34968%PDF-1.4 % 1 0 obj <>>> endobj 2 0 obj <>stream application/pdf CPL_3(85)2023_block_14-08_v3.indd 2024-02-19T18:43:22+05:00 2024-02-19T18:43:58+05:00 2024-02-19T18:43:58+05:00 Adobe InDesign CS6 (Windows) uuid:ce81601b-d145-4492-8099-e38bbf72609b xmp.did:A755A9BBDED3ED11A964B3B248771B4C xmp.id:BC4FF6C32CCFEE118CAADCFF4804CA6B proof:pdf xmp.iid:BB4FF6C32CCFEE118CAADCFF4804CA6B xmp.did:26E54DB12BCFEE118A53CE1197856127 xmp.did:A755A9BBDED3ED11A964B3B248771B4C default converted from application/x-indesign to application/pdf Adobe InDesign CS6 (Windows) / 2024-02-19T18:43:22+05:00 Adobe PDF Library 10.0.1 False endstream endobj 5 0 obj <> endobj 3 0 obj <> endobj 7 0 obj <> endobj 8 0 obj <> endobj 9 0 obj <> endobj 10 0 obj <> endobj 11 0 obj <> endobj 12 0 obj <> endobj 13 0 obj <> endobj 44 0 obj <> endobj 45 0 obj <> endobj 46 0 obj <> endobj 47 0 obj <> endobj 48 0 obj <> endobj 49 0 obj <> endobj 50 0 obj <> endobj 81 0 obj <>/ExtGState<>/Font<>/ProcSet[/PDF/Text]/Properties<>/Shading<>/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 82 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 83 0 obj <>/Font<>/ProcSet[/PDF/Text/ImageC]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 84 0 obj <>/ExtGState<>/Font<>/ProcSet[/PDF/Text/ImageC/ImageI]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 85 0 obj <>/ExtGState<>/Font<>/ProcSet[/PDF/Text/ImageC/ImageI]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 86 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 87 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 88 0 obj <>/Font<>/ProcSet[/PDF/Text]>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 125 0 obj <>stream 0.2 0.136 0 0.024 k /GS0 gs 70.866 79.37 453.543 171.158 re f BT 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.023 Tw 15 0 0 15 82.2047 228.2549 Tm [(\240)60(\r\013\217\013\016\024\020\016 \017\220\026)11(\013\026)11(\016\007\220!)]TJ 11 0 0 11 82.2047 212.2203 Tm [(\b\002)20(\207\220\r \217\215\002\001\013\007\013 \253\037)31(\025\007\025\221\002\025\n)-10(\026)11(\025\007\025\202\220\205\273 \222\013 2002\234202)69.1(4 \202\202)62(. )]TJ 0 Tw ( )Tj 0.023 Tw 0 -1.2 TD [(\001\013\207\025\201\220\026)21.1(\006\205 \r \025\026\n\002\020\026)11(\025\024 \(\f\016\006\221\007\013\026\001\025\024\) \201\025\006)-10(\026)-20(\215\221\016 \001\013 \006\013\203\026)11.1(\013\207:)]TJ 1 0.68 0 0.12 k /GS0 gs -0.233 Tw 0 -1.458 TD (\242)Tj /Span<>> BDC [( )-500( )]TJ EMC [(www)31(.r)10(upr)20.1(octology)52(.com)]TJ 0.023 Tw 0 -1.715 TD (\242)Tj /Span<>> BDC [( )-244( )]TJ EMC 1.2 0 Td [(\036\f\224\016\002\025\006\006\220\203\006\n)10(\025\203 \025\f\224\016\006)-10(\026\r\016\001\001\025\203 \025\002\202)10(\013\001\220\222\013\227\220\220 )]TJ 0 Tw ( )Tj 0.023 Tw 0 -1.2 TD [(\253\b\006\006\025\227\220\013\227\220\205 \n)10.1(\025\007\025\221\002\025\n)-10(\026)11(\025\007\025\202)10(\025\r \033\025\006\006\220\220\273\022)-23.3(\236 h)-7(t)-28.5(t)-11.9(ps)3.8(:)35.1(/)211.6(/)129.7(a)-6.1(k)-11.8(r)22.5(-)-22.3(o)-6.3(n)-5.1(l)-5.5(i)-6.4(n)-5.3(e)3.2(.)-1.8(r)-15.2(u)56.9(/)]TJ -1.2 -1.715 Td (\242)Tj /Span<>> BDC [( )-244( )]TJ EMC 1.2 0 Td [(\210\031\214)42(\240 \253\213\005\030\226 \n)10(\025\007\025\221\002\025\n)-9.9(\026)11(\025\007\025\202\220\220 \220\024\016\001\220\022)-23.2(\b)-31(.\213.\022)-23.3(\033\020\217\220\207\273 \005\220\001\222\201\002\013\r\013 \033\025\006\ \006\220\220\022)-23.3(\236 )]TJ 0 Tw ( )Tj 0.007 Tc -0.007 Tw 0 -1.2 TD [(ht)-21.5(t)-4.9(p)7.1(s)10.9(:)42.1(/)218.5(/)81.6(w)-30.8(w)-30.8(w)62.3(.)17.9(gn)3.2(c)-10.9(k)-3(.)5.2(r)-8.2(u)63.9(/)]TJ 0 Tc 0.023 Tw -1.2 -1.715 Td (\242)Tj /Span<>> BDC [( )-244( )]TJ EMC 1.2 0 Td [(\213\013\215\017\001\025\203 \232\007\016\n)-9.9(\026\002\025\001\001\025\203 \f\220\f\007\220\025\026)11(\016\n\220\022)-23.3(\236 h)-7(t)-28.5(t)-11.9(ps)3.8(:)35.1(/)211.5(/)74.6(w)-37.8(w)-37.8(w)55.3(.)8.5(e)-8.1(l)-5.5(i)-5.9(b)-7.3(r)1.5(a)-6.1(r)-41.8(y)59.9(.)-1.8(r)-15.2(u)56.9(/)]TJ ET endstream endobj 94 0 obj <> endobj 126 0 obj <> endobj 127 0 obj <> endobj 128 0 obj <>stream H\n"1D|E/ED۾~yH,a Р,eeH خb{5:\|0}5ᴿO]'qq?^&Y56x=\^de8ԿUO?j}^sU]!Dž>w\Mu0~?^9F|\se!rȷn]'z|ͫz|'?k{=qGQ[RC;6Bjc=:p\N41 j]gI^+jxLM /C~Fk[c4 ː߮ .VǓߪ%Q6"ޭ:jD _P75ִ j.^vM G/KsvJsv{tB-О@<]Ƴpdv`vdv`v-5#dК2hBA d0 B!A `2j3d(P0CABfgz2{0{2{0{2{0{2{0{2{0{2{0{rzpzrzpzxfUoooooooooooo`VY2020fU`VYecVYfUdVYE2G0G2G0G2G0G2G0G2G0G2G0G2ohs"7Dl&Ɓ '6=$4>@$6>=O8qX%6-ơ5qh&6kƁ $6-ab*8qHlZzak ?xah ?ؚ¯c jiȯ)`nJCq4෵6džڌW55ڒ?Ʒc| ~mY|-oK3:C1u,t|8w|Pp wuq߇a\B[wrY`n1 endstream endobj 129 0 obj <>stream HlRkT>s!(Q$"UVWh]k&$ !%PgW H-HrYYXm֣-mWJw)m;8i9y/<ϼpaGv}h\)j&'KW5,sΏx!O9[=75=c_D3P@bw@]p|R@TO9A;p0[` <4x ~\(:npP uVXa/_yn9!A6m|BB(6vn`&ŮNv\̶HXL ;%d@Xhh8.`;6٤"jq1cCYJv.M%l`Qěؚ Hd;"f eeJX0K "f1.?ٚ]+a\IW`Y,g J%8-sqW[G_avcGGG '<3w~˵^'sc1iR"!'Cfrȴkn`=vm Vܳ߬qޝs:z:/]CgIg: 9Nͤy^ptz̓˨Ge<"7G=)w|(M(vg,N&=F w7o& zM(t:HUo0U6JUgc0T'Q䱆bke`5pӡlA|hڡ!2r)wz9|cmbz*&j \?qP0gyd;(| 3|&*!Zyt[yCNB?c[z!=xl@ I1+;Nj 1 )?[OM;k+Tg;k*98|+I7@/ӟf˘󟦎[;(:9^ ƒFџӺcV< HaɡDef_2[$P{9Yz6]h*;͔')/U̡ê%+.g;+J4Fѝѝi*yMW) ש6I=c̊;d,V&o O9LI^iHtSzܫ.&[C_gB VpDѿ@=',>;-O=KܔS3>w7#&H)-ZiYC/~EWb [>%H66(?-S,&S\ANw´VBIORUy#K8v"ߩƹWy>k7;CVw'~LBm4ۼص4Z<&n x ` '8`zw_scxŽ6Y5L5et4?(ty/Aֈ$&z悽t)K:K~lN3>UBh-H 렒l n~33 ӂ2T5!o:8#5e[!zsu%= 3 |BO>H D7ܼHExYS6$p͂¸!)pag| 㟻l!4ds'^T6Rr:L !9 mE5˳esEL8v+>NZ׊P8R!_ ; gm9!WLWpvX\YA$}8|2n?9V1̃g{+vj06㐢X:[C_h_6NF!y0D%[ía ՘iޣYC+q/~v?)ț%8< `(wGې]}F 6\,?Ft\ 82(NR^՟]ܳ"ʣZ~b:}/^6;z@u5n:02:3J`)ېVD^m~U*Mm#MFmt?'1$3F^lvR;O8Kf'w(SEgٺ@Xm('5]Rϖ ^Blȟ ! . 4t OeȀ |B8+8NdԓmY<4fMsIGӇ_.I Te01zH1IS4r^#4bQo_̨ҜX:NZ^fjٰ}qf]]U~a>벗XC}b1_AMewx3 hM{wenE`֎j ./D< I$/oވƘf;XPXlnK-bٮߥGgzpڎmtg:;{w|fg9R!ʐN2٭@[NJ p7`8 [ʹvjuV./䐨 VޙnQw79P7/B}9$RR% p:G]uA0SDq+?hzE8]qO8D%돦2«oBe];8A_5HK[J7iS=)i9#~SPk CW $!S gHȠQ 7L M`]B\#iy UQlmc+5,r(H氘>;qA;(oSɄce]tQjJ4-L6IvUƨk nr"O)gٗxC"uҦۤRK/MP22m RrZ"m|l+/z3iF`P)bb Md4g8:>^Mv;dQn͵Ʒ˭rS%`)Օ1X,5BUc0gclPއ&0Ixctk9I7n7Xn`E&^NIf^.鲨,Ymk)n'D>63<d> 0`M?v|,/Z `-A&gP :8` 25%]E( JX\X_O ."|y TB  WptL؉)G +!@hbU]rv)@d0#Q:ކȷ? ÆI8lW2B] Υ F1›= ,5NUMHb߀E$BGNƠȷ? 1c0>9|9ʁg!#۹ͣЅ[M<f[:zȑه e:q 8l RNY̐clu!KYFa4W(x5rGrR&2m]U<#S(;YƆo_@jz轄JzK:W)C;SdjZ4J|A:IX9}AfXJ <OH7A7"Q!@JEwv* S?+zF++< _'`Rl[C__VYg g,vө$/dmP%;k]C}zw9q(* RfN2 sN|ׄ,b/j%d6K 3w3޹|6K}45jULjI~f?7P0t}}jEzX9+L6 /ơ/^q. T4-3ȿBr H4l]ٽ>*v4C X6γ t^v>Šonb^c%Ey.ּ_je'lUh:zC K ~ΐ:mOaJ2jkϙ^:|~V^,z[ז>~xⱯޙK;3[{uҭP6Ҫzy#hqvu-ݖ\CmCkEWx e:*_M.6k dT<*z9D߀A[c)Ie`jEp0&#B^ &@)/ʦҲj5-t`"U~ēNKEe{PP?z}$+ n^/K(K@h(Eo.K6Xj]A!m*K}(X N*UaG눀w0t9B7/q="TgRez]W^p|pWrkT= =r7g<^!88!H3oa-vHdX VL  .`I2yetu@x0mtS!.v`5̙:lӟwI^cmzm `1'HEFMRFg0+ \悖.ȅ %;pu24UU`npzyHLbTcAvZ.䮹n9_pE atF8iOa)]jal8؁Mǫ]z ( 2"x @HPZ>|s~EfҥI0HS㧬X7ƅp6D'К(lfA7ƒHN%p"mfl|D5 obBf/oޏ`c6DYv!ZW {pZfc-ZH4`rHC(TkәR--ӟ:af8]s׍8ynbeoO>$ F]sgIOt frpHʨF\7$@3F RFOf(xL0"lU\g+r329N)-j+ Fpe0S2:Myb8V#OQJšb}'ᣆ(q:Ver*4!Q%M\8&\xz~3=7k7şd%4ɆXCpquIN>=seTHh2IpRT_h9~2y9V̜A/ѝ WwȂgCk9 !c1{4{_tt4!hp@lٞ￿ldf)$ @gw < [Z'bMžSM=ͶۃAtKOm-lp& ^7gph=, ??L![Y +I$)"_T<7yBNm^#/PZJ$pT" xU>wIb4q *+Rʘ"T⤌l:+H x04P0HYj:[AT*18I=e6ΫS#yFj1J#5tZybqbAIATAZ^jiCdXA8jR)pSϠF`B CtAjH 5<4ԏZK 5b!+ר^BsQ&A :I%h`fWm|GW<+1R:tZa[t`Y@N?ghk75_Z<|5@_xR"}I8ExC_n)͈<VKcCm"ZWw8]Ic3bĻcb5"%,3$^ mZEF!73_=)vM| v?~ b'y|8_u;#7C^'Z9@/]Q'٦O'w= rG|:Nί d~O.wgRCW;/0D_1Ƙ}MkT-'9hLp &6 pa;Fd瘦ڀB_>z|CdIC+=cl^D#w?/ߤT+wfYA<hl{OL~e~>"o?~;| ~3>1Gg}?#[woq߁^_ |Tynb>ƮY%WwNl8?7͛;o WOInKN9{݌=~W-pd`=e"?_ endstream endobj 92 0 obj <> endobj 93 0 obj <> endobj 123 0 obj [130 0 R 131 0 R 132 0 R 133 0 R 134 0 R 135 0 R 136 0 R 137 0 R 138 0 R 139 0 R 140 0 R 141 0 R 142 0 R 143 0 R 144 0 R 145 0 R 146 0 R 147 0 R 148 0 R 149 0 R 150 0 R 151 0 R 152 0 R 153 0 R] endobj 124 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\214\016\222\025\221\013\006\001\025 \007\220 \025\006)-10(\026)11(\013\r\007\205\026\216 \002\013\001\215 \221\002\205\024\025\203 \n\220\ \n\220 \221\025\006)-9.9(\007\016 \026\002\013\001\006\013\001\013\007\216\001\025\203 )]TJ 0 -1 TD [(\232\001\201\025\024\220\n\002\025\207\220\002\215\002\202\220\220 \025\026\ \n\002\020\026)11.1(\025\203? \(\006\220\006)-10(\026)11(\016\024\013\026\220\017\016\006\n\220\203 \025\f\222\025\002 \220\022\024\ \016\026)11(\013\013\001\013\007\220\222\))]TJ 39.202 1 Td [(Is it safe to leav)12.1(e r)31(ectal w)11(ound opened af)-31(ter tr)21(ansanal )]TJ -0.067 -1 Td [(micr)20(osur)31.1(ger)-31(y? A s)10.1(y)9.9(stematic r)31(e)11(vie)11(w and meta-analy)10.1(sis.)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0.01 Tc 0.349 Tw 10 0 0 10 42.5197 724.8299 Tm (\202\035\036\022\f\036\036\r \204\017\b\026\017\035 \200\035\026\007\017\ \n\017\030\024\r\017\004)Tj /Span<>> BDC ( )Tj EMC (\227 \007.\n.\027., \026\r\036)Tj 0 Tc 0 Tw (-)Tj 0.01 Tc 0.439 Tw 0 -1.218 TD [(\007\031\033\013\017\005 \024\021\007\036\035\024\n \024\027\022\024\023\ \030\024\022\021\024\035\024\020\017\017 \205\206\207\211 \253\203\204\222\ \037)10( )]TJ 0.377 Tw T* [(\022\024\035\024\023\030\024\022\021\024\035\024\020\017\017 \017\n\036\027\ \017 \202.\203. \217\t\032\017\b\273 \204\017\027\007\030\026\r\026)10( )]TJ 1.415 Tw T* [(\217\024\f\f\017\017, )0.5(\007\024\006\036\027\021 )0.5(\022\026\235\036\007\030\t )0.6(\022\024\035\024\023\030\024\022\021\024\035\024\020\017\017)10( )]TJ 0.479 Tw T* [(\205\206\207\210\211 \212\215\210 \217\204\202\203\215\210 \204\017\027\ \007\030\026\r\026 \217\024\f\f\017\017; ORCID)10( )]TJ -0.01 Tw T* (0000-0002-3399-0608)Tj 0 Tc 0.223 Tw 0 -1.218 TD (\221\017\027\017\006\t\027 \217\024\n\026\027 \025\024\027\f\021\026\027\ \021\017\027\024\r\017\004)Tj /Span<>> BDC ( )Tj EMC (\227 \026\f\023\017\030\026\027\021 \205\206\207\211 )Tj 0.864 Tw 0 -1.218 TD (\253\203\204\222\037 \022\024\035\024\023\030\024\022\021\024\035\024\020\ \017\017 \017\n\036\027\017 \202.\203. \217\t\032\017\b\273 )Tj 0 Tw T* (\204\017\027\007\030\026\r\026 \217\024\f\f\017\017)Tj /T1_2 1 Tf 0.023 Tw 23.244 9.742 Td (INFORMATION ABOUT THE AUTHORS \(ORCID\))Tj /T1_1 1 Tf 0 Tw T* [(R)11(oman K. S)-15.9(ini)-24(tsyn)]TJ T* [(Michael V. Alek)-9.9(seev)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0002-3399-0608)Tj T* [(S)15(t)15(anisl)-16(av V. Cher)-14.9(ny)-12.9(shov)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0002-6212-9454)Tj T* [(Eugeny G. R)-19.9(ybakov)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0002-3919-9067)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 42.5896 590.8719 Tm [(\r\031\024\034\033)48(\026)45(\024)-10(\223\033)48(\026/REFERENCES)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0 Tc 0.017 Tw 8 0 0 8 42.5197 578.0372 Tm (1.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (Buess)Tj /Span<>> BDC ( )Tj EMC [(G, Hut)-29.9(ter)-24(er)]TJ /Span<>> BDC ( )Tj EMC [(F, T)47(heiss)]TJ /Span<>> BDC ( )Tj EMC [(J, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. A sy)-13(stem for a tr)-33(ansanal end)-16(o)]TJ 0 Tw (-)Tj 0.023 Tw -1.296 -1.25 Td [(scopic r)-24(ec)-15.9(tum oper)-33(a)15(t)-32(ion. )]TJ /T1_4 1 Tf 0 Tw (Chirurg)Tj /T1_1 1 Tf 0.023 Tw (. 1984;55:677\22680. PMID: 6510078)Tj -0.003 Tw 0 -1.25 TD (2.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Heid)42(ar)-24(y)]TJ /Span<>> BDC ( )Tj EMC (B, Phang)Tj /Span<>> BDC ( )Tj EMC [(T, R)-10(av)-15(al)]TJ /Span<>> BDC ( )Tj EMC [(M, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. T)50(r)-33(ansanal )0.5(end)-16(oscopic micr)-32(osur)]TJ 0 Tw 25.99 0 Td (-)Tj -0.004 Tw -27.286 -1.25 Td [(ger)-24(y: )0.5(a r)-24(ev)-15.9(iew. )]TJ /T1_4 1 Tf [(Can )0.5(J Surg)]TJ /T1_1 1 Tf [(. 2014;57:127\22638. )0.5(PMID: )0.5(24666451 PMCID: )]TJ 0.023 Tw T* [(PMC3968206 d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1503/cjs.022412)Tj 0 0 0 1 k /GS1 gs 0.124 Tw T* (3.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Helew)-11.9(a)]TJ /Span<>> BDC ( )Tj EMC 3.265 0 Td [(RM, )0.5(R)-9.9(ajaee)]TJ /Span<>> BDC ( )Tj EMC 4.768 0 Td [(A)51(N, )0.6(R)-10(aiche)]TJ /Span<>> BDC ( )Tj EMC 4.692 0 Td [(I, )0.5(e)-11.9(t)]TJ /Span<>> BDC ( )Tj EMC 2.103 0 Td [(al. )0.5(T)47.1(he )0.5(im)10(plement)15.1(a)14.9(t)-31.9(ion )0.5(of )0.5(a )]TJ 0.221 Tw -16.124 -1.25 Td [(tr)-33(ansanal )0.6(end)-16(oscopic )0.6(micr)-32(osur)-31.9(ger)-24(y )0.6(p)25(r)-32(o)-16(gr)-33(amme: )0.6(ini)-24(t)-32(ial )0.6(e)-18(xper)-37(ience )]TJ 0.112 Tw T* [(wi)-24(t)-12.9(h sur)-32(gical per)-24(for)-15.9(mance. )]TJ /T1_4 1 Tf (Colorectal Dis)Tj /T1_1 1 Tf (. 2016;18:1057\22662. PMID: )Tj 0.023 Tw T* [(26990716 d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1111/codi.13333)Tj 0 0 0 1 k /GS1 gs 0.153 Tw T* (4.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Br)-32(o)-14(wn)]TJ /Span<>> BDC ( )Tj EMC [(CJ, R)-10(av)-15(al)]TJ /Span<>> BDC ( )Tj EMC [(MJ. A)15.1(d)-17(v)-15(ances in minimall)35(y inv)-15(asi)-16(ve sur)-32(ger)-23.9(y in )]TJ 0.052 Tw -1.296 -1.25 Td [(t)-13(he tr)-24(ea)15(tment of col)30(or)-24(ec)-16(t)15(al cancer. )]TJ /T1_4 1 Tf [(Exper)-40(t R)21(ev Anticancer Ther.)]TJ /T1_1 1 Tf ( 2008 )Tj 0.023 Tw T* [(Jan8\(1\):111\22623. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1586/14737140.8.1.111)Tj 0 0 0 1 k /GS1 gs 0.023 Tw ( PMID: 18095888.)Tj 0.228 Tw T* (5.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(R)-10(amir)-23.9(ez)]TJ /Span<>> BDC ( )Tj EMC [(JM, A)-25(guilell)-15.9(a)]TJ /Span<>> BDC ( )Tj EMC [(V, Ar)-24(r)-36.9(ibas)]TJ /Span<>> BDC ( )Tj EMC [(D, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. T)49.9(r)-32.9(ansanal full-t)-13(hick)]TJ 0 Tw 25.99 0 Td (-)Tj 0.18 Tw -27.286 -1.25 Td [(ness e)-18(x)-13(c)-23.9(ision of r)-23.9(ec)-16(t)15(al tumour)-10(s: should t)-13(he defec)-16(t be sutur)-24(ed? A )]TJ 0.233 Tw T* [(r)-33(and)-16(omized contr)-31.9(olled tr)-37(ial. )]TJ /T1_4 1 Tf (Colorectal Dis)Tj /T1_1 1 Tf (. 2002 Jan;4\(1\):51\22655. )Tj 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1046/j.1463-1318.2002.00293.x)Tj 0 0 0 1 k /GS1 gs 0.023 Tw ( PMID: 12780656.)Tj 0.008 Tc 0.349 Tw -1.847 -1.25 Td (6.)Tj /Span<>> BDC ( )Tj EMC 1.319 0 Td [(N)-13.7(our)-32.7(a)]TJ /Span<>> BDC ( )Tj EMC (S, Ohue)Tj /Span<>> BDC ( )Tj EMC (M, Miyoshi)Tj /Span<>> BDC ( )Tj EMC [(N, e)-11.7(t)]TJ /Span<>> BDC ( )Tj EMC [(al. S)-15.7(ignif)-27.7(icance of defec)-15.7(t)8( )]TJ 0 Tc 0.345 Tw -1.319 -1.25 Td [(cl)30(osur)-23.9(e )0.5(foll)30(o)-14(wing )0.6(tr)-33(ansanal )0.6(l)30(o)-16(cal )0.6(full-t)-13(hickness )0.6(e)-18(x)-12.9(c)-24(ision )0.5(of )0.6(r)-24(ec)]TJ 0 Tw (-)Tj 0.007 Tc 0.35 Tw T* [(t)14.8(al mal)-31.2(ignant tumor)-10.2(s. )]TJ /T1_4 1 Tf (Mol Clin Oncol)Tj /T1_1 1 Tf [(. 2016 O)-16.2(c)-16.2(t;5\(4\):449\226454.)7( )]TJ 0 Tc 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 2.088 0 Td (10.3892/mco.2016.979)Tj 0 0 0 1 k /GS1 gs 0.264 Tw [( Epub 2016 A)10(ug 4. PMID: 27699041; )]TJ 0.023 Tw -2.088 -1.25 Td (PMCID: PMC5038448.)Tj -0.032 Tw T* (7.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Al)56(t)15(af)]TJ /Span<>> BDC ( )Tj EMC 2.073 0 Td [(K, S)-15.9(l)-16(a)10(wik)]TJ /Span<>> BDC ( )Tj EMC [(S, )0.5(S)-16(o)-16(chor)-32(ov)-15(a)]TJ /Span<>> BDC ( )Tj EMC 8.936 0 Td [(D, e)-11.9(t)]TJ /Span<>> BDC ( )Tj EMC 1.973 0 Td [(al. )0.5(Mer)-10(se)-11(y)-13(side )0.5(Ear)-30(l)35(y )0.5(R)13(ec)-16(t)15(al Cancer )]TJ 0.167 Tw -14.278 -1.25 Td [(Ne)-12(t)-32(w)-13.9(or)-24(k. )0.5(L)35(ong-ter)-16(m )0.5(outcomes )0.5(of )0.5(open )0.5(ver)-9.9(sus )0.5(cl)30(osed )0.5(r)-24(ec)-16(t)15(al )0.5(defec)-15.9(t )]TJ 0.04 Tw T* [(af)-28(ter tr)-33(ansanal end)-15.9(oscopic micr)-31.9(oscopic sur)-32(ger)-24(y. )]TJ /T1_4 1 Tf (Colorectal Dis.)Tj /T1_1 1 Tf ( 2021 )Tj -0.035 Tw T* [(N)-14(ov;23\(11\):2904\2262910. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1111/codi.15830)Tj 0 0 0 1 k /GS1 gs -0.035 Tw [( Epub 2021 A)10(ug 14. )]TJ 0.023 Tw T* (PMID: 34288314.)Tj 0.319 Tw T* (8.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Hahnl)30(oser)]TJ /Span<>> BDC ( )Tj EMC [(D, Canter)-31.9(o)]TJ /Span<>> BDC ( )Tj EMC [(R, Sal)16(gad)-16(o)]TJ /Span<>> BDC ( )Tj EMC [(G, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. T)50(r)-33(ansanal minimal )]TJ 0.241 Tw -1.296 -1.25 Td [(inv)-15(asi)-15.9(ve sur)-31.9(ger)-24(y for r)-24(ec)-16(t)15(al lesions: should t)-13(he defec)-16(t be cl)30(osed? )]TJ /T1_4 1 Tf 0.207 Tw T* (Colorectal Dis)Tj /T1_1 1 Tf [(. 2015 Ma)15(y;17\(5\):397\226402. d)-15.9(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1111/codi.12866)Tj 0 0 0 1 k /GS1 gs ( )Tj 0.023 Tw -0 -1.25 Td (PMID: 25512176.)Tj 0.148 Tw T* (9.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Br)-32(o)-14(wn)]TJ /Span<>> BDC ( )Tj EMC [(CJ, Ho)-16(chman)]TJ /Span<>> BDC ( )Tj EMC [(D, R)-10(av)-15(al)]TJ /Span<>> BDC ( )Tj EMC [(MJ, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. A mul)56(t)-32(i-centr)-23.9(e r)-33(and)-16(om)]TJ 0 Tw (-)Tj 0.195 Tw -1.296 -1.25 Td [(ized contr)-32(olled tr)-37(ial of open vs cl)30(osed mana)-17(gement of t)-13(he r)-24(ec)-16(t)15.1(al )]TJ 0.039 Tw T* [(defec)-16(t af)-27.9(ter tr)-33(ansanal end)-16(oscopic )0.5(micr)-32(osur)-32(ger)-23.9(y. )]TJ /T1_4 1 Tf [(Colorectal )0.5(Dis)]TJ /T1_1 1 Tf (. 2019 )Tj 0.08 Tw T* [(Sep;21\(9\):1025\2261031. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1111/codi.14689)Tj 0 0 0 1 k /GS1 gs 0.08 Tw ( Epub 2019 Jun 11. )Tj 0.023 Tw T* (PMID: 31081281.)Tj 0.271 Tw T* (10.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(R)-10(amkumar)]TJ /Span<>> BDC ( )Tj EMC [(J, L)35(e)-12(t)15(ar)-22(te)]TJ /Span<>> BDC ( )Tj EMC [(F, K)-16(ar)-37(imuddin)]TJ /Span<>> BDC ( )Tj EMC [(AA, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Assessing t)-13(he )]TJ 0.128 Tw -1.796 -1.25 Td [(safe)-12(t)-10(y )0.6(and )0.6(outcomes )0.6(of )0.5(r)-24(epea)15.1(t )0.5(tr)-33(ansanal )0.5(end)-15.9(oscopic )0.5(micr)-31.9(osur)-32(ger)-24(y. )]TJ /T1_4 1 Tf 0.023 Tw T* (Surg Endosc.)Tj /T1_1 1 Tf [( 2019 Jun;33\(6\):1976\2261980. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1007/s00464-018-)Tj T* (6501-9)Tj 0 0 0 1 k /GS1 gs 0.023 Tw [( Epub 2019 F)10(eb 11. PMID: 30746573.)]TJ 0.277 Tw T* (11.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Khan)Tj /Span<>> BDC ( )Tj EMC (K, Hunter)Tj /Span<>> BDC ( )Tj EMC [(IA, Manzo)-16(or)]TJ /Span<>> BDC ( )Tj EMC [(T. S)-16(hould t)-12.9(he r)-23.9(ec)-16(t)15(al defec)-16(t be )]TJ 0.33 Tw -1.796 -1.25 Td [(sutur)-23.9(ed foll)30.1(o)-14(wing TEMS/T)35.1(AMIS car)-23.9(r)-37(ied out for neopl)-16(ast)-31.9(ic r)-23.9(ec)-16(t)15(al )]TJ -0.027 Tw T* [(lesions? A me)-12(t)15(a-anal)35(y)-13(sis. )]TJ /T1_4 1 Tf [(Ann R Coll Surg Eng)13(l)]TJ /T1_1 1 Tf [(. 2020 N)-14(ov;102\(9\):647\226)]TJ 0.346 Tw T* [(653. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw [(10.1308/r)-32(csann.2020.0135)]TJ 0 0 0 1 k /GS1 gs 0.346 Tw ( Epub 2020 Jun 15. PMID: )Tj 0.023 Tw T* (32538129; PMCID: PMC7591598.)Tj 0.124 Tw T* (12.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Menahem)Tj /Span<>> BDC ( )Tj EMC [(B, )0.5(Al)30(ves)]TJ /Span<>> BDC ( )Tj EMC 7.707 0 Td [(A, M)-23.9(or)-24(ell)30(o)]TJ /Span<>> BDC ( )Tj EMC 4.437 0 Td [(R, e)-11.9(t)]TJ /Span<>> BDC ( )Tj EMC 2.256 0 Td [(al. S)-15.9(hould t)-13(he )0.5(r)-24(ec)-16(t)15(al )0.5(defec)-16(t )]TJ 0.006 Tc 0.349 Tw 12.859 55 Td [(b)0.6(e)0.5( c)0.5(l)30.6(o)0.5(s)0.6(e)0.5(d)0.6( f)0.5(o)0.6(l)0.5(l)30.6(o)-13.5(w)0.6(i)0.5(n)0.6(g)0.5( t)0.6(r)-32.5(a)0.6(n)0.5(s)0.6(a)0.5(n)0.6(a)0.5(l)0.6( l)30.5(o)-15.4(c)0.5(a)0.6(l)0.6( e)-17.4(x)-12.4(c)-23.5(i)0.6(s)0.5(i)0.6(o)0.5(n)0.6( o)0.5(f)0.6( r)-23.4(e)0.6(c)-15.5(t)15.6(a)0.5(l)0.6( t)0.5(u)0.6(m)0.5(o)0.6(r)-9.5(s)0.6(?)6( )]TJ 0.35 Tw T* [(A sy)-13.4(stema)14.6(t)-32.4(ic r)-24.4(ev)-16.4(iew and me)-12.4(t)14.6(a-anal)34.6(y)-13.4(sis. )]TJ /T1_4 1 Tf [(T)53.6(ech Colop)45.6(roctol)]TJ /T1_1 1 Tf [(. 2017)6.1( )]TJ 0 Tc 0.192 Tw T* [(Dec;21\(12\):929\226936. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1007/s10151-017-1714-9)Tj 0 0 0 1 k /GS1 gs 0.192 Tw ( Epub 2017 )Tj 0.023 Tw T* [(N)-14(ov 13. PMID: 29134387.)]TJ 0.123 Tw T* (13.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Co)-16(co)]TJ /Span<>> BDC ( )Tj EMC [(C, R)-24(iz)-23.9(zo)]TJ /Span<>> BDC ( )Tj EMC [(G, Ma)15(t)-30(t)15(ana)]TJ /Span<>> BDC ( )Tj EMC [(C, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. T)50(r)-33(ansanal end)-16(oscopic micr)-32(o)]TJ 0 Tw (-)Tj 0.151 Tw -1.796 -1.25 Td [(sur)-32(ger)-23.9(y af)-27.9(ter neoad)17.1(juv)-15(ant )0.5(r)-33(adio)-16(chemo)17(t)-12.9(her)-33(apy )0.5(for )0.5(l)30(o)-16(call)35(y )0.5(ad)-17(v)-15(anced )]TJ 0.19 Tw T* [(e)-18(xtr)-32.9(aper)-37(i)-24(t)17(oneal r)-24(ec)-16(t)15(al cancer: shor)-22(t-ter)-15.9(m mor)-23.9(bidi)-24(t)-10(y and func)-15.9(t)-32(ion)]TJ 0 Tw (-)Tj 0.236 Tw T* (al outcome. )Tj /T1_4 1 Tf (Surg Endosc)Tj /T1_1 1 Tf [(. 2013 A)10(ug;27\(8\):2860\2267. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1007/)Tj T* (s00464-013-2842-6)Tj 0 0 0 1 k /GS1 gs 0.023 Tw [( Epub 2013 F)10(eb 13. PMID: 23404153.)]TJ -0.018 Tw T* (14.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(K)25(umar)]TJ /Span<>> BDC ( )Tj EMC [(A)35(S, Cor)-33(al)-30.9(ic)]TJ /Span<>> BDC ( )Tj EMC [(J, K)25(elleher)]TJ /Span<>> BDC ( )Tj EMC [(DC, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Com)10(pl)-30.9(ica)15(t)-32(ions of tr)-33(ansanal )]TJ 0.133 Tw -1.796 -1.25 Td [(end)-16(oscopic micr)-32(osur)-31.9(ger)-24(y ar)-23.9(e r)-33(ar)-23.9(e and minor: a single inst)-32(i)-24(tut)-31.9(ion\245s )]TJ 0.182 Tw T* [(anal)35(y)-13(sis )0.6(and )0.6(com)10(p)32(ar)-37(ison )0.6(t)17(o )0.5(e)-18(xist)-31.9(ing )0.5(d)42(a)15(t)15(a. )]TJ /T1_4 1 Tf 17.889 0 Td [(Dis )0.6(Colon )0.6(R)21(ectum)]TJ /T1_1 1 Tf [(. )0.6(2013 )]TJ 0.007 Tc 0.349 Tw -17.889 -1.25 Td [(Mar;56\(3\):295\226300. d)-15.8(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs -0.007 Tw (10.1097/DCR.0b013e31827163f7)Tj 0 0 0 1 k /GS1 gs 0.349 Tw [( PMID:)7( )]TJ 0 Tc 0 Tw T* (23392142.)Tj 0.06 Tw T* (15.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Mar)-32(ques)]TJ /Span<>> BDC ( )Tj EMC (CF, Nahas)Tj /Span<>> BDC ( )Tj EMC [(CS, R)-24(ibeir)-31.9(o U Jr, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. P)10(ost)17.1(oper)-33(a)15(t)-32(i)-16(ve com)10(pl)-30.9(i)]TJ 0 Tw (-)Tj 0.02 Tw -1.796 -1.25 Td [(ca)15(t)-32(ions )0.6(in )0.5(t)-13(he )0.6(tr)-24(ea)15(tment )0.6(of )0.6(r)-24(ec)-16(t)15(al )0.6(neopl)-16(asia )0.6(b)11.9(y )0.6(tr)-33(ansanal )0.6(end)-16(oscopic )]TJ -0.015 Tw T* [(micr)-32(osur)-31.9(ger)-24(y: a p)25(r)-32(ospec)-16(t)-32(i)-16(ve stud)17(y of r)-37(isk f)16(a)-17(c)-16(t)17(or)-10(s and t)-32(ime cour)-10(se. )]TJ /T1_4 1 Tf 0 Tw (Int )Tj 0.083 Tw T* (J Colorectal Dis.)Tj /T1_1 1 Tf [( 2016 Ap)25(r;31\(4\):833\22641. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1007/s00384-016-)Tj T* (2527-4)Tj 0 0 0 1 k /GS1 gs 0.023 Tw [( Epub 2016 F)10(eb 9. PMID: 26861635.)]TJ -0.024 Tw T* (16.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(L)35(ee)]TJ /Span<>> BDC ( )Tj EMC [(L, Al)56(t)-13(hof)-56(f)]TJ /Span<>> BDC ( )Tj EMC [(A, Ed)-17(w)-12(ar)-24(ds)]TJ /Span<>> BDC ( )Tj EMC [(K, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Outcomes of Cl)30(osed V)30(er)-10(sus Open )]TJ -0.081 Tw -1.796 -1.25 Td [(Defec)-16(ts Af)-28(ter L)34.9(o)-15.9(cal E)35(x)-13(c)-23.9(ision of R)13(ec)-16(t)15(al Neopl)-16(as)26(ms: A Mul)56(t)-32(i-inst)-31.9(i)-24(tut)-32(ional )]TJ 0.01 Tc 0.356 Tw T* [(M)0.5(a)15.5(t)0.5(ch)0.5(e)0.5(d)0.5( An)0.5(a)0.5(l)35.5(y)-12.5(s)0.5(is)0.5(.)0.5( )]TJ /T1_4 1 Tf [(D)0.5(i)0.5(s C)0.5(o)0.5(l)0.5(o)0.5(n R)21.5(e)0.5(c)0.5(t)0.5(um)]TJ /T1_1 1 Tf 15.852 0 Td [(.)0.5( 20)0.5(1)0.5(8)0.5( F)10.4(e)0.5(b)0.5(;)0.5(61)0.5(\()0.5(2)0.5(\))0.5(:1)0.5(7)0.5(2)0.5(\226)0.5(17)0.5(8)0.5(.)10( )]TJ 0 Tc 0 Tw -15.852 -1.25 Td [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1097/DCR.0000000000000962)Tj 0 0 0 1 k /GS1 gs 0.023 Tw ( PMID: 29337771.)Tj 0.223 Tw -1.847 -1.25 Td (17.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Br)-32(o)-14(wn)]TJ /Span<>> BDC ( )Tj EMC (CJ, Gentles)Tj /Span<>> BDC ( )Tj EMC (JQ, Phang)Tj /Span<>> BDC ( )Tj EMC [(TP, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. T)50(r)-33(ansanal end)-16(oscopic )]TJ 0.056 Tw -1.796 -1.25 Td [(micr)-32(osur)-31.9(ger)-24(y )0.5(as )0.6(d)42(a)15(y )0.5(sur)-32(ger)-23.9(y)]TJ /Span<>> BDC ( )Tj EMC 11.651 0 Td [(\227 )0.5(a )0.6(single-centr)-23.9(e )0.5(e)-18(xper)-37(ience )0.6(wi)-24(t)-12.9(h )0.5(500 )]TJ 0 Tw -11.651 -1.25 Td [(p)32(a)15(t)-32(ients. )]TJ /T1_4 1 Tf 0.081 Tw 3.918 0 Td (Colorectal Dis)Tj /T1_1 1 Tf [(. 2018 O)-15.9(c)-16(t;20\(10\):O310-O315. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1111/)Tj -3.918 -1.25 Td (codi.14337)Tj 0 0 0 1 k /GS1 gs 0.023 Tw [( Epub 2018 A)10(ug 24. PMID: 29992737.)]TJ -0.022 Tw T* (18.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Ar)-33(aujo)]TJ /Span<>> BDC ( )Tj EMC [(RO, V)25(al)-16(ad\343o)]TJ /Span<>> BDC ( )Tj EMC [(M, Bor)-32(ges)]TJ /Span<>> BDC ( )Tj EMC [(D, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. N)-14(onoper)-32.9(a)15(t)-32(i)-16(ve mana)-17(gement )]TJ 0.221 Tw -1.796 -1.25 Td [(of r)-24(ec)-15.9(t)15(al cancer af)-28(ter chemor)-32.9(adia)15(t)-32(ion opposed t)17(o r)-23.9(esec)-16(t)-32(ion af)-28(ter )]TJ 0.118 Tw T* [(com)10(ple)-12(te cl)-31(inical r)-23.9(esponse. A com)10(p)32(ar)-33(a)15(t)-32(i)-16(ve stud)17.1(y. )]TJ /T1_4 1 Tf (Eur J Surg Oncol.)Tj /T1_1 1 Tf 0 Tw ( )Tj 0.257 Tw T* [(2015 N)-14(ov;41\(11\):1456\22663. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1016/j.ejso.2015.08.156)Tj 0 0 0 1 k /GS1 gs 0.257 Tw ( Epub )Tj 0.023 Tw T* [(2015 A)10(ug 29. PMID: 26362228.)]TJ -0.037 Tw T* (19.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (\216\024\n\016\022\024\r)Tj /Span<>> BDC ( )Tj EMC (\213.\202., \223\036\030\027\t\001\024\r)Tj /Span<>> BDC ( )Tj EMC (\221.\200., \217\t\002\026\022\024\r)Tj /Span<>> BDC ( )Tj EMC (\213.\206., \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. \217\036\031\035\034\021\026\021\t )Tj 0.019 Tc 0.672 Tw -1.796 -1.25 Td [(6)0.5(00)0.5( \021)0.5(\030\026)0.5(\027)0.5(\f\026)0.5(\027)0.5(\026\035)0.5(\034)0.5(\027\t)0.5(\b)0.5( \220)0.5(\027\007)0.5(\024)0.5(\f\022)0.5(\024\023)0.5(\017)0.5(\004)0.5(\036\f)0.5(\022)0.5(\017\b)0.5( \024)0.5(\023\036)0.5(\030)0.5(\026\006)0.5(\017)0.5(\005 \023\024)]TJ /Span<>> BDC 24.313 0 Td ( )Tj EMC [(\023)0.5(\024)0.5(\r\024)]TJ 0 Tc 0 Tw 2.973 0 Td (-)Tj 0.263 Tw -27.286 -1.25 Td [(\007\031 )0.5(\026\007\036\027\024\n )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 5.952 0 Td [(\026\007\036\027\024\022\026\030\006\017\027\024\n )0.5(\023\030\016\n\024\005 )0.6(\022\017\001\022\017. )]TJ /T1_4 1 Tf 0 Tw 13.944 0 Td (\222\n\023\n\033\032\n\013\024\n\023\n\202\025\002.)Tj /T1_1 1 Tf ( )Tj 0.005 Tc 0.35 Tw -19.896 -1.25 Td [(2019;18\(3\):20\22640. d)-16.2(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs -0.005 Tw (10.33878/2073-7556-2019-18-3-20-40)Tj 0 0 0 1 k /GS1 gs /T1_4 1 Tf 0 Tc 0.355 Tw ( / )Tj /T1_1 1 Tf 0.199 Tw T* [(Khomy)22(akov)]TJ /Span<>> BDC ( )Tj EMC [(E.A., Cher)-15(ny)-13(shov)]TJ /Span<>> BDC ( )Tj EMC [(S.V., R)-20(ybakov)]TJ /Span<>> BDC ( )Tj EMC [(E.G., e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. T)47(he r)-24(esul)56(ts )]TJ 0.349 Tw T* [(of 600 tr)-32.9(ansanal end)-16(oscopic sur)-32(ger)-37(ies of r)-24(ec)-16(t)15(al adenomas and )]TJ 0 Tw T* [(adeno)-16(car)-32(c)-23.9(inomas. )]TJ /T1_4 1 Tf 7.89 0 Td [(K)18(olop)46(roktologia)]TJ /T1_1 1 Tf 0.317 Tw (. 2019;18\(3\):20\22640. \(in Russ.\). )Tj 0 Tw -7.89 -1.25 Td [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.33878/2073-7556-2019-18-3-20-40)Tj 0 0 0 1 k /GS1 gs 0.043 Tw -1.847 -1.25 Td (20.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Rushfeld)17.1(t)]TJ /Span<>> BDC ( )Tj EMC [(CF, N)-14(or)-24(db\370)]TJ /Span<>> BDC ( )Tj EMC [(M, S)15(teigen)]TJ /Span<>> BDC ( )Tj EMC [(SE, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. End)-16(oscopic full-t)-12.9(hick)]TJ 0 Tw 25.49 0 Td (-)Tj 0.022 Tw -27.286 -1.25 Td [(ness dissec)-16(t)-32(ion \(EFTD\) in t)-12.9(he r)-24(ec)-16(tum: a case ser)-37(ies. )]TJ /T1_4 1 Tf [(T)54(ech Colop)46.1(roctol)]TJ /T1_1 1 Tf 0 Tw (. )Tj 0.164 Tw T* [(2022 )0.5(Mar;26\(3\):187\226193. )0.6(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw 12.924 0 Td (10.1007/s10151-021-02558-w)Tj 0 0 0 1 k /GS1 gs 0.164 Tw [( )0.5(Epub )]TJ 0.023 Tw -12.924 -1.25 Td (2021 Dec 28. PMID: 34964075; PMCID: PMC8857165.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 0 Tw 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\214)10(\211\036\033 \035\030\032\t\033)30(\b)42(\032)-21(\240\033\233)]TJ 57.136 0 Td (REVIEW)Tj /T1_5 1 Tf 25 0 0 25 505.577 56.0378 Tm (187)Tj ET endstream endobj 101 0 obj <>>>/Subtype/Form>>stream 1 0.68 0 0.12 k /GS0 gs 42.52 54.638 453.543 1.375 re f 42.52 52.257 453.543 1.375 re f 42.52 755.476 453.543 1.375 re f endstream endobj 97 0 obj <> endobj 108 0 obj <> endobj 104 0 obj <> endobj 95 0 obj <> endobj 98 0 obj <> endobj 166 0 obj <> endobj 167 0 obj <>stream H\j }ܽXaeK!=д$+4Fw&.[~2+seMGUcXqgZiڨp_'$e 8TEQ'=k[h$P^ r*Muiv|-![i4Fk(Z R]vxQ9Ih"N#Y93#GS9R,LۼaÔ+>stream HQoLuk2;6XKz7 7F7(2 zcGRŅ",mg3d #0uYfL#H\/}<4hmt*uR[OMjweKmE1ʞ(%QϽ ‰44bUtv,֋w(ؤ::w.KMܲ%9vMP%wSؙUPv! XOQ4;UO4<]E/hvh4kE%zXxX*։ݒb!dV ʨ?jOb+)fPC9^hkDAAH/:6ՏRW#g ǴJ~3!$ ɯ[ ^zM>V"æyQH@q!{O(0l\ƅ==g_:i5ѕ MjTH1g9G־ {|C$ւ\wdٮFGuAu#+FaZվoQXpeiJ` {Z6 KBK(*g9_OFu3KcsՈ'dT+ uBca®k< ^ofؔmTdM_MصpE1֒I!# ń:kA<| 95ǹ3 .$>+F8u86RE.!4ra's9$]m~M(;/dA2!>`a?IL?Hj` U~Tw9/|uqj|7l1;Py2%u>^ _ U]-> endobj 164 0 obj <> endobj 165 0 obj <>stream H\nIyL."BHM>i=1Z&H6;E/|kߦq54 o84Oy\8ߜ[db9O~x eqw,|Mͧty>/_0Ǘzwx[j4< qyxMp?>s~F|4]a:/n5~~x{Z1a]ڣtJGƓtbIgƋtAK^C[|\٠-fKLޡw{t7k"f# Pbvb*+i_+; ϳƿZtNh-fߡߣCA~ߡV-!8+xr -? PڻIvm{>h>uCˇV=> 1=[Ӗ^<}ͱr67ZgCF1;jm~AЏ|i~ 4_bNs\y 0qm endstream endobj 169 0 obj <>stream HT}TW3*EL($V`D(H4]*d23L>ޢtktYUqU]{mnOw=ukg'Zd*O4R1IKƞ{ Ylp, I b^R*cQ za-I،fdaz\Ep~pu$\$ac~ӍfbzLtX]ScP%G )e*71Q mjE,U[i65V^[j2֘旕Wk-:դF|y5ZYh5o7kWT&hf6Wqմ:Pojbn3Z+U2Ze)T+Xjf[-8a~Mn1|! (@ + l up]:^{>(6tkLiBT<"{ !B6|26clՌ?;Tzp1p5,噰ȰڰG'OZ4'o69})SʦSUFLx/TzejCdhdEèMiO UKsھџΈZkbb1gf5g֟bCbc;fS3 ˹/͘YB|r~{bn΢7Lj4 ("\d:eKʷũwU.Ң.>uK2 >ljnլ]!;s缿4x)k^Vra76+UR,9PEDB)nTMN.s6Р}";6j(󒪻d2)::{(]<jfWFuYiΑe"l?}[Uk&IRFGfJ;PHOV(Z /SU;+_*B,g8UB_h_5qXoD0C_)lZzj&^= Ⱥ%S'E(lB;"$=TGce t]Yp;]9BDw?6#)epEdMnGDE׌IiP$z.yʄumdGoN"q]?&Z*aks}krf˾L/hMS-S ;)DUr5"q0"aW*FGyӦ&V$@bykn`j.!q[(uOzӲ3pA)^R(k.զ>ܦ?n|tˡA{`+eȆF#?^h!*du 5C$rj|B%-Wp KoI'i zjDh|K-?%u@b{z'Tu_n=4d&[!%>(+`t4=1>dJ{@'8 !,@z`>{fQnwT.zj5Yy%wMD" 9P!$x+4)v,֫Ν-fJ9sJs5d݆\fܰF!/Wte9Zqp.lŀK;E{vfHUBCő, z+q р(1%߼*3ABJ+o Th m,ɳ}rb`^-$֭Cg:% E[Y6Kpd{rpr<| dBऊ]+(NZ p; ʧ۷1hܣȓ-Ș&Wl]k33 񹍜0ajA\c:.[fs 4UXr;ŭUQ?$fP usI'f[tG hoP=aAq茀]ST`7un0Ӟ 2iBe^@ix]8Ҳv3"/ڎc$NcT"`l&I߯TbPw*ֱFKH/ X*o*_m/Uucm82L5SEi B(&\bn`}ێ/. !`N `L[hI*)*m9D-RM+eDޏoΪL/@Q+Mfrdz">Y9|$3tC{! z\bx7x)ݧ_>IZdO%g9bҦdf8G0>S%gᇒP;ףjS#}wDլr&_  R Gɨ7[*Lju2celkt3hź!eFTXF!*@ Ŵ@@bgAnq4@:N_~$wɶAu;mdJ ՅES#٫ N[R{q n)xò|yFzv^$+ 5Y*T؝'*zDOhʃn~|Н&g `C…`=1zM5lr-]| jpyP*_Hxt[л꺦i4 5.HL8 >XW=sZUUvUU%]cGT5ĸP~eo|&* 9|)KV7^B_DՈ(7r6o*]>`5#mDWݰUKt {q|9yro#ݦ8rjԹBlpL<{i.lG4]`u"i*$1UaW4:N]|m[ϡF[ܼMɫc4<lq7/hMP. YqmJDJL+I4_>[^:f?Y}9x;R|6RcKedzq"i-/D:V9NEwfdb=`}W#ʟƇ>&WmԀ_N8W|<'~zpR`A.l#cIM(~0 S ~c6bM-yWd݇17I`\d qR]z?0\o>KQ_}'ܣ&cr:p RudAjTGd؉sh$4+>.iӀDR?WwDL!!E #Գ^9oxLjSTSaYo)E4eڱkv%8 HVGtݣPf}Oog8b2s8}&o׶R$°N(Ht #jtid*EsG1);jJOf?=ŌW$j"Ywa+ YqOyr0 ~E&/ʞ{a XyRB{8/Ϋkm沋y۟g~']D%0igDkZPS=Lq9 vWK8D %ϰ7SwCo~6`[І*pG3^iL^po+nJlM!;g5Oޖ83ٔQ4Ӹ# ؠ祐hPɆ,E6)!K=_5ܕlKQZn /z [Νi&^k=;44ƢHx\BljITm sJvG)56E$z-I"s{(A8^0^^(V&&<^LK֭}b2~yz YMbUX2>2))F`|ڄĹ_^o;qN2#/M0dZgΦ@߆oC*2Z¿)<ϖm-[n@ A*¢ȴNİFl1X*mMM` 0tW xJY+0dHIm(|!1 ʰX԰UI`˒hR BN q`+.V~c@X[d'M*(<(l  jXe!:P~?:쫦f4J:oq:(ge"7Ӧt6J1$Y7"8&F@PgS5 زV`j30Ȇ*k/f-]L \]_/jw'ofBiXNX 0doU6GcE(H$YFnL(r$lu[ЛL;(l<@{Tk(+)Es 5EJs!\d&G[joBT 6cȪqqkm›A?JJw$;2"A4PP*WJ zPBJ(("px)d zB4?LYb=a|sA/dc7O4뎏?2%HξaJM(Is4qJ \/@` %KjwiGvBn))6dLt=Ӿ5&L̴/{;)EamDd58T/}!#A hgJS'"EG7Y` C9߁9Kv5aN@Y\D*o&Ȩ$y"#p`-Zb LD`L! ,DV, 1IZr iSUߌ˟iUynC`j-q)9Y=-'ڂ~ y)>4.I|@/IÝA9n;ir&FMT$>ܠW"88SѪهHTtj{0ha 윀#ȱrDF*r!Sz0}ɱ+0BH(` z)+hE0.eĸQ, auU hZƘ`MZ95—3˫^S_p=\ ْuDE0uMwBY1tH)̨)$T{^^ C 'nyƴ.'R6¡Dd xN7bF;8X140FpC ry~+MNæC1pD=E¯1B'>Ts5պѕG^n+e >W~$Gc*oOם/Nd3y|-P՚0- F3#.^ fMHVY`ÌMNOkgaOpmrUm9T Ծ>H\J/9+L/DR5znC9rB0n%aiV۲#u'5k,YKЮmx)~|7H48U eG7Ŗ#(.OXgѤ}rYUO]J@Dϼs.jdBQr9C=ҪMh[Dj7G|q˓eZ5|A2S!CA8*7C~^"/9V[o*fY :~F T{ }. > |YQU␊5O߆ МIy;~ {}]S%#koͯ$Yܺqp4HUu 3Ѻ6ޙν"2`lGA :@,!$@6d}{w͛IxH +V#Qq:g LBli)s9}YXPB@ xr'AH.x4bSeIa+%r~-=-`s D3-,1*#FIYwdhdF4"[GN9{a*;TwN][UEW_" %{\f-A\5j#NdA&rzY dp7 ̂Po!0sc1y'ִBq_Aww!j?`[qLK(vbSΜ%vhˆ7gȿ{+V5'MTX "ڍi]~]ZVib9nZ 秲M/Jl᏶_9)C`hvf`cJUlM|}>8xh33kXa Cf >DtI\vvӺE HMT+5{eM|%{5ye<0=pla )=I)7g3m}F$ HHބЏ լ .__Gu|~"C R b_ϸ;܂[Xc1Q QFmJEis>~lð> s0B򎮣ܜxIriqrL9ΎtF3r38 ;n:~0~<Eb%!`K|6*DU~tEnoUH=JԀ{c'st."r8cMlONOjl`/P]0CBtKR4J# @3NCGd1| #0hԇk:9P+qN9 ;`la{~ڷvj$]0@d &4RpI&V qH T%/", yZή[T8cx<ر?}Da"pOJ6Vwb=B4%rɂ P&Sչ~pOc %0]?IX ^d5[tfRE.6V{AN3FQ0욋 "}D:4+1CU@8yUXU \ Jun5~TN4Z+s FXVaȷ. X=.gMy>X Uhd!_M-^Ua;zVؼ-DW|v}[w󵱆l<zɚ4" }E?1+Uk3\׎&Ҡ''5(̱ M:^qџWʙK#:0U9QڎS۱ή+x(CT@2C88C sGTc܃:0>1m"]:6bIcD;ZBq"E,r9+7Dkc &4f:-3А${Ι{{(g:m Pk3@y9c_ݐnd|pTr&Ȗsko vo9j>z|5rT-bazTws⩂rʷK~dAP*.@0qܶܦ Im3t` ߅I7Z8(uD `Ǔ)xȸ0x~{W|EH/jS PCt0(JkxTOuCv5a٭g0}j)xr %IKO)DG݁ȔhLڡ6t X>-Il9dQ脱3MR& ւ _Gl譽qR(o'V%Y 1 |':7t讽]KkO qoZ~nij:c*,MqEnLú6_Q"dtgt9@WWjuWlXaڬ˩1u}dm7iE>)%#7v@+(х8N$h7nv/:Fs;FMP=)N3#L+4G+RHk<bquYwkt™>ap2P,;q=A>/ǯ1=MDq+`&;i/L12hkԸ#Jr܌sxm,?H46Y9'ɺ%L1n,( r{rβg1qJ0[x+Ó"9ƎK$,Ѥ_E3)Ráг[j{nkț bVT'qpH9Cqʸ NWX C`0U F> i9t>YxqD,R2cB@oA-VνqD[y>Z/۴v ۩# G}J' ^q:OP .hcQ |g>-Xr ch=B=[w헡rѴձ UrX+5#1Q ½"bl#HސZRA2CCa SԡN5 ||%+ifuiH*tYD9 -*m L sGlgJN{ TJ8]e[KJ32ț0 .Q0ZUb3ۢ޽'Qއ Ëq3xO>G5b=V/yp䱮zu{X.zC9"8_˜Ff[I؟iv^,o%ZͦRs)W̪!B83kMl;2C,HJ=f!Cj~̝wf?\\|P,IQ[j^(0!wA^=qQySvңk}*Ѿ3>Hl9 U•ec kx͎nK ǹM+QH蔧=H`퐄(%2Ȋ)"Ug SjM4^E;P%¸bT::@S8i=A$z:DЬ}w<=1qcC#>5g2iiSx.U7Cx*!u-US%$d]d<ُO_O)#c.]_jzXs(66޼Eq\_}Op g7b4ةz[ Vv4~Gڭ/`k2`*T!*zw;L,Ǘɲܪ{+ξ\]/ +M{ERBtn5p)HyRޔ?р׸.EjB21H Ԡ xX`%K!N**B" F!M4ˑ$繍PBo`'QK9`sM0ARj>;.Z902vRVR~}bx1b9Y>,E,[#Fcd55W7 у73,m[ŭY6bWжPv2Gh;_ endstream endobj 160 0 obj <> endobj 161 0 obj <> endobj 162 0 obj <>stream H\Ko@ Cga !aZv!ː~]])03=_t]m~]Wsw>rx>'tܼ{NlVM_ãzj<~y8woӏW^|^i,i_r5m/xYgCo}'z|ͫf|';k{=~qW"a>j%hG z tN zA^6ZE管붆u NSsM&!A}C~s j[eoPߐߴ7 4 <1א~ ]'AVkk-5lF6Q\P]P^BѻoVP_sul  QO'ԸSGGNNq/u~]K oyt<!ΒGgFȣ&y>stream HdTyTSWlLւ@Bpv4KE(2, dARu\Q)İ((JU ""e\"Qǝg3 v&?zNN~~wt'!$$-20ap L`T G7Pyxv^x4E5'X&BPNA4BZQJ-J( $YÂ?FRd>P,R8ʩ:I )J)-RG EH$_C'"sxpP"dYSF{ԁH8*@f!B::z^EFɕR'uT?6â5jMA8G%NdfԙbuAZF8/`XI,XYTE'#qF&`{,pubn F WL, 1(۠Lt8vzK+h'@F:S|`U1 6q9˹ʹ)S .S]R]޻npzԐ{ds.\6Gy@1ANg5s ;]Ӱiit<ߌ_y==zzy5V#r]@8MXGޡޯ+w 7D"UZ|T>FE}|_X=cˌY~Tϼ;ìY':-2ۃi1I᷀S)[k YC.KjË򵪬LRbx]թX@Q ddgcMfjsGt Á7Lf^ik88KU D1pLHtWV2vY| nUf05&uC,΢6ζ^NNfZ& zvE`,V9&LxDNioNJ^U +{.1tL뷮u)ĚL'XXQ$/&kG,Z\L V'={+E$QΣőa$GqdGr2&6Gu6Gu$rgw":RҮH)ͤҖܻsO/JhllTJZ)d#\DSX&Cr= nQ{81~/4mH$懭&Cch{0{0G`u\-N zqU8k0){}q gf(V1T=r慫۠|?QiQ Dgl\2Aپgx ,$BW\_U}@)Y&[,,-CwN#,}U cP֜Pal} @#[E5$'=rWtpfqk&˧&έ$a` ٿ]RvkwvY@tԞU5kj8iøihԙe!7լ{n EZub@o10iW(]@ 7QP(FZUvv[:V:vaftvd&9wۺ.E=5h:0AɤMNLלʛkբR-Zw*J)cq E'̧$&8J Lk7M\64['kjC~Nc F6r@~tF45Q5/b\wXhTZOw14 n$y؃k~g1 ߫6y _0굪p\{Xgz}orxZ|KpzƟ(# giR: ,G25 #] ؀D~ ügeg#ԧ$N&->2)ڼ;]AΣ`Xn?u&VАZGP޳2e_{N5.[ڙSWdH)u)g5y-:=K+5ic.а끂FJyR#QQ/Gȍ[%Y=ޛ:l H2FK߬uCG@ |#chgϻ 1?3Ooi4K,v/ _8F|Z yH(3 Sh&N2]=4zk+Zܞ%u9J+@3yr=1Ww(=ٛPڰx,ys ڊjQmeG5th5KfЩ\%(5\OٟHPjS[HL69AO>Hg&ڥL"uQ8Z<(ҩoezG =YZF' ²e颬,*Nb⻏ vQe:DMKZXH64G{Eu^ ޻$Mֽ^QF1m+A_<ˣ HE% A",.1W\wT011`S;Xg]0ffM;;w=9ћBWoU;Q֜9F=)+"|KYqRh 6̸ &h9X3aeQeeQeaaQQa 4%*41Soogc 3V`D$48+m  C֒•x 4Y!|f̒ V'L?TA/89Edsy+l5_jO'7AlfJ }Nr4XENcӓ~Sb5ZY . ǿ>uP9oz5k:ǐH>B'rT j fo@,~j5W3Io w * EyUl鴤u262'ݲ/A#$60 os1}{Sf T\qTM|GEc\eb|r3) /#G ١eGPfq%aŮ>%򚳧+ΕFM^2x@`;XhG9]FLwA٘uv$UlhOlf?nlj>,L;* أ:HH `8UEF]\̀^Aza'f2WnI5%^Tgdh9V*68'eC32g6oxPb̐+7I3D5L?K:Pt`-2C Z!Ը^UeNJ.2F뵤[V nâ (U`!ZOU|FZg'7qUǤ+[et5uSPJ_{. }/,Qx'u] vwny9<`fXJ`7; 5j@wA,#6 r.V 7;~Wj΢i t ^ S@th!tc]Md)dXFE;lry⏎Z5P/Sv/(BbKO4*hp(:1fU0mu w@+a+r9^F]Z)\7:DI;C]ٕ. Q|`tjᚫZ.!D!;6˯FV(Zda7ŭI0H86"wupV5iDˮ%gZ|,C>q@4~v*HzN\6+ fkt)vLygIJ v:Hw's {bQDۑ*Ch{B̫e_X@5T`d)覭\xHֶ@E}hkru WJoG0NYW7W+jk.WtX'[odhip%_R!p&9:%I L%%4@=x&*fp4VFN}x zf/ )>g gSVZ=TٗQ.)l˱ܤ3tcH/:g>[i.$ۈ,y^]1}Y"& v)jlNWsu5J :$}IBpCn}|3W鶧sl=l8Z샹ocz(yTG! usCB3c!U~6SƸ1U; IJ cD77eĝZ#rɷŅ)vg#Y&9X<6w\K|'xpצ,x[KzP^eEvq`GݝBOx(BYxDAa0r 3(:a:fhnzV+V|m=Vnj+y{ǜ|6VpLE;]XkuFcj)kdZJ2M12CK|@fk,+\cޛf&g0rӘr,5goRje{qf0wb炙61i2Zgk;Cw涫[X[=: =|//,q|dDuM%ݽMm\5@w4,җ᷶5Zl'龴Ze_|i*VScԀk˫t^w5dhQG8,gԥu9lV]3`x[78Bb‰V-9I1ےlGs)Ə\p@/ڑJ >t2wz턳.SE T _nzvᭊjNZ9hgvk3.} OzBiljbtyEaƋ\V>{!27:QUh\~u~Jd`'x:MSFݮ抈[]7{;Wkכ[P zD}ʰUU8!)5$Jf>yfY_5ܸ"Dx@JH숬i%64Mf`;B$EGIxװ;Eƀ ",]5x()6%\%E\#YM5E@)KF!\tA~g+ Ljl."wUu$N[r'q{_}i̇J Atu^XϙՖX.73>e`-][ɻKoQ;8'8ފͦ.Yc_չGy'ل>pC' fC CoQXKg@u>=i1]!%6ۯG`7Ȱn/lPȹF/2{ʚ)Ls1L@Joʅ) 3pNI`1*w+*]Ih%J93 }ScYB@ة0v}t+V~/4foLsbI8}UG?OP)MQHrBTmr9$ JZ1Ż9MZjL2eT00"JץqZcnob;kF|G%O={$ʉ*9s#/S *Ќ WU[ļQT- ׷n\ةwƥ INֳ[ 3gTV6C־(XXp%$Q)h z_}&_}F UCrC6[! :0zZC5Y#I$Kޘ*|+ب 0 endstream endobj 157 0 obj <> endobj 158 0 obj <> endobj 159 0 obj <>stream H\n"1E|"%D XC@ M! ~|2HI.Ʈ:.f۟njurSSߍzyۢϴQݩMo{y]_o폗bxWr(+S?ֻG5߽ïr.M5jT]9@,{vT>e&L{uطeoehR-^rVup܏u˪hm9nhOxmdm tN+j ̵kP{Ɣ5`+hhkpj`l&BZ_kpjkE~hPF8djgj4kjPc/1Ե쬦І{{d6RcrvEs>qds`sdsds`sds`sds`sds`sds`sds`sds`sswqz:ӱG===================s +0W@\s ?0~@A&5 I@MkP$&5IDM"""""""""QHHH69uYN4 4,  B( %\4̡AHS&4J N 䒤$diĉr2dAd;'C<ę { '~74b|F3ŀ2bdeȓAc|51#׊s7S}t8GNVyAU`r豣 endstream endobj 171 0 obj <>stream HlS{PSW?7Q (p7 DJ !U]خ+D "`@  `#. 4lap# '95x`X$LebX>+*Jۉ5c{1fz> v ;]>ƃ w.gL*Γq2dqAΓq)Yə .%&p)R'㨥qJ 2'娥LZ @H:᠌f`>(+:VDҠ⠞|)86^_}//5wVW M Շ> + sK,89s- TG񣘨7?NuLQy1. S"lN~Ϗ2wj=#}e4!6ebA񤸤֤ N-xp,9'ٛOYrtQꢾً/,DYjIj_ZPz|E~}cU%{ɨscjU` cL'Szg[^4xiՅCU/kap ~I=xkw:6JCRT ,s dHXAr;EnpjNjgPD(EUT}Qno2PEM_oI'tRcu2>$CC u1: m 벫i$GrQtL1sKx-@R8U0QcP5n1YFfrn,vr0vVnzV-%@؞FIB dy<-y q큥, ኊʪkFShЛE?Lo#m=_n[s,zmMG  .m{ ?0*#eeR]F'`x.䳟o iLA! Wvzoo>pv}PR\H::B5Qwpjvz8F*=tyqrI |Gli)X0 01+}cNg~4-ia2Q쯥:]"=+J ݒk6X:k}\SNЇ{GWW< MVNhk BdP7>6;Jv.שvU4U-:s+!2[ͮXst<]}T.]KcLp/Ke3بVb3U#[,&c͈Md_EXBo~@$0N-nt{QUdUE5qZqk{ƾ}{|ӺZ^1ν&^7z_^ Ɠ" gU;7qLA| c~)TMǒ6g߿[ٳKyQ s^Cp{2l3mPrQQ~ƴ6NtXi$y& p?xʫ=(Kޫmܹ 7j(!nЈ AɨA c,޽{KA$| b*>&:m㻱 ́e5?{~w Dn>n VSRukpVn(smڍE]-Eԅk(~`aо)WC\ko,ʢלjOZz:f׵90 jYGhej\%Zm=RQ;Uˆ$GKX$8V%ރIk!%,AoěKkzC((>3p-c*"N;cÅn-D/ jE^Gi@ٳuTʘ:iC_\._ #,Pb&XK3XDJodǽEMQ|̈=cVӆ9Ytnurh0K\<$=Jo@hR)*9jPGq͢1;ͪ ~D|X:&܆+`[-B>7$6ËuANv;|Syͻ tC[z;uǻ҃ )d3Q_y"bYOj%ъDL4l AO5w y,zOeKZ"x%B36Y\ jOwmaeM Cx!Z@d(g3qpgni>|Zę|XGDg_m RZf1(';hi2=C\CWQh"ȗPBƑ{Iyɸ?OVjthĠ.?.Q 0G4(j& ö́}"ݩw|ĐyGBDZAjkg#m E#J |,AܱȂBe٫-M:HSr0%pp("h!G*&ɢ'DlJi0^=k|Tki%p L[QAWhHhU2 kH u:K_9v֏f}@RO4좙y,J8bZkɱ e\Pb+N;~(p s\:=M9֣˔o+EE+4"uUYݍKLʥ78 Y+qB U{ѻzچ쳰@~I!aƲ[#fEM|>-KzICi FcCS?o?|[ڷ_um\6ա8 ܶdB7xxi <>?s7Tw9q(Q$LW,pߤaGuW1t %EﶄX XG[mƨ樧E'mEVnh!RN@ϡ[Yu!??J3xXk m2ci5SbVŅ?NE _"Y` wJR(6?WypSd)SF)%>2ӔLIBbh(m)C8``!YjO۲ bn; W !G -i'uZO#3}T3c/$3  'b݉bʚFFi2=e.w9Z0 vn(; Z/X/άsD~0@_L5J}njbRho% %=(=<ԍV5SsQm$cTiZM5dEWJ?ݍNX0+iLM*Xhed:k- ,J""VBbH jaC{2t%' )7lFd4Qfsbg'zK *ȖLvWYe/a8}ç4kQ g<*C8GW,ϩֹbPbHV  >`CjSi@tGFc*au*F{D!*;L~2yu_WXQF>`v=F7sʓ̺"G7yr?>JAZ}ӋAuQQYsS[Jw>n 8hElfa犟J*9*\L?$902HhuTvvU>>ùh5"UWYIW<̅H8 jj죮D\“^|l,akg i,uƣqYh=z -GbmٌMLGs Q @MuM]}m'=I&*2pV܋vMNFpݓ _q>Y}6 -ŧ5wS7qRQtQP |̲_Fƽmt;CJ(0¨uRY'o+Y x߉SMޤ%Qy{BjXy2xe:Mrl?F QW5vrR&d穟HT-cs"#r2O]2f64~Q/R?' ~ 8GLRsu kPzl}C{*%`&kWO[/qy@YQ&L4kw&9999vwd=ʍ UhOHj=V!ym+o& NS@V peȆc4v iSUC7H%qrЦ򼆛Dz֖ͪfw"޲p*b #2Tҿ `-ݍڿLN%Y cSxOaw6Qo#ǒM7G{QrJ7oB-,o,*ɐpkIyċܫ$W#ywJe:+#d҈flX[nDmS _5Fxe(i-i0{ʰ%dl}; >= iT2yaڥKڬ,~r2rrҠū(ոgmĈ^M\hb!w1n~I;&7հWSI:_g+`G3_M\gٕpHZw0)ɐpImB9 SL9jsc$2,]vWu` ;4hI(%I)4.i7zhfOh<k}~3w 3,|>}~"cʷh3l dULcs*YwXrsp\tWt/"Iiv]hx)dvq CHxf U-1R2'  kN:[c]6z= d'+$pmq~vk;u~htͲE8]@r+Z}f|RHr ME?E:^+d@՘v{ S+oINfc%Oα?zT Ut[J׭#T rqz #(<Cp /0W > o.U~ڗ|8Y"=ȼze^=BT*y*ʿf{U";-BJ eb4Z7kBtXcCoG=ctmcgBX$AU*`ӄ„bNr)׻̊%VU0!`:yme0A|F!fCx}L7diqIZa34q{IDjS r\<;a "%8scspI싂% {)/=lgpqb]Njo1̾sw? q^bK7eƖ=$XTb@K,T-kիe'WьYz* )hn334샧5~w5s4_ӈy̖y)'uq-/A7y4A`Pynw>43#É2'Z`QlpBBv2?PF,D:dYy4/D4'UO,2f5}`Nf/915euHVԬA7115c4)𨄦G !Dbկd$Jƺjw6{)sbefGoG7O|P_nb<5MMa!fqa56R ur(5{\>Yytd)~;!0>›d PW881guEo$c&L)_q h8n'HR  Ɛ\a_' w5Rˀ>IFK'!6c>=!D+ ӫO ._~%Wm;/כ?s@hk{|}:BW첝6nq)`?1[vJV*U,4$(m#.3ɄHEp:M?>ׂ ,8LԳOvmS&.g;IIR3xxX򖽴 B& ~+)8z)[o/{ۏ﩯5qd#\*ŖS޷kkm&81lf'Ơ[_)ˍhr OA+E;N:"n ;W~1m]X@Pu6ޡUocVMǟeg@6fV?dMz)U24^GٸG'p?0&F>= t$ ΦO2$`!FTTWΟ`Zsf9F3 wj>--XlIPM:{ Yv~D7cgH@N'`(luBJl >3>}ƤsE8N|CI.A4Ƽ.zCX(H|iW@rkA X%`ؘH-Ckz_;/ޕz7wHb  z ƔߢҡQ%Ի#"sdϽ}֟0<Lo < ,Z!.2b{=qH'outS*IoH y]vǢՃz"(|VZOYu܃8^Խc%w{ԩN48ZM4"V#*˛}ܻO "bLMqRJlk1Kgzդ3ݝ׽{w@L}ݳۓmx#FW2Z2<(YΊAX oEu0nufnb)PmJNbo6g3w,I5WQ#Y5 !`Wx]+nhNL& [3t"2ĐZꎛ ,휨 ߔO>Q{~aH"9wȿD ׽[daSwyd׊i{t!>< Q_&ֻ=S;gբ=*hXPl798)T$I4_]{39}-{jS<%[ G <֏pg*")37 Tn,"nڲ<}Ft2%U,5ϙjVn3v^[rӁ~j-E "ׯiQ u6T,ѡbT\n|WkT/:`,f4^m~N}ϰgh9c\˻@n#rjB.9mҋA&fm9!ڲ\|i!:y[ bP^FjVk(6`Lۊjfm38ٍphL 1PF l5 xrG &TmfhR2>K=Rޝ e(^:<})BxRF!OM0{Tsim&(C%9ך,ٟԜ$%t#^,< k/$f8Cm\|vCyE1,GtXCaN vpD<qmHi:q5UYx?z[L66 "H}WM]H Ԙ;VĻ'3fÝ5',=7V=&&c6 x==]o]:8ud Z4FN\*(õD2`? yMRdf,fUwraUV}\t*AE:;kdIg4{ή_yxKEGɮ7bE(q+"K>BG 17kI?'5ӧ+%0;>8?w"Pite~GĚ8u0.T1 ^˱La8mxs ci eJxw,[&t܋#0l.xg-;@?L9;7I ܔPDzu$G1WA?:xZ atoЛ7] *xu;9aJ[zQW{?q; z .XJI' H SuGe%:%2]';: .Ebry4O\׉p3vpǹL- _\b͔yYNIDxD%wН|G"Id…$ ӮHeVqyH<A ZZo%A*+ u{ץ4mJmQ롾ߌpe[!5p1 ܠϙǩ'ֶ#J9[h4M6lvn5MҖZ̴zwܵ 1:9o3on^7 r37|XkDPH3ˢ+^$Rŵgu}?ׁ((E%Wdb&53|OЭoz%MOfi)h8a IQe>4DQi6ahp hKA/-i/O7U2jRXU7| @*%ӫc:p#FG^{||e*E_{u~0 hFfRكi5ܪ5GiZ~n"`PUGG(hW^MZ%>q9ÎRY:ǘ* ^Psb7P qXaq>_, =W_bxȆڧM_l kXy5/b 8>v,C%<-lA.+ܫu84N'!grwIAQ D֌@vW^| ­Ӂm93%\})Ҙ g-,2獾pJda)qn79_b\fϴcH7!U^wum1]ߜb &?g lk-OIaJ] wQtV'mϬq)zZ&P3ĩ+|g@us3z _{Y8wo{&6|.эJ*nVOr Z ZCUCX \_pZ] ͪ;@k7;||Wz9hXRPVv :j#NN53F2ޛ|6a|$39LOoIk3"?R$7E}wwa_>-J< O<0|ܑx{^%sKoY^,-0ux#Jb-5(5͐{|nZ$<]SDzp;OH&O&ܖ|&6!={vNh3g䢒|~W)0 ʌ!9\K#`r-M2 >D•0+y% __62IVLL֏ө.~xQtwܔ c+ V(4/EެO JZ--MuMT H/^ 7'3b",]?:ǩ&No2e m-i8 }=bd?E"qeߋf0 JT[}Ce`oܼ%^+O8&X= $'L78tA7QIbcQWj'. bF si"N7^`0mjjEsLY1p0<}@I5*~7qޟh Y'5`#Y=kDSO@kT 6QB zp<$MPY:P^M3}AMǁ$2,0|qR@Mh yy@ehqsk#(X§ o7Rv3bqJl:@[$N0>9 H~ I^knmVGh *wETլ<;kݳ*Cpa蟷utƬrܑHh99̹394y endstream endobj 154 0 obj <> endobj 155 0 obj <> endobj 156 0 obj <>stream H\n8~ g$l a}V2&8YHRWfqܛ4ݛ|^r2omΗӽ~ٮ>r<<4ۿ/g;_yZ.kfqަ޴nל5oǷrٷm]ߌ?oSct=OiZyhן]0?4i[{~9}?.|nϻU[jgI^s4t;Cg4=h4>Bit|S;h;5w ߵЕ]9^W_S×k#~E|i̷Q4"N^l/}^< _v'iȭ's4ډQ3N<;'~֏?ˉysg8\yN<_/f֏3gbf {1νy/Y^^̬m/fր3ċ10qpFEEEEEEEEEEEEEEEEEEEEEEvV;Wο6((3f$c ƒ%K2`,X$c ƒ%K2`,X$c ƒ%KbK`KamVS3`jj,fkSǬfPpYM͂3g558jjf556fVMcVS38fì&kS[?bR"~ ElL䳀߶/IlE)E^:i!34yKGJX ge!w`T:у+q0iփmg=hA<x 9 `t6 Ҁ Kr;sDQ #FvTix,냋<ƺwzkU+55. endstream endobj 172 0 obj <>stream HT{PSg>(`($r_PEVGF:nvoٝv޹sw;;@ 9i]eye҆Ekه-p8Uʎx\lq-fnT La 1@ @2H:`EMP v]GI\WMp <߃P0.K`,۠ҰO3~8GWp> h0iBx#/4 ״)Qk~$E5=4iVI8^5|-Z>@˳k=x%d*>Wx3F?gP|*x_'ZkQ|j/P.nO:>F _]3?R i e*ŕ_Uo?*{,6PgqSR:j.oܺY!Hsϳ0E] C;`NrUg޻.Yi+^x* }l:M]=wluNM;pMCG_U>kA-Z.[Q$E2C(XF1N=4pҴq#1* g<)ۻ{K6_^<$@cF$iRֺ6E\FX侶űt1걻=yHX Pg?rDϾ.! %"OFa2]<СQ܅`܅ q"^DuRN4tgb"%[MH !U\vueeFcWYwwWW7.gKGCdlF?wW;Rxgdj%Mw!ېnK$p/x[/ߚ>Vq1C<++QT'ON%j݉'Mgd ]dB pM,0V2ϚUbv )55W2At"x~7hxiԙa&/KX͚s$Q`ШFa0ȿTFCMFH %%. фmvvdpT1#vz Tp ˿T}:,ScTdyYJfۄ[fOdr.*x<ҭ{2ۛM{uC= #GYH\|,-ֽٕTO&!kK`W+1m'(%tSW9"eQO`OWODYT67ߺJfɌ ̡!;uq4&az§S'巑 Vu^|9d] 7dxAa-n==55+6jؚ؉cw ,c/(qC=PGqc~E:ebԓU]:gb@ךџ%N<8|ͭ}5?[|K(1mBżݹXzĽ{? !ㅷ9Ö&'7>wrkY͸0&,r0DI5TGE507% VWԷ[˿2r zXDAoex_.kl}N~pCE4d lrG`(]5[蒹c]KvcYt HB5-]4IaӎnQtXD0&Asi xU_4(\:jAC_|u%u> &n*OPL?Dru7$-xxX"!=!5Ddʹd<[GXd; x%6:a}b8AAnx9Mg¬M4Ui%o^09OI̹˧T %Ө61Gz?Uu/f;M`$gP,d.anFOkŷU[$+3XY<<Hd.i$K%[0)4<G\e2+՝j(@:t_X[ ̾=Okd *n}uZ߁]\a sO`G\ BsS% z-;"YpWWw/D@mdrqL-FBTa֟޶T<7)lBcDA6&/] *f7$5{9SӪ0Xe3ƛڧg d ]'h+sܾ Λ&%FZ;^g>@Z}ZX5ZDt()eAhc|ӵa]߹ڞ:͹dT\I!8s%v&θ!4S/D8M.>F8쎼4]|6`,=8ep7@>Se4K`$9?kVPla0!2WvjXؗ_5Ait(FvȨyvrK) o|p<8~ՠ]~VZ3Pʇg~z";fQkMc󴳳iz҅H_t }pj'Uy't)zdCvypd3  W\ˋ.I7%,IWZp)ܼ/DzDDY6eo3v[˥//(tw ܃8N n +Jd BZR[)SP!&$@$H,nvksw═ĄSHAC1P8)ҩZ;6-NOCݻs{s,.M uRg(t7PQkWRd"XƮ0I!}]-b|>^TD߿"i:=HO+Wù5f:.F|hS52*ַW#Gc+π"x}B!N&z a+x/9dYw''AG!<S Xs %>.f>:L]!;<eآe_itB?S? v g yRɪ+ڵYU-b'_o\]P 4Ixhn2ۘB|H#)<ʉqZ1hd$` ?Gf29zyi0+ԇcC3ز_3?#*SWLh\ H}"c.QŸK,ּ6KDT4{YBei4~dѴdA'}#<`c!'|!!3[O\.8Gq'>3/6]ζmw62\*4ds ,T7`zE1a:Ó;?0/}h7X@nc )6v'0LxHFM rPf`g`?Rwg^yHNXxo.A$Ji'k-!JN ?^bh4.z@PY3; (^dAEI"|d6[DR: 4Zg=J YByNlno6Yŭ,3ŒȴAl04)c#8Y2t:E(HV I/Ǟq!=Ϝ!T'Cș(M AL+Qe"`֙BSΫ^I܅$8ܹ8VF#ZSKP&I1h:>?&$|6&1(aږmFqvUn4\BjΈyk:PZx:oXE,PeqǗb36,sƓQuzG}i)E Ƞ#n:gE'<> ]xt 99$1hG/|Tq2oC #E<*ߊ'~G{9xX;M?cAgǚ)^+U3ć@;tehlOܱ^=t*&(-٩ymso_쬭e4M *Vn3Ԁv &1M6ThW홌st,((ZuH!7Ņ>QR&ޔU{.<$a ?weTp3%kwͫC;צW'>1 ԯӿ8QYmiMCQB`E 9=F;s[X^WayRd6}h-iԏ=]<5yhDީ34Aغ'QGpJkwa \ Y4?">}4L9hbw>RSC/ڸx pnJ`ui hjIo=S Koցy7ʙSgZ[ l~x!Հ?DV*h<yT8S_Wb{TJ+7] - ;NǙ3w>>!<#ME̅$5wF]&hi'9*IY"Gm>0~>rI|(8M$DYu*=vu̓sII[Hrch4/驟tj[g}*%I`Q3*P;Hۿ3'=򜱋}el{Jq:%28++xx;GI}C`0 }`2[6ekJ63kUIV=& (DːD6iy~WqtAspϠs ^lQ6Vi+BHKh6:OfC>O:#5f$AT+A$S8$ t/2TZy*Ů_y&tć:릪 u1 WP0`R6z*&{ tP}Ç˒š  `#`4E0=|'}Swuz _]%E̷Y_rwms6%+p7x5Ca@>p\lՠ N w O֔t).eMf&]Uv!:^6zM[sq2p!6ĝ 6_=X$ s|CQY/Qd4~~ħfckM*a~m$5dڄ u$iI*2+Jaxvrm[.p;"X )JS'Oc+L\b$J9_ %iĮ@Qk PBY*g6K"s*N? [Ma68 d܌oץ(U$7Cbj|/{ԝ:~4;l*9ɦb ;%zvsƟS>~|_%v.S0qv;n|wt|ˏ  k»9=_{SK$poroyOPQz£+ n3_AQWݥ157ޫ5$L3I'ꣾ@/T( }kUTQK1$!FcfX,4O;d&;s9{_b$EOz42Zc0UkR,a'IZKJ 1{)I36)n~I]ƂcOܮ#|ӛ_]9Rc&RCz;-oY d |.6xۧõǘPPud6<^נRMȯ mQtTQ^{e~ɪnc6 M/@"I.foPܻ$`h}$eQ=P,)2N>2 `zmf`hC L >%yߩ!K L%cBc籁9f L3±2|IRCSa? 1=O2%.”.3-mғӓPe]aտ4Ef] >4\;< Qv5&3K,*EMvݡ1M >_ DkqġX|SJJ 4 aط[e7DeyC8vhG0~~eŷer͋gU%$0x/'w1;eU9ײQ`q]TDR❫bQvHl]oY3^;ZPk>עKJʺFJUd X$t{=ߺN͘$l@Tty0#*w{YYX]ؘSreNJo)<7pNuY'4D'}wH6R4ad2Y~< ?:? }9*a*$f d:4'W?aQB|ŠҪ軱$Iv:|ϚlOZZ9MsuSQahoh@äcOT2Y +3PrQg4[؀/%'e/dWfTC}+MG c[;'@߂^6TTUUʪёU B)"+j s*s)esXwa+0 ;>,}Ñѽy~ MY&;Dk-0.Y<2UL]ڗth+κK7n61ӎ @C[1dNK'V?w#vC::*:6V yQԤ\eͶN?AQZZŔeMMk4Gv)^o?cB4cu`&<76 fz1B c|Q 9L#[#Wځ܊$1 8qJdWxY<{}71nу3e2\NtvZ e(TnCPPq*ʘ51q䇫48MԛtES[>Z ƣboB:ÁxAv:A-v|˦dd4@f²⯐o1efQejh>| qgUZv'|\Ȓ"?J>u ΁8*]>(0sT+K,6PΈ7e3&%Kt&*Gß:.#F(,HhQ"p@{fύs܁i7"SڱuY966Y2$ U^d|HUrA> (*)n#-K^B FKVd,: z@$^Tŋ?'dx%_J^Y(Lc-L{H:? 鮧|[czFIŗ1NuBz+ ;hr``l\]iq}Nb@/i}+{˓-%]hb}=<h"ryh-s1$'!17)=Sy氹rKfNK96Xxh603 Ӣ)7]xfӌ)oUK Vf'k v)|CVE}cJ7=GP\wɴmӯ u/0-?qoc&i$JJB# 8L>o42x|C' E4hiR"y;a& 7Fai @x9xڣ>|jrvEtXPCS_'+`SĠ+uQl/ fҋ$ޥ8hN ^N7-yTBs֮jµQz#t ƭ dz+n0fX~S:;MnvʬB14({8zFr L64xI<4nh;:8F|90Œ9.+_ 3Z诏f'\Q!9v8}5(=Ekwbhxܪl:Bd,r#,8Z.WnX ͈II;o6> htդğN] +Y_ouuO na;AԸPy: f/E'ͫ[|z <&AM<;N|샆~Ba7|3ҊU#(K cHpSoD~YR~k 4N4sM+P{VJ_eȠm9ݘo2iJ#m XGIEŤ:vaq t=>YBJ@Am&_-Ihc/eX7zX?Nvʧ 4hH^90ߚJ*cY5X~._yuR/r8TuVN181jf&Q/а. {. (XVF@J5ٚKQ`ژg7fЈC?t9}ߟ1&MI|?Cص,!J )̸1۟AjJ#8( 65ĚBOVOKeաur2W.Eʘ"Dj/*xɤv[0rD^ÈB}FN}{vO֬HF.[U3-D$%_ 3L Z~?P6=1ЋG![É`>la 1s&U,Jeq }-tip`)6g:3BZSWp\]+cDGR)e0_13$QLE9z>w/etmLzeލ8JDk^Bi*Fo|xq{]L۱SgM~'$( : P|3.D3Υ1 MCQMGBv{/漦d[,ٍ MǖƖKcv'`Ou^N !.zUoU\N$4ŁÔHQZ`Al%J`9go譼'%-3PGHL\Oi8>x̮wnc8D{WU]6kL\ڑ0 `0Gm`M#źM.ѡکՁvwVN\xY'HUxj؝^Up :AhX10kK/: Ŏ/Q2;.J%XQ‡]Z-1G!/ "zF=Z:r2Lb:LH`[߽v$tL[!·ð" X$ӉEHЯ&'$ 4|b܀\rQ5 ;v֣)jڄRTḀQ!8둲5njX[vTA)x.&W\b8EXȖ{MJ bH_ % K $t@ UE@i"FDWtU4ZkCoՍaԈ*PT7^ktM^!ނUd+dP at T08P~f М MxߧE>8돷vQm_<~F6{-," P3k D>Y?o>Ǵ6e-9LxF]u)N^;wԦRh syZSMtn^xE l¼̜m"b.Z0wedJ+4NBKfaDziLi֬u4 Kpї i =jpSATS_FT]`0 | $9Cᶴb3caf3葌=ht`; CxҽyELeO跜`I,K^atnٻMSE.(˂B9 UQU44BgL$Ϡ{{!1 _.l1`2Z orMFODA-~I`'BkiufԌf$mKKp0 e4I`Cb <,-deI+iJBXwn4.do_uTkTUs؃`I\<~Hɲ [[%8L'! (>h - I(jJT@n3 Va/f仈 o' / yrSTN\VɥʖuO\ 8ׯЉVU2ƐiO  8N|L]c8B=x0MPgI}#`0X0E'vv:PTYZ]VRwtR0QW`Xf 34mke͈ܨ̐ubJcypő`q"ư(d6Ss2V)5ˇ4#"Qoێ@XKzˮ9d~<'Ҝw[s[:߇yV{P2ϛޕY"rk>[K/qCO~B FN˂\nA&b0)W2fpfjnH#Yo{mI?W[hceљ a8)"dJA@s F(pE!NIMNZ Cc2>b\1\sYtwO 7&rhtG7 y"9  Mv@x\@'P1-M[0e!=Z2+,4Jrs ^O 18ߟJSv<ܼ v#_zPKmR>8GQmglU96cS\IHHX1ʆ=a:v]nHzD>)!; !L:l'Mv2Z~X')iEIG%;q~P^֕2FJ B1DT19ƫ`Ƥm8(c( :bt;h'F$Ec]Rؼla:BqXKC$BzdXrH `H`AqzCgm4߄f7ktƸkYzl.|g٪5"IBjOkfߤ.t.S2 D¼ԉSg͛KUoUmdIb!^nq~C:cR[m4jS&}ؽKsv՞͸DP9i ax/tNLmoـmwl3.'CQ.7m!pң ډ:RzxbY$D2v~wJ v8BAdP.`.i6i,` a͹ldd`_DV1֬nmCbv rw}儰Iڎ3~޵@ @t9ZZބZn]@rx*cnh#$:>vf;_*~fy,`mM+u⅝՟av'Bp<3C- ź;vDԉmյN3dex.O<- Ehev2*C[1Ua/#)ݑ; 0;^ᒄ;O%DT{z?l&>1BdohTL ׁƘg,3cbF"p_M1Ez9K-LH{~~b35c7b`Wyv3={#3d1;TvΕ y8yq垿uoH Q endstream endobj 130 0 obj <>/Border[0 0 0]/H/N/Rect[100.508 545.333 165.627 536.037]/Subtype/Link/Type/Annot>> endobj 131 0 obj <>/Border[0 0 0]/H/N/Rect[91.3481 505.333 157.356 496.037]/Subtype/Link/Type/Annot>> endobj 132 0 obj <>/Border[0 0 0]/H/N/Rect[113.916 475.333 202.931 466.037]/Subtype/Link/Type/Annot>> endobj 133 0 obj <>/Border[0 0 0]/H/N/Rect[57.2978 435.333 173.281 426.037]/Subtype/Link/Type/Annot>> endobj 134 0 obj <>/Border[0 0 0]/H/N/Rect[59.2269 395.333 135.138 386.037]/Subtype/Link/Type/Annot>> endobj 135 0 obj <>/Border[0 0 0]/H/N/Rect[136.386 345.333 202.393 336.037]/Subtype/Link/Type/Annot>> endobj 136 0 obj <>/Border[0 0 0]/H/N/Rect[197.614 305.333 263.622 295.877]/Subtype/Link/Type/Annot>> endobj 137 0 obj <>/Border[0 0 0]/H/N/Rect[133.303 255.333 199.311 246.037]/Subtype/Link/Type/Annot>> endobj 138 0 obj <>/Border[0 0 0]/H/N/Rect[192.966 215.333 263.622 205.877]/Subtype/Link/Type/Annot>> endobj 139 0 obj <>/Border[0 0 0]/H/N/Rect[42.5197 205.333 65.3356 196.037]/Subtype/Link/Type/Annot>> endobj 140 0 obj <>/Border[0 0 0]/H/N/Rect[78.884 165.333 166.923 156.037]/Subtype/Link/Type/Annot>> endobj 141 0 obj <>/Border[0 0 0]/H/N/Rect[363.764 565.333 457.235 556.037]/Subtype/Link/Type/Annot>> endobj 142 0 obj <>/Border[0 0 0]/H/N/Rect[466.151 515.333 496.063 505.877]/Subtype/Link/Type/Annot>> endobj 143 0 obj <>/Border[0 0 0]/H/N/Rect[274.961 505.333 338.52 496.037]/Subtype/Link/Type/Annot>> endobj 144 0 obj <>/Border[0 0 0]/H/N/Rect[363.455 465.333 471.902 456.037]/Subtype/Link/Type/Annot>> endobj 145 0 obj <>/Border[0 0 0]/H/N/Rect[425.407 415.333 496.063 405.877]/Subtype/Link/Type/Annot>> endobj 146 0 obj <>/Border[0 0 0]/H/N/Rect[274.961 405.333 297.777 396.037]/Subtype/Link/Type/Annot>> endobj 147 0 obj <>/Border[0 0 0]/H/N/Rect[289.739 365.333 398.418 356.037]/Subtype/Link/Type/Annot>> endobj 148 0 obj <>/Border[0 0 0]/H/N/Rect[466.151 335.333 496.063 325.877]/Subtype/Link/Type/Annot>> endobj 149 0 obj <>/Border[0 0 0]/H/N/Rect[274.961 325.333 311.056 316.037]/Subtype/Link/Type/Annot>> endobj 150 0 obj <>/Border[0 0 0]/H/N/Rect[385.422 285.333 476.117 276.037]/Subtype/Link/Type/Annot>> endobj 151 0 obj <>/Border[0 0 0]/H/N/Rect[359.566 235.333 487.801 225.877]/Subtype/Link/Type/Annot>> endobj 152 0 obj <>/Border[0 0 0]/H/N/Rect[289.739 195.333 416.546 186.037]/Subtype/Link/Type/Annot>> endobj 153 0 obj <>/Border[0 0 0]/H/N/Rect[378.356 165.333 476.867 156.037]/Subtype/Link/Type/Annot>> endobj 196 0 obj <> endobj 195 0 obj <> endobj 194 0 obj <> endobj 193 0 obj <> endobj 192 0 obj <> endobj 191 0 obj <> endobj 190 0 obj <> endobj 189 0 obj <> endobj 188 0 obj <> endobj 187 0 obj <> endobj 186 0 obj <> endobj 185 0 obj <> endobj 184 0 obj <> endobj 183 0 obj <> endobj 182 0 obj <> endobj 181 0 obj <> endobj 180 0 obj <> endobj 179 0 obj <> endobj 178 0 obj <> endobj 177 0 obj <> endobj 176 0 obj <> endobj 175 0 obj <> endobj 174 0 obj <> endobj 173 0 obj <> endobj 122 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 0 0 0 1 k /GS1 gs /T1_0 1 Tf -0.067 Tw 10 0 0 10 70.8661 724.8299 Tm (2,12% \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \f)Tj /Span<>> BDC ( )Tj EMC (\031\001\017\021\024\005 \030\026\027\024\005 \022\017\001\022\017 \023\030\ \024\021\017\r 6,99%)Tj /Span<>> BDC ( )Tj EMC (\227 )Tj 0.112 Tw 0 -1.218 TD (\r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \f)Tj /Span<>> BDC ( )Tj EMC (\024\021\022\030\t\021\024\005 \030\026\027\024\005 \(\210\234 0,26; 95%\ \212\222 0,10\226)Tj 0 Tw T* (0,68; )Tj /T1_1 1 Tf 2.273 0 Td (\032)Tj /T1_0 1 Tf 0.044 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,006\). \200)Tj /Span<>> BDC ( )Tj EMC (\f\017\f\021\036\n\026\021\017\004\036\f\022\024\n \024\002\024\030\036\ Menahem )Tj 0.15 Tw -2.273 -1.218 Td [(e)-12(t al. [12] \031\001\017\r\026\027\017\036 \030\026\027\t \027\036 \f\027\ \017\032\026\036\021 \004\026\f\021\024\021\031 \022\030\024)]TJ 0 Tw (-)Tj 0.188 Tw T* (\r\024\021\036\004\036\027\017\016)Tj /Span<>> BDC ( )Tj EMC (\227 5,6% \023\030\024\021\017\r 7,7% \(\210\234 0,83; 95% \212\222 )Tj 0 Tw T* (0,29\2261,77; )Tj /T1_1 1 Tf 4.575 0 Td (p)Tj /T1_0 1 Tf 0.105 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,63\). \200)Tj /Span<>> BDC ( )Tj EMC (\027\026\001\036\n \n\036\021\026\026\027\026\035\017\036 \021\026\022\032\ \036 \027\036 )Tj 0.312 Tw -4.575 -1.218 Td (\024\021\n\036\004\036\027\024 \007\024\f\021\024\r\036\030\027\t\b \030\ \026\035\017\004\017\005 \r)Tj /Span<>> BDC ( )Tj EMC (\004\026\f\021\024\021\036 \023\024\f\035\036)Tj 0 Tw (-)Tj 0.073 Tw T* [(\024\023\036\030\026\006\017\024\027\027\t\b )0.6(\022\030\024\r\024\021\036\004\036\027\017\005 )0.6(\r)]TJ /Span<>> BDC ( )Tj EMC [(\020\030\031\023\023\026\b )0.6(\f)]TJ /Span<>> BDC ( )Tj EMC 17.473 0 Td (\031\001\017\r\026\027\017\036\n )Tj 0.066 Tw -17.473 -1.218 Td (\030\026\027\t \017)Tj /Span<>> BDC ( )Tj EMC (\002\036 \027\036\020\024)Tj /Span<>> BDC ( )Tj EMC (\227 3,3% \023\030\024\021\017\r 6,0% \(\210\234 0,47; 95% )Tj 0.082 Tw T* (\212\222 0,18\2261,26; )Tj /T1_1 1 Tf 0 Tw (\032)Tj /T1_0 1 Tf 0.082 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,13\), \024\007\027\026\022\024, \027\031\032\027\024 \024\021\n\036\021\ \017\021\034, \004\021\024 )Tj 0.153 Tw T* (\004\026\f\021\024\021\026 \023\024\f\035\036\024\023\036\030\026\006\017\ \024\027\027\t\b \022\030\024\r\024\021\036\004\036\027\017\005 \r)Tj /Span<>> BDC ( )Tj EMC (\024\021\022\030\t)Tj 0 Tw (-)Tj T* (\021\024\005 \020\030\031\023\023\036 \r\f\036 \032\036 \023\024\004\021\ \017 \r)Tj /Span<>> BDC ( )Tj EMC (2 \030\026\026 \r\t\001\036.)Tj 0.209 Tw 0 -1.218 TD (\221 \007\030\031\020\024\005 \f\021\024\030\024\027\t, \031\001\017\r\026\ \027\017\036 \030\026\027\t \n\024\032\036\021 \023\030\017\r\036\f\021\017\ )Tj 0.2 Tw 0 -1.218 TD (\022)Tj /Span<>> BDC ( )Tj EMC (\n\036\027\034\001\036\005 \004\026\f\021\024\021\036 \r\024\027\017\022\ \027\024\r\036\027\017\016 \n\036\f\021\027\t\b \017\027\235\036\022)Tj 0 Tw (-)Tj 0.039 Tw 0 -1.218 TD (\006\017\024\027\027\t\b \024\f\035\024\032\027\036\027\017\005. \210\007\ \027\026\022\024, \023\024)Tj /Span<>> BDC ( )Tj EMC [(\007\026\027\027\t\n Khan e)-12(t al. )]TJ 0.087 Tw T* ([11], \004\026\f\021\024\021\026 \017\027\235\036\022\006\017\024\027\027\ \t\b \024\f\035\024\032\027\036\027\017\005 \f\024\f\021\026\r\035\016\036\ \021 )Tj -0.01 Tw T* (3,53% \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\031\001\017\r\026\027\017\017 \030\026\027\t \017)Tj /Span<>> BDC ( )Tj EMC (1,84%, \036\f\035\017 \030\026\027\031 \027\036 \031\001\017)Tj 0 Tw (-)Tj -0.018 Tw T* (\r\026\021\034 \(\210\234 1,81; 95% \212\222 0,63\2265,20; )Tj /T1_1 1 Tf 0 Tw (p)Tj /T1_0 1 Tf -0.018 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,27\). \203\026\023\030\024\021\017\r, )Tj 0.042 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC [(\n\036\021\026\026\027\026\035\017\036 Menahem e)-12(t al. [12] \004\026\f\021\024\021\026 \017\027\235\036\022\006\017)]TJ 0 Tw (-)Tj 0.186 Tw T* (\024\027\027\t\b \024\f\035\024\032\027\036\027\017\005 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\031\001\017\r\026\027\017\017 \030\026\027\t \002\t\035\026 3,1%, )Tj -0.003 Tw T* (\023\030\017)Tj /Span<>> BDC ( )Tj EMC [(\r\036\007\036\027\017\017 )0.5(\030\026\027\t )0.5(\023\030\016\n\024\005 \022\017\001\022\017 )0.5(\024\021\022\030\t\021\t\n \f\023\024\f\024\002\024\n )]TJ 0.118 Tw T* (\2574,9% \(\210\234 0,62; 95% \212\222 0,23\2261,62; )Tj /T1_1 1 Tf 0 Tw (p)Tj /T1_0 1 Tf 0.118 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,33\). \200)Tj /Span<>> BDC ( )Tj EMC (\027\026)Tj 0 Tw (-)Tj -0.046 Tw T* (\001\036\n \n\036\021\026\026\027\026\035\017\036 \004\026\f\021\024\021\ \026 \r\024\027\017\022\027\024\r\036\027\017\016 \017\027\235\036\022\006\ \017\024\027)Tj 0 Tw (-)Tj 0.071 Tw T* (\027\t\b \024\f\035\024\032\027\036\027\017\005 \f\024\f\021\026\r\017\035\ \026 3,29% \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \f)Tj /Span<>> BDC ( )Tj EMC (\031\001\017\021\024\005 )Tj 0.211 Tw T* [(\030\026\027\024\005 )0.5(\023\030\024\021\017\r )0.6(1,8% )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 9.561 0 Td [(\020\030\031\023\023\036 )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC 4.11 0 Td [(\024\021\022\030\t\021\t\n )0.5(\r\036\007\036\027\017\036\n )]TJ 0.129 Tw -13.671 -1.218 Td (\030\026\027\t \(\210\234 1,66; 95% \212\222 0,69\2264,00; )Tj /T1_1 1 Tf 0 Tw (\032)Tj /T1_0 1 Tf 0.129 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,26\). \230\026\022\017\n )Tj -0.019 Tw T* (\024\002\030\026\024\n, \031\001\017\r\026\027\017\036 \023\024\f\035\036\ \024\023\036\030\026\006\017\024\027\027\024\005 \030\026\027\t \027\036\ \023\030\017)Tj 0 Tw (-)Tj 0.022 Tw T* (\r\024\007\017\021 \022)Tj /Span<>> BDC ( )Tj EMC (\027\026\004\017\n\024\n\031 \031\n\036\027\034\001\036\027\017\033 \004\ \026\f\021\024\021\t \017\027\235\036\022\006\017\024\027)Tj 0 Tw (-)Tj 0.216 Tw T* (\027\t\b \024\f\035\024\032\027\036\027\017\005. \200)Tj /Span<>> BDC ( )Tj EMC (\030\016\007\036 \017\f\f\035\036\007\024\r\026\027\017\005 \024\021\n\036\ \004\026\036\021\f\016 )Tj 0.075 Tw T* [(\002\024\035\036\036 )0.5(\r\t\f\024\022\026\016 )0.6(\004\026\f\021\024\021\026 )0.5(\017\027\235\036\022\006\017\017 )0.6(\r)]TJ /Span<>> BDC ( )Tj EMC 15.109 0 Td [(\030\026\027\036 )0.5(\023\030\017)]TJ /Span<>> BDC ( )Tj EMC 4.079 0 Td (\031\001\017\r\026)Tj 0 Tw (-)Tj 0.089 Tw -19.188 -1.218 Td (\027\017\017. \212\026\027\027\t\005 \026\f\023\036\022\021 \n\024\032\036\ \021 \f\r\017\007\036\021\036\035\034\f\021\r\024\r\026\021\034 \024)Tj /Span<>> BDC ( )Tj EMC (\021\024\n, )Tj 0.042 Tw T* (\004\021\024 \235\024\030\n\017\030\024\r\026\027\017\036 \r\027\031\021\ \030\017\023\030\024\f\r\036\021\027\024\020\024 \001\r\026 \023\030\017\ \r\024\007\017\021 )Tj 0.122 Tw T* (\022)Tj /Span<>> BDC ( )Tj EMC (\023\035\024\b\024\n\031 \007\030\036\027\017\030\024\r\026\027\017\033 \ \023\024\f\035\036\024\023\036\030\026\006\017\024\027\027\024\005 \030\026\ \027\t, )Tj 0.472 Tw T* (\004\021\024 \f\023\024\f\024\002\f\021\r\031\036\021 \235\024\030\n\017\ \030\024\r\026\027\017\033 \035\024\022\026\035\034\027\024\020\024 \017\ \027)Tj 0 Tw (-)Tj 0.095 Tw T* (\235\036\022\006\017\024\027\027\024\020\024 \023\030\024\006\036\f\f\026\ . \230\026\022\032\036 \f\035\036\007\031\036\021 \024\021\n\036\021\017\ \021\034, \004\021\024 )Tj 0.231 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\023\030\017\r\036\007\036\027\027\t\b \017\f\f\035\036\007\024\r\026\027\ \017\016\b \027\036 \017\031\004\026\035\f\016 \r\024\023\030\024\f )Tj 0.163 Tw T* [(\f\024\f\021\024\016\021\036\035\034\027\024\f\021\017 )0.6(\r\027\031\021\030\017\023\030\024\f\r\036\021\027\024\020\024 )0.5(\001\r\026, )0.5(\r\024\n\024\032\027\024, )]TJ 0.322 Tw T* (\024\021\f\031\021\f\021\r\017\036 \030\026\035\017\004\017\005 \n\036\032\ \007\031 \020\030\031\023\023\026\n\017 \n\024\032\036\021 \002\t\021\034\ )Tj 0.238 Tw T* (\f\r\016\026\027\024 \f)Tj /Span<>> BDC ( )Tj EMC (\027\036\f\024\f\021\024\016\021\036\035\034\027\024\f\021\034\033 \001\r\ \026, \004\021\024 \023\030\017\r\024\007\017\035\024 )Tj 0.112 Tw T* (\022)Tj /Span<>> BDC ( )Tj EMC (\007\017\026\f\021\026\031 \022\030\026\036\r \030\026\027\t \017)Tj /Span<>> BDC ( )Tj EMC (\f\b\024\032\017\n \027\036\023\024\f\030\036\007\f\021\r\036\027\027\t\n\ )Tj 0 Tw T* (\030\036\031\035\034\021\026\021\026\n \035\036\004\036\027\017\016 \023\ \026\006\017\036\027\021\024\r.)Tj 0.094 Tw T* (\221\030\026\r\027\036\027\017\036 \f\030\036\007\027\036\020\024 \023\024\ \f\035\036\024\023\036\030\026\006\017\024\027\027\024\020\024 \022\024\005\ \022\024-\007\027\016 )Tj -0.052 Tw T* (\021\026\022\032\036 \027\036 \r\t\016\r\017\035\024 \030\026\035\017\004\ \017\005 \n\036\032\007\031 \020\030\031\023\023\026\n\017: \030\026\027\ \017\006\026 )Tj 0.044 Tw T* (\f\024\f\021\026\r\017\035\026 \r\f\036\020\024 \035\017\001\034 12 \004\ \026\f\024\r. \210\f\024\002\027\016\022\024\n \f\021\024\017\021 \017\f\ )Tj 0 Tw (-)Tj 0.057 Tw T* [(\f\035\036\007\024\r\026\027\017\036 )0.5(N)-14(our)-33(a )0.5([6], \r)]TJ /Span<>> BDC ( )Tj EMC [(\022\024\021\024\030\024\n )0.5(\023\026\006\017\036\027\021\t )0.5(\024\021\022\030\t\021\024\005 )]TJ 0.056 Tw T* [(\020\030\031\023\023\t )0.5(\027\026\b\024\007\017\035\017\f\034, )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC (\f\030\036\007\027\036\n, \r)Tj /Span<>> BDC ( )Tj EMC 13.947 0 Td [(\f\021\026\006\017\024\027\026\030\036 )0.5(\n\036\027\034\001\036 )]TJ 0.229 Tw -13.947 -1.218 Td (\027\026)Tj /Span<>> BDC ( )Tj EMC (2,5 \007\027\016, \024\007\027\026\022\024, \f\035\036\007\031\036\021 \024\ \021\n\036\021\017\021\034, \004\021\024 \007\035\017\021\036\035\034)Tj 0 Tw (-)Tj 0.029 Tw T* (\027\024\f\021\034 \020\024\f\023\017\021\026\035\017\026\006\017\017 \023\ \024\f\035\036 \n\017\027\017\017\027\r\026\017\r\027\024\005 \024\023\036\ \030\026)Tj 0 Tw (-)Tj -0.02 Tw T* (\006\017\017 \r)Tj /Span<>> BDC ( )Tj EMC (\007\026\027\027\024\n \017\f\f\035\036\007\024\r\026\027\017\017 \f\024\ \f\021\026\r\017\035\026 \002\024\035\036\036 10)Tj /Span<>> BDC ( )Tj EMC (\007\027\036\005, )Tj 0.016 Tw T* [(\004\021\024, )0.5(\r\017\007\017\n\024, \024\002\031\f\035\024\r\035\036\027\024 )0.5(\023\024\035\017\021\017\022\024\005 )0.5(\022\035\017\027\017\022\017. \200)]TJ /Span<>> BDC ( )Tj EMC 20.252 0 Td (\007\r\031\b )Tj 0.297 Tw -20.252 -1.218 Td (\007\030\031\020\017\b \017\f\f\035\036\007\024\r\026\027\017\016\b \f\030\ \036\007\027\016\016 \023\030\024\007\024\035\032\017\021\036\035\034\027\ \024\f\021\034 )Tj 0.167 Tw T* (\027\026\b\024\032\007\036\027\017\016 \r)Tj /Span<>> BDC ( )Tj EMC (\f\021\026\006\017\024\027\026\030\036 \f\024\f\021\026\r\017\035\026 2\226\ 3)Tj /Span<>> BDC ( )Tj EMC (\007\027\016 \017)Tj /Span<>> BDC ( )Tj EMC (\007\024)Tj 0 Tw (-)Tj 0.031 Tw T* (\f\021\024\r\036\030\027\t\036 \030\026\035\017\004\017\016 \n\036\032\007\ \031 \020\030\031\023\023\026\n\017 \024\021\n\036\004\036\027\t \035\017\ \001\034 )Tj 0.037 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC [(\017\f\f\035\036\007\024\r\026\027\017\017 L)35(ee [16], \020\007\036 \023\026\006\017\036\027\021\t \023\030\017)]TJ /Span<>> BDC ( )Tj EMC (\024\021\022\026\036 \024\021 )Tj 0.1 Tw 23.244 64.543 Td [(\031\001\017\r\026\027\017\016 )0.5(\030\026\027\t \027\026\b\024\007\017\035\017\f\034 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC [(\f\021\026\006\017\024\027\026\030\036 )0.5(\027\026)]TJ /Span<>> BDC ( )Tj EMC 19.156 0 Td (\023\024\035\007\027\016 )Tj 0 Tw -19.156 -1.218 Td (\n\036\027\034\001\036.)Tj 0.436 Tw T* (\221\017\f\021\036\n\026\021\017\004\036\f\022\017\005 \024\002\024\030\ \r)Tj /Span<>> BDC ( )Tj EMC (\030\031\f\f\022\024\016\t\004\027\024\005 \035\017\021\036\030\026)Tj 0 Tw (-)Tj 0.318 Tw T* (\021\031\030\036)Tj /Span<>> BDC ( )Tj EMC (\227 \f\030\026\r\027\036\027\017\036 \030\036\031\035\034\021\026\021\024\ \r \r\036\007\036\027\017\016 \030\026\027 \023\030\016)Tj 0 Tw (-)Tj 0.098 Tw T* (\n\024\005 \022\017\001\022\017 \024\021\022\030\t\021\t\n \017\035\017 \ \026\022\030\t\021\t\n \f\023\024\f\024\002\024\n \023\024\f\035\036 )Tj 0.028 Tw T* [(\021\030\026\027\f\026\027\026\035\034\027\024\005 )0.6(\220\027\007\024\n\017\022\030\024\b\017\030\031\030\020\017\017)]TJ /Span<>> BDC ( )Tj EMC 15.014 0 Td [(\227 )0.5(\023\036\030\r\t\005 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 5.333 0 Td (\f\r\024)Tj 0 Tw (-)Tj 0.072 Tw -20.347 -1.218 Td (\036\n \030\024\007\036. \212\024\f\021\024\017\027\f\021\r\024\n \220\021\ \024\005 \030\026\002\024\021\t \016\r\035\016\036\021\f\016 \021\024, \004\ \021\024 )Tj 0.134 Tw T* (\024\027\026 \016\r\035\016\036\021\f\016 \021\030\036\021\034\017\n \n\036\ \021\026\026\027\026\035\017\024\n \r)Tj /Span<>> BDC ( )Tj EMC (\n\017\030\036 \023\024)Tj /Span<>> BDC ( )Tj EMC (\007\026\027)Tj 0 Tw (-)Tj 0.313 Tw T* (\027\024\005 \021\036\n\036 \f)Tj /Span<>> BDC ( )Tj EMC (\027\026\017\002\024\035\034\001\017\n \022\024\035\017\004\036\f\021\r\024\ \n \r\022\035\033\004\036\027\027\t\b )Tj 0 Tw T* (\023\026\006\017\036\027\021\024\r.)Tj 0.412 Tw T* (\025 \024\020\030\026\027\017\004\036\027\017\016\n \n\036\021\026\026\027\ \026\035\017\026 \n\024\032\027\024 \024\021\027\036\f\021\017 \030\036\ )Tj 0 Tw (-)Tj 0.329 Tw T* (\021\030\024\f\023\036\022\021\017\r\027\t\005 \b\026\030\026\022\021\036\ \030 \002\024\035\034\001\017\027\f\021\r\026 \r\022\035\033\004\036\027\ \027\t\b )Tj 0.184 Tw 0 -1.218 TD [(\017\f\f\035\036\007\024\r\026\027\017\005, )0.5(\020\036\021\036\030\024\020\036\027\027\024\f\021\034 \017\f\f\035\036\007\ \024\r\026\027\017\005 )0.5(\023\024)]TJ /Span<>> BDC ( )Tj EMC (\027\036)Tj 0 Tw (-)Tj 0.36 Tw 0 -1.218 TD (\022\024\021\024\030\t\n \023\026\030\026\n\036\021\030\026\n. \230\026\022\ \017\n \024\002\030\026\024\n, \023\030\024\r\036\007\036\027\017\036 )Tj 0.053 Tw 0 -1.218 TD [(\027\024\r\t\b )0.5(\030\026\027\007\024\n\017\017\030\024\r\026\027\027\t\b )0.5(\017\f\f\035\036\007\024\r\026\027\017\005 )0.6(\023\024\r\024\035\017\035\024 )]TJ 0.059 Tw T* (\002\t \024\006\036\027\017\021\034 \023\030\036\017\n\031\013\036\f\021\ \r\026 \017)Tj /Span<>> BDC ( )Tj EMC (\027\036\007\024\f\021\026\021\022\017 \r\036\007\036\027\017\016 \030\026\ \027 )Tj 0.024 Tw T* (\023\030\016\n\024\005 \022\017\001\022\017 \024\021\022\030\t\021\t\n \017\ \035\017 \026\022\030\t\021\t\n \f\023\024\f\024\002\024\n \023\024)Tj 0 Tw (-)Tj T* (\f\035\036 \021\030\026\027\f\026\027\026\035\034\027\024\005 \b\017\030\ \031\030\020\017\017.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 303.3769 481.2698 Tm [(\020)21(\026\027\r\242\224\034\022\031\034)]TJ 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0 Tc 0.454 Tw 10 0 0 10 303.3071 456.9138 Tm (\211\001\017\r\026\027\017\036 \030\026\027\t \023\024\f\035\036 \230\213\ \204 \031\r\036\035\017\004\017\r\026\036\021 \023\030\024\007\024\035)Tj 0 Tw (-)Tj 0.303 Tw T* (\032\017\021\036\035\034\027\024\f\021\034 \024\023\036\030\026\006\017\017\ \017)Tj /Span<>> BDC ( )Tj EMC (\027\036 \023\030\017\r\024\007\017\021 \022)Tj /Span<>> BDC ( )Tj EMC (\f\021\026\021\017\f\021\017)Tj 0 Tw (-)Tj 0.231 Tw T* [(\004\036\f\022\017 )0.5(\007\024\f\021\024\r\036\030\027\024\n\031 )0.6(\f\027\017\032\036\027\017\033 )0.6(\022\026\022 )0.5(\004\026\f\021\024\021\t )0.5(\023\024\f\035\036)]TJ 0 Tw (-)Tj 0.283 Tw T* (\024\023\036\030\026\006\017\024\027\027\t\b \022\030\024\r\024\021\036\004\ \036\027\017\005, \021\026\022 \017)Tj /Span<>> BDC ( )Tj EMC (\017\027\235\036\022\006\017\024\027\027\t\b )Tj 0 Tw T* (\024\f\035\024\032\027\036\027\017\005.)Tj /T1_3 1 Tf 0.023 Tw 0 -2.436 TD (\223\030\032\255\020\034\036 \032\026\020\017\022\017\026)Tj /T1_0 1 Tf 0.006 Tc 0.296 Tw 0 -1.218 TD [(\025)1.9(\024)1.7(\027)7.7(\006\036)-0.8(\023)8.2(\006\017)0.5(\016)6( \017)]TJ /Span<>> BDC 5.626 0 Td ( )Tj EMC [(\007\017)8.7()-3.9(\026)5.7(\005)7.8(\027)19.1(:)]TJ /T1_1 1 Tf 0 Tc 0.302 Tw 3.762 0 Td [( \201)-17.3(\023)3.3(\031)2.9(\013)9.2(\t)9.9(\031)-0.9(\031)6.6(\027)]TJ /Span<>> BDC ( )Tj EMC [(\240)19.4(.)28.5(\216)24.3(.)7.8(, \212)23.8(\020)1.7(\005)4.7(\026)4.8(\013)9.8(\n)9.6(\027)]TJ /Span<>> BDC ( )Tj EMC [(\036)22.8(.)29.3(\210)122(.)7.8(, )]TJ -0.01 Tc 0.01 Tw -9.388 -1.218 Td [(\224)2.2(\031)-10.9(\032)-4.6(\021)-2.3(\020\001)-6.7(\n\027)]TJ /Span<>> BDC 4.233 0 Td ( )Tj EMC [(\207)-12.1(.)18.5(\216)14.4(.)]TJ /T1_0 1 Tf 0 Tc 0 Tw -4.233 -1.218 Td [(\221)-4.6(\002)-9.9(\024)0.7(\030 \017)]TJ /Span<>> BDC ( )Tj EMC [(\024)-11.8(\002)3(\030)-11.3(\026)-6.4(\002)-9.9(\024)-10.8(\021)-17.7(\022)-19.1(\026 \n)1.3(\026)-11.8(\021)-9.9(\036)-1.7(\030)-7.6(\017)-0.6(\026)-33.1(\035\026)3.7(:)]TJ /T1_1 1 Tf -0.01 Tc 0.01 Tw [( \207)-1.1(\025)-2.8(\021\025\203)-10.9(\020\021)]TJ /Span<>> BDC 15.997 0 Td ( )Tj EMC [(\212)83.9(.)17.5(\222)-1.4(.)]TJ /T1_0 1 Tf 0.002 Tc 0.529 Tw -15.997 -1.218 Td [(\203)7.2(\026\023)4.2(\017\f)-10.8(\026)1.7(\027)3.7(\017)-6.7(\036)2.1( \021)-7.9(\036)-3.4(\022\f)-33.9(\021)-19.5(\026)5.7(:)]TJ /T1_1 1 Tf -0.01 Tc 0.541 Tw 8.225 0 Td [( \201)-27.3(\023)-6.7(\031)-7.2(\013)-0.7(\t\031)-10.8(\031)-3.4(\027)]TJ /Span<>> BDC 4.419 0 Td ( )Tj EMC [(\240)9.4(.)18.5(\216)14.3(.)-2.2(,)-10( \207)-1.2(\025)-2.7(\021\025\203)-10.9(\020\021)]TJ /Span<>> BDC 6.967 0 Td ( )Tj EMC [(\212)83.9(.)17.5(\222)-1.4(.)-2.2(,)-10( )]TJ 0.01 Tw -19.611 -1.218 Td [(\212)13.8(\020)-8.3(\005)-5.2(\026)-5.2(\013\n\027)]TJ /Span<>> BDC 3.475 0 Td ( )Tj EMC [(\036)12.8(.)19.3(\210)112(.)]TJ /T1_0 1 Tf 0 Tc 0 Tw -3.475 -1.218 Td [(\217)5.5(\036)-19(\007)-20.1(\026\022)-32.6(\021)-17.7(\017)1.5(\030)-11.8(\024)-4.4(\r)-8.8(\026\027)1.8(\017)-8.7(\036)6.5(:)]TJ /T1_1 1 Tf -0.01 Tc 0.01 Tw [( \212)13.8(\020)-8.3(\005)-5.3(\026)-5.1(\013\n\027)]TJ /Span<>> BDC 10.842 0 Td ( )Tj EMC [(\036)12.8(.)19.3(\210)112.1(.)]TJ /T1_3 1 Tf 0 Tc 0.023 Tw -10.842 -2.436 Td (AUTHORS CONTRIBUTION)Tj /T1_0 1 Tf 0.106 Tw T* [(C)-6.5(o)0.8(nce)-0.7(p)-12.3(t a)2.4(n)-4.6(d d)-5.5(e)-13.3(s)-16.6(i)3.2(g)1.2(n o)-2.2(f t)-16.7(h)-5.3(e s)-20(t)-12.8(ud)-10.8(y)-11.8(:)]TJ /T1_1 1 Tf [( M)10.5(i)2.6(c)1.8(h)4.8(a)-4.5(e)-1.9(l)]TJ /Span<>> BDC ( )Tj EMC [(V)53.1(.)]TJ /Span<>> BDC ( )Tj EMC [(A)3.6(l)4.8(ek)-17.5(s)5(e)-6.2(e)-4(v)33.6(, )]TJ 0.001 Tc -0.001 Tw T* [(E)26.4(u)3.1(g)-1.5(e)-1.5(n)7.2(y)]TJ /Span<>> BDC 2.797 0 Td ( )Tj EMC (G.)Tj /Span<>> BDC 1.041 0 Td ( )Tj EMC [(R)-8(y)7.9(b)0.6(a)2.7(k)13.9(ov)34.6(,)1( S)17.3(t)3.3(an)7.2(i)12(s)10.3(l)4.4(a)-3.4(v)]TJ /Span<>> BDC 7.378 0 Td ( )Tj EMC [(V)54.1(.)]TJ /Span<>> BDC 0.955 0 Td ( )Tj EMC [(C)4.2(h)2.9(e)-0.7(r)-13.5(n)7.2(ys)10.6(h)2.9(ov)]TJ /T1_0 1 Tf 0 Tc 1.014 Tw -12.171 -1.218 Td [(C)-6.5(o)-5.8(l)-19(l)-14.3(e)-9.4(c)-32.5(t)-37.3(i)3.2(o)0.8(n )0.5(a)2.4(n)-4.6(d )0.6(p)-3.8(r)-6(o)-7(ce)-13.3(s)-12.8(s)-16.6(i)7.1(n)-1.9(g )0.6(o)-2.2(f )0.6(t)-16.7(h)-5.3(e )0.5(m)1.8(a)-8.4(t)-15.1(e)-2.1(r)-48(i)5.1(a)-1.5(l)-22.5(:)]TJ /T1_1 1 Tf 0 Tw ( )Tj T* [(R)7.2(om)4.3(a)-0.8(n)]TJ /Span<>> BDC ( )Tj EMC [(K)-13.5(.)]TJ /Span<>> BDC ( )Tj EMC [(S)21.5(i)8.4(n)6.2(i)0.9(t)-29.1(s)-10.7(yn)]TJ /T1_0 1 Tf 1.044 Tw T* [(W)3.1(r)-48(i)-6(t)-37.4(i)7.1(n)-1.9(g o)-2.2(f t)-16.7(h)-5.3(e t)-15.2(e)-23.9(x)-36(t)-20.1(:)]TJ /T1_1 1 Tf [( M)10.5(i)2.6(c)1.8(h)4.8(a)-4.5(e)-1.9(l)]TJ /Span<>> BDC ( )Tj EMC [(V)53.1(.)]TJ /Span<>> BDC ( )Tj EMC [(A)3.6(l)4.8(ek)-17.5(s)4.9(e)-6.2(e)-4(v)33.6(, )]TJ 0 Tw T* [(R)7.2(om)4.3(a)-0.8(n)]TJ /Span<>> BDC ( )Tj EMC [(K)-13.5(.)]TJ /Span<>> BDC ( )Tj EMC [(S)21.5(i)8.4(n)6.2(i)0.9(t)-29.1(s)-10.7(yn)-6(, E)25.5(u)2.1(g)-2.5(e)-2.6(n)6.2(y)]TJ /Span<>> BDC ( )Tj EMC [(G)-1.4(.)]TJ /Span<>> BDC ( )Tj EMC [(R)-9(y)6.9(ba)1.7(k)12.9(o)-0.6(v)]TJ /T1_0 1 Tf 0.006 Tc -0.006 Tw T* [(E)11.6(dit)-31.4(i)13.1(n)4.1(g)15(:)]TJ /T1_1 1 Tf 0.001 Tc -0.001 Tw 3.238 0 Td [( E)26.4(u)3.1(g)-1.4(e)-1.6(n)7.2(y)]TJ /Span<>> BDC 3.03 0 Td ( )Tj EMC (G.)Tj /Span<>> BDC 1.041 0 Td ( )Tj EMC [(R)-8(y)7.9(b)0.6(a)2.7(k)13.9(ov)]TJ /T1_3 1 Tf 0 Tc 0.023 Tw -7.309 -2.436 Td (\255\026\036\031\036\025\034\224 \017\225 \032\026\020\017\022\032\221 \(\ ORCID\))Tj /T1_0 1 Tf 0.334 Tw T* (\217\t\002\026\022\024\r \213\r\020\036\027\017\005 \206\036\027\027\026\ \007\017\036\r\017\004)Tj /Span<>> BDC ( )Tj EMC (\227 \007.\n.\027., \023\030\024\235\036\f)Tj 0 Tw (-)Tj 0.561 Tw T* (\f\024\030 \217\202\203, \030\031\022\024\r\024\007\017\021\036\035\034 \ \024\021\007\036\035\026 \024\027\022\024\023\030\024\022\021\024\035\024\ \020\017\017 )Tj 0.221 Tw T* (\205\206\207\211 \253\203\204\222\037 \022\024\035\024\023\030\024\022\021\ \024\035\024\020\017\017 \017\n\036\027\017 \202.\203. \217\t\032\017\b\273\ )Tj 0 Tw T* (\204\017\027\007\030\026\r\026 \217\024\f\f\017\017; ORCID 0000-0002-39\ 19-9067)Tj 0.16 Tw T* (\223\036\030\027\t\001\024\r \221\021\026\027\017\f\035\026\r \200\017\022\ \021\024\030\024\r\017\004)Tj /Span<>> BDC ( )Tj EMC (\227 \007.\n.\027., \026\r\036\007\031)Tj 0 Tw (-)Tj 0.206 Tw T* (\033\013\017\005 \024\021\007\036\035\036\027\017\016 \n\026\035\024\017\ \027\r\026\017\r\027\024\005 \024\027\022\024\023\030\024\022\021\024\035\ \024\020\017\017 )Tj 0.221 Tw T* (\205\206\207\211 \253\203\204\222\037 \022\024\035\024\023\030\024\022\021\ \024\035\024\020\017\017 \017\n\036\027\017 \202.\203. \217\t\032\017\b\273\ )Tj 0 Tw T* (\204\017\027\007\030\026\r\026 \217\024\f\f\017\017; ORCID 0000-0002-62\ 12-9454)Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\214)10(\211\036\033 \035\030\032\t\033)30(\b)42(\032)-21(\240\033\233)]TJ 57.136 0 Td (REVIEW)Tj -57.136 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 23, \023\0221)69(, 202)69(4)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 23, \023\0221)69(, 202)69(4)]TJ /T1_5 1 Tf 25 0 0 25 20.8026 56.0378 Tm (186)Tj ET endstream endobj 105 0 obj <>>>/Subtype/Form>>stream 1 0.68 0 0.12 k /GS0 gs 70.866 54.638 453.543 1.375 re f 70.866 52.257 453.543 1.375 re f 70.866 755.476 453.543 1.375 re f endstream endobj 119 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\214\016\222\025\221\013\006\001\025 \007\220 \025\006)-10(\026)11(\013\r\007\205\026\216 \002\013\001\215 \221\002\205\024\025\203 \n\220\ \n\220 \221\025\006)-9.9(\007\016 \026\002\013\001\006\013\001\013\007\216\001\025\203 )]TJ 0 -1 TD [(\232\001\201\025\024\220\n\002\025\207\220\002\215\002\202\220\220 \025\026\ \n\002\020\026)11.1(\025\203? \(\006\220\006)-10(\026)11(\016\024\013\026\220\017\016\006\n\220\203 \025\f\222\025\002 \220\022\024\ \016\026)11(\013\013\001\013\007\220\222\))]TJ 39.202 1 Td [(Is it safe to leav)12.1(e r)31(ectal w)11(ound opened af)-31(ter tr)21(ansanal )]TJ -0.067 -1 Td [(micr)20(osur)31.1(ger)-31(y? A s)10.1(y)9.9(stematic r)31(e)11(vie)11(w and meta-analy)10.1(sis.)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0.351 Tw 10 0 0 10 42.5197 724.8299 Tm (\203\026 \023\036\030\r\024\n \220\021\026\023\036 \002\t\035 \023\030\024\ \r\036\007\036\027 \026\027\026\035\017 \030\026\035\017\004\017\005 )Tj 0.038 Tw 0 -1.218 TD (\f\030\036\007\027\036\020\024 \030\026\n\036\030\026 \007\036\235\036\022\ \021\026 \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\026\b \024\021\022\030\t\021\024\020\024 \017)Tj /Span<>> BDC ( )Tj EMC (\026)Tj 0 Tw (-)Tj 0.15 Tw T* (\022\030\t\021\024\020\024 \r\036\007\036\027\017\016 \030\026\027\t \023\ \030\016\n\024\005 \022\017\001\022\017. \203\036 \002\t\035\024 \r\t)Tj 0 Tw (-)Tj 0.273 Tw T* (\016\r\035\036\027\024 \f\021\026\021\017\f\021\017\004\036\f\022\017 \027\ \026\004\017\n\024\005 \030\026\027\017\006\t; 95% \212\222 )Tj 0 Tw T* (\2570,60\2260,22; \()Tj /T1_2 1 Tf (\032)Tj /T1_1 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,36\) \023\030\017)Tj /Span<>> BDC ( )Tj EMC (I)Tj 5.83 0 0 5.83 154.5184 679.4479 Tm (2)Tj /Span<>> BDC 10 0 0 10 157.4334 676.1179 Tm ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (73% \(\217\017\f.)Tj /Span<>> BDC ( )Tj EMC (2\).)Tj 0.287 Tw -11.491 -1.218 Td (\223\026\f\021\024\021\026 \023\024\f\035\036\024\023\036\030\026\006\017\ \024\027\027\t\b \022\030\024\r\024\021\036\004\036\027\017\005 \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023)Tj 0 Tw (-)Tj 0.204 Tw T* (\023\036, \020\007\036 \030\026\027\026 \r\036\035\026\f\034 \024\021\022\ \030\t\021\t\n \f\023\024\f\024\002\024\n, \f\024\f\021\026\r\017\035\026\ )Tj 0.14 Tw 0 -1.218 TD (6% \(23/383\) \023\030\024\021\017\r 3,3% \(14/425\) \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \f)Tj /Span<>> BDC ( )Tj EMC (\031\001\017)Tj 0 Tw (-)Tj 0.105 Tw 0 -1.218 TD (\r\026\027\017\036\n \030\026\027\t \(\210\234 0,47; 95% \212\222 0,18\226\ 1,26\) \(\217\017\f.)Tj /Span<>> BDC ( )Tj EMC (3\). )Tj 0.153 Tw 0 -1.218 TD (\215\030\017)Tj /Span<>> BDC ( )Tj EMC 2.006 0 Td [(\220\021\024\n )0.5(\023\024\035\031\004\036\027\026 )0.5(\027\017\022\026\016 )0.5(\020\036\021\036\030\024\020\036\027\027\024\f\021\034 )0.5(\017\f\f\035\036\007\024)]TJ 0 Tw (-)Tj 0.046 Tw -2.006 -1.218 Td [(\r\026\027\017\005 )0.6(\(I)]TJ 0 Tw 5.83 0 0 5.83 77.5842 606.3798 Tm (2)Tj 0.046 Tw /Span<>> BDC 10 0 0 10 80.4992 603.0498 Tm ( )Tj EMC 0.279 0 Td (=)Tj /Span<>> BDC ( )Tj EMC 0.778 0 Td [(31%\), )0.5(\004\021\024 )0.6(\031\022\026\t\r\026\036\021 )0.5(\027\026)]TJ /Span<>> BDC ( )Tj EMC 9.948 0 Td [(\017\b )0.5(\024\007\027\024\030\024\007\027\024\f\021\034. )]TJ -0.001 Tw -14.803 -1.218 Td (\230\026\022\017\n \024\002\030\026\024\n, \n\036\021\026\026\027\026\035\ \017 \007\026\027\027\t\b \023\024\022\026\026\035, \004\021\024 \031\001\ \017)Tj 0 Tw (-)Tj 0.012 Tw 0 -1.218 TD (\r\026\027\017\036 \030\026\027\t \023\024\f\035\036 \230\224\204 \023\030\ \017\r\024\007\017\021 \022)Tj /Span<>> BDC ( )Tj EMC (\f\027\017\032\036\027\017\033 \004\026\f\021\024\021\t )Tj 0.098 Tw T* (\023\024\f\035\036\024\023\036\030\026\006\017\024\027\027\t\b \022\030\024\ \r\024\021\036\004\036\027\017\005 \r)Tj /Span<>> BDC ( )Tj EMC (\007\r\026 \030\026\026, \024\007\027\026)Tj 0 Tw (-)Tj 0.233 Tw T* (\022\024, \007\026\027\027\t\036 \030\026\035\017\004\017\016 \f\021\026\ \021\017\f\021\017\004\036\f\022\017 \027\036 \007\024\f\021\024\r\036\030\ \027\t )Tj 0 Tw T* (\()Tj /T1_2 1 Tf (\032)Tj /T1_1 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,13\).)Tj 0.683 Tw T* (\210\002\013\026\016 \004\026\f\021\024\021\026 \017\027\235\036\022\006\ \017\024\027\027\t\b \024\f\035\024\032\027\036\027\017\005 \023\024)Tj 0 Tw (-)Tj 0.464 Tw T* (\f\035\036 \021\030\026\027\f\026\027\026\035\034\027\024\005 \220\027\007\ \024\n\017\022\030\024\b\017\030\031\030\020\017\017 \f\024\f\021\026\r\017\ \035\026 )Tj 0.072 Tw T* (3,3% \(14/425\) \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \f)Tj /Span<>> BDC ( )Tj EMC (\031\001\017\021\024\005 \030\026\027\024\005 \023\030\024\021\017\r 1,8\ % )Tj -0.023 Tw T* (\(7/383\) \f)Tj /Span<>> BDC ( )Tj EMC (\024\021\022\030\t\021\t\n \r\036\007\036\027\017\036\n \030\026\027\t \(\ \210\234 1,66; 95% \212\222 )Tj 0.151 Tw T* (0,69\2264,00 \(\217\017\f.)Tj /Span<>> BDC ( )Tj EMC (4\). \221\024\002\030\026\027\027\t\036 \007\026\027\027\t\036 \021\026\022\ \032\036 \017\n\036\035\017 )Tj 0.06 Tw T* [(\027\017\022\031\033 )0.6(\020\036\021\036\030\024\020\036\027\027\024\f\021\034 )0.5(\(I)]TJ 0 Tw 5.83 0 0 5.83 149.1982 472.4218 Tm (2)Tj 0.06 Tw /Span<>> BDC 10 0 0 10 152.1131 469.0918 Tm ( )Tj EMC 0.292 0 Td (=)Tj /Span<>> BDC ( )Tj EMC 0.793 0 Td [(0\). )0.5(\211\001\017\r\026\027\017\036 )0.6(\023\024\f\035\036\024\023\036)]TJ 0 Tw (-)Tj 0.114 Tw -12.044 -1.218 Td (\030\026\006\017\024\027\027\024\005 \030\026\027\t \027\036 \023\030\017\ \r\036\035\024 \022)Tj /Span<>> BDC ( )Tj EMC (\f\021\026\021\017\f\021\017\004\036\f\022\017 \007\024\f\021\024)Tj 0 Tw (-)Tj 0.009 Tw T* (\r\036\030\027\024\n\031 \f\027\017\032\036\027\017\033 \004\026\f\021\024\ \021\t \017\027\235\036\022\006\017\024\027\027\t\b \024\f\035\024\032\027\ \036)Tj 0 Tw (-)Tj T* (\027\017\005 \()Tj /T1_2 1 Tf (\032)Tj /T1_1 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,26\).)Tj 0.944 Tw T* (\202\027\026\035\017 \f\030\036\007\027\036\005 \023\030\024\007\024\035\ \032\017\021\036\035\034\027\024\f\021\017 \024\023\036\030\026\006\017\017\ )Tj -0.053 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC 0.653 0 Td (2)Tj /Span<>> BDC ( )Tj EMC 0.679 0 Td [(\020\030\031\023\023\026\b )0.6(\023\024\022\026\026\035, )0.5(\004\021\024 )0.5(\023\030\017)]TJ /Span<>> BDC ( )Tj EMC 10.29 0 Td [(\031\001\017\r\026\027\017\017 )0.6(\023\024\f\035\036\024\023\036\030\026\006\017)]TJ 0 Tw (-)Tj 0.108 Tw -11.623 -1.218 Td [(\024\027\027\024\005 )0.5(\030\026\027\t \r\030\036\n\016 )0.5(\024\023\036\030\026\006\017\017 \031\r\036\035\017\004\017\r\026\036\021\ \f\016, )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 19.857 0 Td (\f\030\036\007)Tj 0 Tw (-)Tj 0.21 Tw -19.857 -1.218 Td (\027\036\n, \027\026)Tj /Span<>> BDC ( )Tj EMC (7\2268)Tj /Span<>> BDC ( )Tj EMC (\n\017\027\031\021; 95% \212\222 \2572,21\22617,6; \()Tj /T1_2 1 Tf 0 Tw (\032)Tj /T1_1 1 Tf 0.21 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,13\) )Tj 0 Tw T* (\023\030\017)Tj /Span<>> BDC ( )Tj EMC (I)Tj 5.83 0 0 5.83 63.7993 374.9978 Tm (2)Tj /Span<>> BDC 10 0 0 10 66.7143 371.6678 Tm ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (63% \(\217\017\f.)Tj /Span<>> BDC ( )Tj EMC (5\).)Tj -0.044 Tw -2.419 -1.218 Td (\215\030\017 \024\006\036\027\022\036 \f\030\036\007\027\036\005 \023\030\ \024\007\024\035\032\017\021\036\035\034\027\024\f\021\017 \023\024\f\035\ \036\024\023\036\030\026)Tj 0 Tw (-)Tj -0.011 Tw T* (\006\017\024\027\027\024\020\024 \023\030\036\002\t\r\026\027\017\016 \r\ )Tj /Span<>> BDC ( )Tj EMC (\f\021\026\006\017\024\027\026\030\036 \023\026\006\017\036\027\021\t \r\ )Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023)Tj 0 Tw (-)Tj 0.24 Tw T* (\023\036 \031\001\017\r\026\027\017\016 \030\026\027\t, \r)Tj /Span<>> BDC ( )Tj EMC (\f\030\036\007\027\036\n, \027\026\b\024\007\017\035\017\f\034 \007\024\035\ \034\001\036 )Tj 0.251 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC (12 \004\026\f\024\r, \024\007\027\026\022\024 \023\024\035\031\004\036\027\ \027\t\036 \030\026\035\017\004\017\016 \f\021\026\021\017\f)Tj 0 Tw (-)Tj 0.17 Tw T* [(\021\017\004\036\f\022\017 )0.5(\027\036 \007\024\f\021\024\r\036\030\027\t )0.5(\(\2570,47; )0.5(95% \212\222 \2571,01\2260,06; )]TJ /T1_2 1 Tf 0 Tw T* (\032)Tj /T1_1 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,08\) \023\030\017)Tj /Span<>> BDC ( )Tj EMC (I)Tj 5.83 0 0 5.83 101.1188 301.9298 Tm (2)Tj /Span<>> BDC 10 0 0 10 104.0338 298.5998 Tm ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (5% \(\217\017\f.)Tj /Span<>> BDC ( )Tj EMC (6\).)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 275.0305 724.8299 Tm [(\037\036)10(\032\223\212\226\034\022\031\034)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0 Tc 0.283 Tw 10 0 0 10 274.9606 700.4739 Tm [(\230\030\026\027\f\026\027\026\035\034\027\026\016 )0.6(\220\027\007\024\n\017\022\030\024\b\017\030\031\030\020\017\016 )0.6(\016\r\035\016\036\021\f\016 )0.5(\n\017\027\017)]TJ 0 Tw (-)Tj 0.104 Tw T* (\n\026\035\034\027\024 \017\027\r\026\017\r\027\t\n \017)Tj /Span<>> BDC ( )Tj EMC (\002\036\024\023\026\f\027\t\n \n\036\021\024\007\024\n \035\036\004\036\ \027\017\016 )Tj 0.246 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\035\036\021\026\035\034\027\024\f\021\034\033, \f\021\030\036\n\016\013\ \036\005\f\016 \022)Tj /Span<>> BDC ( )Tj EMC (0 [13]. \203\026\f\021\024\016\013\017\005 )Tj 0.347 Tw T* (\n\036\021\026\026\027\026\035\017 \024\002\255\036\007\017\027\016\036\ \021 \030\036\031\035\034\021\026\021\t \f\030\026\r\027\017\021\036\035\ \034\027\t\b )Tj 0.116 Tw T* (\017\f\f\035\036\007\024\r\026\027\017\005 \023\026\006\017\036\027\021\024\ \r, \023\036\030\036\027\036\f\001\017\b \023\024\035\027\024\f\021\036\027\ \027\024\036 )Tj 0.234 Tw 0 -1.218 TD (\031\007\026\035\036\027\017\036 \027\024\r\024\024\002\030\026\024\r\026\ \027\017\005 \023\030\016\n\024\005 \022\017\001\022\017 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\023\024)Tj 0 Tw (-)Tj 0.002 Tw 0 -1.218 TD [(\n\024\013\017 \021\030\026\027\f\026\027\026\035\034\027\024\005 )0.5(\220\027\007\024\n\017\022\030\024\b\017\030\031\030\020\017\017, )0.5(\022\024\020\007\026 \030\026\027\026 )]TJ 0.095 Tw T* (\023\030\016\n\024\005 \022\017\001\022\017 \002\t\035\026 \035\017\002\024\ \031\001\017\021\026, \035\017\002\024 \024\f\021\026\r\035\036\027\026\ \024\021)Tj 0 Tw (-)Tj 0.207 Tw T* (\022\030\t\021\024\005. \200\024\023\030\024\f \024)Tj /Span<>> BDC ( )Tj EMC (\027\036\024\002\b\024\007\017\n\024\f\021\017 \031\001\017\r\026\027\017\ \016 \023\024\f\035\036)Tj 0 Tw (-)Tj -0.067 Tw T* [(\024\023\036\030\026\006\017\024\027\027\024\005 )0.5(\030\026\027\t \023\030\016\n\024\005 )0.5(\022\017\001\022\017 \r)]TJ /Span<>> BDC ( )Tj EMC [(\027\026\f\021\024\016\013\036\036 )0.5(\r\030\036\n\016 )]TJ 0.103 Tw 0 -1.218 TD (\024\f\021\026\036\021\f\016 \024\021\022\030\t\021\t\n \017, \026\004\026\ \f\021\031\033, \026\r\017\f\017\021 \024\021 \023\030\036\007\023\024\004\ )Tj 0 Tw (-)Tj 0.047 Tw 0 -1.218 TD (\021\036\027\017\005 \b\017\030\031\030\020\026. \217\036\001\036\027\017\ \036 \r)Tj /Span<>> BDC ( )Tj EMC (\023\024\035\034\031 \026\022\030\t\021\024\020\024 \r\036\007\036\027\ \017\016 )Tj 0.132 Tw 0 -1.218 TD (\030\026\027\t \021\030\036\002\031\036\021 \027\026\035\017\004\017\016\ \031)Tj /Span<>> BDC ( )Tj EMC (\b\017\030\031\030\020\026 \027\026\r\t\022\026 \027\026\035\024\032\036\ \027\017\016 )Tj 0.019 Tw 0 -1.218 TD (\220\027\007\024\f\022\024\023\017\004\036\f\022\024\020\024 \001\r\026 \ \r)Tj /Span<>> BDC ( )Tj EMC (\024\020\030\026\027\017\004\036\027\027\024\n \023\030\024\f\021\030\026\ \027\f\021\r\036 )Tj 0.087 Tw 0 -1.218 TD (\r\027\031\021\030\017 \023\030\024\f\r\036\021\026 \023\030\016\n\024\005\ \022\017\001\022\017, \004\021\024 \023\030\017\r\024\007\017\021 \022)Tj /Span<>> BDC ( )Tj EMC (\031\r\036)Tj 0 Tw (-)Tj 0.341 Tw 0 -1.218 TD (\035\017\004\036\027\017\033 \007\035\017\021\036\035\034\027\024\f\021\017\ \024\023\036\030\026\006\017\017. \230\026\022, \023\024)Tj /Span<>> BDC ( )Tj EMC (\007\026\027\027\t\n )Tj 0.21 Tw 0 -1.218 TD (\023\030\024\f\023\036\022\021\017\r\027\024\020\024 \030\026\027\007\024\ \n\017\017\030\024\r\026\027\027\024\020\024 \017\f\f\035\036\007\024\r\ \026\027\017\016 )Tj 0.301 Tw 0 -1.218 TD [(Hahnl)30(oser [8], \031\001\017\r\026\027\017\036 \023\024\f\035\036\024\023\036\030\ \026\006\017\024\027\027\024\005 \030\026\027\t )]TJ 0.273 Tw T* (\023\024\f\035\036 \021\030\026\027\f\026\027\026\035\034\027\024\005 \220\ \027\007\024\n\017\022\030\024\b\017\030\031\030\020\017\017 \031\r\036\035\ \017\004\017)Tj 0 Tw (-)Tj 0.096 Tw 0 -1.218 TD (\r\026\036\021 \007\035\017\021\036\035\034\027\024\f\021\034 \024\023\036\ \030\026\006\017\017 \027\026)Tj /Span<>> BDC ( )Tj EMC (30 \n\017\027. \(62)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (16 vs. )Tj -0.022 Tw 0 -1.218 TD (90)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (51 \n\017\027.\). \200)Tj /Span<>> BDC ( )Tj EMC (\007\030\031\020\017\b \017\f\f\035\036\007\024\r\026\027\017\016\b \f\030\ \036\007\027\036\036 \r\030\036\n\016 )Tj 0.108 Tw 0 -1.218 TD (\024\023\036\030\026\006\017\017 \r)Tj /Span<>> BDC ( )Tj EMC (\024\002\036\017\b \020\030\031\023\023\026\b \f\031\013\036\f\021\r\036\ \027\027\024 \027\036 \030\026\035\017\004\026)Tj 0 Tw (-)Tj -0.036 Tw T* (\035\024\f\034. \215\024\035\031\004\036\027\027\026\016 \030\026\027\017\ \006\026 \n\024\032\036\021 \002\t\021\034 \024\002\255\016\f\027\036\027\ \026 \021\036\n, )Tj 0.068 Tw T* [(\004\021\024 )0.5(\007\026\027\027\t\036 )0.6(Hahnl)30(oser )0.5(\023\024\035\031\004\036\027\t )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 14.857 0 Td [(\021\030\036\b )0.5(\006\036\027\021\030\024\r, )0.6(\020\007\036 )]TJ 0.316 Tw -14.857 -1.218 Td [(\024\021\f\031\021\f\021\r\024\r\026\035\026 \036\007\017\027\026\016 )0.5(\n\036\021\024\007\017\022\026 \023\024\007\020\024\021\024\r\022\017 \022\ \017\001\022\017 )]TJ 0.151 Tw T* (\022)Tj /Span<>> BDC ( )Tj EMC (\024\023\036\030\026\006\017\017, \017\f\023\024\035\034\024\r\026\035\017\ \f\034 \030\026\027\t\036 \031\f\021\030\024\005\f\021\r\026 \007\035\016\ )Tj 0.246 Tw T* (\030\036\036\022\006\017\017 \022\017\001\022\017, \026)Tj /Span<>> BDC ( )Tj EMC (\f\030\036\007\027\017\005 \030\026\n\036\030 \023\024\f\035\036\024\023\ \036\030\026\006\017)Tj 0 Tw (-)Tj 0.064 Tw T* (\024\027\027\024\005 \030\026\027\t \f\024\f\021\026\r\035\016\035 3,6 \f\ \n \r)Tj /Span<>> BDC ( )Tj EMC (\007\017\026\n\036\021\030\036. \202)Tj /Span<>> BDC ( )Tj EMC (\023\030\017 \026\027\026)Tj 0 Tw (-)Tj 0.201 Tw T* [(\035\017\036 \023\030\024\007\024\035\032\017\021\036\035\034\027\024\f\ \021\017 )0.5(\023\024\035\031\004\036\027 \r\t\f\024\022\017\005 \031\030\024\r\036\027\ \034 )]TJ 0.202 Tw T* (\020\036\021\036\030\024\020\036\027\027\024\f\021\017 \(I)Tj 0 Tw 5.83 0 0 5.83 350.5482 350.6418 Tm (2)Tj 0.202 Tw /Span<>> BDC 10 0 0 10 353.4632 347.3118 Tm ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (63%\). \200)Tj /Span<>> BDC ( )Tj EMC (\006\036\035\024\n, \022)Tj /Span<>> BDC ( )Tj EMC (\030\036\031\035\034\021\026\021\026\n )Tj 0.299 Tw -7.85 -1.218 Td [(\n\036\021\026\026\027\026\035\017\026 \f\035\036\007\031\036\021 )0.5(\024\021\027\024\f\017\021\034\f\016 \f)]TJ /Span<>> BDC ( )Tj EMC (\024\f\021\024\030\024\032\027\024\f\021\034\033, )Tj 0.054 Tw T* (\023\024\f\022\024\035\034\022\031 \030\026\n\036\030\t \f\235\024\030\n\ \017\030\024\r\026\027\027\t\b \007\036\235\036\022\021\024\r \r)Tj /Span<>> BDC ( )Tj EMC (\017\f)Tj 0 Tw (-)Tj 0.503 Tw T* (\f\035\036\007\024\r\026\027\017\016\b \002\t\035\017 \024\021\027\024\f\ \017\021\036\035\034\027\024 \027\036\002\024\035\034\001\017\n\017)Tj /Span<>> BDC ( )Tj EMC (\227 )Tj 0.134 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\f\030\036\007\027\036\n, 3,0\2264,0 \f\n, \004\021\024 \n\024\032\036\021\ \002\t\021\034 \024\002\255\016\f\027\036\027\017\036\n )Tj 0 Tw T* (\024\021\f\031\021\f\021\r\017\016 \f\021\026\021\017\f\021\017\004\036\f\ \022\017 \027\026\004\017\n\t\b \030\026\035\017\004\017\005.)Tj 0.247 Tw T* (\221\004\017\021\026\036\021\f\016, \004\021\024 \026\022\030\t\021\017\ \036 \007\036\235\036\022\021\026 \022\017\001\036\004\027\024\005 \f\021\ \036\027\022\017 )Tj 0.264 Tw T* (\f\027\017\032\026\036\021 \030\017\f\022\017 \023\024\f\035\036\024\023\ \036\030\026\006\017\024\027\027\024\020\024 \022\030\024\r\024\021\036\004\ \036\027\017\016. )Tj 0.327 Tw T* (\200)Tj /Span<>> BDC ( )Tj EMC (\030\026\027\036\036 \024\023\031\002\035\017\022\024\r\026\027\027\024\n\ \f\017\f\021\036\n\026\021\017\004\036\f\022\024\n \024\002\024\030\036\ )Tj 0.301 Tw T* [(Khan e)-12(t al. [11] \004\026\f\021\024\021\026 \022\030\024\r\024\021\036\004\036\ \027\017\016 \f\024\f\021\026\r\035\016\036\021 )]TJ ET q /GS0 gs 453.5433099 0 0 90.1452541 42.5196838 122.5958958 cm /Im0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 0.215 Tw 9 0 0 9 42.5197 111.7959 Tm (\022\t\217\210\b\002\220 6.)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf ( Forest plot, \030\031\003\n\021\t\024\032\025\032\205\007\211\025\017 \t\ \032\031\030\021\031\031 \013\n\023\025\006\031\t\024\027\n \030\021\031\ \017 \033\n\t\023\031\n\033\031\032\026\203\025\n\021\021\n\202\n \033\032\ \031\005\020\027\026\021\025\002 \027)Tj /Span<>> BDC ( )Tj EMC (\t\024\026\203\025\n\021\026\032\031 )Tj 0 Tw 0 -1.2 TD (\027)Tj /Span<>> BDC ( )Tj EMC (\202\032\205\033\033\031 \t)Tj /Span<>> BDC ( )Tj EMC (\205\001\025\027\026\021\025\031\003 \032\026\021\020 \025)Tj /Span<>> BDC ( )Tj EMC (\027\031\030\031\021\025\031\003 \032\026\021\020 \n\024\013\032\020\024\ \020\003 \t\033\n\t\n\005\n\003)Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf -0.022 Tw T* [(F)-16(igure )0.5(6)16(.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf [( )0.5(F)11.9(orest )0.5(plo)13.1(t showing the )0.5(mean )0.5(number )0.5(of )0.5(d)26(ays of )0.5(postoperativ)13.1(e hospital )0.5(stay in the )0.5(g)14(roups )0.5(with w)12(ound sutur)-36.9(ing and open )]TJ 0 Tw T* [(w)12(ound manag)12.1(ement)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\214)10(\211\036\033 \035\030\032\t\033)30(\b)42(\032)-21(\240\033\233)]TJ 57.136 0 Td (REVIEW)Tj /T1_5 1 Tf 25 0 0 25 505.4647 56.0378 Tm (185)Tj ET endstream endobj 121 0 obj <>stream HW s8;!KU<0!P3ع=@8{O$CN@2{zVVwK"6}\$zV.6;\Ce hzhe,VʓPZ1 t -Dg*֧X6T>lIy< 'JDFٕq՞,DDi]g":bg̓qėc}/Iy!¯"JHݑ6=Z\`i~:oTTVncឿd.= =o9hLw<'QۉEb2"| D\Gx w\$%Yjgz2)=y;QNI1i{x"TgusڌxMIX$=0K:x+إ¢H,,,,,,,,,,,,,,,,~.xKU ϐlW]N$2,[ƇT$/ mՇ "B=[9XJR9M0ƍ:`# q;ןd?Fi5BYp=Hډcf\YowZ'r\qFڣawgH6O9*nm" sXpjr!Jɢ5#^dN׸c1COR[0 =u)'bNxi:l5 NU֞ }I(]yEڈ[r -:KF0`{޵0VO"|6Ў%'Aqn/t@νK;VM ەh-8Z)wSLKEt-}1!i[O TyB74$5VriLf.cń|n,_T컬4`\%fNlPx"j8ed% 40/;a<_aNM5f_x$mFV~~SO5Lg\3A(EtK|"MAM{]mJOmjZmШƆv&M܌b5T%BlZX 3.;s\P$Yt)h2-S! N0Tõ09ȡ3sV[3Rsݝ!-p-{F /L +;G2gM[" ب5.!#.`5b9 uFx#S*k'{Mlΰ?S!|Pp=ǃYg0?|ab:0Vf/ă.6Mp7gq„<œ].gsDńW~\=R:'pC2CErG9g*' ,.& " /yǍ^dΡ1A+yH&Q 䏧/\[>ۉSD$s9QD[ Ym(40T*d5\W9wU)*ω<-EcC?6(Q"aQy9|1r8E"zc_|=}*H#>DUˁڰ:qT$򬷠%/8k)2ޡQsu`+׆l4>H-pYI]!Xs|܏^L.4ޣ^LOtlxZGv] D>!{?ϘrOCI/J>f"C#ct3{蹹+h Y`5WJlD'R_b?OBx2Hr 9.G0P ;Aq`\v-b[|GS:#v˝ s\,I{]b$ye,(w\+ؿǙw0PSz5UCn]gj6%=2&n5dtFrz"dUBꑿ9IA%Ǜ8g M 5c_`M!.56b鋤^1dX2:XRŝ"X0k{g[Ij6 ʭVs${>`sf :!6xŠkʝ,m8jE1oSF1o(Rl9't|fXXX[E xk,,;XXw x[`aϷ60`/ޕ*F%U>c FI8HPZ@Po]J:tuk$5R@?rs J;4I C `ѽ^L^!)SiŶY}#'L{~Ktmp8Tjt4{ V$AbAv}E(?