 1 Tf 0 Tc 0 Tw 3.324 0 Td [( C)-1.1(ha)-4.2(r)3.3(a)-9.1(c)-32.4(t)-1.6(e)-6(r)-39(i)7.9(z)8.4(a)-9.2(t)-29.1(i)-1.4(o)-3.9(n o)4(f)]TJ /Span<>> BDC ( )Tj EMC [(c)2.8(o)-4(m)-1(p)-6.3(a)-4.1(r)3.3(a)-9.2(t)-29.1(i)-2.9(v)2.3(e r)3.3(a)-5.1(n)-4.7(d)-5.3(o)-4(m)1.3(i)7.9(z)7.9(e)-12.9(d a)-5.1(n)-4.7(d n)-2.4(o)-4(n)-13.4(-)-12.1(r)3.3(a)-5.1(n)-4.8(d)-5.3(o)-3.9(m)1.3(i)7.9(z)7.9(e)-12.9(d s)-14.8(t)-1.1(u)-5.9(d)-2.9(i)-1.4(e)-22(s i)3.9(n)-2.9(c)-1.1(lu)-5.9(d)-5.3(e)-12.9(d i)3.9(n t)-10.6(h)-2.4(e)]TJ /Span<>> BDC ( )Tj EMC [(m)-5.3(e)-8.5(t)-2(a)-3.2(a)-5.1(na)-4.5(l)6.6(y)-5.3(s)-12.5(i)6.6(s)]TJ ET 0 0 0 1 K 0.5 w /GS2 gs q 1 0 0 1 42.5197 704.381 cm 0 0 m 96.628 0 l S Q q 1 0 0 1 42.7697 692.9117 cm 0 0 m 0 11.219 l S Q q 1 0 0 1 139.1476 704.381 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 139.1476 692.9117 cm 0 0 m 0 11.219 l S Q q 1 0 0 1 184.502 704.381 cm 0 0 m 79.37 0 l S Q q 1 0 0 1 184.502 692.9117 cm 0 0 m 0 11.219 l S Q q 1 0 0 1 263.872 704.381 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 263.872 692.9117 cm 0 0 m 0 11.219 l S Q q 1 0 0 1 354.5807 704.381 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 354.5807 692.9117 cm 0 0 m 0 11.219 l S Q q 1 0 0 1 399.935 704.381 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 399.935 693.1617 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 448.124 704.381 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 496.313 693.1617 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 42.7697 681.6926 cm 0 0 m 0 11.219 l S Q q 1 0 0 1 139.1476 681.6926 cm 0 0 m 0 11.219 l S Q q 1 0 0 1 184.502 681.6926 cm 0 0 m 0 11.219 l S Q q 1 0 0 1 263.872 681.6926 cm 0 0 m 0 11.219 l S Q q 1 0 0 1 354.5807 681.6926 cm 0 0 m 0 11.219 l S Q q 1 0 0 1 399.685 692.9117 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 399.935 681.6926 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 448.124 692.9117 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 448.124 681.6926 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 496.313 681.6926 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 42.5197 681.4426 cm 0 0 m 96.628 0 l S Q q 1 0 0 1 42.7697 670.2313 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 139.1476 681.4426 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 139.1476 670.2313 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 184.502 681.4426 cm 0 0 m 79.37 0 l S Q q 1 0 0 1 184.502 670.2313 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 263.872 681.4426 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 263.872 670.2313 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 354.5807 681.4426 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 354.5807 670.2313 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 399.935 681.4426 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 399.935 670.2313 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 448.124 681.4426 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 448.124 670.2313 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 670.2313 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 669.9813 cm 0 0 m 96.628 0 l S Q q 1 0 0 1 42.7697 658.77 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 139.1476 669.9813 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 139.1476 658.77 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 184.502 669.9813 cm 0 0 m 79.37 0 l S Q q 1 0 0 1 184.502 658.77 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 263.872 669.9813 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 263.872 658.77 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 354.5807 669.9813 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 354.5807 658.77 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 399.935 669.9813 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 399.935 658.77 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 448.124 669.9813 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 448.124 658.77 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 658.77 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 658.52 cm 0 0 m 96.628 0 l S Q q 1 0 0 1 42.7697 647.3008 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 139.1476 658.52 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 139.1476 647.3008 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 184.502 658.52 cm 0 0 m 79.37 0 l S Q q 1 0 0 1 184.502 647.3008 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 263.872 658.52 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 263.872 647.3008 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 354.5807 658.52 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 354.5807 647.3008 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 399.935 658.52 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 399.935 647.3008 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 448.124 658.52 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 448.124 647.3008 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 496.313 647.3008 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 42.5197 647.0508 cm 0 0 m 96.628 0 l S Q q 1 0 0 1 42.7697 635.8315 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 139.1476 647.0508 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 139.1476 635.8315 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 184.502 647.0508 cm 0 0 m 79.37 0 l S Q q 1 0 0 1 184.502 635.8315 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 263.872 647.0508 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 263.872 635.8315 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 354.5807 647.0508 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 354.5807 635.8315 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 399.935 647.0508 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 399.935 635.8315 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 448.124 647.0508 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 448.124 635.8315 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 496.313 635.8315 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 42.5197 635.5815 cm 0 0 m 96.628 0 l S Q q 1 0 0 1 42.7697 624.3702 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 139.1476 635.5815 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 139.1476 624.3702 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 184.502 635.5815 cm 0 0 m 79.37 0 l S Q q 1 0 0 1 184.502 624.3702 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 263.872 635.5815 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 263.872 624.3702 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 354.5807 635.5815 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 354.5807 624.3702 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 399.935 635.5815 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 399.935 624.3702 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 448.124 635.5815 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 448.124 624.3702 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 624.3702 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 624.1202 cm 0 0 m 96.628 0 l S Q q 1 0 0 1 42.7697 612.9011 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 139.1476 624.1202 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 139.1476 612.9011 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 184.502 624.1202 cm 0 0 m 79.37 0 l S Q q 1 0 0 1 184.502 612.9011 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 263.872 624.1202 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 263.872 612.9011 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 354.5807 624.1202 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 354.5807 612.9011 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 399.935 624.1202 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 399.935 612.9011 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 448.124 624.1202 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 448.124 612.9011 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 496.313 612.9011 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 42.5197 612.6511 cm 0 0 m 96.628 0 l S Q q 1 0 0 1 42.7697 601.4398 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 139.1476 612.6511 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 139.1476 601.4398 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 184.502 612.6511 cm 0 0 m 79.37 0 l S Q q 1 0 0 1 184.502 601.4398 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 263.872 612.6511 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 263.872 601.4398 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 354.5807 612.6511 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 354.5807 601.4398 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 399.935 612.6511 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 399.935 601.4398 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 448.124 612.6511 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 448.124 601.4398 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 601.4398 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 601.1898 cm 0 0 m 96.628 0 l S Q q 1 0 0 1 42.7697 589.9705 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 139.1476 601.1898 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 139.1476 589.9705 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 184.502 601.1898 cm 0 0 m 79.37 0 l S Q q 1 0 0 1 184.502 589.9705 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 263.872 601.1898 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 263.872 589.9705 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 354.5807 601.1898 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 354.5807 589.9705 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 399.935 601.1898 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 399.935 589.9705 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 448.124 601.1898 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 448.124 589.9705 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 496.313 589.9705 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 42.5197 589.7205 cm 0 0 m 96.628 0 l S Q q 1 0 0 1 42.7697 578.5093 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 139.1476 589.7205 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 139.1476 578.5093 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 184.502 589.7205 cm 0 0 m 79.37 0 l S Q q 1 0 0 1 184.502 578.5093 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 263.872 589.7205 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 263.872 578.5093 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 354.5807 589.7205 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 354.5807 578.5093 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 399.935 589.7205 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 399.935 578.5093 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 448.124 589.7205 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 448.124 578.5093 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 578.5093 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 578.2593 cm 0 0 m 96.628 0 l S Q q 1 0 0 1 42.7697 567.048 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 139.1476 578.2593 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 139.1476 567.048 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 184.502 578.2593 cm 0 0 m 79.37 0 l S Q q 1 0 0 1 184.502 567.048 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 263.872 578.2593 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 263.872 567.048 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 354.5807 578.2593 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 354.5807 567.048 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 399.935 578.2593 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 399.935 567.048 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 448.124 578.2593 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 448.124 567.048 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 567.048 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 566.798 cm 0 0 m 96.628 0 l S Q q 1 0 0 1 42.7697 555.5867 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 139.1476 566.798 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 139.1476 555.5867 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 184.502 566.798 cm 0 0 m 79.37 0 l S Q q 1 0 0 1 184.502 555.5867 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 263.872 566.798 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 263.872 555.5867 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 354.5807 566.798 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 354.5807 555.5867 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 399.935 566.798 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 399.935 555.5867 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 448.124 566.798 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 448.124 555.5867 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 555.5867 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 555.3367 cm 0 0 m 96.628 0 l S Q q 1 0 0 1 42.7697 544.1254 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 139.1476 555.3367 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 139.1476 544.1254 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 184.502 555.3367 cm 0 0 m 79.37 0 l S Q q 1 0 0 1 184.502 544.1254 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 263.872 555.3367 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 263.872 544.1254 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 354.5807 555.3367 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 354.5807 544.1254 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 399.935 555.3367 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 399.935 544.1254 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 448.124 555.3367 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 448.124 544.1254 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 544.1254 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 543.8754 cm 0 0 m 96.628 0 l S Q q 1 0 0 1 42.7697 532.6641 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 139.1476 543.8754 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 139.1476 532.6641 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 184.502 543.8754 cm 0 0 m 79.37 0 l S Q q 1 0 0 1 184.502 532.6641 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 263.872 543.8754 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 263.872 532.6641 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 354.5807 543.8754 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 354.5807 532.6641 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 399.935 543.8754 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 399.935 532.6641 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 448.124 543.8754 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 448.124 532.6641 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 532.6641 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 532.4141 cm 0 0 m 96.628 0 l S Q q 1 0 0 1 42.7697 521.1949 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 139.1476 532.4141 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 139.1476 521.1949 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 184.502 532.4141 cm 0 0 m 79.37 0 l S Q q 1 0 0 1 184.502 521.1949 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 263.872 532.4141 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 263.872 521.1949 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 354.5807 532.4141 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 354.5807 521.1949 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 399.935 532.4141 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 399.935 521.1949 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 448.124 532.4141 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 448.124 521.1949 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 496.313 521.1949 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 42.5197 520.9449 cm 0 0 m 96.628 0 l S Q q 1 0 0 1 42.7697 509.7336 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 139.1476 520.9449 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 139.1476 509.7336 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 184.502 520.9449 cm 0 0 m 79.37 0 l S Q q 1 0 0 1 184.502 509.7336 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 263.872 520.9449 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 263.872 509.7336 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 354.5807 520.9449 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 354.5807 509.7336 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 399.935 520.9449 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 399.935 509.7336 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 448.124 520.9449 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 448.124 509.7336 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 509.7336 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 509.4836 cm 0 0 m 96.628 0 l S Q q 1 0 0 1 42.7697 498.2723 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 139.1476 509.4836 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 139.1476 498.2723 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 184.502 509.4836 cm 0 0 m 79.37 0 l S Q q 1 0 0 1 184.502 498.2723 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 263.872 509.4836 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 263.872 498.2723 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 354.5807 509.4836 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 354.5807 498.2723 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 399.935 509.4836 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 399.935 498.2723 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 448.124 509.4836 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 448.124 498.2723 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 498.2723 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 498.0223 cm 0 0 m 96.628 0 l S Q q 1 0 0 1 42.7697 486.811 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 139.1476 498.0223 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 139.1476 486.811 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 184.502 498.0223 cm 0 0 m 79.37 0 l S Q q 1 0 0 1 184.502 486.811 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 263.872 498.0223 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 263.872 486.811 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 354.5807 498.0223 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 354.5807 486.811 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 399.935 498.0223 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 399.935 486.811 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 448.124 498.0223 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 448.124 486.811 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 486.811 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 486.561 cm 0 0 m 96.628 0 l S Q q 1 0 0 1 42.7697 475.3498 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 139.1476 486.561 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 139.1476 475.3498 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 184.502 486.561 cm 0 0 m 79.37 0 l S Q q 1 0 0 1 184.502 475.3498 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 263.872 486.561 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 263.872 475.3498 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 354.5807 486.561 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 354.5807 475.3498 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 399.935 486.561 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 399.935 475.3498 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 448.124 486.561 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 448.124 475.3498 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 475.3498 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 475.0998 cm 0 0 m 96.628 0 l S Q q 1 0 0 1 42.7697 463.8885 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 139.1476 475.0998 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 139.1476 463.8885 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 184.502 475.0998 cm 0 0 m 79.37 0 l S Q q 1 0 0 1 184.502 463.8885 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 263.872 475.0998 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 263.872 463.8885 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 354.5807 475.0998 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 354.5807 463.8885 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 399.935 475.0998 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 399.935 463.8885 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 448.124 475.0998 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 448.124 463.8885 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 463.8885 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 463.6385 cm 0 0 m 96.628 0 l S Q q 1 0 0 1 42.7697 452.4272 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 139.1476 463.6385 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 139.1476 452.4272 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 184.502 463.6385 cm 0 0 m 79.37 0 l S Q q 1 0 0 1 184.502 452.4272 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 263.872 463.6385 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 263.872 452.4272 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 354.5807 463.6385 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 354.5807 452.4272 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 399.935 463.6385 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 399.935 452.4272 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 448.124 463.6385 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 448.124 452.4272 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 452.4272 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 452.1772 cm 0 0 m 96.628 0 l S Q q 1 0 0 1 139.1476 452.1772 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 184.502 452.1772 cm 0 0 m 79.37 0 l S Q q 1 0 0 1 263.872 452.1772 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 354.5807 452.1772 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 399.935 452.1772 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 448.124 452.1772 cm 0 0 m 48.439 0 l S Q BT /GS1 gs /T1_3 1 Tf 8 0 0 8 80.7148 690.0118 Tm (\032\003\002\006)Tj 8.5 0 Td (\200\r\006\t\002\240)Tj 7.967 0 Td (\255\003\006\004\b\004 )Tj 11.338 0 Td (\020\t\212)Tj 7.83 0.6 Td (\016\220\004\f\004 )Tj -0.475 -1.2 Td (\220\004\201\r\217\003\004)Tj 8.036 1.317 Td (N \212\004\204\t\r\b\003\002)Tj -0.938 -1.434 Td (LC)Tj 4.664 0 0 4.664 426.6848 686.9412 Tm (*)Tj 8 0 0 8 466.2454 684.2772 Tm (LI)Tj 4.664 0 0 4.664 473.0052 686.9412 Tm (**)Tj /T1_1 1 Tf 8 0 0 8 45.6043 672.8159 Tm (Caparlar M.A. [11])Tj 13.528 0 Td (2022)Tj 7.342 0 Td (\230\031\030\006\017\016)Tj 8.545 0 Td (\217\036\021\030\024\f\023\036\022\021\017\r\027\024\036)Tj 11.792 0 Td (8)Tj 5.596 0 Td (40)Tj 6.024 0 Td (50)Tj -52.827 -1.433 Td (Caricato M. [12])Tj 13.528 0 Td (2007)Tj 7.328 0 Td (\236\021\026\035\017\016)Tj 8.559 0 Td (\217\036\021\030\024\f\023\036\022\021\017\r\027\024\036)Tj 11.792 0 Td (6)Tj 5.596 0 Td (77)Tj 6.024 0 Td (44)Tj -52.827 -1.433 Td (Edwards D.P. [13])Tj 13.528 0 Td (2001)Tj 5.377 0 Td (\200\036\035\017\022\024\002\030\017\021\026\027\017\016)Tj /T1_3 1 Tf 9.572 -0.001 Td (\022\004\b\240\002\214\t\213\t\006\002\004\b\b\002\r)Tj /T1_1 1 Tf 12.702 0.001 Td (\226)Tj 5.624 0 Td (36)Tj 6.024 0 Td (34)Tj -52.827 -1.434 Td (Gooszen A.W. [14])Tj 13.528 0 Td (1998)Tj 6.219 0 Td (\203\017\007\036\030\035\026\027\007\t)Tj /T1_3 1 Tf 8.73 -0.001 Td (\022\004\b\240\002\214\t\213\t\006\002\004\b\b\002\r)Tj /T1_1 1 Tf 12.702 0.001 Td (\226)Tj 5.624 0 Td (39)Tj 6.024 0 Td (37)Tj -52.827 -1.434 Td (Gastinger I. [15])Tj 13.528 0 Td (2005)Tj 6.826 0 Td (\206\036\030\n\026\027\017\016)Tj 9.44 0 Td (\215\030\024\f\023\036\022\021\017\r\027\024\036)Tj 11.413 0 Td (8)Tj 5.596 0 Td (30)Tj 6.024 0 Td (76)Tj -52.827 -1.433 Td (Khoury G.A. [16])Tj 13.528 0 Td (1987)Tj 5.377 0 Td (\200\036\035\017\022\024\002\030\017\021\026\027\017\016)Tj /T1_3 1 Tf 9.572 -0.001 Td (\022\004\b\240\002\214\t\213\t\006\002\004\b\b\002\r)Tj /T1_1 1 Tf 12.702 0.001 Td (\226)Tj 5.624 0 Td (29)Tj 6.024 0 Td (32)Tj -52.827 -1.434 Td (Klink C.D. [17])Tj 13.528 0 Td (2011)Tj 6.826 0 Td (\206\036\030\n\026\027\017\016)Tj 9.061 0 Td (\217\036\021\030\024\f\023\036\022\021\017\r\027\024\036)Tj 11.792 0 Td (8)Tj 5.346 0 Td (100)Tj 6.024 0 Td (100)Tj -52.577 -1.433 Td (Law W.L. [18])Tj 13.528 0 Td (2002)Tj 7.576 0 Td (\025\017\021\026\005)Tj /T1_3 1 Tf 7.373 -0.001 Td (\022\004\b\240\002\214\t\213\t\006\002\004\b\b\002\r)Tj /T1_1 1 Tf 12.702 0.001 Td (\226)Tj 5.624 0 Td (38)Tj 6.024 0 Td (42)Tj -52.827 -1.434 Td (Mala T. [19])Tj 13.528 0 Td (2008)Tj 6.838 0 Td (\203\024\030\r\036\020\017\016)Tj 9.049 0 Td (\217\036\021\030\024\f\023\036\022\021\017\r\027\024\036)Tj 11.792 0 Td (8)Tj 5.596 0 Td (10)Tj 6.024 0 Td (62)Tj -52.827 -1.433 Td (Prassas D. [20])Tj 13.528 0 Td (2020)Tj 6.826 0 Td (\206\036\030\n\026\027\017\016)Tj 9.061 0 Td (\217\036\021\030\024\f\023\036\022\021\017\r\027\024\036)Tj 11.792 0 Td (8)Tj 5.596 0 Td (93)Tj 6.024 0 Td (55)Tj -52.827 -1.433 Td (Rullier E. [21])Tj 13.528 0 Td (2001)Tj 6.991 0 Td (\205\030\026\027\006\017\016)Tj 8.896 0 Td (\217\036\021\030\024\f\023\036\022\021\017\r\027\024\036)Tj 11.792 0 Td (7)Tj 5.596 0 Td (60)Tj 5.774 0 Td (107)Tj -52.577 -1.433 Td (Sakai Y. [22])Tj 13.528 0 Td (2001)Tj 7.258 0 Td (\233\023\024\027\017\016)Tj 8.629 0 Td (\217\036\021\030\024\f\023\036\022\021\017\r\027\024\036)Tj 11.792 0 Td (7)Tj 5.596 0 Td (63)Tj 6.024 0 Td (63)Tj -52.827 -1.433 Td (Sun X. [23])Tj 13.528 0 Td (2019)Tj 7.576 0 Td (\025\017\021\026\005)Tj 8.311 0 Td (\217\036\021\030\024\f\023\036\022\021\017\r\027\024\036)Tj 11.792 0 Td (7)Tj 5.346 0 Td (111)Tj 6.274 0 Td (66)Tj -52.827 -1.433 Td (Williams N.S. [24])Tj 13.528 0 Td (1986)Tj 5.377 0 Td (\200\036\035\017\022\024\002\030\017\021\026\027\017\016)Tj /T1_3 1 Tf 9.572 -0.001 Td (\022\004\b\240\002\214\t\213\t\006\002\004\b\b\002\r)Tj /T1_1 1 Tf 12.702 0.001 Td (\226)Tj 5.624 0 Td (24)Tj 6.024 0 Td (23)Tj -52.827 -1.434 Td (Wu X. [25])Tj 13.528 0 Td (2018)Tj 7.576 0 Td (\025\017\021\026\005)Tj 8.311 0 Td (\217\036\021\030\024\f\023\036\022\021\017\r\027\024\036)Tj 11.792 0 Td (6)Tj 5.346 0 Td (109)Tj 6.274 0 Td (77)Tj -52.827 -1.433 Td (Yang Y. [26])Tj 13.528 0 Td (2023)Tj 7.13 0 Td (\230\026\005\r\026\027\034)Tj 8.757 0 Td (\217\036\021\030\024\f\023\036\022\021\017\r\027\024\036)Tj 11.792 0 Td (7)Tj 5.346 0 Td (176)Tj 6.024 0 Td (234)Tj -52.577 -1.433 Td (\202\035\017\036\r \236.\236. [27])Tj 13.528 0 Td (2023)Tj 7.358 0 Td (\217\024\f\f\017\016)Tj 8.529 0 Td (\217\036\021\030\024\f\023\036\022\021\017\r\027\024\036)Tj 11.792 0 Td (7)Tj 5.346 0 Td (243)Tj 6.024 0 Td (110)Tj -52.577 -1.433 Td (\200\024\030\024\002\034\036\r \206.\236. [28])Tj 13.528 0 Td (2007)Tj 7.358 0 Td (\217\024\f\f\017\016)Tj 8.529 0 Td (\217\036\021\030\024\f\023\036\022\021\017\r\027\024\036)Tj 11.792 0 Td (8)Tj 5.596 0 Td (82)Tj 5.774 0 Td (117)Tj -52.577 -1.433 Td (\212\026\030\002\017\001\020\026\007\032\017\036\r \221.\210. [29])Tj 13.528 0 Td (2020)Tj 7.358 0 Td (\217\024\f\f\017\016)Tj 8.529 0 Td (\217\036\021\030\024\f\023\036\022\021\017\r\027\024\036)Tj 11.792 0 Td (7)Tj 5.596 0 Td (52)Tj 6.024 0 Td (37)Tj -52.827 -1.433 Td (\224\036\r\024\f\021\034\016\027\024\r \224.\236. [30])Tj 13.528 0 Td (2005)Tj 7.358 0 Td (\217\024\f\f\017\016)Tj 8.529 0 Td (\217\036\021\030\024\f\023\036\022\021\017\r\027\024\036)Tj 11.792 0 Td (6)Tj 5.596 0 Td (65)Tj 5.774 0 Td (112)Tj /T1_4 1 Tf 7 0 0 7 42.5197 440.6926 Tm (\t\033\022\006\016\005\037\020\022\016: *LC)Tj /Span<>> BDC ( )Tj EMC (\227 loop colostoma; **LI)Tj /Span<>> BDC ( )Tj EMC (\227 loop ileostoma)Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\007\003\032)50(\n\n\217\n)-21(\035\030\002)]TJ 53.418 0 Td [(MET)30(A)-41(-)-41.9(ANAL)30(Y)30(SIS)]TJ /T1_5 1 Tf 25 0 0 25 505.3897 56.0378 Tm (155)Tj ET endstream endobj 1368 0 obj <>stream Adobed     '$''''$25552;;;;;;;;;;   ####''',,,   ####''',,,   ####''',,,2""   1A!Q2aq"3BR #$ %&'()*456789:CDEFGHIJSTUVWXYZbcdefghijrstuvwxyz !1"AQa2Bq#CRbr $%&'()*3456789:DEFGHIJSTUVWXYZcdefghijstuvwxyz?@0DDDD@DDDDD@DDDDD@DDDDD@DDDDD@DDDDD@DDDDD@DDDDWn%i>jyϦ$t(opwH@EE4j%{ """"" """"" """"" """@0DDDD@DDDDD@DDDDD@DDDDD@DDDDD@DDDDD@DDDDD@DDD^_Y:\Z U/r|rV*Q5jT NiUutn]=΀ּ%-2>)c} NbX<̽0 (" """"" """"Mq^4Gl)жkիRTq-. m.JtFޭ']JUH(o(\M'mv۾{+v7%o+9#+M y9{k[>KSeI\0LĒI;@0DDDD@DDDDD@DDDDD@DDDDD@DDDDD@DDDDD@DDDDD@DDD[6ԷᴛV|vm[]uڼ.8s9$}8.^,i]LmIڈn9^P_v+;fv"jZnB/ 5i\^喎թQ .Z@^uz$s/nhz&[6jmJCF\5tѩf+\P/[/ 4jbΛM7MA\E@0DDDD@DDDDD@DDDDD@DDDDD@DDDDE :8]v4֐mp tt@Ek?uiPTVN2E QCCl.%B^Yݶt[JJ :*1"=ޝJ4h>P溥b+ n%C䫩꽦Sgld5wi4=eB[ x} kni7KG=C sN" """"" """"vҵZkJբH(S#X`Dac_'ӽ Ϊʔؾ$)$z7P WltC;Ӓ6i")Rm-~ ݕm?[{{vV(6ajxP@Do\;.n +z5-E}L3;䝕{}}iAi{׸5wiF0z^/G*IfֵK3ِ=7@EW^zҩRեqRT[0V^migA I "g64PmZ\9ֺƩpsA483 $>{"+Z MX{m ]t^E7Q:""" "/ªE_QM-& 4tjM.\Ș26+/smswa}^6Q4KKeӞX~QU%{VͧVU,275\ ` % Vvm5j;SˈU`""""" """"" @0DDDD@DDDDD@DDDDD@DDDDD@DDDE鼖N 5q*kMVtgeW~O][ ksDZkiչsQڌk:lZ-*֯e n[tr2/Mll+w?p- k^esDD@DDDDD@DDD^~ykYR.!$7}m-/iۚWmRv\%q,鶕g֪WVf*5aaZIRݹPX\ж`uZv }l58x@EϑǓJ[W:!gRX%TjbcGeOmuCT4*-lUxvAn9gqgs^ jU(m+jt.~L{켤m.66-mMo`inC:<>\:靝Ft5vFZH?8iB ,i.h:5mxX\z'u'OҘ+HMHԀ76!RGp.DIXkOSt14]ѷvƐΑ޳@0DDDD@DDDDD@DDDDD@DDDDD@DDDE ]6biBꦫY͐dy鼘᷷FEt-y js_!I܌`op^-Pu WMn&U{dA4޽>^ʻ~{Om:i1[' ^EǓϷVϼiUhRYi;7KH"N Tn+p-k>JntVOPvmqno>wjBRxf5.xA1l{Gz)t+7fAss "稈բ.`Զ.Mp[GwKyǂ+y;cQ.+_V@ 1:Xdj)o)][pګn8b\i:5n v+ͯA-8/B6M;/>@0DDDD@DDDDD@DDDDD@DDDDD@DDDE,(>}_BH>:5Z+o.8}[:Ѧmd7OlqoR}O^I㫹 #weW<&c9f0) 6ax$DD@DEWm. 8k)Ψь%[ĸ~M֡}@IfV_\FG,_+6WIsm{έ m6гmpV]k@c<"˛o@qؐ4"`XoWgBBS"Eh<"H:@ܾƭ;x%*- c˚g d>|uVtZj.p-F;""ٯ}|5AZ0iθ-i8wWKdږyC+¥+rחU54PW5(B l\8h7V=&^σAZ֍{oGҚZc kK\y]{EQhW" ZNGfqwY wKV[7pM=^[s9ƣj9a """"" """"" @0DDDD@DDDDD@DDDDD@DDDDD@DDDE_pk|DQ Zful/8/Jڝ,Ȥ-;k]Uxh?J޸i\0i mC4$IKqۛJ& @QPVyL4V-i "" "z+w܋z*Rꆍ`PH$8 Bѭkx%q­/֦bXu5&}q֗w65EkZϡT鸱w3{!^P1%ݝgLҋIsC5Ťcr[n%kfqo} ůQFgZz+\Bofܵx9q[q[׳oeoDv9p \;%O⣼YU4P- n~Ӭ//m8*5K׽4{:cKKj4 ^ U孎vF_= -u2PxTD@D_tUitL dʷ.U,Z^ ֐Hti].jӲG] `hsN^[0Ӓyt=|DmIĭXl轴ʵe\Ft^S[+iqwDƻ-ha"""q:. {ju:%)?c0cTKcCUsԸ}[RaTvaޖgx(|k2>֛]N{j*u*y&NH$J&rzii݅zcwNYA ˉ8 őߺU0 S깮onƆy$ax,eΣM:..lj?XWo/+V=CcEqqZ꣫W\HkAŮci0:*1 oAƸ%kZU|8Z[ԬE8%/ g shR.sg}R:dT/R\>ՔYC =ifp +z?&8}j5o*ھ{˜`C  +Q620q62Q&`if`uj#Iܮf-'cx#Nέ;ZunCA4ݲHEFq"|[4*E.sA!E58 mZV41CDi sX>Q <^h\vM14f RmhW 7ouunqޡ@DDD[<R7VW,n)I:Ym8q2E/cnx}bDQQe䀗6 6-w@w|-n!Oipnx_5T ,`2I" """.NӎXT6T= qnUiѩXUPΚ-,,80YTnm" )!JQ<> U]~ߦa*6=VcsBCoĭFҪ紴pqp.lǓU.+TmKZVVϯ^WF"\gXW߶2,NǗQtj)$/cWYԶixjvnfΉ>n˝yEx}FuMSB+]ѠKɐJ< :K']?pݛ_4Ii|CCOGy^{ull-YwǙR_on4Z;76wly:j=8 }eW4|9ހ=uJ޵\2S-u:"ѧ {#.m-¨]Vs\a͊dgcU_'Zox l/4W-KX \7s .kPbދ7TѪ! 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I{Z'<٭9<7S_Q/Hyk"A wH1; m /:os6sIi!kq(8-Tm-c: ⱑG48)I%\6 FJW lpeHjT2FZ>R!^&6ҏ~o 澔~>[}@rnoPk/CC<@0DDDD@DDDDD@DDDDD@DDDDD@D^ƅ N/퍟JҽÞ˪R4Ȁ~+!'G9¿BH~+!'G9¿BH> kn7Nڰ{+ ԷM\׬9´լa$Hs5(8WCORs~;5(8WCORs~; w᝵;.΍`h陑ܲ> J?AD^ԣ_!> J?AD^ԣ_!W¼8Ye: ,p&`;׏D^Êy?m}}uuOpˋ]9R|~+!/4/G9¿B|~+!/4/G9¿Bg o᝵N ݹѡ:gT//G9¿B|~+!/4/G9¿B|~+!/4]V4+p5鼁p88&'w{GN@ 0׋D^ԣ_!> J?AD^ԣ_!> J?AD^ۄ5ovw6\ըA3jQp " w jQp " w Oj,{\x t3ߕT/8{jIf2iƒQ DD@0DDDD@DDDDD@DDDDD@DDDDD@DDDDD@DDDDD@DDDDD@DDDDD@DDDDD@DDDDD@DDDDD@DDDDD@DDDDD@DDDDD@DDD endstream endobj 1369 0 obj <>stream endstream endobj 1365 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.211 Tw 10 0 0 10 70.8661 724.8299 Tm (\r\t\f\024\021\026 \030\026\f\023\024\035\024\032\036\027\017\016 \022\024\ \035\024\030\036\022\021\026\035\034\027\024\020\024 \026\027\026\f\021\024\ \n\024\026, )Tj 0.041 Tw 0 -1.218 TD (\023\030\024\r\036\007\036\027\017\036 \027\036\024\026\007\255\033\r\026\ \027\021\027\024\005 \b\017\n\017\024\035\031\004\036\r\024\005 \021\036\ \030\026\023\017\017, )Tj 0.091 Tw T* (\027\026\004\036\027\017\016 \001\022\026\035\t \024\006\036\027\022\017\ \030\017\f\022\026 \203\202)Tj /Span<>> BDC ( )Tj EMC (\017)Tj /Span<>> BDC ( )Tj EMC (\n\027\024\032\036\f\021\r\024 \007\030\031)Tj 0 Tw (-)Tj T* (\020\017\b \235\026\022\021\024\030\024\r [5\2267].)Tj 0.014 Tw T* (\212\024 \f\036\020\024\007\027\016\001\027\036\020\024 \007\027\016 \027\ \036 \f\031\013\036\f\021\r\031\036\021 \017\007\036\026\035\034\027\t\b\ \n\036\021\024)Tj 0 Tw (-)Tj 0.041 Tw T* (\007\024\r, \023\024\r\024\035\016\033\013\017\b \031\n\036\027\034\001\ \017\021\034 \004\026\f\021\024\021\031 \203\202. \210\007\027\026\022\024\ \n\t )Tj -0.001 Tw 0 -1.218 TD [(\n\024\032\036\n )0.5(\023\024\r\035\017\016\021\034 )0.6(\027\026)]TJ /Span<>> BDC ( )Tj EMC [(\021\016\032\036\f\021\034 )0.6(\022\035\017\027\017\004\036\f\022\017\b )0.6(\023\030\024\016\r\035\036\027\017\005 )]TJ 0.158 Tw 0 -1.218 TD (\023\030\017)Tj /Span<>> BDC ( )Tj EMC (\030\026\r\017\021\017\017 \027\036\f\024\f\021\024\016\021\036\035\034\ \027\024\f\021\017 \023\031\021\036\n \235\024\030\n\017\030\024\r\026)Tj 0 Tw (-)Tj 0.007 Tw T* (\027\017\016 \023\030\036\r\036\027\021\017\r\027\024\005 \022\017\001\036\ \004\027\024\005 \f\021\024\n\t, \027\026\035\017\004\017\036 \022\024\021\ \024\030\024\005 )Tj -0.026 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\027\036\022\024\021\024\030\t\b \f\017\021\031\026\006\017\016\b \023\024\ \r\024\035\016\036\021 \f\023\026\f\021\017 \032\017\027\034 \023\026\006\ \017)Tj 0 Tw (-)Tj T* (\036\027\021\031 [8].)Tj 0.177 Tw T* (\200\024\023\030\024\f \024)Tj /Span<>> BDC ( )Tj EMC (\r\t\002\024\030\036 \r\026\030\017\026\027\021\026 \023\030\036\r\036\027\ \021\017\r\027\024\005 \f\021\024\n\t)Tj /Span<>> BDC ( )Tj EMC (\227 )Tj 0.048 Tw 0 -1.218 TD (\017\035\036\024\f\021\024\n\026 \017\035\017 \022\024\035\024\f\021\024\ \n\026)Tj /Span<>> BDC ( )Tj EMC (\227 \024\f\021\026\036\021\f\016 \023\030\036\007\n\036\021\024\n \027\026\ )Tj 0 Tw (-)Tj -0.03 Tw 0 -1.218 TD (\031\004\027\024\020\024 \f\023\024\030\026 \017)Tj /Span<>> BDC ( )Tj EMC (\024\002\f\031\032\007\036\027\017\005 \r)Tj /Span<>> BDC ( )Tj EMC (\b\017\030\031\030\020\017\004\036\f\022\024\n \f\024\024\002\013\036)Tj 0 Tw (-)Tj 0.148 Tw 0 -1.218 TD (\f\021\r\036, \027\036\f\n\024\021\030\016 \027\026)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\034\001\024\036 \022\024\035\017\004\036\f\021\r\024 \023\031\ \002\035\017\022\026\006\017\005. )Tj 0.392 Tw T* (\200)Tj /Span<>> BDC ( )Tj EMC (\007\026\027\027\024\n \n\036\021\026\026\027\026\035\017\036 \017\f\f\035\ \036\007\024\r\026\027\026 \002\036\024\023\026\f\027\024\f\021\034 )Tj 0.073 Tw T* (\017\f\023\024\035\034\024\r\026\027\017\016 \023\030\036\r\036\027\021\ \017\r\027\t\b \f\021\024\n: \017\035\036\024\f\021\024\n\t \017)Tj /Span<>> BDC ( )Tj EMC (\022\024)Tj 0 Tw (-)Tj 0.28 Tw T* (\035\024\f\021\024\n\t \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\027\017\022\017\n\017 \022\024\035\024\030\036\022\021\026\035\034\027\ \t\n\017 )Tj 0 Tw T* (\026\027\026\f\021\024\n\024\026\n\017.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 70.936 469.0918 Tm (\017\034\r\237)Tj 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0 Tc 0.057 Tw 10 0 0 10 70.8661 444.7358 Tm (\224\030\026\r\027\017\021\034 \004\026\f\021\024\021\031 \030\026\r\017\ \021\017\016 \030\026\027\027\017\b \017)Tj /Span<>> BDC ( )Tj EMC (\023\024\007\027\017\b \024\f\035\024\032)Tj 0 Tw (-)Tj 0.078 Tw T* (\027\036\027\017\005 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\235\024\030\n\017\030\024\r\026\027\017\017 \017)Tj /Span<>> BDC ( )Tj EMC (\026\022\030\t\021\017\017 \023\030\036\r\036\027\021\017\r\027\t\b )Tj 0.056 Tw T* (\017\035\036\024\f\021\024\n \017)Tj /Span<>> BDC ( )Tj EMC (\022\024\035\024\f\021\024\n, \026)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\032\036 \024\023\030\036\007\036\035\017\021\034, \022\026\022\ \024\005 \r\017\007 )Tj 0.002 Tw T* (\022\017\001\036\004\027\024\005 \f\021\024\n\t \002\036\024\023\026\f\027\ \036\036 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\235\024\030\n\017\030\024\r\026\027\017\017 \027\017)Tj 0 Tw (-)Tj T* (\022\024\020\024 \022\024\035\024\030\036\022\021\026\035\034\027\024\020\ \024 \026\027\026\f\021\024\n\024\026.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0.01 Tc 0.018 Tw 14 0 0 14 70.936 359.4898 Tm [(\240)21(\026)45(\024\034\033\031\026)-10(\r\232)5( \031)5(\016)-18.3(\240\034)-31(\024)35(\037\226\232)]TJ 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0 Tc 0.178 Tw 10 0 0 10 70.8661 335.1338 Tm (\204\036\021\026\026\027\026\035\017 \r\t\023\024\035\027\036\027 \r)Tj /Span<>> BDC ( )Tj EMC (\f\024\024\021\r\036\021\f\021\r\017\017 \f)Tj /Span<>> BDC ( )Tj EMC (\030\036\022\024\n\036\027\007\026)Tj 0 Tw (-)Tj 0.019 Tw T* [(\006\017\016\n\017 T)47(he)]TJ /Span<>> BDC ( )Tj EMC [(p)25(r)-24(efer)-24(r)-23.9(ed r)-24(epor)-21.9(t)-32(ingi tems for sy)-13(stema)15.1(t)-32(ic r)-24(e)]TJ 0 Tw (-)Tj -0.011 Tw T* [(v)-16(iews and me)-11.9(t)15(a-anal)35(y)-13(ses \(PRISMA\) [9]. \215\024\017\f\022 \027\026\031\004\027\t\b )]TJ 0.026 Tw T* (\030\026\002\024\021 \023\030\024\r\024\007\017\035\f\016 \r)Tj /Span<>> BDC ( )Tj EMC (\220\035\036\022\021\030\024\027\027\t\b \002\026\026\b \n\036\007\017\006\ \017\027\f\022\024\005 )Tj 0.187 Tw T* [(\035\017\021\036\030\026\021\031\030\t P)20(ubMed \017)]TJ /Span<>> BDC ( )Tj EMC [(El)-31(ibr)-32.9(ar)-24(y. \025\035\033\004\036\r\t\036 \f\035\024\r\026: il)]TJ 0 Tw (-)Tj 0.219 Tw T* [(eost)17(omy, col)30(ost)17.1(omy; l)30(o)-16(op ileost)17(omy, l)30(o)-16(op col)30(ost)17(omy; )]TJ 0.244 Tw T* [(tem)10(por)-33(ar)-23.9(y st)17(oma; com)10(pl)-31(ica)15(t)-32(ions. \230\026\022\032\036 \023\030\024\r\024\007\017\035\f\016 )]TJ 0.142 Tw T* [(\007\024\023\024\035\027\017\021\036\035\034\027\t\005 )0.5(\023\024\017\f\022 \023\024)]TJ /Span<>> BDC ( )Tj EMC (\002\017\002\035\017\024\020\030\026\235\017\004\036\f\022\017\n \007\026\ \027)Tj 0 Tw (-)Tj 0.14 Tw T* (\027\t\n \f\030\036\007\017 \r\022\035\033\004\036\027\027\t\b \r)Tj /Span<>> BDC ( )Tj EMC (\n\036\021\026\026\027\026\035\017 \017\f\f\035\036\007\024\r\026\027\017\ \005 )Tj 0.13 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\006\036\035\034\033 \r\t\016\r\035\036\027\017\016 \023\030\024\023\031\ \013\036\027\027\t\b \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\r\024\027\026\004\026\035\034)Tj 0 Tw (-)Tj 0.172 Tw T* (\027\024\n \023\024\017\f\022\036 \f\021\026\021\036\005. \200)Tj /Span<>> BDC ( )Tj EMC (\n\036\021\026\026\027\026\035\017 \r\022\035\033\004\036\027\t \023\024\ \035\027\024)Tj 0 Tw (-)Tj 0.196 Tw T* (\021\036\022\f\021\024\r\t\036 \f\021\026\021\034\017 \027\026)Tj /Span<>> BDC ( )Tj EMC (\026\027\020\035\017\005\f\022\024\n \017)Tj /Span<>> BDC ( )Tj EMC (\030\031\f\f\022\024\n \016\t\022\026\b, )Tj 0.184 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\022\024\021\024\030\t\b \024\021\030\026\032\036\027 \b\026\030\026\022\ \021\036\030 \024\f\035\024\032\027\036\027\017\005, \r\024\027\017\022\ \026)Tj 0 Tw (-)Tj 0.303 Tw T* (\033\013\017\b \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\017\f\023\024\035\034\024\r\026\027\017\017 \017)Tj /Span<>> BDC ( )Tj EMC (\035\017\022\r\017\007\026\006\017\017 \017\035\036\024\f\021\024\n )Tj 0 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\022\024\035\024\f\021\024\n.)Tj 0.409 Tw T* (\210\f\035\024\032\027\036\027\017\016, \f\r\016\026\027\027\t\036 \f)Tj /Span<>> BDC ( )Tj EMC (\027\026\035\017\004\017\036\n \f\021\024\n\t, \002\t\035\017 )Tj 0.184 Tw T* (\030\026\f\023\030\036\007\036\035\036\027\t \027\026)Tj /Span<>> BDC ( )Tj EMC (\030\026\027\027\017\036 \017)Tj /Span<>> BDC ( )Tj EMC (\023\024\007\027\017\036. \230\026\022, \022)Tj /Span<>> BDC ( )Tj EMC (\030\026\027\027\017\n )Tj 0.175 Tw T* (\024\f\035\024\032\027\036\027\017\016\n \024\021\027\036\f\035\017: \027\ \036\022\030\024 \f\021\024\n\t, \022\030\024\r\024\021\036\004\036\027\ \017\036 )Tj -0.027 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\f\021\024\n\t, \023\026\030\026\f\021\024\n\026\035\034\027\t\005 \026\002\ \f\006\036\f\f, \030\036\021\030\026\022\006\017\033 \f\021\024\n\t, )Tj 0.028 Tw T* (\024\002\036\r\024\032\017\r\026\027\017\036 \017)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\017\f\021\024\n\026\035\034\027\t\005 \007\036\030\n\026\021\ \017\021. \025)Tj /Span<>> BDC ( )Tj EMC (\023\024\007)Tj 0 Tw (-)Tj 0.323 Tw T* [(\027\017\n )0.5(\002\t\035\017 )0.6(\024\021\027\036\f\036\027\t )0.5(\f\035\036\007\031\033\013\017\036: )0.5(\f\021\030\017\022\021\031\030\026 )0.5(\f\021\024\n\t, )]TJ 0.023 Tw T* (\023\030\024\035\026\023\f \f\021\024\n\t \017)Tj /Span<>> BDC ( )Tj EMC (\023\026\030\026\f\021\024\n\026\035\034\027\026\016 \020\030\t\032\026.\ \230\026\022\032\036 \002\t\035\017 )Tj 0.345 Tw 23.244 64.543 Td (\023\030\024\026\027\026\035\017\017\030\024\r\026\027\t \024\f\035\024\ \032\027\036\027\017\016, \f\r\016\026\027\027\t\036 \f)Tj /Span<>> BDC ( )Tj EMC (\035\017\022)Tj 0 Tw (-)Tj 0.102 Tw 0 -1.218 TD (\r\017\007\026\006\017\036\005 \f\021\024\n\t: \023\024\f\035\036\024\023\ \036\030\026\006\017\024\027\027\026\016 \020\030\t\032\026 \r)Tj /Span<>> BDC ( )Tj EMC (\024\002\035\026)Tj 0 Tw (-)Tj 0.164 Tw 0 -1.218 TD (\f\021\017 \f\021\024\n\t, \030\026\027\036\r\026\016 \017\027\235\036\022\ \006\017\016 \017)Tj /Span<>> BDC ( )Tj EMC (\020\036\n\026\021\024\n\026 \023\036\030\036\007\027\036\005 )Tj 0.272 Tw 0 -1.218 TD (\002\030\033\001\027\024\005 \f\021\036\027\022\017, \022\017\001\036\004\ \027\026\016 \027\036\023\030\024\b\024\007\017\n\024\f\021\034, \027\036\ \f\024)Tj 0 Tw (-)Tj 0 -1.218 TD (\f\021\024\016\021\036\035\034\027\024\f\021\034 \022\024\035\024\030\036\ \022\021\026\035\034\027\024\020\024 \026\027\026\f\021\024\n\024\026.)Tj -0.029 Tw 0 -1.218 TD (\215\030\017 \023\024\017\f\022\036 \035\017\021\036\030\026\021\031\030\ \t \r)Tj /Span<>> BDC ( )Tj EMC [(P)20(ubMed \017)]TJ /Span<>> BDC ( )Tj EMC [(El)-31(ibr)-32.9(ar)-24(y \002\t\035\024 \027\026\005)]TJ 0 Tw (-)Tj 0 -1.218 TD (\007\036\027\024 337 \023\031\002\035\017\022\026\006\017\005 \026)Tj /Span<>> BDC ( )Tj EMC (\023\024\f\035\036\007\027\017\036 30 \035\036\021 \(\217\017\f.)Tj /Span<>> BDC ( )Tj EMC (1\).)Tj 0.156 Tw 0 -1.218 TD (\200 \007\026\035\034\027\036\005\001\036\n \002\t\035\017 \017\f\022\035\ \033\004\036\027\t \024\002\024\030\t \035\017\021\036\030\026\021\031\030\ \t )Tj 0.395 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\n\036\032\031\021\024\004\027\t\036 \030\036\031\035\034\021\ \026\021\t \030\026\027\007\024\n\017\017\030\024\r\026\027\027\t\b )Tj 0.074 Tw T* (\022\035\017\027\017\004\036\f\022\017\b \017\f\f\035\036\007\024\r\026\027\ \017\005. \200)Tj /Span<>> BDC ( )Tj EMC (\030\036\031\035\034\021\026\021\036 \024\021\002\024\030\026 \035\017)Tj 0 Tw (-)Tj 0.028 Tw T* (\021\036\030\026\021\031\030\t \r)Tj /Span<>> BDC ( )Tj EMC (\n\036\021\026\026\027\026\035\017 \r\022\035\033\004\036\027\024 5 \030\ \026\027\007\024\n\017\017\030\024\r\026\027)Tj 0 Tw (-)Tj -0.006 Tw T* (\027\t\b \017\f\f\035\036\007\024\r\026\027\017\005 \017)Tj /Span<>> BDC ( )Tj EMC (15 \f\030\026\r\027\017\021\036\035\034\027\t\b \027\036\030\026\027\007\ \024\n\017\017)Tj 0 Tw (-)Tj 0.257 Tw T* [(\030\024\r\026\027\027\t\b )0.5(\017\f\f\035\036\007\024\r\026\027\017\005, )0.5(\023\024\f\r\016\013\036\027\027\t\b )0.6(\030\036\031\035\034\021\026\021\026\n )]TJ 0 Tw T* (\035\036\004\036\027\017\016 \023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\017\035\036\024\f\021\024\n\026\n\017 \017)Tj /Span<>> BDC ( )Tj EMC (\022\024\035\024\f\021\024\n\026\n\017.)Tj 0.501 Tw T* (\025\024\027\036\004\027\t\n\017 \021\024\004\022\026\n\017 \n\036\021\026\ \026\027\026\035\017\026 \016\r\035\016\035\017\f\034: \030\026\027)Tj 0 Tw (-)Tj 0.133 Tw T* (\027\017\036 \017)Tj /Span<>> BDC ( )Tj EMC (\023\024\007\027\017\036 \023\024\f\035\036\024\023\036\030\026\006\017\ \024\027\027\t\036 \024\f\035\024\032\027\036\027\017\016 \023\024)Tj 0 Tw (-)Tj 0.354 Tw T* (\f\035\036 \235\024\030\n\017\030\024\r\026\027\017\016 \f\021\024\n\t \017\ )Tj /Span<>> BDC ( )Tj EMC (\030\036\022\024\027\f\021\030\031\022\021\017\r\027\024-\r\024\f)Tj 0 Tw (-)Tj 0.221 Tw T* (\f\021\026\027\024\r\017\021\036\035\034\027\t\b \024\023\036\030\026\006\ \017\005 \f)Tj /Span<>> BDC ( )Tj EMC (\035\017\022\r\017\007\026\006\017\036\005 \017\035\036\024\f\021\024\n \ )Tj 0 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\022\024\035\024\f\021\024\n.)Tj /T1_2 1 Tf 0 -2.436 TD (\026\b\020\b\007\017\b\007\006\005\017\004\007\003 \020\002\020\001\007\ )Tj /T1_0 1 Tf 0.12 Tw 0 -1.218 TD (\224\021\026\021\017\f\021\017\004\036\f\022\017\005 \026\027\026\035\017\  \023\030\024\r\024\007\017\035\f\016 \f)Tj /Span<>> BDC ( )Tj EMC (\017\f\023\024\035\034\024\r\026\027\017)Tj 0 Tw (-)Tj 0.083 Tw T* [(\036\n \023\030\024\020\030\026\n\n\t )0.5(R)13(ev)-16(iew Mana)-17(ger )0.5(\(R)13(evMan\) V)30(er)-9.9(sion 5.4. )]TJ -0.089 Tw T* [(T)47(he)]TJ /Span<>> BDC ( )Tj EMC [(Co)-16(chr)-33(ane Coll)-16(abor)-33(a)15(t)-32(ion, 2020. \224\031\n\n\026\030\027\024\036 \027\026\004\036\027\017\036\ )]TJ 0.159 Tw T* (\007\017\b\024\021\024\n\017\004\036\f\022\017\b \007\026\027\027\t\b \024\ \023\017\f\026\027\024 \r)Tj /Span<>> BDC ( )Tj EMC (\r\017\007\036 \024\021\027\024\001\036\027\017\016 )Tj -0.031 Tw T* (\001\026\027\f\024\r \(\210\221\) \f)Tj /Span<>> BDC ( )Tj EMC (95% \007\024\r\036\030\017\021\036\035\034\027\t\n \017\027\021\036\030\r\ \026\035\024\n \(\212\236\). )Tj -0.032 Tw T* (\210\221 \030\026\f\f\004\017\021\t\r\026\035\017 \023\024)Tj /Span<>> BDC ( )Tj EMC [(\n\036\021\024\007\031 P)30(e)-12(t)17(o, \036\f\035\017 \024\007\027\024 \017)]TJ /Span<>> BDC ( )Tj EMC (\027\026\004\036)Tj 0 Tw (-)Tj 0.068 Tw T* [(\027\017\005 )0.5(\004\036\021\t\030\036\b\023\024\035\034\027\024\005 )0.6(\021\026\002\035\017\006\t )0.5(\030\026\r\027\016\035\024\f\034 )0.6(0, )0.5(\030\026\035\017\004\017\016 )]TJ 0.276 Tw T* (\f\004\017\021\026\035\017\f\034 \f\021\026\021\017\f\021\017\004\036\f\022\ \017 \027\026\004\017\n\t\n\017 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\027\026\004\036\027\017\017 )Tj /T1_3 1 Tf 0 Tw T* (p)Tj /T1_0 1 Tf -0.025 Tw /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (0,05. \224\021\026\021\017\f\021\017\004\036\f\022\031\033 \020\036\021\036\ \030\024\020\036\027\027\024\f\021\034 \f\030\036\007\017 \017\f\f\035\036\ )Tj 0 Tw (-)Tj 0.041 Tw T* (\007\024\r\026\027\017\005 \024\006\036\027\017\r\026\035\017 \f)Tj /Span<>> BDC ( )Tj EMC (\023\024\n\024\013\034\033 \260)Tj 0 Tw 5.83 0 0 5.83 441.907 362.8198 Tm (2)Tj 0.041 Tw 10 0 0 10 444.822 359.4898 Tm ( \021\036\f\021\026. \200\027\036 \026\r\017\f\017)Tj 0 Tw (-)Tj -0.005 Tw -14.152 -1.218 Td (\n\024\f\021\017 \024\021 \031\030\024\r\027\016 \020\036\021\036\030\024\ \020\036\027\027\024\f\021\017 \f\021\030\024\017\035\017\f\034 \n\024\007\ \036\035\017 \f\024 )Tj 0.078 Tw T* (\f\035\031\004\026\005\027\t\n \220\235\235\036\022\021\024\n. \224\021\026\ \021\017\f\021\017\004\036\f\022\017 \027\026\004\017\n\024\005 \020\036\ \021\036)Tj 0 Tw (-)Tj T* (\030\024\020\036\027\027\024\f\021\034\033 \f\004\017\021\026\035\017 I)Tj 5.83 0 0 5.83 397.2454 326.2858 Tm (2)Tj /Span<>> BDC 10 0 0 10 400.1603 322.9558 Tm ( )Tj EMC (>)Tj /Span<>> BDC ( )Tj EMC (50% \017)Tj /Span<>> BDC ( )Tj EMC /T1_3 1 Tf (\033)Tj /T1_0 1 Tf /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (0,05.)Tj /T1_2 1 Tf -9.685 -2.436 Td (\037\020\006\005\017\b\206\217 \007\017\017\001\005\235\217\206\020\002\007\ \003)Tj /T1_0 1 Tf 0.449 Tw T* [(\025\026\004\036\f\021\r\024 )0.5(\r\022\035\033\004\036\027\027\t\b )0.6(\030\026\027\007\024\n\017\017\030\024\r\026\027\027\t\b )0.6(\017\f\f\035\036)]TJ 0 Tw (-)Tj 0.065 Tw T* [(\007\024\r\026\027\017\005 )0.5(\002\t\035\024 \024\006\036\027\036\027\024 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC [(\f\024\024\021\r\036\021\f\021\r\017\017 )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC (\022\030\017\021\036\030\017\016\n\017 )Tj ET q 303.307 100.97 221.102 152.535 re W n q /GS0 gs 221.1023475 0 0 152.6830518 303.307086 100.8220009 cm /Im0 Do Q Q BT 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 0 Tw 9 0 0 9 303.3071 90.1701 Tm (\022\t\217\210\b\002\220 1.)Tj 0 0 0 1 k /GS1 gs /T1_3 1 Tf ( \210\027\034\021-\024\002\016\006\037 \f\034\022\024\021\037 \027\022\035\ \016\033\037\035\023\033\020\032\002 \022\024\035\034\005\020\022\021\034\ \036)Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 0 -1.2 TD [(F)-16(igure 1)47.1(.)]TJ 0 0 0 1 k /GS1 gs /T1_3 1 Tf [( Block diag)14.1(ram of)]TJ /Span<>> BDC ( )Tj EMC (literature search)Tj 1 0.68 0 0.12 k /GS0 gs /T1_5 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\007\003\032)50(\n\n\217\n)-21(\035\030\002)]TJ 53.418 0 Td [(MET)30(A)-41(-)-41.9(ANAL)30(Y)30(SIS)]TJ -53.418 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, 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Xֵ@LQ2LWTrY4xI.ظ'B;Guůw8wX>stream endstream endobj 1364 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\034\201\016\r\016\215\026\021\r\215\001\004 \017\021\020\016\f\215\001\004\ \b)-10(\026)11(\025\024\001: \021\t\016\025\b)-9.9(\026)10.9(\025\024\001, \017)10(\025\t\025\b)-10(\026)11(\025\024\001. \037)40.9(\001\017)10.1(\025\207 \r\001\201\021\001\215\026 )]TJ 0 -1 TD [(\235\016\213\025\222\001\b\215\016\016? \(\024\016\026)11(\001\001\215\001\t\021\213\022\021\022\b\021\b)-10(\026)11(\016\024\001\026\021\f\016\b\017\021\207 \025\235\213\025\201 \t\021\026\ )11(\016\201\001\026)-20(\200\201\220\))]TJ 41.159 1 Td [(Pr)31(e)11(v)12(entiv)12.1(e intestinal stoma: ileostom)21(y)31(, colostom)21(y)52(. )]TJ -4.661 -1 Td [(W)30(hich\022option\022is\022safer? \(meta-analy)10(sis and s)10(y)10(stematic r)31(e)11(vie)11(w\))]TJ ET 0 0 0 1 K 1 j 1 J [0 2.997]0 d /GS1 gs q 1 0 0 1 46.0167 276.5705 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 43.0197 276.5705 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q [0 2.997]0 d q 1 0 0 1 46.0167 239.3627 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 43.0197 239.3627 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q 0 j 0 J q 1 0 0 1 42.5197 185.2935 cm 0 0 m 453.543 0 l S Q BT /GS0 gs /T1_0 1 Tf 0.023 Tw 18 0 0 18 69.6076 723.8861 Tm [(Pr)31(e)11(v)12(entiv)12(e intestinal stoma: ileostom)21.1(y)31(, colostom)21(y)52(. W)30(hich )]TJ 0.415 -1.167 Td [(option is safer? \(meta-analy)10(sis and s)10(y)10(stematic r)31(e)11(vie)11(w\))]TJ 0 0 0 1 k /GS1 gs 14 0 0 14 42.5197 678.3822 Tm [(Y)40(ulia\022)-23.2(A)-31(.\022)-23.3(Elf)-21(imov)10(a, Rashid\022)-23.3(I.\022)-23.3(F)25(ay)21(z)10(ulin, Stanislav\022)-23.3(V)62(.\022)-23.3(Ch)11(erny)10(sh)11(ov)21.1(, )]TJ 0 Tw 0 -1.143 TD [(Ev)10(geny\022)-23.3(G.\022)-23.2(R)20(ybak)11(ov)]TJ 0.023 Tw 10 0 0 10 42.5197 644.713 Tm [(R)20(y)21(zhikh National Medical Resear)31(ch Center of\022)-23.3(Colopr)20.1(octology \(Saly)21(ama Adily)21.1(a\022)-23.3(st., 2, Moscow)22(, 1)125(23)58(423, Russia\))]TJ /T1_1 1 Tf -0.003 Tw 9 0 0 9 90.7087 626.209 Tm (AIM: to)Tj /Span<>> BDC ( )Tj EMC [(com)16(pare the)]TJ /Span<>> BDC ( )Tj EMC (incidence of)Tj /Span<>> BDC ( )Tj EMC [(early and late postoperativ)13.1(e com)16(plications af)-45.9(ter creation and closure of)]TJ /Span<>> BDC ( )Tj EMC [(p)46(rev)13(entiv)13(e )]TJ 0.074 Tw 0 -1.111 TD [(loop ileostom)11(y or colostom)11.1(y)42(, and to)]TJ /Span<>> BDC ( )Tj EMC [(deter)-14(mine whether one type of)]TJ /Span<>> BDC ( )Tj EMC (intestinal stoma is safer than the)Tj /Span<>> BDC ( )Tj EMC [(o)13(ther when )]TJ 0.023 Tw T* (creating a)Tj /Span<>> BDC ( )Tj EMC (low colorectal anastomosis.)Tj 0.105 Tw T* [(MA)45(TERIAL)-27.9(S A)53(ND METHODS: the)]TJ /Span<>> BDC ( )Tj EMC [(search for scientif)-43(ic papers w)13(as conducted in the)]TJ /Span<>> BDC ( )Tj EMC [(electronic d)26(atabases of)]TJ /Span<>> BDC ( )Tj EMC (medical )Tj 0.018 Tw T* [(literature PubMed and Elibrar)-43(y for the)]TJ /Span<>> BDC ( )Tj EMC (past 30 years using the)Tj /Span<>> BDC ( )Tj EMC [(k)17(eyw)12(ords: ileostom)11(y)42(, colostom)11(y)14(; loop ileostom)11(y)42(, loop )]TJ 0.002 Tw 0 -1.111 TD [(colostom)11.1(y)14(; tem)16(porar)-42.9(y stoma; com)16(plications. A)]TJ /Span<>> BDC ( )Tj EMC [(systematic revie)10.1(w and meta-analysis w)12(ere conducted, which included )]TJ 0.185 Tw 0 -1.111 TD [(5 randomized and 15 com)16(parativ)13.1(e non-randomized studies in Eng)13(lish and R)22(ussian, which ref)-22(lected the)]TJ /Span<>> BDC ( )Tj EMC (nature )Tj 0.065 Tw T* (of)Tj /Span<>> BDC ( )Tj EMC [(com)16(plications ar)-37(ising from the)]TJ /Span<>> BDC ( )Tj EMC (use and elimination of)Tj /Span<>> BDC ( )Tj EMC [(ileostomies and colostomies. Com)16(plications w)12(ere divided )]TJ 0.048 Tw T* (depending on the)Tj /Span<>> BDC ( )Tj EMC (nature and time of)Tj /Span<>> BDC ( )Tj EMC [(occur)-15.9(rence into early and late. Early com)16(plications included: stoma necrosis, )]TJ 0.082 Tw T* [(stoma bleeding, per)-37(istomal der)-13.9(matitis, stoma retraction, deh)12(y)14.1(dration and parastomal abscess. Late com)16(plications )]TJ 0.166 Tw T* [(included: stoma str)-37(icture, stoma p)46(rolapse, colorectal anastomo)13.1(tic failure and parastomal her)-14(nia. Com)16(plications )]TJ -0.023 Tw T* [(associated )0.6(with )0.5(reconstructiv)13.1(e )0.5(surg)12(er)-43(y )0.5(with )0.6(stoma )0.5(elimination )0.6(w)12(ere )0.5(also )0.6(analyzed: )0.5(postoperativ)13(e )0.5(her)-14(nia in the)]TJ /Span<>> BDC ( )Tj EMC 42.652 0 Td (stoma )Tj 0.022 Tw -42.652 -1.111 Td [(area, )0.6(w)12(ound )0.6(infection )0.6(and )0.6(hematoma )0.6(of)]TJ /Span<>> BDC ( )Tj EMC 15.92 0 Td [(the )0.6(anter)-37(ior )0.6(abdominal )0.7(w)13(all, )0.6(intestinal )0.5(obstruction. )0.6(The)]TJ /Span<>> BDC ( )Tj EMC 21.995 0 Td [(meta-analysis )0.6(w)13(as )]TJ 0.023 Tw -37.915 -1.111 Td [(per)-34(for)-13.9(med in accord)26.1(ance with the)]TJ /Span<>> BDC ( )Tj EMC [(p)46(ractice and P)66(RISMA recommend)26.1(ations.)]TJ 0.046 Tw 0 -1.111 TD [(RESUL)30(T)-10(S: when e)-15(x)10(amining com)16(parativ)13.1(e non-randomized studies, it w)13(as found that patients with colostom)11(y signif)-43(i)]TJ 0 Tw (-)Tj 0.067 Tw 0 -1.111 TD [(cantly more of)-46(ten dev)13(eloped late com)16(plications such as stoma str)-36.9(icture \(odds ratio \(OR\))]TJ /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC [(3.86; 95% Conf)-43(idence )]TJ 0.09 Tw 0 -1.111 TD [(inter)-41.9(v)15.9(al \(CI\): 1.27\22611.72; p)]TJ /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC [(0.02\) and stoma p)46(rolapse \(OR)]TJ /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (2.91; 95% CI: 1.49\2265.72; p)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC [(0.002\), as w)12(ell as )]TJ -0.006 Tw 0 -1.111 TD (an)Tj /Span<>> BDC ( )Tj EMC [(early com)16(plication in the)]TJ /Span<>> BDC ( )Tj EMC [(for)-13.9(m of)]TJ /Span<>> BDC ( )Tj EMC [(stoma retraction )0.5(\(OR)]TJ /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (2.53; 95% CI: 1.54\2264.16; p)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0.0002\). Whereas the)Tj /Span<>> BDC ( )Tj EMC (for)Tj 0 Tw 44.743 0 Td (-)Tj 0.036 Tw -44.743 -1.111 Td (mation of)Tj /Span<>> BDC ( )Tj EMC [(ileostom)11.1(y is associated with a)]TJ /Span<>> BDC ( )Tj EMC [(higher r)-37(isk of)]TJ /Span<>> BDC ( )Tj EMC [(deh)12(y)14(dration \(OR)]TJ /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0.23; 95% CI: 0.12\2260.45; p)Tj /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (0.00001\). )Tj 0.08 Tw 0 -1.111 TD (In contrast, in an)Tj /Span<>> BDC ( )Tj EMC (analysis of)Tj /Span<>> BDC ( )Tj EMC [(randomized clinical tr)-36.9(ials \(R)21(CT)58(s\), the)]TJ /Span<>> BDC ( )Tj EMC (incidence of)Tj /Span<>> BDC ( )Tj EMC [(com)16(plications such as stoma p)46(ro)]TJ 0 Tw (-)Tj 0.087 Tw T* (lapse \(OR)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (8.87; 95% CI: 2.53\22631.12; p)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC [(0.0007\) and deh)12(y)14(dration )0.5(\(OR)]TJ /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0.32; 95% CI: 0.03\2263.14; p)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0.33\) )Tj 0.031 Tw T* [(w)12(ere com)16.1(parable betw)12(een patients with colostom)11.1(y and ileostom)11.1(y)32(. Infor)-14(mation on stoma retraction w)13(as p)45.9(rovided in )]TJ 0.042 Tw T* [(only one R)21(CT)74(, while stoma str)-37(icture w)13(as no)13(t mentioned at all. In bo)13(th randomized \(OR)]TJ /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (1.19; 95% CI: 0.52\2262.75; )Tj 0.17 Tw T* (p)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC [(0.68\) and com)16(parativ)13.1(e non-randomized studies \(OR)]TJ /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0.56; 95% CI: 0.31\2261.02; p)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0.06\), the)Tj /Span<>> BDC ( )Tj EMC (incidence )Tj -0.01 Tw T* (of)Tj /Span<>> BDC ( )Tj EMC [(per)-37(istomal der)-14(matitis w)13(as slightly higher in patients with ileostom)11.1(y)41.9(, but statistical signif)-43(icance w)13(as no)13(t achiev)13(ed. )]TJ 0.044 Tw T* (The)Tj /Span<>> BDC ( )Tj EMC (incidence of)Tj /Span<>> BDC ( )Tj EMC [(stoma necrosis, stoma bleeding, parastomal abscess, and parastomal her)-14(nia did no)13(t dif)-40(fer in bo)13(th )]TJ -0.008 Tw 0 -1.111 TD [(g)14(roups. According to)]TJ /Span<>> BDC ( )Tj EMC [(the d)26(ata obtained, com)16.1(plications af)-45.9(ter reconstructiv)13.1(e surg)12(er)-37(ies associated with the)]TJ /Span<>> BDC ( )Tj EMC (elimination )Tj 0.023 Tw 0 -1.111 TD (of)Tj /Span<>> BDC ( )Tj EMC [(intestinal stoma are no)13(t typical for an)11(y of)]TJ /Span<>> BDC ( )Tj EMC [(the patient g)14(roups.)]TJ 0.083 Tw T* [(C)21(ON)22(CLUSION: the)]TJ /Span<>> BDC ( )Tj EMC (choice of)Tj /Span<>> BDC ( )Tj EMC (a)Tj /Span<>> BDC ( )Tj EMC [(p)46(rev)13(entiv)13(e stoma is still a)]TJ /Span<>> BDC ( )Tj EMC (subject of)Tj /Span<>> BDC ( )Tj EMC [(debate and discussion. Ileostom)11(y is associated )]TJ -0.008 Tw T* [(only )0.6(with )0.6(a)]TJ /Span<>> BDC ( )Tj EMC 4.521 0 Td [(higher )0.6(r)-37(isk )0.6(of)]TJ /Span<>> BDC ( )Tj EMC 5.39 0 Td [(deh)12(y)14(dration. )0.5(How)12.1(ev)13(er)61(, )0.5(the)]TJ /Span<>> BDC ( )Tj EMC 10.316 0 Td [(for)-14(mation )0.7(of)]TJ /Span<>> BDC ( )Tj EMC 5.142 0 Td (a)Tj /Span<>> BDC ( )Tj EMC 0.705 0 Td [(loop )0.6(colostom)11.1(y )0.5(is )0.6(accom)16(panied )0.5(by )0.6(a)]TJ /Span<>> BDC ( )Tj EMC 14.093 0 Td [(signif)-43(icantly )]TJ -0.004 Tw -40.168 -1.111 Td (higher incidence of)Tj /Span<>> BDC ( )Tj EMC [(p)46(rolapse, retraction and str)-36.9(icture of)]TJ /Span<>> BDC ( )Tj EMC [(the stoma, all o)13(ther com)16(plications w)12(ere com)16(parable. F)24(ur)-40(ther )]TJ 0.023 Tw T* [(randomized clinical tr)-37(ials are needed to)]TJ /Span<>> BDC ( )Tj EMC [(conf)-43(ir)-13.9(m the)]TJ /Span<>> BDC ( )Tj EMC (reliability of)Tj /Span<>> BDC ( )Tj EMC [(these dif)-39.9(ferences.)]TJ /T1_2 1 Tf 0.01 Tc -0.01 Tw 8 0 0 8 42.5596 300.9397 Tm [(KEYW)22(ORDS:)]TJ /T1_1 1 Tf 0 Tc 0.023 Tw 4.948 0 Td [( loop colostom)11(y)42(, loop ileostom)11.1(y)41.9(, early com)16(plications, and late com)16(plications)]TJ /T1_2 1 Tf 0.01 Tc 0.018 Tw -4.948 -1.909 Td [(C)19(ONFL)-33(ICT)5( OF)]TJ /Span<>> BDC 5.312 0 Td ( )Tj EMC [(INTE)25(REST)61.9(:)]TJ /T1_1 1 Tf 0 Tc 0.023 Tw 4.559 0 Td ( the)Tj /Span<>> BDC ( )Tj EMC [(authors declare no conf)-22(lict of)]TJ /Span<>> BDC ( )Tj EMC (interest)Tj /T1_2 1 Tf 0.012 Tc -0.047 Tw -9.871 -2.617 Td [(F)3.1(O)-4.7(R)8.6( )0.5(C)-17.6(I)-15.7(T)45.3(A)37.3(T)-24.6(I)-1.4(ON:)]TJ /T1_3 1 Tf -0.002 Tc -0.038 Tw 6.074 0 Td [( )0.5(E)-7.6(l)-22.5(f)-63.1(i)-3.3(m)-12.5(o)-10.4(v)-28.5(a)]TJ /Span<>> BDC ( )Tj EMC 3.981 0 Td [(Y)12.5(u)-9.1(.)-24(A)-23.1(.)-23.6(, )0.5(F)-6.6(a)-15(y)-34.1(z)-12.2(u)-8.5(l)-16.8(i)-3.3(n)]TJ /Span<>> BDC ( )Tj EMC 6.18 0 Td [(R)-21.5(.)-9.9(I)-10.4(.)-23.6(, )0.5(C)-16(h)-15.2(e)-12.2(r)-36(n)-15(y)-29.1(s)-8.9(h)-11(o)-10.4(v)]TJ /Span<>> BDC ( )Tj EMC 6.837 0 Td [(S)-9.7(.)40.5(V)39.6(.)-23.6(, )0.5(R)-30.4(y)-19.7(b)-17.8(a)-11.3(k)-3.9(o)-10.4(v)]TJ /Span<>> BDC ( )Tj EMC 5.474 0 Td [(E)-5.7(.)14.9(G)-11.7(. )0.5(P)-18.7(r)-19.2(e)-15.9(v)-18.8(e)-11.6(n)-17.4(t)-46.3(i)-14.6(v)-18.8(e )0.5(i)-3.3(n)-17.4(t)-24.8(e)-22.9(s)-29.4(t)-46.3(i)-3.4(n)-7.9(a)-11.5(l )0.6(s)-29.4(t)-22.1(o)-9.3(m)-8.4(a)-6.2(: )0.5(i)-7.2(l)-23.8(e)-21.1(o)-15.9(s)-29.4(t)-22(o)-9.3(m)-15.5(y)-6.2(, )0.5(c)-6.6(o)-15.7(l)-21(o)-16(s)-29.4(t)-22(o)-9.3(m)-15.5(y)18(. )0.5(W)-13.2(h)-14.1(i)-5.1(c)-10.3(h )0.5(o)-8.4(p)-22(t)-46.3(i)-6.9(o)-9.3(n)-2( )]TJ -0.006 Tc -0.049 Tw -28.551 -1.2 Td [(i)-7.3(s s)-24.6(a)-14.3(f)-28.5(e)-12(r)9.4(? \()41.8(m)-16.6(e)-22.2(t)-36.7(a)-19.5(-)-13.1(a)-7.5(n)-7.7(a)-11.3(l)-8.3(y)-28.8(s)-26(i)-7.3(s a)-7.5(n)-14.5(d s)-30.8(y)-28.8(s)-29.2(t)-24.6(e)-11.5(m)-8.2(a)-18.1(t)-46.1(i)-5(c r)-19.1(e)-15.7(v)-51.7(i)-10.9(e)-12.5(w)19.7(\))10.5(. )]TJ /T1_1 1 Tf 0.004 Tc -0.004 Tw [(K)14(ol)3.6(op)2.5(r)3.1(o)3.5(k)-19.1(t)2.3(ol)3.6(o)-3.2(g)-13.1(i)6.7(a)5.9(.)]TJ /T1_3 1 Tf -0.006 Tc -0.049 Tw 25.927 0 Td [( 2)-8.9(0)-3.7(2)-1.3(5)23.3(;)9.9(2)8.9(4)-13.5(\()40.2(4)30.4(\))14.5(:)21(1)1(5)4.8(2)9.8(\226)50.9(1)12.7(6)-10.8(6)5.1(. \()-0.8(i)-3.1(n R)-6.4(u)-21.9(s)-22.2(s)-15.4(.)43.3(\))10.4(. h)-17.1(t)-49.4(t)-29.3(p)-18.6(s)-7.9(:)1.9(/)84.8(/)36.5(d)-11(o)-12.5(i.)2.8(o)-11.7(r)-16.7(g)-22.7(/)11.3(1)14.1(0)6.5(.)-5.5(3)8(3)-15.9(8)1.4(7)4.7(8/)8(2)-8.8(0)9.4(7)-1.9(3)-13.2(-)41.3(7)10.7(5)0.5(5)-8.8(6)-26.7(-)9.8(2)-8.8(0)-3.8(2)-1.3(5)-23.4(-)]TJ -0.032 Tc 0.032 Tw -25.927 -1.2 Td [(2)-46.2(4)-83.5(-)-85.3(4)-83.5(-1)-54.1(5)-50.2(2)-43(-1)-42.4(6)-65.8(6)]TJ /T1_2 1 Tf 0.01 Tc 0.048 Tw 0.005 -2.617 Td [(\021\024\027\030\026)5( \024\033\023)5( \t\030\027\030\t\032\026\037\032:)]TJ /T1_1 1 Tf 0 Tc 0.053 Tw 10.637 0 Td ( \204\027\017\022\006\034\036\037 \234.\205., \216\223\210\215 \253\217\214\ \200\221 \021\034\027\034\f\033\034\021\035\034\027\034\013\022\022 \022\ \006\016\020\022 \205.\217.)Tj /Span<>> BDC ( )Tj EMC (\213\032\201\022\002\273 \214\022\020\031\b\033\037\036\037 \213\034\024\ \024\022\022, \023\027.)Tj /Span<>> BDC ( )Tj EMC (\207\037\027\030\006\037 \205\b\022\027\030, \b.)Tj /Span<>> BDC ( )Tj EMC (2, )Tj 0.023 Tw -10.642 -1.2 Td (\214\034\024\021\036\037, 123423, \213\034\024\024\022\030; e-mail: yuli\ a2209elfimova@gmail.com)Tj /T1_2 1 Tf 0.01 Tc 0.058 Tw 0.005 -1.2 Td [(ADDRESS)5( F)13(OR)5( C)19(ORRESPONDEN)23(CE:)]TJ /T1_1 1 Tf 0 Tc 0.063 Tw 14.13 0 Td [( )0.5(Elf)-43(imov)16(a )0.5(Y)39(u.A., Ryzhikh )0.5(N)18(ational )0.6(Medical )0.5(R)21(esearch )0.5(Center )0.5(of)]TJ /Span<>> BDC ( )Tj EMC [(Colop)46.1(roctology)42(, )0.5(Salyama )0.5(Adilya )0.5(st., )0.5(2, Moscow)52.1(, )]TJ 0.023 Tw -14.135 -1.2 Td [(123423, R)22(ussia; e-mail: yulia2209elf)-43(imov)16.1(a@gmail.com)]TJ 0 Tw 0 -2.792 TD (\n\037\035\037 \f\034\024\035\023\f\027\016\020\022\030)Tj /Span<>> BDC ( )Tj EMC (\227 30.06.2025)Tj /Span<>> BDC ( )Tj EMC 19.488 0 Td (\t\034\024\027\016 \b\034\033\037\025\034\035\021\022)Tj /Span<>> BDC ( )Tj EMC (\227 02.09.2025)Tj /Span<>> BDC ( )Tj EMC 18.78 0 Td (\t\033\022\020\030\035\034 \021)Tj /Span<>> BDC ( )Tj EMC (\f\023\025\027\022\021\037\007\022\022)Tj /Span<>> BDC ( )Tj EMC (\227 10.11.2025)Tj ( )Tj -38.268 -1.375 Td (Received)Tj /Span<>> BDC ( )Tj EMC (\227 30.06.2025)Tj /Span<>> BDC ( )Tj EMC 19.488 0 Td (Revised)Tj /Span<>> BDC ( )Tj EMC (\227 02.09.2025)Tj /Span<>> BDC ( )Tj EMC 18.78 0 Td (Accepted for publication)Tj /Span<>> BDC ( )Tj EMC (\227 10.11.2025)Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 42.5896 128.1078 Tm (\023\023\034\226\034\022\031\034)Tj 0 0 0 1 k /GS1 gs /T1_3 1 Tf 0 Tc 0.251 Tw 10 0 0 10 42.5197 103.7519 Tm (\210\007\027\017\n \017)Tj /Span<>> BDC ( )Tj EMC (\027\026\017\002\024\035\036\036 \020\030\024\027\t\b \024\f\035\024\032\ \027\036\027\017\005 \r)Tj /Span<>> BDC ( )Tj EMC (\b\017\030\031\030)Tj 0 Tw (-)Tj 0.115 Tw 0 -1.218 TD (\020\017\017 \030\026\022\026 \023\030\016\n\024\005 \022\017\001\022\017\ \016\r\035\016\036\021\f\016 \027\036\f\024\f\021\024\016\021\036\035\034\ \027\024\f\021\034 )Tj 0.226 Tw T* [(\026\027\026\f\021\024\n\024\026 )0.6(\(\203\202\), )0.5(\004\026\f\021\024\021\026 )0.5(\022\024\021\024\030\024\005 )0.6(\n\024\032\036\021 )0.5(\007\024\f\021\017\020\026\021\034 )]TJ 0.153 Tw 23.244 4.871 Td (24% [1\2264]. \215\030\017)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\n \f\031\013\036\f\021\r\031\036\021 \n\027\024\032\036\f\021\ \r\024 \235\026\022\021\024)Tj 0 Tw (-)Tj 0.156 Tw T* (\030\024\r, \r\035\017\016\033\013\017\b \027\026)Tj /Span<>> BDC ( )Tj EMC (\030\026\r\017\021\017\036 \203\202)Tj /Span<>> BDC ( )Tj EMC (\227 \024\021 \017\027\007\017\r\017\007\031\026\035\034)Tj 0 Tw (-)Tj 0.207 Tw T* (\027\t\b \024\f\024\002\036\027\027\024\f\021\036\005 \023\026\006\017\036\ \027\021\026 \007\024)Tj /Span<>> BDC ( )Tj EMC (\021\036\b\027\017\004\036\f\022\017\b \026\f\023\036\022)Tj 0 Tw (-)Tj 0.114 Tw T* (\021\024\r \024\023\036\030\026\021\017\r\027\024\020\024 \r\n\036\001\026\ \021\036\035\034\f\021\r\026, \021\026\022\017\b \022\026\022 \031\030\024\ \r\036\027\034 )Tj 0.377 Tw T* [(\023\036\030\036\f\036\004\036\027\017\016 \027\017\032\027\036\005 )0.5(\002\030\t\032\036\036\004\027\024\005 \026\030\021\036\030\017\017 \(\203\ \207\202\), )]TJ ET 1 0.68 0 0.12 k /GS0 gs q 1 0 0 1 42.5197 634.7129 cm 0 0 m 0 0 l 0 -11.339 l 42.52 -11.339 l 42.52 0 l h f Q BT 0 0 0 0 k /T1_2 1 Tf 0 Tw 9 0 0 9 45.2263 625.7856 Tm (ABSTRACT)Tj 1 0.68 0 0.12 k /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\007\003\032)50(\n\n\217\n)-21(\035\030\002)]TJ 53.418 0 Td [(MET)30(A)-41(-)-41.9(ANAL)30(Y)30(SIS)]TJ /T1_5 1 Tf 25 0 0 25 505.4271 56.0378 Tm (153)Tj ET endstream endobj 1361 0 obj [1371 0 R] endobj 1362 0 obj <>stream q /GS0 gs /Fm0 Do Q 0 0 0 1 K 1 j 1 J [0 2.997]0 d /GS1 gs q 1 0 0 1 74.3631 181.0103 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 71.3661 181.0103 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q [0 2.997]0 d q 1 0 0 1 74.3631 143.8024 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 71.3661 143.8024 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q BT 0 0 0 1 k /T1_0 1 Tf 10 0 0 10 70.8661 724.8299 Tm (https://doi.org/10.33878/2073-7556-2025-24-4-152-166)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0.023 Tw 19 0 0 19 126.3657 695.3259 Tm [(\034\201\016\r\016\215\026\021\r\215\001\004 \017\021\020\016\f\215\001\004\ \b)-9.9(\026)11(\025\024\001: \021\t\016\025\b)-10(\026)11(\025\024\001, )]TJ 0.685 -1.105 Td [(\017)10(\025\t\025\b)-10(\026)11(\025\024\001. \037)40.9(\001\017)10.1(\025\207 \r\001\201\021\001\215\026 \235\016\213\025\222\001\b\215\016\016\ ? )]TJ -2.414 -1.105 Td [(\(\024\016\026)11(\001\001\215\001\t\021\213\022)-23.2(\021\022)-23.3(\b\021\b)-10(\026)11(\016\024\001\026\021\f\016\b\017\021\207 \025\235\213\025\201 \t\021\026\ )11.1(\016\201\001\026)-20(\200\201\220\))]TJ 0 0 0 1 k /GS1 gs 14 0 0 14 70.8661 628.822 Tm [(\003\t\223\021\024\025\r\001\022)-23.2(\204.\n)-31(., \203\001\207\213)21(\200\t\021\215\022)-23.2(\033)124(.\030., \224\016\201\215\220\020\025\r\022)-23.2(\013.\006., \033\220\235\001\017)10(\025\r\022)-23.2(\003.\031)72(.)]TJ 10 0 0 10 70.8661 611.1527 Tm [(\203\031\206)42(\230 \253\217\007\030\226 \017)10(\025\t\025\222\201\025\017)-9.9(\026)11(\025\t\025\202\021\021 \021\024\016\215\021 \n)-30.9(.\217.\022)-23.3(\033\220\216\021\273 \007\021\215\213\211\201\001\r\001 \033\025\b\b\021\ \021 \(\200\t.\022)-23.2(\013\001\t\004\024\001 \n)-20.9(\211\021\t\004, \211.\022)-23.3(2, \202)62.1(.\022)-23.3(\007\025\b\017\r\001, )]TJ 0 -1.2 TD [(1)125(23)58(423, \033\025\b\b\021\004\))]TJ /T1_0 1 Tf 0.042 Tw 9 0 0 9 119.0551 580.6488 Tm [(\221\204\231\232: )0.5(\024\033\037\036\020\022\035\003 )0.6(\005\037\024\035\034\035\023 )0.6(\033\037\031\036\022\035\022\030 )0.6(\033\037\020\020\022\002 )0.5(\022)]TJ /Span<>> BDC ( )Tj EMC 19.142 0 Td [(\f\034\031\b\020\022\002 )0.5(\f\034\024\027\016\034\f\016\033\037\007\022\034\020\020\032\002 )0.5(\034\024\027\034\201\020\016\020\022\004 )0.6(\f\034\024\027\016 )0.5(\017\034\033\006\022\033\034\036\037\020\022\030 )]TJ 0.106 Tw -19.142 -1.111 Td (\022)Tj /Span<>> BDC ( )Tj EMC (\031\037\021\033\032\035\022\030 \f\033\016\036\016\020\035\022\036\020\032\ \002 \022\027\016\034\024\035\034\006 \022)Tj /Span<>> BDC ( )Tj EMC (\021\034\027\034\024\035\034\006, \037)Tj /Span<>> BDC ( )Tj EMC (\035\037\021\201\016 \034\f\033\016\b\016\027\022\035\003, \030\036\027\030\ \016\035\024\030 \027\022 \034\b\022\020 \035\022\f \021\022\001\016\005\ \020\034\004 )Tj 0.023 Tw 0 -1.111 TD (\024\035\034\006\032 \025\034\027\016\016 \025\016\031\034\f\037\024\020\ \032\006, \005\016\006 \b\033\023\013\034\004 \f\033\022)Tj /Span<>> BDC ( )Tj EMC (\017\034\033\006\022\033\034\036\037\020\022\022 \020\022\031\021\034\013\ \034 \021\034\027\034\033\016\021\035\037\027\003\020\034\013\034 \037\020\ \037\024\035\034\006\034\031\037.)Tj 0.086 Tw T* [(\214\205\202\204\213\200\205\231\233 )0.5(\200)]TJ /Span<>> BDC ( )Tj EMC [(\214\204\202\240\n\233: )0.6(\f\034\022\024\021 \020\037\023\005\020\032\002 )0.5(\033\037\025\034\035 )0.5(\f\033\034\036\034\b\022\027\024\030 )0.6(\036)]TJ /Span<>> BDC ( )Tj EMC [(\220\027\016\021\035\033\034\020\020\032\002 )0.5(\025\037\031\037\002 )0.5(\006\016\b\022\007\022\020\024\021\034\004 \027\022\035\016\033\037\035\023\ \033\032 )]TJ -0.037 Tw T* (PubMed \022)Tj /Span<>> BDC ( )Tj EMC (Elibrary \031\037)Tj /Span<>> BDC ( )Tj EMC (\f\034\024\027\016\b\020\022\016 30 \027\016\035 \f\034)Tj /Span<>> BDC ( )Tj EMC (\021\027\026\005\016\036\032\006 \024\027\034\036\037\006: ileostomy, co\ lostomy; loopileostomy, loopcolostomy; )Tj 0.036 Tw 0 -1.111 TD (temporary stoma; complications. \t\033\034\036\016\b\016\020 \024\022\024\ \035\016\006\037\035\022\005\016\024\021\022\004 \034\025\031\034\033 \022\ )Tj /Span<>> BDC ( )Tj EMC (\006\016\035\037\037\020\037\027\022\031, \036)Tj /Span<>> BDC ( )Tj EMC (\021\034\035\034\033\032\004 \025\032\027\034 \036\021\027\026\005\016\020\ \034 )Tj 0.154 Tw 0 -1.111 TD (5 \033\037\020\b\034\006\022\031\022\033\034\036\037\020\020\032\002 \022\ )Tj /Span<>> BDC ( )Tj EMC [(15 )0.5(\024\033\037\036\020\022\035\016\027\003\020\032\002 )0.5(\020\016\033\037\020\b\034\006\022\031\022\033\034\036\037\020\020\032\002\ )0.5(\022\024\024\027\016\b\034\036\037\020\022\004 \020\037)]TJ /Span<>> BDC ( )Tj EMC 35.819 0 Td (\037\020\013\027\022\004\024\021\034\006 \022)Tj /Span<>> BDC ( )Tj EMC (\033\023\024\024\021\034\006 )Tj -0.018 Tw -35.819 -1.111 Td (\030\031\032\021\037\002, \036)Tj /Span<>> BDC ( )Tj EMC (\021\034\035\034\033\032\002 \034\035\033\037\201\016\020 \002\037\033\037\ \021\035\016\033 \034\024\027\034\201\020\016\020\022\004, \036\034\031\020\ \022\021\037\026\235\022\002 \f\033\022)Tj /Span<>> BDC ( )Tj EMC (\022\024\f\034\027\003\031\034\036\037\020\022\022 \022)Tj /Span<>> BDC ( )Tj EMC (\027\022\021\036\022\b\037\007\022\022 \022\027\016\034\024\035\034\006 \ )Tj 0.02 Tw T* (\022)Tj /Span<>> BDC ( )Tj EMC 0.751 0 Td [(\021\034\027\034\024\035\034\006. )0.5(\240\024\027\034\201\020\016\020\022\030 )0.6(\025\032\027\022 )0.5(\033\037\031\b\016\027\016\020\032 )0.7(\036)]TJ /Span<>> BDC ( )Tj EMC 17.528 0 Td [(\031\037\036\022\024\022\006\034\024\035\022 )0.6(\034\035 )0.6(\002\037\033\037\021\035\016\033\037 )0.5(\022)]TJ /Span<>> BDC ( )Tj EMC 12.545 0 Td [(\036\033\016\006\016\020\022 )0.5(\036\034\031\020\022\021\020\034\036\016\020\022\030 )0.5(\020\037)]TJ /Span<>> BDC ( )Tj EMC 11.31 0 Td (\033\037\020\020\022\016 )Tj 0.071 Tw -42.134 -1.111 Td (\022)Tj /Span<>> BDC ( )Tj EMC (\f\034\031\b\020\022\016. \r)Tj /Span<>> BDC ( )Tj EMC (\033\037\020\020\022\006 \034\024\027\034\201\020\016\020\022\030\006 \034\ \035\020\016\024\027\022: \020\016\021\033\034\031 \024\035\034\006\032,\ \021\033\034\036\034\035\016\005\016\020\022\016 \022\031)Tj /Span<>> BDC ( )Tj EMC (\024\035\034\006\032, \f\016\033\022\024\035\034\006\037\027\003\020\032\ \004 \b\016\033)Tj 0 Tw (-)Tj 0.135 Tw T* (\006\037\035\022\035, \033\016\035\033\037\021\007\022\026 \024\035\034\006\ \032, \034\025\016\031\036\034\201\022\036\037\020\022\016 \022)Tj /Span<>> BDC ( )Tj EMC (\f\037\033\037\024\035\034\006\037\027\003\020\032\004 \037\025\024\007\016\ \024\024. \r)Tj /Span<>> BDC ( )Tj EMC (\f\034\031\b\020\022\006 \034\035\020\016\024\016\020\032: \024\035\033\022\ \021\035\023\033\037 )Tj 0.003 Tw 0 -1.111 TD [(\024\035\034\006\032, )0.5(\f\033\034\027\037\f\024 )0.5(\024\035\034\006\032, )0.5(\020\016\024\034\024\035\034\030\035\016\027\003\020\034\024\035\003 )0.6(\021\034\027\034\033\016\021\035\037\027\003\020\034\013\034 )0.5(\037\020\037\024\035\034\006\034\031\037 )0.5(\022)]TJ /Span<>> BDC ( )Tj EMC [(\f\037\033\037\024\035\034\006\037\027\003\020\037\030 )0.5(\013\033\032\201\037. \202\037\021\201\016 )]TJ 0.088 Tw 0 -1.111 TD (\025\032\027\022 \f\033\034\037\020\037\027\022\031\022\033\034\036\037\020\ \032 \034\024\027\034\201\020\016\020\022\030, \024\036\030\031\037\020\020\ \032\016 \024)Tj /Span<>> BDC ( )Tj EMC (\033\016\021\034\020\024\035\033\023\021\035\022\036\020\034-\036\034\024\ \024\035\037\020\034\036\022\035\016\027\003\020\034\004 \034\f\016\033\037\ \007\022\016\004 \024)Tj /Span<>> BDC ( )Tj EMC (\027\022\021)Tj 0 Tw (-)Tj 0.172 Tw T* (\036\022\b\037\007\022\016\004 \024\035\034\006\032: \f\034\024\027\016\034\ \f\016\033\037\007\022\034\020\020\037\030 \013\033\032\201\037 \036)Tj /Span<>> BDC ( )Tj EMC (\034\025\027\037\024\035\022 \024\035\034\006\032, \033\037\020\016\036\037\ \030 \022\020\017\016\021\007\022\030 \022)Tj /Span<>> BDC ( )Tj EMC (\013\016\006\037\035\034\006\037 \f\016\033\016\b\020\016\004 )Tj 0.062 Tw T* (\025\033\026\001\020\034\004 \024\035\016\020\021\022, \021\022\001\016\005\ \020\037\030 \020\016\f\033\034\002\034\b\022\006\034\024\035\003. \214\016\ \035\037\037\020\037\027\022\031 \036\032\f\034\027\020\016\020 \036)Tj /Span<>> BDC ( )Tj EMC (\024\034\034\035\036\016\035\024\035\036\022\022 \024)Tj /Span<>> BDC ( )Tj EMC (\f\033\037\021\035\022\021\034\004 \022)Tj /Span<>> BDC ( )Tj EMC (\033\016\021\034)Tj 0 Tw (-)Tj 0.023 Tw T* (\006\016\020\b\037\007\022\030\006\022 PRISMA.)Tj 0.006 Tw T* (\213\204\255\215\231\232\202\205\202\233: \f\033\022)Tj /Span<>> BDC ( )Tj EMC (\022\031\023\005\016\020\022\022 \024\033\037\036\020\022\035\016\027\003\ \020\032\002 \020\016\033\037\020\b\034\006\022\031\022\033\034\036\037\020\ \020\032\002 \022\024\024\027\016\b\034\036\037\020\022\004 \036\032\030\ \036\027\016\020\034, \005\035\034 \023)Tj /Span<>> BDC ( )Tj EMC (\f\037\007\022\016\020\035\034\036 )Tj 0.139 Tw T* (\024)Tj /Span<>> BDC ( )Tj EMC (\021\034\027\034\024\035\034\006\034\004 \024\023\235\016\024\035\036\016\ \020\020\034 \005\037\235\016 \033\037\031\036\022\036\037\027\022\024\003\ \f\034\031\b\020\022\016 \034\024\027\034\201\020\016\020\022\030 \035\037\ \021\022\016, \021\037\021 \024\035\033\022\021\035\023\033\037 \024\035\ \034\006\032 \(\034\035\020\034)Tj 0 Tw (-)Tj 0.126 Tw T* (\001\016\020\022\016 \001\037\020\024\034\036 \(\240\245\))Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (3,86; 95% \n\034\036\016\033\022\035\016\027\003\020\032\004 \022\020\035\ \016\033\036\037\027 \(\n\200\): 1,27\22611,72; \033)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,02\) \022)Tj /Span<>> BDC ( )Tj EMC (\f\033\034\027\037\f\024 \024\035\034\006\032 )Tj 0.004 Tw T* (\(\240\245)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (2,91; 95% \n\200: 1,49\2265,72; \033)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,002\), \037)Tj /Span<>> BDC ( )Tj EMC (\035\037\021\201\016 \033\037\020\020\016\016 \034\024\027\034\201\020\016\ \020\022\016 \036)Tj /Span<>> BDC ( )Tj EMC (\036\022\b\016 \033\016\035\033\037\021\007\022\022 \024\035\034\006\032\ \(\240\245)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (2,53; )Tj 0.023 Tw 0 -1.111 TD (95% \n\200: 1,54\2264,16; \033)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,0002\). \202\034\013\b\037 \021\037\021 \017\034\033\006\022\033\034\036\ \037\020\022\016 \022\027\016\034\024\035\034\006\032 \024\036\030\031\037\ \020\034 \024)Tj /Span<>> BDC ( )Tj EMC (\025\034\027\016\016 \036\032\024\034\021\022\006 \033\022\024\021\034\006\ \033\037\031\036\022)Tj 0 Tw (-)Tj -0.03 Tw 0 -1.111 TD [(\035\022\030 )0.5(\034\025\016\031\036\034\201\022\036\037\020\022\030 )0.7(\(\240\245)]TJ /Span<>> BDC ( )Tj EMC 10.41 0 Td (=)Tj /Span<>> BDC ( )Tj EMC 0.702 0 Td [(0,23; )0.5(95% )0.5(\n\200: )0.6(0,12\2260,45; )0.5(\033)]TJ /Span<>> BDC ( )Tj EMC 10.954 0 Td (<)Tj /Span<>> BDC ( )Tj EMC 0.702 0 Td [(0,00001\). )0.5(\217\037\f\033\034\035\022\036, )0.5(\f\033\022)]TJ /Span<>> BDC ( )Tj EMC 10.415 0 Td [(\037\020\037\027\022\031\016 )0.5(\033\037\020\b\034\006\022\031\022\033\034\036\037\020\020\032\002 )]TJ -0.02 Tw -33.185 -1.111 Td [(\021\027\022\020\022\005\016\024\021\022\002 )0.6(\022\024\024\027\016\b\034\036\037\020\022\004 )0.5(\(\213\r\200\) )0.6(\005\037\024\035\034\035\037 )0.6(\033\037\031\036\022\035\022\030 )0.6(\035\037\021\022\002 )0.6(\034\024\027\034\201\020\016\020\022\004, )0.5(\021\037\021 )0.6(\f\033\034\027\037\f\024 )0.5(\024\035\034\006\032 )0.5(\(\240\245)]TJ /Span<>> BDC ( )Tj EMC 40.355 0 Td (=)Tj /Span<>> BDC ( )Tj EMC 0.712 0 Td [(8,87; )0.6(95% )]TJ 0.081 Tw -41.068 -1.111 Td (\n\200: 2,53\22631,12; \033)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,0007\) \022)Tj /Span<>> BDC ( )Tj EMC (\034\025\016\031\036\034\201\022\036\037\020\022\016 \(\240\245)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,32; 95% \n\200: 0,03\2263,14; \033)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,33\) \025\032\027\022 \024\034\f\034\024\035\037\036\022\006\032 )Tj -0.004 Tw T* (\006\016\201\b\023 \f\037\007\022\016\020\035\037\006\022 \024)Tj /Span<>> BDC ( )Tj EMC (\021\034\027\034\024\035\034\006\034\004 \022)Tj /Span<>> BDC ( )Tj EMC (\022\027\016\034\024\035\034\006\034\004. \200\020\017\034\033\006\037\007\ \022\030 \034)Tj /Span<>> BDC ( )Tj EMC (\033\016\035\033\037\021\007\022\022 \024\035\034\006\032 \025\032\027\037\ \f\033\016\b\024\035\037\036\027\016\020\037 \027\022\001\003 )Tj -0.005 Tw T* (\036)Tj /Span<>> BDC ( )Tj EMC (\034\b\020\034\006 \213\r\200, \036)Tj /Span<>> BDC ( )Tj EMC (\035\034 \036\033\016\006\030 \021\037\021 \024\035\033\022\021\035\023\033\ \037 \024\035\034\006\032 \036\034\036\024\016 \020\016 \023\f\034\006\022\ \020\037\027\037\024\003. \r\037\021 \036)Tj /Span<>> BDC ( )Tj EMC (\033\037\020\b\034\006\022\031\022\033\034\036\037\020\020\032\002 \(\240\ \245)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (1,19; )Tj 0.023 Tw T* (95% \n\200: 0,52\2262,75; \033)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,68\), \035\037\021 \022)Tj /Span<>> BDC ( )Tj EMC (\036 \024\033\037\036\020\022\035\016\027\003\020\032\002 \020\016\033\037\ \020\b\034\006\022\031\022\033\034\036\037\020\020\032\002 \022\024\024\027\ \016\b\034\036\037\020\022\030\002 \(\240\245)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,56; 95% )Tj -0.024 Tw T* (\n\200: 0,31\2261,02; p)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,06\) \005\037\024\035\034\035\037 \033\037\031\036\022\035\022\030 \f\016\ \033\022\024\035\034\006\037\027\003\020\034\013\034 \b\016\033\006\037\035\ \022\035\037 \025\032\027\037 \020\016\024\021\034\027\003\021\034 \036\032\ \001\016 \023)Tj /Span<>> BDC ( )Tj EMC (\f\037\007\022\016\020\035\034\036 )Tj 0.079 Tw T* (\024)Tj /Span<>> BDC ( )Tj EMC [(\022\027\016\034\024\035\034\006\034\004, )0.5(\034\b\020\037\021\034 )0.5(\023\033\034\036\020\030 \024\035\037\035\022\024\035\022\005\016\024\021\ \034\004 )0.5(\031\020\037\005\022\006\034\024\035\022 )0.6(\020\016 \034\035\006\016\005\016\020\034. \211\037\024\035\034\035\037 \ \020\016\021\033\034\031\037 )0.5(\024\035\034\006\032, \021\033\034\036\034)]TJ 0 Tw (-)Tj 0.126 Tw 0 -1.111 TD (\035\016\005\016\020\022\030 \022\031)Tj /Span<>> BDC ( )Tj EMC (\024\035\034\006\032, \f\037\033\037\024\035\034\006\037\027\003\020\034\ \013\034 \037\025\024\007\016\024\024\037, \037)Tj /Span<>> BDC ( )Tj EMC (\035\037\021\201\016 \f\037\033\037\024\035\034\006\037\027\003\020\034\004\ \013\033\032\201\022 \020\016 \033\037\031\027\022\005\037\026\035\024\030\ \036)Tj /Span<>> BDC ( )Tj EMC (\034\025\016\022\002 )Tj 0.039 Tw 0 -1.111 TD (\013\033\023\f\f\037\002. \207\034\013\027\037\024\020\034 \f\034\027\023\ \005\016\020\020\032\006 \b\037\020\020\032\006, \034\024\027\034\201\020\ \016\020\022\030 \f\034\024\027\016 \033\016\021\034\020\024\035\033\023\ \021\035\022\036\020\034-\036\034\024\024\035\037\020\034\036\022\035\016\ \027\003\020\032\002 \034\f\016\033\037\007\022\004, )Tj 0.023 Tw T* (\024\036\030\031\037\020\020\032\002 \024)Tj /Span<>> BDC ( )Tj EMC (\027\022\021\036\022\b\037\007\022\016\004 \021\022\001\016\005\020\034\004\ \024\035\034\006\032, \020\016 \002\037\033\037\021\035\016\033\020\032\ \020\022 \b\027\030 \034\b\020\034\004 \022\031)Tj /Span<>> BDC ( )Tj EMC (\013\033\023\f\f \f\037\007\022\016\020\035\034\036.)Tj 0.099 Tw T* (\255\205\r\231\234\211\204\217\200\204: \036\034\f\033\034\024 \036\032\025\ \034\033\037 \f\033\016\036\016\020\035\022\036\020\034\004 \024\035\034\ \006\032 \f\034-\f\033\016\201\020\016\006\023 \034\024\035\037\016\035\024\ \030 \f\033\016\b\006\016\035\034\006 \034\025\024\023\201\b\016\020\022\ \004 \022)Tj /Span<>> BDC ( )Tj EMC (\b\022\024)Tj 0 Tw (-)Tj 0.16 Tw T* (\021\023\024\024\022\004. \200\027\016\034\024\035\034\006\037 \024\036\030\ \031\037\020\037 \027\022\001\003 \024)Tj /Span<>> BDC ( )Tj EMC (\025\034\027\016\016 \036\032\024\034\021\022\006 \033\022\024\021\034\006\ \036\034\031\020\022\021\020\034\036\016\020\022\030 \034\025\016\031\036\ \034\201\022\036\037\020\022\030. \006\016\024\035\016 \024)Tj /Span<>> BDC ( )Tj EMC (\035\016\006, )Tj 0.018 Tw T* (\017\034\033\006\022\033\034\036\037\020\022\016 \f\016\035\027\016\036\034\ \004 \021\034\027\034\024\035\034\006\032 \024\034\f\033\034\036\034\201\ \b\037\016\035\024\030 \024\023\235\016\024\035\036\016\020\020\034 \025\ \034\027\003\001\016\004 \005\037\024\035\034\035\034\004 \033\037\031\036\ \022\035\022\030 \f\033\034\027\037\f\024\037, )Tj 0.082 Tw T* [(\033\016\035\033\037\021\007\022\022 )0.6(\022)]TJ /Span<>> BDC ( )Tj EMC [(\024\035\033\022\021\035\023\033\032 )0.6(\024\035\034\006\032, )0.6(\036\024\016 )0.5(\034\024\035\037\027\003\020\032\016 )0.6(\034\024\027\034\201\020\016\020\022\030 )0.5(\034\021\037\031\037\027\022\024\003 )0.5(\024\034\f\034\024\035\037\036\022\006\032. )0.5(\n\027\030 \f\034\b\035\036\016\033\201\b\016\020\022\030 )]TJ 0.023 Tw 0 -1.111 TD (\b\034\024\035\034\036\016\033\020\034\024\035\022 \220\035\022\002 \033\ \037\031\027\022\005\022\004 \020\016\034\025\002\034\b\022\006\032 \b\037\ \027\003\020\016\004\001\022\016 \033\037\020\b\034\006\022\031\022\033\034\ \036\037\020\020\032\016 \021\027\022\020\022\005\016\024\021\022\016 \022\ \024\024\027\016\b\034\036\037\020\022\030.)Tj /T1_2 1 Tf 0.01 Tc 0.018 Tw 8 0 0 8 70.9061 205.3795 Tm [(\037\033\016\r\030\025\f\030)5( \026\033\036\025\021:)]TJ /T1_0 1 Tf 0 Tc 0.023 Tw 8.493 0 Td ( \f\033\016\036\016\020\035\022\036\020\037\030 \021\034\027\034\024\035\ \034\006\037, \f\033\016\036\016\020\035\022\036\020\037\030 \022\027\016\ \034\024\035\034\006\037, \033\037\020\020\022\016 \034\024\027\034\201\020\ \016\020\022\030, \f\034\031\b\020\022\016 \034\024\027\034\201\020\016\020\ \022\030)Tj /T1_2 1 Tf 0.01 Tc 0.018 Tw -8.493 -1.909 Td [(\037\036\035\034\033\032\037\031)5( \032\035\031\030\027\030\026\036\025:)]TJ /T1_0 1 Tf 0 Tc 0.023 Tw 10.401 0 Td ( \037\036\035\034\033\032 \031\037\030\036\027\030\026\035 \034\025 \034\ \035\024\023\035\024\035\036\022\022 \021\034\020\017\027\022\021\035\037\ \022\020\035\016\033\016\024\034\036)Tj /T1_2 1 Tf 0.033 Tc 0.158 Tw -10.401 -2.617 Td [(\024\033\023)4.7( \022\032\031\032\027\036\025\021\035\032\023:)]TJ /T1_3 1 Tf 0.023 Tc 0.163 Tw 9.331 0 Td ( \213\035\235\017\n\024\r\026)Tj /Span<>> BDC ( )Tj EMC (\222.\202., \205\026\005\031\035\017\027)Tj /Span<>> BDC ( )Tj EMC (\217.\236., \232\036\030\027\t\001\024\r)Tj /Span<>> BDC ( )Tj EMC (\224.\200., \217\t\002\026\022\024\r)Tj /Span<>> BDC ( )Tj EMC [(\213.\206. \215\030\036\r\036\027\021\017\r\027\026\016 \022\017\001\036\ \004\027\026\016 \f\021\024\n\026: \017\035\036\024\f\021\024\n\026,)23( )]TJ 0.082 Tw -9.336 -1.2 Td [(\022\024\035\024\f\021\024\n\026. )0.5(\025\026\022\024\005 )0.5(\r\026\030\017\026\027\021 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K)0.7(h)6.2(r)-40.2(y)3.8(u)4.6(k)-18.5(i)8.4(n)-6(, )]TJ 0 Tw T* [(A)3.6(l)4.8(ek)-17.5(s)7.8(a)-0.8(n)-0.6(d)5.3(r)]TJ /Span<>> BDC ( )Tj EMC [(Y)33.7(u)7.7(. T)-2.7(i)0.9(t)1.5(o)-0.6(v)]TJ /T1_0 1 Tf 1.563 Tw T* [(C)-6.5(o)-5.8(l)-19(l)-14.3(e)-9.4(c)-32.5(t)-37.3(i)3.2(o)0.8(n a)2.4(n)-4.6(d p)-3.8(r)-6(o)-7(ce)-13.3(s)-12.8(s)-16.6(i)7.1(n)-1.8(g o)-2.2(f)]TJ /Span<>> BDC ( )Tj EMC [(m)1.8(a)-8.4(t)-15.2(e)-2.1(r)-48(i)5.1(a)-1.5(l)-44.6(s)2.3(:)]TJ /T1_2 1 Tf 0 Tw ( )Tj -0.049 Tw T* [(A)3.8(n)4.8(a)-3(s)-10.7(t)2.3(a)-3(s)-8.2(i)5.9(a)]TJ /Span<>> BDC ( )Tj EMC 4.005 0 Td [(S)2.1(.)]TJ /Span<>> BDC ( )Tj EMC 0.94 0 Td [(B)6(r)7.7(a)-0.8(g)-14.5(i)8.4(n)4.8(a)-13.9(, )0.5(R)7.2(om)4.3(a)-0.8(n)]TJ /Span<>> BDC ( )Tj EMC 6.31 0 Td [(Y)33.7(u)7.7(. )0.5(K)0.7(h)6.2(r)-40.2(y)3.8(u)4.7(k)-18.5(i)8.4(n)-6(, )0.5(I)14(v)10.8(a)-0.8(n)]TJ /Span<>> BDC ( )Tj EMC 7.151 0 Td [(S)2.1(.)]TJ /Span<>> BDC ( )Tj EMC 0.94 0 Td [(A)3.8(n)1.9(o)3.3(s)4.9(o)-0.6(v)]TJ /T1_0 1 Tf -0.007 Tc 0.007 Tw -19.347 -1.218 Td [(St)-34.7(a)-15.4(t)-44.4(i)-4.3(s)-27(t)-44.4(i)-1.8(c)-18.8(a)-8.5(l)-7( p)-10.8(r)-13(o)-13.9(c)-6.9(e)-20.2(s)-19.8(s)-23.6(in)-8.9(g)2(:)]TJ /T1_2 1 Tf 0 Tc 0 Tw 9.088 0 Td [( R)7.2(om)4.3(a)-0.7(n)]TJ /Span<>> BDC ( )Tj EMC [(Y)33.7(u)7.7(. K)0.7(h)6.2(r)-40.2(y)3.8(u)4.6(k)-18.4(i)8.4(n)]TJ /T1_0 1 Tf -0.052 Tc 0.06 Tw -9.088 -1.218 Td [(Te)-75.9(x)-88(t)-52( w)-73(r)-100(i)-58(t)-89.4(i)-44.8(n)-53.9(g)-43.1(:)]TJ /T1_2 1 Tf 0 Tc 0.008 Tw 5.241 0 Td [( A)3.8(n)4.8(a)-3(s)-10.7(t)2.3(a)-3(s)-8.3(i)6(a)]TJ /Span<>> BDC ( )Tj EMC [(S)2.1(.)]TJ /Span<>> BDC ( )Tj EMC [(B)6(r)7.7(a)-0.8(g)-14.5(i)8.4(n)4.8(a)-14(, R)7.2(om)4.4(a)-0.8(n)]TJ /Span<>> BDC ( )Tj EMC [(Y)33.7(u)7.7(. K)0.7(h)6.2(r)-40.2(y)3.8(u)4.6(k)-18.5(i)8.4(n)-6(, )]TJ -0.002 Tc 0.002 Tw -5.241 -1.218 Td [(I)12(v)8.8(a)-2.8(n)]TJ /Span<>> BDC 1.701 0 Td ( )Tj EMC (S.)Tj /Span<>> BDC 0.99 0 Td ( )Tj EMC [(A)1.8(no)1.3(s)2.9(o)-2.5(v)]TJ /T1_0 1 Tf 0.006 Tc -0.006 Tw -2.691 -1.218 Td [(E)11.6(dit)-31.4(i)13.1(n)4.1(g)15(:)]TJ /T1_2 1 Tf 0 Tc 0 Tw 3.238 0 Td [( A)3.6(l)4.8(ek)-17.4(s)7.8(a)-0.8(n)-0.6(d)5.2(r)]TJ /Span<>> BDC ( )Tj EMC [(Y)33.7(u)7.7(. T)-2.6(i)0.9(t)1.4(o)-0.6(v)]TJ /T1_1 1 Tf 0.023 Tw 20.007 28.009 Td (\255\026\036\031\036\025\034\226 \017\223 \032\026\020\017\022\032\225 \(\ ORCID\))Tj /T1_0 1 Tf -0.003 Tw T* (\207\030\026\020\017\027\026 \202\027\026\f\021\026\f\017\016 \224\036\030\ \020\036\036\r\027\026)Tj /Span<>> BDC ( )Tj EMC (\227 \r\030\026\004-\022\024\035\024\023\030\024\022\021\024\035\024\020\ )Tj 0.483 Tw T* (\023\024\035\017\022\035\017\027\017\022\017 \210\002\035\026\f\021\027\024\ \020\024 \020\026\f\021\030\024\220\027\021\036\030\024\035\024\020\017\004\ \036\f\022\024\020\024 )Tj 0.01 Tw T* (\006\036\027\021\030\026 \207\211\003 \200\210 \253\200\024\030\024\027\036\ \032\f\022\026\016 \024\002\035\026\f\021\027\026\016 \022\035\017\027\017\ \004\036\f\022\026\016 )Tj 0 Tw T* (\002\024\035\034\027\017\006\026 \2231\273; ORCID 0009-0005-0471-4531)Tj 0.117 Tw T* [(\216\030\033\022\017\027 )0.5(\217\024\n\026\027 \222\030\034\036\r\017\004)]TJ /Span<>> BDC ( )Tj EMC 10.424 0 Td [(\227 \022.\n.\027., )0.5(\f\021\026\030\001\017\005 \027\026\031\004\027\t\005 )]TJ 0.745 Tw -10.424 -1.218 Td (\f\024\021\030\031\007\027\017\022 \024\021\007\036\035\026 \n\026\035\024\ \017\027\r\026\017\r\027\024\005 \023\030\024\022\021\024\035\024\020\017\ \017 )Tj 0.221 Tw T* (\205\206\207\211 \253\203\204\236\037 \022\024\035\024\023\030\024\022\021\ \024\035\024\020\017\017 \017\n\036\027\017 \202.\203. \217\t\032\017\b\273\ )Tj 0 Tw T* (\204\017\027\007\030\026\r\026 \217\024\f\f\017\017; ORCID 0000-0003-05\ 56-1782)Tj 0.082 Tw T* (\202\027\024\f\024\r \236\r\026\027 \224\036\030\020\036\036\r\017\004)Tj /Span<>> BDC ( )Tj EMC (\227 \022.\n.\027., \026\r\036\007\031\033\013\017\005 \024\021\007\036\ )Tj 0 Tw (-)Tj -0.029 Tw T* (\035\024\n \n\026\035\024\017\027\r\026\017\r\027\024\005 \023\030\024\022\ \021\024\035\024\020\017\017 \205\206\207\211 \253\203\204\236\037 \022\024\ \035\024)Tj 0 Tw (-)Tj 0.08 Tw T* (\023\030\024\022\021\024\035\024\020\017\017 \017\n\036\027\017 \202.\203\ . \217\t\032\017\b\273 \204\017\027\007\030\026\r\026 \217\024\f\f\017\017\ ; )Tj 0 Tw 0 -1.218 TD (ORCID 0000-0002-9015-2600)Tj 0.171 Tw 0 -1.218 TD (\230\017\021\024\r \202\035\036\022\f\026\027\007\030 \222\030\034\036\r\ \017\004)Tj /Span<>> BDC ( )Tj EMC (\227 \007.\n.\027., \020\035\026\r\027\t\005 \027\026\031\004)Tj 0 Tw (-)Tj 0.238 Tw 0 -1.218 TD (\027\t\005 \f\024\021\030\031\007\027\017\022 \024\021\007\036\035\036\027\ \017\016 \024\002\013\036\005 \017)Tj /Span<>> BDC ( )Tj EMC (\030\036\022\024\027\f\021\030\031\022\021\017\r)Tj 0 Tw (-)Tj 0.058 Tw T* [(\027\024\005 \022\024\035\024\023\030\024\022\021\024\035\024\020\017\017\ \203\204\236\037 )0.5(\022\024\035\024\023\030\024\022\021\024\035\024\020\017\017 \017\n\036\027\ \017 )]TJ 0 Tw T* (\202.\203.)Tj /Span<>> BDC ( )Tj EMC (\217\t\032\017\b; ORCID 0000-0002-1636-8075)Tj /T1_1 1 Tf 0.023 Tw 0 -2.436 TD (INFORMATION ABOUT THE)Tj /Span<>> BDC ( )Tj EMC (AUTHORS \(ORCID\))Tj /T1_0 1 Tf 0 Tw 0 -1.218 TD [(Anast)15(asia S. Br)-32.9(a)-17(gina)]TJ /Span<>> BDC ( )Tj EMC (\227 0009-0005-0471-4531)Tj T* [(R)11(oman Y)35(u. Khr)-23.9(yuk)-16(in)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0003-0556-1782)Tj T* [(Iv)-15(an S. Anosov)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0002-9015-2600)Tj T* [(Alek)-10(sandr Y)35.1(u. T)35(i)-24(t)17(ov)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0002-1636-8075)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 70.936 408.2019 Tm [(\r\031\024\034\033)48(\026)45(\024)-10(\223\033)48(\026/REFERENSES)]TJ 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0 Tc 0.237 Tw 8 0 0 8 70.8661 395.3672 Tm (1.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (\202\f\f\024\006\017\026\006\017\016 \022\024\035\024\023\030\024\022\021\ \024\035\024\020\024\r \217\024\f\f\017\017. \025\035\017\027\017\004\036\ \f\022\017\036 \030\036\022\024\n\036\027)Tj 0 Tw (-)Tj 0.151 Tw -1.296 -1.25 Td [(\007\026\006\017\017 \253\225\023\017\021\036\035\017\026\035\034\027\t\005\ \022\024\023\004\017\022\024\r\t\005 \b\024\007\273 2021. URL: ht)-30(tps://akr-)]TJ 0.009 Tc 0.349 Tw 0 -1.25 TD [(o)0.5(nl)-30.5(i)0.5(n)0.5(e.)0.5(r)-21.5(u)0.5(/u)0.5(p)0.5(l)30.5(oa)0.5(d/)0.5(i)0.5(b)0.5(l)30.4(o)-15.5(c)0.5(k/)0.5(4)0.5(bd)0.5(/)0.5(\025)0.5(\217%)0.5(2)0.5(0\225)0.5(\025)0.5(\216)0.5(%2)0.5(0)0.5(L)0.5(05)0.5(.)0.5(O%)0.5(2)0.5(0L)0.5(0)0.5(5.)0.5(9)0.5(.)0.5(pd)0.5(f)0.5( /)]TJ 0 Tc 0.133 Tw T* [(Russian Asso)-16(c)-24(ia)15(t)-32(ion of)]TJ /Span<>> BDC ( )Tj EMC [(col)30(op)25(r)-32(o)-16(c)-15.9(t)17(ol)30(o)-16(g)16(y. Cl)-31(inical P)35(r)-33(a)-17(c)-16(t)-31.9(ice Guidel)-31(ines )]TJ 0.112 Tw T* [(\253P)-24(il)30(onid)42.1(al sinus disease\273 2021. URL: ht)-30(tps://akr-onl)-30.9(ine.r)-21.9(u/upl)30(oad/)]TJ 0.023 Tw T* [(ibl)30(o)-16(ck/4bd/\025\217%20\225\025\216%20L05.O%20L05.9.pdf . \(In Russ.\))]TJ 0.17 Tw T* (2.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (Bi)Tj /Span<>> BDC ( )Tj EMC (S, Sun)Tj /Span<>> BDC ( )Tj EMC (K, Chen)Tj /Span<>> BDC ( )Tj EMC [(S, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Sur)-32(gical p)25(r)-32(o)-16(cedur)-23.9(es in t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(pil)30.1(onid)42(al )]TJ 0.158 Tw -1.296 -1.25 Td [(sinus )0.5(disease: )0.5(a)]TJ /Span<>> BDC ( )Tj EMC 6.979 0 Td [(sy)-13(stema)15.1(t)-32(ic r)-23.9(ev)-16(iew )0.5(and )0.5(ne)-12(t)-32(w)-14(or)-24(k )0.5(me)-12(t)15.1(a-anal)35(y)-13(sis. )]TJ /T1_2 1 Tf 0 Tw 19.544 0 Td (Sci )Tj -0.021 Tc 0.021 Tw -26.523 -1.25 Td [(Re)-21(p)]TJ /T1_0 1 Tf 0 Tc 0.023 Tw 1.418 0 Td [(.2020;10\(1\):13720. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1038/s41598-020-70641-7)Tj 0 0 0 1 k /GS1 gs 0.081 Tw -1.418 -1.25 Td (3.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(M)-24(ohamadi)]TJ /Span<>> BDC ( )Tj EMC [(S, N)-14(or)-32(o)-16(oznezhad)]TJ /Span<>> BDC ( )Tj EMC [(A)58.1(H, M)-24(ost)15(af)16(aei)]TJ /Span<>> BDC ( )Tj EMC [(S, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC (al. A)Tj /Span<>> BDC ( )Tj EMC [(r)-33(and)-16(omized )]TJ -0.012 Tw -1.296 -1.25 Td [(contr)-32(olled tr)-37(ial of)]TJ /Span<>> BDC ( )Tj EMC [(ef)-56(fec)-16(t)-32(i)-16(veness of)]TJ /Span<>> BDC ( )Tj EMC [(pl)-16(a)15(tele)-12(t-r)-36.9(ich pl)-15.9(as)26(ma gel and r)-24(egu)]TJ 0 Tw (-)Tj 0.086 Tw T* [(l)-16(ar dr)-24(essing on w)-13.9(ound heal)-30.9(ing t)-32(ime in pil)30(onid)42(al sinus sur)-32(ger)-23.9(y: R)11(ole )]TJ 0.133 Tw T* (of)Tj /Span<>> BDC ( )Tj EMC [(dif)-55.9(fer)-24(ent af)-55.9(fec)-16(t)-32(ing f)16(a)-17(c)-16(t)17(or)-10(s. )]TJ /T1_2 1 Tf (Biomed)Tj /Span<>> BDC ( )Tj EMC (J)Tj /T1_0 1 Tf (. 2019 Dec;42\(6\):403\226410. )Tj 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1016/j.bj.2019.05.002)Tj 0 0 0 1 k /GS1 gs 0.023 Tw ( Epub 2019 Dec 10.)Tj 0.085 Tw -1.847 -1.25 Td (4.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Spyr)-37(id)42(ak)-15.9(is)]TJ /Span<>> BDC ( )Tj EMC [(M, Chr)-37(ist)17(od)-16(oul)-30.9(idis)]TJ /Span<>> BDC ( )Tj EMC [(G, Cha)15(tzi)-24(t)-12.9(heof)-28(il)30(ou)]TJ /Span<>> BDC ( )Tj EMC [(C, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. T)47(he)]TJ /Span<>> BDC ( )Tj EMC [(r)-32(ole )]TJ 0.104 Tw -1.296 -1.25 Td (of)Tj /Span<>> BDC ( )Tj EMC 1.152 0 Td [(t)-13(he )0.5(pl)-16(a)15(tele)-11.9(t-r)-37(ich )0.5(pl)-16(as)26(ma )0.5(in )0.5(a)-17(cceler)-32.9(a)15(t)-32(ing )0.5(t)-13(he)]TJ /Span<>> BDC ( )Tj EMC 18.404 0 Td [(w)-14(ound-heal)-30.9(ing p)25.1(r)-32(o)]TJ 0 Tw (-)Tj 0.253 Tw -19.555 -1.25 Td [(cess )0.6(and )0.5(r)-24(ecover)-23.9(y )0.6(in )0.5(p)32(a)15(t)-32(ients )0.6(being )0.6(oper)-33(a)15(ted )0.6(for )0.5(pil)30.1(onid)42(al )0.5(sinus )]TJ 0.108 Tw T* [(disease: p)25(r)-24(el)-30.9(iminar)-24(y r)-23.9(esul)56(ts. )]TJ /T1_2 1 Tf [(W)29(orld J Surg)]TJ /T1_0 1 Tf [(. 2009 A)10(ug;33\(8\):1764\2269. )]TJ 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1007/s00268-009-0046-y)Tj 0 0 0 1 k /GS1 gs 0.264 Tw -1.847 -1.25 Td (5.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (Gohar)Tj /Span<>> BDC ( )Tj EMC 2.831 0 Td [(MM, )0.5(Al)-31(i)]TJ /Span<>> BDC ( )Tj EMC 3.635 0 Td [(RF, )0.5(Is)26(mail)]TJ /Span<>> BDC ( )Tj EMC [(KA, )0.5(e)-12(t)]TJ /Span<>> BDC ( )Tj EMC 7.671 0 Td [(al. )0.5(Assess)26(ment )0.5(of)]TJ /Span<>> BDC ( )Tj EMC [(t)-12.9(he ef)-56(fec)-15.9(t )]TJ 0.143 Tw -15.433 -1.25 Td (of)Tj /Span<>> BDC ( )Tj EMC 1.19 0 Td [(pl)-16(a)15(tele)-11.9(t )0.5(r)-37(ich )0.6(pl)-16(as)26(ma )0.6(on )0.5(t)-13(he)]TJ /Span<>> BDC ( )Tj EMC 11.755 0 Td [(heal)-31(ing )0.6(of)]TJ /Span<>> BDC ( )Tj EMC 4.603 0 Td [(oper)-33(a)15(ted )0.6(sa)-17(cr)-32(o)-16(co)-16(ccygeal )]TJ 0.157 Tw -17.548 -1.25 Td [(pil)30(onid)42(al sinus b)12(y l)-16(a)15(y-open technique: a)]TJ /Span<>> BDC ( )Tj EMC [(r)-33(and)-16(omized cl)-31(inical tr)-37(ial. )]TJ /T1_2 1 Tf -0.037 Tw T* (BMC Surg)Tj /T1_0 1 Tf [(. 2020 Sep 22;20\(1\):212. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1186/s12893-020-00865-x)Tj 0 0 0 1 k /GS1 gs 0.224 Tw T* (6.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (Boztug)Tj /Span<>> BDC ( )Tj EMC 3.292 0 Td [(CY, K)-15.9(ar)-33(aa)-17(ga)-17(c)]TJ /Span<>> BDC ( )Tj EMC [(A)15(T, )0.5(Benl)-31(ice)]TJ /Span<>> BDC ( )Tj EMC [(C, )0.5(e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Pl)-15.9(a)15(tele)-12(t-r)-36.9(ich pl)-16(as)26(ma )]TJ -0.008 Tw -4.588 -1.25 Td [(tr)-24(ea)15(tment im)10.1(p)25(r)-32(oves post)17(oper)-33(a)15(t)-32(i)-15.9(ve r)-24(ecover)-24(y in p)32(a)15(t)-32(ients wi)-24(t)-13(h pil)30(onid)42(al )]TJ 0.065 Tw T* (sinus disease: a)Tj /Span<>> BDC ( )Tj EMC [(r)-33(and)-16(omized contr)-32(olled cl)-31(inical)56.1(tr)-37(ial. )]TJ /T1_2 1 Tf (BMC Surg)Tj /T1_0 1 Tf (. 2021 )Tj 0.023 Tw T* [(O)-16(c)-16(t 21;21\(1\):373. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1186/s12893-021-01370-5)Tj 0 0 0 1 k /GS1 gs 0.044 Tw T* (7.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (\202\004\022\026\f\024\r)Tj /Span<>> BDC ( )Tj EMC (\213.\213., \207\036\031\020\035\024\r)Tj /Span<>> BDC ( )Tj EMC (\225.\203., \211\035\034\016\027\024\r)Tj /Span<>> BDC ( )Tj EMC (\202.\202., \017 \f\024\026\r\021. \215\030\017\n\036\027\036\027\017\036\ )Tj 0.167 Tw -1.296 -1.25 Td (\026\031\021\024\023\035\026\n\t, \024\002\024\020\026\013\036\027\027\024\ \005 \021\030\024\n\002\024\006\017\021\026\n\017, \r)Tj /Span<>> BDC ( )Tj EMC (\022\035\017\027\017\004\036\f\022\024\005 \023\030\026\022\021\017)Tj 0 Tw (-)Tj T* (\022\036. )Tj /T1_2 1 Tf 1.606 0 Td (\210\022\034\006\016\b\022\007\022\020\037)Tj /T1_0 1 Tf 0.149 Tw [(. 2013;\(4\): 46-59. /A)-25(chk)-16.9(asov)]TJ /Span<>> BDC ( )Tj EMC [(E.E., Bezugl)30(ov)]TJ /Span<>> BDC ( )Tj EMC (E.N., )Tj 0.175 Tw -1.606 -1.25 Td [(Ul)35(y)22(anov)]TJ /Span<>> BDC ( )Tj EMC [(A.A., e)-12(t al. Appl)-30.9(ica)15(t)-32(ion of)]TJ /Span<>> BDC ( )Tj EMC [(pl)-16(a)15(tele)-12(t-enr)-36.9(iched aut)17(opl)-16(as)26(m in )]TJ 0.023 Tw T* [(cl)-31(inical p)25(r)-33(a)-17(c)-16(t)-32(ice. )]TJ /T1_2 1 Tf 0 Tw (Biomedicine)Tj /T1_0 1 Tf 0.023 Tw (. 2013;\(4\): 46-59. \(In Russ.\).)Tj 0.017 Tw 29.055 38.75 Td (8.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(L)-32(iber)-32.9(a)15(t)-32(i)]TJ /Span<>> BDC ( )Tj EMC [(A, Al)56.1(tman)]TJ /Span<>> BDC ( )Tj EMC [(D, T)40(e)-12(tzl)-15.9(af)-56(f)]TJ /Span<>> BDC ( )Tj EMC [(J. T)47(he)]TJ /Span<>> BDC ( )Tj EMC [(PRISMA st)15(a)15(tement for r)-24(epor)-21.9(t)]TJ 0 Tw (-)Tj 0.255 Tw -1.296 -1.25 Td [(ing sy)-13(stema)15.1(t)-32(ic r)-24(ev)-15.9(iews and me)-12(t)15(a-anal)35.1(y)-13(ses of)]TJ /Span<>> BDC ( )Tj EMC [(studies t)-12.9(ha)15(t ev)-15(al)35(u)]TJ 0 Tw (-)Tj 0.295 Tw T* [(a)15(te heal)56.1(t)-13(hcar)-24(e inter)-32(vent)-32(ions: e)-18(xpl)-16(ana)15.1(t)-32(ion and el)-15.9(abor)-33(a)15(t)-32(ion. )]TJ /T1_2 1 Tf 0 Tw (BMJ)Tj /T1_0 1 Tf (. )Tj 0.023 Tw T* [(2009;339:b2700. d)-15.9(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1136/bmj.b2700)Tj 0 0 0 1 k /GS1 gs 0.253 Tw T* (9.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Mehr)-33(abi Bahar)]TJ /Span<>> BDC ( )Tj EMC [(M, Al)-31(i Akbar)-37(ian)]TJ /Span<>> BDC ( )Tj EMC [(M, A)-23.9(zadmand)]TJ /Span<>> BDC ( )Tj EMC [(A. Invest)-32(iga)15(t)-32(ing )]TJ 0.196 Tw -1.296 -1.25 Td [(t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(ef)-56(fec)-16(t of)]TJ /Span<>> BDC ( )Tj EMC [(aut)17(ol)30(o)-16(gous pl)-16(a)15(tele)-11.9(t-r)-37(ich pl)-16(as)26(ma on p)32(ain in p)32.1(a)14.9(t)-31.9(ients )]TJ -0.002 Tw T* [(wi)-24(t)-12.9(h pil)30(onid)42(al abscess tr)-23.9(ea)15(ted wi)-24(t)-13(h sur)-31.9(gical r)-24(emov)-14.9(al of)]TJ /Span<>> BDC ( )Tj EMC [(e)-18(xtensi)-15.9(ve t)-32(is)]TJ 0 Tw (-)Tj T* (sue. )Tj /T1_2 1 Tf 0.032 Tw 1.935 0 Td [(Iran R)21(ed Crescent Med)]TJ /Span<>> BDC ( )Tj EMC (J)Tj /T1_0 1 Tf [(. 2013 N)-13.9(ov;15\(11\):e6301. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.5812/)Tj -1.935 -1.25 Td [(ir)-32(cmj.6301)]TJ 0 0 0 1 k /GS1 gs 0.005 Tc 0.349 Tw T* (10.)Tj /Span<>> BDC ( )Tj EMC 1.814 0 Td [(\202\004\022)0.5(\026\f\024\r)]TJ /Span<>> BDC ( )Tj EMC [(\213.\213.)0.5(, \211\035)0.5(\034\016\027\024)0.5(\r)]TJ /Span<>> BDC ( )Tj EMC [(\202)0.5(.\202., \207\036\031)0.5(\020\035\024\r)]TJ /Span<>> BDC ( )Tj EMC [(\225.\203.)0.5( \236\f\023)0.5(\024\035\034\024)0.5(\r\026\027\017\036)5( )]TJ 0.004 Tc 0.35 Tw -1.814 -1.25 Td [(\026\031\021\024\023\035\026\n\t, )0.5(\024\002\024\020\026\013\036\027\027\024\005 )0.5(\021\030\024\n\002\024\006\017\021\026\030\027\t\n\017 )0.5(\235\026\022\021\024\030\026\n\017 )0.5(\030\024\f\021\026,)4( )]TJ 0.003 Tc T* (\r)Tj /Span<>> BDC ( )Tj EMC [(\035\036\004\036\027\017\017 )0.5(\002\024\035\034\027\t\b \f)]TJ /Span<>> BDC ( )Tj EMC [(\026\002\f\006\036\f\f\024\n \220\023\017\021\036\035\017\026\035\034\027\ \024\020\024 \022\024\023\004\017\022\024\r\024\020\024)3( )]TJ 0.008 Tc -0.008 Tw T* [(\b)0.5(\024)0.5(\007)0.6(\026)0.5(.)0.5( )]TJ /T1_2 1 Tf 2.825 0 Td [(\212)0.5(\022)0.5(\033)0.6(\023)0.5(\033)0.5(\013)0.5(\022)0.6(\030)]TJ /T1_0 1 Tf 0.349 Tw 3.776 0 Td [(.)0.5( 2)0.5(0)0.5(1)0.5(3)0.5(;)0.6(1)0.5(2)0.5(:)0.5(4)0.5(3)0.6(\226)0.5(4)0.5(7)0.5(.)0.5( /)0.5(A)-24.5(c)0.5(h)0.6(k)-16.5(a)0.5(s)0.5(o)0.5(v)]TJ /Span<>> BDC 12.352 0 Td ( )Tj EMC [(E)0.6(.)0.5(E)0.5(.)0.6(,)0.5( U)0.6(l)35.5(y)22.5(a)0.5(n)0.5(o)0.5(v)]TJ /Span<>> BDC 6.18 0 Td ( )Tj EMC [(A)0.6(.)0.5(A)0.5(.)0.6(,)8( )]TJ 0 Tc 0.099 Tw -25.133 -1.25 Td [(Bezugl)30.1(ov)]TJ /Span<>> BDC ( )Tj EMC (E.N. Use of)Tj /Span<>> BDC ( )Tj EMC [(aut)17(opl)-15.9(as)26(m enr)-36.9(iched wi)-24(t)-13(h pl)-16(a)15(tele)-11.9(t gr)-31.9(o)-14(w)-24(t)-13(h f)16(a)-17(c)]TJ 0 Tw (-)Tj 0.076 Tw T* [(t)17(or)-10(s in t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(tr)-24(ea)15(tment of)]TJ /Span<>> BDC ( )Tj EMC [(p)32(a)15(t)-32(ients wi)-24(t)-13(h epi)-23.9(t)-13(hel)-31(ial co)-16(ccygeal abscess. )]TJ /T1_2 1 Tf 0 Tw T* [(Surg)12(er)-43(y.)]TJ /T1_0 1 Tf 0.023 Tw ( 2013;12:43\22647. \(In Russ.\).)Tj 0.004 Tc 0.35 Tw T* (11.)Tj /Span<>> BDC ( )Tj EMC 1.812 0 Td [(M)-24.1(ohammadi)]TJ /Span<>> BDC ( )Tj EMC 5.48 0 Td [(S, Nasir)-37(i)]TJ /Span<>> BDC ( )Tj EMC 4.205 0 Td [(S, M)-24.1(ohammadi)]TJ /Span<>> BDC ( )Tj EMC [(MH, )0.5(e)-12.1(t)]TJ /Span<>> BDC ( )Tj EMC 10.21 0 Td [(al. )0.5(Ev)-15.1(al)35(ua)14.9(t)-32(ion)4( )]TJ 0 Tc 0.062 Tw -21.707 -1.25 Td (of)Tj /Span<>> BDC ( )Tj EMC 1.109 0 Td [(pl)-16(a)15(tele)-11.9(t-r)-37(ich )0.6(pl)-16(as)26(ma )0.5(gel )0.6(po)17(tent)-32(ial )0.5(in )0.6(a)-17(cceler)-33(a)15(t)-31.9(ion )0.5(of)]TJ /Span<>> BDC ( )Tj EMC 21.493 0 Td [(w)-14(ound )0.6(heal)]TJ 0 Tw (-)Tj 0.133 Tw -22.602 -1.25 Td [(ing dur)-33(a)15(t)-32(ion in p)32(a)15(t)-32(ients under)-37.9(went pil)30(onid)42(al sinus sur)-32(ger)-24(y: A)]TJ /Span<>> BDC ( )Tj EMC [(r)-32.9(an)]TJ 0 Tw (-)Tj 0.173 Tw T* [(d)-16(omized contr)-32(olled p)32(ar)-33(allel cl)-31(inical tr)-36.9(ial. )]TJ /T1_2 1 Tf [(T)56(ransfus Apher Sci.)]TJ /T1_0 1 Tf ( 2017 )Tj 0.023 Tw T* [(Ap)25(r;56\(2\):226\226232. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw [(10.1016/j.tr)-32.9(ansc)-24(i.2016.12.032)]TJ 0 0 0 1 k /GS1 gs 0.015 Tw T* (12.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(De P)40(ascale)]TJ /Span<>> BDC ( )Tj EMC [(MR, S)-16(ommese)]TJ /Span<>> BDC ( )Tj EMC (L, Casamassimi)Tj /Span<>> BDC ( )Tj EMC 16.233 0 Td [(A, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Pl)-16(a)15(tele)-11.9(t der)-37(i)-16(v)-15(a)]TJ 0 Tw (-)Tj 0.13 Tw -18.029 -1.25 Td [(t)-32(i)-16(ves in r)-24(egener)-33(a)15(t)-32(i)-15.9(ve medic)-23.9(ine: an)]TJ /Span<>> BDC ( )Tj EMC [(upd)42(a)15(te. )]TJ /T1_2 1 Tf [(T)56(ransfus Med R)21(ev)]TJ /T1_0 1 Tf (. 2015 )Tj 0.023 Tw T* [(Jan;29\(1\):52\22661. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw [(10.1016/j.tmr)-31.9(v.2014.11.001)]TJ 0 0 0 1 k /GS1 gs 0.299 Tw T* (13.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Ul)35(usal K)-16(an ve K)-15.9(an Bile\275enler)-36.9(i Ha)-23.9(z\276r)-30(l)-16(ama K)25(ull)-15.9(an\276m ve K)-16(al)-31(i)-23.9(te )]TJ 0.255 Tw -1.796 -1.25 Td [(G\374vencesi R)13(ehber)-36.9(i. 2016. )-0.6(URL: ht)-30(tps://k)-17(anver.or)-31.9(g/U)13(pl)30(oad/Dosy)22(a/)]TJ 0.023 Tw T* [(ul)35(usal_k)-16.9(an_r)-24(ehber)-37(i.pdf \(In T)60(ur)-24(k.\))]TJ -0.044 Tw T* (14.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Higgins)Tj /Span<>> BDC ( )Tj EMC 3.265 0 Td [(JP, )0.5(Al)56(tman)]TJ /Span<>> BDC ( )Tj EMC 4.336 0 Td [(D\217, )0.5(G\370tzsche)]TJ /Span<>> BDC ( )Tj EMC 5.249 0 Td [(PC. )0.5(T)47(he)]TJ /Span<>> BDC ( )Tj EMC 3.051 0 Td [(Co)-16(chr)-33(ane )0.5(Coll)-15.9(abor)-33(a)15(t)-32(ion\246s )]TJ 0.326 Tw -17.697 -1.25 Td [(t)17(o)-16(ol for assessing r)-37(isk of)]TJ /Span<>> BDC ( )Tj EMC [(bias in r)-33(and)-16(omised tr)-36.9(ials. )]TJ /T1_2 1 Tf (Br Med J.)Tj /T1_0 1 Tf 0 Tw ( )Tj 0.023 Tw T* [(2011;343:889\226893. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1136/bmj.d5928)Tj 0 0 0 1 k /GS1 gs 0.01 Tc 0.354 Tw T* [(1)0.5(5)0.6(.)]TJ /Span<>> BDC 1.324 0 Td ( )Tj EMC 0.509 0 Td [(\207)0.5(\026)0.6(\035)0.5(\026)0.6(\006)0.5(\022)0.5(\017)0.6(\005)]TJ /Span<>> BDC 4.037 0 Td ( )Tj EMC [(\213)0.5(.)0.6(\217)0.5(.)0.6(,)0.5( \212)0.5(\036)0.6(\n)0.5(\004)0.5(\031)0.6(\022)]TJ /Span<>> BDC 6.079 0 Td ( )Tj EMC [(\200)0.5(.)0.6(\210)0.5(.)0.6( 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\r\025\b\222\001\t\016\215\021\004 \242\222\021\026)11(\016\t\021\001\t\214\215\025\202)10.1(\025 \017)10(\025\222\f\021\017)10(\025\r\025\202)10(\025 \025\211\001 )]TJ T* [(\(\b\021\b)-10(\026)11(\016\024\001\026\021\f\016\b\017\021\207 \025\235\213\025\201 \t\021\026\ )11(\016\201\001\026)-20(\200\201\220 \021\022\024\016\026)11(\001\001\215\001\t\021\213\))]TJ 41.398 3 Td (A platelet rich plasma for pilonidal sinus disease )Tj 4.085 -1 Td [(\(s)10(y)10(stematic r)31(e)11(vie)11(w and meta-analy)10(sis\))]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0.033 Tw 10 0 0 10 42.5197 724.8299 Tm (\023\024\007\004\036\030\022\017\r\026\033\021 \027\036\024\002\b\024\007\ \017\n\024\f\021\034 \023\030\017\n\036\027\036\027\017\016 \023\026\030\ \026\006\036\021\026)Tj 0 Tw (-)Tj 0.096 Tw 0 -1.218 TD (\n\024\035\026 500)Tj /Span<>> BDC ( )Tj EMC (\n\020 3 \030\026\026 \r)Tj /Span<>> BDC ( )Tj EMC (\007\036\027\034 \r)Tj /Span<>> BDC ( )Tj EMC (\022\026\004\036\f\021\r\036 \024\002\036\002\024\035\017\r\026\033)Tj 0 Tw (-)Tj 0.173 Tw T* (\013\036\020\024 \023\030\036\023\026\030\026\021\026 \r\r\017\007\031 \021\ \024\020\024, \004\021\024 \027\036\f\021\036\030\024\017\007\027\t\036 \ \023\030\024)Tj 0 Tw (-)Tj 0.423 Tw T* [(\021\017\r\024\r\024\f\023\026\035\017\021\036\035\034\027\t\036 )0.6(\f\030\036\007\f\021\r\026 )0.6(\027\026\030\031\001\026\033\021 )0.5(\235\031\027\022\006\017\033 )]TJ 0 Tw T* (\021\030\024\n\002\024\006\017\021\024\r.)Tj 0.204 Tw T* [(\206\024\r\024\030\016 )0.5(\024)]TJ /Span<>> BDC ( )Tj EMC 4.256 0 Td [(\002\036\024\023\026\f\027\024\f\021\017 )0.6(\f\024\004\036\021\026\027\027\024\005 )0.6(\n\036\021\024\007\017\022\017 )0.5(\035\036\004\036)]TJ 0 Tw (-)Tj 0.201 Tw -4.256 -1.218 Td (\027\017\016 \b\030\024\027\017\004\036\f\022\024\020\024 \r\024\f\023\026\ \035\036\027\017\016 \220\023\017\021\036\035\017\026\035\034\027\024\020\ \024 \022\024\023)Tj 0 Tw (-)Tj 0.263 Tw T* (\004\017\022\024\r\024\020\024 \b\024\007\026, \n\t \023\024\007\030\026\ \031\n\036\r\026\036\n \030\026\r\027\031\033 \r\036\030\024\016\021)Tj 0 Tw (-)Tj 0.064 Tw T* (\027\024\f\021\034 \030\026\r\017\021\017\016 \023\024\f\035\036\024\023\ \036\030\026\006\017\024\027\027\t\b \024\f\035\024\032\027\036\027\017\005\ \022\026\022 )Tj 0.026 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\f\035\031\004\026\036 \n\036\f\021\027\024\020\024 \023\030\017\n\036\027\ \036\027\017\016 PRP \r)Tj /Span<>> BDC ( )Tj EMC (\f\024\004\036\021\026\027\017\017 \f)Tj /Span<>> BDC ( )Tj EMC (\017\f)Tj 0 Tw (-)Tj 0.199 Tw T* (\f\036\004\036\027\017\036\n \225\025\216 \f)Tj /Span<>> BDC ( )Tj EMC (\024\021\022\030\t\021\t\n \f\023\024\f\024\002\024\n \r\036\007\036\027\ \017\016 \030\026\027\t, )Tj 0.05 Tw T* (\021\026\022 \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\017 \017\024\035\017\030\024\r\026\027\027\024\n \017\f\f\036\004\ \036\027\017\017 \225\025\216 \f)Tj /Span<>> BDC ( )Tj EMC (\024\021\022\030\t\021\t\n )Tj 0.199 Tw 0 -1.218 TD (\f\023\024\f\024\002\024\n \r\036\007\036\027\017\016 \030\026\027\t \007\ \035\016 \035\036\004\036\027\017\016 \b\030\024\027\017\004\036\f\022\024\ \020\024 )Tj 0.174 Tw 0 -1.218 TD [(\r\024\f\023\026\035\036\027\017\016 )0.6(\225\025\216. )0.5(\200)]TJ /Span<>> BDC ( )Tj EMC 8.392 0 Td [(\b\024\007\036 )0.5(\023\030\024\r\036\007\036\027\027\024\020\024 )0.6(\n\036\021\026\026\027\026\035\017\026 )]TJ -0.011 Tw -8.392 -1.218 Td (\f\021\026\021\017\f\021\017\004\036\f\022\017 \027\026\004\017\n\024\005\ \030\026\027\017\006\t \007\024\f\021\017\020\027\031\021\024 \027\036\ \002\t\035\024 )Tj 0.111 Tw 0 -1.218 TD (\(\210\221)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (3,92, 95% \212\236:)Tj /Span<>> BDC ( )Tj EMC (1,01\22615,22, )Tj /T1_2 1 Tf 0 Tw (p)Tj /T1_1 1 Tf 0.111 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,05\) \r\r\017\007\031 \024\021)Tj 0 Tw (-)Tj 0.315 Tw T* (\f\031\021\f\021\r\017\016 \007\026\027\027\t\b \024\002 \024\f\035\024\032\ \027\036\027\017\016\b \r)Tj /Span<>> BDC ( )Tj EMC (\017\f\f\035\036\007\024\r\026\027\017\017 )Tj -0.015 Tw T* (Boztug)Tj /Span<>> BDC ( )Tj EMC (C.Y. \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. [6] \017)Tj /Span<>> BDC ( )Tj EMC (\024\023\017\f\026\027\017\016 \024\f\035\024\032\027\036\027\017\005 \021\ \024\035\034)Tj 0 Tw (-)Tj 0.005 Tw T* (\022\024 \r)Tj /Span<>> BDC ( )Tj EMC [(\023\031\002\035\017\022\026\006\017\017 Gohar )0.5(M.M. \017)]TJ /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. [5]. \211)Tj /Span<>> BDC ( )Tj EMC (\024\f\021\026\035\034\027\t\b )Tj 0.036 Tw T* (\023\026\006\017\036\027\021\024\r \r)Tj /Span<>> BDC ( )Tj EMC [(\021\030\031\007\026\b M)-24(ohammadi)]TJ /Span<>> BDC ( )Tj EMC (S. [3] \017)Tj /Span<>> BDC ( )Tj EMC [(Spyr)-37(id)42(ak)-16(is)]TJ /Span<>> BDC ( )Tj EMC (\204. )Tj 0.167 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. [4] \r)Tj /Span<>> BDC ( )Tj EMC (\024\002\036\017\b \020\030\031\023\023\026\b \024\f\035\024\032\027\036\ \027\017\005 \027\036 \002\t\035\024. )Tj 0.023 Tw T* (\225\021\024\021 \235\026\022\021, \023\024-\r\017\007\017\n\024\n\031, \ \024\002\031\f\035\024\r\035\036\027 \021\036\n, \004\021\024 \021\030\024\ \n\002\024)Tj 0 Tw (-)Tj 0.045 Tw T* [(\006\017\021\t )0.5(\b\030\026\027\016\021 )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC 6.144 0 Td [(\r\023\024\f\035\036\007\f\021\r\017\017 )0.6(\f\036\022\030\036\021\017\030\031\033\021 )0.5(\026\027\021\017\002\026\022\021\036)]TJ 0 Tw (-)Tj 0.105 Tw -6.144 -1.218 Td (\030\017\026\035\034\027\t\036 \017)Tj /Span<>> BDC ( )Tj EMC (\235\031\027\020\017\006\017\007\027\t\036 \002\036\035\022\017, \f\023\024\ \f\024\002\027\t\036 \023\030\036\007\024\021)Tj 0 Tw (-)Tj T* (\r\030\026\013\026\021\034 \017\027\235\017\006\017\030\024\r\026\027\017\ \036 \030\026\027\t [24].)Tj -0.016 Tw T* (\215\030\036\007\024\023\036\030\026\006\017\024\027\027\026\016 \026\027\ \021\017\002\017\024\021\017\022\024\023\030\024\235\017\035\026\022\021\ \017\022\026 \r)Tj /Span<>> BDC ( )Tj EMC (\024\002\255)Tj 0 Tw (-)Tj -0.08 Tw T* (\036\n\036 1 \007\024\t \026\027\021\017\002\026\022\021\036\030\017\026\ \035\034\027\024\020\024 \023\030\036\023\026\030\026\021\026 \r\027\031\ \021\030\017\r\036\027)Tj 0 Tw (-)Tj 0.103 Tw T* (\027\024 \007\024)Tj /Span<>> BDC ( )Tj EMC (\024\023\036\030\026\021\017\r\027\024\020\024 \r\n\036\001\026\021\036\035\ \034\f\021\r\026 \002\t\035\026 \r\t\023\024\035\027\036\027\026 )Tj 0.096 Tw T* (\023\026\006\017\036\027\021\026\n \r)Tj /Span<>> BDC ( )Tj EMC [(75% \023\031\002\035\017\022\026\006\017\016\b [3\2265]. M)-24(ohammadi)]TJ /Span<>> BDC ( )Tj EMC (S. )Tj 0.058 Tw T* ([3] \017)Tj /Span<>> BDC ( )Tj EMC (Gohar)Tj /Span<>> BDC ( )Tj EMC (M.M. [5] \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. \r\r\024\007\017\035\017 \023\026\006\017\036\027\021\026\ \n \006\036)Tj 0 Tw (-)Tj 0.15 Tw T* [(\235\026\035\024\f\023\024\030\017\027\t, )0.5(\026)]TJ /Span<>> BDC ( )Tj EMC [(Spyr)-36.9(id)42(ak)-16(is)]TJ /Span<>> BDC ( )Tj EMC [(\204. )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC [(\f\024\026\r\021. )0.5([4])]TJ /Span<>> BDC ( )Tj EMC [(\227 )0.5(\023\036\027\017)]TJ 0 Tw (-)Tj 0.223 Tw T* (\006\017\035\035\017\027 \001\017\030\024\022\024\020\024 \f\023\036\022\ \021\030\026 \007\036\005\f\021\r\017\016 \f)Tj /Span<>> BDC ( )Tj EMC (\017\027\020\017\002\017\021\024\030\024\n )Tj 0.319 Tw T* (\002\036\021\026-\035\026\022\021\026\n\026. \202\027\021\017\002\017\024\ \021\017\022\024\021\036\030\026\023\017\016 \r)Tj /Span<>> BDC ( )Tj EMC (\023\024\f\035\036\024\023\036\030\026)Tj 0 Tw (-)Tj 0.194 Tw T* (\006\017\024\027\027\024\n \023\036\030\017\024\007\036 \r\t\023\024\035\ \027\016\035\026\f\034 \023\026\006\017\036\027\021\026\n \r)Tj /Span<>> BDC ( )Tj EMC (\017\f\f\035\036)Tj 0 Tw (-)Tj 0.175 Tw T* [(\007\024\r\026\027\017\017 M)-24(ohammadi)]TJ /Span<>> BDC ( )Tj EMC (S. \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. [3], \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\n \022\031\030\f )Tj 0.284 Tw T* (\035\036\004\036\027\017\016 \024\023\030\036\007\036\035\016\035\f\016 \ \220\n\023\017\030\017\004\036\f\022\017. \236\f\f\035\036\007\024\r\026\ \021\036\035\017 )Tj 0.142 Tw T* (\024\021\n\036\004\026\035\017 \023\030\016\n\031\033 \023\024\035\024\032\ \017\021\036\035\034\027\031\033 \f\r\016\034 \n\036\032\007\031 \r\030\ \036)Tj 0 Tw (-)Tj 0.008 Tw T* (\n\036\027\036\n \026\032\017\r\035\036\027\017\016 \030\026\027\t \017\ )Tj /Span<>> BDC ( )Tj EMC (\023\030\024\007\024\035\032\017\021\036\035\034\027\024\f\021\034\033 \023\ \030\017)Tj 0 Tw (-)Tj -0.045 Tw T* (\201\n\026 \026\027\021\017\002\017\024\021\017\022\024\r, \031\021\r\036\ \030\032\007\026\016 \021\036\n \f\026\n\t\n, \004\021\024 \007\035\017\021\ \036\035\034)Tj 0 Tw (-)Tj 0.277 Tw T* (\027\024\036 \017\f\023\024\035\034\024\r\026\027\017\036 \026\027\021\017\ \002\026\022\021\036\030\017\026\035\034\027\t\b \023\030\036\023\026\030\ \026\021\024\r )Tj 0.424 Tw T* (\031\f\022\024\030\016\036\021 \023\030\024\006\036\f\f \026\032\017\r\035\ \036\027\017\016 \030\026\027\036\r\024\020\024 \007\036\235\036\022\021\ \026. )Tj 0.157 Tw T* [(Spyr)-37(id)42(ak)-15.9(is)]TJ /Span<>> BDC ( )Tj EMC (\204. [4] \017)Tj /Span<>> BDC ( )Tj EMC (Gohar)Tj /Span<>> BDC ( )Tj EMC (M.M. [5] \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. \024\020\030\026\027\017)Tj 0 Tw (-)Tj 0.206 Tw T* (\004\017\r\026\035\017\f\034 \035\017\001\034 \024\007\027\024\022\030\026\ \021\027\t\n \r\r\036\007\036\027\017\036\n \026\027\021\017\002\026\022\ \021\036)Tj 0 Tw (-)Tj 0.144 Tw T* (\030\017\026\035\034\027\024\020\024 \023\030\036\023\026\030\026\021\026\ \r)Tj /Span<>> BDC ( )Tj EMC (\022\026\004\036\f\021\r\036 \023\036\030\017\024\023\036\030\026\006\017\ \024\027\027\024\005 )Tj 0.027 Tw T* (\026\027\021\017\002\017\024\021\017\022\024\023\030\024\235\017\035\026\ \022\021\017\022\017, \026)Tj /Span<>> BDC ( )Tj EMC (Boztug)Tj /Span<>> BDC ( )Tj EMC (C.Y. \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. [6] )Tj 0.153 Tw T* (\027\036 \023\030\024\r\024\007\017\035\017 \023\026\006\017\036\027\021\ \026\n \027\017 \026\027\021\017\002\017\024\021\017\022\024\023\030\024\ \235\017\035\026\022)Tj 0 Tw (-)Tj T* (\021\017\022\031, \027\017 \026\027\021\017\002\017\024\021\017\022\024\021\ \036\030\026\023\017\033.)Tj 0.267 Tw T* (\224\027\017\032\036\027\017\036 \023\036\030\017\024\007\026 \r\030\036\ \n\036\027\027\024\005 \027\036\021\030\031\007\024\f\023\024\f\024\002\027\ \024\f\021\017 )Tj 0.038 Tw T* (\023\024\f\035\036 \023\030\024\r\036\007\036\027\027\024\020\024 \024\023\ \036\030\026\021\017\r\027\024\020\024 \r\n\036\001\026\021\036\035\034\f\ \021\r\026)Tj /Span<>> BDC ( )Tj EMC (\227 )Tj 0.315 Tw T* (\022\035\033\004\036\r\026\016 \f\024\006\017\026\035\034\027\024-\220\022\ \024\027\024\n\017\004\036\f\022\026\016 \026\007\026\004\026, \006\036\ \035\034\033 )Tj 0.018 Tw T* (\022\024\021\024\030\024\005 \016\r\035\016\036\021\f\016 \027\036 \021\024\ \035\034\022\024 \030\036\026\002\017\035\017\021\026\006\017\016 \023\026\ \006\017\036\027\021\024\r )Tj 0.058 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\017\b \r\024\r\030\026\013\036\027\017\036 \022)Tj /Span<>> BDC ( )Tj EMC (\r\t\023\024\035\027\036\027\017\033 \023\030\024\235\036\f\f\017\024\027\ \026\035\034\027\t\b )Tj 0.198 Tw T* [(\024\002\016\026\027\027\024\f\021\036\005, )0.6(\027\024 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 8.697 0 Td [(\f\027\017\032\036\027\017\036 )0.6(\n\026\021\036\030\017\026\035\034\027\t\b )0.5(\026\021\030\026\021 )]TJ 0.148 Tw -8.697 -1.218 Td (\020\024\f\031\007\026\030\f\021\r\026 \027\026)Tj /Span<>> BDC ( )Tj EMC (\024\023\035\026\021\031 \002\024\035\034\027\017\004\027\t\b \035\017\f\ \021\024\r. \204\036\f\021\027\024\036 )Tj 0.056 Tw 23.244 64.543 Td [(\023\030\017\n\036\027\036\027\017\036 )0.5(PRP )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC [(\f\024\004\036\021\026\027\017\017 )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC [(\017\f\f\036\004\036\027\017\036\n )0.5(\225\025\216 )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC (\024\021)Tj 0 Tw (-)Tj 0.078 Tw T* (\022\030\t\021\t\n \f\023\024\f\024\002\024\n \r\036\007\036\027\017\016\ \030\026\027\t \007\035\016 \035\036\004\036\027\017\016 \b\030\024\027\ \017)Tj 0 Tw (-)Tj -0.038 Tw T* (\004\036\f\022\024\020\024 \r\024\f\023\026\035\036\027\017\016 \225\025\ \216 \007\024\022\026\026\035\024 \f\r\024\036 \023\030\036\017\n\031\013\ \036\f\021\r\024 )Tj 0.131 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\r\017\007\036 \f\027\017\032\036\027\017\016 \007\035\017\021\036\035\034\ \027\024\f\021\017 \r\030\036\n\036\027\027\024\005 \027\036\021\030\031\ \007\024)Tj 0 Tw (-)Tj 0.367 Tw T* (\f\023\024\f\024\002\027\024\f\021\017 \(\030\026\027\017\006\026 \f\030\ \036\007\027\017\b)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (12,80, 95% \212\236: )Tj 0 Tw T* (3,62\22621,98, )Tj /T1_2 1 Tf 5.062 0 Td (p)Tj /T1_1 1 Tf 0.218 Tw /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (0,00001\). \217\036\031\035\034\021\026\021\t \017\f\f\035\036\007\024\r\ \026\027\017\005 )Tj 0.013 Tw -5.062 -1.218 Td [(Mehr)-33(abi)]TJ /Span<>> BDC ( )Tj EMC (Bahar)Tj /Span<>> BDC ( )Tj EMC (M. [9] \017)Tj /Span<>> BDC ( )Tj EMC (\202\004\022\026\f\024\r\026)Tj /Span<>> BDC ( )Tj EMC (\213.\213. [10] \f)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021\024\030\026)Tj 0 Tw (-)Tj 0.113 Tw T* (\n\017, \r)Tj /Span<>> BDC ( )Tj EMC 2.439 0 Td [(\f\r\024\033 \024\004\036\030\036\007\034, \021\026\022\032\036 )0.5(\007\036\n\024\027\f\021\030\017\030\031\033\021 )0.5(\f\021\026\021\017\f\021\017)]TJ 0 Tw (-)Tj -0.009 Tw -2.439 -1.218 Td (\004\036\f\022\017 \027\026\004\017\n\024\036 \f\027\017\032\036\027\017\ \036 \023\036\030\017\024\007\026 \r\030\036\n\036\027\027\024\005 \027\036\ \021\030\031)Tj 0 Tw (-)Tj 0.099 Tw T* [(\007\024\f\023\024\f\024\002\027\024\f\021\017 )0.6(\023\030\017)]TJ /Span<>> BDC ( )Tj EMC 8.406 0 Td [(\n\036\f\021\027\024\n )0.5(\017\f\023\024\035\034\024\r\026\027\017\017 )0.6(PRP )0.6(\007\035\016 )]TJ -0.002 Tw -8.406 -1.218 Td [(\035\036\004\036\027\017\016 )0.6(\002\024\035\034\027\t\b )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC 8 0 Td [(\024\f\021\030\t\n )0.5(\r\024\f\023\026\035\036\027\017\036\n )0.6(\225\025\216 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 11.299 0 Td (\f\021\026\007\017\017 )Tj 0 Tw -19.299 -1.218 Td (\026\002\f\006\036\007\017\030\024\r\026\027\017\016 \()Tj /T1_2 1 Tf (p)Tj /T1_1 1 Tf /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (0,00001\).)Tj -0.014 Tw 0 -1.218 TD (\214\017\001\034 \r)Tj /Span<>> BDC ( )Tj EMC (1 \017\f\f\035\036\007\024\r\026\027\017\017 \r)Tj /Span<>> BDC ( )Tj EMC (\007\024\035\020\024\f\030\024\004\027\024\n \023\036\030\017\024\007\036\ \024\006\036)Tj 0 Tw (-)Tj 0.106 Tw 0 -1.218 TD [(\027\017\r\026\035\017 )0.5(\030\017\f\022 \030\026\r\017\021\017\016 )0.5(\030\036\006\017\007\017\r\026 \225\025\216, )0.5(\024\007\027\026\022\024, \027\026\004\036)]TJ 0 Tw (-)Tj 0.173 Tw 0 -1.218 TD [(\027\017\036 \007\026\027\027\024\020\024 \021\036\030\n\017\027\026 )0.5(\027\036 \030\026\f\022\030\t\r\026\035\024\f\034. )0.5(Boztug)]TJ /Span<>> BDC ( )Tj EMC (C.Y. )Tj 0.105 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. \023\030\024\007\036\n\024\027\f\021\030\017\030\024\r\ \026\035\017 \007\026\027\027\t\036 \024\002 \024\021\f\031\021\f\021\r\017\ \017 )Tj 0 Tw T* (\030\036\006\017\007\017\r\026 \026\002\024\035\036\r\026\027\017\016 \r\ )Tj /Span<>> BDC ( )Tj EMC (\f\030\026\r\027\017\r\026\036\n\t\b \020\030\031\023\023\026\b [6].)Tj 0.165 Tw T* (\200 2 \017)Tj /Span<>> BDC ( )Tj EMC (4 \017\f\f\035\036\007\024\r\026\027\017\005 \026\r\021\024\030\t \024\006\ \036\027\017\r\026\035\017 \022\026\004\036\f\021\r\024 )Tj 0.277 Tw T* [(\032\017\027\017 \023\026\006\017\036\027\021\024\r [4,6]. Spyr)-37(id)42(ak)-16(is)]TJ /Span<>> BDC ( )Tj EMC (\204. \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. [4] )Tj 0.254 Tw T* [(\023\030\017\n\036\027\016\035\017 )0.6(\001\022\026\035\031 )0.5(SF-36Q )0.5([25] )0.5(\004\036\030\036 )0.6(3 )0.5(\027\036\007\036\035\017 )0.5(\023\024)]TJ 0 Tw (-)Tj 0.312 Tw T* (\f\035\036 \023\030\024\r\036\007\036\027\027\024\005 \024\023\036\030\026\ \006\017\017 \r)Tj /Span<>> BDC ( )Tj EMC (\f\030\026\r\027\017\r\026\036\n\t\b \020\030\031\023)Tj 0 Tw (-)Tj 0.082 Tw T* (\023\026\b, \026)Tj /Span<>> BDC ( )Tj EMC (Boztug)Tj /Span<>> BDC ( )Tj EMC (C.Y. \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. [6])Tj /Span<>> BDC ( )Tj EMC (\227 \001\022\026\035\t SF-36Q [25] )Tj 0 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (NHP [26] \007\024)Tj /Span<>> BDC ( )Tj EMC (\b\017\030\031\030\020\017\004\036\f\022\024\020\024 \r\n\036\001\026\021\ \036\035\034\f\021\r\026 \017)Tj /Span<>> BDC ( )Tj EMC (\004\036\030\036 )Tj 0.112 Tw T* (3 \027\036\007\036\035\017 \023\024\f\035\036 \027\036\020\024. \200)Tj /Span<>> BDC ( )Tj EMC (\024\002\036\017\b \023\031\002\035\017\022\026\006\017\016\b \f\030\036\ \007\027\017\005 )Tj 0.16 Tw T* (\002\026\035\035 \022\026\004\036\f\021\r\026 \032\017\027\017 \023\026\ \006\017\036\027\021\024\r \n\036\032\007\031 \007\r\031\n\016 \020\030\031\ \023)Tj 0 Tw (-)Tj 0.11 Tw T* (\023\026\n\017 \f\021\026\021\017\f\021\017\004\036\f\022\017 \027\026\004\ \017\n\024 \027\036 \030\026\035\017\004\026\035\f\016, \027\024 \031\030\ \024)Tj 0 Tw (-)Tj 0.077 Tw T* (\r\036\027\034 \023\f\017\b\024\035\024\020\017\004\036\f\022\024\020\024\ \f\021\030\036\f\f\026 \002\t\035 \027\036\f\022\024\035\034\022\024 \r\ \t\001\036 )Tj 0.068 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \017\024\035\017\030\024\r\026\027\027\024\020\ \024 \017\f\f\036\004\036\027\017\016 \225\025\216 \f)Tj /Span<>> BDC ( )Tj EMC (\024\021\022\030\t\021\t\n )Tj 0 Tw T* (\f\023\024\f\024\002\024\n \r\036\007\036\027\017\016 \030\026\027\t.)Tj 0.172 Tw T* (\217\036\033\n\017\030\031\016 \r\t\001\036\017\035\024\032\036\027\027\ \024\036, \n\024\032\027\024 \f\007\036\035\026\021\034 \r\t\r\024\007 )Tj 0.057 Tw T* (\024)Tj /Span<>> BDC ( )Tj EMC (\021\024\n, \004\021\024 \n\036\f\021\027\024\036 \023\030\017\n\036\027\ \036\027\017\036 PRP \023\024\f\035\036 \017\f\f\036\004\036\027\017\016\ )Tj 0.273 Tw T* (\225\025\216 \f)Tj /Span<>> BDC ( )Tj EMC (\024\021\022\030\t\021\t\n \f\023\024\f\024\002\024\n \r\036\007\036\027\ \017\016 \030\026\027\t \016\r\035\016\036\021\f\016 )Tj -0.043 Tw T* [(\023\036\030\f\023\036\022\021\017\r\027\t\n \027\026\023\030\026\r\035\036\ \027\017\036\n )0.5(\007\035\016 \031\035\031\004\001\036\027\017\016 \030\036\031\035\034)]TJ 0 Tw (-)Tj 0.131 Tw T* (\021\026\021\024\r \035\036\004\036\027\017\016 \002\024\035\034\027\t\b\ \f)Tj /Span<>> BDC ( )Tj EMC (\b\030\024\027\017\004\036\f\022\017\n \r\024\f\023\026\035\036\027\017\036\ \n )Tj 0.383 Tw T* [(\225\025\216. )0.5(\215\030\036\017\n\031\013\036\f\021\r\026\n\017 )0.6(\007\024\023\024\035\027\036\027\027\024\020\024 )0.6(\024\002\024\020\026\013\036\027\027\024\005 )]TJ 0.076 Tw T* [(\021\030\024\n\002\024\006\017\021\026\n\017 )0.6(\026\031\021\024\023\035\026\n\024\005 )0.6(\023\024\f\035\036\024\023\036\030\026\006\017\024\027\027\024\020\024 )0.6(\035\036)]TJ 0 Tw (-)Tj 0.064 Tw T* (\004\036\027\017\016 \225\025\216 \016\r\035\016\033\021\f\016: \n\017\027\ \017\n\026\035\034\027\024 \017\027\r\026\017\r\027\t\005 \n\036\021\024\ \007 )Tj -0.032 Tw T* (\023\024\035\031\004\036\027\017\016 \022\024\027\006\036\027\021\030\026\ \021\026 \021\030\024\n\002\024\006\017\021\024\r \017, \f\024\024\021\r\ \036\021\f\021\r\036\027)Tj 0 Tw (-)Tj 0.232 Tw T* (\027\024, \026\031\021\024\035\024\020\017\004\027\t\b \235\026\022\021\024\ \030\024\r \030\024\f\021\026 \017)Tj /Span<>> BDC ( )Tj EMC (\n\027\024\020\017\b \007\030\031\020\017\b )Tj 0.185 Tw T* (\002\017\024\035\024\020\017\004\036\f\022\017 \026\022\021\017\r\027\t\b\ \n\024\035\036\022\031\035, \r\024\n\024\032\027\024\f\021\034 \023\030\ \024)Tj 0 Tw (-)Tj 0.131 Tw T* (\r\036\007\036\027\017\016 \r\n\036\001\026\021\036\035\034\f\021\r\026 \ \r)Tj /Span<>> BDC ( )Tj EMC (\031\f\035\024\r\017\016\b \007\027\036\r\027\024\020\024 \f\021\026\006\ \017)Tj 0 Tw (-)Tj 0.084 Tw T* [(\024\027\026\030\026, \023\030\026\022\021\017\004\036\f\022\017 \027\036\ \017\f\f\016\022\026\036\n\t\005 )0.5(\026\023\026\f \023\036\030\r\017\004\027\024\020\024 )]TJ 0.269 Tw T* (\f\t\030\034\016 \007\035\016 \023\030\017\020\024\021\024\r\035\036\027\ \017\016 PRP)Tj /Span<>> BDC ( )Tj EMC (\227 \022\030\024\r\017 \023\026\006\017\036\027\021\026, )Tj 0 Tw T* (\r\024\n\024\032\027\024\f\021\034 \027\036\024\007\027\024\022\030\026\ \021\027\024\020\024 \n\036\f\021\027\024\020\024 \023\030\017\n\036\027\ \036\027\017\016.