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\030\031\030\020\017\017 \037\224\211\200, \202\035\036\022\f\026\027\007\ \030 )Tj 0.551 Tw T* [(\225\036\030\020\036\036\r\017\004 )0.6(\027\026\004\026\035 )0.5(\030\026\002\024\021\031 )0.5(\027\026)]TJ /Span<>> BDC ( )Tj EMC 13.488 0 Td [(\027\024\r\024\005 )0.5(\022\035\017\027\017\004\036\f\022\024\005 )]TJ 0.088 Tw -13.488 -1.218 Td (\002\026\036)Tj /Span<>> BDC ( )Tj EMC (\227 \r)Tj /Span<>> BDC ( )Tj EMC (\020\024\030\024\007\f\022\024\005 \002\024\035\034\027\017\006\036 \f\022\ \024\030\024\005 \023\024\n\024\013\017 \22353. )Tj 0.314 Tw T* (\210\f\027\024\r\027\t\n \027\026\023\030\026\r\035\036\027\017\036\n \007\ \036\016\021\036\035\034\027\024\f\021\017 \202\035\036\022\f\026\027\007\ \030\026 )Tj -0.036 Tw T* (\225\036\030\020\036\036\r\017\004\026 \r)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\021 \023\036\030\017\024\007 \f\021\026\035\017 \r\024\023\030\ \024\f\t \024\030\020\026\027\017\026\006\017\017 )Tj 0.101 Tw T* (\b\017\030\031\030\020\017\004\036\f\022\024\005 \f\035\031\032\002\t \020\ .)Tj /Span<>> BDC ( )Tj EMC (\204\024\f\022\r\t, \r\027\036\007\030\036\027\017\036 \f\024\r\030\036)Tj 0 Tw (-)Tj 0.156 Tw T* (\n\036\027\027\t\b \n\036\021\024\007\024\r \007\017\026\020\027\024\f\021\ \017\022\017 \017)Tj /Span<>> BDC ( )Tj EMC (\035\036\004\036\027\017\016 \b\017\030\031\030\020\017\004\036)Tj 0 Tw (-)Tj 0.047 Tw T* (\f\022\024\005 \023\026\021\024\035\024\020\017\017 \017, \036\f\021\036\ \f\021\r\036\027\027\024, \r)Tj /Span<>> BDC ( )Tj EMC (\021.\004. \023\036\007\026\020\024\020\017\004\036\f\022\026\016 )Tj 0.338 Tw T* (\007\036\016\021\036\035\034\027\024\f\021\034, \027\026\023\030\026\r\035\ \036\027\027\026\016 \027\026)Tj /Span<>> BDC ( )Tj EMC (\023\024\007\020\024\021\024\r\022\031 \b\017\030\031\030)Tj 0 Tw (-)Tj 0.163 Tw T* (\020\024\r \020. \204\024\f\022\r\t. \200)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\021 \023\036\030\017\024\007 \f\021\026\035\026 \235\024\030\ \n\017\030\024\r\026\021\034\f\016 )Tj 0.168 Tw T* (\f\024\002\f\021\r\036\027\027\026\016 \027\026\031\004\027\026\016 \001\ \022\024\035\026. \224\n\036\027\027\024 \r)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\021 \023\036\030\017\024\007 )Tj 0.308 Tw T* (\202\035\036\022\f\026\027\007\030\024\n \225\036\030\020\036\036\r\017\004\ \036\n \002\t\035\017 \026\035\024\032\036\027\t \024\f\027\024\r\t )Tj 0.23 Tw T* (\035\036\004\036\002\027\024-\007\017\026\020\027\024\f\021\017\004\036\f\ \022\024\020\024 \022\024\n\023\035\036\022\f\026 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\r\024\f\023\026\035\017)Tj 0 Tw (-)Tj 0.215 Tw T* (\021\036\035\034\027\t\b \017)Tj /Span<>> BDC ( )Tj EMC [(\024\002\021\031\030\026\006\017\024\027\027\t\b \026\002\024\035\036\r\ \026\027\017\016\b )0.5(\002\017\035\017\026\030\027\024)]TJ 0 Tw (-)Tj 0.184 Tw T* (\020\024 \021\030\026\022\021\026, \023\024\035\031\004\017\r\001\036\020\ \024 \023\030\017\027\026\027\017\036 \031)Tj /Span<>> BDC ( )Tj EMC (\b\017\030\031\030\020\024\r \r\f\036\005 )Tj 0 Tw T* (\f\021\030\026\027\t.)Tj 0.08 Tw T* (\213\013\036 \r)Tj /Span<>> BDC ( )Tj EMC (1986 \020\024\007\031 \213\030\n\024\035\024\r \202.\225. \007\024\022\026\ \026\035 \006\036\035\036\f\024\024\002\030\026)Tj 0 Tw (-)Tj 0.248 Tw T* (\027\024\f\021\034 \024\030\020\026\027\017\026\006\017\017 \r)Tj /Span<>> BDC ( )Tj EMC (\f\024\f\021\026\r\036 \023\024\035\017\022\035\017\027\017\004\036\f\022\ \017\b \024\021)Tj 0 Tw (-)Tj 0.415 Tw T* (\007\036\035\036\027\017\005 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\022\030\031\023\027\t\b \f\021\026\006\017\024\027\026\030\026\b \026\n\ \002\031\035\026\021\024\030\027\t\b )Tj 0.167 Tw T* [(\b\017\030\031\030\020\017\004\036\f\022\017\b )0.6(\006\036\027\021\030\024\r, )0.5(\024\002\024\030\031\007\024\r\026\027\027\t\b )0.5(\024\023\036\030\026\006\017\024\027)]TJ 0 Tw (-)Tj 0.143 Tw T* (\027\t\n\017, \f\021\026\006\017\024\027\026\030\026\n\017 \024\007\027\024\ \020\024 \007\027\016, \f\024\024\021\r\036\021\f\021\r\031\033\013\017\n\ \017 )Tj 0.08 Tw T* (\001\021\026\021\026\n\017. \200\023\036\030\r\t\036 \r)Tj /Span<>> BDC ( )Tj EMC (\204\024\f\022\r\036 \021\026\022\024\005 \006\036\027\021\030 \002\t\035\ \024\021\022\030\t\021 )Tj 0.021 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC 1.227 0 Td [(\002\026\036 )0.5(\023\024\035\017\022\035\017\027\017\004\036\f\022\024\020\024 )0.5(\024\021\007\036\035\036\027\017\016 )0.6(\206\025\207 )0.5(\223 )0.5(53 )0.5($\f\036\005)]TJ 0 Tw (-)Tj -0.022 Tw -1.227 -1.218 Td (\004\026\f \206\025\207 \22313$. \215\030\024\024\002\030\026\024\n \220\ \021\024\020\024 \f\021\026\035\017 \027\t\027\036 \007\036\005\f\021\r\031\ )Tj 0 Tw (-)Tj 0.112 Tw T* (\033\013\017\036 \023\024)Tj /Span<>> BDC ( )Tj EMC (\r\f\036\005 \217\024\f\f\017\017 \017)Tj /Span<>> BDC ( )Tj EMC (\204\024\f\022\r\036 \f\021\026\006\017\024\027\026\030\t \022\030\026\021\ \022\024)Tj 0 Tw (-)Tj T* (\r\030\036\n\036\027\027\024\020\024 \023\030\036\002\t\r\026\027\017\016\ .)Tj 0.177 Tw T* (\200 1989 \020\024\007\031 \202\035\036\022\f\026\027\007\030 \225\036\030\ \020\036\036\r\017\004 \017\002\030\026\027 \026\r\036\007\031\033)Tj 0 Tw (-)Tj 0.172 Tw T* (\013\017\n 2-\005 \022\026\235\036\007\030\024\005 \b\017\030\031\030\020\ \017\017 \037\224\211\200 $\023\036\030\036\017\n\036\027\024\r\026\027\ \026 )Tj -0.004 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (2005 \020\024\007\031 \r)Tj /Span<>> BDC ( )Tj EMC (\022\026\235\036\007\030\031 \027\036\024\021\035\024\032\027\024\005 \017\ )Tj /Span<>> BDC ( )Tj EMC (\024\002\013\036\005 \b\017\030\031\030\020\017\017 )Tj 0.037 Tw T* (\217\204\202\215\210$, \022\024\021\024\030\024\005 \r)Tj /Span<>> BDC ( )Tj EMC (\007\026\035\034\027\036\005\001\036\n \024\027 \026\r\036\007\024\r\026\ \035 29 \035\036\021. )Tj 0.005 Tw T* (\200)Tj /Span<>> BDC ( )Tj EMC (\030\031\022\024\r\024\007\017\n\024\005 \017\n \022\035\017\027\017\022\ \026\b \022\026\235\036\007\030\t \026\022\021\017\r\027\024 \030\026\r\ \017)Tj 0 Tw (-)Tj 0.11 Tw T* (\r\026\035\026\f\034 \027\036 \021\024\035\034\022\024 \027\036\024\021\035\ \024\032\027\026\016 \b\017\030\031\030\020\017\016, \027\024 \017)Tj /Span<>> BDC ( )Tj EMC (\023\035\026\027\024)Tj 0 Tw (-)Tj 0.172 Tw T* (\r\026\016 \b\017\030\031\030\020\017\016 \024\030\020\026\027\024\r \032\ \036\035\031\007\024\004\027\024-\022\017\001\036\004\027\024\020\024 \021\ \030\026\022\021\026 )Tj 0.26 Tw 23.244 64.543 Td (\017)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\007\027\024\005 \022\035\036\021\022\017, \026)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\032\036 \220\027\007\024\022\030\017\027\027\026\016 \b\017\ \030\031\030\020\017\016. )Tj 0.218 Tw T* [(\207\024\035\034\001\024\036 \r\027\017\n\026\027\017\036 \031\007\036\035\ \016\035\024\f\034 )0.5(\023\030\024\002\035\036\n\036 \031\035\031\004\001\036\027\017\016 )]TJ 0.032 Tw T* [(\030\036\031\035\034\021\026\021\024\r \035\036\004\036\027\017\016 )0.5(\002\024\035\034\027\t\b, \021\030\036\002\031\033\013\017\b \023\024\r\021\ \024\030\027\t\b )]TJ 0.376 Tw T* (\030\036\022\024\027\f\021\030\031\022\021\017\r\027\t\b \024\023\036\030\ \026\006\017\005 \027\026)Tj /Span<>> BDC ( )Tj EMC (\024\030\020\026\027\026\b \032\036\035\031\007\024\004)Tj 0 Tw (-)Tj 0.103 Tw T* (\027\024-\022\017\001\036\004\027\024\020\024 \021\030\026\022\021\026, \ \024\f\024\002\024 \021\016\032\036\035\t\b \020\030\031\023\023 \002\024\ \035\034\027\t\b )Tj 0.473 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\022\017\001\036\004\027\t\n\017 \f\r\017\013\026\n\017, \023\026\021\024\ \035\024\020\017\036\005 \220\027\007\024\022\030\017\027\027\t\b )Tj 0 Tw 0 -1.218 TD (\024\030\020\026\027\024\r.)Tj 0.379 Tw 0 -1.218 TD (\200 1992 \020\024\007\031 \030\031\022\024\r\024\007\f\021\r\024 \020.)Tj /Span<>> BDC ( )Tj EMC (\204\024\f\022\r\t \023\030\036\007\035\024\032\017\035\024 )Tj 0.391 Tw T* (\202.\225.)Tj /Span<>> BDC ( )Tj EMC [(\213\030\n\024\035\024\r\031 \r\024\020\035\026\r\017\021\034 )0.5(\204\024\f\022\024\r\f\022\017\005 \027\026\031\004\027\024-\017\f)]TJ 0 Tw (-)Tj 0.458 Tw T* (\f\035\036\007\024\r\026\021\036\035\034\f\022\017\005 \017\027\f\021\017\ \021\031\021 \f\022\024\030\024\005 \023\024\n\024\013\017 \017\n\036\027\ \017 )Tj 0 Tw T* (\203.\200.)Tj /Span<>> BDC ( )Tj EMC (\225\022\035\017\235\024\f\024\r\f\022\024\020\024.)Tj 0.065 Tw T* (\215\030\017\007\016 \r)Tj /Span<>> BDC ( )Tj EMC (\017\027\f\021\017\021\031\021, \202\035\036\022\f\026\027\007\030 \225\036\ \030\020\036\036\r\017\004 \f\030\026\031 \032\036 \026)Tj 0 Tw (-)Tj 0.054 Tw 0 -1.218 TD [(\016\r\017\035 \023\036\030\036\007 \r\f\036\n \022\024\035\035\036\022\021\ \017\r\024\n, )0.5(\004\021\024 \024\f\027\024\r\027\024\005 )0.5(\026\007\026\004\036\005 )]TJ 0.045 Tw 0 -1.218 TD [(\036\020\024, )0.5(\022\026\022 )0.5(\007\017\030\036\022\021\024\030\026 )0.5(\002\031\007\036\021 )0.5(\r\024\f\f\021\026\027\024\r\035\036\027\017\036 )0.6(\021\036\030\030\017\021\024\030\017)]TJ 0 Tw (-)Tj -0.02 Tw 0 -1.218 TD (\026\035\034\027\024\005 \006\036\035\024\f\021\027\024\f\021\017 \017\027\ \f\021\017\021\031\021\026, \r\024\030\026\013\036\027\017\036 \017\027\ \f\021\017\021\031\021\031 )Tj 0.113 Tw T* (\020\035\026\r\027\024\020\024 \022\024\030\023\031\f\026, \030\036\022\024\ \027\f\021\030\031\022\006\017\016 \r\f\036\b \007\026\027\017\005 \017\ )Tj /Span<>> BDC ( )Tj EMC (\r\t)Tj 0 Tw (-)Tj -0.018 Tw T* (\r\036\007\036\027\017\036 \017\027\f\021\017\021\031\021\026 \027\026)Tj /Span<>> BDC ( )Tj EMC (\f\024\r\030\036\n\036\027\027\031\033 \n\026\021\036\030\017\026\035\034\ \027\024-\021\036\b)Tj 0 Tw (-)Tj T* (\027\017\004\036\f\022\031\033 \002\026\031.)Tj 0.301 Tw T* (\003\026 \022\024\030\024\021\022\017\005 \023\030\024\n\036\032\031\021\ \024\022 \r\030\036\n\036\027\017 \024\021\022\030\t\021\t \f\024\r\030\036\ )Tj 0 Tw (-)Tj 0.207 Tw T* (\n\036\027\027\024\036 \037\225\210, \024\032\024\020\024\r\t\005 \006\036\ \027\021\030, \030\036\022\024\027\f\021\030\031\017\030\024\r\026\027\027\ \t\005 )Tj 0.125 Tw T* (\021\024\022\f\017\022\024\035\024\020\017\004\036\f\022\017\005 \022\024\ \030\023\031\f \f)Tj /Span<>> BDC ( )Tj EMC (\024\021\007\036\035\036\027\017\036\n \007\035\016 \023\f\017\b\024)Tj 0 Tw (-)Tj 0.274 Tw T* (\f\024\n\026\021\017\004\036\f\022\017\b \030\026\f\f\021\030\024\005\f\021\ \r, \023\030\026\004\036\004\027\026\016 \017)Tj /Span<>> BDC ( )Tj EMC (\007\036\017\027\235\036\022)Tj 0 Tw (-)Tj 0.093 Tw T* (\006\017\024\027\027\t\005 \002\035\024\022. \200)Tj /Span<>> BDC ( )Tj EMC (2000 \020\024\007\031 \024\021\022\030\t\021 \206\024\030\024\007\f\022\024\ \005 \006\036\027\021\030 )Tj 0.147 Tw T* [(\021\030\026\027\f\023\035\026\027\021\026\006\017\017 )0.6(\023\036\004\036\027\017 )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC 11.22 0 Td [(\023\030\024\r\036\007\036\027\026 )0.5(\023\036\030\r\026\016 )0.6(\031\f\023\036\001)]TJ 0 Tw (-)Tj 0.026 Tw -11.22 -1.218 Td (\027\026\016 \023\036\030\036\f\026\007\022\026 \021\030\031\023\027\024\ \005 \023\036\004\036\027\017 \r)Tj /Span<>> BDC ( )Tj EMC (\217\024\f\f\017\017. \200)Tj /Span<>> BDC ( )Tj EMC (2001 \020\024\007\031 )Tj 0.393 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\027\024\r\024\n \022\024\030\023\031\f\036 \024\021\022\030\t\021\024 \024\ \021\007\036\035\036\027\017\036 \027\036\024\021\035\024\032\027\024\005\ )Tj 0.049 Tw T* (\022\026\030\007\017\024\b\017\030\031\030\020\017\017. \200)Tj /Span<>> BDC ( )Tj EMC (2004 \020\024\007\031 \026\022\024\027\004\036\027\026 \030\036\022\024\ \027\f\021\030\031\022)Tj 0 Tw (-)Tj 0.213 Tw T* [(\006\017\016 )0.5(\024\027\t \207 )0.6(\f)]TJ /Span<>> BDC ( )Tj EMC 6.326 0 Td [(\023\024\035\027\t\n )0.5(\036\036 )0.5(\023\036\030\036\024\f\027\026\013\036\027\017\036\n )0.6($\023\030\017\036\n)]TJ 0 Tw (-)Tj 0.329 Tw -6.326 -1.218 Td (\027\024-\007\017\026\020\027\024\f\021\017\004\036\f\022\024\036 \024\021\ \007\036\035\036\027\017\036, 4 \030\036\026\027\017\n\026\006\017\024\027\ \027\t\b )Tj 0.352 Tw T* (\024\021\007\036\035\036\027\017\016, \220\022\f\021\030\036\027\027\t\005\ \024\023\036\030\026\006\017\024\027\027\t\005 \002\035\024\022 \017)Tj /Span<>> BDC ( )Tj EMC (\007\030. )Tj 0.309 Tw T* [(\024\021\007\036\035\036\027\017\016$. )0.5(\217\036\022\024\027\f\021\030\031\017\030\024\r\026\027 \f)]TJ /Span<>> BDC ( )Tj EMC (\023\024\035\027\t\n \023\036\030\036\024\f\027\026)Tj 0 Tw (-)Tj 0.128 Tw T* (\013\036\027\017\036\n \022\024\030\023\031\f \223 11, \f)Tj /Span<>> BDC ( )Tj EMC (\024\021\022\030\t\021\017\036\n \r)Tj /Span<>> BDC ( )Tj EMC (\027\036\n \024\021\007\036\035\036\027\017\016 )Tj 0 Tw T* (\021\030\026\027\f\235\031\017\024\035\024\020\017\017.)Tj 0.002 Tc 0.828 Tw T* [(\203\036\017\n\024\r\036\030\027\t\n\017 \031\f\017\035\017\016\n\017 \202\ \035\036\022\f\026\027\007\030 \225\036\030\020\036\036\r\017\004)2( )]TJ 0.483 Tw T* (\007\024\002\017\035\f\016 \r\024\030\026\013\036\027\017\016 \r)Tj /Span<>> BDC ( )Tj EMC [(\225\022\035\017\235 \020\035\026\r\027\024\020\024 \022\024\030\023\031\ \f\026)2( )]TJ 0.457 Tw T* (\221\036\030\036\n\036\021\034\036\r\f\022\024\020\024 \026\030\b\017\021\ \036\022\021\031\030\027\024\020\024 \026\027\f\026\n\002\035\016, \f\021\ \026\r)Tj 0 Tc 0 Tw (-)Tj 0.002 Tc 0.445 Tw T* [(\001\036\020\024 \007\035\016 \n\024\f\022\r\017\004\036\005 \f\017\n\r\024\ \035\024\n \224\027\f\021\017\021\031\021\026 \017\n\036\027\017)2.1( )]TJ 0.153 Tw T* (\203.\200. \225\022\035\017\235\024\f\024\r\f\022\024\020\024. \200)Tj /Span<>> BDC ( )Tj EMC [(2001 \020\024\007\031 \002\t\035\026 \027\026\004\026\021\026 \036\020\024\ )2( )]TJ 0.627 Tw T* (\030\036\022\024\027\f\021\030\031\022\006\017\016 \f)Tj /Span<>> BDC ( )Tj EMC (\007\026\035\034\027\036\005\001\017\n \026\r\036\030\001\036\027\017\036\ \n \030\036)Tj 0 Tc 0 Tw (-)Tj 0.002 Tc 0.624 Tw T* [(\022\024\027\f\021\030\031\022\006\017\017 \r\f\036\020\024 \026\027\f\026\ \n\002\035\016 \253\225\021\030\026\027\027\024\023\030\017\017\n\027\t\005\ )2( )]TJ 0.148 Tw T* (\007\024\n \020\030\026\235\026 \221\036\030\036\n\036\021\036\r\026\273\ \r)Tj /Span<>> BDC ( )Tj EMC (2006 \020\024\007\031. \230\021\024 \027\036\024\006\036\027\017)Tj 0 Tc 0 Tw (-)Tj 0.002 Tc 0.26 Tw T* (\n\t\005 \r\022\035\026\007 \202\035\036\022\f\026\027\007\030\026 \225\036\ \030\020\036\036\r\017\004\026 \r)Tj /Span<>> BDC ( )Tj EMC [(\r\024\030\024\032\007\036\027\017\036)2( )]TJ 0.333 Tw T* (\f\017\n\r\024\035\026 \203\224\224 \225\215 \017\n. \203.\200. \225\022\ \035\017\235\024\f\024\r\f\022\024\020\024, \022\031\035\034)Tj 0 Tc 0 Tw (-)Tj 0.002 Tc 0.277 Tw T* [(\021\031\030\027\024\020\024 )0.5(\027\026\f\035\036\007\017\016 )0.5(\204\024\f\022\r\t. )0.5(\200\f\036\020\024 )0.5(\023\030\017)]TJ /Span<>> BDC ( )Tj EMC 16.955 0 Td [(\030\031\022\024\r\024\007\f\021\r\036)2( )]TJ 0.039 Tw -16.955 -1.218 Td (\202\035\036\022\f\026\027\007\030\026 \225\036\030\020\036\036\r\017\004\ \026 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Devel)30.1(opment and v)-15(al)-30.9(id)41.9(a)15.1(t)-32(ion of )]TJ 0.273 Tw -1.796 -1.25 Td [(MRI-based )0.6(deep )0.5(lear)-15(ning )0.5(models )0.6(for )0.6(p)25(r)-24(edic)-16(t)-32(ion )0.6(of )0.5(micr)-31.9(osa)15(tell)-31(i)-23.9(te )]TJ 0.281 Tw 0 -1.25 TD [(inst)15(abil)-30.9(i)-24(t)-10(y )0.6(in )0.5(r)-24(ec)-15.9(t)15(al )0.6(cancer. )]TJ /T1_2 1 Tf 12.27 0 Td [(Cancer )0.6(Med.)]TJ /T1_1 1 Tf [( )0.6(2021 )0.6(Jun;10$12$:4164\226)]TJ 0.023 Tw -12.27 -1.25 Td [(4173. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1002/cam4.3957)Tj 0 0 0 1 k /GS1 gs 0.25 Tw T* (21.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Cui)Tj /Span<>> BDC ( )Tj EMC [(Y, L)-32(iu)]TJ /Span<>> BDC ( )Tj EMC [(H, R)13(en)]TJ /Span<>> BDC ( )Tj EMC [(J, e)-11.9(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Devel)30.1(opment and v)-15(al)-31(id)42(a)15(t)-32(ion of a )]TJ 0.142 Tw -1.796 -1.25 Td [(MRI-based r)-32.9(adiomics signa)15(tur)-23.9(e for p)25(r)-24(edic)-15.9(t)-32(ion of KRA)35(S mut)15(a)15.1(t)-32(ion in )]TJ 0.049 Tw T* [(r)-24(ec)-16(t)15.1(al cancer. )]TJ /T1_2 1 Tf [(Eur R)20(adiol.)]TJ /T1_1 1 Tf [( 2020 Ap)25(r;30$4$:1948\2261958. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1007/)Tj T* (s00330-019-06572-3)Tj 0 0 0 1 k /GS1 gs 0.003 Tw T* (22.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(L)-32(iu)]TJ /Span<>> BDC ( )Tj EMC [(H, Y)-28.9(in)]TJ /Span<>> BDC ( )Tj EMC [(H, L)-32(i)]TJ /Span<>> BDC ( )Tj EMC [(J, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. A Deep L)35(ear)-15(ning M)-24(odel Based on MRI and )]TJ 0.03 Tw -1.796 -1.25 Td [(Cl)-31(inical )0.6(F)20(a)-17(c)-16(t)17(or)-10(s )0.6(F)20(a)-17(c)-24(il)-31(i)-24(t)15.1(a)15(tes )0.5(N)-14(oninv)-14.9(asi)-16(ve )0.5(Ev)-14.9(al)35(ua)15(t)-32(ion )0.5(of )0.6(KRA)35(S )0.5(Mut)15.1(a)15(t)-32(ion )]TJ -0.003 Tw T* [(in R)13(ec)-16(t)15(al Cancer. )]TJ /T1_2 1 Tf [(J Magn R)21(eson Imaging.)]TJ /T1_1 1 Tf ( 2022 Dec;56$6$:1659\2261668. )Tj 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td [(10.1002/jmr)-36.9(i.28237)]TJ 0 0 0 1 k /GS1 gs 0.047 Tw -1.847 -1.25 Td (23.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(S)-16(hi)]TJ /Span<>> BDC ( )Tj EMC (R, Chen)Tj /Span<>> BDC ( )Tj EMC [(W, Y)50(ang)]TJ /Span<>> BDC ( )Tj EMC [(B, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. P)35(r)-24(edic)-16(t)-32(ion of KRA)35(S, NRA)35(S and BRAF )]TJ -0.033 Tw -1.796 -1.25 Td [(st)15(a)15(tus in col)30(or)-24(ec)-16(t)15.1(al cancer p)32(a)15(t)-31.9(ients wi)-24(t)-13(h l)-31(i)-16(ver me)-12(t)15.1(ast)15(asis using a deep )]TJ 0.044 Tw T* [(ar)-22(t)-32(if)-27.9(ic)-24(ial neur)-33(al ne)-12(t)-32(w)-14(or)-24(k based on r)-32.9(adiomics and semant)-31.9(ic fea)15(tur)-24(es. )]TJ /T1_2 1 Tf 0.023 Tw T* [(Am J Cancer R)21(es.)]TJ /T1_1 1 Tf ( 2020 Dec 1;10$12$:4513\2264526)Tj 0.129 Tw T* (24.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(T)40(aieb)]TJ /Span<>> BDC ( )Tj EMC (J, Andr\351)Tj /Span<>> BDC ( )Tj EMC [(T, A)10(ucl)-31(in)]TJ /Span<>> BDC ( )Tj EMC [(E. R)12.9(ef)-27.9(ining ad)17(juv)-15(ant t)-13(her)-32.9(apy for non-)]TJ 0.261 Tw -1.796 -1.25 Td [(me)-12(t)15(ast)15.1(a)14.9(t)-31.9(ic col)30.1(on cancer, new st)15(and)42(ar)-23.9(ds and per)-10(spec)-16(t)-31.9(i)-16(ves. )]TJ /T1_2 1 Tf 0 Tw (Cancer )Tj 0.023 Tw T* [(T)56(reat R)21(ev.)]TJ /T1_1 1 Tf [( 2019 Ma)15(y;75:1\22611. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw [(10.1016/j.c)-16(tr)-31.9(v.2019.02.002)]TJ 0 0 0 1 k /GS1 gs -0.011 Tw T* (25.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Kleppe)Tj /Span<>> BDC ( )Tj EMC [(A, S)-16(kr)-23.9(ede)]TJ /Span<>> BDC ( )Tj EMC [(OJ, De R)-9.9(aed)16.9(t)]TJ /Span<>> BDC ( )Tj EMC [(S, e)-11.9(t)]TJ /Span<>> BDC ( )Tj EMC [(al. A cl)-30.9(inical dec)-24(ision suppor)-21.9(t )]TJ 0.075 Tw -1.796 -1.25 Td [(sy)-13(stem opt)-32(imising ad)17(juv)-15(ant chemo)17(t)-12.9(her)-33(apy for col)30.1(or)-24(ec)-16(t)15(al cancer)-10(s b)12(y )]TJ 0.006 Tw T* [(integr)-33(a)15.1(t)-32(ing deep lear)-15(ning and p)32(a)15(t)-12.9(hol)30(o)-16(gical st)15(a)-17(ging mar)-24(k)10(er)-10(s: a devel)]TJ 0 Tw (-)Tj 0.147 Tw T* [(opment and )0.5(v)-15(al)-31(id)42(a)15(t)-32(ion )0.5(stud)17(y. )]TJ /T1_2 1 Tf [(Lancet )0.5(Oncol.)]TJ /T1_1 1 Tf ( 2022 Sep;23$9$:1221\226)Tj 0.023 Tw T* [(1232. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1016/S1470-2045$22$00391-6)Tj 0 0 0 1 k /GS1 gs 0.332 Tw T* (26.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(S)-16(kr)-24(ede)]TJ /Span<>> BDC ( )Tj EMC [(OJ, De R)-10(aed)17(t)]TJ /Span<>> BDC ( )Tj EMC (S, Kleppe)Tj /Span<>> BDC ( )Tj EMC [(A, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Deep lear)-14.9(ning for )]TJ 0.23 Tw -1.796 -1.25 Td [(p)25(r)-24(edic)-16(t)-31.9(ion of col)30(or)-23.9(ec)-16(t)15(al cancer outcome: a discover)-23.9(y and v)-15(al)-30.9(id)42(a)]TJ 0 Tw (-)Tj 0.079 Tw T* [(t)-32(ion stud)17(y. )]TJ /T1_2 1 Tf 0 Tw (Lancet.)Tj /T1_1 1 Tf 0.079 Tw [( 2020 F)10(eb 1;395$10221$:350\226360. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1016/)Tj T* (S0140-6736$19$32998-8)Tj 0 0 0 1 k /GS1 gs 0.039 Tw T* (27.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Suw)-12(anvecho)]TJ /Span<>> BDC ( )Tj EMC [(S, Suw)-12(anr)-22(us)26(me)]TJ /Span<>> BDC ( )Tj EMC [(H, Jir)-33(akul)-15.9(apor)-15(n)]TJ /Span<>> BDC ( )Tj EMC [(T, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Com)10(p)31.9(ar)-36.9(ison )]TJ 0.084 Tw -1.796 -1.25 Td [(of an oncol)30(o)-16(g)16(y cl)-31(inical dec)-24(ision-suppor)-21.9(t sy)-13(stem\254s r)-23.9(ecommend)42(a)15(t)-32(ions )]TJ 0.102 Tw T* [(wi)-24(t)-13(h a)-17(c)-15.9(tual tr)-24(ea)15(tment dec)-24(isions. )]TJ /T1_2 1 Tf [(J Am Med Infor)-14(m Assoc.)]TJ /T1_1 1 Tf ( 2021 Mar )Tj 0.023 Tw T* [(18;28$4$:832\226838. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw [(10.1093/jamia/o)-16(caa334)]TJ 0 0 0 1 k /GS1 gs 0.284 Tw T* (28.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(L)35(uo)]TJ /Span<>> BDC ( )Tj EMC (XJ, Zhao)Tj /Span<>> BDC ( )Tj EMC [(Q, L)-32(iu)]TJ /Span<>> BDC ( )Tj EMC [(J, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. N)-14(ovel Gene)-12(t)-32(ic and Epigene)-12(t)-32(ic )]TJ 0.005 Tc 0.35 Tw -1.796 -1.25 Td [(Biomar)-24.2(k)9.7(er)-10.3(s of P)34.8(r)-32.3(o)-16.2(gnost)-32.3(ic and P)34.7(r)-24.2(edic)-16.2(t)-32.3(i)-16.2(ve S)-16.3(ignif)-28.2(icance in S)14.7(t)14.7(a)-17.2(ge)5( )]TJ T* [(II/III Col)29.6(or)-24.4(ec)-16.4(t)14.5(al Cancer. )]TJ /T1_2 1 Tf (Mol Ther.)Tj /T1_1 1 Tf 0.006 Tc 0.349 Tw [( 2)0.6(0)0.5(2)0.6(1)0.5( F)10.5(e)0.6(b)0.5( 3)0.6(;)0.5(2)0.6(9)0.5($)0.6(2)0.5($)0.6(:)0.6(5)0.5(8)0.6(7)0.5(\226)0.6(5)0.5(9)0.6(6)0.5(.)6( )]TJ 0 Tc 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td [(10.1016/j.ym)16(t)-12.9(he.2020.12.017)]TJ 0 0 0 1 k /GS1 gs 0.107 Tw -1.847 -1.25 Td (29.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(L)-32(iu)]TJ /Span<>> BDC ( )Tj EMC [(Z, L)-32(iu)]TJ /Span<>> BDC ( )Tj EMC [(L, W)22(eng)]TJ /Span<>> BDC ( )Tj EMC [(S, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Ma)-17(chine lear)-15(ning-based integr)-33(a)15(t)-32(ion )]TJ 0.188 Tw -1.796 -1.25 Td [(devel)30(ops an immune-der)-37(i)-16(ved lncRN)13(A signa)15(tur)-24(e for im)10(p)25(r)-32(ov)-16(ing out)]TJ 0 Tw (-)Tj 0.187 Tw T* [(comes in col)30(or)-24(ec)-16(t)15(al cancer. )]TJ /T1_2 1 Tf [(N)18(at Commun.)]TJ /T1_1 1 Tf [( 2022 F)10(eb 10;13$1$:816. )]TJ 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1038/s41467-022-28421-6)Tj 0 0 0 1 k /GS1 gs 0.249 Tw -1.847 -1.25 Td (30.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(A)-14(br)-33(aham)]TJ /Span<>> BDC ( )Tj EMC [(JP, Ma)-17(gee)]TJ /Span<>> BDC ( )Tj EMC [(D, Cr)-24(emol)-31(ini)]TJ /Span<>> BDC ( )Tj EMC [(C, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Cl)-31(inical V)25(al)-31(id)42(a)15(t)-32(ion )]TJ 0.295 Tw -1.796 -1.25 Td [(of a Ma)-17(chine-lear)-14.9(ning-der)-37(i)-16(ved S)-16(igna)15(tur)-24(e P)35(r)-24(edic)-16(t)-32(i)-15.9(ve of Outcomes )]TJ 0.014 Tc 0.504 Tw T* [(fr)-31.8(om F)-18.8(ir)-9.7(st-l)-30.7(ine Ox)-10.7(al)-30.7(ipl)-15.7(a)15.2(t)-31.7(in-based Chemo)17.2(t)-12.7(her)-32.8(apy in A)15.3(d)-16.8(v)-14.7(anced)14( )]TJ 0 Tc 0.19 Tw T* [(Col)30(or)-23.9(ec)-16(t)15(al Cancer. )]TJ /T1_2 1 Tf 7.823 0 Td [(Clin Cancer )0.5(R)21(es)]TJ /T1_1 1 Tf [(. )0.5(2021 F)10(eb 15;27$4$:1174\2261183. )]TJ 0 Tw -7.823 -1.25 Td [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1158/1078-0432.CCR-20-3286)Tj 0 0 0 1 k /GS1 gs 0.34 Tw -1.847 -1.25 Td (31.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Giannini)Tj /Span<>> BDC ( )Tj EMC [(V, R)11(osa)15(t)-32(i)]TJ /Span<>> BDC ( )Tj EMC (S, Defeudis)Tj /Span<>> BDC ( )Tj EMC [(A, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. R)-10(adiomics p)25(r)-24(edic)-16(ts )]TJ 0.01 Tw -1.796 -1.25 Td [(r)-24(esponse of indi)-15.9(v)-16(idual HER2-am)10.1(pl)-31(if)-28(ied col)30(or)-24(ec)-16(t)15.1(al cancer )0.5(l)-31(i)-16(ver me)-12(t)15(as)]TJ 0 Tw (-)Tj 0.095 Tw T* [(t)15(ases in p)32(a)15(t)-32(ients tr)-24(ea)15(ted wi)-24(t)-12.9(h HER2-t)15.1(ar)-32(ge)-12(ted t)-13(her)-33(apy. )]TJ /T1_2 1 Tf (Int J Cancer.)Tj /T1_1 1 Tf 0 Tw ( )Tj 0.023 Tw T* [(2020 Dec 1;147$11$:3215\2263223. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1002/ijc.33271)Tj 0 0 0 1 k /GS1 gs -0.034 Tw T* (32.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Manfr)-23.9(edi)]TJ /Span<>> BDC ( )Tj EMC 3.747 0 Td [(S, )0.5(Bouv)-15.9(ier)]TJ /Span<>> BDC ( )Tj EMC 4.13 0 Td [(AM, )0.6(L)35(ep)32(a)-17(ge)]TJ /Span<>> BDC ( )Tj EMC 4.596 0 Td [(C, )0.5(e)-12(t)]TJ /Span<>> BDC ( )Tj EMC 1.88 0 Td [(al. )0.6(Inc)-24(idence )0.6(and )0.5(p)32(a)15(t)-30(ter)-15(ns )0.6(of )]TJ -0.017 Tw -16.149 -1.25 Td [(r)-24(ecur)-23.9(r)-24(ence af)-28(ter r)-24(esec)-16(t)-32(ion for cur)-24(e of col)30(onic cancer in a well def)-28(ined )]TJ 0 Tw T* [(popul)-16(a)15(t)-32(ion. )]TJ /T1_2 1 Tf 0.023 Tw 4.979 0 Td (Br J Surg)Tj /T1_1 1 Tf [(. 2006;93:1115\2261122. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1002/bjs.5349)Tj 0 0 0 1 k /GS1 gs 0.034 Tw -4.979 -1.25 Td (33.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Badic)Tj /Span<>> BDC ( )Tj EMC (B, Da-Ano)Tj /Span<>> BDC ( )Tj EMC [(R, P)10.1(oir)-32(o)17(t)]TJ /Span<>> BDC ( )Tj EMC [(K, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. P)35(r)-24(edic)-15.9(t)-32(ion of r)-23.9(ecur)-24(r)-24(ence af)-28(ter )]TJ -0.029 Tw -1.796 -1.25 Td [(sur)-32(ger)-23.9(y in col)30(or)-23.9(ec)-16(t)15(al cancer p)32(a)15(t)-32(ients using r)-33(adiomics fr)-31.9(om dia)-17(gnost)-32(ic )]TJ 0.139 Tw T* [(contr)-33(ast-enhanced com)10(puted t)17(omo)-16(gr)-32.9(aphy: a t)-32(w)-13.9(o-center stud)17(y. )]TJ /T1_2 1 Tf 0 Tw (Eur )Tj T* [(R)20(adiol. )]TJ /T1_1 1 Tf 0.012 Tw 2.996 0 Td [(2022 Jan;32$1$:405\226414. d)-15.9(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1007/s00330-021-08104-4)Tj 0 0 0 1 k /GS1 gs 0.128 Tw -2.996 -1.25 Td (34.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Xu)Tj /Span<>> BDC ( )Tj EMC (Y, Ju)Tj /Span<>> BDC ( )Tj EMC [(L, T)45(ong)]TJ /Span<>> BDC ( )Tj EMC [(J, e)-11.9(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Ma)-17(chine lear)-14.9(ning al)16(gor)-36.9(i)-24(t)-13(hms for p)25(r)-23.9(e)]TJ 0 Tw (-)Tj 0.235 Tw 27.259 71.25 Td [(dic)-16(t)-32(ing t)-13(he r)-24(ecur)-23.9(r)-24(ence of st)15(a)-17(ge IV col)30(or)-24(ec)-16(t)15(al cancer af)-28(ter tumor )]TJ 0 Tw T* [(r)-24(esec)-15.9(t)-32(ion. )]TJ /T1_2 1 Tf -0.014 Tw 4.312 0 Td [(Sci R)21(ep)]TJ /T1_1 1 Tf [(. 2020;10:2519. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1038/s41598-020-59115-y)Tj 0 0 0 1 k /GS1 gs 0.05 Tw -4.312 -1.25 Td (35.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Han)Tj /Span<>> BDC ( )Tj EMC [(T, )0.5(Zhu)]TJ /Span<>> BDC ( )Tj EMC 4.568 0 Td [(J, )0.5(Chen)]TJ /Span<>> BDC ( )Tj EMC 3.173 0 Td [(X, e)-11.9(t)]TJ /Span<>> BDC ( )Tj EMC [(al. )0.5(Appl)-31(ica)15(t)-32(ion )0.5(of ar)-21.9(t)-32(if)-28(ic)-24(ial )0.5(intell)-31(igence )]TJ 0.147 Tw -9.537 -1.25 Td [(in a r)-24(eal-w)-14(or)-30(ld r)-23.9(esear)-32(ch for p)25(r)-24(edic)-16(t)-32(ing t)-13(he r)-37(isk of l)-31(i)-15.9(ver me)-12(t)15(ast)15(asis )]TJ 0.319 Tw T* [(in )0.5(T1 col)30(or)-24(ec)-16(t)15(al )0.5(cancer. )]TJ /T1_2 1 Tf 10.883 0 Td [(Cancer )0.5(Cell Int.)]TJ /T1_1 1 Tf [( 2022 Jan )0.5(15;22$1$:28. )]TJ 0 Tw -10.883 -1.25 Td [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1186/s12935-021-02424-7)Tj 0 0 0 1 k /GS1 gs 0.11 Tw -1.847 -1.25 Td (36.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Elf)-28(ik)-31.9(y)]TJ /Span<>> BDC ( )Tj EMC [(AA, P)40(any)]TJ /Span<>> BDC ( )Tj EMC [(MJ, P)40(ar)-37(ikh)]TJ /Span<>> BDC ( )Tj EMC [(RB, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Devel)30(opment and appl)-31(ica)]TJ 0 Tw (-)Tj 0.078 Tw -1.796 -1.25 Td [(t)-32(ion of a ma)-17(chine lear)-14.9(ning app)25(r)-32(oa)-17(ch t)17(o assess shor)-22(t-ter)-15.9(m mor)-21.9(t)15(al)-31(i)-24(t)-10(y )]TJ 0.066 Tw T* [(r)-37(isk among p)32(a)15(t)-32(ients wi)-24(t)-13(h cancer st)15(ar)-22(t)-32(ing chemo)17(t)-13(her)-32.9(apy. )]TJ /T1_2 1 Tf [(J)30(AMA N)18(etw )]TJ 0 Tw T* (Open)Tj /T1_1 1 Tf 0.023 Tw [(. 2018;1:e180926. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw [(10.1001/jamane)-11.9(t)-32(w)-14(or)-24(kopen.2018.0926)]TJ 0 0 0 1 k /GS1 gs 0.314 Tw T* (37.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Y)50(ang)]TJ /Span<>> BDC ( )Tj EMC 2.459 0 Td [(M, )0.5(Y)50(ang)]TJ /Span<>> BDC ( )Tj EMC 3.858 0 Td [(H, )0.5(Ji)]TJ /Span<>> BDC ( )Tj EMC 2.619 0 Td [(L, )0.5(e)-11.9(t)]TJ /Span<>> BDC ( )Tj EMC 2.553 0 Td [(al. )0.6(A )0.5(mul)56(t)-32(i-omics )0.6(ma)-17(chine )0.6(lear)-15(n)]TJ 0 Tw (-)Tj 0.008 Tc 0.349 Tw -13.285 -1.25 Td [(ing fr)-32.7(amew)-13.7(or)-23.7(k in p)25.3(r)-23.7(edic)-15.7(t)-31.7(ing t)-12.7(he sur)-31.7(v)-15.7(i)-15.7(v)-14.7(al of col)30.3(or)-23.7(ec)-15.7(t)15.3(al cancer)8( )]TJ 0 Tc 0 Tw T* [(p)32(a)15(t)-32(ients. )]TJ /T1_2 1 Tf 0.218 Tw 4.055 0 Td [(Com)16(put Biol Med.)]TJ /T1_1 1 Tf [( 2022 Jul;146:105516. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1016/j.)Tj -4.055 -1.25 Td [(com)10(pbiomed.2022.105516)]TJ 0 0 0 1 k /GS1 gs 0.011 Tc 0.417 Tw T* (38.)Tj /Span<>> BDC ( )Tj EMC 1.841 0 Td [(Sp)31.7(ad)41.7(a)-17.2(cc)-24.2(ini)]TJ /Span<>> BDC ( )Tj EMC [(M, Bour)-24.2(k)9.8(e)]TJ /Span<>> BDC ( )Tj EMC [(MJ, Masell)-31.2(i)]TJ /Span<>> BDC ( )Tj EMC [(R, e)-12.3(t)]TJ /Span<>> BDC ( )Tj EMC [(al. ESD W)21.7(ester)-15.2(n)11( )]TJ 0 Tc 0.165 Tw -1.841 -1.25 Td [(All)-31(iance $EW)31(A$. Cl)-30.9(inical outcome of non-cur)-33(a)15(t)-32(i)-15.9(ve end)-16(oscopic sub)]TJ 0 Tw (-)Tj 0.008 Tc 0.349 Tw T* [(mucosal dissec)-15.8(t)-31.8(ion for ear)-29.8(l)35.2(y col)30.3(or)-23.7(ec)-15.7(t)15.1(al cancer. )]TJ /T1_2 1 Tf -0.008 Tw (Gut.)Tj /T1_1 1 Tf 0.349 Tw [( 2022 Jan)8( )]TJ 0 Tc 0.023 Tw T* [(20:gutjnl-2020-323897. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1136/gutjnl-2020-323897)Tj 0 0 0 1 k /GS1 gs 0.271 Tw T* (39.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Jin)Tj /Span<>> BDC ( )Tj EMC (J, Zhou)Tj /Span<>> BDC ( )Tj EMC (H, Sun)Tj /Span<>> BDC ( )Tj EMC [(S, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Super)-32(v)-15.9(ised lear)-15(ning based sy)-13(s)]TJ 0 Tw (-)Tj 0.112 Tw -1.796 -1.25 Td [(temic infl)-15.9(amma)15(t)17(or)-24(y mar)-23.9(k)10(er)-10(s enable a)-17(ccur)-33(a)15(te addi)-23.9(t)-32(ional sur)-32(ger)-23.9(y for )]TJ 0.082 Tw T* [(pT1NxM0 col)30(or)-23.9(ec)-16(t)15(al cancer: a com)10(p)32(ar)-33(a)15(t)-32(i)-16(ve anal)35(y)-13(sis of t)-31.9(w)-14(o p)25(r)-32.9(a)-17(c)-16(t)-32(ical )]TJ 0.241 Tw T* [(p)25(r)-24(edic)-15.9(t)-32(ion models for l)35(ym)10(ph node me)-11.9(t)15(ast)15(asis. )]TJ /T1_2 1 Tf [(Cancer Manag R)21(es)]TJ /T1_1 1 Tf 0 Tw (. )Tj 0.023 Tw T* [(2021;13:8967\2268977. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.2147/cmar.S337516)Tj 0 0 0 1 k /GS1 gs 0.305 Tw T* (40.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Ichimasa)Tj /Span<>> BDC ( )Tj EMC [(K, Nak)-17(ahar)-32.9(a)]TJ /Span<>> BDC ( )Tj EMC [(K, K)25(ud)-15.9(o)]TJ /Span<>> BDC ( )Tj EMC [(SE, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. N)-13.9(ovel \236r)-24(esec)-16(t and )]TJ 0.341 Tw -1.796 -1.25 Td [(anal)35(y)-13(sis\237 )0.6(app)25(r)-32(oa)-17(ch )0.6(for )0.5(T2 )0.6(col)30(or)-24(ec)-16(t)15(al )0.6(cancer )0.6(wi)-24(t)-13(h )0.6(use )0.5(of )0.6(ar)-22(t)-32(if)-28(i)]TJ 0 Tw (-)Tj 0.163 Tw T* [(c)-24(ial intell)-30.9(igence. )]TJ /T1_2 1 Tf (Gastrointest Endosc)Tj /T1_1 1 Tf [(. 2022 O)-16(c)-16(t;96$4$:665\226672.e1. )]TJ 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1016/j.gie.2022.04.1305)Tj 0 0 0 1 k /GS1 gs 0.152 Tw -1.847 -1.25 Td (41.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(K)-16(ang)]TJ /Span<>> BDC ( )Tj EMC 2.4 0 Td [(J, )0.5(Choi)]TJ /Span<>> BDC ( )Tj EMC 3.17 0 Td [(Y)15(J, )0.5(Kim)]TJ /Span<>> BDC ( )Tj EMC 3.389 0 Td [(IK, )0.5(e)-12(t)]TJ /Span<>> BDC ( )Tj EMC 2.677 0 Td [(al. )0.5(L)-35(A)35(S)17(SO-Based )0.6(Ma)-17(chine )0.5(L)35(ear)-15(ning )]TJ 0.084 Tw -13.432 -1.25 Td [(Al)16(gor)-37(i)-23.9(t)-13(hm for P)35(r)-24(edic)-16(t)-32(ion of L)70(ym)10(ph N)-14(ode Me)-11.9(t)15(ast)15(asis in T1 Col)30(or)-23.9(ec)-16(t)15(al )]TJ 0 Tw T* (Cancer. )Tj /T1_2 1 Tf 0.24 Tw 3.436 0 Td [(Cancer )0.6(R)21(es )0.6(T)56(reat.)]TJ /T1_1 1 Tf [( )0.6(2021 )0.6(Jul;53$3$:773\226783. )0.6(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw 20.462 0 Td (10.4143/)Tj -23.899 -1.25 Td [(cr)-22(t.2020.974)]TJ 0 0 0 1 k /GS1 gs 0.15 Tw T* (42.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(S)-16(o)-16(guer)-32(o-Ruiz)]TJ /Span<>> BDC ( )Tj EMC [(C, Hindber)-32(g)]TJ /Span<>> BDC ( )Tj EMC [(K, M)-23.9(or)-33(a-Jim\351nez)]TJ /Span<>> BDC ( )Tj EMC [(I, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. P)35(r)-24(edic)-16(t)-32(ing )]TJ 0.01 Tc 0.364 Tw -1.796 -1.25 Td [(col)30.3(or)-23.8(ec)-15.7(t)15.2(al sur)-31.7(gical com)10.3(pl)-30.7(ica)15.3(t)-31.7(ions using he)-11.7(ter)-31.7(o)-15.8(geneous cl)-30.8(inical)10( )]TJ 0 Tc 0.256 Tw T* [(d)42(a)15(t)15(a and k)10(er)-15(nel me)-12(t)-13(hods. )]TJ /T1_2 1 Tf [(J Biomed Infor)-13.9(m)]TJ /T1_1 1 Tf (. 2016 Jun;61:87\22696. )Tj 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1016/j.jbi.2016.03.008)Tj 0 0 0 1 k /GS1 gs 0.086 Tw -1.847 -1.25 Td (43.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(L)-32(in)]TJ /Span<>> BDC ( )Tj EMC [(V, T)60(souchnik)-17(a)]TJ /Span<>> BDC ( )Tj EMC [(A, All)-16(akhver)-23.9(di)-16(iev)]TJ /Span<>> BDC ( )Tj EMC [(E, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. T)50(r)-33(aining p)25(r)-24(edic)-15.9(t)-32(ion )]TJ 0.231 Tw -1.796 -1.25 Td [(models for indi)-16(v)-15.9(idual r)-37(isk assess)26(ment of post)17(oper)-33(a)15(t)-32(i)-16(ve com)10(pl)-31(ica)]TJ 0 Tw (-)Tj 0.296 Tw T* [(t)-32(ions af)-27.9(ter sur)-32(ger)-24(y for col)30(or)-24(ec)-16(t)15.1(al cancer. )]TJ /T1_2 1 Tf [(T)54(ech Colop)46.1(roctol)]TJ /T1_1 1 Tf (. 2022 )Tj 0.023 Tw T* [(A)10(ug;26$8$:665\226675. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1007/s10151-022-02624-x)Tj 0 0 0 1 k /GS1 gs 0.008 Tc 0.349 Tw T* [(44)0.5(.)]TJ /Span<>> BDC ( )Tj EMC 1.826 0 Td [(Ru)0.5(an)]TJ /Span<>> BDC ( )Tj EMC [(X)0.5(, F)10.5(u)]TJ /Span<>> BDC ( )Tj EMC [(S, S)15.4(t)17.5(or)-29.5(l)-30.6(ie)]TJ /Span<>> BDC 9.428 0 Td ( )Tj EMC [(CB,)0.5( e)-11.5(t)]TJ /Span<>> BDC ( )Tj EMC [(al.)0.5( R)13.4(eal)0.5(-t)-31.5(im)0.5(e r)-36.5(is)0.5(k p)25.4(r)-23.5(edi)0.5(c)-15.6(t)-31.6(i)0.5(on)8( )]TJ 0.009 Tc -11.254 -1.25 Td [(of col)30.1(or)-23.9(ec)-16(t)15.1(al sur)-31.9(ger)-23.9(y-r)-23.9(el)-15.9(a)15.1(ted post-sur)-31.9(gical com)10(pl)-30.9(ica)15.1(t)-32(ions using)9( )]TJ 0 Tc 0.151 Tw T* [(GR)12(U-D model. )]TJ /T1_2 1 Tf [(J Biomed Infor)-13.9(m)]TJ /T1_1 1 Tf [(. 2022;135:104202. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1016/j.)Tj T* (jbi.2022.104202)Tj 0 0 0 1 k /GS1 gs 0.128 Tw T* (45.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(K)25(eane)]TJ /Span<>> BDC ( )Tj EMC [(C, W)22(ells)]TJ /Span<>> BDC ( )Tj EMC [(C, O\254G)20(r)-33(ad)17(y)]TJ /Span<>> BDC ( )Tj EMC [(G, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Def)-28(ining l)30(o)-14(w anter)-36.9(ior r)-24(esec)]TJ 0 Tw (-)Tj 0.275 Tw -1.796 -1.25 Td [(t)-32(ion )0.5(syndr)-31.9(ome: )0.5(a )0.5(sy)-12.9(stema)15(t)-32(ic )0.5(r)-23.9(ev)-16(iew )0.5(of )0.5(t)-12.9(he )0.5(l)-31(i)-24(ter)-32.9(a)15(tur)-24(e. )]TJ /T1_2 1 Tf 23.7 0 Td [(Color )0.6(Dis.)]TJ /T1_1 1 Tf 0 Tw ( )Tj -23.7 -1.25 Td (2017;19$8$:713)Tj /Span<>> BDC (-)Tj EMC (722.)Tj 0.008 Tw T* (46.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Huang)Tj /Span<>> BDC ( )Tj EMC 2.851 0 Td [(MJ, )0.5(Y)30(e)]TJ /Span<>> BDC ( )Tj EMC 2.702 0 Td [(L, )0.5(Y)35(u)]TJ /Span<>> BDC ( )Tj EMC 2.074 0 Td [(KX, )0.5(e)-12(t)]TJ /Span<>> BDC ( )Tj EMC 2.496 0 Td [(al. )0.5(Devel)30(opment )0.5(of )0.6(p)25(r)-24(edic)-16(t)-32(ion )0.5(model )0.5(of )]TJ 0.059 Tw -11.919 -1.25 Td [(l)30(o)-14(w anter)-37(ior r)-24(esec)-16(t)-31.9(ion syndr)-31.9(ome for col)30(or)-24(ec)-15.9(t)15(al cancer p)32(a)15(t)-32(ients af)-28(ter )]TJ 0.255 Tw T* [(sur)-32(ger)-23.9(y based on ma)-16.9(chine-lear)-15(ning )0.5(technique. )]TJ /T1_2 1 Tf [(Cancer )0.5(Med.)]TJ /T1_1 1 Tf ( 2023 )Tj 0.023 Tw T* [(Jan;12$2$:1501\2261519. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1002/cam4.5041)Tj 0 0 0 1 k /GS1 gs 0.298 Tw T* (47.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Chen)Tj /Span<>> BDC ( )Tj EMC 2.503 0 Td [(KA, )0.5(Joisa)]TJ /Span<>> BDC ( )Tj EMC [(CU, )0.5(S)15(t)-32(i)-24(tzenber)-31.9(g)]TJ /Span<>> BDC ( )Tj EMC [(KB, )0.5(e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. )0.5(Devel)30(opment )0.5(and )]TJ 0.057 Tw -4.299 -1.25 Td [(V)25(al)-31(id)42(a)15(t)-32(ion )0.5(of )0.5(Ma)-16.9(chine )0.5(L)35(ear)-15(ning )0.5(M)-24(odels )0.5(t)17(o )0.5(P)35(r)-24(edic)-15.9(t )0.5(R)13(eadmission )0.5(Af)-28(ter )]TJ -0.017 Tw T* [(Col)30(or)-23.9(ec)-16(t)15(al )0.5(Sur)-32(ger)-24(y. )]TJ /T1_2 1 Tf 7.82 0 Td [(J )0.5(Gastrointest )0.5(Surg.)]TJ /T1_1 1 Tf [( )0.5(2022 N)-14(ov;26$11$:2342\2262350. )]TJ 0 Tw -7.82 -1.25 Td [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1007/s11605-022-05443-5)Tj 0 0 0 1 k /GS1 gs 0.052 Tw -1.847 -1.25 Td (48.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Zhou)Tj /Span<>> BDC ( )Tj EMC (N, Zhang)Tj /Span<>> BDC ( )Tj EMC [(CT, L)50(v)]TJ /Span<>> BDC ( )Tj EMC [(HY, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. 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Gl)30(obal Cancer S)15(t)15(a)15(t)-31.9(ist)-32(ics 2020: )]TJ 0.17 Tw -1.296 -1.25 Td [(GL)35(OBOC)20(A)51(N Est)-32(ima)15.1(tes of Inc)-24(idence and M)-24(or)-22(t)15(al)-31(i)-23.9(t)-10(y W)20(or)-30(ld)-17(wide for 36 )]TJ 0.003 Tw 0 -1.25 TD [(Cancer)-10(s in 185 Countr)-37(ies. C)20(A )]TJ /T1_1 1 Tf (Cancer J Clin.)Tj /T1_0 1 Tf [( 2021 Ma)15(y;71$3$:209\226249. )]TJ 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td [(10.3322/caa)-17(c.21660)]TJ 0 0 0 1 k /GS1 gs 0.102 Tw -1.847 -1.25 Td (2.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (Jin)Tj /Span<>> BDC ( )Tj EMC [(Z, S)-16(inicr)-31.9(ope)]TJ /Span<>> BDC ( )Tj EMC [(F)24(A. Mis)26(ma)15(tch r)-24(ep)32(air-def)-28(ic)-24(ient col)30(or)-23.9(ec)-16(t)15(al cancer: )]TJ 0.071 Tw -1.296 -1.25 Td [(building on checkpoint bl)30(o)-16(ck)-16.9(ade. )]TJ /T1_1 1 Tf (J Clin Oncol)Tj /T1_0 1 Tf (. 2022;40:2735\2262750. )Tj 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1200/jco.21.02691)Tj 0 0 0 1 k /GS1 gs -0.052 Tw -1.847 -1.25 Td (3.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(L)-32(in)]TJ /Span<>> BDC ( )Tj EMC [(PS, Semr)-33(ad)]TJ /Span<>> BDC ( )Tj EMC [(T)25(J. M)-24(olecul)-15.9(ar test)-32(ing for t)-13(he tr)-24(ea)15(tment of ad)-16.9(v)-15(anced )]TJ 0.154 Tw -1.296 -1.25 Td [(col)30(or)-24(ec)-15.9(t)15(al cancer: an over)-32(v)-16(iew. )]TJ /T1_1 1 Tf (Methods Mol Biol)Tj /T1_0 1 Tf (. 2018;1765:281\226)Tj 0.023 Tw T* [(297. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1007/978-1-4939-7765-9_18)Tj 0 0 0 1 k /GS1 gs 0.14 Tw T* (4.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Y)-29(in)]TJ /Span<>> BDC ( )Tj EMC [(X, L)-32(iao)]TJ /Span<>> BDC ( )Tj EMC [(H, Y)35(un)]TJ /Span<>> BDC ( )Tj EMC [(H, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Ar)-22(t)-32(if)-28(ic)-23.9(ial intell)-31(igence-based p)25(r)-23.9(edic)]TJ 0 Tw (-)Tj 0.204 Tw -1.296 -1.25 Td [(t)-32(ion of cl)-30.9(inical outcome in immuno)17.1(t)-13(her)-33(apy and t)15.1(ar)-32(ge)-12(ted t)-13(her)-33(apy )]TJ 0.298 Tw T* [(of l)35(ung cancer. )]TJ /T1_1 1 Tf (Semin Cancer Biol.)Tj /T1_0 1 Tf [( 2022 N)-14(ov;86$P)15(t 2$:146\226159. )]TJ 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1016/j.semcancer.2022.08.002)Tj 0 0 0 1 k /GS1 gs 0.049 Tw -1.847 -1.25 Td (5.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Mi)-24(tsal)-15.9(a)]TJ /Span<>> BDC ( )Tj EMC [(A, T)60(sal)-30.9(ik)-16(idis)]TJ /Span<>> BDC ( )Tj EMC [(C, P)-24(i)-24(t)-31.9(iakoudis)]TJ /Span<>> BDC ( )Tj EMC [(M, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Ar)-22(t)-32(if)-28(ic)-23.9(ial intell)-31(igence )]TJ 0.072 Tw -1.296 -1.25 Td [(in col)30(or)-23.9(ec)-16(t)15(al cancer scr)-23.9(eening, dia)-17(gnosis and tr)-24(ea)15(tment. A new er)-33(a. )]TJ /T1_1 1 Tf 0.023 Tw T* [(Cur)-16(r Oncol)]TJ /T1_0 1 Tf [(. 2021;28:1581\2261607. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw [(10.3390/cur)-24(r)-31.9(oncol28030149)]TJ 0 0 0 1 k /GS1 gs 0.124 Tw T* (6.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(T)50(r)-33(an)]TJ /Span<>> BDC ( )Tj EMC [(KA, K)25(ondr)-33(ashov)-15(a)]TJ /Span<>> BDC ( )Tj EMC [(O, Br)-33(adle)-10.9(y)]TJ /Span<>> BDC ( )Tj EMC [(A, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Deep lear)-15(ning in can)]TJ 0 Tw (-)Tj 0.338 Tw -1.296 -1.25 Td [(cer dia)-17(gnosis, p)25(r)-32(o)-16(gnosis and tr)-23.9(ea)15(tment selec)-16(t)-31.9(ion. )]TJ /T1_1 1 Tf (Genome Med)Tj /T1_0 1 Tf 0 Tw (. )Tj 0.023 Tw T* [(2021;13:152. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1186/s13073-021-00968-x)Tj 0 0 0 1 k /GS1 gs 0.162 Tw T* (7.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Y)50(ang)]TJ /Span<>> BDC ( )Tj EMC [(R, Y)35(u)]TJ /Span<>> BDC ( )Tj EMC [(Y. Ar)-22(t)-32(if)-28(ic)-23.9(ial convol)35.1(ut)-32(ional neur)-33(al ne)-12(t)-32(w)-14(or)-23.9(k in objec)-16(t )]TJ 0.056 Tw -1.296 -1.25 Td [(de)-12(tec)-16(t)-31.9(ion and semant)-32(ic segment)15.1(a)15(t)-32(ion for )0.5(medical ima)-17(ging anal)35(y)-12.9(sis. )]TJ /T1_1 1 Tf 0.023 Tw T* [(F)27(ront Oncol)]TJ /T1_0 1 Tf [(. 2021;11:638182. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.3389/fonc.2021.638182)Tj 0 0 0 1 k /GS1 gs 0.024 Tw T* (8.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (\215\026\030\026\n\017\027)Tj /Span<>> BDC ( )Tj EMC (\205.\203., \025\026\022\024\021\022\017\027)Tj /Span<>> BDC ( )Tj EMC (\200.\200., \207\031\030\022\017\027)Tj /Span<>> BDC ( )Tj EMC (\212.\202., \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. \217\026\007\017\024\n\017\022\026 )Tj 0.014 Tc 0.509 Tw -1.296 -1.25 Td (\017)Tj /Span<>> BDC ( )Tj EMC 1.287 0 Td [(\017\f\022\031\f\f\021\r\036\027\027\t\005 )0.6(\017\027\021\036\035\035\036\022\021 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 13.405 0 Td [(\007\017\235\235\036\030\036\027\006\017\026\035\034\027\024\005 )0.5(\007\017\026\020\027\024\f)]TJ 0 Tc 0 Tw (-)Tj 0.012 Tc 0.425 Tw -14.693 -1.25 Td [(\021)0.5(\017)0.5(\022)0.5(\036)0.5( \024)0.5(\023)0.5(\031)0.5(\b)0.5(\024)0.5(\035)0.5(\036)0.5(\r)0.5(\t)0.5(\b)0.5( \017)]TJ /Span<>> BDC ( )Tj EMC [(\027)0.5(\036)0.5(\024)0.5(\023)0.5(\031)0.5(\b)0.5(\024)0.5(\035)0.5(\036)0.5(\r)0.5(\t)0.5(\b)0.5( )0.5(\026)0.5(\002)0.5(\024)0.5(\035)0.5(\036)0.5(\r)0.5(\026)0.5(\027)0.5(\017)0.5(\005)0.5( \023)0.5(\024)0.5(\007)0.5(\032)0.5(\036)0.5(\035)0.5(\031)0.5(\007)0.5(\024)0.5(\004)]TJ 0 Tc 0 Tw 27.286 0 Td (-)Tj 0.269 Tw -27.286 -1.25 Td (\027\024\005 \032\036\035\036\t $\024\002\024\030$. )Tj /T1_1 1 Tf (\224\022\033\023\033\013\022\201\016\024\021\037\030 \f\033\037\021\035\022\ \021\037)Tj /T1_0 1 Tf (. 2023;$1$:53\22665. )Tj 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.952 0 Td (10.38181/2223-2427-2023-1-5)Tj 0 0 0 1 k /GS1 gs 0.128 Tw [( / P)40(ar)-33(amzin)]TJ /Span<>> BDC ( )Tj EMC [(F.N., K)-16(ako)17(tk)-16(in)]TJ /Span<>> BDC ( )Tj EMC (V.V., )Tj 0.336 Tw -1.952 -1.25 Td [(Bur)-24(k)-15.9(in)]TJ /Span<>> BDC ( )Tj EMC [(D.A., e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. R)-10(adiomics and ar)-22(t)-32(if)-27.9(ic)-24(ial intell)-30.9(igence in t)-13(he )]TJ 0.349 Tw T* [(dif)-56(fer)-23.9(ent)-32(ial dia)-17(gnosis of tumor and non-tumor diseases of t)-13(he )]TJ 0.343 Tw T* [(p)32(ancr)-24(eas. R)13(ev)-16(iew.)]TJ /T1_1 1 Tf [( Surgical p)46(ractice.)]TJ /T1_0 1 Tf ( 2023;$1$:53\22665. $In Russ.$. )Tj 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.38181/2223-2427-2023-1-5)Tj 0 0 0 1 k /GS1 gs -0.035 Tw -1.847 -1.25 Td (9.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(L)-32(i)]TJ /Span<>> BDC ( )Tj EMC (M, Xiao)Tj /Span<>> BDC ( )Tj EMC [(Q, V)30(enk)-17(a)15(t)15(a)-17(chal)-15.9(am)]TJ /Span<>> BDC ( )Tj EMC [(N, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. P)35(r)-24(edic)-16(t)-32(ing r)-23.9(esponse t)17(o neoad)]TJ 0 Tw (-)Tj -0.029 Tw -1.296 -1.25 Td [(juv)-15(ant )0.5(chemor)-33(adio)17.1(t)-13(her)-33(apy )0.5(in )0.5(r)-24(ec)-16(t)15(al )0.5(cancer: )0.5(fr)-32(om )0.5(biomar)-24(k)10(er)-9.9(s t)17(o )0.5(tumor )]TJ 0 Tw T* (models. )Tj /T1_1 1 Tf 0.135 Tw 3.5 0 Td [(Ther Adv )0.5(Med Oncol. 2022)]TJ /T1_0 1 Tf [( F)10(eb )0.5(21;14:17588359221077972. )]TJ 0 Tw -3.5 -1.25 Td [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1177/17588359221077972)Tj 0 0 0 1 k /GS1 gs 0.107 Tw -1.847 -1.25 Td (10.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Maas)Tj /Span<>> BDC ( )Tj EMC (M, Nelemans)Tj /Span<>> BDC ( )Tj EMC [(P)35(J, V)25(alent)-31.9(ini)]TJ /Span<>> BDC ( )Tj EMC [(V, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. L)35(ong-ter)-16(m outcome in )]TJ -0.021 Tw 27.259 45 Td [(p)32(a)15(t)-32(ients wi)-24(t)-12.9(h a p)32(a)15(t)-13(hol)30(o)-16(gical com)10(ple)-11.9(te r)-23.9(esponse af)-28(ter chemor)-33(adia)15(t)-32(ion )]TJ 0.015 Tw T* [(for r)-24(ec)-16(t)15.1(al cancer: a po)-15.9(oled anal)35(y)-13(sis of indi)-16(v)-16(idual p)32(a)15(t)-31.9(ient d)41.9(a)15(t)15(a. )]TJ /T1_1 1 Tf 0 Tw (Lancet )Tj T* (Oncol. )Tj /T1_0 1 Tf -0.031 Tw 2.664 0 Td [(2010 Sep;11$9$:835\22644. d)-15.9(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1016/S1470-2045$10$70172-)Tj -2.664 -1.25 Td (8)Tj 0 0 0 1 k /GS1 gs 0.104 Tw T* (11.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(L)-32(i)]TJ /Span<>> BDC ( )Tj EMC (C, Chen)Tj /Span<>> BDC ( )Tj EMC (L, Chou)Tj /Span<>> BDC ( )Tj EMC [(C, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Using ma)-17(chine lear)-14.9(ning app)25(r)-32(oa)-17(ches )]TJ 0.253 Tw -1.796 -1.25 Td [(t)17(o p)25(r)-23.9(edic)-16(t shor)-22(t-ter)-15.9(m r)-36.9(isk of car)-24(dio)17(t)17(o)14(xic)-24(i)-24(t)-9.9(y among p)32(a)15(t)-32(ients wi)-24(t)-12.9(h )]TJ 0.009 Tc 0.349 Tw T* [(col)30.2(or)-23.9(ec)-15.9(t)15.1(al cancer af)-27.9(ter st)15.1(ar)-21.8(t)-31.9(ing fl)35.2(uor)-31.8(opyr)-36.8(imidine-based chemo)]TJ 0 Tc 0 Tw (-)Tj T* [(t)-13(her)-32.9(apy. )]TJ /T1_1 1 Tf 0.005 Tw 3.643 0 Td [(Cardiov)16.1(asc T)53(o)14(xicol)]TJ /T1_0 1 Tf [(. 2022;22:130\226140. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1007/s12012-)Tj -3.643 -1.25 Td (021-09708-4)Tj 0 0 0 1 k /GS1 gs 0.242 Tw T* (12.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Oy)22(a)-17(ga-Ir)-37(iar)-21.9(te)]TJ /Span<>> BDC ( )Tj EMC [(E, Insaust)-32(i)]TJ /Span<>> BDC ( )Tj EMC [(A, Sa)15(y)22(ar)]TJ /Span<>> BDC ( )Tj EMC [(O, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. P)35(r)-23.9(edic)-16(t)-32(ion of ir)-37(i)]TJ 0 Tw (-)Tj 0.333 Tw -1.796 -1.25 Td [(no)17(tecan t)17(o)14(xic)-24(i)-23.9(t)-10(y in me)-11.9(t)15(ast)15(a)15(t)-32(ic col)30(or)-24(ec)-16(t)15(al cancer p)32(a)15(t)-32(ients based )]TJ 0.225 Tw T* [(on ma)-17(chine lear)-15(ning models wi)-24(t)-13(h phar)-16(ma)-17(cok)-15.9(ine)-12(t)-32(ic p)32(ar)-33(ame)-12(ter)-9.9(s. )]TJ /T1_1 1 Tf 0 Tw (J )Tj 0.023 Tw T* [(Phar)-14(macol Sci)]TJ /T1_0 1 Tf [(. 2019;140:20\22625. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1016/j.jphs.2019.03.004)Tj 0 0 0 1 k /GS1 gs 0.329 Tw T* (13.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Bibaul)56(t)]TJ /Span<>> BDC ( )Tj EMC [(JE, Gir)-33(aud)]TJ /Span<>> BDC ( )Tj EMC [(P, Housse)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(M, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Deep L)35(ear)-15(ning and )]TJ 0.28 Tw -1.796 -1.25 Td [(R)-10(adiomics p)25(r)-24(edic)-16(t com)10(ple)-12(te r)-24(esponse af)-28(ter neo-ad)17(juv)-15(ant chemo)]TJ 0 Tw (-)Tj 0.295 Tw T* [(r)-33(adia)15(t)-31.9(ion )0.5(for )0.6(l)30(o)-16(call)35(y )0.5(ad)-16.9(v)-15(anced )0.5(r)-24(ec)-15.9(t)15(al )0.5(cancer. )]TJ /T1_1 1 Tf 19.664 0 Td [(Sci )0.6(R)21(ep)]TJ /T1_0 1 Tf [(. )0.5(2018 )0.6(A)10(ug )]TJ 0.023 Tw -19.664 -1.25 Td [(22;8$1$:12611. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1038/s41598-018-30657-6)Tj 0 0 0 1 k /GS1 gs 0.002 Tc 0.349 Tw T* [(1)0.5(4)0.5(.)]TJ /Span<>> BDC 1.301 0 Td ( )Tj EMC 0.502 0 Td [(G)0.5(i)0.5(a)0.5(n)0.5(ni)0.5(n)0.5(i)]TJ /Span<>> BDC 3.406 0 Td ( )Tj EMC [(V)0.5(,)0.5( P)20.5(u)0.5(s)0.5(c)0.5(e)0.5(dd)0.5(u)]TJ /Span<>> BDC 5.688 0 Td ( )Tj EMC [(L)0.5(,)0.5( D)0.5(e)0.5(f)0.5(e)0.5(u)0.5(d)0.5(i)0.5(s)]TJ /Span<>> BDC ( )Tj EMC [(A)0.5(, e)-11.5(t)]TJ /Span<>> BDC 8.047 0 Td ( )Tj EMC [(a)0.5(l)0.5(.)0.5( D)0.5(e)0.5(l)56.5(t)15.5(a)0.5(-)0.5(R)-9.5(ad)0.5(i)0.5(o)0.5(m)0.5(i)0.5(c)0.5(s)2( )]TJ 0 Tc 0.132 Tw -18.943 -1.25 Td [(P)35(r)-24(edic)-15.9(ts R)13(esponse )0.5(t)17(o )0.5(F)-19(ir)-10(st-L)-31.9(ine )0.5(Ox)-11(al)-31(ipl)-16(a)15.1(t)-32(in-Based )0.5(Chemo)17(t)-13(her)-33(apy )0.5(in )]TJ 0.193 Tw T* [(Col)30(or)-23.9(ec)-16(t)15(al Cancer P)40(a)15(t)-32(ients wi)-23.9(t)-13(h L)-32(i)-16(ver Me)-12(t)15(ast)15(ases. )]TJ /T1_1 1 Tf (Cancers $Basel$.)Tj /T1_0 1 Tf 0 Tw ( )Tj 0.023 Tw T* [(2022 Jan 4;14$1$:241. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw [(10.3390/cancer)-9.9(s14010241)]TJ 0 0 0 1 k /GS1 gs 0.108 Tw T* (15.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Gal)30(on)]TJ /Span<>> BDC ( )Tj EMC 2.588 0 Td [(J, )0.5(Br)-22(uni)]TJ /Span<>> BDC ( )Tj EMC 3.516 0 Td [(D. )0.5(App)25(r)-32(oa)-17(ches )0.5(t)17(o )0.5(tr)-23.9(ea)15(t )0.5(immune )0.5(ho)17(t, )0.5(al)56(ter)-23.9(ed and )]TJ 0.315 Tw -7.9 -1.25 Td [(cold tumour)-10(s wi)-24(t)-13(h combina)15(t)-32(ion immuno)17.1(t)-13(her)-33(apies. )]TJ /T1_1 1 Tf [(N)18(at R)21.1(ev Drug )]TJ 0 Tw T* (Discov)Tj /T1_0 1 Tf 0.023 Tw [(. 2019;18$3$:197\2268. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1038/s41573-018-0007-y)Tj 0 0 0 1 k /GS1 gs 0.145 Tw T* (16.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Angell)Tj /Span<>> BDC ( )Tj EMC [(HK, Br)-21.9(uni)]TJ /Span<>> BDC ( )Tj EMC [(D, Bar)-24(r)-24(e)-12(t)-29.9(t)]TJ /Span<>> BDC ( )Tj EMC [(JC, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. T)47(he Immunoscor)-23.9(e: Col)30(on )]TJ 0.199 Tw -1.796 -1.25 Td [(Cancer )0.5(and )0.5(Be)-10.9(yond. )]TJ /T1_1 1 Tf 8.728 0 Td [(Clin )0.5(Cancer )0.6(R)21(es.)]TJ /T1_0 1 Tf [( )0.5(2020 )0.5(Jan )0.5(15;26$2$:332\226339. )]TJ 0 Tw -8.728 -1.25 Td [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1158/1078-0432.CCR-18-1851)Tj 0 0 0 1 k /GS1 gs 0.021 Tw -1.847 -1.25 Td (17.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(F)10(oer)-10(sch)]TJ /Span<>> BDC ( )Tj EMC [(S, Gl)-15.9(asner)]TJ /Span<>> BDC ( )Tj EMC [(C, W)20(oer)-30(l)]TJ /Span<>> BDC ( )Tj EMC [(A)16(C, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Mul)56(t)-32(ist)15(ain deep lear)-14.9(ning for )]TJ 0.121 Tw -1.796 -1.25 Td [(p)25(r)-24(edic)-15.9(t)-32(ion of p)25(r)-32(o)-16(gnosis and t)-12.9(her)-33(apy r)-23.9(esponse in col)30(or)-24(ec)-15.9(t)15(al cancer. )]TJ /T1_1 1 Tf -0.025 Tw T* [(N)18(at Med.)]TJ /T1_0 1 Tf [( 2023 F)10(eb;29$2$:430\226439. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1038/s41591-022-02134-)Tj T* (1)Tj 0 0 0 1 k /GS1 gs -0.018 Tw T* (18.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(McG)20(r)-33(anahan)]TJ /Span<>> BDC ( )Tj EMC [(N, F)9.9(ur)-14.9(ness)]TJ /Span<>> BDC ( )Tj EMC [(AJ, R)11(osent)-13(hal)]TJ /Span<>> BDC ( )Tj EMC [(R, e)-11.9(t)]TJ /Span<>> BDC ( )Tj EMC [(al. 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EMC (\f\035\031\004\026\036 \031\f\023\036\001\027\024\005 )Tj 0.17 Tw T* (\r\027\036\001\027\036\005 \r\026\035\017\007\026\006\017\017 \f\035\036\ \007\031\033\013\017\n \220\021\026\023\024\n \024\006\036\027\022\017 \220\ \235)Tj 0 Tw (-)Tj -0.027 Tw T* (\235\036\022\021\017\r\027\024\f\021\017 \023\030\024\007\031\022\021\026\ \007\024\035\032\027\026 \002\t\021\034 \220\022\f\023\036\030\021\027\026\ \016 \024\006\036\027)Tj 0 Tw (-)Tj 0.263 Tw T* [(\022\026. )0.5(\206\024\r\024\030\016 )0.5(\024)]TJ /Span<>> BDC ( )Tj EMC 6.089 0 Td [(\023\024\f\035\036\007\027\036\005, )0.6(\036\013\036 )0.5(\030\026 )0.5(\f\021\024\017\021 )0.5(\031\023\024\n\016\027\031\021\034 )]TJ 0.195 Tw -6.089 -1.218 Td [(W)12(a)15(tson for Oncol)30(o)-16(g)16(y $WfO$ [27,48]. \212\026\027\027\026\016 \f\017\f\021\036\n\026 )]TJ 0.168 Tw T* (\002\t\035\026 \030\026\030\026\002\024\021\026\027\026 \r)Tj /Span<>> BDC ( )Tj EMC (\225\221\202 \027\026)Tj /Span<>> BDC ( )Tj EMC (\024\f\027\024\r\036 \007\026\027\027\t\b \027\026\006\017\024)Tj 0 Tw (-)Tj 0.014 Tw T* [(\027\026\035\034\027\024\005 \022\024\n\023\035\036\022\f\027\024\005 \024\ \027\022\024\035\024\020\017\004\036\f\022\024\005 \f\036\021\017 $Na)15.1(t)-32(ional )]TJ -0.001 Tw T* [(Com)10(p)25(r)-24(ehensi)-15.9(ve Cancer Ne)-12(t)-32(w)-13.9(or)-24(k)]TJ /Span<>> BDC ( )Tj EMC (\227 NCCN$ \017)Tj /Span<>> BDC ( )Tj EMC (\002\t\035\026 \026\023\030\024)Tj 0 Tw (-)Tj -0.016 Tw T* (\002\017\030\024\r\026\027\026 \r)Tj /Span<>> BDC ( )Tj EMC [(\030\036\026\035\034\027\024\005 \022\035\017\027\017\004\036\f\022\024\005\ )0.5(\023\030\026\022\021\017\022\036 \r)]TJ /Span<>> BDC ( )Tj EMC (14)Tj /Span<>> BDC ( )Tj EMC (\030\026)Tj 0 Tw (-)Tj 0.464 Tw T* [(\035\017\004\027\t\b \f\021\030\026\027\026\b. )0.5(\225\031\021\034 \017\f\f\035\036\007\024\r\026\027\017\005 \026\022\035\ \033\004\026\035\026\f\034 )]TJ 0.125 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\021\024\n, \004\021\024 \020\030\031\023\023\026 \220\022\f\023\036\030\ \021\024\r \f\024\023\024\f\021\026\r\035\016\035\026 \035\036\004\036\002\ \027\t\036 )Tj 0.023 Tw T* [(\f\021\030\026\021\036\020\017\017 )0.5(WfO )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC 6.894 0 Td [(\023\030\024\020\030\026\n\n\t )0.5(\035\036\004\036\027\017\016 )0.6(\r\030\026\004\036\005)]TJ /Span<>> BDC ( )Tj EMC 11.636 0 Td [(\227 )0.5(\024\027\022\024)]TJ 0 Tw (-)Tj 0.102 Tw -18.531 -1.218 Td (\035\024\020\024\r \r)Tj /Span<>> BDC ( )Tj EMC (\017\031\004\026\036\n\024\n \030\036\020\017\024\027\036 \017)Tj /Span<>> BDC ( )Tj EMC [(\024\023\030\036\007\036\035\016\035\026 )0.5(\017\b \023\030\017\036\n)]TJ 0 Tw (-)Tj -0.006 Tw T* (\035\036\n\024\f\021\034 \007\035\016 \022\024\027\022\030\036\021\027\024\ \020\024 \023\026\006\017\036\027\021\026. \200)Tj /Span<>> BDC ( )Tj EMC (\231\026\017\035\026\027\007\036 \023\024\004\021\017 )Tj -0.034 Tw T* (187)Tj /Span<>> BDC ( )Tj EMC ($60%$ \017)Tj /Span<>> BDC ( )Tj EMC (313 \023\026\030 \035\036\004\036\027\017\016 \030\026\022\026 \n\024\035\ \024\004\027\024\005 \032\036\035\036\t, )Tj 0.086 Tw T* (\035\036\020\022\017\b, \021\024\035\f\021\024\005 \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\016\n\024\005 \022\017\001\022\017, \002\t\035\017 \017\007\036\ \027\021\017\004\027\t\n\017 )Tj 0.234 Tw T* (\017\035\017 \024\007\017\027\026\022\024\r\024 \023\030\017\036\n\035\036\ \n\t\n\017, \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\n 219)Tj /Span<>> BDC ( )Tj EMC ($70%$ )Tj 0.442 Tw T* (\021\036\030\026\023\036\r\021\017\004\036\f\022\017\b \r\026\030\017\026\ \027\021\024\r WfO \002\t\035\017 \017\007\036\027\021\017\004\027\t )Tj 0.23 Tw T* [(\017\035\017 \023\030\017\036\n\035\036\n\t \026\035\034\021\036\030\027\ \026\021\017\r\026\n\017 )0.5(\021\036\030\026\023\017\017, \023\030\017\027\016\021\024\005 )]TJ 0.029 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\022\035\017\027\017\022\036 [27]. \200)Tj /Span<>> BDC ( )Tj EMC (94)Tj /Span<>> BDC ( )Tj EMC ($30%$ \f\035\031\004\026\036\r \024\007\017\027 \017\035\017 \024\002\026\ \r\026)Tj 0 Tw (-)Tj 0.244 Tw T* (\030\017\026\027\021\026 \035\036\004\036\027\017\016 \002\t\035\017 \024\ \006\036\027\036\027\t \022\026\022 \027\036\023\030\017\036\n\035\036\n\ \t\036. )Tj -0.027 Tw T* (\224)Tj /Span<>> BDC ( )Tj EMC (32)Tj /Span<>> BDC ( )Tj EMC (\f\035\031\004\026\036\r, \022\024\020\007\026 \024\002\026 \r\026\030\017\ \026\027\021\026 WfO \017)Tj /Span<>> BDC ( )Tj EMC (\253\035\024\022\026\035\034\027\t\036\273 )Tj 0.046 Tw T* (\002\t\035\017 \023\030\017\036\n\035\036\n\t\n\017, WfO \002\t\035 \023\ \030\036\007\023\024\004\021\036\027 \r)Tj /Span<>> BDC ( )Tj EMC (18 \f\035\031\004\026)Tj 0 Tw (-)Tj 0.097 Tw T* (\016\b, \026)Tj /Span<>> BDC ( )Tj EMC (\035\024\022\026\035\034\027\t\036)Tj /Span<>> BDC ( )Tj EMC (\227 \r)Tj /Span<>> BDC ( )Tj EMC (14 \f\035\031\004\026\016\b. \215\030\017)Tj /Span<>> BDC ( )Tj EMC (\025\217\025 \027\026\002\035\033\007\026)Tj 0 Tw (-)Tj 0.044 Tw T* (\035\026\f\034 \f\026\n\026\016 \r\t\f\024\022\026\016 \007\024\035\016 \ \017\007\036\027\021\017\004\027\t\b \017\035\017 \024\007\017\027\026\022\ \024\r\024 )Tj 0.024 Tw T* (\023\030\017\036\n\035\036\n\t\b \n\036\021\024\007\024\r \035\036\004\036\ \027\017\016; \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\030\026\022\036 IV \f\021\026\007\017\017)Tj /Span<>> BDC ( )Tj EMC (\227 )Tj 0.026 Tw T* (\f\026\n\026\016 \027\017\022\026\016. \215\030\017)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\n \026\r\021\024\030\t, \027\036\f\n\024\021\030\016 \027\026\ )Tj /Span<>> BDC ( )Tj EMC (\024\002\027\026\007\036)Tj 0 Tw (-)Tj 0.25 Tw T* [(\032\017\r\026\033\013\017\036 )0.6(\030\036\031\035\034\021\026\021\t )0.5(\030\026\002\024\021\t )0.6(\f\017\f\021\036\n\t, )0.5(\f\021\026\r\016\021 )0.5(\030\016\007 )]TJ -0.025 Tw T* [(\r\024\023\030\024\f\024\r )0.5(\024)]TJ /Span<>> BDC ( )Tj EMC 4.803 0 Td [(\021\024\n, )0.5(\004\021\024 )0.6(\017\f\023\024\035\034\024\r\026\027\017\036 )0.6(\225\215\215\025\217 )0.5(\n\024\032\036\021 )0.5(\031\r\036)]TJ 0 Tw (-)Tj 0.244 Tw -4.803 -1.218 Td [(\035\017\004\017\021\034 \r\030\036\n\016, \f\024\007\036\030\032\026\021\ \034 )0.5(\031\f\021\026\030\036\r\001\031\033 \017\027\235\024\030\n\026\006\017\033\ )]TJ 0.037 Tw T* [(\017\035\017 )0.5(\017\020\027\024\030\017\030\024\r\026\021\034\f\016 )0.5(\r\030\026\004\026\n\017, )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC 13.34 0 Td [(\024\021\r\036\021\t )0.5(\027\026)]TJ /Span<>> BDC ( )Tj EMC 4.33 0 Td [(\220\021\017 )0.5(\r\024\023\030\024)]TJ 0 Tw (-)Tj 0.026 Tw -17.67 -1.218 Td (\f\t \n\024\020\031\021 \002\t\021\034 \023\024\035\031\004\036\027\t \021\ \024\035\034\022\024 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\r\036\007\036\027\017\017 \n\026\f)Tj 0 Tw (-)Tj 0.01 Tw T* (\001\021\026\002\027\t\b \017\f\f\035\036\007\024\r\026\027\017\005 \r)Tj /Span<>> BDC ( )Tj EMC (\007\026\027\027\024\005 \024\002\035\026\f\021\017 [27]. \207\024\035\036\ \036 )Tj 0.315 Tw T* (\030\026\027\027\036\036 \017\f\f\035\036\007\024\r\026\027\017\036 WfO \ \017)Tj /Span<>> BDC ( )Tj EMC (\025\017\021\026\016 \017\035\035\033\f\021\030\017\030\031\036\021 )Tj 0.006 Tw T* (\030\026\027\017\006\031 \r)Tj /Span<>> BDC ( )Tj EMC (\f\017\021\031\026\006\017\017 \f)Tj /Span<>> BDC ( )Tj EMC (\035\036\004\036\027\017\036\n \030\026\022\026 \n\036\032\007\031 \200\024\ \f\021\024\022\024\n )Tj 0.18 Tw 23.244 64.543 Td (\017)Tj /Span<>> BDC ( )Tj EMC (\003\026\023\026\007\024\n, \022\024\021\024\030\026\016 \023\030\024\016\ \r\035\016\036\021\f\016 \r)Tj /Span<>> BDC ( )Tj EMC (\253\002\024\035\034\001\036\n \024\023\t\021\036 )Tj 0.111 Tw T* [(\022\017\021\026\005\f\022\017\b \f\023\036\006\017\026\035\017\f\021\024\ \r )0.5(\r\f\035\036\007\f\021\r\017\036 \002\024\035\034\001\036\020\024 \022\024\ \035\017)]TJ 0 Tw (-)Tj 0.127 Tw T* (\004\036\f\021\r\026 \023\026\006\017\036\027\021\024\r\273, \024\021\f\031\ \021\f\021\r\017\036 \027\026)Tj /Span<>> BDC ( )Tj EMC (\030\t\027\022\036 \025\017\021\026\016 \030\016\007\026 )Tj 0.033 Tw T* (\b\017\n\017\024\023\030\036\023\026\030\026\021\024\r \017)Tj /Span<>> BDC ( )Tj EMC (\021.