}{DM%BSڅ0֝uAvqlp%&_/7;]5:DeRD$m.Xt8$LHX_q>FP %leіqScS$.i8 1'1SP <ǝ}TCkp ITkGSAlr0b$e$n. k2Sɮ%tj;Ppoئ:x@iE@i Ё0CJ `0` (-:PZ1tc@i Ё0CJ `0` (-:PZ1tc@i pU2:ab9EڔcpX'Uh9j ntѐdɗUl#x<ֺWwدC9߿5YڌԱ>_bE흫3bo_ּ˪Gfȴ\~UYO>e3&1ES^LPh|!.p+dYMK{QŽ V x~OURY xz~ <-. Ϳ*b6Ͱ˵1-Ne;%?=WQ=\zOGf*joi\Ȟ=buH?2Ќ6UmX-ns(6<4ut"=n@m{u&_GeۂO`^%L˱R3*H>iOFG%S$Hp< E5 A9;jeתYWy=Hc W혎 V|dh]'BGOkZX (" .(8Z};yj&׸K[ARfg`܉v_~١/ ; $Ui|V6jL Wg ʇ 58D!#2 k96 }=|d܈j/XT% ordZ p _ڻ3$ f*K'Hȋ}Z$pɊniwgj0;Zۯ@ք!Tj8A""J`AyG+f]ʏ8A2+xXaXݥ%^WUF1ŪN-p޳u7,rl\TR9$y6CpM}fxAW̿ˆd$fV$ .iq۹}v놈R2Ќ1~|~9A2!ٟd?E= '붏U]šv |&=:T_6Cu%_j=՞"x"+'iyyA"4hΖv"OFe3&%OO$DJ =7E2Vc&BVl{F^e0:Y۴Wp6``PZ1tc@i Ё0yA6.Wqώ6v 8N0%mΦB$j\i£T{68=;{;9W]"~ikt_֨[uHA61 ͫlJ M~=KQU x|ITiFAbI{%{`(G_FM0o"@ mM k_m6w"^;tפeDO(u/9o D 14`"! Kbɺ(M]gjn4)>pP@H(5s?H^`H_EyLn$kЅW}wĕKB2y681|kEV YNQEbi'I\@v~lBj Ф[RRzЊDJݮ["Bf+/TEba[[A}5q+i 4)>pbb&3j%M9lXueBM5ߢ0i cczMf/X>RHO^[WFWyP!- iF{&ҾaL(дHf i_fO4<[ɳ@# KڤrQ.IIkHvXV\[QgJŨJ+ƑݩQHL/X$8KGVyӎJuYp6o( }p#' MJ*Я[]`y\,C9?9q#gˑu 1\I4X"MjE9yfxwNV#.M6/]~_@A 8G+a3𖩒P ?z+h SW OMO'\N:?\D)^&Z }ow>A;b~Ӎ;ef :cݸْާTef׿"!n.5^@7*h/ݏD[+r*h H+#Oo%gjE~}Ag7Zk\]\%hyvG9i(sMr>Md3&< n+6;~5ɇ]/0yrEBWS=MM K/0w 0 0 0 0 0 0 0 P+Y@ endstream endobj 120 0 obj [/Indexed/DeviceCMYK 67 198 0 R] endobj 197 0 obj <>stream endstream endobj 198 0 obj <>stream |zyxwvjiWVUQPO=<543,+*&%$!  endstream endobj 110 0 obj <>stream q /GS0 gs /Fm0 Do Q q /GS0 gs 453.5433226 0 0 113.3858306 70.8661499 609.3041108 cm /Im0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 0.03 Tw 9 0 0 9 70.8661 598.5041 Tm (\022\t\217\210\b\002\220 2.)Tj 0 0 0 1 k /GS1 gs /T1_1 1 Tf ( Forest plot, \030\031\003\n\021\t\024\032\025\032\205\007\211\025\017 \t\ \032\031\030\021\025\017 \032\026\016\003\031\032 \030\031\f\031\013\024\ \026 \027)Tj /Span<>> BDC ( )Tj EMC (\202\032\205\033\033\031 \t)Tj /Span<>> BDC ( )Tj EMC (\205\001\025\027\026\021\025\031\003 \032\026\021\020 \025)Tj /Span<>> BDC ( )Tj EMC (\027\031\030\031\021\025\031\003 \032\026\021\020 \n\024\013\032\020)Tj 0 Tw (-)Tj 0 -1.2 TD (\024\020\003 \t\033\n\t\n\005\n\003)Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf T* [(F)-16(igure 2)16.1(.)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf [( F)12(orest plo)13.1(t showing the mean lesion size in the g)14.3(roup with w)12(ound sutur)-37(ing and open w)11.9(ound manag)12(ement)]TJ ET q /GS0 gs 453.54331 0 0 130.9442627 70.8661194 435.4558837 cm /Im1 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 0.001 Tw 9 0 0 9 70.8661 424.6559 Tm [(\022\t\217\210\b\002\220 )0.5(3.)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf [( Forest )0.5(plot, )0.5(\030\031\003\n\021\t\024\032\025\032\205\007\211\025\017 )0.6(\006\026\t\024\n\024\205 )0.5(\032\026\016\027\025\024\025\002 )0.5(\013\032\n\027\n\024\031\006\031\021\025\017 )0.5(\027)]TJ /Span<>> BDC ( )Tj EMC [(\202\032\205\033\033\031 )0.5(\t)]TJ /Span<>> BDC ( )Tj EMC (\205\001\025\027\026\021\025\031\003 \032\026\021\020 \025)Tj /Span<>> BDC ( )Tj EMC 44.197 0 Td (\027\031\030\031\021\025\031\003 \032\026\021\020 )Tj 0 Tw -44.197 -1.2 Td (\n\024\013\032\020\024\020\003 \t\033\n\t\n\005\n\003)Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf T* [(F)-16(igure 3.)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf [( F)12(orest plo)13.1(t showing the rate of bleeding in the g)14.3(roup with w)12.1(ound sutur)-37(ing and open w)12(ound manag)12(ement)]TJ ET q /GS0 gs 453.54331 0 0 130.3490615 70.8661194 262.2029099 cm /Im2 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf -0.022 Tw 9 0 0 9 70.8661 251.4029 Tm (\022\t\217\210\b\002\220 4.)Tj 0 0 0 1 k /GS1 gs /T1_1 1 Tf ( Forest plot, \030\031\003\n\021\t\024\032\025\032\205\007\211\025\017 \006\ \026\t\024\n\024\205 \032\026\016\027\025\024\025\002 \025\021\f\031\013\ \203\025\n\021\021\020\004 \n\t\023\n\204\021\031\021\025\017 \027)Tj /Span<>> BDC ( )Tj EMC (\202\032\205\033\033\031 \t)Tj /Span<>> BDC ( )Tj EMC (\205\001\025\027\026\021\025\031\003 \032\026\021\020 \025)Tj /Span<>> BDC ( )Tj EMC (\027\031)Tj 0 Tw (-)Tj T* (\030\031\021\025\031\003 \032\026\021\020 \n\024\013\032\020\024\020\003\ \t\033\n\t\n\005\n\003)Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf -0.022 Tw T* [(F)-16(igure 4.)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf [( F)12(orest plo)13(t showing the rate of infectious com)16(plications in the g)14(roup with w)12(ound sutur)-37(ing and open w)12(ound manag)12(ement)]TJ ET q /GS0 gs 453.5433022 0 0 96.703123 70.8661194 122.5958882 cm /Im3 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf -0.014 Tw 9 0 0 9 70.8661 111.7958 Tm (\022\t\217\210\b\002\220 5.)Tj 0 0 0 1 k /GS1 gs /T1_1 1 Tf ( Forest plot \025)Tj /Span<>> BDC ( )Tj EMC (funnel plot, \030\031\003\n\021\t\024\032\025\032\205\007\211\025\031 \t\ \032\031\030\021\007\007 \033\032\n\030\n\023\204\025\024\031\023\022\021\ \n\t\024\022 \n\033\031\032\026\203\025\025 \(\003\025\021\) \027)Tj /Span<>> BDC ( )Tj EMC (\202\032\205\033\033\031 \t)Tj /Span<>> BDC ( )Tj EMC (\205\001\025\027\026\021\025)Tj 0 Tw (-)Tj T* (\031\003 \032\026\021\020 \025)Tj /Span<>> BDC ( )Tj EMC (\027\031\030\031\021\025\031\003 \032\026\021\020 \n\024\013\032\020\024\ \020\003 \t\033\n\t\n\005\n\003)Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf -0.029 Tw T* [(F)-16(igure 5.)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf [( F)12(orest plo)13(t and funnel plo)13(t showing the mean duration of surg)12.1(er)-43(y \(min\) in a g)14(roup with w)12(ound sutur)-37(ing and open w)12(ound )]TJ 0 Tw T* [(manag)12(ement)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\214)10(\211\036\033 \035\030\032\t\033)30(\b)42(\032)-21(\240\033\233)]TJ 57.136 0 Td (REVIEW)Tj -57.136 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 23, \023\0221)69(, 202)69(4)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 23, \023\0221)69(, 202)69(4)]TJ /T1_3 1 Tf 25 0 0 25 20.8778 56.0378 Tm (184)Tj ET endstream endobj 115 0 obj <>stream HW͏?Mb-\ESPxI8nXai1  HvE$#SǐQvM=?$^~{(‘{׍Ց$*8mnuaI-n~`j^BLmpf/3?'ҹ#:/ ԽcQO{%Z`M ,fL֧SjkO}_qM?X*ҙ)qA(3bOiGLG ;#D|*0/Pd=3Lk@V~8`X1^Rݦ^_j;N.РEaN-:`^mGk:ى<]H`4b J]P~)? gGbFeS6*@~JO/Z! T9/hA?K(`ӅsEYiMDNjrt:˚NMot Mt&NjҡvItC-錈{7Wj$[ؗ#_(4Xm2aFuS<SeQ`?xJ߳ 8}c=$j[ c@-_hs|?+-="O[H! t ZCk @K_R2ز0^jy_NΈ$;th]rgTjo*nU2y1#_zvX ڂ Cch_2$^0d3uN؎'Ea҉ѡf:&:8ylڤ?tN2//yW ZlTx K}_#Ehp.t<'5$F'̗hסc&3(9 0聇Wmё-}:&-QpxGU Mm3y(܀e4#gJf !C ?;VpuU{S!qx "d-ECUq&'O&Hqo/KMu@f\4ARPɈ]e\ GeΣ SC L4_ս;)as"[SץoF?nn}SK'Zl7^W[8M{MMo(ڽt}_?™gBi ޽6ѱ$[~:;6_OKQ x갴/`#—dG9FZF[:3tyR3TMn'I<11m֙.5T:% T^\x3;qHT@bD>Hқ/OLbK{ϓ ^ z͒= 7 1kv(WBm_`  ͂@s2x ?lyBHfgu%jz}_PZ5 LS2m\iEi_ D^9%a(eu\󋬟DAWiKbKbV@%a F OSdb\4a!bXsdaFbcAL6C1U ^P!2zM6lRVDN^ h( /dG DmYKA})sMKt:_ &iLB5}$$K"1QQKbR aBR7f*)fѬCjk4l`X?-}x)9$vd\+mR7 nJC;xמ;y?꒐fY_uIBg%a@Jwr#]C`y s8iԤ2.ph6yPQhdJ9 q/ʆh!C}HwggB2؛/,.(~k-P8LOA%k G=&73KL3dc f"lt8Jk*p+^҄د1C)m_SĮC"sTN6Y/ՉI(. Rq!4.l@vzw 傌!Lހ т^˜p kQx e uY|)!t[ Z==ݺ^0HеTLuVkr<-Ή2J$rM27+~&k>>d ?c4Hl:$&Dxwylֽ>3/GSdf@yDEQ> 9wae{+EtBdJ'l|W Cjap|x8lXX<6_,,'/Bc()]ߟp=vsWˎݸ) .&@6Ydh; {AA60؋'WуX|t`wJ"QUU\1iL|5- xAzH W.˓*9Z ~aIwZypzvF:ҡ+(l azA{.t4 1%ViMDV4%5f4€KyP|ҭxZNT%-jFX0nsv=s}dbŖJw #jOymÜC[^9 Yb.Uf8'{ߒbnX1]i^@j8R/ F$5'c1#4eOUvWwy`2+Riw< }q"^o?cP ՋB!ECPȡzQ(P(r^ 9* }!y\] k|/XVXuN F.Sf-9w[9i4M6fL?%+.3-JYd^V7X.+CM v&zw&l]D/,CSV ?l uQ՗UzЀbOSjz"H#}6^]yeJ@R>ElXewdq-%RRX-Qn9kx~vGl&)M/V`X^ހNpg&</B^PX_ gt§d:AiE ՗& ֤g\ ,LtN.sbV/dJ Wg8A-GD/߰P TɺJk"ZPU؉6ЛR~ue/2̺kvE ‚q+QĴ^NsחR< |եguULO +:B EP(r^ 9T/ BGGH/O&srn[KȬ,hǭ8)3k3MBf;΍h۶iۣYDq^l].00pHr<d]>=69rI/2 Mt8Eq6nT`r;Y.YQ@%#qSI:Q/^LhLjpՉ+0Wa<{Ls!r CSk,L3)P^P6^jEa yHƪ/X1yКM|֋ "z 5ωv1]z ;]!#G- @`_F٤bʏz!73y7iQC{U0/RKj iI:K_af&@/ cE}7R>BEBkdX"֋£ /BFrCTi", 2CU|!_ds ޳ =؈EoW%@r*0\$nL 4x N2eܓO }6%кX_$zI//Mziox$ \^riP= }"HNfhALI`ϐ*K"@Q!l0XV$v _ҽL9, L K}Daڇ7b#XZ'Uv_&'1hA0k.EP%,x@zQba%c3#x@(bmyfX)CPȡzQ(P(r^ 9* ߌA{ SM% (c35FN HA M6~+.~̪&/^5c`\" /c\/\* tgD6r\l0Śӟ"^ƠJ@W]}iګD!;[?u,L1G%'^ŃjC_ąH/xE895DosSR([Y4YNlD/D/RTbl^n4MUJΩ/"rlH˨Tw\/U!ܰ^j%!9z.qؔ+YpBqVp$D^X1+P.3di36BZL/W@Cgjn.@&u]*RdVC9JxxBG" ~_]zVGH . ) E*ۻ1aTGHBՋB!ECPQ^`@+9"y ]#gY0E:B nӂoU::5,@2O0`=.1,.<6>F EP(r^ 9T/ BՋB!ECPȡzQ(P(r^ 9T/ BՋB!ECPȡzQ(P(r^<;{W(9,?^$5 zrw=P|>Ϯ WpzC~=kGo{~yoQ|q}7p~k̟[/y/GO^:7'g v/s{qqzEYt޹ w#ہޙ78OV>>&?η7nܜ~y{N:~t{'~?ݖs5/6XǯTs/f؛ۧ~yz)#h? qy:嗁uC$tz92(]'ЋajFx6[;/]p:A'х'G۾WKsE>ulJ.Kֳ_edV4~Ze@f?vya/vȈ::r/*Zb)n,X M]"c~pg6lΓo`1r)ߗc1Wz8R/u@6:rOkG|Xw}24~GP`-}ɓmspW]3ұ[Xw)ڦ Cs'fe|q9{O ~c,3 :?І(jUUuTwBA>Zڐ9(e捧՛)α_j5 Px<o1@X-h4 J¶N_.6_V@;εEGخجE+,fQdCȍ %D2kSc>9UՆCh *Y< G?Z]+!Ʊ| E|!4rA'(L@aN[6cM0a0>Ҁqu tFB9,:v4_;Ng\Pƻ Rl;et?e-s ƝEL馬!,Eoܢmw&Ee2J) a?⊐ucIC:wҍ^G%n=~#aXWs_Y;#^s>'hO_<\*# a#!//@ @  0+ endstream endobj 116 0 obj <>stream HWm{8m:ShC;@hklRE͕/C D ~tu5cgt]4 ;%.lWX*>jӃw.^Y-tQm: lDdOlʄmC/k+VMI~T(-||Et QoC76o~ ]m(8:QZ@[40ckJNKJآYـy p/px ő<5r-gt("3]1և އ2"Cڦo) w_NO)uA>w'5Q^%VQu6j^u9&taW>yg}K$g;tXWOr}Ruwӥ{1/JGtќDB:^7{P/qW[FvYIeDHE^$x<8lD:bSæo\C[W2"AAgtڼEbOBuF^+vxaWU*|^3~nT:fE\#[< H}LdP&^+Vp+&aw1۽ .i}ja9+YI@?'R'J@yj}JU['c%t tG83+a).@mc=B{8Aޒ- ,L/~6i[{.|bVEDâ(.X6po9o4D$ЂsL3{۵: ۴{ה#r^5 DON;ecȴ(C 2כ\lݲ@aD7-s ޝ{@"L%HuJ&#|ef.ouD;,ٌʷ@#G<=c }Jg8aF)2o]轃ሎA6lY[ŧqa1%3Jk`Ouv^9̝_P^¸߶?yv፷ /Ł#0hbv5 SK`rW/pI3ᒌ`=/]P"GKw~ C*j2J)-v|N^pzj#H/,)bDa ,yOoR{ ?W.zC 0Wl<2Qh|ؒI+ I?˖66d·׆O0_1D~r-baxlc숧_c8%|MW.&31MM'ZW%RN:_lAO?kuDdBCn`?coU adR.$Byj)ۉǾҥ.^{^&2,@V%;t2#tl6Rq9]n҅tJU)qXM+ռ:bL}WZulUՋsXƔ*d?};^bNMk'HݭO' g OeԲK~Kul6~v""E**N$q({;$&Fs+V0%tE&pf%85JxSM;y[O(&4`8$)hjj )9?'!|=0 XD3;52~FrCrΝGXEVDh߫VD&(JF/b`-ou~&Cf3Q;>/DVyƫK!8Yn74b VJ4h܊S=ʙ\\Vb&*M^I O) }jK̵Vaͧ5/,'srG6I]OD̃OxW(O~ߍWBڴ^3*0mk }p&B <&kW/48yzuCguttf\ҌA S:-KvPaeG>t* cbD̀mQ0Bܟe|k84>|iE&/)cאvƪG~Zܪ#4N8ɶ5|M֛լ~ CqMMYLq5,GԶ/7I4ֿ*ϙGa2=!&[!v7˄)Fř(q).{C*vr#~L8UᣘD'4=tޝ"zkU}f(?nS>ٔtx*QS+C鴾1Vc|e)GȎLuU^Cs.{/sKs)4QO$J?|(1>PVٔ/|yDCrΗBOBIiDXW#r%r~*~P_ԻgR~JoE#GY)N|{V9bDMğ/?R8)?t+?=(,T#:ŵL_䜹u.3+2f6Μ> G"dJhZ೧ rT_OqHSt2C]`-\ `3d[Z߄G%{xh9DZÿ]eZvH'SD>i"IO2&JE5C1}p*תU) X2;@EMѨX,b2gO C7SIf;Z*U$0 ZݼbpDoj" 2"N[Fk9<ȪwTSTq9 Mނn|M|mD~riËЉP8@ے|:]bovDh.~_u/:1ߔC&!lxN;`Z2gO=ugp3v8uoxd)ɏWv)Œoۻ@wb)#;Dro1k:#Pua'apL+D~991Vs*ٷ@uª{l}H3"DCuj֒dZvuq7!Rl/@!iy'SD>i"IT'Goti5CyO^ k:du f^/rwREXf4۹rMb6Q* GO6T ヶ("Û _$_̔#[!rm@YƷ_ =GCps5g^ld..fAs1w3 he:>[#>(':*`*0?ԄwBw';K=fk#CFo-wz}Iyn񮽲 nnXʊ@u0lZO9?Y9d|UΌڻo3| LkM>qndR¡|6$3s1OyE#ۮRBq|&ϩKb @T_*iVo[&@ML #{ yOzG);вsi"IT䷺"5Om8˩HZabˬ0b]YkENM:^l+,jNw*#$b ;OtS," J,¾ rT$bj/ ˑWY_{pa<A F7?!?hU{1CZ,8!ة8ě:XR>+Y1kuҲs+ p?MőjUo"~} _L7)A1d rQv)vv'NNŜc\/GXS9Gi9];@vN>֠_Oti:;)V#TlCF ܃W\)zˁj$Y;w࠵ tU}F߼Nh*Uk5^QkkD`q8tJwڲ>;Q=릈r!ZFV7wzFk ~I~n\IH7VQo5ܣ^YvM>O!Ѱ9K?mAV70vÌjyo`@o2l%|gRIk yA>ι˒t?;/F!"Eȷ";Èt+ z[ǑՖ*v LM~hA"ȷxM!#I(~`ljOq5ߟx(f"sꦂ GZ'Z@!RfOve)3Vv"&O|TrWh V :t=hƽ#' ͳY.WqERJfG,2s^͠h/pcJ5[X]eW/J^ECPEުS "iYF~IF\UQ:;Yc ``s6:$cfA=5wXH~ ^{(ӣ] [,2EoG~pG"eT }AI(ЀW/^ gk[`;'H17!;вsHIK!99.0wQ3aZ4{@!% V83]v rم|me@!%dmUGY9 Jgذ޵UJwhDM`fo9꯹|[e7!R1 RvH'SD>i"IO|i"IO|ݲ)Qǯ<Wو}e+s@xQWx ^8|`!VG7˗|y/n8k8_fpl{>kVO񫷎-7eO^wOre}ã3Z9 =KŸd_V |1ݖ'">@-+MñZ+q|(!$ 叫-1*V_ޠץ#/Wi^QꬆfAًF>Ϫ屲e]_h?9 5x^HUPV͚-è3(ou h^Ŝa"j{sāe!-dxXsq Y>#aٔ,5`nWƝ/.|Kq}ߏQᷲ3[nڗ+d7N벿?\Ǡ7wp㵾9\Ua?s _j/Sm[C?u .2&L?l}P~NPh]_O+~'[<_q05@`-5i (YaYD_$cw%QG_sETKޖs,ʶ;|l`?f~=޹2;`]`qM^]sw=~ù~ N>XC۫έ|`\wq/u{Q-șnUQ?).|^c_+M=]_mcA~O}嬺(_٧K4FFi2M˔oZ|2e䛖)#ߴLK> ޵~afV+ ٜQt eеsU Ћ r ^Ls+4$b|N0qy礬Z_ȓwV3Ϸi{5*땖Cp@>gTNB~/9)> (v6q4^|`_GsjLGP lgM0v2&![i2e䛖)#ߴLe7-SF>'LOIٜQ7x 6PK4JJK7X4m䘉g_[|I^e ]N&_Q"¢av4L`2x+֨e>acCW-կ.Dؤ yȞb{g{^|Μ秭>H,:24oYoKP#I5Hh4?D'WHJ{Hq 6Kȹ,Խaݵc*paW䣼mk/%C! z/7F Es ‰[lD|ދ6n[: }NvP g47L AS<*O*+—QWкS'DߒЙhe;جA}qG ĀmھJUwN}b>oCl7u-a(yD`O2i `=rjгtbnK}T;&?r\Nˑw xtlvuꩆ#*=bFb33#PiF[Nn1Sgm\2M!fx xF2e˔o/SF~)Ҍʁ^\JWחXZ&yf1.S߅ڋiiT [h]ϲ| ql-6{dVGH_T^"DbX׷n8`{6ME!16̈j= ^Rc ؞2Md |g5}Gƣ&e(ȓB=LD1"OC $I;£J8YX7=L2FjNlIc~,Jb(j%_v(YlU}xl]g^xyӣ6$_^GɍZf؝Y0򡫵iV׈c?w9#ߤ9>ۉ$ѤvLS4h, Y`A~U捖tV8-{?nW8-lwRZ}%p be$ Υ]y)ny"Pqn6l\vOpsk{o--l߬5 Q͘=qߴ}{{qu)Hf I~saڬL|%>stream HW {8]J|K6pϳ}6=czB(޵/ٖ'q7zhfj4b찁oRA֍*)}"]{fhoׯzͫ}v$sNkL#r 6U¶#a`sٴWQVIhq+^Y0`,=ҿM@7UBקD &%.pV’p͘o''lMmlA=WX% cGy:l-j~ ;Kq KJJ-F~oPL0U4D6wczSDXNsOsܽ ϩOu,yv, hI1n,ͨmP'CuG i;mbo@˖8y櫭'8-A(Q8ň4 %PŃ5 hӺ7ߝ+#|*WPS]LV". pisG]T'˫ԝ)NÏ,n0N|K%OtR|%@ ",WD$66U,9>*p'tDivaAGu2.A_ԝf./l{#tEH|o-~d@uI7XOyt) РEgmڱxȧ –)l/5 < 7]Np; w&^2HCˣN=aC+dd%⌅ N< h6YU[i8Qk{Dk($s=)}ސct%6Zk X(`ńlY;|d WѓXw0_z2ƮVi|(š-i| [9A(-iR?+9E%1LAV=I٬/|qWw6Fd-QGl`f@>'mmR6:6ޒsZ50[7\م7^S-6?G!lN(#,JZLMpz KaϞ._{JhAU!kkV"A9}Mya* mʈ^nZۿ1my ("ƔR:o$'FeD\WyvG'"f+zx\\ҏ38MxxrIx*[.?'Yh[V&LzmeROm*vp%M8Mvb1fsNx%r.uϞkԵSd;ozbDyWB_HtKLIKn"sGb ۇL'Q;VdNҁx:v'k K3g/wJ#=&v|y~拢̧/MN*f{ۀna 6YYYa)0fmnGV?|x_d>Thl$h"OEP\^+UcLU Zm,/~e_08lő>$Ħ={P@Omhǟw7(|&귔j왛ֱڣxӷ}@fZ^#wbEd{]ht$kVC^Mۦ_S.$0%z(62y%`޳1?ą/6'>vux<5.Hmr͝$%Sr&}0LDnFrGzպSUϒD&qL=D_DVj%22P]ndBluO{vdlE#DOG,[?R9GzrueQ\Y%\ܶb$ "$yG@:9Ÿ0qeGf`Su.3}Wк(Qwntp:_| '2i >I#nQ[Oq]{@ gc=I%u<"^%ܽv=l(i![=oaQEG* !v>ڏN$q:v4E^C6Gۛ\~uA/EZ-Ư iHwws[\HCR9]i̖ɂ='_{Y/S\Hi'i_(ܠwK4U0ZT'\jP =qȏ+w;Ԫxiw]AN~+X h<0~L,6|tH{~O4+^V쾜=9oN>0Z߳ ˾t|[#!^a'fŐ\L~û=?ر.K~=!'ŒznD-ۤ:GF>Y);CN-7>, v%33ꘇ*/jѨ@Y);CNί+&h ]ozۛd;g$G=v~/9q׸@ΐ(O@b(;в3$SO DHSBhE/2&/=zڻ94V lz+øqyZYF#T]c%nh\.YfUo[=݅cYRi io?H॰>ܡ^w;/(Syxk9 FZp=XZ#f7zuHԡ(Q eZvDy*ֈa/);C"(E/|<%)BRh\Ng@]}61^T1Q 7*}\nY#<ʞ| tBcqS&%L%O >Vl@++1ّo;䇆9&*{0\d],œ ^ 1:/qT\ 1CBoރaOO#c`z"H?,fIF$xIDDmBubj~S|xpLN41t-Gәy3?M'Hn?VDm/{.v]'/z/6 |~p3%߷{v t"7ȝϒ|KOC~pdSD l:oJrs)N.gdsAjTSDM 8f:}/*K@ΐ(k^A}#(;C"(E/|<%橌hC +<4ۛkGmÅ*d<^+"+eg$QWxb=2;AUз7`;v-yN?M>ZI+}袘5>0%!g<=I|'58Px6gjI7ߓ+=bC/u_E xcLGTfp- ;iHvE~Χ%&:Uj'-ZWOvws$jw+3 ّh{`D-ﱽTbKrb 웗ޚ @cFPp`߶J5 9ܓ %gYWc6¾&$6VJ" dbO(ѯ!Q}}"egH$EBhE/|<1(~Gbn'Q(mcrYꀎQۉy5rOCʍht ߞZRjCD`VG':9(&ܨ䓇ηRuZ[^dR~,5ǝխئ#F|rhy6VG1G+;CN'FfۤLz2t4m> Uz4@ΐA๭΁|*jw';Pn]Z!r';CN޹+:ڥB8F!?9 5h8d Y*1;G2P`xDl#G[fq3Dܖ7Aߥ%opPgQIvw50+AkFS_X缔#h yJSBhE/|<%)!_4O yJSBhE/|<%)!_4O yJS;f:+"ш2/OzWA9|}w71UOȍڮ I[^_q[zLυ3':c9gNyb:Oj{nz7[=OE7HZscz Y<l\ָt{哙SퟪuȮ^N +wku1Vh~Ԝ_=^վ _ NpxrWཞs%67:9-%WvoY?LnӳQU/y]/qo7h{4nڕʋuV矧,|l| 17ћ粹wy]u]q7d77}x g8p7I堼}0NLV;b%vɆ>n'Xf ٻU[ղi'+-gq7IO8gFgtO :ϩөJnwEF$ qDR_/S,<׸߿%Fךݮue ~]Iv[VCSQ`+QB~TG>t_?|uh^] Sm+|)~x8?&oSجɯ3x1zB]-+]нŇ7uT}<}+rO:P`,֛O6::M9[oYRks+?a_U7PEۢت_/Wu෍f6|\bч/N&)2[멾ߩ_Å%xWgl{۶8oEXa/R'vC}O4yڲiHdIO䏧̭oxyECd)nS|2/ \3(1-i&s}f۷2T~{ẉ̂>aD[oc-$Kw?0U*[4B49'e=upUtA}N4,YY){g="@s¹z#kI J?ye=!*5M:(%Tov| ڇv6oA\#?pA ?83e=׮ym A%ԥs|8)%_5N)qJW\Cl$)L,z :Ewix{v0u?Mu"d ]AL`# AU^,fU9CEd LT)ٕO}RrGpPxɯBRNV9ҹ%7pz5Ó8s?q#x PFކ%2;)mA]+1Nwwʐ/%8hy="vlx|Ew_yY4RIVX]1tY τ,•Htj'9AdԐIR/Aڗ(Xbs3j Oo#g%@@g77#OXA]d֝ټI MM`QML b"DH`Z#r=DXa6Lh٣#%_*zyuޑ<Žfy`#PnBOFB֛& ?a6'TPC_%RqJW)%_6S%=y|0*1-Hm^@?M]'[f@>J ѦTh7MڮC1Ȇ2DiTH)d-.Cwקeq@t֝|KWuP4(G߉Q~FeOX`@_T G[|lg-]GƣfD>ЁS_lRQDi|ߒqG>'%(~& %_Iau U;'H TBgRR1L3oXV;[p3jF' go9T_a{?McOP|>NkuY;zLdofqC jS24+Z|e\bK;stZä0U?%p3ˍ`$ {Kg W3_`+= GhM83W cu"T/  妯7i%FN7R4T,|!磐p7r>DJRV@eUU~(H]<u7៪s5_UWJH-d%'0`@Ջ)>stream HWiSH>m,CwK+-L]ޭu|YY% R@{}>{XAsbi7p|D6dk/cyd[7n-,;XQJ50Nc֛/d`&Þr7f;P&n*#zyDro9YM >a=i܅ՠ4+NhZ:2} ǼLڣ.`mzZ*uAVko<ӇƷ~zX#@\nU^炞~iEF3@[-PCĝxOdzrh(ˬ\ż!݃e#B~I"Cw:^;ٻiiWl?^<}0ȧLk'lX؇CT ªkEt1{BOyd1\@EtM@X$*S'X1J؈LЦS匚x_&S>fXC-b4*&LQg)bx)Q忔![ϹYL6xlI9%(zh٦EZV4u3t|(:$N8KUawHl?M< %t^xI%sAQcz q#܉~,lTwسAb6T_#q ˖_c>qZ<3|C|,YIA8O*$mFSUP.݈',h)BmzZ!{."T\+3"6ΡߙAQq|p A\#)]|ϒP7E \Y連!.yؓ(!:# !/Y2mژ aA3䑪O4Z1Wf!Agc?1PUş28hЩrZo:Ѣ!""!EzP'U}eHMORa'$kY?eqːkXSAXzɉ\سz"~[iDkdKiá`B )'f 5ET&9Gh/w!GAQVĵnvf zSːh8bؔTIDz=Dftt?2DIǴ=8LDFRM,Ne }jpfnߥ΋$j!OSo+EXhct勮|3/s2$!1hӌiO Q|ꦻK?=?Nr^gxsri +.p? %WiHԗf lJ FuD+ U\ƿ2Hru]M y kw#>ļpB͋:z/}'җ}ad7KMƥi߾GUAtc.L}L uVD h().d/"| ;z <"vhT|JPfh#^[ԒSxAѦ{3nPsYt"ϸrUO:' ^|Vi$Mm^Mb ~ιv f&lKz psy3D]E Ц"" zuFKOcl"fM=nx ʀW ~$Vm>Ȟ_SұJ2i VotTkFLh|{Y N 4tX(O&oǪ # 6j`PmI6ँc``p 008![p4[i_fڠu+Ys@hVlFUsm6z*Lcj{o'oggy fV m鯏'ƙtojqDZ+JǠ?Ҟ5[ӻr-8-[l]\`TA!L7u Bk 'v/VB%Q6 LHۡ}MsfG~۴s*{BiMOuqG;R;-~q#AW$ † r#AJ> ن-n|ts] G ֐]!ٜ 7 u23P}Ob9do}c=,_Jbu_9V 26!ozVxSv07Gˆh/-gA1-I@_~p K6$fFfhaK#!V=Ndo\h$/P 11hBHOK%""$5ʲC S-hKa4H{UF7vfY$L)jRG *$ȯ2噱C gT 8Mdki8 B.^-yf 0W6 %915l*JG`c%4.f i| B TB_Y!1(h608!!C\( _YWr,79o)Bt yi+(%1c%H/qzbh)W5\L€"@ S 6_&A )r$)ip8:-$@4IsX30KevT\DkN+~X("<(PZ@WBk~{`n'9&0FVp.v'"HH"HP.Vz ād:pQ](-{dmC (-#X"eG(-b@iJ 5PZ@EŬ񺴀ybqh4gƓ%DL_j9 5 K󃹠LHwUMtERZGa=nT5p] +>ȃ|)(aD΀1<1cHIHu"&AL+m@dFa?0]ė3+56[n8y" @WJp @XqCW2Q"V(pu%r%zVֿhU)ޜd{K ۡL6)I.Haa<ȲBGwbk׵-_@rBw O5:7җHZks(; MVHz:v;[wCnq*dkzgj/\0)1uj7+fVVsy4&f^/\=^MBb^շ 9X6ChqZպ+ ? 'k;Q3Erz`Նֶ#k!$f֮\liTaΊxP!j9ʫc N?~yS5 qH:Vw$!5ӻZ5 ŁjabTEQ. 5:E9k0tr` (ʉ@Ϣn\AϢnzIGEbR6ↄ.ܸbYp@ XQ!azږMP)hгAKԦYr"99bXMH4J!*G_EBt6A$>W|=/Cy=[`m~ ybP!P<-(go hhF,1a̜YHSd*HJMr =vг J+nV $3e #BA4&R!dBOHгocȒ k)+DzixgDeG< [C$}KC zu#-(TCB)9ɡ;I \OY~ʃ<'zu#-bf@62Sc4FG>stream endstream endobj 203 0 obj <>stream |zyxwvjihWVUQO=<543,+*&%$!  endstream endobj 113 0 obj [/Indexed/DeviceCMYK 72 204 0 R] endobj 201 0 obj <>stream endstream endobj 204 0 obj <>stream /..%$$|zyxwvujiWVQPO=<543,+*&%$!  endstream endobj 112 0 obj [/Indexed/DeviceCMYK 72 205 0 R] endobj 200 0 obj <>stream endstream endobj 205 0 obj <>stream 100%$$|zyxvujihWVUQPO=<543,+*&%$!  endstream endobj 111 0 obj [/Indexed/DeviceCMYK 112 206 0 R] endobj 199 0 obj <>stream endstream endobj 206 0 obj <>stream yxwvpnfdc`]\ZSRJICB>=8710/*)!  endstream endobj 106 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\214\016\222\025\221\013\006\001\025 \007\220 \025\006)-10(\026)11(\013\r\007\205\026\216 \002\013\001\215 \221\002\205\024\025\203 \n\220\ \n\220 \221\025\006)-9.9(\007\016 \026\002\013\001\006\013\001\013\007\216\001\025\203 )]TJ 0 -1 TD [(\232\001\201\025\024\220\n\002\025\207\220\002\215\002\202\220\220 \025\026\ \n\002\020\026)11.1(\025\203? \(\006\220\006)-10(\026)11(\016\024\013\026\220\017\016\006\n\220\203 \025\f\222\025\002 \220\022\024\ \016\026)11(\013\013\001\013\007\220\222\))]TJ 39.202 1 Td [(Is it safe to leav)12.1(e r)31(ectal w)11(ound opened af)-31(ter tr)21(ansanal )]TJ -0.067 -1 Td [(micr)20(osur)31.1(ger)-31(y? A s)10.1(y)9.9(stematic r)31(e)11(vie)11(w and meta-analy)10.1(sis.)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf -0.032 Tw 10 0 0 10 42.5197 408.2019 Tm (\024\023\036\030\026\006\017\017 \027\026)Tj /Span<>> BDC ( )Tj EMC (\023\030\016\n\024\005 \022\017\001\022\036, \026\022\035\033\004\026\033\ \013\031\033\f\016 \r)Tj /Span<>> BDC ( )Tj EMC (\023\024\035\027\024)Tj 0 Tw (-)Tj 0.128 Tw 0 -1.218 TD (\f\021\036\027\027\024\005 \030\036\036\022\006\017\017 \f\021\036\027\022\ \017 \023\030\016\n\024\005 \022\017\001\022\017 \r)Tj /Span<>> BDC ( )Tj EMC (\023\030\036\007\036\035\026\b )Tj 0.002 Tw 23.244 1.218 Td [(\007\024\030\024\r\t\b )0.5(\021\022\026\027\036\005. )0.6(\200)]TJ /Span<>> BDC ( )Tj EMC 8.303 0 Td [(\026\r\017\f\017\n\024\f\021\017 )0.5(\024\021 )0.5(\f\235\024\030\n\017\030\024\r\026\027\027\t\b )]TJ 0.056 Tw -8.303 -1.218 Td (\020\030\031\023\023 \030\026\027\026 \023\030\016\n\024\005 \022\017\001\ \022\017 \031\001\017\r\026\035\026\f\034 \017\035\017 \024\f\021\026\r\026\ \035\026\f\034 )Tj 0 Tw T* (\024\021\022\030\t\021\024\005.)Tj /T1_2 1 Tf 0 -2.436 TD (\255\020\032\020\034\255\020\034\021\032)Tj /T1_1 1 Tf 0.015 Tw 0 -1.218 TD [(\215\030\024\r\036\007\036\027\017\036 \n\036\021\026\026\027\026\035\017\ \026 )0.5(\024\f\031\013\036\f\021\r\035\016\035\024\f\034 \f)]TJ /Span<>> BDC ( )Tj EMC (\023\024\n\024\013\034\033 )Tj 0.295 Tw T* [(\023\030\024\020\030\026\n\n\t T)47(he R)13(ev)-15.9(iew Mana)-17(ger S)-16(of)-27.9(t)-32(w)-12(ar)-24(e \(R)13(evMan, )]TJ 0.608 Tw T* [(ver)-10(sion 5.4, Co)-16(chr)-32.9(ane Coll)-16(abor)-32.9(a)15(t)-32(ion\). \221\031\n\n\026\030\027\024\036 )]TJ 0.714 Tw T* (\027\026\004\036\027\017\036 \007\017\b\024\021\024\n\017\004\036\f\022\ \017\b \007\026\027\027\t\b \023\030\036\007\f\021\026\r\035\036\027\024\ )Tj 0.156 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\r\017\007\036 \024\021\027\024\001\036\027\017\016 \001\026\027\f\024\r\ \(\210\234\) \f)Tj /Span<>> BDC ( )Tj EMC (95% \007\024\r\036\030\017\021\036\035\034)Tj 0 Tw (-)Tj 0.237 Tw T* (\027\t\n \017\027\021\036\030\r\026\035\024\n \(\212\222\) \017)Tj /Span<>> BDC ( )Tj EMC (\f\021\026\027\007\026\030\021\017\026\006\017\036\005 \f\030\036\007\027\ \017\b. )Tj 0.126 Tw T* (\221\021\026\021\017\f\021\017\004\036\f\022\031\033 \020\036\021\036\030\ \024\020\036\027\027\024\f\021\034 \f\030\036\007\017 \017\f\f\035\036\007\ \024\r\026\027\017\005 )Tj 0.013 Tw T* (\024\006\036\027\017\r\026\035\017 \f)Tj /Span<>> BDC ( )Tj EMC (\023\024\n\024\013\034\033 \233)Tj 0 Tw 5.83 0 0 5.83 375.1748 265.3959 Tm (2)Tj 0.013 Tw 10 0 0 10 378.0898 262.0659 Tm ( \021\036\f\021\026. \221\021\026\021\017\f\021\017\004\036\f\022\017 \027\ \026\004\017)Tj 0 Tw (-)Tj -10.313 -1.218 Td (\n\024\005 \020\036\021\036\030\024\020\036\027\027\024\f\021\034\033 \f\ \004\017\021\026\035\017 I)Tj 5.83 0 0 5.83 403.9584 253.2179 Tm (2)Tj /Span<>> BDC 10 0 0 10 406.8734 249.8879 Tm ( )Tj EMC (>)Tj /Span<>> BDC ( )Tj EMC (50% \017)Tj /Span<>> BDC ( )Tj EMC /T1_3 1 Tf (\032)Tj /T1_1 1 Tf /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (0,05.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 275.0305 213.3539 Tm [(\033\034\020)21(\223)50(\r\241)46(\024)52(\026)45(\024\232)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0 Tc 0.131 Tw 10 0 0 10 274.9606 188.9979 Tm (\216\026\030\026\022\021\036\030\017\f\021\017\022\026 \024\021\024\002\030\ \026\027\027\t\b \017\f\f\035\036\007\024\r\026\027\017\005 \023\030\017\ \r\036\007\036)Tj 0 Tw (-)Tj 0.134 Tw T* (\027\026 \r)Tj /Span<>> BDC ( )Tj EMC (\021\026\002\035\017\006\036 2. \200\f\036\020\024 \r)Tj /Span<>> BDC ( )Tj EMC (\f\017\f\021\036\n\026\021\017\004\036\f\022\017\005 \024\002\024\030 \035\ \017)Tj 0 Tw (-)Tj 0.021 Tw T* [(\021\036\030\026\021\031\030\t )0.6(\002\t\035\024 )0.5(\r\022\035\033\004\036\027\024 )0.5(808 )0.5(\023\026\006\017\036\027\021\024\r, )0.6(\031)]TJ /Span<>> BDC ( )Tj EMC 17.858 0 Td (383)Tj /Span<>> BDC ( )Tj EMC 1.753 0 Td (\(47%\) )Tj 0.457 Tw -19.611 -1.218 Td (\030\026\027\026 \023\030\016\n\024\005 \022\017\001\022\017 \r\036\035\026\ \f\034 \024\021\022\030\t\021\t\n \f\023\024\f\024\002\024\n. )Tj 0.122 Tw T* (\200)Tj /Span<>> BDC ( )Tj EMC (\030\026\n\022\026\b \026\027\026\035\017\026 \r\036\035\026\f\034 \024\ \006\036\027\022\026 \023\036\030\r\017\004\027\t\b \007\026\027\027\t\b\ )Tj 0.424 Tw T* (\f\030\036\007\027\036\020\024 \030\026\n\036\030\026 \007\036\235\036\022\ \021\026 \017)Tj /Span<>> BDC ( )Tj EMC (\023\024\f\035\036\024\023\036\030\026\006\017\024\027\027\t\b )Tj 0.248 Tw T* (\024\f\035\024\032\027\036\027\017\005: \004\026\f\021\024\021\026 \022\030\ \024\r\024\021\036\004\036\027\017\005, \017\027\235\036\022\006\017\024\ \027\027\t\b )Tj 0.207 Tw T* [(\024\f\035\024\032\027\036\027\017\005, )0.6(\f\030\036\007\027\016\016 )0.5(\023\030\024\007\024\035\032\017\021\036\035\034\027\024\f\021\034 )0.6(\024\023\036\030\026\006\017\017 )]TJ -0.046 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\f\030\036\007\027\036\036 \r\030\036\n\016 \023\030\036\002\t\r\026\027\ \017\016 \r)Tj /Span<>> BDC ( )Tj EMC (\f\021\026\006\017\024\027\026\030\036 \023\024\f\035\036 \024\023\036)Tj 0 Tw (-)Tj T* (\030\026\006\017\017 \(\230\026\002\035.)Tj /Span<>> BDC ( )Tj EMC (2\).)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 9 0 0 9 42.5197 730.483 Tm (\020\004\206\f\t\204\004 1.)Tj 0 0 0 1 k /GS1 gs /T1_3 1 Tf ( PICO-\003\n\030\031\023\022 \n\024\005\n\032\026 \t\024\026\024\031\017\ \021\026)Tj /Span<>> BDC ( )Tj EMC (\026\021\026\023\025\016)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0 -1.2 TD [(T)48(able 1)47(.)]TJ 0 0 0 1 k /GS1 gs /T1_3 1 Tf [( PIC)21.1(O model for selecting ar)-39.8(ticles for analysis)]TJ ET 0 0 0 1 K 0.5 w /GS2 gs q 1 0 0 1 42.5197 715.181 cm 0 0 m 164.639 0 l S Q q 1 0 0 1 42.7697 703.9617 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 207.1582 715.181 cm 0 0 m 288.905 0 l S Q q 1 0 0 1 207.1582 703.9617 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 495.813 703.9617 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 42.5197 703.7117 cm 0 0 m 164.639 0 l S Q q 1 0 0 1 42.7697 692.5005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 207.1582 703.7117 cm 0 0 m 288.905 0 l S Q q 1 0 0 1 207.1582 692.5005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 495.813 692.5005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 692.2505 cm 0 0 m 164.639 0 l S Q q 1 0 0 1 42.7697 681.0392 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 207.1582 692.2505 cm 0 0 m 288.905 0 l S Q q 1 0 0 1 207.1582 681.0392 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 495.813 681.0392 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 680.7892 cm 0 0 m 164.639 0 l S Q q 1 0 0 1 42.7697 659.9779 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 207.1582 680.7892 cm 0 0 m 288.905 0 l S Q q 1 0 0 1 207.1582 659.9779 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 495.813 659.9779 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 42.5197 659.7279 cm 0 0 m 164.639 0 l S Q q 1 0 0 1 207.1582 659.7279 cm 0 0 m 288.905 0 l S Q BT /GS1 gs /T1_2 1 Tf 8 0 0 8 86.3167 706.5463 Tm (\026\013\206\002\006\220\004 \(Population\))Tj 15.503 0 Td (\200\004\204\t\r\b\003\013, \220\002\003\002\006\013\214 \013\212\002\f\ \b\r\b\004 \003\006\004\b\217\004\b\004\f\001\b\004\235 \234\b\240\002\217\ \220\002\212\t\201\r\217\220\004\235 \214\t\220\006\002\216\t\006\210\006\ \n\t\235)Tj /T1_1 1 Tf -20.592 -1.433 Td (\200\n\036\001\026\021\036\035\034\f\021\r\024 \(Intervention\))Tj 35.015 0 Td (\211\001\017\r\026\027\017\036 \030\026\027\t)Tj -35.015 -1.433 Td (\221\030\026\r\027\036\027\017\036 \(Comparison\))Tj 31.115 0 Td (\200\036\007\036\027\017\036 \030\026\027\t \024\021\022\030\t\021\t\n \f\ \023\024\f\024\002\024\n)Tj -31.115 -1.433 Td (\222\f\b\024\007\t \(Outcomes\))Tj 20.593 0 Td (\223\026\f\021\024\021\026 \023\024\f\035\036\024\023\036\030\026\006\017\ \024\027\027\t\b \024\f\035\024\032\027\036\027\017\005 \(\022\030\024\r\ \024\021\036\004\036\027\017\036, \023\030\017\f\024\036\007\017\027\036\ \027\017\036 \017\027\235\036\022\006\017\017\), )Tj 5.669 -1.2 Td (\007\035\017\021\036\035\034\027\024\f\021\034 \024\023\036\030\026\006\017\ \017 \017)Tj /Span<>> BDC ( )Tj EMC (\023\024\f\035\036\024\023\036\030\026\006\017\024\027\027\024\020\024 \022\ \024\005\022\024-\007\027\016)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 9 0 0 9 42.5197 643.0085 Tm (\020\004\206\f\t\204\004 2.)Tj 0 0 0 1 k /GS1 gs /T1_3 1 Tf ( \206\026\032\026\013\024\031\032\025\t\024\025\013\026 \027\013\023\007\ \006\031\021\021\020\004 \027)Tj /Span<>> BDC ( )Tj EMC (\003\031\024\026\026\021\026\023\025\016 \025\t\t\023\031\030\n\027\026\021\ \025\017)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf T* [(T)48(able 2)16(.)]TJ 0 0 0 1 k /GS1 gs /T1_3 1 Tf [( Character)-36.9(istics of the studies included in the meta-analysis)]TJ ET /GS2 gs q 1 0 0 1 42.5197 627.7066 cm 0 0 m 65.447 0 l S Q q 1 0 0 1 42.7697 575.2124 cm 0 0 m 0 52.244 l S Q q 1 0 0 1 107.9665 627.7066 cm 0 0 m 19.843 0 l S Q q 1 0 0 1 107.9665 575.2124 cm 0 0 m 0 52.244 l S Q q 1 0 0 1 127.8091 627.7066 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 127.8091 575.2124 cm 0 0 m 0 52.244 l S Q q 1 0 0 1 173.1634 627.7066 cm 0 0 m 73.701 0 l S Q q 1 0 0 1 173.1634 575.2124 cm 0 0 m 0 52.244 l S Q q 1 0 0 1 246.8642 627.7066 cm 0 0 m 31.181 0 l S Q q 1 0 0 1 246.8642 575.2124 cm 0 0 m 0 52.244 l S Q q 1 0 0 1 278.0453 627.7066 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 278.0453 575.2124 cm 0 0 m 0 52.244 l S Q q 1 0 0 1 323.3996 627.7066 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 323.3996 575.2124 cm 0 0 m 0 52.244 l S Q q 1 0 0 1 371.5886 627.7066 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 371.5886 575.2124 cm 0 0 m 0 52.244 l S Q q 1 0 0 1 431.1161 627.7066 cm 0 0 m 65.447 0 l S Q q 1 0 0 1 431.1161 575.2124 cm 0 0 m 0 52.244 l S Q q 1 0 0 1 496.313 575.2124 cm 0 0 m 0 52.244 l S Q q 1 0 0 1 42.5197 574.9624 cm 0 0 m 65.447 0 l S Q q 1 0 0 1 42.7697 556.0751 cm 0 0 m 0 18.637 l S Q q 1 0 0 1 107.9665 574.9624 cm 0 0 m 19.843 0 l S Q q 1 0 0 1 107.9665 556.0751 cm 0 0 m 0 18.637 l S Q q 1 0 0 1 127.8091 574.9624 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 127.8091 556.0751 cm 0 0 m 0 18.637 l S Q q 1 0 0 1 173.1634 574.9624 cm 0 0 m 73.701 0 l S Q q 1 0 0 1 173.1634 556.0751 cm 0 0 m 0 18.637 l S Q q 1 0 0 1 246.8642 574.9624 cm 0 0 m 31.181 0 l S Q q 1 0 0 1 246.8642 556.0751 cm 0 0 m 0 18.637 l S Q q 1 0 0 1 278.0453 574.9624 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 278.0453 556.0751 cm 0 0 m 0 18.637 l S Q q 1 0 0 1 323.3996 574.9624 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 323.3996 556.0751 cm 0 0 m 0 18.637 l S Q q 1 0 0 1 371.5886 574.9624 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 371.5886 556.0751 cm 0 0 m 0 18.637 l S Q q 1 0 0 1 431.1161 574.9624 cm 0 0 m 65.447 0 l S Q q 1 0 0 1 431.1161 556.0751 cm 0 0 m 0 18.637 l S Q q 1 0 0 1 496.313 556.0751 cm 0 0 m 0 18.637 l S Q q 1 0 0 1 42.5197 555.8251 cm 0 0 m 65.447 0 l S Q q 1 0 0 1 42.7697 528.5378 cm 0 0 m 0 27.037 l S Q q 1 0 0 1 107.9665 555.8251 cm 0 0 m 19.843 0 l S Q q 1 0 0 1 107.9665 528.5378 cm 0 0 m 0 27.037 l S Q q 1 0 0 1 127.8091 555.8251 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 127.8091 528.5378 cm 0 0 m 0 27.037 l S Q q 1 0 0 1 173.1634 555.8251 cm 0 0 m 73.701 0 l S Q q 1 0 0 1 173.1634 528.5378 cm 0 0 m 0 27.037 l S Q q 1 0 0 1 246.8642 555.8251 cm 0 0 m 31.181 0 l S Q q 1 0 0 1 246.8642 528.5378 cm 0 0 m 0 27.037 l S Q q 1 0 0 1 278.0453 555.8251 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 278.0453 528.5378 cm 0 0 m 0 27.037 l S Q q 1 0 0 1 323.3996 555.8251 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 323.3996 528.5378 cm 0 0 m 0 27.037 l S Q q 1 0 0 1 371.5886 555.8251 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 371.5886 528.5378 cm 0 0 m 0 27.037 l S Q q 1 0 0 1 431.1161 555.8251 cm 0 0 m 65.447 0 l S Q q 1 0 0 1 431.1161 528.5378 cm 0 0 m 0 27.037 l S Q q 1 0 0 1 496.313 528.5378 cm 0 0 m 0 27.037 l S Q q 1 0 0 1 42.5197 528.2878 cm 0 0 m 65.447 0 l S Q q 1 0 0 1 42.7697 501.0005 cm 0 0 m 0 27.037 l S Q q 1 0 0 1 107.9665 528.2878 cm 0 0 m 19.843 0 l S Q q 1 0 0 1 107.9665 501.0005 cm 0 0 m 0 27.037 l S Q q 1 0 0 1 127.8091 528.2878 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 127.8091 501.0005 cm 0 0 m 0 27.037 l S Q q 1 0 0 1 173.1634 528.2878 cm 0 0 m 73.701 0 l S Q q 1 0 0 1 173.1634 501.0005 cm 0 0 m 0 27.037 l S Q q 1 0 0 1 246.8642 528.2878 cm 0 0 m 31.181 0 l S Q q 1 0 0 1 246.8642 501.0005 cm 0 0 m 0 27.037 l S Q q 1 0 0 1 278.0453 528.2878 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 278.0453 501.0005 cm 0 0 m 0 27.037 l S Q q 1 0 0 1 323.3996 528.2878 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 323.3996 501.0005 cm 0 0 m 0 27.037 l S Q q 1 0 0 1 371.5886 528.2878 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 371.5886 501.0005 cm 0 0 m 0 27.037 l S Q q 1 0 0 1 431.1161 528.2878 cm 0 0 m 65.447 0 l S Q q 1 0 0 1 431.1161 501.0005 cm 0 0 m 0 27.037 l S Q q 1 0 0 1 496.313 501.0005 cm 0 0 m 0 27.037 l S Q q 1 0 0 1 42.5197 500.7505 cm 0 0 m 65.447 0 l S Q q 1 0 0 1 42.7697 481.8632 cm 0 0 m 0 18.637 l S Q q 1 0 0 1 107.9665 500.7505 cm 0 0 m 19.843 0 l S Q q 1 0 0 1 107.9665 481.8632 cm 0 0 m 0 18.637 l S Q q 1 0 0 1 127.8091 500.7505 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 127.8091 481.8632 cm 0 0 m 0 18.637 l S Q q 1 0 0 1 173.1634 500.7505 cm 0 0 m 73.701 0 l S Q q 1 0 0 1 173.1634 481.8632 cm 0 0 m 0 18.637 l S Q q 1 0 0 1 246.8642 500.7505 cm 0 0 m 31.181 0 l S Q q 1 0 0 1 246.8642 481.8632 cm 0 0 m 0 18.637 l S Q q 1 0 0 1 278.0453 500.7505 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 278.0453 481.8632 cm 0 0 m 0 18.637 l S Q q 1 0 0 1 323.3996 500.7505 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 323.3996 481.8632 cm 0 0 m 0 18.637 l S Q q 1 0 0 1 371.5886 500.7505 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 371.5886 481.8632 cm 0 0 m 0 18.637 l S Q q 1 0 0 1 431.1161 500.7505 cm 0 0 m 65.447 0 l S Q q 1 0 0 1 431.1161 481.8632 cm 0 0 m 0 18.637 l S Q q 1 0 0 1 496.313 481.8632 cm 0 0 m 0 18.637 l S Q q 1 0 0 1 42.5197 481.6132 cm 0 0 m 65.447 0 l S Q q 1 0 0 1 42.7697 462.726 cm 0 0 m 0 18.637 l S Q q 1 0 0 1 107.9665 481.6132 cm 0 0 m 19.843 0 l S Q q 1 0 0 1 107.9665 462.726 cm 0 0 m 0 18.637 l S Q q 1 0 0 1 127.8091 481.6132 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 127.8091 462.726 cm 0 0 m 0 18.637 l S Q q 1 0 0 1 173.1634 481.6132 cm 0 0 m 73.701 0 l S Q q 1 0 0 1 173.1634 462.726 cm 0 0 m 0 18.637 l S Q q 1 0 0 1 246.8642 481.6132 cm 0 0 m 31.181 0 l S Q q 1 0 0 1 246.8642 462.726 cm 0 0 m 0 18.637 l S Q q 1 0 0 1 278.0453 481.6132 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 278.0453 462.726 cm 0 0 m 0 18.637 l S Q q 1 0 0 1 323.3996 481.6132 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 323.3996 462.726 cm 0 0 m 0 18.637 l S Q q 1 0 0 1 371.5886 481.6132 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 371.5886 462.726 cm 0 0 m 0 18.637 l S Q q 1 0 0 1 431.1161 481.6132 cm 0 0 m 65.447 0 l S Q q 1 0 0 1 431.1161 462.726 cm 0 0 m 0 18.637 l S Q q 1 0 0 1 496.313 462.726 cm 0 0 m 0 18.637 l S Q q 1 0 0 1 42.5197 462.476 cm 0 0 m 65.447 0 l S Q q 1 0 0 1 42.7697 443.5887 cm 0 0 m 0 18.637 l S Q q 1 0 0 1 107.9665 462.476 cm 0 0 m 19.843 0 l S Q q 1 0 0 1 107.9665 443.5887 cm 0 0 m 0 18.637 l S Q q 1 0 0 1 127.8091 462.476 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 127.8091 443.5887 cm 0 0 m 0 18.637 l S Q q 1 0 0 1 173.1634 462.476 cm 0 0 m 73.701 0 l S Q q 1 0 0 1 173.1634 443.5887 cm 0 0 m 0 18.637 l S Q q 1 0 0 1 246.8642 462.476 cm 0 0 m 31.181 0 l S Q q 1 0 0 1 246.8642 443.5887 cm 0 0 m 0 18.637 l S Q q 1 0 0 1 278.0453 462.476 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 278.0453 443.5887 cm 0 0 m 0 18.637 l S Q q 1 0 0 1 323.3996 462.476 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 323.3996 443.5887 cm 0 0 m 0 18.637 l S Q q 1 0 0 1 371.5886 462.476 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 371.5886 443.5887 cm 0 0 m 0 18.637 l S Q q 1 0 0 1 431.1161 462.476 cm 0 0 m 65.447 0 l S Q q 1 0 0 1 431.1161 443.5887 cm 0 0 m 0 18.637 l S Q q 1 0 0 1 496.313 443.5887 cm 0 0 m 0 18.637 l S Q q 1 0 0 1 42.5197 443.3387 cm 0 0 m 65.447 0 l S Q q 1 0 0 1 107.9665 443.3387 cm 0 0 m 19.843 0 l S Q q 1 0 0 1 127.8091 443.3387 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 173.1634 443.3387 cm 0 0 m 73.701 0 l S Q q 1 0 0 1 246.8642 443.3387 cm 0 0 m 31.181 0 l S Q q 1 0 0 1 278.0453 443.3387 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 323.3996 443.3387 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 371.5886 443.3387 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 431.1161 443.3387 cm 0 0 m 65.447 0 l S Q BT /GS1 gs /T1_2 1 Tf 7 0 0 7 66.4047 598.7971 Tm (\032\003\002\006)Tj 6.591 0 Td (\027\002\240)Tj 3.041 0.6 Td (\031\t\213\004\005\b \t\217)Tj (-)Tj -0.184 -1.2 Td (\217\f\r\240\002\004\b\t\235)Tj 6.328 1.2 Td (\022\004\213\214\r\006 \006\004\b\013 \(\210\230\t\004)Tj (-)Tj 0.321 -1.2 Td (\b\t\r/\002\003\220\006\013\003\004\235 \006\004\b\004\))Tj 10.396 2.4 Td (N \210\230\t)Tj (-)Tj -0.005 -1.2 Td (\004\b\t\r/)Tj -0.011 -1.2 Td (\002\003\220\006\013)Tj (-)Tj -0.018 Tw -0.292 -1.2 Td (\003\004\235 \006\004\b\004)Tj 0 Tw 4.915 4.2 Td (N \220\006\002\002\003\r)Tj (-)Tj -0.357 -1.2 Td (\201\r\b\t\005 \(\210\230\t)Tj (-)Tj 0.678 -1.2 Td (\003\004\235 \006\004\b\004/ )Tj 0.012 -1.2 Td (\002\003\220\006\013\003\004\235 )Tj 0.801 -1.2 Td (\006\004\b\004\))Tj 5.889 5.4 Td (N \t\b\226\r\220)Tj (-)Tj 0.097 -1.2 Td (\204\t\002\b\b\013\216 )Tj -0.772 -1.2 Td (\002\217\f\002\202\b\r\b\t\005 )Tj 0.899 -1.2 Td (\(\210\230\t\003\004\235 )Tj -1.077 -1.2 Td (\006\004\b\004/ \002\003\220\006\013)Tj (-)Tj 0.834 -1.2 Td (\003\004\235 \006\004\b\004\))Tj 6.84 5.4 Td (\255\006\r\240\b\235\235 \212\006\002)Tj (-)Tj -0.689 -1.2 Td (\240\002\f\202\t\003\r\f\001\b\002\217\003\001 )Tj 0.072 -1.2 Td (\002\212\r\006\004\204\t\t \(\214\t\b\) )Tj 0.357 -1.2 Td (\(\210\230\t\003\004\235 \006\004\b\004/ )Tj -0.231 -1.2 Td (\002\003\220\006\013\003\004\235 \006\004\b\004\))Tj 8.886 4.8 Td (\255\006\r\240\b\t\005 \212\002\217\f\r)Tj (-)Tj 0.153 -1.2 Td (\002\212\r\006\004\204\t\002\b\b\013\005 )Tj -0.671 -1.2 Td (\220\002\005\220\002-\240\r\b\001 \(\210\230\t)Tj (-)Tj -0.272 -1.2 Td (\003\004\235 \006\004\b\004/ \002\003\220\006\013\003\004\235 )Tj 2.972 -1.2 Td (\006\004\b\004\))Tj /T1_1 1 Tf -58.49 -2.134 Td (Ramirez 2002 [5])Tj 9.326 0 Td (2002)Tj 4.663 0 Td (\217\025\222)Tj 4.081 0 0 4.081 155.4019 569.3908 Tm (1)Tj 7 0 0 7 177.9541 567.0598 Tm (4,0)Tj /Span<>> BDC ( )Tj EMC (\(3\2266\) \f\n/ 4,3)Tj /Span<>> BDC ( )Tj EMC (\(2,5\226)Tj 1.711 -1.2 Td (10\) \f\n )Tj /T1_3 1 Tf (p)Tj /T1_1 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (\027/\007)Tj 9.139 1.2 Td (21/19)Tj 5.967 0 Td (1/1)Tj 6.682 0 Td (0/0)Tj 5.337 0 Td (93,8)Tj /Span<>> BDC ( )Tj EMC (\(40\226180\)/)Tj 0.221 -1.2 Td (77,8)Tj /Span<>> BDC ( )Tj EMC (\(20\226180\))Tj 7.83 1.2 Td (3,8)Tj /Span<>> BDC ( )Tj EMC (\(2\2266\)/3,9)Tj /Span<>> BDC ( )Tj EMC (\(2\2267\))Tj -55.795 -2.734 Td (Hahnloser 2009\226)Tj 0 -1.2 TD (2012 [8])Tj 9.326 1.2 Td (2015)Tj 4.663 0 Td (\217\025\222)Tj 4.081 0 0 4.081 155.4019 550.2535 Tm (1)Tj 7 0 0 7 189.0981 547.9225 Tm (\215\035\024\013\026\007\034 \030\026\027\t )Tj -0.3 -1.2 Td (1218)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (914 \n\n)Tj 4.081 0 0 4.081 227.8865 541.8535 Tm (2)Tj 7 0 0 7 229.927 539.5225 Tm (/ )Tj -7.543 -1.2 Td (1404)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (1078 \n\n)Tj 4.081 0 0 4.081 221.5102 533.4535 Tm (2 )Tj /T1_3 1 Tf 7 0 0 7 224.5015 531.1225 Tm (p)Tj /T1_1 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,4)Tj 4.2 2.4 Td (40/35)Tj 5.967 0 Td (1/4)Tj 6.682 0 Td (1/0)Tj 6.341 0 Td (90)Tj /Span<>> BDC ( )Tj EMC (\(\261)Tj /Span<>> BDC ( )Tj EMC (51\)/)Tj 0.222 -1.2 Td (62)Tj /Span<>> BDC ( )Tj EMC (\(\261)Tj /Span<>> BDC ( )Tj EMC (16\))Tj 8.502 1.2 Td (3,4)Tj /Span<>> BDC ( )Tj EMC (\(\261)Tj /Span<>> BDC ( )Tj EMC (1,9\)/)Tj 0.222 -1.2 Td (3,4)Tj /Span<>> BDC ( )Tj EMC (\(\261)Tj /Span<>> BDC ( )Tj EMC (3,5\))Tj -57.692 -2.734 Td (Noura 2004\2262015 )Tj 0 -1.2 TD ([6])Tj 9.326 1.2 Td (2016)Tj 3.368 0 Td (\217\036\021\030\024\f\023\036\022)Tj (-)Tj 0.864 -1.2 Td (\021\017\r\027\024\036)Tj 5.469 1.2 Td (2,2)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (0,8 \(1,0\2263,0\) \f\n/)Tj 0.222 -1.2 Td (2,6)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (1,2 \(1,5\2263,0\) \f\n )Tj /T1_3 1 Tf 2.618 -1.2 Td (p)Tj /T1_1 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0.37)Tj 7.89 2.4 Td (21/22)Tj 5.967 0 Td (5/0)Tj 6.682 0 Td (4/2)Tj 5.656 0 Td (72,5)Tj /Span<>> BDC ( )Tj EMC (\(\261)Tj /Span<>> BDC ( )Tj EMC (51,9\)/)Tj 0.222 -1.2 Td (72,6)Tj /Span<>> BDC ( )Tj EMC (\(\261)Tj /Span<>> BDC ( )Tj EMC (34,0\))Tj 8.687 1.2 Td (12,6)Tj /Span<>> BDC ( )Tj EMC (\(\261)Tj /Span<>> BDC ( )Tj EMC (11,5\)/)Tj 0.721 -1.2 Td (9,9)Tj /Span<>> BDC ( )Tj EMC (\(\261)Tj /Span<>> BDC ( )Tj EMC (4,9\))Tj -57.692 -2.734 Td (Lee 1997\2262016 [16])Tj 9.326 0 Td (2018)Tj 3.368 0 Td (\217\036\021\030\024\f\023\036\022)Tj (-)Tj 0.864 -1.2 Td (\021\017\r\027\024\036)Tj 5.627 1.2 Td (3,4)Tj /Span<>> BDC ( )Tj EMC (\(1,6\) \f\n/ 2,8)Tj /Span<>> BDC ( )Tj EMC (\(2,0\) )Tj 2.116 -1.2 Td (\f\n )Tj /T1_3 1 Tf (p)Tj /T1_1 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,04)Tj 7.955 1.2 Td (215/215)Tj 6.217 0 Td (3/10)Tj 6.932 0 Td (5/3)Tj 6.341 0 Td (88)Tj /Span<>> BDC ( )Tj EMC (\(\261)Tj /Span<>> BDC ( )Tj EMC (50\)/)Tj 0.221 -1.2 Td (87)Tj /Span<>> BDC ( )Tj EMC (\(\261)Tj /Span<>> BDC ( )Tj EMC (46\))Tj 6.557 1.2 Td (1,4)Tj /Span<>> BDC ( )Tj EMC (\(\261)Tj /Span<>> BDC ( )Tj EMC (1,9\)/2)Tj /Span<>> BDC ( )Tj EMC (\(\261)Tj /Span<>> BDC ( )Tj EMC (3,15\))Tj -55.525 -2.734 Td (Brown 2012\2262013 )Tj T* ([9])Tj 9.326 1.2 Td (2019)Tj 4.663 0 Td (\217\025\222)Tj 4.081 0 0 4.081 155.4021 476.0417 Tm (1)Tj 7 0 0 7 176.4529 473.7107 Tm (3,9)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (0,78 \f\n/ 3,3)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (0,56 )Tj 2.609 -1.2 Td (\f\n )Tj /T1_3 1 Tf (p)Tj /T1_1 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,19)Tj 8.455 1.2 Td (28/22)Tj 5.967 0 Td (2/5)Tj 6.682 0 Td (1/0)Tj 6.341 0 Td (54)Tj /Span<>> BDC ( )Tj EMC (\(\261)Tj /Span<>> BDC ( )Tj EMC (11\)/)Tj 0.221 -1.2 Td (49)Tj /Span<>> BDC ( )Tj EMC (\(\261)Tj /Span<>> BDC ( )Tj EMC (12\))Tj 8.002 1.2 Td (0,39)Tj /Span<>> BDC ( )Tj EMC (\(\261)Tj /Span<>> BDC ( )Tj EMC (0,21\)/)Tj 0.588 -1.2 Td (0,32)Tj /Span<>> BDC ( )Tj EMC (\(0,24\))Tj -57.559 -1.534 Td (Altaf 2012\2262019 [7])Tj 9.326 0 Td (2021)Tj 3.368 0 Td (\217\036\021\030\024\f\023\036\022)Tj (-)Tj 0.864 -1.2 Td (\021\017\r\027\024\036)Tj 5.441 1.2 Td (3,5)Tj /Span<>> BDC ( )Tj EMC (\(1\22610\) \f\n/ 3,0)Tj /Span<>> BDC ( )Tj EMC (\(2\226)Tj 1.408 -1.2 Td (6,5\) \f\n )Tj /T1_3 1 Tf (p)Tj /T1_1 1 Tf /Span<>> BDC ( )Tj EMC (>)Tj /Span<>> BDC ( )Tj EMC (0,05)Tj 9.099 1.2 Td (100/70)Tj 6.217 0 Td (2/3)Tj 6.682 0 Td (3/2)Tj 6.05 0 Td (\203\036\021 \007\026\027\027\t\b)Tj 7.64 0 Td (3)Tj /Span<>> BDC ( )Tj EMC (\(\261)Tj /Span<>> BDC ( )Tj EMC (\203\212\)/4)Tj /Span<>> BDC ( )Tj EMC (\(\261)Tj /Span<>> BDC ( )Tj EMC (\203\212\))Tj /T1_3 1 Tf -56.536 -3.246 Td (\032\025\003\031\006\026\021\025\031: \212\222\215)Tj /Span<>> BDC ( )Tj EMC (\227 \032\026\021\030\n\003\025\016\025\032\n\027\026\021\021\n\031 \013\ \023\025\021\025\006\031\t\013\n\031 \025\t\t\023\031\030\n\027\026\021\025\ \031)Tj ET q /GS0 gs 221.1023475 0 0 255.4320468 42.5196833 122.6297331 cm /Im0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.049 Tw 9 0 0 9 42.5197 111.7959 Tm (\022\t\217\210\b\002\220 1.)Tj 0 0 0 1 k /GS1 gs /T1_3 1 Tf ( \213\023\n\013-\t\004\031\003\026 \033\032\n\203\031\t\t\026 \n\024\005\ \n\032\026 \025\t\t\023\031\030\n\027\026\021\025\017 \030\023\002 )Tj 0 Tw T* (\003\031\024\026\026\021\026\023\025\016\026)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.014 Tw T* [(F)-16(igure )0.6(1)47(.)]TJ 0 0 0 1 k /GS1 gs /T1_3 1 Tf [( )0.5(Flow)11(char)-39.9(t )0.5(of )0.5(the )0.6(research )0.6(selection )0.6(p)46(rocess )0.5(for )0.6(meta-)]TJ 0 Tw T* (analysis)Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\214)10(\211\036\033 \035\030\032\t\033)30(\b)42(\032)-21(\240\033\233)]TJ 57.136 0 Td (REVIEW)Tj /T1_5 1 Tf 25 0 0 25 505.5021 56.0378 Tm (183)Tj ET endstream endobj 109 0 obj <>stream Adobed     '$''''$25552;;;;;;;;;;   ####''',,,   ####''',,,   ####''',,,""   s4!1aq$2ABQ "#%&'()*356789:CDEFGHIJRSTUVWXYZbcdefghijrtuvwxyz w!1"2AQraq$Rb#BD U%&'()*3456789:CEFGHIJSTVWXYZcdefghijstuvwxyz?@:S':#bD;j.kT $0DEN;>_>v}ioK?n{oDDU'gӹϽkD5UȮb+U52S߰'_͠S**eCj苵/L\l,kef2HhNƺ:{uH__ϵTO_ϵT@E"|k~>׷Q׷QT^D^D]R.ƺ:{ƺ:{uH__ϵTO_ϵT@E"|k~>׷Q׷QT^D^D]R.ƺ:{ƺ:{uH__ϵTO_ϵT@E".a}. [5ｶٲK&AgЇb]""" """"" """"" """"" """"" """"" """"" """H봹 $YS Vr+{Iz1mb+6Z%Jr=jҵW#1LI.--,_6klY<ڎҮE\lrܰz:RX>Ͳ,ţfZZKձkF2pk]B]y 6[4Z.f&Z Mi  ;= k6.-QhMvT\2r)ٴ[vZu=ֺy6˧bY=W.|MB.ؿu)t^VeϪv7 p$@C%BjՍWvuB'1XPƻSfC5ʛ6r;XsuGpDD@Wk"zWTӛk"zWTӛ[ze{Zi!Ņ1;Xnͷ,l99ָa "}h{E|k\0\zUukVv̳6guvbvƍ/]9s3{ AwAm{,Z遇LurDr79KK86Lk,VYh I/.Sgh 'xh'qZ\6$v4΋o/a|]2۫.6wb,ziK.2I5+;͓zZڛG^-dbh KtCm 5i_Z4_#z Ž{M[Ztiuen׵:Fn(ҕ=;W+kckl{^u6:kF-(:&gerq84chuYL/~o:l_`9{鉭p-nU-nvWQ{km,xfԋ1lI 8 ʶק. id/.v$E5IlbH_=|Z\6[X6cn&0`HY`vXM; GGtZyv"xpmikuEi"$> dB|z?wZL:fxȱiuYb\C:)ʼn꒵xIex6bɖ㭳l hka/Ɲ {3s; [[խ^.ϼ^֖ݭk l y#a?s soF-p\fm-;Ecగ̠"'S 2o} ,:]δ_͛ /%v}]ή S<&u:6eh /6֍GV0&Xb52 /6Eٝ#R.!ז97vhT-tċFEuk6l8]쩳`)yWTwDDv'~N9v'~N9smiih4 IEakj^,쭘u`\ hm! Җ8:ۅcѸ醉m\`\GDuoSi,%n!Q9𛣈xk/NoC`gՒ-O,@p$H\.ܮ՞QicvqVZ1ָCHe@E讐g[xoIx$tA k}!c&xÂqؽ֒97y_AҞ\:D۹X8[Y0_Mclz["Xb+DŽ[,mZ6uLZCF]"&WX ٵuֻT Pm녻u"H"Y2-)u%W/z>oN[XYXXZm+KSf[g$̓EGq{,f}`p5̼9$#DRP|[`.aO/6dHplIiw8xu$=sDe+t}zwQqf<2uo[.an6U8IVtɀEuN_oȺys4Ҵ TCtEmC`;M'%twL.7`lB[ VHi8,.[ :*ٸb!m؃8f8(g/J?ch1r$az6 ٻ %}׭{zYutf:j_uako]ꖘ]%{|wb^MǨho9K[LOa:8Hqh]+z'^ܯ$ZX6%8j"HmaY>ϭ`{1 KN($:Cloumն}[lv7Ki%R;{+{ݩ v YYb (k"SUi^?ȮZ~HR*&H2*&u,/ZW""74#CX+lXeV2\XdTUͬl@Eπ?jǧ zlzZgcx}V֝} /c5"I`]J""" """"" """"" """"" """"" """"" """"" """H/*&o*&]5)zW""'Mk.]lkem9feTGeګx쬷ZZ$di^\bʛfҗEhgf}df` ;N{ ]Bzy^klۥ0 :3ꗐƻSfS5ʛ6rsy]rDD@DDDDD@DDDDD@E_E.av?#!ܿpjHr/'ޒ +]υ'ޒ +@DDDDD@DDDDD@DDDDD@DDDDD@DDDDD@DDDDD@DDDDD@DDDDD@DDDDD@HRu]TiZ|)jUVZ"dG&|ۂkwn%exun`zs^`j#JҦU\:U^ 얜'x}xiBwʺ/F<%/n߃Es̸I@ظֵtU˓mUPrwZsPAޏ[]*Fҷ.:d*1 ښaHW'9ΌD 3d`ܸ.tTEK6d9 &I;@r"""" """"" """"" "N?ҍ__8\J5$FC¿I}{.¿I}{ """"" """"" """"" """"" """"" """"" """"" """"" """"" @"""" """"" """"" """"" """*/s (r kK{/v2洐!́ 2zK.ܮwX[7Fټ3ߦZCjiXIeXHDӹ6Uϑ7 -ET[CdL6} ËZ ĺ) ^`e-k_Pl3{ y;Ϝ"/]}y}Cg.Ebmf:r.qN%]A`LDT#"+r9TEM8]쩳`)HUxDD@Qw Qznm.urhGnȯltwV.hc6f 09/^`밴p{YI^@qH"? /xGnlNв.#7l_,H/*/*ݵ,/:W""X]][bǵ^r\&i|Y fiawu}Ymmf汴oT,35E!wm.,X2MLdTʚOu+?Fvxn [C bDn5ʛ6rQTٰCǼ۪;"">Zx˯mVu/llĹ- \>YUD|_SNn@EF|ګOπ{UokD]gK=4 gV@EF|ګOπ{UokD]gK=4 gV@EF|ګOπ{UokD]gK=4 gV@EF|ګOπ{UokD]gK=4 gV@EF|ګOπ{UokD]召Ysu-xm !tk])*/w]R"" """"" """"" """"" """"" """"" """"" """Ho*&ro*&u,/ZW""?5l9qm[&L쪎Ȩa|Z$ YvJNG"Mi:;pnr.Va]>Yki}mܛVؖYs %s teGYkt@ek6ĀZ[dISAqWٮG*iUs|a۴[vOAC#+\뫭;vKwT܇]gN-6bĵumCt[AiCu˰鶆t塖V`і,iiinZV͠DJ7qblr -{mpCjìLv.^ne.^hמuaIl~-lZm| llAH gxFpvT.Oh-,-|JdY_ޭv.ӴFtu׋Ko84!H+:BezmGml84 K2]BHB;7vݞkqmKƃ6u"~8 >WM}2a|`{ 'fIJG]ϰlm-X>ΰ:K4ƃA-`0"s@EUn}wˍډhhLƹWi{\q^--oͣa [P]COU{k"SUi^DD@DDDDD@DDDDD@DDDDD@DDDDD@DDDDD@DDDDD@DDDHR*&HR*&u,/ZW""4^DcɵT[ TnMijTʪݠˢ-[&(>fr#4z˕U5 )S4_K"z=5oq`eu6v"ı=^(ktGVY[&܍ѥͲM؂[8LJɓB&G7%++:UTj;W`u4&Z[76"WLι]ݞvUu=5qZi;bt[V ]z7 f[ǯlձ$3FؠW]쩳`)eM9H{ʽ"" _菑=+*wuK菑=+*wuH])*/w]RzWJ}?KTZ^m,+K{F1@IWdz٤ޮ1.k o~?]+_zzµkǠ"v~? oEµkǧ+_z.k o~?]+_zzµkǠ"v~? oEµkǧ+_z.k oo%ڛ++KB+兣Y45$A4܀DDH2*&2*&]u)ZW""#ϳ]k"wJˑvٓq+$]Ek[v9,ޮ[5r*3͸8).xmhoNNaq-l6 #H9w^oE1fnֶZf27Y$b+k3fijk,[.f]2rU2d)=xR`ԴdFq1s+uM?j;W`~D#k>7#h wus0fެ4bŋ&s]:`fh(7=Tk6l8]쩳`!׻X7TwDDvl:Fcm-5`es:li5;|Hn]sN@ECutt뿵?D]{7]'O|Hn]sN@ECutt뿵?D]{7]'O|Hn]sN@ECutt뿵?[|+!u:{Cuu9a-{K\31\Pvw=!u:k k=\vw=!u:]:6~ӣ]\^kgj '-a'n]JIym_A;av*%}Pdw;F\/7wo]pvx-au"[Q&@.ag՝v-FIp*j@ޞ:OnYlާ/W5؛Fh{b[$HPGz)k?%7gH[.vSxt饲.H3/*&/*&]5)zW""%2GY87bil͵cuLPTDA r~/n6b 6vC8# hT\P-m2dۑ^WUW]{_+?@~z}ix}h遰D^EeM98{*l!u=vMwDDo__Y0_k=Fp7o__Y0_k=Fp<:H_#Wͯ#|o]^~Z w ")yk-)yk-[x|x|,Qm◟I◟HE^~Z w'^~Z w ")yk-)yk-[x|x|,Qm◟JˏAHf_a`R9 86E\*A;av*%}U}~tڟqъ,[tnai#ɳ!f[WmZ˻-Xa=;H/X=+~%on ̛6'Fȝ˘s ލk tP@E.ǥukZ-/oZ\ZlX]sNINsz7;a`IpI٥NBt-,]s˰ NSf_zvwskzvZ7V[q `-p`kd'bŽ;]w{(R7H6XI.8#Z;zUf+Of]U:ͳnlme֋0Èz0=j.«m͞'u6uB׳،$ lͻZY^KvYIssY%"`N{:c[!piqz̆K#3 .,-R.ɏu.$iZa`skMޙoJY]pmjA-`c&HIá:Nv;kFce,l7,/]{u~3`q7x@E2.ɽuq[3:MGS:tJ0Z\%G@ZWe\ u݂& F*;twUKo"á}i|.6XpC"юD£b«Kٶw15`:hmKmOV_-s8 CT@Ee 4>Ć@fKg.K+݅-o7 <룃0F" DVOѽ|V>,,l},ݎ֌p&`Rp=ymdXq[Y0- N.gj+{u,-8K@v5ɞ\l-1X]ŗZ^KV?n-q`(\w u'Bbp:%m˷[o`ե^lwY۱-V -]x A$--%Z/7E6f1mS/ `P6xNmUcGY n7vY0X42YN$HEYx/Vvuض۪vf/\A?`a6 i؂w$2*B-nX6nͳlꮶѭsř]+[͍k7~Z={fbC`FIry{EfodLm <agndlٲlj.-J.evg{s7<رY%d[+aW 흋!䷪{ ց /:BڋFlMf@.,$bȐoiwZX\A"oV +hյN`/.E;7wރmŐkIsNgb .쬭,, XZv }c7Gt-igfuֱP"XxQev;+bؽ"Ѷsasn,CzemhK[mawLZ-5 -" *Ng|^o6Msx yìqqLv*,Ke.נ~JobΑ4@E""Nl%5ٹrj*frk%A6@p$y".Xij7+NS}}>uè̈bsyac-sQ^lmhD=Xك!Gb"" """" """"" """"" ">?F -g>?F -gx?_)Dj~|wa'n]JIym_A;av*%}Pdt53xqx}b ͮ::^iޒ]1>ݯ}-6֗BZy}le*Ch[Kْup\!]m Kkmr}9}qZ(.lI]* "+ d7ukF0[ZusƊ[ęES|5xek+kգũ-7< kCh鮞Ώ{ih@˅pZ\LUEecueٌ߭/,/s eX]2 "+ &؋f2ɖ,7jHh H?,YgwqXƹaC$@E]펼|.f#b Fl+OM߭.ʹ6X46a^a LUtjZ˧t]R.=>˧ttTt=#l='@E"}#l='O|Hk.uH_|Hk.=>˧t]R.=>˧ttTt=#l='@E.נ~JobΑ4O|Hk.սWc͑zⴻZ5q.q|" HS DIS Vr+{H,"C#XZZ"Z雗"EҢI2`X{TuIJ\O}E?J*"z,tee}[=06{ϫƹs-z%ۋݽE]Zֵ81˙cx[&kQw4)쐊r2*Lnmq-RжسC\mfF˭v-8vnvuȇ>YYB'VL!%oJ^moϾ46!DFSfS5ʛ6rXsuGpDD@Q{]N &:30L UZEzoֿ'>{Mkb.aZ[:5]>{Mkbzoֿ "v[:5Z++WؽN,}  OuB͝/4C-{1w=iOX}-|YI޺^i|ZK[S݁FX}-|i@Eע=auk_K|_=1^iOX}-|]z.K|_=1=auk_u謶螑ٺyf,-&*4U"" """"" """"" """"" """"" """"" """"" """Ho*&ro*&ݵ,/ZW""^L}wYFGZZZY+wp#KWS)o)vdYe#V#lr.\驘)hΊ[ZXɷsb+cfu]HBݝd˵[͕K<hږ$WPiei`IJ[$ұڈS2Zq-Rj,6]MeDDLWlLɮ98]݋]_IY-mi6ⴙjgqH7Z_madllif\\@N5$ʑ\w͂k6l v*~ۡ[eҮi-#?%7mu3o7|:#OJsu]R-|f-n4H_ i @\0]%aM[uvZ32#kj7E.m>mz-wT{,4;Vm޹vV,{mkgԛckec8cV&ώ#das _ջ 6=oZ\ZxK[ai7 :G,n>[z*жgkd!mָ-k@&au5qo}UxYd1 -%Pu^mskn-Ip`*RރG!+sM&,ݦqWF_B<+W o2qٸἰ24 kTޑ#e{ŵaEdٵиΕCtB/{f1q=q]L_oY6Ō%c\6emk3#bv+>V]COU{HR*&H2*&]u,/ZW""!e-mgn&bعDWdrS:RE=e-,H䰳mUKM.\L4fCu.a w^ 'b`6V6\%t]m2eY4u8#D͞.l*k{[2λwc]rh}=i32&u͛6?j;W`~bvUA6͏ȑ DbEDU pxݷV3k8S5Ӳk6l8]쩳`!׻X7TwDDv'~N9v'~N9Spt[kk!m$cl2o/7d-q`.$Im@E[de-zupcBַ .s-6@[ؽ6v+"h%X!͐AjIfl,"e^l^ZD~Df ;.ř6f+_ ŋI (ONo.f֡֎ch00%DW%7obV kK;Wl6{Cwkhw_nr\f;KqtqXs  bP{ml텽z6бn~Eʹ|^ +;;\>̿;+F2ɮ vC;6[>XՅo n6ٳNh[ d[&m=Cednk/6b%Sjgںf-og-f"{\Zve^zI[&4fٞpNV@DDDDD@DDDDD@DDDDD@DDDDD@DDDDD@DDDDD@DDDDD@H3/*&/*&]5)zW""Mԅ3Q}/DَmϲMXmCj&]n7~X.ue$OBle͒sl-\vy~wTv6d,[/ʪv\u2_+?Y_ں~mH^^o3 GzuvMetȣ]쩳`!eM9ǼŹ~ע>Dةߧ7U.ע>Dةߧ7U """"" """"" """"" """"" """.סEtتuK])*/w]R"" """"" """"" """"" """"" """"" """"" """H/*&~Q00aO{o"nD2l[Л{EK&",;/ EfaJ l\WtH_-6 Z3ʌbYbZcҒ7/E5`YUrnu͜?j;W`z=ڎD/sWt\]x=~趣wQƻSfC5ʛ6rky]r]D|_SNn]E_.Sze鶎bMhx&\z_B.ka~HOB.ka~HOB.ka~HOB.ka~HOB.ka~HOB.ka~HOB.ka~HOB.ka~HOB.ka~HOB'COU{rE]l/m[؎`֖o$௰GdDD@DDDDD@DEwC1)pc߮AՀ #5] kF 6d (d]XIvB c% .k/>]XIvBEzK%o)/>]"v c% {zK%o(]XIvB c% .k/>]XIvBEzK%o)/>]"v c% {zK%o(]XIvBΕ_x'ٞ;X0⳻Z9Mp-pA@E󨈀I!֖֛8\.l5L{&"ifFwW"" ^a ^b6X=""(0̅+?9,4*U-۲LUM2*oo"̠YRH"52"dCB"""" """"" """"" "a+v^nLx֓hpY_;@^|2z}b@lKphMiiؽM/;m^O~,JZ"TD@DDDDD@DDDDD@DDDDD@DDD]A;av*%}U}vﱅ__1@E ۮξ Cvalzd ,wY_=[vUv!`%}^ WUrgEL+tDDDD@DDDDD@DDDDD@E诓}W' ?Җ:+r&/DDDD@DDDDD@DDDDD@DDDDE@$4I H$vﱅ__1UۣoҬR^~G}}Ksumݷ7 @.p @H5ke|Ż[poCg\ΰZ3Qhmݏ)@E(tD:V}`tu-m6̴z,2Wys]seϴ[wM x"P|/}E筼:mebPz Ԓߥ.ͼ=Av0_@xs&35A@EH%Vwm7ZeEw͡LZS(\zWK\feڋK@ΰxs^ƽ a0C@ip.}QغhmYn/,=C0وbYRIWms鋗]Ѿ1o}wi-EIrDy4'e@zϤzKk81lcAhu3!ğiii|KKKʸYb`k /E .wK/7{/ms6$ؾq lT-TK):шnEOꜶKwT`~Ek{K6Y1TwذV]쩳`)eM9H]{ʹ"" _]o}~jOSY?)tu}m)\/K诓}W' ?Җs>5ӿʅh>5ӿʄ?N*/T?N*\;^VS\;OsyZ "Os>5ӿʅh>5ӿʄ?N*/T?N*\;^VS\;]E{]Lx]=fq۹x 8A `qt?}1KUkuW__1UۣoҬR^~G}}KNYn'GFSY""_cwb[zhu> 1A@E"㠮"ݭllzSGYuEmZ6]nZXI&͏_zFס:*fkvcl1hfxdz:סDl:[;mm-eIsf@k[(5zCYhopy\ mmCf:%Ck룛hpm/i/7u1/EwN{7u}%{-q`kngN!`R*Lp}^ow:bA@jf :$$;_$˥Ｕּ i|%艦kI2L\_{lb뻺 ̷kCWd<4h0%k?%7gH[.vSxt饲.H/*Ȓo*&ݵ,/:W""tuVrhgnc#jG&M&B7!QUψ=vdgȮErni VٴԱקhB6YavaŢ Z ..}WB^`mn"γpd2c+@VW+*+[Ѭ1)v%xqMI!|<\z:6wqfsltH]T] ]2-TvM.^\6qܴ[v[Cte'+UrڙNŧ+?Z2_ꩺxZ VuoukiTŘZ&68a@j'06Wc]쩳`)eM9H{ʽ"" _-:޼_6ihf촃abBQf+;&Xlf!*B>o'؆X kF\C ǴOs7X3ȷl1fZ~tz6Η9n H59GbD@DDDDD@DDDDD@DDDDD@DDD]A;>U߯ͧScK\sLEATr*[-#|R $[OJ[-#|7jm@E/>~O}7jmO[-#|R $[OJ[-#|7jm@E/>~O}7jmO[-#|R $[OJ[-#|7jm@E/>~O}7jmO[-#|R $[OJ[-#|7jm@E/>~O}7jmO[-#|R %/>:Bii o[-#|Ӧ:JՎ^ǂ-\`;(HR*&H2*&]u,/ZW""=I-ei3dR*#jմ"56uS:/2a*-l]ns*+s|S74_Mz1wG^+Kᳱkf,m(>Xt+1Hqga{+K-ehV̺ՋM z=k;86EEʚUϙw3%W`u4!Y6ɫ'\W.u˕6iQR/ͭnq 4]o:f-ċ'0CDP;J_w͂k6l:k~7 ~{auVFe洒G5IgU} \? O"zWTӛvoC…2z} \? O˪_L*d"=`>. dx~.ɔw˅;ՙsC8 -=ئ@E} \? O1p(]?.voC…2z} \? O[F:CX>߫s ] m!JA(OX7B=`>. e". bP&OX7BuHx~.ɓ bP&]R "}`>. dx~.ɗT_X7B=`>. e".ӠVvVj 0,kb" u=,DE7QuΕ}jlͥ ܀8dF{*l!qƻSfCv+nC"" _菑=+*wuK菑=+*wuHnat[൭cZ6 nkԢ/Kn,g:Z"hI-6dE'vOYˡsoX`拫\ǵֿ֒ pu@EVtmo-=,H-$gmѶֶju>/e Rb0ȵc#HH+QuBﵰ0u"up"McZlƱeTat=⃦Cmqey׺"֡ DY}} 1KlC hMuk;ww].pVm4.sn 6%}/_jn-o":X$a,OY5)t[+.,c.z}jɣZ[dD_|>5y& |!6gvVXSoaЗzw+CsV[Yyqv^[kiw@^pqoMt`7]׬u$ϯ&QekKeתw]=ΰ=YӢ ZŚ@DDD]COU{k"SUi^DD@DDDDD@DDDDD@DDDDD@DDDDD@DDDDD@DDDDD@DDDH/*&o*&]5)zW""]Cơş` v;\nZٵWdUzT]\˸J gRG[!}wI^˻:U F;;G1Vm`ak,4f- ghŲsYlUׁNv]7/fNtm:Nȼafzuc]쩳`)eM9Ǽɹ~ע>Dةߧ7U.ע>Dةߧ7U """"" "<\/Vm{^jakl2tC[rY{ϳhgmiյ̐MXM$:}ҬeZY +fټFܴ>-1MtVGW+t2:oԺɭhQfՌilR+Q:K6.{\lxmej-l, p4͡Zg|8ov--gm:ŶEmd0I l $ "NY_'fkvw;;;ˁey}u *12GX6ehxc,ۏ\` q5t0$tIX_:6fo,6@3 s1qk%h^ҟbOu.סEtتuHH dm6V5Tn ٹU5ty,ͫ`f y"/my׼ y׼J|fy)Zp")'SmTȚW{>ȱޖ&t5ڇY't |".ŋU6l]V;@Ȉ:غgy6O/kK TzӸ|_?WT_Zw{zӸ|_?WT_Zw{zӸ|_?WT_Zw{zӸ|_?WT_Zw{zӸ|_?WT_Zw{zӸ|_?WT_Zw{zӸ|_?WT_Zw{zӸ|_?WT_Zw{zӸ|_?WT_Zw{zӸ|_?WTc Y]:wuǪu-//pa{@lX]J""" """"" """"" """"" """"" """"" """"" """@"""" """"" """"" """"" """"" """"" """"" """"" """"" """"" """"" """"" """"" """"" """ endstream endobj 207 0 obj <>stream endstream endobj 107 0 obj <> endobj 103 0 obj <>stream q /GS0 gs /Fm0 Do Q 0 0 0 1 K 1 j 1 J [0 2.997]0 d /GS1 gs q 1 0 0 1 74.3631 630.8533 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 71.3661 630.8533 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q [0 2.997]0 d q 1 0 0 1 74.3631 593.6455 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 71.3661 593.6455 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q 0 j 0 J q 1 0 0 1 70.8661 539.5764 cm 0 0 m 453.543 0 l S Q BT 0 0 0 1 k /T1_0 1 Tf 0.066 Tw 9 0 0 9 119.0551 730.4919 Tm [(of postoperativ)13.1(e bleeding w)13(as 6% \(23/383\) in the open w)12(ound manag)12(ement g)14(roup vs. 3.3% \(14/425\) \(OR 0.47; )]TJ 0.123 Tw 0 -1.111 TD [(95%CI 0.18\2261.26\). The infection rate w)13(as 3.3% \(14/425\) in the sutur)-36.9(ing g)14(roup vs. 1.8% \(7/383\) in the open )]TJ 0.034 Tw T* [(w)12(ound manag)12.1(ement g)14(roup \(OR 1.66; 95%CI 0.69)]TJ /Span<>> BDC ( )Tj EMC [(\227 4.00\). Mean operating time in the g)14(roup with sutur)-36.9(ing of the )]TJ 0.051 Tw T* [(rectal w)12(ound is 7\2268)]TJ /Span<>> BDC ( )Tj EMC [(minutes long)12(er; 95%CI -2.21-17.6. Mean postoperativ)13(e hospital stay for patients in the rectal )]TJ 0.023 Tw T* [(w)12(ound sutur)-36.9(ing g)14(roup w)12.9(as increased by 12 hours.)]TJ 0.033 Tw 0 -1.111 TD [(C)21(ON)22(CLUSION: w)12(ound sutur)-36.9(ing af)-46(ter TEM does no)13(t lead to signif)-43(icant reduction of postoperativ)13(e bleeding and infec)]TJ 0 Tw (-)Tj 0 -1.111 TD (tion.)Tj /T1_1 1 Tf 0.01 Tc -0.01 Tw 8 0 0 8 70.9061 655.2226 Tm [(KEYW)22(ORDS:)]TJ /T1_0 1 Tf 0 Tc 0.023 Tw 4.948 0 Td [( rectal w)12(ound, transanal microsurg)12.1(er)-43(y)42(, TEM, openly manag)12(ement rectal w)12(ound, suture rectal w)12(ound)]TJ /T1_1 1 Tf 0.01 Tc 0.018 Tw -4.948 -1.909 Td [(C)19(ONFL)-33(ICT)5( OF)5( INTE)25(RESTS:)]TJ /T1_0 1 Tf 0 Tc 0.023 Tw 10.423 0 Td [( The authors declare no conf)-22(licts of interest)]TJ /T1_1 1 Tf 0.017 Tc -0.044 Tw -10.423 -2.617 Td [(F)3.5(O)-4.2(R)9( C)-17.2(I)-15.2(T)45.7(A)37.9(T)-24.2(I)-1(O)0.5(N:)]TJ /T1_2 1 Tf 0.003 Tc -0.035 Tw 6.137 0 Td [( S)-1.1(i)-2.8(n)-13.7(i)-15.4(t)-48.6(s)-30.5(y)-27.1(n)]TJ /Span<>> BDC ( )Tj EMC [(R)-21(.K)-26.7(.)-23.1(, A)-11.4(l)-23.3(e)-15.8(k)-39.2(s)-22.6(e)-24.9(e)-15.4(v)]TJ /Span<>> BDC ( )Tj EMC [(M)-6.7(.)40.9(V)40(.)-23.1(, C)-15.5(h)-14.8(e)-11.8(r)-35.5(n)-14.6(y)-28.5(s)-8.5(h)-10.6(o)-9.9(v)]TJ /Span<>> BDC ( )Tj EMC [(S)-9.3(.)41(V)40(.)-23.1(, R)-30(y)-19.2(b)-17.4(a)-10.9(k)-3.3(o)-10(v)]TJ /Span<>> BDC ( )Tj EMC [(E)-5.3(.)15.3(G)-11.2(. I)-29.5(s i)-15.5(t s)-24.4(a)-14(f)-28.2(e t)-21.5(o l)-23.4(e)-12.6(a)-10.4(v)-18.3(e r)-18.8(e)-18.7(c)-41.2(t)-36.4(a)-11.1(l w)-13.1(o)-13(u)-4.7(n)-14.1(d o)-8(p)-24.3(e)-11.2(n)-15.7(e)-20.7(d a)-14(f)-65.9(t)-24.4(e)-11.7(r t)-30.4(r)-30.5(a)-7.3(n)-10.8(s)-24.4(a)-7.2(n)-7.5(a)-11.1(l m)-14.2(i)-4.7(c)-21.9(r)-15.5(o)-15.4(s)-8.5(u)-7.2(r)]TJ 0 Tc 0 Tw 50.199 0 Td (-)Tj 0.001 Tc -0.035 Tw -56.341 -1.2 Td [(g)-14.2(e)-11.9(r)-60.4(y)11.4(? A s)-30.6(y)-28.7(s)-29.1(t)-24.5(e)-11.3(m)-8.1(a)-18(t)-46(i)-4.8(c r)-18.9(e)-15.6(v)-51.6(i)-10.8(e)-12.3(w a)-7.4(n)-14.3(d m)-16.4(e)-22.1(t)-36.6(a)-19.4(-)-12.9(a)-7.4(n)-7.6(a)-11.2(l)-8.1(y)-28.7(s)-25.9(i)-7.3(s)-15.3(. )]TJ /T1_0 1 Tf 0.007 Tc -0.007 Tw [(K)10.1(o)-3.9(lo)-3.9(p)-1.4(r)-0.8(ok)-23(t)-1.6(o)-3.9(lo)-7.1(g)-17(i)2.9(a)2(.)]TJ /T1_2 1 Tf 0.001 Tc -0.035 Tw 25.468 0 Td [( 2)-8.7(0)-3.6(2)9(4)10.4(;)10(2)-10.1(3)6.1(\()37.9(1)44.5(\))14.7(:)21.1(1)-2.2(8)-1.3(1)26.6(\226)51(1)-2.3(8)1.5(7)80.3(. \()-0.8(i)-3(n R)-6.3(u)-21.7(s)-22.1(s)-15.4(.)43.4(\))10.6(. h)-17(t)-49.2(t)-29.2(p)-18.6(s)-7.8(:)2.1(/)84.9(/)36.6(d)-10.9(o)-12.3(i.)2.9(o)-11.6(r)-16.5(g)-22.6(/)11.3(1)14.2(0)6.7(.)-5.4(3)8.1(3)-15.7(8)1.5(7)4.7(8/)8.1(2)-8.7(0)9.5(7)-1.7(3)-13.1(-)41.4(7)10.9(5)0.6(5)-8.8(6)-26.5(-)9.9(2)-8.7(0)-3.6(2)9(4)-28.3(-)]TJ -0.032 Tc 0.032 Tw -25.468 -1.2 Td [(2)-65.3(3)-68.3(-1)-28.1(-1)-57.4(8)-56.4(1)-28.1(-1)-57.4(8)-53.7(7)]TJ /T1_1 1 Tf 0.01 Tc 0.101 Tw 0.005 -2.617 Td [(\026\020\021\033\030)5( \020\036\017)5( \013\033\021\033\013\023\030\037\023:)]TJ /T1_0 1 Tf 0 Tc 0.106 Tw 10.742 0 Td ( \207\025\021\025\203\025\021 \212.\222., \225\210\213\214 \253\217\240\215\ \037 \013\n\023\n\033\032\n\013\024\n\023\n\202\025\025 \025\003\031\021\ \025 \201.\217.)Tj /Span<>> BDC ( )Tj EMC (\212\020\204\025\004\273 \240\025\021\016\030\032\026\027\026 \212\n\t\t\ \025\025, \205\023.)Tj /Span<>> BDC ( )Tj EMC (\207\026\023\002\003\026 \201\030\025\023\002, \030.)Tj /Span<>> BDC ( )Tj EMC (2, )Tj 0.023 Tw -10.747 -1.2 Td (\240\n\t\013\027\026, 123423, \212\n\t\t\025\002; e-mail: eksdeemode@gma\ il.com)Tj /T1_1 1 Tf 0.01 Tc 0.103 Tw 0.005 -1.2 Td [(ADDRESS)5( F)13(OR)5( C)19(ORRESPONDEN)23(CE:)]TJ /T1_0 1 Tf 0 Tc 0.108 Tw 14.221 0 Td [( Sinitsyn R.K., Ryzhikh N)18(ational Medical R)21(esearch Center of Colop)46(roctology)42.1(, Salyama Adilya st., 2, Moscow)52(, )]TJ 0.023 Tw -14.226 -1.2 Td [(123423, R)22(ussia; e-mail: ek)-23(sdeemode@gmail.com)]TJ 0 Tw 0 -2.792 TD (\200\026\024\026 \033\n\t\024\205\033\023\031\021\025\002)Tj /Span<>> BDC ( )Tj EMC (\227 24.10.2023)Tj /Span<>> BDC ( )Tj EMC 19.488 0 Td (\n\t\023\031 \030\n\032\026\005\n\024\013\025)Tj /Span<>> BDC ( )Tj EMC (\227 22.12.2023)Tj /Span<>> BDC ( )Tj EMC 18.78 0 Td (\032\025\021\002\024\n \013)Tj /Span<>> BDC ( )Tj EMC (\033\205\005\023\025\013\026\203\025\025)Tj /Span<>> BDC ( )Tj EMC (\227 12.02.2024)Tj ( )Tj -38.268 -1.375 Td (Received)Tj /Span<>> BDC ( )Tj EMC (\227 24.10.2023)Tj /Span<>> BDC ( )Tj EMC 19.488 0 Td (Revised)Tj /Span<>> BDC ( )Tj EMC (\227 22.12.2023)Tj /Span<>> BDC ( )Tj EMC 18.78 0 Td (Accepted for publication)Tj /Span<>> BDC ( )Tj EMC (\227 12.02.2024)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 70.936 481.2699 Tm (\023\023\034\226\034\022\031\034)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf 0 Tc 0.218 Tw 10 0 0 10 70.8661 456.9139 Tm (\217\026\030\026\002\024\021\026\027\027\026\016 \r)Tj /Span<>> BDC ( )Tj EMC (1984 \020. Buess G. \n\036\021\024\007\017\022\026 \021\030\026\027\f)Tj 0 Tw (-)Tj 0.216 Tw 0 -1.218 TD [(\026\027\026\035\034\027\024\005 \220\027\007\024\n\017\022\030\024\b\017\ \030\031\030\020\017\017 )0.5(\(\230\224\204\) \023\024\r\024\035\017\035\026 )0.5(\r\t)]TJ 0 Tw (-)Tj 0.332 Tw T* [(\023\024\035\027\016\021\034 )0.6(\023\030\036\006\017\017\024\027\027\024\036 )0.5(\031\007\026\035\036\027\017\036 )0.5(\027\024\r\024\024\002\030\026\024\r\026\027\017\005 )]TJ 0 Tw T* (\r\024 \r\f\036\b \024\021\007\036\035\026\b \023\030\016\n\024\005 \022\ \017\001\022\017 [1,2].)Tj -0.006 Tw T* (\215\024 \007\026\027\027\t\n \035\017\021\036\030\026\021\031\030\t, \n\ \036\021\024\007\017\022\026 \023\024\035\027\024\f\021\036\027\027\024\020\ \024 \031\007\026)Tj 0 Tw (-)Tj 0.014 Tw T* (\035\036\027\017\016 \027\024\r\024\024\002\030\026\024\r\026\027\017\005\ \023\030\016\n\024\005 \022\017\001\022\017 \027\017\032\036 \023\036\030\ \017\021\024)Tj 0 Tw (-)Tj 0.001 Tw T* (\027\036\026\035\034\027\024\005 \f\022\035\026\007\022\017)Tj /Span<>> BDC ( )Tj EMC (\227 \002\036\024\023\026\f\027\024\036 \b\017\030\031\030\020\017\004\036\ \f\022\024\036 \r\n\036)Tj 0 Tw (-)Tj -0.039 Tw T* (\001\026\021\036\035\034\f\021\r\024, \f\r\016\026\027\027\024\036 \f)Tj /Span<>> BDC ( )Tj EMC (\027\017\022\017\n \031\030\024\r\027\036\n \024\f\035\024\032\027\036\027\ \017\005 )Tj -0.017 Tw T* ([20]. \230\026\022, \023\024)Tj /Span<>> BDC ( )Tj EMC (\007\026\027\027\t\n \223\036\030\027\t\001\024\r\026 \221.\200. [19], \f\ \031\n\n\017\030\031\033)Tj 0 Tw (-)Tj 0.095 Tw T* (\013\036\020\024 \024\023\t\021 \r\t\023\024\035\027\036\027\017\016 600\ \021\030\026\027\f\026\027\026\035\034\027\t\b \220\027\007\024\f\022\024\ )Tj 0 Tw (-)Tj -0.017 Tw T* (\023\017\004\036\f\022\017\b \024\023\036\030\026\006\017\005 \f)Tj /Span<>> BDC ( )Tj EMC (\031\001\017\r\026\027\017\036\n \023\024\f\035\036\024\023\036\030\026\006\ \017\024\027\027\024\005 )Tj 0.054 Tw T* (\030\026\027\t, \004\026\f\021\024\021\026 \022\035\017\027\017\004\036\f\ \022\017 \027\026\004\017\n\t\b \024\f\035\024\032\027\036\027\017\005 \ \023\024)Tj 0 Tw (-)Tj 0.201 Tw T* (\f\035\036 \230\224\204 \f\024\f\021\026\r\035\016\036\021 3,6%. \222)Tj /Span<>> BDC ( )Tj EMC [(\027\017\b \027\026\017\002\024\035\036\036 )0.5(\004\026\f\021\t\n )]TJ -0.003 Tw T* (\002\t\035\024 \022\030\024\r\024\021\036\004\036\027\017\036)Tj /Span<>> BDC ( )Tj EMC (\227 1,2%, \026)Tj /Span<>> BDC ( )Tj EMC (\004\026\f\021\024\021\026 \017\027\235\036\022\006\017\024\027\027\t\b \ )Tj 0 Tw T* (\024\f\035\024\032\027\036\027\017\005 \f\024\f\021\026\r\017\035\026 1%\ .)Tj 0.214 Tw T* (\203\036\f\n\024\021\030\016 \027\026)Tj /Span<>> BDC ( )Tj EMC (\027\017\022\031\033 \004\026\f\021\024\021\031 \024\f\035\024\032\027\036\ \027\017\005 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\230\224\204, )Tj 0.362 Tw T* [(\024\f\021\026\036\021\f\016 )0.6(\024\021\022\030\t\021\t\n )0.5(\r\024\023\030\024\f )0.5(\r\027\036\007\030\036\027\017\016 )0.6(\r)]TJ /Span<>> BDC ( )Tj EMC 18.339 0 Td (\001\017\030\024\022\031\033 )Tj 0.292 Tw -18.339 -1.218 Td [(\023\030\026\022\021\017\022\031 )0.5(\007\026\027\027\024\005 \n\036\021\024\007\017\022\017 )0.5([18]. )0.5(\203\036 \r)]TJ /Span<>> BDC ( )Tj EMC (\023\024\f\035\036\007\027\033\033 )Tj 0.028 Tw T* (\024\004\036\030\036\007\034 \220\021\024 \f\r\016\026\027\024 \f)Tj /Span<>> BDC ( )Tj EMC (\235\024\030\n\017\030\024\r\026\027\017\036\n \220\027\007\024\f\022\024\ \023\017\004\036)Tj 0 Tw (-)Tj 0.048 Tw T* (\f\022\024\020\024 \001\r\026 \r)Tj /Span<>> BDC ( )Tj EMC (\024\020\030\026\027\017\004\036\027\027\024\n \023\030\024\f\021\030\026\ \027\f\021\r\036, \004\021\024 \016\r\035\016\036\021)Tj 0 Tw (-)Tj -0.027 Tw T* (\f\016 \021\036\b\027\017\004\036\f\022\017 \f\035\024\032\027\024\005 \n\ \026\027\017\023\031\035\016\006\017\036\005. \200)Tj /Span<>> BDC ( )Tj EMC (\021\024 \032\036 \r\030\036\n\016, )Tj 0.177 Tw T* (\036\007\017\027\024\020\024 \n\027\036\027\017\016 \024)Tj /Span<>> BDC ( )Tj EMC (\027\036\024\002\b\024\007\017\n\024\f\021\017 \031\001\017\r\026\027\017\ \016 \023\024\f\035\036)Tj 0 Tw (-)Tj 0.191 Tw T* (\024\023\036\030\026\006\017\024\027\027\024\005 \030\026\027\t \023\024\ \f\035\036 \230\224\204 \027\036\021. \210\007\027\017\n \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\036)Tj 0 Tw (-)Tj -0.029 Tw T* (\017\n\031\013\036\f\021\r \r\036\007\036\027\017\016 \030\026\027\t \024\ \021\022\030\t\021\t\n \f\023\024\f\024\002\024\n \016\r\035\016\036\021\ \f\016 )Tj -0.04 Tw T* (\f\024\022\030\026\013\036\027\017\036 \r\030\036\n\036\027\017 \024\023\ \036\030\026\006\017\017 [5]. \221)Tj /Span<>> BDC ( )Tj EMC (\007\030\031\020\024\005 \f\021\024\030\024\027\t, )Tj 0.029 Tw T* [(\f\004\017\021\026\036\021\f\016, )0.5(\004\021\024 \031\001\017\r\026\027\017\036 \007\036\235\036\022\021\026\ )0.5(\023\030\016\n\024\005 \022\017\001\022\017 )0.5(\024\002\036)]TJ 0 Tw (-)Tj 0.201 Tw T* (\f\023\036\004\017\r\026\036\021 \002\024\035\036\036 \027\026\007\036\032\ \027\t\005 \020\036\n\024\f\021\026 \017)Tj /Span<>> BDC ( )Tj EMC (\026\032\017\r\035\036\027\017\036 )Tj 0.149 Tw T* [(\023\036\030\r\017\004\027\t\n )0.5(\027\026\021\016\032\036\027\017\036\n, )0.5(\026)]TJ /Span<>> BDC ( )Tj EMC [(\021\026\022\032\036 \f\027\017\032\026\036\021 )0.5(\030\017\f\022 )0.5(\030\026)]TJ 0 Tw (-)Tj T* (\r\017\021\017\016 \f\021\036\027\024\026 \023\030\016\n\024\005 \022\017\ \001\022\017 [6].)Tj 0.251 Tw T* [(\212\026\027\027\t\005 \f\017\f\021\036\n\026\021\017\004\036\f\022\017\005\ )0.5(\024\002\024\030 \035\017\021\036\030\026\021\031\030\t )0.5(\023\024\f\r\016)]TJ 0 Tw (-)Tj 0.145 Tw T* (\013\036\027 \f\030\026\r\027\036\027\017\033 \030\036\031\035\034\021\026\ \021\024\r \035\036\004\036\027\017\016 \023\026\006\017\036\027\021\024\ \r \023\024)Tj 0 Tw (-)Tj 0.058 Tw T* (\f\035\036 \021\030\026\027\f\026\027\026\035\034\027\024\005 \220\027\007\ \024\n\017\022\030\024\b\017\030\031\030\020\017\017 \f)Tj /Span<>> BDC ( )Tj EMC (\031\001\017\r\026\027\017\036\n )Tj -0.002 Tw 23.244 40.187 Td [(\023\024\f\035\036\024\023\036\030\026\006\017\024\027\027\024\005 )0.6(\030\026\027\t )0.5(\023\030\016\n\024\005 )0.6(\022\017\001\022\017 )0.5(\017\035\017 )0.5(\r\036\007\036\027\017)]TJ 0 Tw (-)Tj T* (\036\n \036\036 \024\021\022\030\t\021\t\n \f\023\024\f\024\002\024\n.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0.01 Tc 0.018 Tw 14 0 0 14 303.3769 432.5579 Tm [(\240)21(\026)45(\024\034\033\031\026)-10(\r\232)5( \031)5(\016)-18.3(\240\034)-31(\024)35(\037\226\232)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf 0 Tc 0.419 Tw 10 0 0 10 303.3071 408.2019 Tm (\221\017\f\021\036\n\026\021\017\004\036\f\022\017\005 \024\002\024\030\ \r\t\023\024\035\027\036\027 \r)Tj /Span<>> BDC ( )Tj EMC (\f\024\024\021\r\036\021\f\021\r\017\017 )Tj 0.468 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC [(\030\036\022\024\n\036\027\007\026\006\017\016\n\017 P)35(r)-24(efer)-24(r)-23.9(ed R)13(epor)-22(t)-32(ing Items for )]TJ 0.624 Tw T* [(Sy)-13(stema)15.1(t)-32(ic R)13(ev)-16(iews and Me)-12(t)15(a-Anal)35(y)-13(ses \(PRISMA\) )]TJ 0.329 Tw T* (\023\030\017)Tj /Span<>> BDC ( )Tj EMC [(\023\024\n\024\013\017 \023\024\017\f\022\024\r\t\b \f\017\f\021\036\n E\ l)-31(ibr)-32.9(ar)-24(y, Co)-16(chr)-33(ane, )]TJ 0.168 Tw T* (PUBMED \r)Tj /Span<>> BDC ( )Tj EMC [(\220\035\036\022\021\030\024\027\027\024\005 \002\026\036 Medl)-31(ine \002\036 \024\020\030\026\027\017\004\036)]TJ 0 Tw (-)Tj 0.131 Tw T* (\027\017\016 \007\026\021\t \023\031\002\035\017\022\026\006\017\017. \215\ \024\017\f\022 \017)Tj /Span<>> BDC ( )Tj EMC (\024\021\002\024\030 \f\021\026\021\036\005 \023\030\024\r\024)Tj 0 Tw (-)Tj 0.042 Tw T* (\007\017\035\f\016 \027\026)Tj /Span<>> BDC ( )Tj EMC [(\024\f\027\024\r\036 PIC)13(O-\n\024\007\036\035\017 \(\230\026\002\035.)]TJ /Span<>> BDC ( )Tj EMC (1\) \023\024)Tj /Span<>> BDC ( )Tj EMC (\022\035\033\004\036\r\t\n )Tj -0.003 Tw T* [(\f\035\024\r\026\n: \253tr)-33(ansanal end)-16(oscopic micr)-31.9(osur)-32(ger)-24(y\273, \253TEMS\273, )]TJ -0.019 Tw T* [(\253T)35(AMIS\273, \253r)-24(ec)-16(t)15(al defec)-16(t \(sutur)-24(ed or open\)\273. \200)]TJ /Span<>> BDC ( )Tj EMC (\017\f\f\035\036\007\024)Tj 0 Tw (-)Tj 0.055 Tw T* (\r\026\027\017\036 \r\024\001\035\017 \023\024\035\027\024\021\036\022\f\ \021\024\r\t\036 \f\021\026\021\034\017. \207\t\035\017 \017\f\022\035\033\ \004\036)Tj 0 Tw (-)Tj 0.024 Tw T* (\027\t \017)Tj /Span<>> BDC ( )Tj EMC (\023\024\017\f\022\026 \f\035\036\007\031\033\013\017\036 \023\031\002\035\ \017\022\026\006\017\017: \026\002\f\021\030\026\022\021\t, \024\002)Tj 0 Tw (-)Tj 0.153 Tw T* [(\024\030\t )0.5(\035\017\021\036\030\026\021\031\030\t, )0.6(\024\023\036\030\026\006\017\017 )0.5(\027\026)]TJ /Span<>> BDC ( )Tj EMC 13.471 0 Td [(\032\017\r\024\021\027\t\b, )0.6(\023\017\035\024\021\027\t\036 )]TJ 0.034 Tw -13.471 -1.218 Td (\017\f\f\035\036\007\024\r\026\027\017\016 \002\036 \020\030\031\023\023\ \f\030\026\r\027\036\027\017\016, \024\023\017\f\026\027\017\036 \022\035\ \017\027\017)Tj 0 Tw (-)Tj T* (\004\036\f\022\017\b \f\035\031\004\026\036\r.)Tj 0.081 Tw T* (\215\024\f\035\036 \023\030\024\r\036\007\036\027\017\016 \023\024\017\f\ \022\026 \002\t\035\024 \024\002\027\026\030\031\032\036\027\024 134 \023\ \031)Tj 0 Tw (-)Tj 0.327 Tw T* (\002\035\017\022\026\006\017\017. \215\030\017)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\r\017\004\027\024\n \026\027\026\035\017\036 \002\t\035\017\ \031\007\026\035\036\027\t )Tj 0.059 Tw T* [(33 )0.5(\f\021\026\021\034\017 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 5.011 0 Td [(\007\031\002\035\017\022\026\021\t. )0.5(\215\024\f\035\036 )0.5(\024\021\002\024\030\026 \017)]TJ /Span<>> BDC ( )Tj EMC 11.67 0 Td [(\031\007\026\035\036\027\017\016 )0.5(\007\031)]TJ 0 Tw (-)Tj 0.154 Tw -16.681 -1.218 Td (\002\035\017\022\026\021\024\r \024\002\013\036\036 \022\024\035\017\004\ \036\f\021\r\024 \f\021\026\021\036\005 \f\024\024\021\r\036\021\f\021\r\ \024\r\026\035\024 )Tj -0.016 Tw T* (101. \212\026\035\036\036 \023\030\024\r\036\007\036\027 \023\024\007\030\ \024\002\027\t\005 \026\027\026\035\017, \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\022\024\021\024\030\024\n )Tj 0.066 Tw T* (\002\t\035\024 \031\007\026\035\036\027\024 95 \017\f\f\035\036\007\024\r\ \026\027\017\005, \027\036 \f\024\024\021\r\036\021\f\021\r\031\033\013\017\ \b )Tj 0.016 Tw T* (\006\036\035\017 \n\036\021\026\026\027\026\035\017\026. \230\026\022\017\ \n \024\002\030\026\024\n, \007\035\016 \007\026\027\027\024\020\024 \n\ \036\021\026)Tj 0 Tw (-)Tj 0.062 Tw T* (\026\027\026\035\017\026 \002\t\035\024 \024\021\024\002\030\026\027\024\ 6 \f\030\026\r\027\017\021\036\035\034\027\t\b \017\f\f\035\036\007\024\ \r\026)Tj 0 Tw (-)Tj 0.019 Tw T* (\027\017\005)Tj /Span<>> BDC ( )Tj EMC 1.799 0 Td (\227 3 \030\036\021\030\024\f\023\036\022\021\017\r\027\t\b [6,7,16], \024\ \007\027\024 \023\030\024\f\023\036\022\021\017\r)Tj 0 Tw (-)Tj -0.029 Tw -1.799 -1.218 Td (\027\024\036 [8] \017)Tj /Span<>> BDC ( )Tj EMC (\007\r\026 \030\026\027\007\024\n\017\017\030\024\r\026\027\027\t\b \017\ \f\f\035\036\007\024\r\026\027\017\016 [5,9] )Tj 0 Tw T* (\(\217\017\f.)Tj /Span<>> BDC ( )Tj EMC (1\).)Tj 0.274 Tw T* (\200\f\036 \026\r\021\024\030\t \r)Tj /Span<>> BDC ( )Tj EMC (\017\f\f\035\036\007\024\r\026\027\017\016\b, \r\022\035\033\004\036\027\ \027\t\b \r)Tj /Span<>> BDC ( )Tj EMC (\n\036\021\026)Tj 0 Tw (-)Tj 0.467 Tw T* (\026\027\026\035\017, \017\f\023\024\035\034\024\r\026\035\017 \f\021\026\ \027\007\026\030\021\027\031\033 \n\036\021\024\007\017\022\031 \r\t)Tj 0 Tw (-)Tj 0.431 Tw T* (\023\024\035\027\036\027\017\016 \021\030\026\027\f\026\027\026\035\034\027\ \024\005 \220\027\007\024\n\017\022\030\024\b\017\030\031\030\020\017\004\ \036\f\022\024\005 )Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 0 Tw 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\214)10(\211\036\033 \035\030\032\t\033)30(\b)42(\032)-21(\240\033\233)]TJ 57.136 0 Td (REVIEW)Tj -57.136 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 23, \023\0221)69(, 202)69(4)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 23, \023\0221)69(, 202)69(4)]TJ /T1_5 1 Tf 25 0 0 25 20.7902 56.0378 Tm (182)Tj ET endstream endobj 96 0 obj <> endobj 208 0 obj <> endobj 209 0 obj <> endobj 210 0 obj <>stream H\ˮ0<,F"E/j H ByJEJ3aL;O}7440k׷Sx ϩ n]hڮ3o1z~C^GzޓԆos{gFR_{P}x_1_sMfhc0-$,>c~av6)l"`K`G+r.{';p)lW,[a};\Frd1L55 jL#גKz5 7艦ԨoodkɥFg✋&-yEFeE5d8؜kknvEFmA-%xKݑ.잌^u#±Z}|}|V| *~ 0ǚ3#s?3 s/3,^e+0|2\sU.>[y/K?V6ED}9MqF>stream HU PT>W8T\{W0Q^Eh@F","IFSMXMl:VIBMghw;wη?."3Җ/[4:p]aQqavkc /Z{EW- ӓdߓY/jp_̡'GF E ` A<fy`)X [` Hw^~ ΀ n߃Hӌ &h$jV,ADf:af:`E㙠LL%o敘J sK˲&wIm"sqi0הU<4 {)=77/; KS,6+)5sLY9f| 4 k>7+lJ),.*,~.8)m_nf1w(@x&@#7 ӂA(S;%j7AAeWD߄ ]xLx(lPآS^tG;6x?I39Iwؤaa_PjswX5;"9ݐf8m5>FzGaď69%1Ec}ө=ߍ27/V좥% hx9gVCNi^dх0Yb^ Vnmp( >\nIb.A(7Uг;$VUxcQ- |%a3q*l 6:|5fH& o%Q.lydKVx%NZ3͂vTHh9wQ˱]ful ^ E;t,_byǚG?8%w];rrWFx'!7yEN`3"a"Qfsq,Eh;,׻dq}lokh4HhX =xe^Cጾ9 bQO4kݿbs_=]Gr6C9?Sh9aKs91^D.gRT}35ou`0|Fnx%iNaɜ7=Bxi% \KjH xU/Fi$ū סK-4/Cn 뭢ѩpy:2>wഷ~Mgf$iV RHl{7O33jM,[n'}4dH[yF$5j];mۭ÷3;O\OǪZ ;[ZhScA͛ܨ..D}zw-Ŕ<~p" mbuъ"2zmn^aHeVGOf涫JGNR%FMQC||/|˂߀.A,:ւ^t,+XTqV;K"<Eŏ6b1V%Tg$=!_'k,^r68+(u!p8ݳwFKN>˩0û:w5H|M^y5߰ _+&ZTsױ]bu?ڗwV: ƞ}RIMŵFlS.Y%15SM[%϶XM+K.nz)%_|-Lә%1Ed 5o?4WscɧO3;nxq߱5$hhvU9uIuc:F?.`/M):q\rwy0}X ̱%Qb4FUUq3ЯwC67H,kvUp,"DEk"k91vi-ҥw'Vr ja D\ˢ8kIF916׀ MK 1;A6?OB,z;Љ(WXd=nWYөۏm]$5 fڍ7a|ʸ.^6䜖2;F0m8`W:cf]6a`z_wJ:".q|j8-4r"P< 4HvL*D/ rz )eE} 6n0~NPLBZFJs3?uҰ/gPEyNz r:~}rӗ t&fa3 7K^y/)D[9^.9ND\b|hCԓp쥂l">3VhN4f(ib,[纯%OUu>RSl|<炻P֪85F] 4PU`1UAB=p,WO4 |ښ=8tTdCag%o IRw40y bvo+b6O%poۻ@0#!SrnX.O5:Z܇ȫcA Z8)sdH$6&M羡K/]i'KrtH~gd%hg&Cd2wV70A44G "o+!qf= FjTr/v+Yekr튧fPdC\+}8 ~Ws+;4XT-)>n"NAtVqI9kPc9@A\ch/X3a#4ux p/To7.IK+'"[.W4 Ke3f8C| "?D|qH #5Rc|0m$ Dj92e&6?D5OA|+Xp7̛et=»" `>i:qǬ/- 3HMܑK6!lWhE⥝vhaQW9MWVSfzHR%WS7{rf ZCJ5{𴶄gz{_Uƒo zs.["|2sk>*VDZ:o'S m w8|Pu$U(/tn$~ X>Zy(֫oڲd{qh 1(j6(5#@ć}uמ;7cᶡk#heMx 8YRQnQB| a%w^>}huXCz0m2WϳeSԨqWАHT?0"uJ9$(DBE2V`28>UXVBs Ekd*5kUxlgf_))%{ L! $2XR[QtQB՝ 5j5^1n'Cֲ:6m5j|D[(.ݻwwY ,~ GASGHF(12{LAm&{9}'&r+găgK<ܩ:Y_Xeb%N?צ%q%vHB"Ǟ`11$:CzNZF@Df 1iZKWcZA~ߪX L\q1:@0-qoRyN^{Vaf{-~b.=ƀž]b%y@HN. rDw`8jl-YfdԁhWeѤC,bV~(_;;p؛`SpjQz=`ݘ$MԱв'-?̂FՃD.^M7`,ҧUit.|VsLCW,sQ9An4_TMIMb)5[j[U0 كKî^r:9il7'߬Λ3$9vU! !:Ȫ+Ң߭K\d5p_8B忀=`\V?3TwgR4HtL7]dUe1,#o{>4<\ci2Fґ3Qeht0.cUJ %s .%Gti&edg0b /y2v!{6ֱ6Gi/ y 㴥2-&p̳Zjzn15.VEuE0ȷJn5-qZ2{6Cdn9. lFrH\Y}o9{.|oީ9h}Rڈ ; a6~kvE発|#FQT0htnt#8/Rq<D W`gĩtTXiK,pBEAmBu_!M9W\PKA._ڝx)-D#Ov4Y1 KQ#P+^Ji/bxOq+`mq|vkE'n"2U˪w0VUċNc+E%^|pL0?a~zWKXV)l0q7yufwѥd{w.e>W:p0 4$m"p9ujLFG-WCku{A{cYw՛PfDk=G@BSy#xۂ̢aK*uQNUg)QK@*ku8ｮC.}}Eg͜$m"9zZzhaGQwCuBh΃-N_+09W 8Lz GM~te~MьA]OsNd!X۳t,zX/7e w5V>-p{lkYA=hhwW21h91mVrK[aWdE ;W^xN?iaGZ-"g#ѫQ: j*`"@a.Uhx o h1?,XT# -t=:{&\&>8"h+i}` gr[:ؿj֝JF-^T'pF\M,$ )j[f C 6]mK ٦A7a_ rEYd%o-6*eDyј^FbJҠD%D(.-[ w;3;;g朹JBDDҤ AL̬N=%pѺr*"`%$2 HFr$f[&n zxޙ>A8فAV8qϴz6oC"p4R[zHsZDq|sz4ՔDnt@]Mr/aQk5Y󪒒BbLeAg`X 2veWxohtms/ѺA)S"CuА *)b7-fu1L㏙@3:DlL 9#RX0qO/T,df t#Q6CQ [0fpx]HAHquDd/u"bkK[vƂD/)$C?o^7ǾNh(ː*UhOv7~q&Z*멹]?r~軌i27%ֳqH ?9*ѓQfk`uYmT3ὕTX[`6˹]Рfmy1GtҬl?m &&:ՓV9C@5eA*̙%}vw*,5cKK s %aR[G"\nUWF<\ l1Oau6 P{,l5С&-u`2(BVȎ`mS)b7g@/$r#[$v!\սCD[*(oXKeXUPhFS oeX8]p80OM~>zOً+ Yw, 11,ǪH =)Fv8`j2Wܾi4)5z%i]r(E4lv׼mSx5C>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\214\016\222\025\221\013\006\001\025 \007\220 \025\006)-10(\026)11(\013\r\007\205\026\216 \002\013\001\215 \221\002\205\024\025\203 \n\220\ \n\220 \221\025\006)-9.9(\007\016 \026\002\013\001\006\013\001\013\007\216\001\025\203 )]TJ 0 -1 TD [(\232\001\201\025\024\220\n\002\025\207\220\002\215\002\202\220\220 \025\026\ \n\002\020\026)11.1(\025\203? \(\006\220\006)-10(\026)11(\016\024\013\026\220\017\016\006\n\220\203 \025\f\222\025\002 \220\022\024\ \016\026)11(\013\013\001\013\007\220\222\))]TJ 39.202 1 Td [(Is it safe to leav)12.1(e r)31(ectal w)11(ound opened af)-31(ter tr)21(ansanal )]TJ -0.067 -1 Td [(micr)20(osur)31.1(ger)-31(y? A s)10.1(y)9.9(stematic r)31(e)11(vie)11(w and meta-analy)10.1(sis.)]TJ ET 0 0 0 1 K 1 j 1 J [0 2.997]0 d /GS1 gs q 1 0 0 1 46.0167 344.1411 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 43.0197 344.1411 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q [0 2.997]0 d q 1 0 0 1 46.0167 306.9332 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 43.0197 306.9332 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q BT 0 0 0 1 k /T1_1 1 Tf 10 0 0 10 42.5197 724.8299 Tm (https://doi.org/10.33878/2073-7556-2024-23-1-181-187)Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 0.023 Tw 19 0 0 19 69.9201 695.3259 Tm [(\214\016\222\025\221\013\006\001\025 \007\220 \025\006)-10(\026)11(\013\r\007\205\026\216 \002\013\001\215 \221\002\205\024\025\203 \n\220\ \n\220 \221\025\006)-10(\007\016 )]TJ 0.746 -1.105 Td [(\026\002\013\001\006\013\001\013\007\216\001\025\203 \232\001\201\025\024\ \220\n\002\025\207\220\002\215\002\202\220\220 \025\026\n\002\020\026)11.1(\025\203? )]TJ 1.554 -1.105 Td [(\(\006\220\006)-10(\026)11(\016\024\013\026\220\017\016\006\n\220\203 \025\f\222\025\002 \220\022)-23.2(\024\016\026)11(\013\013\001\013\007\220\222\))]TJ 0 0 0 1 k /GS1 gs 0 Tw 14 0 0 14 42.5197 628.822 Tm [(\021\220\001\220\227\020\001\022)-23.2(\033)124(.\037.)]TJ 8.162 0 0 8.162 118.2909 633.484 Tm (1)Tj 0.023 Tw 14 0 0 14 122.9269 628.822 Tm [(, \b)-21(\007\016\n\006\016\016\r\022)-23.2(\005.\004.)]TJ -0.069 Tc 0.069 Tw 8.162 0 0 8.162 215.4874 633.484 Tm [(1,)-69(2)]TJ 0 Tc 0.023 Tw 14 0 0 14 226.808 628.822 Tm [(, \003\016\002\001\020\025\r\022)-23.2(\021.\004.)]TJ 0 Tw 8.162 0 0 8.162 322.6308 633.484 Tm (1)Tj 0.023 Tw 14 0 0 14 327.2668 628.822 Tm [(, \033\020\f\013\n)10(\025\r\022)-23.2(\t.\031)72(.)]TJ 0 Tw 8.162 0 0 8.162 407.2981 633.484 Tm (1)Tj 5.83 0 0 5.83 42.5197 614.4827 Tm (1)Tj 0.023 Tw 10 0 0 10 45.8311 611.1527 Tm [(\210\031\214)42(\240 \253\213\005\030\226 \n)10(\025\007\025\221\002\025\n)-9.9(\026)11(\025\007\025\202\220\220 \220\024\016\001\220 \b)-30.9(.\213.\022)-23.3(\033\020\217\220\207\273 \005\220\001\222\201\002\013\r\013 \033\025\006\ \006\220\220 \(\215\007.\022)-23.3(\021\013\007\205\024\013 \b)-20.9(\201\220\007\205, \201.\022)-23.3(2, \202)62.1(.\022)-23.3(\005\025\006\n\r\013, )]TJ -0.331 -1.2 Td [(1)125(23)58(423, \033\025\006\006\220\205\))]TJ 0 Tw ( )Tj 5.83 0 0 5.83 42.5197 590.4827 Tm (2)Tj 0.023 Tw 10 0 0 10 45.8311 587.1527 Tm [(\210\031\214)21(\036)20(\240 \255\034\036 \033)21(\005\b\213\034\036 \005\220\001\222\201\002\013\r\013 \033\025\006\006\220\ \220 \(\215\007.\022)-23.2(\214\013\002\002\220\n\013\201\001\013\205, \201.\022)-23.3(2/1)69(, \006)-10(\026\002)-31(.\022)-23.3(1)69(, \202)62(.\022)-23.2(\005\025\006\n\r\013, 1)125(2)23(5)23(99)35(3, \033\025\006\006\220\205\))]TJ /T1_1 1 Tf 0.112 Tw 9 0 0 9 90.7087 568.6488 Tm (\216\216\036\200\036\217\215\036: \021\031 \t\205\211\031\t\024\027\205\031\ \024 \031\030\025\021\n\202\n \003\021\031\021\025\002 \n)Tj /Span<>> BDC ( )Tj EMC (\021\031\n\005\004\n\030\025\003\n\t\024\025 \205\001\025\027\026\021\025\ \002 \032\026\021\020 \033\032\002\003\n\017 \013\025\001\013\025 \033\n\ \t\023\031 \024\032\026\021\t)Tj 0 Tw (-)Tj 0.183 Tw 0 -1.111 TD (\026\021\026\023\022\021\n\017 \r\021\030\n\003\025\013\032\n\004\025\032\ \205\032\202\025\025 \(\220\230\240\). \212\031\016\205\023\022\024\026\024\ \020 \025\t\t\023\031\030\n\027\026\021\025\017 \033\n)Tj /Span<>> BDC ( )Tj EMC (\023\031\006\031\021\025\007 \033\026\203\025\031\021\024\n\027 \033\032\ \025)Tj /Span<>> BDC ( )Tj EMC (\027\031\030\031\021\025\025 \032\026\021 )Tj 0.023 Tw T* (\n\024\013\032\020\024\020\003 \025)Tj /Span<>> BDC ( )Tj EMC (\016\026\013\032\020\024\020\003 \t\033\n\t\n\005\n\003 \033\032\031\030\ \t\024\026\027\023\031\021\020 \027)Tj /Span<>> BDC ( )Tj EMC (\030\026\021\021\n\003 \003\031\024\026\026\021\026\023\025\016\031. )Tj T* (\037\036\035\034 \215\207\207\035\036\200\255\216\201\217\215\243: \t\032\ \026\027\021\025\024\022 2 \003\031\024\n\030\026 \027\031\030\031\021\025\ \002 \032\026\021\020 \033\032\002\003\n\017 \013\025\001\013\025 \205)Tj /Span<>> BDC ( )Tj EMC (\033\026\203\025\031\021\024\n\027 \033\n\t\023\031 \220\230\240. )Tj 0.08 Tw T* (\240\201\220\036\212\215\201\035\235 \215)Tj /Span<>> BDC ( )Tj EMC (\240\036\220\255\200\235: \t\025\t\024\031\003\026\024\025\006\031\t\013\ \025\017 \n\005\016\n\032 \025)Tj /Span<>> BDC ( )Tj EMC (\003\031\024\026\026\021\026\023\025\016 \027\020\033\n\023\021\031\021 \ \027)Tj /Span<>> BDC ( )Tj EMC (\t\n\n\024\027\031\024\t\024\027\025\025 \t)Tj /Span<>> BDC ( )Tj EMC (\032\031\013\n\003\031\021\030\026\203\025)Tj 0 Tw (-)Tj 0.023 Tw 0 -1.111 TD (\002\003\025 PRISMA. )Tj -0.022 Tw 0 -1.111 TD [(\212\036\221\214\035\034\220\201\220\235: )0.6(\n\024\n\005\032\026\021\n )0.6(6 )0.6(\025\t\t\023\031\030\n\027\026\021\025\017 )0.6(\016\026)]TJ /Span<>> BDC ( )Tj EMC 17.633 0 Td [(\033\031\032\025\n\030 )0.6(\t)]TJ /Span<>> BDC ( )Tj EMC 3.714 0 Td [(2002 )0.5(\033\n)]TJ /Span<>> BDC ( )Tj EMC 3.402 0 Td [(2021 )0.5(\202\202. )0.6(\216)]TJ /Span<>> BDC ( )Tj EMC 4.255 0 Td [(\003\031\024\026\026\021\026\023\025\016 )0.5(\027\013\023\007\006\031\021\n )0.5(808 )0.6(\033\026\203\025\031\021\024\n\027: )]TJ 0.027 Tw -29.004 -1.111 Td (\205)Tj /Span<>> BDC ( )Tj EMC (383)Tj /Span<>> BDC ( )Tj EMC (\(47%\) \033\026\203\025\031\021\024\n\027 \032\026\021\026 \033\032\002\ \003\n\017 \013\025\001\013\025 \027\031\023\026\t\022 \n\024\013\032\020\ \024\020\003 \t\033\n\t\n\005\n\003, \205)Tj /Span<>> BDC ( )Tj EMC (425)Tj /Span<>> BDC ( )Tj EMC (\(53%\) \033\026\203\025\031\021\024\n\027)Tj /Span<>> BDC ( )Tj EMC (\227 \205\001\025\027\026)Tj 0 Tw (-)Tj 0.072 Tw T* (\023\026\t\022. \224\026\t\024\n\024\026 \033\n\t\023\031\n\033\031\032\026\ \203\025\n\021\021\020\004 \013\032\n\027\n\024\031\006\031\021\025\017 \ \t\n\t\024\026\027\025\023\026 6% \(23/383\) \027)Tj /Span<>> BDC ( )Tj EMC (\202\032\205\033\033\031 \t)Tj /Span<>> BDC ( )Tj EMC (\n\024\013\032\020\024\020\003 \027\031\030\031\021\025\031\003 )Tj 0.052 Tw T* (\032\026\021\020 \033\032\n\024\025\027 3,3% \(14/425\) \(\255\231 0,47;\ 95% \200\215 0,18\2261,26\). \224\026\t\024\n\024\026 \025\021\f\031\013\ \203\025\n\021\021\020\004 \n\t\023\n\204\021\031\021\025\017 \t\n\t\024\ \026\027\025\023\026 )Tj 0.055 Tw T* (3,3% \(14/425\) \027)Tj /Span<>> BDC ( )Tj EMC (\202\032\205\033\033\031 \t)Tj /Span<>> BDC ( )Tj EMC (\205\001\025\027\026\021\025\031\003 \033\032\n\024\025\027 1,8% \(7/383\ \) \027)Tj /Span<>> BDC ( )Tj EMC (\202\032\205\033\033\031 \t)Tj /Span<>> BDC ( )Tj EMC (\n\024\013\032\020\024\020\003 \027\031\030\031\021\025\031\003 \032\026\ \021\020 \(\255\231 1,66; )Tj 0.026 Tw T* [(95% )0.5(\200\215 )0.6(0,69\2264,00\). )0.6(\207\032\031\030\021\002\002 )0.6(\033\032\n\030\n\023\204\025\024\031\023\022\021\n\t\024\022 )0.7(\n\033\031\032\026\203\025\025 )0.6(\027)]TJ /Span<>> BDC ( )Tj EMC 25.741 0 Td [(\202\032\205\033\033\031 )0.6(\t)]TJ /Span<>> BDC ( )Tj EMC 3.655 0 Td [(\205\001\025\027\026\021\025\031\003 )0.5(\032\026\021\020 )0.6(\033\032\002\003\n\017 )0.6(\013\025\001\013\025 )0.6(\027\020\001\031 )]TJ 0.21 Tw -29.396 -1.111 Td (\021\026)Tj /Span<>> BDC ( )Tj EMC (7\2268)Tj /Span<>> BDC ( )Tj EMC (\003\025\021\205\024; 95% \200\215 \2502,21\22617,6. \207\032\031\030\021\ \002\002 \033\032\n\030\n\023\204\025\024\031\023\022\021\n\t\024\022 \033\ \032\031\005\020\027\026\021\025\002 \027)Tj /Span<>> BDC ( )Tj EMC (\t\024\026\203\025\n\021\026\032\031 \033\026\203\025\031\021\024\n\027 \ )Tj 0.023 Tw T* (\027)Tj /Span<>> BDC ( )Tj EMC (\202\032\205\033\033\031 \t)Tj /Span<>> BDC ( )Tj EMC (\205\001\025\027\026\021\025\031\003 \032\026\021\020 \033\032\002\003\n\ \017 \013\025\001\013\025 \205\027\031\023\025\006\025\027\026\023\026\t\ \022 \021\026)Tj /Span<>> BDC ( )Tj EMC (12 \006\026\t\n\027.)Tj 0.125 Tw 0 -1.111 TD [(\221\201\222\035\223\224\036\217\215\036: )0.6(\205\001\025\027\026\021\025\031 )0.5(\032\026\021\020 )0.5(\033\n\t\023\031 )0.6(\220\036\240 )0.5(\t\205\211\031\t\024\027\031\021\021\n )0.6(\021\031 )0.5(\205\027\031\023\025\006\025\027\026\031\024 )0.5(\033\032\n\030\n\023\204\025\024\031\023\022\021\n\t\024\022 )0.5(\n\033\031\032\026\203\025\025, )0.5(\021\031 )]TJ 0.271 Tw 0 -1.111 TD [(\033\032\025\027\n\030\025\024 )0.5(\013)]TJ /Span<>> BDC ( )Tj EMC 5.605 0 Td [(\t\024\026\024\025\t\024\025\006\031\t\013\025 )0.6(\030\n\t\024\n\027\031\032\021\n\003\205 )0.5(\t\021\025\204\031\021\025\007 )0.6(\013\026\013 )0.5(\006\026\t\024\n\024\020 )0.5(\013\032\n\027\n\024\031\006\031\021\025\017, )0.5(\033\n\t\023\031\n\033\031\032\026\203\025\n\021\021\020\004 )]TJ 0.023 Tw -5.605 -1.111 Td (\025)Tj /Span<>> BDC ( )Tj EMC (\025\021\f\031\013\203\025\n\021\021\020\004 \n\t\023\n\204\021\031\021\025\ \017 \033\n)Tj /Span<>> BDC ( )Tj EMC (\t\032\026\027\021\031\021\025\007 \t)Tj /Span<>> BDC ( )Tj EMC (\n\024\013\032\020\024\020\003 \027\031\030\031\021\025\031\003 \032\026\ \021\020 \033\032\002\003\n\017 \013\025\001\013\025.)Tj /T1_2 1 Tf 0.01 Tc 0.115 Tw 8 0 0 8 42.5596 393.3795 Tm [(\037\036\035\034\033\032\031\033)5( \030\036\027\032\026:)]TJ /T1_1 1 Tf 0 Tc 0.12 Tw 8.59 0 Td ( \032\026\021\026 \033\032\002\003\n\017 \013\025\001\013\025, \024\032\026\ \021\t\026\021\026\023\022\021\026\002 \r\021\030\n\003\025\013\032\n\004\ \025\032\205\032\202\025\002, \220\230\240, \n\024\013\032\020\024\n\031\ \027\031\030\031\021\025\031 \032\026\021\020 \033\032\002\003\n\017 \013\ \025\001\013\025, \205\001\025\027\026\021\025\031 )Tj 0.023 Tw -8.595 -1.2 Td (\032\026\021\020 \033\032\002\003\n\017 \013\025\001\013\025)Tj /T1_2 1 Tf 0.01 Tc 0.018 Tw 0.005 -1.909 Td [(\037\027\025\024\036\023\037\022)5( \023\025\022\033\021\033\030\027\032:)]TJ /T1_1 1 Tf 0 Tc 0.023 Tw 10.401 0 Td ( \201\027\024\n\032\020 \016\026\002\027\023\002\007\024 \n\005 \n\024\t\ \205\024\t\024\027\025\025 \013\n\021\f\023\025\013\024\026 \025\021\024\ \031\032\031\t\n\027)Tj /T1_2 1 Tf 0.01 Tc 0.018 Tw -10.401 -1.909 Td [(\023\030\022\027\034\025\023\037\023)4.9( \024\023\025\026\025\030\023\021\027\032\026\025\023\017)5( \027\022\030\211\022\030\022\032\211\035\022)]TJ 0.033 Tc -0.016 Tw 0 -2.617 TD [(\020\036\017)4.7( \016\023\022\023\021\027\032\026\025\023\017:)]TJ /T1_3 1 Tf 0.023 Tc -0.011 Tw 9.157 0 Td ( \221\017\027\017\006\t\027)Tj /Span<>> BDC ( )Tj EMC (\217.\025., \202\035\036\022\f\036\036\r)Tj /Span<>> BDC ( )Tj EMC (\204.\200., \223\036\030\027\t\001\024\r)Tj /Span<>> BDC ( )Tj EMC (\221.\200., \217\t\002\026\022\024\r)Tj /Span<>> BDC ( )Tj EMC [(\213.\206. \207\036\024\023\026\f\027\024 \035\017 \024\f\021\026\r\035\ \016\021\034 \030\026\027\031 \023\030\016\n\024\005 \022\017\001\022\017\ \023\024\f\035\036)23( )]TJ 0.011 Tc -0.035 Tw -9.162 -1.2 Td (\021\030\026\027\f\026\027\026\035\034\027\024\005 \220\027\007\024\n\017\ \022\030\024\b\017\030\031\030\020\017\017 \024\021\022\030\t\021\024\005\ ? \(\f\017\f\021\036\n\026\021\017\004\036\f\022\017\005 \024\002\024\030\ \017)Tj /Span<>> BDC ( )Tj EMC (\n\036\021\026\026\027\026\035\017\). )Tj /T1_1 1 Tf -0.011 Tw (\222\n\023\n\033\032\n\013\024\n\023\n\202\025\002.)Tj /T1_3 1 Tf -0.035 Tw ( 2024; \021.)Tj /Span<>> BDC ( )Tj EMC (23, \225)Tj /Span<>> BDC ( )Tj EMC (1, \f.)Tj /Span<>> BDC ( )Tj EMC [(181\226187.)11( )]TJ 0.023 Tc -0.023 Tw 0 -1.2 TD (https://doi.org/10.33878/2073-7556-2024-23-1-181-187)Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 0 Tc 0.023 Tw 18 0 0 18 75.9692 280.7639 Tm [(Is it safe to leav)12(e r)31.1(ectal w)11(ound opened af)-31(ter tr)21(ansanal )]TJ 0.013 -1.167 Td [(micr)20(osur)31.1(ger)-31(y? A s)10(y)10(stematic r)31(e)11(vie)11(w and meta-analy)10(sis.)]TJ 0 0 0 1 k /GS1 gs 0 Tw 14 0 0 14 42.5197 235.26 Tm [(Roman\022)-23.3(K.\022)-23.2(Sinits)10(yn)]TJ 8.162 0 0 8.162 142.416 239.922 Tm (1)Tj 0.023 Tw 14 0 0 14 147.052 235.26 Tm [(, Michael\022)-23.2(V)62(.\022)-23.3(Alek)11(see)11(v)]TJ -0.069 Tc 0.069 Tw 8.162 0 0 8.162 268.0784 239.922 Tm [(1,)-69(2)]TJ 0 Tc 0.023 Tw 14 0 0 14 279.399 235.26 Tm [(, Stanislav\022)-23.2(V)62(.\022)-23.3(Ch)11(erny)10.1(sh)11(ov)]TJ 0 Tw 8.162 0 0 8.162 420.9771 239.922 Tm (1)Tj 14 0 0 14 425.613 235.26 Tm (, )Tj -27.364 -1.143 Td [(Eugeny\022)-23.2(G.