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 275.0305 164.6418 Tm [(\020)21(\026\027\r\241\224\034\022\031\034)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0 Tc -0.034 Tw 10 0 0 10 274.9606 140.2858 Tm [(\204\036\f\021\027\024\036 \023\030\017\n\036\027\036\027\017\036 )0.5(\026\031\021\024\023\035\026\n\t, \024\002\024\020\026\013\036\027\027\024\ \005 )0.5(\021\030\024\n)]TJ 0 Tw (-)Tj -0.015 Tw T* (\002\024\006\017\021\026\n\017, \016\r\035\016\036\021\f\016 \220\235\235\ \036\022\021\017\r\027\024\005 \017)Tj /Span<>> BDC ( )Tj EMC (\002\036\024\023\026\f\027\024\005 \n\036\021\024)Tj 0 Tw (-)Tj 0.049 Tw T* [(\007\017\022\024\005 \031\035\031\004\001\036\027\017\016 \030\036\031\035\ \034\021\026\021\024\r )0.5(\024\023\036\030\026\021\017\r\027\024\020\024 \035\036\004\036\027\017\016\ )]TJ 0.196 Tw T* (\b\030\024\027\017\004\036\f\022\024\020\024 \r\024\f\023\026\035\036\027\ \017\016 \220\023\017\021\036\035\017\026\035\034\027\024\020\024 \022\024\ \023\004\017\022\024)Tj 0 Tw (-)Tj -0.11 Tw T* (\r\024\020\024 \b\024\007\026, \024\007\027\026\022\024 \027\026\035\017\ \004\017\036 \f\031\013\036\f\021\r\036\027\027\t\b \024\020\030\026\027\ \017\004\036\027\017\005 )Tj -0.045 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\023\030\036\007\f\021\026\r\035\036\027\027\024\n \n\036\021\026\026\027\ \026\035\017\036 \026\f\021\026\r\035\016\036\021 \024\f\021\024\030\024\ \032\027\024 )Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 0 Tw 7.5 0 0 7.5 42.5197 759.8869 Tm [(\007\003\032)50(\n\n\217\n)-21(\035\030\002)]TJ 53.418 0 Td [(MET)30(A)-41(-)-41.9(ANAL)30(Y)30(SIS)]TJ /T1_4 1 Tf 25 0 0 25 505.5896 56.0378 Tm (149)Tj ET endstream endobj 1433 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.045 Tw 10 0 0 10 70.8661 724.8299 Tm [(\235\026\022\021\024\030 \030\024\f\021\026 \(T)35(GF-\254\), \021\030\024\n\002\024\006\017\021\027\t\005 )0.5(\220\023\017\007\036\030\n\026\035\034\027\t\005 )]TJ 0.223 Tw 0 -1.218 TD (\235\026\022\021\024\030 \030\024\f\021\026 \(PDEGF\), \f\024\f\031\007\017\ \f\021\t\005 \220\027\007\024\021\036\035\017\026\035\034\027\t\005 )Tj 0.505 Tw T* (\235\026\022\021\024\030 \030\024\f\021\026 \(VEGF\), \017\027\f\031\035\ \017\027\024\023\024\007\024\002\027\t\005 \235\026\022\021\024\030 )Tj 0.291 Tw T* (\030\024\f\021\026 1 \(IGF-1\), \235\017\002\030\024\002\035\026\f\021\017\ \004\036\f\022\017\005 \235\026\022\021\024\030 \030\024\f\021\026 )Tj 0.085 Tw T* (\(FGF\) \017)Tj /Span<>> BDC ( )Tj EMC (\220\023\017\007\036\030\n\026\035\034\027\t\005 \235\026\022\021\024\030\ \030\024\f\021\026 \(EGF\) [19\22623]. )Tj 0.216 Tw T* (\230\030\024\n\002\024\006\017\021\026\030\027\t\036 \274-\020\030\026\027\ \031\035\t \021\026\022\032\036 \016\r\035\016\033\021\f\016 \017\f\021\024\ \004)Tj 0 Tw (-)Tj 0.175 Tw 0 -1.218 TD (\027\017\022\024\n \006\017\021\024\022\017\027\024\r, \b\036\n\024\022\017\ \027\024\r \017)Tj /Span<>> BDC ( )Tj EMC (\007\030\031\020\017\b \002\036\035\022\024\r [24], )Tj 0.013 Tw 0 -1.218 TD (\022\024\021\024\030\t\036 \017\020\030\026\033\021 \030\024\035\034 \r)Tj /Span<>> BDC ( )Tj EMC (\f\021\017\n\031\035\017\030\024\r\026\027\017\017 \b\036\n\024\021\026\022\ \f\017\f\026, )Tj -0.015 Tw T* (\022\035\036\021\024\004\027\024\005 \023\030\024\035\017\235\036\030\026\ \006\017\017 \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\030\036\r\026\027\017\017 \022\035\036\021\024\022, \026)Tj /Span<>> BDC ( )Tj EMC (\021\026\022)Tj 0 Tw (-)Tj 0.002 Tw T* (\032\036 \r)Tj /Span<>> BDC ( )Tj EMC (\n\024\007\031\035\016\006\017\017 \026\022\021\017\r\027\024\f\021\017 \ \023\024\007\f\021\030\036\022\026\021\036\035\034\f\022\017\b \n\024\035\ \036)Tj 0 Tw (-)Tj T* (\022\031\035 \017, \021\026\022\017\n \024\002\030\026\024\n, \023\030\017\ \r\035\036\004\036\027\017\017 \035\036\005\022\024\006\017\021\024\r.)Tj 0.499 Tw T* [(\200 \023\030\024\026\027\026\035\017\017\030\024\r\026\027\027\t\b )0.5(\017\f\f\035\036\007\024\r\026\027\017\016\b [3\2266] \024\021)]TJ 0 Tw (-)Tj 0.153 Tw 0 -1.218 TD (\f\031\021\f\021\r\031\036\021 \f\021\026\027\007\026\030\021\017\017\030\ \024\r\026\027\027\t\005 \023\024\007\b\024\007 \022)Tj /Span<>> BDC ( )Tj EMC (\031\f\021\026\027\024\r\022\036 )Tj 0.321 Tw 0 -1.218 TD (\007\017\026\020\027\024\026 \r\r\017\007\031 \024\021\f\031\021\f\021\r\ \017\016 \036\020\024 \017\027\f\021\030\031\n\036\027\021\026\035\034\027\ \024\020\024 )Tj 0.069 Tw 0 -1.218 TD (\023\024\007\021\r\036\030\032\007\036\027\017\016, \026\035\020\024\030\ \017\021\n\031 \023\024\035\031\004\036\027\017\016 PRP \017)Tj /Span<>> BDC ( )Tj EMC (\f\023\024\f\024\002\031 )Tj 0.137 Tw T* (\036\036 \023\030\017\n\036\027\036\027\017\016 \(\n\036\f\021\027\024\036\ \027\026\027\036\f\036\027\017\036 \027\026)Tj /Span<>> BDC ( )Tj EMC (\030\026\027\036\r\031\033 \023\024)Tj 0 Tw (-)Tj 0.038 Tw T* (\r\036\030\b\027\024\f\021\034 \r)Tj /Span<>> BDC ( )Tj EMC (\r\017\007\036 \020\036\035\016 [3,4,6] \017\035\017 \017\027\255\036\022\ \006\017\024\027\027\024\036 \r\r\036)Tj 0 Tw (-)Tj T* (\007\036\027\017\036 \r)Tj /Span<>> BDC ( )Tj EMC (\f\021\036\027\022\017 \017)Tj /Span<>> BDC ( )Tj EMC (\007\027\024 \007\036\235\036\022\021\026 [5]\).)Tj 0.023 Tw T* (\203\026 \f\036\020\024\007\027\016\001\027\017\005 \007\036\027\034 \027\ \036\021 \004\036\021\022\017\b \030\036\022\024\n\036\027\007\026\006\017\ \005 \024)Tj /Span<>> BDC ( )Tj EMC (\004\026)Tj 0 Tw (-)Tj 0.325 Tw T* (\f\021\024\021\036 \017)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\017\024\007\017\004\027\024\f\021\017 \n\036\f\021\027\024\020\ \024 \023\030\017\n\036\027\036\027\017\016 PRP )Tj 0.209 Tw T* (\007\035\016 \007\024\f\021\017\032\036\027\017\016 \n\026\022\f\017\n\026\ \035\034\027\024\020\024 \220\235\235\036\022\021\026 \024\021 \023\030\024\ \r\036)Tj 0 Tw (-)Tj 0.183 Tw T* (\007\036\027\027\024\020\024 \035\036\004\036\027\017\016, \024\007\027\026\ \022\024 \027\036\024\002\b\024\007\017\n\024 \024\021\n\036\021\017\021\ \034, \004\021\024 )Tj 0.156 Tw T* [(\027\017 )0.6(\r)]TJ /Span<>> BDC ( )Tj EMC 2.28 0 Td [(\024\007\027\024\n )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC 4.299 0 Td [(\017\f\f\035\036\007\024\r\026\027\017\005 )0.6(\027\036\021 )0.6(\007\026\027\027\t\b )0.7(\024\002 )0.5(\031\f\023\036\b\036 )]TJ -0.012 Tw -6.579 -1.218 Td (\023\030\024\r\036\007\036\027\027\024\005 \n\026\027\017\023\031\035\016\ \006\017\017 \023\024\f\035\036 \024\007\027\024\022\030\026\021\027\024\ \020\024 \n\036\f\021)Tj 0 Tw (-)Tj 0.1 Tw T* (\027\024\020\024 \023\030\017\n\036\027\036\027\017\016 PRP, \026)Tj /Span<>> BDC ( )Tj EMC (\r \017\f\f\035\036\007\024\r\026\027\017\017 Boztug)Tj /Span<>> BDC ( )Tj EMC (C.Y. )Tj -0.024 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. [6] \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \n\017\027\017\n\026\035\034\027\024\020\024 \017\ \027\r\026\017\r\027\024\020\024 \r\n\036)Tj 0 Tw (-)Tj 0.131 Tw T* (\001\026\021\036\035\034\f\021\r\026 \r)Tj /Span<>> BDC ( )Tj EMC (\024\002\255\036\n\036 \022\033\030\036\021\026\032\026 \225\025\216 \f)Tj /Span<>> BDC ( )Tj EMC (\n\036\f\021\027\t\n \023\030\017)Tj 0 Tw (-)Tj 0.003 Tw T* (\n\036\027\036\027\017\036\n PRP \f\024\024\002\013\026\036\021\f\016 \024\ )Tj /Span<>> BDC ( )Tj EMC (\235\024\030\n\017\030\024\r\026\027\017\017 \026\002\f\006\036\f\f\026 \ )Tj -0.04 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\n\036\032\255\016\020\024\007\017\004\027\024\005 \024\002\035\026\f\021\ \017 \023\024\f\035\036 \r\r\036\007\036\027\017\016 \023\016\021\024\005\ \007\024\t )Tj 0 Tw T* (PRP \031)Tj /Span<>> BDC ( )Tj EMC (4 \(44,4%\) \017)Tj /Span<>> BDC ( )Tj EMC (9)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r.)Tj 0.2 Tw T* (\210\023\017\030\026\016\f\034 \027\026)Tj /Span<>> BDC ( )Tj EMC (\017\n\036\033\013\017\036\f\016 \007\026\027\027\t\036 \r)Tj /Span<>> BDC ( )Tj EMC (\023\030\036\007\f\021\026\r\035\036\027\027\t\b )Tj 0.044 Tw T* (\017\f\f\035\036\007\024\r\026\027\017\016\b, \n\024\032\027\024 \f\007\036\ \035\026\021\034 \026\022\035\033\004\036\027\017\036 \024\002 \024\021\ \f\031\021)Tj 0 Tw (-)Tj 0.174 Tw T* (\f\021\r\017\017 \036\007\017\027\024\005 \021\036\b\027\017\022\017 \024\ \023\036\030\026\021\017\r\027\024\020\024 \r\n\036\001\026\021\036\035\034\ \f\021\r\026 )Tj 0.402 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC [(\024\021\027\024\001\036\027\017\017 \024\023\030\036\007\036\035\036\027\ \017\016 \023\030\024\021\016\032\036\027\027\024\f\021\017 )0.5(\f\017\027\031\f\026 )]TJ -0.031 Tw T* (\023\030\017)Tj /Span<>> BDC ( )Tj EMC [(\017\027\021\030\026\024\023\036\030\026\006\017\024\027\027\024\005 \030\ \036\r\017\017\017, )0.5(\026)]TJ /Span<>> BDC ( )Tj EMC [(\021\026\022\032\036 )0.5(\036\020\024 \022\024\027\021\030\026)]TJ 0 Tw (-)Tj 0.063 Tw T* (\f\021\017\030\024\r\026\027\017\016. \210\007\027\026\022\024 \r\024 \r\ \f\036\b \023\031\002\035\017\022\026\006\017\016\b [3\2266] \023\030\017\ )Tj 0 Tw (-)Tj -0.01 Tw T* (\n\036\027\016\035\017 \036\007\017\027\031\033 \021\036\b\027\017\022\031\ \017\n\036\030\036\027\017\016 \024\002\255\036\n\026 \023\024\f\035\036\ \024\023\036)Tj 0 Tw (-)Tj T* (\030\026\006\017\024\027\027\024\020\024 \030\026\027\036\r\024\020\024 \ \007\036\235\036\022\021\026.)Tj 0.001 Tw T* (\200 \b\024\007\036 \023\030\024\r\036\007\036\027\027\024\020\024 \n\036\ \021\026\026\027\026\035\017\026 \007\024\022\026\026\027\024, \004\021\ \024 \f\030\024\022 )Tj 0.082 Tw T* [(\026\032\017\r\035\036\027\017\016 )0.5(\030\026\027\t \023\024\f\035\036 )0.5(\017\f\f\036\004\036\027\017\016 )0.5(\225\025\216 \023\030\017)]TJ /Span<>> BDC ( )Tj EMC (\n\036\f\021\027\024\n )Tj 0.271 Tw T* [(\017\f\023\024\035\034\024\r\026\027\017\017 PRP \f\021\026\021\017\f\021\ \017\004\036\f\022\017 )0.5(\027\026\004\017\n\024 \f\027\017\032\026)]TJ 0 Tw (-)Tj 0.119 Tw T* [(\036\021\f\016 )0.5(\(\030\026\027\017\006\026 )0.6(\f\030\036\007\027\017\b)]TJ /Span<>> BDC ( )Tj EMC 9.946 0 Td (=)Tj /Span<>> BDC ( )Tj EMC 0.851 0 Td [(19,01, )0.5(95% )0.6(\212\236: )0.5(6,40\22631,63, )]TJ /T1_1 1 Tf 0 Tw -10.798 -1.218 Td (p)Tj /T1_0 1 Tf 0.012 Tw /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (0,000001\), \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\n \027\026\002\035\033\007\026\036\021\f\016 \f\021\024\005\ \022\026\016 \026\r\017\f\017)Tj 0 Tw (-)Tj -0.042 Tw T* (\n\024\f\021\034 \f\021\026\021\017\f\021\017\004\036\f\022\017 \027\026\ \004\017\n\024\020\024 \031\n\036\027\034\001\036\027\017\016 \f\030\036\ \007\027\036\020\024 )Tj 0.032 Tw T* (\024\002\255\036\n\026 \023\024\f\035\036\024\023\036\030\026\006\017\024\ \027\027\024\005 \030\026\027\t, \027\026\004\017\027\026\016 \f)Tj /Span<>> BDC ( )Tj EMC (10-\b)Tj /Span<>> BDC ( )Tj EMC (\f\031)Tj 0 Tw (-)Tj -0.095 Tw T* (\021\024\022 \023\024\f\035\036 \r\n\036\001\026\021\036\035\034\f\021\r\ \026 \(\030\026\027\017\006\026 \f\030\036\007\027\017\b)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (3,68, 95% )Tj -0.025 Tw T* (\212\236: 3,29\2264,06, )Tj /T1_1 1 Tf 0 Tw (p)Tj /T1_0 1 Tf -0.025 Tw /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (0,00001\) \022)Tj /Span<>> BDC ( )Tj EMC (\031\r\036\035\017\004\036\027\017\033 \030\026\030\t\r\026 \023\024)Tj 0 Tw (-)Tj -0.035 Tw T* (\022\026\026\021\036\035\036\005 \022)Tj /Span<>> BDC ( )Tj EMC (20-\n \f\031\021\022\026\n \(\030\026\027\017\006\026 \f\030\036\007\027\ \017\b)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (6,62, 95% )Tj 0.059 Tw T* (\212\236: 6,14\2267,10, )Tj /T1_1 1 Tf 0 Tw (p)Tj /T1_0 1 Tf 0.059 Tw /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (0,00001\). \215\030\017)Tj /Span<>> BDC ( )Tj EMC [(\220\021\024\n, M)-24(ohammadi)]TJ /Span<>> BDC ( )Tj EMC (S. )Tj -0.013 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC 0.737 0 Td [(\f\024\026\r\021. )0.5([3] )0.5(\031\022\026\t\r\026\033\021 )0.6(\027\026)]TJ /Span<>> BDC ( )Tj EMC 10.046 0 Td [(\026\r\017\f\017\n\024\f\021\034 )0.6(\024\002\255\036\n\026 )0.5(\023\024\f\035\036)]TJ 0 Tw (-)Tj 0.038 Tw -10.783 -1.218 Td (\024\023\036\030\026\006\017\024\027\027\024\005 \030\026\027\t \023\024\ )Tj /Span<>> BDC ( )Tj EMC (\024\021\027\024\001\036\027\017\033 \022)Tj /Span<>> BDC ( )Tj EMC (\021\036\n\023\031 \026\032\017\r\035\036)Tj 0 Tw (-)Tj 0.128 Tw T* (\027\017\016, \031\021\r\036\030\032\007\026\016, \004\021\024 \030\026\027\ \t \024\002\255\036\n\024\n \002\024\035\036\036 42)Tj /Span<>> BDC ( )Tj EMC (\f\n)Tj 0 Tw 5.83 0 0 5.83 273.0263 107.0818 Tm (3)Tj 0.128 Tw 10 0 0 10 275.9413 103.7518 Tm ( \026)Tj 0 Tw (-)Tj 0.016 Tw -20.508 -1.218 Td [(\032\017\r\026\033\021 )0.5(\n\036\007\035\036\027\027\036\036 )0.5(\023\024)]TJ /Span<>> BDC ( )Tj EMC 9.346 0 Td [(\f\030\026\r\027\036\027\017\033 )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC [(\030\026\027\026\n\017 )0.5(\n\036\027\034\001\036\020\024 )]TJ 0.07 Tw -9.346 -1.218 Td (\024\002\255\036\n\026. Gohar)Tj /Span<>> BDC ( )Tj EMC (M.M. \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. [5] \024\007\027\017\n \017)Tj /Span<>> BDC ( )Tj EMC (\022\030\017\021\036\030\017\036\r )Tj 0.528 Tw 23.244 64.543 Td (\017\f\022\035\033\004\036\027\017\016 \023\030\024\r\036\007\036\027\027\ \024\020\024 \017\f\f\035\036\007\024\r\026\027\017\016 \024\002\024\027\ \026)Tj 0 Tw (-)Tj 0.321 Tw 0 -1.218 TD (\004\026\035\017 \027\026\035\017\004\017\036 \023\024\f\035\036\024\023\ \036\030\026\006\017\024\027\027\024\020\024 \007\036\235\036\022\021\026\ \002\024\035\036\036 )Tj 0.164 Tw 0 -1.218 TD (35)Tj /Span<>> BDC ( )Tj EMC (\f\n)Tj 0 Tw 5.83 0 0 5.83 327.3607 703.8039 Tm (3)Tj 0.164 Tw 10 0 0 10 330.2757 700.4739 Tm (. \203\036\f\n\024\021\030\016 \027\026)Tj /Span<>> BDC ( )Tj EMC (\021\024, \004\021\024 \r\024)Tj /Span<>> BDC ( )Tj EMC (\r\f\036\b \017\f\f\035\036\007\024\r\026\027\017\016\b )Tj 0.082 Tw -2.697 -1.218 Td ([3\2266] \031\023\024\021\030\036\002\035\016\036\021\f\016 \021\036\030\ \n\017\027 \253\026\032\017\r\035\036\027\017\036\273, \027\017 \r)Tj /Span<>> BDC ( )Tj EMC (\024\007)Tj 0 Tw (-)Tj 0.201 Tw T* (\027\024\005 \017)Tj /Span<>> BDC ( )Tj EMC (\023\031\002\035\017\022\026\006\017\005 \027\036 \030\026\f\022\030\t\r\ \026\036\021\f\016 \036\020\024 \027\026\004\036\027\017\036. )Tj 0.087 Tw T* [(Spyr)-37(id)42(ak)-16(is)]TJ /Span<>> BDC ( )Tj EMC 4.412 0 Td [(\204. )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC 2.12 0 Td [(\f\024\026\r\021. )0.6([4] )0.6(\r)]TJ /Span<>> BDC ( )Tj EMC 5.222 0 Td [(\f\r\024\036\005 )0.6(\023\031\002\035\017\022\026\006\017\017 )0.6(\r\r\036\035\017 )]TJ 0.173 Tw -11.754 -1.218 Td (\023\024\027\016\021\017\036 \017\027\007\036\022\f\026 \026\032\017\r\035\ \036\027\017\016, \022\024\021\024\030\t\005 \023\030\036\007\f\021\026\r\ \035\016\035 )Tj 0.183 Tw 0 -1.218 TD (\f\024\002\024\005 \022\024\035\017\004\036\f\021\r\024 \007\027\036\005\ , \027\036\024\002\b\024\007\017\n\t\b \007\035\016 \026\023\024\035\027\ \036)Tj 0 Tw (-)Tj 0.056 Tw 0 -1.218 TD (\027\017\016 \022\026\032\007\024\020\024 1)Tj /Span<>> BDC ( )Tj EMC (\f\n)Tj 0 Tw 5.83 0 0 5.83 376.525 630.7358 Tm (3)Tj 0.056 Tw 10 0 0 10 379.44 627.4058 Tm ( \024\002\255\036\n\026 \023\024\035\024\f\021\017, \017)Tj /Span<>> BDC ( )Tj EMC (\030\026\r\027\016\035\f\016 \024\021\027\024)Tj 0 Tw (-)Tj 0.1 Tw -7.613 -1.218 Td (\001\036\027\017\033 \r\030\036\n\036\027\017 \026\032\017\r\035\036\027\ \017\016 \027\026)Tj /Span<>> BDC ( )Tj EMC (\036\007\017\027\017\006\031 \024\002\255\036\n\026 \023\024)Tj 0 Tw (-)Tj 0.114 Tw T* (\035\024\f\021\017 \(\007\027\017/\f\n)Tj 0 Tw 5.83 0 0 5.83 363.3306 606.3798 Tm (3)Tj 0.114 Tw 10 0 0 10 366.2456 603.0498 Tm (\). \200)Tj /Span<>> BDC ( )Tj EMC (\007\026\035\034\027\036\005\001\036\n Boztug)Tj /Span<>> BDC ( )Tj EMC (C.Y. \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. )Tj 0.183 Tw -6.294 -1.218 Td ([6] \017\f\023\024\035\034\024\r\026\035\017 \026\027\026\035\024\020\017\ \004\027\t\005 \022\030\017\021\036\030\017\005 \007\035\016 \024\006\036\ \027)Tj 0 Tw (-)Tj 0.253 Tw T* [(\022\017 \f\022\024\030\024\f\021\017 \026\032\017\r\035\036\027\017\016\ )0.5(\023\024\f\035\036\024\023\036\030\026\006\017\024\027\027\024\005 )0.5(\030\026\027\t )]TJ 0.262 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC 0.968 0 Td [(\020\030\031\023\023\026\b )0.5(\f\030\026\r\027\036\027\017\016, )0.6(\023\024\035\031\004\017\r )0.5(\f\035\036\007\031\033\013\017\036 )0.6(\007\026\027\027\t\036: )]TJ 0.14 Tw -0.968 -1.218 Td (1,8)Tj /Span<>> BDC ( )Tj EMC (\007\027\036\005/\f\n)Tj 0 Tw 5.83 0 0 5.83 353.3037 557.6678 Tm (3)Tj 0.14 Tw /Span<>> BDC 10 0 0 10 356.2187 554.3378 Tm ( )Tj EMC (\227 \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \n\036\f\021\027\024\020\024 \023\030\017\n\036\ \027\036\027\017\016 PRP )Tj 0.073 Tw -5.291 -1.218 Td (\r)Tj /Span<>> BDC ( )Tj EMC (\f\024\004\036\021\026\027\017\017 \f)Tj /Span<>> BDC ( )Tj EMC (\017\f\f\036\004\036\027\017\036\n \225\025\216 \f)Tj /Span<>> BDC ( )Tj EMC (\024\021\022\030\t\021\t\n \f\023\024\f\024\002\024\n )Tj 0.041 Tw T* (\r\036\007\036\027\017\016 \030\026\027\t \017)Tj /Span<>> BDC ( )Tj EMC (3,8)Tj /Span<>> BDC ( )Tj EMC (\007\027\016/\f\n)Tj 0 Tw 5.83 0 0 5.83 415.5406 533.3118 Tm (3)Tj 0.041 Tw /Span<>> BDC 10 0 0 10 418.4556 529.9818 Tm ( )Tj EMC (\227 \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \017\024\035\017\030\024\r\026\027)Tj 0 Tw (-)Tj 0.2 Tw -11.515 -1.218 Td (\027\024\020\024 \017\f\f\036\004\036\027\017\016 \225\025\216 \f)Tj /Span<>> BDC ( )Tj EMC (\024\021\022\030\t\021\t\n \f\023\024\f\024\002\024\n \r\036\007\036\027\ \017\016 )Tj 0.367 Tw T* (\030\026\027\t \007\035\016 \035\036\004\036\027\017\016 \b\030\024\027\017\ \004\036\f\022\024\020\024 \r\024\f\023\026\035\036\027\017\016 \225\025\ \216, )Tj 0 Tw T* (\f\024\024\021\r\036\021\f\021\r\036\027\027\024.)Tj -0.069 Tw T* (\203\036\024\002\b\024\007\017\n\024 \024\021\n\036\021\017\021\034, \004\ \021\024 \r)Tj /Span<>> BDC ( )Tj EMC [(\023\031\002\035\017\022\026\006\017\016\b Spyr)-37(id)42(ak)-16(is)]TJ /Span<>> BDC ( )Tj EMC (\204. )Tj -0.046 Tw T* ([4] \017)Tj /Span<>> BDC ( )Tj EMC (Gohar M.M. [5] \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. \002\t\035\017 \023\030\024\007\036\n\024\027\f\021\030\ \017\030\024\r\026)Tj 0 Tw (-)Tj 0.032 Tw T* [(\027\t )0.5(\007\026\027\027\t\036 )0.5(\024\002 )0.5(\031\f\022\024\030\036\027\017\017 )0.6(\021\036\n\023\024\r )0.5(\026\032\017\r\035\036\027\017\016 )0.6(\023\030\017)]TJ /Span<>> BDC ( )Tj EMC 20.803 0 Td (\017\f)Tj 0 Tw (-)Tj -0.003 Tw -20.803 -1.218 Td (\023\024\035\034\024\r\026\027\017\017 PRP \027\026)Tj /Span<>> BDC ( )Tj EMC (30\22640% \023\024)Tj /Span<>> BDC ( )Tj EMC (\f\030\026\r\027\036\027\017\033 \f)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\024\005 )Tj 0.099 Tw T* (\022\024\027\021\030\024\035\016, \026)Tj /Span<>> BDC ( )Tj EMC [(M)-24(ohammadi S. \017)]TJ /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. [3] \f\024\024\002\013\026\035\017 \024\002 )Tj -0.012 Tw T* (\031\f\022\024\030\036\027\017\017 \026\032\017\r\035\036\027\017\016 \r\ )Tj /Span<>> BDC ( )Tj EMC (37,2 \030\026\026, \004\021\024 \f\026\n\017 \017\f\f\035\036\007\024)Tj 0 Tw (-)Tj -0.003 Tw T* (\r\026\021\036\035\017 \f\r\016\t\r\026\035\017 \f)Tj /Span<>> BDC ( )Tj EMC (\026\022\021\017\r\017\026\006\017\036\005 \026\027\020\017\024\020\036\ \027\036\026 \r)Tj /Span<>> BDC ( )Tj EMC (\024\027\036 )Tj 0.203 Tw T* (\023\024\r\030\036\032\007\036\027\017\016 \r\r\017\007\031 \r\t\f\r\024\ \002\024\032\007\026\036\n\024\020\024 \274-\020\030\026\027\031\035\026\ \n\017 )Tj 0.19 Tw T* (\021\030\024\n\002\024\006\017\021\024\r \f\024\f\031\007\017\f\021\024\020\ \024 \220\027\007\024\021\036\035\017\026\035\034\027\024\020\024 \235\026\ \022\021\024\030\026 )Tj 0.076 Tw T* [(\030\024\f\021\026, )0.5(\026)]TJ /Span<>> BDC ( )Tj EMC 3.547 0 Td [(\021\026\022\032\036 )0.5(\n\036\021\026\035\035\024\023\030\024\021\036\026\t)]TJ /Span<>> BDC ( )Tj EMC 10.233 0 Td [(\227 )0.5(4, )0.5(\022\024\021\024\030\t\005 )0.6(\024\021\027\024)]TJ 0 Tw (-)Tj 0.192 Tw -13.78 -1.218 Td (\f\017\021\f\016 \022)Tj /Span<>> BDC ( )Tj EMC (\f\021\030\031\022\021\031\030\027\t\n \n\026\021\030\017\022\f\027\t\n \ \002\036\035\022\026\n, \004\021\024 \002\t\035\024 )Tj 0.434 Tw T* [(\023\024\007\021\r\036\030\032\007\036\027\024 \023\031\021\036\n )0.5(\017\027\006\017\017\024\027\027\024\005 \002\017\024\023\f\017\017 )0.5(\030\026\027\t )]TJ 0.224 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\023\024\f\035\036\007\031\033\013\036\005 \017\n\n\031\027\024\020\017\f\ \021\024\b\017\n\017\004\036\f\022\024\005 \r\036\030\017\235\017\022\026\ )Tj 0 Tw (-)Tj -0.045 Tw T* (\006\017\036\005 \220\022\f\023\030\036\f\f\017\017 \220\027\007\024\021\ \036\035\017\026\035\034\027\024\020\024 \235\026\022\021\024\030\026 \(\ CD)Tj /Span<>> BDC ( )Tj EMC (\227 34\) )Tj 0 Tw T* ([3].)Tj 0.185 Tw T* [(M)-24(ohammadi S. \017)]TJ /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. [3] \024\021\n\036\004\026\035\017 \023\030\016\n\031\033\ \f\r\016\034 )Tj 0.093 Tw T* (\n\036\032\007\031 \017\001\036\n\017\026\006\017\036\005 \030\026\027\t\ \r\r\017\007\031 \023\024\r\030\036\032\007\036\027\017\016 \022\024\032\ \017 )Tj 0.109 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC [(\022\030\024\r\036\027\024\f\027\t\b )0.5(\f\024\f\031\007\024\r \r)]TJ /Span<>> BDC ( )Tj EMC 11.069 0 Td [(\b\024\007\036 \024\023\036\030\026\006\017\017, )0.5(\023\030\017\f\024\036\007\017)]TJ 0 Tw (-)Tj 0.053 Tw -11.069 -1.218 Td (\027\036\027\017\036\n \017\027\235\036\022\006\017\017 \017)Tj /Span<>> BDC ( )Tj EMC (\r\024\027\017\022\027\024\r\036\027\017\036\n \002\024\035\017 \r)Tj /Span<>> BDC ( )Tj EMC (\024\002\035\026\f\021\017 )Tj 0.396 Tw T* (\b\017\030\031\030\020\017\004\036\f\022\024\020\024 \r\n\036\001\026\021\ \036\035\034\f\021\r\026. \202\r\021\024\030\t \031\021\r\036\030\032\007\ \026)Tj 0 Tw (-)Tj 0.222 Tw T* (\035\017, \004\021\024 \024\002\036\f\023\036\004\036\027\017\036 \007\024\ \f\021\026\021\024\004\027\024\005 \023\036\030\235\031\017\017 \021\022\ \026\027\036\005 )Tj 0.141 Tw T* (\026)Tj /Span<>> BDC ( )Tj EMC (\f\004\036\021 \023\030\024\007\031\022\021\017\r\027\024\020\024 \026\027\ \020\017\024\020\036\027\036\026 \n\024\032\036\021 \023\030\017\r\036\f\ \021\017 )Tj 0.164 Tw T* (\022)Tj /Span<>> BDC ( )Tj EMC (\031\n\036\027\034\001\036\027\017\033 \017\035\017 \017\f\004\036\027\024\ \r\036\027\017\033 \002\024\035\017 \r)Tj /Span<>> BDC ( )Tj EMC (\n\036\f\021\036 \030\026)Tj 0 Tw (-)Tj 0.196 Tw T* [(\027\036\r\024\020\024 )0.5(\007\036\235\036\022\021\026. )0.6(\200)]TJ /Span<>> BDC ( )Tj EMC 8.348 0 Td [(\b\024\007\036 )0.5(\023\030\024\r\036\007\036\027\027\024\020\024 )0.6(\n\036\021\026\026\027\026\035\017\026 )]TJ 0.161 Tw -8.348 -1.218 Td (\007\024\022\026\026\027\024 \f\021\026\021\017\f\021\017\004\036\f\022\ \017 \027\026\004\017\n\024\036 \031\n\036\027\034\001\036\027\017\036 \ \023\030\024)Tj 0 Tw (-)Tj 0.187 Tw T* (\007\024\035\032\017\021\036\035\034\027\024\f\021\017 \002\024\035\036\r\ \024\020\024 \f\017\027\007\030\024\n\026 \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \n\036\f\021)Tj 0 Tw (-)Tj 0.105 Tw T* (\027\024\020\024 \023\030\017\n\036\027\036\027\017\016 PRP \f)Tj /Span<>> BDC ( )Tj EMC (\017\f\f\036\004\036\027\017\036\n \225\025\216 \f)Tj /Span<>> BDC ( )Tj EMC (\024\021\022\030\t\021\t\n )Tj 0.21 Tw T* (\f\023\024\f\024\002\024\n \r\036\007\036\027\017\016 \030\026\027\t \(\030\ \026\027\017\006\026 \f\030\036\007\027\017\b)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (10,46, )Tj -0.009 Tw T* (95% \212\236: 2,20\22618,72, )Tj /T1_1 1 Tf 0 Tw (p)Tj /T1_0 1 Tf -0.009 Tw /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (0,00001\). \215\030\017)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\n \f\027\017\032\036\027\017\036 )Tj 0.136 Tw T* [(\002\024\035\017 )0.5(\024\021\n\036\004\036\027\024 )0.6(\027\036 )0.5(\021\024\035\034\022\024 )0.5(\031)]TJ /Span<>> BDC ( )Tj EMC 11.886 0 Td [(\023\026\006\017\036\027\021\024\r )0.6(\023\024\f\035\036 )0.5(\024\023\036\030\026)]TJ 0 Tw (-)Tj 0.127 Tw -11.886 -1.218 Td (\006\017\017 \023\024)Tj /Span<>> BDC ( )Tj EMC (\023\024\r\024\007\031 \b\030\024\027\017\004\036\f\022\024\020\024 \r\024\ \f\023\026\035\036\027\017\016 \225\025\216 [3\2266], )Tj 0.129 Tw T* (\027\024 \017)Tj /Span<>> BDC ( )Tj EMC (\031 \023\026\006\017\036\027\021\024\r, \024\023\036\030\017\030\024\r\026\ \027\027\t\b \023\024)Tj /Span<>> BDC ( )Tj EMC (\023\024\r\024\007\031 \024\f\021\030\024)Tj 0 Tw (-)Tj 0.099 Tw T* (\020\024 \r\024\f\023\026\035\036\027\017\016 \225\025\216 \r)Tj /Span<>> BDC ( )Tj EMC (\f\021\026\007\017\017 \026\002\f\006\036\007\017\030\024\r\026\027\017\016\ [9\22610] )Tj 0 Tw T* (\()Tj /T1_1 1 Tf (p)Tj /T1_0 1 Tf -0.014 Tw /Span<>> BDC ( )Tj EMC 1.067 0 Td (<)Tj /Span<>> BDC ( )Tj EMC 0.719 0 Td [(0,00001\). )0.5(\200)]TJ /Span<>> BDC ( )Tj EMC [(\f\r\024\033 )0.5(\024\004\036\030\036\007\034, )0.5(Gohar M.M. )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 16.317 0 Td [(\f\024\026\r\021. )0.5([5] )]TJ 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0 Tw 7.5 0 0 7.5 70.8661 759.8869 Tm [(\007\003\032)50(\n\n\217\n)-21(\035\030\002)]TJ 53.418 0 Td [(MET)30(A)-41(-)-41.9(ANAL)30(Y)30(SIS)]TJ -53.418 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 2)69(4, \023\0224, 202)23(5)]TJ 43.013 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 2)69(4, \023\0224, 202)23(5)]TJ /T1_3 1 Tf 25 0 0 25 20.8778 56.0378 Tm (148)Tj ET endstream endobj 1430 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\007\016\b)-10(\026\215\025\016 \222\201\021\024\016\215\016\215\021\016 \001\200)-20(\026)11(\025\222\t\001\213\024\220, \025\235\025\202)10(\001\232\016\215\215\025\207 \026\201\025\024\235\025\212\021\026)11(\001\024\021, )]TJ 0 -1 TD [(\017\001\017 \b\222\025\b\025\235 \200\t\200\f\020\016\215\021\004 \201\016\ \213)21.1(\200\t\214)21(\026)11(\001\026)11(\025\r \025\222\016\201\001\026\021\r\215\025\202)10(\025 \t\016\f\016\215\021\004 )]TJ T* [(\201\025\215\021\f\016\b\017)10.1(\025\202)10(\025 \r\025\b\222\001\t\016\215\021\004 \242\222\021\026)11(\016\t\021\001\t\214\215\025\202)10.1(\025 \017)10(\025\222\f\021\017)10(\025\r\025\202)10(\025 \025\211\001 )]TJ T* [(\(\b\021\b)-10(\026)11(\016\024\001\026\021\f\016\b\017\021\207 \025\235\213\025\201 \t\021\026\ )11(\016\201\001\026)-20(\200\201\220 \021\022\024\016\026)11(\001\001\215\001\t\021\213\))]TJ 41.398 3 Td (A platelet rich plasma for pilonidal sinus disease )Tj 4.085 -1 Td [(\(s)10(y)10(stematic r)31(e)11(vie)11(w and meta-analy)10(sis\))]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 10 0 0 10 42.5197 724.8299 Tm (p)Tj /T1_2 1 Tf 0.01 Tc -0.018 Tw /Span<>> BDC 0.488 0 Td ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (0,00001\). \215\030\017)Tj /Span<>> BDC ( )Tj EMC [(\026\027\026\035\017\036 \r\t\016\r\035\036\027 \r\t\f\024\022\017\005 \ \031\030\024\r\036\027\034)10( )]TJ 0 Tw -0.488 -1.218 Td (\020\036\021\036\030\024\020\036\027\027\024\f\021\017, \020\007\036 I)Tj 0 Tc 5.83 0 0 5.83 131.9883 715.9819 Tm (2)Tj 0.01 Tc /Span<>> BDC 10 0 0 10 134.9616 712.6519 Tm ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (98% \(\217\017\f.)Tj /Span<>> BDC ( )Tj EMC (13\).)Tj /T1_3 1 Tf 0 Tc -9.244 -2.436 Td (\017\n\006\004\b\t\201\r\b\t\235 \214\r\003\004\004\b\004\f\t\213\004)Tj /T1_2 1 Tf 0.574 Tw 0 -1.218 TD [(\210\020\030\026\027\017\004\036\027\017\016\n\017 )0.6(\023\030\024\r\036\007\201\027\027\024\020\024 )0.5(\n\036\021\026\026\027\026\035\017\026 )0.5(\016\r\035\016)]TJ 0 Tw (-)Tj 0.136 Tw T* [(\035\017\f\034: )0.5(\024\021\f\031\021\f\021\r\017\036 )0.6(\017\027\f\021\030\031\n\036\027\021\026\035\034\027\024\020\024 )0.6(\023\024\007\021\r\036\030\032\007\036\027\017\016 )]TJ 0.062 Tw T* (\031\f\021\026\027\024\r\035\036\027\027\024\020\024 \r)Tj /Span<>> BDC ( )Tj EMC (\b\024\007\036 \024\f\n\024\021\030\026 \007\017\026\020\027\024\026; \030\ \026\035\017\004\027\026\016 )Tj 0.18 Tw 0 -1.218 TD [(\n\036\021\024\007\017\022\026 )0.5(\023\024\035\031\004\036\027\017\016 )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC 9.969 0 Td [(\023\030\017\n\036\027\036\027\017\016 )0.6(PRP; )0.5(\024\021\f\031\021\f\021\r\017\036 )]TJ 0.245 Tw -9.969 -1.218 Td (\022\024\027\021\030\024\035\016 \022\024\027\006\036\027\021\030\026\006\ \017\017 \021\030\024\n\002\024\006\017\021\024\r \r)Tj /Span<>> BDC ( )Tj EMC (PRP \r)Tj /Span<>> BDC ( )Tj EMC (50% )Tj 0.302 Tw T* [(\017\f\f\035\036\007\024\r\026\027\017\016\b )0.5([4\2265]; \027\017\022\024\036 \022\026\004\036\f\021\r\024 \017\f\f\035\ \036\007\024\r\026)]TJ 0 Tw (-)Tj 0.35 Tw 0 -1.218 TD (\027\017\005, \r\022\035\033\004\036\027\027\t\b \r)Tj /Span<>> BDC ( )Tj EMC (\n\036\021\026\026\027\026\035\017, \024\002\031\f\035\026\r\035\017\r\026\ \033\013\017\b )Tj 0.353 Tw 0 -1.218 TD (\r\t\f\024\022\017\005 \030\017\f\022 \f\n\036\013\036\027\017\016 \023\024\ \035\031\004\036\027\027\t\b \030\036\031\035\034\021\026\021\024\r; )Tj 0.156 Tw 0 -1.218 TD [(\024\021\f\031\021\f\021\r\017\036 )0.6(\f\021\026\027\007\026\030\021\017\017\030\024\r\026\027\027\024\020\024\ )0.6(\n\036\021\024\007\026 )0.5(\024\023\030\036\007\036\035\036)]TJ 0 Tw (-)Tj 0.159 Tw T* (\027\017\016 \023\030\024\021\016\032\036\027\027\024\f\021\017 \f\017\027\ \031\f\026 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\017\027\021\030\026\024\023\036\030\026\006\017\024\027\027\024\005 )Tj 0.046 Tw T* (\030\036\r\017\017\017; \022\024\027\021\030\026\f\021\017\030\024\r\026\ \027\017\036 \225\025\216 \r)Tj /Span<>> BDC ( )Tj EMC (50% \017\f\f\035\036\007\024\r\026\027\017)Tj 0 Tw (-)Tj 0.181 Tw 0 -1.218 TD (\016\b [4\2265]; \024\021\f\031\021\f\021\r\017\036 \024\023\030\036\007\ \036\035\036\027\017\016 \023\024\027\016\021\017\016 \253\026\032\017\r\ )Tj 0 Tw (-)Tj 0.248 Tw 0 -1.218 TD (\035\036\027\017\036\273 \r)Tj /Span<>> BDC ( )Tj EMC (100% \017\f\f\035\036\007\024\r\026\027\017\016\b [3\2266]; \024\002\255\ \036\022\021\017\r\027\026\016 )Tj -0.038 Tw 0 -1.218 TD (\024\006\036\027\022\026 \026\027\020\017\024\020\036\027\036\026 \r)Tj /Span<>> BDC ( )Tj EMC (\023\024\f\035\036\024\023\036\030\026\006\017\024\027\027\024\005 \030\026\ \027\036 \023\031\021\036\n )Tj 0.093 Tw 0 -1.218 TD (\017\027\006\017\017\024\027\027\024\005 \002\017\024\023\f\017\017 \f)Tj /Span<>> BDC ( )Tj EMC (\023\024\f\035\036\007\031\033\013\036\005 \017\n\n\031\027\024\020\017\f\ \021\024)Tj 0 Tw (-)Tj 0.062 Tw 0 -1.218 TD (\b\017\n\017\004\036\f\022\024\005 \r\036\030\017\235\017\022\026\006\017\ \036\005 \220\022\f\023\030\036\f\f\017\017 \220\027\007\024\021\036\035\ \017\026\035\034)Tj 0 Tw (-)Tj 0.055 Tw 0 -1.218 TD (\027\024\020\024 \235\026\022\021\024\030\026 \(CD)Tj /Span<>> BDC ( )Tj EMC (\227 34\) \035\017\001\034 \r)Tj /Span<>> BDC ( )Tj EMC (1 \017\f\f\035\036\007\024\r\026\027\017\017 [3]; )Tj 0.113 Tw T* (\024\021\f\031\021\f\021\r\017\036 \024\023\030\036\007\036\035\036\027\017\ \016 \021\036\030\n\017\027\026 \253\030\036\006\017\007\017\r\273 \r)Tj /Span<>> BDC ( )Tj EMC (100% )Tj 0.059 Tw T* (\017\f\f\035\036\007\024\r\026\027\017\016\b [3\2266]; \024\023\017\f\026\ \027\017\036 \030\026\r\017\021\017\016 \030\036\006\017\007\017\r\024\r\ )Tj -0.044 Tw T* (\035\017\001\034 \r)Tj /Span<>> BDC ( )Tj EMC (1 \017\f\f\035\036\007\024\r\026\027\017\017 [6]; \030\026\035\017\004\027\ \t\005 \f\030\024\022 \027\026\002\035\033\007\036)Tj 0 Tw (-)Tj 0.085 Tw 0 -1.218 TD [(\027\017\016 )0.5(\026)]TJ /Span<>> BDC ( )Tj EMC 3.026 0 Td [(\023\026\006\017\036\027\021\026\n\017 )0.5(\r\024 )0.5(\r\022\035\033\004\036\027\027\t\b )0.6(\r)]TJ /Span<>> BDC ( )Tj EMC 12.722 0 Td [(\n\036\021\026\026\027\026\035\017 )0.6(\017\f)]TJ 0 Tw (-)Tj 0.009 Tw -15.748 -1.218 Td (\f\035\036\007\024\r\026\027\017\016\b)Tj /Span<>> BDC ( )Tj EMC (\227 \024\021 30 [4] \007\024)Tj /Span<>> BDC ( )Tj EMC (183 [6] \007\027\036\005; \r\022\035\033\004\036\027\017\036 )Tj 0.178 Tw 0 -1.218 TD (\r)Tj /Span<>> BDC ( )Tj EMC (\026\027\026\035\017 \023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\030\036\006\017\007\017\r\024\n \225\025\216 [5]; \r\t\f\024\022\017\005\ )Tj 0 Tw 0 -1.218 TD (\031\030\024\r\036\027\034 \020\036\021\036\030\024\020\036\027\027\024\f\ \021\017 \007\026\027\027\t\b.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 42.5895 359.4898 Tm [(\037\036)10(\032\223\212\226\034\022\031\034)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf 0 Tc 0.137 Tw 10 0 0 10 42.5197 335.1338 Tm [(\203\036\f\n\024\021\030\016 )0.5(\027\026)]TJ /Span<>> BDC ( )Tj EMC 5.653 0 Td [(\f\031\013\036\f\021\r\024\r\026\027\017\036 )0.6(\n\027\024\032\036\f\021\r\026 )0.5(\021\036\024\030\017\005 )0.5(\r\024)]TJ 0 Tw (-)Tj 0.398 Tw -5.653 -1.218 Td (\027\017\022\027\024\r\036\027\017\016 \225\025\216 [15], \r\f\036 \f\023\ \024\f\024\002\t \030\026\007\017\022\026\035\034\027\024\020\024 )Tj 0.361 Tw 0 -1.218 TD (\035\036\004\036\027\017\016 \027\026\023\030\026\r\035\036\027\t \027\026\ )Tj /Span<>> BDC ( )Tj EMC (\031\007\026\035\036\027\017\036 \220\021\017\024\035\024\020\017\004\036\ \f\022\024\005 )Tj 0.255 Tw 23.244 41.405 Td (\023\030\017\004\017\027\t \007\026\027\027\024\020\024 \026\002\024\035\ \036\r\026\027\017\016 \022\026\022 \017\f\021\024\004\027\017\022\026 \r\ \024\f)Tj 0 Tw (-)Tj 0.141 Tw 0 -1.218 TD (\023\026\035\036\027\017\016, \026)Tj /Span<>> BDC ( )Tj EMC (\017\n\036\027\027\024, \031\022\024\020\024 \022\026\027\026\035\026 \r\ )Tj /Span<>> BDC ( )Tj EMC (\n\036\032\255\016\020\024\007\017\004\027\024\005 )Tj 0.272 Tw 0 -1.218 TD (\024\002\035\026\f\021\017, \r\t\f\021\035\026\027\027\024\020\024 \220\023\ \017\021\036\035\017\036\n, \f\024\007\036\030\032\026\013\036\020\024 \r\ \024)Tj 0 Tw (-)Tj 0.059 Tw 0 -1.218 TD (\035\024\f\016\027\t\036 \035\031\022\024\r\017\006\t, \f\026\035\034\027\ \t\036 \032\036\035\036\t, \022\024\021\024\030\t\005 \024\021\022\030\t\ )Tj 0 Tw (-)Tj 0.165 Tw 0 -1.218 TD (\r\026\036\021\f\016 \027\026)Tj /Span<>> BDC ( )Tj EMC (\022\024\032\036 \024\007\027\017\n \017\035\017 \027\036\f\022\024\035\034\ \022\017\n\017 \021\024\004\036\004\027\t\n\017 )Tj 0.143 Tw 0 -1.218 TD [(\(\023\036\030\r\017\004\027\t\n\017\) \024\021\r\036\030\f\021\017\016\n\ \017 )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC (\017\n\036\027\036\027\027\t\n\017 \021\022\026\027\016\n\017 )Tj 0 Tw 0 -1.218 TD (\r\024\022\030\031\020 \b\024\007\026 [1].)Tj 0.097 Tw 0 -1.218 TD [(\200\t\f\024\022\026\016 )0.5(\004\026\f\021\024\021\026 \030\036\006\017\007\017\r\024\r, )0.5(\024\f\035\024\032\027\036\027\017\005 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC (\r\017\007\036 \017\027)Tj 0 Tw (-)Tj 0.495 Tw T* (\235\017\006\017\030\024\r\026\027\017\016 \023\024\f\035\036\024\023\036\ \030\026\006\017\024\027\027\024\005 \030\026\027\t, \026)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\032\036 )Tj 0.29 Tw T* (\007\035\017\021\036\035\034\027\024\020\024 \f\030\024\022\026 \r\030\036\ \n\036\027\027\024\005 \027\036\021\030\031\007\024\f\023\024\f\024\002\027\ \024\f\021\017 )Tj 0.147 Tw T* (\r\t\027\031\032\007\026\033\021 \r\030\026\004\036\005-\022\024\035\024\ \023\030\024\022\021\024\035\024\020\024\r \017\f\022\026\021\034 \017\007\ \036\026\035\034)Tj 0 Tw (-)Tj 0.317 Tw T* (\027\031\033 \f\021\030\026\021\036\020\017\033 \035\036\004\036\027\017\ \016 \023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\b\030\024\027\017\004\036\f\022\017\n )Tj 0.237 Tw T* (\r\024\f\023\026\035\036\027\017\036\n \225\025\216 [3\2264]. \217\036\031\ \035\034\021\026\021\026\n\017 \n\036\021\026\026\027\026\035\017\026 )Tj 0.115 Tw T* [(L)35(o)-16(gana)15(t)-13(han A. \017)]TJ /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. [16] \007\024\022\026\026\027\024, \004\021\024 \023\036\ \030\r\017\004\027\024 )Tj 0.062 Tw T* (\031\001\017\021\t\036 \030\026\027\t \023\024\f\035\036 \017\f\f\036\004\ \036\027\017\016 \225\025\216 \026\032\017\r\026\033\021 \r)Tj /Span<>> BDC ( )Tj EMC (\021\036\004\036)Tj 0 Tw (-)Tj 0.032 Tw T* (\027\017\036 2 \027\036\007\036\035\034, \021\024\020\007\026 \022\026\022\ \030\026\027\t \023\031\021\036\n \r\021\024\030\017\004\027\024\020\024\ \027\026\021\016)Tj 0 Tw (-)Tj 0.023 Tw T* (\032\036\027\017\016 \023\024\035\027\024\f\021\034\033 \220\023\017\021\ \036\035\017\017\030\031\033\021\f\016 \024\022\024\035\024 2 \n\036\f\016\ \006\036\r. )Tj -0.053 Tw T* (\203\036\f\n\024\021\030\016 \027\026)Tj /Span<>> BDC ( )Tj EMC (\002\t\f\021\030\024\036 \026\032\017\r\035\036\027\017\036 \023\030\017\ )Tj /Span<>> BDC ( )Tj EMC (\031\001\017\r\026\027\017\017 \030\026\027\t )Tj 0.13 Tw T* [(\023\024\f\035\036 )0.5(\017\f\f\036\004\036\027\017\016 )0.6(\225\025\216, )0.5(\030\017\f\022 )0.6(\030\036\006\017\007\017\r\026 )0.5(\031\r\036\035\017\004\017\r\026\036\021\f\016 )]TJ 0.05 Tw T* (\007\024)Tj /Span<>> BDC ( )Tj EMC (58% \023\024)Tj /Span<>> BDC ( )Tj EMC [(\f\030\026\r\027\036\027\017\033 )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC (\024\021\022\030\t\021\t\n \f\023\024\f\024\002\024\n \r\036\007\036\027\ \017\016 )Tj 0.003 Tw T* (\030\026\027\t \007\024)Tj /Span<>> BDC ( )Tj EMC (\023\024\035\027\024\020\024 \026\032\017\r\035\036\027\017\016 \023\031\ \021\036\n \r\021\024\030\017\004\027\024\020\024 \027\026\021\016)Tj 0 Tw (-)Tj T* (\032\036\027\017\016 [17\22618].)Tj -0.034 Tw T* [(\204\036\f\021\027\024\036 \023\030\017\n\036\027\036\027\017\036 )0.5(\026\031\021\024\023\035\026\n\t, \024\002\024\020\026\013\036\027\027\024\ \005 )0.5(\021\030\024\n)]TJ 0 Tw (-)Tj 0.285 Tw T* (\002\024\006\017\021\026\n\017, \016\r\035\016\036\021\f\016 \024\007\027\ \017\n \017)Tj /Span<>> BDC ( )Tj EMC (\007\024\f\021\031\023\027\t\b \f\023\024\f\024\002\024\r )Tj 0.124 Tw T* (\031\035\031\004\001\036\027\017\016 \022\026\004\036\f\021\r\026 \035\036\ \004\036\027\017\016 \027\036 \021\024\035\034\022\024 \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r )Tj 0.277 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC [(\024\f\021\030\t\n )0.5([9\22610] \017)]TJ /Span<>> BDC ( )Tj EMC [(\b\030\024\027\017\004\036\f\022\017\n \r\024\f\023\026\035\036\027\017\036\ \n )0.5(\225\025\216 )]TJ 0.122 Tw T* ([3\2266], \027\024 \017)Tj /Span<>> BDC ( )Tj EMC (\r \007\030\031\020\017\b \024\002\035\026\f\021\016\b \n\036\007\017\006\ \017\027\t, \021\026\022\017\b \022\026\022: )Tj 0.136 Tw T* (\024\002\013\026\016 \b\017\030\031\030\020\017\016, \f\021\024\n\026\021\ \024\035\024\020\017\016, \021\030\026\r\n\026\021\024\035\024\020\017\016\ \017)Tj /Span<>> BDC ( )Tj EMC (\024\030)Tj 0 Tw (-)Tj 0.09 Tw T* (\021\024\023\036\007\017\016, \f\023\024\030\021\017\r\027\026\016 \n\036\ \007\017\006\017\027\026, \022\024\f\n\036\021\024\035\024\020\017\016 \017\ )Tj /Span<>> BDC ( )Tj EMC (\007\036\030)Tj 0 Tw (-)Tj T* (\n\026\021\024\035\024\020\017\016, \022\024\n\002\031\f\021\017\024\035\ \024\020\017\016 [7].)Tj 0.186 Tw T* [(\230\030\024\n\002\024\006\017\021\t )0.5(\r\t\023\024\035\027\016\033\021 )0.6(\022\035\033\004\036\r\031\033 )0.6(\030\024\035\034 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 18.291 0 Td (\023\030\024\006\036\f\f\036 )Tj -0.019 Tw -18.291 -1.218 Td (\026\032\017\r\035\036\027\017\016 \023\024\r\030\036\032\007\036\027\027\ \t\b \021\022\026\027\036\005, \007\036\005\f\021\r\031\016 \022\026\022\ \023\030\024)Tj 0 Tw (-)Tj 0.057 Tw T* (\n\036\032\031\021\024\004\027\024\036 \r\036\027\024 \002\035\026\020\024\ \007\026\030\016 \f\r\024\036\005 \f\023\024\f\024\002\027\024\f\021\017\ \r\t)Tj 0 Tw (-)Tj 0.048 Tw T* (\007\036\035\016\021\034 \017)Tj /Span<>> BDC ( )Tj EMC (\274-\020\030\026\027\031\035 \f\035\036\007\031\033\013\017\036 \022\024\ \n\023\024\027\036\027\021\t: \021\030\024\n\002\024)Tj 0 Tw (-)Tj 0.142 Tw T* (\006\017\021\026\030\027\t\005 \235\026\022\021\024\030 \030\024\f\021\026\ \(PDGF\), \021\030\026\027\f\235\024\030\n\017\030\031\033\013\017\005 \ )Tj ET q 42.52 206.896 453.543 83.236 re W n q /GS0 gs 453.543294 0 0 83.2695888 42.5196838 206.8626439 cm /Im0 Do Q Q BT 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0 Tw 9 0 0 9 42.5197 196.0959 Tm (\022\t\217\210\b\002\220 12.)Tj 0 0 0 1 k /GS1 gs /T1_1 1 Tf [( \211\037\024\035\034\035\037 \033\037\031\036\022\035\022\030 \f\034\024\ \027\016\034\f\016\033\037\007\022\034\020\020\032\002 \034\024\027\034\201\ \020\016\020\022\004 \(\022\020)0.5(\017\022\007\022\033\034\036\037\020\022\016 \033\037\020\032\))]TJ 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0 -1.2 TD [(F)-16(igure 1)94.1(2)16(.)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf [( F)27(req)14(uency of)]TJ /Span<>> BDC ( )Tj EMC [(postoperativ)13.2(e com)16(plications \(w)12.1(ound infection\))]TJ ET q 42.52 100.97 453.543 73.822 re W n q /GS0 gs 453.543294 0 0 73.910759 42.5196838 100.8812179 cm /Im1 Do Q Q BT 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 9 0 0 9 42.5197 90.1701 Tm (\022\t\217\210\b\002\220 13.)Tj 0 0 0 1 k /GS1 gs /T1_1 1 Tf ( \t\033\034\b\034\027\201\022\035\016\027\003\020\034\024\035\003 \f\016\ \033\022\034\b\037 \020\016\035\033\023\b\034\024\f\034\024\034\025\020\034\ \024\035\022 \f\034\024\027\016 \036\032\f\034\027\020\016\020\022\030 \002\ \022\033\023\033\013\022\005\016\024\021\034\013\034 \036\006\016\001\037\ \035\016\027\003\024\035\036\037)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf T* [(F)-16(igure 1)93.1(3.)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf [( P)15(er)-37(iod of)]TJ /Span<>> BDC ( )Tj EMC [(retur)-13.8(n to)]TJ /Span<>> BDC ( )Tj EMC [(w)12(ork af)-45.9(ter surg)12.1(er)-43(y)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\007\003\032)50(\n\n\217\n)-21(\035\030\002)]TJ 53.418 0 Td [(MET)30(A)-41(-)-41.9(ANAL)30(Y)30(SIS)]TJ /T1_5 1 Tf 25 0 0 25 505.6396 56.0378 Tm (147)Tj ET endstream endobj 1431 0 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.ėAyeLPtDq1ڇ~gaxy%M% 4UJNʳ# N]/#K91ZI"!f13ӇH-YD/6')=J"R[RJFeR}nsE*N 2:yHs[:(IhB(993 ='s|(*OJ%I)Datd!#Yd@.heA8rt#RpJe^.Mw pr&f؎v^,bTsgڒ, Y!/ ;>fztM/Q/"F37uL$PwB!BЪB<!B!@!B!B!@!B!B!@!B!B!@!B!B!@!B!B!@!B!B!@!B!B!@!B!B!@!B!B!@!B!B!@!B!!j] )$ Ű!B!@v3JS:j%;0B]E!tHKE!JJRTJR {aB!BfgaUDJQ QInjRRK{L[B* JZJI&rb@!B!B!@! endstream endobj 1460 0 obj <>stream endstream endobj 1459 0 obj <>stream endstream endobj 1425 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.261 Tw 10 0 0 10 70.8661 724.8299 Tm (\225\025\216 \f)Tj /Span<>> BDC ( )Tj EMC (\024\021\022\030\t\021\t\n \f\023\024\f\024\002\024\n \r\036\007\036\027\ \017\016 \030\026\027\t \023\024)Tj /Span<>> BDC ( )Tj EMC (\f\030\026\r)Tj 0 Tw (-)Tj 0.382 Tw 0 -1.218 TD (\027\036\027\017\033 \f)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\024\005 \017\024\035\017\030\024\r\026\027\027\024\ \020\024 \017\f\f\036\004\036\027\017\016 \225\025\216 )Tj 0.131 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\024\021\022\030\t\021\t\n \f\023\024\f\024\002\024\n \r\036\007\036\027\ \017\016 \030\026\027\t \(\030\026\027\017\006\026 \f\030\036\007)Tj 0 Tw (-)Tj -0.019 Tw T* (\027\017\b)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (5,73, 95% \212\236: 2,94\2268,53, )Tj /T1_1 1 Tf 0 Tw (p)Tj /T1_0 1 Tf -0.019 Tw /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (0,000001\). \215\030\017)Tj /Span<>> BDC ( )Tj EMC (\026\027\026)Tj 0 Tw (-)Tj 0.162 Tw T* (\035\017\036 \r\t\016\r\035\036\027 \r\t\f\024\022\017\005 \031\030\024\ \r\036\027\034 \020\036\021\036\030\024\020\036\027\027\024\f\021\017, \020\ \007\036 )Tj 0 Tw T* (I)Tj 5.83 0 0 5.83 74.6061 667.2699 Tm (2)Tj /Span<>> BDC 10 0 0 10 77.5211 663.9399 Tm ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (83% \(\217\017\f.)Tj /Span<>> BDC ( )Tj EMC (8\).)Tj 0.02 Tc 0.022 Tw -0.665 -1.218 Td [(\215\024 )0.5(\f\030\026\r\027\017\r\026\036\n\024\n\031 )0.6(\023\024\022\026\026\021\036\035\033 )0.5(\024\002\255\036\n )0.6(\030\026\027\036\r\024\020\024 )0.5(\007\036)]TJ 0 Tc 0 Tw (-)Tj 0.02 Tc -0.06 Tw 0 -1.218 TD (\235\036\022\021\026 \(\f\n)Tj 0 Tc 0 Tw 5.83 0 0 5.83 112.549 642.9138 Tm (3)Tj 0.02 Tc -0.06 Tw 10 0 0 10 115.5806 639.5838 Tm (\) \027\026)Tj /Span<>> BDC ( )Tj EMC (20 \007\036\027\034 \023\024\f\035\036 \r\t\023\024\035\027\036\027\017\016\ \024\023\036\030\026\021\017\r)Tj 0 Tc 0 Tw (-)Tj 0.02 Tc 0.053 Tw -4.471 -1.218 Td [(\027\024\020\024 )0.5(\r\n\036\001\026\021\036\035\034\f\021\r\026 )0.5(\021\026\022\032\036 )0.5(\024\022\026\026\035\f\016 )0.5(\027\026\004\017\n\024 )0.5(\027\017\032\036)20( )]TJ 0.255 Tw 0 -1.218 TD (\r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \n\036\f\021\027\024\020\024 \023\030\017\n\036\ \027\036\027\017\016 PRP \r)Tj /Span<>> BDC ( )Tj EMC [(\f\024\004\036\021\026\027\017\017)20( )]TJ 0.203 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\017\f\f\036\004\036\027\017\036\n \225\025\216 \f)Tj /Span<>> BDC ( )Tj EMC [(\024\021\022\030\t\021\t\n \f\023\024\f\024\002\024\n \r\036\007\036\027\ \017\016)20( )]TJ 0.079 Tw T* (\030\026\027\t \(\030\026\027\017\006\026 \f\030\036\007\027\017\b)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC [(6,62, 95% \212\236: 6,14\2267,10,)20( )]TJ /T1_1 1 Tf 0 Tc 0 Tw T* (p)Tj /T1_0 1 Tf 0.02 Tc /Span<>> BDC 0.498 0 Td ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (0,00001\) \(\217\017\f.)Tj /Span<>> BDC ( )Tj EMC (9\).)Tj 0.686 Tw -0.498 -1.218 Td (\215\030\024\007\024\035\032\017\021\036\035\034\027\024\f\021\034 \026\ \032\017\r\035\036\027\017\016 \023\024\f\035\036\024\023\036\030\026\006\ \017)Tj 0 Tc 0 Tw (-)Tj 0.02 Tc 0.346 Tw T* [(\024\027\027\024\005 \030\026\027\t \(\007\027\017\) \f\021\026\021\017\f\ \021\017\004\036\f\022\017 \027\026\004\017\n\024 \027\017\032\036)20( )]TJ 0.255 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \n\036\f\021\027\024\020\024 \023\030\017\n\036\ \027\036\027\017\016 PRP \r)Tj /Span<>> BDC ( )Tj EMC [(\f\024\004\036\021\026\027\017\017)20( )]TJ 0.203 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\017\f\f\036\004\036\027\017\036\n \225\025\216 \f)Tj /Span<>> BDC ( )Tj EMC [(\024\021\022\030\t\021\t\n \f\023\024\f\024\002\024\n \r\036\007\036\027\ \017\016)20( )]TJ 0.11 Tw T* (\030\026\027\t \023\024)Tj /Span<>> BDC ( )Tj EMC (\f\030\026\r\027\036\027\017\033 \f)Tj /Span<>> BDC ( )Tj EMC [(\017\024\035\017\030\024\r\026\027\027\t\n \017\f\f\036\004\036\027\017\ \036\n)19.9( )]TJ 0.108 Tw T* (\225\025\216 \f)Tj /Span<>> BDC ( )Tj EMC [(\024\021\022\030\t\021\t\n \f\023\024\f\024\002\024\n \r\036\007\036\027\ \017\016 \030\026\027\t \(\030\026\027\017\006\026)20( )]TJ -0.027 Tw T* (\f\030\036\007\027\017\b)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (19,01, 95% \212\236: 6,40\22631,63, )Tj /T1_1 1 Tf 0 Tc 0 Tw (p)Tj /T1_0 1 Tf 0.02 Tc -0.027 Tw /Span<>> BDC 16.607 0 Td ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC [(0,000001\).)20( )]TJ 0.073 Tw 6.637 23.138 Td (\215\030\017)Tj /Span<>> BDC ( )Tj EMC 2.006 0 Td [(\026\027\026\035\017\036 )0.5(\r\t\016\r\035\036\027 )0.5(\r\t\f\024\022\017\005 )0.5(\031\030\024\r\036\027\034 )0.5(\020\036\021\036\030\024\020\036\027)]TJ 0 Tc 0 Tw (-)Tj 0.02 Tc -2.006 -1.218 Td (\027\024\f\021\017, \020\007\036 I)Tj 0 Tc 5.83 0 0 5.83 352.7362 715.9819 Tm (2)Tj 0.02 Tc /Span<>> BDC 10 0 0 10 355.7678 712.6519 Tm ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (98% \(\217\017\f.)Tj /Span<>> BDC ( )Tj EMC (10\).)Tj 0.04 Tc 0.493 Tw -5.246 -1.218 Td [(\215\030\024\007\024\035\032\017\021\036\035\034\027\024\f\021\034 \002\024\ \035\036\r\024\020\024 \f\017\027\007\030\024\n\026 \(\007\027\017\))40( )]TJ 0.19 Tw T* (\024\022\026\026\035\026\f\034 \027\026\004\017\n\024 \r\t\001\036 \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \017\024\035\017\030\024\r\026\027)Tj 0 Tc 0 Tw (-)Tj 0.04 Tc 0.279 Tw T* (\027\024\020\024 \017\f\f\036\004\036\027\017\016 \225\025\216 \f)Tj /Span<>> BDC ( )Tj EMC (\024\021\022\030\t\021\t\n \f\023\024\f\024\002\024\n \r\036)Tj 0 Tc 0 Tw (-)Tj 0.04 Tc 0.132 Tw T* (\007\036\027\017\016 \030\026\027\t \(\030\026\027\017\006\026 \f\030\036\ \007\027\017\b)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC [(10,46, 95% \212\236:)40( )]TJ -0.04 Tw T* (2,20\22618,72, )Tj /T1_1 1 Tf 0 Tc 0 Tw 5.504 0 Td (p)Tj /T1_0 1 Tf 0.04 Tc 0.18 Tw /Span<>> BDC 0.518 0 Td ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (0,00001\). \215\030\017)Tj /Span<>> BDC ( )Tj EMC [(\026\027\026\035\017\036 \r\t\016\r\035\036\027)40( )]TJ 0.221 Tw -6.022 -1.218 Td (\r\t\f\024\022\017\005 \031\030\024\r\036\027\034 \020\036\021\036\030\024\ \020\036\027\027\024\f\021\017, \020\007\036 I)Tj 0 Tc 0 Tw 5.83 0 0 5.83 487.596 642.9138 Tm (2)Tj 0.04 Tc 0.221 Tw /Span<>> BDC 10 0 0 10 490.7442 639.5838 Tm ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC [(99%)40( )]TJ 0 Tw -18.744 -1.218 Td (\(\217\017\f.)Tj /Span<>> BDC ( )Tj EMC (11\).)Tj 0.01 Tc 0.203 Tw T* [(\224\021\026\021\017\f\021\017\004\036\f\022\017 \027\026\004\017\n\024\ \005 \030\026\027\017\006\t \n\036\032\007\031 \020\030\031\023\023\026\ \n\017)10( )]TJ 0.274 Tw T* (\f\030\026\r\027\036\027\017\016 \r)Tj /Span<>> BDC ( )Tj EMC (\024\021\027\024\001\036\027\017\017 \004\026\f\021\024\021\t \030\026\r\ \017\021\017\016 \023\024\f\035\036)Tj 0 Tc 0 Tw (-)Tj 0.01 Tc 0.113 Tw T* [(\024\023\036\030\026\006\017\024\027\027\t\b \024\f\035\024\032\027\036\027\ \017\005 \(\017\027\235\017\006\017\030\024\r\026\027\017\036 \030\026\027\ \t\))10( )]TJ 0.018 Tw T* (\007\024\f\021\017\020\027\031\021\024 \027\036 \002\t\035\024 \(\210\221\ )Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (3,92, 95% \212\236:)Tj /Span<>> BDC ( )Tj EMC [(1,01\22615,22,)10( )]TJ /T1_1 1 Tf 0 Tc 0 Tw T* (p)Tj /T1_0 1 Tf 0.01 Tc /Span<>> BDC 0.488 0 Td ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,05\) \(\217\017\f.)Tj /Span<>> BDC ( )Tj EMC (12\).)Tj 0.361 Tw -0.488 -1.218 Td (\215\030\024\007\024\035\032\017\021\036\035\034\027\024\f\021\034 \023\036\ \030\017\024\007\026 \r\030\036\n\036\027\027\024\005 \027\036\021\030\031\ \007\024)Tj 0 Tc 0 Tw (-)Tj 0.01 Tc 0.309 Tw T* (\f\023\024\f\024\002\027\024\f\021\017 \(\007\027\017\) \023\024\f\035\036\ \r\t\023\024\035\027\036\027\017\016 \b\017\030\031\030\020\017\004\036\ )Tj 0 Tc 0 Tw (-)Tj 0.01 Tc 0.401 Tw T* [(\f\022\024\020\024 \r\n\036\001\026\021\036\035\034\f\021\r\026 \024\022\ \026\026\035\026\f\034 \027\026\004\017\n\024 \n\036\027\034\001\036)10( )]TJ 0.327 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \n\036\f\021\027\024\020\024 \023\030\017\n\036\ \027\036\027\017\016 PRP \r)Tj /Span<>> BDC ( )Tj EMC [(\f\024\004\036\021\026\027\017\017)10( )]TJ 0.275 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\017\f\f\036\004\036\027\017\036\n \225\025\216 \f)Tj /Span<>> BDC ( )Tj EMC [(\024\021\022\030\t\021\t\n \f\023\024\f\024\002\024\n \r\036\007\036\027\ \017\016)10( )]TJ 0.001 Tw T* [(\030\026\027\t )0.5(\(\030\026\027\017\006\026 )0.5(\f\030\036\007\027\017\b)]TJ /Span<>> BDC ( )Tj EMC 10.148 0 Td (=)Tj /Span<>> BDC ( )Tj EMC 0.753 0 Td [(12,80, )0.5(95% )0.5(\212\236: )0.5(3,62\22621,98,)10( )]TJ ET q 70.866 405.646 453.543 68.102 re W n q /GS0 gs 453.543294 0 0 68.1514791 70.8661346 405.5969035 cm /Im0 Do Q Q BT 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0 Tc 0 Tw 9 0 0 9 70.8661 394.8459 Tm (\022\t\217\210\b\002\220 8.)Tj 0 0 0 1 k /GS1 gs /T1_1 1 Tf ( \240\025\206\016\006 \033\037\020\016\036\034\013\034 \b\016\017\016\021\ \035\037 \020\037)Tj /Span<>> BDC ( )Tj EMC [(15 \b\016\020\003 \f\034\024\027\016 \036\032\f\034\027\020\016\020\022\030\ \034\f)0.5(\016\033\037\035\022\036\020\034\013\034 \036\006\016\001\037\035\016\027\ \003\024\035\036\037)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0 -1.2 TD [(F)-16(igure 8.)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf [( W)29(ound v)13(olume at d)26.1(ay 15 af)-45.9(ter surg)12.1(er)-43(y)]TJ ET q 70.866 305.439 453.543 68.103 re W n q /GS0 gs 453.543294 0 0 68.1514791 70.8661194 305.3905741 cm /Im1 Do Q Q BT 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 9 0 0 9 70.8661 294.6396 Tm (\022\t\217\210\b\002\220 9.)Tj 0 0 0 1 k /GS1 gs /T1_1 1 Tf ( \240\025\206\016\006 \033\037\020\016\036\034\013\034 \b\016\017\016\021\ \035\037 \020\037)Tj /Span<>> BDC ( )Tj EMC [(20 \b\016\020\003 \f\034\024\027\016 \036\032\f\034\027\020\016\020\022\030\ \034\f)0.5(\016\033\037\035\022\036\020\034\013\034 \036\006\016\001\037\035\016\027\ \003\024\035\036\037)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf T* [(F)-16(igure 9)32.1(.)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf [( W)29(ound v)13(olume at d)26.1(ay 20 af)-45.9(ter surg)12.1(er)-43(y)]TJ ET q 70.866 199.514 453.543 73.822 re W n q /GS0 gs 453.543294 0 0 73.910759 70.8661194 199.4249343 cm /Im2 Do Q Q BT 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 9 0 0 9 70.8661 188.7138 Tm (\022\t\217\210\b\002\220 10.)Tj 0 0 0 1 k /GS1 gs /T1_1 1 Tf ( \207\033\034\021 \031\037\201\022\036\027\016\020\022\030 \f\034\024\027\ \016\034\f\016\033\037\007\022\034\020\020\034\004 \033\037\020\032)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf T* [(F)-16(igure 1)70.1(0.)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf [( W)29(ound healing time)]TJ ET q 70.866 100.97 453.543 66.44 re W n q /GS0 gs 453.543294 0 0 66.4716921 70.8661194 100.9381285 cm /Im3 Do Q Q BT 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 9 0 0 9 70.8661 90.1701 Tm (\022\t\217\210\b\002\220 11.)Tj 0 0 0 1 k /GS1 gs /T1_1 1 Tf ( \t\033\034\b\034\027\201\022\035\016\027\003\020\034\024\035\003 \025\034\ \027\016\036\034\013\034 \024\022\020\b\033\034\006\037)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf T* [(F)-16(igure 1)158.1(1)47(.)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf ( The)Tj /Span<>> BDC ( )Tj EMC (duration of)Tj /Span<>> BDC ( )Tj EMC (pain)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\007\003\032)50(\n\n\217\n)-21(\035\030\002)]TJ 53.418 0 Td [(MET)30(A)-41(-)-41.9(ANAL)30(Y)30(SIS)]TJ -53.418 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 2)69(4, \023\0224, 202)23(5)]TJ 43.013 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 2)69(4, \023\0224, 202)23(5)]TJ /T1_4 1 Tf 25 0 0 25 20.8652 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j35n!@o-!kJI 88l5vٛd.1 vb]ÂAPrkeOM%aC)'iE|:'ZINHRĴknݞc0;cʥ B*ߔ\ٻfΉrl.JRIލ YbFqGO &ҫ,Wc&LRouFbRFʑ;d̶K>Z.ZS0#Äu ȵIޭ.X9zF'썕glQhUĴJ$rԡA@IB9GrydD@iR%)kTvX]闈p%\βM[?>rgHDԂ@S[s ةI\.bR׮ Ѐcb*ދ,RL@RF. !#{Y,ȵ.dRH[ γY%mE\J&6k(=1gxl+}f[ڭ2;"\;tkJǨO٦ ed[fD(2ҵkiC 52:rЕͶ%e MX^RӲm{HBx3o ųmӭjK"c@3Ly ަJME91Gd٬;hTaB!B B!B!B B!B!B B!B!B B!B!B B!B!B B!B!B B!B!B B!B!B B!B!B B!B!B B!E&!IR}rj% N2.x kx#߷r}J,RRŒL3`8׮)N6ʛ^(Jf*R Йe7y^6_mk]6X"8M%؆F$KE2.Q1*JNDy@/Irij1, ND LĻ#nv%:йjȖNT+J&3GB=g)VE`L*;x%N*",!>stream endstream endobj 1482 0 obj <>stream endstream endobj 1481 0 obj <>stream endstream endobj 1480 0 obj <>stream endstream endobj 1479 0 obj <>stream endstream endobj 1469 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.005 Tw 10 0 0 10 70.8661 724.8299 Tm (\030\026\027\t \017)Tj /Span<>> BDC ( )Tj EMC (157)Tj /Span<>> BDC ( )Tj EMC (\(52,5%\))Tj /Span<>> BDC ( )Tj EMC 8.244 0 Td [(\227 \n\036\f\021\027\024\036 \023\030\017\n\036\027\036\027\017\036 )0.5(PRP \r)]TJ /Span<>> BDC ( )Tj EMC (\f\024)Tj 0 Tw (-)Tj -0.047 Tw -8.244 -1.218 Td (\004\036\021\026\027\017\017 \f)Tj /Span<>> BDC ( )Tj EMC (\017\f\f\036\004\036\027\017\036\n \225\025\216 \f)Tj /Span<>> BDC ( )Tj EMC (\024\021\022\030\t\021\t\n \f\023\024\f\024\002\024\n \r\036\007\036)Tj 0 Tw (-)Tj -0.002 Tw 0 -1.218 TD (\027\017\016 \030\026\027\t \007\035\016 \035\036\004\036\027\017\016 \b\ \030\024\027\017\004\036\f\022\024\020\024 \r\024\f\023\026\035\036\027\017\ \016 \225\025\216. )Tj 0.186 Tw T* [(\224\021\030\031\022\021\031\030\026 \024\023\017\f\026\027\017\016 )0.5(\030\036\031\035\034\021\026\021\024\r \n\036\021\026\026\027\026\035\017\ \026 )0.5(\023\030\036\007)]TJ 0 Tw (-)Tj T* (\f\021\026\r\035\036\027\026 \027\026)Tj /Span<>> BDC ( )Tj EMC (\030\017\f\031\027\022\036 2.)Tj 0.019 Tw T* (\210\006\036\027\022\026 \022\026\004\036\f\021\r\026 \017\f\f\035\036\007\ \024\r\026\027\017\005 \002\t\035\026 \023\030\024\r\036\007\036\027\026\ \r)Tj /Span<>> BDC ( )Tj EMC (\f\024)Tj 0 Tw (-)Tj 0.247 Tw 0 -1.218 TD (\024\021\r\036\021\f\021\r\017\017 \f)Tj /Span<>> BDC ( )Tj EMC [(Co)-16(chr)-33(ane r)-37(isk of)]TJ /Span<>> BDC ( )Tj EMC [(bias check l)-31(ist [14]. )]TJ 0.097 Tw 0 -1.218 TD (\211\f\021\026\027\024\r\035\036\027\024, \004\021\024 \023\024)Tj /Span<>> BDC ( )Tj EMC (\n\036\021\024\007\031 \030\026\027\007\024\n\017\026\006\017\017, \024\ \f\035\036\023\035\036)Tj 0 Tw (-)Tj 0.15 Tw T* (\027\017\033 \017\f\023\024\035\027\017\021\036\035\036\005 \017)Tj /Span<>> BDC ( )Tj EMC (\027\036\023\024\035\027\024\020\024 \024\023\017\f\026\027\017\016 \030\ \036\031\035\034\021\026)Tj 0 Tw (-)Tj 0.142 Tw T* (\021\024\r \035\036\004\036\027\017\016 \024\023\030\036\007\036\035\016\ \035\f\016 \r\t\f\024\022\017\005 \030\017\f\022 \024\021\022\035\024\027\ \036\027\017\016 )Tj 0.013 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (100% \023\031\002\035\017\022\026\006\017\016\b [3\2266]. \217\017\f\022\ \f\n\036\013\036\027\017\016 \030\036\031\035\034\021\026)Tj 0 Tw (-)Tj 0.094 Tw T* (\021\024\r \023\024)Tj /Span<>> BDC ( )Tj EMC (\022\030\017\021\036\030\017\033 \030\026\f\023\030\036\007\036\035\036\027\ \017\016 \023\026\006\017\036\027\021\024\r \023\024)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023)Tj 0 Tw (-)Tj 0.213 Tw 0 -1.218 TD (\023\026\n \024\f\021\026\r\026\035\f\016 \027\036\016\f\027\t\n \r\r\017\ \007\031 \027\036\023\024\035\027\024\020\024 \024\023\017\f\026\027\017\ \016 )Tj -0.004 Tw 0 -1.218 TD (\030\036\031\035\034\021\026\021\024\r \r)Tj /Span<>> BDC ( )Tj EMC (100% \017\f\f\035\036\007\024\r\026\027\017\005 [3\2266]. \210\f\035\036\ \023\035\036\027\017\036 )Tj 0.185 Tw 0 -1.218 TD (\017\f\f\035\036\007\024\r\026\021\036\035\016 \022\026\022 \n\036\021\024\ \007 \f\027\017\032\036\027\017\016 \030\017\f\022\026 \023\030\036\007\r\ \016)Tj 0 Tw (-)Tj 0.17 Tw T* [(\021\024\f\021\017 )0.5(\002\t\035\024 )0.6(\r\t\023\024\035\027\036\027\024 )0.5(\035\017\001\034 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC [(1 )0.6(\017\f\f\035\036\007\024\r\026\027\017\017 )0.5([4]. )]TJ -0.011 Tw T* (\215\024\035\027\026\016 \024\021\004\036\021\027\024\f\021\034 \002\t\035\ \026 \023\030\024\r\036\007\036\027\026 \r)Tj /Span<>> BDC ( )Tj EMC (75% \017\f\f\035\036\007\024\r\026)Tj 0 Tw (-)Tj -0.049 Tw T* (\027\017\005 [3\2265], \021\024\020\007\026 \022\026\022 \r)Tj /Span<>> BDC ( )Tj EMC (\023\031\002\035\017\022\026\006\017\017 Boztug C.Y. \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. )Tj 0.055 Tw T* ([6] \004\026\f\021\024\021\026 \030\026\r\017\021\017\016 \017\027\235\017\ \006\017\030\024\r\026\027\017\016 \023\024\f\035\036\024\023\036\030\026\ \006\017)Tj 0 Tw (-)Tj 0.007 Tw T* (\024\027\027\024\005 \030\026\027\t \027\036 \023\030\024\f\035\036\032\017\ \r\026\035\026\f\034. \211\004\017\021\t\r\026\016 \007\026\027\027\t\036\ \024\002 )Tj 0.099 Tw T* (\024\006\036\027\022\036 \030\017\f\022\026 \f\n\036\013\036\027\017\016\ \030\036\031\035\034\021\026\021\024\r, \n\024\032\027\024 \f\007\036\035\ \026\021\034 )Tj -0.01 Tw T* (\r\t\r\024\007 \024)Tj /Span<>> BDC ( )Tj EMC (\f\024\n\027\017\021\036\035\034\027\024\n \022\026\004\036\f\021\r\036 \ \017\f\f\035\036\007\024\r\026\027\017\005, \r\022\035\033)Tj 0 Tw (-)Tj T* (\004\036\027\027\t\b \r)Tj /Span<>> BDC ( )Tj EMC (\n\036\021\026\026\027\026\035\017 \(\217\017\f.)Tj /Span<>> BDC ( )Tj EMC (3\).)Tj /T1_1 1 Tf 0 -2.436 TD (\200\006\002\r\006\220\004 \b\004)Tj /Span<>> BDC ( )Tj EMC (\002\240\b\002\006\002\240\b\002\217\003\001)Tj /T1_0 1 Tf 0.006 Tc 0.24 Tw 0 -1.218 TD (\224\021\026\021\017\f\021\017\004\036\f\022\017 \027\026\004\017\n\t\b\ \030\026\035\017\004\017\005 \023\024)Tj /Span<>> BDC ( )Tj EMC (\023\024\035\031 \017)Tj /Span<>> BDC ( )Tj EMC (\r\024)Tj 0 Tc 0 Tw (-)Tj 0.006 Tc 0.776 Tw T* [(\030\026\f\021\031 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 4.766 0 Td [(\f\030\026\r\027\017\r\026\036\n\t\b )0.5(\020\030\031\023\023\026\b )0.5(\r\t\016\r\035\036\027\024 )0.5(\027\036)6( )]TJ 0.353 Tw -4.766 -1.218 Td (\002\t\035\024 \(\210\221)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (1,13, 95% \212\236: 0,50\2262,52, )Tj /T1_2 1 Tf 0 Tc 0 Tw (\033)Tj /T1_0 1 Tf 0.006 Tc 0.353 Tw /Span<>> BDC 18.4 0 Td ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC [(0,77;)6( )]TJ -0.039 Tw 4.844 32.881 Td [(\030\026\027\017\006\026 )0.5(\f\030\036\007\027\017\b)]TJ /Span<>> BDC ( )Tj EMC 7.249 0 Td (=)Tj /Span<>> BDC ( )Tj EMC 0.705 0 Td [(0,18, )0.5(95% )0.5(\212\236: )0.5(\2312,43\2262,78, )]TJ /T1_2 1 Tf 0 Tc 0 Tw 10.688 0 Td (\033)Tj /T1_0 1 Tf 0.006 Tc -0.039 Tw /Span<>> BDC 0.484 0 Td ( )Tj EMC 0.199 0 Td (=)Tj /Span<>> BDC ( )Tj EMC 0.705 0 Td [(0,89\))6( )]TJ 0 Tw -20.031 -1.218 Td (\(\217\017\f.)Tj /Span<>> BDC ( )Tj EMC (4\202-\207\).)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0.01 Tc 0.018 Tw 14 0 0 14 303.3769 676.1179 Tm [(\033\034\020)21(\223)50(\r\237)46(\024)52(\026)45(\024\232)5( \r\034\224\034\022\031\025)]TJ 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0 Tc 0.296 Tw 10 0 0 10 303.3071 651.7618 Tm (\217\026\027\017\006\t \n\036\032\007\031 \020\030\031\023\023\026\n\017\ \f\030\026\r\027\036\027\017\016 \r)Tj /Span<>> BDC ( )Tj EMC (\024\021\027\024\001\036\027\017\017 )Tj 0.091 Tw T* (\024\002\255\036\n\026 \030\026\027\036\r\024\020\024 \007\036\235\036\022\ \021\026 \027\026)Tj /Span<>> BDC ( )Tj EMC (0 \007\036\027\034 \023\024\f\035\036 \r\t\023\024\035\027\036)Tj 0 Tw (-)Tj 0.204 Tw T* [(\027\017\016 \024\023\036\030\026\021\017\r\027\024\020\024 )0.5(\r\n\036\001\026\021\036\035\034\f\021\r\026 )0.5(\(\f\n)]TJ 0 Tw 5.83 0 0 5.83 463.6632 630.7358 Tm (3)Tj 0.204 Tw 10 0 0 10 466.5782 627.4058 Tm (\) \027\036 \031\f\021\026\027\024\r)Tj 0 Tw (-)Tj 0.09 Tw -16.327 -1.218 Td (\035\036\027\024 \(\030\026\027\017\006\026 \f\030\036\007\027\017\b)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (\2310,74, 95% \212\236: \2312,64\2261,15, )Tj /T1_2 1 Tf 0 Tw T* (p)Tj /T1_0 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,44\) \(\217\017\f. 5\).)Tj ET q 70.866 122.57 221.102 257.695 re W n q /GS0 gs 221.1023475 0 0 257.8327266 70.8661504 122.4324111 cm /Im0 Do Q Q BT 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 9 0 0 9 70.8661 111.7701 Tm (\022\t\217\210\b\002\220 2.)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf ( \207\035\033\023\021\035\023\033\037 \034\f\022\024\037\020\022\030 \033\ \016\031\023\027\003\035\037\035\034\036 \006\016\035\037\037\020\037\027\ \022)Tj (-)Tj 0 -1.2 TD (\031\037)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0.019 Tw T* [(F)-16(igure 2)16(.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf ( The)Tj /Span<>> BDC ( )Tj EMC (structure of)Tj /Span<>> BDC ( )Tj EMC [(the descr)-37(ip)13(tion of)]TJ /Span<>> BDC ( )Tj EMC (the meta-analysis )Tj 0 Tw T* (results)Tj ET q 303.307 495.509 221.102 88.299 re W n q /GS0 gs 221.1023475 0 0 88.3449144 303.3070555 495.4631317 cm /Im1 Do Q Q q 303.307 198.17 221.102 286.835 re W n q /GS0 gs 221.1023475 0 0 286.8808956 303.3070555 198.1246767 cm /Im2 Do Q Q BT 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0.057 Tw 9 0 0 9 303.3071 187.3701 Tm (\022\t\217\210\b\002\220 3.)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf [( \240\007\016\020\021\037 )0.5(\033\022\024\021\037 \024\006\016\235\016\020\022\030 )0.5(\036)]TJ /Span<>> BDC ( )Tj EMC [(\022\024\024\027\016\b\034\036\037\020\022\030\002, )0.6(\024\033\037\036)]TJ 0 Tw (-)Tj 0.063 Tw T* (\020\022\036\037\026\235\022\002 \006\016\024\035\020\034\016 \f\033\022\ \006\016\020\016\020\022\016 PRP \036)Tj /Span<>> BDC ( )Tj EMC (\024\034\005\016\035\037\020\022\022 \024)Tj /Span<>> BDC ( )Tj EMC (\022\024\024\016\005\016)Tj 0 Tw (-)Tj 0.097 Tw T* (\020\022\016\006 \203\r\212 \024)Tj /Span<>> BDC ( )Tj EMC (\034\035\021\033\032\035\032\006 \024\f\034\024\034\025\034\006 \036\016\ \b\016\020\022\030 \033\037\020\032 \022)Tj /Span<>> BDC ( )Tj EMC (\022\031\034\027\022\033\034)Tj 0 Tw (-)Tj -0.039 Tw T* (\036\037\020\020\034\013\034 \022\024\024\016\005\016\020\022\030 \203\r\ \212 \024)Tj /Span<>> BDC ( )Tj EMC (\034\035\021\033\032\035\032\006 \024\f\034\024\034\025\034\006 \036\016\ \b\016\020\022\030 \033\037\020\032 )Tj -0.003 Tw T* [(\b\027\030 )0.5(\027\016\005\016\020\022\030 )0.5(\002\033\034\020\022\005\016\024\021\034\013\034 )0.5(\036\034\024\f\037\027\016\020\022\030 )0.5(\203\r\212 )0.5(\036)]TJ /Span<>> BDC ( )Tj EMC (\024\034\034\035\036\016\035\024\035\036\022\022 )Tj 0 Tw T* (\024)Tj /Span<>> BDC ( )Tj EMC (Cochrane risk of)Tj /Span<>> BDC ( )Tj EMC (bias checklist)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0.409 Tw T* [(F)-16(igure 3.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf [( Assess)33(ment of)]TJ /Span<>> BDC ( )Tj EMC [(bias r)-37(isk in studies com)16(par)-37(ing )]TJ 0.063 Tw T* (the)Tj /Span<>> BDC ( )Tj EMC (lay)Tj /Span<>> BDC ( )Tj EMC (\227 open method with the)Tj /Span<>> BDC ( )Tj EMC (use of)Tj /Span<>> BDC ( )Tj EMC (platelet)Tj /Span<>> BDC ( )Tj EMC [(\227 r)-37(ich auto)]TJ 0 Tw (-)Tj 0.121 Tw T* [(plas)33(ma to)]TJ /Span<>> BDC ( )Tj EMC (the lay)Tj /Span<>> BDC ( )Tj EMC (\227 open method without using platelet)Tj /Span<>> BDC ( )Tj EMC (\227 )Tj 0.138 Tw T* [(r)-37(ich plas)33.1(ma for the)]TJ /Span<>> BDC ( )Tj EMC (treatment of)Tj /Span<>> BDC ( )Tj EMC [(pilonid)26.1(al disease, according )]TJ 0 Tw T* (to)Tj /Span<>> BDC ( )Tj EMC [(the Cochrane r)-36.8(isk of)]TJ /Span<>> BDC ( )Tj EMC (bias check list)Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\007\003\032)50(\n\n\217\n)-21(\035\030\002)]TJ 53.418 0 Td [(MET)30(A)-41(-)-41.9(ANAL)30(Y)30(SIS)]TJ -53.418 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 2)69(4, \023\0224, 202)23(5)]TJ 43.013 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 2)69(4, \023\0224, 202)23(5)]TJ /T1_5 1 Tf 25 0 0 25 20.9403 56.0378 Tm (144)Tj ET endstream endobj 1470 0 obj <>stream AdobedC     '$''''$25552;;;;;;;;;;:   w!5t"1#3AQar2RU$BST %&'()*46789:CDEFGHIJVWXYZbcdefghijqsuvwxyz?@CNҜ#S-My$j3INKfGC˯e?jpeh:Sw_e?jpeh:Sw_e?jpeh:Sw_e?jpeh:Sw_e?jpeh:Sw_e?jpeh:Sw_e?jpeh} a/m܆C<\b!7+ 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at)Ym'f\V蒬’ڶk߱TV'>lU]غ ^[k(ѨuP]15+ӴFg5$cXg˪*ЧV9|a,2f,#N(Y,ЛN>'b*]J52)^nVb6JQΜfի_WĠ=8SԵuW߹waҘ6*.xUh[-\X],edۉ r}n7 }n/:u'UҘ6*.]t3N-ʍE}Z[ n6Ւc ֡R91h pF9b9%alxfƎr9p'ZNJr9I%o*ܮeGt'͊˻)brƠ-k[Ƶ}@/4So A$sCԪ0axU[ Vtj4Sz=UZ;<_pe~vxZ;<_pe~vxZ;<_pe~vxZ;<_pe~vxZ;<_pe~vxZ;<_pe~vxZ;<_pe~vxZ;<_pe~vxZ;<_pe~vxZ;<_pe~vxZ;<_pe~vxZ;<_pe~vxZ;<_pe~vxZ;<_pe~vxZ;<_pe~vxZ;<_pe~vxKmLvQXUlBۊRSIݮD endstream endobj 1486 0 obj <>stream endstream endobj 1485 0 obj <>stream endstream endobj 1484 0 obj <>stream endstream endobj 1468 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\007\016\b)-10(\026\215\025\016 \222\201\021\024\016\215\016\215\021\016 \001\200)-20(\026)11(\025\222\t\001\213\024\220, \025\235\025\202)10(\001\232\016\215\215\025\207 \026\201\025\024\235\025\212\021\026)11(\001\024\021, )]TJ 0 -1 TD [(\017\001\017 \b\222\025\b\025\235 \200\t\200\f\020\016\215\021\004 \201\016\ \213)21.1(\200\t\214)21(\026)11(\001\026)11(\025\r \025\222\016\201\001\026\021\r\215\025\202)10(\025 \t\016\f\016\215\021\004 )]TJ T* [(\201\025\215\021\f\016\b\017)10.1(\025\202)10(\025 \r\025\b\222\001\t\016\215\021\004 \242\222\021\026)11(\016\t\021\001\t\214\215\025\202)10.1(\025 \017)10(\025\222\f\021\017)10(\025\r\025\202)10(\025 \025\211\001 )]TJ T* [(\(\b\021\b)-10(\026)11(\016\024\001\026\021\f\016\b\017\021\207 \025\235\213\025\201 \t\021\026\ )11(\016\201\001\026)-20(\200\201\220 \021\022\024\016\026)11(\001\001\215\001\t\021\213\))]TJ 41.398 3 Td (A platelet rich plasma for pilonidal sinus disease )Tj 4.085 -1 Td [(\(s)10(y)10(stematic r)31(e)11(vie)11(w and meta-analy)10(sis\))]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0.119 Tw 10 0 0 10 42.5197 724.8299 Tm [(\007\r\024\005\027\024\020\024 )0.5(\001\023\030\017\006\026. )0.6(\215\030\017)]TJ /Span<>> BDC ( )Tj EMC 10.001 0 Td [(\027\026\002\024\030\036 )0.5(\022\024\027\006\036\027\021\030\026\021\026 )0.6(\021\030\024\n\002\024)]TJ 0 Tw (-)Tj 0.052 Tw -10.001 -1.218 Td (\006\017\021\024\r \r)Tj /Span<>> BDC ( )Tj EMC (\001\023\030\017\006 \024\002\255\036\n\024\n 10)Tj /Span<>> BDC ( )Tj EMC (\n\035 \017)Tj /Span<>> BDC ( )Tj EMC (\030\026\f\021\r\024\030\026 \021\030\024\n\002\017\027\026/)Tj 0.053 Tw 0 -1.218 TD (\020\035\033\022\024\027\026\021\026 \022\026\035\034\006\017\016 \r)Tj /Span<>> BDC ( )Tj EMC (\001\023\030\017\006 \024\002\255\036\n\024\n 1)Tj /Span<>> BDC ( )Tj EMC (\n\035 \002\t\035 \023\024\035\031)Tj 0 Tw (-)Tj 0.038 Tw T* [(\004\036\027 )0.5(\021\030\024\n\002\024\006\017\021\026\030\027\t\005 )0.5(\020\036\035\034. )0.5(\203\026)]TJ /Span<>> BDC ( )Tj EMC 12.627 0 Td [(4 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 1.559 0 Td [(12 )0.5(\007\036\027\034 )0.5(\023\024\f\035\036 )0.6(\024\023\036)]TJ 0 Tw (-)Tj -0.05 Tw -14.186 -1.218 Td (\030\026\021\017\r\027\024\020\024 \r\n\036\001\026\021\036\035\034\f\021\ \r\026 \220\021\031 \f\n\036\f\034 \027\026\027\024\f\017\035\017 \027\026\ )Tj /Span<>> BDC ( )Tj EMC (\030\026\027\031, )Tj 0 Tw T* (\023\024\f\035\036 \004\036\020\024 \036\036 \026\022\030\t\r\026\035\017\ \023\024\r\016\022\024\005 \027\026)Tj /Span<>> BDC ( )Tj EMC (2 \007\027\016.)Tj 0.033 Tw 0 -1.218 TD (\215\030\017\020\024\021\024\r\035\036\027\017\036 \020\036\035\016 PRP \ \031)Tj /Span<>> BDC ( )Tj EMC [(M)-24(ohammadi S. \017)]TJ /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. [3] )Tj 0.433 Tw 0 -1.218 TD (\023\030\024\r\024\007\017\035\024\f\034 \f)Tj /Span<>> BDC ( )Tj EMC [(\017\f\023\024\035\034\024\r\026\027\017\036\n \027\026\002\024\030\026\ R)11(o)-16(oy)22(a)-17(gen )]TJ 0.068 Tw T* [(PRP-Gel \(Ar)-24(y)22(a Mabna T)40(ashkhis Co, \236\030\026\027\). \215\031\021\036\n \023\031\027\022)]TJ 0 Tw (-)Tj 0.039 Tw T* (\006\017\017 \023\036\030\017\235\036\030\017\004\036\f\022\024\005 \r\036\ \027\t \023\030\024\017\r\024\007\017\035\017 \026\002\024\030 27)Tj /Span<>> BDC ( )Tj EMC (\n\035 )Tj 0.082 Tw T* (\022\030\024\r\017 \f)Tj /Span<>> BDC ( )Tj EMC [(\023\024\n\024\013\034\033 )0.5(\001\023\030\017\006\026, \f\024\007\036\030\032\026\013\036\020\024 3 \n\ \035 \006\017\021\030\026)]TJ 0 Tw (-)Tj 0.166 Tw T* (\021\026 \027\026\021\030\017\016 \r)Tj /Span<>> BDC ( )Tj EMC (\022\026\004\036\f\021\r\036 \026\027\021\017\022\024\026\020\031\035\016\ \027\021\026. \025\030\024\r\034 4 \030\026\026 )Tj 0.068 Tw 0 -1.218 TD [(\024\f\021\024\030\024\032\027\024 )0.5(\023\036\030\036\n\036\001\017\r\026\035\017, )0.6(\023\036\030\036\035\017\r\026\035\017 )0.6(\r)]TJ /Span<>> BDC ( )Tj EMC 17.302 0 Td [(3 )0.5(\023\030\024\002\017\030\022\017 )]TJ 0.069 Tw -17.302 -1.218 Td [(\024\002\255\036\n\024\n 10 )0.5(\n\035 \f)]TJ /Span<>> BDC ( )Tj EMC [(\023\024\n\024\013\034\033 )0.5(\026\007\026\023\021\036\030\026, )0.5(\023\024\007\022\035\033\004\036\027\027\024\020\024 )]TJ 0.08 Tw 0 -1.218 TD (\022)Tj /Span<>> BDC ( )Tj EMC (\001\023\030\017\006\031. \215\030\024\002\017\030\022\017 \006\036\027\021\ \030\017\235\031\020\017\030\024\r\026\035\017 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\024\021\027\024\f\017)Tj 0 Tw (-)Tj 0.025 Tw T* [(\021\036\035\034\027\024\005 )0.6(\006\036\027\021\030\024\002\036\032\027\024\005 )0.5(\f\017\035\036 )0.6(\030\026\r\027\024\005 )0.5(2000 )0.5(\020 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 18.83 0 Td (\021\036\004\036\027\017\036 )Tj 0.245 Tw -18.83 -1.218 Td (10 \n\017\027\031\021 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (24\263\224. \215\024\f\035\036 \023\036\030\r\024\020\024 \006\036\027\021\ \030\017\235\031\020\017\030\024)Tj 0 Tw (-)Tj 0.221 Tw T* [(\r\026\027\017\016 )0.5(\002\t\035\024 )0.5(\007\024\f\021\017\020\027\031\021\024 )0.6(2-\022\030\026\021\027\024\036 )0.5(\031\r\036\035\017\004\036\027\017\036 )0.6(\022\024\027)]TJ 0 Tw (-)Tj 0.29 Tw T* (\006\036\027\021\030\026\006\017\017 \021\030\024\n\002\024\006\017\021\024\ \r \r)Tj /Span<>> BDC ( )Tj EMC (\027\026\007\024\f\026\007\024\004\027\024\005 \032\017\007\022\024\f\021\ \017 )Tj 0.43 Tw T* (\023\035\026\n\t. \215\024\035\031\004\036\027\027\t\005 \021\030\024\n\ \002\024\006\017\021\026\030\027\t\005 \022\024\027\006\036\027\021\030\026\ \021 )Tj 0.326 Tw T* (\002\t\035 \023\036\030\036\027\036\f\036\027 \r\024 \r\021\024\030\031\033\ \023\030\024\002\017\030\022\031, \f\024\007\036\030\032\026\013\031\033\ )Tj 0.037 Tw T* (2)Tj /Span<>> BDC ( )Tj EMC (\n\035 25)Tj /Span<>> BDC ( )Tj EMC (m\204 \224\026\224l)Tj 0 Tw 5.83 0 0 5.83 109.2057 467.0918 Tm (2)Tj 0.037 Tw 10 0 0 10 112.1207 469.0918 Tm (, \004\021\024 \023\030\017\r\024\007\017\035\024 \022)Tj /Span<>> BDC ( )Tj EMC (\024\002\030\026\024\r\026\027\017\033 \020\036\035\016 )Tj 0.088 Tw -6.96 -1.218 Td (\004\036\030\036 20 \n\017\027\031\021. \200)Tj /Span<>> BDC ( )Tj EMC (\b\024\007\036 \220\021\024\005 \023\030\024\006\036\007\031\030\t \f\030\ \036\007\027\036\036 \022\024)Tj 0 Tw (-)Tj 0.114 Tw T* (\035\017\004\036\f\021\r\024 \021\030\024\n\002\024\006\017\021\024\r \r\ )Tj /Span<>> BDC ( )Tj EMC (\020\036\035\036 PRP \f\024\f\021\026\r\017\035\024 1)Tj /Span<>> BDC ( )Tj EMC (\327)Tj /Span<>> BDC ( )Tj EMC (10)Tj 0 Tw 5.83 0 0 5.83 260.7071 448.0658 Tm (7)Tj 10 0 0 10 263.6221 444.7358 Tm ( )Tj 0.001 Tw -22.11 -1.218 Td (\r)Tj /Span<>> BDC ( )Tj EMC (1 \n\035. \200)Tj /Span<>> BDC ( )Tj EMC (\220\022\f\023\036\030\017\n\036\027\021\026\035\034\027\024\005 \020\030\ \031\023\023\036 \023\026\006\017\036\027\021\026\n \f\030\026\031 )Tj -0.001 Tw T* (\023\024\f\035\036 \r\t\023\024\035\027\036\027\017\016 \017\f\f\036\004\ \036\027\017\016 \225\025\216 \023\030\024\017\r\024\007\017\035\017 \023\ \036\030\036)Tj 0 Tw (-)Tj 0.098 Tw T* (\r\016\022\031 \f)Tj /Span<>> BDC ( )Tj EMC (\017\f\023\024\035\034\024\r\026\027\017\036\n \020\036\035\016 PRP \017\ )Tj /Span<>> BDC ( )Tj EMC (\030\026\f\004\036\021\026 0,1 \f\n)Tj 0 Tw 5.83 0 0 5.83 260.7071 411.5318 Tm (3 )Tj 0.02 Tw 10 0 0 10 42.5197 396.0238 Tm (PRP/ 1)Tj /Span<>> BDC ( )Tj EMC (\f\n)Tj 0 Tw 5.83 0 0 5.83 82.5818 399.3538 Tm (2)Tj 0.02 Tw 10 0 0 10 85.4968 396.0238 Tm ( \030\026\027\t. \215\024\f\035\036 \n\036\f\021\027\024\020\024 \027\026\ \027\036\f\036\027\017\016 \020\036\035\016 PRP )Tj -0.01 Tw -4.298 -1.218 Td (\027\026)Tj /Span<>> BDC ( )Tj EMC (\030\026\027\031 \023\024\r\036\030\b\027\024\f\021\034 \002\t\035\026 \017\ \024\035\017\030\024\r\026\027\026 \024\021 \027\036\023\024\r\030\036\032\ )Tj 0 Tw (-)Tj 0.241 Tw T* [(\007\036\027\027\t\b )0.5(\021\022\026\027\036\005 )0.6(\f)]TJ /Span<>> BDC ( )Tj EMC 7.701 0 Td [(\006\036\035\034\033 )0.5(\023\030\036\007\024\021\r\030\026\013\036\027\017\016 )0.5(\n\017\020\030\026\006\017\017 )]TJ 0.117 Tw -7.701 -1.218 Td (\020\036\035\016 \f)Tj /Span<>> BDC ( )Tj EMC [(\017\f\023\024\035\034\024\r\026\027\017\036\n \f\021\036\030\017\035\034\ \027\024\020\024 )0.5(\027\036\026\035\035\036\030\020\036\027\027\024\020\024 )]TJ 0.092 Tw T* (\035\026\021\036\022\f\026. \232\036\030\036 24 \004\026\f\026 \035\026\ \021\036\022\f\027\024\036 \023\024\022\030\t\021\017\036 \031\007\026\035\ \016\035\017 )Tj 0.086 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\r\t\023\024\035\027\016\035\017 \023\036\030\036\r\016\022\031 \f)Tj /Span<>> BDC ( )Tj EMC (\026\002\f\024\030\002\017\030\031\033\013\036\005 \b\035\024\023\004\026\ \021\024)Tj 0 Tw (-)Tj 0.023 Tw T* (\002\031\n\026\032\027\024\005 \n\026\030\035\036\005. \200)Tj /Span<>> BDC ( )Tj EMC (\b\024\007\036 \f\035\036\007\031\033\013\017\b \023\036\030\036\r\016\024\ \022 \020\036\035\034 )Tj 0.059 Tw T* (PRP \020\024\021\024\r\017\035\017 \f)Tj /Span<>> BDC ( )Tj EMC (\017\f\023\024\035\034\024\r\026\027\017\036\n 0,9% \224\026\224l)Tj 0 Tw 5.83 0 0 5.83 218.3332 308.7778 Tm (2)Tj 0.059 Tw 10 0 0 10 221.2482 310.7778 Tm ( \r)Tj /Span<>> BDC ( )Tj EMC (\f\024\024\021\027\024)Tj 0 Tw (-)Tj 0.028 Tw -17.873 -1.218 Td (\001\036\027\017\017 4 \004\026\f\021\017 PRP \022)Tj /Span<>> BDC ( )Tj EMC (1 \004\026\f\021\017 0,9% \224\026\224l)Tj 0 Tw 5.83 0 0 5.83 201.6817 296.5998 Tm (2)Tj 0.028 Tw 10 0 0 10 204.5967 298.5998 Tm (. \225\021\024\021 \023\030\024\006\036\f\f )Tj 0.117 Tw -16.208 -1.218 Td (\023\024\r\021\024\030\016\035\017 \036\032\036\027\036\007\036\035\034\027\ \024 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\022\026\032\007\024\n \023\024\f\036\013\036\027\017\017 \023\026)Tj 0 Tw (-)Tj 0.207 Tw T* (\006\017\036\027\021\024\n \n\036\007\017\006\017\027\f\022\024\020\024 \ \031\004\030\036\032\007\036\027\017\016 \007\024)Tj /Span<>> BDC ( )Tj EMC (\023\024\035\027\024\020\024 \026)Tj 0 Tw (-)Tj T* (\032\017\r\035\036\027\017\016 \023\024\f\035\036\024\023\036\030\026\006\ \017\024\027\027\024\005 \030\026\027\t.)Tj -0.02 Tw T* (\236\027\255\036\022\006\017\024\027\027\026\016 \235\024\030\n\026 PRP \ \r)Tj /Span<>> BDC ( )Tj EMC (\017\f\f\035\036\007\024\r\026\027\017\017 Gohar)Tj /Span<>> BDC ( )Tj EMC (M.M. )Tj 0.014 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. [5] \020\024\021\024\r\017\035\026\f\034 \023\024)Tj /Span<>> BDC ( )Tj EMC (\007\r\024\005\027\024\005 \017\f\023\026\027\f\022\024\005 \021\036\b\027\ \024)Tj 0 Tw (-)Tj 0.235 Tw T* (\035\024\020\017\017. \200\027\026\004\026\035\036 \023\026\006\017\036\027\ \021\t \024\002\030\026\013\026\035\017\f\034 \r)Tj /Span<>> BDC ( )Tj EMC (\024\021\007\036\035\036\027\017\036 )Tj -0.007 Tw T* (\022\035\017\027\017\004\036\f\022\024\005 \023\026\021\024\035\024\020\017\ \017 \031\027\017\r\036\030\f\017\021\036\021\026, \020\007\036 \017)Tj /Span<>> BDC ( )Tj EMC (\f\030\036\007\027\036\005 )Tj 0.126 Tw T* (\035\024\022\021\036\r\024\005 \r\036\027\t \023\030\036\007\023\035\036\ \004\034\016 \f)Tj /Span<>> BDC ( )Tj EMC (\023\024\n\024\013\034\033 \r\036\027\036\023\031\027\022\006\017\017 )Tj 0.3 Tw T* (\026\002\017\030\026\035\017 25 \n\035 \r\036\027\024\027\024\005 \022\ \030\024\r\017. \025\030\024\r\034 \024\021\002\017\030\026\035\017 )Tj 0.058 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (7)Tj /Span<>> BDC ( )Tj EMC (\004\017\f\021\t\b \r\026\022\031\031\n\027\t\b \023\030\024\002\017\030\ \024\022 \024\002\255\036\n\024\n 4)Tj /Span<>> BDC ( )Tj EMC (\n\035, \022\024\021\024)Tj 0 Tw (-)Tj 0.062 Tw T* [(\030\t\036 )0.5(\f\024\007\036\030\032\026\035\017 )0.6(3,8% )0.5(\030\026\f\021\r\024\030 )0.5(\006\017\021\030\026\021\026 )0.5(\027\026\021\030\017\016 )0.6(\r)]TJ /Span<>> BDC ( )Tj EMC 19.897 0 Td (\022\026\004\036)Tj 0 Tw (-)Tj 0.162 Tw -19.897 -1.218 Td (\f\021\r\036 \026\027\021\017\022\024\026\020\031\035\016\027\021\026. \003\ \026\021\036\n \006\017\021\030\026\021\017\030\024\r\026\027\027\031\033\ \022\030\024\r\034 )Tj -0.015 Tw T* (\006\036\027\021\030\017\235\031\020\017\030\024\r\026\035\017 \023\030\017\ )Tj /Span<>> BDC ( )Tj EMC (1700 \024\002/\n\017\027 \r)Tj /Span<>> BDC ( )Tj EMC (\021\036\004\036\027\017\036 15)Tj /Span<>> BDC ( )Tj EMC (\n\017)Tj 0 Tw (-)Tj 0.172 Tw T* (\027\031\021 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\022\024\n\027\026\021\027\024\005 \021\036\n\023\036\030\026\021\031\030\ \036, \024\021\007\036\035\016\016 \220\030\017\021\030\024\006\017)Tj 0 Tw (-)Tj 0.182 Tw T* (\021\t \r\027\017\031, \023\035\026\n\031 \r\r\036\030\b\031 \017)Tj /Span<>> BDC ( )Tj EMC (\253\024\b\030\017\f\021\t\005 \f\035\024\005\273 \n\036\032\007\031 )Tj 0.127 Tw T* (\027\017\n\017. \215\035\026\n\031 \017)Tj /Span<>> BDC ( )Tj EMC (\253\024\b\030\017\f\021\t\005 \f\035\024\005\273 \r\t\007\036\035\016\035\ \017 \017)Tj /Span<>> BDC ( )Tj EMC (\022\026\032)Tj 0 Tw (-)Tj 0.305 Tw T* [(\007\024\005 \023\030\024\002\017\030\022\017 )0.5(\023\030\017)]TJ /Span<>> BDC ( )Tj EMC [(\023\024\n\024\013\017 )0.5(\001\023\030\017\006\026 \017)]TJ /Span<>> BDC ( )Tj EMC 17.214 0 Td (\023\036\030\036\027\024\f\017\035\017 )Tj 0.182 Tw -17.214 -1.218 Td (\r)Tj /Span<>> BDC ( )Tj EMC (\007\030\031\020\031\033 \023\030\024\002\017\030\022\031, \026\021\036\ \n \f\027\024\r\026 \006\036\027\021\030\017\235\031\020\017\030\024\r\026\ \035\017 )Tj 0.07 Tw 23.244 64.543 Td (\023\030\017)Tj /Span<>> BDC ( )Tj EMC (3000)Tj /Span<>> BDC ( )Tj EMC (\024\002/\n\017\027 \r)Tj /Span<>> BDC ( )Tj EMC (\021\036\004\036\027\017\036 10 \n\017\027\031\021 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\022\024\n\027\026\021\027\024\005 )Tj 0.647 Tw 0 -1.218 TD [(\021\036\n\023\036\030\026\021\031\030\036. )0.6(\215\024\f\035\036 )0.5(\r\021\024\030\024\020\024 )0.5(\006\036\027\021\030\017\235\031\020\017\030\024\r\026\027\017\016 )]TJ 0.104 Tw 0 -1.218 TD (\002\t\035\017 \023\024\035\031\004\036\027\t \007\r\026 \021\017\023\026\ \023\035\026\n\t: \r\036\030\b\027\016\016 \004\026\f\021\034, \f\024)Tj 0 Tw (-)Tj 0.1 Tw 0 -1.218 TD [(\007\036\030\032\026\013\026\016 )0.6(\023\035\026\n\031 )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC 8.513 0 Td [(\027\017\022\017\n )0.6(\f\024\007\036\030\032\026\027\017\036\n )0.5(\021\030\024\n\002\024\006\017)]TJ 0 Tw (-)Tj 0.034 Tw -8.513 -1.218 Td (\021\024\r \(PPP\), \017)Tj /Span<>> BDC ( )Tj EMC (\027\017\032\027\016\016 \004\026\f\021\034, \f\024\007\036\030\032\026\013\ \026\016 \023\035\026\n\031, \002\024\020\026)Tj 0 Tw (-)Tj 0.037 Tw 0 -1.218 TD (\021\031\033 \021\030\024\n\002\024\006\017\021\026\n\017 \(PRP\). PPP \021\ \013\026\021\036\035\034\027\024 \024\021\007\036\035\016\035\017 \024\021\ )Tj -0.006 Tw 0 -1.218 TD [(PRP. )0.5(\203\026)]TJ /Span<>> BDC ( )Tj EMC [(4 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC [(12 )0.5(\f\031\021\022\017 )0.5(\023\024\f\035\036 \023\030\024\r\036\007\036\027\017\016 )0.5(\024\023\036\030\026\006\017\024\027\027\024)]TJ 0 Tw (-)Tj 0.117 Tw 0 -1.218 TD (\020\024 \r\n\036\001\026\021\036\035\034\f\021\r\026 \r)Tj /Span<>> BDC ( )Tj EMC (\024\002\255\036\n\036 \017\f\f\036\004\036\027\017\016 \225\025\216 PRP\ \r\r\024)Tj 0 Tw (-)Tj 0.021 Tw T* (\007\017\035\017 \r)Tj /Span<>> BDC ( )Tj EMC (\023\024\f\035\036\024\023\036\030\026\006\017\024\027\027\031\033 \030\026\ \027\031 \004\036\030\036 \020\030\026\027\031\035\016\006\017\024\027)Tj 0 Tw (-)Tj 0.033 Tw T* (\027\031\033 \021\022\026\027\034 \027\026)Tj /Span<>> BDC ( )Tj EMC (\020\035\031\002\017\027\031 13 \n\n \f)Tj /Span<>> BDC ( )Tj EMC (\023\024\n\024\013\034\033 \017\027\f\031\035\017\027\024\r\024\005 )Tj 0.078 Tw T* (\017\020\035\t \(0,1 \n\035/\f\n)Tj 0 Tw 5.83 0 0 5.83 341.49 606.3798 Tm (2)Tj 0.078 Tw 10 0 0 10 344.405 603.0498 Tm (\), \023\024\f\035\036 \004\036\020\024 \030\026\027\031 \026\023\024\035\ \027\016\035\017 \024\f\021\026\r)Tj 0 Tw (-)Tj 0.561 Tw -6.944 -1.218 Td (\001\036\005\f\016 \026\031\021\024\023\035\026\n\024\005, \024\002\024\ \020\026\013\036\027\027\024\005 \021\030\024\n\002\024\006\017\021\026\n\ \017. )Tj 0.4 Tw T* (\210\002\030\026\002\024\021\026\027\027\031\033 \023\024\f\035\036\024\023\ \036\030\026\006\017\024\027\027\031\033 \030\026\027\031 \017\024\035\017\ \030\024)Tj 0 Tw (-)Tj 0.057 Tw T* (\r\026\035\017 \024\021 \027\036\023\024\r\030\036\032\007\036\027\027\t\ \b \021\022\026\027\036\005 \f)Tj /Span<>> BDC ( )Tj EMC (\006\036\035\034\033 \023\030\036\007\024\021\r\030\026)Tj 0 Tw (-)Tj 0.01 Tw T* (\013\036\027\017\016 \r\t\021\036\022\026\027\017\016 PRP \f)Tj /Span<>> BDC ( )Tj EMC (\017\f\023\024\035\034\024\r\026\027\017\036\n \f\021\036\030\017\035\034\ \027\024\020\024 )Tj 0.055 Tw T* (\027\036 \026\035\035\036\030\020\036\027\027\024\020\024 \035\026\021\036\ \022\f\026 \027\026 24 \004\026\f\026. \232\036\030\036 \f\031\021\022\017\ \035\026)Tj 0 Tw (-)Tj 0.126 Tw T* (\021\036\022\f\027\024\036 \023\024\022\030\t\021\017\036 \f\027\017\n\026\ \035\017 \017)Tj /Span<>> BDC ( )Tj EMC (\027\026\022\035\026\007\t\r\026\035\017 \024\002\t\004\027\031\033 )Tj 0 Tw T* (\023\024\r\016\022\031.)Tj 0.129 Tw T* (\202\031\021\024\023\035\026\n\026, \024\002\024\020\026\013\036\027\027\ \026\016 \021\030\024\n\002\024\006\017\021\026\n\017, \r)Tj /Span<>> BDC ( )Tj EMC (\017\f\f\035\036\007\024)Tj 0 Tw (-)Tj -0.001 Tw T* (\r\026\027\017\017 Boztug)Tj /Span<>> BDC ( )Tj EMC (C.Y. \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. [6] \020\024\021\024\r\017\035\026\f\034 \f\035\036\007\ \031\033\013\017\n )Tj -0.05 Tw T* [(\024\002\030\026\024\n: )0.5(\031)]TJ /Span<>> BDC ( )Tj EMC [(\023\026\006\017\036\027\021\026 )0.5(\r\t\023\024\035\027\016\035\017 )0.5(\026\002\024\030 \022\030\024\r\017 \024\002\255\036\n\024\n )]TJ 0.18 Tw T* (450 \f\n)Tj 0 Tw 5.83 0 0 5.83 304.172 472.4218 Tm (3)Tj 0.18 Tw 10 0 0 10 307.087 469.0918 Tm ( \r)Tj /Span<>> BDC ( )Tj EMC (\007\036\027\034 \024\023\036\030\026\006\017\017. \212\035\016 \030\026\ \007\036\035\036\027\017\016 \006\036\035\034\027\024\005 )Tj 0.163 Tw -3.213 -1.218 Td (\022\030\024\r\017 \027\026)Tj /Span<>> BDC ( )Tj EMC (\036\036 \022\024\n\023\024\027\036\027\021\t \017\f\023\024\035\034\024\ \r\026\035\017 \n\036\021\024\007 \007\r\031\b)Tj 0 Tw (-)Tj 0.197 Tw T* (\f\021\031\023\036\027\004\026\021\024\020\024 \006\036\027\021\030\017\235\ \031\020\017\030\024\r\026\027\017\016. \203\026)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\r\024\n \220\021\026\023\036 )Tj 0.168 Tw T* (\023\035\026\n\031 \024\021\007\036\035\016\035\017 \024\021 \022\024\027\ \006\036\027\021\030\026\021\026 \220\030\017\021\030\024\006\017\021\024\ \r \f)Tj /Span<>> BDC ( )Tj EMC (\023\024)Tj 0 Tw (-)Tj 0.171 Tw T* (\n\024\013\034\033 \027\017\022\024\f\022\024\030\024\f\021\027\024\020\ \024 \006\036\027\021\030\017\235\031\020\017\030\024\r\026\027\017\016 \ \r)Tj /Span<>> BDC ( )Tj EMC (\026\023)Tj 0 Tw (-)Tj 0.17 Tw T* [(\023\026\030\026\021\036 Her)-33(aeus Cr)-24(yofuge \(22\263C, 2500 \024\002/\n\017\027, 7)]TJ /Span<>> BDC ( )Tj EMC (\n\017)Tj 0 Tw (-)Tj 0.17 Tw T* (\027\031\021\). \215\024\f\035\036 \004\026\f\024\r\024\020\024 \023\036\ \030\017\024\007\026 \024\032\017\007\026\027\017\016 \027\026\004\017\027\ \026\035\f\016 )Tj 0.06 Tw T* (\r\021\024\030\024\005 \220\021\026\023, \r\024 \r\030\036\n\016 \022\024\ \021\024\030\024\020\024 PRP \024\021\007\036\035\016\035\017 \024\021 P\ PP )Tj 0.233 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\023\024\n\024\013\034\033 \r\t\f\024\022\024\f\022\024\030\024\f\021\027\ \024\020\024 \006\036\027\021\030\017\235\031\020\017\030\024\r\026\027\017\ \016 )Tj -0.009 Tw T* (\(22\263C, 3200 \024\002/\n\017\027, 15 \n\017\027\031\021\). \215\024\035\ \031\004\036\027\027\t\005 \r)Tj /Span<>> BDC ( )Tj EMC (\030\036\031\035\034)Tj 0 Tw (-)Tj 0.074 Tw T* (\021\026\021\036 \r\021\024\030\024\020\024 \006\036\027\021\030\017\235\ \031\020\017\030\024\r\026\027\017\016 PRP \023\036\030\036\n\036\001\017\ \r\026\035\017 )Tj -0.022 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC 1.185 0 Td [(\n\036\001\026\035\022\036 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC [(\021\036\004\036\027\017\036 )0.5(1 )0.5(\004\026\f\026 \017)]TJ /Span<>> BDC ( )Tj EMC 11.442 0 Td [(\030\026\007\036\035\016\035\017 )0.5(\027\026)]TJ /Span<>> BDC ( )Tj EMC 5.689 0 Td [(\023\016\021\034 )0.5(\030\026\r)]TJ 0 Tw (-)Tj 0.03 Tw -18.316 -1.218 Td (\027\t\b \004\026\f\021\036\005 \f)Tj /Span<>> BDC ( )Tj EMC (\023\024\n\024\013\034\033 \f\021\036\030\017\035\034\027\024\020\024 \f\ \024\036\007\017\027\017\021\036\035\034\027\024\020\024 )Tj 0.04 Tw T* (\031\f\021\030\024\005\f\021\r\026. PRP \b\030\026\027\017\035\017 \023\030\ \017)Tj /Span<>> BDC ( )Tj EMC (\021\036\n\023\036\030\026\021\031\030\036 25\263C \f)Tj /Span<>> BDC ( )Tj EMC (\023\036)Tj 0 Tw (-)Tj 0.177 Tw T* (\030\036\n\036\001\017\r\026\027\017\036\n. \203\036\024\002\b\024\007\017\ \n\024 \024\021\n\036\021\017\021\034, \004\021\024 \f\024\020\035\026\f\ \027\024 )Tj 0.221 Tw T* [(\253\203\026\006\017\024\027\026\035\034\027\t\n )0.6(\030\036\022\024\n\036\027\007\026\006\017\016\n )0.5(\023\024)]TJ /Span<>> BDC ( )Tj EMC 15.534 0 Td (\023\030\017\020\024\021\024\r\035\036\027\017\033, )Tj 0.119 Tw -15.534 -1.218 Td (\017\f\023\024\035\034\024\r\026\027\017\033 \017)Tj /Span<>> BDC ( )Tj EMC (\024\002\036\f\023\036\004\036\027\017\033 \022\026\004\036\f\021\r\026 \ \022\030\024\r\017 \017)Tj /Span<>> BDC ( )Tj EMC (\036\036 )Tj 0.006 Tw T* (\022\024\n\023\024\027\036\027\021\024\r\273, \021\030\036\002\024\r\026\ \027\017\016 \022)Tj /Span<>> BDC ( )Tj EMC (\024\002\024\020\026\013\036\027\027\024\005 \021\030\024\n\002\024\006\017\ )Tj 0 Tw (-)Tj 0.116 Tw T* (\021\026\n\017 \023\035\026\n\036 \r\022\035\033\004\026\033\021 \n\017\ \027\017\n\026\035\034\027\t\005 \024\002\255\036\n \r)Tj /Span<>> BDC ( )Tj EMC (40)Tj /Span<>> BDC ( )Tj EMC (\n\035 )Tj 0.305 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\n\017\027\017\n\026\035\034\027\024\036 \022\024\035\017\004\036\f\021\r\ \024 \021\030\024\n\002\024\006\017\021\024\r \r)Tj /Span<>> BDC ( )Tj EMC (\036\007\017\027\017)Tj 0 Tw (-)Tj 0.078 Tw T* (\006\036)Tj /Span<>> BDC ( )Tj EMC (\227 6)Tj /Span<>> BDC ( )Tj EMC (\327)Tj /Span<>> BDC ( )Tj EMC (10)Tj 0 Tw 5.83 0 0 5.83 327.1034 228.8618 Tm (10)Tj 0.078 Tw 10 0 0 10 332.9334 225.5318 Tm ( [12], \026)Tj /Span<>> BDC ( )Tj EMC (\n\026\022\f\017\n\026\035\034\027\024\036 \022\024\035\017\004\036\f\021\ \r\024 \035\036\005)Tj 0 Tw (-)Tj 0.223 Tw -5.797 -1.218 Td (\022\024\006\017\021\024\r)Tj /Span<>> BDC ( )Tj EMC (\227 0,2)Tj /Span<>> BDC ( )Tj EMC (\327)Tj /Span<>> BDC ( )Tj EMC (10 \n\022\020/\036\007. [13]. PRP \027\026\027\024\f\017\035\026\f\034 )Tj 0.101 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC (\030\026\027\031 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\023\024\n\024\013\017 \001\023\030\017\006\026 \f\030\026\031 \023\024\ \f\035\036 \024\023\036\030\026\006\017\017. )Tj 0.1 Tw T* (\215\024\f\035\036 \027\026\027\036\f\036\027\017\016 \023\035\026\n\t,\ \024\002\024\020\026\013\036\027\027\024\005 \021\030\024\n\002\024\006\ \017\021\026)Tj 0 Tw (-)Tj 0.008 Tw T* (\n\017, \r\021\024\030\031\033 \007\024\031 \027\026\027\024\f\017\035\017\ \004\036\030\036 48 \004\026\f\024\r, \007\026\035\036\036 \027\026)Tj /Span<>> BDC ( )Tj EMC (3, )Tj 0 Tw T* (4 \017)Tj /Span<>> BDC ( )Tj EMC (5 \007\027\017 \023\024\f\035\036 \r\n\036\001\026\021\036\035\034\f\021\ \r\026.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 275.0305 128.1078 Tm [(\033\034\020)21(\223)50(\r\237)46(\024)52(\026)45(\024\232)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0 Tc 0.005 Tw 10 0 0 10 274.9606 103.7518 Tm [(\215\030\024\026\027\026\035\017\017\030\024\r\026\027\t )0.5(\007\026\027\027\t\036 )0.5(\024)]TJ /Span<>> BDC ( )Tj EMC [(299 \023\026\006\017\036\027\021\026\b, )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 19.917 0 Td (\022\024\021\024)Tj 0 Tw (-)Tj -0.036 Tw -19.917 -1.218 Td (\030\t\b 142)Tj /Span<>> BDC ( )Tj EMC (\(47,5%\) \023\024\035\031\004\026\035\017 \035\036\004\036\027\017\036 \ \r)Tj /Span<>> BDC ( )Tj EMC (\024\002\255\036\n\036 \017\024\035\017\030\024)Tj 0 Tw (-)Tj -0.041 Tw T* (\r\026\027\027\024\020\024 \017\f\f\036\004\036\027\017\016 \225\025\216\ \f)Tj /Span<>> BDC ( )Tj EMC (\024\021\022\030\t\021\t\n \f\023\024\f\024\002\024\n \r\036\007\036\027\ \017\016 )Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 0 Tw 7.5 0 0 7.5 42.5197 759.8869 Tm [(\007\003\032)50(\n\n\217\n)-21(\035\030\002)]TJ 53.418 0 Td [(MET)30(A)-41(-)-41.9(ANAL)30(Y)30(SIS)]TJ /T1_3 1 Tf 25 0 0 25 505.5646 56.0378 Tm (143)Tj ET endstream endobj 1467 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.446 Tw 10 0 0 10 379.0002 724.8299 Tm (\215\r\003\002\240\t\220\004 \002\212\006\r\240\r\f\r\b\t\235 \002\206\234\ \r\214\004 )Tj 0 Tw 0 -1.218 TD (\006\004\b\r\002\n\002 \240\r\233\r\220\003\004)Tj /T1_1 1 Tf 0.322 Tw T* (\224\030\026\031 \023\024\f\035\036 \r\t\023\024\035\027\036\027\017\016\ \017\f\f\036\004\036)Tj 0 Tw (-)Tj 0.142 Tw T* (\027\017\016 \225\025\216 \023\024\f\035\036\024\023\036\030\026\006\017\ \024\027\027\031\033 \030\026\027\031 )Tj 0.386 Tw T* (\026\023\024\035\027\016\035\017 0,9% \030\026\f\021\r\024\030\024\n Na\ Cl)Tj 0 Tw 5.83 0 0 5.83 521.4944 674.1179 Tm (2)Tj 10 0 0 10 524.4094 676.1179 Tm ( )Tj 0.359 Tw -14.541 -1.218 Td (\007\024)Tj /Span<>> BDC ( )Tj EMC (\022\024\032\027\t\b \022\030\026\036\r. \215\031\021\036\n \026\002\024\ \030\026 )Tj 0.454 Tw T* (\032\017\007\022\024\f\021\017 \017)Tj /Span<>> BDC ( )Tj EMC (\030\026\027\t \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\023\024\n\024\013\017 )Tj 0.167 Tw 0 -1.218 TD (\001\023\030\017\006\026 \017\n\036\030\016\035\017 \024\002\255\036\n \ \026\023\024\035\027\016)Tj 0 Tw (-)Tj 0.076 Tw 0 -1.218 TD (\033\013\036\020\024 \023\024\035\024\f\021\034 \030\026\f\021\r\024\030\ \026, \004\021\024 \017)Tj /Span<>> BDC ( )Tj EMC (\016\r)Tj 0 Tw (-)Tj 0.238 Tw 0 -1.218 TD [(\035\016\035\024\f\034 )0.5(\024\002\255\036\n\024\n )0.5(\023\024\f\035\036\024\023\036\030\026\006\017\024\027)]TJ 0 Tw (-)Tj 0 -1.218 TD (\027\024\005 \030\026\027\t [3\2266].)Tj /T1_0 1 Tf 0.182 Tw 0 -2.436 TD (\215\r\003\002\240\t\220\004 \212\006\t\n\002\003\002\f\r\b\t\235 \t)Tj /Span<>> BDC ( )Tj EMC (\r)Tj 0 Tw (-)Tj 0 -1.218 TD (\240\r\b\t\235 PRP)Tj /T1_1 1 Tf 0.272 Tw 0 -1.218 TD (\215\026\006\017\036\027\021\026\n \020\030\031\023\023\t \n\036\f\021\027\ \024\020\024 \023\030\017)Tj 0 Tw (-)Tj 0.185 Tw 0 -1.218 TD (\n\036\027\036\027\017\016 PRP \r)Tj /Span<>> BDC ( )Tj EMC (\f\024\004\036\021\026\027\017\017 \f)Tj /Span<>> BDC ( )Tj EMC (\017\f\f\036)Tj 0 Tw (-)Tj 0.169 Tw 0 -1.218 TD (\004\036\027\017\036\n \225\025\216 \f)Tj /Span<>> BDC ( )Tj EMC (\024\021\022\030\t\021\t\n \f\023\024\f\024\002\024\n )Tj 0.261 Tw 0 -1.218 TD (\r\036\007\036\027\017\016 \030\026\027\t, \r\022\035\033\004\036\027\027\ \t\b \r)Tj /Span<>> BDC ( )Tj EMC (\017\f)Tj 0 Tw (-)Tj 0.17 Tw 0 -1.218 TD [(\f\035\036\007\024\r\026\027\017\036 )0.5(Spyr)-36.9(id)42(ak)-16(is )0.5(\204. )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. )Tj 0.04 Tw 0 -1.218 TD ([4], \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\023\024\n\024\013\017 \r\036\027\036\023\031\027\022\006\017\017 \023\030\ \024)Tj 0 Tw (-)Tj 0.488 Tw 0 -1.218 TD (\017\r\024\007\017\035\017 \026\002\024\030 \022\030\024\r\017 \024\002\ \255\036\n\024\n )Tj 0.183 Tw 0 -1.218 TD (27)Tj /Span<>> BDC ( )Tj EMC (\n\035 \f)Tj /Span<>> BDC ( )Tj EMC [(\006\036\035\034\033 \023\024\035\031\004\036\027\017\016 )0.5(\220\235\235\036\022)]TJ 0 Tw (-)Tj 0.516 Tw 0 -1.218 TD [(\021\017\r\027\024\020\024 )0.5(\022\024\035\017\004\036\f\021\r\026 )0.5(\022\024\027\006\036\027\021\030\026\021\026 )]TJ 0.749 Tw T* [(\021\030\024\n\002\024\006\017\021\024\r )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC 7.739 0 Td (\017\f\023\024\035\034\024\r\026\027\017\036\n )Tj 0.428 Tw -7.739 -1.218 Td [(\f\017\f\021\036\n\t )0.5(\020\030\026\r\017\021\026\006\017\024\027\027\024\020\024 )0.5(\030\026\007\036)]TJ 0 Tw (-)Tj -0.02 Tw 0 -1.218 TD [(\035\036\027\017\016 \021\030\024\n\002\024\006\017\021\024\r \(GPS )0.5(II\). \200)]TJ /Span<>> BDC ( )Tj EMC (\023\030\024)Tj 0 Tw (-)Tj 0.008 Tw 0 -1.218 TD (\002\017\030\022\031 \f)Tj /Span<>> BDC ( )Tj EMC (\f\017\f\021\036\n\024\005 GPS II \007\024\002\026\r\035\016\035\017 )Tj 0.196 Tw 0 -1.218 TD (3)Tj /Span<>> BDC ( )Tj EMC (\n\035 \026\027\021\017\022\024\026\020\031\035\016\027\021\026 \017)Tj /Span<>> BDC ( )Tj EMC (\006\036\027\021\030\017\235\031)Tj 0 Tw (-)Tj 0.263 Tw 0 -1.218 TD (\020\017\030\024\r\026\035\017 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (3200)Tj /Span<>> BDC ( )Tj EMC [(\024\002/\n\017\027 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC (\021\036)Tj 0 Tw (-)Tj 0.158 Tw 0 -1.218 TD (\004\036\027\017\036 15)Tj /Span<>> BDC ( )Tj EMC (\n\017\027\031\021. \003\026\023\026\021\036\027\021\024\r\026\027\027\t\ \005 )Tj -0.024 Tw 0 -1.218 TD (\007\r\024\005\027\024\005 \002\031\005 GPS II \027\026\f\021\030\024\036\ \027 \027\026)Tj /Span<>> BDC ( )Tj EMC (\017)Tj 0 Tw (-)Tj 0.516 Tw 0 -1.218 TD [(\n\036\030\036\027\017\036 )0.5(\023\035\024\021\027\024\f\021\017 )0.5(\021\030\024\n\002\024\006\017\021\024\r )]TJ 0.626 Tw 0 -1.218 TD (\017)Tj /Span<>> BDC ( )Tj EMC (\220\030\017\021\030\024\006\017\021\024\r. \215\024\007 \007\036\005\f\021\ \r\017\036\n )Tj 0.321 Tw 0 -1.218 TD (\006\036\027\021\030\024\002\036\032\027\024\005 \f\017\035\t \002\031\017\ \253\r\f\023\035\t)Tj 0 Tw (-)Tj 0.385 Tw 0 -1.218 TD [(\r\026\033\021\273 )0.5(\r\027\031\021\030\017 )0.5(\023\030\024\002\017\030\022\017 )0.5(\022)]TJ /Span<>> BDC ( )Tj EMC 12.241 0 Td (\n\036\f\021\031 )Tj 0.914 Tw -12.241 -1.218 Td (\017\n\036\027\036\027\017\016 \023\035\024\021\027\024\f\021\017, \f\024\ \002\017\030\026\016 )Tj 0.099 Tw 0 -1.218 TD (\017)Tj /Span<>> BDC ( )Tj EMC (\031\007\036\030\032\017\r\026\016 \002\024\020\026\021\t\005 \021\030\024\ \n\002\024\006\017\021\026)Tj 0 Tw (-)Tj 0.086 Tw 0 -1.218 TD (\n\017 \f\035\024\005 \n\036\032\007\031 \027\017\032\027\017\n \017)Tj /Span<>> BDC ( )Tj EMC (\r\036\030\b\027\017\n )Tj 0.206 Tw 0 -1.218 TD [(\002\031\016\n\017. )0.5(\224\017\f\021\036\n\026 )0.5(GPS )0.5(II )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC 10.999 0 Td [(\036\036 )0.5(\026\r\021\024)]TJ 0 Tw (-)Tj 0.11 Tw -10.999 -1.218 Td [(\n\026\021\017\017\030\024\r\026\027\027\t\n )0.6(\023\030\024\006\036\f\f\024\n )0.5(\f\002\024\030\026 )]TJ 0.582 Tw 0 -1.218 TD [(\021\030\024\n\002\024\006\017\021\024\r )0.5(\030\026\030\026\002\024\021\026\027\026 )0.6(\021\026\022\017\n )]TJ 0.559 Tw 0 -1.218 TD (\024\002\030\026\024\n, \004\021\024\002\t \024\002\036\f\023\036\004\017\ \021\034 \023\024)Tj 0 Tw (-)Tj 0.284 Tw 0 -1.218 TD (\f\021\024\016\027\027\024\036 \002\026\024\r\024\036 8-\022\030\026\021\ \027\024\036 \031\r\036)Tj 0 Tw (-)Tj 0.333 Tw 0 -1.218 TD [(\035\017\004\036\027\017\036 )0.5(\022\024\035\017\004\036\f\021\r\026 )0.5(\021\030\024\n\002\024\006\017\021\024\r )]TJ 0.207 Tw 0 -1.218 TD (\r)Tj /Span<>> BDC ( )Tj EMC (\024\002\024\020\026\013\036\027\027\024\005 \023\035\026\n\036 \023\030\ \017)Tj /Span<>> BDC ( )Tj EMC (\024\007\027\024)Tj 0 Tw (-)Tj 0.135 Tw 0 -1.218 TD (\r\030\036\n\036\027\027\024\n \f\002\024\030\036 \002\024\035\036\036 8\ 0% \017\n\036)Tj 0 Tw (-)Tj 0.379 Tw 0 -1.218 TD (\033\013\017\b\f\016 \021\030\024\n\002\024\006\017\021\024\r \r)Tj /Span<>> BDC ( )Tj EMC (\024\002\030\026\006\036. )Tj 0.14 Tw 0 -1.218 TD (\213\013\036 6 \n\035 \022\030\024\r\017 \023\026\006\017\036\027\021\026\ \006\036\027\021\030\017)Tj 0 Tw (-)Tj 0.78 Tw 0 -1.218 TD (\235\031\020\017\030\024\r\026\035\017 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (3200)Tj /Span<>> BDC ( )Tj EMC (\024\002/\n\017\027 )Tj 0.179 Tw 0 -1.218 TD (\r)Tj /Span<>> BDC ( )Tj EMC (\021\036\004\036\027\017\036 2)Tj /Span<>> BDC ( )Tj EMC (\n\017\027\031\021 \007\035\016 \023\024\035\031\004\036\027\017\016 )Tj 0.071 Tw 0 -1.218 TD (\021\030\024\n\002\017\027\026. \215\030\017)Tj /Span<>> BDC ( )Tj EMC (\f\n\036\001\017\r\026\027\017\017 \f)Tj /Span<>> BDC ( )Tj EMC (\020\035\033)Tj 0 Tw (-)Tj 0.329 Tw 0 -1.218 TD (\022\024\027\026\021\024\n \022\026\035\034\006\017\016 \021\030\024\n\002\ \017\027 \f\021\026\027\024)Tj 0 Tw (-)Tj 0.199 Tw 0 -1.218 TD (\r\017\021\f\016 \n\024\013\027\t\n \026\022\021\017\r\026\021\024\030\024\ \n \021\030\024\n)Tj 0 Tw (-)Tj 1.072 Tw 0 -1.218 TD (\002\024\006\017\021\024\r. \236\f\023\024\035\034\024\r\026\035\017 \n\ \036\021\024\007 )Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 0.013 Tw 0 9 -9 0 77.3911 79.3701 Tm (\020\004\206\f\t\204\004 1.)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf ( \212\037\033\037\021\035\016\033\022\024\035\022\021\037 \022\024\024\027\ \016\b\034\036\037\020\022\004, \024\033\037\036\020\022\036\037\026\235\ \022\002 \006\016\024\035\020\034\016 \f\033\022\006\016\020\016\020\022\ \016 \037\023\035\034\f\027\037\031\006\032, \025\034\013\037\035\034\004\ \035\033\034\006\025\034\007\022\035\037\006\022, \036)Tj /Span<>> BDC ( )Tj EMC (\024\034\005\016\035\037\020\022\022 \024)Tj /Span<>> BDC ( )Tj EMC (\022\024\024\016\005\016\020\022\016\006 \220\f\022\035\016\027\022\037\027\ \003\020\034\013\034 \021\034\f\005\022\021\034\036\034\013\034 )Tj 0.011 Tw 0 -1.2 TD (\002\034\b\037 \024)Tj /Span<>> BDC ( )Tj EMC (\034\035\021\033\032\035\032\006 \024\f\034\024\034\025\034\006 \036\016\ \b\016\020\022\030 \033\037\020\032 \022)Tj /Span<>> BDC ( )Tj EMC (\022\031\034\027\022\033\034\036\037\020\020\034\013\034 \022\024\024\016\ \005\016\020\022\030 \220\f\022\035\016\027\022\037\027\003\020\034\013\034\ \021\034\f\005\022\021\034\036\034\013\034 \002\034\b\037 \024)Tj /Span<>> BDC ( )Tj EMC (\034\035\021\033\032\035\032\006 \024\f\034\024\034\025\034\006 \036\016\ \b\016\020\022\030 \033\037\020\032 \b\027\030 \027\016\005\016\020\022\030\ \f\037\007\022\016\020\035\034\036 \024)Tj /Span<>> BDC ( )Tj EMC (\002\033\034\020\022)Tj 0 Tw (-)Tj T* (\005\016\024\021\022\006 \036\034\024\f\037\027\016\020\022\016\006 \220\ \f\022\035\016\027\022\037\027\003\020\034\013\034 \021\034\f\005\022\021\ \034\036\034\013\034 \002\034\b\037)Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf -0.027 Tc 0.078 Tw T* [(T)0.5(a)-35.3(b)-40.7(l)-38.7(e)-27( 1)-24.5(.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf 0 Tc 0.051 Tw 3.375 0 Td [( C)-1.1(ha)-4.2(r)3.4(a)-9.2(c)-32.4(t)-1.6(e)-6(r)-39(i)6.6(s)-14.8(t)-29.1(i)-1.8(c)-26.6(s o)4(f)]TJ /Span<>> BDC ( )Tj EMC [(s)-14.8(t)-1.1(u)-5.9(d)-3(i)-1.4(e)-22(s c)2.8(o)-4(m)-1(p)-6.3(a)-4.2(r)-39(i)4(n)-0.6(g t)-10.6(h)-2.4(e)]TJ /Span<>> BDC ( )Tj EMC [(l)-1.1(a)-10.1(y)]TJ /Span<>> BDC ( )Tj EMC [(\227 o)-5.3(p)-11.3(e)-7(n m)-5.3(e)-8.6(t)-10.6(h)-2.4(o)-12(d w)-26.7(i)-3.4(t)-10.6(h t)-10.6(h)-2.4(e)]TJ /Span<>> BDC ( )Tj EMC [(u)-4.4(s)0.5(e o)4(f)]TJ /Span<>> BDC ( )Tj EMC [(p)-4.9(l)-1.1(a)-9.1(t)-1.6(e)-6.1(le)-8.6(t)]TJ /Span<>> BDC ( )Tj EMC [(\227 r)-39(i)-1.8(c)-2.5(h a)-2.5(u)-4.8(t)-3(o)-5.3(p)-4.9(l)-1.1(a)-7.2(s)5.1(ma t)-3(o)]TJ /Span<>> BDC ( )Tj EMC [(t)-10.6(h)-2.4(e l)-1.1(a)-10(y)]TJ /Span<>> BDC ( )Tj EMC [(\227 o)-5.2(p)-11.3(e)-7(n m)-5.3(e)-8.6(t)-10.6(h)-2.4(o)-11.9(d w)-26.7(i)-3.4(t)-10.6(h)-2.4(o)-3.4(u)-4.7(t u)-4.4(s)-12.5(i)3.9(n)-0.6(g p)-4.9(l)-1.1(a)-9.2(t)-1.6(e)-6.1(le)-8.5(t)]TJ /Span<>> BDC ( )Tj EMC [(\227 r)-38.9(i)-1.8(c)-2.5(h p)-4.9(l)-1.1(a)-7.2(s)5.1(ma f)-13.4(o)-3(r )]TJ 0 Tw -3.375 -1.2 Td [(t)-10.6(h)-2.4(e)]TJ /Span<>> BDC ( )Tj EMC [(t)-9.6(r)-1.9(e)-7.6(a)-9.1(t)-10.6(m)-5.3(e)-7(n)-0.6(t o)4(f)]TJ /Span<>> BDC ( )Tj EMC [(p)1.4(i)2.9(l)-1.6(o)-4(n)1.7(i)-1.4(d)-2.5(a)-4.5(l d)-2.9(i)6.6(s)0.5(e)-7.5(a)-7.2(s)0.5(e)]TJ ET 0 0 0 1 K 0.5 w /GS2 gs q 1 0 0 1 123.6757 79.3701 cm 0 0 m 0 41.567 l S Q q 1 0 0 1 192.4949 79.6201 cm 0 0 m -68.569 0 l S Q q 1 0 0 1 123.6757 120.9372 cm 0 0 m 0 19.843 l S Q q 1 0 0 1 192.4949 120.9372 cm 0 0 m -68.569 0 l S Q q 1 0 0 1 123.6757 140.7797 cm 0 0 m 0 25.512 l S Q q 1 0 0 1 192.4949 140.7797 cm 0 0 m -68.569 0 l S Q q 1 0 0 1 123.6757 166.2915 cm 0 0 m 0 19.843 l S Q q 1 0 0 1 192.4949 166.2915 cm 0 0 m -68.569 0 l S Q q 1 0 0 1 123.6757 186.134 cm 0 0 m 0 25.512 l S Q q 1 0 0 1 192.4949 186.134 cm 0 0 m -68.569 0 l S Q q 1 0 0 1 123.6757 211.6458 cm 0 0 m 0 37.599 l S Q q 1 0 0 1 192.4949 211.6458 cm 0 0 m -68.569 0 l S Q q 1 0 0 1 123.6757 249.2448 cm 0 0 m 0 25.512 l S Q q 1 0 0 1 192.4949 249.2448 cm 0 0 m -68.569 0 l S Q q 1 0 0 1 123.6757 274.7566 cm 0 0 m 0 16.615 l S Q q 1 0 0 1 192.4949 274.7566 cm 0 0 m -68.569 0 l S Q q 1 0 0 1 123.6757 291.3719 cm 0 0 m 0 22.115 l S Q q 1 0 0 1 192.4949 291.3719 cm 0 0 m -68.569 0 l S Q q 1 0 0 1 123.6757 313.4867 cm 0 0 m 0 39.685 l S Q q 1 0 0 1 192.4949 313.4867 cm 0 0 m -68.569 0 l S Q q 1 0 0 1 123.6757 353.1717 cm 0 0 m 0 25.512 l S Q q 1 0 0 1 192.4949 353.1717 cm 0 0 m -68.569 0 l S Q q 1 0 0 1 123.6757 378.6835 cm 0 0 m 0 25.512 l S Q q 1 0 0 1 192.4949 378.6835 cm 0 0 m -68.569 0 l S Q q 1 0 0 1 123.6757 404.1953 cm 0 0 m 0 39.685 l S Q q 1 0 0 1 192.4949 404.1953 cm 0 0 m -68.569 0 l S Q q 1 0 0 1 123.6757 443.8804 cm 0 0 m 0 41.317 l S Q q 1 0 0 1 192.4949 443.8804 cm 0 0 m -68.569 0 l S Q q 1 0 0 1 123.6757 485.1974 cm 0 0 m 0 39.685 l S Q q 1 0 0 1 192.4949 485.1974 cm 0 0 m -68.569 0 l S Q q 1 0 0 1 123.6757 524.8825 cm 0 0 m 0 39.685 l S Q q 1 0 0 1 192.4949 524.8825 cm 0 0 m -68.569 0 l S Q q 1 0 0 1 123.6757 564.5675 cm 0 0 m 0 27.653 l S Q q 1 0 0 1 192.4949 564.5675 cm 0 0 m -68.569 0 l S Q q 1 0 0 1 123.6757 592.2207 cm 0 0 m 0 33.153 l S Q q 1 0 0 1 192.4949 592.2207 cm 0 0 m -68.569 0 l S Q q 1 0 0 1 123.6757 625.3733 cm 0 0 m 0 38.73 l S Q q 1 0 0 1 192.4949 625.3733 cm 0 0 m -68.569 0 l S Q q 1 0 0 1 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120.9372 cm 0 0 m 0 19.843 l S Q q 1 0 0 1 340.1739 120.9372 cm 0 0 m -20.811 0 l S Q q 1 0 0 1 319.1126 140.7797 cm 0 0 m 0 25.512 l S Q q 1 0 0 1 340.1739 140.7797 cm 0 0 m -20.811 0 l S Q q 1 0 0 1 319.1126 166.2915 cm 0 0 m 0 19.843 l S Q q 1 0 0 1 340.1739 166.2915 cm 0 0 m -20.811 0 l S Q q 1 0 0 1 319.1126 186.134 cm 0 0 m 0 25.512 l S Q q 1 0 0 1 340.1739 186.134 cm 0 0 m -20.811 0 l S Q q 1 0 0 1 319.1126 211.6458 cm 0 0 m 0 37.599 l S Q q 1 0 0 1 339.9239 211.6458 cm 0 0 m -20.561 0 l S Q q 1 0 0 1 319.1126 249.2448 cm 0 0 m 0 25.512 l S Q q 1 0 0 1 339.9239 249.2448 cm 0 0 m -20.561 0 l S Q q 1 0 0 1 319.1126 274.7566 cm 0 0 m 0 16.615 l S Q q 1 0 0 1 339.9239 274.7566 cm 0 0 m -20.561 0 l S Q q 1 0 0 1 319.1126 291.3719 cm 0 0 m 0 22.115 l S Q q 1 0 0 1 339.9239 291.3719 cm 0 0 m -20.561 0 l S Q q 1 0 0 1 319.1126 313.4867 cm 0 0 m 0 39.685 l S Q q 1 0 0 1 339.9239 313.4867 cm 0 0 m -20.561 0 l S Q q 1 0 0 1 319.1126 353.1717 cm 0 0 m 0 25.512 l S Q q 1 0 0 1 339.9239 353.1717 cm 0 0 m -20.561 0 l S Q q 1 0 0 1 319.1126 378.6835 cm 0 0 m 0 25.512 l S Q q 1 0 0 1 339.9239 378.6835 cm 0 0 m -20.561 0 l S Q q 1 0 0 1 319.1126 404.1953 cm 0 0 m 0 39.685 l S Q q 1 0 0 1 339.9239 404.1953 cm 0 0 m -20.561 0 l S Q q 1 0 0 1 319.1126 443.8804 cm 0 0 m 0 41.317 l S Q q 1 0 0 1 339.9239 443.8804 cm 0 0 m -20.561 0 l S Q q 1 0 0 1 319.1126 485.1974 cm 0 0 m 0 39.685 l S Q q 1 0 0 1 339.9239 485.1974 cm 0 0 m -20.561 0 l S Q q 1 0 0 1 319.1126 524.8825 cm 0 0 m 0 39.685 l S Q q 1 0 0 1 339.9239 524.8825 cm 0 0 m -20.561 0 l S Q q 1 0 0 1 319.1126 564.5675 cm 0 0 m 0 27.653 l S Q q 1 0 0 1 339.9239 564.5675 cm 0 0 m -20.561 0 l S Q q 1 0 0 1 319.1126 592.2207 cm 0 0 m 0 33.153 l S Q q 1 0 0 1 339.9239 592.2207 cm 0 0 m -20.561 0 l S Q q 1 0 0 1 319.1126 625.3733 cm 0 0 m 0 38.73 l S Q q 1 0 0 1 339.9239 625.3733 cm 0 0 m -20.561 0 l S Q q 1 0 0 1 319.1126 664.1034 cm 0 0 m 0 27.614 l S Q q 1 0 0 1 339.9239 664.1034 cm 0 0 m -20.561 0 l S Q q 1 0 0 1 319.1126 691.7175 cm 0 0 m 0 44.948 l S Q q 1 0 0 1 339.9239 691.7175 cm 0 0 m -20.561 0 l S Q q 1 0 0 1 339.9239 736.415 cm 0 0 m -20.561 0 l S Q q 1 0 0 1 360.9852 79.6201 cm 0 0 m -20.811 0 l S Q q 1 0 0 1 360.9852 120.9372 cm 0 0 m -20.811 0 l S Q q 1 0 0 1 360.9852 140.7797 cm 0 0 m -20.811 0 l S Q q 1 0 0 1 360.9852 166.2915 cm 0 0 m -20.811 0 l S Q q 1 0 0 1 360.9852 186.134 cm 0 0 m -20.811 0 l S Q q 1 0 0 1 340.1739 211.3958 cm 0 0 m 0 38.099 l S Q q 1 0 0 1 360.9852 211.6458 cm 0 0 m -20.561 0 l S Q q 1 0 0 1 360.9852 249.2448 cm 0 0 m -20.561 0 l S Q q 1 0 0 1 340.1739 274.5066 cm 0 0 m 0 16.865 l S Q q 1 0 0 1 360.9852 274.7566 cm 0 0 m -20.561 0 l S Q q 1 0 0 1 340.1739 291.3719 cm 0 0 m 0 22.115 l S Q q 1 0 0 1 360.9852 291.3719 cm 0 0 m -20.561 0 l S Q q 1 0 0 1 340.1739 313.4867 cm 0 0 m 0 39.685 l S Q q 1 0 0 1 360.9852 313.4867 cm 0 0 m -20.561 0 l S Q q 1 0 0 1 340.1739 353.1717 cm 0 0 m 0 25.512 l S Q q 1 0 0 1 360.9852 353.1717 cm 0 0 m -20.561 0 l S Q q 1 0 0 1 340.1739 378.6835 cm 0 0 m 0 25.512 l S Q q 1 0 0 1 360.9852 378.6835 cm 0 0 m -20.561 0 l S Q q 1 0 0 1 340.1739 404.1953 cm 0 0 m 0 39.685 l S Q q 1 0 0 1 360.9852 404.1953 cm 0 0 m -20.561 0 l S Q q 1 0 0 1 340.1739 443.8804 cm 0 0 m 0 41.317 l S Q q 1 0 0 1 360.9852 443.8804 cm 0 0 m -20.561 0 l S Q q 1 0 0 1 340.1739 485.1974 cm 0 0 m 0 39.685 l S Q q 1 0 0 1 360.9852 485.1974 cm 0 0 m -20.561 0 l S Q q 1 0 0 1 340.1739 524.8825 cm 0 0 m 0 39.685 l S Q q 1 0 0 1 360.9852 524.8825 cm 0 0 m -20.561 0 l S Q q 1 0 0 1 340.1739 564.5675 cm 0 0 m 0 27.653 l S Q q 1 0 0 1 360.9852 564.5675 cm 0 0 m -20.561 0 l S Q q 1 0 0 1 340.1739 592.2207 cm 0 0 m 0 33.153 l S Q q 1 0 0 1 360.9852 592.2207 cm 0 0 m -20.561 0 l S Q q 1 0 0 1 340.1739 625.3733 cm 0 0 m 0 38.73 l S Q q 1 0 0 1 360.9852 625.3733 cm 0 0 m -20.561 0 l S Q q 1 0 0 1 340.1739 664.1034 cm 0 0 m 0 27.614 l S Q q 1 0 0 1 360.9852 664.1034 cm 0 0 m -20.561 0 l S Q q 1 0 0 1 340.1739 691.7175 cm 0 0 m 0 44.948 l S Q q 1 0 0 1 360.9852 691.7175 cm 0 0 m -20.561 0 l S Q q 1 0 0 1 360.9852 736.415 cm 0 0 m -20.561 0 l S Q q 1 0 0 1 361.2352 79.3701 cm 0 0 m 0 41.567 l S Q q 1 0 0 1 361.2352 120.9372 cm 0 0 m 0 19.843 l S Q q 1 0 0 1 361.2352 140.7797 cm 0 0 m 0 25.512 l S Q q 1 0 0 1 361.2352 166.2915 cm 0 0 m 0 19.843 l S Q q 1 0 0 1 361.2352 186.134 cm 0 0 m 0 25.512 l S Q q 1 0 0 1 361.2352 211.6458 cm 0 0 m 0 37.599 l S Q q 1 0 0 1 361.2352 249.2448 cm 0 0 m 0 25.512 l S Q q 1 0 0 1 361.2352 274.7566 cm 0 0 m 0 16.615 l S Q q 1 0 0 1 361.2352 291.3719 cm 0 0 m 0 22.115 l S Q q 1 0 0 1 361.2352 313.4867 cm 0 0 m 0 39.685 l S Q q 1 0 0 1 361.2352 353.1717 cm 0 0 m 0 25.512 l S Q q 1 0 0 1 361.2352 378.6835 cm 0 0 m 0 25.512 l S Q q 1 0 0 1 361.2352 404.1953 cm 0 0 m 0 39.685 l S Q q 1 0 0 1 361.2352 443.8804 cm 0 0 m 0 41.317 l S Q q 1 0 0 1 361.2352 485.1974 cm 0 0 m 0 39.685 l S Q q 1 0 0 1 361.2352 524.8825 cm 0 0 m 0 39.685 l S Q q 1 0 0 1 361.2352 564.5675 cm 0 0 m 0 27.653 l S Q q 1 0 0 1 361.2352 592.2207 cm 0 0 m 0 33.153 l S Q q 1 0 0 1 361.2352 625.3733 cm 0 0 m 0 38.73 l S Q q 1 0 0 1 361.2352 664.1034 cm 0 0 m 0 27.614 l S Q q 1 0 0 1 361.2352 691.7175 cm 0 0 m 0 44.948 l S Q BT /GS1 gs /T1_0 1 Tf 0 6.48 -8 0 132.3103 82.4548 Tm (\032\003\002\006)Tj 6.706 0 Td (\027\002\240)Tj 2.797 0 Td (\255\003\006\004\b\004)Tj 4.208 0 Td (\020\t\212)Tj 3.23 0 Td (\255\006\002\220 )Tj 0.334 -1.2 Td (\b\004)Tj 0 6.48 -8 0 141.9103 200.9927 Tm (-)Tj 0 6.48 -8 0 151.5103 191.9435 Tm (\206\f\211-)Tj -0.247 -1.2 Td (\240\r\b\t\235 )Tj 0.061 -1.2 Td (\(\240\b\t\))Tj 3.982 4.8 Td (\215\r\003\002\240 \f\r)Tj 0 6.48 -8 0 132.3103 241.9569 Tm (-)Tj 0 6.48 -8 0 141.9103 222.0668 Tm (\201\r\b\t\235)Tj 4.72 1.2 Td (\017\206\227\r\r )Tj 0.179 -1.2 Td (\201\t\217\f\002 )Tj 0.027 -1.2 Td (\212\004\204\t-)Tj -0.002 -1.2 Td (\r\b\003\002)Tj 4.169 3.6 Td (N)Tj 2.333 0 Td (\215/\207)Tj 4.045 0 Td (\026\002\213\006\004\217\003 )Tj -0.872 -1.2 Td (\(\f\r\003\), mean )Tj 1.585 -1.2 Td (\(SD\))Tj 4.61 2.4 Td (\017\206\234\r\214 )Tj 0.267 -1.2 Td (\006\004\b\013 )Tj 0.236 -1.2 Td (\b\004)Tj /Span<>> BDC ( )Tj EMC (0 )Tj -0.132 -1.2 Td (\240\r\b\001 )Tj -0.247 -1.2 Td (\(\217\214)Tj 0 3.7778 -4.664 0 168.0464 367.3431 Tm (3)Tj 0 6.48 -8 0 170.7104 369.4435 Tm (\), )Tj -1.69 -1.2 Td (mean )Tj 0.161 -1.2 Td (\(SD\))Tj 3.517 7.2 Td (\017\206\234\r\214 )Tj 0.267 -1.2 Td (\006\004\b\013 )Tj 0.236 -1.2 Td (\b\004)Tj /Span<>> BDC ( )Tj EMC (5 )Tj -0.132 -1.2 Td (\240\r\b\001 )Tj -0.247 -1.2 Td (\(\217\214)Tj 0 3.7778 -4.664 0 168.0464 392.8549 Tm (3)Tj 0 6.48 -8 0 170.7104 394.9554 Tm (\), )Tj -1.69 -1.2 Td (mean )Tj 0.161 -1.2 Td (\(SD\))Tj 4.61 7.2 Td (\017\206\234\r\214 )Tj 0.267 -1.2 Td (\006\004\b\013 )Tj -1.194 -1.2 Td (\b\004)Tj /Span<>> BDC ( )Tj EMC (10 \240\r\b\001 )Tj -0.095 -1.2 Td (\(\217\214)Tj 0 3.7778 -4.664 0 158.4464 418.0208 Tm (3)Tj 0 6.48 -8 0 161.1104 420.1213 Tm (\),mean )Tj -0.382 -1.2 Td (\(SD\))Tj 4.573 4.8 Td (\017\206\234\r\214 \006\004\b\013 )Tj 0.33 -1.2 Td (\b\004)Tj /Span<>> BDC ( )Tj EMC (15 \240\r\b\001 )Tj -0.095 -1.2 Td (\(\217\214)Tj 0 3.7778 -4.664 0 148.8464 458.5219 Tm (3)Tj 0 6.48 -8 0 151.5104 460.6224 Tm (\),mean )Tj -0.382 -1.2 Td (\(SD\))Tj 5.83 3.6 Td (\017\206\234\r\214 )Tj 0.267 -1.2 Td (\006\004\b\013 )Tj -1.194 -1.2 Td (\b\004)Tj /Span<>> BDC ( )Tj EMC (20 \240\r\b\001 )Tj -0.095 -1.2 Td (\(\217\214)Tj 0 3.7778 -4.664 0 158.4465 499.023 Tm (3)Tj 0 6.48 -8 0 161.1105 501.1235 Tm (\),mean )Tj -0.382 -1.2 Td (\(SD\))Tj 5.704 4.8 Td (\017\206\234\r\214 )Tj 0.266 -1.2 Td (\006\004\b\013 )Tj -1.194 -1.2 Td (\b\004)Tj /Span<>> BDC ( )Tj EMC (25 \240\r\b\001 )Tj -0.095 -1.2 Td (\(\217\214)Tj 0 3.7778 -4.664 0 158.4465 538.708 Tm (3)Tj 0 6.48 -8 0 161.1105 540.8085 Tm (\),mean )Tj -0.382 -1.2 Td (\(SD\))Tj 4.775 4.8 Td (\017\206\234\r\214 )Tj 0.266 -1.2 Td (\006\004\b\013 )Tj -0.042 -1.2 Td (\b\004)Tj /Span<>> BDC ( )Tj EMC (30 )Tj 0.146 -1.2 Td (\240\r\b\001 )Tj -0.247 -1.2 Td (\(\217\214)Tj 0 3.7778 -4.664 0 168.0465 579.8096 Tm (3)Tj 0 6.48 -8 0 170.7105 581.91 Tm (\), )Tj -1.69 -1.2 Td (mean )Tj 0.161 -1.2 Td (\(SD\))Tj 3.572 7.2 Td (\017\217\f\002\202\b\r)Tj 0 6.48 -8 0 132.3105 620.0494 Tm (-)Tj 0 6.48 -8 0 141.9105 596.6667 Tm (\b\t\235 \(\t\b)Tj 0 6.48 -8 0 141.9105 618.5298 Tm (-)Tj 0 6.48 -8 0 151.5105 599.9292 Tm (\233\t\204\t)Tj 0 6.48 -8 0 151.5105 615.2673 Tm (-)Tj 0 6.48 -8 0 161.1105 596.9711 Tm (\006\002\004\b\t\r )Tj 0.463 -1.2 Td (\006\004\b\013\))Tj 5.089 4.8 Td (\200\006\002\240\002\f)Tj 0 6.48 -8 0 132.3105 654.1343 Tm (-)Tj 0 6.48 -8 0 141.9106 633.1425 Tm (\202\t\003\r\f\001)Tj 0 6.48 -8 0 141.9106 653.9367 Tm (-)Tj 0 6.48 -8 0 151.5106 629.3 Tm (\b\002\217\003\001 \206\002\f\t )Tj 0.976 -1.2 Td (\(\240\b\t\), )Tj -0.843 -1.2 Td (mean \(SD\))Tj 6.341 4.8 Td (\255\006\002\220 )Tj -0.513 -1.2 Td (\213\004\202\t)Tj 0 6.48 -8 0 141.9106 685.5017 Tm (-)Tj 0 6.48 -8 0 151.5106 669.3796 Tm (\f\r\b\t\235 )Tj -0.09 -1.2 Td (\(\240\b\t\), )Tj 0.259 -1.2 Td (mean )Tj 0.161 -1.2 Td (\(SD\))Tj 4.108 6 Td (\200\006\002\240\002\f\202\t)Tj 0 6.48 -8 0 132.3106 727.5996 Tm (-)Tj 0 6.48 -8 0 141.9106 700.0308 Tm (\003\r\f\001\b\002\217\003\001 )Tj -0.745 -1.2 Td (\003\006\210\240\002\217\212\002\217\002\206)Tj 0 6.48 -8 0 151.5106 730.535 Tm (-)Tj 0 6.48 -8 0 161.1106 696.2369 Tm (\b\002\217\003\t \(\240\b\t\), )Tj 0.501 -1.2 Td (mean \(SD\))Tj /T1_1 1 Tf -95.221 -3.833 Td (Spyridakis)Tj T* (et al. [4])Tj 6.47 1.2 Td (2009)Tj 3.049 0 Td (\206\030\036\006\017\016)Tj 4.103 0 Td (\217\025\236)Tj 3.848 0 Td (30)Tj 3.17 0 Td (\236\f\f\036\004\036\027\017\036 )Tj 1.443 -1.2 Td (\225\025\216)Tj 5.126 1.2 Td (49)Tj 3.251 0 Td (19)Tj 2.517 0 Td (19/0)Tj 5.016 0 Td (\027/\007)Tj 4.913 0 Td (28,5)Tj -0.116 -1.2 Td (\261)Tj /Span<>> BDC ( )Tj EMC (4,5)Tj 4.053 1.2 Td (28,2)Tj -0.117 -1.2 Td (\261)Tj /Span<>> BDC ( )Tj EMC (4,4)Tj 5.147 1.2 Td (27,5)Tj -0.116 -1.2 Td (\261)Tj /Span<>> BDC ( )Tj EMC (2,7)Tj 6.367 1.2 Td (20,8)Tj -0.116 -1.2 Td (\261)Tj /Span<>> BDC ( )Tj EMC (4,1)Tj 6.367 1.2 Td (14,9)Tj -0.116 -1.2 Td (\261)Tj /Span<>> BDC ( )Tj EMC (4,4)Tj 6.241 1.2 Td (10,9)Tj -0.116 -1.2 Td (\261)Tj /Span<>> BDC ( )Tj EMC (2,2)Tj 5.562 1.2 Td (7,1)Tj -0.366 -1.2 Td (\261)Tj /Span<>> BDC ( )Tj EMC (3,1)Tj 4.679 1.2 Td (0/19)Tj 5.794 0 Td (\027/\007)Tj 5.119 0 Td (\027/\007)Tj 5.58 0 Td (\027/\007)Tj -76.108 -2.633 Td (\236\f\f\036\004\036\027\017\036 )Tj 0.186 -1.2 Td (\225\025\216)Tj /Span<>> BDC ( )Tj EMC (+)Tj /Span<>> BDC ( )Tj EMC (PRP)Tj 9.634 1.2 Td (30)Tj 2.517 0 Td (30/0)Tj 5.016 0 Td (\027/\007)Tj 4.913 0 Td (30,9)Tj -0.116 -1.2 Td (\261)Tj /Span<>> BDC ( )Tj EMC (5,1)Tj 4.053 1.2 Td (30,3)Tj -0.117 -1.2 Td (\261)Tj /Span<>> BDC ( )Tj EMC (5,1)Tj 5.49 1.2 Td (25)Tj -0.459 -1.2 Td (\261)Tj /Span<>> BDC ( )Tj EMC (5,8)Tj 6.367 1.2 Td (13,4)Tj -0.116 -1.2 Td (\261)Tj /Span<>> BDC ( )Tj EMC (3,7)Tj 6.617 1.2 Td (7,1)Tj -0.366 -1.2 Td (\261)Tj /Span<>> BDC ( )Tj EMC (3,6)Tj 6.491 1.2 Td (1,5)Tj -0.366 -1.2 Td (\261)Tj /Span<>> BDC ( )Tj EMC (2,1)Tj 5.562 1.2 Td (0,9)Tj -0.366 -1.2 Td (\261)Tj /Span<>> BDC ( )Tj EMC (2,2)Tj 4.679 1.2 Td (0/30)Tj 5.794 0 Td (\027/\007)Tj 5.119 0 Td (\027/\007)Tj 5.58 0 Td (\027/\007)Tj -96.746 -2.633 Td (Mohammadi)Tj T* (et al. [3])Tj 6.47 1.2 Td (2019)Tj 3.449 0 Td (\236\030\026\027)Tj 3.703 0 Td (\217\025\236)Tj 3.848 0 Td (63)Tj 3.17 0 Td (\236\f\f\036\004\036\027\017\036 )Tj 1.443 -1.2 Td (\225\025\216)Tj 4.876 1.2 Td (110)Tj 3.501 0 Td (55)Tj 2.517 0 Td (52/3)Tj 3.572 0 Td (27,5)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (4,81)Tj 6.356 0 Td (41,9)Tj -0.366 -1.2 Td (\261)Tj /Span<>> BDC ( )Tj EMC (8,01)Tj 4.422 1.2 Td (\027/\007)Tj 5.031 0 Td (\027/\007)Tj 6.25 0 Td (\027/\007)Tj 6.25 0 Td (\027/\007)Tj 6.124 0 Td (\027/\007)Tj 5.196 0 Td (\027/\007)Tj 4.445 0 Td (0/55)Tj 5.676 0 Td (23,8)Tj -0.366 -1.2 Td (\261)Tj /Span<>> BDC ( )Tj EMC (4,13)Tj 5.486 1.2 Td (60,9)Tj -0.366 -1.2 Td (\261)Tj /Span<>> BDC ( )Tj EMC (8,26)Tj 5.946 1.2 Td (45,5)Tj -0.366 -1.2 Td (\261)Tj /Span<>> BDC ( )Tj EMC (7,21)Tj -75.624 -1.433 Td (\236\f\f\036\004\036\027\017\036 )Tj 0.186 -1.2 Td (\225\025\216)Tj /Span<>> BDC ( )Tj EMC (+)Tj /Span<>> BDC ( )Tj EMC (PRP)Tj 9.634 1.2 Td (55)Tj 2.517 0 Td (54/1)Tj 3.572 0 Td (29,8)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (7,04)Tj 6.106 0 Td (42,35)Tj -0.366 -1.2 Td (\261)Tj /Span<>> BDC ( )Tj EMC (10,81)Tj 4.672 1.2 Td (\027/\007)Tj 5.031 0 Td (\027/\007)Tj 6.25 0 Td (\027/\007)Tj 6.25 0 Td (\027/\007)Tj 6.124 0 Td (\027/\007)Tj 5.196 0 Td (\027/\007)Tj 4.445 0 Td (0/55)Tj 5.926 0 Td (9,1)Tj -0.616 -1.2 Td (\261)Tj /Span<>> BDC ( )Tj EMC (3,99)Tj 5.486 1.2 Td (33,6)Tj -0.366 -1.2 Td (\261)Tj /Span<>> BDC ( )Tj EMC (6,09)Tj 5.946 1.2 Td (23,1)Tj -0.366 -1.2 Td (\261)Tj /Span<>> BDC ( )Tj EMC (4,48)Tj -96.262 -1.433 Td (Gohar)Tj 0 -1.2 TD (et al. [5])Tj 6.47 1.2 Td (2020)Tj 3.14 0 Td (\213\020\017\023\036\021)Tj 4.011 0 Td (\217\025\236)Tj 3.848 0 Td (50)Tj 3.17 0 Td (\236\f\f\036\004\036\027\017\036 )Tj 1.443 -1.2 Td (\225\025\216)Tj 4.876 1.2 Td (100)Tj 3.501 0 Td (50)Tj 2.517 0 Td (43/7)Tj 3.322 0 Td (26,27)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (4,62)Tj 6.356 0 Td (30,99)Tj -0.116 -1.2 Td (\261)Tj /Span<>> BDC ( )Tj EMC (2,37)Tj 4.053 1.2 Td (29,26)Tj -0.117 -1.2 Td (\261)Tj /Span<>> BDC ( )Tj EMC (1,76)Tj 5.147 1.2 Td (26,46)Tj -0.116 -1.2 Td (\261)Tj /Span<>> BDC ( )Tj EMC (0,97)Tj 6.959 1.2 Td (21)Tj -0.459 -1.2 Td (\261)Tj /Span<>> BDC ( )Tj EMC (1,0)Tj 6.367 1.2 Td (17,5)Tj -0.366 -1.2 Td (\261)Tj /Span<>> BDC ( )Tj EMC (1,25)Tj 6.241 1.2 Td (13,68)Tj -0.116 -1.2 Td (\261)Tj /Span<>> BDC ( )Tj EMC (0,88)Tj 5.562 1.2 Td (10,2)Tj -0.116 -1.2 Td (\261)Tj /Span<>> BDC ( )Tj EMC (0,3)Tj 4.429 1.2 Td (10/50)Tj 5.676 0 Td (16,67)Tj -0.116 -1.2 Td (\261)Tj /Span<>> BDC ( )Tj EMC (1,83)Tj 5.828 1.2 Td (57)Tj -0.459 -1.2 Td (\261)Tj /Span<>> BDC ( )Tj EMC (2,4)Tj 5.446 1.2 Td (24,93)Tj -0.116 -1.2 Td (\261)Tj /Span<>> BDC ( )Tj EMC (1,58)Tj -75.624 -1.433 Td (\236\f\f\036\004\036\027\017\036 )Tj 0.186 -1.2 Td (\225\025\216)Tj /Span<>> BDC ( )Tj EMC (+)Tj /Span<>> BDC ( )Tj EMC (PRP)Tj 9.634 1.2 Td (50)Tj 2.267 0 Td (40/10)Tj 3.572 0 Td (25,07)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (4,83)Tj 6.356 0 Td (30,41)Tj -0.116 -1.2 Td (\261)Tj /Span<>> BDC ( )Tj EMC (3,11)Tj 4.053 1.2 Td (29,17)Tj -0.117 -1.2 Td (\261)Tj /Span<>> BDC ( )Tj EMC (2,46)Tj 5.147 1.2 Td (22,75)Tj -0.116 -1.2 Td (\261)Tj /Span<>> BDC ( )Tj EMC (1,02)Tj 6.367 1.2 Td (16,49)Tj -0.116 -1.2 Td (\261)Tj /Span<>> BDC ( )Tj EMC (1,55)Tj 6.367 1.2 Td (10,93)Tj -0.116 -1.2 Td (\261)Tj /Span<>> BDC ( )Tj EMC (1,26)Tj 6.491 1.2 Td (7,46)Tj -0.366 -1.2 Td (\261)Tj /Span<>> BDC ( )Tj EMC (0,65)Tj 5.562 1.2 Td (4,49)Tj -0.366 -1.2 Td (\261)Tj /Span<>> BDC ( )Tj EMC (0,46)Tj 4.929 1.2 Td (3/50)Tj 5.676 0 Td (10,4)Tj -0.366 -1.2 Td (\261)Tj /Span<>> BDC ( )Tj EMC (2,13)Tj 5.828 1.2 Td (45)Tj -0.459 -1.2 Td (\261)Tj /Span<>> BDC ( )Tj EMC (2,6)Tj 5.446 1.2 Td (16,27)Tj -0.116 -1.2 Td (\261)Tj /Span<>> BDC ( )Tj EMC (2,25)Tj -96.262 -1.433 Td (Boztug)Tj T* (et al. [6])Tj 6.47 1.2 Td (2021)Tj 3.047 0 Td (\230\031\030\006\017\016)Tj 4.105 0 Td (\217\025\236)Tj 3.598 0 Td (183)Tj 3.42 0 Td (\236\f\f\036\004\036\027\017\036 )Tj 1.443 -1.2 Td (\225\025\216)Tj 5.126 1.2 Td (40)Tj 3.251 0 Td (18)Tj 2.517 0 Td (14/4)Tj 3.822 0 Td (26,7)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (5,5)Tj 6.106 0 Td (18,8)Tj -0.116 -1.2 Td (\261)Tj /Span<>> BDC ( )Tj EMC (8,2)Tj 4.172 1.2 Td (\027/\007)Tj 5.031 0 Td (\027/\007)Tj 6.25 0 Td (\027/\007)Tj 6.25 0 Td (\027/\007)Tj 6.124 0 Td (\027/\007)Tj 5.196 0 Td (\027/\007)Tj 4.692 0 Td (\027/\007)Tj 5.546 0 Td (\027/\007)Tj 5.001 0 Td (54,4)Tj -0.366 -1.2 Td (\261)Tj /Span<>> BDC ( )Tj EMC (24,3)Tj 5.946 1.2 Td (16,3)Tj -0.116 -1.2 Td (\261)Tj /Span<>> BDC ( )Tj EMC (5,6)Tj -75.874 -1.433 Td (\236\f\f\036\004\036\027\017\036 )Tj 0.186 -1.2 Td (\225\025\216)Tj /Span<>> BDC ( )Tj EMC (+)Tj /Span<>> BDC ( )Tj EMC (PRP)Tj 9.634 1.2 Td (22)Tj 2.517 0 Td (17/5)Tj 3.822 0 Td (24,7)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (5,5)Tj 6.106 0 Td (22,6)Tj -0.366 -1.2 Td (\261)Tj /Span<>> BDC ( )Tj EMC (11,5)Tj 4.422 1.2 Td (\027/\007)Tj 5.031 0 Td (\027/\007)Tj 6.25 0 Td (\027/\007)Tj 6.25 0 Td (\027/\007)Tj 6.124 0 Td (\027/\007)Tj 5.196 0 Td (\027/\007)Tj 4.692 0 Td (\027/\007)Tj 5.546 0 Td (\027/\007)Tj 5.001 0 Td (37,1)Tj -0.366 -1.2 Td (\261)Tj /Span<>> BDC ( )Tj EMC (16,6)Tj 6.196 1.2 Td (9,0)Tj -0.366 -1.2 Td (\261)Tj /Span<>> BDC ( )Tj EMC (4,5)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\007\003\032)50(\n\n\217\n)-21(\035\030\002)]TJ 53.418 0 Td [(MET)30(A)-41(-)-41.9(ANAL)30(Y)30(SIS)]TJ -53.418 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 2)69(4, \023\0224, 202)23(5)]TJ 43.013 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 2)69(4, \023\0224, 202)23(5)]TJ /T1_4 1 Tf 25 0 0 25 20.8528 56.0378 Tm (142)Tj ET endstream endobj 1465 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\007\016\b)-10(\026\215\025\016 \222\201\021\024\016\215\016\215\021\016 \001\200)-20(\026)11(\025\222\t\001\213\024\220, \025\235\025\202)10(\001\232\016\215\215\025\207 \026\201\025\024\235\025\212\021\026)11(\001\024\021, )]TJ 0 -1 TD [(\017\001\017 \b\222\025\b\025\235 \200\t\200\f\020\016\215\021\004 \201\016\ \213)21.1(\200\t\214)21(\026)11(\001\026)11(\025\r \025\222\016\201\001\026\021\r\215\025\202)10(\025 \t\016\f\016\215\021\004 )]TJ T* [(\201\025\215\021\f\016\b\017)10.1(\025\202)10(\025 \r\025\b\222\001\t\016\215\021\004 \242\222\021\026)11(\016\t\021\001\t\214\215\025\202)10.1(\025 \017)10(\025\222\f\021\017)10(\025\r\025\202)10(\025 \025\211\001 )]TJ T* [(\(\b\021\b)-10(\026)11(\016\024\001\026\021\f\016\b\017\021\207 \025\235\213\025\201 \t\021\026\ )11(\016\201\001\026)-20(\200\201\220 \021\022\024\016\026)11(\001\001\215\001\t\021\213\))]TJ 41.398 3 Td (A platelet rich plasma for pilonidal sinus disease )Tj 4.085 -1 Td [(\(s)10(y)10(stematic r)31(e)11(vie)11(w and meta-analy)10(sis\))]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0.282 Tw 10 0 0 10 42.5197 724.8299 Tm [(5.4.1 for Ma)-17(cOS \(Co)-16(chr)-32.9(ane coll)-16(abor)-33(a)15(t)-32(ion sof)-28(t)-32(w)-12(ar)-24(e\). )]TJ 0.615 Tw 0 -1.218 TD (\025\024\035\017\004\036\f\021\r\036\027\027\t\036 \007\026\027\027\t\036\ \024\023\017\f\t\r\026\035\017 \f)Tj /Span<>> BDC ( )Tj EMC (\023\024\n\024\013\034\033 )Tj 0.683 Tw T* (\f\030\036\007\027\036\020\024 \027\026\004\036\027\017\016 \017)Tj /Span<>> BDC ( )Tj EMC (\f\021\026\027\007\026\030\021\027\t\b \024\021\022\035\024\027\036\027\017\ \005. )Tj -0.042 Tw T* (\203\036\024\002\b\024\007\017\n\024 \024\021\n\036\021\017\021\034, \004\ \021\024 \r)Tj /Span<>> BDC ( )Tj EMC (\023\031\002\035\017\022\026\006\017\016\b \017\f\023\024\035\034\024\r\ \026)Tj 0 Tw (-)Tj -0.009 Tw T* [(\027\t \030\026\027\024\030\024\007\027\t\036 \n\036\021\024\007\t \017\ \f\004\017\f\035\036\027\017\016 )0.5(\023\030\036\007\f\021\026\r\035\036\027\027\t\b )]TJ -0.016 Tw T* (\023\024\022\026\026\021\036\035\036\005 \(\007\027\017, \027\036\007\036\ \035\017\). \212\026\027\027\t\036 \023\030\017\r\036\007\036\027\t \022\ )Tj /Span<>> BDC ( )Tj EMC (\036\007\017)Tj 0 Tw (-)Tj -0.038 Tw 0 -1.218 TD (\027\024\n\031 \027\026\n\036\027\026\021\036\035\033 \n\026\021\036\n\026\ \021\017\004\036\f\022\017\n \023\031\021\036\n. \224\031\n\n\026\030\027\ \024\036 )Tj 0.084 Tw 0 -1.218 TD (\027\026\004\036\027\017\036 \007\017\b\024\021\024\n\017\004\036\f\022\ \017\b \007\026\027\027\t\b \024\023\017\f\t\r\026\035\017 \r)Tj /Span<>> BDC ( )Tj EMC (\r\017\007\036 )Tj 0.198 Tw T* (\024\021\027\024\001\036\027\017\016 \001\026\027\f\024\r \(\210\221\) \f\ )Tj /Span<>> BDC ( )Tj EMC (\031\022\026\026\027\017\036\n 95% \007\024\r\036\030\017)Tj 0 Tw (-)Tj 0.13 Tw T* (\021\036\035\034\027\024\020\024 \017\027\021\036\030\r\026\035\026 \(\212\ \236\), \026)Tj /Span<>> BDC ( )Tj EMC (\027\036\023\030\036\030\t\r\027\t\036)Tj /Span<>> BDC ( )Tj EMC (\227 \r)Tj /Span<>> BDC ( )Tj EMC (\r\017\007\036 )Tj 0.191 Tw T* (\030\026\027\017\006\t \f\030\036\007\027\017\b \f)Tj /Span<>> BDC ( )Tj EMC (95% \212\236. \215\030\017)Tj /Span<>> BDC ( )Tj EMC /T1_2 1 Tf 0 Tw (\033)Tj /T1_1 1 Tf 0.191 Tw /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (0,05 \030\026\027\017\006\031 )Tj 0.146 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\f\030\026\r\027\017\r\026\036\n\t\b \023\024\022\026\026\021\036\035\016\ \b \f\004\017\021\026\035\017 \f\021\026\021\017\f\021\017\004\036\f\022\ \017 )Tj 0.085 Tw 0 -1.218 TD [(\027\026\004\017\n\024\005. )0.6(\003\027\026\004\036\027\017\036 )0.6(I)]TJ 0 Tw 5.83 0 0 5.83 133.9878 582.0239 Tm (2 )Tj 0.085 Tw 10 0 0 10 138.7537 578.6938 Tm [(\002\024\035\036\036 )0.6(50% )0.5(\017\027\021\036\030\023\030\036\021\017\030\024\r\026\035\017 )]TJ 0.303 Tw -9.623 -1.218 Td (\022\026\022 \r\t\f\024\022\017\005 \031\030\024\r\036\027\034 \020\036\021\ \036\030\024\020\036\027\027\024\f\021\017. \204\t \017\f\023\024\035\034\ )Tj 0 Tw (-)Tj 0.258 Tw 0 -1.218 TD [(\024\r\026\035\017 )0.5(\n\024\007\036\035\017 \f\024 \f\035\031\004\026\005\027\t\n )0.5(\220\235\235\036\022\021\024\n )0.5(\r\027\036 \026\r\017)]TJ 0 Tw (-)Tj 0.13 Tw 0 -1.218 TD (\f\017\n\024\f\021\017 \024\021 \031\030\024\r\027\016 \020\036\021\036\030\ \024\020\036\027\027\024\f\021\017, \026)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\032\036 \f\021\030\024\017\035\017 )Tj 0.273 Tw 0 -1.218 TD (\035\036\f\024\r\017\007\027\t\036 \020\030\026\235\017\022\017 \007\035\ \016 \027\026\020\035\016\007\027\024\005 \007\036\n\024\027\f\021\030\026\ \006\017\017 )Tj 0 Tw 0 -1.218 TD (\023\024\035\031\004\036\027\027\t\b \030\036\031\035\034\021\026\021\024\ \r.)Tj /T1_3 1 Tf 0 -2.436 TD (\022\r\213\210\f\001\003\004\003\013 \212\002\t\217\220\004)Tj /T1_1 1 Tf 0.018 Tw 0 -1.218 TD (\200 \024\002\013\036\005 \f\035\024\032\027\024\f\021\017 \002\t\035\024\ \027\026\005\007\036\027\024 27227 \023\031\002\035\017\022\026\006\017\ \005 )Tj 0.127 Tw T* (\(\217\017\f.)Tj /Span<>> BDC ( )Tj EMC (1\). \215\036\030\r\t\n \220\021\026\023\024\n \002\t\035\017 \017\f\022\ \035\033\004\036\027\t \027\036\023\024\035\027\024)Tj 0 Tw (-)Tj -0.061 Tw T* (\021\036\022\f\021\024\r\t\036 \023\031\002\035\017\022\026\006\017\017,\ \017\f\f\035\036\007\024\r\026\027\017\016 \027\026)Tj /Span<>> BDC ( )Tj EMC (\032\017\r\024\021\027\t\b \017)Tj /Span<>> BDC ( )Tj EMC (\f )Tj -0.022 Tw T* (\031\004\026\f\021\017\036\n \007\036\021\036\005, \024\002\024\030\t \035\ \017\021\036\030\026\021\031\030\t. \215\030\017)Tj /Span<>> BDC ( )Tj EMC (\007\026\035\034\027\036\005\001\036\n )Tj 0.024 Tw T* (\f\022\030\017\027\017\027\020\036 \017\f\022\035\033\004\036\027\t \017\ \f\f\035\036\007\024\r\026\027\017\016, \027\036 \f\024\024\021\r\036\021\ \f\021\r\031)Tj 0 Tw (-)Tj 0.07 Tw T* (\033\013\017\036 \022\030\017\021\036\030\017\016\n \r\022\035\033\004\036\ \027\017\016)Tj /Span<>> BDC ( )Tj EMC (\227 831, \n\036\021\026\026\027\026\035\017\t)Tj /Span<>> BDC ( )Tj EMC (\227 )Tj 0.285 Tw T* (55. \224\030\036\007\017 \024\021\024\002\030\026\027\027\t\b \030\026\027\ \007\024\n\017\017\030\024\r\026\027\027\t\b \022\035\017\027\017)Tj 0 Tw (-)Tj 0.062 Tw T* [(\004\036\f\022\017\b )0.5(\017\f\f\035\036\007\024\r\026\027\017\005 2 )0.5(\002\t\035\017 \017\f\022\035\033\004\036\027\t )0.5(\023\024)]TJ /Span<>> BDC ( )Tj EMC (\023\030\017\004\017\027\036 )Tj 0.055 Tw T* (\023\030\017\n\036\027\036\027\017\016 PRP \r)Tj /Span<>> BDC ( )Tj EMC (\f\024\004\036\021\026\027\017\017 \f)Tj /Span<>> BDC ( )Tj EMC (\017\f\f\036\004\036\027\017\036\n \225\025\216 \f)Tj /Span<>> BDC ( )Tj EMC (\024\021)Tj 0 Tw (-)Tj 0.104 Tw T* (\022\030\t\021\t\n \f\023\024\f\024\002\024\n \r\036\007\036\027\017\016\ \030\026\027\t \007\035\016 \035\036\004\036\027\017\016 \024\f\021\030\ \024)Tj 0 Tw (-)Tj 0.066 Tw T* (\020\024 \r\024\f\023\026\035\036\027\017\016 \225\025\216 \r)Tj /Span<>> BDC ( )Tj EMC (\f\021\026\006\017\017 \026\002\f\006\036\007\017\030\024\r\026\027\017\016\ [9\22610], )Tj 0.165 Tw T* [(\036\013\036 \024\007\027\024 )0.5(\017\f\022\035\033\004\036\027\024 \023\024)]TJ /Span<>> BDC ( )Tj EMC 10.722 0 Td [(\023\030\017\004\017\027\036 )0.5(\027\036\023\024\035\027\024\020\024 \024\023\017\f\026)]TJ 0 Tw (-)Tj 0.357 Tw -10.722 -1.218 Td (\027\017\016 \007\026\027\027\t\b \017)Tj /Span<>> BDC ( )Tj EMC (\017\n\036\033\013\036\020\024\f\016 \023\030\024\007\024\035\032\036\027\ \017\016 \007\026\027\027\024\020\024 )Tj 0.184 Tw 23.244 38.97 Td [(\017\f\f\035\036\007\024\r\026\027\017\016 )0.5(\(\235\026\026 )0.5(III\) [11]. \215\030\017)]TJ /Span<>> BDC ( )Tj EMC 15.388 0 Td [(\023\030\024\r\036\007\036\027\017\017 )0.5(\023\024)]TJ 0 Tw (-)Tj 0.362 Tw -15.388 -1.218 Td (\017\f\022\026 \r)Tj /Span<>> BDC ( )Tj EMC (\002\017\002\035\017\024\020\030\026\235\017\004\036\f\022\017\b \007\026\ \027\027\t\b \017\f\f\035\036\007\024\r\026\027\017\005, )Tj -0.03 Tw T* (\r\022\035\033\004\036\027\027\t\b \r)Tj /Span<>> BDC ( )Tj EMC (\n\036\021\026\026\027\026\035\017, \027\036 \002\t\035\024 \027\026\005\ \007\036\027\024 \007\024\023\024\035\027\017)Tj 0 Tw (-)Tj 0 -1.218 TD (\021\036\035\034\027\t\b \f\021\026\021\036\005.)Tj -0.045 Tw 0 -1.218 TD (\230\026\022\017\n \024\002\030\026\024\n, \r)Tj /Span<>> BDC ( )Tj EMC (\n\036\021\026\026\027\026\035\017 \002\t\035\024 \r\022\035\033\004\036\ \027\024 4 \030\026\027\007\024)Tj 0 Tw (-)Tj 0.104 Tw 0 -1.218 TD [(\n\017\017\030\024\r\026\027\027\t\b )0.5(\022\035\017\027\017\004\036\f\022\017\b \017\f\f\035\036\007\024\r\026\027\ \017\016 )0.5([3\2266]. \236\b )]TJ 0 Tw T* (\b\026\030\026\022\021\036\030\017\f\021\017\022\026 \023\030\036\007\f\021\ \026\r\035\036\027\026 \r)Tj /Span<>> BDC ( )Tj EMC (\021\026\002\035. 