\007. \231\026\022\017\n \024\002\030\026\024\n, \007\036\035\026\036\ \021\f\016 \r\t)Tj 0 Tw (-)Tj 0.006 Tw T* (\r\024\007 \024)Tj /Span<>> BDC ( )Tj EMC (\002\036\031\f\035\024\r\027\024\005 \027\036\024\002\b\024\007\017\n\024\ \f\021\017 \r\027\036\007\030\036\027\017\016 \225\215\215\025\217, )Tj 0.117 Tw T* (\027\024 \f)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\034\001\017\n \031\030\024\r\027\036\n \035\024\022\026\035\ \017\026\006\017\017, \021\024 \036\f\021\034 \f\024\002\035\033)Tj 0 Tw (-)Tj 0.312 Tw 0 -1.218 TD (\007\036\027\017\036\n \r\f\036\b \024\f\024\002\036\027\027\024\f\021\036\ \005 \027\026\006\017\024\027\026\035\034\027\024\005 \f\017\f\021\036\n\ \t )Tj 0 Tw 0 -1.218 TD (\007\030\026\r\024\024\b\030\026\027\036\027\017\016 [48].)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 275.0305 603.0498 Tm [(\020)21(\026\027\r\242\224\034\022\031\034)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0 Tc 0.041 Tw 10 0 0 10 274.9606 578.6938 Tm [(\231\026\022\017\n )0.5(\024\002\030\026\024\n, )0.5(\027\026\f\021\024\016\013\017\005 )0.6(\031\030\024\r\036\027\034 )0.6(\030\026\r\017\021\017\016 )0.5(\006\017\235\030\024)]TJ 0 Tw (-)Tj -0.024 Tw T* (\r\t\b \021\036\b\027\024\035\024\020\017\005 \r)Tj /Span<>> BDC ( )Tj EMC (\024\027\022\024\035\024\020\017\017, \026)Tj /Span<>> BDC ( )Tj EMC (\017\n\036\027\027\024 \r)Tj /Span<>> BDC ( )Tj EMC (\035\036\004\036\027\017\017 \025\217\217, )Tj -0.017 Tw T* (\027\036 \023\024\r\024\035\016\036\021 \020\024\r\024\030\017\021\034 \ \024)Tj /Span<>> BDC ( )Tj EMC (\023\024\035\027\024\006\036\027\027\024\n \224\224, \f\023\024\f\024\002\ \027\024\n )Tj -0.03 Tw 0 -1.218 TD (\023\030\017\027\017\n\026\021\034 \030\036\001\036\027\017\016 \024)Tj /Span<>> BDC ( )Tj EMC (\035\036\004\036\027\017\017 \023\026\006\017\036\027\021\024\r \002\036\ \r\030\026\004\036\002)Tj 0 Tw (-)Tj 0 -1.218 TD (\027\024\020\024 \022\024\027\021\030\024\035\016.)Tj 0.213 Tw 0 -1.218 TD (\217\036\031\035\034\021\026\021\t \n\027\024\020\024\004\017\f\035\036\ \027\027\t\b \017\f\f\035\036\007\024\r\026\027\017\005 \023\030\017\r\036\ \035\017 )Tj 0.067 Tw 0 -1.218 TD (\022)Tj /Span<>> BDC ( )Tj EMC (\f\024\007\026\027\017\033 \024\021\007\036\035\034\027\t\b \023\030\024\ \020\030\026\n\n\027\t\b \023\030\024\007\031\022\021\024\r, \024\002\031\ )Tj 0 Tw (-)Tj -0.002 Tw 0 -1.218 TD (\004\036\027\027\t\b \027\026)Tj /Span<>> BDC ( )Tj EMC (\030\026\035\017\004\027\t\b \023\024)Tj /Span<>> BDC ( )Tj EMC (\022\026\004\036\f\021\r\031 \017)Tj /Span<>> BDC ( )Tj EMC (\022\024\035\017\004\036\f\021\r\031 \027\026\002\024)Tj 0 Tw (-)Tj 0.077 Tw 0 -1.218 TD (\030\026\b \007\026\027\027\t\b, \022\024\021\024\030\t\036 \f\023\024\f\ \024\002\027\t \023\024\007\f\022\026\026\021\034 \f\006\036\027\026\030\ \017\005 )Tj 0.144 Tw T* (\035\036\004\036\027\017\016 \027\026)Tj /Span<>> BDC ( )Tj EMC (\024\f\027\024\r\036 \023\030\024\020\027\024\027\t\b \n\024\007\036\035\ \036\005, \017, \023\024)Tj /Span<>> BDC ( )Tj EMC (\f\031\021\017, )Tj 0.036 Tw T* [(\016\r\035\016\033\013\017\b\f\016 )0.6(\023\024\n\024\013\027\017\022\026\n\017 )0.5(\r\030\026\004\026 )0.6(\f)]TJ /Span<>> BDC ( )Tj EMC [(\024\004\036\027\034 )0.6(\024\020\030\026\027\017\004\036\027)]TJ 0 Tw (-)Tj T* (\027\t\n \235\031\027\022\006\017\024\027\026\035\024\n.)Tj 0.02 Tc 0.139 Tw T* [(\213\013\036 \024\007\027\024\005 \024\f\024\002\036\027\027\024\f\021\034\ \033 \007\026\027\027\024\020\024 \220\021\026\023\026 \030\026\r\017\021\ \017\016)20( )]TJ 0.049 Tw T* (\224\224 \r)Tj /Span<>> BDC ( )Tj EMC (\035\036\004\036\027\017\017 \025\217\217 \016\r\035\016\036\021\f\016 \021\ \024, \004\021\024, \f)Tj /Span<>> BDC ( )Tj EMC (\024\007\027\024\005 \f\021\024\030\024)Tj 0 Tc 0 Tw (-)Tj 0.02 Tc -0.046 Tw T* (\027\t, \031)Tj /Span<>> BDC ( )Tj EMC (\017\f\f\035\036\007\024\r\026\021\036\035\036\005 \017\n\036\036\021\f\016\ \001\017\030\024\022\017\005 \n\026\f\f\017\r \007\026\027)Tj 0 Tc 0 Tw (-)Tj 0.02 Tc 0.23 Tw T* (\027\t\b \027\026)Tj /Span<>> BDC ( )Tj EMC [(\r\b\024\007\036 $\022\035\017\027\017\004\036\f\022\017\036, \030\036\027\ \021\020\036\027\024\035\024\020\017\004\036\f\022\017\036,)20( )]TJ 0.27 Tw T* (\017\n\n\031\027\024\035\024\020\017\004\036\f\022\017\036 \017)Tj /Span<>> BDC ( )Tj EMC (\021.\007.$, \017)Tj /Span<>> BDC ( )Tj EMC [(\024\002\255\036\n \220\021\017\b \007\026\027\027\t\b)20( )]TJ 0.309 Tw T* (\021\024\035\034\022\024 \031\r\036\035\017\004\017\r\026\036\021\f\016,\ \026)Tj /Span<>> BDC ( )Tj EMC [(\027\026 \r\t\b\024\007\036 \f\024\b\030\026\027\016\036\021\f\016)20( )]TJ 0.245 Tw T* [(\007\024\f\021\026\021\024\004\027\024 \031\022\017\005 \f\023\036\022\021\ \030 \022\035\017\027\017\004\036\f\022\017\b \001\026\002\035\024\027\024\ \r,)20( )]TJ 0.055 Tw T* (\f\r\024\007\016\013\017\b\f\016 \022)Tj /Span<>> BDC ( )Tj EMC (\021\030\036\n \253\022\017\021\026\n\273 \024\027\022\024\035\024\020\017\ \004\036\f\022\024\005 \023\024\n\024)Tj 0 Tc 0 Tw (-)Tj 0.02 Tc 0.16 Tw T* (\013\017 \f)Tj /Span<>> BDC ( )Tj EMC (\024\020\030\026\027\017\004\036\027\027\t\n \024\002\255\036\n\024\n \022\ \024\n\002\017\027\026\006\017\005. \200)Tj /Span<>> BDC ( )Tj EMC (\f\r\016)Tj 0 Tc 0 Tw (-)Tj 0.02 Tc 0.323 Tw T* (\017 \f)Tj /Span<>> BDC ( )Tj EMC [(\220\021\017\n \007\036\005\f\021\r\017\021\036\035\034\027\024 \023\036\ \030\f\024\027\017\235\017\006\017\030\024\r\026\027\027\t\036)20( )]TJ 0.089 Tw T* (\f\b\036\n\t \035\036\004\036\027\017\016, \024\f\027\024\r\026\027\027\t\ \036 \027\026)Tj /Span<>> BDC ( )Tj EMC [(\n\017\022\030\024\002\017\024\021\017\004\036\f\022\024\n)20( )]TJ 0.013 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC [(\n\031\021\026\006\017\024\027\027\024\n \f\023\036\022\021\030\036 \017\ , \027\026\023\030\017\n\036\030, \023\036\030\f\024\027\026\035\034\027\ \024\005)20( )]TJ 0.137 Tw T* (\235\026\030\n\026\022\024\022\017\027\036\021\017\022\036, \023\024\022\ \026 \004\021\024 \r\t\020\035\016\007\016\021 \235\026\027\021\026\f\021\ \017\004\036)Tj 0 Tc 0 Tw (-)Tj 0.02 Tc 0.121 Tw T* (\f\022\017\n\017, \027\024, \002\036\031\f\035\024\r\027\024, \023\036\030\ \f\023\036\022\021\017\r\027\t\n\017 \007\035\016 \002\031\007\031)Tj 0 Tc 0 Tw (-)Tj 0.02 Tc T* (\013\017\b \030\026\030\026\002\024\021\024\022.)Tj 0 Tc 0.031 Tw T* (\224 \220\021\024 \007\026\035\036\022\024 \027\036 \r\036\f\034 \f\023\036\ \022\021\030 \023\030\024\002\035\036\n, \f)Tj /Span<>> BDC ( )Tj EMC (\022\024\021\024\030\t\n\017 \n\t )Tj 0.177 Tw T* (\f\021\024\035\022\027\201\n\f\016 \r)Tj /Span<>> BDC ( )Tj EMC (\002\035\017\032\026\005\001\036\036 \r\030\036\n\016 \027\026)Tj /Span<>> BDC ( )Tj EMC (\023\031\021\017 \r\027\036\007\030\036\027\017\016 )Tj 0.045 Tw T* (\224\224 \r)Tj /Span<>> BDC ( )Tj EMC (\n\036\007\017\006\017\027\f\022\031\033 \023\030\026\022\021\017\022\031\ . \200)Tj /Span<>> BDC ( )Tj EMC (\007\026\027\027\024\005 \030\026\002\024\021\036 \n\t \027\036 )Tj 0.046 Tw T* (\f\021\026\035\017 \022\026\f\026\021\034\f\016 \023\026\030\026\n\036\007\ \017\006\017\027\f\022\017\b \026\f\023\036\022\021\024\r)Tj /Span<>> BDC ( )Tj EMC (\227 \r\024\023\030\024)Tj 0 Tw (-)Tj 0.127 Tw T* (\f\024\r \220\021\017\022\017, \027\024\030\n\026\021\017\r\027\024\020\024\ \030\036\020\031\035\017\030\024\r\026\027\017\016 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\023\030\017\027\016)Tj 0 Tw (-)Tj -0.009 Tw T* [(\021\017\017 )0.5(\030\036\001\036\027\017\005 )0.6(\n\026\001\017\027\024\005, )0.5(\026\013\017\021\t )0.5(\023\036\030\f\024\027\026\035\034\027\t\b )0.6(\007\026\027\027\t\b )]TJ -0.006 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\r \006\036\035\024\n \017\027\235\024\030\n\026\006\017\024\027\027\024\ \005 \002\036\024\023\026\f\027\024\f\021\017 \017)Tj /Span<>> BDC ( )Tj EMC (\036\013\036 \n\027\024)Tj 0 Tw (-)Tj 0.102 Tw 0 -1.218 TD [(\020\017\b )0.5(\r\024\023\030\024\f\024\r, \022\024\021\024\030\t\036, )0.5(\024\f\021\026\035\017\f\034 \026)]TJ /Span<>> BDC ( )Tj EMC 15.229 0 Td [(\030\026\n\022\026\n\017 )0.5(\007\026\027\027\024\005 )]TJ 0.084 Tw -15.229 -1.218 Td (\030\026\002\024\021\t, \027\024 \r\036\f\034\n\026 \r\036\030\024\016\021\ \027\024, \004\021\024 \017\n\036\027\027\024 \024\027\017 \r\t\005\007\031\ \021 )Tj 0.012 Tw 0 -1.218 TD (\027\026)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\r\t\005 \023\035\026\027 \017)Tj /Span<>> BDC ( )Tj EMC (\f\r\024\036\005 \f\035\024\032\027\024\f\021\034\033 \026\021\n\016\021\ \022\035\017\027\017\004\036)Tj 0 Tw (-)Tj 0 -1.218 TD (\f\022\031\033 \f\024\f\021\026\r\035\016\033\013\031\033.)Tj /T1_3 1 Tf 0.023 Tw 0 -2.436 TD (\223\030\032\255\020\034\036 \032\026\020\017\022\017\026)Tj /T1_1 1 Tf 0.399 Tw 0 -1.218 TD [(\025)-4.1(\024)-4.3(\027)1.7(\006)-6(\036)-6.8(\023)2.2(\006)-6(\017)-5.4(\016 \017)]TJ /Span<>> BDC ( )Tj EMC [(\007)-6(\017)2.7()-9.9(\026\005)1.7(\027 \017)-2.4(\f)3.1(\f)-38.9(\035)-6.8(\036)-19(\007)-4.3(\024)-4.3(\r)-8.9(\026\027)1.7(\017)-5.5(\016)13.7(:)]TJ /T1_4 1 Tf -0.007 Tc 0.406 Tw [( \223)-0.6(\013\037)-5.2(\f)-2.5(\034)2.6(\036)]TJ /Span<>> BDC 19.528 0 Td ( )Tj EMC [(\203)12.4(.\223)-9.3(.)0.8(,)-7( )]TJ -0.027 Tc 0.027 Tw -19.528 -1.218 Td [(\r)-17.2(\033)-24(\037)-18.3(\036)-10.8(\201)-23.2(\016)-24.7(\020)-16.3(\021)-17.2(\034)]TJ /Span<>> BDC 4.262 0 Td ( )Tj EMC [(\223)-29.3(.)0.5(\231.)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 0 Tc 0 Tw 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\205)10(\210\036\033 \035\030\032\204\033)30(\021)42(\032)-21(\211\033\237)]TJ 57.136 0 Td (REVIEW)Tj /T1_5 1 Tf 25 0 0 25 504.6646 56.0378 Tm (191)Tj ET endstream endobj 88 0 obj <>/Font<>/ProcSet[/PDF/Text/ImageC]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 89 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 90 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 91 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 92 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 282 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.149 Tw 10 0 0 10 70.8661 724.8299 Tm [(and selec)-16(t)-31.9(ion oper)-33(a)15(t)17(or\), \r\026\030\017\026\006\017\016 \035\017\027\036\005\027\024\005 \030\ \036\020\030\036\f)]TJ 0 Tw (-)Tj -0.003 Tw 0 -1.218 TD (\f\017\017, \f\023\036\006\017\026\035\034\027\024 \026\007\026\023\021\017\ \030\024\r\026\027\027\026\016 \007\035\016 \235\026\022\021\024\030\024\ \r, \022\024\021\024)Tj 0 Tw (-)Tj 0.059 Tw T* (\030\t\036 \007\036\n\024\027\f\021\030\017\030\031\033\021 \f\017\035\034\ \027\031\033 \n\031\035\034\021\017\022\024\035\035\017\027\036\026\030\027\ \024\f\021\034. )Tj 0 Tw T* (\231\024\004\027\024\f\021\034 \n\024\007\036\035\017 \f\024\f\021\026\r\ \017\035\026 76% [41].)Tj /T1_1 1 Tf 0.027 Tw 0 -2.436 TD (6.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (\207\033\022\003\016\020\016\020\022\016 \200\200 \036)Tj /Span<>> BDC ( )Tj EMC (\f\033\034\013\020\034\031\022\033\034\036\037\020\022\022 \f\034\024\027\ \016\034\f\016\033\037\n\022)Tj 0 Tw (-)Tj -1.296 -1.218 Td (\034\020\020\032 \034\024\027\034\t\020\016\020\022\b)Tj /T1_0 1 Tf 0.28 Tw 0 -1.218 TD (\200 \024\007\027\024\005 \017)Tj /Span<>> BDC ( )Tj EMC [(\023\036\030\r\t\b \030\026\002\024\021 $S)-16(o)-16(guer)-32(o-Ruiz \f)]TJ /Span<>> BDC ( )Tj EMC (\f\024\026\r\021.$ )Tj 0.317 Tw T* (\023\024)Tj /Span<>> BDC ( )Tj EMC 1.55 0 Td [(\023\030\024\020\027\024\017\030\024\r\026\027\017\033 )0.6(\027\036\f\024\f\021\024\016\021\036\035\034\027\024\f\021\017 )0.6(\026\027\026\f\021\024\n\024)]TJ 0 Tw (-)Tj 0.067 Tw -1.55 -1.218 Td (\026 $\203\202$ \f)Tj /Span<>> BDC ( )Tj EMC (\023\024\n\024\013\034\033 \204\210 \r)Tj /Span<>> BDC ( )Tj EMC (\022\026\004\036\f\021\r\036 \017\f\021\024\004\027\017\022\026 \007\026\ \027\027\t\b )Tj 0.335 Tw T* (\017\f\023\024\035\034\024\r\026\035\017 \026\023\017\f\017 \r)Tj /Span<>> BDC ( )Tj EMC (\220\035\036\022\021\030\024\027\027\024\005 \n\036\007\017\006\017\027\f\ \022\024\005 )Tj 0.14 Tw T* (\022\026\030\021\036. \200\030\031\004\027\031\033 \002\t\035\017 \024\021\ \024\002\030\026\027\t \023\026\006\017\036\027\021\t, \024\023\036\030\017\ \030\024)Tj 0 Tw (-)Tj 0.131 Tw 0 -1.218 TD (\r\026\027\027\t\036 \023\024)Tj /Span<>> BDC ( )Tj EMC (\023\024\r\024\007\031 \025\217\217 $402$, \f)Tj /Span<>> BDC ( )Tj EMC (\203\202 \002\t\035 31, \002\036 \031\022\026)Tj 0 Tw (-)Tj 0.293 Tw 0 -1.218 TD [(\026\027\017\016 \f\030\024\022\024\r \r\024\027\017\022\027\024\r\036\ \027\017\016 )0.5(\007\026\027\027\024\020\024 \024\f\035\024\032\027\036\027\017\016 )]TJ -0.026 Tw 0 -1.218 TD ([42]. \200)Tj /Span<>> BDC ( )Tj EMC (\022\026\004\036\f\021\r\036 \024\021\024\002\030\026\027\027\t\b \007\026\ \027\027\t\b \017\f\023\024\035\034\024\r\026\035\017\f\034: )Tj 0.133 Tw T* (\r\f\036 \f\035\024\r\026, \026\235\017\022\f\017\030\024\r\026\027\027\ \t\036 \r)Tj /Span<>> BDC ( )Tj EMC (\021\036\004\036\027\017\036 \007\r\031\b \027\036\007\036\035\034 )Tj 0.149 Tw T* (\007\024)Tj /Span<>> BDC ( )Tj EMC (\024\023\036\030\026\006\017\017 \r)Tj /Span<>> BDC ( )Tj EMC (\035\033\002\t\b \007\024\022\031\n\036\027\021\026\b, \024\021\027\024\f\ \016\013\017\b\f\016 \022\026\022 )Tj 0.113 Tw T* (\022)Tj /Span<>> BDC ( )Tj EMC (\f\021\026\006\017\024\027\026\030\027\t\n, \021\026\022 \017)Tj /Span<>> BDC ( )Tj EMC (\022 \026\n\002\031\035\026\021\024\030\027\t\n \023\024\f\036\013\036\027\ \017\016\n )Tj 0.202 Tw T* ($5409 \031\027\017\022\026\035\034\027\t\b \f\035\024\r$, \023\026\030\ \026\n\036\021\030\t \026\027\026\035\017\026 \022\030\024\r\017 )Tj 0.011 Tw T* [($\024\002\013\036\020\024 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 4.395 0 Td [(\002\017\024\b\017\n\017\004\036\f\022\024\020\024$ )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC 8.155 0 Td [(\022\035\017\027\017\004\036\f\022\017\036 )0.6(\023\024\022\026\026\021\036)]TJ 0 Tw (-)Tj 0.149 Tw -12.55 -1.218 Td (\035\017 $\004\026\f\021\024\021\026 \023\031\035\034\f\026, \021\036\n\ \023\036\030\026\021\031\030\026 \021\036\035\026, \026\030\021\036\030\017\ \026\035\034\027\024\036 )Tj -0.02 Tw T* (\007\026\r\035\036\027\017\036$. \200)Tj /Span<>> BDC ( )Tj EMC (\030\036\031\035\034\021\026\021\036 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\017\f\023\024\035\034\024\r\026\027\017\017 \r)Tj /Span<>> BDC ( )Tj EMC (\n\024\007\036\035\017 )Tj 0 Tw T* (\204\210\200 \031\007\026\035\024\f\034 \007\024\002\017\021\034\f\016 \021\ \024\004\027\024\f\021\017 92% [42].)Tj 0.033 Tw T* [(\212\026\021\f\022\024\036 \017\f\f\035\036\007\024\r\026\027\017\036 \023\ \024\007 \030\031\022\024\r\024\007\f\021\r\024\n L)-32(in V. \f)]TJ /Span<>> BDC ( )Tj EMC (\r\t)Tj 0 Tw (-)Tj 0.073 Tw T* [(\002\024\030\022\024\005 )0.5(23 )0.5(907 )0.5(\023\026\006\017\036\027\021\024\r )0.6(\002\t\035\024 )0.5(\027\026\023\030\026\r\035\036\027\024 )0.6(\027\026)]TJ /Span<>> BDC ( )Tj EMC 19.885 0 Td (\023\030\024\020)Tj /Span<>> BDC (-)Tj EMC 0.182 Tw -19.885 -1.218 Td [(\027\024\017\030\024\r\026\027\017\036 \024\f\035\024\032\027\036\027\017\ \005 )0.5(\023\024)]TJ /Span<>> BDC ( )Tj EMC [(\025\035\026\r\034\036\027-\212\017\027\007\024 )0.5(\f\021\036\023\036)]TJ 0 Tw (-)Tj 0.167 Tw T* (\027\017)Tj /Span<>> BDC ( )Tj EMC (\232)Tj /Span<>> BDC ( )Tj EMC (3B, \021\026\022\024\r\t\b \002\024\035\034\027\t\b \002\t\035\024 2958 \ $12,4%$ [43]. )Tj 0.034 Tw T* (\224)Tj /Span<>> BDC ( )Tj EMC (17190 \023\026\006\017\036\027\021\024\r, \022\024\021\024\030\t\n \235\024\ \030\n\017\030\024\r\026\035\f\016 \026\027\026\f\021\024)Tj 0 Tw (-)Tj 0.094 Tw T* (\n\024, \031)Tj /Span<>> BDC ( )Tj EMC (929 \027\026\002\035\033\007\026\035\026\f\034 \203\202)Tj /Span<>> BDC ( )Tj EMC ($5,4%$. \225\030\036\007\017 \f\030\026\r\027\017\r\026)Tj 0 Tw (-)Tj 0.102 Tw T* [(\036\n\t\b )0.5(\n\024\007\036\035\036\005 )0.6(\204\210 )0.5(\035\024\020\017\f\021\017\004\036\f\022\026\016 )0.5(\030\036\020\030\036\f\f\017\016 )0.6(\n\036\021\024\007\024\n )]TJ 0.073 Tw T* (\035\026\f\f\024 \023\024\022\026\026\035\026 \027\026\017\035\031\004\001\ \017\036 \030\036\031\035\034\021\026\021\t)Tj /Span<>> BDC ( )Tj EMC [(\227 A)17(UC 0,690. )]TJ 0.088 Tw T* (\200)Tj /Span<>> BDC ( )Tj EMC (\007\026\027\027\024\005 \030\026\002\024\021\036 \023\030\024\020\027\024\ \017\030\024\r\026\027\017\036 \023\024\f\035\036\024\023\036\030\026\006\ \017\024\027)Tj 0 Tw (-)Tj 0.09 Tw T* (\027\t\b \024\f\035\024\032\027\036\027\017\005 \002\t\035\024 \024\f\027\ \024\r\026\027\024 \021\024\035\034\022\024 \027\026)Tj /Span<>> BDC ( )Tj EMC (\023\030\036\007\024\023\036)Tj 0 Tw (-)Tj 0.091 Tw T* [(\030\026\006\017\024\027\027\t\b \235\026\022\021\024\030\026\b, )0.5(\023\024\035\031\004\036\027\027\t\b \f)]TJ /Span<>> BDC ( )Tj EMC (\017\f\023\024\035\034\024\r\026\027\017\036\n )Tj 0.192 Tw T* (\027\026\006\017\024\027\026\035\034\027\024\005 \n\036\007\017\006\017\027\ \f\022\024\005 \002\026\t \007\026\027\027\t\b. \200)Tj /Span<>> BDC ( )Tj EMC (\f\035\036\007\031)Tj 0 Tw (-)Tj 0.317 Tw T* [(\033\013\017\b \030\026\002\024\021\026\b \026\r\021\024\030\t \023\035\026\ \027\017\030\031\033\021 )0.5(\f\024\f\030\036\007\024\021\024\004\017\021\034\f\016 )]TJ 0.266 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC (\024\006\036\027\022\036 \r)Tj /Span<>> BDC ( )Tj EMC (\022\026\004\036\f\021\r\036 \023\024\021\036\027\006\017\026\035\034\027\ \t\b \023\030\036\007\017\022\021\024\030\024\r )Tj 0.056 Tw T* (\035\026\002\024\030\026\021\024\030\027\t\b \023\026\030\026\n\036\021\030\ \024\r \017)Tj /Span<>> BDC ( )Tj EMC (\035\036\022\026\030\f\021\r\036\027\027\024\020\024 \r\024\007\036\005\ )Tj 0 Tw (-)Tj T* (\f\021\r\017\016 [43].)Tj -0.002 Tc 0.175 Tw T* (\200 \017\f\f\035\036\007\024\r\026\027\017\017 Ruan \f)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. \002\t\035\026 \023\024\f\021\026\r\035\036\027\026 \026\ )Tj 0 Tc 0 Tw (-)Tj -0.002 Tc 0.298 Tw T* (\007\026\004\026 \023\024)Tj /Span<>> BDC ( )Tj EMC [(\f\024\007\026\027\017\033 \023\030\036\007\017\022\021\017\r\027\024\005\ \n\024\007\036\035\017 \030\026\r\017\021\017\016)-2( )]TJ 0.505 Tw T* (\024\f\035\024\032\027\036\027\017\005 $\017\027\235\036\022\006\017\016\ \024\023\036\030\026\006\017\024\027\027\024\005 \030\026\027\t, \017\027\ )Tj 0 Tc 0 Tw (-)Tj -0.002 Tc 0.175 Tw T* (\021\030\026\026\002\007\024\n\017\027\026\035\034\027\t\036 \026\002\f\006\ \036\f\f\t$ \027\026)Tj /Span<>> BDC ( )Tj EMC [(\024\f\027\024\r\026\027\017\017 \007\026\027\027\t\b)-2( )]TJ 0.241 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC [(\220\035\036\022\021\030\024\027\027\t\b \n\036\007\017\006\017\027\f\022\ \017\b \022\026\030\021 3535 \023\026\006\017\036\027\021\024\r)-2( )]TJ 0.051 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC [(\025\217\217 [44]. \202\r\021\024\030\t \023\024\017\006\017\024\027\017\ \030\031\033\021 \f\r\024\033 \030\026\030\026\002\024\021\022\031,)-2( )]TJ 0.043 Tw T* (\022\026\022 \n\024\007\036\035\034, \f\023\024\f\024\002\027\031\033 \030\ \026\002\024\021\026\021\034 \r)Tj /Span<>> BDC ( )Tj EMC [(\030\036\032\017\n\036 \030\036\026\035\034\027\024\020\024)-2( )]TJ -0.048 Tw T* (\r\030\036\n\036\027\017)Tj /Span<>> BDC ( )Tj EMC [(\227 \253\031 \023\024\f\021\036\035\017 \002\024\035\034\027\024\020\024\ \273. A)17.1(UC \007\026\027\027\024\005 \n\024\007\036\035\017)-2( )]TJ 0.121 Tw T* [(\020\035\031\002\024\022\024\020\024 \024\002\031\004\036\027\017\016 \007\ \035\016 \017\027\235\036\022\006\017\024\027\027\t\b \024\f\035\024\032\ \027\036\027\017\005)-2( )]TJ 0.044 Tw T* (\f\024 \f\021\024\030\024\027\t \024\023\036\030\026\006\017\024\027\027\ \024\005 \030\026\027\t \f\024\f\021\026\r\017\035\026 0,68 \017)Tj /Span<>> BDC ( )Tj EMC [(\007\035\016)-2( )]TJ -0.046 Tw T* (\r\027\031\021\030\017\024\030\020\026\027\027\t\b)Tj /Span<>> BDC ( )Tj EMC (\227 0,78, \023\030\017)Tj /Span<>> BDC ( )Tj EMC [(\220\021\024\n \026\030\b\017\021\036\022\021\031\030\026 \n\024\007\036\ \035\017)-2( )]TJ 0.128 Tw T* (\027\036 \023\024\r\024\035\016\036\021 \r\t\007\036\035\017\021\034 \235\ \026\022\021\024\030\t, \024\022\026\t\r\026\033\013\017\036 \027\026\017\ )Tj 0 Tc 0 Tw (-)Tj -0.002 Tc T* (\002\024\035\034\001\036\036 \r\035\017\016\027\017\036 \027\026)Tj /Span<>> BDC ( )Tj EMC (\030\036\031\035\034\021\026\021 \023\030\036\007\f\022\026\026\027\017\ \016 [44].)Tj 0 Tc 0.295 Tw T* (\225\017\027\007\030\024\n \027\017\022\024\005 \023\036\030\036\007\027\ \036\005 \030\036\036\022\006\017\017 $\225\203\215\217$ \016\r\035\016\ )Tj 0 Tw (-)Tj 0.292 Tw T* [(\036\021\f\016 \030\026\f\023\030\024\f\021\030\026\027\036\027\027\t\n \ )0.5(\024\f\035\024\032\027\036\027\017\036\n \031)]TJ /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r )Tj 0.232 Tw 23.244 64.543 Td (\f)Tj /Span<>> BDC ( )Tj EMC 0.901 0 Td [(\022\024\035\024\030\036\022\021\026\035\034\027\t\n )0.6(\030\026\022\024\n, )0.5(\022\024\021\024\030\024\036 )0.5(\f\036\030\034\036\027\024 )0.6(\r\035\017\016\036\021 )]TJ 0.207 Tw -0.901 -1.218 Td (\027\026)Tj /Span<>> BDC ( )Tj EMC (\022\026\004\036\f\021\r\024 \032\017\027\017 \r)Tj /Span<>> BDC ( )Tj EMC (\023\024\f\035\036\024\023\036\030\026\006\017\024\027\027\024\n \023\036\ \030\017\024\007\036. )Tj 0.096 Tw T* (\200)Tj /Span<>> BDC ( )Tj EMC (\027\026\f\021\024\016\013\036\036 \r\030\036\n\016 \220\021\017\024\035\ \024\020\017\016 \225\203\215\217 \r\f\036 \036\013\036 \027\036\016\f\027\ \026, )Tj 0.161 Tw T* (\027\024 \007\024\f\021\024\r\036\030\027\024 \024\023\030\036\007\036\035\ \036\027\t \027\036\022\024\021\024\030\t\036 \235\026\022\021\024\030\t\ \030\017)Tj 0 Tw (-)Tj 0.041 Tw T* (\f\022\026 [45]. \200)Tj /Span<>> BDC ( )Tj EMC (\017\f\f\035\036\007\024\r\026\027\017\036 Huang \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. \002\t\035\024 \r\022\035\033)Tj 0 Tw (-)Tj 0.232 Tw T* (\004\036\027\024 342 \023\026\006\017\036\027\021\026, \004\026\f\021\024\ \021\026 \225\203\215\217 \f\024\f\021\026\r\017\035\026 47,4% )Tj 0.223 Tw 0 -1.218 TD ($162/342$, \023\036\030\017\024\007 \027\026\002\035\033\007\036\027\017\ \016)Tj /Span<>> BDC ( )Tj EMC (\227 6 \n\036\f\016\006\036\r [46]. )Tj 0.055 Tw 0 -1.218 TD [(\202\r\021\024\030\026\n\017 )0.5(\002\t\035\017 )0.6(\017\f\023\024\035\034\024\r\026\027\t )0.5(\023\016\021\034 )0.6(\026\035\020\024\030\017\021\n\024\r )0.5(\022\035\026\f)]TJ 0 Tw (-)Tj -0.036 Tw T* (\f\017\235\017\022\026\006\017\017 \204\210)Tj /Span<>> BDC ( )Tj EMC (\227 KH, \026\035\020\024\030\017\021\n \024\023\024\030\027\t\b \r\036\022\ \021\024\030\024\r, \212\217, )Tj 0.145 Tw T* (\225\214 \017)Tj /Span<>> BDC ( )Tj EMC (\026\035\020\024\030\017\021\n\t \017\f\022\031\f\f\021\r\036\027\027\024\ \005 \027\036\005\030\024\027\027\024\005 \f\036\021\017 \007\035\016 )Tj 0.093 Tw T* (\n\024\007\036\035\017\030\024\r\026\027\017\016 \007\026\027\027\t\b. \217\ \036\031\035\034\021\026\021\t \023\024\022\026\026\035\017 \031 \r\f\036\ \b )Tj 0.088 Tw T* [(\b\024\030\024\001\031\033 \007\017\026\020\027\024\f\021\017\004\036\f\022\ \031\033 )0.5(\220\235\235\036\022\021\017\r\027\024\f\021\034, \023\030\017)]TJ /Span<>> BDC ( )Tj EMC (\220\021\024\n )Tj 0 Tw 0 -1.218 TD (\n\024\007\036\035\017 \212\217 \017)Tj /Span<>> BDC ( )Tj EMC [(\225\214 \017\n\036\035\017 A)17.2(UC \r\t\001\036 0,85 [46].)]TJ 0.018 Tc 0.149 Tw 0 -1.218 TD [(\200 \007\030\031\020\024\n \017\f\f\035\036\007\024\r\026\027\017\017 \022\ \024\035\035\036\022\021\017\r\024\n \026\r\021\024\030\024\n \023\024\007\ )18( )]TJ 0.169 Tw 0 -1.218 TD [(\030\031\022\024\r\024\007\f\021\r\024\n Chen \002\t\035\026 \030\026\030\ \026\002\024\021\026\027\026 \n\024\007\036\035\034 \204\210,)18( )]TJ 0.658 Tw T* [(\023\030\036\007\f\022\026\t\r\026\033\013\026\016 )0.5(\r\036\030\024\016\021\027\024\f\021\034 )0.5(\023\024\r\021\024\030\027\024\005 )0.6(\020\024\f)]TJ 0 Tc 0 Tw (-)Tj 0.018 Tc 0.336 Tw T* (\023\017\021\026\035\017\026\006\017\017 \r)Tj /Span<>> BDC ( )Tj EMC [(\021\036\004\036\027\017\036 30 \007\027\036\005 \023\024\f\035\036 \r\t\ \023\017\f\022\017)18( )]TJ 0.312 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\f\021\026\006\017\024\027\026\030\026 [47]. \203\026\002\024\030 \007\026\ \027\027\t\b \023\030\024\017\r\024\007\017\035)Tj 0 Tc 0 Tw (-)Tj 0.018 Tc 0.108 Tw T* (\f\016 \031)Tj /Span<>> BDC ( )Tj EMC (213827)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r, \017)Tj /Span<>> BDC ( )Tj EMC (\022\024\021\024\030\t\b 23083)Tj /Span<>> BDC ( )Tj EMC [($10,8%$)18( )]TJ 0.277 Tw T* (\002\t\035\017 \020\024\f\023\017\021\026\035\017\017\030\024\r\026\027\ \t \023\024\r\021\024\030\027\024. \215\030\017)Tj /Span<>> BDC ( )Tj EMC (\017\f\023\024\035\034)Tj 0 Tc 0 Tw (-)Tj 0.018 Tc 0.351 Tw T* (\024\r\026\027\017\017 \n\024\007\036\035\017 \017\f\022\031\f\f\021\r\036\ \027\027\024\005 \027\036\005\030\024\f\036\021\017 \026\r\021\024)Tj 0 Tc 0 Tw (-)Tj 0.018 Tc 0.128 Tw T* [(\030\t \023\024\035\031\004\017\035\017 \023\024\035\031\004\017\035 A)17(UC, \030\026\r\027\031\033 0,751 $95% \212\224)18( )]TJ 0 Tw T* (0,743\2260,759$ [47].)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 303.3769 420.3798 Tm [(\037\036)10(\032\223\212\226\034\022\031\034)]TJ 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0 Tc 0.11 Tw 10 0 0 10 303.3071 396.0238 Tm (\200 \007\026\027\027\024\005 \030\026\002\024\021\036 \n\t \f\021\026\r\ \017\035\017 \f\r\024\036\005 \026\007\026\004\036\005 \017\031\004\017\ \021\034 )Tj 0.146 Tw T* (\024\f\027\024\r\027\t\036 \027\026\023\030\026\r\035\036\027\017\016 \030\ \026\030\026\002\024\021\024\022 \r)Tj /Span<>> BDC ( )Tj EMC (\f\235\036\030\036 \224\224, \017\f)Tj 0 Tw (-)Tj 0.119 Tw T* (\023\024\035\034\031\036\n\t\036 \007\035\016 \r\036\007\036\027\017\016\ \023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\025\217\217. \207\024\035\034\001\024\036 )Tj 0.362 Tw T* [(\022\024\035\017\004\036\f\021\r\024 \021\026\022\017\b \017\f\f\035\036\ \007\024\r\026\027\017\005 )0.5(\016\r\035\016\036\021\f\016 \024\021\030\026\032\036)]TJ 0 Tw (-)Tj 0.128 Tw T* (\027\017\036\n \027\026\f\021\024\016\013\036\020\024 \021\030\036\027\007\ \026 \017\f\023\024\035\034\024\r\026\027\017\016 \224\224 \r\024 \r\f\036\ \b )Tj 0.256 Tw T* (\f\235\036\030\026\b, \r)Tj /Span<>> BDC ( )Tj EMC (\021\024\n \004\017\f\035\036 \017)Tj /Span<>> BDC ( )Tj EMC (\n\036\007\017\006\017\027\036 [25,31,35\22637,44]. )Tj 0.103 Tw T* (\210\021\004\036\021\035\017\r\024 \r\017\007\027\024, \004\021\024 \n\024\ \007\036\035\017 \017\f\022\031\f\f\021\r\036\027\027\024\020\024 \017\027\ \021\036\035)Tj 0 Tw (-)Tj 0.159 Tw T* (\035\036\022\021\026 \n\024\020\031\021 \023\030\017\n\036\027\016\021\034\ \f\016 \007\035\016 \023\030\017\027\016\021\017\016 \030\036\001\036\027\ \017\005 \024\002 )Tj 0.098 Tw T* (\024\023\036\030\026\006\017\017, \r\t\016\r\035\036\027\017\016 \017)Tj /Span<>> BDC ( )Tj EMC (\f\n\016\020\004\036\027\017\016 \n\024\007\017\235\017\006\017\030\031\036\ \n\t\b )Tj 0.064 Tw T* (\235\026\022\021\024\030\024\r \030\017\f\022\026, \023\030\024\020\027\024\ \017\030\024\r\026\027\017\016 \017)Tj /Span<>> BDC ( )Tj EMC (\r\036\007\036\027\017\016 \024\f\035\024\032)Tj 0 Tw (-)Tj -0.004 Tw T* (\027\036\027\017\005 [11,12,41,47]. \215\030\017)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\n \024\002\030\026\013\026\033\021 \027\026)Tj /Span<>> BDC ( )Tj EMC (\f\036\002\016 \r\027\017)Tj 0 Tw (-)Tj 0.045 Tw T* (\n\026\027\017\036 \030\016\007 \024\f\024\002\036\027\027\024\f\021\036\ \005, \023\030\017\f\031\013\017\b \n\027\024\020\017\n \023\031\002\035\ \017\022\026)Tj 0 Tw (-)Tj T* (\006\017\016\n \023\024)Tj /Span<>> BDC ( )Tj EMC (\007\026\027\027\024\005 \021\036\n\026\021\017\022\036.)Tj 0.297 Tw T* (\200\024-\023\036\030\r\t\b, \f\031\007\016 \023\024)Tj /Span<>> BDC ( )Tj EMC (\026\r\021\024\030\f\022\017\n \022\024\035\035\036\022\021\017\r\026\n,\ \021\026\022\017\036 )Tj 0.239 Tw T* (\030\026\002\024\021\t \016\r\035\016\033\021\f\016 \023\030\036\030\024\ \020\026\021\017\r\024\005 \022\030\031\023\027\t\b \031\027\017\r\036\030\ \f\017)Tj 0 Tw (-)Tj 0.044 Tw T* [(\021\036\021\f\022\017\b )0.6(\006\036\027\021\030\024\r, )0.5(\020\007\036 )0.5(\r\024\n\024\032\027\t )0.5(\022\024\035\035\026\002\024\030\026\006\017\017 )0.6(\n\036\032\007\031 )]TJ -0.002 Tw T* [(\020\030\031\023\023\026\n\017 )0.6(\n\026\021\036\n\026\021\017\022\024\r-\023\030\024\020\030\026\n\n\017\f\ \021\024\r )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC 16.969 0 Td (\022\035\017\027\017\006\017\f\021\026)Tj 0 Tw (-)Tj 0.014 Tw -16.969 -1.218 Td (\n\017 [17,25,30,34]. \215\030\017\004\036\n \r)Tj /Span<>> BDC ( )Tj EMC (\027\036\022\024\021\024\030\t\b \017\f\f\035\036\007\024\r\026\027\017\016\ \b )Tj 0.099 Tw T* (\024\021\004\036\021\035\017\r\024 \r\017\007\027\024, \004\021\024 \027\ \024\f\017\021\036\035\016\n\017 \023\024\r\036\f\021\022\017 \r\t\f\021\ \031\023\026)Tj 0 Tw (-)Tj 0.019 Tw T* (\033\021 \017\n\036\027\027\024 \n\026\021\036\n\026\021\017\004\036\f\022\ \017\036 \022\024\035\035\036\022\021\017\r\t. \231\026\022\024\005 \r\t\ \r\024\007 )Tj -0.013 Tw T* (\n\t \007\036\035\026\036\n \023\024)Tj /Span<>> BDC ( )Tj EMC (\024\004\036\r\017\007\027\t\n, \f)Tj /Span<>> BDC ( )Tj EMC (\021\024\004\022\017 \030\036\027\017\016 \022\035\017\027\017\006\017\f\ \021\026, )Tj 0.045 Tw T* (\023\024\020\030\036\001\027\024\f\021\016\n \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\r\t\002\024\030\036 \022\035\033\004\036\r\t\b \235\026\022\021\024\030\ \024\r $\023\030\024)Tj 0 Tw (-)Tj -0.001 Tw T* (\020\027\024\017\030\024\r\026\027\017\036 \n\036\f\021\027\024\020\024\ \030\036\006\017\007\017\r\026 \002\036 \031\004\036\021\026 R-\f\021\026\ \021\031\f\026 )Tj -0.053 Tw T* (\024\023\031\b\024\035\017, \024\023\030\036\007\036\035\036\027\017\036\ \n\031\021\026\006\017\024\027\027\024\020\024 \023\030\024\235\017\035\ \016 \f)Tj /Span<>> BDC ( )Tj EMC (\023\024\n\024)Tj 0 Tw (-)Tj 0.072 Tw T* (\013\034\033 \030\026\007\017\024\n\027\024\005 \n\024\007\036\035\017 \204\ \217\231)Tj /Span<>> BDC ( )Tj EMC [(\227 \017\024\002\030\026\032\036\027\017\005 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC (\021.\007.$ )Tj 0.019 Tw T* ([33,36,41,42]. \231\026\022, \r)Tj /Span<>> BDC ( )Tj EMC [(\017\f\f\035\036\007\024\r\026\027\017\017 S)-16(o)-16(guer)-32(o-Ruiz \f)]TJ /Span<>> BDC ( )Tj EMC (\f\024)Tj 0 Tw (-)Tj -0.064 Tw T* (\026\r\021., \020\007\036 \f)Tj /Span<>> BDC ( )Tj EMC (\006\036\035\034\033 \023\030\024\020\027\024\026 \b\017\030\031\030\020\ \017\004\036\f\022\017\b \024\f\035\024\032\027\036\027\017\005 )Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0 Tw 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\205)10(\210\036\033 \035\030\032\204\033)30(\021)42(\032)-21(\211\033\237)]TJ 57.136 0 Td (REVIEW)Tj -57.136 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 23, \023\0222, 202)69(4)]TJ 42.99 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 23, \023\0222, 202)69(4)]TJ /T1_4 1 Tf 25 0 0 25 20.7776 56.0378 Tm (190)Tj ET endstream endobj 280 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\240\025)21(\220\024\025\226\004\025\r)-9.9(\026\005 \005\022\225\t\235\r\225\t\017)-9.9(\026\005\f\007 \225\235\005\024\t\004\t\004\005\200 \005\r\017\002\r\r)-10(\026\f\t\004\004\025\006)10(\025 )]TJ 0 -1 TD [(\005\004\026)11(\t\b\b\t\017)-9.9(\026)11(\016 \f\022\b\t\020\t\004\005\005 \017)10(\025\b\025\235\t\017)-9.9(\026)10.9(\016\b\206\004\025\006)10(\025 \235\016\017\016 $\025\213\220\025\235\022\b\005\026)11(\t\235\016\026)-20(\002\235\007$)]TJ 40.064 1 Td [(P)10(ossibilities and pr)20(ospects of ar)-20(tif)-20.9(icial intelligence in )]TJ 3.722 -1 Td [(th)11(e tr)31(eatment of color)31.1(ectal cancer $r)31(e)11(vie)11(w$)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0.198 Tw 10 0 0 10 42.5197 359.4899 Tm (\026\002\024\035\036\r\026\027\017\016 \f\036\030\007\006\026, \b\017\030\ \031\030\020\017\004\036\f\022\024\036 \r\n\036\001\026\021\036\035\034\f\ \021\r\024, )Tj -0.005 Tw 0 -1.218 TD (\023\024\032\017\035\024\005 \r\024\030\026\f\021. \025 \f\024\032\026\035\ \036\027\017\033, \r)Tj /Span<>> BDC ( )Tj EMC (\007\026\027\027\024\n \017\f\f\035\036\007\024\r\026)Tj 0 Tw (-)Tj T* (\027\017\017 \027\036\021 \017\027\235\024\030\n\026\006\017\017 \024)Tj /Span<>> BDC ( )Tj EMC (\r\027\036\001\027\036\005 \r\026\035\017\007\026\006\017\017)Tj /Span<>> BDC ( )Tj EMC ([11].)Tj 0.035 Tw T* [(\200 )0.5(\007\030\031\020\024\n )0.5(\017\f\f\035\036\007\024\r\026\027\017\017 )0.6($Oy)22(a)-17(ga-Ir)-36.9(iar)-22(te )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 16.865 0 Td [(\f\024\026\r\021.$ )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC 3.892 0 Td (\023\024)Tj 0 Tw (-)Tj 0.071 Tw -20.757 -1.218 Td (\n\024\013\034\033 \212\217, \225\214 \017)Tj /Span<>> BDC ( )Tj EMC (\204\210\200 \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\n\036\021\026\f\021\026\021\017\004\036\f\022\017\n )Tj 0.177 Tw T* [(\025\217\217 \023\030\036\007\f\022\026\t\r\026\035\026\f\034 \021\024\022\ \f\017\004\027\024\f\021\034 )0.5(\017\030\017\027\024\021\036\022\026\027\026 )0.5(\007\035\016 )]TJ 0.094 Tw T* (\022\026\032\007\024\020\024 \006\017\022\035\026 \035\036\004\036\027\017\ \016. \215\030\017\004\036\n \021\024\004\027\024\f\021\034 \023\030\024\ \020\027\024\017)Tj 0 Tw (-)Tj -0.001 Tw T* (\030\024\r\026\027\017\016 \035\036\005\022\024\023\036\027\017\017 \002\ \t\035\026 75%, \027\036\005\021\030\024\023\036\027\017\017)Tj /Span<>> BDC ( )Tj EMC (\227 88%, )Tj 0.21 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\007\017\026\030\036\017)Tj /Span<>> BDC ( )Tj EMC [(\227 95%. )0.5(\210\020\030\026\027\017\004\036\027\017\036\n )0.5(\022\035\017\027\017\004\036\f\022\024\020\024 )0.5(\017\f)]TJ 0 Tw (-)Tj 0.08 Tw T* (\023\024\035\034\024\r\026\027\017\016 \n\024\007\036\035\017 \016\r\035\ \016\036\021\f\016 \027\036 \f\021\024\035\034\022\024 \024\021\f\031\021\ \f\021\r\017\036 )Tj 0.092 Tw T* (\r\027\036\001\027\036\005 \r\026\035\017\007\026\006\017\017, \f\022\024\ \035\034\022\024 \017\f\023\024\035\034\024\r\026\027\017\036 \r\024 \r\ \b\024)Tj 0 Tw (-)Tj 0.087 Tw T* (\007\016\013\017\b \007\026\027\027\t\b \023\026\030\026\n\036\021\030\024\ \r \235\026\030\n\026\022\024\022\017\027\036\021\017\022\017 \017\030\017\ \027\024)Tj 0 Tw (-)Tj 0.118 Tw T* (\021\036\022\026\027\026, \004\021\024 \027\036 \016\r\035\016\036\021\f\ \016 \030\031\021\017\027\027\t\n \022\035\017\027\017\004\036\f\022\017\ \n \021\036\f)Tj /Span<>> BDC (-)Tj EMC 0 Tw T* (\021\024\n [12].)Tj /T1_2 1 Tf 0 -2.436 TD (5.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (\200\200 \036)Tj /Span<>> BDC ( )Tj EMC (\022\033\023\033\013\022\201\016\024\021\022 \024\035\033\037\035\016\013\ \022\030 \027\016\201\016\020\022\030 \r\210\210)Tj /T1_1 1 Tf 0.221 Tw -1.296 -1.218 Td [(\230\027\007\024\f\022\024\023\017\004\036\f\022\026\016 \030\036\036\022\ \006\017\016 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC [(\023\024\007\f\035\017\017\f\021\026\016 )0.5(\007\017\f\f\036\022)]TJ 0 Tw (-)Tj 0.025 Tw 0 -1.218 TD (\006\017\016 \016\r\035\016\033\021\f\016 \220\235\235\036\022\021\017\r\ \027\t\n\017 \n\036\021\024\007\026\n\017 \035\036\004\036\027\017\016 \030\ \026\027)Tj 0 Tw (-)Tj 0.137 Tw T* (\027\017\b \f\021\026\007\017\005 \025\217\217 [38], \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\017 \r\t\002\024\030\036 \n\036\021\024\007\026 \035\036\004\036\ \027\017\016 )Tj 0.03 Tw T* (\024\f\027\024\r\027\024\005 \023\030\024\002\035\036\n\024\005 \016\r\035\ \016\036\021\f\016 \024\006\036\027\022\026 N-\f\021\026\021\031\f\026 \024\ \023\031)Tj 0 Tw (-)Tj 0.013 Tw T* (\b\024\035\017. \200)Tj /Span<>> BDC ( )Tj EMC (\017\f\f\035\036\007\024\r\026\027\017\017 \023\024\007 \030\031\022\024\ \r\024\007\f\021\r\024\n Jin J., \023\024\f\035\036 )Tj 0.099 Tw T* (\024\002\030\026\002\024\021\022\017 \007\026\027\027\t\b 1194 \023\026\006\ \017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\025\217\217 $pT1NxM0$ )Tj 0.472 Tw T* (\023\024\f\035\036 \220\027\007\024\f\022\024\023\017\004\036\f\022\024\020\ \024 \035\036\004\036\027\017\016 \002\t\035\024 \024\021\024\002\030\026\ \027\024 )Tj 0.414 Tw T* (10)Tj /Span<>> BDC ( )Tj EMC [(\023\026\021\024\n\024\030\235\024\035\024\020\017\004\036\f\022\017\b )0.5(\023\026\030\026\n\036\021\030\024\r \017)]TJ /Span<>> BDC ( )Tj EMC 18.17 0 Td (\n\026\030\022\036\030\024\r )Tj 0.062 Tw 5.074 28.009 Td (\r\024\f\023\026\035\036\027\017\016 [39]. \203\026)Tj /Span<>> BDC ( )Tj EMC (\024\f\027\024\r\026\027\017\017 \220\021\017\b \007\026\027\027\t\b \f)Tj /Span<>> BDC ( )Tj EMC (\023\024\n\024)Tj 0 Tw (-)Tj 0.034 Tw T* (\013\034\033 \n\036\021\024\007\026 \225\214 \002\t\035\026 \f\024\007\026\ \027\026 \n\024\007\036\035\034 \204\210 \f)Tj /Span<>> BDC ( )Tj EMC (\021\024\004\027\024\f\021\034\033 )Tj 0.059 Tw T* (\023\030\024\020\027\024\017\030\024\r\026\027\017\016 \023\024\030\026\ \032\036\027\017\016 \214\211 \007\024)Tj /Span<>> BDC ( )Tj EMC (85% [39]. \200)Tj /Span<>> BDC ( )Tj EMC (\007\030\031)Tj 0 Tw (-)Tj -0.058 Tw T* (\020\024\n \017\f\f\035\036\007\024\r\026\027\017\017, \023\030\024\r\036\ \007\036\027\027\024\n Ichimasa \f)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021., \017\f)Tj 0 Tw (-)Tj 0.085 Tw T* (\023\024\035\034\024\r\026\035\017\f\034 \007\026\027\027\t\036 511 \023\ \026\006\017\036\027\021\024\r \025\217\217 $pT2NxM0$ )Tj 0.109 Tw T* ([40]. \224\f\f\035\036\007\024\r\026\021\036\035\017 \021\036\f\021\017\030\ \024\r\026\035\017 \020\017\023\024\021\036\031 \017\002\t\021\024\004\ )Tj 0 Tw (-)Tj 0.023 Tw T* [(\027\024\f\021\017 \023\024\035\027\024\006\036\027\027\024\005 \030\036\ \036\022\006\017\017 )0.5(\023\030\016\n\024\005 )0.5(\022\017\001\022\017 \023\030\017)]TJ /Span<>> BDC ( )Tj EMC (\030\2312, )Tj 0.031 Tw T* (\021\026\022 \022\026\022 \023\024\030\026\032\036\027\017\036 \214\211 \ \027\026\002\035\033\007\026\036\021\f\016 \023\030\017\n\036\030\027\024\ \021\024\035\034\022\024 )Tj 0.191 Tw T* (\031)Tj /Span<>> BDC ( )Tj EMC (25% \023\026\006\017\036\027\021\024\r \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\007\026\027\027\024\005 \f\021\026\007\017\017. \200)Tj /Span<>> BDC ( )Tj EMC (\030\036\031\035\034\021\026\021\036 )Tj 0.126 Tw T* (\023\036\030\r\017\004\027\024\020\024 \026\027\026\035\017\026 \002\t\035\ \024 \024\021\024\002\030\026\027\024 8 \022\035\017\027\017\022\024-\n\024\ \030)Tj 0 Tw (-)Tj 0.201 Tw T* (\235\024\035\024\020\017\004\036\f\022\017\b \023\024\022\026\026\021\036\ \035\036\005. \215\030\017)Tj /Span<>> BDC ( )Tj EMC (\023\024\n\024\013\017 \026\035\020\024\030\017\021\n\026 )Tj 0.21 Tw T* (\225\214 \002\t\035\026 \f\024\007\026\027\026 \n\024\007\036\035\034 \f\ )Tj /Span<>> BDC ( )Tj EMC (\004\031\r\f\021\r\017\021\036\035\034\027\024\f\021\034\033 96% )Tj 0.326 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\f\023\036\006\017\235\017\004\027\024\f\021\034\033 88%. \224\f\b\024\007\ \016 \017)Tj /Span<>> BDC ( )Tj EMC (\007\026\027\027\t\b \220\021\024\020\024 )Tj 0.3 Tw T* [(\017\f\f\035\036\007\024\r\026\027\017\016, )0.6(64% )0.5(\023\026\006\017\036\027\021\024\r )0.6(\n\024\020\035\017 )0.5(\002\t )0.5(\017\002\036\032\026\021\034 )]TJ 0.08 Tw T* (\024\023\036\030\026\006\017\017, \r)Tj /Span<>> BDC ( )Tj EMC (\021\024 \r\030\036\n\016 \022\026\022 1,6% \023\026\006\017\036\027\021\ \024\r \f)Tj /Span<>> BDC ( )Tj EMC (\n\036\021\026\f\021\026)Tj 0 Tw (-)Tj 0.095 Tw T* (\026\n\017 \r)Tj /Span<>> BDC ( )Tj EMC (\214\211 \023\024\021\036\030\016\035\017 \002\t \001\026\027\f \027\026\ )Tj /Span<>> BDC ( )Tj EMC (\b\017\030\031\030\020\017\004\036\f\022\024\036 \r\n\036)Tj 0 Tw (-)Tj -0.02 Tw T* [(\001\026\021\036\035\034\f\021\r\024 )0.6([40]. )0.5(\200)]TJ /Span<>> BDC ( )Tj EMC 7.905 0 Td [(\017\f\f\035\036\007\024\r\026\027\017\017 )0.5(\022\024\035\035\036\022\021\017\r\026 )0.5(\026\r\021\024\030\024\r )]TJ 0.169 Tw -7.905 -1.218 Td (\017)Tj /Span<>> BDC ( )Tj EMC [(\222\032\027\024\005 \025\024\030\036\017 \023\024\007 \030\031\022\024\r\ \024\007\f\021\r\024\n K)-16(ang J. \027\026)]TJ /Span<>> BDC ( )Tj EMC (\r\t)Tj 0 Tw (-)Tj -0.027 Tw T* (\002\024\030\022\036 \017)Tj /Span<>> BDC ( )Tj EMC (316 \023\026\006\017\036\027\021\024\r \002\t\035\024 \024\021\024\002\030\ \026\027\024 9 \023\026\030\026\n\036\021\030\024\r, )Tj 0.215 Tw T* (\024\007\027\017\n \017)Tj /Span<>> BDC ( )Tj EMC (\022\024\021\024\030\t\b \016\r\035\016\035\026\f\034 \f\021\036\023\036\ \027\034 \017\027\235\017\035\034\021\030\026\006\017\017 )Tj 0.402 Tw T* (\024\023\031\b\024\035\017 \035\017\n\235\024\006\017\021\026\n\017 [41]\ . \224\f\b\024\007\016 \017)Tj /Span<>> BDC ( )Tj EMC (\n\036\021\024\007\017\022\017 )Tj 0.42 Tw T* ($\024\006\036\027\022\026 \022\024\220\235\235\017\006\017\036\027\021\024\ \r \035\017\027\036\005\027\024\005 \030\036\020\030\036\f\f\017\024\027\ \027\024\005 )Tj 0.108 Tw T* (\n\024\007\036\035\017$ \007\035\016 \f\024\007\026\027\017\016 \n\024\ \007\036\035\017, \017\f\023\024\035\034\024\r\026\035\f\016 \n\036\021\ \024\007 )Tj 0.173 Tw T* (\030\036\020\030\036\f\f\017\017 \035\026\f\f\024)Tj /Span<>> BDC ( )Tj EMC [(\227 L)-34.9(A)35(S)17(SO \(least absol)35(ute shr)-37(ink)-16.9(a)-17(ge )]TJ 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0.023 Tw 9 0 0 9 42.5197 730.483 Tm (\020\004\206\f\t\204\004 1.)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf ( \207\016\033\024\f\016\021\035\022\036\020\032\016 \003\034\004\016\027\ \022 \003\037\235\022\020\020\034\013\034 \034\025\023\201\016\020\022\030\ \004\027\030 \f\033\034\013\020\034\031\022\033\034\036\037\020\022\030\ \022\024\034\004\037 \f\033\022)Tj /Span<>> BDC ( )Tj EMC (\033\037\031\027\022\201\020\032 \036\037\033\022\037\020\035\037 \036\ \032\025\033\037\020)Tj 0 Tw (-)Tj 0 -1.2 TD (\020\034\b \035\016\033\037\f\016\036\035\022\201\016\024\021\034\b \024\ \035\033\037\035\016\013\022\022)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf T* [(T)48(able 1)47(.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf [( Promising machine lear)-13.7(ning models for p)46.1(redicting the outcome of v)16(ar)-36.9(ious v)16(ar)-36.9(iants of the treatment strategy)]TJ ET 0 0 0 1 K 0.5 w /GS2 gs q 1 0 0 1 42.5197 704.381 cm 0 0 m 42.77 0 l S Q q 1 0 0 1 42.7697 683.5618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 85.2894 704.381 cm 0 0 m 121.89 0 l S Q q 1 0 0 1 85.2894 683.5618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 207.1791 704.381 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 207.1791 683.5618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 320.565 704.381 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 320.565 683.5618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 411.2736 704.381 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 411.2736 683.5618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 496.313 683.5618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 42.5197 683.3118 cm 0 0 m 42.77 0 l S Q q 1 0 0 1 42.7697 652.9005 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 85.2894 683.3118 cm 0 0 m 121.89 0 l S Q q 1 0 0 1 85.2894 652.9005 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 207.1791 683.3118 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 207.1791 652.9005 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 320.565 683.3118 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 320.565 652.9005 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 411.2736 683.3118 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 411.2736 652.9005 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 496.313 652.9005 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 42.5197 652.6505 cm 0 0 m 42.77 0 l S Q q 1 0 0 1 42.7697 612.6393 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 85.2894 652.6505 cm 0 0 m 121.89 0 l S Q q 1 0 0 1 85.2894 612.6393 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 207.1791 652.6505 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 207.1791 612.6393 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 320.565 652.6505 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 320.565 612.6393 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 411.2736 652.6505 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 411.2736 612.6393 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 496.313 612.6393 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 42.5197 612.3893 cm 0 0 m 42.77 0 l S Q q 1 0 0 1 42.7697 562.778 cm 0 0 m 0 49.361 l S Q q 1 0 0 1 85.2894 612.3893 cm 0 0 m 121.89 0 l S Q q 1 0 0 1 85.2894 562.778 cm 0 0 m 0 49.361 l S Q q 1 0 0 1 207.1791 612.3893 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 207.1791 562.778 cm 0 0 m 0 49.361 l S Q q 1 0 0 1 320.565 612.3893 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 320.565 562.778 cm 0 0 m 0 49.361 l S Q q 1 0 0 1 411.2736 612.3893 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 411.2736 562.778 cm 0 0 m 0 49.361 l S Q q 1 0 0 1 496.313 562.778 cm 0 0 m 0 49.361 l S Q q 1 0 0 1 42.5197 562.528 cm 0 0 m 42.77 0 l S Q q 1 0 0 1 42.7697 503.3167 cm 0 0 m 0 58.961 l S Q q 1 0 0 1 85.2894 562.528 cm 0 0 m 121.89 0 l S Q q 1 0 0 1 85.2894 503.3167 cm 0 0 m 0 58.961 l S Q q 1 0 0 1 207.1791 562.528 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 207.1791 503.3167 cm 0 0 m 0 58.961 l S Q q 1 0 0 1 320.565 562.528 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 320.565 503.3167 cm 0 0 m 0 58.961 l S Q q 1 0 0 1 411.2736 562.528 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 411.2736 503.3167 cm 0 0 m 0 58.961 l S Q q 1 0 0 1 496.313 503.3167 cm 0 0 m 0 58.961 l S Q q 1 0 0 1 42.5197 503.0667 cm 0 0 m 42.77 0 l S Q q 1 0 0 1 42.7697 463.0554 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 85.2894 503.0667 cm 0 0 m 121.89 0 l S Q q 1 0 0 1 85.2894 463.0554 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 207.1791 503.0667 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 207.1791 463.0554 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 320.565 503.0667 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 320.565 463.0554 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 411.2736 503.0667 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 411.2736 463.0554 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 496.313 463.0554 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 42.5197 462.8054 cm 0 0 m 42.77 0 l S Q q 1 0 0 1 42.7697 422.7941 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 85.2894 462.8054 cm 0 0 m 121.89 0 l S Q q 1 0 0 1 85.2894 422.7941 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 207.1791 462.8054 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 207.1791 422.7941 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 320.565 462.8054 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 320.565 422.7941 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 411.2736 462.8054 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 411.2736 422.7941 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 496.313 422.7941 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 42.5197 422.5441 cm 0 0 m 42.77 0 l S Q q 1 0 0 1 42.7697 382.5328 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 85.2894 422.5441 cm 0 0 m 121.89 0 l S Q q 1 0 0 1 85.2894 382.5328 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 207.1791 422.5441 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 207.1791 382.5328 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 320.565 422.5441 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 320.565 382.5328 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 411.2736 422.5441 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 411.2736 382.5328 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 496.313 382.5328 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 42.5197 382.2828 cm 0 0 m 42.77 0 l S Q q 1 0 0 1 85.2894 382.2828 cm 0 0 m 121.89 0 l S Q q 1 0 0 1 207.1791 382.2828 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 320.565 382.2828 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 411.2736 382.2828 cm 0 0 m 85.289 0 l S Q BT /GS1 gs /T1_3 1 Tf 8 0 0 8 53.7856 690.9465 Tm (\032\003\002\006)Tj 7.236 0 Td (\025\004\213\b\004\201\r\b\t\r \214\002\240\r\f\t)Tj 13.674 0.6 Td (\231\004\006\004\220\003\r\006\t\217\003\t\220\004 \240\004\b\b\013\216,\ )Tj -1.372 -1.2 Td (\t\217\212\002\f\001\213\002\004\b\b\013\216 \240\f\235 \002\206\210\201\ \r\b\t\235)Tj 17.385 0.6 Td (\215\r\003\002\240 \215\017)Tj 9.174 0.6 Td (\215\r\003\006\t\220\t \220\004\201\r\217\003\004 )Tj 2.277 -1.2 Td (\214\002\240\r\f\t)Tj /T1_1 1 Tf -49.396 -1.433 Td (Foersch )Tj T* (\f)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. )Tj T* ([17])Tj 6.667 2.4 Td (\202\r\021\024\n\026\021\017\017\030\024\r\026\027\027\026\016 \024\006\ \036\027\022\026 )Tj -0.528 -1.2 Td (\017\n\n\031\027\027\024\020\024 \024\022\030\031\032\036\027\017\016 \024\ \023\031\b\024\035\017)Tj 15.211 1.2 Td (\206\017\f\021\024\035\024\020\017\004\036\f\022\017\036 \f\030\036\t 1\ 108 )Tj 2.531 -1.2 Td (\023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\025\217\217)Tj 15.386 1.2 Td (\225\203\225)Tj 7.047 0 Td (\231\024\004\027\024\f\021\034 $accuracy$)Tj /Span<>> BDC ( )Tj EMC (\227 )Tj 3.488 -1.2 Td (73,5%)Tj -49.802 -2.633 Td (Kleppe )Tj T* (\f)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. )Tj T* ([25])Tj 7.858 2.4 Td (\225\021\030\026\021\017\235\017\022\026\006\017\016 \030\017\f\022\024\r\ )Tj -1.871 -1.2 Td (\023\030\024\020\030\036\f\f\017\030\024\r\026\027\017\016 \026\002\024\ \035\036\r\026\027\017\016 )Tj -0.133 -1.2 Td (\031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (II-III \f\021\026\007\017\036\005 \025\217\217)Tj 16.612 2.4 Td (\206\017\f\021\024\035\024\020\017\004\036\f\022\017\036 \f\030\036\t )Tj -0.515 -1.2 Td (\017)Tj /Span<>> BDC ( )Tj EMC (\023\026\021\024\035\024\020\024\026\027\026\021\024\n\017\004\036\f\022\ \017\036 )Tj -1.318 -1.2 Td (\b\026\030\026\022\021\036\030\017\f\021\017\022\017 2074 \023\026\006\017\ \036\027\021\024\r )Tj 5.525 -1.2 Td (\f)Tj /Span<>> BDC ( )Tj EMC (\025\217\217)Tj 13.109 3.6 Td (\225\203\225)Tj 8.059 0 Td (\203\036 \023\030\036\007\f\021\026\r\035\036\027\t.)Tj -47.326 -5.033 Td (Liu )Tj T* (\f)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. )Tj T* ([29])Tj 7.448 2.4 Td (\215\030\024\020\027\024\017\030\024\r\026\027\017\036 \024\021\r\036\021\ \026 )Tj -1.406 -1.2 Td (\027\026)Tj /Span<>> BDC ( )Tj EMC (\026\007\255\033\r\026\027\021\027\031\033 \b\017\n\017\024\021\036\030\026\ \023\017\033 )Tj 1.568 -1.2 Td (\027\026)Tj /Span<>> BDC ( )Tj EMC (\024\f\027\024\r\036 \235\021\024\030\031\030\026\006\017\035\026, )Tj -1.078 -1.2 Td (\002\036\r\026\006\017\031\n\026\002\026 \017)Tj /Span<>> BDC ( )Tj EMC (\017\027\020\017\002\017\021\024\030\024\r )Tj 2.12 -1.2 Td (\022\024\027\021\030\024\035\034\027\t\b \021\024\004\036\022)Tj 12.412 4.8 Td (\212\026\027\027\t\036 2509 \023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\025\217\217 )Tj 1.228 -1.2 Td (\017)Tj /Span<>> BDC ( )Tj EMC (\024\021\022\030\t\021\t\b \002\026 \007\026\027\027\t\b)Tj 13.718 1.2 Td (\206\210 $\022\035\026\f\021\036\030\017\026\006\017\016$)Tj 10.489 0 Td (\212\035\016 \023\030\024\020\027\024\017\030\024\r\026\027\017\016 )Tj 0.523 -1.2 Td (1, 3-\b \017)Tj /Span<>> BDC ( )Tj EMC (5-\021\017 \035\036\021\027\036\005 )Tj 0.037 -1.2 Td (\r\t\032\017\r\026\036\n\024\f\021\017 AUC )Tj -0.733 -1.2 Td (\f\024\f\021\026\r\017\035\026 0.776, 0.763 )Tj -0.154 -1.2 Td (\017)Tj /Span<>> BDC ( )Tj EMC (0.790 \f\024\024\021\r\036\021\f\021\r\036\027\027\024)Tj -46.175 -1.433 Td (Abraham )Tj 0 -1.2 TD (\f)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. )Tj 0 -1.2 TD ([30])Tj 6.758 2.4 Td (\215\030\036\007\f\022\026\026\027\017\036 \007\035\017\021\036\035\034\ \027\024\f\021\017 )Tj -0.251 -1.2 Td (\023\030\024\n\036\032\031\021\022\024\r \n\036\032\007\031 \022\031\030\ \f\026\n\017, )Tj 1.04 -1.2 Td (\024\002\013\036\005 \017)Tj /Span<>> BDC ( )Tj EMC (\002\036\030\036\006\017\007\017\r\027\024\005 )Tj -0.623 -1.2 Td (\r\t\032\017\r\026\036\n\024\f\021\017 \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r )Tj 0.829 -1.2 Td (\f)Tj /Span<>> BDC ( )Tj EMC (\n\036\021\026\f\021\026\021\017\004\036\f\022\017\n \025\217\217, )Tj -2.183 -1.2 Td (\023\024\035\031\004\026\033\013\017\b \216\231 \f)Tj /Span<>> BDC ( )Tj EMC (\024\022\f\026\035\017\023\035\026\021\017\027\024\n)Tj 16.171 6 Td (\217\036\031\035\034\021\026\021\t \n\024\035\036\022\031\035\016\030\027\ \024\020\024 )Tj -0.295 -1.2 Td (\023\030\024\235\017\035\017\030\024\r\026\027\017\016 \023\026\006\017\036\ \027\021\024\r )Tj -0.003 Tw -0.895 -1.2 Td (\f)Tj /Span<>> BDC ( )Tj EMC (\025\217\217, 599 \017)Tj /Span<>> BDC ( )Tj EMC (\017\f\f\035\036\007\024\r\026\027\017\016 RWE, )Tj 0 Tw 0.831 -1.2 Td (272 \017)Tj /Span<>> BDC ( )Tj EMC (\017\f\f\035\036\007\024\r\026\027\017\016 TRIBE2)Tj 14.713 3.6 Td (\025\024\n\023\035\036\022\f \n\036\021\024\007\024\r: )Tj -1.286 -1.2 Td (\f\035\031\004\026\005\027\t\005 \035\036\f $\225\214$, \204\210\200, \ )Tj 0.043 -1.2 Td (\035\024\020\017\f\021\017\004\036\f\022\026\016 \030\036\020\030\036\f\f\ \017\016 )Tj 0.839 -1.2 Td ($\214\217$, \026\027\026\035\017 \020\035\026\r\027\t\b )Tj 2.146 -1.2 Td (\022\024\n\023\024\027\036\027\021)Tj 9.519 4.8 Td (\244\031\r\f\021\r\017\021\036\035\034\027\024\f\021\034 )Tj -1.259 -1.2 Td (88,3% \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\024\023\030\036\007\036\035\036\027\017\017 )Tj 0.006 -1.2 Td (\n\024\035\036\022\031\035\016\030\027\024\020\024 \023\024\007\021\017\023\ \026 )Tj 3.975 -1.2 Td (\030\026\022\026)Tj -50.079 -3.833 Td (Xu Y )Tj 0 -1.2 TD (\f)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. )Tj T* ([34])Tj 6.92 2.4 Td (\215\030\024\020\027\024 \023\030\024\020\030\036\f\f\017\030\024\r\026\ \027\017\016 )Tj 1.714 -1.2 Td (\026\002\024\035\036\r\026\027\017\016 \023\024\f\035\036 )Tj -1.114 -1.2 Td (\b\017\030\031\030\020\017\004\036\f\022\024\020\024 \035\036\004\036\027\ \017\016)Tj 13.391 2.4 Td (\025\035\017\027\017\004\036\f\022\017\036 \007\026\027\027\t\036 \017)Tj /Span<>> BDC ( )Tj EMC (\007\026\027\027\t\036 )Tj 1.222 -1.2 Td (\023\026\021\024\035\024\020\024\026\027\026\021\024\n\017\004\036\f\022\ \024\020\024 )Tj -0.877 -1.2 Td (\017\f\f\035\036\007\024\r\026\027\017\016 999 \023\026\006\017\036\027\021\ \024\r )Tj 4.902 -1.2 Td (\f)Tj /Span<>> BDC ( )Tj EMC (\025\217\217)Tj -0.036 Tw 8.566 3.6 Td (\214\024\020\017\f\021\017\004\036\f\022\026\016 \030\036\020\030\036\f\f\ \017\016, )Tj 0 Tw 0.787 -1.2 Td (\007\036\030\036\r\024 \030\036\001\036\027\017\005 $\212\217$, )Tj 0.06 -1.2 Td (\020\030\026\007\017\036\027\021\027\t\005 \002\031\f\021\017\027\020, )Tj 2.638 -1.2 Td (lightGBM)Tj 8.039 3.6 Td (AUC)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,761 \007\035\016 \n\036\021\024\007\026 )Tj 0.05 -1.2 Td (\020\030\026\007\017\036\027\021\027\024\020\024 \002\031\f\021\017\027\020\ \026)Tj -46.299 -3.833 Td (Han T )Tj T* (\f)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. )Tj T* ([35])Tj 6.536 2.4 Td (\215\030\036\007\f\022\026\026\027\017\036 \030\017\f\022\026 \027\026\035\ \017\004\017\016 )Tj -0.029 -1.2 Td (\n\036\021\026\f\021\017\021\017\004\036\f\022\024\020\024 \023\024\030\026\ \032\036\027\017\016 )Tj -0.758 -1.2 Td (\023\036\004\036\027\017 \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (T1-\f\021\026\007\017\036\005)Tj 15.163 2.4 Td (\025\035\017\027\017\004\036\f\022\017\036 \007\026\027\027\t\036 \017)Tj /Span<>> BDC ( )Tj EMC (\007\026\027\027\t\036 )Tj 1.222 -1.2 Td (\023\026\021\024\035\024\020\024\026\027\026\021\024\n\017\004\036\f\022\ \024\020\024 )Tj -1.494 -1.2 Td (\017\f\f\035\036\007\024\r\026\027\017\016 17 111 \023\026\006\017\036\027\ \021\024\r )Tj 5.518 -1.2 Td (\f)Tj /Span<>> BDC ( )Tj EMC (\025\217\217)Tj 11.145 3.6 Td (\212\217, \002\031\021\f\021\030\220\023-)Tj -0.419 -1.2 Td (\026\020\030\036\020\017\030\024\r\026\027\017\036, )Tj -1.57 -1.2 Td (\026\027\f\026\n\002\035\036\r\024\036 \024\002\031\004\036\027\017\036)Tj 13.348 2.4 Td (\203\026\017\r\t\f\001\026\016 )Tj -0.775 -1.2 Td (\017)Tj /Span<>> BDC ( )Tj EMC (\007\024\f\021\017\020\027\031\021\t\b )Tj 0.504 -1.2 Td (AUC)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,9631)Tj -48.391 -2.633 Td (El\243ky )Tj T* (\f)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. )Tj 0 -1.2 TD ([36])Tj 6.577 2.4 Td (\215\030\036\007\f\022\026\026\027\017\036 30-\021\017 \007\027\036\r\027\ \024\005 )Tj 0.634 -1.2 Td (\035\036\021\026\035\034\027\024\f\021\017 \023\024\f\035\036 \027\026\004\ \026\035\026 )Tj 2.418 -1.2 Td (\b\017\n\017\024\021\036\030\026\023\017\017)Tj 11.283 2.4 Td (\025\035\017\027\017\004\036\f\022\017\036 \007\026\027\027\t\036 \017)Tj /Span<>> BDC ( )Tj EMC (\007\026\027\027\t\036 )Tj 1.222 -1.2 Td (\023\026\021\024\035\024\020\024\026\027\026\021\024\n\017\004\036\f\022\ \024\020\024 )Tj -1.448 -1.2 Td (\017\f\f\035\036\007\024\r\026\027\017\016, \024\002\255\036\n \007\026\027\ \027\t\b \027\036 )Tj 5.213 -1.2 Td (\031\022\026\026\027)Tj 10.434 3.6 Td (\212\217 \f)Tj /Span<>> BDC ( )Tj EMC (\020\030\026\007\017\036\027\021\027\t\n )Tj 1.588 -1.2 Td (\002\031\f\021\017\027\020\024\n)Tj 10.72 1.2 Td (AUC)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,924)Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\205)10(\210\036\033 \035\030\032\204\033)30(\021)42(\032)-21(\211\033\237)]TJ 57.136 0 Td (REVIEW)Tj /T1_4 1 Tf 25 0 0 25 505.527 56.0378 Tm (189)Tj ET endstream endobj 281 0 obj <> endobj 279 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.061 Tw 10 0 0 10 70.8661 724.8299 Tm (\020\030\031\023\023\t \n\036\021\024\007\017\022 \r)Tj /Span<>> BDC ( )Tj EMC (\027\026\f\021\024\016\013\017\005 \023\036\030\017\024\007 \r\030\036\n\ \036\027\017 \n\024\032\036\021 )Tj -0.002 Tw 0 -1.218 TD (\002\t\021\034 \f\021\024\017\n\024\f\021\034 \020\036\027\036\021\017\004\ \036\f\022\017\b \017\f\f\035\036\007\024\r\026\027\017\005. \200)Tj /Span<>> BDC ( )Tj EMC (\017\f\f\035\036)Tj 0 Tw (-)Tj 0.116 Tw T* [(\007\024\r\026\027\017\017 A)-14(br)-33(aham c \f\024\026\r\021. [30] \017\f\023\024\035\034\024\r\026\035\026\f\ \034 \f\017\020)]TJ 0 Tw (-)Tj 0.017 Tw T* (\027\026\021\031\030\026 \017)Tj /Span<>> BDC ( )Tj EMC (67 \020\036\027\024\r \007\035\016 \023\030\036\007\f\022\026\026\027\017\ \016 \220\235\235\036\022\021\017\r\027\024\f\021\017 )Tj 0.056 Tw T* (\b\017\n\017\024\021\036\030\026\023\017\017 \027\026)Tj /Span<>> BDC ( )Tj EMC (\024\f\027\024\r\036 \024\022\f\026\035\017\023\035\026\021\017\027\026 \ \r)Tj /Span<>> BDC ( )Tj EMC (\f\024\004\036\021\026\027\017\017 )Tj -0.035 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\002\036\r\026\006\017\031\n\026\002\024\n \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\n\036\021\026\f\021\026\021\017\004\036\f\022\017\n \025\217\217. )Tj 0 Tw 0 -1.218 TD [(\204\024\007\036\035\034 \023\024\035\031\004\017\035\026 \027\026\r\026\ \027\017\036 FOLFO)17.2(X)-13.9(ai [30].)]TJ 0.207 Tw 0 -1.218 TD (\225\031\013\036\f\021\r\031\036\021 \030\016\007 \030\026\002\024\021, \ \r)Tj /Span<>> BDC ( )Tj EMC (\022\024\021\024\030\t\b \204\210 \017\f\023\024\035\034\024\r\026\035\017\ )Tj -0.033 Tw T* [(\007\035\016 \023\030\024\020\027\024\017\030\024\r\026\027\017\016 )0.5(\021\036\030\026\023\036\r\021\017\004\036\f\022\024\020\024 \220\235\235\ \036\022\021\026 \021\026\030)]TJ 0 Tw (-)Tj 0.049 Tw T* [(\020\036\021\027\024\005 )0.5(\b\017\n\017\024\021\036\030\026\023\017\017. )0.5(\200)]TJ /Span<>> BDC ( )Tj EMC [(\017\f\f\035\036\007\024\r\026\027\017\017 )0.5(Giannini \f)]TJ /Span<>> BDC ( )Tj EMC (\f\024)Tj 0 Tw (-)Tj -0.04 Tw T* (\026\r\021\024\030\026\n\017 \023\t\021\026\035\017\f\034 \017\f\023\024\ \035\034\024\r\026\021\034 \n\024\007\036\035\034 \206\210 \007\035\016\ \023\030\036\007)Tj 0 Tw (-)Tj 0.589 Tw T* (\f\022\026\026\027\017\016 \220\235\235\036\022\021\017\r\027\024\f\021\ \017 \035\036\004\036\027\017\016 \021\030\026\f\021\031\031\n\026\002\024\ \n )Tj -0.023 Tw 0 -1.218 TD (\017)Tj /Span<>> BDC ( )Tj EMC (\035\026\023\026\021\017\027\017\002\024\n \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (HER2-\023\024\017\021\017\r\027\t\n \n\036\021\026)Tj 0 Tw (-)Tj 0.1 Tw 0 -1.218 TD [(\f\021\026\021\017\004\036\f\022\017\n )0.5(\025\217 [31]. )0.5(\200)]TJ /Span<>> BDC ( )Tj EMC [(\030\036\031\035\034\021\026\021\036 )0.5(\024\002\031\004\036\027\017\016 )0.5(\n\024\007\036\035\017 )]TJ 0.174 Tw 0 -1.218 TD (\031\007\026\035\024\f\034 \007\024\f\021\017\020\027\031\021\034 90% \004\ \031\r\f\021\r\017\021\036\035\034\027\024\f\021\017 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (42% )Tj 0 Tw T* (\f\023\036\006\017\235\017\004\027\024\f\021\017 [31].)Tj /T1_1 1 Tf 0.205 Tw 0 -2.436 TD (2.