\022)-23.3(R)20(ybak)11(ov)]TJ 8.162 0 0 8.162 153.687 223.922 Tm (1)Tj 5.83 0 0 5.83 42.5197 204.9208 Tm (1)Tj 0.023 Tw 10 0 0 10 45.8311 201.5908 Tm [(R)20(y)21(zhikh National Medical Resear)31(ch Center of Colopr)20.1(octology \(Saly)21(ama Adily)21(a\022)-23.3(st., 2, Moscow)22(, 1)125(23)58(423, Russia\))]TJ 0 Tw ( )Tj 5.83 0 0 5.83 42.5197 192.9208 Tm (2)Tj 0.023 Tw 10 0 0 10 45.8311 189.5908 Tm [(Russian Medical Academ)21.1(y of Continuous Pr)20(ofessional Education \(Barrikadnay)21.1(a\022)-23.3(st., 2/1-1)69(, Moscow)22(, 1)125(2)23(5)23(99)35(3, )]TJ 0 Tw -0.331 -1.2 Td (Russia\))Tj /T1_1 1 Tf 0.089 Tw 9 0 0 9 90.7087 159.0869 Tm [(INTR)19(ODUCTION: there is no consensus on the need for closure of rectal w)12(ounds af)-46(ter transanal endomicrosurg)12(er)-43(y )]TJ 0.009 Tw 0 -1.111 TD [(\(TEM\). The results of studies on the treatment of patients using open \ and closed w)12(ound manag)12(ement are p)46(resented )]TJ 0.023 Tw T* (in this meta-analysis.)Tj T* [(AIM: to com)16(pare 2 methods of rectal w)12(ound manag)12(ement in patients af)-45.9(ter TEM.)]TJ 0.014 Tw T* [(MA)45(TERIAL)-27.9(S A)53(ND METHODS: a systematic revie)10(w and meta-analysis w)13(as per)-34(for)-14(med in accord)26(ance with P)66(RISMA guide)]TJ 0 Tw (-)Tj 0 -1.111 TD (lines.)Tj 0.058 Tw 0 -1.111 TD [(RESUL)30(T)-10(S: six studies w)12(ere selected for the per)-37(iod from 2002 to 2021. The meta-analysis included 808 patients: in )]TJ 0.091 Tw T* (383)Tj /Span<>> BDC ( )Tj EMC [(\(47%\) )0.5(patients the )0.5(rectal )0.5(w)12(ound w)13(as manag)12.1(ed openly)42(, )0.5(in 425)]TJ /Span<>> BDC ( )Tj EMC [(\(53%\) )0.5(patients it )0.5(w)13(as sutured. The incidence )]TJ ET 1 0.68 0 0.12 k /GS0 gs q 1 0 0 1 42.5197 577.1533 cm 0 0 m 0 0 l 0 -11.339 l 42.52 -11.339 l 42.52 0 l h f Q BT 0 0 0 0 k /T1_2 1 Tf 0 Tw 9 0 0 9 47.6607 568.226 Tm (\021\033\r\035\f\033)Tj ET 1 0.68 0 0.12 k q 1 0 0 1 42.5197 167.5913 cm 0 0 m 0 0 l 0 -11.339 l 42.52 -11.339 l 42.52 0 l h f Q BT 0 0 0 0 k /T1_2 1 Tf 9 0 0 9 45.2263 158.664 Tm (ABSTRACT)Tj 1 0.68 0 0.12 k /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\214)10(\211\036\033 \035\030\032\t\033)30(\b)42(\032)-21(\240\033\233)]TJ 57.136 0 Td (REVIEW)Tj /T1_4 1 Tf 25 0 0 25 504.6771 56.0378 Tm (181)Tj ET q 0 g 0 G 0 j 0 J /Fm1 Do Q 0 0 0 0 k 368.504 725.67 59.155 11.338 re f /PlacedPDF /MC0 BDC q 369.135 736.808 m 368.896 736.808 368.703 736.616 368.703 736.376 c 368.703 736.376 l 368.703 726.285 l 368.703 726.045 368.896 725.853 369.135 725.853 c 369.135 725.853 l 427.035 725.853 l 427.273 725.853 427.469 726.045 427.469 726.285 c 427.469 726.285 l 427.469 736.376 l 427.469 736.616 427.273 736.808 427.035 736.808 c 427.035 736.808 l h W n q 0 g -0.0000005 -10.9560913 -10.9560913 0.0000005 398.0855785 736.8086309 cm BX /Sh0 sh EX Q Q q 368.504 725.67 59.155 11.337 re W n 0 0 0 0.84 k q 1 0 0 1 385.2169 732.4249 cm 0 0 m -0.025 0.1 -0.063 0.196 -0.112 0.287 c -0.157 0.374 -0.218 0.451 -0.292 0.515 c -0.37 0.582 -0.46 0.632 -0.558 0.664 c -0.669 0.701 -0.786 0.719 -0.903 0.717 c -1.076 0.722 -1.247 0.681 -1.4 0.6 c -1.536 0.526 -1.652 0.42 -1.74 0.292 c -1.83 0.158 -1.895 0.008 -1.934 -0.149 c -2.018 -0.48 -2.018 -0.827 -1.934 -1.158 c -1.896 -1.316 -1.83 -1.466 -1.74 -1.602 c -1.653 -1.731 -1.536 -1.837 -1.4 -1.912 c -1.247 -1.993 -1.076 -2.033 -0.903 -2.029 c -0.774 -2.032 -0.647 -2.006 -0.528 -1.955 c -0.427 -1.906 -0.337 -1.837 -0.263 -1.753 c -0.185 -1.665 -0.124 -1.563 -0.082 -1.453 c -0.034 -1.338 0 -1.218 0.019 -1.094 c 0.635 -1.094 l 0.624 -1.297 0.578 -1.497 0.497 -1.684 c 0.421 -1.857 0.312 -2.015 0.175 -2.146 c 0.039 -2.277 -0.123 -2.379 -0.3 -2.446 c -0.492 -2.519 -0.695 -2.555 -0.9 -2.552 c -1.15 -2.557 -1.397 -2.506 -1.625 -2.404 c -1.829 -2.307 -2.01 -2.169 -2.157 -1.997 c -2.308 -1.821 -2.423 -1.617 -2.497 -1.397 c -2.655 -0.924 -2.655 -0.412 -2.497 0.061 c -2.423 0.281 -2.307 0.485 -2.157 0.661 c -2.01 0.833 -1.829 0.973 -1.625 1.07 c -1.398 1.174 -1.15 1.226 -0.9 1.222 c -0.707 1.223 -0.515 1.196 -0.329 1.14 c -0.159 1.088 0.001 1.006 0.144 0.898 c 0.278 0.793 0.39 0.662 0.473 0.513 c 0.562 0.349 0.615 0.167 0.629 -0.019 c 0 -0.019 l 0 0 l f Q q 1 0 0 1 386.3458 733.5723 cm 0 0 m 0.584 0 l 0.584 -1.328 l 0.662 -1.204 0.771 -1.103 0.9 -1.033 c 1.046 -0.951 1.213 -0.91 1.381 -0.914 c 1.627 -0.9 1.869 -0.979 2.058 -1.137 c 2.234 -1.312 2.325 -1.556 2.305 -1.803 c 2.305 -3.596 l 1.716 -3.596 l 1.716 -1.976 l 1.724 -1.817 1.678 -1.66 1.585 -1.53 c 1.486 -1.43 1.347 -1.379 1.206 -1.392 c 1.114 -1.39 1.024 -1.408 0.94 -1.445 c 0.865 -1.479 0.798 -1.529 0.744 -1.591 c 0.687 -1.656 0.645 -1.73 0.616 -1.812 c 0.586 -1.896 0.571 -1.986 0.571 -2.077 c 0.571 -3.615 l 0 -3.615 l 0 0 l f Q q 1 0 0 1 389.692 731.1235 cm 0 0 m 0 -0.099 0.014 -0.198 0.043 -0.292 c 0.069 -0.382 0.112 -0.466 0.17 -0.54 c 0.229 -0.611 0.304 -0.669 0.388 -0.709 c 0.486 -0.754 0.594 -0.776 0.702 -0.773 c 0.845 -0.78 0.987 -0.742 1.108 -0.664 c 1.217 -0.582 1.296 -0.468 1.336 -0.337 c 1.881 -0.337 l 1.827 -0.603 1.675 -0.838 1.456 -0.996 c 1.35 -1.073 1.231 -1.131 1.105 -1.169 c 0.971 -1.208 0.831 -1.229 0.691 -1.227 c 0.509 -1.227 0.328 -1.191 0.16 -1.121 c 0.007 -1.063 -0.13 -0.972 -0.244 -0.855 c -0.356 -0.73 -0.44 -0.583 -0.491 -0.422 c -0.548 -0.243 -0.576 -0.056 -0.574 0.133 c -0.575 0.313 -0.545 0.493 -0.486 0.664 c -0.426 0.826 -0.335 0.974 -0.22 1.102 c 0.004 1.375 0.338 1.534 0.691 1.535 c 0.883 1.539 1.072 1.495 1.243 1.408 c 1.402 1.326 1.541 1.209 1.649 1.067 c 1.759 0.922 1.838 0.757 1.883 0.582 c 1.932 0.396 1.945 0.203 1.92 0.013 c 0 0.013 l 0 0 l 1.342 0.377 m 1.335 0.468 1.315 0.557 1.283 0.643 c 1.253 0.724 1.209 0.798 1.153 0.863 c 1.097 0.922 1.03 0.97 0.957 1.004 c 0.874 1.043 0.783 1.063 0.691 1.062 c 0.6 1.062 0.509 1.044 0.425 1.009 c 0.345 0.976 0.273 0.926 0.213 0.863 c 0.153 0.799 0.105 0.724 0.072 0.643 c 0.037 0.559 0.017 0.468 0.014 0.377 c 1.355 0.377 l h f Q q 1 0 0 1 393.8116 731.7051 cm 0 0 m -0.012 0.144 -0.082 0.276 -0.194 0.366 c -0.31 0.452 -0.451 0.495 -0.595 0.489 c -0.675 0.488 -0.755 0.476 -0.831 0.452 c -0.918 0.424 -0.998 0.375 -1.062 0.311 c -1.142 0.229 -1.202 0.131 -1.24 0.024 c -1.29 -0.132 -1.312 -0.296 -1.304 -0.459 c -1.304 -0.569 -1.292 -0.677 -1.267 -0.784 c -1.244 -0.885 -1.202 -0.983 -1.145 -1.07 c -1.09 -1.154 -1.016 -1.224 -0.93 -1.275 c -0.833 -1.33 -0.722 -1.356 -0.611 -1.352 c -0.457 -1.357 -0.307 -1.301 -0.194 -1.195 c -0.078 -1.077 -0.005 -0.922 0.011 -0.757 c 0.587 -0.757 l 0.556 -1.055 0.419 -1.332 0.202 -1.538 c -0.022 -1.721 -0.306 -1.815 -0.595 -1.803 c -0.777 -1.806 -0.958 -1.771 -1.126 -1.7 c -1.293 -1.642 -1.445 -1.547 -1.57 -1.421 c -1.68 -1.297 -1.763 -1.151 -1.814 -0.993 c -1.87 -0.822 -1.898 -0.643 -1.896 -0.462 c -1.898 -0.276 -1.871 -0.091 -1.817 0.087 c -1.766 0.252 -1.682 0.405 -1.57 0.537 c -1.459 0.664 -1.323 0.766 -1.168 0.834 c -0.991 0.914 -0.798 0.955 -0.603 0.954 c -0.457 0.954 -0.311 0.935 -0.17 0.895 c -0.039 0.858 0.084 0.799 0.194 0.72 c 0.302 0.643 0.393 0.543 0.459 0.428 c 0.531 0.298 0.572 0.155 0.582 0.008 c 0 0.008 l 0 0 l f Q q 1 0 0 1 394.8712 733.5723 cm 0 0 m 0.577 0 l 0.577 -2.048 l 1.615 -0.985 l 2.322 -0.985 l 1.323 -1.944 l 2.417 -3.604 l 1.716 -3.604 l 0.919 -2.337 l 0.577 -2.669 l 0.577 -3.604 l 0 -3.604 l h f Q q 1 0 0 1 398.712 732.5762 cm 0 0 m 0.436 0 l 0.436 0.218 l 0.429 0.352 0.448 0.486 0.488 0.614 c 0.521 0.705 0.577 0.786 0.651 0.85 c 0.717 0.905 0.795 0.943 0.879 0.961 c 0.966 0.979 1.056 0.988 1.145 0.988 c 1.28 0.993 1.416 0.981 1.548 0.954 c 1.548 0.505 l 1.509 0.516 1.469 0.523 1.429 0.528 c 1.379 0.532 1.33 0.532 1.28 0.528 c 1.209 0.53 1.14 0.511 1.081 0.473 c 1.019 0.419 0.987 0.337 0.999 0.255 c 0.999 -0.011 l 1.498 -0.011 l 1.498 -0.441 l 1.009 -0.441 l 1.009 -2.622 l 0.436 -2.622 l 0.436 -0.428 l 0.005 -0.428 l 0.005 0 l 0 0 l f Q q 1 0 0 1 401.7535 729.8965 cm 0 0 m -0.191 -0.003 -0.381 0.032 -0.559 0.104 c -0.715 0.167 -0.856 0.264 -0.972 0.388 c -1.091 0.512 -1.181 0.659 -1.238 0.82 c -1.356 1.18 -1.356 1.567 -1.238 1.925 c -1.181 2.087 -1.091 2.234 -0.972 2.358 c -0.856 2.481 -0.715 2.578 -0.559 2.643 c -0.199 2.78 0.198 2.78 0.558 2.643 c 0.714 2.578 0.855 2.481 0.972 2.358 c 1.09 2.234 1.181 2.087 1.237 1.925 c 1.355 1.567 1.355 1.18 1.237 0.82 c 1.181 0.659 1.09 0.512 0.972 0.388 c 0.855 0.266 0.713 0.169 0.558 0.106 c 0.38 0.034 0.191 -0.002 0 0 c 0 0.454 m 0.115 0.451 0.23 0.479 0.332 0.534 c 0.424 0.586 0.502 0.659 0.562 0.746 c 0.624 0.836 0.669 0.936 0.695 1.041 c 0.752 1.26 0.752 1.491 0.695 1.71 c 0.669 1.816 0.625 1.916 0.562 2.005 c 0.502 2.091 0.423 2.163 0.332 2.215 c 0.123 2.323 -0.126 2.323 -0.335 2.215 c -0.427 2.163 -0.505 2.091 -0.566 2.005 c -0.628 1.916 -0.673 1.816 -0.699 1.71 c -0.756 1.491 -0.756 1.26 -0.699 1.041 c -0.672 0.936 -0.627 0.836 -0.566 0.746 c -0.506 0.659 -0.427 0.586 -0.335 0.534 c -0.232 0.478 -0.117 0.451 0 0.454 c f Q q 1 0 0 1 403.5515 732.5762 cm 0 0 m 0.531 0 l 0.531 -0.505 l 0.55 -0.43 0.583 -0.359 0.629 -0.297 c 0.681 -0.229 0.74 -0.167 0.807 -0.114 c 0.877 -0.059 0.956 -0.014 1.039 0.019 c 1.123 0.053 1.213 0.07 1.304 0.069 c 1.52 0.069 l 1.52 -0.486 l 1.395 -0.467 l 1.269 -0.467 l 1.178 -0.468 1.087 -0.488 1.004 -0.526 c 0.917 -0.565 0.839 -0.625 0.778 -0.699 c 0.716 -0.783 0.669 -0.878 0.643 -0.98 c 0.604 -1.104 0.584 -1.233 0.586 -1.362 c 0.586 -2.603 l 0.01 -2.603 l 0.01 0 l 0 0 l f Q q 1 0 0 1 409.0202 729.9683 cm 0 0 m -0.577 0 l -0.577 0.364 l -0.649 0.23 -0.759 0.121 -0.893 0.047 c -1.022 -0.029 -1.169 -0.07 -1.32 -0.072 c -1.595 -0.095 -1.866 0.002 -2.064 0.194 c -2.234 0.413 -2.316 0.687 -2.295 0.964 c -2.295 2.608 l -1.719 2.608 l -1.719 1.014 l -1.735 0.843 -1.689 0.67 -1.588 0.531 c -1.492 0.433 -1.357 0.382 -1.219 0.39 c -1.116 0.387 -1.012 0.406 -0.917 0.446 c -0.84 0.479 -0.772 0.531 -0.72 0.595 c -0.667 0.661 -0.63 0.738 -0.611 0.82 c -0.588 0.911 -0.577 1.003 -0.577 1.097 c -0.577 2.611 l 0 2.611 l 0 0 l f Q q 1 0 0 1 409.6413 732.5762 cm 0 0 m 0.545 0 l 0.545 -0.353 l 0.617 -0.209 0.736 -0.094 0.882 -0.026 c 1.03 0.04 1.19 0.073 1.352 0.072 c 1.535 0.075 1.717 0.038 1.883 -0.037 c 2.031 -0.106 2.161 -0.208 2.263 -0.334 c 2.366 -0.465 2.442 -0.615 2.489 -0.775 c 2.54 -0.948 2.566 -1.127 2.566 -1.307 c 2.566 -1.479 2.542 -1.651 2.497 -1.817 c 2.455 -1.973 2.385 -2.121 2.29 -2.252 c 2.099 -2.522 1.789 -2.682 1.458 -2.68 c 1.369 -2.681 1.28 -2.674 1.193 -2.659 c 1.11 -2.644 1.028 -2.618 0.951 -2.584 c 0.875 -2.552 0.802 -2.509 0.736 -2.457 c 0.671 -2.406 0.615 -2.343 0.571 -2.273 c 0.571 -3.575 l -0.005 -3.575 l -0.005 0 l 0 0 l 2.008 -1.307 m 2.008 -1.191 1.993 -1.076 1.963 -0.964 c 1.936 -0.859 1.89 -0.759 1.828 -0.669 c 1.768 -0.584 1.69 -0.514 1.599 -0.462 c 1.503 -0.409 1.395 -0.382 1.286 -0.385 c 1.072 -0.372 0.867 -0.467 0.738 -0.638 c 0.607 -0.836 0.543 -1.072 0.555 -1.31 c 0.554 -1.433 0.57 -1.557 0.603 -1.676 c 0.631 -1.781 0.68 -1.879 0.747 -1.965 c 0.809 -2.044 0.886 -2.109 0.975 -2.157 c 1.071 -2.206 1.178 -2.23 1.286 -2.229 c 1.401 -2.232 1.517 -2.205 1.618 -2.148 c 1.708 -2.096 1.785 -2.025 1.843 -1.939 c 1.903 -1.85 1.945 -1.751 1.968 -1.646 c 1.995 -1.535 2.008 -1.421 2.008 -1.307 c f Q q 1 0 0 1 415.1662 729.9683 cm 0 0 m -0.545 0 l -0.545 0.353 l -0.616 0.211 -0.734 0.099 -0.879 0.034 c -1.027 -0.031 -1.187 -0.065 -1.349 -0.064 c -1.532 -0.067 -1.714 -0.03 -1.88 0.045 c -2.028 0.113 -2.158 0.214 -2.26 0.34 c -2.364 0.47 -2.441 0.62 -2.486 0.781 c -2.538 0.958 -2.564 1.143 -2.563 1.328 c -2.568 1.536 -2.536 1.742 -2.468 1.938 c -2.41 2.097 -2.319 2.242 -2.202 2.364 c -2.101 2.471 -1.977 2.555 -1.838 2.608 c -1.705 2.659 -1.563 2.685 -1.421 2.685 c -1.338 2.685 -1.256 2.678 -1.174 2.664 c -1.091 2.648 -1.01 2.624 -0.932 2.589 c -0.855 2.556 -0.783 2.514 -0.717 2.462 c -0.652 2.411 -0.597 2.349 -0.553 2.279 c -0.553 3.606 l 0.024 3.606 l 0.024 0 l 0 0 l -2.008 1.277 m -2.009 1.166 -1.994 1.056 -1.965 0.948 c -1.939 0.845 -1.896 0.748 -1.835 0.661 c -1.777 0.578 -1.699 0.508 -1.61 0.459 c -1.404 0.355 -1.162 0.355 -0.956 0.459 c -0.866 0.512 -0.789 0.585 -0.73 0.671 c -0.671 0.762 -0.626 0.862 -0.6 0.966 c -0.572 1.076 -0.558 1.188 -0.558 1.301 c -0.543 1.542 -0.612 1.781 -0.751 1.979 c -0.88 2.14 -1.078 2.229 -1.283 2.22 c -1.402 2.224 -1.52 2.196 -1.623 2.138 c -1.714 2.083 -1.793 2.009 -1.852 1.92 c -1.911 1.828 -1.954 1.725 -1.977 1.617 c -1.999 1.505 -2.01 1.392 -2.008 1.277 c f Q q 1 0 0 1 417.9787 730.5499 cm 0 0 m -0.004 -0.052 0.005 -0.104 0.026 -0.151 c 0.052 -0.185 0.094 -0.202 0.136 -0.197 c 0.197 -0.197 l 0.223 -0.2 0.25 -0.2 0.276 -0.197 c 0.276 -0.595 l 0.199 -0.619 l 0.101 -0.64 l 0 -0.656 l -0.085 -0.656 l -0.187 -0.66 -0.288 -0.635 -0.377 -0.584 c -0.461 -0.528 -0.516 -0.437 -0.528 -0.337 c -0.648 -0.451 -0.792 -0.534 -0.951 -0.579 c -1.106 -0.628 -1.269 -0.654 -1.432 -0.656 c -1.546 -0.657 -1.659 -0.641 -1.769 -0.608 c -1.872 -0.579 -1.967 -0.531 -2.053 -0.468 c -2.136 -0.405 -2.203 -0.324 -2.25 -0.231 c -2.3 -0.127 -2.326 -0.012 -2.324 0.104 c -2.33 0.24 -2.299 0.375 -2.236 0.497 c -2.181 0.594 -2.101 0.675 -2.005 0.733 c -1.905 0.791 -1.795 0.833 -1.681 0.855 c -1.562 0.88 -1.442 0.899 -1.32 0.914 c -1.222 0.933 -1.123 0.947 -1.022 0.956 c -0.938 0.963 -0.855 0.977 -0.773 0.999 c -0.708 1.014 -0.649 1.046 -0.6 1.092 c -0.556 1.144 -0.533 1.211 -0.536 1.28 c -0.534 1.344 -0.553 1.408 -0.59 1.46 c -0.624 1.507 -0.668 1.544 -0.72 1.569 c -0.775 1.596 -0.834 1.613 -0.895 1.62 c -0.955 1.624 -1.016 1.624 -1.076 1.62 c -1.215 1.625 -1.354 1.591 -1.474 1.519 c -1.581 1.45 -1.647 1.333 -1.652 1.206 c -2.231 1.206 l -2.227 1.354 -2.185 1.498 -2.108 1.625 c -2.041 1.733 -1.951 1.824 -1.843 1.891 c -1.729 1.96 -1.603 2.007 -1.472 2.032 c -1.329 2.072 -1.183 2.098 -1.036 2.109 c -0.908 2.109 -0.781 2.096 -0.656 2.069 c -0.538 2.044 -0.425 2 -0.321 1.939 c -0.225 1.88 -0.143 1.8 -0.083 1.705 c -0.02 1.599 0.012 1.478 0.008 1.354 c 0.008 0.013 l 0 0 l -0.576 0.728 m -0.674 0.667 -0.785 0.631 -0.9 0.624 c -1.028 0.612 -1.155 0.594 -1.283 0.571 c -1.343 0.561 -1.402 0.547 -1.46 0.528 c -1.515 0.511 -1.566 0.485 -1.612 0.451 c -1.657 0.419 -1.692 0.376 -1.716 0.327 c -1.742 0.267 -1.755 0.203 -1.753 0.138 c -1.755 0.079 -1.735 0.021 -1.697 -0.024 c -1.661 -0.067 -1.615 -0.103 -1.564 -0.127 c -1.509 -0.154 -1.451 -0.171 -1.392 -0.181 c -1.335 -0.19 -1.278 -0.196 -1.222 -0.197 c -1.152 -0.196 -1.083 -0.188 -1.015 -0.173 c -0.94 -0.156 -0.87 -0.127 -0.805 -0.088 c -0.74 -0.048 -0.684 0.004 -0.64 0.066 c -0.594 0.134 -0.571 0.215 -0.574 0.297 c -0.574 0.725 l h f Q q 1 0 0 1 418.3371 732.5762 cm 0 0 m 0.434 0 l 0.434 0.784 l 0.996 0.784 l 0.996 0 l 1.527 0 l 1.527 -0.43 l 0.996 -0.43 l 0.996 -1.822 l 0.993 -1.874 0.993 -1.927 0.996 -1.979 c 1 -2.018 1.011 -2.056 1.031 -2.09 c 1.05 -2.122 1.079 -2.146 1.113 -2.159 c 1.162 -2.177 1.213 -2.185 1.265 -2.183 c 1.387 -2.183 l 1.428 -2.181 1.469 -2.175 1.509 -2.165 c 1.509 -2.608 l 1.323 -2.629 l 1.261 -2.633 1.199 -2.633 1.137 -2.629 c 1.013 -2.633 0.89 -2.619 0.771 -2.587 c 0.688 -2.564 0.613 -2.52 0.553 -2.459 c 0.499 -2.4 0.462 -2.328 0.446 -2.25 c 0.427 -2.155 0.416 -2.059 0.415 -1.963 c 0.415 -0.428 l -0.019 -0.428 l -0.019 0 l 0 0 l f Q q 1 0 0 1 420.7277 731.1235 cm 0 0 m 0 -0.099 0.014 -0.198 0.042 -0.292 c 0.068 -0.382 0.112 -0.466 0.17 -0.54 c 0.229 -0.611 0.303 -0.669 0.388 -0.709 c 0.486 -0.754 0.593 -0.776 0.701 -0.773 c 0.845 -0.78 0.987 -0.742 1.107 -0.664 c 1.216 -0.582 1.296 -0.468 1.336 -0.337 c 1.88 -0.337 l 1.827 -0.603 1.674 -0.838 1.456 -0.996 c 1.349 -1.073 1.231 -1.131 1.105 -1.169 c 0.973 -1.208 0.836 -1.228 0.699 -1.227 c 0.512 -1.23 0.327 -1.196 0.154 -1.126 c 0.003 -1.066 -0.133 -0.973 -0.244 -0.855 c -0.356 -0.73 -0.44 -0.583 -0.491 -0.422 c -0.548 -0.243 -0.576 -0.056 -0.574 0.133 c -0.575 0.313 -0.546 0.493 -0.486 0.664 c -0.426 0.826 -0.336 0.974 -0.221 1.102 c 0.002 1.374 0.334 1.532 0.685 1.535 c 0.877 1.539 1.067 1.495 1.238 1.408 c 1.396 1.326 1.535 1.209 1.644 1.067 c 1.753 0.922 1.833 0.757 1.878 0.582 c 1.927 0.396 1.939 0.203 1.915 0.013 c -0.002 0.013 l 0 0 l 1.341 0.377 m 1.335 0.468 1.315 0.557 1.283 0.643 c 1.253 0.724 1.209 0.798 1.153 0.863 c 1.096 0.926 1.027 0.978 0.951 1.014 c 0.868 1.054 0.777 1.074 0.685 1.073 c 0.594 1.073 0.504 1.055 0.419 1.02 c 0.339 0.986 0.267 0.937 0.207 0.874 c 0.147 0.81 0.099 0.735 0.066 0.653 c 0.031 0.569 0.011 0.479 0.008 0.388 c 1.349 0.388 l h f Q q 1 0 0 1 423.5192 730.7994 cm 0 0 m 0.002 -0.142 0.073 -0.274 0.191 -0.353 c 0.312 -0.423 0.45 -0.458 0.59 -0.454 c 0.651 -0.458 0.711 -0.458 0.773 -0.454 c 0.839 -0.447 0.904 -0.43 0.967 -0.406 c 1.024 -0.385 1.075 -0.349 1.116 -0.303 c 1.155 -0.252 1.174 -0.189 1.168 -0.125 c 1.166 -0.057 1.138 0.008 1.089 0.056 c 1.033 0.107 0.967 0.146 0.895 0.17 c 0.809 0.201 0.72 0.226 0.629 0.245 c 0.329 0.33 l 0.224 0.352 0.121 0.38 0.019 0.415 c -0.076 0.446 -0.166 0.491 -0.247 0.55 c -0.327 0.608 -0.391 0.683 -0.436 0.771 c -0.486 0.873 -0.511 0.986 -0.507 1.1 c -0.512 1.226 -0.475 1.351 -0.404 1.456 c -0.333 1.551 -0.243 1.63 -0.138 1.687 c -0.028 1.747 0.092 1.788 0.215 1.809 c 0.337 1.832 0.462 1.843 0.587 1.843 c 0.716 1.844 0.845 1.83 0.972 1.801 c 1.09 1.774 1.202 1.727 1.304 1.663 c 1.404 1.598 1.488 1.513 1.551 1.413 c 1.621 1.3 1.663 1.173 1.676 1.041 c 1.076 1.041 l 1.059 1.155 0.989 1.253 0.887 1.307 c 0.78 1.355 0.665 1.38 0.547 1.378 c 0.5 1.381 0.452 1.381 0.403 1.378 c 0.35 1.373 0.298 1.36 0.247 1.341 c 0.2 1.325 0.157 1.297 0.122 1.262 c 0.087 1.224 0.069 1.174 0.071 1.124 c 0.069 1.058 0.096 0.995 0.146 0.951 c 0.202 0.903 0.267 0.866 0.337 0.842 c 0.424 0.811 0.512 0.786 0.603 0.768 c 0.917 0.701 l 1.021 0.678 1.124 0.65 1.224 0.616 c 1.319 0.584 1.409 0.539 1.49 0.481 c 1.662 0.359 1.762 0.16 1.755 -0.05 c 1.76 -0.189 1.723 -0.326 1.649 -0.443 c 1.582 -0.551 1.491 -0.642 1.384 -0.709 c 1.267 -0.778 1.14 -0.827 1.007 -0.855 c 0.873 -0.885 0.735 -0.9 0.598 -0.9 c 0.443 -0.902 0.29 -0.883 0.141 -0.845 c 0.01 -0.812 -0.114 -0.753 -0.223 -0.674 c -0.324 -0.601 -0.407 -0.504 -0.465 -0.393 c -0.527 -0.269 -0.559 -0.131 -0.558 0.008 c 0.019 0.008 l 0 0 l f Q 0.146 0.941 0.992 0.044 k q 1 0 0 1 372.9062 729.3892 cm 0 0 m 3.612 2.406 l 3.612 5.296 l 0 5.296 l h f Q 0 0.889 0.676 0 k q 1 0 0 1 376.5186 729.3892 cm 0 0 m -3.612 2.406 l -3.612 5.296 l 0 5.296 l h f Q 0.694 0.076 0.209 0 k q 1 0 0 1 374.7125 735.3145 cm 0 0 m -2.2 0 -3.984 -1.784 -3.984 -3.984 c -3.984 -6.184 -2.2 -7.968 0 -7.968 c 2.2 -7.968 3.984 -6.184 3.984 -3.984 c 3.984 -1.784 2.2 0 0 0 c 0 -6.993 m -1.662 -6.993 -3.009 -5.646 -3.009 -3.984 c -3.009 -2.322 -1.662 -0.975 0 -0.975 c 1.662 -0.975 3.009 -2.322 3.009 -3.984 c 3.009 -5.646 1.662 -6.993 0 -6.993 c f Q 0 0.235 0.86 0 k q 1 0 0 1 376.9137 729.2803 cm 0 0 m -1.118 -1.208 -3.015 -1.281 -4.237 -0.159 c -5.159 0.688 -5.459 2.005 -4.999 3.156 c -5.833 3.687 l -6.736 1.681 -5.843 -0.679 -3.836 -1.582 c -2.218 -2.311 -0.312 -1.881 0.836 -0.528 c 0 0 l f Q 0 0 0 0.6 k q 1 0 0 1 369.1348 736.8087 cm 0 0 m -0.238 0 -0.432 -0.193 -0.432 -0.432 c -0.432 -10.524 l -0.432 -10.763 -0.238 -10.956 0 -10.956 c 57.901 -10.956 l 58.139 -10.956 58.333 -10.763 58.333 -10.524 c 58.333 -0.432 l 58.333 -0.193 58.139 0 57.901 0 c h 57.901 -11.155 m 0 -11.155 l -0.348 -11.155 -0.631 -10.872 -0.631 -10.524 c -0.631 -0.432 l -0.631 -0.084 -0.348 0.199 0 0.199 c 57.901 0.199 l 58.249 0.199 58.532 -0.084 58.532 -0.432 c 58.532 -10.524 l 58.532 -10.872 58.249 -11.155 57.901 -11.155 c f Q EMC Q endstream endobj 102 0 obj <>/Properties<>>>/Subtype/Form>>stream 0 0 0 0 k /GS0 gs 435.72 725.668 60.343 11.34 re f /PlacedPDF /MC0 BDC 0 0 0 1 k 435.734 725.682 60.328 11.326 re 435.734 737.008 m 436.506 736.222 58.771 -9.769 re f q 435.72 725.668 60.343 11.34 re W n q 1 0 0 1 452.391 735.5594 cm 0 0 m 0.962 -1.226 1.608 -2.673 1.608 -4.222 c 1.608 -5.781 0.951 -7.212 -0.023 -8.443 c 42.162 -8.443 l 42.162 0 l 0 0 l f Q 0 0 0 0.4 k q 1 0 0 1 439.4632 731.347 cm 0 0 m 0 1.495 0.569 2.789 1.707 3.882 c 1.83 4 1.957 4.108 2.086 4.212 c -2.233 4.212 l -2.233 -4.231 l 2.141 -4.231 l 1.992 -4.114 1.848 -3.989 1.707 -3.855 c 0.569 -2.78 0 -1.495 0 0 c f Q 0 0 0 1 k q 1 0 0 1 445.777 732.5765 cm 0 0 m 0.317 0.306 0.72 0.458 1.21 0.458 c 1.921 0.458 2.431 0.193 2.738 -0.337 c 1.958 -0.707 l 1.813 -0.409 1.602 -0.26 1.322 -0.26 c 0.802 -0.26 0.542 -0.584 0.542 -1.233 c 0.542 -1.882 0.802 -2.207 1.322 -2.207 c 1.659 -2.207 1.896 -2.048 2.03 -1.732 c 2.753 -2.088 l 2.417 -2.653 1.912 -2.937 1.239 -2.937 c 0.72 -2.937 0.305 -2.786 -0.008 -2.485 c -0.32 -2.184 -0.476 -1.768 -0.476 -1.239 c -0.476 -0.719 -0.317 -0.306 0 0 c f Q q 1 0 0 1 445.1751 732.2396 cm 0 0 m -0.765 -0.37 l -0.909 -0.072 -1.125 0.077 -1.414 0.077 c -1.924 0.077 -2.179 -0.248 -2.179 -0.896 c -2.179 -1.545 -1.924 -1.87 -1.414 -1.87 c -1.077 -1.87 -0.837 -1.711 -0.692 -1.395 c 0.014 -1.751 l -0.323 -2.316 -0.828 -2.6 -1.502 -2.6 c -2.021 -2.6 -2.438 -2.449 -2.75 -2.148 c -3.064 -1.847 -3.22 -1.431 -3.22 -0.902 c -3.22 -0.382 -3.059 0.031 -2.736 0.337 c -2.414 0.643 -2.012 0.795 -1.531 0.795 c -0.818 0.795 -0.308 0.53 0 0 c f Q q 1 0 0 1 449.34 735.2288 cm 0 0 m -0.125 0.118 -0.253 0.226 -0.383 0.331 c -1.737 0.331 l -0.144 -0.47 0.942 -2.052 0.943 -3.876 c 0.943 -3.882 l 0.945 -5.723 -0.161 -7.318 -1.777 -8.113 c -0.43 -8.113 l -0.273 -7.992 -0.121 -7.863 0.029 -7.723 c 1.128 -6.694 1.677 -5.413 1.677 -3.882 c 1.677 -2.351 1.118 -1.057 0 0 c f Q q 1 0 0 1 440.1975 731.3411 cm 0 0 m 0 0.006 l -0.001 1.832 1.085 3.417 2.681 4.218 c 1.352 4.218 l 1.223 4.114 1.095 4.005 0.972 3.888 c -0.166 2.794 -0.734 1.5 -0.734 0.006 c -0.734 -1.489 -0.166 -2.774 0.972 -3.849 c 1.113 -3.983 1.258 -4.108 1.406 -4.225 c 2.72 -4.225 l 1.105 -3.431 0.001 -1.839 0 0 c f Q 0 0 0 0.4 k q 1 0 0 1 452.391 735.5594 cm 0 0 m -3.435 0 l -3.305 -0.104 -3.176 -0.213 -3.052 -0.33 c -1.934 -1.387 -1.375 -2.682 -1.375 -4.212 c -1.375 -5.744 -1.924 -7.023 -3.023 -8.054 c -3.172 -8.193 -3.325 -8.322 -3.481 -8.443 c -0.023 -8.443 l 0.951 -7.212 1.608 -5.781 1.608 -4.222 c 1.608 -2.673 0.962 -1.226 0 0 c f Q 0 0 0 0 k q 1 0 0 1 459.452 733.4471 cm 0 0 m 1.271 0 l 2.298 -1.508 l 3.324 0 l 4.599 0 l 2.881 -2.45 l 2.881 -4.232 l 1.718 -4.232 l 1.718 -2.45 l 0 0 l -0.685 -1.967 m -0.436 -2.035 -0.241 -2.161 -0.104 -2.344 c 0.032 -2.528 0.101 -2.752 0.101 -3.02 c 0.101 -3.427 -0.047 -3.731 -0.341 -3.932 c -0.634 -4.133 -1.081 -4.232 -1.682 -4.232 c -3.611 -4.232 l -3.611 0 l -1.865 0 l -1.239 0 -0.786 -0.088 -0.506 -0.267 c -0.225 -0.443 -0.084 -0.729 -0.084 -1.119 c -0.084 -1.326 -0.135 -1.501 -0.237 -1.647 c -0.341 -1.791 -0.489 -1.898 -0.685 -1.967 c -1.766 -3.49 m -1.532 -3.49 -1.357 -3.443 -1.24 -3.351 c -1.121 -3.259 -1.062 -3.119 -1.062 -2.931 c -1.062 -2.748 -1.121 -2.61 -1.237 -2.521 c -1.354 -2.428 -1.53 -2.381 -1.766 -2.381 c -2.449 -2.381 l -2.449 -3.49 l -1.766 -3.49 l -1.806 -1.639 m -1.622 -1.639 -1.482 -1.601 -1.389 -1.525 c -1.294 -1.45 -1.246 -1.338 -1.246 -1.19 c -1.246 -1.045 -1.294 -0.934 -1.389 -0.858 c -1.482 -0.781 -1.622 -0.742 -1.806 -0.742 c -2.449 -0.742 l -2.449 -1.639 l -1.806 -1.639 l f Q q 1 0 0 1 469.006 730.9329 cm 0 0 m 0 0.951 l 0 1.209 0.014 1.473 0.033 1.751 c 0.007 1.751 l -0.132 1.473 -0.244 1.222 -0.39 0.951 c -0.965 0.013 l -0.965 0 l h 0 -1.777 m 0 -0.753 l -1.902 -0.753 l -1.902 -0.099 l -0.277 2.517 l 0.951 2.517 l 0.951 0 l 1.467 0 l 1.467 -0.753 l 0.951 -0.753 l 0.951 -1.777 l 0 -1.777 l f Q q 1 0 0 1 470.947 729.6907 cm 0 0 m 0 0.357 0.245 0.614 0.595 0.614 c 0.945 0.614 1.183 0.363 1.183 0 c 1.183 -0.35 0.945 -0.608 0.588 -0.608 c 0.245 -0.608 0 -0.35 0 0 c f Q q 1 0 0 1 473.557 731.2963 cm 0 0 m -0.007 -0.984 0.229 -1.454 0.621 -1.454 c 1.011 -1.454 1.222 -0.964 1.222 0.013 c 1.222 0.965 1.018 1.467 0.614 1.467 c 0.244 1.467 -0.007 0.998 0 0 c 2.227 0.026 m 2.227 -1.302 1.69 -2.213 0.595 -2.213 c -0.517 -2.213 -1.005 -1.216 -1.012 0 c -1.012 1.242 -0.482 2.227 0.627 2.227 c 1.777 2.227 2.227 1.203 2.227 0.026 c f Q EMC Q endstream endobj 213 0 obj <> endobj 214 0 obj <>stream Adobe Graphics Manager 2021-04-12T11:52:16+05:00 2021-04-12T11:52:16+05:00 Acrobat Distiller 10.1.16 (Windows) CCBYv40_logo.ai densen endstream endobj 100 0 obj <> endobj 91 0 obj [/DeviceN[/Black]/DeviceCMYK 216 0 R 217 0 R] endobj 215 0 obj <> endobj 218 0 obj <> endobj 216 0 obj <>stream {1.000000 2 1 roll 1.000000 2 1 roll 1.000000 2 1 roll 0 index 1.000000 cvr exch sub 2 1 roll 5 -1 roll 1.000000 cvr exch sub 5 1 roll 4 -1 roll 1.000000 cvr exch sub 4 1 roll 3 -1 roll 1.000000 cvr exch sub 3 1 roll 2 -1 roll 1.000000 cvr exch sub 2 1 roll pop } endstream endobj 217 0 obj <> endobj 219 0 obj <> endobj 99 0 obj <> endobj 220 0 obj <>stream Adobe Illustrator CS6 (Windows) 2021-04-12T11:45:36+05:00 2021-06-02T10:28:09+05:00 2021-06-02T10:28:09+05:00 1 False False 20.868494 3.999928 Millimeters Cyan Magenta Yellow Black Default Swatch Group 0 C=0 M=24 Y=86 K=0 PROCESS 100.000000 CMYK 0.000000 23.504999 86.022697 0.000000 C=69 M=8 Y=21 K=0 PROCESS 100.000000 CMYK 69.369003 7.635600 20.892700 0.000000 C=0 M=89 Y=68 K=0 PROCESS 100.000000 CMYK 0.000000 88.946404 67.623398 0.000000 C=15 M=94 Y=99 K=4 PROCESS 100.000000 CMYK 14.578501 94.070297 99.160698 4.416000 C=0 M=0 Y=0 K=84 PROCESS 100.000000 CMYK 0.000000 0.000000 0.000000 84.000000 C=0 M=0 Y=0 K=35 PROCESS 100.000000 CMYK 0.000000 0.000000 0.000000 35.000000 C=0 M=0 Y=0 K=60 PROCESS 100.000000 CMYK 0.000000 0.000000 0.000000 60.000004 Document application/pdf proof:pdf xmp.did:804244B35A9BEB118A6FC3C256996E2F uuid:08e30110-bdb7-4606-97ca-63fb62cbcecc uuid:21079f76-f6d7-4329-b725-f2fb35af5114 uuid:722f8893-0b3c-4402-87fb-c713f1fa0e26 uuid:21079f76-f6d7-4329-b725-f2fb35af5114 uuid:21079f76-f6d7-4329-b725-f2fb35af5114 proof:pdf saved xmp.iid:804244B35A9BEB118A6FC3C256996E2F 2021-04-12T11:45:42+05:00 Adobe Illustrator CS6 (Windows) / endstream endobj 212 0 obj <>/Border[0 0 0]/H/N/Rect[366.504 739.008 429.659 723.67]/Subtype/Link/Type/Annot>> endobj 221 0 obj <> endobj 76 0 obj <>/ExtGState<>/Font<>/ProcSet[/PDF/Text/ImageC/ImageI]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 77 0 obj <>/ExtGState<>/Font<>/ProcSet[/PDF/Text/ImageC/ImageI]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 78 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 79 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 80 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 241 0 obj [243 0 R 244 0 R 245 0 R] endobj 242 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.007 Tc 0.349 Tw 8 0 0 8 70.8661 731.2159 Tm (10.)Tj /Span<>> BDC ( )Tj EMC 1.823 0 Td [(Cor)-21.7(te C, e)-11.7(t al. Asso)-15.8(c)-23.6(ia)15.3(t)-31.7(ion be)-11.7(t)-31.7(ween t)-12.7(he ul)16.3(cer)-32.7(a)15.3(t)-31.8(i)-15.7(ve col)-30.8(i)-23.6(t)-31.8(is)7( )]TJ 0 Tc 0.068 Tw -1.823 -1.25 Td [(end)-16(oscopic inde)-18(x of sever)-36.9(i)-24(t)-10(y \(UCEIS\) and outcomes in a)-17(cute sever)-24(e )]TJ 0.023 Tw 0 -1.25 TD [(ul)16(cer)-33(a)15.1(t)-32(i)-16(ve col)-31(i)-24(t)-31.9(is. Jour)-15(nal of Cr)-32(ohn\245s & Col)-30.9(i)-24(t)-32(is. 2015;5\(9\):376\226381.)]TJ 0.303 Tw T* (11.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Gibson DJ, e)-12(t al. CRP/Albumin R)-10(a)15(t)-32(io: An Ear)-29.9(l)35(y P)35(r)-24(edic)-16(t)17(or of )]TJ 0.003 Tw -1.796 -1.25 Td [(S)15(ter)-32(oid R)13(esponsi)-15.9(veness in A)-25(cute Sever)-23.9(e Ul)16(cer)-33(a)15(t)-32(i)-15.9(ve Col)-31(i)-24(t)-31.9(is. )]TJ /T1_1 1 Tf [(Jour)-14(nal of )]TJ 0.023 Tw T* (Clinical Gastroenterology.)Tj /T1_0 1 Tf ( 2018;6\(52\):e48\226e52.)Tj 0.174 Tw T* (12.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Xie T, e)-12(t al. F)10(ecal calp)25(r)-32(o)17(tec)-16(t)-32(in as an al)56(ter)-14.9(na)14.9(t)-31.9(i)-16(ve t)17(o ul)16(cer)-33(a)15(t)-32(i)-16(ve )]TJ 0.016 Tw -1.796 -1.25 Td [(col)-31(i)-23.9(t)-32(is end)-16(oscopic inde)-18(x of sever)-37(i)-23.9(t)-10(y t)17(o p)24.9(r)-23.9(edic)-16(t t)-13(he r)-24(esponse t)17(o cor)-22(t)-32(i)]TJ 0 Tw (-)Tj 0.036 Tw T* [(coster)-32(oids of a)-17(cute sever)-24(e ul)16(cer)-33(a)15(t)-31.9(i)-16(ve col)-31(i)-24(t)-32(is: A p)25(r)-31.9(ospec)-16(t)-32(i)-16(ve obser)-32(v)-14.9(a)]TJ 0 Tw (-)Tj -0.019 Tw T* [(t)-32(ional stud)17(y. )]TJ /T1_1 1 Tf [(Dig)12(estiv)13.1(e and Liv)13(er Disease: Of)-40(f)-43(icial )0.5(Jour)-14(nal of the Italian )]TJ -0.014 Tw T* [(Society of Gastroenterology )0.5(and the Italian Association for the S)28(tudy of )]TJ 0.023 Tw T* [(the Liv)13(er. )]TJ /T1_0 1 Tf 0 Tw (2017;9\(49\):984\226990.)Tj 0.106 Tw T* (13.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Jain S, e)-11.9(t al. F)20(aecal Calp)25(r)-32(o)17(tec)-15.9(t)-32(in and UCEIS P)35(r)-23.9(edic)-16(t S)-16(hor)-21.9(t-ter)-16(m )]TJ 0.026 Tw -1.796 -1.25 Td [(Outcomes in A)-25(cute Sever)-24(e Col)-31(i)-23.9(t)-32(is: P)35(r)-32(ospec)-16(t)-32(i)-16(ve Cohor)-21.9(t S)15(tud)17.1(y. )]TJ /T1_1 1 Tf 0 Tw [(Jour)-13.9(nal )]TJ 0.023 Tw T* (of Crohn\242s & Colitis.)Tj /T1_0 1 Tf ( 2017;11\(11\):1309\2261316.)Tj 0.248 Tw T* (14.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Choy MC. e)-12(t al. P)35(r)-24(edic)-16(t)-32(ing r)-23.9(esponse af)-28(ter infl)-31(iximab sal)30(v)-15(a)-17(ge )]TJ 0.167 Tw -1.796 -1.25 Td [(in a)-17(cute sever)-23.9(e ul)16(cer)-33(a)15(t)-32(i)-16(ve col)-31(i)-24(t)-32(is. )]TJ /T1_1 1 Tf [(Jour)-13.9(nal of Gastroenterology and )]TJ 0 Tw T* (Hepatology.)Tj /T1_0 1 Tf 0.023 Tw ( 2018;7\(33\):1347\2261352.)Tj 0.254 Tw T* (15.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Xie T, )0.5(e)-12(t al. Ul)16(cer)-33(a)15(t)-32(i)-16(ve )0.5(Col)-31(i)-24(t)-32(is End)-16(oscopic Inde)-18(x )0.5(of Sever)-37(i)-23.9(t)-10(y )]TJ 0.165 Tw -1.796 -1.25 Td [(\(UCEIS\) ver)-9.9(sus Ma)15(yo End)-16(oscopic S)-23.9(cor)-24(e \(MES\) in guiding t)-12.9(he need )]TJ 0.032 Tw T* [(for colec)-16(t)17(omy in p)32(a)15(t)-32(ients wi)-24(t)-13(h a)-17(cute sever)-23.9(e col)-31(i)-23.9(t)-32(is. )]TJ /T1_1 1 Tf 0 Tw (Gastroenterology )Tj T* [(R)21(epor)-40(t.)]TJ /T1_0 1 Tf 0.023 Tw ( 2018;1\(6\):38\22644.)Tj 0.31 Tw T* (16.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Dal)-16(al RS, e)-11.9(t al. A User-F)10.1(r)-37(iendl)35(y P)35(r)-24(edic)-16(t)-32(ion T)45(o)-16(ol t)17(o Ident)-32(if)-33.9(y )]TJ 0.245 Tw -1.796 -1.25 Td [(Colec)-16(t)17(omy R)-23.9(isk in P)40(a)15(t)-32(ients W)-16(i)-23.9(t)-13(h Ul)16(cer)-33(a)15(t)-32(i)-15.9(ve Col)-31(i)-24(t)-32(is. )]TJ /T1_1 1 Tf 0 Tw [(Inf)-21.9(lammator)-42.9(y )]TJ 0.023 Tw T* [(Bow)12(el Diseases.)]TJ /T1_0 1 Tf ( 2019;9\(25\):1550\2261558.)Tj 0.082 Tw T* (17.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Ghoshal UC, e)-12(t al. P)35(r)-23.9(edic)-16(t)-32(ion of outcome of tr)-23.9(ea)15(tment of a)-17(cute )]TJ 0.266 Tw -1.796 -1.25 Td [(sever)-23.9(e ul)16(cer)-33(a)15(t)-32(i)-16(ve col)-30.9(i)-24(t)-32(is using p)25(r)-37(inc)-23.9(ip)32(al com)10(ponent anal)35(y)-13(sis and )]TJ 0.059 Tw T* [(ar)-22(t)-32(if)-27.9(ic)-24(ial intell)-30.9(igence. )]TJ /T1_1 1 Tf [(JGH )0.5(open: an )0.5(open access )0.5(jour)-14(nal )0.5(of g)12(astroen)]TJ 0 Tw (-)Tj 0.023 Tw T* (terology and hepatology.)Tj /T1_0 1 Tf ( 2020;5\(4\):889\226897.)Tj 0.147 Tw T* (18.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(G)20(r)-33(ant RK, e)-12(t al. T)47(he A)16(CE \(Albumin, CRP and End)-15.9(oscopy\) Inde)-18(x )]TJ 0.061 Tw -1.796 -1.25 Td [(in A)-25(cute Col)-31(i)-23.9(t)-32(is: A S)-16(im)10(ple Cl)-31(inical Inde)-17.9(x on A)15(dmission t)-13(ha)15(t P)35(r)-24(edic)-16(ts )]TJ 0.232 Tw T* [(Outcome in P)40(a)15(t)-32(ients W)-16(i)-24(t)-13(h A)-25(cute Ul)16(cer)-33(a)15(t)-32(i)-16(ve Col)-31(i)-24(t)-32(is. )]TJ /T1_1 1 Tf 0 Tw [(Inf)-21.9(lammator)-42.9(y )]TJ 0.023 Tw T* [(Bow)12(el Diseases.)]TJ /T1_0 1 Tf ( 2021;4\(27\):451\226457.)Tj 0.272 Tw T* (19.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(A)30(t)-32(ia O, e)-12(t al. T)47(he pedia)15(tr)-36.9(ic ul)16.1(cer)-33(a)15(t)-32(i)-16(ve col)-30.9(i)-24(t)-32(is a)-17(c)-16(t)-32(i)-16(v)-15.9(i)-24(t)-10(y inde)-18(x )]TJ 0.097 Tw -1.796 -1.25 Td [(\(PUC)20(AI\) p)24.9(r)-23.9(edic)-16(ts ster)-31.9(oid-f)16(ail)35(ur)-24(e in adul)56(ts wi)-23.9(t)-13(h a)-17(cute sever)-24(e col)-31(i)-23.9(t)-32(is. )]TJ /T1_1 1 Tf 0.023 Tw T* [(Scandinavian Jour)-14(nal of Gastroenterology.)]TJ /T1_0 1 Tf ( 2021;9\(56\):1049\2261055.)Tj 0.03 Tw T* (20.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Sahu P, e)-12(t al. P)35(r)-32(ospec)-15.9(t)-32(i)-16(ve v)-15(al)-31(id)42(a)15(t)-32(ion of AIIMS inde)-18(x as a p)25(r)-23.9(edic)]TJ 0 Tw (-)Tj 0.024 Tw -1.796 -1.25 Td [(t)17(or of ster)-32(oid f)16(ail)35(ur)-24(e in p)32(a)15(t)-32(ients wi)-24(t)-12.9(h a)-17(cute sever)-23.9(e ul)16(cer)-33(a)15(t)-32(i)-16(ve col)-30.9(i)-24(t)-32(is. )]TJ /T1_1 1 Tf 0.249 Tw T* [(Indian Jour)-13.9(nal of Gastroenterology: Of)-40(f)-43(icial Jour)-14(nal of the Indian )]TJ 0.023 Tw T* (Society of Gastroenterology.)Tj /T1_0 1 Tf ( 2022;3\(41\):273\226283.)Tj 0.082 Tw T* (21.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(T)40(anak)-17(a M, e)-12(t al. L)35(o)-14(w ser)-22(um albumin a)15(t admission is a p)25(r)-23.9(edic)-16(t)17(or )]TJ 0.165 Tw -1.796 -1.25 Td [(of )0.5(ear)-29.9(l)35(y )0.5(colec)-16(t)17(omy )0.6(in )0.5(p)32(a)15(t)-32(ients )0.6(wi)-24(t)-13(h )0.6(moder)-33(a)15(te )0.5(t)17(o )0.6(sever)-24(e )0.6(ul)16(cer)-33(a)15(t)-32(i)-16(ve )]TJ 0 Tw T* [(col)-31(i)-23.9(t)-32(is. )]TJ /T1_1 1 Tf 0.217 Tw 3.328 0 Td [(JGH open: )0.5(an open access )0.5(jour)-13.9(nal of g)12(astroenterology )0.5(and )]TJ 0 Tw -3.328 -1.25 Td (hepatology.)Tj /T1_0 1 Tf 0.023 Tw ( 2021;3\(5\):377\226381.)Tj 0.194 Tw T* (22.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Sy)22(al G, e)-12(t al. Hypoalbuminemia and Bandemia P)35(r)-24(edic)-16(t F)19.9(ail)35.1(ur)-24(e )]TJ 0.249 Tw -1.796 -1.25 Td [(of Infl)-31(iximab R)13(escue T)47(her)-33(apy in A)-25(cute Sever)-23.9(e Ul)16(cer)-32.9(a)14.9(t)-31.9(i)-16(ve Col)-31(i)-24(t)-32(is. )]TJ /T1_1 1 Tf 0.023 Tw T* [(Dig)12(estiv)13(e Diseases and Sciences.)]TJ /T1_0 1 Tf ( 2021;1\(66\):199\226205.)Tj 0.117 Tw T* (23.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Jain S, e)-12(t al. High mucosal cy)-16(t)17.1(omegal)30(ov)-16(ir)-22(us DN)13(A helps p)25(r)-24(edic)-16(t )]TJ 0.002 Tc 0.349 Tw -1.796 -1.25 Td [(ad)-16.9(ver)-10(se shor)-21.9(t-ter)-16(m outcome in a)-17(cute sever)-23.9(e ul)16(cer)-33(a)15.1(t)-32(i)-15.9(ve col)-31(i)-23.9(t)-32(is.)2( )]TJ /T1_1 1 Tf 0 Tc 0.023 Tw 29.055 60 Td [(Intestinal R)21(esearch.)]TJ /T1_0 1 Tf ( 2021;4\(19\):438\226447.)Tj 0.022 Tw T* (24.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(L)35(e Baut G, e)-12(t al. A S)-24(cor)-36.9(ing Sy)-13(stem t)17(o De)-11.9(ter)-16(mine P)40(a)15(t)-32(ients\245 R)-23.9(isk of )]TJ 0.095 Tw -1.796 -1.25 Td [(Colec)-16(t)17.1(omy W)-15.9(i)-24(t)-13(hin 1 Y)30(ear Af)-27.9(ter Hospi)-24(t)15.1(al A)15(dmission for A)-25(cute Sever)-24(e )]TJ 0.001 Tc 0.35 Tw T* [(Ul)15.9(cer)-33.1(a)15(t)-32.1(i)-16(ve Col)-31(i)-24.1(t)-32(is. )]TJ /T1_1 1 Tf 8.221 0 Td [(Clinical Gastroenterology and )0.5(Hepatology: )0.5(The)1( )]TJ 0 Tc 0.114 Tw -8.221 -1.25 Td [(Of)-40(f)-42.9(icial Clinical Practice Jour)-13.9(nal of the Amer)-37(ican Gastroenterological )]TJ 0 Tw T* (Association.)Tj /T1_0 1 Tf 0.023 Tw ( 2021;8\(19\):1602\2261610.e1.)Tj 0.191 Tw T* (25.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(A)15(d)42(ams A, e)-12(t al. Ear)-30(l)35(y mana)-17(gement of a)-17(cute sever)-23.9(e UC in t)-13(he )]TJ 0.132 Tw -1.796 -1.25 Td [(biol)30(o)-16(gics er)-33(a: devel)30(opment and inter)-15(na)15(t)-31.9(ional v)-15(al)-30.9(id)42(a)15(t)-32(ion of a p)25(r)-32(o)-16(g)]TJ 0 Tw (-)Tj 0.305 Tw T* [(nost)-32(ic )0.5(cl)-31(inical inde)-17.9(x t)17(o p)25(r)-24(edic)-15.9(t ster)-32(oid )0.5(r)-24(esponse. )]TJ /T1_1 1 Tf 0 Tw 21.865 0 Td (Gut.)Tj /T1_0 1 Tf 0.305 Tw [( 2022. )0.5(C. )]TJ 0 Tw -21.865 -1.25 Td (gutjnl-2022-327533.)Tj 0.11 Tw T* (26.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Con D, e)-12(t al. Biomar)-24(k)10(er d)17(ynamics dur)-36.9(ing infl)-30.9(iximab sal)30(v)-15(a)-17(ge for )]TJ 0.03 Tw -1.796 -1.25 Td [(a)-17(cute sever)-23.9(e ul)16(cer)-33(a)15(t)-32(i)-16(ve col)-30.9(i)-24(t)-32(is: C-r)-24(ea)-17(c)-15.9(t)-32(i)-16(ve p)25(r)-32(o)17(tein \(CRP\)-l)35(ym)10(pho)-15.9(cy)-16(te )]TJ 0.264 Tw T* [(r)-33(a)15(t)-32(io and CRP-albumin r)-32.9(a)15(t)-32(io ar)-24(e useful in p)25(r)-24(edic)-15.9(t)-32(ing colec)-16(t)17(omy. )]TJ /T1_1 1 Tf 0.023 Tw T* [(Intestinal R)21(esearch.)]TJ /T1_0 1 Tf ( 202;1\(20\):101\226113.)Tj -0.053 Tw T* (27.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Cuschier)-36.9(i S. T)47(he S)-21(TROBE guidel)-30.9(ines. )]TJ /T1_1 1 Tf [(Saudi Jour)-14(nal of Anaesthesia.)]TJ /T1_0 1 Tf 0 Tw ( )Tj -1.796 -1.25 Td (2019;5\(13\):31.)Tj -0.009 Tw T* (28.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(McGuinness L)-34.9(A, Higgins JPT. R)-24(isk-of-bias VISual)-31(iza)15(t)-32(ion \(r)-32(obv)-16(is\): )]TJ 0.064 Tw -1.796 -1.25 Td [(An R p)32(a)-17(ck)-17(a)-17(ge and S)-16(hiny web app for v)-16(isual)-31(izing r)-36.9(isk-of-bias assess)]TJ 0 Tw (-)Tj T* (ments. )Tj /T1_1 1 Tf 0.023 Tw 3 0 Td [(R)21(esearch Synthesis Methods.)]TJ /T1_0 1 Tf ( 2021;1\(12\):55\22661)Tj 0.095 Tw -3 -1.25 Td (29.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Dias )0.5(CC, )0.5(e)-12(t )0.5(al. )0.5(Cl)-31(inical )0.5(p)25(r)-23.9(edic)-16(t)17(or)-10(s )0.5(of )0.5(colec)-16(t)17(omy )0.5(in )0.5(p)32(a)15(t)-32(ients )0.6(wi)-24(t)-13(h )]TJ 0.234 Tw -1.796 -1.25 Td [(ul)16(cer)-33(a)15.1(t)-32(i)-16(ve )0.5(col)-31(i)-23.9(t)-32(is: )0.5(sy)-12.9(stema)15(t)-32(ic )0.5(r)-23.9(ev)-16(iew )0.5(and )0.6(me)-12(t)15(a-anal)35(y)-13(sis )0.6(of )0.5(cohor)-21.9(t )]TJ 0 Tw T* (studies. )Tj /T1_1 1 Tf 0.023 Tw 3.446 0 Td [(Jour)-14(nal of Crohn\242s & Colitis.)]TJ /T1_0 1 Tf ( 2015;2\(9\):156\226163.)Tj 0.091 Tw -3.446 -1.25 Td (30.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(L)35(ee S-H, e)-12(t al. Ear)-30(l)35.1(y Changes in Ser)-21.9(um Albumin P)35(r)-24(edic)-15.9(t Cl)-31(inical )]TJ -0.029 Tw -1.796 -1.25 Td [(and End)-16(oscopic Outcomes in P)40(a)15(t)-32(ients W)-16(i)-23.9(t)-13(h Ul)16(cer)-33(a)15(t)-32(i)-15.9(ve Col)-31(i)-23.9(t)-32(is S)15(t)15(ar)-22(t)-32(ing )]TJ -0.039 Tw T* [(Ant)-32(i-TNF T)50(r)-24(ea)15(tment. )]TJ /T1_1 1 Tf [(Inf)-22(lammator)-42.9(y Bow)12(el Diseases.)]TJ /T1_0 1 Tf ( 2021;9\(27\):1452\226)Tj 0 Tw T* (1461.)Tj 0.165 Tw T* (31.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Header D)20(A, e)-12(t al. C-r)-23.9(ea)-17(c)-16(t)-32(i)-16(ve p)25(r)-32(o)17.1(tein/albumin r)-32.9(a)15(t)-32(io \(C)20(AR\) as a )]TJ 0.269 Tw -1.796 -1.25 Td [(mar)-24(k)10(er for de)-12(tec)-16(t)-31.9(ing a)-17(cute sever)-23.9(e ul)16(cer)-33(a)15(t)-32(i)-16(ve col)-31(i)-23.9(t)-32(is in Eg)16(ypt)-31.9(ian )]TJ 0.016 Tc -0.016 Tw T* [(p)32.5(a)15.5(t)-31.5(i)0.5(e)0.5(n)0.6(t)0.5(s)0.5(.)0.5( )]TJ /T1_1 1 Tf 0.566 Tw 4.558 0 Td [(R)21.5(e)0.5(v)0.5(i)0.5(s)0.5(t)0.6(a)0.5( )0.5(D)0.5(e)0.5( )0.5(G)0.5(a)0.5(s)0.5(t)0.5(r)0.5(o)0.6(e)0.5(n)0.5(t)0.5(e)0.5(r)0.5(o)0.5(l)0.5(o)0.6(g)0.5(i)0.5(a)0.5( )0.5(D)0.5(e)0.5( )0.5(M)0.5(e)-14.5(x)0.5(i)0.6(c)0.5(o)0.5( )0.5(\()0.5(E)0.5(n)0.5(g)13.5(l)0.5(i)0.5(s)0.5(h)0.5(\))0.6(.)]TJ /T1_0 1 Tf 0 Tc 0 Tw 23.08 0 Td ( )Tj -27.638 -1.25 Td (2022;4\(87\):447\226454.)Tj 0.166 Tw T* (32.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Zhang X-F, e)-12(t al. Com)10(p)32(ar)-36.9(ing t)-13(he cl)-31(inical appl)-31(ica)15.1(t)-32(ion v)-15(al)35(ues of )]TJ 0.21 Tw -1.796 -1.25 Td [(t)-13(he Degr)-23.9(ee of Ul)16(cer)-33(a)15(t)-32(i)-15.9(ve Col)-31(i)-24(t)-32(is Bur)-24(den of L)35(uminal Infl)-16(amma)15(t)-32(ion )]TJ 0.072 Tw T* [(\(DUBLIN\) scor)-23.9(e and Ul)16(cer)-32.9(a)15(t)-32(i)-16(ve Col)-31(i)-24(t)-32(is End)-16(oscopic Inde)-18(x of Sever)-37(i)-24(t)-9.9(y )]TJ 0.09 Tw T* [(\(UCEIS\) in p)32(a)15(t)-32(ients wi)-24(t)-13(h ul)16(cer)-33(a)15(t)-32(i)-15.9(ve col)-31(i)-23.9(t)-32(is. )]TJ /T1_1 1 Tf [(Gastroenterol )0.5(R)21(ep \(Oxf\))]TJ /T1_0 1 Tf 0 Tw (. )Tj 0.023 Tw T* (2021 Jul 15;9\(6\):533\226542.)Tj 0.034 Tw T* (33.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(\206\024\035\024\r\036\027\022\024 )0.5(\202.\210., )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 7.527 0 Td [(\f\024\026\r\021. )0.5(\215\030\036\007\017\022\021\024\030\t )0.5(\220\235\235\036\022\021\017\r\027\024\f\021\017 )0.6(\017\027\235\035\017\022)]TJ 0 Tw (-)Tj 0.029 Tw -9.323 -1.25 Td (\f\017\n\026\002\026 \031)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\034\027\t\b \f)Tj /Span<>> BDC ( )Tj EMC (\021\016\032\036\035\024\005 \026\021\026\022\024\005 \016\r\036\027\027\ \024\020\024 \022\024\035\017\021\026. )Tj /T1_1 1 Tf 0 Tw (\212\n\t\t\025\017\t\013\025\017 )Tj 0.01 Tc 0.388 Tw T* [(\241\205\032\021\026\023 \210\026\t\024\032\n\r\021\024\031\032\n\023\n\202\ \025\025, \210\031\033\026\024\n\023\n\202\025\025, \222\n\023\n\033\032\ \n\013\024\n\023\n\202\025\025.)10( )]TJ /T1_0 1 Tf 0 Tc 0.08 Tw T* [(2013;5\(23\). / )0.5(Gol)30(ovenko )0.5(A.O., e)-12(t )0.5(al. P)35(r)-24(edic)-15.9(t)17(or)-10(s of t)-12.9(he ef)-56(fec)-15.9(t)-32(i)-16(veness )]TJ 0.207 Tw T* [(of infl)-31(iximab in p)32(a)15(t)-32(ients wi)-24(t)-13(h sever)-24(e a)15(t)-30(t)15(a)-17(ck of ul)16(cer)-32.9(a)14.9(t)-31.9(i)-16(ve col)-30.9(i)-24(t)-32(is. )]TJ /T1_1 1 Tf 0.008 Tc 0.349 Tw T* [(R)22.4(ussi)0.5(an J)0.5(our)-13.6(na)0.5(l of)0.5( Ga)0.5(stroen)0.5(terolo)0.5(gy, H)0.5(epato)0.5(logy, Colo)0.5(p)46.4(rocto)0.5(logy.)8( )]TJ /T1_0 1 Tf 0 Tc 0.023 Tw T* (2013;5\(23\). \(in Russ.\).)Tj 0.018 Tw T* (34.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (\202\004\022\026\f\024\r \221.\222., \234\026\023\017\027\026 \204.\200.\ , \200\036\f\036\035\024\r \200.\200., \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. \215\030\036\007\017\022\021\024\030\t )Tj 0.333 Tw -1.796 -1.25 Td [(\022\024\035\220\022\021\024\n\017\017 )0.5(\031)]TJ /Span<>> BDC ( )Tj EMC 6.404 0 Td [(\023\026\006\017\036\027\021\024\r )0.5(\f\024 )0.5(\f\r\036\030\b\021\016\032\036\035\t\n )0.5(\016\r\036\027\027\t\n )0.5(\022\024\035\017\021\024\n. )]TJ /T1_1 1 Tf 0 Tw -6.404 -1.25 Td (\222\n\023\n\033\032\n\013\024\n\023\n\202\025\002.)Tj /T1_0 1 Tf 0.321 Tw [( 2020;19\(3\):37\22648. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.33878/2073-7556-)Tj 0.01 Tc -0.01 Tw T* (2020-19-3-37-48)Tj 0 0 0 1 k /GS1 gs 0.389 Tw [( / A)-25.4(chk)-17.5(asov)]TJ /Span<>> BDC ( )Tj EMC [(S.I., S)-16.4(hapina M.V., V)29.5(esel)29.6(ov V.V.,)10( )]TJ 0 Tc 0.144 Tw T* [(e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. P)35(r)-24(edic)-16(t)17(or)-10(s of colec)-16(t)17(omy in p)32(a)15(t)-32(ients wi)-24(t)-13(h \253e)-18(xtr)-24(emel)35.1(y sever)-23.9(e\273 )]TJ 0.289 Tw T* [(ul)16(cer)-33(a)15.1(t)-32(i)-16(ve col)-30.9(i)-24(t)-32(is. )]TJ /T1_1 1 Tf 0 Tw [(K)18(olop)46(roktologia.)]TJ /T1_0 1 Tf 0.289 Tw ( 2020;19\(3\):37\22648. \(in Russ.\). )Tj 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.33878/2073-7556-2020-19-3-37-48)Tj /T1_2 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\214)10(\211\036\033 \035\030\032\t\033)30(\b)42(\032)-21(\240\033\233)]TJ 57.136 0 Td (REVIEW)Tj -57.136 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 23, \023\0221)69(, 202)69(4)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 23, \023\0221)69(, 202)69(4)]TJ /T1_3 1 Tf 25 0 0 25 20.7902 56.0378 Tm (180)Tj ET endstream endobj 243 0 obj <>/Border[0 0 0]/H/N/Rect[452.866 298.512 524.409 289.056]/Subtype/Link/Type/Annot>> endobj 244 0 obj <>/Border[0 0 0]/H/N/Rect[303.307 288.512 359.823 279.216]/Subtype/Link/Type/Annot>> endobj 245 0 obj <>/Border[0 0 0]/H/N/Rect[318.085 258.512 444.893 249.216]/Subtype/Link/Type/Annot>> endobj 248 0 obj <> endobj 247 0 obj <> endobj 246 0 obj <> endobj 239 0 obj [249 0 R 250 0 R 251 0 R] endobj 240 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\034\002\016\201\220\n)-9.9(\026)10.9(\025\002\020 \001\016\f\007\013\202)10(\025\221\002\220\205\026\001\025\202)10.1(\025 \220\006\207\025\201\013 \026)11(\016\002\013\221\220\220 )]TJ 0 -1 TD [(\n)10(\025\002\026\220\n)10(\025\006)-9.9(\026)11(\016\002\025\220\201\013\024\220 \215\022\221\013\227\220\016\001\026)11.1(\025\r \006\022\026\205\217\016\007\025\203 \013\026)11(\013\n)10(\025\203 \205\222\r\016\001\001\025\202)10.1(\025 )]TJ T* [(\n)10(\025\007\220\026)11(\013 \(\006\220\006)-10(\026)11(\016\024\013\026\220\017\016\006\n\220\203 \025\f\222\025\002 \220\022\024\ \016\026)11.1(\013\013\001\013\007\220\222\))]TJ 35.009 2 Td [(Pr)31(edictor)20.1(s of adv)12(er)20(se outcomes of ster)20(oids in patients with se)11(v)12(er)31(e )]TJ 3.699 -1 Td [(ulcer)21(ativ)12.1(e colitis \(s)10(y)10(stematic r)31(e)11(vie)11(w and meta-analy)10(ses\))]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0.037 Tw 10 0 0 10 42.5197 724.8299 Tm (\023\030\017)Tj /Span<>> BDC ( )Tj EMC (\n\036\021\026\026\027\026\035\017\036 \001\022\026\035\t MES \023\024\035\ \031\004\036\027\024 \f\021\026\021\017\f\021\017\004\036\f\022\017 )Tj 0.237 Tw 0 -1.218 TD (\027\026\004\017\n\024\036 \023\024\r\t\001\036\027\017\036 \r\036\030\024\ \016\021\027\024\f\021\017 \(\210\234)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (2,9; 95% )Tj -0.004 Tw T* [(\212\222: )0.5(1,9\2264,3\), )0.5(\024\007\027\026\022\024 )0.6(\r)]TJ /Span<>> BDC ( )Tj EMC 9.317 0 Td [(\026\027\026\035\017 )0.6(\031\007\026\035\024\f\034 )0.5(\r\022\035\033\004\017\021\034 )0.6(\035\017\001\034 )]TJ 0.083 Tw -9.317 -1.218 Td (4 \017\f\f\035\036\007\024\r\026\027\017\016, \017)Tj /Span<>> BDC ( )Tj EMC (\023\024\035\031\004\036\027\024 \027\026\004\036\027\017\036 \r\t\f\024\ \022\024\005 \020\036\021\036)Tj 0 Tw (-)Tj T* (\030\024\020\036\027\027\024\f\021\017 \(I)Tj 5.83 0 0 5.83 99.2488 679.4479 Tm (2)Tj /Span<>> BDC 10 0 0 10 102.1638 676.1179 Tm ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (76%\).)Tj 0.103 Tw -5.964 -1.218 Td (\210\021\007\036\035\034\027\024 \f\021\024\017\021 \031\023\024\n\016\027\ \031\021\034, \004\021\024 \031\030\024\r\036\027\034 \020\036\n\024\020\ \035\024\002\017\027\026 )Tj 0.187 Tw T* (\021\024\032\036 \023\030\024\007\036\n\024\027\f\021\030\017\030\024\r\026\ \035 \f\021\026\021\017\f\021\017\004\036\f\022\031\033 \027\026\004\017\ \n\031\033 )Tj -0.051 Tw 0 -1.218 TD (\030\026\027\017\006\031 \f\030\036\007\027\017\b \027\026\004\036\027\ \017\005 \023\036\030\036\007 \027\026\004\026\035\024\n \020\024\030\n\024\ \027\026\035\034)Tj 0 Tw (-)Tj 0.003 Tw 0 -1.218 TD (\027\024\005 \021\036\030\026\023\017\017 \n\036\032\007\031 \020\030\031\ \023\023\026\n\017. \210\007\027\026\022\024 \030\026\027\017\006\026 \n\ \036\032\007\031 )Tj 0.147 Tw 0 -1.218 TD [(\020\030\031\023\023\026\n\017 )0.5(\f\024\f\021\026\r\017\035\026 )0.5(\024\022\024\035\024 )0.5(8 \020/\035 )0.5(\(95% )0.5(\212\222: \25710,1)]TJ /Span<>> BDC ( )Tj EMC 21.11 0 Td (\227 )Tj 0 Tw -21.11 -1.218 Td (\2575,8\), \004\021\024 \016\r\035\016\036\021\f\016 \022\035\017\027\017\ \004\036\f\022\017 \027\036\027\026\004\017\n\t\n.)Tj 0.1 Tw 0 -1.218 TD (\215\030\024\r\036\007\036\027\027\t\005 \n\036\021\026\026\027\026\035\017\  \n\024\032\036\021 \017\n\036\021\034 \030\016\007 \f\017\f\021\036\n\026\ )Tj 0 Tw (-)Tj 0.26 Tw 0 -1.218 TD (\021\017\004\036\f\022\017\b \f\n\036\013\036\027\017\005 \017)Tj /Span<>> BDC ( )Tj EMC (\024\020\030\026\027\017\004\036\027\017\005. \215\030\036\032\007\036 \r\ \f\036\020\024, )Tj 0.124 Tw 0 -1.218 TD [(\f\021\024\017\021 )0.5(\036\013\036 )0.5(\030\026 )0.6(\024\021\n\036\021\017\021\034, )0.5(\004\021\024 )0.5(\r\022\035\033\004\036\027\027\t\036 )0.6(\r)]TJ /Span<>> BDC ( )Tj EMC 18.485 0 Td (\f\017\f\021\036\n\026)Tj 0 Tw (-)Tj 0.166 Tw -18.485 -1.218 Td (\021\017\004\036\f\022\017\005 \024\002\024\030 \030\026\002\024\021\t \ \023\030\036\007\f\021\026\r\035\016\033\021 \f\024\002\024\005 \024\002\ \f\036\030)Tj 0 Tw (-)Tj 0.316 Tw T* [(\r\026\006\017\024\027\027\t\036 )0.6(\017\f\f\035\036\007\024\r\026\027\017\016 )0.5(\(\022\024\020\024\030\021\027\t\036 )0.6(\017\035\017 )0.5(\023\024)]TJ /Span<>> BDC ( )Tj EMC 20.266 0 Td (\021\017\023\031 )Tj 0.031 Tw -20.266 -1.218 Td (\253\f\035\031\004\026\005-\022\024\027\021\030\024\035\034\273\). \221)Tj /Span<>> BDC ( )Tj EMC (\220\021\017\n \f\r\016\026\027\024 \023\030\036\r\026\035\017\030\024\r\ \026\027\017\036 )Tj 0.454 Tw 0 -1.218 TD [(\023\031\002\035\017\022\026\006\017\005 \f\024 \f\030\036\007\027\017\n\ )0.5(\030\017\f\022\024\n \f\017\f\021\036\n\026\021\017\004\036\f\022\024\005\ )]TJ 0.012 Tw 0 -1.218 TD (\024\001\017\002\022\017 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\024\006\036\027\022\036 \023\024)Tj /Span<>> BDC ( )Tj EMC (\004\036\022-\035\017\f\021\031 ROBINS-E. \224\021\024 \024\002\031\f)Tj 0 Tw (-)Tj 0.319 Tw 0 -1.218 TD (\035\024\r\035\036\027\024 \030\026\027\024\030\024\007\027\024\f\021\034\ \033 \017\031\004\026\036\n\024\005 \020\030\031\023\023\t \023\026\006\ \017)Tj 0 Tw (-)Tj 0.148 Tw 0 -1.218 TD (\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\027\026\035\017\004\017\036\n \002\024\035\034\001\024\020\024 \004\017\ \f\035\026 \026\027\026\n\027\036\f\021\017\004\036\f\022\017\b )Tj 0.034 Tw 0 -1.218 TD (\007\026\027\027\t\b, \023\030\024\f\035\036\007\017\021\034 \017)Tj /Span<>> BDC ( )Tj EMC (\031\004\036\f\021\034 \022\024\021\024\030\t\036 \022\030\026\005\027\036\ \026\021\030\031\007)Tj 0 Tw (-)Tj 0.07 Tw 0 -1.218 TD (\027\017\021\036\035\034\027\024. \215\030\017)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\n \024\007\027\024 \017\f\f\035\036\007\024\r\026\027\017\036\ \017\n\036\035\024 \r\t\f\024)Tj 0 Tw (-)Tj T* (\022\017\005 \030\017\f\022 \f\017\f\021\036\n\026\021\017\004\036\f\022\ \024\005 \024\001\017\002\022\017.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 42.5896 408.2018 Tm [(\020)21(\026\027\r\242\224\034\022\031\034)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0.158 Tw 10 0 0 10 42.5197 383.8458 Tm [(\230\026\022\017\n \024\002\030\026\024\n, \023\030\017\027\017\n\026\016\ \r\024 \r\027\017\n\026\027\017\036 \024\023\017\f\026\027\027\t\036)10( )]TJ 0.222 Tw T* (\024\020\030\026\027\017\004\036\027\017\016, \r)Tj /Span<>> BDC ( )Tj EMC (\030\036\031\035\034\021\026\021\036 \023\030\024\r\036\007\036\027\027\ \024\020\024 \f\017\f\021\036\n\026)Tj 0 Tc 0 Tw (-)Tj 0.01 Tc 0.315 Tw T* (\021\017\004\036\f\022\024\020\024 \024\002\024\030\026 \017)Tj /Span<>> BDC ( )Tj EMC [(\n\036\021\026\026\027\026\035\017\026 \002\t\035\017 \r\t\016\r\035\036\ \027\t)10( )]TJ 0.429 Tw T* (\023\030\036\007\017\022\021\024\030\t, \026\f\f\024\006\017\017\030\024\ \r\026\027\027\t\036 \f)Tj /Span<>> BDC ( )Tj EMC (\030\026\r\017\021\017\036\n \020\024\030)Tj 0 Tc 0 Tw (-)Tj 0.01 Tc 0.591 Tw T* (\n\024\027\026\035\034\027\024\005 \030\036\017\f\021\036\027\021\027\024\ \f\021\017. \222\n\017 \f\021\026\035\017 \253\023\030\024\021\016)Tj 0 Tc 0 Tw (-)Tj 0.01 Tc 0.228 Tw T* [(\032\036\027\027\024\f\021\034 \023\024\030\026\032\036\027\017\016 \f\035\ \017\017\f\021\024\005 \024\002\024\035\024\004\022\017 \021\024\035\f\021\ \024\005)10( )]TJ 0.129 Tw T* (\022\017\001\022\017\273, \026)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\032\036 \r\t\030\026\032\036\027\027\024\f\021\034 \017\n\036\ \027\036\027\017\005 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\022\024)Tj 0 Tc 0 Tw (-)Tj 0.01 Tc -0.019 Tw T* (\035\024\027\024\f\022\024\023\017\017 \(UCEIS)Tj /Span<>> BDC ( )Tj EMC (\241)Tj /Span<>> BDC ( )Tj EMC (7 \002\026\035\035\024\r\). \230\026\022\032\036 \002\t\035\026 \r\t\016\ \r\035\036)Tj 0 Tc 0 Tw (-)Tj 0.01 Tc 0.098 Tw T* [(\027\026 \023\030\016\n\026\016 \r\026\017\n\024\f\r\016\034 \n\036\032\ \007\031 \020\017\023\024\026\035\034\002\031\n\017\027\036\n\017\036\005\ ,)10( )]TJ 0.082 Tw 23.244 43.841 Td (\r\t\f\024\022\017\n \031\030\024\r\027\036\n \221-\030\036\026\022\021\017\ \r\027\024\020\024 \002\036\035\022\026 \023\036\030\036\007 \027\026\004\ \026)Tj 0 Tc 0 Tw (-)Tj 0.01 Tc 0.022 Tw 0 -1.218 TD (\035\024\n \017)Tj /Span<>> BDC ( )Tj EMC 2.633 0 Td [(\027\026 )0.5(3)]TJ /Span<>> BDC ( )Tj EMC 2.033 0 Td (\f\031\021\022\017 \035\036\004\036\027\017\016 \022\024\030\021\017\022\ \024\f\021\036\030\024\017\007\026\n\017 \017)Tj /Span<>> BDC ( )Tj EMC 15.67 0 Td (\030\026)Tj 0 Tc 0 Tw (-)Tj 0.01 Tc 0.137 Tw -20.336 -1.218 Td (\r\017\021\017\036\n \027\036\002\035\026\020\024\023\030\017\016\021\027\ \024\020\024 \017\f\b\024\007\026)Tj /Span<>> BDC ( )Tj EMC [(\227 \020\024\030\n\024\027\026\035\034\027\024\005)10( )]TJ 0.326 Tw 0 -1.218 TD [(\030\036\017\f\021\036\027\021\027\024\f\021\017, \021\030\036\002\031\033\ \013\036\005 \023\030\024\r\036\007\036\027\017\016 \253\021\036\030\026\ \023\017\017)10( )]TJ 0.008 Tw 0 -1.218 TD (\017\035\017 \b\017\030\031\030\020\017\017 \f\023\026\f\036\027\017\016\ \273 \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\021\016\032\036\035\024\005 \026\021\026)Tj 0 Tc 0 Tw (-)Tj 0.01 Tc 0 -1.218 TD (\022\024\005 \247\025.)Tj /T1_3 1 Tf 0 Tc 0.023 Tw 0 -2.436 TD (\223\030\032\255\020\034\036 \032\026\020\017\022\017\026)Tj /T1_1 1 Tf 0.229 Tw 0 -1.218 TD [(\025)-4.1(\024)-4.3(\027)1.7(\006)-6(\036)-6.8(\023)2.2(\006)-6(\017)-5.4(\016 \017)]TJ /Span<>> BDC ( )Tj EMC [(\007)-6(\017)2.7()-9.9(\026\005)1.7(\027 \017)-2.4(\f)3.1(\f)-38.9(\035)-6.8(\036)-19(\007)-4.4(\024)-4.3(\r)-8.9(\026\027)1.8(\017)-5.5(\016)13.7(:)]TJ /T1_4 1 Tf -0.007 Tc 0.236 Tw [( \240)3.6(\025\021)8.1(\202\026)-6.4(\016)-4.8(\n)2.6(\027)]TJ /Span<>> BDC 19.84 0 Td ( )Tj EMC [(\201)-9.3(.)69.5(\225)47.7(.)0.8(,)-7( )]TJ 0 Tc 0 Tw -19.84 -1.218 Td [(\201)28.6(\006)10.7(\013)12.7(\026\t)9.8(\n)9.7(\027)]TJ /Span<>> BDC ( )Tj EMC [(\207)-2.1(.)29.3(\215)28.8(.)7.8(, \207)27.6(\205)9.3(\001)7.2(\013)9.8(\n)9.7(\027)]TJ /Span<>> BDC ( )Tj EMC [(\255)27.6(.)29.3(\215)28.8(.)7.8(, \213)5.1(\026)1.8(\032)3(\026)4.3(\021)3.8(\n)9.6(\027)2.1(\026)]TJ /Span<>> BDC ( )Tj EMC [(\220)65(.)7.4(\201)-2.3(.)7.8(, \222)16.1(\026)-5.2(\023)9(\026)4.3(\021)3.8(\n)9.7(\027)]TJ /Span<>> BDC ( )Tj EMC [(\213)18.5(.)29.3(\212)93.9(.)]TJ /T1_1 1 Tf 0 -1.218 TD [(\221)-4.6(\002)-9.9(\024)0.7(\030 \017)]TJ /Span<>> BDC ( )Tj EMC [(\024)-11.8(\002)3(\030)-11.3(\026)-6.4(\002)-9.9(\024)-10.8(\021)-17.7(\022)-19.1(\026 \n)1.3(\026)-11.8(\021)-9.9(\036)-1.7(\030)-7.6(\017)-0.6(\026)-33.1(\035\026)3.7(:)]TJ /T1_4 1 Tf -0.007 Tc 0.007 Tw [( \240)3.7(\025\021)8.2(\202\026)-6.4(\016)-4.8(\n)2.6(\027)]TJ /Span<>> BDC 16.284 0 Td ( )Tj EMC [(\201)-9.3(.)69.5(\225)47.7(.)]TJ /T1_1 1 Tf 0.018 Tc -0.018 Tw -16.284 -1.218 Td [(\221)35.2(\021)-3.5(\026)6.2(\021\017)15.7(\f)-18(\021\017)22.5(\004)9.8(\036)7.6(\f)16.4(\022)-1.1(\026)-3(\016)18( \024)6.2(\002)21(\030)6.6(\026)11.7(\002)8.1(\024)7.1(\021\022)-1(\026)21.7(:)]TJ /T1_4 1 Tf -0.007 Tc 0.007 Tw 11.349 0 Td [( \240)3.6(\025\021)8.1(\202\026)-6.4(\016)-4.8(\n)2.6(\027)]TJ /Span<>> BDC 4.055 0 Td ( )Tj EMC [(\201)-9.3(.)69.5(\225)47.7(.)]TJ /T1_1 1 Tf 0.002 Tc -0.002 Tw -15.404 -1.218 Td [(\203)7.2(\026\023)4.2(\017\f)-10.8(\026)1.7(\027)3.7(\017)-6.7(\036)2.1( \021)-7.9(\036)-3.4(\022\f)-34(\021)-19.5(\026)5.7(:)]TJ /T1_4 1 Tf -0.007 Tc 0.007 Tw 7.694 0 Td [( \240)3.6(\025\021)8.1(\202\026)-6.4(\016)-4.8(\n)2.6(\027)]TJ /Span<>> BDC 4.055 0 Td ( )Tj EMC [(\201)-9.3(.)69.5(\225)47.7(.)]TJ /T1_1 1 Tf 0 Tc 0 Tw -11.749 -1.218 Td [(\217)5.5(\036)-19(\007)-20.1(\026\022)-32.6(\021)-17.7(\017)1.4(\030)-11.8(\024)-4.2(\r)-9(\026\027)1.8(\017)-8.7(\036)6.5(:)]TJ /T1_4 1 Tf -0.029 Tc 0.029 Tw [( \201\006)-18.3(\013)-16.3(\026)-28.6(\t)-19.2(\n)-19.4(\027)]TJ /Span<>> BDC 10.569 0 Td ( )Tj EMC [(\207)-31.1(.\215.)-21.2(,)-29( \207)-1.4(\205)-19.7(\001)-21.8(\013)-19.2(\n)-19.4(\027)]TJ /Span<>> BDC 5.175 0 Td ( )Tj EMC [(\255)-1.4(.\215.)]TJ /T1_3 1 Tf 0 Tc 0.023 Tw -15.743 -2.436 Td (AUTHORS CONTRIBUTION)Tj /T1_1 1 Tf 0.211 Tw T* [(C)-6.5(o)0.8(nce)-0.7(p)-12.3(t a)2.4(n)-4.6(d d)-5.5(e)-13.3(s)-16.6(i)3.2(g)1.2(n o)-2.2(f t)-16.7(h)-5.3(e s)-20(t)-12.8(ud)-10.9(y)-11.8(:)]TJ /T1_4 1 Tf [( A)9.6(i)9.4(r)7.7(a)-4.9(t)]TJ /Span<>> BDC ( )Tj EMC [(F)65.2(.)]TJ /Span<>> BDC ( )Tj EMC [(M)10.5(i)8.4(n)3.8(ga)-4.5(z)12.4(o)-0.6(v)33.6(, )]TJ -0.002 Tw T* [(S)5.6(e)-1.7(r)2.3(g)-2.5(e)-2.5(y)]TJ /Span<>> BDC ( )Tj EMC [(I)2.4(.)]TJ /Span<>> BDC ( )Tj EMC [(A)0.9(c)1.8(h)7.5(k)15.8(a)-3(s)4.9(o)-0.6(v)33.6(, O)-7.3(l)4.8(e)-3.5(g)]TJ /Span<>> BDC ( )Tj EMC [(I)2.4(.)]TJ /Span<>> BDC ( )Tj EMC [(S)15.8(us)9.6(h)7.6(k)12.9(o)-0.6(v)33.6(, T)49.7(a)-4.9(t)-25.2(i)5.9(a)-0.8(n)4.8(a)]TJ /Span<>> BDC ( )Tj EMC [(A)-12.6(.)]TJ /Span<>> BDC ( )Tj EMC [(B)6.7(ar)7.7(a)-0.8(n)1.9(ov)10.8(a)-14(, )]TJ -0.003 Tc 0.003 Tw T* [(B)4(ula)-7.9(t)]TJ /Span<>> BDC 2.1 0 Td ( )Tj EMC [(R)-5.5(.)]TJ /Span<>> BDC 1.047 0 Td ( )Tj EMC [(K)9.8(a)-3.1(la)-3.8(n)-1.1(o)-3.6(v)]TJ /T1_1 1 Tf 0 Tc -0.095 Tw -3.147 -1.218 Td [(C)-6.5(o)-5.8(l)-19(l)-14.3(e)-9.4(c)-32.5(t)-37.3(i)3.2(o)0.8(n a)2.4(n)-4.6(d )0.5(p)-3.8(r)-6(o)-7(ce)-13.3(s)-12.8(s)-16.6(i)7.1(n)-1.9(g )0.5(o)-2.2(f m)1.8(a)-8.4(t)-15.2(e)-2.1(r)-47.9(i)5.1(a)-1.5(l)-44.6(s)2.2(:)]TJ /T1_4 1 Tf [( A)9.7(i)9.4(r)7.7(a)-4.9(t)]TJ /Span<>> BDC ( )Tj EMC [(F)65.2(.)]TJ /Span<>> BDC ( )Tj EMC 18.482 0 Td [(M)10.5(i)8.4(n)3.8(ga)-4.5(z)12.4(o)-0.6(v)]TJ /T1_1 1 Tf -0.007 Tc 0.007 Tw -18.482 -1.218 Td [(St)-34.7(a)-15.4(t)-44.4(i)-4.3(s)-27(t)-44.4(i)-1.8(c)-18.8(a)-8.5(l)-7( p)-10.8(r)-13(o)-13.9(c)-6.9(e)-20.2(s)-19.8(s)-23.6(in)-8.9(g)2(:)]TJ /T1_4 1 Tf 0 Tc 0 Tw 9.088 0 Td [( A)9.6(i)9.4(r)7.7(a)-4.9(t)]TJ /Span<>> BDC ( )Tj EMC [(F)65.3(.)]TJ /Span<>> BDC ( )Tj EMC [(M)10.5(i)8.4(n)3.8(ga)-4.5(z)12.4(o)-0.6(v)]TJ /T1_1 1 Tf -0.052 Tc 0.052 Tw -9.088 -1.218 Td [(Te)-75.9(x)-88(t)-52( w)-73(r)-99.9(i)-58(t)-89.4(i)-44.9(n)-53.9(g)-43(:)]TJ /T1_4 1 Tf 0 Tc 0 Tw 5.233 0 Td [( A)9.6(i)9.4(r)7.7(a)-4.9(t)]TJ /Span<>> BDC ( )Tj EMC [(F)65.3(.)]TJ /Span<>> BDC ( )Tj EMC [(M)10.5(i)8.4(n)3.8(ga)-4.5(z)12.4(o)-0.6(v)]TJ /T1_1 1 Tf 0.006 Tc -0.006 Tw -5.233 -1.218 Td [(E)11.6(dit)-31.4(i)13.1(n)4.1(g)15(:)]TJ /T1_4 1 Tf 0 Tc 0 Tw 3.238 0 Td [( S)5.6(e)-1.7(r)2.3(g)-2.5(e)-2.5(y)]TJ /Span<>> BDC ( )Tj EMC [(I)2.5(.)]TJ /Span<>> BDC ( )Tj EMC [(A)0.9(c)1.8(h)7.5(k)15.8(a)-3(s)4.9(ov)33.6(, O)-7.4(l)4.8(e)-3.5(g)]TJ /Span<>> BDC ( )Tj EMC [(I)2.4(.)]TJ /Span<>> BDC ( )Tj EMC [(S)15.9(us)9.6(h)7.5(k)12.9(o)-0.6(v)]TJ /T1_3 1 Tf 0.023 Tw -3.238 -2.436 Td (\255\026\036\031\036\025\034\224 \017\225 \032\026\020\017\022\032\221 \(\ ORCID\))Tj /T1_1 1 Tf 0 Tw T* (\202\004\022\026\f\024\r \221.\222.)Tj /Span<>> BDC ( )Tj EMC (\227 0000-0001-9294-5447)Tj T* (\204\017\027\020\026\024\r \202.\205.)Tj /Span<>> BDC ( )Tj EMC (\227 0000-0002-4558-560X)Tj T* (\221\031\001\022\024\r \210.\222.)Tj /Span<>> BDC ( )Tj EMC (\227 0000-0001-9780-7916)Tj T* (\207\026\030\026\027\024\r\026 \230.\202.)Tj /Span<>> BDC ( )Tj EMC (\227 0000-0003-2013-8798)Tj T* (\025\026\035\026\027\024\r \207.\217.)Tj /Span<>> BDC ( )Tj EMC (\227 0009-0001-4679-5756)Tj /T1_3 1 Tf 0.023 Tw 0 -2.436 TD (INFORMATION ABOUT THE AUTHORS \(ORCID\))Tj /T1_1 1 Tf 0 Tw 0 -1.218 TD [(Ser)-32(ge)-11(y I. A)-24.9(chk)-17(asov)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0001-9294-5447)Tj T* [(Air)-33(a)15(t F. Minga)-23.9(zov)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0002-4558-560X)Tj T* (Oleg I. Sushkov)Tj /Span<>> BDC ( )Tj EMC (\227 0000-0001-9780-7916)Tj T* [(T)40(a)15(t)-32(iana A. Bar)-32.9(anov)-15(a)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0003-2013-8798)Tj T* [(Bul)-16(a)15(t R. K)-15.9(al)-16(anov)]TJ /Span<>> BDC ( )Tj EMC (\227 0009-0001-4679-5756)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 42.5896 249.8879 Tm [(\r\031\024\034\033)48(\026)45(\024)-10(\223\033)48(\026/REFERENCES)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0 Tc -0.028 Tw 8 0 0 8 42.5197 237.0532 Tm (1.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (\234\036\035\t\020\017\027 \236.\202., \222\r\026\001\022\017\027 \200.\230\ ., \207\036\035\024\031\f\024\r\026 \213.\202., \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. \247\r\036\027\027\t\005 )Tj 0.011 Tc 0.409 Tw -1.296 -1.25 Td (\022\024\035\017\021 \(\02551\), \r\030\024\f\035\t\036. )Tj /T1_4 1 Tf -0.011 Tw (\222\n\023\n\033\032\n\013\024\n\023\n\202\025\002.)Tj /T1_1 1 Tf 0.409 Tw [( 2023;22\(1\):10\22644.)11( )]TJ 0.018 Tc -0.018 Tw 0 -1.25 TD [(d)-15.8(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 2.562 0 Td (10.33878/2073-7556-2023-22-1-10-44)Tj 0 0 0 1 k /GS1 gs 0.649 Tw [( )0.5(/ )0.5(S)-15.9(hel)35.2(ygin )0.5(Y.A.,)18( )]TJ 0 Tc 0.081 Tw -2.562 -1.25 Td [(Iv)-15(ashk)-16(in V.T., Bel)30(ousov)-15(a E.A., e)-11.9(t al. Ul)16(cer)-33(a)15(t)-32(i)-15.9(ve col)-31(i)-23.9(t)-32(is \(K51\), adul)56(ts. )]TJ /T1_4 1 Tf 0 Tw T* [(K)18(olop)46(roktologia.)]TJ /T1_1 1 Tf 0.039 Tw [( 2023;22\(1\):10\22644. \(in Russ.\). )0.5(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.33878/2073-)Tj T* (7556-2023-22-1-10-44.)Tj 0 0 0 1 k /GS1 gs 0.26 Tw T* (2.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Zhao M, e)-12(t al. T)47(he Bur)-24(den of Infl)-16(amma)15(t)17(or)-24(y Bo)-14(wel Disease in )]TJ 0.023 Tw -1.296 -1.25 Td [(Eur)-32(ope in 2020. )]TJ /T1_4 1 Tf [(Jour)-14(nal of Crohn\242s & Colitis.)]TJ /T1_1 1 Tf ( 2021;9\(15\):1573\2261587)Tj 0.211 Tw T* (3.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Bur)-37(isch J, e)-12(t al. Heal)56(t)-13(h-car)-23.9(e costs of infl)-15.9(amma)15(t)17(or)-24(y bo)-14(wel dis)]TJ 0 Tw (-)Tj 0.229 Tw -1.296 -1.25 Td [(ease )0.6(in )0.6(a )0.5(p)32(an-Eur)-31.9(opean, )0.5(communi)-23.9(t)-10(y-based, )0.6(incept)-32(ion )0.6(cohor)-22(t )0.6(dur)]TJ 0 Tw 27.286 0 Td (-)Tj 0.271 Tw -27.286 -1.25 Td [(ing 5 )0.5(year)-10(s of foll)30.1(o)-14(w-up: )0.5(a popul)-16(a)15(t)-32(ion-based )0.5(stud)17(y. )]TJ /T1_4 1 Tf 22.889 0 Td (The Lancet. )Tj /T1_1 1 Tf 0.023 Tw -22.889 -1.25 Td [(Gastr)-32(oenter)-31.9(ol)30(o)-16(g)16(y & Hep)32(a)15.1(t)17(ol)30(o)-16(g)16(y. 2020;5\(5\):454\226464.)]TJ 0.325 Tw T* (4.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Er)-32(onen H, e)-12(t al. L)35(ong-ter)-15.9(m outcome of p)32(a)15(t)-32(ients wi)-24(t)-12.9(h a)-17(cute )]TJ 0.158 Tw -1.296 -1.25 Td [(ul)16(cer)-33(a)15.1(t)-32(i)-16(ve col)-30.9(i)-24(t)-32(is af)-28(ter f)-28(ir)-9.9(st cour)-10(se of intr)-33(avenous cor)-22(t)-31.9(icoster)-32(oids. )]TJ /T1_4 1 Tf 0.023 Tw T* [(Scandinavian Jour)-14(nal of Gastroenterology.)]TJ /T1_1 1 Tf ( 2021;3\(56\):234\226238.)Tj 0.217 Tw T* (5.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(F)10(est)15(a )0.6(S, )0.5(e)-12(t )0.5(al. )0.6(L)35(ong-ter)-16(m )0.6(outcomes )0.6(of )0.5(a)-17(cute )0.6(sever)-24(e )0.6(ul)16(cer)-33(a)15(t)-32(i)-16(ve )]TJ 0.019 Tw 27.759 18.75 Td [(col)-31(i)-23.9(t)-32(is in t)-13(he r)-24(escue t)-12.9(her)-33(apy er)-33(a: A mul)56(t)-32(icentr)-23.9(e cohor)-21.9(t stud)17.1(y. U)12.9(ni)-23.9(ted )]TJ /T1_4 1 Tf 0.023 Tw T* [(European Gastroenterology Jour)-13.9(nal.)]TJ /T1_1 1 Tf ( 2021;4\(9\):507\226516.)Tj 0.045 Tw T* (6.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(W)-16(ill)-30.9(iams JG, e)-12(t al. Infl)-31(iximab ver)-10(sus c)-23.9(icl)30(ospor)-37(in for ster)-32(oid-r)-23.9(esis)]TJ 0 Tw (-)Tj 0.063 Tw -1.296 -1.25 Td [(t)15(ant a)-17(cute sever)-23.9(e ul)16(cer)-33(a)15.1(t)-32(i)-16(ve col)-31(i)-23.9(t)-32(is \(C)13(ONS)-21(TR)12(UCT\): a mix)12(ed me)-12(t)-13(hods, )]TJ -0.031 Tw T* [(open-l)-16(abel, p)24.9(r)-32.9(a)-17(gma)15(t)-32(ic r)-33(and)-16(omised tr)-37(ial. )]TJ /T1_4 1 Tf (The Lancet. )Tj /T1_1 1 Tf 0 Tw [(Gastr)-32(oenter)-31.9(ol)30(o)-16(g)16(y )]TJ 0.023 Tw T* [(& Hep)32(a)15(t)17(ol)30.1(o)-16(g)16(y. 2016;1\(1\):15\22624.)]TJ 0.254 Tw T* (7.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(L)35(eeds IL, e)-12(t al. Outcomes for Ul)16(cer)-32.9(a)15(t)-32(i)-16(ve Col)-31(i)-24(t)-32(is W)-16(i)-23.9(t)-13(h Del)-15.9(a)15(yed )]TJ 0.106 Tw -1.296 -1.25 Td [(Emer)-32(gency Colec)-16(t)17(omy Ar)-23.9(e W)20(or)-10(se When Contr)-32(oll)-31(ing for P)35(r)-24(eoper)-32.9(a)15(t)-32(i)-16(ve )]TJ 0.023 Tw T* [(R)-24(isk F)20(a)-17.1(c)-15.9(t)17(or)-10(s. )]TJ /T1_4 1 Tf [(Diseases of the Colon & R)21(ectum. )]TJ /T1_1 1 Tf 0 Tw (2019;5\(62\):600\226607.)Tj 0.038 Tw T* (8.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(L)-32(iber)-32.9(a)15(t)-32(i A, e)-12(t al. T)47(he PRISMA S)15(t)15(a)15.1(tement for R)13(epor)-22(t)-31.9(ing Sy)-13(stema)15(t)-32(ic )]TJ 0.256 Tw -1.296 -1.25 Td [(R)13(ev)-16(iews and Me)-12(t)15(a-Anal)35.1(y)-13(ses of S)15(tudies T)47(ha)15(t Ev)-15(al)35(ua)15(te Heal)56(t)-13(h Car)-23.9(e )]TJ 0.117 Tw T* [(Inter)-32(vent)-31.9(ions: )0.5(E)35(xpl)-16(ana)15(t)-32(ion )0.5(and )0.5(El)-16(abor)-32.9(a)15(t)-32(ion. )]TJ /T1_4 1 Tf 18.512 0 Td [(PLoS )0.5(Medicine.)]TJ /T1_1 1 Tf [( )0.5(2009;7 )]TJ 0 Tw -18.512 -1.25 Td (\(6\):e1000100.)Tj 0.271 Tw T* (9.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Han W, e)-12(t al. Ear)-30(l)35(y p)25(r)-24(edic)-16(t)17.1(or)-10(s of r)-24(esponses and cl)-31(inical out)]TJ 0 Tw (-)Tj 0.332 Tw -1.296 -1.25 Td [(comes of cor)-22(t)-31.9(icoster)-32(oid tr)-24(ea)15(tment )0.5(for sever)-24(e ul)16(cer)-32.9(a)15(t)-32(i)-16(ve col)-30.9(i)-24(t)-32(is. )]TJ /T1_4 1 Tf 0.023 Tw T* [(Scandinavian Jour)-14(nal of Gastroenterology.)]TJ /T1_1 1 Tf ( 2014;4\(49\):424\226433.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 0 Tw 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\214)10(\211\036\033 \035\030\032\t\033)30(\b)42(\032)-21(\240\033\233)]TJ 57.136 0 Td (REVIEW)Tj /T1_5 1 Tf 25 0 0 25 505.5644 56.0378 Tm (179)Tj ET endstream endobj 249 0 obj <>/Border[0 0 0]/H/N/Rect[63.015 224.349 194.681 215.053]/Subtype/Link/Type/Annot>> endobj 250 0 obj <>/Border[0 0 0]/H/N/Rect[210.894 204.349 263.622 194.893]/Subtype/Link/Type/Annot>> endobj 251 0 obj <>/Border[0 0 0]/H/N/Rect[42.5197 194.349 118.967 185.053]/Subtype/Link/Type/Annot>> endobj 254 0 obj <> endobj 253 0 obj <> endobj 252 0 obj <> endobj 238 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.108 Tw 10 0 0 10 70.8661 724.8299 Tm (\031)Tj /Span<>> BDC ( )Tj EMC 0.785 0 Td [(\023\026\006\017\036\027\021\024\r )0.6(\f)]TJ /Span<>> BDC ( )Tj EMC 5.44 0 Td [(\021\016\032\036\035\t\n )0.6(\247\025, )0.6(\023\024)]TJ /Span<>> BDC ( )Tj EMC 6.977 0 Td [(\r\f\036\005 )0.6(\r\017\007\017\n\024\f\021\017, )0.6(\f\r\016)]TJ 0 Tw (-)Tj 0.107 Tw -13.202 -1.218 Td (\026\027\024 \f)Tj /Span<>> BDC ( )Tj EMC (\020\036\021\036\030\024\020\036\027\027\024\f\021\034\033 \007\026\027\027\ \t\b. \210\007\027\024\005 \017)Tj /Span<>> BDC ( )Tj EMC (\027\036\n\027\024\020\017\b )Tj 0.028 Tw 0 -1.218 TD [(\023\024\007\024\002\027\t\b \030\026\002\024\021 \016\r\035\016\036\021\ \f\016 \n\036\021\026\026\027\026\035\017 Dias e)-12(t al, \r)]TJ /Span<>> BDC ( )Tj EMC (\022\024)Tj 0 Tw (-)Tj 0.092 Tw T* (\021\024\030\t\005 \002\t\035\024 \r\022\035\033\004\036\027\024 20 \030\ \036\021\030\024\f\023\036\022\021\017\r\027\t\b \017\f\f\035\036\007\024\ )Tj 0 Tw (-)Tj 0.09 Tw T* (\r\026\027\017\005, \024\023\031\002\035\017\022\024\r\026\027\027\t\b \r\ )Tj /Span<>> BDC ( )Tj EMC (\023\036\030\017\024\007 \f)Tj /Span<>> BDC ( )Tj EMC (1988 \023\024)Tj /Span<>> BDC ( )Tj EMC (2012 \020\020. )Tj 0.317 Tw T* (\210\027 \002\t\035 \023\024\f\r\016\013\036\027 \035\017\001\034 \f\030\ \026\r\027\036\027\017\033 \b\026\030\026\022\021\036\030\017\f\021\017\022\ )Tj 0.016 Tw 0 -1.218 TD (\023\026\006\017\036\027\021\024\r \r)Tj /Span<>> BDC ( )Tj EMC (\022\026\004\036\f\021\r\036 \023\030\036\007\017\022\021\024\030\024\r \ \027\036\220\235\235\036\022\021\017\r\027\024\f\021\017 )Tj 0.078 Tw 0 -1.218 TD [(\022\024\027\f\036\030\r\026\021\017\r\027\024\005 )0.6(\021\036\030\026\023\017\017. )0.5(\202\r\021\024\030\t )0.6(\024\021\n\036\021\017\035\017, )0.5(\004\021\024 )0.6(\024\006\036)]TJ 0 Tw (-)Tj 0.323 Tw T* (\027\017\021\034 \035\026\002\024\030\026\021\024\030\027\t\036 \023\024\ \022\026\026\021\036\035\017 \027\036 \023\030\036\007\f\021\026\r\035\016\ \035\024\f\034 )Tj 0.302 Tw T* (\r\024\n\024\032\027\t\n \r)Tj /Span<>> BDC ( )Tj EMC (\r\017\007\031 \030\036\022\024\005 \020\036\021\036\030\024\020\036\027\ \027\024\f\021\017. \210\007\027\017\n )Tj 0.317 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC 1.494 0 Td [(\023\030\036\007\017\022\021\024\030\024\r )0.5(\027\036\220\235\235\036\022\021\017\r\027\024\f\021\017 )0.7(\021\036\030\026\023\017\017 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 18.721 0 Td (\220\021\024\n )Tj 0.115 Tw -20.215 -1.218 Td (\024\002\024\030\036 \002\t\035\024 \024\023\030\036\007\036\035\036\027\ \024 \021\024\021\026\035\034\027\024\036 \023\024\030\026\032\036\027\017\ \036 \f\035\017)Tj 0 Tw (-)Tj 0.005 Tw 0 -1.218 TD [(\017\f\021\024\005 )0.5(\024\002\024\035\024\004\022\017 )0.6(\021\024\035\f\021\024\005 )0.5(\022\017\001\022\017 )0.5([29]. )0.5(\215\030\024\021\016\032\036\027\027\024\f\021\034 )]TJ 0.681 Tw 0 -1.218 TD [(\023\024\030\026\032\036\027\017\016, \027\026\030\016\007\031 )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC (\r\t\030\026\032\036\027\027\024\f\021\034\033 \r\024\f\023\026\035\017)Tj 0 Tw (-)Tj 0.362 Tw 0 -1.218 TD (\021\036\035\034\027\t\b \017\n\036\027\036\027\017\005, \016\r\035\016\ \036\021\f\016 \027\026\017\002\024\035\036\036 \027\026\004\017\n\t\n \ )Tj 0.341 Tw T* (\235\026\022\021\024\030\024\n \030\026\r\017\021\017\016 \020\024\030\n\ \024\027\026\035\034\027\024\005 \030\036\017\f\021\036\027\021\027\024\ \f\021\017. )Tj 0.126 Tw T* (\215\030\024\r\036\007\036\027\027\t\005 \027\026\n\017 \n\036\021\026\026\ \027\026\035\017 \021\026\022\032\036 \023\024\007\021\r\036\030\032\007\ \026\036\021 )Tj -0.036 Tw T* (\023\030\024\020\027\024\f\021\017\004\036\f\022\031\033 \006\036\027\027\ \024\f\021\034 \235\026\022\021\026 \021\024\021\026\035\034\027\024\020\ \024 \023\024\030\026\032\036)Tj 0 Tw (-)Tj 0.136 Tw T* (\027\017\016 \027\026)Tj /Span<>> BDC ( )Tj EMC (\017\f\b\024\007\t \035\036\004\036\027\017\016 \(\210\234)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (1,5; 95% \212\222: 1,1\2262\). )Tj 0.162 Tw T* [(\210\007\027\026\022\024 )0.5(\020\035\026\r\027\t\n )0.6(\024\020\030\026\027\017\004\036\027\017\036\n )0.6(\220\021\024\020\024 )0.5(\023\026\030\026\n\036\021\030\026 )0.6(\016\r)]TJ 0 Tw (-)Tj 0.074 Tw T* [(\035\016\036\021\f\016 )0.5(\021\024, \004\021\024 \024\006\036\027\017\021\034 )0.5(\023\030\024\021\016\032\036\027\027\024\f\021\034 )0.5(\023\024\030\026\032\036\027\017\016 )0.5(\027\036 )]TJ 0.017 Tw T* (\r\f\036\020\007\026 \023\030\036\007\f\021\026\r\035\016\036\021\f\016 \ \r\024\n\024\032\027\t\n, \024\f\024\002\036\027\027\024 \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017)Tj 0 Tw (-)Tj -0.033 Tw T* (\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\024\f\021\030\t\n \021\016\032\036\035\t\n \247\025, \004\021\024 \027\036\ \024\002\035\036\020\004\026\036\021 \023\030\024\006\036\f\f )Tj 0 Tw T* (\023\030\017\027\016\021\017\016 \030\036\001\036\027\017\016.)Tj 0.016 Tw T* (\200 \f\r\016\017 \f)Tj /Span<>> BDC ( )Tj EMC (\220\021\017\n, \r)Tj /Span<>> BDC ( )Tj EMC (\f\017\f\021\036\n\026\021\017\004\036\f\022\024\n \024\002\024\030\036\ \027\026\004\017\021\036\035\034)Tj 0 Tw (-)Tj 0.181 Tw T* (\027\024\036 \r\027\017\n\026\027\017\036 \031\007\036\035\036\027\024 \026\ \027\026\035\017\031 \r\035\017\016\027\017\016 \030\026\035\017\004\027\ \t\b )Tj 0.161 Tw T* (\035\026\002\024\030\026\021\024\030\027\t\b \023\026\030\026\n\036\021\030\ \024\r. \210\007\027\017\n \017)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\017\b \023\030\036\007\017\022)Tj 0 Tw (-)Tj 0.265 Tw T* (\021\024\030\024\r \016\r\035\016\036\021\f\016 \031\030\024\r\036\027\034\ \026\035\034\002\031\n\017\027\026 \023\036\030\036\007 \027\026\004\026\ \035\024\n )Tj 0.125 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\r\024 \r\030\036\n\016 \023\030\024\r\036\007\036\027\017\016 \020\024\030\ \n\024\027\026\035\034\027\024\005 \021\036\030\026\023\017\017. \230\026\ \022, )Tj -0.008 Tw T* (\023\024)Tj /Span<>> BDC ( )Tj EMC (\030\036\031\035\034\021\026\021\026\n \n\036\021\026\026\027\026\035\017\ \026, \031\030\024\r\036\027\034 \026\035\034\002\031\n\017\027\026 \023\ \030\024)Tj 0 Tw (-)Tj 0.432 Tw T* (\007\036\n\024\027\f\021\030\017\030\024\r\026\035 \f\021\026\021\017\f\021\ \017\004\036\f\022\017 \027\026\004\017\n\031\033 \030\026\027\017\006\ \031 )Tj 0.181 Tw T* (\n\036\032\007\031 \020\030\031\023\023\026\n\017 \027\026)Tj /Span<>> BDC ( )Tj EMC (\n\024\n\036\027\021 \027\026\004\026\035\026 \022\024\027\f\036\030\r\026\ \021\017\r\027\024\005 )Tj 0.163 Tw T* (\021\036\030\026\023\017\017 \(\030\026\027\017\006\026 \f\030\036\007\027\ \017\b)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC 0 Tw (\257)Tj 0.163 Tw (4,1; 95% \212\222: )Tj 0 Tw (\257)Tj 0.163 Tw (4,5)Tj /Span<>> BDC ( )Tj EMC (\227 )Tj 0 Tw T* (\257)Tj 0.135 Tw (3,7\). \221\023\031\f\021\016 3 \f\031\021\024\022 \(\030\026\027\017\006\ \026 \f\030\036\007\027\017\b)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC 0 Tw (\257)Tj 0.135 Tw (4,3; 95% )Tj 0 Tw T* (\212\222: )Tj 1.794 0 Td (\257)Tj 0.043 Tw (5,5)Tj /Span<>> BDC ( )Tj EMC (\227 )Tj 0 Tw (\257)Tj 0.043 Tw (3,2\) \024\027 \002\t\035 \021\026\022\032\036 \f\021\026\021\017\f\021\017\ \004\036\f\022\017 \027\026\004\017)Tj 0 Tw (-)Tj -0.031 Tw -1.794 -1.218 Td [(\n\024 )0.5(\027\017\032\036 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 4.303 0 Td [(\020\030\031\023\023\036 )0.5(\027\036\002\035\026\020\024\023\030\017\016\021\027\024\020\024 )0.5(\017\f\b\024\007\026. )0.6(\215\030\017)]TJ /Span<>> BDC ( )Tj EMC 15.912 0 Td (\220\021\024\n )Tj 0.295 Tw -20.215 -1.218 Td [(\023\024\022\026\026\021\036\035\034 )0.6(\020\036\021\036\030\024\020\036\027\027\024\f\021\017 )0.5(\030\036\031\035\034\021\026\021\024\r )0.6(\017\f\f\035\036\007\024\r\026)]TJ 0 Tw (-)Tj -0.039 Tw T* (\027\017\005, \r\022\035\033\004\036\027\027\t\b \r)Tj /Span<>> BDC ( )Tj EMC (\n\036\021\026\026\027\026\035\017, \f\024\f\021\026\r\017\035 66%. \203\ \024)Tj /Span<>> BDC ( )Tj EMC (\f\021\024)Tj 0 Tw (-)Tj 0.149 Tw T* (\017\021 \024\021\n\036\021\017\021\034, \004\021\024 \027\026)Tj /Span<>> BDC ( )Tj EMC (3 \f\031\021\022\017 \021\036\030\026\023\017\017 \020\036\021\036\030\024\ \020\036\027\027\024\f\021\034 )Tj 0.007 Tw T* (\027\026\004\036\027\017\005 \026\035\034\002\031\n\017\027\026 \023\024\ \035\027\024\f\021\034\033 \027\017\r\036\035\017\030\031\036\021\f\016 \ \007\024)Tj /Span<>> BDC ( )Tj EMC (0%. )Tj 0.056 Tw T* (\212\017\026\020\027\024\f\021\017\004\036\f\022\026\016 \006\036\027\027\ \024\f\021\034 \026\035\034\002\031\n\017\027\026, \022\026\022 \023\030\ \036\007\017\022\021\024)Tj 0 Tw (-)Tj 0.405 Tw T* (\030\026 \020\024\030\n\024\027\026\035\034\027\024\005 \030\036\017\f\021\ \036\027\021\027\024\f\021\017, \023\024\007\021\r\036\030\032\007\026\035\ \026\f\034 )Tj 0.218 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\r \007\030\031\020\017\b \017\f\f\035\036\007\024\r\026\027\017\016\b, \ \027\036 \r\022\035\033\004\036\027\027\t\b \r)Tj /Span<>> BDC ( )Tj EMC (\n\036\021\026)Tj 0 Tw (-)Tj 0.132 Tw T* (\026\027\026\035\017 \017-\026 \027\036\f\024\024\021\r\036\021\f\021\ \r\017\016 \022\030\017\021\036\030\017\016\n \r\022\035\033\004\036\027\ \017\016. )Tj -0.009 Tw T* (\203\026\023\030\017\n\036\030, \r)Tj /Span<>> BDC ( )Tj EMC [(\024\002\f\036\030\r\026\006\017\024\027\027\024\n \017\f\f\035\036\007\024\ \r\026\027\017\017 L)35(ee e)-12(t al. )]TJ 0.408 Tw T* (\002\t\035\026 \023\030\024\007\036\n\024\027\f\021\030\017\030\024\r\026\ \027\026 \023\030\017\004\017\027\027\024-\f\035\036\007\f\021\r\036\027\ \027\026\016 )Tj 0.136 Tw T* (\f\r\016\034 \020\017\023\024\026\035\034\002\031\n\017\027\036\n\017\017\ \r)Tj /Span<>> BDC ( )Tj EMC (\b\024\007\036 \f\021\026\027\007\026\030\021\027\024\020\024 \035\036\004\ \036)Tj 0 Tw (-)Tj 0.069 Tw T* (\027\017\016 \022\024\030\021\017\022\024\f\021\036\030\024\017\007\026\n\ \017 \f)Tj /Span<>> BDC ( )Tj EMC (\027\036\220\235\235\036\022\021\017\r\027\024\f\021\034\033 \020\024\030\ \n\024)Tj 0 Tw (-)Tj T* (\027\026\035\034\027\024\005 \021\036\030\026\023\017\017 [30].)Tj -0.023 Tw T* [(\202\027\026\035\024\020\017\004\027\024 )0.5(\031\030\024\r\027\033 \026\035\034\002\031\n\017\027\026, )0.5(\021\016\032\036\f\021\034 \r\024\f\023\026\035\017\021\036\035\034)]TJ 0 Tw (-)Tj -0.045 Tw T* (\027\t\b \017\n\036\027\036\027\017\005 \022\024\030\030\036\035\017\030\ \031\036\021 \f)Tj /Span<>> BDC ( )Tj EMC (\031\030\024\r\027\036\n \221-\030\036\026\022\021\017\r\027\024\020\024\ )Tj 0.2 Tw T* (\002\036\035\022\026, \022\024\021\024\030\t\005 \016\r\035\016\036\021\f\ \016 \031\007\024\002\027\t\n \023\024\022\026\026\021\036\035\036\n \007\ \035\016 )Tj 0.307 Tw T* (\n\024\027\017\021\024\030\017\027\020\026 \220\235\235\036\022\021\017\r\ \027\024\f\021\017 \023\030\024\r\024\007\017\n\024\005 \021\036\030\026\ \023\017\017. )Tj -0.076 Tw T* (\200)Tj /Span<>> BDC ( )Tj EMC (\023\024\f\035\036\007\027\036\036 \r\030\036\n\016 \027\036\022\024\021\ \024\030\t\n\017 \026\r\021\024\030\026\n\017 \023\030\036\007\035\024\032\ \036\027\024 )Tj 0.53 Tw 23.244 64.543 Td (\030\026\f\f\004\017\021\t\r\026\021\034 \f\024\024\021\027\024\001\036\027\ \017\036 \221-\030\036\026\022\021\017\r\027\024\020\024 \002\036\035\022\ \026/)Tj 0.113 Tw T* [(\026\035\034\002\031\n\017\027\026 \(C)20(AR\). \230\026\022, \030\026\002\024\021\026 Gibson e)-12(t al, \r\022\035\033\004\036\027)]TJ 0 Tw (-)Tj 0.264 Tw T* (\027\026\016 \r)Tj /Span<>> BDC ( )Tj EMC (\027\026\001 \n\036\021\026\026\027\026\035\017, \023\030\024\007\036\n\ \024\027\f\021\030\017\030\024\r\026\035\026 \r\t\f\024)Tj 0 Tw (-)Tj 0.307 Tw T* (\022\031\033 \023\030\024\020)Tj /Span<>> BDC ( )Tj EMC 3.994 0 Td (\027\024\f\021\017\004\036\f\022\031\033 \006\036\027\027\024\f\021\034 \ \f\024\024\021\027\024\001\036\027\017\016 \221\217\207/)Tj 0.105 Tw -3.994 -1.218 Td (\026\035\034\002\031\n\017\027 \027\026)Tj /Span<>> BDC ( )Tj EMC (3 \f\031\021\022\017 \023\030\024\r\024\007\017\n\024\005 \021\036\030\026\ \023\017\017. \215\030\017)Tj /Span<>> BDC ( )Tj EMC (\027\026)Tj 0 Tw (-)Tj 0.172 Tw T* [(\004\036\027\017\017 C)20(AR \002\024\035\036\036 0,85 \(\023\035\024\013\026\007\034 \023\024\007\ \022\030\017\r\024\005)]TJ /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,75, )Tj /T1_1 1 Tf 0 Tw 0 -1.218 TD (p)Tj /T1_0 1 Tf 0.316 Tw /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (0,0001\), \024\021\027\024\f\017\021\036\035\034\027\t\005 \030\017\f\022\ \022\024\035\220\022\021\024\n\017\017 \002\t\035 )Tj 0.007 Tw 0 -1.218 TD (\r\t\001\036 \023\024\004\021\017 \r)Tj /Span<>> BDC ( )Tj EMC (4 \030\026\026 \(\210\217)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (3,9; 95% \212\222: 2,1\2267,2\) [11]. )Tj 0.053 Tw T* [(\207\024\035\036\036 \021\024\020\024, \024\002\f\036\030\r\026\006\017\024\ \027\027\024\036 \017\f\f\035\036\007\024\r\026\027\017\036 Header e)-12(t )]TJ 0.083 Tw T* (al. \023\024\022\026\026\035\024 \023\030\017\n\036\027\017\n\024\f\021\ \034 \f\024\024\021\027\024\001\036\027\017\016 \221\217\207/\026\035\034\ \002\031)Tj 0 Tw (-)Tj 0.029 Tw T* (\n\017\027 \r)Tj /Span<>> BDC ( )Tj EMC 2.597 0 Td [(\024\021\027\024\001\036\027\017\017 \f\021\030\026\021\017\235\017\022\026\ \006\017\017 )0.5(\023\026\006\017\036\027\021\024\r )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\031 )Tj 0.247 Tw -2.597 -1.218 Td [(\r\t\f\024\022\024\020\024 \030\017\f\022\026 \027\036\002\035\026\020\024\ \023\030\017\016\021\027\t\b )0.5(\017\f\b\024\007\024\r \021\036\030\026\023\017\017 )]TJ 0 Tw 0 -1.218 TD (\(\023\035\024\013\026\007\034 \023\024\007 \022\030\017\r\024\005)Tj /Span<>> BDC ( )Tj EMC (\227 0,98, )Tj /T1_1 1 Tf (p)Tj /T1_0 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,001\) [31].)Tj 0.183 Tw 0 -1.218 TD (\210\021\007\036\035\034\027\024\020\024 \r\027\017\n\026\027\017\016 \021\ \030\036\002\031\036\021 \024\006\036\027\022\026 \220\027\007\024\f\022\ \024\023\017\004\036)Tj 0 Tw (-)Tj -0.03 Tw 0 -1.218 TD [(\f\022\024\005 \022\026\030\021\017\027\t )0.5(\f\035\017\017\f\021\024\005 )0.5(\024\002\024\035\024\004\022\017 \021\024\035\f\021\024\005 )0.5(\022\017\001\022\017, )0.5(\022\026\022 )]TJ 0.003 Tw T* [(\024\f\027\024\r\027\024\020\024 \022\030\017\021\036\030\017\016, )0.5(\022\024\021\024\030\t\005 \027\036\024\002\b\024\007\017\n\024 \031\004\ \017\021\t\r\026\021\034, )]TJ 0.079 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\r\031\033 \024\004\036\030\036\007\034, \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\235\024\030\n\017\030\024\r\026\027\017\017 \021\026\022\021\017\022\017\ \035\036\004\036)Tj 0 Tw (-)Tj 0.199 Tw T* (\027\017\016 \023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\021\016\032\036\035\024\005 \026\021\026\022\024\005 \247\025. \200)Tj /Span<>> BDC ( )Tj EMC (\035\017\021\036\030\026\021\031\030\036 )Tj -0.009 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC (\f\036\020\024\007\027\016\001\027\017\005 \007\036\027\034 \024\023\017\ \f\026\027\t 2 \024\f\027\024\r\027\t\036 \001\022\026\035\t \007\035\016\ )Tj 0.249 Tw T* (\024\006\036\027\022\017 \021\016\032\036\f\021\017 \023\024\030\026\032\ \036\027\017\016 \247\025 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\022\024\035\024\027\024\f\022\024\023\017\017: )Tj 0.162 Tw T* (UCEIS \(8 \002\026\035\035\024\r\) \017)Tj /Span<>> BDC ( )Tj EMC (MES \(3 \002\026\035\035\026\) [15]. \203\026)Tj /Span<>> BDC ( )Tj EMC (\023\030\026\022\021\017)Tj 0 Tw (-)Tj 0.353 Tw T* (\022\036, \021\016\032\036\f\021\034 \r\024\f\023\026\035\017\021\036\035\ \034\027\t\b \017\n\036\027\036\027\017\005 \f\035\017\017\f\021\024\005\ )Tj 0.22 Tw T* (\024\002\024\035\024\004\022\017 \021\024\035\f\021\024\005 \022\017\001\ \022\017 \023\030\016\n\024 \022\024\030\030\036\035\017\030\031\036\021\ \f)Tj /Span<>> BDC ( )Tj EMC (\r\t)Tj 0 Tw (-)Tj 0.29 Tw T* (\030\026\032\036\027\027\024\f\021\034\033 \022\035\017\027\017\004\036\f\ \022\024\005 \022\026\030\021\017\027\t \017)Tj /Span<>> BDC ( )Tj EMC (\n\036\021\026\002\024\035\017\004\036)Tj 0 Tw (-)Tj 0.168 Tw T* (\f\022\017\b \027\026\030\031\001\036\027\017\005. \224\021\024\021 \235\ \026\022\021 \022\024\f\r\036\027\027\024 \023\024\007\021\r\036\030\032\ \007\026\036\021 )Tj 0.091 Tw T* [(\017\f\f\035\036\007\024\r\026\027\017\036 Zhang e)-12(t al, \r)]TJ /Span<>> BDC ( )Tj EMC (\022\024\021\024\030\024\n \002\t\035\026 \r\t\016\r\035\036\027\026 )Tj 0.319 Tw T* (\035\017\027\036\005\027\026\016 \r\026\017\n\024\f\r\016\034 \n\036\032\ \007\031 \220\021\017\n\017 \023\024\022\026\026\021\036\035\016\n\017 \ )Tj 0.095 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\027\026\004\036\027\017\036\n \001\022\026\035\t UCEIS \r\t\001\036 7 \ \002\026\035\035\024\r \()Tj /T1_1 1 Tf 0 Tw (r)Tj /T1_0 1 Tf 0.095 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,742, )Tj /T1_1 1 Tf 0 Tw T* (p)Tj /T1_0 1 Tf /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (0,001\) [32].)Tj 0.09 Tw T* (\200 \024\021\036\004\036\f\021\r\036\027\027\024\005 \035\017\021\036\030\ \026\021\031\030\036 \021\026\022\032\036 \026\022\021\017\r\027\024 \024\ \f\r\036\013\036\027 )Tj 0.668 Tw T* (\r\024\023\030\024\f \023\030\024\020\027\024\017\030\024\r\026\027\017\ \016 \027\036\220\235\235\036\022\021\017\r\027\024\f\021\017 \022\024\027\ )Tj 0 Tw (-)Tj 0.258 Tw T* (\f\036\030\r\026\021\017\r\027\024\005 \021\036\030\026\023\017\017 \031\ )Tj /Span<>> BDC ( )Tj EMC (\002\024\035\034\027\t\b \021\016\032\036\035\t\n \247\025. \230\026\022\ , )Tj -0.032 Tw T* (\206\024\035\024\r\036\027\022\024 \202.\210. \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. \002\t\035\026 \030\026\030\026\002\024\021\026\027\026\ \023\030\024\020\027\024\f\021\017)Tj 0 Tw (-)Tj 0.055 Tw T* (\004\036\f\022\026\016 \n\024\007\036\035\034 \007\035\016 \024\023\030\036\ \007\036\035\036\027\017\016 \027\036\024\002\b\024\007\017\n\024\f\021\017\ \022\024\035)Tj 0 Tw (-)Tj -0.017 Tw T* (\220\022\021\024\n\017\017 \031)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\034\027\t\b \f)Tj /Span<>> BDC ( )Tj EMC (\021\016\032\036\035\t\n \247\025, \r\022\035\033\004\026\033\013\026\016\ \r)Tj /Span<>> BDC ( )Tj EMC (\f\036\002\016 )Tj 0.09 Tw T* [(\021\026\022\017\036 )0.5(\023\030\036\007\017\022\021\024\030\t, \022\026\022 \020\017\023\024\026\ \035\034\002\031\n\017\027\036\n\017\016 )0.6(\(<)]TJ /Span<>> BDC ( )Tj EMC (30 \020/\035\) )Tj 0.084 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\027\026\035\017\004\017\036 \253\024\002\001\017\030\027\t\b \016\r\036\ \027\027\t\b \007\036\235\036\022\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\024\002\030\026\024)Tj 0 Tw (-)Tj 0.036 Tw T* [(\r\026\027\017\036\n )0.5(\024\f\021\030\024\r\022\024\r )0.6(\f\035\017\017\f\021\024\005 )0.5(\024\002\024\035\024\004\022\017\273. )0.6(\217\017\f\022 )0.5(\022\024\035\220\022)]TJ 0 Tw (-)Tj 0.056 Tw T* (\021\024\n\017\017 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\f\024\004\036\021\026\027\017\017 \220\021\017\b \235\026\022\021\024\030\ \024\r \f\024\f\021\026\r\035\016\035 100% )Tj -0.051 Tw T* ([33]. \217\026\027\036\036 \027\026\n\017 \002\t\035\026 \023\030\036\007\ \f\021\026\r\035\036\027\026 \023\030\024\020\027\024\f\021\017\004\036\f\ \022\026\016 )Tj 0.126 Tw T* (\n\024\007\036\035\034)Tj /Span<>> BDC ( )Tj EMC (\227 \027\024\n\024\020\030\026\n\n\026 \027\026)Tj /Span<>> BDC ( )Tj EMC (\024\f\027\024\r\026\027\017\017 \030\036\021\030\024\f\023\036\022\021\017\ \r)Tj 0 Tw (-)Tj 0.176 Tw T* (\027\t\b \007\026\027\027\t\b, \r)Tj /Span<>> BDC ( )Tj EMC (\022\024\021\024\030\024\005 \f\024\004\036\021\026\027\017\036 \220\027\ \007\024\f\022\024\023\017\004\036\f\022\024\005 )Tj 0.338 Tw T* (\022\026\030\021\017\027\t \024\002\001\017\030\027\t\b \016\r\036\027\027\ \t\b \007\036\235\036\022\021\024\r, \f\027\017\032\036\027\017\016 )Tj 0.04 Tw T* (\031\030\024\r\027\036\005 \026\035\034\002\031\n\017\027\026)Tj /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (31 \020/\035 \017)Tj /Span<>> BDC ( )Tj EMC (\020\036\n\024\020\035\024\002\017\027\026)Tj /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (107 \020/\035 )Tj 0 Tw T* (\023\030\024\020\027\024\017\030\024\r\026\035\017 100% \030\017\f\022 \ \022\024\035\220\022\021\024\n\017\017 [34].)Tj 0.091 Tw T* (\200\035\017\016\027\017\036 \220\027\007\024\f\022\024\023\017\004\036\f\ \022\024\005 \022\026\030\021\017\027\t \027\026)Tj /Span<>> BDC ( )Tj EMC (\253\023\030\024\020\027\024\017\030\024)Tj 0 Tw (-)Tj 0.057 Tw T* (\r\026\027\017\036\273 \017\f\b\024\007\024\r \035\036\004\036\027\017\016\ \021\026\022\032\036 \023\024\007\021\r\036\030\032\007\036\027\024 \r)Tj /Span<>> BDC ( )Tj EMC (\023\030\024)Tj 0 Tw (-)Tj 0.543 Tw T* (\r\036\007\036\027\027\024\n \027\026\n\017 \n\036\021\026\026\027\026\035\ \017\036. \230\026\022, \n\026\022\f\017\n\026\035\034\027\024\036 )Tj 0.346 Tw T* (\027\026\004\036\027\017\036 \220\027\007\024\f\022\024\023\017\004\036\ \f\022\024\005 \001\022\026\035\t UCEIS, \f\024\024\021\r\036\021)Tj 0 Tw (-)Tj 0.237 Tw T* (\f\021\r\031\033\013\036\036 \253\027\026\035\017\004\017\033 \024\002\001\ \017\030\027\t\b \016\r\036\027\027\t\b \007\036\235\036\022\021\024\r \ )Tj -0.012 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\024\002\030\026\024\r\026\027\017\036\n \024\f\021\030\024\r\022\024\r\ \f\035\017\017\f\021\024\005 \024\002\024\035\024\004\022\017\273, \f\021\ \026)Tj 0 Tw (-)Tj 0.269 Tw T* (\021\017\f\021\017\004\036\f\022\017 \027\026\004\017\n\024 \023\024\r\t\ \001\026\035\024 \r\036\030\024\016\021\027\024\f\021\034 \020\024\030\n\ \024)Tj 0 Tw (-)Tj 0.148 Tw T* [(\027\026\035\034\027\024\005 )0.5(\030\036\017\f\021\036\027\021\027\024\f\021\017 )0.5(\031)]TJ /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\021\016\032\036\035\t\n \247\025 )Tj 0.018 Tw T* (\(\210\234)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (4,5; 95% \212\222: 3,2\2266,5\) \023\030\017)Tj /Span<>> BDC ( )Tj EMC (I)Tj 0 Tw 5.83 0 0 5.83 442.9182 82.7258 Tm (2)Tj 0.018 Tw /Span<>> BDC 10 0 0 10 445.8331 79.3958 Tm ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0%. \200)Tj /Span<>> BDC ( )Tj EMC (\021\024\n \004\017\f\035\036, )Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0 Tw 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\214)10(\211\036\033 \035\030\032\t\033)30(\b)42(\032)-21(\240\033\233)]TJ 57.136 0 Td (REVIEW)Tj -57.136 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 23, \023\0221)69(, 202)69(4)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 23, \023\0221)69(, 202)69(4)]TJ /T1_3 1 Tf 25 0 0 25 20.8526 56.0378 Tm (178)Tj ET endstream endobj 231 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\034\002\016\201\220\n)-9.9(\026)10.9(\025\002\020 \001\016\f\007\013\202)10(\025\221\002\220\205\026\001\025\202)10.1(\025 \220\006\207\025\201\013 \026)11(\016\002\013\221\220\220 )]TJ 0 -1 TD [(\n)10(\025\002\026\220\n)10(\025\006)-9.9(\026)11(\016\002\025\220\201\013\024\220 \215\022\221\013\227\220\016\001\026)11.1(\025\r \006\022\026\205\217\016\007\025\203 \013\026)11(\013\n)10(\025\203 \205\222\r\016\001\001\025\202)10.1(\025 )]TJ T* [(\n)10(\025\007\220\026)11(\013 \(\006\220\006)-10(\026)11(\016\024\013\026\220\017\016\006\n\220\203 \025\f\222\025\002 \220\022\024\ \016\026)11.1(\013\013\001\013\007\220\222\))]TJ 35.009 2 Td [(Pr)31(edictor)20.1(s of adv)12(er)20(se outcomes of ster)20(oids in patients with se)11(v)12(er)31(e )]TJ 3.699 -1 Td [(ulcer)21(ativ)12.1(e colitis \(s)10(y)10(stematic r)31(e)11(vie)11(w and meta-analy)10(ses\))]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0.171 Tw 10 0 0 10 42.5197 724.8299 Tm (3\))Tj /Span<>> BDC [( )-96( )]TJ EMC 1.37 0 Td (\211\030\024\r\036\027\034 \020\036\n\024\020\035\024\002\017\027\026 \023\ \030\017)Tj /Span<>> BDC ( )Tj EMC (\023\024\f\021\031\023\035\036\027\017\017 \r)Tj /Span<>> BDC ( )Tj EMC (\022\035\017\027\017)Tj 0 Tw (-)Tj 0.131 Tw 0 -1.218 TD (\022\031 \024\022\026\026\035\f\016 \027\017\032\036, \r)Tj /Span<>> BDC ( )Tj EMC (\f\030\036\007\027\036\n, \027\026)Tj /Span<>> BDC ( )Tj EMC (8 \020/\035 \(95% \212\222: )Tj 0 Tw T* (\257)Tj 0.332 Tw (10,1)Tj /Span<>> BDC ( )Tj EMC (\227 )Tj 0 Tw 4.314 0 Td (\257)Tj 0.332 Tw (5,8\) \r)Tj /Span<>> BDC ( )Tj EMC 3.658 0 Td [(\020\030\031\023\023\036 )0.5(\027\036\002\035\026\020\024\023\030\017\016\021\027\024\020\024 \017\f)]TJ 0 Tw (-)Tj 0.192 Tw -7.972 -1.218 Td (\b\024\007\026 \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\f\021\026\r\017\035 102,7 \017)Tj /Span<>> BDC ( )Tj EMC (109 \020/\035, \023\024)Tj /Span<>> BDC ( )Tj EMC (\f\030\026\r\027\036\027\017\033 )Tj 0.259 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\024\005 \220\235\235\036\022\021\017\r\027\024\005 \ \020\024\030\n\024\027\026\035\034\027\024\005 \021\036\030\026\023\017\017\ , )Tj /T1_2 1 Tf 0 Tw T* (p)Tj /T1_1 1 Tf 0.029 Tw /Span<>> BDC ( )Tj EMC 0.739 0 Td (=)Tj /Span<>> BDC ( )Tj EMC 0.761 0 Td [(0,00001. )0.5(\206\036\021\036\030\024\020\036\027\027\024\f\021\034 )0.6(\f\021\026\021\017\f\021\017\004\036\f\022\017 )0.6(\027\026\004\017)]TJ 0 Tw (-)Tj -1.501 -1.218 Td (\n\026: \(I)Tj 5.83 0 0 5.83 79.2893 655.0919 Tm (2)Tj 10 0 0 10 82.2043 651.7618 Tm (\))Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (74%, )Tj /T1_2 1 Tf (p)Tj /T1_1 1 Tf /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (0,00001 \(\217\017\f.)Tj /Span<>> BDC ( )Tj EMC (7\).)Tj 0.73 Tw -3.968 -1.218 Td (4\))Tj /Span<>> BDC [( )463( )]TJ EMC 1.37 0 Td (\215\030\024\r\036\007\036\027 \n\036\021\026\026\027\026\035\017 \r\035\ \017\016\027\017\016 \220\027\007\024\f\022\024\023\017\004\036)Tj 0 Tw (-)Tj 0.272 Tw T* (\f\022\024\005 \022\026\030\021\017\027\t \027\026)Tj /Span<>> BDC ( )Tj EMC (\030\026\r\017\021\017\036 \020\024\030\n\024\027\026\035\034\027\024\005\ \030\036\017)Tj 0 Tw (-)Tj 0.36 Tw 0 -1.218 TD [(\f\021\036\027\021\027\024\f\021\017. )0.5(\212\035\016 \220\021\024\020\024 \017\r\035\036\004\036\027\t \022\026\ \021\036\020\024\030\017\026\035\034)]TJ 0 Tw (-)Tj 0.169 Tw 0 -1.218 TD (\027\t\036 \007\026\027\027\t\036)Tj /Span<>> BDC ( )Tj EMC (\227 \027\026\004\036\027\017\016 \220\027\007\024\f\022\024\023\017\004\ \036\f\022\017\b \001\022\026\035 )Tj 0.135 Tw 0 -1.218 TD (UCEIS)Tj /Span<>> BDC ( )Tj EMC (\241)Tj /Span<>> BDC ( )Tj EMC (7)Tj /Span<>> BDC ( )Tj EMC (\002\026\035\035\024\r \(\007\026/\027\036\021\) \017)Tj /Span<>> BDC ( )Tj EMC (MES)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (3 \002\026\035\035\026 \(\007\026/)Tj 0.033 Tw T* (\027\036\021\). \215\030\017)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\n \r\t\016\r\035\036\027\024, \004\021\024 \031\022\026\026\ \027\027\024\036 \027\026\004\036\027\017\036 )Tj -0.053 Tw T* (UCEIS)Tj /Span<>> BDC ( )Tj EMC (\241)Tj /Span<>> BDC ( )Tj EMC (7 \002\026\035\035\024\r \r\f\021\030\036\004\026\035\024\f\034 \020\024\ \030\026\007\024 \004\026\013\036 \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023)Tj 0 Tw (-)Tj 0.512 Tw T* (\023\036 \027\036\220\235\235\036\022\021\017\r\027\024\005 \020\024\030\ \n\024\027\026\035\034\027\024\005 \021\036\030\026\023\017\017)Tj /Span<>> BDC ( )Tj EMC (\227 )Tj -0.069 Tw 0 -1.218 TD (\r)Tj /Span<>> BDC ( )Tj EMC (135)Tj /Span<>> BDC ( )Tj EMC (\(37%\), \023\030\024\021\017\r 99)Tj /Span<>> BDC ( )Tj EMC (\(15%\) \027\026\002\035\033\007\036\027\017\005 \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 )Tj 0.083 Tw 0 -1.218 TD [(\220\235\235\036\022\021\017\r\027\024\005 )0.6(\020\024\030\n\024\027\026\035\034\027\024\005 )0.6(\021\036\030\026\023\017\017, )]TJ /T1_2 1 Tf 0 Tw 15.946 0 Td (p)Tj /T1_1 1 Tf 0.083 Tw /Span<>> BDC ( )Tj EMC 0.793 0 Td (=)Tj /Span<>> BDC ( )Tj EMC 0.815 0 Td (0,00001 )Tj 0.165 Tw 5.689 19.485 Td (\(\210\234)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (4,5; 95% \212\222: 3,2\2266,5\). \206\036\021\036\030\024\020\036\027\027\ \024\f\021\034 \027\036 )Tj 0 Tw 0 -1.218 TD (\r\t\016\r\035\036\027\026: \(I)Tj 5.83 0 0 5.83 340.9097 715.9819 Tm (2)Tj 10 0 0 10 343.8247 712.6519 Tm (\))Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0%, )Tj /T1_2 1 Tf (p)Tj /T1_1 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,6 \(\217\017\f. 8\).)Tj 0.115 Tw -6.886 -1.218 Td (\203\036\024\002\b\024\007\017\n\024 \024\021\n\036\021\017\021\034, \004\ \021\024 \220\027\007\024\f\022\024\023\017\004\036\f\022\026\016 \022\026\ \030\021\017\027\026 )Tj 0.164 Tw 0 -1.218 TD (\023\024)Tj /Span<>> BDC ( )Tj EMC (\001\022\026\035\036 MES)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (3 \002\026\035\035\026 \r\f\021\030\036\004\026\035\026\f\034 \021\026\022\ \032\036 \f\021\026\021\017\f)Tj 0 Tw (-)Tj 0.27 Tw T* (\021\017\004\036\f\022\017 \027\026\004\017\n\024 \004\026\013\036 \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \027\036\002\035\026\020\024\023\030\017\016\021\ \027\024\020\024 )Tj 0.046 Tw T* (\017\f\b\024\007\026, \004\036\n \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \220\235\235\036\022\021\017\r\027\024\005 \021\ \036\030\026\023\017\017 \022\024\030\021\017\022\024)Tj 0 Tw (-)Tj 0.008 Tw T* (\f\021\036\030\024\017\007\024\n)Tj /Span<>> BDC ( )Tj EMC (\227 \r)Tj /Span<>> BDC ( )Tj EMC (116)Tj /Span<>> BDC ( )Tj EMC (\(65%\) \017)Tj /Span<>> BDC ( )Tj EMC (204)Tj /Span<>> BDC ( )Tj EMC [(\(43%\) )0.5(\f\035\031\004\026\036\r, \f\024\024\021)]TJ 0 Tw (-)Tj 0 -1.218 TD (\r\036\021\f\021\r\036\027\027\024, )Tj /T1_2 1 Tf 5.07 0 Td (p)Tj /T1_1 1 Tf 0.051 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,00001 \(\210\234)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (2,9; 95% \212\222: 1,9\2264,3\). )Tj 0.341 Tw -5.07 -1.218 Td (\215\030\017)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\n \020\036\021\036\030\024\020\036\027\027\024\f\021\034 \024\ \022\026\026\035\026\f\034 \f\021\026\021\017\f\021\017\004\036\f\022\017\ )Tj 0 Tw T* (\027\026\004\017\n\026: \(I)Tj 5.83 0 0 5.83 321.9197 618.5578 Tm (2)Tj 10 0 0 10 324.8347 615.2278 Tm (\))Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (76%, )Tj /T1_2 1 Tf (p)Tj /T1_1 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,005 \(\217\017\f.)Tj /Span<>> BDC ( )Tj EMC (9\).)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 275.0305 578.6938 Tm [(\037\036)10(\032\223\212\226\034\022\031\034)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0 Tc 0.278 Tw 10 0 0 10 274.9606 554.3378 Tm (\210\021\027\024\f\017\021\036\035\034\027\024 \n\026\035\024\036 \004\017\ \f\035\024 \024\023\031\002\035\017\022\024\r\026\027\027\t\b \f\017\f\021\ \036)Tj 0 Tw (-)Tj 0.348 Tw 0 -1.218 TD (\n\026\021\017\004\036\f\022\017\b \024\002\024\030\024\r, \023\024\f\r\ \016\013\036\027\027\t\b \017\031\004\036\027\017\033 \023\030\036)Tj 0 Tw (-)Tj 0.039 Tw T* (\007\017\022\021\024\030\024\r \027\036\220\235\235\036\022\021\017\r\027\ \024\f\021\017 \022\024\027\f\036\030\r\026\021\017\r\027\024\005 \021\036\ \030\026\023\017\017 )Tj ET q /GS0 gs 453.5433257 0 0 134.3832076 42.5196986 377.0861279 cm /Im0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 0 Tw 9 0 0 9 42.5197 366.2862 Tm (\022\t\217\210\b\002\220 7.)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf ( \214\032\n\027\031\021\022 \202\031\003\n\202\023\n\005\025\021\026 \027\ )Tj /Span<>> BDC ( )Tj EMC (\202\032\205\033\033\026\004 \033\031\032\031\030 \021\026\006\026\023\n\ \003 \024\031\032\026\033\025\025)Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 0 -1.2 TD [(F)-16(igure 7)124.1(.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf [( Lev)13(el of hemog)13.1(lobin before treatment in g)14.2(roups)]TJ ET q /GS0 gs 453.5432692 0 0 125.2353376 42.519683 219.7468765 cm /Im1 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 9 0 0 9 42.5197 208.9469 Tm (\022\t\217\210\b\002\220 8.)