1.)Tj /T1_3 1 Tf 0.458 Tw 0 -2.436 TD (\225\004\006\004\220\003\r\006\t\217\003\t\220\004 \222\021\225 \210)Tj /Span<>> BDC ( )Tj EMC (\212\004\204\t\r\b\003\002, \220\f\211\201\r\b\b\013\216 )Tj 0 Tw 0 -1.218 TD ()Tj /Span<>> BDC ( )Tj EMC (\t\217\217\f\r\240\002\004\b\t\235)Tj /T1_1 1 Tf -0.031 Tw 0 -1.218 TD (\200\024 \r\f\036 \017\f\f\035\036\007\024\r\026\027\017\016 [3\2266] \002\ \t\035\017 \r\022\035\033\004\036\027\t \023\026\006\017\036\027\021\t, \ )Tj 0.04 Tw 0 -1.218 TD (\031)Tj /Span<>> BDC ( )Tj EMC (\022\024\021\024\030\t\b, \023\024)Tj /Span<>> BDC ( )Tj EMC (\007\026\027\027\t\n \024\f\n\024\021\030\026, \002\t\035 \031\f\021\026\ \027\024\r\035\036\027 \007\017\026\020)Tj 0 Tw (-)Tj -0.002 Tw T* (\027\024: \b\030\024\027\017\004\036\f\022\024\036 \r\024\f\023\026\035\ \036\027\017\036 \220\023\017\021\036\035\017\026\035\034\027\024\020\024\ \022\024\023\004\017)Tj 0 Tw (-)Tj T* (\022\024\r\024\020\024 \b\024\007\026.)Tj 0.055 Tw T* (\203\036\024\002\b\024\007\017\n\024 \024\021\n\036\021\017\021\034, \004\ \021\024, \r)Tj /Span<>> BDC ( )Tj EMC (\024\021\035\017\004\017\036 \024\021 \007\030\031\020\017\b \026\r\021\024\ )Tj 0 Tw (-)Tj -0.005 Tw 0 -1.218 TD (\030\024\r, Gohar \204.\204. \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. [5] \021\026\022\032\036 \026\027\026\035\017\017\030\ \024\r\026\035\017 \030\036)Tj 0 Tw (-)Tj 0 -1.218 TD (\031\035\034\021\026\021\t \035\036\004\036\027\017\016 \023\026\006\017\ \036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\030\036\006\017\007\017\r\024\n \225\025\216.)Tj 0.125 Tw 0 -1.218 TD (\200 \023\031\002\035\017\022\026\006\017\017 Boztug C.Y. \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. [6] \017\f\f\035\036\007\024\r\026\021\036)Tj 0 Tw (-)Tj 0.044 Tw 0 -1.218 TD (\035\017 \r\022\035\033\004\026\035\017 \027\036 \021\024\035\034\022\024\ \020\030\031\023\023\t \n\036\f\021\027\024\020\024 \023\030\017\n\036\027\ \036\027\017\016 )Tj -0.005 Tw 0 -1.218 TD [(PRP )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC [(\f\024\004\036\021\026\027\017\017 )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC [(\017\f\f\036\004\036\027\017\036\n )0.5(\225\025\216 )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC [(\024\021\022\030\t\021\t\n )0.5(\f\023\024\f\024)]TJ 0 Tw (-)Tj 0.09 Tw 0 -1.218 TD (\002\024\n \r\036\007\036\027\017\016 \030\026\027\t \017)Tj /Span<>> BDC ( )Tj EMC (\017\024\035\017\030\024\r\026\027\027\024\020\024 \017\f\f\036\004\036\ \027\017\016 \225\025\216 )Tj -0.007 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\024\021\022\030\t\021\t\n \f\023\024\f\024\002\024\n \r\036\007\036\027\ \017\016 \030\026\027\t \007\035\016 \035\036\004\036\027\017\016 \b\030\ \024)Tj 0 Tw (-)Tj -0.046 Tw T* [(\027\017\004\036\f\022\024\020\024 \r\024\f\023\026\035\036\027\017\016 \ )0.5(\225\025\216, )0.5(\027\024 \017)]TJ /Span<>> BDC ( )Tj EMC [(\020\030\031\023\023\031 )0.5(\n\017\027\017\n\026\035\034\027\024\020\024 )]TJ 0.094 Tw T* [(\017\027\r\026\017\r\027\024\020\024 )0.6(\r\n\036\001\026\021\036\035\034\f\021\r\026 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 12.88 0 Td [(\024\002\255\036\n\036 )0.5(\022\033\030\036\021\026\032\026 )0.6(\225\025\216 )]TJ -0.04 Tw -12.88 -1.218 Td (\f)Tj /Span<>> BDC ( )Tj EMC (\n\036\f\021\027\t\n \023\030\017\n\036\027\036\027\017\036\n PRP. \212\026\ \027\027\026\016 \022\024\020\024\030\021\026 \023\026\006\017\036\027)Tj 0 Tw (-)Tj 0.059 Tw T* (\021\024\r \f\024\024\021\r\036\021\f\021\r\024\r\026\035\026 \022\030\017\ \021\036\030\017\016\n \017\f\022\035\033\004\036\027\017\016 \017, \021\ \026\022\017\n )Tj 0 Tw T* (\024\002\030\026\024\n, \027\036 \002\t\035\026 \023\030\024\026\027\026\ \035\017\017\030\024\r\026\027\026.)Tj /T1_3 1 Tf 3.08 Tw 0 -2.436 TD (\215\r\003\002\240\t\220\004 \212\006\002\r\240\r\b\t\235 \002\212\r\006\ \004\003\t\b\002\n\002 )Tj 0 Tw 0 -1.218 TD (\214\r\232\004\003\r\f\001\217\003\004)Tj /T1_1 1 Tf 0.18 Tw T* (\200 \022\026\004\036\f\021\r\036 \023\036\030\017\024\023\036\030\026\006\ \017\024\027\027\024\005 \023\030\024\235\017\035\026\022\021\017\022\017\ \023\026\006\017)Tj 0 Tw (-)Tj 0.213 Tw T* (\036\027\021\026\n, \r\022\035\033\004\036\027\027\t\n \r)Tj /Span<>> BDC ( )Tj EMC (\017\f\f\035\036\007\024\r\026\027\017\016 [3\2265], \r\r\036\007\036\027\ \026 )Tj 0.208 Tw T* [(1 \007\024\026 \026\027\021\017\002\026\022\021\036\030\017\026\035\034\ \027\024\020\024 )0.5(\023\030\036\023\026\030\026\021\026 \r\027\031\021\030\017\r\036\027\027\ \024 )]TJ 0.512 Tw T* (\007\024)Tj /Span<>> BDC ( )Tj EMC (\024\023\036\030\026\021\017\r\027\024\020\024 \r\n\036\001\026\021\036\035\ \034\f\021\r\026 \(\006\036\235\026\035\024\f\023\024\030\017\027\t )Tj 0.303 Tw T* ([3,5] \017\035\017 \023\036\027\017\006\017\035\035\017\027 \001\017\030\ \024\022\024\020\024 \f\023\036\022\021\030\026 \007\036\005\f\021\r\017\ \016 )Tj 0.196 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\017\027\020\017\002\017\021\024\030\024\n \002\036\021\026-\035\026\022\ \021\026\n\026 [4]\). \200)Tj /Span<>> BDC ( )Tj EMC (\017\f\f\035\036\007\024\r\026\027\017\017 )Tj 0.106 Tw T* (Boztug C.Y. \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. [6] \007\026\027\027\t\b \024)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\r\036\007\036\027\017\017 \026\027\021\017)Tj 0 Tw (-)Tj T* (\002\017\024\021\017\022\024\023\030\024\235\017\035\026\022\021\017\022\ \017 \027\036\021.)Tj 0.012 Tc -0.046 Tw T* (\200 \023\024\035\024\032\036\027\017\017 \035\036\032\026 \027\026)Tj /Span<>> BDC ( )Tj EMC (\032\017\r\024\021\036 \023\024\007 \n\036\f\021\027\024\005 [3,4], \f\023\ \017)Tj 0 Tc 0 Tw (-)Tj 0.012 Tc 0.153 Tw T* (\027\026\035\034\027\024\005 [5] \017\035\017 \024\002\013\036\005 [6] \026\ \027\036\f\021\036\017\036\005 \023\024\f\035\036 \030\026)Tj 0 Tc 0 Tw (-)Tj 0.012 Tc 0.114 Tw T* (\r\036\007\036\027\017\016 \016\020\024\007\017\006 \023\035\026\f\021\t\ \030\036\n, \031\007\026\035\036\027\017\016 \r\024\035\024\f \r)Tj /Span<>> BDC ( )Tj EMC [(\024\027\036)11.9( )]TJ 0.257 Tw T* (\023\035\026\027\017\030\031\036\n\024\020\024 \r\n\036\001\026\021\036\035\ \034\f\021\r\026 \017)Tj /Span<>> BDC ( )Tj EMC (\024\002\030\026\002\024\021\022\017 \024\023\036\030\026)Tj 0 Tc 0 Tw (-)Tj 0.012 Tc 0.182 Tw T* (\006\017\024\027\027\024\020\024 \023\024\035\016 \030\026\f\021\r\024\030\ \024\n \026\027\021\017\f\036\023\021\017\022\026 \r\017\031\026\035\017\ \017)Tj 0 Tc 0 Tw (-)Tj 0.012 Tc 0.159 Tw T* [(\030\024\r\026\027\t \024\021\r\036\030\f\021\017\016 \225\025\216, \024\ \023\030\036\007\036\035\036\027\026 \023\030\024\021\016\032\036\027\027\ \024\f\021\034)12( )]TJ 0.12 Tw T* (\f\017\027\031\f\026, \r\t\023\024\035\027\036\027\024 \022\024\027\021\030\ \026\f\021\017\030\024\r\026\027\017\036 \b\024\007\026 \030\026\f\021\r\ \024)Tj 0 Tc 0 Tw (-)Tj 0.012 Tc 0.09 Tw T* (\030\024\n \n\036\021\017\035\036\027\024\r\024\005 \f\017\027\017 [4\226\ 5], \023\030\024\017\r\036\007\036\027 \220\035\035\017\023\021\017)Tj 0 Tc 0 Tw (-)Tj 0.012 Tc 0.199 Tw 0 -1.218 TD (\004\036\f\022\017\005 \017\035\017 \030\024\n\002\024\r\017\007\027\t\005\ \030\026\030\036 \022\024\032\017 \017)Tj /Span<>> BDC ( )Tj EMC (\023\024\007\022\024\032)Tj 0 Tc 0 Tw (-)Tj 0.012 Tc 0.018 Tw 0 -1.218 TD [(\027\024-\032\017\030\024\r\024\005 \022\035\036\021\004\026\021\022\017\ , \225\025\216 \017\f\f\036\004\036\027 \036\007\017\027\t\n \002\035\024\ \022\024\n)12( )]TJ 0.047 Tw 0 -1.218 TD (\r)Tj /Span<>> BDC ( )Tj EMC (\023\030\036\007\036\035\026\b \007\024\030\024\r\t\b \021\022\026\027\036\ \005 \007\024)Tj /Span<>> BDC ( )Tj EMC (\235\026\f\006\017\017, \023\024\022\030\t\r\026\033)Tj 0 Tc 0 Tw (-)Tj 0.012 Tc 0.053 Tw 0 -1.218 TD (\013\017\005 \022\030\036\f\021\036\006 \017)Tj /Span<>> BDC ( )Tj EMC (\022\024\023\004\017\022, \r\t\023\024\035\027\036\027 \020\036\n\024\f\021\ \026, \027\026\035\024\032\036)Tj 0 Tc 0 Tw (-)Tj 0.012 Tc -0.042 Tw 0 -1.218 TD [(\027\026 \026\002\f\024\030\002\017\030\031\033\013\026\016 \b\035\024\023\ \004\026\021\024\002\031\n\026\032\027\026\016 \026\f\036\023\021\017\004\ \036\f\022\026\016)12( )]TJ -0.012 Tw 0 -1.218 TD (\023\024\r\016\022\026.)Tj 0 Tc 0.073 Tw 0 -1.218 TD (\200\f\036 \023\026\006\017\036\027\021\t [3\2266] \r\t\023\017\f\026\027\ \t \r)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\r\t\036 \f\031\021\022\017 \023\024\f\035\036 )Tj 0 Tw 0 -1.218 TD (\023\030\024\r\036\007\036\027\017\016 \024\023\036\030\026\021\017\r\027\ \024\020\024 \r\n\036\001\026\021\036\035\034\f\021\r\026.)Tj ET q 42.52 100.97 221.102 208.748 re W n q /GS0 gs 221.1023475 0 0 208.8589076 42.5196833 100.8590891 cm /Im0 Do Q Q BT 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 9 0 0 9 42.5197 90.1701 Tm (\022\t\217\210\b\002\220 1.)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf ( \t\034\022\024\021 \022)Tj /Span<>> BDC ( )Tj EMC (\034\035\025\034\033 \027\022\035\016\033\037\035\023\033\032 \b\027\030\ \006\016\035\037\037\020\037\027\022\031\037)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0 -1.2 TD [(F)-16(igure 1)47.1(.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf ( Search and selection of)Tj /Span<>> BDC ( )Tj EMC (literature for meta-analysis)Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\007\003\032)50(\n\n\217\n)-21(\035\030\002)]TJ 53.418 0 Td [(MET)30(A)-41(-)-41.9(ANAL)30(Y)30(SIS)]TJ /T1_4 1 Tf 25 0 0 25 504.7397 56.0378 Tm (141)Tj ET endstream endobj 1466 0 obj <>stream AdobedC     '$''''$25552;;;;;;;;;;:   u!1"26AQTu$3Uaq#4BDR %&'()*5789:CEFGHIJSVWXYZbcdefghijrstvwxyz?^bz`50-)%)qN!>zy9lWW /rI}SK|u_}T{*+}`U9^$ʩ_A%>UNW /rI}SK|u_}T{*+}`U9^$ʩ_A%>UNW /rI}SK|u_}T{*+}`U9^$ʫ-$Dz#ߌUNW /rI}SK|u_}T{*+}`U9^$ʩ_A%>UNW /rI}SK|u_}T{*+}`U9^$ʩ_A%>UNW /rI}SK|z4ڝr,% *Q;RQ$"dVeC!ԅs3Ͽ}аgr镤j%[9)ЍأVaҰ^BrfqòqDRだAIB4\nr<jVW+Ru%F%b"$dA[K$W6~9"\xioϓXt >VW. ~68O֬I女HJ Y) ,n; 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/Span<>> BDC ( )Tj EMC (\n\036\f\021\027\t\n \023\030\017\n\036\027\036\027\017\036\n PRP [3\226\ 6]. \212\026\027\027\t\005 )Tj 0.257 Tw T* [(\n\036\021\024\007 \007\036\n\024\027\f\021\030\017\030\031\036\021 )0.5(\r\t\f\024\022\031\033 \220\235\235\036\022\021\017\r\027\024\f\021\034 \ \(\026)]TJ 0 Tw (-)Tj 0.049 Tw T* (\032\017\r\035\036\027\017\036\) \017)Tj /Span<>> BDC ( )Tj EMC (\002\036\024\023\026\f\027\024\f\021\034 \(\024\021\f\031\021\f\021\r\017\ \036 \024\f\035\024\032\027\036\027\017\005\), )Tj 0.206 Tw 0 -1.218 TD (\r)Tj /Span<>> BDC ( )Tj EMC (\f\r\016\017 \f)Tj /Span<>> BDC ( )Tj EMC (\004\036\n \023\030\036\007\n\036\021\024\n \f\017\f\021\036\n\026\021\017\ \004\036\f\022\024\020\024 \024\002\024\030\026 )Tj 0.271 Tw 0 -1.218 TD (\017)Tj /Span<>> BDC ( )Tj EMC (\n\036\021\026\026\027\026\035\017\026 \016\r\035\016\036\021\f\016 \024\ \002\024\002\013\036\027\017\036 \f\031\013\036\f\021\r\031\033\013\017\b\ )Tj 0.088 Tw T* (\007\026\027\027\t\b, 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\f\030\026\r\027\017\021\034 \220\235\235\036\022\021\017\r\027\024\ \f\021\034 \(\026)Tj 0 Tw (-)Tj 0.52 Tw T* [(\032\017\r\035\036\027\017\036 \023\024\f\035\036\024\023\036\030\026\006\ \017\024\027\027\024\005 )0.5(\030\026\027\t\) \017)]TJ /Span<>> BDC ( )Tj EMC (\002\036\024\023\026\f)Tj 0 Tw (-)Tj 0.131 Tw T* (\027\024\f\021\034 \(\004\026\f\021\024\021\026 \024\f\035\024\032\027\036\ \027\017\005\) \007\r\031\b \f\023\024\f\024\002\024\r \035\036\004\036\027\ \017\016 )Tj 0.052 Tw T* (\225\025\216)Tj /Span<>> BDC ( )Tj EMC (\227 \f)Tj /Span<>> BDC ( )Tj EMC (\023\030\017\n\036\027\036\027\017\036\n \n\036\021\024\007\017\022\017 \ PRP \017)Tj /Span<>> BDC ( )Tj EMC (\f \017\f\f\036\004\036\027\017\036\n )Tj 0.138 Tw T* (\220\023\017\021\036\035\017\026\035\034\027\024\020\024 \022\024\023\004\ \017\022\024\r\024\020\024 \b\024\007\026 \002\036 \r\r\036\007\036\027\ \017\016 \026\031)Tj 0 Tw (-)Tj 0.243 Tw T* (\021\024\023\035\026\n\t, \024\002\024\020\026\013\036\027\027\024\005 \ \021\030\024\n\002\024\006\017\021\026\n\017, \f)Tj /Span<>> BDC ( )Tj EMC (\024\021\022\030\t\021\t\n )Tj 0 Tw T* (\r\036\007\036\027\017\036\n \030\026\027\t \r)Tj /Span<>> BDC ( )Tj EMC (\024\002\036\017\b \020\030\031\023\023\026\b.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0.01 Tc 0.018 Tw 14 0 0 14 70.936 420.3798 Tm [(\f\026\017\031\034\022\024\232)5( \031)5(\016)-18.3(\240\034)-31(\024)35(\037\226\232)]TJ 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0 Tc 0.436 Tw 10 0 0 10 70.8661 396.0238 Tm (\224\017\f\021\036\n\026\021\017\004\036\f\022\017\005 \024\002\024\030\ \017)Tj /Span<>> BDC ( )Tj EMC (\n\036\021\026\026\027\026\035\017 \r\t\023\024\035\027\036\027\t )Tj 0.416 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\f\024\024\021\r\036\021\f\021\r\017\017 \f)Tj /Span<>> BDC ( )Tj EMC (\n\036\032\007\031\027\026\030\024\007\027\t\n\017 \030\036\022\024\n\036\ \027\007\026\006\017)Tj 0 Tw (-)Tj 0.224 Tw T* [(\016\n\017 PRISMA \(T)47(he p)25(r)-24(efer)-23.9(r)-24(ed r)-23.9(epor)-22(t)-32(ing i)-24(tems for sy)-13(s)]TJ 0 Tw (-)Tj 0.36 Tw T* [(tema)15(t)-32(ic r)-24(ev)-16(iews and me)-12(t)15(a-anal)35(y)-13(ses check l)-31(ist\) [8] )]TJ 0.331 Tw T* (\007\r\031\n\016 \027\036\026\r\017\f\017\n\t\n\017 \017\f\f\035\036\007\ \024\r\026\021\036\035\016\n\017. \215\024\017\f\022 \035\017)Tj 0 Tw (-)Tj 0.227 Tw T* (\021\036\030\026\021\031\030\t \024\f\031\013\036\f\021\r\035\016\035\f\016\ \r)Tj /Span<>> BDC ( )Tj EMC (\220\035\036\022\021\030\024\027\027\t\b \002\026\026\b \007\026\027)Tj 0 Tw (-)Tj 0.305 Tw T* [(\027\t\b El)-30.9(ibr)-33(ar)-24(y, P)20(ubMed \017)]TJ /Span<>> BDC ( )Tj EMC [(Co)-16(chr)-32.9(ane L)-32(ibr)-33(ar)-24(y, \027\036 \017\n\036\035 )]TJ 0.258 Tw T* (\024\020\030\026\027\017\004\036\027\017\005 \023\024)Tj /Span<>> BDC ( )Tj EMC (\007\026\021\036 \023\031\002\035\017\022\026\006\017\017 \017)Tj /Span<>> BDC ( )Tj EMC (\002\t\035 \026\r\036\030\001\036\027 )Tj 0.316 Tw T* (14.05.2025 \020. \215\024\017\f\022\024\r\t\005 \026\023\030\024\f \002\ \t\035 \f\035\036\007\031\033\013\017\n: )Tj 0.127 Tw T* [(\(\(\(\237P)-24(il)30.1(onid)42(al\241[All F)-18.9(ields] A)51(ND \(\237disease\241[MeSH T)40(er)-16(ms] )]TJ 0.204 Tw T* [(OR \237disease\241[All F)-19(ields] OR \237diseases\241[All F)-19(ields] OR )]TJ 0.178 Tw T* [(\237disease s\241[All F)-19(ields] OR \237diseased\241[All F)-19(ields]\)\) OR )]TJ 0.474 Tw T* [(\(\237pil)30(onid)42(al sinus\241[MeSH T)39.9(er)-15.9(ms] OR \(\237P)-23.9(il)30(onid)42(al\241[All )]TJ -0.001 Tw T* [(F)-19(ields] A)51(ND \237sinus\241[All F)-19.1(ields]\) OR \237pil)30(onid)42(al sinus\241[All )]TJ 0.731 Tw T* [(F)-19(ields]\) )0.6(OR )0.5(\(\237pil)30(onid)42(al )0.5(sinus\241[MeSH )0.5(T)40(er)-16(ms] )0.6(OR )]TJ 0.384 Tw T* [(\(\237P)-24(il)30.1(onid)42(al\241[All F)-19(ields] A)51(ND \237sinus\241[All F)-19(ields]\) OR )]TJ 0.09 Tw T* [(\237pil)30(onid)42(al sinus\241[All F)-19(ields] OR \(\237P)-24(il)30.1(onid)41.9(al\241[All F)-19(ields] )]TJ T* [(A)51(ND \237cy)-13(st\241[All F)-19(ields]\) OR \237pil)30(onid)42(al cy)-13(st\241[All F)-19(ields]\) )]TJ 0.249 Tw T* [(OR \237sa)-17(cr)-32(o)-16(co)-16(ccygeal\241[All F)-19(ields]\) A)51(ND \(\237pl)-15.9(a)15(tele)-12(t r)-37(ich )]TJ 0.265 Tw T* [(pl)-16(as)26(ma\241[MeSH T)40(er)-16(ms] OR \(\237pl)-16(a)15(tele)-12(t r)-36.9(ich\241[All F)-19(ields] )]TJ 0.014 Tw T* [(A)51(ND \237pl)-16(as)26(ma\241[All F)-19(ields]\) OR \237pl)-16(a)15.1(tele)-12(t r)-37(ich pl)-16(as)26.1(ma\241[All )]TJ 0.04 Tw T* [(F)-19(ields] OR \(\237pl)-16(a)15(tele)-11.9(t\241[All F)-18.9(ields] A)51(ND \237r)-37(ich\241[All F)-19(ields] )]TJ 0.014 Tw T* [(A)51(ND \237pl)-16(as)26(ma\241[All F)-19(ields]\) OR \237pl)-16(a)15.1(tele)-12(t r)-37(ich pl)-16(as)26.1(ma\241[All )]TJ 0.3 Tw T* [(F)-19(ields]\)\) )0.6(OR )0.5(\(\237phar)-16(ma)-17(col )0.5(r)-24(es )0.5(per)-9.9(spec)-16(t\241[Jour)-14.9(nal] )0.5(OR )]TJ -0.067 Tw T* [(\237p)25(r)-24(p\241[All F)-19(ields]\) OR \(\237pl)-15.9(a)15(tele)-12(t r)-37(ich \251br)-37(in\241[MeSH T)40(er)-16(ms] )]TJ 0.066 Tw T* [(OR \(\237pl)-16(a)15(tele)-11.9(t r)-37(ich\241[All F)-19(ields] )0.5(A)51(ND \237\251br)-37(in\241[All )0.5(F)-19(ields]\) )]TJ 0.151 Tw T* [(OR \237pl)-16(a)15(tele)-11.9(t r)-37(ich \251br)-37(in\241[All )0.5(F)-19(ields] OR \(\237pl)-15.9(a)15(tele)-12(t\241[All )]TJ 0.104 Tw 23.244 64.543 Td [(F)-19(ields] A)51(ND \237r)-37(ich\241[All F)-19(ields] A)51(ND \237\251br)-37(in\241[All F)-19(ields]\) )]TJ 0.039 Tw T* [(OR \237pl)-16(a)15(tele)-12(t r)-37(ich \251br)-37(in\241[All F)-19(ields]\) OR \(\(\237aut)17(ol)30(o)-16(g\241[All )]TJ 0.026 Tw T* [(F)-19(ields] )0.5(OR )0.5(\237aut)17(ol)30.1(o)-16(geous\241[All )0.5(F)-19(ields] )0.6(OR )0.5(\237aut)17(ol)30(o)-16(gic\241[All )]TJ -0.025 Tw T* [(F)-19(ields] )0.5(OR )0.5(\237aut)17(ol)30.1(o)-16(gical\241[All )0.6(F)-19.1(ields] )0.5(OR )0.5(\237aut)17(ol)30(o)-16(gous\241[All )]TJ 0.401 Tw T* [(F)-19(ields] OR \237aut)17(ol)30(o)-16(gousl)35(y\241[All F)-19(ields]\) A)51(ND \(\237bl)30.1(o)-16(od )]TJ 0.284 Tw T* [(pl)-16(a)15(tele)-11.9(ts\241[MeSH )0.5(T)40(er)-16(ms] )0.5(OR )0.5(\(\237bl)30(o)-15.9(od\241[All )0.5(F)-19(ields] )0.5(A)51(ND )]TJ 0.052 Tw 0 -1.218 TD [(\237pl)-16(a)15(tele)-11.9(ts\241[All F)-19(ields]\) OR \237bl)30(o)-16(od pl)-16(a)15(tele)-11.9(ts\241[All F)-19(ields] )]TJ 0.145 Tw 0 -1.218 TD [(OR )0.6(\237pl)-16(a)15(tele)-12(t\241[All )0.7(F)-19(ields] )0.6(OR )0.6(\237pl)-16(a)15(tele)-12(ts\241[All )0.7(F)-19(ields] )0.6(OR )]TJ 0.408 Tw T* [(\237pl)-16(a)15(tele)-11.9(t s\241[All F)-19(ields] OR \237pl)-16(a)15(tele)-11.9(tes\241[All F)-19(ields]\) )]TJ 0.214 Tw T* [(A)51(ND \237r)-37(ich\241[All F)-19(ields] A)51(ND \237gel\241[All F)-18.9(ields]\), \253\023\017\035\024)]TJ 0 Tw (-)Tj 0.128 Tw T* [(\027\017\007\026\035\034\027\026\016 \002\024\035\036\027\034\273, )0.5(\253\023\017\035\024\027\017\007\026\035\034\027\t\005 \f\017\027\031\f\273\ , \253\220\023\017)]TJ 0 Tw (-)Tj 0.287 Tw T* (\021\036\035\017\026\035\034\027\t\005 \022\024\023\004\017\022\024\r\t\005\ \b\024\007\273, \253\026\031\021\024\023\035\026\n\026, \024\002\024\020\ \026)Tj 0 Tw (-)Tj 0.424 Tw T* [(\013\036\027\027\026\016 )0.6(\021\030\024\n\002\024\006\017\021\026\n\017\273, )0.5(\253\026\031\021\024\023\035\026\n\026\020\036\035\034, )0.6(\002\024\020\026\021\t\005 )]TJ 0 Tw T* (\021\030\024\n\002\024\006\017\021\026\n\017\273.)Tj 0.104 Tw T* (\236 \026\023\030\024\f\026 \002\t\035\017 \017\f\022\035\033\004\036\027\ \t \017\f\f\035\036\007\024\r\026\027\017\016 \027\026)Tj /Span<>> BDC ( )Tj EMC (\007\036\021\016\b )Tj 0.148 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\032\017\r\024\021\027\t\b, \016\t\022\024\r\t\036 \024\020\030\026\027\ \017\004\036\027\017\016 \027\036 \017\f\023\024\035\034\024\r\026)Tj 0 Tw (-)Tj 0.13 Tw T* (\035\017. \200)Tj /Span<>> BDC ( )Tj EMC (\024\021\024\002\030\026\027\027\t\b \f\021\026\021\034\016\b \023\030\024\ \r\024\007\017\035\017 \023\024\017\f\022 \023\024)Tj /Span<>> BDC ( )Tj EMC (\002\017\002)Tj /Span<>> BDC (-)Tj EMC 0.228 Tw T* (\035\017\024\020\030\026\235\017\004\036\f\022\017\n \f\f\t\035\022\026\n\ \027\026)Tj /Span<>> BDC ( )Tj EMC (\023\030\036\007\n\036\021 \027\036\027\026\005\007\036\027\027\t\b )Tj 0.089 Tw T* (\023\030\017)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\r\024\027\026\004\026\035\034\027\024\n \023\024\017\f\022\036\ \017\f\f\035\036\007\024\r\026\027\017\005. \200)Tj /Span<>> BDC ( )Tj EMC (\f\017\f\021\036)Tj 0 Tw (-)Tj 0.318 Tw T* (\n\026\021\017\004\036\f\022\017\005 \024\002\024\030 \017)Tj /Span<>> BDC ( )Tj EMC (\n\036\021\026\026\027\026\035\017 \035\017\021\036\030\026\021\031\030\ \t \002\t\035\017 )Tj -0.02 Tw T* (\r\022\035\033\004\036\027\t \023\024\035\027\024\021\036\022\f\021\024\r\ \t\036 \f\021\026\021\034\017, \r)Tj /Span<>> BDC ( )Tj EMC (\022\024\021\024\030\t\b \024\023\017\f\026\027\t )Tj 0.108 Tw T* (\030\036\031\035\034\021\026\021\t \030\026\027\007\024\n\017\017\030\024\ \r\026\027\027\t\b \022\035\017\027\017\004\036\f\022\017\b \017\f\f\035\ \036)Tj 0 Tw (-)Tj 0.175 Tw T* (\007\024\r\026\027\017\005, \023\024\f\r\016\013\036\027\027\t\b \f\030\026\ \r\027\036\027\017\033 \n\036\f\021\027\024\020\024 \023\030\017\n\036)Tj 0 Tw (-)Tj 0.026 Tw T* [(\027\036\027\017\016 )0.5(PRP )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC [(\f\024\004\036\021\026\027\017\017 )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC [(\017\f\f\036\004\036\027\017\036\n \225\025\216 )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC (\024\021\022\030\t\021\t\n )Tj -0.017 Tw T* (\f\023\024\f\024\002\024\n \r\036\007\036\027\017\016 \030\026\027\t \017\ )Tj /Span<>> BDC ( )Tj EMC (\017\024\035\017\030\024\r\026\027\027\024\020\024 \017\f\f\036\004\036\ \027\017\016 )Tj 0 Tw T* (\225\025\216 \f)Tj /Span<>> BDC ( )Tj EMC (\024\021\022\030\t\021\t\n \f\023\024\f\024\002\024\n \r\036\007\036\027\ \017\016 \030\026\027\t.)Tj ET 0 0 0 1 K 0.5 w /GS2 gs q 1 0 0 1 303.3071 408.7912 cm 0 0 m 59.778 0 l S Q q 1 0 0 1 303.5571 339.9799 cm 0 0 m 0 68.561 l S Q q 1 0 0 1 363.0846 408.7912 cm 0 0 m 161.825 0 l S Q q 1 0 0 1 363.0846 339.9799 cm 0 0 m 0 68.561 l S Q q 1 0 0 1 524.6594 339.9799 cm 0 0 m 0 68.561 l S Q q 1 0 0 1 303.3071 339.7299 cm 0 0 m 59.778 0 l S Q q 1 0 0 1 303.5571 261.3187 cm 0 0 m 0 78.161 l S Q q 1 0 0 1 363.0846 339.7299 cm 0 0 m 161.825 0 l S Q q 1 0 0 1 363.0846 261.3187 cm 0 0 m 0 78.161 l S Q q 1 0 0 1 524.6594 261.3187 cm 0 0 m 0 78.161 l S Q q 1 0 0 1 303.3071 261.0687 cm 0 0 m 59.778 0 l S Q q 1 0 0 1 363.0846 261.0687 cm 0 0 m 161.825 0 l S Q BT /GS1 gs /T1_0 1 Tf 8 0 0 8 306.3917 400.1646 Tm (\025\030\017\021\036\030\017\017 )Tj 0 -1.2 TD (\r\022\035\033\004\036\027\017\016 )Tj T* (\r)Tj /Span<>> BDC ( )Tj EMC (\n\036\021\026\026\027\026\035\017)Tj 7.441 2.4 Td (\023\024\035\027\024\021\036\022\f\021\024\r\t\036, \030\026\027\007\024\ \n\017\017\030\024\r\026\027\027\t\036 )Tj T* (\022\035\017\027\017\004\036\f\022\017\036 \017\f\f\035\036\007\024\r\026\ \027\017\016, \023\024\f\r\016\013\036\027\027\t\036 )Tj T* (\f\030\026\r\027\036\027\017\033 \n\036\f\021\027\024\020\024 \023\030\017\ \n\036\027\036\027\017\016 PRP )Tj T* (\r)Tj /Span<>> BDC ( )Tj EMC (\f\024\004\036\021\026\027\017\017 \f)Tj /Span<>> BDC ( )Tj EMC (\017\f\f\036\004\036\027\017\036\n \225\025\216 \f)Tj /Span<>> BDC ( )Tj EMC (\024\021\022\030\t\021\t\n )Tj T* (\f\023\024\f\024\002\024\n \r\036\007\036\027\017\016 \030\026\027\t \017\ )Tj /Span<>> BDC ( )Tj EMC (\017\024\035\017\030\024\r\026\027\027\024\020\024 )Tj T* (\017\f\f\036\004\036\027\017\016 \225\025\216 \f)Tj /Span<>> BDC ( )Tj EMC (\024\021\022\030\t\021\t\n \f\023\024\f\024\002\024\n \r\036\007\036\027\ \017\016 )Tj T* (\030\026\027\t.)Tj -7.441 -1.433 Td (\025\030\017\021\036\030\017\017 )Tj T* (\017\f\022\035\033\004\036\027\017\016 )Tj T* (\017)Tj /Span<>> BDC ( )Tj EMC (\n\036\021\026\026\027\026\035\017\026)Tj 7.441 2.4 Td (\027\036\f\030\026\r\027\017\021\036\035\034\027\t\036, \027\036\030\026\ \027\007\024\n\017\017\030\024\r\026\027\027\t\036 )Tj T* (\017\f\f\035\036\007\024\r\026\027\017\016; \023\030\017\n\036\027\036\027\ \017\036 PRP \007\035\016 \035\036\004\036\027\017\016 )Tj T* (\024\f\021\030\024\020\024 \r\024\f\023\026\035\036\027\017\016 \225\025\ \216; \f\030\026\r\027\036\027\017\036 PRP )Tj T* (\f)Tj /Span<>> BDC ( )Tj EMC (\007\030\031\020\017\n\017 \n\036\021\024\007\026\n\017 \035\036\004\036\ \027\017\016 \b\030\024\027\017\004\036\f\022\024\020\024 )Tj T* (\r\024\f\023\026\035\036\027\017\016 \225\025\216; \017\024\035\017\030\ \024\r\026\027\027\024\036 \023\030\017\n\036\027\036\027\017\036 )Tj T* (PRP \007\035\016 \035\036\004\036\027\017\016 \002\024\035\034\027\t\b \023\ \026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\225\216\025 )Tj T* (\002\036 \017\f\023\024\035\034\024\r\026\027\017\016 \b\017\030\031\030\ \020\017\004\036\f\022\024\020\024 \n\036\021\024\007\026 )Tj T* (\035\036\004\036\027\017\016.)Tj /T1_2 1 Tf 10 0 0 10 303.3071 237.7098 Tm (\021\002\b\r\201\b\013\r \003\002\201\220\t)Tj /T1_0 1 Tf 0.209 Tw 0 -1.218 TD (\200 \022\026\004\036\f\021\r\036 \022\024\027\036\004\027\t\b \021\024\004\ \036\022 \023\030\024\r\036\007\036\027\027\024\020\024 \017\f\f\035\036\ \007\024)Tj 0 Tw (-)Tj 0.153 Tw T* [(\r\026\027\017\016 )0.5(\n\t )0.5(\024\002\024\027\026\004\017\035\017 )0.5(\f\035\036\007\031\033\013\017\036 )0.5(\023\026\030\026\n\036\021\030\t: )0.5(\f\030\036\007)]TJ 0 Tw (-)Tj 0.146 Tw T* (\027\017\005 \024\002\255\036\n \023\024\f\035\036\024\023\036\030\026\006\ \017\024\027\027\024\005 \030\026\027\t \027\026)Tj /Span<>> BDC ( )Tj EMC (0, 5, 10, 15 )Tj 0.063 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC 0.813 0 Td (20)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(\f\031\021\022\017 )0.5(\023\024\f\035\036 )0.5(\024\023\036\030\026\006\017\017; )0.5(\f\030\024\022 )0.5(\026\032\017\r\035\036\027\017\016 )0.6(\023\024\f\035\036)]TJ 0 Tw (-)Tj 0.492 Tw -2.109 -1.218 Td [(\024\023\036\030\026\006\017\024\027\027\024\005 )0.6(\030\026\027\t; )0.5(\f\030\036\007\027\016\016 )0.6(\023\030\024\007\024\035\032\017\021\036\035\034\027\024\f\021\034 )]TJ 0.17 Tw T* [(\002\024\035\017; \004\026\f\021\024\021\026 \030\026\r\017\021\017\016\ )0.5(\023\024\f\035\036\024\023\036\030\026\006\017\024\027\027\t\b \024\f\035\ \024\032)]TJ 0 Tw (-)Tj 0.297 Tw T* (\027\036\027\017\005 \(\017\027\235\017\006\017\030\024\r\026\027\017\036\ \030\026\027\t\); \023\030\024\007\024\035\032\017\021\036\035\034\027\024\ \f\021\034 )Tj 0 Tw T* (\023\036\030\017\024\007\026 \r\030\036\n\036\027\027\024\005 \027\036\021\ \030\031\007\024\f\023\024\f\024\002\027\024\f\021\017.)Tj /T1_3 1 Tf 0 -2.436 TD (\026\b\020\b\007\017\b\007\006\005\017\004\007\003 \020\002\020\001\007\ )Tj /T1_0 1 Tf 0.364 Tw 0 -1.218 TD (\224\021\026\021\017\f\021\017\004\036\f\022\031\033 \024\002\030\026\002\ \024\021\022\031 \007\026\027\027\t\b \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\f\030\026\r\027\036\027\017\017 )Tj 0.225 Tw T* (\020\030\031\023\023 \r\024 \r\022\035\033\004\036\027\027\t\b \r)Tj /Span<>> BDC ( )Tj EMC (\n\036\021\026\026\027\026\035\017 \017\f\f\035\036\007\024\r\026\027\017\ \016\b )Tj 0.288 Tw T* (\r\t\023\024\035\027\016\035\017 \r)Tj /Span<>> BDC ( )Tj EMC [(\023\030\024\020\030\026\n\n\036 R)13(ev)-16(iew Mana)-17(ger \(R)13(evMan\) )]TJ 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 0 Tw 7.5 0 0 7.5 70.8661 759.8869 Tm [(\007\003\032)50(\n\n\217\n)-21(\035\030\002)]TJ 53.418 0 Td [(MET)30(A)-41(-)-41.9(ANAL)30(Y)30(SIS)]TJ -53.418 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 2)69(4, \023\0224, 202)23(5)]TJ 43.013 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 2)69(4, \023\0224, 202)23(5)]TJ /T1_5 1 Tf 25 0 0 25 20.8528 56.0378 Tm (140)Tj ET endstream endobj 1493 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\007\016\b)-10(\026\215\025\016 \222\201\021\024\016\215\016\215\021\016 \001\200)-20(\026)11(\025\222\t\001\213\024\220, \025\235\025\202)10(\001\232\016\215\215\025\207 \026\201\025\024\235\025\212\021\026)11(\001\024\021, )]TJ 0 -1 TD [(\017\001\017 \b\222\025\b\025\235 \200\t\200\f\020\016\215\021\004 \201\016\ \213)21.1(\200\t\214)21(\026)11(\001\026)11(\025\r \025\222\016\201\001\026\021\r\215\025\202)10(\025 \t\016\f\016\215\021\004 )]TJ T* [(\201\025\215\021\f\016\b\017)10.1(\025\202)10(\025 \r\025\b\222\001\t\016\215\021\004 \242\222\021\026)11(\016\t\021\001\t\214\215\025\202)10.1(\025 \017)10(\025\222\f\021\017)10(\025\r\025\202)10(\025 \025\211\001 )]TJ T* [(\(\b\021\b)-10(\026)11(\016\024\001\026\021\f\016\b\017\021\207 \025\235\213\025\201 \t\021\026\ )11(\016\201\001\026)-20(\200\201\220 \021\022\024\016\026)11(\001\001\215\001\t\021\213\))]TJ 41.398 3 Td (A platelet rich plasma for pilonidal sinus disease )Tj 4.085 -1 Td [(\(s)10(y)10(stematic r)31(e)11(vie)11(w and meta-analy)10(sis\))]TJ ET 0 0 0 1 K 1 j 1 J [0 2.997]0 d /GS1 gs q 1 0 0 1 46.0167 404.5705 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 43.0197 404.5705 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q [0 2.997]0 d q 1 0 0 1 46.0167 376.9627 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 43.0197 376.9627 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q 0 j 0 J q 1 0 0 1 42.5197 322.8935 cm 0 0 m 453.543 0 l S Q BT /GS0 gs /T1_0 1 Tf 0.023 Tw 18 0 0 18 96.1527 723.8861 Tm (A platelet rich plasma for pilonidal sinus disease )Tj 2.089 -1.167 Td [(\(s)10(y)10(stematic r)31(e)11(vie)11(w and meta-analy)10.1(sis\))]TJ 0 0 0 1 k /GS1 gs 0 Tw 14 0 0 14 42.5197 678.3822 Tm [(Anastasia\022)-23.2(S.\022)-23.3(Br)21(agina)]TJ 8.162 0 0 8.162 159.1316 683.0442 Tm (1)Tj 0.023 Tw 14 0 0 14 163.7676 678.3822 Tm [(, Roman\022)-23.2(Y)39.9(u.\022)-23.2(Khr)-31(y)10(ukin)]TJ 0 Tw 8.162 0 0 8.162 284.8079 683.0442 Tm (2)Tj 0.023 Tw 14 0 0 14 289.4438 678.3822 Tm [(, Iv)10(an\022)-23.3(S.\022)-23.2(Anosov)]TJ 0 Tw 8.162 0 0 8.162 381.5747 683.0442 Tm (2)Tj 14 0 0 14 386.2107 678.3822 Tm (, )Tj -24.549 -1.143 Td [(Alek)11(sandr\022)-23.2(Y)40(u.\022)-23.3(Titov)]TJ 8.162 0 0 8.162 149.57 667.0442 Tm (2)Tj 5.83 0 0 5.83 42.5197 648.043 Tm (1)Tj 0.023 Tw 10 0 0 10 45.8311 644.713 Tm [(V)30(or)20(one)21(zh Regional Clinical Hospital \0231 \(Mosk)11(ov)10(skij av)6(., 1)113(5)127(1)69(, V)30(or)20(one)21.1(zh, 3)11(9)80(4066, Russia\))]TJ 0 Tw ( )Tj 5.83 0 0 5.83 42.5197 636.043 Tm (2)Tj 0.023 Tw 10 0 0 10 45.8311 632.713 Tm [(R)20(y)21(zhikh National Medical Resear)31(ch Center of\022)-23.3(Colopr)20.1(octology \(Saly)21(ama Adily)21(a\022)-23.3(st., 2, Moscow)22(, 1)125(23)58(423, Russia\))]TJ /T1_1 1 Tf 0.081 Tw 9 0 0 9 90.7087 614.209 Tm (AIM: to)Tj /Span<>> BDC ( )Tj EMC [(com)16(pare the)]TJ /Span<>> BDC ( )Tj EMC [(ef)-40(f)-42.9(icacy \(w)12(ound healing\) and safety \(w)12(ound infection\) betw)12(een traditional treatment af)-46(ter )]TJ 0.023 Tw 0 -1.111 TD [(open access for pilonid)26(al sinus \(PS\) and with use of)]TJ /Span<>> BDC ( )Tj EMC [(platelet-r)-36.9(ich plas)33.1(ma \(P)66(RP\).)]TJ 0.093 Tw T* [(MA)45(TERIAL A)53(ND METHODS: a)]TJ /Span<>> BDC ( )Tj EMC [(systematic revie)10(w and meta-analysis of)]TJ /Span<>> BDC ( )Tj EMC [(clinical research d)26(ata w)13(as conducted to)]TJ /Span<>> BDC ( )Tj EMC (com)Tj 0 Tw (-)Tj 0.087 Tw T* (pare lay)Tj /Span<>> BDC ( )Tj EMC (\227 open method with the)Tj /Span<>> BDC ( )Tj EMC (use of)Tj /Span<>> BDC ( )Tj EMC [(P)66(RP and lay)]TJ /Span<>> BDC ( )Tj EMC (\227 open method without the)Tj /Span<>> BDC ( )Tj EMC (use of)Tj /Span<>> BDC ( )Tj EMC [(P)66(RP for the)]TJ /Span<>> BDC ( )Tj EMC (treatment )Tj 0.013 Tw T* (of)Tj /Span<>> BDC ( )Tj EMC (PS. The)Tj /Span<>> BDC ( )Tj EMC [(meta-analysis included 4 randomized clinical tr)-37(ials and obtained d)26(ata on the)]TJ /Span<>> BDC ( )Tj EMC (results of)Tj /Span<>> BDC ( )Tj EMC (treatment of)Tj /Span<>> BDC ( )Tj EMC (299 )Tj 0.023 Tw 0 -1.111 TD [(patients. How)12(ev)13(er)61(, almost all the)]TJ /Span<>> BDC ( )Tj EMC (publications show a)Tj /Span<>> BDC ( )Tj EMC [(high r)-36.9(isk of)]TJ /Span<>> BDC ( )Tj EMC (bias in their results.)Tj -0.022 Tw 0 -1.111 TD [(RESUL)30(T)-10(S: the)]TJ /Span<>> BDC ( )Tj EMC [(meta-analysis rev)13(ealed a)]TJ /Span<>> BDC ( )Tj EMC [(statistically signif)-43(icant rev)13(ealed of)]TJ /Span<>> BDC ( )Tj EMC (lay)Tj /Span<>> BDC ( )Tj EMC (\227 open method with the)Tj /Span<>> BDC ( )Tj EMC (use of)Tj /Span<>> BDC ( )Tj EMC [(P)66(RP in )]TJ 0.023 Tw T* [(reducing w)12(ound area on d)25.9(ays 10 \(MD)]TJ /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (3.68, 95% \207I: 3.29\2264,06, p)Tj /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (0.00001\), 15 \(MD)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (5.73, 95% \207I: 2.94\2268.53, )Tj 0.048 Tw T* (p)Tj /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (0.00001\) and 20 \(MD)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (6.62, 95% \207I: 6.14\2267.10, p)Tj /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC [(0,00001\) af)-45.9(ter surg)12(er)-43(y)42(, as w)12(ell as reducing w)12(ound heal)]TJ 0 Tw (-)Tj 0.074 Tw T* (ing time \(MD)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (19.01, 95% CI: 6.40\22631.63, p)Tj /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (0.000001\) and pain duration \(MD)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (10.46, 95% \207I: 2.20\22618.72, )Tj 0.088 Tw T* (p)Tj /Span<>> BDC ( )Tj EMC 0.799 0 Td (<)Tj /Span<>> BDC ( )Tj EMC [(0.00001\), and )0.5(a)]TJ /Span<>> BDC ( )Tj EMC 7.654 0 Td [(shor)-40(ter )0.5(per)-37(iod )0.5(of)]TJ /Span<>> BDC ( )Tj EMC [(retur)-13.9(n to)]TJ /Span<>> BDC ( )Tj EMC 10.91 0 Td [(w)12(ork )0.5(\(MD)]TJ /Span<>> BDC ( )Tj EMC 4.102 0 Td (=)Tj /Span<>> BDC ( )Tj EMC [(12.80, )0.5(95% )0.5(CI: 3.62\22621.98, p)]TJ /Span<>> BDC ( )Tj EMC 13.024 0 Td (<)Tj /Span<>> BDC ( )Tj EMC [(0,00001\) com)16(pared )]TJ 0.021 Tw -36.489 -1.111 Td [(with )0.5(the)]TJ /Span<>> BDC ( )Tj EMC (lay)Tj /Span<>> BDC ( )Tj EMC [(\227 open method )0.5(without )0.5(the)]TJ /Span<>> BDC ( )Tj EMC 16.335 0 Td [(use )0.5(of)]TJ /Span<>> BDC ( )Tj EMC [(P)66(RP for )0.5(the)]TJ /Span<>> BDC ( )Tj EMC [(treatment )0.5(of)]TJ /Span<>> BDC ( )Tj EMC 12.453 0 Td [(PS. There w)13(as no )0.5(signif)-43(icant )0.5(dif)-40(ference in )]TJ 0.023 Tw -28.788 -1.111 Td (the)Tj /Span<>> BDC ( )Tj EMC (incidence of)Tj /Span<>> BDC ( )Tj EMC [(w)12(ound infection betw)12(een the)]TJ /Span<>> BDC ( )Tj EMC [(tw)12(o com)16(par)-37(ison g)14(roups \(MD)]TJ /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (3.92, 95% CI: 1.01\22615.22, p)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0.05\).)Tj 0.029 Tw T* [(C)21(ON)22(CLUSION: )0.5(topical application )0.5(of)]TJ /Span<>> BDC ( )Tj EMC 14.086 0 Td [(P)66(RP in combination )0.5(with pilonid)26.1(al sinus e)-15(xcision follow)11.9(ed by open w)12(ound man)]TJ 0 Tw (-)Tj 0.066 Tw -14.086 -1.111 Td [(ag)12(ement rep)46.1(resents an)]TJ /Span<>> BDC ( )Tj EMC [(ef)-40(fectiv)13.1(e and safe treatment app)46(roach for chronic inf)-22(lammation in pilonid)26(al sinus disease. )]TJ -0.002 Tw T* (Due to)Tj /Span<>> BDC ( )Tj EMC [(the high heterog)12(eneity of)]TJ /Span<>> BDC ( )Tj EMC [(the analyzed d)26(ata, as w)12(ell as the)]TJ /Span<>> BDC ( )Tj EMC [(poor q)14(uality of)]TJ /Span<>> BDC ( )Tj EMC (studies included in meta-analyses, )Tj 0.039 Tw T* (it is essential to)Tj /Span<>> BDC ( )Tj EMC [(treat results with caution. F)24(ur)-40(ther randomized controlled tr)-37(ials are needed to)]TJ /Span<>> BDC ( )Tj EMC [(av)13(oid incor)-16(rect con)]TJ 0 Tw (-)Tj T* (clusions.)Tj /T1_2 1 Tf 0.01 Tc -0.01 Tw 8 0 0 8 42.5596 428.9398 Tm [(KEYW)22(ORDS:)]TJ /T1_1 1 Tf 0 Tc 0.023 Tw 4.948 0 Td [( epithelial coccyg)12(eal sinus, sacrococcyg)12.1(eal pilonid)26(al sinus, P)66(RP)125(, plateletr)-36.9(ich plas)33(ma, plateletr)-36.9(ich plas)33(ma g)12(el, autologous)]TJ /T1_2 1 Tf 0.01 Tc 0.018 Tw -4.948 -1.909 Td [(C)19(ONFL)-33(ICT)5( OF)]TJ /Span<>> BDC 5.312 0 Td ( )Tj EMC [(INTE)25(REST)61.9(:)]TJ /T1_1 1 Tf 0 Tc 0.023 Tw 4.559 0 Td ( the)Tj /Span<>> BDC ( )Tj EMC [(authors declare no conf)-22(lict of)]TJ /Span<>> BDC ( )Tj EMC (interest)Tj /T1_2 1 Tf 0.037 Tc 0.014 Tw -9.871 -2.617 Td [(F)3.2(O)-4.6(R)8.7( C)-17.5(I)-15.6(T)45.4(A)37.5(T)-24.5(I)-1.2(ON:)]TJ /T1_3 1 Tf 0.023 Tc 0.023 Tw 6.459 0 Td [( B)-6(r)-30.8(a)-10.8(g)-28.9(i)-3.2(n)-7.8(a)]TJ /Span<>> BDC ( )Tj EMC [(A)-23(.)-26.9(S)-9.6(.)-23.5(, K)-20.5(h)-6.6(r)-60.6(y)-21.5(u)-9.6(k)-41.1(i)-3.1(n R)-21.4(.)51.7(Y)12.6(u)-9(.)-23.5(, A)-12.6(n)-11.9(o)-15.8(s)-19.1(o)-10.3(v)]TJ /Span<>> BDC ( )Tj EMC [(I)-10.3(.)-26.9(S)-9.6(.)-23.5(, T)-17.3(i)-15.8(t)-21.9(o)-10.3(v A)-23(.)51.6(Y)12.6(u)-9(. A)]TJ /Span<>> BDC ( )Tj EMC [(p)-20.1(l)-37.8(a)-18.2(t)-24.7(e)-18(l)-23.6(e)-22.3(t r)-56.4(i)-5(c)-10.2(h p)-20.1(l)-37.8(a)-26.6(s)-6.6(m)-8.3(a f)-25.2(o)-11.8(r p)-18.6(i)-7.1(l)-20.9(o)-9.2(n)-14(i)-8.8(d)-9.3(a)-11.4(l s)-26.1(i)-3.2(n)-7.7(u)-21.9(s d)-15.8(i)-7.4(s)-22.9(e)-13(a)-26.6(s)-22.9(e \()28.9(s)-30.8(y)-28.9(s)-29.3(t)-24.7(e)-11.5(m)-8.3(a)-18.2(t)-46.2(i)-5(c)23( )]TJ 0.024 Tc -0.043 Tw -6.464 -1.2 Td [(r)-11.1(e)-7.9(v)-43.8(i)-3(e)-4.5(w)7.6( an)-6.5(d)7.7( m)-8.6(e)-14.4(t)-28.8(a)-11.6(-)-5.1(ana)-3.4(ly)-20.9(s)-18.1(i)0.5(s)49.5(\))18.4(.)7.7( )]TJ /T1_1 1 Tf 0.026 Tc -0.026 Tw [(K)13.9(ol)3.6(op)2.3(r)3.1(o)3.4(k)-19.2(t)2.2(ol)3.6(o)-3.3(g)-13.3(i)6.7(a)5.8(.)]TJ /T1_3 1 Tf 0.016 Tc -0.035 Tw 18.534 0 Td [( 2)-8.9(0)-3.8(2)-1.5(5)23.3(;)9.8(2)8.8(4)-13.6(\()40.1(4)30.3(\))14.4(:)20.9(1)-7.9(3)-15.9(8)-24.3(\226)50.8(1)0.9(5)38.1(1)4.2(. \()-0.9(i)-3.2(n R)-6.6(u)-21.9(s)-22.3(s)-15.5(.)43.1(\))10.4(. h)-17.2(t)-49.4(t)-29.5(p)-18.7(s)-8(:)1.9(/)84.6(/)36.4(d)-11.1(o)-12.5(i.)2.7(o)-11.8(r)-16.7(g)-22.8(/)11.1(1)14(0)6.5(.)-5.7(3)7.9(3)-15.9(8)1.2(7)4.6(8/)7.9(2)-9(0)9.3(7)-1.9(3)-13.4(-)41.2(7)10.7(55)-9(6)-26.7(-)9.7(2)-9(0)-3.8(2)-1.4(5)-23.6(-)9.7(2)8.8(4)-28.5(-)-30.3(4)-28.6(-)55.1(1)-7.9(3)-16(8)-25.7(-)55.1(1)0.8(5)38.2(1)]TJ /T1_2 1 Tf 0.01 Tc -0.037 Tw -18.529 -2.617 Td [(\021\024\027\030\026)5( \024\033\023)5( \t\030\027\030\t\032\026\037\032:)]TJ /T1_1 1 Tf 0 Tc -0.032 Tw 10.466 0 Td [( \212\033\026\021\022\020 \213\034\006\037\020 \234\033\003\016\036\022\005\ , \216\223\210\215 \253\217\214\200\221 \021\034\027\034\f\033\034\021\035\ \034\027\034\013\022\022 )0.5(\022\006\016\020\022 \205.\217.)]TJ /Span<>> BDC ( )Tj EMC [(\213\032\201\022\002\273 \214\022\020\031\b\033\037\036\037 )0.5(\213\034\024\024\022\022, \023\027.)]TJ /Span<>> BDC ( )Tj EMC [(\207\037\027\030\006\037 )0.5(\205\b\022\027\030, )]TJ 0.023 Tw -10.471 -1.2 Td (\b.)Tj /Span<>> BDC ( )Tj EMC (2, \214\034\024\021\036\037, 123423, \035\016\027.:)Tj /Span<>> BDC ( )Tj EMC (+7 \(916\) 159-80-59; e-mail: hrukin_ru@gnck.ru)Tj /T1_2 1 Tf 0.01 Tc 0.039 Tw 0.005 -1.2 Td [(ADDRESS)5( F)13(OR)5( C)19(ORRESPONDEN)23(CE:)]TJ /T1_1 1 Tf 0 Tc 0.044 Tw 14.093 0 Td [( Khr)-43(yukin R)19.1(oman Y)39(ur)-43(yevich, Ryzhikh N)18(ational Medical R)21.1(esearch Center of)]TJ /Span<>> BDC ( )Tj EMC [(Colop)46(roctology)42(, Salyama Adilya st., )]TJ 0.023 Tw -14.098 -1.2 Td [(2, Moscow)52(, 123423, phone number:)]TJ /Span<>> BDC ( )Tj EMC (+7 \(916\) 159-80-59; e-mail: hrukin_ru@gnck.ru.)Tj 0 Tw 0 -2.792 TD (\n\037\035\037 \f\034\024\035\023\f\027\016\020\022\030)Tj /Span<>> BDC ( )Tj EMC (\227 19.06.2025)Tj /Span<>> BDC ( )Tj EMC 19.488 0 Td (\t\034\024\027\016 \b\034\033\037\025\034\035\021\022)Tj /Span<>> BDC ( )Tj EMC (\227 27.08.2025)Tj /Span<>> BDC ( )Tj EMC 18.78 0 Td (\t\033\022\020\030\035\034 \021)Tj /Span<>> BDC ( )Tj EMC (\f\023\025\027\022\021\037\007\022\022)Tj /Span<>> BDC ( )Tj EMC (\227 10.11.2025)Tj ( )Tj -38.268 -1.375 Td (Received)Tj /Span<>> BDC ( )Tj EMC (\227 19.06.2025)Tj /Span<>> BDC ( )Tj EMC 19.488 0 Td (Revised)Tj /Span<>> BDC ( )Tj EMC (\227 27.08.2025)Tj /Span<>> BDC ( )Tj EMC 18.78 0 Td (Accepted for publication)Tj /Span<>> BDC ( )Tj EMC (\227 10.11.2025)Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 42.5896 262.0659 Tm (\023\023\034\226\034\022\031\034)Tj 0 0 0 1 k /GS1 gs /T1_3 1 Tf 0 Tc -0.005 Tw 10 0 0 10 42.5197 237.7099 Tm (\216\030\024\027\017\004\036\f\022\024\036 \r\024\f\023\026\035\036\027\017\ \036 \220\023\017\021\036\035\017\026\035\034\027\024\020\024 \022\024\023\ \004\017\022\024\r\024)Tj 0 Tw (-)Tj 0.128 Tw 0 -1.218 TD (\020\024 \b\024\007\026 \(\225\025\216\))Tj /Span<>> BDC ( )Tj EMC (\227 \220\021\024 \026\002\024\035\036\r\026\027\017\036 \f)Tj /Span<>> BDC ( )Tj EMC (\030\026\f\023\030\024\f\021\030\026\027\036\027)Tj 0 Tw (-)Tj 0.083 Tw T* (\027\024\f\021\034\033 26\22648)Tj /Span<>> BDC ( )Tj EMC (\027\026)Tj /Span<>> BDC ( )Tj EMC (100000 \004\036\035\024\r\036\022, \022\024\021\024\030\024\036 \023\024\ \030\026\032\026\036\021 )Tj 0.13 Tw T* (\023\026\006\017\036\027\021\024\r \r)Tj /Span<>> BDC ( )Tj EMC (\r\024\030\026\f\021\036 \024\021 15 \007\024)Tj /Span<>> BDC ( )Tj EMC (30 \035\036\021 [1], \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\n )Tj 0.159 Tw T* (\n\031\032\004\017\027\t \002\024\035\036\033\021 \004\026\013\036 \023\024\ )Tj /Span<>> BDC ( )Tj EMC (\f\030\026\r\027\036\027\017\033 \f)Tj /Span<>> BDC ( )Tj EMC (\032\036\027\013\017\027\026\n\017 )Tj 0 Tw T* ([2\2263].)Tj 0.224 Tw T* (\224\024\020\035\026\f\027\024 \022\035\017\027\017\004\036\f\022\017\n \ \030\036\022\024\n\036\027\007\026\006\017\016\n \023\024)Tj /Span<>> BDC ( )Tj EMC (\007\017\026\020\027\024\f)Tj 0 Tw (-)Tj -0.087 Tw T* (\021\017\022\036 \017)Tj /Span<>> BDC ( )Tj EMC (\035\036\004\036\027\017\033 \225\025\216 [1], \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\f\031\013\036\f\021\r\024\r\026\027\017\017 \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\026 )Tj 0.031 Tw T* (\017\r\017\021\024\020\024 \225\025\216 \f)Tj /Span<>> BDC ( )Tj EMC (\020\027\024\005\027\t\n\017 \026\021\036\022\026\n\017, \r\021\024\030\ \017\004\027\t\n\017 \f\r\017)Tj 0 Tw (-)Tj 0.06 Tw T* (\013\036\r\t\n\017 \024\021\r\036\030\f\021\017\016\n\017 \017)Tj /Span<>> BDC ( )Tj EMC (\r\t\030\026\032\036\027\027\024\005 \r\024\f\023\026\035\017\021\036\035\ \034\027\024\005 )Tj 0.265 Tw T* (\017\027\235\017\035\034\021\030\026\006\017\036\005, \r\026\030\017\026\ \027\021\024\n \r\t\002\024\030\026 \b\017\030\031\030\020\017\004\036\f\ \022\024\020\024 )Tj 0.174 Tw T* [(\r\n\036\001\026\021\036\035\034\f\021\r\026 )0.6(\016\r\035\016\036\021\f\016 )0.5(\017\f\f\036\004\036\027\017\036 )0.6(\225\025\216 )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC 18.084 0 Td (\024\021\022\030\t\021\t\n )Tj 0.013 Tw -18.084 -1.218 Td (\f\023\024\f\024\002\024\n \r\036\007\036\027\017\016 \030\026\027\t, \023\ \030\017)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\n, \f\030\024\022\017 \026\032\017\r\035\036\027\017\016 )Tj -0.022 Tw T* (\023\024\f\035\036\024\023\036\030\026\006\017\024\027\027\024\020\024 \007\ \036\235\036\022\021\026 \022\024\035\036\002\035\033\021\f\016 \r)Tj /Span<>> BDC ( )Tj EMC (\023\030\036\007\036\035\026\b )Tj 0.079 Tw 23.244 18.267 Td (\024\021 30,1 \007\024)Tj /Span<>> BDC ( )Tj EMC (78,7 \007\027\036\005 [3\2266], \004\021\024 \r\035\036\004\036\021 \026\ )Tj /Span<>> BDC ( )Tj EMC (\f\024\002\024\005 \007\035\017)Tj 0 Tw (-)Tj 0.559 Tw T* (\021\036\035\034\027\t\005 \023\036\030\017\024\007 \r\030\036\n\036\027\ \027\024\005 \027\036\021\030\031\007\024\f\023\024\f\024\002\027\024\f\021\ \017. )Tj 0.142 Tw T* (\225\021\024\021 \235\026\022\021 \023\024\007\004\036\030\022\017\r\026\ \036\021 \027\036 \021\024\035\034\022\024 \f\024\006\017\026\035\034\027\ \031\033 \027\026)Tj 0 Tw (-)Tj 0.06 Tw T* (\004\017\n\024\f\021\034 \007\026\027\027\024\005 \027\024\024\035\024\020\ \017\017, \027\024 \017)Tj /Span<>> BDC ( )Tj EMC (\024\023\030\036\007\036\035\016\036\021 \027\036\024\002\b\024)Tj 0 Tw (-)Tj -0.028 Tw T* (\007\017\n\024\f\021\034 \023\024\017\f\022\026 \220\235\235\036\022\021\ \017\r\027\024\005 \017)Tj /Span<>> BDC ( )Tj EMC (\002\036\024\023\026\f\027\024\005 \n\036\021\024\007\017\022\017 )Tj 0.041 Tw T* (\035\036\004\036\027\017\016, \027\026\023\030\026\r\035\036\027\027\024\ \005 \027\026)Tj /Span<>> BDC ( )Tj EMC (\f\027\017\032\036\027\017\036 \f\030\024\022\024\r \r\030\036\n\036\027\ )Tj 0 Tw (-)Tj T* (\027\024\005 \027\036\021\030\031\007\024\f\023\024\f\024\002\027\024\f\021\ \017.)Tj 0.183 Tw T* (\215\030\017\n\036\027\036\027\017\036 \026\031\021\024\023\035\026\n\t\ , \024\002\024\020\026\013\036\027\027\024\005 \021\030\024\n\002\024\006\ \017\021\026)Tj 0 Tw (-)Tj 0.224 Tw T* (\n\017 \(PRP\), \026\030\036\022\024\n\036\027\007\024\r\026\035\024 \f\ \036\002\016 \022\026\022 \220\235\235\036\022\021\017\r\027\t\005 )Tj 0.015 Tw T* (\f\023\024\f\024\002 \f\024\022\030\026\013\036\027\017\016 \023\036\030\ \017\024\007\026 \026\032\017\r\035\036\027\017\016 \030\026\027 \017)Tj /Span<>> BDC ( )Tj EMC (\023\024\007\026)Tj 0 Tw (-)Tj 0.035 Tw T* (\r\035\036\027\017\016 \024\004\026\020\026 \r\024\f\023\026\035\036\027\ \017\016 \023\024\f\035\036 \r\t\023\024\035\027\036\027\027\t\b \b\017\030\ \031\030)Tj 0 Tw (-)Tj 0.05 Tw T* (\020\017\004\036\f\022\017\b \r\n\036\001\026\021\036\035\034\f\021\r \r\ )Tj /Span<>> BDC ( )Tj EMC (\030\026\027\t\b \024\021\030\026\f\035\016\b \n\036\007\017\006\017\027\ \t )Tj -0.016 Tw T* ([7], \r)Tj /Span<>> BDC ( )Tj EMC (\021\024\n \004\017\f\035\036 \023\024\f\035\036 \017\f\f\036\004\036\027\ \017\016 \225\025\216 \f)Tj /Span<>> BDC ( )Tj EMC (\024\021\022\030\t\021\t\n \f\023\024)Tj 0 Tw (-)Tj T* (\f\024\002\024\n \r\036\007\036\027\017\016 \030\026\027\t [3\2266].)Tj 0.259 Tw T* (\224 \006\036\035\034\033 \031\035\031\004\001\036\027\017\016 \220\235\235\ \036\022\021\017\r\027\024\f\021\017 \035\036\004\036\027\017\016 \023\026\ \006\017)Tj 0 Tw (-)Tj 0.265 Tw T* (\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\b\030\024\027\017\004\036\f\022\017\n \r\024\f\023\026\035\036\027\017\036\ \n \225\025\216 \r)Tj /Span<>> BDC ( )Tj EMC (\n\017\030\024\r\024\005 )Tj ET 1 0.68 0 0.12 k /GS0 gs q 1 0 0 1 42.5197 622.7134 cm 0 0 m 0 0 l 0 -11.339 l 42.52 -11.339 l 42.52 0 l h f Q BT 0 0 0 0 k /T1_2 1 Tf 0 Tw 9 0 0 9 45.2263 613.7861 Tm (ABSTRACT)Tj 1 0.68 0 0.12 k /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\007\003\032)50(\n\n\217\n)-21(\035\030\002)]TJ 53.418 0 Td [(MET)30(A)-41(-)-41.9(ANAL)30(Y)30(SIS)]TJ /T1_5 1 Tf 25 0 0 25 505.4895 56.0378 Tm (139)Tj ET endstream endobj 1490 0 obj [1495 0 R] endobj 1491 0 obj <>stream q /GS0 gs /Fm0 Do Q 0 0 0 1 K 1 j 1 J [0 2.997]0 d /GS1 gs q 1 0 0 1 74.3631 135.4104 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 71.3661 135.4104 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q [0 2.997]0 d q 1 0 0 1 74.3631 98.2025 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 71.3661 98.2025 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q BT 0 0 0 1 k /T1_0 1 Tf 10 0 0 10 70.8661 724.8299 Tm (https://doi.org/10.33878/2073-7556-2025-24-4-138-151)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0.023 Tw 19 0 0 19 103.4998 695.3259 Tm [(\007\016\b)-10(\026\215\025\016 \222\201\021\024\016\215\016\215\021\016 \001\200)-19.9(\026)11(\025\222\t\001\213\024\220, \025\235\025\202)10.1(\001\232\016\215\215\025\207 )]TJ 2.243 -1.105 Td [(\026\201\025\024\235\025\212\021\026)11(\001\024\021, \017\001\017 \b\222\025\b\025\235 \200\t\200\f\020\016\215\ \021\004 )]TJ -2.277 -1.105 Td [(\201\016\213)21(\200\t\214)21(\026)11(\001\026)11(\025\r \025\222\016\201\001\026\021\r\215\025\202)10(\025 \t\016\f\016\215\021\004 \201\025\215\021\f\016\b\017)10(\025\202)10.1(\025 )]TJ 0.601 -1.105 Td [(\r\025\b\222\001\t\016\215\021\004 \242\222\021\026)11(\016\t\021\001\t\214\215\025\202)10.1(\025 \017)10(\025\222\f\021\017)10(\025\r\025\202)10(\025 \025\211\001 )]TJ -1.092 -1.105 Td [(\(\b\021\b)-10(\026)11(\016\024\001\026\021\f\016\b\017\021\207\022)-23.2(\025\235\213\025\201 \t\021\026)11(\016\201\001\026)-19.9(\200\201\220 \021\022)-23.3(\024\016\026)11.1(\001\001\215\001\t\021\213\))]TJ 0 0 0 1 k /GS1 gs 0 Tw 14 0 0 14 70.8661 586.822 Tm [(\206\201\001\202\021\215\001\022)-23.2(\n)-31(.\013.)]TJ 8.162 0 0 8.162 148.0791 591.484 Tm (1)Tj 0.023 Tw 14 0 0 14 152.7151 586.822 Tm [(, \005\201\205\017\021\215\022)-23.2(\033)124(.\204.)]TJ 0 Tw 8.162 0 0 8.162 235.5184 591.484 Tm (2)Tj 0.023 Tw 14 0 0 14 240.1543 586.822 Tm [(, \n\215\025\b\025\r\022)-23.2(\030.\013.)]TJ 0 Tw 8.162 0 0 8.162 320.5214 591.484 Tm (2)Tj 0.023 Tw 14 0 0 14 325.1574 586.822 Tm [(, \032)30(\021\026)11(\025\r\022)-23.2(\n)-31(.\204.)]TJ 0 Tw 8.162 0 0 8.162 398.6926 591.484 Tm (2)Tj 5.83 0 0 5.83 70.8661 572.4827 Tm (1)Tj 0.023 Tw 10 0 0 10 74.1775 569.1527 Tm [(\206)42(\230)31(\002 \006\036 \253\006\025\201\025\215\016\216\b\017\001\004 \025\235\t\001\ \b)-9.9(\026\215\001\004 \017)-10(\t\021\215\021\f\016\b\017\001\004 \235\025\t\214\215\021\212\001 \0231\273\ \(\007\025\b\017)10(\025\r\b\017\021\207 \222\201\025\b\222\016\017)-10(\026, \211.\022)-23.3(1)113(5)127.1(1)68.9(, \202)62(.\022)-23.3(\006\025\201\025\215\016\216, )]TJ -0.331 -1.2 Td [(3)11(9)80(40)37(77)127(, \033\025\b\b\021\004\))]TJ 0 Tw ( )Tj 5.83 0 0 5.83 70.8661 548.4827 Tm (2)Tj 0.023 Tw 10 0 0 10 74.1775 545.1527 Tm [(\203\031\206)42(\230 \253\217\007\030\226 \017)10(\025\t\025\222\201\025\017)-9.9(\026)11(\025\t\025\202\021\021 \021\024\016\215\021 \n)-30.9(.\217.\022)-23.3(\033\220\216\021\273 \007\021\215\213\211\201\001\r\001 \033\025\b\b\021\ \021 \(\200\t.\022)-23.3(\013\001\t\004\024\001 \n)-20.9(\211\021\t\004, \211.\022)-23.3(2, \202)62.1(.\022)-23.3(\007\025\b\017\r\001, )]TJ -0.331 -1.2 Td [(1)125(23)58(423, \033\025\b\b\021\004\))]TJ /T1_0 1 Tf 0.165 Tw 9 0 0 9 119.0551 514.6488 Tm (\204\n\204\217\200\204: \027\016\005\016\020\022\016 \002\033\034\020\022\ \005\016\024\021\034\013\034 \036\034\024\f\037\027\016\020\022\030 \203\ \r\212 \(\220\f\022\035\016\027\022\037\027\003\020\034\013\034 \021\034\ \f\005\022\021\034\036\034\013\034 \002\034\b\037\) \024\036\030\031\037\ \020\034 \024)Tj /Span<>> BDC ( )Tj EMC (\035\037\021\022\006\022 )Tj 0.114 Tw 0 -1.111 TD [(\020\016\025\027\037\013\034\f\033\022\030\035\020\032\006\022 )0.6(\220\017\017\016\021\035\037\006\022 )0.6(\021\037\021 )0.5(\b\027\022\035\016\027\003\020\034\016 )0.6(\031\037\201\022\036\027\016\020\022\016 )0.6(\f\034\024\027\016\034\f\016\033\037\007\022\034\020\020\034\013\034 )0.5(\b\016\017\016\021\035\037, )0.5(\025\034\027\016\036\034\004 )0.5(\024\022\020\b)]TJ 0 Tw (-)Tj -0.014 Tw T* (\033\034\006, \022\020\017\022\007\022\033\034\036\037\020\022\016 \033\037\ \020\032, \037)Tj /Span<>> BDC ( )Tj EMC (\035\037\021\201\016 \f\033\034\b\034\027\201\022\035\016\027\003\020\032\ \004 \f\016\033\022\034\b \036\033\016\006\016\020\020\034\004 \020\016\035\ \033\023\b\034\024\f\034\024\034\025\020\034\024\035\022. \032\f\034\027\ \020\016\020\022\016 )Tj 0.026 Tw T* (\002\022\033\023\033\013\022\005\016\024\021\034\013\034 \036\006\016\001\ \037\035\016\027\003\024\035\036\037 \036)Tj /Span<>> BDC ( )Tj EMC (\034\025\206\016\006\016 \022\024\024\016\005\016\020\022\030 \203\r\212\ \024)Tj /Span<>> BDC ( )Tj EMC (\034\035\021\033\032\035\032\006 \024\f\034\024\034\025\034\006 \036\016\ \b\016\020\022\030 \f\034\024\027\016\034\f\016\033\037\007\022\034\020\020\ \034\004 )Tj 0.097 Tw T* (\033\037\020\032 \024)Tj /Span<>> BDC ( )Tj EMC (\006\016\024\035\020\032\006 \f\033\022\006\016\020\016\020\022\016\006 \ PRP \(\037\023\035\034\f\027\037\031\006\032, \034\025\034\013\037\235\016\ \020\020\034\004 \035\033\034\006\025\034\007\022\035\037\006\022\) \030\ \036\027\030\016\035\024\030 \f\016\033\024\f\016\021\035\022\036\020\032\ \006 )Tj 0.141 Tw T* (\020\037\f\033\037\036\027\016\020\022\016\006 \036)Tj /Span<>> BDC ( )Tj EMC (\027\016\005\016\020\022\022 \002\033\034\020\022\005\016\024\021\034\013\ \034 \036\034\024\f\037\027\016\020\022\030 \203\r\212. \t\034)Tj /Span<>> BDC ( )Tj EMC (\b\037\020\020\032\006 \027\022\035\016\033\037\035\023\033\032, \024\034\ \005\016\035\037\020\020\034\016 \036\032\f\034\027\020\016\020\022\016 \ )Tj 0.118 Tw T* [(\034\f\016\033\037\007\022\022 )0.5(\024)]TJ /Span<>> BDC ( )Tj EMC [(\006\016\024\035\020\032\006 \f\033\022\006\016\020\016\020\022\016\006 \ PRP )0.5(\b\016\006\034\020\024\035\033\022\033\023\016\035 )0.5(\024\035\037\035\022\024\035\022\005\016\024\021\022 )0.5(\031\020\037\005\022\006\034\016 \024\020\022\201\016\020\022\016 \036\016\ \033\034\030\035\020\034\024\035\022 )]TJ 0.023 Tw T* (\033\037\031\036\022\035\022\030 \034\f\022\024\037\020\020\032\002 \033\ \037\020\016\016 \020\016\013\037\035\022\036\020\032\002 \030\036\027\016\ \020\022\004.)Tj 0.056 Tw 0 -1.111 TD (\221\204\231\232: \024\033\037\036\020\022\035\003 \220\017\017\016\021\035\ \022\036\020\034\024\035\003 \(\031\037\201\022\036\027\016\020\022\016 \ \f\034\024\027\016\034\f\016\033\037\007\022\034\020\020\034\004 \033\037\ \020\032\) \022)Tj /Span<>> BDC ( )Tj EMC (\025\016\031\034\f\037\024\020\034\024\035\003 \(\005\037\024\035\034\035\ \037 \034\024\027\034\201)Tj 0 Tw (-)Tj 0.018 Tw 0 -1.111 TD (\020\016\020\022\004\) \006\016\024\035\020\034\013\034 \f\033\022\006\016\ \020\016\020\022\030 PRP \036)Tj /Span<>> BDC ( )Tj EMC (\024\034\005\016\035\037\020\022\022 \024)Tj /Span<>> BDC ( )Tj EMC (\022\024\024\016\005\016\020\022\016\006 \203\r\212 \024)Tj /Span<>> BDC ( )Tj EMC (\034\035\021\033\032\035\032\006 \024\f\034\024\034\025\034\006 \036\016\ \b\016\020\022\030 \033\037\020\032 \022)Tj /Span<>> BDC ( )Tj EMC (\022\031\034)Tj 0 Tw (-)Tj 0.023 Tw T* (\027\022\033\034\036\037\020\020\034\013\034 \022\024\024\016\005\016\020\ \022\030 \203\r\212 \024)Tj /Span<>> BDC ( )Tj EMC (\034\035\021\033\032\035\032\006 \024\f\034\024\034\025\034\006 \036\016\ \b\016\020\022\030 \033\037\020\032 \b\027\030 \027\016\005\016\020\022\030\ \002\033\034\020\022\005\016\024\021\034\013\034 \036\034\024\f\037\027\ \016\020\022\030 \203\r\212.)Tj 0.121 Tw T* (\t\205\221\200\204\217\202\233 \200)Tj /Span<>> BDC ( )Tj EMC [(\214\204\202\240\n\233: \f\033\034\036\016\b\016\020 \024\022\024\035\016\ \006\037\035\022\005\016\024\021\022\004 )0.5(\034\025\031\034\033 \027\022\035\016\033\037\035\023\033\032 \022)]TJ /Span<>> BDC ( )Tj EMC (\006\016\035\037\037\020\037\027\022\031 \b\037\020\020\032\002 \021\027\ \022\020\022\005\016\024\021\022\002 )Tj 0 Tw T* (\022\024\024\027\016\b\034\036\037\020\022\004, \024\033\037\036\020\022\ \036\037\026\235\022\002 \006\016\024\035\020\034\016 \f\033\022\006\016\ \020\016\020\022\016 PRP \036)Tj /Span<>> BDC ( )Tj EMC (\024\034\005\016\035\037\020\022\022 \024)Tj /Span<>> BDC ( )Tj EMC (\022\024\024\016\005\016\020\022\016\006 \203\r\212 \024)Tj /Span<>> BDC ( )Tj EMC (\034\035\021\033\032\035\032\006 \024\f\034\024\034\025\034\006 )Tj 0.029 Tw T* (\036\016\b\016\020\022\030 \033\037\020\032 \022)Tj /Span<>> BDC ( )Tj EMC (\022\031\034\027\022\033\034\036\037\020\020\034\016 \022\024\024\016\005\ \016\020\022\016 \203\r\212 \024)Tj /Span<>> BDC ( )Tj EMC (\034\035\021\033\032\035\032\006 \024\f\034\024\034\025\034\006 \036\016\ \b\016\020\022\030 \033\037\020\032 \b\027\030 \027\016\005\016\020\022\030\ \002\033\034\020\022\005\016\024\021\034)Tj 0 Tw (-)Tj 0.142 Tw T* [(\013\034 )0.6(\036\034\024\f\037\027\016\020\022\030 )0.6(\203\r\212. )0.5()]TJ /Span<>> BDC ( )Tj EMC 9.423 0 Td [(\006\016\035\037\037\020\037\027\022\031 )0.7(\036\021\027\026\005\016\020\034 )0.6(4 )0.5(\033\037\020\b\034\006\022\031\022\033\034\036\037\020\020\032\002 )0.7(\021\027\022\020\022\005\016\024\021\022\002 )0.6(\022\024\024\027\016\b\034\036\037\020\022\030 )0.5(\022)]TJ /Span<>> BDC ( )Tj EMC 31.685 0 Td (\f\034\027\023\005\016\020\032 )Tj 0.07 Tw -41.107 -1.111 Td (\b\037\020\020\032\016 \034)Tj /Span<>> BDC ( )Tj EMC (\033\016\031\023\027\003\035\037\035\037\002 \027\016\005\016\020\022\030\ 299 \f\037\007\022\016\020\035\034\036, \034\b\020\037\021\034 \f\033\037\ \021\035\022\005\016\024\021\022 \036\034 \036\024\016\002 \f\023\025\027\ \022\021\037\007\022\030\002 \f\033\034\024\027\016\201\022\036\037\016\035\ \024\030 )Tj 0.023 Tw T* (\036\032\024\034\021\022\004 \033\022\024\021 \024\006\016\235\016\020\022\ \030 \f\034\027\023\005\016\020\020\032\002 \033\016\031\023\027\003\035\ \037\035\034\036.)Tj 0.123 Tw 0 -1.111 TD (\213\204\255\215\231\232\202\205\202\233: \036)Tj /Span<>> BDC ( )Tj EMC (\002\034\b\016 \f\033\034\036\016\b\016\020\020\034\013\034 \006\016\035\ \037\037\020\037\027\022\031\037 \b\034\021\037\031\037\020\034 \024\035\ \037\035\022\024\035\022\005\016\024\021\022 \031\020\037\005\022\006\034\ \016 \f\033\016\022\006\023\235\016\024\035\036\034 \006\016\024\035)Tj 0 Tw (-)Tj 0.03 Tw 0 -1.111 TD (\020\034\013\034 \f\033\022\006\016\020\016\020\022\030 PRP \036)Tj /Span<>> BDC ( )Tj EMC (\024\034\005\016\035\037\020\022\022 \024)Tj /Span<>> BDC ( )Tj EMC (\022\024\024\016\005\016\020\022\016\006 \203\r\212 \024)Tj /Span<>> BDC ( )Tj EMC (\034\035\021\033\032\035\032\006 \024\f\034\024\034\025\034\006 \036\016\ \b\016\020\022\030 \033\037\020\032 \036)Tj /Span<>> BDC ( )Tj EMC (\021\037\005\016\024\035\036\016 \023\006\016\020\003)Tj 0 Tw (-)Tj 0.061 Tw T* (\001\016\020\022\030 \034\025\206\016\006\037 \033\037\020\016\036\034\013\ \034 \b\016\017\016\021\035\037 \020\037)Tj /Span<>> BDC ( )Tj EMC (10-\016 \(\033\037\031\020\022\007\037 \024\033\016\b\020\022\002)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (3,68, 95% \n\200: 3,29\2264,06, p)Tj /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (0,00001\), \020\037)Tj /Span<>> BDC ( )Tj EMC (15-\016 )Tj 0.06 Tw T* [(\(\033\037\031\020\022\007\037 )0.6(\024\033\016\b\020\022\002)]TJ /Span<>> BDC ( )Tj EMC 7.584 0 Td (=)Tj /Span<>> BDC ( )Tj EMC 0.792 0 Td [(5,73, )0.5(95% )0.6(\n\200: )0.5(2,94\2268,53, )0.5(p)]TJ /Span<>> BDC ( )Tj EMC 11.22 0 Td (<)Tj /Span<>> BDC ( )Tj EMC 0.792 0 Td [(0,00001\) )0.5(\022)]TJ /Span<>> BDC ( )Tj EMC 4.715 0 Td [(\020\037 )0.5(20-\016 )0.6(\024\023\035\021\022\(\033\037\031\020\022\007\037 )0.6(\024\033\016\b\020\022\002)]TJ /Span<>> BDC ( )Tj EMC 13.39 0 Td (=)Tj /Span<>> BDC ( )Tj EMC 0.792 0 Td [(6,62, )0.5(95% )0.6(\n\200: )]TJ 0.142 Tw -39.286 -1.111 Td (6,14\2267,10, p)Tj /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (0,00001\)\f\034\024\027\016 \036\032\f\034\027\020\016\020\022\030 \002\022\ \033\023\033\013\022\005\016\024\021\034\013\034 \036\006\016\001\037\035\ \016\027\003\024\035\036\037, \024\020\022\201\016\020\022\030 \f\033\034\ \b\034\027\201\022\035\016\027\003\020\034\024\035\022 )Tj 0.105 Tw T* [(\031\037\201\022\036\027\016\020\022\030 )0.6(\f\034\024\027\016\034\f\016\033\037\007\022\034\020\020\034\004 )0.6(\033\037\020\032 )0.5(\(\033\037\031\020\022\007\037 )0.6(\024\033\016\b\020\022\002)]TJ /Span<>> BDC ( )Tj EMC 23.841 0 Td (=)Tj /Span<>> BDC ( )Tj EMC 0.837 0 Td [(19,01, )0.5(95% )0.5(\n\200: )0.6(6,40\22631,63, )0.5(p)]TJ /Span<>> BDC ( )Tj EMC 12.445 0 Td (<)Tj /Span<>> BDC ( )Tj EMC 0.837 0 Td [(0,000001\) )0.5(\022)]TJ /Span<>> BDC ( )Tj EMC 5.305 0 Td (\b\027\022)Tj 0 Tw (-)Tj 0.056 Tw -43.266 -1.111 Td [(\035\016\027\003\020\034\024\035\022 )0.5(\025\034\027\016\036\034\013\034 )0.5(\024\022\020\b\033\034\006\037 )0.5(\(\033\037\031\020\022\007\037 \024\033\016\b\020\022\002)]TJ /Span<>> BDC ( )Tj EMC 20.735 0 Td (=)Tj /Span<>> BDC ( )Tj EMC [(10,46, 95% \n\200: )0.5(2,20\22618,72, p)]TJ /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (0,00001\), \037)Tj /Span<>> BDC ( )Tj EMC (\035\037\021\201\016 \024\034\021\033\037)Tj 0 Tw (-)Tj 0.025 Tw -20.735 -1.111 Td (\235\016\020\022\030 \f\016\033\022\034\b\037 \036\033\016\006\016\020\020\ \034\004 \020\016\035\033\023\b\034\024\f\034\024\034\025\020\034\024\035\ \022 \(\033\037\031\020\022\007\037 \024\033\016\b\020\022\002)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (12,80, 95% \n\200: 3,62\22621,98, p)Tj /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (0,00001\) )Tj 0.076 Tw T* (\f\034)Tj /Span<>> BDC ( )Tj EMC (\024\033\037\036\020\016\020\022\026 \024)Tj /Span<>> BDC ( )Tj EMC (\022\031\034\027\022\033\034\036\037\020\020\032\006 \022\024\024\016\005\ \016\020\022\016\006 \203\r\212 \024)Tj /Span<>> BDC ( )Tj EMC (\034\035\021\033\032\035\032\006 \024\f\034\024\034\025\034\006 \036\016\ \b\016\020\022\030 \033\037\020\032 \b\027\030 \027\016\005\016\020\022\030\ \002\033\034\020\022\005\016)Tj 0 Tw (-)Tj -0.023 Tw 0 -1.111 TD (\024\021\034\013\034 \036\034\024\f\037\027\016\020\022\030 \203\r\212. \ \207\035\037\035\022\024\035\022\005\016\024\021\022 \031\020\037\005\022\ \006\034\004 \033\037\031\020\022\007\032 \006\016\201\b\023 \013\033\023\ \f\f\037\006\022 \024\033\037\036\020\016\020\022\030 \036)Tj /Span<>> BDC ( )Tj EMC (\034\035\020\034\001\016\020\022\022 \005\037\024\035\034\035\032 )Tj 0.001 Tw 0 -1.111 TD (\033\037\031\036\022\035\022\030 \f\034\024\027\016\034\f\016\033\037\007\ \022\034\020\020\032\002 \034\024\027\034\201\020\016\020\022\004 \(\022\ \020\017\022\007\022\033\034\036\037\020\022\016 \033\037\020\032\) \b\034\ \024\035\022\013\020\023\035\034 \020\016 \025\032\027\034 \(\240\245)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (3,92, 95% \n\200: )Tj 0.023 Tw T* (1,01\22615,22, p)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,05\).)Tj 0.223 Tw T* (\255\205\r\231\234\211\204\217\200\204: \006\016\024\035\020\034\016 \f\033\ \022\006\016\020\016\020\022\016 PRP \036)Tj /Span<>> BDC ( )Tj EMC (\024\034\005\016\035\037\020\022\022 \024)Tj /Span<>> BDC ( )Tj EMC (\022\024\024\016\005\016\020\022\016\006 \203\r\212 \024)Tj /Span<>> BDC ( )Tj EMC (\034\035\021\033\032\035\032\006 \024\f\034\024\034\025\034\006 \036\016\ \b\016\020\022\030 )Tj -0.001 Tw T* (\033\037\020\032)Tj /Span<>> BDC ( )Tj EMC (\227 \220\017\017\016\021\035\022\036\020\032\004 \022)Tj /Span<>> BDC ( )Tj EMC [(\025\016\031\034\f\037\024\020\032\004 \006\016\035\034\b )0.5(\027\016\005\016\020\022\030 )0.5(\002\033\034\020\022\005\016\024\021\034\013\034 \036\034\024\f\037\027\016\ \020\022\030 \203\r\212. \036\022\b\023 \036\032\033\037\201\016\020\020\ \034\004 \013\016\035\016)]TJ 0 Tw (-)Tj 0.154 Tw T* (\033\034\013\016\020\020\034\024\035\022 \037\020\037\027\022\031\022\033\ \023\016\006\032\002 \b\037\020\020\032\002, \037)Tj /Span<>> BDC ( )Tj EMC (\035\037\021\201\016 \020\022\031\021\034\013\034 \021\037\005\016\024\035\ \036\037 \036\021\027\026\005\016\020\020\032\002 \036)Tj /Span<>> BDC ( )Tj EMC (\006\016\035\037\037\020\037\027\022\031 \022\024\024\027\016\b\034\036\037\ \020\022\004, )Tj 0.089 Tw 0 -1.111 TD [(\020\016\034\025\002\034\b\022\006\034 )0.5(\034\024\035\034\033\034\201\020\034 )0.5(\034\035\020\034\024\022\035\003\024\030 )0.5(\021)]TJ /Span<>> BDC ( )Tj EMC [(\f\034\027\023\005\016\020\020\032\006 )0.6(\033\016\031\023\027\003\035\037\035\037\006. )0.5(\202\033\016\025\023\016\035\024\030 \f\033\034\036\016\b\016\020\022\016\ \b\037\027\003\020\016\004\001\022\002 \024\033\037\036)]TJ 0 Tw (-)Tj 0.023 Tw 0 -1.111 TD (\020\022\035\016\027\003\020\032\002 \033\037\020\b\034\006\022\031\022\033\ \034\036\037\020\020\032\002 \022\024\024\027\016\b\034\036\037\020\022\004\ \036\034 \022\031\025\016\201\037\020\022\016 \034\001\022\025\034\005\020\ \032\002 \036\032\036\034\b\034\036.)Tj /T1_2 1 Tf 0.01 Tc 0.054 Tw 8 0 0 8 70.906 169.3796 Tm [(\037\033\016\r\030\025\f\030)5( \026\033\036\025\021:)]TJ /T1_0 1 Tf 0 Tc 0.059 Tw 8.529 0 Td ( \220\f\022\035\016\027\022\037\027\003\020\032\004 \021\034\f\005\022\021\ \034\036\032\004 \002\034\b, \203\r\212, \f\022\027\034\020\022\b\037\027\ \003\020\037\030 \025\034\027\016\031\020\003, \f\022\027\034\020\022\b\037\ \027\003\020\037\030 \021\022\024\035\037, \f\022\027\034\020\022\b\037\027\ \003\020\032\004 \024\022\020\023\024, \037\023\035\034)Tj 0 Tw (-)Tj 0.023 Tw -8.534 -1.2 Td (\f\027\037\031\006\037, \034\025\034\013\037\235\016\020\020\037\030 \035\ \033\034\006\025\034\007\022\035\037\006\022, \037\023\035\034\f\027\037\ \031\006\037\013\016\027\003, \025\034\013\037\035\032\004 \035\033\034\006\ \025\034\007\022\035\037\006\022, PRP)Tj /T1_2 1 Tf 0.01 Tc 0.018 Tw 0.005 -1.909 Td [(\037\036\035\034\033\032\037\031)5( \032\035\031\030\027\030\026\036\025:)]TJ /T1_0 1 Tf 0 Tc 0.023 Tw 10.401 0 Td ( \037\036\035\034\033\032 \031\037\030\036\027\030\026\035 \034\025 \034\ \035\024\023\035\024\035\036\022\022 \021\034\020\017\027\022\021\035\037\ \022\020\035\016\033\016\024\034\036)Tj /T1_2 1 Tf 0.016 Tc -0.04 Tw -10.401 -2.617 Td [(\024\033\023)5.4( \022\032\031\032\027\036\025\021\035\032\023:)]TJ /T1_3 1 Tf 0.006 Tc -0.035 Tw 8.851 0 Td ( \207\030\026\020\017\027\026)Tj /Span<>> BDC ( )Tj EMC (\202.\224., \216\030\033\022\017\027)Tj /Span<>> BDC ( )Tj EMC (\217.\222., \202\027\024\f\024\r)Tj /Span<>> BDC ( )Tj EMC (\236.\224., \230\017\021\024\r)Tj /Span<>> BDC ( )Tj EMC [(\202.\222. \204\036\f\021\027\024\036 \023\030\017\n\036\027\036\027\017\ \036 \026\031\021\024\023\035\026\n\t, \024\002\024\020\026\013\036\027\ \027\024\005 \021\030\024\n\002\024\006\017\021\026\n\017,)6( )]TJ 0.001 Tc -8.856 -1.2 Td [(\022\026\022 \f\023\024\f\024\002 \031\035\031\004\001\036\027\017\016 \030\ \036\031\035\034\021\026\021\024\r \024\023\036\030\026\021\017\r\027\024\ \020\024 \035\036\004\036\027\017\016 \b\030\024\027\017\004\036\f\022\024\ \020\024 \r\024\f\023\026\035\036\027\017\016 \220\023\017\021\036\035\017\ \026\035\034\027\024\020\024 \022\024\023\004\017\022\024\r\024\020\024 \ \b\024\007\026 \(\f\017\f\021\036\n\026\021\017\004\036\f\022\017\005)1( )]TJ -0.002 Tc -0.039 Tw 0 -1.2 TD (\024\002\024\030 \035\017\021\036\030\026\021\031\030\t \017)Tj /Span<>> BDC ( )Tj EMC (\n\036\021\026\026\027\026\035\017\). )Tj /T1_0 1 Tf 0.002 Tw (\r\034\027\034\f\033\034\021\035\034\027\034\013\022\030.)Tj /T1_3 1 Tf -0.039 Tw ( 2025; \021.)Tj /Span<>> BDC ( )Tj EMC (24, \223)Tj /Span<>> BDC ( )Tj EMC (4, \f.)Tj /Span<>> BDC ( )Tj EMC (138\226151. https://doi.org/10.33878/2073-7556-2025-24-4-138-151)Tj ET 1 0.68 0 0.12 k /GS0 gs q 1 0 0 1 70.8661 523.1533 cm 0 0 m 0 0 l 0 -11.339 l 42.52 -11.339 l 42.52 0 l h f Q BT 0 0 0 0 k /T1_2 1 Tf 0 Tc 0 Tw 9 0 0 9 76.0071 514.226 Tm (\027\030\013\016\n\030)Tj 1 0.68 0 0.12 k /T1_1 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\007\003\032)50(\n\n\217\n)-21(\035\030\002)]TJ 53.418 0 Td [(MET)30(A)-41(-)-41.9(ANAL)30(Y)30(SIS)]TJ -53.418 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 2)69(4, \023\0224, 202)23(5)]TJ 43.013 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 2)69(4, \023\0224, 202)23(5)]TJ /T1_4 1 Tf 25 0 0 25 20.7776 56.0378 Tm (138)Tj ET q 0 g 0 G 0 j 0 J /Fm1 Do Q 0 0 0 0 k 396.85 725.67 59.155 11.338 re f /PlacedPDF /MC0 BDC q 397.481 736.808 m 397.242 736.808 397.049 736.616 397.049 736.376 c 397.049 736.376 l 397.049 726.285 l 397.049 726.045 397.242 725.853 397.481 725.853 c 397.481 725.853 l 455.382 725.853 l 455.62 725.853 455.815 726.045 455.815 726.285 c 455.815 726.285 l 455.815 736.376 l 455.815 736.616 455.62 736.808 455.382 736.808 c 455.382 736.808 l h W n q 0 g -0.0000005 -10.9560913 -10.9560913 0.0000005 426.4320445 736.8086309 cm BX /Sh0 sh EX Q Q q 396.85 725.67 59.155 11.337 re W n 0 0 0 0.84 k q 1 0 0 1 413.5634 732.4249 cm 0 0 m -0.025 0.1 -0.063 0.196 -0.112 0.287 c -0.157 0.374 -0.218 0.451 -0.292 0.515 c -0.37 0.582 -0.46 0.632 -0.558 0.664 c -0.669 0.701 -0.786 0.719 -0.903 0.717 c -1.076 0.722 -1.247 0.681 -1.4 0.6 c -1.536 0.526 -1.652 0.42 -1.74 0.292 c -1.83 0.158 -1.895 0.008 -1.934 -0.149 c -2.018 -0.48 -2.018 -0.827 -1.934 -1.158 c -1.896 -1.316 -1.83 -1.466 -1.74 -1.602 c -1.653 -1.731 -1.536 -1.837 -1.4 -1.912 c -1.247 -1.993 -1.076 -2.033 -0.903 -2.029 c -0.774 -2.032 -0.647 -2.006 -0.528 -1.955 c -0.427 -1.906 -0.337 -1.837 -0.263 -1.753 c -0.185 -1.665 -0.124 -1.563 -0.082 -1.453 c -0.034 -1.338 0 -1.218 0.019 -1.094 c 0.635 -1.094 l 0.624 -1.297 0.578 -1.497 0.497 -1.684 c 0.421 -1.857 0.312 -2.015 0.175 -2.146 c 0.039 -2.277 -0.123 -2.379 -0.3 -2.446 c -0.492 -2.519 -0.695 -2.555 -0.9 -2.552 c -1.15 -2.557 -1.397 -2.506 -1.625 -2.404 c -1.829 -2.307 -2.01 -2.169 -2.157 -1.997 c -2.308 -1.821 -2.423 -1.617 -2.497 -1.397 c -2.655 -0.924 -2.655 -0.412 -2.497 0.061 c -2.423 0.281 -2.307 0.485 -2.157 0.661 c -2.01 0.833 -1.829 0.973 -1.625 1.07 c -1.398 1.174 -1.15 1.226 -0.9 1.222 c -0.707 1.223 -0.515 1.196 -0.329 1.14 c -0.159 1.088 0.001 1.006 0.144 0.898 c 0.278 0.793 0.39 0.662 0.473 0.513 c 0.562 0.349 0.615 0.167 0.629 -0.019 c 0 -0.019 l 0 0 l f Q q 1 0 0 1 414.6923 733.5723 cm 0 0 m 0.584 0 l 0.584 -1.328 l 0.662 -1.204 0.771 -1.103 0.9 -1.033 c 1.046 -0.951 1.213 -0.91 1.381 -0.914 c 1.627 -0.9 1.869 -0.979 2.058 -1.137 c 2.234 -1.312 2.325 -1.556 2.305 -1.803 c 2.305 -3.596 l 1.716 -3.596 l 1.716 -1.976 l 1.724 -1.817 1.678 -1.66 1.585 -1.53 c 1.486 -1.43 1.347 -1.379 1.206 -1.392 c 1.114 -1.39 1.024 -1.408 0.94 -1.445 c 0.865 -1.479 0.798 -1.529 0.744 -1.591 c 0.687 -1.656 0.645 -1.73 0.616 -1.812 c 0.586 -1.896 0.571 -1.986 0.571 -2.077 c 0.571 -3.615 l 0 -3.615 l 0 0 l f Q q 1 0 0 1 418.0385 731.1235 cm 0 0 m 0 -0.099 0.014 -0.198 0.043 -0.292 c 0.069 -0.382 0.112 -0.466 0.17 -0.54 c 0.229 -0.611 0.304 -0.669 0.388 -0.709 c 0.486 -0.754 0.594 -0.776 0.702 -0.773 c 0.845 -0.78 0.987 -0.742 1.108 -0.664 c 1.217 -0.582 1.296 -0.468 1.336 -0.337 c 1.881 -0.337 l 1.827 -0.603 1.675 -0.838 1.456 -0.996 c 1.35 -1.073 1.231 -1.131 1.105 -1.169 c 0.971 -1.208 0.831 -1.229 0.691 -1.227 c 0.509 -1.227 0.328 -1.191 0.16 -1.121 c 0.007 -1.063 -0.13 -0.972 -0.244 -0.855 c -0.356 -0.73 -0.44 -0.583 -0.491 -0.422 c -0.548 -0.243 -0.576 -0.056 -0.574 0.133 c -0.575 0.313 -0.545 0.493 -0.486 0.664 c -0.426 0.826 -0.335 0.974 -0.22 1.102 c 0.004 1.375 0.338 1.534 0.691 1.535 c 0.883 1.539 1.072 1.495 1.243 1.408 c 1.402 1.326 1.541 1.209 1.649 1.067 c 1.759 0.922 1.838 0.757 1.883 0.582 c 1.932 0.396 1.945 0.203 1.92 0.013 c 0 0.013 l 0 0 l 1.342 0.377 m 1.335 0.468 1.315 0.557 1.283 0.643 c 1.253 0.724 1.209 0.798 1.153 0.863 c 1.097 0.922 1.03 0.97 0.957 1.004 c 0.874 1.043 0.783 1.063 0.691 1.062 c 0.6 1.062 0.509 1.044 0.425 1.009 c 0.345 0.976 0.273 0.926 0.213 0.863 c 0.153 0.799 0.105 0.724 0.072 0.643 c 0.037 0.559 0.017 0.468 0.014 0.377 c 1.355 0.377 l h f Q q 1 0 0 1 422.1581 731.7051 cm 0 0 m -0.012 0.144 -0.082 0.276 -0.194 0.366 c -0.31 0.452 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Semi-super)-31.9(v)-16(ised lear)-15(ning t)17(o)]TJ /Span<>> BDC ( )Tj EMC [(im)10(p)25(r)-32(ove gener)-32.9(al)-31(izabil)-31(i)-24(t)-9.9(y )]TJ 0.023 Tw -1.796 -1.25 Td (of)Tj /Span<>> BDC ( )Tj EMC [(r)-37(isk p)25(r)-24(edic)-16(t)-32(ion models. )]TJ /T1_2 1 Tf [(J Biomed Infor)-13.9(m)]TJ /T1_1 1 Tf (. 2019;92:103117.)Tj 0.072 Tw T* (19.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(K)25(ud)-16(o)]TJ /Span<>> BDC ( )Tj EMC [(SE, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Ar)-22(t)-32(if)-27.9(ic)-24(ial Intell)-31(igence Sy)-13(stem t)17(o)]TJ /Span<>> BDC ( )Tj EMC [(De)-12(ter)-16(mine R)-24(isk )]TJ 0.054 Tw -1.796 -1.25 Td (of)Tj /Span<>> BDC ( )Tj EMC [(T1 Col)30(or)-24(ec)-16(t)15(al Cancer Me)-12(t)15.1(ast)15(asis t)17(o)]TJ /Span<>> BDC ( )Tj EMC [(L)70(ym)10(ph N)-14(ode. )]TJ /T1_2 1 Tf 0 Tw (Gastroenterology.)Tj /T1_1 1 Tf ( )Tj T* (2021;160\(4\):1075\2261084.e2.)Tj 0.187 Tw T* (20.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(W)12(ang)]TJ /Span<>> BDC ( )Tj EMC [(X, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Devel)30(opment and v)-14.9(al)-31(id)42(a)15(t)-32(ion of)]TJ /Span<>> BDC ( )Tj EMC [(ar)-22(t)-32(if)-27.9(ic)-24(ial intel)]TJ 0 Tw (-)Tj 0.208 Tw -1.796 -1.25 Td [(l)-31(igence models for p)25(r)-24(eoper)-33(a)15(t)-32(i)-15.9(ve p)25(r)-23.9(edic)-16(t)-32(ion of)]TJ /Span<>> BDC ( )Tj EMC [(infer)-36.9(ior mesenter)-37(ic )]TJ 0.072 Tw T* [(ar)-22(ter)-23.9(y )0.5(l)35(ym)10(ph )0.6(nodes )0.5(me)-12(t)15(ast)15.1(asis )0.5(in )0.6(lef)-28(t )0.5(col)30(on )0.5(and )0.5(r)-23.9(ec)-16(t)15(al )0.5(cancer. )]TJ /T1_2 1 Tf 25.607 0 Td [(Eur )0.6(J )]TJ 0.023 Tw -25.607 -1.25 Td (Surg Oncol.)Tj /T1_1 1 Tf ( 2022;48\(12\):2475\2262486.)Tj 0.003 Tw T* (21.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Han)Tj /Span<>> BDC ( )Tj EMC [(T. e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Appl)-31(ica)15(t)-32(ion of)]TJ /Span<>> BDC ( )Tj EMC [(ar)-21.9(t)-32(if)-28(ic)-24(ial intell)-30.9(igence in a)]TJ /Span<>> BDC ( )Tj EMC [(r)-24(eal-w)-14(or)-30(ld )]TJ 0.112 Tw -1.796 -1.25 Td [(r)-24(esear)-31.9(ch for p)25(r)-23.9(edic)-16(t)-32(ing t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(r)-37(isk of)]TJ /Span<>> BDC ( )Tj EMC [(l)-31(i)-16(ver me)-12(t)15.1(ast)15(asis in T1 col)30(or)-23.9(ec)-16(t)15(al )]TJ 0 Tw T* (cancer. )Tj /T1_2 1 Tf 0.023 Tw 3.19 0 Td (Cancer Cell Int.)Tj /T1_1 1 Tf ( 2022;22\(1\):28.)Tj 0.008 Tc 0.35 Tw -3.19 -1.25 Td (22.)Tj /Span<>> BDC ( )Tj EMC 1.828 0 Td [(K)-16(asai, )0.6(S, )0.5(e)-12(t)]TJ /Span<>> BDC ( )Tj EMC 5.643 0 Td [(al. )0.6(T)46.9(he)]TJ /Span<>> BDC ( )Tj EMC 3.647 0 Td [(Ef)-56(fec)-16(t)-32(i)-15.9(veness )0.5(of)]TJ /Span<>> BDC ( )Tj EMC 7.559 0 Td [(Ma)-17(chine )0.5(L)35.1(ear)-14.9(ning )0.5(in)8( )]TJ 0 Tc 0.022 Tw -18.677 -1.25 Td [(P)35(r)-24(edic)-15.9(t)-32(ing L)-32(a)15(ter)-33(al L)70(ym)10(ph N)-14(ode Me)-12(t)15(ast)15.1(asis F)10(r)-32(om L)35(o)-14(wer R)13(ec)-16(t)15(al Cancer: )]TJ -0.001 Tw T* (A)Tj /Span<>> BDC ( )Tj EMC [(S)-16(ingle Center Devel)30.1(opment and V)25(al)-31(id)42(a)15(t)-31.9(ion S)14.9(tud)17.1(y. )]TJ /T1_2 1 Tf (Ann Gastroenterol )Tj 0 Tw T* (Surg.)Tj /T1_1 1 Tf 0.023 Tw ( 2022;6\(1\):92\226100.)Tj 0.267 Tw T* (23.)Tj /Span<>> BDC ( )Tj EMC (Masum)Tj /Span<>> BDC ( )Tj EMC [(S, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Da)15(t)15(a anal)35(y)-16(t)-32(ics and ar)-22(t)-32(if)-28(ic)-23.9(ial intell)-30.9(igence in )]TJ 0.067 Tw T* [(p)25(r)-24(edic)-15.9(t)-32(ing leng)17(t)-13(h of)]TJ /Span<>> BDC ( )Tj EMC [(st)15(a)15(y, r)-24(eadmission, and mor)-22(t)15(al)-31(i)-23.9(t)-10(y: a)]TJ /Span<>> BDC ( )Tj EMC [(popul)-15.9(a)15(t)-32(ion-)]TJ 0.233 Tw T* [(based stud)17.1(y of)]TJ /Span<>> BDC ( )Tj EMC [(sur)-32(gical mana)-17(gement of)]TJ /Span<>> BDC ( )Tj EMC [(col)30.1(or)-24(ec)-16(t)15(al cancer. )]TJ /T1_2 1 Tf 0 Tw (Discov )Tj T* (Oncol.)Tj /T1_1 1 Tf 0.023 Tw ( 2022;13\(1\):11.)Tj 0.303 Tw T* (24.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(W)20(o\270nia)-17(ck, A, K)25(si\271\272ek)]TJ /Span<>> BDC ( )Tj EMC [(W, Mr)-32(o)-14(wczyk)]TJ /Span<>> BDC ( )Tj EMC (P. A)Tj /Span<>> BDC ( )Tj EMC [(N)-14(ovel App)25(r)-32(oa)-17(ch for )]TJ 0.064 Tw -1.796 -1.25 Td [(P)35(r)-24(edic)-15.9(t)-32(ing t)-12.9(he)]TJ /Span<>> BDC ( )Tj EMC [(Sur)-31.9(v)-16(i)-16(v)-15(al )0.5(of)]TJ /Span<>> BDC ( )Tj EMC 10.812 0 Td [(Col)30(or)-24(ec)-15.9(t)15(al Cancer P)40(a)15.1(t)-32(ients )0.5(Using )0.5(Ma)-17(chine )]TJ -0.032 Tw -10.812 -1.25 Td [(L)35(ear)-15(ning T)40(echniques and A)15(d)-16.9(v)-15(anced P)40(ar)-32.9(ame)-12(ter Opt)-32(imiza)15.1(t)-32(ion Me)-11.9(t)-13(hods. )]TJ /T1_2 1 Tf 0.023 Tw T* (Cancers \(Basel\).)Tj /T1_1 1 Tf ( 2024. 16\(18\).)Tj 0.014 Tc 0.505 Tw T* (25.)Tj /Span<>> BDC ( )Tj EMC 1.851 0 Td [(Ol)-30.7(i)-15.8(veir)-32.8(a)]TJ /Span<>> BDC ( )Tj EMC [(T, e)-11.7(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Sur)-31.7(v)-15.8(i)-15.7(v)-14.8(abil)-30.7(i)-23.8(t)-9.7(y P)35.2(r)-23.7(edic)-15.8(t)-31.7(ion of)]TJ /Span<>> BDC ( )Tj EMC [(Col)30.2(or)-23.7(ec)-15.7(t)15.2(al)14.1( )]TJ 0 Tc 0.218 Tw -1.851 -1.25 Td [(Cancer P)40(a)15(t)-32(ients: A)]TJ /Span<>> BDC ( )Tj EMC [(Sy)-13(stem wi)-24(t)-13(h Evol)30(v)-15.9(ing F)10(ea)15(tur)-24(es for Cont)-32(inuous )]TJ 0 Tw T* [(Im)10(p)25(r)-32(ovement. )]TJ /T1_2 1 Tf 0.023 Tw 5.931 0 Td (Sensors \(Basel\).)Tj /T1_1 1 Tf ( 2018; 18\(9\).)Tj 0.002 Tw -5.931 -1.25 Td (26.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Qiu, B, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Appl)-31(ica)15.1(t)-32(ion of)]TJ /Span<>> BDC ( )Tj EMC [(ma)-17(chine lear)-15(ning techniques in r)-23.9(eal-)]TJ -0.004 Tw -1.796 -1.25 Td [(w)-14(or)-30(ld r)-24(esear)-32(ch t)17(o)]TJ /Span<>> BDC ( )Tj EMC [(p)25(r)-24(edic)-16(t t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(r)-37(isk of)]TJ /Span<>> BDC ( )Tj EMC [(l)-31(i)-16(ver me)-12(t)15(ast)15(asis in r)-23.9(ec)-16(t)15(al cancer. )]TJ /T1_2 1 Tf 0.023 Tw T* [(F)27(ront Oncol.)]TJ /T1_1 1 Tf ( 2022;12:1065468.)Tj -0.003 Tw T* (27.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(L)-32(iu)]TJ /Span<>> BDC ( )Tj EMC [(Y, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Ut)-32(il)-30.9(izing ma)-17(chine lear)-14.9(ning al)16(gor)-36.9(i)-24(t)-13(hms for p)25(r)-24(edic)-16(t)-32(ing )]TJ 0.177 Tw -1.796 -1.25 Td [(r)-37(isk f)16(a)-17(c)-16(t)17(or)-9.9(s for bone me)-12(t)15(ast)15(asis fr)-32(om r)-37(ight-sided col)30(on car)-32(c)-24(inoma )]TJ 0.183 Tw T* [(af)-28(ter com)10(ple)-12(te meso)-16(col)-31(ic e)-18(x)-13(c)-23.9(ision: a)]TJ /Span<>> BDC ( )Tj EMC [(10-year r)-24(e)-12(tr)-32(ospec)-16(t)-31.9(i)-16(ve mul)56.1(t)-32(i)]TJ 0 Tw (-)Tj 0.023 Tw T* [(center stud)17.1(y. )]TJ /T1_2 1 Tf (Discov Oncol.)Tj /T1_1 1 Tf ( 2024;15\(1\):463.)Tj 0.004 Tc 0.35 Tw T* (28.)Tj /Span<>> BDC ( )Tj EMC 1.813 0 Td [(L)-32.2(i)]TJ /Span<>> BDC ( )Tj EMC [(X, e)-12.2(t)]TJ /Span<>> BDC ( )Tj EMC [(al. P)34.8(r)-24.1(eoper)-33.2(a)14.8(t)-32.1(i)-16.2(ve Albumin t)16.8(o)]TJ /Span<>> BDC ( )Tj EMC [(Alk)-17.2(al)-31.1(ine Phospha)14.8(t)14.9(ase)4( )]TJ 0 Tc 0.105 Tw -1.813 -1.25 Td [(R)-10(a)15(t)-32(io and Infl)-16(amma)15.1(t)17(or)-24(y Bur)-24(den Inde)-18(x for R)13(ec)-16(t)15(al Cancer P)35(r)-32(o)-16(gnost)-31.9(ic )]TJ 0.292 Tw T* [(N)-14(omo)-16(gr)-32.9(am-Constr)-22(uc)-16(t)-31.9(ion: Based on Mul)56(t)-32(iple Ma)-17(chine L)35(ear)-15(ning. )]TJ /T1_2 1 Tf 0 Tw (J )Tj 0.023 Tw T* [(Inf)-22(lamm R)21(es.)]TJ /T1_1 1 Tf ( 2024;17:11161\22611174.)Tj 0.337 Tw 29.055 62.5 Td (29.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Qiu)Tj /Span<>> BDC ( )Tj EMC [(B, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC (al. A)Tj /Span<>> BDC ( )Tj EMC [(ma)-17(chine lear)-15(ning-based model for p)25(r)-24(edic)-16(t)]TJ 0 Tw (-)Tj 0.163 Tw -1.796 -1.25 Td [(ing )0.5(dist)15.1(ant )0.5(me)-12(t)15(ast)15.1(asis )0.5(in )0.5(p)32(a)15(t)-31.9(ients )0.5(wi)-24(t)-12.9(h )0.5(r)-24(ec)-16(t)15.1(al )0.5(cancer. )]TJ /T1_2 1 Tf 22.721 0 Td [(F)27(ront )0.5(Oncol.)]TJ /T1_1 1 Tf 0 Tw ( )Tj -22.721 -1.25 Td (2023;13:1235121.)Tj 0.046 Tw T* (30.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Xing)Tj /Span<>> BDC ( )Tj EMC [(Y, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Devel)30.1(opment of)]TJ /Span<>> BDC ( )Tj EMC [(p)25(r)-24(edic)-16(t)-32(ion models for l)-30.9(i)-16(ver me)-12(t)15(as)]TJ 0 Tw (-)Tj 0.07 Tw -1.796 -1.25 Td [(t)15(asis in col)30.1(or)-24(ec)-16(t)15(al cancer based on ma)-17(chine lear)-15(ning: a)]TJ /Span<>> BDC ( )Tj EMC [(popul)-16(a)15(t)-31.9(ion-)]TJ 0.023 Tw T* [(level stud)17(y. )]TJ /T1_2 1 Tf [(T)56(ransl Cancer R)21(es.)]TJ /T1_1 1 Tf ( 2024;13\(11\):5943\2265952.)Tj 0.324 Tw T* (31.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Zhao)Tj /Span<>> BDC ( )Tj EMC [(B, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Using ma)-17(chine lear)-15(ning t)17(o)]TJ /Span<>> BDC ( )Tj EMC [(constr)-22(uc)-16(t nomo)]TJ 0 Tw (-)Tj 0.296 Tw -1.796 -1.25 Td [(gr)-33(ams for p)32(a)15(t)-32(ients wi)-23.9(t)-13(h me)-12(t)15(ast)15(a)15(t)-32(ic col)30(on cancer. )]TJ /T1_2 1 Tf (Colorectal Dis.)Tj /T1_1 1 Tf 0 Tw ( )Tj T* (2020;22\(8\):914\226922.)Tj 0.198 Tw T* (32.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Or)-33(af)16(aie)]TJ /Span<>> BDC ( )Tj EMC [(A, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. T)47(he)]TJ /Span<>> BDC ( )Tj EMC [(asso)-16(c)-24(ia)15.1(t)-32(ion of)]TJ /Span<>> BDC ( )Tj EMC [(p)24.9(r)-23.9(eoper)-33(a)15(t)-32(i)-16(ve hema)15(t)17.1(ol)30(o)-16(gic )]TJ -0.013 Tw -1.796 -1.25 Td [(p)32(ar)-33(ame)-12(ter)-9.9(s wi)-24(t)-12.9(h shor)-22(t-ter)-15.9(m cl)-31(inical )0.5(outcomes in r)-23.9(ec)-16(t)15(al cancer: )0.5(A)]TJ /Span<>> BDC ( )Tj EMC (fea)Tj 0 Tw (-)Tj 0.023 Tw T* [(tur)-23.9(e im)10(por)-22(t)15(ance anal)35(y)-12.9(sis. )]TJ /T1_2 1 Tf (Cancer Med)Tj /T1_1 1 Tf (. 2024;13\(10\):e7225.)Tj 0.083 Tw T* (33.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(T)35(ian)]TJ /Span<>> BDC ( )Tj EMC [(Y, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Sp)32(a)15(t)-32(iall)35.1(y v)-15(ar)-24(ying ef)-56(fec)-15.9(ts of)]TJ /Span<>> BDC ( )Tj EMC [(p)25(r)-24(edic)-16(t)17(or)-9.9(s for t)-13(he)]TJ /Span<>> BDC ( )Tj EMC (sur)Tj 0 Tw 25.49 0 Td (-)Tj 0.259 Tw -27.286 -1.25 Td [(v)-16(i)-16(v)-14.9(al p)25(r)-24(edic)-16(t)-32(ion of)]TJ /Span<>> BDC ( )Tj EMC [(nonme)-12(t)15.1(ast)15(a)15(t)-32(ic col)30(or)-24(ec)-16(t)15(al Cancer. )]TJ /T1_2 1 Tf (BMC Cancer)Tj /T1_1 1 Tf 0 Tw (. )Tj T* (2018;18\(1\):1084.)Tj 0.156 Tw T* (34.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(W)22(ei)]TJ /Span<>> BDC ( )Tj EMC [(R, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Constr)-22(uc)-15.9(t)-32(ion and v)-15(al)-31(id)42(a)15(t)-32(ion of)]TJ /Span<>> BDC ( )Tj EMC [(ma)-17(chine lear)-15(ning )]TJ -0.017 Tw -1.796 -1.25 Td [(models )0.5(for )0.5(p)25(r)-24(edic)-15.9(t)-32(ing )0.5(dist)15(ant )0.5(me)-12(t)15(ast)15.1(ases )0.5(in newl)35.1(y dia)-16.9(gnosed )0.5(col)30(or)-24(ec)]TJ 0 Tw (-)Tj -0.004 Tw T* [(t)15(al cancer p)32(a)15(t)-32(ients: A)]TJ /Span<>> BDC ( )Tj EMC [(l)-15.9(ar)-32(ge-scale and r)-24(eal-w)-14(or)-29.9(ld cohor)-22(t stud)17(y. )]TJ /T1_2 1 Tf 0 Tw (Cancer )Tj T* (Med.)Tj /T1_1 1 Tf 0.023 Tw ( 2024;13\(5\):e6971.)Tj 0.173 Tw T* (35.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(L)-32(iu)]TJ /Span<>> BDC ( )Tj EMC [(Y, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Ident)-31.9(if)-28(ica)15(t)-32(ion of)]TJ /Span<>> BDC ( )Tj EMC [(high-r)-37(isk f)16(a)-17(c)-16(t)17.1(or)-10(s for r)-23.9(ecur)-24(r)-24(ence )]TJ 0.171 Tw -1.796 -1.25 Td (of)Tj /Span<>> BDC ( )Tj EMC [(col)30(on cancer foll)30.1(o)-14(wing com)10(ple)-12(te meso)-16(col)-31(ic e)-18(x)-12.9(c)-24(ision: An)]TJ /Span<>> BDC ( )Tj EMC (8-year )Tj 0.023 Tw T* [(r)-24(e)-12(tr)-31.9(ospec)-16(t)-32(i)-16(ve stud)17.1(y. )]TJ /T1_2 1 Tf (PLoS One.)Tj /T1_1 1 Tf ( 2023;18\(8\):e0289621.)Tj 0.249 Tw T* (36.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Ishizak)-15.9(i)]TJ /Span<>> BDC ( )Tj EMC [(T, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. P)35(r)-24(edic)-16(t)-32(i)-15.9(ve modell)-31(ing for high-r)-36.9(isk st)15(a)-17(ge II )]TJ 0.337 Tw -1.796 -1.25 Td [(col)30(on cancer using aut)17(o-ar)-22(t)-31.9(if)-28(ic)-24(ial intell)-30.9(igence. )]TJ /T1_2 1 Tf [(T)54(ech Colop)46.1(roctol.)]TJ /T1_1 1 Tf 0 Tw ( )Tj T* (2023;27\(3\):183\226188.)Tj 0.004 Tc 0.35 Tw T* (37.)Tj /Span<>> BDC ( )Tj EMC 1.812 0 Td [(Bibaul)55.9(t)]TJ /Span<>> BDC ( )Tj EMC 3.476 0 Td [(JE, )0.5(Chang)]TJ /Span<>> BDC ( )Tj EMC 4.793 0 Td [(D)11.9(T, Xing)]TJ /Span<>> BDC ( )Tj EMC [(L. )0.5(Devel)29.9(opment and )0.5(v)-15.1(al)-31.1(id)41.9(a)15(t)-32.1(ion)4( )]TJ 0 Tc 0.054 Tw -10.081 -1.25 Td (of)Tj /Span<>> BDC ( )Tj EMC (a)Tj /Span<>> BDC ( )Tj EMC [(model t)17(o)]TJ /Span<>> BDC ( )Tj EMC [(p)25(r)-24(edic)-15.9(t sur)-31.9(v)-16(i)-16(v)-15(al in col)30(or)-23.9(ec)-16(t)15(al cancer using a)]TJ /Span<>> BDC ( )Tj EMC [(gr)-33(adient-)]TJ 0.023 Tw T* [(bo)-16(osted ma)-16.9(chine. )]TJ /T1_2 1 Tf 0 Tw (Gut)Tj /T1_1 1 Tf 0.023 Tw (. 2021;70\(5\):884\226889.)Tj 0.002 Tc 0.349 Tw T* (38.)Tj /Span<>> BDC ( )Tj EMC 1.803 0 Td [(Amygd)42.3(al)30.3(os)]TJ /Span<>> BDC ( )Tj EMC [(I, e)-11.7(t)]TJ /Span<>> BDC ( )Tj EMC [(al. N)-13.7(ovel ma)-16.7(chine lear)-14.6(ning al)16.3(gor)-36.6(i)-23.7(t)-12.7(hm can)2( )]TJ 0 Tc 0.12 Tw -1.803 -1.25 Td [(ident)-32(if)-33.9(y p)32(a)15(t)-32(ients a)15(t r)-37(isk of)]TJ /Span<>> BDC ( )Tj EMC [(po)-16(or over)-33(all sur)-32(v)-16(i)-15.9(v)-15(al foll)30.1(o)-14(wing cur)-33(a)15(t)-32(i)-16(ve )]TJ 0.195 Tw T* [(r)-24(esec)-15.9(t)-32(ion for col)30.1(or)-24(ec)-16(t)15(al l)-30.9(i)-16(ver me)-12(t)15.1(ast)15(ases. )]TJ /T1_2 1 Tf [(J Hepatobiliar)-42.9(y P)18(ancreat )]TJ 0 Tw T* (Sci.)Tj /T1_1 1 Tf 0.023 Tw ( 2023;30\(5\):602\226614.)Tj 0.101 Tw T* (39.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(P)-24(iao)]TJ /Span<>> BDC ( )Tj EMC (ZH, Ge)Tj /Span<>> BDC ( )Tj EMC [(R, L)35(u)]TJ /Span<>> BDC ( )Tj EMC (L. An)Tj /Span<>> BDC ( )Tj EMC [(ar)-22(t)-32(if)-28(ic)-23.9(ial intell)-31(igence p)25(r)-24(edic)-16(t)-31.9(ion model )]TJ 0.006 Tc 0.349 Tw -1.796 -1.25 Td [(out)0.5(per)-23.6(f)0.5(or)-15.6(ms)0.5( con)0.5(vent)-31.5(ional)0.5( gui)0.5(del)-30.6(i)0.5(nes in p)25.4(r)-23.6(edi)0.5(c)-15.6(t)-31.6(in)0.5(g l)35.4(y)0.5(m)10.4(ph node)6( )]TJ 0 Tc 0.023 Tw T* [(me)-12(t)15(ast)15.1(asis of)]TJ /Span<>> BDC ( )Tj EMC [(T1 col)30(or)-24(ec)-15.9(t)15(al cancer. )]TJ /T1_2 1 Tf [(F)27.1(ront Oncol)]TJ /T1_1 1 Tf (. 2023;13:1229998.)Tj 0.072 Tw T* (40.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Y)50(ang)]TJ /Span<>> BDC ( )Tj EMC [(X, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. P)35(r)-24(edic)-16(t)-32(ing Col)30(or)-24(ec)-15.9(t)15(al Cancer Sur)-32(v)-16(i)-16(v)-14.9(al Using T)35(ime-)]TJ 0.002 Tc 0.35 Tw -1.796 -1.25 Td [(t)16.7(o-Event Ma)-17.3(chine L)34.7(ear)-15.2(ning: R)12.7(e)-12.3(tr)-32.3(ospec)-16.3(t)-32.3(i)-16.3(ve Cohor)-22.3(t S)14.7(tud)16.7(y. )]TJ /T1_2 1 Tf [(J Med)2( )]TJ 0 Tc 0.023 Tw T* [(Inter)-14(net R)21(es.)]TJ /T1_1 1 Tf ( 2023;25:e44417.)Tj 0.19 Tw T* (41.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(M)-24(ohammadi)]TJ /Span<>> BDC ( )Tj EMC [(G, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Cl)-16(assif)-28(ica)15.1(t)-32(ion and Dia)-16.9(gnost)-32(ic P)35(r)-23.9(edic)-16(t)-32(ion )]TJ 0.015 Tc 0.534 Tw -1.796 -1.25 Td (of)Tj /Span<>> BDC ( )Tj EMC [(Col)30.4(or)-23.6(ec)-15.6(t)15.4(al Cancer M)-23.6(or)-21.6(t)15.4(al)-30.6(i)-23.6(t)-9.5(y Based on Ma)-16.6(chine L)35.4(ear)-14.6(ni)0.5(ng)15( )]TJ 0 Tc 0.128 Tw T* [(Al)16(gor)-37(i)-23.9(t)-13(hms: A)]TJ /Span<>> BDC ( )Tj EMC [(Mul)56.1(t)-32(icenter Na)15(t)-32(ional S)15(tud)17(y. )]TJ /T1_2 1 Tf [(Asian P)18(ac J Cancer Prev.)]TJ /T1_1 1 Tf 0 Tw ( )Tj T* (2024;25\(1\):333\226342.)Tj -0.003 Tw T* (42.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Zhang)Tj /Span<>> BDC ( )Tj EMC [(W, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Devel)30(opment and v)-15(al)-31(id)42(a)15(t)-32(ion of)]TJ /Span<>> BDC ( )Tj EMC [(an ar)-22(t)-32(if)-27.9(ic)-24(ial intel)]TJ 0 Tw (-)Tj 0.117 Tw -1.796 -1.25 Td [(l)-31(igence p)25(r)-24(edic)-16(t)-31.9(ion model and a)]TJ /Span<>> BDC ( )Tj EMC [(sur)-32(v)-16(i)-16(v)-14.9(al r)-37(isk str)-32.9(a)14.9(t)-31.9(if)-28(ica)15(t)-32(ion for l)35(ung )]TJ 0.053 Tw T* [(me)-12(t)15(ast)15.1(asis in col)30(or)-24(ec)-16(t)15(al cancer fr)-31.9(om highl)35(y imbal)-16(anced d)42(a)15(t)15(a: A)]TJ /Span<>> BDC ( )Tj EMC (mul)Tj 0 Tw (-)Tj 0.023 Tw T* [(t)-32(icenter r)-24(e)-12(tr)-32(ospec)-15.9(t)-32(i)-16(ve stud)17(y. )]TJ /T1_2 1 Tf (Eur J Surg Oncol.)Tj /T1_1 1 Tf ( 2023;49\(12\):107107.)Tj 0.164 Tw T* (43.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(L)-32(i)]TJ /Span<>> BDC ( )Tj EMC [(J, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC (al. An)Tj /Span<>> BDC ( )Tj EMC [(inter)-23.9(p)24.9(r)-23.9(e)-12(t)15(able deep lear)-15(ning fr)-33(amew)-13.9(or)-24(k for p)25(r)-24(e)]TJ 0 Tw (-)Tj 0.077 Tw -1.796 -1.25 Td [(dic)-16(t)-32(ing l)-31(i)-15.9(ver me)-11.9(t)15(ast)15(ases in post)17.1(oper)-33(a)15(t)-32(i)-16(ve col)30(or)-24(ec)-15.9(t)15(al cancer p)32(a)15(t)-32(ients )]TJ 0.259 Tw T* [(using na)15(tur)-33(al l)-15.9(angua)-17(ge p)25(r)-31.9(o)-16(cessing and cl)-30.9(inical d)42(a)15(t)15(a integr)-32.9(a)15(t)-32(ion. )]TJ /T1_2 1 Tf 0.023 Tw T* (Cancer Med.)Tj /T1_1 1 Tf ( 2023;12\(18\):19337\22619351.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 0 Tw 7.5 0 0 7.5 42.5197 759.8869 Tm [(\007\003\032)50(\n\n\217\n)-21(\035\030\002)]TJ 53.418 0 Td [(MET)30(A)-41(-)-41.9(ANAL)30(Y)30(SIS)]TJ /T1_3 1 Tf 25 0 0 25 505.5395 56.0378 Tm (137)Tj ET endstream endobj 1488 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.109 Tw 10 0 0 10 70.8661 724.8299 Tm [(A)17(UC, \024\007\027\026\022\024 \031\007\026\035\036\027\017\036 \024\007\027\ \024\020\024 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC [(\017\f\f\035\036\007\024\r\026\027\017\005 )0.5(\023\030\017)]TJ 0 Tw (-)Tj 0.278 Tw 0 -1.218 TD (\r\036\035\024 \022)Tj /Span<>> BDC ( )Tj EMC 3.398 0 Td [(\f\027\017\032\036\027\017\033 )0.5(\024\002\255\036\007\017\027\201\027\027\024\005 )0.5(\024\006\036\027\022\017 \017)]TJ /Span<>> BDC ( )Tj EMC 15.808 0 Td (\031\030\024\r\027\016 )Tj 0.146 Tw -19.206 -1.218 Td [(\020\036\021\036\030\024\020\036\027\027\024\f\021\017, )0.6(\004\021\024 )0.5(\031\022\026\t\r\026\036\021 )0.5(\027\026)]TJ /Span<>> BDC ( )Tj EMC 14.599 0 Td [(\036\020\024 )0.5(\027\026\004\017\021\036\035\034\027\t\005 )]TJ 0.051 Tw -14.599 -1.218 Td (\r\022\035\026\007 \r)Tj /Span<>> BDC ( )Tj EMC (\024\002\013\031\033 \r\026\030\017\026\002\036\035\034\027\024\f\021\034\ . \225\021\024 \n\024\032\036\021 \002\t\021\034 \f\r\016)Tj 0 Tw (-)Tj 0.049 Tw T* (\026\027\024 \f)Tj /Span<>> BDC ( )Tj EMC (\r\t\f\024\022\017\n \022\026\004\036\f\021\r\024\n \n\024\007\036\035\017\ \017)Tj /Span<>> BDC ( )Tj EMC (\024\023\021\017\n\017\017\030\024\r\026\027)Tj 0 Tw (-)Tj 0.034 Tw T* (\027\024\005 \027\026\f\021\030\024\005\022\024\005 \023\026\030\026\n\036\ \021\030\024\r \r)Tj /Span<>> BDC ( )Tj EMC (\007\026\027\027\024\n \017\f\f\035\036\007\024\r\026\027\017\017. )Tj -0.001 Tw 0 -1.218 TD [(\212\024\023\024\035\027\017\021\036\035\034\027\t\n )0.5(\024\020\030\026\027\017\004\036\027\017\036\n \n\024\032\036\021 \002\t\ \021\034 \023\024\021\036\027\006\017)]TJ 0 Tw (-)Tj -0.002 Tw 0 -1.218 TD (\026\035\034\027\024\036 \027\026\035\017\004\017\036 \023\031\002\035\017\ \022\026\006\017\024\027\027\024\020\024 \f\n\036\013\036\027\017\016, \024\ \006\036\027\036\027)Tj 0 Tw (-)Tj 0.186 Tw T* (\027\024\036 \f)Tj /Span<>> BDC ( )Tj EMC [(\023\024\n\024\013\034\033 funnel pl)30(o)17(t. \211\n\036\030\036\027\027\026\016 \026\f\017\n\n\036\021\030\017\016\ )]TJ 0.21 Tw T* (\020\030\026\235\017\022\026 \031\022\026\t\r\026\036\021 \027\026)Tj /Span<>> BDC ( )Tj EMC (\r\024\n\024\032\027\031\033 \017\002\017\030\026\021\036\035\034\027\024\ \f\021\034 )Tj 0.391 Tw T* (\023\031\002\035\017\022\026\006\017\017 \017\f\f\035\036\007\024\r\026\027\ \017\005 \f)Tj /Span<>> BDC ( )Tj EMC (\023\024\035\024\032\017\021\036\035\034\027\t\n\017 \030\036)Tj 0 Tw (-)Tj 0.106 Tw T* (\031\035\034\021\026\021\026\n\017, \004\021\024 \021\026\022\032\036 \n\ \024\032\036\021 \017\f\022\026\032\026\021\034 \026\020\030\036\020\017\ \030\024\r\026\027)Tj 0 Tw (-)Tj 0 -1.218 TD (\027\t\036 \024\006\036\027\022\017.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 70.936 542.1598 Tm [(\020)21(\026\027\r\241\224\034\022\031\034)]TJ 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0 Tc 0.124 Tw 10 0 0 10 70.8661 517.8038 Tm (\224\024\r\030\036\n\036\027\027\t\036 \017\f\f\035\036\007\024\r\026\027\ \017\016 \r\f\201 \004\026\013\036 \023\024\007\004\201\030\022\017\r\026\ \033\021 )Tj 0.34 Tw 0 -1.218 TD (\027\036\024\002\b\024\007\017\n\024\f\021\034 \017\027\021\036\020\030\026\ \006\017\017 \026\035\020\024\030\017\021\n\024\r \n\026\001\017\027\027\ \024\020\024 )Tj 0.182 Tw T* (\024\002\031\004\036\027\017\016 \r)Tj /Span<>> BDC ( )Tj EMC (\022\035\017\027\017\004\036\f\022\031\033 \023\030\026\022\021\017\022\031\ , \004\021\024 \f\023\024\f\024\002\f\021\r\031)Tj 0 Tw (-)Tj 0.122 Tw T* (\036\021 \023\024\r\t\001\036\027\017\033 \021\024\004\027\024\f\021\017\ \023\030\024\020\027\024\017\030\024\r\026\027\017\016 \030\036\006\017\ \007\017\r\026 )Tj 0.004 Tw T* (\022\024\035\024\030\036\022\021\026\035\034\027\024\020\024 \030\026\022\ \026 \017)Tj /Span<>> BDC ( )Tj EMC (\030\026\030\026\002\024\021\022\036 \002\024\035\036\036 \220\235\235\036\ \022\021\017\r)Tj 0 Tw (-)Tj 0.253 Tw T* (\027\t\b \023\036\030\f\024\027\026\035\017\017\030\024\r\026\027\027\t\ \b \f\021\030\026\021\036\020\017\005 \035\036\004\036\027\017\016. \212\ \035\016 )Tj 0.118 Tw T* (\023\024\r\t\001\036\027\017\016 \r\024\f\023\030\024\017\r\024\007\017\ \n\024\f\021\017 \017)Tj /Span<>> BDC ( )Tj EMC (\022\035\017\027\017\004\036\f\022\024\005 \023\030\017)Tj 0 Tw (-)Tj -0.037 Tw T* (\n\036\027\017\n\024\f\021\017 \n\024\007\036\035\036\005 \027\036\024\002\ \b\024\007\017\n\026 \f\021\026\027\007\026\030\021\017\026\006\017\016\ \023\024\007)Tj 0 Tw (-)Tj -0.001 Tw T* (\b\024\007\024\r \022)Tj /Span<>> BDC ( )Tj EMC (\030\026\030\026\002\024\021\022\036, \r\026\035\017\007\026\006\017\017\ \017)Tj /Span<>> BDC ( )Tj EMC (\024\021\004\201\021\027\024\f\021\017 \n\024\007\036\035\036\005 )Tj 0 Tw T* (\n\026\001\017\027\027\024\020\024 \024\002\031\004\036\027\017\016.)Tj /T1_2 1 Tf 0.023 Tw 0 -2.436 TD (\224\030\032\255\020\034\036 \032\026\020\017\022\017\026)Tj /T1_0 1 Tf 0 Tw 0 -1.218 TD [(\025)-4.1(\024)-4.3(\027)1.7(\006)-6(\036)-6.8(\023)2.2(\006)-6(\017)-5.4(\016 \017)]TJ /Span<>> BDC ( )Tj EMC [(\007)-6(\017)2.7()-9.9(\026\005)1.8(\027 \017)-2.4(\f)3.1(\f)-38.9(\035)-6.8(\036)-19(\007)-4.4(\024)-4.3(\r)-8.9(\026\027)1.7(\017)-5.5(\016)13.7(:)]TJ /T1_3 1 Tf [( \223)101.4(\034)4.9(\033\b)1.9(\016)-0.9(\016)6.6(\036)]TJ /Span<>> BDC ( )Tj EMC [(\207)-2.1(.)43.8(\207)-2.1(.)]TJ /T1_0 1 Tf 0.539 Tw T* [(\224)-4.6(\002)-9.9(\024)0.7(\030 \017)]TJ /Span<>> BDC ( )Tj EMC [(\024)-11.8(\002)3(\030)-11.4(\026)-6.3(\002)-9.9(\024)-10.9(\021)-17.7(\022)-19.1(\026 \n)1.3(\026)-11.8(\021)-9.9(\036)-1.7(\030)-7.6(\017)-0.6(\026)-33.1(\035)-2.5(\024)-4.2(\r)10.3(:)]TJ /T1_3 1 Tf -0.001 Tc 0.54 Tw [( \205)18.9(\025)0.6(\b)-4.9(\023)22.8(\027)8.1(\037\016)5.6(\036)1(\037)]TJ /Span<>> BDC 19.376 0 Td ( )Tj EMC [(\213)92.9(.)28.3(\245)27.3(.)6.8(,)-1( )]TJ 0 Tc 0.844 Tw -19.376 -1.218 Td [(\210\016)-20.6(\027)3.3(\016)2.3(\020)12(\003)11.3(\021)12.8(\037)2.1(\030)]TJ /Span<>> BDC ( )Tj EMC [(\247)27(.)28.5()24.3(.)7.8(, \214)10.2(\037)4.3(\020\023)8.8(\021)-13.9(\030)10.2(\020)]TJ /Span<>> BDC ( )Tj EMC [(\214)19.4(.)29.4(\245)28.3(.)7.8(, \223)101.4(\016)6.6(\036)-0.8(\034)4.9(\033)5.9(\021)-13.9(\030)10.3(\020)]TJ /Span<>> BDC ( )Tj EMC [(\202)65(.)29.3(\223)122(.)7.8(, )]TJ -0.029 Tc 0.029 Tw T* [(\t)-13.9(\037)-20.3(\036)-35.6(\027)-25.7(\034)-19.4(\036)-26.9(\037)]TJ /Span<>> BDC 3.391 0 Td ( )Tj EMC [()-4.7(.\200.)]TJ /T1_0 1 Tf 0.018 Tc 1.344 Tw -3.391 -1.218 Td [(\224)35.2(\021)-3.5(\026)6.2(\021\017)15.6(\f)-18(\021\017)22.5(\004)9.8(\036)7.6(\f)16.4(\022)-1.1(\026)-3(\016)18( \024)6.2(\002)21(\030)6.6(\026)11.7(\002)8.2(\024)7.1(\021\022)-1.1(\026)21.7(:)]TJ /T1_3 1 Tf -0.001 Tc 1.363 Tw 12.711 0 Td [( \205)18.9(\025)0.5(\b)-4.8(\023)22.8(\027)8(\037\016)5.7(\036)1.1(\037)]TJ /Span<>> BDC 5.842 0 Td ( )Tj EMC [(\213)92.9(.)28.3(\245)27.3(.)6.8(,)-1( )]TJ 0 Tc 0 Tw -18.553 -1.218 Td [(\223)101.4(\034)4.9(\033\b)1.9(\016)-0.9(\016)6.6(\036)]TJ /Span<>> BDC ( )Tj EMC [(\207)-2(.)43.7(\207)-2.1(.)]TJ /T1_0 1 Tf 0.002 Tc -0.002 Tw 23.244 41.405 Td [(\203)7.2(\026\023)4.2(\017\f)-10.8(\026)1.7(\027)3.7(\017)-6.7(\036)2.1( \021)-7.9(\036)-3.4(\022\f)-34(\021)-19.5(\026)5.7(:)]TJ /T1_3 1 Tf 0 Tc 0 Tw 7.694 0 Td [( \205)19.9(\025)1.5(\b)-3.8(\023)23.8(\027)9(\037)1(\016)6.6(\036)2.1(\037)]TJ /Span<>> BDC ( )Tj EMC [(\213)93.9(.)29.3(\245)28.3(.)7.8(, \210\016)-20.6(\027)3.3(\016)2.3(\020)12(\003)11.3(\021)12.7(\037)2.1(\030)]TJ /Span<>> BDC ( )Tj EMC [(\247)27.1(.)28.5()24.3(.)]TJ /T1_0 1 Tf -7.694 -1.218 Td [(\217)5.5(\036)-19(\007)-20.1(\026\022)-32.6(\021)-17.7(\017)1.4(\030)-11.8(\024)-4.2(\r)-9(\026\027)1.8(\017)-8.7(\036)6.5(:)]TJ /T1_3 1 Tf [( \223)101.4(\034)4.9(\033\b)1.9(\016)-0.9(\016)6.6(\036)]TJ /Span<>> BDC ( )Tj EMC [(\207)-2(.)43.7(\207)-2.1(.)]TJ /T1_2 1 Tf 0.023 Tw 0 -2.436 TD (AUTHORS CONTRIBUTION)Tj /T1_0 1 Tf 0 Tw 0 -1.218 TD [(C)-6.5(o)0.8(nce)-0.7(p)-12.3(t a)2.4(n)-4.6(d d)-5.4(e)-13.3(s)-16.6(i)3.2(g)1.2(n o)-2.2(f)]TJ /Span<>> BDC ( )Tj EMC [(t)-16.7(h)-5.3(e s)-19.9(t)-12.8(ud)-10.9(y)-11.8(:)]TJ /T1_3 1 Tf -0.002 Tc 0.002 Tw [( S)3.6(e)-3.7(rg)-4.5(e)-4.5(y)]TJ /Span<>> BDC 16.129 0 Td ( )Tj EMC (S.)Tj /Span<>> BDC 0.99 0 Td ( )Tj EMC [(G)-3.4(o)-0.7(r)-0.6(d)-2.9(e)-8.2(e)-6(v)]TJ /T1_0 1 Tf 0 Tc 0.332 Tw -17.119 -1.218 Td [(C)-6.5(o)-5.8(l)-19(l)-14.3(e)-9.4(c)-32.5(t)-37.3(i)3.2(o)0.8(n a)2.4(n)-4.6(d p)-3.8(r)-6(o)-7(ce)-13.2(s)-12.8(s)-16.6(i)7.1(n)-1.9(g o)-2.3(f)]TJ /Span<>> BDC ( )Tj EMC [(m)1.7(a)-8.3(t)-15.2(e)-2.1(r)-48(i)5.1(a)-1.5(l)-22.5(:)]TJ /T1_3 1 Tf [( R)10.2(u)4.6(k)-18.5(iy)3.8(a)-4.8(t)]TJ /Span<>> BDC ( )Tj EMC [(S)15.2(h)13.6(. )]TJ 0.212 Tw 0 -1.218 TD [(A)6(b)-5.9(d)5.2(u)2.8(l)3.4(a)-4.5(e)-4(v)10.8(a)-14(, Y)39.3(a)-0.8(n)4.8(a)]TJ /Span<>> BDC ( )Tj EMC [(V)53.1(.)]TJ /Span<>> BDC ( )Tj EMC [(B)0.8(e)-1.9(l)4.8(e)-2.6(n)7.5(k)15.9(a)-5.9(y)3.8(a)-14(, M)5.2(ar)-35.3(i)6(a)-0.8(m)]TJ /Span<>> BDC ( )Tj EMC [(S)15.3(h)13.6(. M)5.2(a)-0.8(n)8.3(u)4.5(k)-21.7(y)3.8(a)-0.8(n)-6(, )]TJ 0 Tw T* [(T)-2.7(i)5.8(g)2.9(r)7.7(a)-0.8(n)]TJ /Span<>> BDC ( )Tj EMC [(G)-1.3(.)]TJ /Span<>> BDC ( )Tj EMC [(G)-1.4(e)-4(v)7.6(o)1.3(r)-2.5(k)-21.7(y)3.8(a)-0.8(n)-6(, V)25.9(al)4.8(e)-1.7(r)-35.2(i)5.9(a)]TJ /Span<>> BDC ( )Tj EMC [(I)2.4(.)]TJ /Span<>> BDC ( )Tj EMC [(P)30.8(a)-4.4(v)0.9(l)3(o)-0.6(v)10.8(a)4.8(.)]TJ /T1_0 1 Tf -0.007 Tc 0.968 Tw T* [(St)-34.7(a)-15.4(t)-44.4(i)-4.3(s)-27(t)-44.4(i)-1.8(c)-18.8(a)-8.5(l)-7( p)-10.8(r)-13(o)-14(c)-6.8(e)-20.3(s)-19.8(s)-23.6(in)-8.9(g)2(:)]TJ /T1_3 1 Tf 0 Tc 0.961 Tw 10.049 0 Td [( R)10.2(u)4.6(k)-18.5(iy)3.8(a)-4.8(t)]TJ /Span<>> BDC ( )Tj EMC [(S)15.4(h)13.5(. A)6(b)-5.9(d)5.2(u)2.8(l)3.3(a)-4.5(e)-4(v)10.8(a)-14(, )]TJ -0.002 Tc 0.002 Tw -10.049 -1.218 Td [(S)3.6(e)-3.7(rg)-4.5(e)-4.5(y)]TJ /Span<>> BDC 2.567 0 Td ( )Tj EMC (S.)Tj /Span<>> BDC 0.99 0 Td ( )Tj EMC [(G)-3.4(o)-0.7(r)-0.6(d)-2.9(e)-8.2(e)-6(v)]TJ /T1_0 1 Tf -0.052 Tc 0.052 Tw -3.557 -1.218 Td [(Te)-75.9(x)-88(t)-52( w)-73(r)-99.9(i)-58(t)-89.4(i)-44.9(n)-53.9(g)-43(:)]TJ /T1_3 1 Tf 0 Tc 0 Tw 5.233 0 Td [( R)10.2(u)4.6(k)-18.5(iy)3.9(a)-4.9(t)]TJ /Span<>> BDC ( )Tj EMC [(S)15.3(h)13.6(. A)6(b)-5.9(d)5.3(u)2.8(l)3.3(a)-4.5(e)-4(v)10.8(a)-14(, Y)39.3(a)-0.8(n)4.8(a)]TJ /Span<>> BDC ( )Tj EMC [(V)53.2(.)]TJ /Span<>> BDC ( )Tj EMC [(B)0.8(e)-1.9(l)4.8(e)-2.6(n)7.5(k)15.9(a)-5.9(y)3.8(a)]TJ /T1_0 1 Tf 0.006 Tc -0.006 Tw -5.233 -1.218 Td [(E)11.6(dit)-31.4(i)13.1(n)4.1(g)15(:)]TJ /T1_3 1 Tf -0.002 Tc 0.002 Tw 3.238 0 Td [( S)3.6(e)-3.7(rg)-4.5(e)-4.5(y)]TJ /Span<>> BDC 2.8 0 Td ( )Tj EMC (S.)Tj /Span<>> BDC 0.99 0 Td ( )Tj EMC [(G)-3.4(o)-0.7(r)-0.6(d)-2.9(e)-8.2(e)-6(v)]TJ /T1_2 1 Tf 0 Tc 0.023 Tw -7.027 -2.436 Td (\255\026\036\031\036\025\034\226 \017\223 \032\026\020\017\022\032\225 \(\ ORCID\))Tj /T1_0 1 Tf 0.498 Tw T* (\202\002\007\031\035\026\036\r\026 \217\031\022\017\016\021 \221\026\n\017\ \035\034\036\r\027\026)Tj /Span<>> BDC ( )Tj EMC (\227 ORCID: 0009-)Tj 0 Tw ( )Tj T* (0004-6399-963X)Tj 0.332 Tw T* (\215\026\r\035\024\r\026 \200\026\035\036\030\017\016 \236\020\024\030\036\ \r\027\026)Tj /Span<>> BDC ( )Tj EMC (\227 ORCID: 0000-0002-)Tj 0 Tw ( )Tj T* (0899-0809)Tj 0.322 Tw T* (\206\036\r\024\030\022\016\027 \230\017\020\030\026\027 \206\026\020\017\ \022\024\r\017\004)Tj /Span<>> BDC ( )Tj EMC (\227 ORCID: 0009-0008-)Tj 0 Tw ( )Tj T* (3486-302X)Tj 0.115 Tw T* [(\207\036\035\036\027\034\022\026\016 )0.6(\233\027\026 )0.5(\200\035\026\007\017\n\017\030\024\r\027\026)]TJ /Span<>> BDC ( )Tj EMC 12.935 0 Td [(\227 )0.5(ORCID: )0.6(0000-0003-)]TJ 0 Tw ( )Tj -12.935 -1.218 Td (2163-1752)Tj 0.209 Tw T* (\204\026\027\031\022\016\027 \204\026\030\017\026\n \221\017\030\026\022\ \024\r\027\026)Tj /Span<>> BDC ( )Tj EMC (\227 ORCID: 0000-0002-)Tj 0 Tw ( )Tj T* (5084-4872)Tj 0.427 Tw T* [(\206\024\030\007\036\036\r )0.5(\224\036\030\020\036\005 )0.6(\224\036\030\020\036\036\r\017\004)]TJ /Span<>> BDC ( )Tj EMC 12.311 0 Td [(\227 )0.5(ORCID: )0.6(0000-0002-)]TJ 0 Tw ( )Tj -12.311 -1.218 Td (9303-8379)Tj /T1_2 1 Tf 0.023 Tw 0 -2.436 TD (INFORMATION ABOUT THE)Tj /Span<>> BDC ( )Tj EMC (AUTHORS \(ORCID\))Tj /T1_0 1 Tf 0 Tw 0 -1.218 TD [(A)-14(bdul)-15.9(aev)-15(a S)-16(h. Ruk)-15.9(iy)22(a)15(t)]TJ /Span<>> BDC ( )Tj EMC (\227 0009-0004-6399-963X)Tj T* [(V)25(aler)-37(ia I. P)40.1(avl)30(ov)-15(a)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0002-0899-0809)Tj T* [(T)35(igr)-33(an G. Gevor)-23.9(k)-32(y)22(an)]TJ /Span<>> BDC ( )Tj EMC (\227 0009-0008-3486-302X)Tj T* [(Y)50(ana V. Belenk)-16.9(a)15(y)22(a)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0003-2163-1752)Tj T* [(Mar)-37(iam S)-15.9(h. Manuk)-32(y)22(an)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0002-5084-4872)Tj T* [(Ser)-32(ge)-11(y S. Gor)-23.9(deev)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0002-9303-8379)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 70.936 274.2439 Tm [(\r\031\024\034\033)48(\026)45(\024)-10(\223\033)48(\026/REFERENCES)]TJ 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.004 Tc 0.349 Tw 8 0 0 8 70.8661 261.4092 Tm [(1)0.5(.)]TJ /Span<>> BDC 0.803 0 Td ( )Tj EMC 0.503 0 Td [(J)0.5(e)0.5(o)0.5(n)]TJ /Span<>> BDC 1.951 0 Td ( )Tj EMC [(Y)0.5(,)0.5( e)-11.5(t)]TJ /Span<>> BDC 2.683 0 Td ( )Tj EMC [(a)0.5(l)0.5(.)0.5( M)0.5(a)-16.5(c)0.5(h)0.5(i)0.5(n)0.5(e)0.5( l)0.6(ea)0.6(r)-14.5(n)0.5(i)0.5(n)0.5(g)0.5( b)0.5(a)0.5(s)0.5(e)0.5(d)0.5( p)25.6(r)-23.5(e)0.5(d)0.5(i)0.5(c)-15.5(t)-31.5(i)0.5(o)0.5(n)0.5( o)0.6(f)]TJ /Span<>> BDC 18.691 0 Td ( )Tj EMC [(r)-23.4(e)0.5(c)0.5(u)0.5(r)]TJ 0 Tc 0 Tw 2.654 0 Td (-)Tj 0.013 Tc 0.461 Tw -27.286 -1.25 Td [(r)-23.5(e)0.5(n)0.5(c)0.5(e a)0.5(f)-27.5(te)0.5(r)0.5( c)0.5(u)0.5(r)-32.5(a)15.4(t)-31.5(i)-15.5(v)0.5(e)0.5( r)-23.5(e)0.5(se)0.5(c)-15.5(t)-31.5(i)0.5(o)0.5(n f)0.5(o)0.5(r)0.5( r)-23.5(e)0.5(c)-15.5(t)15.5(a)0.5(l)0.5( c)0.5(a)0.5(n)0.5(ce)0.5(r)0.5(.)0.5( )]TJ /T1_3 1 Tf [(P)0.5(L)0.5(o)0.5(S)0.5( On)0.5(e)]TJ /T1_0 1 Tf 0 Tc 0 Tw 27.342 0 Td (. )Tj -27.342 -1.25 Td (2023;18\(12\):e0290141.)Tj -0.033 Tw 0 -1.25 TD (2.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(T)40(ang)]TJ /Span<>> BDC ( )Tj EMC [(M, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Ma)-17(chine lear)-14.9(ning based p)25(r)-32(o)-16(gnost)-32(ic model of)]TJ /Span<>> BDC ( )Tj EMC (Chinese )Tj 0.261 Tw -1.296 -1.25 Td [(medic)-24(ine af)-56(fec)-16(t)-32(ing t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(r)-23.9(ecur)-24(r)-24(ence and me)-12(t)15(ast)15(asis of)]TJ /Span<>> BDC ( )Tj EMC [(I-III st)15(a)-17(ge )]TJ 0.001 Tc 0.349 Tw T* [(col)30.4(or)-23.6(ec)-15.6(t)15.3(al cancer: A)]TJ /Span<>> BDC ( )Tj EMC [(r)-23.6(e)-11.6(tr)-31.6(ospec)-15.6(t)-31.6(i)-15.6(ve stud)17.4(y in China. )]TJ /T1_3 1 Tf [(F)27.4(ront Oncol)]TJ /T1_0 1 Tf 0 Tc 0 Tw (. )Tj T* (2022;12:1044344.)Tj 0.01 Tc 0.357 Tw T* [(3)0.5(.)]TJ /Span<>> BDC ( )Tj EMC 1.325 0 Td [(T)35.5(in)0.5(g)]TJ /Span<>> BDC ( )Tj EMC [(WC)0.5(,)0.5( e)-11.5(t)]TJ /Span<>> BDC 5.196 0 Td ( )Tj EMC [(al)0.5(. M)0.5(a)-16.6(c)0.5(hi)0.5(n)0.5(e L)35.4(e)0.5(a)0.5(r)-14.6(n)0.5(i)0.5(ng)0.5( i)0.5(n)0.5( P)35.5(r)-23.5(ed)0.5(ic)-15.5(t)-31.5(io)0.5(n)0.5( o)0.5(f)]TJ /Span<>> BDC ( )Tj EMC [(S)0.5(ec)0.5(on)0.5(d)10( )]TJ 0 Tc 0.121 Tw -6.521 -1.25 Td [(P)35(r)-37(imar)-23.9(y Cancer and R)13(ecur)-24(r)-24(ence in Col)30(or)-24(ec)-16(t)15(al Cancer. )]TJ /T1_3 1 Tf (Int J Med Sci)Tj /T1_0 1 Tf 0 Tw (. )Tj T* (2020;17\(3\):280\226291.)Tj 0.124 Tw T* (4.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(A)-25(chil)30.1(onu)]TJ /Span<>> BDC ( )Tj EMC [(OJ, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. P)35(r)-24(edic)-16(t)-31.9(ing Col)30(or)-24(ec)-16(t)15(al Cancer R)13(ecur)-24(r)-23.9(ence and )]TJ 0.005 Tc 0.35 Tw -1.296 -1.25 Td [(P)39.6(a)14.6(t)-32.5(ient Sur)-32.5(v)-16.4(i)-16.4(v)-15.4(al Using Super)-32.4(v)-16.4(ised Ma)-17.4(chine L)34.6(ear)-15.4(ning App)24.5(r)-32.4(oa)-17.4(ch:)5( )]TJ 0.01 Tc 0.364 Tw T* (A)Tj /Span<>> BDC ( )Tj EMC [(S)-15.8(out)-12.8(h Afr)-36.7(ican P)10.3(opul)-15.7(a)15.2(t)-31.7(ion-Based S)15.3(tud)17.3(y. )]TJ /T1_3 1 Tf [(F)27.2(ront Public Health.)]TJ /T1_0 1 Tf 0 Tc 0 Tw 27.638 0 Td ( )Tj -27.638 -1.25 Td (2021;9:694306.)Tj 0.046 Tw T* (5.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (Chen)Tj /Span<>> BDC ( )Tj EMC [(PC, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC (al. A)Tj /Span<>> BDC ( )Tj EMC [(P)35(r)-24(edic)-16(t)-32(ion M)-24(odel for T)60(umor R)13(ecur)-23.9(r)-24(ence in S)15(t)15(a)-17(ge )]TJ 0.193 Tw -1.296 -1.25 Td [(II-III Col)30.1(or)-24(ec)-16(t)15(al Cancer P)40(a)15(t)-32(ients: F)10(r)-32(om a)]TJ /Span<>> BDC ( )Tj EMC [(Ma)-16.9(chine L)35(ear)-15(ning M)-24(odel )]TJ 0.023 Tw T* [(t)17(o)]TJ /Span<>> BDC ( )Tj EMC [(Genomic P)35(r)-32(of)-28(il)-31(ing. )]TJ /T1_3 1 Tf 0 Tw (Biomedicines)Tj /T1_0 1 Tf 0.023 Tw (. 2022;10\(2\):340.)Tj 0.091 Tw T* (6.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Al)-31(inia)]TJ /Span<>> BDC ( )Tj EMC [(S, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. P)35(r)-24(edic)-16(t)-32(ing mor)-21.9(t)15(al)-31(i)-24(t)-9.9(y and r)-23.9(ecur)-24(r)-24(ence in col)30.1(or)-24(ec)-16(t)15(al )]TJ 0.007 Tc 0.349 Tw -1.296 -1.25 Td [(cancer: Com)10.3(p)32.2(ar)-32.7(a)15.3(t)-31.8(i)-15.7(ve assess)26.3(ment of)]TJ /Span<>> BDC ( )Tj EMC [(p)25.2(r)-23.7(edic)-15.8(t)-31.7(i)-15.7(ve models. )]TJ /T1_3 1 Tf -0.007 Tw (Heliyon)Tj /T1_0 1 Tf 0 Tc 0 Tw (. )Tj 29.055 22.5 Td (2024;10\(6\):e27854.)Tj 0.025 Tw T* (7.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(K)-16(a)15(yikc)-23.9(io)-16(gl)35(u)]TJ /Span<>> BDC ( )Tj EMC [(E, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Ma)-16.9(chine lear)-15(ning for p)25(r)-23.9(edic)-16(t)-32(ing col)30(on cancer )]TJ 0 Tw -1.296 -1.25 Td [(r)-24(ecur)-23.9(r)-24(ence. )]TJ /T1_3 1 Tf 0.023 Tw 4.881 0 Td (Surgical Oncology.)Tj /T1_0 1 Tf ( 2024;54:102079.)Tj 0.13 Tw -4.881 -1.25 Td (8.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (Susi\267)Tj /Span<>> BDC ( )Tj EMC [(D, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Ar)-22(t)-32(if)-27.9(ic)-24(ial intell)-30.9(igence based per)-10(sonal)-30.9(ized p)25(r)-24(edic)]TJ 0 Tw (-)Tj 0.261 Tw -1.296 -1.25 Td [(t)-32(i)-16(ve sur)-31.9(v)-16(i)-16(v)-15(al among col)30(or)-23.9(ec)-16(t)15(al cancer p)32(a)15(t)-32(ients. Com)10.1(put Me)-12(t)-13(hods )]TJ 0.023 Tw T* [(P)35(r)-32(o)-16(gr)-33(ams Biomed. 2023;231:107435.)]TJ 0.185 Tw T* (9.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Gupt)15(a)]TJ /Span<>> BDC ( )Tj EMC [(P, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. P)35(r)-24(edic)-15.9(t)-32(ion of)]TJ /Span<>> BDC ( )Tj EMC [(Col)30(on Cancer S)15(t)15(a)-17(ges and Sur)-32(v)-16(i)-16(v)-14.9(al )]TJ 0.308 Tw -1.296 -1.25 Td [(P)30(er)-37(iod wi)-24(t)-13(h Ma)-17(chine L)35(ear)-15(ning App)25(r)-31.9(oa)-17(ch. )]TJ /T1_3 1 Tf (Cancers \(Basel\).)Tj /T1_0 1 Tf ( 2019; )Tj 0 Tw T* (11\(12\).)Tj 0.027 Tw T* (10.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Hu)Tj /Span<>> BDC ( )Tj EMC [(J, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Constr)-22(uc)-16(t)-31.9(ion and v)-15(al)-30.9(id)42(a)15(t)-32(ion of)]TJ /Span<>> BDC ( )Tj EMC (a)Tj /Span<>> BDC ( )Tj EMC [(p)25(r)-32(o)-16(gr)-23.9(ession p)25(r)-24(edic)]TJ 0 Tw (-)Tj 0.041 Tw -1.796 -1.25 Td [(t)-32(ion model for l)30(o)-16(call)35.1(y ad)-17(v)-15(anced r)-24(ec)-15.9(t)15(al cancer p)32(a)15(t)-31.9(ients r)-24(ecei)-15.9(ved neo)]TJ 0 Tw (-)Tj 0.148 Tw T* [(ad)17(juv)-15(ant chemor)-33(adio)17(t)-13(her)-32.9(apy foll)30(o)-13.9(wed b)12(y t)17(o)17(t)15(al mesor)-24(ec)-16(t)15(al e)-18(x)-13(c)-23.9(ision )]TJ 0.023 Tw T* [(based on ma)-17(chine lear)-15(ning. )]TJ /T1_3 1 Tf [(F)27(ront Oncol.)]TJ /T1_0 1 Tf ( 2023;13:1231508.)Tj 0.206 Tw T* (11.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(L)35(eonar)-24(d)]TJ /Span<>> BDC ( )Tj EMC [(G, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Ma)-17(chine L)35(ear)-15(ning Im)10(p)25(r)-32(oves P)35(r)-24(edic)-16(t)-31.9(ion O)-24(ver )]TJ 0.12 Tw -1.796 -1.25 Td [(L)35(o)-16(gist)-32(ic )0.5(R)13(egr)-24(ession )0.5(on R)13(esec)-16(ted )0.5(Col)30(on Cancer )0.5(P)40(a)15(t)-32(ients. )]TJ /T1_3 1 Tf 23.14 0 Td [(J Surg )0.5(R)21(es.)]TJ /T1_0 1 Tf 0 Tw ( )Tj -23.14 -1.25 Td (2022;275:181\226193.)Tj 0.079 Tw T* (12.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(N)-14(opour)]TJ /Span<>> BDC ( )Tj EMC [(R. Devel)30(opment of)]TJ /Span<>> BDC ( )Tj EMC [(P)35(r)-24(edic)-15.9(t)-32(ion M)-24(odel for 5-year Sur)-32(v)-16(i)-16(v)-15(al )]TJ 0.023 Tw -1.796 -1.25 Td (of)Tj /Span<>> BDC ( )Tj EMC [(Col)30(or)-23.9(ec)-16(t)15(al Cancer. )]TJ /T1_3 1 Tf [(Cancer Infor)-13.9(m.)]TJ /T1_0 1 Tf ( 2024;23:11769351241275889.)Tj 0.275 Tw T* (13.