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (\207\033\034\013\020\034\031\022\033\034\036\037\020\022\016 \033\022\024\ \021\034\036 \034\035\004\037\027\016\020\020\034\013\034 \003\016\035\037\ \024\035\037)Tj 0 Tw (-)Tj -1.296 -1.218 Td (\031\022\033\034\036\037\020\022\030 \022)Tj /Span<>> BDC ( )Tj EMC (\033\016\n\022\004\022\036\037 \031\037\025\034\027\016\036\037\020\022\030\ )Tj /T1_0 1 Tf 0.012 Tw 0 -1.218 TD (\213\013\036 \024\007\027\024\005 \017)Tj /Span<>> BDC ( )Tj EMC (\r\026\032\027\t\b \023\030\024\002\035\036\n \035\036\004\036\027\017\016\ \025\217\217, \022\024\021\024\030\031\033 )Tj 0.191 Tw T* (\023\t\021\026\033\021\f\016 \030\036\001\017\021\034 \f)Tj /Span<>> BDC ( )Tj EMC (\023\024\n\024\013\034\033 \021\036\b\027\024\035\024\020\017\005 \224\224\ , \016\r\035\016)Tj 0 Tw (-)Tj 0.147 Tw T* (\036\021\f\016 \023\030\024\020\027\024\017\030\024\r\026\027\017\036 \r\ \036\030\024\016\021\027\024\f\021\017 \030\036\006\017\007\017\r\026. \211\ )Tj /Span<>> BDC ( )Tj EMC (\023\026)Tj 0 Tw (-)Tj 0.112 Tw T* [(\006\017\036\027\021\024\r )0.6(\f)]TJ /Span<>> BDC ( )Tj EMC 4.484 0 Td [(\025\217\217 )0.6(II )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC 3.88 0 Td [(III )0.6(\f\021\026\007\017\017 )0.6(\022\031\n\031\035\016\021\017\r\027\026\016 )0.6(\004\026\f\021\024\021\026 )]TJ 0.069 Tw -8.364 -1.218 Td (\n\036\f\021\027\t\b \030\036\006\017\007\017\r\024\r \026)Tj /Span<>> BDC ( )Tj EMC (5 \035\036\021 \023\024\f\035\036 \024\023\036\030\026\006\017\017 \f\024\ \f\021\026\r)Tj 0 Tw (-)Tj -0.033 Tw T* [(\035\016\036\021 )0.5(11,0% )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 5.354 0 Td [(23,5%, )0.5(\f\024\024\021\r\036\021\f\021\r\036\027\027\024 )0.6([32]. )0.5(\200)]TJ /Span<>> BDC ( )Tj EMC 12.427 0 Td (\007\024\f\021\031\023\027\t\b )Tj 0.115 Tw -17.781 -1.218 Td (\030\026\002\024\021\026\b \026\004\026\f\021\031\033 \007\035\016 \023\ \024\f\021\030\024\036\027\017\016 \n\024\007\036\035\017 \017\f\023\024\ \035\034\031)Tj 0 Tw (-)Tj 0.023 Tw T* (\033\021\f\016 \030\026\007\017\024\n\027\t\036 \023\030\017\027\026\022\ \017, \017\r\035\036\022\026\036\n\t\036 \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\036\007\024\023\036)Tj 0 Tw (-)Tj 0.044 Tw T* [(\030\026\006\017\024\027\027\024\020\024 )0.5(\025\231-\017\024\002\030\026\032\036\027\017\016 )0.5(\024\023\031\b\024\035\017. )0.6(\213\007\017\027\f\021\r\036\027\027\024\005 )]TJ 0.021 Tw T* [(\022\035\017\027\017\004\036\f\022\024\005 )0.5(\023\036\030\036\n\036\027\027\024\005 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC [(\017\f\f\035\036\007\024\r\026\027\017\017 )0.5(Badic \f)]TJ /Span<>> BDC ( )Tj EMC (\f\024)Tj 0 Tw (-)Tj 0.094 Tw T* (\026\r\021. \002\t\035\024 \027\026\035\017\004\017\036 \035\017\002\024\ \024\021\f\031\021\f\021\r\017\036 \026\007\255\033\r\026\027\021\027\024\ \005 \216\231, )Tj 0.034 Tw T* (\023\030\017)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\n R-\f\021\026\021\031\f \024\023\031\b\024\035\017 \023\024\ \f\035\036 \024\023\036\030\026\006\017\017 \027\036 \017\f\f\035\036)Tj 0 Tw (-)Tj T* (\007\024\r\026\035\f\016 [33].)Tj 0.287 Tw T* (\037\036\035\034\033 \007\030\031\020\024\020\024 \017\f\f\035\036\007\024\ \r\026\027\017\016, \r\t\023\024\035\027\036\027\027\024\020\024 Xu)Tj /Span<>> BDC ( )Tj EMC (Y. )Tj 0.242 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021., \002\t\035\024 \017\031\004\036\027\017\036 \r\024\n\ \024\032\027\024\f\021\017 \017\f\023\024\035\034\024\r\026)Tj 0 Tw (-)Tj 0.06 Tw T* (\027\017\016 \021\036\b\027\024\035\024\020\017\017 \204\210 \007\035\016\ \023\030\024\020\027\024\017\030\024\r\026\027\017\016 \030\017\f\022\026\ \023\030\024)Tj 0 Tw (-)Tj 0.259 Tw T* (\020\030\036\f\f\017\017 \026\002\024\035\036\r\026\027\017\016 \023\024\ \f\035\036 \024\023\036\030\026\006\017\017 \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r )Tj 0.295 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC [(IV \f\021\026\007\017\036\005 \025\217\217 [34]. A)17(UC \n\024\007\036\035\017 \020\030\026\007\017\036\027\021\027\024\020\024\ )]TJ 0.466 Tw T* [(\002\031\f\021\017\027\020\026 )0.6(\007\035\016 )0.5(\023\030\024\020\027\024\017\030\024\r\026\027\017\016 )0.5(\023\030\024\020\030\036\f\f\017\030\024\r\026\027\017\016 )]TJ 0.325 Tw T* (\030\026\022\026 \f\024\f\021\026\r\017\035\024 0,734. \215\030\017)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\n \r\036\f\024\r\026\016 \n\026\021\030\017\006\026 )Tj 0.137 Tw T* [(\026\035\020\024\030\017\021\n\026 )0.5(\023\024\022\026\026\035\026, )0.6(\004\021\024 )0.5(\b\017\n\017\024\021\036\030\026\023\017\016, )0.6(\r\024\030\026\f\021, )0.5(\027\026)]TJ 0 Tw (-)Tj 0.031 Tw T* (\021\031\030\026\035\034\027\t\005 \035\024\020\026\030\017\235\n \022\024\ \027\006\036\027\021\030\026\006\017\017 \217\230\202, \217\230\202 \017\ )Tj /Span<>> BDC ( )Tj EMC (\r\030\036\n\016 )Tj 0.156 Tw T* (\026\027\036\f\021\036\017\017 \002\t\035\017 \023\016\021\034\033 \027\ \026\017\002\024\035\036\036 \027\026\004\017\n\t\n\017 \235\026\022\021\ \024)Tj 0 Tw (-)Tj -0.008 Tw T* (\030\026\n\017 \030\017\f\022\026 \023\030\024\020\030\036\f\f\017\030\024\ \r\026\027\017\016 \026\002\024\035\036\r\026\027\017\016, \023\030\017\ )Tj /Span<>> BDC ( )Tj EMC (\220\021\024\n )Tj 0.243 Tw T* (\036\007\017\027\f\021\r\036\027\027\t\n \253\b\017\030\031\030\020\017\004\ \036\f\022\017\n\273 \023\026\030\026\n\036\021\030\024\n, \r\022\035\033\ )Tj 0 Tw (-)Tj 0.185 Tw T* (\004\036\027\027\t\n \r)Tj /Span<>> BDC ( )Tj EMC (\026\027\026\035\017, \002\t\035 \007\024\f\021\031\023 $\035\026\023\026\ \030\024\f\022\024\023\017\004\036\f\022\017\005/)Tj 0 Tw T* (\021\030\026\007\017\006\017\024\027\027\t\005$)Tj /Span<>> BDC ( )Tj EMC ([34].)Tj 0.322 Tw T* [(\200 \036\013\036 \024\007\027\024\n \017\f\f\035\036\007\024\r\026\027\017\ \017, \026\f\035\031\032\017\r\026\033\013\036\n )0.5(\r\027\017)]TJ 0 Tw (-)Tj 0.203 Tw T* (\n\026\027\017\016 $Han T. \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021.$, \002\t\035\026 \f\024\007\026\027\026 \n\024\007\036\ \035\034 \007\035\016 )Tj 0.322 Tw T* (\023\030\024\020\027\024\017\030\024\r\026\027\017\016 \n\036\021\026\f\ \021\026\021\017\004\036\f\022\024\020\024 \023\024\030\026\032\036\027\017\ \016 \023\036)Tj 0 Tw (-)Tj 0.007 Tw T* (\004\036\027\017 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\2311 \025\217\217. \200)Tj /Span<>> BDC ( )Tj EMC (\024\002\013\036\005 \f\035\024\032\027\024\f\021\017 \r)Tj /Span<>> BDC ( )Tj EMC (\017\f\f\035\036\007\024\r\026\027\017\036 )Tj 0.076 Tw T* (\002\t\035\017 \r\022\035\033\004\036\027\t 16 785 \023\026\006\017\036\027\ \021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\025\217\217, \017)Tj /Span<>> BDC ( )Tj EMC (\022\024\021\024\030\t\b )Tj 0.134 Tw T* (\031)Tj /Span<>> BDC ( )Tj EMC 0.812 0 Td [(326 )0.5(\002\t\035\026 \2311 )0.5(\f\021\026\007\017\016 )0.5(\024\023\031\b\024\035\017 )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC 13.305 0 Td [(\2041 )0.5(\031)]TJ /Span<>> BDC ( )Tj EMC [(\r\024\f\034\n\017 )0.5(\023\026\006\017)]TJ 0 Tw (-)Tj 0.042 Tw -14.117 -1.218 Td (\036\027\021\024\r [35]. \200)Tj /Span<>> BDC ( )Tj EMC (\030\036\031\035\034\021\026\021\036 \002\t\035\024 \023\024\022\026\026\ \027\024, \004\021\024 \r\024\030\026\f\021, )Tj 0.239 Tw T* (\023\024\035, \f\036\n\036\005\027\024\036 \023\024\035\024\032\036\027\017\ \036, \023\036\030\r\017\004\027\026\016 \035\024\022\026\035\017\026\006\ \017\016, )Tj 0.274 Tw 23.244 64.543 Td [(\030\026\n\036\030 \024\023\031\b\024\035\017, )0.5(\217\230\202, )0.5(\021\017\023 \024\023\031\b\024\035\017, )0.5(\f\021\036\023\036\027\034 \035\024\022\026)]TJ 0 Tw (-)Tj 0.267 Tw T* (\004\036\f\021\r\036\027\027\024\f\021\017, N-\f\021\026\007\017\016 \017\ )Tj /Span<>> BDC ( )Tj EMC (\023\036\030\017\027\036\r\030\026\035\034\027\026\016 \017\027\r\026\017\ \016 )Tj 0.192 Tw T* (\002\t\035\017 \030\036\001\026\033\013\017\n\017 \235\026\022\021\024\030\ \026\n\017 \007\035\016 \023\030\024\020\027\024\017\030\024\r\026\027\017\ \016 )Tj 0.096 Tw T* (\n\036\021\026\f\021\026\021\017\004\036\f\022\024\020\024 \023\024\030\026\ \032\036\027\017\016, \f\030\036\007\017 \022\024\021\024\030\t\b \030\026\ \n\036\030 )Tj 0.243 Tw T* [(\024\023\031\b\024\035\017 \017\n\036\035 \027\026\017\002\024\035\034\001\ \036\036 \027\026\004\036\027\017\036 [35]. A)17(UC \023\024)]TJ 0 Tw (-)Tj T* (\f\021\030\024\036\027\027\024\005 \n\024\007\036\035\017 \002\t\035\026\ \002\035\017\022\026 \022)Tj /Span<>> BDC ( )Tj EMC (0,95 [35].)Tj /T1_1 1 Tf -0.032 Tw 0 -2.436 TD (3.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (\207\033\034\013\020\034\031\022\033\034\036\037\020\022\016 \022\020\032\ \022\024\034\004\034\036 \020\037)Tj /Span<>> BDC ( )Tj EMC (\034\024\020\034\036\016 \021\027\022\020\022\201\016)Tj 0 Tw (-)Tj -1.296 -1.218 Td (\024\021\022 \022)Tj /Span<>> BDC ( )Tj EMC (\027\037\025\034\033\037\035\034\033\020\032 \004\037\020\020\032)Tj /T1_0 1 Tf 0.015 Tw 0 -1.218 TD (\215\030\017 \r\t\002\024\030\036 \035\036\004\036\027\017\016 \023\026\006\ \017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\025\217\217 \n\024\007\036\035\017 \204\210, \024\f)Tj 0 Tw (-)Tj 0.207 Tw T* (\027\024\r\026\027\027\t\036 \027\026)Tj /Span<>> BDC ( )Tj EMC (\022\035\017\027\017\004\036\f\022\017\b \017)Tj /Span<>> BDC ( )Tj EMC (\035\026\002\024\030\026\021\024\030\027\t\b \007\026\027\027\t\b, )Tj -0.026 Tw 0 -1.218 TD (\n\024\020\031\021 \023\024\n\024\004\034 \024\023\030\036\007\036\035\017\ \021\034 \022\026\022 \023\030\036\017\n\031\013\036\f\021\r\026, \021\026\ \022 \017)Tj /Span<>> BDC ( )Tj EMC (\030\017)Tj 0 Tw (-)Tj 0.047 Tw 0 -1.218 TD (\f\022\017 \b\017\n\017\024\021\036\030\026\023\017\017 \026)Tj /Span<>> BDC ( )Tj EMC (\f\004\036\021 \023\030\024\020\027\024\017\030\024\r\026\027\017\016 \r\ \024\n\024\032)Tj 0 Tw (-)Tj 0 -1.218 TD (\027\t\b \017\f\b\024\007\024\r \035\036\004\036\027\017\016.)Tj 0.128 Tw 0 -1.218 TD [(\200 \017\f\f\035\036\007\024\r\026\027\017\017 El\243k)-32(y \f)]TJ /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. \026\035\020\024\030\017\021\n \n\026\001\017\027\027\024\ \020\024 )Tj 0.174 Tw 0 -1.218 TD (\024\002\031\004\036\027\017\016, \023\030\017\n\036\027\016\036\n\t\005\ \022)Tj /Span<>> BDC ( )Tj EMC (\007\026\027\027\t\n \220\035\036\022\021\030\024\027\027\024\005 \n\036\ )Tj 0 Tw (-)Tj 0.226 Tw 0 -1.218 TD [(\007\017\006\017\027\f\022\024\005 )0.6(\022\026\030\021\t, )0.5(\002\t\035 )0.5(\024\002\031\004\036\027 )0.5(\007\035\016 )0.6(\023\030\036\007\f\022\026\t\r\026\027\017\016 )]TJ 0.27 Tw 0 -1.218 TD (30-\007\027\036\r\027\024\005 \035\036\021\026\035\034\027\024\f\021\017\ \027\026)Tj /Span<>> BDC ( )Tj EMC (\n\024\n\036\027\021 \027\026\004\026\035\026 \b\017\n\017\024)Tj 0 Tw (-)Tj 0.457 Tw 0 -1.218 TD [(\021\036\030\026\023\017\017. \025\035\033\004\036\r\t\n\017 )0.5(\023\030\036\007\017\022\021\024\030\026\n\017 \002\t\035\017 \017\027\007\ \036\022\f )]TJ 0.252 Tw 0 -1.218 TD (\022\024\n\024\030\002\017\007\027\024\f\021\017, \r\024\030\026\f\021,\ \004\026\f\021\024\021\026 \f\036\030\007\036\004\027\t\b \f\024\022\030\ \026)Tj 0 Tw (-)Tj 0.315 Tw T* (\013\036\027\017\005 \017)Tj /Span<>> BDC ( )Tj EMC (\030\016\007 \035\026\002\024\030\026\021\024\030\027\t\b \023\024\022\026\ \026\021\036\035\036\005 $\031\030\024\r\036\027\034 )Tj 0.13 Tw 0 -1.218 TD (\225-\030\036\026\022\021\017\r\027\024\020\024 \002\036\035\022\026, \022\ \024\035\017\004\036\f\021\r\024 \035\036\005\022\024\006\017\021\024\r \ \r)Tj /Span<>> BDC ( )Tj EMC (\022\030\024)Tj 0 Tw (-)Tj 0.083 Tw 0 -1.218 TD (\r\017 \017)Tj /Span<>> BDC ( )Tj EMC (\031\030\024\r\036\027\034 \013\036\035\024\004\027\024\005 \235\024\f\235\ \026\021\026\t$ [36]. \200\026\032\027\024 \024\021)Tj 0 Tw (-)Tj 0.095 Tw 0 -1.218 TD (\n\036\021\017\021\034, \004\021\024 \027\017 \024\007\017\027 \017)Tj /Span<>> BDC ( )Tj EMC (\235\026\022\021\024\030\024\r \027\036 \024\002\255\016\f\027\016\035 \002\ \024\035\036\036 )Tj 0.17 Tw T* (2% \023\030\024\020\027\024\024\r \n\024\007\036\035\017 \035\017\027\036\ \005\027\t\n \024\002\030\026\024\n. \207\024\035\034\001\026\016 )Tj 0.082 Tw T* [(\004\026\f\021\034 )0.5(\r\026\030\017\026\006\017\005 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 7.571 0 Td [(\023\030\024\020\027\024\026\b )0.6($86,4%$ )0.5(\027\036 )0.5(\002\t\035\026 )0.5(\035\017\027\036\005)]TJ 0 Tw (-)Tj 0.329 Tw -7.571 -1.218 Td [(\027\024\005 \235\031\027\022\006\017\036\005 \022\026\022\024\020\024-\035\ \017\002\024 )0.5(\024\021\007\036\035\034\027\024\020\024 \023\026\030\026\n\036\021\030\026\ , )]TJ 0.265 Tw T* (\004\021\024 \031\022\026\t\r\026\036\021 \027\026)Tj /Span<>> BDC ( )Tj EMC (\021\024, \004\021\024 \n\024\007\036\035\034 \007\036\030\036\r\026 \023\ \030\017\027\016\021\017\016 )Tj 0.322 Tw 0 -1.218 TD (\030\036\001\036\027\017\005 \r)Tj /Span<>> BDC ( )Tj EMC [(\027\026\004\017\021\036\035\034\027\024\005 )0.5(\f\021\036\023\036\027\017 \f\024\024\021\r\036\021\f\021\r\024\r\026\035\ \026 )]TJ 0.149 Tw 0 -1.218 TD [(\f\035\024\032\027\t\n \027\036\035\017\027\036\005\027\t\n )0.5(\r\026\017\n\024\007\036\005\f\021\r\017\016\n \n\036\032\007\031 )0.5(\r\f\036)]TJ 0 Tw (-)Tj 0.028 Tw 0 -1.218 TD [(\n\017 \022\035\017\027\017\004\036\f\022\017\n\017 \023\024\022\026\026\ \021\036\035\016\n\017 [36]. A)17(UC \024\023\017\f\026\027\027\024\005 )]TJ 0 Tw T* (\n\024\007\036\035\017 \f\024\f\021\026\r\017\035 0,810 [36].)Tj 0.483 Tw T* (\225\030\026\r\027\017\021\036\035\034\027\024 \027\024\r\t\n \023\024\007\ \b\024\007\024\n \022)Tj /Span<>> BDC ( )Tj EMC (\235\024\030\n\017\030\024\r\026\027\017\033 )Tj 0.339 Tw T* (\023\030\024\020)Tj /Span<>> BDC ( )Tj EMC 1.873 0 Td (\027\024\027\t\b \n\024\007\036\035\036\005 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\025\217\217 \f\021\026\027\024\r\017\021\f\016 \021\026\022 \027\026)Tj 0 Tw (-)Tj 0.114 Tw -1.873 -1.218 Td (\t\r\026\036\n\t\005 \253\n\031\035\034\021\017\024\n\027\t\005 \023\024\ \007\b\024\007\273, \020\007\036 \027\026\030\016\007\031 \022)Tj /Span<>> BDC ( )Tj EMC (\031\032\036 )Tj 0.151 Tw 0 -1.218 TD [(\024\023\017\f\026\027\027\t\n )0.6(\023\026\030\026\n\036\021\030\026\n )0.5(\036\013\036 )0.6(\007\024\002\026\r\035\036\027 )0.5(\023\026\030\026\n\036\021\030 )0.5(\022\017)]TJ 0 Tw (-)Tj 0.139 Tw 0 -1.218 TD (\001\036\004\027\024\005 \n\017\022\030\024\002\017\024\021\t [37]. \203\ \026)Tj /Span<>> BDC ( )Tj EMC (\027\036\002\024\035\034\001\024\005 \023\024)Tj /Span<>> BDC ( )Tj EMC (\024\002\255\036\n\031 )Tj 0.238 Tw 0 -1.218 TD [(\r\t\002\024\030\022\036 )0.6($78 )0.5(\023\026\006\017\036\027\021\024\r$ )0.6(\026\r\021\024\030\t )0.5(\023\024\007 )0.6(\030\031\022\024\r\024\007\f\021\r\024\n )]TJ 0.304 Tw 0 -1.218 TD [(Y)50(ang \024\023\030\036\007\036\035\017\035\017 )0.5(\n\017\022\030\024\002\027\t\036 \026\f\f\024\006\017\026\006\017\017, \022\ \024\021\024\030\t\036 )]TJ -0.024 Tw 0 -1.218 TD (\n\024\020\031\021 \017\f\023\024\035\034\024\r\026\021\034\f\016 \r)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\020\027\024\027\t\b \n\024\007\036\035\016\b \r\t\032\017\r\ \026)Tj 0 Tw (-)Tj 0 -1.218 TD (\036\n\024\f\021\017 \023\026\006\017\036\027\021\024\r \025\217\217 [37\ ].)Tj 0.053 Tw T* (\224\027\235\024\030\n\026\006\017\016 \024)Tj /Span<>> BDC ( )Tj EMC (\027\026\017\002\024\035\036\036 \023\036\030\f\023\036\022\021\017\r\027\ \t\b \017)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\036\004\017\f)Tj 0 Tw (-)Tj 0.131 Tw T* (\035\036\027\027\t\b \r\t\001\036 \n\024\007\036\035\036\005 \007\035\016\ \023\030\024\020\027\024\017\030\024\r\026\027\017\016 \022\035\017\027\ \017)Tj 0 Tw (-)Tj 0 -1.218 TD (\004\036\f\022\017\b \017\f\b\024\007\024\r \023\030\036\007\f\021\026\r\ \035\036\027\026 \r)Tj /Span<>> BDC ( )Tj EMC (\021\026\002\035\017\006\036 1.)Tj /T1_1 1 Tf 0 -2.436 TD (4.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (\200\200 \004\027\030 \034\n\016\020\021\022 \035\034\021\024\022\201\020\ \034\024\035\022 \022\003\022\034\035\016\033\037\f\022\022)Tj /T1_0 1 Tf -0.012 Tw -1.296 -1.218 Td (\200 \030\016\007\036 \017\f\f\035\036\007\024\r\026\027\017\005 \204\210\ \017\f\023\024\035\034\024\r\026\035\024\f\034 \007\035\016 \023\030\024\ \020\027\024)Tj 0 Tw (-)Tj 0.08 Tw 0 -1.218 TD (\017\030\024\r\026\027\017\016 \021\024\022\f\017\004\027\024\f\021\017\ \b\017\n\017\024\021\036\030\026\023\017\017. \200)Tj /Span<>> BDC ( )Tj EMC (\017\f\f\035\036\007\024\r\026)Tj 0 Tw (-)Tj -0.003 Tw 0 -1.218 TD [(\027\017\017 L)-32(i C. \f)]TJ /Span<>> BDC ( )Tj EMC (\f\024\026\r\021., \027\026)Tj /Span<>> BDC ( )Tj EMC (\r\t\002\024\030\022\036 36 030 \023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\025\217\217 )Tj 0.192 Tw 0 -1.218 TD (\023\024\035\031\004\026\r\001\017\b \235\021\024\030\023\017\030\017\n\017\ \007\017\027, \017\f\023\024\035\034\024\r\026\035\017\f\034 \n\024\007\ \036)Tj 0 Tw (-)Tj 0.189 Tw 0 -1.218 TD (\035\017 \214\217, \225\214 \017)Tj /Span<>> BDC ( )Tj EMC (\220\022\f\021\030\036\n\026\035\034\027\024\020\024 \020\030\026\007\017\ \036\027\021\027\024\020\024 \002\031\f\021\017\027\020\026 )Tj 0.002 Tw 0 -1.218 TD ($\230\206\207$ \f)Tj /Span<>> BDC ( )Tj EMC 3.109 0 Td [(\n\026\022\f\017\n\026\035\034\027\024\005 )0.5(\021\024\004\027\024\f\021\034\033 )0.5(\031)]TJ /Span<>> BDC ( )Tj EMC [(\023\024\f\035\036\007\027\036\005 )0.5(\n\024\007\036\035\017 )]TJ 0.157 Tw -3.109 -1.218 Td (0,816 [11]. \200)Tj /Span<>> BDC ( )Tj EMC (\030\036\031\035\034\021\026\021\036 \235\026\022\021\024\030\026\n\017\ \030\017\f\022\026 30-\007\027\036\r)Tj 0 Tw (-)Tj -0.026 Tw 0 -1.218 TD [(\027\024\005 \022\026\030\007\017\024\021\024\022\f\017\004\027\024\f\021\ \017 )0.5(\002\t\035\017: \030\026\027\036\036 \f\031\013\036\f\021\r\024\r\026\r\001\ \017\036 )]TJ 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0 Tw 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\205)10(\210\036\033 \035\030\032\204\033)30(\021)42(\032)-21(\211\033\237)]TJ 57.136 0 Td (REVIEW)Tj -57.136 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 23, \023\0222, 202)69(4)]TJ 42.99 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 23, \023\0222, 202)69(4)]TJ /T1_3 1 Tf 25 0 0 25 20.8152 56.0378 Tm (188)Tj ET endstream endobj 278 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\240\025)21(\220\024\025\226\004\025\r)-9.9(\026\005 \005\022\225\t\235\r\225\t\017)-9.9(\026\005\f\007 \225\235\005\024\t\004\t\004\005\200 \005\r\017\002\r\r)-10(\026\f\t\004\004\025\006)10(\025 )]TJ 0 -1 TD [(\005\004\026)11(\t\b\b\t\017)-9.9(\026)11(\016 \f\022\b\t\020\t\004\005\005 \017)10(\025\b\025\235\t\017)-9.9(\026)10.9(\016\b\206\004\025\006)10(\025 \235\016\017\016 $\025\213\220\025\235\022\b\005\026)11(\t\235\016\026)-20(\002\235\007$)]TJ 40.064 1 Td [(P)10(ossibilities and pr)20(ospects of ar)-20(tif)-20.9(icial intelligence in )]TJ 3.722 -1 Td [(th)11(e tr)31(eatment of color)31.1(ectal cancer $r)31(e)11(vie)11(w$)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0.01 Tc 0.139 Tw 10 0 0 10 42.5197 724.8299 Tm [(\023\024\035\027\024\020\024 \023\026\021\024\035\024\020\017\004\036\f\022\ \024\020\024 \024\021\r\036\021\026 \031\007\026\036\021\f\016 \023\030\017\ \n\036\030\027\024)10( )]TJ 0.117 Tw 0 -1.218 TD (\r)Tj /Span<>> BDC ( )Tj EMC (15\22627% \f\035\031\004\026\036\r [10], \023\024\220\021\024\n\031 \024\ \007\027\024\005 \017)Tj /Span<>> BDC ( )Tj EMC (\r\026\032\027\036\005)Tj 0 Tc 0 Tw (-)Tj 0.01 Tc 0.088 Tw T* [(\001\017\b \026\007\026\004 \204\210 \f\021\024\017\021 \r\024\n\024\032\ \027\024\f\021\034 \023\030\024\020\027\024\017\030\024\r\026\027\017\016\ )10( )]TJ 0.115 Tw T* (\024\021\r\036\021\026 \027\026)Tj /Span<>> BDC ( )Tj EMC (\203\202\216\214\231. \200)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\034\001\017\027\f\021\r\036 \023\031\002\035\017\022\026\006\ \017\005 \r)Tj /Span<>> BDC ( )Tj EMC 20.814 0 Td (\022\026)Tj 0 Tc 0 Tw (-)Tj 0.01 Tc 0.279 Tw -20.814 -1.218 Td (\004\036\f\021\r\036 \017\027\f\021\030\031\n\036\027\021\026 \023\030\024\ \020\027\024\017\030\024\r\026\027\017\016 \024\021\r\036\021\026 \024\023\ \031)Tj 0 Tc 0 Tw (-)Tj 0.01 Tc 0.06 Tw T* (\b\024\035\017 \027\026)Tj /Span<>> BDC ( )Tj EMC (\035\036\004\036\027\017\036 \017\f\023\024\035\034\031\036\021\f\016 \030\ \026\007\017\024\n\017\022\026 \f)Tj /Span<>> BDC ( )Tj EMC (\023\024\f\021\030\024)Tj 0 Tc 0 Tw (-)Tj 0.01 Tc 0.117 Tw 0 -1.218 TD (\036\027\017\036\n \022\035\026\f\f\017\235\017\022\026\021\024\030\026 \ \017\024\002\030\026\032\036\027\017\005 \027\026)Tj /Span<>> BDC ( )Tj EMC [(\024\f\027\024\r\026\027\017\017)10( )]TJ 0.002 Tw 0 -1.218 TD (\022\024\n\023\034\033\021\036\030\027\024\005 \021\024\n\024\020\030\026\ \235\017\017 $\025\231$ \017\035\017 \n\026\020\027\017\021\027\024-\030\ \036\024)Tj 0 Tc 0 Tw (-)Tj 0.01 Tc 0.236 Tw T* [(\027\026\027\f\027\024\005 \021\024\n\024\020\030\026\235\017\017 [13]. \ \203\036\002\024\035\034\001\024\036 \022\024\035\017\004\036\f\021\r\024\ )10( )]TJ 0.222 Tw T* (\n\024\007\036\035\036\005 \023\030\024\001\035\017 \r\026\035\017\007\026\ \006\017\033 \027\026)Tj /Span<>> BDC ( )Tj EMC [(\021\036\f\021\024\r\024\005 \r\t\002\024\030\022\036)10( )]TJ 0.135 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\n\026\022\f\017\n\026\035\034\027\024\005 \021\024\004\027\024\f\021\034\ \033 92% [14], \024\007\027\026\022\024 \r)Tj /Span<>> BDC ( )Tj EMC (\027\026)Tj 0 Tc 0 Tw (-)Tj 0.01 Tc 0.301 Tw T* [(\f\021\024\016\013\017\005 \023\036\030\017\024\007 \r\030\036\n\036\027\ \017 \023\030\024\006\036\007\031\030\031 \030\036\020\017\f\021\030\026\ \006\017\017)10( )]TJ 0.307 Tw 0 -1.218 TD (\r)Tj /Span<>> BDC ( )Tj EMC [(\022\026\004\036\f\021\r\036 \n\036\007\017\006\017\027\f\022\024\020\024\ \017\007\036\035\017\016 \027\036 \023\030\024\001\035\026 \027\017)10.1( )]TJ 0 Tw 0 -1.218 TD (\024\007\027\026 \017)Tj /Span<>> BDC ( )Tj EMC (\n\024\007\036\035\036\005.)Tj 0 Tc 0.553 Tw 0 -1.218 TD [(\200 )0.5(\022\026\004\036\f\021\r\036 )0.6(\007\030\031\020\024\020\024 )0.5(\023\030\036\007\017\022\021\024\030\026 )0.6(\024\021\r\036\021\026 )0.5(\024\023\031\b\024\035\017 )]TJ 0.092 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC (\027\036\024)Tj /Span<>> BDC ( )Tj EMC 2.777 0 Td (\026\007\255\r\026\027\021\027\024\036 \035\036\004\036\027\017\036, \024\ \021\035\017\004\027\024\020\024 \024\021 \030\026\007\017\024\n\027\t\b\ )Tj -0.011 Tw -2.777 -1.218 Td (\f\017\020\027\026\021\031\030, \n\024\020\031\021 \r\t\f\021\031\023\026\ \021\034 \b\026\030\026\022\021\036\030\017\f\021\017\022\017 \017\n\n\031\ \027\027\024\020\024 )Tj 0.096 Tw T* (\024\022\030\031\032\036\027\017\016 \024\023\031\b\024\035\017. \224\n\n\ \031\027\027\024\036 \n\017\022\030\024\024\022\030\031\032\036\027\017\036\ \016\r)Tj 0 Tw (-)Tj 0.012 Tw T* (\035\016\036\021\f\016 \024\007\027\017\n \017)Tj /Span<>> BDC ( )Tj EMC (\022\035\033\004\036\r\t\b \235\026\022\021\024\030\024\r \030\026\r\017\ \021\017\016 \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\024)Tj 0 Tw (-)Tj 0.142 Tw T* (\020\030\036\f\f\017\030\024\r\026\027\017\016 \025\217\217. \203\036\007\ \026\r\027\017\036 \027\026\004\017\021\036\035\034\027\t\036 \031\f\023\ \036\b\017 )Tj -0.078 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\017\n\n\031\027\024\021\036\030\026\023\017\017, \023\024\022\026\026\035\ \017 \023\024\021\036\027\006\017\026\035 \017\f\023\024\035\034\024\r\026\ \027\017\016 )Tj 0.166 Tw T* (\017\n\n\031\027\027\024\005 \f\017\f\021\036\n\t \007\035\016 \035\036\004\ \036\027\017\016 \025\217\217 [15], \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\n )Tj 0.118 Tw T* (\022\024\035\017\004\036\f\021\r\024, \021\017\023, \023\035\024\021\027\ \024\f\021\034 \017\027\235\017\035\034\021\030\026\006\017\017 \017)Tj /Span<>> BDC ( )Tj EMC (\035\024\022\026\035\017)Tj 0 Tw (-)Tj 0.242 Tw T* (\026\006\017\016 \017\n\n\031\027\027\t\b \022\035\036\021\024\022 \r)Tj /Span<>> BDC ( )Tj EMC (\021\022\026\027\017 \024\023\031\b\024\035\017 \024\002\035\026\007\026\ \036\021 )Tj 0.191 Tw T* (\023\030\024\020\027\024\f\021\017\004\036\f\022\017\n \023\024\021\036\027\ \006\017\026\035\024\n. \203\026)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\005 \024\f\027\024\r\036 \023\024)Tj 0 Tw (-)Tj 0.035 Tw T* [(\f\021\030\024\036\027\026 )0.5(\n\036\021\024\007\024\035\024\020\017\016 )0.6(\024\006\036\027\022\017 )0.6(\017\n\n\031\027\027\024\020\024 )0.5(\f\021\026\021\031\f\026 )0.6(\024\023\031)]TJ 0 Tw (-)Tj -0.038 Tw T* [(\b\024\035\017 $immunoscor)-24(e$ [16]. \200)]TJ /Span<>> BDC ( )Tj EMC (\017\f\f\035\036\007\024\r\026\027\017\017 \022\024\035\035\036\022\021\017\ \r\026 )Tj 0.038 Tw T* [(\026\r\021\024\030\024\r \023\024\007 \030\031\022\024\r\024\007\f\021\r\ \024\n F)10(oer)-9.9(sch \027\026)]TJ /Span<>> BDC ( )Tj EMC (\024\f\027\024\r\036 \007\026\027\027\t\b )Tj 0.244 Tw T* (1108 \023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\007\017\026\020\027\024\024\n \025\217\217 \f)Tj /Span<>> BDC ( )Tj EMC (\017\f\023\024\035\034\024\r\026\027\017)Tj 0 Tw (-)Tj 0.265 Tw T* (\036\n \f\r\036\030\021\024\004\027\024\005 \027\036\005\030\024\f\036\021\ \017 $\225\203\225$ \002\t\035\026 \030\026\030\026\002\024\021\026\027\ \026 )Tj 0.125 Tw T* (\f\017\f\021\036\n\026 \023\024\007\007\036\030\032\022\017 \023\030\017\ \027\016\021\017\016 \022\035\017\027\017\004\036\f\022\017\b \030\036\001\ \036\027\017\005 )Tj 0.538 Tw T* ($\225\215\215\025\217$, \024\f\027\024\r\026\027\027\026\016 \027\026)Tj /Span<>> BDC ( )Tj EMC (\017\n\n\031\027\024\020\017\f\021\024\023\026\021\024\035\024\020\017\004\ \036)Tj 0 Tw (-)Tj 0.213 Tw T* [(\f\022\017\b \017\024\002\030\026\032\036\027\017\016\b \030\026\035\017\ \004\027\t\b )0.5(\023\024\007\021\017\023\024\r \017\n\n\031\027\027\t\b )]TJ 0.145 Tw T* (\022\035\036\021\024\022)Tj /Span<>> BDC ( )Tj EMC [(\227 AImmunoscor)-23.9(e $AIS$ [17]. \215\024)]TJ /Span<>> BDC ( )Tj EMC (\f\024\024\002\013\036\027\017\033 )Tj 0.19 Tw T* (\026\r\021\024\030\024\r, \007\026\027\027\026\016 \n\024\007\036\035\034\ \024\002\035\026\007\026\035\026 \r\t\f\024\022\017\n \023\030\024\020\027\ \024)Tj 0 Tw (-)Tj 0.25 Tw T* [(\f\021\017\004\036\f\022\017\n )0.6(\023\024\021\036\027\006\017\026\035\024\n, )0.5(\004\021\024 )0.5(\007\026\036\021 )0.6(\r\024\n\024\032\027\024\f\021\034 )0.5(\017\f)]TJ 0 Tw (-)Tj 0.053 Tw T* (\023\024\035\034\024\r\026\027\017\016 \036\036 \007\035\016 \023\030\024\ \020\027\024\017\030\024\r\026\027\017\016 \024\021\r\036\021\026 \027\026\ )Tj /Span<>> BDC ( )Tj EMC (\027\036\024)Tj /Span<>> BDC (-)Tj EMC 0 Tw T* (\026\007\255\033\r\026\027\021\027\031\033 \021\036\030\026\023\017\033 \ [17].)Tj 0.086 Tw T* (\225\004\017\021\026\036\021\f\016, \004\021\024 \024\023\031\b\024\035\017\ \f)Tj /Span<>> BDC ( )Tj EMC (\r\t\f\024\022\024\005 \f\021\036\023\036\027\034\033 \n\031\021\026\006\ \017\017 )Tj 0.269 Tw T* (\f\024\007\036\030\032\026\021 \023\024\r\t\001\036\027\027\031\033 \027\ \026\020\030\031\022\031 \027\036\024\026\027\021\017\020\036\027\024\r\ , \004\021\024 )Tj 0.121 Tw T* (\007\036\035\026\036\021 \017\b \017\n\n\031\027\024\020\036\027\027\t\n\ \017 \017)Tj /Span<>> BDC ( )Tj EMC (\004\031\r\f\021\r\017\021\036\035\034\027\t\n\017 \022)Tj /Span<>> BDC ( )Tj EMC (\017\n)Tj 0 Tw (-)Tj -0.051 Tw T* [(\n\031\027\024\021\036\030\026\023\017\017 )0.6([18]. )0.5(\204\017\022\030\024\f\026\021\036\035\035\017\021\027\026\016 )0.6(\027\036\f\021\026\002\017\035\034\027\024\f\021\034 )]TJ 0.006 Tw T* ($\204\225\203$ \024\002\027\026\030\031\032\017\r\026\036\021\f\016 \023\ \030\017\n\036\030\027\024 \r)Tj /Span<>> BDC ( )Tj EMC (15% \025\217\217 [19], \024\007)Tj 0 Tw (-)Tj -0.035 Tw T* (\027\026\022\024 \027\026)Tj /Span<>> BDC ( )Tj EMC (\f\036\020\024\007\027\016 \024\021\f\031\021\f\021\r\031\033\021 \017\f\ \f\035\036\007\024\r\026\027\017\016, \r)Tj /Span<>> BDC ( )Tj EMC (\022\024\021\024\030\t\b )Tj -0.002 Tw T* (\220\021\024\021 \023\024\022\026\026\021\036\035\034 \017\f\023\024\035\ \034\024\r\026\035\f\016 \002\t \r)Tj /Span<>> BDC ( )Tj EMC (\022\026\004\036\f\021\r\036 \030\036\031\035\034)Tj 0 Tw (-)Tj 0.17 Tw T* (\021\026\021\026 \023\030\036\007\f\022\026\026\027\017\016 \n\024\007\036\ \035\036\005 \204\210. \225\f\t\035\026\016\f\034 \027\026)Tj /Span<>> BDC ( )Tj EMC (\024\021\f\031\021)Tj 0 Tw (-)Tj 0.165 Tw T* [(\f\021\r\017\036 )0.5(\031\027\017\r\036\030\f\026\035\034\027\024\f\021\017, )0.6(\r\t\f\024\022\024\005 )0.5(\f\021\024\017\n\024\f\021\017 )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC 19.791 0 Td (\027\026\035\017)Tj 0 Tw (-)Tj 0.026 Tw -19.791 -1.218 Td (\004\017\036 \021\036\b\027\017\004\036\f\022\017\b \024\020\030\026\027\ \017\004\036\027\017\005, \026\r\021\024\030\t \027\036 \017\f\023\024\035\ \034\031\033\021 )Tj 0.1 Tw T* (\204\225\203 \022\026\022 \024\021\007\036\035\034\027\t\005 \235\026\022\ \021\024\030, \026)Tj /Span<>> BDC ( )Tj EMC (\023\t\021\026\033\021\f\016 \023\030\036\007\f\022\026\026\021\034 )Tj 0.023 Tw T* (\036\036 \f)Tj /Span<>> BDC ( )Tj EMC (\023\024\n\024\013\034\033 \030\026\035\017\004\027\t\b \n\024\007\036\035\ \036\005 \204\210 \023\024)Tj /Span<>> BDC ( )Tj EMC (\r\017\031\026\035\034\027\t\n )Tj 0.117 Tw T* (\024\002\030\026\026\n \204\217\231 [20]. \215\024\007\024\002\027\t\n \ \024\002\030\026\024\n, \r)Tj /Span<>> BDC ( )Tj EMC (\027\026\f\021\024\016\013\017\005 )Tj 0.001 Tw T* (\023\036\030\017\024\007 \r\030\036\n\036\027\017, \007\036\035\024 \024\ \002\f\021\024\017\021 \017)Tj /Span<>> BDC ( )Tj EMC [(\f \007\036\021\036\022\006\017\036\005 )0.5(\n\031\021\026\006\017\005 )]TJ /T1_2 1 Tf 0 Tw T* [(KRA)50(S)]TJ /T1_1 1 Tf -0.032 Tw (, \020\007\036 \r)Tj /Span<>> BDC ( )Tj EMC (\022\026\004\036\f\021\r\036 \017\027\f\021\030\031\n\036\027\021\026 \021\ \026\022\032\036 \017\f\023\024\035\034\031\033\021\f\016 )Tj 0 Tw T* (\030\026\007\017\024\n\027\t\036 \n\024\007\036\035\017 \204\210 [21\226\ 23].)Tj 0.337 Tw 23.244 64.543 Td [(\224\r\036\f\021\027\024, \004\021\024 \026\002\f\024\035\033\021\027\024\ \036 )0.5(\031\035\031\004\001\036\027\017\036 \r\t\032\017\r\026\036\n\024)]TJ 0 Tw (-)Tj 0.027 Tw T* (\f\021\017, \r\t\r\026\027\027\024\036 \026\007\255\033\r\026\027\021\027\ \024\005 \216\231, \024\006\036\027\017\r\026\036\021\f\016 \r)Tj /Span<>> BDC ( )Tj EMC (2\2265% )Tj 0.055 Tw T* (\023\030\017)Tj /Span<>> BDC ( )Tj EMC (II \f\021\026\007\017\017 \017)Tj /Span<>> BDC ( )Tj EMC (10\22622%)Tj /Span<>> BDC ( )Tj EMC (\227 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (III \f\021\026\007\017\017 \025\217\217, \017)Tj /Span<>> BDC ( )Tj EMC (\220\021\026 )Tj 0.244 Tw T* (\f\031\013\036\f\021\r\036\027\027\026\016 \030\026\027\017\006\026 \r)Tj /Span<>> BDC ( )Tj EMC (\031\035\031\004\001\036\027\017\017 \r\t\032\017\r\026\036\n\024\f\021\017\ )Tj -0.046 Tw T* (\n\024\032\036\021 \002\t\021\034 \024\002\255\016\f\027\036\027\026, \023\ \030\036\032\007\036 \r\f\036\020\024, \027\026\004\017\n\t\n\017 \030\026\ )Tj 0 Tw (-)Tj 0.084 Tw T* [(\035\017\004\017\016\n\017 )0.5(\030\017\f\022\026 \035\036\021\026\035\034\027\024\f\021\017 )0.6(\023\030\017)]TJ /Span<>> BDC ( )Tj EMC [(II )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC [(III )0.5(\f\021\026\007\017\017 \030\026\022\026 )]TJ -0.01 Tw 0 -1.218 TD (\021\024\035\f\021\024\005 \022\017\001\022\017 [24]. \215\024\220\021\024\ \n\031 \r)Tj /Span<>> BDC ( )Tj EMC (\017\f\f\035\036\007\024\r\026\027\017\017 \022\024\035\035\036\022)Tj 0 Tw (-)Tj 0.181 Tw 0 -1.218 TD (\021\017\r\026 \017)Tj /Span<>> BDC ( )Tj EMC (\203\024\030\r\036\020\017\017 \023\024\007 \030\031\022\024\r\024\007\f\ \021\r\024\n Kleppe \026\r\021\024\030\t )Tj 0.037 Tw T* (\023\024\023\t\021\026\035\017\f\034 \f)Tj /Span<>> BDC ( )Tj EMC [(\023\024\n\024\013\034\033 \225\203\225 \f\021\030\026\021\017\235\017\006\ \017\030\024\r\026\021\034 )0.5(\030\017\f\022\017 )]TJ -0.025 Tw T* (\017, \017\f\b\024\007\016 \017)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\020\024, \024\023\021\017\n\017\017\030\024\r\026\021\034 \ \027\026\027\026\004\036\027\017\036 \026\007\255\033)Tj 0 Tw (-)Tj 0.042 Tw T* (\r\026\027\021\027\024\005 \216\231 \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (II \017)Tj /Span<>> BDC ( )Tj EMC (III \f\021\026\007\017\016\n\017 \025\217\217 [25]. )Tj 0.079 Tw T* (\200)Tj /Span<>> BDC ( )Tj EMC 0.857 0 Td [(\024\f\027\024\r\031 )0.5(\017\f\f\035\036\007\024\r\026\027\017\016 )0.6(\035\036\020\035\024 )0.5(\017\f\023\024\035\034\024\r\026\027\017\036 )0.6(\027\024\r\024\020\024 )]TJ 0.066 Tw -0.857 -1.218 Td [(\n\026\030\022\036\030\026 DoM)-24(or)-24(e-v1-CRC, \023\024\035\031\004\036\027\027\024\020\024 \f)]TJ /Span<>> BDC ( )Tj EMC (\023\024\n\024\013\034\033 \026\r)Tj 0 Tw (-)Tj 0.318 Tw 0 -1.218 TD (\021\024\n\026\021\017\017\030\024\r\026\027\027\024\020\024 \026\027\026\ \035\017\026 \024\021\f\022\026\027\017\030\024\r\026\027\027\t\b \f\030\ \036)Tj 0 Tw (-)Tj 0.137 Tw 0 -1.218 TD (\024\r \024\023\031\b\024\035\036\r\024\005 \021\022\026\027\017, \024\022\ \030\026\001\036\027\027\t\b \020\036\n\026\021\024\022\f\017\035\017\027\ \024\n )Tj 0.108 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\220\024\017\027\024\n, \022\024\021\024\030\t\005 \002\t\035 \024\023\017\ \f\026\027 \023\024\007\030\024\002\027\024 \026\r\021\024\030\026\n\017\ )Tj 0.302 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\017\b \023\030\036\007\t\007\031\013\036\n \017\f\f\035\036\007\024\r\026\ \027\017\017 [26]. \215\024\035\031\004\036\027\027\026\016 )Tj 0.412 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\030\036\031\035\034\021\026\021\036 \n\024\007\036\035\034 \f\021\030\026\ \021\017\235\017\006\017\030\031\036\021 \030\017\f\022 \002\024\035\036\ \036 )Tj 0.214 Tw T* (\021\024\004\027\024, \004\036\n \036\036 \f\024\f\021\026\r\035\016\033\ \013\017\036 \220\035\036\n\036\027\021\t, \017)Tj /Span<>> BDC ( )Tj EMC (\r\t\016\r\035\016\036\021 )Tj 0.061 Tw T* (\027\026\004\017\021\036\035\034\027\024 \002\024\035\034\001\036 \023\026\ \006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\025\217\217 II \017)Tj /Span<>> BDC ( )Tj EMC (III \f\021\026\007\017\005 )Tj -0.004 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\017\n \032\036 \b\024\030\024\001\017\n \023\030\024\020\027\ \024\024\n, \022\026\022 \031)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\t \027\017\022\024\020\024 )Tj 0.174 Tw T* (\030\017\f\022\026 \r)Tj /Span<>> BDC ( )Tj EMC [(\021\036\022\031\013\017\b \030\036\022\024\n\036\027\007\026\006\017\016\ \b )0.5([25]. )0.5(\200\t\r\024\007, \022\024\021\024)]TJ 0 Tw (-)Tj 0.121 Tw T* (\030\t\005 \023\030\017\r\024\007\017\021\f\016 \r)Tj /Span<>> BDC ( )Tj EMC (\017\f\f\035\036\007\024\r\026\027\017\017, \020\024\r\024\030\017\021 \024\ )Tj /Span<>> BDC ( )Tj EMC (\021\024\n, \004\021\024 )Tj 0.164 Tw T* (\024\021\022\026 \024\021 \026\007\255\033\r\026\027\021\027\024\005 \216\ \231 \031)Tj /Span<>> BDC ( )Tj EMC (\r\t\016\r\035\036\027\027\t\b \f)Tj /Span<>> BDC ( )Tj EMC (\023\024\n\024\013\034\033 )Tj 0.072 Tw T* (\026\035\020\024\030\017\021\n\026 \020\030\031\023\023 \023\026\006\017\ \036\027\021\024\r \n\024\032\036\021 \002\t\021\034 \002\036\024\023\026\ \f\027\t\n, )Tj 0.333 Tw T* (\021\026\022\017\n \024\002\030\026\024\n, \r)Tj /Span<>> BDC ( )Tj EMC (\002\031\007\031\013\036\n \023\024\016\r\017\021\f\016 \r\024\n\024\032\ \027\024\f\021\034 )Tj -0.011 Tw T* (\f\027\017\032\036\027\017\016 \004\026\f\021\024\021\t \016\r\035\036\027\ \017\005 \021\024\022\f\017\004\027\024\f\021\017 \b\017\n\017\024\023\030\ \036\023\026)Tj 0 Tw (-)Tj 0.063 Tw T* (\030\026\021\024\r, \f\n\036\030\021\027\024\f\021\017, \026\f\f\024\006\ \017\017\030\024\r\026\027\027\024\005 \f)Tj /Span<>> BDC ( )Tj EMC (\021\024\022\f\017\004\036\f\022\017\n\017 )Tj 0.079 Tw T* (\220\235\235\036\022\021\026\n\017 \b\017\n\017\024\021\036\030\026\023\017\ \017, \017)Tj /Span<>> BDC ( )Tj EMC (\026\021\030\026\021 \027\026)Tj /Span<>> BDC ( )Tj EMC (\035\036\004\036\027\017\036 [25]. )Tj 0.121 Tw T* (\215\024\f\035\036\007\027\017\036 \007\r\026 \031\023\024\n\016\027\031\ \021\t\b \r\t\001\036 \026\035\020\024\030\017\021\n\026 \n\026\001\017\027\ )Tj 0 Tw (-)Tj T* (\027\024\020\024 \024\002\031\004\036\027\017\016 \023\030\024\001\035\017\ \r\027\036\001\027\033\033 \r\026\035\017\007\026\006\017\033 [25,26].)Tj 0.321 Tw T* [(\206\024\r\024\030\016 )0.5(\024)]TJ /Span<>> BDC ( )Tj EMC 4.49 0 Td [(\f\017\f\021\036\n\026\b )0.5(\023\024\007\007\036\030\032\022\017 )0.5(\023\030\017\027\016\021\017\016 )0.6(\022\035\017\027\017\004\036)]TJ 0 Tw (-)Tj 0.059 Tw -4.49 -1.218 Td (\f\022\017\b \030\036\001\036\027\017\005 $\225\215\215\025\217$, \027\ \036\035\034\016 \027\036 \031\023\024\n\016\027\031\021\034 IBM $R$ \ )Tj 0.035 Tw T* [(W)12(a)15(tson for Oncol)30(o)-16(g)16(y $WfO$. \215\024\f\035\036\007\027\016\016 \023\030\036\007\024\f\021\ \026\r\035\016\036\021 )]TJ -0.001 Tw T* (\024\027\022\024\035\024\020\026\n \024\f\027\024\r\026\027\027\t\036 \027\ \026)Tj /Span<>> BDC ( )Tj EMC (\235\026\022\021\017\004\036\f\022\017\b \007\026\027\027\t\b \r\026\030\ \017)Tj 0 Tw (-)Tj 0.206 Tw T* (\026\027\021\t \021\036\030\026\023\017\017. \215\024)Tj /Span<>> BDC ( )Tj EMC (\007\026\027\027\t\n \017\f\f\035\036\007\024\r\026\021\036\035\036\005,\ \f\017\f\021\036\n\026 )Tj 0.121 Tw T* (WfO \r)Tj /Span<>> BDC ( )Tj EMC 2.756 0 Td [(70% \f\035\031\004\026\036\r \023\030\036\007\f\021\026\r\035\016\035\026\ )0.5(\r\026\030\017\026\027\021 )0.5(\f\021\030\026\021\036\020\017\017 )]TJ 0.208 Tw -2.756 -1.218 Td (\035\036\004\036\027\017\016, \f\024\023\024\f\021\026\r\017\n\t\005 \017\ \035\017 \026\027\026\035\024\020\017\004\027\t\005 \r\026\030\017\026\027\ \021\031, )Tj 0 Tw T* (\023\030\036\007\035\024\032\036\027\027\024\n\031 \r\030\026\004\026\n\017\ -\024\027\022\024\035\024\020\026\n\017 [27].)Tj -0.015 Tw T* (\212\035\017\027\027\t\036 \027\036\022\024\007\017\030\031\033\013\017\036\ \217\203\025 $\027\022\217\203\025$ \f\036\005\004\026\f \030\026\f\f\ \n\026)Tj 0 Tw (-)Tj 0.064 Tw T* (\021\030\017\r\026\033\021\f\016 \022\026\022 \023\024\021\036\027\006\017\ \026\035\034\027\t\036 \002\017\024\n\026\030\022\036\030\t \023\030\024\ \020\027\024\026 )Tj -0.054 Tw T* (\025\217\217 [28]. \210\002\027\026\030\031\032\036\027\024, \004\021\024\ \027\022\217\203\025 \f\r\016\026\027\t \f)Tj /Span<>> BDC ( )Tj EMC (\017\n\n\031\027\027\t)Tj 0 Tw (-)Tj 0.039 Tw T* (\n\017 \n\024\007\017\235\017\022\026\006\017\016\n\017 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\025\217\217, \017)Tj /Span<>> BDC ( )Tj EMC (\007\026\027\027\t\005 \023\026\030\026\n\036\021\030 \031\032\036 )Tj 0.126 Tw T* (\017\f\023\024\035\034\031\036\021\f\016 \007\035\016 \023\030\024\020\027\ \024\017\030\024\r\026\027\017\016 \024\021\r\036\021\026 \027\026)Tj /Span<>> BDC ( )Tj EMC (\026\007\255\033)Tj 0 Tw (-)Tj 0.02 Tw T* (\r\026\027\021\027\031\033 \b\017\n\017\024\021\036\030\026\023\017\033 \ \027\026)Tj /Span<>> BDC ( )Tj EMC (\024\f\027\024\r\036 \235\021\024\030\031\030\026\006\017\035\026 \f)Tj /Span<>> BDC ( )Tj EMC (\023\024)Tj 0 Tw (-)Tj 0.13 Tw T* (\n\024\013\034\033 \n\024\007\036\035\017 \204\210, \023\024\035\031\004\ \017\r\001\036\005 \027\026\r\026\027\017\036 consensus )Tj 0.057 Tw T* [(immune-r)-23.9(el)-16(a)15(ted lncRN)13(A signa)15(tur)-24(e $\f\017\020\027\026\021\031\030\026 \024\023\031\b\024\035\017 )]TJ 0.07 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC (\024\f\027\024\r\036 \023\030\024\235\017\035\016 \220\022\f\023\030\036\ \f\f\017\017 \027\022\217\203\025$ [29]. \212\026\027\027\026\016 )Tj 0.169 Tw T* (\n\024\007\036\035\034 \n\024\032\036\021 \017\007\036\027\021\017\235\017\ \006\017\030\024\r\026\021\034 \023\026\006\017\036\027\021\024\r, \027\036\ \024\021)Tj 0 Tw (-)Tj 0.058 Tw T* [(\r\036\004\026\033\013\017\b )0.6(\027\026)]TJ /Span<>> BDC ( )Tj EMC 5.743 0 Td [(\026\007\255\033\r\026\027\021\027\031\033 )0.6(\b\017\n\017\024\021\036\030\026\023\017\033 )0.6(\027\026)]TJ /Span<>> BDC ( )Tj EMC 13.478 0 Td (\024\f\027\024\r\036 )Tj 0.132 Tw -19.221 -1.218 Td (\235\021\024\030\031\030\026\006\017\035\026 \f)Tj /Span<>> BDC ( )Tj EMC (\021\024\004\027\024\f\021\034\033 85% [29]. \224\f\023\024\035\034\024\ \r\026\027\017\036 )Tj 0.039 Tw T* (\020\036\027\036\021\017\004\036\f\022\017\b \f\017\020\027\026\021\031\030\ \022\026\022 \017\f\b\024\007\027\t\b \023\026\030\026\n\036\021\030\024\ \r \007\035\016 )Tj 0.356 Tw T* [(\023\030\024\020\027\024\027\t\b \n\024\007\036\035\036\005 )0.5(\016\r\035\016\036\021\f\016 \023\036\030\f\023\036\022\021\017\r\027\t\n\ \027\026)]TJ 0 Tw (-)Tj 0.485 Tw T* [(\023\030\026\r\035\036\027\017\036\n, )0.6(\036\007\017\027\f\021\r\036\027\027\t\n )0.5(\024\020\030\026\027\017\004\036\027\017\036\n )0.6(\007\026\027\027\024\005 )]TJ 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 0 Tw 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\205)10(\210\036\033 \035\030\032\204\033)30(\021)42(\032)-21(\211\033\237)]TJ 57.136 0 Td (REVIEW)Tj /T1_3 1 Tf 25 0 0 25 505.577 56.0378 Tm (187)Tj ET endstream endobj 276 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.04 Tw 10 0 0 10 70.8661 724.8299 Tm (\f\021\036\023\036\027\017 \024\002\013\017\005 \021\036\030\n\017\027, \ \r)Tj /Span<>> BDC ( )Tj EMC (\021\024 \r\030\036\n\016 \022\026\022 \n\026\001\017\027\027\024\036 \024\ \002)Tj 0 Tw (-)Tj 0.023 Tw 0 -1.218 TD (\031\004\036\027\017\036 $\204\210$ \017)Tj /Span<>> BDC ( )Tj EMC (\020\035\031\002\024\022\024\036 \024\002\031\004\036\027\017\036 $\206\ \210$ \016\r\035\016\033\021\f\016 \007\r\031)Tj 0 Tw (-)Tj -0.012 Tw T* [(\n\016 )0.5(\027\026\017\002\024\035\036\036 \001\017\030\024\022\024 )0.5(\017\f\023\024\035\034\031\036\n\t\n\017 )0.5(\023\024\007\b\024\007\026\n\017 \022)]TJ /Span<>> BDC ( )Tj EMC (\224\224 )Tj 0 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\n\036\007\017\006\017\027\036.)Tj 0.14 Tw T* (\225\031\013\036\f\021\r\031\036\021 \027\036\f\022\024\035\034\022\024 \ \026\035\020\024\030\017\021\n\024\r \204\210, \027\026\017\002\024\035\036\ \036 \004\026)Tj 0 Tw (-)Tj 0.037 Tw T* (\f\021\024 \017\f\023\024\035\034\031\036\n\t\b \r)Tj /Span<>> BDC ( )Tj EMC (\017\f\f\035\036\007\024\r\026\027\017\016\b \025\217\217: \n\036\021\024\ \007 \024\023\024\030)Tj 0 Tw (-)Tj 0.065 Tw 0 -1.218 TD (\027\t\b \r\036\022\021\024\030\024\r $\204\210\200$ \023\024\r\024\035\ \016\036\021 \r\t\023\024\035\027\016\021\034 \f\021\030\026\021\017\235\ \017)Tj 0 Tw (-)Tj 0.271 Tw 0 -1.218 TD (\022\026\006\017\033 \026\002\024\035\036\r\026\027\017\005 \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\020\027\024\017\030\024\r\026\027\017\036 \027\026)Tj /Span<>> BDC ( )Tj EMC (\024\f\027\024\r\036 )Tj 0.147 Tw T* (\030\036\020\030\036\f\f\017\017 \017)Tj /Span<>> BDC ( )Tj EMC (\022\035\026\f\f\017\235\017\022\026\006\017\017 [5], \020\035\031\002\024\ \022\024\036 \024\002\031\004\036\027\017\036 )Tj 0.073 Tw T* (\017\f\023\024\035\034\031\036\021 \n\036\021\024\007\t \204\210, \027\026\ \t\r\026\036\n\t\036 \017\f\022\031\f\f\021\r\036\027\027\t\n\017 )Tj 0.229 Tw T* (\027\036\005\030\024\027\027\t\n\017 \f\036\021\016\n\017, \007\035\016 \ \017\r\035\036\004\036\027\017\016 \026\022\024\027\024\n\036\030\027\024\ )Tj 0 Tw (-)Tj 0.17 Tw T* (\f\021\036\005 \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\f\021\026\r\035\036\027\017\016 \023\030\024\020\027\024\024\r \017\ )Tj /Span<>> BDC ( )Tj EMC (\002\024\035\034\001\017\b \027\026\002\024\030\024\r )Tj 0.088 Tw 0 -1.218 TD (\007\026\027\027\t\b [6], \f\r\036\030\021\024\004\027\t\036 \027\036\005\ \030\024\027\027\t\036 \f\036\021\017 $\225\203\225$ \017\020\030\026)Tj 0 Tw (-)Tj 0.085 Tw 0 -1.218 TD [(\033\021 )0.5(\r\026\032\027\031\033 \030\024\035\034 \r)]TJ /Span<>> BDC ( )Tj EMC 7.942 0 Td [(\030\026\f\023\024\027\026\r\026\027\017\017 \n\036\007\017\006\017\027\ \f\022\017\b )0.5(\017\024)]TJ 0 Tw (-)Tj -0.021 Tw -7.942 -1.218 Td (\002\030\026\032\036\027\017\005, \022\035\026\f\f\017\235\017\022\026\006\ \017\017 \024\002\255\036\022\021\024\r \017)Tj /Span<>> BDC ( )Tj EMC (\f\036\n\026\027\021\017\004\036\f\022\024\005 )Tj -0.036 Tw 0 -1.218 TD (\f\036\020\n\036\027\021\026\006\017\017 [7]. \200)Tj /Span<>> BDC ( )Tj EMC (\007\026\027\027\024\n \024\002\024\030\036 \027\036 \024\f\r\036\013\036\ \027\t \023\030\024\002)Tj 0 Tw (-)Tj 0.082 Tw T* (\035\036\n\t \030\026\007\017\024\n\017\022\017 \017)Tj /Span<>> BDC ( )Tj EMC (\017\f\023\024\035\034\024\r\026\027\017\016 \204\210 \r)Tj /Span<>> BDC ( )Tj EMC (\030\026\f\023\024\027\026\r\026)Tj 0 Tw (-)Tj 0.051 Tw T* (\027\017\017 \n\036\007\017\006\017\027\f\022\017\b \017\024\002\030\026\ \032\036\027\017\005, \021\026\022 \022\026\022 \r)Tj /Span<>> BDC ( )Tj EMC (\027\026\f\021\024\016\013\017\005 )Tj 0.008 Tw T* (\n\024\n\036\027\021 \007\026\027\027\026\016 \024\002\035\026\f\021\034\ \023\030\017\n\036\027\036\027\017\016 \224\224 \035\036\032\017\021 \r\ )Tj /Span<>> BDC ( )Tj EMC (\017\027\024\005 )Tj 0.114 Tw T* (\023\035\024\f\022\024\f\021\017, \027\036 \026\021\030\026\020\017\r\026\ \033\013\036\005 \r\024\023\030\024\f\024\r \r\036\007\036\027\017\016 \023\ \026)Tj 0 Tw (-)Tj 0.003 Tw T* (\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\031\f\021\026\027\024\r\035\036\027\027\t\n \007\017\026\020\027\024\024\ \n \025\217\217 [8]. \200)Tj /Span<>> BDC ( )Tj EMC (\024\002\024)Tj 0 Tw (-)Tj -0.007 Tw T* (\030\036 \024\002\f\031\032\007\026\036\021\f\016 \023\030\017\n\036\027\ \036\027\017\036 \204\210 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\035\036\004\036\027\017\017 \023\026\006\017\036\027)Tj 0 Tw (-)Tj 0.039 Tw T* (\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\025\217\217 \f)Tj /Span<>> BDC ( )Tj EMC (\021\024\004\022\017 \030\036\027\017\016 \021\036\030\026\023\036\r\021\ \017\004\036\f\022\017\b \f\021\030\026\021\036\020\017\005, )Tj 0.035 Tw T* (\024\006\036\027\022\017 \r\036\030\024\016\021\027\024\f\021\017 \030\026\ \035\017\004\027\t\b \b\017\030\031\030\020\017\004\036\f\022\017\b \f\024\ \002\t)Tj 0 Tw (-)Tj T* (\021\017\005 \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\020\027\024\026 \026\002\024\035\036\r\026\027\017\016.)Tj 0.043 Tw T* (\200 \022\026\032\007\024\005 \017)Tj /Span<>> BDC ( )Tj EMC (\n\024\007\036\035\036\005 \204\210, \024\023\017\f\026\027\027\t\b \027\ \017\032\036, \002\031\007\031\021 \017\f)Tj 0 Tw (-)Tj 0.197 Tw T* (\023\024\035\034\024\r\026\027\t \030\026\035\017\004\027\t\036 \n\036\ \021\030\017\022\017 \021\024\004\027\024\f\021\017 $\004\031\r\f\021\r\ \017)Tj 0 Tw (-)Tj 0.355 Tw T* (\021\036\035\034\027\024\f\021\034, \f\023\036\006\017\235\017\004\027\024\ \f\021\034, \021\024\004\027\024\f\021\034$, \026)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\032\036 \023\024)Tj 0 Tw (-)Tj 0.1 Tw T* [(\022\026\026\021\036\035\034 A)17(UC $Ar)-24(ea U)13(nder)-22(t)-13(he Cur)-32(ve$)]TJ /Span<>> BDC ( )Tj EMC (\227 \023\035\024\013\026\007\034 \023\024\007 )Tj 0.297 Tw T* [(ROC-\022\030\017\r\024\005. A)17(UC)]TJ /Span<>> BDC ( )Tj EMC (\227 \023\024\022\026\026\021\036\035\034, \b\026\030\026\022\021\036\030\ \017\031\033\013\017\005 )Tj -0.016 Tw T* (\026\r\017\f\017\n\024\f\021\034 TPR $\007\024\035\016 \017\f\021\017\027\ \027\024 \023\024\035\024\032\017\021\036\035\034\027\t\b \022\035\026\f\ )Tj 0 Tw (-)Tj -0.001 Tw T* (\f\017\235\017\022\026\006\017\005$ \024\021 FPR $\007\024\035\016 \035\ \024\032\027\024\023\024\035\024\032\017\021\036\035\034\027\t\b \022\035\ \026\f)Tj 0 Tw (-)Tj 0.28 Tw T* (\f\017\235\017\022\026\006\017\005$. \200)Tj /Span<>> BDC ( )Tj EMC (\f\035\031\004\026\036 \017\007\036\026\035\034\027\024\020\024 \022\035\ \026\f\f\017\235\017\022\026\021\024\030\026 )Tj -0.048 Tw T* [(A)17(UC)]TJ /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (1, \r)Tj /Span<>> BDC ( )Tj EMC (\f\035\031\004\026\036 \022\035\026\f\f\017\235\017\022\026\021\024\030\026\ , \017\f\023\024\035\034\031\033\013\036\020\024 \007\035\016 )Tj 0 Tw T* [(\023\030\036\007\f\022\026\026\027\017\016 \020\036\027\036\030\026\021\ \024\030 \f\035\031\004\026\005\027\t\b \004\017\f\036\035, A)17.3(UC)]TJ /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0.5.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0.01 Tc 0.018 Tw 14 0 0 14 70.936 274.2438 Tm [(\017\034\r\241)5( \031\032\032\r\034\226\037\023\026\022\031\025)]TJ 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0 Tc 0.052 Tw 10 0 0 10 70.8661 249.8878 Tm (\224\031\004\036\027\017\036 \f\024\r\030\036\n\036\027\027\t\b \023\024\ \007\b\024\007\024\r \022)Tj /Span<>> BDC ( )Tj EMC (\023\030\017\n\036\027\036\027\017\033 \021\036\b)Tj 0 Tw (-)Tj 0.142 Tw T* (\027\024\035\024\020\017\005 \n\026\001\017\027\027\024\020\024 \024\002\ \031\004\036\027\017\016 $\204\210$ \017)Tj /Span<>> BDC ( )Tj EMC (\020\035\031\002\024\022\024\020\024 \024\002)Tj 0 Tw (-)Tj 0.092 Tw T* (\031\004\036\027\017\016 \027\026)Tj /Span<>> BDC ( )Tj EMC (\030\026\035\017\004\027\t\b \220\021\026\023\026\b \r\036\007\036\027\017\ \016 \002\024\035\034\027\t\b \022\024\035\024)Tj 0 Tw (-)Tj T* (\030\036\022\021\026\035\034\027\t\n \030\026\022\024\n.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0.01 Tc 0.018 Tw 14 0 0 14 70.936 176.8198 Tm [(\240)21(\026)45(\024\034\033\031\026)-10(\r\232)5( \031)5(\016)-18.3(\240\034)-31(\024)35(\037\226\232)]TJ 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0 Tc 0.424 Tw 10 0 0 10 70.8661 152.4638 Tm (\215\030\017 \026\027\026\035\017\036 \024\023\031\002\035\017\022\024\r\ \026\027\027\t\b \007\026\027\027\t\b \r)Tj /Span<>> BDC ( )Tj EMC [(Na)15(t)-32(ional )]TJ 0.3 Tw T* [(L)-32(ibr)-33(ar)-23.9(y )0.5(of )0.5(Medic)-24(ine )0.6($\002\026\026 )0.5(\007\026\027\027\t\b )0.5(P)20(ubmed$ )0.6(\026)]TJ /Span<>> BDC ( )Tj EMC 20.757 0 Td (\023\024)Tj 0 Tw (-)Tj 0.133 Tw -20.757 -1.218 Td (\f\035\036\007\027\017\036 5)Tj /Span<>> BDC ( )Tj EMC (\035\036\021 \002\t\035\026 \023\030\024\017\r\036\007\036\027\026 \024\ \006\036\027\022\026 \220\235\235\036\022\021\017\r)Tj 0 Tw (-)Tj 0.344 Tw T* (\027\024\f\021\017 \030\026\035\017\004\027\t\b \023\024\007\b\024\007\024\ \r \022)Tj /Span<>> BDC ( )Tj EMC (\017\f\023\024\035\034\024\r\026\027\017\033 \021\036\b)Tj 0 Tw (-)Tj 0.241 Tw T* [(\027\024\035\024\020\017\005 \017\f\022\031\f\f\021\r\036\027\027\024\020\ \024 )0.5(\017\027\021\036\035\035\036\022\021\026 \r)]TJ /Span<>> BDC ( )Tj EMC (\007\017\026\020\027\024\f\021\017\022\036, )Tj 0.256 Tw T* (\035\036\004\036\027\017\017 \022\024\035\024\030\036\022\021\026\035\034\ \027\024\020\024 \030\026\022\026 \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\020\027\024\017\030\024\r\026\027\017\017 )Tj 0.352 Tw T* (\017\f\b\024\007\024\r. \215\024\017\f\022 \023\030\024\r\024\007\017\035\ \f\016 \023\024)Tj /Span<>> BDC ( )Tj EMC (\022\035\033\004\036\r\t\n \f\035\024\r\026\n )Tj 0.234 Tw 23.244 64.543 Td [(\236col)30(or)-24(ec)-15.9(t)15(al cancer\237, )0.6(\236ar)-22(t)-32(i\243c)-24(ial )0.5(intell)-30.9(igence )0.5(for )0.5(r)-24(ec)-16(t)15(al )]TJ -0.008 Tw 0 -1.218 TD [(cancer\237, \236ma)-17(chine lear)-15(ning in col)30(or)-24(ec)-15.9(t)15(al cancer\237, \236deep )]TJ 0.217 Tw 0 -1.218 TD [(lear)-15(ning in col)30(or)-23.9(ec)-16(t)15(al cancer\237, \236genomic r)-24(esear)-31.9(ch in )]TJ 0.412 Tw 0 -1.218 TD [(col)30(or)-24(ec)-16(t)15.1(al cancer\237. \200)]TJ /Span<>> BDC ( )Tj EMC (\b\024\007\036 \023\036\030\r\017\004\027\024\020\024 \f\022\030\017\027\ \017\027\020\026 )Tj 0.125 Tw T* [(\002\t\035\017 \023\030\024\026\027\026\035\017\017\030\024\r\026\027\t\ )0.5(\026\002\f\021\030\026\022\021\t 398)]TJ /Span<>> BDC ( )Tj EMC (\023\031\002\035\017\022\026\006\017\005 )Tj 0.01 Tw T* (2018\2262023)Tj /Span<>> BDC ( )Tj EMC (\020\020., \017\f\022\035\033\004\036\027\t \023\031\002\035\017\022\026\ \006\017\017, \023\024\f\r\016\013\036\027\027\t\036 )Tj 0.167 Tw 0 -1.218 TD (\023\030\024\002\035\036\n\026\n \030\026\f\023\024\027\026\r\026\027\017\ \016 \f\017\020\027\026\021\031\030 \022\024\035\024\030\036\022\021\026\ \035\034\027\024)Tj 0 Tw (-)Tj 0.212 Tw 0 -1.218 TD (\020\024 \030\026\022\026 \027\026)Tj /Span<>> BDC ( )Tj EMC (\022\024\n\023\034\033\021\036\030\027\t\b \017)Tj /Span<>> BDC ( )Tj EMC (\n\026\020\027\017\021\027\024-\030\036\024\027\026\027\f\027\t\b )Tj 0.315 Tw T* [(\021\024\n\024\020\030\026\n\n\026\b. )0.6(\224\031\004\036\027\t )0.5(\021\036\022\f\021\t )0.6(274)]TJ /Span<>> BDC ( )Tj EMC 15.624 0 Td [(\030\036\033\n\036 )0.6(\f\021\026\021\036\005, )]TJ 0.427 Tw -15.624 -1.218 Td (\017\f\022\035\033\004\036\027\t 162)Tj /Span<>> BDC ( )Tj EMC (\030\026\002\024\021\t, \023\024\f\r\016\013\036\027\027\t\036 \023\030\024\ \002\035\036\n\026\n )Tj 0.049 Tw T* (\024\023\021\017\n\017\026\006\017\017 \n\026\021\036\n\026\021\017\004\ \036\f\022\017\b \n\036\021\024\007\024\r \007\035\016 \224\224, \026)Tj /Span<>> BDC ( )Tj EMC (\021\026\022)Tj 0 Tw (-)Tj 0.111 Tw T* [(\032\036 )0.5(\030\026\002\024\021\t \002\036 )0.5(\007\024\f\021\031\023\026 \022)]TJ /Span<>> BDC ( )Tj EMC 10.892 0 Td [(\023\024\035\027\t\n )0.5(\021\036\022\f\021\026\n, \017)]TJ /Span<>> BDC ( )Tj EMC 8.067 0 Td (\030\026\002\024\021\t, )Tj 0.293 Tw -18.958 -1.218 Td (\r)Tj /Span<>> BDC ( )Tj EMC (\022\024\021\024\030\t\b \017\f\023\024\035\034\024\r\026\027\017\036 \204\ \210 \023\030\017\n\036\027\016\035\024\f\034 \021\024\035\034\022\024 )Tj -0.011 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC (\220\021\026\023\036 \026\027\026\035\017\026 \030\036\031\035\034\021\ \026\021\024\r \r)Tj /Span<>> BDC ( )Tj EMC (\022\026\004\036\f\021\r\036 \017\027\f\021\030\031\n\036\027\021\026 )Tj 0.085 Tw T* (\f\021\026\021\017\f\021\017\022\017. \200)Tj /Span<>> BDC ( )Tj EMC (\030\036\031\035\034\021\026\021\036 \002\t\035\017 \024\021\024\002\030\ \026\027\t 112)Tj /Span<>> BDC ( )Tj EMC (\f\021\026\021\036\005, )Tj 0.104 Tw T* (\017\031\004\036\027 \023\024\035\027\t\005 \021\036\022\f\021 \030\026\ \002\024\021. \215\024\f\035\036 \017\031\004\036\027\017\016 \023\024\035\ \027\t\b )Tj 0.219 Tw T* [(\021\036\022\f\021\024\r )0.5(\f\021\026\021\036\005 \002\t\035\017 )0.5(\024\021\024\002\030\026\027\t \030\026\002\024\021\t, )0.5(\n\024\007\036\035\017 \n\026)]TJ 0 Tw (-)Tj 0.138 Tw T* (\001\017\027\027\024\020\024 \024\002\031\004\036\027\017\016 \r)Tj /Span<>> BDC ( )Tj EMC (\022\024\021\024\030\t\b \r)Tj /Span<>> BDC ( )Tj EMC (\b\024\007\036 \r\026\035\017\007\026\006\017\017 \023\024)Tj 0 Tw (-)Tj 0.147 Tw T* (\022\026\026\035\017 \021\024\004\027\024\f\021\034 \002\024\035\036\036\ 80%. \212\035\016 \027\026\023\017\f\026\027\017\016 \007\026\027\027\024\ \005 )Tj 0.232 Tw T* (\030\026\002\024\021\t \017\f\023\024\035\034\024\r\026\027\t \030\036\ \031\035\034\021\026\021\t 41)Tj /Span<>> BDC ( )Tj EMC (\024\030\017\020\017\027\026\035\034\027\024\005 )Tj 0 Tw T* (\023\031\002\035\017\022\026\006\017\017 $\217\017\f.)Tj /Span<>> BDC ( )Tj EMC (1$.