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf ( \230\021\030\n\t\013\n\033\025\006\031\t\013\026\002 \013\026\032\024\025\ \021\026 \033\n)Tj /Span<>> BDC ( )Tj EMC (\001\013\026\023\031 UCEIS)Tj /Span<>> BDC ( )Tj EMC (\247)Tj /Span<>> BDC ( )Tj EMC (7 \005\026\023\023\026 \027)Tj /Span<>> BDC ( )Tj EMC (\202\032\205\033\033\026\004)Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf T* [(F)-16(igure 8.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf [( Endoscop)12(y based on UCEIS scale)]TJ /Span<>> BDC ( )Tj EMC (\247)Tj /Span<>> BDC ( )Tj EMC [(7 points in g)14.4(roups)]TJ ET q /GS0 gs 453.543315 0 0 86.6470823 42.5196823 100.9958301 cm /Im2 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 9 0 0 9 42.5197 90.1959 Tm (\022\t\217\210\b\002\220 9.)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf ( \230\021\030\n\t\013\n\033\025\006\031\t\013\026\002 \013\026\032\024\025\ \021\026 \033\n)Tj /Span<>> BDC ( )Tj EMC (\001\013\026\023\031 MES)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (3 \005\026\023\023\026 \027)Tj /Span<>> BDC ( )Tj EMC (\202\032\205\033\033\026\004)Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf T* [(F)-16(igure 9)32.1(.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf [( Endoscop)12(y based on MES scale)]TJ /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC [(3 points in g)14.2(roups)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\214)10(\211\036\033 \035\030\032\t\033)30(\b)42(\032)-21(\240\033\233)]TJ 57.136 0 Td (REVIEW)Tj /T1_5 1 Tf 25 0 0 25 505.6144 56.0378 Tm (177)Tj ET endstream endobj 235 0 obj <>stream HWoy$RO%V+)kJ&\],'*unX%Q!b\K(w")mk 4=`_'صJJJ7k;bRKޝyϼB8p8pB~7֛JNye3iɼq[f`%T>4Ƙo^gÒ{Zi&5xN:{]ϨIEIQ+Us͢.kXMXp _ e * `2~F5hagNlE u[jI=<䬾i#ZQFg|[x;G, -%6֩ ٝYI0lc`scBN [N {C͍I]y7Tp2qCثʛ(hx4$ $AQh\Xl+I0$xXYFx#@t`3pL_ţlFƋi2w7BBPZP]47bxVu*rZl0P7)25 ed4եRwF %mhιk5ߟuÂ`X+,JIg ӰYÖ8Z%3~_dhYz[b Ij*=),-1WWi>C# 4lsJ-1%~V>x u+ 9^++aρn]lXK꒪pj)/xUL]Q˘AI k쫐@D fWa/zg + 0 lo/Ȣ|aě8 ~n ݨՄmXHt;S0,4,ߨ͚\jO3Zb;̀$Iu`X -KM>J*,}߅w DZkXJ$F5x1{bO| \%/VRr:Y*E4-q44 u dW)-Z~-%~| 9xn0=I f'v'1=܊sǁ8p8p) !O4efܨƴUGf8 i1vɨHݳգ/7,^("/_iQV'񚗿N֢yYhf1D_ZTHag_wK @vfDz3vr45f7%lkjk䛯ZWߋ\I@aE4Y#"(< 'z}_5qEL#Ʒr  >U֏t߮I}SU9|ue,{p٧2ܣ,uM;piGF;һw`w6΢`Q:z XW$*h O`Qp2V.D~{Cv3Rޥ<PNּeu ~x !5:P=d1 ޚ#X\ߕN% [ԥ>EYiaXb{v\U(nm;\l*,~CwQc~1|K?)XlQxO)_e&+,'aZaw*Rbn`[ި  6E^} wB$X]!XߗWXS[=11,"{`d/WW.m?WHǸ˂"LMCIQgGcscm=<Kd:XEB`e#N/׶,++}wj*owI4 ,G7"֣U0.ۭ;TQ9go/߼쨻˯sx7? FkE$1~>}>3b)x}umV..{ ["ށ}!6gQ|U%fJ\gc7, w0%a`;lb`J#$]']W:氓 XƫsZ9{u{|R0a/}zhk EGuӃ V !X_숬^{7/'&UX%A~^vO;5|cƯ\{ˏћ <{Va(Ls|>˭%" ,r3 Ίa.!Z?. /{±џ3Dx  `PtPP` 2BlAAF(-(9 -Њ%R erا*f*iNMxUq]wq3pSj@q!+Z}ΞVbIYgxdE(\ſ`Z4 ,kcms&Mfy>e#qxmqA#Y0m',3u`U*FrVIҫJ}F͓;,81ˉS̓`jPX1c,&K)J<ӉBVI,Ǽ%,h,ԵoAU߱@[,{ZȊ*X:jHi Ӯϩk+McGj`GT8znG1a#dEV!z'WK[feT`;+X;a1* ;_@' i9qU0% v0اoؘ ;SRuI=ȹ$X'. +DHE vؙL*9' s<\%Lklͯ5—7M;)&QD oNy GbYuA)g :` 2BlAAF(-(E!Sڹ-Dŏ!&’j/BH^e+5^#\on_N Ԧ ʚA-im28}P Dǘ@cwIn F$r!0:u7A@z|PID7+L˚zɺ?R  IŅ'ݖޕHf,XmF,d&Xk 5N(ǯ}@z/ @&d˴! _01Ui͈-.$ƘNۄ,Gev)1ڌgi.iU<%DKܾ`uJd*X(ebuE2qjL<7 y+l4vں`!!Mv3VN꟮`IeZ v&Ђ !"~`@K Vl,+ !H?W%фTR gM)n&"ʲR䊘?sW]YJ.m]I AVW,[99rlh` OΔ3gE #d"؂`PJ4q 2„VhFdSZ  *C AܩXcA<5 :ir Zp;9V\N"r=YH/Ln,1u:rb$BcؖI#iAM9EjУkiK%| ~_\80i6`"4,%!_ $BKd0vI! |^BQhk69 ɍn&JŅYHB]@g'XF Vs˫.86=C̷>Yz(XwSuS^Y vNQAibKZ:ct5U,BZthƹRa LV}X4+Y`[Ƥ4% Ǝ4% sM'l҇N{""n φ F}.X"@It`g;z i[$+L=c`-qCLEFa&Ĺb71@Ez1ob*~I'bx֖lr?^ VV7W=\g9ʁa` ^=O?)g :` 2BlAAF(-(E!CBiE(iI 2e`6[5Ņx,ݦ`xN}J$P$ X44 #<@c+X fC6 Y VWXh'kc@)K0 [ SmdJƧz?Ղ: Ci;hQٙ6~X|%ۀi>⏄p_y#@#_WxFWi"z[BˍI#Fw[&سA{ّ VM7t* bM`  j_5 `l؈XZ/F>1;q4WƍXcRIB`ꢑJ6kuܡW*c1֒9βU;`B_owG%c0|:LD0 k0L0&,=G9 (r*sGJ㛹gKhs_J~;.3&v$ɜF y b.tL(ؕ3F/O ^y,vlTKR[R;OcV-@!ԇxOw9DYn?2˗]@l4 nn`v)TKl D.)eC7ۯ2zvv=eh6\UCy`םR6/O޳`L25nTԥe>Զ[,ֽ+< "Qv$x9+,,55}:c.K[2v+wak@.G*X6:z+[K``w`$)*R)fUtTzKvMc`UˆA,죱q~Zby:U,(܍rt y=nmKdj8&E)qMcBa}> (=YQ 0LD0 k0L @]"#4 BrixUGA!Y × [tRS=63v붼8Are-sS 67ũ$Y UAV((7Tt uEOcajbr{ua=@\)e?Z2IGIj`R!EmwNDWt"۲{wfzR+_"}YuA)ҽJCK%|vT yޖ [ǂ-qCෂU7p xwjBȓHIzag)` :/|a|a,,w ւ1^ڔp9lv L%fq,kwX:B'+MGK#X`g}*uF"XoزgL\3x0TB&fB"hA0aT0 }#U'x4jS{u. ƖL I]kc,zOJ`t` `5& `&Xa"L)X|qO,&.pVKd.T#lL5𮛣 K @n;g /Ncuyb$^/匂@ @>eR10 A_M*t*m JM\`,y5vjh@n?]pZP~bc`AUJ0jzEP,y &d:H2_sΉn|Q^8P95m~1. ]>`4kF5l>Y'/h';Sӑ`}88tO/X qZMh5C:,KL | Pk5Gtͷ5zw,أ (OrRDkYMpﺶ:d.lrYu= hA5z)Xßfi{*|T2çk0L0LD0 aJGO #$ pr}YwG#`B+^FC&I[+L7.,Ÿ-wQx ?:~m\T `,A!ؔ$%(E 1aS)ݗԑEx,59dՀ=~n埃oƼ2#@wfGXR0`sK *B|SbQQ%XBMGx;\Luu= w:ՃJdi>!X/\+!EjB2%x1Ca2p^r pݡ*i VE9vbaweR`7g,i` fA+~`yI!V}<#X^_(Z-`iǍvW`U_ Goԭ *{`-B?6ExBy,tT HoX&moV`5+.ޜ#W YNj2;qH%H CdGI*Bb;/<;)%LiQz gGH-0` |0 k0L0LDQlPc }Aw(T;X.u8[Ԡ EKF3b&$s=2R:Ag5z|)8>uCk<9!=w^yI4%Rqف cJp&#:pPz9 t{ߛ4nqpd89f6M`,Pl]UT`Wi(Dq p[ɔ-cv`A)X`ٸ5FN#t WmU=9)q-y# L&7S 6TaGV7Qa!aUs YārZŨ͵;l 8{`7[Q+Er1,v[=TC5m2k}5`߰/a-^^Ê 6> am}5BBci]y*uN|ݧ6Sq]0V"dJ0rX9${WS @zp>dl4Q?Fke"|T2çk0L0LD0 aFz[RpPq[Bcܾ%3B>w׮O:=tm-[Zc}ߥ^t5`3ޏKpnB1lxݸ"H.T6C{ _t)I:6>$*'86@LQЭ0ANee5@|kCEtvЦ`XqےQCuG Zu3$a#``Z`]c&!zL)Xp$F_uuG\"5tpEc`:#)-6&JSB`Kc(I`(Jm|0N0$1D)5?}v=7+9[K +ɡ|$,j0Wc5@X'UD @!qnKư=g,a }XЭnaPa|E &ca!*Np #!WXf0ap¢/Vډ E2DdtQ˘+ʍP 4@d([**mSk2S\QCO,|ܳA+ $,6nJǡZ pA%@HDX!!a "aQ'PV "UGY,,Vh`^/4c+&>BGSx Yb** `@X' 06B*~v$/x Zb9JԿ5au2>?횉%fln2񄵛I@ؠa.joJ3R k9a !i‚CX ; ;d¢w Ws@|RtyaKj1v1Fd|B,5y,d1ѫф)6KŘ*<2fъZ`}te:7DtduҐ&a ;k8T!;BB  K $",$,b07H8X&o0J(fW~i+ ,NE>H:ۋN/ 72Ƚ`$,ȼuC ?؈A~HqGZ ]dT$ĩTNdc5.Yv Y1 R( ]ԑW9ptt6u$]Ao!_Kbf1Y2QQ1UKA*R`QWỹI `U =5fAԜа]RNuƧ+j1ط €gprZPU%[RK,aY$_Ps},D}rNtc)Z&+vrVXfg%dۺ[f5ϣ lB `rmzTwet~9`$HXs -(5,@ Z/A[.{%la-`a>fpAE}AdB1(2yUNd]:㧖DEy& 1~(|*2뜸f5}3t뽉/c2f9ӚZwRID%xSM3Z0{%7]LqComH+ ܫJLigcVX]-ˬ[*EK|LIlt~WwZr׻Noi}}9h|3Ӱ1ku+{[-[gjd ]8uh.KWX4?퇂J[GGc>o.~.q,OsP]F<#HSqF^x`'^[/uqaLK;K_LgPC&*$ΉמY_e7\O]cW?boIuC`-qomNUNCt7ĕ۽&$[~٪^ ^aE +</|\= ee1>~Z%4awڢjք;~%R7bNO,W!zoM{t}i Q ەZWd6qM%,S$)(O~^ /"nh&~{ OV(ledߟ2QLeUX& ֊y$-*loNl"Oa_hWT<)ɉ}7+;.'[hXؗVOzvÚ[v{}f-1c__-,aygtj[d^g <)%^_Z:=nwdKV޼y_K_^<3Rө۹TSa%g^㸮8|!C`K^R0ni(Hywf)ԲAjed/]ҽi!u\ہ> -t=STHKa`vjBE9HϹ?׮v'dJ=s3£U-Ǵ~%n7X@O݁t~*Q>xC&n6NP'b ߍ+iֹڧx#zsv^t7@k*~'JANZjs<#z214O|l[މTK<֔%^vaJO!t+lD6ҿ$kaݳ'c v}l$a#79b?dte Ӭ!v_}d)>X1`Y-!1,eFH ,up˗omb16H].ǒ_Zh#eėQpy1 jA$ ͠I4JM̅YAP ,$ |o5YJ {@y#l dPRut ]{0G3h/"ҕDw%>H?9D<"@DYOl%؋ZB2#H",$vP;O2waSg^U\a+Yr(f{\]5ß= lⵂKЊeM`REtuq؄DL쐊eZiz+E}Hu}n{k.^X(ʔK찊e[D1=[KXt4t¦5̒ !' {$MRv^{\2H Dgkmwg&ITJ]$~~,IP' ]g7(+O{G칔KڽDȳ5 G /,uL X_`e^HDjXC6oXXhȁ+2BDV$˙A62 qp10fJ9$x/틒e%0}Aťļ'6pDX0D2NW`{&f"9,1\q;:;*AWj%D#ꚋXL S}i ,( lg` 6SEӒ$S``Y,q dgS&6>3\aY[[a'qp ‚E&SaD۫%)MtpBs$ĥ޽΋V |Ú+J߰6Kt6f`2wMA%Rڣ:^#5@6 3XX3+DO\k9B|`GiL+oəG;K3N=7tS+Szuǟ8ڸ0~/ٛ3_^CrwCl}T7,z}ﷳ+pgJb};xeF4uSi?ՂSFxٚ"gpYnY SKM*2Tsf"ʷon3N(/a)PBHkk@AZ}bsJ!!'j8pǞ&h*`\%5>t4WrvF qf]a!‹hA UCBPӒ7BJVCq7N!:D6P;cI:ǥ)wv w OUҹW1aM&Lch0 Z*U8&vh[bUVpcn2;Y#`0Sd[9߰c$]akK8Owy1~J$#,=j8Tn8J]3.;U5HfB'|O>stream HWo[W~T}R(bhⅲ^o ס돨^Jji"ms#A! 7 ʶj`v3GB`w*p{mq5XQyz^!B"D!: LY"Dg=_QxM[,[kia9&`I&;v#_IC{H ~]#o5Ưʈ7*'e4cm a6fR_ X]'ul}GNym6y{>[?~O v~;{aA.KW_pV<8lrAv~ww>D+Cz&]Yrotɇ#G7[ .0Co 5+ aT$ؽ`;Ö% e%YaϽϋJ̪VT OyMP̋,/dּxCFeKwU,(X Zh'OS&-ޏN\s~Luf&T{kTX^LmeYj10*LS.dSn/"K~UՆg-Iz/(Ȗ5E5;}z=y$lUaG?8"wX6 Gw V}R/92>ec?T4$t,Nr㑃rSzAQ~}w%^& H&XwX_f1~F&K2`Ɯh5HzYQi:UH, aO1Vd4>c;˛H%cZS[- ڲI;m 6D!B"D!B"D!x8sbcLO;6+j{с\k|zrC,׃!`՝㟜qp V|7ʳYNb7;{'-Gs+AĽ||ǷZnk^#J}i5L^y#q0-ŻrkW~q"_"oz3]&L{g#?%?zBl*]{OI p wl- }n8^'ʜ4lGYMD4c~ T>Kv;Y?7`繎!VሐWLȏc_y%Z 6oC9ޥP.ȏc-I̞Ӭ<\ 6`T>Q/,oJdݼ'XZ*7e_DwYkj"&WU@ V޾RJOt@aQI*t QT!OTK'8xq -hmؒ?LiG-[eɨYgfc?f J*z{!.Ν  낥Bc xS&7F _!2+ 3p7i؝:?m?,f/X8e)'B-۱EN[KL S6~qifx`Q^824] ~e`i8KR%kyK%@$X2"@*oQdVJJd[ܒUد+ދ; ݏΰOwU5u H?zo_9n;ֿTi*XQCaiN:a| <3‡j k5js/)Pb3 mgΰj!ϰz*ŦN[T+ v*7/*}aN*9ʂU#9g#8VҍbZݔ`t`?7G*{Uʷ, 2ҡeVV;uwQoIӬc 7*:_5O}x#IP2 +O'_Do.eӟ8|hΰrLNίݐppYfo=4} ίΪ)\5RjkRW.}<uջGzw"XZނU\|!8YJR SѦ B:]b;J%*J:'C`uL7h\UT>x8U{zyUL(kk +H:svk#HEfNs#X=~9WdVe~[—NR vLdEps N14~hV'ϛoG*,v<;sp<`rTTTu/kEU@EEA(U +X(Cࠥyy-hKkϡYdLZb֒:/0P eԥ$`yXAuy#Hl@Xops>00G\ YKAiOy20XNzc" n2+`CܺV 2#a bs ;[[[]ֈ#$eAƂ.vB&XaTac׳?4>Wgmos)ooo3Xaƪ8d;uW]E#Ц ĭ74 wm /u es`u#7^z#ؐhx: H>-wgAy `/R|;x.ו?.$Xl a[dH"Pa9rn h/fkg—F<^Lұހ{@ׯ ,ѕéɽc(t-:MSEƢ TVT*؊P`b&x1ĪW㻮"5q b`+^m7ҿ< Y 2D6N|U.9[j_q ]Q$D^1 k&m"R{N_ "< \lmY\]XT`#K\` /4y[p.PK|ZE`i*x!yJA!nq_v `Eւ*:`:Cl=I 6<& -);X\<î6ٕSa+cLgؤf*en:'jX#,$,`׀`b3%%Lf㎢!vF2S҂ȲnDAueHGl+Ç >g#ͫ}9f.ug\(Jdi1 -'Q`+.#GS˰hl**6U TVT*؊P`q+So:vZzv !(lG0M(7FS mOc8J4Jx`r=0l1 |Gg=Vwа_9Dc{gnwT 6|TXH~ǃM=E!ظNƆؠ~] PDсF%lS:sn6;hzduv̺^"t|(zڲ йlY26qL=bTQ(U +Xtk0 *8`+ׂĿsjy g34pqDgWaJCla 幡<$W8J4JEyWZL  ܽk8.ct4Ah\Vc*88ǪU"Xh?B{v`u8l# 3Rz5i`7pK73F /X-~+Đ`U?fq&f fHfX89ƒM킝b;b(1>\SW_+zP`+.#GS˰hl**6U TVT*؊P`Q_!hy]yi)5#H۳\Gn|D{+GlϞcLQ{8J4|eaKW Пćb{WN8zN$PƓɄ2?/~ W\Q3aBx6jKOEMJyӉʰ^ޚLv"Dl7K2>=r2խ͍M" 4*YXpmloWN)>8"Eabq12K CR տCw7;U#{ۯ^շZkx^]uZ{nc2̊^ iY2c3*S7ײO 3Zذ SlX)6,DE a0Y  J B"J)F@Vo.ܭk`5c['Vш| DLC )4/M}Y ڹ(Tc'!\CңCOē" akh V 2)i`Eamxa:nݎiXvlXXʰ"U%f\ 2=Q-GdvE :s +0(߰ Quk76l⬼Vda0xw-+[#VZ(аcL67'+7v5;Ÿ k gmmv[u5O ֎Yurnkm\1 m6우 H]c(ih k߰d:3uakHax 8,*R$0(79#%d;[3"Y΁3 FRQ ʡSa4LL@;u0 0e`2LAa 5,I7R@*fu|vߝ ;S' lƒ왛z'CI*8<29?J 2f -垁Wp}a`5ssUI졇kX;68lX h KwUPls ac lmJnVXw oᮮ2 -H,dwi T$bX7Sj_ mf^Ԍ(6B{D Kx$.o ;bCv=m_-"x Q;úa>`T kXhg}0>%෤åĘn p4Gb z[aZ*yOF16 ?k-cVU~@ftvX#5h5wI|];`zޅ. fEtϕYkĘ#HDX8'fn51aF a 0e(ذP6.@a ) )锲%ho"[Q]8ufƦ$TW-͢=̈cV)ϴ'jjxLN4ʰ HfB[&c%4L k L*) A̓E0^]b Ԩ K!ӶeJ|&/|6 +Bêa]=73,,d3դO*96X԰QMa8:gbX =Y`&a#J@׮J@d(G:wz-ch35 H<8*wIK;kMdavX6zSٰ a!9< 6hĘI,G$P}-7, ' k- ̑+'}]oF7#xT?R`N);J&(2݄%~:ˀzQz3ƉEe2GNݶE3>1ha2LAa ذ SlX) f,AJ(i/9umEpV Y,Ŝ(1fE1j@KT6]MtDIBBU7 q@`X(H ^a#ÂHaa9&%.7vYuj:S(hpfvΗ b:qbd 3:~ul3,t́.'>K&8jKl+fhȖﮎ$kw[)KZ t.7JYaRİa(}P laư-cV8;CgX3,w3M(L*r,t|KXGkWަp9h[UmE3Ze5Vˀz(/cf+-Kf}bFE1`h cÌ6,a 0Qa!%21"()8Xm7"]PgZi7.TVgAHT7HCwȓ*sN;HTՊ R%ho[qL},l@u JS'MnN2,wp] 2úF_Z`mϰ<7)"V$C'[:Ѓ`Rõ>1ΰQNL%ǰS,H0l;dFeU=,l 9 7t01ha2LAa ذ SlX)6,a 0e`2LAa ذ SlX)6,a 0ao?>y ̧a*v0 Mo:e/x뱼oǻp;~_=xu3;£_Wnxʃckᥝbwz+s;~cZ4>b+_/@}|{L`l[^OWewX$н;l~EmUlOOpWbRUaOauCzsoqs| [Mn9paӅi{q}bo*Lדgd u<{Um^{aӗm]uEӻZjp+wa4cwÓܝܨhd^TCrYذ'*?fU ʽ;L=Lo1|\_?FvKAyi#'O %lh)ȁbiT Efa+)-KJ)AmKw844M.tmc1cAwzι?$kݙ{9ggιlmnlD_ߥZ'wwQZZv{TbZ`7!M{a[CȖaEFpwktw|m&UGjX-KUH g0 _w`?畱QېgaQ[Um7T*xfg-O"S.[$2"#30wW'Hi4;,GŔ[adؕX!~/3؎vP"`ĥZh2,M vJ[$ʰ.+ogf+Db+3]Pn,>\̻Q,``-~64wZq@<{&{Q^T{6VGj+u~ߎ `oGUܙ`>2--{|V}6*Ӟ?AVt֑wxC/_B39I%V*esq% ⲬڠrD!އrnGbn@s)qkSvDs/t'ѕⱚؕb4cNX4ci4' WhS96,xi4=>XU$9j,,o ׋?_FO7$47?=f`wz!]NsfW'KtAr:9HX'T 9` I8~f|NPB̊ͩH*򊱜K4>SNJBk"/``qfG.ǣfVw:MFE^0L3 3OpSF2/ZT, JG&G͌'ԳW, l̤@ X349\k™S, ,Ofzaӓv{ª _u`L, eٗҿ hnĬ؜$bNNɩ@r:9HX'T 9`PS ap#L> KL,=3fd%~y%55_Ƀe/3C;-9a`3ùn\OwXL,FT  r@dLF(҉mlun&%&yMW͈'cvbNTG_6sqMGLD)x\ω KL@IœLEȪT%q fnՀɖB!u2x=%7Nhs79lӹU  %ʇV#IgkYg6DS²TZcI6Mrp:ABAL .[Ax973T ('Οfۑ֌K: Z:K,X#Ͱqm,tT4VbJx`7y6S'V$9b+B8^{oD,7Y+:~_Eڟ*U0أKbӓVX !5[w/(PT u9+4)~UrTDe< WT%͒(13C:\`pn5xk [zeV EWXc"(N<=[`^s(K/pxkmU!كRfl½2[جE=Z`0oTA[q׀|DX+0|n-u\zQ6İNQ9j>-=w@ <:rعʰ N+]BRPtvZa܊:@XvZH$h [bgaD_^y9h>U CᨂS|ֶpۻ3}/ |A#w<*~Yj 2#tO^ׇ;7kϠlDa:\ x{>z}o[L~\7W^ K/Lb`~OfXh ۔š!?M6@^{)㔣"|DQi4p`3/Ty:t<F6޶;9ͽ{Dž;$&zw4"Lyp @1S#,b+Tf;@/yybl`Ǣ 6X>пX.tO_`|Q$.vI5,ؔ&^=!4 4 \K=3,:J`8SNQI>–~B֯@N櫋mnn4u(郻*A`t^_@%Š~r%D;1VkLtmpQz =S!$_U@Zhb)^\[ `6(!#c6|g'd+âDRB!anu Dh'*S\6">U;(!L  Fe $v*O0 6{o珣Pl|_w^ 6tnDb`2`W0+zG2+ qw !~ Ca?tJ`&-ζK;-=S77B M_e8YmcFcce{BLT{R[L(ci[Ŗa㤤6VmV^ϤD1SF;П։~|O^{:~#6 a_ endstream endobj 237 0 obj <>stream HWoYZotX1- Uqj&bZce0m *#- xBqjim }93Nv:d5G997M + + +O~xODa}zc4dh'ii<%K\Iv#8ɨ5qVUy waT['ٸ`/P/k=;Oa^ꮎbQ+ҊyUNAcmЭD [T~:TȂLW*dO4t?(vzF8g ez AIKH({*֥&AB~-$[BI;2njMzEzB^.{DYVXi.\%?f4_ݕaMSd Qs?RϼiWk4 't$4V4Lj1NU39 pT+ dOIG68:qY"GI8hjUv)Q`.$u  !b[|Ȟ$ieE62GOR^FaƗgl\i|q]O*Q6'%2<3}lI_n抡/&<&\4ӛL *_顦ͨ;Tʌ'~yC` >`iO*3 jYzR HItK#ؔ,UJ46QȰO-_ `#ţa`} ]X; VQĦ/r.Ui/ KS vSM.a(;+ғn4;=GL 権:Q{=e]lR=*,úT'&G| 8q,ý%1ATqeXhNg |bٔujߝaC(8KS6(`a}ckhVqMelBw$0Dh/?gBZMM^۠vN`јvZje]'"~HS802w>ԏaKa:<.3B)~HǪ {Ȼ>6GT{Qf4O2ʰ4XKI6 mCݽ>tIT:GBzE!<&;' Җѡ3KA/Q_0U8kAVzHeQC&h"ø,̒Բly,ȟX Ejm@EuXT \taẌ́N`S@g -㒸fR&ŗP_}$X'?]AdYS 6d U9 sNhELx\Åj8ˠuQ}c6FT UOD58}"g'k:Wtp9#3dSXaf=laVXaVXaVXaV!okiz+j͉^ u(K!IMWU|#1/CNvkۃ`g\mU'̴^iH\ZW<_wZOvðG e^2X(=8؜"&ae{7#`Y=Wr+cI4K˜**Vܻ5w_ry8 !ќ >&;2z2>V,sXK|'pV ,~*Y."p箑/^p.jHwA65ש5uDuQٲlBe ٞ, .xWoO#X,(C\YD2-4 c W/UyPu -`(,rSzSCg`}A/m0"}.۩/Yew6ܗ'O`;{ '{Yv)̾YvhC-2g(jô3*n)ɅW1KsW='˪_q>u[ўh6lRFv63yFzR% ,[4EB& (h(mL MGM5̰ 1Wh3]$6ThW}>Ѭt:%dCYWPς]ҟ8{QVhJ>vMK͍K5 fͲݗwfi:a7TYo։vx=)Ҹ:j_w܅&8|pH|Lht#T) x5Ϋϰ4hk36`Ytt\&<~{8ɿ !40b9 i v w<37E%gX)Q/(1ڇRo !BVfX~_҂=2lnk^am'kb7nr3`<R[G&^;([B[G7a-qw:'o1_CŅJ~|,GWIEJZCOjHpwXez2goiy]^R]Vmq:ھؿ;kʷƷMxJ^Qs-pӜa0XO2W[ǺS3yo &?uDG90`|\Q+++ XD)O4<_Eef8|^N~[pr xNps}xH>tTJ>< v,bƟi{v@08A4HeohDB` "!HF]2]qr Ǜ{Ė46ZkZY 1mY[~Ew-б$,՗(h* Rh3Y[cz⡜aBo(zܱ_) 2ΒrIb$a^&H VT(dR, 賉`Uͷ=jP"7i1hElEڲ=Rܣ0~.wtIlL/pWan`CbY@VYU ה q}`*%Je$NDjm26òK٫u3,q3, TnC8#v:Ke>+w{s VoIf,,au)6'XSY ~v-Yf.@G(m&`݆Κ"kp \'8]N)E?Al3lkc2|D-f:u>fn]wgJh]!57Ahʗp:)R 45AS,T&s K A%8 X*H/8 Wk7m˜7*[2;~,?ʜAcqPD$jQ0ޚHv0ܚܴ.g\{ϼkyO 洚r)ݕKtf حޙ(%뜪k+d [/E<*ٸv.΂Un]EȒ(ތs 6_CĹwu0a7A~J}yy^#MKqNDjg <#tG?w ]ʜQJ=am`!WZ/`ΕgX`hw]QlJ[t{Ʀ5qM1n^ˁ[2> +B[{3gy^F7'U"l$.mIl.|-(4lŢ:*51Rۢ /9"6_xwoAҷ@]Gz Оl c 27ΕьTƞfx|Hj`ftGyMP1 œq.!DB` "!H$XH,A$ K A% DB` "!H$XH,A$ K H7=!U?/ *7Ex45OO?#_{lԃ?qo8&7.%Zh~b2<6/'6(}Hٯ߸*uZ-ĄN$D$T&ERVKݔR؉qBDݦP%RRF*)qf޾]{=͏;wg̹V= + @ZRJ[ų1|tD๲^ `C08Ek :vt]{7n 6 Z=~h:Vse>W$sd鼾[AFvƃSt>k&H(8tlNU $.5RN[hM+T \"#‚U8%3+ aց#n{G)qYՇX^I}\ ߰o.b;UTe'E$E ,Ėv]ko` k5ݟWl9)b@6hI Bž,64LЁx a C f?_gh7ȗR;>}# qТ4HPvN'\O^xϿfbåbkEM J:[>'G. 91{jD_㙈'_ڦš#OsK s|>#MPL~!mm\hUiB1*ݻ%I=PDc,(ɋK~lp6&M| `k^/wpJy/i ;Esa_ \ɉGN _JL߻yl}ݯWgV0c,ݢ/4~;r5>+_2qVȳ|@Iz, $ݫ1qzncSW7*D KʽɁK؊.248<<Q_Q(0ϗva\;_6Zރl ,# \R!&R_)݃`=`LX#C`2 Fe02VZ[!y}J8&TBcaG$FXafOϺhlP2=10  cL6C>24\"o͙0lZI%0Ee X1a3aJ,a2**CXp6NuwPOUd8a{+X~?q V)1ؕOSR)2F;a{9#e*C~hoK+R1!yY #a02&,!0a `dLX#C`2u-xhmf6@yX{.I:#k[a)8VP+zC9V'lsEGZ^Β m12v0r<>;aIȁ'7RH,݊O!eD˸FtmRhﴑu˄} A!qOtEȴHup$r'a88;{Bh$@6r܉QLJd/%b0VZ&֜6ª6%16'oQ؏k,Z"Idu39$â9 ρ!o=kۥgO¶a;6 U1 ws nV9Tq8D 3q0i'$v1;O)Fk/gIzf?H^N\ئϰ50Fn.f F*yYM{D6 [{/b->A)ͻVyi:oXφ xfay&»V1] [y%\:FD暅a18y7uM':)-j>̄^SA ^b ԥb_9Dy4>kE JJ} Ha80ffR&2NFn 끑 5yv~ﷱ,uEG+Pu]~_mQK-z M !l=vJQkw,JNˍ%عL&:Q L tl;ii&71[V)=V8쾄gD-Wȼ&+ط>3u5YRJf }k{j (qu6Zl-L`>:]/Te6 F.3R xTX6NvxqE^Xs|0cZLܼ\oL Pl}%E59=ZTfI`(z@s ~O1_Ӄj@" wNSJY<5;a ()8(!=4aoV"A0k2n(oX<`8N|栏Z?{Sc3N<AԱ m0ce* G]Kc_C1T FoޮB!%|l 2N9&r5o=HbatAYߥ {s,g[+_EMwHM3_Ca' /q5V$yjңw֏P 2b7 zK\] QF`RDqbE$q>ZaW)M%’ž-uJ*rwS 5xPRdޥS%+صGXL/ع!%q̺Q{ SX#gƋwQ2m*|*l q)5_ӄ1:0a2 Yل,0p](;G%=W_3 ЀK߰mGa qL0IM5ԄeRMv3`)sa5ݶ5DY3ѣ;uPQsJH5lJ 'd6]8Ŗ(!C`4ېO~ P^9C%2N\5 :w`j%:fN` X93<ɱ,MQrP7 {8٢i9]k^v,W9Z.Wtkl,;Xm|C>[={~1^JK)ӗBOƖQ:ʚ V`ۻ?lи/x0  endstream endobj 234 0 obj [/Indexed/DeviceCMYK 193 258 0 R] endobj 257 0 obj <>stream endstream endobj 258 0 obj <>stream zryr/..%$$|{zyxwvutsrqnmlkjihgfba_^]\[ZYXWUTSRQPONMLKJIHGFEDCB@?<;9765430/-,+*)('$"!  endstream endobj 233 0 obj [/Indexed/DeviceCMYK 215 259 0 R] endobj 256 0 obj <>stream endstream endobj 259 0 obj <>stream zryr/..%$$~}|{zyxwvutsrqponmlkihgfeba_^\ZYXWVUTSRQPONMLKJIHGFECBA@?<;:9876543210/-,+*('$#!   endstream endobj 232 0 obj [/Indexed/DeviceCMYK 228 260 0 R] endobj 255 0 obj <>stream endstream endobj 260 0 obj <>stream qba~}|{zyxwvutsrqponmlkjihgfedcba_^][ZYXWVUTSRQPNMLKJIHGFEDCBA@?=<;:9876543210/-,+*('"!   endstream endobj 222 0 obj <>stream q /GS0 gs /Fm0 Do Q q 70.866 556.73 453.543 164.147 re W n q /GS0 gs 453.5432619 0 0 164.1476224 70.8661508 556.7302539 cm /Im0 Do Q Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 9 0 0 9 70.8661 545.9302 Tm (\022\t\217\210\b\002\220 3.)Tj 0 0 0 1 k /GS1 gs /T1_1 1 Tf ( \214\032\n\027\031\021\022 \026\023\022\005\205\003\025\021\026 \027)Tj /Span<>> BDC ( )Tj EMC (\202\032\205\033\033\026\004 \033\031\032\031\030 \021\026\006\026\023\n\ \003 \024\031\032\026\033\025\025.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 0 -1.2 TD [(F)-16(igure 3.)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf [( Lev)13(el of albumin before treatment in g)14.4(roups.)]TJ ET q /GS0 gs 453.5432985 0 0 100.5878282 70.8661217 424.0384692 cm /Im1 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 9 0 0 9 70.8661 413.2385 Tm (\022\t\217\210\b\002\220 4.)Tj 0 0 0 1 k /GS1 gs /T1_1 1 Tf ( \214\032\n\027\031\021\022 \026\023\022\005\205\003\025\021\026 \027)Tj /Span<>> BDC ( )Tj EMC (\202\032\205\033\033\026\004 \021\026)Tj /Span<>> BDC ( )Tj EMC (3 \t\205\024\013\025 \024\031\032\026\033\025\025)Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf T* [(F)-16(igure 4.)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf [( Lev)13(el of albumin on d)26.2(ay 3 of the treatment in g)14.2(roups)]TJ ET q /GS0 gs 453.5433139 0 0 153.3594943 70.8661167 238.5750847 cm /Im2 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 9 0 0 9 70.8661 227.7751 Tm (\022\t\217\210\b\002\220 5.)Tj 0 0 0 1 k /GS1 gs /T1_1 1 Tf ( \214\032\n\027\031\021\022 \207-\032\031\026\013\024\025\027\021\n\202\n\ \005\031\023\013\026 \027)Tj /Span<>> BDC ( )Tj EMC [(\202\032\205\033\033\026\004 \033\031\032\031\030 \021\026\006\026\023\n\ \003 \024)0.5(\031\032\026\033\025\025)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf T* [(F)-16(igure 5.)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf [( Lev)13(el of C-reactiv)13.1(e p)46(ro)13.1(tein before treatment in g)14.2(roups)]TJ ET q /GS0 gs 453.5433774 0 0 105.4751904 70.8661162 100.9959046 cm /Im3 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 9 0 0 9 70.8661 90.1959 Tm (\022\t\217\210\b\002\220 6.)Tj 0 0 0 1 k /GS1 gs /T1_1 1 Tf ( \214\032\n\027\031\021\022 \207-\032\031\026\013\024\025\027\021\n\202\n\ \005\031\023\013\026 \027)Tj /Span<>> BDC ( )Tj EMC (\202\032\205\033\033\026\004 \021\026)Tj /Span<>> BDC ( )Tj EMC (3 \t\205\024\013\025 \033\032\n\027\n\030\025\003\n\017 \024\031\032\026\ \033\025\025)Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf T* [(F)-16(igure 6)16.1(.)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf [( Lev)13(el of C-reactiv)13.1(e p)46(ro)13(tein on d)26.1(ay 3 of the treatment in g)14.2(roups)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\214)10(\211\036\033 \035\030\032\t\033)30(\b)42(\032)-21(\240\033\233)]TJ 57.136 0 Td (REVIEW)Tj -57.136 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 23, \023\0221)69(, 202)69(4)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 23, \023\0221)69(, 202)69(4)]TJ /T1_3 1 Tf 25 0 0 25 20.84 56.0378 Tm (176)Tj ET endstream endobj 227 0 obj <>stream HWoW f_{8i(->;WT*9 ~ ^.D =Yw"ݡT;;Ŏˎdy}f|fK.K.K.|a=:i 1dtViyp-gm:`NF4wiLQa誹D*DKNjDS01]Rdw`"-{@%S Oőm Xjw)9^t C'6:>8VlTFEm-$>C Ν#:qrQ%4I]uKS"-)nJ <;M gz. 6FD+8Zf-鞫X>co F(!;q)}[Dh+ī@68JrynMK2!MaSO%^cpN p8`U~g>X u1]ߑ BwXm!(=DS+#yxYkRQxȑ&,-ap +,AP@ j :TM+w0O R09@ؔiUbZaVLw|=|~) pdiv \C6ʝZ}W #2;օ{&T+=X51h:iu 4+&GԶ"Ω9{> x)s%`u\:^ {r}&/ϡ@/|g–ka?M\%l:,<.R,^}hB|]XR|yA[_>5ka`aόRy\uDq@7)v<ʗٹH^,~Yl# LX ;l7Ynl#O`CQZGt/_[l8K8%擽xE5Oc?md6kWj@p֔Sa})I{PP gzRaĄqi FvJ%PaK1o-VۓjC-}RٖP CP aԱa}&lqEVͅiTXU JZ`F6m团e(o +Op"%4\WJRa9R̨Fmtj!l]&@=αNK RKAV6^KAؒńN6BX4<W1A5\&VX@""s$|uPwI %Jb TKXw/a),TZ+5Ť.9a=)V4de!c**lPVa!$LX;A[\YGt*-^Z_Kn|-E2i+l'!z0}˅P!r+lu Ψ+]WbRÚUљű+|n1e[rO`@u,k Cgg먮:'lZS2#NJMө}ܢB@AQm|d k'X¦; t;nI*d36hv;,֐ k' G,Dsy\HkMƔL%XrK.K.K.K.2D*2 w}*Cwy`LH:NQa}Vυ5mZ=~c}/Ldd+gc!0Ѵ][67OQSZah/o']R*l [+GW0ӧ v9&w}dvo rBRKؖ[)<4QXѮ)&owxc$ޤmDZs)-wpЦ3¶棝g눰׌_ח=?+ncwIgn8!]Jf /ZO#{/U#lLȿ!/RDFa ءBbZ7DGbicTNPڈxЫ (:98{X;8 +`O%18Җ@dž6 깊гqmqƥQkA J( P2 i5]>t{\_?١ =,^VƐ39qUfoW&f</qTTa6uUӚG~ K~H0alKR*P}PWI( Ϯ1 IAX(KBR'mt&<@X%7Kx]94~Vdfа)uˌYG&{m IB˝j+M xi{\^N{nFaROKiMo{\W9Ghy}/a&/3MԧJ~y¢ؔR0#=ba)-6sfGX8?oSTN.$XWVVb5(b61F=8JY4uX ( 7/9*pXVySZ`V &v< ^ahZ{2BAKvCҸ{zk=&"VJktlK|c[߰*0"uj,͗oa{Y3n`"Lf7̖C-dMٸ%i#3<5eZ:.IP (Lf>HK@^h~zY)l_̔ "lbAHfc88W]2gwLcw9U]_Wk>#沵!?3!k\A<#\ V,k`Km H|{tij `̇?COUG6&8HbΜ"؟Ԇ_}^<"::b Um~Ol,5'baer uᥦFیEӾoMeO e1sZ5S>O?+Fu;{;2ȯφ_|~(XM;+\?Ew ~(|Χ掜&KLLe NހS~XLA0QWq󵣛?/YG1+8MrxTt]Pxm(1qK쳧<<ۭvQKRKj j(Eo w凷S;u3ϋHt,jtO>|~ە{I ?9f+}U ``w ƊHޑSՔɯKv[O M 9 ܁o)m{--+2"_|cw|S6yF k5[vN U.56d'GScvF򼠠 a"P[P` 2BUg3:2EZ{_gN-1Z3& &H>rKJ|. X,ef~N ZCk=6 ҨWoc@$Sp3.\,W Vnޓ[{=+Ⱥ V_mv5 < #;}xpNaijFKriQzO>e`i~p-jkOĖk'j7nĜ +$ 邍xuRhV`-~iA&mBn|5xQ4JJli] 5Z/{ # g `,U_8aJԩqz#G_g2KjT`5no&>M9) ^'VHwCѢ sU߂/V-ª3'}@ȝ%%%1Gbt&ҺE1ŭH}CIeB!7_VUj޲tt*XREKWK7eFlAAF(-(E!["qX&bi}!N&'ghP]coӉy2O'5X?]`wb;KErRc30gB-H/`]؁%5 P3lTfʫ0i!`AU3k`tM* N8Ю KM@;j_Ϡm2uPU 2EPeH SKb,5Ã419S3?f܌ ;B*66 bJ_S2 L Qj X`!W?g~#` {e$Z`KJKlKZ0cu2"~ B@wY!; U2r$`gslǾ{aA=z*D&X(Tha%XSEd)dU8@gΆffEg9#a*' dÉ.x+3>iUN(\nTI\?͠fNhWVc.mh}7(B-[ʴM`Q[P` 2BlAAF(-( *(?FS!. qOMDj)1. YU#G^R) 33 P H1%Pc]*QkVT&`ɐmʻ#Z9bus T=@7U1IͣE/ԔF V-Y10 6)&ă7V\^ R%΃jNka-E" `S&Rk@DFi:,VKB3ANWƂ$W{6ȎX>Գ`;36^Nqj%z 'Z}1*]c[96Ȱ[]vT^UPv?u\d.~;-9 6[[=ONv wX`FRGGvPo2vXP,+&(kDh(L'ZsN2@%uGi@.F5 L\` fJmM`IKWK7eFlAAF(-(E!S*ڨ*3d(?Aߩ!Alj@%3J#5.͢M[O#8[/c2kg^`!*;b3 DM900FK@kY9ɯu ­]+XC}Ӭ؅Lw}b]],^"x_@ c*14 XB;phuP}OSj834MfY&@)FтumZlˁyUu,2EwZY@}ްJLB_d)B,QvHk]#X5톆'='SdGXÒJ=usQŽR H  e~*: vVja;#1[pX%%S; z%HVrUiVŬCEp; bBhj$0DjF#>fw۰>#`4fU6MÚ NEA[6n{&Thkť拏PA2 #d"؂`kiXlZxtrl8Љ(0dT0cV-@8#e.zc2kа=_PA3 .jv;Lp5jꛡ5ɷnR@VSFQȌ?U:C;cjni[+-`Um0NSݎK t-20TqXԦAxBML%X6 P9cUA߼zl~|-R,ry`,O,gQepR V#.ט"vpb;nKS)ءsU gab6FtX`# ALG8;,00a+eX?Bq u݉PuXL;l4 EX)R|Lj&6/W1v,A: PokGbN?O939}'4X<tc8c'Kovă8mlXN}tE=tPu:oBOW ]}nB;eڭ㜸݄;pL1\DSKHΡpD{hDxE8B-PƱ³يAC,*'I~Fv_v=mJ1b Ȑ?P0c鲣DCH]4)d5& &I"SM@E¹ i92Q[Z4 TqI2 6 L`#4`M~=족^ 6&Շ]xCr3aS*11ɈPňe}fKH ~)}BF"J20H-.GW!4-)g:TDv Q  r`Sdt 4?vBz>GX86M(8>Ԣg[Lqץj"{ݺ򡌈Zl\~?ǟ^w@6(ә#Hőٛ:>َߠ^B E;PIWY9_AH|>DA \v QևH,IqPP{MMAt .!i˭`ZN'XÂUۖ`vp^kX%{RC w0hPaP_(X V@# 45mt 9`)pl,ijp^7,fͺa*(N:KˈH zޠHFC {%D*wН(Mjvr8 1\Dp:aR ~B2+xVWO&AfMMjyȰ>>x/=L֨ $R7!|ՂL F 6f)H׃C4U!=;N@/Y[!.Cn6Uz,GJצ`&X`J`PVWvH/#Xeo"!5F@Lt/X1lSKᗂ;la1vsl4UauUl$r.F֣F h'hXm3y[LFO+<e|~⭡јpneE@!.V5n. )XYlcrCEsPḮ;-vslxv0LL^b6rZ65֝J- n%r*-X9]:F6~߮o7! 2VpqNnBǝu8& .Xc"L+Xz>4x4gKP+o"5] &Kf="; UF츧hˇ`6  cF'~f+&nGItǀl* y"LF@A6Dy}d J/ 0Hĵ,M " Uʑ-K+[JA >_O^ǧl(@G -X``k"t(,$;>W 9__` vExg' 6FU1(XQjBafG? Vdžl^ OԼbs(H|hU_-3ق f #* S0:l9xShꂥ_8(^ X.K, ]t, yY`sQ!2 臖`W FT 6z`o}jeM|.`ͪ)%떮u5cewf<PT%J#E:^ XVrYU",8s5@@qZ|-)`Ѫ&X E'a2^k +F"VlvgJNe\B .Ol^ a_`xz`٢=8 ZuX=Cow{R lNG˥6VFÐ`Qo+-qSX,< +K4&ζB`[_R@b7V@>cˆ㉱kf9/uа4 #E&us+>,+0`S 9ΉM3\Dp:pL1f,@Kj1xqfS igK5^-;/E-Skv)j{`v} Cav`#  t^ o HăhJ6fങ5 \1C"i͓sJyzI j@eaB:g gfؐc۩"J}C2OBc;tԑ龻lSH$7k1ԥjm5F:V&X΂jp~K I*X[Ƅ[i.R'V;*DO,v 6'lt,FJ&ęgJ*ipU2ojRY/αE*X|M lCl`F]:R3:p_UXGgKC*m ^;lw Q{CkmfsXYJ>&,T6zq7ftG8 ,Z?@f5`@XX8:IlrD#GM=$n@f@7_a}/-,#Lq=.˯!*V%@Y? ϧ;Btauw䪂ٍW+`JsGu E—x|`^ď K3s R}BUe U6 m, r6&xՊ}&[Um]-P5Je)ؙ{莰\BS&Pa)m1&|T\S0$DB- V)~"gu`(l(p5"b {pE b%yi?uhx`}߹aj C_J>=FC?^5`B'7+hh(Y & #sMuypC}Ve:40pg  t!؁0;0,KEd٧ЋWUj0biaT`fF+-m%ptWb%>ďedԦCcjabf!Tg̐o1|@Jxw44)ntKg i&F&\&d횽o,e2 tvAЊϟfOcׂ 'P맚#]қn*E,C*XZe,@Lkz n`sl8gH*,^/A&@8.i(eBX `Ciqֺ#șBMQ{b]aM%낽7l\`yAH)A͙ BAzQ8Ax$} 9OD6 ֒cl *+J ٿ0#Lhꇶ.IZb0 =ંUj %sT fA{߼Exu oЉS9(9/cD}K 킍UҰ ֠|GN["1eT{f9miYWEiwTu ),$W,FF0.#N{)V{;ZVOdPڰ|-IHb3|l#ԙ#7 i4urhG[+,0;>3$|Jj+ǩm1C1G&0oE|rk:c A|+}ho Ues*`eU1m, W7ZtAyX'lЮ 2Qt5EN$ظ',_.$ذ%~*N 'RQ ȭ},.S߁NE}AEԌnQVpGnan+eQz(NBY<׫>@TD%_ a=fPKx#eyey % YT*ׁYnվb,5vϟ} uM6>'wDfq2 614 M Ҏة!"6Mea+v#}v!XwvGPa-&{f ־y7D >v'Aא(XӂͿa]*R).zpn썔m\G5ҘIP.u `xUӔ*}3Fa*:`}[RW+&`N jʖnAKQt^Q9 d>-}Ki"XhCf'Hy[˚F4lPEYsFd݁_Z?Fr& +RrXv;BN%Nnף R_:z' lI-RҔ<3,;/jfgfw3ϳw{ MGQ{ kXbeH ,!1,VXbeH ,!1,VXbeH ,!1,VXbRpX{" bjI`BUyOWt]u.X3cq nb/WpkC'jGw{FK-q+jjDǞY7_B ?wW?F,T-pI~N~6GZ~E{_Gj=5nj#9ty׺%mI`-m=*κ.)`Kw;ˡ9}Ÿ;U'w>ܿZ {J9 RnP{,>2t-B Z--J̈́G[8Mbv..-#*To ,k ĕ/(%VE i8w&8OtAr\IgX\\џ|iH`WJśz q)ǶSg\ ow­}in=*[Kͬ.΅ofE YؠGJ~ﳥ6 , v<?Q3ʙ;fNu`1OD`aK*(•] yZaȗ*X~GR)yJ^l'o2[+%1%E'q)};s5~D'$7K7XZa6&Zϯ"YVΛe,%ݍ- ;G߰_O8͢Rf8_Z|.ߠENll:%\-|ށ|pQUcu.cl* qƁm;pS<8.vncp׫zN`̲@nva.f419E,bO2d `TbMX+Cb`Y e2$JG/u,e,x,x!9C&273˳ s)ȫb{U|,+aK@< 邗C qRD-NW5A,{oq2hߚR|3[DV QC|D$%z16vuL#W6 +V(*)rͦ>D8MvO`@3-lv X-#l?gQgO?yVBʂazRW' RFU 1 `faz后ЋSUu᥀xIIF^YW`Ȃm"l5` kjU7L !Vk;8]k8iЏAv\e,xXlz+%v o N NsX{]FX!őU}rQ$+-ơE6Xcg3e*dp7l;j?k\y=:ǔfc{59.c;kQ{dR6-?q]Q/1]=DL 6'}`SU,K lqd3}Q6J",ʦ}PB7Z$h)p|ɅH3\Dڼ8?/}ͲEkר*gXt`'aO"gWtX:3+V9sи> ^ό$ qC?ʚ6CV E#z5a&7eq+zecM㄃.VB {hNBv7GO[ej*aó'!OPwOU;WB!B!B!BW.& endstream endobj 228 0 obj <>stream HW݋Y FT|tV/V `b`++KEÆ$= R vB_3=34ޥLO}:;9W + + +l AV"Ki%!F7s0_'tѱ:Ű@3Bv*,չ.3q( qI-F6=LtL1lC69gf6U<؝ekر[goV?"f\VvSK{h~)*lT/ pCf=U0D @\*2@QG {㦴 h|(ppl |m7"2x-x!1hpR/Z_o -v:ARX9& #܁Xm$^ITPi-q"K%$_ ,[^#vP,lm*T}M;6P4+c挃 E_0cb qe.,6-x+$_Gwd%A"vV_7ܾ /@{8nK:0o&%4ه4|E zWk[F~~u &jF 9lR bx؞r|% Fأ؊+ ]l.m* n5!cCw V)2GV$ZS]%h*,6WGCNCH9)Fi-Q"_bZ ا٭sHvLF`)($eMzbcyqSt9s_ = ̸q#9KO(%w\PGz35p9 FE5v.a&l޶_dyC<h^pͬҗ󔬎=xg"8'` /h.9z8-?xAE+Uv>䉭Fyp$$`È/o$qh+A \Ѱ&wGWX nʎf\yq-ݚ0`ivڒ_rh '#7~[55J,OsjS+\U¦c*`/ Ē_ܬSdjtxl*,a /0aAoOP\0gFmԃ]Q4P3]s^aQ`5xTaM6E-a]qyZ=xjpL6UءWXcTئ,c59}N 6H? ;\IDKgخhl7,[!xl8wYSIf诛-an:w,`& >4$Gָ !j~3pX=hZSPŽQ3aJ*,Q‚@LK c"}S ) ;4cė<ʊeBBD 2o8~Kt0秋osŞv\a]ji),_D%m؅*+ٶjxxaYKKfGM-q-ʄ cQ v__TOTX5vs݀Q+Q{{~X.aΰv:mgX$y _, vCGM`Eh^WXË84Ü"=+`~'m1:'7'4s$UXa eݟ?'nߜ̑TaVXaVXaVXaVX`-Zot㦳Fw-!ѧWACv,!Dwظ"ZOv<8dj@Bl YKU;vkmRϦw*n_wC o?Dm dY՞xp3S=ت-(=-m/jMUFo'9:RA?\@8sTcGqR s4ؔq-[#m{܉~8k]Y*sZ- YˮdA{|bF l^^b{,l@Uk{;րWrfra+kyaH 060^Lw_\Ԕo2lK! H%a Mg@̲2JQ;\KkZ0祒)h o+*lksCh`-Y_&QL%OGŏaF,5U}8\Ln7`"$A[ 1 X,,.=[jvSKM5ec{5hhF8lR8uGzCp3qc!]c1ħ@:* ncZlt0Df Ä |#/X,[w8}[", >U]!' ,͐joq-$`o&Cg8kבW>x nB&+mzWn]$P'L̹B \`Eر|C7OxX0X uMBIJhhӣӀ6mxWi4 UנWnWh;8Lbc,Sω{CLt=ADz G p2ė5 qnn*as)q\`VdyTYJkxڱ ,+ȪVMjg/H^wDLlLDxXbl,VInUx`!~uT6X.]0$[@ ٖ鐂JՎD\))hE7ȑm@e E93wsf{;_ǜ9ߙ{9gU%T  Gw~./ t\: ᗇWC9҂_aE ڟ2שlOEhW8MEb(-deSw>ş(P<=n2/fRvr_xGZw*gb_Qj&߅ww(M?~:Bd~,Nrj?GSkU EQIa;YfVan᷻|e7N'[RυѹmȔo{cV@eK*YDZ[-HW`r3%D|mC^@ ?8oc 9:`pl@14p1?ŞQCzE^eDۯ+0hhhSo )"464T&؆P,3/qx0-(YpO0 v+=tIy-9sc`N0ȕE> 6h01 CSdD8!_WgeA"|J2Y{!dmg׋>3-:E UX^"XOEy)I@GΓl^1k _[.l Ek~6 orv4oA1e-q`}k堋aĈxk,3F]5ӲAHP;mo74.ų6 ?* mw [{cԝA(Xa-9RVXyÚ*lCCWg}B7Mݍ@N`9ok0dKd26v>nnQ2Ń7gX`zeE(&غcdYkny)PtyW<)3b礪'k:/%$]#`{5nҶnhhmhM  "464T BM3d v81 Xi'#óP cXDH-1{ꯤ#ODnfw+M"`"zCV,$v|lE)՛6Eָ* L(`,TZ/Y ߑ/;*XLhP1жud5ag\~}]]0M1 %-1%& Jl F2,Xgބ-f܋2klӁ}V_+y Ђ.%m"q+X|w8ΚPa %i (I- yEMq3l 8!.Au=`5@֘Wut0, NBg~f=.#T'){1kBz˽z,&gkSl' Iȋ R5$3?ۚnmXz0(W^/'W;0;΁,[r) e,*nmvXb 7نVłE#LfzXn`Yzz 6Z#;B)46 o ڭe No6y)l."'8J:-`:(Xt|nICP% : R"/%[Hu*!þη}aŶ.›, LQ`2n=`59t.]ADn3$5@ 2oWaS'L(XY``Cn Μ q?/a"+ z?]`S^!uk/`8})k=Tؠ mN`lTؔr+ؠwlׅc0EL.WòK:h| ڔd YֆUȒfCr|ɩxv{p*74GnhhmhM  "464T gFd.JJ(rca+^AgޚyOt=9Qa9 V$͵Ac3qG(2lLq7WzT 1y=l ryIf8&ԠLl`r]mOA1B)v^;EԬ`kKܛVkז1 O+iM1,ekX\ ;!X])-1J Ko|?RC` BVBȗX*D 6D4}BP UCZ<Rx&)X]AdY؝;{qO5s7l!HJЄeBmª*=mevd#>6HNa aK:ܽªul bVX>OS!o)aLTg('Dر5-tV#.R **Q3W]+4hDƐJ#OX;ru#aOa6͵Iu',mZa"5+!,-m8a)VɀBL8"a!9RXx-DĤj^F\$K 0MA.z(YC]ē $,G@" @x K҇IOMkJAɔ'3㺞H-%_EOz tys|!QRxz[}$ z.⒋"P4Dǵ=w-%_EU,5JņԎ1.i p#fg۰=aDkf_ô-]{)REXՄ5 a9QOqfv̨6 Fm\suwh\ضάð%曀lXa-iδawrftM֞qҕ5m:93&CU [|ֵ x)! 릥4VXґPa={AEu7+}ZZs*$d A%(a=ץM6kJFB/OX(mU*~gX XAv**MZƄMkM;KmvxKF,=wkBĕۙ`(i0r;a]mqq^M;1.n!-DBiGYj2B2/֪;:2w#6jߕS F d aE <HX#xLXPavr, 渾2N^k:S!uAHB%Be-+=ҎYƘƌٙM3aZIVo2Ȍjn^I}aBH!%KJ%?Ev1sffo6i ,J>P-/ƶ)_Sד!nUU6LyT( A at9SGa}]2%,PJv2Іm'k5',ms&C#ݸWl۩'yOKڝkc`;L~sONMZ"&͖}ĦOv7gp2p4ZU,nPaAE[)){4Jڠ6agg-12yr'A~L acolˬYJWFؼLmv . X#eh aO%l'J!K815l+&f$ƛB&!4H؉-X{B5L_Z;*RYkczw.$*kLe"OD홂2@؀= 1ͦz.|sk,қt#9vE Q7Fi28ax~߾6$W\G }L{OG?,քG%/VBX|zy-FO^k(UHoݕ?1A?\݇`a^ƿ!gAeB^]2_ABʱ!\N6t7Lw6n|'^UrNXVECc7-Ւ$N a-xXANBBEx+ !^=v2,L Nإ|VIؽ9ݹW{e96/*s:ןJ׮-b[̴+Β&KnF|[B?nW@IY!`''ۓ(VޔTbB;,k"4a77Le%"W̖x/ŋ2vWq]١vmVN[,G:(1q ߹9<]b'SzUs[u,ҭ{1VX|rg#o/%lbKȪoش&/OtҖ+,O`KEG+:&uۏ:7;aooةF2bUEzZg$aY$\$79B ,Kϫ>%?>r{>$U7*cB|3*ӏQ&̮f0-1¶l29R1 aeKo(Zba! KyXV " g $l&u57&xO,BXJ /7(?^">T(}f&RȚb"nm[0;_tIh>cJ p"Ϲ?f&l;m;ss=;9gFaL+NM L"n-L`cړf7USx`8 -b/x"`O8dر-qֲ6FV?]alo -1KCqs\EK D3e5͵HhKǥ˰-5`kSٚqv>6'r|$)/K%c{pq+9n 1F,>NAq'6cʈy[,3f<=`! _,iʹP)I4CJ){`u* + D#`I%>V2 \f\mo/l\WFv"bY2&WiJ GwGRNaWTN7²/OރI;&?r˞4Y H9Q>O:>X .m03.܄aedƳÀ)K~)Vӌia bg&/!4jYfvh-X6ux da2qH{4|)qN|kV ce]<2u2ev0aHV/Q%MTw{PN;hg" 0.TKfxfFε|'"pC3o/$)j)1rm3PK<!kYHk'̖xԜkNhnR)G8%Y>՜''=N^ʄ62!աixt-KonIo^ӕd[%u9_sOs͵AFݷ'`˝W"a%9 >YkV?;ŏ^ &wU;EAP1ؿM۝ Gˈs[;0-qc~$ܽz v<*EOַLx},ХmE&N|wةj?ܰ^+qAS 4rX-P>I'zC++*7!m 2 L䭀c9k:^!º`q%-tK+c+ |oI`B]^% ko_ȻؼX)ۻ Xw)N,,R|OՐQJN]W wc_Yd/h[ ͝}jS:W0=y;gʾDFԎk%YaڊU3 x/5Eةi*a]TBKyv(2Vv*o>6<+"yn*l9}E ?mv YHZTX)xݴ%@=mKF>q.nx`tBݪ|*U8K>"O6N sB=oׅi_p|;uQ!=xXa}(WE"8ӄ&X䈻ؓ( ~UĤ9nCYS`+Pa+Ң6ꬾ'QА-uOÀ@ ^yXPq*Z]D=kT++,D[?Je/z7%Oݕo%ne. $҂J~K_MD5jXD"H$D"H$D"H$DZX'c, endstream endobj 229 0 obj <>stream HWaoIuK|jO8=*+.-5`Qzk`땔^%:>Aj?$BrH{w^MƷ9uucc$fJl/xJ()BEd}/+Q?ꎬ"F(=`Vt ֞@=*5`#'Zj+:BRWR]%{.l,^WxUSZ;j61<3K%r0?#oX<՘x&sI./:(fc%$w3ǥ'fbE\bq2,TYŖ %6gٽvQB(`8qRÇ5 ۢ*iTx;))|s#b!a}!j,Rqة_¿♺u$-fG 2e•T,I=W]dPb-zIшUG{!*)|5 KYӔao KC=ԧ*TBR6ɰzj&j]a}~vx"X,Tbt擯&="D_]gW "D!B"D!B"D KCWZ_=fffߟJK?f[2o$(~@)v]z=ݚyNuݐ^n}b!oޒAe=8_DxӞ[;q?_.]PٲvO/}jcv$/m 4~a&lgDz0 %Y>YZQpdFg?8`f=6lgL`=nM{^vO$>|~& -svg2hB1+4vjؽB>>]6;UZu>Xhј?7 >߈B;aɒ2x;}ASܭiYx gqSn,e#䫔a.dÙ@؄8rgam +eK6~^.SW+\rܭ56/چ-*yJjXhm .YdF*]8 D%&DM.&E#w5FvO}+H[-̎*Qf;A}*B(u8&?Aeumâ̔֏?+ sS ƲJepNFTlM쟼NRIؒ>C\-=.!VFZ ۈ(Ң6!ai}#a놕 ,IпDMP Jl3ŗ2@>\цM֘6V4Rj >̮`v #v\T4;!vfE6NNZ҆EYUӢWRVhN!%q!Bp B&q'逫 6h,fLJ!M3/WN@oc}ܪ:UnysSUSEYjQ\_V~d\믿rKɍ ⳃ_|Brn㎽c/`.ݱkXzW*쑮${XZ +gz]˹WPa$l5`M즓pJ V&M \9n-;+X;=JGmvGw|\` l`/n6!ՉG X~;vѱ/-7cGL3ӗ:u6 '/MS) e{_&[{p˖#ZoZh~k"tA|:63h6g#ם ؝;v/ˎ*X#XgjUR41s}Ɯ! ΰ(tܤku\m Ws{wf ~_Btqzc?v퀝ك_<}w;vvkuYQT7!~G%}}L݆× Vv"v| A<ǯؽyurCykO KKGW5яo"tO׉LǾ b$+ON (\uN @į11niE>T2~ x\:+h yn`{^aFf vˠDm0ڥHz<`Mk%Tؖ7y3hv]nWNCJa%[QeKkIQF77o~ok-g,q:h0D%`u#B'*t1`T,QX FE`2f I X:dVе'ƈiBl]A#zb_@ ;mƦQ-VKm(,)qmxW *,07pg[!S+ObM'g{7G*4g)d!fb3]1`n6ߘ/5M;RWeqI(X@> u΂~2-C ᥻zfp| x@*X`E|Q`i$/#T@VcPXG*Zk$l㸼&mu׺,!6E|@y`煟G@`)Fj1 ~/^SXwbw 9>ז` 8v!H`A{NcAťjMi)2~cq3~.29;ێ`3Ԁ`B'mB},X"`e0*B`w fR @4t#8#Bb5\ĂBK1 =Y5Dxgk|xiX;[Ycb(J/2{F sohFKi58N^ⶅ("A{eb謰+O&$HMoI~2JvBgp~{|ѫH #mdҸBd'~Dā!egHyٙXmŅ`f: [k{^ǘX.ݕ? 7yS >C2sC%Wt*FZƅ̀Sv״Ĩ׺dH5\ ݍwdAdN@z΅U`CLa&tND`']S;,LGN5lr~;B]Dv)v`.C۴ԙyw,p_#ԛb9ml*3v0Ţ=-F\llr.InvHFf,.OVXǂM3*lN0cC\899ntL3!.;&kVL-Pgi`OpH\#X ["5i-;\`^fضgTy }]G\lSe4NꤖTIՙA}ʰ4JD[B0C~קZXq  B6X!@`!,-X>^; 4 u3p8(U|N U<]5vm?v:ZMTxޠ**1@"WawH&MaFPv9+^ڡu"Q\7Jzcc'ISS8&XguXRNrv(utWy,?Lxp6Pa 8^T y`K D)0\rD<$6! Vhڂ~`qfs}쨜'mBn)pRK,F~i@즾aU5,S9yNWS+UЂ}wt#6>Ͳ`] p.Z>vN*HUMN;꟎&!3]qհ+Qɭ"-Nr|Mj]CTIH{.gcWHQ :2Z;ٙkƃ 5 BDJa-,-O } NĠ[fz@#,l BBXX _ǜ1!Ît]R+vvv<>*d*l/=X1U /sNN.`t O @z8 shhzɄ#=M~{tL6˟OS`7; S8ߤA-Xc ׂMv*/.X<~0OU6U_M,Gc=*X0qN!< "Ny6hΡWlލx{R@@y w.Y> ;)X @鋴-FsJͩy)V-f`w BW ;ciFD0 t0.4k湫L0߰ 2`="ߺ¾ DV؇[,>%or Vu@!=[be->=JU'Ǹ<,,V؁`Qy$`n 6{"7_k`4(&7ݧͱ)n:>4Ƒ15+K/9uoL٤M_kaa~6^b-8 !,l BBXXt{3yKbgoHokǟs;)% 2kgDGT+zf.l$DqI@'p.`S;6` d@{Min63̂1ͧ鶝?aO^kJl; 0[θU?YˏFJh ~x_6_ٜM_'9D 썉:b/Z1B%NMvլhHv#bZN =#K$@)|]G{pZt & vZ-r7!S޽`Oog;ys庇Aau_t *`MNTB'B$ H7 7' VZ jK9CîuSDNAJB;HTy N#u&!@$8z@#,l BBXYyR$n0ǟ\^~9z`"M+M'[Ɗ]h:E/o$B= em" s4iU̱i|dM`|QZNj՛l>&^A%9"nPZzh.?PY )X'Xlӑ# ^\ b1%,kդ+gZbZ5PkGoDP6l *c.(2ٷy}vb*A~9v5,;JYX``M:)'ԂM#HUaπV5!3A*B;up~Pȵs%~տ[⤶?񍊾l'{"D:`'zۖ6iQf[#`u=jf?$6`{{W';!6/عC`D!\uӐ-V?CJl p>`av{ 3 B6X!@`!` ʂ7x|zt,j6R3x+Pb5})vŒy,$ +j17jK3FU#REaMdvfEpv D ܤc "0q 8;bF*֟c}ܾݷ9?֩:Wʤxh[,;qt+9)CL 9``ހ&^ }MO+XJWpʤNYUq1BaR$Xm`%9o`Uw0 uoHP%ƾ`7T_CIc;V SAV`SxC$Pjq(¡6l֪J BU$X^]fBɍ$XYB ^gr/XSe`퀠UoXU%HHHlRm5t mi2t;S>8t`;lfC X#qȒf<g|M^WlVd`=u(iBS Gd--MG 6{̅׿w+q#zl0`@z ҷ0KC C0DI1 S#I1qE  H(X"!+.rr$.qA 1LPid#e=u;tȮқ~T~zޭӐ7L,L~O(w10#i3vCe}6!.W zȟ ` !8(,FlyYmv(؊DKdq;k^ ؞P2U# zKw4p X VRaiI ,2%>bϻnoT`V*`qh$knvAwQˎ `I\:bv ,dw'MKlt :&qav` ]Qb@" @$,,0 3F (#PtrD#0q/#] cX;HvMZ3 ZIܑa^1EdŸr.糳)d ۈfvz~>)-!jw e &Tt:`(޹؎Z  dODĞ`Ebx䪼`r#"L䪮0N>Gս#msZhPb6+~;=ȵyv4:9FQ!ؑ9k.~;UcPǁu\o-qZ^.5 :epav`b؉!jc@a`E  H(X"!+.a?P#tWD,2ABȚ %NEo̸!v\vX§5#Ȯc>Z xdNG%&GIL"wA78>v!r7Oo6$ZfCW:4Z̻- $Kf&[}Ydo W=% lY+f&GG-dש^KGšZS`fnQaLmJ#C#@欍ĎC ؄`dW,x%( ZMV;`u[ ̶Z;E& =6R1Gbg"X16ׯ_SAաje V{T㨢LMXNFr?YJθ6$,Q/0`6O ]0K% q40PIz# ,PDB@" @$,PDB@" @$,PDB@" @$,PDB()؋K@`o`DD1J .0}T"q'U;\ޠ+]٣w~uV*=vmޤtklVMH SQt29q7Xkkho?bO[ Xc] X;Pcg~gM3^޻ۜs;(#\;X(mrl/hZeIvݻ&:?xykRAo.fv_IՔ2ϤC&ڦ%wf,# '8>lA}UN\,”}g7U ͷV cڷW;!~M67,E``|NNeYNtuğAu`R5ߙH' !3Bw/hO_$/h9;#d m^YoyM)+n~? >-4~' ťKg(/ )hNO D6?n5|-3m:We`W >ɪ$ YE2ޒC65fBUCV7]`%E-Βj]TT{ZqD}qX˵0nk8/UѨ-Xv_;WL&B"w۫ mYWŽؑX Ōe{ N;Ϯwn__Sa^ G28m4œ*4e75/ح,Oj;#?8/ۼ®Ʒt:G7O{Zqݓh>x;ގ{r~USOw!)i ˙s {:=}SIJwXZtdПtLE1/8#eoBb"$Ġ86+Gdr!^aG@B{qfJd1h&,$9ziFJ-~WգuO[8+(^7 /><|OtQ ,fXVF?_ni\ZT }j~>L}z&zydޔ(^{ ܥ_Nƻ@#72Pӱj}20a+7fB61%EWwѡS8a`71$ 'R6VJ*+*,ǽγ HP+4oAVV bMSbC ,U"1,VX l$LQIWIH(IYBIBj:o^ nυT]B@ځt=ZXa&ʳyS%!$a lj!7n?_z!.f:JBBI<XW@_٦.1! GrϿl U!r' ' Pq&d`O-`_^ElS;Qo.u8{3W.y^9󀵓ɰq3L˼Na-I`eRX/Ӓ .LHi`=KI->aX* % ؒX~3XMx`A&2ˑa?DK쟎VIH(IF6c{?@Jmj TI'/Ry `c >1 * % x`Q4 i 7 h;)2۳ s=0;z<93Մ h-U3M5Ok~n3/-5scaӣȓXG /Ne^|[(SOmƫQslPT>r@  daƾ SXbT )LEYi3Q6]dX``Y%%1 +2bTXJ)4}gqӸ0+uA֚tcgpBN2-a$)Q("mgyG+l4̄׿TCƩKG;*Զ(}mv[^w4ʹ,FkGw/Ll/vj"b]@% g/AaD4Zlғ23b]2ي}N4۲7Dl&#oX7)(Ba`Y kʂdXhgXPdv˚ÐH2e`˩N. fB,O?llT$>h-z'Q<2:bWl,X`?SqKWb-!Bp6%a|el-xˬV" .N6{c=ɼ^TuvRbn ғCٞ_ ,16E7X)DGCH]/1-o>G􌃝Zvme5Yt_}Ҡ$<|;O . `$ u!#7}-ծ !e E'-er G^̓ z`e)-پOjrAUERFJ>؋vesCnotF R i ecLqf] )Bl5lp4B_}X-wWF-\{%"Z7Y#7hǕ!ݯAϻ+Tց~0]3&LtC% f d)rU tF+=giz6$z(ti8^  /۩^7zhh([ `g(w}076G5{|õaϸbTZr%,7,2fX,=f%HƇł%i/Jbrթz*]7 X]0cI -­|}xt@vlF@lua]:D-.yCEmKO]PV$nR-ܔ^'cz&6 *źR uvBpgSI]-$*^ha&F{~m]IL`*#:n˟6L2,=e&} aʰ$^UU8 t6ӮWBaE\GG[}̳TQWXV)=d;E75X]?ߥC lH9lKPWT; 3{4g_·[aa-!|uۭ'4v V؃s1ε쒯@_`.}~*4w9.6fwe]RQI[xi:y5TIbs*XBh< ,bX,bX,bX,b]P_O endstream endobj 230 0 obj <>stream HWou䮨 J)wi8)et" K)AAn%rjZڻ\jZ$tUoYO{ov\;zMOξ|޼ϼ7RZhZhZh_R+v kAڗREk۲,orLShl5X*Ű7)`ȳHr3sCL ^*_dCF@pq^3ӗ6rn9nL~WmD/gjT@g熘/Xe!lkHSc|bL ?fa۩ NP>Jz6TC><=g',$/00cс`mWaZ|vj̬jMdo!Rl 3c/Ok949HeZ-Z9#.E>,;>^"|wH#Zfek/Fx3Q〠k\Ķ0"z ,i1Cf'':~5]Sh)&?QC)˫ f&=0sQ*zyi&ɜsoS@lՀ 9`3^)4eF\bM#]_]T(nY6A1f CwȇbHpTIF8)eP?3ǺJ(5K^D 0xPU8 ^P"육j=Ȝ2[#.B2(X" ڸՂy(c}P-Rc3B6`cxM%Xo/`5![D F cB`5ŦM1mdvh,%tuLpC)]ST ifӯX޲+\ rT )x-x )^ rM׹&>8g0 [7H "V]/X(#Ujg`Ѯ3Yj)%J_a-y⽅wmMSQZCe S k!2`/ղj,M4JŸҸ¥.Ë,TXb́PMH@ N=5-oY:6Jfﰊcc_ O4@MQ1MUaQ*(جlMe ۴D7¼;XϤcw_[>'X#2īw1X}Y'Lxa:֠fS2Q䀂>}g|yęe,%ߦ'UEՏKc=f, fAL&I 3E?/_g<}F&^{+29hyf#@ tv {8VŽ_oO~&/ vx ,Y̪p^'Q&3@P_ |(ɼ3zON<㮼æT֒5ÂaBbaop^BXEZ.m(⒉:aeAQ-bs -1Fo >[bS&=o0ӁGT:f)`mU6P%aT##A F fK<5 `Ë { o 6TRV`Bۜ`c$7J(B -B -B -B -B m3?bL_[=338M1kms,[c,YDXUog fO.x9xj]irk~5;CaWߪhLFl-9/u0e:.4MOc-j 6T# l1f:LW`[&\CRKkZsJǿ`s ̧ vt]_X9Z !<[T5Vkf::n:U}&j1l'E+Ɖڷ SUҹ6_]#3rr,~v)_m`(Jz.~&90wqszqt?:cj$VnMt.%fUGVSG/$N?I=9[Œuj G$r<](Ϗ*xq(³5܁GO|7'G"C0ܕsoAdz~ꞁI8ҹN?<{ws>]mV_ի/#{Yz{2Y}bFNg61mDm^zԊt{n՛HS@ {S6`%|kD ^fD8VFkBoQ1?*ߣUU Lf6sY2nVƋ#fsyR&v. G{/:&֩Lv,n&x҅`~R|P9'isPlZ,Vv!1e:mu ă!j`F9%HBB9I 'Wμ׻cͼ7Uݿ_W;4pPckz|n-1ͭ9S1|0:K~+!-ا#1ׇTÖSm1̈́ W~ @sK{4kui}Ѷ#Ulu m+[5ֽ k**/Y5]کKdeE}.9ZzC `Lm7sVY"av9>|seksk{D.E>*4V§/|l&UҞ,f0^ k.ʥ=ﶏHE<{s)lU~.>PXல>howx)!?Zts?]滋,"|f)ĖӺ+ޛ.' AXq`OfJo|uW:(Ս(z[_ `l< 2 pV_P+(6G:V}vz!Ռ  7cնgo#j.X'ni^P9<]K%J|iʥ]>`[B;omA QWؕ[[`ƣH"M;į[7滫}{v.ñlXEvv&waq+zE֖u\/=:f]VŜ^a9?Mvu{3T0V&홿 k;\`~q)r@ cG3+vu97\ԏrdbX'yDfHFG, biim·O~xX@*juՕŭAf~,1`7a1iqCs8,ˠ/  }`  #d 2*|kwVΖ{h,%xi'hF' qOOkl7G8|ڤt2^ֲSr64L"jг\'͂Uf[Ə$ &`C焎ad TX[bd1 hkLv' Vϡl[S'X& hf)o{`gTmQ0`d' W@2Y`TVPs:bs=/4 Ul =fllK`cHmw;[,?G(.`;\eQ>-1 CqhKM-Z?\ 3 tr!x:ܪѲW4 <;$N&k[;~`Y,XɶMngR!\'26)fĂ 0_T_~,PLӀ.zkW`,pl2[aAgq XoI Wشf-RV/ CC=$˄7(c}K+`S`]"- bb7Mgμ`UGDJ *D N`%X1 ĵ]`J+先3B.LRO;>hVkAvH:99x!e8лS"4Fz47~Xzfǚ>6 N pO`h}o@=e#CVQAlUnp?w(%VK;, @c䥝л%Ý_]}nе6ꪰAI VjZ⪪3B P^ߣۧ%&hh&H -h`h9~*ea/"ء*ÏٱNOl%!E=$u|kڎ )ִ5k i ;<0L]͗D'Frǒ4 ԗn_=/rWxF!ɋ%8NN!-)A >FNI𾣘/qn&#%A XB"RU]?^UwOW4Sc}UIg֌g[xUAА6,em5=D AGv9b_"g҂`,QX FA`2pBffD/ۂϔ% MD^o2`B+J[M2+X%r&NxE1nM"=p0H;y ڸQ֋Ƶ25d)|Σ.f QSC=夅$ W> D`E(Ʒ ~ij VK+A+JXB:Y5, 5g37wyϔD b tm6[f oojy5tQ/46+Y%x"d5m~cIuW e״qց`] Im;ΣDjXBгPRy4yML$&G ]~K]Sba4!N/K:NkzycYq(:܍Ob /燴 pݵZ`ڑ8H4<*Kl`7CsO5'RYz909M6=܄ |v$vC8Rl]U]3 i;ΫM?at^Ap{.[9 MPl8= V䔖MWiNf<\Uc"6o%A.$ӜP Cc(E,X2V7=Lfgcf475Lma&hHa!tO?g%vOմ4,6.,[LMA7.C`A 6"0) v7-Ru"mO?^lB`=+A$HKeD9CldxQK=%]y nn:hv%rf0J7eș hıK,93,X `e0 Bт ڬHbSeih+oy9ŶA;`M5kT6ZZ$o<F.P8ĥ*Po Y瑚ۂD'du99Q6٨@n $QiZhp;@ujpG$LƩ3&j ZB$z$z/085,H Jy`veVx֋ 6oލ`[@D&XEmcbW 9-G߰8g[& 6)u-~#Ckj&tnMll|x]">T@ Q;C8=qDW;,&՝(s@QM^N]P  Jb;Y3(/H,zNkO'6GnDpF4Zɢ/KM"ʗ8> 6o",~ `-X/V8^ɏi%PBnR?pX^].j; ͔AHr$Haβ8NjƅFnL% XS%K ,QX FA`2` 1,w7]N \;/gz*km 6S$' i6}3x ܠD.\aT3 Qv#t;38=uMz{EvܾviG⧜ǣP46K5]͡acD;e֘b$`#@`J`ݛx?l`*F&7h{[#I(D^^ש5͎zBfm qv[36h<f@{O P:6[b=}'y)#%_Č.~+S C Im'$ܓGsI0/S4Y_ nthY>`2}p5=șH8Z`A_"g҂`,QX FA`2`,QX FA`2`,QX FA`2`,QX FAHO>.э 1߶& =˪Oa~W3!f㉼+Ƿ~|C5ܙ晸FthFf陘Iw_SOwɛz 7:tWOU972~r]ޯN^T* u'צg8$(J On`o<_\I=zpzx=[5=wwػSY;OvlY(} Ԣy:^-˻z$zm=bӂ=`jg^ܔ*ѡZ3_L/y~$%hbR:@ <Ղ@rMS%X9bk1TY(*yE+?8ޱjO옪c]]=W'Js^?Rl-uU[ >7G~<|`:؟IO'r5^L>YngDC˻Ӊi\e|two!7KOOcd syj~?d 5JSxaX5 ,kX3$Ś!1,֘8'eN Ϝj[BNF gMFݙig(D Y;2Ndt$ k(1)݌&cepBI1vLҸJkwD,>h$;> ֈGp<"j8 R[ˀ?KǛ0tʳ ;^.ǒoqOi(V%|Ȯ:;dua%[Me5 vFH)^`|ظXvOJ]"د'd=Jn ^2X =b`'Sڙ2Wwː/c {\A;6sWo"d(:/.``Y3(IL4hUUQA*B2W M[oMKI,nXq7`K1ɻ9+j'ú rx;iN|t̚{)G ge?Fy?G|Ѹuչd֟) SJH;S j4XutC9R ,km3Ce͐L4`]6*5]XkxG}u8s}BBDCul/(R3R2s៌ \{ao4jgq(?~J>Ԑ.I}BJ)C"Wl&A ^,BY*Vu,|=+d<#BGofM 5lʝI{*CZs3`P`PAgu2>;](eTX,ze+fM`{+y ׀v)kmF3 Y0 u&2 gX2#(}D4Ý-;s*J3 {!J+r{pc <ŊiQ$>Xk"ݑaURJ~{03rmO(}xqf2#[ U-Hkg}eؠ%"E$q쎜bbMLmBzZ,xo/e 7iUxNU1x_mVRnT1]Z. ``zS Oqk'`[mrF/Yj|ok5T}UCr 씪d]%yT]|>stream endstream endobj 265 0 obj <>stream ~}|yxwvutsrqonmlkjihgfeba_^]\[ZYXWUTSRQPONMLKIHGFEDCBA@?<;:97654210/.-,+)('"!   endstream endobj 225 0 obj [/Indexed/DeviceCMYK 216 266 0 R] endobj 263 0 obj <>stream endstream endobj 266 0 obj <>stream qba0?~{zyxwvutsrqnmjihgfedcba_^]\[ZYXWVUTRQPNMLKJIHFEDCBA@?><;:98765320/-,+)('$#"!  endstream endobj 224 0 obj [/Indexed/DeviceCMYK 210 267 0 R] endobj 262 0 obj <>stream endstream endobj 267 0 obj <>stream p}a|zyxwvutsrqonmlkihgfedcba_^][ZYXWVUTRQPONMLKJIHFEDCBA@?<;986543210/.-,+*('#"!   endstream endobj 223 0 obj [/Indexed/DeviceCMYK 202 268 0 R] endobj 261 0 obj <>stream endstream endobj 268 0 obj <>stream qpi?ba~}|{xvutsrqponmlkjihfedcb`_]\[ZXWVUTSRPOMLKJIGEDBA@?>=:986421+*)('%$  endstream endobj 71 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 72 0 obj <>/ExtGState<>/Font<>/ProcSet[/PDF/Text]/Properties<>/Shading<>/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 73 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 74 0 obj <>/Font<>/ProcSet[/PDF/Text]/Properties<>/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 75 0 obj <>/Font<>/ProcSet[/PDF/Text/ImageC]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 279 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\034\002\016\201\220\n)-9.9(\026)10.9(\025\002\020 \001\016\f\007\013\202)10(\025\221\002\220\205\026\001\025\202)10.1(\025 \220\006\207\025\201\013 \026)11(\016\002\013\221\220\220 )]TJ 0 -1 TD [(\n)10(\025\002\026\220\n)10(\025\006)-9.9(\026)11(\016\002\025\220\201\013\024\220 \215\022\221\013\227\220\016\001\026)11.1(\025\r \006\022\026\205\217\016\007\025\203 \013\026)11(\013\n)10(\025\203 \205\222\r\016\001\001\025\202)10.1(\025 )]TJ T* [(\n)10(\025\007\220\026)11(\013 \(\006\220\006)-10(\026)11(\016\024\013\026\220\017\016\006\n\220\203 \025\f\222\025\002 \220\022\024\ \016\026)11.1(\013\013\001\013\007\220\222\))]TJ 35.009 2 Td [(Pr)31(edictor)20.1(s of adv)12(er)20(se outcomes of ster)20(oids in patients with se)11(v)12(er)31(e )]TJ 3.699 -1 Td [(ulcer)21(ativ)12.1(e colitis \(s)10(y)10(stematic r)31(e)11(vie)11(w and meta-analy)10(ses\))]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0.118 Tw 10 0 0 10 288.6606 383.8459 Tm (\027\026)Tj /Span<>> BDC ( )Tj EMC (4,1 \020/\035 \(95% \212\222: )Tj 0 Tw (\257)Tj 0.118 Tw (4,5)Tj /Span<>> BDC ( )Tj EMC (\227 )Tj 0 Tw (\257)Tj 0.118 Tw (3,7\), \023\024)Tj /Span<>> BDC ( )Tj EMC (\f\030\026\r\027\036\027\017\033 )Tj 0.28 Tw 0 -1.218 TD (\f)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\024\005 \220\235\235\036\022\021\017\r\027\024\005 \ \021\036\030\026\023\017\017 \022\024\030\021\017\022\024\f\021\036\030\024\ )Tj 0 Tw (-)Tj 0.223 Tw T* (\017\007\026\n\017, \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\f\021\026\r\017\035 29 \017)Tj /Span<>> BDC ( )Tj EMC (33 \020/\035, \f\024\024\021\r\036\021\f\021\r\036\027\027\024, )Tj /T1_2 1 Tf 0 Tw T* (p)Tj /T1_1 1 Tf 0.05 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,00001. \206\036\021\036\030\024\020\036\027\027\024\f\021\034 \023\030\ \017)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\n \f\021\026\021\017\f\021\017\004\036)Tj 0 Tw (-)Tj T* (\f\022\017 \027\026\004\017\n\026: \(I)Tj 5.83 0 0 5.83 352.1094 338.4639 Tm (2)Tj 10 0 0 10 355.0244 335.1339 Tm (\))Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (66%, )Tj /T1_2 1 Tf (p)Tj /T1_1 1 Tf /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (0,0001 \(\217\017\f.)Tj /Span<>> BDC ( )Tj EMC (3\).)Tj -0.012 Tw -8.006 -1.218 Td [(\203\026 )0.5(3 )0.5(\f\031\021\022\017 )0.5(\035\036\004\036\027\017\016 )0.5(\r\t\016\r\035\036\027\027\026\016 )0.6(\021\036\027\007\036\027\006\017\016 )0.6(\023\024)]TJ /Span<>> BDC ( )Tj EMC 19.003 0 Td (\031\030\024\r\027\033 )Tj 0.085 Tw -19.003 -1.218 Td [(\026\035\034\002\031\n\017\027\026 )0.6(\f\024\b\030\026\027\016\035\026\f\034. )0.6(\230\026\022, )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 13.146 0 Td [(\020\030\031\023\023\036 )0.6(\020\024\030\n\024\027\026\035\034\027\024\005 )]TJ 0.388 Tw -13.146 -1.218 Td [(\030\036\017\f\021\036\027\021\027\024\f\021\017 )0.5(\031\030\024\r\036\027\034 \026\035\034\002\031\n\017\027\026 \002\t\035\ \f\021\026\021\017\f\021\017)]TJ 0 Tw (-)Tj 0.073 Tw T* (\004\036\f\022\017 \027\026\004\017\n\024 \027\017\032\036, \r)Tj /Span<>> BDC ( )Tj EMC (\f\030\036\007\027\036\n, \027\026)Tj /Span<>> BDC ( )Tj EMC (4,3 \020/\035 \(95% \212\222: )Tj 0 Tw T* (\257)Tj 0.105 Tw (5,5)Tj /Span<>> BDC ( )Tj EMC (\227 )Tj 0 Tw (\257)Tj 0.105 Tw (3,2\), \004\036\n \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\220\235\235\036\022\021\017\r\027\024\005 \021\036\030\026)Tj 0 Tw (-)Tj 0.08 Tw T* (\023\017\036\005 \022\024\030\021\017\022\024\f\021\036\030\024\017\007\026\ \n\017: 25,5 \017)Tj /Span<>> BDC ( )Tj EMC (30 \020/\035, )Tj /T1_2 1 Tf 0 Tw (p)Tj /T1_1 1 Tf 0.08 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,00001. )Tj -0.062 Tw T* (\206\036\021\036\030\024\020\036\027\027\024\f\021\034 \027\036 \r\t\016\ \r\035\036\027\026: \(I)Tj 0 Tw 5.83 0 0 5.83 403.4498 253.2179 Tm (2)Tj -0.062 Tw 10 0 0 10 406.3648 249.8879 Tm (\))Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0%, )Tj /T1_2 1 Tf 0 Tw (p)Tj /T1_1 1 Tf -0.062 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,8 \(\217\017\f.)Tj /Span<>> BDC ( )Tj EMC (4\).)Tj 0.134 Tw -13.14 -1.218 Td (2\))Tj /Span<>> BDC [( )-133( )]TJ EMC 1.37 0 Td (\211\030\024\r\036\027\034 \221-\030\036\026\022\021\017\r\027\024\020\024\ \002\036\035\022\026 \023\036\030\036\007 \027\026\004\026\035\024\n \035\ \036)Tj 0 Tw (-)Tj -0.003 Tw T* (\004\036\027\017\016 \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \020\024\030\n\024\027\026\035\034\027\024\005 \ \030\036\017\f\021\036\027\021\027\024\f\021\017 \002\t\035 )Tj 0.083 Tw T* [(\r\t\001\036, \004\036\n )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC [(\020\030\031\023\023\036 \220\235\235\036\022\021\017\r\027\024\005 \021\ \036\030\026\023\017\017 )0.5(\022\024\030\021\017)]TJ 0 Tw (-)Tj 0.12 Tw T* (\022\024\f\021\036\030\024\017\007\026\n\017, \r)Tj /Span<>> BDC ( )Tj EMC (\f\030\036\007\027\036\n, \027\026)Tj /Span<>> BDC ( )Tj EMC (33,3 \n\020/\035 \(95% \212\222: )Tj 0.042 Tw T* [(29,9\22636,7\) )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 5.363 0 Td [(\f\024\f\021\026\r\017\035 )0.6(74 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 6.025 0 Td [(43 )0.5(\n\020/\035, )0.6(\f\024\024\021\r\036\021\f\021\r\036\027)]TJ 0 Tw (-)Tj -11.388 -1.218 Td (\027\024, )Tj /T1_2 1 Tf 1.437 0 Td (p)Tj /T1_1 1 Tf 0.008 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0001. \206\036\021\036\030\024\020\036\027\027\024\f\021\034 \023\030\017\ )Tj /Span<>> BDC ( )Tj EMC (\220\021\024\n \f\021\026\021\017\f\021\017\004\036)Tj 0 Tw (-)Tj -1.437 -1.218 Td (\f\022\017 \027\026\004\017\n\026: \(I)Tj 5.83 0 0 5.83 352.1094 167.9718 Tm (2)Tj 10 0 0 10 355.0244 164.6418 Tm (\))Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (90%, )Tj /T1_2 1 Tf (p)Tj /T1_1 1 Tf /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (0,00001 \(\217\017\f. 5\).)Tj 0.996 Tw -8.006 -1.218 Td (\203\026 3 \f\031\021\022\017 \023\030\024\r\024\007\017\n\024\020\024 \035\ \036\004\036\027\017\016 \031\030\024\r\036\027\034 )Tj 1.089 Tw T* (\221-\030\036\026\022\021\017\r\027\024\020\024 \002\036\035\022\026 \024\ \021\035\017\004\026\035\f\016, \r)Tj /Span<>> BDC ( )Tj EMC (\f\030\036\007\027\036\n, )Tj 0.325 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC (24,8)Tj /Span<>> BDC ( )Tj EMC (\(95% \212\222: 18,2\22631,4\) \n\020/\035, \023\024)Tj /Span<>> BDC ( )Tj EMC (\f\030\026\r\027\036\027\017\033 )Tj 0.493 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\024\005 \220\235\235\036\022\021\017\r\027\024\005 \ \021\036\030\026\023\017\017 \022\024\030\021\017\022\024\f\021\036\030\024\ \017)Tj 0 Tw (-)Tj 0.285 Tw T* (\007\026\n\017: 49 \017)Tj /Span<>> BDC ( )Tj EMC (25 \n\020/\035, \f\024\024\021\r\036\021\f\021\r\036\027\027\024, )Tj /T1_2 1 Tf 0 Tw (p)Tj /T1_1 1 Tf 0.285 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,00001. )Tj 0.303 Tw T* (\206\036\021\036\030\024\020\036\027\027\024\f\021\034 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\n \027\036 \r\t\016\r\035\036\027\026: \(I)Tj 0 Tw 5.83 0 0 5.83 459.2883 94.9039 Tm (2)Tj 0.303 Tw 10 0 0 10 462.2032 91.5739 Tm (\))Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0%, )Tj /T1_2 1 Tf 0 Tw -18.724 -1.218 Td (p)Tj /T1_1 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,7 \(\217\017\f.)Tj /Span<>> BDC ( )Tj EMC (6\).)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 9 0 0 9 42.5197 730.483 Tm (\020\004\206\f\t\204\004 1.)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf ( \216\013\023\007\006\031\021\021\020\031 \025\t\t\023\031\030\n\027\026\ \021\025\002)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0 -1.2 TD [(T)48(able 1)47(.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf ( Included studies)Tj ET 0 0 0 1 K 0.5 w /GS2 gs q 1 0 0 1 42.5197 715.181 cm 0 0 m 90.959 0 l S Q q 1 0 0 1 42.7697 703.9617 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 133.4783 715.181 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 133.4783 703.9617 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 181.6673 715.181 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 181.6673 703.9617 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 229.8563 715.181 cm 0 0 m 266.707 0 l S Q q 1 0 0 1 229.8563 703.9617 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 496.313 703.9617 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 42.5197 703.7117 cm 0 0 m 90.959 0 l S Q q 1 0 0 1 42.7697 692.5005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 133.4783 703.7117 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 133.4783 692.5005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 181.6673 703.7117 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 181.6673 692.5005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 229.8563 703.7117 cm 0 0 m 266.707 0 l S Q q 1 0 0 1 229.8563 692.5005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 692.5005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 692.2505 cm 0 0 m 90.959 0 l S Q q 1 0 0 1 42.7697 681.0392 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 133.4783 692.2505 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 133.4783 681.0392 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 181.6673 692.2505 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 181.6673 681.0392 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 229.8563 692.2505 cm 0 0 m 266.707 0 l S Q q 1 0 0 1 229.8563 681.0392 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 681.0392 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 680.7892 cm 0 0 m 90.959 0 l S Q q 1 0 0 1 42.7697 669.5779 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 133.4783 680.7892 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 133.4783 669.5779 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 181.6673 680.7892 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 181.6673 669.5779 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 229.8563 680.7892 cm 0 0 m 266.707 0 l S Q q 1 0 0 1 229.8563 669.5779 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 669.5779 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 669.3279 cm 0 0 m 90.959 0 l S Q q 1 0 0 1 42.7697 658.1166 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 133.4783 669.3279 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 133.4783 658.1166 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 181.6673 669.3279 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 181.6673 658.1166 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 229.8563 669.3279 cm 0 0 m 266.707 0 l S Q q 1 0 0 1 229.8563 658.1166 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 658.1166 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 657.8666 cm 0 0 m 90.959 0 l S Q q 1 0 0 1 42.7697 646.6553 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 133.4783 657.8666 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 133.4783 646.6553 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 181.6673 657.8666 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 181.6673 646.6553 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 229.8563 657.8666 cm 0 0 m 266.707 0 l S Q q 1 0 0 1 229.8563 646.6553 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 646.6553 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 646.4053 cm 0 0 m 90.959 0 l S Q q 1 0 0 1 42.7697 635.194 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 133.4783 646.4053 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 133.4783 635.194 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 181.6673 646.4053 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 181.6673 635.194 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 229.8563 646.4053 cm 0 0 m 266.707 0 l S Q q 1 0 0 1 229.8563 635.194 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 635.194 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 634.944 cm 0 0 m 90.959 0 l S Q q 1 0 0 1 42.7697 623.7328 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 133.4783 634.944 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 133.4783 623.7328 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 181.6673 634.944 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 181.6673 623.7328 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 229.8563 634.944 cm 0 0 m 266.707 0 l S Q q 1 0 0 1 229.8563 623.7328 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 623.7328 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 623.4828 cm 0 0 m 90.959 0 l S Q q 1 0 0 1 42.7697 612.2715 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 133.4783 623.4828 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 133.4783 612.2715 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 181.6673 623.4828 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 181.6673 612.2715 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 229.8563 623.4828 cm 0 0 m 266.707 0 l S Q q 1 0 0 1 229.8563 612.2715 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 612.2715 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 612.0215 cm 0 0 m 90.959 0 l S Q q 1 0 0 1 42.7697 600.8102 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 133.4783 612.0215 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 133.4783 600.8102 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 181.6673 612.0215 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 181.6673 600.8102 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 229.8563 612.0215 cm 0 0 m 266.707 0 l S Q q 1 0 0 1 229.8563 600.8102 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 600.8102 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 600.5602 cm 0 0 m 90.959 0 l S Q q 1 0 0 1 42.7697 589.3489 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 133.4783 600.5602 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 133.4783 589.3489 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 181.6673 600.5602 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 181.6673 589.3489 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 229.8563 600.5602 cm 0 0 m 266.707 0 l S Q q 1 0 0 1 229.8563 589.3489 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 589.3489 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 589.0989 cm 0 0 m 90.959 0 l S Q q 1 0 0 1 42.7697 577.8876 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 133.4783 589.0989 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 133.4783 577.8876 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 181.6673 589.0989 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 181.6673 577.8876 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 229.8563 589.0989 cm 0 0 m 266.707 0 l S Q q 1 0 0 1 229.8563 577.8876 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 577.8876 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 577.6376 cm 0 0 m 90.959 0 l S Q q 1 0 0 1 42.7697 566.4263 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 133.4783 577.6376 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 133.4783 566.4263 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 181.6673 577.6376 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 181.6673 566.4263 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 229.8563 577.6376 cm 0 0 m 266.707 0 l S Q q 1 0 0 1 229.8563 566.4263 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 566.4263 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 566.1763 cm 0 0 m 90.959 0 l S Q q 1 0 0 1 42.7697 554.9651 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 133.4783 566.1763 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 133.4783 554.9651 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 181.6673 566.1763 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 181.6673 554.9651 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 229.8563 566.1763 cm 0 0 m 266.707 0 l S Q q 1 0 0 1 229.8563 554.9651 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 554.9651 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 554.7151 cm 0 0 m 90.959 0 l S Q q 1 0 0 1 42.7697 543.5038 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 133.4783 554.7151 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 133.4783 543.5038 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 181.6673 554.7151 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 181.6673 543.5038 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 229.8563 554.7151 cm 0 0 m 266.707 0 l S Q q 1 0 0 1 229.8563 543.5038 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 543.5038 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 543.2538 cm 0 0 m 90.959 0 l S Q q 1 0 0 1 42.7697 532.0425 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 133.4783 543.2538 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 133.4783 532.0425 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 181.6673 543.2538 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 181.6673 532.0425 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 229.8563 543.2538 cm 0 0 m 266.707 0 l S Q q 1 0 0 1 229.8563 532.0425 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 532.0425 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 531.7925 cm 0 0 m 90.959 0 l S Q q 1 0 0 1 42.7697 520.5812 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 133.4783 531.7925 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 133.4783 520.5812 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 181.6673 531.7925 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 181.6673 520.5812 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 229.8563 531.7925 cm 0 0 m 266.707 0 l S Q q 1 0 0 1 229.8563 520.5812 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 520.5812 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 520.3312 cm 0 0 m 90.959 0 l S Q q 1 0 0 1 42.7697 509.1199 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 133.4783 520.3312 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 133.4783 509.1199 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 181.6673 520.3312 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 181.6673 509.1199 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 229.8563 520.3312 cm 0 0 m 266.707 0 l S Q q 1 0 0 1 229.8563 509.1199 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 509.1199 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 508.8699 cm 0 0 m 90.959 0 l S Q q 1 0 0 1 42.7697 497.6586 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 133.4783 508.8699 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 133.4783 497.6586 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 181.6673 508.8699 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 181.6673 497.6586 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 229.8563 508.8699 cm 0 0 m 266.707 0 l S Q q 1 0 0 1 229.8563 497.6586 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 497.6586 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 497.4086 cm 0 0 m 90.959 0 l S Q q 1 0 0 1 133.4783 497.4086 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 181.6673 497.4086 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 229.8563 497.4086 cm 0 0 m 266.707 0 l S Q BT /GS1 gs /T1_3 1 Tf 8 0 0 8 77.8801 706.5463 Tm (\032\003\002\006)Tj 9.198 0 Td (\027\002\240)Tj 4.848 0 Td (\026\013\206\002\006\220\004)Tj 16.379 0 Td (\034\213\210\201\004\r\214\013\r \212\006\r\240\t\220\003\002\006\013)Tj /T1_1 1 Tf -34.459 -1.433 Td (Han et al. [9])Tj 12.996 0 Td (2014)Tj 6.524 0 Td (62)Tj 5.615 0 Td (\202\035\034\002\031\n\017\027, \221-\030\036\026\022\021\017\r\027\t\005\ \002\036\035\024\022, \020\036\n\024\020\035\024\002\017\027, \220\027\007\ \024\f\022\024\023\017\004\036\f\022\026\016 \022\026\030\021\017\027\026\ )Tj -25.135 -1.433 Td (Corte et al. [10])Tj 12.996 0 Td (2015)Tj 6.524 0 Td (89)Tj 14.817 0 Td (\224\027\007\024\f\022\024\023\017\004\036\f\022\026\016 \022\026\030\021\ \017\027\026)Tj -34.337 -1.433 Td (Gibson et al. [11])Tj 12.996 0 Td (2017)Tj 6.274 0 Td (124)Tj 14.011 0 Td (\202\035\034\002\031\n\017\027, \221-\030\036\026\022\021\017\r\027\t\005\ \002\036\035\024\022)Tj -33.281 -1.433 Td (Xie et al. [12])Tj 12.996 0 Td (2017)Tj 6.274 0 Td (117)Tj 5.865 0 Td (\202\035\034\002\031\n\017\027, \221-\030\036\026\022\021\017\r\027\t\005\ \002\036\035\024\022, \020\036\n\024\020\035\024\002\017\027, \220\027\007\ \024\f\022\024\023\017\004\036\f\022\026\016 \022\026\030\021\017\027\026\ )Tj -25.135 -1.433 Td (Jain et al. [13])Tj 12.996 0 Td (2017)Tj 6.524 0 Td (49)Tj 5.615 0 Td (\202\035\034\002\031\n\017\027, \221-\030\036\026\022\021\017\r\027\t\005\ \002\036\035\024\022, \020\036\n\024\020\035\024\002\017\027, \220\027\007\ \024\f\022\024\023\017\004\036\f\022\026\016 \022\026\030\021\017\027\026\ )Tj -25.135 -1.433 Td (Choy et al. [14])Tj 12.996 0 Td (2018)Tj 6.524 0 Td (54)Tj 5.615 0 Td (\202\035\034\002\031\n\017\027, \221-\030\036\026\022\021\017\r\027\t\005\ \002\036\035\024\022, \020\036\n\024\020\035\024\002\017\027, \220\027\007\ \024\f\022\024\023\017\004\036\f\022\026\016 \022\026\030\021\017\027\026\ )Tj -25.135 -1.433 Td (Xie \(2\) et al. [15])Tj 12.996 0 Td (2018)Tj 6.524 0 Td (92)Tj 12.612 0 Td (\202\035\034\002\031\n\017\027, \220\027\007\024\f\022\024\023\017\004\036\ \f\022\026\016 \022\026\030\021\017\027\026)Tj -32.132 -1.433 Td (Dalal et al. [16])Tj 12.996 0 Td (2019)Tj 6.274 0 Td (440)Tj 5.865 0 Td (\202\035\034\002\031\n\017\027, \221-\030\036\026\022\021\017\r\027\t\005\ \002\036\035\024\022, \020\036\n\024\020\035\024\002\017\027, \220\027\007\ \024\f\022\024\023\017\004\036\f\022\026\016 \022\026\030\021\017\027\026\ )Tj -25.135 -1.433 Td (Ghoshal et al. [17])Tj 12.996 0 Td (2020)Tj 6.274 0 Td (263)Tj 11.315 0 Td (\202\035\034\002\031\n\017\027, \221-\030\036\026\022\021\017\r\027\t\005\ \002\036\035\024\022, \020\036\n\024\020\035\024\002\017\027,)Tj -30.585 -1.433 Td (Grant et al. [18])Tj 12.996 0 Td (2020)Tj 6.274 0 Td (235)Tj 11.408 0 Td (\202\035\034\002\031\n\017\027, \221-\030\036\026\022\021\017\r\027\t\005\ \002\036\035\024\022, \020\036\n\024\020\035\024\002\017\027)Tj -30.678 -1.433 Td (Atia et al. [19])Tj 12.996 0 Td (2021)Tj 6.274 0 Td (153)Tj 14.011 0 Td (\202\035\034\002\031\n\017\027, \221-\030\036\026\022\021\017\r\027\t\005\ \002\036\035\024\022)Tj -33.281 -1.433 Td (Sahu et al. [20])Tj 12.996 0 Td (2021)Tj 6.524 0 Td (40)Tj 5.615 0 Td (\202\035\034\002\031\n\017\027, \221-\030\036\026\022\021\017\r\027\t\005\ \002\036\035\024\022, \020\036\n\024\020\035\024\002\017\027, \220\027\007\ \024\f\022\024\023\017\004\036\f\022\026\016 \022\026\030\021\017\027\026\ )Tj -25.135 -1.433 Td (Tanaka et al. [21])Tj 12.996 0 Td (2021)Tj 6.524 0 Td (95)Tj 11.158 0 Td (\202\035\034\002\031\n\017\027, \221-\030\036\026\022\021\017\r\027\t\005\ \002\036\035\024\022, \020\036\n\024\020\035\024\002\017\027)Tj -30.678 -1.433 Td (Syal et al. [22])Tj 12.996 0 Td (2021)Tj 6.524 0 Td (63)Tj 13.761 0 Td (\202\035\034\002\031\n\017\027, \221-\030\036\026\022\021\017\r\027\t\005\ \002\036\035\024\022)Tj -33.281 -1.433 Td (Jain S. et al. [23])Tj 12.996 0 Td (2021)Tj 6.524 0 Td (76)Tj 5.615 0 Td (\202\035\034\002\031\n\017\027, \221-\030\036\026\022\021\017\r\027\t\005\ \002\036\035\024\022, \020\036\n\024\020\035\024\002\017\027, \220\027\007\ \024\f\022\024\023\017\004\036\f\022\026\016 \022\026\030\021\017\027\026\ )Tj -25.135 -1.433 Td (Baut et al. [24])Tj 12.996 0 Td (2021)Tj 6.274 0 Td (270)Tj 5.865 0 Td (\202\035\034\002\031\n\017\027, \221-\030\036\026\022\021\017\r\027\t\005\ \002\036\035\024\022, \020\036\n\024\020\035\024\002\017\027, \220\027\007\ \024\f\022\024\023\017\004\036\f\022\026\016 \022\026\030\021\017\027\026\ )Tj -25.135 -1.433 Td (Adams et al. [25])Tj 12.996 0 Td (2022)Tj 6.274 0 Td (131)Tj 5.865 0 Td (\202\035\034\002\031\n\017\027, \221-\030\036\026\022\021\017\r\027\t\005\ \002\036\035\024\022, \020\036\n\024\020\035\024\002\017\027, \220\027\007\ \024\f\022\024\023\017\004\036\f\022\026\016 \022\026\030\021\017\027\026\ )Tj -25.135 -1.433 Td (Con et al. [26])Tj 12.996 0 Td (2022)Tj 6.524 0 Td (94)Tj 13.761 0 Td (\202\035\034\002\031\n\017\027, \221-\030\036\026\022\021\017\r\027\t\005\ \002\036\035\024\022)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 9 0 0 9 42.5197 480.6893 Tm (\020\004\206\f\t\204\004 2.)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf ( \206\026\032\026\013\024\031\032\025\t\024\025\013\026 \033\026\203\025\ \031\021\024\n\027)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf T* [(T)48(able 2)16(.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf [( Character)-36.9(istics of patients)]TJ ET /GS2 gs q 1 0 0 1 42.5197 465.3874 cm 0 0 m 110.801 0 l S Q q 1 0 0 1 42.7697 454.1682 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 153.3209 465.3874 cm 0 0 m 85.039 0 l S Q q 1 0 0 1 153.3209 454.1682 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 238.3602 465.3874 cm 0 0 m 172.913 0 l S Q q 1 0 0 1 238.3602 454.1682 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 411.2736 465.3874 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 411.2736 454.1682 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 453.7933 465.3874 cm 0 0 m 42.77 0 l S Q q 1 0 0 1 453.7933 454.1682 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 496.313 454.1682 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 42.5197 453.9182 cm 0 0 m 110.801 0 l S Q q 1 0 0 1 42.7697 442.7068 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 153.3209 453.9182 cm 0 0 m 85.039 0 l S Q q 1 0 0 1 153.3209 442.7068 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 238.3602 453.9182 cm 0 0 m 172.913 0 l S Q q 1 0 0 1 238.3602 442.7068 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 411.2736 453.9182 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 411.2736 442.7068 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 453.7933 453.9182 cm 0 0 m 42.77 0 l S Q q 1 0 0 1 453.7933 442.7068 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 442.7068 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 442.4568 cm 0 0 m 110.801 0 l S Q q 1 0 0 1 42.7697 431.2456 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 153.3209 442.4568 cm 0 0 m 85.039 0 l S Q q 1 0 0 1 153.3209 431.2456 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 238.3602 442.4568 cm 0 0 m 172.913 0 l S Q q 1 0 0 1 238.3602 431.2456 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 411.2736 442.4568 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 411.2736 431.2456 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 453.7933 442.4568 cm 0 0 m 42.77 0 l S Q q 1 0 0 1 453.7933 431.2456 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 431.2456 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 430.9956 cm 0 0 m 110.801 0 l S Q q 1 0 0 1 42.7697 419.7843 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 153.3209 430.9956 cm 0 0 m 85.039 0 l S Q q 1 0 0 1 153.3209 419.7843 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 238.3602 430.9956 cm 0 0 m 172.913 0 l S Q q 1 0 0 1 238.3602 419.7843 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 411.2736 430.9956 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 411.2736 419.7843 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 453.7933 430.9956 cm 0 0 m 42.77 0 l S Q q 1 0 0 1 453.7933 419.7843 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 419.7843 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 419.5343 cm 0 0 m 110.801 0 l S Q q 1 0 0 1 42.7697 408.323 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 153.3209 419.5343 cm 0 0 m 85.039 0 l S Q q 1 0 0 1 153.3209 408.323 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 238.3602 419.5343 cm 0 0 m 172.913 0 l S Q q 1 0 0 1 238.3602 408.323 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 411.2736 419.5343 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 411.2736 408.323 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 453.7933 419.5343 cm 0 0 m 42.77 0 l S Q q 1 0 0 1 453.7933 408.323 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 408.323 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 408.073 cm 0 0 m 110.801 0 l S Q q 1 0 0 1 153.3209 408.073 cm 0 0 m 85.039 0 l S Q q 1 0 0 1 238.3602 408.073 cm 0 0 m 172.913 0 l S Q q 1 0 0 1 411.2736 408.073 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 453.7933 408.073 cm 0 0 m 42.77 0 l S Q BT /GS1 gs /T1_3 1 Tf 8 0 0 8 76.6495 456.7528 Tm (\200\r\006\r\214\r\b\b\004\235)Tj 10.181 0 Td (\021\002\f-\002 \t\217\217\f\r\240\002\004\b\t\005)Tj 16.722 0 Td (\026\r\f\t\201\t\b\004 \234\226\226\r\220\003\004)Tj /T1_4 1 Tf 17.323 0.001 Td (\n)Tj /T1_3 1 Tf 5.237 -0.001 Td (I)Tj 4.664 0 0 4.664 475.1606 459.4168 Tm (2)Tj /T1_1 1 Tf 8 0 0 8 45.6043 445.2915 Tm (\215\024\035 \(\n\031\032\f\022\024\005\))Tj 18.28 0 Td (17)Tj 10.504 0 Td (\210\234)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (1,02; 95% \212\222: 0,84\2261,24)Tj 18.99 0 Td (0,8)Tj 5.278 0 Td (0%)Tj -53.052 -1.433 Td (\200\024\030\026\f\021 \(\035\036\021\))Tj 18.28 0 Td (17)Tj 8.279 0 Td (\217\026\027\017\006\026 \f\030\036\007\027\017\b)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,58; 95% \212\222: \2578\2261,9)Tj 21.215 0 Td (0,4)Tj 5.028 0 Td (58%)Tj -52.802 -1.433 Td (\212\035\017\021\036\035\034\027\024\f\021\034 \026\027\026\n\027\036\026\ \(\035\036\021\))Tj 18.28 0 Td (12)Tj 7.936 0 Td (\217\026\027\017\006\026 \f\030\036\007\027\017\b)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,13; 95% \212\222: \2570,3\2260,5)Tj 21.558 0 Td (0,5)Tj 5.028 0 Td (46%)Tj -52.802 -1.433 Td (\230\024\021\026\035\034\027\024\036 \023\024\030\026\032\036\027\017\036\ )Tj 18.28 0 Td (11)Tj 11.597 0 Td (\210\234)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (1,5; 95% \212\222: 1,1\2262)Tj 17.397 0 Td (0,006)Tj 5.528 0 Td (36%)Tj ET q 42.52 100.996 221.102 279.316 re W n q /GS0 gs 221.1023475 0 0 279.438808 42.5196833 100.8737102 cm /Im0 Do Q Q BT 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf -0.038 Tw 9 0 0 9 42.5197 90.1959 Tm [(\022\t\217\210\b\002\220 )0.5(2.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf [( \212\025\t\013 )0.5(\t\025\t\024\031\003\026\024\025\006\031\t\013\n\017 )0.6(\n\001\025\005\013\025 )0.5(\027)]TJ /Span<>> BDC ( )Tj EMC 18.554 0 Td (\025\t\t\023\031\030\n\027\026\021\025\002\004)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0 Tw -18.554 -1.2 Td [(F)-16(igure 2)16.1(.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf ( Risk of bias in studies)Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\214)10(\211\036\033 \035\030\032\t\033)30(\b)42(\032)-21(\240\033\233)]TJ 57.136 0 Td (REVIEW)Tj /T1_5 1 Tf 25 0 0 25 505.5021 56.0378 Tm (175)Tj ET endstream endobj 280 0 obj <>stream Adobed     '$''''$25552;;;;;;;;;;   ####''',,,   ####''',,,   ####''',,,G""  !1Qa"2Aq$B#cR %&'()*3456789:CDEFGHIJSTUVWXYZbdefghijrstuvwxyz q!1A"Qaq2B3Rr#$b4T CSs %&'()*56789:DEFGHIJUVWXYZcdefghijtuvwxyz?QGADDAADDADDAADDADDAADDADDAADDADDAADDADDAADDADDAADDĝPiM@-TkZ\lH/xb:F2E-3J (@npѧe*G/RU!dH2V  ԛF:BJ)Nzrh#E?IJiuz!hiUխAB)`WUҀBN r J%g_!a"(tFBJIJYaV;Z#a7KHgIFW?P& "KTzL3;AѥZ9ʑ.dPeu5ItS5-X%bVxTXGDQ NH6~ty:9GR6H3% K:t JA1 196fgH>f$)j LR֮V؂""H#:@ QD3 ‰LIv_G?uE}i=iEH@QiI$ .툠tt,9]ZT_T)N1n}!R%Kz2 @OTV?N΢J$P|<FW>C2:;B.b u4Z`tl߼#3qd}! J hd!Tՠ c "T-:-8L%(V" It w)Z3G% AbJ6 *nRTA&F] +딕 Ԡ%0QMTLɋZK^Sl 2@E.H$ P*^F , #Ϸ_Dj+ђu+dH$97,ɔPY (()\RxsKQ-+jRY:YOivZ)Z(!+MWJ R4""ɟ2"~T-b,lkJM4Q*dS*TT*QWEYfOWIi$7J` ,!o}őX=#|J" -],&})$@mȅNQDBPdX9̈́} iQ'<&Z I "( K4Tn'i[-#)MC 䈈0<IGbi53NEr$$beu[D!l5t"" }őX$*u%h$ՠ 9b"1,IDS%欉˔E(V0DDA\h)r|t!ppLRԅ$H,RemBld3tiU&u)+*!ekLtÖfUz]DDAtGhgJQ2jBVoqq ,?og'FGFIԯRK inM'7$34YJ(C{9s%l5i&ig)oMKA zA97G 2ND ()rri azR e@RvnE># &L3CLWԄiY lx΂""[=EIZ NЯ>FH}hRBPDDA%*R:XëI%#ri}QՄW_Rz6v_Hj )1u( $O'3'F)@ԩ]i閂(CR`3IGbњ)IJ|%icI)\lt>YS'Lz!j=!@nRMC#*oA3&t|-Qi|T,зi>F֘J󕩕:z?j?ʣy]D2e۬d-a+=Q)] !Y_FjEHJa`JV%IDDQUG>GTn:6~+T,3&%) IbGT}9TwY1zT-I@dLRI$ SuZiB}BIJSP(|G>GTh=Qi2&*ufa ҂CT98DզJD%jKRl-6.\u62zޙirO ;͠nWB>\5 XTɄ+Z4G %$|W?۹9ӗ z9{:&LnI\ى)JN.WrKF|]c$-i'%! 㲾se?Zt ֍JFJ}D0v*TLؤI-`O95 3\hDa|拣'1RW($iVWѓĽD碕xVP ۰uCtl ''Q)HP|c#2~W J(O@ѢU}5O¢C#@Hk%z6\ :Ea`V*栣)/g~): Mm- D3 U7K>}u zfW>ΖCu'%zC^talץ7f%{'֝-)B+1]okS ?w+t*K&ԙH$d$7 #x25Zr湔̘ .DZAة( K|i/PiKr BpftsvH'[r\״99F cb-B_Sr-@ scr2 r48 ngFPA+HP@,w[)zK $Y[9kL?ʧʔI<4*wGkNRE#RdjW2v@guh)ZK7Z)&t! O[)I9y""-Xҍ-'E+F!I ^Fќ=qiVJj} kGb sgONr4rΨ()D,Cl:~QDYJ % DUJ΍+=\m$L„J2k~6ZfB4Һ sfPQ$$w؂#N/f#VEkĬku.\ʟ螔'-D H.8cm4k:^n) )eZ6Y,ևMP ~ FVVtxY"k&txW, YJ"!xQ1sQH>vxitJW5ܸÖVI'ed$#5?EEZ4piҐT8B\7 Qh$j$-'wJЯ[.%LXJ<%*5،a^WApثi9-}sxesl0x}UOPT*~4ul}ҫML3bʗ2bb pԕ/OJCP,$\RQ6֍ԠYϞ#j/QBTi'$lw;z3ݑsD%"r5OT>j%JA*TNPJXqqE-yzi4:.fTj ZvZ1,t3N5/C(MuVLЅ֐l1"-XэMGWh !pJ?Q?F&{qQ|FFܹpZT~"ѫNN-h;V9%܋a|zgN@%(KH`sh]?M(N*=r-j(H1(Tti_V ttZtS^H Z٠"%'zSQZ9Ӕ]hP1SE0N}#g "GB30,njp`hOI)E4L@RAqwb"Ght*RPk,dE CIqTO/cM6zi&t,h񐬅W:ML15<j);G*!:xnݔ^F$[[3Ӧ˸@$rb󓧔@l꾊+jѠӧBCMPb(OY N)J &N7&15t: ˶U:dse˔*qIZ$(\&q7Fz0$g'CVe3MbQPS,wc[1Y1 cYk9Zaԕ٘ص3SR$)1w-L2U{I%K.jyDq}%2.FF(IRR$*2Ԕ FFyL9 HUۈf?J*v~ LaYB'dZ=}e _)6*bgKDH#Ys5 Zp;72~W~x"B2RK, c &MBB1 N`V:?ěޏPX $uts L\g䛗8ܓ9Y/iKt`˛"@iyZGBƎ"-?3 ӀU*`~EAKvE|F1ҵQGADDAC_n5?CK*>O^j'K"eÇFA~LRjtAeyE*oD}G[;p"" HZfF\(1l急2ovxXN~M.g 8Ze]<{bAw?u (""a=54"`TsڍkQR)5p lA}(P'T$RU@3E]n< tqQDD%tPf!%:B& Y7debi^)RRKI໥a]n< tqQDDa!֪`KZ&LԵo=" JĹnJ@%ܒI=ηAw?u (""VRz򔊵ԂB LQ  (}ǝ8OD};c]&H9am"|je.L蘒;GC9prț/Z&IVpJ``h*GI"ZNS0&Tk}pH1Bbrs4g<<Y2V{O=90 d͏wW!Sw5Yo4u"~a9 8 A;Gti% rpeKZ(HJ q k4\Fu RA˔FS,1ZHuHԥa!9QU 9ǴP:Spɔ*XdKHHO&2^,`zW>ibJPj-/g~):9Tk}]-Rz n|Mg4-<WE=9F;ASEu[zc~LnbZKv^[ krIJԇecy: Wje))*J J.bAة Pgu:9ORf D`2wpĭTk}hh% 7Y]&z)$)A!e!Jdlm"[2 Nu4=lgi` "6 ws-k g얅ksH 1-bp+PBCR bn4 b`ɜ3P bqt*iDkxODk5ľI+Z7TxL!J#ŗ%E*\yTIiL:DsxҠspP"-hҊ+"~1':uI륲 i`"~awE#ܞ<7խj٧w1!-7O̫4;Y?e_=]\NiS1䤕'&x0jYr:q^\K ^aPNVKJkg)P$ʔ9D3 IpG8Rl|Ƕբj`\i]s]@h`!,- "辎򈖮bav\8KvD:`2.SJ *6*@5:LjZةdcs].rT'j6hdB3RFw #a_N.~\&3bX{h7GgO9P֍hh&-2ԩlҎ&KQ6He%.@$*KJt/؃qT 8891hκsPZ\06n]\'" 8&`]|~dY }Sw5Eky&~a5 A81->~tIYRd%>kQ BFDדT s'x*F$5Ipڀ^:LLjKu&`HNTd!IHQ@(0CSD_K*R$DD'#K!U!CUS&nK%.ĥ h]7KG>.B3x!c뾲1Bڈ$aiP91NXH*hheZ<bBRݗo<)$)KԇecqoauΘrQL;5*h3pzg!t&jBm:~_݃ |HFTkD(KTҰǟa!:RgT ~C1G/(a!FLԙs4ӭj EjHDJQz`\S=R~YR|-K k$&L:uFlPQ 7)C_RpFdt70mVb%'XS]1 ђ:1BQ$(Wv~4:/]=>|QӬ[.'USՅ)5)KSJ@'ZHѧ+tLJl$j5H%;IB/dV^QZdn$5(Jԁvá}#H \3ee%2Д 2P&ZRJ@vOg_SӪ:9EcS-JRLcp B^]MG(R`{Beͥ*CZ# tD(Z\yݵ2]:Ɛ S0d[!e;bVKt\zW(Z;)ȳj$h*1 0'椡T^ekz:~UHQ^em%\ЦRw}?y ƢJ L:iKY2rdt#p9Gn8u;adـM $ukΒ̞͖ AJtWBȑ4j"=ӵQGADDAC_n5?CK*>>kƧeGi(:PDDUDFlLLXz3`DpD+ZxJ%bRVUR%4bJř-B&KXZT h쾖%$T-Ku,S Q*@OV1(W)JVz+dMBeb\EzeSe.zMTSHIrFRdP:EamW}"" : @h(%ILĩiQ |^\tΩ*QSTM!HpQr?7QLSd<5 P30DTqQM:9wT&0PJTZ(IoDDں*Zתj i, ⩝ZSEtSSx>DrԕJ&\-3P4(fW"?j(i2tJ-jQ J(6"-GLRfO%IDšh)4&VTl KB˞L$ְV@gN͙*jMIM$J9Re̔( S9iYKAP.X=DH$]l場#3cba#=;!n-NSh ^+"rƝ,nv>܏˅tGunL )+4>Ҕ_Dn~ХN\'Z5y LLVI(R&^1RRhz֓Wgkg9{p  O _,umUyQFENDT %!STQE 5}<&tYP JLAC&Kh*Z3bWc'QDj`7R2I S:XK^n\#8Z0:{SD&4?Dv߷lFtjLM >EKXV${j)/g~):͖z}҅LOzŽh@;VaS0r/ζ UV|; @1& viZOROG)v،\4:y3YFH*'Y>g ieemwFi˗5&LŔeH;(,(͟$J\ʔ)JP (s7.Iz?T4ZsԒ *jU.bAؔ)@YNОJԽ4zLBTJc±!W}AScpSS9')7 8VHʎq&9A\1Ì.\NTy}ӝ.+eٚX#Ix ΐ($5gɦa|B1VYӅK{ ;ƯH t uWщDޱi-iUiԭvQꙢfZd H))QXJY1.驺=%j $֮kepK='p><%IZ0e ]!)IIQ,舾7?M'Z{Yi_Y=9i ֎ $5 5se]۴o~xAZ-8_҉Zuά,ԥPAE!; 4EGF}+"T:j3 JMYQt/IꤍDlDr&-$YA$ eW ͕"Z5:&Zf9T!)N|ΚJf-#Q ı9]=3#qb4]@h`gD1Ģa\Yx _x,f4L;)p NPQ nSt󖊆(vFڭP2rYYMO-XR 'j&5sjl:T[k[ M\Fl9nVD)+$bhApZ}$'+G6[Ϸipq |l &]<*U$8_SN$1h% OGJDTֱ=I Q_1, F+'>GfH)*"bҗ}\tN hNRnZB:.U.`HQPTH,)|:jSHj@c}2W@G+ :WR޽p],,gO0q(ua^z}Xqu&tpSd*B ^5 O:dF GYIJrUc4U)e*5ש6|tŭM햢r6CY$"Zf.pau\>JY,#*H-9NhaM,։O0Jze;vut: ֢ڍDɓ3yi*rvz%*EMv!-G/(a%* RQ9L:iB3el0!tGE-Lkj{dkNH&!b|5#,w.s\F8+SKRKI1Ӈ9&GKF%|J2Д%}X %gvYBR8KmfF]XjfqjeXE x!Hg.!GGDLZ@.tS% RR ".莒='OD4s]Zu)R-sB5}'5I\QQFOԣJQDolb8I!nNQF .y{ m}fLe%t = :I2'OJ+JS:ZH [%l,EMG(HΔz,(@a2bXp 5*8@1.&bh3\rM˜KN$ٞ-E{e ysc.i4PS(N}{bz4KT.h\3& I\V@I;>~!JlJQ- |a")64Q*gA2˙.`OIBv/R^dt=b)j//Q-̵sIg5;lm6W6Sv9h"ٸ`5Cߗ$0iBbX~↸Q [05}%+i'钲TK g`T+]&qfZ&JnD'tJ+( c͜BJ\ni48S%(2r=`W1hC$$DEqȡ~"¾#Ѳ~_hԵQGADDABXj:ТS{$bA쏧AoQj?ʣ~jhT}CUh? >GTh? >GTSIzz٨Cjvxs&zU2Z4(-RA 9`*""Gݨ*Gݨ*uHЂBҕh 2+PiZRA*%*mAJGݨ*Gݨ*ґ9dM$(RrKWE!)4&m53JzԠ7x"" ~}ڏ*~}ڏa^:~+ZhZ &L@x=zPULHHLmDj~}ڏ*~}ڏV"->ؘldakۜ*3ѥirAEGI3)9L ɢ7Wƿ?۹)ӗ I`g "JJ5]Y>] lpi.>C\xryroh.cb,Ap#|$_ZtjS{ghCrS)(SzٲI( Pݱ JudTgi*R4` Թ2))3=oIXHkbnRrnN96N ej%ZU&`{@P1EA37sMH _I"r59Lą}ȭU[,s1wH%3JeOX@ O_"Ԕ%+D(( !Y~;OX*X ,A+aODls2Hٝ+yaPJhRu&;'f'' kJ1;0ǑW1$*n-W1S&I>j-^ n\S ZSuRP){TPݱr鹤ig )dHK\JJRX>II$Ċ /_>@g1- "xT:Z679q;rp9N͠loKHUNW\<"QԩA8MWZ3 u% 8 {1VO>Efi'$M=־9 1h.r&%FP ޠP}#'i::ً&*bC%ʽt|S2z3!IL$┐,""֍(SNd+~9Pb 2\>?c{<ĉV/sց8 .{L$ .OG+eu0'j!$YCP襐 ,'AԱ=(N\*R! Ù%3Tu) , iPfH˞䂔arvg?uS7)\s,5f2/LTr::zS1(aiJQVM} ޏ D72e38J*U cÍ[L湞 *TTt>Hܦl \ʜp֡N-r G~Zk*tдސF)35zU93P6Dą Ia j|GEO]|>M9 a1)X3r +EQ :y˖T0hQKxr?[-4 Z鉻4Z׊b|.jT-@y͢S"Z+lbs__[ҕMueʘ'کSBe.{!n#UJfU.\ٳl*DMXbAؘ:njO6T4 RJ~\I&$PT?6:bZHEeho9qrp&.kMs*4&iU!\f?8MWZ$N%!EɩV)H{Vk_r]jQ)jDsQ1*!IYA[(p{s~9ziZ٧QBR X$U|4s8?A)3%M>1k@P DEP륲V6}TLj|}WDqQ|cK!\Wt *IȸɲtjZ@ vCX8\0'YecܓVU8,=(\4J԰HtK7ud֪\Ab]N;:A%"2rF\97RA s`#VS4o9S&8L{։ ҥD+̝%P\8*a/ЖoFkStZjtLbRAEJN-H%:s82,GadPJR$Ŷ#las؎,b #9BL )gbšjҧM Ae'z'ifRG$MU=36ytN)NBbjR f  RiդNӬ,q.N+eBK]6VSplJ\lmO5x@P*y>gc~Bҫ4g\*LbRPg+)upYQl 3`JE?C_1lZkrTK^#{^=:9!k \Ai+ t9ZP%D8z]ٙX9N ![KNT˟0JB@VvE#jdBց܀"bu$ԩiw#K>J䥰K)"-_LkQՍoM7u BrI4^UR%.P& RA-.V>ɋKtVڗ13PVGq֙J RS,k%.Z%3`HJ,dR1oz?A`&s9o+K-EX@P]#qf .Ze&ن$BwҔrׇx9H(ԢY\RYJ6\ "z֖=N\* "TɫH,T)+ }4vrJ;R` 4KA&%(!C[W<]Kr;%t6hr:&Ĵ.FntCC!fItw൮8TIFpO%BIgf?8O+\&|(;>ZnsV4-2־ M RVi$pA YB6Y53z:D2I3PJP)Z$sSйs dRA ZT 0DZM `|En9č c@յQGADDAC_n5?CK*>0z uQjz YL}C-O0DDAiNbVzH-ha!135+ j1%%E(+Gj}?K"" Wi)RS fJ BDqDPeΖҦS2H%f"S>_GEfHTZpP#3x`*uR*^XLs J$3CE/>_SDԈK `&L-,fXMrk4=+?CBRrԥ)g*tBdu:W`)3gb5SḍCP ss^}!%SdɔC\Zf/խ)I**tO-TJx?W7_*~0@3J:EBܣ\[HVrg/ 9| zt)ZрÑ|Am`S e9DGQAeAR61ѧH R*Q0xI_kL:Y$u(J ,꘬šJڕ ;} 5 ,ITAĢ,!/rO6HFTrxKN{kt1>J5)~*a/)3ZU|;?ʇ4e:$Ώ* JTh(*bBJI*(Դ S#J~hyґ-ncrfxcr.r,cze7oCmH#k@U: uXhp5\FgD XSaͶ.m_Bk˜Be R]R($pDS7QBs牳T)SK) ,zWZ:E^#ui) 5RU]GONf /ي|t&4b7^D[-E.Ze!2(HvԖBP%!N-)褬LF b|UϚ)6rPo &ܣH3ҟ.GSͲڤ=WdbT-}D\f#HZhQ&vQ%ș}2bTWczBY$8SKL>4b,S '%%D)w׫ %x{p;M$1f ajD0(EUoSwiDt+"~8u=t zJ[=Y9LF%}KEYCq.eʗ2 aa&?u2~FI˶MkkZ.w,`Yc0"j&G[SvB㟚3gtZL2tYѡJ=%ץJQD JIfvU'5%ԮvfRura@[?Hg'ƣORx2 CG)\PIU &e>ݣ9iE|J\ [<-)3ZU1? ~!GiuEh&|nHYl%!RS^S $W9LU4DneȾ%6=84]K*Yз V4ڐFF9 ~*T P@Kj3~&B,( ݇6FB֫GM2zVkK).Bn"d,!s_R u; gu T֡:0f4UHQQ8*Eìp Ɨ`*|t*4mKm'-E.Ze!2(Hv5BPHwSfFBz9Eh\թKlH,MG(SzSCe}w!jU4li<CzILRǎK#HSeRVGx.#V\Y{1zamnjPU F?.T'?U:\S)& 9K4fϓy(2Zf-I5RT*6 w4j2H*-:b~.g2;\_v6=A+kenH,- ކ>ȚHUT8 S2zg'ghMѦ\:tԜ>oWI 7Q,H>izɒR7,iѺYxSB%\*XU1HE)7E>IZ^oV3fOPKlg,2栯w"-XЊ/+1s)l"r1ֵQGADDAC_n5?CK*>>kƧeGA3 lI\Œ֦-].K01?ԑ$3u ZD 4(Pv ^ꆎwZRV !*M5 A!LXqhq=--"R:L.bDrR %H4MI""Mz D*eHZQ J,l@/&dJS*Jf) ]?0} !ĹTJdNf)RYTΒ.PV:PuQ41sh"" %Kf"]IEjRLh#SDMהLLʐ&(aI2H6` B9pVn&jtU1)(\6bH)& 'x0 Z1 OSYBEhS`(,+/g~)] JXb-$kP |E3&I;l/ezٌG h)D" vF9qktQLʍ q,ΞS9mf}2fuWmoFSK0/s ZJ6e/jAg':ffS&J.H^BJA6$J7Q$:7T\這lL jTexbu0"\ӭHD`؅$:Ml@1촲ݐGw' ӛnau|n1&;b@e̖ir6Nrl{ӯkHep$jSC_UM j|`|s~5ZI: jf+Yf'Q}bM ]%.sQ&J|s) JfJQ7PJUZ餁cfGY'U&Jbb_ W+- $3zR%-ITɪJUD Q},oog?Փb7JHEj1ɭLf{l.g<$7s8~]~2fxţKZ2X񖹨L,NZTN Q{2?Y9l4˲)jMxH:h)) %)5`,i]#,J.XvB'-(P&lyqCA]91UŎ'<9Zј"SRzzcp%]Lfi'( cnFRɋii,VF B\v>]t痤fT) 5*jgjTTYEL;z#;kba}au#ke`eÀcly,K9m4ݴv#'sH="M3@2k=UY?GCFi p j)d6 X(|Ӓ#s&~0p 7PO%|(fW7ٸx).N\r&%%SUsu)7;: LϗvP2n؈ %L!J)6;]#<1b $ugtcIӀ `tŜe a}i=IS]ybDON+Z!36JB,`rzErЍ>RƑ+bH(T \X _(U8r/m(|VLeGph)TJrm0/|TQ蟕ċ \,Ξ>um5-nmŽFRMq)6e>7U"Z',;H^f}*J։!"Brd)2nrIGu(RLDS))da@N`Dϙ-3蟧K,)*I`%#zI!lG%lHw' lzS)L-.F$qYr笖f26n$_Oc Ml`ilwp'Mx%TZkM!|B?j\`=ҿC:>`2Th,p xY3Ih ƭFRf"i"\*A7 fo~Zz/Gˑ4d)eK_꽡D=g uI.Q"\ P Ԓy"/GK~8-OBŕ2jRSAVMFY2_\4bzYC Y^־Y tX(BE.jT&ZU%9U!/Fz%1Zf(cHS1ru;am#A]n/qbڙþ< $з>:?UX[xz?V%Z9b {uF@$Bڙ ϝ[W"j婱Tgb#P tr śTL1damLj-5sتbyz#;Z_r06ÖuitFblm%I?߭vGgBґpϛ9R#JW6hڴ;9"QÚP5CS6BIjĥ3e աH`9p`A(,lx^$W†ᢾvBjuQ.n~2ʘszϗPIPP71JjKP6n~*RpH6;S:DDe:l.I`Z)<~MA+ak@ ss'[ze_:;b1wH˖DThJ*TLJ_ $lN.&sfKH1:9e*sV't(&MG(Q. 0\g89f#4/ q cKv 裮GVc4̘U92MXIbQ)%e ݊$#UtV$.LhJIDa.M˓I)TS%,(*rBݚ1ZMGFn.tiP2Z8Eb#3$rn[Ët{i7[N844뽱gYoUMlJ , j@'*lh*,54(B4jVJBϔeh(&. 2'uzN\ 05zevr'륡 l L-cr,Q}r)_p4l_Wc׵QGADDAB_j:ҠSWfrcK8O!ADDtgtgiQD&Hӡ*$"jZP7TM}0J+% IMXXWH 0DDAnڟy/nڟy/igIDxՉM%$ 6!%/**TBtŠ(IJ%ŌDK8K8R4~Ҋĉ6QH3T[DDAGmOp7GmOq9$\M33S]l *#5ANNT@e\`=DDAGmOp7GmOq VĥbdB \%E*&;ax"-NN6tgZ Di.tȖKgvab ?I̧3:ųH3П5SD׭ Z1%`)jI6I%c8=lW℺ڷߊ7ks/3p}N!Y>CNrV*HZiHcV,":LRd:4i) c.NjDq(;9ɎzO9BAH!wkPL^ÒNVY3Q>Z&. ȇ9'e=Tۭs%Ґ%U%r $l%hX KߊNT3V;r쯹lI;!{(uMTՒvSaz4IJJ:vF2MЦX*@-;09}#B~xeG*Sק|0My *:;J5rVJPjR2%JBL! QfQQ&R^ǦKOpʏuB΀m_ yWHX ,&6^k[t+JeIs IF$qY/0g <I[RQCl2($HVQ!!x J$׷KNq~cU1frF0Cz ~NlNuA9I(WXS`vH7cxVL=VP\)\(3HkF)zlVbrP3?,,Xp@ 5P.)LN%Kz:`|R4sb2jU8&դN,VF BIE {x:id|Z\y;I,Դ+ N*WlUs= 'oFү BuLRRk4ei) Ϊq͐\}S,ejU}rnplA_84i$ ?}KZu떃0TE ףHIF+WQʒܢQ֦B:rgH:d+ F35:يPLDĢv\OGΩ5Ț),vRT. #";ȵt%Nb1[ eMDh蘐{xCzz[T_:BT&FJjЪDjbSI+`n #&ܠUբ<%uS8w ]m6Pꊙ3N`4#ѥ)\dl$!=v:PGX'f>g?0! 1Ri)="eWU(}/O%*2GF8#_h}W+ġS@alD6Lֵav6? !7$2q"d4$ *^ U9>A ,caB5S£QXUn]/=)39LY_Ҕ:K|v7zIwC-3LZe 9ZHVi-DEP륱[2Qg?^ZC[loP^׏kVs/lq <_-9Cʓ+LJ*]ËCu!Rg'ըԎ2$q_ZLтciWGh$ -s&$,'"\Bi” ْNRu5Rؚ-E,2j5#2rtZ݅Lw688Wh}%/e!=Zp8-h tV:Bx$H!OzZ Xi5DG9@)&YUo(pB ϛ!~G1[&j1Ҵa#Q Lĥi.Gqg?<=IVPr1_HʕTr̠\"jL@{Rj@.BT$7ܠ Rȷu_S˴mrрטvWsdqp ;V_G(2ٓAd%V;5@<;9KRe ɖ8QQ Ts&̧(nMH;nf 2KlhnLtX:\2vVݮug[.vV8J_M˟8iNKhIgb1;rөWFSwOPR5]Ow|cj4̩Jsb) ^6ttw^j蒅\!gT-ޒA6 DESBErc6W/+1еQGADDAC_n5?CK*>0D IG)RS0%#=h?>GlAJDZѨa -+T<1/KRt稔!JLɝd^a@ )`;az4ut9F;7%L &D "oY! T,@IMI_ҵ]p-RJZ\!FFQ7_UScsQafnwƌD6OP.\HR.iRlD´h?>Glh?>GlD:3%L"RFM]k BRHܠOH<`J˕/PPS5 AwQJ?`AwQJ?`%2De)+!K5(D^ Cth?>Glh?>GlDatl1g6N+1阖-;ADn~N\+Y jgHRJ&J-%%/Eȇ J% yؿi6{p/OOk1[[1 xCORI_8>Zz^Cu6YѳV4YP)jRAȸ;&t*jj J1M`#RJsJ`3Y"K,gNRT@-U%FHJ%2>JIQ*jP@a&Ag< fl/%yHZBC>+ L:mT/ZA O_>ҕ (!ВC$1% ?GG_OŲĞoہG?ua@pEu{jftd)$rZM he%NdHh<0%IY2ScY(%I] 쭘~xFQ˛0,˙MOBL){TGl^&ANQf?M1HDO¤$T7Ip@ I{i?gR:ޥJTN>IU->Yz!R4|=Tg2֤dROTHL;N:}ZfMK H*3+P`,ꕭ%NH*ȔJT*NJPB`݋9#F"I2"R% 2e$s`+*Dz}%~ A| P񒄥qbRH$aT{u/q{eZ'Ķ[1U@*iC*ftd%šp62%JS:?VTnَAf#h*}\nَǗ|K5(R%L6T)jr܈N.3trAtTM%I"I{i?gZZ^tjTȗ:BORfKA؋M [[,& ַ;E!ּd-$He/@KGi{^_` Ti:5}ru *PIH,:m>t0 $fw>]+aziuFOG˕rO YZ+5TJh˖)' gk&\GJ1s20*"mhui.K:h.bVR̜$KHR["Ս({qQ3zlc) u#/'Y čĎ.iĎ;<8+-xb!h?%mʲo@)S?MDRSu,FA7h ҟZbS218 sҐW3H rRcHiZL=J'-2S) f.\6"*jNd5\ JCO1em8fI.kr0T[az畉z=Xᔩ)%M{e#dRTBʈAq+)>I<]tM$#S)rW57oϒ)XXut#ĉʝ%ԡ3ϥHNT ğIF/SI :Zic%ژ5EeTTǽi%ct*BǜpǘQAnDDS{J=M!Zebj]F`ɤGP(Sv۝s[ j~ǥDwHTش%>饍4NVM*&dWb@!$`Crծ̝,NB 9HZ}yVzRHZW#M6J%_ZKL=}ch&sL&Z,$F&ZHB$h}&`)\JLY\“@"ʦcoz?B#L8{@%6(}qU|m6$`uBA,xlZsXjYH[U)6ܸ,BҾlYF11'n̖LS*|3RQS HSn2ZAfKXK:T is>Ú_ ,˔:J 3e"lrOZKfǶ99' !֝$ zZ'#ɗ.+v%z7̙j'GIF/ZҔk5s Att8 %FNtnZ.YT Ԅ *r]Z]>*ˑ>`bWX)kZIRw$Ǩ`/+1sh[+nѵQGADDAC_n5?CK*>>kƧeGA5#F&J:S"H]E*YRR$h&oW#R( RlPA kĤj1R3DT)!**JF" LӉ+"be rKvJ BCQI,)9er1lΉ˜=Ja$ a~gaf2RPMRsDFPlIuRJk&a LRZbT Tb%$@A1dGF3B H*.N;m'KԨ]t $Qp7~ctJ$KLJ2fYZk(%ٶx"" dH2ZH̒*HARjx6rUMH*֖@B5u$-#*`LLFJ%IAR,XJS*УT¾ 8"" t^BLl51pv!X{W7N<`NT¹ P*M47%Zԯt1:KFBZ}ce`>I`%zDNyӿZ%[=ݰF?۹)ӗ 萍>nb1R"T, XRԓe IKlTϢr?hR.я MЧΒVBJ&K֤Ҥ JE% I9* ӈG(^cNBsĒsN3=UyPɓ2b:bS|6l#g4S+JXRM2#"%k:6bN J1R I) c~Ys͝L!SH$Z<=rI ZB\9.hӦg).R.FJj¥LDuXB6i~;OH"F@12iI @"ƄK@'T0!I~;O1+`;4l.<WW5dYrN Z40TSlc}=ªgGdnqa\,ΞT%T$CY9+ia%?q:?J5r2$̘7)BT@ZɺϥJI~ <-W'FjQ˙5&K@r%ϖ3!d-G(i3tjCNMR6S*I ر>eklN&lyz-s~ʻ茮fvSKIH#8F퍭fGro#840)M ],i KVCWFirՆ,w~㈟HtJ>OGB PSBŢA/t,yū.dh|"ސIhчIj$e螮hwXSnRhӥZS;fI% 񔅩&l7%%JU4D_K~$O"dM'Z{F;e}#[f R,e0ӔHF姬tge5Á#:#Vإc.q9W}Y N,7Y@niU ;|ժ%A5C\v73WEFN6DϚL=zS12R BP2w4tOG􆴕<d 5,/*dP(DT˓J]"ehV $10)]'tzG:媎aT2RXp<`Np!8bP!HH[)%nMS&13@hSA*2VUcMslnt9e,(PUvddfYMeKL,(:[JӒJ 'i5zyHQInCu>M.HIL(HHRu*ZE)ԝnQ"2e#jTghsz9_%;Y x삎J<@NSF|kK'jtL,nv5`2lnxIB?*%],ΐZ1bp! #P uIlTKAN~$!ӕhEuQrMs(R.@1XjjYvY;_,ɗӃzic"Y6H:6{k%EME,H2ֹxl'W}(JJҵavKyNY~+|Gi'IiO0fT0W!ۓSzJbTRXI!RTҧ4z ]Z zJȚ:ZDů k_fj/Uʛ*\I nE@ UЪWR6W-qV5%|/st\0[4a(C-5svӕ2W7my=#&]25%!DJ'KU3$ +<,`rII/MJJ5I!IYA JHRKGMRF*M UsUe'0h lah:@fSᑻd"et E!{f_*H~-:?J^2(RS2d$9Sf$kDZzy~ǧZ6|%EQM$J.lHr%%R!u4X%S>nSY&d4-*Aܤ-}&ɢ׾De{%ѸE2~٥nLAݸe{~) Ʊѱ' uNi9ߞӬ@ӕ5`s=ޔZz>b[<% ZAPl"VzSK9so!3:MVj1 ZJTxj %iчHjSke=.V@\ekYR*U^2tSN>7TV̜ $EJoĉ%y_G1n~$Ogz1ŰrHed!{mN[N^W-ΌKKZ%v[8 ċV&tJ/{,v[rʸeڢX#7 Rv73Go:CY45cs55SѩNLJ&Zr\LR/2#X$Ktf hf%PM~]SO"*lJ}**Z 5Ղ -0 }U7LdMhL,ԚM.׏:h&iD8+t:KO=sKbf 'BT`x4tK!..;sßA$N,{N`Vz:e$XFsX=MA I%nZ90W(KBbݒSs=*W[YW7cD'tJiY6j D>9²jz:j) hSi;@'tNGgAŦ1E1҃rhGUҝ++iV+LeiA$T"+ealٲ.uzH:&&{4k`9d3}M^珥VeK37R&&j摲Te(E7 cFE|F1ҵQGADDABZZ5JB< N쒛/鏨?rg ])5SD?Բ ?rg ]U;n^TϘRKn С Q1rC 6 RBVǑsDDA?rg ]U;nz-TK1)@I(  d7Nj4JJ\ R \g"ޫC&w?uZ3.sY@RP)KYd9%'I0R~WQExSAWh~C&w?3ыʖ,*)PI _i3"t2HզZJ4!D$ *?rg ]U;nZlIk kRHX"#E_Pc c 粫9iK0%p _!3R4r`yi:d_gDn~ХN\'D2&Lꖉr:9aJcDpTR ==Ɍo^pr^G]M+nsH%,)I|ȄWEKӒD(>x' -2P"Zd1RBJ1٧d1islyxVUņg;-~* }#+eKOVdKbcH$$0g,:M%S#! $JIJA<8N?X8oG I&ff*QUDII8V,C jtOȚ)R In"ԯt,k#:xL'M)sD;I--)֡ڥ}|V$\L[1pOğ#r%5L*Lf*b$ةIpR?]KݗPnNVOl'..x9nI\sAig :$쀧E%V!,ՠL#ѴF >),5Kejʘ JD *ZHk#2ΟfMZ,T[a->QY2PR OZZO%#xriwg_I*b'KDDąCB?X8 SU-뾾'e'U!4IաGrDU3%nR ).%@Hx]7KvޭpQ3iw捅ǓC';soZѠHhu썘n\yMv^!*GX0ܸ6G)quJ~U)$!ZT%'u& ~:J%-EVeIBL nBXnZ'M}*RL2[S{$úCCB982Q] @ 0 ă|; K+/rq᝺gx:'Nbp vQK3:%2TPK8EIr(AH=Ikɡs`DcZgT̘ZR%o E葠RzR-4$(wq6`BV3dY+6ZVTjr#Z4]2dj&b7f+)quK~8>d9XY+Cs wC:_`'_5GD a-Z zzDʒ2uR*[3{DU&\ƭ Sb|pޒjN%P>IMd,Aj>\J}a%3P j&ҝ&9RiH_ReBTU;͡jR9? v`i0㹵k*;靖ӹG*qZ]2FQTfYR>pv0M`6gLP\}StBjL.!.wqu4Z6Ezi$)WT(,]hzV%>JfHrf) \R~.gG: ([&p ZTم`!:jdKT~o9OjJO PAMX !j? ~!G /IVbS2aeiаҐTeuAH I,1UAЇ;.9[]]dt;F0,TRWRriiBǎ,TĠ8Ҕdu1>H؍:NXXt *"ى{FxzW&LRMF dLYjke*ZRIi3B'J슺3G =>t׫If5ć z:bĥT:T `^'zYԍ>6P[Kq L%h.{ ki%Ҡ=)O> a3iR=dJAӊ$%[Bҥ"d7!*I){Rt7ܠhz1`yD1:SHi<q{qS'04)'Д_Z3 H6|ZҐB 9Gzej'#D=T"rVH̷ܤYH1RйR{9Qr~ZFju+sp7_v ].[ywK Hq+]7#Q4iΜiԿv,LJ G 4 FJ E*Jg߉sB"0ZLeʕĢyT1fRV%ƒ9csO='Z@*`T.f!jH*ʂWwnDж'V݇1#e~"¾#ӵQGADDAC_n5?CK*>0RjbuGel1NR".ZILĨIv=ʧh.T\‰, .#{^!/n t_r7?DDAӦlDҽVLťe4& $ׅƮL3J',HA b(}_A/n #>DM񼒠X2۞m}!&azjdJe-!$"qM u:/K:ܥ OIhԵJ.TRV)2%e֣wcN2uI]bJ$kITJq :/K:ܥ dB DAQb߷rt_r7?u:/K-.D14_kp\ENNTK27w+OG_º4fnΙɝ%Q6ZyT$ E5@ǫg&P n8@LJO2MIDMhd_^KHӗ-9˱ /D'T)_xźTMO^bP"ĥ sW^zHQYk% ~RU֦8;Ҭ)rֳLGQ3SMVze!D3'LZ X}·.x`H:b<ζt}O=JjL! S3`RG'DÊz%C.5c[ți2B&bYA>b;?ʇt: R>L>T%HXB`VM)mR+RHRf\ j67HBmrO+=-9R%9eOMF-$6˷$/CzDj;{XlrB4RA4!IkT/ &ܣI8y.Beu3~Zw}ta620|Ef1H7.:TkQԋ1)=ut.\ήle\;8Du4Z蘇cvcE%@%2J%jQEmwvhNFrZRJxRTA BtX'hN4҂D(T9()}1?Dgcl\/rv;G# [:\pÈ-:R ͔MkXց`*t;NS8L2TٝՌ; >gZډtxI$;365[_N[9&_G˗tU ]f))aZ) W%HA:Įd"OT[0ϒLGF"M3<l̉f7b.deKI&*a"Ս({qQ3L[L$-Co?mz n^|H+m͍.mu|l49M ɺg@N3;I9 skb.9ö@Y(--+퇐l>5jJ#R@ IZFgnOX'ELX58kX<}V$j5SGGqJB85Fgkg:h4u)TʤYtR䲈hbR:u4cZ nzEd̖VeDq TN'@!U)JI S֭JRFRq=}% Y( -E*ZdDHHV\BeHB$Q):mT$ I&tՕ)8"X)A"I$&)DÊeͥdK{nct>6Ìbp+OM(˘aIgtD2Z҃]wb nѡZK%$͒5!gr@,zdӭ*J$) Ib\Z5>>gj$ ^D8sJ$I&I+o9ƴ|XzZ7H  WlBuZjℕ*)8"،}MJ!کKUIJ (pmtlhs*KLH6&P&iyiBOJ0*@3elt\&N "tɨ!9 噓&)kVT$v"-" cFaHԵQGADDAC_n5?CK*>>kƧeGAǁN2- 3<&TT!TA!KIIe1 ckƔ5RȜ1IXWH3ݶ""Iì Be-HXY+,YxKE*\Ӑ& +DR*t:薔)ÿDn~N\+Ihhy&| !%Pk.\rsM[ Pmaxx\N|I+DidξvkDMF~UϘ %) l;4+ *AeKP)ұAhCWѳ3I9RVTrDuZOHu:rMF X QnNKel-ND/xm-%M^JI*{mǜF.ɕL^4Jե_K,1 $Sĕ%!*A0as>t c6A6hDGV:DDBrwӣi[ O4uBfrZ8-)惬8ˇ H*lz⌮ZRe))}nhi&- \R~!ZՉBZAP2 EvHʔBEȅzCUN&2`O >;]} ;DXK)!@etWdTMu, &Y?TiKlsXT&͞;@xIB?*K#O3_9m*LBTT"R@%>RV~$!ӕ|V "pO5! MGh>{dkrr3O&\,{NvJivQ#\/rQ4HpW<-3S6g_Yq;%[9<1}uf| |9z6vUj"PZ){%,Ru:6TR ,!D2Ҡ{qSWњfVz WҪuQN龐i2zI^\RTh`f_C+zz8K^l?tA\d-9s_Y3"Qa_I+TfeP8_$JHӦeB[B&KsrR] Kx]7Ktiit 2f.k|8$!\PGMRF9e1v Zއ z<"-!.I"6q=4jiJִBeJ[-jKZI&sFLtr.7Z1=Q41d$بuT٠{DP*UR4D_IЖ~$Oź_g?TsRY'u$.,3Ed!I8p"F",yL21fq_+iv[a ee|_/W[5kZh)KpOas;=fhԩ@3M-;jNz%(JBjHX-Y@JTe)Nj]#9f%Vu*X4r.gH.a'-75ziHZfևQ]!&va͛2 `)fs s揮tNjZ2&a7i gC j2Ȧ`XYitTJJX&{FCb %RҠUdYG]d!WĹ U(PzJ]S+͙&`eɘ(rR Ib!FL<#[0U>z2PQ(NT j5$SLX[}u:Xl簆 53x7. 'W0H*Rd(7e&RrD8{vƖJgiR2%IZTR#r@wJO<'LY`3ulNO`j蔁1r檄jdMVp)Q TMv2V|24`H$RAtX%ht{_$`FV!w9j 9Nkr󜁁r*k 5p6 Y{ctp!acNm~k%=]^(ҩJ-KgS״/UN) p;^.Y%*VOJ張#Q$k?(zFOM6lIJ- $MVb87zkYD5sQњysBR'"ܡ.&Q NZeIIRL5@2$bD#z+_p4l_WcյQGADDABBZ1}ZNNJ鲶}'LO!ADD߃>fAO/GT-&)jJ԰ K!0aY֤%tR{"" |I0}2}t̎j_QLUK=Vh!&b)!W {]Ox>`d(A%dBeMBE`LZRK9#>>f@FiRfac̲j\!343DɠKN K\ %Ox>`dr~r$l3(Z53aN!X"-jڗS7$xUs#O-sfDO`yAE d'89L:I L) A Dk}C9pTrgkLD!)W>`Q3 IR Jp^<|9#ཆ=l IfvSswJ4a-wu !?/euNZ V'ƚ4ߚקTw+ry'̝t,X8M 晓Ե"ћ5d%*9! d=GtFĵҗ)cү8q;Q,朗[5},-3%1!@WDÿUKDomzO8D::hJVse,rRIsJ$ay~;OZt@QeY O4uMs˥q 0w w'ZWutvf-]hS]@b~PI*iա2&H\|e-1Bz)e ,C k \ zEE*OXT3rAN]N]6:G`CZ` >!ben7NoWs]g:toQ-lAp4z&gS [5,AphMң="&is;JgM\|ZU0͟+Y9A` %#dC&S"y *QRVlHk::OM:r Z6IRP) 7Z)$ZI*sDEPm5XRyj)w>Bog?ՓcXb9Ӝ8\.s М O[Gϛ.tVmt,k08rZ<9d"2:JʩP S;^2zi&z0JΑERu Xe$˭ OZ V; j#I6j:ϴt̨8ZtrQ@ɇ*\ɲ6d8jB˔")R8URtSMH*s VTPW0C55#ri 9O7+:t;\] 9K\f)NSM[|3YދU+S/iZφk1 <kLh[<&RK:0%@Y>W (*d&r&Z$)!1$/K:lI(rR IDz苨)YI '0;)Q"ZP]]6bdSY)bȖҞk}(y'*+HB*I))P ENT5*LD*RP*%lĢZC R GA##'Zy3/^t>XXnn.ueCI+ܧqq^ DepAҺ`;VGZ(Zߟ2GHHDu1fwH:ѧ^:ԣ[!?A ,$Ȝ2z1 XQ~I2yQ9Uh(K%) OGM!+ JW!tMRbce Mj6WR6r,떼pe in!iҰ=5дJVP r(TZKf6"TQ25҂JLT|jT'% Kt{u/_CU@s,!|ɊH]+E1G]'HLivb慵ڹZdGXWf{G:_*O( ֠=&H\K(ir 4:_ "IU !JZ-&d5$nVF6J NPc5g$ G~.t'.a`WElm ` h`7>20Hn1w:9ji*ܦ< g/ o:tVi $vQ3:HRKlHѝ"n=iiGj$w/$T0͝3ZJ0X`1 4zn*QRRI6.MRjJ$%3dIb8œ{HJ"X-Z7̹_* /i⣘403x.'BrnzܳܛVgNJwGDŽ_@̹MφI8.%3NRu*1)S^Ae eLJoM<LR.kN Nlh[޴'N n'6i脢N\.n1Z:ԅTED^=;Ytm:VT=|Li)YO`92pӟ$ 粘9%l@sfJ1e׶gy'+@L%hPRA@#sQO >XkG.VN|&i:Wt*hKZǔI)tJR^!Q~r0DN'%Y):b${YE٫j?*IlyOS=,d,uc3 o)+ M-Nn7,LT jpڜo@ 5NzTO+LaJ9%@3g^RdADM)9d.h!*C+WC:mBBZBX%!/'])R58䭬]A216E]JgCuJVXqPZB]*bW @L]WGGzCM.Q?NO!*.!rޅ|;ěޏPZ}TF `Yf>wciqשD++kd/x9}%@Luf%b݇š\2Bf#+ 3 ˻4:)z2'ZD\$rBHTݢ,ϚQ-)Z/%2$d ܰoKN&Q:}+ 1jS h/.Z455X $osU6Fhw9*rjSܦ< `A׊A4i "Ju=H`% %:|0ي2lҵD@ ,%fdA5ZJ%:HI6.zNtl%(i(3JJfJZCJR*Y'V44-+c$l_WcֵQGAm龆! M R5+[uR$(`\"">jhT}dfu>2E&d *إ]7u"" hE`I2Xol.BIOS%5 .l} /aDDچ_WYWj&})(T"i>J}<-I!e5wY /awAw_6Vs5IQl},@JYen9a:$:S*dS-BdΥ3qJf YҐw;B /awA534g$̪E&Z]W)p)w=BH&dphf^ /awAGYD-dJJb @&Y'д7ox.l}Dqk&[^guZtLBf%d7>W܏˅t:"/:L=Z((Ԑ J5@S*nKc)J*I)!`0Ac*)FfVX%M5JKikLoJT9G [Kyp!mzI+:fdMv<1]Z]`QLƌhK3Pg~hWT(JXÖɊ4 rgj&ձJRJ|a8?d.RKS<+G Na\l;6.U2U \'PZ$C$*Ltje^˟/VJrZڔ@8%)JBRRi:og?ՓaBNH40׹&Z&6ʾ cO8,t1 cpAL#9VXi:OOT K&jp ;v_n(X9DlF6uzsKERZĢ_g*PJ2LŢdj -f)3 x$I/Y3yej3B@;96z$Lz 5}\%ΨrL|t #lt2X`."ړ)2%R|Yi>mR-8B@ti:]]04ΞRЄ"J*=oYzQ-L֧EWvF M$7=>ʇ5rTj6u;7]7. .j*gW6[\A++SJ安p ='3#TQ.|pUi!3KD2Lt) RlȄW0ReZ&ȕ6\-!ݥ]3R E{lA'&c3ۜKoc}Q s.]c]}Ԗs q5 *t:5s *Pvg1VA8LBJIPp|a鏣 T}$j(hU[P2: QGu:]D 0sBIJ M4FU3Q/Vؕr„gj&+W3 S*$a)HH HH }""֍(K'㊎a4bt&ũW>FT^JZs#8sr9 f;'-Όl2Rf;۠yC ; ƝzN\,4)JK ;e蚵:T%gpv3)ը,+JJDkJK@l>uI螑;Q(k&M:FOIJTdue-]iT%ADY\سԉâTkPkMCc@X``XYanM>drbʛƧR:r$OJ"8*ZZG8Wy>c%4EKP}c]AWtI\ \1vHJ\ Ap}" G?(aI:΍2%v|XʤDP&Q@*' 0rVR>%]bJ2^-*` O4Yy"6:4Y KX~6G!#,p6ef{Q\PU==PQK&jp37V%*p7D`aCE;[.^D?daGL89 x'-TH7) .K-NʴrK"N PN;2zb.^1eΩHq: M%- [(|2sKLhZBChՕ,JBeHt;WZ5ejG|ҕ}xPt7ܡ^_;Bf(PzSG, ='b>yDi` ˃n 8)ԫeaʝiw8ʒ^l\`\A++RS2R蘀@.@ u1Aț$&j R7O:Td$&bfȓ87Z.p)a#X Z& S4$l{"7S\rrH :۟["ѱqn }kr&; 26FִX4 lNU0(.$Aټsai;PJ Ϗ4_E@ѧI>Z:/NhH%sj#Ɍ6S |2ZdI@MDɳJYhXz0K/eQZGrVDܤ(5ZfT, iBƍ/lyĀ׵QGH$LKD\ڊت7r}赧K2l9YAffRu2%12)@n%(RGKA, A)rZQd}ֆV5P*YTtސiJVJU./b%$cDD;1S5hSQ%&`BѾ*j--A ʋ1CnuXhceb>JֺRAL&y1;IDu$ 2 MYHtdLɇU2cuk^ RU, .44zz*H [1cKݟ8,ԢLjxzR #-,)E%ƬvH$LD4 +0-L %Ŕ E:WKN< }4ʕ-DYDLF%I {1=>ftKTT9RX!ѭA:j&/&ZaŁ-:T'TUՄ)5+ H4n@P;<D57λOUCp^f*`]ĢVJ`U&׆׮13.rP)22V%Ir˗x^jRWTr%3%uL1RĂG$2DDAꞞJjRqpم!zĢ~dɋy BITBE%![Rxf䆓[9[+GqL33(;PuWfM鉖H`s#0F?۹9ӗLBzr"S&NRAJR)&r?hr.$>~"p%*AD7ʓvt.DKל_<ςO'0n`tξ]N:NlՏRx%'H?HjtëJs"o$ !20hzBGLT?WRIdʞf`:d|}R䥆8e%)~xTr,朗[5sS[lu[k4K3M%sLTkbyDb~RN#T\b LꤐRrR(3t:}.BegNЭOV-\)*#jN_St|#bҿzƗ!WtNűs6h)R8Cisls^ֺ܎fوJ]U)!!CQ&'@R-OQN`CĴZUku!=bp$-e@*=JER4i-7Q9NǢ'ej1e){%:KVZ .ܢ>YZJ% *pS%A.#Ӓ^̶Nn@+-C%Ipm8+5|dAlY/8JfI)%jB% GE*)&%>*%&ZH HSju))@Z}-j@ｎ{Vn&ݮ{X`JdZ9${"Pბpv9ğ#rRj&"R.\H UZC$;O9Pu]3O.teRaH.ݜݥ؞7:#,>Üf+|?> f/֒'&tξ]NOcDmFSa6j,pHid$@utuuNt~$pKIe trԽ?VKL&`kӨ3\JMD#/Ib,r\kjt:7Gss[k4k3M%sLT q{m5yrw5rЕ(RTQ2Y;(X䤤7Kt|FBe&L7D?Ki0lm.ԝ.U"^w)e .SISr9ϛ-rf.TJIRNIb8Z.YV-=|ɲW'Jlß0s kW2^bx6lϘ9? ~!G hJ!zBЙ\*$%s)l˔ 0|䴝_F27C>l⁕IIZ>MC}}CY##O)(NiBCXil-1qklKg`l KϠ/)ȟ3+Ug&~QRRL*%S}z$k~u~:: )%'Z(H%"()2>BTBdֲI< e~C+Rtr&q:YJ_L49/kUң 'ɒn%E°MKh+]Jʀ2Ist8g esLj#<]Zu-re`eZJ8TL 1r/ t\J!W+]IR-EkJ* t7ܣ&eJQ5ef_zHPu MG(FvfNǚY* 7޴r.Tnfl8[/i2ҥ"Juaph,>hBB-kg\M !󪕦'K-LT9Xc5gr ihLZD5JZh3Av)P)Pq"X`{ AVJrpy:'5<s ޱg$HZ)oZT)SRcc}^HJW9j)~7&zzKM2} Rf.Z&Ja, I }WH(u,8d!eKA#J5Zl@OPl"(E~"¾#Ѳ~_hеQG<6_BU#H%$!JG,f1Z~W&Gț uS!t1L4ҹ)QX5% J1Fв3WIZe$ĺMJTG$=O!ADD߂I#? I?sd{K1$sɋhfA!+ RLDT\Igb%~<OQQ M$W"b̚$)AY!67Ȃ""$͑u6GE$L&H$I$jJBP)bbf ʡ0*l\6GA~ h)JD%Fb!2_DªVo3&JTU!K!BBkpM^Aw$͑gA~R/3W^2q{͛|IP5%lJ%{Q%Y$ 9L&1@YcZfK% A*OX0A pDjC9pD*vRiNSNQB  J.AP#NSv1>)דFQØXscˤ9RTN,:r|鮍8Uf;X(bnNf뒙{T%~ЀNFIʼn''ܙޓ.Xĩ'r2Gig;Kf|3ɛ,xO%$ ,41Yp9.5YKLR%DSJ$NI4f--=T֢]kO.XӿTԤ-X9Ab ]*I71DaY:ӕ37v߷rʶ^=ٚ <=D&BCxqItHiRze0.%T+HRN>T/!Z#O<@d&jfց0'p({ j%I 3JRKW֡ fwH/'&*0qqg!<͏t<:u݀ EpF"nfPU%9Fı>ItWKMQe1 k@ %%/f'O VH~mJ9%ZjSJR)J=J=~V%n(LN%S,"d(#(ZT/r' NzZlC#<7JHEj1,1Lܙ[/qqT6 ECD`IѨ-,/NJmgKҧRE#)K!4j(cW*bTj!HbF#b!ˑ1&`=j+-R(!)VtLTŀ)R҄A + XaUkUjR}/ia6q2SNr]\ӍuZ]d=XX`_cC&d"Z餒LDb(*b)D ~GaH rV&pVΖ/ƙ()*vM(N<ɘ))jBvRIyW,q8^jړN}osMN<͘iDOdti"WPPwUXd3%jJgO9PƎLIԧ)iB$OY9`C(KBAR؂xR̝&&=@6^vyea`.HKΗcޗ;*'YWͧ4OBx%wakSɟ3uLJ'Lo܀@ѩhPܪbYm!RG$E)a}RSRDDfK<W CcXig鈃gg af_M-iA+H  r(2I&z %!nHj.]WuirLzU.aEԒRj J{:iSh7KWк*ӗ3,nlvfȸO-A&BrNfʑ^h=i)v/`8⥦`)ZBvPqy=+TVHЀ7H"d6I%#š=1OD*ZTBJֳ؄$CzIRV,gAr9 =t<:u݀ GpGCqݸ8] Smv8:})zHi1 k@zyR_BRa~ꔇJ.9fVv Ja(JPRK dTL=&&^M3S.Zej4ȖeR&RViK$o""܉ihX{SHKՉe 1؈1ԙ2:ydLĤ`JJ0-ZlЧT/!>t4իQ0=b2Q,"6c2Z-r W-E*IRK{ZpE9Z>69gΗM('s1>ZWňJy6V2 V*!/O >XgI&T &! I$2q rlA%I7@:#tWlb J^S8H֙ yʷ&h yJ9$Dë1tGx"d%Cqxi$V% )k/3I&z$e2eP>HKp֪bM됔Z3֔KzI-#Dt'2uCoKR"M?LB$g ,JVRVA -:/! iS`+빤E2$*\GOJ+HR *I,*)1gG{ ^j(&%sp'أtJM<87!.XFXf;J`]/`/3Jej%KRPT& 3J%U$l"4UBRrV6ۛBZz2.239͘RrCo7pp>xFkF`0 Sw$f#F8)]@Dtl΢Vi/  k@#IZM.A=i}-,8 W:j窹 $a)HHJR6#"WIkd*z?A P;1*r:GO3Pz1O\ e 4jR,BVu$ DEf$P!+#~_hѵQGADDAC_n5?CK*>0eBtjLl#<É<Ez)\oKvP 9F!.X)RU,X1/Ŀ pFP~8"" MT,R4&P\)+TPȳ],fOer (ХEr+$%e\#3|É<Ŀ ѢButjf%=`RTTb[DMӪ|*vR)%WXU ,Kqp/q/{O8h fNBK&ZθI\ХJPB u0j5&ϜZyɮZTꐤ!)M) BG%xix"" É<Ŀ C6^4[&A[5ik-"Q ^dDijA|?۹9ӗ EϔjQ1SdJԴRD2祜 mx[3'S) )D2l8%6hNsNz%'s-+ 'T L6M! 13U9O4JPu"<{X :iK"\v^NC]?PSQ,ReVP;rwJj&Z͚bR0rI&đ$SEHZy*)cq%Z`ᨮ֞^cyĖMj,DBvJJ'a O)Z)"c- n\:؟9)FАL5aZ@ lߞga}S.<|:/-I[p ȌXg<$%' juJ Uj$b`ާe 3iP!n T%M|;G:<:}vVA *l$R9,-gb:L# ~-D;OlS;UHR\B$RS-wRR&2""8/i_Y="tR,i'=Y\4k7<]v'ZAჂ= p۞ uNdL(U  |^:L<ٲiVAJr"TE I)8"'VN4i MI/1h*9M:n t&jEBI)RT$.-u}KsS#W$2@4lN '4.mcY%s`E ,]pqfl-.tl 8|PsrL\r%SY)HPTŝ'F]Kz'jf/TC_3PDHҦVT"h\v\.%)%%o/ߧxENmo[kXӁ醳O3NM=bYAğ#ro虒ui5fr3NBe- b$+2ev L3P؅؆ ंAE{b,ao&Z4}Gȁ2zGz\精`}"B$)޷OxK;ߔuKJwFs$BIw{DWLVjej&R$0d ^Q JYjgO֨'Du3tn-,MDO4K B݅1C[sH`}NBteIq).rXgkQUiLI| 2mbGMRD"dժdɩZ֢TLEFKLIOS4TZZv%4n.-i#; kgWsMZuHk>\ Q#p=!ZSi.didS U- $_ z&P!rD}t̖&Z/ q KF3U-(X"XRr{bTڢ%()wQu(ܒc"/i⣘gO$HsP4YpIb8fzh Fg ^p~|/tk3ET(T\!x}0 J1 pb{ I#DNGNt_D!Խ$e1H+{ػM>d+g֪RJT$8qh_9jBރK k+OG 9slgδѲ(*d @Kܹ4Zej䤰Zlk'd B;Ӫjp9iR36y#JZyK-͘ =) Ciq u?<?vTru-'A6!t˘״9X9ҍnfzĆW"P>#: EաLz@_JRZy"ғsNgf f 2JYI ,Dq0bNXBM㐴hpʷ-_Q6&'s7y̏Q )Sn;눟GZ%f$5%hugQ12ҹ-2$2E\WN JYσjgnbVRObې͑I@1;S9O4 %P[1CXӗ2\8=O%:y2䤸Hg""FLM%K+JOoWJة9$r.d)k-j%JTIQ.I$$ÚE)ĒP>۔acL]ָlonᨮ՟J&شY}535\ l̢pb tЊLVtaLA_gx*fzTRbH8Z1I6(<ǤEӌcl1`˘%N dhԚ9qߞl9uNX;X,bI+r(qJoBjNX˄Z;&3zC5$"t2J\; 1̭6R"liT6T7:-ȩ/#G]\a3'(X!jO|[:jR D҉hdB])srKnI1裐E|F1nbY cҵQGADDAC_n5?CK*>LDRp,;I>skƧeGA_j4-rr7N^rg$*@K! e\JiKi.Usuu%I@Q=cTKDD\RR&&\ctA։d;v֋r?hr.3Zis7S*}55I$TJ4$,?۹)ӗ wEOMD$dZLkwiSu,O$wp<|\qcLjܓ0 ԃ׍Tζطgh[RitNudF`jԲ`OJ_'Y,N1pjHۈ`Ez b4Sdj‘M$B^͜R\5y:`RU ,ئTD$8h!eZ} i93:_oi3f\i*|bZ*$s$OErԯJTBC(X_S5JvTn%:PVP;rwx5/qZ 'P\'8cstX)c7Ŧ.6q $j4LJTM,qq-iN"[W5a!@;l!2=)d!+<$P2eaj eϔKDPNR'axNiS2_sgAT,r$ߊULؼ ٮ{\I|+= wVwDk5Ҥr˚RMD1w *. 0}\'{ɡi"SeIijf3$BDnIH*6,NVPiHXWYL"\Ն.Gz8uZ}vvH|*l&e)J~)dD_a+"~1'Śof?ՓcBy~s|HBn^w⯺5..ñ@# K[.dID% %XY9$]tF6T̖ڹĢ`yRR8T Mj :Zu7cE3ҵ)NNPE˔KGaBRܘi鐮ORB5LQ%LԦ6)륅Jrsu?: $ K#k k@[?CFLQXW<@Iݘw&tP.T&^ LYS9( B).3KZ )RMRK{A4yJs{2TNHr1oJOF_.蝩bR^> M ]6h9g\49:IM3is!ŝ-hU?ʋZiJ3U\ɫri$A R,̈~$!ӕ# :ε`g ojv+QM!q:h :7csO?p܃qc>|&'nLr,ku)"xLjj[߄ς$t6Өi4ê r3W޵3XuX Ih5-J^O KSJԑwtд5)NTH uREMO;j"c=UƖysx-92`kDbZ*tB(FX)d2$@ahZTlHqb"{u/7NC[LIS(FΔu`ˆ _({ lւI*j'tcgZlyHVIM#-i6\|XDDT*Z&-. .4eˑ-)VHRJARnf^}S1 T JP )J7t:5}ZRu}LE2R ;_O8u2f LA1 }6IZn~|c&)mÆCs'=>|@:f`%ǃ@Dl(P5I */KBimB=д0N'U^L%rJD $%f͗Q**d$TRŔl &uWLĨ"\Ŋnw;V_[k$'̙-a= YØ"/B_gG1n{qQhVV< ?