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Ji)Tj /Span<>> BDC ( )Tj EMC [(XL, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. P)35(r)-32(o)-16(gnost)-32(ic p)25(r)-24(edic)-16(t)-32(ion models for post)17(oper)-33(a)15(t)-32(i)-16(ve )]TJ 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 0 Tw 7.5 0 0 7.5 70.8661 759.8869 Tm [(\007\003\032)50(\n\n\217\n)-21(\035\030\002)]TJ 53.418 0 Td [(MET)30(A)-41(-)-41.9(ANAL)30(Y)30(SIS)]TJ -53.418 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 2)69(4, \023\0224, 202)23(5)]TJ 43.013 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 2)69(4, \023\0224, 202)23(5)]TJ /T1_5 1 Tf 25 0 0 25 20.7651 56.0378 Tm (136)Tj ET endstream endobj 1405 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1406 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1407 0 obj <>/Font<>/ProcSet[/PDF/Text/ImageC]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1408 0 obj <>/Font<>/ProcSet[/PDF/Text/ImageB/ImageC]/XObject<>>>/TrimBox[0.0 0.0 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\(a\022s)10(y)10(stematic r)31(e)11(vie)11(w and meta-analy)10(sis\))]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0.101 Tw 10 0 0 10 42.5197 590.8719 Tm (\203\026\017\002\024\035\036\036 \004\026\f\021\024 \017\f\023\024\035\034\ \031\036\n\t\n \026\035\020\024\030\017\021\n\024\n \024\022\026\026\035\ \f\016 )Tj 0.079 Tw 0 -1.218 TD [(R)-10(and)-16(om F)10(or)-23.9(est, \023\030\017\n\036\027\036\027\027\t\005 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC [(65% \r\022\035\033\004\201\027\027\t\b )0.5(\017\f)]TJ 0 Tw (-)Tj 0.114 Tw 0 -1.218 TD (\f\035\036\007\024\r\026\027\017\005. \225\021\024\021 \n\036\021\024\007\ \b\026\030\026\022\021\036\030\017\031\036\021\f\016 \031\f\021\024\005\ \004\017\r\024)Tj 0 Tw (-)Tj 0.065 Tw 0 -1.218 TD (\f\021\034\033 \017)Tj /Span<>> BDC ( )Tj EMC (\r\t\f\024\022\024\005 \f\023\024\f\024\002\027\024\f\021\034\033 \022)Tj /Span<>> BDC ( )Tj EMC (\024\002\027\026\030\031\032\036\027\017\033 \027\036\035\017)Tj 0 Tw (-)Tj 0.056 Tw T* [(\027\036\005\027\t\b \026\r\017\f\017\n\024\f\021\036\005 )0.5(\n\036\032\007\031 \023\036\030\036\n\036\027\027\t\n\017. \200\t\f\024\022\ \017\036 )]TJ 0.035 Tw T* [(\023\024\022\026\026\021\036\035\017 \220\235\235\036\022\021\017\r\027\ \024\f\021\017 \026\035\020\024\030\017\021\n\026 R)-10(and)-16(om F)10(or)-23.9(est )]TJ 0.121 Tw T* (\002\t\035\017 \023\030\024\007\036\n\024\027\f\021\030\017\030\024\r\026\ \027\t \r)Tj /Span<>> BDC ( )Tj EMC (\030\026\002\024\021\026\b Jeon \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021., )Tj 0.05 Tw T* (2023 \020. \017)Tj /Span<>> BDC ( )Tj EMC (Chen \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021., 2022 \020., \020\007\036 \024\027 \007\024\f\021\017\020\ \027\026\004\036)Tj 0 Tw (-)Tj 0.1 Tw T* [(\027\017\005 A)17(UC 0,84 \017)]TJ /Span<>> BDC ( )Tj EMC (\021\024\004\027\024\f\021\017 \002\024\035\036\036 80% [1,5]. \203\026\017\ \002\024\035\036\036 )Tj 0.131 Tw T* (\r\t\f\024\022\017\036 \023\024\022\026\026\021\036\035\017 \023\030\024\ \020\027\024\f\021\017\004\036\f\022\024\005 \021\024\004\027\024\f\021\017\ \f\030\036)Tj 0 Tw (-)Tj 0.478 Tw T* (\007\017 \030\026\f\f\n\024\021\030\036\027\027\t\b \017\f\f\035\036\007\ \024\r\026\027\017\005 \002\t\035\017 \023\024\035\031\004\036\027\t )Tj 0.193 Tw T* (\023\030\017)Tj /Span<>> BDC ( )Tj EMC (\017\f\023\024\035\034\024\r\026\027\017\017 \n\036\021\024\007\024\r \020\ \030\026\007\017\036\027\021\027\024\020\024 \002\031\f\021\017\027\020\026\ )Tj 0.445 Tw T* [(\(X)16(GBo)-16(ost\). \203\026\023\030\017\n\036\030, \r)]TJ /Span<>> BDC ( )Tj EMC [(\017\f\f\035\036\007\024\r\026\027\017\016\b R)11(odr)-36.9(iguez )]TJ 0.013 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC [(\f\024\026\r\021., 2023 \020., Er)-24(k)-16.9(an \017)]TJ /Span<>> BDC ( )Tj EMC (\f\024\026\r\021., 2024)Tj /Span<>> BDC ( )Tj EMC (\020., \017)Tj /Span<>> BDC ( )Tj EMC [(Gupt)15(a \017)]TJ /Span<>> BDC ( )Tj EMC (\f\024)Tj 0 Tw (-)Tj 0.169 Tw T* [(\026\r\021., )0.5(2019 \020. \026\035\020\024\030\017\021\n )0.5(X)16(GBo)-16(ost )0.5(\007\036\n\024\027\f\021\030\017\030\024\r\026\035 )0.5(\002\024)]TJ 0 Tw (-)Tj 0.107 Tw T* [(\035\036\036 )0.5(\r\t\f\024\022\017\036 )0.5(\027\026\004\036\027\017\016 )0.5(A)17(UC )0.5(\023\024)]TJ /Span<>> BDC ( )Tj EMC 13.017 0 Td [(\f\030\026\r\027\036\027\017\033 )0.6(\f)]TJ /Span<>> BDC ( )Tj EMC (\007\030\031\020\017\n\017 )Tj 0.229 Tw -13.017 -1.218 Td (\023\024\007\b\024\007\026\n\017, \007\024\f\021\017\020\026\016 0,92\226\ 0,94, \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\004\031\r\f\021\r\017\021\036\035\034\027\024)Tj 0 Tw (-)Tj 0.067 Tw T* (\f\021\017 \007\024)Tj /Span<>> BDC ( )Tj EMC (95% \017)Tj /Span<>> BDC ( )Tj EMC (\f\023\036\006\017\235\017\004\027\024\f\021\017 \007\024)Tj /Span<>> BDC ( )Tj EMC (94% [7,9,17]. \204\036\021\024\007 )Tj 0.449 Tw T* [(\024\023\024\030\027\t\b \r\036\022\021\024\030\024\r \(S)-13(VM\) \021\026\022\032\036 \023\030\024\007\036\n\024\027\f\021\030\017\030\ \024)]TJ 0 Tw (-)Tj 0.294 Tw T* (\r\026\035 \r\t\f\024\022\031\033 \220\235\235\036\022\021\017\r\027\024\ \f\021\034. \224\024\020\035\026\f\027\024 \017\f\f\035\036\007\024\r\026\ )Tj 0 Tw (-)Tj 0.14 Tw T* [(\027\017\033 T)35(ing \017)]TJ /Span<>> BDC ( )Tj EMC (\f\024\026\r\021., 2020 \020., \007\026\027\027\t\005 \026\035\020\024\030\ \017\021\n \007\024\f\021\017\020 )Tj 0.188 Tw T* [(A)17(UC )0.5(0,87, )0.5(\021\024\004\027\024\f\021\017 )0.6(83% )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 11.543 0 Td [(\f\023\036\006\017\235\017\004\027\024\f\021\017 )0.6(86% )0.5([3]. )]TJ 0.512 Tw -11.543 -1.218 Td (\202\027\026\035\024\020\017\004\027\t\036 \030\036\031\035\034\021\026\ \021\t \023\030\036\007\f\021\026\r\035\036\027\t \r)Tj /Span<>> BDC ( )Tj EMC (\030\026\002\024\021\036 )Tj 0.152 Tw T* [(A)-25(chil)30.1(onu \017)]TJ /Span<>> BDC ( )Tj EMC [(\f\024\026\r\021., 2021 \020., \020\007\036 S)-13(VM \007\024\f\021\017\020 A)17(UC 0,80 )]TJ 0.224 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\021\024\004\027\024\f\021\017 87,8% [4]. \210\007\027\026\022\024, \027\ \036\f\n\024\021\030\016 \027\026)Tj /Span<>> BDC ( )Tj EMC (\022\024\027\022\031)Tj 0 Tw (-)Tj 0.142 Tw T* [(\030\036\027\021\027\t\036 )0.6(\023\024\022\026\026\021\036\035\017, )0.5(\n\024\007\036\035\017 )0.5(S)-13(VM )0.5(\017\n\036\033\021 )0.6(\024\020\030\026\027\017\004\036\027)]TJ 0 Tw (-)Tj 0.034 Tw T* (\027\031\033 \n\026\f\001\021\026\002\017\030\031\036\n\024\f\021\034 \023\ \030\017)Tj /Span<>> BDC ( )Tj EMC (\031\r\036\035\017\004\036\027\017\017 \030\026\n\036\030\027\024\f\021\ \017 )Tj 0.059 Tw T* [(\007\026\027\027\t\b )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC 4.141 0 Td [(\021\030\036\002\031\033\021 )0.6(\021\013\026\021\036\035\034\027\024\005 )0.5(\027\026\f\021\030\024\005\022\017 )0.6(\020\017\023\036\030\023\026\030\026)]TJ 0 Tw (-)Tj 0.026 Tw -4.141 -1.218 Td (\n\036\021\030\024\r, \004\021\024 \f\027\017\032\026\036\021 \017\b \023\ \030\026\022\021\017\004\036\f\022\031\033 \023\030\017\n\036\027\017\n\024\ \f\021\034. )Tj -0.026 Tw T* (\200)Tj /Span<>> BDC ( )Tj EMC [(\024\021\035\017\004\017\036 \024\021 \026\027\f\026\n\002\035\036\r\t\b\ \n\036\021\024\007\024\r, \021\026\022\017\b \022\026\022 R)-10(and)-16(om )]TJ -0.041 Tw T* [(F)10(or)-24(est \017)]TJ /Span<>> BDC ( )Tj EMC [(X)16(GBo)-16(ost, \n\024\007\036\035\017 S)-13(VM \n\036\027\036\036 \031\f\021\024\005\004\017\r\t \022)]TJ /Span<>> BDC ( )Tj EMC (\001\031\n\031 )Tj 0.199 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\007\026\027\027\t\b \017)Tj /Span<>> BDC ( )Tj EMC (\021\030\036\002\031\033\021 \027\026\004\017\021\036\035\034\027\t\b \r\ \t\004\017\f\035\017\021\036\035\034\027\t\b )Tj -0.001 Tw 0 -1.218 TD (\030\036\f\031\030\f\024\r \007\035\016 \024\002\030\026\002\024\021\022\ \017 \022\030\031\023\027\t\b \r\t\002\024\030\024\022. \203\026\017\n\036\ \027\036\036 )Tj -0.024 Tw 0 -1.218 TD [(\f\021\026\002\017\035\034\027\t\036 )0.6(\030\036\031\035\034\021\026\021\t )0.6(\023\030\024\007\036\n\024\027\f\021\030\017\030\024\r\026\035 )0.5(\026\035\020\024\030\017\021\n )]TJ 0.059 Tw 0 -1.218 TD [(K-Near)-23.9(est Neighbor)-10(s \(KNN\), \022\024\021\024\030\t\005 \f\031\013\036\f\021\r\036\027\027\ \024 \026)]TJ 0 Tw (-)Tj -0.014 Tw T* (\r\017\f\017\021 \024\021 \024\002\255\201\n\026 \017)Tj /Span<>> BDC ( )Tj EMC (\f\021\030\031\022\021\031\030\t \007\026\027\027\t\b. \200)Tj /Span<>> BDC ( )Tj EMC (\017\f\f\035\036\007\024\r\026\027\017\017 )Tj 0.068 Tw T* [(Gupt)15(a \017)]TJ /Span<>> BDC ( )Tj EMC [(\f\024\026\r\021., 2019\020., KNN \007\024\f\021\017\020 A)17.1(UC 0,75 [9]. \200)]TJ /Span<>> BDC ( )Tj EMC (\021\024 )Tj 0.129 Tw T* (\032\036 \r\030\036\n\016, \021\024\004\027\024\f\021\034 KNN \f\024\f\021\ \026\r\017\035\026 75%, \004\021\024 \031\f\021\031\023\026)Tj 0 Tw (-)Tj 0.102 Tw T* [(\036\021 R)-10(and)-15.9(om F)10(or)-24(est \(84%\) \017)]TJ /Span<>> BDC ( )Tj EMC [(X)16(GBo)-16(ost \(85%\) [9]. \230\026\022\032\036 )]TJ 0.186 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC [(\017\f\f\035\036\007\024\r\026\027\017\017 K)25(os \017)]TJ /Span<>> BDC ( )Tj EMC (\f\024\026\r\021., 2024 \020., KNN \023\024\022\026\026\035 )Tj 0.251 Tw T* [(A)17(UC 0,76, \004\021\024 \016\r\035\016\036\021\f\016 \b\031\007\001\017\n \ \023\024\022\026\026\021\036\035\036\n \f\030\036\007\017 )]TJ 0.001 Tw T* [(\r\f\036\b \030\026\f\f\n\024\021\030\036\027\027\t\b \n\036\021\024\007\ \024\r, \r\022\035\033\004\026\016 Suppor)-22(t V)30(ec)-16(t)17(or )]TJ 0 Tw T* [(Ma)-17(chine \(0,84\) \017)]TJ /Span<>> BDC ( )Tj EMC (\027\036\005\030\024\027\027\t\036 \f\036\021\017 \(0,76\) [15].)Tj 0.216 Tw 23.244 51.148 Td (\232\021\024 \022\026\f\026\036\021\f\016 \024\002\255\201\n\026 \r\t\002\ \024\030\024\022, \026\f\035\031\032\017\r\026\036\021 \r\027\017\n\026\ )Tj 0 Tw (-)Tj 0.219 Tw T* (\027\017\016 \021\024\021 \235\026\022\021, \004\021\024 \n\024\007\036\035\ \017, \030\026\030\026\002\024\021\026\027\027\t\036 \027\026)Tj /Span<>> BDC ( )Tj EMC (\024\020\030\026)Tj 0 Tw (-)Tj 0.251 Tw 0 -1.218 TD [(\027\017\004\036\027\027\t\b )0.6(\007\026\027\027\t\b, )0.5(\021\026\022 )0.6(\032\036 )0.5(\007\036\n\024\027\f\021\030\017\030\031\033\021 )0.6(\r\t\f\024\022\031\033 )]TJ 0.413 Tw 0 -1.218 TD (\023\030\024\020\027\024\f\021\017\004\036\f\022\031\033 \220\235\235\036\ \022\021\017\r\027\024\f\021\034. \200)Tj /Span<>> BDC ( )Tj EMC (\017\f\f\035\036\007\024\r\026\027\017\017 )Tj 0.083 Tw T* [(L)35(eonar)-24(d \017)]TJ /Span<>> BDC ( )Tj EMC (\f\024\026\r\021., 2022 \020., \020\007\036 \002\t\035\024 \023\030\024\026\ \027\026\035\017\017\030\024\r\026)Tj 0 Tw (-)Tj 0.251 Tw T* [(\027\024 )0.5(\024\020\030\026\027\017\004\036\027\027\024\036 )0.6(\022\024\035\017\004\036\f\021\r\024 )0.6(\023\030\017\027\026\022\024\r )0.6(\(\n\036\027\036\036 )0.5(10 )]TJ 0.08 Tw T* [(\023\036\030\036\n\036\027\027\t\b\), )0.6(\027\026\004\036\027\017\036 )0.6(A)17(UC )0.5(\r\026\030\034\017\030\024\r\026\035\024 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 18.391 0 Td (\007\017\026\023\026\024)Tj 0 Tw (-)Tj 0.014 Tw -18.391 -1.218 Td (\027\036 0,74\2260,75 \017)Tj /Span<>> BDC ( )Tj EMC (\021\024\004\027\024\f\021\034 76\22680%, \004\021\024 \f\r\017\007\036\021\ \036\035\034\f\021\r\031\036\021 )Tj -0.007 Tw T* (\024)Tj /Span<>> BDC ( )Tj EMC (\r\024\n\024\032\027\024\f\021\017 \030\026\030\026\002\024\021\022\017\ \023\030\024\020\027\024\f\021\017\004\036\f\022\017\b \n\024\007\036\035\ \036\005 )Tj 0.156 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\r\t\f\024\022\024\005 \f\021\036\023\036\027\034\033 \023\030\036\007\f\ \022\026\026\021\036\035\034\027\024\005 \f\023\024\f\024\002\027\024\f\ \021\017 )Tj 0.29 Tw T* [(\007\026\032\036 )0.5(\023\030\017)]TJ /Span<>> BDC ( )Tj EMC 4.649 0 Td [(\024\020\030\026\027\017\004\036\027\027\024\n )0.6(\024\002\255\201\n\036 )0.5(\017\f\b\024\007\027\t\b )0.6(\007\026\027\027\t\b )]TJ 0.017 Tw -4.649 -1.218 Td ([11]. \210\007\027\026\022\024 \r)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\034\001\017\027\f\021\r\036 \030\026\002\024\021 \(33,3%\) \ \002\t\035\024 \023\030\024)Tj 0 Tw (-)Tj 0.025 Tw T* (\026\027\026\035\017\017\030\024\r\026\027\024 \024\021 10 \007\024)Tj /Span<>> BDC ( )Tj EMC (15 \023\026\030\026\n\036\021\030\024\r, \004\021\024 \023\024\r\024\035\ \017)Tj 0 Tw (-)Tj 0.007 Tw T* (\035\024 \007\024\f\021\017\004\034 \024\023\021\017\n\026\035\034\027\024\ \020\024 \002\026\035\026\027\f\026 \n\036\032\007\031 \f\035\024\032\027\ \024\f\021\034\033 )Tj 0 Tw T* (\n\024\007\036\035\017 \017)Tj /Span<>> BDC ( )Tj EMC (\022\026\004\036\f\021\r\024\n \023\030\024\020\027\024\026.)Tj 0.183 Tw T* [(\210\007\027\026\022\024 )0.5(\027\026\002\035\033\007\026\036\n\026\016 )0.6(\220\235\235\036\022\021\017\r\027\024\f\021\034 )0.6(\021\024\020\024 )0.5(\017\035\017 )0.5(\017\027\024)]TJ 0 Tw (-)Tj 0.104 Tw T* (\020\024 \026\035\020\024\030\017\021\n\026 \n\024\032\036\021 \r\026\030\ \034\017\030\024\r\026\021\034 \023\024\007 \r\035\017\016\027\017\036\n\ \030\026)Tj 0 Tw (-)Tj 0.161 Tw T* [(\035\017\004\027\t\b \n\036\021\024\007\024\035\024\020\017\004\036\f\022\ \017\b )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC (\022\035\017\027\017\004\036\f\022\017\b \235\026\022\021\024\030\024\r,\ )Tj 0.029 Tw T* (\021\026\022\017\b \022\026\022 \030\026\n\036\030 \017)Tj /Span<>> BDC ( )Tj EMC (\030\036\023\030\036\036\027\021\026\021\017\r\027\024\f\021\034 \017\f\ \f\035\036\007\031\036\n\t\b )Tj 0.099 Tw T* (\r\t\002\024\030\024\022, \017\f\023\024\035\034\031\036\n\t\036 \023\024\ \007\b\024\007\t \022)Tj /Span<>> BDC ( )Tj EMC (\r\026\035\017\007\026\006\017\017, \022\026\004\036)Tj 0 Tw (-)Tj -0.032 Tw T* (\f\021\r\024 \017\f\b\024\007\027\t\b \007\026\027\027\t\b \017)Tj /Span<>> BDC ( )Tj EMC (\022\024\035\017\004\036\f\021\r\024 \r\022\035\033\004\201\027\027\t\b \ \022\035\017)Tj 0 Tw (-)Tj 0.251 Tw T* [(\027\017\004\036\f\022\017\b \023\026\030\026\n\036\021\030\024\r. )0.5(\217\026\035\017\004\017\016 \r)]TJ /Span<>> BDC ( )Tj EMC (\b\026\030\026\022\021\036\030\017\f\021\017\022\026\b )Tj -0.022 Tw T* (\n\024\007\036\035\036\005 \n\024\020\031\021 \024\021\030\026\032\026\021\ \034 \027\036 \f\021\024\035\034\022\024 \r\027\031\021\030\036\027\027\017\ \036 \023\030\036\017)Tj 0 Tw (-)Tj -0.034 Tw T* [(\n\031\013\036\f\021\r\026 \024\023\030\036\007\036\035\201\027\027\024\020\ \024 )0.5(\026\035\020\024\030\017\021\n\026, \f\022\024\035\034\022\024 \r\035\017\ \016\027\017\036 )]TJ -0.024 Tw T* [(\023\024\021\036\027\006\017\026\035\034\027\t\b )0.6(\017\f\021\024\004\027\017\022\024\r )0.6(\f\017\f\021\036\n\026\021\017\004\036\f\022\024\005 )0.5(\024\001\017\002\022\017, )]TJ -0.004 Tw T* (\r\022\035\033\004\026\016 \023\031\002\035\017\022\026\006\017\024\027\027\ \024\036 \f\n\036\013\036\027\017\036, \027\036\024\007\027\024\030\024\007\ \027\024\f\021\034 )Tj 0.506 Tw T* [(\022\030\017\021\036\030\017\036\r )0.5(\r\022\035\033\004\036\027\017\016 )0.6(\023\026\006\017\036\027\021\024\r, )0.6(\r\026\030\017\026\002\036\035\034\027\024\f\021\034 )]TJ 0.13 Tw T* (\023\030\024\006\036\007\031\030 \023\024\007\020\024\021\024\r\022\017 \ \007\026\027\027\t\b \017)Tj /Span<>> BDC ( )Tj EMC (\027\036\024\007\017\027\026\022\024\r\t\036 \f\021\030\026)Tj 0 Tw (-)Tj T* (\021\036\020\017\017 \023\024\007\002\024\030\026 \020\017\023\036\030\023\ \026\030\026\n\036\021\030\024\r \n\024\007\036\035\036\005.)Tj 0.343 Tw T* (\210\021\f\031\021\f\021\r\017\036 \036\007\017\027\t\b \022\030\017\021\ \036\030\017\036\r \024\006\036\027\022\017 \017)Tj /Span<>> BDC ( )Tj EMC (\027\036\023\024\035\027\024\036 )Tj 0.227 Tw T* [(\024\023\017\f\026\027\017\036 \023\026\030\026\n\036\021\030\024\r )0.5(\024\002\031\004\036\027\017\016 \f\027\017\032\026\036\021 \r\024\f\023\ \030\024\017)]TJ 0 Tw (-)Tj 0.266 Tw T* (\r\024\007\017\n\024\f\021\034 \017)Tj /Span<>> BDC ( )Tj EMC (\024\020\030\026\027\017\004\017\r\026\036\021 \f\024\023\024\f\021\026\r\ \017\n\024\f\021\034 \030\036\031\035\034)Tj 0 Tw (-)Tj 0.035 Tw 0 -1.218 TD (\021\026\021\024\r. \200\022\035\033\004\201\027\027\t\036 \n\024\007\036\ \035\017 \236\236 \030\026\035\017\004\026\035\017\f\034 \023\024)Tj /Span<>> BDC ( )Tj EMC (\004\017\f\035\031 )Tj 0.051 Tw 0 -1.218 TD (\023\030\036\007\017\022\021\024\030\024\r \(\024\021 7 \007\024)Tj /Span<>> BDC ( )Tj EMC (44\), \004\021\024 \n\024\020\035\024 \021\026\022 \032\036 \023\024\r\035\ \017\016\021\034 )Tj 0.228 Tw 0 -1.218 TD (\027\026)Tj /Span<>> BDC ( )Tj EMC (\f\035\024\032\027\024\f\021\034 \017)Tj /Span<>> BDC ( )Tj EMC (\021\024\004\027\024\f\021\034 \023\030\024\020\027\024\024\r. \003\027\ \026\004\017\021\036\035\034\027\t\036 )Tj 0.018 Tw T* (\030\026\035\017\004\017\016 \024\021\n\036\004\036\027\t \017)Tj /Span<>> BDC ( )Tj EMC (\r \004\017\f\035\036\027\027\024\f\021\017 \r\t\002\024\030\024\022 \(\024\ \021 164 )Tj 0.02 Tw T* (\007\024)Tj /Span<>> BDC ( )Tj EMC (528)Tj /Span<>> BDC ( )Tj EMC (060 \023\026\006\017\036\027\021\024\r\), \017\f\021\024\004\027\017\022\ \026\b \007\026\027\027\t\b \017)Tj /Span<>> BDC ( )Tj EMC (\f\021\026\007\017\016\b )Tj 0.052 Tw T* (\026\002\024\035\036\r\026\027\017\016. \210\007\027\017 \017\f\f\035\036\ \007\024\r\026\027\017\016 \r\022\035\033\004\026\035\017, \023\030\036\017\ \n\031)Tj 0 Tw (-)Tj 0.111 Tw T* (\013\036\f\021\r\036\027\027\024, \023\026\006\017\036\027\021\024\r \027\ \026)Tj /Span<>> BDC ( )Tj EMC (\030\026\027\027\017\b \f\021\026\007\017\016\b, \007\030\031\020\017\036\ )Tj /Span<>> BDC ( )Tj EMC [(\227 )344( )]TJ 0.215 Tw T* (\002\024\035\036\036 \022\035\017\027\017\004\036\f\022\017 \030\026\027\ \024\024\002\030\026\027\t\036 \022\024\020\024\030\021\t. \212\026\027\ \027\024\036 )Tj -0.051 Tw T* [(\023\030\036\007\023\024\035\024\032\036\027\017\036 )0.6(\023\024\007\021\r\036\030\032\007\026\036\021\f\016 )0.6(\030\036\031\035\034\021\026\021\026\n\017 )0.5(\026\027\026\035\017)]TJ 0 Tw (-)Tj -0.009 Tw T* [(\026 \004\031\r\f\021\r\017\021\036\035\034\027\024\f\021\017: )0.5(\017\f\022\035\033\004\036\027\017\036 \002\024\035\034\001\017\027\f\021\ \r\026 \030\026\002\024\021 )]TJ 0.227 Tw T* (\027\036 \024\022\026\t\r\026\035\024 \f\031\013\036\f\021\r\036\027\027\ \024\020\024 \r\035\017\016\027\017\016 \027\026)Tj /Span<>> BDC ( )Tj EMC (\017\021\024\020\024\r\031\033 )Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0 Tw 9 0 0 9 42.5197 730.483 Tm (\020\004\206\f\t\204\004 6.)Tj 0 0 0 1 k /GS1 gs /T1_3 1 Tf ( \214\034\b\016\033\037\007\022\034\020\020\032\004 \037\020\037\027\022\ \031: \036\027\022\030\020\022\016 \037\027\013\034\033\022\035\006\037 \ \200\200 \020\037)Tj /Span<>> BDC ( )Tj EMC [(\036\037\033\022\037)0.5(\025\016\027\003\020\034\024\035\003 AUC)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf -0.027 Tc 0.027 Tw 0 -1.2 TD [(T)0.5(a)-35.3(b)-40.7(l)-38.7(e)-27( 6)-29.5(.)]TJ 0 0 0 1 k /GS1 gs /T1_3 1 Tf 0 Tc 0 Tw 3.329 0 Td [( M)-2(o)-12(d)-5.2(e)-6(r)3.3(a)-9.2(t)-29.1(i)-1.4(o)-4(n a)-5.1(na)-4.5(l)6.7(y)-5.3(s)-12.5(i)6.6(s)10.2(: t)-10.6(h)-2.4(e)]TJ /Span<>> BDC ( )Tj EMC [(ef)-42.4(f)-13.4(e)-10.9(c)-32.4(t o)4(f)]TJ /Span<>> BDC ( )Tj EMC [(t)-10.5(h)-2.4(e a)-4.2(r)-41.9(t)-29.1(i)6.4(\244)-1.2(c)-30.1(i)1.6(a)-4.5(l i)3.9(n)-0.6(t)-1.6(e)-6.1(l)-3.9(li)1.4(g)-6.8(e)-7(n)-2.9(c)2.8(e a)-4.5(lg)-6.8(o)-3(r)-38.9(i)-3.4(t)-10.6(h)0.8(m o)-4(n v)6.3(a)-4.2(r)-38.9(i)1.5(a)-0.9(b)-1.1(i)2.9(li)-3.4(t)-33.8(y A)19(U)2.4(C)]TJ ET 0 0 0 1 K 0.5 w /GS2 gs q 1 0 0 1 42.5197 715.181 cm 0 0 m 76.785 0 l S Q q 1 0 0 1 42.7697 694.3618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 119.3051 715.181 cm 0 0 m 99.213 0 l S Q q 1 0 0 1 119.3051 694.3618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 218.5177 715.181 cm 0 0 m 99.213 0 l S Q q 1 0 0 1 218.5177 694.3618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 317.7303 715.181 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 317.7303 694.3618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 377.2579 715.181 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 377.2579 694.3618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 436.7855 715.181 cm 0 0 m 59.778 0 l S Q q 1 0 0 1 436.7855 694.3618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 496.313 694.3618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 42.5197 694.1118 cm 0 0 m 76.785 0 l S Q q 1 0 0 1 42.7697 682.9005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 119.3051 694.1118 cm 0 0 m 99.213 0 l S Q q 1 0 0 1 119.3051 682.9005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 218.5177 694.1118 cm 0 0 m 99.213 0 l S Q q 1 0 0 1 218.5177 682.9005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 317.7303 694.1118 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 317.7303 682.9005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 377.2579 694.1118 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 377.2579 682.9005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 436.7855 694.1118 cm 0 0 m 59.778 0 l S Q q 1 0 0 1 436.7855 682.9005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 682.9005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 682.6505 cm 0 0 m 76.785 0 l S Q q 1 0 0 1 42.7697 671.4393 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 119.3051 682.6505 cm 0 0 m 99.213 0 l S Q q 1 0 0 1 119.3051 671.4393 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 218.5177 682.6505 cm 0 0 m 99.213 0 l S Q q 1 0 0 1 218.5177 671.4393 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 317.7303 682.6505 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 317.7303 671.4393 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 377.2579 682.6505 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 377.2579 671.4393 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 436.7855 682.6505 cm 0 0 m 59.778 0 l S Q q 1 0 0 1 436.7855 671.4393 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 671.4393 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 671.1893 cm 0 0 m 76.785 0 l S Q q 1 0 0 1 42.7697 659.978 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 119.3051 671.1893 cm 0 0 m 99.213 0 l S Q q 1 0 0 1 119.3051 659.978 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 218.5177 671.1893 cm 0 0 m 99.213 0 l S Q q 1 0 0 1 218.5177 659.978 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 317.7303 671.1893 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 317.7303 659.978 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 377.2579 671.1893 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 377.2579 659.978 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 436.7855 671.1893 cm 0 0 m 59.778 0 l S Q q 1 0 0 1 436.7855 659.978 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 659.978 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 659.728 cm 0 0 m 76.785 0 l S Q q 1 0 0 1 42.7697 648.5167 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 119.3051 659.728 cm 0 0 m 99.213 0 l S Q q 1 0 0 1 119.3051 648.5167 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 218.5177 659.728 cm 0 0 m 99.213 0 l S Q q 1 0 0 1 218.5177 648.5167 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 317.7303 659.728 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 317.7303 648.5167 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 377.2579 659.728 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 377.2579 648.5167 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 436.7855 659.728 cm 0 0 m 59.778 0 l S Q q 1 0 0 1 436.7855 648.5167 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 648.5167 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 648.2667 cm 0 0 m 76.785 0 l S Q q 1 0 0 1 42.7697 637.0554 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 119.3051 648.2667 cm 0 0 m 99.213 0 l S Q q 1 0 0 1 119.3051 637.0554 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 218.5177 648.2667 cm 0 0 m 99.213 0 l S Q q 1 0 0 1 218.5177 637.0554 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 317.7303 648.2667 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 317.7303 637.0554 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 377.2579 648.2667 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 377.2579 637.0554 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 436.7855 648.2667 cm 0 0 m 59.778 0 l S Q q 1 0 0 1 436.7855 637.0554 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 637.0554 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 636.8054 cm 0 0 m 76.785 0 l S Q q 1 0 0 1 42.7697 625.5941 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 119.3051 636.8054 cm 0 0 m 99.213 0 l S Q q 1 0 0 1 119.3051 625.5941 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 218.5177 636.8054 cm 0 0 m 99.213 0 l S Q q 1 0 0 1 218.5177 625.5941 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 317.7303 636.8054 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 317.7303 625.5941 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 377.2579 636.8054 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 377.2579 625.5941 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 436.7855 636.8054 cm 0 0 m 59.778 0 l S Q q 1 0 0 1 436.7855 625.5941 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 625.5941 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 625.3441 cm 0 0 m 76.785 0 l S Q q 1 0 0 1 42.7697 614.1328 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 119.3051 625.3441 cm 0 0 m 99.213 0 l S Q q 1 0 0 1 119.3051 614.1328 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 218.5177 625.3441 cm 0 0 m 99.213 0 l S Q q 1 0 0 1 218.5177 614.1328 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 317.7303 625.3441 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 317.7303 614.1328 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 377.2579 625.3441 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 377.2579 614.1328 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 436.7855 625.3441 cm 0 0 m 59.778 0 l S Q q 1 0 0 1 436.7855 614.1328 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 614.1328 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 613.8828 cm 0 0 m 76.785 0 l S Q q 1 0 0 1 119.3051 613.8828 cm 0 0 m 99.213 0 l S Q q 1 0 0 1 218.5177 613.8828 cm 0 0 m 99.213 0 l S Q q 1 0 0 1 317.7303 613.8828 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 377.2579 613.8828 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 436.7855 613.8828 cm 0 0 m 59.778 0 l S Q BT /GS1 gs /T1_2 1 Tf 8 0 0 8 64.4335 701.7465 Tm (\032\f\n\002\006\t\003\214)Tj 8.739 0 Td (\017\204\r\b\220\004 \(\f\002\n\t\003 AUC\))Tj 12.236 0 Td (\255\003\004\b\240\004\006\003\b\004\235 \002\232\t\206\220\004)Tj 11.764 0.6 Td (\031\034 \(\b\t\202\b\235\235 )Tj 0.655 -1.2 Td (\n\006\004\b\t\204\004\))Tj 6.684 1.2 Td (\031\034 \(\r\006\216\b\235\235 )Tj 0.757 -1.2 Td (\n\006\004\b\t\204\004\))Tj /T1_4 1 Tf 7.849 0.6 Td (p)Tj /T1_2 1 Tf (-value)Tj /T1_1 1 Tf -51.038 -2.033 Td (DT)Tj 14.071 0 Td (0,4097)Tj 12.402 0 Td (0,4097)Tj 9.921 0 Td (1,2377)Tj 7.441 0 Td (2,8436)Tj 7.324 0 Td (<)Tj /Span<>> BDC ( )Tj EMC (0,001)Tj -51.159 -1.433 Td (GB)Tj 14.071 0 Td (0,5974)Tj 12.402 0 Td (0,5974)Tj 9.671 0 Td (\2311,1207)Tj 7.691 0 Td (1,2209)Tj 7.691 0 Td (0,273)Tj -51.526 -1.433 Td (LightGBM)Tj 14.071 0 Td (0,4581)Tj 12.402 0 Td (0,5854)Tj 9.671 0 Td (\2311,2481)Tj 7.691 0 Td (2,1643)Tj 7.691 0 Td (0,289)Tj -51.526 -1.433 Td (LR)Tj 14.071 0 Td (0,9487)Tj 12.402 0 Td (0,5987)Tj 9.671 0 Td (\2310,1986)Tj 7.691 0 Td (2,0961)Tj 7.691 0 Td (0,118)Tj -51.526 -1.433 Td (NB)Tj 13.821 0 Td (\2311,5719)Tj 12.652 0 Td (0,5719)Tj 9.671 0 Td (\2312,3143)Tj 7.441 0 Td (\2310,0724)Tj 7.941 0 Td (0,034)Tj -51.526 -1.433 Td (SSLR)Tj 13.821 0 Td (\2310,9148)Tj 12.652 0 Td (0,4585)Tj 9.671 0 Td (\2311,8125)Tj 7.691 0 Td (\2310,017)Tj 7.691 0 Td (0,049)Tj -51.526 -1.433 Td (XGBoost)Tj 14.071 0 Td (0,4847)Tj 12.402 0 Td (0,4847)Tj 9.671 0 Td (\2310,7026)Tj 7.691 0 Td (1,1974)Tj 7.691 0 Td (0,609)Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\007\003\032)50(\n\n\217\n)-21(\035\030\002)]TJ 53.418 0 Td [(MET)30(A)-41(-)-41.9(ANAL)30(Y)30(SIS)]TJ /T1_5 1 Tf 25 0 0 25 505.4271 56.0378 Tm (135)Tj ET endstream endobj 1502 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.065 Tw 10 0 0 10 70.8661 566.5159 Tm (\022\024\035\017\004\036\f\021\r\036\027\027\024\020\024 \023\024\007\021\ \r\036\030\032\007\036\027\017\016. \212\035\016 \024\006\036\027\022\017\ \031\f\021\024\005)Tj 0 Tw (-)Tj 0.038 Tw 0 -1.218 TD (\004\017\r\024\f\021\017 \030\036\031\035\034\021\026\021\024\r \n\036\021\ \026\026\027\026\035\017\026 \002\t\035 \023\030\024\r\036\007\201\027 \ \026\027\026)Tj 0 Tw (-)Tj 0.097 Tw T* (\035\017 \004\031\r\f\021\r\017\021\036\035\034\027\024\f\021\017 \f)Tj /Span<>> BDC ( )Tj EMC (\023\024\f\035\036\007\024\r\026\021\036\035\034\027\t\n \017\f\022\035\033\ \004\036)Tj 0 Tw (-)Tj 0.032 Tw T* [(\027\017\036\n \022\026\032\007\024\020\024 \017\f\f\035\036\007\024\r\026\ \027\017\016 \(leave-one-out anal)35(y)-13(sis\), )]TJ 0 Tw T* (\(\217\017\f.)Tj /Span<>> BDC ( )Tj EMC (4\).)Tj 0.577 Tw T* (\211\007\026\035\036\027\017\036 \002\024\035\034\001\017\027\f\021\r\026\ \017\f\f\035\036\007\024\r\026\027\017\005 \027\036 \023\030\017\r\036)Tj 0 Tw (-)Tj 0.566 Tw T* (\035\024 \022)Tj /Span<>> BDC ( )Tj EMC [(\f\031\013\036\f\021\r\036\027\027\t\n \017\n\036\027\036\027\017\016\n\ \017\021\024\020\024\r\024\005 A)17(UC. )]TJ -0.005 Tw T* [(\203\026\017\002\024\035\034\001\036\036 \f\027\017\032\036\027\017\036 \ A)17.1(UC \(\007\024 0,849\) \017)]TJ /Span<>> BDC ( )Tj EMC (\f\027\017\032\036\027\017\036 \020\036)Tj 0 Tw (-)Tj -0.02 Tw T* [(\021\036\030\024\020\036\027\027\024\f\021\017 )0.6(\(\007\024 )0.5(94%\) )0.5(\027\026\002\035\033\007\026\035\024\f\034 )0.5(\023\030\017)]TJ /Span<>> BDC ( )Tj EMC 17.06 0 Td (\017\f\022\035\033\004\036\027\017\017 )Tj 0.069 Tw -17.06 -1.218 Td [(\017\f\f\035\036\007\024\r\026\027\017\016 R)11(odr)-37(iguez e)-12(t al., 2023)]TJ /Span<>> BDC ( )Tj EMC [(\227 X)16(GBo)-15.9(ost. \212\035\016 )]TJ 0.177 Tw T* (\024\006\036\027\022\017 \r\035\017\016\027\017\016 \021\017\023\026 \026\ \035\020\024\030\017\021\n\026 \027\026)Tj /Span<>> BDC ( )Tj EMC (\r\026\030\017\026\002\036\035\034\027\024\f\021\034 )Tj 0.002 Tw T* (\024\002\255\036\007\017\027\201\027\027\t\b \024\006\036\027\024\022 \002\ \t\035 \023\030\024\r\036\007\201\027 \n\024\007\036\030\026\006\017\024\ \027\027\t\005 )Tj 0.022 Tw T* (\026\027\026\035\017. \200)Tj /Span<>> BDC ( )Tj EMC (\022\026\004\036\f\021\r\036 \n\024\007\036\030\026\021\024\030\026 \017\ \f\023\024\035\034\024\r\026\035\026\f\034 \022\026\021\036)Tj 0 Tw (-)Tj -0.048 Tw T* (\020\024\030\017\026\035\034\027\026\016 \023\036\030\036\n\036\027\027\026\ \016)Tj /Span<>> BDC ( )Tj EMC (\227 \021\017\023 \026\035\020\024\030\017\021\n\026. \217\036\031\035\034\ \021\026\021\t )Tj 0 Tw T* (\023\030\036\007\f\021\026\r\035\036\027\t \r)Tj /Span<>> BDC ( )Tj EMC (\021\026\002\035\017\006\036 6.)Tj 0.07 Tw T* [(\202\035\020\024\030\017\021\n\t )0.6(D)12(T )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 6.916 0 Td [(LR )0.5(\023\030\024\007\036\n\024\027\f\021\030\017\030\024\r\026\035\017 )0.5(\f\021\026\021\017\f\021\017\004\036)]TJ 0 Tw (-)Tj 0.185 Tw -6.916 -1.218 Td (\f\022\017 \027\026\004\017\n\024\036 \023\024\035\024\032\017\021\036\035\ \034\027\024\036 \r\035\017\016\027\017\036 \027\026)Tj /Span<>> BDC ( )Tj EMC (\017\021\024\020\024\r\t\005 )Tj 0.071 Tw 23.244 35.316 Td [(A)17(UC \()]TJ /T1_1 1 Tf 0 Tw (p)Tj /T1_0 1 Tf 0.071 Tw /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (0,001\), \r)Tj /Span<>> BDC ( )Tj EMC (\021\024 \032\036 \r\030\036\n\016, \026\035\020\024\030\017\021\n\t NB \ \017)Tj /Span<>> BDC ( )Tj EMC [(S)17(SLR )]TJ 0.308 Tw T* [(\002\t\035\017 )0.5(\f\r\016\026\027\t )0.6(\f\024 )0.5(\f\021\026\021\017\f\021\017\004\036\f\022\017 )0.5(\027\026\004\017\n\t\n )0.6(\f\027\017\032\036)]TJ 0 Tw (-)Tj 0.345 Tw T* [(\027\017\036\n A)17(UC \023\024)]TJ /Span<>> BDC ( )Tj EMC (\f\030\026\r\027\036\027\017\033 \f)Tj /Span<>> BDC ( )Tj EMC (\024\f\021\026\035\034\027\t\n\017 \n\024\007\036\035\016\n\017 )Tj 0 Tw T* (\()Tj /T1_1 1 Tf (p)Tj /T1_0 1 Tf 0.121 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,034 \017)Tj /Span<>> BDC ( )Tj EMC /T1_1 1 Tf 0 Tw (p)Tj /T1_0 1 Tf 0.121 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,049, \f\024\024\021\r\036\021\f\021\r\036\027\027\024\). \210\002\013\017\ \005 \021\036\f\021 )Tj 0.13 Tw T* (\n\024\007\036\030\026\021\024\030\024\r \024\022\026\026\035\f\016 \f\021\ \026\021\017\f\021\017\004\036\f\022\017 \027\026\004\017\n\t\n \(QM )Tj 0 Tw T* (\(df)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (7\))Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (15,87, )Tj /T1_1 1 Tf (p)Tj /T1_0 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,026\).)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 303.3769 627.4059 Tm [(\037\036)10(\032\223\212\226\034\022\031\034)]TJ 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.016 Tc 0.652 Tw 10 0 0 10 303.3071 603.0499 Tm [(\215\030\024\r\036\007\201\027\027\t\005 \n\036\021\026\026\027\026\035\017\  \023\024\007\021\r\036\030\007\017\035 \r\t\f\024\022\031\033)16( )]TJ 0.356 Tw T* [(\023\030\024\020\027\024\f\021\017\004\036\f\022\031\033 )0.5(\220\235\235\036\022\021\017\r\027\024\f\021\034 )0.5(\026\035\020\024\030\017\021\n\024\r )0.5(\n\026)]TJ 0 Tc 0 Tw (-)Tj 0.016 Tc 0.229 Tw T* (\001\017\027\027\024\020\024 \024\002\031\004\036\027\017\016 \r)Tj /Span<>> BDC ( )Tj EMC [(\026\007\026\004\036 \023\030\036\007\f\022\026\026\027\017\016 \024\002\ \013\036\005)16( )]TJ 0.165 Tw 0 -1.218 TD [(\r\t\032\017\r\026\036\n\024\f\021\017 )0.6(\031)]TJ /Span<>> BDC ( )Tj EMC 7.556 0 Td [(\023\026\006\017\036\027\021\024\r )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC 5.746 0 Td [(\022\024\035\024\030\036\022\021\026\035\034\027\t\n )0.5(\030\026)]TJ 0 Tc 0 Tw (-)Tj 0.016 Tc 0.224 Tw -13.302 -1.218 Td [(\022\024\n. \210\002\255\036\007\017\027\201\027\027\024\036 \027\026\004\ \036\027\017\036 A)17(UC \f\024\f\021\026\r\017\035\024 0,86)16( )]TJ 0.285 Tw T* [(\(95% \212\236: 0,82\2260,89\), \004\021\024 \f\024\024\021\r\036\021\f\021\ \r\031\036\021 \b\024\030\024\001\036\005)16( )]TJ 0.276 Tw 0 -1.218 TD [(\007\017\f\022\030\017\n\017\027\026\021\017\r\027\024\005 )0.5(\f\023\024\f\024\002\027\024\f\021\017 )0.6(\n\024\007\036\035\036\005. )0.5(\210\007\027\026\022\024)16( )]TJ 0.508 Tw 0 -1.218 TD [(\r\t\f\024\022\026\016 )0.5(\020\036\021\036\030\024\020\036\027\027\024\f\021\034 )0.5(\n\036\032\007\031 )0.5(\017\f\f\035\036\007\024\r\026\027\017\016\n\017)16( )]TJ 0.099 Tw 0 -1.218 TD (\(I\262)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (97,6%\) \024\020\030\026\027\017\004\017\r\026\036\021 \024\002\024\002\013\ \026\036\n\024\f\021\034 \023\024\035\031\004\036\027)Tj 0 Tc 0 Tw (-)Tj 0.016 Tc 0.039 Tw 0 -1.218 TD (\027\t\b \030\036\031\035\034\021\026\021\024\r. \200\036\030\024\016\021\ \027\t\n\017 \017\f\021\024\004\027\017\022\026\n\017 \020\036\021\036\030\ \024)Tj 0 Tc 0 Tw (-)Tj 0.016 Tc 0.016 Tw T* [(\020\036\027\027\024\f\021\017 \016\r\035\016\033\021\f\016 \022\026\022\ \n\036\021\024\007\024\035\024\020\017\004\036\f\022\017\036 \030\026\035\ \017\004\017\016)16( )]TJ 0.175 Tw 0 -1.218 TD (\n\036\032\007\031 \017\f\f\035\036\007\024\r\026\027\017\016\n\017 \(\023\ \024\007\b\024\007 \022)Tj /Span<>> BDC ( )Tj EMC (\024\021\002\024\030\031 \023\030\017\027\026)Tj 0 Tc 0 Tw (-)Tj 0.016 Tc -0.032 Tw 0 -1.218 TD [(\022\024\r, )0.5(\004\017\f\035\036\027\027\024\f\021\034 )0.5(\r\t\002\024\030\024\022, )0.5(\n\036\021\024\007\t )0.5(\r\026\035\017\007\026\006\017\017 )0.5(\n\024\007\036)]TJ 0 Tc 0 Tw (-)Tj 0.016 Tc 0.097 Tw 0 -1.218 TD (\035\036\005\), \021\026\022 \017)Tj /Span<>> BDC ( )Tj EMC (\022\035\017\027\017\004\036\f\022\026\016 \027\036\024\007\027\024\030\024\ \007\027\024\f\021\034 \r\022\035\033\004\201\027)Tj 0 Tc 0 Tw (-)Tj 0.016 Tc 0.181 Tw 0 -1.218 TD [(\027\t\b )0.5(\023\026\006\017\036\027\021\024\r \023\024)]TJ /Span<>> BDC ( )Tj EMC 8.407 0 Td (\f\021\026\007\017\016\n \026\002\024\035\036\r\026\027\017\016 \017)Tj /Span<>> BDC ( )Tj EMC [(\007\030\031\020\017\n)16( )]TJ 0.218 Tw -8.407 -1.218 Td (\b\026\030\026\022\021\036\030\017\f\021\017\022\026\n. \230\026\022\017\ \n \024\002\030\026\024\n, \r)Tj /Span<>> BDC ( )Tj EMC (\031\f\035\024\r\017\016\b \r\t)Tj 0 Tc 0 Tw (-)Tj 0.016 Tc 0.206 Tw 0 -1.218 TD (\030\026\032\036\027\027\024\005 \n\036\021\024\007\024\035\024\020\017\004\ \036\f\022\024\005 \017)Tj /Span<>> BDC ( )Tj EMC (\022\035\017\027\017\004\036\f\022\024\005 \020\036\021\036)Tj 0 Tc 0 Tw (-)Tj 0.016 Tc 0.184 Tw 0 -1.218 TD (\030\024\020\036\027\027\024\f\021\017 \035\033\002\t\036 \023\030\016\n\ \t\036 \f\024\023\024\f\021\026\r\035\036\027\017\016 \220\235\235\036\022\ )Tj 0 Tc 0 Tw (-)Tj 0.016 Tc 0.163 Tw 0 -1.218 TD [(\021\017\r\027\024\f\021\017 \026\035\020\024\030\017\021\n\024\r \n\024\ \020\031\021 \002\t\021\034 \n\036\021\024\007\024\035\024\020\017\004\036\ \f\022\017)16( )]TJ -0.016 Tw 0 -1.218 TD (\027\036\024\002\024\f\027\024\r\026\027\027\t\n\017.)Tj ET q 70.866 612.493 221.102 123.875 re W n q /GS0 gs 221.1023475 0 0 123.8749396 70.8661351 612.4935745 cm /Im0 Do Q Q BT 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0 Tc 0 Tw 9 0 0 9 70.8661 601.6719 Tm (\022\t\217\210\b\002\220 3.)Tj 0 0 0 1 k /GS1 gs /T1_1 1 Tf ( \223\033\037\017\022\021 Funnel plot)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0 -1.2 TD [(F)-16(igure 3.)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf ( Graph of)Tj /Span<>> BDC ( )Tj EMC [(F)24.1(unnel plo)13(t)]TJ ET q /GS0 gs 396.850395 0 0 223.138372 70.8661652 133.4774117 cm /Im1 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0.095 Tw 9 0 0 9 70.8661 122.5701 Tm (\022\t\217\210\b\002\220 4.)Tj 0 0 0 1 k /GS1 gs /T1_1 1 Tf ( \205\020\037\027\022\031 \005\023\036\024\035\036\022\035\016\027\003\020\ \034\024\035\022: \036\027\022\030\020\022\016 \022\024\021\027\026\005\016\ \020\022\030 \034\035\b\016\027\003\020\032\002 \022\024\024\027\016\b\034\ \036\037\020\022\004 \020\037)Tj /Span<>> BDC ( )Tj EMC (\034\025\206\016\b\022\020\246\020\020\023\026 AUC \022)Tj /Span<>> BDC ( )Tj EMC (\013\016\035\016\033\034)Tj 0 Tw (-)Tj 0.063 Tw 0 -1.2 TD [(\013\016\020\020\034\024\035\003 )0.5(\(I\262\) )0.5(\f\033\022)]TJ /Span<>> BDC ( )Tj EMC [(\f\034\034\005\016\033\016\b\020\034\006 )0.5(\022\024\021\027\026\005\016\020\022\022 )0.5(\034\035\b\016\027\003\020\032\002 )0.5(\f\023\025\027\022\021\037\007\022\004. \207\022\020\030\030 \027\022\020\ \022\030)]TJ /Span<>> BDC ( )Tj EMC [(\227 \034\025\206\016\b\022\020\246\020\020\037\030 )0.5(\034\007\016\020\021\037 AUC. \r\033\037\024\020\037\030 )]TJ 0 Tw T* (\f\023\020\021\035\022\033\020\037\030 \027\022\020\022\030)Tj /Span<>> BDC ( )Tj EMC (\227 \023\033\034\036\016\020\003 \013\016\035\016\033\034\013\016\020\020\ \034\024\035\022 I\262)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0.059 Tw T* [(F)-16(igure )0.6(4.)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf [( )0.5(Sensitivity )0.5(analysis: )0.5(the)]TJ /Span<>> BDC ( )Tj EMC 13.775 0 Td [(ef)-40(fect )0.6(of)]TJ /Span<>> BDC ( )Tj EMC 3.665 0 Td [(e)-15(xclusion )0.6(of)]TJ /Span<>> BDC ( )Tj EMC 5.003 0 Td [(individual )0.6(studies )0.5(on )0.6(combined )0.6(A)29(UC )0.5(and )0.6(heterog)12(eneity )0.6(\(I2\) )0.5(when )0.6(indi)]TJ 0 Tw (-)Tj -22.443 -1.2 Td [(vidual publications are e)-14.8(xcluded in tur)-13.8(n. The)]TJ /Span<>> BDC ( )Tj EMC (blue line is the)Tj /Span<>> BDC ( )Tj EMC [(combined A)29.3(UC score. The)]TJ /Span<>> BDC ( )Tj EMC [(red do)13(tted line is the)]TJ /Span<>> BDC ( )Tj EMC [(heterog)12(eneity lev)13(el I2)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\007\003\032)50(\n\n\217\n)-21(\035\030\002)]TJ 53.418 0 Td [(MET)30(A)-41(-)-41.9(ANAL)30(Y)30(SIS)]TJ -53.418 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 2)69(4, \023\0224, 202)23(5)]TJ 43.013 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 2)69(4, \023\0224, 202)23(5)]TJ /T1_5 1 Tf 25 0 0 25 20.8402 56.0378 Tm (134)Tj ET endstream endobj 1503 0 obj <>stream AdobedC     '$''''$25552;;;;;;;;;;:   {!1AS"QRTabq3 #2$%&'()*456789:BCDEFGHIJUVWXYZcdefghijrstuvwxyz?B!,mUaY@G 2!](f{r4v% ZXTMEdF.u("Цd5 {iqv닶( y˄ScpBٲ'} m;Cda]x.uhZ,Gh5depa8x_dN5mU ;"!ҒZr6-CS[gS+i,mGQE}=MtMe״!hS3-@&@ξo#J({骝 eB֌ >زm1#*=a`ӧ 7hXGB-LＶ(fI pkcUV>Φ;XFháͽ +m%k+`qҁ# %jZ"+tuc-],r4Lȯ b ^r4U0Q 㕍 \VD!ЪB!%Ͱ-Z,u- I \_6i{*u-m$"97(dx!nMs]MvYhQ  kň^su&ŭ ';^ VU7L2o3ilVڒe+ò8k⁙!o7qBv-yڹ⤫U6t:\ ϛ'iI@- :(+J6p7|K:ͳmYlMShVYj_Q;1n.65eXeZv; %#2O\\2848BAb~lR(-S99M;j028I 7ܘvXEmlj dD'vNε-RIL8i!fRWE$]%p-;Oc}3r6)_dINl{Y$Þ[;UΧdc&c \M~k˯ ݑe[$[̨}=j"%sߥ@v9I=QOę9&lck.X6[_fTD)+d1EI,bXk[a!u:JblWd4rziZ5 2K pv k\uc 6d4LqU!7& 9ǘflkdնuhDZfŴ"0JG]P|zXvB2ec˷oT#+.ިFV>]P|zXvBU t&"渱{sOLYꅧ=cWCit tƓ9+s+.ިFV>]P|zXvB2ec˷:k !Ɲɿ7љz˷oT#+.ިFV>]P|zXvB2ec˷oT#+.ި^^`ayc눼g0>eq6nzoT#+.ިFV>]P|zXvB2ec T4UzhZKec˷oT I7zaz@Ҫ YjU}G(显V^ Ĝ۹-iIZi-U+%em湷^yb*8|g^z|buօU,T@扜rML. cI볲FBN]2t:쑐gd;$d$u#!'C :vvHI볲FBN]2t:쑐gd;$d$u#!'C :vvHI볲FBN]2t:쑐gd;$d$u#!'C :vvH0ŀy% e!s,#8=Fc󐓡gd;$d$u#!'C :vvHI볲FBN]2t:쑐gd;$d$u#!'C :vvHI볲FBN]2t:쑐gd;$d$u#!'C :vvHI볲FBN]E W8n@Ӫ FƳm)5\8cpV>He 8suܲVlF(MsߜqbsKn^J\-y T ZHBBZӘvaI U_nOOj1Pb'!B![e&ڛJ#ǵ%s+溋!5@/sq%p&A'ww:B!B!B!gc@ԪB d^C(:U=! |!B!B آn'/ͼ;? < FIk%y&FBak e؜ц%כ޸5Tp_7^|۷„!B!B!Y|C반ժB d^C(:U=!B!B!|`6M/Qla7qy,TMppi7޹;1}E6- 0yn3p/#v b݊`H\̜;˱bg7\:Z!B!B,>C!Lh֪ ]nQYJmitI!^]zfB$TSl15kF;J\-y T ZHB!B!BeѶC,'Zo'(o:໨X&1ፃ768o7ɽe\kZ8jETH\1 f֜7oˡ_#*OtI˚ sC# ѹzQ,Xif>q ۢBZU]DkjSKjZ7^1ýcpgX#;<u1ýcpgX#;<u1ýcpgX#;<u1ýcpgX#;<u1ýcpgX${C`{,u,m+c]n 'nޞ1ýcqnDO8Ol]2Ctf)h.-!bnhdž6 8ۀIG& ^p-^q`q/͟Wg;u$8Fc{:ǁη#;<u1ýcpgX#;<u1ýx#;<u1ýcpgX#;<u1ýcpgX#;<uD\@2\q_}Ѫ:'aq(z}3dQI<V9ѴH{[{K >r2Ԭek2U11QO!{X/#93s͓XSQ><./C0:2.3H]%OpŤ! &3WٕmZh Ŏ{CY nϜB!B.FfTN2 Ns\ޒ!X&1nmqo#zʄ.UF|D 7w\ \!B!B!gc@Ҫ;3NNi,l,MM=,#)T!0\ 3'_cY-d8cpV9(]~,6u!ys@Kn9+epE2S1i!A/\A\+#a5h>ңHp89f8xtfNeB!BLx݅ .滓Lq,7CZ.^Є,TMp763yM*ֽp!91/WRJlt^/ZB!B!Y|C반ӤuΡe9kduWa.OEgFkYUlMn|. 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Z骜8щuUij^h{R§ELJUxr;)h&\:qVtRNvj['X/UTຖXiURXM~QrEq1q?5N *n SRuO7sҨUJMMm,jF~ A1>=UMr|:KQba1*T@sMN8*JjP멧fϴuc6?% 1p88UQ]tq7lJ9g#r ^Q]T [OTUCix0.<%Vңe$MI)>i97.O?SإT0Ҧiڅ='׵@F6-NIf7(ƫqj^nNVNrt }j97*弋E,W1TtRT4[?Yi_/Xa~OQ\bm*jYy>7xӇ xi|n_t-Z_c0q<U0*c[Į%m5 ,zO&&>/%mҹG%Uxc=])*njT=@4xKim**TU$30ފr.Oȩ䜥br46-|#*rDz9lJtR٩ڄIB'*^Q_>`Թm>bUZ9q&TBOrC9O!\r>_īKDW}ۧeM^r8'V$:1;[/o.ľWڃoDUuMNjkXE)$VnOѵ@l1611ifZ6r}Eo"ar$I>ojK|NAh圢%jN,'.k z;6T.bE VۺnXsQ׉FMaJ."^oRo9M\ZiLF%*4OF\-[TѷRoj0,K}ˇlzl1ҝ8t[rxmKeRfC X)&{UJt:ژwYQS֩nTY>7-g GkڪU1V%Jc8yM3caL7F;XtSzSI}F܃D^SM.뮥EQNuWSH2o$ lJ10:֩)ʩFY^Kz[5{rji>%uUu9)vXsMtU9sR{e9W(ׁRkħcaiq=>ʨҪ9f]>stream endstream endobj 1506 0 obj <>stream endstream endobj 1500 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\030\b\017\200\b\b)-9.9(\026\r\016\215\215\220\207 \021\215\026)11.1(\016\t\t\016\017)-10(\026 \211)-20.9(\t\004 \222\201\025\202\215\025)21(\213\021\201\025\r\001\215\021\004 )]TJ 0 -1 TD [(\025\026)11(\211\001\t\016\215\215\220 \201\016\213)21(\200\t\214)21(\026)11(\001\026)11(\025\r \t\016\f\016\215\021\004 \235\025\t\214\215\220 \017)10(\025\t\025\201\016\017)-9.9(\026)11(\001\t\214\215\220\024 )]TJ T* [(\201\001\017)10(\025\024 \(\b\021\b)-10(\026)11(\016\024\001\026\021\f\016\b\017\021\207 \025\235\213\025\201 \021\022\024\ \016\026)11(\001\001\215\001\t\021\213\))]TJ 34.456 2 Td [(Ar)-20(tif)-21(icial intelligence for pr)31(edicting long-term outcomes in patients )]TJ 1.361 -1 Td [(with color)31(ectal cancer \(a\022s)10(y)10(stematic r)31(e)11(vie)11(w and meta-analy)10(sis\))]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0.247 Tw 10 0 0 10 42.5197 359.4899 Tm (\023\030\024\020\027\024\017\030\024\r\026\035\026\f\034 \024\002\013\026\ \016 \r\t\032\017\r\026\036\n\024\f\021\034. \200)Tj /Span<>> BDC ( )Tj EMC (\022\026\032\007\024\n )Tj 0.108 Tw 0 -1.218 TD (\017)Tj /Span<>> BDC ( )Tj EMC (\022\024\021\024\030\t\b \002\t\035\026 \r\t\002\030\026\027\026 \n\024\007\ \036\035\034 \f)Tj /Span<>> BDC ( )Tj EMC (\027\026\017\035\031\004\001\017\n \027\026)Tj 0 Tw (-)Tj 0.263 Tw T* [(\004\036\027\017\036\n A)17(UC. \203\026)]TJ /Span<>> BDC ( )Tj EMC [(\035\036\f\024\r\017\007\027\024\n \020\030\026\235\017\022\036 \(F)10(or)-23.9(est pl)30.1(o)17(t\) )]TJ 0.221 Tw T* [(\023\030\036\007\f\021\026\r\035\036\027\t \024\006\036\027\022\017 A)17(UC \017)]TJ /Span<>> BDC ( )Tj EMC (\f\024\024\021\r\036\021\f\021\r\031\033\013\017\036 95% )Tj 0.077 Tw T* [(\007\024\r\036\030\017\021\036\035\034\027\t\036 )0.5(\017\027\021\036\030\r\026\035\t \023\024)]TJ /Span<>> BDC ( )Tj EMC (\022\026\032\007\024\n\031 \r\022\035\033\004\201\027\027\024\n\031 )Tj 0 Tw T* (\017\f\f\035\036\007\024\r\026\027\017\033 \(\217\017\f.)Tj /Span<>> BDC ( )Tj EMC (2\).)Tj -0.026 Tw T* [(\203\026\017\002\024\035\034\001\036\036 \027\026\004\036\027\017\036 A\ )17(UC \002\t\035\024 \026\235\017\022\f\017\030\024\r\026\027\024 \r)]TJ /Span<>> BDC ( )Tj EMC (\017\f)Tj 0 Tw (-)Tj 0.102 Tw T* [(\f\035\036\007\024\r\026\027\017\017 )0.5(R)11(odr)-37(iguez e)-11.9(t al. \(2023\) )0.5(\023\030\017)]TJ /Span<>> BDC ( )Tj EMC (\023\030\017\n\036\027\036\027\017\017 )Tj -0.016 Tw T* [(\026\035\020\024\030\017\021\n\026 X)16(GBo)-15.9(ost \(0,94\) [17]. \203\026\017\n\036\027\034\001\036\036 \027\026\004\036\ \027\017\036 )]TJ 0.087 Tw 23.244 9.742 Td [(A)17(UC \002\t\035\024 \023\030\036\007\f\021\026\r\035\036\027\024 \r)]TJ /Span<>> BDC ( )Tj EMC [(\017\f\f\035\036\007\024\r\026\027\017\017 M)-23.9(ohammadi )]TJ -0.023 Tw T* [(e)-12(t al. \(2024\) )]TJ /Span<>> BDC ( )Tj EMC (\227 NB \(0,70\) [41]. \210\002\024\002\013\201\027\027\024\036 \027\026\ \004\036\027\017\036 )Tj -0.002 Tw T* [(A)17(UC \f\024\f\021\026\r\017\035\024 0,86 \(95% \212\236: 0,82\2260,89\). \212\ \035\016 \022\024\035\017\004\036)]TJ 0 Tw (-)Tj 0.028 Tw T* (\f\021\r\036\027\027\024\005 \024\006\036\027\022\017 \r\026\030\017\026\ \002\036\035\034\027\024\f\021\017 \n\036\032\007\031 \r\022\035\033\004\ \201\027\027\t)Tj 0 Tw (-)Tj 0.049 Tw T* (\n\017 \017\f\f\035\036\007\024\r\026\027\017\016\n\017 \002\t\035 \023\030\ \024\r\036\007\201\027 \026\027\026\035\017 \020\036\021\036\030\024\020\ \036\027)Tj 0 Tw (-)Tj T* (\027\024\f\021\017 \(\230\026\002\035.)Tj /Span<>> BDC ( )Tj EMC (5\).)Tj 0.437 Tw T* (\202\027\026\035\017 \020\036\021\036\030\024\020\036\027\027\024\f\021\ \017 \023\024\022\026\026\035 \r\t\f\024\022\031\033 \f\021\036\023\036\ \027\034 )Tj 0.585 Tw T* (\r\026\030\017\026\002\036\035\034\027\024\f\021\017 \n\036\032\007\031 \ \r\022\035\033\004\201\027\027\t\n\017 \017\f\f\035\036\007\024\r\026)Tj 0 Tw (-)Tj 0.257 Tw T* (\027\017\016\n\017. \003\027\026\004\036\027\017\036 I\262)Tj /Span<>> BDC ( )Tj EMC (\227 97,6%, \031\022\026\t\r\026\036\021 \027\026)Tj /Span<>> BDC ( )Tj EMC (\r\t\030\026)Tj 0 Tw (-)Tj 1.019 Tw T* (\032\036\027\027\031\033 \n\036\032\017\f\f\035\036\007\024\r\026\021\036\ \035\034\f\022\031\033 \020\036\021\036\030\024\020\036\027\027\024\f\021\ \034. )Tj -0.025 Tw T* [(\025\030\017\021\036\030\017\005 )0.6(\025\024\022\030\026\027\026 )0.5(Q)]TJ /Span<>> BDC ( )Tj EMC 8.601 0 Td (=)Tj /Span<>> BDC ( )Tj EMC 0.707 0 Td (669,03, )Tj /T1_2 1 Tf 0 Tw 3.077 0 Td (p)Tj /T1_1 1 Tf -0.025 Tw /Span<>> BDC ( )Tj EMC 0.685 0 Td (<)Tj /Span<>> BDC ( )Tj EMC 0.707 0 Td [(0,001, )0.5(\004\021\024 )0.6(\031\022\026\t\r\026\036\021 )]TJ 0.33 Tw -13.779 -1.218 Td (\027\026)Tj /Span<>> BDC ( )Tj EMC (\f\021\026\021\017\f\021\017\004\036\f\022\017 \027\026\004\017\n\031\033\ \020\036\021\036\030\024\020\036\027\027\024\f\021\034 \n\036\032\007\031\ )Tj 0.243 Tw T* (\017\f\f\035\036\007\024\r\026\027\017\016\n\017, \030\036\031\035\034\021\ \026\021 \266\262)Tj /Span<>> BDC ( )Tj EMC (\227 0,289 \007\036\n\024\027\f\021\030\017)Tj 0 Tw (-)Tj 0.545 Tw T* (\030\031\036\021 \r\026\030\017\026\002\036\035\034\027\024\f\021\034 \017\ \f\021\017\027\027\t\b \220\235\235\036\022\021\024\r \n\036\032\007\031\ )Tj 0 Tw T* (\017\f\f\035\036\007\024\r\026\027\017\016\n\017.)Tj 0.468 Tw T* (\210\006\036\027\022\026 \023\031\002\035\017\022\026\006\017\024\027\027\ \024\020\024 \f\n\036\013\036\027\017\016 \023\030\036\007\f\021\026\r\035\ \036\027\026 )Tj 0.271 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC [(\r\024\030\024\027\022\024\024\002\030\026\027\024\005 \007\017\026\020\ \030\026\n\n\036 \(funnel pl)30(o)17(t\), \024\021\024)]TJ 0 Tw (-)Tj 0.443 Tw T* (\002\030\026\032\026\033\013\036\005 \r\026\017\n\024\f\r\016\034 \n\036\ \032\007\031 \035\024\020\017\021-\023\030\036\024\002\030\026\024)Tj 0 Tw (-)Tj 0.035 Tw T* [(\r\026\027\027\t\n\017 \027\026\004\036\027\017\016\n\017 A)17(UC \017)]TJ /Span<>> BDC ( )Tj EMC (\017\b \f\021\026\027\007\026\030\021\027\024\005 \024\001\017\002\022\024\ \005 )Tj 0 Tw T* (\(\217\017\f.)Tj /Span<>> BDC ( )Tj EMC (3\).)Tj 0.004 Tw T* (\203\026 \020\030\026\235\017\022\036 \027\026\002\035\033\007\026\036\021\ \f\016 \031\n\036\030\036\027\027\026\016 \026\f\017\n\n\036\021\030\017\ \016 \030\026\f)Tj 0 Tw (-)Tj 0.174 Tw T* (\023\030\036\007\036\035\036\027\017\016 \021\024\004\036\022 \r)Tj /Span<>> BDC ( )Tj EMC (\f\021\024\030\024\027\031 \023\024\035\024\032\017\021\036\035\034\027\t\ \b \027\026\004\036)Tj 0 Tw (-)Tj 0.015 Tw T* (\027\017\005 \220\235\235\036\022\021\026. \200\017\031\026\035\034\027\ \026\016 \017\027\021\036\030\023\030\036\021\026\006\017\016 \023\030\024\ \r\024\007\017\021\f\016 )Tj 0.072 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC (\024\f\027\024\r\036 \f\017\n\n\036\021\030\017\004\027\024\f\021\017 \030\ \026\f\023\030\036\007\036\035\036\027\017\016 \017)Tj /Span<>> BDC ( )Tj EMC (\021\030\036\002\031\036\021 )Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0 Tw 9 0 0 9 42.5197 730.483 Tm (\020\004\206\f\t\204\004 3.)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf ( \212\037\033\037\021\035\016\033\022\024\035\022\021\022 \022)Tj /Span<>> BDC ( )Tj EMC (\035\022\f\032 \b\037\020\020\032\002 \036)Tj /Span<>> BDC ( )Tj EMC [(\033\037\024\024\006\037\035\033\022\036\037\016\006\032\002 \024\035\037\ \035\003)0.5(\030\002 \(N)]TJ /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (43 \022\024\024\027\016\b\034\036\037\020\022\004\))Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf -0.027 Tc 0.027 Tw 0 -1.2 TD [(T)0.5(a)-35.3(b)-40.7(l)-38.7(e)-27( 3)-18.8(.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf 0 Tc 0 Tw 3.318 0 Td [( C)-1.1(ha)-4.2(r)3.3(a)-9.1(c)-32.4(t)-1.6(e)-6(r)-39(i)6.6(s)-14.8(t)-29.1(i)-1.8(c)-26.7(s a)-5(n)-4.8(d t)-33.8(y)-11(p)-11.3(e)-22(s o)4(f)]TJ /Span<>> BDC ( )Tj EMC [(d)-2.5(a)-9.2(t)-2(a i)3.9(n t)-10.6(h)-2.4(e)]TJ /Span<>> BDC ( )Tj EMC [(a)-4.2(r)-41.9(t)-29.1(i)-1.8(c)-1.1(le)-22(s \()29.6(N)]TJ /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC [(4)13.7(3)68.4(\))]TJ ET 0 0 0 1 K 0.5 w /GS2 gs q 1 0 0 1 42.5197 715.181 cm 0 0 m 178.833 0 l S Q q 1 0 0 1 42.7697 703.9617 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 221.3524 715.181 cm 0 0 m 121.89 0 l S Q q 1 0 0 1 221.3524 703.9617 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 343.2421 715.181 cm 0 0 m 153.321 0 l S Q q 1 0 0 1 343.2421 703.9617 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 496.313 703.9617 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 42.5197 703.7117 cm 0 0 m 178.833 0 l S Q q 1 0 0 1 42.7697 692.5005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 221.3524 703.7117 cm 0 0 m 121.89 0 l S Q q 1 0 0 1 221.3524 692.5005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 343.2421 703.7117 cm 0 0 m 153.321 0 l S Q q 1 0 0 1 343.2421 692.5005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 692.5005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 692.2505 cm 0 0 m 178.833 0 l S Q q 1 0 0 1 42.7697 681.0392 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 221.3524 692.2505 cm 0 0 m 121.89 0 l S Q q 1 0 0 1 221.3524 681.0392 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 343.2421 692.2505 cm 0 0 m 153.321 0 l S Q q 1 0 0 1 343.2421 681.0392 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 681.0392 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 680.7892 cm 0 0 m 178.833 0 l S Q q 1 0 0 1 42.7697 669.5779 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 221.3524 680.7892 cm 0 0 m 121.89 0 l S Q q 1 0 0 1 221.3524 669.5779 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 343.2421 680.7892 cm 0 0 m 153.321 0 l S Q q 1 0 0 1 343.2421 669.5779 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 669.5779 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 669.3279 cm 0 0 m 178.833 0 l S Q q 1 0 0 1 42.7697 658.1166 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 221.3524 669.3279 cm 0 0 m 121.89 0 l S Q q 1 0 0 1 221.3524 658.1166 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 343.2421 669.3279 cm 0 0 m 153.321 0 l S Q q 1 0 0 1 343.2421 658.1166 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 658.1166 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 657.8666 cm 0 0 m 178.833 0 l S Q q 1 0 0 1 221.3524 657.8666 cm 0 0 m 121.89 0 l S Q q 1 0 0 1 343.2421 657.8666 cm 0 0 m 153.321 0 l S Q BT /GS1 gs /T1_3 1 Tf 8 0 0 8 53.4061 706.5463 Tm (\021\002\f\t\201\r\217\003\002 \220\f\211\201\r\b\b\013\216 )Tj /Span<>> BDC ( )Tj EMC (\004\b\004\f\t\213 \212\006\t\213\b\004\220\002)Tj 22.134 0 Td (\030\t\217\f\002 \t\217\217\f\r\240\002\004\b\t\005 \(N)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (43\))Tj 21.615 0 Td (\034\217\003\002\201\b\t\220)Tj /T1_1 1 Tf -44.725 -1.433 Td (<)Tj /Span<>> BDC ( )Tj EMC (10)Tj 26.907 0 Td (8/43)Tj /Span<>> BDC ( )Tj EMC (\(18,6%\))Tj 16.005 0 Td ([3,6\2268,18,19,32,33])Tj -42.911 -1.433 Td (10\22615)Tj 26.657 0 Td (16/43)Tj /Span<>> BDC ( )Tj EMC (\(39,2%\))Tj 11.922 0 Td ([4,5,9,10,12\22614,16,20,26,29\22631,34,36,39])Tj -38.578 -1.433 Td (16\22620)Tj 26.907 0 Td (9/43)Tj /Span<>> BDC ( )Tj EMC (\(20,9%\))Tj 14.755 0 Td ([1,2,15,17,21,22,28,42,43])Tj -41.662 -1.433 Td (>)Tj /Span<>> BDC ( )Tj EMC (20)Tj 26.657 0 Td (10/43)Tj /Span<>> BDC ( )Tj EMC (\(23,3%\))Tj 14.32 0 Td ([11,23\22625,27,35,37,38,40,41])Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 9 0 0 9 42.5197 641.1473 Tm (\020\004\206\f\t\204\004 4.)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf ( \t\034\021\037\031\037\035\016\027\022 \220\017\017\016\021\035\022\036\ \020\034\024\035\022 \036\021\027\026\005\016\020\020\032\002 \036)Tj /Span<>> BDC ( )Tj EMC [(\037\020\037\027\022\031 \022\024\024\027\016\b)0.5(\034\036\037\020\022\004 \(N)]TJ /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (43 \022\024\024\027\016\b\034\036\037\020\022\004\))Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf -0.027 Tc 0.027 Tw T* [(T)0.5(a)-35.3(b)-40.7(l)-38.7(e)-27( 4)-38(.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf 0 Tc 0 Tw 3.337 0 Td [( P)19.3(e)-6(r)-32.9(f)-13.3(o)-3(r)-18.6(ma)-5.1(n)-2.9(c)2.8(e m)-5.3(e)-8.5(t)-9.6(r)-39(i)-1.8(c)-26.7(s r)-2(e)-7.7(p)-9.1(o)-3(r)-41.8(t)-1.6(e)-12.9(d b)-2.4(y t)-10.6(h)-2.4(e)]TJ /Span<>> BDC ( )Tj EMC [(s)-14.7(t)-1.1(u)-5.9(d)-3(i)-1.4(e)-22(s i)3.9(n)-2.8(c)-1.1(lu)-5.9(d)-5.3(e)-12.9(d i)3.9(n t)-10.5(h)-2.4(e)]TJ /Span<>> BDC ( )Tj EMC [(a)-5.1(na)-4.5(l)6.6(y)-5.3(s)-12.5(i)6.6(s \()29.7(N)]TJ /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC [(4)13.7(3)68.4(\))]TJ ET /GS2 gs q 1 0 0 1 42.5197 625.8453 cm 0 0 m 170.329 0 l S Q q 1 0 0 1 42.7697 605.0261 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 212.8484 625.8453 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 212.8484 605.0261 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 289.3839 625.8453 cm 0 0 m 70.866 0 l S Q q 1 0 0 1 289.3839 605.0261 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 360.25 625.8453 cm 0 0 m 136.313 0 l S Q q 1 0 0 1 360.25 605.0261 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 496.313 605.0261 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 42.5197 604.7761 cm 0 0 m 170.329 0 l S Q q 1 0 0 1 42.7697 593.5648 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 212.8484 604.7761 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 212.8484 593.5648 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 289.3839 604.7761 cm 0 0 m 70.866 0 l S Q q 1 0 0 1 289.3839 593.5648 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 360.25 604.7761 cm 0 0 m 136.313 0 l S Q q 1 0 0 1 360.25 593.5648 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 593.5648 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 593.3148 cm 0 0 m 170.329 0 l S Q q 1 0 0 1 42.7697 582.1036 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 212.8484 593.3148 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 212.8484 582.1036 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 289.3839 593.3148 cm 0 0 m 70.866 0 l S Q q 1 0 0 1 289.3839 582.1036 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 360.25 593.3148 cm 0 0 m 136.313 0 l S Q q 1 0 0 1 360.25 582.1036 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 582.1036 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 581.8536 cm 0 0 m 170.329 0 l S Q q 1 0 0 1 42.7697 570.6423 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 212.8484 581.8536 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 212.8484 570.6423 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 289.3839 581.8536 cm 0 0 m 70.866 0 l S Q q 1 0 0 1 289.3839 570.6423 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 360.25 581.8536 cm 0 0 m 136.313 0 l S Q q 1 0 0 1 360.25 570.6423 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 570.6423 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 570.3923 cm 0 0 m 170.329 0 l S Q q 1 0 0 1 42.7697 559.181 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 212.8484 570.3923 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 212.8484 559.181 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 289.3839 570.3923 cm 0 0 m 70.866 0 l S Q q 1 0 0 1 289.3839 559.181 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 360.25 570.3923 cm 0 0 m 136.313 0 l S Q q 1 0 0 1 360.25 559.181 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 559.181 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 558.931 cm 0 0 m 170.329 0 l S Q q 1 0 0 1 42.7697 547.7197 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 212.8484 558.931 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 212.8484 547.7197 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 289.3839 558.931 cm 0 0 m 70.866 0 l S Q q 1 0 0 1 289.3839 547.7197 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 360.25 558.931 cm 0 0 m 136.313 0 l S Q q 1 0 0 1 360.25 547.7197 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 547.7197 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 547.4697 cm 0 0 m 170.329 0 l S Q q 1 0 0 1 42.7697 536.2584 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 212.8484 547.4697 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 212.8484 536.2584 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 289.3839 547.4697 cm 0 0 m 70.866 0 l S Q q 1 0 0 1 289.3839 536.2584 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 360.25 547.4697 cm 0 0 m 136.313 0 l S Q q 1 0 0 1 360.25 536.2584 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 536.2584 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 536.0084 cm 0 0 m 170.329 0 l S Q q 1 0 0 1 42.7697 524.7971 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 212.8484 536.0084 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 212.8484 524.7971 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 289.3839 536.0084 cm 0 0 m 70.866 0 l S Q q 1 0 0 1 289.3839 524.7971 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 360.25 536.0084 cm 0 0 m 136.313 0 l S Q q 1 0 0 1 360.25 524.7971 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 524.7971 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 524.5471 cm 0 0 m 170.329 0 l S Q q 1 0 0 1 42.7697 513.3359 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 212.8484 524.5471 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 212.8484 513.3359 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 289.3839 524.5471 cm 0 0 m 70.866 0 l S Q q 1 0 0 1 289.3839 513.3359 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 360.25 524.5471 cm 0 0 m 136.313 0 l S Q q 1 0 0 1 360.25 513.3359 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 513.3359 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 513.0859 cm 0 0 m 170.329 0 l S Q q 1 0 0 1 42.7697 501.8746 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 212.8484 513.0859 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 212.8484 501.8746 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 289.3839 513.0859 cm 0 0 m 70.866 0 l S Q q 1 0 0 1 289.3839 501.8746 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 360.25 513.0859 cm 0 0 m 136.313 0 l S Q q 1 0 0 1 360.25 501.8746 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 501.8746 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 501.6246 cm 0 0 m 170.329 0 l S Q q 1 0 0 1 42.7697 490.4133 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 212.8484 501.6246 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 212.8484 490.4133 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 289.3839 501.6246 cm 0 0 m 70.866 0 l S Q q 1 0 0 1 289.3839 490.4133 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 360.25 501.6246 cm 0 0 m 136.313 0 l S Q q 1 0 0 1 360.25 490.4133 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 490.4133 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 490.1633 cm 0 0 m 170.329 0 l S Q q 1 0 0 1 212.8484 490.1633 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 289.3839 490.1633 cm 0 0 m 70.866 0 l S Q q 1 0 0 1 360.25 490.1633 cm 0 0 m 136.313 0 l S Q BT /GS1 gs /T1_3 1 Tf 8 0 0 8 107.8653 612.4108 Tm (\200\002\220\004\213\004\003\r\f\001)Tj 14.798 0.6 Td (\034\217\217\f\r\240\002\004\b\t\235 )Tj 1.276 -1.2 Td (\(N)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (43\))Tj 8.536 1.2 Td (\022\r\213\210\f\001\003\004\003\013 )Tj 0.025 -1.2 Td (\(\240\t\004\212\004\213\002\b\))Tj 13.371 0.6 Td (\034\217\003\002\201\b\t\220)Tj /T1_1 1 Tf -45.788 -2.033 Td (AUC)Tj 23.101 0 Td (37/43)Tj /Span<>> BDC ( )Tj EMC (\(86%\))Tj 9.587 0 Td (0,58\2260,985)Tj 7.581 0 Td ([1\2265,7\22622,24\22630,32,34\22637,39,41\22643])Tj -40.27 -1.433 Td (\230\024\004\027\024\f\021\034 \(Accuracy\))Tj 22.759 0 Td (20/43)Tj /Span<>> BDC ( )Tj EMC (\(46,5%\))Tj 10.143 0 Td (47,4\22696%)Tj 8.517 0 Td ([1\2267,9,22\22627,29,35,37,39,41,43])Tj -41.419 -1.433 Td (\232\031\r\f\021\r\017\021\036\035\034\027\024\f\021\034)Tj 22.759 0 Td (17/43)Tj /Span<>> BDC ( )Tj EMC (\(39,5%\))Tj 9.893 0 Td (1,75\226100%)Tj 7.518 0 Td ([1\2266,10,16,20,22,23,26,27,32,35,39,41])Tj -40.169 -1.433 Td (\224\023\036\006\017\235\017\004\027\024\f\021\034)Tj 22.759 0 Td (16/43)Tj /Span<>> BDC ( )Tj EMC (\(37,2%\))Tj 10.735 0 Td (0\22698%)Tj 6.675 0 Td ([1\2266,10,16,20,22,23,26,27,32,35,39,41])Tj -40.169 -1.433 Td (\215\024\035\024\032\017\021\036\035\034\027\026\016 \023\030\024\020\027\ \024\f\021\017\004\036\f\022\026\016 \006\036\027\027\024\f\021\034 \(PP\ V\))Tj 23.259 0 Td (4/43)Tj /Span<>> BDC ( )Tj EMC (\(9,3%\))Tj 9.393 0 Td (49,88\22685%)Tj 12.536 0 Td ([16,39,41,43])Tj -45.187 -1.433 Td (\210\021\030\017\006\026\021\036\035\034\027\026\016 \023\030\036\007\017\ \022\021\017\r\027\026\016 \006\036\027\027\024\f\021\034 \(NPV\))Tj 23.601 0 Td (3/43)Tj /Span<>> BDC ( )Tj EMC (\(7%\))Tj 9.393 0 Td (70\226100%)Tj 12.786 0 Td ([39,41,43])Tj -45.78 -1.433 Td (C-inde\b)Tj 23.259 0 Td (4/43)Tj /Span<>> BDC ( )Tj EMC (\(9,3%\))Tj 9.18 0 Td (0,692\2260,929)Tj 12.749 0 Td ([28,31,33,40])Tj -45.187 -1.433 Td (F1-score)Tj 23.601 0 Td (3/43)Tj /Span<>> BDC ( )Tj EMC (\(7%\))Tj 9.3 0 Td (75\22680,8%)Tj 13.128 0 Td ([7,24,43])Tj -46.03 -1.433 Td (Precision)Tj 23.259 0 Td (4/43)Tj /Span<>> BDC ( )Tj EMC (\(9,3%\))Tj 9.393 0 Td (77,16\22690%)Tj 12.786 0 Td ([7,24,29,43])Tj -45.437 -1.433 Td (Recall)Tj 23.601 0 Td (3/43)Tj /Span<>> BDC ( )Tj EMC (\(7%\))Tj 8.921 0 Td (67%\22680,5%)Tj 13.508 0 Td ([7,24,43])Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 9 0 0 9 42.5197 473.444 Tm (\020\004\206\f\t\204\004 5.)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf ( \205\020\037\027\022\031 \013\016\035\016\033\034\013\016\020\020\034\024\ \035\022 \022\024\024\027\016\b\034\036\037\020\022\004)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf -0.027 Tc 0.027 Tw T* [(T)0.5(a)-35.3(b)-40.7(l)-38.7(e)-27( 4)-38(.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf 0 Tc 0 Tw 3.337 0 Td [( Ana)-4.5(l)6.7(y)-5.3(s)0.5(e)-22(s o)4(f)]TJ /Span<>> BDC ( )Tj EMC [(r)-2(e)-22(s)0.5(e)-7.4(a)-4.2(r)-1.6(c)-2.5(h h)-2.4(e)-8.6(t)-1.6(e)-6(r)-2(o)-8.5(g)-6.9(e)-6.9(n)-2.4(e)-6.3(i)-3.4(t)-33.8(y)]TJ ET /GS2 gs q 1 0 0 1 42.5197 458.142 cm 0 0 m 110.801 0 l S Q q 1 0 0 1 42.7697 446.9228 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 153.3209 458.142 cm 0 0 m 104.882 0 l S Q q 1 0 0 1 153.3209 446.9228 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 258.2028 458.142 cm 0 0 m 238.36 0 l S Q q 1 0 0 1 258.2028 446.9228 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 496.313 446.9228 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 42.5197 446.6728 cm 0 0 m 110.801 0 l S Q q 1 0 0 1 42.7697 435.4536 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 153.3209 446.6728 cm 0 0 m 104.882 0 l S Q q 1 0 0 1 153.3209 435.4536 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 258.2028 446.6728 cm 0 0 m 238.36 0 l S Q q 1 0 0 1 258.2028 435.4536 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 496.313 435.4536 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 42.5197 435.2036 cm 0 0 m 110.801 0 l S Q q 1 0 0 1 42.7697 423.9843 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 153.3209 435.2036 cm 0 0 m 104.882 0 l S Q q 1 0 0 1 153.3209 423.9843 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 258.2028 435.2036 cm 0 0 m 238.36 0 l S Q q 1 0 0 1 258.2028 423.9843 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 496.313 423.9843 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 42.5197 423.7343 cm 0 0 m 110.801 0 l S Q q 1 0 0 1 42.7697 412.5151 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 153.3209 423.7343 cm 0 0 m 104.882 0 l S Q q 1 0 0 1 153.3209 412.5151 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 258.2028 423.7343 cm 0 0 m 238.36 0 l S Q q 1 0 0 1 258.2028 412.5151 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 496.313 412.5151 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 42.5197 412.2651 cm 0 0 m 110.801 0 l S Q q 1 0 0 1 153.3209 412.2651 cm 0 0 m 104.882 0 l S Q q 1 0 0 1 258.2028 412.2651 cm 0 0 m 238.36 0 l S Q BT /GS1 gs /T1_3 1 Tf 8 0 0 8 83.2975 449.5074 Tm (\215\r\003\006\t\220\004)Tj 13.259 0 Td (\033\b\004\201\r\b\t\r)Tj 20.146 0 Td (\034\b\003\r\006\212\006\r\003\004\204\t\235)Tj -38.117 -1.434 Td (I\262)Tj /T1_1 1 Tf ( )Tj 4.664 0 0 4.664 53.2362 440.7022 Tm (1)Tj 8 0 0 8 199.0218 438.0461 Tm (97,6)Tj 17.265 0 Td (\200\t\f\024\022\026\016 \020\036\021\036\030\024\020\036\027\027\024\f\021\ \034)Tj /T1_3 1 Tf -36.442 -1.435 Td (p-value Q)Tj /T1_1 1 Tf ( )Tj 4.664 0 0 4.664 79.5077 429.233 Tm (2)Tj 8 0 0 8 194.0899 426.5769 Tm (<)Tj /Span<>> BDC ( )Tj EMC (0,001)Tj 13.842 0 Td (\003\027\026\004\017\n\t\036 \030\026\035\017\004\017\016 \n\036\032\007\ \031 \017\f\f\035\036\007\024\r\026\027\017\016\n\017)Tj ET q 0 0 566.929 793.701 re W n 0.4 w 4 M q 1 0 0 1 46.9083 418.6758 cm 0 0 m -0.272 0 -0.48 -0.064 -0.632 -0.184 c -0.784 -0.312 -0.952 -0.624 -1.136 -1.12 c -0.992 -1.12 l -0.76 -0.696 -0.56 -0.576 -0.136 -0.576 c 0.224 -0.576 l 0.136 -1.432 0.088 -2.04 0.088 -2.416 c 0.088 -2.888 0.16 -3.696 0.808 -3.696 c 1.2 -3.696 1.512 -3.424 1.608 -2.568 c 1.472 -2.568 l 1.4 -2.92 1.24 -3.056 1.024 -3.056 c 0.736 -3.056 0.52 -2.84 0.52 -2.336 c 0.52 -2.016 0.568 -1.432 0.656 -0.576 c 1.872 -0.576 l 1.872 0 l h S Q Q BT /T1_1 1 Tf 8 0 0 8 45.6043 415.0998 Tm (\266)Tj /T1_3 1 Tf (\262)Tj /T1_1 1 Tf ( )Tj 4.664 0 0 4.664 53.9402 417.7638 Tm (3)Tj 8 0 0 8 197.0218 415.1077 Tm (0,289)Tj 12.483 0 Td (\200\t\f\024\022\026\016 \n\036\032\017\f\f\035\036\007\024\r\026\021\036\ \035\034\f\022\026\016 \r\026\030\017\026\002\036\035\034\027\024\f\021\034\ )Tj /T1_2 1 Tf 7 0 0 7 42.5197 400.7805 Tm (\t\033\022\006\016\005\037\020\022\016: )Tj 4.081 0 0 4.081 80.8019 403.1115 Tm (1)Tj 7 0 0 7 82.8424 400.7805 Tm (I\262)Tj /Span<>> BDC ( )Tj EMC [(\227 \f\033\034\007\016\020\035 \b\022\024\f\016\033\024\022\022, \034\025\ \206\030\024\020\030\016\006\034\004 \006\016\201\022\024\024\027\016\b\034\ \036\037)49.4(\035\016\027\003\024\021\034\004 \013\016\035\016\033\034\013\016\020\020\ \034\024\035\003\026,)]TJ 4.081 0 0 4.081 319.0599 403.1115 Tm ( 2)Tj 7 0 0 7 322.0512 400.7805 Tm [(p-v)16(alue Q)]TJ /Span<>> BDC ( )Tj EMC (\227 \035\016\024\035 \r\034\021\033\037\020\037, )Tj 4.081 0 0 4.081 402.3466 403.1115 Tm (3)Tj 7 0 0 7 404.3871 400.7805 Tm (\251\262)Tj /Span<>> BDC ( )Tj EMC (\227 \034\007\016\020\021\037 )Tj -51.695 -1.2 Td [(\006\016\201\022\024\024\027\016\b\034\036\037)49.1(\035\016\027\003\024\021\034\004 \b\022\024\f\016\033\024\022\022.)]TJ ET q 42.52 122.57 221.102 117.137 re W n q /GS0 gs 221.1023475 0 0 117.1530471 42.5196833 122.5539276 cm /Im0 Do Q Q BT 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0.169 Tw 9 0 0 9 42.5197 111.7701 Tm (\022\t\217\210\b\002\220 2.)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf ( \223\033\037\017\022\021 Forest plot \034\025\206\016\b\022\020\246\020\ \020\032\002 \034\007\016\020\034\021 AUC )Tj 0 Tw T* (\f\034)Tj /Span<>> BDC ( )Tj EMC (\036\021\027\026\005\246\020\020\032\006 \022\024\024\027\016\b\034\036\037\ \020\022\030\006)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0.048 Tw T* [(F)-16(igure 2)16(.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf [( Graph F)12(orest plo)13(t of)]TJ /Span<>> BDC ( )Tj EMC [(combined estimates A)29(UC for in)]TJ 0 Tw (-)Tj T* (cluded studies)Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\007\003\032)50(\n\n\217\n)-21(\035\030\002)]TJ 53.418 0 Td [(MET)30(A)-41(-)-41.9(ANAL)30(Y)30(SIS)]TJ /T1_4 1 Tf 25 0 0 25 505.4645 56.0378 Tm (133)Tj ET endstream endobj 1501 0 obj <>stream Adobed     '$''''$25552;;;;;;;;;;   ####''',,,   ####''',,,   ####''',,,""  ^C !"#$%&'()*123456789:ABCDEFGHIJQRSTUVWXYZabcdefghijqrstuvwxyz!1AQ"2a#BqrRSb $%&'()*3456789:CDEFGHIJTUVWXYZcdefghijstuvwxyz?"S K95ˈtUQA Q Ɨ6 3k%pq$uE^M5Z+4cv0^ 4 @, 0, @ 04R   'h60o h'`1tb@$EI]eV;vm] 6s$Hc""uDD@DD@DD@DD@DYwA:!r"n Rs 5xSPj5"iS.o*Wa*cKCAu#a@S q]R^)RcRXƂ\8I8.\Z:hY?@z'm9se&\Ap-DJ"Ƣ7}.Xig,idC2C˃@+S^<ץ`m&8UaK\C`Ȃ$ )_/DuRo Aw&.xcIZ2qW@Eu$7RN-0DDЪ" ).Rnժ `}RAttkE:8 )E_QhIʯ>?{?ޫ}*WCC"*tʝfg'^byCZOޤfhP:b>]ܖ-2k|{>?{?Ӷ>?} ƛSкՙgZ!1:zAU.4 0>h@XYN@XYN@XYN4,z,l}Gqt~l}Gqt~?=C>?{?Ӷ>?{?=C>?{?Ӷ>?{?=C>?} Q]!Q]Q]!Q]Q]!Q]Q]!Q]Q]EE폨.폨.CG"ǢvwGGvwGG"ǢvwGGvwGG"ǢvwGGvwGGAH14& $`4 Ah!e1t]N@`R)@j-뎂sXX 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[MiWuJn{Z<v<rd4v#5aU 5L5ҸNv,zBDhs5+sX Ɍ )htij* ᄹh6Ky  5tIqN/F'8}.3vԿCձMGhSjD$1`;y8 *z:/,_=Ԛ4'y2mfpH5cja-]1y}Fp@w\:Me6WfƱ2 ]i|]V9 6bԊia90Hi[Ps4k-ťimc:!юm"7]YKjTTsP84 92OFtZ0Ӛ q[A.x.Ӷqv[[鶫fe71ԃEs aGfU:)Fh0ju. z2l@^;5t̢)eE˜0OS`p^tLA$+tZE^kJ%9T>uB 4hABUz >ZkCL>Ɋ..q֝nT_sGH5:fitED@Ҫ" < Em+]=WѨ8i!V:5wnXO~Ā WX`CX\v诜_Š(`H<-!Wk}٫E  7=wK֘ᨬ~ĝ:0Dv3V9=p9x$ }{٫_9 _@PN8<v }=i=膰{IE E{٫o9 g@PAx+mWCWfӶE|5~j-CA_9 _N}٫E  E|5~j-;mWCWf0x$ }٫_9 _@Px+mWCWfӶE|5~j-CA_9 _N}٫E  E|5~j-;mWCWf0x$ }٫_9 _@Px+mWCWfӶE|5~j-CA_9 _N}{٫E  E|5j-;mWCWf Aa; F)P^ +@<`X V{<-m@e'h 74 1tb@$"H ߙvAj-GZmEGUը.Q's$k Ѯ~FVRvOm dqM_Š(3A= `Wio=5ǭ5z6fuxQs81oJ\قD_mDGZ\L9[oUj:%ճj V6Fq'jӪ" +Me= B淒h/5hm@ZmX@_2Wck*}3HȮChnV 1 ,-PP={E:R,yuA}wjLjy01g㈀Z.Jffnhw:_8d6i+z c9IuO) N8ؾ2 4-M--ZuMFŵumWG%͎ݹz+zT{4/aO,k3#"s(ZN|YtH0mp3+}fMK|DW=cn$y*3XOC^ТWq7d ǩ_xI=Op*@^ǩ_xI=Op*@^ǩ_xI=Op*@^ǩ_xKHQa`.?н]*ZMMvע\ZjȪ + ^MкZᬾڹ*\m!ͮ*9dҒizu}eJNT< msIW|s^HiZn@_.膰eZ!Ty ϴrd;{>Z}U] Q sn5%Q= ːHi-=縹kI''+"l8PVUZ۞,2˶PhYEwSЃUuCGYWKVZl1Đ$;toQTYZњcuɺ*3H({hk|WN7UȰ@"Z~oZkϪRv+DEOm oJtGTz'4UKQmmtDl.zNMW tO8κCcȆ t4Z;))MTEhc#(;hk|WN7UȀu_W);hk|WS""y_GD}CQ.uZH;cڽ =>GenT[Zvse\EL#2@DDDDDDDDDDDDDDDDDժ"mI.r`MmI K=I"@VVz›X9;)"wX@2dF'D&9!k*ˁ,|8u"4@WQ讧NNsz鄱Ɛ簑-{m ;hB $d\,Akujv!N9C^Sc8q bcTi*4ZI49ʍ4ׂ"Y[:fSFkhkRfsZDҨpђ g+W*z澏EDk5*8WTڼ/Ұ@X#=S H im6Z) @e6 ǪY΃L E.ںC/$I9֓p mq` +zաMKn5-NӾ 7K= ̠/푪chU+sXu, ;ATqt<jO#hsG_^`i%ED_(;MfRPsuCH vknqv>j:"F&8I}=P+QmN9^L^E6C&si3[-F5l mJ-MZR \;`fu}3NTq-<ZGnzx总Uz4ӚijaC*O+mPė0`/JϭA[OM&wGQ swERקJ-MzDAT\h4@tP':VXZ4 Z籯"C[>stream endstream endobj 1499 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.16 Tw 10 0 0 10 70.8661 286.4219 Tm (\017)Tj /Span<>> BDC ( )Tj EMC (\b\026\030\026\022\021\036\030 \023\030\024\r\036\007\201\027\027\024\020\ \024 \035\036\004\036\027\017\016. \215\030\036\007\f\021\026\r\035\036\027\ \027\t\036 )Tj 0.171 Tw 0 -1.218 TD [(\007\026\027\027\t\036 \f\035\031\032\026\021 )0.5(\024\002\024\030\024\n \017\f\f\035\036\007\024\r\026\021\036\035\034\f\ \022\024\020\024 \007\017\026\005)]TJ 0 Tw (-)Tj 0.128 Tw T* (\027\026 \017)Tj /Span<>> BDC ( )Tj EMC (\n\036\021\024\007\024\035\024\020\017\004\036\f\022\017\b \023\024\007\b\ \024\007\024\r, \023\024\r\024\035\016\016 \024\006\036\027\017\021\034\ )Tj 0.121 Tw T* (\n\026\f\001\021\026\002\t \r\t\002\024\030\024\022 \017)Tj /Span<>> BDC ( )Tj EMC (\024\002\024\f\027\024\r\026\027\027\024\f\021\034 \017\f\023\024\035\034\ \031\036\n\t\b )Tj 0.17 Tw T* (\n\024\007\036\035\036\005. \200)Tj /Span<>> BDC ( )Tj EMC (\021\026\002\035\017\006\036 3 \023\030\036\007\f\021\026\r\035\036\027\024\ \030\026\f\023\030\036\007\036\035\036\027\017\036 )Tj 0 Tw T* (\017\f\f\035\036\007\024\r\026\027\017\005 \023\024)Tj /Span<>> BDC ( )Tj EMC (\022\024\035\017\004\036\f\021\r\031 \017\031\004\036\027\027\t\b \023\030\ \017\027\026\022\024\r.)Tj T* [(\236 )0.5(\023\030\036\007\f\021\026\r\035\036\027\027\t\b )0.6(\007\026\027\027\t\b )0.5(\f\035\036\007\031\036\021, )0.5(\004\021\024 )0.5(\002\024\035\034\001\017\027\f\021\r\024 )]TJ 0.293 Tw T* (\017\f\f\035\036\007\024\r\026\027\017\005 \(16 \017\f\f\035\036\007\024\ \r\026\027\017\005, 37,2%\) \r\022\035\033\004\026\035\017 )Tj 0.104 Tw T* (10\22615)Tj /Span<>> BDC ( )Tj EMC (\023\030\017\027\026\022\024\r \007\035\016 \023\030\024\r\036\007\036\027\ \017\016 \007\026\035\034\027\036\005\001\036\020\024 \026\027\026)Tj 0 Tw (-)Tj -0.024 Tw T* (\035\017\026. \215\024\022\026\026\021\036\035\017 \220\235\235\036\022\ \021\017\r\027\024\f\021\017 \r\024 \r\022\035\033\004\036\027\027\t\b \f\ \021\026)Tj 0 Tw (-)Tj T* (\021\034\016\b \023\030\036\007\f\021\026\r\035\036\027\t \r)Tj /Span<>> BDC ( )Tj EMC (\021\026\002\035\017\006\036 4.)Tj 0.117 Tw T* (\025\026\022 \023\030\036\007\f\021\026\r\035\036\027\024 \r)Tj /Span<>> BDC ( )Tj EMC (\021\026\002\035\017\006\036 4, \027\026\017\002\024\035\036\036 \004\026\ \f\021\024 \023\030\017)Tj 0 Tw (-)Tj 0.458 Tw T* [(\n\036\027\016\r\001\017\n\f\016 )0.5(\023\024\022\026\026\021\036\035\036\n )0.6(\220\235\235\036\022\021\017\r\027\024\f\021\017 )0.6(\016\r\017\035\026\f\034 )]TJ 0.444 Tw T* (\023\035\024\013\026\007\034 \023\024\007 )Tj /T1_1 1 Tf -0.019 Tc 0.019 Tw [(RO)-18.9(C)]TJ /T1_0 1 Tf 0 Tc 0.444 Tw 7.871 0 Td [(-\022\030\017\r\024\005 \(A)17(UC\), \235\017\020\031\030\017\030\024\r\026\r\001\026\016 )]TJ 0.168 Tw -7.871 -1.218 Td (\r)Tj /Span<>> BDC ( )Tj EMC (37/43 \(86%\) \017\f\f\035\036\007\024\r\026\027\017\016\b \f)Tj /Span<>> BDC ( )Tj EMC (\007\017\026\023\026\024\027\024\n \027\026\004\036)Tj 0 Tw (-)Tj 0.125 Tw T* (\027\017\005 \024\021 0,58 \007\024)Tj /Span<>> BDC ( )Tj EMC [(0,985. \230\024\004\027\024\f\021\034 \(A)-25(ccur)-33(a)-17(cy\) \023\030\017\n\036\027\016)]TJ 0 Tw (-)Tj 0.169 Tw T* [(\035\026\f\034 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC [(20/43 \(46,5%\) )0.5(\030\026\002\024\021\026\b \027\026\004\036\027\017\016 )0.6(\r\026\030\034\017\030\024\r\026)]TJ 0 Tw (-)Tj 0.081 Tw T* (\035\017\f\034 \024\021 47,4% \007\024)Tj /Span<>> BDC ( )Tj EMC (96%. \215\024\022\026\026\021\036\035\034 \004\031\r\f\021\r\017\021\036\ \035\034\027\024\f\021\017 )Tj 0.034 Tw 23.244 20.703 Td [(\(Sensi)-24(t)-32(i)-15.9(v)-16(i)-24(t)-10(y\) \023\030\017\n\036\027\016\035\f\016 \r)]TJ /Span<>> BDC ( )Tj EMC (17/43 \(39,5%\) \017\f\f\035\036\007\024\r\026)Tj 0 Tw (-)Tj -0.046 Tw T* [(\027\017\016\b, \f\023\036\006\017\235\017\004\027\024\f\021\017 \(Spec)-24(i\251c)-23.9(i)-24(t)-10(y\) \r)]TJ /Span<>> BDC ( )Tj EMC (16/43 \(37,2%\) \017\f)Tj 0 Tw (-)Tj 0.028 Tw T* (\f\035\036\007\024\r\026\027\017\016\b, \027\026\004\036\027\017\016 \004\ \031\r\f\021\r\017\021\036\035\034\027\024\f\021\017 \022\024\035\036\002\ \026\035\017\f\034 )Tj 0.122 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\023\030\036\007\036\035\026\b 1,75\226100%, \026)Tj /Span<>> BDC ( )Tj EMC (\f\023\036\006\017\235\017\004\027\024\f\021\017)Tj /Span<>> BDC ( )Tj EMC (\227 0\22698%. )Tj -0.04 Tw T* (\215\024\035\024\032\017\021\036\035\034\027\026\016 \023\030\024\020\027\ \024\f\021\017\004\036\f\022\026\016 \006\036\027\027\024\f\021\034 \(PP\ V\) \023\030\017)Tj 0 Tw (-)Tj 0.05 Tw T* (\n\036\027\016\035\026\f\034 \r)Tj /Span<>> BDC ( )Tj EMC (4/43 \(9,3%\) \017\f\f\035\036\007\024\r\026\027\017\016\b \017)Tj /Span<>> BDC ( )Tj EMC (\027\026\b\024\007\017\035\026\f\034 )Tj -0.053 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\007\017\026\023\026\024\027\036 49,88\22685%, \021\024\020\007\026 \022\ \026\022 \024\021\030\017\006\026\021\036\035\034\027\026\016 \023\030\024\ )Tj 0 Tw (-)Tj 0.134 Tw T* (\020\027\024\f\021\017\004\036\f\022\026\016 \006\036\027\027\024\f\021\034\ \(NPV\))Tj /Span<>> BDC ( )Tj EMC (\227 \r)Tj /Span<>> BDC ( )Tj EMC (3/43 \(7%\) \f)Tj /Span<>> BDC ( )Tj EMC (\030\026)Tj 0 Tw (-)Tj 0.33 Tw T* [(\002\030\024\f\024\n \027\026\004\036\027\017\005 )0.5(70\226100%. \215\024\022\026\026\021\036\035\034 C-\017\027\007\036\022\ \f\026 )]TJ 0.117 Tw T* (\235\017\020\031\030\017\030\024\r\026\035 \r)Tj /Span<>> BDC ( )Tj EMC (4/43 \(9,3%\) \017\f\f\035\036\007\024\r\026\027\017\016\b \017)Tj /Span<>> BDC ( )Tj EMC (\r\026\030\034\017)Tj 0 Tw (-)Tj 0.004 Tw T* (\030\024\r\026\035 \024\021 0,692 \007\024)Tj /Span<>> BDC ( )Tj EMC [(0,929. F1-scor)-23.9(e \235\017\020\031\030\017\030\024\r\026\035 \r)]TJ /Span<>> BDC ( )Tj EMC (2/43 )Tj 0.165 Tw T* (\(7%\) \017\f\f\035\036\007\024\r\026\027\017\005 \f)Tj /Span<>> BDC ( )Tj EMC (\007\017\026\023\026\024\027\024\n \027\026\004\036\027\017\005 \024\021\ 75% )Tj -0.016 Tw T* (\007\024)Tj /Span<>> BDC ( )Tj EMC [(80,8%, P)35(r)-24(ec)-24(ision 4/43 \(9,3%\))]TJ /Span<>> BDC ( )Tj EMC (\227 77,16\22690% \017)Tj /Span<>> BDC ( )Tj EMC [(R)13(ecall )]TJ 0 Tw T* (3/43 \(7%\))Tj /Span<>> BDC ( )Tj EMC (\227 67\22680,5%.)Tj /T1_2 1 Tf 0 -2.436 TD (\n\005\b\020\020\002\020\001\007)Tj /T1_0 1 Tf 0.065 Tw 0 -1.218 TD [(\217\036\031\035\034\021\026\021\t \024\006\036\027\022\017 \023\035\024\ \013\026\007\017 \023\024\007 \022\030\017\r\024\005 \(A)17(UC\) \023\030\036\007)]TJ 0 Tw (-)Tj 0.359 Tw T* [(\f\021\026\r\035\036\027\t )0.5(\027\026)]TJ /Span<>> BDC ( )Tj EMC [(\024\f\027\024\r\036 )0.5(12 \017\f\f\035\036\007\024\r\026\027\017\005, )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC (\022\024\021\024\030\t\b )Tj ET 0 0 0 1 K 0.5 w /GS2 gs q 1 0 0 1 70.8661 736.7579 cm 0 0 m 42.77 0 l S Q q 1 0 0 1 71.1161 710.2637 cm 0 0 m 0 26.244 l S Q q 1 0 0 1 113.6358 736.7579 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 113.6358 710.2637 cm 0 0 m 0 26.244 l S Q q 1 0 0 1 158.9902 736.7579 cm 0 0 m 68.031 0 l S Q q 1 0 0 1 158.9902 710.2637 cm 0 0 m 0 26.244 l S Q q 1 0 0 1 227.0217 736.7579 cm 0 0 m 158.74 0 l S Q q 1 0 0 1 227.0217 710.2637 cm 0 0 m 0 26.244 l S Q q 1 0 0 1 385.7618 736.7579 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 385.7618 710.2637 cm 0 0 m 0 26.244 l S Q q 1 0 0 1 445.2894 736.7579 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 445.2894 710.2637 cm 0 0 m 0 26.244 l S Q q 1 0 0 1 487.8091 736.7579 cm 0 0 m 37.1 0 l S Q q 1 0 0 1 487.8091 710.2637 cm 0 0 m 0 26.244 l S Q q 1 0 0 1 524.6594 710.2637 cm 0 0 m 0 26.244 l S Q q 1 0 0 1 70.8661 710.0137 cm 0 0 m 42.77 0 l S Q q 1 0 0 1 71.1161 635.5264 cm 0 0 m 0 74.237 l S Q q 1 0 0 1 113.6358 710.0137 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 113.6358 635.5264 cm 0 0 m 0 74.237 l S Q q 1 0 0 1 158.9902 710.0137 cm 0 0 m 68.031 0 l S Q q 1 0 0 1 158.9902 635.5264 cm 0 0 m 0 74.237 l S Q q 1 0 0 1 227.0217 710.0137 cm 0 0 m 158.74 0 l S Q q 1 0 0 1 227.0217 635.5264 cm 0 0 m 0 74.237 l S Q q 1 0 0 1 385.7618 710.0137 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 385.7618 635.5264 cm 0 0 m 0 74.237 l S Q q 1 0 0 1 445.2894 710.0137 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 445.2894 635.5264 cm 0 0 m 0 74.237 l S Q q 1 0 0 1 487.8091 710.0137 cm 0 0 m 37.1 0 l S Q q 1 0 0 1 487.8091 635.5264 cm 0 0 m 0 74.237 l S Q q 1 0 0 1 524.6594 635.5264 cm 0 0 m 0 74.237 l S Q q 1 0 0 1 70.8661 635.2764 cm 0 0 m 42.77 0 l S Q q 1 0 0 1 71.1161 608.7891 cm 0 0 m 0 26.237 l S Q q 1 0 0 1 113.6358 635.2764 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 113.6358 608.7891 cm 0 0 m 0 26.237 l S Q q 1 0 0 1 158.9902 635.2764 cm 0 0 m 68.031 0 l S Q q 1 0 0 1 158.9902 608.7891 cm 0 0 m 0 26.237 l S Q q 1 0 0 1 227.0217 635.2764 cm 0 0 m 158.74 0 l S Q q 1 0 0 1 227.0217 608.7891 cm 0 0 m 0 26.237 l S Q q 1 0 0 1 385.7618 635.2764 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 385.7618 608.7891 cm 0 0 m 0 26.237 l S Q q 1 0 0 1 445.2894 635.2764 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 445.2894 608.7891 cm 0 0 m 0 26.237 l S Q q 1 0 0 1 487.8091 635.2764 cm 0 0 m 37.1 0 l S Q q 1 0 0 1 487.8091 608.7891 cm 0 0 m 0 26.237 l S Q q 1 0 0 1 524.6594 608.7891 cm 0 0 m 0 26.237 l S Q q 1 0 0 1 70.8661 608.5391 cm 0 0 m 42.77 0 l S Q q 1 0 0 1 71.1161 582.0518 cm 0 0 m 0 26.237 l S Q q 1 0 0 1 113.6358 608.5391 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 113.6358 582.0518 cm 0 0 m 0 26.237 l S Q q 1 0 0 1 158.9902 608.5391 cm 0 0 m 68.031 0 l S Q q 1 0 0 1 158.9902 582.0518 cm 0 0 m 0 26.237 l S Q q 1 0 0 1 227.0217 608.5391 cm 0 0 m 158.74 0 l S Q q 1 0 0 1 227.0217 582.0518 cm 0 0 m 0 26.237 l S Q q 1 0 0 1 385.7618 608.5391 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 385.7618 582.0518 cm 0 0 m 0 26.237 l S Q q 1 0 0 1 445.2894 608.5391 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 445.2894 582.0518 cm 0 0 m 0 26.237 l S Q q 1 0 0 1 487.8091 608.5391 cm 0 0 m 37.1 0 l S Q q 1 0 0 1 487.8091 582.0518 cm 0 0 m 0 26.237 l S Q q 1 0 0 1 524.6594 582.0518 cm 0 0 m 0 26.237 l S Q q 1 0 0 1 70.8661 581.8018 cm 0 0 m 42.77 0 l S Q q 1 0 0 1 71.1161 555.3145 cm 0 0 m 0 26.237 l S Q q 1 0 0 1 113.6358 581.8018 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 113.6358 555.3145 cm 0 0 m 0 26.237 l S Q q 1 0 0 1 158.9902 581.8018 cm 0 0 m 68.031 0 l S Q q 1 0 0 1 158.9902 555.3145 cm 0 0 m 0 26.237 l S Q q 1 0 0 1 227.0217 581.8018 cm 0 0 m 158.74 0 l S Q q 1 0 0 1 227.0217 555.3145 cm 0 0 m 0 26.237 l S Q q 1 0 0 1 385.7618 581.8018 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 385.7618 555.3145 cm 0 0 m 0 26.237 l S Q q 1 0 0 1 445.2894 581.8018 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 445.2894 555.3145 cm 0 0 m 0 26.237 l S Q q 1 0 0 1 487.8091 581.8018 cm 0 0 m 37.1 0 l S Q q 1 0 0 1 487.8091 555.3145 cm 0 0 m 0 26.237 l S Q q 1 0 0 1 524.6594 555.3145 cm 0 0 m 0 26.237 l S Q q 1 0 0 1 70.8661 555.0645 cm 0 0 m 42.77 0 l S Q q 1 0 0 1 71.1161 536.5772 cm 0 0 m 0 18.237 l S Q q 1 0 0 1 113.6358 555.0645 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 113.6358 536.5772 cm 0 0 m 0 18.237 l S Q q 1 0 0 1 158.9902 555.0645 cm 0 0 m 68.031 0 l S Q q 1 0 0 1 158.9902 536.5772 cm 0 0 m 0 18.237 l S Q q 1 0 0 1 227.0217 555.0645 cm 0 0 m 158.74 0 l S Q q 1 0 0 1 227.0217 536.5772 cm 0 0 m 0 18.237 l S Q q 1 0 0 1 385.7618 555.0645 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 385.7618 536.5772 cm 0 0 m 0 18.237 l S Q q 1 0 0 1 445.2894 555.0645 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 445.2894 536.5772 cm 0 0 m 0 18.237 l S Q q 1 0 0 1 487.8091 555.0645 cm 0 0 m 37.1 0 l S Q q 1 0 0 1 487.8091 536.5772 cm 0 0 m 0 18.237 l S Q q 1 0 0 1 524.6594 536.5772 cm 0 0 m 0 18.237 l S Q q 1 0 0 1 70.8661 536.3272 cm 0 0 m 42.77 0 l S Q q 1 0 0 1 71.1161 517.84 cm 0 0 m 0 18.237 l S Q q 1 0 0 1 113.6358 536.3272 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 113.6358 517.84 cm 0 0 m 0 18.237 l S Q q 1 0 0 1 158.9902 536.3272 cm 0 0 m 68.031 0 l S Q q 1 0 0 1 158.9902 517.84 cm 0 0 m 0 18.237 l S Q q 1 0 0 1 227.0217 536.3272 cm 0 0 m 158.74 0 l S Q q 1 0 0 1 227.0217 517.84 cm 0 0 m 0 18.237 l S Q q 1 0 0 1 385.7618 536.3272 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 385.7618 517.84 cm 0 0 m 0 18.237 l S Q q 1 0 0 1 445.2894 536.3272 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 445.2894 517.84 cm 0 0 m 0 18.237 l S Q q 1 0 0 1 487.8091 536.3272 cm 0 0 m 37.1 0 l S Q q 1 0 0 1 487.8091 517.84 cm 0 0 m 0 18.237 l S Q q 1 0 0 1 524.6594 517.84 cm 0 0 m 0 18.237 l S Q q 1 0 0 1 70.8661 517.59 cm 0 0 m 42.77 0 l S Q q 1 0 0 1 71.1161 483.1027 cm 0 0 m 0 34.237 l S Q q 1 0 0 1 113.6358 517.59 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 113.6358 483.1027 cm 0 0 m 0 34.237 l S Q q 1 0 0 1 158.9902 517.59 cm 0 0 m 68.031 0 l S Q q 1 0 0 1 158.9902 483.1027 cm 0 0 m 0 34.237 l S Q q 1 0 0 1 227.0217 517.59 cm 0 0 m 158.74 0 l S Q q 1 0 0 1 227.0217 483.1027 cm 0 0 m 0 34.237 l S Q q 1 0 0 1 385.7618 517.59 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 385.7618 483.1027 cm 0 0 m 0 34.237 l S Q q 1 0 0 1 445.2894 517.59 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 445.2894 483.1027 cm 0 0 m 0 34.237 l S Q q 1 0 0 1 487.8091 517.59 cm 0 0 m 37.1 0 l S Q q 1 0 0 1 487.8091 483.1027 cm 0 0 m 0 34.237 l S Q q 1 0 0 1 524.6594 483.1027 cm 0 0 m 0 34.237 l S Q q 1 0 0 1 70.8661 482.8527 cm 0 0 m 42.77 0 l S Q q 1 0 0 1 71.1161 424.3584 cm 0 0 m 0 58.244 l S Q q 1 0 0 1 113.6358 482.8527 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 113.6358 424.3584 cm 0 0 m 0 58.244 l S Q q 1 0 0 1 158.9902 482.8527 cm 0 0 m 68.031 0 l S Q q 1 0 0 1 158.9902 424.3584 cm 0 0 m 0 58.244 l S Q q 1 0 0 1 227.0217 482.8527 cm 0 0 m 158.74 0 l S Q q 1 0 0 1 227.0217 424.3584 cm 0 0 m 0 58.244 l S Q q 1 0 0 1 385.7618 482.8527 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 385.7618 424.3584 cm 0 0 m 0 58.244 l S Q q 1 0 0 1 445.2894 482.8527 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 445.2894 424.3584 cm 0 0 m 0 58.244 l S Q q 1 0 0 1 487.8091 482.8527 cm 0 0 m 37.1 0 l S Q q 1 0 0 1 487.8091 424.3584 cm 0 0 m 0 58.244 l S Q q 1 0 0 1 524.6594 424.3584 cm 0 0 m 0 58.244 l S Q q 1 0 0 1 70.8661 424.1084 cm 0 0 m 42.77 0 l S Q q 1 0 0 1 113.6358 424.1084 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 158.9902 424.1084 cm 0 0 m 68.031 0 l S Q q 1 0 0 1 227.0217 424.1084 cm 0 0 m 158.74 0 l S Q q 1 0 0 1 385.7618 424.1084 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 445.2894 424.1084 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 487.8091 424.1084 cm 0 0 m 37.1 0 l S Q BT /GS1 gs /T1_3 1 Tf 0 Tw 5.6 0 0 7 79.6334 720.8483 Tm (\032\003\002\006, \n\002\240)Tj 8.046 0 Td (\032\f\n\002\006\t\003\214)Tj 6.778 0.571 Td (\200\006\002\n\b\002\213\t\006\210\r\214\013\005 \220\f\t\b\t)Tj 5.6 0 0 7 221.294 724.8483 Tm (-)Tj 5.6 0 0 7 176.7941 716.8483 Tm (\201\r\217\220\t\005 \t\217\216\002\240)Tj 20.633 0.571 Td (\022\r\213\210\f\001\003\004\003\013)Tj 18.177 0 Td (\215\r\003\002\240 \004\f\t\240\004\204\t\t)Tj 10.554 1.143 Td (\030\t\217\f\002 \004\b\004)Tj 5.6 0 0 7 477.791 728.8483 Tm (-)Tj 5.6 0 0 7 451.4406 720.8483 Tm (\f\t\213\t\006\210\r\214\013\216 )Tj 0.134 -1.143 Td (\212\004\006\004\214\r\003\006\002)Tj 7.129 1.714 Td (\021\002\f\t\201\r\217\003\002 )Tj 0.229 -1.143 Td (\212\004\204\t\r\b\003\002)Tj /T1_0 1 Tf -74.901 -2.105 Td (Li J. et al., 2023 )Tj 0 -1.143 TD ([43])Tj 8.898 1.143 Td (ML models:)Tj -1.129 -1.143 Td (SVM, KNN, DT, RF, )Tj 1.087 -1.143 Td (extra trees.)Tj -0.175 -1.143 Td (NLP models:)Tj -0.12 -1.143 Td (bidirectional )Tj 0.972 -1.143 Td (encoder )Tj -1.545 -1.143 Td (representations )Tj -0.23 -1.143 Td (from transformer )Tj 1.999 -1.143 Td (\(BERT\))Tj 7.684 9.143 Td (\204\036\021\026\f\021\026\017\030\024\r\026\027\017\036 )Tj 2.037 -1.143 Td (\r)Tj /Span<>> BDC ( )Tj EMC (\023\036\004\036\027\034)Tj 9.42 1.143 Td (Accuracy 80,8%; precision 80,3%; recall 80,5%; F1-score 80,8%)Tj 27.904 0 Td (\200\027\036\001\027\016\016-\r\026\035\017\007\026\006\017\016)Tj 12.805 0 Td (20)Tj 6.587 0 Td (1463)Tj -76.193 -10.677 Td (Liu Y. et al., )Tj 0 -1.143 TD (2023 [35])Tj 7.682 1.143 Td (XGBoost, RF, SVM, )Tj 2.606 -1.143 Td (KNN)Tj 9.226 1.143 Td (\217\036\006\017\007\017\r)Tj 20.192 0 Td (XGBoost:)Tj -9.207 -1.143 Td (AUC 0,952 KNN: \202ccuracy)Tj /Span<>> BDC ( )Tj EMC (\227 0,935, Speci\251city)Tj /Span<>> BDC ( )Tj EMC (\227 0,932)Tj 6.307 -1.143 Td (RF: Sensitivity)Tj /Span<>> BDC ( )Tj EMC (\227 0,959)Tj 20.426 2.286 Td (10-\022\030\026\021\027\026\016 \022\030\024\f\f-)Tj 1.57 -1.143 Td (\r\026\035\017\007\026\006\017\016)Tj 10.804 1.143 Td (44)Tj 6.587 0 Td (1187)Tj -76.193 -3.82 Td (Ishizaki, Tetsuo )Tj 0 -1.143 TD (et al., 2023 )Tj T* ([36])Tj 8.686 2.286 Td (NN, XGBoost)Tj 11.768 0 Td (\207\217\200)Tj 19.037 0 Td (AUC 0,775)Tj 17.875 0 Td (5- \022\030\026\021\027\026\016 \022\030\024\f\f-)Tj 1.436 -1.143 Td (\r\026\035\017\007\026\006\017\016)Tj 10.804 1.143 Td (14)Tj 6.837 0 Td (259)Tj -76.443 -3.82 Td (Bibault, Jean-)Tj T* (Emmanuel et )Tj 0 -1.143 TD (al., 2021 [37])Tj 9.484 2.286 Td (XGBoost)Tj 8.928 0 Td (10- \035\036\021\027\016\016 \210\200)Tj 18.404 0 Td (AUC 0,84, accuracy 0,83)Tj 21.044 0 Td (\025\030\026\021\027\026\016 \022\030\024\f\f-)Tj 0.943 -1.143 Td (\r\026\035\017\007\026\006\017\016)Tj 10.804 1.143 Td (29)Tj 6.587 0 Td (2359)Tj -76.193 -3.82 Td (Amygdalos, I. et )Tj 0 -1.143 TD (al., 2023 [38])Tj 10.086 1.143 Td (GBDT)Tj 10.623 0 Td (\210\200)Tj 12.478 0 Td (AUC 0,72; Accuracy 0,69; Sensitivity 0,73;)Tj 5.263 -1.143 Td (Speci\251city 0,66)Tj 18.96 1.143 Td (\025\030\024\f\f-\r\026\035\017\007\026\006\017\016)Tj 12.198 0 Td (24)Tj 6.837 0 Td (487)Tj -76.443 -2.677 Td (Piao Z. et al., )Tj T* (2023 [39])Tj 9.214 1.143 Td (LightGBM)Tj 8.227 0 Td (\204\036\021\026\f\021\026\017\030\024\r\026\027\017\036 )Tj 1.118 -1.143 Td (\r)Tj /Span<>> BDC ( )Tj EMC (\035\017\n\235\024\031\035\t)Tj 13.735 1.143 Td (AUC 0,960; speci\251city 85,8%; accuracy 92,9%;)Tj 1.18 -1.143 Td (PPV 36,3%; NPV 100%; sensitivity 100%)Tj 23.891 1.143 Td (5- \022\030\026\021\027\026\016 \022\030\024\f\f-)Tj 1.436 -1.143 Td (\r\026\035\017\007\026\006\017\016)Tj 10.804 1.143 Td (12)Tj 6.837 0 Td (651)Tj -76.443 -2.677 Td (Yang, Xulin )Tj T* (et)Tj /Span<>> BDC ( )Tj EMC (al., 2023 )Tj 0 -1.143 TD ([40])Tj 9.483 2.286 Td (RF, GBM, )Tj -0.306 -1.143 Td (DeepSurv, )Tj -0.749 -1.143 Td (DeepHit, Cox-)Tj 0.015 -1.143 Td (Time, N-MTLR)Tj 10.08 3.429 Td (5-\035\036\021\027\016\016 \207\217\200)Tj 18.38 0 Td (DeepHit: \224-index 0,789)Tj 0.523 -1.143 Td (RF: Brier score 0,096)Tj 19.94 1.143 Td (5- \022\030\026\021\027\026\016 \022\030\024\f\f-)Tj 1.436 -1.143 Td (\r\026\035\017\007\026\006\017\016)Tj 10.804 1.143 Td (23)Tj 6.587 0 Td (2157)Tj -76.193 -4.962 Td (Mohammadi)Tj /Span<>> BDC ( )Tj EMC (G. )Tj 0 -1.143 TD (et al., 2024 )Tj T* ([41])Tj 7.96 2.286 Td (LR, NB, SVM, NN, )Tj 1.362 -1.143 Td (DT, LGBM)Tj 6.712 1.143 Td (\206\024\f\023\017\021\026\035\034\027\026\016 \f\n\036\030\021\027\024\f\ \021\034)Tj /T1_3 1 Tf 24.614 -0.001 Td (AUC)Tj /T1_0 1 Tf -4.376 -1.143 Td (NB)Tj /Span<>> BDC ( )Tj EMC (\227 0,70; LGBM)Tj /Span<>> BDC ( )Tj EMC (\227 0,70.)Tj /T1_3 1 Tf 2.97 -1.143 Td (Sensitivity)Tj /T1_0 1 Tf -0.175 -1.143 Td (LR)Tj /Span<>> BDC ( )Tj EMC (\227 100%,)Tj /T1_3 1 Tf 0.06 -1.143 Td (Speci\241city)Tj /T1_0 1 Tf (:)Tj -6.48 -1.143 Td (DT 91%, PPV: DT)Tj /Span<>> BDC ( )Tj EMC (\227 0,53, NPV: LGBM)Tj /Span<>> BDC ( )Tj EMC (\227 0,86,)Tj /T1_3 1 Tf 4.636 -1.143 Td (Accuracy)Tj /T1_0 1 Tf (: DT)Tj /Span<>> BDC ( )Tj EMC (\227 0,75)Tj 19.834 6.858 Td (10- \022\030\026\021\027\026\016 \022\030\024\f\f-)Tj 1.686 -1.143 Td (\r\026\035\017\007\026\006\017\016)Tj 10.804 1.143 Td (23)Tj 6.587 0 Td (1853)Tj /T1_1 1 Tf 7 0 0 7 70.866 412.6238 Tm (\t\033\022\006\016\005\037\020\022\016: \240)Tj /Span<>> BDC ( )Tj EMC (\227 \034\025\235\037\030 \036\032\201\022\036\037\016\006\034\024\035\003\ ; \210\213)Tj /Span<>> BDC ( )Tj EMC (\227 \025\016\031\033\016\007\022\b\022\036\020\037\030 \036\032\201\022\ \036\037\016\006\034\024\035\003; RF)Tj /Span<>> BDC ( )Tj EMC [(\227 \024\027\023)0.8(\005\037\004\020\032\004 \027\016\024; SVM)]TJ /Span<>> BDC ( )Tj EMC (\227 \006\037\001\022\020\037 \034\f\034\033\020\032\002 \036\016\021\035\ \034\033\034\036; LR)Tj /Span<>> BDC ( )Tj EMC (\227 )Tj 0 -1.2 TD (\027\034\013\022\024\035\022\005\016\024\021\037\030 \033\016\013\033\016\ \024\024\022\030; NB)Tj /Span<>> BDC ( )Tj EMC [(\227 \020\037\022\036\020\032\004 \025\037\004\016\024\034\036\024\021\022\ \004 \021\027\037\024\024\022\017\022\021\037)49.5(\035\034\033; D)21.1(T)]TJ /Span<>> BDC ( )Tj EMC (\227 \b\016\033\016\036\034 \033\016\001\016\020\022\004; KNN)Tj /Span<>> BDC ( )Tj EMC [(\227 \006\016\035\034\b k)32(-\025\027\022\201\037\004\001\022\002 \024\034\024\016\b\016\004; X)50(GBoost / GB / GBM / )]TJ T* [(LightGBM / L)12.1(GBM / CatBoost)]TJ /Span<>> BDC ( )Tj EMC (\227 \013\033\037\b\022\016\020\035\020\032\004 \025\023\024\035\022\020\ \013; Bagging)Tj /Span<>> BDC ( )Tj EMC [(\227 \025\023\035\024\035\033\037\f\034\036\037\030 \037\013\033\016\013\ \037\007)0.6(\022\030; Ad)26(aBoost / A)25(B)]TJ /Span<>> BDC ( )Tj EMC (\227 \037\b\037\f\035\022\036\020\032\004 \025\023\024\035\022\020\013; \ ET)Tj /Span<>> BDC ( )Tj EMC (\227 \220\021\024\035\033\016\006\037\027\003\020\034 )Tj T* [(\033\037\020\b\034\006\022\031\022\033\034\036\037\020\020\032\016 \b\016\ \033\016\036\003\030; SuperLear)-13.7(ner)]TJ /Span<>> BDC ( )Tj EMC [(\227 \037\020\024\037\006\025\027\003 SuperLear)-13.7(ner; RFE)]TJ /Span<>> BDC ( )Tj EMC (\227 \033\016\021\023\033\024\022\036\020\034\016 \022\024\021\027\026\005\ \016\020\022\016 \f\033\022\031\020\037\021\034\036; SA)Tj /Span<>> BDC ( )Tj EMC [(\227 \006\016\035\034\b \022\006\022\035\037\007\022\022 \034\035\201\022\ \013\037; A)53(NN )]TJ T* (/ NN)Tj /Span<>> BDC ( )Tj EMC (\227 \022\024\021\023\024\024\035\036\016\020\020\037\030 \020\016\004\033\ \034\020\020\037\030 \024\016\035\003; MLP)Tj /Span<>> BDC ( )Tj EMC (\227 \006\020\034\013\034\024\027\034\004\020\032\004 \f\016\033\007\016\ \f\035\033\034\020; DNN)Tj /Span<>> BDC ( )Tj EMC [(\227 \013)28.7(\027\023\025\034\021\037\030 \020\016\004\033\034\020\020\037\030 \024\016\ \035\003; BI-L)-28(STM)]TJ /Span<>> BDC ( )Tj EMC [(\227 \b\036\023\020\037\f\033\037\036\027\016\020\020\037\030 L)-28(STM-\024\016\035\003; )]TJ T* [(DeepSur)-42(v)]TJ /Span<>> BDC ( )Tj EMC [(\227 \020\016\004\033\034\020\020\037\030 \006\034\b\016\027\003 \036\032\ \201\022\036\037\016\006\034\024\035\022 DeepSur)-41.7(v)13(; DeepHit)]TJ /Span<>> BDC ( )Tj EMC [(\227 \006\020\034\013\034\024\034\025\032\035\022\004\020\037\030 \020\016\ \004\033\034\020\020\037\030 \006\034\b\016\027\003 DeepHit; Co)14(x-)38.1(Time)]TJ /Span<>> BDC ( )Tj EMC [(\227 \020\016\004\033\034\020\020\037\030 \006\034\b\016\027\003 Co)14(x-)38(Time; )]TJ T* (N-MTLR)Tj /Span<>> BDC ( )Tj EMC [(\227 \020\016\004\033\034\020\020\037\030 \006\023)39.2(\027\003)32(\035\022\031\037\b\037\005\020\037\030 \027\034\013\022\024\035\022\005\016\ \024\021\037\030 \033\016\013\033\016\024\024\022\030; L)-35.6(A)49.9(SSO)]TJ /Span<>> BDC ( )Tj EMC [(\227 L1-\033\016\013\023)39(\027\030\033\022\031\034\036\037\020\020\032\004 \034\035\025\034\033 \f\ \033\022\031\020\037\021\034\036 \(L)-35.9(A)49.9(SSO\); EN)]TJ /Span<>> BDC ( )Tj EMC (\227 \220\027\037\024\035\022\005\020\037\030 \024\016\035\021\037; )Tj T* (RSF)Tj /Span<>> BDC ( )Tj EMC (\227 \024\027\023\005\037\004\020\032\004 \027\016\024 \036\032\201\022\036\ \037\016\006\034\024\035\022; SSLR)Tj /Span<>> BDC ( )Tj EMC [(\227 \f\034\027\023-\024\023\f\016\033\036\022\031\022\033\034\036\037\020\ \020\037\030 \027\034\013\022\024\035\022\005\016\024\021\037\030 \033\016\ \013)0.7(\033\016\024\024\022\030; AFT)]TJ /Span<>> BDC ( )Tj EMC (\227 \006\034\b\016\027\003 \023\024\021\034\033\016\020\020\034\013\034\ \036\033\016\006\016\020\022 \b\034)Tj /Span<>> BDC ( )Tj EMC (\024\034\025\032\035\022\030; )Tj T* [(SMO)20(TE)]TJ /Span<>> BDC ( )Tj EMC [(\227 \037\027\013\034\033\022\035)16.1(\006 SMO)20(TE \(\024\022\020\035\016\035\022\005\016\024\021\034\016 \023\036\016\027\ \022\005\016\020\022\016 \006\037\027\034\013\034 \021\027\037\024\024\037\ \); A)29.5(UC / A)29(UR)19.1(OC)]TJ /Span<>> BDC ( )Tj EMC [(\227 \f\027\034\235\037\b\003 \f\034\b R)19(OC-\021\033\022\036\034\004; A)29(UP)66(R)21(C)]TJ /Span<>> BDC ( )Tj EMC [(\227 \f\027\034\235\037\b\003 \f\034\b P)66(R)25(-\021\033\022\036\034\004; Br)-37(ier )]TJ T* (score)Tj /Span<>> BDC ( )Tj EMC (\227 \034\001\022\025\021\037 \210\033\022\016\033\037; Precision / PPV)Tj /Span<>> BDC ( )Tj EMC [(\227 \f\034\027\034\201\022\035\016\027\003\020\037\030 \f\033\034\013\020\ \034\024\035\022\005\016\024\021\037\030 \007\016\020\020\034\024\035\003\ ; R)21.7(ecall / Sensitivity)]TJ /Span<>> BDC ( )Tj EMC [(\227 \005\023\036\024\035\036\022\035\016\027\003\020\034\024\035\003 \(\ \f\034\027\020\034\035\037\); Specif)-42.9(ic)]TJ (-)Tj T* (ity)Tj /Span<>> BDC ( )Tj EMC (\227 \024\f\016\007\022\017\022\005\020\034\024\035\003; Accuracy)Tj /Span<>> BDC ( )Tj EMC (\227 \034\025\235\037\030 \035\034\005\020\034\024\035\003; F1-score)Tj /Span<>> BDC ( )Tj EMC (\227 \024\033\016\b\020\016\016 \035\034\005\020\034\024\035\022 \022)Tj /Span<>> BDC ( )Tj EMC [(\005\023\036\024)0.7(\035\036\022\035\016\027\003\020\034\024\035\022; C-inde)-15(x)]TJ /Span<>> BDC ( )Tj EMC (\227 \022\020\b\016\021\024 \021\034\020\021\034\033\b\037\020\035\020\034\ \024\035\022; NPV)Tj /Span<>> BDC ( )Tj EMC (\227 )Tj T* [(\034\035\033\022\007\037)49.1(\035\016\027\003\020\037\030 \f\033\034\013\020\034\024\035\022\005\016\024\ \021\037\030 \007\016\020\020\034\024\035\003; HR)]TJ /Span<>> BDC ( )Tj EMC (\227 \034\035\020\034\001\016\020\022\016 \033\022\024\021\034\036; OR)Tj /Span<>> BDC ( )Tj EMC [(\227 \034\035\020\034\001\016\020\022\016 )0.7(\001\037\020\024\034\036; I\262)]TJ /Span<>> BDC ( )Tj EMC [(\227 \024\035\037)49.1(\035\022\024\035\022\021\037 \013\016\035\016\033\034\013\016\020\020\034\ \024\035\022 I-\021\036\037\b)26(\033\037)49.1(\035; \251\262)]TJ /Span<>> BDC ( )Tj EMC (\227 )Tj T* [(\006\016\201\022\024\024\027\016\b\034\036\037)49.1(\035\016\027\003\024\021\037\030 \b\022\024\f\016\033\024\022\030 \251-\021\ \036\037\b)26.2(\033\037)49(\035; Q-test)]TJ /Span<>> BDC ( )Tj EMC (\227 \035\016\024\035 \r\034\021\033\037\020\037 Q)Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\007\003\032)50(\n\n\217\n)-21(\035\030\002)]TJ 53.418 0 Td [(MET)30(A)-41(-)-41.9(ANAL)30(Y)30(SIS)]TJ -53.418 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 2)69(4, \023\0224, 202)23(5)]TJ 43.013 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 2)69(4, \023\0224, 202)23(5)]TJ /T1_5 1 Tf 25 0 0 25 20.7527 56.0378 Tm (132)Tj ET endstream endobj 1498 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\030\b\017\200\b\b)-9.9(\026\r\016\215\215\220\207 \021\215\026)11.1(\016\t\t\016\017)-10(\026 \211)-20.9(\t\004 \222\201\025\202\215\025)21(\213\021\201\025\r\001\215\021\004 )]TJ 0 -1 TD [(\025\026)11(\211\001\t\016\215\215\220 \201\016\213)21(\200\t\214)21(\026)11(\001\026)11(\025\r \t\016\f\016\215\021\004 \235\025\t\214\215\220 \017)10(\025\t\025\201\016\017)-9.9(\026)11(\001\t\214\215\220\024 )]TJ T* [(\201\001\017)10(\025\024 \(\b\021\b)-10(\026)11(\016\024\001\026\021\f\016\b\017\021\207 \025\235\213\025\201 \021\022\024\ \016\026)11(\001\001\215\001\t\021\213\))]TJ 34.456 2 Td [(Ar)-20(tif)-21(icial intelligence for pr)31(edicting long-term outcomes in patients )]TJ 1.361 -1 Td [(with color)31(ectal cancer \(a\022s)10(y)10(stematic r)31(e)11(vie)11(w and meta-analy)10(sis\))]TJ ET 0 0 0 1 K 0.5 w /GS1 gs q 1 0 0 1 42.5197 736.7579 cm 0 0 m 42.77 0 l S Q q 1 0 0 1 42.7697 710.2637 cm 0 0 m 0 26.244 l S Q q 1 0 0 1 85.2894 736.7579 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 85.2894 710.2637 cm 0 0 m 0 26.244 l S Q q 1 0 0 1 130.6437 736.7579 cm 0 0 m 68.031 0 l S Q q 1 0 0 1 130.6437 710.2637 cm 0 0 m 0 26.244 l S Q q 1 0 0 1 198.6752 736.7579 cm 0 0 m 158.74 0 l S Q q 1 0 0 1 198.6752 710.2637 cm 0 0 m 0 26.244 l S Q q 1 0 0 1 357.4153 736.7579 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 357.4153 710.2637 cm 0 0 m 0 26.244 l S Q q 1 0 0 1 416.9429 736.7579 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 416.9429 710.2637 cm 0 0 m 0 26.244 l S Q q 1 0 0 1 459.4626 736.7579 cm 0 0 m 37.1 0 l S Q q 1 0 0 1 459.4626 710.2637 cm 0 0 m 0 26.244 l S Q q 1 0 0 1 496.313 710.2637 cm 0 0 m 0 26.244 l S Q q 1 0 0 1 42.5197 710.0137 cm 0 0 m 42.77 0 l S Q q 1 0 0 1 42.7697 659.5264 cm 0 0 m 0 50.237 l S Q q 1 0 0 1 85.2894 710.0137 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 85.2894 659.5264 cm 0 0 m 0 50.237 l S Q q 1 0 0 1 130.6437 710.0137 cm 0 0 m 68.031 0 l S Q q 1 0 0 1 130.6437 659.5264 cm 0 0 m 0 50.237 l S Q q 1 0 0 1 198.6752 710.0137 cm 0 0 m 158.74 0 l S Q q 1 0 0 1 198.6752 659.5264 cm 0 0 m 0 50.237 l S Q q 1 0 0 1 357.4153 710.0137 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 357.4153 659.5264 cm 0 0 m 0 50.237 l S Q q 1 0 0 1 416.9429 710.0137 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 416.9429 659.5264 cm 0 0 m 0 50.237 l S Q q 1 0 0 1 459.4626 710.0137 cm 0 0 m 37.1 0 l S Q q 1 0 0 1 459.4626 659.5264 cm 0 0 m 0 50.237 l S Q q 1 0 0 1 496.313 659.5264 cm 0 0 m 0 50.237 l S Q q 1 0 0 1 42.5197 659.2764 cm 0 0 m 42.77 0 l S Q q 1 0 0 1 42.7697 632.7891 cm 0 0 m 0 26.237 l S Q q 1 0 0 1 85.2894 659.2764 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 85.2894 632.7891 cm 0 0 m 0 26.237 l S Q q 1 0 0 1 130.6437 659.2764 cm 0 0 m 68.031 0 l S Q q 1 0 0 1 130.6437 632.7891 cm 0 0 m 0 26.237 l S Q q 1 0 0 1 198.6752 659.2764 cm 0 0 m 158.74 0 l S Q q 1 0 0 1 198.6752 632.7891 cm 0 0 m 0 26.237 l S Q q 1 0 0 1 357.4153 659.2764 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 357.4153 632.7891 cm 0 0 m 0 26.237 l S Q q 1 0 0 1 416.9429 659.2764 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 416.9429 632.7891 cm 0 0 m 0 26.237 l S Q q 1 0 0 1 459.4626 659.2764 cm 0 0 m 37.1 0 l S Q q 1 0 0 1 459.4626 632.7891 cm 0 0 m 0 26.237 l S Q q 1 0 0 1 496.313 632.7891 cm 0 0 m 0 26.237 l S Q q 1 0 0 1 42.5197 632.5391 cm 0 0 m 42.77 0 l S Q q 1 0 0 1 42.7697 582.0518 cm 0 0 m 0 50.237 l S Q q 1 0 0 1 85.2894 632.5391 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 85.2894 582.0518 cm 0 0 m 0 50.237 l S Q q 1 0 0 1 130.6437 632.5391 cm 0 0 m 68.031 0 l S Q q 1 0 0 1 130.6437 582.0518 cm 0 0 m 0 50.237 l S Q q 1 0 0 1 198.6752 632.5391 cm 0 0 m 158.74 0 l S Q q 1 0 0 1 198.6752 582.0518 cm 0 0 m 0 50.237 l S Q q 1 0 0 1 357.4153 632.5391 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 357.4153 582.0518 cm 0 0 m 0 50.237 l S Q q 1 0 0 1 416.9429 632.5391 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 416.9429 582.0518 cm 0 0 m 0 50.237 l S Q q 1 0 0 1 459.4626 632.5391 cm 0 0 m 37.1 0 l S Q q 1 0 0 1 459.4626 582.0518 cm 0 0 m 0 50.237 l S Q q 1 0 0 1 496.313 582.0518 cm 0 0 m 0 50.237 l S Q q 1 0 0 1 42.5197 581.8018 cm 0 0 m 42.77 0 l S Q q 1 0 0 1 42.7697 515.3076 cm 0 0 m 0 66.244 l S Q q 1 0 0 1 85.2894 581.8018 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 85.2894 515.3076 cm 0 0 m 0 66.244 l S Q q 1 0 0 1 130.6437 581.8018 cm 0 0 m 68.031 0 l S Q q 1 0 0 1 130.6437 515.3076 cm 0 0 m 0 66.244 l S Q q 1 0 0 1 198.6752 581.8018 cm 0 0 m 158.74 0 l S Q q 1 0 0 1 198.6752 515.3076 cm 0 0 m 0 66.244 l S Q q 1 0 0 1 357.4153 581.8018 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 357.4153 515.3076 cm 0 0 m 0 66.244 l S Q q 1 0 0 1 416.9429 581.8018 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 416.9429 515.3076 cm 0 0 m 0 66.244 l S Q q 1 0 0 1 459.4626 581.8018 cm 0 0 m 37.1 0 l S Q q 1 0 0 1 459.4626 515.3076 cm 0 0 m 0 66.244 l S Q q 1 0 0 1 496.313 515.3076 cm 0 0 m 0 66.244 l S Q q 1 0 0 1 42.5197 515.0576 cm 0 0 m 42.77 0 l S Q q 1 0 0 1 42.7697 448.5703 cm 0 0 m 0 66.237 l S Q q 1 0 0 1 85.2894 515.0576 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 85.2894 448.5703 cm 0 0 m 0 66.237 l S Q q 1 0 0 1 130.6437 515.0576 cm 0 0 m 68.031 0 l S Q q 1 0 0 1 130.6437 448.5703 cm 0 0 m 0 66.237 l S Q q 1 0 0 1 198.6752 515.0576 cm 0 0 m 158.74 0 l S Q q 1 0 0 1 198.6752 448.5703 cm 0 0 m 0 66.237 l S Q q 1 0 0 1 357.4153 515.0576 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 357.4153 448.5703 cm 0 0 m 0 66.237 l S Q q 1 0 0 1 416.9429 515.0576 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 416.9429 448.5703 cm 0 0 m 0 66.237 l S Q q 1 0 0 1 459.4626 515.0576 cm 0 0 m 37.1 0 l S Q q 1 0 0 1 459.4626 448.5703 cm 0 0 m 0 66.237 l S Q q 1 0 0 1 496.313 448.5703 cm 0 0 m 0 66.237 l S Q q 1 0 0 1 42.5197 448.3203 cm 0 0 m 42.77 0 l S Q q 1 0 0 1 42.7697 413.833 cm 0 0 m 0 34.237 l S Q q 1 0 0 1 85.2894 448.3203 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 85.2894 413.833 cm 0 0 m 0 34.237 l S Q q 1 0 0 1 130.6437 448.3203 cm 0 0 m 68.031 0 l S Q q 1 0 0 1 130.6437 413.833 cm 0 0 m 0 34.237 l S Q q 1 0 0 1 198.6752 448.3203 cm 0 0 m 158.74 0 l S Q q 1 0 0 1 198.6752 413.833 cm 0 0 m 0 34.237 l S Q q 1 0 0 1 357.4153 448.3203 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 357.4153 413.833 cm 0 0 m 0 34.237 l S Q q 1 0 0 1 416.9429 448.3203 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 416.9429 413.833 cm 0 0 m 0 34.237 l S Q q 1 0 0 1 459.4626 448.3203 cm 0 0 m 37.1 0 l S Q q 1 0 0 1 459.4626 413.833 cm 0 0 m 0 34.237 l S Q q 1 0 0 1 496.313 413.833 cm 0 0 m 0 34.237 l S Q q 1 0 0 1 42.5197 413.583 cm 0 0 m 42.77 0 l S Q q 1 0 0 1 42.7697 387.0957 cm 0 0 m 0 26.237 l S Q q 1 0 0 1 85.2894 413.583 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 85.2894 387.0957 cm 0 0 m 0 26.237 l S Q q 1 0 0 1 130.6437 413.583 cm 0 0 m 68.031 0 l S Q q 1 0 0 1 130.6437 387.0957 cm 0 0 m 0 26.237 l S Q q 1 0 0 1 198.6752 413.583 cm 0 0 m 158.74 0 l S Q q 1 0 0 1 198.6752 387.0957 cm 0 0 m 0 26.237 l S Q q 1 0 0 1 357.4153 413.583 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 357.4153 387.0957 cm 0 0 m 0 26.237 l S Q q 1 0 0 1 416.9429 413.583 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 416.9429 387.0957 cm 0 0 m 0 26.237 l S Q q 1 0 0 1 459.4626 413.583 cm 0 0 m 37.1 0 l S Q q 1 0 0 1 459.4626 387.0957 cm 0 0 m 0 26.237 l S Q q 1 0 0 1 496.313 387.0957 cm 0 0 m 0 26.237 l S Q q 1 0 0 1 42.5197 386.8457 cm 0 0 m 42.77 0 l S Q q 1 0 0 1 42.7697 320.3515 cm 0 0 m 0 66.244 l S Q q 1 0 0 1 85.2894 386.8457 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 85.2894 320.3515 cm 0 0 m 0 66.244 l S Q q 1 0 0 1 130.6437 386.8457 cm 0 0 m 68.031 0 l S Q q 1 0 0 1 130.6437 320.3515 cm 0 0 m 0 66.244 l S Q q 1 0 0 1 198.6752 386.8457 cm 0 0 m 158.74 0 l S Q q 1 0 0 1 198.6752 320.3515 cm 0 0 m 0 66.244 l S Q q 1 0 0 1 357.4153 386.8457 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 357.4153 320.3515 cm 0 0 m 0 66.244 l S Q q 1 0 0 1 416.9429 386.8457 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 416.9429 320.3515 cm 0 0 m 0 66.244 l S Q q 1 0 0 1 459.4626 386.8457 cm 0 0 m 37.1 0 l S Q q 1 0 0 1 459.4626 320.3515 cm 0 0 m 0 66.244 l S Q q 1 0 0 1 496.313 320.3515 cm 0 0 m 0 66.244 l S Q q 1 0 0 1 42.5197 320.1015 cm 0 0 m 42.77 0 l S Q q 1 0 0 1 42.7697 301.6142 cm 0 0 m 0 18.237 l S Q q 1 0 0 1 85.2894 320.1015 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 85.2894 301.6142 cm 0 0 m 0 18.237 l S Q q 1 0 0 1 130.6437 320.1015 cm 0 0 m 68.031 0 l S Q q 1 0 0 1 130.6437 301.6142 cm 0 0 m 0 18.237 l S Q q 1 0 0 1 198.6752 320.1015 cm 0 0 m 158.74 0 l S Q q 1 0 0 1 198.6752 301.6142 cm 0 0 m 0 18.237 l S Q q 1 0 0 1 357.4153 320.1015 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 357.4153 301.6142 cm 0 0 m 0 18.237 l S Q q 1 0 0 1 416.9429 320.1015 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 416.9429 301.6142 cm 0 0 m 0 18.237 l S Q q 1 0 0 1 459.4626 320.1015 cm 0 0 m 37.1 0 l S Q q 1 0 0 1 459.4626 301.6142 cm 0 0 m 0 18.237 l S Q q 1 0 0 1 496.313 301.6142 cm 0 0 m 0 18.237 l S Q q 1 0 0 1 42.5197 301.3642 cm 0 0 m 42.77 0 l S Q q 1 0 0 1 42.7697 258.87 cm 0 0 m 0 42.244 l S Q q 1 0 0 1 85.2894 301.3642 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 85.2894 258.87 cm 0 0 m 0 42.244 l S Q q 1 0 0 1 130.6437 301.3642 cm 0 0 m 68.031 0 l S Q q 1 0 0 1 130.6437 258.87 cm 0 0 m 0 42.244 l S Q q 1 0 0 1 198.6752 301.3642 cm 0 0 m 158.74 0 l S Q q 1 0 0 1 198.6752 258.87 cm 0 0 m 0 42.244 l S Q q 1 0 0 1 357.4153 301.3642 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 357.4153 258.87 cm 0 0 m 0 42.244 l S Q q 1 0 0 1 416.9429 301.3642 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 416.9429 258.87 cm 0 0 m 0 42.244 l S Q q 1 0 0 1 459.4626 301.3642 cm 0 0 m 37.1 0 l S Q q 1 0 0 1 459.4626 258.87 cm 0 0 m 0 42.244 l S Q q 1 0 0 1 496.313 258.87 cm 0 0 m 0 42.244 l S Q q 1 0 0 1 42.5197 258.62 cm 0 0 m 42.77 0 l S Q q 1 0 0 1 42.7697 224.1327 cm 0 0 m 0 34.237 l S Q q 1 0 0 1 85.2894 258.62 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 85.2894 224.1327 cm 0 0 m 0 34.237 l S Q q 1 0 0 1 130.6437 258.62 cm 0 0 m 68.031 0 l S Q q 1 0 0 1 130.6437 224.1327 cm 0 0 m 0 34.237 l S Q q 1 0 0 1 198.6752 258.62 cm 0 0 m 158.74 0 l S Q q 1 0 0 1 198.6752 224.1327 cm 0 0 m 0 34.237 l S Q q 1 0 0 1 357.4153 258.62 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 357.4153 224.1327 cm 0 0 m 0 34.237 l S Q q 1 0 0 1 416.9429 258.62 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 416.9429 224.1327 cm 0 0 m 0 34.237 l S Q q 1 0 0 1 459.4626 258.62 cm 0 0 m 37.1 0 l S Q q 1 0 0 1 459.4626 224.1327 cm 0 0 m 0 34.237 l S Q q 1 0 0 1 496.313 224.1327 cm 0 0 m 0 34.237 l S Q q 1 0 0 1 42.5197 223.8827 cm 0 0 m 42.77 0 l S Q q 1 0 0 1 42.7697 173.3954 cm 0 0 m 0 50.237 l S Q q 1 0 0 1 85.2894 223.8827 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 85.2894 173.3954 cm 0 0 m 0 50.237 l S Q q 1 0 0 1 130.6437 223.8827 cm 0 0 m 68.031 0 l S Q q 1 0 0 1 130.6437 173.3954 cm 0 0 m 0 50.237 l S Q q 1 0 0 1 198.6752 223.8827 cm 0 0 m 158.74 0 l S Q q 1 0 0 1 198.6752 173.3954 cm 0 0 m 0 50.237 l S Q q 1 0 0 1 357.4153 223.8827 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 357.4153 173.3954 cm 0 0 m 0 50.237 l S Q q 1 0 0 1 416.9429 223.8827 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 416.9429 173.3954 cm 0 0 m 0 50.237 l S Q q 1 0 0 1 459.4626 223.8827 cm 0 0 m 37.1 0 l S Q q 1 0 0 1 459.4626 173.3954 cm 0 0 m 0 50.237 l S Q q 1 0 0 1 496.313 173.3954 cm 0 0 m 0 50.237 l S Q q 1 0 0 1 42.5197 173.1454 cm 0 0 m 42.77 0 l S Q q 1 0 0 1 42.7697 154.6581 cm 0 0 m 0 18.237 l S Q q 1 0 0 1 85.2894 173.1454 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 85.2894 154.6581 cm 0 0 m 0 18.237 l S Q q 1 0 0 1 130.6437 173.1454 cm 0 0 m 68.031 0 l S Q q 1 0 0 1 130.6437 154.6581 cm 0 0 m 0 18.237 l S Q q 1 0 0 1 198.6752 173.1454 cm 0 0 m 158.74 0 l S Q q 1 0 0 1 198.6752 154.6581 cm 0 0 m 0 18.237 l S Q q 1 0 0 1 357.4153 173.1454 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 357.4153 154.6581 cm 0 0 m 0 18.237 l S Q q 1 0 0 1 416.9429 173.1454 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 416.9429 154.6581 cm 0 0 m 0 18.237 l S Q q 1 0 0 1 459.4626 173.1454 cm 0 0 m 37.1 0 l S Q q 1 0 0 1 459.4626 154.6581 cm 0 0 m 0 18.237 l S Q q 1 0 0 1 496.313 154.6581 cm 0 0 m 0 18.237 l S Q q 1 0 0 1 42.5197 154.4081 cm 0 0 m 42.77 0 l S Q q 1 0 0 1 42.7697 135.9208 cm 0 0 m 0 18.237 l S Q q 1 0 0 1 85.2894 154.4081 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 85.2894 135.9208 cm 0 0 m 0 18.237 l S Q q 1 0 0 1 130.6437 154.4081 cm 0 0 m 68.031 0 l S Q q 1 0 0 1 130.6437 135.9208 cm 0 0 m 0 18.237 l S Q q 1 0 0 1 198.6752 154.4081 cm 0 0 m 158.74 0 l S Q q 1 0 0 1 198.6752 135.9208 cm 0 0 m 0 18.237 l S Q q 1 0 0 1 357.4153 154.4081 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 357.4153 135.9208 cm 0 0 m 0 18.237 l S Q q 1 0 0 1 416.9429 154.4081 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 416.9429 135.9208 cm 0 0 m 0 18.237 l S Q q 1 0 0 1 459.4626 154.4081 cm 0 0 m 37.1 0 l S Q q 1 0 0 1 459.4626 135.9208 cm 0 0 m 0 18.237 l S Q q 1 0 0 1 496.313 135.9208 cm 0 0 m 0 18.237 l S Q q 1 0 0 1 42.5197 135.6708 cm 0 0 m 42.77 0 l S Q q 1 0 0 1 85.2894 135.6708 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 130.6437 135.6708 cm 0 0 m 68.031 0 l S Q q 1 0 0 1 198.6752 135.6708 cm 0 0 m 158.74 0 l S Q q 1 0 0 1 357.4153 135.6708 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 416.9429 135.6708 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 459.4626 135.6708 cm 0 0 m 37.1 0 l S Q BT 0 0 0 1 k /GS2 gs /T1_1 1 Tf 5.6 0 0 7 51.2869 720.8483 Tm (\032\003\002\006, \n\002\240)Tj 8.046 0 Td (\032\f\n\002\006\t\003\214)Tj 6.778 0.571 Td (\200\006\002\n\b\002\213\t\006\210\r\214\013\005 \220\f\t\b\t)Tj 5.6 0 0 7 192.9475 724.8483 Tm (-)Tj 5.6 0 0 7 148.4477 716.8483 Tm (\201\r\217\220\t\005 \t\217\216\002\240)Tj 20.633 0.571 Td (\022\r\213\210\f\001\003\004\003\013)Tj 18.177 0 Td 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RF)Tj 7.072 8 Td (1-, 2-, 3-, 4-, 5-\035\036\021\027\016\016 \210\200)Tj /T1_1 1 Tf 22.607 -0.001 Td (5-\f\r\003\b\235\235 \017\026)Tj -1.355 -1.143 Td (\017\206\002\240\002\201\b\004\235 \220\t\232\220\004:)Tj /T1_2 1 Tf 0.534 -1.143 Td (Accuracy 96,45%,)Tj 1.312 -1.143 Td (AUC 0,985;)Tj /T1_1 1 Tf -1.134 -1.143 Td (\200\006\235\214\004\235 \220\t\232\220\004:)Tj /T1_2 1 Tf -0.178 -1.143 Td (\202ccuracy 94,51%,)Tj 1.319 -1.143 Td (AUC 0,971.)Tj 17.773 6.858 Td (10- \022\030\026\021\027\026\016 \022\030\024\f\f-)Tj 1.686 -1.143 Td (\r\026\035\017\007\026\006\017\016)Tj 10.804 1.143 Td (61)Tj 6.337 0 Td (27795)Tj -75.943 -9.534 Td (Qiu, Binxu et al., )Tj T* (2022 [26])Tj 8.27 1.143 Td (RF, LGBM, XGB, )Tj 0.827 -1.143 Td (multilayer )Tj -0.149 -1.143 Td (perceptron )Tj -0.744 -1.143 Td (\(MLP\), LR, KNN)Tj 9.238 3.429 Td (\204\036\021\026\f\021\026\017\030\024\r\026\027\017\036 )Tj 2.037 -1.143 Td (\r)Tj /Span<>> BDC ( )Tj EMC (\023\036\004\036\027\034)Tj 21.099 1.143 Td (XGB:)Tj -12.514 -1.143 Td (AUC)Tj /Span<>> BDC ( )Tj EMC (\227 0,926, accuracy)Tj /Span<>> BDC ( )Tj EMC (\227 0,919, sensitivity)Tj /Span<>> BDC ( )Tj EMC (\227 0,740, speci\251city)Tj /Span<>> BDC ( )Tj EMC (\227 )Tj 12.351 -1.143 Td (0,765)Tj 16.701 2.286 Td (10- \022\030\026\021\027\026\016 \022\030\024\f\f-)Tj 1.686 -1.143 Td (\r\026\035\017\007\026\006\017\016)Tj 10.804 1.143 Td (11)Tj 6.337 0 Td (20882)Tj -75.943 -4.962 Td (Liu, Yuan et al., )Tj 0 -1.143 TD (2024 [27])Tj 7.682 1.143 Td (XGBoost, RF, SVM, )Tj 2.606 -1.143 Td (KNN)Tj 7.153 1.143 Td (\204\036\021\026\f\021\026\017\030\024\r\026\027\017\036 )Tj 2.037 -1.143 Td (\r)Tj /Span<>> BDC ( )Tj EMC (\023\036\004\036\027\034)Tj 20.228 1.143 Td (XGBoost:)Tj -11.596 -1.143 Td (AUC 0,922)Tj /Span<>> BDC ( )Tj EMC (\(0,833\2260,995\), accuracy 0,908)Tj /Span<>> BDC ( )Tj EMC (\(0,889\2260,926\), sensitivity )Tj 2.925 -1.143 Td (0,924)Tj /Span<>> BDC ( )Tj EMC (\(0,873\2260,975\), speci\251city 0,883)Tj /Span<>> BDC ( )Tj EMC 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-1.238 -1.143 Td (0,889)Tj /Span<>> BDC ( )Tj EMC (\(95%\212\236 0,812\2260,966\);)Tj -1.475 -1.143 Td (C-index 0,862)Tj /Span<>> BDC ( )Tj EMC (\(95%\212\236 0,818\2260,906\))Tj 22.517 8.001 Td (Internal and external )Tj 2.222 -1.143 Td (validation)Tj 10.64 1.143 Td (17)Tj 6.837 0 Td (356)Tj -76.443 -9.535 Td (Qiu, Binxu et al., )Tj 0 -1.143 TD (2023 [29])Tj 10.354 1.143 Td (XGB)Tj 8.493 0 Td (\210\021\007\026\035\036\027\027\024\036 )Tj -1.358 -1.143 Td (\n\036\021\026\f\021\026\017\030\024\r\026\027\017\036)Tj 13.951 1.143 Td (AUC)Tj /Span<>> BDC ( )Tj EMC (\227 0,814; AUPRC)Tj /Span<>> BDC ( )Tj EMC (\227 0,609; accuracy)Tj /Span<>> BDC ( )Tj EMC (\227 0,800;)Tj 6.398 -1.143 Td (precision)Tj /Span<>> BDC ( )Tj EMC (\227 0,810)Tj 19.278 1.143 Td (10- \022\030\026\021\027\026\016 \022\030\024\f\f-)Tj 1.686 -1.143 Td (\r\026\035\017\007\026\006\017\016)Tj 10.804 1.143 Td (12)Tj 6.337 0 Td (25045)Tj -75.943 -2.677 Td (Xing Y. et al., )Tj 0 -1.143 TD (2024 [30])Tj 7.927 1.143 Td (XGB, 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(RF, Recursive )Tj 1.103 -1.143 Td (Feature )Tj -0.915 -1.143 Td (Elimination, )Tj 0.445 -1.143 Td (simulated )Tj -1.136 -1.143 Td (annealing, SVM, )Tj 1.611 -1.143 Td (DT, XGB)Tj 9.774 5.714 Td (\210\200 \017)Tj /Span<>> BDC ( )Tj EMC (\207\217\200)Tj /T1_1 1 Tf 9.077 -0.001 Td (\200\006\002\n\b\002\213\t\006\002\004\b\t\r \006\r\204\t\240\t\004:)Tj /T1_2 1 Tf ( Sensitivity)Tj /Span<>> BDC ( )Tj EMC (\227 75%, speci\251city)Tj /Span<>> BDC ( )Tj EMC (\227 )Tj 11.705 -1.143 Td (75,7%,)Tj -1.474 -1.143 Td (AUC)Tj /Span<>> BDC ( )Tj EMC (\227 0,666;)Tj /T1_1 1 Tf -10.447 -1.143 Td (\200\006\002\n\b\002\213\t\006\002\004\b\t\r \017\026:)Tj /T1_2 1 Tf ( sensitivity)Tj /Span<>> BDC ( )Tj EMC (\227 80,5%, speci\251city)Tj /Span<>> BDC ( )Tj EMC (\227 64,8%,)Tj 10.603 -1.143 Td (AUC)Tj /Span<>> BDC ( )Tj EMC (\227 0,630)Tj 17.563 4.572 Td (K)Tj /Span<>> BDC (-)Tj EMC (fold cross)Tj /Span<>> BDC (-)Tj EMC (validation)Tj 13.42 0 Td (8)Tj 6.587 0 Td (200)Tj -76.443 -7.248 Td (Tian, Yu et al., )Tj T* (2018 [33])Tj 8.152 1.143 Td (Cox regression, )Tj 0.238 -1.143 Td (AFT model, RF)Tj 12.319 1.143 Td (\210\200)Tj 15.126 0 Td (C-index 0,898)Tj /Span<>> BDC ( )Tj EMC (\(0,895\2260,902\))Tj 21.574 0 Td (\025\030\024\f\f-\r\026\035\017\007\026\006\017\016)Tj 12.448 0 Td (9)Tj 5.837 0 Td (128061)Tj -75.693 -2.677 Td (Wei R. et al., )Tj T* (2024 [34])Tj 8.084 1.143 Td (RF, LR, XGB, NN, )Tj 2.204 -1.143 Td (KNN)Tj 8.559 1.143 Td (\210\021\007\026\035\036\027\027\024\036 )Tj -1.358 -1.143 Td (\n\036\021\026\f\021\026\017\030\024\r\026\027\017\036)Tj 23.541 1.143 Td (RF)Tj -2.156 -1.143 Td (AUC)Tj /Span<>> BDC ( )Tj EMC (\227 0,843)Tj 18.535 1.143 Td (\025\030\024\f\f-\r\026\035\017\007\026\006\017\016)Tj 12.198 0 Td (15)Tj 6.087 0 Td (200958)Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\007\003\032)50(\n\n\217\n)-21(\035\030\002)]TJ 53.418 0 Td [(MET)30(A)-41(-)-41.9(ANAL)30(Y)30(SIS)]TJ /T1_3 1 Tf 25 0 0 25 504.6396 56.0378 Tm (131)Tj ET endstream endobj 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/Span<>> BDC ( )Tj EMC (\227 0,854; LGBM)Tj /Span<>> BDC ( )Tj EMC (\227 0,868; )Tj 8.256 -1.143 Td (XGBoost)Tj /Span<>> BDC ( )Tj EMC (\227 0,855.)Tj 19.485 4.572 Td (5- \022\030\026\021\027\026\016 \022\030\024\f\f-)Tj -0.966 -1.143 Td (\r\026\035\017\007\026\006\017\016)Tj /Span<>> BDC ( )Tj EMC (+)Tj /Span<>> BDC ( )Tj EMC (train-test )Tj 3.705 -1.143 Td (split)Tj 9.752 2.286 Td (7)Tj 6.337 0 Td (1236)Tj -76.193 -6.106 Td (Gupta et al., )Tj T* (2019 [9])Tj 8.849 1.143 Td (RF, SVM, LR, )Tj 0.276 -1.143 Td (Multilayer )Tj -0.273 -1.143 Td (Perceptron, )Tj -0.728 -1.143 Td (K-NN, Adaptive )Tj 1.221 -1.143 Td (Boosting)Tj 11.11 4.571 Td (\207\217\200)Tj /T1_0 1 Tf 20.046 -0.001 Td (AUC)Tj /T1_1 1 Tf (:)Tj -10.66 -1.143 Td (RF)Tj /Span<>> BDC ( )Tj EMC (\227 0,82)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (0,10; SVM)Tj /Span<>> BDC ( )Tj EMC (\227 0,77)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (0,03; Logistic Regression: )Tj 9.344 -1.143 Td (0,76)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (0,02;)Tj -9.28 -1.143 Td (MLP)Tj /Span<>> BDC ( )Tj EMC (\227 0,78)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (0,11; KNN)Tj /Span<>> BDC ( )Tj EMC (\227 0,75)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (0,06; AB)Tj /Span<>> BDC ( )Tj EMC (\227 0,77)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (0,03.)Tj /T1_0 1 Tf 9.579 -1.143 Td (Accuracy:)Tj /T1_1 1 Tf -11.126 -1.143 Td (RF)Tj /Span<>> BDC ( )Tj EMC (\227 84%; SVM)Tj /Span<>> BDC ( )Tj EMC (\227 77%; Logistic Regression)Tj /Span<>> BDC ( )Tj EMC (\227 76%; ML)Tj /Span<>> BDC ( )Tj EMC (\227 78%; )Tj 10.535 -1.143 Td (KNN)Tj /Span<>> BDC ( )Tj EMC (\227 75%;)Tj -2.834 -1.143 Td (Adaptive Boosting)Tj /Span<>> BDC ( )Tj EMC (\227 77%.)Tj 21.309 8.001 Td (5- \022\030\026\021\027\026\016 \022\030\024\f\f-)Tj -0.966 -1.143 Td (\r\026\035\017\007\026\006\017\016)Tj /Span<>> BDC ( )Tj EMC (+)Tj /Span<>> BDC ( )Tj EMC (train-test )Tj 3.705 -1.143 Td (split)Tj 9.502 2.286 Td (12)Tj 6.587 0 Td (4021)Tj -76.193 -9.535 Td (Hu et al., 2023 )Tj T* ([10])Tj 8.826 1.143 Td (DT, RF, SVM, )Tj -0.036 -1.143 Td (XGBoost, LR)Tj 10.725 1.143 Td (\217\036\006\017\007\017\r)Tj /T1_0 1 Tf 20.985 -0.001 Td (AUC:)Tj /T1_1 1 Tf -10.874 -1.143 Td (Decision Tree)Tj /Span<>> BDC ( )Tj EMC (\227 0,72; Random Forest)Tj /Span<>> BDC ( )Tj EMC (\227 0,97; SVM)Tj /Span<>> BDC ( )Tj EMC (\227 0,89; )Tj 8.505 -1.143 Td (XGBoost)Tj /Span<>> BDC ( )Tj EMC (\227 0,94.)Tj /T1_0 1 Tf 0.963 -1.143 Td (Sensitivity)Tj /T1_1 1 Tf (:)Tj -6.848 -1.143 Td (\(\205\017\027\026\035\034\027\026\016 \n\024\007\036\035\034, \230\036\f\ \021\024\r\026\016 \r\t\002\024\030\022\026\): 94%)Tj -2.558 -1.143 Td (Speci\251city \(\205\017\027\026\035\034\027\026\016 \n\024\007\036\035\034\ , \230\036\f\021\024\r\026\016 \r\t\002\024\030\022\026\): 86,2%)Tj -0.035 -1.143 Td (Sensitivity \(\205\017\027\026\035\034\027\026\016 \n\024\007\036\035\034\ , \230\036\f\021\024\r\026\016 \r\t\002\024\030\022\026\): 94,4%)Tj 0.183 -1.143 Td (Speci\251city \(\205\017\027\026\035\034\027\026\016 \n\024\007\036\035\034\ , \230\036\f\021\024\r\026\016 \r\t\002\024\030\022\026\) 66,7%)Tj 27.28 8.001 Td (10- \022\030\026\021\027\026\016 \022\030\024\f\f-)Tj -0.716 -1.143 Td (\r\026\035\017\007\026\006\017\016)Tj /Span<>> BDC ( )Tj EMC (+)Tj /Span<>> BDC ( )Tj EMC (train-test )Tj 3.705 -1.143 Td (split)Tj 9.502 2.286 Td (12)Tj 6.837 0 Td (272)Tj -76.443 -9.535 Td (Leonard G, et )Tj T* (al., 2022 [11])Tj 8.706 1.143 Td (RF, XGBoost, )Tj -0.228 -1.143 Td (XGBoost with )Tj 0.649 -1.143 Td (SMOTE, LR)Tj 9.806 2.286 Td (\224\n\036\030\021\027\024\f\021\034)Tj /T1_0 1 Tf 21.567 -0.001 Td (AUC:)Tj /T1_1 1 Tf -9.236 -1.143 Td (Logistic Regression- 0,730)Tj /Span<>> BDC ( )Tj EMC (\(95% \212\236: 0,725\2260,735\);)Tj 0.926 -1.143 Td (Random Forest- 0,757)Tj /Span<>> BDC ( )Tj EMC (\(95% \212\236: 0,752\2260,762\);)Tj -3.079 -1.143 Td (XGBoost- 0,756)Tj /Span<>> BDC ( )Tj EMC (\(95% \212\236: 0,751\2260,761\); XGBoost with SMOTE- )Tj 6.335 -1.143 Td (0,748)Tj /Span<>> BDC ( )Tj EMC (\(95% \212\236: 0,743\2260,753\).)Tj 22.477 4.572 Td (Train-Test Split)Tj 11.684 0 Td (30)Tj 6.087 0 Td (528060)Tj -75.693 -6.106 Td (Nopour, 2024 )Tj 0 -1.143 TD ([12])Tj 8.088 1.143 Td (Random Forest, )Tj 1.303 -1.143 Td (XGBoost, )Tj -1.707 -1.143 Td (Bagging, Logistic )Tj 0.16 -1.143 Td (Regression, SVM, )Tj 0.504 -1.143 Td (ANN, Decision )Tj 0.876 -1.143 Td (Tree, KNN)Tj 9.554 5.714 Td (5-\035\036\021\027\016\016 \210\200)Tj /T1_0 1 Tf 21.722 -0.001 Td (AUC:)Tj /T1_1 1 Tf -11.08 -1.143 Td (XGBoost: 0,906)Tj /Span<>> BDC ( )Tj EMC (\(internal\), 0,813)Tj /Span<>> BDC ( )Tj EMC (\(external\) \(\035\031\004\001\026\016 \n\024\007\036\035\034\))Tj 7.775 -1.143 Td (Random Forest: 0,825)Tj 1.302 -1.143 Td (Bagging: 0,883)Tj 0.838 -1.143 Td (SVM: 0,815)Tj -0.051 -1.143 Td (ANN: 0,724)Tj -1.818 -1.143 Td (Decision Tree: 0,726)Tj 1.836 -1.143 Td (KNN: 0,786)Tj -3.034 -1.143 Td (Logistic Regression: 0,727)Tj 20.965 9.144 Td (10-\022\030\026\021\027\026\016 \022\030\024\f\f-)Tj -0.556 -1.143 Td (\r\026\035\017\007\026\006\017\016)Tj /Span<>> BDC ( )Tj EMC (+)Tj /Span<>> BDC ( )Tj EMC (external )Tj 2.29 -1.143 Td (validation)Tj 10.64 2.286 Td (12)Tj 6.587 0 Td (1062)Tj -76.193 -10.678 Td (Ji et al., 2024 )Tj 0 -1.143 TD ([13])Tj 9.893 1.143 Td (Linear )Tj -1.025 -1.143 Td (Regression, )Tj 1.025 -1.143 Td (Linear )Tj -1.31 -1.143 Td (Discriminant )Tj -0.938 -1.143 Td (Analysis, eXtreme )Tj 0.957 -1.143 Td (GB, CatBoost)Tj 8.86 5.714 Td (\210\200, \207\217\200 \017)Tj /Span<>> BDC ( )Tj EMC (\030\036\006\017\007\017\r)Tj /T1_2 1 Tf 18.454 -0.001 Td (\t\201\217\205\002\217\007\201\217\206\020\002\007\005 \036\025)Tj /T1_1 1 Tf ( )Tj /T1_0 1 Tf (AUC)Tj /T1_1 1 Tf (:)Tj -7.536 -1.143 Td (LR: 0,75)Tj /Span<>> BDC ( )Tj EMC (\(0,70\2260,80\); LDA: 0,76)Tj /Span<>> BDC ( )Tj EMC (\(0,71\2260,81\); XGBoost- 0,71)Tj /Span<>> BDC ( )Tj EMC (\(0,64\226)Tj 6.312 -1.143 Td (0,76\); CatBoost- 0,75)Tj /Span<>> BDC ( )Tj EMC (\(0,70\2260,81\).)Tj /T1_2 1 Tf 0.973 -1.143 Td (\t\201\217\205\002\217\007\201\217\206\020\002\007\005 \211\027\025)Tj /T1_1 1 Tf ( )Tj /T1_0 1 Tf (AUC:)Tj /T1_1 1 Tf -7.341 -1.143 Td (LR- 0,71)Tj /Span<>> BDC ( )Tj EMC (\(0,61\2260,80\); LDA- 0,71)Tj /Span<>> BDC ( )Tj EMC (\(0,61\2260,80\); XGBoost- 0,69)Tj /Span<>> BDC ( )Tj EMC (\(0,60\226)Tj 6.633 -1.143 Td (0,78\); CatBoost-0,75)Tj /Span<>> BDC ( )Tj EMC (\(0,69\2260,82\))Tj /T1_2 1 Tf 0.597 -1.143 Td (\t\201\217\205\002\217\007\201\217\206\020\002\007\005 \201\005\210\007\ \235\007\206\020)Tj /T1_0 1 Tf 4.947 -1.143 Td (AUC)Tj /T1_1 1 Tf (:)Tj -12.177 -1.143 Td (LR- 0,80)Tj /Span<>> BDC ( )Tj EMC (\(0,65\2260,92\); LDA- 0,83)Tj /Span<>> BDC ( )Tj EMC (\(0,69\2260,93\); XGBoost- 0,81)Tj /Span<>> BDC ( )Tj EMC (\(0,65\226)Tj 6.135 -1.143 Td (0,93\) ; CatBoost- 0,82)Tj /Span<>> BDC ( )Tj EMC (\(0,67\2260,93\) .)Tj 23.025 10.287 Td (5-\022\030\026\021\027\026\016 \022\030\024\f\f-)Tj -1.099 -1.143 Td (\r\026\035\017\007\026\006\017\016)Tj /Span<>> BDC ( )Tj EMC (+)Tj /Span<>> BDC ( )Tj EMC (bootstrap )Tj 2.583 -1.143 Td (validation)Tj 10.64 2.286 Td (12)Tj 6.587 0 Td (1330)Tj -76.193 -11.821 Td (Cardoso et al., )Tj T* (2023 [14] )Tj 8.022 1.143 Td (NB, RF, XGBoost)Tj 8.969 0 Td (1-\035\036\021\027\016\016, 3-\b \035\036\021\027\016\016, )Tj 1.787 -1.143 Td (5-\035\036\021\027\016\016 \210\200)Tj /T1_0 1 Tf 20.067 1.142 Td (5-\f\r\003\b\235\235 \017\026)Tj 1.655 -1.143 Td (AUC:)Tj /T1_1 1 Tf -12.162 -1.143 Td (Na\357ve Bayes)Tj /Span<>> BDC ( )Tj EMC (\227 0,765; Random Forest)Tj /Span<>> BDC ( )Tj EMC (\227 0,844; XGBoost)Tj /Span<>> BDC ( )Tj EMC (\227 0,845.)Tj 28.723 2.287 Td (Train-test split, )Tj /T1_3 1 Tf (ROC)Tj /T1_1 1 Tf ( )Tj 0.595 -1.143 Td (curve evaluation)Tj 11.95 1.143 Td (10)Tj 6.337 0 Td (29670)Tj -75.943 -3.821 Td (Kos et al., 2024 )Tj T* ([15])Tj 8.278 1.143 Td (DT, SVM, K-NN, )Tj 0.955 -1.143 Td (Ensemble )Tj -0.678 -1.143 Td (Classi\251er, NN)Tj 12.153 2.286 Td (\210\200)Tj /T1_0 1 Tf 19.791 -0.001 Td (AUC)Tj /T1_1 1 Tf (:)Tj -11.662 -1.143 Td (SVM)Tj /Span<>> BDC ( )Tj EMC (\227 0,84; DT)Tj /Span<>> BDC ( )Tj EMC (\227 0,81; Ensemble)Tj /Span<>> BDC ( )Tj EMC (\227 0,83; NN)Tj /Span<>> BDC ( )Tj EMC (\227 0,76; KNN)Tj /Span<>> BDC ( )Tj EMC (\227 )Tj 11.679 -1.143 Td (0,76.)Tj 16.716 2.287 Td (10-\022\030\026\021\027\026\016 \022\030\024\f\f-)Tj 1.57 -1.143 Td (\r\026\035\017\007\026\006\017\016)Tj 10.804 1.143 Td (20)Tj 6.837 0 Td (498)Tj -76.443 -3.821 Td (Osman et al., )Tj T* (2022 [16])Tj 9.098 1.143 Td (Light GBM)Tj 9.68 0 Td (5-\035\036\021\027\016\016 \210\200)Tj ET 0.35 w q 1 0 0 1 310.6141 263.4503 cm 0 0 m 1.305 0 l S Q BT /T1_0 1 Tf 5.6 0 0 7 298.3223 272.1502 Tm (AUROC)Tj /T1_1 1 Tf -8.535 -1.143 Td (External Validation- 0,805;)Tj ( )Tj (Sensitivity)Tj /Span<>> BDC ( )Tj EMC (\227 68,14%;)Tj 3.091 -1.143 Td (Positive Predictive Value- 49,88%.)Tj 22.61 2.287 Td (18-\022\030\026\021\027\026\016 \022\030\024\f\f-)Tj 1.57 -1.143 Td (\r\026\035\017\007\026\006\017\016)Tj 10.804 1.143 Td (12)Tj 6.087 0 Td (364316 )Tj -75.693 -3.821 Td (Rodriguez et al., )Tj T* (2023 [17])Tj 8.09 1.143 Td (XGBoost, Lasso, )Tj 0.37 -1.143 Td (Ridge, Elastic )Tj -0.771 -1.143 Td (Net, Superlearner)Tj 11.826 2.286 Td (\217\036\006\017\007\017\r)Tj /T1_0 1 Tf 21.133 -0.001 Td (AUC)Tj /T1_1 1 Tf -8.688 -1.143 Td (XGBoost)Tj /Span<>> BDC ( )Tj EMC (\227 0,87)Tj /Span<>> BDC ( )Tj EMC (\(6 \n\036\f\016\006\036\r\), 0,94)Tj /Span<>> BDC ( )Tj EMC (\(54 \n\036\f\016\006\026\);)Tj 1.598 -1.143 Td (Lasso, Ridge, Elastic Net: AUC 0,58\2260,69)Tj 23.675 2.287 Td (10-\022\030\026\021\027\026\016 \022\030\024\f\f-)Tj 1.57 -1.143 Td (\r\026\035\017\007\026\006\017\016)Tj 10.804 1.143 Td (18)Tj 6.837 0 Td (448)Tj -76.443 -3.821 Td (Zhang W. et al., )Tj 0 -1.143 TD (2023 [42])Tj 7.76 1.143 Td (LR, KNN, SVM, DT, )Tj 0.294 -1.143 Td (RF, balanced RF )Tj 1.963 -1.143 Td (\(BRF\))Tj 7.425 2.286 Td (\204\036\021\026\f\021\026\017\030\024\r\026\027\017\036 )Tj 2.104 -1.143 Td (\f)Tj /Span<>> BDC ( )Tj EMC (\035\036\020\022\017\036)Tj 17.739 1.143 Td (BRF model AUC 0,874)Tj 19.46 0 Td (Internal and external )Tj 2.222 -1.143 Td (validation)Tj 10.64 1.143 Td (18)Tj 6.337 0 Td (48816)Tj -75.943 -3.82 Td (Kudo S.-E. et )Tj 0 -1.143 TD (al., 2021 [19])Tj 10.27 1.143 Td (ANN)Tj 7.171 0 Td (\204\036\021\026\f\021\026\017\030\024\r\026\027\017\036 )Tj 1.118 -1.143 Td (\r)Tj /Span<>> BDC ( )Tj EMC (\035\017\n\235\024\031\035\t)Tj 20.06 1.143 Td (AUC 0,83\2260,84)Tj 18.124 0 Td (Internal and external )Tj 2.222 -1.143 Td (validation)Tj 10.89 1.143 Td (8)Tj 6.337 0 Td (4079)Tj -76.193 -2.677 Td (Wang, Xiaojie et )Tj T* (al., 2022 [20])Tj 8.085 1.143 Td (LASSO, SVM, LR, )Tj -0.338 -1.143 Td (XGB, LightGB, DT, )Tj 1.893 -1.143 Td (RF, MLP)Tj 7.802 2.286 Td (\204\036\021\026\f\021\026\017\030\024\r\026\027\017\036 )Tj 1.118 -1.143 Td (\r)Tj /Span<>> BDC ( )Tj EMC (\035\017\n\235\024\031\035\t)Tj 20.796 1.143 Td (MLP model)Tj -9.043 -1.143 Td (AUC)Tj /Span<>> BDC ( )Tj EMC (\227 0,873, Sensitivity)Tj /Span<>> BDC ( )Tj EMC (\227 81,0%, Speci\251city)Tj /Span<>> BDC ( )Tj EMC (\227 82,5%)Tj 27.053 1.143 Td (5- \022\030\026\021\027\026\016 \022\030\024\f\f-)Tj 1.436 -1.143 Td (\r\026\035\017\007\026\006\017\016)Tj 10.804 1.143 Td (10)Tj 6.587 0 Td (2891)Tj -76.193 -3.82 Td (Chi, Shengqiang )Tj T* (et al., 2019 )Tj T* ([18])Tj 7.823 2.286 Td (Semi-Supervised )Tj 0.331 -1.143 Td (LR, LR, SVM, RF, )Tj 1.616 -1.143 Td (NN, NB)Tj 10.938 2.286 Td (\210\200)Tj 17.262 0 Td (AUC 0,73)Tj /Span<>> BDC ( )Tj EMC (\(LR, NN\))Tj 19.395 0 Td (5- \022\030\026\021\027\026\016 \022\030\024\f\f-)Tj 1.436 -1.143 Td (\r\026\035\017\007\026\006\017\016)Tj 11.054 1.143 Td (6)Tj 5.837 0 Td (115217)Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\007\003\032)50(\n\n\217\n)-21(\035\030\002)]TJ 53.418 0 Td [(MET)30(A)-41(-)-41.9(ANAL)30(Y)30(SIS)]TJ -53.418 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 2)69(4, \023\0224, 202)23(5)]TJ 43.013 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 2)69(4, \023\0224, 202)23(5)]TJ /T1_5 1 Tf 25 0 0 25 20.7527 56.0378 Tm (130)Tj ET endstream endobj 1513 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\030\b\017\200\b\b)-9.9(\026\r\016\215\215\220\207 \021\215\026)11.1(\016\t\t\016\017)-10(\026 \211)-20.9(\t\004 \222\201\025\202\215\025)21(\213\021\201\025\r\001\215\021\004 )]TJ 0 -1 TD [(\025\026)11(\211\001\t\016\215\215\220 \201\016\213)21(\200\t\214)21(\026)11(\001\026)11(\025\r \t\016\f\016\215\021\004 \235\025\t\214\215\220 \017)10(\025\t\025\201\016\017)-9.9(\026)11(\001\t\214\215\220\024 )]TJ T* [(\201\001\017)10(\025\024 \(\b\021\b)-10(\026)11(\016\024\001\026\021\f\016\b\017\021\207 \025\235\213\025\201 \021\022\024\ \016\026)11(\001\001\215\001\t\021\213\))]TJ 34.456 2 Td [(Ar)-20(tif)-21(icial intelligence for pr)31(edicting long-term outcomes in patients )]TJ 1.361 -1 Td [(with color)31(ectal cancer \(a\022s)10(y)10(stematic r)31(e)11(vie)11(w and meta-analy)10(sis\))]TJ /T1_1 1 Tf 9 0 0 9 42.5197 730.483 Tm (\020\004\206\f\t\204\004 2.)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf ( \t\034\b\033\034\025\020\037\030 \002\037\033\037\021\035\016\033\022\024\ \035\022\021\037 \036\021\027\026\005\016\020\020\032\002 \022\024\024\027\ \016\b\034\036\037\020\022\004)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf -0.027 Tc 0.027 Tw 0 -1.2 TD [(T)0.5(a)-35.3(b)-40.7(l)-38.7(e)-27( 2)-34.3(.