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 303.3769 444.7358 Tm [(\033\034\020)21(\223)50(\r\241)46(\024)52(\026)45(\024\232)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf 0 Tc 0.141 Tw 10 0 0 10 303.3071 420.3798 Tm (\203\016\024\035\034 \f\033\016\004\022\021\035\022\036\020\032 \003\034\ \004\016\027\016\b \003\037\235\022\020\020\034\013\034 \034\025\023\201\ \016\020\022\030 )Tj 0.048 Tw T* (\036)Tj /Span<>> BDC ( )Tj EMC (\f\033\034\013\020\034\031\022\033\034\036\037\020\022\022 \022\024\034\ \004\037 \f\033\022)Tj /Span<>> BDC ( )Tj EMC (\033\037\031\027\022\201\020\032 \036\037\033\022\037\020\035\037 )Tj 0 Tw T* (\036\032\025\033\037\020\020\034\b \035\016\033\037\f\016\036\035\022\201\ \016\024\021\034\b \024\035\033\037\035\016\013\022\022.)Tj 0.508 Tw 0 -2.436 TD (1.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (\207\033\034\013\020\034\031\022\033\034\036\037\020\022\016 \034\035\036\ \016\035\037 \020\037)Tj /Span<>> BDC ( )Tj EMC (\020\016\034\037\004\213\026\036\037\020\035\020\034\016 )Tj 0 Tw -1.296 -1.218 Td (\022)Tj /Span<>> BDC ( )Tj EMC (\037\004\213\026\036\037\020\035\020\034\016 \027\016\201\016\020\022\016\ )Tj /T1_0 1 Tf 0.01 Tc 0.23 Tw 0 -1.218 TD [(\215\030\017 \n\036\f\021\027\024\030\026\f\023\030\024\f\021\030\026\027\ \036\027\027\024\n \030\026\022\036 \023\030\016\n\024\005 \022\017\001\022\ \017)10( )]TJ 0.411 Tw T* ($\204\217\217\215\025$ \f\021\026\027\007\026\030\021\024\n \035\036\004\ \036\027\017\016 \016\r\035\016\036\021\f\016 \023\030\036\007\024\023\036\ )Tj 0 Tc 0 Tw (-)Tj 0.01 Tc 0.565 Tw T* [(\030\026\006\017\024\027\027\026\016 )0.5(\027\036\024\026\007\255\033\r\026\027\021\027\026\016 )0.5(\b\017\n\017\024\035\031\004\036\r\026\016 )0.5(\021\036\030\026)]TJ 0 Tc 0 Tw (-)Tj 0.01 Tc 0.272 Tw T* (\023\017\016 $\203\202\216\214\231$ \f)Tj /Span<>> BDC ( )Tj EMC (\023\024\f\035\036\007\031\033\013\036\005 \024\006\036\027\022\024\005 \ \017)Tj /Span<>> BDC ( )Tj EMC (\b\017\030\031\030\020\017)Tj 0 Tc 0 Tw (-)Tj 0.01 Tc 0.508 Tw T* (\004\036\f\022\017\n 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(\007\017\026\020\027\024\f\021\017\022\017 \017)Tj /Span<>> BDC ( )Tj EMC (\035\036\004\036\027\017\016, \027\024 \017)Tj /Span<>> BDC ( )Tj EMC (\024\021\022\030\t\021\017\016 \r)Tj /Span<>> BDC ( )Tj EMC (\024\002\035\026\f\021\017 )Tj 0.318 Tw T* (\n\024\035\036\022\031\035\016\030\027\024\005 \002\017\024\035\024\020\017\ \017. \200\024\n\024\032\027\024\f\021\034 \024\002\n\036\027\026 \030\036\ )Tj 0 Tw (-)Tj 0.204 Tw T* (\031\035\034\021\026\021\026\n\017 \020\036\027\024\n\027\024\020\024 \023\ \030\024\235\017\035\017\030\024\r\026\027\017\016 \025\217\217 \r)Tj /Span<>> BDC ( )Tj EMC (\030\026\n)Tj 0 Tw (-)Tj 0.142 Tw T* (\022\026\b \023\030\024\020\030\026\n\n\t \023\024)Tj /Span<>> BDC ( )Tj EMC (\f\024\007\026\027\017\033 \020\036\027\024\n\027\024\020\024 \026\021\035\ \026\f\026 \030\026\022\026 )Tj 0.112 Tw T* [($T)47(he )0.5(Cancer )0.6(Genome )0.5(A)30(tl)-16(as )0.5(\(T)35(GC)20(A$ )0.6(P)35(r)-32(o)-16(gr)-33(am\) )0.5(\f\021\026\035\024 )0.6(\024\007)]TJ 0 Tw (-)Tj 0.342 Tw T* (\027\017\n \017)Tj /Span<>> BDC ( )Tj EMC (\027\026\004\017\021\036\035\034\027\t\b \007\024\f\021\017\032\036\027\ \017\005 \023\024\f\035\036\007\027\017\b \035\036\021. )Tj 0.172 Tw T* [(\225\036\005\004\026\f )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 4.105 0 Td [(\022\035\017\027\017\004\036\f\022\024\005 )0.6(\023\030\026\022\021\017\022\036 )0.5(\016\r\035\016\036\021\f\016 )0.6(\030\031\021\017\027\027\t\n )]TJ 0.061 Tw -4.105 -1.218 Td [(\024\002\027\026\030\031\032\036\027\017\036 )0.6(\n\031\021\026\006\017\005 )0.5(\f\017\020\027\026\035\034\027\024\020\024 )0.6(\023\031\021\017 )0.5(RA)35(S-RAF )0.6(\022\026\022 )]TJ -0.006 Tw T* (\024\f\027\024\r\027\t\b \007\036\021\036\030\n\017\027\026\027\021 \024\ \021\r\036\021\026 \027\026)Tj /Span<>> BDC ( )Tj EMC (\026\027\021\017\021\036\035\026 \023\030\024\021\017\r \030\036)Tj 0 Tw (-)Tj 0.064 Tw T* (\006\036\023\021\024\030\026 \220\023\017\007\036\030\n\026\035\034\027\024\ \020\024 \235\026\022\021\024\030\026 \030\024\f\021\026. \025\030\024\n\ \036 \021\024\020\024, )Tj 0.117 Tw T* (\023\024\035\031\004\036\027\017\036 \007\026\027\027\t\b \024\002 \026\n\ \023\035\017\235\017\022\026\006\017\017 HER2, \027\026\035\017\004\017\017\ )Tj 0.405 Tw T* (\n\031\021\026\006\017\005 \f\017\020\027\026\035\034\027\024\020\024 \023\ \031\021\017 MAP-\022\017\027\026\t, \030\036\031\035\034\021\026)Tj 0 Tw (-)Tj 0.51 Tw T* [(\021\t MSI-\021\036\f\021\017\030\024\r\026\027\017\016 )0.5(\007\035\016 \021\036\030\026\023\017\017 \017\027\020\017\002\017\021\024\ \030\026\n\017 )]TJ 0.156 Tw T* (\022\024\027\021\030\024\035\034\027\t\b \017\n\n\031\027\027\t\b \021\024\ \004\036\022)Tj /Span<>> BDC ( )Tj EMC (\227 \220\021\017 \027\024\r\t\036 \007\026\027\027\t\036 )Tj 0.379 Tw T* [(\023\024\r\024\035\017\035\017 )0.6(\024\027\022\024\035\024\020\026\n )0.5(\017\027\007\017\r\017\007\031\026\035\017\017\030\024\r\026\021\034 )0.6(\n\036\007\017)]TJ 0 Tw (-)Tj 0.31 Tw T* (\022\026\n\036\027\021\024\027\031\033 \021\036\030\026\023\017\033 \027\ \026)Tj /Span<>> BDC ( )Tj EMC (\024\f\027\024\r\036 \031\027\017\022\026\035\034\027\024\020\024 \n\024\ )Tj 0 Tw (-)Tj 0.264 Tw T* (\035\036\022\031\035\016\030\027\024\020\024 \023\030\024\235\017\035\016\ \024\023\031\b\024\035\017 \023\026\006\017\036\027\021\026, \024\f\024\ \002\036\027\027\024 )Tj 0 Tw T* (\023\030\017)Tj /Span<>> BDC ( )Tj EMC (\035\036\004\036\027\017\017 \n\036\021\026\f\021\026\021\017\004\036\f\022\ \024\020\024 \025\217\217 [2].)Tj 0.238 Tw 23.244 30.445 Td (\215\030\017 \220\021\024\n \f\036\005\004\026\f \r)Tj /Span<>> BDC ( )Tj EMC [(\002\026\036 T)35(GC)20(A \023\030\036\007\f\021\026\r\035\036\027\t \002\024\035\036\036 )]TJ -0.016 Tw T* (20)Tj /Span<>> BDC ( )Tj EMC 1.216 0 Td [(000 )0.6(\020\036\027\024\r, )0.5(\007\035\016 )0.5(\022\024\021\024\030\t\b )0.6(\017\031\004\036\027\t )0.6(\026\f\f\024\006\017\026\006\017\017 )0.6(\f)]TJ /Span<>> BDC ( )Tj EMC 19.128 0 Td (\025\217\217, )Tj 0.105 Tw -20.344 -1.218 Td (\004\021\024 \007\026\036\021 \027\026\n \r\024\n\024\032\027\024\f\021\ \034 \023\030\036\007\023\024\035\024\032\017\021\034 \023\024\016\r\035\ \036\027\017\036 )Tj 0.046 Tw T* (\036\013\036 \002\024\035\034\001\036\020\024 \022\024\035\017\004\036\f\ \021\r\026 \020\036\027\036\021\017\004\036\f\022\017\b \023\030\036\007\ \017\022\021\024\030\024\r )Tj 0 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\035\036\004\036\027\017\017 \025\217\217 \031\032\036 \r)Tj /Span<>> BDC ( )Tj EMC (\002\035\017\032\026\005\001\036\036 \r\030\036\n\016.)Tj 0.265 Tw T* (\224\027\021\036\027\f\017\r\027\024\f\021\034 \027\026\031\004\027\t\b \ \017\f\f\035\036\007\024\r\026\027\017\005, \024\f\027\024\r\026\027\027\ \t\b )Tj 0.275 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC (\030\026\f\021\031\013\036\n \023\024\027\017\n\026\027\017\017 \024\023\ \031\b\024\035\036\r\024\005 \f\017\020\027\026\035\017\026\006\017\017\ )Tj 0.047 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\n\036\b\026\027\017\n\026\b \022\026\027\006\036\030\024\020\036\027\036\ \026 \027\026)Tj /Span<>> BDC ( )Tj EMC (\n\024\035\036\022\031\035\016\030\027\024\n \031\030\024\r)Tj 0 Tw (-)Tj 0.188 Tw T* [(\027\036 \007\036\035\026\036\021 \026\030\b\026\017\004\027\024\005 \021\ \030\026\007\017\006\017\024\027\027\031\033 )0.5(\027\036\f\036\035\036\022\021\017\r\027\031\033 )]TJ 0.099 Tw T* [(\006\017\021\024\021\024\022\f\017\004\036\f\022\031\033 )0.6(\b\017\n\017\024\021\036\030\026\023\017\033, )0.6(\023\024\f\021\036\023\036\027\027\024 )0.5(\030\026\f\001\017)]TJ 0 Tw (-)Tj 0.09 Tw T* [(\030\016\016 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC (\007\026\032\036 \r)Tj /Span<>> BDC ( )Tj EMC 5.811 0 Td [(\027\036\022\024\021\024\030\t\b )0.5(\f\035\031\004\026\016\b )0.5(\r\t\021\036\f\027\016\016 )0.5(\036\036 \f\036\035\036\022)]TJ 0 Tw (-)Tj 0.02 Tw -5.811 -1.218 Td (\021\017\r\027\t\n\017 \021\026\030\020\036\021\027\t\n\017 \023\030\036\ \023\026\030\026\021\026\n\017 [3]. \224\f\b\024\007\016 \017)Tj /Span<>> BDC ( )Tj EMC (\r\t)Tj 0 Tw (-)Tj 0.032 Tw T* (\001\036\017\035\024\032\036\027\027\024\020\024, \023\036\030\f\023\036\ \022\021\017\r\026 \023\036\030\f\024\027\026\035\017\017\030\024\r\026\ \027\027\024\020\024 )Tj 0.072 Tw T* [(\035\036\004\036\027\017\016 )0.6(\025\217\217, )0.5(\022\024\021\024\030\024\036 )0.5(\002\t\035\024 )0.6(\002\t )0.5(\024\023\021\017\n\026\035\034\027\t\n )0.6(\007\035\016 )0.5(\023\026)]TJ 0 Tw (-)Tj 0.028 Tw T* [(\006\017\036\027\021\024\r )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC [(\024\002\036\f\023\036\004\017\r\026\035\024 )0.5(\002\t \035\031\004\001\017\005 \022\035\017\027\017\004\036\f\022\017\005\ )0.5(\030\036)]TJ 0 Tw (-)Tj -0.018 Tw T* (\031\035\034\021\026\021, \031\032\036 \027\036 \016\r\035\016\036\021\f\ \016 \235\026\027\021\026\f\021\017\022\024\005, \026)Tj /Span<>> BDC ( )Tj EMC (\r \002\035\017\032\026\005\001\017\036 )Tj 0.133 Tw T* (\020\024\007\t \f\021\026\027\036\021 \030\031\021\017\027\027\024\005 \022\ \035\017\027\017\004\036\f\022\024\005 \023\030\026\022\021\017\022\024\005\ , \004\036\n\031 )Tj 0.083 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\027\026\004\017\021\036\035\034\027\024\005 \f\021\036\023\036\027\017\ \f\023\024\f\024\002\f\021\r\031\036\021 \030\026\r\017\021\017\036 \022\ \024\n)Tj 0 Tw (-)Tj -0.036 Tw T* (\023\034\033\021\036\030\027\t\b \021\036\b\027\024\035\024\020\017\005 \ \017, \r)Tj /Span<>> BDC ( )Tj EMC (\004\026\f\021\027\024\f\021\017, \017\f\022\031\f\f\021\r\036\027\027\024\ \020\024 )Tj 0 Tw T* (\017\027\021\036\035\035\036\022\021\026 $\224\224$.)Tj 0.182 Tw T* (\224\224 \016\r\035\016\036\021\f\016 \f\023\036\006\017\026\035\017\017\ \030\024\r\026\027\027\024\005 \024\021\030\026\f\035\034\033 \r\t\004\017\ \f)Tj 0 Tw (-)Tj 0.16 Tw T* (\035\017\021\036\035\034\027\024\005 \021\036\b\027\017\022\017, \r\t\023\ \024\035\027\016\033\013\036\005 \030\026\035\017\004\027\t\036 \235\031\ \027\022)Tj 0 Tw (-)Tj 0.394 Tw T* (\006\017\017, \r\022\035\033\004\026\016 \023\030\024\020\027\024\017\030\ \024\r\026\027\017\036 \017)Tj /Span<>> BDC ( )Tj EMC (\022\035\026\f\f\017\235\017\022\026\006\017\033 )Tj 0.196 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC (\024\f\027\024\r\036 \f\031\013\036\f\021\r\031\033\013\017\b \007\026\027\ \027\t\b [4]. \200)Tj /Span<>> BDC ( )Tj EMC (\027\026\f\021\024\016\013\017\005 )Tj 0.176 Tw T* [(\023\036\030\017\024\007 )0.5(\030\026\r\017\021\017\016 )0.6(\n\036\007\017\006\017\027\t )0.5(\024)]TJ /Span<>> BDC ( )Tj EMC 13.075 0 Td [(\023\024\035\027\024\006\036\027\027\024\n )0.6($\253\f\017\035\034)]TJ 0 Tw (-)Tj 0.118 Tw -13.075 -1.218 Td [(\027\024\n\273$ )0.5(\224\224 \020\024\r\024\030\017\021\034 )0.5(\036\013\036 \030\026\027\024, )0.5(\f\036\005\004\026\f )0.5(\220\021\024 \r)]TJ /Span<>> BDC ( )Tj EMC 18.534 0 Td (\002\024\035\034\001\036\005 )Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 0 Tw 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\205)10(\210\036\033 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$\002\b.\022)-23.3(\035\t\004\005\004\r\017\005\t \006)10(\025\235\007, )]TJ -0.331 -1.2 Td [(\207.\022)-23.3(1)69(, \006)62(.\022)-23.2(\215\025\r\017\f\016, 1)212(1)138(999)125(1)69(, \033\025\r\r\005\200$)]TJ /T1_0 1 Tf 0.046 Tw 9 0 0 9 119.0551 556.6488 Tm (\214\220\222\225: \022\031\023\201\022\035\215 \024\034\036\033\016\003\016\ \020\020\032\016 \f\034\004\034\004\032 \021)Tj /Span<>> BDC ( )Tj EMC (\f\033\022\003\016\020\016\020\022\026 \035\016\020\034\027\034\013\022\ \b \003\037\235\022\020\020\034\013\034 \034\025\023\201\016\020\022\030\ \022)Tj /Span<>> BDC ( )Tj EMC (\013\027\023\025\034\021\034\013\034 \034\025\023\201\016\020\022\030 )Tj 0.023 Tw 0 -1.111 TD (\020\037)Tj /Span<>> BDC ( )Tj EMC (\033\037\031\027\022\201\020\032 \204\035\037\f\037 \036\016\004\016\020\ \022\030 \025\034\027\215\020\032 \021\034\027\034\033\016\021\035\037\027\ \215\020\032\003 \033\037\021\034\003.)Tj 0.003 Tw T* (\203\223\205\220\210\200\223\222\230 \200)Tj /Span<>> BDC ( )Tj EMC (\203\220\205\216\007\230: \f\033\034\036\016\004\016\020 \037\020\037\027\ \022\031 \034\f\023\025\027\022\021\034\036\037\020\020\032 \004\037\020\ \020\032 \036)Tj /Span<>> BDC ( )Tj EMC (National Library of Medicine $\025\037\031\037 \004\037\020\020\032 )Tj -0.006 Tw T* (Pubmed$ \031\037)Tj /Span<>> BDC ( )Tj EMC (\f\034\024\027\016\004\020\022\016 5 \027\016\035. \207\034\024\027\016 \ \024\021\033\022\020\022\020\013\037 398 \f\023\025\027\022\021\037\n\022\ \b \034\035\034\025\033\037\020\032 112 \024\035\037\035\016\b, \022\031\ \023\201\016\020 \f\034\027\020\032\b \035\016\021\024\035 )Tj 0.205 Tw T* (\033\037\025\034\035. \207\034\024\027\016 \022\031\023\201\016\020\022\030\ \f\034\027\020\032 \035\016\021\024\035\034\036 \024\035\037\035\016\b\ \025\032\027\022 \034\035\034\025\033\037\020\032 \033\037\025\034\035\032\ , \003\034\004\016\027\022 \003\037\235\022\020\020\034\013\034 \034\025\ \023\201\016\020\022\030 )Tj 0.072 Tw T* (\036)Tj /Span<>> BDC ( )Tj EMC 0.771 0 Td (\021\034\035\034\033\032 \036)Tj /Span<>> BDC ( )Tj EMC 4.738 0 Td [(\034\004\016 )0.5(\036\037\027\022\004\037\n\022\022 )0.5(\f\034\021\037\031\037\027\022 )0.5(\035\034\201\020\034\024\035\215 )0.5(\025\034\027\016\016 )0.5(80%. )0.5(\007\027\030 )0.5(\020\037\f\022\024\037\020\022\030 )0.5(\004\037\020\020\034\b \033\037\025\034\035\032 \022\024\f\034\027\215\031\ \034\036\037\020\032 )]TJ 0.023 Tw -5.509 -1.111 Td (\033\016\031\023\027\215\035\037\035\032 41 \034\033\022\013\022\020\037\ \027\215\020\034\b \f\023\025\027\022\021\037\n\022\022.)Tj -0.002 Tc 0.049 Tw T* (\210\220\255\240\222\225\205\223\205\230: \023\004\037\027\034\024\215 \036\ \032\004\016\027\022\035\215 \020\016\024\021\034\027\215\021\034 \020\037\ \f\033\037\036\027\016\020\022\b, \030\036\027\030\026\202\022\024\030 \ \020\037\022\025\034\027\016\016 \f\016\033\024\f\016\021\035\022\036\020\ \032\003\022 \004\027\030 \f\033\022\003\016)Tj 0 Tc 0 Tw (-)Tj -0.002 Tc -0.004 Tw 0 -1.111 TD (\020\016\020\022\030 \035\016\020\034\027\034\013\022\b \022\024\021\023\ \024\024\035\036\016\020\020\034\013\034 \022\020\035\016\027\027\016\021\ \035\037 \f\033\022)Tj /Span<>> BDC ( )Tj EMC (\036\016\004\016\020\022\022 \025\034\027\215\020\032 \021\034\027\034\033\ \016\021\035\037\027\215\020\032\003 \033\037\021\034\003: \f\033\034\013\ \020\034\031\022\033\034\036\037)Tj 0 Tc 0 Tw (-)Tj -0.002 Tc 0.04 Tw 0 -1.111 TD (\020\022\016 \034\035\036\016\035\037 \020\037)Tj /Span<>> BDC ( )Tj EMC (\020\016\034\037\004\213\026\036\037\020\035\020\034\016 \027\016\201\016\ \020\022\016, \f\033\034\013\020\034\031\022\033\034\036\037\020\022\016\ \033\022\024\021\034\036 \034\035\004\037\027\016\020\020\034\013\034 \003\ \016\035\037\024\035\037\031\022\033\034\036\037\020\022\030 \022)Tj /Span<>> BDC ( )Tj EMC (\033\016\n\022)Tj 0 Tc 0 Tw (-)Tj -0.002 Tc 0.142 Tw T* (\004\022\036\022\033\034\036\037\020\022\030 \031\037\025\034\027\016\036\ \037\020\022\030, \f\033\034\013\020\034\031\022\033\034\036\037\020\022\ \016 \035\034\021\024\022\201\020\034\024\035\022 \022\003\022\034\035\016\ \033\037\f\022\022, \034\n\016\020\021\037 \033\022\024\021\034\036 \020\ \016\024\034\024\035\034\030\035\016\027\215\020\034)Tj 0 Tc 0 Tw (-)Tj -0.002 Tc 0.091 Tw T* (\024\035\022 \021\034\027\034\033\016\021\035\037\027\215\020\032 \037\020\ \037\024\035\034\003\034\031\034\036. \206)Tj /Span<>> BDC ( )Tj EMC [(\021\037\201\016\024\035\036\016 \020\037\022\025\034\027\016\016 \f\016\ \033\024\f\016\021\035\022\036\020\032 \017\037\021\035\034\033\034\036\ , \021\034\035\034\033\032\016 \003\034\013\023\035 \025\032\035\215)-2( )]TJ 0.174 Tw T* [(\022\024\f\034\027\215\031\034\036\037\020\032 \004\027\030 \034\025\023\ \201\016\020\022\030 \003\034\004\016\027\016\b, \022\024\024\027\016\004\ \034\036\037\035\016\027\022 \033\037\024\024\003\037\035\033\022\036\037\ \026\035 \021\027\022\020\022\201\016\024\021\022\016 \f\034\021\037\031\ \037\035\016\027\022, \022\003\003\023\020\020\034\016)-2( )]TJ 0.101 Tw T* (\034\021\033\023\t\016\020\022\016 \034\f\023\034\027\022, \210\002\r-\024\ \022\013\020\037\035\023\033\032 \034\f\023\034\027\022, \037)Tj /Span<>> BDC ( )Tj EMC [(\035\037\021\t\016 \036\022\031\023\037\027\215\020\032\016 \f\037\035\034\ \003\034\033\017\034\027\034\013\022\201\016\024\021\022\016 \037\033\037\ \021\035\016\033\022\024\035\022\021\022.)-2( )]TJ 0.022 Tw T* (\002\037\022\025\034\027\215\235\016\b \035\034\201\020\034\024\035\215\026\ \037\033\037\021\035\016\033\022\031\034\036\037\027\022\024\215 \003\034\ \004\016\027\022, \f\033\016\004\020\037\031\020\037\201\016\020\020\032\ \016 \004\027\030 \f\033\016\004\024\021\037\031\037\020\022\030 \033\022\ \024\021\037 \003\016\035\037\024\035\022\035\022)Tj 0 Tc 0 Tw (-)Tj -0.002 Tc -0.018 Tw T* [(\201\016\024\021\034\013\034 )0.5(\f\034\033\037\t\016\020\022\030 )0.5(\f\016\201\016\020\022 )0.6(\023)]TJ /Span<>> BDC ( )Tj EMC 11.699 0 Td [(\f\037\n\022\016\020\035\034\036 )0.5(\024)]TJ /Span<>> BDC ( )Tj EMC 5.401 0 Td [(T1-\024\035\037\004\022\016\b )0.5($AUC)]TJ /Span<>> BDC ( )Tj EMC 7.152 0 Td (=)Tj /Span<>> BDC ( )Tj EMC 0.71 0 Td [(0,9631$, )0.6(\037)]TJ /Span<>> BDC ( )Tj EMC 4.223 0 Td [(\035\037\021\t\016 )0.5(\003\034\004\016\027\022, )0.5(\020\037\f\033\037\036\027\016\020\020\032\016 )0.5(\020\037)]TJ /Span<>> BDC ( )Tj EMC 13.632 0 Td (\034\n\016\020)Tj 0 Tc 0 Tw (-)Tj -0.002 Tc 0.063 Tw -42.816 -1.111 Td (\021\023 \033\022\024\021\037 30-\035\022 \004\020\016\036\020\034\b \027\ \016\035\037\027\215\020\034\024\035\022 \020\037)Tj /Span<>> BDC ( )Tj EMC (\017\034\020\016 \022\003\022\034\035\016\033\037\f\022\022 $AUC)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,924$. \006\034\027\215\235\022\020\024\035\036\034 \022\031)Tj /Span<>> BDC ( )Tj EMC [(\034\025\024\023\t\004\037\016\003\032)-2( )]TJ 0.039 Tw 0 -1.111 TD (\036)Tj /Span<>> BDC ( )Tj EMC (\033\037\025\034\035\016 \035\016\020\034\027\034\013\022\b \f\033\016\004\ \024\035\037\036\027\030\026\035 \022\031)Tj /Span<>> BDC ( )Tj EMC (\024\016\025\030 \f\033\034\013\033\037\003\003\020\032\016 \f\033\034\004\ \023\021\035\032, \034\025\023\201\016\020\020\032\016 \020\037)Tj /Span<>> BDC ( )Tj EMC (\033\037\031\027\022\201\020\032 \f\034)Tj /Span<>> BDC ( )Tj EMC [(\021\037\201\016\024\035\036\023)-2( )]TJ 0.018 Tw 0 -1.111 TD (\022)Tj /Span<>> BDC ( )Tj EMC (\021\034\027\022\201\016\024\035\036\023 \020\037\025\034\033\037 \004\037\ \020\020\032, \021\034\035\034\033\032\016 \024\f\034\024\034\025\020\032\ \f\034\004\024\021\037\031\037\035\215 \024\n\016\020\037\033\022\b \027\ \016\201\016\020\022\030 \020\037)Tj /Span<>> BDC ( )Tj EMC (\034\024\020\034\036\016 \f\033\034\013\020\034\031\020\032 \003\034\004\ \016)Tj 0 Tc 0 Tw (-)Tj -0.002 Tc 0.023 Tw T* (\027\016\b, \022, \f\034)Tj /Span<>> BDC ( )Tj EMC (\024\023\035\022, \003\034\013\023\035 \036\032\024\035\023\f\037\035\215\ \036)Tj /Span<>> BDC ( )Tj EMC (\021\037\201\016\024\035\036\016 \f\034\003\034\202\020\022\021\037 \036\ \033\037\201\037 \024)Tj /Span<>> BDC ( )Tj EMC (\034\201\016\020\215 \034\013\033\037\020\022\201\016\020\020\032\003 \017\ \023\020\021\n\022\034\020\037\027\034\003.)Tj 0 Tc 0.083 Tw T* (\255\223\r\222\231\232\220\002\200\220: \035\016\021\023\202\022\b \023\033\ \034\036\016\020\215 \033\037\031\036\022\035\022\030 \n\022\017\033\034\ \036\032 \035\016\020\034\027\034\013\022\b \036)Tj /Span<>> BDC ( )Tj EMC (\034\020\021\034\027\034\013\022\022, \037)Tj /Span<>> BDC ( )Tj EMC (\022\003\016\020\020\034 \036)Tj /Span<>> BDC ( )Tj EMC (\027\016\201\016\020\022\022 \r\210\210, \020\016 )Tj 0.09 Tw T* (\f\034\031\036\034\027\030\016\035 \013\034\036\034\033\022\035\215 \034\ )Tj /Span<>> BDC ( )Tj EMC (\f\034\027\020\034\n\016\020\020\034\003 \200\200, \024\f\034\024\034\025\ \020\034\003 \f\033\022\020\022\003\037\035\215 \033\016\235\016\020\022\ \030 \034)Tj /Span<>> BDC ( )Tj EMC (\027\016\201\016\020\022\022 \f\037\n\022\016\020\035\034\036 \025\016\031\ \036\033\037\201\016\025)Tj 0 Tw (-)Tj 0.129 Tw T* (\020\034\013\034 \021\034\020\035\033\034\027\030. \007\016\b\024\035\036\ \022\035\016\027\215\020\034 \f\016\033\024\034\020\022\017\022\n\022\033\ \034\036\037\020\020\032\016 \024\016\003\032 \027\016\201\016\020\022\030\ , \034\024\020\034\036\037\020\020\032\016 \020\037)Tj /Span<>> BDC ( )Tj EMC (\003\022\021\033\034\025\022\034\035\022\201\016\024\021\034\003 )Tj -0.003 Tw T* (\022)Tj /Span<>> BDC ( )Tj EMC [(\003\023\035\037\n\022\034\020\020\034\003 )0.5(\024\f\016\021\035\033\016 \022, \020\037\f\033\022\003\016\033, \f\016\033\ \024\034\020\037\027\215\020\034\b )0.5(\017\037\033\003\037\021\034\021\022\020\016\035\022\021\016, \f\034\021\ \037 \201\035\034 \036\032\013\027\030\004\030\035 \017\037\020\035\037\024\ \035\022\201\016\024\021\022)]TJ 0 Tw (-)Tj 0.023 Tw T* (\003\022, \020\034, \025\016\031\023\024\027\034\036\020\034, \f\016\033\ \024\f\016\021\035\022\036\020\032\003\022 \004\027\030 \025\023\004\023\ \202\022 \033\037\031\033\037\025\034\035\034\021.)Tj /T1_2 1 Tf 0.01 Tc 0.017 Tw 8 0 0 8 70.9061 301.3796 Tm [(\037\033\005\004\030\025\003\030)5( \026\033\036\025\021:)]TJ /T1_0 1 Tf 0 Tc 0.022 Tw 8.492 0 Td ( \021\034\027\034\033\016\021\035\037\027\215\020\032\b \033\037\021, \027\ \016\201\016\020\022\016, \034\f\035\022\003\037\027\215\020\037\030 \024\ \035\033\037\035\016\013\022\030, \022\024\021\023\024\024\035\036\016\020\ \020\032\b \022\020\035\016\027\027\016\021\035, \013\027\023\025\034\021\ \034\016 \034\025\023\201\016\020\022\016, \003\037\235\022\020\020\034\016\ )Tj 0 Tw -8.497 -1.2 Td (\034\025\023\201\016\020\022\016)Tj /T1_2 1 Tf 0.01 Tc 0.018 Tw 0.005 -1.909 Td [(\037\036\035\034\033\032\037\031)5( \032\035\031\030\027\030\026\036\025:)]TJ /T1_0 1 Tf 0 Tc 0.023 Tw 10.401 0 Td ( \037\036\035\034\033\032 \031\037\030\036\027\030\026\035 \034\025 \034\ \035\024\023\035\024\035\036\022\022 \021\034\020\017\027\022\021\035\037\ \022\020\035\016\033\016\024\034\036)Tj /T1_2 1 Tf 0.033 Tc 0.093 Tw -10.401 -2.617 Td [(\024\033\023)4.7( \022\032\031\032\027\036\025\021\035\032\023:)]TJ /T1_3 1 Tf 0.023 Tc 0.098 Tw 9.265 0 Td ( \025\030\026\r\004\036\027\022\024)Tj /Span<>> BDC ( )Tj EMC (\202.\222., \225\036\n\017\027\026)Tj /Span<>> BDC ( )Tj EMC (\213.\200., \025\026\022\024\021\022\017\027)Tj /Span<>> BDC ( )Tj EMC (\200.\200., \202\020\026\023\024\r)Tj /Span<>> BDC ( )Tj EMC (\204.\202. \200\024\n\024\032\027\024\f\021\017 \017)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\f\023\036\022\021\017\r\t \023\030\017\n\036\027\036\027\017\ \016 \017\f\022\031\f)Tj 0 Tc 0 Tw (-)Tj 0.023 Tc 0.18 Tw -9.27 -1.2 Td (\f\021\r\036\027\027\024\020\024 \017\027\021\036\035\035\036\022\021\026\ \r)Tj /Span<>> BDC ( )Tj EMC (\035\036\004\036\027\017\017 \022\024\035\024\030\036\022\021\026\035\034\ \027\024\020\024 \030\026\022\026 $\024\002\024\030 \035\017\021\036\030\ \026\021\031\030\t$. )Tj /T1_0 1 Tf -0.023 Tw (\r\034\027\034\f\033\034\021\035\034\027\034\013\022\030.)Tj /T1_3 1 Tf 0.18 Tw ( 2024; \021.)Tj /Span<>> BDC ( )Tj EMC (23, \223)Tj /Span<>> BDC ( )Tj EMC (2, \f.)Tj /Span<>> BDC ( )Tj EMC [(184\226193.)23( )]TJ -0.023 Tw 0 -1.2 TD (https://doi.org/10.33878/2073-7556-2024-23-2-184-193)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0 Tc 0.023 Tw 18 0 0 18 121.373 204.0332 Tm [(P)10(ossibilities and pr)20(ospects of ar)-20(tif)-21(icial intelligence )]TJ 0.909 -1.167 Td [(in th)11(e tr)31(eatment of color)31(ectal cancer $r)31(e)11(vie)11(w$)]TJ 0 0 0 1 k /GS1 gs 0 Tw 14 0 0 14 70.8661 158.5293 Tm [(Alek)11(sander\022)-23.2(Y)40(u.\022)-23.3(Kr)21(av)10(ch)11(enk)11(o)]TJ 8.162 0 0 8.162 224.1165 163.1913 Tm (1)Tj 0.023 Tw 14 0 0 14 228.7525 158.5293 Tm [(, Ekaterina\022)-23.2(V)62(.\022)-23.3(Semina)]TJ -0.069 Tc 0.069 Tw 8.162 0 0 8.162 348.8826 163.1913 Tm [(1,)-69(2)]TJ 0 Tc 0.023 Tw 14 0 0 14 360.2032 158.5293 Tm [(, Viktor\022)-23.2(V)62(.\022)-23.3(K)41(ak)11(otkin)]TJ 0 Tw 8.162 0 0 8.162 467.6355 163.1913 Tm (1)Tj 14 0 0 14 472.2715 158.5293 Tm (, )Tj -28.672 -1.143 Td [(Mikhail\022)-23.2(A)-31(.\022)-23.3(Agapov)]TJ -0.069 Tc 0.069 Tw 8.162 0 0 8.162 177.9866 147.1913 Tm [(1,)-69(2)]TJ 0 Tc 0 Tw 5.83 0 0 5.83 70.8661 128.19 Tm (1)Tj 0.023 Tw 10 0 0 10 74.1775 124.86 Tm [(Immanuel K)41(ant Baltic F)19.9(eder)21.1(al Univ)12(er)20(sit)-19.9(y $A)-31(. Ne)11(v)10(sk)11.1(ogo\022)-23.3(st., 1)150(4, K)41(aliningr)21.1(ad, 2360)25.1(4)102.9(1)69(, Russia$)]TJ 0 Tw ( )Tj 5.83 0 0 5.83 70.8661 116.19 Tm (2)Tj 0.023 Tw 10 0 0 10 74.1775 112.86 Tm [(Lomonosov Moscow State Univ)12.1(er)20(sit)-20(y $Leninskie Gor)-31(y\022)-23.3(st., 1)69(, Moscow)22(, 1)212(1)138(999)125(1)69(, Russia$)]TJ /T1_0 1 Tf 0.096 Tw 9 0 0 9 119.0551 94.3561 Tm [(AIM: to study moder)-13.9(n app)46(roaches to the application of machine lear)-14(ning and deep lear)-13.9(ning technologies for the )]TJ 0.023 Tw 0 -1.111 TD [(manag)12(ement of patients with colorectal cancer)51.1(.)]TJ ET 1 0.68 0 0.12 k /GS0 gs q 1 0 0 1 70.8661 565.1533 cm 0 0 m 0 0 l 0 -11.339 l 42.52 -11.339 l 42.52 0 l h f Q BT 0 0 0 0 k /T1_2 1 Tf 0 Tw 9 0 0 9 76.0071 556.226 Tm (\027\030\002\005\001\030)Tj ET 1 0.68 0 0.12 k q 1 0 0 1 70.8661 102.8604 cm 0 0 m 0 0 l 0 -11.339 l 42.52 -11.339 l 42.52 0 l h f Q BT 0 0 0 0 k /T1_2 1 Tf 9 0 0 9 73.5728 93.9331 Tm (ABSTRACT)Tj 1 0.68 0 0.12 k /T1_1 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\205)10(\210\036\033 \035\030\032\204\033)30(\021)42(\032)-21(\211\033\237)]TJ 57.136 0 Td (REVIEW)Tj -57.136 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 23, \023\0222, 202)69(4)]TJ 42.99 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 23, \023\0222, 202)69(4)]TJ /T1_4 1 Tf 25 0 0 25 20.8778 56.0378 Tm (184)Tj ET q 0 g 0 G 0 j 0 J /Fm1 Do Q 0 0 0 0 k 396.85 725.67 59.155 11.338 re f /PlacedPDF /MC0 BDC q 397.481 736.808 m 397.242 736.808 397.049 736.616 397.049 736.376 c 397.049 736.376 l 397.049 726.285 l 397.049 726.045 397.242 725.853 397.481 725.853 c 397.481 725.853 l 455.382 725.853 l 455.62 725.853 455.815 726.045 455.815 726.285 c 455.815 726.285 l 455.815 736.376 l 455.815 736.616 455.62 736.808 455.382 736.808 c 455.382 736.808 l h W n q 0 g -0.0000005 -10.9560913 -10.9560913 0.0000005 426.4320445 736.8086309 cm BX /Sh0 sh EX Q Q q 396.85 725.67 59.155 11.337 re W n 0 0 0 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T)46.5(her)-33.4(apeut)-32.5(ic dr)-22.4(ug moni)-24.4(t)16.5(or)]TJ 0 Tc 0 Tw 25.432 0 Td (-)Tj 0.016 Tc 0.592 Tw -27.286 -1.25 Td [(ing in p)31.7(a)14.8(t)-32.2(ients on biol)29.8(o)-16.3(gics: lessons fr)-32.3(om gastr)-32.2(oenter)-32.2(ol)]TJ 0 Tc 0 Tw (-)Tj 0.009 Tc -0.009 Tw T* [(o)-15.6(g)16.4(y. )]TJ /T1_1 1 Tf 0.349 Tw 2.366 0 Td [(Cur)-15.6(r Opin Rheumatol)]TJ /T1_0 1 Tf [(. 2020;32$4$:371\226379. d)-15.6(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs -0.009 Tw (10.1097/)Tj 0 Tc 0 Tw -2.366 -1.25 Td (BOR.0000000000000713)Tj 0 0 0 1 k /GS1 gs 0.015 Tc 0.53 Tw T* [(4)0.5(5)0.5(.)]TJ /Span<>> BDC 1.339 0 Td ( )Tj EMC 0.514 0 Td [(\215)0.5(\036)0.5(\007)0.6(\026)]TJ /Span<>> BDC 2.084 0 Td ( )Tj EMC [(\213)0.6(.)0.5(\225)0.5(.)0.5(,)0.6( \202)0.5(\035)0.5(\036)0.6(\022)0.5(\f)0.5(\026)0.5(\027)0.6(\007)0.5(\030)0.5(\024)0.5(\r)]TJ /Span<>> BDC 8.853 0 Td ( )Tj EMC [(\231)0.5(.)0.6(\214)0.5(.)0.5(,)0.6( \207)0.5(\026)0.5(\030)0.5(\026)0.6(\027)0.5(\024)0.5(\r)0.5(\026)]TJ /Span<>> BDC 7.495 0 Td ( )Tj EMC [(\231)0.5(.)0.6(\202)0.5(.)0.5(,)0.6( \017)]TJ /Span<>> BDC 3.952 0 Td ( )Tj EMC [(\f)0.5(\024)0.6(\026)0.5(\r)0.5(\021)0.5(.)15( )]TJ 0 Tc 0.251 Tw -24.238 -1.25 Td (\230\235\235\036\022\021\017\r\027\024\f\021\034 \017)Tj /Span<>> BDC ( )Tj EMC (\002\036\024\023\026\f\027\024\f\021\034 \023\036\030\036\b\024\007\026\ \f)Tj /Span<>> BDC ( )Tj EMC (\021\036\030\026\023\017\017 \024\030\017\020\017\027\026\035\034)Tj 0 Tw (-)Tj 0.276 Tw T* (\027\t\n\017 \023\030\036\023\026\030\026\021\026\n\017 \027\026)Tj /Span<>> BDC ( )Tj EMC (\002\017\024\f\017\n\017\035\016\030\t \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\035\036\004\036\027\017\017 \r\024\f\023\026\035\017\021\036\035\034)Tj 0 Tw (-)Tj 0.157 Tw T* (\027\t\b \026\002\024\035\036\r\026\027\017\005 \022\017\001\036\004\027\ \017\022\026. )Tj /T1_1 1 Tf (\212\021\024\f\016\033\022\003\016\020\035\037\027\215\020\037\030 \022)Tj /Span<>> BDC ( )Tj EMC (\021\027\022\020\022\201\016\024\021\037\030 )Tj 0.007 Tc -0.007 Tw T* (\013\037\024\035\033\034\204\020\035\016\033\034\027\034\013\022\030.)Tj /T1_0 1 Tf 0.349 Tw [( 2021;195$11$:35\22641. d)-15.7(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs -0.007 Tw (10.31146/1682-)Tj 0 Tc 0 Tw T* (8658-ecg195-11-35-41)Tj 0 0 0 1 k /GS1 gs 0.129 Tw [( )0.6(/ )0.6(P)30(ed)42(a)]TJ /Span<>> BDC ( )Tj EMC 12.708 0 Td [(E.S., )0.6(Ale)-18(x)-10.9(andr)-32(ov)]TJ /Span<>> BDC ( )Tj EMC 6.972 0 Td [(T.L., )0.6(Bar)-33(anov)-15(a)]TJ /Span<>> BDC ( )Tj EMC 6.166 0 Td (T.A., )Tj 0.001 Tc 0.349 Tw -25.846 -1.25 Td [(e)-11.8(t)]TJ /Span<>> BDC ( )Tj EMC [(al. T)47.2(he ef)-55.8(fec)-15.8(t)-31.8(i)-15.9(veness and safe)-11.8(t)-9.8(y of swi)-23.8(tching fr)-31.8(om t)-12.8(her)-32.8(apy)1( )]TJ 0 Tc 0.223 Tw T* [(wi)-24(t)-13(h or)-37(iginal dr)-22(ugs t)17(o biosimil)-15.9(ar)-10(s in t)-13(he tr)-23.9(ea)15(tment of infl)-16(amma)]TJ 0 Tw (-)Tj 0.003 Tc 0.35 Tw T* [(t)16.6(or)-24.4(y bo)-14.4(wel diseases. )]TJ /T1_1 1 Tf [(Exper)-37.4(imental and clinical g)11.5(astroenterology.)]TJ /T1_0 1 Tf 0 Tc 0 Tw 27.638 0 Td ( )Tj 0.14 Tw -27.638 -1.25 Td [(2021;195$11$:35\22641 $in Russ.$. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.31146/1682-8658-ecg195-)Tj T* (11-35-41)Tj 0 0 0 1 k /GS1 gs 0.007 Tw T* (46.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (\025\027\016\036\r)Tj /Span<>> BDC ( )Tj EMC (\210.\200., \003\r\016\020\035\024\r\026)Tj /Span<>> BDC ( )Tj EMC (\204.\222., \025\026\020\030\026\n\026\027\024\r\026)Tj /Span<>> BDC ( )Tj EMC (\202.\200., \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. \215\024\021\036\030\016 )Tj 0.223 Tw -1.796 -1.25 Td (\024\021\r\036\021\026 \017)Tj /Span<>> BDC ( )Tj EMC (\004\026\f\021\024\021\026 \027\036\032\036\035\026\021\036\035\034\027\t\ \b \016\r\035\036\027\017\005 \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\016\r\036\027)Tj 0 Tw (-)Tj 0.205 Tw T* (\027\t\n \022\024\035\017\021\024\n \017)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\036\027\034\033 \025\030\024\027\026 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\036\b\024\007\036 \f)Tj /Span<>> BDC ( )Tj EMC (\024\030\017\020\017\027\026\035\034\027\024\020\024 )Tj 0.227 Tw T* (\023\030\036\023\026\030\026\021\026 \017\027\235\035\017\022\f\017\n\026\ \002 \027\026)Tj /Span<>> BDC ( )Tj EMC (\036\020\024 \002\017\024\f\017\n\017\035\016\030\t. )Tj /T1_1 1 Tf 0 Tw (\205\016\033\037\f\016\036\035\022\201\016\024\021\022\b )Tj T* (\037\033\022\036.)Tj /T1_0 1 Tf 0.132 Tw [( 2021;93$2$:150\226157. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.26442/00403660.2021.02.200)Tj T* (624)Tj 0 0 0 1 k /GS1 gs 0.004 Tw [( )0.5(/ )0.6(Kny)22(a)-24(zev)]TJ /Span<>> BDC ( )Tj EMC 5.929 0 Td [(O.V., )0.6(Z)15(v)-17(y)22(a)-17(gl)30(ov)-15(a)]TJ /Span<>> BDC ( )Tj EMC 6.25 0 Td [(M.Y)35(u., )0.6(K)-16(a)-17(gr)-33(amanov)-15(a)]TJ /Span<>> BDC ( )Tj EMC 8.331 0 Td [(A.V., )0.6(e)-12(t)]TJ /Span<>> BDC ( )Tj EMC 3.135 0 Td [(al. )0.5(L)35(oss )0.6(of )]TJ 0 Tw -23.645 -1.25 Td [(r)-24(esponse and fr)-24(equency of ad)-17(ver)-9.9(se events in p)32(a)15(t)-32(ients wi)-24(t)-13(h ul)16(cer)-32.9(a)14.9(t)-31.9(i)-16(ve )]TJ 0.144 Tw T* [(col)-31(i)-23.9(t)-32(is and Cr)-32(ohn\254s disease when swi)-24(tching fr)-31.9(om t)-13(he or)-37(iginal dr)-21.9(ug )]TJ 0.162 Tw T* [(infl)-31(iximab )0.5(t)17.1(o i)-23.9(ts biosimil)-15.9(ar)-10(s. )]TJ /T1_1 1 Tf 12.241 0 Td [(Therapeutic )0.6(Archiv)13(e.)]TJ /T1_0 1 Tf [( )0.5(2021;93$2$:150\226)]TJ 0.023 Tw -12.241 -1.25 Td [(157. $in Russ.$. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.26442/00403660.2021.02.200624)Tj 0 0 0 1 k /GS1 gs 0.203 Tw T* (47.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Hanzel)Tj /Span<>> BDC ( )Tj EMC (J, Jansen)Tj /Span<>> BDC ( )Tj EMC [(JM, T)40(erS)15(teege)]TJ /Span<>> BDC ( )Tj EMC [(RWF, e)-11.9(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Mul)56(t)-32(iple Swi)-24(tches )]TJ 0.114 Tw -1.796 -1.25 Td [(F)10(r)-32(om t)-13(he Or)-37(igina)15(t)17(or Infl)-31(iximab t)17(o Biosimil)-15.9(ar)-10(s Is Ef)-55.9(fec)-16(t)-32(i)-16(ve and Safe )]TJ 0.21 Tw T* [(in Infl)-15.9(amma)15(t)17(or)-24(y Bo)-14(wel Disease: A P)35(r)-32(ospec)-16(t)-32(i)-16(ve Mul)56(t)-32(icenter Cohor)-22(t )]TJ 0 Tw T* [(S)15(tud)17(y. )]TJ /T1_1 1 Tf 0.134 Tw 2.909 0 Td [(Inf)-22(lamm Bow)12.1(el Dis.)]TJ /T1_0 1 Tf [( 2022;28$4$:495\226501. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1093/ibd/)Tj -2.909 -1.25 Td (izab099)Tj 0 0 0 1 k /GS1 gs 0.259 Tw T* (48.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Cohen)Tj /Span<>> BDC ( )Tj EMC [(HP, Bl)-16(auvel)56.1(t)]TJ /Span<>> BDC ( )Tj EMC [(A, R)-24(ifk)-16(in)]TJ /Span<>> BDC ( )Tj EMC [(RM, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Swi)-23.9(tching R)13(efer)-24(ence )]TJ 0.065 Tw -1.796 -1.25 Td [(Medic)-24(ines t)17.1(o Biosimil)-15.9(ar)-10(s: A Sy)-12.9(stema)15(t)-32(ic L)-32(i)-24(ter)-32.9(a)15(tur)-24(e R)13(ev)-16(iew of Cl)-31(inical )]TJ 0 Tw T* (Outcomes. )Tj /T1_1 1 Tf 4.682 0 Td (Drugs.)Tj /T1_0 1 Tf 0.214 Tw [( )0.5(2018;78$4$:463\226478. )0.6(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw 14.123 0 Td (10.1007/s40265-018-)Tj -18.806 -1.25 Td (0881-y)Tj 0 0 0 1 k /GS1 gs 0.036 Tw T* (49.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Y)30(e)]TJ /Span<>> BDC ( )Tj EMC [(BD, P)30.1(esegov)-15(a)]TJ /Span<>> BDC ( )Tj EMC [(M, Ale)-17.9(x)12(eev)-15(a)]TJ /Span<>> BDC ( )Tj EMC [(O, e)-11.9(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Ef)-56(f)-27.9(ica)-17(cy and safe)-11.9(t)-10(y of bio)]TJ 0 Tw (-)Tj 0.065 Tw -1.796 -1.25 Td [(simil)-15.9(ar CT-P13 com)10(p)32(ar)-24(ed wi)-23.9(t)-13(h or)-37(igina)15(t)17(or infl)-30.9(iximab in p)32(a)15(t)-32(ients wi)-24(t)-13(h )]TJ 0.131 Tw T* [(a)-17(c)-16(t)-32(i)-16(ve Cr)-32(ohn\254s disease: an inter)-14.9(na)15(t)-32(ional, r)-32.9(and)-16(omised, d)-16(ouble-bl)-30.9(ind, )]TJ 0.003 Tw T* [(phase 3 non-infer)-37(ior)-36.9(i)-24(t)-10(y stud)17(y. )]TJ /T1_1 1 Tf 0 Tw (Lancet)Tj /T1_0 1 Tf 0.003 Tw (. 2019;393$10182$:1699\2261707. )Tj 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1016/S0140-6736$18$32196-2)Tj 0 0 0 1 k /GS1 gs 0.192 Tw -1.847 -1.25 Td (50.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(S)15(tr)-37(ik)]TJ /Span<>> BDC ( )Tj EMC [(A)35(S, v)-15(an de V)16(r)-37(ie)]TJ /Span<>> BDC ( )Tj EMC [(W, Bl)30.1(oemsaa)15(t-Minekus)]TJ /Span<>> BDC ( )Tj EMC [(JP)35(J, e)-11.9(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Ser)-22(um )]TJ -0.001 Tw -1.796 -1.25 Td [(concentr)-33(a)15(t)-31.9(ions af)-27.9(ter swi)-24(tching fr)-32(om or)-37(igina)15(t)17(or infl)-31(iximab t)17(o t)-12.9(he bio)]TJ 0 Tw (-)Tj -0.032 Tw T* [(simil)-15.9(ar CT-P13 in p)32(a)15(t)-32(ients wi)-23.9(t)-13(h quiescent infl)-16(amma)15.1(t)17(or)-24(y bo)-14(wel disease )]TJ 0.101 Tw T* [($SECURE$: an open-l)-16(abel, mul)56(t)-32(icentr)-23.9(e, phase 4 non-infer)-37(ior)-36.9(i)-24(t)-10(y tr)-36.9(ial. )]TJ 0 Tw T* [(L)-32(ance)-12(t )]TJ /T1_1 1 Tf 0.324 Tw 3.283 0 Td (Gastroenterol Hepatol)Tj /T1_0 1 Tf [(. 2018;3$6$:404\226412. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1016/)Tj -3.283 -1.25 Td (S2468-1253$18$30082-7)Tj 0 0 0 1 k /GS1 gs 0.229 Tw T* (51.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Nar)-22(ul)-15.9(a)]TJ /Span<>> BDC ( )Tj EMC [(N, Mar)-10(shall)]TJ /Span<>> BDC ( )Tj EMC [(JK, Col)30(ombel)]TJ /Span<>> BDC ( )Tj EMC [(JF, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Sy)-13(stema)15(t)-31.9(ic R)13(ev)-16(iew )]TJ 0.092 Tw -1.796 -1.25 Td [(and Me)-12(t)15.1(a-Anal)35(y)-13(sis: Infl)-31(iximab or Cycl)30(ospor)-36.9(ine as R)13(escue T)47(her)-33(apy in )]TJ 0.07 Tw T* [(P)40(a)15(t)-32(ients W)-16(i)-24(t)-12.9(h Sever)-23.9(e Ul)16(cer)-32.9(a)15(t)-32(i)-16(ve Col)-31(i)-24(t)-32(is R)13(efr)-33(a)-17(c)-16(t)17(or)-23.9(y t)17(o S)15(ter)-32(oids. )]TJ /T1_1 1 Tf (Am J )Tj 0 Tw T* (Gastroenterol)Tj /T1_0 1 Tf 0.023 Tw [(. 2016;111$4$:477\22691. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1038/ajg.2016.7)Tj 0 0 0 1 k /GS1 gs 0.011 Tc 0.399 Tw T* (52.)Tj /Span<>> BDC ( )Tj EMC 1.839 0 Td (\215\024\007\024\035\034\f\022\026\016)Tj /Span<>> BDC ( )Tj EMC (\212.\200., \221\026\023\017\027\026)Tj /Span<>> BDC ( )Tj EMC (\204.\200., \207\026\030\026\027\024\r\026)Tj /Span<>> BDC ( )Tj EMC (\231.\202., \017)Tj /Span<>> BDC ( )Tj EMC [(\f\024\026\r\021.)11( )]TJ 0.015 Tc 0.559 Tw -1.839 -1.25 Td (\230\235\235\036\022\021\017\r\027\024\f\021\034 \021\024\235\026\006\017\ \021\017\027\017\002\026 \r)Tj /Span<>> BDC ( )Tj EMC (\022\026\004\036\f\021\r\036 \253\021\036\030\026\023\017\017 \f\023\026\ \f\036)Tj 0 Tc 0 Tw (-)Tj 0.014 Tc 0.515 Tw T* (\027\017\016\273 \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC [(\016\r\036\027\027\t\n \022\024\035\017\021\024\n \021\016\032\036\035\024\ \005 \f\021\036\023\036\027\017.)14( )]TJ /T1_1 1 Tf 0 Tc 0 Tw T* (\r\034\027\034\f\033\034\021\035\034\027\034\013\022\030)Tj /T1_0 1 Tf 0.321 Tw [(. 2021;20$3$:43\22650. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.33878/2073-7556-)Tj T* (2021-20-3-43-50)Tj 0 0 0 1 k /GS1 gs 0.234 Tw [( / P)10(od)-16(olsk)-16.9(a)15(y)22(a)]TJ /Span<>> BDC ( )Tj EMC [(D.V., S)-16(hapina)]TJ /Span<>> BDC ( )Tj EMC [(M.V., Bar)-32.9(anov)-15(a)]TJ /Span<>> BDC ( )Tj EMC (T.A., )Tj -0.065 Tw 29.055 81.25 Td [(e)-12(t)]TJ /Span<>> BDC ( )Tj EMC 0.998 0 Td [(al. )0.6(T)47(he )0.5(ef)-56(fec)-16(t)-32(i)-16(veness )0.5(of )0.5(t)17(of)16(a)-16.9(c)-24(i)-24(t)-32(inib )0.6(as )0.5(a )0.5(\236r)-24(escue )0.6(t)-13(her)-33(apy\237 )0.6(in )0.5(p)32(a)15(t)-32(ients )]TJ -0.016 Tw -0.998 -1.25 Td [(wi)-24(t)-12.9(h sever)-23.9(e ul)16(cer)-32.9(a)15(t)-32(i)-16(ve col)-31(i)-24(t)-32(is. )]TJ /T1_1 1 Tf 0 Tw [(K)18(olop)46(roktologia)]TJ /T1_0 1 Tf -0.016 Tw (. 2021;20$3$:43\22650 $in )Tj 0.023 Tw T* [(Russ.$. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.33878/2073-7556-2021-20-3-43-50)Tj 0 0 0 1 k /GS1 gs 0.331 Tw T* (53.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(S)-16(ingh)]TJ /Span<>> BDC ( )Tj EMC [(S, Mur)-33(ad)]TJ /Span<>> BDC ( )Tj EMC [(MH, F)10(umer)-24(y)]TJ /Span<>> BDC ( )Tj EMC [(M, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Com)10(p)32(ar)-32.9(a)15(t)-32(i)-16(ve ef)-56(f)-28(ica)-17(cy )]TJ 0.321 Tw -1.796 -1.25 Td [(and safe)-12(t)-10(y of biol)30(o)-16(gic t)-13(her)-32.9(apies for moder)-32.9(a)15(te-t)17(o-sever)-23.9(e Cr)-32(ohn\254s )]TJ 0.303 Tw T* [(disease: a sy)-13(stema)15.1(t)-32(ic r)-24(ev)-16(iew and ne)-12(t)-32(w)-14(or)-23.9(k me)-11.9(t)15(a-anal)35(y)-13(sis. )]TJ /T1_1 1 Tf 0 Tw (Lancet )Tj 0.066 Tw T* (Gastroenterol Hepatol.)Tj /T1_0 1 Tf [( 2021;6$12$:1002\2261014. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1016/S2468-)Tj T* (1253$21$00312-5)Tj 0 0 0 1 k /GS1 gs 0.069 Tw T* (54.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(S)-16(ingh)]TJ /Span<>> BDC ( )Tj EMC [(S, P)35(r)-32(o)-16(c)-16(t)17(or)]TJ /Span<>> BDC ( )Tj EMC [(D, S)-24(co)17(t)-30(t)]TJ /Span<>> BDC ( )Tj EMC [(FI, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. A)16(GA T)40(echnical R)13(ev)-16(iew on t)-13(he )]TJ 0.193 Tw -1.796 -1.25 Td [(Medical Mana)-17(gement of M)-23.9(oder)-33(a)15(te t)17(o Sever)-24(e L)35(uminal and P)30(er)-37(ianal )]TJ 0.341 Tw T* [(F)-19(istul)-30.9(izing Cr)-32(ohn\254s Disease. )]TJ /T1_1 1 Tf 0 Tw (Gastroenterology)Tj /T1_0 1 Tf 0.341 Tw (. 2021;160$7$:2512\226)Tj 0.023 Tw T* [(2556.e9. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw [(10.1053/j.gastr)-32(o.2021.04.023)]TJ 0 0 0 1 k /GS1 gs 0.339 Tw T* (55.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(S)-16(ingh)]TJ /Span<>> BDC ( )Tj EMC [(S, F)10(umer)-23.9(y)]TJ /Span<>> BDC ( )Tj EMC [(M, Sandbor)-15(n)]TJ /Span<>> BDC ( )Tj EMC [(W)31(J, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Sy)-13(stema)15.1(t)-32(ic r)-24(ev)-16(iew )]TJ 0.198 Tw -1.796 -1.25 Td [(and ne)-12(t)-32(w)-14(or)-24(k me)-12(t)15.1(a-anal)35(y)-13(sis: f)-28(ir)-10(st- and second-l)-31(ine biol)30(o)-16(gic t)-12.9(her)-33(a)]TJ 0 Tw (-)Tj 0.165 Tw T* [(pies for moder)-32.9(a)15(te-sever)-24(e Cr)-31.9(ohn\254s disease. )]TJ /T1_1 1 Tf [(Aliment Phar)-13.9(macol Ther.)]TJ /T1_0 1 Tf 0 Tw ( )Tj 0.023 Tw T* [(2018;48$4$:394\226409. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1111/apt.14852)Tj 0 0 0 1 k /GS1 gs 0.234 Tw T* (56.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(V)18(uyyur)-21.9(u)]TJ /Span<>> BDC ( )Tj EMC [(SK, K)-16(ante)]TJ /Span<>> BDC ( )Tj EMC [(B, K)25(umar)]TJ /Span<>> BDC ( )Tj EMC [(P, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. R)13(eal w)-13.9(or)-30(ld anal)35(y)-13(sis on )]TJ 0.24 Tw -1.796 -1.25 Td [(t)-13(he ef)-56(f)-28(ica)-16.9(cy and safe)-12(t)-10(y of ant)-32(i-tumor necr)-32(osis f)16(a)-17(c)-16(t)17(or t)-13(her)-32.9(apy in )]TJ -0.016 Tw T* [(p)32(a)15(t)-32(ients wi)-24(t)-13(h str)-37(ic)-16(tur)-36.9(ing Cr)-32(ohn\254s disease. )]TJ /T1_1 1 Tf [(Sci R)21(ep)]TJ /T1_0 1 Tf (. 2021;11$1$:11704. )Tj 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1038/s41598-021-90660-2)Tj 0 0 0 1 k /GS1 gs -0.016 Tw -1.847 -1.25 Td (57.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(L)35(u)]TJ /Span<>> BDC ( )Tj EMC [(C, Bar)-32.9(a)15(t)-10(y)]TJ /Span<>> BDC ( )Tj EMC [(B, L)35(ee R)11(ober)-22(tson)]TJ /Span<>> BDC ( )Tj EMC [(H, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Sy)-13(stema)15.1(t)-32(ic r)-24(ev)-15.9(iew: medical )]TJ 0.075 Tw -1.796 -1.25 Td [(t)-13(her)-32.9(apy for f)-28(ibr)-32(ostenosing Cr)-32(ohn\254s disease. )]TJ /T1_1 1 Tf [(Aliment Phar)-14(macol Ther.)]TJ /T1_0 1 Tf 0 Tw ( )Tj 0.023 Tw T* [(2020;51$12$:1233\2261246. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1111/apt.15750)Tj 0 0 0 1 k /GS1 gs 0.143 Tw T* (58.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Hashash)Tj /Span<>> BDC ( )Tj EMC [(JG, M)-23.9(our)-33(ad)]TJ /Span<>> BDC ( )Tj EMC [(FH. P)10(osi)-24(t)-32(ioning biol)30(o)-16(gics in t)-12.9(he mana)-17(ge)]TJ 0 Tw (-)Tj 0.042 Tw -1.796 -1.25 Td [(ment of moder)-32.9(a)15(te t)17(o sever)-23.9(e Cr)-32(ohn\254s disease. )]TJ /T1_1 1 Tf [(Cur)-16(r Opin Gastroenterol.)]TJ /T1_0 1 Tf 0 Tw ( )Tj 0.023 Tw T* [(2021;37$4$:351\226356. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1097/MOG.0000000000000735)Tj 0 0 0 1 k /GS1 gs -0.041 Tw T* (59.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Bouguen)Tj /Span<>> BDC ( )Tj EMC [(G, Hugue)-11.9(t)]TJ /Span<>> BDC ( )Tj EMC [(A, Amio)17(t)]TJ /Span<>> BDC ( )Tj EMC [(A, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Ef)-56(f)-28(ica)-16.9(cy and Safe)-11.9(t)-10(y of T)60(umor )]TJ 0.295 Tw -1.796 -1.25 Td [(Necr)-32(osis )0.5(F)20(a)-17(c)-16(t)17(or Ant)15(a)-17(gonists )0.5(in T)50(r)-24(ea)15(tment of Inter)-14.9(nal F)-19(istul)-30.9(izing )]TJ 0.299 Tw T* [(Cr)-32(ohn\254s Disease. )]TJ /T1_1 1 Tf (Clin Gastroenterol Hepatol.)Tj /T1_0 1 Tf ( 2020;18$3$:628\226636. )Tj 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1016/j.cgh.2019.05.027)Tj 0 0 0 1 k /GS1 gs 0.056 Tw -1.847 -1.25 Td (60.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(L)35(ee)]TJ /Span<>> BDC ( )Tj EMC [(MJ, P)40(ar)-24(k)10(er)]TJ /Span<>> BDC ( )Tj EMC [(CE, T)40(a)15(yl)30(or)]TJ /Span<>> BDC ( )Tj EMC [(SR, e)-11.9(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Ef)-55.9(f)-28(ica)-17(cy of Medical T)46.9(her)-32.9(apies )]TJ -0.014 Tw -1.796 -1.25 Td [(for F)-19(istul)-30.9(izing Cr)-32(ohn\254s Disease: Sy)-13(stema)15.1(t)-32(ic R)13(ev)-16(iew and Me)-12(t)15(a-anal)35(y)-13(sis. )]TJ /T1_1 1 Tf 0.064 Tw T* (Clin Gastroenterol Hepatol.)Tj /T1_0 1 Tf [( 2018;16$12$:1879\2261892. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1016/j.)Tj T* (cgh.2018.01.030)Tj 0 0 0 1 k /GS1 gs 0.043 Tw T* (61.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(S)15(tr)-37(ik)]TJ /Span<>> BDC ( )Tj EMC [(A)35(S, L\366wenber)-31.9(g)]TJ /Span<>> BDC ( )Tj EMC [(M, Busk)10.1(ens)]TJ /Span<>> BDC ( )Tj EMC [(CJ, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Higher ant)-32(i-TNF ser)-21.9(um )]TJ 0.047 Tw -1.796 -1.25 Td [(levels ar)-24(e asso)-15.9(c)-24(ia)15(ted wi)-24(t)-13(h per)-37(ianal f)-27.9(istul)-16(a cl)30(osur)-23.9(e in Cr)-32(ohn\254s disease )]TJ 0 Tw T* [(p)32(a)15(t)-32(ients. )]TJ /T1_1 1 Tf 0.049 Tw 3.886 0 Td (Scand J Gastroenterol. )Tj /T1_0 1 Tf [(2019;54$4$:453\226458. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1080/)Tj -3.886 -1.25 Td (00365521.2019.1600014)Tj 0 0 0 1 k /GS1 gs 0.19 Tw T* (62.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(T)40(and)-16(on)]TJ /Span<>> BDC ( )Tj EMC (P, Rhee)Tj /Span<>> BDC ( )Tj EMC [(GG, S)-24(chw)-11.9(ar)-22(tz)]TJ /Span<>> BDC ( )Tj EMC [(D, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. S)15(tr)-32.9(a)14.9(tegies t)17(o Opt)-32(imize )]TJ 0.123 Tw -1.796 -1.25 Td [(Ant)-32(i-tumor Necr)-32(osis F)20(a)-17(c)-16(t)17(or T)47(her)-33(apy for P)30(er)-37(ianal F)-19(istul)-30.9(izing Cr)-32(ohn\254s )]TJ 0.083 Tw T* [(Disease: A Sy)-13(stema)15(t)-32(ic )0.5(R)13(ev)-16(iew. )]TJ /T1_1 1 Tf [(Dig Dis )0.5(Sci)]TJ /T1_0 1 Tf (. 2019;64$11$:3066\2263077. )Tj 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1007/s10620-019-05635-1)Tj 0 0 0 1 k /GS1 gs 0.232 Tw -1.847 -1.25 Td (63.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Plevr)-36.9(is)]TJ /Span<>> BDC ( )Tj EMC [(N, Jenk)-16(inson)]TJ /Span<>> BDC ( )Tj EMC [(PW, Ar)-15(no)17(t)-30(t)]TJ /Span<>> BDC ( )Tj EMC [(ID, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Higher ant)-32(i-tumor )]TJ 0.184 Tw -1.796 -1.25 Td [(necr)-32(osis f)16(a)-17(c)-16(t)17(or levels ar)-23.9(e asso)-16(c)-24(ia)15(ted wi)-24(t)-13(h per)-36.9(ianal f)-28(istul)-15.9(a heal)-31(ing )]TJ 0.14 Tw T* [(and f)-28(istul)-16(a cl)30(osur)-24(e in Cr)-32(ohn\254s disease. )]TJ /T1_1 1 Tf (Eur J Gastroenterol Hepatol.)Tj /T1_0 1 Tf 0 Tw ( )Tj 0.023 Tw T* [(2020;32$1$:32\22637. d)-15.9(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1097/MEG.0000000000001561)Tj 0 0 0 1 k /GS1 gs 0.229 Tw T* (64.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(L)35(ewis)]TJ /Span<>> BDC ( )Tj EMC [(JD, S)-24(co)17(t)-30(t)]TJ /Span<>> BDC ( )Tj EMC [(FI, Br)-24(ensinger)]TJ /Span<>> BDC ( )Tj EMC [(CM, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Incr)-24(eased M)-24(or)-21.9(t)15(al)-31(i)-24(t)-10(y )]TJ 0.134 Tw -1.796 -1.25 Td [(R)-10(a)15(tes W)-16(i)-23.9(t)-13(h P)35(r)-32(ol)30(onged Cor)-22(t)-31.9(icoster)-32(oid T)47(her)-33(apy When Com)10(p)32(ar)-23.9(ed W)-16(i)-24(t)-13(h )]TJ 0.003 Tc 0.35 Tw T* [(Ant)-32(i)-24(tumor )0.5(Necr)-32(osis )0.5(F)20(a)-17.1(c)-16(t)17(or-\264-Dir)-24(ec)-16.1(ted )0.5(T)47(her)-33(apy )0.5(for )0.5(Infl)-16.1(amma)15(t)17(or)-24(y)3( )]TJ 0.018 Tc 0.663 Tw T* [(Bo)-14.3(wel Disease. )]TJ /T1_1 1 Tf (Am J Gastroenterol)Tj /T1_0 1 Tf [(. 2018;113$3$:405\226417.)18( )]TJ 0 Tc 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1038/ajg.2017.479)Tj 0 0 0 1 k /GS1 gs 0.061 Tw -1.847 -1.25 Td (65.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Nenc)-24(ini)]TJ /Span<>> BDC ( )Tj EMC [(F, V)18(ul)56(t)15.1(a)-17(ggio)]TJ /Span<>> BDC ( )Tj EMC [(A, P)35(r)-33(a)15(tesi)]TJ /Span<>> BDC ( )Tj EMC [(S, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. 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T)50(r)-32(ough level of infl)-31(iximab is )]TJ 0.103 Tw -1.796 -1.25 Td [(useful for assessing mucosal heal)-31(ing in Cr)-32(ohn\254s disease: a p)25(r)-31.9(ospec)]TJ 0 Tw (-)Tj 0.191 Tw T* [(t)-32(i)-16(ve cohor)-22(t stud)17(y. )]TJ /T1_2 1 Tf [(Intest R)21(es.)]TJ /T1_1 1 Tf [( 2018;16$2$:223\226232. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.5217/)Tj T* (ir.2018.16.2.223)Tj 0 0 0 1 k /GS1 gs 0.057 Tw T* (16.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Bl)-16(anchar)-23.9(d)]TJ /Span<>> BDC ( )Tj EMC [(F, W)12(ang)]TJ /Span<>> BDC ( )Tj EMC (Y, Kinzie)Tj /Span<>> BDC ( )Tj EMC [(E, e)-11.9(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Oncost)15(a)15(t)-32(in M r)-24(egul)-16(a)15(tes t)-12.9(he )]TJ 0.026 Tw -1.796 -1.25 Td [(synt)-13(hesis and tur)-15(nover of gp130, leuk)10(emia inhibi)-23.9(t)17(or)-24(y f)16(a)-17(c)-16(t)17(or r)-24(ecept)17(or )]TJ 0.008 Tw T* [(alpha, and oncost)15(a)15(t)-32(in M r)-24(ecept)17.1(or be)-12(t)15(a b)12(y dist)-32(inc)-16(t mechanis)26(ms. )]TJ /T1_2 1 Tf (J Biol )Tj 0 Tw T* (Chem.)Tj /T1_1 1 Tf 0.023 Tw [( 2001;276$50$:47038\22645. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1074/jbc.M107971200)Tj 0 0 0 1 k /GS1 gs 0.009 Tc 0.35 Tw T* (17.)Tj /Span<>> BDC ( )Tj EMC 1.833 0 Td (\025\030\031\004\017\027\017\027\026)Tj /Span<>> BDC ( )Tj EMC (\204.\200., \225\r\036\021\035\024\r\026)Tj /Span<>> BDC ( )Tj EMC (\224.\210., \210\f\017\023\036\027\022\024)Tj /Span<>> BDC ( )Tj EMC (\204.\205., \017)Tj /Span<>> BDC ( )Tj EMC [(\f\024\026\r\021.)9( )]TJ 0 Tc 0.129 Tw -1.833 -1.25 Td (\003\027\026\004\017\n\024\f\021\034 \031\030\024\r\027\036\005 \f\t\r\024\ \030\024\021\024\004\027\t\b \n\026\030\022\036\030\024\r \007\035\016 \024\ \006\036\027\022\017 \f\021\026\021\031\f\026 )Tj 0.228 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\020\027\024\026 \002\024\035\034\027\t\b \f)Tj /Span<>> BDC ( )Tj EMC (\r\024\f\023\026\035\017\021\036\035\034\027\t\n\017 \026\002\024\035\036\ \r\026\027\017\016\n\017 \022\017\001\036\004)Tj 0 Tw (-)Tj 0.009 Tc -0.009 Tw T* (\027\017\022\026. )Tj /T1_2 1 Tf 0.349 Tw 2.884 0 Td (\212\021\024\f\016\033\022\003\016\020\035\037\027\215\020\037\030 \022)Tj /Span<>> BDC ( )Tj EMC (\021\027\022\020\022\201\016\024\021\037\030 \013\037\024\035\033\034\204\ \020\035\016\033\034\027\034\013\022\030.)Tj /T1_1 1 Tf 0 Tc 0 Tw 24.754 0 Td ( )Tj 0.007 Tc 0.35 Tw -27.638 -1.25 Td [(2023;212$4$:121\226132. d)-16.4(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs -0.007 Tw (10.31146/1682-8658-ecg-212-4-121-)Tj 0 Tc 0 Tw T* (132)Tj 0 0 0 1 k /GS1 gs 0.128 Tw [( / Kr)-22(uchinina)]TJ /Span<>> BDC ( )Tj EMC [(M.V., Sve)-12(tl)30.1(ov)-15(a)]TJ /Span<>> BDC ( )Tj EMC (I.O., Osipenko)Tj /Span<>> BDC ( )Tj EMC [(M.F., e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. T)47(he sig)]TJ 0 Tw (-)Tj 0.092 Tw T* [(nif)-28(icance of ser)-21.9(um mar)-23.9(k)10(er levels for assessing t)-13(he st)15(a)15.1(tus and p)25(r)-32(o)-15.9(g)]TJ 0 Tw (-)Tj 0.21 Tw T* [(nosis of p)32(a)15(t)-32(ients wi)-24(t)-13(h infl)-16(amma)15(t)17(or)-23.9(y bo)-14(wel diseases. )]TJ /T1_2 1 Tf 0 Tw [(Exper)-37(imental )]TJ 0.01 Tc 0.372 Tw T* [(and clinical g)12(astroenterology)]TJ /T1_1 1 Tf [(. 2023;212$4$:121\226132 $in Russ.$.)10( )]TJ 0 Tc 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.31146/1682-8658-ecg-212-4-121-132)Tj 0 0 0 1 k /GS1 gs 0.25 Tw -1.847 -1.25 Td (18.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Ber)-22(t)15.1(ani)]TJ /Span<>> BDC ( )Tj EMC 3.43 0 Td [(L, )0.6(F)9.9(or)-14.9(nai)]TJ /Span<>> BDC ( )Tj EMC 4.101 0 Td [(M, )0.5(F)10(or)-14.9(nil)-31(i)]TJ /Span<>> BDC ( )Tj EMC 4.43 0 Td [(M, )0.5(e)-11.9(t)]TJ /Span<>> BDC ( )Tj EMC 2.648 0 Td [(al. )0.5(Ser)-21.9(um )0.5(oncost)15.1(a)15(t)-32(in )0.5(M )0.6(a)15(t )]TJ 0.066 Tw -16.405 -1.25 Td [(basel)-31(ine )0.5(p)25(r)-24(edic)-15.9(ts )0.5(mucosal )0.5(heal)-31(ing )0.5(in )0.5(Cr)-32(ohn\254s )0.5(disease )0.5(p)32(a)15(t)-32(ients )0.5(tr)-24(ea)15(t)]TJ 0 Tw (-)Tj 0.198 Tw T* [(ed wi)-24(t)-13(h infl)-30.9(iximab. )]TJ /T1_2 1 Tf [(Aliment Phar)-14(macol Ther.)]TJ /T1_1 1 Tf ( 2020;52$2$:284\226291. )Tj 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1111/apt.15870)Tj 0 0 0 1 k /GS1 gs 0.198 Tw -1.847 -1.25 Td (19.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(V)30(er)-10(st)17(o)-15.9(ck)-24(t)]TJ /Span<>> BDC ( )Tj EMC [(B, V)29.9(er)-9.9(st)17(o)-16(ck)-24(t)]TJ /Span<>> BDC ( )Tj EMC [(S, Dehair)-10(s)]TJ /Span<>> BDC ( )Tj EMC [(J, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. L)35(o)-14(w TREM1 e)-18(xp)25(r)-23.9(es)]TJ 0 Tw (-)Tj 0.276 Tw -1.796 -1.25 Td [(sion in whole bl)30(o)-16(od p)25(r)-24(edic)-16(ts ant)-32(i-TNF r)-24(esponse in infl)-15.9(amma)15(t)17(or)-24(y )]TJ 0.22 Tw T* [(bo)-14(wel disease)]TJ /T1_2 1 Tf [(. E Bio )0.5(Medicine.)]TJ /T1_1 1 Tf [( 2019;40:733\226742. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1016/j.)Tj T* (ebiom.2019.01.027)Tj 0 0 0 1 k /GS1 gs 0.255 Tw T* [(Andr)-24(eou)]TJ /Span<>> BDC ( )Tj EMC [(NP, L)35.1(egak)-16(i)]TJ /Span<>> BDC ( )Tj EMC [(E, Dovr)-32(ol)-31(is)]TJ /Span<>> BDC ( )Tj EMC [(N, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. B-cell a)-17(c)-15.9(t)-32(i)-16(v)-15(a)15(t)-32(ing f)16(a)-17(c)-16(t)17(or )]TJ 0.102 Tw T* [($BAFF$ e)-17.9(xp)25(r)-24(ession is asso)-15.9(c)-24(ia)15(ted wi)-24(t)-13(h Cr)-31.9(ohn\254s disease and can ser)-32(ve )]TJ 0.022 Tw T* [(as a po)17(tent)-32(ial p)25(r)-32(o)-16(gnost)-31.9(ic indica)15(t)17(or of disease r)-24(esponse t)17(o Infl)-30.9(iximab )]TJ 0 Tw T* [(tr)-24(ea)15(tment. )]TJ /T1_2 1 Tf 0.136 Tw 4.682 0 Td [(Dig Liv)13(er Dis)]TJ /T1_1 1 Tf [(. 2021 Ma)15(y;53$5$:574\226580. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1016/j.)Tj -4.682 -1.25 Td (dld.2020.11.030)Tj 0 0 0 1 k /GS1 gs 0.314 Tw T* (20.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Jahnsen)Tj /Span<>> BDC ( )Tj EMC [(J, K)-15.9(aasen J\370r)-32(gensen)]TJ /Span<>> BDC ( )Tj EMC [(K. E)35.1(xper)-37(ience wi)-23.9(t)-13(h Biosimil)-16(ar )]TJ 0.315 Tw -1.796 -1.25 Td [(Infl)-30.9(iximab $R)13(emsima\257$ in N)-14(or)-38(w)-12(a)15.1(y. )]TJ /T1_2 1 Tf (Dig Dis)Tj /T1_1 1 Tf (. 2017;35$1-2$:83\22690. )Tj 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1159/000449088.21)Tj 0 0 0 1 k /GS1 gs 0.278 Tw -1.847 -1.25 Td (21.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(L)35(ega)]TJ /Span<>> BDC ( )Tj EMC (S, Phan)Tj /Span<>> BDC ( )Tj EMC [(BL, R)11(osent)-13(hal)]TJ /Span<>> BDC ( )Tj EMC [(CJ, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. P)35(r)-31.9(oa)-17(c)-16(t)-32(i)-16(vel)35(y Opt)-31.9(imized )]TJ 0.134 Tw -1.796 -1.25 Td [(Infl)-30.9(iximab M)-24(ono)17(t)-12.9(her)-33(apy Is as Ef)-56(fec)-15.9(t)-32(i)-16(ve as Combina)15(t)-32(ion T)46.9(her)-32.9(apy in )]TJ 0 Tw T* (IBD. )Tj /T1_2 1 Tf 0.263 Tw 2.268 0 Td [(Inf)-22(lamm Bow)12(el Dis)]TJ /T1_1 1 Tf [(. 2019;25$1$:134\226141. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1093/ibd/)Tj -2.268 -1.25 Td (izy203)Tj 0 0 0 1 k /GS1 gs 0.037 Tw T* (22.