/w⯪O#],b167vS;Y9gJe-A(@܋)ђLd&e3RX[dդ I <5}U5#!TK,'"H'صreLFI֕ iHYRtNz;G5A |3xЗKۇh٦'ɱ'7]F ]Y.h gsWɚĬJRBVIݭx fKE'O=j&ej%2VlNB@AJ.F3T6 {zD2%ku,v!=n|~jkRcեN7#͘Ӛ$ upMȂ`.4؏ZZ$if̔iMg 'O1rdݎ@'/~BuS5*JiTXWR 0Puh1#=^PII;'sMoDkf ۟f1{MjW$27y ·GD"FF_a`V,ؙ̫X"Zu ը+Ug%9auJ8j+ulZ9]Hhz8LB/NqS޵Q5J2NY<(mQRyЏMh#tRt13Ek*3DvZ1W4e&qW[kP5ZXdRUGYNʈpF,˛Cx</ӭS$Z)rH!}dkXe) $v kK1Z剒RHe )*BI,.oz?DE&NA[-kIZ{J)[m_8G{>d{cc~ h$.TsN豼 i91Ϧ6߸\|IH2dZK R 3 ey LrT(H*ZH*=tɔH-%%*->ɖ,Jx{B:ɓd:iM2YJdl| 2SnAbCmVG'%t(]E\I8[@#[=iuNP;[ #].Bg*|Q ĸ#E'Rj#ͬ4hruj#\$N (n2YQ*DRiS\3u#/Z%.OV3Y1a jis$B_ ҧ9ЉDNȎ"/@~_h_p4ӵQGADDABV )u(Mʔ@4éC_n5?CK*>!4é}9H,$ț_W% %$je*ZT%Brp@܈"" >A7u#!4é}9H,"=Li2L!LRHWo8"" >A7u#*i.]x%.ibe k3 %D(TbA]7u#4éDtr-L *87۶+kZ H\͐rc}t- 0l^qar$ (jK 7&14)*&)}?_f! K߬A1I _Dn)ӦB]gi%e ZDHwKb\LYW-) F r:o+t$Ƴd+425Y+zH ܬ(W@MSWPgF^X>:Kxs^Fm6Quu ]b4SSdu+9mDb\ʊ{@[r@NjLɃ OϪ@JTG%IrVnitPUZfUK dNFoJɑ:^HBeJЀVTMe7E7#Mpa54 kB@$A"FLTٳJ$I%M"~G>DGD4kB,%)r- IJ8Da`ggs0\֗8I:O[480q9=+䁬HlFٙ9u{iv#::h$>\KJC0`TSZjK(:%.X9,I^=VQA ꦡ3eaIj½ʶBR᩶=V0G2#$IֹYnEXf;T.8~*G5^GQ5`Aʷ`QZ:^'tr.:g֫S! %)Q#Tڠ}&TODKHT)DrA6\O*\ķ&Rf#h2uZu RViLeDJJI 'qr)P,ԋ-8s s/?Q7JHEj1zh pokn?>{a؍6Rnd};VJ(N(#)H ͱUI$WhxM:du*&dİS5hRT-mgI@hSISP)b"\.dbvz)oKkJI bj>BAQ.ZGJ(YGp-˧'rw~K5:MDB t|ܼr-\%N\:&&DK*9 H>S>m/}=&dP=&A|TNB@JHII.g- !`H$Abh0_/cdicS\,A_K]H]6hNو-S&!$0*"W-(fb4~`&d=Y* $) ,bNT]KZ&u%CO)!1oDI!*%DR bX[or48e[cd`W$r+In h^SQ^Hkp?[dҠa2e5_(4 5M4e#S,䔦\j6 /`̽X #,Ф!i @F7G"9j6bV*R5EFUDu3EHQ jx5T閃-fdSRYhRTg b{u/WMͱio[.sX` 'P\gcg[9ĐmVO$ b-H;3>\@#m/}>gRKDդ5TY5c k榄tyJj橃r䝀xmz:BeMt̚JVI>HHBKI[p Ȍ[IIJ fidx#D QV2pF#[ыeV T }_G"\٧گS&Z{JT9IuS'jI2eʔ&ZЙhQ$)J%GrZ}aEj}R%2[125:ujꌥ?NIHYd̖TJxTIJ r9(NjE111Ym/}_gG1zX8fpkx.IYZNd}9NU+<|>j, 3UI$WhxO:dfDɟR5"R-DX=oLj5:u}HOF˖;U:Zf sʕ-aХ5sXI !‰a_ھhJOrЏx:tQ@r{Cl.e5|6weeu :7SHH]!%'7;r,ImBKiĽ2&ZCwAS޵zH4e#Q,%2D$Z~:,02cf_8F,!I @F7CsfS&LJֵ)J\Ja%3\FW[Y}dSqvRT VCNRAjMq{ r-:pY*hd=9Z.Je־&4(h͔A *5rMGW>Xl1:MYQAJQ,:,R;sy|>xpJo܉3.j(iת(`V|eJR*RJAQ0enP3eLrj?XpDDAhW,i12WLf-V!J๳<5+@)VV4>% HJY8~ӵ_w,;Q|""FO6ZTFZ4BP& ˨MaK(nrNqZL-˙5(()0B3 %ltG~9bO7yN3f TR`R gru5*ЊB:PW. }c;;Q|;Q|""fʙAERt)ITԠ.ǖ|5bObOB Ye-L`KpeO(*s L/`)Z8]%8q5K< ;s1Dn)ӦEz/tNR.>T偓)H\yW 'Y%&NX?LA2͈S:etsS:BҕǏ,IRI!IP,RAf* ::9Ti iImdw9$vV&c=5v22# ͓jSJád73Ge}73U$wC2DQitQ2z٣{WD&X0 5U|33}_кC˝Ӛ!r$,1RGTJ#"?ErLBzbLt QRC+Nv"2z )YσM2Q; OwZG ~MŧәF(KS,I6cf[fRl61 `i !QysuSTJH>qxsk"bJW5s2zr)B)- ~Q*7soˠdAӜ'uaMӓOX Ay^9?GCwD-(.z-*)Z)'b%dJm(yiLF`)H b**Bbc; .44'=rhsr8-^жy; :o%(U: E Ge}Ld%Kε<&dK n1J Per5mҫ&tM `JD9 E-U4YGB}Ԣڛcq[;2#$IR]кFT,J.\K8̞F>[#Ϭv{:xרkg Z ûzXLɺP*T\&Z]tȫT'صReLGM IHFYRczGI+L$4fR *J/nGO9r .W-rtr!SJ*r&OZwI_ RJ&e]9Gٲ/#d12sKiz 3# !G gtJhk&`R)RTv*H(%gm)>Z{{cej4:ERRRԅ!^2YI;؂q85>lp$Via<{C ~X2Aĕ:EDIReaO:;nu81huR4ZkL@I#,{^+N#L3IV%-er7|MT*b *7$MQ$F9&52du?К9*Z,{VYɶpt *Qlq9sI{ѸlxQ$)PN^$i6LRkN۱^\Yz.R>6Z՞Ţji}6vF]`JrOcT(rL5k(Q!hDvB1\)Qʉ1 \"m} KfvK\u!nwմ*g1{Z>2WN+d׾V_1<1oC(J*Q7 I';J+T1a]KM/H&FbW`JJBRK劋[|7>r4Jt|$tdɝntZ#V ™#I ʴKSU:TDGFe vB *;Q>f!\@rerI*WDL(^_hZHBͼEn9ĀյQGADDAC_n5?CK*>F~&RВlG} },9 :&! Z*d$LJHYdi!p VrRҩ@$H`I7jt0˙-sGPBӨIOX8Hqb7ZV1ҧTzRz!cJj؂""‰*ZIRJkMIpΒHq812pɖAu,$(ʮa_/RdRz6jJuTYKF{`1BHZJTAI AlcycK!E2$Zd R5@ֻ' ҉Q?T%Rjɤȅ;,,J3&a%:yɖ'*Rĥ HA=fyJt'Q*lZW=Lk _1ln Jld' FLr yHPI ȗ""Ǚ) \3RbCyv.]Ai)q8|$ԩSQ3W"druk%>*A䁰#PT:ljbcKKuAa)٭VeFZ2x͈ i'NrH߱AOG _vJl(iJ|u)dKCڵHRt~KRXz&rHK2e sd/U5G L%sXWTnחyX-!y9+>5nȉ5K*NS-&7ML$%zK4$ʞ%8i- r-=^SR:9z) %̙6P pjJТXĵ:53>Ie u22bA5MR罣O;j"74,KOw nN^M&lJKJ#9uAR-}d1%RBV$AqbA+3g;A%vWSK~Ne,v rwӣ856Nu崇jf"g^9zx:':7H-,NJ3*ek:A#++i[#ș.DTJR1Ģvfjth˜YZڔ3J /RJ].Ý_-* I,>DR&Íiوh5mك]Ns&͐P؃#=|ܣA]ބt[`3.EE9Ht~\t^lqqt5yT Hl/6V\3Q0RJ~ /m 5]#D%ri"B¥Ԥ8d."&("FNf=QR'ܨ ,fKQuELJ.^M=/M5tDpdxfuC:{to҆3'LGVJ J"/GM'Z{Yy_Y=9˩il2q `-ClD*aO800b~8WRFvU9  J<)//vaO6vjU8L0D_^E2h$˝'5 !Dh\&dHRЀ@fR }':DL}WHӥ RE!{b=*xfRe'iJ )J.TKb)\K-ptDI<3PzךXnhoGl%sIg Bib`iq ksÄ67!CjfDLWX%)!3/p^@%{DɘK!{o{I2:QBDr:RDKl6XEfZ@'q )P!I$lA ~iZHhӤJ(Gm/S:ҋ˛:T|z!_C\2NKm.ɣydi{IMri͖HMfT& :oOğ#r\TiQkz%!J Q*6JA,H?ʇއRPZmus=\aQԭX:NNP旸5p.M+ꛣ]pʐɏg:A41F&e.sm F#p\pĐw'X b³RȰI]Ϲ>rP' I+*6uf)m.UJtvLϘrЉrԲΜ;Zf*OHiN QJ"D%3%$(7@FЧItlSz6QTuA(qb?\z^5+'PDI SE Ap;aISe;*"g 2v7ot:D I#ӭSdZ)h#?[I}dSZERT%A)%}ԿPuZdt9LOVz0>xM7K/sX5tFz=U;i8:9w1Z:'Xi2F0 ˁ 7SRLf_m :WQ6Y- ҰI] hO3W:\@PHr@; ëgK4U>ZfDd˕0*\{WI[\9ЄxgWjmT[L.:~K\ 'Zf(P7?JRI;cdtGp&9`cuOE|cslBTSdjvnp|ͱ&8ݔx1tQ:F8DI*Q]Ԑa},Hj@)%E;aVAKj&t͓!aRTAJk'*O#QVH,KRS;NIU~*Уe(rtDu=EI&5sR+ҸzM|W|G/K3igJ=2t2Կ"N#n<ĉ⣘K'㊎c~>CKKmMW#&`2lD#0^{q_qTSi`%YOo%|5/JBeuҢ H8r3͟>jU8@*OA]4z*\TJUЩ$)KXJ$$]]+Sғt(i% 3ʂ@؇J) z)(\.%*Zऍ=/h},GDȖ?Bo 5:ؽwml= 0 R3 2KkZۜN$6h xmL&j)@&e nEj&NDUbZ ,rzPrT@K1{K,p!K6JX),\fRH!,A!GH􄡠 a21sg]s P%(#QΕsSV)61{:1myK D؏M/O6Xu6ݜ`^M\<ɈoG?(bRjJӔs&% @$$(KF|oD"ϮjuR $ NPJ^lFrMѺw y}aFg!sאּK$odM{'ZuX0\5,w}|3*β,Y[rnQnSe7O"R窙r˖VMӪY<`v@LQ˚ TH,\*#{3A%ѲKeLIuIk(+ 34c@IђsLj'N*O)b@$=cKS\ zÜs6?_q#t`;_KePKGiA$D%x$L5 *h -NŮ.iP!EMG(H/KV~:RrNII`X;:;ěޏQ6:G5QޏU) pβq.E#|i$vF7HnbgMjJTRԦ`$̾:A#3WQ6ZBW}t}\$DYyS6V25 ,A*-gwP 5Й#XKNO.z:TI B+C'W:2LiLB 7TO>:<}It.\S)QGxTnK\rCSU:T2JR+s2"-ڎ/_Wc6W/+1ֵQGADDAB;UBLr}Gn'_g)5SD?ԲXBkcMLvA1WWʕ1 Bԅ%3)QXwcb)*PI)CT@{;>DDA }꽢~p}꽢~pBBM$$1 `"" u^?v8>ux6ep0RJIH!:T. r!WOݲWOݲ(Nr噩KNVJGza4KDYITDDA꽢~p}꽢~pRBTkU)`K53qa,IMSd̖j$?' A|M9_KMCi"5JšR0?QdNPcyq-k>Cs!nnGWTn;˝|t_W(qx'~+2SJ;J(K&KZaRJ4zcTS5KRrֵL#"*=$%t$bH=\ = :4>ThMU))A#СfhkEf Վ Q_pFp/BH @F8#T MTƵԑ  A.DΪh`)v!CO5hڙ)i*JzĢbs*g50pR'GgU!m_!*FTb| FDZ%\HQ+H@#IڬR=U(I1Ajjm2mp.StBF24e#.iu0BK~seD!!)sk dFRhVHs!{#R%OWn3U %XBv!X؍ U: VES0:Nq[15h-K@BRJۼHC O0l$xUL+jIJв!h9BM[ b勴zYs3QQFNRCV蔇pJ!),&m&i׋Mcx}LP:2[ˉ+Tnd#Sw#e{mLdpߋ|:G:/YhXtv*(;I QL)9D/Rҹآԍ."J3tTeRNBY⩔II2ii(D̞'0u:SFO)H?4ѧԉa2ܖcֆ֋,Vefc_kҠPpAQ9:D͚k1EJRI99q]Jtj%BW.jA \xq t7ܠUy\ra:mQk^fNsW)37 erJjtZy@kaG:"ᛛ禉 !C*b7|tzmy+KT x)D%K;*CKD&&TeXI6 HrN]ZH( q:I\԰ݲBc4\1BWu6aeMP,&" ]!'G'LIwrObgGK!Fnx蕧 [:b%ʓ)蒃DJ)D`OMNVJ-"\*}'U#´(RS6JJRBkcI7RQlLn9č c@׵QGADDAC_n5?CK*>G:DޏFl O<ԲBҙJr1B;UD(vLc>5|DDA35:]J$*LZi8RIV U RZn^I 3S5oM<%IXC"2~5|}k? +4RD*VjUS BbHt P~D3=Y tzd)R]VAoRb8iwg|<i >x"" d/I5. NFdBe4:W7/>@Bd*zJA-`isY}k? +Mֳu+nN>x"" 1T<|Q"bQ)SJ-+1ek 98r)?Aӯ%2Uք!4oP) fi >x>5|DDAFnD0*d`͂#J%i%-)ZPTw.%@'xf¾g|<ENFXW܏˅%g%gZ(!n±4>4ӓE]g#:cL%))RT+JlRyyq8t̼ǀe<ӐHc3:oڲah]$OPeK OjLnς:91J|- *K)H8n؎ntҽ6U*uMJߔ8)Tj4J52zJZG J*~c IDɋX G|}0/ÐOpW֋$*C %D5Kfs21Tv_xR_S5UAR܀ 0JRMꦊK>8\E;#:'4pPƛ̱lESʮ/3@a:m]+ɤS} E%1Tg 쳤L+6LRob.bƷFM#V@I$OALc13-)E)Z-UjS=hypݿ ܫ/@tInf1QYRvE EC{\#w:^LԢ|&Re@TJ@@ÍiZDL Hw:C4kf&Er'g(}(h3>@n'hBz ?egQ2L= *GQS)&Q\śdY,ekšof?Փa>h, O<<'qmD8X{[4؝pt7G⯖t.DNR%ːDXt\ԏOiU,JdY- AIMRO;¦KrIcBR@0hb+2 =EITLBΩke¤*Il;ZG:iJ>’#Mو߁w#ĆN-jzB$-6hlq[kO2oG˘gN)t_.LDR&%)5Zl!(.frEJH#04R42LIJ3JL҅RP S(H<o0\,}xtı2fiOk1,"!^9?GCy6h(&Y=R y&)m(JiULZ)%+BR-/t p3~*]+y x= #CG~~~N^RO\,_.I!"t/M#WX@@qSғ%ԣ*l:ZM?%Nլ`OJdJ0vVţ'CD/q o B^5cCZhf YM"Tjꥥ/̓uIH.KM˴'6~L6 #eONIIM?]+)p)j)q3йZ A&g) 񒐞IPDZ$B7.Eˉm9p=/bfiN Hcڒ ΈG]4rG'0>Ǿ("iҒ>8Z"ʑ,)+IJ|4X``_[4%IZRzC1:}"gK BBZS5"Z\3}z&_SK BfMHHNRR$f#&e, L(PAM'DT)(ckcU3O%FdDRS1-%rBʔ0b`0)h *B$Ga9@Kb*IKa}ً35z*1+B@RtBP@ kB}#6lR:36T*a iiTnF9IIb,CXx=DbU*CU˫p*ǖI6kxIYVENwc؎)m|tK*Z gÞ`}B9q GY2j>!S&Q,!.*d$Ə?۹)ӗ KrKZ%*vqʩ Xcܻl-u| r?ø(l}COnmhDOH"_K"ZF 'S0SAC$v@tƝ^R iН< JR Fb;E"bүU,%2S*3oMΜWӫM$4#&Z;PL3 8#8YCڞ@[sIJKJ#nôF fVX*rMCRE3_Fzif`|+21\3$$vg{(^@.vpvN'pP@V0ZLHJ_T&LFv)+-]Xl<׈ɓ3Q5e$dե)HR&3I&TrsQe&T2$p$bUALdL+8=bc|btu)S@ܒe{YFz1Hq8\r4f]ޅtUicd f#H\јI0ai3²wDk]E|U>N\DҐRI مډҵ(֙ɘ@ /mjdRZ-7WKK.H\)tHpC=ifZgHYRU%L+`HtpO޳s7uZStJP@e=ɓ3>4E\ɒ(WܒvJ"-ڄ+"~1'Śog?Փcn^5I޶Q&uk٭}\ΉO] i_QIGj~xy.kuFU:_ $-* R_\?S:vj:%2 44re5i3fOMRErɪOJ!(I P[/W*t:=/Q#I%i@JPK S_HitjJR "L))S($!Hv,mE΂= *њJOuκ-*W ).Mѿޏmqk#2(;^BI78gT0ֻNb}TB&jΩIe ͸{Ý=31Ud2p_ox(tS-:]Z,'kTAS3H)$ ظx>[)=!3-(zY藒E=/2\̒A3W9I"DsKZ* bofgqжWd~M;^ ๱KIB"-څ4+"~8-<ĉ⣘t[=&Z' tUהL양rܑ|ہ|tMgDg):N"HIUeq kgLA]k!%I?KJ&×=х;S:|3/d  I;Tt/MQB̜RByBRJx!엪̑7Q+G}:9*JLBZ1JcQ:j3O2^iJWITXJMJEƒ>A3=0tn2?AJ:६͠}@ K JzdNk˺ $Ɂe u:ݷاU7PPe mL蘙o{JCK6^ƔWDsU䱡G5_HJOFI^L)2̛(-Z))s$U3U9H`…LQKV}tTmn6cw[+vߎ@l{޺ziPHMβjH1ԑo9^|vHə>z̽6ԐRK@6tH$1QK >Xq@щhҥ $ݩ4E*dɉFdm%}St~ ܄XzqUs<וnj ԢZuXJJlZ_rO&pԒpIf)}DtvEsM(IMQ8(JG "9F^K-! H-)`p#/S#:2Qι'€S(8k5~xmOEN: 48LS#CX4L玦.4k"lyoC~gH,ςk 2(RW-*# R(1Z#GYVmAhRRsZåApa&w^ 4-gi*.dX>xGx{Ҍ@/: Fܻk8 ‰FbsŰ pgϵ7us\kI}Gn!͔r,W}p np+MDa1L$.I)ҨJDS=%aDd˔Yb~Ck-7GDZ(ՇHя:B}i&+QKSۓFz1H\ &8X˽о3FD7F})ڀ]-xV}漹`#NgX)B> uj'3E@|CK]2ƳI))RiɪTRU KX\: ,"dZ)W-`T MA&vkWḀ'Z-HWVUrЩRt#0ʗf|ЉkWp1&DE0/_Wc6W/+1ѵQGADDAB;UDHsi}?n5q{ *bޘ"" ~5q{f\R$$*d֨K%)K,)q$HC%IݧC$' <X_TpzAb_2'ԫWT۲:]$FG2(Ob9c'0Ky/-s`P~*VL.RR<&Wܔui:*?téހz)611h},p319YӤI# pݍ'UR0`RJR J@)K7(SݱfP.jMj$n @*m3ȮU3S?jsH :X.vȥ/,X0. N^I&ɹQ?Z!]rɗHa?c\wFZgKS!}a%)HaiZjD*RDI+5iJR2TL?1Z>&R%Y=\]@PȔ|lfjKRh-q Cr]yoF+&P"="_EY8dLw7!+ѳ:;).iA~J9m WJ &nnI,W?S4 "^$"dߐWtW6li#M-U aԥ-,9yΒ%+UeϗZ*T e;Ez,FUեA3d!S%)OI-L@S ;舵J)Ț'K% LMi9Zv17JHEj1AF{h:B䝌eYF[cW]jbNf+S*^1 ߝ5;~+ ҅UnC]RHЩBzىZ܁A#rsdhƱ.~`3%_Z-==IɗæIBG i hus!FD#KӮteU nPCII$xFR!ZN;byAEhI?V6d/LP:2jJBYJN<~ԈtT UTyʞ2t;XEL2tZm8OY0 TZ⩋bl#6e=/3Kx/c@8:P掱'ZsdmJOxT Jdϐ5ZRA*b) (B"-),|E|F1#e~"¾#ҵQGADDAC_n5?CK*>0.vPhRtdMp/M;DDAizɚr"bu 3˘%MZOVA$T]r/ SMsSD驘D0#ND VHKv:r͒ϴoYu/""ؘe5WFDV)@!0McT'VFUhyhBH,(52E.0ӵqg}ԿoYu/""MYV+\U%zWYK#NŝRh>ӵqg}Կ C#)V&L񄾻Luzi3?cA/OG_ˆFR T{z8O9:)2AIYkZ2TEiZJ-hQBX,A$ ڈi<Ӟߞ[l=zJ=B>JOj4hey_'DBBjOkhfhLQHP2gN*T04G&d4D٢zsZe ySnpڴIR?LNeΒl"; stM?b%R'j(sJPF#'B<q.Wq&ksI#=]T/z7үd35KFRQ35^3jU3fKSJPR!JR3z[RyF{^)9b1pgi".$fHv$*SAU3KI6}%2-%'&P<"_i&"Kv-hhe-~=,LӐERg?sI e%@0AZ^TO+DJ%+'R4;ʩ}ORxhLoIǗqZ>B͍Vn䍣kڠt-ݿy%TT(AaHQ)77/&j6j pootiWF,#[-(*UNj!OH^*I}ֹܒcAMjf Y2t e=[j̙,iu!UPAZֶj殑R$$K$D[ iWDb+VOy4&ɖޓϺ+T~$ƨTJ,|Gb_h7TѲvD[+8#A+L: 4RS_zKLNZ Q {:M_Th_*haT$p0i:le)iigL0nRuyڄLSIaצ9JJ&I͚',K pI;Z'>J6XuytM7;XbR}Y=b4('e d9<cC2Z`_]%IziK`ȎӠ u ąLX3T;xQ7KjNW5SEJ`) H JR)J@ &oS4ukrvWdktIuCcQֶ|B37x zH;T?ph2PRQ1*I(%@.#Fy52i ɕJZ: O̬}.E?iY6ػ?iM53cvYp,j$-q~}vzEbb }.S7TDbJ%XSQ ;[}zΚ)2- 3po}$zjWBH2KE2[WZrT)S% (.,f.|-# bU 2o7Q6`ɓYQyZR;n܌CU6liӮNZ*ZmM]"/r5]/i⣘gM"h,k,\k,y웎Xls恫 QvDZ P:i# 2DD娂BEe؅9W֩cę'Ng#2PԊ{#h5ZT:kugL+1rSH2TzNQ$ U,PZR\NӒԬ'IZ_"1ӵQGADDAC$F}HeGVl}&>{kƧeGAv{c1ږc%%D$\;}fitlj gISe\]eJ DD-ܴr{c1zRJ%35ZVEjD#X(H"`}#^zy4_^&$$nB)4"" 0TgSs֩LΨ BJ RxE.4&NZ3L -&z jRKVmDDA>ݦ L}*z:|2σX ZRjSPZDp,]̗"휿ˌꔵ.gU&Bj4ޔ⥨Jw9 F?۹9ӗ "8#)39eLpWX;Ȍ/yܸF8@=D*XwdH8AqaZGpP_p|ڶ4 %U{Jhh鴈 ~ԕM{JB(?* a`$NL%[JT-kT?_G1Geϛ*kZ Y+F:\C'P̙VHJC>-dщ#7i it.T/Îu}yRi3eDvg(2JL@\z-NKC@qOS:ㆵvΏ Z 7ݯ Kߊ|q \?,BH6ׯ4S'ۘ|[MX8ddLk'iR%0X-)'-TuJf-R– JSrT̓ɕ@IeKP%C)@c`$d0dJw2HԸke 3eɟsdy s?+ߋdY%SM)JI܋g SjQ)Sz I$8܋gՔ gSȩ"lP5!I*sPqj4#jY2T KSLiXg>4IѣlDm*3Gc ]$?S lbRz6a=9=tdO"&'i_Y=5*vooKLՓ}ڃ[nI_5g7;XDZWJ&JDD 9KZ NyGZNFp&V JH%&bA]@D^9d贡ԦbZ"}5}RcVHeƞZXw(~gALO^>R%;Y* ~(2$. cWr<C#+ح_53JRf$)Z=Z~^ #PZ&i+%r$)J 65阩ғ$5SVHKZGZDj))H+S>)eT0Ȑp]Eaj}\O맸 Kk-UnSKwDDO*}$5 T釴"c5NIRe-j:9}Dt4KPS䕡`^ZEOQТl )Ldn'Rϋb;qJɣ33C{7[촓O*rI-*#!1^foVI DPjVX GOQ6TPֱƃAO>dM#GMRG 8+[)6lpGڝ>l{ !sl2Neʔ/`XLj=T%媊%g`XFL"L̚dEi@IeLZ֝8PȖjBԠk/ {"bǮVh_G+RKԭ4rBuSF:=F8@sjjt7qtE"F[-F4KY85ݟrlx<@/}&Q'V עa]A 6|J$o\ p .2 )D͐-NBN_R5zER uJR)*а#tty~sd\Dǖ]nCh~q%+ )/0ϒe ZD[ѳ i_O_&-v,cc J&KLD!.S▹H$:4te5ST2A(ɋbPA T%}$Y:=(G)jfz"]5J"̽۹,;hD΄Zu5Ю9s&Mwe07D\#t@bs\-uHÍwE/ح~ S<ԩ*H fplZ=J( LY\YQ+DR 癋tL~S%z¡OgI*ZڵInZ1Tc3G^* ֌:>}p5զLBC@s}\H2bC 7y ?!<~XG2lنVN5. B⩋cJ\&)~BSFzR&u>x֗тw-krdUq %g K-^tMe6ח喑n@jЄ<)V]6 -M,Wo ԥ)J Iff{'+RLGbYoYAL<.FL4Ė봥`TRT%h _CbLgu?Y+e1nxe: ZNGS2R&p6hS. \͏n^YŇsu_GgI4L%Drp"a)b^fiY*J] RgJpCM{;qԭy ĥOPꬎ6t7ܣCAq6\Λ2ւg":-m77H4T IY6K_hK1PJR7':CKQ"ZukIeNV$V) Ry)jЂU=(EhB[f%v.^>zI& TBVPA$#[V}+SvV-[jZA/mc5.Of[=]Қ;%,TʼnpHqOMZvNIXB~%P*tҩJV-s$%meJ c`A3:!hGt\Φl)kKABQ?δ%Ԧa:9_p4l_WcԵQGADDAB7SDj:E2R ^>uq}Կ>gaE:II !,}T}]7,_yu/uq}Կ+_?<tË""uq}Կ$&"x,Ckb1SZ_?<E;x<ﺗE}tË烮q~DDAx<ﺗA:_/oY:_4WM8|~x:鿇4,3</yO@ 2uE&ZfQ"hIIS) RF^nH(Q2RҢ$3A 'ZA*.tr.34eꔲfurT)C,.)D%)'`h? ;׎NI6gpcxrwND*\%sJ35 7}oI+BMVM}S;xhტN6f $`v Re:&Nj1*LʖOM9sf fW (STgKxsgΝ VGjZ(dLY"F$a<_Ni,3Y9jusLْȰJPHd )r9.TΪpNhO>5zyI ]iZ1йjVb De]L#~.-vǛ+̴n .Q.vȜטi؃0Jt _U//Sk_ 뎘K{fk)= J$ pA؈Иdt5ԫǛ.Q\J@Rr>Hbdզ\%)KT2Ix'GX:B,鐡,)PRR\cu4ܻ`]l==l3ayk6Z˷މ X[3I^=NkuS71 H"k[zlrDuʘJeia7,@qS^*R .D:d LsTR $TaQ҉ɩ*IJQCRԩI!ThSGSzI\)j+ISV F"-hҊ4f B}Zs'iUϲ'~R'x֪mF"@-{\Zg@y]dE}cvɈNfADKÚ`=r%s%Fw;S1hVHӪ( n3k.L˖\itj2WJ~H7N^PZN̕1R1T(`Xڕ` ' 8#8:BȰE c3(]cQIjPH*Q`p/*a lȞl"2\2JҪ1 T) ORMϰQfLQZ3!5M!)%Rl@4ꆝkƒrO5>ڮ oN<d!f2y}Sl%%y2 5V&۰-*3E&΋I;Tw'1M&IJNI5(bTK(O0}su #G3Ե=sfNZW-!H #i&S:UnS Jk9j T;qؘ#`Z,_DM'e1௵If0flݐ x_RNi5 r()JR% 2RDLB]?]O7G4Z)RVJ-aҴĥC`A)]D۟^ [#̔o 71 "]@8U"pymCH<-_^ֿ~]q cY5?c_nq"|%hLĭ *HP!@ cAcO&dLju.\ V(Q94$%"3&l鈕,)k.IR2aG=Y=6Z'Lnue+O)%f+H4ܸX.C|ee6LD ɒ@ 97eoDddH64Fӂ'7W9]}zD(7fv+C'*jPBda!H% >0S2Zty BdHH% I3^2B9I)VJ .Z1i evEZ2D\9] S$!mb(X`6cJ*J'K% ,^Ϻ*2f_?4OJu|t)}1UDڃӑ&k3: F#;Tm&"E=裉xsCEHX%/W^5UCAF1$h6d夤K* *X*H+RlS7ʑ \HIPӕ˙Hr$l!uU`sW3UK d& sxֳ,g{3&fPV)f.V1zۿd_>TղZR|i&ҕ$͓94̒%\]*IT.cNJ]ϰ~GV&:yKJR⹋!Ē 97VoU+crW#CFvrO) ϴ l`і/mԱU4H4dkVhSUb4d$_X,{Uտ2&MjT.>Lڒy tuB 6LkYXĴJ\$W1m0$(GF@gE*t=i $s14sWtTy̕5k*RHqdLlqִ3X獲rpB[6͆ fBڕusU:jTA H JR)J@J@gA-iDJd]T9T9Ф,!i;I GMrrx@"V p$ӑo$%pkvF&m?J'D@k@)~ۜW?S+Lg'C3%-3RV(`u=&For&Y^J9PJH\JB J2r*X*\#$G5&FT lԖTխIӃe+ʀ;%vl얍7'eMJf7Nv9ģDp2d ܛ"]·tFD\-5%z)RS9m;W#_'RT1RzBK֥I"D/u2RZZ%'OeHB-K!)JkJF+TiL%i0W)KRHV(P0.dҭKRBL1(X8 b%A aXY4/+1յQGADDAC_n5?CK*>0>UԄI*9YQ}Dk""7'O!3̱!GDfy u`+ت¯&_?4Dk""ODsEk*5*IAe$o-dRKRe\0Y&r$pj0Q;\𒐉*gaFDT2'!+2SQO.H t>*e q>K> L:&c=׏'~_?4Dk""u3&b)BJ5x@Y\$SJ/OխT2h ûGu ޟwAWYM6z~h:OK.n4,3 }~d%Tb! 1>s܏˅N#_+=TΫgߢt/ K }/IRK&JX4Ů )*J1綫_ pm?-;ce#uCju~"~'`8: ЉTxFHBq1*;uHfLɤ0) VBRhdRu&@?R8$˘PNG8ĭ2& Mt^l &8.WQh_krO*IUFT6Ut}^?Y)|J[I~;O=TڹbHJBQ- !% KI$%]Lz6<^/Slǵ_rmAASî[̴Nk2nh dKj:@YP2\{=$L̷<5_̭@ϯ2&,׫ݢ +Ө)aO*ZUSޮ* ܢuԕ)*BJ0A KVRJ%zue(IRl-ڞ 1guɟs/@2!\V[/l{p`] Cӗ#<:3R̔$"QI(=I>fW/L M lݽӧk~WBG]7tUS4|F7UEOxlfe>gG(" dTLՄҔ̕)$X^P J\=aj+٫H!*EH& %/f{<ĉViС:S"v>^M?t]|-غ,5TB&iFpxM$NdJc 1uRL  A'O9Pэ$:'xVzD#c&iTeug&TJI \+|&^X&Bm+ /soZE])9Xv#o$A'VNOUD%GB(8ns/VmvG7]UQa`}2$˔MFZ"_S)r o_ѵ%:ry޹4{u/OW>vi1-d(BJP R l}&8+|i{^mwڝ>l{ #~ʵ(*ou.y㵾#c}A6H 2Yk=$%AA>axYäՉMm5?\FxR=:% i/]bUnMK3e-3%օPRT)%`~gXOUҔ2@+NJV"ѡYҹKU8K}ɱ@dݗw6^cs~C]·:Zݿyuj }&S;VD]B%v $}6|J'._Tdؖ ޻G}zFL:$}..w)`7$U^_a'mp[zj+G(g&% H/S5a LRsb"V*RtYKJ5qL0$Y IDE~$Od(OJO8oAwDg/}ۃe:F[e|Y|ﵷ+>G_ڭv04;% D=zP/{=1;G>b/L؀ _{=ƗKuj@ͬ54?S.It E?:? \E"pvhZsMDdKJQAI LQ$&H7 h#&RJjM8 -reVqb3o/خOCzY.Hvt㜮{4st%S g/tff+T?+]ի_',N6WT'o[Pkxa>fKu^:|Z:R݌ &tUbdBOZP=JȷXB.O"w Hka0L083Bk[:<)4g=:'Q!rX=,f|ڟU!7fɕ+}'S-= =_ {bzRW["zBfS *< :tA{gnF2oZP喑nFҗc| yVJ]VW`hN!j5Xw z$I!J5k~E}`WvkVڊnx3dzQ*ROBAwfs]=bnZtK\M lUq:}:jĩ.Y/͚,a($졘_v6,;&CbdO+.Q5uhJ_HKЀG5}[Tg̡hGx{NSĠ M)JRRY)J@  zT5FGNTd^YͣQW;nUAASr8pv8%8ޗN*\) A[p o=$eAA9MUO][fxxО~J <R^WXv3F̖̒JW-AIP  NGQx9R +LTruaKȡIbBo]+N-ckV}v۲D$,`\]vzd{:o9ͻFENd%K3[)'ԦrIA~Dٛh'= 6u}h$uu *Ôbt%]GI^ (~D3ZRkJ:j',%8JDr`C -K2!US1@R8R kN"-؅/+1K bֵQGADDAGub&#DezLb&#DezLb&#DezLb&#DezLb&#DezLb&#GJ'gJ5&QLI)RPba΀ 0}>t\.hVhN ReIF`% AT%4HT+ gAtuRi$%V%`"a%a*Ƅ]:djU%}"!ezJAPfM') Q{= Z0HjTKөaUMKiA,: \* H?J+A2T(t%hR5/rC1xIRemJ4$(DH+Kx8KX<1*!3&jVVTJM+B)%%!-?J VeNNZBgKZW)h,-qg""ʟ)3U,BH%DWv%R=:n'Zt33dV ,n@@!*QiiL1.R28PZ"?UJ*R%J+"2"!gT<+U-_JQK$"lkdJe:*bqQ\Ţ!Jzd\ ]jx:-BP&%M5i(iXRdMJYg%2B"" niZJ0OHM0KYT%xMnRCU'*f:Y4T.fzɨ] Gtbʗ8&6djFKk12&R4N]SթeRDZᅬ`+龚XLsiL%20(@U *$p.~$ftDԤL'O*A4^Q2źwAcP\&ZviV#O!GIIQHXsMt2ՅLx":*JDu NJxCDD]"%&nPȚhUD(X+pJŚO$*Z$Kdh2eOL49+{r~Mѽ>ʕ]T]rt-Rq.:^ Z4z4˝;FBuITpAx"" JrTSgt•0N2@N.e9C &әej\&%sROOHR:&pN^'K"@tf WX(.-@&*`,tڰurΟ_'T{&DDz.LYseD JN :8.NUO%Akꧥk.GRiT8.^ uq>]+(k$IT'DV\蜟eKBK*K$-V઴b4X ꔥMABH: !^ KjBՉjU,RZDzĤb@DIjHJ륤! ̖HXYU5JעI̙\4BL 咕p&ɣ<<+N9=D7S>l~ rե&T%rm=r)t{A|rCNGY.IYLH= 0R"yM$$K jU5 BU/RhB| `mp\yD"" gGzKB¤ʐ$2d) :iɖ:*|OIgtl2̙s#DN2%Z̤U)U+\H$DD9JY1 BI)PUpn,_7:6^I5ZJ72itR hGKH_NtBdJ&.H)|JKՓDDBVŏ0^#TFT>:ReKV,iz"ЎUѓ5h\]_ LiRNUՐ䈈0KTr'JJgu -*\))TRg)t):Y ";M+/IL:z4떱+!$$eDDA%}it7\|h@EKLԉsȐzɂbgWL% fU-2@,L.B&%NAOU0XkjkpDlh&^ 2UMe4B>~bhƒ^Z̚TH'-*Rue|${""Rth鄤TH\!aBT$\iV/;&GIT6dUt@(njh5'EYQT6RHJXL%b$zI K_ PcR\ia$ d"" NGLR VE(R&fdԤT:PR$u%kZi`&bCR(i0ːPXu(ө*lILI@Q*%YRd)J%/ QKTp""O)yXK-JBtŚTT8҄%3u]BhD:R'%Юd$L@A(@P .N~lKpRՙWQ8֧{ɲdLL ^f(R%G D9nSPR4q5hZ)4 zl$êB0醧K& YDUq8A~I}jS8P+O.X=\ټJ7} i<"TzFnD9FiD (4܈9辍#eZAdrI"e` *dAѳ&,^\9sc!s&%5^K^0t=&|NS:digɔD"z@u|/j>FS4ԓDTJy^d(D&ŒKC ޅ:T LxR~E*tŠ,uR.jS%Q'OLLJ] ó>4JMZ]J1gi$1i 6XD[F \TC%I2D\ĕ9&z)*Y6""^bGRb6Yb͖•))PC: @' *?TVL3O@*Ԥ.SI0mD覧Tx\IQR(L+Qe U/$)" ׫, 'N\K//I5٘"" = 4pZ&DRM$$&!ʘ,DM+DB$%J4KJ˫ NQ9'S\f-KQ*hVBi:D%, Vă3%t)2QbaRRVv""ODhiLrr }Xʖ&5ULHHZH 53: ՙSS7Frgx*WQ9IBTI*)J hKYоZu򴺅iXJ<ɜb:KJnTlкui$jT*DD]jԽFU(YsRH6rDDA2t] ZJ-bL|i BtW&f@H )*C#QdJ9+-A(+BeWU3TbPL4rS=0)@0JTDDL=1#JΝif MQRe UjA=:$ %cQ*T=4j1OQ.t(!d!!)Y3 83PX1>GCief3N'Ks(lQ))4;Tl ]ъ!d R$StA@#*HS*Rd*bjR,0_2xLXBJ_$yĞwl-'g:FA)/2Am<׺7 إl3i'OY5K JrF\գxhXΔZ Η%ԕҀIeRIht\ hjF)Zɝ/N$+H6.|wl"}OGtWG/KRLt&cR$ d YJ :ɑBtL`GFJMWQQ@?NѕT5R\( ( 88NO1%ޟK[Lp}+iJxn 7zsQtK:.,p(k&U.dwЖjFO͚VR$!)11_jڪU=)񌮤~؎Z%AЕ)A4%!J-'LGi>sf!sCMZuLҡPRY!:+U,a)BuKʜQ+dR1rtک)C1ZiW-fG˞(-U$&QAx>xAu9pLZS0M JBRL$ hJBC2XRDDzOI :E2\GP1r]AH%jHesUɓt2LT)a HJ%!J6}j]r`]H …)S !&9pQ}q_X' J:L)*8DDH}jU944YW,R17T@ 7XZus%uiRu}ZeS]5Ѐ3ѵQGADDAADDADDAADDADDAADDADDA}4"ʓѿj:Mҵ1Ζq],BM `\|}<ϵ3!;EirDt5R'&TRDDA j%Z2&i[Mӕ-*2fϖ TBKRHC[ߡ$ϕH:tqZP)6RX3%%&L)RӴzi2gLL6PKL5% BNRզD$W)SPgd"\8SZ!OFtT#[8:zT0I"bAP^K?D(l&\AkViJ6ZMAQX;;QӺiX&D/JB&x9 R :GFirҥ'HID%êNHx"" zO]s4g^d.k1r"N̛Fl!3_Z\%J(1$EOZcH.iG@DT%ʹ+hkbdM2 8 QӨ-H3K ةDDOLz[O.RFj! TMTЉ_ 5-bZ_F̙Lq9y(>bj!!"MJC@P>-%:2!Se\-hYRn7:ydZ5 QX]lS@QfI!0DDAt0C+Q'C=:TFLf ZH ,\:/aR䮣I3Ө%iJ\.j !$!SK6lDj ӅMJ J QSjqchTޝn^r`OlRRETT*S0*b!@)L XM/GtW[x,3dRU,^-FgLR B"DʕJ*,@Pf'b31S)CMMByU!DD֟C &3ȞdQ$iHS)21{pމҽ#WH̐u3L^Br.-2S ($K0ΐZYYѺL *$t%# )y6 ]zYz57HW6YS!s 4I2DD~[U&D )ku2P׭HJJti)E.@$S~Iٚj%iЪ\%bA7 Q) Z:K,US\LJzR,r_ڏKΖtTVgMrTBx"" uS$'LU!$Q i;oJB:5@IRgk(DpeZh3'萤Ki A3zFR2fR!%JRLJBE$""J)TT*aILՂ 3c L:qyZQWڥ\`%^z/^:j> <J%zyM2kR JPxAuiL3%L RB@ DDAL-tԡ35S֙I)@TՐ46<'؅a'J)EdL2 !$f-R' ,♳-EEa -UРYvB0CcI&G%nU})J+L T!AA b.9cOM,\8 `,49AA\X%* ,H,yG I yQVu($*oV x>Ydtɔ9ۣ KȤ{s]`MH K<il*oBa}ߕJb,+ IzkRJ VJ晁AicMK(ҧ\ 7>迵39ʔ$JLecG$][& ZT InJ"8R"NRb77oF7#QNR:=:&$bW>LcL&ۈoK3uR(j$s剢ZLEOH~CK蔥.JTPKŲ"s:S]6Z/S5HY$uV|6*`tj  \!D.mg!%)PnT>dfcLZ:ŀĠ ͡x""  "" ""  ҵQGADDAADDADDAADDADDAADDADDA}Dɺr%ɛ/eINS WP$ Re IRA/xx/M&֦dNHx?T eU30K]HNզTU̙6be 82A $- 5rѭjg&rdֽ,,!d `DNJDP* $2jIc¦e`A]Vu> irɡcCL 4{gtٖ'h4N0 L޶Z<IqBPEC. #=,R@\hS2dU9 A{R#O]G:bB3O:oIaR5hm8!E$8x"" ?D)ʎSԔjV/PRPր5dΛ'HLN6aTY;M?LhRiJz &ޚnhĝ,fIR%d(B+H!mRŚ."se}"TXtOIG\7MwSf&"_D"J<ueHV-)T>stream endstream endobj 276 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.235 Tw 10 0 0 10 70.8661 724.8299 Tm (\007\017\b\024\021\024\n\017\004\036\f\022\017\b \007\026\027\027\t\b \024\ \023\017\f\t\r\026\035\017 \f)Tj /Span<>> BDC ( )Tj EMC (95% \007\024\r\036\030\017)Tj 0 Tw (-)Tj 0.07 Tw 0 -1.218 TD [(\021\036\035\034\027\t\n )0.5(\017\027\021\036\030\r\026\035\024\n )0.5(\(\212\222\) \r)]TJ /Span<>> BDC ( )Tj EMC [(\r\017\007\036 )0.5(\024\021\027\024\001\036\027\017\016 )0.5(\001\026\027\f\024\r )]TJ 0.195 Tw T* (\(\210\234\). \025\024\035\017\004\036\f\021\r\036\027\027\t\036 \007\026\ \027\027\t\036 \f\030\026\r\027\017\r\026\035\017\f\034 \023\031\021\036\ \n )Tj 0.091 Tw T* (\r\t\004\017\f\035\036\027\017\016 \030\026\027\017\006\t \f\030\036\007\ \027\017\b \f)Tj /Span<>> BDC ( )Tj EMC (95% \007\024\r\036\030\017\021\036\035\034\027\t\n )Tj 0.345 Tw T* (\017\027\021\036\030\r\026\035\024\n. \221\021\026\021\017\f\021\017\004\ \036\f\022\031\033 \020\036\021\036\030\024\020\036\027\027\024\f\021\034\ \f\030\036\007\017 )Tj 0.154 Tw T* (\r\022\035\033\004\036\027\027\t\b \r)Tj /Span<>> BDC ( )Tj EMC (\n\036\021\026\026\027\026\035\017 \017\f\f\035\036\007\024\r\026\027\017\ \005 \024\006\036\027\017\r\026\035\017 )Tj 0.18 Tw 0 -1.218 TD (\f)Tj /Span<>> BDC ( )Tj EMC (\023\024\n\024\013\034\033 \233)Tj 0 Tw 5.83 0 0 5.83 127.6241 655.0919 Tm (2)Tj 0.18 Tw 10 0 0 10 130.5391 651.7618 Tm ( \021\036\f\021\026 \017)Tj /Span<>> BDC ( )Tj EMC (\017\027\007\036\022\f\026 \020\036\021\036\030\024\020\036\027\027\024\f\ \021\017 \(I)Tj 0 Tw 5.83 0 0 5.83 282.3936 655.0919 Tm (2)Tj 10 0 0 10 285.3087 651.7618 Tm (\). )Tj -21.444 -1.218 Td (\215\030\017)Tj /Span<>> BDC ( )Tj EMC /T1_1 1 Tf 1.844 0 Td (\032)Tj /T1_0 1 Tf -0.01 Tw /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (0,1 \017)Tj /Span<>> BDC ( )Tj EMC (I)Tj 0 Tw 5.83 0 0 5.83 128.7558 642.9138 Tm (2)Tj -0.01 Tw /Span<>> BDC 10 0 0 10 131.6708 639.5838 Tm ( )Tj EMC (>)Tj /Span<>> BDC ( )Tj EMC [(50% \030\036\031\035\034\021\026\021\t \f\004\017\021\026\035\017 )0.5(\f\021\026\021\017\f\021\017\004\036)]TJ 0 Tw (-)Tj -0.048 Tw -6.08 -1.218 Td (\f\022\017 \027\026\004\017\n\024 \020\036\021\036\030\024\020\036\027\027\ \t\n\017. \215\030\017)Tj /Span<>> BDC ( )Tj EMC (\024\021\f\031\021\f\021\r\017\017 \r)Tj /Span<>> BDC ( )Tj EMC (\f\021\026\021\034\016\b )Tj 0.074 Tw 0 -1.218 TD (\f\030\036\007\027\017\b \027\026\004\036\027\017\005, \r\t\004\017\f\035\ \036\027\017\036 \023\024\f\035\036\007\027\017\b \002\t\035\024 \024\f\031\ )Tj 0 Tw (-)Tj T* (\013\036\f\021\r\035\036\027\024 \f)Tj /Span<>> BDC ( )Tj EMC [(\023\024\n\024\013\034\033 \022\026\035\034\022\031\035\016\021\024\030\026\ \(W)12.2(an\245s \n\036\021\024\007\).)]TJ /T1_2 1 Tf 0 -2.436 TD (\022\r\213\210\f\001\003\004\003)Tj /T1_1 1 Tf ( )Tj /T1_2 1 Tf 4.549 0 Td (\212\002\t\217\220\004)Tj /T1_0 1 Tf 0.141 Tw -4.549 -1.218 Td (\200 \030\036\031\035\034\021\026\021\036 \026\023\030\024\f\026 \027\026\ \005\007\036\027\024 3040 \017\f\021\024\004\027\017\022\024\r \035\017)Tj 0 Tw (-)Tj 0.363 Tw 0 -1.218 TD [(\021\036\030\026\021\031\030\t. \215\030\024\017\r\036\007\036\027 )0.5(\f\022\030\017\027\017\027\020 \027\026\005\007\036\027\027\t\b )0.5(\030\026\002\024\021 )]TJ 0.047 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC 1.253 0 Td [(\f\024\024\021\r\036\021\f\021\r\017\036 )0.5(\022\030\017\021\036\030\017\016\n )0.6(\r\022\035\033\004\036\027\017\016 )0.6(\023\024)]TJ /Span<>> BDC ( )Tj EMC 16.447 0 Td (\027\026\r\026\027\017\016\n )Tj 0.044 Tw -17.7 -1.218 Td (\017)Tj /Span<>> BDC ( )Tj EMC (\030\036\033\n\036. \215\024\f\035\036 \r\t\023\024\035\027\036\027\027\ \024\020\024 \f\022\030\017\027\017\027\020\026, 2955)Tj /Span<>> BDC ( )Tj EMC (\f\021\026)Tj 0 Tw (-)Tj 0.323 Tw T* (\021\036\005 \002\t\035\017 \017\f\022\035\033\004\036\027\t \017)Tj /Span<>> BDC ( )Tj EMC (\f\017\f\021\036\n\026\021\017\004\036\f\022\024\020\024 \024\002\024\030\ \026 )Tj 0 Tw T* (\(\217\017\f.)Tj /Span<>> BDC ( )Tj EMC (1\).)Tj 0.037 Tw T* [(\221\035\036\007\031\033\013\017\n \220\021\026\023\024\n \023\030\024\017\ \r\036\007\036\027\024 )0.5(\007\036\021\026\035\034\027\024\036 \017\031\004\036\027\017\036 )]TJ 0.04 Tw T* [(85 )0.5(\024\030\017\020\017\027\026\035\034\027\t\b )0.6(\017\f\f\035\036\007\024\r\026\027\017\005 )0.6(\f)]TJ /Span<>> BDC ( )Tj EMC [(\007\024\f\021\031\023\027\t\n )0.6(\023\024\035\027\t\n )]TJ 0.295 Tw T* (\021\036\022\f\021\024\n \f\021\026\021\036\005. \200)Tj /Span<>> BDC ( )Tj EMC (\030\036\031\035\034\021\026\021\036)Tj /Span<>> BDC ( )Tj EMC (\227 67 \017\f\f\035\036\007\024\r\026\027\017\005 )Tj 0.184 Tw T* (\002\t\035\017 \017\f\022\035\033\004\036\027\t \017)Tj /Span<>> BDC ( )Tj EMC (\007\026\035\034\027\036\005\001\036\020\024 \f\017\f\021\036\n\026\021\017\ \004\036\f\022\024\020\024 )Tj 0.067 Tw T* (\024\002\024\030\026 \023\024)Tj /Span<>> BDC ( )Tj EMC (\023\030\017\004\017\027\036 \027\036\f\024\024\021\r\036\021\f\021\r\017\ \016 \022\030\017\021\036\030\017\016\n \r\022\035\033)Tj 0 Tw (-)Tj 0.196 Tw T* (\004\036\027\017\016 \017)Tj /Span<>> BDC ( )Tj EMC (\024\021\f\031\021\f\021\r\017\016 \027\036\024\002\b\024\007\017\n\t\b \ \007\035\016 \026\027\026\035\017\026 \007\026\027)Tj 0 Tw (-)Tj 0.171 Tw T* (\027\t\b. \230\026\022\032\036 \023\030\017\004\017\027\024\005 \017\f\022\ \035\033\004\036\027\017\016 \f\021\026\035\024 \024\021\f\031\021\f\021\ \r\017\036 )Tj 0.184 Tw T* (\027\036\024\002\b\024\007\017\n\t\b \030\036\031\035\034\021\026\021\024\ \r \f\021\026\021\017\f\021\017\004\036\f\022\024\020\024 \026\027\026\035\ \017\026: )Tj 0.278 Tw T* (\026\002\f\024\035\033\021\027\t\b \027\026\004\036\027\017\005 \017\031\ \004\026\036\n\024\020\024 \017\f\b\024\007\026, \026)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\032\036 )Tj 0.286 Tw T* (\027\026\004\036\027\017\005 \022\026\021\036\020\024\030\017\026\035\034\ \027\t\b \017)Tj /Span<>> BDC ( )Tj EMC (\022\024\035\017\004\036\f\021\r\036\027\027\t\b \023\036\030\036)Tj 0 Tw (-)Tj 0.275 Tw T* (\n\036\027\027\t\b. \200)Tj /Span<>> BDC ( )Tj EMC (\022\024\027\036\004\027\024\n \017\021\024\020\036 \r)Tj /Span<>> BDC ( )Tj EMC (\f\017\f\021\036\n\026\021\017\004\036\f\022\017\005 \024\002)Tj 0 Tw (-)Tj 0.181 Tw T* (\024\030 \017)Tj /Span<>> BDC ( )Tj EMC (\n\036\021\026\026\027\026\035\017 \002\t\035\024 \r\022\035\033\004\036\ \027\024 18 \017\f\f\035\036\007\024\r\026\027\017\005 )Tj 0 Tw T* (\(\230\026\002\035.)Tj /Span<>> BDC ( )Tj EMC (1\).)Tj /T1_2 1 Tf 0 -2.436 TD (\200\002\f\210\201\r\b\t\r)Tj /T1_1 1 Tf ( )Tj /T1_2 1 Tf 4.989 0 Td (\212\r\006\r\214\r\b\b\013\216)Tj /T1_0 1 Tf 0.059 Tw -4.989 -1.218 Td (\200 \n\036\021\026\026\027\026\035\017\036 \017\031\004\026\035\017\f\ \034 \021\026\022\017\036 \023\036\030\036\n\036\027\027\t\036 \022\026\022\ \023\024\035, )Tj 0.223 Tw 0 -1.218 TD (\r\024\030\026\f\021 \023\026\006\017\036\027\021\026, \007\035\017\021\ \036\035\034\027\024\f\021\034 \026\027\026\n\027\036\026 \016\r\036\027\ \027\024)Tj 0 Tw (-)Tj 0.21 Tw T* (\020\024 \022\024\035\017\021\026, \023\030\024\021\016\032\036\027\027\024\ \f\021\034 \023\024\030\026\032\036\027\017\016 \021\024\035\f\021\024\005\ \022\017\001)Tj 0 Tw (-)Tj 0.132 Tw T* (\022\017, \026)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\032\036 \031\030\024\r\027\017 \026\035\034\002\031\n\017\027\ \026, \221-\030\036\026\022\021\017\r\027\024\020\024 \002\036\035\022\026\ )Tj 0.017 Tw 23.244 45.059 Td (\017)Tj /Span<>> BDC ( )Tj EMC [(\020\036\n\024\020\035\024\002\017\027\026 )0.5(\027\026)]TJ /Span<>> BDC ( )Tj EMC [(\n\024\n\036\027\021 )0.5(\027\026\004\026\035\026 \020\024\030\n\024\027\026\035\034\027\024\005 \ )0.5(\021\036\030\026)]TJ 0 Tw (-)Tj -0.027 Tw T* [(\023\017\017 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 2.466 0 Td [(\027\026 )0.5(3 )0.5(\f\031\021\022\017, )0.5(\022\026\022 )0.5(\027\026\017\002\024\035\036\036 )0.5(\r\026\032\027\t\005 )0.6(\f\030\024\022 )0.5(\023\030\017\027\016\021\017\016 )]TJ 0.148 Tw -2.466 -1.218 Td (\030\036\001\036\027\017\005 \024\002 \220\235\235\036\022\021\017\r\027\ \024\f\021\017 \020\024\030\n\024\027\026\035\034\027\024\005 \021\036\030\ \026\023\017\017. )Tj 0.163 Tw T* (\200)Tj /Span<>> BDC ( )Tj EMC (\021\024\n \004\017\f\035\036 \002\t\035\017 \017\031\004\036\027\t \023\ \036\030\036\n\036\027\027\t\036 \220\027\007\024\f\022\024\023\017)Tj 0 Tw (-)Tj 0.027 Tw T* (\004\036\f\022\024\005 \022\026\030\021\017\027\t \027\026)Tj /Span<>> BDC ( )Tj EMC (\024\f\027\024\r\026\027\017\017 \001\022\026\035 UCEIS \(7 \002\026\035\ \035\024\r\) )Tj 0.103 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (MES \(3 \002\026\035\035\026\), \024\006\036\027\036\027\027\t\036 \023\036\ \030\036\007 \027\026\004\026\035\024\n \035\036\004\036\027\017\016 )Tj 0 Tw 0 -1.218 TD (\022\024\030\021\017\022\024\f\021\036\030\024\017\007\026\n\017.)Tj /T1_2 1 Tf 0 -2.436 TD (\017\204\r\b\220\004)Tj /T1_1 1 Tf ( )Tj /T1_2 1 Tf 3.41 0 Td (\220\004\201\r\217\003\004)Tj /T1_1 1 Tf ( )Tj /T1_2 1 Tf 4.071 0 Td (\t\217\217\f\r\240\002\004\b\t\005)Tj /T1_0 1 Tf 0.185 Tw -7.481 -1.218 Td (\215\030\024\017\r\036\007\036\027\026 \007\r\031\b\220\021\026\023\027\ \026\016 \023\030\024\r\036\030\022\026 \022\026\004\036\f\021\r\026 \r\022\ \035\033)Tj 0 Tw (-)Tj 0.479 Tw 0 -1.218 TD (\004\036\027\027\t\b \r)Tj /Span<>> BDC ( )Tj EMC (\026\027\026\035\017 \017\f\f\035\036\007\024\r\026\027\017\005. \215\036\ \030\r\t\n \220\021\026\023\024\n )Tj 0.176 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC (\n\024\n\036\027\021 \026\027\026\035\017\026 \023\024\035\027\024\020\024\ \021\036\022\f\021\026 \f\021\026\021\036\005 \023\030\024\017\r\024)Tj 0 Tw (-)Tj 0.301 Tw T* (\007\017\035\026\f\034 \024\006\036\027\022\026 \022\026\004\036\f\021\r\ \026 \027\026)Tj /Span<>> BDC ( )Tj EMC (\f\024\024\021\r\036\021\f\021\r\017\036 \022\030\017\021\036\030\017)Tj 0 Tw (-)Tj 0.475 Tw T* (\016\n \004\036\022-\035\017\f\021\026 \007\035\016 \024\002\f\036\030\r\ \026\006\017\024\027\027\t\b \017\f\f\035\036\007\024\r\026\027\017\005 \ )Tj 0.108 Tw T* [(S)15(tr)-24(eng)17(t)-12.9(hening )0.5(t)-13(he )0.5(R)13(epor)-22(t)-32(ing )0.6(of )0.5(Obser)-32(v)-15(a)15(t)-32(ional )0.5(studies )]TJ -0.019 Tw T* [(in Epidemiol)30(o)-16(g)16(y \(S)-21(TROBE S)15(t)15(a)15(tement\) [27]. \212\026\035\036\036 \022\026\004\036)]TJ 0 Tw (-)Tj -0.033 Tw T* (\f\021\r\024 \r\022\035\033\004\036\027\027\t\b \017\f\f\035\036\007\024\ \r\026\027\017\005 \002\t\035\024 \024\006\036\027\036\027\024 \r)Tj /Span<>> BDC ( )Tj EMC (\f\024\024\021)Tj 0 Tw (-)Tj -0.007 Tw T* (\r\036\021\f\021\r\017\017 \f)Tj /Span<>> BDC ( )Tj EMC [(\022\030\017\021\036\030\017\016\n\017 R)-24(isk of bias in non-r)-33(and)-16(omized )]TJ 0.017 Tw T* (studies)Tj /Span<>> BDC ( )Tj EMC [(\227 of E)35(xposur)-23.9(es \(ROBINS-E\) [28]. \200)]TJ /Span<>> BDC ( )Tj EMC (\030\036\031\035\034\021\026\021\036 )Tj 0.296 Tw T* (\023\030\024\r\036\007\036\027\027\024\020\024 \026\027\026\035\017\026\ \f\031\n\n\026\030\027\024\020\024 \030\017\f\022\026 \f\017\f\021\036\n\ \026)Tj 0 Tw (-)Tj 0.097 Tw T* (\021\017\004\036\f\022\024\005 \024\001\017\002\022\017 \002\t\035\024 \r\ \t\016\r\035\036\027\024, \004\021\024 \021\024\035\034\022\024 1)Tj /Span<>> BDC ( )Tj EMC (\(5%\) )Tj 0.406 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (18 \r\022\035\033\004\036\027\027\t\b \017\f\f\035\036\007\024\r\026\027\ \017\005 \017\n\036\035\024 \r\t\f\024\022\017\005 )Tj -0.003 Tw T* (\030\017\f\022. 10)Tj /Span<>> BDC ( )Tj EMC (\(55%\) \030\026\002\024\021 \017\n\036\035\017 \f\030\036\007\027\017\005\ \030\017\f\022 \f\017\f\021\036\n\026\021\017)Tj 0 Tw (-)Tj 0.116 Tw T* (\004\036\f\022\024\005 \024\001\017\002\022\017. \203\017\022\017\005 \030\ \017\f\022 \f\n\036\013\036\027\017\016 \030\036\031\035\034\021\026\021\ \024\r )Tj 0 Tw T* (\026\235\017\022\f\017\030\024\r\026\027 \r)Tj /Span<>> BDC ( )Tj EMC (7)Tj /Span<>> BDC ( )Tj EMC (\(40%\) \017\f\f\035\036\007\024\r\026\027\017\016\b \(\217\017\f.)Tj /Span<>> BDC ( )Tj EMC (2\).)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 303.3769 396.0238 Tm [(\033\034\020)21(\223)50(\r\241)46(\024)52(\026)45(\024\232)]TJ 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0 Tc 0.014 Tw 10 0 0 10 303.3071 371.6678 Tm [(\200 )0.5(\024\002\013\036\005 )0.5(\f\035\024\032\027\024\f\021\017 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 9.561 0 Td [(18 )0.5(\017\f\f\035\036\007\024\r\026\027\017\005 )0.6(\r)]TJ /Span<>> BDC ( )Tj EMC 8.026 0 Td (\f\017\f\021\036\n\026\021\017)Tj 0 Tw (-)Tj 0.067 Tw -17.587 -1.218 Td (\004\036\f\022\017\005 \024\002\024\030 \017)Tj /Span<>> BDC ( )Tj EMC (\n\036\021\026\026\027\026\035\017 \002\t\035\024 \r\022\035\033\004\036\ \027\024 2545)Tj /Span<>> BDC ( )Tj EMC (\023\026)Tj 0 Tw (-)Tj 0.09 Tw T* (\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\021\016\032\036\035\024\005 \026\021\026\022\024\005 \247\025. \200)Tj /Span<>> BDC ( )Tj EMC (\030\036\031\035\034\021\026\021\036 \035\036\004\036\027\017\016 )Tj 0.098 Tw T* (\023\024\035\024\032\017\021\036\035\034\027\t\005 \253\024\021\r\036\021\ \273 \027\026)Tj /Span<>> BDC ( )Tj EMC (\f\017\f\021\036\n\027\031\033 \021\036\030\026\023\017\033 \022\024\030\ )Tj 0 Tw (-)Tj 0.384 Tw T* (\021\017\022\024\f\021\036\030\024\017\007\026\n\017 \024\021\n\036\004\036\ \027 \031)Tj /Span<>> BDC ( )Tj EMC (1769)Tj /Span<>> BDC ( )Tj EMC (\(69,5%\) \023\026\006\017\036\027)Tj 0 Tw (-)Tj -0.031 Tw T* (\021\024\r)Tj /Span<>> BDC ( )Tj EMC (\227 \020\030\031\023\023\026 \220\235\235\036\022\021\017\r\027\024\005\ \022\024\027\f\036\030\r\026\021\017\r\027\024\005 \021\036\030\026\023\ \017\017. )Tj 0.61 Tw T* (\206\024\030\n\024\027\026\035\034\027\026\016 \030\036\017\f\021\036\027\ \021\027\024\f\021\034 \f)Tj /Span<>> BDC ( )Tj EMC (\027\036\024\002\b\024\007\017\n\024\f\021\034\033 )Tj 0.454 Tw T* (\023\030\024\r\036\007\036\027\017\016 \253\021\036\030\026\023\017\017 \ \f\023\026\f\036\027\017\016\273 \017\035\017 \022\024\035\220\022\021\024\ \n\017\017 )Tj 0.009 Tw T* (\002\t\035\026 \031\f\021\026\027\024\r\035\036\027\026 \031)Tj /Span<>> BDC ( )Tj EMC (776)Tj /Span<>> BDC ( )Tj EMC (\(30,5%\) \023\026\006\017\036\027\021\024\r)Tj /Span<>> BDC ( )Tj EMC (\227 \020\030\031\023\023\026 )Tj 0 Tw T* (\020\024\030\n\024\027\026\035\034\027\024\005 \030\036\017\f\021\036\027\ \021\027\024\f\021\017.)Tj 0.056 Tw T* (\207\t\035\026 \023\030\024\017\r\036\007\036\027\026 \023\030\024\r\036\ \030\022\026 \020\030\031\023\023 \027\026)Tj /Span<>> BDC ( )Tj EMC (\024\007\027\024\030\024\007\027\024\f\021\034. )Tj 0.403 Tw T* (\230\026\022, \023\024)Tj /Span<>> BDC ( )Tj EMC (\023\024\035\031, \r\024\030\026\f\021\031 \017)Tj /Span<>> BDC ( )Tj EMC (\007\035\017\021\036\035\034\027\024\f\021\017 \026\027\026\n\027\036\026\ )Tj 0.278 Tw T* [(\247\025 )0.5(\020\030\031\023\023\t )0.5(\f\021\026\021\017\f\021\017\004\036\f\022\017 )0.5(\027\026\004\017\n\024 )0.6(\027\036 )0.5(\030\026\035\017\004\026\035\017\f\034 )]TJ 0 Tw T* (\(\230\026\002\035.)Tj /Span<>> BDC ( )Tj EMC (2\).)Tj -0.049 Tw T* (\221\021\024\017\021 \024\021\007\036\035\034\027\024 \024\002\030\026\021\ \017\021\034 \r\027\017\n\026\027\017\036, \004\021\024 \235\026\022\021\ \024\030\027\026\016 \023\036)Tj 0 Tw (-)Tj -0.027 Tw T* (\030\036\n\036\027\027\026\016 \253\021\024\021\026\035\034\027\024\036 \ \023\024\030\026\032\036\027\017\036 \f\035\017\017\f\021\024\005 \024\002\ \024\035\024\004\022\017 )Tj 0.055 Tw T* [(\021\024\035\f\021\024\005 \022\017\001\022\017\273, \f\021\026\021\017\f\ \021\017\004\036\f\022\017 )0.5(\027\026\004\017\n\024 \031\r\036\035\017\004\017\r\026\036\021 )]TJ -0.03 Tw T* (\r\036\030\024\016\021\027\024\f\021\034 \020\024\030\n\024\027\026\035\034\ \027\024\005 \030\036\017\f\021\036\027\021\027\024\f\021\017 \(\210\234\ )Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (1,5; )Tj 0 Tw T* (95% \212\222: 1,1\2262; )Tj /T1_1 1 Tf (p)Tj /T1_0 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,006\) \017)Tj /Span<>> BDC ( )Tj EMC (\016\r\035\016\036\021\f\016 \023\030\036\007\017\022\021\024\030\024\n.\ )Tj 0.18 Tw T* (\215\030\024\017\r\036\007\036\027 \n\036\021\026\026\027\026\035\017 \ \020\030\031\023\023\t \023\036\030\036\n\036\027\027\t\b)Tj /Span<>> BDC ( )Tj EMC (\227 \023\024)Tj 0 Tw (-)Tj 0.125 Tw T* (\021\036\027\006\017\026\035\034\027\t\b \023\030\036\007\017\022\021\024\ \030\024\r \027\036\002\035\026\020\024\023\030\017\016\021\027\024\020\024\ \017\f\b\024\007\026 )Tj 0 Tw T* (\020\024\030\n\024\027\026\035\034\027\024\005 \021\036\030\026\023\017\017\ )Tj /Span<>> BDC ( )Tj EMC (\227 \030\036\017\f\021\036\027\021\027\024\f\021\017.)Tj 0.059 Tw T* (1\))Tj /Span<>> BDC [( )-208( )]TJ EMC 1.37 0 Td [(\211\030\024\r\036\027\034 )0.6(\026\035\034\002\031\n\017\027\026 )0.5(\027\026)]TJ /Span<>> BDC ( )Tj EMC 9.628 0 Td [(\n\024\n\036\027\021 )0.5(\027\026\004\026\035\026 )0.6(\020\024\030\n\024\027\026\035\034)]TJ 0 Tw (-)Tj 0.324 Tw -9.628 -1.218 Td (\027\024\005 \021\036\030\026\023\017\017 \002\t\035 \f\021\026\021\017\f\ \021\017\004\036\f\022\017 \027\026\004\017\n\024 \027\017\032\036 )Tj -0.055 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \020\024\030\n\024\027\026\035\034\027\024\005 \ \030\036\017\f\021\036\027\021\027\024\f\021\017, \r)Tj /Span<>> BDC ( )Tj EMC (\f\030\036\007\027\036\n, )Tj ET 0 0 0 0 k /GS0 gs 70.866 100.996 221.103 153.071 re f /PlacedPDF /MC0 BDC 0 0 0 1 K 0.75 w 1 J q 1 0 0 1 74.4582 220.0169 cm 0 0 m 81.624 0 l 81.624 31.209 l 0 31.209 l h S Q BT 0 0 0 1 k /T1_4 1 Tf 0 Tw 7.6823 0 0 7.6823 79.8765 241.3606 Tm (\037)Tj -0.003 Tc 0.003 Tw 0.54 0 Td (\036\035)Tj 0 Tc 0 Tw (\034)Tj 1.276 0 Td (\033\032)Tj (\031)Tj 1.247 0 Td (\030)Tj 0.46 0 Td (\027)Tj 0.521 0 Td (\026)Tj (\035)Tj 0.96 0 Td (\031)Tj 0.514 0 Td (\033\032)Tj (\036)Tj 1.167 0 Td (\025\030\025\035\027)Tj -3.975 -2.16 Td (\024\032)Tj (\023)Tj 1.317 0 Td (\032\022\021\020\021)Tj ET q 1 0 0 1 77.8192 158.9749 cm 0 0 m 70.581 0 l 70.581 32.778 l 0 32.778 l h S Q BT /T1_4 1 Tf 7.6823 0 0 7.6823 85.1772 181.8997 Tm (\017\033)Tj (\036)Tj 1.533 0 Td (\016)Tj (\035)Tj 0.94 0 Td (\032)Tj (\036)Tj 0.667 0 Td (\r)Tj 0.464 0 Td (\f)Tj 0.003 Tc -0.003 Tw (\013\031\013\031)Tj 0 Tc 0 Tw (\034\030)Tj -1.364 -2.162 Td (\024\032)Tj (\023)Tj 1.317 0 Td (\032)Tj 0.463 0 Td (\n\t)Tj ET q 1 0 0 1 77.8192 103.5019 cm 0 0 m 70.645 0 l 70.645 30.473 l 0 30.473 l h S Q BT /T1_4 1 Tf 7.6823 0 0 7.6823 86.6367 124.1102 Tm (\037)Tj -0.003 Tc 0.003 Tw 0.54 0 Td (\036\035)Tj 0 Tc 0 Tw (\034)Tj 1.276 0 Td (\033\032\b\r)Tj 0.001 Tc -0.001 Tw (\016\007)Tj 0 Tc 0 Tw (\006)Tj 3.288 0 Td (\035)Tj 0.464 0 Td (\031)Tj 0.514 0 Td (\033)Tj -4.022 -2.16 Td (\024\032)Tj (\023)Tj 1.317 0 Td (\032)Tj 0.463 0 Td (\005\n)Tj ET q 1 0 0 1 176.5162 199.0169 cm 0 0 m 112.577 0 l 112.577 52.209 l 0 52.209 l h S Q BT /T1_4 1 Tf 7.6823 0 0 7.6823 180.8057 243.2669 Tm (\004\036\r\016\007\006\035\031\003\002\032)Tj 0 -1.2 TD (\025\001\r\001\032\031\035\032\036\033\033\025\b\035\025\036\025\b\007\025\ \032\r\f\013\025\035\f\013\201\215)Tj T* (\b\r\016\007\006\035\031\013\201\032\013\016\013\032\201\b\016\201\007\025\ \036\201\032)Tj T* (\026\217\016\013\r\030\025\030\215\013)Tj 0 -1.783 TD (\032\032\032\032\032\032\032\032\032\032\024\032\023\032\220\235\t\t\032\ \240\013\036\r\016\007\006\035\031\003\255\032)Tj ET q 1 0 0 1 176.5162 122.5929 cm 0 0 m 111.626 0 l 111.626 67.923 l 0 67.923 l h S Q BT /T1_4 1 Tf 7.6823 0 0 7.6823 181.417 178.7864 Tm (\004\036\r\016\007\006\035\031\033\032\200\033\036\016\035\032\200\f\033\ \006\025\035\031\013\201\032)Tj 0 -1.2 TD (\200\033\016\031\033\034\033\032\025\035\r\036\025\030\202)Tj T* (\203\032\204\013\036\025\035\215\030\025\013\006\035\036\r\013\027\032\033\ \217\205\033\f\032\206\032\005)Tj T* (\203\032\207\035\032\036\033\033\025\b\035\025\036\025\b\007\025\032\r\f\ \013\025\035\f\013\201\215\032)Tj T* (\b\r\016\007\006\035\031\013\201\032\206\032\210\210)Tj 0 -1.783 TD (\032\032\032\032\032\032\032\032\032\032\024\032\023\032\210\211\032\240\ \013\036\r\016\007\006\035\031\003\255\032\032\032)Tj ET 115.59 196.329 -0.641 23.687 re 115.59 220.017 m 117.19 196.97 m 115.27 193.129 l 113.349 196.97 l h f 114.181 137.176 -0.64 22.406 re 114.181 159.582 m 115.782 137.816 m 113.861 133.975 l 111.941 137.816 l h f q 1 0 0 1 156.1396 238.1912 cm 0 0 m 16.665 -4.051 l 16.544 -4.685 l -0.115 -0.627 l h 16.339 -2.361 m 19.751 -4.966 l 15.622 -6.138 l h f Q q 1 0 0 1 148.5469 176.4134 cm 0 0 m 24.694 -13.816 l 24.394 -14.386 l -0.294 -0.563 l h 24.868 -12.107 m 27.377 -15.589 l 23.081 -15.506 l h f Q EMC BT 1 0.68 0 0.12 k /T1_2 1 Tf 9 0 0 9 70.8661 90.1959 Tm (\022\t\217\210\b\002\220 1.)Tj 0 0 0 1 k /GS1 gs /T1_1 1 Tf ( \213\023\n\013-\t\004\031\003\026 \033\n\025\t\013\026 \023\025\024\031\ \032\026\024\205\032\020)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0 -1.2 TD [(F)-16(igure 1)47.1(.)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf ( Scheme of literature searching)Tj 1 0.68 0 0.12 k /GS0 gs /T1_5 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\214)10(\211\036\033 \035\030\032\t\033)30(\b)42(\032)-21(\240\033\233)]TJ 57.136 0 Td (REVIEW)Tj -57.136 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 23, \023\0221)69(, 202)69(4)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 23, \023\0221)69(, 202)69(4)]TJ /T1_6 1 Tf 25 0 0 25 20.9152 56.0378 Tm (174)Tj ET endstream endobj 278 0 obj <> endobj 282 0 obj <>stream 2024-01-18T00:32:15+06:00 Adobe Illustrator CS6 (Windows) 2024-01-18T00:38:08+05:00 2024-01-18T00:38:08+05:00 Adobe PDF library 10.01 application/pdf Ayrat Mingazov 18_00 1 False False 78.000062 53.999977 Millimeters Coloproctology-Regular Coloproctology Regular Open Type Version 1.000;PS 001.001;hotconv 1.0.38 False CPL_Regular.otf Black Default Swatch Group 0 K=100 GRAY PROCESS 255 Document xmp.did:604B561D6FB5EE1194C1B9D66733FF64 uuid:6f88a554-c855-4598-b83d-dd85823bd703 xmp.did:604B561D6FB5EE1194C1B9D66733FF64 proof:pdf saved xmp.iid:604B561D6FB5EE1194C1B9D66733FF64 2024-01-18T00:32:13+05:00 Adobe Illustrator CS6 (Windows) / endstream endobj 277 0 obj <> endobj 283 0 obj <> endobj 284 0 obj <> endobj 285 0 obj <>stream HdU TWc > Gu&"OV*!Gd&" b@D-(b-EjִV{U^{N{ss0bu$M7LT;W2 r!,L(fQ{bB+ ~1cK`h0e T8 @=hc8, 7326v0D͖V$x{b%EJJ{X Hp1̔({l`/Sh$F,*,^5e"ɠ:<ɼCgL׭Лkv^-M[ M|dHәM4nޔ=8W|7gs9!t}Ao4MïgD,\=^7[fHb0Fb x? D`S j(Nl6 +zG#X4Y|"M5>ǟ*AK9cd(bMO jjc/Kwp5!!P"W go2ܠf)Miw&J.&izb]qf9^v%,s;VCy0X~Dc5<^-?h8=U]œN8 NP>Q_v-E14Enۥh'eyAԔJkL M/` y54KIa##,(8Ov-A+P88Vñb&nv[, 0c"ǻYVSas9P0K-<q<٭Wv;c!UZ um܋V!;`hnkkmm#T>Ňu/7*( *}))(r; P(a6p`]B"|) q=8ZFi9=FvSsy*HH|,0v;E)yw r:v>\ .IQ^e$҉'->5viʲy[G̹h{i ʼn?"$$I 'ROH_6N%ha0Wr,i*N7RY8% .V ]^3LD0y|j׺<^2PP.;Kne^uUVVVVA{[>61zJ(֡vlmt~{#3 O9Wlɽ?'e$J}~E9zP{oPEQ׬EYI6|ٽ4WL,[]Q;w!6m6'jyqXE껞IM'>mêDQ Y&,uC@@q3C;(GQlO ˻=a~ niZ2qcrD܌$n>VҵCDOG>D_C(xsx}OU/>9~};EuSKW743>sp~b(W>a~Wӻ*\T]60",6MELF2f뒌tcjjgmbn$Z}AdBNBǽWwfB+ׯ\DŽm'i%% ҸF.ajqfgJItpQǁ&dҥpA&d"a"FRoFB SnA 9T_ tD 4~m!Hl3Dϲ |N`&._Ρ(0`|_Hj|זFMߎmFg7tu0źj?mĴϙ  y`jGqqFڒD>o뫝?y dJ"Ljlq7C5R +j,*)gHȦ~$Je]Y"}X׍UGf*1ʦ OaN?bCm%V"rePr]!aB:^78pV^5ٓ-*FSc]iӟ2;6Ua6 WE4MxTy`koMh݇K [bw<ol6~EҨW}"+sՙz9]Qv|ǛM"EG2i>2 w"Ip58 ۱.\ jIE1sjn\^2,s R"Gݡbm>`ܿ^1DA]'r T C~ji;~m'czg~^df~ : '/38XPP2>jˢGn(eIGbx4qܯbE$%M\3>Z`. >l#WHM.&ֻVқ6뫁^(TȉRv~A=Q8!aE]RESGٌrl3ȄeTmL$ 8cҡY5zCQjv nժr͵ϫ7\ wt d B7;߿ _qƢIgn͏ݣ2kl4*A$ts{:>.jl9D( (H5U|뺒<Q8|_à^簊0Q`\xJm0IXN5i!'.\cZ+'K D/~uc6{oAkWnWB֫y&9rsR©8dQ5Utr(}5(\m('kD 'FRl{j!B8Q?pnE1;F |5VHsY+q<<\@^Ϝ#} KV۬xd&5"G:E j`O aK5>|ƿ%qcD>ozg|o}Q~ƣO᠔z}:@7@{5@MU7lWqXMOmEm!v6W'z7נ}tęh Cy ב  Xk| endstream endobj 275 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\034\002\016\201\220\n)-9.9(\026)10.9(\025\002\020 \001\016\f\007\013\202)10(\025\221\002\220\205\026\001\025\202)10.1(\025 \220\006\207\025\201\013 \026)11(\016\002\013\221\220\220 )]TJ 0 -1 TD [(\n)10(\025\002\026\220\n)10(\025\006)-9.9(\026)11(\016\002\025\220\201\013\024\220 \215\022\221\013\227\220\016\001\026)11.1(\025\r \006\022\026\205\217\016\007\025\203 \013\026)11(\013\n)10(\025\203 \205\222\r\016\001\001\025\202)10.1(\025 )]TJ T* [(\n)10(\025\007\220\026)11(\013 \(\006\220\006)-10(\026)11(\016\024\013\026\220\017\016\006\n\220\203 \025\f\222\025\002 \220\022\024\ \016\026)11.1(\013\013\001\013\007\220\222\))]TJ 35.009 2 Td [(Pr)31(edictor)20.1(s of adv)12(er)20(se outcomes of ster)20(oids in patients with se)11(v)12(er)31(e )]TJ 3.699 -1 Td [(ulcer)21(ativ)12.1(e colitis \(s)10(y)10(stematic r)31(e)11(vie)11(w and meta-analy)10(ses\))]TJ ET 0 0 0 1 K 1 j 1 J [0 2.997]0 d /GS1 gs q 1 0 0 1 46.0167 706.8466 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 43.0197 706.8466 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q [0 2.997]0 d q 1 0 0 1 46.0167 669.6388 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 43.0197 669.6388 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q 0 j 0 J q 1 0 0 1 42.5197 615.5696 cm 0 0 m 453.543 0 l S Q BT 0 0 0 1 k /T1_1 1 Tf 0.01 Tc -0.01 Tw 8 0 0 8 42.5596 731.2159 Tm [(KEYW)22(ORDS:)]TJ /T1_2 1 Tf 0 Tc 0.023 Tw 4.948 0 Td [( ulcerativ)13.1(e colitis, acute sev)13(ere ulcerativ)13(e colitis, cor)-39.9(ticosteroid resistance, p)46(redictors of treatment failure, colectom)11(y)]TJ /T1_1 1 Tf 0.01 Tc 0.018 Tw -4.948 -1.909 Td [(C)19(ONFL)-33(ICT)5( OF)5( INTE)25(REST)62(:)]TJ /T1_2 1 Tf 0 Tc 0.023 Tw 9.871 0 Td [( The authors declare no conf)-22(lict of interest)]TJ /T1_1 1 Tf 0.037 Tc 0.033 Tw -9.871 -2.617 Td [(F)3.2(O)-4.6(R)8.7( C)-17.5(I)-15.5(T)45.4(A)37.5(T)-24.5(I)-1.3(ON:)]TJ /T1_3 1 Tf 0.023 Tc 0.042 Tw 6.477 0 Td [( M)-9.8(i)-3.2(n)-11.9(g)-8.1(a)-27.5(z)-11.2(o)-10.3(v)]TJ /Span<>> BDC ( )Tj EMC [(A)-23(.F)68.2(.)-23.5(, S)-12.1(u)-21.9(s)-8.8(h)-8.6(k)-3.7(o)-10.3(v)]TJ /Span<>> BDC ( )Tj EMC [(O)11.4(.)-9.8(I)-10.3(.)-23.5(, K)-30.4(a)-11.4(l)-37.8(a)-7.6(n)-11.9(o)-10.3(v)]TJ /Span<>> BDC ( )Tj EMC [(B)3.3(.R)-21.4(.)-23.5(, B)-16.4(a)-10.2(r)-30.8(a)-7.6(n)-11.9(o)-10.3(v)-28.4(a)]TJ /Span<>> BDC ( )Tj EMC [(T)52.5(.)-23.9(A)-23(.)-23.5(, A)-7.9(c)-10.2(h)-8.6(k)-24.2(a)-26.6(s)-19.1(o)-10.3(v)]TJ /Span<>> BDC ( )Tj EMC [(S)-9.6(.)-9.8(I)-10.3(. P)-18.6(r)-19.1(e)-21(d)-15.8(i)-5(c)-41.5(t)-21.9(o)-11.8(r)-30.3(s o)-12.1(f a)-13(d)-17.7(v)-18.7(e)-12.1(r)-30.3(s)-22.9(e o)-13.3(u)-16.3(t)-22.4(c)-6.5(o)-9.2(m)-16.6(e)-22.8(s o)-12.1(f s)-29.3(t)-24.7(e)-12.1(r)-15.8(o)-12.5(i)-8.8(d)-24.7(s)23( )]TJ 0.027 Tw -6.482 -1.2 Td [(i)-3.2(n)]TJ /Span<>> BDC ( )Tj EMC [(p)-20(a)-18.2(t)-46.2(i)-11(e)-11.5(n)-17.3(t)-48.9(s w)-45.7(i)-15.8(t)-26.1(h s)-22.9(e)-15.8(v)-18.7(e)-12.1(r)-19.1(e u)-8.4(l)-21.9(c)-9.7(e)-12.1(r)-30.8(a)-18.2(t)-46.2(i)-14.5(v)-18.6(e c)-6.5(o)-15.6(l)-16.7(i)-15.8(t)-46.2(i)-7.3(s \()28.9(s)-30.8(y)-28.8(s)-29.3(t)-24.7(e)-11.5(m)-8.3(a)-18.2(t)-46.2(i)-5(c r)-19(e)-15.8(v)-51.8(i)-11(e)-12.5(w a)-7.6(n)-14.5(d m)-16.5(e)-22.3(t)-36.8(a)-19.6(-)-13.1(a)-7.6(n)-7.8(a)-11.4(l)-8.3(y)-28.9(s)-22.9(e)-22.8(s)41.5(\))10.4(. )]TJ /T1_2 1 Tf 0.033 Tc -0.033 Tw [(K)13.9(ol)3.6(op)2.3(r)3.2(o)3.4(k)-19.2(t)2.2(ol)3.5(o)-3.2(g)-13.2(i)6.7(a)5.8(.)]TJ /T1_3 1 Tf 0.013 Tc 0.037 Tw 42.735 0 Td [( 2)-18.9(0)-13.8(2)-1.2(4;2)-20.3(3)-4(\()27.7(1)34.3(\))4.5(:)11(1)14.2(72\226)40.8(1)-12.4(8)-33.4(0)-3.5(.)-10.3( \()-10.9(i)-13.2(n)-10.3( R)-16.5(u)-31.9(s)-32.3(s)-25.5(.)33.2(\).)13.1( )]TJ -0.032 Tc 0.032 Tw -42.735 -1.2 Td [(h)-72.2(t)-104.4(t)-84.4(p)-73.7(s)-62.9(:)-53.1(/)29.7(/)-18.6(d)-66.1(o)-67.5(i)-55.2(.)-52.3(o)-66.8(r)-71.7(g)-77.8(/)-43.7(1)-41(0)-48.5(.)-60.6(3)-47.1(3)-70.9(8)-53.7(7)-50.4(8)-55(/)-47.1(2)-63.9(0)-45.7(7)-56.9(3)-68.3(-)-13.8(7)-44.3(5)-54.6(5)-63.9(6)-81.7(-)-45.2(2)-63.9(0)-58.8(2)-46.2(4)-83.5(-)-45.3(2)-65.3(3)-68.3(-1)-28.1(-1)-30.8(7)-44.7(2)-42.9(-1)-57.4(8)-78.4(0)]TJ /T1_1 1 Tf 0.01 Tc 0.061 Tw 0.005 -2.617 Td [(\026\020\021\033\030)5( \020\036\017)5( \013\033\021\033\013\023\030\037\023:)]TJ /T1_2 1 Tf 0 Tc 0.066 Tw 10.662 0 Td [( \240\025\021\202\026\016\n\027 \201\017\032\026\024 \225\026\021\025\023\ \031\027\025\006, )0.5(\225\210\213\214 \253\217\026\203\025\n\021\026\023\022\021\020\017 )0.5(\003\031\030\025\203\025\021\t\013\025\017 \025\t\t\023\031\030\n\027\026\ \024\031\023\022\t\013\025\017 )0.5(\203\031\021\024\032 \013\n\023\n\033\032\n\013\024\n\023\n\202\025\025 \ )]TJ 0.023 Tw -10.667 -1.2 Td (\025\003\031\021\025 \201.\217.)Tj /Span<>> BDC ( )Tj EMC (\212\020\204\025\004\273 \240\025\021\016\030\032\026\027\026 \212\n\t\t\ \025\025, \205\023.)Tj /Span<>> BDC ( )Tj EMC (\207\026\023\002\003\026 \201\030\025\023\002, \030.)Tj /Span<>> BDC ( )Tj EMC (2, \240\n\t\013\027\026, 123423, \024\031\023.:)Tj /Span<>> BDC ( )Tj EMC (+7 \(927\) 695-17-52; e-mail: ajr.mingazof@gmail.com)Tj /T1_1 1 Tf 0.01 Tc 0 Tw 0.005 -1.2 Td [(ADDRESS)5( F)13(OR)5( C)19(ORRESPONDEN)23(CE:)]TJ /T1_2 1 Tf 0 Tc 0.005 Tw 14.015 0 Td [( Ming)12.1(azov Airat F)15(anilevich, Ryzhikh N)18(ational Medical R)21(esearch Center of Colop)46.1(roctology)42.1(, Salyama Adilya st., 2, )]TJ 0.023 Tw -14.02 -1.2 Td [(Moscow)52(, 123423, phone number:)]TJ /Span<>> BDC ( )Tj EMC [(+7 \(927\) 695-17-52; e-mail: a)10(jr)51.1(.ming)12(azof@gmail.com)]TJ 0 Tw 0 -2.792 TD (\200\026\024\026 \033\n\t\024\205\033\023\031\021\025\002)Tj /Span<>> BDC ( )Tj EMC (\227 09.11.2023)Tj /Span<>> BDC ( )Tj EMC 19.488 0 Td (\n\t\023\031 \030\n\032\026\005\n\024\013\025)Tj /Span<>> BDC ( )Tj EMC (\227 19.12.2023)Tj /Span<>> BDC ( )Tj EMC 18.78 0 Td (\032\025\021\002\024\n \013)Tj /Span<>> BDC ( )Tj EMC (\033\205\005\023\025\013\026\203\025\025)Tj /Span<>> BDC ( )Tj EMC (\227 12.02.2024)Tj ( )Tj -38.268 -1.375 Td (Received)Tj /Span<>> BDC ( )Tj EMC (\227 09.11.2023)Tj /Span<>> BDC ( )Tj EMC 19.488 0 Td (Revised)Tj /Span<>> BDC ( )Tj EMC (\227 19.12.2023)Tj /Span<>> BDC ( )Tj EMC 18.78 0 Td (Accepted for publication)Tj /Span<>> BDC ( )Tj EMC (\227 12.02.2024)Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 42.5896 554.3379 Tm (\023\023\034\226\034\022\031\034)Tj 0 0 0 1 k /GS1 gs /T1_3 1 Tf 0 Tc 0.219 Tw 10 0 0 10 42.5197 529.9819 Tm (\247\r\036\027\027\t\005 \022\024\035\017\021 \(\247\025\))Tj /Span<>> BDC ( )Tj EMC (\227 \b\030\024\027\017\004\036\f\022\024\036 \026\002\024\035\036\r\026\ \027\017\036 )Tj 0.208 Tw 0 -1.218 TD (\021\024\035\f\021\024\005 \022\017\001\022\017, \b\026\030\026\022\021\036\ \030\017\031\033\013\036\036\f\016 \017\n\n\031\027\027\t\n \r\024\f)Tj 0 Tw (-)Tj -0.009 Tw T* (\023\026\035\036\027\017\036\n \036\036 \f\035\017\017\f\021\024\005 \024\ \002\024\035\024\004\022\017 [1]. \215\030\017)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\n \r)Tj /Span<>> BDC ( )Tj EMC (\030\026)Tj 0 Tw (-)Tj 0.083 Tw T* (\r\017\021\t\b \f\021\030\026\027\026\b \026\235\017\022\f\017\030\024\r\ \026\027 \f\021\026\002\017\035\034\027\t\005 \030\024\f\021 \023\024\022\ \026)Tj 0 Tw (-)Tj T* (\026\021\036\035\036\005 \026\002\024\035\036\r\026\036\n\024\f\021\017\ \017)Tj /Span<>> BDC ( )Tj EMC (\030\026\f\023\030\024\f\021\030\026\027\036\027\027\024\f\021\017 [2].)Tj 0.17 Tw T* (\221\021\024\017\021 \024\002\030\026\021\017\021\034 \r\027\017\n\026\027\ \017\036, \004\021\024 \027\036 \n\036\027\036\036, \004\036\n \r)Tj /Span<>> BDC ( )Tj EMC (30% )Tj 0.041 Tw T* (\f\035\031\004\026\036\r \007\036\002\033\021\026 \026\002\024\035\036\r\ \026\027\017\016 \r\024\027\017\022\026\036\021 \021\016\032\036\035\026\ \016 \026\021\026)Tj 0 Tw (-)Tj 0.105 Tw T* (\022\026 \247\025 [2,3]. \215\030\017)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\n \r)Tj /Span<>> BDC ( )Tj EMC (\021\036\004\036\027\017\036 \023\036\030\r\024\020\024 \020\024\007\026\ \023\024\f\035\036 )Tj 0.001 Tw T* (\n\026\027\017\235\036\f\021\026\006\017\017 \002\024\035\036\027\017 \007\ \024)Tj /Span<>> BDC ( )Tj EMC (40% \023\026\006\017\036\027\021\024\r \n\024\020\031\021 \002\t\021\034\ )Tj 0.097 Tw T* [(\023\024\007\r\036\030\020\027\031\021\t )0.6(\f\017\f\021\036\n\027\024\005 )0.5(\021\036\030\026\023\017\017 )0.5(\022\024\030\021\017\022\024\f\021\036\030\024\017\007\026\n\017 )]TJ 0.116 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\006\036\035\034\033 \017\027\007\031\022\006\017\017 \030\036\n\017\f\f\ \017\017 [3]. \215\036\030\r\017\004\027\026\016 \220\235\235\036\022)Tj 0 Tw (-)Tj 0.305 Tw T* [(\021\017\r\027\024\f\021\034 \035\036\004\036\027\017\016 )0.5(\022\024\030\021\017\022\024\f\021\036\030\024\017\007\026\n\017 \031)]TJ /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r )Tj 0.038 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\021\016\032\036\035\t\n \247\025 \027\036 \023\030\036\r\t\001\026\036\021\ 70%, \026)Tj /Span<>> BDC ( )Tj EMC (\024\022\024\035\024 40% \023\026\006\017)Tj 0 Tw (-)Tj 0.143 Tw T* (\036\027\021\024\r \f\021\026\035\022\017\r\026\033\021\f\016 \f)Tj /Span<>> BDC ( )Tj EMC (\027\036\002\035\026\020\024\023\030\017\016\021\027\t\n \017\f\b\024\007\ \024\n)Tj /Span<>> BDC ( )Tj EMC (\227 )Tj 0.531 Tw T* (\027\036\220\235\235\036\022\021\017\r\027\024\f\021\034\033 \020\024\030\ \n\024\027\026\035\034\027\024\005 \021\036\030\026\023\017\017 \017)Tj /Span<>> BDC ( )Tj EMC (\027\036)Tj 0 Tw (-)Tj 0.287 Tw T* (\024\002\b\024\007\017\n\024\f\021\034\033 \023\030\024\r\036\007\036\027\ \017\016 \253\021\036\030\026\023\017\017 \017\035\017 \b\017\030\031\030\ \020\017\017 )Tj -0.027 Tw T* (\f\023\026\f\036\027\017\016\273 [4,5]. \215\030\017)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\n \f\030\036\007\017 \023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\021\016\032\036\035\024\005 )Tj 0.266 Tw T* (\026\021\026\022\024\005 \247\025, \030\036\017\f\021\036\027\021\027\t\ \b \022)Tj /Span<>> BDC ( )Tj EMC (\020\024\030\n\024\027\026\035\034\027\024\005 \021\036\030\026\023\017\017\ , )Tj -0.02 Tw T* (\007\024)Tj /Span<>> BDC ( )Tj EMC (40% \n\024\020\031\021 \002\t\021\034 \023\024\007\r\036\030\020\027\031\ \021\t \030\026\007\017\022\026\035\034\027\024\n\031 \b\017\030\031\030\ )Tj 0 Tw (-)Tj 0.071 Tw T* (\020\017\004\036\f\022\024\n\031 \035\036\004\036\027\017\033 [6]. \210\023\ \036\030\026\021\017\r\027\024\036 \r\n\036\001\026\021\036\035\034\f\021\ \r\024 )Tj 0.059 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\005 \f\017\021\031\026\006\017\017, \r)Tj /Span<>> BDC ( )Tj EMC (\f\r\024\033 \024\004\036\030\036\007\034, \f\024\023\030\016\032\036\027\ \024 \f)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\036\036 )Tj 0.305 Tw T* (\004\036\n 60% \030\017\f\022\024\n \023\024\f\035\036\024\023\036\030\026\ \006\017\024\027\027\t\b \024\f\035\024\032\027\036\027\017\005, )Tj 0.011 Tw T* (\004\021\024, \r\036\030\024\016\021\027\024, \024\002\031\f\035\024\r\035\ \036\027\024 \026\021\016\020\017\r\026\027\017\036\n \020\024\030\n\024\ \027\026\035\034)Tj 0 Tw (-)Tj 0.06 Tw T* [(\027\024\005 )0.5(\021\036\030\026\023\017\017 )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC 6.273 0 Td [(\023\030\024\020\030\036\f\f\017\030\024\r\026\027\017\036\n )0.6(\017\n\036\033\013\017\b\f\016 )0.6(\n\036\021\026)]TJ 0 Tw (-)Tj -6.273 -1.218 Td (\002\024\035\017\004\036\f\022\017\b \027\026\030\031\001\036\027\017\005\ [7].)Tj 0.313 Tw T* [(\200 \021\036\004\036\027\017\036 )0.5(\007\035\017\021\036\035\034\027\024\020\024 )0.5(\r\030\036\n\036\027\017 \r)]TJ /Span<>> BDC ( )Tj EMC 15.669 0 Td [(\035\017\021\036\030\026\021\031\030\036 )0.5(\017)]TJ 0 Tw (-)Tj 0.283 Tw -15.669 -1.218 Td (\031\004\026\033\021\f\016 \030\026\035\017\004\027\t\036 \023\030\036\007\ \017\022\021\024\030\t, \023\024\021\036\027\006\017\026\035\034\027\024\ \023\024)Tj 0 Tw (-)Tj 0.364 Tw T* (\r\024\035\016\033\013\017\036 \023\030\024\020\027\024\017\030\024\r\026\ \021\034 \027\036\220\235\235\036\022\021\017\r\027\024\f\021\034 \020\024\ \030)Tj 0 Tw (-)Tj 0.176 Tw T* (\n\024\027\026\035\034\027\024\005 \021\036\030\026\023\017\017. \025)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\017\n \235\026\022\021\024\030\026\n \024\021\027\024\f\016\ \021 \022\026\022 )Tj 0.099 Tw T* (\026\027\026\n\027\036\f\021\017\004\036\f\022\017\036 \007\026\027\027\t\ \036, \035\026\002\024\030\026\021\024\030\027\t\036 \023\024\022\026\026\ \021\036\035\017, )Tj 0.428 Tw T* (\024\021\030\026\032\026\033\013\017\036 \r\t\030\026\032\036\027\027\024\ \f\021\034 \r\024\f\023\026\035\017\021\036\035\034\027\024\020\024 \023\ \030\024)Tj 0 Tw (-)Tj -0.042 Tw T* (\006\036\f\f\026, \021\026\022 \017)Tj /Span<>> BDC ( )Tj EMC (\220\027\007\024\f\022\024\023\017\004\036\f\022\017\036 \023\030\017\027\ \026\022\017, \024\006\036\027\017\r\026\036\n\t\036 )Tj 0 Tw T* (\023\030\017)Tj /Span<>> BDC ( )Tj EMC (\022\024\035\024\027\024\f\022\024\023\017\017 \023\036\030\036\007 \017\ \027\017\006\017\026\006\017\036\005 \021\036\030\026\023\017\017 \022\024\ \030\021\017)Tj (-)Tj 0.274 Tw T* (\022\024\f\021\036\030\024\017\007\026\n\017. \230\026\022\017\n \024\002\ \030\026\024\n, \006\036\035\034\033 \023\030\024\r\036\007\036\027\027\ \024)Tj 0 Tw (-)Tj 0.153 Tw T* (\020\024 \f\017\f\021\036\n\026\021\017\004\036\f\022\024\020\024 \024\002\ \024\030\026 \017)Tj /Span<>> BDC ( )Tj EMC (\n\036\021\026\026\027\026\035\017\026 \016\r\017\035\024\f\034 )Tj 0.229 Tw T* (\024\002\024\002\013\036\027\017\036 \030\036\031\035\034\021\026\021\024\ \r \035\036\004\036\027\017\016 \017)Tj /Span<>> BDC ( )Tj EMC (\r\t\016\r\035\036\027\017\036 \023\030\036)Tj 0 Tw (-)Tj 0.071 Tw T* (\007\017\022\021\024\030\024\r \020\024\030\n\024\027\026\035\034\027\024\ \005 \030\036\017\f\021\036\027\021\027\024\f\021\017 \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r )Tj 0 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\021\016\032\036\035\t\n \247\025 \023\024)Tj /Span<>> BDC ( )Tj EMC (\007\026\027\027\t\n \035\017\021\036\030\026\021\031\030\t.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 0.01 Tc 0.018 Tw 14 0 0 14 275.0305 554.3379 Tm [(\240)21(\026)45(\024\034\033\031\026)-10(\r\232)5( \031)5(\016)-18.3(\240\034)-31(\024)35(\037\226\232)]TJ 0 0 0 1 k /GS1 gs /T1_3 1 Tf 0 Tc 0.436 Tw 10 0 0 10 274.9606 529.9819 Tm (\221\017\f\021\036\n\026\021\017\004\036\f\022\017\005 \024\002\024\030\ \017)Tj /Span<>> BDC ( )Tj EMC (\n\036\021\026\026\027\026\035\017 \r\t\023\024\035\027\036\027\t )Tj 0.074 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\f\024\024\021\r\036\021\f\021\r\017\017 \f)Tj /Span<>> BDC ( )Tj EMC [(\030\036\022\024\n\036\027\007\026\006\017\016\n\017 PRISMA \(P)35(r)-24(efer)-23.9(r)-24(ed )]TJ 0.316 Tw T* [(R)13(epor)-22(t)-32(ing Items )0.5(for Sy)-13(stema)15.1(t)-32(ic R)13(ev)-16(iews )0.5(and Me)-12(t)15(a-)]TJ 0.141 Tw T* [(Anal)35(y)-13(ses [8]. \215\024\017\f\022 \035\017\021\036\030\026\021\031\030\t \023\030\ \024\017\r\024\007\017\035\f\016 \r)]TJ /Span<>> BDC ( )Tj EMC (\f\017)Tj 0 Tw (-)Tj 0.21 Tw T* [(\f\021\036\n\026\b P)20(ubMed \017)]TJ /Span<>> BDC ( )Tj EMC [(Go)-15.9(o)-16(gle S)-24(chol)-16(ar \f)]TJ /Span<>> BDC ( )Tj EMC (\017\f\023\024\035\034\024\r\026\027\017\036\n )Tj -0.004 Tw T* [(\022\035\033\004\036\r\t\b \f\035\024\r: \(\(\(ul)16(cer)-32.9(a)15(t)-32(i)-16(ve col)-31(i)-23.9(t)-32(is [MeSH T)40(er)-16(ms]\) OR )]TJ -0.046 Tw T* [(\(\231ul)16(cer)-33(a)15.1(t)-32(i)-16(ve )0.6(col)-31(i)-24(t)-32(is\232\) )0.6(A)51(ND )0.6(\(sever)-24(e\) )0.6(OR )0.5(\(\231a)-16.9(cute )0.6(sever)-24(e\232\)\) )]TJ -0.015 Tw T* [(A)51(ND \(\(outcomes\) OR \(colec)-16(t)17(omy\) OR \(sur)-32(ger)-23.9(y\) OR \(\231ad)]TJ 0 Tw (-)Tj 0.245 Tw T* [(ver)-10(se ef)-56(fec)-16(t\232\) OR \(\231tr)-23.9(ea)15(tment f)16(ail)35.1(ur)-24(e\232\) OR \(\231ster)-32(oid )]TJ 0.01 Tw T* [(r)-24(esist)15.1(ance\232\) OR \(r)-23.9(efr)-33(a)-17(c)-16(t)17(or)-23.9(y\)\) A)51(ND \(\(\231p)25(r)-23.9(edic)-16(t)-32(i)-16(ve v)-15(al)35(ue\232\) )]TJ 0.282 Tw T* [(OR \(p)25(r)-24(edic)-15.9(t)17(or)-10(s\) OR \(\231r)-37(isk f)16(a)-17(c)-16(t)17(or)-10(s\232\) OR \(biomar)-24(k)10(er)-10(s\) )]TJ 0.076 Tw T* (OR \(albumin\) OR \(\231C)Tj /Span<>> BDC ( )Tj EMC [(\227 r)-23.9(ea)-17(c)-16(t)-32(i)-16(ve p)25(r)-32(o)17(tein\232\) OR \(end)-16(os)]TJ 0 Tw (-)Tj 0.137 Tw T* [(copy\) OR \(hemo)-16(gl)30.1(obin\) OR \(l)-16(abor)-33(a)15(t)17(or)-24(y\) OR \(inde)-18(x\)\)\). )]TJ 0.057 Tw T* (\025\035\033\004\036\r\t\036 \f\035\024\r\026 \002\t\035\017 \024\021\024\ \002\030\026\027\t \027\026)Tj /Span<>> BDC ( )Tj EMC (\024\f\027\024\r\026\027\017\017 \023\030\036\007)Tj 0 Tw (-)Tj 0.313 Tw T* (\r\026\030\017\021\036\035\034\027\024\020\024 \026\027\026\035\017\026\ \035\017\021\036\030\026\021\031\030\t. \215\036\030\017\024\007 \023\024\ \017\f\022\026 )Tj 0 Tw T* (\f\024\f\021\026\r\017\035 10 \035\036\021 \(2012\2262022\).)Tj 0.389 Tw T* (\215\036\030\r\t\n \220\021\026\023\024\n \023\030\024\017\r\024\007\017\ \035\f\016 \f\022\030\017\027\017\027\020 \027\026\r\026\027\017\005 )Tj 0.134 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\030\036\033\n\036 \027\026\005\007\036\027\027\t\b \f\021\026\021\036\005\ \027\026)Tj /Span<>> BDC ( )Tj EMC (\f\024\024\021\r\036\021\f\021\r\017\036 \026\007\026\027)Tj 0 Tw (-)Tj 0.018 Tw T* (\027\024\005 \021\036\n\026\021\017\022\036 \017)Tj /Span<>> BDC ( )Tj EMC (\022\030\017\021\036\030\017\016\n \r\022\035\033\004\036\027\017\016 \r\ )Tj /Span<>> BDC ( )Tj EMC (\f\017\f\021\036\n\026\021\017\004\036)Tj 0 Tw (-)Tj T* (\f\022\017\005 \024\002\024\030:)Tj T* (1.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (\200\030\024\f\035\t\036 \023\026\006\017\036\027\021\t \f)Tj /Span<>> BDC ( )Tj EMC (\021\016\032\036\035\t\n \247\025;)Tj -1.296 -1.218 Td (2.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (\221\021\026\021\034\017 \f)Tj /Span<>> BDC ( )Tj EMC (\027\026\035\017\004\017\036\n \023\024\035\027\024\020\024 \021\036\022\ \f\021\026 \r)Tj /Span<>> BDC ( )Tj EMC (\007\024\f\021\031\023\036;)Tj 0.7 Tw -1.296 -1.218 Td (3.)Tj /Span<>> BDC [( )433( )]TJ EMC 1.296 0 Td (\210\002\f\036\030\r\026\006\017\024\027\027\t\036 \017\f\f\035\036\007\024\ \r\026\027\017\016, \027\026\023\030\026\r\035\036\027\027\t\036 )Tj 0.249 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC (\023\024\017\f\022 \023\030\036\007\017\022\021\024\030\024\r \027\036\220\ \235\235\036\022\021\017\r\027\024\f\021\017 \020\024\030\n\024)Tj 0 Tw (-)Tj T* (\027\026\035\034\027\024\005 \021\036\030\026\023\017\017 \023\026\006\017\ \036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\021\016\032\036\035\t\n \247\025.)Tj 0.246 Tw -1.296 -1.218 Td (\200 \f\035\031\004\026\036 \031\007\024\r\035\036\021\r\024\030\036\027\ \017\016 \022\030\017\021\036\030\017\016\n \023\030\024\017\r\024\007\017\ \035\f\016 )Tj 0.144 Tw T* (\026\027\026\035\017 \023\024\035\027\024\020\024 \021\036\022\f\021\026\ \024\021\024\002\030\026\027\027\t\b \f\021\026\021\036\005 \027\026)Tj /Span<>> BDC ( )Tj EMC (\024\021\f\031\021)Tj 0 Tw (-)Tj 0.293 Tw T* [(\f\021\r\017\036 \r\024\n\024\032\027\t\b \024\020\030\026\027\017\004\036\ \027\017\005. )0.5(\221\021\026\021\034\017 \024\021\002\017\030\026\035\017\f\034 )]TJ 0.19 Tw T* (\023\024)Tj /Span<>> BDC ( )Tj EMC (\027\026\035\017\004\017\033 \024\023\017\f\026\027\027\t\b \r)Tj /Span<>> BDC ( )Tj EMC (\023\024\035\027\024\005 \n\036\030\036 \030\036\031\035\034\021\026\021\ \024\r )Tj 0.16 Tw T* (\f\030\026\r\027\017\021\036\035\034\027\024\020\024 \017)Tj /Span<>> BDC ( )Tj EMC (\235\026\022\021\024\030\027\024\020\024 \026\027\026\035\017\026 \023\030\ \036\007\017\022\021\024\030\024\r )Tj 0.085 Tw T* [(\027\036\002\035\026\020\024\023\030\017\016\021\027\024\020\024 )0.5(\017\f\b\024\007\026 \021\036\030\026\023\017\017 \f)]TJ /Span<>> BDC ( )Tj EMC (\023\030\036\007\f\021\026\r\035\036\027\027\t)Tj 0 Tw (-)Tj 0.18 Tw T* (\n\017 \027\026\004\036\027\017\016\n\017 \022\024\035\017\004\036\f\021\ \r\036\027\027\t\b \023\036\030\036\n\036\027\027\t\b \017)Tj /Span<>> BDC ( )Tj EMC (\031\022\026)Tj 0 Tw (-)Tj 0.171 Tw T* (\026\027\017\036\n \n\036\030\t \006\036\027\021\030\026\035\034\027\024\ \005 \021\036\027\007\036\027\006\017\017 \017)Tj /Span<>> BDC ( )Tj EMC (\017\n\036\027\004\017\r\024)Tj 0 Tw (-)Tj 0.175 Tw T* (\f\021\017, \026)Tj /Span<>> BDC ( )Tj EMC 2.798 0 Td [(\021\026\022\032\036 \026\002\f\024\035\033\021\027\t\b )0.5(\006\017\235\030 )0.5(\007\035\016 \022\026\021\036\020\024\030\017\026\035\034\027\t\b )]TJ 0 Tw -2.798 -1.218 Td (\007\026\027\027\t\b.)Tj 0.364 Tw T* (\221\021\026\021\017\f\021\017\004\036\f\022\031\033 \024\002\030\026\002\ \024\021\022\031 \007\026\027\027\t\b \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\f\030\026\r\027\036\027\017\017 )Tj 0.148 Tw T* (\r\t\001\036\031\022\026\026\027\027\t\b \n\036\021\024\007\024\r \035\036\ \004\036\027\017\016 \r\t\023\024\035\027\016\035\017 \r)Tj /Span<>> BDC ( )Tj EMC (\023\030\024)Tj 0 Tw (-)Tj 0.37 Tw T* [(\020\030\026\n\n\036 R)13(ev)-16(iew Mana)-17(ger 5.3. \221\031\n\n\026\030\027\024\036 \027\026\004\036\027\017\036 \ )]TJ 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 0 Tw 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\214)10(\211\036\033 \035\030\032\t\033)30(\b)42(\032)-21(\240\033\233)]TJ 57.136 0 Td (REVIEW)Tj /T1_5 1 Tf 25 0 0 25 505.5395 56.0378 Tm (173)Tj ET endstream endobj 271 0 obj [286 0 R] endobj 272 0 obj <>stream q /GS0 gs /Fm0 Do Q 0 0 0 1 K 1 j 1 J [0 2.997]0 d /GS1 gs q 1 0 0 1 74.3631 363.4103 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 71.3661 363.4103 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q [0 2.997]0 d q 1 0 0 1 74.3631 326.2025 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 71.3661 326.2025 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q BT 0 0 0 1 k /T1_0 1 Tf 10 0 0 10 70.8661 724.8299 Tm (https://doi.org/10.33878/2073-7556-2024-23-1-172-180)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0.023 Tw 19 0 0 19 109.7787 695.3259 Tm [(\034\002\016\201\220\n)-9.9(\026)10.9(\025\002\020 \001\016\f\007\013\202)10(\025\221\002\220\205\026\001\025\202)10.1(\025 \220\006\207\025\201\013 \026)11(\016\002\013\221\220\220 )]TJ -0.637 -1.105 Td [(\n)10(\025\002\026\220\n)10(\025\006)-10(\026)11.1(\016\002\025\220\201\013\024\220 \215\022)-23.3(\221\013\227\220\016\001\026)11(\025\r \006\022)-23.3(\026\205\217\016\007\025\203 \013\026)11(\013\n)10(\025\203 )]TJ -1.41 -1.105 Td [(\205\222\r\016\001\001\025\202)10.1(\025 \n)10(\025\007\220\026)11(\013 \(\006\220\006)-10(\026)11(\016\024\013\026\220\017\016\006\n\220\203 \025\f\222\025\002 \220\022)-23.3(\024\016\026)11(\013\013\001\013\007\220\222\))]TJ 0 0 0 1 k /GS1 gs 0 Tw 14 0 0 14 70.8661 628.822 Tm [(\005\220\001\202)10(\013\222\025\r\022)-23.2(\b)-31(.\210.)]TJ 8.162 0 0 8.162 160.3148 633.484 Tm (1)Tj 0.023 Tw 14 0 0 14 164.9508 628.822 Tm [(, \021\215\n)10(\025\r\022)-23.2(\036.\030.)]TJ 0 Tw 8.162 0 0 8.162 249.5459 633.484 Tm (1)Tj 0.023 Tw 14 0 0 14 254.1819 628.822 Tm [(, \037)41(\013\007\013\001\025\r\022)-23.2(\214.\033)124(.)]TJ 0 Tw 8.162 0 0 8.162 334.8152 633.484 Tm (1)Tj 0.023 Tw 14 0 0 14 339.4511 628.822 Tm [(, \214\013\002\013\001\025\r\013\022)-23.2(\032.\b)-31(.)]TJ 0 Tw 8.162 0 0 8.162 431.34 633.484 Tm (1)Tj 14 0 0 14 435.976 628.822 Tm (, )Tj -26.079 -1.143 Td [(\b)20(\017\n\013\006\025\r\022)-23.2(\021.\030.)]TJ -0.069 Tc 0.069 Tw 8.162 0 0 8.162 148.4575 617.484 Tm [(1,)-69(2)]TJ 0 Tc 0 Tw 5.83 0 0 5.83 70.8661 598.4827 Tm (1)Tj 0.023 Tw 10 0 0 10 74.1775 595.1527 Tm [(\210\031\214)42(\240 \253\213\005\030\226 \n)10(\025\007\025\221\002\025\n)-9.9(\026)11(\025\007\025\202\220\220 \220\024\016\001\220 \b)-30.9(.\213.\022)-23.3(\033\020\217\220\207\273 \005\220\001\222\201\002\013\r\013 \033\025\006\ \006\220\220 \(\215\007.\022)-23.3(\021\013\007\205\024\013 \b)-20.9(\201\220\007\205, \201.\022)-23.3(2, \202)62.1(.\022)-23.3(\005\025\006\n\r\013, )]TJ -0.331 -1.2 Td [(1)125(23)58(423, \033\025\006\006\220\205\))]TJ 0 Tw ( )Tj 5.83 0 0 5.83 70.8661 574.4827 Tm (2)Tj 0.023 Tw 10 0 0 10 74.1775 571.1527 Tm [(\210\031\214)21(\036)20(\240 \255\034\036 \033)21(\005\b\213\034\036 \005\220\001\222\201\002\013\r\013 \033\025\006\006\220\ \220 \(\215\007.\022)-23.2(\214\013\002\002\220\n\013\201\001\013\205, \201.\022)-23.3(2/1)69(, \006)-10(\026\002)-31(.\022)-23.3(1)69(, \202)62(.\022)-23.2(\005\025\006\n\r\013, 1)125(2)23(5)23(99)35(3, \033\025\006\006\220\205\))]TJ /T1_0 1 Tf 0.195 Tw 9 0 0 9 119.0551 552.6488 Tm [(\037\036\035\034: \027\020\002\027\025\024\022 \033\032\031\030\025\013\024\ \n\032\020 )0.5(\202\n\032\003\n\021\026\023\022\021\n\017 )0.5(\032\031\016\025\t\024\031\021\024\021\n\t\024\025 )0.5(\205)]TJ /Span<>> BDC ( )Tj EMC (\033\026\203\025\031\021\024\n\027 \t)Tj /Span<>> BDC ( )Tj EMC (\024\002\204\031\023\n\017 \026\024\026\013\n\017 \002\016\027\031\021\021\ \n\202\n )Tj 0.023 Tw 0 -1.111 TD (\013\n\023\025\024\026 \(\243\222\).)Tj 0.004 Tw T* (\201\037\215\036\217\220\235 \215)Tj /Span<>> BDC ( )Tj EMC (\240\036\220\255\200\235: \033\032\n\027\031\030\031\021 \t\025\t\024\031\ \003\026\024\025\006\031\t\013\025\017 \n\005\016\n\032 \025)Tj /Span<>> BDC ( )Tj EMC (\003\031\024\026\026\021\026\023\025\016, \027\013\023\007\006\031\021\n\ 18 \n\005\t\031\032\027\026\203\025\n\021\021\020\004 \025\t\t\023\031)Tj 0 Tw (-)Tj 0.023 Tw T* (\030\n\027\026\021\025\017 \033\n)Tj /Span<>> BDC ( )Tj EMC (\024\025\033\205 \253\t\023\205\006\026\017-\013\n\021\024\032\n\023\022\ \273 \025)Tj /Span<>> BDC ( )Tj EMC (2545 \033\026\203\025\031\021\024\n\027 \t)Tj /Span<>> BDC ( )Tj EMC (\024\002\204\031\023\n\017 \026\024\026\013\n\017 \243\222.)Tj 0.175 Tw T* (\212\036\221\214\035\034\220\201\220\235: \030\n\023\002 \033\026\203\025\ \031\021\024\n\027, \205)Tj /Span<>> BDC ( )Tj EMC (\013\n\024\n\032\020\004 \024\031\032\026\033\025\002 \013\n\032\024\025\ \013\n\t\024\031\032\n\025\030\026\003\025 \n\013\026\016\026\023\026\t\022\ \r\f\f\031\013\024\025\027\021\n\017, \t\n\t\024\026)Tj 0 Tw (-)Tj 0.176 Tw 0 -1.111 TD (\027\025\023\026 69,5%, \026)Tj /Span<>> BDC ( )Tj EMC (\202\n\032\003\n\021\026\023\022\021\026\002 \032\031\016\025\t\024\031\021\ \n\t\024\022 \032\026\016\027\025\023\026\t\022 \027)Tj /Span<>> BDC ( )Tj EMC (30,5% \t\023\205\006\026\031\027. \220\n\024\026\023\022\021\n\031 \033\n\ \032\026\204\031\021\025\031 \t\023\025\016\025\t\024\n\017 )Tj 0.039 Tw 0 -1.111 TD [(\n\005\n\023\n\006\013\025 \024\n\023\t\024\n\017 )0.5(\013\025\001\013\025 \(\255\231)]TJ /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (1,5 95% \200\215: 1,1\2262\) \025)Tj /Span<>> BDC ( )Tj EMC (\r\021\030\n\t\013\n\033\025\006\031\t\013\026\002 \013\026\032\024\025\021\ \026 \033\n)Tj /Span<>> BDC ( )Tj EMC (\001\013\026\023\031 UCEIS)Tj /Span<>> BDC ( )Tj EMC (\247)Tj /Span<>> BDC ( )Tj EMC (7 \005\026\023\023\n\027 )Tj 0.168 Tw T* (\(\255\231)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (4,5; 95% \200\215: 3,2\2266,5\) \002\027\025\023\025\t\022 \033\032\031\030\ \025\013\024\n\032\026\003\025 \202\n\032\003\n\021\026\023\022\021\n\017\ \032\031\016\025\t\024\031\021\024\021\n\t\024\025. \214\032\n\027\031\021\ \022 \026\023\022\005\205\003\025\021\026 )Tj 0.063 Tw T* (\025)Tj /Span<>> BDC ( )Tj EMC (\207-\032\031\026\013\024\025\027\021\n\202\n \005\031\023\013\026 \033\031\ \032\031\030 \021\026\006\026\023\n\003 \025)Tj /Span<>> BDC ( )Tj EMC (\021\026 3 \t\205\024\013\025 \033\032\n\027\n\030\025\003\n\202\n \023\031\ \006\031\021\025\002 \013\n\032\024\025\013\n\t\024\031\032\n\025\030\026\ \003\025 \024\026\013\204\031 \t\024\026)Tj 0 Tw (-)Tj 0.087 Tw T* (\024\025\t\024\025\006\031\t\013\025 \016\021\026\006\025\003\n \013\n\032\ \032\031\t\033\n\021\030\025\032\n\027\026\023\025 \t)Tj /Span<>> BDC ( )Tj EMC (\032\026\016\027\025\024\025\031\003 \021\031\005\023\026\202\n\033\032\025\ \002\024\021\n\202\n \025\t\004\n\030\026 \023\031\006\031\021\025\002)Tj /Span<>> BDC ( )Tj EMC (\227 \202\n\032\003\n\021\026\023\022\021\n\017 )Tj 0.023 Tw T* (\032\031\016\025\t\024\031\021\024\021\n\t\024\025 \(p)Tj /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (0,00001\).)Tj 0.197 Tw T* (\221\201\222\035\223\224\036\217\215\036: \033\n)Tj /Span<>> BDC ( )Tj EMC [(\032\031\016\205\023\022\024\026\024\026\003 )0.5(\033\032\n\027\031\030\031\021\021\n\202\n )0.5(\003\031\024\026\026\021\026\023\025\016\026, )0.5(\033\032\031\030\025\013\024\n\032\026\003\025 \021\031\005\023\026\202\n\ \033\032\025\002\024\021\n\202\n \025\t\004\n\030\026)]TJ /Span<>> BDC ( )Tj EMC (\227 )Tj 0.307 Tw T* [(\202\n\032\003\n\021\026\023\022\021\n\017 )0.6(\032\031\016\025\t\024\031\021\024\021\n\t\024\025 )0.6(\002\027\023\002\023\025\t\022 )0.6(\024\n\024\026\023\022\021\n\031 )0.6(\033\n\032\026\204\031\021\025\031 )0.5(\t\023\025\016\025\t\024\n\017 )0.5(\n\005\n\023\n\006\013\025 )0.5(\024\n\023\t\024\n\017 \013\025\001\013\025, )]TJ 0.04 Tw T* (\026)Tj /Span<>> BDC ( )Tj EMC (\024\026\013\204\031 \r\021\030\n\t\013\n\033\025\006\031\t\013\026\002 \ \013\026\032\024\025\021\026 \033\n)Tj /Span<>> BDC ( )Tj EMC (\001\013\026\023\031 UCEIS)Tj /Span<>> BDC ( )Tj EMC (\247)Tj /Span<>> BDC ( )Tj EMC (7 \005\026\023\023\n\027. \220\026\013\204\031 \202\025\033\n\026\023\022\ \005\205\003\025\021\031\003\025\002 \025)Tj /Span<>> BDC ( )Tj EMC (\027\020\t\n\013\025\017 \205\032\n\027\031\021\022 )Tj 0.023 Tw 0 -1.111 TD (\207-\032\031\026\013\024\025\027\021\n\202\n \005\031\023\013\026 \026\t\ \t\n\203\025\025\032\n\027\026\021\020 \t)Tj /Span<>> BDC ( )Tj EMC (\032\026\016\027\025\024\025\031\003 \202\n\032\003\n\021\026\023\022\021\ \n\017 \032\031\016\025\t\024\031\021\024\021\n\t\024\025.)Tj /T1_2 1 Tf 0.01 Tc 0.278 Tw 8 0 0 8 70.9061 397.3795 Tm [(\037\036\035\034\033\032\031\033)5( \030\036\027\032\026:)]TJ /T1_0 1 Tf 0 Tc 0.283 Tw 8.753 0 Td ( \002\016\027\031\021\021\020\017 \013\n\023\025\024, \024\002\204\031\023\ \026\002 \026\024\026\013\026, \202\n\032\003\n\021\026\023\022\021\026\002\ \032\031\016\025\t\024\031\021\024\021\n\t\024\022, \033\032\031\030\025\ \013\024\n\032\020 \021\031\r\f\f\031\013\024\025\027\021\n\t\024\025 \024\ \031\032\026\033\025\025, )Tj 0 Tw -8.758 -1.2 Td (\013\n\023\r\013\024\n\003\025\002)Tj /T1_2 1 Tf 0.01 Tc 0.018 Tw 0.005 -1.909 Td [(\037\027\025\024\036\023\037\022)5( \023\025\022\033\021\033\030\027\032:)]TJ /T1_0 1 Tf 0 Tc 0.023 Tw 10.401 0 Td ( \026\027\024\n\032\020 \016\026\002\027\023\002\007\024 \n\005 \n\024\t\ \205\024\t\024\027\025\025 \013\n\021\f\023\025\013\024\026 \025\021\024\ \031\032\031\t\n\027)Tj /T1_2 1 Tf 0.033 Tc -0.026 Tw -10.401 -2.617 Td [(\020\036\017)4.7( \016\023\022\023\021\027\032\026\025\023\017:)]TJ /T1_3 1 Tf 0.023 Tc -0.021 Tw 9.146 0 Td ( \204\017\027\020\026\024\r)Tj /Span<>> BDC ( )Tj EMC (\202.\205., \221\031\001\022\024\r)Tj /Span<>> BDC ( )Tj EMC (\210.\222., \025\026\035\026\027\024\r)Tj /Span<>> BDC ( )Tj EMC (\207.\217., \207\026\030\026\027\024\r\026)Tj /Span<>> BDC ( )Tj EMC (\230.\202., \202\004\022\026\f\024\r)Tj /Span<>> BDC ( )Tj EMC [(\221.\222. \215\030\036\007\017\022\021\024\030\t \027\036\002\035\026\020\ \024\023\030\017\016\021\027\024\020\024 \017\f\b\024\007\026)23( )]TJ 0.005 Tc -0.035 Tw -9.151 -1.2 Td (\021\036\030\026\023\017\017 \022\024\030\021\017\022\024\f\021\036\030\024\ \017\007\026\n\017 \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\021\016\032\036\035\024\005 \026\021\026\022\024\005 \016\r\036\027\027\ \024\020\024 \022\024\035\017\021\026 \(\f\017\f\021\036\n\026\021\017\004\ \036\f\022\017\005 \024\002\024\030 \017)Tj /Span<>> BDC ( )Tj EMC (\n\036\021\026\026\027\026\035\017\). )Tj /T1_0 1 Tf -0.005 Tw (\222\n\023\n\033\032\n\013\024\n\023\n\202\025\002.)Tj /T1_3 1 Tf 0 Tc 0 Tw 56.693 0 Td ( )Tj 0.023 Tc 0.024 Tw -56.693 -1.2 Td (2024; \021.)Tj /Span<>> BDC ( )Tj EMC (23, \225)Tj /Span<>> BDC ( )Tj EMC (1, \f.)Tj /Span<>> BDC ( )Tj EMC (172\226180. https://doi.org/10.33878/2073-7556-2024-23-1-172-180)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0 Tc 0.023 Tw 18 0 0 18 91.6735 300.0332 Tm [(Pr)31(edictor)20.1(s of adv)12(er)20(se outcomes of ster)20(oids in patients with )]TJ -0.892 -1.167 Td [(se)11(v)12(er)31(e ulcer)21.1(ativ)12(e colitis \(s)10(y)10(stematic r)31(e)11(vie)11(w and meta-analy)10.1(ses\))]TJ 0 0 0 1 k /GS1 gs 0 Tw 14 0 0 14 70.8661 254.5293 Tm [(Air)21(at\022)-23.2(F)94(.\022)-23.3(Minga)20(z)10(ov)]TJ 8.162 0 0 8.162 170.665 259.1913 Tm (1)Tj 0.023 Tw 14 0 0 14 175.301 254.5293 Tm [(, Oleg\022)-23.2(I.\022)-23.3(Sushk)11(ov)]TJ 0 Tw 8.162 0 0 8.162 271.6458 259.1913 Tm (1)Tj 0.023 Tw 14 0 0 14 276.2818 254.5293 Tm [(, Bulat\022)-23.2(R.\022)-23.3(K)41(alanov)]TJ 0 Tw 8.162 0 0 8.162 376.6447 259.1913 Tm (1)Tj 0.023 Tw 14 0 0 14 381.2806 254.5293 Tm [(, T)40(atiana\022)-23.2(A)-31(.\022)-23.3(Bar)21(anov)10(a)]TJ 0 Tw 8.162 0 0 8.162 504.9671 259.1913 Tm (1)Tj 14 0 0 14 509.603 254.5293 Tm (, )Tj -31.338 -1.143 Td [(Ser)31(gey\022)-23.2(I.\022)-23.3(Achkasov)]TJ -0.069 Tc 0.069 Tw 8.162 0 0 8.162 178.5469 243.1913 Tm [(1,)-69(2)]TJ 0 Tc 0 Tw 5.83 0 0 5.83 70.8661 224.19 Tm (1)Tj 0.023 Tw 10 0 0 10 74.1775 220.86 Tm [(R)20(y)21(zhikh National Medical Resear)31(ch Center of Colopr)20.1(octology \(Saly)21(ama Adily)21(a\022)-23.3(st., 2, Moscow)22(, 1)125(23)58(423, Russia\))]TJ 0 Tw ( )Tj 5.83 0 0 5.83 70.8661 212.19 Tm (2)Tj 0.023 Tw 10 0 0 10 74.1775 208.86 Tm [(Russian Medical Academ)21.1(y of Continuous Pr)20(ofessional Education \(Barrikadnay)21.1(a\022)-23.3(st., 2/1)69(, Moscow)22(, 1)125(2)23(5)23(99)35(3, )]TJ 0 Tw -0.331 -1.2 Td (Russia\))Tj /T1_0 1 Tf 0.023 Tw 9 0 0 9 119.0551 178.3561 Tm [(AIM: to identify p)46(redictors of steroid resistance among patients with sev)13(ere ulcerativ)13(e colitis \(UC\).)]TJ 0.022 Tw 0 -1.111 TD [(P)45(A)45(TIENT)-9.9(S A)53(ND METHODS: the systematic revie)10.1(w and meta-analysis w)12(ere done, 18 obser)-41.9(v)16(ational case-control studies )]TJ 0.023 Tw T* [(and 2545 patients with sev)13(ere UC w)12(ere included.)]TJ 0.056 Tw T* [(RESUL)30(T)-10(S: )0.6(the )0.6(rate )0.6(of )0.6(patients )0.6(with )0.6(ef)-40(fectiv)13(e )0.6(steroid )0.6(therap)12(y )0.6(w)13(as )0.6(69.5%, )0.6(and )0.5(steroid )0.6(resistance )0.6(occur)-15.9(red )0.5(in )0.6(30.5%. )]TJ 0.039 Tw T* [(P)18(ancolitis \(OR)]TJ /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (1.5; 95% CI: 1.1\2262\) and endoscopic picture on the UCEIS)Tj /Span<>> BDC ( )Tj EMC (\247)Tj /Span<>> BDC ( )Tj EMC (7 points \(OR)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (4.5; 95% CI: 3.2\2266.5\) )Tj 0.076 Tw 0 -1.111 TD [(w)12(ere p)46(redictors of steroid resistance. The lev)13.1(els of albumin and C-reactiv)13.1(e p)46(ro)13(tein before the star)-40(t and on the 3rd )]TJ -0.017 Tw 0 -1.111 TD [(d)26(ay of steroid treatment w)12(ere also signif)-43(icantly cor)-16(responded with adv)13.1(erse outcome of the treatment \(p)]TJ /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (0.00001\).)Tj 0.139 Tw T* [(C)21(ON)22(CLUSION: p)46(redictors of an adv)13(erse outcome are steroid resistance with pancolitis and endoscopic pictu\ re on )]TJ 0.052 Tw T* [(the UCEIS )0.5(scale \247)]TJ /Span<>> BDC ( )Tj EMC [(7 points. )0.5(Hypoalbuminemia )0.5(and )0.5(high lev)13(el of )0.5(C-reactiv)13(e )0.5(p)45.9(ro)13(tein w)12(ere associated with the steroid )]TJ 0.023 Tw T* [(resistance as w)12(ell.)]TJ ET 1 0.68 0 0.12 k /GS0 gs q 1 0 0 1 70.8661 561.1533 cm 0 0 m 0 0 l 0 -11.339 l 42.52 -11.339 l 42.52 0 l h f Q BT 0 0 0 0 k /T1_2 1 Tf 0 Tw 9 0 0 9 76.0071 552.226 Tm (\021\033\r\035\f\033)Tj ET 1 0.68 0 0.12 k q 1 0 0 1 70.8661 186.8604 cm 0 0 m 0 0 l 0 -11.339 l 42.52 -11.339 l 42.52 0 l h f Q BT 0 0 0 0 k /T1_2 1 Tf 9 0 0 9 73.5728 177.9331 Tm (ABSTRACT)Tj 1 0.68 0 0.12 k /T1_1 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\214)10(\211\036\033 \035\030\032\t\033)30(\b)42(\032)-21(\240\033\233)]TJ 57.136 0 Td (REVIEW)Tj -57.136 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 23, \023\0221)69(, 202)69(4)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 23, \023\0221)69(, 202)69(4)]TJ /T1_4 1 Tf 25 0 0 25 20.8276 56.0378 Tm (172)Tj ET q 0 g 0 G 0 j 0 J /Fm1 Do Q 0 0 0 0 k 396.85 725.67 59.155 11.338 re f /PlacedPDF /MC0 BDC q 397.481 736.808 m 397.242 736.808 397.049 736.616 397.049 736.376 c 397.049 736.376 l 397.049 726.285 l 397.049 726.045 397.242 725.853 397.481 725.853 c 397.481 725.853 l 455.382 725.853 l 455.62 725.853 455.815 726.045 455.815 726.285 c 455.815 726.285 l 455.815 736.376 l 455.815 736.616 455.62 736.808 455.382 736.808 c 455.382 736.808 l h W n q 0 g -0.0000005 -10.9560913 -10.9560913 0.0000005 426.4320445 736.8086309 cm BX /Sh0 sh EX Q Q q 396.85 725.67 59.155 11.337 re W n 0 0 0 0.84 k q 1 0 0 1 413.5634 732.4249 cm 0 0 m -0.025 0.1 -0.063 0.196 -0.112 0.287 c -0.157 0.374 -0.218 0.451 -0.292 0.515 c -0.37 0.582 -0.46 0.632 -0.558 0.664 c -0.669 0.701 -0.786 0.719 -0.903 0.717 c -1.076 0.722 -1.247 0.681 -1.4 0.6 c -1.536 0.526 -1.652 0.42 -1.74 0.292 c -1.83 0.158 -1.895 0.008 -1.934 -0.149 c -2.018 -0.48 -2.018 -0.827 -1.934 -1.158 c -1.896 -1.316 -1.83 -1.466 -1.74 -1.602 c -1.653 -1.731 -1.536 -1.837 -1.4 -1.912 c -1.247 -1.993 -1.076 -2.033 -0.903 -2.029 c -0.774 -2.032 -0.647 -2.006 -0.528 -1.955 c -0.427 -1.906 -0.337 -1.837 -0.263 -1.753 c -0.185 -1.665 -0.124 -1.563 -0.082 -1.453 c -0.034 -1.338 0 -1.218 0.019 -1.094 c 0.635 -1.094 l 0.624 -1.297 0.578 -1.497 0.497 -1.684 c 0.421 -1.857 0.312 -2.015 0.175 -2.146 c 0.039 -2.277 -0.123 -2.379 -0.3 -2.446 c -0.492 -2.519 -0.695 -2.555 -0.9 -2.552 c -1.15 -2.557 -1.397 -2.506 -1.625 -2.404 c -1.829 -2.307 -2.01 -2.169 -2.157 -1.997 c -2.308 -1.821 -2.423 -1.617 -2.497 -1.397 c -2.655 -0.924 -2.655 -0.412 -2.497 0.061 c -2.423 0.281 -2.307 0.485 -2.157 0.661 c -2.01 0.833 -1.829 0.973 -1.625 1.07 c -1.398 1.174 -1.15 1.226 -0.9 1.222 c -0.707 1.223 -0.515 1.196 -0.329 1.14 c -0.159 1.088 0.001 1.006 0.144 0.898 c 0.278 0.793 0.39 0.662 0.473 0.513 c 0.562 0.349 0.615 0.167 0.629 -0.019 c 0 -0.019 l 0 0 l f Q q 1 0 0 1 414.6923 733.5723 cm 0 0 m 0.584 0 l 0.584 -1.328 l 0.662 -1.204 0.771 -1.103 0.9 -1.033 c 1.046 -0.951 1.213 -0.91 1.381 -0.914 c 1.627 -0.9 1.869 -0.979 2.058 -1.137 c 2.234 -1.312 2.325 -1.556 2.305 -1.803 c 2.305 -3.596 l 1.716 -3.596 l 1.716 -1.976 l 1.724 -1.817 1.678 -1.66 1.585 -1.53 c 1.486 -1.43 1.347 -1.379 1.206 -1.392 c 1.114 -1.39 1.024 -1.408 0.94 -1.445 c 0.865 -1.479 0.798 -1.529 0.744 -1.591 c 0.687 -1.656 0.645 -1.73 0.616 -1.812 c 0.586 -1.896 0.571 -1.986 0.571 -2.077 c 0.571 -3.615 l 0 -3.615 l 0 0 l f Q q 1 0 0 1 418.0385 731.1235 cm 0 0 m 0 -0.099 0.014 -0.198 0.043 -0.292 c 0.069 -0.382 0.112 -0.466 0.17 -0.54 c 0.229 -0.611 0.304 -0.669 0.388 -0.709 c 0.486 -0.754 0.594 -0.776 0.702 -0.773 c 0.845 -0.78 0.987 -0.742 1.108 -0.664 c 1.217 -0.582 1.296 -0.468 1.336 -0.337 c 1.881 -0.337 l 1.827 -0.603 1.675 -0.838 1.456 -0.996 c 1.35 -1.073 1.231 -1.131 1.105 -1.169 c 0.971 -1.208 0.831 -1.229 0.691 -1.227 c 0.509 -1.227 0.328 -1.191 0.16 -1.121 c 0.007 -1.063 -0.13 -0.972 -0.244 -0.855 c -0.356 -0.73 -0.44 -0.583 -0.491 -0.422 c -0.548 -0.243 -0.576 -0.056 -0.574 0.133 c -0.575 0.313 -0.545 0.493 -0.486 0.664 c -0.426 0.826 -0.335 0.974 -0.22 1.102 c 0.004 1.375 0.338 1.534 0.691 1.535 c 0.883 1.539 1.072 1.495 1.243 1.408 c 1.402 1.326 1.541 1.209 1.649 1.067 c 1.759 0.922 1.838 0.757 1.883 0.582 c 1.932 0.396 1.945 0.203 1.92 0.013 c 0 0.013 l 0 0 l 1.342 0.377 m 1.335 0.468 1.315 0.557 1.283 0.643 c 1.253 0.724 1.209 0.798 1.153 0.863 c 1.097 0.922 1.03 0.97 0.957 1.004 c 0.874 1.043 0.783 1.063 0.691 1.062 c 0.6 1.062 0.509 1.044 0.425 1.009 c 0.345 0.976 0.273 0.926 0.213 0.863 c 0.153 0.799 0.105 0.724 0.072 0.643 c 0.037 0.559 0.017 0.468 0.014 0.377 c 1.355 0.377 l h f Q q 1 0 0 1 422.1581 731.7051 cm 0 0 m -0.012 0.144 -0.082 0.276 -0.194 0.366 c -0.31 0.452 -0.451 0.495 -0.595 0.489 c -0.675 0.488 -0.755 0.476 -0.831 0.452 c -0.918 0.424 -0.998 0.375 -1.062 0.311 c -1.142 0.229 -1.202 0.131 -1.24 0.024 c -1.29 -0.132 -1.312 -0.296 -1.304 -0.459 c -1.304 -0.569 -1.292 -0.677 -1.267 -0.784 c -1.244 -0.885 -1.202 -0.983 -1.145 -1.07 c -1.09 -1.154 -1.016 -1.224 -0.93 -1.275 c -0.833 -1.33 -0.722 -1.356 -0.611 -1.352 c -0.457 -1.357 -0.307 -1.301 -0.194 -1.195 c -0.078 -1.077 -0.005 -0.922 0.011 -0.757 c 0.587 -0.757 l 0.556 -1.055 0.419 -1.332 0.202 -1.538 c -0.022 -1.721 -0.306 -1.815 -0.595 -1.803 c -0.777 -1.806 -0.958 -1.771 -1.126 -1.7 c -1.293 -1.642 -1.445 -1.547 -1.57 -1.421 c -1.68 -1.297 -1.763 -1.151 -1.814 -0.993 c -1.87 -0.822 -1.898 -0.643 -1.896 -0.462 c -1.898 -0.276 -1.871 -0.091 -1.817 0.087 c -1.766 0.252 -1.682 0.405 -1.57 0.537 c -1.459 0.664 -1.323 0.766 -1.168 0.834 c -0.991 0.914 -0.798 0.955 -0.603 0.954 c -0.457 0.954 -0.311 0.935 -0.17 0.895 c -0.039 0.858 0.084 0.799 0.194 0.72 c 0.302 0.643 0.393 0.543 0.459 0.428 c 0.531 0.298 0.572 0.155 0.582 0.008 c 0 0.008 l 0 0 l f Q q 1 0 0 1 423.2177 733.5723 cm 0 0 m 0.577 0 l 0.577 -2.048 l 1.615 -0.985 l 2.322 -0.985 l 1.323 -1.944 l 2.417 -3.604 l 1.716 -3.604 l 0.919 -2.337 l 0.577 -2.669 l 0.577 -3.604 l 0 -3.604 l h f Q q 1 0 0 1 427.0585 732.5762 cm 0 0 m 0.436 0 l 0.436 0.218 l 0.429 0.352 0.448 0.486 0.488 0.614 c 0.521 0.705 0.577 0.786 0.651 0.85 c 0.717 0.905 0.795 0.943 0.879 0.961 c 0.966 0.979 1.056 0.988 1.145 0.988 c 1.28 0.993 1.416 0.981 1.548 0.954 c 1.548 0.505 l 1.509 0.516 1.469 0.523 1.429 0.528 c 1.379 0.532 1.33 0.532 1.28 0.528 c 1.209 0.53 1.14 0.511 1.081 0.473 c 1.019 0.419 0.987 0.337 0.999 0.255 c 0.999 -0.011 l 1.498 -0.011 l 1.498 -0.441 l 1.009 -0.441 l 1.009 -2.622 l 0.436 -2.622 l 0.436 -0.428 l 0.005 -0.428 l 0.005 0 l 0 0 l f Q q 1 0 0 1 430.1 729.8965 cm 0 0 m -0.191 -0.003 -0.381 0.032 -0.559 0.104 c -0.715 0.167 -0.856 0.264 -0.972 0.388 c -1.091 0.512 -1.181 0.659 -1.238 0.82 c -1.356 1.18 -1.356 1.567 -1.238 1.925 c -1.181 2.087 -1.091 2.234 -0.972 2.358 c -0.856 2.481 -0.715 2.578 -0.559 2.643 c -0.199 2.78 0.198 2.78 0.558 2.643 c 0.714 2.578 0.855 2.481 0.972 2.358 c 1.09 2.234 1.181 2.087 1.237 1.925 c 1.355 1.567 1.355 1.18 1.237 0.82 c 1.181 0.659 1.09 0.512 0.972 0.388 c 0.855 0.266 0.713 0.169 0.558 0.106 c 0.38 0.034 0.191 -0.002 0 0 c 0 0.454 m 0.115 0.451 0.23 0.479 0.332 0.534 c 0.424 0.586 0.502 0.659 0.562 0.746 c 0.624 0.836 0.669 0.936 0.695 1.041 c 0.752 1.26 0.752 1.491 0.695 1.71 c 0.669 1.816 0.625 1.916 0.562 2.005 c 0.502 2.091 0.423 2.163 0.332 2.215 c 0.123 2.323 -0.126 2.323 -0.335 2.215 c -0.427 2.163 -0.505 2.091 -0.566 2.005 c -0.628 1.916 -0.673 1.816 -0.699 1.71 c -0.756 1.491 -0.756 1.26 -0.699 1.041 c -0.672 0.936 -0.627 0.836 -0.566 0.746 c -0.506 0.659 -0.427 0.586 -0.335 0.534 c -0.232 0.478 -0.117 0.451 0 0.454 c f Q q 1 0 0 1 431.8979 732.5762 cm 0 0 m 0.531 0 l 0.531 -0.505 l 0.55 -0.43 0.583 -0.359 0.629 -0.297 c 0.681 -0.229 0.74 -0.167 0.807 -0.114 c 0.877 -0.059 0.956 -0.014 1.039 0.019 c 1.123 0.053 1.213 0.07 1.304 0.069 c 1.52 0.069 l 1.52 -0.486 l 1.395 -0.467 l 1.269 -0.467 l 1.178 -0.468 1.087 -0.488 1.004 -0.526 c 0.917 -0.565 0.839 -0.625 0.778 -0.699 c 0.716 -0.783 0.669 -0.878 0.643 -0.98 c 0.604 -1.104 0.584 -1.233 0.586 -1.362 c 0.586 -2.603 l 0.01 -2.603 l 0.01 0 l 0 0 l f Q q 1 0 0 1 437.3666 729.9683 cm 0 0 m -0.577 0 l -0.577 0.364 l -0.649 0.23 -0.759 0.121 -0.893 0.047 c -1.022 -0.029 -1.169 -0.07 -1.32 -0.072 c -1.595 -0.095 -1.866 0.002 -2.064 0.194 c -2.234 0.413 -2.316 0.687 -2.295 0.964 c -2.295 2.608 l -1.719 2.608 l -1.719 1.014 l -1.735 0.843 -1.689 0.67 -1.588 0.531 c -1.492 0.433 -1.357 0.382 -1.219 0.39 c -1.116 0.387 -1.012 0.406 -0.917 0.446 c -0.84 0.479 -0.772 0.531 -0.72 0.595 c -0.667 0.661 -0.63 0.738 -0.611 0.82 c -0.588 0.911 -0.577 1.003 -0.577 1.097 c -0.577 2.611 l 0 2.611 l 0 0 l f Q q 1 0 0 1 437.9877 732.5762 cm 0 0 m 0.545 0 l 0.545 -0.353 l 0.617 -0.209 0.736 -0.094 0.882 -0.026 c 1.03 0.04 1.19 0.073 1.352 0.072 c 1.535 0.075 1.717 0.038 1.883 -0.037 c 2.031 -0.106 2.161 -0.208 2.263 -0.334 c 2.366 -0.465 2.442 -0.615 2.489 -0.775 c 2.54 -0.948 2.566 -1.127 2.566 -1.307 c 2.566 -1.479 2.542 -1.651 2.497 -1.817 c 2.455 -1.973 2.385 -2.121 2.29 -2.252 c 2.099 -2.522 1.789 -2.682 1.458 -2.68 c 1.369 -2.681 1.28 -2.674 1.193 -2.659 c 1.11 -2.644 1.028 -2.618 0.951 -2.584 c 0.875 -2.552 0.802 -2.509 0.736 -2.457 c 0.671 -2.406 0.615 -2.343 0.571 -2.273 c 0.571 -3.575 l -0.005 -3.575 l -0.005 0 l 0 0 l 2.008 -1.307 m 2.008 -1.191 1.993 -1.076 1.963 -0.964 c 1.936 -0.859 1.89 -0.759 1.828 -0.669 c 1.768 -0.584 1.69 -0.514 1.599 -0.462 c 1.503 -0.409 1.395 -0.382 1.286 -0.385 c 1.072 -0.372 0.867 -0.467 0.738 -0.638 c 0.607 -0.836 0.543 -1.072 0.555 -1.31 c 0.554 -1.433 0.57 -1.557 0.603 -1.676 c 0.631 -1.781 0.68 -1.879 0.747 -1.965 c 0.809 -2.044 0.886 -2.109 0.975 -2.157 c 1.071 -2.206 1.178 -2.23 1.286 -2.229 c 1.401 -2.232 1.517 -2.205 1.618 -2.148 c 1.708 -2.096 1.785 -2.025 1.843 -1.939 c 1.903 -1.85 1.945 -1.751 1.968 -1.646 c 1.995 -1.535 2.008 -1.421 2.008 -1.307 c f Q q 1 0 0 1 443.5127 729.9683 cm 0 0 m -0.545 0 l -0.545 0.353 l -0.616 0.211 -0.734 0.099 -0.879 0.034 c -1.027 -0.031 -1.187 -0.065 -1.349 -0.064 c -1.532 -0.067 -1.714 -0.03 -1.88 0.045 c -2.028 0.113 -2.158 0.214 -2.26 0.34 c -2.364 0.47 -2.441 0.62 -2.486 0.781 c -2.538 0.958 -2.564 1.143 -2.563 1.328 c -2.568 1.536 -2.536 1.742 -2.468 1.938 c -2.41 2.097 -2.319 2.242 -2.202 2.364 c -2.101 2.471 -1.977 2.555 -1.838 2.608 c -1.705 2.659 -1.563 2.685 -1.421 2.685 c -1.338 2.685 -1.256 2.678 -1.174 2.664 c -1.091 2.648 -1.01 2.624 -0.932 2.589 c -0.855 2.556 -0.783 2.514 -0.717 2.462 c -0.652 2.411 -0.597 2.349 -0.553 2.279 c -0.553 3.606 l 0.024 3.606 l 0.024 0 l 0 0 l -2.008 1.277 m -2.009 1.166 -1.994 1.056 -1.965 0.948 c -1.939 0.845 -1.896 0.748 -1.835 0.661 c -1.777 0.578 -1.699 0.508 -1.61 0.459 c -1.404 0.355 -1.162 0.355 -0.956 0.459 c -0.866 0.512 -0.789 0.585 -0.73 0.671 c -0.671 0.762 -0.626 0.862 -0.6 0.966 c -0.572 1.076 -0.558 1.188 -0.558 1.301 c -0.543 1.542 -0.612 1.781 -0.751 1.979 c -0.88 2.14 -1.078 2.229 -1.283 2.22 c -1.402 2.224 -1.52 2.196 -1.623 2.138 c -1.714 2.083 -1.793 2.009 -1.852 1.92 c -1.911 1.828 -1.954 1.725 -1.977 1.617 c -1.999 1.505 -2.01 1.392 -2.008 1.277 c f Q q 1 0 0 1 446.3252 730.5499 cm 0 0 m -0.004 -0.052 0.005 -0.104 0.026 -0.151 c 0.052 -0.185 0.094 -0.202 0.136 -0.197 c 0.197 -0.197 l 0.223 -0.2 0.25 -0.2 0.276 -0.197 c 0.276 -0.595 l 0.199 -0.619 l 0.101 -0.64 l 0 -0.656 l -0.085 -0.656 l -0.187 -0.66 -0.288 -0.635 -0.377 -0.584 c -0.461 -0.528 -0.516 -0.437 -0.528 -0.337 c -0.648 -0.451 -0.792 -0.534 -0.951 -0.579 c -1.106 -0.628 -1.269 -0.654 -1.432 -0.656 c -1.546 -0.657 -1.659 -0.641 -1.769 -0.608 c -1.872 -0.579 -1.967 -0.531 -2.053 -0.468 c -2.136 -0.405 -2.203 -0.324 -2.25 -0.231 c -2.3 -0.127 -2.326 -0.012 -2.324 0.104 c -2.33 0.24 -2.299 0.375 -2.236 0.497 c -2.181 0.594 -2.101 0.675 -2.005 0.733 c -1.905 0.791 -1.795 0.833 -1.681 0.855 c -1.562 0.88 -1.442 0.899 -1.32 0.914 c -1.222 0.933 -1.123 0.947 -1.022 0.956 c -0.938 0.963 -0.855 0.977 -0.773 0.999 c -0.708 1.014 -0.649 1.046 -0.6 1.092 c -0.556 1.144 -0.533 1.211 -0.536 1.28 c -0.534 1.344 -0.553 1.408 -0.59 1.46 c -0.624 1.507 -0.668 1.544 -0.72 1.569 c -0.775 1.596 -0.834 1.613 -0.895 1.62 c -0.955 1.624 -1.016 1.624 -1.076 1.62 c -1.215 1.625 -1.354 1.591 -1.474 1.519 c -1.581 1.45 -1.647 1.333 -1.652 1.206 c -2.231 1.206 l -2.227 1.354 -2.185 1.498 -2.108 1.625 c -2.041 1.733 -1.951 1.824 -1.843 1.891 c -1.729 1.96 -1.603 2.007 -1.472 2.032 c -1.329 2.072 -1.183 2.098 -1.036 2.109 c -0.908 2.109 -0.781 2.096 -0.656 2.069 c -0.538 2.044 -0.425 2 -0.321 1.939 c -0.225 1.88 -0.143 1.8 -0.083 1.705 c -0.02 1.599 0.012 1.478 0.008 1.354 c 0.008 0.013 l 0 0 l -0.576 0.728 m -0.674 0.667 -0.785 0.631 -0.9 0.624 c -1.028 0.612 -1.155 0.594 -1.283 0.571 c -1.343 0.561 -1.402 0.547 -1.46 0.528 c -1.515 0.511 -1.566 0.485 -1.612 0.451 c -1.657 0.419 -1.692 0.376 -1.716 0.327 c -1.742 0.267 -1.755 0.203 -1.753 0.138 c -1.755 0.079 -1.735 0.021 -1.697 -0.024 c -1.661 -0.067 -1.615 -0.103 -1.564 -0.127 c -1.509 -0.154 -1.451 -0.171 -1.392 -0.181 c -1.335 -0.19 -1.278 -0.196 -1.222 -0.197 c -1.152 -0.196 -1.083 -0.188 -1.015 -0.173 c -0.94 -0.156 -0.87 -0.127 -0.805 -0.088 c -0.74 -0.048 -0.684 0.004 -0.64 0.066 c -0.594 0.134 -0.571 0.215 -0.574 0.297 c -0.574 0.725 l h f Q q 1 0 0 1 446.6836 732.5762 cm 0 0 m 0.434 0 l 0.434 0.784 l 0.996 0.784 l 0.996 0 l 1.527 0 l 1.527 -0.43 l 0.996 -0.43 l 0.996 -1.822 l 0.993 -1.874 0.993 -1.927 0.996 -1.979 c 1 -2.018 1.011 -2.056 1.031 -2.09 c 1.05 -2.122 1.079 -2.146 1.113 -2.159 c 1.162 -2.177 1.213 -2.185 1.265 -2.183 c 1.387 -2.183 l 1.428 -2.181 1.469 -2.175 1.509 -2.165 c 1.509 -2.608 l 1.323 -2.629 l 1.261 -2.633 1.199 -2.633 1.137 -2.629 c 1.013 -2.633 0.89 -2.619 0.771 -2.587 c 0.688 -2.564 0.613 -2.52 0.553 -2.459 c 0.499 -2.4 0.462 -2.328 0.446 -2.25 c 0.427 -2.155 0.416 -2.059 0.415 -1.963 c 0.415 -0.428 l -0.019 -0.428 l -0.019 0 l 0 0 l f Q q 1 0 0 1 449.0742 731.1235 cm 0 0 m 0 -0.099 0.014 -0.198 0.042 -0.292 c 0.068 -0.382 0.112 -0.466 0.17 -0.54 c 0.229 -0.611 0.303 -0.669 0.388 -0.709 c 0.486 -0.754 0.593 -0.776 0.701 -0.773 c 0.845 -0.78 0.987 -0.742 1.107 -0.664 c 1.216 -0.582 1.296 -0.468 1.336 -0.337 c 1.88 -0.337 l 1.827 -0.603 1.674 -0.838 1.456 -0.996 c 1.349 -1.073 1.231 -1.131 1.105 -1.169 c 0.973 -1.208 0.836 -1.228 0.699 -1.227 c 0.512 -1.23 0.327 -1.196 0.154 -1.126 c 0.003 -1.066 -0.133 -0.973 -0.244 -0.855 c -0.356 -0.73 -0.44 -0.583 -0.491 -0.422 c -0.548 -0.243 -0.576 -0.056 -0.574 0.133 c -0.575 0.313 -0.546 0.493 -0.486 0.664 c -0.426 0.826 -0.336 0.974 -0.221 1.102 c 0.002 1.374 0.334 1.532 0.685 1.535 c 0.877 1.539 1.067 1.495 1.238 1.408 c 1.396 1.326 1.535 1.209 1.644 1.067 c 1.753 0.922 1.833 0.757 1.878 0.582 c 1.927 0.396 1.939 0.203 1.915 0.013 c -0.002 0.013 l 0 0 l 1.341 0.377 m 1.335 0.468 1.315 0.557 1.283 0.643 c 1.253 0.724 1.209 0.798 1.153 0.863 c 1.096 0.926 1.027 0.978 0.951 1.014 c 0.868 1.054 0.777 1.074 0.685 1.073 c 0.594 1.073 0.504 1.055 0.419 1.02 c 0.339 0.986 0.267 0.937 0.207 0.874 c 0.147 0.81 0.099 0.735 0.066 0.653 c 0.031 0.569 0.011 0.479 0.008 0.388 c 1.349 0.388 l h f Q q 1 0 0 1 451.8657 730.7994 cm 0 0 m 0.002 -0.142 0.073 -0.274 0.191 -0.353 c 0.312 -0.423 0.45 -0.458 0.59 -0.454 c 0.651 -0.458 0.711 -0.458 0.773 -0.454 c 0.839 -0.447 0.904 -0.43 0.967 -0.406 c 1.024 -0.385 1.075 -0.349 1.116 -0.303 c 1.155 -0.252 1.174 -0.189 1.168 -0.125 c 1.166 -0.057 1.138 0.008 1.089 0.056 c 1.033 0.107 0.967 0.146 0.895 0.17 c 0.809 0.201 0.72 0.226 0.629 0.245 c 0.329 0.33 l 0.224 0.352 0.121 0.38 0.019 0.415 c -0.076 0.446 -0.166 0.491 -0.247 0.55 c -0.327 0.608 -0.391 0.683 -0.436 0.771 c -0.486 0.873 -0.511 0.986 -0.507 1.1 c -0.512 1.226 -0.475 1.351 -0.404 1.456 c -0.333 1.551 -0.243 1.63 -0.138 1.687 c -0.028 1.747 0.092 1.788 0.215 1.809 c 0.337 1.832 0.462 1.843 0.587 1.843 c 0.716 1.844 0.845 1.83 0.972 1.801 c 1.09 1.774 1.202 1.727 1.304 1.663 c 1.404 1.598 1.488 1.513 1.551 1.413 c 1.621 1.3 1.663 1.173 1.676 1.041 c 1.076 1.041 l 1.059 1.155 0.989 1.253 0.887 1.307 c 0.78 1.355 0.665 1.38 0.547 1.378 c 0.5 1.381 0.452 1.381 0.403 1.378 c 0.35 1.373 0.298 1.36 0.247 1.341 c 0.2 1.325 0.157 1.297 0.122 1.262 c 0.087 1.224 0.069 1.174 0.071 1.124 c 0.069 1.058 0.096 0.995 0.146 0.951 c 0.202 0.903 0.267 0.866 0.337 0.842 c 0.424 0.811 0.512 0.786 0.603 0.768 c 0.917 0.701 l 1.021 0.678 1.124 0.65 1.224 0.616 c 1.319 0.584 1.409 0.539 1.49 0.481 c 1.662 0.359 1.762 0.16 1.755 -0.05 c 1.76 -0.189 1.723 -0.326 1.649 -0.443 c 1.582 -0.551 1.491 -0.642 1.384 -0.709 c 1.267 -0.778 1.14 -0.827 1.007 -0.855 c 0.873 -0.885 0.735 -0.9 0.598 -0.9 c 0.443 -0.902 0.29 -0.883 0.141 -0.845 c 0.01 -0.812 -0.114 -0.753 -0.223 -0.674 c -0.324 -0.601 -0.407 -0.504 -0.465 -0.393 c -0.527 -0.269 -0.559 -0.131 -0.558 0.008 c 0.019 0.008 l 0 0 l f Q 0.146 0.941 0.992 0.044 k q 1 0 0 1 401.2527 729.3892 cm 0 0 m 3.612 2.406 l 3.612 5.296 l 0 5.296 l h f Q 0 0.889 0.676 0 k q 1 0 0 1 404.865 729.3892 cm 0 0 m -3.612 2.406 l -3.612 5.296 l 0 5.296 l h f Q 0.694 0.076 0.209 0 k q 1 0 0 1 403.0589 735.3145 cm 0 0 m -2.2 0 -3.984 -1.784 -3.984 -3.984 c -3.984 -6.184 -2.2 -7.968 0 -7.968 c 2.2 -7.968 3.984 -6.184 3.984 -3.984 c 3.984 -1.784 2.2 0 0 0 c 0 -6.993 m -1.662 -6.993 -3.009 -5.646 -3.009 -3.984 c -3.009 -2.322 -1.662 -0.975 0 -0.975 c 1.662 -0.975 3.009 -2.322 3.009 -3.984 c 3.009 -5.646 1.662 -6.993 0 -6.993 c f Q 0 0.235 0.86 0 k q 1 0 0 1 405.2601 729.2803 cm 0 0 m -1.118 -1.208 -3.015 -1.281 -4.237 -0.159 c -5.159 0.688 -5.459 2.005 -4.999 3.156 c -5.833 3.687 l -6.736 1.681 -5.843 -0.679 -3.836 -1.582 c -2.218 -2.311 -0.312 -1.881 0.836 -0.528 c 0 0 l f Q 0 0 0 0.6 k q 1 0 0 1 397.4813 736.8087 cm 0 0 m -0.238 0 -0.432 -0.193 -0.432 -0.432 c -0.432 -10.524 l -0.432 -10.763 -0.238 -10.956 0 -10.956 c 57.901 -10.956 l 58.139 -10.956 58.333 -10.763 58.333 -10.524 c 58.333 -0.432 l 58.333 -0.193 58.139 0 57.901 0 c h 57.901 -11.155 m 0 -11.155 l -0.348 -11.155 -0.631 -10.872 -0.631 -10.524 c -0.631 -0.432 l -0.631 -0.084 -0.348 0.199 0 0.199 c 57.901 0.199 l 58.249 0.199 58.532 -0.084 58.532 -0.432 c 58.532 -10.524 l 58.532 -10.872 58.249 -11.155 57.901 -11.155 c f Q EMC Q endstream endobj 274 0 obj <>/Properties<>>>/Subtype/Form>>stream 0 0 0 0 k /GS0 gs 464.066 725.668 60.343 11.34 re f /PlacedPDF /MC0 BDC 0 0 0 1 k 464.081 725.682 60.328 11.326 re 464.081 737.008 m 464.853 736.222 58.771 -9.769 re f q 464.066 725.668 60.343 11.34 re W n q 1 0 0 1 480.7374 735.5594 cm 0 0 m 0.962 -1.226 1.608 -2.673 1.608 -4.222 c 1.608 -5.781 0.951 -7.212 -0.023 -8.443 c 42.162 -8.443 l 42.162 0 l 0 0 l f Q 0 0 0 0.4 k q 1 0 0 1 467.8096 731.347 cm 0 0 m 0 1.495 0.569 2.789 1.707 3.882 c 1.83 4 1.957 4.108 2.086 4.212 c -2.233 4.212 l -2.233 -4.231 l 2.141 -4.231 l 1.992 -4.114 1.848 -3.989 1.707 -3.855 c 0.569 -2.78 0 -1.495 0 0 c f Q 0 0 0 1 k q 1 0 0 1 474.1234 732.5765 cm 0 0 m 0.317 0.306 0.72 0.458 1.21 0.458 c 1.921 0.458 2.431 0.193 2.738 -0.337 c 1.958 -0.707 l 1.813 -0.409 1.602 -0.26 1.322 -0.26 c 0.802 -0.26 0.542 -0.584 0.542 -1.233 c 0.542 -1.882 0.802 -2.207 1.322 -2.207 c 1.659 -2.207 1.896 -2.048 2.03 -1.732 c 2.753 -2.088 l 2.417 -2.653 1.912 -2.937 1.239 -2.937 c 0.72 -2.937 0.305 -2.786 -0.008 -2.485 c -0.32 -2.184 -0.476 -1.768 -0.476 -1.239 c -0.476 -0.719 -0.317 -0.306 0 0 c f Q q 1 0 0 1 473.5215 732.2396 cm 0 0 m -0.765 -0.37 l -0.909 -0.072 -1.125 0.077 -1.414 0.077 c -1.924 0.077 -2.179 -0.248 -2.179 -0.896 c -2.179 -1.545 -1.924 -1.87 -1.414 -1.87 c -1.077 -1.87 -0.837 -1.711 -0.692 -1.395 c 0.014 -1.751 l -0.323 -2.316 -0.828 -2.6 -1.502 -2.6 c -2.021 -2.6 -2.438 -2.449 -2.75 -2.148 c -3.064 -1.847 -3.22 -1.431 -3.22 -0.902 c -3.22 -0.382 -3.059 0.031 -2.736 0.337 c -2.414 0.643 -2.012 0.795 -1.531 0.795 c -0.818 0.795 -0.308 0.53 0 0 c f Q q 1 0 0 1 477.6864 735.2288 cm 0 0 m -0.125 0.118 -0.253 0.226 -0.383 0.331 c -1.737 0.331 l -0.144 -0.47 0.942 -2.052 0.943 -3.876 c 0.943 -3.882 l 0.945 -5.723 -0.161 -7.318 -1.777 -8.113 c -0.43 -8.113 l -0.273 -7.992 -0.121 -7.863 0.029 -7.723 c 1.128 -6.694 1.677 -5.413 1.677 -3.882 c 1.677 -2.351 1.118 -1.057 0 0 c f Q q 1 0 0 1 468.5439 731.3411 cm 0 0 m 0 0.006 l -0.001 1.832 1.085 3.417 2.681 4.218 c 1.352 4.218 l 1.223 4.114 1.095 4.005 0.972 3.888 c -0.166 2.794 -0.734 1.5 -0.734 0.006 c -0.734 -1.489 -0.166 -2.774 0.972 -3.849 c 1.113 -3.983 1.258 -4.108 1.406 -4.225 c 2.72 -4.225 l 1.105 -3.431 0.001 -1.839 0 0 c f Q 0 0 0 0.4 k q 1 0 0 1 480.7374 735.5594 cm 0 0 m -3.435 0 l -3.305 -0.104 -3.176 -0.213 -3.052 -0.33 c -1.934 -1.387 -1.375 -2.682 -1.375 -4.212 c -1.375 -5.744 -1.924 -7.023 -3.023 -8.054 c -3.172 -8.193 -3.325 -8.322 -3.481 -8.443 c -0.023 -8.443 l 0.951 -7.212 1.608 -5.781 1.608 -4.222 c 1.608 -2.673 0.962 -1.226 0 0 c f Q 0 0 0 0 k q 1 0 0 1 487.7984 733.4471 cm 0 0 m 1.271 0 l 2.298 -1.508 l 3.324 0 l 4.599 0 l 2.881 -2.45 l 2.881 -4.232 l 1.718 -4.232 l 1.718 -2.45 l 0 0 l -0.685 -1.967 m -0.436 -2.035 -0.241 -2.161 -0.104 -2.344 c 0.032 -2.528 0.101 -2.752 0.101 -3.02 c 0.101 -3.427 -0.047 -3.731 -0.341 -3.932 c -0.634 -4.133 -1.081 -4.232 -1.682 -4.232 c -3.611 -4.232 l -3.611 0 l -1.865 0 l -1.239 0 -0.786 -0.088 -0.506 -0.267 c -0.225 -0.443 -0.084 -0.729 -0.084 -1.119 c -0.084 -1.326 -0.135 -1.501 -0.237 -1.647 c -0.341 -1.791 -0.489 -1.898 -0.685 -1.967 c -1.766 -3.49 m -1.532 -3.49 -1.357 -3.443 -1.24 -3.351 c -1.121 -3.259 -1.062 -3.119 -1.062 -2.931 c -1.062 -2.748 -1.121 -2.61 -1.237 -2.521 c -1.354 -2.428 -1.53 -2.381 -1.766 -2.381 c -2.449 -2.381 l -2.449 -3.49 l -1.766 -3.49 l -1.806 -1.639 m -1.622 -1.639 -1.482 -1.601 -1.389 -1.525 c -1.294 -1.45 -1.246 -1.338 -1.246 -1.19 c -1.246 -1.045 -1.294 -0.934 -1.389 -0.858 c -1.482 -0.781 -1.622 -0.742 -1.806 -0.742 c -2.449 -0.742 l -2.449 -1.639 l -1.806 -1.639 l f Q q 1 0 0 1 497.3524 730.9329 cm 0 0 m 0 0.951 l 0 1.209 0.014 1.473 0.033 1.751 c 0.007 1.751 l -0.132 1.473 -0.244 1.222 -0.39 0.951 c -0.965 0.013 l -0.965 0 l h 0 -1.777 m 0 -0.753 l -1.902 -0.753 l -1.902 -0.099 l -0.277 2.517 l 0.951 2.517 l 0.951 0 l 1.467 0 l 1.467 -0.753 l 0.951 -0.753 l 0.951 -1.777 l 0 -1.777 l f Q q 1 0 0 1 499.2934 729.6907 cm 0 0 m 0 0.357 0.245 0.614 0.595 0.614 c 0.945 0.614 1.183 0.363 1.183 0 c 1.183 -0.35 0.945 -0.608 0.588 -0.608 c 0.245 -0.608 0 -0.35 0 0 c f Q q 1 0 0 1 501.9034 731.2963 cm 0 0 m -0.007 -0.984 0.229 -1.454 0.621 -1.454 c 1.011 -1.454 1.222 -0.964 1.222 0.013 c 1.222 0.965 1.018 1.467 0.614 1.467 c 0.244 1.467 -0.007 0.998 0 0 c 2.227 0.026 m 2.227 -1.302 1.69 -2.213 0.595 -2.213 c -0.517 -2.213 -1.005 -1.216 -1.012 0 c -1.012 1.242 -0.482 2.227 0.627 2.227 c 1.777 2.227 2.227 1.203 2.227 0.026 c f Q EMC Q endstream endobj 287 0 obj <> endobj 288 0 obj <>stream Adobe Graphics Manager 2021-04-12T11:52:16+05:00 2021-04-12T11:52:16+05:00 Acrobat Distiller 10.1.16 (Windows) CCBYv40_logo.ai densen endstream endobj 273 0 obj <> endobj 289 0 obj <>stream Adobe Illustrator CS6 (Windows) 2021-04-12T11:45:36+05:00 2021-06-02T10:28:09+05:00 2021-06-02T10:28:09+05:00 1 False False 20.868494 3.999928 Millimeters Cyan Magenta Yellow Black Default Swatch Group 0 C=0 M=24 Y=86 K=0 PROCESS 100.000000 CMYK 0.000000 23.504999 86.022697 0.000000 C=69 M=8 Y=21 K=0 PROCESS 100.000000 CMYK 69.369003 7.635600 20.892700 0.000000 C=0 M=89 Y=68 K=0 PROCESS 100.000000 CMYK 0.000000 88.946404 67.623398 0.000000 C=15 M=94 Y=99 K=4 PROCESS 100.000000 CMYK 14.578501 94.070297 99.160698 4.416000 C=0 M=0 Y=0 K=84 PROCESS 100.000000 CMYK 0.000000 0.000000 0.000000 84.000000 C=0 M=0 Y=0 K=35 PROCESS 100.000000 CMYK 0.000000 0.000000 0.000000 35.000000 C=0 M=0 Y=0 K=60 PROCESS 100.000000 CMYK 0.000000 0.000000 0.000000 60.000004 Document application/pdf proof:pdf xmp.did:804244B35A9BEB118A6FC3C256996E2F uuid:08e30110-bdb7-4606-97ca-63fb62cbcecc uuid:21079f76-f6d7-4329-b725-f2fb35af5114 uuid:722f8893-0b3c-4402-87fb-c713f1fa0e26 uuid:21079f76-f6d7-4329-b725-f2fb35af5114 uuid:21079f76-f6d7-4329-b725-f2fb35af5114 proof:pdf saved xmp.iid:804244B35A9BEB118A6FC3C256996E2F 2021-04-12T11:45:42+05:00 Adobe Illustrator CS6 (Windows) / endstream endobj 286 0 obj <>/Border[0 0 0]/H/N/Rect[394.85 739.008 458.005 723.67]/Subtype/Link/Type/Annot>> endobj 290 0 obj <> endobj 269 0 obj [291 0 R 292 0 R 293 0 R 294 0 R 295 0 R 296 0 R 297 0 R 298 0 R 299 0 R 300 0 R 301 0 R 302 0 R 303 0 R 304 0 R 305 0 R 306 0 R 307 0 R 308 0 R] endobj 270 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\037)31(\025\007\025\002\016\n)-10(\026)11(\013\007\216\001\020\203 \002\013\n, \013\006\006\025\227\220\220\002\025\ \r\013\001\001\020\203 \006\022\221\013\002\013\026\202)10(\025\002\024\025\001-)]TJ 0 -1 TD [(\002\025\201\006)-10(\026\r\016\001\001\020\024 \221\002\025\026)11(\016\220\001\025\024 \(\025\f\222\025\002 \007\220\026)11(\016\002\013\026)-19.9(\215\002\020\))]TJ 42.257 1 Td [(Color)31(ectal cancer associated with par)21(ath)31(yr)20(oid )]TJ 4.983 -1 Td [(h)11(ormone)-52(-r)31.1(elated pr)20(otein \(r)31(e)11(vie)11(w\))]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf -0.038 Tw 8 0 0 8 42.5197 731.2159 Tm (54.