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf 0 Tc 0 Tw 3.334 0 Td [( D)-10.3(e)-8.6(t)-2(a)-6.3(i)3(le)-12.9(d c)-2.5(ha)-4.2(r)3.3(a)-9.1(c)-32.4(t)-1.6(e)-6(r)-39(i)6.6(s)-14.8(t)-29.1(i)-1.8(c)-26.7(s o)4.1(f)]TJ /Span<>> BDC ( )Tj EMC [(t)-10.6(h)-2.4(e i)3.9(n)-2.9(c)-1.1(lu)-5.9(d)-5.3(e)-12.9(d s)-14.8(t)-1.1(u)-5.9(d)-2.9(i)-1.4(e)-22(s)]TJ ET 0 0 0 1 K 0.5 w /GS2 gs q 1 0 0 1 42.5197 715.181 cm 0 0 m 42.77 0 l S Q q 1 0 0 1 42.7697 688.6868 cm 0 0 m 0 26.244 l S Q q 1 0 0 1 85.2894 715.181 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 85.2894 688.6868 cm 0 0 m 0 26.244 l S Q q 1 0 0 1 130.6437 715.181 cm 0 0 m 68.031 0 l S Q q 1 0 0 1 130.6437 688.6868 cm 0 0 m 0 26.244 l S Q q 1 0 0 1 198.6752 715.181 cm 0 0 m 158.74 0 l S Q q 1 0 0 1 198.6752 688.6868 cm 0 0 m 0 26.244 l S Q q 1 0 0 1 357.4153 715.181 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 357.4153 688.6868 cm 0 0 m 0 26.244 l S Q q 1 0 0 1 416.9429 715.181 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 416.9429 688.6868 cm 0 0 m 0 26.244 l S Q q 1 0 0 1 459.4626 715.181 cm 0 0 m 37.1 0 l S Q q 1 0 0 1 459.4626 688.6868 cm 0 0 m 0 26.244 l S Q q 1 0 0 1 496.313 688.6868 cm 0 0 m 0 26.244 l S Q q 1 0 0 1 42.5197 688.4368 cm 0 0 m 42.77 0 l S Q q 1 0 0 1 42.7697 613.9425 cm 0 0 m 0 74.244 l S Q q 1 0 0 1 85.2894 688.4368 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 85.2894 613.9425 cm 0 0 m 0 74.244 l S Q q 1 0 0 1 130.6437 688.4368 cm 0 0 m 68.031 0 l S Q q 1 0 0 1 130.6437 613.9425 cm 0 0 m 0 74.244 l S Q q 1 0 0 1 198.6752 688.4368 cm 0 0 m 158.74 0 l S Q q 1 0 0 1 198.6752 613.9425 cm 0 0 m 0 74.244 l S Q q 1 0 0 1 357.4153 688.4368 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 357.4153 613.9425 cm 0 0 m 0 74.244 l S Q q 1 0 0 1 416.9429 688.4368 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 416.9429 613.9425 cm 0 0 m 0 74.244 l S Q q 1 0 0 1 459.4626 688.4368 cm 0 0 m 37.1 0 l S Q q 1 0 0 1 459.4626 613.9425 cm 0 0 m 0 74.244 l S Q q 1 0 0 1 496.313 613.9425 cm 0 0 m 0 74.244 l S Q q 1 0 0 1 42.5197 613.6925 cm 0 0 m 42.77 0 l S Q q 1 0 0 1 42.7697 547.1983 cm 0 0 m 0 66.244 l S Q q 1 0 0 1 85.2894 613.6925 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 85.2894 547.1983 cm 0 0 m 0 66.244 l S Q q 1 0 0 1 130.6437 613.6925 cm 0 0 m 68.031 0 l S Q q 1 0 0 1 130.6437 547.1983 cm 0 0 m 0 66.244 l S Q q 1 0 0 1 198.6752 613.6925 cm 0 0 m 158.74 0 l S Q q 1 0 0 1 198.6752 547.1983 cm 0 0 m 0 66.244 l S Q q 1 0 0 1 357.4153 613.6925 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 357.4153 547.1983 cm 0 0 m 0 66.244 l S Q q 1 0 0 1 416.9429 613.6925 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 416.9429 547.1983 cm 0 0 m 0 66.244 l S Q q 1 0 0 1 459.4626 613.6925 cm 0 0 m 37.1 0 l S Q q 1 0 0 1 459.4626 547.1983 cm 0 0 m 0 66.244 l S Q q 1 0 0 1 496.313 547.1983 cm 0 0 m 0 66.244 l S Q q 1 0 0 1 42.5197 546.9483 cm 0 0 m 42.77 0 l S Q q 1 0 0 1 42.7697 472.454 cm 0 0 m 0 74.244 l S Q q 1 0 0 1 85.2894 546.9483 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 85.2894 472.454 cm 0 0 m 0 74.244 l S Q q 1 0 0 1 130.6437 546.9483 cm 0 0 m 68.031 0 l S Q q 1 0 0 1 130.6437 472.454 cm 0 0 m 0 74.244 l S Q q 1 0 0 1 198.6752 546.9483 cm 0 0 m 158.74 0 l S Q q 1 0 0 1 198.6752 472.454 cm 0 0 m 0 74.244 l S Q q 1 0 0 1 357.4153 546.9483 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 357.4153 472.454 cm 0 0 m 0 74.244 l S Q q 1 0 0 1 416.9429 546.9483 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 416.9429 472.454 cm 0 0 m 0 74.244 l S Q q 1 0 0 1 459.4626 546.9483 cm 0 0 m 37.1 0 l S Q q 1 0 0 1 459.4626 472.454 cm 0 0 m 0 74.244 l S Q q 1 0 0 1 496.313 472.454 cm 0 0 m 0 74.244 l S Q q 1 0 0 1 42.5197 472.204 cm 0 0 m 42.77 0 l S Q q 1 0 0 1 42.7697 397.7098 cm 0 0 m 0 74.244 l S Q q 1 0 0 1 85.2894 472.204 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 85.2894 397.7098 cm 0 0 m 0 74.244 l S Q q 1 0 0 1 130.6437 472.204 cm 0 0 m 68.031 0 l S Q q 1 0 0 1 130.6437 397.7098 cm 0 0 m 0 74.244 l S Q q 1 0 0 1 198.6752 472.204 cm 0 0 m 158.74 0 l S Q q 1 0 0 1 198.6752 397.7098 cm 0 0 m 0 74.244 l S Q q 1 0 0 1 357.4153 472.204 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 357.4153 397.7098 cm 0 0 m 0 74.244 l S Q q 1 0 0 1 416.9429 472.204 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 416.9429 397.7098 cm 0 0 m 0 74.244 l S Q q 1 0 0 1 459.4626 472.204 cm 0 0 m 37.1 0 l S Q q 1 0 0 1 459.4626 397.7098 cm 0 0 m 0 74.244 l S Q q 1 0 0 1 496.313 397.7098 cm 0 0 m 0 74.244 l S Q q 1 0 0 1 42.5197 397.4598 cm 0 0 m 42.77 0 l S Q q 1 0 0 1 42.7697 330.9656 cm 0 0 m 0 66.244 l S Q q 1 0 0 1 85.2894 397.4598 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 85.2894 330.9656 cm 0 0 m 0 66.244 l S Q q 1 0 0 1 130.6437 397.4598 cm 0 0 m 68.031 0 l S Q q 1 0 0 1 130.6437 330.9656 cm 0 0 m 0 66.244 l S Q q 1 0 0 1 198.6752 397.4598 cm 0 0 m 158.74 0 l S Q q 1 0 0 1 198.6752 330.9656 cm 0 0 m 0 66.244 l S Q q 1 0 0 1 357.4153 397.4598 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 357.4153 330.9656 cm 0 0 m 0 66.244 l S Q q 1 0 0 1 416.9429 397.4598 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 416.9429 330.9656 cm 0 0 m 0 66.244 l S Q q 1 0 0 1 459.4626 397.4598 cm 0 0 m 37.1 0 l S Q q 1 0 0 1 459.4626 330.9656 cm 0 0 m 0 66.244 l S Q q 1 0 0 1 496.313 330.9656 cm 0 0 m 0 66.244 l S Q q 1 0 0 1 42.5197 330.7156 cm 0 0 m 42.77 0 l S Q q 1 0 0 1 42.7697 176.2283 cm 0 0 m 0 154.237 l S Q q 1 0 0 1 85.2894 330.7156 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 85.2894 176.2283 cm 0 0 m 0 154.237 l S Q q 1 0 0 1 130.6437 330.7156 cm 0 0 m 68.031 0 l S Q q 1 0 0 1 130.6437 176.2283 cm 0 0 m 0 154.237 l S Q q 1 0 0 1 198.6752 330.7156 cm 0 0 m 158.74 0 l S Q q 1 0 0 1 198.6752 176.2283 cm 0 0 m 0 154.237 l S Q q 1 0 0 1 357.4153 330.7156 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 357.4153 176.2283 cm 0 0 m 0 154.237 l S Q q 1 0 0 1 416.9429 330.7156 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 416.9429 176.2283 cm 0 0 m 0 154.237 l S Q q 1 0 0 1 459.4626 330.7156 cm 0 0 m 37.1 0 l S Q q 1 0 0 1 459.4626 176.2283 cm 0 0 m 0 154.237 l S Q q 1 0 0 1 496.313 176.2283 cm 0 0 m 0 154.237 l S Q q 1 0 0 1 42.5197 175.9783 cm 0 0 m 42.77 0 l S Q q 1 0 0 1 42.7697 93.4841 cm 0 0 m 0 82.244 l S Q q 1 0 0 1 85.2894 175.9783 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 85.2894 93.4841 cm 0 0 m 0 82.244 l S Q q 1 0 0 1 130.6437 175.9783 cm 0 0 m 68.031 0 l S Q q 1 0 0 1 130.6437 93.4841 cm 0 0 m 0 82.244 l S Q q 1 0 0 1 198.6752 175.9783 cm 0 0 m 158.74 0 l S Q q 1 0 0 1 198.6752 93.4841 cm 0 0 m 0 82.244 l S Q q 1 0 0 1 357.4153 175.9783 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 357.4153 93.4841 cm 0 0 m 0 82.244 l S Q q 1 0 0 1 416.9429 175.9783 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 416.9429 93.4841 cm 0 0 m 0 82.244 l S Q q 1 0 0 1 459.4626 175.9783 cm 0 0 m 37.1 0 l S Q q 1 0 0 1 459.4626 93.4841 cm 0 0 m 0 82.244 l S Q q 1 0 0 1 496.313 93.4841 cm 0 0 m 0 82.244 l S Q q 1 0 0 1 42.5197 93.2341 cm 0 0 m 42.77 0 l S Q q 1 0 0 1 85.2894 93.2341 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 130.6437 93.2341 cm 0 0 m 68.031 0 l S Q q 1 0 0 1 198.6752 93.2341 cm 0 0 m 158.74 0 l S Q q 1 0 0 1 357.4153 93.2341 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 416.9429 93.2341 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 459.4626 93.2341 cm 0 0 m 37.1 0 l S Q BT /GS1 gs /T1_1 1 Tf 5.6 0 0 7 51.2869 699.2714 Tm (\032\003\002\006, \n\002\240)Tj 8.046 0 Td (\032\f\n\002\006\t\003\214)Tj 6.778 0.571 Td (\200\006\002\n\b\002\213\t\006\210\r\214\013\005 \220\f\t\b\t)Tj 5.6 0 0 7 192.9475 703.2714 Tm (-)Tj 5.6 0 0 7 148.4477 695.2714 Tm (\201\r\217\220\t\005 \t\217\216\002\240)Tj 20.633 0.571 Td (\022\r\213\210\f\001\003\004\003\013)Tj 18.177 0 Td (\215\r\003\002\240 \004\f\t\240\004\204\t\t)Tj 10.554 1.143 Td (\030\t\217\f\002 \004\b\004)Tj 5.6 0 0 7 449.4446 707.2714 Tm (-)Tj 5.6 0 0 7 423.0941 699.2714 Tm (\f\t\213\t\006\210\r\214\013\216 )Tj 0.134 -1.143 Td (\212\004\006\004\214\r\003\006\002)Tj 7.129 1.714 Td (\021\002\f\t\201\r\217\003\002 )Tj 0.229 -1.143 Td (\212\004\204\t\r\b\003\002)Tj /T1_3 1 Tf -74.901 -2.105 Td (Youngbae Jeon, )Tj 0 -1.143 TD (et al. [1] )Tj 7.949 1.143 Td (SVM, RF, EGB, LR)Tj 11.565 0 Td (\217\036\006\017\007\017\r)Tj /T1_1 1 Tf 20.985 -0.001 Td (AUC:)Tj /T1_3 1 Tf -12.504 -1.143 Td (SVM)Tj /Span<>> BDC ( )Tj EMC (\227 0,79)Tj /Span<>> BDC ( )Tj EMC (\(95% \212\236: 0,76\2260,82\); RF)Tj /Span<>> BDC ( )Tj EMC (\227 0,84)Tj /Span<>> BDC ( )Tj EMC (\(95% \212\236: 0,81\2260,87\); )Tj 5.815 -1.143 Td (XGBoost)Tj /Span<>> BDC ( )Tj EMC (\227 0,85)Tj /Span<>> BDC ( )Tj EMC (\(95% \212\236: 0,82\2260,88\).)Tj /T1_1 1 Tf 5.672 -1.143 Td (Accuracy:)Tj /T1_3 1 Tf -9.542 -1.143 Td (SVM)Tj /Span<>> BDC ( )Tj EMC (\227 76% \(95% \212\236: 70-82\); RF)Tj /Span<>> BDC ( )Tj EMC (\227 82%; XGBoost -83%.)Tj /T1_1 1 Tf 9.153 -1.143 Td (Sensitivity:)Tj /T1_3 1 Tf -9.601 -1.143 Td (SVM)Tj /Span<>> BDC ( )Tj EMC (\227 70% \(95% \212\236: 65-75\); RF)Tj /Span<>> BDC ( )Tj EMC (\227 78%; XGBoost)Tj /Span<>> BDC ( )Tj EMC (\227 79%; )Tj /T1_1 1 Tf 9.634 -1.143 Td (Speci\241city:)Tj /T1_3 1 Tf -9.634 -1.143 Td (SVM)Tj /Span<>> BDC ( )Tj EMC (\227 80% \(95% \212\236: 75-85\); RF)Tj /Span<>> BDC ( )Tj EMC (\227 86%; XGBoost)Tj /Span<>> BDC ( )Tj EMC (\227 88%;)Tj 29.337 9.144 Td (Tomek link)Tj 10.778 0 Td (16)Tj 6.837 0 Td (961)Tj -76.443 -10.678 Td (Mo Tang, et)Tj /Span<>> BDC ( )Tj EMC (al. )Tj T* ([2])Tj 7.949 1.143 Td (LR, RF, EGB, SVM)Tj 11.565 0 Td (\217\036\006\017\007\017\r)Tj /T1_1 1 Tf 20.985 -0.001 Td (AUC:)Tj /T1_3 1 Tf -11.346 -1.143 Td (LR)Tj /Span<>> BDC ( )Tj EMC (\227 0,73)Tj /Span<>> BDC ( )Tj EMC (\(95% \212\236: 0,70\2260,76\); RF)Tj /Span<>> BDC ( )Tj EMC (\227 0,74; XGBoost)Tj /Span<>> BDC ( )Tj EMC (\227 0,79.)Tj /T1_1 1 Tf 10.329 -1.143 Td (Accuracy:)Tj /T1_3 1 Tf -9.653 -1.143 Td (LR)Tj /Span<>> BDC ( )Tj EMC (\227 78% \(95% \212\236: 74-82\); RF)Tj /Span<>> BDC ( )Tj EMC (\227 79%; XGBoost)Tj /Span<>> BDC ( )Tj EMC (\227 80%.)Tj /T1_1 1 Tf 9.264 -1.143 Td (Sensitivity:)Tj /T1_3 1 Tf -9.264 -1.143 Td (LR)Tj /Span<>> BDC ( )Tj EMC (\227 75% \(95% \212\236: 71-79\); RF)Tj /Span<>> BDC ( )Tj EMC (\227 76%; XGBoost)Tj /Span<>> BDC ( )Tj EMC (\227 78%.)Tj /T1_1 1 Tf 9.297 -1.143 Td (Speci\241city:)Tj /T1_3 1 Tf -5.322 -1.143 Td (LR)Tj /Span<>> BDC ( )Tj EMC (\227 80%; RF)Tj /Span<>> BDC ( )Tj EMC (\227 81%; XGBoost -83%.)Tj 23.721 8.001 Td (Set Aside Method)Tj 12.082 0 Td (20)Tj 6.837 0 Td (558)Tj -76.443 -9.535 Td (Wen-Chien Ting, )Tj 0 -1.143 TD (et al. [3])Tj 8.404 1.143 Td (SVM, Reduced )Tj 0.071 -1.143 Td (Error Pruning )Tj 1.806 -1.143 Td (Tree)Tj 9.233 2.286 Td (\217\036\006\017\007\017\r)Tj /T1_1 1 Tf 20.985 -0.001 Td (AUC:)Tj /T1_3 1 Tf -12.049 -1.143 Td (SVM)Tj /Span<>> BDC ( )Tj EMC (\227 0,87)Tj /Span<>> BDC ( )Tj EMC (\(95% \212\236: 0,83\2260,91\); Reduced Error Pruning Tree)Tj /Span<>> BDC ( )Tj EMC (\227 )Tj 12.066 -1.143 Td (0,62.)Tj /T1_1 1 Tf -1.034 -1.143 Td (Accuracy:)Tj /T1_3 1 Tf -11.426 -1.143 Td (SVM)Tj /Span<>> BDC ( )Tj EMC (\227 83% \(95% \212\236: 79-87\); Reduced Error Pruning Tree)Tj /Span<>> BDC ( )Tj EMC (\227 78%.)Tj /T1_1 1 Tf 11.037 -1.143 Td (Sensitivity:)Tj /T1_3 1 Tf -7.503 -1.143 Td (SVM)Tj /Span<>> BDC ( )Tj EMC (\227 79%; Reduced Error Pruning Tree)Tj /Span<>> BDC ( )Tj EMC (\227 72%.)Tj /T1_1 1 Tf 7.536 -1.143 Td (Speci\241city:)Tj /T1_3 1 Tf -7.536 -1.143 Td (SVM)Tj /Span<>> BDC ( )Tj EMC (\227 86%; Reduced Error Pruning Tree)Tj /Span<>> BDC ( )Tj EMC (\227 80%.)Tj 25.642 9.144 Td (10-\022\030\026\021\027\026\016 \022\030\024\f\f-)Tj 1.57 -1.143 Td (\r\026\035\017\007\026\006\017\016)Tj 11.054 1.143 Td (7)Tj 6.337 0 Td (4299)Tj -76.193 -10.678 Td (Achilonu OJ, )Tj 0 -1.143 TD (et)Tj /Span<>> BDC ( )Tj EMC (al. [4])Tj 7.632 1.143 Td (na\357ve Bayes \(NB\), )Tj 2.585 -1.143 Td (C5,0,)Tj -2.259 -1.143 Td (LR, RF SVM, ANN)Tj 11.556 2.286 Td (\217\036\006\017\007\017\r )Tj /T1_1 1 Tf 20.985 -0.001 Td (AUC:)Tj /T1_3 1 Tf -10.562 -1.143 Td (LR)Tj /Span<>> BDC ( )Tj EMC (\227 0,93; NB)Tj /Span<>> BDC ( )Tj EMC (\227 0,92; RF)Tj /Span<>> BDC ( )Tj EMC (\227 0,94; ANN)Tj /Span<>> BDC ( )Tj EMC (\227 0,95)Tj /Span<>> BDC ( )Tj EMC (\(95% \212\236: )Tj 9.274 -1.143 Td (0,92\2260,98\).)Tj /T1_1 1 Tf 0.272 -1.143 Td (Accuracy:)Tj /T1_3 1 Tf -5.034 -1.143 Td (LR)Tj /Span<>> BDC ( )Tj EMC (\227 87%; NB)Tj /Span<>> BDC ( )Tj EMC (\227 86%; RF)Tj /Span<>> BDC ( )Tj EMC (\227 88%.)Tj /T1_1 1 Tf 4.645 -1.143 Td (Sensitivity:)Tj /T1_3 1 Tf -4.645 -1.143 Td (LR)Tj /Span<>> BDC ( )Tj EMC (\227 85%; NB)Tj /Span<>> BDC ( )Tj EMC (\227 83%; RF)Tj /Span<>> BDC ( )Tj EMC (\227 86%.)Tj /T1_1 1 Tf 4.678 -1.143 Td (Speci\241city:)Tj /T1_3 1 Tf -4.678 -1.143 Td (LR)Tj /Span<>> BDC ( )Tj EMC (\227 89%; NB)Tj /Span<>> BDC ( )Tj EMC (\227 87%; RF)Tj /Span<>> BDC ( )Tj EMC (\227 90%.)Tj 22.784 9.144 Td (10-\022\030\026\021\027\026\016 \022\030\024\f\f-)Tj 1.57 -1.143 Td (\r\026\035\017\007\026\006\017\016)Tj 10.804 1.143 Td (13)Tj 6.837 0 Td (716)Tj -76.443 -10.678 Td (Chen PC, et)Tj /Span<>> BDC ( )Tj EMC (al. )Tj T* ([5])Tj 8.224 1.143 Td (LR, RF, DT, SVM)Tj 11.291 0 Td (\217\036\006\017\007\017\r)Tj /T1_1 1 Tf 20.985 -0.001 Td (AUC:)Tj /T1_3 1 Tf -6.377 -1.143 Td (LR)Tj /Span<>> BDC ( )Tj EMC (\227 0,87; RF)Tj /Span<>> BDC ( )Tj EMC (\227 0,84; CART)Tj /Span<>> BDC ( )Tj EMC (\227 0,83.)Tj /T1_1 1 Tf 5.36 -1.143 Td (Accuracy:)Tj /T1_3 1 Tf -5.471 -1.143 Td (LR)Tj /Span<>> BDC ( )Tj EMC (\227 84%; RF)Tj /Span<>> BDC ( )Tj EMC (\227 83%; CART)Tj /Span<>> BDC ( )Tj EMC (\227 82%.)Tj /T1_1 1 Tf 5.082 -1.143 Td (Sensitivity:)Tj /T1_3 1 Tf -5.082 -1.143 Td (LR)Tj /Span<>> BDC ( )Tj EMC (\227 81%; RF)Tj /Span<>> BDC ( )Tj EMC (\227 80%; CART)Tj /Span<>> BDC ( )Tj EMC (\227 79%.)Tj /T1_1 1 Tf 5.115 -1.143 Td (Speci\241city:)Tj /T1_3 1 Tf -5.115 -1.143 Td (LR)Tj /Span<>> BDC ( )Tj EMC (\227 86%; RF)Tj /Span<>> BDC ( )Tj EMC (\227 85%; CART)Tj /Span<>> BDC ( )Tj EMC (\227 84%.)Tj 23.471 8.001 Td (5-\022\030\026\021\027\026\016 \022\030\024\f\f-)Tj 1.32 -1.143 Td (\r\026\035\017\007\026\006\017\016)Tj 10.804 1.143 Td (13)Tj 6.587 0 Td (1073)Tj -76.193 -9.535 Td (Alinia S, Zhou C, )Tj T* (et al. [6])Tj 8.182 1.143 Td (DT, RF, RSF, GB, )Tj 0.082 -1.143 Td (mboost, DLNN, )Tj -0.127 -1.143 Td (Cox Regression)Tj 8.572 2.286 Td (\217\036\006\017\007\017\r \017)Tj /Span<>> BDC ( )Tj EMC (\f\n\036\030\021\027\024\f\021\034)Tj /T1_4 1 Tf 19.257 0 Td (\t\201\217\205\002\217\007\201\217\206\020\002\007\005 \017\207\005\201\ \b\007)Tj /T1_1 1 Tf 3.516 -1.143 Td (Accuracy)Tj /T1_3 1 Tf (:)Tj -11.07 -1.143 Td (RF)Tj /Span<>> BDC ( )Tj EMC (\227 96% \(0,81\2260,99\); GB)Tj /Span<>> BDC ( )Tj EMC (\227 71,4% \(0,57\2260,83\); Mboost)Tj /Span<>> BDC ( )Tj EMC (\227 89% )Tj 10.606 -1.143 Td (\(0,78\2260,96\);)Tj /T1_1 1 Tf 0.075 -1.143 Td (Sensitivity:)Tj /T1_3 1 Tf -9.902 -1.143 Td (DT)Tj /Span<>> BDC ( )Tj EMC (\227 78,3% \(0,56\2260,92\); RF)Tj /Span<>> BDC ( )Tj EMC (\227 100% \(0,85\2261\); RSF)Tj /Span<>> BDC ( )Tj EMC (\227 77,5% )Tj -0.338 -1.143 Td (\(0,66\2260,86\); GB)Tj /Span<>> BDC ( )Tj EMC (\227 75,9% \(0,56\2260,89\); Mboost)Tj /Span<>> BDC ( )Tj EMC (\227 96,9% \(0,83\226)Tj 11.471 -1.143 Td (0,99\);)Tj /T1_4 1 Tf -4.771 -1.143 Td (\t\201\217\205\002\217\007\201\217\206\020\002\007\005 \201\005\210\007\ \235\007\206\020)Tj /T1_1 1 Tf 3.93 -1.143 Td (Accuracy:)Tj /T1_3 1 Tf -10.324 -1.143 Td (RF)Tj /Span<>> BDC ( )Tj EMC (\227 67,8% \(0,47\2260,84\); RSF)Tj /Span<>> BDC ( )Tj EMC (\227 74% \(0,66\2260,81\); GB)Tj /Span<>> BDC ( )Tj EMC (\227 96% )Tj 4.045 -1.143 Td (\(0,87\2260,99\); mboost)Tj /Span<>> BDC ( )Tj EMC (\227 76% \(0,63\2260,87\);)Tj /T1_1 1 Tf 5.89 -1.143 Td (Sensitivity:)Tj /T1_3 1 Tf -9.843 -1.143 Td (RF)Tj /Span<>> BDC ( )Tj EMC (\227 100% \(0,82\2261\); RSF)Tj /Span<>> BDC ( )Tj EMC (\227 77,8% \(0,66\2260,86\); GB)Tj /Span<>> BDC ( )Tj EMC (\227 100% )Tj 10.36 -1.143 Td (\(0,87\2261\);)Tj -4.118 -1.143 Td (Mboost)Tj /Span<>> BDC ( )Tj EMC (\227 96,8% \(0,83\2260,99\);)Tj /T1_1 1 Tf 3.633 -1.143 Td (Speci\241city:)Tj /T1_3 1 Tf -10.547 -1.143 Td (RF)Tj /Span<>> BDC ( )Tj EMC (\227 0% \(0\2260,28\); RSF)Tj /Span<>> BDC ( )Tj EMC (\227 71% \(0,58\2260,81\); GB)Tj /Span<>> BDC ( )Tj EMC (\227 92,9% \(0,76\226)Tj 0.347 -1.143 Td (0,99\); Mboost)Tj /Span<>> BDC ( )Tj EMC (\227 53,8% \(0,33\2260,73\); DLNN)Tj /Span<>> BDC ( )Tj EMC (\227 98% \(0,97\2260,98\))Tj 28.996 20.571 Td (Train-Test Split)Tj 11.934 0 Td (7)Tj 6.587 0 Td (284)Tj -76.443 -22.105 Td (Erkan K., et al., )Tj T* (2024 [7])Tj 8.574 1.143 Td (CatBoost, RF, )Tj -0.72 -1.143 Td (AdaBoost, 16 ML )Tj 0.485 -1.143 Td (models tested)Tj 11.176 2.286 Td (\217\036\006\017\007\017\r)Tj /T1_1 1 Tf 20.985 -0.001 Td (AUC:)Tj /T1_3 1 Tf -8.574 -1.143 Td (CatBoost)Tj /Span<>> BDC ( )Tj EMC (\227 0,92; RF)Tj /Span<>> BDC ( )Tj EMC (\227 0,78; AdaBoost)Tj /Span<>> BDC ( )Tj EMC (\227 0,80.)Tj /T1_1 1 Tf 7.557 -1.143 Td (Accuracy:)Tj /T1_3 1 Tf -7.668 -1.143 Td (CatBoost)Tj /Span<>> BDC ( )Tj EMC (\227 88%; RF)Tj /Span<>> BDC ( )Tj EMC (\227 79%; AdaBoost)Tj /Span<>> BDC ( )Tj EMC (\227 69%.)Tj /T1_1 1 Tf 8.254 -1.143 Td (Recall:)Tj /T1_3 1 Tf -8.254 -1.143 Td (CatBoost)Tj /Span<>> BDC ( )Tj EMC (\227 70%; RF)Tj /Span<>> BDC ( )Tj EMC (\227 67%; AdaBoost)Tj /Span<>> BDC ( )Tj EMC (\227 69%.)Tj /T1_1 1 Tf 7.572 -1.143 Td (Precision:)Tj /T1_3 1 Tf -7.572 -1.143 Td (CatBoost)Tj /Span<>> BDC ( )Tj EMC (\227 90%; RF)Tj /Span<>> BDC ( )Tj EMC (\227 81%; AdaBoost)Tj /Span<>> BDC ( )Tj EMC (\227 83%.)Tj /T1_1 1 Tf 7.727 -1.143 Td (F1-score:)Tj /T1_3 1 Tf -7.727 -1.143 Td (CatBoost)Tj /Span<>> BDC ( )Tj EMC (\227 77%; RF)Tj /Span<>> BDC ( )Tj EMC (\227 74%; AdaBoost)Tj /Span<>> BDC ( )Tj EMC (\227 75%.)Tj 25.301 10.287 Td (10- \022\030\026\021\027\026\016 \022\030\024\f\f-)Tj -0.716 -1.143 Td (\r\026\035\017\007\026\006\017\016)Tj /Span<>> BDC ( )Tj EMC (+)Tj /Span<>> BDC ( )Tj EMC (train-test )Tj 3.705 -1.143 Td (split)Tj 9.752 2.286 Td (9)Tj 6.587 0 Td (396)Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\007\003\032)50(\n\n\217\n)-21(\035\030\002)]TJ 53.418 0 Td [(MET)30(A)-41(-)-41.9(ANAL)30(Y)30(SIS)]TJ /T1_5 1 Tf 25 0 0 25 505.5021 56.0378 Tm (129)Tj ET endstream endobj 1511 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.323 Tw 10 0 0 10 70.8661 724.8299 Tm (\023\036\030\r\t\036 400 \(\024\021\f\024\030\021\017\030\024\r\026\027\027\ \t\b \023\024)Tj /Span<>> BDC ( )Tj EMC (\030\036\035\036\r\026\027\021\027\024\f\021\017\). )Tj 0.103 Tw 0 -1.218 TD [(\200\f\036\020\024 )0.5(\007\035\016 \023\024\007\030\024\002\027\024\020\024 )0.5(\026\027\026\035\017\026 \002\t\035\024 )0.5(\r\022\035\033\004\036\027\024 3526 )]TJ 0 Tw T* (\f\021\026\021\036\005 \(\217\017\f.)Tj /Span<>> BDC ( )Tj EMC (1\).)Tj 0.476 Tw T* (\200 \b\024\007\036 \023\036\030\r\024\027\026\004\026\035\034\027\024\020\ \024 \023\024\017\f\022\026 \002\t\035\024 \r\t\016\r\035\036\027\024 )Tj 0.003 Tw T* (657106 \f\021\026\021\036\005. \236)Tj /Span<>> BDC ( )Tj EMC (\027\017\b 3526 \f\021\026\021\036\005 \002\t\035\017 \023\030\024\026\027\ \026\035\017\017)Tj 0 Tw (-)Tj 0.055 Tw T* (\030\024\r\026\027\t, \026)Tj /Span<>> BDC ( )Tj EMC (3483 \002\t\035\017 \017\f\022\035\033\004\036\027\t \023\024)Tj /Span<>> BDC ( )Tj EMC (\f\035\036\007\031\033\013\017\n \023\030\017)Tj 0 Tw (-)Tj -0.027 Tw 0 -1.218 TD (\004\017\027\026\n: 1214 \f\021\026\021\036\005 \027\036 \002\t\035\017 \ \f\r\016\026\027\t \f)Tj /Span<>> BDC ( )Tj EMC (\017\f\022\031\f\f\021\r\036\027\027\t\n )Tj 0.19 Tw 0 -1.218 TD (\017\027\021\036\035\035\036\022\021\024\n, 348 \f\021\026\021\036\005 \027\ \036 \002\t\035\017 \023\024\f\r\016\013\036\027\t \022\024\035\024)Tj 0 Tw (-)Tj 0.228 Tw T* (\030\036\022\021\026\035\034\027\024\n\031 \030\026\022\031, 455 \002\t\035\ \017 \024\002\024\030\026\n\017 \035\017\021\036\030\026\021\031\030\t,\ )Tj 0.101 Tw T* (\026)Tj /Span<>> BDC ( )Tj EMC (1366 \027\036 \017\n\036\035\017 \024\021\027\024\001\036\027\017\016 \022\ )Tj /Span<>> BDC ( )Tj EMC (\023\030\024\020\027\024\017\030\024\r\026\027\017\033 \030\036)Tj 0 Tw (-)Tj 0.137 Tw T* (\006\017\007\017\r\026. \230\026\022 \032\036 \002\t\035\024 \017\f\022\035\ \033\004\036\027\024 100 \017\f\f\035\036\007\024\r\026\027\017\005, )Tj 0.14 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\022\024\021\024\030\t\b \017\031\004\026\035\017\f\034 \n\024\007\036\035\ \017 \017\f\022\031\f\f\021\r\036\027\027\024\020\024 \017\027\021\036\035\ )Tj 0 Tw (-)Tj 0.22 Tw 0 -1.218 TD (\035\036\022\021\026 \027\026)Tj /Span<>> BDC ( )Tj EMC (\024\f\027\024\r\036 \030\026\007\017\024\035\024\020\017\004\036\f\022\017\ \b, \020\017\f\021\024\035\024\020\017\004\036\f\022\017\b )Tj 0.085 Tw 0 -1.218 TD (\017\024\002\030\026\032\036\027\017\005 \017)Tj /Span<>> BDC ( )Tj EMC (\020\036\027\024\n\027\t\b \007\026\027\027\t\b. \200)Tj /Span<>> BDC ( )Tj EMC (\022\024\027\036\004\027\024\n \017\021\024\020\036 )Tj 0.447 Tw 0 -1.218 TD (43 \f\021\026\021\034\017 \f\024\024\021\r\036\021\f\021\r\024\r\026\035\ \017 \022\030\017\021\036\030\017\016\n \r\022\035\033\004\036\027\017\016\ )Tj 0 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\002\t\035\017 \r\022\035\033\004\036\027\t \r)Tj /Span<>> BDC ( )Tj EMC (\007\026\027\027\t\005 \024\002\024\030.)Tj /T1_1 1 Tf T* (\025\004\001\200\006\005\002\002\240\005 \017\b\020\b\203\007)Tj /T1_0 1 Tf 0.381 Tw T* (\200\f\036 \r\022\035\033\004\036\027\027\t\036 \017\f\f\035\036\007\024\ \r\026\027\017\016 \002\t\035\017 \024\023\031\002\035\017\022\024\r\026\ )Tj 0 Tw (-)Tj 0.293 Tw T* [(\027\t )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 2.652 0 Td [(\030\036\006\036\027\017\030\031\036\n\t\b )0.6(\032\031\030\027\026\035\026\b )0.6(\(43 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 14.823 0 Td [(43, )0.5(100%\). )]TJ 0.121 Tw -17.475 -1.218 Td [(\215\031\002\035\017\022\026\006\017\017 \024\b\r\026\021\t\r\026\033\021\ )0.5(\023\036\030\017\024\007 \f)]TJ /Span<>> BDC ( )Tj EMC (2018 \023\024)Tj /Span<>> BDC ( )Tj EMC (2024)Tj /Span<>> BDC ( )Tj EMC (\020\020.: )Tj 0.194 Tw T* (2/43 \(4,7%\) \002\t\035\017 \024\023\031\002\035\017\022\024\r\026\027\t\ \r)Tj /Span<>> BDC ( )Tj EMC (2018 \020\024\007\031, 2/43 )Tj -0.059 Tw T* (\(4,7%\))Tj /Span<>> BDC ( )Tj EMC (\227 \r)Tj /Span<>> BDC ( )Tj EMC (2019 \020\024\007\031, 2/43 \(4,7%\))Tj /Span<>> BDC ( )Tj EMC (\227 \r)Tj /Span<>> BDC ( )Tj EMC (2020 \020\024\007\031, 3/43 )Tj 0.103 Tw T* (\(7,0%\))Tj /Span<>> BDC ( )Tj EMC (\227 \r)Tj /Span<>> BDC ( )Tj EMC (2021 \020\024\007\031, 9/43 \(20,9%\))Tj /Span<>> BDC ( )Tj EMC (\227 \r)Tj /Span<>> BDC ( )Tj EMC (2022)Tj /Span<>> BDC ( )Tj EMC (\020\024\007\031, )Tj 0.218 Tw T* [(13/43 )0.5(\(30,2%\))]TJ /Span<>> BDC ( )Tj EMC 6.528 0 Td [(\227 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 2.375 0 Td [(2023 )0.5(\020\024\007\031 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 5.679 0 Td [(12/43 )0.5(\(27,9%\))]TJ /Span<>> BDC ( )Tj EMC 6.528 0 Td (\227 )Tj -0.011 Tw -21.11 -1.218 Td (\r)Tj /Span<>> BDC ( )Tj EMC 0.695 0 Td [(2024 )0.5(\020\024\007\031. )0.5(\025\024\035\017\004\036\f\021\r\024 )0.6(\023\026\006\017\036\027\021\024\r )0.6(\r)]TJ /Span<>> BDC ( )Tj EMC 14.789 0 Td [(\220\021\017\b )0.6(\017\f\f\035\036\007\024\r\026)]TJ 0 Tw (-)Tj -15.485 -1.218 Td (\027\017\016\b \r\026\030\034\017\030\024\r\026\035\024\f\034 \024\021 1\ 64 \007\024)Tj /Span<>> BDC ( )Tj EMC (528 060.)Tj -0.027 Tw T* (\200\024 \r\f\036\b 43 \017\f\f\035\036\007\024\r\026\027\017\016\b \017\ \f\023\024\035\034\024\r\026\035\017\f\034 \026\035\020\024\030\017\021\ \n\t )Tj 0.112 Tw T* (\n\026\001\017\027\027\024\020\024 \024\002\031\004\036\027\017\016, \023\ \030\017)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\n \r)Tj /Span<>> BDC ( )Tj EMC (3)Tj /Span<>> BDC ( )Tj EMC (\(7%\) \017\f\f\035\036\007\024\r\026)Tj 0 Tw (-)Tj 0.098 Tw T* (\027\017\016\b \007\024\023\024\035\027\017\021\036\035\034\027\024 \023\ \030\017\n\036\027\016\035\017\f\034 \n\036\021\024\007\t \020\035\031\002\ \024\022\024\020\024 )Tj 0.149 Tw T* [(\024\002\031\004\036\027\017\016. R)-10(and)-16(om F)10(or)-24(est \024\022\026\026\035\f\016 \f\026\n\t\n \004\026\f\021\024 \017\f)]TJ 0 Tw (-)Tj 0.227 Tw T* [(\023\024\035\034\031\036\n\t\n )0.5(\026\035\020\024\030\017\021\n\024\n, \026\007\036\005\f\021\r\024\r\026\ \027\027\t\n )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC (29/43 )Tj 0.118 Tw T* [(\(67%\) \017\f\f\035\036\007\024\r\026\027\017\016\b. \212\026\035\036\036\ \f\035\036\007\031\036\021 Suppor)-22(t V)30(ec)-16(t)17(or )]TJ 0.146 Tw T* [(Ma)-17(chine, )0.6(\023\030\017\n\036\027\016\r\001\017\005\f\016 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 11.793 0 Td [(22/43 )0.5(\(51%\) )0.5(\017\f\f\035\036\007\024\r\026)]TJ 0 Tw (-)Tj 0.098 Tw -11.793 -1.218 Td (\027\017\017, \026\021\036\n \035\024\020\017\f\021\017\004\036\f\022\026\ \016 \030\036\020\030\036\f\f\017\016 \017)Tj /Span<>> BDC ( )Tj EMC [(X)16(GBo)-15.9(ost, \022\026\032)]TJ 0 Tw (-)Tj 0.118 Tw T* (\007\t\005 \017)Tj /Span<>> BDC ( )Tj EMC (\022\024\021\024\030\t\b \r\f\021\030\036\004\026\035\f\016 \r)Tj /Span<>> BDC ( )Tj EMC (16/43 \(37%\) \017\f\f\035\036\007\024)Tj 0 Tw (-)Tj 0.022 Tw T* [(\r\026\027\017\016\b. )0.5(\224\030\036\007\017 \023\030\024\004\017\b )0.5(\n\036\021\024\007\024\r \n\024\032\027\024 )0.5(\024\021\n\036\021\017\021\034 Nai)-15.9(ve )]TJ 0.228 Tw 23.244 -2.436 Td [(Ba)15(yes 7/43 \(16%\), Ar)-22(t)-32(i\251c)-23.9(ial Neur)-32.9(al Ne)-12(t)-32(w)-14(or)-23.9(k)-10(s 11/43 )]TJ 0.129 Tw T* (\(26%\) \017)Tj /Span<>> BDC ( )Tj EMC [(Dec)-23.9(ision T)50(r)-23.9(ee 15/43 \(35%\). \216\026\030\026\022\021\036\030\017\f\021\017\022\017\ )]TJ 0.172 Tw T* (\n\036\021\024\007\024\r \236\236, \023\030\017\n\036\027\016\036\n\t\b \ \r)Tj /Span<>> BDC ( )Tj EMC (\022\026\032\007\024\n \017\f\f\035\036\007\024\r\026\027\017\017, )Tj 0 Tw T* (\023\030\036\007\f\021\026\r\035\036\027\t \r)Tj /Span<>> BDC ( )Tj EMC (\021\026\002\035\017\006\036 2.)Tj 0.035 Tw T* (\200 \021\026\002\035\017\006\036 2 \023\030\036\007\f\021\026\r\035\036\ \027\t \022\035\033\004\036\r\t\036 \b\026\030\026\022\021\036\030\017\f\ \021\017\022\017 )Tj 0.102 Tw T* (\023\030\024\r\036\007\201\027\027\t\b \017\f\f\035\036\007\024\r\026\027\ \017\005, \r\022\035\033\004\026\033\013\017\036 \024\002\013\036\036 \022\ \024)Tj 0 Tw (-)Tj 0.108 Tw T* (\035\017\004\036\f\021\r\024 \023\026\006\017\036\027\021\024\r, \004\017\ \f\035\024 \026\027\026\035\017\017\030\031\036\n\t\b \023\026\030\026\n\ \036\021)Tj 0 Tw (-)Tj -0.037 Tw T* (\030\024\r, \023\030\017\n\036\027\016\036\n\t\036 \026\035\020\024\030\017\ \021\n\t \017)Tj /Span<>> BDC ( )Tj EMC (\017\f\023\024\035\034\031\036\n\t\036 \n\036\021\024\007\t )Tj 0.023 Tw T* (\r\026\035\017\007\026\006\017\017. \232\026\013\036 \r\f\036\020\024 \r\ )Tj /Span<>> BDC ( )Tj EMC (\022\026\004\036\f\021\r\036 \r\b\024\007\027\t\b \023\036\030\036\n\036\ \027)Tj 0 Tw (-)Tj 0.015 Tw T* (\027\t\b \235\017\020\031\030\017\030\024\r\026\035\017: \r\024\030\026\ \f\021, \023\024\035, \035\024\022\026\035\017\026\006\017\016 \024\023\ \031\b\024)Tj 0 Tw (-)Tj 0.114 Tw T* [(\035\017, )0.5(\f\021\026\007\017\016 )0.6(\024\023\031\b\024\035\036\r\024\020\024 )0.5(\023\030\024\006\036\f\f\026 )0.6(\023\024)]TJ /Span<>> BDC ( )Tj EMC 15.667 0 Td (\022\035\026\f\f\017\235\017\022\026\006\017\017 )Tj 0.232 Tw -15.667 -1.218 Td (TNM, \022\024\035\017\004\036\f\021\r\024 \031\007\026\035\201\027\027\t\ \b \017)Tj /Span<>> BDC ( )Tj EMC (\023\024\030\026\032\201\027\027\t\b \035\017\n\235\024)Tj 0 Tw (-)Tj 0.089 Tw T* (\031\035\024\r, \030\026\n\036\030 \024\023\031\b\024\035\017 \017)Tj /Span<>> BDC ( )Tj EMC (\f\021\036\023\036\027\034 \007\017\235\235\036\030\036\027\006\017\030\024\ \r\022\017, )Tj 0.255 Tw T* (\027\026\035\017\004\017\036 \035\017\n\235\024\r\026\f\022\031\035\016\030\ \027\024\005 \017)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\017\027\036\r\030\026\035\034\027\024\005 \017\027)Tj 0 Tw (-)Tj 0.03 Tw T* [(\r\026\017\017, )0.6(\f\021\026\021\031\f )0.5(\022\030\026\201\r )0.5(\030\036\036\022\006\017\017, )0.6(\031\030\024\r\036\027\034 )0.5(\024\027\022\024\n\026\030\022\201\030\024\r )]TJ -0.001 Tw T* (CEA \017)Tj /Span<>> BDC ( )Tj EMC [(C)20(A 19-9, \n\031\021\026\006\017\024\027\027\t\005 \f\021\026\021\031\f, \023\ \024\022\026\026\021\036\035\017 \024\002\013\036)]TJ 0 Tw (-)Tj -0.057 Tw T* (\020\024 \017)Tj /Span<>> BDC ( )Tj EMC (\002\017\024\b\017\n\017\004\036\f\022\024\020\024 \026\027\026\035\017\ \026 \022\030\024\r\017 \023\024\022\026\026\021\036\035\017 \022\030\024\ \r\017 )Tj ET q 70.866 133.439 221.102 150.762 re W n q /GS0 gs 221.1023475 0 0 150.7625209 70.8661351 133.4390247 cm /Im0 Do Q Q BT 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.324 Tw 9 0 0 9 70.8661 122.5701 Tm (\022\t\217\210\b\002\220 1.)Tj 0 0 0 1 k /GS1 gs /T1_3 1 Tf ( \210\027\034\021-\024\002\016\006\037 PRISMA-ScR \(\f\033\016\b\f\034\005\ \035\022\035\016\027\003\020\032\016 )Tj 0.469 Tw 0 -1.2 TD (\220\027\016\006\016\020\035\032 \034\035\005\016\035\020\034\024\035\022\ \b\027\030 \024\022\024\035\016\006\037\035\022\005\016\024\021\022\002\ \034\025\031\034\033\034\036 )Tj 0 Tw T* (\022)Tj /Span<>> BDC ( )Tj EMC (\006\016\035\037\037\020\037\027\022\031\034\036\))Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.038 Tw T* [(F)-16(igure 1)47.1(.)]TJ 0 0 0 1 k /GS1 gs /T1_3 1 Tf [( P)66(RISMA-ScR f)-22(low)11.1(char)-40(t \(p)46(refer)-15.9(red repor)-40(ting elements )]TJ 0 Tw T* [(for systematic revie)10.2(ws and meta-analyses\))]TJ 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.027 Tw 25.827 72.346 Td (\020\004\206\f\t\204\004 1.)Tj 0 0 0 1 k /GS1 gs /T1_3 1 Tf ( \212\037\033\037\021\035\016\033\022\024\035\022\021\022 \022\024\f\034\ \027\003\031\023\016\006\032\002 \006\016\035\034\b\034\036 \022\024\021\ \023\024)Tj 0 Tw (-)Tj T* (\024\035\036\016\020\020\034\013\034 \022\020\035\016\027\027\016\021\035\ \037)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf -0.027 Tc 0.107 Tw 0 -1.2 TD [(T)0.5(a)-35.3(b)-40.7(l)-38.7(e)-27( )0.5(1)-24.5(.)]TJ 0 0 0 1 k /GS1 gs /T1_3 1 Tf 0 Tc 0.08 Tw 3.403 0 Td [( )0.5(C)-1.1(ha)-4.1(r)3.3(a)-9.2(c)-32.4(t)-1.6(e)-6(r)-39(i)6.6(s)-14.8(t)-29.1(i)-1.7(c)-26.7(s )0.5(o)4(f)]TJ /Span<>> BDC ( )Tj EMC 7.559 0 Td [(t)-10.6(h)-2.4(e )0.6(a)-4.2(r)-41.9(t)-29.1(i)6.4(\244)-1.2(c)-30.1(i)1.5(a)-4.4(l )0.5(i)3.9(n)-0.6(t)-1.6(e)-6.1(l)-3.8(li)1.3(g)-6.8(e)-7(n)-2.9(c)2.8(e )0.6(m)-5.3(e)-8.6(t)-10.6(h)-2.4(o)-12(d)-5.8(s )]TJ 0 Tw -10.962 -1.2 Td [(u)-4.4(s)0.5(e)-12.9(d)]TJ ET 0 0 0 1 K 0.5 w /GS2 gs q 1 0 0 1 303.3071 693.581 cm 0 0 m 79.62 0 l S Q q 1 0 0 1 303.5571 672.7618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 382.9272 693.581 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 382.9272 672.7618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 439.6201 693.581 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 439.6201 672.7618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 524.6594 672.7618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 303.3071 672.5118 cm 0 0 m 79.62 0 l S Q q 1 0 0 1 303.5571 661.3005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 382.9272 672.5118 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 439.6201 672.5118 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 524.6594 661.3005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 303.3071 661.0505 cm 0 0 m 79.62 0 l S Q q 1 0 0 1 303.5571 640.2392 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 382.9272 661.0505 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 382.9272 640.2392 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 439.6201 661.0505 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 439.6201 640.2392 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 524.6594 640.2392 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 303.3071 639.9892 cm 0 0 m 79.62 0 l S Q q 1 0 0 1 303.5571 619.1779 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 382.9272 639.9892 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 382.9272 619.1779 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 439.6201 639.9892 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 439.6201 619.1779 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 524.6594 619.1779 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 303.3071 618.9279 cm 0 0 m 79.62 0 l S Q q 1 0 0 1 303.5571 607.7167 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 382.9272 618.9279 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 439.6201 618.9279 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 524.6594 607.7167 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 303.3071 607.4667 cm 0 0 m 79.62 0 l S Q q 1 0 0 1 303.5571 577.0554 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 382.9272 607.4667 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 382.9272 577.0554 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 439.6201 607.4667 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 439.6201 577.0554 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 524.6594 577.0554 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 303.3071 576.8054 cm 0 0 m 79.62 0 l S Q q 1 0 0 1 303.5571 546.394 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 382.9272 576.8054 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 382.9272 546.394 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 439.6201 576.8054 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 439.6201 546.394 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 524.6594 546.394 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 303.3071 546.144 cm 0 0 m 79.62 0 l S Q q 1 0 0 1 303.5571 525.3328 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 382.9272 546.144 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 382.9272 525.3328 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 439.6201 546.144 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 439.6201 525.3328 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 524.6594 525.3328 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 303.3071 525.0828 cm 0 0 m 79.62 0 l S Q q 1 0 0 1 303.5571 504.2715 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 382.9272 525.0828 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 382.9272 504.2715 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 439.6201 525.0828 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 439.6201 504.2715 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 524.6594 504.2715 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 303.3071 504.0215 cm 0 0 m 79.62 0 l S Q q 1 0 0 1 303.5571 492.8102 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 382.9272 504.0215 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 382.9272 492.8102 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 439.6201 504.0215 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 439.6201 492.8102 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 492.8102 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 303.3071 492.5602 cm 0 0 m 79.62 0 l S Q q 1 0 0 1 303.5571 471.749 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 382.9272 492.5602 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 382.9272 471.749 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 439.6201 492.5602 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 439.6201 471.749 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 524.6594 471.749 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 303.3071 471.499 cm 0 0 m 79.62 0 l S Q q 1 0 0 1 303.5571 450.6877 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 382.9272 471.499 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 382.9272 450.6877 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 439.6201 471.499 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 439.6201 450.6877 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 524.6594 450.6877 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 303.3071 450.4377 cm 0 0 m 79.62 0 l S Q q 1 0 0 1 303.5571 439.2264 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 382.9272 450.4377 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 382.9272 439.2264 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 439.6201 450.4377 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 439.6201 439.2264 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 439.2264 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 303.3071 438.9764 cm 0 0 m 79.62 0 l S Q q 1 0 0 1 303.5571 408.5651 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 382.9272 438.9764 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 382.9272 408.5651 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 439.6201 438.9764 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 439.6201 408.5651 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 524.6594 408.5651 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 303.3071 408.3151 cm 0 0 m 79.62 0 l S Q q 1 0 0 1 303.5571 387.5038 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 382.9272 408.3151 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 382.9272 387.5038 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 439.6201 408.3151 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 439.6201 387.5038 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 524.6594 387.5038 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 303.3071 387.2538 cm 0 0 m 79.62 0 l S Q q 1 0 0 1 303.5571 366.4425 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 382.9272 387.2538 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 382.9272 366.4425 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 439.6201 387.2538 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 439.6201 366.4425 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 524.6594 366.4425 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 303.3071 366.1925 cm 0 0 m 79.62 0 l S Q q 1 0 0 1 303.5571 345.3812 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 382.9272 366.1925 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 382.9272 345.3812 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 439.6201 366.1925 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 439.6201 345.3812 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 524.6594 345.3812 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 303.3071 345.1312 cm 0 0 m 79.62 0 l S Q q 1 0 0 1 303.5571 324.3199 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 382.9272 345.1312 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 382.9272 324.3199 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 439.6201 345.1312 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 439.6201 324.3199 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 524.6594 324.3199 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 303.3071 324.0699 cm 0 0 m 79.62 0 l S Q q 1 0 0 1 303.5571 312.8587 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 382.9272 324.0699 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 382.9272 312.8587 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 439.6201 324.0699 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 439.6201 312.8587 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 312.8587 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 303.3071 312.6087 cm 0 0 m 79.62 0 l S Q q 1 0 0 1 303.5571 301.3974 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 382.9272 312.6087 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 382.9272 301.3974 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 439.6201 312.6087 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 439.6201 301.3974 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 301.3974 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 303.3071 301.1474 cm 0 0 m 79.62 0 l S Q q 1 0 0 1 382.9272 301.1474 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 439.6201 301.1474 cm 0 0 m 85.289 0 l S Q BT /GS1 gs /T1_2 1 Tf 8 0 0 8 334.2742 680.1465 Tm (\020\t\212\013)Tj 6.517 0.6 Td (\034\217\217\f\r\240\002\004\b\t\235)Tj -0.007 Tw -0.081 -1.2 Td (N)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (43 \(100%\))Tj 0 Tw 10 0.6 Td (\034\217\003\002\201\b\t\220)Tj /T1_0 1 Tf -19.922 -2.033 Td (\230\017\023 \236\236)Tj 0 -1.433 TD (\204\026\001\017\027\027\024\036 \024\002\031\004\036\027\017\036 )Tj 0 -1.2 TD (\(\204\210\))Tj 10.273 1.2 Td (43/43)Tj /Span<>> BDC ( )Tj EMC (\(100%\))Tj 10.298 0 Td ([1\22642])Tj -20.57 -2.633 Td (\206\035\031\002\024\022\024\036 \024\002\031\004\036\027\017\036 )Tj T* (\(\206\210\))Tj 11.023 1.2 Td (3/43)Tj /Span<>> BDC ( )Tj EMC (\(7%\))Tj 9.141 0 Td ([6,18,43])Tj -20.164 -2.633 Td (\202\035\020\024\030\017\021\n\t/\n\024\007\036\035\017/\n\036\021\024\007\ \t \236\236)Tj 0 -1.433 TD (Random Forest)Tj 10.523 0 Td (29/43)Tj /Span<>> BDC ( )Tj EMC (\(67%\))Tj 7.095 0 Td ([1, 2, 4\22612, 14, 18, 20, )Tj -0.532 -1.2 Td (21, 23-28, 30, 32\22635, 40, )Tj 3.488 -1.2 Td (42, 43])Tj -20.575 -1.433 Td (Support Vector )Tj 0 -1.2 TD (Machine)Tj 10.523 1.2 Td (22/43)Tj /Span<>> BDC ( )Tj EMC (\(51%\))Tj 7.026 0 Td ([1\2265, 7\22610, 12, 15, 18, )Tj -0.427 -1.2 Td (20, 21, 23, 27, 30, 32, 35, )Tj 3.383 -1.2 Td (41\22643])Tj -20.506 -1.433 Td (Logistic Regression)Tj 10.523 0 Td (16/43)Tj /Span<>> BDC ( )Tj EMC (\(37%\))Tj 6.817 0 Td ([1, 2, 4\2266, 8\22612, 18, 20, )Tj 1.816 -1.2 Td (26, 34, 41, 42])Tj -19.157 -1.433 Td (XG Boost)Tj 10.523 0 Td (16/43)Tj /Span<>> BDC ( )Tj EMC (\(37%\))Tj 6.595 0 Td ([8, 10\22612, 14, 17, 24, 26, )Tj 0.551 -1.2 Td (27, 29, 30, 32, 34\22637])Tj -17.67 -1.433 Td (Naive Bayes)Tj 10.773 0 Td (7/43)Tj /Span<>> BDC ( )Tj EMC (\(16%\))Tj 6.572 0 Td ([4, 8, 14, 18, 21, 25, 41])Tj -17.345 -1.433 Td (Arti\251cial Neural )Tj T* (Networks \(ANN/DNN\))Tj 10.523 1.2 Td (11/43)Tj /Span<>> BDC ( )Tj EMC (\(26%\))Tj 7.164 0 Td ([4, 6, 9, 12, 18, 19, 23, )Tj 2.178 -1.2 Td (34, 41, 43])Tj -19.866 -1.433 Td (Decision Tree)Tj 10.523 0 Td (15/43)Tj /Span<>> BDC ( )Tj EMC (\(35%\))Tj 7.92 0 0 8 442.6155 462.8724 Tm ([5, 6, 8, 10, 12, 15, 20, 21, )Tj 0.691 -1.2 Td (24, 25, 30, 32, 41\22643])Tj 8 0 0 8 306.3917 441.8111 Tm (Cat Boost)Tj 11.023 0 Td (3/43)Tj /Span<>> BDC ( )Tj EMC (\(7%\))Tj 8.908 0 Td ([7, 13, 24])Tj -19.931 -1.433 Td (Auto-AI )Tj T* (\(\026\r\021\024\n\026\021\017\017\030\024\r\026\027\027\t\005 )Tj T* (\023\036\030\036\002\024\030 \n\024\007\036\035\036\005\))Tj 11.023 2.4 Td (1/43)Tj /Span<>> BDC ( )Tj EMC (\(2%\))Tj 10.076 0 Td ([22])Tj -21.099 -3.833 Td (K-Nearest Neighbors )Tj T* (Algorithm)Tj 10.523 1.2 Td (14/43)Tj /Span<>> BDC ( )Tj EMC (\(33%\))Tj 6.914 0 Td ([8, 9, 12, 15, 21, 23, 24, )Tj 0.301 -1.2 Td (26, 27, 34, 35, 42, 43])Tj -17.739 -1.433 Td (Extreme gradient )Tj T* (boosting model)Tj 11.023 1.2 Td (4/43)Tj /Span<>> BDC ( )Tj EMC (\(9%\))Tj 8.449 0 Td ([1, 2, 13, 20])Tj -19.472 -2.633 Td (Gradient Boosting)Tj 10.773 0 Td (9/43)Tj /Span<>> BDC ( )Tj EMC (\(21%\))Tj 6.664 0 Td ([6, 8, 16, 20, 21, 24, 37, )Tj 3.137 -1.2 Td (38, 40])Tj -20.575 -1.433 Td (Light GBM)Tj 10.773 0 Td (8/43)Tj /Span<>> BDC ( )Tj EMC (\(19%\))Tj 7.123 0 Td ([8, 16, 20, 21, 24, 26, )Tj 2.678 -1.2 Td (39, 41])Tj -20.575 -1.433 Td (mboost)Tj 11.023 0 Td (1/43)Tj /Span<>> BDC ( )Tj EMC (\(2%\))Tj 10.326 0 Td ([6])Tj -21.349 -1.433 Td (Ada Boost)Tj 11.023 0 Td (3/43)Tj /Span<>> BDC ( )Tj EMC (\(7%\))Tj 9.158 0 Td ([7, 9, 25])Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\007\003\032)50(\n\n\217\n)-21(\035\030\002)]TJ 53.418 0 Td [(MET)30(A)-41(-)-41.9(ANAL)30(Y)30(SIS)]TJ -53.418 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 2)69(4, \023\0224, 202)23(5)]TJ 43.013 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 2)69(4, \023\0224, 202)23(5)]TJ /T1_5 1 Tf 25 0 0 25 20.7902 56.0378 Tm (128)Tj ET endstream endobj 1512 0 obj <>stream Adobed     '$''''$25552;;;;;;;;;;   ####''',,,   ####''',,,   ####''',,,;""   {!3t1AQSa"#$%T24C &'()*56789:BDEFGHIJRUVWXYZbcdefghijqrsuvwxyzy!1A"Q2aqr#BRbDTc  $%&'()*3456789:CEFGHIJSUVWXYZdefghijstuvwxyz?uINob sZ~'VLSEMjq#%%s:m'i6fipynQsZ~'VN9?J)x IIQ٧5RudӚ:L!I4?<4?<4Q4*NsZ~'VR1))&G&GF?f֟IՓNkOҤBSݴ? b}{DZ S4PԴ~ 7|qN[s4_5Km)I^؊# c+\ s=8tb;kӦ];inYKkCƋ{[%v!-\i`RudӚ:*1Njm9 v <Bq|g23I. 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""")oi/Wc{OzP""";Ν1u """)oi/Wc{GzP""";Ν1u """)oi/Wc{OzP""";Ν1u """)oi/Wc{OzP""";Ν1u """)oi/Wc{GzP""";Ν1u """)oi/Wc{OzP"""x8OQ*4DDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDD8nhՂl 1㟾f`f̠cu9 =9 %>stream endstream endobj 1510 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\030\b\017\200\b\b)-9.9(\026\r\016\215\215\220\207 \021\215\026)11.1(\016\t\t\016\017)-10(\026 \211)-20.9(\t\004 \222\201\025\202\215\025)21(\213\021\201\025\r\001\215\021\004 )]TJ 0 -1 TD [(\025\026)11(\211\001\t\016\215\215\220 \201\016\213)21(\200\t\214)21(\026)11(\001\026)11(\025\r \t\016\f\016\215\021\004 \235\025\t\214\215\220 \017)10(\025\t\025\201\016\017)-9.9(\026)11(\001\t\214\215\220\024 )]TJ T* [(\201\001\017)10(\025\024 \(\b\021\b)-10(\026)11(\016\024\001\026\021\f\016\b\017\021\207 \025\235\213\025\201 \021\022\024\ \016\026)11(\001\001\215\001\t\021\213\))]TJ 34.456 2 Td [(Ar)-20(tif)-21(icial intelligence for pr)31(edicting long-term outcomes in patients )]TJ 1.361 -1 Td [(with color)31(ectal cancer \(a\022s)10(y)10(stematic r)31(e)11(vie)11(w and meta-analy)10(sis\))]TJ /T1_1 1 Tf 0.01 Tc 0.018 Tw 14 0 0 14 42.5896 724.8299 Tm [(\240)21(\026)45(\024\034\033\031\026)-10(\r\232)5( \031)5(\016)-18.3(\240\034)-31(\024)35(\037\226\232)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf 0 Tc 0.128 Tw 10 0 0 10 42.5197 700.4739 Tm [(\215\024\017\f\022 )0.5(\027\026\031\004\027\t\b )0.6(\023\031\002\035\017\022\026\006\017\005 )0.6(\024\f\031\013\036\f\021\r\035\016\035\f\016 )0.6(\f)]TJ /Span<>> BDC ( )Tj EMC 19.277 0 Td (\031\004\036\021\024\n )Tj 0.261 Tw -19.277 -1.218 Td (\f\021\026\021\036\005, \024\023\031\002\035\017\022\024\r\026\027\027\t\ \b \r)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\017\024\007 \f)Tj /Span<>> BDC ( )Tj EMC (2015 \023\024)Tj /Span<>> BDC ( )Tj EMC (2024 )Tj 0.222 Tw 0 -1.218 TD (\020\020., \r)Tj /Span<>> BDC ( )Tj EMC [(\023\016\021\017 )0.5(\r\036\007\031\013\017\b )0.5(\024\027\035\026\005\027-\002\026\026\b )0.5(\007\026\027\027\t\b: P)20(ubMed, )]TJ 0.391 Tw T* [(S)-24(c)-24(ienceDir)-23.9(ec)-16(t, MedRXi)-15.9(v, BioRXi)-15.9(v \017)]TJ /Span<>> BDC ( )Tj EMC [(Go)-16(o)-16(gle S)-24(chol)-15.9(ar. )]TJ 0.19 Tw T* [(\210\f\027\024\r\027\024\005 \023\024\017\f\022\024\r\t\005 \026\023\030\ \024\f \002\t\035 \253\(\237Ar)-21.9(t)-32(i\251c)-24(ial intel)]TJ 0 Tw (-)Tj 0.027 Tw 0 -1.218 TD [(l)-31(igence\241 OR \237Ma)-17(chine lear)-15(ning\241 OR \237Deep lear)-14.9(ning\241 OR )]TJ 0.159 Tw 0 -1.218 TD [(\237super)-32(v)-15.9(ised lear)-15(ning\241 OR \237unsuper)-31.9(v)-16(ised lear)-15(ning\241 OR )]TJ 0.351 Tw T* [(\237r)-24(einfor)-31.9(cement lear)-15(ning\241\) A)51(ND \(\237Col)30(or)-23.9(ec)-16(t)15(al Cancer\241 )]TJ -0.001 Tw T* [(OR \237R)12.9(ec)-15.9(t)15(al Cancer\241 OR \237Col)30.1(or)-24(ec)-16(t)15(al adeno)-16(car)-32(c)-24(inoma\241 OR )]TJ 0.012 Tw T* [(\237Col)30(on Cancer\241\) A)51.1(ND \(dia)-17(gnos* OR de)-12(tec)-15.9(t* OR p)24.9(r)-23.9(edic)-16(t* )]TJ 0.094 Tw 0 -1.218 TD [(OR scr)-24(een*\)\273. \212\026\027\027\t\005 \026\023\030\024\f \023\030\017\n\036\ \027\016\035\f\016 \023\030\017)]TJ /Span<>> BDC ( )Tj EMC (\023\024\017\f)Tj 0 Tw (-)Tj 0.089 Tw 0 -1.218 TD [(\022\036 )0.6(\r)]TJ /Span<>> BDC ( )Tj EMC 2.045 0 Td [(P)20(ubMed )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC 4.304 0 Td [(Go)-16(o)-16(gle )0.6(S)-24(chol)-16(ar. )0.7(\210\007\027\026\022\024 )0.5(\017-\026 )0.7(\024\020\030\026\027\017)]TJ 0 Tw (-)Tj 0.06 Tw -6.349 -1.218 Td (\004\036\027\017\005 \023\024)Tj /Span<>> BDC ( )Tj EMC (\022\024\035\017\004\036\f\021\r\031 \f\017\n\r\024\035\024\r, \024\027 \ \027\036 \017\f\023\024\035\034\024\r\026\035\f\016 )Tj 0.198 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC [(\007\030\031\020\017\b \002\026\026\b \007\026\027\027\t\b. \212\035\016\ S)-24(c)-24(ienceDir)-23.9(ec)-16(t, MedRxi)-16(v )]TJ 0.097 Tw 0 -1.218 TD (\017)Tj /Span<>> BDC ( )Tj EMC [(BioRxi)-16(v \023\030\017\n\036\027\016\035\f\016 \023\024\017\f\022\024\r\t\005 \026\ \023\030\024\f: \(\237Ar)-21.9(t)-32(i\251c)-24(ial )]TJ 0.165 Tw 0 -1.218 TD [(intell)-30.9(igence\241 OR \237Ma)-17(chine )0.5(lear)-15(ning\241 OR )0.5(\237Deep lear)-15(n)]TJ 0 Tw (-)Tj 0.186 Tw 0 -1.218 TD [(ing\241\) A)51(ND \(\237Col)30(or)-23.9(ec)-16(t)15(al Cancer\241 A)51(ND \237R)13(ec)-16(t)15(al Cancer\241\) )]TJ 0.167 Tw 0 -1.218 TD [(A)51(ND \(p)25(r)-24(edic)-16(t\). \200)]TJ /Span<>> BDC ( )Tj EMC (\220\021\024\021 \024\002\024\030 \r\024\001\035\017 \021\024\035\034\022\ \024 \017\f\f\035\036\007\024)Tj 0 Tw (-)Tj 0.079 Tw T* (\r\026\027\017\016, \023\024\f\r\016\013\036\027\027\t\036 \n\036\021\024\ \007\026\n \236\236, \017\f\023\024\035\034\031\036\n\t\n \007\035\016 \ )Tj 0.121 Tw 0 -1.218 TD (\023\030\024\020\027\024\017\030\024\r\026\027\017\016 \030\017\f\022\026\ \030\036\006\017\007\017\r\026 \017\035\017 \023\030\024\020\030\036\f\f\ \017\030\024)Tj 0 Tw (-)Tj 0 -1.218 TD (\r\026\027\017\016 \022\024\035\024\030\036\022\021\026\035\034\027\024\020\ \024 \030\026\022\026.)Tj 0.235 Tw 0 -1.218 TD (\200 \017\f\f\035\036\007\024\r\026\027\017\036 \002\t\035\017 \r\022\035\ \033\004\036\027\t \024\030\017\020\017\027\026\035\034\027\t\036 \017\f\ )Tj 0 Tw (-)Tj 0.113 Tw T* (\f\035\036\007\024\r\026\027\017\016, \017)Tj /Span<>> BDC ( )Tj EMC (\017\f\022\035\033\004\036\027\t \022\035\017\027\017\004\036\f\022\017\036\ \027\026\002\035\033\007\036\027\017\016, )Tj 0.119 Tw T* [(\024\002\024\030\t )0.5(\035\017\021\036\030\026\021\031\030\t, )0.6(\007\024\022\035\026\007\t )0.5(\022\024\027\235\036\030\036\027\006\017\005. )0.6(\204\t )0.6(\021\026\022)]TJ 0 Tw (-)Tj 0.072 Tw T* [(\032\036 )0.5(\017\f\022\035\033\004\017\035\017 )0.6(\017\f\f\035\036\007\024\r\026\027\017\016, )0.6(\r)]TJ /Span<>> BDC ( )Tj EMC 13.316 0 Td [(\022\024\021\024\030\t\b )0.5(\017\f\023\024\035\034\024\r\026)]TJ 0 Tw (-)Tj 0.147 Tw -13.316 -1.218 Td [(\035\017\f\034 )0.5(\n\036\021\024\007\t, \027\036 )0.5(\f\r\016\026\027\027\t\036 )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC 12.775 0 Td [(\236\236. )0.5(\025\030\024\n\036 \021\024\020\024, )0.5(\002\t\035\017 )]TJ 0.543 Tw -12.775 -1.218 Td [(\017\f\022\035\033\004\036\027\t )0.6(\017\f\f\035\036\007\024\r\026\027\017\016, )0.5(\023\030\036\007\024\f\021\026\r\035\016\033\013\017\036 )0.6(\021\036\024)]TJ 0 Tw (-)Tj 0.249 Tw T* (\030\036\021\017\004\036\f\022\031\033 \024\f\027\024\r\031 \007\035\016\ \n\024\007\036\035\036\005 \236\236, \023\030\017\n\036\027\016\036\n\t\ \b )Tj 0.231 Tw T* (\022)Tj /Span<>> BDC ( )Tj EMC (\022\024\035\024\030\036\022\021\026\035\034\027\024\n\031 \030\026\022\031\ . \212\035\016 \007\026\027\027\024\020\024 \024\002\024\030\026 \030\026\ \f)Tj 0 Tw (-)Tj 0.026 Tw T* (\f\n\026\021\030\017\r\026\035\017\f\034 \021\024\035\034\022\024 \017\f\ \f\035\036\007\024\r\026\027\017\016, \024\023\031\002\035\017\022\024\r\ \026\027\027\t\036 )Tj 0 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC (\026\027\020\035\017\005\f\022\024\n \016\t\022\036.)Tj 0.17 Tw T* (\215\030\024\006\036\f\f \024\021\002\024\030\026 \017\f\f\035\036\007\024\ \r\026\027\017\005 \f\024\f\021\024\016\035 \017)Tj /Span<>> BDC ( )Tj EMC (\021\030\036\b \220\021\026)Tj 0 Tw (-)Tj 0.082 Tw T* (\023\024\r. \203\026)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\r\024\n \220\021\026\023\036 \n\t \023\030\024\r\036\035\017\ \023\024\017\f\022 \035\017\021\036\030\026\021\031\030\t )Tj 0.087 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\r\t\001\036\031\023\024\n\016\027\031\021\t\b \002\026\026\b \007\026\027\ \027\t\b, \026\021\036\n \017\f\023\024\035\034\024\r\026)Tj 0 Tw (-)Tj T* [(\035\017 R)-10(a)15.1(yy)21.9(an )0.5(\007\035\016 \031\007\026\035\036\027\017\016 )0.5(\007\031\002\035\017\022\026\021\024\r )0.5(\r\f\036\b \r\t\016\r\035\036\027\027\t\b )]TJ 0.025 Tw T* (\017\f\f\035\036\007\024\r\026\027\017\005. \203\026)Tj /Span<>> BDC ( )Tj EMC (\r\021\024\030\024\n \220\021\026\023\036 \007\r\026 \027\036\026\r\017\ \f\017\n\t\b \030\036)Tj 0 Tw (-)Tj 0.139 Tw T* (\006\036\027\036\027\021\026 \023\030\024\026\027\026\035\017\017\030\024\ \r\026\035\017 \026\020\024\035\024\r\022\017 \017)Tj /Span<>> BDC ( )Tj EMC (\026\027\027\024\021\026\006\017\017 )Tj 0.16 Tw T* (\r\f\036\b \027\026\005\007\036\027\027\t\b \f\021\026\021\036\005, \017\ \f\022\035\033\004\017\r \017\f\f\035\036\007\024\r\026\027\017\016, \027\ \036 )Tj 0.245 Tw T* (\f\024\024\021\r\036\021\f\021\r\031\033\013\017\036 \021\036\n\036 \024\ \002\024\030\026. \203\026)Tj /Span<>> BDC ( )Tj EMC (\026\022\035\033\004\017\021\036\035\034\027\024\n )Tj 0.215 Tw T* (\220\021\026\023\036 \030\036\006\036\027\036\027\021\t \027\036\026\r\ \017\f\017\n\024 \030\026\f\f\n\024\021\030\036\035\017 \023\024\035\027\ \t\036 )Tj 0.221 Tw T* (\021\036\022\f\021\t \f\021\026\021\036\005, \023\030\024\001\036\007\001\ \017\b \023\030\036\007\t\007\031\013\017\005 \220\021\026\023, \026)Tj /Span<>> BDC ( )Tj EMC (\r\f\036 )Tj 0.408 Tw 0 -1.218 TD [(\027\036\f\024\024\021\r\036\021\f\021\r\017\016 )0.6(\n\036\032\007\031 )0.5(\030\036\006\036\027\036\027\021\026\n\017 )0.5(\030\026\030\036\001\026\035\017\f\034 )]TJ 0 Tw 0 -1.218 TD (\r)Tj /Span<>> BDC ( )Tj EMC (\b\024\007\036 \024\002\f\031\032\007\036\027\017\016.)Tj 0.183 Tw 0 -1.218 TD (\212\035\016 \024\006\036\027\022\017 \024\002\024\002\013\201\027\027\024\ \005 \007\017\026\020\027\024\f\021\017\004\036\f\022\024\005 \021\024\004\ \027\024\f\021\017 )Tj 0.049 Tw T* (\n\024\007\036\035\036\005 \n\026\001\017\027\027\024\020\024 \024\002\031\ \004\036\027\017\016, \023\030\036\007\027\026\027\026\004\036\027\027\t\ \b \007\035\016 )Tj 0.35 Tw T* (\023\030\024\020\027\024\017\030\024\r\026\027\017\016 \024\002\013\036\ \005 \r\t\032\017\r\026\036\n\024\f\021\017 \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027)Tj 0 Tw (-)Tj 0.159 Tw 0 -1.218 TD (\021\024\r, \002\t\035 \023\030\024\r\036\007\036\027 \n\036\021\026\026\ \027\026\035\017 12-\021\017 \017\f\f\035\036\007\024\r\026\027\017\005\ . )Tj 0.399 Tw 0 -1.218 TD (\200)Tj /Span<>> BDC ( )Tj EMC [(\022\026\032\007\024\n \017\f\f\035\036\007\024\r\026\027\017\017 )0.5(\026\027\026\035\017\017\030\024\r\026\035\026\f\034 \n\024\007\036\035\ \034 )]TJ 0 Tw 0 -1.218 TD (\f)Tj /Span<>> BDC ( )Tj EMC [(\027\026\017\035\031\004\001\017\n \027\026\004\036\027\017\036\n \023\035\ \024\013\026\007\017 \023\024\007 \022\030\017\r\024\005 \(A)17.3(UC\).)]TJ /T1_3 1 Tf 0 -1.218 TD (\026\007\002\b\005 \235\020\002\002\240\255)Tj /T1_2 1 Tf -0.008 Tw 0 -1.218 TD (\215\024\f\035\036 \017\r\035\036\004\036\027\017\016 \007\026\027\027\t\ \b \017)Tj /Span<>> BDC ( )Tj EMC (\r\022\035\033\004\201\027\027\t\b \017\f\f\035\036\007\024\r\026)Tj 0 Tw (-)Tj 0.086 Tw 0 -1.218 TD [(\027\017\005 )0.5(\002\t\035 )0.5(\017\f\023\024\035\034\024\r\026\027 )0.5(\023\024\007\b\024\007 )0.5(\027\026\030\030\026\021\017\r\027\024\020\024 )0.6(\f\017\027\021\036\026. )]TJ -0.048 Tw 23.244 64.543 Td (\224\017\027\021\036 \f\031\n\n\017\030\024\r\026\035 \017)Tj /Span<>> BDC ( )Tj EMC (\024\023\017\f\t\r\026\035 \n\036\021\024\007\t \017\f\022\031\f\f\021\r\ \036\027\027\024)Tj 0 Tw (-)Tj 0.017 Tw T* (\020\024 \017\027\021\036\035\035\036\022\021\026, \023\030\017\n\036\027\ \201\027\027\t\036 \r)Tj /Span<>> BDC ( )Tj EMC (\017\f\f\035\036\007\024\r\026\027\017\016\b, \f\024\f\030\036)Tj 0 Tw (-)Tj 0.057 Tw T* [(\007\024\021\024\004\017\r\001\017\f\034 )0.6(\027\026)]TJ /Span<>> BDC ( )Tj EMC 6.955 0 Td [(\017\b )0.5(\006\036\035\016\b, )0.6(\b\026\030\026\022\021\036\030\017\f\021\017\022\026\b, )0.6(\017\f\021\024\004\027\017)]TJ 0 Tw (-)Tj 0.101 Tw -6.955 -1.218 Td (\022\026\b \007\026\027\027\t\b \017)Tj /Span<>> BDC ( )Tj EMC [(\026\035\020\024\030\017\021\n\026\b \(\027\026\023\030\017\n\036\030, R\ )-10(and)-16(om F)10(or)-24(est, )]TJ 0.03 Tw T* [(Suppor)-22(t V)30(ec)-16(t)17(or Ma)-17(chine \017)]TJ /Span<>> BDC ( )Tj EMC [(\007\030.\). \215\024\n\017\n\024 A)17(UC \007\024\023\024\035\027\017)]TJ 0 Tw (-)Tj 0.12 Tw T* [(\021\036\035\034\027\024 \024\006\036\027\017\r\026\035\017 a)-17(ccur)-33(a)-17(cy \(\024\002\013\026\016 \021\024\004\027\024\f\021\034\), sensi)]TJ 0 Tw (-)Tj 0.078 Tw T* [(t)-32(i)-16(v)-15.9(i)-24(t)-10(y )0.6(/ )0.5(r)-23.9(ecall )0.5(\(\004\031\r\f\021\r\017\021\036\035\034\027\024\f\021\034 )0.6(/ )0.6(\023\024\035\027\024\021\031\), )0.6(spec)-23.9(i\251c)]TJ 0 Tw (-)Tj -0.006 Tw 0 -1.218 TD [(i)-24(t)-10(y )0.5(\(\f\023\036\006\017\235\017\004\027\024\f\021\034\), )0.6(p)25(r)-23.9(ec)-24(ision )0.5(/ )0.5(PPV )0.5(\(\023\024\035\024\032\017\021\036\035\034\027\031\033 )]TJ 0.565 Tw 0 -1.218 TD (\023\030\024\020\027\024\f\021\017\004\036\f\022\031\033 \006\036\027\027\ \024\f\021\034\), NPV \(\024\021\030\017\006\026\021\036\035\034\027\031\ \033 )Tj 0.217 Tw T* [(\023\030\024\020\027\024\f\021\017\004\036\f\022\031\033 \006\036\027\027\ \024\f\021\034\), F1-scor)-24(e \(\f\030\036\007\027\036\036 \021\024\004)]TJ 0 Tw (-)Tj 0.048 Tw T* (\027\024\f\021\017 \017)Tj /Span<>> BDC ( )Tj EMC [(\023\024\035\027\024\021\t\), C-inde)-18(x \(\017\027\007\036\022\f \022\024\027\022\024\030\007\026\027\021\027\024\ \f\021\017\) )]TJ 0.023 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (HR \(\024\021\027\024\001\036\027\017\036 \030\017\f\022\024\r\). \025\030\ \024\n\036 \021\024\020\024, \n\024\007\036\035\017 \017\f\022\031\f)Tj 0 Tw (-)Tj 0.084 Tw 0 -1.218 TD (\f\021\r\036\027\027\024\020\024 \017\027\021\036\035\035\036\022\021\026\ \002\t\035\017 \f\024\023\024\f\021\026\r\035\036\027\t \023\024)Tj /Span<>> BDC ( )Tj EMC (\022\035\033\004\036)Tj 0 Tw (-)Tj 0.259 Tw 0 -1.218 TD (\r\t\n \023\026\030\026\n\036\021\030\026\n: \021\017\023\031 \026\035\020\ \024\030\017\021\n\026, \b\026\030\026\022\021\036\030\017\f\021\017\022\ \026\n )Tj 0.044 Tw 0 -1.218 TD (\017\f\b\024\007\027\t\b \007\026\027\027\t\b \(\030\026\n\036\030 \r\t\ \002\024\030\022\017, \r\017\007 \022\035\017\027\017\004\036\f\022\024)Tj 0 Tw (-)Tj 0.185 Tw 0 -1.218 TD (\020\024 \017\f\b\024\007\026\) \017)Tj /Span<>> BDC ( )Tj EMC (\027\026\002\024\030\031 \023\024\022\026\026\021\036\035\036\005 \022\026\ \004\036\f\021\r\026 \n\024\007\036\035\017. )Tj 0.043 Tw 0 -1.218 TD (\211\023\030\026\r\035\036\027\017\036 \r\f\036\n\017 \017\r\035\036\004\ \201\027\027\t\n\017 \007\026\027\027\t\n\017 \027\026)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\021\016)Tj 0 Tw (-)Tj 0 -1.218 TD (\032\036\027\017\017 \f\017\027\021\036\026 \024\f\031\013\036\f\021\r\035\ \016\035\017 \r)Tj /Span<>> BDC ( )Tj EMC [(Micr)-31.7(osof)-28(t E)35(x)-12.9(cel.)]TJ /T1_3 1 Tf 0 -2.436 TD (\026\b\020\b\007\017\b\007\006\005\017\004\007\003 \020\002\020\001\007\ )Tj /T1_2 1 Tf 0.184 Tw 0 -1.218 TD [(\224\021\026\021\017\f\021\017\004\036\f\022\031\033 )0.5(\024\002\030\026\002\024\021\022\031 \007\026\027\027\t\b \n\036\021\026\ \026\027\026\035\017\026 )0.5(\r\t)]TJ 0 Tw (-)Tj 0.158 Tw 0 -1.218 TD (\023\024\035\027\016\035\017 \r)Tj /Span<>> BDC ( )Tj EMC [(RS)15(tudio \(R v. 4.4.2; R Cor)-24(e T)40(eam, V)-15(ienna, )]TJ 0.193 Tw 0 -1.218 TD [(A)10(ustr)-36.9(ia\) \f)]TJ /Span<>> BDC ( )Tj EMC [(\017\f\023\024\035\034\024\r\026\027\017\036\n \023\026\022\036\021\026\ me)-12(t)15(afor v. 4.8-0. )]TJ 0.138 Tw 0 -1.218 TD (\236\f\b\024\007\016 \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\036\007\023\024\035\024\032\036\027\017\016 \024)Tj /Span<>> BDC ( )Tj EMC (\n\036\032\017\f\f\035\036\007\024\r\026\021\036\035\034\f\022\024\005 )Tj 0.182 Tw T* (\020\036\021\036\030\024\020\036\027\027\024\f\021\017, \024\002\255\036\ \007\017\027\201\027\027\t\005 \220\235\235\036\022\021 \030\026\f\f\004\ \017\021\t\r\026)Tj 0 Tw (-)Tj 0.089 Tw T* (\035\017 \023\024)Tj /Span<>> BDC ( )Tj EMC (\n\024\007\036\035\017 \f\035\031\004\026\005\027\t\b \220\235\235\036\022\ \021\024\r. \211\030\024\r\036\027\034 \020\036\021\036\030\024)Tj 0 Tw (-)Tj 0.158 Tw T* (\020\036\027\027\024\f\021\017 \024\006\036\027\017\r\026\035\017 \023\024\ )Tj /Span<>> BDC ( )Tj EMC (\f\021\026\021\017\f\021\017\022\026\n \266\262, I\262 \017)Tj /Span<>> BDC ( )Tj EMC (Q-\021\036\f\021\031 )Tj -0.094 Tw T* (\025\024\022\030\026\027\026; \027\026\004\036\027\017\016 I\262 \f\r\t\ \001\036 50% \021\030\026\022\021\024\r\026\035\017 \022\026\022 \r\t\f\024\ )Tj 0 Tw (-)Tj T* (\022\031\033 \020\036\021\036\030\024\020\036\027\027\024\f\021\034. \212\ \035\016 \r\017\031\026\035\017\026\006\017\017 \017\027\007\017\r\017\ \007\031\026\035\034)Tj (-)Tj 0.064 Tw T* [(\027\t\b )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC [(\f\024\r\024\022\031\023\027\t\b \024\006\036\027\024\022 )0.5(\002\t\035 \023\024\f\021\030\024\036\027 )0.5(\035\036\f\024\r\017\007\027\t\005 )]TJ 0.348 Tw T* [(\020\030\026\235\017\022 \(for)-23.9(est pl)30(o)17(ts\), \200\024\n\024\032\027\024\036 \023\031\002\035\017\022\026\006\017\ \024\027\027\024\036 )]TJ 0.034 Tw T* (\f\n\036\013\036\027\017\036 \023\030\024\r\036\030\016\035\017 \023\030\ \017)Tj /Span<>> BDC ( )Tj EMC (\023\024\n\024\013\017 \r\024\030\024\027\022\024\024\002\030\026\027\024\ \020\024 )Tj 0.018 Tw T* [(\020\030\026\235\017\022\026 \(funnel pl)30.1(o)17(ts\). \224)]TJ /Span<>> BDC ( )Tj EMC (\006\036\035\034\033 \024\006\036\027\022\017 \031\f\021\024\005\004\017\ \r\024\f\021\017 )Tj -0.023 Tw T* (\024\002\255\036\007\017\027\201\027\027\024\005 \024\006\036\027\022\017\ , \002\t\035 \023\030\024\r\036\007\201\027 \026\027\026\035\017 \004\031\ \r\f\021\r\017)Tj 0 Tw (-)Tj 0.25 Tw T* (\021\036\035\034\027\024\f\021\017 \f)Tj /Span<>> BDC ( )Tj EMC (\017\f\023\024\035\034\024\r\026\027\017\036\n \n\036\021\024\007\026 l\ eave-one-out: )Tj 0.408 Tw T* [(\023\024\024\004\036\030\201\007\027\024 \017\f\022\035\033\004\026\035\026\ \f\034 )0.5(\022\026\032\007\026\016 \023\031\002\035\017\022\026\006\017\016 )0.5(\007\035\016 )]TJ 0.063 Tw T* (\024\023\030\036\007\036\035\036\027\017\016 \036\201 \r\035\017\016\027\ \017\016 \027\026)Tj /Span<>> BDC ( )Tj EMC [(\017\021\024\020\024\r\031\033 A)17(UC \017)]TJ /Span<>> BDC ( )Tj EMC (\031\030\024\r\036\027\034 )Tj 0.238 Tw T* (\020\036\021\036\030\024\020\036\027\027\024\f\021\017. \230\026\022\032\ \036 \002\t\035 \r\t\023\024\035\027\036\027 \n\024\007\036\030\026\006\017\ \024\027)Tj 0 Tw (-)Tj 0.103 Tw T* (\027\t\005 \026\027\026\035\017 \f)Tj /Span<>> BDC ( )Tj EMC (\021\017\023\024\n \026\035\020\024\030\017\021\n\026 \r)Tj /Span<>> BDC ( )Tj EMC (\022\026\004\036\f\021\r\036 \022\026\021\036\020\024\030\017)Tj 0 Tw (-)Tj 0.129 Tw T* (\026\035\034\027\024\020\024 \n\024\007\036\030\026\021\024\030\026 \007\ \035\016 \r\t\016\f\027\036\027\017\016 \r\022\035\026\007\026 \022\026\032\ \007\024\020\024 )Tj 0 Tw T* (\n\036\021\024\007\026 \r)Tj /Span<>> BDC ( )Tj EMC (\024\002\013\031\033 \r\026\030\017\026\021\017\r\027\024\f\021\034 \030\ \036\031\035\034\021\026\021\024\r.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 275.0305 201.1758 Tm [(\033\034\020)21(\223)50(\r\237)46(\024)52(\026)45(\024\232)]TJ 0 0 0 1 k /GS1 gs /T1_3 1 Tf 0 Tc 0 Tw 10 0 0 10 274.9606 176.8198 Tm (\027\005\202\001\203\b\020\b\240 \204\217\007\017\004\020)Tj /T1_2 1 Tf 0.138 Tw T* [(\215\024 )0.5(\007\026\027\027\t\n )0.6(\023\024\017\f\022\024\r\t\n )0.5(\026\023\030\024\f\026\n )0.5(\002\t\035\024 )0.6(\017\007\036\027\021\017\235\017\006\017)]TJ 0 Tw (-)Tj 0.188 Tw T* (\030\024\r\026\027\024 657106 \f\021\026\021\036\005 \017)Tj /Span<>> BDC ( )Tj EMC [(5-\021\017 \002\026 \007\026\027\027\t\b: P)20(ubMed )]TJ 0 Tw T* (\()Tj /T1_4 1 Tf (n)Tj /T1_2 1 Tf -0.021 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC [(2551\), S)-24(c)-23.9(ience Dir)-24(ec)-16(t \()]TJ /T1_4 1 Tf 0 Tw (n)Tj /T1_2 1 Tf -0.021 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC [(635180\), Go)-16(o)-16(gle S)-24(chol)-16(ar )]TJ 0 Tw T* (\()Tj /T1_4 1 Tf (n)Tj /T1_2 1 Tf -0.038 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC [(18900\), BioRXi)-15.9(v \()]TJ /T1_4 1 Tf 0 Tw (n)Tj /T1_2 1 Tf -0.038 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (345\), \017)Tj /Span<>> BDC ( )Tj EMC [(MedRxi)-16(v \()]TJ /T1_4 1 Tf 0 Tw (n)Tj /T1_2 1 Tf -0.038 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (130\). \200\f\036 )Tj 0.062 Tw T* (\f\021\026\021\034\017 \017)Tj /Span<>> BDC ( )Tj EMC [(\002\026 \007\026\027\027\t\b P)20(ubMed, BioRXi)-15.9(v, MedRxi)-15.9(v \002\t\035\017 )]TJ 0.283 Tw T* (\023\030\024\026\027\026\035\017\017\030\024\r\026\027\t \027\026)Tj /Span<>> BDC ( )Tj EMC (\024\f\027\024\r\036 \031\022\026\026\027\027\024\020\024 \026\023\030\ \024\f\026. )Tj -0.014 Tw T* (\236-\026 \002\024\035\034\001\024\020\024 \024\002\255\036\n\026 \f\021\ \026\021\036\005 \017)Tj /Span<>> BDC ( )Tj EMC [(\002\026 \007\026\027\027\t\b, S)-24(c)-24(ience )]TJ 0.283 Tw T* [(Dir)-24(ec)-16(t \017)]TJ /Span<>> BDC ( )Tj EMC [(Go)-15.9(o)-16(gle S)-24(chol)-16(ar \002\t\035\017 \030\026\f\f\n\024\021\030\036\027\t \021\024\035\034\022\ \024 )]TJ 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 0 Tw 7.5 0 0 7.5 42.5197 759.8869 Tm [(\007\003\032)50(\n\n\217\n)-21(\035\030\002)]TJ 53.418 0 Td [(MET)30(A)-41(-)-41.9(ANAL)30(Y)30(SIS)]TJ /T1_5 1 Tf 25 0 0 25 505.552 56.0378 Tm (127)Tj ET endstream endobj 1509 0 obj <>stream q /GS0 gs /Fm0 Do Q 0 0 0 1 K 1 j 1 J [0 2.997]0 d /GS1 gs q 1 0 0 1 74.3631 495.9842 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 71.3661 495.9842 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q [0 2.997]0 d q 1 0 0 1 74.3631 458.7763 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 71.3661 458.7763 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q 0 j 0 J q 1 0 0 1 70.8661 404.7071 cm 0 0 m 453.543 0 l S Q BT 0 0 0 1 k /T1_0 1 Tf 0.012 Tc 0.387 Tw 9 0 0 9 70.8661 730.4919 Tm [(AIM: )0.5(to)]TJ /Span<>> BDC ( )Tj EMC 3.97 0 Td [(ev)15.7(aluate )0.5(the)]TJ /Span<>> BDC ( )Tj EMC [(per)-34.3(for)-14.3(mance of)]TJ /Span<>> BDC ( )Tj EMC 13.157 0 Td [(ar)-40.3(tif)-43.4(icial-intellig)11.6(ence algor)-37.4(ithms )0.5(in )0.5(p)45.6(redicting )0.5(long-ter)-14.3(m )0.5(treatment )0.5(outcomes)12( )]TJ 0.002 Tc 0.093 Tw -11.772 -1.111 Td [(in patients with colorectal cancer using clinical d)26(ata alone to)]TJ /Span<>> BDC ( )Tj EMC [(ev)16(aluate the)]TJ /Span<>> BDC ( )Tj EMC [(per)-34(for)-14(mance of)]TJ /Span<>> BDC ( )Tj EMC [(ar)-40(tif)-43(icial-intellig)12(ence)2( )]TJ 0.024 Tw 0 -1.111 TD [(algor)-37(ithms in p)46(redicting long-ter)-14(m treatment outcomes in patients with colorectal cancer \(CR)21(C\) using clinical d)26(ata)2( )]TJ -0.002 Tw T* (alone.)Tj 0.01 Tc 0.032 Tw T* [(MA)45(TERIAL)-28(S A)53(ND METHODS: a)]TJ /Span<>> BDC ( )Tj EMC [(systematic search \(2015\2262024\) w)13(as conducted in PubMed, Science Direct, MedRxiv)63(,)10( )]TJ 0.095 Tw 0 -1.111 TD [(BioRxiv and Goog)13(le Scholar)51(. Or)-36.9(iginal studies that applied machine-lear)-14(ning or deep-lear)-14(ning techniq)14(ues e)-15(xclu)]TJ 0 Tc 0 Tw (-)Tj 0.01 Tc 0.175 Tw 0 -1.111 TD [(siv)13(ely )0.5(to)]TJ /Span<>> BDC ( )Tj EMC 3.88 0 Td [(clinical )0.6(v)16(ar)-37(iables )0.5(for )0.6(p)46(redicting )0.5(CR)21(C )0.5(recur)-16(rence )0.5(w)12(ere )0.5(included. )0.5(Of)]TJ /Span<>> BDC ( )Tj EMC 27.34 0 Td [(657106 )0.5(records )0.5(screened, )0.5(43 )0.5(met)10( )]TJ 0.106 Tw -31.22 -1.111 Td (the)Tj /Span<>> BDC ( )Tj EMC [(eligibility cr)-36.9(iter)-37(ia; 12 w)12(ere entered into a)]TJ /Span<>> BDC ( )Tj EMC [(meta-analysis. P)15(ooled area under the)]TJ /Span<>> BDC ( )Tj EMC [(R)19(OC cur)-42(v)12.9(e \(A)29(UC\), hetero)]TJ 0 Tc 0 Tw (-)Tj 0.01 Tc 0.115 Tw T* [(g)12(eneity metr)-37(ics \(I\262, \251\262, Q-test\), publication bias and sensitivity w)12(ere assessed. R)19(obustness w)13(as e)-15(x)10(amined with)10( )]TJ 0.023 Tw T* (a)Tj /Span<>> BDC ( )Tj EMC [(leav)13(e-one-out analysis.)]TJ 0 Tc -0.02 Tw T* [(RESUL)30(T)-10(S: a)]TJ /Span<>> BDC ( )Tj EMC [(systematic search \(2015\2262024\) in PubMed, Science Direct, MedRxiv)63(, BioRxiv and Goog)12.9(le Scholar)51(. Or)-37(iginal )]TJ 0.121 Tw T* [(studies that applied machine-lear)-13.9(ning or deep-lear)-14(ning techniq)14.1(ues e)-15(xclusiv)13(ely to)]TJ /Span<>> BDC ( )Tj EMC [(clinical v)15.9(ar)-37(iables for p)46(redicting )]TJ 0.14 Tw T* [(CR)21(C recur)-16(rence w)12(ere included. Of)]TJ /Span<>> BDC ( )Tj EMC (657106 records screened, 43 met the)Tj /Span<>> BDC ( )Tj EMC [(eligibility cr)-37(iter)-37(ia; 12 w)12(ere entered into )]TJ 0.008 Tw T* (a)Tj /Span<>> BDC ( )Tj EMC [(meta-analysis. P)15(ooled area under the)]TJ /Span<>> BDC ( )Tj EMC [(R)19(OC cur)-42(v)13(e \(A)29(UC\), heterog)12(eneity metr)-37(ics \(I\262, \251\262, Q-test\), publication bias and )]TJ 0.023 Tw 0 -1.111 TD [(sensitivity w)12(ere assessed. R)19(obustness w)13(as e)-15(x)10(amined with a)]TJ /Span<>> BDC ( )Tj EMC [(leav)13(e-one-out analysis.)]TJ 0.015 Tw 0 -1.111 TD [(C)21(ON)22(CLUSION: AI models show p)46(romising accuracy in p)46(redicting colorectal cancer recur)-16(rence, suppor)-40(ting their po)13(ten)]TJ 0 Tw (-)Tj 0.018 Tw T* [(tial )0.5(utility )0.5(in )0.5(clinical )0.5(decision-making. )0.6(N)18(ev)13(er)-40(theless, )0.5(fur)-40(ther )0.5(v)16(alid)26(ation )0.5(in )0.5(larg)12(e-scale, )0.5(p)45.9(rospectiv)13(e )0.5(studies )0.5(is req)14(uired )]TJ 0.023 Tw T* [(before widesp)46(read clinical im)16(plementation.)]TJ /T1_1 1 Tf 0.01 Tc -0.01 Tw 8 0 0 8 70.9061 545.2226 Tm [(KEYW)22(ORDS:)]TJ /T1_0 1 Tf 0 Tc 0.023 Tw 4.948 0 Td [( colorectal cancer; ar)-40(tif)-42.9(icial intellig)12.1(ence; sur)-42(viv)16(al p)46(rediction; machine lear)-13.9(ning; deep lear)-14(ning; meta-analysis)]TJ /T1_1 1 Tf 0.01 Tc 0.018 Tw -4.948 -1.909 Td [(C)19(ONFL)-33(ICT)5( OF)]TJ /Span<>> BDC 5.312 0 Td ( )Tj EMC [(INTE)25(REST)61.9(:)]TJ /T1_0 1 Tf 0 Tc 0.023 Tw 4.559 0 Td ( the)Tj /Span<>> BDC ( )Tj EMC [(authors declare no conf)-22(lict of)]TJ /Span<>> BDC ( )Tj EMC (interest)Tj /T1_1 1 Tf 0.01 Tc -0.01 Tw -9.871 -1.909 Td [(FUNDIN)23(G:)]TJ /T1_0 1 Tf 0 Tc 0 Tw 4.202 0 Td [( this research w)13(as funded by the)]TJ /Span<>> BDC ( )Tj EMC (Analytical Center for the)Tj /Span<>> BDC ( )Tj EMC [(Gov)13(er)-14(nment of)]TJ /Span<>> BDC ( )Tj EMC [(the R)22(ussian F)11(ederation under ag)14(reement N)17(o. 70-2024-000121 )]TJ 0.023 Tw -4.207 -1.2 Td [(d)26(ated March 29, 2024 \(IGK 000000D730324P540002\).)]TJ /T1_1 1 Tf 0.037 Tc -0.006 Tw 0.005 -2.617 Td [(F)3.2(O)-4.6(R)8.7( )0.5(C)-17.5(I)-15.5(T)45.4(A)37.5(T)-24.5(I)-1.3(ON:)]TJ /T1_2 1 Tf 0.023 Tc 0.003 Tw 6.438 0 Td [( )0.5(A)-28.4(b)-22.1(d)-8.9(u)-8.4(l)-37.8(a)-15(e)-15.8(v)-28.4(a )0.5(R)-21.4(.)-26.9(S)-10.3(h)-5.1(.)-23.5(, )0.5(P)-10.3(a)-10.7(v)-28(l)-20.9(o)-10.3(v)-28.4(a)]TJ /Span<>> BDC ( )Tj EMC 11.439 0 Td [(V)39.7(.)-9.8(I)-10.3(.)-23.5(, )0.5(G)-18.4(e)-15.8(v)-15.4(o)-11.8(r)-30.8(k)-45.7(y)-24.2(a)-7.6(n)]TJ /Span<>> BDC ( )Tj EMC 6.801 0 Td [(T)52.5(.)15(G)-11.6(.)-23.5(, )0.5(B)-19.1(e)-18(l)-23.7(e)-11.5(n)-8.8(k)-24.2(a)-14.9(y)-24.2(a)]TJ /Span<>> BDC ( )Tj EMC 6.803 0 Td [(Y)16.3(a)-13.7(.)40.6(V)39.7(.)-23.5(, )0.5(M)-8.7(a)-7.6(n)-7.7(u)-9.6(k)-45.7(y)-24.2(a)-7.6(n )0.5(M)-7.1(.)-26.9(S)-10.3(h)-5.1(.)-23.5(, )0.5(G)-14.2(o)-11.8(r)-18.1(d)-15.3(e)-25.2(e)-15.8(v)]TJ /Span<>> BDC ( )Tj EMC 13.799 0 Td [(S)-9.6(.)-26.9(S)-9.6(. )0.5(A)-13.6(r)-59.7(t)-46.2(i)-12.1(f)-63(i)-5(c)-38.2(i)-5.1(a)-11.4(l )0.5(i)-3.2(n)-17.3(t)-24.7(e)-18(l)-28.4(l)-16.7(i)-6.7(g)-14.5(e)-11.4(n)-10(c)-9.8(e)23( )]TJ 0.098 Tw -45.285 -1.2 Td [(f)-25.2(o)-11.8(r p)-13.7(r)-19.1(e)-21(d)-15.8(i)-5(c)-41.5(t)-46.2(i)-3.2(n)-11.9(g l)-20.9(o)-9.2(n)-11.9(g)-14.8(-)-8.3(t)-24.7(e)-12.1(r)-35.9(m o)-13.3(u)-16.3(t)-22.4(c)-6.4(o)-9.3(m)-16.6(e)-22.8(s i)-3.2(n p)-20(a)-18.2(t)-46.2(i)-10.9(e)-11.5(n)-17.4(t)-48.8(s w)-45.6(i)-15.8(t)-26.1(h c)-6.5(o)-15.6(l)-20.9(o)-11.8(r)-19.1(e)-19.1(c)-41.5(t)-36.8(a)-11.4(l c)-21.5(a)-7.6(n)-10(c)-9.7(e)-12.1(r \()43.2(a s)-30.8(y)-28.9(s)-29.3(t)-24.7(e)-11.5(m)-8.3(a)-18.2(t)-46.2(i)-5(c r)-19.1(e)-15.8(v)-51.8(i)-11(e)-12.5(w a)-7.6(n)-14.5(d m)-16.6(e)-22.3(t)-36.8(a)-19.6(-)-13.1(a)-7.6(n)-7.8(a)-11.4(l)-8.3(y)-28.9(s)-26.1(i)-7.4(s)41.6(\))10.3(. )]TJ /T1_0 1 Tf 0.033 Tc -0.033 Tw [(K)13.9(ol)3.6(op)2.4(r)3.1(o)3.5(k)-19.2(t)2.2(ol)3.6(o)-3.3(g)-13.1(i)6.7(a)5.8(.)]TJ /T1_2 1 Tf 0 Tc 0 Tw 56.693 0 Td ( )Tj 0.023 Tc 0.024 Tw -56.693 -1.2 Td [(2)-8.9(0)-3.8(2)-1.4(5)23.3(;)9.8(2)8.8(4)-13.5(\()40.1(4)30.3(\))14.5(:)20.9(12)-1.4(5)-22.7(\226)50.8(1)-7.9(3)15.4(7)80.1(. \()-0.9(i)-3.2(n R)-6.5(u)-21.9(s)-22.3(s)-15.5(.)43.2(\))10.4(. )0.5(h)-17.3(t)-49.4(t)-29.4(p)-18.6(s)-8(:)1.9(/)84.7(/)36.4(d)-11.1(o)-12.5(i.)2.7(o)-11.8(r)-16.7(g)-22.8(/)11.2(1)14(0)6.5(.)-5.6(3)7.9(3)-15.9(8)1.3(7)4.6(8/)7.9(2)-8.9(0)9.3(7)-2(3)-13.3(-)41.3(7)10.6(5)0.5(5)-9(6)-26.7(-)9.8(2)-8.9(0)-3.9(2)-1.4(5)-23.5(-)9.7(2)8.8(4)-28.5(-)-30.3(4)-28.4(-)55.1(12)-1.4(5)-23.5(-)55.1(1)-7.9(3)15.4(7)]TJ /T1_1 1 Tf 0.01 Tc 0.059 Tw 0.005 -2.617 Td [(\021\024\027\030\026)5( \024\033\023)5( \t\030\027\030\t\032\026\037\032:)]TJ /T1_0 1 Tf 0 Tc 0.064 Tw 10.658 0 Td [( \205\025\b\023\027\037\016\036\037 )0.5(\213\023\021\022\030\035 \245\037\006\022\027\003\016\036\020\037, \216\223\ \210\215 \253\217\214\200\221 \034\020\021\034\027\034\013\022\022 )0.5(\022\006. \217.\217.)]TJ /Span<>> BDC ( )Tj EMC (\210\027\034\002\022\020\037\273 \214\022\020\031\b\033\037\036\037 \213\ \034\024\024\022\022, \023\027.)Tj /Span<>> BDC ( )Tj EMC (\r\037\001\022\033\024\021\034\016 )Tj 0.023 Tw -10.663 -1.2 Td (\001\034\024\024\016, \b.)Tj /Span<>> BDC ( )Tj EMC (23, \214\034\024\021\036\037, e-mail: ruutlevi@gmail.com)Tj /T1_1 1 Tf 0.01 Tc 0.165 Tw 0.005 -1.2 Td [(ADDRESS)5( F)13(OR)5( C)19(ORRESPONDEN)22.9(CE:)]TJ /T1_0 1 Tf 0 Tc 0.17 Tw 14.345 0 Td [( R)22(ukiyat Shamilievna A)12(bdulaev)16.1(a, N)28(.N)28(.)]TJ /Span<>> BDC ( )Tj EMC [(Blokhin N)18(ational Medical R)21(esearch Center of)]TJ /Span<>> BDC ( )Tj EMC [(Oncology)42(, K)17(ashirsk)13(oe )]TJ 0.023 Tw -14.35 -1.2 Td [(shosse, 23, Moscow)52(, R)22(ussia; e-mail: ruutlevi@gmail.com)]TJ 0 Tw 0 -2.792 TD (\n\037\035\037 \f\034\024\035\023\f\027\016\020\022\030)Tj /Span<>> BDC ( )Tj EMC (\227 16.06.2025)Tj /Span<>> BDC ( )Tj EMC 19.488 0 Td (\t\034\024\027\016 \b\034\033\037\025\034\035\021\022)Tj /Span<>> BDC ( )Tj EMC (\227 02.09.2025)Tj /Span<>> BDC ( )Tj EMC 18.78 0 Td (\t\033\022\020\030\035\034 \021)Tj /Span<>> BDC ( )Tj EMC (\f\023\025\027\022\021\037\007\022\022)Tj /Span<>> BDC ( )Tj EMC (\227 10.11.2025)Tj ( )Tj -38.268 -1.375 Td (Received)Tj /Span<>> BDC ( )Tj EMC (\227 16.06.2025)Tj /Span<>> BDC ( )Tj EMC 19.488 0 Td (Revised)Tj /Span<>> BDC ( )Tj EMC (\227 02.09.2025)Tj /Span<>> BDC ( )Tj EMC 18.78 0 Td (Accepted for publication)Tj /Span<>> BDC ( )Tj EMC (\227 10.11.2025)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 70.936 335.1339 Tm (\023\023\034\226\034\022\031\034)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf 0 Tc 0.284 Tw 10 0 0 10 70.8661 310.7779 Tm (\215\030\024\020\027\024\017\030\024\r\026\027\017\036 \024\021\007\026\ \035\036\027\027\t\b \030\036\031\035\034\021\026\021\024\r \035\036\004\ \036\027\017\016 )Tj 0.133 Tw 0 -1.218 TD (\002\024\035\034\027\t\b \022\024\035\024\030\036\022\021\026\035\034\027\ \t\n \030\026\022\024\n \(\025\217\217\) \023\030\036\007\f\021\026\r\035\ \016\036\021 )Tj 0.125 Tw T* (\f\024\002\024\005 \024\007\027\031 \017)Tj /Span<>> BDC ( )Tj EMC (\022\035\033\004\036\r\t\b \026\007\026\004 \024\027\022\024\035\024\020\ \017\017, \023\024\f\022\024\035\034)Tj 0 Tw (-)Tj 0.42 Tw T* (\022\031 \023\024\r\024\035\016\036\021 \023\036\030\f\024\027\026\035\017\ \017\030\024\r\026\021\034 \021\036\030\026\023\036\r\021\017\004\036\f\ \022\017\036 )Tj 0.557 Tw T* (\f\021\030\026\021\036\020\017\017 \017)Tj /Span<>> BDC ( )Tj EMC (\024\023\021\017\n\017\017\030\024\r\026\021\034 \023\024\f\035\036\024\ \023\036\030\026\006\017\024\027\027\t\005 )Tj 0 Tw T* (\n\024\027\017\021\024\030\017\027\020.)Tj 0.441 Tw T* (\224\024\r\030\036\n\036\027\027\t\036 \023\024\007\b\024\007\t \027\026\ )Tj /Span<>> BDC ( )Tj EMC (\024\f\027\024\r\036 \017\f\022\031\f\f\021\r\036\027\027\024\020\024 )Tj 0.14 Tw T* [(\017\027\021\036\035\035\036\022\021\026 \(\236\236\), \r\022\035\033\004\ \026\033\013\017\036 )0.5(\026\035\020\024\030\017\021\n\t \n\026\001\017\027\027\024)]TJ 0 Tw (-)Tj 0.228 Tw T* (\020\024 \024\002\031\004\036\027\017\016 \017)Tj /Span<>> BDC ( )Tj EMC (\020\035\031\002\024\022\024\020\024 \024\002\031\004\036\027\017\016, \023\ \024\r\024\035\016\033\021 \220\235)Tj 0 Tw (-)Tj 0.234 Tw T* (\235\036\022\021\017\r\027\024 \026\027\026\035\017\017\030\024\r\026\021\ \034 \002\024\035\034\001\017\036 \n\026\f\f\017\r\t \007\026\027\027\t\b\ )Tj 0.415 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\031\035\031\004\001\026\021\034 \021\024\004\027\024\f\021\034 \023\030\ \024\020\027\024\026. \224\030\036\007\017 \030\026\035\017\004\027\t\b\ )Tj 0.372 Tw T* [(\r\024\n\024\032\027\t\b \017\f\021\024\004\027\017\022\024\r )0.5(\017\027\235\024\030\n\026\006\017\017 \007\035\016 \026\027\026\035\017\ \026, )]TJ 0.203 Tw T* (\022\035\017\027\017\004\036\f\022\017\036 \007\026\027\027\t\036 \016\r\ \035\016\033\021\f\016 \027\026\017\002\024\035\036\036 \007\024\f\021\031\ \023\027\t)Tj 0 Tw (-)Tj 0.275 Tw T* (\n\017 \017)Tj /Span<>> BDC ( )Tj EMC (\f\021\026\027\007\026\030\021\017\017\030\024\r\026\027\027\t\n\017 \007\ \035\016 \023\030\024\020\027\024\017\030\024\r\026\027\017\016 )Tj 0.235 Tw T* (\024\027\022\024\035\024\020\017\004\036\f\022\017\b \017\f\b\024\007\024\ \r. \200)Tj /Span<>> BDC ( )Tj EMC (\024\021\035\017\004\017\036 \024\021 \n\024\035\036\022\031\035\016\030\ )Tj 0 Tw (-)Tj 0.207 Tw T* (\027\024-\020\036\027\036\021\017\004\036\f\022\017\b \n\026\030\022\036\ \030\024\r, \017\b \f\002\024\030 \027\036 \021\030\036\002\031\036\021 \ \r\t)Tj 0 Tw (-)Tj 0.088 Tw T* (\f\024\022\017\b \026\021\030\026\021 \017)Tj /Span<>> BDC ( )Tj EMC (\f\023\036\006\017\026\035\017\017\030\024\r\026\027\027\024\020\024 \035\ \026\002\024\030\026\021\024\030\027\024\020\024 )Tj 0.076 Tw T* (\024\002\024\030\031\007\024\r\026\027\017\016, \004\021\024 \007\036\035\ \026\036\021 \017\b \001\017\030\024\022\024 \023\030\017\n\036\027\016\036\ \n\t\n\017 )Tj 0.04 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\030\036\026\035\034\027\024\005 \023\030\026\022\021\017\022\036. \025\030\ \024\n\036 \021\024\020\024, \017\f\023\024\035\034\024\r\026\027\017\036\ \017\f)Tj 0 Tw (-)Tj 0.096 Tw T* [(\022\035\033\004\017\021\036\035\034\027\024 )0.6(\022\035\017\027\017\004\036\f\022\017\b )0.6(\023\026\030\026\n\036\021\030\024\r )0.5(\024\002\036\f\023\036\004\017\r\026\036\021 )]TJ 0.009 Tw 23.244 25.574 Td (\035\031\004\001\031\033 \017\027\021\036\030\023\030\036\021\017\030\031\ \036\n\024\f\021\034 \n\024\007\036\035\036\005 \017)Tj /Span<>> BDC ( )Tj EMC (\f\023\024\f\024\002\f\021\r\031\036\021 )Tj 0.163 Tw T* (\017\b \017\027\021\036\020\030\026\006\017\017 \r)Tj /Span<>> BDC ( )Tj EMC (\f\031\013\036\f\021\r\031\033\013\017\036 \023\030\024\021\024\022\024\035\ \t \r\036\007\036\027\017\016 )Tj 0.124 Tw T* (\023\026\006\017\036\027\021\024\r. \203\026)Tj /Span<>> BDC ( )Tj EMC (\f\036\020\024\007\027\016\001\027\017\005 \007\036\027\034 \023\030\017\ \n\036\027\016\033\021\f\016 \030\026)Tj 0 Tw (-)Tj 0.032 Tw T* (\035\017\004\027\t\036 \026\035\020\024\030\017\021\n\t \n\026\001\017\027\ \027\024\020\024 \017)Tj /Span<>> BDC ( )Tj EMC (\020\035\031\002\024\022\024\020\024 \024\002\031\004\036\027\017\016, )Tj 0.093 Tw T* [(\021\026\022\017\036 )0.5(\022\026\022 )0.5(\020\030\026\007\017\036\027\021\027\t\005 )0.6(\002\031\f\021\017\027\020 )0.5(\(X)16(GBo)-15.9(ost, )0.5(L)-32(ightGBM\), )]TJ -0.044 Tw T* [(R)-10(and)-16(om F)10(or)-24(est \017)]TJ /Span<>> BDC ( )Tj EMC (\026\027\f\026\n\002\035\036\r\t\036 \n\036\021\024\007\t. \210\007\027\026\ \022\024 \024\f\021\026\201\021)Tj 0 Tw (-)Tj 0.038 Tw T* [(\f\016 )0.5(\027\036\030\036\001\201\027\027\t\n )0.5(\r\024\023\030\024\f \024)]TJ /Span<>> BDC ( )Tj EMC [(\021\024\n, )0.5(\022\026\022\024\005 \017)]TJ /Span<>> BDC ( )Tj EMC 16.494 0 Td [(\220\021\017\b )0.5(\026\035\020\024\030\017\021)]TJ 0 Tw (-)Tj 0.08 Tw -16.494 -1.218 Td [(\n\024\r )0.5(\027\026\017\002\024\035\036\036 )0.5(\220\235\235\036\022\021\017\r\036\027 )0.6(\007\035\016 )0.5(\026\027\026\035\017\026 )0.6(\022\035\017\027\017\004\036\f\022\017\b )]TJ -0.034 Tw T* (\007\026\027\027\t\b \017)Tj /Span<>> BDC ( )Tj EMC (\027\026\f\022\024\035\034\022\024 \017\b \023\030\017\n\036\027\036\027\ \017\036 \023\024\r\024\035\017\021 \024\023\021\017\n\017)Tj 0 Tw (-)Tj T* (\017\030\024\r\026\021\034 \021\026\022\021\017\022\031 \r\036\007\036\027\ \017\016 \023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\025\217\217.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 303.3769 188.9979 Tm (\017\034\r\237)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf 0 Tc 0.303 Tw 10 0 0 10 303.3071 164.6418 Tm (\202\027\026\035\017 \f\024\r\030\036\n\036\027\027\t\b \017\f\f\035\036\ \007\024\r\026\027\017\005, \017\f\023\024\035\034\031\033\013\017\b )Tj 0.12 Tw T* (\n\036\021\024\007\t \017\f\022\031\f\f\021\r\036\027\027\024\020\024 \017\ \027\021\036\035\035\036\022\021\026 \007\035\016 \023\030\024\020\027\024\ \017\030\024)Tj 0 Tw (-)Tj 0.102 Tw T* [(\r\026\027\017\016 )0.5(\024\021\007\026\035\036\027\027\t\b )0.6(\030\036\031\035\034\021\026\021\024\r )0.6(\035\036\004\036\027\017\016 )0.5(\002\024\035\034\027\t\b )0.6(\022\024)]TJ 0 Tw (-)Tj 0.022 Tw T* (\035\024\030\036\022\021\026\035\034\027\t\n \030\026\022\024\n \027\026\ )Tj /Span<>> BDC ( )Tj EMC (\024\f\027\024\r\036 \022\035\017\027\017\004\036\f\022\017\b \007\026\027\ \027\t\b. )Tj 0.026 Tw T* [(\210\f\027\024\r\027\024\005 \026\007\026\004\036\005 \017\f\f\035\036\007\ \024\r\026\027\017\016 )0.5(\016\r\035\016\036\021\f\016 \f\030\026\r\027\036\027\017\036 )]TJ 0.334 Tw T* (\030\026\035\017\004\027\t\b \026\035\020\024\030\017\021\n\024\r \017\f\ \022\031\f\f\021\r\036\027\027\024\020\024 \017\027\021\036\035\035\036\022\ \021\026, )Tj 0.12 Tw T* (\017\b \023\030\024\020\027\024\f\021\017\004\036\f\022\024\005 \021\024\ \004\027\024\f\021\017 \017)Tj /Span<>> BDC ( )Tj EMC (\023\024\021\036\027\006\017\026\035\034\027\024\005 \022\035\017)Tj 0 Tw (-)Tj T* (\027\017\004\036\f\022\024\005 \023\030\017\n\036\027\017\n\024\f\021\017\ .)Tj ET 1 0.68 0 0.12 k /GS0 gs q 1 0 0 1 70.8661 738.9961 cm 0 0 m 0 0 l 0 -11.339 l 42.52 -11.339 l 42.52 0 l h f Q BT 0 0 0 0 k /T1_1 1 Tf 9 0 0 9 73.5728 730.0688 Tm (ABSTRACT)Tj 1 0.68 0 0.12 k /T1_4 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\007\003\032)50(\n\n\217\n)-21(\035\030\002)]TJ 53.418 0 Td [(MET)30(A)-41(-)-41.9(ANAL)30(Y)30(SIS)]TJ -53.418 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 2)69(4, \023\0224, 202)23(5)]TJ 43.013 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 2)69(4, \023\0224, 202)23(5)]TJ /T1_5 1 Tf 25 0 0 25 20.7776 56.0378 Tm (126)Tj ET endstream endobj 35 0 obj <> endobj 36 0 obj <> endobj 37 0 obj <> endobj 38 0 obj <> endobj 39 0 obj <> endobj 1536 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1537 0 obj <>/Font<>/ProcSet[/PDF/Text/ImageC]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1538 0 obj <>/Font<>/ProcSet[/PDF/Text/ImageC]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1539 0 obj 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for pr)31(edicting long-term outcomes in patients )]TJ 1.361 -1 Td [(with color)31(ectal cancer \(a\022s)10(y)10(stematic r)31(e)11(vie)11(w and meta-analy)10(sis\))]TJ ET 0 0 0 1 K 1 j 1 J [0 2.997]0 d /GS1 gs q 1 0 0 1 46.0167 275.5411 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 43.0197 275.5411 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q [0 2.997]0 d q 1 0 0 1 46.0167 238.3333 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 43.0197 238.3333 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q BT 0 0 0 1 k /T1_1 1 Tf 10 0 0 10 42.5197 724.8299 Tm (https://doi.org/10.33878/2073-7556-2025-24-4-125-137)Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 0.023 Tw 19 0 0 19 81.3288 695.3259 Tm [(\030\b\017\200\b\b)-10(\026\r\016\215\215\220\207 \021\215\026)11(\016\t\t\016\017)-9.9(\026 \211)-21(\t\004 \222\201\025\202\215\025)21(\213\021\201\025\r\001\215\021\004 )]TJ 1.169 -1.105 Td [(\025\026)11(\211\001\t\016\215\215\220 \201\016\213)21(\200\t\214)21(\026)11(\001\026)11(\025\r \t\016\f\016\215\021\004 \235\025\t\214\215\220 )]TJ -1.31 -1.105 Td [(\017)10(\025\t\025\201\016\017)-9.9(\026)10.9(\001\t\214\215\220\024 \201\001\017)10(\025\024 \(\b\021\b)-10(\026)11(\016\024\001\026\021\f\016\b\017\021\207 \025\235\213\025\201 )]TJ 0 Tw 7.032 -1.105 Td [(\021\022)-23.3(\024\016\026)11(\001\001\215\001\t\021\213\))]TJ 0 0 0 1 k /GS1 gs 14 0 0 14 42.5197 607.822 Tm [(\n\235\211\200\t\001\016\r\001\022)-23.2(\033)124(.\255.)]TJ 8.162 0 0 8.162 135.7907 612.484 Tm (1)Tj 0.023 Tw 14 0 0 14 140.4267 607.822 Tm [(, \034\001\r\t\025\r\001\022)-23.2(\006.\030.)]TJ -0.069 Tc 0.069 Tw 8.162 0 0 8.162 226.7855 612.484 Tm [(1,)-69(2)]TJ 0 Tc 0.023 Tw 14 0 0 14 238.1061 607.822 Tm [(, \031)70(\016\r\025\201\017\004\215\022)-23.2(\032.\031)72(.)]TJ 0 Tw 8.162 0 0 8.162 319.5373 612.484 Tm (1)Tj 0.023 Tw 14 0 0 14 324.1732 607.822 Tm [(, \206\016\t\016\215\214\017\001\004\022)-23.2(\027.\006.)]TJ 0 Tw 8.162 0 0 8.162 417.1399 612.484 Tm (1)Tj 14 0 0 14 421.7758 607.822 Tm (, )Tj -27.09 -1.143 Td [(\007\001\215\200\017\004\215\022)-23.2(\007.\255.)]TJ 8.162 0 0 8.162 130.1906 596.484 Tm (1)Tj 0.023 Tw 14 0 0 14 134.8265 591.822 Tm [(, \031)80(\025\201\211\016\016\r\022)-23.2(\013.\013.)]TJ -0.069 Tc 0.069 Tw 8.162 0 0 8.162 217.0979 596.484 Tm [(1,)-69(2)]TJ 0 Tc 0 Tw 5.83 0 0 5.83 42.5197 577.4827 Tm (1)Tj 0.023 Tw 10 0 0 10 45.8311 574.1527 Tm [(\203\031\206)42(\230 \253\217\007\030\226 \025\215\017)10(\025\t\025\202\021\021 \021\024.\022)-23.3(\217.\217.\022)-23.3(\206\t\025\021\215\001\273 \007\021\215\213\211\201\001\r\001 \033\025\b\ \b\021\021 \(\037)41(\001\020\021\201\b\017)10(\025\016 \020., \211.\022)-23.3(23, \202)62(.\022)-23.3(\007\025\b\017\r\001, 1)212(1)113(5)23(5)35(22, )]TJ 0 Tw -0.331 -1.2 Td (\033\025\b\b\021\004\))Tj ( )Tj 5.83 0 0 5.83 42.5197 553.4827 Tm (2)Tj 0.023 Tw 10 0 0 10 45.8311 550.1527 Tm [(\203\031\206)42(\230 \006\036 \253\032)41(\205\024\016\215\b\017\021\207 \202)10(\025\b\200\211\001\201\b)-9.9(\026\r\016\215\215\220\207 \024\016\211\021\212\021\215\b\017\021\207 \200\ \215\021\r\016\201\b\021\026)11(\016\026\273 \007\021\215\213\211\201\001\r\001 \033\025\b\b\021\021 \(\200\ \t.\022)-23.3(\036\211\016\b\b\017\001\004, )]TJ -0.331 -1.2 Td [(\211.\022)-23.3(5)23(4, \202)62.1(.\022)-23.3(\032)41(\205\024\016\215\214, 6)35(2)23(5023, \033\025\b\b\021\004\))]TJ /T1_1 1 Tf -0.033 Tw 9 0 0 9 90.7087 519.6488 Tm [(\221\204\231\232: )0.5(\034\007\016\020\022\035\003 )0.5(\220\017\017\016\021\035\022\036\020\034\024\035\003 )0.6(\037\027\013\034\033\022\035\006\034\036 )0.6(\022\024\021\023\024\024\035\036\016\020\020\034\013\034 )0.6(\022\020\035\016\027\027\016\021\035\037 )0.5(\b\027\030 )0.5(\f\033\034\013\020\034\031\022\033\034\036\037\020\022\030 )0.5(\034\035\b\037\027\016\020\020\032\002 )]TJ 0.023 Tw 0 -1.111 TD (\033\016\031\023\027\003\035\037\035\034\036 \027\016\005\016\020\022\030\ \025\034\027\003\020\032\002 \021\034\027\034\033\016\021\035\037\027\003\ \020\032\006 \033\037\021\034\006 \(\r\213\213\) \020\037)Tj /Span<>> BDC ( )Tj EMC (\034\024\020\034\036\016 \021\027\022\020\022\005\016\024\021\022\002 \b\ \037\020\020\032\002.)Tj -0.019 Tw T* (\214\205\202\204\213\200\205\231\233 \200)Tj /Span<>> BDC ( )Tj EMC (\214\204\202\240\n\233: \f\033\034\036\016\b\016\020 \024\022\024\035\016\ \006\037\035\022\005\016\024\021\022\004 \f\034\022\024\021 \020\037\023\ \005\020\032\002 \f\023\025\027\022\021\037\007\022\004 \031\037)Tj /Span<>> BDC ( )Tj EMC (2015\2262024)Tj /Span<>> BDC ( )Tj EMC (\013\013. \036)Tj /Span<>> BDC ( )Tj EMC (\025\037\031\037\002 \b\037\020)Tj 0 Tw (-)Tj -0.03 Tw T* (\020\032\002 PubMed, ScienceDirect, MedRxiv, BioRxiv \022)Tj /Span<>> BDC ( )Tj EMC (Google Scholar. \021\027\026\005\016\020\032 \034\033\022\013\022\020\037\ \027\003\020\032\016 \022\024\024\027\016\b\034\036\037\020\022\030, \f\033\ \022\006\016\020\030\036)Tj 0 Tw (-)Tj 0.054 Tw T* (\001\022\016 \006\016\035\034\b\032 \006\037\001\022\020\020\034\013\034\ \034\025\023\005\016\020\022\030 \022)Tj /Span<>> BDC ( )Tj EMC (\013\027\023\025\034\021\034\013\034 \034\025\023\005\016\020\022\030 \022\ \024\021\027\026\005\022\035\016\027\003\020\034 \020\037)Tj /Span<>> BDC ( )Tj EMC (\034\024\020\034\036\016 \021\027\022\020\022\005\016\024\021\022\002 \b\ \037\020\020\032\002 \b\027\030 )Tj 0.015 Tw T* (\f\033\034\013\020\034\031\022\033\034\036\037\020\022\030 \033\016\007\022\ \b\022\036\037 \r\213\213. \200\031)Tj /Span<>> BDC ( )Tj EMC (657106 \036\032\030\036\027\016\020\020\032\002 \f\023\025\027\022\021\037\ \007\022\004 \021\033\022\035\016\033\022\030\006 \036\021\027\026\005\016\ \020\022\030 \024\034\034\035\036\016\035\024\035\036\034\036\037)Tj 0 Tw (-)Tj -0.023 Tw T* [(\027\022 )0.5(43 )0.5(\022\024\024\027\016\b\034\036\037\020\022\030, )0.5(\022\031)]TJ /Span<>> BDC ( )Tj EMC 9.531 0 Td [(\021\034\035\034\033\032\002 )0.6(12 )0.5(\036\034\001\027\022 )0.5(\036)]TJ /Span<>> BDC ( )Tj EMC 8.618 0 Td [(\006\016\035\037\037\020\037\027\022\031. )0.6(\240\007\016\020\022\036\037\027\022\024\003 )0.5(\034\025\235\037\030 )0.5(\f\027\034\235\037\b\003 )0.5(\f\034\b )0.5(ROC-\021\033\022\036\034\004 )0.5(\(AUC\), )]TJ 0.214 Tw -18.149 -1.111 Td (\f\034\021\037\031\037\035\016\027\022 \013\016\035\016\033\034\013\016\020\ \020\034\024\035\022 \(I\262, \251\262, Q-\035\016\024\035\), \020\037\027\ \022\005\022\016 \f\023\025\027\022\021\037\007\022\034\020\020\034\013\034\ \024\006\016\235\016\020\022\030 \022)Tj /Span<>> BDC ( )Tj EMC (\005\023\036\024\035\036\022\035\016\027\003\020\034\024\035\003 )Tj 0.023 Tw 0 -1.111 TD (\033\016\031\023\027\003\035\037\035\034\036. \211\023\036\024\035\036\022\ \035\016\027\003\020\034\024\035\003 \033\016\031\023\027\003\035\037\035\ \034\036 \006\016\035\037\037\020\037\027\022\031\037 \025\032\027\037 \f\ \034\b\035\036\016\033\201\b\016\020\037 \006\016\035\034\b\034\006 leav\ e-one-out.)Tj -0.023 Tw 0 -1.111 TD (\213\204\255\215\231\232\202\205\202\233: \f\034)Tj /Span<>> BDC ( )Tj EMC (\033\016\031\023\027\003\035\037\035\037\006 \f\033\034\036\016\b\016\020\ \020\034\013\034 \037\020\037\027\022\031\037 \025\032\027\034 \023\024\035\ \037\020\034\036\027\016\020\034, \005\035\034 \020\037\022\025\034\027\016\ \016 \005\037\024\035\034 \f\033\022\006\016\020\030\016\006\032\006\022\ )Tj 0.045 Tw T* (\037\027\013\034\033\022\035\006\037\006\022 \025\032\027\022 Random For\ est \(67%\), Support Vector Machine \(51%\) \022)Tj /Span<>> BDC ( )Tj EMC (XGBoost \(37%\). \240\025\235\037\030 \034\025\206\016\b\022\020\246\020\ )Tj 0 Tw (-)Tj T* (\020\037\030 \f\033\034\013\020\034\024\035\022\005\016\024\021\037\030 \ \035\034\005\020\034\024\035\003 \006\034\b\016\027\016\004 \006\037\001\ \022\020\020\034\013\034 \034\025\023\005\016\020\022\030 \036)Tj /Span<>> BDC ( )Tj EMC (\f\033\034\013\020\034\031\022\033\034\036\037\020\022\022 \034\025\235\016\ \004 \036\032\201\022\036\037\016\006\034\024\035\003 \r\213\213 )Tj -0.033 Tw T* (\f\034\021\037\031\037\027\037 \034\005\016\020\003 \002\034\033\034\001\ \022\016 \033\016\031\023\027\003\035\037\035\032)Tj /Span<>> BDC ( )Tj EMC (\227 AUC)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,86 \(95% \n\200: 0,82\2260,89\). \006\016\024\035\016 \024)Tj /Span<>> BDC ( )Tj EMC (\035\016\006, \036\032\030\036\027\016\020\037 \031\020\037\005\022\035\016\ \027\003)Tj 0 Tw (-)Tj 0.023 Tw T* (\020\037\030 \006\016\201\022\024\024\027\016\b\034\036\037\035\016\027\003\ \024\021\037\030 \013\016\035\016\033\034\013\016\020\020\034\024\035\003\ \(I\262)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (97,6%, p)Tj /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (0,001\) \022)Tj /Span<>> BDC ( )Tj EMC (\023\006\016\033\016\020\020\034\016 \f\023\025\027\022\021\037\007\022\034\ \020\020\034\016 \024\006\016\235\016\020\022\016.)Tj 0.026 Tw T* [(\255\205\r\231\234\211\204\217\200\204: \036\032\024\034\021\037\030 \f\033\ \034\013\020\034\024\035\022\005\016\024\021\037\030 \035\034\005\020\034\ \024\035\003 )0.5(\006\034\b\016\027\016\004 )0.5(\200\200 \f\034\b\035\036\016\033\201\b\037\016\035 \022\002 \f\034\035\016\ \020\007\022\037\027 )0.5(\b\027\030 \022\020\035\016\013\033\037)]TJ 0 Tw (-)Tj 0.13 Tw T* (\007\022\022 \036)Tj /Span<>> BDC ( )Tj EMC (\021\027\022\020\022\005\016\024\021\023\026 \f\033\037\021\035\022\021\023\ \f\033\022)Tj /Span<>> BDC ( )Tj EMC (\f\033\034\013\020\034\031\022\033\034\036\037\020\022\022 \033\016\007\022\ \b\022\036\037 \r\213\213. \240\b\020\037\021\034 \024\023\235\016\024\035\ \036\016\020\020\037\030 \013\016\035\016\033\034\013\016\020\020\034\024\ \035\003 )Tj 0.177 Tw T* (\006\016\201\b\023 \022\024\024\027\016\b\034\036\037\020\022\030\006\022\ \034\013\033\037\020\022\005\022\036\037\016\035 \036\034\031\006\034\201\ \020\034\024\035\003 \f\033\030\006\034\013\034 \024\033\037\036\020\016\ \020\022\030 \220\017\017\016\021\035\022\036\020\034\024\035\022 \033\037\ \031\027\022\005\020\032\002 \037\027\013\034)Tj 0 Tw (-)Tj 0.023 Tw 0 -1.111 TD (\033\022\035\006\034\036 \022)Tj /Span<>> BDC ( )Tj EMC (\035\033\016\025\023\016\035 \034\024\035\034\033\034\201\020\034\024\035\ \022 \036)Tj /Span<>> BDC ( )Tj EMC (\022\020\035\016\033\f\033\016\035\037\007\022\022 \033\016\031\023\027\003\ \035\037\035\034\036.)Tj /T1_2 1 Tf 0.01 Tc 0.124 Tw 8 0 0 8 42.5596 334.3796 Tm [(\037\033\016\r\030\025\f\030)5( \026\033\036\025\021:)]TJ /T1_1 1 Tf 0 Tc 0.129 Tw 8.599 0 Td ( \021\034\027\034\033\016\021\035\037\027\003\020\032\004 \033\037\021, \ \022\024\021\023\024\024\035\036\016\020\020\032\004 \022\020\035\016\027\ \027\016\021\035, \006\037\001\022\020\020\034\016 \034\025\023\005\016\020\ \022\016, \f\033\034\013\020\034\031\022\033\034\036\037\020\022\016 \036\ \032\201\022\036\037\016\006\034\024\035\022, \f\033\034\013\020\034)Tj 0 Tw (-)Tj 0.023 Tw -8.604 -1.2 Td (\024\035\022\005\016\024\021\037\030 \006\034\b\016\027\003)Tj /T1_2 1 Tf 0.01 Tc 0.018 Tw 0.005 -1.909 Td [(\037\036\035\034\033\032\037\031)5( \032\035\031\030\027\030\026\036\025:)]TJ /T1_1 1 Tf 0 Tc 0.023 Tw 10.401 0 Td ( \037\036\035\034\033\032 \031\037\030\036\027\030\026\035 \034\025 \034\ \035\024\023\035\024\035\036\022\022 \021\034\020\017\027\022\021\035\037\ \022\020\035\016\033\016\024\034\036)Tj /T1_2 1 Tf 0.017 Tc -0.017 Tw -10.401 -1.909 Td (\034\032\035\021\035\026\032\027\036\025\021\035\032\030:)Tj /T1_1 1 Tf 0.007 Tc 0.35 Tw 8.765 0 Td [( \200\024\024\027\016\b\034\036\037\020\022\016 \024\f\034\020\024\022\033\ \034\036\037\020\034 \205\020\037\027\022\035\022\005\016\024\021\022\006\ \221\016\020\035\033\034\006 \f\033\037\036\022\035\016\027\003\024\035\ \036\037 \213\034\024\024\022\004\024\021\034\004 \216\016\b\016\033\037\ \007\022\022 \(\024\034\013\027\037\001\016\020\022\016)7( )]TJ 0 Tc 0.023 Tw -8.77 -1.2 Td (\230)Tj /Span<>> BDC ( )Tj EMC (70-2024-000121 \034\035 29.03.2024. IGK 000000D730324P540002\))Tj /T1_2 1 Tf 0.033 Tc 0.126 Tw 0.005 -2.617 Td [(\024\033\023)4.7( \022\032\031\032\027\036\025\021\035\032\023:)]TJ /T1_3 1 Tf 0.023 Tc 0.131 Tw 9.298 0 Td ( \202\002\007\031\035\026\036\r\026)Tj /Span<>> BDC ( )Tj EMC (\217.\221. \215\026\r\035\024\r\026)Tj /Span<>> BDC ( )Tj EMC (\200.\236., \206\036\r\024\030\022\016\027)Tj /Span<>> BDC ( )Tj EMC (\230.\206., \207\036\035\036\027\034\022\026\016)Tj /Span<>> BDC ( )Tj EMC (\233.\200., \204\026\027\031\022\016\027)Tj /Span<>> BDC ( )Tj EMC (\204.\221., \206\024\030\007\036\036\r)Tj /Span<>> BDC ( )Tj EMC [(\224.\224. \236\f\022\031\f\f\021\r\036\027\027\t\005)23( )]TJ -0.027 Tw -9.303 -1.2 Td (\017\027\021\036\035\035\036\022\021 \007\035\016 \023\030\024\020\027\024\ \017\030\024\r\026\027\017\016 \024\021\007\026\035\036\027\027\t\b \030\ \036\031\035\034\021\026\021\024\r \035\036\004\036\027\017\016 \002\024\ \035\034\027\t\b \022\024\035\024\030\036\022\021\026\035\034\027\t\n \030\ \026\022\024\n \(\f\017\f\021\036\n\026\021\017\004\036\f\022\017\005 \024\ \002\024\030 \017)Tj /Span<>> BDC ( )Tj EMC (\n\036\021\026)Tj 0 Tc 0 Tw (-)Tj 0.023 Tc -0.023 Tw 0 -1.2 TD (\026\027\026\035\017\). )Tj /T1_1 1 Tf 3.989 0 Td (\r\034\027\034\f\033\034\021\035\034\027\034\013\022\030.)Tj /T1_3 1 Tf 0.024 Tw ( 2025; \021.)Tj /Span<>> BDC ( )Tj EMC (24, \223)Tj /Span<>> BDC ( )Tj EMC 14.78 0 Td (4, \f.)Tj /Span<>> BDC ( )Tj EMC (125\226137. https://doi.org/10.33878/2073-7556-2025-24-4-125-137)Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 0 Tc 0.023 Tw 18 0 0 18 108.5447 212.164 Tm [(Ar)-20(tif)-20.9(icial intelligence for pr)31(edicting long-term )]TJ 0.413 -1.167 Td [(outcomes in patients with color)31.1(ectal cancer )]TJ 0.595 -1.167 Td [(\(a\022)-23.3(s)10(y)10(stematic r)31(e)11(vie)11(w and meta-analy)10.1(sis\))]TJ 0 0 0 1 k /GS1 gs 14 0 0 14 42.5197 145.66 Tm [(Rukiy)21(at\022)-23.2(Sh.\022)-23.3(Abdulae)11(v)10(a\271, V)31(aleria\022)-23.2(I.\022)-23.3(P)20(avlov)10(a)]TJ -0.069 Tc 0.069 Tw 8.162 0 0 8.162 281.7833 150.322 Tm [(1,)-69(2)]TJ 0 Tc 0.023 Tw 14 0 0 14 293.1039 145.66 Tm [(, Tigr)21(an\022)-23.2(G.\022)-23.3(Ge)11(v)10(orky)21(an\271, )]TJ 0 Tw -17.899 -1.143 Td [(Y)50(ana\022)-23.3(V)62(.\022)-23.2(Belenkay)21(a)]TJ 8.162 0 0 8.162 147.4844 134.322 Tm (1)Tj 0.023 Tw 14 0 0 14 152.1204 129.66 Tm [(, Mariam\022)-23.2(Sh.\022)-23.3(Manuky)21.1(an\271, Ser)31(gey\022)-23.3(S.\022)-23.2(Gor)31(dee)11(v)]TJ -0.069 Tc 0.069 Tw 8.162 0 0 8.162 408.4535 134.322 Tm [(1,)-69(2)]TJ 0 Tc 0.023 Tw 10 0 0 10 42.5197 111.9908 Tm [(\271N.N.\022)-23.2(Blokhin National Medical Resear)31(ch Center of\022)-23.3(Oncology \(K)41(ashir)20(sk)11(oy)10(e sh)11(osse, 23, Moscow)22.1(, 1)212(1)113(5)23(5)35(22, )]TJ 0 Tw 0 -1.2 TD (Russia\))Tj ( )Tj 0.023 Tw 0 -1.2 TD [(\262T)20(y)10(umen State Medical Univ)12.1(er)20(sit)-20(y \(Odesskay)21(a Str)31.1(eet, 5)23(4, T)20(y)10(umen, 6)34.9(2)23.1(5023, Russia\))]TJ ET 1 0.68 0 0.12 k /GS0 gs q 1 0 0 1 42.5197 528.1533 cm 0 0 m 0 0 l 0 -11.339 l 42.52 -11.339 l 42.52 0 l h f Q BT 0 0 0 0 k /T1_2 1 Tf 0 Tw 9 0 0 9 47.6607 519.226 Tm (\027\030\013\016\n\030)Tj ET q 0 0 566.929 793.701 re W n BT 1 0.68 0 0.12 k /T1_4 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 42.5895 837.3533 Tm [(\213\207)-21(\r)41(\037\037\t\037)-19.9(\b\006\215)]TJ /T1_0 1 Tf 0 -1.605 TD [(MET)30(A)5(\244)5(ANAL)30(Y)30(SIS)]TJ ET Q BT 1 0.68 0 0.12 k /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\007\003\032)50(\n\n\217\n)-21(\035\030\002)]TJ 53.418 0 Td [(MET)30(A)-41(-)-41.9(ANAL)30(Y)30(SIS)]TJ /T1_5 1 Tf 25 0 0 25 505.4397 56.0378 Tm (125)Tj ET q 0 g 0 G 0 j 0 J /Fm1 Do Q 0 0 0 0 k 368.504 725.67 59.155 11.338 re f /PlacedPDF /MC0 BDC q 369.135 736.808 m 368.896 736.808 368.703 736.616 368.703 736.376 c 368.703 736.376 l 368.703 726.285 l 368.703 726.045 368.896 725.853 369.135 725.853 c 369.135 725.853 l 427.035 725.853 l 427.273 725.853 427.469 726.045 427.469 726.285 c 427.469 726.285 l 427.469 736.376 l 427.469 736.616 427.273 736.808 427.035 736.808 c 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)Tj EMC [(D)13.8(z)9.1(h)5.9(an)4.8(t)4.3(u)5.6(k)6.3(h)5.8(an)2.9(ov)11.8(a)]TJ /T1_0 1 Tf 0 Tc 0 Tw -13.043 -1.218 Td [(W)3.1(r)-48(i)-6(t)-37.4(i)7.1(n)-1.9(g o)-2.2(f)]TJ /Span<>> BDC ( )Tj EMC [(t)-16.7(h)-5.3(e t)-15.2(e)-23.9(x)-36(t)-20(:)]TJ /T1_1 1 Tf 0.001 Tc -0.001 Tw [( A)12.6(y)4.8(u)7.4(b)3.2(k)6.4(h)5.8(an)]TJ /Span<>> BDC 11.993 0 Td ( )Tj EMC [(I)3.4(.)]TJ /Span<>> BDC 0.864 0 Td ( )Tj EMC [(V)26.9(ag)1.4(ap)-3.9(ov)]TJ /T1_0 1 Tf 0.006 Tc -0.006 Tw -12.857 -1.218 Td [(E)11.6(dit)-31.4(i)13.1(n)4.1(g)15(:)]TJ /T1_1 1 Tf 0 Tc 0.667 Tw 3.238 0 Td [( Y)33.7(u)6.1(r)-40.2(y)]TJ /Span<>> BDC ( )Tj EMC [(G)-1.4(.)]TJ /Span<>> BDC ( )Tj EMC [(S)16.4(t)2.3(ar)-2.5(k)12.9(o)-0.6(v)33.6(, A)11.6(y)3.8(u)6.4(b)2.2(k)5.3(h)4.8(a)-0.8(n)]TJ /Span<>> BDC ( )Tj EMC [(I)2.4(.)]TJ /Span<>> BDC ( )Tj EMC [(V)25.9(a)-0.8(ga)-0.8(p)-4.9(o)-0.6(v)33.6(, )]TJ -0.005 Tc 0.005 Tw -3.238 -1.218 Td [(S)0.6(e)-13.7(d)-3.1(a)]TJ /Span<>> BDC 1.873 0 Td ( )Tj EMC [(V)48.1(.)]TJ /Span<>> BDC 0.955 0 Td ( )Tj EMC [(D)7.8(z)3.1(ha)-5.8(n)-1.2(t)-1.7(ukha)-5.8(n)-3.1(o)-5.6(v)5.8(a)]TJ /T1_2 1 Tf 0 Tc 0.023 Tw -2.828 -2.436 Td (\255\026\036\031\036\025\034\226 \017\223 \032\026\020\017\022\032\225 \(\ ORCID\))Tj /T1_0 1 Tf 0.104 Tw 0 -1.218 TD (\224\021\026\030\022\024\r \222\030\017\005 \206\036\027\027\026\007\034\ \036\r\017\004)Tj /Span<>> BDC ( )Tj EMC (\227 \004\035\036\027-\022\024\030\030. \217\202\203, \023\030\024)Tj 0 Tw (-)Tj 0.661 Tw T* (\235\036\f\f\024\030, \007.\n.\027., \026\r\036\007\031\033\013\017\005\ \b\017\030\031\030\020\017\004\036\f\022\017\n \220\027)Tj 0 Tw (-)Tj 0.53 Tw T* [(\007\024\f\022\024\023\017\004\036\f\022\017\n \024\021\007\036\035\036\027\ \017\036\n )0.5(\205\206\207\211 \253\203\204\236\037 \b\017\030\031\030)]TJ 0 Tw (-)Tj 0.555 Tw T* (\020\017\017 \017\n. \202.\200. \200\017\001\027\036\r\f\022\024\020\024\ \273 \204\017\027\007\030\026\r\026 \217\024\f\f\017\017; )Tj 0 Tw T* (ORCID)Tj /Span<>> BDC ( )Tj EMC (0000-0003-4722-3466)Tj 0.255 Tw 23.244 23.138 Td (\200\026\020\026\023\024\r \202\033\002\b\026\027 \236\007\030\017\f\024\ \r\017\004)Tj /Span<>> BDC ( )Tj EMC (\227 \022.\n.\027., \r\030\026\004-\b\017\030\031\030\020 )Tj 0.311 Tw T* (\b\017\030\031\030\020\017\004\036\f\022\024\020\024 \220\027\007\024\f\022\ \024\023\017\004\036\f\022\024\020\024 \024\021\007\036\035\036\027\017\016\ \205\206\207\211 )Tj 0.121 Tw T* (\253\203\204\236\037 \b\017\030\031\030\020\017\017 \017\n. \202.\200. \200\ \017\001\027\036\r\f\022\024\020\024\273 \204\017\027\007\030\026\r\026\ )Tj 0 Tw T* (\217\024\f\f\017\017; ORCID)Tj /Span<>> BDC ( )Tj EMC (0000-0003-0773-0498)Tj 0.907 Tw T* (\003\026\n\024\035\024\007\004\017\022\024\r \217\024\007\017\024\027 \212\ \n\017\021\030\017\036\r\017\004)Tj /Span<>> BDC ( )Tj EMC (\227 \022.\n.\027., )Tj 0.524 Tw T* (\f\021\026\030\001\017\005 \027\026\031\004\027\t\005 \f\024\021\030\031\ \007\027\017\022 \b\017\030\031\030\020\017\004\036\f\022\024\020\024 \220\ \027)Tj 0 Tw (-)Tj 0.601 Tw 0 -1.218 TD (\007\024\f\022\024\023\017\004\036\f\022\024\020\024 \024\021\007\036\035\ \036\027\017\016 \205\206\207\211 \253\203\204\236\037 \b\017\030\031\030\ )Tj 0 Tw (-)Tj 0.555 Tw 0 -1.218 TD (\020\017\017 \017\n. \202.\200.)Tj /Span<>> BDC ( )Tj EMC (\200\017\001\027\036\r\f\022\024\020\024\273 \204\017\027\007\030\026\r\ \026 \217\024\f\f\017\017; )Tj 0 Tw T* (ORCID)Tj /Span<>> BDC ( )Tj EMC (0000-0003-2515-9942)Tj 0.501 Tw T* (\212\032\026\027\021\031\b\026\027\024\r\026 \224\036\007\026 \200\017\f\ \026\007\017\036\r\027\026)Tj /Span<>> BDC ( )Tj EMC (\227 \022.\n.\027., \f\021\026\030)Tj 0 Tw (-)Tj 0.721 Tw T* (\001\017\005 \027\026\031\004\027\t\005 \f\024\021\030\031\007\027\017\022\ \b\017\030\031\030\020\017\004\036\f\022\024\020\024 \220\027\007\024)Tj 0 Tw (-)Tj 0.85 Tw T* [(\f\022\024\023\017\004\036\f\022\024\020\024 \024\021\007\036\035\036\027\ \017\016 )0.5(\205\206\207\211 \253\203\204\236\037 \b\017\030\031\030)]TJ 0 Tw (-)Tj 0.555 Tw 0 -1.218 TD (\020\017\017 \017\n. \202.\200.)Tj /Span<>> BDC ( )Tj EMC (\200\017\001\027\036\r\f\022\024\020\024\273 \204\017\027\007\030\026\r\ \026 \217\024\f\f\017\017; )Tj 0 Tw 0 -1.218 TD (ORCID)Tj /Span<>> BDC ( )Tj EMC (0000-0002-8657-8609)Tj /T1_2 1 Tf 0.023 Tw 0 -2.436 TD (INFORMATION ABOUT THE)Tj /Span<>> BDC ( )Tj EMC (AUTHORS \(ORCID\))Tj /T1_0 1 Tf 0 Tw 0 -1.218 TD [(Y)35(ur)-24(y G. S)15.1(t)15(ar)-24(kov)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0003-4722-3466)Tj T* [(A)15(yubkhan I. V)25.1(a)-17(gapov)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0003-0773-0498)Tj T* [(R)11(odion D. Z)10(amol)30.1(odchikov)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0003-2515-9942)Tj T* [(Sed)42(a V. Dzhantukhanov)-14.9(a)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0002-8657-8609)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 70.936 459.64 Tm [(\r\031\024\034\033)48(\026)45(\024)-10(\223\033)48(\026)]TJ 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0 Tc 0.174 Tw 8 0 0 8 70.8661 446.8054 Tm (1.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(P)40(a)15(tel)]TJ /Span<>> BDC ( )Tj EMC [(A, P)40(a)15(t)-12.9(hak)]TJ /Span<>> BDC ( )Tj EMC [(R, Deshp)32(ande)]TJ /Span<>> BDC ( )Tj EMC [(V, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. R)-10(adiofr)-23.9(equency abl)-16(a)15(t)-32(ion )]TJ 0.066 Tw -1.296 -1.25 Td [(using )0.5(BarRx )0.5(for )0.5(t)-13(he)]TJ /Span<>> BDC ( )Tj EMC 8.175 0 Td [(end)-16(oscopic )0.5(tr)-24(ea)15(tment )0.5(of)]TJ /Span<>> BDC ( )Tj EMC [(r)-32.9(adia)15(t)-32(ion )0.5(p)25(r)-32(o)-16(c)-16(t)17(op)32(a)15(t)-13(hy: )]TJ 0.279 Tw -8.175 -1.25 Td (a)Tj /Span<>> BDC ( )Tj EMC [(ser)-36.9(ies of)]TJ /Span<>> BDC ( )Tj EMC [(t)-13(hr)-23.9(ee cases. )]TJ /T1_1 1 Tf (Clin Exp Gastroenterol)Tj /T1_0 1 Tf (. 2014;7:453\226460. )Tj 0.023 Tw 0 -1.25 TD [(P)20(ubl)-31(ished 2014 Dec 8. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.2147/CEG.S66534)Tj 0 0 0 1 k /GS1 gs -0.018 Tw T* (2.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (\221\036\035\t\020\017\027)Tj /Span<>> BDC ( )Tj EMC [(\222.\202., )0.5(\203\036\004\031\001\022\017\027)]TJ /Span<>> BDC ( )Tj EMC [(\204.\236., )0.5(\217\t\002\026\022\024\r)]TJ /Span<>> BDC ( )Tj EMC [(\213.\206. )0.5(\210\023\031\b\024\035\017 \026\027\026\035\034\027\024\020\024 )]TJ 0.032 Tw -1.296 -1.25 Td (\022\026\027\026\035\026 \017)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\017\026\027\026\035\034\027\024\005 \022\024\032\017: \215\030\ \026\022\021\017\004\036\f\022\024\036 \030\031\022\024\r\024\007\f\021\r\ \024 \007\035\016 \r\030\026)Tj 0 Tw (-)Tj T* (\004\036\005. )Tj /T1_1 1 Tf 0.023 Tw 2.007 0 Td (\t\033\037\021\035\022\005\016\024\021\037\030 \006\016\b\022\007\022\020\ \037)Tj /T1_0 1 Tf (. 2011; 128 \f.)Tj 0.015 Tc 0.532 Tw -2.007 -1.25 Td [(3)0.5(.)]TJ /Span<>> BDC ( )Tj EMC 1.34 0 Td [(\206)0.5(\030\017)0.5(\001)0.5(\017\027)0.5(\026)]TJ /Span<>> BDC ( )Tj EMC [(\213)0.5(.)0.5(\202.)0.5(,)0.5( \221)0.5(\017)0.5(\001\017)0.5(\027)]TJ /Span<>> BDC 10.271 0 Td ( )Tj EMC [(\025.)0.5(\200)0.5(.,)0.5( \203\036)0.5(\007)0.5(\024\035)0.5(\031)0.5(\032\022)0.5(\024)]TJ /Span<>> BDC 8.257 0 Td ( )Tj EMC [(\236.)0.5(\222)0.5(.,)0.5( \017)]TJ /Span<>> BDC ( )Tj EMC [(\f)0.5(\024\026)0.5(\r)0.5(\021.)15( )]TJ 0.019 Tc 0.684 Tw -19.867 -1.25 Td [(\225\027\007\024\f\022\024\023\017\004\036\f\022\017\036 \n\036\021\024\007\ \t \035\036\004\036\027\017\016 \b\030\024\027\017\004\036\f\022\024\020\ \024 \035\031\004\036\r\024\020\024)19( )]TJ 0.005 Tc -0.005 Tw T* (\023\030\024\022\021\017\021\026. )Tj /T1_1 1 Tf 0.349 Tw 4.631 0 Td (\202\037\031\034\036\037\030 \002\022\033\023\033\013\022\030 \022)Tj /Span<>> BDC ( )Tj EMC (\034\020\021\034\027\034\013\022\030.)Tj /T1_0 1 Tf [( 2020;10\(3-4\):65\22672.)5.1( )]TJ 0 Tc 0 Tw -4.631 -1.25 Td [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.17650/2686-9594-2020-10-3-4-65-72)Tj 0 0 0 1 k /GS1 gs 0.091 Tw -1.847 -1.25 Td (4.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Ir)-32(v)-16(ing)]TJ /Span<>> BDC ( )Tj EMC (F, Chanin)Tj /Span<>> BDC ( )Tj EMC [(W, McEl)16(w)-12(ain)]TJ /Span<>> BDC ( )Tj EMC [(J. Mana)-17(gement of)]TJ /Span<>> BDC ( )Tj EMC [(ad)-17(v)-15(anced r)-33(adia)]TJ 0 Tw (-)Tj 0.023 Tw -1.296 -1.25 Td [(t)-32(ion p)25(r)-32(o)-16(c)-15.9(t)-32(i)-24(t)-32(is. )]TJ /T1_1 1 Tf (Ann Surg)Tj /T1_0 1 Tf (. 1959;150:890\2264.)Tj 0.021 Tw T* (5.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(T)40(a)-17(gk)-17(al)-31(idis)]TJ /Span<>> BDC ( )Tj EMC [(PP, T)45(jandr)-33(a)]TJ /Span<>> BDC ( )Tj EMC [(JJ. Chr)-32(onic r)-33(adia)15(t)-32(ion p)25(r)-32(o)-16(c)-16(t)-31.9(i)-24(t)-32(is. )]TJ /T1_1 1 Tf [(A)53(NZ J Surg)]TJ /T1_0 1 Tf 0 Tw (. )Tj 0.023 Tw -1.296 -1.25 Td [(2001 Ap)25(r;71\(4\):230\2267. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1046/j.1440-1622.2001.02081.x)Tj 0 0 0 1 k /GS1 gs 0.081 Tw T* (6.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Q)-16(uastler)]TJ /Span<>> BDC ( )Tj EMC [(H. Cell r)-24(enew)-12(al and a)-17(cute r)-33(adia)15(t)-32(ion d)42(ama)-16.9(ge. )]TJ /T1_1 1 Tf 0 Tw [(R)20.1(adiology)]TJ /T1_0 1 Tf (. )Tj 0.023 Tw -1.296 -1.25 Td [(1959;73:161\2265. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1148/73.2.161)Tj 0 0 0 1 k /GS1 gs -0.015 Tw 29.055 20 Td (7.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(S)-16(had)42(ad)]TJ /Span<>> BDC ( )Tj EMC 3.099 0 Td [(AK, )0.6(Sull)-31(i)-16(v)-15(an)]TJ /Span<>> BDC ( )Tj EMC 4.958 0 Td [(F)-10(J, )0.6(Mar)-22(t)-32(in)]TJ /Span<>> BDC ( )Tj EMC 4.156 0 Td [(JD, )0.5(e)-11.9(t)]TJ /Span<>> BDC ( )Tj EMC 2.458 0 Td [(al. )0.6(Gastr)-32(ointest)-32(inal )0.6(r)-33(adia)15(t)-32(ion )]TJ -0.02 Tw -15.967 -1.25 Td [(injur)-23.9(y: sym)10(pt)17(oms, r)-37(isk f)16(a)-16.9(c)-16(t)17(or)-10(s and mechanis)26(ms. )]TJ /T1_1 1 Tf [(W)29(orld J Gastroenterol.)]TJ /T1_0 1 Tf 0 Tw ( )Tj 0.023 Tw T* [(2013;19\(2\):185\22698. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.3748/wjg.v19.i2.185)Tj 0 0 0 1 k /GS1 gs 0.336 Tw T* (8.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(R)11(ober)-22(tson)]TJ /Span<>> BDC ( )Tj EMC [(I, L)35(eung)]TJ /Span<>> BDC ( )Tj EMC (E, Hughes)Tj /Span<>> BDC ( )Tj EMC [(D, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. P)35(r)-31.9(ospec)-16(t)-32(i)-16(ve anal)35(y)-12.9(sis )]TJ 0.209 Tw -1.296 -1.25 Td (of)Tj /Span<>> BDC ( )Tj EMC [(st)17(oma-r)-24(el)-15.9(a)15(ted com)10(pl)-31(ica)15(t)-32(ions. )]TJ /T1_1 1 Tf [(Colorectal )0.5(Dis.)]TJ /T1_0 1 Tf ( 2005;7\(3\):279\22685. )Tj 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1111/j.1463-1318.2005.00785.x)Tj 0 0 0 1 k /GS1 gs 0.211 Tw -1.847 -1.25 Td (9.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(L)35(enz)]TJ /Span<>> BDC ( )Tj EMC [(L, R)11(ohr)]TJ /Span<>> BDC ( )Tj EMC [(R, Nak)-17(ao)]TJ /Span<>> BDC ( )Tj EMC [(F, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Chr)-32(onic r)-33(adia)15(t)-32(ion p)25(r)-32(o)-16(c)-16(t)17(op)32(a)15(t)-12.9(hy: )]TJ -0.034 Tw -1.296 -1.25 Td (A)Tj /Span<>> BDC ( )Tj EMC [(p)25(r)-33(a)-17(c)-16(t)-32(ical r)-24(ev)-16(iew of)]TJ /Span<>> BDC ( )Tj EMC [(end)-16(oscopic tr)-23.9(ea)15(tment. )]TJ /T1_1 1 Tf [(W)29(orld J Gastrointest Surg.)]TJ /T1_0 1 Tf 0 Tw ( )Tj 0.023 Tw T* [(2016;8\(2\):151\22660. d)-15.9(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.4240/wjgs.v8.i2.151)Tj 0 0 0 1 k /GS1 gs 0.013 Tc 0.472 Tw T* (10.)Tj /Span<>> BDC ( )Tj EMC 1.847 0 Td (Zhou)Tj /Span<>> BDC ( )Tj EMC [(C, A)15.2(dler)]TJ /Span<>> BDC ( )Tj EMC [(DC, Beck)10.2(er)]TJ /Span<>> BDC ( )Tj EMC [(L, e)-11.8(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Ef)-55.8(fec)-15.9(t)-31.8(i)-15.8(ve tr)-23.8(ea)15.2(tment)13( )]TJ 0.018 Tc 0.636 Tw -1.847 -1.25 Td [(o)0.5(f)]TJ /Span<>> BDC 0.85 0 Td ( )Tj EMC [(c)0.5(h)0.5(r)-31.5(o)0.5(n)0.5(i)0.5(c)0.5( r)-32.5(a)0.5(d)0.5(i)0.5(a)15.5(t)-31.6(i)0.6(o)0.5(n p)25.5(r)-31.5(o)-15.5(c)-15.5(t)-31.5(i)-23.5(t)-31.4(i)0.5(s u)0.5(si)0.5(n)0.5(g)0.5( r)-32.5(a)0.5(d)0.5(i)0.5(o)0.5(f)0.5(r)-23.5(e)0.5(q)0.5(u)0.5(e)0.5(n)0.5(c)0.5(y)0.5( a)0.5(b)0.5(l)-15.5(a)]TJ 0 Tc 0 Tw 26.436 0 Td (-)Tj 0.017 Tc -0.017 Tw -27.286 -1.25 Td [(t)-31.5(i)0.6(o)0.5(n)0.5(.)0.5( )]TJ /T1_1 1 Tf 0.6 Tw 2.91 0 Td [(T)0.5(h)0.5(e)0.6(r)0.5(a)0.5(p)0.5( A)0.6(d)0.5(v)0.5( G)0.6(a)0.5(s)0.5(t)0.5(r)0.5(o)0.6(e)0.5(n)0.5(t)0.5(e)0.5(r)0.6(o)0.5(l)]TJ /T1_0 1 Tf 11.387 0 Td [(.)0.5( 2)0.6(0)0.5(0)0.5(9)0.5( J)0.5(a)0.6(n)0.5( 1)0.5(;)0.5(2)0.5(\()0.6(3)0.5(\))0.5(:)0.5(1)0.5(4)0.5(9)0.5(\226)0.6(1)0.5(5)0.5(6)0.5(.)17( )]TJ 0 Tc 0 Tw -14.298 -1.25 Td [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1177/1756283x08103341)Tj 0 0 0 1 k /GS1 gs -0.013 Tw -1.847 -1.25 Td (11.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Rust)15(a)-17(gi)]TJ /Span<>> BDC ( )Tj EMC [(T, Cor)-23.9(be)-12(t)-30(t)]TJ /Span<>> BDC ( )Tj EMC (FS, Mashimo)Tj /Span<>> BDC ( )Tj EMC [(H. T)50(r)-23.9(ea)15(tment of)]TJ /Span<>> BDC ( )Tj EMC [(chr)-32(onic r)-32.9(adia)15(t)-32(ion )]TJ 0.053 Tw -1.796 -1.25 Td [(p)25(r)-32(o)-16(c)-16(t)17(op)32(a)15(t)-12.9(hy wi)-24(t)-13(h r)-33(adiofr)-23.9(equency abl)-16(a)15(t)-32(ion \(wi)-23.9(t)-13(h v)-16(ideo\). )]TJ /T1_1 1 Tf 0 Tw (Gastrointest )Tj T* (Endosc)Tj /T1_0 1 Tf 0.023 Tw [(. 2015 F)10(eb;81\(2\):428\22636. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1016/j.gie.2014.04.038)Tj /T1_3 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 70.936 255.8322 Tm (REFERENCES)Tj 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0 Tc 0.174 Tw 8 0 0 8 70.8661 242.9976 Tm (1.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(P)40(a)15(tel)]TJ /Span<>> BDC ( )Tj EMC [(A, P)40(a)15(t)-12.9(hak)]TJ /Span<>> BDC ( )Tj EMC [(R, Deshp)32(ande)]TJ /Span<>> BDC ( )Tj EMC [(V, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. R)-10(adiofr)-23.9(equency abl)-16(a)15(t)-32(ion )]TJ 0.066 Tw -1.296 -1.25 Td [(using )0.5(BarRx )0.5(for )0.5(t)-13(he)]TJ /Span<>> BDC ( )Tj EMC 8.175 0 Td [(end)-16(oscopic )0.5(tr)-24(ea)15(tment )0.5(of)]TJ /Span<>> BDC ( )Tj EMC [(r)-32.9(adia)15(t)-32(ion )0.5(p)25(r)-32(o)-16(c)-16(t)17(op)32(a)15(t)-13(hy: )]TJ 0.279 Tw -8.175 -1.25 Td (a)Tj /Span<>> BDC ( )Tj EMC [(ser)-36.9(ies of)]TJ /Span<>> BDC ( )Tj EMC [(t)-13(hr)-23.9(ee cases. )]TJ /T1_1 1 Tf (Clin Exp Gastroenterol)Tj /T1_0 1 Tf (. 2014;7:453\226460. )Tj 0.023 Tw T* [(P)20(ubl)-31(ished 2014 Dec 8. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.2147/CEG.S66534)Tj 0 0 0 1 k /GS1 gs 0.089 Tw T* (2.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(S)-16(hel)35(ygin Y.A., Nechushk)-15.9(in)]TJ /Span<>> BDC ( )Tj EMC [(M.I., R)-20(ybakov)]TJ /Span<>> BDC ( )Tj EMC [(E.G. T)60(umor)-9.9(s of)]TJ /Span<>> BDC ( )Tj EMC [(t)-13(he anal )]TJ -0.005 Tw -1.296 -1.25 Td [(canal and per)-37(ianal sk)-16(in: A)]TJ /Span<>> BDC ( )Tj EMC [(p)25(r)-33(a)-17(c)-16(t)-32(ical guide for d)-16(o)-16(c)-16(t)17(or)-9.9(s. )]TJ /T1_1 1 Tf (Practical medi)Tj 0 Tw (-)Tj T* (cine.)Tj /T1_0 1 Tf 0.023 Tw ( 2011; 128 p. \(in Russ.\).)Tj 0.168 Tw T* (3.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(G)20(r)-37(ishina)]TJ /Span<>> BDC ( )Tj EMC [(E.A., S)-16(hishin)]TJ /Span<>> BDC ( )Tj EMC [(K.V., Ned)-16(ol)35(uzhko)]TJ /Span<>> BDC ( )Tj EMC [(I.Y)35(u., e)-11.9(t)]TJ /Span<>> BDC ( )Tj EMC [(al. End)-15.9(oscopic )]TJ 0.011 Tc 0.39 Tw -1.296 -1.25 Td [(t)0.5(r)-23.4(e)0.5(a)15.5(t)0.6(m)0.5(e)0.5(n)0.5(t)0.6( f)0.5(o)0.5(r)0.6( c)0.5(h)0.5(r)-31.4(o)0.5(n)0.5(i)0.6(c)0.5( r)-32.5(a)0.6(d)0.5(i)0.5(a)15.5(t)-31.4(i)0.5(o)0.5(n)0.6( p)25.5(r)-31.5(o)-15.4(c)-15.5(t)-31.5(i)-23.4(t)-31.5(i)0.5(s)0.5(.)0.6( P)30.5(e)0.6(l)30.5(v)-15.5(i)0.6(c)0.5( S)0.5(u)0.6(r)-31.5(g)0.5(e)0.5(r)-23.4(y)0.5( a)0.5(n)0.5(d)11( )]TJ 0.001 Tc 0.349 Tw T* [(Oncol)30.1(o)-16(g)16(y. 2020;10\(3-4\):65\22672. \(in Russ.\). d)-15.9(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs -0.001 Tw (10.17650/2686-)Tj 0 Tc 0 Tw T* (9594-2020-10-3-4-65-72)Tj 0 0 0 1 k /GS1 gs 0.091 Tw T* (4.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Ir)-32(v)-16(ing)]TJ /Span<>> BDC ( )Tj EMC (F, Chanin)Tj /Span<>> BDC ( )Tj EMC [(W, McEl)16(w)-12(ain)]TJ /Span<>> BDC ( )Tj EMC [(J. Mana)-17(gement of)]TJ /Span<>> BDC ( )Tj EMC [(ad)-17(v)-15(anced r)-33(adia)]TJ 0 Tw (-)Tj 0.023 Tw -1.296 -1.25 Td [(t)-32(ion p)25(r)-32(o)-16(c)-15.9(t)-32(i)-24(t)-32(is. )]TJ /T1_1 1 Tf (Ann Surg)Tj /T1_0 1 Tf (. 1959;150:890\2264.)Tj 0.021 Tw T* (5.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(T)40(a)-17(gk)-17(al)-31(idis)]TJ /Span<>> BDC ( )Tj EMC [(PP, T)45(jandr)-33(a)]TJ /Span<>> BDC ( )Tj EMC [(JJ. Chr)-32(onic r)-33(adia)15(t)-32(ion p)25(r)-32(o)-16(c)-16(t)-31.9(i)-24(t)-32(is. )]TJ /T1_1 1 Tf [(A)53(NZ J Surg)]TJ /T1_0 1 Tf 0 Tw (. )Tj 0.023 Tw -1.296 -1.25 Td [(2001 Ap)25(r;71\(4\):230\2267. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1046/j.1440-1622.2001.02081.x)Tj 0 0 0 1 k /GS1 gs 0.081 Tw T* (6.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Q)-16(uastler)]TJ /Span<>> BDC ( )Tj EMC [(H. Cell r)-24(enew)-12(al and a)-17(cute r)-33(adia)15(t)-32(ion d)42(ama)-16.9(ge. )]TJ /T1_1 1 Tf 0 Tw [(R)20.1(adiology)]TJ /T1_0 1 Tf (. )Tj 0.023 Tw -1.296 -1.25 Td [(1959;73:161\2265. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1148/73.2.161)Tj 0 0 0 1 k /GS1 gs -0.015 Tw 29.055 20 Td (7.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(S)-16(had)42(ad)]TJ /Span<>> BDC ( )Tj EMC 3.099 0 Td [(AK, )0.6(Sull)-31(i)-16(v)-15(an)]TJ /Span<>> BDC ( )Tj EMC 4.958 0 Td [(F)-10(J, )0.6(Mar)-22(t)-32(in)]TJ /Span<>> BDC ( )Tj EMC 4.156 0 Td [(JD, )0.5(e)-11.9(t)]TJ /Span<>> BDC ( )Tj EMC 2.458 0 Td [(al. )0.6(Gastr)-32(ointest)-32(inal )0.6(r)-33(adia)15(t)-32(ion )]TJ -0.02 Tw -15.967 -1.25 Td [(injur)-23.9(y: sym)10(pt)17(oms, r)-37(isk f)16(a)-16.9(c)-16(t)17(or)-10(s and mechanis)26(ms. )]TJ /T1_1 1 Tf [(W)29(orld J Gastroenterol.)]TJ /T1_0 1 Tf 0 Tw ( )Tj 0.023 Tw T* [(2013;19\(2\):185\22698. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.3748/wjg.v19.i2.185)Tj 0 0 0 1 k /GS1 gs 0.336 Tw T* (8.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(R)11(ober)-22(tson)]TJ /Span<>> BDC ( )Tj EMC [(I, L)35(eung)]TJ /Span<>> BDC ( )Tj EMC (E, Hughes)Tj /Span<>> BDC ( )Tj EMC [(D, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. P)35(r)-31.9(ospec)-16(t)-32(i)-16(ve anal)35(y)-12.9(sis )]TJ 0.209 Tw -1.296 -1.25 Td (of)Tj /Span<>> BDC ( )Tj EMC [(st)17(oma-r)-24(el)-15.9(a)15(ted com)10(pl)-31(ica)15(t)-32(ions. )]TJ /T1_1 1 Tf [(Colorectal )0.5(Dis.)]TJ /T1_0 1 Tf ( 2005;7\(3\):279\22685. )Tj 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1111/j.1463-1318.2005.00785.x)Tj 0 0 0 1 k /GS1 gs 0.211 Tw -1.847 -1.25 Td (9.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(L)35(enz)]TJ /Span<>> BDC ( )Tj EMC [(L, R)11(ohr)]TJ /Span<>> BDC ( )Tj EMC [(R, Nak)-17(ao)]TJ /Span<>> BDC ( )Tj EMC [(F, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Chr)-32(onic r)-33(adia)15(t)-32(ion p)25(r)-32(o)-16(c)-16(t)17(op)32(a)15(t)-12.9(hy: )]TJ -0.034 Tw -1.296 -1.25 Td (A)Tj /Span<>> BDC ( )Tj EMC [(p)25(r)-33(a)-17(c)-16(t)-32(ical r)-24(ev)-16(iew of)]TJ /Span<>> BDC ( )Tj EMC [(end)-16(oscopic tr)-23.9(ea)15(tment. )]TJ /T1_1 1 Tf [(W)29(orld J Gastrointest Surg.)]TJ /T1_0 1 Tf 0 Tw ( )Tj 0.023 Tw T* [(2016;8\(2\):151\22660. d)-15.9(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.4240/wjgs.v8.i2.151)Tj 0 0 0 1 k /GS1 gs 0.013 Tc 0.472 Tw T* (10.)Tj /Span<>> BDC ( )Tj EMC 1.847 0 Td (Zhou)Tj /Span<>> BDC ( )Tj EMC [(C, A)15.2(dler)]TJ /Span<>> BDC ( )Tj EMC [(DC, Beck)10.2(er)]TJ /Span<>> BDC ( )Tj EMC [(L, e)-11.8(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Ef)-55.8(fec)-15.9(t)-31.8(i)-15.8(ve tr)-23.8(ea)15.2(tment)13( )]TJ 0.018 Tc 0.636 Tw -1.847 -1.25 Td [(o)0.5(f)]TJ /Span<>> BDC 0.85 0 Td ( )Tj EMC [(c)0.5(h)0.5(r)-31.5(o)0.5(n)0.5(i)0.5(c)0.5( r)-32.5(a)0.5(d)0.5(i)0.5(a)15.5(t)-31.6(i)0.6(o)0.5(n p)25.5(r)-31.5(o)-15.5(c)-15.5(t)-31.5(i)-23.5(t)-31.4(i)0.5(s u)0.5(si)0.5(n)0.5(g)0.5( r)-32.5(a)0.5(d)0.5(i)0.5(o)0.5(f)0.5(r)-23.5(e)0.5(q)0.5(u)0.5(e)0.5(n)0.5(c)0.5(y)0.5( a)0.5(b)0.5(l)-15.5(a)]TJ 0 Tc 0 Tw 26.436 0 Td (-)Tj 0.017 Tc -0.017 Tw -27.286 -1.25 Td [(t)-31.5(i)0.6(o)0.5(n)0.5(.)0.5( )]TJ /T1_1 1 Tf 0.6 Tw 2.91 0 Td [(T)0.5(h)0.5(e)0.6(r)0.5(a)0.5(p)0.5( A)0.6(d)0.5(v)0.5( G)0.6(a)0.5(s)0.5(t)0.5(r)0.5(o)0.6(e)0.5(n)0.5(t)0.5(e)0.5(r)0.6(o)0.5(l)]TJ /T1_0 1 Tf 11.387 0 Td [(.)0.5( 2)0.6(0)0.5(0)0.5(9)0.5( J)0.5(a)0.6(n)0.5( 1)0.5(;)0.5(2)0.5(\()0.6(3)0.5(\))0.5(:)0.5(1)0.5(4)0.5(9)0.5(\226)0.6(1)0.5(5)0.5(6)0.5(.)17( )]TJ 0 Tc 0 Tw -14.298 -1.25 Td [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1177/1756283x08103341)Tj 0 0 0 1 k /GS1 gs -0.013 Tw -1.847 -1.25 Td (11.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Rust)15(a)-17(gi)]TJ /Span<>> BDC ( )Tj EMC [(T, Cor)-23.9(be)-12(t)-30(t)]TJ /Span<>> BDC ( )Tj EMC (FS, Mashimo)Tj /Span<>> BDC ( )Tj EMC [(H. T)50(r)-23.9(ea)15(tment of)]TJ /Span<>> BDC ( )Tj EMC [(chr)-32(onic r)-32.9(adia)15(t)-32(ion )]TJ 0.053 Tw -1.796 -1.25 Td [(p)25(r)-32(o)-16(c)-16(t)17(op)32(a)15(t)-12.9(hy wi)-24(t)-13(h r)-33(adiofr)-23.9(equency abl)-16(a)15(t)-32(ion \(wi)-23.9(t)-13(h v)-16(ideo\). )]TJ /T1_1 1 Tf 0 Tw (Gastrointest )Tj T* (Endosc)Tj /T1_0 1 Tf 0.023 Tw [(. 2015 F)10(eb;81\(2\):428\22636. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1016/j.gie.2014.04.038)Tj /T1_4 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\037\035\030\217\030\224\003\013\037\030\003 \217\n\206\035\204)15(\240\003\217\030\027)]TJ 54.711 0 Td [(C)10(A)20(SE REPORT)]TJ -54.711 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 2)69(4, \023\0224, 202)23(5)]TJ 43.013 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 2)69(4, \023\0224, 202)23(5)]TJ /T1_5 1 Tf 25 0 0 25 20.8528 56.0378 Tm (124)Tj ET endstream endobj 1555 0 obj <>/Border[0 0 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0 obj <> endobj 1588 0 obj <> endobj 1587 0 obj <> endobj 1586 0 obj <> endobj 1585 0 obj <> endobj 1584 0 obj <> endobj 1583 0 obj <> endobj 1582 0 obj <> endobj 1581 0 obj <> endobj 1580 0 obj <> endobj 1579 0 obj <> endobj 1578 0 obj <> endobj 1577 0 obj <> endobj 1576 0 obj <> endobj 1575 0 obj <> endobj 1574 0 obj <> endobj 1545 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\225\215\211\025\b\017)10(\025\222\021\f\016\b\017\001\004 \r\215\200)-20(\026\201\021\222\201\025\b\r\016\026\215\001\004 \201\001\211\021\025\f\001\ \b)-10(\026)11(\025\026\215\001\004 \001\235\t\004\212\021\004 )]TJ -0.003 Tw 0 -1 TD [(\r\022)2.8(\t\016\f\016\215\021\021 \222\001\212\021\016\215\026\017\021 \b\022)2.7(\201\025\215\021\f\016\b\017\021\024 \t\200\f\016\r\220\024 \222\201\025\ \017)-9.9(\026\021\026)11(\025\024, \025\b)-9.9(\t\025\216\215\243\215\215\220\024 )]TJ 0 Tw T* [(\201\016\212\021\211\021\r\021\201\200\205\232\021\024\021 \017\201\025\r\ \025\026)11(\016\f\016\215\021\004\024\021 \(\017)-9.9(\t\021\215\021\f\016\b\017\021\016 \215\001\235\t\205\211\016\215\021\004\ \))]TJ 36.767 2 Td [(Endoscopic intr)21(aluminal r)21(adiofr)31.1(equency ablation for chr)20.1(onic )]TJ -2.328 -1 Td [(r)21(adiation pr)20(octitis complicated b)10(y r)31(ecurr)31(ent bleeding \(case r)31(epor)-20(t\))]TJ /T1_1 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 42.5896 724.8299 Tm [(\037\036)10(\032\223\212\226\034\022\031\034)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf 0 Tc 0.294 Tw 10 0 0 10 42.5197 700.4739 Tm (\214\036\004\036\027\017\036 \023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\b\030\024\027\017\004\036\f\022\017\n \035\031\004\036\r\t\n \023\030\024\ \022)Tj /Span<>> BDC (-)Tj EMC 0.193 Tw 0 -1.218 TD [(\021\017\021\024\n \023\024-\023\030\036\032\027\036\n\031 \016\r\035\016\ \036\021\f\016 )0.5(\f\035\024\032\027\024\005 \022\035\017\027\017\004\036\f\022\024\005 )]TJ 0.4 Tw T* (\023\030\024\002\035\036\n\024\005. \203\036\f\n\024\021\030\016 \027\026\ )Tj /Span<>> BDC ( )Tj EMC (\r\t\f\024\022\017\005 \030\017\f\022 \030\026\r\017\021\017\016 )Tj 1.104 Tw T* (\023\024\f\035\036\024\023\036\030\026\006\017\024\027\027\t\b \024\f\035\ \024\032\027\036\027\017\005, \007\024\f\021\017\020\026\033\013\017\005\ , )Tj 0.361 Tw T* (\023\024)Tj /Span<>> BDC ( )Tj EMC (\027\036\022\024\021\024\030\t\n \007\026\027\027\t\n, 80%, \r\024 \n\027\ \024\020\017\b \022\035\017\027\017\022\026\b )Tj -0.022 Tw 0 -1.218 TD (\007\024)Tj /Span<>> BDC ( )Tj EMC [(\f\017\b \023\024\030 \024\021\007\026\033\021 \023\030\036\007\023\024\004\ \021\036\027\017\036 \030\026\007\017\022\026\035\034\027\t\n )0.5(\b\017\030\031\030)]TJ 0 Tw (-)Tj 0.353 Tw 0 -1.218 TD (\020\017\004\036\f\022\017\n \r\n\036\001\026\021\036\035\034\f\021\r\026\ \n. \216\017\030\031\030\020\017\004\036\f\022\024\036 \035\036\004\036\027\ \017\036 )Tj 0.038 Tw T* (\023\030\017)Tj /Span<>> BDC ( )Tj EMC (\007\026\027\027\024\n \026\002\024\035\036\r\026\027\017\017 \n\024\032\ \036\021 \r\022\035\033\004\026\021\034 \030\026\035\017\004\027\t\036 \ )Tj 0.059 Tw T* (\024\002\255\036\n\t \024\023\036\030\026\006\017\005, \f\030\036\007\017\ \022\024\021\024\030\t\b \235\024\030\n\017\030\024\r\026\027\017\036 \022\ \017)Tj 0 Tw (-)Tj -0.032 Tw T* (\001\036\004\027\024\005 \f\021\024\n\t, \030\036\036\022\006\017\016 \023\ \030\016\n\024\005 \022\017\001\022\017 \017\035\017 \036\036 \023\024\035\ \027\026\016 )Tj 0 Tw 0 -1.218 TD (\220\022\f\021\017\030\023\026\006\017\016 [2,3].)Tj 0.278 Tw 0 -1.218 TD (\203\026\022\024\023\035\036\027\027\t\005 \024\023\t\021 \023\030\017\n\ \036\027\036\027\017\016 \n\017\027\017\n\026\035\034\027\024 \017\027\r\ \026)Tj 0 Tw (-)Tj -0.017 Tw 0 -1.218 TD [(\017\r\027\t\b \220\027\007\024\f\022\024\023\017\004\036\f\022\017\b )0.5(\n\036\021\024\007\017\022 \035\036\004\036\027\017\016 \023\026\006\017\ \036\027\021\024\r )]TJ -0.048 Tw 0 -1.218 TD (\f)Tj /Span<>> BDC ( )Tj EMC (\b\030\024\027\017\004\036\f\022\017\n \035\031\004\036\r\t\n \023\030\024\ \022\021\017\021\024\n \023\024\r\024\035\016\036\021 \023\024\017\006\ \017)Tj 0 Tw (-)Tj 0.191 Tw 0 -1.218 TD [(\024\027\017\030\024\r\026\021\034 \026\030\020\024\027\024\023\035\026\ \n\036\027\027\031\033 )0.5(\007\036\f\021\030\031\022\006\017\033 \017)]TJ /Span<>> BDC ( )Tj EMC (\030\026\007\017\024)Tj /Span<>> BDC (-)Tj EMC 0.156 Tw 0 -1.218 TD (\004\026\f\021\024\021\027\031\033 \026\002\035\016\006\017\033 \022\026\ \022 \023\036\030\f\023\036\022\021\017\r\027\031\033 \026\035\034\021\036\ \030\027\026\021\017)Tj 0 Tw (-)Tj 0.188 Tw 0 -1.218 TD (\r\031 \r\t\f\024\022\024\021\030\026\r\n\026\021\017\004\027\t\n \b\017\ \030\031\030\020\017\004\036\f\022\017\n \024\023\036\030\026\006\017\016\ \n. )Tj 0.047 Tw 0 -1.218 TD (\210\f\027\024\r\027\t\n \023\030\017\027\006\017\023\024\n \007\026\027\ \027\t\b \n\036\021\024\007\017\022 \016\r\035\016\036\021\f\016 \022\024\ \027)Tj 0 Tw (-)Tj 0.516 Tw T* (\021\030\024\035\017\030\031\036\n\026\016 \007\036\f\021\030\031\022\006\ \017\016 \023\026\021\024\035\024\020\017\004\036\f\022\017 \017\n\036\027\ \036\027)Tj 0 Tw (-)Tj 0.164 Tw 0 -1.218 TD (\027\024\005 \f\035\017\017\f\021\024\005 \023\030\016\n\024\005 \022\017\ \001\022\017. \215\030\036\017\n\031\013\036\f\021\r\026\n\017 \220\027)Tj 0 Tw (-)Tj 0.815 Tw 0 -1.218 TD (\007\024\f\022\024\023\017\004\036\f\022\017\b \n\036\021\024\007\024\r \ \016\r\035\016\033\021\f\016 \n\017\027\017\n\026\035\034\027\026\016 )Tj 0.403 Tw 0 -1.218 TD [(\017\027\r\026\017\r\027\024\f\021\034, )0.6(\027\017\022\026\016 )0.5(\004\026\f\021\024\021\026 )0.5(\023\024\f\035\036\024\023\036\030\026\006\017\024\027\027\t\b )]TJ 0.096 Tw T* (\024\f\035\024\032\027\036\027\017\005 \017)Tj /Span<>> BDC ( )Tj EMC (\r\024\n\024\032\027\024\f\021\034 \023\024\r\021\024\030\027\024\020\024\ \r\t\023\024\035\027\036\027\017\016 )Tj -0.024 Tw T* (\023\030\024\006\036\007\031\030\t \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\027\026\035\017\004\017\017 \024\f\021\026\021\024\004\027\t\b \024\004\ \026\020\024\r \023\026\021\024\035\024\020\017)Tj 0 Tw (-)Tj T* (\004\036\f\022\017 \017\n\036\027\036\027\027\024\005 \f\035\017\017\f\ \021\024\005 \024\002\024\035\024\004\022\017 [9].)Tj 0.588 Tw T* (\200\023\036\030\r\t\036 \030\026\007\017\024\004\026\f\021\024\021\027\026\ \016 \026\002\035\016\006\017\016 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\b\030\024\027\017\004\036)Tj 0 Tw (-)Tj 0.385 Tw T* (\f\022\024\n \035\031\004\036\r\024\n \023\030\024\022\021\017\021\036 \002\ \t\035\026 \r\t\023\024\035\027\036\027\026 Zhou)Tj /Span<>> BDC ( )Tj EMC (C. )Tj 0.246 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (2009)Tj /Span<>> BDC ( )Tj EMC 3.431 0 Td (\020\024\007\031)Tj /Span<>> BDC ( )Tj EMC 2.289 0 Td [([10]. )0.5(\224\035\036\007\031\036\021 \024\021\n\036\021\017\021\034, )0.6(\004\021\024 \027\026)]TJ /Span<>> BDC ( )Tj EMC 13.77 0 Td (\f\036\020\024\007)Tj 0 Tw (-)Tj 0.443 Tw -19.489 -1.218 Td [(\027\016\001\027\017\005 \007\036\027\034 \024\021\f\031\021\f\021\r\031\ \033\021 )0.5(\022\030\031\023\027\t\036 \030\026\027\007\024\n\017\017\030\024)]TJ 0 Tw (-)Tj 0.099 Tw T* [(\r\026\027\027\t\036 )0.5(\017\f\f\035\036\007\024\r\026\027\017\016, )0.6(\024\006\036\027\017\r\026\033\013\017\036 )0.6(\220\235\235\036\022\021\017\r\027\024\f\021\034 )]TJ 0.379 Tw 23.244 37.752 Td (\017)Tj /Span<>> BDC ( )Tj EMC (\002\036\024\023\026\f\027\024\f\021\034 \007\026\027\027\024\005 \n\036\ \021\024\007\017\022\017. \230\036\n \027\036 \n\036\027\036\036, )Tj 0.351 Tw T* [(\023\036\030\f\023\036\022\021\017\r\027\024\f\021\034 )0.6(\030\026\007\017\024\004\026\f\021\024\021\027\024\005 )0.6(\026\002\035\016\006\017\017 )0.5(\023\024\007\004\036\030)]TJ 0 Tw (-)Tj 0.214 Tw T* (\022\017\r\026\036\021\f\016 \030\036\031\035\034\021\026\021\026\n\017\ \027\036\002\024\035\034\001\017\b \022\035\017\027\017\004\036\f\022\017\ \b \017\f)Tj 0 Tw (-)Tj 0.28 Tw T* [(\f\035\036\007\024\r\026\027\017\005. )0.6(\203\026\023\030\017\n\036\030, )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 11.485 0 Td [(\017\f\f\035\036\007\024\r\026\027\017\017 )0.6(Rust)15(a)-17(gi)]TJ /Span<>> BDC ( )Tj EMC 9.868 0 Td (T. )Tj 0.149 Tw -21.353 -1.218 Td (\017 \f\024\026\r\021., \r\022\035\033\004\026\033\013\036\n 39)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\b\030\024\027\017\004\036\f\022\017\n )Tj 0.216 Tw T* (\035\031\004\036\r\t\n \023\030\024\022\021\017\021\024\n, \002\t\035\026\ \023\030\024\007\036\n\024\027\f\021\030\017\030\024\r\026\027\026 \r\t\ )Tj 0 Tw (-)Tj 0.006 Tw T* [(\f\024\022\026\016 )0.5(\220\235\235\036\022\021\017\r\027\024\f\021\034 )0.5(\r\n\036\001\026\021\036\035\034\f\021\r\026, )0.6(\r\t\030\026\032\026\033\013\026\016\f\016 )]TJ 0.042 Tw 0 -1.218 TD (\r)Tj /Span<>> BDC ( )Tj EMC (\027\026\004\017\021\036\035\034\027\024\n \030\036\020\030\036\f\f\036\ \022\035\017\027\017\004\036\f\022\024\005 \f\017\n\023\021\024\n\026\021\ \017\022\017 )Tj 0.188 Tw 0 -1.218 TD (\017)Tj /Span<>> BDC ( )Tj EMC (\023\030\026\022\021\017\004\036\f\022\017 \023\024\035\027\024\n \024\021\ \f\031\021\f\021\r\017\017 \023\024\f\035\036\024\023\036\030\026\006\017\ \024\027)Tj 0 Tw (-)Tj 0.017 Tw T* [(\027\t\b )0.5(\024\f\035\024\032\027\036\027\017\005 )0.6([11]. )0.5(\200)]TJ /Span<>> BDC ( )Tj EMC 10.246 0 Td [(\007\024\f\021\031\023\027\024\005 )0.5(\035\017\021\036\030\026\021\031\030\036 )0.6(\027\026)]TJ /Span<>> BDC ( )Tj EMC 10.608 0 Td (\f\036)Tj 0 Tw (-)Tj 0.094 Tw -20.854 -1.218 Td (\020\024\007\027\016\001\027\017\005 \007\036\027\034 \024\021\f\031\021\ \f\021\r\031\033\021 \023\030\016\n\t\036 \f\030\026\r\027\017\021\036\035\ \034\027\t\036 )Tj 0.675 Tw T* [(\017\f\f\035\036\007\024\r\026\027\017\016, )0.6(\024\006\036\027\017\r\026\033\013\017\036 )0.5(\220\235\235\036\022\021\017\r\027\024\f\021\034 )0.6(\b\017)]TJ 0 Tw (-)Tj 0.316 Tw 0 -1.218 TD [(\030\031\030\020\017\004\036\f\022\017\b )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 6.749 0 Td [(\220\027\007\024\035\033\n\017\027\026\035\034\027\t\b )0.5(\220\027\007\024\f\022\024\023\017\004\036\f\022\017\b )]TJ 0 Tw -6.749 -1.218 Td (\023\024\007\b\024\007\024\r.)Tj 0.322 Tw T* (\200 \023\030\036\007\f\021\026\r\035\036\027\027\024\n \022\035\017\027\ \017\004\036\f\022\024\n \027\026\002\035\033\007\036\027\017\017 \027\026\ \n\017 )Tj 0.021 Tw 0 -1.218 TD (\002\t\035\017 \023\024\035\031\004\036\027\t \031\002\036\007\017\021\036\ \035\034\027\t\036 \002\035\017\032\026\005\001\017\036 \017)Tj /Span<>> BDC ( )Tj EMC (\024\021\007\026\035\036\027)Tj 0 Tw (-)Tj 0.243 Tw 0 -1.218 TD (\027\t\036 \030\036\031\035\034\021\026\021\t \035\036\004\036\027\017\016\ \023\026\006\017\036\027\021\022\017 \f)Tj /Span<>> BDC ( )Tj EMC (\b\030\024\027\017\004\036\f\022\017\n )Tj 0.157 Tw 0 -1.218 TD [(\035\031\004\036\r\t\n )0.5(\023\030\024\022\021\017\021\024\n, )0.6(\024\f\035\024\032\027\036\027\027\t\n )0.6(\030\036\006\017\007\017\r\017\030\031\033\013\017)]TJ 0 Tw (-)Tj 0.108 Tw 0 -1.218 TD (\n\017 \022\030\024\r\024\021\036\004\036\027\017\016\n\017 \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\016\n\024\005 \022\017\001\022\017. \200\t\023\024\035\027\036\027\ \027\026\016 )Tj 0.518 Tw 0 -1.218 TD [(\220\027\007\024\f\022\024\023\017\004\036\f\022\026\016 )0.6(\030\026\007\017\024\004\026\f\021\024\021\027\026\016 )0.5(\026\002\035\016\006\017\016 )0.6(\023\024\r\024)]TJ 0 Tw (-)Tj 0.185 Tw T* (\035\017\035\026 \027\036 \021\024\035\034\022\024 \r\t\023\024\035\027\017\ \021\034 \n\017\027\017\n\026\035\034\027\024 \017\027\r\026\017\r\027\024\ \036 )Tj 0.164 Tw 0 -1.218 TD (\035\036\004\036\027\017\036 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\f\021\024\035\034 \f\035\024\032\027\024\n \026\002\024\035\036\r\026\027\ \017\017, \027\024 \021\026\022\032\036 )Tj 0.116 Tw 0 -1.218 TD (\017\002\026\r\017\021\034 \023\026\006\017\036\027\021\022\031 \024\021\ \r\t\f\024\022\024\021\030\026\r\n\026\021\017\004\027\024\020\024 \b\017\ \030\031\030)Tj 0 Tw (-)Tj -0.021 Tw 0 -1.218 TD [(\020\017\004\036\f\022\024\020\024 )0.5(\r\n\036\001\026\021\036\035\034\f\021\r\026 )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC 11.406 0 Td [(\027\026\004\017\021\036\035\034\027\024 )0.6(\031\035\031\004\001\017\021\034 )0.6(\022\026)]TJ 0 Tw (-)Tj -11.406 -1.218 Td (\004\036\f\021\r\024 \036\036 \032\017\027\017.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 275.0305 396.0238 Tm [(\020)21(\026\027\r\241\224\034\022\031\034)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf 0 Tc 0.369 Tw 10 0 0 10 274.9606 371.6678 Tm [(\225\027\007\024\f\022\024\023\017\004\036\f\022\026\016 )0.6(\030\026\007\017\024\004\026\f\021\024\021\027\026\016 )0.5(\026\002\035\016\006\017\016 )0.5(\026\030\036\022\024)]TJ 0 Tw (-)Tj 0.503 Tw T* (\n\036\027\007\024\r\026\035\026 \f\036\002\016 \022\026\022 \f\024\r\030\ \036\n\036\027\027\t\005, \220\235\235\036\022\021\017\r\027\t\005 )Tj 0.203 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC [(\024\023\021\017\n\026\035\034\027\t\005 )0.5(\n\036\021\024\007 \035\036\004\036\027\017\016 )0.5(\002\024\035\034\027\t\b )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC (\b\030\024\027\017\004\036)Tj 0 Tw (-)Tj 0.077 Tw T* (\f\022\017\n \035\031\004\036\r\t\n \023\030\024\022\021\017\021\024\n, \ \016\r\035\016\016\f\034 \023\030\036\007\023\024\004\021\017\021\036\035\ \034\027\024\005 )Tj 0.003 Tw T* [(\026\035\034\021\036\030\027\026\021\017\r\024\005 )0.6(\021\030\026\007\017\006\017\024\027\027\t\n )0.6(\b\017\030\031\030\020\017\004\036\f\022\017\n )0.6(\r\n\036\001\026)]TJ 0 Tw (-)Tj 0.204 Tw T* (\021\036\035\034\f\021\r\026\n. \212\026\027\027\026\016 \n\036\021\024\007\ \017\022\026 \024\002\035\026\007\026\036\021 \030\016\007\024\n \023\030\ \017\027)Tj 0 Tw (-)Tj 0.033 Tw T* [(\006\017\023\017\026\035\034\027\t\b )0.5(\023\030\036\017\n\031\013\036\f\021\r, \f\030\036\007\017 \022\024\021\024\ \030\t\b \024\030\020\026\027\024\f\002\036)]TJ 0 Tw (-)Tj 0.239 Tw T* (\030\036\020\026\033\013\017\005 \b\026\030\026\022\021\036\030 \023\030\ \024\006\036\007\031\030\t, \n\017\027\017\n\026\035\034\027\t\005 \030\017\ \f\022 )Tj 0.016 Tw T* [(\024\f\035\024\032\027\036\027\017\005 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC [(\022\024\030\024\021\022\017\005 \023\024\f\035\036\024\023\036\030\026\006\ \017\024\027\027\t\005 )0.5(\023\036\030\017\024\007, )]TJ -0.027 Tw T* (\023\024\r\024\035\016\033\013\017\005 \023\026\006\017\036\027\021\026\ \n \002\t\f\021\030\024 \r\036\030\027\031\021\034\f\016 \022)Tj /Span<>> BDC ( )Tj EMC (\023\030\017\r\t\004)Tj 0 Tw (-)Tj 0.184 Tw T* [(\027\024\n\031 )0.5(\024\002\030\026\031 )0.5(\032\017\027\017 )0.5(\002\036 )0.5(\027\036\024\002\b\024\007\017\n\024\f\021\017 )0.5(\007\035\017\021\036\035\034\027\024\005 )]TJ 0.136 Tw T* (\030\036\026\002\017\035\017\021\026\006\017\017. \025\030\024\n\036 \021\ \024\020\024, \220\027\007\024\f\022\024\023\017\004\036\f\022\026\016 \030\ \026\007\017\024)Tj 0 Tw (-)Tj 0.034 Tw T* (\004\026\f\021\024\021\027\026\016 \026\002\035\016\006\017\016 \024\002\ \036\f\023\036\004\017\r\026\036\021 \r\t\f\024\022\031\033 \021\024\004\ \027\024\f\021\034\033 )Tj 0.131 Tw T* (\r\024\007\036\005\f\021\r\017\016 \027\036\023\024\f\030\036\007\f\021\ \r\036\027\027\024 \027\026)Tj /Span<>> BDC ( )Tj EMC (\023\026\021\024\035\024\020\017\004\036\f\022\017 \017)Tj 0 Tw (-)Tj 0.263 Tw T* [(\n\036\027\036\027\027\t\036 \021\022\026\027\017, \024\021\035\017\004\026\ \036\021\f\016 )0.5(\b\024\030\024\001\036\005 \023\036\030\036\027\024\f\017\n\024)]TJ 0 Tw (-)Tj 0.182 Tw T* (\f\021\034\033 \023\026\006\017\036\027\021\026\n\017 \017)Tj /Span<>> BDC ( )Tj EMC (\r\024\n\024\032\027\024\f\021\034\033 \023\024\r\021\024\030\027\024\020\ \024 \023\030\017)Tj 0 Tw (-)Tj 0.03 Tw T* (\n\036\027\036\027\017\016 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\027\036\024\002\b\024\007\017\n\024\f\021\017, \004\021\024 \007\036\035\ \026\036\021 \036\036 \024\f\024\002\036\027\027\024 )Tj 0.072 Tw T* (\023\030\017\r\035\036\022\026\021\036\035\034\027\024\005 \017)Tj /Span<>> BDC ( )Tj EMC (\r\024\f\021\030\036\002\024\r\026\027\027\024\005 \n\036\021\024\007\017\ \022\024\005 \r)Tj /Span<>> BDC ( )Tj EMC (\f\024)Tj 0 Tw (-)Tj T* (\r\030\036\n\036\027\027\024\005 \022\035\017\027\017\004\036\f\022\024\005\ \023\030\026\022\021\017\022\036.)Tj /T1_3 1 Tf 0.023 Tw 0 -2.436 TD (\224\030\032\255\020\034\036 \032\026\020\017\022\017\026)Tj /T1_2 1 Tf 0 Tw 0 -1.218 TD [(\025)-4.1(\024)-4.3(\027)1.7(\006)-6(\036)-6.8(\023)2.2(\006)-6(\017)-5.4(\016 \017)]TJ /Span<>> BDC ( )Tj EMC [(\007)-6(\017)2.7()-9.9(\026\005)1.8(\027 \017)-2.4(\f)3.1(\f)-38.9(\035)-6.8(\036)-19(\007)-4.4(\024)-4.3(\r)-8.9(\026\027)1.7(\017)-5.5(\016)13.7(:)]TJ /T1_4 1 Tf -0.01 Tc 0.01 Tw [( \207)-5.5(\035)-3.1(\037)-8.2(\033)-4.1(\021\034\036)]TJ /Span<>> BDC 18.582 0 Td ( )Tj EMC [(\234)16.6(.)19.3(\223)112(.)]TJ /T1_2 1 Tf 0 Tc 0 Tw -18.582 -1.218 Td [(\224)-4.6(\002)-9.9(\024)0.7(\030 \017)]TJ /Span<>> BDC ( )Tj EMC [(\024)-11.8(\002)3(\030)-11.3(\026)-6.4(\002)-9.9(\024)-10.8(\021)-17.7(\022)-19.1(\026 \n)1.3(\026)-11.8(\021)-9.9(\036)-1.7(\030)-7.6(\017)-0.6(\026)-33.1(\035\026)3.7(:)]TJ /T1_4 1 Tf -0.029 Tc 0.029 Tw [( )-17.2(\037)-16.8(\013)-22.5(\037)-27.1(\f)-24.5(\034)-19.4(\036)]TJ /Span<>> BDC 15.758 0 Td ( )Tj EMC [(\205)-31.3(.\200.)]TJ /T1_2 1 Tf 0.018 Tc 1.686 Tw -15.758 -1.218 Td [(\224)35.2(\021)-3.5(\026)6.2(\021\017)15.6(\f)-18(\021\017)22.5(\004)9.8(\036)7.6(\f)16.4(\022)-1.1(\026)-3(\016)18( \024)6.2(\002)21(\030)6.6(\026)11.7(\002)8.1(\024)7.1(\021\022)-1.1(\026)21.7(:)]TJ /T1_4 1 Tf -0.029 Tc 1.733 Tw 13.053 0 Td [( )-17.3(\037)-16.8(\013)-22.4(\037)-27.2(\f)-24.5(\034)-19.4(\036)]TJ /Span<>> BDC 5.234 0 Td ( )Tj EMC [(\205)-31.3(.\200.)-21.2(,)-29( )]TJ -0.01 Tc 0.01 Tw -18.287 -1.218 Td [(\255)0.9(\037)-8.3(\006)-5.9(\034\027)-6.7(\034)-10.3(\b)1.9(\005\022)-2.3(\021\034\036)]TJ /Span<>> BDC 5.726 0 Td ( )Tj EMC [(\213)83.9(.)-19.6(\n)-8.6(.)-2.1(,)-10( \n)-27.3(\201)11.4(\037)-5.7(\020)-2.3(\035)-2.5(\023)-24.4(\002)-2.4(\037)-5.7(\020)-6.2(\034\036)-7.9(\037)]TJ /Span<>> BDC 8.434 0 Td ( )Tj EMC [(\207)-12.1(.)18.5()14.3(.)]TJ ET q /GS0 gs 221.1023475 0 0 175.0093554 42.5196833 155.0211471 cm /Im0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0 Tc 0.016 Tw 9 0 0 9 42.5197 144.1701 Tm (\022\t\217\210\b\002\220 3.)Tj 0 0 0 1 k /GS1 gs /T1_4 1 Tf ( \r\034\020\035\033\034\027\003\020\037\030 \021\034\027\034\020\034\024\ \021\034\f\022\030: \f\033\022)Tj /Span<>> BDC ( )Tj EMC (\034\024\006\034\035\033\016 \036)Tj /Span<>> BDC ( )Tj EMC (\022\020)Tj 0 Tw (-)Tj 0.064 Tw 0 -1.2 TD (\036\016\033\024\022\022 \036)Tj /Span<>> BDC ( )Tj EMC (\034\025\027\037\024\035\022 \031\023\025\005\037\035\034\004 \027\022\020\ \022\022 \f\033\022\031\020\037\021\034\036 \034\024\035\037\035\034\005\ \020\032\002 )Tj 0.149 Tw T* [(\035\016\027\016\037\020\013\022\034\220\021\035\037\031\022\004 )0.5(\020\016 \036\032\030\036\027\016\020\034. \207\027\022\031\022\024\035\037\ \030 )0.5(\034\025\034\027\034\005\021\037 \025\016\031 )]TJ 0 Tw T* (\f\037\035\034\027\034\013\022\005\016\024\021\022\002 \022\031\006\016\020\ \016\020\022\004)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf -0.047 Tw T* [(F)-16(igure 3.)]TJ 0 0 0 1 k /GS1 gs /T1_4 1 Tf [( F)12(ollow-up colonoscop)12(y)12(: upon retrof)-21.9(le)-15(x)10(ed e)-15(x)10(amination )]TJ 0.129 Tw T* (at the)Tj /Span<>> BDC ( )Tj EMC (dentate line, no signs of)Tj /Span<>> BDC ( )Tj EMC [(residual telangiectasias w)12(ere )]TJ 0 Tw T* [(identif)-42.9(ied. The)]TJ /Span<>> BDC ( )Tj EMC [(mucosa appears without pathological chang)12.4(es)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\037\035\030\217\030\224\003\013\037\030\003 \217\n\206\035\204)15(\240\003\217\030\027)]TJ 54.711 0 Td [(C)10(A)20(SE REPORT)]TJ /T1_5 1 Tf 25 0 0 25 505.4771 56.0378 Tm (123)Tj ET endstream endobj 1546 0 obj <>stream Adobed     '$''''$25552;;;;;;;;;;   ####''',,,   ####''',,,   ####''',,,m""  !1AQa"q2B#R $%&'()*3456789:CDEFGHIJSTUVWXYZbcdefghijrstuvwxyz!1AQ"a2qBR#b $%&'()*3456789:CDEFGHIJSTUVWXYZcdefghijrstuvwxyz?I$WBI$!BI$ T$ЎXOLeb[7óm حXqn4L*MY{X?s{`c|ċP>{v{[{W3؞ cc3ϻ\6@<В /hIehlUBNT`AċP T!Jgi R&`ؕP *B(AN".#rcql)Uͤ(HdZH$ ܫE:! `sZo˜t)DTnRB*k`I4@0D%Ҝ:B6$TUB+e :̠֓%B MqqsmAvAﲓ(Bݚ,Lא,{"P$!Bƪ!UK&Ȳ3js!QkA*YnOEfUT!U7Uk:X@<4!TSM+2(SnT4!TmHSB=(sy{TB[i[zRaX(tB].\eNmUP!W̦ .e7EBM-]A-VM'r B 8Rn֥18J}zK8H#z $8'n w[GdRM ͍Mzg}_s{7Ƙ y ~`Bhk75 S`abkD۬z!$λ)$6k\r HRq1pav@H]*).5z&!鄖6\i7O>#Epͩ_-gsh0T#(i29Q~0o0psqX0/y9X2MȠ)#z;p1z]stWLuxX/G|!I$WBI$!P'Ba@4ۼ˟ 8ڽ2" f=(54TY; xW{]{V.=;[1[vCӹו{Z{T|?z+zKiWhqٜ88I$dnI [yNXڜ7MBRkm䀜pUTy!B=֒q$RSv)E6B(TVs6ZT}͕nB:R s5Lj4ʚ)BBqnpi.Sfʓ|I-H6jV' +fk!Lɸf5L`@b!@1FmQt#0 frȉZTML&]XLPv0(hAS)'LuBd .8a*ٛEcJ4݈uX]1Lo"!;MI`A$B 1:nͰn ̧sHRF!B(Ol\EU1&WCZ"]B5wJNٽ*$Д#D!W1YF0f1uuYP! 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dYi*e_sKy*@ S3!K"d *ǹ+@` R7V;r5YM/$AfBg!sC}2TU*["K[ B,YəJiNkS0* sTB}%y'qV6qSZoTJi;7QhFZ.MU1 F ʛy`9ʭ3!R KI ihV7VfmxMJfN]I+ f܊ U jkjH;+tV:x颷dP'Ph|yAwo*4`B9lv+\ܗDG2K,{2uVƬi5L澥siL.lS4h;ћ7Tg_!LËj"`ANf ]g;%@07KsuUaiU J}pQb D@%3uBs7Z*ĺnxx'H5MG:uܤX}4HZrN$&hS[-*I\ui%A|EK1Z Bj7qB׀"FUfژʣ);d_ Ƈ>&NK6 ͪs*}U `骹0㕠Lvab r6i9ȕVW+YPgPi `S ˎ](&5xܬ=/we`6ߙSѺ'I{ptvjv;܌ 7; =΁0%ϊ[I$T!$IRI$BB endstream endobj 1593 0 obj <>stream endstream endobj 1542 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.004 Tc 0.116 Tw 10 0 0 10 70.8661 724.8299 Tm (\f\021\024\n\t. \210\007\027\026\022\024 \023\026\006\017\036\027\021\022\ \026 \024\021 \023\030\036\007\035\024\032\036\027\027\024\020\024 \024\023\ \036\030\026)Tj 0 Tc 0 Tw (-)Tj 0.004 Tc 0 -1.218 TD (\021\017\r\027\024\020\024 \035\036\004\036\027\017\016 \024\021\022\026\ \026\035\026\f\034.)Tj 0 Tc 0.177 Tw T* (\215\030\017 \024\002\f\035\036\007\024\r\026\027\017\017 \r)Tj /Span<>> BDC ( )Tj EMC (\027\026\001\036\n \037\036\027\021\030\036, 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BDC ( )Tj EMC (\f\n, \r\017\031\026\035\017\017\030\024\r\026\035\017\f\034 \n\027\024\ \032\036)Tj 0 Tw (-)Tj 0.235 Tw T* (\f\021\r\036\027\027\t\036 \031\004\026\f\021\022\017 \021\036\035\036\026\ \027\020\017\024\220\022\021\026\017\005 \r)Tj /Span<>> BDC ( )Tj EMC (\r\017\007\036 \030\026\f\001\017)Tj 0 Tw (-)Tj 0.146 Tw T* (\030\036\027\027\t\b \023\024\007\f\035\017\017\f\021\t\b \f\024\f\031\007\ \024\r \016\030\022\024-\022\030\026\f\027\024\020\024 \006\r\036\021\026\ , )Tj -0.007 Tw T* (\035\036\020\022\024 \022\024\027\021\026\022\021\027\024 \022\030\024\r\ \024\021\024\004\026\013\017\b \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\f\024\023\030\017\022\024\f\027\024\r\036\027\017\017 )Tj 0 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\007\017\f\021\026\035\034\027\t\n \022\024\027\006\024\n \220\027\007\024\ \f\022\024\023\026 \(\217\017\f.)Tj /Span<>> BDC ( )Tj EMC (1\).)Tj 0.459 Tw 0 -1.218 TD (\211\004\017\021\t\r\026\016 \027\026\035\017\004\017\036 \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\022\017 \030\036\006\017\007\017\r\017\030\031\ \033\013\017\b )Tj 0.238 Tw 0 -1.218 TD [(\022\030\024\r\024\021\036\004\036\027\017\005 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC [(\023\030\016\n\024\005 )0.5(\022\017\001\022\017 \027\026)]TJ /Span<>> BDC ( )Tj EMC 15.732 0 Td [(\235\024\027\036 )0.5(\b\030\024\027\017\004\036)]TJ 0 Tw (-)Tj 0.13 Tw -15.732 -1.218 Td [(\f\022\024\020\024 )0.5(\035\031\004\036\r\024\020\024 )0.6(\023\030\024\022\021\017\021\026 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 11.642 0 Td [(\024\021\f\031\021\f\021\r\017\036 )0.6(\022\035\017\027\017\004\036\f\022\024\020\024 )]TJ 0.158 Tw -11.642 -1.218 Td [(\220\235\235\036\022\021\026 )0.6(\024\021 )0.5(\022\024\027\f\036\030\r\026\021\017\r\027\024\005 )0.5(\021\036\030\026\023\017\017, )0.5(\002\t\035\024 )0.5(\023\030\017\027\016\021\024 )]TJ 0.285 Tw 0 -1.218 TD (\030\036\001\036\027\017\036 \024)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\r\036\007\036\027\017\017 \220\027\007\024\f\022\024\023\017\ \004\036\f\022\024\005 \030\026\007\017\024\004\026)Tj 0 Tw (-)Tj 0.412 Tw T* (\f\021\024\021\027\024\005 \026\002\035\016\006\017\017 \023\026\021\024\ \035\024\020\017\004\036\f\022\017 \017\n\036\027\036\027\027\024\005 \f\ \035\017)Tj 0 Tw (-)Tj 0.321 Tw T* [(\017\f\021\024\005 \024\002\024\035\024\004\022\017 \023\030\016\n\024\005\ )0.5(\022\017\001\022\017. \225\027\007\024\f\022\024\023\017\004\036\f\022\024\ \036 )]TJ 0.047 Tw T* (\r\n\036\001\026\021\036\035\034\f\021\r\024 \r\t\023\024\035\027\036\027\ \024 \r)Tj /Span<>> BDC ( )Tj EMC (\031\f\035\024\r\017\016\b \024\023\036\030\026\006\017\024\027\027\024\005\ )Tj 0.049 Tw T* (\023\024\007 \r\027\031\021\030\017\r\036\027\027\024\005 \026\027\036\f\ \021\036\017\036\005. \212\035\016 \r\t\023\024\035\027\036\027\017\016\ \023\030\024)Tj 0 Tw (-)Tj 0.169 Tw T* (\006\036\007\031\030\t \017\f\023\024\035\034\024\r\026\035\f\016 \020\026\ \f\021\030\024\f\022\024\023 \f)Tj /Span<>> BDC ( )Tj EMC (\031\f\021\026\027\024\r\035\036\027\027\t\n )Tj 0.295 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC (\036\020\024 \007\017\f\021\026\035\034\027\024\n \022\024\027\006\036 \022\ \026\021\036\021\036\030\024\n \007\035\016 \030\026\007\017\024\004\026\ )Tj 0 Tw (-)Tj 0.136 Tw T* [(\f\021\024\021\027\024\005 \026\002\035\016\006\017\017 \(Bar)-23.9(r)-33(x)]TJ 0 Tw 5.83 0 0 5.83 170.1989 448.0658 Tm (TM)Tj 0.136 Tw 10 0 0 10 176.7751 444.7358 Tm ( 90\) \030\026\n\036\030\024\n 20)Tj /Span<>> BDC ( )Tj EMC (\327)Tj /Span<>> BDC ( )Tj EMC (13)Tj /Span<>> BDC ( )Tj EMC (\n\n. )Tj 0.313 Tw -10.591 -1.218 Td (\215\030\017)Tj /Span<>> BDC ( )Tj EMC (\n\024\027\021\026\032\036 \022\026\021\036\021\036\030 \023\024\017\006\ \017\024\027\017\030\024\r\026\035\017 \r)Tj /Span<>> BDC ( )Tj EMC (\027\017\032\027\036\005 )Tj 0.319 Tw T* (\023\024\035\031\024\022\030\031\032\027\024\f\021\017 \023\024\035\016 \ \030\036\027\017\016 \220\027\007\024\f\022\024\023\026, \004\021\024 \024\ \002\036)Tj 0 Tw (-)Tj 0.106 Tw T* (\f\023\036\004\017\r\026\035\024 \024\023\021\017\n\026\035\034\027\t\005\ \r\017\031\026\035\034\027\t\005 \022\024\027\021\030\024\035\034 \017\ )Tj /Span<>> BDC ( )Tj EMC (\r\t)Tj 0 Tw (-)Tj 0.09 Tw T* (\f\024\022\031\033 \021\024\004\027\024\f\021\034 \n\026\027\017\023\031\ \035\016\006\017\005. \215\024\007 \220\027\007\024\f\022\024\023\017\004\ \036\f\022\017\n )Tj 0.152 Tw T* (\022\024\027\021\030\024\035\036\n \022\026\021\036\021\036\030 \002\t\035\ \023\030\024\r\036\007\036\027 \r)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\f\r\036\021 \023\030\016\n\024\005 )Tj 0.005 Tw T* (\022\017\001\022\017 \017)Tj /Span<>> BDC ( )Tj EMC (\031\f\021\026\027\024\r\035\036\027 \027\026)Tj /Span<>> BDC ( )Tj EMC (5 \n\n \023\030\024\022\f\017\n\026\035\034\027\036\036 \031\002\004\026\ \021\024\005 )Tj 0.092 Tw T* (\035\017\027\017\017 \007\035\016 \023\030\036\007\024\021\r\030\026\013\ \036\027\017\016 \021\030\026\r\n\026\021\017\026\006\017\017 \026\027\026\ \035\034\027\024)Tj 0 Tw (-)Tj -0.01 Tw T* (\020\024 \f\235\017\027\022\021\036\030\026 \017)Tj /Span<>> BDC ( )Tj EMC (\f\027\017\032\036\027\017\016 \030\017\f\022\026 \023\024\f\035\036\024\ \023\036\030\026\006\017\024\027\027\024\020\024 )Tj 0.259 Tw T* (\002\024\035\036\r\024\020\024 \f\017\027\007\030\024\n\026. \215\024\f\035\ \036\007\024\r\026\021\036\035\034\027\024 \r\t\023\024\035\027\016\035\026\ \f\034 )Tj 0.057 Tw T* (\007\r\031\022\030\026\021\027\026\016 \007\036\f\021\030\031\022\006\017\ \016 \f\035\017\017\f\021\024\005 \024\002\024\035\024\004\022\017 \f)Tj /Span<>> BDC ( )Tj EMC (\023\024\f\035\036)Tj 0 Tw (-)Tj 0.343 Tw T* [(\007\031\033\013\017\n \023\036\030\036\n\036\013\036\027\017\036\n )0.5(\022\026\021\036\021\036\030\026 \027\026)]TJ /Span<>> BDC ( )Tj EMC (\023\030\017\035\036\020\026\033\013\017\005 )Tj 0.014 Tw T* (\031\004\026\f\021\024\022 \f)Tj /Span<>> BDC ( )Tj EMC (\027\036\002\024\035\034\001\017\n \023\036\030\036\022\030\t\021\017\036\ \n \030\026\027\036\036 \026\002\035\017\030\024\r\026\027)Tj 0 Tw (-)Tj 0.266 Tw T* [(\027\024\005 )0.5(\024\027\t. )0.5(\215\024\f\035\036 )0.5(\026\r\036\030\001\036\027\017\016 )0.5(\023\024\035\027\024\006\036\027\027\024\005 )0.6(\006\017\030\022\031)]TJ 0 Tw (-)Tj 0.046 Tw T* [(\035\016\030\027\024\005 )0.6(\024\002\030\026\002\024\021\022\017 )0.5(\f\035\017\017\f\021\024\005 )0.6(\024\002\024\035\024\004\022\017 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 17.32 0 Td (\007\017\f\021\026\035\034\027\024\n )Tj 0.354 Tw -17.32 -1.218 Td (\f\036\020\n\036\027\021\036 \023\024\030\026\032\036\027\017\016 \022\026\ \021\036\021\036\030 \023\036\030\036\n\036\013\026\035\017 \023\030\024\ \022\f\017)Tj 0 Tw (-)Tj 0.066 Tw T* (\n\026\035\034\027\036\036 \f)Tj /Span<>> BDC ( )Tj EMC (\f\024\b\030\026\027\036\027\017\036\n \027\036\002\024\035\034\001\024\020\ \024 \023\036\030\036\022\030\t\021\017\016 \031\032\036 )Tj 0.288 Tw T* (\024\002\030\026\002\024\021\026\027\027\024\020\024 \007\017\f\021\026\035\ \034\027\024\020\024 \031\004\026\f\021\022\026 \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\007\024\035\032\026\035\017 )Tj 0.074 Tw T* (\r\t\023\024\035\027\016\021\034 \006\017\030\022\031\035\016\030\027\031\ \033 \026\002\035\016\006\017\033 \007\024)Tj /Span<>> BDC ( )Tj EMC (\023\024\035\027\024\020\024 \024\b\r\026\021\026 )Tj -0.027 Tw T* (\r\f\036\005 \024\027\t \023\026\021\024\035\024\020\017\004\036\f\022\017\ \017\n\036\027\036\027\027\024\005 \f\035\017\017\f\021\024\005 \024\002\ \024)Tj 0 Tw (-)Tj T* (\035\024\004\022\017 \023\030\016\n\024\005 \022\017\001\022\017.)Tj 0.138 Tw T* (\215\024\f\035\036\024\023\036\030\026\006\017\024\027\027\t\005 \023\036\ \030\017\024\007 \023\030\024\021\036\022\026\035 \002\036 \024\f\035\024\ \032\027\036)Tj 0 Tw (-)Tj 0.262 Tw T* [(\027\017\005. )0.5(\200)]TJ /Span<>> BDC ( )Tj EMC 3.378 0 Td [(\030\026\027\027\036\n )0.5(\023\024\f\035\036\024\023\036\030\026\006\017\024\027\027\024\n )0.5(\023\036\030\017\024\007\036 )0.6(\023\026\006\017)]TJ 0 Tw (-)Tj 0.153 Tw -3.378 -1.218 Td (\036\027\021\022\026 \024\021\n\036\004\026\035\026 \027\036\027\026\004\ \017\021\036\035\034\027\t\036 \002\024\035\036\r\t\036 \024\013\031\013\ \036\027\017\016 )Tj 0.042 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\026\027\024\030\036\022\021\026\035\034\027\024\005 \024\002\035\026\f\021\ \017, \022\024\021\024\030\t\036 \002\t\035\017 \031\f\023\036\001\027\024\ \022\031)Tj 0 Tw (-)Tj T* (\023\017\030\024\r\026\027\t \027\026)Tj /Span<>> BDC ( )Tj EMC (\235\024\027\036 \022\024\027\f\036\030\r\026\021\017\r\027\024\005 \021\ \036\030\026\023\017\017.)Tj 0.076 Tw T* (\212\035\016 \024\006\036\027\022\017 \030\036\031\035\034\021\026\021\024\ \r \035\036\004\036\027\017\016 \004\036\030\036 3 \n\036\f\016\006\026\ \023\024)Tj 0 Tw (-)Tj 0.1 Tw T* [(\f\035\036 )0.5(\024\023\036\030\026\006\017\017 )0.6(\002\t\035\026 )0.5(\r\t\023\024\035\027\036\027\026 )0.5(\022\024\027\021\030\024\035\034\027\026\016 )0.6(\022\024\035\024\027\024)]TJ 0 Tw (-)Tj 0.062 Tw T* [(\f\022\024\023\017\016. )0.6(\215\024)]TJ /Span<>> BDC ( )Tj EMC [(\007\026\027\027\t\n )0.6(\017\f\f\035\036\007\024\r\026\027\017\016, )0.6(\r)]TJ /Span<>> BDC ( )Tj EMC 15.351 0 Td [(\024\027\036 )0.5(\030\026\027\036\036 )0.5(\023\030\024)]TJ 0 Tw (-)Tj 0.459 Tw -15.351 -1.218 Td (\r\036\007\036\027\027\024\005 \026\002\035\016\006\017\017 \r\017\031\026\ \035\017\017\030\024\r\026\035\017\f\034 \031\n\036\030\036\027\027\t\036\ )Tj 0.374 Tw T* [(\030\031\002\006\024\r\t\036 \017\n\036\027\036\027\017\016 )0.5(\f\035\017\017\f\021\024\005 \024\002\024\035\024\004\022\017 \023\030\016\ \n\024\005 )]TJ 0.372 Tw 23.244 64.543 Td (\022\017\001\022\017 \f)Tj /Span<>> BDC ( )Tj EMC (\027\026\035\017\004\017\036\n \036\007\017\027\017\004\027\t\b \024\f\021\ \026\021\024\004\027\t\b \024\004\026\020\024\r )Tj 0.287 Tw 0 -1.218 TD [(\021\036\035\036\026\027\020\017\024\220\022\021\026\017\005 )0.6(\027\036\002\024\035\034\001\017\b )0.6(\030\026\n\036\030\024\r. )0.5(\215\030\017\027\026\022\024\r )]TJ 0.23 Tw 0 -1.218 TD (\f\021\036\027\024\026 \017\035\017 \f\021\030\017\022\021\031\030\t \023\ \030\024\f\r\036\021\026 \023\030\016\n\024\005 \022\017\001\022\017 \027\ \036 )Tj 0.201 Tw 0 -1.218 TD (\r\t\016\r\035\036\027\024 \(\217\017\f.)Tj /Span<>> BDC ( )Tj EMC (2, 3\). \025\035\017\027\017\004\036\f\022\017\036 \023\030\024\016\r\035\ \036\027\017\016 \026)Tj 0 Tw (-)Tj 0.067 Tw 0 -1.218 TD (\002\024\035\036\r\026\027\017\016, \021\026\022\017\036 \022\026\022 \002\ \024\035\036\r\024\005 \f\017\027\007\030\024\n \017)Tj /Span<>> BDC ( )Tj EMC (\022\030\024\r\024\021\036\004\036)Tj 0 Tw (-)Tj 0.255 Tw 0 -1.218 TD (\027\017\016 \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\016\n\024\005 \022\017\001\022\017, \023\024\035\027\024\f\021\034\ \033 \030\036\020\030\036\f\f\017\030\024\r\026\035\017. )Tj -0.032 Tw 0 -1.218 TD (\215\030\017)Tj /Span<>> BDC ( )Tj EMC [(\023\024\r\021\024\030\027\024\005 )0.5(\022\024\035\024\027\024\f\022\024\023\017\017 )0.5(\004\036\030\036 )0.5(3 \020\024\007\026 \023\030\017\027\026\022\024\r )]TJ 0 Tw 0 -1.218 TD (\030\036\006\017\007\017\r\026 \026\002\024\035\036\r\026\027\017\016 \027\ \036 \r\t\016\r\035\036\027\024.)Tj ET q 303.307 436.289 221.102 173.759 re W n q /GS0 gs 221.1023475 0 0 173.8090202 303.307086 436.2398515 cm /Im0 Do Q Q BT 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0.228 Tw 9 0 0 9 303.3071 425.4896 Tm (\022\t\217\210\b\002\220 1.)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf ( \r\034\027\034\020\034\024\021\034\f\022\030: \036\032\033\037\201\016\020\ \020\032\016 \f\033\022\031\020\037\021\022 \002\033\034\020\022)Tj 0 Tw (-)Tj 0.255 Tw 0 -1.2 TD (\005\016\024\021\034\013\034 \027\023\005\016\036\034\013\034 \f\033\034\ \021\035\022\035\037 \024)Tj /Span<>> BDC ( )Tj EMC (\020\037\027\022\005\022\016\006 \006\020\034\201\016\024\035\036\016\020\ \020\032\002 )Tj 0.155 Tw T* (\023\005\037\024\035\021\034\036 \035\016\027\016\037\020\013\022\034\220\ \021\035\037\031\022\004 \024\027\022\031\022\024\035\034\004 \034\025\034\ \027\034\005\021\022 \f\033\030\006\034\004 )Tj 0 Tw T* (\021\022\001\021\022)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0.095 Tw T* [(F)-16(igure 1)47(.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf [( Colonoscop)12(y)12(: p)45.9(ronounced signs of)]TJ /Span<>> BDC ( )Tj EMC (chronic radiation )Tj 0.02 Tw T* [(p)46(roctitis with multiple areas of)]TJ /Span<>> BDC ( )Tj EMC (telangiectasia in the)Tj /Span<>> BDC ( )Tj EMC (rectal mu)Tj 0 Tw (-)Tj T* (cosa)Tj ET q /GS0 gs 221.1023475 0 0 173.5689475 303.3070555 176.6167565 cm /Im1 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0.274 Tw 9 0 0 9 303.3071 165.7701 Tm [(\022\t\217\210\b\002\220 )0.6(2.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf [( )0.5(\r\034\020\035\033\034\027\003\020\037\030 )0.7(\021\034\027\034\020\034\024\021\034\f\022\030: )0.6(\034\035\005\016\035\027\022\036\034 )0.7(\036\022)]TJ 0 Tw (-)Tj 0.212 Tw T* (\031\023\037\027\022\031\022\033\023\026\035\024\030 \f\033\022\031\020\037\ \021\022 \033\023\025\007\034\036\032\002 \022\031\006\016\020\016\020\022\ \004 \024\027\022\031\022\024\035\034\004 )Tj -0.017 Tw T* (\034\025\034\027\034\005\021\022 \f\033\030\006\034\004 \021\022\001\021\ \022 \f\034\024\027\016 \033\037\020\016\016 \036\032\f\034\027\020\016\020\ \020\034\004 \033\037\b\022\034\005\037)Tj 0 Tw (-)Tj 0.063 Tw T* (\024\035\034\035\020\034\004 \037\025\027\030\007\022\022, \037)Tj /Span<>> BDC ( )Tj EMC (\035\037\021\201\016 \016\b\022\020\022\005\020\032\016 \034\024\035\037\ \035\034\005\020\032\016 \034\005\037\013\022 )Tj 0 Tw T* (\035\016\027\016\037\020\013\022\220\021\035\037\031\022\004)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf -0.034 Tw T* [(F)-16(igure 2)16(.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf [( F)12(ollow-up colonoscop)12.1(y clearly visualizes signs of)]TJ /Span<>> BDC ( )Tj EMC (cica)Tj 0 Tw (-)Tj 0.124 Tw T* [(tr)-37(icial chang)12(es in the)]TJ /Span<>> BDC ( )Tj EMC [(rectal mucosa following p)46(reviously per)]TJ 0 Tw 24.271 0 Td (-)Tj -0.033 Tw -24.271 -1.2 Td [(for)-14(med radiofreq)14.1(uency ablation, as w)12(ell as isolated residual foci )]TJ 0 Tw T* (of)Tj /Span<>> BDC ( )Tj EMC (telangiectasia)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\037\035\030\217\030\224\003\013\037\030\003 \217\n\206\035\204)15(\240\003\217\030\027)]TJ 54.711 0 Td [(C)10(A)20(SE REPORT)]TJ -54.711 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 2)69(4, \023\0224, 202)23(5)]TJ 43.013 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 2)69(4, \023\0224, 202)23(5)]TJ /T1_4 1 Tf 25 0 0 25 20.7653 56.0378 Tm (122)Tj ET endstream endobj 1543 0 obj <>stream Adobed     '$''''$25552;;;;;;;;;;   ####''',,,   ####''',,,   ####''',,,k""  !1A"Qaq2#RBC $%&'()*3456789:DEFGHIJSTUVWXYZbcdefghijrstuvwxyz8K!1AQa"q2BR# 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bn}RJBRDk%P.(rY.87 _%F(V^ PF$_*!RprR QEWڐN{]qqhl*[,ຨE)5H^gD @AGQEMh0PVqҢ]X l)*  (ܩĮK0Y5WmK( d 5_oT (YEQF$psZՄtQE'+6@kNz(Kq jƗMt:|Fh}}_ɚ&i:p5I%kzר[vmXo,E'o I$T*@I$EI$QEQDVrLUPpo$Zn=tAZ"ۥvTi4)ÅFcSD 4I\مgU5U&ⴕK^`:m; r l˞)u ֌;cb/v dݖLЦLHT4=v/`?P ؕIrtH1Sm#5 O7AT+^ުԮrril YDXqK!ZLUH@U5{9&7~Oj4Jj g+.] 4zBKoB`ЪD Ta& -t5DX]0XgU֧zXoe{ g5+̙x]D=WZ%6b lye]nMҪ--qnXv \d2[Y؁W y$Z.@QȒ Dk\@% 4Ij6j,2M|&*$f \'hm LPi9cw^ {xQ Sj"UvZn sWْ:Bg$lJ>+ GI;as[Z4$({هIVBEiWU*Vu (,R k΅jdi\vaeQ U<cUPk&65RʆJ(\K@DS%RI%YfTJo7ڠ.9Mx(߹EQJ1LU$cnpd*.h_RTQEU^h1+|wu¢S(.`RL֒.!$C.dK*G i)U9qT(ɓ & [2Yo͢6n aU]bE֫Wz WX4y cXv5gs2 {هiR8@?T+GЗ9I8XUk.Vo+֪}f6ɾK"UGKX~b~WVCflm64l6:v[-"h0xΩ$J($I((I$EJI$QE(I$QD6CU. &ު*zj:Ɲcqciv*5b;ke@;l)ݙ%Fݨ䓃U9͂UVw2ogsx/Mʞ > JSh­YfP4ϮJT.R6vr%7ˮ@'B6mL[S9 5/* OªK* !X6e.GcԬ)ɇ$WJmi1"CUO&QH'7JV%•Q,z |#$UV+,9*C6֖7REvxµ4\+iY͆KyZy'䆤vUnk:es|#g_"e )I$kj:6~@QM#QQKPsQkns[I$HV$J((I$( endstream endobj 1595 0 obj <>stream endstream endobj 1594 0 obj <>stream endstream endobj 1541 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\225\215\211\025\b\017)10(\025\222\021\f\016\b\017\001\004 \r\215\200)-20(\026\201\021\222\201\025\b\r\016\026\215\001\004 \201\001\211\021\025\f\001\ \b)-10(\026)11(\025\026\215\001\004 \001\235\t\004\212\021\004 )]TJ -0.003 Tw 0 -1 TD [(\r\022)2.8(\t\016\f\016\215\021\021 \222\001\212\021\016\215\026\017\021 \b\022)2.7(\201\025\215\021\f\016\b\017\021\024 \t\200\f\016\r\220\024 \222\201\025\ \017)-9.9(\026\021\026)11(\025\024, \025\b)-9.9(\t\025\216\215\243\215\215\220\024 )]TJ 0 Tw T* [(\201\016\212\021\211\021\r\021\201\200\205\232\021\024\021 \017\201\025\r\ \025\026)11(\016\f\016\215\021\004\024\021 \(\017)-9.9(\t\021\215\021\f\016\b\017\021\016 \215\001\235\t\205\211\016\215\021\004\ \))]TJ 36.767 2 Td [(Endoscopic intr)21(aluminal r)21(adiofr)31.1(equency ablation for chr)20.1(onic )]TJ -2.328 -1 Td [(r)21(adiation pr)20(octitis complicated b)10(y r)31(ecurr)31(ent bleeding \(case r)31(epor)-20(t\))]TJ /T1_1 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 42.5896 724.8299 Tm (\023\023\034\226\034\022\031\034)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf 0 Tc 0.525 Tw 10 0 0 10 42.5197 700.4739 Tm (\214\031\004\036\r\026\016 \021\036\030\026\023\017\016 \024\f\021\026\036\ \021\f\016 \022\030\026\036\031\020\024\035\034\027\t\n \022\026\n\027\036\ \n )Tj 0.252 Tw 0 -1.218 TD (\022\024\n\002\017\027\017\030\024\r\026\027\027\024\020\024 \035\036\004\ \036\027\017\016 \023\026\006\017\036\027\021\024\r \f\024 \035\024\022\ \026\004\036)Tj 0 Tw (-)Tj 0.014 Tw T* (\f\021\r\036\027\027\t\n\017 \027\024\r\024\024\002\030\026\024\r\026\027\ \017\016\n\017 \024\030\020\026\027\024\r \n\026\035\024\020\024 \021\026\ \026. )Tj 0.171 Tw T* (\203\036\f\n\024\021\030\016 \027\026)Tj /Span<>> BDC ( )Tj EMC (\023\030\017\n\036\027\036\027\017\036 \f\024\r\030\036\n\036\027\027\024\ \020\024 \024\002\024\030\031\007\024\r\026)Tj 0 Tw (-)Tj 0.307 Tw T* (\027\017\016 \017)Tj /Span<>> BDC ( )Tj EMC (\r\t\f\024\022\024\021\024\004\027\t\b \n\036\021\024\007\017\022, \030\026\ \f\023\030\024\f\021\030\026\027\036\027\027\024\f\021\034 )Tj 0.06 Tw 0 -1.218 TD (\023\024\f\021\035\031\004\036\r\t\b \024\f\035\024\032\027\036\027\017\005\ \024\f\021\026\036\021\f\016 \027\026)Tj /Span<>> BDC ( )Tj EMC (\r\t\f\024\022\024\n \031\030\024\r)Tj 0 Tw (-)Tj 0.142 Tw 0 -1.218 TD [(\027\036 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC [(\007\024\f\021\017\020\026\036\021 )0.5(80% [1]. )0.5(\210\007\027\017\n )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC [(\027\026\017\002\024\035\036\036 )0.5(\004\026\f\021\t\b )]TJ 0.078 Tw T* (\024\f\035\024\032\027\036\027\017\005 \016\r\035\016\036\021\f\016 \b\030\ \024\027\017\004\036\f\022\017\005 \035\031\004\036\r\024\005 \023\030\024\ \022\021\017\021, )Tj 0.077 Tw T* (\030\026\r\017\r\026\033\013\017\005\f\016 \023\030\017\n\036\030\027\024\ \031)Tj /Span<>> BDC ( )Tj EMC (30% \023\026\006\017\036\027\021\024\r. \212\026\027\027\024\036 )Tj 0.278 Tw T* [(\024\f\035\024\032\027\036\027\017\036 \f\031\013\036\f\021\r\036\027\027\ \024 )0.5(\f\027\017\032\026\036\021 \022\026\004\036\f\021\r\024 \032\017\027\017\ )]TJ 0.207 Tw 0 -1.218 TD (\023\026\006\017\036\027\021\024\r \r\f\035\036\007\f\021\r\017\036 \030\ \026\r\017\021\017\016 \030\036\235\030\026\022\021\036\030\027\024\020\ \024 \002\024)Tj 0 Tw (-)Tj -0.002 Tw 0 -1.218 TD [(\035\036\r\024\020\024 )0.5(\f\017\027\007\030\024\n\026 )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC 7.992 0 Td [(\r\t\030\026\032\036\027\027\t\b )0.6(\235\031\027\022\006\017\024\027\026\035\034\027\t\b )0.6(\027\026)]TJ 0 Tw (-)Tj 0.102 Tw -7.992 -1.218 Td (\030\031\001\036\027\017\005 [2,3]. \200\023\036\030\r\t\036 \b\030\024\027\ \017\004\036\f\022\017\005 \035\031\004\036\r\024\005 \023\030\024\022)Tj 0 Tw (-)Tj 0.031 Tw T* [(\021\017\021 \002\t\035 \024\023\017\f\026\027 Ir)-32(v)-16(ing F. \017 \f\024\026\r\021. \r)]TJ /Span<>> BDC ( )Tj EMC (1959 \020\024\007\031, \024\007\027\026\022\024 )Tj 0.086 Tw 0 -1.218 TD (\007\024)Tj /Span<>> BDC ( )Tj EMC 1.313 0 Td [(\027\026\f\021\024\016\013\036\020\024 )0.6(\r\030\036\n\036\027\017 )0.5(\023\030\024\002\035\036\n\026 )0.5(\220\235\235\036\022\021\017\r\027\024\020\024 )0.6(\035\036)]TJ 0 Tw (-)Tj -1.313 -1.218 Td (\004\036\027\017\016 \021\026\022\017\b \023\026\006\017\036\027\021\024\ \r \024\f\021\026\036\021\f\016 \026\022\021\031\026\035\034\027\024\005\ [4].)Tj 0.179 Tw 0 -1.218 TD (\211 85% \023\026\006\017\036\027\021\024\r \f\017\n\023\021\024\n\t \b\030\ \024\027\017\004\036\f\022\024\020\024 \035\031\004\036\r\024\020\024 )Tj -0.057 Tw 0 -1.218 TD (\023\030\024\022\021\017\021\026 \023\024\016\r\035\016\033\021\f\016 \r\ )Tj /Span<>> BDC ( )Tj EMC (\021\036\004\036\027\017\036 \023\036\030\r\t\b \007\r\031\b \035\036\021\ \023\024\f\035\036 )Tj 0.157 Tw T* (\023\030\024\r\036\007\036\027\017\016 \035\031\004\036\r\024\005 \021\036\ \030\026\023\017\017. \025\035\017\027\017\004\036\f\022\026\016 \022\026\ \030\021\017\027\026 )Tj 0.051 Tw 0 -1.218 TD [(\026\002\024\035\036\r\026\027\017\016 )0.5(\b\026\030\026\022\021\036\030\017\031\036\021\f\016, )0.7(\023\030\036\017\n\031\013\036\f\021\r\036\027\027\024, )0.5(\002\024)]TJ 0 Tw (-)Tj 0.162 Tw 0 -1.218 TD (\035\036\r\t\n \f\017\027\007\030\024\n\024\n \r)Tj /Span<>> BDC ( )Tj EMC (\026\027\024\030\036\022\021\026\035\034\027\024\005 \024\002\035\026\f\021\ \017, \007\017\026\030\036)Tj 0 Tw (-)Tj 0.143 Tw 0 -1.218 TD (\036\005 \017)Tj /Span<>> BDC ( )Tj EMC (\030\036\006\017\007\017\r\017\030\031\033\013\017\n\017 \022\030\024\r\024\ \021\036\004\036\027\017\016\n\017 \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\016\n\024\005 )Tj 0.023 Tw T* (\022\017\001\022\017. \200)Tj /Span<>> BDC ( )Tj EMC (\030\016\007\036 \f\035\031\004\026\036\r \b\030\024\027\017\004\036\f\022\ \017\005 \035\031\004\036\r\024\005 \023\030\024\022\021\017\021 )Tj 0.062 Tw T* [(\023\030\017\r\024\007\017\021 )0.5(\022)]TJ /Span<>> BDC ( )Tj EMC [(\235\031\027\022\006\017\024\027\026\035\034\027\t\n )0.6(\027\026\030\031\001\036\027\017\016\n, )0.5(\021\026\022\017\n )0.5(\022\026\022 )]TJ 0.022 Tw T* [(\026\027\026\035\034\027\026\016 )0.5(\017\027\022\024\027\021\017\027\036\027\006\017\016 )0.7(\017)]TJ /Span<>> BDC ( )Tj EMC [(\021\036\027\036\n\t, )0.5(\004\021\024 )0.5(\027\026\004\017\021\036\035\034\027\024 )]TJ 0 Tw T* (\031\b\031\007\001\026\036\021 \022\026\004\036\f\021\r\024 \032\017\027\ \017 \023\026\006\017\036\027\021\024\r [5].)Tj 0.25 Tw T* (\236\031\004\036\027\017\036 \023\026\021\024\020\036\027\036\026 \b\030\ \024\027\017\004\036\f\022\024\020\024 \035\031\004\036\r\024\020\024 \023\ \030\024\022)Tj 0 Tw (-)Tj 0.375 Tw T* (\021\017\021\026 \023\024\022\026\026\035\024, \004\021\024 \022\035\033\ \004\036\r\t\n \235\026\022\021\024\030\024\n \030\026\r\017\021\017\016\ )Tj 0.152 Tw T* (\007\026\027\027\024\020\024 \026\002\024\035\036\r\026\027\017\016 \016\ \r\035\016\036\021\f\016 \n\026\f\f\024\r\026\016 \020\017\002\036\035\034\ \030\026)Tj 0 Tw (-)Tj 0.185 Tw T* [(\007\017\024\004\031\r\f\021\r\017\021\036\035\034\027\t\b )0.5(\022\035\036\021\024\022 \220\023\017\021\036\035\017\016 \023\030\016\n\ \024\005 \022\017\001\022\017, )]TJ -0.013 Tw T* (\017\027\007\031\006\017\030\031\033\013\026\016 \020\017\023\036\030\220\ \022\f\023\030\036\f\f\017\033 \023\030\024\r\024\f\023\026\035\017\021\036\ \035\034\027\t\b )Tj 0.044 Tw T* (\006\017\021\024\022\017\027\024\r \r)Tj /Span<>> BDC ( )Tj EMC (\f\035\017\017\f\021\024\005 \024\002\024\035\024\004\022\036 \017)Tj /Span<>> BDC ( )Tj EMC (\023\024\007\f\035\017\017\f\021\024\005 \024\f)Tj 0 Tw (-)Tj 0.25 Tw T* [(\027\024\r\036. )0.5(\212\026\027\027\t\005 )0.6(\023\030\024\006\036\f\f )0.5(\026\023\031\f\022\026\036\021 )0.5(\022\026\f\022\026\007 )0.5(\023\026\021\024\035\024\020\017)]TJ 0 Tw (-)Tj 0.407 Tw T* (\004\036\f\022\017\b \023\030\024\006\036\f\f\024\r, \r\022\035\033\004\026\ \033\013\017\005 \f\021\024\005\022\031\033 \017\001\036\n\017\033 )Tj 0.577 Tw T* [(\f\035\017\017\f\021\024\005 )0.6(\024\002\024\035\024\004\022\017, )0.5(\023\030\024\020\030\036\f\f\017\030\031\033\013\031\033 )0.6(\026\021\030\024\235\017\033 )]TJ 0.467 Tw T* (\220\023\017\021\036\035\017\016, \030\026\r\017\021\017\036 \235\017\002\ \030\024\026 \017)Tj /Span<>> BDC ( )Tj EMC (\024\002\035\017\021\036\030\017\030\031\033\013\036\020\024 )Tj 0.074 Tw T* (\220\027\007\026\030\021\036\030\017\017\021\026. \224\035\036\007\f\021\ \r\017\036\n \007\026\027\027\t\b \017\n\036\027\036\027\017\005 \f\021\ \026\027\024)Tj 0 Tw (-)Tj -0.028 Tw T* (\r\017\021\f\016 \026\027\024\n\026\035\034\027\t\005 \026\027\020\017\024\ \020\036\027\036 \f)Tj /Span<>> BDC ( )Tj EMC (\235\024\030\n\017\030\024\r\026\027\017\036\n \n\027\024)Tj 0 Tw (-)Tj 0.185 Tw T* (\032\036\f\021\r\036\027\027\t\b \021\036\035\036\026\027\020\017\024\220\ \022\021\026\017\005 \r)Tj /Span<>> BDC ( )Tj EMC (\023\024\007\f\035\017\017\f\021\024\n \f\035\024\036 )Tj 0 Tw T* (\023\030\016\n\024\005 \022\017\001\022\017 [6,7].)Tj 0.326 Tw T* (\212\017\026\020\027\024\f\021\017\022\026 \b\030\024\027\017\004\036\f\022\ \024\020\024 \035\031\004\036\r\024\020\024 \023\030\024\022\021\017\021\ \026, \022\026\022 )Tj 0.062 Tw 0 -1.218 TD (\023\030\026\r\017\035\024, \027\036 \023\030\036\007\f\021\026\r\035\016\ \036\021 \026\021\030\031\007\027\036\027\017\005. \230\026\022, \027\026\ \035\017\004\017\036 )Tj 0.022 Tw 0 -1.218 TD (\r)Tj /Span<>> BDC ( )Tj EMC (\026\027\026\n\027\036\036 \235\026\022\021\026 \023\030\024\r\036\007\036\ \027\017\016 \035\031\004\036\r\024\005 \021\036\030\026\023\017\017 \024\ \030\020\026)Tj 0 Tw (-)Tj 0.049 Tw 0 -1.218 TD [(\027\024\r \n\026\035\024\020\024 )0.5(\021\026\026 \017)]TJ /Span<>> BDC ( )Tj EMC [(\b\026\030\026\022\021\036\030\027\024\005 \022\035\017\027\017\004\036\f\ \022\024\005 )0.5(\f\017\n\023\021\024)]TJ 0 Tw (-)Tj 0.015 Tw T* [(\n\026\021\017\022\017 )0.5(\007\024\f\021\026\021\024\004\027\t )0.6(\007\035\016 )0.5(\024\023\030\036\007\036\035\036\027\017\016 )0.6(\b\026\030\026\022\021\036\030\026 )0.5(\026\002\024)]TJ 0 Tw (-)Tj T* (\035\036\r\026\027\017\016 [3].)Tj 0.097 Tw 0 -1.218 TD (\203\026 \023\030\024\021\016\032\036\027\017\017 \007\035\017\021\036\035\ \034\027\024\020\024 \r\030\036\n\036\027\017 \035\036\004\036\027\017\036\ \023\026\006\017)Tj 0 Tw (-)Tj 0.124 Tw 0 -1.218 TD (\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\b\030\024\027\017\004\036\f\022\017\n \035\031\004\036\r\t\n \023\030\024\ \022\021\017\021\024\n \024\f\027\024\r\t\r\026)Tj 0 Tw (-)Tj 0.382 Tw 0 -1.218 TD [(\035\024\f\034, \023\030\036\017\n\031\013\036\f\021\r\036\027\027\024, \ )0.5(\027\026)]TJ /Span<>> BDC ( )Tj EMC [(\022\024\027\f\036\030\r\026\021\017\r\027\t\b )0.5(\n\036\021\024)]TJ 0 Tw (-)Tj 0.109 Tw 0 -1.218 TD [(\007\026\b, \021\026\022\017\b )0.5(\022\026\022 \022\035\017\n\t \f)]TJ /Span<>> BDC ( )Tj EMC [(\f\031\022\030\026\035\034\235\026\021\024\n, )0.5(\017\027\f\021\017\035\035\016\006\017\017 )]TJ 0.357 Tw 0 -1.218 TD (\235\024\030\n\026\035\017\027\026 \017)Tj /Span<>> BDC ( )Tj EMC (\020\017\023\036\030\002\026\030\017\004\036\f\022\026\016 \024\022\f\017\ \020\036\027\026\006\017\016 [2,3]. )Tj -0.051 Tw 0 -1.218 TD (\215\030\017)Tj /Span<>> BDC ( )Tj EMC (\027\036\220\235\235\036\022\021\017\r\027\024\f\021\017 \007\026\027\027\ \t\b \023\024\007\b\024\007\024\r \023\030\017\n\036\027\016\035\017\f\034\ )Tj 0.105 Tw 23.244 64.543 Td (\030\026\007\017\022\026\035\034\027\t\036 \b\017\030\031\030\020\017\004\ \036\f\022\017\036 \r\n\036\001\026\021\036\035\034\f\021\r\026: \235\024\ \030\n\017)Tj 0 Tw (-)Tj 0.244 Tw T* (\030\024\r\026\027\017\036 \f\021\024\n\t, \030\036\036\022\006\017\016\ \017\035\017 \220\022\f\021\017\030\023\026\006\017\016 \023\030\016\n\024\ \005 )Tj 0.085 Tw T* (\022\017\001\022\017. \210\007\027\026\022\024, \f\024\020\035\026\f\027\ \024 \007\026\027\027\t\n \n\017\030\024\r\024\005 \035\017\021\036\030\026\ \021\031)Tj 0 Tw (-)Tj -0.007 Tw T* (\030\t, \b\017\030\031\030\020\017\004\036\f\022\017\036 \r\n\036\001\026\ \021\036\035\034\f\021\r\026 \f\024\023\030\016\032\036\027\t \f)Tj /Span<>> BDC ( )Tj EMC (\022\030\026\005)Tj 0 Tw (-)Tj 0.03 Tw T* [(\027\036 \r\t\f\024\022\017\n \030\017\f\022\024\n \023\024\f\035\036\024\ \023\036\030\026\006\017\024\027\027\t\b )0.5(\024\f\035\024\032\027\036\027\017\005 )]TJ 0 Tw T* (\(\007\024 80%\) \017)Tj /Span<>> BDC ( )Tj EMC (\035\036\021\026\035\034\027\024\f\021\017 \(\007\024 9%\) [2,3,8].)Tj 0.224 Tw T* (\003\026 \023\024\f\035\036\007\027\036\036 \007\036\f\016\021\017\035\036\ \021\017\036 \220\027\007\024\f\022\024\023\017\004\036\f\022\026\016 \030\ \026\007\017\024)Tj 0 Tw (-)Tj 0.093 Tw 0 -1.218 TD (\004\026\f\021\024\021\027\026\016 \026\002\035\016\006\017\016 \f\021\026\ \035\026 \n\036\021\024\007\024\n \r\t\002\024\030\026 \r)Tj /Span<>> BDC ( )Tj EMC (\035\036\004\036\027\017\017 )Tj 0.232 Tw 0 -1.218 TD (\023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\b\030\024\027\017\004\036\f\022\017\n \035\031\004\036\r\t\n \023\030\024\ \022\021\017\021\024\n \002\035\026)Tj 0 Tw (-)Tj 0.322 Tw T* [(\020\024\007\026\030\016 \r\t\f\024\022\024\005 \220\235\235\036\022\021\ \017\r\027\024\f\021\017, )0.5(\n\017\027\017\n\026\035\034\027\024\005 )0.5(\017\027)]TJ 0 Tw (-)Tj 0.1 Tw T* (\r\026\017\r\027\024\f\021\017, \027\017\022\024\n\031 \030\017\f\022\031\ \024\f\035\024\032\027\036\027\017\005 \(\n\036\027\036\036 5%\), )Tj 0.201 Tw T* [(\022\024\030\024\021\022\017\n )0.5(\f\030\024\022\026\n )0.6(\020\024\f\023\017\021\026\035\017\026\006\017\017 )0.6(\(\024\022\024\035\024 )0.5(48 )0.6(\004\026\f\024\r\) )]TJ 0 Tw 0 -1.218 TD (\017)Tj /Span<>> BDC ( )Tj EMC (\002\t\f\021\030\024\n\031 \r\024\f\f\021\026\027\024\r\035\036\027\017\033\ \023\026\006\017\036\027\021\024\r [9].)Tj /T1_3 1 Tf 0 -2.436 TD (\037\001\007\002\007\006\005\017\004\217\005 \002\020\220\001\200\235\005\ \002\007\005)Tj /T1_2 1 Tf 0.004 Tc 0.266 Tw 0 -1.218 TD (\215\026\006\017\036\027\021\022\026, 74 \035\036\021, \002\t\035\026 \020\ \024\f\023\017\021\026\035\017\017\030\024\r\026\027\026 \r)Tj /Span<>> BDC ( )Tj EMC (\b\017)Tj 0 Tc 0 Tw (-)Tj 0.004 Tc 0.138 Tw 0 -1.218 TD (\030\031\030\020\017\004\036\f\022\024\036 \220\027\007\024\f\022\024\023\ \017\004\036\f\022\024\036 \024\021\007\036\035\036\027\017\036 \f)Tj /Span<>> BDC ( )Tj EMC (\032\026\035\024\002\026)Tj 0 Tc 0 Tw (-)Tj 0.004 Tc 0.208 Tw 0 -1.218 TD (\n\017 \027\026)Tj /Span<>> BDC ( )Tj EMC (\r\t\030\026\032\036\027\027\t\036 \002\024\035\017 \r)Tj /Span<>> BDC ( )Tj EMC [(\026\027\024\030\036\022\021\026\035\034\027\024\005 \024\002\035\026\f\021\ \017)4( )]TJ 0.265 Tw 0 -1.218 TD (\017)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\017\024\007\017\004\036\f\022\017\036 \022\030\024\r\016\027\ \017\f\021\t\036 \r\t\007\036\035\036\027\017\016 \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\016)Tj 0 Tc 0 Tw (-)Tj 0.004 Tc 0.057 Tw 0 -1.218 TD [(\n\024\005 \022\017\001\022\017, )0.5(\023\030\017\r\036\007\001\017\036 \022)]TJ /Span<>> BDC ( )Tj EMC 10.725 0 Td [(\030\026\r\017\021\017\033 )0.5(\026\027\036\n\017\017 \(\031\030\024\r\036\027\034)4.1( )]TJ 0.274 Tw -10.725 -1.218 Td (\020\036\n\024\020\035\024\002\017\027\026 101)Tj /Span<>> BDC ( )Tj EMC (\020/\035\). \236)Tj /Span<>> BDC ( )Tj EMC [(\026\027\026\n\027\036\026 \017\r\036\f\021\027\024, \004\021\024)4( )]TJ 0.241 Tw 0 -1.218 TD (\r)Tj /Span<>> BDC ( )Tj EMC (2015)Tj /Span<>> BDC ( )Tj EMC (\020\024\007\031 \023\026\006\017\036\027\021\022\036 \023\024)Tj /Span<>> BDC ( )Tj EMC [(\n\036\f\021\031 \032\017\021\036\035\034\f\021\r\026 \002\t\035\026)4( )]TJ 0.254 Tw 0 -1.218 TD (\023\030\024\r\036\007\036\027\026 \035\031\004\036\r\026\016 \021\036\030\ \026\023\017\016 \023\024)Tj /Span<>> BDC ( )Tj EMC (\023\024\r\024\007\031 \023\035\024\f\022\024\022\035\036)Tj 0 Tc 0 Tw (-)Tj 0.004 Tc 0.135 Tw 0 -1.218 TD [(\021\024\004\027\024\020\024 \030\026\022\026 \026\027\026\035\034\027\024\ \020\024 \022\026\027\026\035\026, \023\024\f\035\036 \022\024\021\024\030\ \024\005 \002\t\035)4( )]TJ 0.343 Tw T* [(\007\024\f\021\017\020\027\031\021 \023\024\035\027\t\005 \030\036\020\030\ \036\f\f \024\023\031\b\024\035\036\r\024\020\024 \023\030\024\006\036\f\ \f\026.)4( )]TJ 0.128 Tw T* (\200)Tj /Span<>> BDC ( )Tj EMC (2016)Tj /Span<>> BDC ( )Tj EMC (\020\024\007\031 \023\026\006\017\036\027\021\022\036 \r\t\023\024\035\027\ \036\027\026 \021\024\021\026\035\034\027\026\016 \020\017\f\021\036)Tj 0 Tc 0 Tw (-)Tj 0.004 Tc 0.375 Tw T* [(\030\220\022\021\024\n\017\016 )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC 5.544 0 Td (\002\017\035\026\021\036\030\026\035\034\027\024\005 \f\026\035\034\023\017\ \027\020\024\024\235\024\030\220\022\021\024\n\017)Tj 0 Tc 0 Tw (-)Tj 0.004 Tc 0.21 Tw -5.544 -1.218 Td (\036\005 \f)Tj /Span<>> BDC ( )Tj EMC [(\023\024\f\035\036\007\031\033\013\036\005 \026\007\255\033\r\026\027\021\ \027\024\005 \035\031\004\036\r\024\005 \021\036\030\026\023\017\036\005\ )4( )]TJ 0.067 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC (\024\002\035\026\f\021\034 \n\026\035\024\020\024 \021\026\026 \023\024\ )Tj /Span<>> BDC ( )Tj EMC [(\023\024\r\024\007\031 \035\024\022\026\004\036\f\021\r\036\027\027\024\ \020\024)4( )]TJ 0.056 Tw T* [(\027\024\r\024\024\002\030\026\024\r\026\027\017\016 \n\026\021\022\017\ . \210\007\027\026\022\024 \004\036\030\036 \023\024\035\021\024\030\026\ \020\024\007\026)3.9( )]TJ 0.044 Tw T* [(\023\024\f\035\036 \026\r\036\030\001\036\027\017\016 \035\031\004\036\r\ \024\005 \021\036\030\026\023\017\017 \023\026\006\017\036\027\021\022\026\ \f\021\026\035\026)4( )]TJ 0.062 Tw T* [(\024\021\n\036\004\026\021\034 )0.5(\r\t\030\026\032\036\027\027\t\036 )0.5(\002\024\035\036\r\t\036 )0.5(\024\013\031\013\036\027\017\016 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 18.83 0 Td (\026\027\024\030\036\022)Tj 0 Tc 0 Tw (-)Tj 0.004 Tc 0.195 Tw -18.83 -1.218 Td (\021\026\035\034\027\024\005 \024\002\035\026\f\021\017, \r)Tj /Span<>> BDC ( )Tj EMC (\f\r\016\017 \f)Tj /Span<>> BDC ( )Tj EMC (\004\036\n \024\002\030\026\021\017\035\026\f\034 \022)Tj /Span<>> BDC ( )Tj EMC (\023\030\024)Tj 0 Tc 0 Tw (-)Tj 0.004 Tc 0.148 Tw T* (\022\021\024\035\024\020\031 \023\024)Tj /Span<>> BDC ( )Tj EMC [(\n\036\f\021\031 )0.5(\032\017\021\036\035\034\f\021\r\026. \207\t\035\026 \027\026\027\026\004\ \036\027\026 \022\024\027)]TJ 0 Tc 0 Tw (-)Tj 0.004 Tc 0.127 Tw T* (\f\036\030\r\026\021\017\r\027\026\016 \021\036\030\026\023\017\016, \024\ \007\027\026\022\024 \027\026)Tj /Span<>> BDC ( )Tj EMC [(\235\024\027\036 \023\030\024\r\024\007\017\n\024\020\024)4( )]TJ -0.038 Tw T* [(\035\036\004\036\027\017\016 \027\026\004\017\n\024\020\024 \022\035\017\ \027\017\004\036\f\022\024\020\024 \031\035\031\004\001\036\027\017\016 \ \027\036 \002\t\035\024)4( )]TJ 0.108 Tw T* (\024\021\n\036\004\036\027\024. \215\024\032\036 \023\026\006\017\036\027\ \021\022\026 \f\021\026\035\026 \024\021\n\036\004\026\021\034 \023\024\016\ \r\035\036)Tj 0 Tc 0 Tw (-)Tj 0.004 Tc -0.014 Tw T* (\027\017\036 \022\030\024\r\016\027\017\f\021\t\b \r\t\007\036\035\036\027\ \017\005 \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\016\n\024\005 \022\017\001\022\017, \r)Tj /Span<>> BDC ( )Tj EMC (\f\r\016)Tj 0 Tc 0 Tw (-)Tj 0.004 Tc -0.037 Tw T* (\017 \f)Tj /Span<>> BDC ( )Tj EMC (\004\036\n \023\026\006\017\036\027\021\022\026 \002\t\035\026 \020\024\f\ \023\017\021\026\035\017\017\030\024\r\026\027\026 \023\024)Tj /Span<>> BDC ( )Tj EMC [(\n\036\f\021\031)4( )]TJ 0.031 Tw T* (\032\017\021\036\035\034\f\021\r\026. \215\030\017)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\r\036\007\036\027\017\017 \030\036\022\021\024\f\022\024\023\ \017\017 \002\t\035 \007\017\026\020)Tj 0 Tc 0 Tw (-)Tj 0.004 Tc 0.056 Tw T* (\027\024\f\021\017\030\024\r\026\027 \b\030\024\027\017\004\036\f\022\017\ \005 \035\031\004\036\r\024\005 \023\030\024\022\021\017\021 \f)Tj /Span<>> BDC ( )Tj EMC (\027\026\035\017\004\017)Tj 0 Tc 0 Tw (-)Tj 0.004 Tc 0.032 Tw T* (\036\n \n\027\024\032\036\f\021\r\036\027\027\t\b \021\036\035\036\026\027\ \020\017\024\220\022\021\026\017\005. \200)Tj /Span<>> BDC ( )Tj EMC [(\007\026\035\034\027\036\005\001\036\n)3.9( )]TJ 0.28 Tw T* [(\027\036\024\007\027\024\022\030\026\021\027\024 )0.5(\023\030\036\007\023\030\017\027\017\n\026\035\017\f\034 )0.5(\023\024\023\t\021\022\017 )0.5(\220\027\007\024\f\022\024)]TJ 0 Tc 0 Tw (-)Tj 0.004 Tc 0.258 Tw 0 -1.218 TD (\023\017\004\036\f\022\024\020\024 \020\036\n\024\f\021\026\026 \f)Tj /Span<>> BDC ( )Tj EMC [(\017\f\023\024\035\034\024\r\026\027\017\036\n \030\026\035\017\004\027\ \t\b)4( )]TJ 0.219 Tw 0 -1.218 TD [(\n\036\021\024\007\024\r: \220\035\036\022\021\030\024\b\017\030\031\030\ \020\017\004\036\f\022\024\005 \022\024\026\020\031\035\016\006\017\017 \ \024\004\026\020\024\r)4( )]TJ 0.197 Tw 0 -1.218 TD (\021\036\035\036\026\027\020\017\024\220\022\021\026\017\005 \017)Tj /Span<>> BDC ( )Tj EMC (\007\r\031\022\030\026\021\027\024\020\024 \023\030\017\n\036\027\036\027\ \017\016 \026\030\020\024)Tj 0 Tc 0 Tw (-)Tj 0.004 Tc 0.014 Tw T* [(\027\024\023\035\026\n\036\027\027\024\005 \022\024\026\020\031\035\016\ \006\017\017. \210\007\027\026\022\024 \007\026\027\027\t\036 \n\036\021\ \024\007\017\022\017)4( )]TJ 0.211 Tw T* (\027\036 \024\002\036\f\023\036\004\017\035\017 \032\036\035\026\036\n\024\ \020\024 \030\036\031\035\034\021\026\021\026, \031)Tj /Span<>> BDC ( )Tj EMC [(\023\026\006\017\036\027\021\022\017)4( )]TJ 0.319 Tw 0 -1.218 TD (\f\024\b\030\026\027\016\035\017\f\034 \023\036\030\017\024\007\017\004\036\ \f\022\017\036 \022\030\024\r\024\021\036\004\036\027\017\016, \023\030\017\ \r\024)Tj 0 Tc 0 Tw (-)Tj 0.004 Tc 0.025 Tw 0 -1.218 TD (\007\016\013\017\036 \022)Tj /Span<>> BDC ( )Tj EMC (\030\026\r\017\021\017\033 \026\027\036\n\017\017. \200)Tj /Span<>> BDC ( )Tj EMC (\f\r\016\017 \f)Tj /Span<>> BDC ( )Tj EMC (\027\036\220\235\235\036\022\021\017\r\027\024)Tj 0 Tc 0 Tw (-)Tj 0.004 Tc 0.147 Tw 0 -1.218 TD (\f\021\034\033 \023\030\024\r\036\007\036\027\027\024\020\024 \030\026\027\ \036\036 \022\024\027\f\036\030\r\026\021\017\r\027\024\020\024 \017)Tj /Span<>> BDC ( )Tj EMC (\220\027\007\024)Tj 0 Tc 0 Tw (-)Tj 0.004 Tc 0.137 Tw 0 -1.218 TD [(\f\022\024\023\017\004\036\f\022\024\020\024 \035\036\004\036\027\017\016\ \023\026\006\017\036\027\021\022\036 \002\t\035\024 \023\030\036\007\035\ \024\032\036\027\024)4( )]TJ 0.067 Tw 0 -1.218 TD (\b\017\030\031\030\020\017\004\036\f\022\024\036 \r\n\036\001\026\021\036\ \035\034\f\021\r\024 \r)Tj /Span<>> BDC ( )Tj EMC (\024\002\255\201\n\036 \024\002\f\021\030\031\022\021\017\r)Tj 0 Tc 0 Tw (-)Tj 0.004 Tc 0.499 Tw 0 -1.218 TD (\027\024\005 \030\036\036\022\006\017\017 \023\030\016\n\024\005 \022\017\ \001\022\017 \f)Tj /Span<>> BDC ( )Tj EMC [(\235\024\030\n\017\030\024\r\026\027\017\036\n)4( )]TJ 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 0 Tc 0 Tw 7.5 0 0 7.5 42.5197 759.8869 Tm 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l S Q [0 2.997]0 d q 1 0 0 1 74.3631 402.8025 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 71.3661 402.8025 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q [0 2.997]0 d q 1 0 0 1 74.3631 201.1521 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 71.3661 201.1521 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q [0 2.997]0 d q 1 0 0 1 74.3631 163.9443 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 71.3661 163.9443 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q 0 j 0 J q 1 0 0 1 70.8661 112.7098 cm 0 0 m 453.543 0 l S Q BT 0 0 0 1 k /T1_0 1 Tf 10 0 0 10 70.8661 724.8299 Tm (https://doi.org/10.33878/2073-7556-2025-24-4-120-124)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0.023 Tw 19 0 0 19 88.8344 695.3259 Tm [(\225\215\211\025\b\017)10(\025\222\021\f\016\b\017\001\004 \r\215\200)-20(\026\201\021\222\201\025\b\r\016\026\215\001\004 \201\001\211\021\025\f\001\ \b)-9.9(\026)11(\025\026\215\001\004 )]TJ -0.223 -1.105 Td [(\001\235\t\004\212\021\004 \r\022)-23.2(\t\016\f\016\215\021\021 \222\001\212\021\016\215\026\017\021 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complicated )]TJ 1.314 -1.167 Td [(b)10(y r)31(ecurr)31.1(ent bleeding \(case r)31(epor)-20(t\))]TJ 0 0 0 1 k /GS1 gs 14 0 0 14 70.8661 312.9639 Tm [(Y)40(ur)-31(y\022)-23.2(G.\022)-23.3(Stark)11(ov)21(, A)20(y)10(ubkhan\022)-23.2(I.\022)-23.3(V)31(agapov)21(, Rodion\022)-23.2(D.\022)-23.3(Z)21(amolodchik)11.1(ov)20.9(, )]TJ 0 Tw 0 -1.143 TD [(Seda\022)-23.3(V)62(.\022)-23.2(D)21(zhantukhanov)10(a)]TJ 0.023 Tw 10 0 0 10 70.8661 279.2946 Tm [(Vishne)11.1(v)9.9(sky National Medical Resear)31.1(ch Center of\022)-23.2(Sur)31(ger)-31(y \(B. Serpukh)11(ov)10(skay)21(a\022)-23.2(st., 2)46(7)127(, Moscow)22(, 1)212(1)137.9(77)35.1(99)35(7)127(, Russia\))]TJ /T1_0 1 Tf 0.077 Tw 9 0 0 9 119.0551 260.7906 Tm [(A 74-year)23.1(-old female patient under)-31.9(w)12(ent endoscopic treatment for chronic radiation p)45.9(roctitis. W)30(e successfully per)]TJ 0 Tw 44.743 0 Td (-)Tj 0.071 Tw -44.743 -1.111 Td [(for)-14(med endoscopic radiofreq)14.1(uency ablation. The)]TJ /Span<>> BDC ( )Tj EMC [(inter)-42(v)13(ention per)-33.9(for)-14(med allow)12(ed no)13(t only to)]TJ /Span<>> BDC ( )Tj EMC [(im)15.9(p)46(rov)13(e the)]TJ /Span<>> BDC ( )Tj EMC [(patient\237)37(s )]TJ 0.023 Tw 0 -1.111 TD [(q)14(uality of)]TJ /Span<>> BDC ( )Tj EMC (life, but also to)Tj /Span<>> BDC ( )Tj EMC [(av)13(oid high v)13(olume surg)12(er)-43(y)32(.)]TJ /T1_2 1 Tf 0.01 Tc -0.01 Tw 8 0 0 8 70.906 225.5214 Tm [(KEYW)22(ORDS:)]TJ /T1_0 1 Tf 0 Tc 0.023 Tw 4.948 0 Td [( chronic radiation p)46(roctitis, radiofreq)14(uency ablation, radio)13(therap)12.1(y com)16(plications, endoscopic surg)12(er)-43(y)]TJ /T1_2 1 Tf 0.01 Tc 0.018 Tw -4.948 -1.909 Td [(C)19(ONFL)-33(ICT)5( OF)]TJ /Span<>> BDC 5.312 0 Td ( )Tj EMC [(INTE)25(REST)61.9(:)]TJ /T1_0 1 Tf 0 Tc 0.023 Tw 4.559 0 Td ( the)Tj /Span<>> BDC ( )Tj EMC [(authors declare no conf)-22(lict of)]TJ /Span<>> BDC ( )Tj EMC (interest)Tj /T1_2 1 Tf 0.037 Tc -0.036 Tw -9.871 -2.617 Td [(F)3.2(O)-4.6(R)8.7( C)-17.4(I)-15.6(T)45.4(A)37.5(T)-24.4(I)-1.3(ON:)]TJ /T1_3 1 Tf 0.033 Tc -0.037 Tw 6.409 0 Td [( S)6.8(t)-26.8(ar)-20.7(k)6.3(ov)]TJ /Span<>> BDC 3.47 0 Td ( )Tj EMC [(Y)22.6(u)1(.)25.1(G)-1.6(.)-13.5(,)9.7( V)13.8(a)-0.8(g)1.9(a)1.2(p)-12.2(ov)]TJ /Span<>> BDC 6.516 0 Td ( )Tj EMC [(A)-13(.I.)-13.5(,)9.7( Z)-24(am)-2.4(o)-5.6(l)-10.8(o)-10.4(d)0.7(ch)-4(i)3.4(k)6.3(ov)9.8( R)-11.4(.)11.4(D)26.4(.)-13.5(,)9.7( D)-6.8(z)-2.5(h)1.7(a)2.4(n)-7.3(t)-12.3(uk)-6.8(h)1.7(a)2.5(n)-1.9(ov)-18.4(a)]TJ /Span<>> BDC 18.487 0 Td ( )Tj EMC [(S.)50.6(V)49.7(.)9.8( E)9.1(n)-4.5(d)-1.1(o)-5.8(s)-7.7(c)3.5(o)1.8(p)-8.7(i)5.1(c)9.7( i)6.8(n)-7.3(t)-20.8(r)-20.7(a)-1.4(l)-13.3(u)3(m)-4.5(i)6.8(n)2.2(a)-1.4(l)9.8( r)-20.8(a)-3(d)-5.8(i)3.2(o)-2.1(f)-37.6(r)-9(e)-11.4(q)-6(u)-2.5(e)-1.5(nc)-32.4(y)9.8( a)-8.2(b)-8.2(l)-27.8(a)]TJ 0 Tc 0 Tw 21.454 0 Td (-)Tj 0.019 Tc -0.035 Tw -56.341 -1.2 Td [(t)-46(i)-6.5(o)-9(n f)-25(o)-11.6(r c)-10(h)-6.4(r)-15.6(o)-8.9(n)-13.8(i)-4.8(c r)-30.6(a)-12.7(d)-15.6(i)-4.9(a)-17.9(t)-46(i)-6.6(o)-9(n p)-13.4(r)-15.6(o)-16.6(c)-41.3(t)-45.9(i)-15.6(t)-46(i)-7.1(s c)-6.3(o)-9(m)-5(p)-19.8(l)-16.5(i)-4.8(c)-21.2(a)-18(t)-24.5(e)-20.8(d b)-19.7(y r)-18.9(e)-18.9(c)-11.8(u)-7.4(r)-40.3(r)-18.9(e)-11.2(n)-17.1(t b)-18(l)-23.4(e)-25(e)-20.8(d)-15.6(i)-2.9(n)-11.7(g \()43.7(c)-21.3(a)-26.3(s)-22.7(e r)-18.9(e)-10.4(p)-22.1(o)-11.6(r)-59.5(t)12.4(\))10.6(. )]TJ /T1_0 1 Tf 0.025 Tc -0.025 Tw [(K)10.1(o)-3.8(lo)-3.9(p)-1.4(r)-0.6(ok)-23(t)-1.5(o)-3.9(lo)-7(g)-17(i)2.9(a)2(.)]TJ /T1_3 1 Tf 0.019 Tc -0.035 Tw 42.984 0 Td [( 2)-8.7(0)-3.6(2)-1.2(5)23.6(;)10(2)9(4)-13.3(\()40.4(4)30.5(\))14.7(:)21.2(12)-8.7(0)-32.6(\226)51(12)9(4)-0.8(. \()-0.7(i)-2.9(n R)-6.3(u)-21.7(s)-22.1(s)-15.2(.)43.4(\))10.6(.)19.1( )]TJ 0.023 Tc -0.023 Tw -42.984 -1.2 Td [(h)-17.2(t)-49.4(t)-29.4(p)-18.7(s)-8(:)1.9(/)84.7(/)36.4(d)-11.1(o)-12.5(i.)2.7(o)-11.8(r)-16.7(g)-22.8(/)11.2(1)14(0)6.5(.)-5.6(3)7.9(3)-15.9(8)1.3(7)4.6(8/)7.9(2)-8.9(0)9.3(7)-1.9(3)-13.3(-)41.2(7)10.7(55)-8.9(6)-26.7(-)9.7(2)-8.9(0)-3.8(2)-1.4(5)-23.5(-)9.7(2)8.8(4)-28.5(-)-30.3(4)-28.5(-)55.1(12)-8.9(0)-33.4(-)55.1(12)8.8(4)]TJ /T1_2 1 Tf 0.01 Tc 0.148 Tw 0.005 -2.617 Td [(\021\024\027\030\026)5( \024\033\023)5.1( \t\030\027\030\t\032\026\037\032:)]TJ /T1_0 1 Tf 0 Tc 0.153 Tw 10.836 0 Td ( \037\013\037\f\034\036 \205\026\025\002\037\020 \200\b\033\022\024\034\ \036\022\005, \216\223\210\215 \253\217\214\200\221 \002\022\033\023\033\ \013\022\022 \022\006. \205..)Tj /Span<>> BDC ( )Tj EMC (\022\001\020\016\036\024\021\034\013\034\273 \214\022\020\031\b\033\037\ \036\037 \213\034\024\024\022\022, \023\027.)Tj /Span<>> BDC ( )Tj EMC (\210\034\027\003\001\037\030 )Tj 0.023 Tw -10.841 -1.2 Td (\207\016\033\f\023\002\034\036\024\021\037\030, \b.)Tj /Span<>> BDC ( )Tj EMC (27, \214\034\024\021\036\037, 117997, \213\034\024\024\022\030; \202\016\ \027.:)Tj /Span<>> BDC ( )Tj EMC (+7-964-067-84-00, E-mail: vagapov9494@mail.ru)Tj /T1_2 1 Tf 0.01 Tc 0.074 Tw 0.005 -1.2 Td [(ADDRESS)5( F)13(OR)5( C)19(ORRESPONDEN)23(CE:)]TJ /T1_0 1 Tf 0 Tc 0.079 Tw 14.162 0 Td [( V)33(ag)12(apov A.I., Vishnevsky N)18(ational Medical R)21(esearch Center of)]TJ /Span<>> BDC ( )Tj EMC [(Surg)12(er)-43(y \(B. Ser)-18(pukhovsk)11.1(aya st., 27, Moscow)52.1(, )]TJ 0.023 Tw -14.167 -1.2 Td [(1177997, R)22(ussia;)]TJ /Span<>> BDC ( )Tj EMC [(+7-964-067-84-00, E-mail: v)16(ag)12(apov9494@mail.ru)]TJ 0 Tw 0 -2.438 TD (\n\037\035\037 \f\034\024\035\023\f\027\016\020\022\030)Tj /Span<>> BDC ( )Tj EMC (\227 28.07.2025)Tj /Span<>> BDC ( )Tj EMC 19.488 0 Td (\t\034\024\027\016 \b\034\033\037\025\034\035\021\022)Tj /Span<>> BDC ( )Tj EMC (\227 27.08.2025)Tj /Span<>> BDC ( )Tj EMC 18.78 0 Td (\t\033\022\020\030\035\034 \021)Tj /Span<>> BDC ( )Tj EMC (\f\023\025\027\022\021\037\007\022\022)Tj /Span<>> BDC ( )Tj EMC (\227 10.11.2025)Tj ( )Tj -38.268 -1.375 Td (Received)Tj /Span<>> BDC ( )Tj EMC (\227 28.07.2025)Tj /Span<>> BDC ( )Tj EMC 19.488 0 Td (Revised)Tj /Span<>> BDC ( )Tj EMC (\227 27.08.2025)Tj /Span<>> BDC ( )Tj EMC 18.78 0 Td (Accepted for publication)Tj /Span<>> BDC ( )Tj EMC (\227 10.11.2025)Tj ET 1 0.68 0 0.12 k /GS0 gs q 1 0 0 1 70.8661 568.1533 cm 0 0 m 0 0 l 0 -11.339 l 42.52 -11.339 l 42.52 0 l h f Q BT 0 0 0 0 k /T1_2 1 Tf 9 0 0 9 76.0071 559.226 Tm (\027\030\013\016\n\030)Tj ET 1 0.68 0 0.12 k q 1 0 0 1 70.8661 269.2949 cm 0 0 m 0 0 l 0 -11.339 l 42.52 -11.339 l 42.52 0 l h f Q BT 0 0 0 0 k /T1_2 1 Tf 9 0 0 9 73.5728 260.3676 Tm (ABSTRACT)Tj ET q 0 0 566.929 793.701 re W n BT 1 0.68 0 0.12 k /T1_4 1 Tf 0.01 Tc 0.018 Tw 14 0 0 14 42.5896 837.3533 Tm [(\212\b\006\t\006\223\207\017\212\006\207)5( \t\037\210)21.1(\b\204\216\207\t\006\231)]TJ /T1_1 1 Tf 0 -1.605 TD [(C)10(A)20(SE)5( REPORT)]TJ ET Q BT 1 0.68 0 0.12 k /T1_1 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\037\035\030\217\030\224\003\013\037\030\003 \217\n\206\035\204)15(\240\003\217\030\027)]TJ 54.711 0 Td [(C)10(A)20(SE REPORT)]TJ -54.711 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 2)69(4, \023\0224, 202)23(5)]TJ 43.013 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 2)69(4, \023\0224, 202)23(5)]TJ /T1_5 1 Tf 25 0 0 25 20.7653 56.0378 Tm (120)Tj ET q 0 g 0 G /Fm1 Do Q 0 0 0 0 k 396.85 725.67 59.155 11.338 re f /PlacedPDF /MC0 BDC q 397.481 736.808 m 397.242 736.808 397.049 736.616 397.049 736.376 c 397.049 736.376 l 397.049 726.285 l 397.049 726.045 397.242 725.853 397.481 725.853 c 397.481 725.853 l 455.382 725.853 l 455.62 725.853 455.815 726.045 455.815 726.285 c 455.815 726.285 l 455.815 736.376 l 455.815 736.616 455.62 736.808 455.382 736.808 c 455.382 736.808 l h W n q 0 g -0.0000005 -10.9560913 -10.9560913 0.0000005 426.4320445 736.8086309 cm BX /Sh0 sh EX Q Q q 396.85 725.67 59.155 11.337 re W n 0 0 0 0.84 k q 1 0 0 1 413.5634 732.4249 cm 0 0 m -0.025 0.1 -0.063 0.196 -0.112 0.287 c -0.157 0.374 -0.218 0.451 -0.292 0.515 c -0.37 0.582 -0.46 0.632 -0.558 0.664 c -0.669 0.701 -0.786 0.719 -0.903 0.717 c -1.076 0.722 -1.247 0.681 -1.4 0.6 c -1.536 0.526 -1.652 0.42 -1.74 0.292 c -1.83 0.158 -1.895 0.008 -1.934 -0.149 c -2.018 -0.48 -2.018 -0.827 -1.934 -1.158 c -1.896 -1.316 -1.83 -1.466 -1.74 -1.602 c -1.653 -1.731 -1.536 -1.837 -1.4 -1.912 c -1.247 -1.993 -1.076 -2.033 -0.903 -2.029 c -0.774 -2.032 -0.647 -2.006 -0.528 -1.955 c -0.427 -1.906 -0.337 -1.837 -0.263 -1.753 c -0.185 -1.665 -0.124 -1.563 -0.082 -1.453 c -0.034 -1.338 0 -1.218 0.019 -1.094 c 0.635 -1.094 l 0.624 -1.297 0.578 -1.497 0.497 -1.684 c 0.421 -1.857 0.312 -2.015 0.175 -2.146 c 0.039 -2.277 -0.123 -2.379 -0.3 -2.446 c -0.492 -2.519 -0.695 -2.555 -0.9 -2.552 c -1.15 -2.557 -1.397 -2.506 -1.625 -2.404 c -1.829 -2.307 -2.01 -2.169 -2.157 -1.997 c -2.308 -1.821 -2.423 -1.617 -2.497 -1.397 c -2.655 -0.924 -2.655 -0.412 -2.497 0.061 c -2.423 0.281 -2.307 0.485 -2.157 0.661 c -2.01 0.833 -1.829 0.973 -1.625 1.07 c -1.398 1.174 -1.15 1.226 -0.9 1.222 c -0.707 1.223 -0.515 1.196 -0.329 1.14 c -0.159 1.088 0.001 1.006 0.144 0.898 c 0.278 0.793 0.39 0.662 0.473 0.513 c 0.562 0.349 0.615 0.167 0.629 -0.019 c 0 -0.019 l 0 0 l f Q q 1 0 0 1 414.6923 733.5723 cm 0 0 m 0.584 0 l 0.584 -1.328 l 0.662 -1.204 0.771 -1.103 0.9 -1.033 c 1.046 -0.951 1.213 -0.91 1.381 -0.914 c 1.627 -0.9 1.869 -0.979 2.058 -1.137 c 2.234 -1.312 2.325 -1.556 2.305 -1.803 c 2.305 -3.596 l 1.716 -3.596 l 1.716 -1.976 l 1.724 -1.817 1.678 -1.66 1.585 -1.53 c 1.486 -1.43 1.347 -1.379 1.206 -1.392 c 1.114 -1.39 1.024 -1.408 0.94 -1.445 c 0.865 -1.479 0.798 -1.529 0.744 -1.591 c 0.687 -1.656 0.645 -1.73 0.616 -1.812 c 0.586 -1.896 0.571 -1.986 0.571 -2.077 c 0.571 -3.615 l 0 -3.615 l 0 0 l f Q q 1 0 0 1 418.0385 731.1235 cm 0 0 m 0 -0.099 0.014 -0.198 0.043 -0.292 c 0.069 -0.382 0.112 -0.466 0.17 -0.54 c 0.229 -0.611 0.304 -0.669 0.388 -0.709 c 0.486 -0.754 0.594 -0.776 0.702 -0.773 c 0.845 -0.78 0.987 -0.742 1.108 -0.664 c 1.217 -0.582 1.296 -0.468 1.336 -0.337 c 1.881 -0.337 l 1.827 -0.603 1.675 -0.838 1.456 -0.996 c 1.35 -1.073 1.231 -1.131 1.105 -1.169 c 0.971 -1.208 0.831 -1.229 0.691 -1.227 c 0.509 -1.227 0.328 -1.191 0.16 -1.121 c 0.007 -1.063 -0.13 -0.972 -0.244 -0.855 c -0.356 -0.73 -0.44 -0.583 -0.491 -0.422 c -0.548 -0.243 -0.576 -0.056 -0.574 0.133 c -0.575 0.313 -0.545 0.493 -0.486 0.664 c -0.426 0.826 -0.335 0.974 -0.22 1.102 c 0.004 1.375 0.338 1.534 0.691 1.535 c 0.883 1.539 1.072 1.495 1.243 1.408 c 1.402 1.326 1.541 1.209 1.649 1.067 c 1.759 0.922 1.838 0.757 1.883 0.582 c 1.932 0.396 1.945 0.203 1.92 0.013 c 0 0.013 l 0 0 l 1.342 0.377 m 1.335 0.468 1.315 0.557 1.283 0.643 c 1.253 0.724 1.209 0.798 1.153 0.863 c 1.097 0.922 1.03 0.97 0.957 1.004 c 0.874 1.043 0.783 1.063 0.691 1.062 c 0.6 1.062 0.509 1.044 0.425 1.009 c 0.345 0.976 0.273 0.926 0.213 0.863 c 0.153 0.799 0.105 0.724 0.072 0.643 c 0.037 0.559 0.017 0.468 0.014 0.377 c 1.355 0.377 l h f Q q 1 0 0 1 422.1581 731.7051 cm 0 0 m -0.012 0.144 -0.082 0.276 -0.194 0.366 c -0.31 0.452 -0.451 0.495 -0.595 0.489 c -0.675 0.488 -0.755 0.476 -0.831 0.452 c -0.918 0.424 -0.998 0.375 -1.062 0.311 c -1.142 0.229 -1.202 0.131 -1.24 0.024 c -1.29 -0.132 -1.312 -0.296 -1.304 -0.459 c -1.304 -0.569 -1.292 -0.677 -1.267 -0.784 c -1.244 -0.885 -1.202 -0.983 -1.145 -1.07 c -1.09 -1.154 -1.016 -1.224 -0.93 -1.275 c -0.833 -1.33 -0.722 -1.356 -0.611 -1.352 c -0.457 -1.357 -0.307 -1.301 -0.194 -1.195 c -0.078 -1.077 -0.005 -0.922 0.011 -0.757 c 0.587 -0.757 l 0.556 -1.055 0.419 -1.332 0.202 -1.538 c -0.022 -1.721 -0.306 -1.815 -0.595 -1.803 c -0.777 -1.806 -0.958 -1.771 -1.126 -1.7 c -1.293 -1.642 -1.445 -1.547 -1.57 -1.421 c -1.68 -1.297 -1.763 -1.151 -1.814 -0.993 c -1.87 -0.822 -1.898 -0.643 -1.896 -0.462 c -1.898 -0.276 -1.871 -0.091 -1.817 0.087 c -1.766 0.252 -1.682 0.405 -1.57 0.537 c -1.459 0.664 -1.323 0.766 -1.168 0.834 c -0.991 0.914 -0.798 0.955 -0.603 0.954 c -0.457 0.954 -0.311 0.935 -0.17 0.895 c -0.039 0.858 0.084 0.799 0.194 0.72 c 0.302 0.643 0.393 0.543 0.459 0.428 c 0.531 0.298 0.572 0.155 0.582 0.008 c 0 0.008 l 0 0 l f Q q 1 0 0 1 423.2177 733.5723 cm 0 0 m 0.577 0 l 0.577 -2.048 l 1.615 -0.985 l 2.322 -0.985 l 1.323 -1.944 l 2.417 -3.604 l 1.716 -3.604 l 0.919 -2.337 l 0.577 -2.669 l 0.577 -3.604 l 0 -3.604 l h f Q q 1 0 0 1 427.0585 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( )Tj EMC (\002\030\033\001\027\024-\023\030\024\n\036\032\027\024\f\021\027\031\033\ \220\022\f\021\017\030\023\026\006\017\033 )Tj 0.286 Tw T* (\(\207\215\225\) \r)Tj /Span<>> BDC ( )Tj EMC (\026\r\017\f\017\n\024\f\021\017 \024\021 \035\024\022\026\035\017\026\ \006\017\017, \030\026\f\023\030\024\f\021\030\026)Tj 0 Tw (-)Tj 0.242 Tw T* [(\027\036\027\027\024\f\021\017 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC [(\f\021\026\007\017\017 )0.5(\024\023\031\b\024\035\017. \203\026\002\035\033\007\036\027\017\036 \026\ )]TJ /Span<>> BDC ( )Tj EMC 19.768 0 Td (\023\026\006\017)Tj 0 Tw (-)Tj 0.135 Tw -19.768 -1.218 Td (\036\027\021\026\n\017 \023\030\024\r\024\007\017\035\024\f\034 \030\036\ \020\031\035\016\030\027\024 \022\026\032\007\t\036 \021\030\017 \n\036\f\ \016\006\026. )Tj 0.105 Tw T* (\203\026\002\035\033\007\036\027\017\036 \023\030\024\007\024\035\032\026\ \035\024\f\034 \007\024)Tj /Span<>> BDC ( )Tj EMC (\007\r\031\b \035\036\021 \007\035\016 \r\t\016\r\035\036)Tj 0 Tw (-)Tj 0 -1.218 TD (\027\017\016 \030\036\006\017\007\017\r\024\r \017)Tj /Span<>> BDC ( )Tj EMC (\024\f\035\024\032\027\036\027\017\005 \022\017\001\036\004\027\024\005 \ \f\021\024\n\t)Tj /Span<>> BDC ( )Tj EMC ([7].)Tj 0.158 Tw 0 -1.218 TD (\236\031\004\026\036\n\t\n\017 \023\026\030\026\n\036\021\030\026\n\017\ \002\t\035\017 \f\030\036\007\027\016\016 \023\030\024\007\024\035\032\017\ )Tj 0 Tw (-)Tj 0.237 Tw 0 -1.218 TD [(\021\036\035\034\027\024\f\021\034 \024\023\036\030\026\006\017\017, )0.5(\022\030\024\r\024\023\024\021\036\030\016 \017)]TJ /Span<>> BDC ( )Tj EMC (\023\030\024\007\024\035\032\017\021\036\035\034)Tj 0 Tw (-)Tj 0.259 Tw T* (\027\024\f\021\034 \023\030\036\002\t\r\026\027\017\016 \r)Tj /Span<>> BDC ( )Tj EMC (\f\021\026\006\017\024\027\026\030\036. \206\030\031\023\023\026 \f)Tj /Span<>> BDC ( )Tj EMC (\031\035\034\021\030\026)Tj 0 Tw (-)Tj 0.103 Tw T* [(\r\031\022\024\r\t\n )0.5(\f\022\026\035\034\023\036\035\036\n )0.6(\017\n\036\035\026 )0.5(\002\024\035\036\036 )0.5(\027\017\022\031\033 )0.6(\f\030\036\007\027\033\033 )]TJ 0.618 Tw T* (\023\030\024\007\024\035\032\017\021\036\035\034\027\024\f\021\034 \024\023\ \036\030\026\006\017\017, \004\021\024 \f\021\026\021\017\f\021\017\004\036\ \f\022\017 )Tj 0.26 Tw T* [(\027\026\004\017\n\024. )0.5(\224\030\036\007\027\016\016 )0.5(\022\030\024\r\024\023\024\021\036\030\016 \r)]TJ /Span<>> BDC ( )Tj EMC [(\020\030\031\023\023\036 )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC (\031\035\034\021\030\026)Tj 0 Tw (-)Tj 0.09 Tw T* [(\r\031\022\024\r\t\n )0.5(\f\022\026\035\034\023\036\035\036\n )0.6(\002\t\035\026 )0.5(\f\021\026\021\017\f\021\017\004\036\f\022\017 )0.6(\027\017\032\036, )0.5(\004\036\n )]TJ 0.12 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \f)Tj /Span<>> BDC ( )Tj EMC (\220\035\036\022\021\030\024\022\024\026\020\031\035\016\006\017\036\005\ . \215\030\024\007\024\035\032\017\021\036\035\034\027\024\f\021\034 )Tj -0.001 Tw T* (\023\030\036\002\t\r\026\027\017\016 \r)Tj /Span<>> BDC ( )Tj EMC (\f\021\026\006\017\024\027\026\030\036 \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \f)Tj /Span<>> BDC ( )Tj EMC (\220\035\036\022\021\030\024\022\024\026\020\031\035\016)Tj 0 Tw (-)Tj 0.049 Tw T* (\006\017\036\005 \002\t\035\026 \002\024\035\036\036 \007\035\017\021\036\ \035\034\027\024\005, \004\021\024 \f\021\026\021\017\f\021\017\004\036\f\ \022\017 \027\026)Tj 0 Tw (-)Tj T* (\004\017\n\024 [7].)Tj 0.029 Tw T* (\200 \007\026\027\027\024\n \017\f\f\035\036\007\024\r\026\027\017\017 \f\ \007\036\035\026\027 \r\t\r\024\007 \024)Tj /Span<>> BDC ( )Tj EMC (\021\024\n, \004\021\024 \031\035\034)Tj 0 Tw (-)Tj 0.122 Tw T* (\021\030\026\r\031\022\024\r\024\005 \f\022\026\035\034\023\036\035\034\ \016\r\035\016\036\021\f\016 \002\036\f\006\036\027\027\t\n \017\027\f\021\ \030\031)Tj 0 Tw (-)Tj 0.13 Tw T* (\n\036\027\021\024\n \r)Tj /Span<>> BDC ( )Tj EMC (\022\024\035\024\030\036\022\021\026\035\034\027\024\005 \b\017\030\031\030\ \020\017\017. \224)Tj /Span<>> BDC ( )Tj EMC (\021\024\004\022\017 \030\036\027\017\016 )Tj 0.007 Tw T* [(\r\030\036\n\036\027\017 )0.5(\024\023\036\030\026\006\017\017, )0.6(\022\030\024\r\024\023\024\021\036\030\017 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 14.453 0 Td [(\007\035\017\021\036\035\034\027\024\f\021\017 )0.6(\023\030\036)]TJ 0 Tw (-)Tj 0.009 Tw -14.453 -1.218 Td (\002\t\r\026\027\017\016 \r)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\034\027\017\006\036 \031\035\034\021\030\026\r\031\022\024\ \r\024\005 \f\022\026\035\034\023\036\035\034 \023\024\022\026)Tj 0 Tw (-)Tj 0.129 Tw T* (\026\035 \f\036\002\016 \035\031\004\001\036, \004\036\n \002\017\023\024\ \035\016\030\027\026\016 \220\035\036\022\021\030\024\022\024\026\020\031\ \035\016\006\017\016 )Tj 0.291 Tw 23.244 35.316 Td (\r\024 \r\030\036\n\016 \024\023\036\030\026\006\017\005 \023\024)Tj /Span<>> BDC ( )Tj EMC (\031\007\026\035\036\027\017\033 \022\024\035\024\030\036\022\021\026\035\ \034\027\024\020\024 )Tj 0 Tw T* (\030\026\022\026.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 275.0305 676.1179 Tm [(\020)21(\026\027\r\241\224\034\022\031\034)]TJ 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0 Tc 0.316 Tw 10 0 0 10 274.9606 651.7618 Tm (\224\021\026\021\017\f\021\017\004\036\f\022\017 \027\026\004\017\n\t\b\ \030\026\035\017\004\017\005 \r)Tj /Span<>> BDC ( )Tj EMC (\007\r\031\b \020\030\031\023\023\026\b )Tj 0.134 Tw T* (\027\036\021. \211\035\034\021\030\026\r\031\022\024\r\024\005 \f\022\026\ \035\034\023\036\035\034, \022\026\022 \017)Tj /Span<>> BDC ( )Tj EMC (\220\035\036\022\021\030\024\022\024\026\020\031)Tj 0 Tw (-)Tj 0.081 Tw T* (\035\016\021\024\030, \016\r\035\016\033\021\f\016 \006\036\027\027\t\n\017\ \017\027\f\021\030\031\n\036\027\021\026\n\017 \r)Tj /Span<>> BDC ( )Tj EMC (\022\024\035\024\030\036\022)Tj 0 Tw (-)Tj 0.094 Tw 0 -1.218 TD (\021\026\035\034\027\024\005 \b\017\030\031\030\020\017\017 \007\035\016\ \030\026\f\f\036\004\036\027\017\016 \021\022\026\027\036\005 \017)Tj /Span<>> BDC ( )Tj EMC (\020\036\n\024\f\021\026)Tj 0 Tw (-)Tj 0.262 Tw 0 -1.218 TD [(\026 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 2.397 0 Td [(\027\036\026\n\036\027\017\n\t )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 6.585 0 Td [(\024\023\036\030\026\006\017\024\027\027\024\005. )0.6(\236\f\023\024\035\034\024\r\026\027\017\036 )]TJ 0.367 Tw -8.982 -1.218 Td (\220\021\017\b \031\f\021\030\024\005\f\021\r \f\007\036\035\026\035\024\ \n\026\035\024\017\027\r\026\017\r\027\t\036 \023\024\007\b\024\007\t \ )Tj 0.234 Tw 0 -1.218 TD (\220\235\235\036\022\021\017\r\027\t\n\017 \017)Tj /Span<>> BDC ( )Tj EMC (\002\036\024\023\026\f\027\t\n\017 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\f\035\024\032\027\t\b \022\024\035\024)Tj 0 Tw (-)Tj 0.175 Tw T* (\030\036\022\021\026\035\034\027\t\b \024\023\036\030\026\006\017\016\b.\ \212\024\035\020\024\f\030\024\004\027\024\036 \r\035\017\016\027\017\036\ \220\021\017\b )Tj 0.057 Tw T* (\031\f\021\030\024\005\f\021\r \027\026)Tj /Span<>> BDC ( )Tj EMC (\021\036\004\036\027\017\036 \026\002\024\035\036\r\026\027\017\016 \017\ )Tj /Span<>> BDC ( )Tj EMC (\036\020\024 \017\f\b\024\007\t \036\013\201 )Tj 0.133 Tw 0 -1.218 TD (\023\030\036\007\f\021\024\017\021 \024\023\030\036\007\036\035\017\021\034\ . \224\031\013\036\f\021\r\031\033\021 \027\024\r\t\036 \220\027\036\030\ \020\036\021\017)Tj 0 Tw (-)Tj -0.018 Tw 0 -1.218 TD (\004\036\f\022\017\036 \031\f\021\030\024\005\f\021\r\026, \f\024\004\036\ \021\026\033\013\017\036 \220\021\017 \023\030\036\017\n\031\013\036\f\021\ \r\026, \027\024 )Tj 0 Tw 0 -1.218 TD (\007\024\022\026\026\021\036\035\034\f\021\r\026 \017\b \023\030\036\r\024\ \f\b\024\007\f\021\r\026 \036\013\201 \027\036\021.)Tj /T1_2 1 Tf 0.023 Tw 0 -2.436 TD (INFORMATION ABOUT THE)Tj /Span<>> BDC ( )Tj EMC (AUTHORS \(ORCID\))Tj /T1_0 1 Tf 0.009 Tw 0 -1.218 TD [(Joanna Sander)-38(w)-12(ale)]TJ /Span<>> BDC ( )Tj EMC [(\227 K)-16(astur)-23.9(ba Medical college, MA)58.1(HE, )]TJ -0.079 Tw T* [(Manip)32(al, K)-16(ar)-15(na)15(t)15(ak)-16.9(a, India; ORCID)]TJ /Span<>> BDC ( )Tj EMC (0009-0004-5583-2442)Tj 0.271 Tw T* [(Annapp)32(a K)25.1(ud)-17(v)-15(a)]TJ /Span<>> BDC ( )Tj EMC [(\227 K)-16(astur)-23.9(ba Medical college, MA)58(HE, )]TJ -0.079 Tw T* [(Manip)32(al, K)-16(ar)-15(na)15(t)15(ak)-16.9(a, India; ORCID)]TJ /Span<>> BDC ( )Tj EMC (0009-0000-4946-6176)Tj 0.309 Tw T* [(Dr. )0.5(Ji)-23.9(t)-13(hin )0.5(A)-14(br)-33(aham )0.6(Ja)-17(cob)]TJ /Span<>> BDC ( )Tj EMC 11.719 0 Td [(\227 )0.5(w)-14(or)-24(k)-15.9(ing )0.5(as )0.5(Assist)15(ant )]TJ 0.311 Tw -11.719 -1.218 Td [(p)25(r)-32(ofessor )0.6(in )0.5(t)-13(he)]TJ /Span<>> BDC ( )Tj EMC 7.478 0 Td [(Dep)32(ar)-22(tment )0.6(of)]TJ /Span<>> BDC ( )Tj EMC 6.606 0 Td [(Gener)-33(al )0.6(Sur)-32(ger)-24(y )0.5(a)15(t )]TJ 0.353 Tw -14.084 -1.218 Td [(KMC, Manip)32(al. Af\251l)-31(ia)15.1(ted t)17(o)]TJ /Span<>> BDC ( )Tj EMC [(an inst)-32(i)-24(tute wi)-24(t)-12.9(h high )]TJ 0.702 Tw T* [(r)-24(egar)-23.9(d for r)-24(esear)-32(ch and publ)-31(ica)15(t)-32(ions, K)-16(astur)-24(ba )]TJ 0.48 Tw T* [(Medical college, MA)58(HE, Manip)32(al, K)-15.9(ar)-15(na)15(t)15(ak)-17(a, India; )]TJ 0 Tw T* (ORCID)Tj /Span<>> BDC ( )Tj EMC (0000-0002-7277-7295)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 42.5896 335.1339 Tm (REFERENCES)Tj 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0 Tc -0.002 Tw 8 0 0 8 42.5197 322.2992 Tm (1.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Ho)17(t)-30(t)15(a)]TJ /Span<>> BDC ( )Tj EMC 2.506 0 Td [(T, )0.5(T)40(ak)-16(ifuji)]TJ /Span<>> BDC ( )Tj EMC 4.124 0 Td [(K, )0.5(Y)40(okoy)22(ama)]TJ /Span<>> BDC ( )Tj EMC 5.122 0 Td [(S, )0.5(Ma)15(tsud)42(a)]TJ /Span<>> BDC ( )Tj EMC 4.404 0 Td [(K, )0.5(e)-11.9(t)]TJ /Span<>> BDC ( )Tj EMC 1.995 0 Td [(al. )0.6(L)-32(i)-24(ter)-33(a)15(tur)-23.9(e )0.5(r)-24(ev)-15.9(iew )]TJ -0.015 Tw -19.447 -1.25 Td (of)Tj /Span<>> BDC ( )Tj EMC [(t)-12.9(he ener)-32(g)16(y sour)-31.9(ces for per)-23.9(for)-16(ming l)-15.9(ap)32(ar)-32(oscopic col)30(or)-23.9(ec)-16(t)15(al sur)-31.9(ger)-24(y. )]TJ /T1_3 1 Tf 0.129 Tw 0 -1.25 TD [(W)29(orld J Gastrointest Surg.)]TJ /T1_0 1 Tf ( 2012 Jan 27;4\(1\):1\2268. PMID: 22347536; )Tj 0.023 Tw T* (PMCID: PMC3277876.)Tj 0.337 Tw T* (2.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Cam)10(p)32(a)-17(gna)-17(cc)-24(i)]TJ /Span<>> BDC ( )Tj EMC [(R, de Sanc)-15.9(t)-32(is)]TJ /Span<>> BDC ( )Tj EMC [(A, Bald)42(ar)-24(ell)-30.9(i)]TJ /Span<>> BDC ( )Tj EMC [(M, R)-24(imini)]TJ /Span<>> BDC ( )Tj EMC [(M, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC (al. )Tj 0.039 Tw -1.296 -1.25 Td [(Elec)-16(tr)-31.9(o)17(t)-13(her)-16(mal bipol)-16(ar vessel seal)-30.9(ing dev)-16(ice vs. ul)56(tr)-32.9(asonic coa)-16.9(gul)-16(a)15(t)]TJ 0 Tw (-)Tj 0.162 Tw T* [(ing shear)-9.9(s in l)-16(ap)32(ar)-32(oscopic colec)-16(t)17(omies: a)]TJ /Span<>> BDC ( )Tj EMC [(com)10(p)32(ar)-33(a)15(t)-32(i)-16(ve stud)17.1(y. )]TJ /T1_3 1 Tf 0 Tw (Surg )Tj T* (Endosc.)Tj /T1_0 1 Tf -0.03 Tw [( 2007 Sep;21\(9\):1526\22631. Epub 2007 F)10(eb 8. PMID: 17287913.)]TJ 0.207 Tw T* (3.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(T)40(ak)-17(ad)42(a)]TJ /Span<>> BDC ( )Tj EMC [(M, Ichihar)-33(a)]TJ /Span<>> BDC ( )Tj EMC [(T, K)25(ur)-32(od)42(a)]TJ /Span<>> BDC ( )Tj EMC [(Y. Com)10(p)32(ar)-33(a)15(t)-32(i)-16(ve stud)17(y of)]TJ /Span<>> BDC ( )Tj EMC [(elec)-15.9(tr)-32(o)]TJ 0 Tw (-)Tj 0.17 Tw -1.296 -1.25 Td [(t)-13(her)-16(mal bipol)-15.9(ar vessel sealer and ul)56(tr)-33(asonic coa)-17(gul)-15.9(a)15(t)-32(ing shear)-10(s in )]TJ 0.155 Tw T* [(l)-16(ap)32(ar)-32(oscopic colec)-15.9(t)17(omy. )]TJ /T1_3 1 Tf (Surg Endosc.)Tj /T1_0 1 Tf [( 2005 F)10(eb;19\(2\):226\2268. Epub )]TJ 0.023 Tw T* (2004 Dec 2. PMID: 15573241.)Tj -0.003 Tw T* (4.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(T)40(ar)-32(gar)-32(ona)]TJ /Span<>> BDC ( )Tj EMC [(EM, Bal)-15.9(a)-17(gue)]TJ /Span<>> BDC ( )Tj EMC [(C, Mar)-37(in)]TJ /Span<>> BDC ( )Tj EMC [(J, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Ener)-31.9(g)16(y sour)-31.9(ces for l)-16(ap)32(ar)-32(o)]TJ 0 Tw (-)Tj 0.065 Tw -1.296 -1.25 Td [(scopic colec)-15.9(t)17(omy: a)]TJ /Span<>> BDC ( )Tj EMC [(p)25(r)-32(ospec)-16(t)-32(i)-16(ve r)-33(and)-16(omized com)10(p)32(ar)-36.9(ison of)]TJ /Span<>> BDC ( )Tj EMC (conven)Tj 0 Tw (-)Tj 0.322 Tw T* [(t)-32(ional elec)-16(tr)-32(osur)-32(ger)-23.9(y, bipol)-16(ar com)10(puter-contr)-31.9(olled elec)-16(tr)-32(osur)-31.9(ger)-24(y )]TJ 0.233 Tw 29.055 17.5 Td [(and )0.6(ul)56(tr)-33(asonic )0.6(dissec)-16(t)-32(ion. )0.6(Oper)-33(a)15.1(t)-32(i)-16(ve )0.5(outcome )0.6(and )0.6(costs )0.6(anal)35(y)-13(sis. )]TJ /T1_3 1 Tf 0.023 Tw T* (Surg Innov.)Tj /T1_0 1 Tf ( 2005 Dec;12\(4\):339\22644.)Tj 0.01 Tc 0.363 Tw T* (5.)Tj /Span<>> BDC ( )Tj EMC 1.325 0 Td [(S)-15.7(ist)15.3(a)]TJ /Span<>> BDC ( )Tj EMC [(F, A)-13.7(br)-21.7(uz)-23.7(zese)]TJ /Span<>> BDC ( )Tj EMC [(V, S)-23.7(chie)-11.7(tr)-31.7(oma)]TJ /Span<>> BDC ( )Tj EMC [(M, e)-11.7(t)]TJ /Span<>> BDC ( )Tj EMC [(al. New Ul)56.3(tr)-32.7(asonic)10( )]TJ 0 Tc 0.307 Tw -1.325 -1.25 Td [(S)-24(calpel ver)-9.9(sus Convent)-32(ional Hemost)15(asis in R)-24(ight Col)30(on Sur)-32(ger)-24(y: )]TJ -0.015 Tw T* (A)Tj /Span<>> BDC ( )Tj EMC [(P)35(r)-32(ospec)-16(t)-31.9(i)-16(ve R)-10(and)-16(omized Contr)-31.9(olled Cl)-31(inical T)50(r)-37(ial. )]TJ /T1_3 1 Tf (Dig Surg.)Tj /T1_0 1 Tf [( 1 Mar)-32(ch )]TJ 0 Tw T* (2014;30\(4-6\):355\226361.)Tj 0.01 Tw T* (6.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(R)-24(imond)42(a)]TJ /Span<>> BDC ( )Tj EMC 3.733 0 Td [(R, )0.5(Ar)-23.9(ez)-24(zo)]TJ /Span<>> BDC ( )Tj EMC 3.919 0 Td [(A, )0.5(Gar)-23.9(r)-32(one, )0.5(e)-12(t)]TJ /Span<>> BDC ( )Tj EMC 5.654 0 Td [(al. )0.5(Elec)-15.9(tr)-32(o)17(t)-13(her)-15.9(mal )0.5(Bipol)-16(ar )0.6(V)30(essel )]TJ 0.002 Tc 0.35 Tw -14.603 -1.25 Td [(Seal)-31.4(ing Sy)-13.4(stem vs. Ul)55.6(tr)-33.4(asonicS)-24.5(calpel in Col)29.6(or)-24.4(ec)-16.4(t)14.5(al L)-32.4(ap)31.6(ar)-32.4(oscopic)2( )]TJ 0 Tc 0.126 Tw T* [(Sur)-32(ger)-23.9(y: A)]TJ /Span<>> BDC ( )Tj EMC [(P)35(r)-32(ospec)-16(t)-32(i)-16(ve, R)-10(and)-16(omized S)15(tud)17(y. )]TJ /T1_3 1 Tf (Diseases of)Tj /Span<>> BDC ( )Tj EMC (the Colon & )Tj 0 Tw T* [(R)21(ectum.)]TJ /T1_0 1 Tf 0.023 Tw [( 52\(4\):p 657\226661, Ap)25(r)-37(il 2009. |)]TJ 0.011 Tw T* (7.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(K)-16(al)-15.9(ar)-37(i)]TJ /Span<>> BDC ( )Tj EMC [(P, Nir)-24(hale)]TJ /Span<>> BDC ( )Tj EMC [(DS, V)25(ajja)]TJ /Span<>> BDC ( )Tj EMC [(R, Gal)-16(am)]TJ /Span<>> BDC ( )Tj EMC [(P. Com)10(p)32(ar)-37(ison of)]TJ /Span<>> BDC ( )Tj EMC [(Convent)-32(ional )]TJ -0.015 Tw -1.296 -1.25 Td [(Bipol)-16(ar Elec)-16(tr)-31.9(o)-16(cauter)-24(y and Ul)56(tr)-32.9(asonic Ul)56.1(tr)-33(asonic S)-24(calpel in Col)30(or)-23.9(ec)-16(t)15(al )]TJ 0.013 Tc 0.489 Tw T* [(Cancer Sur)-32.2(ger)-37.3(ies. )]TJ /T1_3 1 Tf -0.013 Tw (Cureus)Tj /T1_0 1 Tf 0.49 Tw [(. )0.6(2022 )0.6(Mar )0.6(17;14\(3\):e23255. )0.5(PMID:)13.1( )]TJ 0 Tc 0.023 Tw T* (35449609; PMCID: PMC9012577)Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 0 Tw 7.5 0 0 7.5 42.5197 42.7216 Tm [(\034\201\025\b\222\016\017)-9.9(\026\021\r\215\025\016 \025\211\215\025\212\016\215\026\201\025\r\025\016\ \215\001\235\t\205\211\001\026)11(\016\t\214\215\025\016 \021\b\b)-10(\t\016\211\025\r\001\215\021\016 )]TJ 0 -1 TD [(\242\215\016\201\202)10(\016\026\021\f\016\b\017\021 \200\b)-10(\026\201\025\207\b)-10(\026\r \r\022\017)10(\025\t\025\201\016\017)-10(\026)11(\001\t\214\215\025\207 \021\201\200\201\202\021\021)]TJ 41.119 1 Td [(A Pr)20(ospectiv)12(e Single Centr)31(e Obser)-20.9(v)10(ational Study )]TJ 3.383 -1 Td [(on\022Ener)31.1(gy\022De)11(vices in Color)31(ectal Sur)31(ger)-31(y)]TJ -44.502 96.622 Td [(\036\033\030\031\030\217\n)-20.9(\035\210\217\241\003 \013\032)50(\n)42(\032\210\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj /T1_5 1 Tf 25 0 0 25 504.6646 56.0378 Tm (119)Tj ET endstream endobj 1602 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.034 Tw 10 0 0 10 70.8661 724.8299 Tm (\023\024)Tj /Span<>> BDC ( )Tj EMC (\007\030\036\027\026\032\031. \025\030\024\r\024\023\024\021\036\030\016\ \027\036 \031\004\017\021\t\r\026\035\026\f\034 \r)Tj /Span<>> BDC ( )Tj EMC (\017\f\f\035\036\007\024)Tj 0 Tw (-)Tj 0 -1.218 TD (\r\026\027\017\017 \224\017\f\021\t \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021.)Tj -0.013 Tw T* (\236\f\f\035\036\007\024\r\026\027\017\036, \023\030\024\r\036\007\201\027\ \027\024\036 \224\017\f\021\024\005 \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. \r)Tj /Span<>> BDC ( )Tj EMC (\236\021\026\035\017\017 )Tj 0.149 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (2013 \020\024\007\031, \f)Tj /Span<>> BDC ( )Tj EMC (\r\t\002\024\030\022\024\005 211 \004\036\035\024\r\036\022 \023\030\036\ \007\f\021\026\r\035\016\035\024 )Tj 0.364 Tw T* (\f\024\002\024\005 \023\030\024\f\023\036\022\021\017\r\027\024\036 \030\ \026\027\007\024\n\017\017\030\024\r\026\027\027\024\036 \022\024\027\021\ \030\024)Tj 0 Tw (-)Tj 0.081 Tw T* (\035\017\030\031\036\n\024\036 \007\r\024\005\027\024\036 \f\035\036\023\ \024\036 \017\f\f\035\036\007\024\r\026\027\017\036. \200)Tj /Span<>> BDC ( )Tj EMC (\017\f\f\035\036\007\024)Tj 0 Tw (-)Tj 0.163 Tw 0 -1.218 TD (\r\026\027\017\036 \002\t\035\017 \r\022\035\033\004\036\027\t \023\026\006\ \017\036\027\021\t, \023\036\030\036\027\036\f\001\017\036 \020\036\n\017\ )Tj 0 Tw (-)Tj 0.138 Tw 0 -1.218 TD (\022\024\035\220\022\021\024\n\017\033)Tj /Span<>> BDC ( )Tj EMC (\227 \024\021\022\030\t\021\031\033 \024\023\036\030\026\006\017\033 \023\ \024)Tj /Span<>> BDC ( )Tj EMC (\023\024\r\024\007\031 \030\026\022\026 )Tj 0.414 Tw T* (\023\030\026\r\024\005 \023\024\035\024\r\017\027\t \024\002\024\007\024\ \004\027\024\005 \022\017\001\022\017 \(\030\026\022 \f\035\036\023\024\005\ )Tj 0.2 Tw T* (\022\017\001\022\017, \r\024\f\b\024\007\016\013\036\005 \024\002\024\007\ \024\004\027\024\005 \022\017\001\022\017, \023\036\004\201\027\024\004\027\ \024\020\024 )Tj 0.205 Tw T* [(\017\020\017\002\026 )0.5(\017\035\017 \023\024\023\036\030\036\004\027\024\005 )0.5(\024\002\024\007\024\004\027\024\005 )0.5(\022\017\001\022\017\). \200)]TJ /Span<>> BDC ( )Tj EMC 20.215 0 Td (\220\021\024\n )Tj 0.085 Tw -20.215 -1.218 Td [(\017\f\f\035\036\007\024\r\026\027\017\017 )0.6(\f\030\026\r\027\017\r\026\035\017\f\034 )0.5(\030\036\031\035\034\021\026\021\t )0.6(\023\030\017\n\036\027\036\027\017\016 )]TJ 0.286 Tw 0 -1.218 TD (\027\024\r\024\020\024 \031\035\034\021\030\026\r\031\022\024\r\024\020\ \024 \f\022\026\035\034\023\036\035\016 \(NUS\) \017)Tj /Span<>> BDC ( )Tj EMC (\021\030\026\007\017)Tj 0 Tw (-)Tj 0.105 Tw 0 -1.218 TD (\006\017\024\027\027\024\020\024 \020\036\n\024\f\021\026\026 \(\230\206\ \) [5]. NUS \024\021\027\024\f\017\021\f\016 \022)Tj /Span<>> BDC ( )Tj EMC (\027\024\r\024)Tj 0 Tw (-)Tj 0.17 Tw 0 -1.218 TD [(\n\031 \031\035\034\021\030\026\r\031\022\024\r\024\n\031 \027\026\022\024\ \027\036\004\027\017\022\031 \(NUS; FOCUS L)35(ong )]TJ 0.083 Tw T* [(Cur)-32(vedS)-15.9(hear)-10(s, Et)-13(hiconEnd)-15.9(o-Sur)-32(ger)-23.9(y Inc., \037\017\027\006\017\027\027\026\021\017, )]TJ -0.008 Tw T* [(\210\020\026\005\024, )0.5(\224\221\202\) \f)]TJ /Span<>> BDC ( )Tj EMC 5.91 0 Td [(\027\026\022\024\027\036\004\027\017\022\024\n )0.5(\n\036\027\036\036 )0.5(5 )0.5(\n\n, \022\024\021\024\030\t\005 )0.5(\007\024)]TJ 0 Tw (-)Tj -5.91 -1.218 Td (\f\021\031\023\036\027 \f)Tj /Span<>> BDC ( )Tj EMC (2009 \020\024\007\026 [5].)Tj 0.185 Tw T* (\225\021\017 \023\026\006\017\036\027\021\t \002\t\035\017 \030\026\027\007\ \024\n\017\017\030\024\r\026\027\t \027\026)Tj /Span<>> BDC ( )Tj EMC (\007\r\036 \020\030\031\023)Tj 0 Tw (-)Tj 0.147 Tw T* (\023\t \r)Tj /Span<>> BDC ( )Tj EMC (\026\r\017\f\017\n\024\f\021\017 \024\021 \017\f\023\024\035\034\031\036\ \n\024\020\024 \220\027\036\030\020\036\021\017\004\036\f\022\024)Tj 0 Tw (-)Tj 0.092 Tw T* (\020\024 \031\f\021\030\024\005\f\021\r\026. \206\030\031\023\023\026 NU\ S \r\022\035\033\004\026\035\026 108 \023\026\006\017\036\027\021\024\r,\ )Tj 0.09 Tw T* (\026)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\026 \230\206)Tj /Span<>> BDC ( )Tj EMC (\227 103 \023\026\006\017\036\027\021\026. \206\030\031\023\023\026 \017\ )Tj /Span<>> BDC ( )Tj EMC (\004\036\021\t\030\036\b \b\017)Tj 0 Tw (-)Tj 0.039 Tw T* (\030\031\030\020\024\r-\022\024\027\f\031\035\034\021\026\027\021\024\r,\ \023\030\024\001\036\007\001\017\b \023\024\007\020\024\021\024\r\022\031\ \023\024)Tj /Span<>> BDC ( )Tj EMC (\030\036)Tj 0 Tw (-)Tj -0.098 Tw T* (\036\022\006\017\017 \022\024\035\024\030\036\022\021\026\035\034\027\024\ \020\024 \030\026\022\026, \023\030\024\r\024\007\017\035\026 \r\f\036 \b\ \017\030\031\030\020\017)Tj 0 Tw (-)Tj 0.028 Tw T* (\004\036\f\022\017\036 \024\023\036\030\026\006\017\017 \r)Tj /Span<>> BDC ( )Tj EMC (\031\f\035\024\r\017\016\b \024\021\022\030\t\021\024\005 \b\017\030\031\ \030\020\017\017. \212\r\036 )Tj 0.017 Tw T* (\b\017\030\031\030\020\017\004\036\f\022\017\036 \020\030\031\023\023\t \ \f\030\026\r\027\017\r\026\035\017 \023\024)Tj /Span<>> BDC ( )Tj EMC (\r\024\030\026\f\021\031 \023\026\006\017)Tj 0 Tw (-)Tj 0.006 Tw T* (\036\027\021\024\r \(\f\030\036\007\027\017\005 \r\024\030\026\f\021 64\ \020\024\007\026\) \017)Tj /Span<>> BDC ( )Tj EMC (\023\024\035\031 \(113)Tj /Span<>> BDC ( )Tj EMC (\n\031\032\004\017\027, )Tj -0.022 Tw T* (98 \032\036\027\013\017\027\), \030\026\n\036\030\031 \024\023\031\b\024\ \035\017, \036\036 \035\024\022\026\035\017\026\006\017\017, \020\017\f\ \021\024)Tj 0 Tw (-)Tj 0.153 Tw T* (\021\017\023\031 \017)Tj /Span<>> BDC ( )Tj EMC (\n\036\f\021\027\024\005 \017\027\r\026\017\r\027\024\f\021\017, \024\006\ \036\027\017\r\026\036\n\024\005 \023\024)Tj /Span<>> BDC ( )Tj EMC (\f\021\026)Tj 0 Tw (-)Tj 0.062 Tw T* (\007\017\017 \202\n\036\030\017\022\026\027\f\022\024\020\024 \024\002\255\ \036\007\017\027\036\027\027\024\020\024 \024\027\022\024\035\024\020\017\ \004\036\f\022\024\020\024 )Tj 0 Tw T* (\022\024\n\017\021\036\021\026 [5].)Tj 0.302 Tw T* [(\236\031\004\026\036\n\t\036 \023\026\030\026\n\036\021\030\t )0.5(\r\022\035\033\004\026\035\017: \r\030\036\n\016 \024\023\036\030\026\006\ \017\017, )]TJ 0.061 Tw T* (\024\002\255\036\n \024\021\007\036\035\016\036\n\024\020\024 \023\024)Tj /Span<>> BDC ( )Tj EMC (\007\030\036\027\026\032\031 \(\023\036\030\r\t\036 1\2263)Tj /Span<>> BDC ( )Tj EMC (\007\027\016 \023\024)Tj 0 Tw (-)Tj 0.073 Tw T* (\f\035\036 \024\023\036\030\026\006\017\017\), \022\024\005\022\024-\007\ \036\027\034 \017)Tj /Span<>> BDC ( )Tj EMC (\024\f\035\024\032\027\036\027\017\016 \r)Tj /Span<>> BDC ( )Tj EMC (\022\026\004\036\f\021\r\036 )Tj 0.009 Tw T* (\024\f\027\024\r\027\t\b \030\036\031\035\034\021\026\021\024\r; \224\t\ \r\024\030\024\021\024\004\027\t\005 \026\035\034\002\031\n\017\027 \027\ \026)Tj /Span<>> BDC ( )Tj EMC (1, )Tj 0.029 Tw T* [(2, )0.5(3, )0.5(6-\005 )0.6(\023\024\f\035\036\024\023\036\030\026\006\017\024\027\027\t\036 )0.6(\007\027\017 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 14.795 0 Td [(\224-\030\036\026\022\021\017\r\027\t\005 )0.6(\002\036)]TJ 0 Tw (-)Tj -0.004 Tw -14.795 -1.218 Td [(\035\024\022 )0.6(\(\224\217\207\) )0.6(\027\026)]TJ /Span<>> BDC ( )Tj EMC 5.368 0 Td [(1, )0.6(2, )0.5(3, )0.6(6-\005 )0.6(\023\024\f\035\036\024\023\036\030\026\006\017\024\027\027\t\036 )0.6(\007\027\017 )0.6(\r)]TJ /Span<>> BDC ( )Tj EMC 15.466 0 Td (\022\026)Tj 0 Tw (-)Tj 0.093 Tw -20.834 -1.218 Td (\004\036\f\021\r\036 \r\021\024\030\017\004\027\t\b \023\024\022\026\026\ \021\036\035\036\005. \025\024\027\006\036\027\021\030\026\006\017\016 \f\ \t\r\024)Tj 0 Tw (-)Tj -0.05 Tw T* (\030\024\021\024\004\027\024\020\024 \026\035\034\002\031\n\017\027\026 \ \023\024\f\035\036 \024\023\036\030\026\006\017\017 \017\n\036\030\016\035\ \026\f\034 \007\035\016 )Tj 0.178 Tw T* [(\r\t\016\r\035\036\027\017\016 \017\f\021\024\013\036\027\017\016 )0.5(\002\036\035\022\026 \r\f\035\036\007\f\021\r\017\036 \035\017\n\235\024\ \030\036\017. )]TJ 0.095 Tw T* (\025\024\027\006\036\027\021\030\026\006\017\016 \224\217\207 \017\f\023\ \024\035\034\024\r\026\035\026\f\034 \r)Tj /Span<>> BDC ( )Tj EMC (\022\026\004\036\f\021\r\036 \017\027\007\017)Tj 0 Tw (-)Tj 0.064 Tw T* (\022\026\021\024\030\026 \r\024\f\023\026\035\036\027\017\016, \022\024\021\ \024\030\024\036 \004\026\f\021\024 \f\035\031\032\017\021 \022\024\f\r\036\ \027\027\024\005 )Tj 0 Tw T* (\023\030\017\004\017\027\024\005 \020\017\023\024\026\035\034\002\031\n\017\ \027\036\n\017\017 [5].)Tj 0.432 Tw T* (\207\t\035\024 \024\021\n\036\004\036\027\024, \004\021\024 \017\f\023\024\ \035\034\024\r\026\027\017\036 \203\211\224 \023\030\017\r\036\035\024 \ )Tj 0.082 Tw T* (\022)Tj /Span<>> BDC ( )Tj EMC (\f\024\022\030\026\013\036\027\017\033 \r\030\036\n\036\027\017 \024\023\ \036\030\026\006\017\017, \024\002\255\036\n\026 \023\024\f\035\036\024\023\ \036)Tj 0 Tw (-)Tj 0.323 Tw T* (\030\026\006\017\024\027\027\024\020\024 \007\030\036\027\026\032\026 \017\ )Tj /Span<>> BDC ( )Tj EMC (\024\002\013\036\005 \023\030\024\007\024\035\032\017\021\036\035\034\027\ \024\f\021\017 )Tj 0.053 Tw T* (\023\030\036\002\t\r\026\027\017\016 \r)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\034\027\017\006\036. \200\f\036 \220\021\017 \030\026\035\017\ \004\017\016 \002\t\035\017 \f\021\026)Tj 0 Tw (-)Tj -0.015 Tw T* (\021\017\f\021\017\004\036\f\022\017 \027\026\004\017\n\t\n\017 \n\036\032\ \007\031 \007\r\031\n\016 \020\030\031\023\023\026\n\017. \230\026\022\032\ \036 )Tj 0.126 Tw T* (\002\t\035\024 \024\021\n\036\004\036\027\024 \027\026\004\017\021\036\035\ \034\027\024\036 \f\027\017\032\036\027\017\036 \031\030\024\r\027\016 \026\ \035\034)Tj 0 Tw (-)Tj 0.036 Tw T* (\002\031\n\017\027\026 \027\026)Tj /Span<>> BDC ( )Tj EMC (1, 2, 3-\005 \023\024\f\035\036\024\023\036\030\026\006\017\024\027\027\t\ \036 \007\027\017 \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 )Tj 0 Tw T* (\206\025 \023\024)Tj /Span<>> BDC ( )Tj EMC (\f\030\026\r\027\036\027\017\033 \f)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\024\005 \203\211\224 [5].)Tj 0.153 Tw T* (\215\024\007\r\024\007\016 \017\021\024\020, \n\024\032\027\024 \f\022\026\ \026\021\034, \004\021\024 \203\211\224 \016\r\035\016\036\021\f\016 \023\ \024)Tj 0 Tw (-)Tj 0.034 Tw T* (\035\036\027\t\n \017\027\f\021\030\031\n\036\027\021\024\n \r)Tj /Span<>> BDC ( )Tj EMC (\b\017\030\031\030\020\017\017 \021\024\035\f\021\024\005 \022\017\001\022\ \017, \023\024)Tj 0 Tw (-)Tj 0.046 Tw T* [(\f\022\024\035\034\022\031 )0.5(\024\027 \031\023\030\024\013\026\036\021 )0.5(\024\023\036\030\026\006\017\033, )0.5(\f\024\022\030\026\013\026\036\021 \036\201 )0.5(\r\030\036\n\016, )]TJ 0.07 Tw 23.244 64.543 Td (\022\030\024\r\024\023\024\021\036\030\033, \035\017\n\235\024\030\036\033\ , \026)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\032\036 \024\002\036\f\023\036\004\017\r\026\036\021 \023\024\ \007)Tj 0 Tw (-)Tj 0.273 Tw T* (\007\036\030\032\026\027\017\036 \026\007\036\022\r\026\021\027\024\020\024\ \026\023\026\f\026 \002\036\035\022\026. \200)Tj /Span<>> BDC ( )Tj EMC (\030\036\031\035\034\021\026\021\036 )Tj 0.027 Tw T* (\023\026\006\017\036\027\021\t \r\024\f\f\021\026\027\026\r\035\017\r\026\ \033\021\f\016 \002\t\f\021\030\036\036, \026)Tj /Span<>> BDC ( )Tj EMC (\024\f\035\024\032\027\036\027\017\016 )Tj 0 Tw T* (\r\024\027\017\022\026\033\021 \030\036\032\036 [5].)Tj 0.194 Tw T* [(\212\030\031\020\024\036 \026\027\026\035\024\020\017\004\027\024\036 )0.5(\017\f\f\035\036\007\024\r\026\027\017\036 \002\t\035\024 \023\030\024\r\ \036\007\036\027\024 )]TJ 0.149 Tw T* (\217\017\n\024\027\007\024\005 \017)Tj /Span<>> BDC ( )Tj EMC [(\f\024\026\r\021. )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC (\236\021\026\035\017\017 \r)Tj /Span<>> BDC ( )Tj EMC [(2009 \020\024\007\031. \225\021\024 )0.5(\002\t\035\024 )]TJ 0.097 Tw 0 -1.218 TD (\023\030\024\f\023\036\022\021\017\r\027\024\036 \030\026\027\007\024\n\017\ \017\030\024\r\026\027\027\024\036 \022\024\027\021\030\024\035\017\030\ \031\036\n\024\036 )Tj 0.171 Tw 0 -1.218 TD (\007\r\024\005\027\024\036 \f\035\036\023\024\036 \017\f\f\035\036\007\024\ \r\026\027\017\036 \f)Tj /Span<>> BDC ( )Tj EMC (\030\026\n\036\030\024\n \r\t\002\024\030\022\017 )Tj 0.101 Tw T* (140 \023\026\006\017\036\027\021\024\r \(\023\024 70 \r)Tj /Span<>> BDC ( )Tj EMC (\022\026\032\007\024\005 \020\030\031\023\023\036\). \200)Tj /Span<>> BDC ( )Tj EMC (\017\f\f\035\036\007\024)Tj 0 Tw (-)Tj 0.168 Tw T* (\r\026\027\017\036 \002\t\035\017 \r\022\035\033\004\036\027\t \023\026\006\ \017\036\027\021\t, \023\036\030\036\027\036\f\001\017\036 \035\026\023\026\ )Tj 0 Tw (-)Tj 0.05 Tw T* (\030\024\f\022\024\023\017\004\036\f\022\031\033 \215\206, \214\206 \017\ )Tj /Span<>> BDC ( )Tj EMC (\215\217. \224\030\026\r\027\017\r\026\035\024\f\034 \017\f\023\024\035\034\ \024)Tj 0 Tw (-)Tj 0.048 Tw T* (\r\026\027\017\036 \031\035\034\021\030\026\r\031\022\024\r\024\020\024\ \f\022\026\035\034\023\036\035\016 \017)Tj /Span<>> BDC ( )Tj EMC (\030\026\007\017\024\004\026\f\021\024\021\027\024\020\024 )Tj 0.107 Tw 0 -1.218 TD (\f\022\026\035\034\023\036\035\016 \007\035\016 \035\017\020\017\030\024\ \r\026\027\017\016 \f\024\f\031\007\024\r. \215\036\030\r\017\004\027\024\ \005 \022\024)Tj 0 Tw (-)Tj 0.078 Tw 0 -1.218 TD (\027\036\004\027\024\005 \021\024\004\022\024\005 \017\f\f\035\036\007\024\ \r\026\027\017\016 \002\t\035\024 \017\027\021\030\026\024\023\036\030\026\ \006\017\024\027)Tj 0 Tw (-)Tj 0.064 Tw 0 -1.218 TD (\027\024\036 \f\027\017\032\036\027\017\036 \022\030\024\r\024\023\024\021\ \036\030\017. \200\021\024\030\017\004\027\t\n\017 \022\024\027\036\004\027\ \t\n\017 )Tj -0.024 Tw T* (\021\024\004\022\026\n\017 \002\t\035\017 \017\027\021\030\026- \017)Tj /Span<>> BDC ( )Tj EMC (\023\024\f\035\036\024\023\036\030\026\006\017\024\027\027\t\036 \024\f\035\ \024\032\027\036)Tj 0 Tw (-)Tj T* (\027\017\016 \017)Tj /Span<>> BDC ( )Tj EMC (\r\030\036\n\016 \024\023\036\030\026\006\017\017 [6].)Tj 0.473 Tw T* [(\200\t\023\024\035\027\016\036\n\t\036 )0.6(\024\023\036\030\026\006\017\017 )0.5(\002\t\035\017 )0.6(\f\021\026\027\007\026\030\021\017\017\030\024\r\026\027\t )]TJ 0.087 Tw T* (\007\024)Tj /Span<>> BDC ( )Tj EMC [(\023\030\024\021\024\022\024\035\026. )0.5(\210\023\036\030\026\006\017\017 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC [(\030\026\n\022\026\b )0.5(\017\f\f\035\036\007\024\r\026\027\017\016 )0.5(\r\t)]TJ 0 Tw (-)Tj 0.212 Tw T* (\023\024\035\027\016\035\017 \007\r\026 \024\023\t\021\027\t\b \b\017\030\ \031\030\020\026, \022\026\032\007\t\005 \017)Tj /Span<>> BDC ( )Tj EMC (\022\024\021\024\030\t\b )Tj 0.233 Tw T* (\017\n\036\035 \024\023\t\021 \002\024\035\036\036 400 \035\026\023\026\030\ \024\f\022\024\023\017\004\036\f\022\017\b \022\024\035\024\030\036\022)Tj 0 Tw (-)Tj T* (\021\026\035\034\027\t\b \024\023\036\030\026\006\017\005 [6].)Tj -0.02 Tw T* (\210\002\013\026\016 \017\027\021\030\026\024\023\036\030\026\006\017\024\ \027\027\026\016 \022\030\024\r\024\023\024\021\036\030\016 \017)Tj /Span<>> BDC ( )Tj EMC (\r\030\036\n\016 \024\023\036)Tj 0 Tw (-)Tj 0.264 Tw T* (\030\026\006\017\017 \002\t\035\017 \f\024\023\024\f\021\026\r\017\n\t \r\ )Tj /Span<>> BDC ( )Tj EMC (\024\002\036\017\b \020\030\031\023\023\026\b. \210\002\013\026\016 )Tj 0.414 Tw T* (\004\026\f\021\024\021\026 \023\024\f\035\036\024\023\036\030\026\006\017\ \024\027\027\t\b \024\f\035\024\032\027\036\027\017\005 \f\024\f\021\026\ \r\017)Tj 0 Tw (-)Tj 0.251 Tw T* [(\035\026 )0.5(10,7%, )0.5(\004\021\024 )0.6(\002\t\035\024 )0.5(\f\024\023\024\f\021\026\r\017\n\024 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 15.67 0 Td [(\024\002\036\017\b )0.6(\020\030\031\023\023\026\b. )]TJ 0.263 Tw -15.67 -1.218 Td (\200)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\n \017\f\f\035\036\007\024\r\026\027\017\017 \f\007\036\035\ \026\027 \r\t\r\024\007 \024\002 \024\021\f\031\021\f\021\r\017\017 )Tj 0.036 Tw T* (\f\031\013\036\f\021\r\036\027\027\t\b \023\030\036\017\n\031\013\036\f\021\ \r \017\f\023\024\035\034\024\r\026\027\017\016 \030\026\007\017\024\004\ \026)Tj 0 Tw (-)Tj 0.102 Tw T* [(\f\021\024\021\027\024\020\024 )0.6(\f\022\026\035\034\023\036\035\016 )0.5(\023\024)]TJ /Span<>> BDC ( )Tj EMC 9.773 0 Td [(\f\030\026\r\027\036\027\017\033 )0.6(\f)]TJ /Span<>> BDC ( )Tj EMC 5.664 0 Td (\031\035\034\021\030\026\r\031\022\024\r\t\n )Tj 0.451 Tw -15.437 -1.218 Td (\f\022\026\035\034\023\036\035\036\n \r)Tj /Span<>> BDC ( )Tj EMC (\035\026\023\026\030\024\f\022\024\023\017\004\036\f\022\024\005 \022\024\ \035\024\030\036\022\021\026\035\034\027\024\005 )Tj 0 Tw T* (\b\017\030\031\030\020\017\017 [6].)Tj 0.008 Tc 0.404 Tw T* (\210\002\013\026\016 \017\027\021\030\026\024\023\036\030\026\006\017\024\ \027\027\026\016 \022\030\024\r\024\023\024\021\036\030\016 \017)Tj /Span<>> BDC ( )Tj EMC [(\r\030\036\n\016)8( )]TJ 0.08 Tw T* (\024\023\036\030\026\006\017\017 \002\t\035\017 \f\b\024\032\017\n\017 \r\ )Tj /Span<>> BDC ( )Tj EMC (\007\r\031\b \020\030\031\023\023\026\b. \210\002\013\026\016 \004\026)Tj 0 Tc 0 Tw (-)Tj 0.008 Tc 0.415 Tw T* [(\f\021\024\021\026 \023\024\f\035\036\024\023\036\030\026\006\017\024\027\ \027\t\b \024\f\035\024\032\027\036\027\017\005 \f\024\f\021\026\r\017\035\ \026)8( )]TJ 0.198 Tw T* (10,7%, \004\021\024 \002\t\035\024 \f\b\024\032\017\n \r)Tj /Span<>> BDC ( )Tj EMC (\024\002\036\017\b \020\030\031\023\023\026\b. \225\021\024 \017\f)Tj 0 Tc 0 Tw (-)Tj 0.008 Tc 0.243 Tw T* (\f\035\036\007\024\r\026\027\017\036 \023\030\017\001\035\024 \022)Tj /Span<>> BDC ( )Tj EMC (\r\t\r\024\007\031, \004\021\024 \027\036 \002\t\035\024 \f\031\013\036)Tj 0 Tc 0 Tw (-)Tj 0.008 Tc 0.336 Tw T* (\f\021\r\036\027\027\024\020\024 \023\030\036\017\n\031\013\036\f\021\r\026\ \017\f\023\024\035\034\024\r\026\027\017\016 \030\026\007\017\024\004\026\ )Tj 0 Tc 0 Tw (-)Tj 0.008 Tc 0.026 Tw T* (\f\021\024\021\027\024\020\024 \f\022\026\035\034\023\036\035\016 \023\024\ )Tj /Span<>> BDC ( )Tj EMC (\f\030\026\r\027\036\027\017\033 \f)Tj /Span<>> BDC ( )Tj EMC [(\031\035\034\021\030\026\r\031\022\024\r\t\n)7.9( )]TJ 0.334 Tw T* (\f\022\026\035\034\023\036\035\036\n \r)Tj /Span<>> BDC ( )Tj EMC [(\035\026\023\026\030\024\f\022\024\023\017\004\036\f\022\024\005 \022\024\ \035\024\030\036\022\021\026\035\034\027\024\005)8( )]TJ 0 Tw T* (\b\017\030\031\030\020\017\017)Tj /Span<>> BDC ( )Tj EMC ([6].)Tj 0.018 Tc 0.32 Tw T* (\215\024\f\022\024\035\034\022\031 \007\r\026 \031\f\021\030\024\005\f\021\ \r\026 \017\n\036\033\021 \030\026\027\t\036 \b\026\030\026\022)Tj 0 Tc 0 Tw (-)Tj 0.018 Tc 0.189 Tw T* (\021\036\030\017\f\021\017\022\017, \017\b \f\b\024\007\f\021\r\024 \027\ \036 \r\035\017\016\036\021 \027\026)Tj /Span<>> BDC ( )Tj EMC (\220\022\r\017\r\026\035\036\027\021)Tj 0 Tc 0 Tw (-)Tj 0.018 Tc 0.414 Tw T* (\027\024\f\021\034 \030\036\031\035\034\021\026\021\024\r. \216\024\021\ \016 \030\026\007\017\024\004\026\f\021\024\021\027\t\005 \f\022\026\035\ \034)Tj 0 Tc 0 Tw (-)Tj 0.018 Tc 0.751 Tw T* [(\023\036\035\034 \024\002\035\026\007\026\036\021 \023\030\036\r\024\f\b\ \024\007\027\024\005 \020\036\n\024\f\021\026\021\017\004\036\f\022\024\005\ )18( )]TJ 0.514 Tw T* (\f\023\024\f\024\002\027\024\f\021\034\033, \031\035\034\021\030\026\r\031\ \022\024\r\024\005 \f\022\026\035\034\023\036\035\034 \023\024\n\024)Tj 0 Tc 0 Tw (-)Tj 0.018 Tc 0.208 Tw T* [(\020\026\036\021 )0.5(\027\026)]TJ /Span<>> BDC ( )Tj EMC 3.679 0 Td [(\220\021\026\023\036 )0.5(\007\017\f\f\036\022\006\017\017. )0.5(\200\t\002\024\030 )0.5(\220\027\036\030\020\036\021\017\004\036\f\022\024\020\024)18( )]TJ 0.19 Tw -3.679 -1.218 Td (\031\f\021\030\024\005\f\021\r\026 \007\024\035\032\036\027 \f\024\024\021\ \r\036\021\f\021\r\024\r\026\021\034 \017\027\007\017\r\017\007\031\026\035\ \034)Tj 0 Tc 0 Tw (-)Tj 0.018 Tc T* (\027\t\n \023\030\036\007\023\024\004\021\036\027\017\016\n)Tj /Span<>> BDC ( )Tj EMC ([6].)Tj 0 Tc 0.192 Tw T* (\203\036\007\026\r\027\024 \025\026\035\026\030\017 \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. \023\030\024\r\036\035\017 \026\027\026\035\024\020\017\ \004\027\024\036 \017\f)Tj 0 Tw (-)Tj 0.349 Tw T* (\f\035\036\007\024\r\026\027\017\036 \r)Tj /Span<>> BDC ( )Tj EMC (\024\007\027\024\005 \017)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\034\027\017\006 \021\030\036\021\034\036\020\024 \031\030\024\ \r\027\016 )Tj 0.224 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\236\027\007\017\017. \037\036\035\034\033 \220\021\024\020\024 \017\f\f\ \035\036\007\024\r\026\027\017\016 \002\t\035\024 \f\030\026\r\027\036)Tj 0 Tw (-)Tj 0.239 Tw T* (\027\017\036 \017\f\023\024\035\034\024\r\026\027\017\016 \002\017\023\024\ \035\016\030\027\024\005 \220\035\036\022\021\030\024\022\024\026\020\031\ \035\016\006\017\017 )Tj 0.038 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\031\035\034\021\030\026\r\031\022\024\r\t\b \f\022\026\035\034\023\036\ \035\036\005 \r)Tj /Span<>> BDC ( )Tj EMC (\022\024\035\024\030\036\022\021\026\035\034\027\t\b \024\023\036)Tj 0 Tw (-)Tj -0.058 Tw T* [(\030\026\006\017\016\b. )0.5(\200)]TJ /Span<>> BDC ( )Tj EMC [(\220\021\024 \017\f\f\035\036\007\024\r\026\027\017\036 )0.5(\002\t\035\017 \r\022\035\033\004\036\027\t )0.5(\023\026\006\017\036\027\021\t )]TJ 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0 Tw 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\033\030\031\030\217\n)-20.9(\035\210\217\241\003 \013\032)50(\n)42(\032\210\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj -51.938 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 2)69(4, \023\0224, 202)23(5)]TJ 43.013 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 2)69(4, \023\0224, 202)23(5)]TJ /T1_2 1 Tf 25 0 0 25 19.9527 56.0378 Tm (118)Tj ET endstream endobj 1599 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.89 Tw 10 0 0 10 42.5197 517.8039 Tm (\236\f\f\035\036\007\024\r\026\027\017\016, \023\030\024\r\036\007\036\027\ \027\t\036 \025\026\035\026\030\017 \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. )Tj 0.053 Tw 0 -1.218 TD (\017)Tj /Span<>> BDC ( )Tj EMC (\217\017\n\024\027\007\024\005 \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021., \r\022\035\033\004\026\035\017 \021\024\021 \032\036 \ \f\023\036\022\021\030 \024\023\036\030\026)Tj 0 Tw (-)Tj 0.082 Tw T* (\006\017\005. \200)Tj /Span<>> BDC ( )Tj EMC (\017\f\f\035\036\007\024\r\026\027\017\017 \025\026\035\026\030\017 \017\ )Tj /Span<>> BDC ( )Tj EMC [(\f\024\026\r\021. \027\026\017\002\024\035\036\036 )0.5(\030\026\f)]TJ 0 Tw (-)Tj 0.043 Tw T* (\023\030\024\f\021\030\026\027\036\027\027\024\005 \023\030\024\006\036\007\ \031\030\024\005 \002\t\035\026 \215\217, \004\021\024 \026\027\026\035\024\ \020\017\004\027\024 )Tj 0.008 Tw T* (\027\026\001\036\n\031 \017\f\f\035\036\007\024\r\026\027\017\033 [5,7].\ \224\017\f\021\026 \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. \r\022\035\033\004\026\035\017 )Tj 0.099 Tw T* (\021\024\035\034\022\024 \023\026\006\017\036\027\021\024\r, \023\036\030\ \036\027\036\f\001\017\b \215\206, \023\024\f\022\024\035\034\022\031 \b\ \017\030\031\030)Tj 0 Tw (-)Tj 0.279 Tw T* [(\020\017\004\036\f\022\017\036 \220\021\026\023\t \023\024\r\024\035\016\ \035\017 )0.5(\f\030\026\r\027\017\r\026\021\034 \220\027\036\030\020\036\021\017\004\036\ )]TJ 0 Tw (-)Tj 0.127 Tw T* (\f\022\017\036 \031\f\021\030\024\005\f\021\r\026 \f)Tj /Span<>> BDC ( )Tj EMC (\021\024\004\022\017 \030\036\027\017\016 \017\b \f\023\024\f\024\002\027\ \024\f\021\017 \030\036)Tj 0 Tw (-)Tj -0.02 Tw T* (\026\021\034, \022\024\026\020\031\035\017\030\024\r\026\021\034 \017)Tj /Span<>> BDC ( )Tj EMC (\f\022\024\030\024\f\021\017 \007\017\f\f\036\022\006\017\017 \021\022\026\ \027\036\005 [5].)Tj 0.495 Tw T* (\200 \027\026\001\036\n \017\f\f\035\036\007\024\r\026\027\017\017 \024\023\ \036\030\026\021\017\r\027\t\036 \r\n\036\001\026\021\036\035\034)Tj 0 Tw (-)Tj 0.111 Tw T* (\f\021\r\026 \r\t\023\024\035\027\016\035\017\f\034 \027\036\f\022\024\035\ \034\022\017\n\017 \b\017\030\031\030\020\026\n\017 \f)Tj /Span<>> BDC ( )Tj EMC (\030\026\027\t\n )Tj 0.005 Tw T* (\031\030\024\r\027\036\n \024\023\t\021\026. \200)Tj /Span<>> BDC ( )Tj EMC (\017\f\f\035\036\007\024\r\026\027\017\016\b, \023\030\024\r\036\007\036\ \027\027\t\b \224\017\f\021\026 )Tj 0.088 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC 0.838 0 Td [(\f\024\026\r\021. )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 3.709 0 Td [(\217\017\n\024\027\007\024\005 )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC 5.283 0 Td [(\f\024\026\r\021., )0.5(\b\017\030\031\030\020\017\004\036\f\022\017\036 )0.6(\024\023\036\030\026)]TJ 0 Tw (-)Tj 0.093 Tw -9.83 -1.218 Td [(\006\017\017 )0.5(\002\t\035\017 )0.5(\f\021\026\027\007\026\030\021\017\017\030\024\r\026\027\t )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 13.639 0 Td [(\r\t\023\024\035\027\016\035\017\f\034 )0.6(\027\026\027\026)]TJ 0 Tw (-)Tj -13.639 -1.218 Td (\004\036\027\027\t\n\017 \b\017\030\031\030\020\026\n\017 [5,6].)Tj 0.002 Tc 0.124 Tw 23.244 17.049 Td (\236\f\f\035\036\007\024\r\026\027\017\036 \025\026\035\026\030\017 \017\ )Tj /Span<>> BDC ( )Tj EMC [(\f\024\026\r\021. \r\022\035\033\004\026\035\024 \023\026\006\017\036\027\ \021\024\r)2( )]TJ 0.251 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC 0.924 0 Td [(\007\024\022\026\026\027\027\t\n )0.6(\035\024\022\026\004\036\f\021\r\036\027\027\t\n )0.6(\027\024\r\024\024\002\030\026\024\r\026\027\017\036\n)2( )]TJ 0.28 Tw -0.924 -1.218 Td (\021\024\035\f\021\024\005 \017)Tj /Span<>> BDC ( )Tj EMC [(\023\030\016\n\024\005 \022\017\001\022\017, \021\024\020\007\026 \022\026\ \022 \017\f\f\035\036\007\024\r\026\027\017\036)2( )]TJ 0.114 Tw T* (\224\017\f\021\026 \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. \r\022\035\033\004\026\035\024 \023\026\006\017\036\027\ \021\024\r \021\024\035\034\022\024 \f)Tj /Span<>> BDC ( )Tj EMC (\024\023\031\b\024)Tj 0 Tc 0 Tw (-)Tj 0.002 Tc 0.003 Tw T* (\035\034\033 \023\030\026\r\024\005 \023\024\035\024\r\017\027\t \021\024\ \035\f\021\024\005 \022\017\001\022\017. \210\023\036\030\026\006\017\016\ \023\030\024)Tj 0 Tc 0 Tw (-)Tj 0.002 Tc 0.203 Tw T* (\r\024\007\017\035\026\f\034 \r)Tj /Span<>> BDC ( )Tj EMC (\f\024\024\021\r\036\021\f\021\r\017\017 \f)Tj /Span<>> BDC ( )Tj EMC (\024\027\022\024\035\024\020\017\004\036\f\022\017\n\017 \023\030\017\027\ )Tj 0 Tc 0 Tw (-)Tj 0.002 Tc 0.353 Tw T* [(\006\017\023\026\n\017. \225\021\024 \024\002\036\f\023\036\004\017\r\026\ \035\024 \036\007\017\027\024\024\002\030\026\017\036 \021\036\b\027\017\ \022\017)2( )]TJ -0.006 Tw T* (\023\030\024\r\036\007\036\027\017\016 \023\030\024\006\036\007\031\030\t\ . \025\026\035\026\030\017 \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. \021\026\022\032\036 \r\022\035\033)Tj 0 Tc 0 Tw (-)Tj 0.002 Tc 0.041 Tw T* [(\004\026\035\017 \007\r\031\b\035\036\021\027\017\005 \023\036\030\017\024\ \007 \027\026\002\035\033\007\036\027\017\016 \007\035\016 \r\t\016\r\035\ \036\027\017\016)2( )]TJ 0.058 Tw T* (\030\036\006\017\007\017\r\026. \200)Tj /Span<>> BDC ( )Tj EMC (\027\026\001\036 \017\f\f\035\036\007\024\r\026\027\017\036 \002\t\035\017\ \r\022\035\033\004\036\027\t \007\024)Tj 0 Tc 0 Tw (-)Tj 0.002 Tc 0.391 Tw T* [(\002\030\024\022\026\004\036\f\021\r\036\027\027\t\036 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 9.033 0 Td [(\035\024\022\026\004\036\f\021\r\036\027\027\t\036 )0.5(\026\002\024\035\036\r\026\027\017\016)2.1( )]TJ 0.043 Tw -9.033 -1.218 Td [(\021\024\035\f\021\024\005 )0.5(\022\017\001\022\017, )0.5(\007\035\017\021\036\035\034\027\024\036 )0.5(\027\026\002\035\033\007\036\027\017\036 )0.5(\027\036 )0.5(\023\030\024\r\024\007\017)]TJ 0 Tc 0 Tw (-)Tj 0.002 Tc T* (\035\024\f\034 [6,7].)Tj 0 Tc 0.681 Tw T* (\200 \017\f\f\035\036\007\024\r\026\027\017\016\b \217\017\n\024\027\007\ \t \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021., \026)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\032\036 )Tj 0.202 Tw T* (\025\026\035\026\030\017 \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. \027\036 \031\004\017\021\t\r\026\035\f\016 \024\002\255\ \201\n \024\021\007\036\035\016\036\n\024\020\024 )Tj ET q 42.52 90.17 221.102 234.607 re W n q /GS0 gs 221.1023611 0 0 234.6077385 42.5196838 90.1700996 cm /Im0 Do Q Q BT 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0 Tw 9 0 0 9 42.5197 79.3701 Tm (\022\t\217\210\b\002\220 3.)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf ( \r\034\027\022\005\016\024\035\036\034 \034\035\b\016\027\030\016\006\034\ \013\034 \f\034)Tj /Span<>> BDC ( )Tj EMC (\b\033\016\020\037\201\023. )Tj ET q /GS0 gs 221.102346 0 0 230.0057967 274.9606356 90.1700965 cm /Im1 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 9 0 0 9 274.9606 79.3701 Tm (\022\t\217\210\b\002\220 4.)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf ( \t\034\024\027\016\034\f\016\033\037\007\022\034\020\020\032\004 \021\034\ \004\021\034-\b\016\020\003. )Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf -25.827 72.346 Td (\020\004\206\f\t\204\004 3.)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf ( \207\033\037\036\020\016\020\022\016 \033\016\031\023\027\003\035\037\035\ \034\036 \022\024\024\027\016\b\034\036\037\020\022\004)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf -0.027 Tc 0.027 Tw 0 -1.2 TD [(T)0.5(a)-35.3(b)-40.7(l)-38.7(e)-27( 3)-18.8(.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf 0 Tc 0 Tw 3.318 0 Td [( C)1.2(o)-4(m)-1(p)-6.3(a)-4.2(r)-38.9(i)6.6(s)0.5(o)-4(n o)4(f)]TJ /Span<>> BDC ( )Tj EMC [(s)-12.5(i)4(m)1.3(i)2.9(l)-1.1(a)-4.2(r s)-14.8(t)-1(u)-5.9(d)-3(i)-1.4(e)-22(s)]TJ ET 0 0 0 1 K 0.5 w /GS2 gs q 1 0 0 1 42.5197 715.181 cm 0 0 m 73.951 0 l S Q q 1 0 0 1 42.7697 694.3618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 116.4705 715.181 cm 0 0 m 46.772 0 l S Q q 1 0 0 1 116.4705 694.3618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 163.2421 715.181 cm 0 0 m 46.772 0 l S Q q 1 0 0 1 210.0138 715.181 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 210.0138 694.3618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 255.3681 715.181 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 300.7224 715.181 cm 0 0 m 46.772 0 l S Q q 1 0 0 1 300.7224 694.3618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 347.4941 715.181 cm 0 0 m 46.772 0 l S Q q 1 0 0 1 394.2657 715.181 cm 0 0 m 51.024 0 l S Q q 1 0 0 1 394.2657 694.3618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 445.2894 715.181 cm 0 0 m 51.274 0 l S Q q 1 0 0 1 496.313 694.3618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 42.5197 694.1118 cm 0 0 m 73.951 0 l S Q q 1 0 0 1 42.7697 673.3005 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 116.4705 694.1118 cm 0 0 m 46.772 0 l S Q q 1 0 0 1 116.4705 673.3005 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 163.2421 694.1118 cm 0 0 m 46.772 0 l S Q q 1 0 0 1 210.0138 694.1118 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 210.0138 673.3005 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 255.3681 694.1118 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 300.7224 694.1118 cm 0 0 m 46.772 0 l S Q q 1 0 0 1 300.7224 673.3005 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 347.4941 694.1118 cm 0 0 m 46.772 0 l S Q q 1 0 0 1 394.2657 694.1118 cm 0 0 m 51.024 0 l S Q q 1 0 0 1 394.2657 673.3005 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 445.2894 694.1118 cm 0 0 m 51.274 0 l S Q q 1 0 0 1 496.313 673.3005 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 42.5197 673.0505 cm 0 0 m 73.951 0 l S Q q 1 0 0 1 42.7697 661.8392 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 116.4705 673.0505 cm 0 0 m 46.772 0 l S Q q 1 0 0 1 116.4705 661.8392 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 163.2421 673.0505 cm 0 0 m 46.772 0 l S Q q 1 0 0 1 210.0138 673.0505 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 210.0138 661.8392 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 255.3681 673.0505 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 300.7224 673.0505 cm 0 0 m 46.772 0 l S Q q 1 0 0 1 300.7224 661.8392 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 347.4941 673.0505 cm 0 0 m 46.772 0 l S Q q 1 0 0 1 394.2657 673.0505 cm 0 0 m 51.024 0 l S Q q 1 0 0 1 394.2657 661.8392 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 445.2894 673.0505 cm 0 0 m 51.274 0 l S Q q 1 0 0 1 496.313 661.8392 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 661.5892 cm 0 0 m 73.951 0 l S Q q 1 0 0 1 42.7697 640.778 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 116.4705 661.5892 cm 0 0 m 46.772 0 l S Q q 1 0 0 1 116.4705 640.778 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 163.2421 661.5892 cm 0 0 m 46.772 0 l S Q q 1 0 0 1 210.0138 661.5892 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 210.0138 640.778 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 255.3681 661.5892 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 300.7224 661.5892 cm 0 0 m 46.772 0 l S Q q 1 0 0 1 300.7224 640.778 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 347.4941 661.5892 cm 0 0 m 46.772 0 l S Q q 1 0 0 1 394.2657 661.5892 cm 0 0 m 51.024 0 l S Q q 1 0 0 1 394.2657 640.778 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 445.2894 661.5892 cm 0 0 m 51.274 0 l S Q q 1 0 0 1 496.313 640.778 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 42.5197 640.528 cm 0 0 m 73.951 0 l S Q q 1 0 0 1 42.7697 619.7167 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 116.4705 640.528 cm 0 0 m 46.772 0 l S Q q 1 0 0 1 116.4705 619.7167 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 163.2421 640.528 cm 0 0 m 46.772 0 l S Q q 1 0 0 1 163.2421 619.7167 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 210.0138 640.528 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 210.0138 619.7167 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 255.3681 640.528 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 255.3681 619.7167 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 300.7224 640.528 cm 0 0 m 46.772 0 l S Q q 1 0 0 1 300.7224 619.7167 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 347.4941 640.528 cm 0 0 m 46.772 0 l S Q q 1 0 0 1 347.4941 619.7167 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 394.2657 640.528 cm 0 0 m 51.024 0 l S Q q 1 0 0 1 394.2657 619.7167 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 445.2894 640.528 cm 0 0 m 51.274 0 l S Q q 1 0 0 1 445.2894 619.7167 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 496.313 619.7167 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 42.5197 619.4667 cm 0 0 m 73.951 0 l S Q q 1 0 0 1 42.7697 598.6554 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 116.4705 619.4667 cm 0 0 m 46.772 0 l S Q q 1 0 0 1 116.4705 598.6554 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 163.2421 619.4667 cm 0 0 m 46.772 0 l S Q q 1 0 0 1 163.2421 598.6554 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 210.0138 619.4667 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 210.0138 598.6554 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 255.3681 619.4667 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 255.3681 598.6554 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 300.7224 619.4667 cm 0 0 m 46.772 0 l S Q q 1 0 0 1 300.7224 598.6554 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 347.4941 619.4667 cm 0 0 m 46.772 0 l S Q q 1 0 0 1 347.4941 598.6554 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 394.2657 619.4667 cm 0 0 m 51.024 0 l S Q q 1 0 0 1 394.2657 598.6554 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 445.2894 619.4667 cm 0 0 m 51.274 0 l S Q q 1 0 0 1 445.2894 598.6554 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 496.313 598.6554 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 42.5197 598.4054 cm 0 0 m 73.951 0 l S Q q 1 0 0 1 42.7697 577.5941 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 116.4705 598.4054 cm 0 0 m 46.772 0 l S Q q 1 0 0 1 116.4705 577.5941 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 163.2421 598.4054 cm 0 0 m 46.772 0 l S Q q 1 0 0 1 163.2421 577.5941 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 210.0138 598.4054 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 210.0138 577.5941 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 255.3681 598.4054 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 255.3681 577.5941 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 300.7224 598.4054 cm 0 0 m 46.772 0 l S Q q 1 0 0 1 300.7224 577.5941 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 347.4941 598.4054 cm 0 0 m 46.772 0 l S Q q 1 0 0 1 347.4941 577.5941 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 394.2657 598.4054 cm 0 0 m 51.024 0 l S Q q 1 0 0 1 394.2657 577.5941 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 445.2894 598.4054 cm 0 0 m 51.274 0 l S Q q 1 0 0 1 445.2894 577.5941 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 496.313 577.5941 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 42.5197 577.3441 cm 0 0 m 73.951 0 l S Q q 1 0 0 1 42.7697 566.1328 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 116.4705 577.3441 cm 0 0 m 46.772 0 l S Q q 1 0 0 1 116.4705 566.1328 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 163.2421 577.3441 cm 0 0 m 46.772 0 l S Q q 1 0 0 1 163.2421 566.1328 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 210.0138 577.3441 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 210.0138 566.1328 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 255.3681 577.3441 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 255.3681 566.1328 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 300.7224 577.3441 cm 0 0 m 46.772 0 l S Q q 1 0 0 1 300.7224 566.1328 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 347.4941 577.3441 cm 0 0 m 46.772 0 l S Q q 1 0 0 1 347.4941 566.1328 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 394.2657 577.3441 cm 0 0 m 51.024 0 l S Q q 1 0 0 1 394.2657 566.1328 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 445.2894 577.3441 cm 0 0 m 51.274 0 l S Q q 1 0 0 1 445.2894 566.1328 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 566.1328 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 565.8828 cm 0 0 m 73.951 0 l S Q q 1 0 0 1 42.7697 545.0715 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 116.4705 565.8828 cm 0 0 m 46.772 0 l S Q q 1 0 0 1 116.4705 545.0715 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 163.2421 565.8828 cm 0 0 m 46.772 0 l S Q q 1 0 0 1 163.2421 545.0715 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 210.0138 565.8828 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 210.0138 545.0715 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 255.3681 565.8828 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 255.3681 545.0715 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 300.7224 565.8828 cm 0 0 m 46.772 0 l S Q q 1 0 0 1 300.7224 545.0715 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 347.4941 565.8828 cm 0 0 m 46.772 0 l S Q q 1 0 0 1 347.4941 545.0715 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 394.2657 565.8828 cm 0 0 m 51.024 0 l S Q q 1 0 0 1 394.2657 545.0715 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 445.2894 565.8828 cm 0 0 m 51.274 0 l S Q q 1 0 0 1 445.2894 545.0715 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 496.313 545.0715 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 42.5197 544.8215 cm 0 0 m 73.951 0 l S Q q 1 0 0 1 116.4705 544.8215 cm 0 0 m 46.772 0 l S Q q 1 0 0 1 163.2421 544.8215 cm 0 0 m 46.772 0 l S Q q 1 0 0 1 210.0138 544.8215 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 255.3681 544.8215 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 300.7224 544.8215 cm 0 0 m 46.772 0 l S Q q 1 0 0 1 347.4941 544.8215 cm 0 0 m 46.772 0 l S Q q 1 0 0 1 394.2657 544.8215 cm 0 0 m 51.024 0 l S Q q 1 0 0 1 445.2894 544.8215 cm 0 0 m 51.274 0 l S Q BT /GS1 gs /T1_1 1 Tf 8 0 0 8 54.7923 701.7465 Tm (\034\217\217\f\r\240\002\004\b\t\r)Tj 11.106 0.6 Td (Kalari et al.)Tj 1.706 -1.2 Td (RCT)Tj 10.025 1.2 Td (Sista et al.)Tj 1.491 -1.2 Td (RCT)Tj 9.203 1.2 Td (Rimonda et al.)Tj 2.312 -1.2 Td (RCT)Tj 10.117 0.6 Td (Current study)Tj /T1_0 1 Tf -47.109 -2.033 Td (\200\030\036\n\016 \017\f\f\035\036\007\024\r\026)Tj (-)Tj T* (\027\017\016)Tj 12.581 1.2 Td (Pune 2022)Tj 11.577 0 Td (Italy 2013)Tj 11.516 0 Td (Italy 2009)Tj 13.287 0 Td (2022)Tj -48.961 -2.633 Td (\200\t\002\024\030\022\026)Tj 14.205 0 Td (50)Tj 11.266 0 Td (211)Tj 11.516 0 Td (140)Tj 12.474 0 Td (68)Tj -49.461 -1.433 Td (\210\023\036\030\026\006\017\016)Tj 11.68 0 Td (\215\206, \214\206, \215\217, \207\215\225)Tj 14.022 0 Td (\215\206)Tj 7.207 0 Td (\214\026\023\026\030\024\f\022\024\023\017\004\036\f\022\026\016 \215\206\ , )Tj 3.552 -1.2 Td (\214\206, \215\217)Tj 10.818 1.2 Td (\215\206, \214\206, \215\217, \224\225)Tj -47.281 -2.633 Td (\225\027\036\030\020\036\021\017\004\036\f\022\024\036 )Tj T* (\031\f\021\030\024\005\f\021\r\024)Tj 9.363 1.2 Td (Bipolar \(25\))Tj 6.211 0 Td (Ultrasonic )Tj -0.321 -1.2 Td (scalpel \(25\))Tj 6.073 1.2 Td (NUS \(108\))Tj 5.953 0 Td (CH \(103\))Tj 5.34 0 Td (Ultracision )Tj 1.323 -1.2 Td (\(70\))Tj 4.992 1.2 Td (LigaSure)Tj 0.854 -1.2 Td (\(70\))Tj 5.521 1.2 Td (EC \(31\))Tj 6.324 0 Td (US \(37\))Tj -51.635 -2.633 Td (\200\030\036\n\016 \024\023\036\030\026\006\017\017 )Tj T* (\(\n\017\027\031\021\t\))Tj 9.253 1.2 Td (175.6)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (27.4)Tj 6.244 0 Td (137)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (26.7)Tj 6.156 0 Td (103)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (21)Tj 5.669 0 Td (131)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (27)Tj 4.962 0 Td (114.8)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (47.6)Tj 5.846 0 Td (116.3)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (44.0)Tj 6.112 0 Td (270.8)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (95.5)Tj 6.128 0 Td (280.7)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (101.5 )Tj -50.371 -2.633 Td (\236\027\021\030\026\024\023\036\030\026\006\017\024\027\027\026\016 )Tj T* (\022\030\024\r\024\023\024\021\036\030\016 \(\n\035\))Tj 9.253 1.2 Td (271.8)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (80.6)Tj 6.244 0 Td (184)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (68.1)Tj 7.317 0 Td (NA)Tj 5.669 0 Td (NA)Tj 3.8 0 Td (107.9)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (42.0)Tj 5.846 0 Td (111.2)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (51.5)Tj 5.862 0 Td (219.4)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (150.4)Tj 6.378 0 Td (275.4)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (265.4)Tj -50.371 -2.633 Td (\025\024\005\022\024-\007\036\027\034 )Tj 9.577 0 Td (12.3)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (-2.6)Tj 6.272 0 Td (9.7)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (2.2)Tj 7.287 0 Td (8)Tj 5.419 0 Td (11)Tj 4.479 0 Td (7.4)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (2.2)Tj 5.846 0 Td (6.9)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (3.3)Tj 6.112 0 Td (7.2)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (1.9)Tj 6.378 0 Td (7.6)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (3.1)Tj -51.371 -1.433 Td (\210\021\007\036\035\016\036\n\024\036 \023\024)Tj /Span<>> BDC ( )Tj EMC (\007\030\036)Tj (-)Tj T* (\027\026\032\031 \(\n\035\))Tj 11.21 1.2 Td (NA)Tj 5.846 0 Td (NA)Tj 3.92 0 Td (D1:125)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (40)Tj 0.25 -1.2 Td (D2:70)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (30)Tj 5.419 1.2 Td (D1:155)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (50)Tj T* (D2:110)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (35)Tj 7.595 1.2 Td (NA)Tj 5.846 0 Td (NA)Tj 4.155 0 Td (148.7)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (63.9)Tj 7.174 0 Td (149)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (51)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\034\201\025\b\222\016\017)-9.9(\026\021\r\215\025\016 \025\211\215\025\212\016\215\026\201\025\r\025\016\ \215\001\235\t\205\211\001\026)11(\016\t\214\215\025\016 \021\b\b)-10(\t\016\211\025\r\001\215\021\016 )]TJ 0 -1 TD [(\242\215\016\201\202)10(\016\026\021\f\016\b\017\021 \200\b)-10(\026\201\025\207\b)-10(\026\r \r\022\017)10(\025\t\025\201\016\017)-10(\026)11(\001\t\214\215\025\207 \021\201\200\201\202\021\021)]TJ 41.119 1 Td [(A Pr)20(ospectiv)12(e Single Centr)31(e Obser)-20.9(v)10(ational Study )]TJ 3.383 -1 Td [(on\022Ener)31.1(gy\022De)11(vices in Color)31(ectal Sur)31(ger)-31(y)]TJ -44.502 96.622 Td [(\036\033\030\031\030\217\n)-20.9(\035\210\217\241\003 \013\032)50(\n)42(\032\210\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj /T1_4 1 Tf 25 0 0 25 504.7145 56.0378 Tm (117)Tj ET endstream endobj 1600 0 obj <>stream Adobed     '$''''$25552;;;;;;;;;;   ####''',,,   ####''',,,   ####''',,,""    i !1345AQRst"Sa2Tq#BCDUbc $%&'()*6789:EFGHIJVWXYZdefghijruvwxyz}!1A"BaQq2RSbr#$4C %&'()*356789:DEFGHIJTUVWXYZcdefghijstuvwxyz?