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (D\254Haens)Tj /Span<>> BDC ( )Tj EMC [(G, )0.5(V)30(er)-16(meir)-23.9(e)]TJ /Span<>> BDC ( )Tj EMC [(S, L)-32(ambr)-23.9(echt)]TJ /Span<>> BDC ( )Tj EMC [(G, )0.5(e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Incr)-23.9(easing Infl)-30.9(iximab )]TJ -0.056 Tw -1.796 -1.25 Td [(Dose Based on Sym)10(pt)17(oms, Biomar)-23.9(k)10(er)-10(s, and Ser)-22(um Dr)-22(ug Concentr)-32.9(a)15(t)-32(ions )]TJ 0.003 Tc 0.349 Tw T* [(D)0.6(o)0.5(e)0.6(s)0.5( N)-13.4(o)17.5(t)0.6( I)0.6(n)0.5(c)0.6(r)-23.4(e)0.5(a)0.6(s)0.5(e)0.6( C)0.5(l)-30.4(i)0.6(n)0.5(i)0.6(c)0.5(a)0.6(l)0.5(,)0.6( E)0.6(n)0.6(d)-15.5(o)0.6(s)0.5(c)0.6(o)0.5(p)0.6(i)0.5(c)0.6(,)0.5( a)0.6(n)0.5(d)0.6( C)0.5(o)0.6(r)-21.5(t)-31.4(i)0.6(c)0.5(o)0.6(s)0.5(t)0.6(e)0.5(r)-31.4(o)0.5(i)0.6(d)0.5(-)0.6(F)10.5(r)-23.4(e)0.6(e)3( )]TJ 0.012 Tc 0.459 Tw T* [(R)12.6(emission )0.5(in )0.5(P)39.6(a)14.6(t)-32.4(ients )0.5(W)-16.4(i)-24.4(t)-13.4(h )0.5(A)-25.4(c)-16.4(t)-32.4(i)-16.4(ve )0.6(L)34.6(uminal )0.6(Cr)-32.4(ohn\254s )0.6(Disease.)12( )]TJ /T1_2 1 Tf 0 Tc 0 Tw T* (Gastroenterology)Tj /T1_1 1 Tf 0.31 Tw [(. 2018;154$5$:1343\2261351.e1. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1053/j.gas)Tj (-)Tj T* [(tr)-32(o.2018.01.004)]TJ 0 0 0 1 k /GS1 gs 0.022 Tw T* (23.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(P)40(ap)32(amichael)]TJ /Span<>> BDC ( )Tj EMC [(K, R)-10(ako)-14(wsk)-31.9(y)]TJ /Span<>> BDC ( )Tj EMC [(S, R)-24(i)-16(ver)-32.9(a)]TJ /Span<>> BDC ( )Tj EMC [(C, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Asso)-15.9(c)-24(ia)15(t)-32(ion Be)-12(t)-32(ween )]TJ 0.012 Tc 0.458 Tw -1.796 -1.25 Td [(Ser)-22.4(um Infl)-31.4(iximab T)49.6(r)-32.5(ough Concentr)-33.3(a)14.5(t)-32.4(ions Dur)-37.4(ing Maintenance)12( )]TJ 0.001 Tc 0.349 Tw T* [(T)47.4(h)0.5(er)-32.5(apy)0.5( and)0.5( B)0.5(io)-15.5(ch)0.5(emi)0.5(ca)0.5(l,)0.5( E)0.5(nd)-15.5(osc)0.5(opi)0.5(c,)0.5( a)0.5(nd H)0.5(ist)17.5(ol)30.5(o)-15.6(g)0.5(ic R)13.4(e)0.5(mi)0.5(ssi)0.5(on)1( )]TJ 0 Tc 0.312 Tw T* [(in Cr)-32(ohn\254s Disease. )]TJ /T1_2 1 Tf [(Inf)-21.9(lamm Bow)12.1(el Dis.)]TJ /T1_1 1 Tf ( 2018;24$10$:2266\2262271. )Tj 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1093/ibd/izy132)Tj 0 0 0 1 k /GS1 gs 0.09 Tw -1.847 -1.25 Td (24.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(F)10(er)-15(nandes)]TJ /Span<>> BDC ( )Tj EMC 4.393 0 Td [(SR, Ber)-14.9(nar)-24(d)-16(o)]TJ /Span<>> BDC ( )Tj EMC [(S, S)-15.9(im\365es)]TJ /Span<>> BDC ( )Tj EMC [(C, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC 11.756 0 Td [(al. P)35(r)-31.9(oa)-17(c)-16(t)-32(i)-16(ve Infl)-30.9(iximab )]TJ 0.011 Tc 0.391 Tw -17.945 -1.25 Td [(D)0.5(r)-21.5(u)0.5(g)0.5( M)-23.4(on)0.5(i)-23.5(t)17.5(o)0.5(r)-36.5(i)0.5(ng)0.5( I)0.5(s)0.5( S)0.5(u)0.5(pe)0.5(r)-36.5(i)0.5(o)0.5(r)0.5( t)17.5(o C)0.5(o)0.5(n)0.5(v)0.5(en)0.5(t)-31.5(i)0.5(o)0.5(n)0.5(al)0.5( M)0.5(a)0.5(n)0.5(a)-16.5(ge)0.5(m)0.5(e)0.5(n)0.5(t)0.5( i)0.5(n)11.1( )]TJ 0 Tc 0.17 Tw T* [(Infl)-15.9(amma)15(t)17(or)-24(y Bo)-13.9(wel Disease. )]TJ /T1_2 1 Tf [(Inf)-22(lamm Bow)12(el Dis)]TJ /T1_1 1 Tf (. 2020;26$2$:263\226)Tj 0.023 Tw T* [(270. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw [(10.1093/ibd/iz)-24(z131)]TJ 0 0 0 1 k /GS1 gs 0.092 Tw T* (25.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(F)10(er)-15(nandes)]TJ /Span<>> BDC ( )Tj EMC 4.395 0 Td [(SR, Ser)-23.9(r)-33(a)-24(zina)]TJ /Span<>> BDC ( )Tj EMC [(J, )0.5(R)11(odr)-37(igues)]TJ /Span<>> BDC ( )Tj EMC [(IC, )0.5(e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. P)35(r)-32(oa)-16.9(c)-16(t)-32(i)-16(ve t)-13(her)-32.9(a)]TJ 0 Tw (-)Tj 0.154 Tw -6.191 -1.25 Td [(peut)-32(ic dr)-21.9(ug moni)-24(t)17(or)-36.9(ing is mor)-24(e ef)-56(fec)-15.9(t)-32(i)-16(ve t)-13(han convent)-32(ional man)]TJ 0 Tw (-)Tj 0.175 Tw T* [(a)-17(gement in induc)-23.9(ing fecal calp)25(r)-32(o)17(tec)-16(t)-31.9(in r)-24(emission in infl)-15.9(amma)15(t)17(or)-24(y )]TJ 0.016 Tw T* [(bo)-14(wel disease. )]TJ /T1_2 1 Tf (Eur J Gastroenterol Hepatol.)Tj /T1_1 1 Tf ( 2021;33$12$:1539\2261546. )Tj 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1097/MEG.0000000000002111)Tj 0 0 0 1 k /GS1 gs 0.296 Tw -1.847 -1.25 Td (26.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(R)-24(icc)-24(iut)17.1(o)]TJ /Span<>> BDC ( )Tj EMC [(A, Dhal)-31(iw)-12(al)]TJ /Span<>> BDC ( )Tj EMC [(J, W)12(al)56(ter)-9.9(s)]TJ /Span<>> BDC ( )Tj EMC [(TD, e)-11.9(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Cl)-31(inical Outcomes )]TJ 0.016 Tc 0.598 Tw -1.796 -1.25 Td [(W)-16.4(i)-24.4(t)-13.4(h T)46.5(her)-33.3(apeut)-32.4(ic Dr)-22.4(ug M)-24.4(oni)-24.4(t)16.6(or)-37.4(ing in Infl)-16.3(amma)14.5(t)16.6(or)-24.3(y Bo)-14.4(wel)16( )]TJ 0 Tc 0.15 Tw T* [(Disease: A Sy)-13(stema)15(t)-32(ic R)13(ev)-16(iew W)-16(i)-23.9(t)-13(h Me)-12(t)15(a-Anal)35(y)-13(sis. )]TJ /T1_2 1 Tf (J Crohns Colitis)Tj /T1_1 1 Tf 0 Tw (. )Tj 0.023 Tw T* [(2018;12$11$:1302\2261315. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1093/ecco-jcc/jjy109)Tj 0 0 0 1 k /GS1 gs 0.01 Tc 0.357 Tw T* [(2)0.5(7.)]TJ /Span<>> BDC 1.325 0 Td ( )Tj EMC 0.51 0 Td [(P)40.4(a)0.5(p)32.5(am)0.5(ic)0.5(h)0.5(ae)0.5(l)]TJ /Span<>> BDC ( )Tj EMC [(K)0.5(, V)25.5(aj)0.5(r)-32.6(a)0.5(v)0.5(el)35.5(u)]TJ /Span<>> BDC ( )Tj EMC [(R)0.5(K,)0.5( V)25.4(a)0.5(ug)0.5(h)0.5(n)]TJ /Span<>> BDC ( )Tj EMC [(BP)0.5(,)0.5( e)-11.5(t)]TJ /Span<>> BDC 19.635 0 Td ( )Tj EMC [(al)0.5(.)0.5( P)35.5(r)-31.5(oa)-16.5(c)-15.6(t)-31.5(i)-15.5(ve)10( )]TJ 0 Tc 0.012 Tw 7.586 81.25 Td [(Infl)-30.9(iximab M)-23.9(oni)-24(t)17(or)-37(ing F)10(oll)30(o)-13.9(wing R)13(ea)-17(c)-16(t)-31.9(i)-16(ve T)40(est)-32(ing is Asso)-15.9(c)-24(ia)15(ted W)-16(i)-24(t)-12.9(h )]TJ 0.193 Tw T* [(Be)-12(t)-30(ter Cl)-31(inical Outcomes T)47(han R)13(ea)-17(c)-16(t)-32(i)-16(ve T)40(est)-32(ing Al)30(one in P)40(a)15(t)-32(ients )]TJ 0.043 Tw T* [(W)-16(i)-24(t)-12.9(h )0.5(Infl)-15.9(amma)15(t)17(or)-24(y )0.6(Bo)-14(wel )0.5(Disease)]TJ /T1_2 1 Tf [(. )0.5(J )0.6(Crohns )0.6(Colitis.)]TJ /T1_1 1 Tf [( )0.6(2018;12$7$:804\226)]TJ 0.023 Tw T* [(810. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1093/ecco-jcc/jjy039)Tj 0 0 0 1 k /GS1 gs 0.35 Tw T* (28.)Tj /Span<>> BDC ( )Tj EMC 1.797 0 Td [(Hose)-11.1(yni)]TJ /Span<>> BDC ( )Tj EMC (H, Xu)Tj /Span<>> BDC ( )Tj EMC (Y, Zhou)Tj /Span<>> BDC ( )Tj EMC [(H. )0.5(T)46.8(her)-33.2(apeut)-32.1(ic Dr)-22.1(ug M)-24.1(oni)-24.1(t)16.9(or)-37.1(ing of )]TJ 0.113 Tw -1.797 -1.25 Td [(Biol)30(o)-16(gics for Infl)-16(amma)15.1(t)17(or)-24(y Bo)-14(wel Disease: An Answer t)17(o Opt)-32(imized )]TJ 0 Tw T* [(T)50(r)-24(ea)15(tment? )]TJ /T1_2 1 Tf 0.229 Tw 4.963 0 Td [(J )0.5(Clin )0.5(Phar)-13.9(macol.)]TJ /T1_1 1 Tf [( )0.5(2018;58$7$:864\226876. )0.6(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw 18.935 0 Td (10.1002/)Tj -23.899 -1.25 Td (jcph.1084)Tj 0 0 0 1 k /GS1 gs 0.003 Tc 0.35 Tw T* (29.)Tj /Span<>> BDC ( )Tj EMC 1.809 0 Td [(L)-32.3(a)14.6(ter)-24.4(za)]TJ /Span<>> BDC ( )Tj EMC [(L, Ainor)-33.3(a)]TJ /Span<>> BDC ( )Tj EMC [(ME, Gar)-32.4(cov)-16.4(ich)]TJ /Span<>> BDC ( )Tj EMC [(M, e)-12.3(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Bo)-14.3(wel contr)-33.3(ast-)]TJ 0 Tc 0.04 Tw -1.809 -1.25 Td [(enhanced )0.5(ul)56(tr)-32.9(asound )0.5(per)-24(fusion )0.5(ima)-17(ging )0.5(in )0.5(t)-13(he )0.5(ev)-15(al)35(ua)15(t)-31.9(ion of )0.5(Cr)-32(ohn\254s )]TJ 0.009 Tc 0.35 Tw T* [(disease p)31.7(a)14.7(t)-32.3(ients under)-32.3(going ant)-32.3(i-TNF\264 t)-13.3(her)-33.3(apy. )]TJ /T1_2 1 Tf [(Dig Liv)12.6(er Dis.)]TJ /T1_1 1 Tf 0 Tc 0 Tw 27.638 0 Td ( )Tj 0.023 Tw -27.638 -1.25 Td [(2021;53$6$:729\226737. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1016/j.dld.2020.08.005)Tj 0 0 0 1 k /GS1 gs 0.318 Tw T* (30.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(T)40(ar)-32(go)-14(wnik)]TJ /Span<>> BDC ( )Tj EMC (LE, Benchimol)Tj /Span<>> BDC ( )Tj EMC [(EI, Ber)-15(nstein)]TJ /Span<>> BDC ( )Tj EMC [(CN, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC (al. Combined )Tj -0.008 Tw -1.796 -1.25 Td [(Biol)30(o)-16(gic and Immunomodul)-16(a)15(t)17(or)-23.9(y T)47.1(her)-33(apy is Super)-37(ior t)17.1(o M)-23.9(ono)17(t)-13(her)-33(apy )]TJ 0.339 Tw T* [(for Decr)-24(easing t)-12.9(he R)-23.9(isk of Infl)-16(amma)15(t)17(or)-23.9(y Bo)-13.9(wel Disease-R)13(el)-16(a)15(ted )]TJ 0.024 Tc -0.024 Tw T* [(Com)9.8(pl)-31.1(ica)14.9(t)-32.2(ions. )]TJ /T1_2 1 Tf 0.87 Tw 7.466 0 Td (J Crohns Colitis.)Tj /T1_1 1 Tf [( 2020;14$10$:1354\2261363.)24( )]TJ 0 Tc 0 Tw -7.466 -1.25 Td [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1093/ecco-jcc/jjaa050)Tj 0 0 0 1 k /GS1 gs 0.009 Tc 0.354 Tw -1.847 -1.25 Td (31.)Tj /Span<>> BDC ( )Tj EMC 1.834 0 Td [(T)39.6(ar)-32.5(go)-14.4(wnik)]TJ /Span<>> BDC ( )Tj EMC (LE, Benchimol)Tj /Span<>> BDC ( )Tj EMC [(EI, Ber)-15.4(nstein)]TJ /Span<>> BDC ( )Tj EMC [(CN, e)-12.4(t)]TJ /Span<>> BDC ( )Tj EMC [(al. U)12.6(pfr)-32.4(ont)9( )]TJ 0 Tc 0.339 Tw -1.834 -1.25 Td [(Combina)15(t)-32(ion )0.5(T)47(her)-32.9(apy, )0.5(Com)10(p)32(ar)-24(ed )0.5(W)-16(i)-24(t)-13(h )0.5(M)-24(ono)17(t)-13(her)-32.9(apy, )0.5(for )0.5(P)40(a)15(t)-32(ients )]TJ 0.004 Tc 0.35 Tw T* [(N)-14(o)17(t )0.6(P)35(r)-24(ev)-15.9(iousl)35(y )0.6(T)50(r)-24(ea)15(ted )0.5(W)-16(i)-23.9(t)-13(h )0.5(a )0.6(Biol)30.1(o)-16(gic )0.5(A)-24.9(gent )0.5(Asso)-16(c)-24(ia)15.1(tes )0.6(W)-16(i)-24(t)-13(h)4( )]TJ 0 Tc 0.095 Tw T* [(R)13(educed R)-24(isk of Infl)-16(amma)15(t)17(or)-23.9(y Bo)-13.9(wel Disease-r)-24(el)-15.9(a)15(ted Com)10(pl)-30.9(ica)15(t)-32(ions )]TJ 0.341 Tw T* [(in a P)10(opul)-15.9(a)15(t)-32(ion-based Cohor)-21.9(t S)15(tud)17(y. )]TJ /T1_2 1 Tf [(Clin )0.5(Gastroenterol )0.5(Hepatol.)]TJ /T1_1 1 Tf 0 Tw ( )Tj 0.023 Tw T* [(2019;17$9$:1788\2261798.e2. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1016/j.cgh.2018.11.003)Tj 0 0 0 1 k /GS1 gs 0.316 Tw T* (32.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(M)-24(o)-16(gensen)]TJ /Span<>> BDC ( )Tj EMC [(D)11(V, Br)-24(ynskov)]TJ /Span<>> BDC ( )Tj EMC [(J, Ainsw)-14(or)-22(t)-13(h)]TJ /Span<>> BDC ( )Tj EMC [(MA, e)-11.9(t)]TJ /Span<>> BDC ( )Tj EMC [(al. A R)11(ole for )]TJ 0.012 Tc 0.45 Tw -1.796 -1.25 Td [(T)46.8(hiopur)-37.2(ine Me)-12.2(t)14.8(abol)-31.2(i)-24.1(tes in t)-13.1(he Syner)-32.1(gis)25.8(m Be)-12.2(t)-32.2(ween)49.8(T)46.8(hiopur)-37.2(ines)12( )]TJ 0 Tc 0.301 Tw T* [(and Infl)-30.9(iximab in Infl)-16(amma)15(t)17(or)-23.9(y Bo)-14(wel Disease. )]TJ /T1_2 1 Tf (J Crohns Colitis)Tj /T1_1 1 Tf 0 Tw (. )Tj 0.023 Tw T* [(2018;12$3$:298\226305. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1093/ecco-jcc/jjx149)Tj 0 0 0 1 k /GS1 gs 0.011 Tc 0.401 Tw T* (33.)Tj /Span<>> BDC ( )Tj EMC 1.839 0 Td [(Col)30.2(ombel)]TJ /Span<>> BDC ( )Tj EMC [(JF, A)15.3(ded)-15.8(okun)]TJ /Span<>> BDC ( )Tj EMC (OJ, Gasink)Tj /Span<>> BDC ( )Tj EMC [(C, e)-11.7(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Combina)15.2(t)-31.8(ion)11( )]TJ 0.005 Tc 0.35 Tw -1.839 -1.25 Td [(T)46.6(her)-33.4(apy W)-16.4(i)-24.3(t)-13.4(h Infl)-31.3(iximab and A)-24.3(za)14.7(t)-13.4(hiop)24.6(r)-37.3(ine Im)9.6(p)24.6(r)-32.4(oves Infl)-31.3(iximab)5( )]TJ 0 Tc 0.205 Tw T* [(Phar)-16(ma)-16.9(cok)-16(ine)-12(t)-32(ic F)10(ea)15(tur)-23.9(es and Ef)-56(f)-28(ica)-16.9(cy: A P)10(ost Ho)-16(c Anal)35(y)-12.9(sis. )]TJ /T1_2 1 Tf 0 Tw (Clin )Tj 0.31 Tw T* (Gastroenterol Hepatol.)Tj /T1_1 1 Tf [( 2019;17$8$:1525\2261532.e1. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1016/j.)Tj T* (cgh.2018.09.033)Tj 0 0 0 1 k /GS1 gs 0.148 Tw T* (34.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Ma)15(t)-30(t)17(o)-16(o)]TJ /Span<>> BDC ( )Tj EMC [(VY, Basna)15(y)22(ak)10(e)]TJ /Span<>> BDC ( )Tj EMC (C, Connell)Tj /Span<>> BDC ( )Tj EMC [(WR, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Sy)-13(stema)15.1(t)-32(ic r)-24(ev)-16(iew: )]TJ -0.031 Tw -1.796 -1.25 Td [(ef)-56(f)-28(ica)-17(cy of escal)-15.9(a)15(ted maintenance ant)-32(i-tumour necr)-31.9(osis f)16(a)-17(c)-16(t)17(or t)-13(her)-32.9(a)]TJ 0 Tw (-)Tj 0.029 Tw T* [(py in Cr)-32(ohn\254s disease. )]TJ /T1_2 1 Tf [(Aliment Phar)-14(macol Ther.)]TJ /T1_1 1 Tf ( 2021;54$3$:249\226266. )Tj 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1111/apt.16479)Tj 0 0 0 1 k /GS1 gs 0.103 Tw -1.847 -1.25 Td (35.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Dr)-32(obne)]TJ /Span<>> BDC ( )Tj EMC [(D, K)25(ur)-24(ent)]TJ /Span<>> BDC ( )Tj EMC [(T, Gol)30.1(ob)]TJ /Span<>> BDC ( )Tj EMC [(S, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Opt)-32(imised infl)-31(iximab mono)]TJ 0 Tw (-)Tj 0.218 Tw -1.796 -1.25 Td [(t)-13(her)-32.9(apy is as )0.5(ef)-56(fec)-16(t)-32(i)-16(ve )0.5(as opt)-32(imised )0.5(combina)15(t)-32(ion )0.5(t)-13(her)-33(apy, )0.5(but is )]TJ -0.008 Tw T* [(asso)-16(c)-24(ia)15.1(ted wi)-24(t)-12.9(h higher dr)-22(ug consum)10(pt)-32(ion in infl)-16(amma)15(t)17.1(or)-24(y bo)-14(wel dis)]TJ 0 Tw (-)Tj T* (ease. )Tj /T1_2 1 Tf 0.158 Tw 2.472 0 Td [(Aliment Phar)-13.9(macol )0.5(Ther.)]TJ /T1_1 1 Tf [( )0.5(2019;49$7$:880\226889. )0.5(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw 21.426 0 Td (10.1111/)Tj -23.899 -1.25 Td (apt.15179)Tj 0 0 0 1 k /GS1 gs 0.011 Tc 0.403 Tw T* (36.)Tj /Span<>> BDC ( )Tj EMC 1.839 0 Td [(Sr)-36.8(ini)-15.9(v)-14.8(asan)]TJ /Span<>> BDC ( )Tj EMC [(A, V)25.2(asudev)-14.9(an)]TJ /Span<>> BDC ( )Tj EMC [(A, McF)20.2(ar)-29.9(l)-15.8(ane)]TJ /Span<>> BDC ( )Tj EMC [(A, e)-11.8(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Ant)-31.8(i-TNF)11.1( )]TJ 0 Tc 0.164 Tw -1.839 -1.25 Td [(R)13(e-induc)-16(t)-31.9(ion Is )0.5(as )0.5(Ef)-55.9(fec)-16(t)-32(i)-16(ve, )0.5(S)-16(im)10(pler, )0.5(and Cheaper )0.5(Com)10(p)32(ar)-23.9(ed )0.5(W)-16(i)-24(t)-13(h )]TJ 0.081 Tw T* [(Dose )0.6(Inter)-32(v)-15(al )0.6(S)-16(hor)-22(tening )0.6(for )0.5(Second)42(ar)-24(y )0.5(L)35(oss )0.6(of )0.5(R)13(esponse )0.6(in )0.5(Cr)-32(ohn\254s )]TJ 0 Tw T* (Disease. )Tj /T1_2 1 Tf 0.165 Tw 3.704 0 Td (J Crohns Colitis.)Tj /T1_1 1 Tf [( 2018;12$3$:280\226288. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1093/ecco-)Tj -3.704 -1.25 Td (jcc/jjx144)Tj 0 0 0 1 k /GS1 gs 0.138 Tw T* (37.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Dr)-32(obne)]TJ /Span<>> BDC ( )Tj EMC [(D, K)25(ur)-24(ent)]TJ /Span<>> BDC ( )Tj EMC [(T, Gol)30(ob)]TJ /Span<>> BDC ( )Tj EMC [(S, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Success and safe)-12(t)-10(y of high )]TJ 0.266 Tw -1.796 -1.25 Td [(infl)-30.9(iximab tr)-32(ough levels in infl)-15.9(amma)15(t)17(or)-24(y bo)-14(wel disease. )]TJ /T1_2 1 Tf (Scand J )Tj 0 Tw T* (Gastroenterol)Tj /T1_1 1 Tf 0.255 Tw [(. 2018;53$8$:940\226946. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1080/00365521.2018.)Tj T* (1486882)Tj 0 0 0 1 k /GS1 gs 0.063 Tw T* (38.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Syver)-9.9(sen)]TJ /Span<>> BDC ( )Tj EMC [(S)-9.9(W, J\370r)-32(gensen)]TJ /Span<>> BDC ( )Tj EMC (KK, Goll)Tj /Span<>> BDC ( )Tj EMC [(GL, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. 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[(\021\030\036\002\031\033\021 )0.5(\f\n\036\027\t )0.5(\021\036\030\026\023\017\017 \027\026)]TJ /Span<>> BDC ( )Tj EMC 13.911 0 Td [(\023\030\036\023\026\030\026\021\t )0.5(\007\030\031\020\024\020\024 )]TJ 0 Tw -13.911 -1.218 Td (\022\035\026\f\f\026.)Tj /T1_1 1 Tf 0.023 Tw 0 -2.436 TD (\223\030\032\255\020\034\036 \032\026\020\017\022\017\026)Tj /T1_0 1 Tf -0.026 Tw 0 -1.218 TD [(\025)-4.1(\024)-4.3(\027)1.7(\006)-6(\036)-6.8(\023)2.2(\006)-6(\017)-5.4(\016 \017)]TJ /Span<>> BDC ( )Tj EMC [(\007)-6(\017)2.7()-9.9(\026\005)1.7(\027 \017)-2.4(\f)3.1(\f)-38.9(\035)-6.8(\036)-19(\007)-4.4(\024)-4.3(\r)-8.8(\026\027)1.7(\017)-5.5(\016)13.7(:)]TJ /T1_2 1 Tf -0.003 Tc -0.023 Tw [( \223)-20.3(\027\016\021)6.3(\024)7.3(\037)1.3(\020)3.6(\004\033)-2.9(\034)6.6(\036)]TJ /Span<>> BDC 20.182 0 Td ( )Tj EMC [(\205)62(.)-10.8(\222)22(.)4.8(,)-3( )]TJ -0.01 Tc 0.01 Tw -20.182 -1.218 Td [(\206\032)0.7(\021\034\036)-7.9(\037)]TJ /Span<>> BDC 3.02 0 Td ( )Tj EMC [(\006)8.5(.)-2.7(\223)-12.2(.)]TJ /T1_0 1 Tf 0 Tc 0 Tw 20.224 29.227 Td [(\225)-4.6(\002)-9.9(\024)0.7(\030 \017)]TJ /Span<>> BDC ( )Tj EMC [(\024)-11.8(\002)3(\030)-11.3(\026)-6.4(\002)-9.9(\024)-10.8(\021)-17.7(\022)-19.1(\026 \n)1.3(\026)-11.8(\021)-9.9(\036)-1.7(\030)-7.6(\017)-0.6(\026)-33.1(\035\026)3.7(:)]TJ /T1_2 1 Tf -0.003 Tc 0.003 Tw [( \223)-20.3(\027\016\021)6.4(\024)7.3(\037)1.3(\020)3.6(\004\033)-2.9(\034)6.6(\036)]TJ /Span<>> BDC 17.647 0 Td ( )Tj EMC [(\205)62(.)-10.8(\222)22(.)]TJ /T1_0 1 Tf 0.002 Tc -0.002 Tw -17.647 -1.218 Td [(\203)7.2(\026\023)4.2(\017\f)-10.8(\026)1.7(\027)3.7(\017)-6.7(\036)2.1( \021)-7.9(\036)-3.4(\022\f)-34(\021)-19.5(\026)5.7(:)]TJ /T1_2 1 Tf -0.003 Tc 0.003 Tw 7.694 0 Td [( \223)-20.3(\027\016\021)6.3(\024)7.3(\037)1.3(\020)3.6(\004\033)-2.9(\034)6.6(\036)]TJ /Span<>> BDC 5.418 0 Td ( )Tj EMC [(\205)62(.)-10.8(\222)22(.)]TJ /T1_0 1 Tf 0 Tc 0 Tw -13.112 -1.218 Td [(\217)5.5(\036)-19(\007)-20.1(\026\022)-32.6(\021)-17.7(\017)1.4(\030)-11.8(\024)-4.2(\r)-9(\026\027)1.8(\017)-8.7(\036)6.5(:)]TJ /T1_2 1 Tf -0.01 Tc 0.01 Tw [( \206\032)0.7(\021\034\036)-7.9(\037)]TJ /Span<>> BDC 10.387 0 Td ( )Tj EMC [(\006)8.5(.)-2.7(\223)-12.2(.)]TJ /T1_1 1 Tf 0 Tc 0.023 Tw -10.387 -2.436 Td (AUTHORS CONTRIBUTION)Tj /T1_0 1 Tf 0.988 Tw T* [(C)-6.5(o)0.8(nce)-0.7(p)-12.3(t a)2.4(n)-4.6(d d)-5.5(e)-13.3(s)-16.6(i)3.2(g)1.2(n)15.4(:)]TJ /T1_2 1 Tf 0.001 Tc 0.987 Tw [( T)-1.6(i)9.4(mo)9.4(f)-8.3(e)-1.5(y)]TJ /Span<>> BDC 14.449 0 Td ( )Tj EMC [(L)-7.8(.)]TJ /Span<>> BDC 1.953 0 Td ( )Tj EMC [(A)4.6(l)5.8(e)-27.6(x)6(and)6.2(r)3.4(ov)34.6(,)1.1( )]TJ 0 Tc 0 Tw -16.401 -1.218 Td [(B)0.8(e)-1.9(ll)3.3(a)]TJ /Span<>> BDC ( )Tj EMC [(A)-12.5(.)]TJ /Span<>> BDC ( )Tj EMC [(V)-9(y)5.7(k)12.9(o)-0.6(v)10.8(a)]TJ /T1_0 1 Tf -0.08 Tw T* [(C)-6.5(o)-5.8(l)-19(l)-14.3(e)-9.4(c)-32.5(t)-37.3(i)3.2(o)0.8(n a)2.4(n)-4.6(d p)-3.8(r)-6(o)-7(ce)-13.3(s)-12.8(s)-16.5(i)7.1(n)-1.9(g o)-2.2(f d)0.7(a)-8.4(t)-27.7(a)4.2(:)]TJ /T1_2 1 Tf 0.001 Tc -0.081 Tw [( T)-1.7(i)9.5(mo)9.4(f)-8.3(e)-1.5(y)]TJ /Span<>> BDC 16.755 0 Td ( )Tj EMC [(L)-7.8(.)]TJ /Span<>> BDC 0.885 0 Td ( )Tj EMC [(A)4.6(l)5.8(e)-27.6(x)6(and)6.2(r)3.4(ov)]TJ /T1_0 1 Tf -0.052 Tc 0.052 Tw -17.64 -1.218 Td [(Te)-75.9(x)-88(t)-52( w)-73(r)-99.9(i)-58(t)-89.4(i)-44.9(n)-53.9(g)-43(:)]TJ /T1_2 1 Tf 0.001 Tc -0.001 Tw 5.233 0 Td [( T)-1.7(i)9.5(mo)9.4(f)-8.3(e)-1.5(y)]TJ /Span<>> BDC 3.307 0 Td ( )Tj EMC [(L)-7.8(.)]TJ /Span<>> BDC 0.965 0 Td ( )Tj EMC [(A)4.6(l)5.8(e)-27.6(x)6.1(and)6.2(r)3.4(ov)]TJ /T1_0 1 Tf 0.006 Tc -0.006 Tw -9.504 -1.218 Td [(E)11.6(dit)-31.4(i)13.1(n)4.1(g)15(:)]TJ /T1_2 1 Tf 0 Tc 0 Tw 3.238 0 Td [( B)0.8(e)-1.9(ll)3.3(a)]TJ /Span<>> BDC ( )Tj EMC [(A)-12.5(.)]TJ /Span<>> BDC ( )Tj EMC [(V)-9(y)5.7(k)12.9(o)-0.6(v)10.9(a)]TJ /T1_1 1 Tf 0.023 Tw -3.238 -2.436 Td (\255\026\036\031\036\025\034\224 \017\222 \032\026\020\017\022\032\231 $\ ORCID$)Tj /T1_0 1 Tf 0.167 Tw 0 -1.218 TD (\202\035\036\022\f\026\027\007\030\024\r \231\017\n\024\235\036\005 \214\ \036\024\027\017\007\024\r\017\004)Tj /Span<>> BDC ( )Tj EMC (\227 \n\035\026\007\001\017\005 \027\026)Tj 0 Tw (-)Tj 0.473 Tw 0 -1.218 TD (\031\004\027\t\005 \f\024\021\030\031\007\027\017\022 \024\021\007\036\035\ \026 \023\024)Tj /Span<>> BDC ( )Tj EMC (\017\031\004\036\027\017\033 \235\031\027\022\006\017\024)Tj 0 Tw (-)Tj 0.16 Tw 0 -1.218 TD (\027\026\035\034\027\t\b \017)Tj /Span<>> BDC ( )Tj EMC [(\r\024\f\023\026\035\017\021\036\035\034\027\t\b )0.5(\026\002\024\035\036\r\026\027\017\005 \022\017\001\036\004\027\017\022\ \026 )]TJ 0.221 Tw T* (\205\206\207\211 \253\203\204\224\037 \022\024\035\024\023\030\024\022\021\ \024\035\024\020\017\017 \017\n\036\027\017 \202.\203. \217\t\032\017\b\273\ )Tj 0 Tw T* (\204\017\027\007\030\026\r\026 \217\024\f\f\017\017; ORCID 0000-0002-88\ 03-7566)Tj 0.097 Tw T* (\200\t\022\024\r\026 \207\220\035\035\026 \202\035\036\022\f\026\027\007\ \030\024\r\027\026)Tj /Span<>> BDC ( )Tj EMC (\227 \022.\n.\027., \026\r\036\007\031\033\013\026\016 )Tj 0.403 Tw T* [(\020\026\f\021\030\024\220\027\021\036\030\024\035\024\020\017\004\036\f\ \022\017\n )0.6(\024\021\007\036\035\036\027\017\036\n )0.6(\205\206\207\211 )0.5(\253\203\204\224\037 )]TJ 0.482 Tw T* (\022\024\035\024\023\030\024\022\021\024\035\024\020\017\017 \017\n\036\027\ \017 \202.\203. \217\t\032\017\b\273 \204\017\027\007\030\026\r\026 )Tj 0 Tw T* (\217\024\f\f\017\017; ORCID 0000-0003-1697-4670)Tj /T1_1 1 Tf 0.023 Tw 0 -2.436 TD (INFORMATION ABOUT THE AUTHORS $ORCID$)Tj /T1_0 1 Tf 0 Tw 0 -1.218 TD [(T)35(imofei L. Ale)-17.9(x)-11(andr)-31.9(ov)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0002-8803-7566)Tj T* [(Bell)-16(a A. V)-15.9(ykov)-15(a)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0003-1697-4670)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 70.936 396.0239 Tm [(\r\031\024\034\033)48(\026)45(\024)-10(\223\033)48(\026/REFERENCES)]TJ 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.382 Tw 8 0 0 8 70.8661 383.1892 Tm (1.)Tj /Span<>> BDC ( )Tj EMC 1.327 0 Td (\207\031\007\017\027\f\022\026\016)Tj /Span<>> BDC ( )Tj EMC (\202.\202., \207\036\035\024\031\f\024\r\026)Tj /Span<>> BDC ( )Tj EMC (\213.\202., \200\026\022\031\030\024\r\026)Tj /Span<>> BDC ( )Tj EMC (\213.\225., \017)Tj /Span<>> BDC ( )Tj EMC [(\f\024\026\r\021.)10( )]TJ 0 Tc 0.076 Tw -1.327 -1.25 Td (\230\027\007\024\f\024\027\024\020\030\026\235\017\004\036\f\022\017\036\ \017\n\036\027\036\027\017\016 \023\024\007\032\036\035\031\007\024\004\ \027\024\005 \032\036\035\036\t \031)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\034)Tj 0 Tw (-)Tj 0.011 Tw 0 -1.25 TD (\027\t\b \f)Tj /Span<>> BDC ( )Tj EMC (\r\024\f\023\026\035\017\021\036\035\034\027\t\n\017 \026\002\024\035\036\ \r\026\027\017\016\n\017 \022\017\001\036\004\027\017\022\026 \017)Tj /Span<>> BDC ( )Tj EMC (\b\030\024\027\017\004\036\f\022\017\n )Tj 0 Tw T* (\023\026\027\022\030\036\026\021\017\021\024\n. )Tj /T1_2 1 Tf 0.349 Tw 6.595 0 Td (\212\021\024\f\016\033\022\003\016\020\035\037\027\215\020\037\030 \022)Tj /Span<>> BDC ( )Tj EMC (\021\027\022\020\022\201\016\024\021\037\030 \013\037\024\035\033\034\204\ \020\035\016)Tj 0 Tw (-)Tj 0.01 Tc -0.01 Tw -6.595 -1.25 Td (\033\034\027\034\013\022\030. )Tj /T1_0 1 Tf 0.366 Tw 4.267 0 Td [(2023;$3$:53\22660. d)-15.8(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs -0.01 Tw (10.31146/1682-8658-ecg-211-3-)Tj 0.004 Tc -0.004 Tw -4.267 -1.25 Td [(53-)0.5(60/)]TJ 0 0 0 1 k /GS1 gs 0.349 Tw [( Bud)17.4(z)0.5(insk)-16.5(a)15.4(y)22.4(a)]TJ /Span<>> BDC ( )Tj EMC [(A.A)0.5(., B)0.5(el)30.4(ou)0.5(sov)-14.6(a)]TJ /Span<>> BDC 15.571 0 Td ( )Tj EMC [(E.A.)0.5(, V)25.4(a)0.5(kur)-31.6(o)0.5(v)-14.6(a)]TJ /Span<>> BDC ( )Tj EMC [(E.S)0.5(., e)-11.5(t)]TJ /Span<>> BDC ( )Tj EMC [(a)0.5(l.)4( )]TJ 0 Tc -0.032 Tw -15.571 -1.25 Td [(End)-16(osono)-16(gr)-32.9(aphic changes of t)-13(he p)32(ancr)-24(eas in p)32(a)15(t)-32(ients wi)-24(t)-13(h infl)-16(amma)]TJ 0 Tw (-)Tj -0.083 Tw T* [(t)17(or)-24(y bo)-14(wel diseases and chr)-32(onic p)32(ancr)-24(ea)15(t)-32(i)-23.9(t)-32(is. )]TJ /T1_2 1 Tf [(Exper)-36.9(imental and clinical )]TJ 0 Tw T* [(g)12(astroenterology.)]TJ /T1_0 1 Tf 0.15 Tw [( 2023;$3$:53\22660. $in Russ.$. )0.5(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.31146/1682-)Tj T* (8658-ecg-211-3-53-60)Tj 0 0 0 1 k /GS1 gs 0.14 Tw T* (2.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Dar)-37(ie)]TJ /Span<>> BDC ( )Tj EMC [(AM, S)-16(inopoul)30(ou)]TJ /Span<>> BDC ( )Tj EMC [(V, Aja)15(y)]TJ /Span<>> BDC ( )Tj EMC [(V, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. BSG 2024 IBD guidel)-30.9(ines )]TJ -1.296 -1.25 Td [(p)25(r)-32(o)17(t)17(o)-16(col $st)15(and)42(ar)-24(d oper)-33(a)15(t)-32(ing p)25(r)-32(o)-15.9(cedur)-24(es$. )]TJ /T1_2 1 Tf (BMJ Open Gastroenterol)Tj /T1_0 1 Tf 0 Tw (. )Tj 0.023 Tw T* [(2023 F)10(eb;10$1$:e001067. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1136/bmjgast-2022-001067)Tj 0 0 0 1 k /GS1 gs 0.028 Tw T* (3.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Ell)-31(io)17.1(t)-30(t)]TJ /Span<>> BDC ( )Tj EMC (MJ, Maini)Tj /Span<>> BDC ( )Tj EMC [(RN, F)10(eldmann)]TJ /Span<>> BDC ( )Tj EMC [(M, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. R)-10(and)-16(omised d)-16(ouble-bl)-30.9(ind )]TJ 0.251 Tw -1.296 -1.25 Td [(com)10(p)32(ar)-37(ison of chimer)-37(ic mono)-15.9(cl)30(onal ant)-32(ibod)17(y t)17.1(o tumour necr)-32(osis )]TJ 0.16 Tw T* [(f)16(a)-17(c)-16(t)17(or )0.5(alpha )0.5($cA2$ )0.5(ver)-10(sus )0.5(pl)-16(a)-16.9(cebo in )0.5(r)-23.9(heuma)15(t)17(oid )0.5(ar)-22(t)-13(hr)-37(i)-23.9(t)-32(is. )]TJ /T1_2 1 Tf 0 Tw 24.763 0 Td (Lancet)Tj /T1_0 1 Tf (. )Tj 0.023 Tw -24.763 -1.25 Td [(1994;344$8930$:1105\22610. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1016/s0140-6736$94$90628-9)Tj 0 0 0 1 k /GS1 gs -0.028 Tw T* (4.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(T)40(ar)-32(gan)]TJ /Span<>> BDC ( )Tj EMC (SR, Hanauer)Tj /Span<>> BDC ( )Tj EMC [(SB, v)-15(an Deventer)]TJ /Span<>> BDC ( )Tj EMC [(SJH, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. A shor)-22(t-ter)-15.9(m stud)17(y )]TJ 0.039 Tw -1.296 -1.25 Td [(of chimer)-37(ic mono)-16(cl)30.1(onal ant)-32(ibod)17(y cA2 t)17(o tumor necr)-31.9(osis f)16(a)-17(c)-16(t)17(or alpha )]TJ 0.023 Tw T* [(for Cr)-32(ohn\254s disease. )]TJ /T1_2 1 Tf [(N Eng)12.9(l J Med.)]TJ /T1_0 1 Tf ( 1997;337$15$:1029\22635)Tj 0.09 Tw T* (5.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (Hanauer)Tj /Span<>> BDC ( )Tj EMC [(SB, F)10(ea)-17(gan)]TJ /Span<>> BDC ( )Tj EMC [(BG, L)-32(ichtenstein)]TJ /Span<>> BDC ( )Tj EMC [(GR, e)-11.9(t)]TJ /Span<>> BDC ( )Tj EMC (al. Maintenance inf)Tj 0 Tw (-)Tj 0.106 Tw -1.296 -1.25 Td [(l)-31(iximab for Cr)-32(ohn\254s disease: t)-13(he A)16(CCENT I r)-33(and)-16(omised tr)-37(ial. )]TJ /T1_2 1 Tf 0 Tw (Lancet)Tj /T1_0 1 Tf (. )Tj 0.023 Tw T* [(2002;359$9317$:1541\2269. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1016/S0140-6736$02$08512-4)Tj 0 0 0 1 k /GS1 gs 0.042 Tw T* (6.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Rutgeer)-21.9(ts)]TJ /Span<>> BDC ( )Tj EMC [(P, Sandbor)-15(n)]TJ /Span<>> BDC ( )Tj EMC [(W)31(J, F)10(ea)-17(gan)]TJ /Span<>> BDC ( )Tj EMC [(BG, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Infl)-30.9(iximab for induc)]TJ 0 Tw (-)Tj 0.119 Tw -1.296 -1.25 Td [(t)-32(ion and maintenance t)-13(her)-32.9(apy for ul)16(cer)-33(a)15(t)-32(i)-15.9(ve col)-31(i)-24(t)-32(is. )]TJ /T1_2 1 Tf [(N Eng)13(l J Med.)]TJ /T1_0 1 Tf 0 Tw ( )Tj 0.023 Tw T* [(2005;353$23$:2462\22676. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw [(10.1056/NEJM)-23.9(oa050516)]TJ 0 0 0 1 k /GS1 gs 0.157 Tw T* (7.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (Kim)Tj /Span<>> BDC ( )Tj EMC [(NH, L)35(ee)]TJ /Span<>> BDC ( )Tj EMC (JH, Hong)Tj /Span<>> BDC ( )Tj EMC [(SN, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. L)35(ong-ter)-16(m ef)-56(f)-28(ica)-16.9(cy and safe)-12(t)-9.9(y )]TJ 0.102 Tw -1.296 -1.25 Td [(of CT-P13, a biosimil)-16(ar of infl)-31(iximab, in p)32(a)15(t)-32(ients wi)-24(t)-13(h infl)-16(amma)15(t)17(or)-23.9(y )]TJ 0.225 Tw T* [(bo)-14(wel disease: A r)-24(e)-12(tr)-32(ospec)-15.9(t)-32(i)-16(ve mul)56(t)-32(icenter stud)17.1(y. )]TJ /T1_2 1 Tf (J Gastroenterol )Tj 0 Tw T* (Hepatol)Tj /T1_0 1 Tf 0.023 Tw [(. 2019;34$9$:1523\2261532. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1111/jgh.14645)Tj 0 0 0 1 k /GS1 gs 0.107 Tw T* (8.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Nenc)-24(ini)]TJ /Span<>> BDC ( )Tj EMC 3.452 0 Td [(F, )0.5(V)18(ul)56(t)15.1(a)-17(ggio)]TJ /Span<>> BDC ( )Tj EMC 5.089 0 Td [(A, )0.5(P)35(r)-32.9(a)15(tesi)]TJ /Span<>> BDC ( )Tj EMC 4.177 0 Td [(S, )0.5(e)-12(t)]TJ /Span<>> BDC ( )Tj EMC 2.158 0 Td [(al. )0.5(T)47(he )0.6(Kine)-12(t)-32(ics )0.6(of )0.5(Ant)-32(idr)-21.9(ug )]TJ -0.011 Tw 12.883 37.5 Td [(Ant)-32(ibodies, Dr)-22(ug L)35(evels, and Cl)-31(inical Outcomes in Infl)-31(iximab-E)35.1(xposed )]TJ 0.269 Tw T* [(P)40(a)15(t)-32(ients )0.5(wi)-24(t)-12.9(h Immune-Media)15(ted )0.5(Disor)-24(der)-10(s. )]TJ /T1_2 1 Tf 18.524 0 Td [(J )0.5(Allergy )0.5(ClinImmunol )]TJ 0 Tw -18.524 -1.25 Td (Pract.)Tj /T1_0 1 Tf 0.023 Tw [( 2018;6$6$:2065\2262072.e2. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1016/j.jaip.2018.04.007)Tj 0 0 0 1 k /GS1 gs 0.007 Tc 0.35 Tw T* (9.)Tj /Span<>> BDC ( )Tj EMC 1.318 0 Td (\203\031\030\017\026\b\n\036\021\024\r\026)Tj /Span<>> BDC ( )Tj EMC (\231.\222., \200\026\035\036\036\r\026)Tj /Span<>> BDC ( )Tj EMC (\224.\216., \221\036\r\027\017\027\026)Tj /Span<>> BDC ( )Tj EMC (\242.\210., \017)Tj /Span<>> BDC ( )Tj EMC [(\f\024\026\r\021.)7( )]TJ 0 Tc 0.122 Tw -1.318 -1.25 Td (\230\235\235\036\022\021\017\r\027\024\f\021\034 \017\027\020\017\002\017\ \021\024\030\024\r \235\026\022\021\024\030\026 \027\036\022\030\024\026\ \024\023\031\b\024\035\017 \264 \r)Tj /Span<>> BDC ( )Tj EMC (\035\036\004\036)Tj 0 Tw (-)Tj 0.014 Tc 0.515 Tw T* [(\027\017\017 \030\026\035\017\004\027\t\b \017\n\n\031\027\024\r\024\f\023\ \026\035\017\021\036\035\034\027\t\b \026\002\024\035\036\r\026\027\017\ \005: \235\024\022\031\f)14( )]TJ 0 Tc 0.193 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC 1.4 0 Td (\017\n\n\031\027\024\020\036\027\027\024\f\021\034. )Tj /T1_2 1 Tf 7.453 0 Td [(\217\034\036\033\016\003\016\020\020\037\030 )0.6(\033\016\036\003\037\035\034\027\034\013\022\030. )]TJ /T1_0 1 Tf 0 Tw 12.382 0 Td (2023;17$4$:35\226)Tj 0.064 Tw -21.235 -1.25 Td [(41. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.14412/1996-7012-2023-4-35-41)Tj 0 0 0 1 k /GS1 gs 0.064 Tw [( / Nur)-37(iakhme)-12(t)17(ov)-14.9(a)]TJ /Span<>> BDC ( )Tj EMC [(T.Y)35(u., )]TJ 0.006 Tw T* [(V)25(aleev)-15(a)]TJ /Span<>> BDC ( )Tj EMC [(I.H., S)-16(hevnina Y)50(a.O., e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. T)47(he ef)-56(fec)-16(t)-32(i)-16(veness of tumor necr)-31.9(o)]TJ 0 Tw (-)Tj 0.117 Tw T* [(sis )0.6(f)16(a)-17(c)-16(t)17(or )0.5(\264 )0.6(inhibi)-24(t)17(or)-10(s )0.6(in )0.5(t)-13(he )0.6(tr)-24(ea)15(tment )0.5(of )0.5(v)-14.9(ar)-37(ious )0.5(immuno-infl)-15.9(am)]TJ 0 Tw (-)Tj 0.187 Tw T* [(ma)15(t)17(or)-24(y diseases: fo)-16(cus on immuno)-15.9(genic)-24(i)-24(t)-10(y. )]TJ /T1_2 1 Tf [(Moder)-13.9(n rheumatology.)]TJ /T1_0 1 Tf 0 Tw ( )Tj 0.329 Tw T* [(2023;17$4$:35\22641. $in Russ.$. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.14412/1996-7012-2023-4-)Tj T* (35-41)Tj 0 0 0 1 k /GS1 gs 0.227 Tw T* (10.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(R)13(einisch)]TJ /Span<>> BDC ( )Tj EMC (W, Gecse)Tj /Span<>> BDC ( )Tj EMC [(K, Half)-25.9(v)-15(ar)-10(son)]TJ /Span<>> BDC ( )Tj EMC [(J, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. 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\023\030\024\007\024\035\032\026\035\017 \024\023\030\036\007\036\ \035\016\021\034\f\016 )Tj 0.206 Tw T* (\n\027\024\020\017\036 \020\024\007\t [66]. \212\035\016 \f\027\017\032\036\ \027\017\016 \r\036\030\024\016\021\027\024\f\021\017 \030\026)Tj 0 Tw (-)Tj 0.217 Tw T* (\r\017\021\017\016 \030\036\026\022\006\017\005 \020\017\023\036\030\004\ \031\r\f\021\r\017\021\036\035\034\027\024\f\021\017 \r)Tj /Span<>> BDC ( )Tj EMC (\027\026\f\021\024\016\013\036\036 )Tj 0.378 Tw T* (\r\030\036\n\016 \026\022\021\017\r\027\024 \017\f\023\024\035\034\031\036\ \021\f\016 \023\030\036\n\036\007\017\022\026\006\017\016 \023\036\030\036\ \007 )Tj 0.073 Tw T* (\r\r\036\007\036\027\017\036\n \f\206\025\225. \203\026)Tj /Span<>> BDC ( )Tj EMC (\027\026\001 \r\020\035\016\007, \220\021\017 \007\036\005\f\021\r\017\016\ \027\036 \027\036)Tj 0 Tw (-)Tj 0.05 Tw 0 -1.218 TD (\f\031\021 \024\f\024\002\024\020\024 \f\n\t\f\035\026. \217\036\026\022\ \006\017\017 \020\017\023\036\030\004\031\r\f\021\r\017\021\036\035\034\027\ \024\f\021\017 )Tj 0.254 Tw 0 -1.218 TD (\027\026)Tj /Span<>> BDC ( )Tj EMC (\235\024\027\036 \035\036\004\036\027\017\016 \224\203\205 \024\002\031\f\ \035\024\r\035\036\027\t \024\002\030\026\024\r\026\027\017\036\n )Tj 0.242 Tw T* [(\f\023\036\006\017\235\017\004\036\f\022\017\b )0.6(\023\030\024\021\017\r\024\035\036\022\026\030\f\021\r\036\027\027\t\b )0.6(\026\027\021\017\021\036\035, )0.6(\022\024)]TJ 0 Tw (-)Tj 0.008 Tw T* (\021\024\030\t\036 \023\024\n\017\n\024 \023\030\024\004\036\020\024 \002\ \035\024\022\017\030\031\033\021 \007\036\005\f\021\r\017\036 \023\030\036\ \023\026\030\026)Tj 0 Tw (-)Tj 0.154 Tw T* (\021\026 \017)Tj /Span<>> BDC ( )Tj EMC (\007\036\035\026\033\021 \023\030\024\007\024\035\032\036\027\017\036 \021\ \036\030\026\023\017\017 \002\036\f\f\n\t\f\035\036\027\027\t\n. )Tj 0.199 Tw T* [(\025\030\024\n\036 )0.5(\021\024\020\024, \023\024)]TJ /Span<>> BDC ( )Tj EMC [(\007\026\027\027\t\n )0.5(\n\036\021\026\026\027\026\035\017\026 )0.5(10 \017\f\f\035\036\007\024\r\026)]TJ 0 Tw (-)Tj 0.243 Tw 0 -1.218 TD (\027\017\005, \023\024\f\r\016\013\036\027\027\t\b \023\030\036\n\036\007\ \017\022\026\006\017\017 \023\036\030\036\007 \r\r\036\007\036\027\017\036\ \n )Tj 0.076 Tw 0 -1.218 TD [(\017\027\235\035\017\022\f\017\n\026\002\026, )0.6(\023\024\035\031\004\036\027\t )0.5(\007\026\027\027\t\036 )0.6(\024\002 )0.5(\024\021\f\031\021\f\021\r\017\017 )0.5(\027\026)]TJ 0 Tw (-)Tj 0.112 Tw 0 -1.218 TD (\004\017\n\024\005 \030\024\035\017 \023\030\036\n\036\007\017\022\026\006\ \017\017 \r)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\235\017\035\026\022\021\017\022\036 \030\036\026\022\006\017\ \005 )Tj 0 Tw T* (\020\017\023\036\030\004\031\r\f\021\r\017\021\036\035\034\027\024\f\021\ \017 [67].)Tj 0.312 Tw T* (\213\013\201 \024\007\027\017\n \027\036\n\026\035\024\r\026\032\027\t\n\ \026\f\023\036\022\021\024\n \002\036\024\023\026\f\027\024\f\021\017 \ )Tj 0.237 Tw T* (\023\030\017\n\036\027\036\027\017\016 \224\203\205 \016\r\035\016\036\021\ \f\016 \030\017\f\022 \f\036\030\034\036\027\t\b \017\027\235\036\022)Tj 0 Tw (-)Tj 0.231 Tw T* [(\006\017\005, )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC [(\021\024\n \004\017\f\035\036 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 8.857 0 Td [(\021\031\002\036\030\022\031\035\036\026. )0.5(\211\032\036 )0.5(\023\024\027\016\021\027\024, )0.5(\004\021\024 )]TJ 0.016 Tw -8.857 -1.218 Td (\030\017\f\022 \017\027\235\036\022\006\017\005 \023\030\017\002\035\017\ \017\021\036\035\034\027\024 \f\024\023\024\f\021\026\r\017\n \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 )Tj 0.045 Tw T* (\017\027\020\017\002\017\021\024\030\024\r \205\203\210-\026\035\034\235\ \026, \017)Tj /Span<>> BDC ( )Tj EMC (\r\t\001\036 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\022\024\n\002\017\027\026\006\017\017 \017\b )Tj 0.038 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\021\017\024\023\031\030\017\027\026\n\017 \017\035\017 \f\206\025\225 [\ 68\22671]. \200)Tj /Span<>> BDC ( )Tj EMC (\024\021\027\024\001\036\027\017\017 \f\030\026\r)Tj 0 Tw (-)Tj 0.138 Tw T* (\027\017\021\036\035\034\027\t\b \030\017\f\022\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\021\036\030\026\023\017\036\005 \007\030\031\020\017\n\017 \023\030\036\ \023\026\030\026\021\026\n\017 )Tj 0.128 Tw T* (\024\f\021\026\033\021\f\016 \r\024\023\030\024\f\t. \200)Tj /Span<>> BDC ( )Tj EMC (\017\f\f\035\036\007\024\r\026\027\017\016\b, \f\030\026\r\027\017\r\026\ \033\013\017\b )Tj 0.33 Tw T* (\004\026\f\021\024\021\031 \017\027\235\036\022\006\017\005 \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \027\026)Tj /Span<>> BDC ( )Tj EMC (\021\036\030\026\023\017\017 \206\224\207\215, )Tj 0.312 Tw T* (\026)Tj /Span<>> BDC ( )Tj EMC 1.434 0 Td [(\030\036\235\036\030\036\027\021\027\t\005 )0.6(\023\024)]TJ /Span<>> BDC ( )Tj EMC 7.697 0 Td [(\002\036\024\023\026\f\027\024\f\021\017 )0.6(\023\030\036\023\026\030\026\021 )0.5(\002\030\026\035\017 )]TJ 0.34 Tw -9.131 -1.218 Td (\r\036\007\024\035\017\031\n\026\002. \217\026\027\t\n\017 \017\f\f\035\ \036\007\024\r\026\021\036\035\016\n\017 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\n )Tj 0.367 Tw T* (\023\024\035\031\004\036\027\t \f\024\r\036\030\001\036\027\027\024 \030\ \026\027\024\024\002\030\026\027\t\036 \030\036\031\035\034\021\026\021\ \t. )Tj 0.089 Tw T* (\203\036\022\024\021\024\030\t\036 \017)Tj /Span<>> BDC ( )Tj EMC (\027\017\b \024\021\n\036\004\026\033\021 \027\026\004\017\n\024 \002\024\ \035\036\036 \r\t\f\024\022\017\036 )Tj 0.14 Tw T* (\030\017\f\022\017 \f\036\030\034\036\027\t\b \017\027\235\036\022\006\017\ \024\027\027\t\b \024\f\035\024\032\027\036\027\017\005 \027\026)Tj /Span<>> BDC ( )Tj EMC (\021\036)Tj 0 Tw (-)Tj -0.023 Tw T* [(\030\026\023\017\017 )0.5(\224\203\205 )0.6([72]. )0.5(\212\030\031\020\017\036 )0.5(\021\026\022\017\b )0.5(\030\026\035\017\004\017\005 )0.6(\027\036 )0.5(\024\021\n\036\004\026\033\021. )]TJ 0.013 Tw T* (\200)Tj /Span<>> BDC ( )Tj EMC (\030\036\021\030\024\f\023\036\022\021\017\r\027\024\n \026\027\026\035\017\ \036 4881)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\026 \f)Tj /Span<>> BDC ( )Tj EMC (\200\003\025, \023\024)Tj 0 Tw (-)Tj 0.028 Tw T* (\035\031\004\026\r\001\017\b \021\036\030\026\023\017\033 \017\027\020\017\ \002\017\021\024\030\026\n\017 \205\203\210 \017\035\017 \r\036\007\024\035\ \017\031)Tj 0 Tw (-)Tj 0.058 Tw T* (\n\026\002\024\n \r)Tj /Span<>> BDC ( )Tj EMC (\021\036\004\036\027\017\036 \020\024\007\026, \r\t\016\r\035\036\027\024\ , \004\021\024 \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \207\025 )Tj 0.027 Tw T* (\027\026\004\017\n\024\005 \030\026\027\017\006\t \r)Tj /Span<>> BDC ( )Tj EMC (\004\026\f\021\024\021\036 \f\036\030\034\036\027\t\b \017\027\235\036\022\ \006\017\005 \027\036 )Tj 0.093 Tw T* (\002\t\035\024 [69], \021\026\022\032\036 \022\026\022 \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\017 \030\036\021\030\024\f\023\036\022\021\017\r\027\024\n \026\ \027\026\035\017)Tj 0 Tw (-)Tj 0.017 Tw T* (\036 1266 \023\026\006\017\036\027\021\024\r, \023\024\035\031\004\026\r\ \001\017\b \017\027\020\017\002\017\021\024\030\t \205\203\210 \017\035\017\ )Tj 0.023 Tw T* (\r\036\007\024\035\017\031\n\026\002 \027\026)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\021\016\032\036\027\017\017 3 \035\036\021 [73]. \200)Tj /Span<>> BDC ( )Tj EMC (\024\021\027\024\001\036\027\017\017 )Tj 0.034 Tw T* (\030\017\f\022\024\r \021\031\002\036\030\022\031\035\036\026, \036\007\ \017\027\f\021\r\036\027\027\t\n \235\026\022\021\024\030\024\n, \027\026\ \004\017)Tj 0 Tw (-)Tj 0.02 Tw T* (\n\024 \r\035\017\016\033\013\017\n \027\026)Tj /Span<>> BDC ( )Tj EMC (\r\024\027\017\022\027\024\r\036\027\017\016 \021\031\002\036\030\022\031\ \035\036\026 )Tj /T1_2 1 Tf [(de nov)13(o)]TJ /T1_1 1 Tf 0 Tw ( )Tj 0.227 Tw T* (\031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \027\026)Tj /Span<>> BDC ( )Tj EMC (\021\036\030\026\023\017\017 \017\027\020\017\002\017\021\024\030\026\n\017\ \205\203\210-\026\035\034\235\026, )Tj 0.158 Tw T* (\016\r\017\035\026\f\034 \030\026\f\023\030\024\f\021\030\026\027\036\027\ \027\024\f\021\034 \026\022\021\017\r\027\024\020\024 \021\031\002\036\030\ \022\031\035\036\026 )Tj 0 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\030\036\020\017\024\027\036 \023\030\024\032\017\r\026\027\017\016 \023\ \026\006\017\036\027\021\026 [74].)Tj 0.198 Tw T* (\212\030\031\020\017\n \r\024\023\030\024\f\024\n \002\036\024\023\026\f\ \027\024\f\021\017 \016\r\035\016\036\021\f\016 \030\017\f\022 \r\024)Tj 0 Tw (-)Tj 0.188 Tw T* (\027\017\022\027\024\r\036\027\017\016 \027\024\r\024\024\002\030\026\024\ \r\026\027\017\005. \215\024)Tj /Span<>> BDC ( )Tj EMC (\007\026\027\027\t\n \002\024\035\034\001\017\b )Tj 0.255 Tw T* [(\027\026\006\017\024\027\026\035\034\027\t\b )0.5(\030\036\020\017\f\021\030\024\r \030\017\f\022 \030\036\006\017\007\017\ \r\026 \024\027\022\024\035\024\020\017)]TJ 0 Tw (-)Tj 0.164 Tw T* (\004\036\f\022\024\020\024 \026\002\024\035\036\r\026\027\017\016 \017\035\ \017 \r\024\027\017\022\027\024\r\036\027\017\016 \024\027\022\024\035\024\ \020\017)Tj 0 Tw (-)Tj 0.118 Tw T* (\004\036\f\022\024\020\024 \026\002\024\035\036\r\026\027\017\016 )Tj /T1_2 1 Tf [(de nov)13(o)]TJ /T1_1 1 Tf ( \027\036 \r\t\001\036, \004\036\n \r)Tj /Span<>> BDC ( )Tj EMC (\024\002\013\036\005 )Tj 0.087 Tw T* (\023\024\023\031\035\016\006\017\017 [75\22678]. \210\007\027\026\022\024\ , \r\036\030\024\016\021\027\024, \r\f\201 \r\t\001\036\f\022\026)Tj 0 Tw (-)Tj 0.237 Tw T* (\026\027\027\024\036 \027\036 \022\026\f\026\036\021\f\016 \030\017\f\022\ \026 \r\024\027\017\022\027\024\r\036\027\017\016 \035\017\n\235\024\n.\ )Tj 0.115 Tw T* (\025\024\n\002\017\027\017\030\024\r\026\027\027\026\016 \f)Tj /Span<>> BDC ( )Tj EMC (\021\017\024\023\031\030\017\027\026\n\017 \021\036\030\026\023\017\016 \ \224\203\205 \027\026)Tj 0 Tw (-)Tj 0.083 Tw T* (\004\017\n\024 \023\024\r\t\001\026\035\026 \030\017\f\022\017 \r\024\027\ \017\022\027\024\r\036\027\017\016 \035\017\n\235\024\n \f\030\026\r)Tj 0 Tw (-)Tj 0.018 Tw T* (\027\017\021\036\035\034\027\024 \f)Tj /Span<>> BDC ( )Tj EMC (\021\036\030\026\023\017\036\005 \007\030\031\020\017\n\017 \023\030\036\ \023\026\030\026\021\026\n\017 \017)Tj /Span<>> BDC ( )Tj EMC (\n\024\027\024\021\036)Tj 0 Tw (-)Tj T* (\030\026\023\017\036\005 \224\203\205 \017\035\017 \021\017\024\023\031\030\ \017\027\026\n\017 [79\22681].)Tj -0.002 Tc 1.433 Tw 23.244 64.543 Td [(\217\026\f\023\030\024\f\021\030\026\027\036\027\027\t\n \027\036\032\036\ \035\026\021\036\035\034\027\t\n\017 \016\r\035\036\027\017\036\n)-2( )]TJ 0.046 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC (\235\024\027\036 \021\036\030\026\023\017\017 \017\027\020\017\002\017\021\ \024\030\026\n\017 \205\203\210 \016\r\035\016\036\021\f\016 \030\026\r\ \017)Tj 0 Tc 0 Tw (-)Tj -0.002 Tc -0.018 Tw T* (\021\017\036 \023\026\030\026\007\024\022\f\026\035\034\027\024\020\024 \ \023\f\024\030\017\026\026. \215\030\017)Tj /Span<>> BDC ( )Tj EMC [(\030\036\021\030\024\f\023\036\022\021\017\r\027\024\n)-2( )]TJ 0.061 Tw T* (\026\027\026\035\017\036 676 \023\026\006\017\036\027\021\024\r, \023\024\ \035\031\004\026\r\001\017\b \224\203\205 \017\035\017 \026\007\026\035\017\ )Tj 0 Tc 0 Tw (-)Tj -0.002 Tc 0.168 Tw T* [(\n\031\n\026\002, )0.5(\r\t\016\r\035\036\027\024, )0.5(\004\021\024 )0.5(\023\026\030\026\007\024\022\f\026\035\034\027\t\005 )0.5(\023\f\024\030\017\026 )0.5(\030\026)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc -0.021 Tw T* (\r\017\035\f\016 \031)Tj /Span<>> BDC ( )Tj EMC (10,7% \023\024\f\035\036 \024\022\024\035\024 2-\b \035\036\021 \021\036\ \030\026\023\017\017 \220\021\017\n\017 \023\030\036)Tj 0 Tc 0 Tw (-)Tj -0.002 Tc 0.007 Tw 0 -1.218 TD [(\023\026\030\026\021\026\n\017. \205\026\022\021\024\030\026\n\017 \030\017\ \f\022\026 \030\026\r\017\021\017\016 \023\f\024\030\017\026\026 \002\t\ \035\017:)-2( )]TJ 0.092 Tw 0 -1.218 TD [(\032\036\027\f\022\017\005 \023\024\035, \f\021\030\017\022\021\031\030\017\ \030\031\033\013\017\005 \017\035\017 \023\036\027\036\021\030\017\030\031\ \033\013\017\005)-2( )]TJ 0 Tw T* (\235\036\027\024\021\017\023 \207\025, \017)Tj /Span<>> BDC ( )Tj EMC (\023\024\030\026\032\036\027\017\036 \r\036\030\b\027\017\b \024\021\007\ \036\035\024\r \240\025\231 [82].)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 275.0305 590.8718 Tm [(\020)21(\026\027\r\242\224\034\022\031\034)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0 Tc 0.123 Tw 10 0 0 10 274.9606 566.5158 Tm (\203\036\f\n\024\021\030\016 \027\026)Tj /Span<>> BDC ( )Tj EMC (\023\024\016\r\035\036\027\017\036 \027\024\r\t\b \206\224\207\215 \017)Tj /Span<>> BDC ( )Tj EMC (\231\224\225, \021\036\030\026\023\017\016 )Tj 0.014 Tw T* (\023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\200\003\025 \017\027\020\017\002\017\021\024\030\026\n\017 \205\203\210\ -\026\035\034\235\026, \r)Tj /Span<>> BDC ( )Tj EMC (\004\026\f\021\027\024)Tj 0 Tw (-)Tj 0.044 Tw T* (\f\021\017 \224\203\205, \023\030\024\007\024\035\032\026\036\021 \024\f\ \021\026\r\026\021\034\f\016 \026\022\021\031\026\035\034\027\024\005. \203\ \026)Tj /Span<>> BDC ( )Tj EMC (\027\026\001 )Tj 0.14 Tw T* (\r\020\035\016\007, \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\r\f\036\b \024\021\030\017\006\026\021\036\035\034\027\t\b \n\024\n\036\ \027\021\026\b \021\026\022\024\005 \021\036)Tj 0 Tw (-)Tj 0.341 Tw T* (\030\026\023\017\017, \023\024\035\027\024\f\021\034\033 \r\024\n\024\032\ \027\024\f\021\017 \023\030\017\n\036\027\036\027\017\016 \220\021\024\020\ \024 )Tj 0.119 Tw T* (\023\030\036\023\026\030\026\021\026 \007\026\035\036\022\024 \027\036 \017\ \f\004\036\030\023\026\027\t. \210\f\021\026\036\021\f\016 \007\024\r\024\ \035\034\027\024 )Tj 0.051 Tw T* (\n\027\024\020\024 \r\024\023\030\024\f\024\r, \021\030\036\002\031\033\013\ \017\b \007\026\035\034\027\036\005\001\036\020\024 \031\021\024\004\027\ \036\027\017\016, )Tj 0.01 Tw T* (\024\007\027\026\022\024 \016\f\027\024, \004\021\024 \224\203\205 \036\013\ \201 \007\024\035\020\024 \002\031\007\036\021 \r\b\024\007\017\021\034 \ \r)Tj /Span<>> BDC ( )Tj EMC (\f\b\036)Tj 0 Tw (-)Tj T* (\n\t \021\036\030\026\023\017\017 \200\003\025.)Tj 0.231 Tw T* (\231\030\036\002\031\033\021 \031\021\024\004\027\036\027\017\016 \235\026\ \022\021\024\030\t, \r\035\017\016\033\013\017\036 \027\026)Tj /Span<>> BDC ( )Tj EMC (\220\235\235\036\022)Tj 0 Tw (-)Tj 0.139 Tw T* (\021\017\r\027\024\f\021\034 \021\036\030\026\023\017\017. \211\032\036 \ \023\024\027\016\021\027\024, \004\021\024 \024\f\027\024\r\027\t\n \235\ \026\022)Tj 0 Tw (-)Tj 0.834 Tw T* (\021\024\030\024\n, \024\023\030\036\007\036\035\016\033\013\017\n \r\t\f\ \024\022\031\033 \220\235\235\036\022\021\017\r\027\024\f\021\034 )Tj 0.762 Tw T* (\021\036\030\026\023\017\017, \016\r\035\016\036\021\f\016 \235\026\030\n\ \026\022\024\022\017\027\036\021\017\022\026 \023\030\036\023\026\030\026\ \021\026. )Tj 0.186 Tw T* (\211)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\r\t\f\024\022\024\005 \023\035\026\n\036\027\027\024\005 \022\024\027\006\ \036\027\021\030\026\006\017\036\005 )Tj -0.007 Tw T* (\224\203\205 \035\031\004\001\036 \017\f\b\024\007\t \017)Tj /Span<>> BDC ( )Tj EMC (\r\t\032\017\r\026\036\n\024\f\021\034 \021\036\030\026\023\017\017. \224\ \n\036\027\027\024 )Tj 0.486 Tw T* (\220\021\017\n \024\002\255\016\f\027\016\036\021\f\016 \002\024\035\036\ \036 \r\t\f\024\022\026\016 \220\235\235\036\022\021\017\r\027\024\f\021\ \034 )Tj 0.172 Tw T* [(\035\036\004\036\027\017\016 )0.5(\031)]TJ /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\r\t\f\024\022\017\n \224\204\231, \021\024 \036\f\021\034 \r)Tj /Span<>> BDC ( )Tj EMC (\021\036\b )Tj 0.139 Tw T* (\f\035\031\004\026\016\b, \022\024\020\007\026 \007\024\026 \023\030\036\ \023\026\030\026\021\026 \r\t\001\036, \017)Tj /Span<>> BDC ( )Tj EMC (\031 \023\026\006\017\036\027\021\024\r )Tj 0.426 Tw T* (\023\024\035\031\004\026\033\013\017\b \022\024\n\002\017\027\017\030\024\ \r\026\027\027\031\033 \021\036\030\026\023\017\033 \f)Tj /Span<>> BDC ( )Tj EMC (\021\017\024\023\031)Tj 0 Tw (-)Tj 0.272 Tw T* (\030\017\027\026\n\017, \f\027\017\032\026\033\013\017\n\017 \017\n\n\031\ \027\024\020\036\027\027\024\f\021\034 \023\030\036\023\026\030\026\021\024\ \r. )Tj 0.504 Tw T* (\215\036\030\f\023\036\022\021\017\r\027\t\n \016\r\035\016\036\021\f\016\ \021\036\030\026\023\036\r\021\017\004\036\f\022\017\005 \035\036\022\026\ \030)Tj 0 Tw (-)Tj 0.135 Tw T* [(\f\021\r\036\027\027\t\005 )0.5(\n\024\027\017\021\024\030\017\027\020 )0.5($\231\214\204$ \022\026\022 \r)]TJ /Span<>> BDC ( )Tj EMC [(\024\021\027\024\001\036\027\017\017 )0.5(\023\030\024\020)]TJ 0 Tw (-)Tj -0.019 Tw T* [(\027\024\017\030\024\r\026\027\017\016 )0.5(\220\235\235\036\022\021\026 )0.5(\035\036\004\036\002\027\t\b )0.5(\n\036\030\024\023\030\017\016\021\017\005, \021\026\022 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 21.636 0 Td (\r )Tj 0.146 Tw -21.636 -1.218 Td (\030\026\n\022\026\b \023\036\030\f\024\027\026\035\017\017\030\024\r\026\ \027\027\024\005 \024\023\021\017\n\017\026\006\017\017 \021\036\030\026\ \023\017\017 )Tj 0.077 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\022\024\027\021\030\024\035\016 \030\036\n\017\f\f\017\017. \025\030\024\ \n\036 \021\024\020\024, \r\036\007\036\021\f\016 \026\022\021\017\r\027\ \t\005 )Tj -0.005 Tw T* (\023\024\017\f\022 \023\030\036\007\017\022\021\024\030\024\r \220\235\235\ \036\022\021\017\r\027\024\f\021\017 \021\036\030\026\023\017\017 \007\024\ )Tj /Span<>> BDC ( )Tj EMC (\036\201 \027\026)Tj 0 Tw (-)Tj 0.242 Tw T* (\004\026\035\026. \203\026\017\002\024\035\036\036 \024\002\024\f\027\024\ \r\026\027\027\t\n\017 \r)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\n \024\021\027\024\001\036\027\017\017 )Tj 0.163 Tw T* (\016\r\035\016\033\021\f\016, \023\024-\r\017\007\017\n\024\n\031, \021\022\ \026\027\036\r\026\016 \022\024\027\006\036\027\021\030\026\006\017\016 \ \024\027)Tj 0 Tw (-)Tj 0.139 Tw T* (\022\024\f\021\026\021\017\027\026 \204 \017)Tj /Span<>> BDC ( )Tj EMC (\023\035\026\n\036\027\027\026\016 \022\024\027\006\036\027\021\030\026\ \006\017\016 \030\036\006\036\023\021\024\030\026 )Tj 0.194 Tw T* (TREM-1, \220\022\f\023\030\036\f\f\017\030\031\036\n\024\020\024 \027\026\ )Tj /Span<>> BDC ( )Tj EMC (\023\024\r\036\030\b\027\024\f\021\017 \n\024\027\024\006\017)Tj 0 Tw (-)Tj T* (\021\024\r \017)Tj /Span<>> BDC ( )Tj EMC (\027\036\005\021\030\024\235\017\035\024\r.)Tj 0.108 Tw T* [(\200 )0.5(\027\026\f\021\024\016\013\036\036 )0.5(\r\030\036\n\016 )0.5(\f\031\013\036\f\021\r\031\033\021 )0.5(\030\026\027\024\024\002\030\026\027\t\036 )0.6(\f\023\024)]TJ 0 Tw (-)Tj 0.168 Tw T* (\f\024\002\t \024\023\021\017\n\017\026\006\017\017 \021\036\030\026\023\ \017\017 \224\203\205 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\023\024\021\036\030\036 \024\021\r\036\021\026 )Tj 0.116 Tw T* (\017\035\017 \027\036\007\024\f\021\026\021\024\004\027\024\005 \220\235\ \235\036\022\021\017\r\027\024\f\021\017 \021\036\030\026\023\017\017, \024\ \007\027\026\022\024, )Tj 0.045 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC (\027\026\001 \r\020\035\016\007, \002\031\007\031\013\036\036 \r)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\n \r\024\023\030\024\f\036 \026)Tj /Span<>> BDC ( )Tj EMC (\024\023\021\017\n\017\026)Tj 0 Tw (-)Tj T* (\006\017\036\005, \024\f\027\024\r\026\027\027\024\005 \027\026)Tj /Span<>> BDC ( )Tj EMC (\231\214\204.)Tj 0.175 Tw T* (\200 \024\021\027\024\001\036\027\017\017 \022\024\027\021\030\024\035\016\ \220\235\235\036\022\021\017\r\027\024\f\021\017 \021\036\030\026\023\017\ \017 \r\f\201 )Tj -0.038 Tw T* (\002\024\035\034\001\036\036 \n\036\f\021\024 \026\027\017\n\026\033\021\ \027\036\017\027\r\026\017\r\027\t\036 \n\036\021\024\007\017\022\017,\ \021\026)Tj 0 Tw (-)Tj -0.039 Tw T* (\022\017\036 \022\026\022 \024\023\030\036\007\036\035\036\027\017\036 \225\ \217\207, \205\025\215 \017)Tj /Span<>> BDC ( )Tj EMC (\021\030\026\027\f\026\002\007\024\n\017\027\026\035\034\027\024\036 )Tj -0.037 Tw T* [(\211\003\224 \022\017\001\036\004\027\017\022\026, \023\024\022\026\t\r\ \026\033\013\017\036 )0.5(\r\t\f\024\022\017\036 \004\031\r\f\021\r\017\021\036\035\034)]TJ 0 Tw (-)Tj T* (\027\024\f\021\034 \017)Tj /Span<>> BDC ( )Tj EMC (\f\023\036\006\017\235\017\004\027\024\f\021\034 \r)Tj /Span<>> BDC ( )Tj EMC (\220\021\017\b \r\024\023\030\024\f\026\b.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\205)10(\210\036\033 \035\030\032\204\033)30(\021)42(\032)-21(\211\033\237)]TJ 57.136 0 Td (REVIEW)Tj /T1_4 1 Tf 25 0 0 25 505.5644 56.0378 Tm (179)Tj ET endstream endobj 500 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.146 Tw 10 0 0 10 70.8661 724.8299 Tm (\200 \024\021\036\004\036\f\021\r\036\027\027\t\b \017\f\f\035\036\007\024\ \r\026\027\017\016\b \023\024\035\031\004\036\027\t \023\030\024\021\017\ \r\024)Tj 0 Tw (-)Tj 0.117 Tw 0 -1.218 TD (\030\036\004\017\r\t\036 \007\026\027\027\t\036 \220\235\235\036\022\021\ \017\r\027\024\f\021\017 \017)Tj /Span<>> BDC ( )Tj EMC (\002\036\024\023\026\f\027\024\f\021\017 \021\026)Tj 0 Tw (-)Tj -0.021 Tw T* [(\022\024\020\024 )0.5(\023\036\030\036\022\035\033\004\036\027\017\016. )0.6(\025\027\016\036\r )0.6(\210.\200. )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 14.292 0 Td [(\f\024\026\r\021. )0.5(\023\030\017)]TJ /Span<>> BDC ( )Tj EMC 4.494 0 Td (\026\027\026\035\017\036 )Tj -0.044 Tw -18.786 -1.218 Td (\017\f\b\024\007\024\r \021\036\030\026\023\017\017 \224\203\205 \023\026\ \006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\200\003\025, \022\024\021\024\030\t\b \023\036\030\036)Tj 0 Tw (-)Tj 0.064 Tw T* (\022\035\033\004\017\035\017 \f)Tj /Span<>> BDC ( )Tj EMC (\024\030\017\020\017\027\026\035\034\027\024\020\024 \023\030\036\023\026\ \030\026\021\026 \027\026)Tj /Span<>> BDC ( )Tj EMC (\002\017\024\f\017\n\017\035\016\030, )Tj 0.094 Tw T* (\024\021\n\036\021\017\035\017 \f\027\017\032\036\027\017\036 \r\t\032\017\ \r\026\036\n\024\f\021\017 \021\036\030\026\023\017\017 \r)Tj /Span<>> BDC ( )Tj EMC (3 \030\026\026 )Tj 0.237 Tw 0 -1.218 TD ([48]. \225)Tj /Span<>> BDC ( )Tj EMC (\007\030\031\020\024\005 \f\021\024\030\024\027\t, \r)Tj /Span<>> BDC ( )Tj EMC (\017\f\f\035\036\007\024\r\026\027\017\017 \215\036\007\026)Tj /Span<>> BDC ( )Tj EMC (\213.