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Chen)Tj /Span<>> BDC ( )Tj EMC (Y, Deng)Tj /Span<>> BDC ( )Tj EMC [(G, F)10(u)]TJ /Span<>> BDC ( )Tj EMC [(Y, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. FO)17(X)17.1(C2 P)35(r)-32(omo)17(tes Ox)-11(al)-31(ipl)-15.9(a)15(t)-32(in R)13(esist)15(ance )]TJ 0.011 Tc 0.413 Tw -1.796 -1.25 Td [(b)11.9(y Induc)-24.1(ing Epi)-24.1(t)-13.1(hel)-31.1(ial-Mesenchymal T)49.8(r)-33.1(ansi)-24.1(t)-32.1(ion v)-16.1(ia MAPK/ERK)11.1( )]TJ 0 Tc 0.225 Tw 0 -1.25 TD [(S)-16(ignal)-30.9(ing in Col)30(or)-24(ec)-16(t)15(al Cancer. )]TJ /T1_2 1 Tf [(Onco T)53.9(arg)12.1(ets Ther)]TJ /T1_1 1 Tf (. 2020;13:1625\226)Tj 0.023 Tw T* [(1635. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.2147/OTT.S241367)Tj 0 0 0 1 k /GS1 gs 0.071 Tw T* (55.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Naba)Tj /Span<>> BDC ( )Tj EMC [(NM, T)45(ol)-16(a)15(y)]TJ /Span<>> BDC ( )Tj EMC [(N, Er)-16(man)]TJ /Span<>> BDC ( )Tj EMC [(B, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Do)13.9(x)10.1(or)-22(ubic)-24(in inhibi)-23.9(ts miR-140 )]TJ 0.052 Tw -1.796 -1.25 Td [(e)-18(xp)25(r)-23.9(ession and up)25(r)-23.9(egul)-16(a)15(tes PD-L1 e)-17.9(xp)25(r)-24(ession in HCT116 cells, oppo)]TJ 0 Tw (-)Tj 0.05 Tw T* [(si)-24(te t)17(o i)-24(ts ef)-56(fec)-16(ts on MD)20(A-MB-231 cells. )]TJ /T1_2 1 Tf [(T)57(urk J Biol)]TJ /T1_1 1 Tf (. 2020;44\(1\):15\226)Tj 0.023 Tw T* [(23. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.3906/biy-1909-12)Tj 0 0 0 1 k /GS1 gs 0.071 Tw T* (56.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Zhou)Tj /Span<>> BDC ( )Tj EMC (X, Xiao)Tj /Span<>> BDC ( )Tj EMC [(D. L)35(ong non-coding RN)13(A GA)35(S5 is cr)-36.9(i)-24(t)-32(ical for main)]TJ 0 Tw (-)Tj 0.13 Tw -1.796 -1.25 Td [(t)15(aining stemness and induces )0.5(chemor)-24(esist)15.1(ance in cancer )0.5(stem-l)-31(ik)10(e )]TJ 0.007 Tc 0.349 Tw T* [(cells der)-36.6(i)-15.6(ved fr)-31.6(om HCT116.)]TJ /T1_2 1 Tf ( Oncol Lett. )Tj /T1_1 1 Tf -0.007 Tw [(2020;19\(5\):3431\2263438.)7( )]TJ 0 Tc 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.3892/ol.2020.11471)Tj 0 0 0 1 k /GS1 gs 0.002 Tc 0.349 Tw -1.847 -1.25 Td (57.)Tj /Span<>> BDC ( )Tj EMC 1.803 0 Td [(N)-13.8(ovoaD\355a)-23.8(z)]TJ /Span<>> BDC ( )Tj EMC [(MB, Car)-23.8(r)-36.7(ier)-23.8(e)]TJ /Span<>> BDC ( )Tj EMC [(P, Gigol)-15.7(a)]TJ /Span<>> BDC ( )Tj EMC [(G, e)-11.7(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Invol)30.3(vement of)2( )]TJ 0 Tc 0.305 Tw -1.803 -1.25 Td [(Me)-12(t )0.5(r)-24(ecept)17(or )0.5(p)32(a)15(t)-13(hw)-11.9(a)15(y in )0.5(a)-17(ggr)-23.9(essi)-16(ve )0.5(behav)-16(ior )0.5(of )0.5(col)30(or)-24(ec)-16(t)15.1(al can)]TJ 0 Tw (-)Tj 0.258 Tw T* [(cer )0.6(cells )0.5(induced )0.6(b)12(y )0.6(p)32(ar)-33(a)15(t)-13(hyr)-32(oid )0.6(hor)-16(mone-r)-23.9(el)-16(a)15(ted )0.6(pept)-32(ide. )]TJ /T1_2 1 Tf 0 Tw 25.454 0 Td [(W)29(orld )]TJ 0.31 Tw -25.454 -1.25 Td (J Gastroenterol.)Tj /T1_1 1 Tf [( 2022b;28\(26\):3177\2263200. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.3748/wjg.v28.)Tj T* (i26.3177)Tj 0 0 0 1 k /GS1 gs 0.244 Tw T* (58.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Choi)Tj /Span<>> BDC ( )Tj EMC [(Y)15.1(J, Kim)]TJ /Span<>> BDC ( )Tj EMC (JH, Rho)Tj /Span<>> BDC ( )Tj EMC [(JK, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. AXL and MET r)-24(ecept)17(or t)-10(yr)-32(o)]TJ 0 Tw (-)Tj 0.231 Tw -1.796 -1.25 Td [(sine k)-16(inases ar)-24(e essent)-32(ial for l)35(ung cancer me)-12(t)15(ast)15(asis)]TJ /T1_2 1 Tf [(. Oncol R)21(ep.)]TJ /T1_1 1 Tf 0 Tw ( )Tj 0.023 Tw T* [(2017;37\(4\):2201\2262208. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.3892/or.2017.5482)Tj 0 0 0 1 k /GS1 gs 0.289 Tw T* (59.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Mezqui)-23.9(t)15(a)]TJ /Span<>> BDC ( )Tj EMC [(B, P)-24(ined)42(a)]TJ /Span<>> BDC ( )Tj EMC [(E, Mezqui)-23.9(t)15(a)]TJ /Span<>> BDC ( )Tj EMC [(J, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. L)35(oV)29(o col)30(on cancer )]TJ 0.223 Tw -1.796 -1.25 Td [(cells r)-24(esist)15.1(ant t)17(o o)14(x)-11(al)-31(ipl)-15.9(a)15(t)-32(in over)-23.9(e)-18(xp)25(r)-24(ess c-MET and VEGFR-1 and )]TJ 0.231 Tw T* [(r)-24(espond t)17(o VEGF wi)-24(t)-13(h dephosphor)-23.9(yl)-16(a)15(t)-32(ion of c-MET. )]TJ /T1_2 1 Tf (Mol Carcinog.)Tj /T1_1 1 Tf 0 Tw ( )Tj 0.023 Tw T* [(2016;55\(5\):411\2269. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1002/mc.22289)Tj 0 0 0 1 k /GS1 gs 0.173 Tw T* (60.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(W)12(ang)]TJ /Span<>> BDC ( )Tj EMC 2.579 0 Td [(S, )0.5(Qiu)]TJ /Span<>> BDC ( )Tj EMC 2.812 0 Td [(J, )0.6(L)-32(iu)]TJ /Span<>> BDC ( )Tj EMC 2.72 0 Td [(L, )0.5(e)-11.9(t)]TJ /Span<>> BDC ( )Tj EMC 2.271 0 Td [(al. )0.6(CREB5 )0.5(p)25(r)-32(omo)17.1(tes )0.5(inv)-15(asi)-15.9(veness )0.6(and )]TJ 0.029 Tw -12.178 -1.25 Td [(me)-12(t)15(ast)15.1(asis in col)30.1(or)-24(ec)-16(t)15(al cancer b)12(y dir)-23.9(ec)-16(tl)35(y a)-17(c)-16(t)-32(i)-16(v)-15(a)15(t)-32(ing MET. )]TJ /T1_2 1 Tf (J Exp Clin )Tj 0.023 Tw T* [(Cancer R)21(es.)]TJ /T1_1 1 Tf [( 2020;39\(1\):168. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1186/s13046-020-01673-0)Tj 0 0 0 1 k /GS1 gs -0.071 Tw 29.055 32.5 Td (61.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Ma)Tj /Span<>> BDC ( )Tj EMC (DJ, Cao)Tj /Span<>> BDC ( )Tj EMC [(Z, W)11.9(ang)]TJ /Span<>> BDC ( )Tj EMC [(BS, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Ef)-55.9(fec)-16(t of silenc)-23.9(ing hep)32(a)15(t)17(o)-16(cy)-16(te gr)-32(o)-13.9(w)-24(t)-13(h )]TJ 0.266 Tw -1.796 -1.25 Td [(f)16(a)-17(c)-16(t)17(or r)-23.9(ecept)17(or c-Me)-12(t e)-18(xp)25(r)-23.9(ession on biol)30(o)-16(gical char)-32.9(a)-17(c)-16(ter)-37(ist)-32(ics of )]TJ 0.032 Tw T* [(col)30(on cancer cells. )]TJ /T1_2 1 Tf (Zhonghua Zhong Liu Za Zhi.)Tj /T1_1 1 Tf ( 2020;42\(5\):362\226368. )Tj 0.023 Tw T* [(Chinese. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.3760/cma.j.cn112152-112152-20191106-00714)Tj 0 0 0 1 k /GS1 gs 0.294 Tw T* (62.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Cai)Tj /Span<>> BDC ( )Tj EMC (P, Xie)Tj /Span<>> BDC ( )Tj EMC (Y, Dong)Tj /Span<>> BDC ( )Tj EMC [(M, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Inhibi)-23.9(t)-32(ion of MEIS3 Gener)-33(a)15(tes )]TJ 0.001 Tc 0.35 Tw -1.796 -1.25 Td [(Ce)-12.4(tuximab R)12.6(esist)14.7(ance t)-13.3(hr)-32.4(ough c-Me)-12.3(t and Ak)-24.3(t. )]TJ /T1_2 1 Tf [(Biomed R)20.7(es Int.)]TJ /T1_1 1 Tf 0 Tc 0 Tw 27.638 0 Td ( )Tj 0.023 Tw -27.638 -1.25 Td [(2020;2020:2046248. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1155/2020/2046248)Tj 0 0 0 1 k /GS1 gs -0.037 Tw T* (63.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(S)-16(hal)-31(i)]TJ /Span<>> BDC ( )Tj EMC (H, Ahmadi)Tj /Span<>> BDC ( )Tj EMC [(M, K)-16(af)-28(il)]TJ /Span<>> BDC ( )Tj EMC [(HS, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. IGF1R and c-me)-12(t as t)-13(her)-33(apeut)-31.9(ic )]TJ 0.16 Tw -1.796 -1.25 Td [(t)15(ar)-32(ge)-12(ts for col)30.1(or)-24(ec)-16(t)15(al cancer. )]TJ /T1_2 1 Tf [(Biomed Phar)-13.9(maco)13(ther)]TJ /T1_1 1 Tf (. 2016;82:528\226)Tj 0.023 Tw T* [(36. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1016/j.biopha.2016.05.034)Tj 0 0 0 1 k /GS1 gs 0.041 Tw T* (64.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(L)35(ee)]TJ /Span<>> BDC ( )Tj EMC [(SJ, L)35(ee)]TJ /Span<>> BDC ( )Tj EMC [(J, P)40(ar)-24(k)]TJ /Span<>> BDC ( )Tj EMC [(SH, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. c-MET O)-24(ver e)-18(xp)25(r)-24(ession in Col)30(or)-23.9(ec)-16(t)15(al )]TJ 0.054 Tw -1.796 -1.25 Td [(Cancer: A P)10(o)-16(or P)35(r)-32(o)-15.9(gnost)-32(ic F)20(a)-17(c)-16(t)17(or for Sur)-32(v)-16(i)-15.9(v)-15(al. )]TJ /T1_2 1 Tf (Clin Colorectal Cancer. )Tj /T1_1 1 Tf 0.023 Tw T* [(2018 Sep;17\(3\):165\226169. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw [(10.1016/j.cl)16(cc.2018.02.013)]TJ 0 0 0 1 k /GS1 gs 0.293 Tw T* (65.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Gao)Tj /Span<>> BDC ( )Tj EMC (W, Bing)Tj /Span<>> BDC ( )Tj EMC [(X, L)-32(i)]TJ /Span<>> BDC ( )Tj EMC [(M, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. S)15.1(tud)17(y of cr)-37(i)-23.9(t)-32(ical r)-32(ole of c-Me)-12(t )]TJ 0.001 Tc 0.349 Tw -1.796 -1.25 Td [(and i)-23.7(ts inhibi)-23.7(t)17.4(or SU11274 in col)30.4(or)-23.6(ec)-15.6(t)15.3(al car)-31.6(c)-23.7(inoma. )]TJ /T1_2 1 Tf [(Med Oncol.)1( )]TJ /T1_1 1 Tf 0 Tc 0.023 Tw T* [(2013;30\(2\):546. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1007/s12032-013-0546-3)Tj 0 0 0 1 k /GS1 gs 0.248 Tw T* (66.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Br)-33(able)-11.9(tz)]TJ /Span<>> BDC ( )Tj EMC (T, Jung)Tj /Span<>> BDC ( )Tj EMC [(A, Da)-17(g)]TJ /Span<>> BDC ( )Tj EMC [(S, e)-11.9(t)]TJ /Span<>> BDC ( )Tj EMC [(al. be)-11.9(t)15(a-ca)15(tenin r)-24(egul)-15.9(a)15(tes t)-13(he )]TJ 0.193 Tw -1.796 -1.25 Td [(e)-18(xp)25(r)-23.9(ession of t)-12.9(he ma)15(tr)-37(ix me)-12(t)15(all)30(op)25(r)-32(o)17(teinase-7 in human col)30(or)-24(ec)-16(t)15(al )]TJ 0 Tw T* (cancer. )Tj /T1_2 1 Tf 0.332 Tw 3.499 0 Td [(Am J P)18(athol. )]TJ /T1_1 1 Tf [(1999;155\(4\):1033\2268. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1016/s0002-)Tj -3.499 -1.25 Td (9440\(10\)65204-2)Tj 0 0 0 1 k /GS1 gs 0.223 Tw T* (67.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Chou)Tj /Span<>> BDC ( )Tj EMC 2.459 0 Td [(YS, )0.6(Y)50(ang)]TJ /Span<>> BDC ( )Tj EMC 3.953 0 Td [(MH. )0.6(Epi)-24(t)-13(hel)-30.9(ial-mesenchymal )0.6(tr)-32.9(ansi)-24(t)-32(ion-r)-23.9(el)-16(a)15(ted )]TJ 0.199 Tw -8.208 -1.25 Td [(f)16(a)-17(c)-16(t)17(or)-9.9(s in sol)-31(id tumor and hema)15(t)17(ol)30(o)-16(gical mal)-30.9(ignancy. J )]TJ /T1_2 1 Tf (Chin Med )Tj 0 Tw T* (Assoc)Tj /T1_1 1 Tf 0.023 Tw [(. 2015;78\(8\):438\22645. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1016/j.jcma.2015.05.002)Tj 0 0 0 1 k /GS1 gs 0.105 Tw T* (68.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Car)-24(r)-36.9(ier)-24(e)]TJ /Span<>> BDC ( )Tj EMC [(P, Cal)30.1(vo)]TJ /Span<>> BDC ( )Tj EMC [(N, N)-14(ovoa D\355a)-24(z)]TJ /Span<>> BDC ( )Tj EMC [(MB, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. R)11(ole of SP)25.1(ARC in t)-13(he )]TJ -0.001 Tw -1.796 -1.25 Td [(epi)-24(t)-12.9(hel)-31(ial-mesenchymal tr)-32.9(ansi)-24(t)-32(ion induced b)12(y PTHrP in human col)30.1(on )]TJ 0.101 Tw T* (cancer cells. )Tj /T1_2 1 Tf [(Mol Cell Endocr)-36.9(inol)]TJ /T1_1 1 Tf [(. 2021;530:111253. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1016/j.)Tj T* (mce.2021.111253)Tj /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\214)10(\211\036\033 \035\030\032\t\033)30(\b)42(\032)-21(\240\033\233)]TJ 57.136 0 Td (REVIEW)Tj /T1_3 1 Tf 25 0 0 25 504.7145 56.0378 Tm (171)Tj ET endstream endobj 291 0 obj <>/Border[0 0 0]/H/N/Rect[77.716 708.512 149.524 699.216]/Subtype/Link/Type/Annot>> endobj 292 0 obj <>/Border[0 0 0]/H/N/Rect[69.716 668.512 139.052 659.216]/Subtype/Link/Type/Annot>> endobj 293 0 obj <>/Border[0 0 0]/H/N/Rect[57.2978 628.512 134.017 619.216]/Subtype/Link/Type/Annot>> endobj 294 0 obj <>/Border[0 0 0]/H/N/Rect[206.151 588.512 263.622 579.056]/Subtype/Link/Type/Annot>> endobj 295 0 obj <>/Border[0 0 0]/H/N/Rect[42.5197 578.512 71.1195 569.216]/Subtype/Link/Type/Annot>> endobj 296 0 obj <>/Border[0 0 0]/H/N/Rect[136.94 548.512 210.107 539.216]/Subtype/Link/Type/Annot>> endobj 297 0 obj <>/Border[0 0 0]/H/N/Rect[120.94 508.512 182.483 499.216]/Subtype/Link/Type/Annot>> endobj 298 0 obj <>/Border[0 0 0]/H/N/Rect[149.96 478.512 247.431 469.056]/Subtype/Link/Type/Annot>> endobj 299 0 obj <>/Border[0 0 0]/H/N/Rect[319.013 708.512 484.956 699.216]/Subtype/Link/Type/Annot>> endobj 300 0 obj <>/Border[0 0 0]/H/N/Rect[359.013 678.512 436.469 669.216]/Subtype/Link/Type/Annot>> endobj 301 0 obj <>/Border[0 0 0]/H/N/Rect[302.157 648.512 401.876 639.216]/Subtype/Link/Type/Annot>> endobj 302 0 obj <>/Border[0 0 0]/H/N/Rect[374.887 618.512 464.934 609.216]/Subtype/Link/Type/Annot>> endobj 303 0 obj <>/Border[0 0 0]/H/N/Rect[344.933 588.512 438.404 579.216]/Subtype/Link/Type/Annot>> endobj 304 0 obj <>/Border[0 0 0]/H/N/Rect[444.223 558.512 496.063 549.056]/Subtype/Link/Type/Annot>> endobj 305 0 obj <>/Border[0 0 0]/H/N/Rect[274.961 548.512 331.696 539.216]/Subtype/Link/Type/Annot>> endobj 306 0 obj <>/Border[0 0 0]/H/N/Rect[379.015 518.512 471.83 509.056]/Subtype/Link/Type/Annot>> endobj 307 0 obj <>/Border[0 0 0]/H/N/Rect[461.551 488.512 496.063 479.056]/Subtype/Link/Type/Annot>> endobj 308 0 obj <>/Border[0 0 0]/H/N/Rect[274.961 478.512 332.696 469.216]/Subtype/Link/Type/Annot>> endobj 326 0 obj <> endobj 325 0 obj <> endobj 324 0 obj <> endobj 323 0 obj <> endobj 322 0 obj <> endobj 321 0 obj <> endobj 320 0 obj <> endobj 319 0 obj <> endobj 318 0 obj <> endobj 317 0 obj <> endobj 316 0 obj <> endobj 315 0 obj <> endobj 314 0 obj <> endobj 313 0 obj <> endobj 312 0 obj <> endobj 311 0 obj <> endobj 310 0 obj <> endobj 309 0 obj <> endobj 66 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 67 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 68 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 69 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 70 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 332 0 obj [334 0 R 335 0 R 336 0 R 337 0 R 338 0 R 339 0 R 340 0 R 341 0 R 342 0 R 343 0 R 344 0 R 345 0 R 346 0 R 347 0 R 348 0 R 349 0 R 350 0 R 351 0 R 352 0 R 353 0 R 354 0 R 355 0 R 356 0 R 357 0 R 358 0 R 359 0 R 360 0 R 361 0 R 362 0 R 363 0 R 364 0 R 365 0 R 366 0 R 367 0 R 368 0 R 369 0 R 370 0 R 371 0 R 372 0 R 373 0 R 374 0 R 375 0 R 376 0 R 377 0 R] endobj 333 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.212 Tw 8 0 0 8 70.8661 731.2159 Tm [(p)25(r)-32(o)17(tein dur)-37(ing chemo)17(t)-12.9(her)-33(apy: a case r)-23.9(epor)-22(t. )]TJ /T1_1 1 Tf (Clin J Gastroenterol)Tj /T1_0 1 Tf 0 Tw (. )Tj 0.023 Tw 0 -1.25 TD [(2016;9\(2\):68\22672. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1007/s12328-016-0636-9)Tj 0 0 0 1 k /GS1 gs 0.051 Tw T* (17.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Deans)Tj /Span<>> BDC ( )Tj EMC [(C, W)-16(igmor)-24(e)]TJ /Span<>> BDC ( )Tj EMC [(S, P)40(a)15(ter)-10(son-Br)-31.9(o)-14(wn)]TJ /Span<>> BDC ( )Tj EMC [(S, e)-11.9(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Ser)-21.9(um p)32(ar)-33(a)15(t)-13(hyr)-32(oid )]TJ 0.339 Tw -1.796 -1.25 Td [(hor)-16(mone-r)-23.9(el)-16(a)15(ted pept)-31.9(ide is asso)-16(c)-24(ia)15(ted wi)-24(t)-13(h sy)-13(stemic infl)-16(amma)]TJ 0 Tw (-)Tj 0.088 Tw T* [(t)-32(ion and ad)-17(ver)-9.9(se p)25(r)-32(o)-16(gnosis )0.5(in gastr)-32(oesopha)-17(geal )0.5(car)-32(c)-24(inoma. )]TJ /T1_1 1 Tf 0 Tw (Cancer)Tj /T1_0 1 Tf (. )Tj 0.023 Tw T* [(2005;103\(9\):1810\2268. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1002/cncr.20972)Tj 0 0 0 1 k /GS1 gs 0.051 Tw T* (18.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(P)40(ar)-24(r)-36.9(i)]TJ /Span<>> BDC ( )Tj EMC [(M, Chiar)-22(ugi)]TJ /Span<>> BDC ( )Tj EMC [(P. R)-9.9(a)-17(c and Rho G)-12(TP)40(ases in cancer cell mo)17.1(t)-32(il)-31(i)-24(t)-10(y )]TJ 0 Tw -1.796 -1.25 Td [(contr)-32(ol. )]TJ /T1_1 1 Tf 0.189 Tw 3.632 0 Td (Cell Commun Signal)Tj /T1_0 1 Tf [(. 2010;8:23. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1186/1478-811X-)Tj -3.632 -1.25 Td (8-23)Tj 0 0 0 1 k /GS1 gs 0.203 Tw T* (19.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Xu)Tj /Span<>> BDC ( )Tj EMC [(C, W)12(ang)]TJ /Span<>> BDC ( )Tj EMC (Z, Cui)Tj /Span<>> BDC ( )Tj EMC [(R, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Co-e)-17.9(xp)25(r)-24(ession of p)32(ar)-32.9(a)15(t)-13(hyr)-32(oid hor)]TJ 0 Tw 25.49 0 Td (-)Tj 0.17 Tw -27.286 -1.25 Td [(mone )0.6(r)-24(el)-16(a)15(ted )0.6(p)25(r)-32(o)17(tein )0.5(and )0.6(T)35(GF-be)-12(t)15(a )0.6(in )0.5(br)-24(east )0.6(cancer )0.6(p)25(r)-24(edic)-16(ts )0.6(po)-16(or )]TJ 0.134 Tw T* [(sur)-32(v)-16(i)-15.9(v)-15(al )0.5(outcome)]TJ /T1_1 1 Tf [(. )0.5(BMC )0.5(Cancer)]TJ /T1_0 1 Tf [(. )0.5(2015;15:925. )0.5(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw 20.658 0 Td (10.1186/s12885-)Tj -20.658 -1.25 Td (015-1873-x)Tj 0 0 0 1 k /GS1 gs 0.017 Tw T* (20.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(W)16(u)]TJ /Span<>> BDC ( )Tj EMC 1.456 0 Td [(CE, )0.5(W)12(ang)]TJ /Span<>> BDC ( )Tj EMC [(CW, )0.5(Huang)]TJ /Span<>> BDC ( )Tj EMC [(WK, )0.5(e)-12(t)]TJ /Span<>> BDC ( )Tj EMC 11.011 0 Td [(al. )0.5(Cy)-16(t)17(opl)-16(as)26(mic )0.5(and nuclear )0.5(p)32(ar)-33(a)]TJ 0 Tw (-)Tj 0.014 Tw -14.263 -1.25 Td [(t)-13(hyr)-32(oid )0.5(hor)-16(mone-r)-24(el)-15.9(a)15(ted p)25(r)-32(o)17(teins ar)-23.9(e opposing p)25(r)-32(o)-16(gnost)-31.9(ic f)16(a)-17(c)-16(t)17(or)-10(s in )]TJ 0.066 Tw T* [(p)32(a)15(t)-32(ients )0.5(wi)-24(t)-12.9(h non-s)26.1(mall-cell )0.5(l)35(ung )0.5(cancer )0.5(who )0.5(have )0.5(under)-32(gone )0.5(cur)-33(a)]TJ 0 Tw (-)Tj 0.1 Tw T* [(t)-32(i)-16(ve r)-24(esec)-15.9(t)-32(ion. )]TJ /T1_1 1 Tf (Jpn J Clin Oncol.)Tj /T1_0 1 Tf [( 2015;45\(3\):267\22673. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1093/)Tj T* (jjco/hyu202)Tj 0 0 0 1 k /GS1 gs 0.006 Tc 0.35 Tw T* (21.)Tj /Span<>> BDC ( )Tj EMC 1.82 0 Td (Zhao)Tj /Span<>> BDC ( )Tj EMC 2.538 0 Td [(Y, )0.5(Su)]TJ /Span<>> BDC ( )Tj EMC 2.848 0 Td [(S, )0.5(L)-32(i)]TJ /Span<>> BDC ( )Tj EMC 2.604 0 Td [(X. )0.5(P)40(ar)-33(a)15(t)-13(hyr)-32(oid )0.5(Hor)-16(mone-R)13(el)-16(a)15(ted )0.5(P)35(r)-32(o)17(tein/)]TJ 0 Tc 0.017 Tw -9.81 -1.25 Td [(P)40(ar)-33(a)15(t)-12.9(hyr)-32(oid Hor)-16(mone R)12.9(ecept)17.1(or 1 S)-16(ignal)-31(ing in Cancer and Me)-12(t)15(ast)15.1(asis. )]TJ /T1_1 1 Tf 0.023 Tw T* (Cancers \(Basel\). )Tj /T1_0 1 Tf [(2023;15\(7\):1982. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw [(10.3390/cancer)-9.9(s15071982)]TJ 0 0 0 1 k /GS1 gs 0.313 Tw T* (22.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Bur)-22(t)-31.9(is)]TJ /Span<>> BDC ( )Tj EMC [(W)31(J, W)16(u)]TJ /Span<>> BDC ( )Tj EMC (T, Bunch)Tj /Span<>> BDC ( )Tj EMC [(C, e)-11.9(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Ident)-31.9(if)-28(ica)15(t)-32(ion of a novel )]TJ 0.146 Tw -1.796 -1.25 Td [(17,000-d)42(al)56(t)17(on p)32(ar)-32.9(a)14.9(t)-12.9(hyr)-32(oid hor)-16(mone-l)-30.9(ik)10(e adenyl)-16(a)15(tecycl)-15.9(ase-st)-32(imul)-15.9(a)15(t)]TJ 0 Tw (-)Tj 0.098 Tw T* [(ing p)24.9(r)-31.9(o)17(tein fr)-32(om a tumor asso)-16(c)-24(ia)15.1(ted wi)-24(t)-13(h humor)-33(alhyper)-31.9(cal)16(cemia of )]TJ 0 Tw T* [(mal)-31(ignancy)]TJ /T1_1 1 Tf 0.023 Tw (. J Biol Chem)Tj /T1_0 1 Tf (. 1987;262\(15\):7151\2266.)Tj 0.108 Tw T* (23.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(M)-24(osele)-10.9(y)]TJ /Span<>> BDC ( )Tj EMC [(JM, K)25.1(ubo)17(t)15(a)]TJ /Span<>> BDC ( )Tj EMC [(M, Diefenba)-16.9(ch-Ja)-17(gger)]TJ /Span<>> BDC ( )Tj EMC [(H, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. P)40(ar)-33(a)15(t)-12.9(hyr)-32(oid )]TJ 0.243 Tw -1.796 -1.25 Td [(hor)-16(mone-r)-23.9(el)-16(a)15(ted p)25(r)-31.9(o)17(tein pur)-37(if)-27.9(ied fr)-32(om a human l)35(ung cancer cell )]TJ 0 Tw T* [(l)-31(ine. )]TJ /T1_1 1 Tf 0.104 Tw 2.187 0 Td [(Proc )0.6(N)18(atl )0.6(AcadSci )0.6(U )0.6(S )0.5(A)]TJ /T1_0 1 Tf [(. )0.6(1987;84\(14\):5048\22652. )0.6(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw 21.711 0 Td (10.1073/)Tj -23.899 -1.25 Td (pnas.84.14.5048)Tj 0 0 0 1 k /GS1 gs 0.024 Tw T* (24.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(S)15(tr)-24(ewler)]TJ /Span<>> BDC ( )Tj EMC 3.533 0 Td [(GJ, )0.6(S)15(ter)-15(n)]TJ /Span<>> BDC ( )Tj EMC 3.802 0 Td [(PH, )0.6(Ja)-17(cobs)]TJ /Span<>> BDC ( )Tj EMC 4.577 0 Td [(JW, )0.6(e)-12(t)]TJ /Span<>> BDC ( )Tj EMC 2.684 0 Td [(al. )0.5(P)40.1(ar)-33(a)15(t)-13(hyr)-32(oid )0.6(hor)-16(monel)-31(ik)10(e )]TJ 0.018 Tw -16.392 -1.25 Td [(p)25(r)-32(o)17(tein fr)-32(om human r)-24(enal car)-31.9(c)-24(inoma cells. S)15(tr)-22(uc)-16(tur)-32.9(al and func)-16(t)-32(ional )]TJ -0.031 Tw T* [(homol)30(o)-16(g)16(y wi)-24(t)-12.9(h p)32(ar)-33(a)15(t)-13(hyr)-32(oid hor)-16(mone. )]TJ /T1_1 1 Tf [(J Clin In)11(v)13(est)]TJ /T1_0 1 Tf (. 1987;80\(6\):1803\226)Tj 0.023 Tw T* [(7. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1172/JCI113275)Tj 0 0 0 1 k /GS1 gs 0.306 Tw T* (25.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(S)-16(ok)-16(i)]TJ /Span<>> BDC ( )Tj EMC [(FN, P)40(ar)-24(k)]TJ /Span<>> BDC ( )Tj EMC [(SI, McCaule)-10.9(y)]TJ /Span<>> BDC ( )Tj EMC [(LK. T)47(he mul)56.1(t)-32(if)16(a)-17(ce)-12(ted a)-17(c)-16(t)-31.9(ions of )]TJ 0.01 Tc 0.357 Tw -1.796 -1.25 Td [(P)0.5(TH)0.5(r)0.5(P i)0.5(n sk)10.5(el)0.5(e)-11.5(t)15.5(al)0.5( m)0.5(e)-11.5(t)15.4(a)0.5(st)15.5(a)0.5(si)0.5(s.)0.5( )]TJ /T1_1 1 Tf [(F)24.4(u)0.5(tu)0.5(r)0.5(e O)0.5(nc)0.5(o)0.5(l)]TJ /T1_0 1 Tf [(.)0.5( 2)0.5(0)0.5(12)0.5(;8)0.5(\(7)0.5(\))0.5(:8)0.5(03)0.5(\2261)0.5(7.)10( )]TJ 0 Tc 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.2217/fon.12.76)Tj 0 0 0 1 k /GS1 gs 0.188 Tw -1.847 -1.25 Td (26.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(McCaule)-10.9(y)]TJ /Span<>> BDC ( )Tj EMC [(LK, Mar)-22(t)-32(in)]TJ /Span<>> BDC ( )Tj EMC [(T)25(J. T)60(went)-10(y-f)-28(i)-16(ve year)-10(s of PTHrP p)25(r)-31.9(o)-16(gr)-24(ess: )]TJ 0.043 Tw -1.796 -1.25 Td [(fr)-32(om cancer hor)-16(mone t)17(o mul)56.1(t)-32(ifunc)-16(t)-32(ional cy)-16(t)17(ok)-16(ine. )]TJ /T1_1 1 Tf [(J Bone Miner R)21(es. )]TJ /T1_0 1 Tf 0.023 Tw T* [(2012;27\(6\):1231\2269. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1002/jbmr.1617)Tj 0 0 0 1 k /GS1 gs 0.007 Tc 0.35 Tw T* (27.)Tj /Span<>> BDC ( )Tj EMC 1.825 0 Td [(L)34.7(up)31.7(ar)-24.3(ell)29.8(o)]TJ /Span<>> BDC ( )Tj EMC [(C. P)39.7(ar)-33.3(a)14.8(t)-13.3(hyr)-32.2(oid Hor)-16.3(mone-R)12.8(el)-16.2(a)14.7(ted P)34.8(r)-32.3(o)16.8(tein \(PTHrP\):)7( )]TJ 0.009 Tc 0.349 Tw -1.825 -1.25 Td [(A K)25.1(e)-10.9(y R)13.1(egul)-16(a)15.1(t)17.1(or of L)-32(ife/Dea)15.1(t)-13(h Dec)-23.9(isions b)12.1(y T)60.1(umor Cells wi)-23.9(t)-13(h)9.1( )]TJ 0 Tc 0.004 Tw T* [(P)10(o)17(tent)-32(ial Cl)-30.9(inical Appl)-31(ica)15(t)-32(ions. )]TJ /T1_1 1 Tf (Cancers \(Basel\).)Tj /T1_0 1 Tf ( 2011;3\(1\):396\226407. )Tj 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td [(10.3390/cancer)-9.9(s3010396)]TJ 0 0 0 1 k /GS1 gs -0.064 Tw -1.847 -1.25 Td (28.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Naafs)Tj /Span<>> BDC ( )Tj EMC [(MA)44(B. P)40(ar)-33(a)15(t)-13(hyr)-31.9(oid hor)-16(mone r)-24(el)-15.9(a)15(ted pept)-32(ide \(PTHrP\): a mini-)]TJ 0 Tw -1.796 -1.25 Td [(r)-24(ev)-15.9(iew. )]TJ /T1_1 1 Tf 0.082 Tw 3.252 0 Td [(Endocr)-36.9(inol )0.5(Metab )0.6(Int)]TJ /Span<>> BDC ( )Tj EMC 8.679 0 Td (J)Tj /T1_0 1 Tf [(. )0.6(2017;5\(6\):321\226328. )0.6(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw 11.467 0 Td (10.15406/)Tj -23.399 -1.25 Td (emij.2017.05.00139)Tj 0 0 0 1 k /GS1 gs 0.211 Tw T* (29.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Zhao)Tj /Span<>> BDC ( )Tj EMC 2.37 0 Td [(LH, )0.5(Ma)]TJ /Span<>> BDC ( )Tj EMC 3.257 0 Td [(S, )0.5(Sutk)10(ev)-16(ic)-23.9(iute)]TJ /Span<>> BDC ( )Tj EMC 6.588 0 Td [(I, )0.5(e)-12(t)]TJ /Span<>> BDC ( )Tj EMC 2.277 0 Td [(al. )0.5(S)15(tr)-22(uc)-15.9(tur)-24(e )0.5(and )0.5(d)17(ynamics )]TJ 0.003 Tc 0.35 Tw -16.287 -1.25 Td [(of t)-13.2(he a)-17.2(c)-16.1(t)-32.2(i)-16.1(ve human p)31.9(ar)-33.1(a)14.8(t)-13.1(hyr)-32.2(oid hor)-16.1(mone r)-24.1(ecept)16.9(or-1. )]TJ /T1_1 1 Tf -0.003 Tw (Science)Tj /T1_0 1 Tf 0 Tc 0 Tw (. )Tj 0.023 Tw T* [(2019;364\(6436\):148\226153. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw [(10.1126/sc)-24(ience.aav7942)]TJ 0 0 0 1 k /GS1 gs 0.136 Tw T* (30.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Mal)-16(akout)-31.9(i)]TJ /Span<>> BDC ( )Tj EMC (S, Asadi)Tj /Span<>> BDC ( )Tj EMC [(FK, K)25(ukr)-24(eja)]TJ /Span<>> BDC ( )Tj EMC [(SC, e)-11.9(t)]TJ /Span<>> BDC ( )Tj EMC [(al. P)40(ar)-33(a)15(t)-13(hyr)-31.9(oid hor)-15.9(mone-)]TJ 0.072 Tw -1.796 -1.25 Td [(r)-24(el)-16(a)15.1(ted p)25(r)-32(o)17(tein e)-18(xp)25(r)-24(ession in t)-13(he human col)30(on: immunohist)17.1(o)-16(chemi)]TJ 0 Tw (-)Tj 0.023 Tw T* [(cal ev)-15(al)35(ua)15.1(t)-32(ion. )]TJ /T1_1 1 Tf (Am Surg.)Tj /T1_0 1 Tf ( 1996;62\(7\):540\2264; discussion 544-5.)Tj 0.009 Tw T* (31.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Nishihar)-32.9(a)]TJ /Span<>> BDC ( )Tj EMC [(M, It)17.1(o)]TJ /Span<>> BDC ( )Tj EMC [(M, T)45(omiok)-17(a)]TJ /Span<>> BDC ( )Tj EMC 11.312 0 Td [(T, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC 1.96 0 Td [(al. Cl)-30.9(inicop)32(a)15(t)-13(hol)30(o)-16(gical )0.5(im)10(pl)-31(ica)]TJ 0 Tw (-)Tj 0.176 Tw -15.068 -1.25 Td [(t)-32(ions of p)32(ar)-33(a)15(t)-12.9(hyr)-32(oid hor)-16(mone-r)-24(el)-15.9(a)15(ted p)25(r)-32(o)17(tein in human col)30(or)-24(ec)-16(t)15(al )]TJ 0 Tw T* [(tumour)-9.9(s. )]TJ /T1_1 1 Tf 0.154 Tw 4.006 0 Td [(J P)18(athol.)]TJ /T1_0 1 Tf [( 1999;187\(2\):217\22622. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1002/\(SICI\)1096-)Tj -4.006 -1.25 Td [(9896\(199901\)187:2<217:AID-P)25.1(A)15(TH210>3.0.C)13(O;2-0)]TJ 0 0 0 1 k /GS1 gs 0.139 Tw T* (32.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(W)12(a)15(tson)]TJ /Span<>> BDC ( )Tj EMC [(PH, F)10(r)-33(aher)]TJ /Span<>> BDC ( )Tj EMC [(LJ, )0.5(Hend)17(y)]TJ /Span<>> BDC ( )Tj EMC [(GN, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Nuclear )0.5(l)30(o)-16(cal)-31(iza)15(t)-31.9(ion of )]TJ 0.22 Tw -1.796 -1.25 Td [(t)-13(he t)-10(ype 1 PTH/PTHrP r)-24(ecept)17(or in r)-33(a)15(t t)-32(issues. )]TJ /T1_1 1 Tf [(J Bone Miner R)21(es. )]TJ /T1_0 1 Tf 0.023 Tw T* [(2000;15\(6\):1033\22644. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1359/jbmr.2000.15.6.1033)Tj 0 0 0 1 k /GS1 gs 0.321 Tw T* (33.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Ga)-17(giannis)]TJ /Span<>> BDC ( )Tj EMC (S, M\374ller)Tj /Span<>> BDC ( )Tj EMC (M, Uhlemann)Tj /Span<>> BDC ( )Tj EMC [(S, e)-11.9(t)]TJ /Span<>> BDC ( )Tj EMC [(al. P)40(ar)-33(a)15(t)-12.9(hyr)-32(oid hor)]TJ 0 Tw 25.49 0 Td (-)Tj 0.255 Tw -27.286 -1.25 Td [(mone-r)-23.9(el)-16(a)15(ted p)25(r)-32(o)17(tein confer)-9.9(s chemor)-23.9(esist)15(ance b)12(y bl)30(o)-16(ck)-15.9(ing apop)]TJ 0 Tw (-)Tj 0.107 Tw T* [(t)17(osis )0.6(signal)-31(ing )0.5(v)-15.9(ia )0.5(dea)15(t)-13(h )0.6(r)-24(ecept)17(or)-10(s )0.6(and )0.5(mi)-24(t)17(o)-16(chondr)-36.9(ia. )]TJ /T1_1 1 Tf 22.49 0 Td [(Int )0.5(J )0.6(Cancer)]TJ /T1_0 1 Tf 0 Tw (. )Tj 0.023 Tw -22.49 -1.25 Td [(2009;125\(7\):1551\2267. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1002/ijc.24471)Tj 0 0 0 1 k /GS1 gs 0.051 Tw T* (34.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Bha)15(t)-32(ia)]TJ /Span<>> BDC ( )Tj EMC (V, Saini)Tj /Span<>> BDC ( )Tj EMC [(MK, F)20(al)-40(zon)]TJ /Span<>> BDC ( )Tj EMC [(M. Nuclear PTHrP t)15(ar)-31.9(ge)-12(t)-32(ing r)-24(egul)-16(a)15(tes )]TJ 0.082 Tw -1.796 -1.25 Td [(PTHrP secr)-23.9(e)-12(t)-32(ion and enhances L)35(oV)29(o cell gr)-31.9(o)-14(w)-24(t)-13(h and sur)-32(v)-16(i)-15.9(v)-15(al. )]TJ /T1_1 1 Tf 0 Tw [(R)21(egul )]TJ T* [(P)15(ep)13(t. )]TJ /T1_0 1 Tf 0.023 Tw 2.297 0 Td [(2009; 158\(1-3\):149\22655. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw [(10.1016/j.r)-23.9(egpep.2009.07.008)]TJ 0 0 0 1 k /GS1 gs 0.149 Tw 26.758 81.25 Td (35.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Ahmed)Tj /Span<>> BDC ( )Tj EMC (D, Eide)Tj /Span<>> BDC ( )Tj EMC [(PW, Eiler)-21.9(tsen)]TJ /Span<>> BDC ( )Tj EMC [(IA, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Epigene)-11.9(t)-32(ic and gene)-12(t)-32(ic )]TJ 0.126 Tw -1.796 -1.25 Td [(fea)15(tur)-23.9(es of 24 col)30(on cancer cell l)-30.9(ines. )]TJ /T1_1 1 Tf 0 Tw [(Oncog)12(enesis)]TJ /T1_0 1 Tf 0.126 Tw (. 2013;2\(9\):e71. )Tj 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1038/oncsis.2013.35)Tj 0 0 0 1 k /GS1 gs 0.002 Tc 0.35 Tw -1.847 -1.25 Td (36.)Tj /Span<>> BDC ( )Tj EMC 1.804 0 Td [(S)-16(hen)]TJ /Span<>> BDC ( )Tj EMC 2.577 0 Td [(X, )0.5(Mul)-16.1(a)]TJ /Span<>> BDC ( )Tj EMC 3.77 0 Td [(RV, )0.5(Ever)-10.1(s)]TJ /Span<>> BDC ( )Tj EMC [(BM, )0.5(e)-12.1(t)]TJ /Span<>> BDC ( )Tj EMC 7.914 0 Td [(al. Incr)-24.1(eased cell )0.5(sur)-32(v)-16.1(i)-16(v)-15.1(al,)2( )]TJ 0 Tc 0.29 Tw -16.065 -1.25 Td [(migr)-33(a)15(t)-31.9(ion, inv)-14.9(asion, and Ak)-24(t e)-18(xp)25(r)-23.9(ession in PTHrP-over)-23.9(e)-18(xp)25(r)-24(essing )]TJ 0.268 Tw T* [(L)35(oV)29(o col)30.1(on cancer cell l)-31(ines)]TJ /T1_1 1 Tf [(. R)21(egul P)15(ep)13(t)]TJ /T1_0 1 Tf (. 2007; 141\(1-3\):61\22672. )Tj 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td [(10.1016/j.r)-23.9(egpep.2006.12.017)]TJ 0 0 0 1 k /GS1 gs 0.306 Tw -1.847 -1.25 Td (37.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Mul)-16(a)]TJ /Span<>> BDC ( )Tj EMC 2.461 0 Td [(RV, )0.6(Bha)15(t)-32(ia)]TJ /Span<>> BDC ( )Tj EMC 4.928 0 Td [(V, )0.6(F)19.9(al)-39.9(zon)]TJ /Span<>> BDC ( )Tj EMC 4.368 0 Td [(M. )0.6(PTHrP )0.6(p)25(r)-32(omo)17(tes )0.5(col)30.1(on )0.5(cancer )]TJ 0.195 Tw -13.553 -1.25 Td [(cell migr)-33(a)15(t)-32(ion and inv)-14.9(asion in an integr)-36.9(in \2636\2564-dependent man)]TJ 0 Tw (-)Tj 0.154 Tw T* [(ner )0.6(t)-13(hr)-32(ough )0.6(a)-17(c)-16(t)-32(i)-16(v)-14.9(a)15(t)-32(ion )0.5(of )0.6(R)-10(a)-17(c1. )]TJ /T1_1 1 Tf 13.767 0 Td [(Cancer )0.6(Lett.)]TJ /T1_0 1 Tf [( )0.6(2010;298\(1\):119\22627. )]TJ 0 Tw -13.767 -1.25 Td [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td [(10.1016/j.canle)-11.9(t.2010.06.009)]TJ 0 0 0 1 k /GS1 gs 0.038 Tw -1.847 -1.25 Td (38.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Bo)17(tchk)-16(ina)]TJ /Span<>> BDC ( )Tj EMC [(IL, R)11(o)-14(wehl)]TJ /Span<>> BDC ( )Tj EMC [(RA, R)-24(i)-16(v)-15(adeneir)-33(a)]TJ /Span<>> BDC ( )Tj EMC [(DE, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Pheno)17(t)-10(ypic sub)]TJ 0 Tw (-)Tj 0.013 Tw -1.796 -1.25 Td [(popul)-16(a)15(t)-32(ions of me)-12(t)15(ast)15(a)15(t)-31.9(ic col)30(on cancer stem cells: genomic anal)35(y)-12.9(sis. )]TJ /T1_1 1 Tf 0.023 Tw T* [(Cancer Genomics Pro)13(teomics)]TJ /T1_0 1 Tf (. 2009;6\(1\):19\22629.)Tj 0.054 Tw T* (39.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Cal)30(vo)]TJ /Span<>> BDC ( )Tj EMC [(N, Mar)-22(t\355n)]TJ /Span<>> BDC ( )Tj EMC [(MJ, de Bol)-16(and)]TJ /Span<>> BDC ( )Tj EMC [(AR, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Invol)30(vement of ERK1/2, )]TJ 0.007 Tw -1.796 -1.25 Td [(p38 MAPK, and PI3K/Ak)-23.9(t signal)-31(ing p)32(a)15(t)-13(hw)-12(a)15(y)-12.9(s in t)-12.9(he r)-23.9(egul)-16(a)15(t)-32(ion of cell )]TJ 0.073 Tw T* [(cycle )0.5(p)25(r)-32(o)-16(gr)-23.9(ession )0.5(b)12(y PTHrP )0.6(in col)30.1(on )0.5(adeno)-16(car)-32(c)-24(inoma )0.5(cells. )]TJ /T1_1 1 Tf 0 Tw 24.298 0 Td (Biochem )Tj 0.023 Tw -24.298 -1.25 Td (Cell Biol)Tj /T1_0 1 Tf [(. 2014;92\(4\):305\22615. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1139/bcb-2013-0106)Tj 0 0 0 1 k /GS1 gs -0.022 Tw T* (40.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(L)35(ezcano)]TJ /Span<>> BDC ( )Tj EMC [(V, Gent)-31.9(il)-31(i)]TJ /Span<>> BDC ( )Tj EMC [(C, de Bol)-16(and)]TJ /Span<>> BDC ( )Tj EMC 12.339 0 Td [(AR. R)11(ole of )0.5(PTHrP in human )0.5(intes)]TJ 0 Tw (-)Tj 0.056 Tw -14.135 -1.25 Td [(t)-32(inal Ca)-17(co-2 cell r)-24(esponse t)17(o o)13.9(xid)42.1(a)15(t)-32(i)-16(ve str)-24(ess. )]TJ /T1_1 1 Tf [(Biochim Bioph)12(ys Acta.)]TJ /T1_0 1 Tf 0 Tw ( )Tj 0.017 Tw T* [(2013 Dec;1833\(12\):2834\2262843. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1016/j.bbamcr.2013.06.029)Tj 0 0 0 1 k /GS1 gs 0.103 Tw T* (41.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Mar)-22(t\355n)]TJ /Span<>> BDC ( )Tj EMC [(MJ, Cal)30.1(vo)]TJ /Span<>> BDC ( )Tj EMC [(N, de Bol)-15.9(and)]TJ /Span<>> BDC ( )Tj EMC [(AR, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. M)-24(olecul)-16(ar mechanis)26.1(ms )]TJ 0.047 Tw -1.796 -1.25 Td [(asso)-16(c)-24(ia)15.1(ted wi)-23.9(t)-13(h PTHrP-induced p)25(r)-32(ol)-31(ifer)-32.9(a)15(t)-32(ion of col)30(on cancer cells. )]TJ /T1_1 1 Tf 0 Tw (J )Tj 0.023 Tw T* (Cell Biochem)Tj /T1_0 1 Tf [(. 2014;115\(12\):2133\22645. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1002/jcb.24890)Tj 0 0 0 1 k /GS1 gs -0.001 Tw T* (42.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Cal)30(vo)]TJ /Span<>> BDC ( )Tj EMC [(N, Car)-24(r)-37(ier)-23.9(e)]TJ /Span<>> BDC ( )Tj EMC [(P, Mar)-22(t)-32(in)]TJ /Span<>> BDC ( )Tj EMC [(MJ, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. RSK a)-17(c)-16(t)-32(i)-16(v)-15(a)15(t)-31.9(ion v)-16(ia ERK mod)]TJ 0 Tw (-)Tj 0.008 Tw -1.796 -1.25 Td [(ul)-16(a)15(tes human col)30(on cancer cells r)-23.9(esponse t)17.1(o PTHrP. )]TJ /T1_1 1 Tf [(J Mol Endocr)-37(inol)]TJ /T1_0 1 Tf 0 Tw (. )Tj 0.023 Tw T* [(2017;59\(1\):13\22627. d)-15.9(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1530/JME-16-0216)Tj 0 0 0 1 k /GS1 gs 0.055 Tw T* (43.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Mar)-22(t\355n)]TJ /Span<>> BDC ( )Tj EMC [(MJ, Gigol)-15.9(a)]TJ /Span<>> BDC ( )Tj EMC [(G, Z)66(wenger)]TJ /Span<>> BDC ( )Tj EMC [(A, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. P)10(o)17(tent)-32(ial t)-13(her)-32.9(apeut)-32(ic t)15(ar)]TJ 0 Tw 25.49 0 Td (-)Tj -0.044 Tw -27.286 -1.25 Td [(ge)-12(ts for gr)-32(o)-14(w)-23.9(t)-13(h ar)-24(r)-24(est of col)30.1(or)-24(ec)-16(t)15(al cancer cells e)-17.9(xposed t)17(o PTHrP. )]TJ /T1_1 1 Tf 0 Tw (Mol )Tj 0.023 Tw T* [(Cell Endocr)-36.9(inol)]TJ /T1_0 1 Tf [(. 2018;478:32\22644. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1016/j.mce.2018.07.005)Tj 0 0 0 1 k /GS1 gs 0.171 Tw T* (44.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(N)-14(ovoa D\355a)-24(z)]TJ /Span<>> BDC ( )Tj EMC [(MB, Car)-23.9(r)-37(ier)-24(e)]TJ /Span<>> BDC ( )Tj EMC [(PM, Mar)-21.9(t\355n)]TJ /Span<>> BDC ( )Tj EMC [(MJ, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Invol)30(vement of )]TJ 0.169 Tw -1.796 -1.25 Td [(p)32(ar)-33(a)15(t)-13(hyr)-31.9(oid hor)-15.9(mone-r)-24(el)-16(a)15(ted pept)-32(ide in t)-13(he a)-17(ggr)-24(essi)-15.9(ve pheno)17(t)-10(ype )]TJ 0.055 Tw T* [(of col)30(or)-24(ec)-16(t)15.1(al cancer cells. )]TJ /T1_1 1 Tf [(W)28.9(orld J Gastroenterol)]TJ /T1_0 1 Tf (. 2021;27\(41\):7025\226)Tj 0.023 Tw T* [(7040. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.3748/wjg.v27.i41.7025)Tj 0 0 0 1 k /GS1 gs 0.104 Tw T* (45.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(K)25(ong)]TJ /Span<>> BDC ( )Tj EMC (DH, Kim)Tj /Span<>> BDC ( )Tj EMC (MR, Jang)Tj /Span<>> BDC ( )Tj EMC [(JH, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. A R)13(ev)-16(iew of Ant)-31.9(i-Angio)-16(genic )]TJ 0.293 Tw -1.796 -1.25 Td [(T)40(ar)-32(ge)-12(ts for M)-24(ono)-15.9(cl)30(onal Ant)-32(ibod)17(y Cancer T)47(her)-33(apy. )]TJ /T1_1 1 Tf (Int J Mol Sci)Tj /T1_0 1 Tf 0 Tw (. )Tj 0.023 Tw T* [(2017;18\(8\):1786. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.3390/ijms18081786)Tj 0 0 0 1 k /GS1 gs 0.101 Tw T* (46.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Ba)15(t)-30(t)15(a)-17(gl)-30.9(in)]TJ /Span<>> BDC ( )Tj EMC [(F, P)20(ucc)-24(ini)]TJ /Span<>> BDC ( )Tj EMC [(A, Int)-32(ini)]TJ /Span<>> BDC ( )Tj EMC [(R, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. T)47(he r)-32(ole of tumor angio)]TJ 0 Tw (-)Tj 0.271 Tw -1.796 -1.25 Td [(genesis )0.6(as )0.5(a )0.5(t)-12.9(her)-33(apeut)-32(ic )0.6(t)15(ar)-32(ge)-12(t )0.6(in )0.5(col)30(or)-24(ec)-16(t)15(al )0.5(cancer. )]TJ /T1_1 1 Tf 23.295 0 Td [(Exper)-40(t )0.6(R)21(ev )]TJ 0.188 Tw -23.295 -1.25 Td (Anticancer Ther. )Tj /T1_0 1 Tf [(2018;18\(3\):251\226266. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1080/14737140.201)Tj T* (8.1428092)Tj 0 0 0 1 k /GS1 gs 0.004 Tc 0.35 Tw T* (47.)Tj /Span<>> BDC ( )Tj EMC 1.813 0 Td [(Cal)29.6(vo)]TJ /Span<>> BDC ( )Tj EMC [(N, Car)-24.3(r)-37.3(ier)-24.4(e)]TJ /Span<>> BDC ( )Tj EMC [(P, Mar)-22.3(t\355n)]TJ /Span<>> BDC ( )Tj EMC [(MJ, e)-12.3(t)]TJ /Span<>> BDC ( )Tj EMC [(al. PTHrP tr)-24.4(ea)14.6(tment of)4( )]TJ 0 Tc 0.149 Tw -1.813 -1.25 Td [(col)30(on cancer cells p)25(r)-32(omo)17(tes tumor asso)-16(c)-24(ia)15(ted-angio)-15.9(genesis b)12(y t)-13(he )]TJ 0.023 Tw T* [(ef)-56(fec)-16(t )0.5(of )0.5(VEGF. )]TJ /T1_1 1 Tf 6.248 0 Td [(Mol )0.5(Cell )0.5(Endocr)-36.9(inol)]TJ /T1_0 1 Tf [(. )0.5(2019;483:50\22663. )0.5(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw 17.075 0 Td (10.1016/j.)Tj -23.324 -1.25 Td (mce.2019.01.005)Tj 0 0 0 1 k /GS1 gs 0.192 Tw T* (48.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(T)60(soumas)]TJ /Span<>> BDC ( )Tj EMC (D, Nikou)Tj /Span<>> BDC ( )Tj EMC [(S, Giannopoul)30.1(ou)]TJ /Span<>> BDC ( )Tj EMC [(E, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. ILK E)35(xp)25.1(r)-24(ession in )]TJ 0.104 Tw -1.796 -1.25 Td [(Col)30(or)-23.9(ec)-16(t)15(al Cancer Is Asso)-16(c)-24(ia)15(ted wi)-24(t)-13(h EMT, Cancer S)15(tem Cell Mar)-24(k)10(er)-10(s )]TJ 0.038 Tw T* [(and Chemor)-24(esist)15.1(ance. )]TJ /T1_1 1 Tf [(Cancer Genomics Pro)13(teomics.)]TJ /T1_0 1 Tf ( 2018;15\(2\):127\226)Tj 0.023 Tw T* [(141. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.21873/cgp.20071)Tj 0 0 0 1 k /GS1 gs -0.009 Tw T* (49.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(P)40(ar)-10(sons)]TJ /Span<>> BDC ( )Tj EMC [(S, Mald)-16(onad)-15.9(o)]TJ /Span<>> BDC ( )Tj EMC [(EB, P)35(r)-33(asad)]TJ /Span<>> BDC ( )Tj EMC [(V. Com)10(p)32(ar)-37(ison of Dr)-22(ugs Used for )]TJ 0.005 Tw -1.796 -1.25 Td [(A)15(d)17(juv)-15(ant )0.6(and )0.6(Me)-12(t)15(ast)15(a)15(t)-32(ic )0.6(T)47(her)-33(apy )0.5(of )0.6(Col)30(on, )0.6(Br)-24(east, )0.6(and )0.5(N)-14(on-Small )0.6(Cell )]TJ 0.132 Tw T* [(L)35(ung Cancer)-10(s. )]TJ /T1_1 1 Tf [(J)30(AMA N)18(etw Open.)]TJ /T1_0 1 Tf [( 2020;3\(4\):e202488. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1001/)Tj T* [(jamane)-12(t)-32(w)-13.9(or)-24(kopen.2020.2488)]TJ 0 0 0 1 k /GS1 gs 0.264 Tw T* (50.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Gugl)-31(ielmi)]TJ /Span<>> BDC ( )Tj EMC [(AP, S)-15.9(obr)-24(er)-32(o)]TJ /Span<>> BDC ( )Tj EMC [(AF. Second-l)-31(ine t)-13(her)-32.9(apy for ad)-17(v)-15(anced )]TJ 0.023 Tw -1.796 -1.25 Td [(col)30(or)-24(ec)-15.9(t)15(al cancer. )]TJ /T1_1 1 Tf [(Gastrointest Cancer R)21(es)]TJ /T1_0 1 Tf (. 2007;1\(2\):57\22663.)Tj 0.312 Tw T* (51.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(M)-24(o)-16(cell)-30.9(in)]TJ /Span<>> BDC ( )Tj EMC [(S, Bar)-24(e)-12(t)-29.9(t)15(a)]TJ /Span<>> BDC ( )Tj EMC [(Z, R)11(o)-16(qu\351)]TJ /Span<>> BDC ( )Tj EMC [(I, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Second-l)-31(ine sy)-13(stemic )]TJ -0.007 Tw -1.796 -1.25 Td [(t)-13(her)-32.9(apy for me)-12(t)15.1(ast)15(a)15(t)-32(ic col)30(or)-24(ec)-15.9(t)15(al cancer. )]TJ /T1_1 1 Tf [(Cochrane Database Syst R)21.1(ev)]TJ /T1_0 1 Tf 0 Tw (. )Tj 0.023 Tw T* [(2017;1\(1\):CD006875. d)-15.9(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1002/14651858.CD006875.pub3)Tj 0 0 0 1 k /GS1 gs -0.013 Tw T* (52.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Cui)Tj /Span<>> BDC ( )Tj EMC (Y, Sun)Tj /Span<>> BDC ( )Tj EMC (Y, Hu)Tj /Span<>> BDC ( )Tj EMC [(S, e)-11.9(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Neur)-31.9(oend)-16(o)-16(cr)-37(ine p)25(r)-32(ost)15(a)15.1(te cancer \(NEPCa\) )]TJ 0.286 Tw -1.796 -1.25 Td [(incr)-24(eased t)-13(he neighbor)-37(ing PCa chemor)-24(esist)15(ance v)-16(ia al)56(ter)-37(ing t)-13(he )]TJ 0.213 Tw T* [(PTHrP/p38/Hsp27/andr)-31.9(o)-16(gen )0.5(r)-24(ecept)17(or )0.5(\(AR\)/p21 )0.5(signals. )]TJ /T1_1 1 Tf 0 Tw 23.577 0 Td [(Oncog)12(ene)]TJ /T1_0 1 Tf (. )Tj 0.023 Tw -23.577 -1.25 Td [(2016;35\(47\):6065\2266076. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1038/onc.2016.135)Tj 0 0 0 1 k /GS1 gs 0.14 Tw T* (53.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(P)40(aill)-15.9(as)]TJ /Span<>> BDC ( )Tj EMC [(S, Boissi\350r)-23.9(e)]TJ /Span<>> BDC ( )Tj EMC (F, Bibeau)Tj /Span<>> BDC ( )Tj EMC [(F, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. T)40(ar)-32(ge)-12(t)-32(ing t)-13(he p38 MAPK )]TJ 0.266 Tw -1.796 -1.25 Td [(p)32(a)15(t)-13(hw)-12(a)15.1(y inhibi)-23.9(ts )0.5(ir)-37(ino)17(tecan )0.5(r)-24(esist)15.1(ance )0.5(in )0.5(col)30(on )0.5(adeno)-16(car)-32(c)-24(inoma. )]TJ /T1_1 1 Tf 0.279 Tw T* [(Cancer R)21(es.)]TJ /T1_0 1 Tf [( 2011;71\(3\):1041\2269. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw [(10.1158/0008-5472.C)20(A)51(N-10-)]TJ T* (2726)Tj /T1_2 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\214)10(\211\036\033 \035\030\032\t\033)30(\b)42(\032)-21(\240\033\233)]TJ 57.136 0 Td (REVIEW)Tj -57.136 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 23, \023\0221)69(, 202)69(4)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 23, \023\0221)69(, 202)69(4)]TJ /T1_3 1 Tf 25 0 0 25 20.8276 56.0378 Tm (170)Tj ET endstream endobj 334 0 obj <>/Border[0 0 0]/H/N/Rect[145.286 728.512 238.758 719.216]/Subtype/Link/Type/Annot>> endobj 335 0 obj <>/Border[0 0 0]/H/N/Rect[157.286 688.512 223.23 679.216]/Subtype/Link/Type/Annot>> endobj 336 0 obj <>/Border[0 0 0]/H/N/Rect[224.577 668.512 291.968 659.056]/Subtype/Link/Type/Annot>> endobj 337 0 obj <>/Border[0 0 0]/H/N/Rect[70.8661 658.512 85.6821 649.216]/Subtype/Link/Type/Annot>> endobj 338 0 obj <>/Border[0 0 0]/H/N/Rect[236.129 628.512 291.968 619.056]/Subtype/Link/Type/Annot>> endobj 339 0 obj <>/Border[0 0 0]/H/N/Rect[70.8661 618.512 108.05 609.216]/Subtype/Link/Type/Annot>> endobj 340 0 obj <>/Border[0 0 0]/H/N/Rect[262.057 578.512 291.968 569.056]/Subtype/Link/Type/Annot>> endobj 341 0 obj <>/Border[0 0 0]/H/N/Rect[70.8661 568.512 110.226 559.216]/Subtype/Link/Type/Annot>> endobj 342 0 obj <>/Border[0 0 0]/H/N/Rect[198.346 538.512 284.553 529.056]/Subtype/Link/Type/Annot>> endobj 343 0 obj <>/Border[0 0 0]/H/N/Rect[262.057 468.512 291.968 459.056]/Subtype/Link/Type/Annot>> endobj 344 0 obj <>/Border[0 0 0]/H/N/Rect[70.8661 458.512 124.954 449.216]/Subtype/Link/Type/Annot>> endobj 345 0 obj <>/Border[0 0 0]/H/N/Rect[94.0624 418.512 158.31 409.216]/Subtype/Link/Type/Annot>> endobj 346 0 obj <>/Border[0 0 0]/H/N/Rect[85.6442 388.512 146.964 379.216]/Subtype/Link/Type/Annot>> endobj 347 0 obj <>/Border[0 0 0]/H/N/Rect[153.286 358.512 216.086 349.216]/Subtype/Link/Type/Annot>> endobj 348 0 obj <>/Border[0 0 0]/H/N/Rect[85.6442 318.512 167.852 309.216]/Subtype/Link/Type/Annot>> endobj 349 0 obj <>/Border[0 0 0]/H/N/Rect[258.057 298.512 291.968 289.056]/Subtype/Link/Type/Annot>> endobj 350 0 obj <>/Border[0 0 0]/H/N/Rect[70.8661 288.512 135.938 279.216]/Subtype/Link/Type/Annot>> endobj 351 0 obj <>/Border[0 0 0]/H/N/Rect[173.286 258.512 256.677 249.216]/Subtype/Link/Type/Annot>> endobj 352 0 obj <>/Border[0 0 0]/H/N/Rect[223.897 198.512 291.968 189.056]/Subtype/Link/Type/Annot>> endobj 353 0 obj <>/Border[0 0 0]/H/N/Rect[70.8661 188.512 235.105 179.216]/Subtype/Link/Type/Annot>> endobj 354 0 obj <>/Border[0 0 0]/H/N/Rect[157.286 158.512 255.189 149.216]/Subtype/Link/Type/Annot>> endobj 355 0 obj <>/Border[0 0 0]/H/N/Rect[157.286 118.512 217.526 109.216]/Subtype/Link/Type/Annot>> endobj 356 0 obj <>/Border[0 0 0]/H/N/Rect[184.531 88.5119 284.362 79.0558]/Subtype/Link/Type/Annot>> endobj 357 0 obj <>/Border[0 0 0]/H/N/Rect[318.085 718.512 396.837 709.216]/Subtype/Link/Type/Annot>> endobj 358 0 obj <>/Border[0 0 0]/H/N/Rect[318.085 678.512 417.916 669.216]/Subtype/Link/Type/Annot>> endobj 359 0 obj <>/Border[0 0 0]/H/N/Rect[318.085 638.512 415.772 629.216]/Subtype/Link/Type/Annot>> endobj 360 0 obj <>/Border[0 0 0]/H/N/Rect[415.595 568.512 494.635 559.056]/Subtype/Link/Type/Annot>> endobj 361 0 obj <>/Border[0 0 0]/H/N/Rect[423.306 538.512 524.409 529.216]/Subtype/Link/Type/Annot>> endobj 362 0 obj <>/Border[0 0 0]/H/N/Rect[442.035 508.512 504.043 499.056]/Subtype/Link/Type/Annot>> endobj 363 0 obj <>/Border[0 0 0]/H/N/Rect[381.727 478.512 454.079 469.216]/Subtype/Link/Type/Annot>> endobj 364 0 obj <>/Border[0 0 0]/H/N/Rect[426.819 448.512 517.434 439.056]/Subtype/Link/Type/Annot>> endobj 365 0 obj <>/Border[0 0 0]/H/N/Rect[338.503 408.512 424.575 399.216]/Subtype/Link/Type/Annot>> endobj 366 0 obj <>/Border[0 0 0]/H/N/Rect[377.279 378.512 452.535 369.216]/Subtype/Link/Type/Annot>> endobj 367 0 obj <>/Border[0 0 0]/H/N/Rect[448.13 348.512 524.409 339.056]/Subtype/Link/Type/Annot>> endobj 368 0 obj <>/Border[0 0 0]/H/N/Rect[303.307 338.512 337.675 329.216]/Subtype/Link/Type/Annot>> endobj 369 0 obj <>/Border[0 0 0]/H/N/Rect[489.898 308.512 524.409 299.056]/Subtype/Link/Type/Annot>> endobj 370 0 obj <>/Border[0 0 0]/H/N/Rect[303.307 298.512 359.411 289.216]/Subtype/Link/Type/Annot>> endobj 371 0 obj <>/Border[0 0 0]/H/N/Rect[334.503 258.512 402.295 249.216]/Subtype/Link/Type/Annot>> endobj 372 0 obj <>/Border[0 0 0]/H/N/Rect[494.498 228.512 524.409 219.056]/Subtype/Link/Type/Annot>> endobj 373 0 obj <>/Border[0 0 0]/H/N/Rect[303.307 218.512 397.85 209.216]/Subtype/Link/Type/Annot>> endobj 374 0 obj <>/Border[0 0 0]/H/N/Rect[389.463 168.512 504.455 159.216]/Subtype/Link/Type/Annot>> endobj 375 0 obj <>/Border[0 0 0]/H/N/Rect[401.727 128.512 476.023 119.216]/Subtype/Link/Type/Annot>> endobj 376 0 obj <>/Border[0 0 0]/H/N/Rect[431.37 98.5119 524.409 89.0558]/Subtype/Link/Type/Annot>> endobj 377 0 obj <>/Border[0 0 0]/H/N/Rect[303.307 88.5119 319.307 79.2159]/Subtype/Link/Type/Annot>> endobj 421 0 obj <> endobj 420 0 obj <> endobj 419 0 obj <> endobj 418 0 obj <> endobj 417 0 obj <> endobj 416 0 obj <> endobj 415 0 obj <> endobj 414 0 obj <> endobj 413 0 obj <> endobj 412 0 obj <> endobj 411 0 obj <> endobj 410 0 obj <> endobj 409 0 obj <> endobj 408 0 obj <> endobj 407 0 obj <> endobj 406 0 obj <> endobj 405 0 obj <> endobj 404 0 obj <> endobj 403 0 obj <> endobj 402 0 obj <> endobj 401 0 obj <> endobj 400 0 obj <> endobj 399 0 obj <> endobj 398 0 obj <> endobj 397 0 obj <3.0.CO;2-0)>> endobj 396 0 obj <3.0.CO;2-0)>> endobj 395 0 obj <> endobj 394 0 obj <> endobj 393 0 obj <> endobj 392 0 obj <> endobj 391 0 obj <> endobj 390 0 obj <> endobj 389 0 obj <> endobj 388 0 obj <> endobj 387 0 obj <> endobj 386 0 obj <> endobj 385 0 obj <> endobj 384 0 obj <> endobj 383 0 obj <> endobj 382 0 obj <> endobj 381 0 obj <> endobj 380 0 obj <> endobj 379 0 obj <> endobj 378 0 obj <> endobj 330 0 obj [422 0 R 423 0 R 424 0 R 425 0 R 426 0 R 427 0 R 428 0 R 429 0 R 430 0 R 431 0 R 432 0 R 433 0 R 434 0 R 435 0 R 436 0 R 437 0 R 438 0 R] endobj 331 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\037)31(\025\007\025\002\016\n)-10(\026)11(\013\007\216\001\020\203 \002\013\n, \013\006\006\025\227\220\220\002\025\ \r\013\001\001\020\203 \006\022\221\013\002\013\026\202)10(\025\002\024\025\001-)]TJ 0 -1 TD [(\002\025\201\006)-10(\026\r\016\001\001\020\024 \221\002\025\026)11(\016\220\001\025\024 \(\025\f\222\025\002 \007\220\026)11(\016\002\013\026)-19.9(\215\002\020\))]TJ 42.257 1 Td [(Color)31(ectal cancer associated with par)21(ath)31(yr)20(oid )]TJ 4.983 -1 Td [(h)11(ormone)-52(-r)31.1(elated pr)20(otein \(r)31(e)11(vie)11(w\))]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0.143 Tw 10 0 0 10 42.5197 724.8299 Tm (\235\036\027\024\021\017\023\026, \017)Tj /Span<>> BDC ( )Tj EMC (\024\023\017\f\026\027\t \n\024\035\036\022\031\035\016\030\027\t\036 \n\ \036\b\026\027\017\n\t, \026)Tj 0 Tw (-)Tj 0.185 Tw 0 -1.218 TD (\007\036\005\f\021\r\024\r\026\027\027\t\036 \r)Tj /Span<>> BDC ( )Tj EMC (\220\021\017\b \023\030\024\006\036\f\f\026\b. \215\230\206\030\215 \017\ \027\007\031\006\017\030\031)Tj 0 Tw (-)Tj 0.106 Tw T* (\036\021 \f\024\002\t\021\017\016, \f\r\016\026\027\027\t\036 \f)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\020\030\036\f\f\017\030\024\r\026\027\017\036\n \025\217\217\ \027\036 )Tj -0.034 Tw T* (\021\024\035\034\022\024 \f\r\024\017\n \023\030\016\n\t\n \007\036\005\f\ \021\r\017\036\n \027\026)Tj /Span<>> BDC ( )Tj EMC (\022\017\001\036\004\027\t\036 \022\035\036\021\022\017, )Tj 0.049 Tw T* (\027\024 \021\026\022\032\036 \017)Tj /Span<>> BDC ( )Tj EMC (\f\r\024\017\n \r\035\017\016\027\017\036\n \027\026)Tj /Span<>> BDC ( )Tj EMC (\022\035\036\021\022\017 \n\017\022\030\024\024\022\030\031\032\036)Tj 0 Tw (-)Tj 0.281 Tw T* (\027\017\016 \024\023\031\b\024\035\017, \f\023\024\f\024\002\f\021\r\031\ \016 \030\026\r\017\021\017\033 \n\024\035\036\022\031\035\016\030\027\t\ \b )Tj 0.243 Tw 0 -1.218 TD (\017)Tj /Span<>> BDC ( )Tj EMC (\n\024\030\235\024\035\024\020\017\004\036\f\022\017\b \017\n\036\027\036\ \027\017\005 \r)Tj /Span<>> BDC ( )Tj EMC (\022\035\036\021\022\026\b \024\023\031\b\024\035\017. )Tj 0.074 Tw 0 -1.218 TD (\215\230\206\030\215 \017)Tj /Span<>> BDC ( )Tj EMC (\036\020\024 \220\235\235\036\022\021\024\030\t \n\024\020\031\021 \002\t\ \021\034 \r\024\r\035\036\004\036\027\t \r)Tj /Span<>> BDC ( )Tj EMC (\024\027)Tj 0 Tw (-)Tj 0.198 Tw T* (\022\024\020\036\027\036 \017/\017\035\017 \023\030\024\020\030\036\f\f\ \017\030\024\r\026\027\017\036 \026\002\024\035\036\r\026\027\017\016 \025\ \217\217, )Tj 0.023 Tw T* (\026)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\032\036 \n\024\020\031\021 \r\035\017\016\021\034 \027\026)Tj /Span<>> BDC ( )Tj EMC (\031\f\023\036\b \b\017\n\017\024\021\036\030\026\023\036\r\021\017\004\036\ \f\022\024)Tj 0 Tw (-)Tj T* (\020\024 \035\036\004\036\027\017\016.)Tj /T1_2 1 Tf 0.023 Tw 0 -2.436 TD (\223\030\032\255\020\034\036 \032\026\020\017\022\017\026)Tj /T1_1 1 Tf 0.24 Tw 0 -1.218 TD [(\025)-4.1(\024)-4.3(\027)1.7(\006)-6(\036)-6.8(\023)2.2(\006)-6(\017)-5.4(\016 \017)]TJ /Span<>> BDC ( )Tj EMC [(\007)-6(\017)2.7()-9.9(\026\005)1.7(\027 \017)-2.4(\f)3.1(\f)-38.9(\035)-6.8(\036)-19(\007)-4.3(\024)-4.3(\r)-8.9(\026\027)1.7(\017)-5.5(\016)13.7(:)]TJ /T1_3 1 Tf -0.029 Tc 0.269 Tw [( \222)6.3(\205)-33.3(\032)-16.8(\016)-23.9(\026)-24.7(\021)-25.2(\n)-19.4(\027)]TJ /Span<>> BDC 19.794 0 Td ( )Tj EMC [(\201)-31.3(.\217.)-21.2(,)-29( )]TJ -0.007 Tc 0.007 Tw -19.794 -1.218 Td [(\200)-36.9(\205)-11.3(\032\023)-3.7(\031)-2.1(\001\024)-3(\031)-7.9(\032)]TJ /Span<>> BDC 4.8 0 Td ( )Tj EMC [(\216)17.3(.)13.1(\240)12.4(.)]TJ /T1_1 1 Tf 0 Tc 0.883 Tw -4.8 -1.218 Td [(\221)-4.6(\002)-9.9(\024)0.7(\030 \017)]TJ /Span<>> BDC ( )Tj EMC [(\024)-11.8(\002)3(\030)-11.4(\026)-6.3(\002)-9.9(\024)-10.9(\021)-17.7(\022)-19.1(\026 \n)1.3(\026)-11.8(\021)-9.9(\036)-1.7(\030)-7.6(\017)-0.6(\026)-33.1(\035)-2.5(\024)-4.3(\r)10.4(:)]TJ /T1_3 1 Tf -0.029 Tc 0.912 Tw [( \213)-14.9(\020)-18.3(\013)-19.2(\n)-19.4(\027)]TJ /Span<>> BDC 19.021 0 Td ( )Tj EMC [(\240)-9.6(.\215.)-21.2(,)-29.1( )]TJ -0.007 Tc 0.007 Tw -19.021 -1.218 Td [(\200)-36.9(\205)-11.3(\032\023)-3.7(\031)-2.1(\001\024)-3(\031)-7.9(\032)]TJ /Span<>> BDC 4.8 0 Td ( )Tj EMC [(\216)17.3(.)13.1(\240)12.4(.)18.4(.)]TJ /T1_1 1 Tf 0.002 Tc -0.002 Tw -4.8 -1.218 Td [(\203)7.2(\026\023)4.2(\017\f)-10.8(\026)1.7(\027)3.7(\017)-6.7(\036)2.1( \021)-7.9(\036)-3.4(\022\f)-34(\021)-19.5(\026)5.7(:)]TJ /T1_3 1 Tf -0.029 Tc 0.029 Tw 7.694 0 Td [( \222)6.3(\205)-33.3(\032)-16.8(\016)-23.9(\026)-24.7(\021)-25.2(\n)-19.4(\027)]TJ /Span<>> BDC 3.966 0 Td ( )Tj EMC [(\201)-31.3(.\217.)]TJ /T1_1 1 Tf 0 Tc 0 Tw -11.66 -1.218 Td [(\217)5.5(\036)-19(\007)-20.1(\026\022)-32.6(\021)-17.7(\017)1.5(\030)-11.8(\024)-4.4(\r)-8.8(\026\027)1.8(\017)-8.7(\036)6.5(:)]TJ /T1_3 1 Tf -0.029 Tc 0.029 Tw [( \222)6.3(\205)-33.3(\032)-16.8(\016)-23.9(\026)-24.7(\021)-25.2(\n)-19.4(\027)]TJ /Span<>> BDC 11.1 0 Td ( )Tj EMC [(\201)-31.3(.\217.)-21.2(,)-29( \213)-14.9(\020)-18.3(\013)-19.2(\n)-19.4(\027)]TJ /Span<>> BDC 4.826 0 Td ( )Tj EMC [(\240)-9.6(.\215.)]TJ /T1_2 1 Tf 0 Tc 0.023 Tw -15.927 -2.436 Td (AUTHORS CONTRIBUTION)Tj /T1_1 1 Tf 0.06 Tw 0 -1.218 TD [(C)-6.5(o)0.8(nce)-0.7(p)-12.3(t a)2.4(n)-4.6(d d)-5.5(e)-13.3(s)-16.6(i)3.2(g)1.3(n o)-2.1(f t)-16.7(h)-5.3(e s)-20(t)-12.8(ud)-10.9(y)-11.8(:)]TJ /T1_3 1 Tf [( A)3.8(n)4.8(a)-4.9(t)1.5(o)-1.1(l)11(y)]TJ /Span<>> BDC ( )Tj EMC [(N)13(.)]TJ /Span<>> BDC ( )Tj EMC [(K)12.3(u)6.1(r)-14.6(z)12.9(a)-0.8(n)1.9(o)-0.6(v)33.6(, )]TJ 0 Tw T* [(V)0.7(l)3.3(a)-4.5(d)1.4(i)8.5(m)5.8(i)9.4(r)]TJ /Span<>> BDC ( )Tj EMC [(M)5.4(.)]TJ /Span<>> BDC ( )Tj EMC [(Du)6.1(r)-5.9(l)4.8(e)-18(s)9.6(h)3.8(t)2.8(e)-1.7(r)]TJ /T1_1 1 Tf 1.014 Tw T* [(C)-6.5(o)-5.8(l)-19(l)-14.3(e)-9.4(c)-32.5(t)-37.3(i)3.2(o)0.8(n )0.5(a)2.4(n)-4.6(d )0.6(p)-3.8(r)-6(o)-7(ce)-13.3(s)-12.8(s)-16.6(i)7.1(n)-1.9(g )0.6(o)-2.2(f )0.6(t)-16.7(h)-5.3(e )0.5(m)1.8(a)-8.4(t)-15.1(e)-2.1(r)-48(i)5.1(a)-1.5(l)-22.5(:)]TJ /T1_3 1 Tf 0 Tw ( )Tj T* [(M)10.5(i)7.9(k)5.3(h)4.8(a)-2(i)7.4(l)]TJ /Span<>> BDC ( )Tj EMC [(I)2.5(.)]TJ /Span<>> BDC ( )Tj EMC [(B)0.7(y)5.7(k)12.9(ov)33.5(, V)0.7(l)3.3(a)-4.5(d)1.4(i)8.4(m)5.9(i)9.4(r)]TJ /Span<>> BDC ( )Tj EMC [(M)5.4(.)]TJ /Span<>> BDC ( )Tj EMC [(Du)6.1(r)-5.9(l)4.8(e)-17.9(s)9.6(h)3.8(t)2.8(e)-1.7(r)]TJ /T1_1 1 Tf T* [(W)3.1(r)-48(i)-6(t)-37.4(i)7.1(n)-1.9(g o)-2.2(f t)-16.7(h)-5.3(e t)-15.2(e)-23.9(x)-36(t)-20(:)]TJ /T1_3 1 Tf [( A)3.8(n)4.8(a)-4.9(t)1.4(o)-1.1(l)4.3(iy)]TJ /Span<>> BDC ( )Tj EMC [(N)13.1(.)]TJ /Span<>> BDC ( )Tj EMC [(K)12.3(u)6.1(r)-14.6(z)12.9(a)-0.8(n)1.9(o)-0.6(v)]TJ /T1_1 1 Tf 0.006 Tc -0.006 Tw T* [(E)11.6(dit)-31.4(i)13.1(n)4.1(g)15(:)]TJ /T1_3 1 Tf 0 Tc 0 Tw 3.238 0 Td [( A)3.8(n)4.8(a)-4.9(t)1.4(o)-1(l)4.3(iy)]TJ /Span<>> BDC ( )Tj EMC [(N)13(.)]TJ /Span<>> BDC ( )Tj EMC [(K)12.3(u)6.1(r)-14.5(z)12.9(a)-0.8(n)1.9(o)-0.6(v)33.6(, M)10.5(i)7.9(k)5.3(h)4.8(a)-2(i)7.5(l)]TJ /Span<>> BDC ( )Tj EMC [(I)2.5(.)]TJ /Span<>> BDC ( )Tj EMC [(B)0.7(y)5.7(k)12.9(ov)]TJ /T1_2 1 Tf 0.023 Tw 20.007 31.663 Td (\255\026\036\031\036\025\034\224 \017\225 \032\026\020\017\022\032\221 \(\ ORCID\))Tj /T1_1 1 Tf 0.39 Tw T* [(\025\031\030\026\027\024\r )0.5(\202\027\026\021\024\035\017\005 )0.6(\203\017\022\024\035\026\036\r\017\004)]TJ /Span<>> BDC ( )Tj EMC 14.624 0 Td [(\227 )0.5(\007\024\022\021\024\030 )0.5(\n\036\007\017)]TJ 0 Tw (-)Tj 0.126 Tw -14.624 -1.218 Td (\006\017\027\f\022\017\b \027\026\031\022, \023\030\024\235\036\f\f\024\030\ , \023\030\024\235\036\f\f\024\030 \022\026\235\036\007\030\t \235\031\027\ )Tj 0 Tw (-)Tj 0.286 Tw T* (\007\026\n\036\027\021\026\035\034\027\024\005 \017)Tj /Span<>> BDC ( )Tj EMC (\022\035\017\027\017\004\036\f\022\024\005 \002\017\024\b\017\n\017\017 \ \205\206\207\210\211 \200\210 )Tj -0.119 Tw T* [(\253\025\031\002\026\027\f\022\017\005 )0.6(\020\024\f\031\007\026\030\f\021\r\036\027\027\t\005 )0.5(\n\036\007\017\006\017\027\f\022\017\005 )0.6(\031\027\017\r\036\030\f\017)]TJ 0 Tw (-)Tj T* (\021\036\021\273 \204\017\027\007\030\026\r\026 \217\024\f\f\017\017; O\ RCID 0000-0002-0566-256X)Tj 0.319 Tw 0 -1.218 TD (\212\031\030\035\036\001\021\036\030 \200\035\026\007\017\n\017\030 \204\ \024\017\f\036\036\r\017\004)Tj /Span<>> BDC ( )Tj EMC (\227 \007\024\022\021\024\030 \n\036\007\017)Tj 0 Tw (-)Tj 0.583 Tw 0 -1.218 TD (\006\017\027\f\022\017\b \027\026\031\022, \023\030\024\235\036\f\f\024\030\ , \026\n\036\f\021\017\021\036\035\034 \020\035\026\r\027\024\020\024 )Tj 0.237 Tw T* (\r\030\026\004\026 \022\030\026\036\r\024\005 \022\035\017\027\017\004\036\ \f\022\024\005 \002\024\035\034\027\017\006\t \225 2 \023\024)Tj /Span<>> BDC ( )Tj EMC (\b\017)Tj 0 Tw (-)Tj 0.345 Tw T* (\030\031\030\020\017\017, \026\r\036\007\031\033\013\017\005 \022\026\235\ \036\007\030\024\005 \b\017\030\031\030\020\017\017 \2253 \205\215\025 )Tj 0.223 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC [(\215\215\221 )0.5(\205\206\207\210\211 \200\210 )0.5(\253\025\031\002\026\027\f\022\017\005 )0.5(\020\024\f\031\007\026\030\f\021\r\036\027\027\t\005 )0.5(\n\036)]TJ 0 Tw (-)Tj 0.221 Tw T* (\007\017\006\017\027\f\022\017\005 \031\027\017\r\036\030\f\017\021\036\021\ \273 \204\017\027\007\030\026\r\026 \217\024\f\f\017\017; ORCID )Tj 0 Tw 0 -1.218 TD (0000-0002-7420-0553)Tj 0.19 Tw 0 -1.218 TD (\207\t\022\024\r \204\017\b\026\017\035 \222\035\034\017\004)Tj /Span<>> BDC ( )Tj EMC (\227 \007\024\022\021\024\030 \n\036\007\017\006\017\027\f\022\017\b \027\ \026\031\022, )Tj 0.69 Tw 0 -1.218 TD (\023\030\024\235\036\f\f\024\030, \026\r\036\007\031\033\013\017\005 \220\ \027\007\024\f\022\024\023\017\004\036\f\022\017\n \024\021\007\036)Tj 0 Tw (-)Tj 0.198 Tw T* (\035\036\027\017\036\n \225 2, \206\207\211\003 \203\222\222)Tj /Span<>> BDC ( )Tj EMC (\227 \025\025\207 \2251 \017\n. \023\030\024\235. \221.\200. )Tj 0.079 Tw T* (\210\004\026\023\024\r\f\022\024\020\024, \023\030\024\235\036\f\f\024\030\ \022\026\235\036\007\030\t \b\017\030\031\030\020\017\017 \2251 \205\215\ \025 )Tj 0.303 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC [(\215\215\221 \205\206\207\210\211 )0.5(\200\210 \025\031\002\026\027\f\022\017\005 )0.5(\020\024\f\031\007\026\030\f\021\r\036\027\027\t\005 )0.5(\n\036)]TJ 0 Tw (-)Tj 0.341 Tw T* (\007\017\006\017\027\f\022\017\005 \031\027\017\r\036\030\f\017\021\036\021\ \204\017\027\007\030\026\r\026 \217\024\f\f\017\017; ORCID )Tj 0 Tw T* (0000-0002-2000-3407)Tj /T1_2 1 Tf 0.023 Tw 0 -2.436 TD (INFORMATION ABOUT THE AUTHORS \(ORCID\))Tj /T1_1 1 Tf 0 Tw 0 -1.218 TD [(Ana)15(t)17(ol)-30.9(iy N. K)25(ur)-24(zanov)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0002-0566-256X)Tj T* [(Vl)-16(adimir M. Dur)-29.9(leshter)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0002-7420-0553)Tj T* (Mikhail I. Bykov)Tj /Span<>> BDC ( )Tj EMC (\227 0000-0002-2000-3407)Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 42.5896 371.6679 Tm [(\r\031\024\034\033)48(\026)45(\024)-10(\223\033)48(\026/REFERENCES)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0 Tc 0.115 Tw 8 0 0 8 42.5197 358.8332 Tm (1.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (Sung)Tj /Span<>> BDC ( )Tj EMC [(H, F)10(er)-30(l)-16(a)15(y)]TJ /Span<>> BDC ( )Tj EMC [(J, S)-16(iegel)]TJ /Span<>> BDC ( )Tj EMC [(RL, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Gl)30(obal Cancer S)15(t)15(a)15(t)-31.9(ist)-32(ics 2020: )]TJ 0.17 Tw -1.296 -1.25 Td [(GL)35(OBOC)20(A)51(N Est)-32(ima)15.1(tes of Inc)-24(idence and M)-24(or)-22(t)15(al)-31(i)-23.9(t)-10(y W)20(or)-30(ld)-17(wide for 36 )]TJ 0.229 Tw 0 -1.25 TD [(Cancer)-10(s in 185 Countr)-36.9(ies. )]TJ /T1_3 1 Tf [(C)-18(A Cancer J Clin)]TJ /T1_1 1 Tf (. 2021;71\(3\):209\226249. )Tj 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td [(10.3322/caa)-17(c.21660)]TJ 0 0 0 1 k /GS1 gs 0.188 Tw -1.847 -1.25 Td (2.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(N)-14(ovoa D\355a)-24(z)]TJ /Span<>> BDC ( )Tj EMC [(MB, Mar)-22(t\355n)]TJ /Span<>> BDC ( )Tj EMC [(MJ, Gent)-32(il)-30.9(i)]TJ /Span<>> BDC ( )Tj EMC [(C. T)60(umor micr)-32(oenv)-15.9(ir)-32(onment )]TJ 0.343 Tw -1.296 -1.25 Td [(invol)30(vement in col)30(or)-24(ec)-15.9(t)15(al cancer p)25(r)-32(o)-15.9(gr)-24(ession v)-16(ia W)44(nt/\256-ca)15(tenin )]TJ 0.212 Tw T* [(p)32(a)15(t)-13(hw)-12(a)15.1(y: P)35(r)-31.9(ov)-16(iding under)-10(st)15(anding of t)-13(he com)10(ple)-18(x mechanis)26(ms of )]TJ 0 Tw T* [(chemor)-24(esist)15.1(ance)]TJ /T1_3 1 Tf 0.211 Tw [(. W)29(orld J Gastroenterol. )]TJ /T1_1 1 Tf 0 Tw (2022a;28\(26\):3027\2263046. )Tj T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.3748/wjg.v28.i26.3027)Tj 0 0 0 1 k /GS1 gs 0.006 Tc 0.349 Tw -1.847 -1.25 Td (3.)Tj /Span<>> BDC ( )Tj EMC 1.313 0 Td [(Sa)-16.7(gaer)-21.7(t)]TJ /Span<>> BDC ( )Tj EMC [(X, V)25.3(anst)15.3(apel)]TJ /Span<>> BDC ( )Tj EMC [(A, V)30.3(er)-23.7(beek)]TJ /Span<>> BDC ( )Tj EMC [(S. T)60.3(umor He)-11.7(ter)-31.7(o)-15.7(genei)-23.7(t)-9.7(y in)6( )]TJ 0 Tc 0.2 Tw -1.313 -1.25 Td [(Col)30(or)-24(ec)-15.9(t)15(al Cancer: Wha)15(t Do W)22.1(e Kno)-14(w S)-16(o F)20(ar? )]TJ /T1_3 1 Tf 0 Tw [(P)18(athobiology)]TJ /T1_1 1 Tf 0.2 Tw (. 2018; )Tj 0.023 Tw T* [(85\(1-2\):72\22684. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1159/000486721)Tj 0 0 0 1 k /GS1 gs 0.012 Tc 0.434 Tw T* (4.)Tj /Span<>> BDC ( )Tj EMC 1.331 0 Td [(K)25.2(ol)-30.7(iar)-32.7(ak)-15.7(i)]TJ /Span<>> BDC ( )Tj EMC [(V, P)40.3(all)-15.7(ang)16.3(yo)]TJ /Span<>> BDC ( )Tj EMC [(CK, G)20.3(r)-23.8(e)-11.7(ten)]TJ /Span<>> BDC ( )Tj EMC [(FR, e)-11.7(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Mesenchymal)12( )]TJ 0.01 Tc 0.381 Tw -1.331 -1.25 Td [(Cells in Col)29.8(on Cancer. )]TJ /T1_3 1 Tf -0.01 Tw (Gastroenterology)Tj /T1_1 1 Tf 0.381 Tw [(. 2017;152\(5\):964\226979.)10( )]TJ 0 Tc 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td [(10.1053/j.gastr)-31.9(o.2016.11.049)]TJ 0 0 0 1 k /GS1 gs 0.055 Tw -1.847 -1.25 Td (5.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Sandber)-32(g)]TJ /Span<>> BDC ( )Tj EMC [(TP, )0.5(S)15(tuar)-22(t )0.5(MPME, Oost)-32(ing)]TJ /Span<>> BDC ( )Tj EMC 14.464 0 Td [(J, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC 2.042 0 Td [(al. Incr)-23.9(eased e)-18(xp)25.1(r)-24(ession )]TJ 0.204 Tw -17.802 -1.25 Td [(of cancer-asso)-15.9(c)-24(ia)15(ted f)-28(ibr)-32(obl)-15.9(ast mar)-24(k)10(er)-10(s a)15(t t)-12.9(he inv)-15(asi)-16(ve fr)-31.9(ont and )]TJ 0.182 Tw T* [(i)-24(ts asso)-16(c)-24(ia)15(t)-32(ion wi)-24(t)-13(h tumor-str)-32(oma r)-33(a)15(t)-32(io in col)30(or)-24(ec)-16(t)15(al cancer. )]TJ /T1_3 1 Tf 0 Tw (BMC )Tj T* (Cancer)Tj /T1_1 1 Tf 0.023 Tw [(. 2019;19\(1\):284. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1186/s12885-019-5462-2)Tj 0 0 0 1 k /GS1 gs 0.01 Tc 0.387 Tw T* (6.)Tj /Span<>> BDC ( )Tj EMC 1.327 0 Td [(Y)49.6(aha)14.7(y)21.5(a)]TJ /Span<>> BDC ( )Tj EMC [(MAF, L)-32.3(il)-16.4(a)]TJ /Span<>> BDC ( )Tj EMC [(MAM, Is)25.6(mail)]TJ /Span<>> BDC ( )Tj EMC [(S, e)-12.4(t)]TJ /Span<>> BDC ( )Tj EMC [(al. T)59.6(umour-Asso)-16.4(c)-24.4(ia)14.6(ted)10( )]TJ 0 Tc 0.126 Tw -1.327 -1.25 Td [(Ma)-17(cr)-32(opha)-17(ges \(T)35(AMs\) in Col)30(on Cancer and Ho)-14(w t)17(o R)13(eeduca)15.1(te T)47(hem. )]TJ /T1_3 1 Tf 0.023 Tw T* [(J Immunol R)21(es)]TJ /T1_1 1 Tf [(. 2019;2019:2368249. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1155/2019/2368249)Tj 0 0 0 1 k /GS1 gs 0.107 Tw T* (7.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(U)13(nter)-30(leut)-12.9(hner)]TJ /Span<>> BDC ( )Tj EMC (D, Neuhold)Tj /Span<>> BDC ( )Tj EMC [(P, S)-24(chw)-11.9(ar)-24(z)]TJ /Span<>> BDC ( )Tj EMC [(K, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Cancer-asso)-16(c)-24(ia)15(ted )]TJ 0.002 Tc 0.35 Tw -1.296 -1.25 Td [(f)-28.3(ibr)-32.4(obl)-16.3(ast-der)-37.3(i)-16.3(ved WNT2 incr)-24.3(eases tumor angio)-16.3(genesis in col)29.7(on)2( )]TJ 0 Tc 0 Tw T* (cancer. )Tj /T1_3 1 Tf 3.442 0 Td [(Angiog)12(enesis)]TJ /T1_1 1 Tf 0.275 Tw [(. 2020;23\(2\):159\226177. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1007/s10456-)Tj -3.442 -1.25 Td (019-09688-8)Tj 0 0 0 1 k /GS1 gs 0.145 Tw T* (8.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (Qian)Tj /Span<>> BDC ( )Tj EMC [(Y, W)16(u)]TJ /Span<>> BDC ( )Tj EMC [(X, Y)40(okoy)22(ama)]TJ /Span<>> BDC ( )Tj EMC [(Y, e)-11.9(t)]TJ /Span<>> BDC ( )Tj EMC [(al. E-cadher)-37(in-F)10(c chimer)-33(a p)25(r)-32(o)17(tein )]TJ 0.023 Tw -1.296 -1.25 Td [(ma)15(tr)-37(ix )0.5(enhances cancer stem-l)-30.9(ik)10(e p)25(r)-32(oper)-22(t)-31.9(ies and induces mesenchy)]TJ 0 Tw 27.286 0 Td (-)Tj 0.116 Tw 1.769 33.75 Td [(mal fea)15(tur)-24(es in col)30(on cancer cells. )]TJ /T1_3 1 Tf (Cancer Sci.)Tj /T1_1 1 Tf ( 2019;110\(11\):3520\226)Tj 0.023 Tw T* [(3532. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1111/cas.14193)Tj 0 0 0 1 k /GS1 gs 0.167 Tw T* (9.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (Ning)Tj /Span<>> BDC ( )Tj EMC [(X, W)12(ang)]TJ /Span<>> BDC ( )Tj EMC (C, Zhang)Tj /Span<>> BDC ( )Tj EMC [(M, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. E)15(c)-16(t)17(opic E)35(xp)25(r)-24(ession of miR-147 )]TJ 0.274 Tw -1.296 -1.25 Td [(Inhibi)-23.9(ts S)15(tem Cell Mar)-23.9(k)9.9(er and Epi)-24(t)-13(hel)-30.9(ial-Mesenchymal T)50(r)-32.9(ansi)-24(t)-32(ion )]TJ 0.161 Tw T* [(\(EMT\)-R)13(el)-15.9(a)15(ted )0.5(P)35(r)-32(o)17(tein )0.5(E)35(xp)25(r)-24(ession )0.5(in )0.5(Col)30(on )0.5(Cancer )0.5(Cells. )]TJ /T1_3 1 Tf 23.472 0 Td [(Oncol )0.5(R)21(es.)]TJ /T1_1 1 Tf 0 Tw ( )Tj 0.023 Tw -23.472 -1.25 Td [(2019;27\(4\):399\226406. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.3727/096504018X15179675206495)Tj 0 0 0 1 k /GS1 gs -0.096 Tw T* (10.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Ha)15(t)15(ano)]TJ /Span<>> BDC ( )Tj EMC [(Y, F)10(ukud)42(a)]TJ /Span<>> BDC ( )Tj EMC [(S, Hisama)15.1(tsu)]TJ /Span<>> BDC ( )Tj EMC [(K, e)-11.9(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Mul)56.1(t)-32(if)16(a)-17(ce)-12(ted Inter)-23.9(p)25(r)-24(e)-12(t)15(a)15(t)-32(ion )]TJ 0.011 Tc 0.395 Tw -1.796 -1.25 Td [(of Col)30.4(on Cancer S)15.4(tem Cells. )]TJ /T1_3 1 Tf (Int J Mol Sci.)Tj /T1_1 1 Tf [( 2017;18\(7\):1446.)11( )]TJ 0 Tc 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.3390/ijms18071446)Tj 0 0 0 1 k /GS1 gs 0.002 Tc 0.35 Tw -1.847 -1.25 Td (11.)Tj /Span<>> BDC ( )Tj EMC 1.805 0 Td [(Cher)-22.4(uku)]TJ /Span<>> BDC ( )Tj EMC [(HR, M)-24.3(ohamed)41.6(al)-31.4(i)]TJ /Span<>> BDC ( )Tj EMC [(A, Cant)16.6(or)]TJ /Span<>> BDC ( )Tj EMC [(DI, e)-12.3(t)]TJ /Span<>> BDC ( )Tj EMC [(al. T)49.6(r)-33.3(ansfor)-16.3(ming)2( )]TJ 0 Tc 0.082 Tw -1.805 -1.25 Td [(gr)-32(o)-14(w)-23.9(t)-13(h f)16(a)-17(c)-16(t)17(or-\256, MAPK and W)44(nt signal)-31(ing inter)-32.9(a)-17(c)-16(t)-32(ions in col)30.1(or)-24(ec)-16(t)15(al )]TJ 0 Tw T* (cancer. )Tj /T1_3 1 Tf 0.317 Tw 3.484 0 Td [(EuP)45(A Open Pro)13(teomics.)]TJ /T1_1 1 Tf [( 2015;8:104\226115. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1016/j.)Tj -3.484 -1.25 Td [(eup)25(r)-32(o)17(t.2015.06.004)]TJ 0 0 0 1 k /GS1 gs 0.095 Tw T* (12.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(P)40(andur)-33(angan)]TJ /Span<>> BDC ( )Tj EMC [(AK. P)10(o)17(tent)-32(ial )0.5(t)15(ar)-32(ge)-12(ts for p)25(r)-23.9(event)-32(ion of col)30(or)-23.9(ec)-16(t)15(al )]TJ 0.122 Tw -1.796 -1.25 Td [(cancer: )0.5(a )0.5(fo)-16(cus )0.5(on )0.5(PI3K/Ak)-23.9(t/mT)20(OR )0.5(and )0.5(W)44(nt )0.5(p)32(a)15(t)-13(hw)-12(a)15(y)-13(s. )0.5(Asian )0.5(P)40.1(a)-17(c J )]TJ -0.095 Tw T* [(Cancer P)35(r)-24(ev. 2013;14\(4\):2201\2265. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.7314/apjcp.2013.14.4.2201)Tj 0 0 0 1 k /GS1 gs 0.195 Tw T* (13.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Khaleghpour)Tj /Span<>> BDC ( )Tj EMC [(K, L)-32(i)]TJ /Span<>> BDC ( )Tj EMC [(Y, Banv)-16(ille)]TJ /Span<>> BDC ( )Tj EMC [(D, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Invol)30.1(vement of t)-13(he PI )]TJ 0.004 Tw -1.796 -1.25 Td [(3-k)-16(inase signal)-31(ing p)32(a)15(t)-13(hw)-12(a)15(y in p)25(r)-32(o)-16(gr)-23.9(ession of col)30(on adeno)-16(car)-32(c)-23.9(inoma. )]TJ /T1_3 1 Tf 0 Tw T* [(Carcinog)12.1(enesis)]TJ /T1_1 1 Tf 0.023 Tw [(. 2004;25\(2\):241\2268. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw [(10.1093/car)-32(c)-23.9(in/bgg195)]TJ 0 0 0 1 k /GS1 gs 0.019 Tw T* (14.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Chen)Tj /Span<>> BDC ( )Tj EMC [(J, Elf)-28(ik)-32(y)]TJ /Span<>> BDC ( )Tj EMC (A, Han)Tj /Span<>> BDC ( )Tj EMC [(M, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. T)47(he r)-32(ole of Sr)-32(c in col)30(on cancer and )]TJ 0.175 Tw -1.796 -1.25 Td [(i)-24(ts t)-12.9(her)-33(apeut)-32(ic im)10(pl)-30.9(ica)15(t)-32(ions. )]TJ /T1_3 1 Tf (Clin Colorectal Cancer.)Tj /T1_1 1 Tf ( 2014;13\(1\):5\226)Tj 0.023 Tw T* [(13. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw [(10.1016/j.cl)16(cc.2013.10.003)]TJ 0 0 0 1 k /GS1 gs 0.328 Tw T* (15.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Ir)-24(esj\366)]TJ /Span<>> BDC ( )Tj EMC (BM, Kir)Tj /Span<>> BDC ( )Tj EMC [(S, L)35(undholm)]TJ /Span<>> BDC ( )Tj EMC [(K. P)40(ar)-32.9(a)15(t)-13(hyr)-32(oid hor)-16(mone r)-23.9(el)-16(a)15(ted )]TJ 0.22 Tw -1.796 -1.25 Td [(p)25(r)-32(o)17(tein \(PTHrP\) in p)32(a)15(t)-32(ients wi)-24(t)-13(h p)32(ancr)-23.9(ea)15(t)-32(ic car)-32(c)-24(inoma and over)-22(t )]TJ 0.121 Tw T* [(signs of disease p)25(r)-32(o)-16(gr)-23.9(ession and host t)-32(issue w)-11.9(ast)-32(ing. )]TJ /T1_3 1 Tf [(T)56(ransl Oncol.)]TJ /T1_1 1 Tf 0 Tw ( )Tj 0.023 Tw T* [(2023;36:101752. d)-15.9(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw [(10.1016/j.tr)-33(anon.2023.101752)]TJ 0 0 0 1 k /GS1 gs 0.152 Tw T* (16.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Iino)Tj /Span<>> BDC ( )Tj EMC [(C, S)-16(himoy)22(ama)]TJ /Span<>> BDC ( )Tj EMC [(T, Ak)10(emo)17(t)17(o)]TJ /Span<>> BDC ( )Tj EMC [(Y, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Humor)-32.9(alhyper)-32(cal)16(cemia )]TJ 0.287 Tw -1.796 -1.25 Td [(due t)17.1(o gastr)-37(ic car)-32(c)-24(inoma secr)-24(e)-12(t)-32(ing p)32(ar)-33(a)15(t)-13(hyr)-31.9(oid hor)-16(mone-r)-23.9(el)-16(a)15(ted )]TJ 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 0 Tw 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\214)10(\211\036\033 \035\030\032\t\033)30(\b)42(\032)-21(\240\033\233)]TJ 57.136 0 Td (REVIEW)Tj /T1_5 1 Tf 25 0 0 25 505.5145 56.0378 Tm (169)Tj ET endstream endobj 422 0 obj <>/Border[0 0 0]/H/N/Rect[57.2978 336.129 124.113 326.833]/Subtype/Link/Type/Annot>> endobj 423 0 obj <>/Border[0 0 0]/H/N/Rect[57.2978 286.129 143.369 276.833]/Subtype/Link/Type/Annot>> endobj 424 0 obj <>/Border[0 0 0]/H/N/Rect[109.268 256.129 175.18 246.833]/Subtype/Link/Type/Annot>> endobj 425 0 obj <>/Border[0 0 0]/H/N/Rect[57.2978 226.129 155.321 216.833]/Subtype/Link/Type/Annot>> endobj 426 0 obj <>/Border[0 0 0]/H/N/Rect[137.43 186.129 230.901 176.673]/Subtype/Link/Type/Annot>> endobj 427 0 obj <>/Border[0 0 0]/H/N/Rect[177.202 156.129 254.658 146.673]/Subtype/Link/Type/Annot>> endobj 428 0 obj <>/Border[0 0 0]/H/N/Rect[207.782 126.129 263.622 116.673]/Subtype/Link/Type/Annot>> endobj 429 0 obj <>/Border[0 0 0]/H/N/Rect[42.5197 116.129 84.1515 106.833]/Subtype/Link/Type/Annot>> endobj 430 0 obj <>/Border[0 0 0]/H/N/Rect[310.157 356.129 372.749 346.833]/Subtype/Link/Type/Annot>> endobj 431 0 obj <>/Border[0 0 0]/H/N/Rect[361.381 316.129 487.14 306.833]/Subtype/Link/Type/Annot>> endobj 432 0 obj <>/Border[0 0 0]/H/N/Rect[289.739 286.129 364.994 276.833]/Subtype/Link/Type/Annot>> endobj 433 0 obj <>/Border[0 0 0]/H/N/Rect[461.551 256.129 496.063 246.673]/Subtype/Link/Type/Annot>> endobj 434 0 obj <>/Border[0 0 0]/H/N/Rect[274.961 246.129 339.216 236.833]/Subtype/Link/Type/Annot>> endobj 435 0 obj <>/Border[0 0 0]/H/N/Rect[395.216 216.129 496.063 206.833]/Subtype/Link/Type/Annot>> endobj 436 0 obj <>/Border[0 0 0]/H/N/Rect[403.502 186.129 481.006 176.673]/Subtype/Link/Type/Annot>> endobj 437 0 obj <>/Border[0 0 0]/H/N/Rect[302.157 156.129 392.204 146.833]/Subtype/Link/Type/Annot>> endobj 438 0 obj <>/Border[0 0 0]/H/N/Rect[347.013 116.129 447.868 106.833]/Subtype/Link/Type/Annot>> endobj 455 0 obj <> endobj 454 0 obj <> endobj 453 0 obj <> endobj 452 0 obj <> endobj 451 0 obj <> endobj 450 0 obj <> endobj 449 0 obj <> endobj 448 0 obj <> endobj 447 0 obj <> endobj 446 0 obj <> endobj 445 0 obj <> endobj 444 0 obj <> endobj 443 0 obj <> endobj 442 0 obj <> endobj 441 0 obj <> endobj 440 0 obj <> endobj 439 0 obj <> endobj 329 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.1 Tw 10 0 0 10 70.8661 724.8299 Tm (\022\035\036\021\024\022 \025\217\217. \215\024\022\026\026\027\024, \004\ \021\024 \215\230\206\030\215 )Tj /T1_1 1 Tf [(in viv)13(o)]TJ /T1_0 1 Tf ( \n\024\007\031\035\017\030\031\036\021 )Tj 0.214 Tw 0 -1.218 TD (\220\022\f\023\030\036\f\f\017\033 \n\026\030\022\036\030\024\r, \f\r\016\ \026\027\027\t\b \f)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\020\030\036\f\f\017\030\024\r\026)Tj 0 Tw (-)Tj 0.144 Tw T* [(\027\017\036\n \024\023\031\b\024\035\017 \(\r\022\035\033\004\026\016 M\ e)-12(t\), \026)]TJ /Span<>> BDC ( )Tj EMC (\021\026\022\032\036 \f\024\002\f\021\r\036\027\027\024\020\024 )Tj 0 Tw T* (\030\036\006\036\023\021\024\030\026.)Tj /T1_2 1 Tf 0.318 Tw 0 -2.436 TD [(\026\f\t\235\b\t\r )0.5(\200\020\027\006\200 )0.6(\b\004)]TJ /Span<>> BDC ( )Tj EMC 9.139 0 Td [(\214\002\240\210\f\235\204\t\211 )0.5(\212\006\002\n\006\004\214\214\013 )0.6(\234\212\t)]TJ 0 Tw (-)Tj 0.003 Tc 0.349 Tw -9.139 -1.218 Td (\003\r\f\t\004\f\001\b\002-\214\r\213\r\b\216\t\214\004\f\001\b\002\n\002\ \212\r\006\r\216\002\240\004 \t)Tj /Span<>> BDC ( )Tj EMC [(\240\006\210\n\t\216)3( )]TJ 0 Tc 0.023 Tw 0 -1.218 TD (\217\002\206\013\003\t\005, \217\235\213\004\b\b\013\216 \217)Tj /Span<>> BDC ( )Tj EMC (\t\b\004\213\t\r\005 \002\212\210\216\002\f\t)Tj /T1_0 1 Tf 0.299 Tw T* [(\205\026\022\021\t )0.5(\024)]TJ /Span<>> BDC ( )Tj EMC [(\021\024\n, \004\021\024 \215\230\206\030\215 )0.5(\f\023\024\f\024\002\f\021\r\031\036\021 )0.5(\b\017\n\017\024\030\036\017)]TJ 0 Tw (-)Tj 0.307 Tw T* (\f\021\036\027\021\027\024\f\021\017 \022\035\036\021\024\022 \025\217\217\ \017)Tj /Span<>> BDC ( )Tj EMC (\026\027\020\017\024\020\036\027\036\031, \f\r\016\026\027\027\024\n\031\ )Tj 0.107 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\220\021\017\n\017 \024\023\031\b\024\035\036\r\t\n\017 \022\035\036\021\ \022\026\n\017, \016\r\017\035\017\f\034 \035\024\020\017\004\036\f\022\024\ \005 )Tj 0.011 Tw T* (\023\030\036\007\023\024\f\t\035\022\024\005 \007\035\016 \017\f\f\035\036\ \007\024\r\026\027\017\005 \031\004\026\f\021\017\016 \220\021\024\020\024\ \n\031\035\034)Tj 0 Tw (-)Tj 0.18 Tw 0 -1.218 TD (\021\017\023\024\021\036\027\021\027\024\020\024 \006\017\021\024\022\017\ \027\026 \021\026\022\032\036 \017)Tj /Span<>> BDC ( )Tj EMC (\r \007\030\031\020\017\b \f\024\002\t\021\017\016\b, )Tj 0.254 Tw 0 -1.218 TD (\f\r\016\026\027\027\t\b \f)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\020\030\036\f\f\017\030\024\r\026\027\017\036\n \024\023\031\ \b\024\035\017. \215\030\024\006\036\f\f )Tj 0.241 Tw 0 -1.218 TD (\017\027\r\026\017\017 \021\030\036\002\031\036\021 \023\030\017\024\002\ \030\036\021\036\027\017\016 \b\026\030\026\022\021\036\030\017\f\021\017\ \022 \024\023\031)Tj 0 Tw (-)Tj 0.227 Tw T* (\b\024\035\036\r\t\n\017 \022\035\036\021\022\026\n\017 \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\017\f\031\021\f\021\r\017\016 \030\026\035\017\004\027\t\b \235\ \026\022)Tj 0 Tw (-)Tj 0.15 Tw T* (\021\024\030\024\r \024\022\030\031\032\026\033\013\036\005 \f\030\036\007\ \t, \022\024\021\024\030\t\036 \031\004\026\f\021\r\031\033\021 \r)Tj /Span<>> BDC ( )Tj EMC (\030\036)Tj 0 Tw (-)Tj 0.237 Tw T* (\n\024\007\036\035\017\030\024\r\026\027\017\017 \r\027\036\022\035\036\021\ \024\004\027\024\020\024 \n\026\021\030\017\022\f\026, \021\026\022\017\b\ \022\026\022 )Tj 0.137 Tw T* (\n\026\021\030\017\022\f\027\t\036 \n\036\021\026\035\035\024\023\030\024\ \021\036\017\027\026\t \(\204\204\215\). \217\026\027\036\036 \002\t\035\ \024 )Tj 0.09 Tw T* [(\031\f\021\026\027\024\r\035\036\027\024, \004\021\024 \204\204\215-7 \017\ \002\t\021\024\004\027\024 )0.5(\220\022\f\023\030\036\f\f\017\030\031\036\021\f\016 )]TJ 0.008 Tw T* (\031)Tj /Span<>> BDC ( )Tj EMC (80% \023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC [(\025\217\217 [66]. N)-14(ovoa D\355a)-24(z M.B. \017)]TJ /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. )Tj 0.07 Tw T* ([44] \r)Tj /Span<>> BDC ( )Tj EMC (\220\022\f\023\036\030\017\n\036\027\021\026\b )Tj /T1_1 1 Tf (in vitro)Tj /T1_0 1 Tf ( \021\026\022\032\036 \024\002\027\026\030\031\032\017\035\017, \004\021\ \024 )Tj 0.235 Tw T* (\024\002\030\026\002\024\021\022\026 \215\230\206\030\215 \r\t\t\r\026\036\ \021 \031\r\036\035\017\004\036\027\017\036 \021\030\026\027\f\022\030\017\ \023)Tj 0 Tw (-)Tj 0.141 Tw T* [(\006\017\017 )0.5(\204\204\217-7 \r)]TJ /Span<>> BDC ( )Tj EMC 5.836 0 Td [(\022\035\036\021\022\026\b )0.5(\025\217\217. )0.5(\200)]TJ /Span<>> BDC ( )Tj EMC [(\220\021\024\n )0.5(\032\036 )0.5(\017\f\f\035\036\007\024\r\026\027\017\017 )]TJ 0.216 Tw -5.836 -1.218 Td (\002\t\035\024 \017\031\004\036\027\024 \r\035\017\016\027\017\036 \215\ \230\206\030\215 \027\026)Tj /Span<>> BDC ( )Tj EMC (\n\024\030\235\024\035\024\020\017\004\036\f\022\017\036 )Tj 0.138 Tw T* [(\017\n\036\027\036\027\017\016 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC [(\022\035\036\021\022\026\b )0.5(\025\217\217, \f\r\016\026\027\027\t\036 \f)]TJ /Span<>> BDC ( )Tj EMC (\023\030\024\020\030\036\f\f\017\036\005 )Tj -0.031 Tw T* [(\024\023\031\b\024\035\017, )0.5(\r\022\035\033\004\026\016 \030\024\035\034 )0.5(\215\230\206\030\215 \r)]TJ /Span<>> BDC ( )Tj EMC (\023\030\024\006\036\f\f\036 \220\023\017\021\036\035\017\026\035\034)Tj 0 Tw (-)Tj -0.005 Tw T* [(\027\024-\n\036\036\027\b\017\n\026\035\034\027\024\020\024 )0.5(\023\036\030\036\b\024\007\026 \(\224\204\215\), \022\024\021\024\030\t\005\ \f\004\017\021\026)]TJ 0 Tw (-)Tj -0.007 Tw T* (\036\021\f\016 \r\026\032\027\t\n \220\021\026\023\024\n \r)Tj /Span<>> BDC ( )Tj EMC (\030\026\r\017\021\017\017 \030\026\035\017\004\027\t\b \024\023\031\b\ \024\035\036\005. )Tj -0.045 Tw T* (\200\024)Tj /Span<>> BDC ( )Tj EMC (\r\030\036\n\016 \224\204\215 \220\023\017\021\036\035\017\026\035\034\027\ \t\036 \022\035\036\021\022\017 \031\n\036\027\034\001\026\033\021 \n\036\ \032)Tj 0 Tw (-)Tj 0.13 Tw T* (\022\035\036\021\024\004\027\031\033 \026\007\020\036\017\033 \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\017\024\002\030\036\021\026\033\021 \n\036\036\027\b\017\n\026\ \035\034\027\t\036 )Tj 0.195 Tw T* (\f\r\024\005\f\021\r\026, \023\024\r\t\001\026\033\013\017\036 \017\b \f\ \023\024\f\024\002\027\024\f\021\034 \022)Tj /Span<>> BDC ( )Tj EMC (\n\017\020\030\026\006\017\017 )Tj 0.16 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\017\027\r\026\017\017, \023\030\017\027\026\027\027\t\036 \b\026\030\026\ \022\021\036\030\017\f\021\017\022\017 \024\023\031\b\024\035\036\r\t\b \ )Tj 0 Tw T* (\022\035\036\021\024\022 [67].)Tj 0.116 Tw T* [(Car)-24(r)-36.9(ier)-24(e P. \017)]TJ /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. [68] \002\t\035\017 \023\024\035\031\004\036\027\t \030\ \036\031\035\034\021\026\021\t, )Tj 0.078 Tw T* (\023\024\r\024\035\017\r\001\017\036 \022\024\027\f\021\026\021\017\030\ \024\r\026\021\034, \004\021\024 \215\230\206\030\215 \n\024\007\031\035\ \017\030\031\036\021 )Tj 0.12 Tw T* (\220\022\f\023\030\036\f\f\017\033 \235\026\022\021\024\030\024\r \017)Tj /Span<>> BDC ( )Tj EMC (\f\023\024\f\024\002\f\021\r\031\036\021 \n\024\030\235\024\035\024\020\017\ \004\036)Tj 0 Tw (-)Tj 0.047 Tw T* (\f\022\017\n \017\n\036\027\036\027\017\016\n, \f\r\016\026\027\027\t\n\ \f)Tj /Span<>> BDC ( )Tj EMC (\224\204\215, \r)Tj /Span<>> BDC ( )Tj EMC (\022\035\036\021\024\004\027\024\005 \035\017)Tj 0 Tw (-)Tj 0.14 Tw T* (\027\017\017 HCT116, \023\024\035\031\004\036\027\027\024\005 \017)Tj /Span<>> BDC ( )Tj EMC (\025\217\217. \215\230\206\030\215 \031\r\036\035\017\004\017\r\026\035 \ )Tj 0.02 Tw T* [(\220\022\f\023\030\036\f\f\017\033 \002\036\035\022\026 SP)25(ARC \(secr)-24(e)-12(ted p)25(r)-32(o)17(tein a)-17(c)-24(idicr)-36.9(ich)]TJ 0 Tw (-)Tj 0.023 Tw T* [(incy)-13(stein\), \022\024\021\024\030\t\005 \030\036\020\031\035\017\030\031\036\ \021 \023\030\024\035\017\235\036\030\026\006\017\033 \017)]TJ /Span<>> BDC ( )Tj EMC (\r\026)Tj 0 Tw (-)Tj -0.055 Tw T* [(\017\n\024\007\036\005\f\021\r\017\016 \022\035\036\021\024\022 \n\026\021\ \030\017\022\f\026. SP)25(ARC \031\004\026\f\021\r\031\036\021 \r)]TJ /Span<>> BDC ( )Tj EMC (\224\204\215, )Tj 0.029 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\022\035\036\021\022\026\b HCT116, \027\024 \027\036 \r)Tj /Span<>> BDC ( )Tj EMC [(\022\035\036\021\022\026\b Ca)-17(co-2. \215\230\206\030\215 \021\026\022)]TJ 0 Tw (-)Tj -0.005 Tw T* [(\032\036 \031\r\036\035\017\004\017\r\026\035 \220\022\f\023\030\036\f\f\ \017\033 SP)25(ARC \017)]TJ /Span<>> BDC ( )Tj EMC (\036\020\024 \023\024\f\035\036\007\031\033\013\036\036 )Tj 0.188 Tw T* (\r\t\f\r\024\002\024\032\007\036\027\017\036 \017)Tj /Span<>> BDC ( )Tj EMC (\220\027\007\024\021\036\035\017\026\035\034\027\t\b \022\035\036\021\024\ \022 HMEC-1. )Tj 0.504 Tw T* (\025\024\027\007\017\006\017\024\027\017\030\024\r\026\027\027\026\016 \f\ \030\036\007\026 \024\002\030\026\002\024\021\026\027\027\t\b \215\230\206\ \030\215 )Tj -0.021 Tw T* (\022\035\036\021\024\022 HMEC-1 \017\027\007\031\006\017\030\024\r\026\035\ \026 \030\026\027\027\017\036 \017\n\036\027\036\027\017\016, \f\r\016)Tj 0 Tw (-)Tj 0.001 Tw T* (\026\027\027\t\036 \f)Tj /Span<>> BDC ( )Tj EMC (\224M\215 \r)Tj /Span<>> BDC ( )Tj EMC (\022\035\036\021\022\026\b HCT116. \207\024\035\036\036 \021\024\020\024\ , \024\002\030\026\002\024\021)Tj 0 Tw (-)Tj -0.003 Tw T* [(\022\026 SP)25(ARC \022\035\036\021\024\022 HCT116 \031\f\017\035\017\r\026\035\026 \n\024\ \007\031\035\016\006\017\033 \215\230\206\030\215 )]TJ 0.256 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\220\022\f\023\030\036\f\f\017\017 E-\022\026\007\020\036\030\017\027\026\ \017)Tj /Span<>> BDC ( )Tj EMC (\n\017\020\030\026\006\017\017 \022\035\036\021\024\022. \224\021\017 )Tj -0.011 Tw T* (\030\036\031\035\034\021\026\021\t \f\r\017\007\036\021\036\035\034\f\021\ \r\031\033\021 \024)Tj /Span<>> BDC ( )Tj EMC (\027\024\r\024\n \007\036\005\f\021\r\017\017 \215\230\206\030\215 )Tj 0.119 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\020\030\036\f\f\017\030\024\r\026\027\017\036 \025\217\217 \ \f)Tj /Span<>> BDC ( )Tj EMC (\031\004\026\f\021\017\036\n \n\017\022\030\024\024\022\030\031\032\036)Tj 0 Tw (-)Tj 0.143 Tw T* (\027\017\016 \r)Tj /Span<>> BDC ( )Tj EMC (\n\024\007\031\035\016\006\017\017 \f\024\002\t\021\017\005, \f\r\016\026\ \027\027\t\b \f)Tj /Span<>> BDC ( )Tj EMC (\224\204\215. \230\026\022\032\036 )Tj 0.244 Tw T* (\023\024\022\026\026\027\024, \004\021\024 \022\035\033\004\036\r\t\036\ \n\024\035\036\022\031\035\016\030\027\t\036 \n\036\b\026\027\017\n\t,\ )Tj 0.022 Tw 23.244 64.543 Td (\f\r\016\026\027\027\t\036 \f)Tj /Span<>> BDC ( )Tj EMC (\224\204\215, \027\026\002\035\033\007\026\036\n\024\005 \r)Tj /Span<>> BDC ( )Tj EMC [(\220\021\024\005 \022\035\036\021\024\004\027\024\005 )0.5(\035\017)]TJ 0 Tw (-)Tj 0.097 Tw T* (\027\017\017 \r)Tj /Span<>> BDC ( )Tj EMC (\024\021\r\036\021 \027\026)Tj /Span<>> BDC ( )Tj EMC (\215\230\206\030\215, \027\036 \002\t\035\017 \024\002\027\026\030\031\032\ \036\027\t \r)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\036\036 )Tj 0.112 Tw T* (\007\017\235\235\036\030\036\027\006\017\030\024\r\026\027\027\t\b \017)Tj /Span<>> BDC ( )Tj EMC (\n\036\027\036\036 \026\020\030\036\f\f\017\r\027\t\b \022\035\036\021\022\ \026\b )Tj 0.01 Tw T* [(Ca)-17(co-2. \217\026\027\017\006\026 \r)]TJ /Span<>> BDC ( )Tj EMC (\024\021\r\036\021\036 \024\002\036\017\b \022\035\036\021\024\004\027\t\ \b \035\017\027\017\005, \023\024)Tj 0 Tw (-)Tj 0.034 Tw T* (\035\031\004\036\027\027\t\b \017)Tj /Span<>> BDC ( )Tj EMC (\025\217\217, \031\022\026\t\r\026\036\021 \027\026)Tj /Span<>> BDC ( )Tj EMC (\027\024\r\t\005 \n\036\b\026\027\017\n \007\036\005)Tj 0 Tw (-)Tj 0.169 Tw T* [(\f\021\r\017\016 )0.6(\215\230\206\030\215, )0.5(\020\007\036 )0.5(\036\020\024 )0.5(\220\235\235\036\022\021 )0.6(\026\r\017\f\017\021 )0.5(\024\021 )0.5(\030\026\035\017\004\027\024\005 )]TJ 0 Tw 0 -1.218 TD (\026\020\030\036\f\f\017\r\027\024\f\021\017 \022\035\036\021\024\004\027\ \024\005 \035\017\027\017\017.)Tj 0.041 Tw 0 -1.218 TD [(\217\036\031\035\034\021\026\021\t )0.6(\017\f\f\035\036\007\024\r\026\027\017\016 )0.6(\021\026\022\032\036 )0.5(\023\024\022\026\026\035\017, )0.5(\004\021\024 )0.6(\215\230\206\030\215 )]TJ 0.326 Tw T* (\023\026\030\026\022\030\017\027\027\t\n \024\002\030\026\024\n \031\004\ \026\f\021\r\031\036\021 \r)Tj /Span<>> BDC ( )Tj EMC (\f\024\002\t\021\017\016\b, \f\r\016)Tj 0 Tw (-)Tj 0.167 Tw T* (\026\027\027\t\b \f)Tj /Span<>> BDC ( )Tj EMC (\026\020\030\036\f\f\017\r\027\t\n \023\024\r\036\007\036\027\017\036\n \ \022\035\036\021\024\022 \025\217\217. \230\024\021 )Tj 0.212 Tw T* (\235\026\022\021, \004\021\024 \220\021\024\021 \006\017\021\024\022\017\ \027 \031\f\021\026\027\026\r\035\017\r\026\036\021 \f\r\016\034 \n\036\ \032\007\031 )Tj 0.329 Tw T* [(\022\035\036\021\022\026\n\017 )0.5(\025\217\217 )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC [(\220\027\007\024\021\036\035\017\026\035\034\027\t\n\017 )0.5(\022\035\036\021\022\026\n\017 )0.5(HMEC )]TJ 0.09 Tw 0 -1.218 TD [(\004\036\030\036 \n\024\035\036\022\031\035\016\030\027\t\036 )0.5(\235\026\022\021\024\030\t, \f\023\024\f\024\002\f\021\r\031\033\013\017\ \036 \024\023\031)]TJ 0 Tw (-)Tj 0.116 Tw 0 -1.218 TD (\b\024\035\036\026\f\f\024\006\017\017\030\024\r\026\027\027\024\n\031 \026\ \027\020\017\024\020\036\027\036\031, \016\r\017\035\f\016 \024\f\027\024\ \r\026)Tj 0 Tw (-)Tj 0.079 Tw 0 -1.218 TD (\027\017\036\n \007\035\016 \026\027\026\035\017\026 \021\024\020\024, \ \022\026\022 \215\230\206\030\215 \f\023\024\f\024\002\f\021\r\031\036\021\ \r\026)Tj 0 Tw (-)Tj 0.071 Tw T* (\017\n\024\007\036\005\f\021\r\017\033 \n\036\032\007\031 \024\023\031\b\ \024\035\036\r\024\005 \022\035\036\021\022\024\005 \017)Tj /Span<>> BDC ( )Tj EMC (\022\035\036\021\022\026\n\017 )Tj 0 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC 1.177 0 Td [(\036\036 )0.5(\n\017\022\030\024\024\022\030\031\032\036\027\017\016. )0.6(\200)]TJ /Span<>> BDC ( )Tj EMC 9.559 0 Td [(\027\036\007\026\r\027\036\005 )0.6(\030\026\002\024\021\036 )0.5(\002\t\035\024 )0.5(\023\030\024)]TJ (-)Tj 0.067 Tw -10.737 -1.218 Td (\007\036\n\024\027\f\021\030\017\030\024\r\026\027\024, \004\021\024 \220\ \021\024\021 \006\017\021\024\022\017\027 \007\036\005\f\021\r\031\036\021\ \027\026)Tj /Span<>> BDC ( )Tj EMC (\220\027)Tj 0 Tw (-)Tj 0.246 Tw T* (\007\024\021\036\035\017\026\035\034\027\t\036 \022\035\036\021\022\017,\ \f\023\024\f\024\002\f\021\r\031\016 \r\t\f\r\024\002\024\032\007\036\027\ \017\033 )Tj 0.229 Tw T* (\235\026\022\021\024\030\024\r, \022\024\021\024\030\t\036 \r\027\024\f\016\ \021 \r\022\035\026\007 \r)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\020\030\026\n\n\031 \224\204\215 )Tj 0.111 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\022\035\036\021\022\026\b, \023\024\035\031\004\036\027\027\t\b \017)Tj /Span<>> BDC ( )Tj EMC (\025\217\217 [68]. \202\027\026\035\017 \r\035\017\016\027\017\016 )Tj 0.012 Tw T* (\215\230\206\030\215 \027\026)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\020\030\026\n\n\031 \224\204\215, \026)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\032\036 \007\030\031\020\017\036 \023\030\024\020\030\026\n\ \n\t, )Tj 0.147 Tw T* (\f\r\016\026\027\027\t\036 \f\024 \035\024\022\026\004\036\f\021\r\036\ \027\027\t\n \023\030\024\020\030\036\f\f\017\030\024\r\026\027\017\036\n\ , )Tj -0.049 Tw T* [(\r\022\035\033\004\026\016 )0.6(\017\027\017\006\017\026\006\017\033 )0.5(\030\026\022\024\r\t\b )0.6(\f\021\r\024\035\024\r\t\b )0.5(\022\035\036\021\024\022 )0.5(\(\217\221\025\), )]TJ 0.006 Tw T* (\f\r\017\007\036\021\036\035\034\f\021\r\031\036\021 \024)Tj /Span<>> BDC ( )Tj EMC (\021\024\n, \004\021\024 \023\030\024\020\030\026\n\n\026 \224\204\215 \021\ \036\f\027\024 \f\r\016)Tj 0 Tw (-)Tj 0.275 Tw T* (\026\027\026 \f)Tj /Span<>> BDC ( )Tj EMC (\235\036\027\024\021\017\023\024\n \217\221\025, \030\036\020\031\035\017\ \030\031\016 \017\b \024\f\024\002\036\027\027\024\f\021\017 )Tj 0.002 Tw T* ([9]. \200)Tj /Span<>> BDC ( )Tj EMC (\022\035\036\021\022\026\b, \023\024\035\031\004\036\027\027\t\b \017)Tj /Span<>> BDC ( )Tj EMC (\025\217\217, \215\230\206\030\215 \n\024\007\031\035\017\030\031\036\021\ )Tj 0.072 Tw T* [(\220\022\f\023\030\036\f\f\017\033 \002\036\035\022\026 )0.5(\n\026\030\022\036\030\024\r \022\035\036\021\024\004\027\024\005 \023\024\ \r\036\030\b\027\024\f\021\017, )]TJ 0.151 Tw T* [(\001\017\030\024\022\024 \f\r\016\026\027\027\t\b )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC 9.094 0 Td [(\217\221\025 )0.5(\021\024\035\f\021\024\005 \022\017\001\022\017, )0.5(\r\024\n\024\032\027\024, )]TJ 0.199 Tw -9.094 -1.218 Td [(\031\004\026\f\021\r\031\016 )0.6(\r)]TJ /Span<>> BDC ( )Tj EMC 4.923 0 Td [(\017\027\017\006\017\026\006\017\017 )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC 5.961 0 Td [(\030\036\023\030\024\020\030\026\n\n\017\030\024\r\026\027\017\017 )0.6(\220\021\024\005 )]TJ 0.165 Tw -10.884 -1.218 Td (\022\035\036\021\024\004\027\024\005 \f\031\002\023\024\023\031\035\016\006\ \017\017. \211\004\017\021\t\r\026\016 \r\f\036 \220\021\017 \030\036\031\ \035\034)Tj 0 Tw (-)Tj 0.262 Tw T* (\021\026\021\t, \026\r\021\024\030\t \022\024\027\f\021\026\021\017\030\024\ \r\026\035\017, \004\021\024 \215\230\206\030\215 \031\004\026\f\021\r\031\ \036\021 )Tj -0.003 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC [(\n\024\007\031\035\016\006\017\017 )0.5(\027\036\f\022\024\035\034\022\017\b )0.5(\f\024\002\t\021\017\005, \f\r\016\026\027\027\t\b )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC (\026\020\030\036\f)Tj 0 Tw (-)Tj 0.03 Tw T* (\f\017\r\027\t\n \235\036\027\024\021\017\023\024\n \022\024\035\024\030\ \036\022\021\026\035\034\027\t\b \024\023\031\b\024\035\036\r\t\b \022\035\ \036)Tj 0 Tw (-)Tj -0.008 Tw T* (\021\024\022. \212\036\005\f\021\r\017\036 \026\031\021\024\022\030\017\027\ \027\t\b \017)Tj /Span<>> BDC ( )Tj EMC (\023\026\030\026\022\030\017\027\027\t\b \235\026\022\021\024\030\024\r,\ )Tj 0.158 Tw T* (\023\030\024\017\f\b\024\007\016\013\017\b \017)Tj /Span<>> BDC ( )Tj EMC (\024\023\031\b\024\035\017 \017)Tj /Span<>> BDC ( )Tj EMC (\017\b \f\021\030\024\n\t, \n\024\032\036\021 \f\023\024)Tj 0 Tw (-)Tj 0.072 Tw T* (\f\024\002\f\021\r\024\r\026\021\034 \030\016\007\031 \f\024\002\t\021\017\ \005, \f\023\024\f\024\002\f\021\r\031\033\013\017\b \235\036\027\024\021\ \017)Tj 0 Tw (-)Tj -0.006 Tw T* (\023\017\004\036\f\022\024\005 \017)Tj /Span<>> BDC ( )Tj EMC (\020\036\027\036\021\017\004\036\f\022\024\005 \020\036\021\036\030\024\020\ \036\027\027\024\f\021\017 \024\023\031\b\024\035\036\r\t\b )Tj 0.209 Tw T* (\022\035\036\021\024\022, \r\035\017\016\033\013\017\b \027\026)Tj /Span<>> BDC ( )Tj EMC (\220\235\235\036\022\021\017\r\027\024\f\021\034 \017\f\023\024\035\034\ \031\036\n\t\b )Tj 0 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\027\026\f\021\024\016\013\036\036 \r\030\036\n\016 \n\036\021\024\007\024\ \r \035\036\004\036\027\017\016.