@jIW&cl*55l;.OqG@ UݚZ*R9 )ZX,v嫈V];Wt^ȴHN"bjWQmL@|CXM従QW*[-[}gۅԞ(4RU_Io/ϭ5d5{U4&6;]3UUy1.2D^PG^ئ%r11ίQ[n` Іx*Y$*f5Euۖւ2VXg}Bы$\Hdbճɸtչ9i֧ZZh} ߁[>|n^;ySyիh5rnJ9iե}jЫ㲭clz`HTTTTKrWWL[%Vb7=[nTKqkl&C W} 8uzi>)>'rRkrI+QU}Gܨ4xxmʇ&A Ώ PhەX Lɐ<ە P0Ώ PhەX Lɐ<ە P]t.uk_,p6G+Xj5!A/}>ɴpٰ1qێj))ʿ@ =r*ioeí=: 8 D'*l_l9WbagnT<<6B=: 8IUG_ TѽDTGZ D'*l_l$%<,HU.VW$զnT<<6Cw ndXnT<<6Cw nd:<<6AnT=`7y2 &@nT<<6Cw nd:<<6AnT=`7y2 &@nT<<6Cw nd:<<6AnT=`7y2 &@nT<<6Cw nd:<<6AnT=`7y2 &@nT<<6Cw nd:<<6AnT=y20Ώ PhەX Lɐ<ە P0Ώ PhەX Lɐ<ە P0Ώ P#z"-ɐjj" }@.O ]4b4 HG _0_r"$k509JK{߅ 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neZ-VJTzݬVJRUTi5Pz>(eZ9q\}>1u ve<z޷/})jmy7=d,lZzF:1jӊ- %|SݥӭF5U6k=4v.]X=z(\hC<Dlg'9Ad q,'Va= qO4NDlg'GA pUOCEMwq4Arzo|wtAdMwq_|1[8*]>Dlg'9Ad q,'Va= qO4NDlg'GA pUOCEMwq4Arzo|wtAdMwq_|1[8*]>Dlg'9Ad q,'Va= qO4NDlg'GA pUOCEMwq4Arzo|wtAdMwq_|1[8*]>Dlg'9Ad q,'Va= qO4NDlg'GA pUOCEMwq4Arzo|wtAdMwq_|1[8*]>Dlg'9Ad q,'Va= qO4NDlg'GA pUOCEMwq4Arzo|wtAdMwq_|1[8*]>Dlg'9Ad q,'Va= qO4NDlg'GA pUOCEMwq4Arzo|wk*ffpm&K+bq?׵Q" """ (cs=,mtlALKfsK^KA*+C6a,f<49ywExgXSJU6UsUK8{#Л eSMTZlNLQ`I0RuT]mWe+bm3JR]hk촴gDF 5ԳQW2H16h.F6g 3cMvC!I,Z5ڛ U2I4걥8il⸥Nd3+m4MX8uK})I㦛{+*llUZSViKs *(xNpNI*UM DP%u阻 a*5 :x#[%ym.hۮ+ 3-DqeEA{!7t.euz F,,>8 ht4፽zKKNK\MwQJ$rQ ]kmd(/9+;<kUt:U u+ T೭ǬkUV6*l;*Ku:i`ܣە+)XIҦ6M*#I)Y2Z֗[%[WjvH‹JmbÓFSO%E9cv6-x,unL6'u%젌˃lD9sP"f]dH&'Ql8.ZI)*2ccCn .#YHk:YUTV:cfn^MuqvtU]4YUUnD7VEJM&&BU96N%/)U4%sMKi&eW;4KR=Ұ>N6\Eޢ aazPED}αEl8طˋr=?`Țm(%r1rARVԊL^cm]б ;tl)JSToutZYեTUNqVzͬYm-mj%E4˵ͪ۩8SM,b(ƕE[Lu+zJ-J*ּ*eM4Sc쮬'UU6u* &$4du5 5LP.́u5kz=t jAUtY|:֋\LsM\"F-X r nJ< S& 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MiԩҪaMU*ié:tڦwb=.):UkEk%:٭TkVuplmM4Z+Vthfu%[mgRtU7gKmmBaf8O#$'E䑦7\7EeѠµ0M#gtUE-Mu,2 y\,$L1׌Uf "guA&VQ]6V,ZцkST'rmYXJ5YxuYYVooF ֺi@#@Xh+`s%sO4Cl tNG51^b"(3K07 ì|SZvj[ҥʻ+J-Uխ1iU4X1s*5cuP4kZv,mkbP(^k:Z,,)❬̬5< ҋݧK]MЮ= /3GU[-,!iCÝVg95y7r[a"hS8*"#&G]y-w6 - p}n.XMkEcMSֳƊ-JhZVԓjªf]lEfvvVYYpmhfɤt.x;x""ӵQ" =Ή7#.t,qe[:XihMQd W#YfROU;ZBҵkJ:)$hXܥgAVT[֋wmdk=t*uͅ6KpHVV`z:$8mג[XRz*J-FրX-pt4/1X X])18벋t{u744x.zfH)#scHKA/AUiekoamgiMV[Y7gRtn<@IOL؛p`٤hWd 4u 4]J%^ +yFգ `jiCkݑώw5֒mm΂ ![UVku>vZkajpTU4f =SR1;EϤY5qPkz쫶Vhzf鱦֝ѪF$ڙkMk]g֪m5)S)uUxVt[k5PthV=eLe\n9᠇ NWNiD))j[#Y`냝=*bM}0eȪP @vMrCS΋4OuFGY* +%fdiPJhui,XM6X_֬Zj5XYeEVT:vtEX6VZM[ZqWiuZE`#ۊ׊֚ۊ՝8%UVjQ/tw,Q[̟6y2h.Pttpx4Aw33\f XH)ɓEoQ&і&.k sEh!mз.$֛-i[kkJpͬե:6Tں)Ke!\ΌޚU \8Zb>[5ZRzXir 7VvN+Jkn%Cu8M4V6\SjvaUzMUfWeNt*0kOfH`kDMl`Hp8]6:j75Q ׻uX50pjO2G@/tm$h ){_KRVYXNA茢+*Unު[J۩ԡwں$kZZ5Ym]auS^ TQ8S}j*tlUk˭UcjkmMy`V(\Tun*UuZ[5k5y18v6ur5Mx.V)=[ckZ-4f.mM ͦ86%~i#"};M1a:TcaRф(uU}g,>ZyC/4Ev4MB'wߧ~n-`w;({b)ּTm]M4eo[tB,m-[W'R=+6-aZ6\ۊYMJgcfp*_;.*vZu*-֪Z*w<&3D9STJj 3J 5 `hۓ\a8;tugI{3$cCn(+[%e<mF2MS7M2YnKlY-O3)* YmM; oFLE~*UFY:eʼ coZ}yu7 |ZW4֫ v=Y;L:)vJՅ]Vx#~*FYk-QV+Z,Un´mi׊pd٧aඎhak=a֪Z=iv1VzP]3(D.pzA4ߘfwys5ix {㣑K+e l&aK`=inr(|ּg+^mmf׳ٓ|`YUo`hu]Kk-ǻ;Zuk%YiUU^,굵U%Uv8.qYYⳬ=iZiNJ[;:eYJX:I+Z)C9Wh#!MܝE?3̚!k. }bT0]CeiӄaVdsÚC,Zu SLA0l:k[N{u^V-f s~흖[+WoB00*>*5zM.)v5kM6T]`vZS*VgM:њY)gE8mӚ뛮V,*Z$*xaAɓTsa&G11$RNȘHG\ܖn[*ᅸNH3@ Cˠ,Il%D"ts7 W486CR-+YXZUV٧EuYtMmRqЕM7 [l5mvJYk=vέxS]SJ/NZ?ZuZzѬ`UnTkM6R¥KrgoVbvuNicW~)vVnvKX괢USU6',րnwG^¹{bssS.{omoTT/ 4TTR\X\]%ͼ,:u1f -,Ε 5$c=&>f:F.ʋzbVNT*:5Uk]-SMX*('P}-ֶQY6keziSMjFTVI%* [ze[gcTUkvm`t]5fu%M-WgL^ԩmDٜ y ٔng)dl'^) ;:,B8o4cUj=G9~ sb sA5^CNF]lIujʊmV44Ua4OeNxzgKgQKybRׁR[TbGO%ikʦe:M֊tMS S\uE6|UiiE4kVfvUkK [.d#mdֆ5AZjbo汈\8k@aHɧM {p/`65ӕYb%TW4T>)/Sel&4t>rMl**u:ws4&IƲZWcn֍c[mJiꦪRW_4wK*+~)V6f+ZZե3]4UMRhtze+MhXluZVgkevnӅM8r+ԩLKMI!nn؜ {=.3eiAy]IIX Nq 3#_$5NZ<_ⱭͮZP]6jEUcu)QUu8wDDXֽQaY"sʺ-(qUJ\'R\N8M%=Y3KZ\\o98K\znD@XֽlLZ*UTT(SN%MtE*%{o+D@DDD@tEd⢥{a-$:ᵷD. eⱭb5(ү1vU^фx5" 54[}iniF r"YuX¼ 겴n[%.̚Y/:" """ """ endstream endobj 1611 0 obj <>stream xmp.did:24B99F99239EF011AD90A7A73F66EDFC xmp.did:28B99F99239EF011AD90A7A73F66EDFC endstream endobj 1610 0 obj <>stream xmp.did:28B99F99239EF011AD90A7A73F66EDFC endstream endobj 1596 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.125 Tw 10 0 0 10 70.8661 590.8719 Tm [(\007\036\030\017\r\026\006\017\024\027\027\026\016 )0.6(\f\021\024\n\026, )0.5(\r\f\036 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 12.691 0 Td [(\022\024\021\024\030\t\b )0.5(\023\030\036\007\f\021\026\r\035\016\035\017 )]TJ 0 Tw -12.691 -1.218 Td (\f\024\002\024\005 \023\036\021\035\036\r\t\036 \017\035\036\024\f\021\024\ \n\t.)Tj 0.56 Tw 0 -1.218 TD (\203\026\017\002\024\035\036\036 \004\026\f\021\t\n \023\024\022\026\026\ \027\017\036\n \022)Tj /Span<>> BDC ( )Tj EMC (\b\017\030\031\030\020\017\004\036\f\022\024\n\031 )Tj 0.573 Tw 0 -1.218 TD (\r\n\036\001\026\021\036\035\034\f\021\r\031 \002\t\035\017 \035\024\022\ \026\004\036\f\021\r\036\027\027\t\036 \027\024\r\024\024\002\030\026)Tj 0 Tw (-)Tj 0.2 Tw T* (\024\r\026\027\017\016 \021\024\035\f\021\024\005 \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\016\n\024\005 \022\017\001\022\017. \230\024\035\034\022\024 6)Tj /Span<>> BDC ( )Tj EMC (\(8,8%\) )Tj 0.31 Tw T* (\024\023\036\030\026\006\017\005 \002\t\035\017 \r\t\023\024\035\027\036\ \027\t \023\024)Tj /Span<>> BDC ( )Tj EMC (\023\024\r\024\007\031 \007\024\002\030\024\022\026\004\036)Tj 0 Tw (-)Tj 0.333 Tw T* [(\f\021\r\036\027\027\t\b \026\002\024\035\036\r\026\027\017\005. )0.5(\203\026\017\002\024\035\036\036 \004\026\f\021\024\005 \035\024\022\026\ \004\036)]TJ 0 Tw (-)Tj 0.513 Tw T* (\f\021\r\036\027\027\024\005 \020\017\f\021\024\023\026\021\024\035\024\020\ \017\036\005 \002\t\035\026 \026\007\036\027\024\022\026\030\006\017\027\ \024\n\026, )Tj -0.012 Tw T* (\r\t\016\r\035\036\027\027\026\016 \r)Tj /Span<>> BDC ( )Tj EMC (56)Tj /Span<>> BDC ( )Tj EMC (\(82,4%\) \f\035\031\004\026\016\b. \224\030\036\007\017 \007\030\031\020\ \017\b \026\002\024)Tj 0 Tw (-)Tj 0.111 Tw T* (\035\036\r\026\027\017\005 \002\t\035\017 \027\036\b\024\007\032\022\017\ \027\f\022\026\016 \035\017\n\235\024\n\026 \(\007\017\235\235\031\027\026\ \016 )Tj 0.286 Tw T* [(\200-\022\030\031\023\027\024\022\035\036\021\024\004\027\026\016 )0.6(\035\017\n\235\024\n\026\) )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 14.224 0 Td (\027\036\005\030\024\220\027\007\024\022\030\017\027\027\026\016 )Tj 0.358 Tw -14.224 -1.218 Td (\024\023\031\b\024\035\034. \236\031\004\026\036\n\t\n\017 \030\036\031\ \035\034\021\026\021\026\n\017 \002\t\035\017 \023\030\024\007\024\035)Tj 0 Tw (-)Tj 0.562 Tw T* (\032\017\021\036\035\034\027\024\f\021\034 \024\023\036\030\026\006\017\017\ \(\n\017\027\031\021\t\), \024\021\021\024\022 \007\030\036\027\026\032\ \026 )Tj 0.077 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\021\036\004\036\027\017\036 \023\036\030\r\t\b 48 \004\026\f\024\r \(\n\ \035\), \023\030\024\007\024\035\032\017\021\036\035\034\027\024\f\021\034\ )Tj 0.111 Tw T* (\023\030\036\002\t\r\026\027\017\016 \r)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\034\027\017\006\036 \(\007\027\017\) \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\007\024\035\032\017\021\036\035\034\027\024\f\021\034 )Tj 0.662 Tw T* (\023\030\036\002\t\r\026\027\017\016 \r)Tj /Span<>> BDC ( )Tj EMC (\024\021\007\036\035\036\027\017\017 \017\027\021\036\027\f\017\r\027\024\ \005 \021\036\030\026\023\017\017 )Tj 0.217 Tw T* (\(\007\027\017\), \022\026\022 \023\024\022\026\026\027\024 \r)Tj /Span<>> BDC ( )Tj EMC (\021\026\002\035\017\006\036 2. \224\030\036\007\027\016\016 \023\030\024\ \007\024\035)Tj 0 Tw (-)Tj 0.189 Tw T* (\032\017\021\036\035\034\027\024\f\021\034 \024\023\036\030\026\006\017\017\ , \022\026\022 \023\024\022\026\026\027\024 \027\026)Tj /Span<>> BDC ( )Tj EMC (\030\017\f\031\027\022\036 1, )Tj 0.134 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 EC \f\024\f\021\026\r\017\035\026 270,8)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (95,5 \n\017\027\031\021, \026)Tj /Span<>> BDC ( )Tj EMC (\r \020\030\031\023)Tj 0 Tw (-)Tj 0.108 Tw T* (\023\036 US)Tj /Span<>> BDC ( )Tj EMC (\227 280,7)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (101,5 \n\017\027\031\021. \203\026)Tj /Span<>> BDC ( )Tj EMC (\030\017\f\031\027\022\036 2 \023\024\022\026\026)Tj 0 Tw (-)Tj 0.137 Tw T* (\027\024, \004\021\024 \f\030\036\007\027\016\016 \022\030\024\r\024\023\ \024\021\036\030\016 \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 EC \f\024\f\021\026\r\017\035\026 )Tj 0.102 Tw 23.244 24.356 Td (219,4)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (150,4 \n\035, \026)Tj /Span<>> BDC ( )Tj EMC (\r \020\030\031\023\023\036 US)Tj /Span<>> BDC ( )Tj EMC (\227 275,4)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (265,4 \n\035. )Tj 0.281 Tw T* [(\224\030\036\007\027\036\036 )0.5(\027\026\004\036\027\017\036 )0.5(\024\021\021\024\022\026 \007\030\036\027\026\032\026 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC [(\021\036\004\036\027\017\036 )0.5(\023\036\030)]TJ 0 Tw (-)Tj 0.08 Tw 0 -1.218 TD (\r\t\b 48 \004\026\f\024\r \f\024\f\021\026\r\017\035\024 148,1)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (63,9 \n\035 \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 EC. )Tj 0.072 Tw 0 -1.218 TD (\200)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \224\221\202 \220\021\024\021 \023\024\022\026\ \026\021\036\035\034 \f\024\f\021\026\r\017\035 149)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (51)Tj /Span<>> BDC ( )Tj EMC (\n\035, )Tj 0.069 Tw T* (\004\021\024 \026\027\026\035\024\020\017\004\027\024 \023\030\036\007\f\ \021\026\r\035\036\027\024 \027\026)Tj /Span<>> BDC ( )Tj EMC (\030\017\f\031\027\022\036 3. \224\030\036\007\027\016\016 )Tj 0.139 Tw T* (\023\030\024\007\024\035\032\017\021\036\035\034\027\024\f\021\034 \023\030\ \036\002\t\r\026\027\017\016 \r)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\034\027\017\006\036 \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023)Tj 0 Tw (-)Tj 0.217 Tw T* (\023\036 \213\224 \f\024\f\021\026\r\017\035\026 7,2)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (1,9 \007\027\016, \026)Tj /Span<>> BDC ( )Tj EMC (\r \020\030\031\023\023\036 \224\221\202)Tj /Span<>> BDC ( )Tj EMC (\227 )Tj 0.196 Tw T* (7,6)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC 2.542 0 Td (3,1)Tj /Span<>> BDC ( )Tj EMC [(\007\027\016, )0.5(\004\021\024 )0.5(\026\027\026\035\024\020\017\004\027\024 )0.5(\023\030\036\007\f\021\026\r\035\036\027\024 )0.5(\027\026)]TJ /Span<>> BDC ( )Tj EMC 18.196 0 Td (\030\017)Tj 0 Tw (-)Tj 0.18 Tw -20.738 -1.218 Td (\f\031\027\022\036 4. \200)Tj /Span<>> BDC ( )Tj EMC (\027\026\001\036\n \017\f\f\035\036\007\024\r\026\027\017\017 \027\036 \002\ \t\035\024 \r\t\016\r\035\036\027\024 )Tj 0.059 Tw T* (\f\021\026\021\017\f\021\017\004\036\f\022\017 \027\026\004\017\n\024\005\ \030\026\027\017\006\t \n\036\032\007\031 \007\r\031\n\016 \020\030\031\ \023)Tj 0 Tw (-)Tj T* (\023\026\n\017 \023\024)Tj /Span<>> BDC ( )Tj EMC (\r\t\001\036\031\022\026\026\027\027\t\n \023\026\030\026\n\036\021\030\ \026\n.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 303.3769 432.5578 Tm [(\037\036)10(\032\223\212\226\034\022\031\034)]TJ 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0 Tc 0.126 Tw 10 0 0 10 303.3071 408.2018 Tm (\200 \021\026\002\035\017\006\036 3 \023\030\036\007\f\021\026\r\035\036\ \027\024 \f\030\026\r\027\036\027\017\036 \027\026\001\036\020\024 \f)Tj /Span<>> BDC ( )Tj EMC (\007\030\031)Tj 0 Tw (-)Tj 0.092 Tw T* [(\020\017\n\017 )0.5(\026\027\026\035\024\020\017\004\027\t\n\017 )0.5(\017\f\f\035\036\007\024\r\026\027\017\016\n\017, )0.6(\023\030\024\r\036\007\036\027\027\t\n\017 )]TJ 0.221 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC (\027\026\006\017\024\027\026\035\034\027\024\n \017)Tj /Span<>> BDC ( )Tj EMC 8.824 0 Td [(\n\036\032\007\031\027\026\030\024\007\027\024\n )0.5(\031\030\024\r\027\036. \200)]TJ /Span<>> BDC ( )Tj EMC (\027\036\005 )Tj 0.059 Tw -8.824 -1.218 Td (\023\030\036\007\f\021\026\r\035\036\027\t \017\031\004\036\027\027\t\036\ \220\027\036\030\020\036\021\017\004\036\f\022\017\036 \031\f\021\030\024\ \005\f\021\r\026 )Tj 0.126 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\023\026\030\026\n\036\021\030\t \030\036\031\035\034\021\026\021\024\r\ , \027\026\002\035\033\007\026\r\001\017\036\f\016 \r)Tj /Span<>> BDC ( )Tj EMC (\022\026\032\007\024\005 )Tj 0 Tw T* (\020\030\031\023\023\036.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 9 0 0 9 70.8661 730.483 Tm (\020\004\206\f\t\204\004 2.)Tj 0 0 0 1 k /GS1 gs /T1_3 1 Tf ( \200\024\002\034\b\032 \002\022\033\023\033\013\022\005\016\024\021\022\ \002 \036\006\016\001\037\035\016\027\003\024\035\036)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf -0.027 Tc 0.027 Tw 0 -1.2 TD [(T)0.5(a)-35.3(b)-40.7(l)-38.7(e)-27( 2)-34.3(.)]TJ 0 0 0 1 k /GS1 gs /T1_3 1 Tf 0 Tc 0 Tw 3.334 0 Td [( D)-12.1(i)6.6(s)-14.8(t)-9.5(r)-39(i)4.6(b)-1.5(u)-4.8(t)-29.1(i)-1.4(o)-4(n o)4.1(f)]TJ /Span<>> BDC ( )Tj EMC [(o)-3.3(u)-4.8(t)-3.4(c)2.8(o)-4(m)-5.3(e v)6.4(a)-4.2(r)-39(i)1.5(a)-0.9(b)-3.4(le)-22(s a)-5(m)-5.3(o)-4(n)-0.6(g t)-10.6(h)-2.4(e)]TJ /Span<>> BDC ( )Tj EMC [(t)-22.9(w)2.3(o g)-1.5(r)-2(o)-3.4(u)-2.3(p)1.8(s i)3.9(n t)-10.5(h)-2.4(e)]TJ /Span<>> BDC ( )Tj EMC [(s)-14.8(t)-1.1(u)-5.9(d)-7.2(y \()61.8(m)-5.3(e)-7.5(a)-5.1(n)64.8(\))]TJ ET 0 0 0 1 K 0.5 w /GS2 gs q 1 0 0 1 70.8661 715.181 cm 0 0 m 158.99 0 l S Q q 1 0 0 1 71.1161 703.7117 cm 0 0 m 0 11.219 l S Q q 1 0 0 1 229.8563 715.181 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 229.8563 703.9617 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 289.3839 715.181 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 348.9114 715.181 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 348.9114 703.9617 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 408.439 715.181 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 467.9666 715.181 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 467.9666 703.9617 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 524.6594 703.7117 cm 0 0 m 0 11.219 l S Q q 1 0 0 1 71.1161 692.4926 cm 0 0 m 0 11.219 l S Q q 1 0 0 1 229.6063 703.7117 cm 0 0 m 59.778 0 l S Q q 1 0 0 1 229.8563 692.4926 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 289.3839 703.7117 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 289.3839 692.4926 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 348.9114 703.7117 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 348.9114 692.4926 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 408.439 703.7117 cm 0 0 m 59.778 0 l S Q q 1 0 0 1 408.439 692.4926 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 467.9666 692.4926 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 524.6594 692.4926 cm 0 0 m 0 11.219 l S Q q 1 0 0 1 70.8661 692.2426 cm 0 0 m 158.99 0 l S Q q 1 0 0 1 71.1161 681.0312 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 229.8563 692.2426 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 229.8563 681.0312 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 289.3839 692.2426 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 289.3839 681.0312 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 348.9114 692.2426 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 348.9114 681.0312 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 408.439 692.2426 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 408.439 681.0312 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 467.9666 692.2426 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 467.9666 681.0312 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 681.0312 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 680.7812 cm 0 0 m 158.99 0 l S Q q 1 0 0 1 71.1161 669.5699 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 229.8563 680.7812 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 229.8563 669.5699 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 289.3839 680.7812 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 289.3839 669.5699 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 348.9114 680.7812 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 348.9114 669.5699 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 408.439 680.7812 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 408.439 669.5699 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 467.9666 680.7812 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 467.9666 669.5699 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 669.5699 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 669.3199 cm 0 0 m 158.99 0 l S Q q 1 0 0 1 71.1161 658.1087 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 229.8563 669.3199 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 229.8563 658.1087 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 289.3839 669.3199 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 289.3839 658.1087 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 348.9114 669.3199 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 348.9114 658.1087 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 408.439 669.3199 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 408.439 658.1087 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 467.9666 669.3199 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 467.9666 658.1087 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 658.1087 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 657.8587 cm 0 0 m 158.99 0 l S Q q 1 0 0 1 71.1161 646.6474 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 229.8563 657.8587 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 229.8563 646.6474 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 289.3839 657.8587 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 289.3839 646.6474 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 348.9114 657.8587 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 348.9114 646.6474 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 408.439 657.8587 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 408.439 646.6474 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 467.9666 657.8587 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 467.9666 646.6474 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 646.6474 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 646.3974 cm 0 0 m 158.99 0 l S Q q 1 0 0 1 71.1161 635.1861 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 229.8563 646.3974 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 229.8563 635.1861 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 289.3839 646.3974 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 289.3839 635.1861 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 348.9114 646.3974 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 348.9114 635.1861 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 408.439 646.3974 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 408.439 635.1861 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 467.9666 646.3974 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 467.9666 635.1861 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 635.1861 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 634.9361 cm 0 0 m 158.99 0 l S Q q 1 0 0 1 71.1161 623.7249 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 229.8563 634.9361 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 229.8563 623.7249 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 289.3839 634.9361 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 289.3839 623.7249 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 348.9114 634.9361 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 348.9114 623.7249 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 408.439 634.9361 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 408.439 623.7249 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 467.9666 634.9361 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 467.9666 623.7249 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 623.7249 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 623.4749 cm 0 0 m 158.99 0 l S Q q 1 0 0 1 229.8563 623.4749 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 289.3839 623.4749 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 348.9114 623.4749 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 408.439 623.4749 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 467.9666 623.4749 cm 0 0 m 56.943 0 l S Q BT /GS1 gs /T1_2 1 Tf 8 0 0 8 130.5425 700.8117 Tm (\200\002\220\004\213\004\003\r\f\001)Tj 15.595 0.717 Td (\222\f\r\220\003\006\002\220\002\004\n\210\f\235\204\t\235)Tj 16.176 0 Td (\224\033-\217\220\004\f\001\212\r\f\001)Tj 13.668 -0.717 Td (\022)Tj -31.08 -0.717 Td (\217\006\r\240\b\r\r)Tj 8.938 0 Td (\261)Tj /Span<>> BDC ( )Tj EMC 5.943 0 Td (\217\006\r\240\b\r\r)Tj 8.938 0 Td (\261)Tj /Span<>> BDC ( )Tj EMC /T1_0 1 Tf -45.253 -1.433 Td (\200\030\036\n\016 \024\023\036\030\026\006\017\017 \(\n\017\027\031\021\ \t\))Tj 22.116 0 Td (270,8)Tj 7.691 0 Td (95,5)Tj 7.191 0 Td (280,7)Tj 7.441 0 Td (101,5)Tj 7.264 0 Td (0,683)Tj -51.703 -1.433 Td (\236\027\021\030\026\024\023\036\030\026\006\017\024\027\027\026\016 \022\ \030\024\r\024\023\024\021\036\030\016 \(\n\035\))Tj 22.116 0 Td (219,4)Tj 7.441 0 Td (150,4)Tj 7.441 0 Td (275,4)Tj 7.441 0 Td (265,4)Tj 7.264 0 Td (0,301)Tj -51.703 -1.433 Td (\210\021\007\036\035\016\036\n\024\036 \023\024)Tj /Span<>> BDC ( )Tj EMC (\007\030\036\027\026\032\031 \(\n\035\))Tj 22.116 0 Td (148,1)Tj 7.691 0 Td (63,9)Tj 7.191 0 Td (149,0)Tj 7.691 0 Td (51,0)Tj 7.014 0 Td (0,947)Tj -51.703 -1.433 Td (\025\024\005\022\024-\007\036\027\034)Tj 22.616 0 Td (7,2)Tj 7.441 0 Td (1,9)Tj 7.441 0 Td (7,6)Tj 7.441 0 Td (3,1)Tj 6.764 0 Td (0,500)Tj -51.703 -1.433 Td (\025\024\005\022\024-\007\036\027\034 \r)Tj /Span<>> BDC ( )Tj EMC (\215\236\230)Tj 22.616 0 Td (2,0)Tj 7.441 0 Td (0,0)Tj 7.441 0 Td (3,6)Tj 7.441 0 Td (3,4)Tj 6.764 0 Td (0,681)Tj -51.703 -1.433 Td (\206\036\n\024\020\035\024\002\017\027)Tj 22.366 0 Td (0,15)Tj 7.441 0 Td (1,33)Tj 7.441 0 Td (0,61)Tj 7.441 0 Td (1,45)Tj 7.014 0 Td (0,179)Tj ET q 70.866 90.17 221.102 234.33 re W n q /GS0 gs 221.1023484 0 0 234.3306932 70.8661518 90.1701095 cm /Im0 Do Q Q BT 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 9 0 0 9 70.8661 79.3701 Tm (\022\t\217\210\b\002\220 1.)Tj 0 0 0 1 k /GS1 gs /T1_3 1 Tf ( \033\016\006\030 \034\f\016\033\037\007\022\022. )Tj ET q /GS0 gs 221.1023829 0 0 237.1686241 303.3070746 90.170085 cm /Im1 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 9 0 0 9 303.3071 79.3701 Tm 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[(\216\026\030\026\022\021\036\030\017\f\021\017\022\017 \b\017\030\031\030\ \020\017\004\036\f\022\024\020\024 \r\n\036\001\026\021\036\035\034\f\021\ \r\026)16( )]TJ 0.001 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\024\002\036\017\b \020\030\031\023\023\026\b \002\t\035\017 \f\b\024\032\ \017\n\017, \022\026\022 \023\024\022\026\026\027\024 \r)Tj /Span<>> BDC ( )Tj EMC (\021\026\002)Tj 0 Tc 0 Tw (-)Tj 0.016 Tc 0.22 Tw T* (\035\017\006\036 1. \200)Tj /Span<>> BDC ( )Tj EMC (29)Tj /Span<>> BDC ( )Tj EMC (\(42,6%\) \f\035\031\004\026\016\b \b\017\030\031\030\020\017\004\036\f\022\ \017\005 \007\024)Tj 0 Tc 0 Tw (-)Tj 0.016 Tc 0.123 Tw T* [(\f\021\031\023 )0.5(\002\t\035 )0.5(\024\021\022\030\t\021\t\n, )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 9.803 0 Td (39)Tj /Span<>> BDC ( )Tj EMC 1.403 0 Td (\(57,6%\))Tj /Span<>> BDC ( )Tj EMC 3.667 0 Td [(\227 )0.5(\035\026\023\026\030\024\f\022\024\023\017)]TJ 0 Tc 0 Tw (-)Tj 0.016 Tc 0.194 Tw -14.874 -1.218 Td (\004\036\f\022\017\n. \215\030\017)Tj /Span<>> BDC ( )Tj EMC [(\024\021\022\030\t\021\t\b \024\023\036\030\026\006\017\016\b \027\026\017\ \002\024\035\036\036 \004\026\f\021\024)16( )]TJ 0.374 Tw T* [(\017\f\023\024\035\034\024\r\026\035\f\016 )0.5(\f\030\036\007\017\027\027\t\005 )0.5(\r\036\030\021\017\022\026\035\034\027\t\005 )0.5(\030\026\030\036.)16( )]TJ 0.135 Tw T* (\215\030\017)Tj /Span<>> BDC ( )Tj EMC (\035\026\023\026\030\024\f\022\024\023\017\004\036\f\022\017\b \024\023\036\ \030\026\006\017\016\b \031)Tj /Span<>> BDC ( )Tj EMC [(\002\024\035\034\001\017\027\f\021\r\026)16( )]TJ 0.097 Tw T* (\023\026\006\017\036\027\021\024\r \023\030\017\n\036\027\016\035\f\016 \ \020\017\002\030\017\007\027\t\005 \007\024\f\021\031\023 \f)Tj /Span<>> BDC ( )Tj EMC (\021\030\036\n\016-)Tj 0.128 Tw T* (\023\016\021\034\033 \023\024\030\021\026\n\017 \r)Tj /Span<>> BDC ( )Tj EMC (\f\024\004\036\021\026\027\017\017 \f)Tj /Span<>> BDC ( )Tj EMC [(\n\017\027\017-\035\026\023\026\030\024\021\024\n\027\t\n)16( )]TJ -0.016 Tw T* (\030\026\030\036\024\n.)Tj 0 Tc 0.122 Tw T* (\200 \017\f\f\035\036\007\024\r\026\027\017\036 \002\t\035\017 \r\022\035\ \033\004\036\027\t \021\026\022\017\036 \022\024\035\024\030\036\022\021\ \026\035\034)Tj 0 Tw (-)Tj 0.151 Tw T* (\027\t\036 \024\023\036\030\026\006\017\017, \022\026\022 \023\030\026\r\ \024\f\021\024\030\024\027\027\016\016 \020\036\n\017\022\024\035\220\022\ \021\024\n\017\016 )Tj T* (\(\215\206\), \035\036\r\024\f\021\024\030\024\027\027\016\016 \020\036\n\ \017\022\024\035\220\022\021\024\n\017\016 \(\214\206\), \f\017\020\n\024\ \017\007)Tj /Span<>> BDC (-)Tj EMC 0.165 Tw T* (\220\022\021\024\n\017\016 \(\224\225\) \017)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\036\007\027\016\016 \030\036\036\022\006\017\016 \(\215\217\ \). \224\030\036\007\017 \027\017\b )Tj 0.049 Tw T* (\031)Tj /Span<>> BDC ( )Tj EMC [(31 )0.5(\(45,6%\) )0.5(\002\t\035\026 \r\t\023\024\035\027\036\027\026 )0.5(\215\217, )0.5(\004\021\024 \002\t\035\024 )0.5(\027\026\017\002\024\035\036\036 )]TJ 0.11 Tw T* (\004\026\f\021\024 \r\t\023\024\035\027\016\036\n\024\005 \023\030\024\006\ \036\007\031\030\024\005, \026)Tj /Span<>> BDC ( )Tj EMC (\022\024\021\024\030\024\005 \f\035\036\007\031\036\021 )Tj 0 Tw T* (\215\206, \022\024\021\024\030\026\016 \f\024\f\021\026\r\017\035\026 27\ )Tj /Span<>> BDC ( )Tj EMC (\(39,7%\).)Tj 0.506 Tw T* [(\215\024\f\035\036 )0.5(\030\036\036\022\006\017\017 )0.6(\002\t\035 )0.5(\027\026\035\024\032\036\027 )0.6(\026\027\026\f\021\024\n\024 )0.5(\n\036\032\007\031 )]TJ 0.129 Tw T* (\023\030\024\022\f\017\n\026\035\034\027\t\n \017)Tj /Span<>> BDC ( )Tj EMC (\007\017\f\021\026\035\034\027\t\n \022\024\027\006\026\n\017 \022\017\001\ \022\017. \211)Tj /Span<>> BDC ( )Tj EMC (35 )Tj 0.076 Tw T* (\(51,5%\) \023\026\006\017\036\027\021\024\r \026\027\026\f\021\024\n\024\  \002\t\035 \r\t\023\024\035\027\036\027 \023\024)Tj /Span<>> BDC ( )Tj EMC (\021\017\023\031 )Tj 0.238 Tw T* (\253\022\024\027\036\006-\r-\022\024\027\036\006\273, \031)Tj /Span<>> BDC ( )Tj EMC (33 \(48,5%\))Tj /Span<>> BDC ( )Tj EMC (\227 \023\024)Tj /Span<>> BDC ( )Tj EMC (\021\017\023\031 \253\002\024\022-\r-)Tj 0.179 Tw T* (\002\024\022\273. \230\036\b\027\017\022\026 \026\027\026\f\021\024\n\024\ \026 \002\t\035\026 \017\f\023\024\035\034\024\r\026\027\026 \035\017\002\ \024 )Tj 0.217 Tw T* (\r\030\031\004\027\031\033 \031)Tj /Span<>> BDC ( )Tj EMC (16 \(23,5%\) \023\026\006\017\036\027\021\024\r, \035\017\002\024 \f)Tj /Span<>> BDC ( )Tj EMC (\023\024\n\024\013\034\033 )Tj 0.352 Tw T* (\f\021\036\023\035\036\030\026 \031)Tj /Span<>> BDC ( )Tj EMC (52)Tj /Span<>> BDC ( )Tj EMC (\(76,5%\). \224\030\036\007\017 \035\026\023\026\030\024\f\022\024\023\017\ \004\036\f\022\017\b )Tj 0.31 Tw T* [(\024\023\036\030\026\006\017\005 )0.5(28 )0.6(\(71,8%\) )0.5(\026\027\026\f\021\024\n\024\024\r )0.6(\002\t\035\017 )0.5(\r\t\023\024\035\027\036)]TJ 0 Tw (-)Tj 0.254 Tw T* (\027\t \220\022\f\021\030\026\022\024\030\023\024\030\026\035\034\027\024\ , \026)Tj /Span<>> BDC ( )Tj EMC (11)Tj /Span<>> BDC ( )Tj EMC (\(28,2%\))Tj /Span<>> BDC ( )Tj EMC (\227 \017\027\021\030\026\022\024\030)Tj 0 Tw (-)Tj 0.461 Tw T* [(\023\024\030\026\035\034\027\024. )0.6(\211\001\017\r\026\027\017\036 )0.5(\022\024\032\017 )0.6(\023\030\024\r\024\007\017\035\024\f\034 )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC 19.686 0 Td (\023\024\n\024)Tj 0 Tw (-)Tj 0.114 Tw -19.686 -1.218 Td (\013\034\033 \f\022\024\002 \r)Tj /Span<>> BDC ( )Tj EMC (52)Tj /Span<>> BDC ( )Tj EMC (\(76,5%\) \f\035\031\004\026\016\b \017)Tj /Span<>> BDC ( )Tj EMC (\027\026\035\024\032\036\027\017\036\n \001\r\024\r )Tj -0.039 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (16)Tj /Span<>> BDC ( )Tj EMC (\(23,5%\). \200)Tj /Span<>> BDC ( )Tj EMC (9)Tj /Span<>> BDC ( )Tj EMC (\(13,2%\) \f\035\031\004\026\016\b \002\t\035\026 \f\235\024\030\n\017\030\ \024\r\026\027\026 )Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0 Tw 9 0 0 9 42.5197 730.483 Tm (\020\004\206\f\t\204\004 1.)Tj 0 0 0 1 k /GS1 gs /T1_3 1 Tf ( \212\037\033\037\021\035\016\033\022\024\035\022\021\037 \034\f\016\033\ \037\035\022\036\020\032\002 \036\006\016\001\037\035\016\027\003\024\035\ \036)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf -0.027 Tc 0.027 Tw 0 -1.2 TD [(T)0.5(a)-35.3(b)-40.7(l)-38.7(e)-27( 1)-24.5(.)]TJ 0 0 0 1 k /GS1 gs /T1_3 1 Tf 0 Tc 0 Tw 3.324 0 Td [( D)-12.1(i)6.6(s)-14.8(t)-9.5(r)-39(i)4.6(b)-1.5(u)-4.8(t)-29.1(i)-1.4(o)-4(n o)4.1(f)]TJ /Span<>> BDC ( )Tj EMC [(o)-5.2(p)-11.3(e)-6(r)3.3(a)-9.2(t)-29.1(i)-2.9(v)2.3(e v)6.4(a)-4.2(r)-39(i)1.5(a)-0.9(b)-3.4(le)-22(s a)-5(m)-5.3(o)-4(n)-0.6(g t)-10.6(h)-2.4(e)]TJ /Span<>> BDC ( )Tj EMC [(t)-22.8(w)2.2(o g)-1.5(r)-2(o)-3.4(u)-2.3(p)1.8(s i)4(n t)-10.6(h)-2.4(e)]TJ /Span<>> BDC ( )Tj EMC [(s)-14.8(t)-1.1(u)-5.9(d)-7.2(y)]TJ ET 0 0 0 1 K 0.5 w /GS2 gs q 1 0 0 1 42.5197 715.181 cm 0 0 m 90.959 0 l S Q q 1 0 0 1 42.7697 703.7117 cm 0 0 m 0 11.219 l S Q q 1 0 0 1 133.4783 715.181 cm 0 0 m 124.724 0 l S Q q 1 0 0 1 258.2028 715.181 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 258.2028 703.9617 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 317.7303 715.181 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 377.2579 715.181 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 436.7854 715.181 cm 0 0 m 59.778 0 l S Q q 1 0 0 1 496.313 703.9617 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 42.7697 692.2426 cm 0 0 m 0 11.469 l S Q q 1 0 0 1 257.9528 703.7117 cm 0 0 m 59.778 0 l S Q q 1 0 0 1 258.2028 692.4926 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 317.7303 703.7117 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 377.2579 703.7117 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 377.2579 692.4926 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 436.7854 703.7117 cm 0 0 m 59.778 0 l S Q q 1 0 0 1 496.313 692.4926 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 42.7697 681.0233 cm 0 0 m 0 11.219 l S Q q 1 0 0 1 257.9528 692.2426 cm 0 0 m 59.778 0 l S Q q 1 0 0 1 258.2028 681.0233 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 317.7303 692.2426 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 317.7303 681.0233 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 377.2579 692.2426 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 377.2579 681.0233 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 436.7854 692.2426 cm 0 0 m 59.778 0 l S Q q 1 0 0 1 436.7854 681.0233 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 496.313 681.0233 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 42.5197 680.7733 cm 0 0 m 90.959 0 l S Q q 1 0 0 1 42.7697 669.312 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 133.4783 680.7733 cm 0 0 m 124.724 0 l S Q q 1 0 0 1 133.4783 669.562 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 258.2028 680.7733 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 258.2028 669.562 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 317.7303 680.7733 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 317.7303 669.562 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 377.2579 680.7733 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 377.2579 669.562 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 436.7854 680.7733 cm 0 0 m 59.778 0 l S Q q 1 0 0 1 436.7854 669.562 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 669.562 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.7697 658.1008 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 133.2283 669.312 cm 0 0 m 124.974 0 l S Q q 1 0 0 1 133.4783 658.1008 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 258.2028 669.312 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 258.2028 658.1008 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 317.7303 669.312 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 317.7303 658.1008 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 377.2579 669.312 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 377.2579 658.1008 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 436.7854 669.312 cm 0 0 m 59.778 0 l S Q q 1 0 0 1 436.7854 658.1008 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 658.1008 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 657.8508 cm 0 0 m 90.959 0 l S Q q 1 0 0 1 42.7697 646.3895 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 133.4783 657.8508 cm 0 0 m 124.724 0 l S Q q 1 0 0 1 133.4783 646.6395 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 258.2028 657.8508 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 258.2028 646.6395 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 317.7303 657.8508 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 317.7303 646.6395 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 377.2579 657.8508 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 377.2579 646.6395 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 436.7854 657.8508 cm 0 0 m 59.778 0 l S Q q 1 0 0 1 436.7854 646.6395 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 646.6395 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.7697 634.9282 cm 0 0 m 0 11.461 l S Q q 1 0 0 1 133.2283 646.3895 cm 0 0 m 124.974 0 l S Q q 1 0 0 1 133.4783 635.1782 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 258.2028 646.3895 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 258.2028 635.1782 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 317.7303 646.3895 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 317.7303 635.1782 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 377.2579 646.3895 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 377.2579 635.1782 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 436.7854 646.3895 cm 0 0 m 59.778 0 l S Q q 1 0 0 1 436.7854 635.1782 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 635.1782 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.7697 623.4669 cm 0 0 m 0 11.461 l S Q q 1 0 0 1 133.2283 634.9282 cm 0 0 m 124.974 0 l S Q q 1 0 0 1 133.4783 623.7169 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 258.2028 634.9282 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 258.2028 623.7169 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 317.7303 634.9282 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 317.7303 623.7169 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 377.2579 634.9282 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 377.2579 623.7169 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 436.7854 634.9282 cm 0 0 m 59.778 0 l S Q q 1 0 0 1 436.7854 623.7169 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 623.7169 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.7697 612.2556 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 133.2283 623.4669 cm 0 0 m 124.974 0 l S Q q 1 0 0 1 133.4783 612.2556 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 258.2028 623.4669 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 258.2028 612.2556 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 317.7303 623.4669 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 317.7303 612.2556 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 377.2579 623.4669 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 377.2579 612.2556 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 436.7854 623.4669 cm 0 0 m 59.778 0 l S Q q 1 0 0 1 436.7854 612.2556 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 612.2556 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 612.0056 cm 0 0 m 90.959 0 l S Q q 1 0 0 1 42.7697 600.5443 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 133.4783 612.0056 cm 0 0 m 124.724 0 l S Q q 1 0 0 1 133.4783 600.7943 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 258.2028 612.0056 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 258.2028 600.7943 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 317.7303 612.0056 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 317.7303 600.7943 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 377.2579 612.0056 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 377.2579 600.7943 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 436.7854 612.0056 cm 0 0 m 59.778 0 l S Q q 1 0 0 1 436.7854 600.7943 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 600.7943 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.7697 589.0831 cm 0 0 m 0 11.461 l S Q q 1 0 0 1 133.2283 600.5443 cm 0 0 m 124.974 0 l S Q q 1 0 0 1 133.4783 589.3331 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 258.2028 600.5443 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 258.2028 589.3331 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 317.7303 600.5443 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 317.7303 589.3331 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 377.2579 600.5443 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 377.2579 589.3331 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 436.7854 600.5443 cm 0 0 m 59.778 0 l S Q q 1 0 0 1 436.7854 589.3331 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 589.3331 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.7697 577.6218 cm 0 0 m 0 11.461 l S Q q 1 0 0 1 133.2283 589.0831 cm 0 0 m 124.974 0 l S Q q 1 0 0 1 133.4783 577.8718 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 258.2028 589.0831 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 258.2028 577.8718 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 317.7303 589.0831 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 317.7303 577.8718 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 377.2579 589.0831 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 377.2579 577.8718 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 436.7854 589.0831 cm 0 0 m 59.778 0 l S Q q 1 0 0 1 436.7854 577.8718 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 577.8718 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.7697 566.4105 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 133.2283 577.6218 cm 0 0 m 124.974 0 l S Q q 1 0 0 1 133.4783 566.4105 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 258.2028 577.6218 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 258.2028 566.4105 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 317.7303 577.6218 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 317.7303 566.4105 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 377.2579 577.6218 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 377.2579 566.4105 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 436.7854 577.6218 cm 0 0 m 59.778 0 l S Q q 1 0 0 1 436.7854 566.4105 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 566.4105 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 566.1605 cm 0 0 m 90.959 0 l S Q q 1 0 0 1 42.7697 554.6992 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 133.4783 566.1605 cm 0 0 m 124.724 0 l S Q q 1 0 0 1 133.4783 554.9492 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 258.2028 566.1605 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 258.2028 554.9492 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 317.7303 566.1605 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 317.7303 554.9492 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 377.2579 566.1605 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 377.2579 554.9492 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 436.7854 566.1605 cm 0 0 m 59.778 0 l S Q q 1 0 0 1 436.7854 554.9492 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 554.9492 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.7697 543.4879 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 133.2283 554.6992 cm 0 0 m 124.974 0 l S Q q 1 0 0 1 133.4783 543.4879 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 258.2028 554.6992 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 258.2028 543.4879 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 317.7303 554.6992 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 317.7303 543.4879 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 377.2579 554.6992 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 377.2579 543.4879 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 436.7854 554.6992 cm 0 0 m 59.778 0 l S Q q 1 0 0 1 436.7854 543.4879 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 543.4879 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 543.2379 cm 0 0 m 90.959 0 l S Q q 1 0 0 1 42.7697 531.7766 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 133.4783 543.2379 cm 0 0 m 124.724 0 l S Q q 1 0 0 1 133.4783 532.0266 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 258.2028 543.2379 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 258.2028 532.0266 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 317.7303 543.2379 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 317.7303 532.0266 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 377.2579 543.2379 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 377.2579 532.0266 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 436.7854 543.2379 cm 0 0 m 59.778 0 l S Q q 1 0 0 1 436.7854 532.0266 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 532.0266 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.7697 520.5653 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 133.2283 531.7766 cm 0 0 m 124.974 0 l S Q q 1 0 0 1 133.4783 520.5653 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 258.2028 531.7766 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 258.2028 520.5653 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 317.7303 531.7766 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 317.7303 520.5653 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 377.2579 531.7766 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 377.2579 520.5653 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 436.7854 531.7766 cm 0 0 m 59.778 0 l S Q q 1 0 0 1 436.7854 520.5653 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 520.5653 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 520.3153 cm 0 0 m 90.959 0 l S Q q 1 0 0 1 42.7697 508.8541 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 133.4783 520.3153 cm 0 0 m 124.724 0 l S Q q 1 0 0 1 133.4783 509.1041 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 258.2028 520.3153 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 258.2028 509.1041 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 317.7303 520.3153 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 317.7303 509.1041 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 377.2579 520.3153 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 377.2579 509.1041 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 436.7854 520.3153 cm 0 0 m 59.778 0 l S Q q 1 0 0 1 436.7854 509.1041 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 509.1041 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.7697 497.6428 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 133.2283 508.8541 cm 0 0 m 124.974 0 l S Q q 1 0 0 1 133.4783 497.6428 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 258.2028 508.8541 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 258.2028 497.6428 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 317.7303 508.8541 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 317.7303 497.6428 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 377.2579 508.8541 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 377.2579 497.6428 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 436.7854 508.8541 cm 0 0 m 59.778 0 l S Q q 1 0 0 1 436.7854 497.6428 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 497.6428 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 497.3928 cm 0 0 m 90.959 0 l S Q q 1 0 0 1 42.7697 485.9315 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 133.4783 497.3928 cm 0 0 m 124.724 0 l S Q q 1 0 0 1 133.4783 486.1815 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 258.2028 497.3928 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 258.2028 486.1815 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 317.7303 497.3928 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 317.7303 486.1815 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 377.2579 497.3928 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 377.2579 486.1815 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 436.7854 497.3928 cm 0 0 m 59.778 0 l S Q q 1 0 0 1 436.7854 486.1815 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 486.1815 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.7697 474.7202 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 133.2283 485.9315 cm 0 0 m 124.974 0 l S Q q 1 0 0 1 133.4783 474.7202 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 258.2028 485.9315 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 258.2028 474.7202 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 317.7303 485.9315 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 317.7303 474.7202 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 377.2579 485.9315 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 377.2579 474.7202 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 436.7854 485.9315 cm 0 0 m 59.778 0 l S Q q 1 0 0 1 436.7854 474.7202 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 474.7202 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 474.4702 cm 0 0 m 90.959 0 l S Q q 1 0 0 1 133.4783 474.4702 cm 0 0 m 124.724 0 l S Q q 1 0 0 1 258.2028 474.4702 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 317.7303 474.4702 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 377.2579 474.4702 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 436.7854 474.4702 cm 0 0 m 59.778 0 l S Q BT /GS1 gs /T1_2 1 Tf 8 0 0 8 130.3145 695.0771 Tm (\200\002\220\004\213\004\003\r\f\t )Tj 25.333 1.434 Td (\200\006\t\214\r\b\235\r\214\002\r \210\217\003\006\002\005\217\003\002\ )Tj -6.167 -1.434 Td (\222\f\r\220\003\006\002\220\002\004\n\210\f\235\204\t\235)Tj 16.176 0 Td (\224\033-\217\220\004\f\001\212\r\f\001)Tj /T1_4 1 Tf -15.895 -1.433 Td (n)Tj /T1_2 1 Tf 7.283 -0.001 Td (%)Tj /T1_4 1 Tf 7.598 0.001 Td (n)Tj /T1_2 1 Tf 7.283 -0.001 Td (%)Tj /T1_0 1 Tf -52.202 -1.433 Td (\210\023\036\030\026\021\017\r\027\t\005 \007\024\f\021\031\023)Tj 16.765 0 Td (\210\021\022\030\t\021\t\005)Tj 13.03 0 Td (11)Tj 6.719 0 Td (35,5%)Tj 8.163 0 Td (18)Tj 6.719 0 Td (48,6%)Tj -36.767 -1.433 Td (\214\026\023\026\030\024\f\022\024\023\017\004\036\f\022\017\005)Tj 15.166 0 Td (20)Tj 6.719 0 Td (64,5%)Tj 8.163 0 Td (19)Tj 6.719 0 Td (51,4%)Tj -51.396 -1.433 Td (\217\026\030\036\t / \023\024\030\021\t)Tj 13.026 0 Td (4 \023\024\030\021\026)Tj /Span<>> BDC ( )Tj EMC (+)Tj /Span<>> BDC ( )Tj EMC (\n\017\027\017\035\026\023\026\030\024\021\024\n\017\016)Tj 17.02 0 Td (1)Tj 6.719 0 Td (3,2%)Tj 8.163 0 Td (1)Tj 6.719 0 Td (2,7%)Tj -34.662 -1.433 Td (5 \023\024\030\021\024\r)Tj 13.061 0 Td (6)Tj 6.469 0 Td (19,4%)Tj 8.413 0 Td (2)Tj 6.719 0 Td (5,4%)Tj -38.876 -1.433 Td (5 \023\024\030\021\024\r)Tj /Span<>> BDC ( )Tj EMC (+)Tj /Span<>> BDC ( )Tj EMC (\n\017\027\017\035\026\023\026\030\024\021\024\n\017\016)Tj 17.025 0 Td (13)Tj 6.719 0 Td (41,9%)Tj 8.163 0 Td (16)Tj 6.719 0 Td (43,2%)Tj -37.609 -1.433 Td (\224\030\036\007\017\027\027\026\016 \035\026\023\026\030\024\021\024\n\017\ \016)Tj 16.008 0 Td (11)Tj 6.719 0 Td (35,5%)Tj 8.163 0 Td (18)Tj 6.719 0 Td (48,6%)Tj -51.396 -1.433 Td (\210\023\036\030\026\006\017\016)Tj 14.759 0 Td (\215\036\030\036\007\027\016\016 \030\036\036\022\006\017\016)Tj 15.037 0 Td (17)Tj 6.719 0 Td (54,8%)Tj 8.163 0 Td (14)Tj 6.719 0 Td (37,8%)Tj -39.5 -1.433 Td (\215\030\026\r\024\f\021\024\030\024\027\027\016\016 \020\036\n\017\022\024\ \035\220\022\021\024\n\017\016)Tj 17.899 0 Td (12)Tj 6.719 0 Td (38,7%)Tj 8.163 0 Td (17)Tj 6.719 0 Td (45,9%)Tj -36.009 -1.433 Td (\224\017\020\n\024\017\007\220\022\021\024\n\017\016)Tj 14.658 0 Td (2)Tj 6.719 0 Td (6,5%)Tj 8.163 0 Td (3)Tj 6.719 0 Td (8,1%)Tj -39.492 -1.433 Td (\214\036\r\024\f\021\024\030\024\027\027\016\016 \020\036\n\017\022\024\035\ \220\022\021\024\n\017\016)Tj 17.891 0 Td (0)Tj 6.719 0 Td (0,0%)Tj 8.163 0 Td (3)Tj 6.719 0 Td (8,1%)Tj -51.646 -1.433 Td (\230\017\023 \026\027\026\f\021\024\n\024\026)Tj 15.695 0 Td (\025\024\027\036\006-\r-\022\024\027\036\006)Tj 14.101 0 Td (18)Tj 6.719 0 Td (58,1%)Tj 8.163 0 Td (17)Tj 6.719 0 Td (45,9%)Tj -34.697 -1.433 Td (\207\024\022-\r-\002\024\022)Tj 13.096 0 Td (13)Tj 6.719 0 Td (41,9%)Tj 8.163 0 Td (20)Tj 6.719 0 Td (54,1%)Tj -51.396 -1.433 Td (\224\023\024\f\024\002 \235\024\030\n\017\030\024\r\026\027\017\016 )Tj 0 -1.2 TD (\026\027\026\f\021\024\n\024\026)Tj 17.302 1.2 Td (\217\031\004\027\024\005)Tj 12.743 0 Td (7)Tj 6.469 0 Td (22,6%)Tj 8.413 0 Td (9)Tj 6.469 0 Td (24,3%)Tj -36.86 -1.433 Td (\224\001\017\r\026\033\013\017\005 \026\023\023\026\030\026\021)Tj 15.259 0 Td (24)Tj 6.719 0 Td (77,4%)Tj 8.163 0 Td (28)Tj 6.719 0 Td (75,7%)Tj -51.396 -1.433 Td (\211\001\017\r\026\027\017\036 \022\024\032\017)Tj 17.15 0 Td (\224\021\036\023\035\036\030)Tj 12.645 0 Td (27)Tj 6.719 0 Td (87,1%)Tj 8.163 0 Td (25)Tj 6.719 0 Td (67,6%)Tj -34.069 -1.433 Td (\217\031\004\027\024\036)Tj 12.718 0 Td (4)Tj 6.469 0 Td (12,9%)Tj 8.163 0 Td (12)Tj 6.719 0 Td (32,4%)Tj -51.396 -1.433 Td (\224\021\024\n)Tj 18.25 0 Td (\212\026)Tj 11.795 0 Td (3)Tj 6.719 0 Td (9,7%)Tj 8.163 0 Td (6)Tj 6.469 0 Td (16,2%)Tj -33.346 -1.433 Td (\203\036\021)Tj 11.745 0 Td (28)Tj 6.719 0 Td (90,3%)Tj 8.163 0 Td (31)Tj 6.719 0 Td (83,8%)Tj 1 0.68 0 0.12 k /GS0 gs /T1_5 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\034\201\025\b\222\016\017)-9.9(\026\021\r\215\025\016 \025\211\215\025\212\016\215\026\201\025\r\025\016\ \215\001\235\t\205\211\001\026)11(\016\t\214\215\025\016 \021\b\b)-10(\t\016\211\025\r\001\215\021\016 )]TJ 0 -1 TD [(\242\215\016\201\202)10(\016\026\021\f\016\b\017\021 \200\b)-10(\026\201\025\207\b)-10(\026\r \r\022\017)10(\025\t\025\201\016\017)-10(\026)11(\001\t\214\215\025\207 \021\201\200\201\202\021\021)]TJ 41.119 1 Td [(A Pr)20(ospectiv)12(e Single Centr)31(e Obser)-20.9(v)10(ational Study )]TJ 3.383 -1 Td [(on\022Ener)31.1(gy\022De)11(vices in Color)31(ectal Sur)31(ger)-31(y)]TJ -44.502 96.622 Td [(\036\033\030\031\030\217\n)-20.9(\035\210\217\241\003 \013\032)50(\n)42(\032\210\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj /T1_6 1 Tf 25 0 0 25 504.6022 56.0378 Tm (115)Tj ET endstream endobj 1620 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.168 Tw 10 0 0 10 70.8661 724.8299 Tm (\031\007\036\035\016\016 \024\f\024\002\024\036 \r\027\017\n\026\027\017\ \036 \030\026\035\017\004\027\t\n \017\027\021\030\026\024\023\036\030\026\ \006\017)Tj 0 Tw (-)Tj 0.33 Tw 0 -1.218 TD (\024\027\027\t\n \017)Tj /Span<>> BDC ( )Tj EMC (\023\024\f\035\036\024\023\036\030\026\006\017\024\027\027\t\n \023\026\030\ \026\n\036\021\030\026\n. \236\031\004\026\016 )Tj 0.348 Tw T* [(\021\026\022\017\036 \235\026\022\021\024\030\t, \022\026\022 \023\030\024\ \007\024\035\032\017\021\036\035\034\027\024\f\021\034 )0.6(\024\023\036\030\026\006\017\017, )]TJ 0.035 Tw T* (\022\030\024\r\024\023\024\021\036\030\016, \004\026\f\021\024\021\026 \024\ \f\035\024\032\027\036\027\017\005 \017)Tj /Span<>> BDC ( )Tj EMC (\024\002\013\017\036 \030\036\031\035\034\021\026)Tj 0 Tw (-)Tj 0.072 Tw T* (\021\t \035\036\004\036\027\017\016 \023\026\006\017\036\027\021\024\r, \ \017\f\f\035\036\007\024\r\026\027\017\036 \f\021\030\036\n\017\021\f\016\ \007\026\021\034 )Tj 0.111 Tw T* (\r\f\036\f\021\024\030\024\027\027\033\033 \024\006\036\027\022\031 \023\ \030\017\n\036\027\036\027\017\016 \220\021\017\b \220\027\036\030\020\036\ \021\017\004\036)Tj 0 Tw (-)Tj 0.098 Tw 0 -1.218 TD (\f\022\017\b \031\f\021\030\024\005\f\021\r \r)Tj /Span<>> BDC ( )Tj EMC (\022\035\017\027\017\004\036\f\022\024\005 \023\030\026\022\021\017\022\036\ . \224)Tj /Span<>> BDC ( )Tj EMC (\023\024\n\024\013\034\033 )Tj 0.088 Tw 0 -1.218 TD (\220\021\024\020\024 \026\027\026\035\017\026 \017\f\f\035\036\007\024\r\ \026\027\017\036 \027\026\n\036\030\036\027\024 \023\030\036\007\024\f\021\ \026\r\017\021\034 )Tj 0.176 Tw T* (\006\036\027\027\031\033 \017\027\235\024\030\n\026\006\017\033 \024)Tj /Span<>> BDC ( )Tj EMC (\023\030\036\017\n\031\013\036\f\021\r\026\b \017)Tj /Span<>> BDC ( )Tj EMC (\024\020\030\026\027\017\004\036)Tj 0 Tw (-)Tj 0.31 Tw T* (\027\017\016\b \022\026\032\007\024\020\024 \031\f\021\030\024\005\f\021\ \r\026, \021\036\n \f\026\n\t\n \017\027\235\024\030\n\017\030\031\016 )Tj 0.097 Tw T* (\024)Tj /Span<>> BDC ( )Tj EMC (\023\030\017\027\016\021\017\017 \b\017\030\031\030\020\017\004\036\f\022\ \017\b \030\036\001\036\027\017\005 \017)Tj /Span<>> BDC ( )Tj EMC (\023\024\021\036\027\006\017\026\035\034\027\024 )Tj -0.016 Tw T* (\027\026\023\030\026\r\035\016\016 \030\026\030\026\002\024\021\022\031\ \023\036\030\036\007\024\r\t\b \n\036\021\024\007\024\r \r)Tj /Span<>> BDC ( )Tj EMC (\022\024\035\024\030\036\022)Tj 0 Tw (-)Tj 0 -1.218 TD (\021\026\035\034\027\024\005 \b\017\030\031\030\020\017\017.)Tj 0.082 Tw 0 -1.218 TD (\200 \023\024\f\035\036\007\027\036\036 \r\030\036\n\016 \002\t\035\024 \ \023\030\024\r\036\007\036\027\024 \n\027\024\032\036\f\021\r\024 \023\030\ \024)Tj 0 Tw (-)Tj 0.299 Tw 0 -1.218 TD (\f\023\036\022\021\017\r\027\t\b \017\f\f\035\036\007\024\r\026\027\017\005\ \007\035\016 \024\006\036\027\022\017 \030\036\031\035\034\021\026\021\ \024\r )Tj 0.147 Tw T* (\024\023\036\030\026\006\017\005 \f)Tj /Span<>> BDC ( )Tj EMC (\017\f\023\024\035\034\024\r\026\027\017\036\n \030\026\035\017\004\027\ \t\b \220\027\036\030\020\036\021\017\004\036)Tj 0 Tw (-)Tj 0.024 Tw T* (\f\022\017\b \031\f\021\030\024\005\f\021\r. \025\030\026\021\022\024\f\030\ \024\004\027\t\036 \030\036\031\035\034\021\026\021\t \023\030\017\n\036\ \027\036)Tj 0 Tw (-)Tj 0.235 Tw T* [(\027\017\016 \030\026\007\017\024\004\026\f\021\024\021\027\024\020\024 \ )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC [(\031\035\034\021\030\026\r\031\022\024\r\024\020\024 )0.5(\f\022\026\035\034\023\036\035\016, )]TJ 0.303 Tw T* (\024\022\026\026\035\017\f\034 \035\031\004\001\036, \004\036\n \023\030\ \017)Tj /Span<>> BDC ( )Tj EMC (\021\030\026\007\017\006\017\024\027\027\024\005 \220\035\036\022\021\030\ \024)Tj 0 Tw (-)Tj 0.291 Tw T* (\b\017\030\031\030\020\017\017. \203\036\022\024\021\024\030\t\036 \026\r\ \021\024\030\t \024\002\027\026\030\031\032\017\035\017, \004\021\024 \017\ \f)Tj 0 Tw (-)Tj 0.316 Tw T* (\023\024\035\034\024\r\026\027\017\036 \030\026\007\017\024\004\026\f\021\ \024\021\027\024\020\024 \f\022\026\035\034\023\036\035\016 \r\024 \r\030\ \036\n\016 )Tj 0.281 Tw T* (\035\026\023\026\030\024\f\022\024\023\017\004\036\f\022\024\005 \022\024\ \035\024\030\036\022\021\026\035\034\027\024\005 \030\036\036\022\006\017\ \017 \023\030\017)Tj 0 Tw (-)Tj 0.062 Tw T* (\r\024\007\017\021 \022)Tj /Span<>> BDC ( )Tj EMC (\f\024\022\030\026\013\036\027\017\033 \r\030\036\n\036\027\017 \024\023\ \036\030\026\006\017\017 \017)Tj /Span<>> BDC ( )Tj EMC (\f\027\017\032\036\027\017\033 )Tj -0.043 Tw T* (\022\030\024\r\024\023\024\021\036\030\017 \023\024)Tj /Span<>> BDC ( )Tj EMC (\f\030\026\r\027\036\027\017\033 \f)Tj /Span<>> BDC ( )Tj EMC (\017\f\023\024\035\034\024\r\026\027\017\036\n \031\035\034\021\030\026\ )Tj 0 Tw (-)Tj 0.194 Tw T* (\r\031\022\024\r\t\b \022\024\026\020\031\035\017\030\031\033\013\017\b\ \027\024\032\027\017\006 \(UCS\). \200)Tj /Span<>> BDC ( )Tj EMC (\024\021\035\017\004\017\036 )Tj 0.256 Tw T* (\024\021 \220\021\024\020\024, \027\036\007\026\r\027\036\036 \017\f\f\035\ \036\007\024\r\026\027\017\036 \023\024\022\026\026\035\024, \004\021\024\ \r\024 )Tj 0.094 Tw T* (\r\030\036\n\016 \035\026\023\026\030\024\f\022\024\023\017\004\036\f\022\ \024\005 \022\024\035\024\030\036\022\021\026\035\034\027\024\005 \b\017\ \030\031\030\020\017\017 )Tj 0.236 Tw T* [(\027\036 )0.5(\027\026\002\035\033\007\026\035\024\f\034 )0.6(\f\031\013\036\f\021\r\036\027\027\t\b )0.6(\030\026\035\017\004\017\005 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 18.991 0 Td (\022\030\026\021\022\024)Tj 0 Tw (-)Tj 0.219 Tw -18.991 -1.218 Td (\f\030\024\004\027\t\b \030\036\031\035\034\021\026\021\026\b \n\036\032\ \007\031 UCS \017)Tj /Span<>> BDC ( )Tj EMC (\030\026\007\017\024\004\026\f\021\024\021\027\t\n )Tj 0.04 Tw T* (\f\022\026\035\034\023\036\035\036\n. \200)Tj /Span<>> BDC ( )Tj EMC (\022\024\027\036\004\027\024\n \f\004\201\021\036, \r\t\002\024\030 \017\ \f\023\024\035\034\031\036\n\024\020\024 )Tj 0.158 Tw T* [(\031\f\021\030\024\005\f\021\r\026 \007\024\035\032\036\027 \024\f\027\024\ \r\t\r\026\021\034\f\016 )0.5(\027\026)]TJ /Span<>> BDC ( )Tj EMC (\023\030\036\007\023\024\004\021\036\027\017\016\b )Tj 0 Tw T* (\b\017\030\031\030\020\026)Tj /Span<>> BDC ( )Tj EMC ([1].)Tj 0.079 Tw T* (\200 \017\f\f\035\036\007\024\r\026\027\017\017, \023\030\024\r\036\007\201\ \027\027\024\n \025\026\n\023\026\027\034\016\004\004\017 \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. )Tj 0.027 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (2007 \020\024\007\031 \(\236\021\026\035\017\016\), \f\030\026\r\027\017\ \r\026\035\017\f\034 \220\035\036\022\021\030\024\021\036\030\n\017\004\036\ )Tj 0 Tw (-)Tj 0.031 Tw T* (\f\022\026\016 \002\017\023\024\035\016\030\027\026\016 \020\036\030\n\036\ \021\017\026\006\017\016 \f\024\f\031\007\024\r \(\225\207\200\224\) \017\ )Tj /Span<>> BDC ( )Tj EMC (UCS )Tj 0.234 Tw T* (\023\030\017)Tj /Span<>> BDC ( )Tj EMC (\035\026\023\026\030\024\f\022\024\023\017\004\036\f\022\017\b \022\024\035\ \220\022\021\024\n\017\016\b. \207\t\035\017 \r\t\023\024\035)Tj 0 Tw (-)Tj 0.197 Tw T* (\027\036\027\t \023\030\026\r\024\f\021\024\030\024\027\027\016\016 \020\ \036\n\017\022\024\035\220\022\021\024\n\017\016, \035\036\r\024\f\021\024\ \030\024\027)Tj 0 Tw (-)Tj 0.282 Tw T* [(\027\016\016 )0.5(\020\036\n\017\022\024\035\220\022\021\024\n\017\016 )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC 10.224 0 Td [(\027\017\022\026\016 \023\036\030\036\007\027\016\016 )0.6(\030\036\036\022\006\017\016. )]TJ -0.011 Tw -10.224 -1.218 Td [(\224\021\026\021\017\f\021\017\004\036\f\022\017 )0.6(\027\026\004\017\n\t\b )0.6(\030\026\035\017\004\017\005 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 15.167 0 Td [(\f\030\036\007\027\036\005 )0.5(\023\030\024\007\024\035)]TJ 0 Tw (-)Tj 0.187 Tw -15.167 -1.218 Td [(\032\017\021\036\035\034\027\024\f\021\017 )0.5(\024\023\036\030\026\006\017\017 \017\035\017 \f\030\036\007\027\036\005\ \023\030\024\007\024\035\032\017\021\036\035\034)]TJ 0 Tw (-)Tj -0.005 Tw T* [(\027\024\f\021\017 \023\024\f\035\036\024\023\036\030\026\006\017\024\027\ \027\024\020\024 )0.5(\023\030\036\002\t\r\026\027\017\016 \n\036\032\007\031 \007\r\031\n\016\ )]TJ 0.035 Tw T* [(\020\030\031\023\023\026\n\017 )0.5(\027\036 )0.6(\027\026\002\035\033\007\026\035\024\f\034. )0.6(\210\007\027\026\022\024 )0.5(\027\026\002\035\033\007\026\035\017\f\034 )0.6(\030\026)]TJ 0 Tw (-)Tj 0.146 Tw T* (\035\017\004\017\016 \r)Tj /Span<>> BDC ( )Tj EMC (\f\030\036\007\027\036\005 \022\030\024\r\024\023\024\021\036\030\036 \023\ \024\f\035\036 \022\026\032\007\024\005 \024\023\036\030\026)Tj 0 Tw (-)Tj T* (\006\017\017 \r)Tj /Span<>> BDC ( )Tj EMC (\007\r\031\b \020\030\031\023\023\026\b [1,2].)Tj -0.067 Tw T* (\200 \017\f\f\035\036\007\024\r\026\027\017\017, \023\030\024\r\036\007\201\ \027\027\024\n \230\026\022\026\007\024\005 \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. \r)Tj /Span<>> BDC ( )Tj EMC (2005 )Tj -0.073 Tw T* (\020\024\007\031 \(\233\023\024\027\017\016\), \002\t\035\024 \r\022\035\ \033\004\036\027\024 30 \023\026\006\017\036\027\021\024\r, \023\036\030\ \036\027\201\f)Tj 0 Tw (-)Tj 0.133 Tw T* [(\001\017\b )0.5(\030\036\036\022\006\017\033 \023\024\023\036\030\036\004\027\024\005 )0.5(\024\002\024\007\024\004\027\024\005 \022\017\001\022\017 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC (\f\017\020)Tj 0 Tw (-)Tj 0.366 Tw T* [(\n\024\017\007\220\022\021\024\n\017\033 )0.5(\035\026\023\026\030\024\f\022\024\023\017\004\036\f\022\017\n \n\036\021\ \024\007\024\n \023\024)]TJ /Span<>> BDC ( )Tj EMC (\023\024)Tj 0 Tw (-)Tj 0.242 Tw T* [(\r\024\007\031 \035\024\022\026\004\036\f\021\r\036\027\027\t\b )0.5(\027\024\r\024\024\002\030\026\024\r\026\027\017\005. )0.5(\200\024)]TJ /Span<>> BDC ( )Tj EMC (\r\030\036\n\016 )Tj 0.693 Tw T* [(\024\023\036\030\026\006\017\017 )0.5(\017\f\023\024\035\034\024\r\026\035\017\f\034 )0.6(\035\017\002\024 )0.6(\030\026\007\017\024\004\026\f\021\024\021\027\t\005 )]TJ 0.369 Tw T* [(\f\022\026\035\034\023\036\035\034 \(EB)10(V)27(S\), \035\017\002\024 \031\035\034\021\030\026\r\031\022\024\r\024\005 \ \f\022\026\035\034\023\036\035\034 )]TJ 0.015 Tw T* [(\(UCS\). )0.5(\225\021\017 )0.5(\031\f\021\030\024\005\f\021\r\026 )0.5(\017\f\023\024\035\034\024\r\026\035\017\f\034 )0.6(\007\035\016 )0.5(\007\017\f\f\036\022\006\017\017 )]TJ 0.135 Tw T* (\002\030\t\032\036\005\022\017 \024\002\024\007\024\004\027\024\005 \022\ \017\001\022\017. \215\024\f\035\036 \024\002\024\017\b \b\017\030\031\030\ \020\017)Tj 0 Tw (-)Tj 0.134 Tw T* [(\004\036\f\022\017\b \r\n\036\001\026\021\036\035\034\f\021\r )0.5(\023\024\r\021\024\030\027\024\036 \022\030\024\r\024\021\036\004\036\027\ \017\036 )0.5(\002\t\035\024 )]TJ 0.086 Tw 23.244 64.543 Td (\027\026\004\017\021\036\035\034\027\024 \f\027\017\032\036\027\024 \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036, \r)Tj /Span<>> BDC ( )Tj EMC (\022\024\021\024\030\024\005 \017\f\023\024\035\034\024)Tj 0 Tw (-)Tj 0.141 Tw T* [(\r\026\035\f\016 EB)10(V)27(S, \023\024)]TJ /Span<>> BDC ( )Tj EMC (\f\030\026\r\027\036\027\017\033 \f)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\024\005, \r)Tj /Span<>> BDC ( )Tj EMC (\022\024\021\024\030\024\005 \017\f)Tj 0 Tw (-)Tj 0.068 Tw T* (\023\024\035\034\024\r\026\035\f\016 UCS. \215\030\017)Tj /Span<>> BDC ( )Tj EMC [(\017\f\023\024\035\034\024\r\026\027\017\017 EB)10(V)27(S \r\024 \r\030\036\n\016 )]TJ 0.06 Tw T* [(\035\033\002\024\005 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC [(\024\023\036\030\026\006\017\005 \r\030\036\n\016, )0.5(\027\036\024\002\b\024\007\017\n\024\036 )0.5(\007\035\016 \007\017\f\f\036\022)]TJ 0 Tw (-)Tj 0.05 Tw T* (\006\017\017 \002\030\t\032\036\005\022\017 \024\002\024\007\024\004\027\ \024\005 \022\017\001\022\017, \021\026\022\032\036 \027\026\004\017\021\ \036\035\034\027\024 )Tj 0 Tw T* (\f\024\022\030\026\013\026\035\024\f\034 [2,3].)Tj 0.113 Tw 0 -1.218 TD [(\225\021\017 \030\036\031\035\034\021\026\021\t \002\t\035\017 )0.5(\f\r\016\026\027\t \f\024 \f\021\026\021\017\f\021\017\004\036\f\022\017\ )0.6(\027\026)]TJ 0 Tw (-)Tj 0.101 Tw 0 -1.218 TD (\004\017\n\t\n \f\027\017\032\036\027\017\036\n \022\030\024\r\024\023\024\ \021\036\030\017 \r\024 \r\030\036\n\016 \024\023\036\030\026\006\017\017\ . )Tj 0.028 Tw T* (\200)Tj /Span<>> BDC ( )Tj EMC 0.806 0 Td [(\020\030\031\023\023\036, )0.5(\023\030\017\n\036\027\016\r\001\036\005 )0.6(\021\030\026\007\017\006\017\024\027\027\t\005 )0.6(\n\036\021\024\007, )0.5(\027\026\002\035\033)]TJ 0 Tw (-)Tj 0.247 Tw -0.806 -1.218 Td (\007\026\035\f\016 \002\024\035\036\036 \r\t\f\024\022\017\005 \031\030\024\ \r\036\027\034 \023\036\030\036\b\024\007\026 \027\026)Tj /Span<>> BDC ( )Tj EMC (\007\030\031\020\017\036 )Tj 0.14 Tw T* (\n\036\021\024\007\t. \203\036 \002\t\035\024 \r\t\016\r\035\036\027\024\ \f\031\013\036\f\021\r\036\027\027\t\b \030\026\035\017\004\017\005 )Tj 0.168 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\027\036\023\024\f\030\036\007\f\021\r\036\027\027\t\b \030\036\031\035\ \034\021\026\021\026\b, \021\026\022\017\b \022\026\022 \026\002\024\035\ \036)Tj 0 Tw (-)Tj 0.015 Tw 0 -1.218 TD (\r\026\036\n\024\f\021\034, \f\n\036\030\021\027\024\f\021\034 \017)Tj /Span<>> BDC ( )Tj EMC [(\023\030\024\007\024\035\032\017\021\036\035\034\027\024\f\021\034 )0.5(\023\030\036\002\t\r\026)]TJ 0 Tw (-)Tj -0.037 Tw 0 -1.218 TD (\027\017\016 \r)Tj /Span<>> BDC ( )Tj EMC (\f\021\026\006\017\024\027\026\030\036. \202\027\026\035\017 \026\021\030\ \026\021 \002\t\035 \f\b\024\032\017\n \007\035\016 \021\030\036\b )Tj 0 Tw 0 -1.218 TD (\020\030\031\023\023 [2,4].)Tj 0.052 Tw T* (\215\024\007\r\024\007\016 \017\021\024\020, \n\024\032\027\024 \f\022\026\ \026\021\034, \004\021\024 \007\026\027\027\024\036 \017\f\f\035\036\007\ \024\r\026)Tj 0 Tw (-)Tj T* (\027\017\036 \027\026\023\030\026\r\035\036\027\024 \027\026)Tj /Span<>> BDC ( )Tj EMC (\030\026\f\001\017\030\036\027\017\036 \002\026\t \027\026\027\017\005\ .)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 303.3769 493.4478 Tm (\017\034\r\237)Tj 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0 Tc 0.021 Tw 10 0 0 10 303.3071 469.0918 Tm (\243)Tj /Span<>> BDC [( )-246( )]TJ EMC 1 0 Td [(\210\006\036\027\017\021\034 \030\036\031\035\034\021\026\021\t \023\030\ \017\n\036\027\036\027\017\016 )0.5(\030\026\035\017\004\027\t\b \017\f\021\024\004)]TJ 0 Tw (-)Tj 0.237 Tw T* (\027\017\022\024\r \220\027\036\030\020\017\017, \021\026\022\017\b \022\ \026\022 \031\035\034\021\030\026\r\031\022\024\r\024\005 \f\022\026\035\ \034)Tj 0 Tw (-)Tj 0.366 Tw T* (\023\036\035\034 \017)Tj /Span<>> BDC ( )Tj EMC (\220\035\036\022\021\030\024\022\024\026\020\031\035\016\006\017\016, \023\ \030\017)Tj /Span<>> BDC ( )Tj EMC (\022\024\035\024\030\036\022\021\026\035\034\027\t\b )Tj 0 Tw T* (\024\023\036\030\026\006\017\016\b.)Tj 0.166 Tw -1 -1.218 Td (\243)Tj /Span<>> BDC [( )-101( )]TJ EMC 1 0 Td [(\210\006\036\027\017\021\034 )0.6(\023\030\024\007\024\035\032\017\021\036\035\034\027\024\f\021\034 )0.6(\024\023\036\030\026\006\017\017, )0.5(\017\027\021\030\026\024\023\036)]TJ 0 Tw (-)Tj 0.141 Tw T* [(\030\026\006\017\024\027\027\031\033 )0.5(\022\030\024\r\024\023\024\021\036\030\033, \024\021\007\036\035\016\036\ \n\024\036 \023\024)]TJ /Span<>> BDC ( )Tj EMC 17.569 0 Td (\007\030\036\027\026\032\031 )Tj 0 Tw -17.569 -1.218 Td (\017)Tj /Span<>> BDC ( )Tj EMC (\022\024\005\022\024-\007\036\027\034.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0.01 Tc 0.018 Tw 14 0 0 14 303.3769 359.4898 Tm [(\f\026\017\031\034\022\024\232)5( \031)5(\016)-18.3(\240\034)-31(\024)35(\037\226\232)]TJ 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0 Tc 0.186 Tw 10 0 0 10 303.3071 335.1338 Tm [(\200 \027\026\f\021\024\016\013\036\036 \023\030\024\f\023\036\022\021\017\ \r\027\024\036 )0.5(\024\007\027\024\006\036\027\021\030\024\r\024\036 \027\026\002\035\033)]TJ 0 Tw (-)Tj 0.208 Tw T* (\007\026\021\036\035\034\027\024\036 \017\f\f\035\036\007\024\r\026\027\017\ \036, \023\030\024\r\036\007\036\027\027\024\036 \r)Tj /Span<>> BDC ( )Tj EMC (\024\021\007\036\035\036\027\017\017 )Tj 0.128 Tw T* (\024\002\013\036\005 \b\017\030\031\030\020\017\017 \(\f 19.12.2022 \023\ \024)Tj /Span<>> BDC ( )Tj EMC (30.09.2024\) \002\t\035\024 )Tj 0.008 Tw T* (\r\022\035\033\004\036\027\024 68 \023\026\006\017\036\027\021\024\r. \212\ \035\016 \031\004\026\f\021\017\016 \r)Tj /Span<>> BDC ( )Tj EMC (\017\f\f\035\036\007\024\r\026\027\017\017 )Tj 0.049 Tw T* (\002\t\035\024 \026\023\030\024\001\036\027\024 \024\007\024\002\030\036\ \027\017\036 \n\036\f\021\027\024\020\024 \220\021\017\004\036\f\022\024\ \020\024 \022\024)Tj 0 Tw (-)Tj 0.206 Tw T* (\n\017\021\036\021\026, \017)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\t \002\t\035\017 \024\021\024\002\030\026\027\ \t \r)Tj /Span<>> BDC ( )Tj EMC (\f\024\024\021\r\036\021\f\021\r\017\017 )Tj 0.155 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\022\030\017\021\036\030\017\016\n\017 \r\022\035\033\004\036\027\017\016\ \017)Tj /Span<>> BDC ( )Tj EMC (\017\f\022\035\033\004\036\027\017\016. \215\026\006\017\036\027\021\026\ \n )Tj 0.135 Tw T* [(\002\t\035 \023\030\036\007\024\f\021\026\r\035\036\027 \017\027\235\024\ \030\n\026\006\017\024\027\027\t\005 )0.5(\035\017\f\021 \031\004\026\f\021\027\017\022\026 )]TJ 0.086 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\023\024\035\031\004\036\027\024 \017\027\235\024\030\n\017\030\024\r\026\ \027\027\024\036 \f\024\020\035\026\f\017\036. \212\026\027\027\t\036 \f\ \024)Tj 0 Tw (-)Tj T* (\002\017\030\026\035\017\f\034 \f)Tj /Span<>> BDC ( )Tj EMC (\017\f\023\024\035\034\024\r\026\027\017\036\n \023\030\024\235\024\030\ \n\t.)Tj 0.298 Tw T* (\200 \017\f\f\035\036\007\024\r\026\027\017\036 \002\t\035\017 \r\022\035\ \033\004\036\027\t \023\026\006\017\036\027\021\t \f\021\026\030\001\036\ )Tj -0.016 Tw T* (18)Tj /Span<>> BDC ( )Tj EMC (\035\036\021, \023\036\030\036\027\036\f\001\017\036 \023\035\026\027\024\ \r\t\036 \022\024\035\024\030\036\022\021\026\035\034\027\t\036 \024\023\ \036\030\026)Tj 0 Tw (-)Tj 0.058 Tw T* (\006\017\017 \023\024)Tj /Span<>> BDC ( )Tj EMC (\023\024\r\024\007\031 \030\026\035\017\004\027\t\b \007\024\002\030\024\ \022\026\004\036\f\021\r\036\027\027\t\b \017)Tj /Span<>> BDC ( )Tj EMC (\035\024)Tj 0 Tw (-)Tj 0.233 Tw T* (\022\026\004\036\f\021\r\036\027\027\t\b \026\002\024\035\036\r\026\027\ \017\005. \210\023\036\030\026\006\017\017 \023\030\024\r\024\007\017\035\ \017\f\034 )Tj 0.232 Tw T* [(\022\026\022 )0.5(\024\021\022\030\t\021\t\n, )0.6(\021\026\022 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 9.276 0 Td [(\035\026\023\026\030\024\f\022\024\023\017\004\036\f\022\017\n )0.6(\007\024\f\021\031\023\024\n. )]TJ 0 Tw -9.276 -1.218 Td (\217\036\031\035\034\021\026\021\t \024\006\036\027\017\r\026\035\017\f\ \034 \023\024)Tj /Span<>> BDC ( )Tj EMC (\f\035\036\007\031\033\013\017\n \023\026\030\026\n\036\021\030\026\n:)Tj 0.002 Tw T* (\243)Tj /Span<>> BDC [( )-265( )]TJ EMC 1 0 Td (\200\030\036\n\016 \024\023\036\030\026\006\017\017 \r)Tj /Span<>> BDC ( )Tj EMC (\n\017\027\031\021\026\b \(\r\030\036\n\016 \024\021 \030\026\030\036\026\ \022\024\032\017 )Tj 0 Tw T* (\007\024)Tj /Span<>> BDC ( )Tj EMC (\031\001\017\r\026\027\017\016 \030\026\027\t\).)Tj 0.314 Tw -1 -1.218 Td (\243)Tj /Span<>> BDC [( )47( )]TJ EMC 1 0 Td (\236\027\021\030\026\024\023\036\030\026\006\017\024\027\027\026\016 \022\ \030\024\r\024\023\024\021\036\030\016 \r)Tj /Span<>> BDC ( )Tj EMC (\n\017\035\035\017\035\017\021\030\026\b )Tj 0 Tw T* (\(\n\026\030\035\036\r\t\036 \f\026\035\235\036\021\022\017)Tj /Span<>> BDC ( )Tj EMC (+)Tj /Span<>> BDC ( )Tj EMC (\024\002\255\201\n \026\f\023\017\030\026\021\024\030\026\).)Tj 0.388 Tw -1 -1.218 Td (\243)Tj /Span<>> BDC [( )121( )]TJ EMC 1 0 Td (\210\002\255\201\n \023\024\f\035\036\024\023\036\030\026\006\017\024\027\ \027\024\020\024 \007\030\036\027\026\032\026 \r)Tj /Span<>> BDC ( )Tj EMC (\021\036\004\036\027\017\036 )Tj 0 Tw T* (\023\036\030\r\t\b 48 \004\026\f\024\r \r)Tj /Span<>> BDC ( )Tj EMC (\n\017\035\035\017\035\017\021\030\026\b.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\033\030\031\030\217\n)-20.9(\035\210\217\241\003 \013\032)50(\n)42(\032\210\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj -51.938 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 2)69(4, \023\0224, 202)23(5)]TJ 43.013 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 2)69(4, \023\0224, 202)23(5)]TJ /T1_3 1 Tf 25 0 0 25 20.0153 56.0378 Tm (114)Tj ET endstream endobj 1616 0 obj [1622 0 R] endobj 1617 0 obj <>stream q /GS0 gs /Fm0 Do Q 0 0 0 1 K /GS1 gs q 1 0 0 1 42.5197 404.3756 cm 0 0 m 453.543 0 l S Q BT 0 0 0 1 k /T1_0 1 Tf 10 0 0 10 42.5197 724.8299 Tm (https://doi.org/10.33878/2073-7556-2025-24-4-106-119)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0.023 Tw 19 0 0 19 77.1699 695.3259 Tm [(\034\201\025\b\222\016\017)-10(\026\021\r\215\025\016 \025\211\215\025\212\016\215\026\201\025\r\025\016\ \215\001\235\t\205\211\001\026)11(\016\t\214\215\025\016 )]TJ 1.724 -1.105 Td [(\021\b\b)-10(\t\016\211\025\r\001\215\021\016 \242\215\016\201\202)10(\016\026\021\f\016\b\017\021 \200\b)-10(\026\201\025\207\b)-9.9(\026\r )]TJ 2.608 -1.105 Td [(\r\022)-23.3(\017)10(\025\t\025\201\016\017)-10(\026)11(\001\t\214\215\025\207 \021\201\200\201\202\021\021)]TJ 17 0 0 17 62.5345 626.6566 Tm [(\(\222\016\201\016\r\025\211 \b)-10(\026)11(\001\026\214\021 \253A Pr)20(ospectiv)12.1(e Single Centr)31(e Obser)-20.9(v)10(ational )]TJ 2.448 -1.235 Td [(Study on\022)-23.2(Ener)31(gy\022)-23.3(De)11(vices in\022)-23.3(Color)31(ectal\022)-23.3(Sur)31(ger)-31(y\273\))]TJ 0 0 0 1 k /GS1 gs 14 0 0 14 42.5197 581.1526 Tm [(Joanna\022)-23.2(Sander)-21(w)20(ale, Annappa\022)-23.2(K)31(udv)10(a, Jithin A)-31(. Jacob)]TJ 10 0 0 10 42.5197 563.4834 Tm [(K)41(asturba Medical college, MAHE, Manipal, K)41(arnataka, India)]TJ 0 Tw ( )Tj 0.023 Tw 0 -1.2 TD [(\(\222\016\201\016\r\025\211\022)-23.2(\231 \007\025\b\017\001\t\016\r \n)-31(.\030.\))]TJ /T1_0 1 Tf 0.121 Tw 9 0 0 9 90.7087 532.9795 Tm (\221\204\231\232: \034\007\016\020\022\035\003 \f\033\022\006\016\020\016\ \020\022\016 \023\027\003\035\033\037\031\036\023\021\034\036\034\013\034\ \024\021\037\027\003\f\016\027\030 \022)Tj /Span<>> BDC ( )Tj EMC (\220\027\016\021\035\033\034\021\034\037\013\023\027\030\007\022\022 \036\ )Tj /Span<>> BDC ( )Tj EMC (\021\034\027\034\033\016\021\035\037\027\003\020\034\004 \002\022\033\023\ \033\013\022\022 )Tj 0.023 Tw 0 -1.111 TD (\b\027\030 \f\033\022\020\030\035\022\030 \034\025\034\024\020\034\036\037\ \020\020\032\002 \033\016\001\016\020\022\004 \022)Tj /Span<>> BDC ( )Tj EMC (\033\037\031\033\037\025\034\035\021\022 \020\037\022\027\023\005\001\022\ \002 \006\016\035\034\b\034\036.)Tj 0.202 Tw T* (\t\205\221\200\204\217\202\233 \200)Tj /Span<>> BDC ( )Tj EMC (\214\204\202\240\n\233: \f\033\034\024\f\016\021\035\022\036\020\034\016\ \020\037\025\027\026\b\037\035\016\027\003\020\034\016 \022\024\024\027\ \016\b\034\036\037\020\022\016 \036)Tj /Span<>> BDC ( )Tj EMC (\007\016\020\035\033\016 \035\033\016\035\003\016\013\034 \023\033\034\036\ \020\030 \006\016\b\022)Tj 0 Tw (-)Tj 0.286 Tw T* (\007\022\020\024\021\034\004 \f\034\006\034\235\022 \(19.12.2022\22630.0\ 9.2024\). \n\037\020\020\032\016 \024\034\025\033\037\020\032 \022)Tj /Span<>> BDC ( )Tj EMC (\f\033\034\037\020\037\027\022\031\022\033\034\036\037\020\032 \024)Tj /Span<>> BDC ( )Tj EMC (\f\034\006\034\235\003\026 SPSS 23. )Tj 0.023 Tw T* (\200\024\024\027\016\b\034\036\037\020\022\016 \034\b\034\025\033\016\020\ \034 \(IEC2:474/2022\) \022)Tj /Span<>> BDC ( )Tj EMC (\031\037\033\016\013\022\024\035\033\022\033\034\036\037\020\034 \(CTRI/\ 2022/12/048254\).)Tj 0.064 Tw 0 -1.111 TD (\213\204\255\215\231\232\202\205\202\233: \013\033\023\f\f\032 \024\034\f\ \034\024\035\037\036\022\006\032 \f\034)Tj /Span<>> BDC ( )Tj EMC (\022\024\002\034\b\020\032\006 \002\037\033\037\021\035\016\033\022\024\035\ \022\021\037\006. \217\016 \036\032\030\036\027\016\020\034 \031\020\037\ \005\022\006\032\002 \033\037\031\027\022\005\022\004 \036)Tj /Span<>> BDC ( )Tj EMC (\f\033\034)Tj 0 Tw (-)Tj 0.091 Tw 0 -1.111 TD (\b\034\027\201\022\035\016\027\003\020\034\024\035\022 \034\f\016\033\037\ \007\022\022, \022\020\035\033\037\034\f\016\033\037\007\022\034\020\020\ \032\006 \021\033\034\036\034\035\016\005\016\020\022\030\006, \034\035\b\ \016\027\030\016\006\034\016 \f\034)Tj /Span<>> BDC ( )Tj EMC (\b\033\016\020\037\201\023 \(48 \005\) \022)Tj /Span<>> BDC ( )Tj EMC (\021\034\004\021\034-)Tj 0.023 Tw T* (\b\020\026 \006\016\201\b\023 \013\033\023\f\f\037\006\022.)Tj 0.002 Tw T* [(\233\240\n: )0.6(\023\027\003\035\033\037\031\036\023\021\034\036\034\004 )0.6(\024\021\037\027\003\f\016\027\003 )0.6(\022)]TJ /Span<>> BDC ( )Tj EMC 15.484 0 Td [(\220\027\016\021\035\033\034\021\034\037\013\023\027\030\007\022\030 )0.7(\030\036\027\030\026\035\024\030 )0.6(\007\016\020\020\032\006\022 )0.5(\022\020\024\035\033\023\006\016\020\035\037\006\022 )0.6(\b\027\030 )0.6(\b\022\024\024\016\021\007\022\022 )]TJ 0.016 Tw -15.484 -1.111 Td (\022)Tj /Span<>> BDC ( )Tj EMC (\013\016\006\034\024\035\037\031\037 \036)Tj /Span<>> BDC ( )Tj EMC (\021\034\027\034\033\016\021\035\037\027\003\020\034\004 \002\022\033\023\ \033\013\022\022, \005\035\034 \021\033\022\035\022\005\016\024\021\022 \ \036\037\201\020\034 \b\027\030 \220\017\017\016\021\035\022\036\020\032\ \002 \022)Tj /Span<>> BDC ( )Tj EMC (\025\016\031\034\f\037\024\020\032\002 \006\037\027\034\022\020\036\037)Tj 0 Tw (-)Tj 0.023 Tw T* (\031\022\036\020\032\002 \f\034\b\002\034\b\034\036. \217\016\034\025\002\ \034\b\022\006\034 \034\007\016\020\022\035\003 \034\035\b\037\027\016\020\ \020\032\016 \033\016\031\023\027\003\035\037\035\032.)Tj /T1_2 1 Tf 0.01 Tc -0.01 Tw 8 0 0 8 42.5596 417.7102 Tm [(KEYW)22(ORDS:)]TJ /T1_0 1 Tf 0 Tc 0.023 Tw 4.948 0 Td [( har)-14(monic, electrosurg)12.1(er)-43(y)42(, colorectal, monopolar)]TJ 0 Tw -4.953 -3.147 Td (\n\037\035\037 \f\034\024\035\023\f\027\016\020\022\030)Tj /Span<>> BDC ( )Tj EMC (\227 04.08.2025)Tj /Span<>> BDC ( )Tj EMC 19.488 0 Td (\t\034\024\027\016 \b\034\033\037\025\034\035\021\022)Tj /Span<>> BDC ( )Tj EMC (\227 01.09.2025)Tj /Span<>> BDC ( )Tj EMC 18.78 0 Td (\t\033\022\020\030\035\034 \021)Tj /Span<>> BDC ( )Tj EMC (\f\023\025\027\022\021\037\007\022\022)Tj /Span<>> BDC ( )Tj EMC (\227 10.11.2025)Tj ( )Tj -38.268 -1.375 Td (Received)Tj /Span<>> BDC ( )Tj EMC (\227 04.08.2025)Tj /Span<>> BDC ( )Tj EMC 19.488 0 Td (Revised)Tj /Span<>> BDC ( )Tj EMC (\227 01.09.2025)Tj /Span<>> BDC ( )Tj EMC 18.78 0 Td (Accepted for publication)Tj /Span<>> BDC ( )Tj EMC (\227 10.11.2025)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 42.5896 347.3119 Tm (\023\023\034\226\034\022\031\034)Tj 0 0 0 1 k /GS1 gs /T1_4 1 Tf 0 Tc 0.121 Tw 10 0 0 10 42.5197 322.9559 Tm (\215\024\027\017\n\026\027\017\036 \026\027\026\021\024\n\017\017 \017)Tj /Span<>> BDC ( )Tj EMC (\220\n\002\030\017\024\035\024\020\017\017 \021\024\035\f\021\024\005 \022\ \017\001\022\017 )Tj 0.079 Tw 0 -1.218 TD (\027\036\024\002\b\024\007\017\n\024 \007\035\016 \023\024\027\017\n\026\ \027\017\016 \023\026\021\024\235\017\017\024\035\024\020\017\017 \036\201\ \030\026)Tj 0 Tw (-)Tj 0.325 Tw T* (\035\017\004\027\t\b \026\002\024\035\036\r\026\027\017\005 \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\r\036\007\036\027\017\016 \b\017\030\031\030\020\017\004\036\ \f\022\017\b )Tj 0.11 Tw T* (\r\n\036\001\026\021\036\035\034\f\021\r. \025\024\035\024\030\036\022\021\ \026\035\034\027\t\036 \024\023\036\030\026\006\017\017 \004\026\f\021\024\ \021\030\036)Tj 0 Tw (-)Tj 0.175 Tw T* (\002\031\033\021 \030\036\036\022\006\017\017 \031\004\026\f\021\022\024\ \r \021\024\035\f\021\024\005 \022\017\001\022\017 \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\007\026\027\017\016 )Tj 0.171 Tw T* (\026\027\026\f\021\024\n\024\026 \007\035\016 \r\024\f\f\021\026\027\024\ \r\035\036\027\017\016 \027\036\023\030\036\030\t\r\027\024\f\021\017 \022\ \017)Tj 0 Tw (-)Tj 0.265 Tw T* (\001\036\004\027\017\022\026. \200\t\002\024\030 \n\036\032\007\031 \035\ \026\023\026\030\024\f\022\024\023\017\004\036\f\022\017\n \017)Tj /Span<>> BDC ( )Tj EMC (\021\030\026)Tj 0 Tw (-)Tj 0.406 Tw T* (\007\017\006\017\024\027\027\t\n \b\017\030\031\030\020\017\004\036\f\022\ \017\n \023\024\007\b\024\007\026\n\017 \026\r\017\f\017\021 \024\021 )Tj 0.18 Tw T* (\n\027\024\032\036\f\021\r\026 \235\026\022\021\024\030\024\r, \r\022\035\ \033\004\026\016 \024\023\t\021 \b\017\030\031\030\020\026 \017)Tj /Span<>> BDC ( )Tj EMC (\024\f\024)Tj 0 Tw (-)Tj T* (\002\036\027\027\024\f\021\036\005 \023\026\006\017\036\027\021\026.)Tj 0.449 Tw T* [(\212\024\f\021\017\032\036\027\017\016 )0.6(\r)]TJ /Span<>> BDC ( )Tj EMC 6.894 0 Td [(\b\017\030\031\030\020\017\004\036\f\022\024\005 )0.6(\021\036\b\027\017\022\036, )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 12.103 0 Td (\004\026\f\021\027\024)Tj 0 Tw (-)Tj 0.215 Tw -18.997 -1.218 Td [(\f\021\017, \017\f\023\024\035\034\024\r\026\027\017\036 \220\027\036\030\ \020\036\021\017\004\036\f\022\017\b )0.5(\031\f\021\030\024\005\f\021\r, \023\030\024)]TJ 0 Tw (-)Tj 0.566 Tw T* (\017\r\036\035\017 \030\036\r\024\035\033\006\017\033 \r)Tj /Span<>> BDC ( )Tj EMC (\022\024\035\024\030\036\022\021\026\035\034\027\024\005 \b\017\030\031\030\ \020\017\017. )Tj 0.569 Tw T* (\225\035\036\022\021\030\024\b\017\030\031\030\020\017\016, \017\f\023\024\ \035\034\031\033\013\026\016 \r\t\f\024\022\024\004\026\f\021\024\021\027\ \t\005 )Tj 0.037 Tw T* (\220\035\036\022\021\030\017\004\036\f\022\017\005 \021\024\022, \017)Tj /Span<>> BDC ( )Tj EMC (\031\035\034\021\030\026\r\031\022\024\r\t\036 \031\f\021\030\024\005\f\ \021\r\026, \017\f)Tj 0 Tw (-)Tj 0.276 Tw T* (\023\024\035\034\031\033\013\017\036 \n\036\b\026\027\017\004\036\f\022\ \031\033 \220\027\036\030\020\017\033, \024\002\036\f\023\036\004\017\r\026\ \033\021 )Tj 0.086 Tw T* (\021\024\004\027\024\036 \030\026\f\f\036\004\036\027\017\036 \021\022\026\ \027\036\005 \017)Tj /Span<>> BDC ( )Tj EMC (\220\235\235\036\022\021\017\r\027\t\005 \020\036\n\024\f\021\026. )Tj 0.601 Tw T* [(\204\024\027\024\023\024\035\016\030\027\026\016 )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC 8.259 0 Td [(\002\017\023\024\035\016\030\027\026\016 )0.5(\220\035\036\022\021\030\024\022\024\026\020\031\035\016\006\017\016, )]TJ 0.03 Tw -8.259 -1.218 Td (\026)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\032\036 \021\026\022\017\036 \023\036\030\036\007\024\r\t\036\ \f\017\f\021\036\n\t, \022\026\022 \f\017\f\021\036\n\026 \030\026\007\017\ )Tj 0 Tw (-)Tj 0.125 Tw T* (\024\004\026\f\021\024\021\027\024\005 \020\036\030\n\036\021\017\026\006\ \017\017 \f\024\f\031\007\024\r \017)Tj /Span<>> BDC ( )Tj EMC (\031\035\034\021\030\026\r\031\022\024\r\024\005 )Tj 0.091 Tw T* (\f\022\026\035\034\023\036\035\034, \023\024\r\t\f\017\035\017 \002\036\ \024\023\026\f\027\024\f\021\034 \017)Tj /Span<>> BDC ( )Tj EMC (\220\235\235\036\022\021\017\r\027\024\f\021\034 )Tj 0.221 Tw 23.244 26.792 Td (\b\017\030\031\030\020\017\004\036\f\022\017\b \r\n\036\001\026\021\036\035\ \034\f\021\r. \225\021\017 \031\f\021\030\024\005\f\021\r\026 \024\002\035\ \026)Tj 0 Tw (-)Tj 0.057 Tw T* [(\007\026\033\021 )0.5(\016\r\027\t\n\017 )0.6(\023\030\036\017\n\031\013\036\f\021\r\026\n\017 )0.6(\r)]TJ /Span<>> BDC ( )Tj EMC 13.798 0 Td [(\024\002\035\026\f\021\017 )0.6(\030\026\f\f\036\004\036\027\017\016 )]TJ 0.043 Tw -13.798 -1.218 Td (\021\022\026\027\036\005 \017)Tj /Span<>> BDC ( )Tj EMC (\020\036\n\024\f\021\026\026, \004\021\024 \022\030\017\021\017\004\036\ \f\022\017 \r\026\032\027\024 \007\035\016 \n\017\027\017)Tj 0 Tw (-)Tj 0.129 Tw T* (\n\017\026\006\017\017 \017\027\021\030\026\024\023\036\030\026\006\017\ \024\027\027\024\005 \022\030\024\r\024\023\024\021\036\030\017 \017)Tj /Span<>> BDC ( )Tj EMC (\f\027\017\032\036)Tj 0 Tw (-)Tj T* (\027\017\016 \023\024\f\035\036\024\023\036\030\026\006\017\024\027\027\t\ \b \024\f\035\024\032\027\036\027\017\005.)Tj 0.249 Tw T* [(\211\035\034\021\030\026\r\031\022\024\r\024\005 )0.6(\f\022\026\035\034\023\036\035\034 )0.5(\017\f\023\024\035\034\031\036\021 )0.6(\031\035\034\021\030\026\r\031\022\024)]TJ 0 Tw (-)Tj 0.158 Tw T* (\r\031\033 \220\027\036\030\020\017\033 \007\035\016 \024\007\027\024\r\030\ \036\n\036\027\027\024\020\024 \030\026\030\036\026 \017)Tj /Span<>> BDC ( )Tj EMC (\022\024\026\020\031)Tj 0 Tw (-)Tj 0.356 Tw T* (\035\016\006\017\017 \021\022\026\027\036\005, \024\002\036\f\023\036\004\ \017\r\026\016 \031\027\017\022\026\035\034\027\024\036 \f\024\004\036\021\ \026\027\017\036 )Tj 0.054 Tw T* (\n\036\b\026\027\017\004\036\f\022\024\005 \017)Tj /Span<>> BDC ( )Tj EMC (\021\036\023\035\024\r\024\005 \220\027\036\030\020\017\017, \004\021\024\ \024\002\036\f\023\036\004\017\r\026\036\021 )Tj 0.137 Tw T* [(\021\024\004\027\031\033 )0.5(\024\002\030\026\002\024\021\022\031 )0.6(\021\022\026\027\036\005 )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC 11.959 0 Td [(\n\017\027\017\n\026\035\034\027\t\n )0.6(\035\026\021\036\030\026\035\034)]TJ 0 Tw (-)Tj 0.015 Tw -11.959 -1.218 Td (\027\t\n \021\036\030\n\017\004\036\f\022\017\n \023\024\r\030\036\032\007\ \036\027\017\036\n. \200)Tj /Span<>> BDC ( )Tj EMC (\024\021\035\017\004\017\036 \024\021 \220\021\024\020\024, )Tj 0.332 Tw T* (\220\035\036\022\021\030\024\022\024\026\020\031\035\016\006\017\016, \022\ \024\021\024\030\026\016 \n\024\032\036\021 \017\f\023\024\035\034\024\r\ \026\021\034\f\016 )Tj -0.022 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC 0.684 0 Td [(\n\024\027\024\023\024\035\016\030\027\024\n )0.6(\017\035\017 )0.5(\002\017\023\024\035\016\030\027\024\n )0.5(\030\036\032\017\n\026\b, )0.6(\017\f\023\024\035\034\031)]TJ 0 Tw (-)Tj -0.015 Tw -0.684 -1.218 Td (\036\021 \r\t\f\024\022\024\004\026\f\021\024\021\027\t\036 \220\035\036\ \022\021\030\017\004\036\f\022\017\036 \021\024\022\017 \007\035\016 \030\ \026\f\f\036\004\036)Tj 0 Tw (-)Tj 0.02 Tw T* (\027\017\016 \021\022\026\027\036\005 \017)Tj /Span<>> BDC ( )Tj EMC (\020\036\n\024\f\021\026\026 \023\024\f\030\036\007\f\021\r\024\n \022\024\ \027\021\030\024\035\017\030\031\036\n\024)Tj 0 Tw (-)Tj 0.098 Tw T* (\020\024 \021\036\030\n\017\004\036\f\022\024\020\024 \r\024\007\036\005\ \f\021\r\017\016. \210\002\036 \021\036\b\027\024\035\024\020\017\017 \f\ \021\026\035\017 )Tj 0.342 Tw T* (\027\036\024\021\255\036\n\035\036\n\024\005 \004\026\f\021\034\033 \f\024\ \r\030\036\n\036\027\027\024\005 \b\017\030\031\030\020\017\004\036\f\022\ \024\005 )Tj 0.21 Tw T* (\023\030\026\022\021\017\022\017, \024\007\027\026\022\024 \017\b \f\030\ \026\r\027\017\021\036\035\034\027\026\016 \220\235\235\036\022\021\017\r\ \027\024\f\021\034 )Tj 0.034 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\002\036\024\023\026\f\027\024\f\021\034 \r)Tj /Span<>> BDC ( )Tj EMC (\022\024\035\024\030\036\022\021\026\035\034\027\024\005 \b\017\030\031\030\ \020\017\017 \024\f\021\026\033\021\f\016 )Tj 0 Tw T* (\023\030\036\007\n\036\021\024\n \026\022\021\017\r\027\t\b \017\f\f\035\ \036\007\024\r\026\027\017\005.)Tj 0.46 Tw T* (\037\036\035\034 \007\026\027\027\024\020\024 \027\026\002\035\033\007\026\ \021\036\035\034\027\024\020\024 \017\f\f\035\036\007\024\r\026\027\017\016\ )Tj /Span<>> BDC ( )Tj EMC (\227 )Tj 0.669 Tw T* (\024\006\036\027\017\021\034 \023\030\017\n\036\027\036\027\017\036 \031\ \035\034\021\030\026\r\031\022\024\r\024\020\024 \f\022\026\035\034\023\ \036\035\016 )Tj 0.318 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\220\035\036\022\021\030\024\022\024\026\020\031\035\016\021\024\030\026\ \r)Tj /Span<>> BDC ( )Tj EMC (\022\024\035\024\030\036\022\021\026\035\034\027\024\005 \b\017\030\031\030\ \020\017\017, )Tj ET 1 0.68 0 0.12 k /GS0 gs q 1 0 0 1 42.5197 541.4839 cm 0 0 m 0 0 l 0 -11.339 l 42.52 -11.339 l 42.52 0 l h f Q BT 0 0 0 0 k /T1_2 1 Tf 0 Tw 9 0 0 9 47.6607 532.5566 Tm (\027\030\013\016\n\030)Tj 1 0.68 0 0.12 k /T1_1 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\034\201\025\b\222\016\017)-9.9(\026\021\r\215\025\016 \025\211\215\025\212\016\215\026\201\025\r\025\016\ \215\001\235\t\205\211\001\026)11(\016\t\214\215\025\016 \021\b\b)-10(\t\016\211\025\r\001\215\021\016 )]TJ 0 -1 TD [(\242\215\016\201\202)10(\016\026\021\f\016\b\017\021 \200\b)-10(\026\201\025\207\b)-10(\026\r \r\022\017)10(\025\t\025\201\016\017)-10(\026)11(\001\t\214\215\025\207 \021\201\200\201\202\021\021)]TJ 41.119 1 Td [(A Pr)20(ospectiv)12(e Single Centr)31(e Obser)-20.9(v)10(ational Study )]TJ 3.383 -1 Td [(on\022Ener)31.1(gy\022De)11(vices in Color)31(ectal Sur)31(ger)-31(y)]TJ -44.502 96.622 Td [(\036\033\030\031\030\217\n)-20.9(\035\210\217\241\003 \013\032)50(\n)42(\032\210\030)]TJ 51.938 0 Td (ORIGINAL 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J)-6(i)-6(t)-16.6(h)-4.2(i)7.2(n A)-19.1(b)-4(r)-21.5(a)1.2(h)1.8(am J)4.6(a)-1.2(c)3.7(o)-1.6(b)]TJ /Span<>> BDC ( )Tj EMC [(\227 w)-3.6(o)-1.9(r)-21.4(k)-32.1(i)7.1(n)-1.9(g a)-17.1(s A)-27.3(s)-12.8(s)-16.6(i)2.8(s)-20(t)-27.7(a)2.4(n)-7.5(t )]TJ 0.278 Tw T* [(p)-3.8(r)-6(o)-2.2(f)-19.1(e)-13.3(s)-12.8(s)-9.4(o)-1.9(r i)7.1(n t)-16.7(h)-5.3(e)]TJ /Span<>> BDC ( )Tj EMC [(D)-12.2(e)-0.7(p)-10.4(ar)-51.4(t)-16.6(m)-6.8(e)-1.6(n)-7.5(t o)-2.2(f)]TJ /Span<>> BDC ( )Tj EMC [(G)-8.7(e)-1.6(n)-6.3(e)-2.1(r)-21.5(a)-1.5(l S)-2.2(u)2.5(r)-7(g)-4.5(e)-2.1(r)-52.4(y a)-8.4(t )]TJ 0.101 Tw T* [(K)-16.1(M)3.7(C)-38.2(, M)1.3(a)2.5(n)-4.2(i)7.7(p)-10.4(a)-1.5(l)-22.5(. A)4.6(f)-56.3(\251)3.9(l)-6.9(i)5.1(a)-8.4(t)-15.2(e)-11.3(d t)-12.3(o)]TJ /Span<>> BDC ( )Tj EMC [(a)2.4(n i)7.1(n)-1.2(s)-20(t)-37.4(i)-6(t)-12.8(u)-6.5(t)-15.2(e w)-36.9(i)-5.9(t)-16.7(h h)-4.1(i)3.2(g)1(h r)-9.4(e)]TJ 0 Tw 21.758 0 Td (-)Tj 0.147 Tw -21.758 -1.218 Td [(g)2(ar)-8.5(d f)-15.6(o)-1.9(r r)-9.4(e)-13.3(s)-13.2(e)-3.1(ar)-1.6(ch a)2.4(n)-4.6(d p)-6.7(u)-3.6(b)-8.5(l)-7(i)5.2(c)-11.8(a)-8.4(t)-37.3(i)3.2(o)0.8(n)-1.2(s)-29(, K)-21(a)-17.1(s)-20(t)-12.8(u)2.4(r)-19.1(b)-7.9(a M)-2.5(e)-11.3(d)-6(i)5.2(c)-11.8(a)-1.5(l )]TJ 0.527 Tw 0 -1.218 TD [(c)3.7(o)-5.8(l)-19(l)-14.3(e)-11.3(g)-4.5(e)-19.8(, M)-10.8(A)0.7(H)13.3(E)-22.5(, M)1.3(a)2.4(n)-4.1(i)7.6(p)-10.4(a)-1.5(l)-51.9(, K)-21(ar)-26.8(n)2.2(a)-8.4(t)-27.7(a)-1.2(k)-14.7(a)-27.9(, I)4.6(n)-4.6(d)-6(i)5.1(a)5.6(; O)1.9(RC)-26.3(I)8.9(D )]TJ 0.014 Tc -0.014 Tw 0 -1.218 TD [(0000)-10.2(-)-9.8(000)20.6(2)37(-)67(7)35(2)29.7(7)19.6(7)61.8(-)67(7)35.1(2)18.1(9)20.6(5)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 70.936 554.3379 Tm (REFERENCES)Tj 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0 Tc -0.002 Tw 8 0 0 8 70.8661 541.5032 Tm (1.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Ho)17(t)-30(t)15(a)]TJ /Span<>> BDC ( )Tj EMC 2.506 0 Td [(T, )0.5(T)40(ak)-16(ifuji)]TJ /Span<>> BDC ( )Tj EMC 4.124 0 Td [(K, )0.5(Y)40(okoy)22(ama)]TJ /Span<>> BDC ( )Tj EMC 5.122 0 Td [(S, )0.5(Ma)15(tsud)42(a)]TJ /Span<>> BDC ( )Tj EMC 4.404 0 Td [(K, )0.5(e)-11.9(t)]TJ /Span<>> BDC ( )Tj EMC 1.995 0 Td [(al. )0.6(L)-32(i)-24(ter)-33(a)15(tur)-23.9(e )0.5(r)-24(ev)-15.9(iew )]TJ -0.015 Tw -19.447 -1.25 Td (of)Tj /Span<>> BDC ( )Tj EMC [(t)-12.9(he ener)-32(g)16(y sour)-31.9(ces for per)-23.9(for)-16(ming l)-15.9(ap)32(ar)-32(oscopic col)30(or)-23.9(ec)-16(t)15(al sur)-31.9(ger)-24(y. )]TJ /T1_3 1 Tf 0.129 Tw 0 -1.25 TD [(W)29(orld J Gastrointest Surg.)]TJ /T1_0 1 Tf ( 2012 Jan 27;4\(1\):1\2268. PMID: 22347536; )Tj 0.023 Tw T* (PMCID: PMC3277876.)Tj 0.337 Tw T* (2.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Cam)10(p)32(a)-17(gna)-17(cc)-24(i)]TJ /Span<>> BDC ( )Tj EMC [(R, de Sanc)-15.9(t)-32(is)]TJ /Span<>> BDC ( )Tj EMC [(A, Bald)42(ar)-24(ell)-30.9(i)]TJ /Span<>> BDC ( )Tj EMC [(M, R)-24(imini)]TJ /Span<>> BDC ( )Tj EMC [(M, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC (al. )Tj 0.039 Tw -1.296 -1.25 Td [(Elec)-16(tr)-31.9(o)17(t)-13(her)-16(mal bipol)-16(ar vessel seal)-30.9(ing dev)-16(ice vs. ul)56(tr)-32.9(asonic coa)-16.9(gul)-16(a)15(t)]TJ 0 Tw (-)Tj 0.162 Tw T* [(ing shear)-9.9(s in l)-16(ap)32(ar)-32(oscopic colec)-16(t)17(omies: a)]TJ /Span<>> BDC ( )Tj EMC [(com)10(p)32(ar)-33(a)15(t)-32(i)-16(ve stud)17.1(y. )]TJ /T1_3 1 Tf 0 Tw (Surg )Tj T* (Endosc.)Tj /T1_0 1 Tf -0.03 Tw [( 2007 Sep;21\(9\):1526\22631. Epub 2007 F)10(eb 8. PMID: 17287913.)]TJ 0.207 Tw T* (3.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(T)40(ak)-17(ad)42(a)]TJ /Span<>> BDC ( )Tj EMC [(M, Ichihar)-33(a)]TJ /Span<>> BDC ( )Tj EMC [(T, K)25(ur)-32(od)42(a)]TJ /Span<>> BDC ( )Tj EMC [(Y. Com)10(p)32(ar)-33(a)15(t)-32(i)-16(ve stud)17(y of)]TJ /Span<>> BDC ( )Tj EMC [(elec)-15.9(tr)-32(o)]TJ 0 Tw (-)Tj 0.17 Tw -1.296 -1.25 Td [(t)-13(her)-16(mal bipol)-15.9(ar vessel sealer and ul)56(tr)-33(asonic coa)-17(gul)-15.9(a)15(t)-32(ing shear)-10(s in )]TJ 0.155 Tw T* [(l)-16(ap)32(ar)-32(oscopic colec)-15.9(t)17(omy. )]TJ /T1_3 1 Tf (Surg Endosc.)Tj /T1_0 1 Tf [( 2005 F)10(eb;19\(2\):226\2268. Epub )]TJ 0.023 Tw T* (2004 Dec 2. PMID: 15573241.)Tj -0.003 Tw T* (4.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(T)40(ar)-32(gar)-32(ona)]TJ /Span<>> BDC ( )Tj EMC [(EM, Bal)-15.9(a)-17(gue)]TJ /Span<>> BDC ( )Tj EMC [(C, Mar)-37(in)]TJ /Span<>> BDC ( )Tj EMC [(J, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Ener)-31.9(g)16(y sour)-31.9(ces for l)-16(ap)32(ar)-32(o)]TJ 0 Tw (-)Tj 0.065 Tw -1.296 -1.25 Td [(scopic colec)-15.9(t)17(omy: a)]TJ /Span<>> BDC ( )Tj EMC [(p)25(r)-32(ospec)-16(t)-32(i)-16(ve r)-33(and)-16(omized com)10(p)32(ar)-37(ison of)]TJ /Span<>> BDC ( )Tj EMC (conven)Tj 0 Tw (-)Tj 0.322 Tw T* [(t)-32(ional elec)-15.9(tr)-32(osur)-32(ger)-23.9(y, bipol)-16(ar com)10(puter-contr)-31.9(olled elec)-16(tr)-32(osur)-31.9(ger)-24(y )]TJ 0.233 Tw 29.055 17.5 Td [(and )0.6(ul)56(tr)-33(asonic )0.6(dissec)-16(t)-32(ion. )0.6(Oper)-33(a)15.1(t)-32(i)-16(ve )0.5(outcome )0.6(and )0.6(costs )0.6(anal)35(y)-13(sis. )]TJ /T1_3 1 Tf 0.023 Tw T* (Surg Innov.)Tj /T1_0 1 Tf ( 2005 Dec;12\(4\):339\22644.)Tj 0.01 Tc 0.363 Tw T* (5.)Tj /Span<>> BDC ( )Tj EMC 1.325 0 Td [(S)-15.7(ist)15.3(a)]TJ /Span<>> BDC ( )Tj EMC [(F, A)-13.7(br)-21.7(uz)-23.7(zese)]TJ /Span<>> BDC ( )Tj EMC [(V, S)-23.7(chie)-11.7(tr)-31.7(oma)]TJ /Span<>> BDC ( )Tj EMC [(M, e)-11.7(t)]TJ /Span<>> BDC ( )Tj EMC [(al. New Ul)56.3(tr)-32.7(asonic)10( )]TJ 0 Tc 0.307 Tw -1.325 -1.25 Td [(S)-24(calpel ver)-9.9(sus Convent)-32(ional Hemost)15(asis in R)-24(ight Col)30(on Sur)-32(ger)-24(y: )]TJ -0.015 Tw T* (A)Tj /Span<>> BDC ( )Tj EMC [(P)35(r)-32(ospec)-16(t)-31.9(i)-16(ve R)-10(and)-16(omized Contr)-31.9(olled Cl)-31(inical T)50(r)-37(ial. )]TJ /T1_3 1 Tf (Dig Surg.)Tj /T1_0 1 Tf [( 1 Mar)-32(ch )]TJ 0.023 Tw T* (2014; 30 \(4-6\): 355\226361.)Tj 0.01 Tw T* (6.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(R)-24(imond)42(a)]TJ /Span<>> BDC ( )Tj EMC 3.733 0 Td [(R, )0.5(Ar)-23.9(ez)-24(zo)]TJ /Span<>> BDC ( )Tj EMC 3.919 0 Td [(A, )0.5(Gar)-23.9(r)-32(one, )0.5(e)-12(t)]TJ /Span<>> BDC ( )Tj EMC 5.654 0 Td [(al. )0.5(Elec)-15.9(tr)-32(o)17(t)-13(her)-15.9(mal )0.5(Bipol)-16(ar )0.6(V)30(essel )]TJ 0.002 Tc 0.35 Tw -14.603 -1.25 Td [(Seal)-31.4(ing Sy)-13.4(stem vs. Ul)55.6(tr)-33.4(asonicS)-24.5(calpel in Col)29.6(or)-24.4(ec)-16.4(t)14.5(al L)-32.4(ap)31.6(ar)-32.4(oscopic)2( )]TJ 0 Tc 0.126 Tw T* [(Sur)-32(ger)-23.9(y: A)]TJ /Span<>> BDC ( )Tj EMC [(P)35(r)-32(ospec)-16(t)-32(i)-16(ve, R)-10(and)-16(omized S)15(tud)17(y. )]TJ /T1_3 1 Tf (Diseases of)Tj /Span<>> BDC ( )Tj EMC (the Colon & )Tj 0 Tw T* [(R)21(ectum.)]TJ /T1_0 1 Tf 0.023 Tw [( 52\(4\):p 657-661, Ap)25(r)-36.9(il 2009. |)]TJ 0.011 Tw T* (7.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(K)-16(al)-15.9(ar)-37(i)]TJ /Span<>> BDC ( )Tj EMC [(P, Nir)-24(hale)]TJ /Span<>> BDC ( )Tj EMC [(DS, V)25(ajja)]TJ /Span<>> BDC ( )Tj EMC [(R, Gal)-16(am)]TJ /Span<>> BDC ( )Tj EMC [(P. Com)10(p)32(ar)-37(ison of)]TJ /Span<>> BDC ( )Tj EMC [(Convent)-32(ional )]TJ -0.015 Tw -1.296 -1.25 Td [(Bipol)-16(ar Elec)-16(tr)-31.9(o)-16(cauter)-24(y and Ul)56(tr)-32.9(asonic Ul)56.1(tr)-33(asonic S)-24(calpel in Col)30(or)-23.9(ec)-16(t)15(al )]TJ 0.013 Tc 0.489 Tw T* [(Cancer Sur)-32.2(ger)-37.3(ies. )]TJ /T1_3 1 Tf -0.013 Tw (Cureus)Tj /T1_0 1 Tf 0.49 Tw [(. )0.6(2022 )0.6(Mar )0.6(17;14\(3\):e23255. )0.5(PMID:)13( )]TJ 0 Tc 0.023 Tw T* (35449609; PMCID: PMC9012577)Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 0 Tw 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\033\030\031\030\217\n)-20.9(\035\210\217\241\003 \013\032)50(\n)42(\032\210\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj -51.938 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 2)69(4, \023\0224, 202)23(5)]TJ 43.013 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 2)69(4, \023\0224, 202)23(5)]TJ /T1_5 1 Tf 25 0 0 25 19.9277 56.0378 Tm (112)Tj ET endstream endobj 1614 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.445 Tw 10 0 0 10 42.5197 724.8299 Tm [(T)47(his stud)17(y com)10(p)32(ar)-24(ed outcomes be)-12(t)-32(ween t)-13(he)]TJ /Span<>> BDC ( )Tj EMC (New )Tj 0.051 Tw 0 -1.218 TD [(Ul)56(tr)-33(asonic S)-24(calpel \(NUS\) and Convent)-31.9(ional Hemost)15(asis )]TJ 0 Tw T* (\(CH\) [5].)Tj 0.131 Tw T* [(NUS r)-24(efer)-10(s t)17(o)]TJ /Span<>> BDC ( )Tj EMC (a)Tj /Span<>> BDC ( )Tj EMC [(new US handpiece \(NUS; FOCUS L)35(ong )]TJ 0.135 Tw T* [(Cur)-32(ved S)-16(hear)-9.9(s, Et)-13(hicon End)-16(o-Sur)-32(ger)-23.9(y Inc., Cinc)-24(inna)15(t)-32(i, )]TJ 0.005 Tw T* [(Ohio, )0.5(USA\), )0.5(wi)-23.9(t)-13(h )0.5(a)]TJ /Span<>> BDC ( )Tj EMC 7.435 0 Td [(t)-32(ip )0.5(s)26(maller )0.6(t)-13(han )0.5(5 )0.5(mm, )0.5(t)-13(ha)15.1(t )0.5(has )0.5(been )]TJ 0 Tw -7.435 -1.218 Td [(av)-15(ail)-15.9(able since 2009 [5].)]TJ 0.006 Tw T* [(T)47(hese p)32(a)15(t)-32(ients wer)-23.9(e r)-32.9(and)-16(omized int)17.1(o t)-32(w)-14(o gr)-32(oups based )]TJ 0.266 Tw T* [(on t)-12.9(he)]TJ /Span<>> BDC ( )Tj EMC [(ener)-32(g)16(y dev)-15.9(ice used. T)47(he)]TJ /Span<>> BDC ( )Tj EMC [(NUS gr)-31.9(oup incl)35(ud)]TJ 0 Tw (-)Tj 0.132 Tw T* (ed 108)Tj /Span<>> BDC ( )Tj EMC [(p)32(a)15(t)-32(ients, and t)-12.9(he)]TJ /Span<>> BDC ( )Tj EMC [(CH gr)-32(oup had 103 p)32(a)15(t)-31.9(ients. )]TJ 0.14 Tw T* (A)Tj /Span<>> BDC ( )Tj EMC [(gr)-32(oup of)]TJ /Span<>> BDC ( )Tj EMC [(four consul)56(t)15(ant sur)-31.9(geons wi)-24(t)-13(h tr)-32.9(aining in )]TJ 0.254 Tw T* [(col)30(or)-24(ec)-15.9(t)15(al cancer r)-24(esec)-15.9(t)-32(ions car)-24(r)-37(ied out all sur)-32(gical )]TJ 0.141 Tw 0 -1.218 TD [(p)25(r)-32(o)-16(cedur)-23.9(es in )0.5(an)]TJ /Span<>> BDC ( )Tj EMC [(open )0.5(sur)-32(gical )0.5(se)-12(t)-30(t)-32(ing. )0.5(T)47(he)]TJ /Span<>> BDC ( )Tj EMC [(t)-32(w)-14(o )0.5(sur)]TJ 0 Tw 21.758 0 Td (-)Tj 0.23 Tw -21.758 -1.218 Td [(gical gr)-32(oups wer)-23.9(e com)10(p)32(ar)-23.9(ed r)-24(egar)-24(ding p)32(a)15(t)-32(ients\246 a)-17(ge )]TJ 0.014 Tw 0 -1.218 TD [(\(mean a)-17(ge 64 year)-9.9(s\) and se)-18(x \(113 men, 98 w)-14(omen\), tu)]TJ 0 Tw (-)Tj 0.037 Tw T* [(mor size, l)30(o)-16(ca)15(t)-32(ion, hist)17.1(o)17(t)-10(ype and l)30(o)-16(cal inv)-15(asi)-16(veness as)]TJ 0 Tw (-)Tj T* [(sessed b)12(y Amer)-36.9(ican Joint Cancer Commi)-23.8(t)-30(tee st)15(a)-17(ge [5].)]TJ 0.108 Tw T* [(T)47(he p)32(ar)-33(ame)-11.9(ter)-10(s t)-13(ha)15(t wer)-24(e studied incl)35(uded: oper)-33(a)15(t)-32(i)-16(ve )]TJ 0.176 Tw T* [(t)-32(ime, dr)-33(aina)-17(ge vol)35(ume \(\251r)-10(st 1\2263)]TJ /Span<>> BDC ( )Tj EMC [(d)41.9(a)15.1(y)-13(s af)-28(ter sur)-32(ger)-24(y\), )]TJ 0.09 Tw T* [(hospi)-24(t)15(al st)15(a)15(y and com)10(pl)-31(ica)15.1(t)-32(ions as p)25(r)-37(imar)-24(y outcomes; )]TJ 0.174 Tw T* [(ser)-22(um albumin on post-oper)-32.9(a)15(t)-32(i)-16(ve d)42(a)15(y)-13(s 1, 2, 3, 6 and )]TJ -0.064 Tw T* [(C-r)-24(ea)-17(c)-15.9(t)-32(i)-16(ve )0.5(p)25(r)-32(o)17(tein )0.5(\(CRP\) )0.6(on )0.5(post-oper)-33(a)15(t)-32(i)-15.9(ve )0.5(d)42(a)15(y)-13(s )0.5(1, )0.5(2, )0.5(3, )0.5(6 )]TJ 0.051 Tw T* [(as second)42(ar)-24(y outcomes. P)10.1(ost-oper)-33(a)15(t)-32(i)-16(ve ser)-22(um albumin )]TJ 0.123 Tw T* [(concentr)-33(a)15(t)-31.9(ion w)-12(as measur)-23.9(ed t)17(o)]TJ /Span<>> BDC ( )Tj EMC [(de)-12(tec)-16(t p)25(r)-32(o)17(tein deple)]TJ 0 Tw (-)Tj 0.13 Tw T* [(t)-32(ion due t)17(o)]TJ /Span<>> BDC ( )Tj EMC [(l)35(ym)10(phor)-24(r)-24(hea. CRP concentr)-33(a)15(t)-32(ion w)-12(as ut)-32(i)]TJ 0 Tw (-)Tj 0.023 Tw T* [(l)-31(ized as an)]TJ /Span<>> BDC ( )Tj EMC [(indica)15(t)17(or of)]TJ /Span<>> BDC ( )Tj EMC [(in\265)-16(amma)15(t)-32(ion, which fr)-23.9(equentl)35(y )]TJ 0 Tw T* [(ser)-32(ves as an)]TJ /Span<>> BDC ( )Tj EMC [(indir)-23.8(ec)-16(t cause of)]TJ /Span<>> BDC ( )Tj EMC (hypoalbuminemia [5].)Tj -0.046 Tw T* [(It w)-12(as obser)-32(ved t)-13(ha)15.1(t t)-12.9(he)]TJ /Span<>> BDC ( )Tj EMC (use of)Tj /Span<>> BDC ( )Tj EMC [(t)-12.9(he NUS r)-24(esul)56(ted in a)]TJ /Span<>> BDC ( )Tj EMC (de)Tj 0 Tw (-)Tj 0.101 Tw T* [(cr)-24(ease in t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(oper)-33(a)15(t)-32(i)-16(ve t)-32(ime, post-oper)-33(a)15(t)-32(i)-16(ve dr)-33(aina)-16.9(ge )]TJ 0.053 Tw T* [(vol)35(ume )0.5(and )0.5(over)-33(all )0.5(hospi)-23.9(t)15(al )0.5(st)15(a)15(y. )0.5(All )0.5(t)-13(hese )0.5(dif)-55.9(fer)-24(ences )]TJ 0.074 Tw T* [(wer)-24(e )0.5(st)15(a)15(t)-32(ist)-32(icall)35.1(y signi\251cant be)-12(t)-32(ween )0.5(t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(t)-32(w)-14(o )0.5(gr)-32(oups. )]TJ 0.006 Tw T* [(It )0.5(w)-12(as also )0.5(no)17(ted t)-12.9(ha)15(t t)-13(her)-23.9(e is )0.5(a)]TJ /Span<>> BDC ( )Tj EMC [(signi\251cant )0.5(decr)-23.9(ease in )]TJ 0.042 Tw T* [(albumin levels on post-oper)-33(a)15(t)-32(i)-16(ve d)42(a)15(y)-13(s 1, 2, 3 in t)-12.9(he)]TJ /Span<>> BDC ( )Tj EMC (CH )Tj 0 Tw T* [(gr)-32(oup com)10(p)32(ar)-23.9(ed t)17(o)]TJ /Span<>> BDC ( )Tj EMC [(t)-13(he NUS gr)-31.9(oup [5].)]TJ 0.021 Tw T* [(In summar)-24(y, t)-12.9(he)]TJ /Span<>> BDC ( )Tj EMC (NUS is a)Tj /Span<>> BDC ( )Tj EMC [(helpful t)17(o)-16(ol for col)30(on sur)-32(ger)-24(y )]TJ 0.003 Tw T* [(because )0.5(i)-23.9(t )0.5(mak)10(es )0.5(sur)-32(gical )0.5(p)25(r)-32(o)-15.9(cedur)-24(es )0.5(easier, )0.6(cuts )0.5(d)-16(o)-14(wn )]TJ -0.047 Tw T* [(on oper)-33(a)15(t)-32(ing t)-31.9(imes, bl)30(o)-16(od, and l)35(ym)10(pha)15(t)-32(ic l)30.1(osses, and en)]TJ 0 Tw (-)Tj 0.084 Tw T* [(ables )0.5(adequa)15.1(te )0.5(p)25(r)-32(o)17(tein )0.5(st)17(or)-33(a)-17(ge )0.6(maintenance. )0.5(P)40(a)15(t)-32(ients )]TJ 0.028 Tw T* [(r)-24(ecover mor)-24(e quickl)35.1(y as a)]TJ /Span<>> BDC ( )Tj EMC [(r)-24(esul)56(t, and com)10(pl)-31(ica)15(t)-32(ions ar)-23.9(e )]TJ 0 Tw T* (less common [5].)Tj 0.194 Tw T* [(Ano)17(t)-13(her )0.6(simil)-16(ar )0.5(stud)17(y )0.6(w)-12(as )0.5(conduc)-16(ted )0.5(b)12(y )0.5(R)-24(imond)42(a )0.5(e)-11.9(t )]TJ 0.153 Tw T* [(al., in It)15(al)35(y in 2009. T)47(his w)-12(as a)]TJ /Span<>> BDC ( )Tj EMC [(p)25(r)-32(ospec)-15.9(t)-32(i)-16(ve r)-33(and)-16(om)]TJ 0 Tw (-)Tj 0.095 Tw T* [(ized contr)-32(olled d)-16(ouble-bl)-30.9(ind stud)17(y wi)-24(t)-13(h a)]TJ /Span<>> BDC ( )Tj EMC [(sam)10(ple size )]TJ -0.021 Tw T* (of)Tj /Span<>> BDC ( )Tj EMC [(140 p)32(a)15(t)-32(ients \(70 in ea)-17(ch gr)-32(oup\). It incl)35.1(uded p)32(a)15(t)-32(ients )]TJ 0.325 Tw T* [(under)-32(going l)-16(ap)32(ar)-32(oscopic r)-37(ight hemicolec)-15.9(t)17(omy \(RH\), )]TJ 0.094 Tw T* [(lef)-28(t hemicolec)-16(t)17(omy \(LH\), and anter)-37(ior r)-24(esec)-16(t)-32(ion \(AR\). )]TJ 0.176 Tw T* [(T)47(he)]TJ /Span<>> BDC ( )Tj EMC [(com)10(p)32(ar)-36.9(ison w)-12(as be)-12(t)-32(ween t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(ul)56.1(tr)-33(asonicall)35(y a)-17(c)-16(t)-32(i)]TJ 0 Tw (-)Tj 0.062 Tw T* [(v)-15(a)15(ted scalpel )0.5(ver)-10(sus t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(R)-9.9(adiofr)-24(equency )0.5(scalpel vessel )]TJ 0.008 Tw T* [(seal)-31(ing sy)-13(stem. T)47(he)]TJ /Span<>> BDC ( )Tj EMC [(p)25(r)-37(imar)-23.9(y end point of)]TJ /Span<>> BDC ( )Tj EMC [(t)-13(he stud)17.1(y w)-12(as )]TJ 0.11 Tw T* [(intr)-33(aoper)-32.9(a)15(t)-32(i)-16(ve r)-23.9(educ)-16(t)-32(ion of)]TJ /Span<>> BDC ( )Tj EMC [(bl)30(o)-15.9(od l)30(oss. T)47(he)]TJ /Span<>> BDC ( )Tj EMC [(second)42(ar)-23.9(y )]TJ 0.014 Tw T* [(end )0.5(points )0.5(wer)-23.9(e )0.5(intr)-33(a )0.5(and )0.5(post)17(oper)-32.9(a)15(t)-32(i)-16(ve )0.5(mor)-23.9(bidi)-24(t)-10(y )0.5(and )]TJ 0 Tw T* [(oper)-33(a)15(t)-32(i)-15.9(ve t)-32(ime [6].)]TJ 0.265 Tw T* [(T)47(he )0.5(p)25(r)-32(o)-16(cedur)-23.9(es )0.5(per)-24(for)-16(med )0.5(wer)-23.9(e )0.5(st)15(and)42(ar)-24(dized )0.5(befor)-23.9(e )]TJ 0.492 Tw T* [(st)15(ar)-22(t)-31.9(ing t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(p)25(r)-32(o)17(t)17(o)-16(col. T)60(w)-14(o e)-18(xper)-37(ienced sur)-31.9(geons, )]TJ 0.153 Tw 23.244 64.543 Td [(ea)-17(ch wi)-24(t)-13(h e)-18(xper)-36.9(ience of)]TJ /Span<>> BDC ( )Tj EMC [(mor)-23.9(e t)-12.9(han 400 l)-16(ap)32(ar)-32(oscopic )]TJ 0.398 Tw T* [(col)30(or)-24(ec)-16(t)15.1(al sur)-31.9(ger)-37(ies, per)-24(for)-15.9(med t)-12.9(he)]TJ /Span<>> BDC ( )Tj EMC [(p)25(r)-32(o)-16(cedur)-24(es for )]TJ 0 Tw T* [(t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(stud)17.1(y)]TJ /Span<>> BDC ( )Tj EMC ([6].)Tj -0.059 Tw T* [(T)47(he )0.5(over)-33(all )0.5(intr)-32.9(aoper)-33(a)15(t)-32(i)-16(ve )0.5(bl)30(o)-15.9(od l)30(oss )0.5(and )0.5(oper)-32.9(a)15(t)-32(i)-16(ve )0.5(t)-32(ime )]TJ 0.05 Tw T* [(wer)-24(e )0.6(simil)-16(ar )0.6(in )0.6(t)-13(he)]TJ /Span<>> BDC ( )Tj EMC 7.903 0 Td [(t)-32(w)-14(o )0.6(gr)-32(oups. )0.6(T)47(he)]TJ /Span<>> BDC ( )Tj EMC 6.827 0 Td [(over)-33(all )0.6(post)17(oper)-32.9(a)]TJ 0 Tw (-)Tj -0.033 Tw -14.73 -1.218 Td [(t)-32(i)-16(ve com)10(pl)-31(ica)15(t)-32(ions r)-33(a)15(te w)-12(as 10.7%, which w)-12(as simil)-16(ar in )]TJ -0.018 Tw 0 -1.218 TD [(t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(t)-32(w)-14(o gr)-32(oups. T)47(his stud)17(y concl)35(uded t)-13(ha)15(t t)-12.9(her)-24(e w)-11.9(as no )]TJ 0.004 Tw 0 -1.218 TD [(signi\251cant ad)-17(v)-15(ant)15.1(a)-17(ge of)]TJ /Span<>> BDC ( )Tj EMC [(t)-13(he use of)]TJ /Span<>> BDC ( )Tj EMC [(t)-12.9(he R)-9.9(adiofr)-24(equency )]TJ -0.001 Tw T* [(scalpel dev)-16(ice when com)10(p)32(ar)-24(ed wi)-23.9(t)-13(h t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(ul)56(tr)-33(asonic scal)]TJ 0 Tw (-)Tj T* [(pel dev)-15.9(ice in l)-16(ap)32(ar)-32(oscopic col)30.1(or)-24(ec)-16(t)15.1(al sur)-32(ger)-23.9(y [6].)]TJ 0.213 Tw T* [(S)-16(ince t)-12.9(he)]TJ /Span<>> BDC ( )Tj EMC [(t)-32(w)-14(o dev)-16(ices have dif)-56(fer)-23.9(ent fea)15(tur)-23.9(es, t)-13(heir )]TJ 0.209 Tw T* [(r)-24(esembl)-15.9(ance d)-16(oes no)17(t af)-56(fec)-15.9(t t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(equi)-15.9(v)-15(alency of)]TJ /Span<>> BDC ( )Tj EMC [(t)-13(he )]TJ 0.076 Tw 0 -1.218 TD [(r)-24(esul)56.1(ts. While R)-10(adiofr)-23.9(equency scalpel has super)-37(ior he)]TJ 0 Tw (-)Tj 0.109 Tw 0 -1.218 TD [(most)15(a)15(t)-32(ic po)-14(wer, ul)56(tr)-32.9(asonic scalpel helps wi)-24(t)-13(h t)-12.9(he)]TJ /Span<>> BDC ( )Tj EMC (dis)Tj 0 Tw (-)Tj 0.097 Tw 0 -1.218 TD [(sec)-16(t)-32(ion phase. T)47(he)]TJ /Span<>> BDC ( )Tj EMC (choice of)Tj /Span<>> BDC ( )Tj EMC [(ener)-32(g)16(y dev)-16(ice should be )]TJ 0 Tw T* [(a)-17(ccor)-24(ding t)17.1(o)]TJ /Span<>> BDC ( )Tj EMC [(indi)-16(v)-16(idual p)25.1(r)-24(efer)-23.9(ence [6].)]TJ 0.204 Tw T* [(R)13(ecentl)35(y, a)]TJ /Span<>> BDC ( )Tj EMC [(simil)-16(ar stud)17(y w)-11.9(as conduc)-15.9(ted in a)]TJ /Span<>> BDC ( )Tj EMC [(ter)-21.9(t)-32(ia)]TJ 0 Tw (-)Tj 0.143 Tw T* [(r)-24(y )0.5(hospi)-24(t)15(al )0.5(in India b)12(y )0.5(K)-16(al)-16(ar)-37(i )0.5(e)-12(t )0.5(al. T)47(his )0.5(stud)17(y )0.5(aimed )]TJ 0.006 Tw T* [(t)17(o)]TJ /Span<>> BDC ( )Tj EMC [(com)10(p)32(ar)-24(e t)-13(he)]TJ /Span<>> BDC ( )Tj EMC (use of)Tj /Span<>> BDC ( )Tj EMC [(bipol)-16(ar elec)-16(tr)-32(o)-16(cauter)-23.9(y and ul)56(tr)-33(a)]TJ 0 Tw (-)Tj 0.032 Tw T* [(sonic scalpels in col)30(or)-24(ec)-15.9(t)15(al sur)-32(ger)-37(ies. In t)-13(his stud)17.1(y p)32(a)]TJ 0 Tw (-)Tj -0.071 Tw T* [(t)-32(ients wi)-24(t)-13(h p)25(r)-32(oven col)30(or)-23.9(ec)-16(t)15(al mal)-30.9(ignancy of)]TJ /Span<>> BDC ( )Tj EMC [(st)15(a)-17(ges I and )]TJ 0.019 Tw T* [(II wer)-23.9(e incl)35(uded. 50 p)32(a)15(t)-32(ients wer)-24(e di)-16(v)-16(ided equall)35(y int)17(o )]TJ 0.108 Tw T* [(t)-32(w)-14(o gr)-32(oups b)12(y bl)30(o)-16(ck r)-33(and)-16(omiza)15(t)-31.9(ion, and bipol)-16(ar elec)]TJ 0 Tw (-)Tj 0.052 Tw T* [(tr)-32(o)-16(cauter)-23.9(y w)-12(as used in one gr)-32(oup, and ul)56(tr)-32.9(asonic scal)]TJ 0 Tw (-)Tj T* [(pel w)-11.9(as used in t)-12.9(he)]TJ /Span<>> BDC ( )Tj EMC [(second gr)-32(oup dur)-36.9(ing sur)-32(ger)-23.9(y)]TJ /Span<>> BDC ( )Tj EMC ([7].)Tj 0.262 Tw T* [(Sur)-32(gical p)25(r)-32(o)-16(cedur)-23.9(es per)-24(for)-16(med incl)35(uded RH, LH, AR, )]TJ 0.127 Tw T* [(and abd)-16(ominoper)-37(ineal r)-23.9(esec)-16(t)-32(ion \(APR\) based on si)-24(te, )]TJ 0.224 Tw T* [(e)-18(xtent, and st)15(a)-16.9(ge of)]TJ /Span<>> BDC ( )Tj EMC [(t)-12.9(he tumour. T)47(he)]TJ /Span<>> BDC ( )Tj EMC [(p)32(a)15(t)-32(ients wer)-23.9(e )]TJ 0.09 Tw T* [(foll)30(o)-14(wed up a)15(t r)-24(egul)-15.9(ar inter)-31.9(v)-15(als of)]TJ /Span<>> BDC ( )Tj EMC [(t)-13(hr)-23.9(ee mont)-13(hs. T)47(his )]TJ -0.008 Tw T* [(cont)-32(inued t)17(o)]TJ /Span<>> BDC ( )Tj EMC [(t)-32(w)-13.9(o year)-10(s t)17(o)]TJ /Span<>> BDC ( )Tj EMC [(check for any r)-23.9(ecur)-24(r)-24(ence and )]TJ 0 Tw T* [(st)17(oma com)10(pl)-30.9(ica)15(t)-32(ions [7].)]TJ 0.04 Tw T* [(T)47(he p)32(ar)-33(ame)-12(ter)-10(s studied wer)-24(e t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(mean oper)-33(a)15(t)-32(i)-16(ve t)-32(ime, )]TJ 0.241 Tw T* [(bl)30(o)-16(od l)30(oss, and hospi)-24(t)15(al st)15(a)15(y. T)47(he)]TJ /Span<>> BDC ( )Tj EMC [(ul)56(tr)-33(asonic scalpel )]TJ 0.219 Tw T* [(gr)-32(oup had )0.5(a)]TJ /Span<>> BDC ( )Tj EMC [(l)30(o)-14(wer )0.5(mean )0.5(oper)-33(a)15(t)-32(ing t)-31.9(ime, which )0.5(w)-12(as )]TJ 0.045 Tw T* [(st)15(a)15(t)-32(ist)-31.9(icall)35(y signi\251cant. T)47(he)]TJ /Span<>> BDC ( )Tj EMC [(mean bl)30(o)-16(od l)30(oss in t)-13(he)]TJ /Span<>> BDC ( )Tj EMC (ul)Tj 0 Tw (-)Tj 0.146 Tw T* [(tr)-33(asonic scalpel gr)-32(oup w)-12(as st)15(a)15(t)-32(ist)-31.9(icall)35(y l)30(o)-14(wer t)-12.9(han in )]TJ 0.038 Tw T* [(t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(elec)-16(tr)-32(o)-16(cauter)-23.9(y gr)-32(oup. T)47(he)]TJ /Span<>> BDC ( )Tj EMC [(hospi)-24(t)15.1(al st)15(a)15(y w)-11.9(as l)30(onger )]TJ 0.124 Tw T* [(in t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(elec)-16(tr)-32(o)-16(cauter)-23.9(y gr)-32(oup and w)-11.9(as st)15(a)15(t)-32(ist)-32(icall)35.1(y sig)]TJ 0 Tw (-)Tj T* (ni\251cant [7].)Tj 0.3 Tw T* [(T)47(his stud)17.1(y concl)35.1(uded t)-13(ha)15(t t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(ul)56(tr)-33(asonic scalpel is )]TJ 0.358 Tw T* (an)Tj /Span<>> BDC ( )Tj EMC [(inv)-15(al)35(uable instr)-21.9(ument in col)30(or)-24(ec)-16(t)15(al sur)-32(ger)-23.9(y. In )]TJ 0.049 Tw T* [(ter)-16(ms of)]TJ /Span<>> BDC ( )Tj EMC [(oper)-32.9(a)15(t)-32(i)-16(ve t)-32(ime, bl)30(o)-16(od l)30(oss, and leng)17(t)-13(h of)]TJ /Span<>> BDC ( )Tj EMC (hos)Tj 0 Tw (-)Tj 0.025 Tw T* [(pi)-24(t)15(al st)15.1(a)15(y, t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(ul)56(tr)-33(asonic scalpel per)-24(for)-16(med be)-12(t)-29.9(ter t)-13(han )]TJ 0.318 Tw T* [(t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(bipol)-16(ar elec)-15.9(tr)-32(o)-16(cauter)-24(y dur)-36.9(ing col)30(or)-23.9(ec)-16(t)15(al cancer )]TJ 0 Tw T* [(sur)-32(ger)-36.9(ies.)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 275.0305 152.4638 Tm (CONCLUSION)Tj 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0 Tc 0.24 Tw 10 0 0 10 274.9606 128.1078 Tm [(T)47(her)-24(e is no st)15(a)15(t)-32(ist)-32(ical signi\251cance in t)-12.9(he)]TJ /Span<>> BDC ( )Tj EMC (outcomes )Tj 0.132 Tw T* [(be)-12(t)-32(ween t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(t)-32(w)-14(o gr)-32(oups. Ul)56(tr)-32.9(asonicscalpel as well as )]TJ 0.094 Tw T* [(elec)-16(tr)-31.9(o)-16(cauter)-24(y ar)-24(e v)-14.9(al)35(uable t)17(o)-16(ols in col)30(or)-24(ec)-15.9(t)15(al sur)-32(ger)]TJ 0 Tw 21.758 0 Td (-)Tj 0.106 Tw -21.758 -1.218 Td [(ies wi)-23.9(t)-13(h r)-24(espec)-15.9(t t)17(o)]TJ /Span<>> BDC ( )Tj EMC [(t)-32(issue dissec)-16(t)-32(ion and haemost)15.1(asis )]TJ 0.121 Tw T* [(and ar)-24(e indispensable t)17(o)-15.9(ols in t)-12.9(he)]TJ /Span<>> BDC ( )Tj EMC [(oper)-33(a)15(t)-32(ing t)-13(hea)15(tr)-23.9(e. )]TJ 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0 Tw 7.5 0 0 7.5 42.5197 42.7216 Tm [(\034\201\025\b\222\016\017)-9.9(\026\021\r\215\025\016 \025\211\215\025\212\016\215\026\201\025\r\025\016\ \215\001\235\t\205\211\001\026)11(\016\t\214\215\025\016 \021\b\b)-10(\t\016\211\025\r\001\215\021\016 )]TJ 0 -1 TD [(\242\215\016\201\202)10(\016\026\021\f\016\b\017\021 \200\b)-10(\026\201\025\207\b)-10(\026\r \r\022\017)10(\025\t\025\201\016\017)-10(\026)11(\001\t\214\215\025\207 \021\201\200\201\202\021\021)]TJ 41.119 1 Td [(A Pr)20(ospectiv)12(e Single Centr)31(e Obser)-20.9(v)10(ational Study )]TJ 3.383 -1 Td [(on\022Ener)31.1(gy\022De)11(vices in Color)31(ectal Sur)31(ger)-31(y)]TJ -44.502 96.622 Td [(\036\033\030\031\030\217\n)-20.9(\035\210\217\241\003 \013\032)50(\n)42(\032\210\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj /T1_3 1 Tf 25 0 0 25 503.8146 56.0378 Tm (111)Tj ET endstream endobj 1521 0 obj <>/ExtGState<>/Font<>/ProcSet[/PDF/Text]/Properties<>/Shading<>/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1522 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1523 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1524 0 obj <>/Font<>/ProcSet[/PDF/Text/ImageC]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1525 0 obj <>/Font<>/ProcSet[/PDF/Text/ImageC]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1632 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.094 Tw 10 0 0 10 70.8661 529.9819 Tm [(S)15(tudies conduc)-16(ted b)12(y K)-16(al)-16(ar)-37(i e)-12(t al. and R)-24(imond)42(a e)-12(t al. )]TJ 0.085 Tw 0 -1.218 TD [(also )0.5(incl)35(uded t)-13(he)]TJ /Span<>> BDC ( )Tj EMC 7.359 0 Td [(same )0.5(r)-33(ange of)]TJ /Span<>> BDC ( )Tj EMC 6.105 0 Td [(p)25(r)-32(o)-16(cedur)-23.9(es. In )0.5(K)-16(al)-16(ar)-37(i )]TJ 0.066 Tw -13.463 -1.218 Td [(e)-12(t al., AR w)-12(as t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(most common p)25(r)-32(o)-16(cedur)-23.9(e per)-23.9(for)-16(med, )]TJ 0.059 Tw T* [(which is l)-30.9(ik)10(e our stud)17(y [5,7]. S)-16(ist)15(a e)-12(t al. incl)35(uded onl)35(y )]TJ 0.118 Tw T* [(p)32(a)15(t)-32(ients under)-32(going RH as t)-12.9(he)]TJ /Span<>> BDC ( )Tj EMC [(sur)-31.9(gical steps all)30(o)-14(wed )]TJ 0.418 Tw T* [(com)10(p)32(ar)-37(ison be)-12(t)-32(ween t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(ener)-32(g)16(y dev)-16(ices in ter)-16(ms )]TJ 0.044 Tw T* (of)Tj /Span<>> BDC ( )Tj EMC [(t)-13(heir abil)-31(i)-24(t)-10(y t)17(o)]TJ /Span<>> BDC ( )Tj EMC [(cut, coa)-17(gul)-16(a)15(t)-32(ion and speed of)]TJ /Span<>> BDC ( )Tj EMC [(t)-32(issue )]TJ 0 Tw T* [(dissec)-16(t)-31.9(ion [5].)]TJ 0.146 Tw T* [(In our stud)17.1(y t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(sur)-32(gical p)25(r)-32(o)-16(cedur)-24(es wer)-24(e per)-24(for)-16(med )]TJ 0.168 Tw T* [(b)12(y mul)56(t)-32(iple sur)-32(geons wi)-24(t)-12.9(h dif)-55.9(fer)-24(ent levels of)]TJ /Span<>> BDC ( )Tj EMC [(e)-18(xper)-37(i)]TJ 0 Tw (-)Tj 0.01 Tw T* [(ence. In studies conduc)-15.9(ted b)12(y S)-16(ist)15(a e)-12(t al. and R)-24(imond)42(a )]TJ 0.133 Tw T* [(e)-12(t )0.5(al., )0.5(t)-13(he)]TJ /Span<>> BDC ( )Tj EMC 4.481 0 Td [(sur)-32(gical )0.6(p)25(r)-32(o)-16(cedur)-24(es )0.5(wer)-23.9(e st)15.1(and)42(ar)-24(dized )0.5(and )]TJ 0 Tw -4.481 -1.218 Td [(per)-24(for)-15.9(med b)12(y designa)15(ted sur)-31.9(geons [5,6].)]TJ -0.005 Tw T* [(T)47(he stud)17.1(y b)12(y K)-15.9(al)-16(ar)-37(i e)-12(t al. incl)35(uded p)32(a)15(t)-32(ients wi)-24(t)-13(h p)25(r)-32(oven )]TJ 0.099 Tw T* [(mal)-31(ignancy of)]TJ /Span<>> BDC ( )Tj EMC [(t)-13(he col)30(on and r)-24(ec)-16(tum, wher)-23.9(eas S)-16(ist)15.1(a el )]TJ 0.092 Tw T* [(a)15(t )0.5(incl)35(uded )0.5(p)32(a)15(t)-32(ients )0.6(wi)-24(t)-13(h )0.5(t)-13(he)]TJ /Span<>> BDC ( )Tj EMC 12.342 0 Td [(r)-37(ight )0.5(col)30.1(on mal)-30.9(ignancy. )]TJ 0.18 Tw 10.902 18.267 Td [(T)47(he)]TJ /Span<>> BDC ( )Tj EMC [(sur)-31.9(gical p)25(r)-32(o)-15.9(cedur)-24(e w)-12(as per)-24(for)-15.9(med in a)-17(ccor)-24(d)42(ance )]TJ 0.05 Tw T* [(wi)-24(t)-13(h )0.5(oncol)30.1(o)-16(gical )0.5(p)25(r)-37(inc)-24(iples. )0.6(T)47(his )0.5(maint)15(ained )0.5(unifor)-15.9(mi)]TJ 0 Tw (-)Tj 0.025 Tw T* [(t)-10(y )0.6(in )0.5(t)-13(he)]TJ /Span<>> BDC ( )Tj EMC 3.728 0 Td [(technique )0.6(of)]TJ /Span<>> BDC ( )Tj EMC 5.369 0 Td [(t)-13(he )0.6(p)25(r)-32(o)-16(cedur)-24(e. )0.6(K)-16(al)-16(ar)-37(i )0.6(e)-12(t )0.5(al., )0.6(also )]TJ 0.036 Tw -9.097 -1.218 Td [(incl)35(uded a)]TJ /Span<>> BDC ( )Tj EMC [(t)-32(w)-14(o-year foll)30.1(o)-14(w-up per)-37(iod t)17(o)]TJ /Span<>> BDC ( )Tj EMC [(l)30(o)-16(ok for r)-24(ecur)]TJ 0 Tw 21.758 0 Td (-)Tj 0.001 Tw -21.758 -1.218 Td [(r)-24(ence. 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Bl)30(o)-16(od l)30(oss w)-11.9(as no)17(t consider)-24(ed in )]TJ 0 Tw T* [(t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(stud)17.1(y b)12(y S)-16(ist)15(a e)-11.9(t al.)]TJ 0.019 Tw T* [(A stud)17(y conduc)-16(ted b)12(y S)-16(ist)15.1(a e)-12(t al., in It)15(al)35(y in 2013, wi)-24(t)-13(h )]TJ 0.214 Tw T* (a)Tj /Span<>> BDC ( )Tj EMC [(sam)10(ple size of)]TJ /Span<>> BDC ( )Tj EMC [(211 w)-12(as a)]TJ /Span<>> BDC ( )Tj EMC [(p)25(r)-32(ospec)-15.9(t)-32(i)-16(ve r)-32.9(and)-16(omized )]TJ -0.032 Tw T* [(contr)-32(olled d)-16(ouble-bl)-31(ind stud)17(y. P)40(a)15(t)-32(ients who under)-38(went )]TJ T* [(hemicolec)-16(t)17.1(omy, open )0.5(sur)-32(ger)-24(y )0.5(for cancer )0.5(of)]TJ /Span<>> BDC ( )Tj EMC [(t)-13(he )0.5(r)-37(ight )0.5(co)]TJ 0 Tw (-)Tj -0.014 Tw T* [(l)30(on \(car)-31.9(c)-24(inomas of)]TJ /Span<>> BDC ( )Tj EMC [(t)-13(he cecum, ascending col)30(on, hep)32(a)15(t)-32(ic )]TJ -0.009 Tw T* [(\265e)-18(xur)-23.9(e or tr)-33(ansver)-9.9(se col)30(on\) wer)-24(e incl)35.1(uded in t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(stud)17(y. )]TJ ET q 70.866 90.17 221.102 234.607 re W n q /GS0 gs 221.1023611 0 0 234.6077385 70.866163 90.1700996 cm /Im0 Do Q Q BT 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0 Tw 9 0 0 9 70.8661 79.3701 Tm [(F)-16(igure 3.