\225. )Tj 0.077 Tw 0 -1.218 TD (\017)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. \023\024\f\035\036 \023\036\030\036\022\035\033\004\036\ \027\017\016 \027\026)Tj /Span<>> BDC ( )Tj EMC (\002\017\024\f\017\n\017\035\016\030, \027\036 \023\024)Tj 0 Tw (-)Tj 0.112 Tw T* (\035\031\004\036\027\024 \031\002\036\007\017\021\036\035\034\027\t\b \007\ \026\027\027\t\b \027\017 \r)Tj /Span<>> BDC ( )Tj EMC (\024\021\027\024\001\036\027\017\017 \r\035\017\016)Tj 0 Tw (-)Tj 0.136 Tw T* (\027\017\016 \022\026\022 \027\026)Tj /Span<>> BDC ( )Tj EMC (\r\t\032\017\r\026\036\n\024\f\021\034 \021\036\030\026\023\017\017, \021\ \026\022 \017)Tj /Span<>> BDC ( )Tj EMC (\027\026 \235\026\022\021\024\030 )Tj 0 Tw T* (\002\036\024\023\026\f\027\024\f\021\017 [49].)Tj 0.014 Tc 0.08 Tw T* (\215\030\017 \220\021\024\n \023\024\f\035\036\007\027\017\036 \n\017\030\ \024\r\t\036 \007\026\027\027\t\036 \023\024)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\n\031 \023\024)Tj 0 Tc 0 Tw (-)Tj 0.014 Tc 0.308 Tw 0 -1.218 TD (\r\024\007\031 \007\024\r\024\035\034\027\024 \024\023\021\017\n\017\f\021\ \017\004\027\t, \022\024\027\036\004\027\024, \f)Tj /Span<>> BDC ( )Tj EMC [(\031\004\036\021\024\n)14( )]TJ 0.004 Tw 0 -1.218 TD (\024\020\030\026\027\017\004\036\027\017\005, \031\022\026\026\027\027\t\ \b \r)Tj /Span<>> BDC ( )Tj EMC (\027\026\004\026\035\036 \030\026\007\036\035\026. \200)Tj /Span<>> BDC ( )Tj EMC (\017\f\f\035\036)Tj 0 Tc 0 Tw (-)Tj 0.014 Tc -0.024 Tw 0 -1.218 TD (\007\024\r\026\027\017\017 \f)Tj /Span<>> BDC ( )Tj EMC [(\031\004\026\f\021\017\036\n 168 )0.5(\023\026\006\017\036\027\021\024\r \031\f\021\026\027\024\r\035\036\027\024\ , \004\021\024)14( )]TJ 0.126 Tw T* [(\023\036\030\036\022\035\033\004\036\027\017\036 )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC 7.345 0 Td [(\024\030\017\020\017\027\026\035\034\027\024\020\024 )0.5(\023\030\036\023\026\030\026\021\026 )0.5(\027\026)]TJ /Span<>> BDC ( )Tj EMC 12.847 0 Td (\002\017\024)Tj 0 Tc 0 Tw (-)Tj 0.014 Tc 0.044 Tw -20.192 -1.218 Td (\f\017\n\017\035\016\030 \017)Tj /Span<>> BDC ( )Tj EMC (\024\002\030\026\021\027\024, \023\036\030\036\022\035\033\004\036\027\017\ \036 \n\036\032\007\031 \002\017\024\f\017\n\017)Tj 0 Tc 0 Tw (-)Tj 0.014 Tc -0.011 Tw T* [(\035\016\030\026\n\017, )0.6(\r)]TJ /Span<>> BDC ( )Tj EMC 4.243 0 Td [(\021\024\n )0.6(\004\017\f\035\036 )0.5(2 )0.6(\030\026\026 )0.6(\026)]TJ /Span<>> BDC ( )Tj EMC 8.45 0 Td [(12 )0.6(\n\036\f\016\006\036\r, )0.5(\027\036 )0.5(\r\035\017\016\035\024)14( )]TJ 0.103 Tw -12.693 -1.218 Td (\027\017 \027\026)Tj /Span<>> BDC ( )Tj EMC (\220\235\235\036\022\021\017\r\027\024\f\021\034, \027\017 \027\026)Tj /Span<>> BDC ( )Tj EMC [(\002\036\024\023\026\f\027\024\f\021\034 \021\036\030\026\023\017\017)14( )]TJ T* ([48]. Jahnsen J. \027\026)Tj /Span<>> BDC ( )Tj EMC (37 \023\026\006\017\036\027\021\026\b \f)Tj /Span<>> BDC ( )Tj EMC (\207\025 \023\024\022\026\026\035 \024\021)Tj 0 Tc 0 Tw (-)Tj 0.014 Tc 0.124 Tw T* [(\f\031\021\f\021\r\017\036 )0.5(\023\030\024\002\035\036\n )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC 8.832 0 Td [(\220\235\235\036\022\021\017\r\027\024\f\021\034\033 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 8.488 0 Td (\002\036\024\023\026\f\027\024)Tj 0 Tc 0 Tw (-)Tj 0.014 Tc 0.204 Tw -17.32 -1.218 Td (\f\021\034\033 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\036\022\035\033\004\036\027\017\017 \f)Tj /Span<>> BDC ( )Tj EMC (\217\036\n\017\022\036\005\007\026 \027\026)Tj /Span<>> BDC ( )Tj EMC [(\217\036\n\017\f\n\031)14.1( )]TJ 0.244 Tw T* ([21]. \200)Tj /Span<>> BDC ( )Tj EMC [(\n\036\021\026\026\027\026\035\017\036, \r\022\035\033\004\026\033\013\036\ \n 14225 \f\035\031\004\026\036\r)14( )]TJ 0.544 Tw T* [(\023\036\030\036\022\035\033\004\036\027\017\016 )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC 8.186 0 Td [(\024\030\017\020\017\027\026\035\034\027\024\020\024 )0.5(\002\017\024\035\024\020\017\004\036\f\022\024\020\024)14( )]TJ 0.317 Tw -8.186 -1.218 Td [(\023\030\036\023\026\030\026\021\026 )0.5(\027\026)]TJ /Span<>> BDC ( )Tj EMC 6.497 0 Td [(\002\017\024\f\017\n\017\035\016\030, )0.6(\027\036 )0.5(\r\t\016\r\035\036\027\024 )0.5(\027\017\022\026\022\017\b)14( )]TJ 0.23 Tw -6.497 -1.218 Td (\030\026\035\017\004\017\005 \r)Tj /Span<>> BDC ( )Tj EMC (\220\235\235\036\022\021\017\r\027\024\f\021\017 \017)Tj /Span<>> BDC ( )Tj EMC (\002\036\024\023\026\f\027\024\f\021\017 \f\030\026\r)Tj 0 Tc 0 Tw (-)Tj 0.014 Tc 0.207 Tw T* (\027\017\021\036\035\034\027\024 \f)Tj /Span<>> BDC ( )Tj EMC [(\023\030\024\007\024\035\032\036\027\017\036\n \021\036\030\026\023\017\017\ \024\030\017\020\017\027\026\035\034\027\t\n)14( )]TJ 0.356 Tw T* (\023\030\036\023\026\030\026\021\024\n [49]. \200)Tj /Span<>> BDC ( )Tj EMC (\n\027\024\020\024\006\036\027\021\030\024\r\024\n \030\026\027\007\024\n\ \017\017)Tj 0 Tc 0 Tw (-)Tj 0.014 Tc 0.092 Tw T* (\030\024\r\026\027\027\024\n \017\f\f\035\036\007\024\r\026\027\017\017 \ \f)Tj /Span<>> BDC ( )Tj EMC [(\031\004\026\f\021\017\036\n 111 \023\026\006\017\036\027\021\024\r)14( )]TJ -0.015 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\036\027\034\033 \025\030\024\027\026 \r)Tj /Span<>> BDC ( )Tj EMC (\021\036\004\036\027\017\036 54)Tj /Span<>> BDC ( )Tj EMC [(\027\036\007\036\035\034 \023\030\024\r\024\007\017\035\024\f\034)14( )]TJ 0.002 Tw T* [(\023\036\030\036\022\035\033\004\036\027\017\036 )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC 7.097 0 Td [(\030\036\235\036\030\036\027\021\027\024\020\024 )0.5(\224\203\205 )0.5(\027\026)]TJ /Span<>> BDC ( )Tj EMC 9.671 0 Td [(\002\017\024\f\017\n\017\035\016\030,)14( )]TJ -0.044 Tw -16.768 -1.218 Td (\023\036\030\036\022\035\033\004\036\027\017\036 \f)Tj /Span<>> BDC ( )Tj EMC (\002\017\024\f\017\n\017\035\016\030\026 \027\026)Tj /Span<>> BDC ( )Tj EMC [(\030\036\235\036\030\036\027\021\027\t\005 \224\203\205,)14( )]TJ 0.402 Tw T* (\023\030\024\007\024\035\032\036\027\017\036 \021\036\030\026\023\017\017\ \002\017\024\f\017\n\017\035\016\030\024\n \017\035\017 \030\036\235\036\ )Tj 0 Tc 0 Tw (-)Tj 0.014 Tc 0.057 Tw T* (\030\036\027\021\027\t\n \224\203\205. \215\030\017)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\n \030\026\035\017\004\017\005 \r)Tj /Span<>> BDC ( )Tj EMC (\031\030\024\r\027\036 \f\027\017\032\036)Tj 0 Tc 0 Tw (-)Tj 0.014 Tc 0.071 Tw T* (\027\017\016 \017\027\007\036\022\f\026 \026\022\021\017\r\027\024\f\021\ \017 \207\025 \027\026)Tj /Span<>> BDC ( )Tj EMC [(\022\024\027\021\030\024\035\034\027\t\b \021\024\004\022\026\b)14( )]TJ -0.016 Tw T* (\030\026\027\017\006\t \027\036 \023\024\035\031\004\036\027\024 [50]. \ \231\026\022\032\036 \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC [(\200\003\025)14( )]TJ 0.739 Tw T* [(\027\036 \n\036\027\016\035\017\f\034 \235\026\030\n\026\022\024\022\017\ \027\036\021\017\004\036\f\022\017\036 \023\026\030\026\n\036\021\030\t)14( )]TJ 0.04 Tw T* (\023\030\017)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\036\022\035\033\004\036\027\017\017 \f)Tj /Span<>> BDC ( )Tj EMC (\024\030\017\020\017\027\026\035\034\027\024\020\024 \224\203\205 \027\026\ )Tj /Span<>> BDC ( )Tj EMC (\002\017\024\f\017)Tj 0 Tc 0 Tw (-)Tj 0.014 Tc T* (\n\017\035\016\030 [51].)Tj /T1_1 1 Tf 0 Tc 0 -2.436 TD (\017\217\002\206\013\r \220\f\t\b\t\201\r\217\220\t\r \217\t\003\210\004\ \204\t\t)Tj /T1_0 1 Tf 0.272 Tw 0 -1.218 TD [(\224\203\205 \007\024\035\034\001\036 )0.5(\007\030\031\020\017\b )0.5(\206\224\207\215 \017\f\023\024\035\034\031\036\021\f\016 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC (\031\f\035\024\r\017)Tj 0 Tw (-)Tj 0.147 Tw T* (\016\b \030\036\026\035\034\027\024\005 \022\035\017\027\017\004\036\f\022\ \024\005 \023\030\026\022\021\017\022\017. \200)Tj /Span<>> BDC ( )Tj EMC (\f\r\016\017 \f)Tj /Span<>> BDC ( )Tj EMC (\220\021\017\n )Tj 0.152 Tw T* [(\n\017\030\024\r\t\n \027\026\031\004\027\t\n \f\024\024\002\013\036\f\021\ \r\024\n )0.5(\027\026\022\024\023\035\036\027 \007\024\r\024\035\034\027\024 )]TJ 0.241 Tw T* (\002\024\035\034\001\024\005 \024\023\t\021 \023\030\017\n\036\027\036\027\ \017\016 \023\030\036\023\026\030\026\021\026 \r)Tj /Span<>> BDC ( )Tj EMC (\027\036\022\024\021\024\030\t\b )Tj 0.023 Tw T* (\022\035\017\027\017\004\036\f\022\017\b \f\017\021\031\026\006\017\016\b\ . \210\007\027\024\005 \017)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\017\b \022\035\017\027\017\004\036\f\022\017\b )Tj -0.049 Tw T* (\f\017\021\031\026\006\017\005 \016\r\035\016\036\021\f\016 \021\016\032\ \036\035\026\016 \026\021\026\022\026 \242\025 \f)Tj /Span<>> BDC ( )Tj EMC (\016\r\035\036\027\017\016\n\017 \020\024\030)Tj 0 Tw (-)Tj 0.058 Tw T* [(\n\024\027\026\035\034\027\024\005 \030\036\017\f\021\036\027\021\027\024\ \f\021\017. )0.5(\215\024)]TJ /Span<>> BDC ( )Tj EMC (\007\026\027\027\t\n \f\017\f\021\036\n\026\021\017\004\036)Tj 0 Tw (-)Tj 0.114 Tw T* (\f\022\024\020\024 \035\017\021\036\030\026\021\031\030\027\024\020\024 \ \024\002\024\030\026 2016 \020., \220\235\235\036\022\021\017\r\027\024\ \f\021\034 )Tj 0.007 Tw T* (\224\203\205 \r)Tj /Span<>> BDC ( )Tj EMC (\022\026\004\036\f\021\r\036 \253\021\036\030\026\023\017\017 \f\023\026\ \f\036\027\017\016\273 \f\024\f\021\026\r\017\035\026 43,8% )Tj 0.096 Tw T* ([52]. \200)Tj /Span<>> BDC ( )Tj EMC (\027\026\f\021\024\016\013\036\036 \r\030\036\n\016 \024\027 \f\004\017\021\ \026\036\021\f\016 \030\036\235\036\030\036\027\021\027\t\n )Tj -0.01 Tw T* [(\023\030\036\023\026\030\026\021\024\n )0.5(\007\035\016 )0.6(\024\006\036\027\022\017 )0.5(\220\235\235\036\022\021\017\r\027\024\f\021\017 )0.5(\007\030\031\020\017\b )0.6(\027\024\r\t\b )]TJ 0.141 Tw T* (\035\036\022\026\030\f\021\r\036\027\027\t\b \026\020\036\027\021\024\r \ \r)Tj /Span<>> BDC ( )Tj EMC (\035\036\004\036\027\017\017 \021\016\032\036\035\t\b \026\021\026\022 \242\ \025, )Tj 0 Tw T* (\030\036\017\f\021\036\027\021\027\t\b \022)Tj /Span<>> BDC ( )Tj EMC (\021\036\030\026\023\017\017 \f\206\025\225 [53].)Tj 0.005 Tw 23.244 64.543 Td (\200 \n\036\021\026\026\027\026\035\017\036 2021 \020. \024\006\036\027\ \017\r\026\035\017 \017\f\b\024\007\t \017\027\007\031\022\006\017\024\027\ )Tj 0 Tw (-)Tj 0.1 Tw T* (\027\024\005 \021\036\030\026\023\017\017 \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \f\024 \f\030\036\007\027\036\021\016\ \032\036\035\024\005 \017)Tj /Span<>> BDC ( )Tj EMC (\021\016\032\036)Tj 0 Tw (-)Tj 0.121 Tw T* [(\035\024\005 )0.5(\235\024\030\n\026\n\017 )0.6(\207\025. )0.5(\210\023\030\036\007\036\035\036\027\024, )0.6(\004\021\024 )0.5(\031)]TJ /Span<>> BDC ( )Tj EMC 15.736 0 Td [(\220\021\024\005 )0.5(\022\026\021\036\020\024\030\017\017 )]TJ 0.12 Tw -15.736 -1.218 Td (\023\026\006\017\036\027\021\024\r \224\203\205 \r)Tj /Span<>> BDC ( )Tj EMC (\022\024\n\002\017\027\026\006\017\017 \f)Tj /Span<>> BDC ( )Tj EMC (\026\026\021\017\024\023\030\017\027\024\n, \026\007\026)Tj 0 Tw (-)Tj 0.04 Tw T* (\035\017\n\031\n\026\002 \017)Tj /Span<>> BDC ( )Tj EMC (\031\f\021\036\022\017\027\031\n\026\002 \220\235\235\036\022\021\017\r\027\ \036\036 \006\036\030\021\024\035\017\031\n\026\002\026 )Tj T* (\023\220\020\024\035 \017)Tj /Span<>> BDC ( )Tj EMC (\r\036\007\024\035\017\031\n\026\002\026 [54]. \215\030\017)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\n \f\021\024\017\021 \024\021\n\036\021\017\021\034, )Tj 0.031 Tw 0 -1.218 TD (\004\021\024 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\035\033\n\017\027\026\035\034\027\024\005 \235\024\030\n\036 \207\025 \r\ \f\036 \206\224\207\215 \023\030\017\002\035\017\017)Tj 0 Tw (-)Tj 0.08 Tw 0 -1.218 TD (\021\036\035\034\027\024 \f\024\023\024\f\021\026\r\017\n\t \023\024)Tj /Span<>> BDC ( )Tj EMC (\220\235\235\036\022\021\017\r\027\024\f\021\017, \027\024 \224\203\205,\ \022\026\022 )Tj 0.051 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC 0.801 0 Td [(\023\030\024\004\017\036 )0.5(\017\027\020\017\002\017\021\024\030\t )0.5(\205\203\210-\026\035\034\235\026 )0.5(\002\024\035\036\036 )0.6(\220\235\235\036\022\021\017\r\027\t )]TJ 0 Tw -0.801 -1.218 Td (\r)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\r\024\005 \035\017\027\017\017 \021\036\030\026\023\017\017\ [55,56].)Tj -0.008 Tc 0.052 Tw T* (\200 \024\021\027\024\001\036\027\017\017 \220\235\235\036\022\021\017\r\ \027\024\f\021\017 \224\203\205 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\f\021\030\017\022\021\031\030\017\030\031\033)Tj 0 Tc 0 Tw (-)Tj -0.008 Tc 0.092 Tw T* (\013\036\n \235\036\027\024\021\017\023\036 \207\025 \024\007\027\024\027\ \026\004\027\t\b \007\026\027\027\t\b \027\036\021. \200)Tj /Span<>> BDC ( )Tj EMC (\017\f\f\035\036)Tj 0 Tc 0 Tw (-)Tj -0.008 Tc 0.089 Tw 0 -1.218 TD (\007\024\r\026\027\017\017 \f)Tj /Span<>> BDC ( )Tj EMC [(\031\004\026\f\021\017\036\n 59 \023\026\006\017\036\027\021\024\r \f\024\ \f\021\036\027\024\017\030\031\033\013\017\n)-8( )]TJ -0.047 Tw 0 -1.218 TD (\235\036\027\024\021\017\023\024\n \207\025, \031\f\023\036\b \021\036\030\ \026\023\017\017 \224\203\205 \002\t\035 \007\024\f\021\017\020\027\031\021\ \021\024\035\034)Tj 0 Tc 0 Tw (-)Tj -0.008 Tc 0.04 Tw 0 -1.218 TD (\022\024 \031)Tj /Span<>> BDC ( )Tj EMC (30% \023\026\006\017\036\027\021\024\r [57], \026)Tj /Span<>> BDC ( )Tj EMC [(\r \f\017\f\021\036\n\026\021\017\004\036\f\022\024\n \024\002\024\030\036\ )-8( )]TJ 0.11 Tw T* [(\035\017\021\036\030\026\021\031\030\t \027\036 \r\t\016\r\035\036\027\024\ \002\024\035\036\036 \031\f\023\036\001\027\024\020\024 \023\030\036\023\ \026\030\026\021\026)-8( )]TJ 0 Tw T* (\007\035\016 \035\036\004\036\027\017\016 \235\017\002\030\024\f\021\036\ \027\024\017\030\031\033\013\036\005 \235\024\030\n\t \207\025 [58].)Tj 0 Tc 0.137 Tw T* (\200 \027\026\f\021\024\016\013\036\036 \r\030\036\n\016 \224\203\205 \016\ \r\035\016\036\021\f\016 \027\026\017\002\024\035\036\036 \220\235\235\036\ \022)Tj 0 Tw (-)Tj 0.42 Tw T* (\021\017\r\027\t\n \023\030\036\023\026\030\026\021\024\n \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\035\036\004\036\027\017\017 \023\036\027\036\021\030\017\030\031\033\013\ \036\005 )Tj 0.11 Tw T* (\235\024\030\n\t \207\025 [59]. \200)Tj /Span<>> BDC ( )Tj EMC (\017\f\f\035\036\007\024\r\026\027\017\017 \f)Tj /Span<>> BDC ( )Tj EMC (\031\004\026\f\021\017\036\n 156 \023\026)Tj 0 Tw (-)Tj 0.08 Tw T* (\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\023\036\027\036\021\030\017\030\031\033\013\036\005 \235\024\030\n\024\005\ \207\025, \023\030\024\b\024\007\017\r\001\017\b )Tj 0.016 Tw T* (\035\036\004\036\027\017\036 \224\203\205, \026)Tj /Span<>> BDC ( )Tj EMC (3,5 \020\024\007\026 \027\026\002\035\033\007\036\027\017\016 \002\t\035\ \024 \024\023\036\030\017\030\024)Tj 0 Tw (-)Tj 0.069 Tw T* (\r\026\027\024 43,6% \023\026\006\017\036\027\021\024\r. \205\026\022\021\ \024\030\026\n\017 \027\036\220\235\235\036\022\021\017\r\027\024\f\021\017\ )Tj T* (\021\036\030\026\023\017\017 \023\024\f\035\031\032\017\035\024 \027\026\ \035\017\004\017\036 \026\002\f\006\036\f\f\026 \027\026)Tj /Span<>> BDC ( )Tj EMC (\n\024\n\036\027\021 \027\026)Tj 0 Tw (-)Tj 0.004 Tw T* (\004\026\035\026 \021\036\030\026\023\017\017, \225\217\207 \r\t\001\036\ 18 \n\020/\035, \031\030\024\r\036\027\034 \026\035\034\002\031\n\017\027\ \024\r )Tj 0 Tw T* (\027\017\032\036 36 \020/\035 [60].)Tj 0.048 Tw T* [(\215\030\017 \023\036\027\036\021\030\017\030\031\033\013\036\005 \235\024\ \030\n\036 )0.5(\207\025 \027\026)]TJ /Span<>> BDC ( )Tj EMC [(\f\036\020\024\007\027\016\001\027\017\005 )0.5(\007\036\027\034 )]TJ 0.12 Tw T* (\017\n\036\033\021\f\016 \007\026\027\027\t\036 \024)Tj /Span<>> BDC ( )Tj EMC (\027\026\017\035\031\004\001\036\005 \022\024\n\002\017\027\026\006\017\017\ \b\017\030\031\030\020\017)Tj 0 Tw (-)Tj 0.211 Tw T* (\004\036\f\022\024\020\024 \007\030\036\027\017\030\024\r\026\027\017\016\ \017)Tj /Span<>> BDC ( )Tj EMC (\021\036\030\026\023\017\017 \224\203\205 \017\035\017 \031\f\021\036\022\ \017)Tj 0 Tw (-)Tj 0.318 Tw T* (\027\031\n\026\002\024\n. \225\021\024\017\021 \024\021\n\036\021\017\021\ \034, \004\021\024 \004\026\f\021\024\021\026 \026\032\017\r\035\036\027\ \017\016 )Tj 0.294 Tw T* [(\f\r\017\013\036\005 )0.6(\023\030\016\n\024 )0.5(\022\024\030\030\036\035\017\030\031\036\021 )0.6(\f)]TJ /Span<>> BDC ( )Tj EMC 13.399 0 Td [(\022\024\027\006\036\027\021\030\026\006\017\036\005 )0.6(\224\203\205 )]TJ 0 Tw -13.399 -1.218 Td ([61\22664].)Tj /T1_1 1 Tf 0 -2.436 TD (\222\r\213\002\212\004\217\b\002\217\003\001)Tj /T1_0 1 Tf 0.268 Tw 0 -1.218 TD (\025\026\022 \017)Tj /Span<>> BDC ( )Tj EMC (\035\033\002\026\016 \007\030\031\020\026\016 \017\n\n\031\027\024\f\031\ \023\030\036\f\f\017\r\027\026\016 \021\036\030\026\023\017\016, )Tj 0.175 Tw T* (\035\036\004\036\027\017\036 \224\203\205 \027\036\f\036\021 \r)Tj /Span<>> BDC ( )Tj EMC (\f\036\002\036 \030\017\f\022\017 \030\026\r\017\021\017\016 \030\026\035\ \017\004)Tj 0 Tw (-)Tj 0.187 Tw T* (\027\t\b \027\036\032\036\035\026\021\036\035\034\027\t\b \016\r\035\036\ \027\017\005, \f\r\016\026\027\027\t\b \f)Tj /Span<>> BDC ( )Tj EMC (\002\036\024\023\026\f)Tj 0 Tw (-)Tj 0.077 Tw T* (\027\024\f\021\034\033 \023\026\006\017\036\027\021\026. \200)Tj /Span<>> BDC ( )Tj EMC (\030\036\026\035\034\027\024\005 \022\035\017\027\017\004\036\f\022\024\005\ \023\030\026\022\021\017\022\036 )Tj 0.107 Tw T* (\030\026\002\024\021\027\017\022\017 \007\030\026\r\024\024\b\030\026\027\ \036\027\017\016 \r\t\027\031\032\007\036\027\t \035\026\r\017\030\024\r\ \026\021\034 )Tj 0.225 Tw T* [(\n\036\032\007\031 \024\022\026\026\027\017\036\n \023\026\006\017\036\027\ \021\031 )0.5(\027\036\024\002\b\024\007\017\n\024\005 \n\036\007\017\006\017\027)]TJ 0 Tw (-)Tj -0.006 Tw T* (\f\022\024\005 \023\024\n\024\013\017 \017)Tj /Span<>> BDC ( )Tj EMC (\r\024\023\030\024\f\026\n\017 \036\201 \002\036\024\023\026\f\027\024\f\ \021\017. \225\021\024\017\021 \024\021)Tj 0 Tw (-)Tj 0.012 Tw T* (\n\036\021\017\021\034, \004\021\024 \030\017\f\022 \035\036\021\026\035\ \034\027\024\020\024 \017\f\b\024\007\026 \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\207\025, )Tj 0.011 Tw T* (\027\026\b\024\007\016\013\017\b\f\016 \027\026)Tj /Span<>> BDC ( )Tj EMC (\021\036\030\026\023\017\017 \017\027\020\017\002\017\021\024\030\026\n\017\ \205\203\210 \027\026\004\017\n\024 )Tj 0.192 Tw T* [(\027\017\032\036, )0.5(\004\036\n )0.5(\031)]TJ /Span<>> BDC ( )Tj EMC 5.565 0 Td [(\023\026\006\017\036\027\021\024\r, )0.5(\027\026\b\024\007\016\013\017\b\f\016 )0.5(\220\023\017\024\007\017\004\036\f\022\017 )]TJ 0 Tw -5.565 -1.218 Td (\017\035\017 \023\024\f\021\024\016\027\027\024 \027\026)Tj /Span<>> BDC ( )Tj EMC (\021\036\030\026\023\017\017 \f\206\025\225 [65].)Tj 0.209 Tw T* (\224\203\205 \017\n\n\031\027\024\020\036\027\027\t\005 \023\030\036\023\ \026\030\026\021, \r)Tj /Span<>> BDC ( )Tj EMC (\f\r\016\017 \f)Tj /Span<>> BDC ( )Tj EMC (\220\021\017\n \030\017\f\022 )Tj 0.403 Tw T* [(\030\036\026\022\006\017\017 \020\017\023\036\030\004\031\r\f\021\r\017\021\ \036\035\034\027\024\f\021\017 )0.5(\027\026)]TJ /Span<>> BDC ( )Tj EMC (\235\024\027\036 \021\036\030\026\023\017\017 )Tj 0.296 Tw T* (\f\030\026\r\027\017\021\036\035\034\027\024 \f)Tj /Span<>> BDC ( )Tj EMC (\007\030\031\020\017\n\017 \206\224\207\215 \007\024\r\024\035\034\027\024\ \r\t\f\024\022\017\005. )Tj 0.174 Tw T* (\200)Tj /Span<>> BDC ( )Tj EMC (\017\f\f\035\036\007\024\r\026\027\017\017 \f)Tj /Span<>> BDC ( )Tj EMC (\031\004\026\f\021\017\036\n 91 \023\026\006\017\036\027\021\026 \f)Tj /Span<>> BDC ( )Tj EMC (\017\n\n\031\027\024)Tj 0 Tw (-)Tj 0.336 Tw T* [(\r\024\f\023\026\035\017\021\036\035\034\027\t\n\017 )0.5(\026\002\024\035\036\r\026\027\017\016\n\017, \026\027\021\017\021\036\035\ \026 )0.5(\022)]TJ /Span<>> BDC ( )Tj EMC (\023\030\036)Tj 0 Tw (-)Tj 0.293 Tw T* (\023\026\030\026\021\031 \r\t\016\r\035\016\035\017\f\034 \r)Tj /Span<>> BDC ( )Tj EMC (\021\036\004\036\027\017\036 \020\024\007\026 \027\036\026\r\017\f\017\n\ \024 \024\021 )Tj 0.428 Tw T* (\021\017\023\026 \017\n\n\031\027\024\r\024\f\023\026\035\017\021\036\035\ \034\027\024\020\024 \026\002\024\035\036\r\026\027\017\016. \200)Tj /Span<>> BDC ( )Tj EMC (\002\024)Tj 0 Tw (-)Tj 0.477 Tw T* [(\035\036\036 \r\t\f\024\022\024\005 \022\024\027\006\036\027\021\030\026\ \006\017\017 )0.5(\r\t\016\r\035\016\035\017\f\034 \026\027\021\017\021\036\035\026 )]TJ 0.249 Tw T* (\022\035\026\f\f\026 IgE, \017)Tj /Span<>> BDC ( )Tj EMC (\017\n\036\027\027\024 \024\027\017 \024\002\031\f\035\026\r\035\017\r\026\ \035\017 \030\036\026\022\006\017\033 )Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0 Tw 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\205)10(\210\036\033 \035\030\032\204\033)30(\021)42(\032)-21(\211\033\237)]TJ 57.136 0 Td (REVIEW)Tj -57.136 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 23, \023\0222, 202)69(4)]TJ 42.99 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 23, \023\0222, 202)69(4)]TJ /T1_3 1 Tf 25 0 0 25 20.8526 56.0378 Tm (178)Tj ET endstream endobj 499 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\021\017)-10(\026)-19.9(\002\016\b\206\004\016 \b\005 \026)11.1(\t\235\016\225\005\200 \005\004\232\b\005\017\r\005\024\016\213\025\024 \ \f\022\004\016\r)-9.9(\026)11(\025\200\221\t\t \f\235\t\024\200 \002\022\225\016\255\005\t\004\026)11(\025\f )]TJ 0 -1 TD [(\r\022\f\025\r\225\016\b\005\026)11(\t\b\206\004\007\024\005 \220\016\213\025\b\t\f\016\004\005\200\024\005 \ \017\005\203\t\020\004\005\017\016? $\025\213\220\025\235 \b\005\026)11(\t\235\016\026)-20(\002\235\007$)]TJ 41.079 1 Td [(Is infliximab th)11(er)21(apy curr)31(ently r)31(ele)11(v)10(ant in patients )]TJ 2.1 -1 Td [(with inflammator)-30.9(y bow)11(el diseases? $r)31(e)11(vie)11(w$)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0.106 Tw 10 0 0 10 42.5197 724.8299 Tm (\023\030\036\023\026\030\026\021\026 \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\026\b, \023\024\035\031\004\026\r\001\017\b \022\024\ \n\002\017\027\017\030\024\r\026\027\027\031\033 )Tj 0 Tw 0 -1.218 TD (\021\036\030\026\023\017\033 \f)Tj /Span<>> BDC ( )Tj EMC (\021\017\024\023\031\030\017\027\026\n\017 [31\22634].)Tj 0.155 Tw T* [(\213\013\201 )0.5(\024\007\027\017\n )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 6.329 0 Td [(\f\023\024\f\024\002\024\r )0.5(\023\024\r\t\001\036\027\017\016 )0.6(\220\235\235\036\022\021\017\r\027\024\f\021\017 )]TJ 0.103 Tw -6.329 -1.218 Td (\224\203\205 \016\r\035\016\036\021\f\016 \220\f\022\026\035\026\006\017\ \016 \007\024\t. \210\027\026 \r\024\n\024\032\027\026 \023\031\021\036\ \n )Tj 0.007 Tw T* (\031\r\036\035\017\004\036\027\017\016 \007\024\t \023\030\036\023\026\030\ \026\021\026 \017\035\017 \f\024\022\030\026\013\036\027\017\036\n \017\027\ \021\036\030)Tj 0 Tw (-)Tj 0.134 Tw T* (\r\026\035\024\r \r\r\036\007\036\027\017\005. \200)Tj /Span<>> BDC ( )Tj EMC 8.252 0 Td [(\f\017\f\021\036\n\026\021\017\004\036\f\022\024\n )0.5(\026\027\026\035\017\036 )0.5(68)]TJ /Span<>> BDC ( )Tj EMC (\024\002)Tj 0 Tw (-)Tj 0.468 Tw -8.252 -1.218 Td (\f\036\030\r\026\006\017\024\027\027\t\b \017\f\f\035\036\007\024\r\026\027\ \017\005 \023\024\022\026\026\027\024 \024\021\f\031\021\f\021\r\017\036\ )Tj 0.25 Tw T* (\030\026\027\017\006\t \n\036\032\007\031 \031\r\036\035\017\004\036\027\ \017\036\n \007\024\t \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\022\030\026\013\036\027\017\036\n )Tj 0.161 Tw T* (\017\027\021\036\030\r\026\035\024\r [35]. \210\023\021\017\n\017\017\030\ \024\r\026\027\027\t\005 \023\024)Tj /Span<>> BDC ( )Tj EMC (\f\030\024\022\026\n \030\036)Tj 0 Tw (-)Tj 0.072 Tw T* (\032\017\n \r\r\036\007\036\027\017\016 \224\203\205 \021\026\022\032\036\ \220\235\235\036\022\021\017\r\036\027, \022\026\022 \017)Tj /Span<>> BDC ( )Tj EMC (\022\024\n\002\017)Tj 0 Tw (-)Tj 0.182 Tw T* [(\027\017\030\024\r\026\027\027\026\016 )0.6(\021\036\030\026\023\017\016. )0.5(\210\007\027\026\022\024 )0.6(\023\024\f\035\036 )0.5(\024\021\n\036\027\t )0.5(\026\026\021\017\024)]TJ /Span<>> BDC (-)Tj EMC 0.248 Tw T* (\023\030\017\027\026 \017\f\b\024\007\t \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \b\031\032\036, \004\036\n \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r )Tj 0 Tw 0 -1.218 TD (\027\026)Tj /Span<>> BDC ( )Tj EMC (\n\024\027\024\021\036\030\026\023\017\017 [36].)Tj 0.103 Tw 0 -1.218 TD [(\231\026\022\032\036 )0.5(\017\n\036\033\021\f\016 )0.6(\024\020\030\026\027\017\004\036\027\027\t\036 )0.5(\007\026\027\027\t\036 )0.6(\024\002 )0.5(\220\235\235\036\022\021\017\r)]TJ 0 Tw (-)Tj 0.183 Tw 0 -1.218 TD (\027\024\f\021\017 \030\036\017\027\007\031\022\006\017\017 \224\203\205\ \r\024 \r\030\036\n\016 \023\024\007\007\036\030\032\017\r\026\033\013\036\ \005 )Tj 0.037 Tw T* (\021\036\030\026\023\017\017 \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r, \007\036\n\024\027\f\021\030\017\030\ \031\033\013\017\b \022\035\017\027\017\022\024-\035\026)Tj 0 Tw (-)Tj 0.016 Tw T* (\002\024\030\026\021\024\030\027\t\036 \023\030\017\027\026\022\017 \023\ \024\021\036\030\017 \024\021\r\036\021\026. \215\030\017)Tj /Span<>> BDC ( )Tj EMC (\030\036\021\030\024\f\023\036\022)Tj 0 Tw (-)Tj -0.046 Tw T* (\021\017\r\027\024\n \026\027\026\035\017\036 80 \f\035\031\004\026\036\ \r \207\025 \f)Tj /Span<>> BDC ( )Tj EMC (\023\024\021\036\030\036\005 \024\021\r\036\021\026 \021\026\022\021\017\ )Tj 0 Tw (-)Tj 0.07 Tw T* (\022\026 \030\036\017\027\007\031\022\006\017\017 \002\t\035\026 \f\024\023\ \024\f\021\026\r\017\n\026 \023\024)Tj /Span<>> BDC ( )Tj EMC (\220\235\235\036\022\021\017\r\027\024\f\021\017 )Tj 0 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\220\f\022\026\035\026\006\017\036\005 \007\024\t [37].)Tj 0.015 Tw T* (\200\026\032\027\024\036 \n\036\f\021\024 \r)Tj /Span<>> BDC ( )Tj EMC (\024\023\021\017\n\017\026\006\017\017 \021\036\030\026\023\017\017 \224\ \203\205 \026\027\017\n\026\033\021 )Tj 0.341 Tw T* (\235\026\030\n\026\022\024\022\017\027\036\021\017\004\036\f\022\017\036\ \r\024\023\030\024\f\t. \200)Tj /Span<>> BDC ( )Tj EMC (\f\035\024\r\036\027\f\022\024\n \017\f)Tj 0 Tw (-)Tj 0.128 Tw T* (\f\035\036\007\024\r\026\027\017\017 \f)Tj /Span<>> BDC ( )Tj EMC (\031\004\026\f\021\017\036\n 109 \023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\207\025 \023\024\022\026\026)Tj 0 Tw (-)Tj 0.132 Tw T* (\027\024, \004\021\024 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\f\t\r\024\030\024\021\024\004\027\024\005 \022\024\027\006\036\027\021\030\ \026\006\017\017 \224\203\205 \r\t\001\036 )Tj 0.15 Tw T* (7)Tj /Span<>> BDC ( )Tj EMC (\n\022\020/\n\035, \225\217\207 \017)Tj /Span<>> BDC ( )Tj EMC (\205\025\215 \027\026\004\017\n\024 \027\017\032\036, \004\036\n \023\030\ \017)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\036\036 )Tj -0.014 Tw T* (\027\017\022\017\b \023\035\026\n\036\027\027\t\b \022\024\027\006\036\ \027\021\030\026\006\017\016\b. \215\030\017)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\n \004\026\f\021\024\021\026 )Tj 0.128 Tw T* (\017\027\235\036\022\006\017\024\027\027\t\b \024\f\035\024\032\027\036\027\ \017\005 \002\t\035\026 \f\024\023\024\f\021\026\r\017\n\026 [38]. )Tj 0.182 Tw T* [(Syver)-9.9(sen)]TJ /Span<>> BDC ( )Tj EMC (S.W. \017 \f\024\026\r\021. \023\030\024\r\036\035\017 \026\027\026\035\017\ \017\f\b\024\007\024\r \021\036)Tj 0 Tw (-)Tj 0.181 Tw T* (\030\026\023\017\017 \224\203\205 \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\017\n\n\031\027\024\r\024\f\023\026\035\017\021\036\035\034\027\t\n\017\ )Tj 0.405 Tw T* [(\026\002\024\035\036\r\026\027\017\016\n\017 )0.5($\200\003\025, \023\f\024\030\017\026, \002\024\035\036\027\034 \207\036\ \b\021\036\030\036\r\026 )]TJ 0.209 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC [(\023\030.$. )0.5(\210\007\027\024\005 \020\030\031\023\023\036 )0.5(\023\030\024\r\024\007\017\035\f\016 )0.5(\023\030\024\026\022\021\017\r\027\t\005 \035\036)]TJ 0 Tw (-)Tj 0.11 Tw T* [(\022\026\030\f\021\r\036\027\027\t\005 )0.6(\n\024\027\017\021\024\030\017\027\020, )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 11.951 0 Td [(\022\024\030\030\036\022\006\017\016 )0.5(\021\036\030\026\023\017\017 )0.6(\024\f\031)]TJ 0 Tw (-)Tj 0.288 Tw -11.951 -1.218 Td (\013\036\f\021\r\035\016\035\026\f\034, \017\f\b\024\007\016 \017)Tj /Span<>> BDC ( )Tj EMC (\023\035\026\n\036\027\027\t\b \022\024\027\006\036\027\021\030\026\006\ \017\005 )Tj 0.493 Tw T* (\023\030\036\023\026\030\026\021\024\r \017)Tj /Span<>> BDC ( )Tj EMC [(\027\026\035\017\004\017\016 \027\036\005\021\030\026\035\017\031\033\013\ \017\b )0.5(\026\027\021\017\021\036\035. )]TJ 0.175 Tw T* (\212\030\031\020\024\005 \020\030\031\023\023\036 \022\024\030\030\036\022\ \006\017\016 \021\036\030\026\023\017\017 \023\030\024\r\024\007\017\035\ \026\f\034 \017\f)Tj 0 Tw (-)Tj 0.157 Tw T* (\b\024\007\016 \017)Tj /Span<>> BDC ( )Tj EMC [(\021\030\026\007\017\006\017\024\027\027\t\b )0.5(\022\035\017\027\017\004\036\f\022\017\b )0.5(\017\027\007\036\022\f\024\r \017)]TJ /Span<>> BDC ( )Tj EMC (\035\026)Tj 0 Tw (-)Tj 0.465 Tw T* (\002\024\030\026\021\024\030\027\t\b \023\024\022\026\026\021\036\035\036\ \005 \r\024\f\023\026\035\017\021\036\035\034\027\024\020\024 \024\021\r\ \036\021\026. )Tj 0.196 Tw T* (\224\f\f\035\036\007\024\r\026\021\036\035\017 \023\024\022\026\026\035\ \017, \004\021\024 \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \231\214\204 \017\f\b\024\007\t )Tj 0.145 Tw T* (\002\t\035\017 \035\031\004\001\036 [39]. \200)Tj /Span<>> BDC ( )Tj EMC (\007\030\031\020\024\n \235\026\030\n\026\022\017\027\036\021\017\004\036\ \f\022\024\n \017\f)Tj 0 Tw (-)Tj 0.074 Tw T* (\f\035\036\007\024\r\026\027\017\017 \023\024\022\026\026\027\024, \004\ \021\024 \023\035\026\n\036\027\027\026\016 \022\024\027\006\036\027\021\ \030\026\006\017\016 )Tj 0.095 Tw T* (\224\203\205 \r\t\001\036 5,1 \n\022\020/\n\035 \002\t\035\026 \026\f\f\024\ \006\017\017\030\024\r\026\027\026 \f)Tj /Span<>> BDC ( )Tj EMC (\030\036\n\017\f)Tj 0 Tw (-)Tj 0.241 Tw T* [(\f\017\036\005 )0.5(\r\024\f\023\026\035\017\021\036\035\034\027\024\020\024 )0.5(\023\030\024\006\036\f\f\026 \031)]TJ /Span<>> BDC ( )Tj EMC [(\023\026\006\017\036\027\021\024\r )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC (\207\025, )Tj 0.181 Tw T* (\026)Tj /Span<>> BDC ( )Tj EMC (\r\t\f\024\022\026\016 \022\024\027\006\036\027\021\030\026\006\017\016 \ \026\027\021\017\021\036\035 \022)Tj /Span<>> BDC ( )Tj EMC (\023\030\036\023\026\030\026\021\031 \002\t\035\026 )Tj 0.239 Tw T* (\026\f\f\024\006\017\017\030\024\r\026\027\026 \f)Tj /Span<>> BDC ( )Tj EMC (\027\017\022\024\005 \022\024\027\006\036\027\021\030\026\006\017\036\005\ \023\030\036\023\026\030\026\021\026 )Tj 0.057 Tw T* ([40]. \200)Tj /Span<>> BDC ( )Tj EMC (\030\036\021\030\024\f\023\036\022\021\017\r\027\024\n \026\027\026\035\017\ \036 \f)Tj /Span<>> BDC ( )Tj EMC (\031\004\026\f\021\017\036\n 226)Tj /Span<>> BDC ( )Tj EMC (\023\026)Tj 0 Tw (-)Tj 0.185 Tw T* (\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\200\003\025 \023\024\022\026\026\027\024, \004\021\024 \023\030\036\022\ \030\026\013\036\027\017\036 \021\036\030\026\023\017\017 )Tj 0.031 Tw T* (\224\203\205 \027\026)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\r\024\n \020\024\007\031 \023\024\007\007\036\030\032\017\r\ \026\033\013\036\005 \021\036\030\026\023\017\017 \002\t\035\024 )Tj 0.134 Tw T* (\027\026\004\017\n\024 \r\t\001\036 \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \023\026\006\017\036\027\021\024\r, \r)Tj /Span<>> BDC ( )Tj EMC (\022\024\021\024\030\024\005 \024\023\021\017)Tj 0 Tw (-)Tj 0.214 Tw T* [(\n\017\026\006\017\016 )0.6(\024\f\031\013\036\f\021\r\035\016\035\026\f\034 )0.6(\f)]TJ /Span<>> BDC ( )Tj EMC 11.832 0 Td [(\031\004\036\021\024\n )0.5(\021\024\035\034\022\024 )0.6(\022\035\017\027\017\022\024-)]TJ 0.188 Tw -11.832 -1.218 Td (\017\027\f\021\030\031\n\036\027\021\026\035\034\027\t\b \n\036\021\024\007\ \017\022 \022\024\027\021\030\024\035\016, \002\036 \235\026\030\n\026\022\ \024)Tj 0 Tw (-)Tj 0.244 Tw T* (\022\017\027\036\021\017\004\036\f\022\024\020\024 \026\027\026\035\017\ \026 [41]. \025\030\024\n\036 \021\024\020\024, \026\022\021\017\r\027\024\ \036 )Tj 0.178 Tw T* (\023\024\007\007\036\030\032\026\027\017\036 \023\035\026\n\036\027\027\ \024\005 \022\024\027\006\036\027\021\030\026\006\017\017 \224\203\205 \r\ \t\001\036 )Tj 0.271 Tw T* [(3 )0.5(\n\022\020/\035 )0.5(\027\026\004\017\n\024 )0.5(\031\r\036\035\017\004\017\r\026\036\021 )0.5(\r\t\032\017\r\026\036\n\024\f\021\034 )0.5(\021\036\030\026)]TJ 0 Tw (-)Tj 0.015 Tw T* (\023\017\017 \027\026)Tj /Span<>> BDC ( )Tj EMC 3.006 0 Td [(\023\030\024\021\016\032\036\027\017\017 )0.5(1 \020\024\007\026 \023\024\007\007\036\030\032\017\r\026\033\013\036\005\ )0.5(\021\036\030\026\023\017\017 )]TJ -0.022 Tw 20.238 64.543 Td ([42]. \200)Tj /Span<>> BDC ( )Tj EMC (\030\036\021\030\024\f\023\036\022\021\017\r\027\024\n \026\027\026\035\017\ \036 238 \023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\207\025, )Tj 0.163 Tw T* (\027\026\b\024\007\016\013\017\b\f\016 \027\026)Tj /Span<>> BDC ( )Tj EMC (\021\036\030\026\023\017\017 \224\203\205, \021\036\030\026\023\036\r\021\ \017\004\036\f\022\017\005 \035\036)Tj 0 Tw (-)Tj 0.195 Tw T* (\022\026\030\f\021\r\036\027\027\t\005 \n\024\027\017\021\024\030\017\027\ \020 \023\024\r\024\035\017\035 \f\027\017\017\021\034 \004\026\f\021\024\ \021\031 )Tj 0.414 Tw T* (\b\017\030\031\030\020\017\004\036\f\022\024\020\024 \035\036\004\036\027\ \017\016 \f\030\026\r\027\017\021\036\035\034\027\024 \f)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\024\005, )Tj 0.05 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\022\024\021\024\030\024\005 \220\021\024\021 \023\024\007\b\024\007 \027\ \036 \023\030\017\n\036\027\016\035\f\016 [43]. \200)Tj /Span<>> BDC ( )Tj EMC (\007\030\031\020\024\n )Tj 0.233 Tw T* (\017\f\f\035\036\007\024\r\026\027\017\017 \f)Tj /Span<>> BDC ( )Tj EMC (\031\004\026\f\021\017\036\n 81 \023\026\006\017\036\027\021\026 \f)Tj /Span<>> BDC ( )Tj EMC (\200\003\025, \023\030\024)Tj 0 Tw (-)Tj 0.455 Tw 0 -1.218 TD [(\026\022\021\017\r\027\t\005 )0.5(\035\036\022\026\030\f\021\r\036\027\027\t\005 )0.6(\n\024\027\017\021\024\030\017\027\020 )0.6(\023\035\026\n\036\027\027\024\005 )]TJ 0.053 Tw 0 -1.218 TD [(\022\024\027\006\036\027\021\030\026\006\017\017 \017\027\235\035\017\022\ \f\017\n\026\002\026 )0.5(\f\027\017\032\026\035 \030\017\f\022 \027\036\220\235\235\036\022)]TJ 0 Tw (-)Tj 0.436 Tw T* (\021\017\r\027\024\f\021\017 \021\036\030\026\023\017\017, \027\036\024\002\ \b\024\007\017\n\024\f\021\017 \b\017\030\031\030\020\017\004\036\f\022\024\ \020\024 )Tj 0 Tw T* (\035\036\004\036\027\017\016 \017)Tj /Span<>> BDC ( )Tj EMC (\f\036\030\034\036\027\t\b \027\036\032\036\035\026\021\036\035\034\027\ \t\b \030\036\026\022\006\017\005 [44].)Tj 0.014 Tw T* [(\200 )0.5(\024\021\027\024\001\036\027\017\017 )0.6(\231\214\204 )0.5(\002\t\035\017 )0.6(\023\030\024\r\036\007\036\027\t )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 15.477 0 Td [(\027\036\022\024\021\024\030\t\036 )0.6(\235\026\030)]TJ 0 Tw (-)Tj -0.031 Tw -15.477 -1.218 Td [(\n\026\022\024\220\022\024\027\024\n\017\004\036\f\022\017\036 )0.6(\017\f\f\035\036\007\024\r\026\027\017\016, )0.6(\022\024\021\024\030\t\036 )0.5(\023\024\022\026\026\035\017 )]TJ 0.148 Tw 0 -1.218 TD (\002\024\035\034\001\031\033 \024\002\024\f\027\024\r\026\027\027\024\f\021\ \034 \021\026\022\024\020\024 \023\024\007\b\024\007\026 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\035\036\004\036)Tj 0 Tw (-)Tj 0.305 Tw 0 -1.218 TD (\027\017\017 \023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\017\n\n\031\027\024\r\024\f\023\026\035\017\021\036\035\034\027\t\n\017\ \026\002\024\035\036)Tj 0 Tw (-)Tj 0.106 Tw 0 -1.218 TD (\r\026\027\017\016\n\017 \206\224\207\215. \202\022\021\017\r\027\t\005 \ \231\214\204 \023\035\026\n\036\027\027\024\005 \022\024\027\006\036\027\ \021)Tj 0 Tw (-)Tj 0.115 Tw T* (\030\026\006\017\017 \224\203\205 \007\026\036\021 \r\024\n\024\032\027\ \024\f\021\034 \017\027\007\017\r\017\007\031\026\035\017\017\030\024\r\ \026\021\034 )Tj -0.021 Tw T* (\021\036\030\026\023\017\033 \017)Tj /Span<>> BDC ( )Tj EMC (\235\026\030\n\026\022\024\220\022\024\027\024\n\017\004\036\f\022\017 \002\ \024\035\036\036 \r\t\020\024\007\036\027, \004\036\n )Tj -0.003 Tw T* (\024\023\021\017\n\017\026\006\017\016 \021\036\030\026\023\017\017 \027\ \026)Tj /Span<>> BDC ( )Tj EMC (\024\f\027\024\r\026\027\017\017 \024\f\027\024\r\027\t\b \022\035\017\027\ \017)Tj 0 Tw (-)Tj T* (\022\024-\035\026\002\024\030\026\021\024\030\027\t\b \023\024\022\026\026\ \021\036\035\036\005 [45].)Tj 0.115 Tw T* (\211 \023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\200\003\025 \231\214\204 \017\n\036\036\021 \r\026\032\027\024\036 \027\ \026\004\036\027\017\036, \021\026\022 )Tj 0.023 Tw T* [(\022\026\022 \023\024\r\024\035\016\036\021 \024\023\021\017\n\017\017\ \030\024\r\026\021\034 )0.5(\021\036\030\026\023\017\033 \022\024\027\022\030\036\021\027\024\n\031 \ )]TJ 0.144 Tw T* (\023\026\006\017\036\027\021\031. \230\021\024\021 \f\023\024\f\024\002 \ \235\026\030\n\026\022\024\220\022\024\027\024\n\017\004\036\f\022\017 \002\ \024\035\036\036 )Tj 0.295 Tw T* [(\r\t\020\024\007\036\027, )0.5(\004\036\n )0.5(\024\023\021\017\n\017\026\006\017\016 )0.6(\021\036\030\026\023\017\017 )0.6(\017\f\b\024\007\016 )0.5(\021\024\035\034\022\024 )]TJ 0.478 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC [(\022\035\017\027\017\022\024-\017\027\f\021\030\031\n\036\027\021\026\035\ \034\027\t\b )0.5(\007\026\027\027\t\b. \215\030\017)]TJ /Span<>> BDC ( )Tj EMC (\017\027\017)Tj 0 Tw (-)Tj 0.314 Tw T* (\006\017\026\006\017\017 \021\036\030\026\023\017\017 \023\030\017\n\036\ \027\016\036\021\f\016 \030\036\026\022\021\017\r\027\t\005 \n\024\027\017\ \021\024)Tj 0 Tw (-)Tj 0.072 Tw T* (\030\017\027\020)Tj /Span<>> BDC ( )Tj EMC 2.205 0 Td [(\227 )0.5(\030\026\f\004\036\021 )0.5(\007\024\t )0.6(\023\030\024\017\r\024\007\017\021\f\016 )0.6(\r)]TJ /Span<>> BDC ( )Tj EMC 13.477 0 Td [(\026\r\017\f\017\n\024\f\021\017 )0.6(\024\021 )]TJ 0.052 Tw -15.683 -1.218 Td [(\023\035\026\n\036\027\027\024\005 )0.6(\022\024\027\006\036\027\021\030\026\006\017\017 )0.5(\224\203\205, )0.6(\006\036\035\034)]TJ /Span<>> BDC ( )Tj EMC 15.875 0 Td [(\227 )0.5(\007\024\f\021\017\032\036\027\017\036 )]TJ -0.018 Tw -15.875 -1.218 Td (\r\t\f\024\022\024\020\024 \031\030\024\r\027\016. \203\026)Tj /Span<>> BDC ( )Tj EMC (\235\024\027\036 \023\024\007\007\036\030\032\017\r\026\033\013\036\005 \ \021\036\030\026\023\017\017 )Tj 0.322 Tw T* (\023\030\017\n\036\027\016\036\021\f\016 \023\030\024\026\022\021\017\r\027\ \t\005 \023\036\030\017\024\007\017\004\036\f\022\017\005 \n\024\027\017\ \021\024)Tj 0 Tw (-)Tj 0.141 Tw T* (\030\017\027\020, \006\036\035\034 \022\024\021\024\030\024\020\024 \f\024\ \f\021\024\017\021 \r)Tj /Span<>> BDC ( )Tj EMC (\027\036\024\002\b\024\007\017\n\024\f\021\017 \022\024\027\021)Tj 0 Tw (-)Tj 0.18 Tw T* (\030\024\035\016 \027\026)Tj /Span<>> BDC ( )Tj EMC (\235\024\027\036 \023\024\007\007\036\030\032\022\017 \026\007\036\022\r\ \026\021\027\024\020\024 \023\035\026\n\036\027\027\024\020\024 )Tj 0 Tw T* (\031\030\024\r\027\016 \023\030\036\023\026\030\026\021\026 [46].)Tj /T1_2 1 Tf 0 -2.436 TD (\200\r\006\r\220\f\211\201\r\b\t\r \214\r\202\240\210 \206\t\002\217\t\214\ \t\f\235\006\004\214\t)Tj /T1_1 1 Tf 0.012 Tc -0.015 Tw 0 -1.218 TD [(\200 \023\024\f\035\036\007\027\036\036 \r\030\036\n\016 \023\036\030\036\ \007 \020\026\f\021\030\024\220\027\021\036\030\024\035\024\020\026\n\017\ \024\f\021\030\024)12( )]TJ 0.369 Tw T* (\r\f\021\026\036\021 \023\030\024\002\035\036\n\026 \023\036\030\036\022\ \035\033\004\036\027\017\016 \f)Tj /Span<>> BDC ( )Tj EMC [(\024\030\017\020\017\027\026\035\034\027\024\020\024)12( )]TJ -0.048 Tw T* (\206\224\207\215 \027\026)Tj /Span<>> BDC ( )Tj EMC (\002\017\024\f\017\n\017\035\016\030\t \017-\026 \f\024\n\027\036\027\017\ \005 \r)Tj /Span<>> BDC ( )Tj EMC (\017\b \002\017\024\220\022\r\017)Tj 0 Tc 0 Tw (-)Tj 0.012 Tc 0.169 Tw T* [(\r\026\035\036\027\021\027\024\f\021\017 \024\030\017\020\017\027\026\035\ \034\027\t\n \023\030\036\023\026\030\026\021\026\n. \215\030\017\027\017\ \n\026\016)12( )]TJ 0.302 Tw T* [(\r\024 \r\027\017\n\026\027\017\036 \f\035\024\032\027\031\033 \f\021\030\ \031\022\021\031\030\031 \n\024\035\036\022\031\035\t \206\224\207\215)12( )]TJ 0.467 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC [(\002\017\024\035\024\020\017\004\036\f\022\017\005 \n\036\021\024\007 \023\ \030\024\017\r\024\007\f\021\r\026, \007\024\002\017\021\034\f\016)11.9( )]TJ 0.128 Tw T* (\023\024\035\027\024\020\024 \b\017\n\017\004\036\f\022\024\020\024 \f\024\ \024\021\r\036\021\f\021\r\017\016 \023\030\036\023\026\030\026\021\024\r\ \027\036)Tj 0 Tc 0 Tw (-)Tj 0.012 Tc 0.178 Tw T* (\r\024\n\024\032\027\024. \200)Tj /Span<>> BDC ( )Tj EMC (\f\r\016\017 \f)Tj /Span<>> BDC ( )Tj EMC (\220\021\017\n \007\024\r\024\035\034\027\024 \n\027\024\020\024 \017\f\f\ \035\036)Tj 0 Tc 0 Tw (-)Tj 0.012 Tc 0.184 Tw T* (\007\024\r\026\027\017\005 \r)Tj /Span<>> BDC ( )Tj EMC (\023\024\f\035\036\007\027\036\036 \r\030\036\n\016 \023\024\f\r\016\013\ \036\027\t \220\021\024\n\031 \r\024)Tj 0 Tc 0 Tw (-)Tj 0.012 Tc 0.04 Tw T* [(\023\030\024\f\031. \225\031\013\036\f\021\r\036\027\027\t\n \024\020\030\ \026\027\017\004\036\027\017\036\n \220\022\f\021\030\026\023\024\035\016\ \006\017\017)12( )]TJ 0.017 Tw T* (\007\026\027\027\t\b \r)Tj /Span<>> BDC ( )Tj EMC [(\030\036\026\035\034\027\031\033 \022\035\017\027\017\004\036\f\022\031\033\ \023\030\026\022\021\017\022\031 \016\r\035\016\036\021\f\016)12( )]TJ 0.549 Tw T* (\030\026\027\024\030\024\007\027\024\f\021\034 \f\017\021\031\026\006\017\ \005 \023\036\030\036\022\035\033\004\036\027\017\016 \023\026\006\017\036\ \027)Tj 0 Tc 0 Tw (-)Tj 0.012 Tc 0.208 Tw T* (\021\024\r. \200)Tj /Span<>> BDC ( )Tj EMC (\027\026\f\021\024\016\013\036\036 \r\030\036\n\016 \r)Tj /Span<>> BDC ( )Tj EMC [(\217\024\f\f\017\005\f\022\024\005 \205\036\007\036\030\026\006\017\017)12( )]TJ 0.334 Tw T* (\026\030\036\020\017\f\021\030\017\030\024\r\026\027\024 3 \026\027\026\ \035\024\020\026 \224\203\205, \026)Tj /Span<>> BDC ( )Tj EMC [(\r \026\023\026\007\027\t\b)12.1( )]TJ 0.225 Tw T* (\f\021\030\026\027\026\b \021\026\022\017\b \026\027\026\035\024\020\024\ \r \002\024\035\036\036 \007\036\f\016\021\022\026. \215\024)Tj /Span<>> BDC ( )Tj EMC [(\235\026\022\021\031,)12( )]TJ 0.484 Tw T* [(\024\007\027\024 \022\024\027\022\030\036\021\027\024\036 \017\f\f\035\036\ \007\024\r\026\027\017\036 \n\024\032\036\021 \023\024\022\026\026\021\034\ )11.9( )]TJ 0.229 Tw T* (\220\235\235\036\022\021\017\r\027\024\f\021\034 \017)Tj /Span<>> BDC ( )Tj EMC (\002\036\024\023\026\f\027\024\f\021\034 \023\036\030\036\022\035\033\004\ \036\027\017\016 \023\026)Tj 0 Tc 0 Tw (-)Tj 0.012 Tc 0.045 Tw T* (\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\024\007\027\024\020\024 \022\024\027\022\030\036\021\027\024\020\024 \023\ \030\036\023\026\030\026\021\026 \027\026)Tj /Span<>> BDC ( )Tj EMC [(\007\030\031\020\024\005)12( )]TJ 0.056 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC 0.83 0 Td [(\027\036 )0.5(\n\024\032\036\021 )0.5(\002\t\021\034 )0.5(\220\022\f\021\030\026\023\024\035\017\030\024\r\026\027\024 )0.5(\027\026)]TJ /Span<>> BDC ( )Tj EMC [(\017\027\t\036 \f\035\031\004\026\017)11.9( )]TJ 0 Tw -0.83 -1.218 Td (\023\036\030\036\022\035\033\004\036\027\017\016)Tj /Span<>> BDC ( )Tj EMC ([47].)Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 0 Tc 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\205)10(\210\036\033 \035\030\032\204\033)30(\021)42(\032)-21(\211\033\237)]TJ 57.136 0 Td (REVIEW)Tj /T1_3 1 Tf 25 0 0 25 505.6144 56.0378 Tm (177)Tj ET endstream endobj 498 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 0 0 0 1 k /GS1 gs /T1_0 1 Tf -0.034 Tw 10 0 0 10 70.8661 724.8299 Tm (\035\017\027\017\005 \021\036\030\026\023\017\017 \206\224\207\215. \217\ \036\001\036\027\017\036 \220\021\024\005 \023\030\024\002\035\036\n\t \024\ \f\035\024\032)Tj 0 Tw (-)Tj -0.015 Tw 0 -1.218 TD (\027\016\036\021\f\016 \022\030\026\005\027\036\005 \020\036\021\036\030\ \024\020\036\027\027\024\f\021\034\033 \022\035\017\027\017\004\036\f\022\ \017\b \023\030\024\016\r)Tj 0 Tw (-)Tj 0.015 Tw T* (\035\036\027\017\005 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\200\003\025. \215\030\017)Tj /Span<>> BDC ( )Tj EMC (\242\025 \017)Tj /Span<>> BDC ( )Tj EMC (\207\025 \r)Tj /Span<>> BDC ( )Tj EMC (\235\024\030\n\036 \022\024\035\017\021\026 \027\036\023\035\024\b\024 )Tj 0.011 Tw T* (\023\024\022\026\026\035\017 \f\036\002\016 \022\035\017\027\017\004\036\ \f\022\017\036 \017\027\007\036\022\f\t \026\022\021\017\r\027\024\f\021\ \017 $\017\027)Tj 0 Tw (-)Tj 0.096 Tw T* (\007\036\022\f \204\036\005\024 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\242\025 \017)Tj /Span<>> BDC ( )Tj EMC (\017\027\007\036\022\f \216\026\030\r\017-\207\030\220\007\001\024\031 \023\ \030\017)Tj /Span<>> BDC ( )Tj EMC (\207\025$ )Tj 0.421 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC [(\017\027\007\036\022\f\t \220\027\007\024\f\022\024\023\017\004\036\f\022\ \024\005 \026\022\021\017\r\027\024\f\021\017, )0.5(\022\024\021\024\030\t\036 )]TJ 0.137 Tw 0 -1.218 TD (\n\024\032\027\024 \024\006\036\027\017\r\026\021\034 \024\002\255\036\022\ \021\017\r\027\024 \023\024)Tj /Span<>> BDC ( )Tj EMC (\002\026\035\035\034\027\t\n \001\022\026\035\026\n. )Tj 0.124 Tw 0 -1.218 TD (\025)Tj /Span<>> BDC ( )Tj EMC 0.915 0 Td [(\f\024\032\026\035\036\027\017\033, )0.6(\007\035\016 )0.5(\023\024\030\026\032\036\027\017\016 )0.5(\021\024\027\022\024\005 )0.6(\022\017\001\022\017 )0.5(\023\030\017)]TJ /Span<>> BDC ( )Tj EMC 20.081 0 Td (\207\025 )Tj 0.69 Tw -20.996 -1.218 Td [(\220\021\017 )0.5(\023\024\022\026\026\021\036\035\017 )0.5(\024\022\026\t\r\026\033\021\f\016 )0.6(\027\036\f\024\f\021\024\016\021\036\035\034\027\t\n\017. )]TJ 0.052 Tw T* (\211)Tj /Span<>> BDC ( )Tj EMC (\027\026\004\017\021\036\035\034\027\024\005 \004\026\f\021\017 \002\024\ \035\034\027\t\b \f)Tj /Span<>> BDC ( )Tj EMC (\023\024\030\026\032\036\027\017\036\n \021\024\027\022\024\005 )Tj 0.226 Tw T* [(\022\017\001\022\017 )0.5(\207\025 \023\030\024\021\036\022\026\036\021 \r)]TJ /Span<>> BDC ( )Tj EMC 10.171 0 Td [(\022\035\017\027\017\004\036\f\022\017 \f\021\036\030\021\024\005 )0.5(\235\024\030\n\036. )]TJ 0.201 Tw -10.171 -1.218 Td (\207\024\035\036\036 \021\024\020\024, \027\036\023\024\027\016\021\027\t\ \022\024\027\021\030\024\035\034\027\t\036 \021\024\004\022\017 \035\036\ \004\036\027\017\016 )Tj 0 Tw 0 -1.218 TD (\023\036\030\017\026\027\026\035\034\027\t\b \017)Tj /Span<>> BDC ( )Tj EMC (\r\027\036\022\017\001\036\004\027\t\b \023\030\024\016\r\035\036\027\017\ \005 [2].)Tj 0.341 Tw 0 -1.218 TD (\225-\030\036\026\022\021\017\r\027\t\005 \002\036\035\024\022 $\225\217\ \207$ \017)Tj /Span<>> BDC ( )Tj EMC (\235\036\022\026\035\034\027\t\005 \022\026\035\034\023\030\024)Tj 0 Tw (-)Tj 0.114 Tw 0 -1.218 TD (\021\036\022\021\017\027 $\205\025\215$ \016\r\035\016\033\021\f\016 \021\ \030\026\007\017\006\017\024\027\027\t\n\017 \021\036\f\021\026\n\017 \007\ \035\016 )Tj 0.155 Tw T* (\024\006\036\027\022\017 \220\235\235\036\022\021\017\r\027\024\f\021\017\ \021\036\030\026\023\017\017 \r\024 \r\030\036\n\016 \017\027\007\031\022\ \006\017\017 )Tj 0.128 Tw T* (\030\036\n\017\f\f\017\017 \017)Tj /Span<>> BDC ( )Tj EMC (\024\006\036\027\022\017 \036\201 \007\024\f\021\026\021\024\004\027\024\ \f\021\017 \r)Tj /Span<>> BDC ( )Tj EMC (\030\026\n\022\026\b \023\024\007)Tj 0 Tw (-)Tj 0.063 Tw T* [(\007\036\030\032\017\r\026\033\013\036\020\024 \022\031\030\f\026. R)12.9(einisch W. \017 \f\024\026\r\021. \023\024\022\026\026\035\017, )]TJ -0.01 Tw T* [(\004\021\024 )0.6(\027\024\030\n\026\035\017\026\006\017\016 )0.6(\225\217\207 )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC 10.219 0 Td [(\031\030\024\r\036\027\034 )0.6(\205\025\215 )0.6(\027\017\032\036 )0.6(250 )0.6(\n\022\020/\020 )]TJ 0.33 Tw -10.219 -1.218 Td (\027\026)Tj /Span<>> BDC ( )Tj EMC (14-\005 \027\036\007\036\035\036 \021\036\030\026\023\017\017 \016\r\035\ \016\036\021\f\016 \023\030\024\020\027\024\f\021\017\004\036\f\022\017 \ )Tj 0.11 Tw T* [(\002\035\026\020\024\023\030\017\016\021\027\t\n )0.6(\235\026\022\021\024\030\024\n )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 11.929 0 Td [(\024\021\027\024\001\036\027\017\017 )0.6(\031\f\023\036\b\026 )0.5(\021\036\030\026)]TJ 0 Tw (-)Tj 0.149 Tw -11.929 -1.218 Td (\023\017\017 \017\027\235\035\017\022\f\017\n\026\002\024\n [10]. Jahnse\ n J. \017 \f\024\026\r\021. \021\024\032\036 )Tj 0.06 Tw T* (\023\030\024\r\024\007\017\035\017 \022\024\027\021\030\024\035\034 \023\ \026\006\017\036\027\021\026\n \f)Tj /Span<>> BDC ( )Tj EMC (\207\025 \r)Tj /Span<>> BDC ( )Tj EMC (\024\002\255\036\n\036 \f\002\024\030\026 )Tj 0.115 Tw T* (\032\026\035\024\002, \026\027\026\035\017\026 \225\217\207 \017)Tj /Span<>> BDC ( )Tj EMC (\205\025\215 \027\026)Tj /Span<>> BDC ( )Tj EMC (14-\005 \027\036\007\036\035\036 \021\036\030\026\023\017\017. )Tj 0.156 Tw T* (\224\n\017 \002\t\035\026 \023\024\035\031\004\036\027\026 79% \220\235\235\ \036\022\021\017\r\027\024\f\021\034 \017\027\235\035\017\022\f\017)Tj 0 Tw (-)Tj T* (\n\026\002\026 [21].)Tj 0.21 Tw T* [(\202\022\021\017\r\027\024 \023\030\024\r\024\007\016\021\f\016 )0.5(\017\f\f\035\036\007\024\r\026\027\017\016 \023\024)]TJ /Span<>> BDC ( )Tj EMC (\021\036\030\026\023\036\r\021\017\004\036)Tj 0 Tw (-)Tj -0.027 Tw T* (\f\022\024\n\031 \035\036\022\026\030\f\021\r\036\027\027\024\n\031 \n\024\ \027\017\021\024\030\017\027\020\031 $\231\214\204$. \231\214\204 \206\ \224\207\215 )Tj 0.52 Tw T* (\002\t\r\026\036\021 \030\036\026\022\021\017\r\027\t\n \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\026\022\021\017\r\027\t\n. \217\036\026\022\021\017\r\027\t\ \005 )Tj 0.699 Tw T* (\231\214\204)Tj /Span<>> BDC ( )Tj EMC (\227 \n\024\027\017\021\024\030\017\027\020 \023\035\026\n\036\027\027\024\ \005 \022\024\027\006\036\027\021\030\026\006\017\017 )Tj 0.244 Tw T* (\206\224\207\215 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\027\036\007\024\f\021\017\032\036\027\017\017 \030\036\n\017\f\f\017\017\ \017\035\017 \023\024\021\036\030\036 \024\021)Tj 0 Tw (-)Tj 0.147 Tw T* (\r\036\021\026. \200)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\005 \f\017\021\031\026\006\017\017 \231\214\204 \023\024\r\ \024\035\016\036\021 \007\017\235\235\036\030\036\027\006\017)Tj 0 Tw (-)Tj 0.085 Tw T* (\030\024\r\026\021\034 \030\036\006\017\007\017\r \026\002\024\035\036\r\ \026\027\017\016, \f\r\016\026\027\027\t\005 \f\024 \f\027\017\032\036\027\ )Tj 0 Tw (-)Tj 0.378 Tw T* (\027\024\005 \022\024\027\006\036\027\021\030\026\006\017\036\005 \023\030\ \036\023\026\030\026\021\026 \024\021 \007\030\031\020\017\b \023\030\017\ \004\017\027. )Tj 0.067 Tw T* (\215\030\024\026\022\021\017\r\027\t\005 \231\214\204 \017\f\023\024\035\ \034\031\036\021\f\016 \007\035\016 \024\006\036\027\022\017 \006\036\035\ \036\r\t\b )Tj 0.088 Tw T* (\022\024\027\006\036\027\021\030\026\006\017\005 \023\030\036\023\026\030\ \026\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\006\036\035\034\033 \023\024\007\007\036\030\032\026\027\017\016 \030\036\ )Tj 0 Tw (-)Tj -0.013 Tw T* [(\n\017\f\f\017\017. )0.6(\200)]TJ /Span<>> BDC ( )Tj EMC 4.28 0 Td [(\030\036\021\030\024\f\023\036\022\021\017\r\027\024\n )0.6(\017\f\f\035\036\007\024\r\026\027\017\017 )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC 14.079 0 Td (\031\004\026\f\021\017\036\n )Tj 0.003 Tw -18.359 -1.218 Td (83 \023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\200\003\025 \027\026)Tj /Span<>> BDC ( )Tj EMC (10-\005 \027\036\007\036\035\036 \021\036\030\026\023\017\017 \023\024\022\ \026\026\027\024 )Tj 0.289 Tw T* (\024\021\f\031\021\f\021\r\017\036 \030\026\035\017\004\017\005 \n\036\032\ \007\031 \020\030\031\023\023\026\n\017 \f)Tj /Span<>> BDC ( )Tj EMC (\n\024\027\024\021\036\030\026)Tj 0 Tw (-)Tj 0.21 Tw T* (\023\017\036\005 \224\203\205 \023\024\007 \022\024\027\021\030\024\035\036\ \n \231\214\204 \f)Tj /Span<>> BDC ( )Tj EMC (\022\024\n\002\017\027\017\030\024\r\026\027\027\024\005 )Tj 0.234 Tw T* (\021\036\030\026\023\017\036\005 \002\036 \035\036\022\026\030\f\021\r\036\ \027\027\024\020\024 \n\024\027\017\021\024\030\017\027\020\026. \200\n\036\ \f\021\036 )Tj 0.394 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\021\036\n, \r\t\016\r\035\036\027\026 \027\026\004\017\n\026\016 \030\026\ \027\017\006\026 \n\036\032\007\031 \220\021\017\n\017 )Tj 0.264 Tw T* (\020\030\031\023\023\026\n\017 \017)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\024\005 \023\026\006\017\036\027\021\024\r, \023\024\ \035\031\004\026\r\001\017\b \n\024\027\024)Tj 0 Tw (-)Tj 0.054 Tw T* (\021\036\030\026\023\017\033 \224\203\205 \002\036 \035\036\022\026\030\ \f\021\r\036\027\027\024\020\024 \n\024\027\017\021\024\030\017\027\020\026\ [22]. )Tj 0.131 Tw T* (\200)Tj /Span<>> BDC ( )Tj EMC 0.909 0 Td [(\007\r\024\005\027\024\n )0.5(\f\035\036\023\024\n )0.5(\017\f\f\035\036\007\024\r\026\027\017\017 )0.5(\024\023\021\017\n\017\026\006\017\016 )0.6(\007\024\t )]TJ 0.025 Tw -0.909 -1.218 Td [(\224\203\205 )0.5(\023\030\024\r\024\007\017\035\026\f\034 )0.6(\r)]TJ /Span<>> BDC ( )Tj EMC 8.422 0 Td [(\020\030\031\023\023\026\b )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 4.215 0 Td [(\026\r\017\f\017\n\024\f\021\017 )0.6(\024\021 )0.5(\022\035\017\027\017)]TJ 0 Tw (-)Tj 0.095 Tw -12.637 -1.218 Td (\004\036\f\022\017\b \f\017\n\023\021\024\n\024\r, \023\024\022\026\026\ \021\036\035\036\005 \r\024\f\023\026\035\017\021\036\035\034\027\024\020\ \024 \024\021)Tj 0 Tw (-)Tj 0.123 Tw T* (\r\036\021\026 \017)Tj /Span<>> BDC ( )Tj EMC (\235\026\030\n\026\022\024\022\017\027\036\021\017\004\036\f\022\017\b \023\ \024\022\026\026\021\036\035\036\005. \200)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 )Tj 0.136 Tw T* (\022\024\027\021\030\024\035\016 \024\023\021\017\n\017\026\006\017\016\ \021\036\030\026\023\017\017 \023\030\024\017\f\b\024\007\017\035\026 \021\ \024\035\034\022\024 )Tj 0.123 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC (\024\f\027\024\r\026\027\017\017 \022\035\017\027\017\004\036\f\022\017\b\ \023\024\022\026\026\021\036\035\036\005. \200)Tj /Span<>> BDC ( )Tj EMC (\017\f\f\035\036\007\024)Tj 0 Tw (-)Tj -0.005 Tw T* (\r\026\027\017\017 \031\004\026\f\021\r\024\r\026\035\024 122 \023\026\006\ \017\036\027\021\026, \027\026\004\017\n\t\b \030\026\035\017\004\017\005\ )Tj 0 Tw T* (\027\036 \023\024\035\031\004\036\027\024 [23].)Tj -0.007 Tw T* (\200 \017\f\f\035\036\007\024\r\026\027\017\017 \f)Tj /Span<>> BDC ( )Tj EMC (\031\004\026\f\021\017\036\n 110 \023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\207\025 \f\t\r\024)Tj 0 Tw (-)Tj 0.074 Tw T* (\030\024\021\024\004\027\t\036 \022\024\027\006\036\027\021\030\026\006\017\ \017 \224\203\205 \002\024\035\036\036 2,2 \n\022\020/\n\035 \002\t\035\017\ )Tj 0.299 Tw 23.244 64.543 Td (\026\f\f\024\006\017\017\030\024\r\026\027\t \f)Tj /Span<>> BDC ( )Tj EMC (\002\017\024\b\017\n\017\004\036\f\022\024\005 \030\036\n\017\f\f\017\036\ \005 $\027\024\030)Tj 0 Tw (-)Tj 0.267 Tw T* (\n\026\035\034\027\t\036 \027\026\004\036\027\017\016 \225\217\207$, \031\ \030\024\r\036\027\034 \r\t\001\036 9,7)Tj /Span<>> BDC ( )Tj EMC (\n\022\020/\n\035 )Tj 0.318 Tw T* (\026\f\f\024\006\017\017\030\024\r\026\027 \f)Tj /Span<>> BDC ( )Tj EMC (\220\027\007\024\f\022\024\023\017\004\036\f\022\024\005 \030\036\n\017\f\ \f\017\036\005, \031\030\024)Tj 0 Tw (-)Tj 0.06 Tw T* (\r\036\027\034 \r\t\001\036 9,8 \n\022\020/\n\035 \026\f\f\024\006\017\017\ \030\024\r\026\027 \f)Tj /Span<>> BDC ( )Tj EMC (\n\024\030\235\024\035\024\020\017\004\036)Tj 0 Tw (-)Tj 0.144 Tw T* [(\f\022\024\005 )0.5(\030\036\n\017\f\f\017\036\005 )0.6(\027\026)]TJ /Span<>> BDC ( )Tj EMC 8.454 0 Td [(\235\024\027\036 )0.5(\023\024\007\007\036\030\032\017\r\026\033\013\036\005 )0.6(\021\036\030\026\023\017\017 )]TJ 0.193 Tw -8.454 -1.218 Td [(\017\027\235\035\017\022\f\017\n\026\002\024\n )0.6([24]. )0.5(\025\030\024\n\036 )0.5(\021\024\020\024, )0.5(\031\f\021\026\027\024\r\035\036\027\024, )0.6(\004\021\024 )]TJ 0.29 Tw 0 -1.218 TD (\024\023\021\017\n\017\026\006\017\016 \021\036\030\026\023\017\017 \r)Tj /Span<>> BDC ( )Tj EMC (\030\026\n\022\026\b \023\030\024\026\022\021\017\r\027\024\020\024 \231\ \214\204 )Tj 0.359 Tw 0 -1.218 TD (\023\030\017\r\024\007\017\035\026 \022)Tj /Span<>> BDC ( )Tj EMC (\f\031\013\036\f\021\r\036\027\027\024\n\031 \f\027\017\032\036\027\017\033\ \023\024\021\030\036\002\027\024)Tj 0 Tw (-)Tj 0.05 Tw T* (\f\021\017 \r)Tj /Span<>> BDC ( )Tj EMC (\b\017\030\031\030\020\017\004\036\f\022\024\n \035\036\004\036\027\017\017\ , \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\n \231\214\204 \024\002\035\026\007\026\035 )Tj -0.011 Tw T* (\002\024\035\034\001\036\005 \027\026\004\017\n\024\f\021\034\033 \r)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\n \r\024\023\030\024\f\036, \004\036\n \007\017\027\026\n\017\ \004\036)Tj 0 Tw (-)Tj 0.162 Tw T* (\f\022\017\005 \022\024\027\021\030\024\035\034 \205\025\215 [25,26]. \200\ \t\032\017\r\026\036\n\024\f\021\034 \021\036\030\026\023\017\017 )Tj 0.14 Tw T* (\224\203\205 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\r\036\007\036\027\017\017 \n\024\027\017\021\024\030\017\027\ \020\026 \021\026\022\032\036 \024\022\026\026\035\026\f\034 )Tj 0.156 Tw 0 -1.218 TD (\r\t\001\036 [27,28]. \210\007\027\026\022\024 \021\030\036\002\031\036\021\ \f\016 \002\024\035\034\001\036 \017\f\f\035\036\007\024\r\026)Tj 0 Tw (-)Tj 0.014 Tw 0 -1.218 TD [(\027\017\005 )0.5(\007\035\016 \r\026\035\017\007\026\006\017\017 \f\030\024\022\024\r \017\ )]TJ /Span<>> BDC ( )Tj EMC 12.046 0 Td (\r\017\007\024\r \021\036\030\026\023\036\r\021\017\004\036\f\022\024\020\ \024 )Tj 0 Tw -12.046 -1.218 Td (\035\036\022\026\030\f\021\r\036\027\027\024\020\024 \n\024\027\017\021\024\ \030\017\027\020\026 [29].)Tj 0.047 Tw 0 -1.218 TD (\224 \n\036\021\024\007\024\r \r\017\031\026\035\017\026\006\017\017 \ \r)Tj /Span<>> BDC ( )Tj EMC (\030\026\n\022\026\b \022\024\027\021\030\024\035\016 \220\235\235\036\022\ )Tj 0 Tw (-)Tj 0.03 Tw T* (\021\017\r\027\024\f\021\017 \021\036\030\026\023\017\017 \r)Tj /Span<>> BDC ( )Tj EMC (\022\024\030\024\021\022\017\036 \f\030\024\022\017 \023\024\f\035\036 \027\ \026\004\026\035\026 \035\036)Tj 0 Tw (-)Tj 0.241 Tw T* (\004\036\027\017\016 \024\f\024\002\024\036 \n\036\f\021\024 \026\027\017\ \n\026\036\021 \021\030\026\027\f\026\002\007\024\n\017\027\026\035\034\027\ \024\036 )Tj 0.1 Tw T* (\211\003\224 \022\017\001\036\004\027\017\022\026, \022\024\021\024\030\024\ \036 \023\024\r\024\035\016\036\021 \024\006\036\027\017\021\034 \017\n\ \036\027\036)Tj 0 Tw (-)Tj 0.188 Tw T* [(\027\017\036 )0.5(\021\024\035\013\017\027\t )0.6(\022\017\001\036\004\027\024\005 )0.5(\f\021\036\027\022\017 )0.6(\r\024\f\023\026\035\036\027\027\t\b )0.5(\031\004\026\f\021)]TJ 0 Tw (-)Tj 0.253 Tw T* (\022\024\r \017, \036\f\035\017 \017\f\023\024\035\034\024\r\026\021\034\ \n\036\021\024\007\017\022\031 \f)Tj /Span<>> BDC ( )Tj EMC (\022\024\027\021\030\026\f\021\027\t\n )Tj 0.144 Tw T* (\031\f\017\035\036\027\017\036\n, \n\024\032\027\024 \024\006\036\027\017\ \021\034 \017\n\036\027\036\027\017\036 \r\026\f\022\031\035\016\030\017\ \026)Tj 0 Tw (-)Tj 0.079 Tw T* (\006\017\017 \r\024\f\023\026\035\036\027\027\024\020\024 \f\036\020\n\036\ \027\021\026. \200)Tj /Span<>> BDC ( )Tj EMC (\017\f\f\035\036\007\024\r\026\027\017\017 2020)Tj /Span<>> BDC ( )Tj EMC (\020. )Tj 0.216 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\031\004\026\f\021\017\036\n 54 \023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\207\025 \002\t\035\024 \023\024\022\026\026\027\024, \004\021\024 )Tj -0.015 Tw T* (\031\n\036\027\034\001\036\027\017\036 \021\024\035\013\017\027\t \022\017\ \001\036\004\027\024\005 \f\021\036\027\022\017 \f)Tj /Span<>> BDC ( )Tj EMC (4 \023\024)Tj /Span<>> BDC ( )Tj EMC (8)Tj /Span<>> BDC ( )Tj EMC (\027\036\007\036)Tj 0 Tw (-)Tj 0.015 Tw T* (\035\033 \021\036\030\026\023\017\017 \016\r\035\016\036\021\f\016 \023\030\ \036\007\017\022\021\024\030\024\n \220\027\007\024\f\022\024\023\017\004\ \036\f\022\024\020\024 )Tj 0.096 Tw T* [(\024\021\r\036\021\026 )0.5(\004\036\030\036 )0.6(12\22624)]TJ /Span<>> BDC ( )Tj EMC 8.538 0 Td [(\n\036\f\016\006\026, )0.5(\023\030\017)]TJ /Span<>> BDC ( )Tj EMC 5.281 0 Td [(\220\021\024\n )0.5(\024\021\f\031\021\f\021\r\017\036 )0.6(\030\036)]TJ 0 Tw (-)Tj 0.198 Tw -13.819 -1.218 Td (\007\031\022\006\017\017 \027\026)Tj /Span<>> BDC ( )Tj EMC 4.78 0 Td [(6-\005 \027\036\007\036\035\036 )0.5(\f\r\017\007\036\021\036\035\034\f\021\r\024\r\026\035\024 )0.5(\024\002 \024\021\f\031\021)]TJ 0 Tw (-)Tj -4.78 -1.218 Td (\f\021\r\017\017 \024\021\r\036\021\026 \027\026)Tj /Span<>> BDC ( )Tj EMC (\021\036\030\026\023\017\033 [30].)Tj /T1_1 1 Tf 0 -2.436 TD (\026\004\006\t\004\b\003\013 \002\212\003\t\214\t\213\004\204\t\t \003\r\ \006\004\212\t\t)Tj /T1_0 1 Tf 0.011 Tw 0 -1.218 TD (\215\030\017\027\017\n\026\016 \r\024 \r\027\017\n\026\027\017\036 \f\030\ \026\r\027\017\021\036\035\034\027\024 \027\036\r\t\f\024\022\031\033 \220\ \235)Tj 0 Tw (-)Tj 0.132 Tw T* (\235\036\022\021\017\r\027\024\f\021\034 \021\036\030\026\023\017\017 \206\ \224\207\215 \r)Tj /Span<>> BDC ( )Tj EMC (\f\021\026\027\007\026\030\021\027\t\b \030\036\032\017\n\026\b, )Tj 0.096 Tw T* (\024\f\021\030\024 \r\f\021\026\036\021 \r\024\023\030\024\f \024)Tj /Span<>> BDC ( )Tj EMC (\r\026\030\017\026\027\021\026\b \024\023\021\017\n\017\026\006\017\017\ \021\036\030\026)Tj 0 Tw (-)Tj 0.192 Tw T* (\023\017\017. \200)Tj /Span<>> BDC ( )Tj EMC 3.228 0 Td [(\026\r\017\f\017\n\024\f\021\017 )0.5(\024\021 \022\035\017\027\017\004\036\f\022\024\005 \f\017\021\031\026\006\ \017\017, )0.5(\r\024)]TJ 0 Tw (-)Tj 0.083 Tw -3.228 -1.218 Td (\n\024\032\027\024 \031\r\036\035\017\004\036\027\017\036 \007\024\t \023\ \030\036\023\026\030\026\021\026, \017\035\017 \f\024\022\030\026\013\036\ \027\017\036 )Tj 0.131 Tw T* (\017\027\021\036\030\r\026\035\024\r \n\036\032\007\031 \r\r\036\007\036\ \027\017\016\n\017, \017\035\017 \022\024\n\002\017\027\026\006\017\016 \ \021\036)Tj 0 Tw (-)Tj T* (\030\026\023\017\017 \224\203\205 \f)Tj /Span<>> BDC ( )Tj EMC (\026\026\021\017\024\023\030\017\027\024\n.)Tj 0.003 Tw T* (\225 \006\036\035\034\033 \023\024\r\t\001\036\027\017\016 \r\036\030\024\ \016\021\027\024\f\021\017 \027\026\f\021\031\023\035\036\027\017\016 \030\ \036\n\017\f)Tj 0 Tw (-)Tj 0.162 Tw T* [(\f\017\017 )0.5(\031)]TJ /Span<>> BDC ( )Tj EMC 2.707 0 Td [(\023\026\006\017\036\027\021\024\r )0.6(\f)]TJ /Span<>> BDC ( )Tj EMC 5.548 0 Td [(\207\025, )0.5(\024\032\017\030\036\027\017\036\n, )0.6(\027\017\022\017\n )0.5(\031\030\024\r\027\036\n )]TJ 0.045 Tw -8.255 -1.218 Td (\026\035\034\002\031\n\017\027\026 \017)Tj /Span<>> BDC ( )Tj EMC [(\r\t\f\024\022\017\n \031\030\024\r\027\036\n \225\217\207, R)13(einisch)]TJ /Span<>> BDC ( )Tj EMC (W. \017)Tj /Span<>> BDC ( )Tj EMC (\f\024)Tj 0 Tw (-)Tj 0.255 Tw T* [(\026\r\021. )0.5(\030\036\022\024\n\036\027\007\031\033\021 )0.6(\023\030\024\r\024\007\017\021\034 )0.5(\017\027\007\031\022\006\017\033 )0.6(\224\203\205 )0.6(\f\030\026\031 )]TJ 0.017 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\007\024\036 10 \n\020/\022\020. \231\026\022\026\016 \030\036\022\024\n\ \036\027\007\026\006\017\016 \r\023\024\035\027\036 \024\002\024\f\027\024\ )Tj 0 Tw (-)Tj 0.112 Tw T* (\r\026\027\026 \f)Tj /Span<>> BDC ( )Tj EMC (\021\024\004\022\017 \030\036\027\017\016 \235\026\030\n\026\022\024\022\ \017\027\036\021\017\004\036\f\022\017\b \b\026\030\026\022\021\036)Tj 0 Tw (-)Tj 0.051 Tw T* (\030\017\f\021\017\022, \021\026\022 \022\026\022 \r)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\024\n \f\035\031\004\026\036 \007\024\f\021\017\020\026\036\ \021\f\016 \027\026\017\002\024\035\036\036 )Tj 0 Tw T* (\r\t\f\024\022\026\016 \023\035\026\n\036\027\027\026\016 \022\024\027\006\ \036\027\021\030\026\006\017\016 \023\030\036\023\026\030\026\021\026 [1\ 0].)Tj 0.147 Tw T* (\215\024 \007\026\027\027\t\n \026\027\026\035\017\026 \022\026\027\026\ \007\f\022\024\020\024 \030\036\020\017\f\021\030\026 \023\026\006\017\036\ \027\021\024\r )Tj 0.089 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\200\003\025 \r\t\016\r\035\036\027\024, \004\021\024 \022\024\n\002\017\ \027\017\030\024\r\026\027\027\026\016 \021\036\030\026\023\017\016 \224\ \203\205 )Tj 0.067 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\026\026\021\017\024\023\030\017\027\024\n \027\026\004\017\n\024 \031\ \r\036\035\017\004\017\r\026\035\026 \022\026\022 \027\036\023\024\f\030\ \036\007)Tj 0 Tw (-)Tj 0.293 Tw T* (\f\021\r\036\027\027\031\033 \220\235\235\036\022\021\017\r\027\024\f\021\ \034, \021\026\022 \017)Tj /Span<>> BDC ( )Tj EMC (\036\201 \r\t\032\017\r\026\036\n\024\f\021\034. )Tj 0.004 Tw T* (\025\030\024\n\036 \021\024\020\024, \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\r\036\007\036\027\017\017 \n\027\024\020\024\004\017\f\035\036\ \027\027\t\b \235\026\030\n\026)Tj 0 Tw (-)Tj -0.001 Tw T* [(\022\024\022\017\027\036\021\017\004\036\f\022\017\b )0.6(\017\f\f\035\036\007\024\r\026\027\017\005 )0.5(\024\002\027\026\030\031\032\036\027\024 )0.6(\027\026\004\017\n\024\036 )]TJ 0 Tw T* (\f\027\017\032\036\027\017\036 \027\036\005\021\030\026\035\017\031\033\ \013\017\b \026\027\021\017\035\036\022\026\030\f\021\r\036\027\027\t\b \ \026\027\021\017)Tj (-)Tj 0.364 Tw T* (\021\036\035 \017, \f\024\024\021\r\036\021\f\021\r\036\027\027\024, \031\ \035\031\004\001\036\027\017\036 \002\017\024\007\024\f\021\031\023\027\024\ \f\021\017 )Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0 Tw 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\205)10(\210\036\033 \035\030\032\204\033)30(\021)42(\032)-21(\211\033\237)]TJ 57.136 0 Td (REVIEW)Tj -57.136 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 23, \023\0222, 202)69(4)]TJ 42.99 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 23, \023\0222, 202)69(4)]TJ /T1_3 1 Tf 25 0 0 25 20.84 56.0378 Tm (176)Tj ET endstream endobj 73 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 74 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 75 0 obj <>/ExtGState<>/Font<>/ProcSet[/PDF/Text]/Properties<>/Shading<>/XObject<>>>/TrimBox[0.0 0.0 566.929 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0 0 0 1 k /GS1 gs /T1_1 1 Tf 10 0 0 10 42.5197 724.8299 Tm (\203\004\220\003\002\006\013, \f\t\235\211\232\t\r \b\004)Tj /Span<>> BDC ( )Tj EMC (\236\226\226\r\220\003\t\b\002\217\003\001 \003\r\006\004\212\t\t.)Tj /T1_2 1 Tf 0.052 Tw 0 -1.218 TD (\200 \027\026\f\021\024\016\013\036\036 \r\030\036\n\016 \n\t \027\026\002\ \035\033\007\026\036\n \021\036\027\007\036\027\006\017\033 \026\022\021\ \017\r)Tj 0 Tw (-)Tj 0.069 Tw T* (\027\024\020\024 \023\024\017\f\022\026 \022\026\022 \022\035\017\027\017\ \004\036\f\022\017\b, \007\024\f\021\031\023\027\t\b \r)Tj /Span<>> BDC ( )Tj EMC (\030\031\021\017\027\027\024\005 )Tj 0.272 Tw T* (\023\030\026\022\021\017\022\036, \021\026\022 \017)Tj /Span<>> BDC ( )Tj EMC (\035\026\002\024\030\026\021\024\030\027\t\b \023\030\036\007\017\022\021\ \024\030\024\r \024\021\r\036\021\026 )Tj -0.026 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC (\021\036\030\026\023\017\033 \017)Tj /Span<>> BDC ( )Tj EMC (\036\201 \r\t\032\017\r\026\036\n\024\f\021\034 \f)Tj /Span<>> BDC ( )Tj EMC (\006\036\035\034\033 \024\023\021\017\n\026\035\034\027\024\020\024 )Tj 0 Tw T* (\r\t\002\024\030\026 \f\b\036\n\t \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\036\023\026\030\026\021\026 \007\035\016 \035\036\004\036\027\017\ \016 \200\003\025.)Tj 0.083 Tw 0 -1.218 TD (\225\030\036\007\017 \024\002\013\036\022\035\017\027\017\004\036\f\022\017\ \b \023\026\030\026\n\036\021\030\024\r, \r\024\n\024\032\027\024 \r\035\ \017)Tj 0 Tw (-)Tj 0.092 Tw 0 -1.218 TD (\016\033\013\017\b \027\026)Tj /Span<>> BDC ( )Tj EMC [(\220\235\235\036\022\021\017\r\027\024\f\021\034 )0.5(\021\036\030\026\023\017\017, \030\026\f\f\n\026\021\030\017\r\026\033\021\ \f\016 )]TJ 0.168 Tw T* (\021\017\023 \200\003\025, \026)Tj /Span<>> BDC ( )Tj EMC (\007\035\016 \207\025 \036\013\201 \017)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\017\036 \023\026\030\026\n\036\021\030\t, \022\026\022 \235\ \036)Tj 0 Tw (-)Tj 0.289 Tw T* [(\027\024\021\017\023 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 3.971 0 Td [(\023\030\024\021\016\032\036\027\027\024\f\021\034 )0.6(\023\024\030\026\032\036\027\017\016; )0.6(\017\027\007\036\022\f )0.5(\n\026\f\f\t )]TJ 0.445 Tw -3.971 -1.218 Td [(\021\036\035\026 $\224\204\231$, \031\030\024\r\036\027\034 \r\024\f\023\ \026\035\017\021\036\035\034\027\024\005 )0.5(\026\022\021\017\r\027\024\f\021\017. )]TJ 0.04 Tw T* (\215\024\022\026\026\027\024, \004\021\024 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\242\025 \035\036\004\036\027\017\036 \224\203\205 \002\024\035\036\036 \ \220\235\235\036\022\021\017\r)Tj 0 Tw (-)Tj 0.043 Tw 0 -1.218 TD (\027\024, \004\036\n \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\207\025. \215\030\017)Tj /Span<>> BDC ( )Tj EMC [(\220\021\024\n \f\021\024\017\021 \024\021\n\036\021\017\021\034, )0.5(\004\021\024 \004\026\f\021\024\021\026 )]TJ 0.034 Tw 0 -1.218 TD (\030\036\n\017\f\f\017\005 \017)Tj /Span<>> BDC ( )Tj EMC (\022\035\017\027\017\004\036\f\022\024\020\024 \024\021\r\036\021\026 \023\ \030\017)Tj /Span<>> BDC ( )Tj EMC (\242\025 \002\024\035\034\001\036, \004\036\n )Tj -0.038 Tw 0 -1.218 TD (\023\030\017)Tj /Span<>> BDC ( )Tj EMC (\207\025 \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\017 \026\027\026\035\017\036 \007\030\031\020\017\b \206\224\207\ \215 \017)Tj /Span<>> BDC ( )Tj EMC (\231\224\225. \215\030\017)Tj /Span<>> BDC ( )Tj EMC (\207\025 \224\203\205 )Tj 0.388 Tw T* (\002\024\035\036\036 \220\235\235\036\022\021\017\r\036\027 \f\030\026\r\ \027\017\021\036\035\034\027\024 \f)Tj /Span<>> BDC ( )Tj EMC (\026\007\026\035\017\n\031\n\026\002\024\n )Tj 0.011 Tw T* ($\202\212\202$ \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\017\024\035\017\030\024\r\026\027\027\024\n \023\024\030\026\032\036\027\ \017\017 \021\024\035\f\021\024\005 \022\017\001\022\017 )Tj 0.167 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\023\030\017 \027\026\035\017\004\017\017 \023\036\030\017\026\027\026\035\ \034\027\t\b \023\030\024\016\r\035\036\027\017\005 $\215\215$. \203\024\ )Tj 0.144 Tw T* (\023\030\017)Tj /Span<>> BDC ( )Tj EMC 1.897 0 Td [(\220\021\024\n )0.5(\202\212\202 )0.6(\f\030\026\r\027\017\021\036\035\034\027\024 )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC 11.22 0 Td [(\224\203\205 )0.5(\002\024\035\036\036 )0.5(\220\235\235\036\022\021\017)]TJ 0 Tw (-)Tj 0.09 Tw -13.117 -1.218 Td (\r\036\027 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\f\021\030\017\022\021\031\030\017\030\031\033\013\036\n \235\036\027\024\ \021\017\023\036 \207\025. \224\203\205 \021\026\022\032\036 )Tj 0.182 Tw T* (\023\024\022\026\026\035 \f\r\024\033 \002\024\035\034\001\031\033 \220\ \235\235\036\022\021\017\r\027\024\f\021\034 \f\030\026\r\027\017\021\036\ \035\034)Tj 0 Tw (-)Tj 0.085 Tw T* (\027\024 \f)Tj /Span<>> BDC ( )Tj EMC (\202\212\202 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\n\026\f\f\036 \021\036\035\026 \023\026\006\017\036\027\021\026 \002\024\ \035\036\036 80 \022\020 [10]. )Tj 0.058 Tw T* (\203\026)Tj /Span<>> BDC ( )Tj EMC (\027\026\001 \r\020\035\016\007, \220\021\024 \030\026\035\017\004\017\ \036 \f\r\016\026\027\024 \f)Tj /Span<>> BDC ( )Tj EMC (\024\f\024\002\036\027\027\024\f\021\016)Tj 0 Tw (-)Tj -0.022 Tw T* (\n\017 \007\024\017\030\024\r\026\027\017\016 \023\030\036\023\026\030\026\ \021\024\r. \213\f\035\017 \007\024\026 \202\212\202 \027\036\017\n\036\ \027)Tj 0 Tw (-)Tj 0.096 Tw T* [(\027\026 )0.6(\027\036\026\r\017\f\017\n\024 )0.6(\024\021 )0.6(\n\026\f\f\t )0.5(\021\036\035\026, )0.6(\021\024 )0.6(\007\035\016 )0.6(\224\203\205 )0.5(\021\030\036\002\031\036\021\f\016 )]TJ 0.001 Tw T* (\023\036\030\036\f\004\036\021 \023\024)Tj /Span<>> BDC ( )Tj EMC (\n\026\f\f\036 \021\036\035\026. \200)Tj /Span<>> BDC ( )Tj EMC (\f\r\016\017 \f)Tj /Span<>> BDC ( )Tj EMC (\220\021\017\n \022\026\032\036\021\f\016 \r\036\030\024)Tj 0 Tw (-)Tj 0.065 Tw T* (\016\021\027\t\n, \004\021\024 \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\r\t\f\024\022\024\005 \n\026\f\f\024\005 \021\036\035\026 \023\035\026\ )Tj 0 Tw (-)Tj T* (\n\036\027\027\026\016 \022\024\027\006\036\027\021\030\026\006\017\016 \ \023\030\036\023\026\030\026\021\026 \002\031\007\036\021 \r\t\001\036.)Tj 0.086 Tw T* [(\213\013\201 \024\007\027\017\n \n\024\n\036\027\021\024\n, \r\035\017\016\ \033\013\017\n )0.5(\027\026)]TJ /Span<>> BDC ( )Tj EMC [(\023\030\024\020\027\024 )0.5(\220\235\235\036\022)]TJ 0 Tw (-)Tj 0.159 Tw T* (\021\017\r\027\024\f\021\017 \021\036\030\026\023\017\017 \224\203\205, \ \016\r\035\016\036\021\f\016 \036\020\024 \030\026\027\027\036\036 \027\026\ \027\026)Tj 0 Tw (-)Tj 0.054 Tw T* (\004\036\027\017\036 \r)Tj /Span<>> BDC ( )Tj EMC (\022\024\n\002\017\027\026\006\017\017 \f)Tj /Span<>> BDC ( )Tj EMC (\017\n\n\031\027\024\f\031\023\030\036\f\f\024\030\026\n\017. \200)Tj /Span<>> BDC ( )Tj EMC (\n\036\021\026)Tj 0 Tw (-)Tj 0.01 Tw T* (\026\027\026\035\017\036, \024\023\031\002\035\017\022\024\r\026\027\027\ \024\n \r)Tj /Span<>> BDC ( )Tj EMC (2018 \020. \017)Tj /Span<>> BDC ( )Tj EMC (\r\022\035\033\004\017\r\001\017\n 19 )Tj 0.044 Tw T* [(\017\f\f\035\036\007\024\r\026\027\017\005, )0.5(\023\024\022\026\026\027\024, \004\021\024 \022\024\n\002\017\027\017\030\ \024\r\026\027\027\026\016 )0.5(\021\036\030\026)]TJ 0 Tw (-)Tj 0.102 Tw T* (\023\017\016 \224\203\205 \f)Tj /Span<>> BDC ( )Tj EMC (\017\n\n\031\027\024\f\031\023\030\036\f\f\024\030\024\n \016\r\035\016\036\ \021\f\016 \023\030\024\020\027\024\f\021\017)Tj 0 Tw (-)Tj 0.001 Tw T* [(\004\036\f\022\017 \002\024\035\036\036 )0.5(\002\035\026\020\024\023\030\017\016\021\027\024\005, )0.5(\004\036\n \027\026\027\026\004\036\027\017\036 )0.6(\224\203\205 \023\024)]TJ 0 Tw (-)Tj 0.199 Tw T* (\f\035\036 \021\036\030\026\023\017\017 \017\n\n\031\027\024\f\031\023\030\ \036\f\f\024\030\026\n\017 $step-up \023\024\007\b\024\007$ )Tj 0.096 Tw T* (\017\035\017 \007\024\002\026\r\035\036\027\017\036 \017\b \022)Tj /Span<>> BDC ( )Tj EMC (\031\032\036 \023\024\035\031\004\026\036\n\024\005 \021\036\030\026\023\ \017\017 \224\203\205. )Tj 0.134 Tw T* (\225\024\024\021\r\036\021\f\021\r\036\027\027\024, \023\026\006\017\036\ \027\021\t, \022\024\021\024\030\t\n \023\024)Tj /Span<>> BDC ( )Tj EMC (\030\026\027\t\n \023\030\017)Tj 0 Tw (-)Tj 0.129 Tw T* [(\004\017\027\026\n )0.5(\017\n\n\031\027\024\f\031\023\030\036\f\f\024\030\t )0.6(\027\026\027\026\004\036\027\t )0.6(\002\t\021\034 )0.5(\027\036 )0.5(\n\024\020\031\021, )]TJ 0 Tw T* (\002\031\007\031\021 \b\031\032\036 \024\021\r\036\004\026\021\034 \027\026\ )Tj /Span<>> BDC ( )Tj EMC (\035\036\004\036\027\017\036 [11].)Tj -0.001 Tw T* (\224 \235\026\022\021\024\030\024\r, \022\024\021\024\030\t\036 \023\024\ \022\026 \027\036 \r\024\001\035\017 \r)Tj /Span<>> BDC ( )Tj EMC (\023\024\r\f\036\n\036\f\021\027\031\033 )Tj 0.137 Tw T* (\030\031\021\017\027\027\031\033 \022\035\017\027\017\004\036\f\022\031\033\ \023\030\026\022\021\017\022\031, \027\036\n\026\035\024\036 \027\026\004\ \036\027\017\036 )Tj -0.064 Tw T* (\017\n\036\033\021 \235\026\030\n\026\022\024\022\017\027\036\021\017\004\ \036\f\022\017\036 \023\024\022\026\026\021\036\035\017. \025)Tj /Span<>> BDC ( )Tj EMC (\027\017\n \024\021\027\024)Tj 0 Tw (-)Tj 0.003 Tw T* (\f\016\021\f\016 \023\035\026\n\036\027\027\026\016 \022\024\027\006\036\ \027\021\030\026\006\017\016 \023\030\036\023\026\030\026\021\026 \017)Tj /Span<>> BDC ( )Tj EMC (\022\024\027\006\036\027)Tj 0 Tw (-)Tj 0.035 Tw T* (\021\030\026\006\017\016 \027\036\005\021\030\026\035\017\031\033\013\017\ \b \026\027\021\017\021\036\035. \225\021\024\017\021 \024\021\n\036\021\ \017\021\034, \004\021\024 )Tj -0.023 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\r\f\036\005 \035\017\027\036\005\022\017 \017\n\036\033\013\017\b\f\016\ \r)Tj /Span<>> BDC ( )Tj EMC (\027\026\f\021\024\016\013\036\036 \r\030\036\n\016 \206\224\207\215 )Tj -0.033 Tw T* (\007\035\016 \035\036\004\036\027\017\016 \200\003\025, \224\203\205 \016\ \r\035\016\036\021\f\016 \f\026\n\t\n \017\n\n\031\027\024\020\036\027\027\ \t\n )Tj 0.186 Tw T* ([12]. \200\t\f\024\022\026\016 \023\035\026\n\036\027\027\026\016 \022\024\ \027\006\036\027\021\030\026\006\017\016 \023\030\036\023\026\030\026\021\ \026 )Tj 0.054 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\030\026\027\t\036 \f\030\024\022\017 \021\036\030\026\023\017\017 \016\ \r\035\016\036\021\f\016 \235\026\022\021\024\030\024\n, \024\023\030\036\ \007\036)Tj 0 Tw (-)Tj 0.14 Tw T* (\035\016\033\013\017\n \220\235\235\036\022\021\017\r\027\024\f\021\034 \ \021\036\030\026\023\017\017, \r)Tj /Span<>> BDC ( )Tj EMC (\021\024\n \004\017\f\035\036 \026\002\007\024)Tj 0 Tw (-)Tj 0.069 Tw T* (\n\017\027\026\035\034\027\024\005 \023\036\027\036\021\030\017\030\031\033\ \013\036\005 \235\024\030\n\t \207\025 \017)Tj /Span<>> BDC ( )Tj EMC (\026\032\017\r\035\036\027\017\036 )Tj 0.025 Tw T* (\023\036\030\017\026\027\026\035\034\027\t\b \023\030\024\016\r\035\036\027\ \017\005. \025\030\024\n\036 \021\024\020\024, \r\024\n\024\032\027\024\ \f\021\034 )Tj -0.043 Tw T* (\024\006\036\027\022\017 \023\035\026\n\036\027\027\024\005 \022\024\027\ \006\036\027\021\030\026\006\017\017 \224\203\205 \024\021\022\030\t\r\026\ \036\021 \r\026)Tj 0 Tw (-)Tj 0.118 Tw T* [(\030\017\026\027\021\t )0.5(\023\036\030\f\024\027\026\035\017\017\030\024\r\026\027\027\024\005 )0.5(\024\023\021\017\n\017\026\006\017\017 )0.6(\021\036\030\026\023\017\017 )]TJ 0.102 Tw 23.244 64.543 Td [([13\22615]. )0.5(\025)]TJ /Span<>> BDC ( )Tj EMC 4.82 0 Td [(\f\024\032\026\035\036\027\017\033, )0.6(\r)]TJ /Span<>> BDC ( )Tj EMC 6.032 0 Td [(\027\026\f\021\024\016\013\036\036 )0.6(\r\030\036\n\016 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 8.337 0 Td (\217\024\f\f\017\017 )Tj 0.317 Tw -19.189 -1.218 Td (\n\026\035\024\007\024\f\021\031\023\027\t \035\026\002\024\030\026\021\024\ \030\027\t\036 \021\036\f\021\t, \024\023\030\036\007\036\035\016\033\013\ \017\036 )Tj 0.044 Tw T* (\235\026\030\n\026\022\024\022\017\027\036\021\017\004\036\f\022\017\036\ \023\024\022\026\026\021\036\035\017 \206\224\207\215. \025\030\024\n\036\ \021\024\020\024, )Tj 0.019 Tw T* [(\027\036 )0.5(\030\036\020\035\026\n\036\027\021\017\030\024\r\026\027\t )0.6(\f\030\024\022\017 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 12.71 0 Td [(\007\017\026\023\026\024\027\t )0.6(\022\024\027\006\036\027\021\030\026)]TJ 0 Tw (-)Tj -0.042 Tw -12.71 -1.218 Td (\006\017\005, \016\r\035\016\033\013\017\036\f\016 \027\026\017\002\024\035\ \036\036 \023\030\024\020\027\024\f\021\017\004\036\f\022\017 \006\036\027\ \027\t\n\017.)Tj 0.339 Tw T* (\202\022\021\017\r\027\024 \024\002\f\031\032\007\026\036\021\f\016 \027\ \026\004\017\n\024\f\021\034 \027\036\005\021\030\026\035\017\031\033\013\ \017\b )Tj 0.076 Tw 0 -1.218 TD (\026\027\021\017\035\036\022\026\030\f\021\r\036\027\027\t\b \026\027\021\ \017\021\036\035 \r)Tj /Span<>> BDC ( )Tj EMC (\022\026\004\036\f\021\r\036 \023\030\024\020\027\024\f\021\017\004\036)Tj 0 Tw (-)Tj 0.023 Tw 0 -1.218 TD (\f\022\024\020\024 \n\026\030\022\036\030\026 \220\235\235\036\022\021\017\ \r\027\024\f\021\017 \021\036\030\026\023\017\017. \210\007\027\026\022\024\ , \036\f\035\017 )Tj 0.436 Tw T* (\023\024)Tj /Span<>> BDC ( )Tj EMC (\r\024\023\030\024\f\031 \023\035\026\n\036\027\027\t\b \022\024\027\006\ \036\027\021\030\026\006\017\005 \023\030\036\023\026\030\026\021\026 )Tj 0.228 Tw T* (\n\027\036\027\017\016 \f\023\036\006\017\026\035\017\f\021\024\r \030\026\ \f\b\024\007\016\021\f\016 \021\024\035\034\022\024 \r)Tj /Span<>> BDC ( )Tj EMC (\017\b \022\024\027)Tj 0 Tw (-)Tj 0.059 Tw T* (\022\030\036\021\027\t\b \027\026\004\036\027\017\016\b \017)Tj /Span<>> BDC ( )Tj EMC (\f\030\024\022\026\b \024\006\036\027\022\017, \021\024 \r)Tj /Span<>> BDC ( )Tj EMC (\024\021\027\024\001\036\027\017\017 )Tj 0.169 Tw T* (\027\026\004\017\n\024\f\021\017 \027\036\005\021\030\026\035\017\031\033\ \013\017\b \026\027\021\017\021\036\035, \036\007\017\027\024\005 \023\024\ \017)Tj 0 Tw (-)Tj 0.04 Tw 0 -1.218 TD (\006\017\017 \027\026)Tj /Span<>> BDC ( )Tj EMC (\f\036\020\024\007\027\016\001\027\017\005 \007\036\027\034 \027\036\021\ . \217\016\007 \017\f\f\035\036\007\024\r\026\027\017\005 \023\024)Tj 0 Tw (-)Tj 0.057 Tw 0 -1.218 TD (\022\026\026\035 \024\021\f\031\021\f\021\r\017\036 \r\035\017\016\027\017\ \016 \026\027\021\017\021\036\035 \027\026)Tj /Span<>> BDC ( )Tj EMC (\220\235\235\036\022\021\017\r\027\024\f\021\034 )Tj 0.09 Tw 0 -1.218 TD (\021\036\030\026\023\017\017 [12,15]. \203\026)Tj /Span<>> BDC ( )Tj EMC (\027\026\001 \r\020\035\016\007, \017\f\f\035\036\007\024\r\026\027\017\ \036 \026\027\021\017)Tj 0 Tw (-)Tj -0.002 Tw T* (\021\036\035 \016\r\035\016\036\021\f\016 \023\036\030\f\023\036\022\021\ \017\r\027\024\005 \026\007\026\004\036\005 \007\035\016 \007\026\035\034\ \027\036\005\001\017\b )Tj 0 Tw T* (\017\f\f\035\036\007\024\r\026\027\017\005.)Tj 0.232 Tw T* (\225\030\036\007\017 \035\026\002\024\030\026\021\024\030\027\t\b \021\036\ \f\021\024\r \007\035\016 \024\006\036\027\022\017 \220\235\235\036\022\021\ \017\r)Tj 0 Tw (-)Tj 0.142 Tw T* (\027\024\f\021\017 \021\036\030\026\023\017\017 \r)Tj /Span<>> BDC ( )Tj EMC (\027\026\f\021\024\016\013\036\036 \r\030\036\n\016 \026\022\021\017\r\027\ \024 \017\031\004\026\036\021)Tj 0 Tw (-)Tj 0.055 Tw T* (\f\016 \f\024\007\036\030\032\026\027\017\036 \r)Tj /Span<>> BDC ( )Tj EMC (\f\t\r\024\030\024\021\022\036 \017)Tj /Span<>> BDC ( )Tj EMC (\r \002\017\024\023\021\026\021\026\b \f\035\017\017\f\021\024\005 )Tj 0.058 Tw T* [(\024\002\024\035\024\004\022\017 )0.5(\021\024\035\f\021\024\005 )0.6(\022\017\001\022\017 )0.5(\024\027\022\024\f\021\026\021\017\027\026 )0.5(\204, )0.6(\016\r\035\016\033\013\036\020\024)]TJ 0 Tw (-)Tj 0.25 Tw T* [(\f\016 )0.5(\006\017\021\024\022\017\027\024\n )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC 7.768 0 Td [(\f\036\n\036\005\f\021\r\026 )0.5(\017\027\021\036\030\035\036\005\022\017\027\024\r-6, )0.7(\022\024\027)]TJ 0 Tw (-)Tj 0.24 Tw -7.768 -1.218 Td (\006\036\027\021\030\026\006\017\016 \022\024\021\024\030\024\020\024 \027\ \026\004\017\n\024 \023\024\r\t\001\026\036\021\f\016 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\030\026)Tj 0 Tw (-)Tj 0.094 Tw T* (\027\024\024\002\030\026\027\024\005 \017\n\n\031\027\027\024\005 \023\026\ \021\024\035\024\020\017\017, \r)Tj /Span<>> BDC ( )Tj EMC (\021\024\n \004\017\f\035\036 \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\017 )Tj -0.004 Tw T* (\200\003\025. \217\016\007 \023\031\002\035\017\022\026\006\017\005 \024\ \006\036\027\017\r\026\036\021 \030\024\035\034 \036\020\024 \023\035\026\ \n\036\027\027\024\005 )Tj 0.385 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\021\022\026\027\036\r\024\005 \022\024\027\006\036\027\021\030\026\006\017\ \017 \r)Tj /Span<>> BDC ( )Tj EMC (\022\026\004\036\f\021\r\036 \023\030\036\007\017\022\021\024\030\026 )Tj 0.369 Tw T* [(\220\235\235\036\022\021\017\r\027\024\f\021\017 )0.6(\021\036\030\026\023\017\017 )0.5(\017\027\020\017\002\017\021\024\030\026\n\017 )0.5(\205\203\210-\026\035\034\235\026 )]TJ 0.208 Tw T* ([16\22618]. \213\f\035\017 \002\031\007\036\021 \007\024\022\026\026\027\ \026 \036\020\024 \023\030\024\020\027\024\f\021\017\004\036\f\022\026\016\ )Tj 0.326 Tw T* (\027\026\004\017\n\024\f\021\034, \022\035\017\027\017\006\017\f\021\t \ \023\024\035\031\004\026\021 \b\024\030\024\001\017\005 \017\027\f\021\030\ \031)Tj 0 Tw (-)Tj 0.164 Tw T* [(\n\036\027\021 )0.5(\007\035\016 )0.6(\024\006\036\027\022\017 )0.5(\006\036\035\036\f\024\024\002\030\026\027\024\f\021\017 )0.6(\027\026\004\026\035\026 )0.5(\021\036\030\026\023\017\017 )]TJ 0 Tw T* (\220\021\024\005 \020\030\031\023\023\024\005 \023\030\036\023\026\030\026\ \021\024\r.)Tj 0.352 Tw T* (\212\030\031\020\017\n \n\026\030\022\036\030\024\n, \022\024\021\024\030\ \t\005 \017\031\004\026\036\021\f\016 \007\035\016 \024\006\036\027\022\ \017 )Tj 0.481 Tw T* [(\r\036\030\024\016\021\027\024\f\021\017 )0.6(\220\235\235\036\022\021\017\r\027\024\005 )0.6(\021\036\030\026\023\017\017 )0.5(\017\027\020\017\002\017\021\024\030\026\n\017 )]TJ 0.079 Tw T* (\205\203\210-\026\035\034\235\026 \023\036\030\036\007 \027\026\004\026\035\ \024\n \021\036\030\026\023\017\017, \016\r\035\016\036\021\f\016 TREM1,\ )Tj 0.187 Tw T* (\023\030\036\007\f\021\026\r\035\016\033\013\017\005 \f\024\002\024\005 \ \030\036\006\036\023\021\024\030, \220\022\f\023\030\036\f\f\017\030\031\ \036\n\t\005 )Tj -0.047 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC (\023\024\r\036\030\b\027\024\f\021\017 \n\024\027\024\006\017\021\024\r \ \017)Tj /Span<>> BDC ( )Tj EMC (\027\036\005\021\030\024\235\017\035\024\r \r)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\006\036\f\f\036 )Tj -0.045 Tw T* (\r\024\f\023\026\035\036\027\017\016. \200)Tj /Span<>> BDC ( )Tj EMC (\017\f\f\035\036\007\024\r\026\027\017\017 \f)Tj /Span<>> BDC ( )Tj EMC (\031\004\026\f\021\017\036\n 54 \023\026\006\017\036\027\021\024\r )Tj 0.122 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\200\003\025 \023\024\022\026\026\027\024, \004\021\024 \027\017\022\017\ \036 \023\035\026\n\036\027\027\t\036 \017)Tj /Span<>> BDC ( )Tj EMC (\021\022\026\027\036\r\t\036 )Tj T* (\022\024\027\006\036\027\021\030\026\006\017\017 TREM1 \016\r\035\016\035\ \017\f\034 \235\026\022\021\024\030\026\n\017, \026\f\f\024\006\017\017)Tj 0 Tw (-)Tj -0.001 Tw T* (\030\024\r\026\027\027\t\n\017 \f)Tj /Span<>> BDC ( )Tj EMC (\024\021\r\036\021\024\n \027\026)Tj /Span<>> BDC ( )Tj EMC (\021\036\030\026\023\017\033 \017\027\020\017\002\017\021\024\030\026\n\017\ \205\203\210, )Tj -0.011 Tw T* (\023\030\017)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\n \036\020\024 \031\030\024\r\036\027\034 \027\036 \r\035\017\ \016\035 \027\026)Tj /Span<>> BDC ( )Tj EMC (\017\f\b\024\007\t \021\036\030\026\023\017\017 \r\036)Tj 0 Tw (-)Tj T* (\007\024\035\017\031\n\026\002\024\n \017)Tj /Span<>> BDC ( )Tj EMC (\031\f\021\036\022\017\027\031\n\026\002\024\n [19].)Tj 0.067 Tw T* (\200 \017\f\f\035\036\007\024\r\026\027\017\017, \024\023\031\002\035\017\ \022\024\r\026\027\027\024\n \r)Tj /Span<>> BDC ( )Tj EMC (2021)Tj /Span<>> BDC ( )Tj EMC (\020., \023\024\035\024\032\017)Tj 0 Tw (-)Tj 0.055 Tw T* (\021\036\035\034\027\t\n\017 \023\030\024\020\027\024\f\021\017\004\036\f\ \022\017\n\017 \235\026\022\021\024\030\026\n\017, \r\035\017\016\033\013\ \017\n\017 )Tj 0.17 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC (\021\036\030\026\023\017\033 \224\203\205, \002\t\035\017 \023\024\022\026\ \026\027\t: \r\t\f\024\022\026\016 \f\t\r\024\030\024)Tj 0 Tw (-)Tj 0.278 Tw T* [(\021\024\004\027\026\016 )0.5(\022\024\027\006\036\027\021\030\026\006\017\016 )0.5(\200-\022\035\036\021\024\004\027\024\020\024 )0.5(\026\022\021\017\r\017\030\031\033\013\036\020\024 )]TJ -0.042 Tw T* (\235\026\022\021\024\030\026 $BAFF$, \026 \021\026\022\032\036 \020\036\ \027\024\021\017\023\t \231\202 \017)Tj /Span<>> BDC ( )Tj EMC (\202\202 \026\035\035\036\035\017 \020\036\027\026 )Tj 0 Tw T* [(r)-10(s1041569, \022\024\007\017\030\031\033\013\017\b \036\020\024 \f\017\027\ \021\036 [20].)]TJ /T1_1 1 Tf T* (\021\002\b\003\006\002\f\001\b\013\r \003\002\201\220\t \236\226\226\r\220\ \003\t\b\002\217\003\t \003\r\006\004\212\t\t)Tj /T1_2 1 Tf 0.068 Tw T* (\203\036\n\026\035\024\r\026\032\027\t\n \024\f\021\026\033\021\f\016 \023\ \030\024\002\035\036\n\t, \022\026\f\026\033\013\017\036\f\016 \n\036)Tj 0 Tw (-)Tj 0.061 Tw T* (\021\024\007\024\r \017)Tj /Span<>> BDC ( )Tj EMC (\f\030\024\022\024\r \024\006\036\027\022\017 \220\235\235\036\022\021\017\ \r\027\024\f\021\017 \021\036\030\026\023\017\017 \224\203\205 )Tj 0.016 Tw T* [(\017, \022\026\022 \f\035\036\007\f\021\r\017\036, \021\026\022\017\b \021\ \036\030\n\017\027\024\r, \022\026\022 \253\023\036\030\r\017\004\027\026\ \016 )0.5(\027\036)]TJ 0 Tw (-)Tj 0.011 Tw T* (\220\235\235\036\022\021\017\r\027\024\f\021\034\273 \017)Tj /Span<>> BDC ( )Tj EMC (\253\023\024\021\036\030\016 \024\021\r\036\021\026\273. \215\024\f\035\036\ \007\027\017\036 \023\024\027\016)Tj 0 Tw (-)Tj 0.08 Tw T* (\021\017\016 \022\030\026\005\027\036 \r\026\032\027\t \r)Tj /Span<>> BDC ( )Tj EMC (\r\024\023\030\024\f\036 \r\021\024\030\024\005 \017)Tj /Span<>> BDC ( )Tj EMC (\023\024\f\035\036\007\031\033\013\036\005 )Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 0 Tw 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\205)10(\210\036\033 \035\030\032\204\033)30(\021)42(\032)-21(\211\033\237)]TJ 57.136 0 Td (REVIEW)Tj /T1_3 1 Tf 25 0 0 25 505.5021 56.0378 Tm (175)Tj ET endstream endobj 546 0 obj <>stream q /GS0 gs /Fm0 Do Q 0 0 0 1 K /GS1 gs q 1 0 0 1 70.8661 691.916 cm 0 0 m 453.543 0 l S Q BT 0 0 0 1 k /T1_0 1 Tf 0.01 Tc 8 0 0 8 70.9061 731.2159 Tm [(\021\024\027\030\026)5( \024\033\023)5( \030\027\030\032\026\037\032:)]TJ /T1_1 1 Tf 0 Tc 0.005 Tw 10.541 0 Td ( \223\027\016\021\024\037\020\004\033\034\036 \205.\222., \233\221\006\240\ \253\002\203\200\214 \021\034\027\034\f\033\034\021\035\034\027\034\013\ \022\022 \022\003\016\020\022 \223.\002.)Tj /Span<>> BDC ( )Tj EMC (\210\032\t\022\273 \203\022\020\031\004\033\037\036\037 \210\034\024\024\ \022\022, \023\027.)Tj /Span<>> BDC ( )Tj EMC (\217\037\027\030\003\037 \223\004\022\027\030, \004.)Tj /Span<>> BDC ( )Tj EMC (2, )Tj 0.023 Tw -10.546 -1.2 Td (\203\034\024\021\036\037, 123423, \210\034\024\024\022\030;)Tj /Span<>> BDC ( )Tj EMC (+7 917 518 82 94; e-mail: aleksandrov_tl@gnck.ru)Tj /T1_0 1 Tf 0.01 Tc 0.016 Tw 0.005 -1.2 Td [(ADDRESS)5( F)13(OR)5( C)19(ORRESPONDEN)23(CE:)]TJ /T1_1 1 Tf 0 Tc 0.021 Tw 14.046 0 Td [( Alek)-22.9(sandrov T)63(.L., Ryzhikh N)18(ational Medical R)21(esearch Center of Colop)46.1(roctology)42(, Salyama Adilya st., 2, Moscow)52(, )]TJ 0.023 Tw -14.051 -1.2 Td [(123423, R)22(ussia;)]TJ /Span<>> BDC ( )Tj EMC [(+7 917 518 82 94; e-mail: alek)-22.9(sandrov_tl@gnck.ru)]TJ 0 Tw 0 -2.792 TD (\007\037\035\037 \f\034\024\035\023\f\027\016\020\022\030)Tj /Span<>> BDC ( )Tj EMC (\227 30.01.2024)Tj /Span<>> BDC ( )Tj EMC 19.488 0 Td (\207\034\024\027\016 \004\034\033\037\025\034\035\021\022)Tj /Span<>> BDC ( )Tj EMC (\227 18.03.2024)Tj /Span<>> BDC ( )Tj EMC 18.78 0 Td (\207\033\022\020\030\035\034 \021)Tj /Span<>> BDC ( )Tj EMC (\f\023\025\027\022\021\037\n\022\022)Tj /Span<>> BDC ( )Tj EMC (\227 24.04.2024)Tj ( )Tj -38.268 -1.375 Td (Received)Tj /Span<>> BDC ( )Tj EMC (\227 30.01.2024)Tj /Span<>> BDC ( )Tj EMC 19.488 0 Td (Revised)Tj /Span<>> BDC ( )Tj EMC (\227 18.03.2024)Tj /Span<>> BDC ( )Tj EMC 18.78 0 Td (Accepted for publication)Tj /Span<>> BDC ( )Tj EMC (\227 24.04.2024)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 70.936 627.4059 Tm (\023\023\034\226\034\022\031\034)Tj 0 0 0 1 k /GS1 gs /T1_3 1 Tf 0 Tc 0.349 Tw 10 0 0 10 70.8661 603.0499 Tm (\200\024\f\023\026\035\017\021\036\035\034\027\t\036 \026\002\024\035\036\ \r\026\027\017\016 \022\017\001\036\004\027\017\022\026)Tj /Span<>> BDC ( )Tj EMC (\227 \020\030\031\023)Tj 0 Tw (-)Tj 0.194 Tw 0 -1.218 TD (\023\026 \026\002\024\035\036\r\026\027\017\005, \r\022\035\033\004\026\ \033\013\026\016 \016\r\036\027\027\t\005 \022\024\035\017\021 $\242\025\ $ )Tj 0.413 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\036\027\034 \025\030\024\027\026 $\207\025$, \022\024\021\ \024\030\t\036 \b\026\030\026\022\021\036\030\017\031\033\021\f\016 )Tj 0.11 Tw 0 -1.218 TD (\220\030\024\017\r\027\024-\016\r\036\027\027\t\n \023\024\030\026\032\ \036\027\017\036\n \f\021\036\027\022\017 \032\036\035\031\007\024\004\027\ \024-)Tj 0.336 Tw 0 -1.218 TD (\022\017\001\036\004\027\024\020\024 \021\030\026\022\021\026 \030\026\035\ \017\004\027\024\005 \f\021\036\023\036\027\017 \r\t\030\026\032\036\027\ \027\024)Tj 0 Tw (-)Tj 0.14 Tw 0 -1.218 TD [(\f\021\017 )0.5([1]. )0.5(\200)]TJ /Span<>> BDC ( )Tj EMC 4.534 0 Td [(\035\036\004\036\027\017\017 )0.6(\021\016\032\036\035\t\b )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 8.573 0 Td [(\f\030\036\007\027\036\021\016\032\036\035\t\b )0.6(\235\024\030\n )]TJ 0.141 Tw -13.108 -1.218 Td (\r)Tj /Span<>> BDC ( )Tj EMC (\027\026\f\021\024\016\013\036\036 \r\030\036\n\016 \026\022\021\017\r\027\ \024 \023\030\017\n\036\027\016\033\021\f\016 \020\036\027\027\024-\017\027\ )Tj 0 Tw (-)Tj 0.426 Tw 0 -1.218 TD (\032\036\027\036\030\027\t\036 \002\017\024\035\024\020\017\004\036\f\022\ \017\036 \023\030\036\023\026\030\026\021\t \017)Tj /Span<>> BDC ( )Tj EMC (\021\026\030\020\036\021\027\t\036 )Tj 0.358 Tw 0 -1.218 TD (\017\n\n\031\027\024\f\031\023\030\036\f\f\024\030\t. \231\036\n \027\036\ \n\036\027\036\036, \220\235\235\036\022\021\017\r\027\024\f\021\034 )Tj 0.129 Tw 0 -1.218 TD (\206\224\207\215 \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r, \022\024\021\024\030\t\n \024\027\017\ \027\026\027\026\004\026\033\021\f\016, \007\026\035\036)Tj 0 Tw (-)Tj 0.146 Tw T* (\022\026 \024\021 \017\007\036\026\035\034\027\024\005. \203\036\030\036\ \007\022\017 \f\035\031\004\026\017 \027\036\220\235\235\036\022\021\017\ \r\027\024\f\021\017 )Tj 0.382 Tw 0 -1.218 TD (2\2263)Tj /Span<>> BDC ( )Tj EMC (\023\024\f\035\036\007\024\r\026\021\036\035\034\027\024 \027\026\027\026\ \004\036\027\027\t\b \023\026\006\017\036\027\021\031 \023\030\036)Tj 0 Tw (-)Tj 0.326 Tw 0 -1.218 TD (\023\026\030\026\021\024\r. \215\024\n\017\n\024 \024\023\017\f\026\027\027\ \024\005 \r\t\001\036 \023\036\030\r\017\004\027\024\005 \027\036)Tj 0 Tw (-)Tj 0.684 Tw 0 -1.218 TD (\220\235\235\036\022\021\017\r\027\024\f\021\017 \002\017\024\035\024\020\ \017\004\036\f\022\017\b \026\020\036\027\021\024\r, \027\036\030\036\007\ \022\024 )Tj -0.03 Tw 0 -1.218 TD (\r\f\021\030\036\004\026\036\021\f\016 \017)Tj /Span<>> BDC ( )Tj EMC (\023\024\021\036\030\016 \024\021\r\036\021\026. \215\024\007 \023\024\021\ \036\030\036\005 \024\021\r\036\021\026 \023\024\007)Tj 0 Tw (-)Tj -0.03 Tw 0 -1.218 TD [(\030\026\031\n\036\r\026\036\021\f\016 )0.6(\f\024\f\021\024\016\027\017\036, )0.5(\023\030\017)]TJ /Span<>> BDC ( )Tj EMC 12.103 0 Td [(\022\024\021\024\030\024\n )0.5(\023\024\f\035\036 )0.5(\017\027\007\031\022\006\017)]TJ 0 Tw (-)Tj 0.125 Tw -12.103 -1.218 Td (\024\027\027\024\020\024 \022\031\030\f\026 \206\224\207\215 \017\035\017\ \231\224\225 \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\026 \031\007\026\036\021\f\016 \007\024)Tj 0 Tw (-)Tj -0.016 Tw 0 -1.218 TD (\002\017\021\034\f\016 \f\021\024\005\022\024\005 \022\035\017\027\017\022\ \024-\017\027\f\021\030\031\n\036\027\021\026\035\034\027\024\005 \030\036\ \n\017\f\f\017\017 )Tj 0.225 Tw 0 -1.218 TD (\r\024\f\023\026\035\017\021\036\035\034\027\024\020\024 \023\030\024\006\ \036\f\f\026, \027\024 \f)Tj /Span<>> BDC ( )Tj EMC (\021\036\004\036\027\017\036\n \r\030\036\n\036\027\017 )Tj 0 Tw 0 -1.218 TD (\023\030\024\017\f\b\024\007\017\021 \030\036\006\017\007\017\r \026\002\ \024\035\036\r\026\027\017\016.)Tj 0.192 Tw 0 -1.218 TD (\215\024\022\026\026\027\017\016\n\017 \022)Tj /Span<>> BDC ( )Tj EMC (\027\026\004\026\035\031 \021\036\030\026\023\017\017 \206\224\207\215 \017\ \035\017 \231\224\225 \f\035\031)Tj 0 Tw (-)Tj 0.344 Tw 0 -1.218 TD (\032\026\021 \027\036\220\235\235\036\022\021\017\r\027\024\f\021\034 \002\ \026\017\f\027\024\005 \021\036\030\026\023\017\017 \023\030\036\023\026\ \030\026)Tj 0 Tw (-)Tj 0.174 Tw 0 -1.218 TD (\021\026\n\017 5-\026\n\017\027\024\f\026\035\017\006\017\035\024\r\024\005\ \022\017\f\035\024\021\t $\007\035\016 \242\025$, \017\n\n\031)Tj 0 Tw (-)Tj 0.395 Tw 0 -1.218 TD (\027\024\f\031\023\030\036\f\f\024\030\024\r, \f\017\f\021\036\n\027\t\b\ \020\035\033\022\024\022\024\030\021\017\022\024\f\021\036\030\024\017\007\ \024\r )Tj 0.116 Tw 0 -1.218 TD ($\f\206\025\225$, \027\036\023\036\030\036\027\024\f\017\n\024\f\021\034\ \017\035\017 \027\036\r\024\n\024\032\027\024\f\021\034 \023\030\024\r\ \036)Tj 0 Tw (-)Tj 0.105 Tw 0 -1.218 TD (\007\036\027\017\016 \021\036\030\026\023\017\017 \220\021\017\n\017 \f\030\ \036\007\f\021\r\026\n\017, \026)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\032\036 \026\020\030\036\f\f\017\r)Tj 0 Tw (-)Tj 0.041 Tw 0 -1.218 TD (\027\024\036 \021\036\004\036\027\017\036 \026\002\024\035\036\r\026\027\ \017\016. \215\030\017)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\n \253\026\020\030\036\f\f\017\r\027\024\f\021\034\273 )Tj 0.328 Tw 0 -1.218 TD (\021\036\004\036\027\017\016 \026\002\024\035\036\r\026\027\017\016 \026\ \004\026\f\021\031\033 \016\r\035\016\036\021\f\016 \007\024\r\024\035\034\ \027\024 )Tj 0.255 Tw 0 -1.218 TD [(\f\031\002\255\036\022\021\017\r\027\t\n )0.6(\235\026\022\021\024\030\024\n. )0.5(\200)]TJ /Span<>> BDC ( )Tj EMC 12.217 0 Td [(\027\026\f\021\024\016\013\017\005 )0.6(\n\024\n\036\027\021 )0.5(\r\t)]TJ 0 Tw (-)Tj 0.195 Tw -12.217 -1.218 Td [(\002\024\030 \022\024\027\022\030\036\021\027\024\020\024 \206\224\207\215\ \017\035\017 \231\224\225 \007\035\016 \035\036\004\036\027\017\016 )0.5(\023\026\006\017)]TJ 0 Tw (-)Tj 0.128 Tw 0 -1.218 TD (\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\200\003\025 \027\026\023\024\n\017\027\026\036\021 \027\036\022\024\036\ \253\023\024\023\026\007\026\027\017\036 \023\026\035\034\006\036\n )Tj 0.013 Tw 0 -1.218 TD (\r)Tj /Span<>> BDC ( )Tj EMC (\027\036\002\024\273. \025\030\024\n\036 \021\024\020\024, \024\f\021\026\ \036\021\f\016 \027\036\016\f\027\t\n, \031)Tj /Span<>> BDC ( )Tj EMC (\022\026\022\017\b \002\024\035\034)Tj 0 Tw (-)Tj 0.15 Tw 0 -1.218 TD (\027\t\b \017)Tj /Span<>> BDC ( )Tj EMC (\r \022\026\022\017\036 \f\030\024\022\017 \023\030\024\017\r\024\007\017\ \021\034 \022\024\027\021\030\024\035\034 \220\235\235\036\022)Tj 0 Tw (-)Tj 0.17 Tw 0 -1.218 TD (\021\017\r\027\024\f\021\017 \021\036\030\026\023\017\017. \203\036\016\f\ \027\024, \022\026\022\017\036 \n\036\021\024\007\t \017\f\023\024\035\034\ \024)Tj 0 Tw (-)Tj 0.196 Tw 0 -1.218 TD (\r\026\021\034 \007\035\016 \024\006\036\027\022\017, \004\021\024 \023\030\ \017\027\017\n\026\021\034 \026)Tj /Span<>> BDC ( )Tj EMC (\023\024\035\024\032\017\021\036\035\034\027\031\033 )Tj 0.086 Tw 0 -1.218 TD (\007\017\027\026\n\017\022\031, \017)Tj /Span<>> BDC ( )Tj EMC (\022\024\020\007\026 \032\007\026\021\034 \022\035\017\027\017\022\024-\017\ \027\f\021\030\031\n\036\027\021\026\035\034\027\024\005 )Tj 0.146 Tw 0 -1.218 TD (\030\036\n\017\f\f\017\017. \215\024)Tj /Span<>> BDC ( )Tj EMC (\f\036\005 \007\036\027\034 \r)Tj /Span<>> BDC ( )Tj EMC (\017\027\007\031\022\006\017\017 \030\036\n\017\f\f\017\017 \023\026\006\ \017)Tj 0 Tw (-)Tj 0.167 Tw 0 -1.218 TD (\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC [(\200\003\025 \026\022\021\017\r\027\024 \017\f\023\024\035\034\031\036\021\ \f\016 )0.5(\f\206\025\225 \017)]TJ /Span<>> BDC ( )Tj EMC (\026\004\026\f\021\031\033 )Tj 0.149 Tw 0 -1.218 TD (\206\224\207\215 \017)Tj /Span<>> BDC ( )Tj EMC (\231\224\225 \017\027\017\006\017\017\030\031\033\021\f\016 \023\026\030\ \026\035\035\036\035\034\027\024 \f)Tj /Span<>> BDC ( )Tj EMC (\021\036\030\026\023\017\036\005 )Tj 0.201 Tw 0 -1.218 TD (\020\024\030\n\024\027\026\n\017. \225\021\024\017\021 \024\021\n\036\021\ \017\021\034, \004\021\024 \r)Tj /Span<>> BDC ( )Tj EMC (\030\036\020\017\f\021\030\026\006\017\024\027\027\t\b )Tj -0.009 Tw 0 -1.218 TD (\022\035\017\027\017\004\036\f\022\017\b \017\f\023\t\021\026\027\017\016\ \b \r\f\036\b \f\024\r\030\036\n\036\027\027\t\b \023\030\036\023\026\030\ \026)Tj 0 Tw (-)Tj 0.051 Tw 0 -1.218 TD (\021\024\r \035\036\004\036\027\017\036 \f\206\025\225 \016\r\035\016\035\ \024\f\034 \253\026\023\030\036\013\036\027\027\024\005 \021\036\030\026\ \023\017\036\005\273 )Tj 0.111 Tw 0 -1.218 TD (\017)Tj /Span<>> BDC ( )Tj EMC (\023\024\220\021\024\n\031 \017\b \220\235\235\036\022\021\017\r\027\024\ \f\021\034 \024\006\036\027\017\r\026\035\026\f\034 \002\036 \031\004\036\ \021\026 )Tj 0.181 Tw 0 -1.218 TD (\r\024\n\024\032\027\024\f\021\017 \f\027\017\032\036\027\017\016 \r\024\ \f\023\026\035\017\021\036\035\034\027\024\005 \026\022\021\017\r\027\024\ \f\021\017 )Tj 0.164 Tw 23.244 56.019 Td (\206\025\225. \025\030\024\n\036 \021\024\020\024, \r)Tj /Span<>> BDC ( )Tj EMC (\030\036\026\035\034\027\024\005 \022\035\017\027\017\004\036\f\022\024\005\ \023\030\026\022\021\017\022\036 )Tj -0.045 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\024\f\027\024\r\027\024\n \r\f\021\030\036\004\026\033\021\f\016 \023\026\ \006\017\036\027\021\t, \022\024\021\024\030\t\036 \027\036 \023\024\007\ \b\024)Tj 0 Tw (-)Tj 0.013 Tw T* (\007\016\021 \023\024)Tj /Span<>> BDC ( )Tj EMC (\022\030\017\021\036\030\017\016\n \r\022\035\033\004\036\027\017\016/\017\ \f\022\035\033\004\036\027\017\016 \r)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\021\024\022\024)Tj 0 Tw (-)Tj 0.051 Tw 0 -1.218 TD (\035\t \022\035\017\027\017\004\036\f\022\017\b \017\f\023\t\021\026\027\ \017\005 \r)Tj /Span<>> BDC ( )Tj EMC (\f\r\016\017 \f)Tj /Span<>> BDC ( )Tj EMC (\f\024\023\031\021\f\021\r\031\033\013\036\005 )Tj 0.298 Tw 0 -1.218 TD (\023\026\021\024\035\024\020\017\036\005 \017\035\017 \021\016\032\036\f\ \021\034\033 \024\f\027\024\r\027\024\020\024 \026\002\024\035\036\r\026\ \027\017\016. )Tj 0.095 Tw T* (\225\024 \r\f\036\n \r\t\001\036\f\022\026\026\027\027\t\n \f\r\016\026\ \027\026 \027\036\024\002\b\024\007\017\n\024\f\021\034 \023\024)Tj 0 Tw (-)Tj 0.092 Tw T* (\017\f\022\026, \r\024-\023\036\030\r\t\b, \235\026\022\021\024\030\024\r\ , \024\023\030\036\007\036\035\016\033\013\017\b \027\026\017\002\024\035\ \036\036 )Tj 0.327 Tw T* [(\002\035\026\020\024\023\030\017\016\021\027\t\005 )0.5(\023\030\024\020\027\024 \r)]TJ /Span<>> BDC ( )Tj EMC (\024\021\027\024\001\036\027\017\017 \027\026\f\021\031\023\035\036\027\017\ \016 )Tj 0.156 Tw 0 -1.218 TD (\030\036\n\017\f\f\017\017 \007\035\016 \030\026\035\017\004\027\t\b \206\ \224\207\215 \017)Tj /Span<>> BDC ( )Tj EMC (\231\224\225, \026, \r\024-\r\021\024\030\t\b, )Tj 0.071 Tw 0 -1.218 TD [(\r\024\n\024\032\027\024\f\021\036\005 \024\023\021\017\n\017\026\006\017\ \017 )0.5(\021\036\030\026\023\017\017 \220\021\017\n\017 \023\030\036\023\026\030\ \026)]TJ 0 Tw (-)Tj 0 -1.218 TD (\021\026\n\017 [2].)Tj 0.002 Tc 0.193 Tw 0 -1.218 TD [(\224\027\235\035\017\022\f\017\n\026\002 $\224\203\205$ \023\030\036\007\ \f\021\026\r\035\016\036\021 \f\024\002\024\005 \b\017\n\036\030\027\024\ \036)2( )]TJ -0.039 Tw 0 -1.218 TD (\n\024\027\024\022\035\024\027\026\035\034\027\024\036 \026\027\021\017\021\ \036\035\024, \017\027\020\017\002\017\030\031\033\013\036\036 \235\026\022\ \021\024\030 \027\036)Tj 0 Tc 0 Tw (-)Tj 0.002 Tc -0.024 Tw 0 -1.218 TD (\022\030\024\026 \024\023\031\b\024\035\017 \026\035\034\235\026 $\205\ \203\210-\026$. \215\036\030\r\t\036 \007\026\027\027\t\036 \024\002 \220\ \235)Tj 0 Tc 0 Tw (-)Tj 0.002 Tc -0.06 Tw T* (\235\036\022\021\017\r\027\024\f\021\017 \220\021\024\020\024 \206\224\207\ \215 \024\023\031\002\035\017\022\024\r\026\027\t \r)Tj /Span<>> BDC ( )Tj EMC (1994 \020. \017)Tj /Span<>> BDC ( )Tj EMC (\022\026)Tj 0 Tc 0 Tw (-)Tj 0.002 Tc 0.003 Tw T* (\f\026\035\017\f\034 \035\036\004\036\027\017\016 \030\036\r\n\026\021\024\ \017\007\027\024\020\024 \026\030\021\030\017\021\026 [3]. \200)Tj /Span<>> BDC ( )Tj EMC [(1997 \020.)2.1( )]TJ -0.044 Tw T* [(\023\024\016\r\035\016\033\021\f\016 \023\031\002\035\017\022\026\006\017\ \017 \022\024\030\024\021\022\017\b \f\036\030\017\005 \022\035\017\027\017\ \004\036\f\022\017\b)2( )]TJ 0.023 Tw T* (\027\026\002\035\033\007\036\027\017\005 \017)Tj /Span<>> BDC ( )Tj EMC (\027\036\002\024\035\034\001\017\036 \017\f\f\035\036\007\024\r\026\027\017\ \016 \224\203\205 \023\030\017)Tj /Span<>> BDC ( )Tj EMC [(\207\025)2( )]TJ 0.114 Tw T* ([4]. \200)Tj /Span<>> BDC ( )Tj EMC (2002 \020. \024\023\031\002\035\017\022\024\r\026\027\t \030\036\031\035\ \034\021\026\021\t \017\f\f\035\036\007\024\r\026)Tj 0 Tc 0 Tw (-)Tj 0.002 Tc 0.06 Tw T* [(\027\017\016 A)16(CCENTI, \r)]TJ /Span<>> BDC ( )Tj EMC [(\022\024\021\024\030\024\n \024\006\036\027\017\r\026\035\026\f\034 \220\ \235\235\036\022\021\017\r\027\024\f\021\034)2( )]TJ 0.161 Tw T* (\224\203\205 \f\030\026\r\027\017\021\036\035\034\027\024 \f)Tj /Span<>> BDC ( )Tj EMC (\023\035\026\006\036\002\024 \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\026\022\021\017\r)Tj 0 Tc 0 Tw (-)Tj 0.002 Tc 0.284 Tw T* (\027\024\005 \207\025. \200)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\n \017\f\f\035\036\007\024\r\026\027\017\017 \220\235\235\036\ \022\021\017\r\027\024\f\021\034 \017\027)Tj 0 Tc 0 Tw (-)Tj 0.002 Tc 0.089 Tw T* (\007\031\022\006\017\024\027\027\024\020\024 \022\031\030\f\026 \f\024\f\ \021\026\r\017\035\026 58%, \026)Tj /Span<>> BDC ( )Tj EMC [(\r \021\036\004\036\027\017\036 \020\024\007\026)2( )]TJ 0.135 Tw T* (\023\030\036\023\026\030\026\021 \024\f\021\026\r\026\035\f\016 \220\235\ \235\036\022\021\017\r\027\t\n \031)Tj /Span<>> BDC ( )Tj EMC [(45% \023\026\006\017\036\027\021\024\r)2( )]TJ 0.107 Tw T* ([5]. \200)Tj /Span<>> BDC ( )Tj EMC [(\017\f\f\035\036\007\024\r\026\027\017\016\b A)16(CTI \017)]TJ /Span<>> BDC ( )Tj EMC [(A)16(CTII, \024\023\031\002\035\017\022\024\r\026\027\027\t\b)2( )]TJ 0.116 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (2005 \020., \017\f\f\035\036\007\024\r\026\035\026\f\034 \220\235\235\036\ \022\021\017\r\027\024\f\021\034 \017)Tj /Span<>> BDC ( )Tj EMC (\002\036\024\023\026\f)Tj 0 Tc 0 Tw (-)Tj 0.002 Tc 0.167 Tw T* (\027\024\f\021\034 \224\203\205 \007\035\016 \017\027\007\031\022\006\017\ \017 \017)Tj /Span<>> BDC ( )Tj EMC [(\023\024\007\007\036\030\032\026\027\017\016 \030\036\n\017\f\f\017\017)2( )]TJ 0.069 Tw T* (\031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\242\025. \212\017\026\005\027 \002\t\035 \023\024\b\024\032\017\n \027\ \026)Tj /Span<>> BDC ( )Tj EMC [(A)16(CCENTI.)2( )]TJ -0.009 Tw T* [(\230\235\235\036\022\021\017\r\027\024\f\021\034 \017\027\007\031\022\006\ \017\024\027\027\024\020\024 \022\031\030\f\026 \f\024\f\021\026\r\017\035\ \026 69%,)2( )]TJ -0.013 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC [(\031 45% \023\026\006\017\036\027\021\024\r \023\030\036\023\026\030\026\ \021 \024\f\021\026\r\026\035\f\016 \220\235\235\036\022\021\017\r\027\t\ \n)2( )]TJ 0 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\021\036\004\036\027\017\036 \020\024\007\026 \027\026\002\035\033\007\036\ \027\017\016 [6]. \203\036\f\n\024\021\030\016 \027\026)Tj /Span<>> BDC ( )Tj EMC (\f\030\026\r\027\017)Tj 0 Tc (-)Tj 0.002 Tc -0.004 Tw T* (\021\036\035\034\027\024 \r\t\f\024\022\031\033 \004\026\f\021\024\021\031\ \022\035\017\027\017\004\036\f\022\024\020\024 \024\021\r\036\021\026 \027\ \026)Tj /Span<>> BDC ( )Tj EMC (\023\030\024)Tj 0 Tc 0 Tw (-)Tj 0.002 Tc 0.188 Tw T* (\021\016\032\036\027\017\017 \017\027\007\031\022\006\017\024\027\027\024\ \020\024 \022\031\030\f\026 \017)Tj /Span<>> BDC ( )Tj EMC [(\002\t\f\021\030\031\033 \f\022\024\030\024\f\021\034)2( )]TJ 0.158 Tw T* (\030\026\r\017\021\017\016 \022\035\017\027\017\004\036\f\022\024\020\024\ \024\021\r\036\021\026, \r\t\032\017\r\026\036\n\024\f\021\034 \021\036\ \030\026)Tj 0 Tc 0 Tw (-)Tj 0.002 Tc 0.197 Tw T* [(\023\017\017 \024\f\021\026\r\035\016\036\021 \032\036\035\026\021\034 )0.5(\035\031\004\001\036\020\024 [7]. \224)]TJ /Span<>> BDC ( )Tj EMC (\024\021\030\017\006\026\021\036\035\034)Tj 0 Tc 0 Tw (-)Tj 0.002 Tc 0.296 Tw T* (\027\t\b \b\026\030\026\022\021\036\030\017\f\021\017\022 \023\030\036\023\ \026\030\026\021\026 \026\f\035\031\032\017\r\026\036\021 \r\027\017\n\026\ )Tj 0 Tc 0 Tw (-)Tj 0.002 Tc 0.106 Tw T* (\027\017\036 \017)Tj /Span<>> BDC ( )Tj EMC [(\r\024\023\030\024\f \002\036\024\023\026\f\027\024\f\021\017 \021\036\030\ \026\023\017\017. \224\203\205 \007\024\r\024\035\034\027\024)2( )]TJ 0.13 Tw T* [(\017\n\n\031\027\024\020\036\027\036\027, \004\021\024 \016\r\035\016\036\ \021\f\016 \023\030\017\004\017\027\024\005 \022\026\022 \235\036\027\024\ \n\036\027\026)2( )]TJ 0.134 Tw T* (\253\023\024\021\036\030\017 \024\021\r\036\021\026\273, \021\026\022 \017\ )Tj /Span<>> BDC ( )Tj EMC (\r\t\f\024\022\024\005 \004\026\f\021\024\021\t \026\035\035\036\030\020\ \017\004\036)Tj 0 Tc 0 Tw (-)Tj 0.002 Tc 0 -1.218 TD (\f\022\017\b \030\036\026\022\006\017\005 [8,9].)Tj 0 Tc 0.171 Tw 0 -1.218 TD (\200\f\036 \r\t\001\036\f\022\026\026\027\027\024\036 \021\030\036\002\031\ \036\021 \031\021\024\004\027\036\027\017\016 \006\036\035\024\020\024 \030\ \016\007\026 )Tj 0.055 Tw 0 -1.218 TD (\r\024\023\030\024\f\024\r, \027\026\023\030\026\r\035\036\027\027\t\b \027\ \026)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\f\024\027\017\235\017\022\026\006\017\033 \027\026\027\026\ )Tj 0 Tw (-)Tj 0.141 Tw 0 -1.218 TD [(\004\036\027\017\016 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC [(\030\036\032\017\n\024\r )0.5(\021\036\030\026\023\017\017 \224\203\205. \215\024-\023\030\036\032\027\ \036\n\031 )0.5(\024\f\021\026)]TJ 0 Tw (-)Tj 0.207 Tw 0 -1.218 TD (\033\021\f\016 \026\022\021\031\026\035\034\027\t\n\017 \023\030\024\002\ \035\036\n\t, \f\r\016\026\027\027\t\036 \f)Tj /Span<>> BDC ( )Tj EMC (\024\006\036\027\022\024\005 )Tj 0.238 Tw 0 -1.218 TD (\023\030\024\020\027\024\f\021\017\004\036\f\022\017\b \235\026\022\021\024\ \030\024\r \023\036\030\036\007 \027\026\004\026\035\024\n \035\036\004\036\ \027\017\016 )Tj 0.319 Tw 0 -1.218 TD (\206\224\207\215, \030\026\030\026\002\024\021\022\017 \n\036\021\024\007\ \017\022 \024\006\036\027\022\017 \220\235\235\036\022\021\017\r\027\024\ \f\021\017 )Tj 0 Tw 0 -1.218 TD (\017)Tj /Span<>> BDC ( )Tj EMC (\002\036\024\023\026\f\027\024\f\021\017 \021\036\030\026\023\017\017.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\205)10(\210\036\033 \035\030\032\204\033)30(\021)42(\032)-21(\211\033\237)]TJ 57.136 0 Td (REVIEW)Tj -57.136 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 23, \023\0222, 202)69(4)]TJ 42.99 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 23, \023\0222, 202)69(4)]TJ /T1_5 1 Tf 25 0 0 25 20.9152 56.0378 Tm (174)Tj ET endstream endobj 542 0 obj [548 0 R] endobj 543 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\021\017)-10(\026)-19.9(\002\016\b\206\004\016 \b\005 \026)11.1(\t\235\016\225\005\200 \005\004\232\b\005\017\r\005\024\016\213\025\024 \ \f\022\004\016\r)-9.9(\026)11(\025\200\221\t\t \f\235\t\024\200 \002\022\225\016\255\005\t\004\026)11(\025\f )]TJ 0 -1 TD [(\r\022\f\025\r\225\016\b\005\026)11(\t\b\206\004\007\024\005 \220\016\213\025\b\t\f\016\004\005\200\024\005 \ \017\005\203\t\020\004\005\017\016? $\025\213\220\025\235 \b\005\026)11(\t\235\016\026)-20(\002\235\007$)]TJ 41.079 1 Td [(Is infliximab th)11(er)21(apy curr)31(ently r)31(ele)11(v)10(ant in patients )]TJ 2.1 -1 Td [(with inflammator)-30.9(y bow)11(el diseases? $r)31(e)11(vie)11(w$)]TJ ET 0 0 0 1 K 1 j 1 J [0 2.997]0 d /GS1 gs q 1 0 0 1 46.0167 401.4103 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 43.0197 401.4103 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q [0 2.997]0 d q 1 0 0 1 46.0167 364.2025 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 43.0197 364.2025 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q [0 2.997]0 d q 1 0 0 1 46.0167 106.7176 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 43.0197 106.7176 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q [0 2.997]0 d q 1 0 0 1 46.0167 79.1097 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 43.0197 79.1097 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q BT 0 0 0 1 k /T1_1 1 Tf 10 0 0 10 42.5197 724.8299 Tm (https://doi.org/10.33878/2073-7556-2024-23-2-173-183)Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 0.023 Tw 19 0 0 19 63.9855 695.3259 Tm [(\021\017)-10(\026)-20(\002\016\b\206\004\016 \b\005 \026)11(\t\235\016\225\005\200 \005\004\232\b\005\017\r\005\024\016\213\025\024 \ \f\022)-23.3(\004\016\r)-10(\026)11(\025\200\221\t\t )]TJ -0.538 -1.105 Td [(\f\235\t\024\200 \002\022)-23.2(\225\016\255\005\t\004\026)11(\025\f \r\022)-23.3(\f\025\r\225\016\b\005\026)11.1(\t\b\206\004\007\024\005 \220\016\213\025\b\t\f\016\004\005\200\024\005 \ )]TJ 4.566 -1.105 Td [(\017\005\203\t\020\004\005\017\016? $\025\213\220\025\235 \b\005\026)11(\t\235\016\026)-19.9(\002\235\007$)]TJ 0 0 0 1 k /GS1 gs 14 0 0 14 42.5197 628.822 Tm [(\021)-21(\b\t\017\r\016\004\207\235\025\f\022)-23.2(\032.\035., \240\007\017)10.1(\025\f\016\022)-23.3(\205.\021)-31(.)]TJ 10 0 0 10 42.5197 611.1527 Tm [(\202\031\205)42(\211 \253\217\215\030\231 \017)10(\025\b\025\225\235\025\017)-9.9(\026)11(\025\b\025\006\005\005 \005\024\t\004\005 \021)-30.9(.\217.\022)-23.3(\033\007\226\005\001\273 \215\005\004\220\207\235\016\f\016 \033\025\r\r\ \005\005 $\002\b.\022)-23.2(\013\016\b\200\024\016 \021)-20.9(\207\005\b\200, \207.\022)-23.3(2, \006)62.1(.\022)-23.3(\215\025\r\017\f\016, )]TJ 0 -1.2 TD [(1)125(23)58(423, \033\025\r\r\005\200$)]TJ /T1_1 1 Tf 0.133 Tw 9 0 0 9 90.7087 580.6488 Tm (\206\206\220\007\220\002\200\220: \036)Tj /Span<>> BDC ( )Tj EMC (\020\037\024\035\034\030\202\016\016 \036\033\016\003\030 \036)Tj /Span<>> BDC ( )Tj EMC (\027\016\201\016\020\022\022 \024\033\016\004\020\016\035\030\t\001\027\032\ \017\034\033\003 \036\034\024\f\037\027\022\035\016\027\215\020\032 \031\ \037\025\034\027\016\036\037\020\022\b \021\022\235\016\201\020\022\021\037\ )Tj -0.002 Tw 0 -1.111 TD ($\206\255\r$ \037\021\035\022\036\020\034 \022\024\f\034\027\215\031\023\ \026\035\024\030 \013\016\020\020\034-\022\020\t\016\020\016\033\020\032\ \016 \f\033\016\f\037\033\037\035\032 $\221\200\006\207$ \022)Tj /Span<>> BDC ( )Tj EMC (\035\037\033\013\016\035\020\032\016 \022\003\003\023\020\034\024\023\f\033\ \016\024\024\034\033\032 $\205\200\217$. )Tj 0.07 Tw T* [(\002\016\024\003\034\035\033\030 )0.6(\020\037)]TJ /Span<>> BDC ( )Tj EMC 5.716 0 Td [(\031\020\037\201\022\035\016\027\215\020\034\016 )0.7(\023\027\023\201\235\016\020\022\016 )0.5(\022\024\034\004\034\036 )0.6(\031\037\025\034\027\016\036\037\020\022\b, )0.7(\023\027\023\201\235\016\020\022\030 )0.5(\021\037\201\016\024\035\036\037 )0.5(\t\022\031\020\022 )0.5(\f\037\n\022\016\020\035\034\036 )0.5(\022)]TJ /Span<>> BDC ( )Tj EMC 37.635 0 Td (\024\020\022)Tj 0 Tw (-)Tj 0.129 Tw -43.35 -1.111 Td (\t\016\020\022\016 \022\033\023\033\013\022\201\016\024\021\034\b \037\021\ \035\022\036\020\034\024\035\022, \036)Tj /Span<>> BDC ( )Tj EMC (\004\034\027\013\034\024\033\034\201\020\034\b \f\016\033\024\f\016\021\035\ \022\036\016 \f\034\027\020\034\n\016\020\020\034\b \021\027\022\020\022\ \021\034-\022\020\024\035\033\023\003\016\020\035\037\027\215\020\034\b \ )Tj 0.023 Tw T* (\033\016\003\022\024\024\022\022 \020\016\033\016\004\021\034 \004\034\024\ \035\022\013\020\023\035\215 \020\016 \023\004\037\016\035\024\030, \022\ \027\022 \024)Tj /Span<>> BDC ( )Tj EMC (\035\016\201\016\020\022\016\003 \036\033\016\003\016\020\022 \034\035\036\ \016\035 \035\016\033\030\016\035\024\030.)Tj 0.05 Tw 0 -1.111 TD (\214\220\222\225: \024\022\024\035\016\003\037\035\022\031\037\n\022\030\ \004\037\020\020\032 \034\025 \204\017\017\016\021\035\022\036\020\034\ \024\035\022 \022)Tj /Span<>> BDC ( )Tj EMC (\025\016\031\034\f\037\024\020\034\024\035\022 \035\016\033\037\f\022\022\ \206\255\r \022\020\017\027\022\021\024\022\003\037\025\034\003, \037)Tj /Span<>> BDC ( )Tj EMC (\035\037\021\t\016 )Tj 0.248 Tw 0 -1.111 TD (\003\016\035\034\004\037\003 \033\037\020\020\016\b \022)Tj /Span<>> BDC ( )Tj EMC (\f\034\031\004\020\016\b \034\n\016\020\021\022 \204\017\017\016\021\035\ \022\036\020\034\024\035\022; \f\034\021\037\031\037\020\022\030\003, \036\ \022\004\037\003 \022)Tj /Span<>> BDC ( )Tj EMC (\034\024\034\025\016\020\020\034\024\035\030\003 \034\f\035\022\003\022\031\ \037\n\022\022 )Tj 0 Tw T* (\035\016\033\037\f\022\022.)Tj -0.054 Tw T* (\206\230\206\216\007\230: \020\016\024\003\034\035\033\030 \020\037)Tj /Span<>> BDC ( )Tj EMC (\f\034\030\036\027\016\020\022\016 \024\033\037\036\020\022\035\016\027\215\ \020\034 \025\034\027\215\235\034\013\034 \021\034\027\022\201\016\024\035\ \036\037 \020\034\036\032 \221\200\006\207 \022)Tj /Span<>> BDC ( )Tj EMC (\205\200\217, \034\024\035\037\016\035\024\030 \f\033\034\025\027\016\003\ \037 )Tj 0.023 Tw T* (\020\016\204\017\017\016\021\035\022\036\020\034\024\035\022 \022\027\022\ \f\034\035\016\033\022 \034\035\036\016\035\037. \002\037)Tj /Span<>> BDC ( )Tj EMC (\020\037\235 \036\031\013\027\030\004, \033\016\235\016\020\022\016\003 \ \204\035\034\b \f\033\034\025\027\016\003\032 \003\034\t\016\035 \025\032\ \035\215 \f\016\033\024\034\020\022\017\022)Tj 0 Tw (-)Tj 0.08 Tw T* (\021\037\n\022\030 \020\037\031\020\037\201\016\020\022\030 \022)Tj /Span<>> BDC ( )Tj EMC (\033\016\t\022\003\034\036 \035\016\033\037\f\022\022 \221\200\006\207. \ \206)Tj /Span<>> BDC ( )Tj EMC (\020\037\024\035\034\030\202\016\016 \036\033\016\003\030 \016\024\035\215\ \020\016\003\037\027\034 \022\024\024\027\016\004\034\036\037\020\022\b\ , \f\034\024\036\030\202\016\020\020\032 )Tj -0.02 Tw 0 -1.111 TD (\021\037\021 \021\027\022\020\022\201\016\024\021\022\003, \035\037\021 \ \022)Tj /Span<>> BDC ( )Tj EMC (\027\037\025\034\033\037\035\034\033\020\032\003 \003\037\033\021\016\033\ \037\003, \022\003\016\026\202\022\003 \f\033\034\013\020\034\024\035\022\ \201\016\024\021\034\016 \031\020\037\201\016\020\022\016 \036)Tj /Span<>> BDC ( )Tj EMC (\036\016\004\016\020\022\022 \f\037\n\022\016\020\035\034\036 )Tj 0.069 Tw 0 -1.111 TD (\024)Tj /Span<>> BDC ( )Tj EMC (\206\255\r \f\033\022)Tj /Span<>> BDC ( )Tj EMC [(\035\016\033\037\f\022\022 \022\020\017\027\022\021\024\022\003\037\025\034\ \003. )0.6(\216\004\020\037\021\034 \204\035\022 )0.5(\022\024\024\027\016\004\034\036\037\020\022\030 )0.5(\020\016 \036\037\027\022\004\022\033\034\036\037\020\032 \004\027\030 \033\ \034\024\024\022\b\024\021\034\b )0.5(\f\034\f\023\027\030\n\022\022 )]TJ 0.023 Tw T* (\f\037\n\022\016\020\035\034\036. \205\033\016\025\023\016\035\024\030 \f\ \033\034\036\016\004\016\020\022\016 \003\020\034\013\034\n\016\020\035\033\ \034\036\032 \022\024\024\027\016\004\034\036\037\020\022\b \020\037)Tj /Span<>> BDC ( )Tj EMC (\033\034\024\024\022\b\024\021\034\b \f\034\f\023\027\030\n\022\022 \f\037\ \n\022\016\020\035\034\036.)Tj /T1_2 1 Tf 0.01 Tc 0.015 Tw 8 0 0 8 42.5596 435.3795 Tm [(\037\033\005\004\030\025\003\030)5( \026\033\036\025\021:)]TJ /T1_1 1 Tf 0 Tc 0.02 Tw 8.49 0 Td ( \036\034\024\f\037\027\022\035\016\027\215\020\032\016 \031\037\025\034\ \027\016\036\037\020\022\030 \021\022\235\016\201\020\022\021\037, \206\255\ \r, \030\031\036\016\020\020\032\b \021\034\027\022\035, \243\r, \025\034\ \027\016\031\020\215 \r\033\034\020\037, \006\r, \013\016\020\020\034-\022\ \020\t\016\020\016\033\020\037\030 \025\022\034\027\034\013\022)Tj 0 Tw (-)Tj 0.023 Tw -8.495 -1.2 Td (\201\016\024\021\037\030 \035\016\033\037\f\022\030, \221\200\006\207)Tj /T1_2 1 Tf 0.01 Tc 0.018 Tw 0.005 -1.909 Td [(\037\036\035\034\033\032\037\031)5( \032\035\031\030\027\030\026\036\025:)]TJ /T1_1 1 Tf 0 Tc 0.023 Tw 10.401 0 Td ( \037\036\035\034\033\032 \031\037\030\036\027\030\026\035 \034\025 \034\ \035\024\023\035\024\035\036\022\022 \021\034\020\017\027\022\021\035\037\ \022\020\035\016\033\016\024\034\036)Tj /T1_2 1 Tf 0.036 Tc 0.344 Tw -10.401 -2.617 Td [(\024\033\023)5.2( \022\032\031\032\027\036\025\021\035\032\023:)]TJ /T1_3 1 Tf 0.026 Tc 0.349 Tw 9.556 0 Td ( \202\035\036\022\f\026\027\007\030\024\r)Tj /Span<>> BDC ( )Tj EMC (\231.\214., \200\t\022\024\r\026)Tj /Span<>> BDC ( )Tj EMC (\207.