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 303.3769 213.3538 Tm [(\020)21(\026\027\r\242\224\034\022\031\034)]TJ 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0 Tc 0.083 Tw 10 0 0 10 303.3071 188.9978 Tm (\215\230\206\030\215 \r)Tj /Span<>> BDC ( )Tj EMC [(\022\035\036\021\022\026\b \025\217\217 \f\023\024\f\024\002\f\021\r\031\ \036\021 \r\t\032\017\r\026\027\017\033, )0.5(\023\030\024)]TJ 0 Tw (-)Tj 0.49 Tw T* (\020\030\036\f\f\017\030\024\r\026\027\017\033 \022\035\036\021\024\004\027\ \024\020\024 \006\017\022\035\026, \023\030\024\035\017\235\036\030\026\006\ \017\017, )Tj 0.019 Tw T* (\n\017\020\030\026\006\017\017 \017)Tj /Span<>> BDC ( )Tj EMC (\b\017\n\017\024\030\036\017\f\021\036\027\021\027\024\f\021\017, \026)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\032\036 \n\024\007\031\035\017\030\031)Tj 0 Tw (-)Tj -0.038 Tw T* (\036\021 \220\022\f\023\030\036\f\f\017\033 \n\026\030\022\036\030\024\r\ , \f\r\016\026\027\027\t\b \f)Tj /Span<>> BDC ( )Tj EMC (\017\027\r\026\017\036\005, \026\027\020\017)Tj 0 Tw (-)Tj 0.024 Tw T* (\024\020\036\027\036\024\n, \023\036\030\036\b\024\007\024\n \024\021 \220\ \023\017\021\036\035\017\016 \022)Tj /Span<>> BDC ( )Tj EMC (\n\036\036\027\b\017\n\036 \017)Tj /Span<>> BDC ( )Tj EMC (\024\f\024)Tj 0 Tw (-)Tj 0.171 Tw T* (\002\036\027\027\024\f\021\017 \030\026\022\024\r\t\b \f\021\r\024\035\024\ \r\t\b \022\035\036\021\024\022. \215\024\022\026\026\027\024, \004\021\ \024 )Tj 0.258 Tw T* (\r\r\036\007\036\027\017\036 \215\230\206\030\215 \031\r\036\035\017\004\ \017\r\026\036\021 \220\022\f\023\030\036\f\f\017\033 \027\036\f\022\024\ \035\034)Tj 0 Tw (-)Tj 0.051 Tw T* (\022\017\b \n\026\030\022\036\030\024\r, \f\r\016\026\027\027\t\b \f)Tj /Span<>> BDC ( )Tj EMC (\024\027\022\024\020\036\027\027\t\n\017 \f\024\002\t\021\017\016\n\017.\ )Tj 0.154 Tw T* (\211\f\021\026\027\024\r\035\036\027\t \235\026\022\021\t, \f\r\017\007\036\ \021\036\035\034\f\021\r\031\033\013\017\036 \024\002 \031\004\026\f\021\ \017\017 )Tj 0.211 Tw T* (\215\230\206\030\215 \r)Tj /Span<>> BDC ( )Tj EMC (\023\030\017\024\002\030\036\021\036\027\017\017 \022\035\036\021\022\026\ \n\017 \025\217\217 \026\020\030\036\f\f\017\r\027\024\020\024 )Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 0 Tw 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\214)10(\211\036\033 \035\030\032\t\033)30(\b)42(\032)-21(\240\033\233)]TJ 57.136 0 Td (REVIEW)Tj -57.136 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 23, \023\0221)69(, 202)69(4)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 23, \023\0221)69(, 202)69(4)]TJ /T1_5 1 Tf 25 0 0 25 20.8026 56.0378 Tm (168)Tj ET endstream endobj 328 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\037)31(\025\007\025\002\016\n)-10(\026)11(\013\007\216\001\020\203 \002\013\n, \013\006\006\025\227\220\220\002\025\ \r\013\001\001\020\203 \006\022\221\013\002\013\026\202)10(\025\002\024\025\001-)]TJ 0 -1 TD [(\002\025\201\006)-10(\026\r\016\001\001\020\024 \221\002\025\026)11(\016\220\001\025\024 \(\025\f\222\025\002 \007\220\026)11(\016\002\013\026)-19.9(\215\002\020\))]TJ 42.257 1 Td [(Color)31(ectal cancer associated with par)21(ath)31(yr)20(oid )]TJ 4.983 -1 Td [(h)11(ormone)-52(-r)31.1(elated pr)20(otein \(r)31(e)11(vie)11(w\))]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0.102 Tw 10 0 0 10 42.5197 724.8299 Tm (\b\017\n\017\024\030\036\017\f\021\036\027\021\027\024\f\021\017 \022)Tj /Span<>> BDC ( )Tj EMC (\023\030\036\023\026\030\026\021\026\n, \024\002\t\004\027\024 \017\f\023\ \024\035\034)Tj 0 Tw (-)Tj 0.197 Tw 0 -1.218 TD (\031\036\n\t\n \r)Tj /Span<>> BDC ( )Tj EMC [(\021\036\030\026\023\017\017 \025\217\217 [44]. \212\035\016 \023\024\035\ \031\004\036\027\017\016 )0.5(\024\021\r\036\021\026 )]TJ 0.22 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC (\r\024\023\030\024\f \n\024\032\036\021 \035\017 \215\230\206\030\215 \002\ \t\021\034 \024\f\027\024\r\027\t\n \235\026\022\021\024)Tj 0 Tw (-)Tj 0.431 Tw T* (\030\024\n \027\026\002\035\033\007\026\036\n\024\005 \b\017\n\017\024\030\ \036\017\f\021\036\027\021\027\024\f\021\017 \022)Tj /Span<>> BDC ( )Tj EMC (CPT-11 )Tj 0.38 Tw T* [(\022\035\036\021\024\004\027\t\036 \035\017\027\017\017 Ca)-16.9(co-2 \017)]TJ /Span<>> BDC ( )Tj EMC (HCT116 \024\002\030\026\002\026\021\t\r\026\035\017 )Tj 0.188 Tw T* (\215\230\206\030\215 \f)Tj /Span<>> BDC ( )Tj EMC [(\023\024\f\035\036\007\031\033\013\017\n )0.5(\r\024\007\036\005\f\021\r\017\036\n \017\030\017\027\024\021\036\022\026\ \027\024\n )]TJ -0.021 Tw 0 -1.218 TD (\(10)Tj /Span<>> BDC ( )Tj EMC (\n\022\204\). \202\r\021\024\030\t \024\002\027\026\030\031\032\017\035\017\ , \004\021\024 \220\022\024\020\036\027\027\024\036 \007\024\002\026\r)Tj 0 Tw (-)Tj 0.062 Tw 0 -1.218 TD (\035\036\027\017\036 \215\230\206\030\215 \024\f\035\026\002)Tj /Span<>> BDC ( )Tj EMC 8.008 0 Td (\035\016\035\024 \220\235\235\036\022\021 \006\017\021\024\f\021\026\021\ \017\022\026 \r)Tj /Span<>> BDC ( )Tj EMC (\024\002\036\017\b )Tj 0.143 Tw -8.008 -1.218 Td (\022\035\036\021\024\004\027\t\b \035\017\027\017\016\b. \224\021\017 \030\ \036\031\035\034\021\026\021\t \023\024\r\024\035\017\035\017 \023\030\ \036\007)Tj 0 Tw (-)Tj 0.154 Tw T* (\023\024\035\024\032\017\021\034, \004\021\024 \215\230\206\030\215 \f\023\ \024\f\024\002\f\021\r\031\036\021 \b\017\n\017\024\030\036\017\f\021\036\ \027\021)Tj 0 Tw (-)Tj 0.148 Tw T* (\027\024\f\021\017 \022\035\036\021\024\022 \025\217\217 \022)Tj /Span<>> BDC ( )Tj EMC (\017\030\017\027\024\021\036\022\026\027\031 [44]. \210\021\r\036\021 \024\ \023\031\b\024)Tj 0 Tw (-)Tj 0.054 Tw T* (\035\036\r\t\b \022\035\036\021\024\022 \027\026)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\021 \023\030\036\023\026\030\026\021 \023\024\007 \007\036\005\ \f\021\r\017\036\n \215\230\206\030\215 )Tj 0.166 Tw 0 -1.218 TD (\r\022\035\033\004\026\036\021 \f\017\020\027\026\035\034\027\t\005 \023\ \031\021\034 ERK [33]. \222\f\f\035\036\007\024\r\026\027\017\016, )Tj 0.182 Tw 0 -1.218 TD [(\023\030\024\r\036\007\036\027\027\t\036 P)40(aill)-16(as)]TJ /Span<>> BDC ( )Tj EMC (S. \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. [53], \023\024\022\026\026\035\017, \004\021\024 )Tj 0.195 Tw 0 -1.218 TD [(\023\031\021\034 )0.5(p38 )0.5(MAPK )0.6(\021\026\022\032\036 )0.5(\n\024\007\031\035\017\030\031\036\021 )0.6(\004\031\r\f\021\r\017\021\036\035\034\027\024\f\021\034 )]TJ 0.317 Tw T* (\022\035\036\021\024\022 \025\217\217 \022)Tj /Span<>> BDC ( )Tj EMC (\017\030\017\027\024\021\036\022\026\027\031. \212\030\031\020\017\036 \017\ \f\f\035\036\007\024\r\026\021\036\035\017 )Tj 0.083 Tw T* (\f\024\024\002\013\017\035\017, \004\021\024 \026\022\021\017\r\026\006\017\ \016 ERK 1/2 MAPK \r)Tj /Span<>> BDC ( )Tj EMC (\022\035\036\021\024\004\027\024\005 )Tj 0.092 Tw T* (\035\017\027\017\017 HCT116 \n\024\032\036\021 \r\t\t\r\026\021\034 \031\ \f\021\024\005\004\017\r\024\f\021\034 \017)Tj /Span<>> BDC ( )Tj EMC (\022)Tj /Span<>> BDC ( )Tj EMC (\024\022)Tj 0 Tw (-)Tj T* (\f\026\035\017\023\035\026\021\017\027\031 [54].)Tj 0.242 Tw T* (\212\024\022\f\024\030\031\002\017\006\017\027)Tj /Span<>> BDC ( )Tj EMC (\227 \036\013\036 \024\007\017\027 \b\017\n\017\024\021\036\030\026\023\036\ \r\021\017\004\036\f\022\017\005 )Tj 0.001 Tw T* (\026\020\036\027\021, \022\024\021\024\030\t\005 \002\t\035 \220\235\235\ \036\022\021\017\r\036\027 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\035\036\004\036\027\017\017 \030\026\f\023\030\024)Tj 0 Tw (-)Tj -0.032 Tw T* (\f\021\030\026\027\036\027\027\024\020\024 \025\217\217. \210\007\027\026\ \022\024 \023\024\002\024\004\027\t\036 \220\235\235\036\022\021\t, \f\r\ \016\026\027)Tj 0 Tw (-)Tj 0.071 Tw T* (\027\t\036 \f)Tj /Span<>> BDC ( )Tj EMC (\036\020\024 \023\030\017\n\036\027\036\027\017\036\n \r)Tj /Span<>> BDC ( )Tj EMC (\r\t\f\024\022\017\b \007\024\026\b, \017)Tj /Span<>> BDC ( )Tj EMC (\030\026\r\017\021\017\036 )Tj -0.042 Tw T* [(\b\017\n\017\024\030\036\017\f\021\036\027\021\027\024\f\021\017 )0.6(\023\030\036\007\f\021\026\r\035\016\033\021 )0.6(\f\024\002\024\005 )0.5(\f\036\030\034\036\027\031\033 )]TJ 0.167 Tw T* [(\023\030\024\002\035\036\n\031 )0.5(\007\035\016 )0.6(\220\235\235\036\022\021\017\r\027\024\020\024 )0.6(\035\036\004\036\027\017\016 )0.6([55,56]. )0.5(\207\t\035\024 )]TJ -0.008 Tw T* (\023\024\022\026\026\027\024, \004\021\024 \024\002\030\026\002\024\021\ \022\026 \022\035\036\021\024\022 HCT116 \215\230\206\030\215 \024\f\035\ \026\002)Tj /Span<>> BDC (-)Tj EMC 0.227 Tw T* (\035\016\035\026 \006\017\021\024\021\024\022\f\017\004\027\024\f\021\034\ , \017\027\007\031\006\017\030\024\r\026\027\027\031\033 \024\022\f\026\035\ \017\023\035\026)Tj 0 Tw (-)Tj 0.182 Tw T* (\021\017\027\024\n \017)Tj /Span<>> BDC ( )Tj EMC (\007\024\022\f\024\030\031\002\017\006\017\027\024\n. \224\021\024 \031\022\ \026\t\r\026\036\021 \027\026)Tj /Span<>> BDC ( )Tj EMC (\021\024, \004\021\024 )Tj -0.028 Tw T* [(\215\230\206\030\215 )0.5(\f\023\024\f\024\002\f\021\r\031\036\021 )0.6(\031\f\021\024\005\004\017\r\024\f\021\017 )0.6(\022)]TJ /Span<>> BDC ( )Tj EMC 14.92 0 Td [(\030\026\035\017\004\027\t\n )0.6(\021\017\023\026\n )]TJ 0.076 Tw -14.92 -1.218 Td (\006\017\021\024\021\024\022\f\017\004\036\f\022\017\b \026\020\036\027\021\ \024\r. \200\024\n\024\032\027\024, \n\036\b\026\027\017\n\t, \026)Tj 0 Tw (-)Tj 0.206 Tw T* (\023\031\f\022\026\036\n\t\036 \220\021\017\n \006\017\021\024\022\017\027\ \024\n, \017\n\036\027\016\033\021 \f\023\036\006\017\235\017\004\036\f\ )Tj 0 Tw (-)Tj T* (\022\017\036 \n\017\001\036\027\017 \017\035\017 \023\036\030\036\007\026\ \004\031 \f\017\020\027\026\035\024\r \220\021\017\b \023\030\036\023\026\ \030\026\021\024\r.)Tj 0.245 Tw T* (\200 \023\024\f\035\036\007\031\033\013\036\n \017\f\f\035\036\007\024\r\ \026\027\017\017 \002\t\035\024 \023\024\022\026\026\027\024 \031\004\026\ )Tj 0 Tw (-)Tj 0.147 Tw T* [(\f\021\017\036 \030\036\006\036\023\021\024\030\027\024\020\024 \023\031\ \021\017 Me)-12(t \r)]TJ /Span<>> BDC ( )Tj EMC (\026\020\030\036\f\f\017\r\027\024\n \023\024\r\036\007\036)Tj 0 Tw (-)Tj 0.249 Tw T* [(\027\017\017 \022\035\036\021\024\022 \025\217\217, \017\027\007\031\006\ \017\030\024\r\026\027\027\024\n \215\230\206\030\215 [57]. Me)-12(t )]TJ 0.419 Tw T* (\023\030\036\007\f\021\026\r\035\016\036\021 \f\024\002\024\005 \030\036\ \006\036\023\021\024\030 \f)Tj /Span<>> BDC ( )Tj EMC (\021\017\030\024\017\027\022\017\027\026\027\024\005 )Tj 0.152 Tw T* (\026\022\021\017\r\027\024\f\021\034\033, \220\022\f\023\030\036\f\f\017\ \030\031\036\021\f\016 \r)Tj /Span<>> BDC ( )Tj EMC (\027\024\030\n\026\035\034\027\t\b \021\022\026\027\016\b )Tj -0.033 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\031\004\026\f\021\r\031\036\021 \r)Tj /Span<>> BDC ( )Tj EMC (\030\026\035\017\004\027\t\b \235\017\017\024\035\024\020\017\004\036\f\ \022\017\b \023\030\024\006\036\f\f\026\b, )Tj -0.011 Tw T* (\021\026\022\017\b \022\026\022 \220\n\002\030\017\024\027\026\035\034\027\ \024\036 \030\026\r\017\021\017\036 \017)Tj /Span<>> BDC ( )Tj EMC (\026\032\017\r\035\036\027\017\036 \030\026\027 )Tj 0.019 Tw T* [([58]. Me)-12(t \026\002\036\030\030\026\027\021\027\024 \026\022\021\017\r\017\030\031\ \036\021\f\016 \023\030\017)]TJ /Span<>> BDC ( )Tj EMC (\n\027\024\020\017\b \021\017\023\026\b )Tj 0.223 Tw T* (\035\024\022\026\004\036\f\021\r\036\027\027\t\b \027\024\r\024\024\002\ \030\026\024\r\026\027\017\005 \004\036\035\024\r\036\022\026, \017)Tj /Span<>> BDC ( )Tj EMC (\036\020\024 )Tj 0.066 Tw T* (\027\036\030\036\020\031\035\017\030\031\036\n\026\016 \026\022\021\017\r\ \027\024\f\021\034 \022\024\030\030\036\035\017\030\031\036\021 \f)Tj /Span<>> BDC ( )Tj EMC (\026\020\030\036\f\f\017\r)Tj 0 Tw (-)Tj 0.212 Tw T* (\027\t\n\017 \023\030\017\027\026\022\026\n\017 \024\023\031\b\024\035\017\ , \021\026\022\017\n\017 \022\026\022 \026\027\024\n\026\035\034\027\026\ \016 )Tj -0.007 Tw T* (\023\030\024\035\017\235\036\030\026\006\017\016 \017)Tj /Span<>> BDC ( )Tj EMC (\r\t\032\017\r\026\036\n\024\f\021\034, \004\021\024 \023\030\017\r\024\007\ \017\021 \022)Tj /Span<>> BDC ( )Tj EMC (\030\024\f\021\031 )Tj 0.319 Tw T* (\024\023\031\b\024\035\017, \035\024\022\026\035\034\027\024\005 \017\027\ \r\026\017\017 \017)Tj /Span<>> BDC ( )Tj EMC (\n\036\021\026\f\021\026\017\030\024\r\026\027\017\033. )Tj 0.134 Tw T* [(\206\017\023\036\030\220\022\f\023\030\036\f\f\017\016 Me)-12(t \017\035\017 \036\020\024 \027\026\030\031\001\036\027\017\036 \030\036\ \020\031\035\016\006\017\017 )]TJ 0.186 Tw T* (\n\024\032\036\021 \023\030\017\r\036\f\021\017 \022)Tj /Span<>> BDC ( )Tj EMC (\035\024\022\026\004\036\f\021\r\036\027\027\024\005 \021\030\026\027\f\ \235\024\030\n\026\006\017\017 )Tj 0.244 Tw T* (\022\035\036\021\024\022 \017)Tj /Span<>> BDC ( )Tj EMC (\f\023\024\f\024\002\f\021\r\031\036\021 \030\026\r\017\021\017\033 \017\ )Tj /Span<>> BDC ( )Tj EMC (\023\030\024\020\030\036\f\f\017\030\024\r\026)Tj 0 Tw (-)Tj 0.307 Tw T* (\027\017\033 \030\026\035\017\004\027\t\b \021\017\023\024\r \030\026\022\ \026, \r\022\035\033\004\026\016 \025\217\217 [59,60]. )Tj 0.165 Tw T* (\207\024\035\036\036 \021\024\020\024, \220\021\024\021 \030\036\006\036\ \023\021\024\030 \f\r\036\030\b\220\022\f\023\030\036\f\f\017\030\031\036\ \021\f\016 \017/)Tj 0.111 Tw T* (\017\035\017 \n\024\032\036\021 \026\002\036\030\030\026\027\021\027\024\ \026\022\021\017\r\017\030\024\r\026\021\034\f\016 \027\036\f\022\024\035\ \034\022\017\n\017 )Tj -0.014 Tw T* (\n\036\b\026\027\017\n\026\n\017 \r)Tj /Span<>> BDC ( )Tj EMC (\022\035\036\021\022\026\b \025\217\217, \r\t\t\r\026\016 \030\026\r\017\ \021\017\036 \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\024)Tj 0 Tw (-)Tj 0.073 Tw T* (\020\030\036\f\f\017\030\024\r\026\027\017\036 \024\023\031\b\024\035\017\ [41,61]. \207\024\035\036\036 \021\024\020\024, \027\026\030\031\001\036\ )Tj 0 Tw (-)Tj 0.188 Tw T* [(\027\017\036 \030\036\020\031\035\016\006\017\017 Me)-12(t \021\026\022\032\036 \f\r\016\026\027\024 \f)]TJ /Span<>> BDC ( )Tj EMC (\035\036\022\026\030\f\021\r\036\027\027\024\005 )Tj 0.457 Tw 23.244 64.543 Td (\031\f\021\024\005\004\017\r\024\f\021\034\033 \022\035\036\021\024\022 \ \030\026\022\026 \021\024\035\f\021\024\005 \022\017\001\022\017 [62]. )Tj 1.332 Tw T* (\203\036\f\022\024\035\034\022\024 \017\f\f\035\036\007\024\r\026\027\017\ \005 \023\030\024\007\036\n\024\027\f\021\030\017\030\024\r\026\035\017 \ )Tj 0.548 Tw T* (\f\r\036\030\b\220\022\f\023\030\036\f\f\017\033 \220\021\024\020\024 \030\ \036\006\036\023\021\024\030\026 \r)Tj /Span<>> BDC ( )Tj EMC (\024\023\031\b\024\035\036\r\024\005 )Tj 0.103 Tw T* (\021\022\026\027\017 \023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\025\217\217. \200)Tj /Span<>> BDC ( )Tj EMC (\f\r\016\017 \f)Tj /Span<>> BDC ( )Tj EMC (\220\021\017\n \017\027\020\017\002\017\030\024\r\026)Tj 0 Tw (-)Tj 0.082 Tw T* [(\027\017\036 Me)-12(t \001\017\030\024\022\024 \017\f\f\035\036\007\031\036\021\f\016 \r)]TJ /Span<>> BDC ( )Tj EMC (\022\026\004\036\f\021\r\036 \007\024\023\024\035\027\036\027\017\016 )Tj 0.287 Tw T* (\022)Tj /Span<>> BDC ( )Tj EMC [(\024\002\t\004\027\024\005 \021\036\030\026\023\017\017 [63,64]. \221\017\ \020\027\026\035\034\027\t\005 \023\031\021\034 Me)-11.9(t, )]TJ 0.205 Tw 0 -1.218 TD [(\017\027\007\031\006\017\030\024\r\026\027\027\t\005 )0.6(\215\230\206\030\215, )0.5(\031\004\026\f\021\r\031\036\021 )0.6(\r)]TJ /Span<>> BDC ( )Tj EMC 16.06 0 Td [(\022\035\036\021\024\004\027\t\b )0.6(\f\024)]TJ 0 Tw (-)Tj -0.01 Tw -16.06 -1.218 Td (\002\t\021\017\016\b, \f\r\016\026\027\027\t\b \f)Tj /Span<>> BDC ( )Tj EMC (\026\020\030\036\f\f\017\r\027\t\n \023\024\r\036\007\036\027\017\036\n \ \022\035\036\021\024\022 )Tj 0.055 Tw 0 -1.218 TD (HCT116 \004\036\035\024\r\036\022\026. \215\230\206\030\215 \024\f\035\026\ \002\035\016\036\021 \006\017\021\024\021\024\022\f\017\004\036\f\022\017\ \005 )Tj 0.056 Tw T* (\220\235\235\036\022\021 \017\030\017\027\024\021\036\022\026\027\026, \024\ \022\f\026\035\017\023\035\026\021\017\027\026 \017\035\017 \007\024\022\ \f\024\030\031\002\017)Tj 0 Tw (-)Tj 0.18 Tw T* (\006\017\027\026 \r)Tj /Span<>> BDC ( )Tj EMC (\022\035\036\021\022\026\b HCT116 \004\036\035\024\r\036\022\026 \004\036\ \030\036 \f\017\020\027\026\035\034\027\t\005 )Tj 0 Tw T* [(\023\031\021\034 Me)-11.9(t.)]TJ 0.118 Tw 0 -1.218 TD (\215\030\036\007\023\024\035\026\020\026\033\021, \004\021\024 \220\022\f\ \023\030\036\f\f\017\016 \017)Tj /Span<>> BDC ( )Tj EMC [(\026\022\021\017\r\027\024\f\021\034 Me)-12(t \030\036)]TJ 0 Tw (-)Tj 0.071 Tw 0 -1.218 TD [(\020\031\035\017\030\031\033\021\f\016 \f\017\020\027\026\035\034\027\t\n\ \017 )0.5(\023\031\021\016\n\017, \026\023\031\f\022\026\036\n\t\n\017 \f\r\016)]TJ 0 Tw (-)Tj 0.176 Tw 0 -1.218 TD (\t\r\026\027\017\036\n \215\230\206\030\215 \f)Tj /Span<>> BDC ( )Tj EMC (\030\036\006\036\023\021\024\030\024\n PTHR1 [57]. \202\r\021\024\030\t \ )Tj 0.183 Tw T* [(\027\026\002\035\033\007\026\035\017, )0.6(\004\021\024 )0.5(\220\022\024\020\036\027\027\t\005 )0.6(\215\230\206\030\215 )0.5(\n\024\007\031\035\017\030\031\036\021 )0.5(\220\022\f)]TJ 0 Tw (-)Tj -0.044 Tw T* [(\023\030\036\f\f\017\033 \002\036\035\022\026 Me)-11.9(t \017)]TJ /Span<>> BDC ( )Tj EMC (\020\036\027\024\r \r)Tj /Span<>> BDC ( )Tj EMC (\022\035\036\021\022\026\b HCT116. \215\030\017)Tj /Span<>> BDC ( )Tj EMC (\025\217\217 )Tj 0.204 Tw T* [(\f\017\020\027\026\035\034\027\t\005 )0.5(\023\031\021\034 Me)-12(t )0.5(\f\r\016\026\027 \f)]TJ /Span<>> BDC ( )Tj EMC [(\220\r\024\035\033\006\017\036\005 )0.5(\024\023\031\b\024\035\017, )]TJ 0.271 Tw T* (\026)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\032\036 \f)Tj /Span<>> BDC ( )Tj EMC (\031\f\021\024\005\004\017\r\024\f\021\034\033 \022)Tj /Span<>> BDC ( )Tj EMC (\b\017\n\017\024\021\036\030\026\023\036\r\021\017\004\036\f\022\017\n )Tj 0.063 Tw T* (\023\030\036\023\026\030\026\021\026\n [59]. \200)Tj /Span<>> BDC ( )Tj EMC (\027\026\f\021\024\016\013\036\036 \r\030\036\n\016 \017\027\020\017\002\ \017\030\024\r\026\027\017\036 )Tj 0.014 Tw T* (\220\021\024\020\024 \030\036\006\036\023\021\024\030\026 \001\017\030\024\ \022\024 \017\031\004\026\036\021\f\016 \r)Tj /Span<>> BDC ( )Tj EMC (\022\026\004\036\f\021\r\036 \007\024\023\024\035)Tj 0 Tw (-)Tj -0.021 Tw T* (\027\017\021\036\035\034\027\024\005 \021\036\030\026\023\017\017 \022)Tj /Span<>> BDC ( )Tj EMC (\021\030\026\007\017\006\017\024\027\027\t\n \n\036\021\024\007\026\n \035\ \036\004\036\027\017\016 )Tj 0.342 Tw T* [(\025\217\217 [63]. \222\f\023\024\035\034\024\r\026\027\017\036 \017\027\ \020\017\002\017\021\024\030\026 \022\017\027\026\t Me)-12(t )]TJ 0.382 Tw T* (SU11274 \r\n\036\f\021\036 \f)Tj /Span<>> BDC ( )Tj EMC (\017\030\017\027\024\021\036\022\026\027\024\n, \024\022\f\026\035\017\023\ \035\026\021\017\027\024\n )Tj 0.159 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC [(\007\024\022\f\024\030\031\002\017\006\017\027\024\n \023\024\r\t\001\026\ \036\021 \004\031\r\f\021\r\017\021\036\035\034\027\024\f\021\034 )0.5(\022\035\036)]TJ 0 Tw (-)Tj 0.156 Tw T* (\021\024\022 \025\217\217 \022)Tj /Span<>> BDC ( )Tj EMC (\220\021\017\n \023\030\036\023\026\030\026\021\026\n, \004\021\024 \f\r\ \017\007\036\021\036\035\034\f\021\r\031\036\021 \024\002 )Tj 0.252 Tw T* [(\031\004\026\f\021\017\017 Me)-12(t \r)]TJ /Span<>> BDC ( )Tj EMC (\b\017\n\017\024\030\036\017\f\021\036\027\021\027\024\f\021\017, \017\027\ \007\031\006\017\030\024\r\026\027)Tj 0 Tw (-)Tj 0.11 Tw T* [(\027\024\005 \215\230\206\030\215. SU11274 \023\030\036\007\024\021\r\030\ \026\013\026\036\021 \026\022\021\017\r\026\006\017\033 Me)-12(t, )]TJ 0.071 Tw T* [(\023\024\f\022\024\035\034\022\031 )0.5(\016\r\035\016\036\021\f\016 )0.5(\022\024\027\022\031\030\036\027\021\027\t\n )0.5(\202\230\205-\017\027\020\017\002\017\021\024\030\024\n )]TJ -0.059 Tw T* [(\022\026\021\026\035\017\021\017\004\036\f\022\024\005 \026\022\021\017\r\ \027\024\f\021\017 Me)-12(t [65]. \230\024\021 \235\026\022\021, \004\021\024 \024\002)]TJ 0 Tw (-)Tj -0.056 Tw T* [(\027\026\030\031\032\036\027\024 )0.5(\027\026\004\017\021\036\035\034\027\024\036 )0.5(\f\027\017\032\036\027\017\036 \032\017\027\036\f\023\024\f\024\002\027\ \024\f\021\017 )]TJ 0.012 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\n\017\020\030\026\006\017\017 \022\035\036\021\024\022 HCT116 \r)Tj /Span<>> BDC ( )Tj EMC (\023\030\017\f\031\021\f\021\r\017\017 \017\027\020\017\002\017\021\024\030\ \026 )Tj 0.11 Tw T* [(Me)-12(t, \026)]TJ /Span<>> BDC ( )Tj EMC (\021\026\022\032\036 \024\002\030\026\013\036\027\017\036 \017\027\007\031\ \022\006\017\017 \n\036\036\027\b\017\n\026\035\034\027\024\020\024 )Tj -0.03 Tw T* [(\235\036\027\024\021\017\023\026 )0.6(\007\026\032\036 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 7.17 0 Td [(\023\030\017\f\031\021\f\021\r\017\017 )0.6(\215\230\206\030\215, )0.5(\031\022\026\t\r\026\036\021 )0.5(\027\026)]TJ /Span<>> BDC ( )Tj EMC 13.875 0 Td (\021\024, )Tj 0.069 Tw -21.045 -1.218 Td [(\004\021\024 Me)-12(t \r)]TJ /Span<>> BDC ( )Tj EMC (\024\f\027\024\r\027\024\n \031\004\026\f\021\r\031\036\021 \r)Tj /Span<>> BDC ( )Tj EMC (\n\024\035\036\022\031\035\016\030\027\t\b \n\036\b\026)Tj 0 Tw (-)Tj 0.021 Tw T* (\027\017\n\026\b, \022\024\021\024\030\t\036 \026\007\036\005\f\021\r\024\ \r\026\027\t \r)Tj /Span<>> BDC ( )Tj EMC (\220\021\017\b \022\035\036\021\024\004\027\t\b \024\021)Tj 0 Tw (-)Tj 0.121 Tw T* (\r\036\021\026\b \027\026)Tj /Span<>> BDC ( )Tj EMC (\007\036\005\f\021\r\017\036 \215\230\206\030\215. \222\f\f\035\036\007\024\ \r\026\027\017\016 )Tj /T1_2 1 Tf (in)Tj /Span<>> BDC ( )Tj EMC (vitro)Tj /T1_1 1 Tf ( \023\024)Tj 0 Tw (-)Tj 0.406 Tw T* (\r\024\035\017\035\017 \023\030\036\007\023\024\035\024\032\017\021\034\ \f\031\013\036\f\021\r\024\r\026\027\017\036 \n\036\b\026\027\017\n\026\ , )Tj 0.159 Tw T* (\024\f\027\024\r\026\027\027\024\020\024 \027\026)Tj /Span<>> BDC ( )Tj EMC (\007\036\005\f\021\r\017\017 \215\230\206\030\215 \027\026)Tj /Span<>> BDC ( )Tj EMC (\030\036\020\031\035\016\006\017\033 \220\022\f)Tj 0 Tw (-)Tj 0.025 Tw T* [(\023\030\036\f\f\017\017 \020\036\027\026 Me)-12(t , \026)]TJ /Span<>> BDC ( )Tj EMC (\021\026\022\032\036 \027\026)Tj /Span<>> BDC ( )Tj EMC (\036\020\024 \026\022\021\017\r\026\006\017\033 \023\024\f\030\036\007)Tj 0 Tw (-)Tj -0.019 Tw T* [(\f\021\r\024\n \022\017\027\026\t Sr)-31.9(c \017)]TJ /Span<>> BDC ( )Tj EMC [(\023\031\021\017 MAPK)25(s [57]. \215\024\f\035\036 \026\022\021\017\r\026\006\017\017 )]TJ 0.291 Tw T* [(\023\036\030\036\007\026\004\026 \f\017\020\027\026\035\024\r Me)-12(t \023\030\017\r\024\007\017\021 \022)]TJ /Span<>> BDC ( )Tj EMC (\n\024\035\036\022\031\035\016\030\027\t\n )Tj 0.085 Tw T* [(\017\n\036\027\036\027\017\016\n )0.6(\r)]TJ /Span<>> BDC ( )Tj EMC 6.142 0 Td [(\024\023\031\b\024\035\036\r\t\b )0.6(\022\035\036\021\022\026\b, )0.5(\004\021\024 )0.5(\f\023\024\f\024\002\f\021\r\031\036\021 )]TJ 0.119 Tw -6.142 -1.218 Td (\b\017\n\017\024\030\036\017\f\021\036\027\021\027\024\f\021\017 \022)Tj /Span<>> BDC ( )Tj EMC (\017\030\017\027\024\021\036\022\026\027\031, \024\022\f\026\035\017\023\ \035\026\021\017\027\031 )Tj -0.004 Tw T* (\017\035\017 \007\024\022\f\024\030\031\002\017\006\017\027\031. \200\036\ \030\024\016\021\027\024, \026\022\021\017\r\026\006\017\016 \220\022\f\023\ \030\036\f\f\017\017 )Tj 0.06 Tw T* [(Me)-12(t \021\026\022\032\036 \031\004\026\f\021\r\031\036\021 \r)]TJ /Span<>> BDC ( )Tj EMC (\017\027\007\031\022\006\017\017 \f\024\002\t\021\017\005, \f\r\016\026\ \027\027\t\b )Tj -0.005 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\026\020\030\036\f\f\017\r\027\t\n \023\024\r\036\007\036\027\017\036\n \ \022\035\036\021\024\022 \025\217\217. \203\026)Tj /Span<>> BDC ( )Tj EMC (\f\036\020\024\007\027\016\001)Tj 0 Tw (-)Tj 0.015 Tw T* (\027\017\005 \007\036\027\034 \027\026\002\035\033\007\036\027\017\016 )Tj /T1_2 1 Tf (in vitro)Tj /T1_1 1 Tf ( \023\024\022\026\t\r\026\033\021, \004\021\024 \f\r\016\t)Tj 0 Tw (-)Tj 0.094 Tw T* (\r\026\027\017\036 \215\230\206\030\215 \f)Tj /Span<>> BDC ( )Tj EMC (\036\020\024 \030\036\006\036\023\021\024\030\024\n, PTHR1, \f\023\024\f\ \024\002\f\021\r\031\036\021 )Tj 0.052 Tw T* [(\030\036\020\031\035\016\006\017\017 \220\022\f\023\030\036\f\f\017\017 \ \020\036\027\026 Me)-11.9(t , \026)]TJ /Span<>> BDC ( )Tj EMC (\021\026\022\032\036 \036\020\024 \026\022\021\017\r\026)Tj 0 Tw (-)Tj 0.04 Tw T* [(\006\017\017 \004\036\030\036 \022\017\027\026\031 Sr)-32(c \017)]TJ /Span<>> BDC ( )Tj EMC [(\023\031\021\034 MAPK)25.1(s. \215\024\f\035\036 \026\022\021\017\r\026\006\017\017 )]TJ 0.291 Tw T* [(\023\036\030\036\007\026\004\026 \f\017\020\027\026\035\024\r Me)-12(t \023\030\017\r\024\007\017\021 \022)]TJ /Span<>> BDC ( )Tj EMC (\n\024\035\036\022\031\035\016\030\027\t\n )Tj 0.184 Tw T* [(\017\n\036\027\036\027\017\016\n )0.6(\r)]TJ /Span<>> BDC ( )Tj EMC 6.34 0 Td [(\024\023\031\b\024\035\036\r\t\b )0.6(\022\035\036\021\022\026\b, )0.5(\004\021\024 )0.6(\f\023\024\f\024\002\f\021\r\031)]TJ 0 Tw (-)Tj 0.132 Tw -6.34 -1.218 Td [(\036\021 )0.5(\f\024\002\t\021\017\016\n, )0.6(\f\r\016\026\027\027\t\n )0.6(\f)]TJ /Span<>> BDC ( )Tj EMC 11.409 0 Td [(\026\020\030\036\f\f\017\r\027\t\n )0.6(\023\024\r\036\007\036\027\017\036\n )]TJ 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 0 Tw 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\214)10(\211\036\033 \035\030\032\t\033)30(\b)42(\032)-21(\240\033\233)]TJ 57.136 0 Td (REVIEW)Tj /T1_3 1 Tf 25 0 0 25 505.5644 56.0378 Tm (167)Tj ET endstream endobj 327 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.092 Tw 10 0 0 10 70.8661 724.8299 Tm (\r)Tj /Span<>> BDC ( )Tj EMC (\022\035\036\021\022\026\b, \023\024\035\031\004\036\027\027\t\b \017)Tj /Span<>> BDC ( )Tj EMC (\025\217\217, \016\r\035\016\036\021\f\016 \030\036\031\035\034\021\026\ \021\024\n )Tj 0 Tw 0 -1.218 TD (\r\026\017\n\024\007\036\005\f\021\r\017\016 \215\230\206\030\215/PTHR1\ .)Tj /T1_1 1 Tf 0.323 Tw 0 -2.436 TD (\026\f\t\235\b\t\r \200\020\027\006\200 \b\004)Tj /Span<>> BDC ( )Tj EMC (\004\b\n\t\002\n\r\b\r\213 \220\002\f\002\006\r\220\003\004\f\001\b\002\n\ \002 )Tj 0 Tw 0 -1.218 TD (\006\004\220\004)Tj /T1_0 1 Tf 0.21 Tw T* (\222\r\036\f\021\027\024, \004\021\024 \024\023\031\b\024\035\036\r\t\005\ \026\027\020\017\024\020\036\027\036 \016\r\035\016\036\021\f\016 \024\ \007)Tj 0 Tw (-)Tj 0.223 Tw 0 -1.218 TD (\027\017\n \017)Tj /Span<>> BDC ( )Tj EMC (\024\f\027\024\r\027\t\b \n\036\b\026\027\017\n\024\r, \f)Tj /Span<>> BDC ( )Tj EMC (\023\024\n\024\013\034\033 \022\024\021\024\030\t\b )Tj 0.344 Tw 0 -1.218 TD [(\024\023\031\b\024\035\017 \n\024\020\031\021 \020\036\027\036\030\017\030\ \024\r\026\021\034 )0.5(\022\030\024\r\036\027\024\f\027\t\036 \f\024\f\031\007\t, )]TJ -0.015 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\016\r\035\016\036\021\f\016 \r\026\032\027\t\n \023\030\024\006\036\f\f\ \024\n \007\035\016 \030\024\f\021\026 \017)Tj /Span<>> BDC ( )Tj EMC (\n\036\021\026\f\021\026\017)Tj 0 Tw (-)Tj -0.005 Tw T* (\030\024\r\026\027\017\016 \030\026\022\026, \022\024\021\024\030\t\005 \ \n\024\032\036\021 \r\035\017\016\021\034 \027\026)Tj /Span<>> BDC ( )Tj EMC (\021\036\030\026\023\036\r\021\017\004\036)Tj 0 Tw (-)Tj 0.022 Tw T* (\f\022\031\033 \220\235\235\036\022\021\017\r\027\024\f\021\034. \210\027\ \f\021\030\024\020\024 \030\036\020\031\035\017\030\031\036\021\f\016 \021\ \024\027\022\017\n )Tj 0.184 Tw T* (\002\026\035\026\027\f\024\n \n\036\032\007\031 \023\030\024\026\027\020\ \017\024\020\036\027\027\t\n\017 \017)Tj /Span<>> BDC ( )Tj EMC (\026\027\021\017\026\027\020\017\024\020\036\027)Tj 0 Tw (-)Tj 0.247 Tw 0 -1.218 TD [(\027\t\n\017 )0.5(\235\026\022\021\024\030\026\n\017 )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC 8.696 0 Td [(\n\024\007\031\035\017\030\031\036\021\f\016 )0.6(\030\026\035\017\004\027\t\n\017 )0.5(\f\017\020)]TJ 0 Tw (-)Tj 0.09 Tw -8.696 -1.218 Td (\027\026\035\034\027\t\n\017 \023\031\021\016\n\017. \215\030\017)Tj /Span<>> BDC ( )Tj EMC (\030\026\022\036 \220\021\024\021 \002\026\035\026\027\f \027\026\030\031\ \001\026\036\021\f\016 )Tj 0.064 Tw 0 -1.218 TD (\017-\026 \023\024\r\t\001\036\027\027\024\020\024 \r\t\f\r\024\002\024\ \032\007\036\027\017\016 \023\030\024\026\027\020\017\024\020\036\027\027\ \t\b )Tj 0.021 Tw T* (\235\026\022\021\024\030\024\r, \021\026\022\017\b \022\026\022 \235\026\ \022\021\024\030 \030\024\f\021\026 \220\027\007\024\021\036\035\017\016\ \f\024\f\031\007\024\r )Tj -0.017 Tw T* (\(VEGF\), \022\024\021\024\030\t\036 \023\030\024\007\031\006\017\030\031\ \033\021\f\016 \024\023\031\b\024\035\036\r\t\n\017 \022\035\036\021\022\ \026)Tj 0 Tw (-)Tj 0.041 Tw T* (\n\017 \017)Tj /Span<>> BDC ( )Tj EMC (\n\017\022\030\024\024\022\030\031\032\036\027\017\036\n \024\023\031\b\024\ \035\017, \f\021\017\n\031\035\017\030\031\016 \220\027\007\024\021\036)Tj 0 Tw (-)Tj 0.036 Tw T* (\035\017\026\035\034\027\t\036 \022\035\036\021\022\017 \017)Tj /Span<>> BDC ( )Tj EMC (\f\023\024\f\024\002\f\021\r\031\016 \026\027\020\017\024\020\036\027\036\ \031 \024\023\031\b\024\035\017 )Tj 0.187 Tw T* [([45]. \203\026\030\031\001\036\027\017\036 \220\021\024\020\024 )0.5(\002\026\035\026\027\f\026 \r\035\017\016\036\021 )0.5(\027\026)]TJ /Span<>> BDC ( )Tj EMC (\023\030\024\020\030\036\f)Tj 0 Tw (-)Tj 0.086 Tw T* (\f\017\030\024\r\026\027\017\036 \025\217\217 [46]. \222-\026 \220\021\ \024\020\024 \007\017\f\002\026\035\026\027\f\026 \f\024\f\031\007\t )Tj 0.336 Tw T* (\024\023\031\b\024\035\017 \235\024\030\n\017\030\031\033\021\f\016 \027\ \036 \023\024\035\027\024\f\021\034\033, \026\027\024\n\026\035\034\027\t\ \036, )Tj 0.034 Tw T* (\017\r\017\035\017\f\021\t\036, \027\036\030\036\020\031\035\016\030\027\ \t\036, \030\026\f\001\017\030\036\027\027\t\036 \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\027\017\006\026)Tj 0 Tw (-)Tj 0.02 Tw T* (\036\n\t\036, \017\n\036\033\021 \f\035\026\002\t\036 \f\030\026\013\036\ \027\017\016, \n\026\035\024 \023\036\030\017\006\017\021\024\r \017)Tj /Span<>> BDC ( )Tj EMC (\027\036)Tj 0 Tw (-)Tj -0.02 Tw T* (\023\024\035\027\031\033 \002\026\026\035\034\027\031\033 \n\036\n\002\030\ \026\027\031 \017)Tj /Span<>> BDC ( )Tj EMC (\027\036 \030\026\035\017\004\026\033\021\f\016 \023\024)Tj /Span<>> BDC ( )Tj EMC (\r\036)Tj 0 Tw (-)Tj T* (\027\031\035\026\n, \022\026\023\017\035\035\016\030\026\n \017\035\017 \ \026\030\021\036\030\017\024\035\026\n.)Tj 0.024 Tw T* (\222\r\036\f\021\027\024, \004\021\024 \f\017\020\027\026\035\034\027\t\ \036 \023\031\021\017, \030\036\020\031\035\017\030\031\036\n\t\036 \215\ \230\206\030\215, )Tj 0.13 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\022\035\036\021\024\004\027\t\b \035\017\027\017\016\b, \023\024\035\031\ \004\036\027\027\t\b \017)Tj /Span<>> BDC ( )Tj EMC (\025\217\217, \n\024\020\031\021 \031\004\026)Tj 0 Tw (-)Tj 0.17 Tw T* [(\f\021\r\024\r\026\021\034 )0.6(\r)]TJ /Span<>> BDC ( )Tj EMC 4.827 0 Td [(\026\027\020\017\024\020\036\027\036\036 )0.6([39] )0.6(\(Cal)30(vo )0.6(N. )0.6(e)-12(t )0.6(al., )0.6(2014\). )]TJ 0.049 Tw -4.827 -1.218 Td (\200)Tj /Span<>> BDC ( )Tj EMC [(\027\036\007\026\r\027\036\n \017\f\f\035\036\007\024\r\026\027\017\017 \ Cal)30(vo N. \017)]TJ /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. [47] \017\031)Tj 0 Tw (-)Tj 0.034 Tw T* (\004\017\035\017, \030\036\020\031\035\017\030\031\036\021 \035\017 \215\ \230\206\030\215 \220\022\f\023\030\036\f\f\017\033 \023\030\024\026\027\ \020\017\024\020\036\027)Tj 0 Tw (-)Tj 0.064 Tw T* (\027\t\b \235\026\022\021\024\030\024\r \r)Tj /Span<>> BDC ( )Tj EMC [(\022\035\036\021\024\004\027\t\b \035\017\027\017\016\b Ca)-17(co-2 \017)]TJ /Span<>> BDC ( )Tj EMC (HCT 116, )Tj -0.056 Tw T* (\004\021\024\002\t \024\006\036\027\017\021\034 \r\035\017\016\027\017\036\ \220\021\024\020\024 \006\017\021\024\022\017\027\026 \027\026)Tj /Span<>> BDC ( )Tj EMC (\026\027\020\017\024\020\036\027\036, )Tj 0.043 Tw T* (\f\r\016\026\027\027\t\005 \f)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\020\030\036\f\f\017\036\005 \024\023\031\b\024\035\017. \202\ \r\021\024\030\t \027\026\002\035\033\007\026)Tj 0 Tw (-)Tj 0.084 Tw T* (\035\017, \004\021\024 \215\230\206\030\215 \031\r\036\035\017\004\017\r\ \026\036\021 \031\030\024\r\027\017 \017\027\235\024\030\n\026\006\017\024\ \027\027\024\005 )Tj 0.129 Tw T* (\217\203\025 VEGF, HIF-1\263 \017)Tj /Span<>> BDC ( )Tj EMC (\n\026\021\030\017\022\f\027\024\005 \n\036\021\026\035\035\024\023\030\024\ \021\036\017\027\026\t )Tj 0.107 Tw T* (9 \023\024\f\030\036\007\f\021\r\024\n \f\017\020\027\026\035\034\027\t\b\ \023\031\021\036\005 ERK1/2 \017)Tj /Span<>> BDC ( )Tj EMC [(PI3K/Ak)-24(t )]TJ 0.177 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\024\002\036\017\b \022\035\036\021\024\004\027\t\b \035\017\027\017\016\ \b, \026)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\032\036 \r\t\016\r\017\035\017 \023\024\r\t)Tj 0 Tw (-)Tj 0.05 Tw T* [(\001\036\027\027\t\036 )0.5(\031\030\024\r\027\017 )0.6(VEGF )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 9.742 0 Td [(\024\023\031\b\024\035\016\b )0.5(\022\f\036\027\024\021\030\026\027\f\023\035\026\027\021\026\021\026 )]TJ 0.164 Tw -9.742 -1.218 Td [(HCT116, \024\002\030\026\002\024\021\026\027\027\t\b )0.5(\215\230\206\030\215, )0.5(\023\024)]TJ /Span<>> BDC ( )Tj EMC [(\f\030\026\r\027\036\027\017\033 )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC 20.286 0 Td (\022\024\027)Tj 0 Tw (-)Tj 0.163 Tw -20.286 -1.218 Td (\021\030\024\035\034\027\t\n\017 \024\023\031\b\024\035\016\n\017. \224\021\ \017 \030\036\031\035\034\021\026\021\t \007\024\023\024\035\027\016\035\ \017\f\034 )Tj -0.026 Tw T* (\027\026\035\017\004\017\036\n \022\035\036\021\024\022, \235\024\030\n\017\ \030\031\033\013\017\b \f\021\030\031\022\021\031\030\t \f)Tj /Span<>> BDC ( )Tj EMC (\b\026\030\026\022\021\036)Tj 0 Tw (-)Tj -0.041 Tw T* (\030\017\f\021\017\022\026\n\017 \027\024\r\024\024\002\030\026\024\r\026\ \027\027\t\b \f\024\f\031\007\024\r \017)Tj /Span<>> BDC ( )Tj EMC (\023\024\035\024\032\017\021\036\035\034)Tj 0 Tw (-)Tj -0.01 Tw T* (\027\024 \024\022\030\026\001\036\027\027\t\b \027\026)Tj /Span<>> BDC ( )Tj EMC (\022\035\026\f\021\036\030 \220\027\007\024\021\036\035\017\026\035\034\027\ \t\b \n\026\030\022\036\030\024\r )Tj 0.325 Tw T* [(\007\017\235\235\036\030\036\027\006\017\030\024\r\022\017 )0.5(\f\024\f\031\007\024\r [47]. \200\024\n\024\032\027\024\f\021\034 \022\024\ )]TJ 0 Tw (-)Tj 0.122 Tw T* [(\035\017\004\036\f\021\r\036\027\027\024 )0.6(\030\026\035\017\004\026\021\034 )0.5(\027\036\024\r\026\f\022\031\035\016\030\017\026\006\017\033 )0.6(\024\023\031\b\024\035\017 )]TJ -0.057 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC [(\030\026\027\036\036 )0.5(\f\031\013\036\f\021\r\024\r\026\r\001\017\036 \f\024\f\031\007\t )0.5(\r\026\032\027\026, \023\024\f\022\024\035\034\022\031 )0.5(\220\021\017 )]TJ 0.062 Tw T* (\007\026\027\027\t\036 \007\026\033\021 \002\024\035\036\036 \021\024\004\ \027\031\033 \017\027\235\024\030\n\026\006\017\033 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\024\006\036\027\022\036 )Tj 0.108 Tw T* [(\026\027\020\017\024\020\036\027\036\026 )0.5(\024\023\031\b\024\035\017. )0.5(\200)]TJ /Span<>> BDC ( )Tj EMC [(\006\036\035\024\n \220\021\017 )0.5(\030\036\031\035\034\021\026\021\t )0.5(\023\030\036\007)]TJ 0 Tw (-)Tj 0.415 Tw T* (\f\021\026\r\035\016\033\021 \f\024\002\024\005 \023\036\030\r\024\036 \f\ \r\017\007\036\021\036\035\034\f\021\r\024, \f\r\016\026\027\027\024\036\ )Tj 0.311 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\n\036\b\026\027\017\n\024\n \007\036\005\f\021\r\017\016 \215\230\206\030\ \215, \022\024\021\024\030\t\005 \023\030\017\r\024\007\017\021 )Tj 0 Tw T* (\022)Tj /Span<>> BDC ( )Tj EMC (\036\020\024 \023\030\024\026\027\020\017\024\020\036\027\027\t\n \220\235\ \235\036\022\021\026\n \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\025\217\217.)Tj 0.814 Tw T* (\215\030\036\007\f\021\026\r\035\036\027\027\t\036 \030\036\031\035\034\ \021\026\021\t \023\030\036\007\023\024\035\026\020\026\033\021 \r\026)Tj 0 Tw (-)Tj 0.436 Tw T* [(\017\n\024\007\036\005\f\021\r\017\036 )0.6(\n\036\032\007\031 )0.5(\024\023\031\b\024\035\036\r\t\n\017 )0.6(\022\035\036\021\022\026\n\017 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 21.148 0 Td (\017\b )Tj 0.245 Tw 2.096 64.543 Td (\n\017\022\030\024\024\022\030\031\032\036\027\017\036\n \004\036\030\036\  \023\030\024\026\027\020\017\024\020\036\027\027\t\036 \235\026\022\021\ \024\030\t. )Tj 0.183 Tw T* (\200)Tj /Span<>> BDC ( )Tj EMC [(\220\021\024\005 \f\r\016\017 Cal)30(vo N. \017)]TJ /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. [47] \007\024\023\024\035\027\017\021\036\035\034\027\024\ )Tj 0.298 Tw T* (\024\006\036\027\017\035\017 \n\024\035\036\022\031\035\016\030\027\t\036\ \023\036\030\036\022\030\036\f\021\027\t\036 \r\026\017\n\024\f\r\016\ \017 )Tj 0.333 Tw T* (\n\036\032\007\031 \024\023\031\b\024\035\036\r\t\n\017 \022\035\036\021\ \022\026\n\017 \017)Tj /Span<>> BDC ( )Tj EMC (\220\027\007\024\021\036\035\017\026\035\034\027\t\n\017 )Tj 0.324 Tw T* (\022\035\036\021\022\026\n\017. \221)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\005 \006\036\035\034\033 \002\t\035\017 \017\f\023\024\035\034\ \024\r\026\027\t \022\024\027)Tj 0 Tw (-)Tj 0.362 Tw T* [(\007\017\006\017\024\027\017\030\024\r\026\027\027\t\036 \f\030\036\007\t\ \022\035\036\021\024\004\027\t\b \035\017\027\017\005 Ca)-16.9(co-2 )]TJ 0.111 Tw 0 -1.218 TD (\017)Tj /Span<>> BDC ( )Tj EMC [(HCT )0.5(116 \025\217\217, )0.5(\026)]TJ /Span<>> BDC ( )Tj EMC [(\021\026\022\032\036 \r\022\035\033\004\017\035\017 )0.5(\022\035\036\021\024\004\027\031\033 )0.6(\035\017\027\017\033 )]TJ 0.194 Tw 0 -1.218 TD [(HMEC-1 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 4.407 0 Td [(\022\026\004\036\f\021\r\036 )0.5(\n\024\007\036\035\017 )0.6(\220\027\007\024\021\036\035\017\026\035\034\027\t\b )0.6(\022\035\036\021\024\022. )]TJ 0.026 Tw -4.407 -1.218 Td (\211\f\021\026\027\024\r\035\036\027\024, \004\021\024 \022\024\027\007\017\ \006\017\024\027\017\030\024\r\026\027\027\026\016 \f\030\036\007\026 \017\ )Tj /Span<>> BDC ( )Tj EMC (\024\002\036)Tj 0 Tw (-)Tj 0.076 Tw T* (\017\b \022\035\036\021\024\004\027\t\b \035\017\027\017\005 \022\024\035\ \024\030\036\022\021\026\035\034\027\024\020\024 \030\026\022\026, \023\024\ \007\r\036\030\020)Tj 0 Tw (-)Tj 0.164 Tw T* [(\001\017\b\f\016 \r\024\007\036\005\f\021\r\017\033 )0.5(\215\230\206\030\215, \031\r\036\035\017\004\017\r\026\036\021 \022\024\035\ \017\004\036\f\021\r\024 )]TJ 0.057 Tw T* (\022\035\036\021\024\022, \n\017\020\030\026\006\017\033 \017)Tj /Span<>> BDC ( )Tj EMC (\024\002\030\026\024\r\026\027\017\036 \021\030\031\002\004\026\021\t\b\ \f\021\030\031\022\021\031\030 )Tj 0.274 Tw 0 -1.218 TD (\r)Tj /Span<>> BDC ( )Tj EMC (\220\027\007\024\021\036\035\017\026\035\034\027\t\b \022\035\036\021\022\ \026\b HMEC-1, \021\024\020\007\026 \022\026\022 \027\036\005)Tj 0 Tw (-)Tj 0.138 Tw 0 -1.218 TD (\021\030\026\035\017\031\033\013\036\036 \026\027\021\017\021\036\035\024\ \023\030\024\021\017\r VEGF \031\n\036\027\034\001\026\035\024 \220\021\ \024\021 )Tj 0.112 Tw 0 -1.218 TD (\024\021\r\036\021. \025\030\024\n\036 \021\024\020\024, \023\030\036\007\ \r\026\030\017\021\036\035\034\027\026\016 \017\027\022\031\002\026\006\017\ \016 \022\024\027)Tj 0 Tw (-)Tj 0.35 Tw T* [(\007\017\006\017\024\027\017\030\024\r\026\027\027\t\b )0.6(\f\030\036\007 )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC 11.674 0 Td [(\026\027\021\017\021\036\035\024\n )0.6(\023\030\024\021\017\r )0.5(VEGF, )]TJ 0.006 Tw -11.674 -1.218 Td (\031\n\036\027\034\001\026\035\026 \017\b \f\021\017\n\031\035\017\030\031\ \033\013\036\036 \007\036\005\f\021\r\017\036 \027\026)Tj /Span<>> BDC ( )Tj EMC (\220\027\007\024\021\036\035\017)Tj 0 Tw (-)Tj 0.117 Tw T* (\026\035\034\027\t\036 \022\035\036\021\022\017 [47]. \224\021\024 \031\022\ \026\t\r\026\036\021 \027\026)Tj /Span<>> BDC ( )Tj EMC (\021\024, \004\021\024 \215\230\206\030\215 )Tj -0.073 Tw T* (\031\r\036\035\017\004\017\r\026\036\021 \220\022\f\023\030\036\f\f\017\033\ VEGF \r)Tj /Span<>> BDC ( )Tj EMC [(\022\035\036\021\022\026\b Ca)-16.9(co-2 \017)]TJ /Span<>> BDC ( )Tj EMC (\022\035\036\021)Tj 0 Tw (-)Tj 0.362 Tw T* (\022\026\b HCT116 \f)Tj /Span<>> BDC ( )Tj EMC (\023\024\f\035\036\007\031\033\013\017\n \036\020\024 \r\t\f\r\024\002\024\ \032\007\036\027\017\036\n )Tj 0.033 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\022\031\035\034\021\031\030\026\035\034\027\031\033 \f\030\036\007\031.\ \224\021\024\021 \235\026\022\021\024\030, \r)Tj /Span<>> BDC ( )Tj EMC (\f\r\024\033 \024\004\036\030\036\007\034, )Tj -0.003 Tw T* [(\024\022\026\t\r\026\036\021 \023\030\024\026\027\020\017\024\020\036\027\ \027\024\036 )0.5(\007\036\005\f\021\r\017\036 \027\026)]TJ /Span<>> BDC ( )Tj EMC (\220\027\007\024\021\036\035\017\026\035\034)Tj 0 Tw (-)Tj 0.219 Tw T* (\027\t\036 \022\035\036\021\022\017. \224\021\017 \007\026\027\027\t\036\ \030\026\f\001\017\030\017\035\017 \023\030\036\007\f\021\026\r\035\036\ \027\017\016 )Tj 0.172 Tw T* (\024)Tj /Span<>> BDC ( )Tj EMC (\n\036\b\026\027\017\n\036 \007\036\005\f\021\r\017\016 \215\230\206\030\ \215, \021\026\022 \022\026\022 \220\021\024\021 \006\017\021\024\022\017\ \027 )Tj 0.042 Tw T* (\007\036\005\f\021\r\031\036\021 \027\036 \021\024\035\034\022\024 \027\036\ \023\024\f\030\036\007\f\021\r\036\027\027\024 \027\026)Tj /Span<>> BDC ( )Tj EMC (\022\035\036\021\022\017 \025\217\217, )Tj -0.022 Tw T* (\027\024 \017)Tj /Span<>> BDC ( )Tj EMC (\024\022\026\t\r\026\036\021 \f\r\024\017 \220\235\235\036\022\021\t, \r\ \t\f\021\031\023\026\016 \023\024\f\030\036\007\027\017\022\024\n )Tj 0 Tw T* (\n\036\032\007\031 \024\023\031\b\024\035\034\033 \017)Tj /Span<>> BDC ( )Tj EMC (\036\036 \n\017\022\030\024\024\022\030\031\032\036\027\017\036\n.)Tj /T1_1 1 Tf 0.128 Tw 0 -2.436 TD (\223\201\004\217\003\t\r \200\020\027\006\200 )Tj /Span<>> BDC ( )Tj EMC (\226\002\006\214\t\006\002\004\b\t\t \216\t\214\t\002\006\r\213\t\217\003\ \r\b\003)Tj 0 Tw (-)Tj 0.023 Tw 0 -1.218 TD (\b\002\217\003\t \220\f\r\003\002\220 \220\002\f\002\006\r\220\003\004\f\ \001\b\002\n\002 \006\004\220\004)Tj /T1_0 1 Tf 0.09 Tw T* (\200\t\001\036\023\030\017\r\036\007\036\027\027\t\036 \007\026\027\027\t\ \036 \023\030\036\007\023\024\035\026\020\026\033\021, \004\021\024 \215\ \230\206\030\215 )Tj 0.357 Tw T* [(\n\024\032\036\021 )0.5(\031\004\026\f\021\r\024\r\026\021\034 )0.6(\r)]TJ /Span<>> BDC ( )Tj EMC 9.744 0 Td [(\007\030\031\020\017\b )0.5(\f\024\002\t\021\017\016\b, )0.6(\f\r\016\026\027\027\t\b )]TJ -0.013 Tw -9.744 -1.218 Td (\f)Tj /Span<>> BDC ( )Tj EMC [(\023\024\r\036\007\036\027\017\036\n )0.5(\022\035\036\021\024\022 )0.5(\025\217\217. )0.5(\211)]TJ /Span<>> BDC ( )Tj EMC [(\002\024\035\034\001\017\027\f\021\r\026 )0.5(\035\033\007\036\005 )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC 20.72 0 Td (\n\036)Tj 0 Tw (-)Tj 0.275 Tw -20.72 -1.218 Td (\021\026\f\021\026\021\017\004\036\f\022\017\n \025\217\217 \r)Tj /Span<>> BDC ( )Tj EMC (\022\024\027\036\004\027\024\n \017\021\024\020\036 \027\026\002\035\033\ \007\026\036\021\f\016 )Tj 0.091 Tw T* (\022\035\017\027\017\004\036\f\022\026\016 \027\036\031\007\026\004\026 \ \(\021\024 \036\f\021\034 \030\036\006\017\007\017\r \017\035\017 \023\030\ \024\020\030\036\f)Tj 0 Tw (-)Tj 0.279 Tw T* (\f\017\030\024\r\026\027\017\036 \026\002\024\035\036\r\026\027\017\016\ \). \216\017\n\017\024\030\036\017\f\021\036\027\021\027\024\f\021\034 \ \016\r)Tj 0 Tw (-)Tj 0.222 Tw T* (\035\016\036\021\f\016 \004\026\f\021\024\005 \023\030\017\004\017\027\024\ \005 \027\036\220\235\235\036\022\021\017\r\027\024\f\021\017 \035\036\004\ \036\027\017\016 )Tj 0.076 Tw T* (\023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\025\217\217. \210\021\f\031\021\f\021\r\017\036 \024\021\r\036\021\026 \ \027\026)Tj /Span<>> BDC ( )Tj EMC (\035\036\004\036\027\017\036 \023\030\036)Tj 0 Tw (-)Tj 0.179 Tw T* (\023\026\030\026\021\026\n\017 \023\036\030\r\024\005 \035\017\027\017\017\ \007\036\035\026\036\021 \017\b \023\024\021\036\027\006\017\026\035\034\ \027\t\n\017 )Tj 0.195 Tw T* (\022\026\027\007\017\007\026\021\026\n\017 \027\026)Tj /Span<>> BDC ( )Tj EMC (\f\017\f\021\036\n\027\031\033 \021\036\030\026\023\017\033 \r\021\024\030\ \024\005 \035\017\027\017\017. )Tj 0.111 Tw T* (\222\r\036\f\021\027\024, \004\021\024 \r)Tj /Span<>> BDC ( )Tj EMC (\030\026\r\017\021\017\017 \035\036\022\026\030\f\021\r\036\027\027\024\ \005 \031\f\021\024\005\004\017\r\024)Tj 0 Tw (-)Tj -0.035 Tw T* (\f\021\017 \024\023\031\b\024\035\036\r\t\b \022\035\036\021\024\022 \031\ \004\026\f\021\r\031\033\021 \027\036\f\022\024\035\034\022\024 \n\036\b\ \026\027\017)Tj 0 Tw (-)Tj 0.082 Tw T* [(\n\024\r. \223\021\024 )0.5(\022\026\f\026\036\021\f\016 \027\036\007\026\r\027\017\b )0.5(\007\026\027\027\t\b, )0.5(\023\030\024\020\030\026\n\n\026 EMT, )]TJ -0.029 Tw T* (\017\027\007\031\022\006\017\016 \f\r\024\005\f\021\r \030\026\022\024\r\ \t\b \f\021\r\024\035\024\r\t\b \022\035\036\021\024\022 \017)Tj /Span<>> BDC ( )Tj EMC (\026\027\020\017\024)Tj 0 Tw (-)Tj 0.019 Tw T* (\020\036\027\036 \r\t\007\036\035\016\033\021\f\016 \022\026\022 \022\035\ \033\004\036\r\t\036 \f\024\002\t\021\017\016 \r)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\n \023\030\024)Tj 0 Tw (-)Tj T* (\006\036\f\f\036 [48].)Tj 0.089 Tw T* (\200 \027\026\f\021\024\016\013\036\036 \r\030\036\n\016 \007\r\026 \b\017\ \n\017\024\021\036\030\026\023\036\r\021\017\004\036\f\022\017\b \026\020\ \036\027)Tj 0 Tw (-)Tj 0.036 Tw T* (\021\026, \024\007\024\002\030\036\027\027\t\b \r)Tj /Span<>> BDC ( )Tj EMC (\022\026\004\036\f\021\r\036 \023\026\035\035\017\026\021\017\r\027\t\b \ \023\030\036\023\026\030\026\021\024\r )Tj 0.028 Tw T* (\023\036\030\r\024\005 \017)Tj /Span<>> BDC ( )Tj EMC (\r\021\024\030\024\005 \035\017\027\017\017 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\025\217\217)Tj /Span<>> BDC ( )Tj EMC (\227 \220\021\024 \024\022\f\026\035\017\023\035\026\021\017\027 )Tj 0.206 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\017\030\017\027\024\021\036\022\026\027 [49\22651]. \222\r\036\f\021\027\ \024, \004\021\024 \215\230\206\030\215 \n\024\032\036\021 )Tj 0.502 Tw T* [(\024\023\024\f\030\036\007\024\r\026\021\034 )0.6(\b\017\n\017\024\030\036\017\f\021\036\027\021\027\024\f\021\034 )0.6(\r)]TJ /Span<>> BDC ( )Tj EMC 17.244 0 Td (\024\023\031\b\024\035\036\r\t\b )Tj 0.328 Tw -17.244 -1.218 Td [(\022\035\036\021\024\004\027\t\b \035\017\027\017\016\b, )0.5(\023\024\035\031\004\036\027\027\t\b \017)]TJ /Span<>> BDC ( )Tj EMC (\023\030\036\007\f\021\026\021\036\035\034\027\024\005 )Tj 0.14 Tw T* (\032\036\035\036\t \017)Tj /Span<>> BDC ( )Tj EMC (\024\f\021\036\024\f\026\030\022\024\n\t [52,33]. \200)Tj /Span<>> BDC ( )Tj EMC (\027\036\007\026\r\027\036\n \017\f\f\035\036)Tj 0 Tw (-)Tj 0.291 Tw T* (\007\024\r\026\027\017\017 \002\t\035\024 \017\031\004\036\027\024 \031\ \004\026\f\021\017\036 \215\230\206\030\215 \r)Tj /Span<>> BDC ( )Tj EMC (\030\026\r\017\021\017\017 )Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0 Tw 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\214)10(\211\036\033 \035\030\032\t\033)30(\b)42(\032)-21(\240\033\233)]TJ 57.136 0 Td (REVIEW)Tj -57.136 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 23, \023\0221)69(, 202)69(4)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 23, \023\0221)69(, 202)69(4)]TJ /T1_3 1 Tf 25 0 0 25 20.79 56.0378 Tm (166)Tj ET endstream endobj 61 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 62 0 obj <>/ExtGState<>/Font<>/ProcSet[/PDF/Text]/Properties<>/Shading<>/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 63 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 64 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 65 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 463 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\037)31(\025\007\025\002\016\n)-10(\026)11(\013\007\216\001\020\203 \002\013\n, \013\006\006\025\227\220\220\002\025\ \r\013\001\001\020\203 \006\022\221\013\002\013\026\202)10(\025\002\024\025\001-)]TJ 0 -1 TD [(\002\025\201\006)-10(\026\r\016\001\001\020\024 \221\002\025\026)11(\016\220\001\025\024 \(\025\f\222\025\002 \007\220\026)11(\016\002\013\026)-19.9(\215\002\020\))]TJ 42.257 1 Td [(Color)31(ectal cancer associated with par)21(ath)31(yr)20(oid )]TJ 4.983 -1 Td [(h)11(ormone)-52(-r)31.1(elated pr)20(otein \(r)31(e)11(vie)11(w\))]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0.276 Tw 10 0 0 10 42.5197 724.8299 Tm (\220\021\024\021 \023\030\024\021\036\017\027 \007\036\005\f\021\r\031\036\ \021 \004\036\030\036 \026\031\021\024\022\030\017\027\027\t\005/\017\027\ \021\030\026)Tj 0 Tw (-)Tj 0.023 Tw 0 -1.218 TD (\022\030\017\027\027\t\005 \n\036\b\026\027\017\n\t \007\036\005\f\021\r\ \017\016. \217\026\035\017\004\027\t\036 \022\035\036\021\024\004\027\t\ \036 )Tj 0.038 Tw T* (\n\024\007\036\035\017 \017\020\030\026\033\021 \r\026\032\027\031\033 \030\ \024\035\034 \r)Tj /Span<>> BDC ( )Tj EMC (\023\024\027\017\n\026\027\017\017 \022\035\036\021\024\004\027\t\b )Tj 0.185 Tw T* (\f\024\002\t\021\017\005, \f\r\016\026\027\027\t\b \f)Tj /Span<>> BDC ( )Tj EMC (\023\026\021\024\235\017\017\024\035\024\020\017\004\036\f\022\017\n\017\ \031\f\035\024)Tj 0 Tw (-)Tj 0.194 Tw T* (\r\017\016\n\017 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\025\217\217 \004\036\035\024\r\036\022\026, \023\024\f\022\024\035\034\022\ \031 \220\021\024 \020\036\021\036\030\024\020\036\027)Tj 0 Tw (-)Tj 0.186 Tw T* (\027\024\036 \026\002\024\035\036\r\026\027\017\036 \f)Tj /Span<>> BDC ( )Tj EMC (\021\030\036\n\016 \030\026\035\017\004\027\t\n\017, \027\024 \004\026\f\ \021\017\004\027\024 )Tj 0.73 Tw 0 -1.218 TD (\023\036\030\036\022\030\t\r\026\033\013\017\n\017\f\016 \n\024\035\036\022\ \031\035\016\030\027\t\n\017 \235\036\027\024\021\017\023\026\n\017, )Tj 0.547 Tw 0 -1.218 TD [(\024\021\030\026\032\026\033\013\017\n\017 )0.6(\030\026\035\017\004\027\t\036 )0.5(\235\024\030\n\t )0.6(\027\036\f\021\026\002\017\035\034\027\024\f\021\017 )]TJ 0.009 Tw T* (\212\203\025 [35]. \222\f\f\035\036\007\024\r\026\027\017\016 )Tj /T1_2 1 Tf (in vitro)Tj /T1_1 1 Tf ( \023\024\022\026\026\035\017, \004\021\024 \023\030\024\035\017)Tj 0 Tw (-)Tj 0.065 Tw T* [(\235\036\030\026\006\017\016 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC [(\n\017\020\030\026\006\017\016 )0.5(\022\035\036\021\024\022 \035\017\027\017\017 )0.5(L)35(oV)29(o, \023\024\035\031\004\036\027\027\t\b )]TJ 0.278 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\025\217\217, \031\r\036\035\017\004\017\r\026\035\017\f\034, \022\024\020\ \007\026 \220\021\017 \022\035\036\021\022\017 \f\r\036\030\b\220\022)Tj 0 Tw (-)Tj 0.059 Tw T* (\f\023\030\036\f\f\017\030\024\r\026\035\017 \215\230\206\030\215 [36]. \ \210)Tj /Span<>> BDC ( )Tj EMC (\023\024\035\024\032\017\021\036\035\034\027\024\005 \022\024\030\030\036\ )Tj 0 Tw (-)Tj 0.049 Tw 0 -1.218 TD [(\035\016\006\017\017 )0.6(\r)]TJ /Span<>> BDC ( )Tj EMC [(\022\035\036\021\022\026\b )0.6(\035\017\027\017\017 )0.5(\030\026\022\026 )0.5(\021\024\035\f\021\024\005 )0.6(\022\017\001\022\017 )0.5(\004\036\035\024\r\036\022\026 )]TJ 0.145 Tw 0 -1.218 TD [(L)35(oV)29(o \n\036\032\007\031 \220\022\f\023\030\036\f\f\017\036\005 \215\230\206\ \030\215 \017)]TJ /Span<>> BDC ( )Tj EMC (\026\022\021\017\r\027\024\f\021\034\033 \r\027\031)Tj 0 Tw (-)Tj 0.094 Tw 0 -1.218 TD [(\021\030\017\022\035\036\021\024\004\027\024\020\024 \002\036\035\022\026\ R)-10(a)-17(c1 \017)]TJ /Span<>> BDC ( )Tj EMC (\f\031\023\036\030\f\036\n\036\005\f\021\r\026 \206\230\205\026, )Tj 0.115 Tw T* (\022\024\021\024\030\t\036 \017\020\030\026\033\021 \022\030\017\021\017\ \004\036\f\022\017\036 \030\024\035\017 \r)Tj /Span<>> BDC ( )Tj EMC (\030\036\020\031\035\016\006\017\017 \030\026)Tj 0 Tw (-)Tj 0.186 Tw T* (\035\017\004\027\t\b \022\035\036\021\024\004\027\t\b \023\030\024\006\036\ \f\f\024\r, \r\022\035\033\004\026\016 \030\036\024\030\020\026\027\017\ \026)Tj 0 Tw (-)Tj 0.294 Tw T* (\006\017\033 \026\022\021\017\027\024\r\024\020\024 \006\017\021\024\f\022\ \036\035\036\021\026, \030\026\r\017\021\017\036 \022\035\036\021\024\004\ \027\024\020\024 )Tj 0.057 Tw T* (\006\017\022\035\026, \022\035\036\021\024\004\027\031\033 \n\017\020\030\ \026\006\017\033 \017)Tj /Span<>> BDC ( )Tj EMC (\r\t\032\017\r\026\027\017\036 \022\035\036\021\024\022 \f\024)Tj 0 Tw (-)Tj 0.131 Tw T* [(\024\002\013\017\035\017 )0.5(Mul)-15.9(a)]TJ /Span<>> BDC ( )Tj EMC 5.844 0 Td [(R.V. )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 2.864 0 Td [(\f\024\026\r\021. )0.5([37]. )0.5(\203\024\022\007\026\031\027 )0.6(\017\027\021\036\020\030\017\027\026 )]TJ 0.239 Tw -8.708 -1.218 Td (\2636\2564, \022\024\021\024\030\t\005 \026\022\021\017\r\017\030\031\036\ \021\f\016 \215\230\206\030\215, \f\r\024\007\017\021 \027\026)Tj /Span<>> BDC ( )Tj EMC (\027\036\021 )Tj 0.34 Tw T* [(\024\023\024\f\030\036\007\024\r\026\027\027\024\036 \215\230\206\030\215\ \031\f\017\035\036\027\017\036 \026\022\021\017\r\026\006\017\017 R)-10(a)-17(c1. )]TJ 0.353 Tw T* (\222\027\021\036\020\030\017\027 \2636\2564 \007\026\036\021 \f\017\027\036\ \030\020\017\004\036\f\022\017\005 \f\017\020\027\026\035 \f)Tj /Span<>> BDC ( )Tj EMC (\030\036)Tj 0 Tw (-)Tj 0.165 Tw T* [(\006\036\023\021\024\030\026\n\017 )0.5(\235\026\022\021\024\030\026 )0.6(\030\024\f\021\026, )0.5(\004\021\024\002\t )0.5(\026\022\021\017\r\017\030\024\r\026\021\034 )0.6(\023\031\021\034 )]TJ 0.253 Tw T* [(\235\024\f\235\026\021\017\007\017\035\017\027\024\017\021\024\035-3-\022\ \017\027\026\t )0.7(\(PI3-K\). )0.6(\200)]TJ /Span<>> BDC ( )Tj EMC 18.44 0 Td (\f\024\r\024\022\031\023)Tj 0 Tw (-)Tj 0.019 Tw -18.44 -1.218 Td [(\027\024\f\021\017 \220\021\017 )0.5(\027\026\002\035\033\007\036\027\017\016 )0.5(\f\r\017\007\036\021\036\035\034\f\021\r\031\033\021 )0.5(\024)]TJ /Span<>> BDC ( )Tj EMC (\f\r\016\017 \n\036\032)Tj 0 Tw (-)Tj 0.108 Tw T* (\007\031 \026\022\021\017\r\027\024\f\021\034\033 \215\230\206\030\215 \017\ )Tj /Span<>> BDC ( )Tj EMC [(R)-10(a)-17(c1 \004\036\030\036 \017\027\021\036\020\030\017\027 )0.5(\2636\2564, )]TJ -0.031 Tw T* [(\004\021\024 )0.5(\023\030\017\r\024\007\017\021 )0.6(\022)]TJ /Span<>> BDC ( )Tj EMC [(\031\f\017\035\036\027\017\033 )0.6(\n\017\020\030\026\006\017\017 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 15.44 0 Td [(\017\027\r\026\017\017 )0.6(\022\035\036\021\024\022.)]TJ 0.152 Tw -15.44 -1.218 Td (\222\f\f\035\036\007\024\r\026\027\017\036 \r\026\017\n\024\f\r\016\017\ \215\230\206\030\215 \017)Tj /Span<>> BDC ( )Tj EMC (\025\217\217 \002\t\035\024 \023\030\024)Tj 0 Tw (-)Tj T* (\007\024\035\032\036\027\024 )Tj /T1_2 1 Tf 0.037 Tw 3.876 0 Td (in vitro)Tj /T1_1 1 Tf ( \f)Tj /Span<>> BDC ( )Tj EMC [(\017\f\023\024\035\034\024\r\026\027\017\036\n \007\030\031\020\017\b )0.5(\022\035\036\021\024\004\027\t\b )]TJ 0.16 Tw -3.876 -1.218 Td (\035\017\027\017\005: \221\026\f\024-2 \017)Tj /Span<>> BDC ( )Tj EMC [(HCT116. \025\035\036\021\022\017 Ca)-17(co-2 \023\030\024\017\f\b\024\007\016\021 )]TJ 0.045 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC [(\026\007\036\027\024\022\026\030\006\017\027\024\n\t \021\024\035\f\021\024\ \005 )0.5(\022\017\001\022\017 \004\036\035\024\r\036\022\026 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC (\f\023\024\027)Tj 0 Tw (-)Tj 0.11 Tw T* (\021\026\027\027\024 \007\017\235\235\036\030\036\027\006\017\030\031\033\ \021\f\016 )Tj /T1_2 1 Tf (in vitro)Tj /T1_1 1 Tf ( \r)Tj /Span<>> BDC ( )Tj EMC (\f\021\026\027\007\026\030\021\027\t\b \031\f)Tj 0 Tw (-)Tj 0.261 Tw T* (\035\024\r\017\016\b \022\031\035\034\021\017\r\017\030\024\r\026\027\017\ \016, \021\026\022\017\n \024\002\030\026\024\n, \023\030\024\016\r\035\ \016\016 )Tj 0.364 Tw T* (\220\027\021\036\030\024\006\017\021\024\023\024\007\024\002\027\t\036 \f\ \021\030\031\022\021\031\030\027\t\036 \017)Tj /Span<>> BDC ( )Tj EMC (\235\031\027\022\006\017\024\027\026\035\034)Tj 0 Tw (-)Tj 0.333 Tw T* (\027\t\036 \b\026\030\026\022\021\036\030\017\f\021\017\022\017. \025\035\ \036\021\024\004\027\026\016 \035\017\027\017\016 \022\026\030\006\017\027\ \024\n\t )Tj 0.156 Tw T* (\021\024\035\f\021\024\005 \022\017\001\022\017 \004\036\035\024\r\036\022\ \026 HCT116 \007\036\n\024\027\f\021\030\017\030\031\036\021 \002\024)Tj 0 Tw (-)Tj 0.073 Tw T* (\035\036\036 \026\020\030\036\f\f\017\r\027\t\005 \235\036\027\024\021\017\ \023 \017-\026 \020\017\023\036\030\026\022\021\017\r\017\030\031\033\013\ \017\b )Tj 0.123 Tw T* [(\n\031\021\026\006\017\005 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC (\020\036\027\026\b )Tj /T1_2 1 Tf 0 Tw 7.199 0 Td [(KRA)50(S)]TJ /T1_1 1 Tf 0.123 Tw ( \017)Tj /Span<>> BDC ( )Tj EMC 3.204 0 Td [(PIK3C)20(A )0.5([35,38]. \217\026\027\036\036 )0.5(\002\t\035\024 )]TJ 0.142 Tw -10.403 -1.218 Td [(\023\024\022\026\026\027\024, \004\021\024 )0.5(\022\026\022 \r)]TJ /Span<>> BDC ( )Tj EMC [(\022\035\036\021\022\026\b )0.5(Ca)-17(co-2, \021\026\022 \017)]TJ /Span<>> BDC ( )Tj EMC (\r \022\035\036\021\022\026\b )Tj 0.302 Tw T* (HCT116 \220\022\f\023\030\036\f\f\017\030\031\036\021\f\016 PTH1R, \017)Tj /Span<>> BDC ( )Tj EMC (\004\021\024 \220\022\024\020\036\027\027\t\005 )Tj 0.57 Tw T* (\215\230\206\030\215 \n\024\007\031\035\017\030\031\036\021 \023\030\024\ \020\030\036\f\f\017\030\024\r\026\027\017\036 \022\035\036\021\024\004\027\ \024\020\024 )Tj 0.369 Tw T* (\006\017\022\035\026 \017)Tj /Span<>> BDC ( )Tj EMC (\024\022\026\t\r\026\036\021 \023\030\024\035\017\235\036\030\026\021\017\ \r\027\024\036 \017)Tj /Span<>> BDC ( )Tj EMC (\026\013\017\021\027\024\036 )Tj 0.015 Tw T* (\007\036\005\f\021\r\017\036 \023\024\f\030\036\007\f\021\r\024\n \f\017\ \020\027\026\035\034\027\t\b \023\031\021\036\005 MAPK \017)Tj /Span<>> BDC ( )Tj EMC (PI3-)Tj -0.044 Tw T* [(\022\017\027\026\t/Ak)-23.9(t [39,40]. \210\002\027\026\030\031\032\036\027\024, \004\021\024 \r\r\036\ \007\036\027\017\036 \215\230\206\030\215 )]TJ 0.005 Tw T* [(\031\r\036\035\017\004\017\r\026\036\021 \022\024\035\017\004\036\f\021\r\ \024 \032\017\r\t\b \022\035\036\021\024\022 Ca)-17(co-2. \215\230\206\030\215 )]TJ 0.117 Tw T* (\017\027\007\031\006\017\030\031\036\021 \235\024\f\235\024\030\017\035\017\ \030\024\r\026\027\017\036 \017)Tj /Span<>> BDC ( )Tj EMC (\016\007\036\030\027\031\033 \021\030\026\027\f\035\024)Tj 0 Tw (-)Tj 0.09 Tw T* [(\022\026\006\017\033 ERK )0.5(1/2, \263 p38 MAPK \017)]TJ /Span<>> BDC ( )Tj EMC [(Ak)-23.9(t, \027\036 \r\035\017\016\016 )0.5(\027\026)]TJ /Span<>> BDC ( )Tj EMC (\235\024\f)Tj 0 Tw (-)Tj -0.024 Tw T* (\235\024\030\017\035\017\030\024\r\026\027\017\036 JNK. \025\030\024\n\036\ \021\024\020\024, \026\r\017\f\017\n\024\036 \024\021 \215\230\206\030\ \215 )Tj 0.177 Tw T* [(\235\024\f\235\024\030\017\035\017\030\024\r\026\027\017\036 )0.5(ERK \r\024\f\f\021\026\027\026\r\035\017\r\026\036\021\f\016 \023\030\017\ )]TJ /Span<>> BDC ( )Tj EMC (\017\027)Tj 0 Tw (-)Tj 0.023 Tw T* (\020\017\002\017\030\024\r\026\027\017\017 \026\022\021\017\r\027\024\f\021\ \017 PI3K. \215\024\f\035\036 \016\007\036\030\027\024\005 \021\030\026\027\ \f)Tj 0 Tw (-)Tj 0.132 Tw T* [(\035\024\022\026\006\017\017 MAPK \235\026\022\021\024\030\t \021\030\026\ \027\f\022\030\017\023\006\017\017 A)15(TF-1 \017)]TJ /Span<>> BDC ( )Tj EMC (CREB )Tj 0.286 Tw T* (\026\022\021\017\r\017\030\024\r\026\035\017\f\034 \007\r\031\b\235\026\ \027\t\n \024\002\030\026\024\n. \025\030\024\n\036 \021\024\020\024, )Tj 0.072 Tw T* (\215\230\206\030\215 \017\027\007\031\006\017\030\031\036\021 \021\030\026\ \027\f\035\024\022\026\006\017\033 \r)Tj /Span<>> BDC ( )Tj EMC (\016\007\030\024 \256-\022\026\021\036\027\017\027\026, )Tj 0.016 Tw 23.244 64.543 Td (\002\036\035\022\026, \017\020\030\026\033\013\036\020\024 \022\035\033\004\ \036\r\031\033 \030\024\035\034 \r)Tj /Span<>> BDC ( )Tj EMC (\023\024\007\007\036\030\032\026\027\017\017 \030\024)Tj 0 Tw (-)Tj 0.075 Tw T* (\f\021\026 \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\035\017\235\036\030\026\006\017\017 \022\024\035\024\030\036\ \022\021\026\035\034\027\024\020\024 \030\026\022\026, \017)Tj /Span<>> BDC ( )Tj EMC (\031\r\036\035\017)Tj 0 Tw (-)Tj 0.075 Tw T* (\004\017\r\026\036\021 \022\024\035\017\004\036\f\021\r\024 \022\026\022\ \023\024\017\021\017\r\027\t\b \030\036\020\031\035\016\021\024\030\024\ \r \022\035\036)Tj 0 Tw (-)Tj 0.045 Tw T* [(\021\024\004\027\024\020\024 \006\017\022\035\026 c-M)16(yc, \021\026\022 \017)]TJ /Span<>> BDC ( )Tj EMC (\006\017\022\035\017\027\026 D. \222\f\f\035\036\007\024\r\026\027\017\016\ )Tj -0.01 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (ERK1/ 2, \263 p38 MAPK \017)Tj /Span<>> BDC ( )Tj EMC (PI3K \023\024\022\026\026\035\017, \004\021\024 \215\230\206\030\215 \030\ \036)Tj 0 Tw (-)Tj 0.134 Tw T* [(\020\031\035\017\030\031\036\021 \023\030\024\035\017\235\036\030\026\006\ \017\033 \022\035\036\021\024\022 Ca)-17(co-2 \023\024\f\030\036\007\f\021\r\024\n )]TJ 0 Tw 0 -1.218 TD (\220\021\017\b \f\017\020\027\026\035\034\027\t\b \023\031\021\036\005.)Tj -0.034 Tw 0 -1.218 TD (\224\021\017 \007\026\027\027\t\036 \030\026\f\001\017\030\016\033\021 \f\ \031\013\036\f\021\r\031\033\013\017\036 \023\030\036\007\f\021\026\r\035\ \036\027\017\016 )Tj 0.072 Tw T* (\024)Tj /Span<>> BDC ( )Tj EMC (\030\024\035\017 \220\022\024\020\036\027\027\024\020\024 \215\230\206\030\ \215 \r)Tj /Span<>> BDC ( )Tj EMC [(\024\023\031\b\024\035\036\r\t\b )0.5(\022\035\036\021\022\026\b \022\017)]TJ 0 Tw (-)Tj 0.048 Tw T* (\001\036\004\027\017\022\026 \017)Tj /Span<>> BDC ( )Tj EMC (\023\024\r\024\035\016\033\021 \r\t\016\r\017\021\034 \f\017\020\027\026\ \035\034\027\t\036 \023\031\021\017, \031\004\026)Tj 0 Tw (-)Tj -0.064 Tw T* (\f\021\r\031\033\013\017\036 \r)Tj /Span<>> BDC ( )Tj EMC (\n\017\021\024\020\036\027\027\024\n \007\036\005\f\021\r\017\017 \220\021\ \024\020\024 \002\036\035\022\026 \027\026)Tj /Span<>> BDC ( )Tj EMC (\022\035\036\021)Tj 0 Tw (-)Tj 0.044 Tw T* (\022\017 \221\026\f\024-2 [41]. \200)Tj /Span<>> BDC ( )Tj EMC (\017\f\f\035\036\007\024\r\026\027\017\016\b, \r\t\023\024\035\027\036\027\ \027\t\b \r)Tj /Span<>> BDC ( )Tj EMC (\021\024\005 )Tj -0.027 Tw 0 -1.218 TD (\032\036 \035\026\002\024\030\026\021\024\030\017\017 [42], \r)Tj /Span<>> BDC ( )Tj EMC (\022\035\036\021\022\026\b \025\217\217 \002\t\035\026 \024\002\027\026\030\ \031\032\036\027\026 )Tj 0.136 Tw 0 -1.218 TD (\026\022\021\017\r\026\006\017\016 \023\024\007 \007\036\005\f\021\r\017\ \036\n \215\230\206\030\215 \027\036\030\036\006\036\023\021\024\030\027\ \024\005 \021\017)Tj 0 Tw (-)Tj 0.069 Tw 0 -1.218 TD [(\030\024\017\027\022\017\027\026\t Sr)-32(c, \023\030\024\021\036\017\027\022\017\027\026\t C, \235\024\f\235\024\ \017\027\024\017\021\017\007-)]TJ 0.099 Tw T* [(3-\022\017\027\026\t )0.5(\(PI3K\), )0.5(\023\030\024\021\036\017\027\022\017\027\026\t )0.5(B )0.5(\017\035\017 )0.5(Ak)-24(t)]TJ /Span<>> BDC ( )Tj EMC 18.474 0 Td [(\227 )0.5(\022\017\027\026)]TJ 0 Tw (-)Tj 0.096 Tw -18.474 -1.218 Td (\t, \030\036\020\031\035\017\030\031\036\n\024\005 \r\027\036\022\035\036\ \021\024\004\027\t\n \f\017\020\027\026\035\024\n \(ERK\) 1/2 )Tj 0.061 Tw T* (\017, \021\026\022\017\n \024\002\030\026\024\n, \023\024\035\031\004\036\ \027\t \007\024\022\026\026\021\036\035\034\f\021\r\026 \021\024\020\024\ , \004\021\024 )Tj 0.063 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\024\002\036\017\b \022\035\036\021\024\004\027\t\b \035\017\027\017\016\ \b \215\230\206\030\215 \017\027\007\031\006\017\030\031\036\021 \n\017\020\ \030\026)Tj 0 Tw (-)Tj -0.003 Tw T* (\006\017\033 \022\035\036\021\024\022 \004\036\030\036 \f\017\020\027\026\ \035\034\027\t\005 \023\031\021\034 RSK/ERK1/2, \027\024 \027\036 )Tj 0.131 Tw T* [(\004\036\030\036 p38 MAPK. Mar)-22(t\355n)]TJ /Span<>> BDC ( )Tj EMC (M.J. \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. [43] \017\f\f\035\036\007\024)Tj 0 Tw (-)Tj 0.306 Tw T* [(\r\026\035\017 \023\024\021\036\027\006\017\026\035\034\027\t\036 )0.5(\021\036\030\026\023\036\r\021\017\004\036\f\022\017\036 \n\017\001\036\027\ \017 \007\035\016 )]TJ 0.15 Tw T* (\024\f\021\026\027\024\r\022\017 \030\024\f\021\026 \022\035\036\021\024\ \022 \022\024\035\024\030\036\022\021\026\035\034\027\024\020\024 \030\026\ \022\026, \023\024\007)Tj 0 Tw (-)Tj 0.171 Tw T* (\r\036\030\020\001\017\b\f\016 \r\024\007\036\005\f\021\r\017\033 \215\230\ \206\030\215. \037\036\035\034\033 \220\021\024\005 \030\026\002\024\021\ \t )Tj 0.232 Tw T* (\002\t\035\024 \017\f\f\035\036\007\024\r\026\027\017\036 \r\035\017\016\ \027\017\016 \215\230\206\030\215 \027\026)Tj /Span<>> BDC ( )Tj EMC (\n\017\021\024\020\036\027\027\t\036 )Tj 0.042 Tw T* (\022\026\f\022\026\007\t, \026\022\021\017\r\017\030\031\036\n\t\036 \r)Tj /Span<>> BDC ( )Tj EMC 10.761 0 Td [(\024\021\r\036\021 )0.5(\027\026)]TJ /Span<>> BDC ( )Tj EMC [(\r\024\007\036\005\f\021\r\017\036 )0.5(\220\021\024\020\024 )]TJ 0.137 Tw -10.761 -1.218 Td (\002\036\035\022\026, \r)Tj /Span<>> BDC ( )Tj EMC (\007\r\031\b \022\035\036\021\024\004\027\t\b \035\017\027\017\016\b \025\ \217\217 \f)Tj /Span<>> BDC ( )Tj EMC (\235\036\027\024\021\017\023\017\004\036)Tj 0 Tw (-)Tj 0.089 Tw T* [(\f\022\017\n\017 \030\026\035\017\004\017\016\n\017 )0.5(\(\022\035\036\021\022\017 Ca)-17(co-2 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC [(\022\035\036\021\022\017 )0.5(HCT116\), )]TJ 0.142 Tw T* (\026)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\032\036 \017\031\004\036\027\017\036 \n\024\035\036\022\031\ \035\016\030\027\t\b \n\036\b\026\027\017\n\024\r \r)Tj /Span<>> BDC ( )Tj EMC (\220\021\017\b )Tj 0.29 Tw T* (\007\r\031\b \021\017\023\026\b \024\023\031\b\024\035\036\r\t\b \022\035\ \036\021\024\022. \202\r\021\024\030\t \023\030\024\007\036\n\024\027)Tj 0 Tw (-)Tj 0.143 Tw T* [(\f\021\030\017\030\024\r\026\035\017, )0.6(\004\021\024 )0.5(\007\035\017\021\036\035\034\027\024\036 )0.6(\r\r\036\007\036\027\017\036 )0.5(\215\230\206\030\215 )0.6(\022\f\036\027\024)]TJ 0 Tw (-)Tj 0.324 Tw T* (\021\030\026\027\f\023\035\026\027\021\026\021\026\n \020\024\035\t\b \n\ \t\001\036\005 \026\022\021\017\r\017\030\031\036\021 ERK 1/2 )Tj 0.138 Tw T* (MAPK \017)Tj /Span<>> BDC ( )Tj EMC (\007\030\031\020\017\036 \022\024\n\023\024\027\036\027\021\t \n\017\021\ \024\020\036\027\027\t\b \f\017\020\027\026\035\034\027\t\b )Tj 0.19 Tw T* (\023\031\021\036\005. \025\030\024\n\036 \021\024\020\024, \220\021\017 \ \030\036\031\035\034\021\026\021\t \023\024\022\026\t\r\026\033\021, \004\ \021\024 )Tj -0.002 Tw T* [(Sr)-32(c, \023\030\024\021\036\017\027\022\017\027\026\t C \017)]TJ /Span<>> BDC ( )Tj EMC [(Ak)-23.9(t \017\020\030\026\033\021 \030\024\035\034 \r)]TJ /Span<>> BDC ( )Tj EMC (\f\017\020\027\026\035\034\027\024\n )Tj 0.154 Tw T* (\n\036\b\026\027\017\n\036, \023\030\017\r\024\007\016\013\036\n \022)Tj /Span<>> BDC ( )Tj EMC (\026\022\021\017\r\026\006\017\017 ERK 1/2 MAPK )Tj -0.026 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\023\024\n\024\013\034\033 \215\230\206\030\215 \r)Tj /Span<>> BDC ( )Tj EMC (\007\r\031\b \022\035\036\021\024\004\027\t\b \035\017\027\017\016\b \025\ \217\217, \022\024\021\024)Tj 0 Tw (-)Tj T* (\030\t\036 \235\036\027\024\021\017\023\017\004\036\f\022\017 \030\026\035\ \017\004\026\033\021\f\016.)Tj 0.054 Tw T* (\200 \f\024\r\024\022\031\023\027\024\f\021\017 \220\021\017 \030\036\031\ \035\034\021\026\021\t \023\024\022\026\026\035\017, \004\021\024 \r)Tj /Span<>> BDC ( )Tj EMC (\022\035\036\021)Tj 0 Tw (-)Tj 0.054 Tw T* (\022\026\b \025\217\217 \215\230\206\030\215 \n\024\007\031\035\017\030\031\ \036\021 \023\030\024\020\030\036\f\f\017\030\024\r\026\027\017\036 \017\ )Tj /Span<>> BDC ( )Tj EMC (\023\030\024)Tj 0 Tw (-)Tj 0.188 Tw T* (\035\017\235\036\030\026\006\017\033 \022\035\036\021\024\004\027\024\020\ \024 \006\017\022\035\026 \023\024\f\030\036\007\f\021\r\024\n \n\024\007\ \031\035\016)Tj 0 Tw (-)Tj 0.222 Tw T* (\006\017\017 \027\036\f\022\024\035\034\022\017\b \n\017\021\024\020\036\ \027\027\t\b \023\031\021\036\005, \021\026\022\017\b \022\026\022 PI3K,\ )Tj 0.12 Tw T* [(Ak)-24(t, )0.5(ERK1/2 MAPK, )0.5(p38 )0.5(MAPK \017)]TJ /Span<>> BDC ( )Tj EMC 13.353 0 Td [(RSK. )0.5(\223\021\024\002\t \023\024\007\021\r\036\030)]TJ 0 Tw (-)Tj 0.083 Tw -13.353 -1.218 Td (\007\017\021\034, \004\021\024 \026\235\017\022\f\017\030\024\r\026\027\ \027\t\036 \030\036\031\035\034\021\026\021\t \002\t\035\017 \017\f\022\ \035\033)Tj 0 Tw (-)Tj 0.3 Tw T* [(\004\017\021\036\035\034\027\024 )0.6(\024\023\024\f\030\036\007\024\r\026\027\t )0.5(\215\230\206\030\215 )0.6(\(1-34\) )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 18.099 0 Td (\r\022\035\033\004\026\035\017 )Tj 0.192 Tw -18.099 -1.218 Td [(\021\024\035\034\022\024 \026\022\021\017\r\026\006\017\033 PTHR1, N)-14(ovoa D\355a)-24(z M.B. \017)]TJ /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. )Tj 0.132 Tw T* ([44] \017\f\023\024\035\034\024\r\026\035\017 \026\027\021\017\021\036\035\ \024 \023\030\024\021\017\r PTHR1 \007\035\016 \002\035\024)Tj 0 Tw (-)Tj 0.359 Tw T* (\022\017\030\024\r\026\027\017\016 \r\026\017\n\024\007\036\005\f\021\r\ \017\016 \215\230\206\030\215/PTHR1, \026)Tj /Span<>> BDC ( )Tj EMC (\026\021\036\n )Tj 0.123 Tw T* (\024\006\036\027\017\035\017 \f\024\f\021\024\016\027\017\036 \026\022\021\ \017\r\027\024\005 ERK1/2 \r)Tj /Span<>> BDC ( )Tj EMC (\220\021\017\b \031\f\035\024\r\017)Tj 0 Tw (-)Tj 0.123 Tw T* [(\016\b, )0.5(\023\024\f\022\024\035\034\022\031 )0.6(\220\021\026 )0.5(\022\017\027\026\026, )0.5(\022\024\021\024\030\026\016 )0.6(\031\004\026\f\021\r\031\036\021 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 19.837 0 Td (\002\024\035\034)Tj 0 Tw (-)Tj 0.288 Tw -19.837 -1.218 Td (\001\017\027\f\021\r\036 \023\030\024\006\036\f\f\024\r, \017\027\007\031\ \006\017\030\024\r\026\027\027\t\b \215\230\206\030\215. \207\t\035\024 \ )Tj 0.13 Tw T* (\031\f\021\026\027\024\r\035\036\027\024, \004\021\024 \026\027\021\017\021\ \036\035\024 \023\030\024\021\017\r PTHR1 \023\024\035\027\024\f\021\034\ \033 )Tj 0.33 Tw T* [(\023\024\007\026\r\035\016\035\024 \024\021\r\036\021 \022\026\022 \022\035\ \036\021\024\022 Ca)-17(co-2, \021\026\022 \017)]TJ /Span<>> BDC ( )Tj EMC (\022\035\036\021\024\022 )Tj 0.057 Tw T* (HCT116 \027\026)Tj /Span<>> BDC ( )Tj EMC (\215\230\206\030\215, \031\022\026\t\r\026\016 \027\026)Tj /Span<>> BDC ( )Tj EMC (\021\024, \004\021\024 \026\022\021\017\r\026\006\017\016 ERK )Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 0 Tw 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\214)10(\211\036\033 \035\030\032\t\033)30(\b)42(\032)-21(\240\033\233)]TJ 57.136 0 Td (REVIEW)Tj /T1_3 1 Tf 25 0 0 25 505.4521 56.0378 Tm (165)Tj ET endstream endobj 462 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.204 Tw 10 0 0 10 70.8661 724.8299 Tm (\207\t\035\024 \023\024\022\026\026\027\024, \004\021\024 \215\230\206\030\ \215 \220\022\f\023\030\036\f\f\017\030\031\036\021\f\016 \021\026\022\017\ \n\017 )Tj 0.168 Tw 0 -1.218 TD (\024\023\031\b\024\035\016\n\017 \023\017\013\036\r\026\030\017\021\036\035\ \034\027\024\005 \f\017\f\021\036\n\t, \022\026\022 \030\026\022 \023\024\ \007)Tj 0 Tw (-)Tj 0.278 Tw T* [(\032\036\035\031\007\024\004\027\024\005 )0.6(\032\036\035\036\t )0.5([15], )0.6(\032\036\035\031\007\022\026 )0.5([16], )0.5(\023\017\013\036\r\024\007\026 )]TJ 0.021 Tw T* ([17], \021\024\035\f\021\024\005 \022\017\001\022\017 [18], \026)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\032\036 \030\016\007\026 \007\030\031\020\017\b \f\017\f\021\ \036\n )Tj -0.041 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\024\030\020\026\027\024\r [19,20,21], \017)Tj /Span<>> BDC ( )Tj EMC (\004\021\024 \024\023\031\b\024\035\036\r\026\016 \f\036\022\030\036\006\ \017\016 \220\021\024\020\024 )Tj 0.075 Tw T* (\002\036\035\022\026 \024\021\r\036\021\f\021\r\036\027\027\026 \026)Tj /Span<>> BDC ( )Tj EMC (\024\002\030\026\024\r\026\027\017\036 \017)Tj /Span<>> BDC ( )Tj EMC (\030\026\f\023\030\024\f\021\030\026\027\036)Tj 0 Tw (-)Tj 0.13 Tw 0 -1.218 TD (\027\017\036 \024\023\031\b\024\035\036\005. \224\021\024 \024\023\030\036\ \007\036\035\016\036\021 \026\022\021\017\r\027\031\033 \030\026\030\026\ \002\024\021\022\031 )Tj 0.138 Tw 0 -1.218 TD [(\235\026\030\n\026\022\024\035\024\020\017\004\036\f\022\017\b )0.5(\f\031\002\f\021\026\027\006\017\005 \027\026)]TJ /Span<>> BDC ( )Tj EMC (\024\f\027\024\r\036 \026\027\026\035\024\020\024\r )Tj 0.186 Tw T* (\220\021\024\020\024 \002\036\035\022\026, \026)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\032\036 \036\020\024 \023\036\023\021\017\007\027\t\b \007\024\ \n\036\027\024\r \017)Tj /Span<>> BDC ( )Tj EMC (\017\f)Tj 0 Tw (-)Tj 0.114 Tw T* (\f\035\036\007\024\r\026\027\017\036 \r\024\n\024\032\027\024\f\021\017\ \017\b \023\030\017\n\036\027\036\027\017\016 \r)Tj /Span<>> BDC ( )Tj EMC (\022\026\004\036\f\021\r\036 )Tj 0 Tw T* (\035\036\022\026\030\f\021\r\036\027\027\t\b \f\030\036\007\f\021\r.)Tj /T1_1 1 Tf 0.031 Tw 0 -2.436 TD (\026\213\004\t\214\002\217\235\213\001 \212\004\006\004\003\n\002\006\214\ \002\b-\006\002\240\217\003\r\b\b\002\n\002 \212\006\002\003\r\t\b\004 \ )Tj 0.023 Tw 0 -1.218 TD (\t)Tj /Span<>> BDC ( )Tj EMC (\220\002\f\002\006\r\220\003\004\f\001\b\002\n\002 \002\b\220\002\n\r\b\r\ \213\004)Tj /T1_0 1 Tf 0.175 Tw 0 -1.218 TD (\200)Tj /Span<>> BDC ( )Tj EMC (1987 \020\024\007\031 \021\030\036\n\016 \027\036\026\r\017\f\017\n\t\n\ \017 \020\030\031\023\023\026\n\017 \031\004\036\027\t\b )Tj 0.177 Tw T* ([22,23,24] \002\t\035\017 \024\023\031\002\035\017\022\024\r\026\027\t \030\ \036\031\035\034\021\026\021\t \017\f\f\035\036\007\024)Tj 0 Tw (-)Tj 0.104 Tw T* [(\r\026\027\017\005, )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC [(\022\024\021\024\030\t\b )0.5(\002\t\035 )0.5(\024\002\027\026\030\031\032\036\027 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC [(\r\t\007\036\035\036\027 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 20.366 0 Td (\030\026)Tj 0 Tw (-)Tj 0.7 Tw -20.366 -1.218 Td [(\035\017\004\027\t\b )0.6(\035\024\022\026\004\036\f\021\r\036\027\027\t\b )0.5(\024\023\031\b\024\035\036\005 )0.6(\027\036\017\r\036\f\021\027\t\005 )]TJ 0.14 Tw T* (\030\026\027\036\036 \002\036\035\024\022, \022\024\021\024\030\t\005 \024\ \002\035\026\007\026\035 \r\t\f\024\022\024\005 N-\022\024\027\006\036\r\ \024\005 )Tj 0.084 Tw T* (\020\024\n\024\035\024\020\017\036\005 \f)Tj /Span<>> BDC ( )Tj EMC (\023\026\030\026\021\017\030\036\024\017\007\027\t\n \020\024\030\n\024\027\ \024\n \017)Tj /Span<>> BDC ( )Tj EMC (\004\026\f\021\017\004\027\024 )Tj 0.006 Tw T* (\f\b\024\007\027\024\005 \f)Tj /Span<>> BDC ( )Tj EMC (\027\017\n \002\017\024\035\024\020\017\004\036\f\022\024\005 \026\022\021\ \017\r\027\024\f\021\034\033. \221\b\024\007\f\021\r\024 )Tj -0.046 Tw T* (\220\021\024\020\024 \002\036\035\022\026 \023\024)Tj /Span<>> BDC ( )Tj EMC (\f\021\030\031\022\021\031\030\036 \017)Tj /Span<>> BDC ( )Tj EMC (\002\017\024\035\024\020\017\004\036\f\022\024\005 \026\022\021\017\r\027\ \024\f\021\017 )Tj 0.227 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\023\026\030\026\021\017\030\036\024\017\007\027\t\n \020\024\030\n\024\027\ \024\n \024\023\030\036\007\036\035\017\035\024 \036\020\024 \027\t\027\036\ )Tj 0.009 Tw T* (\f\031\013\036\f\021\r\031\033\013\036\036 \027\026\r\026\027\017\036)Tj /Span<>> BDC ( )Tj EMC (\227 \023\026\030\026\021\017\030\036\024\017\007\027\t\005 \020\024\030\ \n\024\027-)Tj 0.593 Tw T* [(\030\024\007\f\021\r\036\027\027\t\005 \002\036\035\024\022 \(P)40(ar)-32.9(a)15(t)-13(hyr)-32(oid hor)-16(mone-r)-24(el)-15.9(a)15(ted )]TJ 0 Tw T* [(p)25(r)-32(o)17(tein\).)]TJ -0.044 Tw T* [(\003\026 \023\030\024\001\036\007\001\017\036 \020\024\007\t \n\027\024\020\ \024\004\017\f\035\036\027\027\t\n\017 )0.5(\017\f\f\035\036\007\024\r\026\027\017\016)]TJ 0 Tw (-)Tj 0.028 Tw T* (\n\017 \002\t\035\024 \031\f\021\026\027\024\r\035\036\027\024 \001\017\030\ \024\022\024\036 \030\026\f\023\030\024\f\021\030\026\027\036\027\017\036\ \220\021\024)Tj 0 Tw (-)Tj 0.122 Tw T* (\020\024 \002\036\035\022\026 \r)Tj /Span<>> BDC ( )Tj EMC (\030\026\035\017\004\027\t\b \027\024\030\n\026\035\034\027\t\b \017)Tj /Span<>> BDC ( )Tj EMC (\024\027\022\024\021\030\026\027\f\235\024\030)Tj 0 Tw (-)Tj 0.145 Tw T* (\n\017\030\024\r\026\027\027\t\b \021\022\026\027\016\b, \024\023\017\f\026\ \027\t \n\027\024\020\024\004\017\f\035\036\027\027\t\036 \r\017\007\t )Tj 0.18 Tw T* (\036\020\024 \002\017\024\035\024\020\017\004\036\f\022\024\005 \026\022\ \021\017\r\027\024\f\021\017, \220\027\007\024\022\030\017\027\027\t\005\ , \023\026\030\026)Tj 0 Tw (-)Tj 0.204 Tw T* [(\022\030\017\027\027\t\005, \026\031\021\024\022\030\017\027\027\t\005 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC (\017\027\021\030\026\022\030\017\027\027\t\005 \n\036\b\026\027\017\n\t\ )Tj 0.216 Tw T* (\007\036\005\f\021\r\017\016 \r)Tj /Span<>> BDC ( )Tj EMC (\235\017\017\024\035\024\020\017\004\036\f\022\017\b \017)Tj /Span<>> BDC ( )Tj EMC (\023\026\021\024\035\024\020\017\004\036\f\022\017\b \030\036)Tj 0 Tw (-)Tj 0.184 Tw T* (\026\022\006\017\016\b, \007\024\022\026\026\027\026 \036\020\024 \r\036\ \007\031\013\026\016 \030\024\035\034 \r)Tj /Span<>> BDC ( )Tj EMC (\024\030\020\026\027\024\020\036\027\036\036 )Tj 0.335 Tw T* ([25\22628]. \215\024\f\022\024\035\034\022\031 \215\230\206\030\215 \001\ \017\030\024\022\024 \030\026\f\023\030\024\f\021\030\026\027\036\027 )Tj 0.203 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\027\024\030\n\026\035\034\027\t\b \021\022\026\027\016\b, \036\020\024 \ \f\036\022\030\036\006\017\016 \024\023\031\b\024\035\016\n\017, \r\036)Tj 0 Tw (-)Tj 0.05 Tw T* [(\030\024\016\021\027\024, \023\030\036\007\f\021\026\r\035\016\036\021 )0.5(\f\024\002\024\005 \220\031\021\024\023\017\004\036\f\022\031\033 \020\017\ \023\036\030\023\030\024)]TJ 0 Tw (-)Tj 0.126 Tw T* (\007\031\022\006\017\033, \026)Tj /Span<>> BDC ( )Tj EMC (\027\036 \220\022\021\024\023\017\004\036\f\022\031\033 \023\030\024\007\ \031\022\006\017\033 \220\021\024\020\024 \002\036\035\022\026. )Tj 0.16 Tw T* (\224\r\024\035\033\006\017\024\027\027\024\036 \030\024\007\f\021\r\024 \ \023\024\r\024\035\016\036\021 \023\026\030\026\021\017\030\036\024\017\ \007\027\024\n\031 )Tj 0.119 Tw T* [(\020\024\030\n\024\027\031 )0.5(\(\215\230\206\) )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC 7.208 0 Td [(\215\230\206\030\215 )0.5(\f\r\016\t\r\026\021\034\f\016 )0.6(\f)]TJ /Span<>> BDC ( )Tj EMC 9.183 0 Td [(\024\007\027\017\n )0.5(\024\002\013\017\n )]TJ 0.307 Tw -16.392 -1.218 Td [(\030\036\006\036\023\021\024\030\024\n \(PTH1R\), )0.5(\026\022\021\017\r\026\006\017\016 \022\024\021\024\030\024\020\024 \026\ \023\031\f\022\026)]TJ 0 Tw (-)Tj 0.115 Tw T* (\036\021 \030\036\026\035\017\026\006\017\033 \023\035\036\005\024\021\030\ \024\023\027\t\b \235\031\027\022\006\017\005 \215\230\206 \017)Tj /Span<>> BDC ( )Tj EMC (\215\230\206\030\215 )Tj 0.353 Tw T* ([29]. \200\023\024\f\035\036\007\f\021\r\017\017 \002\t\035\024 \031\f\021\ \026\027\024\r\035\036\027\024, \004\021\024 \215\230\206\030\215 )Tj 0.084 Tw T* [(\023\030\024\007\031\006\017\030\031\036\021\f\016 )0.6(\024\023\031\b\024\035\036\r\t\n\017 )0.5(\022\035\036\021\022\026\n\017 )0.6(\n\027\024\020\024\004\017\f\035\036\027)]TJ 0 Tw (-)Tj 0.162 Tw T* (\027\t\b \r\017\007\024\r \030\026\022\026, \f\023\024\f\024\002\f\021\r\ \031\016 \023\030\024\035\017\235\036\030\026\006\017\017, \r\t\032\017)Tj 0 Tw (-)Tj 0.215 Tw T* (\r\026\036\n\024\f\021\017, \017\027\r\026\017\017 \024\023\031\b\024\035\ \036\r\t\b \022\035\036\021\024\022 \017)Tj /Span<>> BDC ( )Tj EMC (\024\023\024\f\030\036\007\031\016 )Tj 0.103 Tw T* (\020\017\023\036\030\022\026\035\034\006\017\036\n\017\033. \222\002\t\021\ \024\004\027\026\016 \023\030\024\007\031\022\006\017\016 \024\023\031\b\ \024\035\034\033 )Tj 0.302 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC 1.052 0 Td [(\r\t\f\r\024\002\024\032\007\036\027\017\036 )0.6(\r)]TJ /Span<>> BDC ( )Tj EMC 8.166 0 Td [(\006\017\030\022\031\035\017\030\031\033\013\031\033 )0.6(\022\030\024\r\034 )0.6(\215\230\206\030\215 )]TJ 0.162 Tw -9.218 -1.218 Td (\f\021\017\n\031\035\017\030\031\036\021 \030\036\024\030\002\006\017\033\ \022\024\f\021\027\024\005 \021\022\026\027\017 \017)Tj /Span<>> BDC ( )Tj EMC (\030\036\026\002\f\024\030\002)Tj 0 Tw (-)Tj 0.042 Tw T* (\006\017\033 \023\024\004\036\004\027\024\020\024 \022\026\035\034\006\017\ \016 \017, \021\026\022\017\n \024\002\030\026\024\n, \030\024\035\034 \ \220\021\024\020\024 )Tj -0.01 Tw T* (\023\030\024\021\036\017\027\026 \r)Tj /Span<>> BDC ( )Tj EMC (\030\026\r\017\021\017\017 \035\024\022\026\004\036\f\021\r\036\027\027\ \024\005 \020\017\023\036\030\022\026\035\034\006\017\036)Tj 0 Tw (-)Tj T* (\n\017\017 \002\t\035\026 \r\t\016\f\027\036\027\026.)Tj 0.446 Tw T* [(\200\026\017\n\024\f\r\016\034 )0.5(\215\230\206\030\215 \017)]TJ /Span<>> BDC ( )Tj EMC (\022\024\035\024\030\036\022\021\026\035\034\027\t\b \027\024\r\024\024\002\ \030\026)Tj 0 Tw (-)Tj 0.235 Tw T* (\024\r\026\027\017\005 \017\031\004\026\035\026\f\034 \002\024\035\036\ \036 \004\036\021\r\036\030\021\017 \r\036\022\026. \200)Tj /Span<>> BDC ( )Tj EMC (\030\026\027\027\036\005 )Tj 0.283 Tw 23.244 64.543 Td [(\030\026\002\024\021\036 Mal)-15.9(akout)-32(i S. )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC [(\f\024\026\r\021. )0.5(\024\006\036\027\017\035\017 \220\022\f\023\030\036\f\f\017\033 )]TJ 0.059 Tw T* (\215\230\206\030\215 \f)Tj /Span<>> BDC ( )Tj EMC [(\023\024\n\024\013\034\033 \017\n\n\031\027\024\020\017\f\021\024\b\017\n\ \017\004\036\f\022\024\020\024 )0.5(\024\022\030\026\001\017)]TJ 0 Tw (-)Tj 0.021 Tw T* (\r\026\027\017\016 \r)Tj /Span<>> BDC ( )Tj EMC (\024\002\030\026\006\026\b \021\022\026\027\036\005 \027\024\030\n\026\035\ \034\027\024\005 \f\035\017\017\f\021\024\005 \024\002\024)Tj 0 Tw (-)Tj -0.022 Tw T* (\035\024\004\022\017 \021\024\035\f\021\024\005 \022\017\001\022\017, \023\ \024\035\017\023\024\r \017)Tj /Span<>> BDC ( )Tj EMC (\022\024\035\024\030\036\022\021\026\035\034\027\024\005 \022\026\030)Tj 0 Tw (-)Tj -0.029 Tw T* (\006\017\027\024\n\t, \031\007\026\035\036\027\027\t\b \024\021 \024\007\ \027\017\b \017)Tj /Span<>> BDC ( )Tj EMC (\021\036\b \032\036 \023\026\006\017\036\027\021\024\r [30]. )Tj 0.047 Tw T* (\200)Tj /Span<>> BDC ( )Tj EMC (\027\024\030\n\026\035\034\027\024\005 \021\024\035\f\021\024\005 \022\017\ \001\022\036 94,3% \024\002\030\026\006\024\r \021\022\026\027\036\005 \ )Tj 0.108 Tw 0 -1.218 TD (\002\t\035\017 \024\021\030\017\006\026\021\036\035\034\027\t\n\017 \r)Tj /Span<>> BDC ( )Tj EMC (\024\021\027\024\001\036\027\017\017 \017\n\n\031\027\024\030\036\026\022\ \021\017\r)Tj 0 Tw (-)Tj 0.039 Tw 0 -1.218 TD (\027\024\f\021\017 \215\230\206\030\215. \200)Tj /Span<>> BDC ( )Tj EMC (\023\024\035\017\023\026\b \021\024\035\f\021\024\005 \022\017\001\022\017\ \021\024\035\034\022\024 22,6% )Tj 0.316 Tw T* (\022\035\036\021\024\022 \023\024\022\026\026\035\017 \023\024\035\024\032\ \017\021\036\035\034\027\024\036 \017\n\n\031\027\024\024\022\030\026\001\ \017\r\026)Tj 0 Tw (-)Tj 0.168 Tw T* (\027\017\036, \021\024\020\007\026 \022\026\022 91,5% \024\002\030\026\006\ \024\r \030\026\022\026 \021\024\035\f\021\024\005 \022\017\001\022\017 \ )Tj 0.138 Tw T* [(\002\t\035\017 \023\024\035\024\032\017\021\036\035\034\027\t\n\017 )0.5(\027\026)]TJ /Span<>> BDC ( )Tj EMC (\215\230\206\030\215. \200)Tj /Span<>> BDC ( )Tj EMC 15.514 0 Td [(\f\035\031\004\026\036 )0.5(\023\024\035\017\023\024\r )]TJ -0.032 Tw -15.514 -1.218 Td (\017\027\021\036\027\f\017\r\027\024\f\021\034 \024\022\030\026\001\017\r\ \026\027\017\016 \f\024\f\021\026\r\035\016\035\026 1-3+; \024\007\027\026\ \022\024 )Tj 0.244 Tw 0 -1.218 TD (\r\f\036 \024\002\030\026\006\t \026\007\036\027\024\022\026\030\006\017\ \027\024\n\t \024\022\030\026\001\017\r\026\035\017\f\034 \f)Tj /Span<>> BDC ( )Tj EMC (\017\027)Tj 0 Tw (-)Tj 0.124 Tw 0 -1.218 TD (\021\036\027\f\017\r\027\024\f\021\034\033 4+. \200)Tj /Span<>> BDC ( )Tj EMC (\023\024\035\024\032\017\021\036\035\034\027\t\b \024\002\030\026\006\026\ \b \017\n\n\031)Tj 0 Tw (-)Tj 0.12 Tw 0 -1.218 TD [(\027\024\030\036\026\022\021\017\r\027\024\f\021\034 )0.5(\023\030\017\f\031\021\f\021\r\024\r\026\035\026 \023\024)]TJ /Span<>> BDC ( )Tj EMC (\r\f\036\005 \006\017\021\024\023\035\026\n\036 )Tj 0.199 Tw T* (\032\036\035\036\017\f\021\024\020\024 \220\023\017\021\036\035\017\016\ . \224\021\017 \030\036\031\035\034\021\026\021\t \023\024\022\026\t\r\ \026\033\021, )Tj -0.033 Tw T* [(\004\021\024 )0.5(\220\022\f\023\030\036\f\f\017\016 )0.5(\215\230\206\030\215 )0.5(\023\024\r\t\001\036\027\026 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 14.299 0 Td [(\021\022\026\027\017 )0.5(\030\026\022\026 )0.5(\021\024\035\f\021\024\005 )]TJ -0.069 Tw -14.299 -1.218 Td (\022\017\001\022\017 \023\024)Tj /Span<>> BDC ( )Tj EMC (\f\030\026\r\027\036\027\017\033 \f)Tj /Span<>> BDC ( )Tj EMC (\027\024\030\n\026\035\034\027\024\005 \f\035\017\017\f\021\024\005 \024\ \002\024\035\024\004)Tj 0 Tw (-)Tj 0.027 Tw T* (\022\024\005 \021\024\035\f\021\024\005 \022\017\001\022\017 \017)Tj /Span<>> BDC ( )Tj EMC (\023\024\035\017\023\026\n\017. \025\030\024\n\036 \021\024\020\024, \220\ \022\f\023\030\036\f)Tj 0 Tw (-)Tj -0.003 Tw T* (\f\017\016, \023\024-\r\017\007\017\n\024\n\031, \r\t\001\036 \r)Tj /Span<>> BDC ( )Tj EMC (\023\024\035\017\023\026\b, \004\036\n \r)Tj /Span<>> BDC ( )Tj EMC (\027\024\030\n\026\035\034\027\024\005 )Tj 0.328 Tw T* [(\021\024\035\f\021\024\005 \022\017\001\022\036. \037\036\035\034\033 \017\ \f\f\035\036\007\024\r\026\027\017\016 Nishihar)-33(a M. )]TJ 0.027 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. \002\t\035\024 \r\t\016\f\027\036\027\017\036 \f\r\016\ \017 \215\230\206\030\215 \f)Tj /Span<>> BDC ( )Tj EMC (\024\027\022\024\020\036\027\036\024\n )Tj 0.254 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC 1.004 0 Td [(\023\030\024\020\030\036\f\f\017\030\024\r\026\027\017\036\n )0.6(\022\024\035\024\030\036\022\021\026\035\034\027\024\005 )0.6(\026\007\036\027\024\022\026\030\006\017)]TJ 0 Tw (-)Tj -0.021 Tw -1.004 -1.218 Td (\027\024\n\t [31]. \222\n\n\031\027\024\020\017\f\021\024\b\017\n\017\016\ , \n\036\021\024\007\t \020\017\002\030\017\007\017\026\006\017\017 )Tj 0.14 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC [(\023\024\035\017\n\036\030\026\027\024\005 )0.5(\006\036\023\027\024\005 )0.5(\030\036\026\022\006\017\017 \f)]TJ /Span<>> BDC ( )Tj EMC 15.213 0 Td [(\024\002\030\026\021\027\024\005 )0.5(\021\030\026\027\f)]TJ 0 Tw (-)Tj 0.363 Tw -15.213 -1.218 Td (\022\030\017\023\006\017\036\005 \017\f\023\024\035\034\024\r\026\035\017\ \f\034 \007\035\016 \024\006\036\027\022\017 \220\022\f\023\030\036\f\f\017\ \017 )Tj 0.228 Tw T* (\215\230\206\030\215 \r)Tj /Span<>> BDC ( )Tj EMC (\024\027\022\024\021\030\026\027\f\235\024\030\n\017\030\024\r\026\027\027\ \024\005 \022\024\035\024\030\036\022\021\026\035\034\027\024\005 )Tj 0.156 Tw T* [(\021\022\026\027\017. )0.6(\203\017 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 5.397 0 Td [(\024\007\027\024\005 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 4.246 0 Td [(\026\007\036\027\024\n )0.5(\235\024\027\024\r\024\020\024 )0.6(\027\036\024\023\031\b\024\035\036)]TJ 0 Tw (-)Tj 0.248 Tw -9.643 -1.218 Td (\r\024\020\024 \220\023\017\021\036\035\017\016 \f\035\017\017\f\021\024\ \005 \024\002\024\035\024\004\022\017 \027\036 \002\t\035\024 \r\t\016\r\ )Tj 0 Tw (-)Tj 0.232 Tw T* (\035\036\027\024 \017\n\n\031\027\024\024\022\030\026\001\017\r\026\027\017\ \016 \215\230\206\030\215. \203\026\023\030\024\021\017\r, \215\230\206\030\ \215 )Tj 0.313 Tw T* [(\220\022\f\023\030\036\f\f\017\030\024\r\026\035\f\016 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC (94,4% \022\024\035\024\030\036\022\021\026\035\034\027\t\b \026\007\036\027\ \024)Tj 0 Tw (-)Tj 0.301 Tw T* (\022\026\030\006\017\027\024\n. \222\n\n\031\027\024\030\036\026\022\021\ \017\r\027\024\f\021\034 \215\230\206\030\215 \002\t\035\026 \r\t\001\036\ )Tj 0.037 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\027\017\022\024\007\017\235\235\036\030\036\027\006\017\030\024\r\026\027\ \027\t\b \026\007\036\027\024\022\026\030\006\017\027\024\n\026\b, \004\036\ \n )Tj 0.337 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC 1.043 0 Td [(\r\t\f\024\022\024\007\017\235\235\036\030\036\027\006\017\030\024\r\026\ \027\027\t\b. )0.6(\224\022\f\023\030\036\f\f\017\016 )0.6(\215\230\206\030\215 )]TJ 0.351 Tw -1.043 -1.218 Td (\027\026\004\017\021\036\035\034\027\024 \022\024\030\030\036\035\017\030\ \024\r\026\035\026 \f)Tj /Span<>> BDC ( )Tj EMC (\007\017\235\235\036\030\036\027\006\017\030\024\r\022\024\005, )Tj 0.04 Tw T* (\035\017\n\235\026\021\017\004\036\f\022\024\005 \017\027\r\026\017\036\ \005, \n\036\021\026\f\021\026\026\n\017 \r)Tj /Span<>> BDC ( )Tj EMC (\035\017\n\235\026\021\017\004\036)Tj 0 Tw (-)Tj 0.131 Tw T* [(\f\022\017\036 \031\035\t, \n\036\021\026\f\021\026\026\n\017 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC (\023\036\004\036\027\034 \017)Tj /Span<>> BDC ( )Tj EMC 15.2 0 Td (\022\035\026\f\f\017\235\017\022\026\006\017\036\005 )Tj 0.122 Tw -15.2 -1.218 Td [(Duk)10(es. )0.5(\230\030\026\027\f\022\030\017\023\021\t )0.6(\215\230\206\030\215 )0.5(\021\026\022\032\036 )0.5(\002\t\035\017 )0.6(\024\002\027\026\030\031\032\036\027\t )]TJ -0.015 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\030\036\036\006\017\030\024\r\026\027\027\t\b \022\024\035\024\030\036\ \022\021\026\035\034\027\t\b \026\007\036\027\024\022\026\030\006\017\027\ \024\n\026\b )Tj 0.09 Tw T* (\004\036\035\024\r\036\022\026 \f)Tj /Span<>> BDC ( )Tj EMC [(\023\024\n\024\013\034\033 R)-12(T-PCR. \224\021\017 \007\026\027\027\t\036 \f\r\017\007\036\021\036\035\034\ )]TJ 0 Tw (-)Tj 0.21 Tw T* (\f\021\r\031\033\021 \024)Tj /Span<>> BDC ( )Tj EMC (\021\024\n, \004\021\024 \215\230\206\030\215 \f\r\016\026\027 \f)Tj /Span<>> BDC ( )Tj EMC (\022\026\027\006\036\030\024\020\036\027\036\024\n, )Tj 0.32 Tw T* (\007\017\235\235\036\030\036\027\006\017\030\024\r\022\024\005, \023\030\ \024\020\030\036\f\f\017\030\024\r\026\027\017\036\n \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\020\027\024)Tj 0 Tw (-)Tj T* (\024\n \022\024\035\024\030\036\022\021\026\035\034\027\t\b \026\007\036\ \027\024\022\026\030\006\017\027\024\n.)Tj /T1_1 1 Tf 0.094 Tw 0 -2.436 TD (\022\002\f\001 \200\020\027\006\200 )Tj /Span<>> BDC ( )Tj EMC (\212\006\002\n\006\r\217\217\t\t \220\f\r\003\002\201\b\002\n\002 \204\t\ \220\f\004, \212\006\002)Tj 0 Tw (-)Tj 0.232 Tw 0 -1.218 TD (\f\t\226\r\006\004\204\t\t \t)Tj /Span<>> BDC ( )Tj EMC (\214\t\n\006\004\204\t\t \220\f\r\003\002\220 \220\002\f\002\006\r\220\003\ \004\f\001\b\002\n\002 )Tj 0 Tw T* (\006\004\220\004)Tj /T1_0 1 Tf 0.089 Tw T* (\230\024\021 \235\026\022\021, \004\021\024 \215\230\206\030\215 \017)Tj /Span<>> BDC ( )Tj EMC (\036\020\024 \030\036\006\036\023\021\024\030 PTHR1 \002\t\035\017 \024\002\ )Tj 0 Tw (-)Tj 0.015 Tw T* (\027\026\030\031\032\036\027\t \r)Tj /Span<>> BDC ( )Tj EMC (\027\024\030\n\026\035\034\027\024\n \017)Tj /Span<>> BDC ( )Tj EMC (\021\024\035\f\021\024\022\017\001\036\004\027\024\n \220\023\017\021\036\ \035\017\017 )Tj 0.078 Tw T* ([32], \016\f\027\024 \031\022\026\t\r\026\036\021 \027\026)Tj /Span<>> BDC ( )Tj EMC (\021\024, \004\021\024 \215\230\206\030\215 \016\r\035\016\036\021\f\016\ \235\026\022)Tj 0 Tw (-)Tj 0.162 Tw T* (\021\024\030\024\n, \022\024\021\024\030\t\005 \007\036\005\f\021\r\031\036\ \021 \022\026\022 \035\024\022\026\035\034\027\t\005 \030\036\020\031\035\ \016\021\024\030 )Tj 0.121 Tw T* [(\023\024\f\030\036\007\f\021\r\024\n )0.6(\023\026\030\026\022\030\017\027\027\024\020\024/\026\031\021\024\022\030\ \017\027\027\024\020\024 )0.6(\023\031\021\017 )0.6([33]. )]TJ 0.168 Tw T* [(\224\021\017 )0.5(\017\f\f\035\036\007\024\r\026\027\017\016 )0.5(\r\n\036\f\021\036 )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC 11.973 0 Td [(\007\030\031\020\017\n\017, )0.5(\023\030\024\r\036\007\036\027\027\t\n\017 )]TJ /T1_2 1 Tf 0.189 Tw -11.973 -1.218 Td (in vitro)Tj /T1_0 1 Tf ( [34], \023\030\036\007\024\f\021\026\r\017\035\017 \017\027\235\024\030\ \n\026\006\017\033 \024)Tj /Span<>> BDC ( )Tj EMC (\021\024\n, \022\026\022 )Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0 Tw 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\214)10(\211\036\033 \035\030\032\t\033)30(\b)42(\032)-21(\240\033\233)]TJ 57.136 0 Td (REVIEW)Tj -57.136 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 23, \023\0221)69(, 202)69(4)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 23, \023\0221)69(, 202)69(4)]TJ /T1_4 1 Tf 25 0 0 25 20.8652 56.0378 Tm (164)Tj ET endstream endobj 461 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\037)31(\025\007\025\002\016\n)-10(\026)11(\013\007\216\001\020\203 \002\013\n, \013\006\006\025\227\220\220\002\025\ \r\013\001\001\020\203 \006\022\221\013\002\013\026\202)10(\025\002\024\025\001-)]TJ 0 -1 TD [(\002\025\201\006)-10(\026\r\016\001\001\020\024 \221\002\025\026)11(\016\220\001\025\024 \(\025\f\222\025\002 \007\220\026)11(\016\002\013\026)-19.9(\215\002\020\))]TJ 42.257 1 Td [(Color)31(ectal cancer associated with par)21(ath)31(yr)20(oid )]TJ 4.983 -1 Td [(h)11(ormone)-52(-r)31.1(elated pr)20(otein \(r)31(e)11(vie)11(w\))]TJ ET 0 0 0 1 K 1 j 1 J [0 2.997]0 d /GS1 gs q 1 0 0 1 46.0167 660.8533 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 43.0197 660.8533 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q [0 2.997]0 d q 1 0 0 1 46.0167 633.2455 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 43.0197 633.2455 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q 0 j 0 J q 1 0 0 1 42.5197 569.5764 cm 0 0 m 453.543 0 l S Q BT 0 0 0 1 k /T1_1 1 Tf -0.018 Tw 9 0 0 9 90.7087 730.4919 Tm [(an agg)14(ressiv)13(e pheno)13(type; the w)12(ork also descr)-36.9(ibes molecular mechanis)33.1(ms in)10.9(v)13(olv)12.9(ed in these p)46(rocesses. There is a g)14(row)]TJ 0 Tw (-)Tj 0.042 Tw 0 -1.111 TD [(ing interest to use this rather uniq)14(ue p)46(ro)13(tein in therapies, which deter)-13.9(mines activ)13(e dev)13(elopment of phar)-14(maceutical )]TJ -0.008 Tw T* [(substances )0.5(based on )0.5(analogues of )0.5(this p)46(ro)13(tein. )0.5(The f)-43(inal goal )0.5(is to adv)16.1(ance the dev)13(elopment of ef)-39.9(fectiv)13(e therapeutic )]TJ 0.023 Tw T* [(strategies, which could im)16(p)46(rov)13(e the treatment results of colorectal cancer in patients.)]TJ /T1_2 1 Tf 0.01 Tc -0.01 Tw 8 0 0 8 42.5596 685.2226 Tm [(KEYW)22(ORDS:)]TJ /T1_1 1 Tf 0 Tc 0.023 Tw 4.948 0 Td [( colorectal cancer)61.1(, parath)12(yroid hor)-14(mone-related p)46(ro)13(tein)]TJ /T1_2 1 Tf 0.01 Tc 0.018 Tw -4.948 -1.909 Td [(C)19(ONFL)-33(ICT)5( OF)5( INTE)25(REST)62(:)]TJ /T1_1 1 Tf 0 Tc 0.023 Tw 9.871 0 Td [( The authors declare no conf)-22(lict of interest)]TJ /T1_2 1 Tf 0.037 Tc 0.021 Tw -9.871 -2.617 Td [(F)3.2(O)-4.6(R)8.7( C)-17.4(I)-15.6(T)45.4(A)37.5(T)-24.5(I)-1.2(ON:)]TJ /T1_3 1 Tf 0.023 Tc 0.03 Tw 6.465 0 Td [( K)-15.9(u)-7.6(r)-42.9(z)-27.5(a)-7.6(n)-11.9(o)-10.3(v)]TJ /Span<>> BDC ( )Tj EMC [(A)-23(.)