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf [( Bo)14(x plo)13(t for drain output betw)12.3(een the)]TJ /Span<>> BDC ( )Tj EMC [(tw)12(o g)14(roups. )]TJ ET q /GS0 gs 221.102346 0 0 230.0057967 303.3071019 100.9700888 cm /Im1 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf -0.04 Tw 9 0 0 9 303.3071 90.1701 Tm 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235.5256 705.1617 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 280.8799 725.981 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 326.2343 725.981 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 326.2343 705.1617 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 374.4232 725.981 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 422.6122 725.981 cm 0 0 m 51.024 0 l S Q q 1 0 0 1 422.6122 705.1617 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 473.6358 725.981 cm 0 0 m 51.274 0 l S Q q 1 0 0 1 524.6594 705.1617 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 70.8661 704.9117 cm 0 0 m 68.281 0 l S Q q 1 0 0 1 71.1161 684.1005 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 139.1476 704.9117 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 139.1476 684.1005 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 187.3366 704.9117 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 235.5256 704.9117 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 235.5256 684.1005 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 280.8799 704.9117 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 326.2343 704.9117 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 326.2343 684.1005 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 374.4232 704.9117 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639.8666 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 187.3366 619.0553 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 235.5256 639.8666 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 235.5256 619.0553 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 280.8799 639.8666 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 280.8799 619.0553 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 326.2343 639.8666 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 326.2343 619.0553 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 374.4232 639.8666 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 374.4232 619.0553 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 422.6122 639.8666 cm 0 0 m 51.024 0 l S Q q 1 0 0 1 422.6122 619.0553 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 473.6358 639.8666 cm 0 0 m 51.274 0 l S Q q 1 0 0 1 473.6358 619.0553 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 524.6594 619.0553 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 70.8661 618.8053 cm 0 0 m 68.281 0 l S Q q 1 0 0 1 71.1161 607.5941 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 139.1476 618.8053 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 139.1476 607.5941 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 187.3366 618.8053 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 187.3366 607.5941 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 235.5256 618.8053 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 235.5256 607.5941 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 280.8799 618.8053 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 280.8799 607.5941 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 326.2343 618.8053 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 326.2343 607.5941 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 374.4232 618.8053 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 374.4232 607.5941 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 422.6122 618.8053 cm 0 0 m 51.024 0 l S Q q 1 0 0 1 422.6122 607.5941 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 473.6358 618.8053 cm 0 0 m 51.274 0 l S Q q 1 0 0 1 473.6358 607.5941 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 607.5941 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 607.3441 cm 0 0 m 68.281 0 l S Q q 1 0 0 1 71.1161 576.9327 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 139.1476 607.3441 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 139.1476 576.9327 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 187.3366 607.3441 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 187.3366 576.9327 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 235.5256 607.3441 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 235.5256 576.9327 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 280.8799 607.3441 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 280.8799 576.9327 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 326.2343 607.3441 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 326.2343 576.9327 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 374.4232 607.3441 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 374.4232 576.9327 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 422.6122 607.3441 cm 0 0 m 51.024 0 l S Q q 1 0 0 1 422.6122 576.9327 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 473.6358 607.3441 cm 0 0 m 51.274 0 l S Q q 1 0 0 1 473.6358 576.9327 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 524.6594 576.9327 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 70.8661 576.6827 cm 0 0 m 68.281 0 l S Q q 1 0 0 1 71.1161 555.8715 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 139.1476 576.6827 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 139.1476 555.8715 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 187.3366 576.6827 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 187.3366 555.8715 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 235.5256 576.6827 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 235.5256 555.8715 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 280.8799 576.6827 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 280.8799 555.8715 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 326.2343 576.6827 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 326.2343 555.8715 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 374.4232 576.6827 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 374.4232 555.8715 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 422.6122 576.6827 cm 0 0 m 51.024 0 l S Q q 1 0 0 1 422.6122 555.8715 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 473.6358 576.6827 cm 0 0 m 51.274 0 l S Q q 1 0 0 1 473.6358 555.8715 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 524.6594 555.8715 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 70.8661 555.6215 cm 0 0 m 68.281 0 l S Q q 1 0 0 1 139.1476 555.6215 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 187.3366 555.6215 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 235.5256 555.6215 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 280.8799 555.6215 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 326.2343 555.6215 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 374.4232 555.6215 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 422.6122 555.6215 cm 0 0 m 51.024 0 l S Q q 1 0 0 1 473.6358 555.6215 cm 0 0 m 51.274 0 l S Q BT /GS1 gs /T1_1 1 Tf 8 0 0 8 95.5961 712.5464 Tm (Study)Tj 9.017 0.6 Td (Kalari et al.)Tj 1.706 -1.2 Td (RCT)Tj 10.202 1.2 Td (Sista et al.)Tj 1.491 -1.2 Td (RCT)Tj 9.38 1.2 Td (Rimonda et al.)Tj 2.312 -1.2 Td (RCT)Tj 10.294 0.6 Td (Current study)Tj /T1_0 1 Tf -47.109 -2.033 Td (Study setting / )Tj 0 -1.2 TD (Study period)Tj 12.049 1.2 Td (Pune 2022)Tj 11.754 0 Td (Italy 2013)Tj 11.693 0 Td (Italy 2009)Tj 13.465 0 Td (2022)Tj -48.961 -2.633 Td (Sample size)Tj 13.673 0 Td (50)Tj 11.443 0 Td (211)Tj 11.693 0 Td (140)Tj 12.652 0 Td (68)Tj -49.461 -1.433 Td (Procedure)Tj 11.113 0 Td (RH, LH, AR, APR)Tj 14.184 0 Td (RH)Tj 7.475 0 Td (Laparoscopic RH, LH, AR)Tj 14.46 0 Td (RH, LH, AR, SC)Tj -47.232 -1.433 Td (Energy source)Tj 8.743 0 Td (Bipolar \(25\))Tj 6.389 0 Td (Ultrasonic )Tj -0.321 -1.2 Td (scalpel \(25\))Tj 6.161 1.2 Td (NUS \(108\))Tj 5.953 0 Td (CH \(103\))Tj 5.429 0 Td (Ultracision )Tj 1.323 -1.2 Td (\(70\))Tj 5.169 1.2 Td (LigaSure)Tj 0.854 -1.2 Td (\(70\))Tj 5.609 1.2 Td (EC \(31\))Tj 6.324 0 Td (US \(37\))Tj -51.635 -2.633 Td (Operative time )Tj T* (\(minutes\))Tj 8.632 1.2 Td (175.6)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (27.4)Tj 6.422 0 Td (137)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (26.7)Tj 6.244 0 Td (103)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (21)Tj 5.669 0 Td (131)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (27)Tj 5.05 0 Td (114.8)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (47.6)Tj 6.024 0 Td (116.3)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (44.0)Tj 6.201 0 Td (270.8)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (95.5)Tj 6.128 0 Td (280.7)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (101.5 )Tj -50.371 -2.633 Td (Blood loss \(ml\))Tj 8.632 0 Td (271.8)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (80.6)Tj 6.422 0 Td (184)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (68.1)Tj 7.406 0 Td (NA)Tj 5.669 0 Td (NA)Tj 3.889 0 Td (107.9)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (42.0)Tj 6.024 0 Td (111.2)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (51.5)Tj 5.951 0 Td (219.4)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (150.4)Tj 6.378 0 Td (275.4)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (265.4)Tj -50.371 -1.433 Td (Duration )Tj T* (of)Tj /Span<>> BDC ( )Tj EMC (hospital stay )Tj T* (\(days\))Tj 9.132 2.4 Td (12.3)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (2.6)Tj 6.274 0 Td (9.7)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (2.2)Tj 7.375 0 Td (8)Tj 5.419 0 Td (11)Tj 4.567 0 Td (7.4)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (2.2)Tj 6.024 0 Td (6.9)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (3.3)Tj 6.201 0 Td (7.2)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (1.9)Tj 6.378 0 Td (7.6)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (3.1)Tj -51.371 -3.833 Td (Drain output \(ml\))Tj 10.59 0 Td (NA)Tj 6.024 0 Td (NA)Tj 4.009 0 Td (D1:125)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (40)Tj 0.25 -1.2 Td (D2:70)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (30)Tj 5.419 1.2 Td (D1:155)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (50)Tj T* (D2:110)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (35)Tj 7.684 1.2 Td (NA)Tj 6.024 0 Td (NA)Tj 4.243 0 Td (148.7)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (63.9)Tj 7.174 0 Td (149)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (51)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\033\030\031\030\217\n)-20.9(\035\210\217\241\003 \013\032)50(\n)42(\032\210\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj -51.938 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 2)69(4, \023\0224, 202)23(5)]TJ 43.013 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 2)69(4, \023\0224, 202)23(5)]TJ /T1_4 1 Tf 25 0 0 25 19.9277 56.0378 Tm (110)Tj ET endstream endobj 1631 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.283 Tw 10 0 0 10 42.5197 603.0499 Tm [(T)47(he)]TJ /Span<>> BDC ( )Tj EMC [(t)-9.9(ype of)]TJ /Span<>> BDC ( )Tj EMC [(anast)17(omosis per)-24(for)-16(med w)-12(as ei)-24(t)-13(her end )]TJ 0.166 Tw 0 -1.218 TD [(t)17(o)]TJ /Span<>> BDC ( )Tj EMC [(end in 35 \(51.5%\) or side t)17(o)]TJ /Span<>> BDC ( )Tj EMC (side in 33 \(48.5%\). )Tj 0.115 Tw T* [(T)47(he)]TJ /Span<>> BDC ( )Tj EMC [(technique used for anast)17(omosis w)-12(as ei)-23.9(t)-13(her hand-)]TJ 0.132 Tw 0 -1.218 TD [(sewn in 16 \(23.5%\) or st)15(apler in 52 \(76.5%\). Among )]TJ 0.111 Tw 0 -1.218 TD [(t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(l)-15.9(ap)32(ar)-32(oscopic p)25(r)-32(o)-16(cedur)-23.9(es, 28 \(71.8%\) of)]TJ /Span<>> BDC ( )Tj EMC [(t)-13(he anas)]TJ 0 Tw (-)Tj 0.207 Tw 0 -1.218 TD [(t)17(omosis wer)-24(e e)-18(xtr)-32.9(a)-17(cor)-24(por)-24(eal, while 11 \(28.2%\) wer)-23.9(e )]TJ 0.068 Tw 0 -1.218 TD [(intr)-33(a)-17(cor)-23.9(por)-24(eal. S)-16(k)-16(in cl)30(osur)-24(e w)-12(as d)-16(one using st)15(aples in )]TJ 0 Tw 0 -1.218 TD (52 \(76.5%\) of)Tj /Span<>> BDC ( )Tj EMC [(t)-12.9(he sur)-32(ger)-36.9(ies and sutur)-23.9(es in 16 \(23.5%\). )]TJ 0.016 Tw 0 -1.218 TD (A)Tj /Span<>> BDC ( )Tj EMC [(di)-16(ver)-10(sion st)17(oma w)-12(as cr)-24(ea)15(ted in 9 \(13.2%\) of)]TJ /Span<>> BDC ( )Tj EMC [(t)-13(he p)25(r)-32(o)]TJ 0 Tw (-)Tj -0.049 Tw 0 -1.218 TD [(cedur)-24(es, out of)]TJ /Span<>> BDC ( )Tj EMC (which, all of)Tj /Span<>> BDC ( )Tj EMC [(t)-13(hem wer)-24(e l)30.1(o)-16(op ileost)17.1(omies.)]TJ -0.008 Tw T* [(Mal)-31(ignancy of)]TJ /Span<>> BDC ( )Tj EMC [(t)-13(he col)30.1(on and r)-24(ec)-16(tum w)-12(as t)-13(he)]TJ /Span<>> BDC ( )Tj EMC (most com)Tj 0 Tw (-)Tj 0.057 Tw 0 -1.218 TD [(mon indica)15(t)-32(ion for which sur)-32(ger)-24(y w)-12(as per)-23.9(for)-16(med. Onl)35(y )]TJ 0.086 Tw 0 -1.218 TD [(6 \(8.8%\) sur)-32(ger)-36.9(ies wer)-24(e per)-24(for)-16(med for benign p)32(a)15(t)-13(hol)]TJ 0 Tw (-)Tj 0.102 Tw 0 -1.218 TD [(o)-16(g)16(y. T)47(he)]TJ /Span<>> BDC ( )Tj EMC [(most common mal)-31(ignant hist)17.1(op)32(a)15(t)-13(hol)30(o)-16(g)16(y w)-12(as )]TJ 0.033 Tw 0 -1.218 TD [(adeno)-16(car)-32(c)-23.9(inoma, seen in 56 \(82.4%\) cases. Ot)-13(her con)]TJ 0 Tw (-)Tj 0.15 Tw 0 -1.218 TD [(di)-24(t)-32(ions seen wer)-24(e non-Hodgk)-16(ins\246s l)35(ym)10(phoma \(Dif)-56(fuse )]TJ 0 Tw 0 -1.218 TD [(l)-16(ar)-32(ge B-cell l)35.1(ym)10(phoma\) and neur)-31.9(oend)-16(o)-16(cr)-36.9(ine tumor.)]TJ 0.187 Tw 0 -1.218 TD [(T)47(he outcomes )0.5(studied )0.5(wer)-24(e )0.5(t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(dur)-33(a)15(t)-31.9(ion of)]TJ /Span<>> BDC ( )Tj EMC 18.791 0 Td [(t)-13(he )0.5(sur)]TJ 0 Tw 2.968 0 Td (-)Tj 0.017 Tw -21.758 -1.218 Td [(ger)-24(y )0.5(\(minutes\), )0.6(dr)-33(ain )0.5(output )0.5(in )0.5(t)-12.9(he)]TJ /Span<>> BDC ( )Tj EMC 14.418 0 Td [(\251r)-10(st )0.5(48 )0.5(hour)-9.9(s )0.5(\(mL\), )]TJ 0.166 Tw -14.418 -1.218 Td [(dur)-33(a)15(t)-32(ion )0.6(of)]TJ /Span<>> BDC ( )Tj EMC 5.108 0 Td [(hospi)-24(t)15(al )0.6(st)15(a)15(y )0.6(\(d)42(a)15(y)-13(s\) )0.6(and )0.6(dur)-33(a)15(t)-32(ion )0.6(of)]TJ /Span<>> BDC ( )Tj EMC 15.567 0 Td (ICU )Tj 0.19 Tw -20.675 -1.218 Td [(st)15(a)15(y \(d)42(a)15(y)-13(s\) as sho)-14(wn in T)40(able 2. T)47(he)]TJ /Span<>> BDC ( )Tj EMC [(mean dur)-32.9(a)15(t)-32(ion )]TJ 0.182 Tw 23.244 24.356 Td (of)Tj /Span<>> BDC ( )Tj EMC 1.23 0 Td [(sur)-32(ger)-23.9(y, as )0.5(pl)30(o)17(t)-30(ted )0.5(in F)-18.9(igur)-24(e 1, )0.5(t)-13(he)]TJ /Span<>> BDC ( )Tj EMC 15.241 0 Td [(EC )0.5(gr)-32(oup w)-11.9(as )]TJ 0.274 Tw -16.47 -1.218 Td (270.8)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC [(95.5 minutes and in t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(US gr)-32(oup i)-24(t w)-12(as )]TJ 0.014 Tw T* (280.7)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC [(101.5 minutes. F)-19(igur)-23.9(e 2 sho)-13.9(ws t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(mean bl)30(o)-16(od )]TJ -0.025 Tw 0 -1.218 TD [(l)30(oss )0.5(in t)-13(he)]TJ /Span<>> BDC ( )Tj EMC 4.279 0 Td [(EC )0.5(gr)-32(oup w)-12(as )0.5(219.4)]TJ /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC [(150.4 )0.5(mL and )0.5(in t)-13(he)]TJ /Span<>> BDC ( )Tj EMC 16.775 0 Td (US )Tj 0.056 Tw -21.053 -1.218 Td [(gr)-32(oup i)-23.9(t w)-12(as 275.4)]TJ /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC 8.755 0 Td [(265.4 mL. )0.5(T)47(he)]TJ /Span<>> BDC ( )Tj EMC [(mean v)-15(al)35(ue )0.5(of)]TJ /Span<>> BDC ( )Tj EMC [(t)-13(he )]TJ 0.04 Tw -8.755 -1.218 Td [(dr)-33(ain output in t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(\251r)-10(st 48 hour)-10(s w)-12(as 148.1)]TJ /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (63.9 mL )Tj 0.074 Tw 0 -1.218 TD [(in t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(EC gr)-32(oup. In t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(US gr)-32(oup, i)-24(t w)-12(as 149)]TJ /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (51 mL, )Tj -0.035 Tw 0 -1.218 TD [(t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(same has been depic)-16(ted in F)-19(igur)-23.9(e 3. T)47(he)]TJ /Span<>> BDC ( )Tj EMC [(mean dur)-33(a)]TJ 0 Tw (-)Tj 0.01 Tw 0 -1.218 TD [(t)-32(ion of)]TJ /Span<>> BDC ( )Tj EMC [(hospi)-24(t)15(al st)15(a)15(y in t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(EC gr)-32(oup w)-12(as 7.2)]TJ /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC [(1.9 d)42(a)15(y)-13(s )]TJ 0.012 Tw 0 -1.218 TD [(and in t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(US gr)-32(oup i)-24(t w)-12(as 7.6)]TJ /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC [(3.1 d)42(a)15(y)-13(s and t)-13(he)]TJ /Span<>> BDC ( )Tj EMC (same )Tj 0.157 Tw T* [(is ev)-16(ident fr)-31.9(om F)-19(igur)-23.9(e 4. In our stud)17(y, t)-13(her)-24(e w)-12(as no )]TJ 0.294 Tw 0 -1.218 TD [(st)15(a)15(t)-32(ist)-31.9(icall)35(y signi\251cant dif)-55.9(fer)-24(ence be)-12(t)-32(ween t)-12.9(he)]TJ /Span<>> BDC ( )Tj EMC [(t)-32(w)-14(o )]TJ 0 Tw 0 -1.218 TD [(gr)-32(oups wi)-23.9(t)-13(h r)-24(espec)-15.9(t t)17(o)]TJ /Span<>> BDC ( )Tj EMC [(t)-13(he above p)32.1(ar)-33(ame)-12(ter)-9.9(s.)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 275.0305 420.3798 Tm [(DISCUS)21(SION)]TJ 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0 Tc 0.097 Tw 10 0 0 10 274.9606 396.0238 Tm [(T)40(able 3 sho)-14(ws t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(com)10(p)32(ar)-36.9(ison be)-11.9(t)-32(ween our stud)17(y and )]TJ 0.086 Tw T* [(o)17(t)-13(her simil)-16(ar studies car)-24(r)-36.9(ied out a)15(t a)]TJ /Span<>> BDC ( )Tj EMC [(na)15(t)-32(ional and in)]TJ 0 Tw (-)Tj -0.024 Tw T* [(ter)-15(na)15(t)-32(ional level. It depic)-15.9(ts t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(ener)-32(g)16(y dev)-15.9(ices studied, )]TJ 0 Tw T* [(and t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(outcome p)32.1(ar)-33(ame)-11.9(ter)-10(s obser)-32(ved in ea)-16.9(ch gr)-32(oup.)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf -0.027 Tc 0.027 Tw 9 0 0 9 42.5197 730.483 Tm [(T)0.5(a)-35.3(b)-40.7(l)-38.7(e)-27( 2)-34.3(.)]TJ 0 0 0 1 k /GS1 gs /T1_3 1 Tf 0 Tc 0 Tw 3.334 0 Td [( D)-12.1(i)6.6(s)-14.8(t)-9.5(r)-39(i)4.6(b)-1.5(u)-4.8(t)-29.1(i)-1.4(o)-4(n o)4.1(f)]TJ /Span<>> BDC ( )Tj EMC [(o)-3.3(u)-4.8(t)-3.4(c)2.8(o)-4(m)-5.3(e v)6.4(a)-4.2(r)-39(i)1.5(a)-0.9(b)-3.4(le)-22(s a)-5(m)-5.3(o)-4(n)-0.6(g t)-10.6(h)-2.4(e)]TJ /Span<>> BDC ( )Tj EMC [(t)-22.9(w)2.3(o g)-1.5(r)-2(o)-3.4(u)-2.3(p)1.8(s i)3.9(n t)-10.5(h)-2.4(e)]TJ /Span<>> BDC ( )Tj EMC [(s)-14.8(t)-1.1(u)-5.9(d)-7.2(y \()61.8(m)-5.3(e)-7.5(a)-5.1(n)64.8(\))]TJ ET 0 0 0 1 K 0.5 w /GS2 gs q 1 0 0 1 42.5197 725.981 cm 0 0 m 136.313 0 l S Q q 1 0 0 1 42.7697 714.5117 cm 0 0 m 0 11.219 l S Q q 1 0 0 1 178.8327 725.981 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 178.8327 714.7617 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 235.5256 725.981 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 292.2185 725.981 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 292.2185 714.7617 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 348.9114 725.981 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 405.6043 725.981 cm 0 0 m 90.959 0 l S Q q 1 0 0 1 405.6043 714.7617 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 496.313 714.5117 cm 0 0 m 0 11.219 l S Q q 1 0 0 1 42.7697 703.2925 cm 0 0 m 0 11.219 l S Q q 1 0 0 1 178.5827 714.5117 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 178.8327 703.2925 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 235.5256 714.5117 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 235.5256 703.2925 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 292.2185 714.5117 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 292.2185 703.2925 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 348.9114 714.5117 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 348.9114 703.2925 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 405.6043 703.2925 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 496.313 703.2925 cm 0 0 m 0 11.219 l S Q q 1 0 0 1 42.5197 703.0425 cm 0 0 m 136.313 0 l S Q q 1 0 0 1 42.7697 691.8312 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 178.8327 703.0425 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 178.8327 691.8312 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 235.5256 703.0425 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 235.5256 691.8312 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 292.2185 703.0425 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 292.2185 691.8312 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 348.9114 703.0425 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 348.9114 691.8312 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 405.6043 703.0425 cm 0 0 m 90.959 0 l S Q q 1 0 0 1 405.6043 691.8312 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 691.8312 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 691.5812 cm 0 0 m 136.313 0 l S Q q 1 0 0 1 42.7697 680.3699 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 178.8327 691.5812 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 178.8327 680.3699 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 235.5256 691.5812 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 235.5256 680.3699 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 292.2185 691.5812 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 292.2185 680.3699 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 348.9114 691.5812 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 348.9114 680.3699 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 405.6043 691.5812 cm 0 0 m 90.959 0 l S Q q 1 0 0 1 405.6043 680.3699 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 680.3699 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 680.1199 cm 0 0 m 136.313 0 l S Q q 1 0 0 1 42.7697 668.9087 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 178.8327 680.1199 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 178.8327 668.9087 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 235.5256 680.1199 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 235.5256 668.9087 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 292.2185 680.1199 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 292.2185 668.9087 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 348.9114 680.1199 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 348.9114 668.9087 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 405.6043 680.1199 cm 0 0 m 90.959 0 l S Q q 1 0 0 1 405.6043 668.9087 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 668.9087 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 668.6587 cm 0 0 m 136.313 0 l S Q q 1 0 0 1 42.7697 657.4474 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 178.8327 668.6587 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 178.8327 657.4474 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 235.5256 668.6587 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 235.5256 657.4474 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 292.2185 668.6587 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 292.2185 657.4474 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 348.9114 668.6587 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 348.9114 657.4474 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 405.6043 668.6587 cm 0 0 m 90.959 0 l S Q q 1 0 0 1 405.6043 657.4474 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 657.4474 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 657.1974 cm 0 0 m 136.313 0 l S Q q 1 0 0 1 42.7697 645.9861 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 178.8327 657.1974 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 178.8327 645.9861 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 235.5256 657.1974 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 235.5256 645.9861 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 292.2185 657.1974 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 292.2185 645.9861 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 348.9114 657.1974 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 348.9114 645.9861 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 405.6043 657.1974 cm 0 0 m 90.959 0 l S Q q 1 0 0 1 405.6043 645.9861 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 645.9861 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 645.7361 cm 0 0 m 136.313 0 l S Q q 1 0 0 1 42.7697 634.5248 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 178.8327 645.7361 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 178.8327 634.5248 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 235.5256 645.7361 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 235.5256 634.5248 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 292.2185 645.7361 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 292.2185 634.5248 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 348.9114 645.7361 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 348.9114 634.5248 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 405.6043 645.7361 cm 0 0 m 90.959 0 l S Q q 1 0 0 1 405.6043 634.5248 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 634.5248 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 634.2748 cm 0 0 m 136.313 0 l S Q q 1 0 0 1 178.8327 634.2748 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 235.5256 634.2748 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 292.2185 634.2748 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 348.9114 634.2748 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 405.6043 634.2748 cm 0 0 m 90.959 0 l S Q BT /GS1 gs /T1_2 1 Tf 8 0 0 8 95.0895 711.6118 Tm (Variables)Tj 14.488 0.717 Td (Electrocautery)Tj 13.426 0 Td (Ultrasonic Scalpel)Tj 13.382 -0.117 Td (Unpaired t test)Tj 1.653 -1.2 Td (P value)Tj -30.047 -0.117 Td (Mean)Tj 7.654 0 Td (SD)Tj 6.52 0 Td (Mean)Tj 7.654 0 Td (SD)Tj /T1_0 1 Tf -40.914 -1.433 Td (Duration of)Tj /Span<>> BDC ( )Tj EMC (surgery \(minutes\) )Tj 19.049 0 Td (270.8)Tj 7.337 0 Td (95.5)Tj 6.837 0 Td (280.7)Tj 7.087 0 Td (101.5)Tj 9.213 0 Td (0.683)Tj -49.521 -1.433 Td (Intra-operative blood loss \(ml\) )Tj 19.049 0 Td (219.4)Tj 7.087 0 Td (150.4)Tj 7.087 0 Td (275.4)Tj 7.087 0 Td (265.4)Tj 9.213 0 Td (0.301)Tj -49.521 -1.433 Td (Drain output \(ml\) )Tj 19.049 0 Td (148.1)Tj 7.337 0 Td (63.9)Tj 6.837 0 Td (149.0)Tj 7.337 0 Td (51.0)Tj 8.963 0 Td (0.947)Tj -49.521 -1.433 Td (Duration of)Tj /Span<>> BDC ( )Tj EMC (stay \(days\) )Tj 19.549 0 Td (7.2)Tj 7.087 0 Td (1.9)Tj 7.087 0 Td (7.6)Tj 7.087 0 Td (3.1)Tj 8.713 0 Td (0.500)Tj -49.521 -1.433 Td (Duration of)Tj /Span<>> BDC ( )Tj EMC (ICU stay \(days\) )Tj 19.549 0 Td (2.0)Tj 7.087 0 Td (0.0)Tj 7.087 0 Td (3.6)Tj 7.087 0 Td (3.4)Tj 8.713 0 Td (0.681)Tj -49.521 -1.433 Td (Hb change )Tj 19.549 0 Td (.15)Tj 6.837 0 Td (1.33)Tj 7.337 0 Td (.61)Tj 6.837 0 Td (1.45)Tj 8.963 0 Td (0.179)Tj ET q 42.52 100.97 221.102 234.33 re W n q /GS0 gs 221.1023484 0 0 234.3306932 42.5196843 100.9700818 cm /Im0 Do Q Q BT 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.173 Tw 9 0 0 9 42.5197 90.1701 Tm [(F)-16(igure 1)47(.)]TJ 0 0 0 1 k /GS1 gs /T1_3 1 Tf [( Bo)14(x plo)13(t for duration of)]TJ /Span<>> BDC ( )Tj EMC [(surg)12(er)-43(y betw)12(een the)]TJ /Span<>> BDC ( )Tj EMC [(tw)12(o )]TJ 0 Tw 0 -1.2 TD [(g)14(roups. )]TJ ET q /GS0 gs 221.1023829 0 0 237.1686241 274.9606444 100.9700708 cm /Im1 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.301 Tw 9 0 0 9 274.9606 90.1701 Tm [(F)-16(igure 2)16(.)]TJ 0 0 0 1 k /GS1 gs /T1_3 1 Tf [( Bo)14(x plo)13(t for intra-operativ)13(e blood loss betw)12(een )]TJ 0 Tw T* (the)Tj /Span<>> BDC ( )Tj EMC [(tw)12(o g)14.1(roups.)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\034\201\025\b\222\016\017)-9.9(\026\021\r\215\025\016 \025\211\215\025\212\016\215\026\201\025\r\025\016\ \215\001\235\t\205\211\001\026)11(\016\t\214\215\025\016 \021\b\b)-10(\t\016\211\025\r\001\215\021\016 )]TJ 0 -1 TD [(\242\215\016\201\202)10(\016\026\021\f\016\b\017\021 \200\b)-10(\026\201\025\207\b)-10(\026\r \r\022\017)10(\025\t\025\201\016\017)-10(\026)11(\001\t\214\215\025\207 \021\201\200\201\202\021\021)]TJ 41.119 1 Td [(A Pr)20(ospectiv)12(e Single Centr)31(e Obser)-20.9(v)10(ational Study )]TJ 3.383 -1 Td [(on\022Ener)31.1(gy\022De)11(vices in Color)31(ectal Sur)31(ger)-31(y)]TJ -44.502 96.622 Td [(\036\033\030\031\030\217\n)-20.9(\035\210\217\241\003 \013\032)50(\n)42(\032\210\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj /T1_5 1 Tf 25 0 0 25 505.5021 56.0378 Tm (109)Tj ET endstream endobj 1630 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.03 Tw 10 0 0 10 70.8661 444.7359 Tm [(r)-24(ecr)-21.9(ui)-24(ted a)-17(ccor)-24(ding t)17(o)]TJ /Span<>> BDC ( )Tj EMC [(t)-13(he incl)35(usion and e)-18(x)-12.9(cl)35(usion cr)-37(i)]TJ 0 Tw (-)Tj 0.007 Tw 0 -1.218 TD [(ter)-37(ia. A)]TJ /Span<>> BDC ( )Tj EMC [(p)32(ar)-21.9(t)-32(ic)-24(ip)32(ant infor)-16(ma)15(t)-31.9(ion shee)-11.9(t w)-12(as handed over )]TJ -0.039 Tw T* [(and infor)-15.9(med consent w)-12(as t)15.1(ak)10(en. Da)15(t)15(a w)-12(as collec)-15.9(ted us)]TJ 0 Tw (-)Tj T* (ing a)Tj /Span<>> BDC ( )Tj EMC [(p)25(r)-31.9(ofor)-16(ma.)]TJ 0.024 Tw T* [(T)47(his stud)17(y incl)35.1(uded p)32(a)15(t)-32(ients above t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(a)-17(ge of)]TJ /Span<>> BDC ( )Tj EMC 18.58 0 Td [(18 year)-10(s, )]TJ 0.396 Tw -18.58 -1.218 Td [(under)-32(going elec)-15.9(t)-32(i)-16(ve col)30(or)-24(ec)-16(t)15(al sur)-31.9(ger)-24(y for v)-15(ar)-37(ious )]TJ 0.221 Tw T* [(benign and mal)-31(ignant p)32(a)15(t)-13(hol)30.1(o)-16(gies. It incl)35(uded bo)17(t)-13(h )]TJ 0.099 Tw T* (an)Tj /Span<>> BDC ( )Tj EMC [(open and l)-16(ap)32(ar)-32(oscopic app)25(r)-32(oa)-17(ch. Any p)32(a)15(t)-32(ient wi)-24(t)-13(h )]TJ 0 Tw T* [(unsa)15(t)-32(isf)16(a)-16.9(c)-16(t)17(or)-24(y d)42(a)15(t)15(a w)-11.9(as e)-18(x)-13(cl)35(uded fr)-31.9(om t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(stud)17.1(y.)]TJ 0.028 Tw T* [(T)47(he outcomes wer)-23.9(e measur)-23.9(ed in ter)-16(ms of)]TJ /Span<>> BDC ( )Tj EMC [(t)-13(he foll)30(o)-14(wing )]TJ 0 Tw T* [(p)32(ar)-33(ame)-12(ter)-9.9(s)]TJ 0.252 Tw T* (\243)Tj /Span<>> BDC [( )-15( )]TJ EMC 1 0 Td [(Oper)-33(a)15(t)-32(i)-15.9(ve t)-31.9(ime in minutes \(t)-32(ime of)]TJ /Span<>> BDC ( )Tj EMC [(sk)-16(in inc)-24(ision )]TJ 0 Tw T* [(t)17(o)]TJ /Span<>> BDC ( )Tj EMC [(sk)-16(in cl)30.1(osur)-24(e\))]TJ 1.353 Tw -1 -1.218 Td (\243)Tj /Span<>> BDC [( )1086( )]TJ EMC 1 0 Td [(Intr)-33(a-oper)-32.9(a)15(t)-32(i)-16(ve bl)30(o)-15.9(od l)30(oss in mill)-30.9(il)-31(i)-24(ter)-9.9(s )]TJ 0 Tw T* (\(gauze)Tj /Span<>> BDC ( )Tj EMC (+)Tj /Span<>> BDC ( )Tj EMC (mop)Tj /Span<>> BDC ( )Tj EMC (+)Tj /Span<>> BDC ( )Tj EMC [(suc)-15.9(t)-32(ion vol)35.1(ume\))]TJ 0.023 Tw -1 -1.218 Td (\243)Tj /Span<>> BDC [( )-244( )]TJ EMC 1 0 Td [(P)10(ost-oper)-32.9(a)15(t)-32(i)-16(ve dr)-33(ain vol)35.1(ume for t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(\251r)-9.9(st 48 hour)-10(s in )]TJ 0 Tw T* [(mill)-31(il)-30.9(i)-24(ter)-10(s)]TJ 0.237 Tw -1 -1.218 Td (\243)Tj /Span<>> BDC [( )-30( )]TJ EMC 1 0 Td [(Dur)-33(a)15(t)-32(ion of)]TJ /Span<>> BDC ( )Tj EMC [(hospi)-23.9(t)15(al st)15.1(a)14.9(y in d)42(a)15(y)-12.9(s \(d)42(a)15(y of)]TJ /Span<>> BDC ( )Tj EMC [(sur)-32(ger)-23.9(y )]TJ 0 Tw T* [(t)17(o)]TJ /Span<>> BDC ( )Tj EMC [(t)-13(he d)42.1(a)15(y of)]TJ /Span<>> BDC ( )Tj EMC [(dischar)-32(ge\))]TJ 0.244 Tw -1 -1.218 Td [(T)47(he collec)-15.9(ted d)42(a)15(t)15.1(a w)-12(as enter)-24(ed int)17(o an)]TJ /Span<>> BDC ( )Tj EMC [(E)35(x)-13(cel shee)-12(t )]TJ 0.168 Tw T* [(and )0.5(w)-12(as )0.5(anal)35.1(yzed )0.5(using )0.5(SPS)17(S )0.5(ver)-9.9(sion )0.5(23. )0.5(Ca)15(tegor)-37(ical )]TJ 0.184 Tw T* [(d)42(a)15(t)15(a w)-12(as summar)-37(ised b)12(y fr)-23.9(equency and per)-31.9(cent)15(a)-17(ges. )]TJ 0.137 Tw T* [(Q)-16(uant)-32(i)-23.9(t)15(a)15(t)-32(i)-16(ve d)41.9(a)15(t)15.1(a w)-12(as summar)-37(ised b)12(y mean, st)15(and)42(ar)-24(d )]TJ 0.341 Tw T* [(dev)-16(ia)15(t)-32(ion. )0.6(Com)10(p)32(ar)-37(ison )0.5(of)]TJ /Span<>> BDC ( )Tj EMC 11.317 0 Td [(ca)15(tegor)-37(ical )0.6(d)42(a)15(t)15(a )0.5(be)-12(t)-32(ween )]TJ -0.049 Tw -11.317 -1.218 Td [(t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(gr)-32(oups w)-12(as per)-24(for)-16(med b)12(y Chi squar)-23.9(e test and F)-19(isher)-9.9(s )]TJ 0.079 Tw T* [(e)-18(x)-11(a)-17(c)-15.9(t )0.5(test. )0.5(Mann-Whi)-24(tne)-10.9(y )0.5(U )0.5(test )0.5(w)-12(as )0.5(d)-16(one )0.5(t)17(o)]TJ /Span<>> BDC ( )Tj EMC 18.898 0 Td [(check )0.5(if )]TJ 0 Tw -18.898 -1.218 Td [(t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(t)-32(w)-14(o gr)-32(oups \(Elec)-16(tr)-31.9(o)-16(cauter)-24(y and Ul)56(tr)-33(asonic S)-24(calpel\) )]TJ 0.035 Tw T* [(dif)-56(fer signi\251cantl)35(y or no)17(t wi)-23.9(t)-13(h r)-24(espec)-16(t t)17(o)]TJ /Span<>> BDC ( )Tj EMC [(t)-13(he four out)]TJ 0 Tw (-)Tj T* [(come v)-15(ar)-36.9(iables.)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 303.3769 444.7359 Tm [(RESUL)18(T)27(S)]TJ 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0 Tc 0.185 Tw 10 0 0 10 303.3071 420.3799 Tm [(In t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(cur)-24(r)-24(ent stud)17.1(y, 68 p)32(a)15(t)-32(ients wer)-23.9(e gr)-32(ouped int)17(o )]TJ 0.064 Tw T* [(t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(elec)-15.9(tr)-32(o)-16(cauter)-24(y \(EC\) gr)-32(oup and t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(ul)56(tr)-32.9(asonic scal)]TJ 0 Tw (-)Tj -0.015 Tw T* [(pel \(US\) gr)-32(oup, based on t)-12.9(he)]TJ /Span<>> BDC ( )Tj EMC [(ener)-32(g)16(y dev)-16(ice used dur)-36.9(ing )]TJ 0.046 Tw T* [(t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(sur)-31.9(ger)-24(y. T)47(he)]TJ /Span<>> BDC ( )Tj EMC [(EC gr)-32(oup consisted of)]TJ /Span<>> BDC ( )Tj EMC [(31 \(45.6%\) p)32(a)]TJ 0 Tw (-)Tj T* [(t)-32(ients and t)-12.9(he)]TJ /Span<>> BDC ( )Tj EMC [(US gr)-31.9(oup had 37 \(54.4%\) p)32.1(a)15(t)-32(ients.)]TJ 0.035 Tw T* [(T)47(he basel)-31(ine char)-32.9(a)-17(c)-16(ter)-37(ist)-31.9(ics wer)-24(e com)10(p)32(ar)-33(able be)-12(t)-31.9(ween )]TJ 0.061 Tw T* [(t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(t)-32(w)-14(o gr)-32(oups. T)47(his stud)17(y incl)35(uded 41 \(60.3%\) males )]TJ 0.167 Tw T* [(and 27 \(39.7%\) females. T)47(he)]TJ /Span<>> BDC ( )Tj EMC [(mean a)-17(ge in t)-12.9(he)]TJ /Span<>> BDC ( )Tj EMC [(stud)17(y )]TJ -0.009 Tw T* [(w)-12(as 59.81)]TJ /Span<>> BDC ( )Tj EMC (+)Tj /Span<>> BDC ( )Tj EMC [(/-14.56 year)-9.9(s. M)-23.9(ost of)]TJ /Span<>> BDC ( )Tj EMC [(t)-13(he p)31.9(a)15.1(t)-32(ients wer)-23.9(e in )]TJ 0.047 Tw T* [(t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(a)-17(ge gr)-32(oup of)]TJ /Span<>> BDC ( )Tj EMC (61\22670)Tj /Span<>> BDC ( )Tj EMC [(year)-10(s \(30.9%\). T)47(he)]TJ /Span<>> BDC ( )Tj EMC (most com)Tj 0 Tw (-)Tj 0.065 Tw T* [(mon p)25(r)-24(esent)-32(ing com)10(pl)-16(aint w)-12(as p)32(ain abd)-16(omen \(44.1%\) )]TJ -0.052 Tw T* [(foll)30(o)-14(wed )0.6(b)12(y bleeding )0.5(per )0.5(r)-24(ec)-16(tum )0.5(\(30.9%\). )0.6(Diabe)-12(tes )0.5(mel)]TJ 0 Tw (-)Tj -0.028 Tw T* [(l)-31(i)-24(tus and hyper)-22(tension wer)-24(e t)-12.9(he)]TJ /Span<>> BDC ( )Tj EMC [(common comor)-24(bidi)-24(t)-32(ies )]TJ 0 Tw T* [(among t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(p)32.1(a)15(t)-32(ients.)]TJ -0.029 Tw T* [(Oper)-33(a)15(t)-32(i)-15.9(ve char)-33(a)-17(c)-16(ter)-36.9(ist)-32(ics wer)-24(e simil)-15.9(ar be)-12(t)-32(ween t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(t)-32(w)-14(o )]TJ -0.038 Tw T* [(gr)-32(oups as sho)-14(wn in T)40(able 1. Sur)-32(gical app)25(r)-32(oa)-17(ch w)-12(as open )]TJ 0.134 Tw T* [(in 29 \(42.6%\) and l)-15.9(ap)32(ar)-32(oscopic in 39 \(57.6%\) cases. )]TJ 0.066 Tw T* [(In open sur)-32(ger)-37(ies, midl)-31(ine ver)-21.9(t)-32(ical w)-12(as t)-13(he)]TJ /Span<>> BDC ( )Tj EMC (most com)Tj 0 Tw (-)Tj 0.063 Tw T* [(mon inc)-24(ision used. In l)-16(ap)32(ar)-31.9(oscopic sur)-31.9(ger)-37(ies, a)]TJ /Span<>> BDC ( )Tj EMC [(hybr)-36.9(id )]TJ 0.144 Tw T* [(app)25(r)-32(oa)-17(ch wi)-24(t)-13(h t)-13(hr)-24(ee t)17(o)]TJ /Span<>> BDC ( )Tj EMC [(\251)-16(ve por)-22(ts al)30(ong wi)-23.9(t)-13(h a)]TJ /Span<>> BDC ( )Tj EMC (mini-)Tj 0 Tw T* [(l)-16(ap)32(ar)-32(o)17(t)17.1(omy inc)-24(ision w)-11.9(as used in most of)]TJ /Span<>> BDC ( )Tj EMC [(t)-12.9(he p)32.1(a)15(t)-32(ients.)]TJ -0.037 Tw T* [(T)47(his stud)17(y incl)35(uded col)30(or)-24(ec)-16(t)15.1(al sur)-32(ger)-37(ies l)-31(ik)10(e r)-37(ight hemi)]TJ 0 Tw (-)Tj 0.052 Tw T* [(colec)-16(t)17(omy \(RH\), lef)-28(t hemicolec)-16(t)17(omy \(LH\), sigmoid col)]TJ 0 Tw (-)Tj 0.009 Tw T* [(ec)-16(t)17(omy )0.5(\(SC\) )0.6(and anter)-36.9(ior )0.5(r)-24(esec)-15.9(t)-32(ion )0.5(\(AR\). )0.5(Among )0.5(t)-12.9(hese, )]TJ 0.142 Tw T* [(31 \(45.6%\) p)25(r)-32(o)-16(cedur)-23.9(es wer)-23.9(e AR, which w)-12(as t)-13(he)]TJ /Span<>> BDC ( )Tj EMC (most )Tj 0.246 Tw T* [(per)-24(for)-15.9(med p)25(r)-31.9(o)-16(cedur)-24(e foll)30(o)-14(wed b)12(y RH, which w)-12(as 27 )]TJ 0 Tw T* (\(39.7%\).)Tj 0.243 Tw T* [(F)10(oll)30(o)-14(wing r)-23.9(esec)-16(t)-32(ion, anast)17(omosis w)-12(as per)-24(for)-16(med be)]TJ 0 Tw (-)Tj 0.317 Tw T* [(t)-32(ween t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(p)25(r)-32(o)14.1(ximal and dist)15(al ends of)]TJ /Span<>> BDC ( )Tj EMC [(t)-13(he bo)-14(wel. )]TJ 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf -0.027 Tc 0.027 Tw 9 0 0 9 70.8662 730.483 Tm [(T)0.5(a)-35.3(b)-40.7(l)-38.7(e)-27( 1)-24.5(.)]TJ 0 0 0 1 k /GS1 gs /T1_3 1 Tf 0 Tc 0 Tw 3.324 0 Td [( D)-12.1(i)6.6(s)-14.8(t)-9.5(r)-39(i)4.6(b)-1.5(u)-4.8(t)-29.1(i)-1.4(o)-4(n o)4.1(f)]TJ /Span<>> BDC ( )Tj EMC [(o)-5.2(p)-11.3(e)-6(r)3.3(a)-9.2(t)-29.1(i)-2.9(v)2.3(e v)6.4(a)-4.2(r)-39(i)1.5(a)-0.9(b)-3.4(le)-22(s a)-5(m)-5.3(o)-4(n)-0.6(g t)-10.6(h)-2.4(e)]TJ /Span<>> BDC ( )Tj EMC [(t)-22.8(w)2.2(o g)-1.5(r)-2(o)-3.4(u)-2.3(p)1.8(s i)4(n t)-10.6(h)-2.4(e)]TJ /Span<>> BDC ( )Tj EMC [(s)-14.8(t)-1.1(u)-5.9(d)-7.2(y)]TJ ET 0 0 0 1 K 0.5 w /GS2 gs q 1 0 0 1 70.8662 725.981 cm 0 0 m 107.967 0 l S Q q 1 0 0 1 71.1162 714.5117 cm 0 0 m 0 11.219 l S Q q 1 0 0 1 178.8327 725.981 cm 0 0 m 141.732 0 l S Q q 1 0 0 1 320.565 725.981 cm 0 0 m 51.024 0 l S Q q 1 0 0 1 320.565 714.7617 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 371.5886 725.981 cm 0 0 m 51.024 0 l S Q q 1 0 0 1 422.6122 725.981 cm 0 0 m 51.024 0 l S Q q 1 0 0 1 473.6359 725.981 cm 0 0 m 51.274 0 l S Q q 1 0 0 1 524.6595 714.7617 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 71.1162 703.0425 cm 0 0 m 0 11.469 l S Q q 1 0 0 1 320.315 714.5117 cm 0 0 m 51.274 0 l S Q q 1 0 0 1 320.565 703.2925 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 371.5886 714.5117 cm 0 0 m 51.024 0 l S Q q 1 0 0 1 422.6122 714.5117 cm 0 0 m 51.024 0 l S Q q 1 0 0 1 422.6122 703.2925 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 473.6359 714.5117 cm 0 0 m 51.274 0 l S Q q 1 0 0 1 524.6595 703.2925 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 71.1162 691.8233 cm 0 0 m 0 11.219 l S Q q 1 0 0 1 320.315 703.0425 cm 0 0 m 51.274 0 l S Q q 1 0 0 1 320.565 691.8233 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 371.5886 703.0425 cm 0 0 m 51.024 0 l S Q q 1 0 0 1 371.5886 691.8233 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 422.6122 703.0425 cm 0 0 m 51.024 0 l S Q q 1 0 0 1 422.6122 691.8233 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 473.6359 703.0425 cm 0 0 m 51.274 0 l S Q q 1 0 0 1 473.6359 691.8233 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 524.6595 691.8233 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 70.8662 691.5733 cm 0 0 m 107.967 0 l S Q q 1 0 0 1 71.1162 680.112 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 178.8327 691.5733 cm 0 0 m 141.732 0 l S Q q 1 0 0 1 178.8327 680.362 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 320.565 691.5733 cm 0 0 m 51.024 0 l S Q q 1 0 0 1 320.565 680.362 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 371.5886 691.5733 cm 0 0 m 51.024 0 l S Q q 1 0 0 1 371.5886 680.362 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 422.6122 691.5733 cm 0 0 m 51.024 0 l S Q q 1 0 0 1 422.6122 680.362 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 473.6359 691.5733 cm 0 0 m 51.274 0 l S Q q 1 0 0 1 473.6359 680.362 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6595 680.362 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 71.1162 668.9008 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 178.5827 680.112 cm 0 0 m 141.982 0 l S Q q 1 0 0 1 178.8327 668.9008 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 320.565 680.112 cm 0 0 m 51.024 0 l S Q q 1 0 0 1 320.565 668.9008 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 371.5886 680.112 cm 0 0 m 51.024 0 l S Q q 1 0 0 1 371.5886 668.9008 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 422.6122 680.112 cm 0 0 m 51.024 0 l S Q q 1 0 0 1 422.6122 668.9008 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 473.6359 680.112 cm 0 0 m 51.274 0 l S Q q 1 0 0 1 473.6359 668.9008 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6595 668.9008 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8662 668.6508 cm 0 0 m 107.967 0 l S Q q 1 0 0 1 71.1162 657.1895 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 178.8327 668.6508 cm 0 0 m 141.732 0 l S Q q 1 0 0 1 178.8327 657.4395 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 320.565 668.6508 cm 0 0 m 51.024 0 l S Q q 1 0 0 1 320.565 657.4395 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 371.5886 668.6508 cm 0 0 m 51.024 0 l S Q q 1 0 0 1 371.5886 657.4395 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 422.6122 668.6508 cm 0 0 m 51.024 0 l S Q q 1 0 0 1 422.6122 657.4395 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 473.6359 668.6508 cm 0 0 m 51.274 0 l S Q q 1 0 0 1 473.6359 657.4395 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6595 657.4395 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 71.1162 645.7281 cm 0 0 m 0 11.461 l S Q q 1 0 0 1 178.5827 657.1895 cm 0 0 m 141.982 0 l S Q q 1 0 0 1 178.8327 645.9781 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 320.565 657.1895 cm 0 0 m 51.024 0 l S Q q 1 0 0 1 320.565 645.9781 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 371.5886 657.1895 cm 0 0 m 51.024 0 l S Q q 1 0 0 1 371.5886 645.9781 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 422.6122 657.1895 cm 0 0 m 51.024 0 l S Q q 1 0 0 1 422.6122 645.9781 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 473.6359 657.1895 cm 0 0 m 51.274 0 l S Q q 1 0 0 1 473.6359 645.9781 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6595 645.9781 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 71.1162 634.2669 cm 0 0 m 0 11.461 l S Q q 1 0 0 1 178.5827 645.7281 cm 0 0 m 141.982 0 l S Q q 1 0 0 1 178.8327 634.5169 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 320.565 645.7281 cm 0 0 m 51.024 0 l S Q q 1 0 0 1 320.565 634.5169 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 371.5886 645.7281 cm 0 0 m 51.024 0 l S Q q 1 0 0 1 371.5886 634.5169 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 422.6122 645.7281 cm 0 0 m 51.024 0 l S Q q 1 0 0 1 422.6122 634.5169 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 473.6359 645.7281 cm 0 0 m 51.274 0 l S Q q 1 0 0 1 473.6359 634.5169 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6595 634.5169 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 71.1162 623.0556 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 178.5827 634.2669 cm 0 0 m 141.982 0 l S Q q 1 0 0 1 178.8327 623.0556 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 320.565 634.2669 cm 0 0 m 51.024 0 l S Q q 1 0 0 1 320.565 623.0556 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 371.5886 634.2669 cm 0 0 m 51.024 0 l S Q q 1 0 0 1 371.5886 623.0556 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 422.6122 634.2669 cm 0 0 m 51.024 0 l S Q q 1 0 0 1 422.6122 623.0556 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 473.6359 634.2669 cm 0 0 m 51.274 0 l S Q q 1 0 0 1 473.6359 623.0556 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6595 623.0556 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8662 622.8056 cm 0 0 m 107.967 0 l S Q q 1 0 0 1 71.1162 611.3443 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 178.8327 622.8056 cm 0 0 m 141.732 0 l S Q q 1 0 0 1 178.8327 611.5943 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 320.565 622.8056 cm 0 0 m 51.024 0 l S Q q 1 0 0 1 320.565 611.5943 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 371.5886 622.8056 cm 0 0 m 51.024 0 l S Q q 1 0 0 1 371.5886 611.5943 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 422.6122 622.8056 cm 0 0 m 51.024 0 l S Q q 1 0 0 1 422.6122 611.5943 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 473.6359 622.8056 cm 0 0 m 51.274 0 l S Q q 1 0 0 1 473.6359 611.5943 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6595 611.5943 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 71.1162 599.8831 cm 0 0 m 0 11.461 l S Q q 1 0 0 1 178.5827 611.3443 cm 0 0 m 141.982 0 l S Q q 1 0 0 1 178.8327 600.1331 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 320.565 611.3443 cm 0 0 m 51.024 0 l S Q q 1 0 0 1 320.565 600.1331 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 371.5886 611.3443 cm 0 0 m 51.024 0 l S Q q 1 0 0 1 371.5886 600.1331 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 422.6122 611.3443 cm 0 0 m 51.024 0 l S Q q 1 0 0 1 422.6122 600.1331 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 473.6359 611.3443 cm 0 0 m 51.274 0 l S Q q 1 0 0 1 473.6359 600.1331 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6595 600.1331 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 71.1162 588.4218 cm 0 0 m 0 11.461 l S Q q 1 0 0 1 178.5827 599.8831 cm 0 0 m 141.982 0 l S Q q 1 0 0 1 178.8327 588.6718 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 320.565 599.8831 cm 0 0 m 51.024 0 l S Q q 1 0 0 1 320.565 588.6718 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 371.5886 599.8831 cm 0 0 m 51.024 0 l S Q q 1 0 0 1 371.5886 588.6718 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 422.6122 599.8831 cm 0 0 m 51.024 0 l S Q q 1 0 0 1 422.6122 588.6718 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 473.6359 599.8831 cm 0 0 m 51.274 0 l S Q q 1 0 0 1 473.6359 588.6718 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6595 588.6718 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 71.1162 576.9604 cm 0 0 m 0 11.461 l S Q q 1 0 0 1 178.5827 588.4218 cm 0 0 m 141.982 0 l S Q q 1 0 0 1 178.8327 577.2104 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 320.565 588.4218 cm 0 0 m 51.024 0 l S Q q 1 0 0 1 320.565 577.2104 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 371.5886 588.4218 cm 0 0 m 51.024 0 l S Q q 1 0 0 1 371.5886 577.2104 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 422.6122 588.4218 cm 0 0 m 51.024 0 l S Q q 1 0 0 1 422.6122 577.2104 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 473.6359 588.4218 cm 0 0 m 51.274 0 l S Q q 1 0 0 1 473.6359 577.2104 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6595 577.2104 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 71.1162 565.7492 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 178.5827 576.9604 cm 0 0 m 141.982 0 l S Q q 1 0 0 1 178.8327 565.7492 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 320.565 576.9604 cm 0 0 m 51.024 0 l S Q q 1 0 0 1 320.565 565.7492 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 371.5886 576.9604 cm 0 0 m 51.024 0 l S Q q 1 0 0 1 371.5886 565.7492 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 422.6122 576.9604 cm 0 0 m 51.024 0 l S Q q 1 0 0 1 422.6122 565.7492 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 473.6359 576.9604 cm 0 0 m 51.274 0 l S Q q 1 0 0 1 473.6359 565.7492 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6595 565.7492 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8662 565.4992 cm 0 0 m 107.967 0 l S Q q 1 0 0 1 71.1162 554.0379 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 178.8327 565.4992 cm 0 0 m 141.732 0 l S Q q 1 0 0 1 178.8327 554.2879 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 320.565 565.4992 cm 0 0 m 51.024 0 l S Q q 1 0 0 1 320.565 554.2879 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 371.5886 565.4992 cm 0 0 m 51.024 0 l S Q q 1 0 0 1 371.5886 554.2879 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 422.6122 565.4992 cm 0 0 m 51.024 0 l S Q q 1 0 0 1 422.6122 554.2879 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 473.6359 565.4992 cm 0 0 m 51.274 0 l S Q q 1 0 0 1 473.6359 554.2879 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6595 554.2879 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 71.1162 542.8266 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 178.5827 554.0379 cm 0 0 m 141.982 0 l S Q q 1 0 0 1 178.8327 542.8266 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 320.565 554.0379 cm 0 0 m 51.024 0 l S Q q 1 0 0 1 320.565 542.8266 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 371.5886 554.0379 cm 0 0 m 51.024 0 l S Q q 1 0 0 1 371.5886 542.8266 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 422.6122 554.0379 cm 0 0 m 51.024 0 l S Q q 1 0 0 1 422.6122 542.8266 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 473.6359 554.0379 cm 0 0 m 51.274 0 l S Q q 1 0 0 1 473.6359 542.8266 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6595 542.8266 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8662 542.5766 cm 0 0 m 107.967 0 l S Q q 1 0 0 1 71.1162 531.1154 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 178.8327 542.5766 cm 0 0 m 141.732 0 l S Q q 1 0 0 1 178.8327 531.3654 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 320.565 542.5766 cm 0 0 m 51.024 0 l S Q q 1 0 0 1 320.565 531.3654 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 371.5886 542.5766 cm 0 0 m 51.024 0 l S Q q 1 0 0 1 371.5886 531.3654 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 422.6122 542.5766 cm 0 0 m 51.024 0 l S Q q 1 0 0 1 422.6122 531.3654 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 473.6359 542.5766 cm 0 0 m 51.274 0 l S Q q 1 0 0 1 473.6359 531.3654 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6595 531.3654 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 71.1162 519.9041 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 178.5827 531.1154 cm 0 0 m 141.982 0 l S Q q 1 0 0 1 178.8327 519.9041 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 320.565 531.1154 cm 0 0 m 51.024 0 l S Q q 1 0 0 1 320.565 519.9041 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 371.5886 531.1154 cm 0 0 m 51.024 0 l S Q q 1 0 0 1 371.5886 519.9041 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 422.6122 531.1154 cm 0 0 m 51.024 0 l S Q q 1 0 0 1 422.6122 519.9041 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 473.6359 531.1154 cm 0 0 m 51.274 0 l S Q q 1 0 0 1 473.6359 519.9041 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6595 519.9041 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8662 519.6541 cm 0 0 m 107.967 0 l S Q q 1 0 0 1 71.1162 508.1927 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 178.8327 519.6541 cm 0 0 m 141.732 0 l S Q q 1 0 0 1 178.8327 508.4427 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 320.565 519.6541 cm 0 0 m 51.024 0 l S Q q 1 0 0 1 320.565 508.4427 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 371.5886 519.6541 cm 0 0 m 51.024 0 l S Q q 1 0 0 1 371.5886 508.4427 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 422.6122 519.6541 cm 0 0 m 51.024 0 l S Q q 1 0 0 1 422.6122 508.4427 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 473.6359 519.6541 cm 0 0 m 51.274 0 l S Q q 1 0 0 1 473.6359 508.4427 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6595 508.4427 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 71.1162 496.9815 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 178.5827 508.1927 cm 0 0 m 141.982 0 l S Q q 1 0 0 1 178.8327 496.9815 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 320.565 508.1927 cm 0 0 m 51.024 0 l S Q q 1 0 0 1 320.565 496.9815 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 371.5886 508.1927 cm 0 0 m 51.024 0 l S Q q 1 0 0 1 371.5886 496.9815 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 422.6122 508.1927 cm 0 0 m 51.024 0 l S Q q 1 0 0 1 422.6122 496.9815 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 473.6359 508.1927 cm 0 0 m 51.274 0 l S Q q 1 0 0 1 473.6359 496.9815 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6595 496.9815 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8662 496.7315 cm 0 0 m 107.967 0 l S Q q 1 0 0 1 71.1162 485.2702 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 178.8327 496.7315 cm 0 0 m 141.732 0 l S Q q 1 0 0 1 178.8327 485.5202 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 320.565 496.7315 cm 0 0 m 51.024 0 l S Q q 1 0 0 1 320.565 485.5202 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 371.5886 496.7315 cm 0 0 m 51.024 0 l S Q q 1 0 0 1 371.5886 485.5202 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 422.6122 496.7315 cm 0 0 m 51.024 0 l S Q q 1 0 0 1 422.6122 485.5202 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 473.6359 496.7315 cm 0 0 m 51.274 0 l S Q q 1 0 0 1 473.6359 485.5202 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6595 485.5202 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 71.1162 474.0589 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 178.5827 485.2702 cm 0 0 m 141.982 0 l S Q q 1 0 0 1 178.8327 474.0589 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 320.565 485.2702 cm 0 0 m 51.024 0 l S Q q 1 0 0 1 320.565 474.0589 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 371.5886 485.2702 cm 0 0 m 51.024 0 l S Q q 1 0 0 1 371.5886 474.0589 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 422.6122 485.2702 cm 0 0 m 51.024 0 l S Q q 1 0 0 1 422.6122 474.0589 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 473.6359 485.2702 cm 0 0 m 51.274 0 l S Q q 1 0 0 1 473.6359 474.0589 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6595 474.0589 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8662 473.8089 cm 0 0 m 107.967 0 l S Q q 1 0 0 1 178.8327 473.8089 cm 0 0 m 141.732 0 l S Q q 1 0 0 1 320.565 473.8089 cm 0 0 m 51.024 0 l S Q q 1 0 0 1 371.5886 473.8089 cm 0 0 m 51.024 0 l S Q q 1 0 0 1 422.6122 473.8089 cm 0 0 m 51.024 0 l S Q q 1 0 0 1 473.6359 473.8089 cm 0 0 m 51.274 0 l S Q BT /GS1 gs /T1_2 1 Tf 8 0 0 8 180.1289 705.8771 Tm (Variables)Tj 27.746 1.434 Td (Device Used)Tj -6.88 -1.434 Td (Electrocautery)Tj 12.009 0 Td (Ultrasonic Scalpel)Tj -12.398 -1.434 Td (n)Tj 6.229 0 Td (%)Tj 6.527 0 Td (n)Tj 6.229 0 Td (%)Tj /T1_0 1 Tf -52.733 -1.433 Td (Approach )Tj 13.465 0 Td (Open )Tj 20.051 0 Td (11)Tj 5.6 0 Td (35.5%)Tj 7.155 0 Td (18)Tj 5.6 0 Td (48.6%)Tj -38.408 -1.433 Td (Laparoscopy )Tj 20.051 0 Td (20)Tj 5.6 0 Td (64.5%)Tj 7.155 0 Td (19)Tj 5.6 0 Td (51.4%)Tj -51.872 -1.433 Td (Incision/Ports )Tj 13.465 0 Td (4 ports)Tj /Span<>> BDC ( )Tj EMC (+)Tj /Span<>> BDC ( )Tj EMC (minilaparotomy)Tj 20.301 0 Td (1)Tj 5.6 0 Td (3.2%)Tj 7.155 0 Td (1)Tj 5.6 0 Td (2.7%)Tj -38.658 -1.433 Td (5 ports )Tj 20.301 0 Td (6)Tj 5.35 0 Td (19.4%)Tj 7.405 0 Td (2)Tj 5.6 0 Td (5.4%)Tj -38.658 -1.433 Td (5 ports)Tj /Span<>> BDC ( )Tj EMC (+)Tj /Span<>> BDC ( )Tj EMC (minilaparotomy)Tj 20.051 0 Td (13)Tj 5.6 0 Td (41.9%)Tj 7.155 0 Td (16)Tj 5.6 0 Td (43.2%)Tj -38.408 -1.433 Td (Midline vertical )Tj 20.051 0 Td (11)Tj 5.6 0 Td (35.5%)Tj 7.155 0 Td (18)Tj 5.6 0 Td (48.6%)Tj -51.872 -1.433 Td (Procedure )Tj 13.465 0 Td (Anterior resection )Tj 20.051 0 Td (17)Tj 5.6 0 Td (54.8%)Tj 7.155 0 Td (14)Tj 5.6 0 Td (37.8%)Tj -38.408 -1.433 Td (Right hemicolectomy )Tj 20.051 0 Td (12)Tj 5.6 0 Td (38.7%)Tj 7.155 0 Td (17)Tj 5.6 0 Td (45.9%)Tj -38.408 -1.433 Td (Sigmoid colectomy )Tj 20.301 0 Td (2)Tj 5.6 0 Td (6.5%)Tj 7.155 0 Td (3)Tj 5.6 0 Td (8.1%)Tj -38.658 -1.433 Td (Left hemicolectomy )Tj 20.301 0 Td (0)Tj 5.6 0 Td (0.0%)Tj 7.155 0 Td (2)Tj 5.6 0 Td (5.4%)Tj -38.658 -1.433 Td (Left hemicolectomy)Tj /Span<>> BDC ( )Tj EMC (+)Tj /Span<>> BDC ( )Tj EMC (sigmoid colectomy )Tj 20.301 0 Td (0)Tj 5.6 0 Td (0.0%)Tj 7.155 0 Td (1)Tj 5.6 0 Td (2.7%)Tj -52.122 -1.433 Td (Type of)Tj /Span<>> BDC ( )Tj EMC (anastomosis )Tj 13.465 0 Td (End to)Tj /Span<>> BDC ( )Tj EMC (End )Tj 20.051 0 Td (18)Tj 5.6 0 Td (58.1%)Tj 7.155 0 Td (17)Tj 5.6 0 Td (45.9%)Tj -38.408 -1.433 Td (Side to)Tj /Span<>> BDC ( )Tj EMC (Side )Tj 20.051 0 Td (13)Tj 5.6 0 Td (41.9%)Tj 7.155 0 Td (20)Tj 5.6 0 Td (54.1%)Tj -51.872 -1.433 Td (Technique of)Tj /Span<>> BDC ( )Tj EMC (anastomosis )Tj 13.465 0 Td (Hand-sewn )Tj 20.301 0 Td (7)Tj 5.35 0 Td (22.6%)Tj 7.405 0 Td (9)Tj 5.35 0 Td (24.3%)Tj -38.408 -1.433 Td (Stapler )Tj 20.051 0 Td (24)Tj 5.6 0 Td (77.4%)Tj 7.155 0 Td (28)Tj 5.6 0 Td (75.7%)Tj -51.872 -1.433 Td (Skin closure )Tj 13.465 0 Td (Staples )Tj 20.051 0 Td (27)Tj 5.6 0 Td (87.1%)Tj 7.155 0 Td (25)Tj 5.6 0 Td (67.6%)Tj -38.408 -1.433 Td (Sutures )Tj 20.301 0 Td (4)Tj 5.35 0 Td (12.9%)Tj 7.155 0 Td (12)Tj 5.6 0 Td (32.4%)Tj -51.872 -1.433 Td (Stoma )Tj 13.465 0 Td (Yes )Tj 20.301 0 Td (3)Tj 5.6 0 Td (9.7%)Tj 7.155 0 Td (6)Tj 5.35 0 Td (16.2%)Tj -38.408 -1.433 Td (No )Tj 20.051 0 Td (28)Tj 5.6 0 Td (90.3%)Tj 7.155 0 Td (31)Tj 5.6 0 Td (83.8%)Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\033\030\031\030\217\n)-20.9(\035\210\217\241\003 \013\032)50(\n)42(\032\210\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj -51.938 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 2)69(4, \023\0224, 202)23(5)]TJ 43.013 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 2)69(4, \023\0224, 202)23(5)]TJ /T1_5 1 Tf 25 0 0 25 20.7902 56.0378 Tm (108)Tj ET endstream endobj 1629 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\034\201\025\b\222\016\017)-9.9(\026\021\r\215\025\016 \025\211\215\025\212\016\215\026\201\025\r\025\016\ \215\001\235\t\205\211\001\026)11(\016\t\214\215\025\016 \021\b\b)-10(\t\016\211\025\r\001\215\021\016 )]TJ 0 -1 TD [(\242\215\016\201\202)10(\016\026\021\f\016\b\017\021 \200\b)-10(\026\201\025\207\b)-10(\026\r \r\022\017)10(\025\t\025\201\016\017)-10(\026)11(\001\t\214\215\025\207 \021\201\200\201\202\021\021)]TJ 41.119 1 Td [(A Pr)20(ospectiv)12(e Single Centr)31(e Obser)-20.9(v)10(ational Study )]TJ 3.383 -1 Td [(on\022Ener)31.1(gy\022De)11(vices in Color)31(ectal Sur)31(ger)-31(y)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0.157 Tw 10 0 0 10 42.5197 724.8299 Tm [(which ut)-32(il)-30.9(ize mechanical ener)-32(g)16(y, of)-56(fer p)25(r)-24(ec)-24(ise t)-32(issue )]TJ 0.229 Tw 0 -1.218 TD [(dissec)-16(t)-31.9(ion and ef)-56(fec)-16(t)-32(i)-16(ve hemost)15(asis. M)-24(onopol)-15.9(ar and )]TJ 0.205 Tw T* [(bipol)-16(ar elec)-15.9(tr)-32(o)-16(cauter)-23.9(y, al)30.1(ong wi)-24(t)-13(h ad)-17(v)-15(anced sy)-13(stems )]TJ 0.311 Tw T* [(l)-31(ik)10(e t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(R)-10(adiofr)-24(equency V)30(essel Seal)-31(ing Sy)-13(stem and )]TJ 0.085 Tw T* [(Ul)56(tr)-33(asonic S)-24(calpel, have enhanced t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(safe)-12(t)-10(y and ef\251)]TJ 0 Tw (-)Tj T* [(c)-24(iency of)]TJ /Span<>> BDC ( )Tj EMC [(t)-12.9(hese p)25(r)-32(o)-15.9(cedur)-24(es.)]TJ 0.436 Tw 0 -1.218 TD [(T)47(he ad)-17(vent of)]TJ /Span<>> BDC ( )Tj EMC [(ad)-17(v)-15(anced ener)-32(g)16(y dev)-16(ices, such as )]TJ 0.327 Tw 0 -1.218 TD [(t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(Ul)56(tr)-33(asonic S)-24(calpel and elec)-16(tr)-31.9(o)-16(cauter)-24(y, has sig)]TJ 0 Tw (-)Tj 0.262 Tw T* [(ni\251cantl)35(y enhanced t)-12.9(he)]TJ /Span<>> BDC ( )Tj EMC [(p)25(r)-24(ec)-24(ision and ef)-56(fec)-15.9(t)-32(i)-16(veness )]TJ 0.11 Tw T* (of)Tj /Span<>> BDC ( )Tj EMC [(t)-13(hese sur)-32(gical p)25(r)-32(o)-16(cedur)-23.9(es. T)47(hese dev)-16(ices of)-55.9(fer dis)]TJ 0 Tw (-)Tj 0.105 Tw T* [(t)-32(inc)-16(t ad)-17(v)-15(ant)15(a)-17(ges in t)-32(issue dissec)-15.9(t)-32(ion and hemost)15(asis, )]TJ 0.211 Tw T* [(cr)-22(uc)-23.9(ial for minimizing )0.5(intr)-33(aoper)-32.9(a)14.9(t)-31.9(i)-16(ve bl)30(o)-16(od l)30(oss and )]TJ 0 Tw 0 -1.218 TD [(r)-24(educ)-23.9(ing post)17(oper)-33(a)15(t)-32(i)-15.9(ve com)10(pl)-31(ica)15(t)-31.9(ions.)]TJ 0.072 Tw 0 -1.218 TD [(T)47(he Ul)56(tr)-32.9(asonic S)-24(calpel ut)-32(il)-31(izes ul)56(tr)-32.9(asonic ener)-32(g)16(y t)17(o)]TJ /Span<>> BDC ( )Tj EMC (si)Tj 0 Tw (-)Tj 0.403 Tw 0 -1.218 TD [(mul)56(t)15(aneousl)35.1(y cut and coa)-17(gul)-16(a)15(te t)-31.9(issues, p)25(r)-32(ov)-16(iding )]TJ 0.045 Tw T* (a)Tj /Span<>> BDC ( )Tj EMC (unique blend of)Tj /Span<>> BDC ( )Tj EMC [(mechanical and t)-13(her)-16(mal ener)-32(g)16(y t)-13(ha)15(t )]TJ 0.066 Tw T* [(r)-24(esul)56.1(ts in p)25(r)-24(ec)-24(ise t)-32(issue handl)-30.9(ing wi)-24(t)-13(h minimal l)-16(a)15(ter)-33(al )]TJ 0.309 Tw T* [(t)-13(her)-16(mal d)42(ama)-17(ge. In contr)-33(ast, elec)-15.9(tr)-32(o)-16(cauter)-23.9(y, which )]TJ 0.153 Tw T* [(can be used in monopol)-16(ar or bipol)-16(ar modes, em)10(pl)30(oy)-12.9(s )]TJ 0.257 Tw T* [(high-fr)-23.9(equency elec)-16(tr)-36.9(ical cur)-24(r)-24(ents t)17(o)]TJ /Span<>> BDC ( )Tj EMC [(a)-17(chieve t)-31.9(issue )]TJ 0.29 Tw T* [(dissec)-16(t)-31.9(ion and hemost)15.1(asis t)-13(hr)-32(ough contr)-31.9(olled t)-13(her)]TJ 0 Tw 21.758 0 Td (-)Tj 0.15 Tw -21.758 -1.218 Td [(mal ef)-56(fec)-16(ts. Bo)17(t)-13(h technol)30.1(o)-16(gies have become integr)-33(al )]TJ 0.083 Tw T* [(t)17(o)]TJ /Span<>> BDC ( )Tj EMC [(moder)-15(n sur)-32(gical p)25(r)-33(a)-17(c)-16(t)-32(ice, ye)-11.9(t t)-13(heir com)10(p)32(ar)-33(a)15(t)-32(i)-16(ve ef)]TJ 0 Tw (-)Tj 0.116 Tw T* [(\251ca)-17(cy and safe)-12(t)-9.9(y in col)30(or)-24(ec)-16(t)15(al sur)-32(ger)-36.9(ies r)-24(emain ar)-24(eas )]TJ 0 Tw T* (of)Tj /Span<>> BDC ( )Tj EMC [(a)-17(c)-16(t)-31.9(i)-16(ve invest)-31.9(iga)15(t)-32(ion.)]TJ 0.014 Tc 0.242 Tw T* [(T)47(his obser)-32(v)-15(a)15.1(t)-32(ional stud)17(y aims t)17(o)]TJ /Span<>> BDC ( )Tj EMC [(ev)-15(al)35(ua)15(te t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(use)14( )]TJ 0.464 Tw T* (of)Tj /Span<>> BDC ( )Tj EMC [(t)-13(he Ul)56(tr)-32.9(asonic S)-24(calpel and elec)-16(tr)-32(o)-16(cauter)-23.9(y in)14( )]TJ 0.059 Tw T* [(col)30(or)-23.9(ec)-16(t)15(al sur)-32(ger)-37(ies, fo)-16(cusing on v)-15(ar)-36.9(ious intr)-33(aoper)-32.9(a)]TJ 0 Tc 0 Tw (-)Tj 0.014 Tc -0.034 Tw T* [(t)-32(i)-16(ve and post)17(oper)-33(a)15(t)-31.9(i)-16(ve p)32(ar)-32.9(ame)-12(ter)-9.9(s. By e)-18(x)-11(amining f)16(a)-17(c)]TJ 0 Tc 0 Tw (-)Tj 0.014 Tc 0.053 Tw T* [(t)17(or)-9.9(s such as oper)-33(a)15(t)-31.9(i)-16(ve t)-32(ime, bl)30(o)-16(od l)30(oss, com)10(pl)-31(ica)15(t)-32(ion)14( )]TJ 0.094 Tw T* [(r)-33(a)15.1(tes, and over)-32.9(all p)32(a)15(t)-32(ient outcomes, t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(stud)17.1(y seek)-10(s)14( )]TJ 0.364 Tw T* [(t)17(o)]TJ /Span<>> BDC ( )Tj EMC [(p)25(r)-32(ov)-16(ide a)]TJ /Span<>> BDC ( )Tj EMC [(com)10(p)25(r)-23.9(ehensi)-15.9(ve assess)26(ment of)]TJ /Span<>> BDC ( )Tj EMC [(t)-13(hese)14( )]TJ 0.344 Tw T* [(ener)-31.9(g)16(y dev)-16(ices in cl)-31(inical p)25(r)-33(a)-17(c)-16(t)-31.9(ice. T)47(hr)-31.9(ough t)-12.9(his)14( )]TJ 0.061 Tw T* [(anal)35(y)-12.9(sis, )0.5(t)-12.9(he)]TJ /Span<>> BDC ( )Tj EMC 5.503 0 Td [(stud)17.1(y )0.5(intends )0.5(t)17(o)]TJ /Span<>> BDC ( )Tj EMC 7.165 0 Td [(of)-56(fer )0.5(v)-15(al)35(uable )0.5(insights)14( )]TJ 0.108 Tw -12.668 -1.218 Td [(int)17(o t)-12.9(he)]TJ /Span<>> BDC ( )Tj EMC [(ad)-17(v)-15(ant)15.1(a)-17(ges and l)-30.9(imi)-24(t)15(a)15(t)-31.9(ions of)]TJ /Span<>> BDC ( )Tj EMC [(ea)-17(ch dev)-16(ice,)14( )]TJ 0.098 Tw T* [(t)-13(her)-23.9(eb)12(y )0.5(infor)-16(ming )0.5(sur)-32(gical )0.5(dec)-24(ision-mak)-15.9(ing )0.5(and )0.5(po)]TJ 0 Tc 0 Tw (-)Tj 0.014 Tc 0.128 Tw T* [(tent)-31.9(iall)35(y guiding t)-12.9(he)]TJ /Span<>> BDC ( )Tj EMC [(devel)30(opment of)]TJ /Span<>> BDC ( )Tj EMC [(best p)25.1(r)-33(a)-17(c)-16(t)-32(ices)14( )]TJ 0 Tw T* [(in col)30(or)-24(ec)-15.9(t)15(al sur)-32(ger)-24(y.)]TJ 0.016 Tc 0.11 Tw T* [(Many p)25(r)-31.9(ospec)-16(t)-32(i)-15.9(ve studies have been d)-16(one in r)-24(ecent)16( )]TJ 0.058 Tw T* [(t)-32(imes t)17(o)]TJ /Span<>> BDC ( )Tj EMC 3.8 0 Td [(assess t)-13(he)]TJ /Span<>> BDC ( )Tj EMC (outcomes of)Tj /Span<>> BDC ( )Tj EMC [(sur)-32(ger)-37(ies )0.5(using )0.5(dif)]TJ 0 Tc 0 Tw (-)Tj 0.016 Tc 0.169 Tw -3.8 -1.218 Td [(fer)-23.9(ent ener)-31.9(g)16(y dev)-16(ices. S)-16(hor)-22(t-ter)-16(m outcomes of)]TJ /Span<>> BDC ( )Tj EMC (en)Tj 0 Tc 0 Tw (-)Tj 0.016 Tc 0.312 Tw T* [(er)-32(g)16(y )0.5(dev)-16(ices l)-31(ik)10(e )0.5(t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(R)-10(adiofr)-24(equency scalpel and)16( )]TJ 0.14 Tw T* [(Ul)56(tr)-32.9(asonic S)-24(calpel have been obser)-32(ved t)17(o)]TJ /Span<>> BDC ( )Tj EMC [(be be)-12(t)-30(ter)16( )]TJ 0.29 Tw T* [(t)-13(han convent)-32(ional elec)-15.9(tr)-32(osur)-31.9(ger)-24(y. Cer)-22(t)15.1(ain aut)-13(hor)-10(s)16( )]TJ 0.171 Tw T* [(have found t)-13(ha)15(t t)-13(he)]TJ /Span<>> BDC ( )Tj EMC (use of)Tj /Span<>> BDC ( )Tj EMC [(R)-10(adiofr)-23.9(equency scalpel)16( )]TJ 0.401 Tw T* [(dur)-36.9(ing l)-16(ap)32(ar)-32(oscopic col)30(or)-23.9(ec)-16(t)15(al sur)-32(ger)-24(y r)-23.9(esul)56(ts in)16( )]TJ 0.13 Tw T* [(shor)-21.9(ter sur)-32(gical t)-32(imes and r)-24(educed bl)30(o)-16(od l)30(oss com)]TJ 0 Tc 0 Tw (-)Tj 0.016 Tc 0.243 Tw T* [(p)32(ar)-24(ed )0.5(t)17(o)]TJ /Span<>> BDC ( )Tj EMC 4.169 0 Td [(t)-13(he )0.5(use )0.5(of)]TJ /Span<>> BDC ( )Tj EMC 5.142 0 Td [(ul)56(tr)-33(asonic )0.6(coa)-17(gul)-16(a)15(t)-32(ing )0.5(shear)-9.9(s)16( )]TJ 0.107 Tw -9.311 -1.218 Td [(\(UCS\). In contr)-33(ast, a)]TJ /Span<>> BDC ( )Tj EMC [(r)-24(ecent stud)17(y sho)-14(wed t)-12.9(ha)15(t dur)]TJ 0 Tc 0 Tw 21.758 0 Td (-)Tj 0.016 Tc 0.219 Tw -21.758 -1.218 Td [(ing l)-16(ap)32(ar)-32(oscopic col)30(or)-24(ec)-16(t)15.1(al sur)-32(ger)-24(y, t)-13(her)-23.9(e wer)-23.9(e no)16( )]TJ 0.117 Tw T* [(app)25(r)-24(ec)-24(iable v)-15(ar)-37(ia)15(t)-31.9(ions in t)-12.9(he)]TJ /Span<>> BDC ( )Tj EMC [(shor)-21.9(t-ter)-16(m r)-24(esul)56.1(ts be)]TJ 0 Tc 0 Tw (-)Tj 0.016 Tc 0.213 Tw T* [(t)-32(ween UCS and R)-10(adiofr)-24(equency scalpel. Ul)56.1(t)-32(ima)15(tel)35(y,)16( )]TJ 0.174 Tw T* [(t)-13(he)]TJ /Span<>> BDC ( )Tj EMC (choice of)Tj /Span<>> BDC ( )Tj EMC [(dev)-16(ice used must be as per t)-13(he)]TJ /Span<>> BDC ( )Tj EMC (sur)Tj 0 Tc 0 Tw 21.758 0 Td (-)Tj 0.016 Tc -21.758 -1.218 Td [(geon\246s p)25(r)-24(efer)-23.9(ence [1].)]TJ 0 Tc 0.064 Tw 23.244 64.543 Td (In a)Tj /Span<>> BDC ( )Tj EMC [(stud)17(y b)12(y Cam)10(p)32(a)-16.9(gna)-17(cc)-24(i e)-11.9(t al. in 2007 \(It)15(al)35(y\), elec)]TJ 0 Tw (-)Tj 0.059 Tw T* [(tr)-32(o)17(t)-13(her)-15.9(mal bipol)-16(ar vessel seal)-31(ing \(EB)10(V)27(S\) and UCS wer)-24(e )]TJ 0.289 Tw T* [(com)10(p)32(ar)-24(ed )0.5(in )0.5(l)-15.9(ap)32(ar)-32(oscopic )0.5(colec)-16(t)17.1(omies. )0.5(R)-24(ight )0.5(colec)]TJ 0 Tw (-)Tj 0.054 Tw T* [(t)17(omy, lef)-28(t colec)-16(t)17.1(omy, and l)30(o)-14(w anter)-36.9(ior r)-24(esec)-16(t)-32(ions wer)-23.9(e )]TJ -0.054 Tw T* [(t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(sur)-32(ger)-37(ies per)-23.9(for)-16(med. N)-14(o st)15(a)15(t)-32(ist)-32(icall)35.1(y signi\251cant dif)]TJ 0 Tw (-)Tj -0.039 Tw T* [(fer)-24(ences in t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(mean dur)-33(a)15(t)-32(ion of)]TJ /Span<>> BDC ( )Tj EMC [(sur)-31.9(ger)-24(y or in t)-13(he)]TJ /Span<>> BDC ( )Tj EMC (mean )Tj 0.341 Tw 0 -1.218 TD [(post-oper)-32.9(a)15(t)-32(i)-16(ve st)15(a)15(y wer)-23.9(e obser)-32(ved among t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(t)-31.9(w)-14(o )]TJ 0.124 Tw 0 -1.218 TD [(gr)-32(oups. Ho)-14(wever, t)-13(her)-24(e wer)-24(e dif)-56(fer)-24(ences in t)-12.9(he)]TJ /Span<>> BDC ( )Tj EMC (mean )Tj 0.036 Tw T* [(bl)30(o)-16(od l)30(oss for ea)-17(ch of)]TJ /Span<>> BDC ( )Tj EMC [(t)-13(he sur)-32(ger)-37(ies for t)-12.9(he)]TJ /Span<>> BDC ( )Tj EMC [(t)-32(w)-14(o gr)-32(oups )]TJ 0 Tw T* ([1,2].)Tj 0.016 Tc 0.12 Tw T* (In a)Tj /Span<>> BDC ( )Tj EMC [(stud)17(y b)12(y T)40(ak)-16.9(ad)42(a e)-12(t al. in 2005 \(Jap)32(an\), 30 p)32(a)]TJ 0 Tc 0 Tw (-)Tj 0.016 Tc 0.084 Tw T* [(t)-32(ients wer)-24(e incl)35.1(uded who under)-38(went tr)-33(ansver)-10(se col)]TJ 0 Tc 0 Tw (-)Tj 0.016 Tc 0.128 Tw 0 -1.218 TD [(ec)-16(t)17(omy and sigmoidec)-16(t)17.1(omy b)12(y l)-16(ap)32(ar)-32(oscopic me)-12(t)-12.9(hod)16( )]TJ 0.351 Tw 0 -1.218 TD [(for )0.5(mal)-31(ignancy. )0.5(Ei)-24(t)-13(her )0.5(t)-13(he)]TJ /Span<>> BDC ( )Tj EMC 12.631 0 Td [(EB)10(V)27(S )0.5(\(R)-9.9(adiofr)-24(equency)16( )]TJ 0.151 Tw -12.631 -1.218 Td [(scalpel\) or UCS \(Ul)56(tr)-32.9(asonic S)-24(calpel\) wer)-24(e used dur)]TJ 0 Tc 0 Tw 21.758 0 Td (-)Tj 0.016 Tc 0.107 Tw -21.758 -1.218 Td [(ing t)-12.9(he)]TJ /Span<>> BDC ( )Tj EMC [(sur)-32(ger)-24(y. T)47(hese dev)-16(ices wer)-24(e used in dissec)]TJ 0 Tc 0 Tw (-)Tj 0.016 Tc 0.044 Tw 0 -1.218 TD [(t)-32(ion of)]TJ /Span<>> BDC ( )Tj EMC [(t)-13(he meso)-15.9(col)30(on. F)10(or bo)16.9(t)-12.9(h sur)-32(gical p)25(r)-32(o)-16(cedur)-24(es,)16( )]TJ -0.01 Tw T* [(r)-24(ebleeding w)-12(as consider)-33(abl)35(y r)-24(educed for t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(gr)-32(oup in)16( )]TJ -0.011 Tw T* [(which EB)10.1(V)27(S w)-12(as used com)10(p)32(ar)-24(ed t)17(o)]TJ /Span<>> BDC ( )Tj EMC [(t)-13(he gr)-32(oup in which)16( )]TJ 0.047 Tw T* [(UCS w)-12(as used. When EB)10(V)27.1(S w)-12(as ut)-32(il)-31(ized dur)-37(ing ei)-24(t)-13(her)16.1( )]TJ 0.193 Tw T* (of)Tj /Span<>> BDC ( )Tj EMC [(t)-13(he p)25(r)-31.9(o)-16(cedur)-23.9(es, t)-13(he)]TJ /Span<>> BDC ( )Tj EMC (amount of)Tj /Span<>> BDC ( )Tj EMC [(t)-32(ime needed for)16( )]TJ 0.09 Tw T* [(meso)-15.9(col)30(on dissec)-16(t)-32(ion w)-11.9(as also signi\251cantl)35.1(y r)-24(educed)16( )]TJ -0.016 Tw T* ([2,3].)Tj 0 Tc 0.039 Tw T* [(T)47(hese r)-24(esul)56(ts wer)-23.9(e asso)-16(c)-24(ia)15(ted wi)-23.9(t)-13(h a)]TJ /Span<>> BDC ( )Tj EMC [(decr)-23.9(ease in bl)30.1(o)-16(od )]TJ 0.03 Tw T* [(l)30(oss dur)-37(ing sur)-32(ger)-23.9(y, which w)-11.9(as st)15(a)15(t)-32(ist)-31.9(icall)35(y signi\251cant. )]TJ 0.343 Tw T* [(T)47(he)]TJ /Span<>> BDC ( )Tj EMC [(convent)-31.9(ional gr)-32(oup e)-18(xper)-37(ienced a)]TJ /Span<>> BDC ( )Tj EMC [(higher r)-32.9(a)15(te )]TJ 0.04 Tw T* (of)Tj /Span<>> BDC ( )Tj EMC [(conver)-9.9(sion t)17(o)]TJ /Span<>> BDC ( )Tj EMC [(o)17.1(t)-13(her me)-12(t)-12.9(hods. T)47(her)-24(e )0.5(wer)-24(e no )0.5(signi\251)]TJ 0 Tw (-)Tj 0.104 Tw T* [(cant dif)-56(fer)-23.9(ences in immedia)15(te outcomes, l)-31(ik)10(e mor)-23.9(bid)]TJ 0 Tw (-)Tj 0.096 Tw T* [(i)-24(t)-10(y, mor)-22(t)15(al)-31(i)-24(t)-9.9(y and hospi)-23.9(t)15(al st)15(a)15(y. T)46.9(he)]TJ /Span<>> BDC ( )Tj EMC [(cost anal)35(y)-13(sis w)-12(as )]TJ 0 Tw T* [(simil)-15.9(ar be)-12(t)-32(ween t)-12.9(he)]TJ /Span<>> BDC ( )Tj EMC [(t)-13(hr)-24(ee gr)-31.9(oups [2,4].)]TJ 0.058 Tw T* [(In summar)-24(y, t)-12.9(his stud)17(y endeavor)-10(s t)17(o)]TJ /Span<>> BDC ( )Tj EMC [(contr)-37(ibute t)17(o)]TJ /Span<>> BDC ( )Tj EMC [(t)-13(he )]TJ 0.102 Tw T* [(gr)-32(o)-14(wing bod)17(y of)]TJ /Span<>> BDC ( )Tj EMC [(kno)-13.9(wledge on ener)-32(g)16(y dev)-16(ices in sur)]TJ 0 Tw 21.758 0 Td (-)Tj 0.326 Tw -21.758 -1.218 Td [(ger)-24(y, wi)-24(t)-13(h t)-13(he)]TJ /Span<>> BDC ( )Tj EMC (goal of)Tj /Span<>> BDC ( )Tj EMC [(enhanc)-24(ing sur)-32(gical ef\251ca)-16.9(cy )]TJ 0.21 Tw T* [(and p)32(a)15(t)-32(ient safe)-12(t)-10(y in t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(mana)-17(gement of)]TJ /Span<>> BDC ( )Tj EMC [(col)30(or)-23.9(ec)-16(t)15(al )]TJ 0 Tw T* (diseases.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.01 Tc 0.018 Tw 14 0 0 14 275.0305 274.2438 Tm [(AIM)5( AND)5.1( OBJECTIVES)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0 Tc -0.003 Tw 10 0 0 10 274.9606 249.8878 Tm (\243)Tj /Span<>> BDC [( )-270( )]TJ EMC 1 0 Td [(T)45(o)]TJ /Span<>> BDC ( )Tj EMC [(assess t)-13(he)]TJ /Span<>> BDC ( )Tj EMC (outcome of)Tj /Span<>> BDC ( )Tj EMC [(v)-15(ar)-37(ious ener)-31.9(g)16(y sour)-32(ces l)-31(ik)10(e )]TJ 0.203 Tw T* [(ul)56(tr)-32.9(asonic scalpel and elec)-16(tr)-32(o)-16(cauter)-24(y in col)30(or)-24(ec)-16(t)15.1(al )]TJ 0 Tw T* [(sur)-32(ger)-36.9(ies)]TJ 0.022 Tw -1 -1.218 Td (\243)Tj /Span<>> BDC [( )-245( )]TJ EMC 1 0 Td [(T)45(o)]TJ /Span<>> BDC ( )Tj EMC [(measur)-23.9(e t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(oper)-33(a)15(t)-31.9(i)-16(ve t)-32(ime, intr)-32.9(aoper)-33(a)15(t)-32(i)-16(ve )0.5(bl)30(o)-16(od )]TJ 0 Tw T* [(l)30(oss, dr)-32.9(ain output and hospi)-23.9(t)15(al st)15.1(a)15(y)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 275.0305 164.6418 Tm [(METHODOL)34(OGY)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0 Tc 0.434 Tw 10 0 0 10 274.9606 140.2858 Tm [(T)47(he cur)-24(r)-23.9(ent stud)17(y is a)]TJ /Span<>> BDC ( )Tj EMC [(p)25(r)-32(ospec)-16(t)-32(i)-16(ve, single-center, )]TJ 0.44 Tw T* [(obser)-32(v)-15(a)15.1(t)-32(ional stud)17(y conduc)-16(ted in t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(dep)32(ar)-22(tment )]TJ 0.286 Tw T* (of)Tj /Span<>> BDC ( )Tj EMC [(Gener)-33(al Sur)-32(ger)-23.9(y. T)47(he)]TJ /Span<>> BDC ( )Tj EMC [(stud)17(y per)-37(iod e)-18(xtends fr)-32(om )]TJ 0.046 Tw T* [(19.12.2022 t)17(o)]TJ /Span<>> BDC ( )Tj EMC [(30.09.2024. T)47(he)]TJ /Span<>> BDC ( )Tj EMC (number of)Tj /Span<>> BDC ( )Tj EMC [(p)32(ar)-22(t)-32(ic)-23.9(ip)32(ants )]TJ 0.062 Tw T* [(incl)35(uded )0.5(in )0.5(t)-13(he)]TJ /Span<>> BDC ( )Tj EMC 6.476 0 Td [(stud)17(y )0.5(is )0.5(68. )0.5(App)25(r)-31.9(ov)-15(al )0.5(w)-12(as )0.5(sought )0.5(fr)-31.9(om )]TJ 0.096 Tw -6.476 -1.218 Td [(t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(Inst)-32(i)-23.9(tut)-32(ional Et)-12.9(hics Commi)-24(t)-30(tee and p)32(a)15(t)-31.9(ients wer)-24(e )]TJ 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 0 Tw 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\033\030\031\030\217\n)-20.9(\035\210\217\241\003 \013\032)50(\n)42(\032\210\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj /T1_3 1 Tf 25 0 0 25 505.552 56.0378 Tm (107)Tj ET endstream endobj 1626 0 obj [1633 0 R] endobj 1627 0 obj <>stream q /GS0 gs /Fm0 Do Q 0 0 0 1 K 1 j 1 J [0 2.997]0 d /GS1 gs q 1 0 0 1 74.3631 293.4295 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 71.3661 293.4295 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q [0 2.997]0 d q 1 0 0 1 74.3631 265.8216 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 71.3661 265.8216 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q 0 j 0 J q 1 0 0 1 70.8661 221.3524 cm 0 0 m 453.543 0 l S Q BT 0 0 0 1 k /T1_0 1 Tf 10 0 0 10 70.8661 724.8299 Tm (https://doi.org/10.33878/2073-7556-2025-24-4-106-119)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0.023 Tw 19 0 0 19 112.6716 695.3259 Tm [(A Pr)20(ospectiv)12.1(e Single Centr)31(e Obser)-21(v)10(ational Study )]TJ 1.691 -1.105 Td [(on\022)-23.3(Ener)31.1(gy\022)-23.3(De)11(vices in Color)31(ectal Sur)31(ger)-30.9(y)]TJ -2.23 -1.553 Td [(\(\034\201\025\b\222\016\017)-9.9(\026\021\r\215\025\016 \025\211\215\025\212\016\215\026\201\025\r\025\016\ \215\001\235\t\205\211\001\026)11(\016\t\214\215\025\016 )]TJ 1.885 -1.105 Td [(\021\b\b)-10(\t\016\211\025\r\001\215\021\016 \242\215\016\201\202)10(\016\026\021\f\016\b\017\021 \200\b)-10(\026\201\025\207\b)-10(\026\r )]TJ 2.446 -1.105 Td [(\r\022)-23.3(\017)10(\025\t\025\201\016\017)-10(\026)11(\001\t\214\215\025\207 \021\201\200\201\202\021\021\))]TJ 0 0 0 1 k /GS1 gs 14 0 0 14 70.8661 578.3181 Tm [(Joanna Sander)-20.9(w)20(ale, Annappa K)31(udv)10(a, Jithin A)-31(. Jacob)]TJ 10 0 0 10 70.8661 560.6488 Tm [(K)41(asturba Medical college, MAHE, Manipal, K)41(arnataka, India)]TJ /T1_0 1 Tf 0.149 Tw 9 0 0 9 119.0551 542.1449 Tm [(B)20(A)26(C)13(K)38(GR)19(OUND: Adv)16(ances in colorectal surg)12(er)-43(y include energy devices for p)46(recise dissection and hemostasis. This )]TJ 0.02 Tw 0 -1.111 TD [(obser)-41.9(v)16(ational study ev)16(aluates the)]TJ /Span<>> BDC ( )Tj EMC [(ultrasonic scalpel and electrocauter)-42.9(y in colorectal surg)12(er)-36.9(ies, analyzing intra- and )]TJ 0.023 Tw T* [(postoperativ)13.1(e parameters to)]TJ /Span<>> BDC ( )Tj EMC [(infor)-13.9(m decisions and best p)46(ractices.)]TJ 0.159 Tw T* [(METHODS: Prospectiv)13(e obser)-41.9(v)16(ational study at a)]TJ /Span<>> BDC ( )Tj EMC [(ter)-40(tiar)-43(y center \(12/19/2022\22609/30/2024\). Data collected and )]TJ 0.023 Tw T* (analyzed with SPSS 23.)Tj 0.114 Tw T* [(RESUL)30(T)-10(S: Com)16(parable g)14(roups in baseline character)-36.9(istics. There w)12(ere no signif)-43(icant dif)-39.9(ferences in operativ)13(e time, )]TJ 0.047 Tw T* [(intraoperativ)13.1(e bleeding, postoperativ)13.1(e drainag)12(e \(48h\), or hospital stay betw)12(een the)]TJ /Span<>> BDC ( )Tj EMC (ultrasonic scalpel and electro)Tj 0 Tw (-)Tj T* [(cauter)-42.9(y)32(.)]TJ -0.014 Tw 0 -1.111 TD [(C)21(ON)22(CLUSION: )0.6(The)]TJ /Span<>> BDC ( )Tj EMC 6.973 0 Td [(ultrasonic )0.6(scalpel )0.6(and )0.6(electrocauter)-42.9(y )0.6(are )0.6(v)16(aluable )0.6(tools )0.6(for )0.6(dissection )0.6(and )0.6(hemostasis )0.6(in )0.5(colorectal )]TJ -0.01 Tw -6.973 -1.111 Td [(surg)12(er)-43(y)42(, crucial for ef)-40(fectiv)13.1(e and safe minimally in)11(v)16(asiv)13(e app)46(roaches. Long-ter)-14(m ef)-40(fects should be deter)-14(mined. S)28(tudy )]TJ 0.023 Tw 0 -1.111 TD [(app)46(rov)13(ed \(IEC2:474/2022\) and registered \(CTRI/2022/12/048254\).)]TJ /T1_2 1 Tf 0.01 Tc -0.01 Tw 8 0 0 8 70.9061 426.8757 Tm [(KEYW)22(ORDS:)]TJ /T1_0 1 Tf 0 Tc 0.023 Tw 4.948 0 Td [( har)-14(monic, electrosurg)12.1(er)-43(y)42(, colorectal, monopolar)]TJ /T1_2 1 Tf 0.01 Tc -0.01 Tw -4.948 -1.909 Td [(L)-33(IMI)-17.9(T)50.9(A)46.1(TIONS:)]TJ /T1_0 1 Tf 0 Tc 0.043 Tw 5.743 0 Td [( this w)13(as a)]TJ /Span<>> BDC ( )Tj EMC [(sing)13(le center study with limited sam)16(ple size and uneq)14(ual distr)-37(ibution betw)12(een the)]TJ /Span<>> BDC ( )Tj EMC [(tw)12.1(o g)14(roups. There w)13(as no follow up )]TJ 0.023 Tw -5.748 -1.2 Td (of)Tj /Span<>> BDC ( )Tj EMC [(the patients. F)24(ur)-40(ther studies to)]TJ /Span<>> BDC ( )Tj EMC [(deter)-14(mine the)]TJ /Span<>> BDC ( )Tj EMC [(cost benef)-42.9(it and long-ter)-13.9(m ef)-39.9(fects of)]TJ /Span<>> BDC ( )Tj EMC [(v)16(ar)-36.9(ious energy devices are req)14(uired.)]TJ /T1_2 1 Tf 0.01 Tc 0.018 Tw 0.005 -1.909 Td [(C)19(ONFL)-33(ICT)5( OF)]TJ /Span<>> BDC 5.312 0 Td ( )Tj EMC [(INTE)25(REST)61.9(:)]TJ /T1_0 1 Tf 0 Tc 0.023 Tw 4.559 0 Td ( all the)Tj /Span<>> BDC ( )Tj EMC [(o)13(thers declare that they hav)13(e gone through the)]TJ /Span<>> BDC ( )Tj EMC [(manuscr)-37(ip)13(t and hav)13(e no conf)-21.9(lict of)]TJ /Span<>> BDC ( )Tj EMC (interest.)Tj /T1_2 1 Tf 0.01 Tc 0.02 Tw -9.871 -1.909 Td [(FUNDIN)23(G)5( DECL)-18(ARAION:)]TJ /T1_0 1 Tf 0 Tc 0.025 Tw 9.892 0 Td [( no funding has been receiv)13.1(ed from the)]TJ /Span<>> BDC ( )Tj EMC [(e)-15(xter)-13.9(nal sources for this study and all the)]TJ /Span<>> BDC ( )Tj EMC [(charg)12(es incur)-15.9(red dur)-36.9(ing the)]TJ /Span<>> BDC ( )Tj EMC (study are )Tj 0.023 Tw -9.897 -1.2 Td [(cov)13(ered withing the)]TJ /Span<>> BDC ( )Tj EMC [(nor)-13.9(mal treatment p)46(ro)13(tocol of)]TJ /Span<>> BDC ( )Tj EMC [(the hospital under MA)36(HE, Manipal.)]TJ /T1_2 1 Tf 0.01 Tc 0.021 Tw 0.005 -1.909 Td [(C)19(ONSENT)5( T)12(O)]TJ /Span<>> BDC 5.142 0 Td ( )Tj EMC [(P)39(ARTICIP)38.9(A)46.1(TE:)]TJ /T1_0 1 Tf 0 Tc 0.026 Tw 5.935 0 Td ( all the)Tj /Span<>> BDC ( )Tj EMC (individuals included in the)Tj /Span<>> BDC ( )Tj EMC [(study hav)13(e been e)-15(xplained about the)]TJ /Span<>> BDC ( )Tj EMC [(study -the aims, objectiv)13(es, methodology)-13.9(- in )]TJ 0.023 Tw -11.082 -1.2 Td (the)Tj /Span<>> BDC ( )Tj EMC [(best possible w)13(ay in a)]TJ /Span<>> BDC ( )Tj EMC [(languag)12.1(e that they understand and hav)13(e consented to)]TJ /Span<>> BDC ( )Tj EMC (the same.)Tj /T1_2 1 Tf 0.01 Tc 0.102 Tw 0.005 -1.909 Td [(HUMA)31(N)5( ETHICS)5( A)31(ND)5( P)39(ARTICIP)39(A)46(TION)5( C)19(ONSENT)62(:)]TJ /T1_0 1 Tf 0 Tc 0.107 Tw 19.736 0 Td ( the)Tj /Span<>> BDC ( )Tj EMC [(study has been car)-15.9(r)-37(ied as per the)]TJ /Span<>> BDC ( )Tj EMC (Declaration of)Tj /Span<>> BDC ( )Tj EMC (Helsinki and has been scrutinized and )Tj 0.13 Tw -19.741 -1.2 Td [(app)46(rov)13(ed at multiple lev)13(els by the)]TJ /Span<>> BDC ( )Tj EMC (institutional ethics committee)Tj /Span<>> BDC ( )Tj EMC (\227 IEC2:474/2022 and has been registered with the)Tj /Span<>> BDC ( )Tj EMC [(Clinical T)56(rails R)21(egistr)-42.9(y )]TJ 0.023 Tw 0 -1.2 TD (of)Tj /Span<>> BDC ( )Tj EMC (India CTRI/2022/12/048254)Tj /T1_2 1 Tf 0.025 Tc -0.044 Tw 0.005 -2.617 Td [(F)3.5(O)-4.3(R)9( C)-17.2(I)-15.3(T)45.7(A)37.8(T)-24.2(I)-1(ON:)]TJ /T1_3 1 Tf 0.011 Tc -0.035 Tw 6.241 0 Td [( J)-9.7(o)-17.9(a)-7.3(n)-5.4(n)-7.5(a)]TJ /Span<>> BDC ( )Tj EMC [(S)-26.8(a)-7.3(n)-14.2(d)-15(e)-11.8(r)-51(w)-22.1(a)-11.1(l)-23.4(e)-28.9(, A)-12.3(n)-5.4(n)-7.5(a)-8.5(p)-12.1(p)-19.7(a)]TJ /Span<>> BDC ( )Tj EMC [(K)-15.6(u)-10.2(d)-17.4(v)-28.1(a)-36.7(, J)-15.6(i)-15.5(t)-25.8(h)-13.8(i)-2.8(n A)-22.7(. J)-5.3(a)-10.8(c)-6.2(o)-11.3(b. A)]TJ /Span<>> BDC ( )Tj EMC [(P)-18.2(r)-15.5(o)-15.6(s)-9(p)-24.4(e)-18.8(c)-41.2(t)-45.9(i)-14.2(v)-18.4(e)]TJ /Span<>> BDC ( )Tj EMC [(S)-1.1(i)-2.9(n)-11.6(g)-11.5(l)-23.4(e C)-18.9(e)-11.2(n)-17(t)-30.5(r)-18.8(e)]TJ /Span<>> BDC ( )Tj EMC [(O)-13.4(b)-17.4(s)-22.6(e)-11.8(r)-58(v)-28.1(a)-17.9(t)-45.9(i)-6.5(o)-8.9(n)-7.5(a)-11.2(l S)-2.9(t)-22(u)-10.1(d)-20.2(y o)-8.9(n E)-0.6(n)-15.8(e)-11.8(r)-16.4(g)-33.3(y)]TJ /Span<>> BDC ( )Tj EMC [(D)-21.6(e)-15.5(v)-51.5(i)-4.7(c)-9.4(e)-22.5(s)11( )]TJ 0.023 Tc 0.024 Tw -6.246 -1.2 Td [(i)-3.2(n C)-16.4(o)-15.6(l)-20.9(o)-11.8(r)-19.1(e)-19.1(c)-41.5(t)-36.8(a)-11.4(l)]TJ /Span<>> BDC ( )Tj EMC [(S)-12.2(u)-7.5(r)-16.7(g)-14.4(e)-12.1(r)-60.6(y)18.1(. )]TJ /T1_0 1 Tf 0.033 Tc -0.033 Tw [(K)13.9(ol)3.7(op)2.4(r)3.1(o)3.4(k)-19.2(t)2.2(ol)3.6(o)-3.3(g)-13.2(i)6.7(a)5.8(.)]TJ /T1_3 1 Tf 0.023 Tc 0.024 Tw 16.756 0 Td [( 2)-8.9(0)-3.8(2)-1.4(5)23.3(;)9.8(2)8.8(4)-13.5(\()40.1(4)30.3(\))14.5(:)20.9(1)14(0)-15.9(6)-25.9(\226)50.8(1)29.8(1)11.6(9)23.4(. \()-0.9(i)-3.2(n R)-6.5(u)-21.9(s)-22.3(s)-15.5(.)43.2(\))10.4(. h)-17.1(t)-49.5(t)-29.3(p)-18.7(s)-8(:)1.9(/)84.7(/)36.4(d)-11.1(o)-12.5(i.)2.7(o)-11.8(r)-16.7(g)-22.8(/)11.2(1)14(0)6.5(.)-5.6(3)7.9(3)-15.9(8)1.3(7)4.6(8/)7.9(2)-8.9(0)9.3(7)-2(3)-13.2(-)41.2(7)10.7(55)-8.9(6)-26.8(-)9.8(2)-9(0)-3.8(2)-1.4(5)-23.5(-)9.7(2)8.8(4)-28.5(-)-30.3(4)-28.5(-)55.1(1)14(0)-15.9(6)-26.7(-)55.2(1)29.7(1)11.6(9)]TJ /T1_2 1 Tf 0.01 Tc -0.04 Tw -16.751 -2.617 Td [(ADDRESS)4.9( F)13(OR)5( C)18.9(ORRESPONDEN)23(CE:)]TJ /T1_0 1 Tf 0 Tc -0.035 Tw 13.935 0 Td [( Dr)51(. Jithin A)12(braham Jacob, Assistant p)46(rofessor in the)]TJ /Span<>> BDC ( )Tj EMC [(Depar)-39.9(tment of)]TJ /Span<>> BDC ( )Tj EMC [(General Surg)12(er)-42.9(y at KMC, Manipal. Af)-39.9(f)-43(iliated )]TJ 0.031 Tw -13.94 -1.2 Td (to)Tj /Span<>> BDC ( )Tj EMC [(an institute with high reg)12(ard for research and publications, K)17(asturba Medical colleg)12(e, MA)36(HE, Manipal, K)17(ar)-14(natak)11.1(a, India, Ph: 00919632883146, )]TJ 0.023 Tw T* (E-mail: jithin.abraham@manipal.edu)Tj 0 Tw 0 -2.792 TD (\n\037\035\037 \f\034\024\035\023\f\027\016\020\022\030)Tj /Span<>> BDC ( )Tj EMC (\227 04.08.2025)Tj /Span<>> BDC ( )Tj EMC 19.488 0 Td (\t\034\024\027\016 \b\034\033\037\025\034\035\021\022)Tj /Span<>> BDC ( )Tj EMC (\227 01.09.2-25)Tj /Span<>> BDC ( )Tj EMC 18.78 0 Td (\t\033\022\020\030\035\034 \021)Tj /Span<>> BDC ( )Tj EMC (\f\023\025\027\022\021\037\007\022\022)Tj /Span<>> BDC ( )Tj EMC (\227 10.11.2025)Tj ( )Tj -38.268 -1.375 Td (Received)Tj /Span<>> BDC ( )Tj EMC (\227 04.08.2025)Tj /Span<>> BDC ( )Tj EMC 19.488 0 Td (Revised)Tj /Span<>> BDC ( )Tj EMC (\227 01.09.2-25)Tj /Span<>> BDC ( )Tj EMC 18.78 0 Td (Accepted for publication)Tj /Span<>> BDC ( )Tj EMC (\227 10.11.2025)Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 70.936 164.6418 Tm (INTRODUCTION)Tj 0 0 0 1 k /GS1 gs /T1_3 1 Tf 0 Tc 0.203 Tw 10 0 0 10 70.8661 140.2859 Tm [(U)13(nder)-10(st)15(anding t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(ana)15(t)17(omy and devel)30(opment of)]TJ /Span<>> BDC ( )Tj EMC [(t)-12.9(he )]TJ 0.718 Tw 0 -1.218 TD [(l)-16(ar)-32(ge intest)-31.9(ine is essent)-31.9(ial for com)10(p)25(r)-23.9(ehending )]TJ 0.026 Tw T* [(t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(p)32(a)15(t)-13(hophy)-13(siol)30.1(o)-16(g)16(y of)]TJ /Span<>> BDC ( )Tj EMC [(v)-15(ar)-37(ious col)30(or)-24(ec)-16(t)15(al diseases and )]TJ 0.165 Tw T* [(for per)-24(for)-15.9(ming sur)-32(gical inter)-32(vent)-32(ions. Col)30.1(or)-24(ec)-16(t)15(al sur)]TJ 0 Tw 21.758 0 Td (-)Tj 0.018 Tw -21.758 -1.218 Td [(ger)-37(ies of)-28(ten r)-24(equir)-24(e t)-12.9(he)]TJ /Span<>> BDC ( )Tj EMC [(r)-24(esec)-15.9(t)-32(ion of)]TJ /Span<>> BDC ( )Tj EMC [(p)32(ar)-21.9(ts of)]TJ /Span<>> BDC ( )Tj EMC [(t)-12.9(he col)30(on )]TJ -0.03 Tw T* [(or r)-24(ec)-16(tum and t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(cr)-24(ea)15(t)-31.9(ion of)]TJ /Span<>> BDC ( )Tj EMC [(an anast)17(omosis t)17(o)]TJ /Span<>> BDC ( )Tj EMC [(r)-24(est)17(or)-23.9(e )]TJ -0.041 Tw 23.244 8.525 Td [(bo)-14(wel cont)-32(inui)-24(t)-10(y. )0.5(T)47(he)]TJ /Span<>> BDC ( )Tj EMC [(choice be)-12(t)-32(ween )0.5(l)-16(ap)32(ar)-32(oscopic )0.5(and )]TJ 0.037 Tw T* [(convent)-32(ional sur)-32(gical app)25(r)-32(oa)-17(ches depends on mul)56(t)-32(iple )]TJ 0.005 Tw T* [(f)16(a)-17(c)-16(t)17(or)-10(s, incl)35.1(uding t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(sur)-32(geon\246s e)-18(xper)-36.9(ience and t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(p)32(a)]TJ 0 Tw (-)Tj T* [(t)-32(ient\246s spec)-23.9(i\251c condi)-23.9(t)-32(ion.)]TJ 0.615 Tw T* [(A)15(d)-17(v)-15(ancements in sur)-32(gical )0.5(techniques, p)32(ar)-22(t)-32(icul)-15.9(ar)]TJ 0 Tw 21.758 0 Td (-)Tj 0.375 Tw -21.758 -1.218 Td [(l)35(y t)-12.9(he)]TJ /Span<>> BDC ( )Tj EMC (use of)Tj /Span<>> BDC ( )Tj EMC [(ener)-32(g)16(y dev)-16(ices, have r)-24(evol)35(ut)-32(ionized )]TJ 0.205 Tw T* [(col)30(or)-24(ec)-16(t)15.1(al sur)-31.9(ger)-37(ies. Elec)-16(tr)-32(osur)-31.9(ger)-24(y, em)10(pl)30(oying high-)]TJ 0.268 Tw T* [(fr)-24(equency elec)-16(tr)-37(ical cur)-23.9(r)-24(ent, and ul)56(tr)-33(asonic dev)-15.9(ices, )]TJ ET 1 0.68 0 0.12 k /GS0 gs q 1 0 0 1 70.8661 550.6489 cm 0 0 m 0 0 l 0 -11.339 l 42.52 -11.339 l 42.52 0 l h f Q BT 0 0 0 0 k /T1_2 1 Tf 0 Tw 9 0 0 9 73.5728 541.7216 Tm (ABSTRACT)Tj 1 0.68 0 0.12 k /T1_1 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\033\030\031\030\217\n)-20.9(\035\210\217\241\003 \013\032)50(\n)42(\032\210\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj -51.938 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 2)69(4, \023\0224, 202)23(5)]TJ 43.013 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 2)69(4, \023\0224, 202)23(5)]TJ /T1_5 1 Tf 25 0 0 25 20.7776 56.0378 Tm (106)Tj ET q 0 g 0 G /Fm1 Do Q 0 0 0 0 k 396.85 725.67 59.155 11.338 re f /PlacedPDF /MC0 BDC q 397.481 736.808 m 397.242 736.808 397.049 736.616 397.049 736.376 c 397.049 736.376 l 397.049 726.285 l 397.049 726.045 397.242 725.853 397.481 725.853 c 397.481 725.853 l 455.382 725.853 l 455.62 725.853 455.815 726.045 455.815 726.285 c 455.815 726.285 l 455.815 736.376 l 455.815 736.616 455.62 736.808 455.382 736.808 c 455.382 736.808 l h W n q 0 g -0.0000005 -10.9560913 -10.9560913 0.0000005 426.4320445 736.8086309 cm BX /Sh0 sh EX Q Q q 396.85 725.67 59.155 11.337 re W n 0 0 0 0.84 k q 1 0 0 1 413.5634 732.4249 cm 0 0 m -0.025 0.1 -0.063 0.196 -0.112 0.287 c -0.157 0.374 -0.218 0.451 -0.292 0.515 c -0.37 0.582 -0.46 0.632 -0.558 0.664 c -0.669 0.701 -0.786 0.719 -0.903 0.717 c -1.076 0.722 -1.247 0.681 -1.4 0.6 c -1.536 0.526 -1.652 0.42 -1.74 0.292 c -1.83 0.158 -1.895 0.008 -1.934 -0.149 c -2.018 -0.48 -2.018 -0.827 -1.934 -1.158 c -1.896 -1.316 -1.83 -1.466 -1.74 -1.602 c -1.653 -1.731 -1.536 -1.837 -1.4 -1.912 c -1.247 -1.993 -1.076 -2.033 -0.903 -2.029 c -0.774 -2.032 -0.647 -2.006 -0.528 -1.955 c -0.427 -1.906 -0.337 -1.837 -0.263 -1.753 c -0.185 -1.665 -0.124 -1.563 -0.082 -1.453 c -0.034 -1.338 0 -1.218 0.019 -1.094 c 0.635 -1.094 l 0.624 -1.297 0.578 -1.497 0.497 -1.684 c 0.421 -1.857 0.312 -2.015 0.175 -2.146 c 0.039 -2.277 -0.123 -2.379 -0.3 -2.446 c -0.492 -2.519 -0.695 -2.555 -0.9 -2.552 c -1.15 -2.557 -1.397 -2.506 -1.625 -2.404 c -1.829 -2.307 -2.01 -2.169 -2.157 -1.997 c -2.308 -1.821 -2.423 -1.617 -2.497 -1.397 c -2.655 -0.924 -2.655 -0.412 -2.497 0.061 c -2.423 0.281 -2.307 0.485 -2.157 0.661 c -2.01 0.833 -1.829 0.973 -1.625 1.07 c -1.398 1.174 -1.15 1.226 -0.9 1.222 c -0.707 1.223 -0.515 1.196 -0.329 1.14 c -0.159 1.088 0.001 1.006 0.144 0.898 c 0.278 0.793 0.39 0.662 0.473 0.513 c 0.562 0.349 0.615 0.167 0.629 -0.019 c 0 -0.019 l 0 0 l f Q q 1 0 0 1 414.6923 733.5723 cm 0 0 m 0.584 0 l 0.584 -1.328 l 0.662 -1.204 0.771 -1.103 0.9 -1.033 c 1.046 -0.951 1.213 -0.91 1.381 -0.914 c 1.627 -0.9 1.869 -0.979 2.058 -1.137 c 2.234 -1.312 2.325 -1.556 2.305 -1.803 c 2.305 -3.596 l 1.716 -3.596 l 1.716 -1.976 l 1.724 -1.817 1.678 -1.66 1.585 -1.53 c 1.486 -1.43 1.347 -1.379 1.206 -1.392 c 1.114 -1.39 1.024 -1.408 0.94 -1.445 c 0.865 -1.479 0.798 -1.529 0.744 -1.591 c 0.687 -1.656 0.645 -1.73 0.616 -1.812 c 0.586 -1.896 0.571 -1.986 0.571 -2.077 c 0.571 -3.615 l 0 -3.615 l 0 0 l f Q q 1 0 0 1 418.0385 731.1235 cm 0 0 m 0 -0.099 0.014 -0.198 0.043 -0.292 c 0.069 -0.382 0.112 -0.466 0.17 -0.54 c 0.229 -0.611 0.304 -0.669 0.388 -0.709 c 0.486 -0.754 0.594 -0.776 0.702 -0.773 c 0.845 -0.78 0.987 -0.742 1.108 -0.664 c 1.217 -0.582 1.296 -0.468 1.336 -0.337 c 1.881 -0.337 l 1.827 -0.603 1.675 -0.838 1.456 -0.996 c 1.35 -1.073 1.231 -1.131 1.105 -1.169 c 0.971 -1.208 0.831 -1.229 0.691 -1.227 c 0.509 -1.227 0.328 -1.191 0.16 -1.121 c 0.007 -1.063 -0.13 -0.972 -0.244 -0.855 c -0.356 -0.73 -0.44 -0.583 -0.491 -0.422 c -0.548 -0.243 -0.576 -0.056 -0.574 0.133 c -0.575 0.313 -0.545 0.493 -0.486 0.664 c -0.426 0.826 -0.335 0.974 -0.22 1.102 c 0.004 1.375 0.338 1.534 0.691 1.535 c 0.883 1.539 1.072 1.495 1.243 1.408 c 1.402 1.326 1.541 1.209 1.649 1.067 c 1.759 0.922 1.838 0.757 1.883 0.582 c 1.932 0.396 1.945 0.203 1.92 0.013 c 0 0.013 l 0 0 l 1.342 0.377 m 1.335 0.468 1.315 0.557 1.283 0.643 c 1.253 0.724 1.209 0.798 1.153 0.863 c 1.097 0.922 1.03 0.97 0.957 1.004 c 0.874 1.043 0.783 1.063 0.691 1.062 c 0.6 1.062 0.509 1.044 0.425 1.009 c 0.345 0.976 0.273 0.926 0.213 0.863 c 0.153 0.799 0.105 0.724 0.072 0.643 c 0.037 0.559 0.017 0.468 0.014 0.377 c 1.355 0.377 l h f Q q 1 0 0 1 422.1581 731.7051 cm 0 0 m -0.012 0.144 -0.082 0.276 -0.194 0.366 c -0.31 0.452 -0.451 0.495 -0.595 0.489 c -0.675 0.488 -0.755 0.476 -0.831 0.452 c -0.918 0.424 -0.998 0.375 -1.062 0.311 c -1.142 0.229 -1.202 0.131 -1.24 0.024 c -1.29 -0.132 -1.312 -0.296 -1.304 -0.459 c -1.304 -0.569 -1.292 -0.677 -1.267 -0.784 c -1.244 -0.885 -1.202 -0.983 -1.145 -1.07 c -1.09 -1.154 -1.016 -1.224 -0.93 -1.275 c -0.833 -1.33 -0.722 -1.356 -0.611 -1.352 c -0.457 -1.357 -0.307 -1.301 -0.194 -1.195 c -0.078 -1.077 -0.005 -0.922 0.011 -0.757 c 0.587 -0.757 l 0.556 -1.055 0.419 -1.332 0.202 -1.538 c -0.022 -1.721 -0.306 -1.815 -0.595 -1.803 c -0.777 -1.806 -0.958 -1.771 -1.126 -1.7 c -1.293 -1.642 -1.445 -1.547 -1.57 -1.421 c -1.68 -1.297 -1.763 -1.151 -1.814 -0.993 c -1.87 -0.822 -1.898 -0.643 -1.896 -0.462 c -1.898 -0.276 -1.871 -0.091 -1.817 0.087 c -1.766 0.252 -1.682 0.405 -1.57 0.537 c -1.459 0.664 -1.323 0.766 -1.168 0.834 c -0.991 0.914 -0.798 0.955 -0.603 0.954 c -0.457 0.954 -0.311 0.935 -0.17 0.895 c -0.039 0.858 0.084 0.799 0.194 0.72 c 0.302 0.643 0.393 0.543 0.459 0.428 c 0.531 0.298 0.572 0.155 0.582 0.008 c 0 0.008 l 0 0 l f Q q 1 0 0 1 423.2177 733.5723 cm 0 0 m 0.577 0 l 0.577 -2.048 l 1.615 -0.985 l 2.322 -0.985 l 1.323 -1.944 l 2.417 -3.604 l 1.716 -3.604 l 0.919 -2.337 l 0.577 -2.669 l 0.577 -3.604 l 0 -3.604 l h f Q q 1 0 0 1 427.0585 732.5762 cm 0 0 m 0.436 0 l 0.436 0.218 l 0.429 0.352 0.448 0.486 0.488 0.614 c 0.521 0.705 0.577 0.786 0.651 0.85 c 0.717 0.905 0.795 0.943 0.879 0.961 c 0.966 0.979 1.056 0.988 1.145 0.988 c 1.28 0.993 1.416 0.981 1.548 0.954 c 1.548 0.505 l 1.509 0.516 1.469 0.523 1.429 0.528 c 1.379 0.532 1.33 0.532 1.28 0.528 c 1.209 0.53 1.14 0.511 1.081 0.473 c 1.019 0.419 0.987 0.337 0.999 0.255 c 0.999 -0.011 l 1.498 -0.011 l 1.498 -0.441 l 1.009 -0.441 l 1.009 -2.622 l 0.436 -2.622 l 0.436 -0.428 l 0.005 -0.428 l 0.005 0 l 0 0 l f Q q 1 0 0 1 430.1 729.8965 cm 0 0 m -0.191 -0.003 -0.381 0.032 -0.559 0.104 c -0.715 0.167 -0.856 0.264 -0.972 0.388 c -1.091 0.512 -1.181 0.659 -1.238 0.82 c -1.356 1.18 -1.356 1.567 -1.238 1.925 c -1.181 2.087 -1.091 2.234 -0.972 2.358 c -0.856 2.481 -0.715 2.578 -0.559 2.643 c -0.199 2.78 0.198 2.78 0.558 2.643 c 0.714 2.578 0.855 2.481 0.972 2.358 c 1.09 2.234 1.181 2.087 1.237 1.925 c 1.355 1.567 1.355 1.18 1.237 0.82 c 1.181 0.659 1.09 0.512 0.972 0.388 c 0.855 0.266 0.713 0.169 0.558 0.106 c 0.38 0.034 0.191 -0.002 0 0 c 0 0.454 m 0.115 0.451 0.23 0.479 0.332 0.534 c 0.424 0.586 0.502 0.659 0.562 0.746 c 0.624 0.836 0.669 0.936 0.695 1.041 c 0.752 1.26 0.752 1.491 0.695 1.71 c 0.669 1.816 0.625 1.916 0.562 2.005 c 0.502 2.091 0.423 2.163 0.332 2.215 c 0.123 2.323 -0.126 2.323 -0.335 2.215 c -0.427 2.163 -0.505 2.091 -0.566 2.005 c -0.628 1.916 -0.673 1.816 -0.699 1.71 c -0.756 1.491 -0.756 1.26 -0.699 1.041 c -0.672 0.936 -0.627 0.836 -0.566 0.746 c -0.506 0.659 -0.427 0.586 -0.335 0.534 c -0.232 0.478 -0.117 0.451 0 0.454 c f Q q 1 0 0 1 431.8979 732.5762 cm 0 0 m 0.531 0 l 0.531 -0.505 l 0.55 -0.43 0.583 -0.359 0.629 -0.297 c 0.681 -0.229 0.74 -0.167 0.807 -0.114 c 0.877 -0.059 0.956 -0.014 1.039 0.019 c 1.123 0.053 1.213 0.07 1.304 0.069 c 1.52 0.069 l 1.52 -0.486 l 1.395 -0.467 l 1.269 -0.467 l 1.178 -0.468 1.087 -0.488 1.004 -0.526 c 0.917 -0.565 0.839 -0.625 0.778 -0.699 c 0.716 -0.783 0.669 -0.878 0.643 -0.98 c 0.604 -1.104 0.584 -1.233 0.586 -1.362 c 0.586 -2.603 l 0.01 -2.603 l 0.01 0 l 0 0 l f Q q 1 0 0 1 437.3666 729.9683 cm 0 0 m -0.577 0 l -0.577 0.364 l -0.649 0.23 -0.759 0.121 -0.893 0.047 c -1.022 -0.029 -1.169 -0.07 -1.32 -0.072 c -1.595 -0.095 -1.866 0.002 -2.064 0.194 c -2.234 0.413 -2.316 0.687 -2.295 0.964 c -2.295 2.608 l -1.719 2.608 l -1.719 1.014 l -1.735 0.843 -1.689 0.67 -1.588 0.531 c -1.492 0.433 -1.357 0.382 -1.219 0.39 c -1.116 0.387 -1.012 0.406 -0.917 0.446 c -0.84 0.479 -0.772 0.531 -0.72 0.595 c -0.667 0.661 -0.63 0.738 -0.611 0.82 c -0.588 0.911 -0.577 1.003 -0.577 1.097 c -0.577 2.611 l 0 2.611 l 0 0 l f Q q 1 0 0 1 437.9877 732.5762 cm 0 0 m 0.545 0 l 0.545 -0.353 l 0.617 -0.209 0.736 -0.094 0.882 -0.026 c 1.03 0.04 1.19 0.073 1.352 0.072 c 1.535 0.075 1.717 0.038 1.883 -0.037 c 2.031 -0.106 2.161 -0.208 2.263 -0.334 c 2.366 -0.465 2.442 -0.615 2.489 -0.775 c 2.54 -0.948 2.566 -1.127 2.566 -1.307 c 2.566 -1.479 2.542 -1.651 2.497 -1.817 c 2.455 -1.973 2.385 -2.121 2.29 -2.252 c 2.099 -2.522 1.789 -2.682 1.458 -2.68 c 1.369 -2.681 1.28 -2.674 1.193 -2.659 c 1.11 -2.644 1.028 -2.618 0.951 -2.584 c 0.875 -2.552 0.802 -2.509 0.736 -2.457 c 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An)Tj /Span<>> BDC ( )Tj EMC [(integr)-33(a)15(ted ma)-17(gne)-12(t)17.1(o-)]TJ 0.156 Tw -1.796 -1.25 Td [(elec)-16(tr)-31.9(o)-16(chemical dev)-16(ice for t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(r)-33(apid p)25(r)-31.9(of)-28(il)-31(ing of)]TJ /Span<>> BDC ( )Tj EMC [(tumour e)-18(xtr)-33(a)-17(cel)]TJ 0 Tw (-)Tj 0.291 Tw T* [(l)35(ul)-16(ar vesicles fr)-32(om bl)30(o)-16(od pl)-16(as)26(ma. )]TJ /T1_2 1 Tf [(N)18(ature biomedical engineer)-36.9(ing)]TJ /T1_1 1 Tf 0 Tw (. )Tj 0.023 Tw T* [(2021;5\(7\):678\226689. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1038/s41551-021-00752-7)Tj 0 0 0 1 k /GS1 gs -0.055 Tw T* (41.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (A)Tj /Span<>> BDC ( )Tj EMC [(S)15(tud)17(y of)]TJ /Span<>> BDC ( )Tj EMC [(Ima)-17(ging, Bl)30(o)-16(od, and T)35(issue Sam)10(ples t)17(o)]TJ /Span<>> BDC ( )Tj EMC [(Guide T)50(r)-24(ea)15(tment )]TJ 0.023 Tw -1.796 -1.25 Td (of)Tj /Span<>> BDC ( )Tj EMC [(Col)30(on Cancer and R)13(el)-16(a)15(ted L)-31.9(i)-16(ver T)60(umor)-9.9(s. DOI: NCT03432806)]TJ 0.075 Tw T* (42.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Ident)-32(if)-28(ica)15.1(t)-32(ion )0.5(of)]TJ /Span<>> BDC ( )Tj EMC 7.142 0 Td [(New )0.6(Dia)-17(gnost)-32(ic )0.5(P)35.1(r)-32(o)17(tein )0.5(Mar)-23.9(k)10(er)-10(s )0.6(for )0.5(Col)30(or)-23.9(ec)-16(t)15(al )]TJ 0.023 Tw -8.938 -1.25 Td [(Cancer \(EX)17.1(OSC)13(OL01\). DOI: NCT04394572)]TJ 0.311 Tw T* (43.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Contents of)Tj /Span<>> BDC ( )Tj EMC [(Cir)-32(cul)-16(a)15(t)-32(ing E)35.1(xtr)-33(a)-17(cell)35(ul)-16(ar V)30(esicles: Biomar)-23.9(k)10(er)-10(s in )]TJ 0.023 Tw -1.796 -1.25 Td [(Col)30(or)-23.9(ec)-16(t)15(al Cancer P)40(a)15(t)-31.9(ients \(E)35(x)10(oCol)30(on\). DOI: NCT04523389)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 0 Tw 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\033\030\031\030\217\n)-20.9(\035\210\217\241\003 \013\032)50(\n)42(\032\210\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj /T1_3 1 Tf 25 0 0 25 505.4397 56.0378 Tm (105)Tj ET endstream endobj 1645 0 obj <>/Border[0 0 0]/H/N/Rect[173.262 738.512 263.622 729.056]/Subtype/Link/Type/Annot>> endobj 1646 0 obj <>/Border[0 0 0]/H/N/Rect[185.127 708.512 261.847 699.056]/Subtype/Link/Type/Annot>> endobj 1647 0 obj <>/Border[0 0 0]/H/N/Rect[233.71 678.512 263.622 669.056]/Subtype/Link/Type/Annot>> endobj 1648 0 obj <>/Border[0 0 0]/H/N/Rect[42.5197 668.512 84.9834 659.216]/Subtype/Link/Type/Annot>> endobj 1649 0 obj <>/Border[0 0 0]/H/N/Rect[120.228 638.512 221.723 629.216]/Subtype/Link/Type/Annot>> endobj 1650 0 obj <>/Border[0 0 0]/H/N/Rect[442.151 738.512 496.063 729.056]/Subtype/Link/Type/Annot>> endobj 1651 0 obj <>/Border[0 0 0]/H/N/Rect[274.961 728.512 331.696 719.216]/Subtype/Link/Type/Annot>> endobj 1652 0 obj <>/Border[0 0 0]/H/N/Rect[357.381 688.512 454.852 679.216]/Subtype/Link/Type/Annot>> endobj 1660 0 obj <> endobj 1659 0 obj <> endobj 1658 0 obj <> endobj 1657 0 obj <> endobj 1656 0 obj <> endobj 1655 0 obj <> endobj 1654 0 obj <> endobj 1653 0 obj <> endobj 1641 0 obj [1661 0 R 1662 0 R 1663 0 R 1664 0 R 1665 0 R 1666 0 R 1667 0 R 1668 0 R 1669 0 R 1670 0 R 1671 0 R 1672 0 R 1673 0 R 1674 0 R 1675 0 R 1676 0 R 1677 0 R 1678 0 R 1679 0 R 1680 0 R 1681 0 R 1682 0 R 1683 0 R 1684 0 R 1685 0 R 1686 0 R 1687 0 R 1688 0 R 1689 0 R 1690 0 R 1691 0 R 1692 0 R 1693 0 R 1694 0 R 1695 0 R 1696 0 R 1697 0 R 1698 0 R 1699 0 R 1700 0 R 1701 0 R] endobj 1642 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.023 Tw 8 0 0 8 70.8661 731.2159 Tm [(2023;163:114786. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1016/j.biopha.2023.114786)Tj 0 0 0 1 k /GS1 gs 0.305 Tw 0 -1.25 TD (3.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (Hanna)Tj /Span<>> BDC ( )Tj EMC [(M, )0.5(De)-11(y)]TJ /Span<>> BDC ( )Tj EMC [(N, )0.5(G)20(r)-33(ad)17(y)]TJ /Span<>> BDC ( )Tj EMC [(WM. )0.5(Emer)-32(ging T)40(ests )0.5(for N)-14(oninv)-14.9(asi)-16(ve )]TJ -0.07 Tw -1.296 -1.25 Td [(Col)30(or)-24(ec)-15.9(t)15(al Cancer S)-24(cr)-24(eening. )]TJ /T1_1 1 Tf (Clinical Gastroenterology and Hepatology)Tj /T1_0 1 Tf 0 Tw (. )Tj 0.023 Tw T* [(2023;21\(3\):604\226616. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1016/j.cgh.2022.12.008)Tj 0 0 0 1 k /GS1 gs 0.19 Tw T* (4.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Mannucc)-24(i)]TJ /Span<>> BDC ( )Tj EMC (A, Goel)Tj /Span<>> BDC ( )Tj EMC [(A. S)15(t)17(o)-16(ol and bl)30(o)-16(od biomar)-24(k)10(er)-9.9(s for col)30.1(or)-24(ec)-16(t)15(al )]TJ 0.127 Tw -1.296 -1.25 Td [(cancer mana)-17(gement: an)]TJ /Span<>> BDC ( )Tj EMC [(upd)42(a)15(te on scr)-23.9(eening and disease moni)-23.9(t)17(or)]TJ 0 Tw 27.286 0 Td (-)Tj -27.286 -1.25 Td (ing. )Tj /T1_1 1 Tf 0.237 Tw 2.064 0 Td (Molecular Cancer)Tj /T1_0 1 Tf [(. 2024;23\(1\):259. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1186/s12943-024-)Tj -2.064 -1.25 Td (02174-w)Tj 0 0 0 1 k /GS1 gs 0.01 Tc 0.386 Tw T* (5.)Tj /Span<>> BDC ( )Tj EMC 1.327 0 Td (\202\b\n\026\035\021\007\017\027\024\r\026)Tj /Span<>> BDC ( )Tj EMC 6.6 0 Td [(\214.\214., )0.6(\202\r\007\017\036\027\022\024)]TJ /Span<>> BDC ( )Tj EMC 7.314 0 Td [(\210.\200., )0.6(\224\017\030\024\021\026)]TJ /Span<>> BDC ( )Tj EMC 6.08 0 Td [(\200.\207., )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC 3.715 0 Td [(\f\024\026\r\021.)10( )]TJ 0.381 Tw -25.036 -1.25 Td (\207\017\024\n\026\030\022\036\030\t \r)Tj /Span<>> BDC ( )Tj EMC (\007\017\026\020\027\024\f\021\017\022\036 \022\024\035\024\030\036\022\021\ \026\035\034\027\024\020\024 \030\026\022\026. )Tj /T1_1 1 Tf -0.01 Tw [(\214\016\b\022\007\022\020\037)10( )]TJ 0 Tc 0.105 Tw T* (\022)Tj /Span<>> BDC ( )Tj EMC (\220\021\034\027\034\013\022\030)Tj /T1_0 1 Tf [(. 2018. / Akhmal)56.1(tdinov)-15(a)]TJ /Span<>> BDC ( )Tj EMC [(L.L., A)15(v)12(dienko)]TJ /Span<>> BDC ( )Tj EMC [(O.V., S)-16(ir)-31.9(o)17(t)15(a)]TJ /Span<>> BDC ( )Tj EMC (V.B., )Tj 0.038 Tw T* [(e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Biomar)-24(k)10(er)-9.9(s in t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(dia)-17(gnosis of)]TJ /Span<>> BDC ( )Tj EMC [(col)30(or)-23.9(ec)-16(t)15(al cancer. )]TJ /T1_1 1 Tf (Medicine and )Tj 0 Tw T* (Ecology)Tj /T1_0 1 Tf 0.023 Tw (. 2018. \(In Russ.\))Tj -0.008 Tw T* (6.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (\025\024\f\026\030\036\r\026)Tj /Span<>> BDC ( )Tj EMC 4.089 0 Td [(\215.\200., )0.5(\025\024\027\036\r)]TJ /Span<>> BDC ( )Tj EMC 4.884 0 Td [(\217.\202., )0.5(\224\017\r\026\022\024\r\026)]TJ /Span<>> BDC ( )Tj EMC 6.111 0 Td [(\214.\200., )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 2.873 0 Td [(\f\024\026\r\021. )0.5(\210\027\022\024\n\026\030\022\036\030\t )]TJ 0.162 Tw -19.253 -1.25 Td (\r)Tj /Span<>> BDC ( )Tj EMC (\007\017\026\020\027\024\f\021\017\022\036, \023\030\024\020\027\024\036\ \017)Tj /Span<>> BDC ( )Tj EMC (\r\t\002\024\030\036 \n\036\021\024\007\026 \035\036\004\036\027\017\016\ \022\024\035\024\030\036\022\021\026\035\034)Tj 0 Tw (-)Tj 0.253 Tw T* (\027\024\020\024 \030\026\022\026. )Tj /T1_1 1 Tf (\207\034\036\033\016\006\016\020\020\032\016 \f\033\034\025\027\016\006\032\ \020\037\023\021\022 \022)Tj /Span<>> BDC ( )Tj EMC (\034\025\033\037\031\034\036\037\020\022\030)Tj /T1_0 1 Tf (. 2022. )Tj 0.133 Tw T* [(/ K)25(osar)-24(ev)-15(a)]TJ /Span<>> BDC ( )Tj EMC [(P.V., K)25(onev)]TJ /Span<>> BDC ( )Tj EMC [(R.A., S)-15.9(i)-16(v)-15(akov)-15(a)]TJ /Span<>> BDC ( )Tj EMC [(L.V., e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. T)60(umor mar)-23.9(k)10(er)-10(s in )]TJ 0.125 Tw T* [(dia)-17(gnosis, p)25(r)-32(o)-16(gnosis and choice of)]TJ /Span<>> BDC ( )Tj EMC [(tr)-24(ea)15(tment me)-12(t)-13(hod of)]TJ /Span<>> BDC ( )Tj EMC [(col)30(or)-23.9(ec)-16(t)15(al )]TJ 0 Tw T* (cancer. )Tj /T1_1 1 Tf 0.023 Tw 3.19 0 Td [(Moder)-13.9(n Problems of)]TJ /Span<>> BDC ( )Tj EMC (Science and Education)Tj /T1_0 1 Tf (. 2022. \(In Russ.\).)Tj 0.009 Tc 0.352 Tw -3.19 -1.25 Td (7.)Tj /Span<>> BDC ( )Tj EMC 1.324 0 Td (\216\026\027\036\r\017\004)Tj /Span<>> BDC ( )Tj EMC (\204.\212., \216\026\024\r)Tj /Span<>> BDC ( )Tj EMC (\202.\200., \216\030\t\022\024\r)Tj /Span<>> BDC ( )Tj EMC (\206.\203., \017)Tj /Span<>> BDC ( )Tj EMC [(\f\024\026\r\021. \205\026\022\021\024\030\t)9.1( )]TJ 0 Tc 0.091 Tw -1.324 -1.25 Td (\030\017\f\022\026 \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\235\017\035\026\022\021\017\022\026 \022\024\035\024\030\036\ \022\021\026\035\034\027\024\020\024 \030\026\022\026. )Tj /T1_1 1 Tf 0 Tw (\t\033\034\017\022\027\037\021\035\022\005\016\024\021\037\030 )Tj T* (\006\016\b\022\007\022\020\037)Tj /T1_0 1 Tf 0.35 Tw (. 2019;22\(3\):107)Tj /Span<>> BDC (-)Tj EMC [(111. / Khanev)-16.2(ich)]TJ /Span<>> BDC ( )Tj EMC [(M.D., Kha)-24.2(zov)]TJ /Span<>> BDC ( )Tj EMC (A.V., )Tj 0.029 Tw T* [(Khr)-24(ykov)]TJ /Span<>> BDC ( )Tj EMC [(G.N., e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. R)-24(isk f)16(a)-17(c)-16(t)17(or)-9.9(s and p)25(r)-24(event)-32(ion of)]TJ /Span<>> BDC ( )Tj EMC [(col)30(or)-24(ec)-16(t)15(al cancer. )]TJ /T1_1 1 Tf 0.023 Tw T* [(Prev)13(entiv)13(e medicine)]TJ /T1_0 1 Tf (. 2019;22\(3\):107)Tj /Span<>> BDC (-)Tj EMC (111. \(In Russ.\).)Tj -0.02 Tw T* (8.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (\025\026\023\030\017\027)Tj /Span<>> BDC ( )Tj EMC (\202.\212., \224\021\026\030\017\027\f\022\017\005)Tj /Span<>> BDC ( )Tj EMC (\200.\200., \221\024\b\026\007\024\r\026)Tj /Span<>> BDC ( )Tj EMC (\202.\210. \003\035\024\022\026\004\036\f\021\r\036\027\027\t\036 )Tj 0.076 Tw -1.296 -1.25 Td (\027\024\r\024\024\002\030\026\024\r\026\027\017\016 \r)Tj /Span<>> BDC ( )Tj EMC (\217\024\f\f\017\017 \r)Tj /Span<>> BDC ( )Tj EMC (2023 \020\024\007\031 \(\026\002\024\035\036\r\026\036\n\024\f\021\034 \ \017)Tj /Span<>> BDC ( )Tj EMC (\f\n\036\030\021)Tj 0 Tw (-)Tj -0.034 Tw T* [(\027\024\f\021\034\). \204\024\f\022\r\026, 2024. / K)-16(ap)25.1(r)-37(in)]TJ /Span<>> BDC ( )Tj EMC [(A.D., S)15(t)15(ar)-37(insk)-32(y)]TJ /Span<>> BDC ( )Tj EMC [(V.V., S)-16(hokhzad)-16(ov)-15(a)]TJ /Span<>> BDC ( )Tj EMC (A.O. )Tj 0.142 Tw T* [(Mal)-31(ignant neopl)-16(as)26(ms in Russia in 2023 \(mor)-24(bidi)-24(t)-9.9(y and mor)-22(t)15(al)-31(i)-23.9(t)-10(y\). )]TJ 0.023 Tw T* [(M)-24(osco)-14(w, 2024. \(In Russ.\).)]TJ 0.143 Tw T* (9.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (Gao)Tj /Span<>> BDC ( )Tj EMC 1.876 0 Td [(Y, )0.5(Qin)]TJ /Span<>> BDC ( )Tj EMC 2.771 0 Td [(Y, )0.5(W)12(an)]TJ /Span<>> BDC ( )Tj EMC 3.091 0 Td [(C, )0.5(e)-12(t)]TJ /Span<>> BDC ( )Tj EMC 2.234 0 Td [(al. )0.5(Small )0.5(E)35(xtr)-32.9(a)-17(cell)35(ul)-16(ar )0.5(V)30.1(esicles: )0.5(A)]TJ /Span<>> BDC ( )Tj EMC 14.097 0 Td [(N)-14(ovel )]TJ 0.023 Tw -25.365 -1.25 Td [(A)15(venue for Cancer Mana)-17(gement. )]TJ /T1_1 1 Tf [(F)27(rontiers in Oncology)]TJ /T1_0 1 Tf (. 2021.)Tj 0.089 Tw T* (10.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Na)-24(zar)-31.9(ov)-15(a)]TJ /Span<>> BDC ( )Tj EMC [(I, S)-15.9(l)35(yusar)-24(enko)]TJ /Span<>> BDC ( )Tj EMC [(M, S)-16(idina)]TJ /Span<>> BDC ( )Tj EMC [(E, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Ev)-15(al)35(ua)15(t)-32(ion of)]TJ /Span<>> BDC ( )Tj EMC [(Col)30(on-)]TJ 0.141 Tw -1.796 -1.25 Td [(Spec)-24(if)-28(ic Pl)-16(as)26(ma Nanovesicles as New Mar)-23.9(k)10(er)-10(s of)]TJ /Span<>> BDC ( )Tj EMC [(Col)30(or)-23.9(ec)-16(t)15(al Cancer. )]TJ /T1_1 1 Tf 0 Tw T* (Cancers)Tj /T1_0 1 Tf 0.023 Tw [(. 2021;13\(15\):3905. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw [(10.3390/cancer)-9.9(s13153905)]TJ 0 0 0 1 k /GS1 gs 0.011 Tc 0.395 Tw T* (11.)Tj /Span<>> BDC ( )Tj EMC 1.839 0 Td (\203\026\026\030\024\r\026)Tj /Span<>> BDC ( )Tj EMC (\236.\200., \203\017\022\017\235\024\030\024\r\026)Tj /Span<>> BDC ( )Tj EMC (\203.\224., \224\017\007\017\027\026)Tj /Span<>> BDC ( )Tj EMC (\213.\236., \017)Tj /Span<>> BDC ( )Tj EMC [(\f\024\026\r\021.)11.1( )]TJ 0.398 Tw -1.839 -1.25 Td (\200\024\n\024\032\027\024\f\021\017 \007\017\026\020\027\024\f\021\017\ \022\017 \022\024\035\024\030\036\022\021\026\035\034\027\024\020\024 \030\ \026\022\026 \f)Tj /Span<>> BDC ( )Tj EMC [(\023\024\n\024\013\034\033)11.1( )]TJ 0.02 Tc 0.713 Tw T* [(\007\036\021\036\022\006\017\017 \021\022\026\027\036-\f\023\036\006\017\ \235\017\004\027\t\b \r\027\036\022\035\036\021\024\004\027\t\b \027\026\ \027\024-\r\026\017\022\031\035.)20( )]TJ /T1_1 1 Tf 0 Tc 0 Tw T* (\r\034\027\034\f\033\034\021\035\034\027\034\013\022\030)Tj /T1_0 1 Tf 0.321 Tw [(. 2019;19\(4\):32\22656. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.33878/2073-7556-)Tj T* (2020-19-4-32-56)Tj 0 0 0 1 k /GS1 gs 0.088 Tw [( )0.6(/ )0.5(Na)-24(zar)-31.9(ov)-15(a)]TJ /Span<>> BDC ( )Tj EMC 12.039 0 Td [(I.V., )0.6(Nik)-16(ifor)-32(ov)-14.9(a)]TJ /Span<>> BDC ( )Tj EMC 6.486 0 Td [(N.S., )0.6(S)-16(idina)]TJ /Span<>> BDC ( )Tj EMC 4.989 0 Td [(E.I., )0.6(e)-12(t)]TJ /Span<>> BDC ( )Tj EMC 3.106 0 Td (al. )Tj 0.01 Tc 0.358 Tw -26.62 -1.25 Td [(Col)30.5(or)-23.5(ec)-15.6(t)15.4(a)0.5(l C)0.5(anc)0.5(er Dia)-16.6(g)0.5(nos)0.5(t)-31.6(ics)0.5( V)-14.6(i)0.5(a D)0.5(e)-11.6(te)0.5(c)-15.6(t)-31.6(i)0.5(on of)]TJ /Span<>> BDC ( )Tj EMC [(T)35.4(is)0.5(sue-)0.5(Spec)-23.5(if)-27.6(i)0.5(c)10( )]TJ 0 Tc 0.098 Tw T* [(E)35(xtr)-33(a)-17(cell)35.1(ul)-16(ar Nano-V)30(esicles. )]TJ /T1_1 1 Tf 0 Tw [(K)18(olop)46(roktologia)]TJ /T1_0 1 Tf 0.098 Tw (. 2019;19\(4\):32\22656. \(In )Tj 0.023 Tw T* [(Russ.\). d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.33878/2073-7556-2020-19-4-32-56)Tj 0 0 0 1 k /GS1 gs -0.097 Tw T* (12.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(R\366t)-13(hl)-30.9(isber)-32(ger)]TJ /Span<>> BDC ( )Tj EMC (P, Hollenstein)Tj /Span<>> BDC ( )Tj EMC [(M. Apt)15(amer chemistr)-23.9(y. )]TJ /T1_1 1 Tf [(Adv)16(anced Drug )]TJ 0.023 Tw -1.796 -1.25 Td [(Deliv)13(er)-43(y R)21(evie)10(ws)]TJ /T1_0 1 Tf [(. 2018;134:3\22621. d)-15.9(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1016/j.addr.2018.04.007)Tj 0 0 0 1 k /GS1 gs 0.283 Tw T* (13.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Ell)-31(ing)17.1(t)17(on)]TJ /Span<>> BDC ( )Tj EMC [(A.D., Szost)15(ak)]TJ /Span<>> BDC ( )Tj EMC [(J.W. In v)-15.9(i)-24(tr)-32(o selec)-16(t)-32(ion of)]TJ /Span<>> BDC ( )Tj EMC [(RN)13(A mol)]TJ 0 Tw (-)Tj 0.035 Tw -1.796 -1.25 Td [(ecules t)-13(ha)15.1(t bind spec)-24(if)-28(ic l)-31(igands. )]TJ /T1_1 1 Tf 0 Tw [(N)18(ature)]TJ /T1_0 1 Tf 0.035 Tw (. 1990;346\(6287\):818\226822. )Tj 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1038/346818a0)Tj 0 0 0 1 k /GS1 gs 0.003 Tc 0.349 Tw -1.847 -1.25 Td [(1)0.5(4.)]TJ /Span<>> BDC 1.304 0 Td ( )Tj EMC 0.503 0 Td [(L)-31.5(i)0.5( W-)0.5(M)0.5(, B)0.5(i)0.5(ng)]TJ /Span<>> BDC 5.702 0 Td ( )Tj EMC [(T)0.5(, W)22.5(e)0.5(i J)0.5(-)0.5(Y)0.5(, e)-11.5(t)]TJ /Span<>> BDC 6.742 0 Td ( )Tj EMC [(a)0.5(l.)0.5( C)0.5(e)0.5(ll)0.5(-)0.5(SE)0.5(L)0.5(E)0.5(X)0.5(-b)0.5(a)0.5(s)0.5(ed)0.5( s)0.5(el)0.5(e)0.5(c)-15.5(t)-31.6(i)0.5(o)0.5(n)3( )]TJ 0 Tc 0.046 Tw -14.25 -1.25 Td (of)Tj /Span<>> BDC ( )Tj EMC [(apt)15.1(amer)-10(s t)-13(ha)15(t r)-24(eco)-16(gnize dist)-32(inc)-16(t t)15(ar)-32(ge)-12(ts on me)-12(t)15(ast)15(a)15(t)-32(ic col)30(or)-24(ec)-16(t)15(al )]TJ 0.071 Tw T* (cancer cells. )Tj /T1_1 1 Tf 0 Tw [(Biomater)-37(ials)]TJ /T1_0 1 Tf 0.071 Tw [(. 2014;35\(25\):6998\2267007. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1016/j.)Tj T* [(bioma)15(ter)-36.9(ials.2014.04.112)]TJ 0 0 0 1 k /GS1 gs -0.008 Tw T* (15.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Sef)16(ah)]TJ /Span<>> BDC ( )Tj EMC (K, Meng)Tj /Span<>> BDC ( )Tj EMC [(L, L)35(opez-Col)30(on)]TJ /Span<>> BDC ( )Tj EMC [(D, e)-11.9(t)]TJ /Span<>> BDC ( )Tj EMC [(al. DN)13(A Apt)15(amer)-10(s as M)-24(olecul)-16(ar )]TJ 0.156 Tw -1.796 -1.25 Td [(P)35(r)-32(obes for Col)30.1(or)-24(ec)-16(t)15(al Cancer S)15.1(tud)17(y. )]TJ /T1_1 1 Tf (PLoS ONE)Tj /T1_0 1 Tf (. 2010;5\(12\):e14269. )Tj 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td [(10.1371/jour)-14.9(nal.pone.0014269)]TJ 0 0 0 1 k /GS1 gs 0.098 Tw -1.847 -1.25 Td (16.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Maimai)-24(t)-31.9(iyiming)]TJ /Span<>> BDC ( )Tj EMC [(Y, Y)50(ang)]TJ /Span<>> BDC ( )Tj EMC [(C, W)12(ang)]TJ /Span<>> BDC ( )Tj EMC [(Y, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Selec)-16(t)-32(ion and char)-32.9(a)-17.1(c)]TJ 0 Tw (-)Tj -0.009 Tw -1.796 -1.25 Td [(ter)-37(iza)15.1(t)-32(ion of)]TJ /Span<>> BDC ( )Tj EMC [(novel DN)13(A apt)15.1(amer a)-17(gainst col)30(or)-24(ec)-15.9(t)15(al car)-31.9(c)-24(inoma Ca)-17(co)]TJ /Span<>> BDC (-)Tj EMC (2 )Tj 0 Tw T* (cells. )Tj /T1_1 1 Tf 0.066 Tw 2.406 0 Td [(Bio)13(technology and Applied )0.5(Biochemistr)-43(y)]TJ /T1_0 1 Tf (. 2019;66\(3\):412\226418. )Tj 0 Tw -2.406 -1.25 Td [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1002/bab.1737)Tj 0 0 0 1 k /GS1 gs -0.022 Tw -1.847 -1.25 Td (17.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Zhu)Tj /Span<>> BDC ( )Tj EMC [(C, L)-31.9(i)]TJ /Span<>> BDC ( )Tj EMC [(L, W)12(ang)]TJ /Span<>> BDC ( )Tj EMC [(Z, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. R)13(ecent ad)-17(v)-14.9(ances of)]TJ /Span<>> BDC ( )Tj EMC [(apt)15(asensor)-9.9(s for e)-18(x)10(o)]TJ 0 Tw (-)Tj 0.205 Tw -1.796 -1.25 Td [(somes de)-12(tec)-16(t)-32(ion. )]TJ /T1_1 1 Tf [(Biosensors )0.5(and Bioelectronics)]TJ /T1_0 1 Tf (. 2020;160:112213. )Tj 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1016/j.bios.2020.112213)Tj 0 0 0 1 k /GS1 gs 0.01 Tc 0.384 Tw -1.847 -1.25 Td (18.)Tj /Span<>> BDC ( )Tj EMC 1.837 0 Td (\025\026\006\031\002\026)Tj /Span<>> BDC ( )Tj EMC (\025.\213., \025\030\026\n\t\027\017\027)Tj /Span<>> BDC ( )Tj EMC (\214.\202., \224\035\033\f\026\030\036\027\022\024)Tj /Span<>> BDC ( )Tj EMC (\204.\202., \017)Tj /Span<>> BDC ( )Tj EMC [(\f\024\026\r\021.)10.1( )]TJ 0.022 Tc 0.8 Tw -1.837 -1.25 Td [(\212\017\026\020\027\024\f\021\017\004\036\f\022\017\005 \023\024\021\036\ \027\006\017\026\035 CD30\(+\)-\027\026\027\024\r\036\017\022\031\035 \023\ \035\026\n\t)22( )]TJ 0.012 Tc 0.45 Tw T* (\023\030\017)Tj /Span<>> BDC ( )Tj EMC (\035\017\n\235\024\n\036 \216\024\007\032\022\017\027\026. )Tj /T1_1 1 Tf -0.012 Tw (\240\020\021\034\013\016\006\037\035\034\027\034\013\022\030)Tj /T1_0 1 Tf 0.45 Tw (. 2023;18\(4\):145\226)Tj 0 Tc 0.28 Tw T* [(155. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.17650/1818-8346-2023-18-4-145-155)Tj 0 0 0 1 k /GS1 gs 0.28 Tw [( / K)-16(a)15(tsuba)]TJ /Span<>> BDC ( )Tj EMC (KE, )Tj 0.001 Tw T* [(Kr)-33(amynin)]TJ /Span<>> BDC ( )Tj EMC 4.046 0 Td [(L)-35(A, )0.5(S)-16(l)35(yusar)-24(enko)]TJ /Span<>> BDC ( )Tj EMC 6.475 0 Td [(MA, )0.5(e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. )0.5(Dia)-17(gnost)-32(ic po)17(tent)-31.9(ial of)]TJ /Span<>> BDC ( )Tj EMC 13.502 0 Td (CD30\(+\)-)Tj 0.011 Tc 0.401 Tw 5.032 81.25 Td [(pl)-15.7(as)26.2(ma nanovesicles in Hodgk)-15.8(in\246s l)35.2(ym)10.2(phoma. )]TJ /T1_1 1 Tf -0.011 Tw (Oncohematology)Tj /T1_0 1 Tf 0 Tc 0 Tw (. )Tj 0.268 Tw T* [(2023;18\(4\):145\226155. \(In Russ.\). d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.17650/1818-8346-2023-)Tj T* (18-4-145-155)Tj 0 0 0 1 k /GS1 gs 0.051 Tw T* (19.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(S)-16(l)35(yusar)-23.9(enko)]TJ /Span<>> BDC ( )Tj EMC [(M, S)-16(hal)-15.9(aev)]TJ /Span<>> BDC ( )Tj EMC [(S, V)25(al)-30.9(i)-24(t)17(ov)-15(a)]TJ /Span<>> BDC ( )Tj EMC [(A, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. A)10(uNP Apt)15(asensor for )]TJ 0.298 Tw -1.796 -1.25 Td [(Hodgk)-16(in L)70(ym)10(phoma M)-24(oni)-24(t)17(or)-36.9(ing. )]TJ /T1_1 1 Tf 0 Tw (Biosensors)Tj /T1_0 1 Tf 0.298 Tw [(. 2022. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.3390/)Tj T* (bios12010023)Tj 0 0 0 1 k /GS1 gs 0.094 Tw T* (20.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Z)10(abegina)]TJ /Span<>> BDC ( )Tj EMC [(L, Zy)22(a)15(tchin)]TJ /Span<>> BDC ( )Tj EMC [(I, Knia)-23.9(zev)-15(a)]TJ /Span<>> BDC ( )Tj EMC [(M, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Dia)-17(gnosis of)]TJ /Span<>> BDC ( )Tj EMC [(P)35(r)-32(ost)15(a)15(te )]TJ 0.011 Tc 0.411 Tw -1.796 -1.25 Td [(Cancer t)-13(hr)-32.1(ough t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(Mul)56(t)-32.1(i-L)-32(igand Binding of)]TJ /Span<>> BDC ( )Tj EMC [(P)34.9(r)-32(ost)15(a)14.9(te-Der)-37.1(i)-16(ved)11( )]TJ 0 Tc 0.234 Tw T* [(E)35(xtr)-33(a)-16.9(cell)35(ul)-16(ar V)30(esicles and miRN)13(A Anal)35(y)-13(sis. )]TJ /T1_1 1 Tf 0 Tw (Life)Tj /T1_0 1 Tf 0.234 Tw (. 2023;13\(4\):1\22615. )Tj 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td [(10.3390/l)-31(ife13040885)]TJ 0 0 0 1 k /GS1 gs -0.041 Tw -1.847 -1.25 Td (21.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(T)60(ur)-24(k)10(ev)-15.9(ich)]TJ /Span<>> BDC ( )Tj EMC [(J, S)15(tevenson)]TJ /Span<>> BDC ( )Tj EMC [(PC, Hill)-30.9(ier)]TJ /Span<>> BDC ( )Tj EMC (J. A)Tj /Span<>> BDC ( )Tj EMC [(stud)17(y of)]TJ /Span<>> BDC ( )Tj EMC [(t)-13(he nuclea)15.1(t)-32(ion and )]TJ -0.012 Tw -1.796 -1.25 Td [(gr)-32(o)-14(w)-23.9(t)-13(h p)25(r)-32(o)-16(cesses in t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(synt)-13(hesis of)]TJ /Span<>> BDC ( )Tj EMC [(coll)30(oid)42(al gold. )]TJ /T1_1 1 Tf (Discussions of)Tj /Span<>> BDC ( )Tj EMC (the )Tj 0.023 Tw T* [(F)15(arad)26(ay Society)]TJ /T1_0 1 Tf [(. 1951;55\(03\):580\226584. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1039/df9511100055)Tj 0 0 0 1 k /GS1 gs 0.28 Tw T* (22.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(S)-16(l)35(yusar)-23.9(enko)]TJ /Span<>> BDC ( )Tj EMC [(M, Nik)-16(ifor)-31.9(ov)-15(a)]TJ /Span<>> BDC ( )Tj EMC [(N, S)-16(idina)]TJ /Span<>> BDC ( )Tj EMC [(E, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. F)10(or)-15.9(ma)15(t)-32(ion and )]TJ 0.295 Tw -1.796 -1.25 Td [(ev)-15(al)35(ua)15(t)-32(ion of)]TJ /Span<>> BDC ( )Tj EMC (a)Tj /Span<>> BDC ( )Tj EMC [(t)-32(w)-13.9(o-phase pol)35(ymer sy)-13(stem in human pl)-16(as)26(ma as )]TJ 0.221 Tw T* (a)Tj /Span<>> BDC ( )Tj EMC [(me)-12(t)-13(hod for e)-18(xtr)-32.9(a)-17(cell)35(ul)-16(ar nanovesicle isol)-16(a)15.1(t)-32(ion. )]TJ /T1_1 1 Tf 0 Tw [(P)15(olymers)]TJ /T1_0 1 Tf 0.221 Tw (. 2021. )Tj 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td [(10.3390/pol)35(ym13030458)]TJ 0 0 0 1 k /GS1 gs 0.069 Tw -1.847 -1.25 Td (23.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(W)-16(illms)]TJ /Span<>> BDC ( )Tj EMC (E, Caba\361as)Tj /Span<>> BDC ( )Tj EMC (C, M\344ger)Tj /Span<>> BDC ( )Tj EMC [(I, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. E)35(xtr)-32.9(a)-17(cell)35(ul)-16(ar vesicle he)-11.9(ter)-32(o)]TJ 0 Tw (-)Tj -0.005 Tw -1.796 -1.25 Td [(genei)-24(t)-9.9(y: Subpopul)-16(a)15(t)-32(ions, isol)-15.9(a)15(t)-32(ion techniques, and di)-16(ver)-10(se func)-16(t)-31.9(ions )]TJ 0.037 Tw T* [(in cancer p)25(r)-32(o)-16(gr)-23.9(ession. )]TJ /T1_1 1 Tf [(F)27(rontiers in Immunology)]TJ /T1_0 1 Tf [(. 2018. d)-15.9(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.3389/)Tj T* [(f)-28(immu.2018.00738)]TJ 0 0 0 1 k /GS1 gs 0.27 Tw T* (24.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Y)50(aha)15(y)22(a)]TJ /Span<>> BDC ( )Tj EMC [(ML, Z)10(ak)-17(ar)-36.9(ia)]TJ /Span<>> BDC ( )Tj EMC [(ND, N)-14(o)-16(or)-24(din)]TJ /Span<>> BDC ( )Tj EMC [(R, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. 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A)15(TP-enhanced per)-32(o)14(xid)42(ase-)]TJ 0.117 Tw -1.796 -1.25 Td [(l)-31(ik)10(e )0.6(a)-17(c)-16(t)-32(i)-16(v)-16(i)-24(t)-9.9(y )0.5(of)]TJ /Span<>> BDC ( )Tj EMC 6.518 0 Td [(gold )0.5(nanop)32(ar)-21.9(t)-32(icles. )]TJ /T1_1 1 Tf 8.24 0 Td [(Jour)-13.9(nal )0.5(of)]TJ /Span<>> BDC ( )Tj EMC 4.474 0 Td [(Colloid )0.6(and )0.5(Inter)-33.9(face )]TJ 0 Tw -19.232 -1.25 Td (Science)Tj /T1_0 1 Tf 0.023 Tw [(. 2015;456:100\226107. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw [(10.1016/j.jc)-23.9(is.2015.06.015)]TJ 0 0 0 1 k /GS1 gs 0.215 Tw T* (26.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Cha)Tj /Span<>> BDC ( )Tj EMC (BS, Jang)Tj /Span<>> BDC ( )Tj EMC [(Y)15(J, L)35(ee)]TJ /Span<>> BDC ( )Tj EMC [(ES, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. 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[(K)12.8(a)-4.9(t)-29.1(s)11.2(u)6.4(ba)]TJ /T1_1 1 Tf -0.007 Tc 0.683 Tw T* [(St)-34.7(a)-15.4(t)-44.4(i)-4.3(s)-27(t)-44.4(i)-1.8(c)-18.8(a)-8.5(l)-7( p)-10.8(r)-13(o)-14(c)-6.8(e)-20.3(s)-19.8(s)-23.5(in)-8.8(g)2(:)]TJ /T1_2 1 Tf -0.005 Tc 0.681 Tw 9.765 0 Td [( E)15.6(k)10.8(a)-9.9(t)-2.2(e)-6.7(r)-40.3(i)3.4(na)]TJ /Span<>> BDC 4.64 0 Td ( )Tj EMC [(Y)34.3(a.)-5( K)7.8(a)-9.5(d)-3.1(a)-5.7(n)-1.2(t)-34.2(se)-8.9(v)5.7(a)-18.9(,)-5( )]TJ 0 Tc 0 Tw -14.404 -1.218 Td [(K)13.3(on)8.1(s)-10.7(t)2.3(a)-0.8(n)3.8(t)-25.2(i)8.5(n)]TJ /Span<>> BDC ( )Tj EMC [(E)19.8(.)]TJ /Span<>> BDC ( )Tj EMC [(K)12.8(a)-4.9(t)-29.1(s)11.2(u)6.4(ba)-13.9(, T)49.7(a)-4.9(t)-25.2(i)5.9(a)-0.8(n)4.8(a)]TJ /Span<>> BDC ( )Tj EMC [(V)53.2(.)]TJ /Span<>> BDC ( )Tj EMC [(S)15.3(h)4.8(ar)2.4(on)1.9(o)-0.6(v)10.9(a)]TJ /T1_1 1 Tf 0.926 Tw T* [(W)3.1(r)-48(i)-6(t)-37.4(i)7.2(n)-1.9(g o)-2.2(f)]TJ /Span<>> BDC ( )Tj EMC [(t)-16.7(h)-5.2(e t)-15.1(e)-23.9(x)-36(t)-20.1(:)]TJ /T1_2 1 Tf [( T)49.7(a)-4.9(t)-25.2(i)5.9(a)-0.8(n)4.8(a)]TJ /Span<>> BDC ( )Tj EMC [(V)53.1(.)]TJ /Span<>> BDC ( )Tj EMC [(S)15.3(h)4.8(ar)2.4(on)1.9(o)-0.6(v)10.8(a)-14(, )]TJ 0 Tw T* [(A)3.8(n)4.8(a)-3(s)-10.7(t)2.3(a)-3(s)-8.2(i)5.9(a)]TJ /Span<>> BDC ( )Tj EMC [(V)53.1(.)]TJ /Span<>> BDC ( )Tj EMC [(M)5.2(al)4.9(ek)]TJ /T1_3 1 Tf 0.023 Tw 0 -2.436 TD (\255\026\036\031\036\025\034\226 \017\223 \032\026\020\017\022\032\225 \(\ ORCID\))Tj /T1_1 1 Tf 0.119 Tw 0 -1.218 TD [(\221\026\030\024\027\024\r\026 )0.5(\230\026\021\034\016\027\026 )0.6(\200\026\035\036\030\034\036\r\027\026)]TJ /Span<>> BDC ( )Tj EMC 13.281 0 Td [(\227 )0.5(\022\026\027\007\017\007\026\021 )0.6(\b\017\n\017\004\036)]TJ 0 Tw (-)Tj 0.154 Tw -13.281 -1.218 Td [(\f\022\017\b )0.5(\027\026\031\022, )0.5(\027\026\031\004\027\t\005 )0.5(\f\024\021\030\031\007\027\017\022 )0.5(\035\026\002\024\030\026\021\024\030\017\017 )0.6(\f\031\002\022\035\036)]TJ 0 Tw (-)Tj -0.057 Tw T* (\021\024\004\027\t\b \021\036\b\027\024\035\024\020\017\005 \203\204\236\ \037 \024\027\022\024\035\024\020\017\017 \017\n. \203.\203. \215\036\021\ \030\024\r\026 )Tj 0 Tw T* (\204\017\027\007\030\026\r\026 \217\024\f\f\017\017; ORCID 0000-0002-53\ 72-1253)Tj 0.12 Tw T* (\025\026\007\026\027\006\036\r\026 \213\022\026\021\036\030\017\027\026 \ \233.)Tj /Span<>> BDC ( )Tj EMC (\227 \035\026\002\024\030\026\027\021-\017\f\f\035\036\007\024\r\026\021\ \036\035\034 )Tj 0.155 Tw T* (\035\026\002\024\030\026\021\024\030\017\017 \f\031\002\022\035\036\021\024\ \004\027\t\b \021\036\b\027\024\035\024\020\017\005 \203\204\236\037 \024\ \027\022\024)Tj 0 Tw (-)Tj 0.252 Tw T* (\035\024\020\017\017 \017\n. \203.\203. \215\036\021\030\024\r\026 \204\017\ \027\007\030\026\r\026 \217\024\f\f\017\017; ORCID )Tj 0 Tw T* (0009-0002-7238-5870)Tj -0.011 Tw T* (\025\026\006\031\002\026 \025\024\027\f\021\026\027\021\017\027 \213\r\020\ \036\027\034\036\r\017\004)Tj /Span<>> BDC ( )Tj EMC (\227 \035\026\002\024\030\026\027\021-\017\f\f\035\036\007\024)Tj 0 Tw (-)Tj 0.061 Tw T* (\r\026\021\036\035\034 \035\026\002\024\030\026\021\024\030\017\017 \f\031\ \002\022\035\036\021\024\004\027\t\b \021\036\b\027\024\035\024\020\017\005\ \203\204\236\037 )Tj 0.451 Tw T* (\024\027\022\024\035\024\020\017\017 \017\n. \203.\203. \215\036\021\030\ \024\r\026 \204\017\027\007\030\026\r\026 \217\024\f\f\017\017; )Tj 0 Tw T* (ORCID 0000-0002-7373-5206)Tj 0.347 Tw T* [(\025\024\r\026\035\036\027\022\024 )0.5(\236\030\017\027\026 )0.6(\204\017\b\026\005\035\024\r\027\026)]TJ /Span<>> BDC ( )Tj EMC 13.801 0 Td [(\227 )0.5(\022.\n.\027., )0.6(\027\026\031\004\027\t\005 )]TJ 0.832 Tw -13.801 -1.218 Td [(\f\024\021\030\031\007\027\017\022 )0.6(\035\026\002\024\030\026\021\024\030\017\017 )0.5(\f\031\002\022\035\036\021\024\004\027\t\b )0.6(\021\036\b\027\024\035\024)]TJ 0 Tw (-)Tj 0.223 Tw T* [(\020\017\005 )0.5(\203\204\236\037 \024\027\022\024\035\024\020\017\017 )0.5(\017\n. \203.\203. \215\036\021\030\024\r\026 )0.5(\204\017\027\007\030\026\r\026 )]TJ 0 Tw T* (\217\024\f\f\017\017; ORCID 0000-0002-0891-7687)Tj 0.02 Tw T* (\224\035\031\032\036\r \204\026\022\f\017\n \236\r\026\027\024\r\017\004\ )Tj /Span<>> BDC ( )Tj EMC (\227 \r\030\026\004-\024\027\022\024\035\024\020 \203\204\236\037 \024\027\ )Tj 0 Tw (-)Tj 0.092 Tw T* (\022\024\035\024\020\017\017 \017\n. \203.\203. \215\036\021\030\024\r\026\ \204\017\027\007\030\026\r\026 \217\024\f\f\017\017; ORCID )Tj 0 Tw T* (0000-0002-6346-1029)Tj 0.111 Tw T* (\224\036\n\017\020\035\026\024\r\026 \230\026\021\034\016\027\026 \222\030\ \034\036\r\027\026)Tj /Span<>> BDC ( )Tj EMC (\227 \007.\n.\027., \023\030\024\235\036\f\f\024\030, )Tj 0.293 Tw T* [(\026\r\036\007\031\033\013\026\016 \027\026\031\004\027\t\n )0.5(\024\021\007\036\035\024\n \017\027\027\024\r\026\006\017\024\027\027\t\b\ )0.5(\n\036)]TJ 0 Tw (-)Tj 0.279 Tw T* (\021\024\007\024\r \021\036\030\026\023\036\r\021\017\004\036\f\022\024\005\ \024\027\022\024\035\024\020\017\017 \017)Tj /Span<>> BDC ( )Tj EMC (\030\036\026\002\017\035\017\021\026\006\017\017 )Tj 0.595 Tw 23.244 57.237 Td (\203\204\236\037 \024\027\022\024\035\024\020\017\017 \017\n. \203.\203.\ \215\036\021\030\024\r\026 \204\017\027\007\030\026\r\026 )Tj 0 Tw T* (\217\024\f\f\017\017; ORCID 0000-0001-4305-6691)Tj 0.385 Tw T* (\207\031\030\006\036\r \212\n\017\021\030\017\005 \200\035\026\007\017\n\ \017\030\024\r\017\004)Tj /Span<>> BDC ( )Tj EMC (\227 \007.\n.\027., \023\030\036\017)Tj 0 Tw (-)Tj 0.617 Tw T* (\007\036\027\021 \212\017\026\020\027\024\f\021\017\004\036\f\022\024\005\ \204\036\007\017\006\017\027\f\022\024\005 \202\f\f\024\006\017\026\006\ \017\017 )Tj -0.036 Tw T* (\253\212\017\026\204\202\273, \020\035\026\r\027\t\005 \r\027\036\001\021\ \026\021\027\t\005 \f\023\036\006\017\026\035\017\f\021 \023\024)Tj /Span<>> BDC ( )Tj EMC (\025\212\214 \204\003 )Tj -0.03 Tw T* (\217\210, \020\035\026\r\027\t\005 \r\030\026\004 \206\202\211 \217\024\f\ \021\024\r\f\022\024\005 \024\002\035\026\f\021\017 \253\210\002\035\026\ \f\021\027\024\005 )Tj 0.452 Tw 0 -1.218 TD (\022\024\027\f\031\035\034\021\026\021\017\r\027\024-\007\017\026\020\027\ \024\f\021\017\004\036\f\022\017\005 \006\036\027\021\030\273, \026\r\036\ \007\031\033)Tj 0 Tw (-)Tj 0.24 Tw 0 -1.218 TD (\013\017\005 \022\026\235\036\007\030\024\005 \023\036\030\f\024\027\026\ \035\017\017\030\024\r\026\027\027\024\005 \017)Tj /Span<>> BDC ( )Tj EMC (\021\030\026\027\f\035\016\006\017)Tj 0 Tw (-)Tj 0.10