\202. \202\022\021\031\026\035\034\027\026 \035\017 \021\036\030\026\ \023\017\016 \017\027\235\035\017\022\f\017\n\026\002\024\n \r)Tj /Span<>> BDC ( )Tj EMC (\027\026\f\021\024\016\013\036\036 \r\030\036\n\016 \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017)Tj 0 Tc 0 Tw (-)Tj 0.023 Tc 0.221 Tw -9.561 -1.2 Td (\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\r\024\f\023\026\035\017\021\036\035\034\027\t\n\017 \026\002\024\035\036\ \r\026\027\017\016\n\017 \022\017\001\036\004\027\017\022\026? $\024\002\ \024\030 \035\017\021\036\030\026\021\031\030\t$. )Tj /T1_1 1 Tf -0.023 Tw (\r\034\027\034\f\033\034\021\035\034\027\034\013\022\030.)Tj /T1_3 1 Tf 0.221 Tw ( 2024; \021.)Tj /Span<>> BDC ( )Tj EMC (23, \223)Tj /Span<>> BDC ( )Tj EMC (2, \f.)Tj /Span<>> BDC ( )Tj EMC [(173\226183.)23( )]TJ -0.023 Tw 0 -1.2 TD (https://doi.org/10.33878/2073-7556-2024-23-2-173-183)Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 0 Tc 0.023 Tw 18 0 0 18 93.4913 338.0332 Tm [(Is infliximab th)11.1(er)21(apy curr)31(ently r)31(ele)11(v)10(ant in patients )]TJ 1.073 -1.167 Td [(with inflammator)-31(y bow)11(el diseases? $r)31(e)11(vie)11(w$)]TJ 0 0 0 1 k /GS1 gs 14 0 0 14 42.5197 292.5292 Tm [(Timofey\022)-23.2(L.\022)-23.3(Ale)21(x)11(andr)20(ov)21(, Bella\022)-23.2(A)-31(.\022)-23.3(V)30(yk)11.1(ov)9.9(a)]TJ 10 0 0 10 42.5197 274.86 Tm [(R)20(y)21(zhikh National Medical Resear)31(ch Center of Colopr)20.1(octology $Saly)21(ama Adily)21.1(a\022)-23.3(st., 2, Moscow)22(, 1)125(23)58(423, Russia$)]TJ /T1_1 1 Tf 0.004 Tw 9 0 0 9 90.7087 256.356 Tm [(INTR)19(ODUCTION: )0.6(g)12(enetically )0.6(engineered )0.5(biological )0.6(drugs )0.5($GIBD$ )0.6(used )0.5(in )0.5(the )0.5(treatment of moderate )0.5(to )0.5(sev)13(ere )0.5(inf)-22(lam)]TJ 0 Tw (-)Tj 0.021 Tw 0 -1.111 TD [(mator)-42.9(y bow)12(el diseases $IBD$ cur)-16(rently)32(. Despite a signif)-43(icant im)16(p)46(rov)13(ement in disease outcomes, im)16(p)46(rov)13(ement in the )]TJ 0.091 Tw T* [(q)14(uality )0.5(of life )0.5(of patients and )0.5(a decrease )0.5(in surgical )0.5(activity)42.1(, in )0.5(the long )0.5(ter)-14(m, it )0.5(is of)-46(ten no)13(t possible to )0.5(achiev)13(e )]TJ 0.023 Tw T* [(full-f)-21.9(ledg)12(ed clinical and instrumental remission or the loose of response ov)13(er time.)]TJ -0.014 Tw 0 -1.111 TD [(OBJECTIVE: to systematize d)26(ata on the ef)-39.9(f)-43(icacy and safety of IBD inf)-21.9(liximab therap)12(y)42(, as w)12(ell as methods of early and )]TJ 0.023 Tw 0 -1.111 TD [(late ef)-39.9(f)-43(icacy assess)33.1(ment; indications, types and features of therap)12.1(y op)13(timization.)]TJ 0.006 Tw T* [(C)21(ON)22(CLUSIONS: despite the appearance of a relativ)13.1(ely larg)12(e number of ne)10(w GIBD and TIS, the p)46(roblem of inef)-40(f)-43(iciency )]TJ 0.026 Tw T* [(or loss of response remains. In our opinion, the solution to this p)46(roblem may be the personif)-43(ication of the appoint)]TJ 0 Tw (-)Tj 0.106 Tw T* [(ment and treatment regimens of GIBP)114(. Cur)-16(rently)42(, there are man)11(y studies dev)13(o)13(ted to bo)13(th clinical and laborator)-43(y )]TJ -0.018 Tw T* [(mark)17.1(ers of p)46(rognostic im)16(por)-39.9(tance in the manag)12(ement of patients with IBD dur)-37(ing inf)-22(liximab therap)12(y)32(. How)11.9(ev)12.9(er)61(, these )]TJ 0.038 Tw T* [(studies are no)13(t localized for the R)22(ussian patient population. Multicenter studies on the R)22(ussian patient population )]TJ 0.023 Tw 0 -1.111 TD [(are req)14.1(uired.)]TJ /T1_2 1 Tf 0.01 Tc -0.01 Tw 8 0 0 8 42.5596 131.0868 Tm [(KEYW)22(ORDS:)]TJ /T1_1 1 Tf 0 Tc 0.023 Tw 4.948 0 Td [( inf)-22(lammator)-42.9(y bow)12(el diseases, IBD, ulcerativ)13.1(e colitis, UC, Crohn)24(\241)37(s disease, CD, g)12(enetically engineered biological therap)12.1(y)42(, GIBP)]TJ /T1_2 1 Tf 0.01 Tc 0.018 Tw -4.948 -1.909 Td [(C)19(ONFL)-33(ICT)5( OF)5( INTE)25(REST)62(:)]TJ /T1_1 1 Tf 0 Tc 0.023 Tw 9.871 0 Td [( the authors declare no conf)-22(lict of interest)]TJ /T1_2 1 Tf 0.037 Tc -0.026 Tw -9.871 -2.617 Td [(F)3.2(O)-4.6(R)8.7( C)-17.4(I)-15.6(T)45.4(A)37.5(T)-24.5(I)-1.3(ON:)]TJ /T1_3 1 Tf 0.023 Tc -0.017 Tw 6.419 0 Td [( A)-11.7(l)-23.7(e)-33.1(x)-24.2(a)-7.6(n)-14.5(d)-10.4(r)-15.8(o)-10.3(v)]TJ /Span<>> BDC ( )Tj EMC [(T)52.5(.L)-29.4(.)-23.5(, V)-25.2(y)-21.9(k)-3.7(o)-10.3(v)-28.4(a)]TJ /Span<>> BDC ( )Tj EMC [(B)3.3(.)-23.9(A)-23(. I)-29.9(s i)-3.2(n)-13.5(f)-47.1(l)-16.7(i)-17.7(x)-41.4(i)-3.2(m)-8.3(a)-18.2(b t)-26(h)-15.1(e)-12.1(r)-30.8(a)-8.8(p)-19.6(y c)-12.1(u)-7.6(r)-40.5(r)-19.1(e)-11.5(n)-17.3(t)-27.1(l)-8.3(y r)-19.1(e)-18(l)-23.7(e)-15.8(v)-28.3(a)-7.7(n)-17.3(t i)-3.1(n p)-20.1(a)-18.1(t)-46.2(i)-11(e)-11.5(n)-17.3(t)-48.9(s w)-45.7(i)-15.8(t)-26.1(h i)-3.2(n)-13.5(f)-47.1(l)-37.8(a)-9.6(m)-6.2(m)-8.3(a)-18.2(t)-21.9(o)-11.8(r)-60.6(y b)-20.4(o)-8.4(w)-17.7(e)-18(l d)-15.7(i)-7.4(s)-22.9(e)-13(a)-26.6(s)-22.9(e)-22.8(s)7(?)23( )]TJ -0.016 Tc 0.016 Tw -6.424 -1.2 Td [($r)-58.1(e)-54.8(v)-90.8(i)-50(e)-51.5(w)-19.4($)-28.6(.)-39.3( )]TJ /T1_1 1 Tf 0.033 Tc -0.033 Tw 4.166 0 Td [(K)13.9(ol)3.6(op)2.4(r)3.1(o)3.4(k)-19.2(t)2.2(ol)3.6(o)-3.3(g)-13.2(i)6.7(a)5.8(.)]TJ /T1_3 1 Tf 0.013 Tc 0.034 Tw 7.019 0 Td [( 2)-18.9(0)-13.8(2)-1.2(4;2)-20.3(3)-4($)23.6(2)20.3($)4.6(:)10.9(1)14.2(7)-11.9(3)-22.1(\226)40.8(1)-12.4(8)-19.4(3)-3.2(.)-10.3( $)-10.9(i)-13.2(n)-10.3( R)-16.5(u)-31.9(s)-32.2(s)-25.5(.)33.2($.)-10.3( h)-27.2(t)-59.4(t)-39.4(p)-28.7(s)-17.9(:)-8.1(/)74.7(/)26.4(d)-21.1(o)-22.5(i)-10.2(.)-7.3(o)-21.8(r)-26.7(g)-32.8(/)1.2(1)4(0)-3.5(.)-15.5(3)-2.1(3)-25.9(8)-8.7(7)-5.4(8)-10(/)-2.1(2)-18.9(0)-0.7(7)-11.9(3)-23.3(-)31.2(7)0.7(5)-9.6(5)-18.9(6)-36.7(-2)-18.9(0)-13.8(2)-1.2(4)-38.5(-2)-20.3(3)-23.3(-2)2.1(-)45.2(1)14.2(7)-11.9(3)-23.3(-)45.1(1)-12.4(8)-19.4(3)]TJ ET 1 0.68 0 0.12 k /GS0 gs q 1 0 0 1 42.5197 589.1533 cm 0 0 m 0 0 l 0 -11.339 l 42.52 -11.339 l 42.52 0 l h f Q BT 0 0 0 0 k /T1_2 1 Tf 0 Tc 0 Tw 9 0 0 9 47.6607 580.226 Tm (\027\030\002\005\001\030)Tj ET 1 0.68 0 0.12 k q 1 0 0 1 42.5197 264.8604 cm 0 0 m 0 0 l 0 -11.339 l 42.52 -11.339 l 42.52 0 l h f Q BT 0 0 0 0 k /T1_2 1 Tf 9 0 0 9 45.2263 255.9331 Tm (ABSTRACT)Tj ET q 0 0 566.929 793.701 re W n BT 1 0.68 0 0.12 k /T1_4 1 Tf 0.01 Tc 0.018 Tw 14 0 0 14 42.5895 837.3533 Tm [(\004\210)42(\215\004\n)5( \b\006\r\207\n)43(\037)31(\r)-21(\013\n\233)]TJ /T1_0 1 Tf -0.01 Tw 0 -1.605 TD (REVIEW)Tj ET Q BT 1 0.68 0 0.12 k /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\205)10(\210\036\033 \035\030\032\204\033)30(\021)42(\032)-21(\211\033\237)]TJ 57.136 0 Td (REVIEW)Tj /T1_5 1 Tf 25 0 0 25 505.5395 56.0378 Tm (173)Tj ET q 0 g 0 G 0 j 0 J /Fm1 Do Q 0 0 0 0 k 368.504 725.67 59.155 11.338 re f /PlacedPDF /MC0 BDC q 369.135 736.808 m 368.896 736.808 368.703 736.616 368.703 736.376 c 368.703 736.376 l 368.703 726.285 l 368.703 726.045 368.896 725.853 369.135 725.853 c 369.135 725.853 l 427.035 725.853 l 427.273 725.853 427.469 726.045 427.469 726.285 c 427.469 726.285 l 427.469 736.376 l 427.469 736.616 427.273 736.808 427.035 736.808 c 427.035 736.808 l h W n q 0 g -0.0000005 -10.9560913 -10.9560913 0.0000005 398.0855785 736.8086309 cm BX /Sh0 sh EX Q Q q 368.504 725.67 59.155 11.337 re W n 0 0 0 0.84 k q 1 0 0 1 385.2169 732.4249 cm 0 0 m -0.025 0.1 -0.063 0.196 -0.112 0.287 c -0.157 0.374 -0.218 0.451 -0.292 0.515 c -0.37 0.582 -0.46 0.632 -0.558 0.664 c -0.669 0.701 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T)47(he st)15(a)15(te of oncol)30(o)-15.9(gical car)-24(e for )]TJ 0.211 Tw T* [(t)-13(he )0.5(popul)-16(a)15(t)-31.9(ion )0.5(of Russia )0.5(in )0.5(2022. M.: )0.6(P.A. )0.5(Her)-24(zen )0.5(M)-23.9(osco)-14(w )0.5(S)15(t)15(a)15(te )]TJ 0.018 Tw T* [(Medical )0.6(R)13(esear)-32(ch )0.5(Inst)-31.9(i)-24(tute)]TJ /Span<>> BDC ( )Tj EMC 11.084 0 Td [(\227 )0.6(br)-33(anch )0.5(of )0.6(t)-13(he )0.5(F)10(eder)-32.9(al )0.5(S)15(t)15.1(a)15(te )0.5(Budge)-12(t)15(ar)-23.9(y )]TJ 0.005 Tc 0.35 Tw -11.084 -1.25 Td [(Inst)-32.2(i)-24.1(tut)-32.1(ion \236NMIRC\237 of t)-13.1(he Ministr)-24.1(y of Heal)55.9(t)-13.1(h of t)-13.1(he Russian)5.1( )]TJ 0 Tc -0.009 Tw T* [(F)10(eder)-33(a)15(t)-31.9(ion. 2023; 254 \030. $in Russ.$. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.17709/2409-2231-2015-)Tj T* (2-3-118-123)Tj 0 0 0 1 k /GS1 gs 0.32 Tw T* (3.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Sa)10(wick)-16(i)]TJ /Span<>> BDC ( )Tj EMC [(T, Ruszko)-13.9(wsk)-17(a)]TJ /Span<>> BDC ( )Tj EMC (M, Danielewicz)Tj /Span<>> BDC ( )Tj EMC [(A, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. A R)13(ev)-16(iew of )]TJ -0.073 Tw -1.296 -1.25 Td [(Col)30(or)-24(ec)-15.9(t)15(al )0.5(Cancer )0.5(in )0.5(T)40(er)-16(ms )0.5(of )0.5(Epidemiol)30(o)-16(g)16(y, )0.5(R)-24(isk )0.5(F)20(a)-17(c)-16(t)17.1(or)-10(s, )0.5(Devel)30(opment, )]TJ 0.087 Tw T* [(Sym)10(pt)17(oms and Dia)-17(gnosis. )]TJ /T1_4 1 Tf (Cancers $Basel$.)Tj /T1_1 1 Tf [( 2021 Ap)25(r 22;13$9$:2025. )]TJ 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td [(10.3390/cancer)-9.9(s13092025)]TJ 0 0 0 1 k /GS1 gs 0.015 Tw -1.847 -1.25 Td (4.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(R)-10(a)10(wl)-16(a)]TJ /Span<>> BDC ( )Tj EMC 2.606 0 Td [(P, Sunk)-16.9(ar)-33(a)]TJ /Span<>> BDC ( )Tj EMC [(T, Bar)-9.9(souk)]TJ /Span<>> BDC ( )Tj EMC [(A. )0.5(Epidemiol)30(o)-16(g)16(y of )0.5(col)30(or)-24(ec)-16(t)15(al )0.5(cancer: )]TJ 0.25 Tw -3.902 -1.25 Td [(inc)-24(idence, )0.6(mor)-22(t)15(al)-31(i)-23.9(t)-10(y, )0.5(sur)-31.9(v)-16(i)-16(v)-15(al, )0.5(and )0.6(r)-37(isk )0.5(f)16(a)-17(c)-15.9(t)17(or)-10(s. )]TJ /T1_4 1 Tf 20.351 0 Td [(Pr)-16(z )0.6(Gastroenterol.)]TJ /T1_1 1 Tf 0 Tw ( )Tj 0.023 Tw -20.351 -1.25 Td [(2019;14$2$:89\226103. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.5114/pg.2018.81072)Tj 0 0 0 1 k /GS1 gs 0.336 Tw T* (5.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(K)25(eum)]TJ /Span<>> BDC ( )Tj EMC [(N, Giov)-14.9(annucc)-24(i)]TJ /Span<>> BDC ( )Tj EMC [(E. Gl)30(obal bur)-24(den of col)30(or)-24(ec)-16(t)15(al cancer: )]TJ 0.262 Tw -1.296 -1.25 Td [(emer)-32(ging tr)-24(ends, r)-36.9(isk f)16(a)-17(c)-16(t)17(or)-10(s and p)25(r)-24(event)-32(ion str)-33(a)15(tegies. )]TJ /T1_4 1 Tf [(N)18(at R)21(ev )]TJ 0.084 Tw T* (Gastroenterol Hepatol)Tj /T1_1 1 Tf [(. 2019;16$12$:713\226732. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1038/s41575-)Tj T* (019-0189-8)Tj 0 0 0 1 k /GS1 gs 0.216 Tw T* (6.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (\217\t\002\026\022\024\r)Tj /Span<>> BDC ( )Tj EMC 3.979 0 Td [(\213.\206., )0.5(\203\026\235\036\007\024\r)]TJ /Span<>> BDC ( )Tj EMC 6.695 0 Td [(\224.\210., )0.5(\216\024\n\016\022\024\r)]TJ /Span<>> BDC ( )Tj EMC 6.315 0 Td [(\213.\202., )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 3.229 0 Td [(\f\024\026\r\021. )0.5(\204\036\021\024\007\t )]TJ 0.01 Tc 0.386 Tw -21.514 -1.25 Td (\022\024\027\f\036\030\r\026\021\017\r\027\024\020\024 \035\036\004\036\027\ \017\016 \f\017\027\007\030\024\n\026 \027\017\022\024\005 \023\036\030\ \036\007\027\036\005 \030\036\036\022)Tj 0 Tc 0 Tw (-)Tj 0.016 Tc 0.595 Tw T* (\006\017\017 $\024\002\024\030 \035\017\021\036\030\026\021\031\030\t$\ . )Tj /T1_4 1 Tf -0.016 Tw (\r\034\027\034\f\033\034\021\035\034\027\034\013\022\030)Tj /T1_1 1 Tf 0.595 Tw [(. 2018;3:79\22683.)16( )]TJ 0.021 Tc -0.021 Tw T* [(d)-16.2(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 2.694 0 Td (10.33878/2073-7556-2018-0-3-79-83)Tj 0 0 0 1 k /GS1 gs 0.764 Tw [( / R)-20.1(ybakov)]TJ /Span<>> BDC ( )Tj EMC [(E.G.,)21( )]TJ 0 Tc 0.327 Tw -2.694 -1.25 Td [(Nafed)17(zov)]TJ /Span<>> BDC ( )Tj EMC 4.239 0 Td [(I.O., )0.5(Khomy)22(akov)]TJ /Span<>> BDC ( )Tj EMC 7.361 0 Td [(E.A., )0.5(e)-12(t)]TJ /Span<>> BDC ( )Tj EMC 3.764 0 Td [(al. )0.5(Me)-12(t)-13(hod )0.5(Apost)-32(ille )0.6(conser)]TJ 0 Tw 11.921 0 Td (-)Tj 0.01 Tc 0.386 Tw -27.286 -1.25 Td [(v)-15.3(a)14.6(t)-32.4(i)-16.3(ve tr)-24.4(ea)14.6(tments l)29.7(o)-14.4(w per)-24.3(edna)14.6(y r)-24.3(esec)-16.3(t)-32.4(ion syndr)-32.3(ome $r)-24.3(ev)-16.3(iew$.)10( )]TJ /T1_4 1 Tf 0.003 Tc -0.003 Tw T* [(K)18(olop)45.9(roktologia)]TJ /T1_1 1 Tf 0.35 Tw [(. )0.5(2018;3:79\22683. )0.5($in )0.5(Russ.$. )0.5(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs -0.003 Tw 21.007 0 Td (10.33878/2073-)Tj 0 Tc 0 Tw -21.007 -1.25 Td (7556-2018-0-3-79-83)Tj 0 0 0 1 k /GS1 gs 0.084 Tw T* (7.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(P)40(appou)]TJ /Span<>> BDC ( )Tj EMC [(EP, T)40(em)10(ple)]TJ /Span<>> BDC ( )Tj EMC [(LK, P)40(a)15(t)-32(il)]TJ /Span<>> BDC ( )Tj EMC [(S, e)-11.9(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Q)-16(ual)-31(i)-24(t)-10(y of l)-31(ife and func)-15.9(t)-32(ion )]TJ 0.229 Tw -1.296 -1.25 Td [(af)-28(ter r)-24(ec)-16(t)15.1(al cancer sur)-31.9(ger)-24(y wi)-24(t)-13(h and wi)-24(t)-13(hout sphinc)-15.9(ter p)25.1(r)-24(eser)-32(v)-15(a)]TJ 0 Tw (-)Tj T* [(t)-32(ion. )]TJ /T1_4 1 Tf 0.051 Tw 2.262 0 Td [(F)27(ront Oncol.)]TJ /T1_1 1 Tf [( 2022 O)-16(c)-16(t 21;12:944843. PMID: 36353560; PMCID: )]TJ 0.023 Tw -2.262 -1.25 Td [(PMC9639454. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.3389/fonc.2022.944843)Tj 0 0 0 1 k /GS1 gs 0.062 Tw T* (8.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(L)35(ee)]TJ /Span<>> BDC ( )Tj EMC (CM, Huh)Tj /Span<>> BDC ( )Tj EMC [(JW, P)40(ar)-24(k)]TJ /Span<>> BDC ( )Tj EMC [(Y)40.9(A, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. R)-24(isk f)16(a)-16.9(c)-16(t)17(or)-10(s of per)-16(manent st)17(omas )]TJ 0.277 Tw -1.296 -1.25 Td [(in )0.5(p)32(a)15(t)-32(ients )0.6(wi)-24(t)-13(h )0.6(r)-24(ec)-16(t)15(al )0.6(cancer )0.5(af)-28(ter )0.6(l)30(o)-14(w )0.5(anter)-37(ior )0.6(r)-24(esec)-16(t)-32(ion )0.6(wi)-24(t)-13(h )]TJ 0.04 Tw T* [(tem)10(por)-33(ar)-23.9(y st)17.1(omas. )]TJ /T1_4 1 Tf [(Y)48(onsei Med)]TJ /Span<>> BDC ( )Tj EMC (J.)Tj /T1_1 1 Tf [( 2015;56$2$:447 453. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.3349/)Tj T* (ymj.2015.56.2.447)Tj 0 0 0 1 k /GS1 gs 0.295 Tw T* (9.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(P)30(eng)]TJ /Span<>> BDC ( )Tj EMC [(B, L)35(u)]TJ /Span<>> BDC ( )Tj EMC [(J, W)16(u)]TJ /Span<>> BDC ( )Tj EMC [(Z, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Inter)-10(sphinc)-15.9(ter)-37(ic R)13(esec)-16(t)-32(ion V)30(er)-9.9(sus )]TJ 0.023 Tc 0.834 Tw -1.296 -1.25 Td [(A)-14.1(bd)-16.2(ominoper)-37.2(ineal R)12.8(esec)-16.1(t)-32.2(ion for L)34.8(o)-14.1(w R)12.8(ec)-16.1(t)14.8(al Cancer: A)23( )]TJ 0.029 Tc -0.029 Tw T* [(Me)-12(t)15.1(a-Anal)35.1(y)-12.9(sis. )]TJ /T1_4 1 Tf 1.037 Tw 7.573 0 Td [(Surgical Innov)16.1(ation)]TJ /T1_1 1 Tf [(. 2020;27$4$:392\226401.)29( )]TJ 0 Tc 0 Tw -7.573 -1.25 Td [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1177/1553350620918414)Tj 0 0 0 1 k /GS1 gs 0.055 Tw -1.847 -1.25 Td (10.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Cor)-15(nish)]TJ /Span<>> BDC ( )Tj EMC [(J)15(A, T)35(ilne)-10.9(y)]TJ /Span<>> BDC ( )Tj EMC [(HS, Her)-37(io)17(t)]TJ /Span<>> BDC ( )Tj EMC [(A)16(G, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. A me)-12(t)15(a\226anal)35(y)-13(sis of qual)]TJ 0 Tw (-)Tj 0.113 Tw -1.796 -1.25 Td [(i)-24(t)-10(y of l)-31(ife for abd)-16(ominoper)-37(ineal e)-18(x)-12.9(c)-24(ision of r)-24(ec)-16(tum ver)-9.9(sus anter)-37(ior )]TJ 0.088 Tw T* [(r)-24(esec)-15.9(t)-32(ion for r)-24(ec)-16(t)15.1(al cancer. )]TJ /T1_4 1 Tf (Ann Surg Oncol)Tj /T1_1 1 Tf (. 2007;14$7$:2056 2068. )Tj 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1245/s10434-007-9402-z)Tj 0 0 0 1 k /GS1 gs 0.191 Tw -1.847 -1.25 Td (11.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(L)-32(iber)-33(a)15.1(t)-32(i)]TJ /Span<>> BDC ( )Tj EMC [(A, Al)56.1(tman)]TJ /Span<>> BDC ( )Tj EMC [(D, T)40(e)-12(tzl)-15.9(af)-56(f)]TJ /Span<>> BDC ( )Tj EMC [(J, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. T)47(he PRISMA st)15(a)15(tement )]TJ 0.082 Tw -1.796 -1.25 Td [(for r)-24(epor)-21.9(t)-32(ing sy)-13(stema)15.1(t)-32(ic r)-24(ev)-16(iews and me)-11.9(t)15(a\226anal)35(y)-13(ses of studies t)-13(ha)15(t )]TJ -0.011 Tw 29.055 61.25 Td [(ev)-15(al)35(ua)15(te heal)56(t)-12.9(hcar)-24(e inter)-32(vent)-32(ions: e)-18(xpl)-15.9(ana)15(t)-32(ion and el)-16(abor)-32.9(a)15(t)-32(ion. )]TJ /T1_4 1 Tf 0 Tw (BMJ )Tj T* [([Inter)-13.9(net].)]TJ /T1_1 1 Tf 0.023 Tw [( 2009;339:2700\226b2700. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1136/bmj.b2700)Tj 0 0 0 1 k /GS1 gs 0.066 Tw T* (12.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(S)-24(chmid)17(t)]TJ /Span<>> BDC ( )Tj EMC (C, Bestmann)Tj /Span<>> BDC ( )Tj EMC (B, K\374chler)Tj /Span<>> BDC ( )Tj EMC [(T, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. P)35(r)-32(ospec)-15.9(t)-32(i)-16(ve ev)-15(al)35(ua)15(t)-32(ion )]TJ 0.288 Tw -1.796 -1.25 Td [(of qual)-31(i)-23.9(t)-10(y of l)-31(ife of p)32(a)15(t)-32(ients r)-23.9(ecei)-16(v)-16(ing ei)-24(t)-12.9(her abd)-16(ominoper)-37(ineal )]TJ 0.116 Tw T* [(r)-24(esec)-15.9(t)-32(ion or sphinc)-16(ter\226p)25(r)-24(eser)-32(v)-15.9(ing p)25(r)-32(o)-16(cedur)-24(e for r)-23.9(ec)-16(t)15(al cancer. )]TJ /T1_4 1 Tf 0 Tw (Ann )Tj 0.023 Tw T* (Surg Oncol)Tj /T1_1 1 Tf [(. 2005;12$2$:117 123. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw [(10.1245/A)35(SO.2005.12.036)]TJ 0 0 0 1 k /GS1 gs 0.131 Tw T* (13.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(F)10(edder)-15(n)]TJ /Span<>> BDC ( )Tj EMC [(ML, Emmer)-22(tsen)]TJ /Span<>> BDC ( )Tj EMC [(K)20.1(J, L)-31.9(aur)-24(ber)-32(g)]TJ /Span<>> BDC ( )Tj EMC [(S. Q)-16(ual)-31(i)-24(t)-10(y of l)-31(ife wi)-23.9(t)-13(h or )]TJ 0.319 Tw -1.796 -1.25 Td [(wi)-24(t)-12.9(hout sphinc)-15.9(ter p)25(r)-24(eser)-31.9(v)-15(a)15(t)-32(ion for r)-23.9(ec)-16(t)15(al cancer. )]TJ /T1_4 1 Tf (Colorectal Dis)Tj /T1_1 1 Tf 0 Tw (. )Tj 0.023 Tw T* [(2019;21$9$:1051 1057. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1111/codi.14684)Tj 0 0 0 1 k /GS1 gs 0.056 Tw T* (14.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(K)-16(asp)32(ar)-23.9(ek)]TJ /Span<>> BDC ( )Tj EMC (MS, Hassan)Tj /Span<>> BDC ( )Tj EMC (I, Cima)Tj /Span<>> BDC ( )Tj EMC [(RR, e)-11.9(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Q)-16(ual)-30.9(i)-24(t)-10(y of l)-31(ife af)-28(ter col)30(o)]TJ 0 Tw (-)Tj 0.157 Tw -1.796 -1.25 Td [(anal anast)17.1(omosis and abd)-16(ominoper)-37(ineal r)-24(esec)-16(t)-32(ion )0.5(for dist)15(al r)-23.9(ec)-16(t)15(al )]TJ 0.26 Tw T* [(cancer)-10(s: sphinc)-16(ter p)25(r)-24(eser)-32(v)-15(a)15.1(t)-32(ion vs qual)-31(i)-24(t)-10(y of l)-31(ife. )]TJ /T1_4 1 Tf (Colorectal Dis.)Tj /T1_1 1 Tf 0 Tw ( )Tj 0.023 Tw T* [(2011;13$8$:872\226877. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1111/j.1463-1318.2010.02347.x)Tj 0 0 0 1 k /GS1 gs 0.051 Tw T* (15.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Mr)-33(ak)]TJ /Span<>> BDC ( )Tj EMC [(K, Ja)-17(godi)-24(tsch)]TJ /Span<>> BDC ( )Tj EMC [(M, Eber)-29.9(l)]TJ /Span<>> BDC ( )Tj EMC [(T, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. L)35(ong-ter)-15.9(m qual)-31(i)-23.9(t)-10(y of l)-31(ife in )]TJ -0.016 Tw -1.796 -1.25 Td [(pouch p)32(a)15(t)-32(ients com)10(p)32(ar)-24(ed wi)-23.9(t)-13(h st)17.1(oma p)32(a)15(t)-32(ients foll)30(o)-13.9(wing r)-24(ec)-16(t)15.1(al cancer )]TJ 0 Tw T* [(sur)-32(ger)-23.9(y. )]TJ /T1_4 1 Tf 0.039 Tw 3.573 0 Td (Colorectal Dis.)Tj /T1_1 1 Tf [( 2011;13$12$:e403 410. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1111/j.1463-)Tj -3.573 -1.25 Td (1318.2011.02740.x)Tj 0 0 0 1 k /GS1 gs 0.114 Tw T* (16.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Gur)-23.9(en)]TJ /Span<>> BDC ( )Tj EMC [(MG, Er)-36.9(ik)-10(sen)]TJ /Span<>> BDC ( )Tj EMC [(MT, W)-16(i)-16(ig)]TJ /Span<>> BDC ( )Tj EMC [(JN, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. N)-14(or)-38(wegian R)13(ec)-16(t)15.1(al Cancer )]TJ 0.225 Tw -1.796 -1.25 Td [(G)20(r)-32(oup. Q)-16(ual)-31(i)-23.9(t)-10(y of l)-31(ife and func)-16(t)-32(ional outcome foll)30(o)-14(wing anter)-37(ior )]TJ 0.145 Tw T* [(or abd)-16(ominoper)-36.9(ineal r)-24(esec)-16(t)-31.9(ion for r)-24(ec)-16(t)15(al cancer. )]TJ /T1_4 1 Tf (Eur J Surg Oncol.)Tj /T1_1 1 Tf 0 Tw ( )Tj 0.023 Tw T* [(2005;31$7$:735\226742. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1016/j.ejso.2005.05.004)Tj 0 0 0 1 k /GS1 gs 0.147 Tw T* (17.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(N\344sv)-15(all)]TJ /Span<>> BDC ( )Tj EMC [(P, Dahlstr)-33(and)]TJ /Span<>> BDC ( )Tj EMC [(U, L\366wenmar)-23.9(k)]TJ /Span<>> BDC ( )Tj EMC [(T, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Q)-16(ual)-31(i)-24(t)-10(y of l)-30.9(ife in )]TJ 0.137 Tw -1.796 -1.25 Td [(p)32(a)15(t)-32(ients wi)-24(t)-13(h a per)-15.9(manent st)17(oma af)-28(ter r)-24(ec)-16(t)15(al cancer sur)-32(ger)-23.9(y. )]TJ /T1_4 1 Tf 0 Tw (Qual )Tj 0.023 Tw T* [(Life R)21.1(es.)]TJ /T1_1 1 Tf [( 2017;26$1$:55\22664. d)-15.9(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1007/s11136-016-1367-6)Tj 0 0 0 1 k /GS1 gs 0.204 Tw T* (18.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(K)25(onanz)]TJ /Span<>> BDC ( )Tj EMC [(J, Her)-23.9(r)-30(le)]TJ /Span<>> BDC ( )Tj EMC [(F, W)22(eiss)]TJ /Span<>> BDC ( )Tj EMC [(C, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. 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[(\032\017\027\017 )0.6($)]TJ /T1_1 1 Tf 0 Tw (p)Tj /T1_0 1 Tf 0.043 Tw /Span<>> BDC ( )Tj EMC 4.031 0 Td (>)Tj /Span<>> BDC ( )Tj EMC 0.775 0 Td [(0,05$. )0.5(\210\007\027\026\022\024, )0.5(\027\036\f\n\024\021\030\016 )0.5(\027\026)]TJ /Span<>> BDC ( )Tj EMC 11.438 0 Td (\f\021\026\021\017\f\021\017\004\036\f\022\017 )Tj 0.213 Tw -16.244 -1.218 Td (\027\026\004\017\n\t\036 \030\026\035\017\004\017\016 \r)Tj /Span<>> BDC ( )Tj EMC (\235\017\017\004\036\f\022\024\n \235\031\027\022\006\017\024\027\017\030\ \024\r\026)Tj 0 Tw (-)Tj 0.033 Tw 0 -1.218 TD (\027\017\017 $\030\026\027\024\f\021\034 \f\030\036\007\027\017\b \247\ 4,67, 95% \212\224 \2479,10)Tj /Span<>> BDC ( )Tj EMC (\227 \2470,23; )Tj /T1_1 1 Tf 0 Tw 0 -1.218 TD (p)Tj /T1_0 1 Tf 0.135 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,004$, \f\036\022\f\031\026\035\034\027\024\005 \235\031\027\022\006\017\ \017 $\030\026\027\024\f\021\034 \f\030\036\007\027\017\b )Tj 0.208 Tw 0 -1.218 TD (\2472,73, 95% \212\224 \2474,93)Tj /Span<>> BDC ( )Tj EMC (\227 \2470,64; )Tj /T1_1 1 Tf 0 Tw (p)Tj /T1_0 1 Tf 0.208 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,001$, \220\n\024\006\017\024)Tj 0 Tw (-)Tj 0.125 Tw T* (\027\026\035\034\027\024\n $\030\026\027\024\f\021\034 \f\030\036\007\027\ \017\b 3,57, 95% \212\224 1,41\2265,73; )Tj /T1_1 1 Tf 0 Tw T* (p)Tj /T1_0 1 Tf -0.019 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,001$ \017)Tj /Span<>> BDC ( )Tj EMC (\022\024\020\027\017\021\017\r\027\024\n $\030\026\027\024\f\021\034 \f\ \030\036\007\027\017\b 3,57, 95% )Tj -0.018 Tw T* (\212\224 \2471,41\2265,73; )Tj /T1_1 1 Tf 0 Tw (p)Tj /T1_0 1 Tf -0.018 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,001$ \f\021\026\021\031\f\036, \026\r\021\024\030\t \024\021\n\036\021\ \017\035\017 \017\b )Tj 0.021 Tw T* (\027\036\r\t\030\026\032\036\027\027\024\f\021\034 \023\024)Tj /Span<>> BDC ( )Tj EMC (\031\022\026\026\027\027\t\n \023\030\017\027\026\022\026\n \017)Tj /Span<>> BDC ( )Tj EMC (\r\t\027\036\f\035\017 )Tj -0.043 Tw T* [(\026\022\035\033\004\036\027\017\036 )0.6(\024)]TJ /Span<>> BDC ( )Tj EMC 5.813 0 Td [(\f\024\023\024\f\021\026\r\017\n\024\n )0.5(\022\026\004\036\f\021\r\036 )0.6(\032\017\027\017 )0.5(\017\f\f\035\036\007\031)]TJ 0 Tw (-)Tj -5.813 -1.218 Td (\036\n\t\b \020\030\031\023\023 \023\026\006\017\036\027\021\024\r.)Tj 0.066 Tw T* (\217\026\r\027\t\n \024\002\030\026\024\n, \023\030\024\r\036\007\036\027\ \027\t\005 \r)Tj /Span<>> BDC ( )Tj EMC (2015 \020\024\007\031 \n\036\021\026\026\027\026)Tj 0 Tw (-)Tj 0.186 Tw T* [(\035\017 )0.5([25], \r\022\035\033\004\017\r\001\017\005 )0.5(13 \017\f\f\035\036\007\024\r\026\027\017\005 )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC (\031\004\026\f\021\017\036\n )Tj 0.126 Tw T* (1805 \023\026\006\017\036\027\021\024\r, \023\024\022\026\026\035, \004\ \021\024 \022\026\004\036\f\021\r\024 \032\017\027\017 \023\026\006\017\ )Tj 0 Tw (-)Tj 0.191 Tw T* [(\036\027\021\024\r, )0.5(\023\036\030\036\027\036\f\001\017\b )0.6(\024\023\036\030\026\006\017\033 )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC 13.766 0 Td [(\023\024\f\021\024\016\027\027\024\005 )0.6(\f\021\024\n\024\005, )]TJ 0.173 Tw -13.766 -1.218 Td (\002\t\035\024 \f\030\026\r\027\017\n\024 \f)Tj /Span<>> BDC ( )Tj EMC (\022\026\004\036\f\021\r\024\n \032\017\027\017 \023\024\f\035\036 \023\ \036\030\036\007\027\036\005 )Tj 0.153 Tw T* (\030\036\036\022\006\017\017 \023\030\016\n\024\005 \022\017\001\022\017\ . \215\024\f\035\036 \024\023\036\030\026\006\017\005 \f)Tj /Span<>> BDC ( )Tj EMC (\r\024\f\f\021\026)Tj 0 Tw (-)Tj 0.257 Tw T* (\027\024\r\035\036\027\017\036\n \026\022\021\026 \007\036\235\036\022\026\ \006\017\017 \f\021\026\021\017\f\021\017\004\036\f\022\017 \027\026\004\ \017\n\024 )Tj 0.524 Tw T* (\031\035\031\004\001\017\035\017\f\034 \f\024\006\017\026\035\034\027\024\ \036 \235\031\027\022\006\017\024\027\017\030\024\r\026\027\017\036 $83\ ,4 )Tj 0.119 Tw T* (\023\030\024\021\017\r 74,6 \002\026\035\035\024\r, )Tj /T1_1 1 Tf 0 Tw (p)Tj /T1_0 1 Tf 0.119 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,045$ \017)Tj /Span<>> BDC ( )Tj EMC (\031\007\024\r\035\036\021\r\024\030\036\027\027\024\f\021\034 )Tj 0.181 Tw T* [(\r\017\007\024\n \f\024\002\f\021\r\036\027\027\024\020\024 \021\036\035\ \026 )0.5($82,5 \023\030\024\021\017\r )0.5(67,9 \002\026\035\035\024\r, )]TJ /T1_1 1 Tf 0 Tw T* (p)Tj /T1_0 1 Tf 0.095 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,01$, \b\024\021\016 \004\026\013\036 \024\021\n\036\004\026\035\017\f\ \034 \023\030\024\002\035\036\n\t \f)Tj /Span<>> BDC ( )Tj EMC (\220\r\026\022\031\026)Tj 0 Tw (-)Tj 0.027 Tw T* (\021\024\030\027\024\005 \235\031\027\022\006\017\036\005 \022\017\001\036\ \004\027\017\022\026 $22,6 \023\030\024\021\017\r 11 \002\026\035\035\024\ \r, )Tj /T1_1 1 Tf 0 Tw T* (p)Tj /T1_0 1 Tf 0.003 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC 1.449 0 Td (0,032$. \203\036\f\n\024\021\030\016 \027\026)Tj /Span<>> BDC ( )Tj EMC 8.472 0 Td [(\f\031\013\036\f\021\r\036\027\027\t\036 )0.5(\n\036\021\024\007\024\035\024\020\017\004\036)]TJ 0 Tw (-)Tj 0.022 Tw -9.921 -1.218 Td (\f\022\017\036 \027\036\007\024\f\021\026\021\022\017 \007\026\027\027\024\ \005 \030\026\002\024\021\t, \023\030\036\007\035\024\032\036\027\027\026\ \016 \026\r\021\024)Tj 0 Tw (-)Tj 0.13 Tw T* (\030\026\n\017 \022\024\027\006\036\023\006\017\016 \023\024\035\027\024\ \f\021\034\033 \022\024\030\030\036\035\017\030\031\036\021 \f)Tj /Span<>> BDC ( )Tj EMC (\023\024\035\031\004\036\027)Tj 0 Tw (-)Tj T* (\027\t\n\017 \027\026\n\017 \030\036\031\035\034\021\026\021\026\n\017.\ )Tj 0.014 Tw T* (\215\030\017 \f\024\023\024\f\021\026\r\017\n\024\n \020\035\024\002\026\ \035\034\027\024\n \022\026\004\036\f\021\r\036 \032\017\027\017 \023\026\ \006\017)Tj 0 Tw (-)Tj 0.088 Tw T* (\036\027\021\t \f)Tj /Span<>> BDC ( )Tj EMC (\023\024\f\021\024\016\027\027\024\005 \f\021\024\n\024\005 \017)Tj /Span<>> BDC ( )Tj EMC (\023\024\f\035\036 \f\235\017\027\022\021\036\030\024\f\024\b\030\026)Tj 0 Tw (-)Tj 0.062 Tw T* (\027\016\033\013\017\b \024\023\036\030\026\006\017\005 \f\021\026\035\022\ \017\r\026\033\021\f\016 \f)Tj /Span<>> BDC ( )Tj EMC (\030\026\027\t\n \023\030\024\235\017\035\036\n )Tj 0.004 Tw T* [(\235\031\027\022\006\017\024\027\026\035\034\027\t\b )0.6(\023\024\f\035\036\007\f\021\r\017\005. )0.5(\225\024\024\021\r\036\021\f\021\r\036\027\027\024, )0.5(\024\021\r\036\021 )]TJ 0.12 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC (\r\024\023\030\024\f\t \024)Tj /Span<>> BDC ( )Tj EMC (\006\036\035\036\f\024\024\002\030\026\027\024\f\021\017 \f\024\b\030\026\ \027\036\027\017\016 \036\f\021\036\f\021)Tj 0 Tw (-)Tj 0.087 Tw T* (\r\036\027\027\024\020\024 \253\026\022\021\026 \007\036\235\036\022\026\ \006\017\017\273 \017)Tj /Span<>> BDC ( )Tj EMC (\004\021\024 \032\036 \f\035\036\007\031\036\021 \f\004\017\021\026\021\034\ )Tj 0.205 Tw T* (\b\024\030\024\001\017\n \022\026\004\036\f\021\r\024\n \032\017\027\017\ \023\024\f\035\036 \024\023\036\030\026\006\017\017? \n\024\032\036\021\ )Tj 0.09 Tw T* (\007\026\021\034 \021\024\035\034\022\024 \f\026\n \023\026\006\017\036\027\ \021, \004\021\024 \023\024\007\021\r\036\030\032\007\026\036\021\f\016 \ \f\017\f\021\036)Tj 0 Tw (-)Tj 0.136 Tw T* [(\n\026\021\017\004\036\f\022\017\n )0.5(\024\002\024\030\024\n \035\017\021\036\030\026\021\031\030\t L)-32(a)10(w)-12(ad)17(y )0.5(S. \017)]TJ /Span<>> BDC ( )Tj EMC 19.56 0 Td (\f\024\026\r\021. )Tj 0.176 Tw -19.56 -1.218 Td ([26], \022\024\021\024\030\t\005 \007\024\f\021\026\021\024\004\027\024 \ \031\002\036\007\017\021\036\035\034\027\024 \023\024\022\026\026\035, \ \004\021\024 )Tj -0.037 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\027\026\f\021\024\016\013\036\036 \r\030\036\n\016 \027\036\r\024\n\024\ \032\027\024 \f\007\036\035\026\021\034 \024\007\027\024\027\026\004\027\ \t\005 )Tj 0.062 Tw T* (\r\t\r\024\007 \024)Tj /Span<>> BDC ( )Tj EMC (\022\026\004\036\f\021\r\036 \032\017\027\017, \235\031\027\022\006\017\ \024\027\026\035\034\027\t\b \017)Tj /Span<>> BDC ( )Tj EMC (\f\017\n\023\021\024)Tj 0 Tw (-)Tj 0.348 Tw T* (\n\026\021\017\004\036\f\022\017\b \023\024\f\035\036\007\f\021\r\017\016\ \b \253\030\036\022\024\027\f\021\030\031\022\021\017\r\027\024\005\273 \ \017\035\017 )Tj 0.202 Tw T* [(\253\024\002\f\021\030\031\022\021\017\r\027\024\005\273 )0.6(\024\023\036\030\026\006\017\017 )0.5(\023\024)]TJ /Span<>> BDC ( )Tj EMC 13.373 0 Td [(\023\024\r\024\007\031 )0.5(\030\026\022\026 )0.6(\023\030\016\n\024\005 )]TJ 0 Tw -13.373 -1.218 Td (\022\017\001\022\017.)Tj 0.042 Tw T* (\217\026\031\n\036\036\021\f\016, \031\004\017\021\t\r\026\016 \r\t\f\024\ \022\031\033 \020\036\021\036\030\024\020\036\027\027\024\f\021\034 \r\022\ \035\033)Tj 0 Tw (-)Tj 0.321 Tw T* (\004\036\027\027\t\b \r)Tj /Span<>> BDC ( )Tj EMC (\027\026\001\031 \030\026\002\024\021\031 \017\f\f\035\036\007\024\r\026\ \027\017\005, \026)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\032\036 \017\b )Tj 0.617 Tw 23.244 64.543 Td [(\030\036\021\030\024\f\023\036\022\021\017\r\027\t\005 )0.6(\b\026\030\026\022\021\036\030 )0.6(\024\007\027\024\027\026\004\027\t\036 )0.6(\r\t\r\024\007\t )]TJ 0.126 Tw T* (\007\036\035\026\021\034 \023\024\022\026 \023\030\036\032\007\036\r\030\ \036\n\036\027\027\024. \200\024\023\030\024\f \024)Tj /Span<>> BDC ( )Tj EMC (\f\235\017\027\022\021\036\030\024)Tj 0 Tw (-)Tj 0.072 Tw T* (\f\024\b\030\026\027\016\033\013\036\n \b\017\030\031\030\020\017\004\036\ \f\022\024\n \r\n\036\001\026\021\036\035\034\f\021\r\036 \007\024\035\032\ \036\027 )Tj 0.355 Tw T* (\030\036\001\026\021\034\f\016 \f)Tj /Span<>> BDC ( )Tj EMC (\031\004\036\021\024\n \017\027\007\017\r\017\007\031\026\035\034\027\t\b\ \024\f\024\002\036\027\027\024\f\021\036\005 )Tj 0.178 Tw T* (\022\026\032\007\024\020\024 \022\024\027\022\030\036\021\027\024\020\024\ \023\026\006\017\036\027\021\026, \021\036\n \002\024\035\036\036 \004\021\ \024 \023\030\024)Tj 0 Tw (-)Tj -0.014 Tw T* [(\r\036\007\036\027\027\t\005 )0.5(\n\036\021\026\026\027\026\035\017 )0.6(\027\036 )0.5(\031\004\017\021\t\r\026\036\021 )0.6(\024\f\024\002\036\027\027\024\f\021\017 )0.5(\r\024\f)]TJ 0 Tw (-)Tj 0.083 Tw 0 -1.218 TD (\023\030\017\016\021\017\016 \007\017\026\020\027\024\026 \017)Tj /Span<>> BDC ( )Tj EMC (\023\024\f\035\036\007\f\021\r\017\005 \035\036\004\036\027\017\016 \023\ \026\006\017\036\027\021\024\r )Tj 0.004 Tw 0 -1.218 TD (\017)Tj /Span<>> BDC ( )Tj EMC (\217\024\f\f\017\017, \004\021\024 \021\026\022\032\036 \016\r\035\016\036\ \021\f\016 \f\031\013\036\f\021\r\036\027\027\t\n \024\020\030\026\027\017\ )Tj 0 Tw (-)Tj T* (\004\036\027\017\036\n \027\026\f\021\024\016\013\036\020\024 \017\f\f\035\ \036\007\024\r\026\027\017\016.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 303.3769 590.8718 Tm [(\020)21(\026\027\r\242\224\034\022\031\034)]TJ 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0 Tc 0.114 Tw 10 0 0 10 303.3071 566.5158 Tm [(\215\030\017 )0.5(\n\036\021\026\026\027\026\035\017\036 )0.6(\007\026\027\027\t\b )0.5(\035\017\021\036\030\026\021\031\030\t )0.5(\027\026\004\017\n\t\b )0.5(\030\026)]TJ 0 Tw (-)Tj 0.028 Tw T* (\035\017\004\017\005 \r)Tj /Span<>> BDC ( )Tj EMC (\020\035\024\002\026\035\034\027\024\n \022\026\004\036\f\021\r\036 \032\ \017\027\017 \n\036\032\007\031 \020\030\031\023\023\026\n\017 )Tj -0.002 Tw T* [(\023\026\006\017\036\027\021\024\r )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC [(\235\024\030\n\017\030\024\r\026\027\017\036\n )0.5(\023\024\f\021\024\016\027\027\024\005 )0.5(\f\021\024\n\t \017)]TJ /Span<>> BDC ( )Tj EMC 20.757 0 Td (\023\024)Tj 0 Tw (-)Tj 0.071 Tw -20.757 -1.218 Td (\f\035\036 \024\023\036\030\026\006\017\005 \f)Tj /Span<>> BDC ( )Tj EMC (\r\024\f\f\021\026\027\024\r\035\036\027\017\036\n \026\022\021\026 \007\ \036\235\036\022\026\006\017\017 \027\036 )Tj -0.02 Tw T* [(\r\t\016\r\035\036\027\024. )0.6(\225\021\026\021\017\f\021\017\004\036\f\022\017 )0.5(\027\026\004\017\n\026\016 )0.6(\030\026\027\017\006\026 )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC 18.967 0 Td (\b\031\007\001\017\n )Tj 0.051 Tw -18.967 -1.218 Td (\023\024\022\026\026\021\036\035\036\n \031)Tj /Span<>> BDC ( )Tj EMC [(\f\021\024\n\017\030\024\r\026\027\027\t\b )0.5(\023\026\006\017\036\027\021\024\r \024\021\n\036\004\026\036\021\f\016 \ )]TJ 0.168 Tw T* (\023\024)Tj /Span<>> BDC ( )Tj EMC (\001\022\026\035\036 \235\017\017\004\036\f\022\024\020\024 \017)Tj /Span<>> BDC ( )Tj EMC (\030\024\035\036\r\024\020\024 \235\031\027\022\006\017\024\027\017\030\024\ \r\026)Tj 0 Tw (-)Tj 0.162 Tw T* (\027\017\016. \215\026\006\017\036\027\021\t \f)Tj /Span<>> BDC ( )Tj EMC (\023\024\f\021\024\016\027\027\024\005 \f\021\024\n\024\005 \002\024\035\ \036\036 \023\024\007\r\036\030)Tj 0 Tw (-)Tj 0.311 Tw T* (\032\036\027\t \027\026\030\031\001\036\027\017\016\n \220\n\024\006\017\ \024\027\026\035\034\027\024\020\024 \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\006\017\026\035\034\027\024\020\024 )Tj 0.289 Tw T* (\235\031\027\022\006\017\024\027\017\030\024\r\026\027\017\016. \215\030\ \017)Tj /Span<>> BDC ( )Tj EMC (\024\006\036\027\022\036 \f\017\n\023\021\024\n\026\021\017\004\036\f\022\ \017\b )Tj 0.042 Tw T* (\001\022\026\035 \023\026\006\017\036\027\021\t \f\024 \f\021\024\n\024\005\ \002\t\f\021\030\036\036 \031\f\021\026\033\021. \203\026\023\030\024\021\ \017\r, )Tj -0.008 Tw T* (\031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \023\024\f\035\036 \f\235\017\027\022\ \021\036\030\024\f\024\b\030\026\027\016\033\013\017\b \024\023\036\030\026\ \006\017\005 )Tj 0 Tw T* (\024\021\n\036\004\026\036\021\f\016 \002\024\035\036\036 \r\t\f\024\022\ \026\016 \004\026\f\021\024\021\026 \026\023\024\030\024\r \017)Tj /Span<>> BDC ( )Tj EMC (\007\017\026\030\036\017.)Tj /T1_3 1 Tf 0.023 Tw 0 -2.436 TD (\223\030\032\255\020\034\036 \032\026\020\017\022\017\026)Tj /T1_0 1 Tf 0 Tw 0 -1.218 TD [(\025)-4.1(\024)-4.3(\027)1.7(\006)-6(\036)-6.8(\023)2.2(\006)-6(\017)-5.4(\016 \017)]TJ /Span<>> BDC ( )Tj EMC [(\007)-6(\017)2.7()-9.9(\026\005)1.8(\027 \017)-2.4(\f)3.1(\f)-38.9(\035)-6.8(\036)-19(\007)-4.4(\024)-4.3(\r)-8.9(\026\027)1.7(\017)-5.5(\016)13.7(:)]TJ /T1_1 1 Tf -0.01 Tc 0.01 Tw [( \224)6.6(\034)-7.6(\003)-1.2(\030)0.8(\021\034\036)]TJ /Span<>> BDC 18.434 0 Td ( )Tj EMC [(\220)12.8(.)-2.7(\223)-12.2(.)]TJ /T1_0 1 Tf 0 Tc 0.861 Tw -18.434 -1.218 Td [(\225)-4.6(\002)-9.9(\024)0.7(\030 \017)]TJ /Span<>> BDC ( )Tj EMC [(\024)-11.8(\002)3(\030)-11.4(\026)-6.3(\002)-9.9(\024)-10.9(\021)-17.7(\022)-19.1(\026 \n)1.3(\026)-11.8(\021)-9.9(\036)-1.7(\030)-7.6(\017)-0.6(\026)-33.1(\035\026)3.7(:)]TJ /T1_1 1 Tf -0.01 Tc 0.871 Tw [( \224)6.6(\034)-7.6(\003)-1.2(\030)0.8(\021\034\036)]TJ /Span<>> BDC 19.24 0 Td ( )Tj EMC [(\220)12.8(.)-2.7(\223)-12.3(.)-2.2(,)-10( )]TJ 0.01 Tw -19.24 -1.218 Td [(\223)9.9(\025)-4(\033)-7(\037)-8.2(\003)-6(\016)-7.7(\020)0.7(\021\034\036)]TJ /Span<>> BDC 4.836 0 Td ( )Tj EMC [(\206)14.3(.)17.5(\006)8.6(.)]TJ /T1_0 1 Tf 0.002 Tc -0.002 Tw -4.836 -1.218 Td [(\203)7.2(\026\023)4.2(\017\f)-10.8(\026)1.7(\027)3.7(\017)-6.7(\036)2.1( \021)-7.9(\036)-3.4(\022\f)-34(\021)-19.5(\026)5.7(:)]TJ /T1_1 1 Tf -0.01 Tc 0.01 Tw 7.694 0 Td [( \224)6.6(\034)-7.5(\003)-1.2(\030)0.7(\021\034\036)]TJ /Span<>> BDC 3.566 0 Td ( )Tj EMC [(\220)12.8(.)-2.7(\223)-12.2(.)-2.2(,)-10( \223)9.9(\025)-4(\033)-7(\037)-8.3(\003)-5.9(\016)-7.7(\020)0.7(\021\034\036)]TJ /Span<>> BDC 7.078 0 Td ( )Tj EMC [(\206)14.3(.)17.5(\006)8.6(.)]TJ /T1_0 1 Tf 0 Tc 0 Tw -18.338 -1.218 Td [(\217)5.5(\036)-19(\007)-20.1(\026\022)-32.6(\021)-17.7(\017)1.5(\030)-11.8(\024)-4.4(\r)-8.8(\026\027)1.8(\017)-8.7(\036)6.5(:)]TJ /T1_1 1 Tf 0.828 Tw [( \210)23.8(\032)1.7(\025)4.7(\037)4.8(\021)9.9(\034)9.6(\036)]TJ /Span<>> BDC ( )Tj EMC [(\220)22.8(.)29.3(\221)122(.)7.8(, \203)7.3(\034)-0.7(\024)4(\021)12.7(\037)-5.2(\027)3.3(\016)6.6(\036)]TJ /Span<>> BDC ( )Tj EMC [(\223)-2.3(.)29.3(\200)28.9(.)7.8(, )]TJ -0.028 Tc 0.028 Tw T* [(\217\023)-18.7(\235)-20.8(\021)-18.2(\034)-18.4(\036)]TJ /Span<>> BDC 2.926 0 Td ( )Tj EMC [(\216.)1.3(\221)94(.)]TJ /T1_3 1 Tf 0 Tc 0.023 Tw -2.926 -2.436 Td (AUTHORS CONTRIBUTION)Tj /T1_0 1 Tf -0.02 Tw T* [(C)-6.5(o)0.8(nce)-0.7(p)-12.3(t )0.5(a)2.4(n)-4.6(d d)-5.5(e)-13.3(s)-16.6(i)3.2(g)1.2(n )0.5(o)-2.2(f t)-16.6(h)-5.3(e s)-20(t)-12.8(ud)-10.9(y)-11.8(:)]TJ /T1_1 1 Tf [( E)20.6(v)8.2(g)-2.5(e)-2.6(n)6.2(iy)]TJ /Span<>> BDC ( )Tj EMC 16.616 0 Td [(A)-12.6(.)]TJ /Span<>> BDC ( )Tj EMC 1.059 0 Td [(K)0.7(h)1.9(om)4.8(y)3.8(a)1.7(k)13(o)-0.6(v)]TJ /T1_0 1 Tf 1.665 Tw -17.675 -1.218 Td [(C)-6.5(o)-5.8(l)-19(l)-14.3(e)-9.4(c)-32.5(t)-37.3(i)3.2(o)0.8(n a)2.4(n)-4.6(d p)-3.8(r)-6(o)-6.9(ce)-13.3(s)-12.8(s)-16.6(i)7.1(n)-1.9(g o)-2.2(f m)1.8(a)-8.4(t)-15.2(e)-2.1(r)-48(i)5.1(a)-1.5(l)-22.5(:)]TJ /T1_1 1 Tf 0 Tw ( )Tj T* [(E)20.6(v)8.2(g)-2.5(e)-2.6(n)6.2(iy)]TJ /Span<>> BDC ( )Tj EMC [(A)-12.6(.)]TJ /Span<>> BDC ( )Tj EMC [(K)0.8(h)1.9(om)4.8(y)3.8(a)1.7(k)12.9(o)-0.6(v)33.6(, V)-5.4(i)7.9(k)-20.8(t)1.4(o)1.3(r)]TJ /Span<>> BDC ( )Tj EMC [(B)10.3(.)]TJ /Span<>> BDC ( )Tj EMC [(A)6(b)0.8(r)7.7(a)-0.8(m)-1.1(e)-2.5(n)7.4(k)13(o)-0.6(v)]TJ /T1_0 1 Tf -0.052 Tc -0.074 Tw T* [(Te)-75.9(x)-88(t)-52( w)-73(r)-100(i)-58(t)-89.4(i)-44.9(n)-53.9(g)-43(:)]TJ /T1_1 1 Tf 0 Tc -0.126 Tw 5.107 0 Td [( E)20.6(v)8.2(g)-2.5(e)-2.6(n)6.2(iy)]TJ /Span<>> BDC ( )Tj EMC [(A)-12.6(.)]TJ /Span<>> BDC ( )Tj EMC [(K)0.7(h)1.9(om)4.9(y)3.8(a)1.7(k)12.9(o)-0.6(v)33.6(, V)-5.5(i)7.9(k)-20.8(t)1.4(o)1.3(r)]TJ /Span<>> BDC ( )Tj EMC [(B)10.2(.)]TJ /Span<>> BDC ( )Tj EMC [(A)6(b)0.8(r)7.7(a)-0.8(m)-1.1(e)-2.6(n)7.5(k)13(o)-0.6(v)]TJ /T1_0 1 Tf 0.006 Tc -0.006 Tw -5.107 -1.218 Td [(E)11.6(dit)-31.4(i)13.1(n)4.1(g)15(:)]TJ /T1_1 1 Tf 0 Tc 0.551 Tw 3.238 0 Td [( E)20.7(v)8.2(g)-2.5(e)-2.6(n)6.2(y)]TJ /Span<>> BDC ( )Tj EMC [(G)-1.4(.)]TJ /Span<>> BDC ( )Tj EMC [(R)-9(y)6.9(ba)1.7(k)13(o)-0.6(v)33.6(, A)3.6(l)4.8(ek)-17.5(s)4.9(e)-2.5(y)]TJ /Span<>> BDC ( )Tj EMC [(I)2.4(.)]TJ /Span<>> BDC ( )Tj EMC [(M)2.3(o)3.3(s)9.1(k)15.8(al)4.8(e)-4(v)33.6(, )]TJ 0 Tw -3.238 -1.218 Td [(O)-7.4(l)4.8(e)-3.5(g)]TJ /Span<>> BDC ( )Tj EMC [(G)-1.3(.)]TJ /Span<>> BDC ( )Tj EMC [(S)15.8(us)9.6(h)7.5(k)12.9(o)-0.6(v)]TJ /T1_3 1 Tf 0.023 Tw 0 -2.436 TD (\255\026\036\031\036\025\034\224 \017\222 \032\026\020\017\022\032\231 $\ ORCID$)Tj /T1_0 1 Tf 0.134 Tw 0 -1.218 TD (\216\024\n\016\022\024\r \213\r\020\036\027\017\005 \202\035\036\022\f\026\ \027\007\030\024\r\017\004)Tj /Span<>> BDC ( )Tj EMC (\227 \022.\n.\027., \027\026\031\004\027\t\005 )Tj 0.461 Tw T* [(\f\024\021\030\031\007\027\017\022 \024\021\007\036\035\026 )0.5(\024\027\022\024\023\030\024\022\021\024\035\024\020\017\017 \205\206\207\ \211 \253\203\204\224\037 )]TJ 0.482 Tw T* (\022\024\035\024\023\030\024\022\021\024\035\024\020\017\017 \017\n\036\027\ \017 \202.\203. \217\t\032\017\b\273 \204\017\027\007\030\026\r\026 )Tj 0.134 Tw T* (\217\024\f\f\017\017, \026\f\f\017\f\021\036\027\021 \022\026\235\036\007\ \030\t \022\024\035\024\023\030\024\022\021\024\035\024\020\017\017 \205\ \206\207\210\211 )Tj 0 Tw T* (\212\215\210 \217\204\202\203\215\210; ORCID 0000-0002-3399-0608)Tj 0.207 Tw T* (\202\002\030\026\n\036\027\022\024\r \200.\207.)Tj /Span<>> BDC ( )Tj EMC (\227 \024\030\007\017\027\026\021\024\030 \205\206\207\211 \253\203\204\224\ \037 \022\024\035\024)Tj 0 Tw (-)Tj 0.08 Tw T* (\023\030\024\022\021\024\035\024\020\017\017 \017\n\036\027\017 \202.\203\ . \217\t\032\017\b\273 \204\017\027\007\030\026\r\026 \217\024\f\f\017\017\ ; )Tj 0 Tw T* (ORCID 0009-0005-4677-1841)Tj 0.402 Tw T* (\217\t\002\026\022\024\r \213.\206.)Tj /Span<>> BDC ( )Tj EMC (\227 \007.\n.\027., \023\030\024\235\036\f\f\024\030 \217\202\203, \030\031\ \022\024\r\024)Tj 0 Tw (-)Tj 0.829 Tw T* (\007\017\021\036\035\034 \024\021\007\036\035\026 \024\027\022\024\023\030\ \024\022\021\024\035\024\020\017\017 \205\206\207\211 \253\203\204\224\037\ )Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 0 Tw 7.5 0 0 7.5 70.8661 759.8869 Tm [(\215\204\032)50(\021\021\217\021)-21(\035\030\210)]TJ 53.418 0 Td [(MET)30(A)-41(-)-41.9(ANAL)30(Y)30(SIS)]TJ -53.418 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 23, \023\0222, 202)69(4)]TJ 42.99 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 23, \023\0222, 202)69(4)]TJ /T1_5 1 Tf 25 0 0 25 20.8276 56.0378 Tm (170)Tj ET endstream endobj 639 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\037)41(\016\020\t\r)-10(\026\f\025 \226\005\220\004\005 \225\016\255\005\t\004\026)11(\025\f \r\022\225\025\r)-10(\026)11(\025\200\004\004\025\201 \017)10(\025\b\025\r)-10(\026)11(\025\024\025\201 \005\022\225\025\r)-10(\b\t )]TJ 0 -1 TD [(\025\225\t\235\016\255\005\201 \r\022\f\025\r\r)-10(\026)11(\016\004\025\f\b\t\004\005\t\024 \004\t\225\235\t\235\007\f\004\025\r)-9.9(\026\005 \017\005\203\t\020\004\005\017\016 $\024\t\026)11(\016\016\004\016\b\005\220$)]TJ 40.058 1 Td [(Qualit)-19.9(y of life of patients with permanent colostom)21(y )]TJ 3.336 -1 Td [(and low anterior r)31(esections $meta-analy)10(sis$)]TJ /T1_1 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 42.5896 724.8299 Tm [(\037\036)10(\032\223\212\226\034\022\031\034)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf 0.02 Tc 0.119 Tw 10 0 0 10 42.5197 700.4739 Tm [(\230\r\024\035\033\006\017\016 \021\026\022\021\017\022\017 \035\036\004\ \036\027\017\016 \030\026\022\026 \023\030\016\n\024\005 \022\017\001\022\ \017 \024\021)20( )]TJ 0.073 Tw 0 -1.218 TD [(\024\002\016\026\021\036\035\034\027\024\020\024 )0.6(\235\024\030\n\017\030\024\r\026\027\017\016 )0.5(\023\024\032\017\027\036\027\027\024\005 )0.5(\f\021\024\n\t)20( )]TJ -0.008 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\b\024\007\036 \b\017\030\031\030\020\017\004\036\f\022\017\b \024\023\036\ \030\026\006\017\005 \022)Tj /Span<>> BDC ( )Tj EMC (\n\031\035\034\021\017\007\017\f\006\017\023\035\017)Tj 0 Tc 0 Tw (-)Tj 0.02 Tc 0.29 Tw T* (\027\026\030\027\024\n\031 \023\024\007\b\024\007\031 \f)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\r\036\007\036\027\017\036\n \022\024\n\002\017\027\017\030\024\ \r\026\027)Tj 0 Tc 0 Tw (-)Tj 0.02 Tc 0.115 Tw T* (\027\024\020\024 \035\036\004\036\027\017\016 \f)Tj /Span<>> BDC ( )Tj EMC (\017\f\023\024\035\034\024\r\026\027\017\036\n \b\017\n\017\024- \017\035\ \017 \035\031\004\036)Tj 0 Tc 0 Tw (-)Tj 0.02 Tc 0.108 Tw 0 -1.218 TD [(\r\024\005 \021\036\030\026\023\017\017 \024\002\036\f\023\036\004\017\035\ \026 \r\024\n\024\032\027\024\f\021\034 \f\024\b\030\026\027\036\027\017\ \016)20.1( )]TJ 0.577 Tw 0 -1.218 TD (\036\f\021\036\f\021\r\036\027\027\024\020\024 \026\022\021\026 \007\036\ \235\036\022\026\006\017\017 \031)Tj /Span<>> BDC ( )Tj EMC [(\002\024\035\034\001\017\027\f\021\r\026)20( )]TJ -0.02 Tw T* (\002\024\035\034\027\t\b.)Tj 0 Tc 0.111 Tw T* (\207\036\031\f\035\024\r\027\024, \024\027\022\024\035\024\020\017\004\036\ \f\022\026\016 \f\024\f\021\026\r\035\016\033\013\026\016 \017)Tj /Span<>> BDC ( )Tj EMC (\f\021\030\036\n)Tj 0 Tw (-)Tj 0.324 Tw T* (\035\036\027\017\036 \022)Tj /Span<>> BDC ( )Tj EMC (\030\026\007\017\022\026\035\034\027\024\f\021\017 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\r\t\023\024\035\027\036\027\017\017 \b\017\030\031\030\020\017)Tj 0 Tw (-)Tj 0.384 Tw 0 -1.218 TD [(\004\036\f\022\024\020\024 )0.5(\r\n\036\001\026\021\036\035\034\f\021\r\026 )0.6(\023\024)]TJ /Span<>> BDC ( )Tj EMC 12.216 0 Td [(\023\024\r\024\007\031 )0.5(\030\026\022\026 )0.6(\016\r\035\016\033\021\f\016 )]TJ 0.524 Tw -12.216 -1.218 Td (\024\f\027\024\r\027\t\n\017 \235\026\022\021\024\030\026\n\017 \r\t\002\ \024\030\026 \024\002\255\036\n\026 \030\036\036\022\006\017\017 )Tj 0.129 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\024\023\030\036\007\036\035\016\033\021 \r\024\n\024\032\027\024\f\021\ \034 \f\024\b\030\026\027\036\027\017\016 \026\023\017\030\026\021\036\035\ \034)Tj 0 Tw (-)Tj 0 -1.218 TD (\027\024\020\024 \026\023\023\026\030\026\021\026 [21].)Tj 0.286 Tw 0 -1.218 TD (\210\007\027\026\022\024, \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\f\024\023\024\f\021\026\r\017\n\024\005 \030\026\007\017\022\026\035\034\ \027\024\f\021\017 \035\036\004\036\027\017\016 )Tj 0.057 Tw 0 -1.218 TD [(\r\t\002\024\030 )0.5(\n\036\032\007\031 )0.6(\024\002\f\021\030\031\022\021\017\r\027\024\005 )0.6(\030\036\036\022\006\017\036\005 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 17.666 0 Td (\024\023\036\030\026\006\017\036\005 )Tj 0.331 Tw -17.666 -1.218 Td (\f)Tj /Span<>> BDC ( )Tj EMC (\r\024\f\f\021\026\027\024\r\035\036\027\017\036\n \036\f\021\036\f\021\r\ \036\027\027\024\020\024 \026\022\021\026 \007\036\235\036\022\026\006\017\ \017 )Tj 0.241 Tw 0 -1.218 TD [(\027\036 \027\026\f\021\024\035\034\022\024 \024\004\036\r\017\007\036\027\ . \204\036\021\026\026\027\026\035\017 P)30(eng B. \017)]TJ /Span<>> BDC ( )Tj EMC (\f\024)Tj 0 Tw (-)Tj 0.402 Tw T* (\026\r\021., \024\002\255\036\007\017\027\017\r\001\017\005 \030\036\031\ \035\034\021\026\021\t 12 \017\f\f\035\036\007\024\r\026\027\017\005, )Tj 0.227 Tw 0 -1.218 TD (\r)Tj /Span<>> BDC ( )Tj EMC (\022\024\021\024\030\t\b \023\030\017\027\016\035\017 \031\004\026\f\021\ \017\036 2438 \023\026\006\017\036\027\021\024\r, \023\036\030\036)Tj 0 Tw (-)Tj 0.232 Tw 0 -1.218 TD (\027\036\f\001\017\b \017\027\021\036\030\f\235\017\027\022\021\036\030\027\ \031\033 \030\036\036\022\006\017\033 \017\035\017 \002\030\033\001\027\ \024-)Tj -0.013 Tw 0 -1.218 TD [(\023\030\024\n\036\032\027\024\f\021\027\031\033 )0.5(\220\022\f\021\017\030\023\026\006\017\033 \023\030\016\n\024\005 \022\017\ \001\022\017, \023\024\022\026\026\035 )]TJ 0.205 Tw T* (\030\026\035\017\004\017\016 \035\017\001\034 \r)Tj /Span<>> BDC ( )Tj EMC (\f\030\024\022\026\b \023\030\036\002\t\r\026\027\017\016 \r)Tj /Span<>> BDC ( )Tj EMC (\f\021\026\006\017\024\027\026\030\036 )Tj 0.021 Tw T* ($\030\026\027\017\006\026 \f\030\036\007\027\017\b \2472,98 \007\027\036\ \005; 95% \212\224: \2473,54)Tj /Span<>> BDC ( )Tj EMC (\227 \2472,4; )Tj /T1_3 1 Tf 0 Tw T* (p)Tj /T1_2 1 Tf -0.004 Tw /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (0,00001$ \017)Tj /Span<>> BDC ( )Tj EMC (\r\036\030\024\016\021\027\024\f\021\034\033 \030\026\r\017\021\017\016\ \023\024\f\035\036\024\023\036\030\026\006\017)Tj 0 Tw (-)Tj 0.15 Tw T* (\024\027\027\t\b \024\f\035\024\032\027\036\027\017\005 $\210\221)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,76; 95% \212\224: 0,59\2260,99; )Tj /T1_3 1 Tf 0 Tw T* (p)Tj /T1_2 1 Tf 0.002 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,04$ \r)Tj /Span<>> BDC ( )Tj EMC (\023\024\035\034\031 \017\027\021\036\030\f\235\017\027\022\021\036\030\ \027\t\b \030\036\036\022\006\017\005, \027\024 \027\036 )Tj 0 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\024\027\022\024\035\024\020\017\004\036\f\022\017\b \030\036\031\035\034\ \021\026\021\026\b \035\036\004\036\027\017\016 [9].)Tj 0.219 Tw T* [(\025\024\027\036\004\027\024, \f\031\013\036\f\021\r\036\027\027\t\n )0.5(\024\020\030\026\027\017\004\036\027\017\036\n \007\026\027\027\024\020\024\ \n\036)]TJ 0 Tw (-)Tj 0.208 Tw T* (\021\026\026\027\026\035\017\026 \016\r\035\016\036\021\f\016 \027\026\ \004\017\n\026\016 \030\026\027\017\006\026 \n\036\032\007\031 \020\030\ \031\023)Tj 0 Tw (-)Tj 0.31 Tw T* (\023\026\n\017 \r)Tj /Span<>> BDC ( )Tj EMC (\023\026\021\024\n\024\030\235\024\035\024\020\017\004\036\f\022\024\005\ \231-\f\021\026\007\017\017 $)Tj /T1_3 1 Tf 0 Tw (p)Tj /T1_2 1 Tf 0.31 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,01$ )Tj 0.094 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (N-\f\021\026\007\017\017 \026\002\024\035\036\r\026\027\017\016 $)Tj /T1_3 1 Tf 0 Tw (p)Tj /T1_2 1 Tf 0.094 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,06$, \024\022\026\026\r\001\017\b\f\016 \002\024)Tj 0 Tw (-)Tj 0.162 Tw T* (\035\036\036 \027\017\022\017\n\017 \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \017\027\021\036\030\f\235\017\027\022\021\036\030\ \027\t\b \030\036\036\022\006\017\005, )Tj 0.227 Tw T* (\004\021\024 \002\036\031\f\035\024\r\027\024 \023\024\r\t\001\026\036\021\ \r\036\030\024\016\021\027\024\f\021\034 \r\t\023\024\035\027\036\027\017\ \016 )Tj 0.505 Tw T* (\030\036\022\024\027\f\021\030\031\022\021\017\r\027\024\020\024 \220\021\ \026\023\026 \024\023\036\030\026\006\017\017 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\f\024\024\021\r\036\021)Tj 0 Tw (-)Tj 0.077 Tw T* (\f\021\r\031\033\013\036\005 \030\026\f\023\030\024\f\021\030\026\027\036\ \027\027\024\f\021\017 \024\023\031\b\024\035\017, \027\024, \r)Tj /Span<>> BDC ( )Tj EMC (\035\033\002\024\n )Tj 0.184 Tw 23.244 45.059 Td (\f\035\031\004\026\036, \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\024\021\027\024\f\017\021\036\035\034\027\024 \r\t\f\024\022\017\b \023\ \024\022\026\026\021\036\035\016\b \r\t)Tj 0 Tw (-)Tj -0.003 Tw T* (\032\017\r\026\036\n\024\f\021\017 \027\026\004\017\021\036\035\034\027\ \024\036 \022\024\035\017\004\036\f\021\r\024 \023\026\006\017\036\027\021\ \024\r, \022\026\022 )Tj 0.098 Tw T* (\f\024 \f\021\024\n\024\005, \021\026\022 \017)Tj /Span<>> BDC ( )Tj EMC (\002\036 \027\036\036 \f\021\026\035\022\017\r\026\033\021\f\016 \f)Tj /Span<>> BDC ( )Tj EMC (\023\024\002\024\004\027\t\n\017 )Tj 0.219 Tw T* [(\220\235\235\036\022\021\026\n\017 \035\036\004\036\027\017\016, )0.5(\022\024\021\024\030\t\036 \024\022\026\t\r\026\033\021 \f\036\030\034\036\ \027\024\036 )]TJ 0.013 Tw T* (\r\035\017\016\027\017\036 \027\026)Tj /Span<>> BDC ( )Tj EMC (\022\026\004\036\f\021\r\024 \032\017\027\017 \r)Tj /Span<>> BDC ( )Tj EMC (\007\024\035\020\024\f\030\024\004\027\024\005 \023\036\030\f\023\036\022\ )Tj 0 Tw (-)Tj T* (\021\017\r\036 [22].)Tj 0.104 Tw T* (\203\026\017\002\024\035\036\036 \024\004\036\r\017\007\027\t\n \235\026\ \022\021\024\030\024\n, \r\035\017\016\033\013\017\n \027\026)Tj /Span<>> BDC ( )Tj EMC (\022\026\004\036)Tj 0 Tw (-)Tj 0.129 Tw 0 -1.218 TD (\f\021\r\024 \032\017\027\017 \002\024\035\034\027\t\b \030\026\022\024\ \n \023\030\016\n\024\005 \022\017\001\022\017, \016\r\035\016\036\021\f\ \016 )Tj 0.211 Tw 0 -1.218 TD (\027\036\024\002\b\024\007\017\n\024\f\021\034 \235\024\030\n\017\030\024\ \r\026\027\017\016 \f\021\024\n\t. \210\007\027\026\022\024 \007\026\032\ \036 )Tj 0.061 Tw T* (\023\030\017)Tj /Span<>> BDC ( )Tj EMC [(\f\235\017\027\022\021\036\030\024\f\024\b\030\026\027\016\033\013\036\n\ )0.5(\035\036\004\036\027\017\017 \f)]TJ /Span<>> BDC ( )Tj EMC (\f\024\b\030\026\027\036\027\017\036\n )Tj 0 Tw T* [(\024\002\030\026\026 \021\036\035\026 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC [(\036\f\021\036\f\021\r\036\027\027\024\020\024 )0.5(\026\022\021\026 \007\036\235\036\022\026\006\017\017 )0.5(\023\026\006\017\036\027)]TJ (-)Tj 0.122 Tw T* (\021\t \f\021\026\035\022\017\r\026\033\021\f\016 \f)Tj /Span<>> BDC ( )Tj EMC (\r\t\030\026\032\036\027\027\t\n\017 \235\031\027\022\006\017\024\027\026\ \035\034\027\t\n\017 )Tj 0.093 Tw 0 -1.218 TD (\027\026\030\031\001\036\027\017\016\n\017, \024\002\031\f\035\024\r\035\ \036\027\027\t\n\017 \023\030\024\016\r\035\036\027\017\016\n\017 \f\017\ \027\007)Tj 0 Tw (-)Tj 0 -1.218 TD (\030\024\n\026 \027\017\022\024\005 \023\036\030\036\007\027\036\005 \030\ \036\036\022\006\017\017 [23].)Tj 0.109 Tw 0 -1.218 TD [(\212\026\027\027\026\016 )0.5(\022\026\021\036\020\024\030\017\016 )0.6(\023\026\006\017\036\027\021\024\r )0.5(\n\024\032\036\021 )0.5(\017\n\036\021\034 )0.6(\026\r\t\001\036\027)]TJ 0 Tw (-)Tj 0.242 Tw 0 -1.218 TD (\027\t\036 \024\032\017\007\026\027\017\016 \023\036\030\036\007 \024\023\ \036\030\026\006\017\036\005, \027\024, \f\021\024\035\022\027\031\r\001\ \017\f\034 )Tj 0.627 Tw 0 -1.218 TD (\f)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(\023\024\f\035\036\007\f\021\r\017\016\n\017 )0.5(\b\017\030\031\030\020\017\004\036\f\022\024\020\024 )0.5(\r\n\036\001\026\021\036\035\034\f\021\r\026, )]TJ 0.493 Tw -1.296 -1.218 Td (\030\026\024\004\026\030\024\r\026\021\034\f\016 \r)Tj /Span<>> BDC ( )Tj EMC (\235\031\027\022\006\017\024\027\026\035\034\027\t\b \023\024\f\035\036\007\ \f\021\r\017\016\b. )Tj 0.165 Tw 0 -1.218 TD [(\203\026\023\030\024\021\017\r, \023\026\006\017\036\027\021\t \023\024\f\ \035\036 \024\002\f\021\030\031\022\021\017\r\027\t\b )0.5(\030\036\036\022\006\017\005 )]TJ 0.198 Tw 0 -1.218 TD (\024\002\t\004\027\024 \017\f\023\t\021\t\r\026\033\021 \031\027\t\027\017\ \036 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\n\t\f\035\017 \024)Tj /Span<>> BDC ( )Tj EMC (\023\024\f\021\024\016\027)Tj 0 Tw (-)Tj 0.038 Tw T* (\027\024\005 \f\021\024\n\036. \210\007\027\026\022\024, \022\024\020\007\ \026 \017\n \f\021\026\027\024\r\017\021\f\016 \023\024\027\016\021\027\024\ , \004\021\024 )Tj 0.026 Tw 0 -1.218 TD (\024\027\017 \f\023\024\f\024\002\027\t \031\f\023\036\001\027\024 \026\ \002\024\021\017\021\034\f\016 \024)Tj /Span<>> BDC ( )Tj EMC (\f\036\002\036 \017)Tj /Span<>> BDC ( )Tj EMC (\r\036\f\021\017 \026\022)Tj 0 Tw (-)Tj 0.075 Tw 0 -1.218 TD (\021\017\r\027\t\005 \024\002\030\026 \032\017\027\017, \017\b \031\030\ \024\r\036\027\034 \031\007\024\r\035\036\021\r\024\030\036\027\027\024\f\ \021\017 )Tj 0.022 Tw 0 -1.218 TD [(\035\036\004\036\027\017\036\n )0.5(\027\026\004\017\021\036\035\034\027\024 )0.6(\023\024\r\t\001\026\036\021\f\016. )0.6(\230\021\024\021 )0.5(\235\026\022\021 )0.5(\024\002\255\016\f)]TJ 0 Tw (-)Tj 0.17 Tw T* [(\027\016\036\021 )0.5(\024\021\f\031\021\f\021\r\017\036 )0.6(\f\031\013\036\f\021\r\036\027\027\t\b )0.6(\030\026\035\017\004\017\005 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 18.491 0 Td (\022\026\004\036\f\021\r\036 )Tj 0.129 Tw -18.491 -1.218 Td (\032\017\027\017 \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \023\024\f\035\036 \030\026\035\017\004\ \027\t\b \b\017\030\031\030\020\017\004\036\f\022\017\b )Tj 0 Tw T* (\r\n\036\001\026\021\036\035\034\f\021\r \023\024)Tj /Span<>> BDC ( )Tj EMC (\023\024\r\024\007\031 \030\026\022\026 \023\030\016\n\024\005 \022\017\001\ \022\017 [24].)Tj 0.063 Tw T* [(\225\024\020\035\026\f\027\024 \023\024\035\031\004\036\027\027\t\n )0.6(\027\026\n\017 \007\026\027\027\t\n, )0.5(\023\030\017)]TJ /Span<>> BDC ( )Tj EMC [(\024\006\036\027\022\036 )0.5(\020\035\024)]TJ 0 Tw (-)Tj 0.487 Tw T* (\002\026\035\034\027\024\020\024 \022\026\004\036\f\021\r\026 \032\017\027\ \017 \007\024\f\021\024\r\036\030\027\t\b \030\026\035\017\004\017\005 \ )Tj 0.148 Tw T* (\n\036\032\007\031 \020\030\031\023\023\026\n\017 \f)Tj /Span<>> BDC ( )Tj EMC (\235\024\030\n\017\030\024\r\026\027\017\036\n \023\024\f\021\024\016\027\ \027\024\005 \f\021\024)Tj 0 Tw (-)Tj 0.271 Tw T* (\n\t \017)Tj /Span<>> BDC ( )Tj EMC (\023\024\f\035\036 \f\235\017\027\022\021\036\030\024\f\024\b\030\026\027\ \016\033\013\017\b \024\023\036\030\026\006\017\005 \r\t)Tj 0 Tw (-)Tj 0.186 Tw T* (\016\r\035\036\027\024 \027\036 \002\t\035\024 $)Tj /T1_3 1 Tf 0 Tw (p)Tj /T1_2 1 Tf 0.186 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,11$. \210\007\027\026\022\024 \002\t\035\017 \023\024\035\031\004\036\ \027\t )Tj 0.3 Tw T* (\007\024\f\021\024\r\036\030\027\t\036 \030\026\035\017\004\017\016 \023\ \024)Tj /Span<>> BDC ( )Tj EMC (\235\017\017\004\036\f\022\024\n\031, \030\024\035\036\r\024\n\031, )Tj 0.547 Tw T* [(\220\n\024\006\017\024\027\026\035\034\027\024\n\031 )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC 9.034 0 Td [(\f\024\006\017\026\035\034\027\024\n\031 )0.6(\235\031\027\022\006\017\024\027\017\030\024\r\026)]TJ 0 Tw (-)Tj 0.105 Tw -9.034 -1.218 Td (\027\017\033 $\r\f\036 )Tj /T1_3 1 Tf 0 Tw (p)Tj /T1_2 1 Tf 0.105 Tw /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (0,05$ \f)Tj /Span<>> BDC ( )Tj EMC (\b\031\007\001\017\n\017 \023\024\022\026\026\021\036\035\016\n\017 \031\ )Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017)Tj 0 Tw (-)Tj 0.089 Tw T* [(\036\027\021\024\r, \023\036\030\036\027\036\f\001\017\b )0.5(\024\002\f\021\030\031\022\021\017\r\027\031\033 \030\036\036\022\006\017\ \033 )0.5(\023\030\016\n\024\005 )]TJ 0.688 Tw T* [(\022\017\001\022\017. )0.5(\203\026\023\030\024\021\017\r, )0.5(\023\024\022\026\026\021\036\035\017 )0.6(\f\017\n\023\021\024\n\026\021\017\004\036\f\022\017\b )]TJ 0.137 Tw T* (\001\022\026\035 \r)Tj /Span<>> BDC ( )Tj EMC (\r\017\007\036 \007\017\026\030\036\017 \017)Tj /Span<>> BDC ( )Tj EMC (\026\023\024\030\024\r \002\t\035\017 \027\026\004\017\n\024 \r\t\001\036\ )Tj ET q 42.52 122.695 453.543 132.944 re W n q /GS0 gs 453.543294 0 0 132.9433782 42.5196838 122.6956446 cm /Im0 Do Q Q BT 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 0.105 Tw 9 0 0 9 42.5197 111.7701 Tm (\022\t\217\210\b\002\220 16.)Tj 0 0 0 1 k /GS1 gs /T1_3 1 Tf ( \203\016\035\037\037\020\037\027\022\031 \022)Tj /Span<>> BDC ( )Tj EMC (\004\033\016\036\034\036\022\004\020\032\b \013\033\037\017\022\021 \017\ \022\020\037\020\024\034\036\032 \035\033\023\004\020\034\024\035\016\b\ \023)Tj /Span<>> BDC ( )Tj EMC (\f\037\n\022\016\020\035\034\036 \024)Tj /Span<>> BDC ( )Tj EMC 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