-1.9(N)-2.7(.)-23.5(, D)-15.2(u)-7.5(r)-32.6(l)-23.7(e)-22.8(s)-8.8(h)-17.2(t)-24.7(e)-12.1(r)]TJ /Span<>> BDC ( )Tj EMC [(V)39.7(.)-7.3(M)-7.1(.)-23.5(, B)-18.6(y)-21.9(k)-3.7(o)-10.3(v)]TJ /Span<>> BDC ( )Tj EMC [(M)-7.1(.)-9.8(I)-10.3(. C)-16.4(o)-15.6(l)-20.8(o)-11.9(r)-19.1(e)-19.1(c)-41.5(t)-36.7(a)-11.4(l c)-21.5(a)-7.6(n)-10.1(c)-9.6(e)-12.1(r a)-26.6(s)-22.3(s)-19.1(o)-16.8(c)-38.2(i)-5.1(a)-18.2(t)-24.7(e)-21(d w)-45.7(i)-15.8(t)-26.1(h p)-20(a)-10.2(r)-30.8(a)-18.2(t)-26.1(h)-14.9(y)-32.2(r)-15.8(o)-12.5(i)-8.8(d h)-10.9(o)-11.8(r)-35.9(m)-12.4(o)-9.2(n)-16.1(e)-31(-)-15.9(r)-19.1(e)-18(l)-37.8(a)-18.2(t)-24.7(e)-21(d p)-13.7(r)-15.8(o)-15.8(t)-24.7(e)-19.1(i)-3.2(n)23( )]TJ -0.016 Tc 0.016 Tw -6.47 -1.2 Td [(\(r)-58.1(e)-54.8(v)-90.8(i)-50(e)-51.5(w)-19.4(\))-28.6(.)-39.3( )]TJ /T1_1 1 Tf 0.033 Tc -0.033 Tw 4.166 0 Td [(K)13.9(ol)3.6(op)2.4(r)3.1(o)3.4(k)-19.2(t)2.2(ol)3.6(o)-3.3(g)-13.2(i)6.7(a)5.8(.)]TJ /T1_3 1 Tf 0.013 Tc 0.034 Tw 7.019 0 Td [( 2)-18.9(0)-13.8(2)-1.2(4;2)-20.3(3)-4(\()27.7(1)34.3(\))4.6(:)10.9(1)2.6(6)-8.2(2\226)40.8(1)14.2(7)2.6(1)-5.8(.)-10.3( \()-10.9(i)-13.2(n)-10.3( R)-16.5(u)-31.9(s)-32.2(s)-25.5(.)33.2(\).)-10.3( h)-27.2(t)-59.4(t)-39.4(p)-28.7(s)-18(:)-8(/)74.7(/)26.4(d)-21.1(o)-22.5(i)-10.2(.)-7.3(o)-21.8(r)-26.7(g)-32.8(/)1.2(1)4(0)-3.5(.)-15.6(3)-2(3)-25.9(8)-8.7(7)-5.4(8)-10(/)-2.1(2)-18.9(0)-0.7(7)-11.9(3)-23.3(-)31.2(7)0.7(5)-9.6(5)-18.9(6)-36.7(-2)-18.9(0)-13.8(2)-1.2(4)-38.5(-2)-20.3(3)-23.3(-)45.1(1)16.9(-)45.2(1)2.6(6)-8.2(2)2.1(-)45.1(1)14.2(7)2.6(1)]TJ /T1_2 1 Tf 0.01 Tc 0.334 Tw -11.18 -2.617 Td [(\026\020\021\033\030)5( \020\036\017)5( \013\033\021\033\013\023\030\037\023:)]TJ /T1_1 1 Tf 0 Tc 0.339 Tw 11.208 0 Td [( \222\205\032\016\026\021\n\027 \201\021\026\024\n\023\025\017 \217\025\013\ \n\023\026\031\027\025\006, \225\210\213\255\214 \216\255 \253\222\205\005\ \026\021\t\013\025\017 \202\n\t\205\030\026\032\t\024\027\031\021\021\020\ \017 )0.5(\003\031\030\025\203\025\021\t\013\025\017 \205\021\025\027\031\032\t\025\ \024\031\024\273 )]TJ 0.027 Tw -11.213 -1.2 Td (\240\025\021\025\t\024\031\032\t\024\027\026 \016\030\032\026\027\n\n\004\ \032\026\021\031\021\025\002 \212\n\t\t\025\017\t\013\n\017 \225\031\030\ \031\032\026\203\025\025, \205\023.)Tj /Span<>> BDC ( )Tj EMC (\240\025\024\032\n\f\026\021\026 \207\031\030\025\021\026, \030.)Tj /Span<>> BDC ( )Tj EMC (4, \222\032\026\t\021\n\030\026\032, 350063, \212\n\t\t\025\002; \024\031\ \023.:)Tj /Span<>> BDC ( )Tj EMC (+7 \(988\) 247-12-)Tj 0.023 Tw 0 -1.2 TD (76; e-mail: kurzanov@mail.ru)Tj /T1_2 1 Tf 0.01 Tc 0.043 Tw 0.005 -1.2 Td [(ADDRESS)5( F)13(OR)5( C)19.1(ORRESPONDEN)23(CE:)]TJ /T1_1 1 Tf 0 Tc 0.048 Tw 14.101 0 Td [( K)17(ur)-16(zanov Anatoliy Nik)13(olaevich, K)17(uban S)28.1(tate Medical U)22(niv)13(ersity of the R)22(ussian Health Ministr)-43(y)42(, Sedina st., 4, )]TJ 0.023 Tw -14.106 -1.2 Td [(Krasnod)26(ar)61.1(, 350063, R)22(ussia;)]TJ /Span<>> BDC ( )Tj EMC [(tel.: +7 \(988\) 247-12-76; e-mail: kur)-16(zanov@mail.ru)]TJ 0 Tw 0 -2.792 TD (\200\026\024\026 \033\n\t\024\205\033\023\031\021\025\002)Tj /Span<>> BDC ( )Tj EMC (\227 18.09.2023)Tj /Span<>> BDC ( )Tj EMC 19.488 0 Td (\n\t\023\031 \030\n\032\026\005\n\024\013\025)Tj /Span<>> BDC ( )Tj EMC (\227 19.12.2023)Tj /Span<>> BDC ( )Tj EMC 18.78 0 Td (\032\025\021\002\024\n \013)Tj /Span<>> BDC ( )Tj EMC (\033\205\005\023\025\013\026\203\025\025)Tj /Span<>> BDC ( )Tj EMC (\227 12.02.2024)Tj ( )Tj -38.268 -1.375 Td (Received)Tj /Span<>> BDC ( )Tj EMC (\227 18.09.2023)Tj /Span<>> BDC ( )Tj EMC 19.488 0 Td (Revised)Tj /Span<>> BDC ( )Tj EMC (\227 19.12.2023)Tj /Span<>> BDC ( )Tj EMC 18.78 0 Td (Accepted for publication)Tj /Span<>> BDC ( )Tj EMC (\227 12.02.2024)Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 42.5896 505.6259 Tm (\023\023\034\226\034\022\031\034)Tj 0 0 0 1 k /GS1 gs /T1_3 1 Tf 0 Tc 0.028 Tw 10 0 0 10 42.5197 481.2699 Tm (\025\024\035\024\030\036\022\021\026\035\034\027\t\005 \030\026\022 \(\025\ \217\) \024\f\021\026\036\021\f\016 \021\030\036\021\034\017\n \027\026\017\ \002\024\035\036\036 )Tj -0.009 Tw 0 -1.218 TD (\030\026\f\023\030\024\f\021\030\026\027\036\027\027\t\n \021\017\023\024\ \n \030\026\022\026 \017)Tj /Span<>> BDC ( )Tj EMC (\026\027\017\n\026\036\021 \r\021\024\030\024\036 \n\036)Tj 0 Tw (-)Tj 0.024 Tw T* (\f\021\024 \023\024)Tj /Span<>> BDC ( )Tj EMC (\f\n\036\030\021\027\024\f\021\017 \(9,4% \f\030\036\007\017 \r\f\036\b \ \f\n\036\030\021\036\005 \024\021 \030\026\022\026\) )Tj 0.203 Tw T* (\f\024\020\035\026\f\027\024 \020\035\024\002\026\035\034\027\024\005 \f\ \021\026\021\017\f\021\017\022\036 \030\026\022\026 [1]. \200\036\007\031\ \013\036\005 )Tj 0.329 Tw T* (\023\030\017\004\017\027\024\005 \f\n\036\030\021\017 \023\026\006\017\036\ \027\021\024\r \017)Tj /Span<>> BDC ( )Tj EMC (\030\036\006\017\007\017\r\024\r \016\r\035\016\036\021)Tj 0 Tw (-)Tj 0.101 Tw T* (\f\016 \023\024\016\r\035\036\027\017\036 \027\024\r\t\b \023\024\007\021\ \017\023\024\r \025\217\217 \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\017\024\002\030\036\021\036\027\027\026\016 )Tj 0.165 Tw T* (\030\036\017\f\021\036\027\021\027\024\f\021\034 \022)Tj /Span<>> BDC ( )Tj EMC (\017\f\023\024\035\034\031\036\n\t\n \r)Tj /Span<>> BDC ( )Tj EMC (\027\026\f\021\024\016\013\036\036 \r\030\036\n\016 )Tj 0.146 Tw T* (\n\036\021\024\007\026\n \035\036\004\036\027\017\016 [2]. \200)Tj /Span<>> BDC ( )Tj EMC 10.423 0 Td [(\006\036\035\024\n \025\217\217 )0.5(\b\026\030\026\022\021\036\030\017\031\036\021\f\016 )]TJ 0.161 Tw -10.423 -1.218 Td [(\r\t\f\024\022\024\005 \020\036\021\036\030\024\020\036\027\027\024\f\021\ \034\033 \017-\026 \r\035\017\016\027\017\016 )0.5(\030\026\035\017\004\027\t\b )]TJ 0.473 Tw T* (\020\036\027\036\021\017\004\036\f\022\017\b \235\026\022\021\024\030\024\ \r \017)Tj /Span<>> BDC ( )Tj EMC (\235\026\022\021\024\030\024\r \024\022\030\031\032\026\033\013\036\005 \ )Tj 0.028 Tw T* (\f\030\036\007\t [3]. \025)Tj /Span<>> BDC ( )Tj EMC (\235\026\022\021\024\030\026\n, \f\r\016\026\027\027\t\n \f)Tj /Span<>> BDC ( )Tj EMC (\022\024\035\024\030\036\022\021\026\035\034\027\t\n )Tj 0.197 Tw T* (\024\027\022\024\020\036\027\036\024\n, \024\021\027\024\f\016\021\f\016\ \023\024\r\030\036\032\007\036\027\017\036 \021\022\026\027\017 \022\017\ \001\036\004)Tj 0 Tw (-)Tj 0.179 Tw T* (\027\017\022\026, \027\026\035\017\004\017\036 \023\026\021\024\020\036\027\ \027\t\b \n\017\022\030\024\024\030\020\026\027\017\n\024\r \017)Tj /Span<>> BDC ( )Tj EMC (\023\036\030)Tj 0 Tw (-)Tj 0.229 Tw T* (\f\017\f\021\036\027\006\017\016 \r\024\f\023\026\035\017\021\036\035\034\ \027\t\b \030\036\026\022\006\017\005, \022\024\021\024\030\t\036 \n\024\ \020\031\021 )Tj 0.226 Tw T* (\023\030\017\r\024\007\017\021\034 \022)Tj /Span<>> BDC ( )Tj EMC (\023\030\036\007\030\026\022\024\r\t\n \023\024\030\026\032\036\027\017\016\ \n, \023\030\024\020\030\036\f\f\017)Tj 0 Tw (-)Tj 0.084 Tw T* (\030\031\033\013\017\n \r)Tj /Span<>> BDC ( )Tj EMC (\f\021\024\030\024\027\031 \027\024\r\024\024\002\030\026\024\r\026\027\ \017\016 [4]. \200\026\032\027\024, \004\021\024 )Tj 0.527 Tw T* [(\027\036\024\023\035\026\f\021\017\004\036\f\022\017\036 )0.5(\022\035\036\021\022\017 \027\026\b\024\007\016\021\f\016 \023\024\007 \f\ \017\035\034\027\t\n )]TJ 0.358 Tw T* [(\r\035\017\016\027\017\036\n \r\027\036\022\035\036\021\024\004\027\024\020\ \024 )0.5(\n\026\021\030\017\022\f\026 \017)]TJ /Span<>> BDC ( )Tj EMC (\024\022\030\031\032\026\033\013\017\b )Tj 0.137 Tw T* [(\022\035\036\021\024\022, )0.5(\017\r\036\f\021\027\t\b )0.6(\r\n\036\f\021\036 )0.5(\022\026\022 )0.5(\n\017\022\030\024\024\022\030\031\032\036\027\017\036 )0.6(\024\023\031)]TJ 0 Tw (-)Tj 0.029 Tw T* (\b\024\035\017 [5,6]. \212\r\031\f\021\024\030\024\027\027\016\016 \f\r\016\ \034 \n\036\032\007\031 \024\023\031\b\024\035\034\033 \017)Tj /Span<>> BDC ( )Tj EMC (\036\036 )Tj 0.377 Tw T* (\n\017\022\030\024\024\022\030\031\032\036\027\017\036\n \024\f\031\013\036\ \f\021\r\035\016\036\021\f\016 \026)Tj /Span<>> BDC ( )Tj EMC (\f\004\036\021 \r\t\f\r\024)Tj 0 Tw (-)Tj 0.362 Tw T* (\002\024\032\007\036\027\017\016 \026\031\021\024\022\030\017\027\027\t\b\ \017)Tj /Span<>> BDC ( )Tj EMC (\023\026\030\026\022\030\017\027\027\t\b \235\026\022\021\024\030\024\r.\ )Tj 0.295 Tw T* (\025\026\022 \f\035\036\007\f\021\r\017\036, \r)Tj /Span<>> BDC ( )Tj EMC (\024\023\031\b\024\035\036\r\t\b \022\035\036\021\022\026\b \026\023\031\ \f\022\026\033\021\f\016 )Tj 0.173 Tw T* (\n\027\024\020\024\004\017\f\035\036\027\027\t\036 \n\024\035\036\022\031\ \035\016\030\027\t\036 \n\036\b\026\027\017\n\t, \f\023\024\f\024\002)Tj 0 Tw (-)Tj 0.097 Tw T* (\f\021\r\031\033\013\017\036 \017\b \026\020\030\036\f\f\017\r\027\t\n \f\ \023\024\f\024\002\027\024\f\021\016\n [7]. \200)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\n )Tj -0.019 Tw T* (\f\035\031\004\026\036 \024\023\031\b\024\035\036\r\t\036 \022\035\036\021\ \022\017 \007\036\n\024\027\f\021\030\017\030\031\033\021 \017\n\036\027\ \036\027\017\016 )Tj 0.01 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC [(\f\r\024\036\005 \022\035\036\021\024\004\027\024\005 )0.5(\023\024\035\016\030\027\024\f\021\017 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC [(\023\030\017\024\002\030\036\021\026\033\021 )0.5(\n\036\036\027)]TJ 0 Tw (-)Tj -0.015 Tw T* (\b\017\n\024\023\024\007\024\002\027\t\005 \235\036\027\024\021\017\023.\ \224\021\024\021 \023\030\024\006\036\f\f, \017\r\036\f\021\027\t\005 \ \022\026\022 )Tj 0.259 Tw T* (\220\023\017\021\036\035\017\026\035\034\027\024-\n\036\036\027\b\017\n\ \026\035\034\027\t\005 \023\036\030\036\b\024\007 \(\224\204\215\) \f\r\016\ )Tj 0 Tw (-)Tj 0.026 Tw T* (\t\r\026\033\021 \f)Tj /Span<>> BDC ( )Tj EMC (\023\030\017\024\002\030\036\021\036\027\017\036\n \023\030\017\027\026\ \022\024\r \030\026\022\024\r\t\b \f\021\r\024\035\024)Tj 0 Tw (-)Tj 0.073 Tw T* (\r\t\b \022\035\036\021\024\022 \(\217\221\025\) [8,9], \022\024\021\024\ \030\t\036 \023\030\036\007\f\021\026\r\035\016\033\021 \f\024\002\024\005\ )Tj -0.031 Tw T* (\235\030\026\022\006\017\033 \022\035\036\021\024\022 \024\023\031\b\024\ \035\017, \024\002\035\026\007\026\033\013\031\033 \f\023\024\f\024\002\027\ \024\f\021\034\033 )Tj 0.049 Tw T* (\022)Tj /Span<>> BDC ( )Tj EMC (\f\026\n\024\024\002\027\024\r\035\036\027\017\033, \007\017\235\235\036\ \030\036\027\006\017\030\024\r\022\036 \017)Tj /Span<>> BDC ( )Tj EMC (\035\036\022\026\030\f\021\r\036\027)Tj 0 Tw (-)Tj 0.35 Tw T* (\027\024\005 \031\f\021\024\005\004\017\r\024\f\021\017 [10]. \200\t\001\ \036\031\023\024\n\016\027\031\021\t\036 \f\024\002\t\021\017\016 )Tj 0.164 Tw 23.244 43.841 Td (\f\r\016\026\027\t \f)Tj /Span<>> BDC ( )Tj EMC (\030\026\r\017\021\017\036\n \002\024\035\036\036 \026\020\030\036\f\f\017\ \r\027\024\020\024 \235\036\027\024\021\017\023\026 )Tj 0 Tw T* (\022\035\036\021\024\022 \025\217\217.)Tj 0.101 Tw T* (\003\027\026\004\017\021\036\035\034\027\t\036 \031\f\023\036\b\017 \002\ \t\035\017 \007\024\f\021\017\020\027\031\021\t \r)Tj /Span<>> BDC ( )Tj EMC (\023\024\027\017\n\026\027\017\017 )Tj 0.293 Tw T* [(\002\017\024\035\024\020\017\017 )0.5(\025\217\217 )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC 7.58 0 Td [(\024\f\027\024\r\027\t\b )0.5(\n\036\b\026\027\017\n\024\r, )0.6(\f\r\016\026\027\027\t\b )]TJ 0.078 Tw -7.58 -1.218 Td (\f)Tj /Span<>> BDC ( )Tj EMC (\024\027\022\024\020\036\027\036\024\n \220\021\024\020\024 \026\002\024\ \035\036\r\026\027\017\016, \007\035\016 \023\024\017\f\022\026 \027\024\ \r\t\b )Tj 0.286 Tw T* (\023\024\007\b\024\007\024\r \022)Tj /Span<>> BDC ( )Tj EMC (\036\020\024 \007\017\026\020\027\024\f\021\017\022\036 \017)Tj /Span<>> BDC ( )Tj EMC (\021\036\030\026\023\017\017. \222\r\036\f\021\027\024, )Tj 0.09 Tw T* (\004\021\024 \027\036\f\022\024\035\034\022\024 \n\017\021\024\020\036\027\ \027\t\b \f\017\020\027\026\035\034\027\t\b \023\031\021\036\005 \017\020\ \030\026\033\021 )Tj 0.134 Tw T* (\022\035\033\004\036\r\031\033 \030\024\035\034 \r)Tj /Span<>> BDC ( )Tj EMC (\023\024\007\007\036\030\032\026\027\017\017 \030\024\f\021\026 \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\035\017\235\036\030\026)Tj 0 Tw (-)Tj 0.015 Tw T* (\006\017\017 \025\217\217. \202\022\021\017\r\026\006\017\016 \023\036\030\ \036\007\026\004\017 \f\017\020\027\026\035\024\r ERK1/2 MAPK )Tj 0.206 Tw T* (\024\004\036\027\034 \004\026\f\021\024 \r\f\021\030\036\004\026\036\021\ \f\016 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\025\217\217 [11]. \215\024\016\r\035\016\036\021\f\016 )Tj 0.171 Tw T* (\r\f\036 \002\024\035\034\001\036 \007\024\022\026\026\021\036\035\034\f\ \021\r \021\024\020\024, \004\021\024 \026\022\021\017\r\026\006\017\016\ \023\031\021\017 )Tj 0.035 Tw T* [(PI3K/Ak)-23.9(t )0.5(\f\r\016\026\027\026 )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC 8.209 0 Td [(\025\217\217 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 2.634 0 Td [(\n\024\032\036\021 )0.5(\023\030\036\024\002\030\026\024\r\026\021\034 )0.6(\007\017\235)]TJ 0 Tw (-)Tj 0.025 Tw -10.843 -1.218 Td [(\235\036\030\036\027\006\017\030\024\r\026\027\027\031\033 )0.5(\f\035\017\017\f\021\031\033 \024\002\024\035\024\004\022\031 \021\024\035\ \f\021\024\005 \022\017\001)]TJ 0 Tw (-)Tj 0.109 Tw T* (\022\017 \004\036\035\024\r\036\022\026 \r)Tj /Span<>> BDC ( )Tj EMC (\n\036\027\036\036 \007\017\235\235\036\030\036\027\006\017\030\024\r\026\ \027\027\t\005 \017)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\036\036 )Tj 0.24 Tw T* [(\035\024\022\026\004\036\f\021\r\036\027\027\t\005 \235\036\027\024\021\ \017\023. Ak)-24(t, \r\036\030\024\016\021\027\024, \016\r\035\016\036\021\f\016 )]TJ -0.033 Tw T* (\024\f\027\024\r\027\024\005 \022\017\027\026\024\005, \022\024\021\024\ \030\026\016 \024\023\024\f\030\036\007\031\036\021 \220\235\235\036\022\ \021\t PI3K )Tj 0.004 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC (\030\024\f\021 \017)Tj /Span<>> BDC ( )Tj EMC [(\023\030\024\020\030\036\f\f\017\030\024\r\026\027\017\036 \024\023\031\b\ \024\035\017 [12]. Ak)-24(t \f\r\036\030\b)]TJ 0 Tw (-)Tj 0.181 Tw T* (\220\022\f\023\030\036\f\f\017\030\031\036\021\f\016 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\030\026\022\036 \021\024\035\f\021\024\005 \022\017\001\022\017, \017)Tj /Span<>> BDC ( )Tj EMC (\022\024\030\030\036)Tj 0 Tw (-)Tj 0.182 Tw T* [(\035\017\030\031\036\021 )0.6(\f)]TJ /Span<>> BDC ( )Tj EMC 4.053 0 Td [(\023\030\024\035\017\235\036\030\026\006\017\036\005 )0.6(\022\035\036\021\024\022 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 11.11 0 Td (\017\027\020\017\002\017\030\024\r\026\027\017\036\n )Tj 0.154 Tw -15.163 -1.218 Td (\026\023\024\023\021\024\026, \026)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\032\036 \f)Tj /Span<>> BDC ( )Tj EMC (\030\026\035\017\004\027\t\n\017 \022\035\017\027\017\022\024-\023\026\021\ \024\035\024\020\017)Tj 0 Tw (-)Tj 0.161 Tw T* (\004\036\f\022\017\n\017 \023\026\030\026\n\036\021\030\026\n\017, \021\026\ \022\017\n\017 \022\026\022 \f\021\036\023\036\027\034 \017\027\r\026\017\ \017, )Tj 0.169 Tw T* [(\017\027\235\017\035\034\021\030\026\006\017\016 )0.5(\f\024\f\031\007\024\r, \n\036\021\026\f\021\026\017\030\024\r\026\027\017\ \036 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC (\035\017\n\235\026)Tj 0 Tw (-)Tj 0.284 Tw T* (\021\017\004\036\f\022\017\036 \031\035\t, \f\021\026\007\017\016 \024\023\ \031\b\024\035\017 \017)Tj /Span<>> BDC ( )Tj EMC (\b\017\n\017\024\030\036\017\f\021\036\027\021)Tj 0 Tw (-)Tj 0.377 Tw T* (\027\024\f\021\034 [13]. \217\036\020\031\035\016\021\024\030\024\n \024\ \002\024\017\b \f\017\020\027\026\035\034\027\t\b \023\031\021\036\005 )Tj -0.015 Tw T* [(PI3K/Ak)-23.9(t \017)]TJ /Span<>> BDC ( )Tj EMC (MAPK \016\r\035\016\036\021\f\016 \027\036\030\036\006\036\023\021\024\030\ \027\026\016 \023\030\024\021\036\017\027\021\017)Tj 0 Tw (-)Tj 0.11 Tw T* [(\030\024\017\027\022\017\027\026\026 Sr)-32(c. \215\024\f\022\024\035\034\022\031 \031)]TJ /Span<>> BDC ( )Tj EMC (80% \023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\025\217\217 )Tj 0.213 Tw T* [(\027\026\002\035\033\007\026\036\021\f\016 \027\026\030\031\001\036\027\017\ \036 \030\036\020\031\035\016\006\017\017 \220\022\f\023\030\036\f\f\017\ \017 Sr)-32(c, )]TJ 0.216 Tw T* (\004\021\024 \f\r\016\026\027\024 \f)Tj /Span<>> BDC ( )Tj EMC (\n\036\021\026\f\021\026\017\030\024\r\026\027\017\036\n \017)Tj /Span<>> BDC ( )Tj EMC (\035\036\022\026\030\f\021\r\036\027\027\024\005 )Tj 0.125 Tw T* [(\031\f\021\024\005\004\017\r\024\f\021\034\033, \017\027\020\017\002\017\ \030\024\r\026\027\017\036 Sr)-32(c \n\024\032\036\021 \002\t\021\034 \023\036\030)]TJ 0 Tw (-)Tj T* (\f\023\036\022\021\017\r\027\t\n \023\024\007\b\024\007\024\n \007\035\016\ \035\036\004\036\027\017\016 \025\217\217 [14].)Tj 0.485 Tw T* (\200 \027\026\f\021\024\016\013\036\n \024\002\024\030\036 \036\020\024\ \026\r\021\024\030\t \f\024\004\035\017 \006\036\035\036\f\024)Tj /Span<>> BDC (-)Tj EMC 0.594 Tw T* (\024\002\030\026\027\t\n \023\024\027\026\022\024\n\017\021\034 \024\021\ \036\004\036\f\021\r\036\027\027\t\b \004\017\021\026\021\036\035\036\005\ )Tj 0.243 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\017\027\235\024\030\n\026\006\017\036\005 \024)Tj /Span<>> BDC ( )Tj EMC (\r\026\017\n\024\f\r\016\017 \025\217\217 \017)Tj /Span<>> BDC ( )Tj EMC (\031\027\017\022\026\035\034\027\024\020\024 )Tj 0.408 Tw T* (\n\031\035\034\021\017\023\024\021\036\027\021\027\024\020\024 \002\017\024\ \035\024\020\017\004\036\f\022\017 \026\022\021\017\r\027\024\020\024 \235\ \026\022\021\024)Tj 0 Tw (-)Tj 0.146 Tw T* (\030\026)Tj /Span<>> BDC ( )Tj EMC (\227 \023\026\030\026\021\020\024\030\n\024\027-\030\024\007\f\021\r\036\ \027\027\024\020\024 \023\030\024\021\036\017\027\026 \(\215\230\206\030\ \215\), )Tj 0.387 Tw T* (\026\f\f\024\006\017\017\030\024\r\026\027\027\024\020\024, \023\024)Tj /Span<>> BDC ( )Tj EMC (\007\026\027\027\t\n \n\017\030\024\r\024\005 \035\017\021\036\030\026\021\ \031)Tj 0 Tw (-)Tj 0.384 Tw T* (\030\t, \f)Tj /Span<>> BDC ( )Tj EMC (\030\026\r\017\021\017\036\n \n\027\024\020\017\b \r\017\007\024\r \024\ \027\022\024\026\002\024\035\036\r\026\027\017\005. )Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 0 Tw 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\214)10(\211\036\033 \035\030\032\t\033)30(\b)42(\032)-21(\240\033\233)]TJ 57.136 0 Td (REVIEW)Tj /T1_5 1 Tf 25 0 0 25 505.4895 56.0378 Tm (163)Tj ET endstream endobj 458 0 obj [464 0 R] endobj 459 0 obj <>stream q /GS0 gs /Fm0 Do Q 0 0 0 1 K 1 j 1 J [0 2.997]0 d /GS1 gs q 1 0 0 1 74.3631 342.0104 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 71.3661 342.0104 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q [0 2.997]0 d q 1 0 0 1 74.3631 314.4026 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 71.3661 314.4026 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q BT 0 0 0 1 k /T1_0 1 Tf 10 0 0 10 70.8661 724.8299 Tm (https://doi.org/10.33878/2073-7556-2024-23-1-162-171)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0.023 Tw 19 0 0 19 74.9304 695.3259 Tm [(\037)31(\025\007\025\002\016\n)-10(\026)11(\013\007\216\001\020\203 \002\013\n, \013\006\006\025\227\220\220\002\025\ \r\013\001\001\020\203 \006\022)-23.3(\221\013\002\013\026\202)10.1(\025\002\024\025\001-)]TJ 2.36 -1.105 Td [(\002\025\201\006)-10(\026\r\016\001\001\020\024 \221\002\025\026)11(\016\220\001\025\024 \(\025\f\222\025\002 \007\220\026)11(\016\002\013\026)-19.9(\215\002\020\))]TJ 0 0 0 1 k /GS1 gs 0 Tw 14 0 0 14 70.8661 649.822 Tm [(\037)62(\215\002)31(\222\013\001\025\r\022)-23.2(\b)-31(.\213.)]TJ 8.162 0 0 8.162 155.4013 654.484 Tm (1)Tj 0.023 Tw 14 0 0 14 160.0372 649.822 Tm [(, \255\215\002\007\016\026)11.1(\016\002\022)-23.3(\004.\005.)]TJ -0.069 Tc 0.069 Tw 8.162 0 0 8.162 263.4622 654.484 Tm [(1,)-69(3)]TJ 0 Tc 0.023 Tw 14 0 0 14 274.7828 649.822 Tm [(, \214\020\n)10(\025\r\022)-23.2(\005.\030.)]TJ -0.069 Tc 0.069 Tw 8.162 0 0 8.162 350.5297 654.484 Tm [(1,)-69(2)]TJ 0 Tc 0 Tw 5.83 0 0 5.83 70.8661 635.4827 Tm (1)Tj 0.023 Tw 10 0 0 10 74.1775 632.1527 Tm [(\210\031\214)21(\036)20(\240 \004\036 \253\037)62(\215\f\013\001\006\n\220\203 \202)10(\025\006\215\201\013\002\006)-9.9(\026\r\016\001\001\020\203 \024\016\201\220\227\220\001\006\n\220\203 \215\ \001\220\r\016\002\006\220\026)11(\016\026\273 \005\220\001\220\006)-10(\026)11(\016\002\006)-10(\026\r\013 \222\201\002\013\r\025\025\207\002\013\001\016\001\220\205 )]TJ -0.331 -1.2 Td [(\033\025\006\006\220\203\006\n)10(\025\203 \210\016\201\016\002\013\227\220\220 \(\215\007.\022)-23.3(\005\220\026\002\025\225\013\001\013 \021\016\201\220\001\013, \201.\022\ )-23.2(4. \202)62(.\022)-23.3(\037)20(\002\013\006\001\025\201\013\002)-32(, 350063, \033\025\006\006\220\205\))]TJ 0 Tw ( )Tj 5.83 0 0 5.83 70.8661 611.4827 Tm (2)Tj 0.023 Tw 10 0 0 10 74.1775 608.1527 Tm [(\031\214)42(\240)31(\211 \253\213\013\215\017\001\025-\220\006\006)-9.9(\007\016\201\025\r\013\026)11(\016\007\216\006\n\220\203 \220\001\006)-10(\026\220\026)-19.9(\215)-20(\026\022)-23.3(\236 \037)20(\002\013\016\r\013\205 \n)-9.9(\007\220\001\220\017\016\006\n\013\205 \f\025\007\216\001\220\227\013 \023\ 1 \220\024.\022)-23.3(\221\002\025\225)-51.9(. )]TJ -0.331 -1.2 Td [(\021.\004.\022)-23.3(\036\017\013\221\025\r\006\n)10.1(\025\202)10(\025\273 \005\220\001\220\006)-10(\026)11.1(\016\002\006)-10(\026\r\013 \222\201\002\013\r\025\025\207\002\013\001\016\001\220\205 \037\ )20(\002\013\006\001\025\201\013\002\006\n)10(\025\202)10(\025 \n\002\013\205 \(\215\007.\022)-23.3(1 \005\013\205, \201.\022)-23.2(1)112(6)58(7)127(, \n)10(\025\002\221.\022)-23.2(1)68.9(, )]TJ 0 -1.2 TD [(\202)62(.\022)-23.3(\037)20(\002\013\006\001\025\201\013\002)-32(, 350086, \033\025\006\006\220\205\))]TJ 0 Tw ( )Tj 5.83 0 0 5.83 70.8661 575.4828 Tm (3)Tj 0.023 Tw 10 0 0 10 74.1775 572.1528 Tm [(\031\214)42(\240)31(\211 \037)20(\002\013\016\r\013\205 \n)-10(\007\220\001\220\017\016\006\n\013\205 \f\025\007\216\001\220\227\013 \023\ 2 \005\220\001\220\006)-9.9(\026)10.9(\016\002\006)-9.9(\026\r\013 \222\201\002\013\r\025\025\207\002\013\001\016\001\220\205 \037\ )20(\002\013\006\001\025\201\013\002\006\n)10(\025\202)10(\025 \n\002\013\205 )]TJ -0.331 -1.2 Td [(\(\215\007.\022)-23.3(\037)20(\002\013\006\001\020\207 \034\013\002\026\220\222\013\001, \201.\022)-23.3(6/2, \202)62(.\022)-23.3(\037)20(\002\013\006\001\025\201\013\002)-31.9(, 3500)87(1)125(2)138(1)69(, \033\025\006\006\220\205\))]TJ /T1_0 1 Tf 0.132 Tw 9 0 0 9 119.0551 541.6489 Tm (\037\031\023\022\007 \030\026\021\021\n\202\n \n\005\016\n\032\026 \002\027\ \023\002\031\024\t\002 \n\016\021\026\013\n\003\023\031\021\025\031 \n\024\ \031\006\031\t\024\027\031\021\021\020\004 \006\025\024\026\024\031\023\031\ \017 \t)Tj /Span<>> BDC ( )Tj EMC (\025\021\f\n\032\003\026\203\025\031\017 \n)Tj /Span<>> BDC ( )Tj EMC (\027\016\026\025\003\n\t\027\002\016\025 )Tj 0.028 Tw 0 -1.111 TD (\013\n\023\n\032\031\013\024\026\023\022\021\n\202\n \032\026\013\026 \025\ )Tj /Span<>> BDC ( )Tj EMC (\003\205\023\022\024\025\033\n\024\031\021\024\021\n\202\n \005\025\n\023\ \n\202\025\006\031\t\013\025 \026\013\024\025\027\021\n\202\n \f\026\013\ \024\n\032\026)Tj /Span<>> BDC ( )Tj EMC (\227 \033\026\032\026\024\202\n\032\003\n\021-\032\n\030\t\024\027\031\021\ )Tj 0 Tw (-)Tj 0.165 Tw T* (\021\n\202\n \033\032\n\024\031\025\021\026 \(\220\210\032\), \026\t\t\ \n\203\025\025\032\n\027\026\021\021\n\202\n, \033\n)Tj /Span<>> BDC ( )Tj EMC (\030\026\021\021\020\003 \003\025\032\n\027\n\017 \023\025\024\031\032\026\ \024\205\032\020, \t)Tj /Span<>> BDC ( )Tj EMC (\032\026\016\027\025\024\025\031\003 \003\021\n\202\025\004 \027\025\030\ \n\027 )Tj -0.034 Tw T* (\n\021\013\n\016\026\005\n\023\031\027\026\021\025\017. \230\024\n \033\031\ \032\027\020\017 \032\205\t\t\013\n\002\016\020\006\021\020\017 \n\005\016\ \n\032 \033\n)Tj /Span<>> BDC ( )Tj EMC (\030\026\021\021\n\017 \033\032\n\005\023\031\003\026\024\025\013\031, \013\ \n\024\n\032\020\017 \033\032\025\016\027\026\021 \027\021\031\t\024\025\ \t\027\n\017 )Tj 0.087 Tw T* (\027\013\023\026\030 \027)Tj /Span<>> BDC ( )Tj EMC (\024\031\013\205\211\025\031 \016\021\026\021\025\002 \n)Tj /Span<>> BDC ( )Tj EMC (\013\n\023\n\032\031\013\024\026\023\022\021\n\003 \032\026\013\031 \033\ \205\024\031\003 \n\005\n\005\211\031\021\025\002 \t\205\211\031\t\024\027\ \205\007\211\031\017 \025\021\f\n\032\003\026\203\025\025 \033\n)Tj /Span<>> BDC ( )Tj EMC (\026\021\026\023\025)Tj 0 Tw (-)Tj 0.104 Tw 0 -1.111 TD (\016\025\032\205\031\003\n\017 \024\031\003\031 \025)Tj /Span<>> BDC ( )Tj EMC (\027\020\002\027\023\031\021\025\002 \005\205\030\205\211\025\004 \021\026\ \033\032\026\027\023\031\021\025\017 \033\031\032\t\033\031\013\024\025\027\ \021\020\004 \025\t\t\023\031\030\n\027\026\021\025\017, \027\013\023\007\ \006\026\002 \032\n\023\022 \033\026\032\026\024\202\n\032)Tj 0 Tw (-)Tj 0.026 Tw 0 -1.111 TD [(\003\n\021-\032\n\030\t\024\027\031\021\021\n\202\n )0.6(\033\032\n\024\031\025\021\026 )0.5(\027)]TJ /Span<>> BDC ( )Tj EMC [(\013\n\023\n\032\031\013\024\026\023\022\021\n\003 )0.6(\n\021\013\n\202\031\021\031\016\031, )0.5(\t\025\202\021\026\023\022\021\020\004 \033\205\024\002\004, \205\006\026\ \t\024\027\205\007\211\025\004 \027)]TJ /Span<>> BDC ( )Tj EMC (\003\025\024\n\202\031\021\021\n\003 )Tj 0.077 Tw T* (\030\031\017\t\024\027\025\025 \r\024\n\202\n \005\031\023\013\026 \021\026\ )Tj /Span<>> BDC ( )Tj EMC (\n\033\205\004\n\023\031\027\020\031 \013\023\031\024\013\025, \031\202\n\ \027\023\025\002\021\025\031 \021\026)Tj /Span<>> BDC ( )Tj EMC (\n\033\205\004\n\023\031\027\020\017 \026\021\202\025\n\202\031\021\031\016\ . \216)Tj /Span<>> BDC ( )Tj EMC (\n\005\016\n\032\031 \033\032\025\027\031\030\031\021\020 )Tj 0.063 Tw T* [(\032\031\016\205\023\022\024\026\024\020 )0.6(\t\n\027\032\031\003\031\021\021\020\004 )0.6(\025\t\t\023\031\030\n\027\026\021\025\017 )0.6(\n\005 )0.6(\205\006\026\t\024\025\025 )0.6(\220\210\032 )0.6(\027)]TJ /Span<>> BDC ( )Tj EMC 25.667 0 Td [(\f\n\032\003\025\032\n\027\026\021\025\025 )0.5(\004\025\003\025\n\032\031\016\025\t\024\031\021\024\021\n\t\024\025 )0.6(\013\023\031\024\n\013 )]TJ 0.149 Tw -25.667 -1.111 Td (\013\n\023\n\032\031\013\024\026\023\022\021\n\202\n \032\026\013\026 \025\ )Tj /Span<>> BDC ( )Tj EMC (\031\202\n \027\023\025\002\021\025\025 \021\026)Tj /Span<>> BDC ( )Tj EMC (\003\n\030\205\023\002\203\025\007 \033\032\n\202\032\026\003\003\020 \r\ \033\025\024\031\023\025\026\023\022\021\n-\003\031\016\031\021\004\025\003\ \026\023\022\021\n\202\n \033\031\032\031\004\n\030\026 )Tj 0.076 Tw T* (\025)Tj /Span<>> BDC ( )Tj EMC (\030\032\205\202\025\031 \t\n\005\020\024\025\002, \t\027\002\016\026\021\ \021\020\031 \t)Tj /Span<>> BDC ( )Tj EMC (\025\021\027\026\016\025\031\017 \n\033\205\004\n\023\025. \032\031\030\ \t\024\026\027\023\031\021\020 \f\026\013\024\020, \t\027\025\030\031\024\ \031\023\022\t\024\027\205\007\211\025\031 \n\005 \205\006\026\t\024\025\ \025 )Tj 0.07 Tw T* (\220\210\032 \027)Tj /Span<>> BDC ( )Tj EMC (\033\032\025\n\005\032\031\024\031\021\025\025 \013\023\031\024\013\026\003\ \025 \013\n\023\n\032\031\013\024\026\023\022\021\n\202\n \032\026\013\026\ \026\202\032\031\t\t\025\027\021\n\202\n \f\031\021\n\024\025\033\026, \ \025)Tj /Span<>> BDC ( )Tj EMC (\n\033\025\t\026\021\020 \003\n\023\031\013\205\023\002\032\021\020\031 \ )Tj 0.062 Tw T* (\003\031\004\026\021\025\016\003\020, \016\026\030\031\017\t\024\027\n\027\ \026\021\021\020\031 \027)Tj /Span<>> BDC ( )Tj EMC (\r\024\025\004 \033\032\n\203\031\t\t\026\004. \255\024\003\031\006\026\031\ \024\t\002 \027\t\031 \027\n\016\032\026\t\024\026\007\211\025\017 \025\021\ \024\031\032\031\t \013)Tj /Span<>> BDC ( )Tj EMC (\025\t\033\n\023\022\016\n\027\026\021\025\007 )Tj 0.034 Tw T* (\r\f\f\031\013\024\n\027 \r\024\n\202\n \205\021\025\013\026\023\022\021\ \n\202\n \027\n \003\021\n\202\025\004 \n\024\021\n\001\031\021\025\002\004\ \033\032\n\024\031\025\021\026 \027)Tj /Span<>> BDC ( )Tj EMC (\024\031\032\026\033\031\027\024\025\006\031\t\013\025\004 \203\031\023\002\ \004, \006\024\n \n\033\032\031\030\031\023\002\031\024 )Tj 0.146 Tw 0 -1.111 TD (\026\013\024\025\027\021\205\007 \032\026\016\032\026\005\n\024\013\205 \ \f\026\032\003\026\013\n\023\n\202\025\006\031\t\013\025\004 \t\205\005\t\ \024\026\021\203\025\017 \021\026)Tj /Span<>> BDC ( )Tj EMC (\n\t\021\n\027\031 \026\021\026\023\n\202\n\027 \r\024\n\202\n \005\031\023\ \013\026. \222\n\021\031\006\021\n\017 \203\031\023\022\007 )Tj 0.03 Tw 0 -1.111 TD [(\002\027\023\002\031\024\t\002 )0.6(\033\032\n\030\027\025\204\031\021\025\031 )0.6(\032\026\016\032\026\005\n\024\013\025 )0.5(\r\f\f\031\013\024\025\027\021\020\004 )0.6(\024\031\032\026\033\031\027\024\025\006\031\t\013\025\004 )0.6(\t\024\032\026\024\031\202\025\017, )0.5(\013\n\024\n\032\020\031 )0.5(\003\n\202\205\024 )0.5(\205\023\205\006\001\025\024\022 )]TJ 0.023 Tw T* (\032\031\016\205\023\022\024\026\024\020 \023\031\006\031\021\025\002 \013\ \n\023\n\032\031\013\024\026\023\022\021\n\202\n \032\026\013\026 \205)Tj /Span<>> BDC ( )Tj EMC (\033\026\203\025\031\021\024\n\027.)Tj /T1_2 1 Tf 0.01 Tc 0.018 Tw 8 0 0 8 70.906 366.3797 Tm [(\037\036\035\034\033\032\031\033)5( \030\036\027\032\026:)]TJ /T1_0 1 Tf 0 Tc 0.023 Tw 8.493 0 Td ( \013\n\023\n\032\031\013\024\026\023\022\021\020\017 \032\026\013, \033\ \026\032\026\024\202\n\032\003\n\021-\032\n\030\t\024\027\031\021\021\020\ \017 \033\032\n\024\031\025\021)Tj /T1_2 1 Tf 0.01 Tc 0.018 Tw -8.493 -1.909 Td [(\037\027\025\024\036\023\037\022)5( \023\025\022\033\021\033\030\027\032:)]TJ /T1_0 1 Tf 0 Tc 0.023 Tw 10.401 0 Td ( \026\027\024\n\032\020 \016\026\002\027\023\002\007\024 \n\005 \n\024\t\ \205\024\t\024\027\025\025 \013\n\021\f\023\025\013\024\n\027 \025\021\024\ \031\032\031\t\026)Tj /T1_2 1 Tf 0.022 Tc -0.04 Tw -10.401 -2.617 Td [(\020\036\017)4.6( \016\023\022\023\021\027\032\026\025\023\017:)]TJ /T1_3 1 Tf 0.012 Tc -0.035 Tw 8.958 0 Td ( \025\031\030\026\027\024\r)Tj /Span<>> BDC ( )Tj EMC (\202.\203., \212\031\030\035\036\001\021\036\030)Tj /Span<>> BDC ( )Tj EMC (\200.\204., \207\t\022\024\r)Tj /Span<>> BDC ( )Tj EMC (\204.\222. \025\024\035\024\030\036\022\021\026\035\034\027\t\005 \030\026\ \022, \026\f\f\024\006\017\017\030\024\r\026\027\027\t\005 \f)Tj /Span<>> BDC ( )Tj EMC [(\023\026\030\026\021\020\024\030\n\024\027-\030\024\007\f\021\r\036\027\027\ \t\n)12( )]TJ 0.003 Tc -8.963 -1.2 Td (\023\030\024\021\036\017\027\024\n \(\024\002\024\030 \035\017\021\036\030\ \026\021\031\030\t\). )Tj /T1_0 1 Tf -0.003 Tw (\222\n\023\n\033\032\n\013\024\n\023\n\202\025\002.)Tj /T1_3 1 Tf -0.035 Tw ( 2024; \021.)Tj /Span<>> BDC ( )Tj EMC (23, \225)Tj /Span<>> BDC ( )Tj EMC (1, \f.)Tj /Span<>> BDC ( )Tj EMC (162\226171. https://doi.org/10.33878/2073-7556-2024-23-1-162-171)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0 Tc 0.023 Tw 18 0 0 18 132.8578 288.2333 Tm [(Color)31(ectal cancer associated with par)21.1(ath)31(yr)20(oid )]TJ 2.515 -1.167 Td [(h)11(ormone)-52(-r)31.1(elated pr)20(otein \(r)31(e)11(vie)11(w\))]TJ 0 0 0 1 k /GS1 gs 0 Tw 14 0 0 14 70.8661 242.7293 Tm [(Anatoliy\022)-23.2(N.\022)-23.3(K)31(ur)20(z)15(anov)]TJ 8.162 0 0 8.162 192.5046 247.3913 Tm (1)Tj 0.023 Tw 14 0 0 14 197.1405 242.7293 Tm [(, Vladimir\022)-23.2(M.\022)-23.3(Durleshter)]TJ -0.069 Tc 0.069 Tw 8.162 0 0 8.162 331.8019 247.3913 Tm [(1,)-69(3)]TJ 0 Tc 0.023 Tw 14 0 0 14 343.1225 242.7293 Tm [(, Mikhail\022)-23.2(I.\022)-23.3(Byk)11(ov)]TJ -0.069 Tc 0.069 Tw 8.162 0 0 8.162 441.0629 247.3913 Tm [(1,)-69(2)]TJ 0 Tc 0 Tw 5.83 0 0 5.83 70.8661 228.3901 Tm (1)Tj 0.023 Tw 10 0 0 10 74.1775 225.0601 Tm [(K)31(uban State Medical Univ)12.1(er)20(sit)-20(y of th)11.1(e Russian Health Ministr)-30.9(y \(Sedina st., 4, Kr)21.1(asnodar)52(, 350063, Russia\))]TJ 0 Tw ( )Tj 5.83 0 0 5.83 70.8661 216.3901 Tm (2)Tj 0.023 Tw 10 0 0 10 74.1775 213.0601 Tm [(Ochapov)10(sky Regional Clinical Hospital No. 1 of th)11.1(e Health Ministr)-31(y of th)11(e Kr)21(asnodar Region \(1st May st., 1)112(6)58(7)127(, )]TJ -0.331 -1.2 Td [(bld.\022)-23.3(1)69(, Kr)21(asnodar)52(, 350086, Russia\))]TJ 0 Tw ( )Tj 5.83 0 0 5.83 70.8661 192.3902 Tm (3)Tj 0.023 Tw 10 0 0 10 74.1775 189.0602 Tm [(Regional Clinical Hospital no. 2 of th)11(e Health Ministr)-30.9(y of th)11(e Kr)21(asnodar Region \(Kr)21.1(asnih P)20(ar)-20(tisan st., 6/2, )]TJ -0.331 -1.2 Td [(Kr)21(asnodar)52.1(, 3500)87(1)125(2)138(1)69(, Russia\))]TJ /T1_0 1 Tf 0.036 Tw 9 0 0 9 119.0551 158.5563 Tm [(P)18(arath)12(yroid hor)-14(mone-related p)45.9(ro)13(tein \(PTHrP\) is associated with v)16(ar)-36.9(ious cancer types. This is the f)-43(irst revie)10(w in the )]TJ 0.085 Tw T* [(R)22(ussian, dev)13(o)13(ted to this topic, and it is aimed to contr)-36.9(ibute to the cur)-16(rent know)10.1(ledg)12(e about colorectal cancer)61(, by )]TJ 0.054 Tw T* [(means of summar)-36.9(izing all known infor)-14(mation on the topic and identifying future directions for adv)16(anced research )]TJ 0.003 Tw T* [(including on the role of parath)12(yroid hor)-13.9(mone-related p)46(ro)13(tein in colorectal oncog)12(enesis, signal channels that par)-39.9(tici)]TJ 0 Tw (-)Tj 0.014 Tw T* [(pate in mitog)12.1(enic action of the p)46(ro)13(tein on cancer cells, its ef)-40(fect on tumor angiog)12(enesis. The revie)10(w includes results )]TJ 0.042 Tw 0 -1.111 TD [(of moder)-13.9(n research in)11(v)13(olv)13(ement of PTHrP in the for)-14(mation of chemoresistance of colorectal cancer cells, as w)12(ell as )]TJ 0.005 Tw 0 -1.111 TD [(its )0.5(inf)-22(luence )0.6(on )0.5(the )0.5(modulation )0.6(of )0.5(the )0.5(epithelial-mesench)12.2(ymal )0.5(transition )0.5(p)46(rog)14(ram )0.5(and )0.5(o)12.9(ther )0.5(ev)13(ents, )0.5(associated )0.5(with )]TJ 0.004 Tw T* [(tumor in)11(v)16(asion. The revie)10(w p)46(resents infor)-13.9(mation p)46(roving that PTHrP is related to colorectal cancer cells becoming of )]TJ ET 1 0.68 0 0.12 k /GS0 gs q 1 0 0 1 70.8661 550.1533 cm 0 0 m 0 0 l 0 -11.339 l 42.52 -11.339 l 42.52 0 l h f Q BT 0 0 0 0 k /T1_2 1 Tf 0 Tw 9 0 0 9 76.0071 541.226 Tm (\021\033\r\035\f\033)Tj ET 1 0.68 0 0.12 k q 1 0 0 1 70.8661 167.0605 cm 0 0 m 0 0 l 0 -11.339 l 42.52 -11.339 l 42.52 0 l h f Q BT 0 0 0 0 k /T1_2 1 Tf 9 0 0 9 73.5728 158.1333 Tm (ABSTRACT)Tj 1 0.68 0 0.12 k /T1_1 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\214)10(\211\036\033 \035\030\032\t\033)30(\b)42(\032)-21(\240\033\233)]TJ 57.136 0 Td (REVIEW)Tj -57.136 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 23, \023\0221)69(, 202)69(4)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 23, \023\0221)69(, 202)69(4)]TJ /T1_4 1 Tf 25 0 0 25 20.7776 56.0378 Tm (162)Tj ET q 0 g 0 G 0 j 0 J /Fm1 Do Q 0 0 0 0 k 396.85 725.67 59.155 11.338 re f /PlacedPDF /MC0 BDC q 397.481 736.808 m 397.242 736.808 397.049 736.616 397.049 736.376 c 397.049 736.376 l 397.049 726.285 l 397.049 726.045 397.242 725.853 397.481 725.853 c 397.481 725.853 l 455.382 725.853 l 455.62 725.853 455.815 726.045 455.815 726.285 c 455.815 726.285 l 455.815 736.376 l 455.815 736.616 455.62 736.808 455.382 736.808 c 455.382 736.808 l h W n q 0 g -0.0000005 -10.9560913 -10.9560913 0.0000005 426.4320445 736.8086309 cm BX /Sh0 sh EX Q Q q 396.85 725.67 59.155 11.337 re W n 0 0 0 0.84 k q 1 0 0 1 413.5634 732.4249 cm 0 0 m -0.025 0.1 -0.063 0.196 -0.112 0.287 c -0.157 0.374 -0.218 0.451 -0.292 0.515 c -0.37 0.582 -0.46 0.632 -0.558 0.664 c -0.669 0.701 -0.786 0.719 -0.903 0.717 c -1.076 0.722 -1.247 0.681 -1.4 0.6 c -1.536 0.526 -1.652 0.42 -1.74 0.292 c -1.83 0.158 -1.895 0.008 -1.934 -0.149 c -2.018 -0.48 -2.018 -0.827 -1.934 -1.158 c -1.896 -1.316 -1.83 -1.466 -1.74 -1.602 c -1.653 -1.731 -1.536 -1.837 -1.4 -1.912 c -1.247 -1.993 -1.076 -2.033 -0.903 -2.029 c -0.774 -2.032 -0.647 -2.006 -0.528 -1.955 c -0.427 -1.906 -0.337 -1.837 -0.263 -1.753 c -0.185 -1.665 -0.124 -1.563 -0.082 -1.453 c -0.034 -1.338 0 -1.218 0.019 -1.094 c 0.635 -1.094 l 0.624 -1.297 0.578 -1.497 0.497 -1.684 c 0.421 -1.857 0.312 -2.015 0.175 -2.146 c 0.039 -2.277 -0.123 -2.379 -0.3 -2.446 c -0.492 -2.519 -0.695 -2.555 -0.9 -2.552 c -1.15 -2.557 -1.397 -2.506 -1.625 -2.404 c -1.829 -2.307 -2.01 -2.169 -2.157 -1.997 c -2.308 -1.821 -2.423 -1.617 -2.497 -1.397 c -2.655 -0.924 -2.655 -0.412 -2.497 0.061 c -2.423 0.281 -2.307 0.485 -2.157 0.661 c -2.01 0.833 -1.829 0.973 -1.625 1.07 c -1.398 1.174 -1.15 1.226 -0.9 1.222 c -0.707 1.223 -0.515 1.196 -0.329 1.14 c -0.159 1.088 0.001 1.006 0.144 0.898 c 0.278 0.793 0.39 0.662 0.473 0.513 c 0.562 0.349 0.615 0.167 0.629 -0.019 c 0 -0.019 l 0 0 l f Q q 1 0 0 1 414.6923 733.5723 cm 0 0 m 0.584 0 l 0.584 -1.328 l 0.662 -1.204 0.771 -1.103 0.9 -1.033 c 1.046 -0.951 1.213 -0.91 1.381 -0.914 c 1.627 -0.9 1.869 -0.979 2.058 -1.137 c 2.234 -1.312 2.325 -1.556 2.305 -1.803 c 2.305 -3.596 l 1.716 -3.596 l 1.716 -1.976 l 1.724 -1.817 1.678 -1.66 1.585 -1.53 c 1.486 -1.43 1.347 -1.379 1.206 -1.392 c 1.114 -1.39 1.024 -1.408 0.94 -1.445 c 0.865 -1.479 0.798 -1.529 0.744 -1.591 c 0.687 -1.656 0.645 -1.73 0.616 -1.812 c 0.586 -1.896 0.571 -1.986 0.571 -2.077 c 0.571 -3.615 l 0 -3.615 l 0 0 l f Q q 1 0 0 1 418.0385 731.1235 cm 0 0 m 0 -0.099 0.014 -0.198 0.043 -0.292 c 0.069 -0.382 0.112 -0.466 0.17 -0.54 c 0.229 -0.611 0.304 -0.669 0.388 -0.709 c 0.486 -0.754 0.594 -0.776 0.702 -0.773 c 0.845 -0.78 0.987 -0.742 1.108 -0.664 c 1.217 -0.582 1.296 -0.468 1.336 -0.337 c 1.881 -0.337 l 1.827 -0.603 1.675 -0.838 1.456 -0.996 c 1.35 -1.073 1.231 -1.131 1.105 -1.169 c 0.971 -1.208 0.831 -1.229 0.691 -1.227 c 0.509 -1.227 0.328 -1.191 0.16 -1.121 c 0.007 -1.063 -0.13 -0.972 -0.244 -0.855 c -0.356 -0.73 -0.44 -0.583 -0.491 -0.422 c -0.548 -0.243 -0.576 -0.056 -0.574 0.133 c -0.575 0.313 -0.545 0.493 -0.486 0.664 c -0.426 0.826 -0.335 0.974 -0.22 1.102 c 0.004 1.375 0.338 1.534 0.691 1.535 c 0.883 1.539 1.072 1.495 1.243 1.408 c 1.402 1.326 1.541 1.209 1.649 1.067 c 1.759 0.922 1.838 0.757 1.883 0.582 c 1.932 0.396 1.945 0.203 1.92 0.013 c 0 0.013 l 0 0 l 1.342 0.377 m 1.335 0.468 1.315 0.557 1.283 0.643 c 1.253 0.724 1.209 0.798 1.153 0.863 c 1.097 0.922 1.03 0.97 0.957 1.004 c 0.874 1.043 0.783 1.063 0.691 1.062 c 0.6 1.062 0.509 1.044 0.425 1.009 c 0.345 0.976 0.273 0.926 0.213 0.863 c 0.153 0.799 0.105 0.724 0.072 0.643 c 0.037 0.559 0.017 0.468 0.014 0.377 c 1.355 0.377 l h f Q q 1 0 0 1 422.1581 731.7051 cm 0 0 m -0.012 0.144 -0.082 0.276 -0.194 0.366 c -0.31 0.452 -0.451 0.495 -0.595 0.489 c -0.675 0.488 -0.755 0.476 -0.831 0.452 c -0.918 0.424 -0.998 0.375 -1.062 0.311 c -1.142 0.229 -1.202 0.131 -1.24 0.024 c -1.29 -0.132 -1.312 -0.296 -1.304 -0.459 c -1.304 -0.569 -1.292 -0.677 -1.267 -0.784 c -1.244 -0.885 -1.202 -0.983 -1.145 -1.07 c -1.09 -1.154 -1.016 -1.224 -0.93 -1.275 c -0.833 -1.33 -0.722 -1.356 -0.611 -1.352 c -0.457 -1.357 -0.307 -1.301 -0.194 -1.195 c -0.078 -1.077 -0.005 -0.922 0.011 -0.757 c 0.587 -0.757 l 0.556 -1.055 0.419 -1.332 0.202 -1.538 c -0.022 -1.721 -0.306 -1.815 -0.595 -1.803 c -0.777 -1.806 -0.958 -1.771 -1.126 -1.7 c -1.293 -1.642 -1.445 -1.547 -1.57 -1.421 c -1.68 -1.297 -1.763 -1.151 -1.814 -0.993 c -1.87 -0.822 -1.898 -0.643 -1.896 -0.462 c -1.898 -0.276 -1.871 -0.091 -1.817 0.087 c -1.766 0.252 -1.682 0.405 -1.57 0.537 c -1.459 0.664 -1.323 0.766 -1.168 0.834 c -0.991 0.914 -0.798 0.955 -0.603 0.954 c -0.457 0.954 -0.311 0.935 -0.17 0.895 c -0.039 0.858 0.084 0.799 0.194 0.72 c 0.302 0.643 0.393 0.543 0.459 0.428 c 0.531 0.298 0.572 0.155 0.582 0.008 c 0 0.008 l 0 0 l f Q q 1 0 0 1 423.2177 733.5723 cm 0 0 m 0.577 0 l 0.577 -2.048 l 1.615 -0.985 l 2.322 -0.985 l 1.323 -1.944 l 2.417 -3.604 l 1.716 -3.604 l 0.919 -2.337 l 0.577 -2.669 l 0.577 -3.604 l 0 -3.604 l h f Q q 1 0 0 1 427.0585 732.5762 cm 0 0 m 0.436 0 l 0.436 0.218 l 0.429 0.352 0.448 0.486 0.488 0.614 c 0.521 0.705 0.577 0.786 0.651 0.85 c 0.717 0.905 0.795 0.943 0.879 0.961 c 0.966 0.979 1.056 0.988 1.145 0.988 c 1.28 0.993 1.416 0.981 1.548 0.954 c 1.548 0.505 l 1.509 0.516 1.469 0.523 1.429 0.528 c 1.379 0.532 1.33 0.532 1.28 0.528 c 1.209 0.53 1.14 0.511 1.081 0.473 c 1.019 0.419 0.987 0.337 0.999 0.255 c 0.999 -0.011 l 1.498 -0.011 l 1.498 -0.441 l 1.009 -0.441 l 1.009 -2.622 l 0.436 -2.622 l 0.436 -0.428 l 0.005 -0.428 l 0.005 0 l 0 0 l f Q q 1 0 0 1 430.1 729.8965 cm 0 0 m -0.191 -0.003 -0.381 0.032 -0.559 0.104 c -0.715 0.167 -0.856 0.264 -0.972 0.388 c -1.091 0.512 -1.181 0.659 -1.238 0.82 c -1.356 1.18 -1.356 1.567 -1.238 1.925 c -1.181 2.087 -1.091 2.234 -0.972 2.358 c -0.856 2.481 -0.715 2.578 -0.559 2.643 c -0.199 2.78 0.198 2.78 0.558 2.643 c 0.714 2.578 0.855 2.481 0.972 2.358 c 1.09 2.234 1.181 2.087 1.237 1.925 c 1.355 1.567 1.355 1.18 1.237 0.82 c 1.181 0.659 1.09 0.512 0.972 0.388 c 0.855 0.266 0.713 0.169 0.558 0.106 c 0.38 0.034 0.191 -0.002 0 0 c 0 0.454 m 0.115 0.451 0.23 0.479 0.332 0.534 c 0.424 0.586 0.502 0.659 0.562 0.746 c 0.624 0.836 0.669 0.936 0.695 1.041 c 0.752 1.26 0.752 1.491 0.695 1.71 c 0.669 1.816 0.625 1.916 0.562 2.005 c 0.502 2.091 0.423 2.163 0.332 2.215 c 0.123 2.323 -0.126 2.323 -0.335 2.215 c -0.427 2.163 -0.505 2.091 -0.566 2.005 c -0.628 1.916 -0.673 1.816 -0.699 1.71 c -0.756 1.491 -0.756 1.26 -0.699 1.041 c -0.672 0.936 -0.627 0.836 -0.566 0.746 c -0.506 0.659 -0.427 0.586 -0.335 0.534 c -0.232 0.478 -0.117 0.451 0 0.454 c f Q q 1 0 0 1 431.8979 732.5762 cm 0 0 m 0.531 0 l 0.531 -0.505 l 0.55 -0.43 0.583 -0.359 0.629 -0.297 c 0.681 -0.229 0.74 -0.167 0.807 -0.114 c 0.877 -0.059 0.956 -0.014 1.039 0.019 c 1.123 0.053 1.213 0.07 1.304 0.069 c 1.52 0.069 l 1.52 -0.486 l 1.395 -0.467 l 1.269 -0.467 l 1.178 -0.468 1.087 -0.488 1.004 -0.526 c 0.917 -0.565 0.839 -0.625 0.778 -0.699 c 0.716 -0.783 0.669 -0.878 0.643 -0.98 c 0.604 -1.104 0.584 -1.233 0.586 -1.362 c 0.586 -2.603 l 0.01 -2.603 l 0.01 0 l 0 0 l f Q q 1 0 0 1 437.3666 729.9683 cm 0 0 m -0.577 0 l -0.577 0.364 l -0.649 0.23 -0.759 0.121 -0.893 0.047 c -1.022 -0.029 -1.169 -0.07 -1.32 -0.072 c -1.595 -0.095 -1.866 0.002 -2.064 0.194 c -2.234 0.413 -2.316 0.687 -2.295 0.964 c -2.295 2.608 l -1.719 2.608 l -1.719 1.014 l -1.735 0.843 -1.689 0.67 -1.588 0.531 c -1.492 0.433 -1.357 0.382 -1.219 0.39 c -1.116 0.387 -1.012 0.406 -0.917 0.446 c -0.84 0.479 -0.772 0.531 -0.72 0.595 c -0.667 0.661 -0.63 0.738 -0.611 0.82 c -0.588 0.911 -0.577 1.003 -0.577 1.097 c -0.577 2.611 l 0 2.611 l 0 0 l f Q q 1 0 0 1 437.9877 732.5762 cm 0 0 m 0.545 0 l 0.545 -0.353 l 0.617 -0.209 0.736 -0.094 0.882 -0.026 c 1.03 0.04 1.19 0.073 1.352 0.072 c 1.535 0.075 1.717 0.038 1.883 -0.037 c 2.031 -0.106 2.161 -0.208 2.263 -0.334 c 2.366 -0.465 2.442 -0.615 2.489 -0.775 c 2.54 -0.948 2.566 -1.127 2.566 -1.307 c 2.566 -1.479 2.542 -1.651 2.497 -1.817 c 2.455 -1.973 2.385 -2.121 2.29 -2.252 c 2.099 -2.522 1.789 -2.682 1.458 -2.68 c 1.369 -2.681 1.28 -2.674 1.193 -2.659 c 1.11 -2.644 1.028 -2.618 0.951 -2.584 c 0.875 -2.552 0.802 -2.509 0.736 -2.457 c 0.671 -2.406 0.615 -2.343 0.571 -2.273 c 0.571 -3.575 l -0.005 -3.575 l -0.005 0 l 0 0 l 2.008 -1.307 m 2.008 -1.191 1.993 -1.076 1.963 -0.964 c 1.936 -0.859 1.89 -0.759 1.828 -0.669 c 1.768 -0.584 1.69 -0.514 1.599 -0.462 c 1.503 -0.409 1.395 -0.382 1.286 -0.385 c 1.072 -0.372 0.867 -0.467 0.738 -0.638 c 0.607 -0.836 0.543 -1.072 0.555 -1.31 c 0.554 -1.433 0.57 -1.557 0.603 -1.676 c 0.631 -1.781 0.68 -1.879 0.747 -1.965 c 0.809 -2.044 0.886 -2.109 0.975 -2.157 c 1.071 -2.206 1.178 -2.23 1.286 -2.229 c 1.401 -2.232 1.517 -2.205 1.618 -2.148 c 1.708 -2.096 1.785 -2.025 1.843 -1.939 c 1.903 -1.85 1.945 -1.751 1.968 -1.646 c 1.995 -1.535 2.008 -1.421 2.008 -1.307 c f Q q 1 0 0 1 443.5127 729.9683 cm 0 0 m -0.545 0 l -0.545 0.353 l -0.616 0.211 -0.734 0.099 -0.879 0.034 c -1.027 -0.031 -1.187 -0.065 -1.349 -0.064 c -1.532 -0.067 -1.714 -0.03 -1.88 0.045 c -2.028 0.113 -2.158 0.214 -2.26 0.34 c -2.364 0.47 -2.441 0.62 -2.486 0.781 c -2.538 0.958 -2.564 1.143 -2.563 1.328 c -2.568 1.536 -2.536 1.742 -2.468 1.938 c -2.41 2.097 -2.319 2.242 -2.202 2.364 c -2.101 2.471 -1.977 2.555 -1.838 2.608 c -1.705 2.659 -1.563 2.685 -1.421 2.685 c -1.338 2.685 -1.256 2.678 -1.174 2.664 c -1.091 2.648 -1.01 2.624 -0.932 2.589 c -0.855 2.556 -0.783 2.514 -0.717 2.462 c -0.652 2.411 -0.597 2.349 -0.553 2.279 c -0.553 3.606 l 0.024 3.606 l 0.024 0 l 0 0 l -2.008 1.277 m -2.009 1.166 -1.994 1.056 -1.965 0.948 c -1.939 0.845 -1.896 0.748 -1.835 0.661 c -1.777 0.578 -1.699 0.508 -1.61 0.459 c -1.404 0.355 -1.162 0.355 -0.956 0.459 c -0.866 0.512 -0.789 0.585 -0.73 0.671 c -0.671 0.762 -0.626 0.862 -0.6 0.966 c -0.572 1.076 -0.558 1.188 -0.558 1.301 c -0.543 1.542 -0.612 1.781 -0.751 1.979 c -0.88 2.14 -1.078 2.229 -1.283 2.22 c -1.402 2.224 -1.52 2.196 -1.623 2.138 c -1.714 2.083 -1.793 2.009 -1.852 1.92 c -1.911 1.828 -1.954 1.725 -1.977 1.617 c -1.999 1.505 -2.01 1.392 -2.008 1.277 c f Q q 1 0 0 1 446.3252 730.5499 cm 0 0 m -0.004 -0.052 0.005 -0.104 0.026 -0.151 c 0.052 -0.185 0.094 -0.202 0.136 -0.197 c 0.197 -0.197 l 0.223 -0.2 0.25 -0.2 0.276 -0.197 c 0.276 -0.595 l 0.199 -0.619 l 0.101 -0.64 l 0 -0.656 l -0.085 -0.656 l -0.187 -0.66 -0.288 -0.635 -0.377 -0.584 c -0.461 -0.528 -0.516 -0.437 -0.528 -0.337 c -0.648 -0.451 -0.792 -0.534 -0.951 -0.579 c -1.106 -0.628 -1.269 -0.654 -1.432 -0.656 c -1.546 -0.657 -1.659 -0.641 -1.769 -0.608 c -1.872 -0.579 -1.967 -0.531 -2.053 -0.468 c -2.136 -0.405 -2.203 -0.324 -2.25 -0.231 c -2.3 -0.127 -2.326 -0.012 -2.324 0.104 c -2.33 0.24 -2.299 0.375 -2.236 0.497 c -2.181 0.594 -2.101 0.675 -2.005 0.733 c -1.905 0.791 -1.795 0.833 -1.681 0.855 c -1.562 0.88 -1.442 0.899 -1.32 0.914 c -1.222 0.933 -1.123 0.947 -1.022 0.956 c -0.938 0.963 -0.855 0.977 -0.773 0.999 c -0.708 1.014 -0.649 1.046 -0.6 1.092 c -0.556 1.144 -0.533 1.211 -0.536 1.28 c -0.534 1.344 -0.553 1.408 -0.59 1.46 c -0.624 1.507 -0.668 1.544 -0.72 1.569 c -0.775 1.596 -0.834 1.613 -0.895 1.62 c -0.955 1.624 -1.016 1.624 -1.076 1.62 c -1.215 1.625 -1.354 1.591 -1.474 1.519 c -1.581 1.45 -1.647 1.333 -1.652 1.206 c -2.231 1.206 l -2.227 1.354 -2.185 1.498 -2.108 1.625 c -2.041 1.733 -1.951 1.824 -1.843 1.891 c -1.729 1.96 -1.603 2.007 -1.472 2.032 c -1.329 2.072 -1.183 2.098 -1.036 2.109 c -0.908 2.109 -0.781 2.096 -0.656 2.069 c -0.538 2.044 -0.425 2 -0.321 1.939 c -0.225 1.88 -0.143 1.8 -0.083 1.705 c -0.02 1.599 0.012 1.478 0.008 1.354 c 0.008 0.013 l 0 0 l -0.576 0.728 m -0.674 0.667 -0.785 0.631 -0.9 0.624 c -1.028 0.612 -1.155 0.594 -1.283 0.571 c -1.343 0.561 -1.402 0.547 -1.46 0.528 c -1.515 0.511 -1.566 0.485 -1.612 0.451 c -1.657 0.419 -1.692 0.376 -1.716 0.327 c -1.742 0.267 -1.755 0.203 -1.753 0.138 c -1.755 0.079 -1.735 0.021 -1.697 -0.024 c -1.661 -0.067 -1.615 -0.103 -1.564 -0.127 c -1.509 -0.154 -1.451 -0.171 -1.392 -0.181 c -1.335 -0.19 -1.278 -0.196 -1.222 -0.197 c -1.152 -0.196 -1.083 -0.188 -1.015 -0.173 c -0.94 -0.156 -0.87 -0.127 -0.805 -0.088 c -0.74 -0.048 -0.684 0.004 -0.64 0.066 c -0.594 0.134 -0.571 0.215 -0.574 0.297 c -0.574 0.725 l h f Q q 1 0 0 1 446.6836 732.5762 cm 0 0 m 0.434 0 l 0.434 0.784 l 0.996 0.784 l 0.996 0 l 1.527 0 l 1.527 -0.43 l 0.996 -0.43 l 0.996 -1.822 l 0.993 -1.874 0.993 -1.927 0.996 -1.979 c 1 -2.018 1.011 -2.056 1.031 -2.09 c 1.05 -2.122 1.079 -2.146 1.113 -2.159 c 1.162 -2.177 1.213 -2.185 1.265 -2.183 c 1.387 -2.183 l 1.428 -2.181 1.469 -2.175 1.509 -2.165 c 1.509 -2.608 l 1.323 -2.629 l 1.261 -2.633 1.199 -2.633 1.137 -2.629 c 1.013 -2.633 0.89 -2.619 0.771 -2.587 c 0.688 -2.564 0.613 -2.52 0.553 -2.459 c 0.499 -2.4 0.462 -2.328 0.446 -2.25 c 0.427 -2.155 0.416 -2.059 0.415 -1.963 c 0.415 -0.428 l -0.019 -0.428 l -0.019 0 l 0 0 l f Q q 1 0 0 1 449.0742 731.1235 cm 0 0 m 0 -0.099 0.014 -0.198 0.042 -0.292 c 0.068 -0.382 0.112 -0.466 0.17 -0.54 c 0.229 -0.611 0.303 -0.669 0.388 -0.709 c 0.486 -0.754 0.593 -0.776 0.701 -0.773 c 0.845 -0.78 0.987 -0.742 1.107 -0.664 c 1.216 -0.582 1.296 -0.468 1.336 -0.337 c 1.88 -0.337 l 1.827 -0.603 1.674 -0.838 1.456 -0.996 c 1.349 -1.073 1.231 -1.131 1.105 -1.169 c 0.973 -1.208 0.836 -1.228 0.699 -1.227 c 0.512 -1.23 0.327 -1.196 0.154 -1.126 c 0.003 -1.066 -0.133 -0.973 -0.244 -0.855 c -0.356 -0.73 -0.44 -0.583 -0.491 -0.422 c -0.548 -0.243 -0.576 -0.056 -0.574 0.133 c -0.575 0.313 -0.546 0.493 -0.486 0.664 c -0.426 0.826 -0.336 0.974 -0.221 1.102 c 0.002 1.374 0.334 1.532 0.685 1.535 c 0.877 1.539 1.067 1.495 1.238 1.408 c 1.396 1.326 1.535 1.209 1.644 1.067 c 1.753 0.922 1.833 0.757 1.878 0.582 c 1.927 0.396 1.939 0.203 1.915 0.013 c -0.002 0.013 l 0 0 l 1.341 0.377 m 1.335 0.468 1.315 0.557 1.283 0.643 c 1.253 0.724 1.209 0.798 1.153 0.863 c 1.096 0.926 1.027 0.978 0.951 1.014 c 0.868 1.054 0.777 1.074 0.685 1.073 c 0.594 1.073 0.504 1.055 0.419 1.02 c 0.339 0.986 0.267 0.937 0.207 0.874 c 0.147 0.81 0.099 0.735 0.066 0.653 c 0.031 0.569 0.011 0.479 0.008 0.388 c 1.349 0.388 l h f Q q 1 0 0 1 451.8657 730.7994 cm 0 0 m 0.002 -0.142 0.073 -0.274 0.191 -0.353 c 0.312 -0.423 0.45 -0.458 0.59 -0.454 c 0.651 -0.458 0.711 -0.458 0.773 -0.454 c 0.839 -0.447 0.904 -0.43 0.967 -0.406 c 1.024 -0.385 1.075 -0.349 1.116 -0.303 c 1.155 -0.252 1.174 -0.189 1.168 -0.125 c 1.166 -0.057 1.138 0.008 1.089 0.056 c 1.033 0.107 0.967 0.146 0.895 0.17 c 0.809 0.201 0.72 0.226 0.629 0.245 c 0.329 0.33 l 0.224 0.352 0.121 0.38 0.019 0.415 c -0.076 0.446 -0.166 0.491 -0.247 0.55 c -0.327 0.608 -0.391 0.683 -0.436 0.771 c -0.486 0.873 -0.511 0.986 -0.507 1.1 c -0.512 1.226 -0.475 1.351 -0.404 1.456 c -0.333 1.551 -0.243 1.63 -0.138 1.687 c -0.028 1.747 0.092 1.788 0.215 1.809 c 0.337 1.832 0.462 1.843 0.587 1.843 c 0.716 1.844 0.845 1.83 0.972 1.801 c 1.09 1.774 1.202 1.727 1.304 1.663 c 1.404 1.598 1.488 1.513 1.551 1.413 c 1.621 1.3 1.663 1.173 1.676 1.041 c 1.076 1.041 l 1.059 1.155 0.989 1.253 0.887 1.307 c 0.78 1.355 0.665 1.38 0.547 1.378 c 0.5 1.381 0.452 1.381 0.403 1.378 c 0.35 1.373 0.298 1.36 0.247 1.341 c 0.2 1.325 0.157 1.297 0.122 1.262 c 0.087 1.224 0.069 1.174 0.071 1.124 c 0.069 1.058 0.096 0.995 0.146 0.951 c 0.202 0.903 0.267 0.866 0.337 0.842 c 0.424 0.811 0.512 0.786 0.603 0.768 c 0.917 0.701 l 1.021 0.678 1.124 0.65 1.224 0.616 c 1.319 0.584 1.409 0.539 1.49 0.481 c 1.662 0.359 1.762 0.16 1.755 -0.05 c 1.76 -0.189 1.723 -0.326 1.649 -0.443 c 1.582 -0.551 1.491 -0.642 1.384 -0.709 c 1.267 -0.778 1.14 -0.827 1.007 -0.855 c 0.873 -0.885 0.735 -0.9 0.598 -0.9 c 0.443 -0.902 0.29 -0.883 0.141 -0.845 c 0.01 -0.812 -0.114 -0.753 -0.223 -0.674 c -0.324 -0.601 -0.407 -0.504 -0.465 -0.393 c -0.527 -0.269 -0.559 -0.131 -0.558 0.008 c 0.019 0.008 l 0 0 l f Q 0.146 0.941 0.992 0.044 k q 1 0 0 1 401.2527 729.3892 cm 0 0 m 3.612 2.406 l 3.612 5.296 l 0 5.296 l h f Q 0 0.889 0.676 0 k q 1 0 0 1 404.865 729.3892 cm 0 0 m -3.612 2.406 l -3.612 5.296 l 0 5.296 l h f Q 0.694 0.076 0.209 0 k q 1 0 0 1 403.0589 735.3145 cm 0 0 m -2.2 0 -3.984 -1.784 -3.984 -3.984 c -3.984 -6.184 -2.2 -7.968 0 -7.968 c 2.2 -7.968 3.984 -6.184 3.984 -3.984 c 3.984 -1.784 2.2 0 0 0 c 0 -6.993 m -1.662 -6.993 -3.009 -5.646 -3.009 -3.984 c -3.009 -2.322 -1.662 -0.975 0 -0.975 c 1.662 -0.975 3.009 -2.322 3.009 -3.984 c 3.009 -5.646 1.662 -6.993 0 -6.993 c f Q 0 0.235 0.86 0 k q 1 0 0 1 405.2601 729.2803 cm 0 0 m -1.118 -1.208 -3.015 -1.281 -4.237 -0.159 c -5.159 0.688 -5.459 2.005 -4.999 3.156 c -5.833 3.687 l -6.736 1.681 -5.843 -0.679 -3.836 -1.582 c -2.218 -2.311 -0.312 -1.881 0.836 -0.528 c 0 0 l f Q 0 0 0 0.6 k q 1 0 0 1 397.4813 736.8087 cm 0 0 m -0.238 0 -0.432 -0.193 -0.432 -0.432 c -0.432 -10.524 l -0.432 -10.763 -0.238 -10.956 0 -10.956 c 57.901 -10.956 l 58.139 -10.956 58.333 -10.763 58.333 -10.524 c 58.333 -0.432 l 58.333 -0.193 58.139 0 57.901 0 c h 57.901 -11.155 m 0 -11.155 l -0.348 -11.155 -0.631 -10.872 -0.631 -10.524 c -0.631 -0.432 l -0.631 -0.084 -0.348 0.199 0 0.199 c 57.901 0.199 l 58.249 0.199 58.532 -0.084 58.532 -0.432 c 58.532 -10.524 l 58.532 -10.872 58.249 -11.155 57.901 -11.155 c f Q EMC Q endstream endobj 460 0 obj <> endobj 465 0 obj <>stream Adobe Illustrator CS6 (Windows) 2021-04-12T11:45:36+05:00 2021-06-02T10:28:09+05:00 2021-06-02T10:28:09+05:00 1 False False 20.868494 3.999928 Millimeters Cyan Magenta Yellow Black Default Swatch Group 0 C=0 M=24 Y=86 K=0 PROCESS 100.000000 CMYK 0.000000 23.504999 86.022697 0.000000 C=69 M=8 Y=21 K=0 PROCESS 100.000000 CMYK 69.369003 7.635600 20.892700 0.000000 C=0 M=89 Y=68 K=0 PROCESS 100.000000 CMYK 0.000000 88.946404 67.623398 0.000000 C=15 M=94 Y=99 K=4 PROCESS 100.000000 CMYK 14.578501 94.070297 99.160698 4.416000 C=0 M=0 Y=0 K=84 PROCESS 100.000000 CMYK 0.000000 0.000000 0.000000 84.000000 C=0 M=0 Y=0 K=35 PROCESS 100.000000 CMYK 0.000000 0.000000 0.000000 35.000000 C=0 M=0 Y=0 K=60 PROCESS 100.000000 CMYK 0.000000 0.000000 0.000000 60.000004 Document application/pdf proof:pdf xmp.did:804244B35A9BEB118A6FC3C256996E2F uuid:08e30110-bdb7-4606-97ca-63fb62cbcecc uuid:21079f76-f6d7-4329-b725-f2fb35af5114 uuid:722f8893-0b3c-4402-87fb-c713f1fa0e26 uuid:21079f76-f6d7-4329-b725-f2fb35af5114 uuid:21079f76-f6d7-4329-b725-f2fb35af5114 proof:pdf saved xmp.iid:804244B35A9BEB118A6FC3C256996E2F 2021-04-12T11:45:42+05:00 Adobe Illustrator CS6 (Windows) / endstream endobj 464 0 obj <>/Border[0 0 0]/H/N/Rect[394.85 739.008 458.005 723.67]/Subtype/Link/Type/Annot>> endobj 466 0 obj <> endobj 456 0 obj [467 0 R 468 0 R 469 0 R 470 0 R 471 0 R 472 0 R 473 0 R 474 0 R 475 0 R 476 0 R 477 0 R 478 0 R] endobj 457 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\210\220\222\220\017\016\006\n\220\016 \215\221\002\013\217\001\016\001\220\ \205 \n\013\n \232\225\225\016\n)-9.9(\026\220\r\001\013\205 )]TJ 0 -1 TD [(\013\201\230\212\r\013\001\026\001\013\205 \026)11(\016\002\013\221\220\205 \221\002\220\022\002\016\024\220\006\006\220\220\ \r\025\006\221\013\007\220\026)11(\016\007\216\001\020\207 )]TJ T* [(\222\013\f\025\007\016\r\013\001\220\203 \n\220\016\017\001\220\n\013 \(\ \025\f\222\025\002 \007\220\026)11(\016\002\013\026)-19.9(\215\002\020\))]TJ 43.88 2 Td [(Ph)31(y)10(sical e)21(x)10(er)31(cises as an ef)-30.9(fectiv)12(e adju)10(v)10(ant )]TJ 2.526 -1 Td [(th)11(er)21(apy of IBD in r)31.1(emission \(r)31(e)11(vie)11(w\))]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0.014 Tc 0.511 Tw 8 0 0 8 42.5197 731.2159 Tm [(Phar)-13.9(macol Ther.)]TJ /T1_2 1 Tf [( 2017 Jun;45\(11\):1379\2261389. d)-15.9(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs -0.014 Tw (10.1111/)Tj 0 Tc 0 Tw 0 -1.25 TD (apt.14062)Tj 0 0 0 1 k /GS1 gs 0.273 Tw T* (67.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Al)35(uzai)-23.9(te)]TJ /Span<>> BDC ( )Tj EMC [(K, Al-Mandhar)-36.9(i)]TJ /Span<>> BDC ( )Tj EMC [(R, Osbor)-15(ne)]TJ /Span<>> BDC ( )Tj EMC [(H, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. De)-12(t)15.1(ailed Mul)56(t)-32(i-)]TJ 0.094 Tw -1.796 -1.25 Td [(Dimensional )0.6(Assess)26(ment )0.6(of )0.5(F)20.1(a)15(t)-32(igue )0.5(in )0.6(Infl)-16(amma)15(t)17.1(or)-24(y )0.5(Bo)-14(wel )0.6(Disease. )]TJ /T1_1 1 Tf -0.046 Tw T* [(Inf)-22(lamm Intest Dis)]TJ /T1_2 1 Tf [(. 2019 Ap)25(r;3\(4\):192\226201. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1159/000496054)Tj 0 0 0 1 k /GS1 gs 0.277 Tw T* (68.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(W)-16(iestler)]TJ /Span<>> BDC ( )Tj EMC [(M, K)25(o)-16(ck)10(elmann)]TJ /Span<>> BDC ( )Tj EMC (F, K\374ck)Tj /Span<>> BDC ( )Tj EMC [(M, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Q)-16(ual)-31(i)-23.9(t)-10(y of L)-32(ife Is )]TJ 0.11 Tw -1.796 -1.25 Td [(Asso)-16(c)-23.9(ia)15(ted W)-16(i)-24(t)-13(h W)22(ear)-32.9(able-Based Phy)-13(sical A)-25(c)-16(t)-32(i)-16(v)-16(i)-23.9(t)-10(y in P)40(a)15(t)-32(ients W)-16(i)-23.9(t)-13(h )]TJ 0.248 Tw T* [(Infl)-16(amma)15.1(t)17(or)-24(y Bo)-14(wel Disease: A P)35(r)-32(ospec)-16(t)-32(i)-16(ve, Obser)-31.9(v)-15(a)15(t)-32(ional S)15(tud)17(y. )]TJ /T1_1 1 Tf 0.161 Tw T* [(Clin T)56(ransl Gastroenterol.)]TJ /T1_2 1 Tf [( 2019 N)-14(ov;10\(11\):e00094. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.14309/)Tj T* [(c)-16(tg.0000000000000094)]TJ 0 0 0 1 k /GS1 gs 0.12 Tw T* (69.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(W)-16(il)35(und)]TJ /Span<>> BDC ( )Tj EMC [(KR. Is t)-13(he ant)-31.9(i-infl)-16(amma)15(t)17.1(or)-24(y ef)-56(fec)-16(t of r)-24(egul)-16(ar e)-18(x)12(er)-32(c)-24(ise )]TJ -0.002 Tw -1.796 -1.25 Td [(r)-24(esponsible for r)-23.9(educed car)-24(diov)-15(ascul)-15.9(ar disease? )]TJ /T1_1 1 Tf (Clin Sci \(Lond\))Tj /T1_2 1 Tf (. 2007 )Tj 0.023 Tw T* [(Jun;112\(11\):543\22655. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1042/CS20060368)Tj 0 0 0 1 k /GS1 gs 0.011 Tc 0.421 Tw T* (70.)Tj /Span<>> BDC ( )Tj EMC 1.841 0 Td [(P)29.7(eder)-10.3(sen)]TJ /Span<>> BDC ( )Tj EMC [(BK. Ant)-32.3(i-infl)-16.3(amma)14.7(t)16.6(or)-24.4(y ef)-56.4(fec)-16.3(ts of e)-18.4(x)11.7(er)-32.3(c)-24.3(ise: r)-32.3(ole)11( )]TJ 0 Tc 0.323 Tw -1.841 -1.25 Td [(in diabe)-12(tes and car)-24(diov)-15(ascul)-16(ar disease. )]TJ /T1_1 1 Tf [(Eur J Clin In)11(v)13(est.)]TJ /T1_2 1 Tf ( 2017 )Tj 0.023 Tw T* [(A)10(ug;47\(8\):600\226611. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw [(10.1111/ec)-24(i.12781)]TJ 0 0 0 1 k /GS1 gs 0.018 Tw T* (71.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(S)-24(chmi)-24(tz)]TJ /Span<>> BDC ( )Tj EMC [(KH, Cour)-15(ne)-11(y)22(a)]TJ /Span<>> BDC ( )Tj EMC [(K)-25(S, Ma)15(t)-30(t)-13(hews)]TJ /Span<>> BDC ( )Tj EMC [(C, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Amer)-37(ican College of )]TJ 0.022 Tw 27.259 20 Td [(Spor)-22(ts Medic)-23.9(ine. Amer)-37(ican College of Spor)-21.9(ts Medic)-24(ine r)-32(ound)17(t)15(able on )]TJ 0.088 Tw T* [(e)-18(x)12(er)-31.9(c)-24(ise guidel)-31(ines )0.5(for cancer )0.5(sur)-32(v)-16(i)-16(vor)-9.9(s. )]TJ /T1_1 1 Tf [(Med Sci )0.5(Spor)-40(ts Ex)10(erc)]TJ /T1_2 1 Tf (. 2010 )Tj 0.023 Tw T* [(Jul;42\(7\):1409\22626. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw [(10.1249/MS)17(S.0b013e3181e0c112)]TJ 0 0 0 1 k /GS1 gs 0.3 Tw T* (72.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(F)10(ossa)15(t)-32(i)]TJ /Span<>> BDC ( )Tj EMC [(C, T)45(or)-23.9(r)-24(e)]TJ /Span<>> BDC ( )Tj EMC [(G, Bor)-24(r)-36.9(ione)]TJ /Span<>> BDC ( )Tj EMC [(P, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Biohumor)-32.9(al Indica)15(t)17(or)-10(s )]TJ 0.085 Tw -1.796 -1.25 Td [(Infl)35(uenced b)12(y Phy)-13(sical A)-25(c)-15.9(t)-32(i)-16(v)-16(i)-24(t)-9.9(y in t)-13(he Elder)-30(l)35(y. )]TJ /T1_1 1 Tf (J Clin Med.)Tj /T1_2 1 Tf [( 2020 Ap)25(r )]TJ 0.023 Tw T* [(13;9\(4\):1115. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.3390/jcm9041115)Tj 0 0 0 1 k /GS1 gs -0.075 Tw T* (73.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(W)12(ang)]TJ /Span<>> BDC ( )Tj EMC (Q, Mi)Tj /Span<>> BDC ( )Tj EMC [(S, Y)35(u)]TJ /Span<>> BDC ( )Tj EMC [(Z, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Opening a W)-16(ind)-16(o)-14(w on A)30(t)-30(tent)-32(ion: A)15(d)17(juv)-15(ant )]TJ 0.005 Tc 0.349 Tw -1.796 -1.25 Td [(T)47.1(her)-32.9(apies for Infl)-15.9(amma)15.1(t)17.1(or)-23.9(y Bo)-13.9(wel Disease. )]TJ /T1_1 1 Tf [(Can J Gastroenterol)5( )]TJ 0 Tc 0 Tw T* (Hepatol)Tj /T1_2 1 Tf 0.023 Tw [(. 2020 A)10(ug 12;2020:7397523. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1155/2020/7397523)Tj 0 0 0 1 k /GS1 gs 0.002 Tw T* (74.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Duf)-56(f)]TJ /Span<>> BDC ( )Tj EMC [(W, Hask)10(e)-11(y)]TJ /Span<>> BDC ( )Tj EMC [(N, P)10(o)17(t)-30(ter)]TJ /Span<>> BDC ( )Tj EMC [(G, e)-11.9(t)]TJ /Span<>> BDC ( )Tj EMC [(al. N)-14(on-phar)-15.9(ma)-17(col)30(o)-16(gical t)-13(her)-32.9(apies )]TJ 0.068 Tw -1.796 -1.25 Td [(for infl)-16(amma)15(t)17.1(or)-24(y bo)-14(wel disease: R)13(ecommend)42(a)15(t)-31.9(ions for self-car)-23.9(e and )]TJ -0.015 Tw T* [(phy)-13(sic)-23.9(ian guid)42(ance. )]TJ /T1_1 1 Tf [(W)29(orld J Gastroenterol.)]TJ /T1_2 1 Tf ( 2018 Jul 28;24\(28\):3055\226)Tj 0.023 Tw T* [(3070. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.3748/wjg.v24.i28.3055)Tj 0 0 0 1 k /GS1 gs 0.003 Tc 0.35 Tw T* (75.)Tj /Span<>> BDC ( )Tj EMC 1.809 0 Td (Ng)Tj /Span<>> BDC ( )Tj EMC [(SC, S)-16.3(hi)]TJ /Span<>> BDC ( )Tj EMC (HY, Hamidi)Tj /Span<>> BDC ( )Tj EMC [(N, e)-12.3(t)]TJ /Span<>> BDC ( )Tj EMC [(al. W)19.7(or)-30.3(ld)-17.3(wide inc)-24.3(idence and)3( )]TJ 0 Tc 0.218 Tw -1.809 -1.25 Td [(p)25(r)-24(ev)-15(alence of infl)-15.9(amma)15(t)17(or)-24(y bo)-14(wel disease in t)-13(he 21st centur)-24(y: a )]TJ 0.229 Tw T* [(sy)-13(stema)15.1(t)-32(ic r)-24(ev)-16(iew of popul)-16(a)15(t)-31.9(ion-based studies. )]TJ /T1_1 1 Tf 0 Tw (Lancet)Tj /T1_2 1 Tf 0.229 Tw (. 2017 Dec )Tj 0.023 Tw T* [(23;390\(10114\):2769\2262778. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1016/S0140-6736\(17\)32448-0)Tj /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\214)10(\211\036\033 \035\030\032\t\033)30(\b)42(\032)-21(\240\033\233)]TJ 57.136 0 Td (REVIEW)Tj /T1_3 1 Tf 25 0 0 25 504.6646 56.0378 Tm (161)Tj ET endstream endobj 467 0 obj <>/Border[0 0 0]/H/N/Rect[232.929 738.512 263.622 729.056]/Subtype/Link/Type/Annot>> endobj 468 0 obj <>/Border[0 0 0]/H/N/Rect[42.5197 728.512 75.4235 719.216]/Subtype/Link/Type/Annot>> endobj 469 0 obj <>/Border[0 0 0]/H/N/Rect[197.71 698.512 263.622 689.056]/Subtype/Link/Type/Annot>> endobj 470 0 obj <>/Border[0 0 0]/H/N/Rect[229.71 658.512 263.622 649.056]/Subtype/Link/Type/Annot>> endobj 471 0 obj <>/Border[0 0 0]/H/N/Rect[42.5197 648.512 119.327 639.216]/Subtype/Link/Type/Annot>> endobj 472 0 obj <>/Border[0 0 0]/H/N/Rect[128.844 618.512 198.195 609.216]/Subtype/Link/Type/Annot>> endobj 473 0 obj <>/Border[0 0 0]/H/N/Rect[125.436 588.512 187.371 579.216]/Subtype/Link/Type/Annot>> endobj 474 0 obj <>/Border[0 0 0]/H/N/Rect[355.204 718.512 463.06 709.216]/Subtype/Link/Type/Annot>> endobj 475 0 obj <>/Border[0 0 0]/H/N/Rect[336.933 688.512 406.34 679.216]/Subtype/Link/Type/Annot>> endobj 476 0 obj <>/Border[0 0 0]/H/N/Rect[412.395 658.512 489.851 649.056]/Subtype/Link/Type/Annot>> endobj 477 0 obj <>/Border[0 0 0]/H/N/Rect[310.157 618.512 396.228 609.216]/Subtype/Link/Type/Annot>> endobj 478 0 obj <>/Border[0 0 0]/H/N/Rect[381.381 578.512 490.548 569.216]/Subtype/Link/Type/Annot>> endobj 490 0 obj <> endobj 489 0 obj <> endobj 488 0 obj <> endobj 487 0 obj <> endobj 486 0 obj <> endobj 485 0 obj <> endobj 484 0 obj <> endobj 483 0 obj <> endobj 482 0 obj <> endobj 481 0 obj <> endobj 480 0 obj <> endobj 479 0 obj <> endobj 56 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 57 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 58 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 59 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 60 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 496 0 obj [498 0 R 499 0 R 500 0 R 501 0 R 502 0 R 503 0 R 504 0 R 505 0 R 506 0 R 507 0 R 508 0 R 509 0 R 510 0 R 511 0 R 512 0 R 513 0 R 514 0 R 515 0 R 516 0 R 517 0 R 518 0 R 519 0 R 520 0 R 521 0 R 522 0 R 523 0 R 524 0 R 525 0 R 526 0 R 527 0 R 528 0 R 529 0 R 530 0 R 531 0 R 532 0 R 533 0 R 534 0 R 535 0 R 536 0 R 537 0 R 538 0 R 539 0 R 540 0 R] endobj 497 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.019 Tw 8 0 0 8 70.8661 731.2159 Tm (32.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Mendham)Tj /Span<>> BDC ( )Tj EMC [(AE, Duf)-55.9(f)-28(ield)]TJ /Span<>> BDC ( )Tj EMC [(R, Mar)-37(ino)]TJ /Span<>> BDC ( )Tj EMC [(F, Cout)-30(ts)]TJ /Span<>> BDC ( )Tj EMC (AJ. Small-sided games )Tj 0.277 Tw -1.796 -1.25 Td [(tr)-33(aining )0.5(r)-23.9(educes )0.5(CRP, )0.5(IL-6 )0.5(and )0.5(lept)-32(in )0.5(in )0.5(sedent)15(ar)-24(y, )0.5(middle-a)-17(ged )]TJ 0 Tw 0 -1.25 TD (men. )Tj /T1_1 1 Tf 0.078 Tw 2.314 0 Td [(Eur J Appl Ph)12(ysiol)]TJ /T1_0 1 Tf [(. 2014 N)-13.9(ov;114\(11\):2289\22697. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1007/)Tj -2.314 -1.25 Td (s00421-014-2953-3)Tj 0 0 0 1 k /GS1 gs 0.09 Tw T* (33.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Beaver)-9.9(s)]TJ /Span<>> BDC ( )Tj EMC [(KM, Br)-37(inkle)-10.9(y)]TJ /Span<>> BDC ( )Tj EMC [(TE, Nickl)-15.9(as)]TJ /Span<>> BDC ( )Tj EMC [(BJ. Ef)-55.9(fec)-16(t of e)-18(x)12(er)-31.9(c)-24(ise tr)-33(aining )]TJ -0.03 Tw -1.796 -1.25 Td [(on )0.5(chr)-31.9(onic )0.5(infl)-15.9(amma)15(t)-32(ion. )0.6(R)13(ev)-16(iew. )]TJ /T1_1 1 Tf 13.699 0 Td [(Clin )0.6(Chim )0.5(Acta.)]TJ /T1_0 1 Tf [( )0.5(2010 )0.6(Jun )0.5(3;411\(11-)]TJ 0.023 Tw -13.699 -1.25 Td [(12\):785\22693. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1016/j.cca.2010.02.069)Tj 0 0 0 1 k /GS1 gs 0.166 Tw T* (34.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(L)35(oud)-16(on)]TJ /Span<>> BDC ( )Tj EMC [(CP, Cor)-24(r)-32(oll)]TJ /Span<>> BDC ( )Tj EMC (V, Butcher)Tj /Span<>> BDC ( )Tj EMC [(J, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. T)46.9(he ef)-56(fec)-15.9(ts of phy)-12.9(sical )]TJ 0.072 Tw -1.796 -1.25 Td [(e)-18(x)12(er)-32(c)-23.9(ise )0.5(on )0.5(p)32(a)15(t)-31.9(ients )0.5(wi)-23.9(t)-13(h )0.5(Cr)-32(ohn\245s )0.6(disease. )]TJ /T1_1 1 Tf 17.474 0 Td [(Am )0.6(J )0.5(Gastroenterol.)]TJ /T1_0 1 Tf [( )0.6(1999 )]TJ 0.023 Tw -17.474 -1.25 Td [(Mar;94\(3\):697\226703. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1111/j.1572-0241.1999.00939.x)Tj 0 0 0 1 k /GS1 gs 0.086 Tw T* (35.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (D\245Inc\340)Tj /Span<>> BDC ( )Tj EMC 2.852 0 Td [(R, )0.5(V)25(ar)-14.9(nier)]TJ /Span<>> BDC ( )Tj EMC 4.197 0 Td [(M, )0.5(Mestr)-36.9(iner)]TJ /Span<>> BDC ( )Tj EMC 5.296 0 Td [(C, )0.5(e)-12(t)]TJ /Span<>> BDC ( )Tj EMC 2.12 0 Td [(al. )0.6(Ef)-56(fec)-16(t )0.5(of )0.6(moder)-33(a)15(te )0.6(e)-18(x)12(er)]TJ 0 Tw 11.025 0 Td (-)Tj 0.185 Tw -27.286 -1.25 Td [(c)-24(ise )0.5(on Cr)-32(ohn\245s disease )0.5(p)32(a)15(t)-32(ients )0.5(in r)-24(emission. )]TJ /T1_1 1 Tf 19.702 0 Td [(Ital )0.5(J Gastroenterol )]TJ 0.01 Tc -0.01 Tw -19.702 -1.25 Td (Hepatol)Tj /T1_0 1 Tf 0.389 Tw [(. 1999 Ap)24.5(r;31\(3\):205\22610. ht)-30.5(tps://pubmed.ncbi.nlm.nih.)]TJ 0 Tc 0 Tw T* (gov/10379481/)Tj 0.306 Tw T* (36.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Ng)Tj /Span<>> BDC ( )Tj EMC [(V, Mill)-16(ar)-24(d)]TJ /Span<>> BDC ( )Tj EMC [(W, L)35(ebr)-22(un)]TJ /Span<>> BDC ( )Tj EMC [(C, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. E)35(x)12(er)-31.9(c)-24(ise and Cr)-31.9(ohn\245s dis)]TJ 0 Tw (-)Tj 0.102 Tw -1.796 -1.25 Td [(ease: specul)-15.9(a)15(t)-32(ions on po)17(tent)-31.9(ial benef)-28(i)-24(ts. )]TJ /T1_1 1 Tf (Can J Gastroenterol)Tj /T1_0 1 Tf (. 2006 )Tj 0.023 Tw T* [(O)-16(c)-16(t;20\(10\):657\22660. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1155/2006/462495)Tj 0 0 0 1 k /GS1 gs 0.034 Tw T* (37.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Ng)Tj /Span<>> BDC ( )Tj EMC 1.356 0 Td [(V, )0.5(Mill)-16(ar)-24(d)]TJ /Span<>> BDC ( )Tj EMC 4 0 Td [(W, )0.5(L)35(ebr)-22(un)]TJ /Span<>> BDC ( )Tj EMC 4.172 0 Td [(C, )0.5(e)-12(t)]TJ /Span<>> BDC ( )Tj EMC 2.016 0 Td [(al. )0.5(L)35(o)-14(w-intensi)-23.9(t)-10(y )0.5(e)-18(x)12(er)-32(c)-24(ise )0.5(im)10(p)25(r)-31.9(oves )]TJ -0.012 Tw -13.339 -1.25 Td [(qual)-30.9(i)-24(t)-10(y )0.5(of )0.5(l)-31(ife )0.5(in )0.5(p)32(a)15(t)-32(ients )0.5(wi)-23.9(t)-13(h )0.5(Cr)-32(ohn\245s )0.5(disease. )]TJ /T1_1 1 Tf 18.891 0 Td [(Clin )0.5(J )0.5(Spor)-40(t )0.5(Med.)]TJ /T1_0 1 Tf [( )0.5(2007 )]TJ 0.023 Tw -18.891 -1.25 Td [(Sep;17\(5\):384\2268. d)-15.9(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw [(10.1097/JSM.0b013e31802b4fd)42(a)]TJ 0 0 0 1 k /GS1 gs 0.249 Tw T* (38.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(T)40(ew)]TJ /Span<>> BDC ( )Tj EMC (GA, Jones)Tj /Span<>> BDC ( )Tj EMC [(K, Miko)-15.9(ck)-17(a-W)12(al)35(us)]TJ /Span<>> BDC ( )Tj EMC [(A. Phy)-13(sical A)-25(c)-16(t)-32(i)-16(v)-16(i)-23.9(t)-10(y Habi)-24(ts, )]TJ 0.001 Tc 0.349 Tw -1.796 -1.25 Td [(L)-31.5(im)0.5(i)-23.6(t)15.5(a)15.4(t)-31.5(io)0.5(ns,)0.5( and)0.5( P)35.4(r)-23.5(ed)0.5(ic)-15.5(t)17.4(o)0.5(r)-9.6(s)0.5( i)0.5(n P)30.5(eop)0.5(le)0.5( w)0.5(i)-23.5(t)-12.6(h)0.5( Inf)0.5(l)-15.5(amm)0.5(a)15.4(t)17.5(or)-23.5(y B)0.5(o)-13.6(w)0.5(el)1( )]TJ 0 Tc 0.093 Tw T* [(Disease: A L)-32(ar)-32(ge Cr)-32(oss-sec)-16(t)-32(ional Onl)-31(ine Sur)-31.9(ve)-11(y. )]TJ /T1_1 1 Tf [(Inf)-21.9(lamm Bow)12.1(el Dis)]TJ /T1_0 1 Tf 0 Tw (. )Tj 0.022 Tw T* [(2016 Dec;22\(12\):2933\2262942. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1097/MIB.0000000000000962)Tj 0 0 0 1 k /GS1 gs 0.012 Tc 0.437 Tw T* (39.)Tj /Span<>> BDC ( )Tj EMC 1.843 0 Td [(Nar)-21.8(ul)-15.8(a)]TJ /Span<>> BDC ( )Tj EMC [(N, F)10.2(ed)-15.8(or)-32.8(ak)]TJ /Span<>> BDC ( )Tj EMC [(RN. E)35.2(x)12.2(er)-31.8(c)-23.8(ise and infl)-15.8(amma)15.2(t)17.2(or)-23.8(y bo)-13.9(wel)12( )]TJ 0.024 Tc -0.024 Tw -1.843 -1.25 Td (disease. )Tj /T1_1 1 Tf 0.862 Tw 4.561 0 Td (Can J Gastroenterol)Tj /T1_0 1 Tf [(. 2008 Ma)15.1(y;22\(5\):497\226504.)24( )]TJ 0 Tc 0 Tw -4.561 -1.25 Td [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1155/2008/785953)Tj 0 0 0 1 k /GS1 gs 0.02 Tc 0.301 Tw -1.847 -1.25 Td (40.)Tj /Span<>> BDC ( )Tj EMC 1.876 0 Td [(Subr)-33(amaniam)]TJ /Span<>> BDC ( )Tj EMC [(K, T)40(ymms)]TJ /Span<>> BDC ( )Tj EMC [(K, S)-16(hadbol)56(t)]TJ /Span<>> BDC ( )Tj EMC [(B, e)-11.9(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Spond)17(yl)30(oar)]TJ /Span<>> BDC (-)Tj EMC 0.068 Tw -1.876 -1.25 Td [(t)-13(hr)-32(op)32(a)15(t)-13(hy in infl)-16(amma)15(t)17(or)-24(y bo)-14(wel disease p)32(a)15(t)-32(ients on TNF inhibi)]TJ 0 Tc 0 Tw (-)Tj 0.02 Tc -0.02 Tw T* [(t)17(or)-10(s. )]TJ /T1_1 1 Tf 0.314 Tw 2.512 0 Td [(Inter)-13.9(n Med)]TJ /Span<>> BDC ( )Tj EMC (J.)Tj /T1_0 1 Tf [( 2015 N)-14(ov;45\(11\):1154\22660. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs -0.02 Tw (10.1111/)Tj -2.512 -1.25 Td (imj.12891)Tj 0 0 0 1 k /GS1 gs 0 Tc -0.047 Tw T* (41.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(P)40(ap)32(adimi)-24(tr)-36.9(iou)]TJ /Span<>> BDC ( )Tj EMC 5.856 0 Td [(K. )0.5(Ef)-56(fec)-16(t )0.5(of )0.5(r)-24(esist)15.1(ance )0.5(e)-18(x)12(er)-32(c)-24(ise )0.5(tr)-33(aining )0.5(on )0.5(Cr)-32(ohn\245s )]TJ 0.038 Tw -7.652 -1.25 Td [(disease p)32(a)15(t)-32(ients. )]TJ /T1_1 1 Tf [(Intest R)21(es.)]TJ /T1_0 1 Tf [( 2021 Jul;19\(3\):275\226281. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.5217/)Tj T* (ir.2020.00043)Tj 0 0 0 1 k /GS1 gs 0.158 Tw T* (42.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(de S)-16(ouza T)40(ajir)-37(i)]TJ /Span<>> BDC ( )Tj EMC [(GJ, de Castr)-31.9(o)]TJ /Span<>> BDC ( )Tj EMC [(CL, Z)10.1(al)56(tman)]TJ /Span<>> BDC ( )Tj EMC [(C. P)35(r)-32(o)-16(gr)-24(essi)-15.9(ve r)-24(esis)]TJ 0 Tw (-)Tj 0.11 Tw -1.796 -1.25 Td [(t)15(ance tr)-33(aining im)10(p)25(r)-32(oves muscle str)-24(eng)17(t)-13(h in w)-14(omen wi)-24(t)-13(h infl)-15.9(amma)]TJ 0 Tw (-)Tj 0.104 Tw T* [(t)17(or)-24(y bo)-14(wel disease and quadr)-37(iceps weakness. )]TJ /T1_1 1 Tf (J Crohns Colitis.)Tj /T1_0 1 Tf ( 2014 )Tj 0.023 Tw T* [(Dec;8\(12\):1749\22650. d)-15.9(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw [(10.1016/j.cr)-32(ohns.2014.09.001)]TJ 0 0 0 1 k /GS1 gs -0.026 Tw T* (43.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(El-K)-15.9(ader)]TJ /Span<>> BDC ( )Tj EMC [(SMA, Al-S)-15.9(hr)-24(eef)]TJ /Span<>> BDC ( )Tj EMC [(FM. Infl)-15.9(amma)15(t)17(or)-23.9(y cy)-16(t)17(ok)-16(ines and immune )]TJ 0.125 Tw -1.796 -1.25 Td [(sy)-13(stem modul)-16(a)15(t)-32(ion b)12(y aer)-32(obic ver)-9.9(sus r)-24(esisted e)-18(x)12(er)-31.9(c)-24(ise tr)-33(aining for )]TJ 0 Tw T* [(elder)-30(l)35(y. )]TJ /T1_1 1 Tf 0.1 Tw 3.336 0 Td (Afr Health Sci)Tj /T1_0 1 Tf [(. 2018 Mar;18\(1\):120\226131. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.4314/ahs.)Tj -3.336 -1.25 Td (v18i1.16)Tj 0 0 0 1 k /GS1 gs 0.01 Tw T* (44.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Khal)-31(il)-30.9(i)]TJ /Span<>> BDC ( )Tj EMC [(H, Anant)-12.9(hakr)-37(ishnan)]TJ /Span<>> BDC ( )Tj EMC [(A)51(N, K)25(onije)-12(t)-32(i)]TJ /Span<>> BDC ( )Tj EMC [(GG, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Phy)-12.9(sical a)-17(c)-16(t)-32(i)-16(v)]TJ 0 Tw 25.49 0 Td (-)Tj 0.099 Tw -27.286 -1.25 Td [(i)-24(t)-10(y and r)-37(isk of infl)-16(amma)15(t)17(or)-23.9(y bo)-14(wel disease: p)25(r)-32(ospec)-15.9(t)-32(i)-16(ve stud)17(y fr)-32(om )]TJ 0.271 Tw T* [(t)-13(he Nur)-10(ses\245 Heal)56.1(t)-13(h S)15(tud)17.1(y cohor)-22(ts. )]TJ /T1_1 1 Tf 0 Tw (BMJ)Tj /T1_0 1 Tf 0.271 Tw [(. 2013 N)-14(ov 14;347:f6633. )]TJ 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1136/bmj.f6633)Tj 0 0 0 1 k /GS1 gs -0.068 Tw -1.847 -1.25 Td (45.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(S)15(teell)]TJ /Span<>> BDC ( )Tj EMC [(L, G)20(r)-32.9(a)14.9(y)]TJ /Span<>> BDC ( )Tj EMC (SR, Russell)Tj /Span<>> BDC ( )Tj EMC [(RK, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. P)40(a)15(t)-13(ho)-16(genesis of Muscul)30(osk)10(ele)-12(t)15(al )]TJ 0.188 Tw -1.796 -1.25 Td [(Def)-28(ic)-24(i)-23.9(ts in )0.5(Childr)-23.9(en )0.5(and A)15.1(dul)56(ts )0.5(wi)-24(t)-13(h )0.5(Infl)-16(amma)15.1(t)17(or)-24(y )0.5(Bo)-14(wel )0.5(Disease. )]TJ /T1_1 1 Tf 0 Tw T* [(N)21(utr)-37(ients)]TJ /T1_0 1 Tf 0.023 Tw [(. 2021 A)10(ug 23;13\(8\):2899. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.3390/nu13082899)Tj 0 0 0 1 k /GS1 gs 0.017 Tw T* (46.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(T)40(ar)-32(go)-14(wnik)]TJ /Span<>> BDC ( )Tj EMC [(LE, Ber)-15(nstein)]TJ /Span<>> BDC ( )Tj EMC (CN, Nugent)Tj /Span<>> BDC ( )Tj EMC [(Z, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Infl)-16(amma)15.1(t)17(or)-24(y bo)-14(wel )]TJ 0.243 Tw -1.796 -1.25 Td [(disease has a s)26(mall ef)-56(fec)-16(t on bone miner)-33(al densi)-24(t)-9.9(y and r)-37(isk for )]TJ 0 Tw T* [(osteopor)-32(osis. )]TJ /T1_1 1 Tf 0.274 Tw 5.917 0 Td (Clin Gastroenterol Hepatol.)Tj /T1_0 1 Tf ( 2013 Mar;11\(3\):278\22685. )Tj 0 Tw -5.917 -1.25 Td [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1016/j.cgh.2012.10.022)Tj 0 0 0 1 k /GS1 gs 0.02 Tw -1.847 -1.25 Td (47.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(R)11(obinson)]TJ /Span<>> BDC ( )Tj EMC [(RJ, Kr)-24(zywick)-15.9(i)]TJ /Span<>> BDC ( )Tj EMC (T, Almond)Tj /Span<>> BDC ( )Tj EMC [(L, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Ef)-56(fec)-16(t of a l)30(o)-14(w-im)10(p)32(a)-17(c)-16(t )]TJ 0.044 Tw -1.796 -1.25 Td [(e)-18(x)12(er)-32(c)-23.9(ise p)25(r)-32(o)-16(gr)-33(am on bone miner)-33(al densi)-23.9(t)-10(y in Cr)-32(ohn\245s disease: a r)-32.9(an)]TJ 0 Tw (-)Tj 0.113 Tw T* [(d)-16(omized contr)-32(olled tr)-36.9(ial. )]TJ /T1_1 1 Tf 0 Tw (Gastroenterology)Tj /T1_0 1 Tf 0.113 Tw (. 1998 Jul;115\(1\):36\22641. )Tj 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1016/s0016-5085\(98\)70362-2)Tj 0 0 0 1 k /GS1 gs 0.225 Tw -1.847 -1.25 Td (48.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Melek)Tj /Span<>> BDC ( )Tj EMC [(J, Sakur)-33(aba)]TJ /Span<>> BDC ( )Tj EMC [(A. Ef)-56(f)-28(ica)-17(cy and safe)-12(t)-10(y of medical t)-13(her)-33(apy )]TJ 0.151 Tw -1.796 -1.25 Td [(for l)30(o)-14(w bone miner)-32.9(al densi)-24(t)-10(y in p)32(a)15(t)-32(ients wi)-23.9(t)-13(h infl)-16(amma)15.1(t)17(or)-24(y bo)-14(wel )]TJ 0.187 Tw T* [(disease: a me)-11.9(t)15(a-anal)35(y)-13(sis and sy)-13(stema)15(t)-32(ic r)-23.9(ev)-16(iew. )]TJ /T1_1 1 Tf (Clin Gastroenterol )Tj 0 Tw T* (Hepatol.)Tj /T1_0 1 Tf 0.023 Tw [( 2014 Jan;12\(1\):32\22644.e5. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1016/j.cgh.2013.08.024)Tj 0 0 0 1 k /GS1 gs 0.15 Tw T* (49.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Jones)Tj /Span<>> BDC ( )Tj EMC [(K, Bak)10(er)]TJ /Span<>> BDC ( )Tj EMC (K, Speight)Tj /Span<>> BDC ( )Tj EMC [(RA, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. R)-10(and)-16(omised cl)-31(inical tr)-37(ial: )]TJ 0.001 Tc 0.349 Tw -1.796 -1.25 Td [(c)0.5(o)0.6(m)0.5(b)0.5(i)0.6(n)0.5(e)0.6(d)0.5( i)0.5(m)10.5(p)32.6(a)-16.5(c)-15.5(t)0.6( a)0.5(n)0.5(d)0.6( r)-23.4(e)0.5(s)0.6(i)0.5(s)0.6(t)15.5(a)0.5(n)0.6(c)0.5(e)0.5( t)0.6(r)-32.5(a)0.6(i)0.5(n)0.5(i)0.6(n)0.5(g)0.5( i)0.6(n)0.5( a)0.6(d)0.5(u)0.6(l)56.5(t)0.6(s)0.5( w)0.5(i)-23.4(t)-12.5(h)0.5( s)0.6(t)15.5(a)0.5(b)0.6(l)0.5(e)1( )]TJ 0 Tc 0.125 Tw T* [(Cr)-32(ohn\245s disease. )]TJ /T1_1 1 Tf [(Aliment Phar)-14(macol Ther.)]TJ /T1_0 1 Tf ( 2020 Sep;52\(6\):964\226975. )Tj 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1111/apt.16002)Tj 0 0 0 1 k /GS1 gs 0.078 Tw -1.847 -1.25 Td (50.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(T)50(r)-37(i)-16(v)-15.9(i\265)]TJ /Span<>> BDC ( )Tj EMC [(I, S)-16(il)-16(a)]TJ /Span<>> BDC ( )Tj EMC (S, Mi\266ak)Tj /Span<>> BDC ( )Tj EMC [(Z, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Im)10(p)32(a)-17(c)-16(t of an e)-18(x)12(er)-32(c)-24(ise p)25(r)-32(o)-16(gr)-33(am in )]TJ 0.07 Tw 27.259 81.25 Td [(childr)-23.9(en wi)-24(t)-13(h infl)-16(amma)15(t)17(or)-23.9(y bo)-14(wel disease in r)-23.9(emission. )]TJ /T1_1 1 Tf [(P)14.9(ediatr R)21(es.)]TJ /T1_0 1 Tf 0 Tw ( )Tj 0.023 Tw T* [(2022 N)-14(ov 1:1\2266. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1038/s41390-022-02362-8)Tj 0 0 0 1 k /GS1 gs 0.12 Tw T* (51.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Har)-24(bor)-23.9(d)]TJ /Span<>> BDC ( )Tj EMC (M, Annese)Tj /Span<>> BDC ( )Tj EMC [(V, V)25(avr)-36.9(ick)-17(a)]TJ /Span<>> BDC ( )Tj EMC [(SR, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Eur)-32(opean Cr)-31.9(ohn\245s and )]TJ -1.796 -1.25 Td [(Col)-31(i)-23.9(t)-32(is Or)-32(ganisa)15(t)-32(ion. T)47(he F)-19(ir)-10(st Eur)-32(opean Ev)-16(idence-based Consensus )]TJ 0.043 Tw T* [(on E)35(xtr)-33(a-intest)-31.9(inal Manifest)15.1(a)15(t)-32(ions in Infl)-16(amma)15(t)17(or)-23.9(y Bo)-14(wel Disease. )]TJ /T1_1 1 Tf 0 Tw (J )Tj -0.015 Tw T* (Crohns Colitis.)Tj /T1_0 1 Tf [( 2016 Mar;10\(3\):239\22654. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1093/ecco-jcc/jjv213)Tj 0 0 0 1 k /GS1 gs 0.001 Tw T* (52.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Hommes)Tj /Span<>> BDC ( )Tj EMC [(D, Col)30(ombel)]TJ /Span<>> BDC ( )Tj EMC [(JF, Emer)-24(y)]TJ /Span<>> BDC ( )Tj EMC [(P, e)-11.9(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Changing Cr)-32(ohn\245s disease )]TJ 0.217 Tw -1.796 -1.25 Td [(mana)-17(gement: need for new goals and indices t)17(o p)25(r)-24(event disabil)]TJ 0 Tw (-)Tj 0.161 Tw T* [(i)-24(t)-10(y and im)10.1(p)24.9(r)-31.9(ove qual)-31(i)-23.9(t)-10(y of l)-31(ife. )]TJ /T1_1 1 Tf (J Crohns Colitis.)Tj /T1_0 1 Tf [( 2012 F)10(eb;6 Suppl )]TJ 0.023 Tw T* [(2:S224\22634. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1016/S1873-9946\(12\)60502-9)Tj 0 0 0 1 k /GS1 gs -0.019 Tw T* (53.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(E)15(ck)10(er)-21.9(t)]TJ /Span<>> BDC ( )Tj EMC [(K)15(G, A)-14(bbasi-Neur)-23.9(ei)-24(t)-13(her)]TJ /Span<>> BDC ( )Tj EMC (I, K\366ppel)Tj /Span<>> BDC ( )Tj EMC [(M, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. S)15(tr)-22(uc)-15.9(tur)-24(ed phy)-13(si)]TJ 0 Tw (-)Tj 0.117 Tw -1.796 -1.25 Td [(cal a)-17(c)-16(t)-32(i)-15.9(v)-16(i)-24(t)-10(y inter)-31.9(vent)-32(ions as a com)10(plement)15(ar)-24(y t)-13(her)-32.9(apy for p)32(a)15(t)-32(ients )]TJ 0.083 Tw T* [(wi)-24(t)-12.9(h infl)-15.9(amma)15(t)17(or)-24(y bo)-14(wel disease)]TJ /Span<>> BDC ( )Tj EMC [(\227 a scoping r)-24(ev)-16(iew and p)25(r)-33(a)-17(c)-16(t)-32(ical )]TJ 0 Tw T* [(im)10(pl)-31(ica)15.1(t)-32(ions. )]TJ /T1_1 1 Tf -0.026 Tw 5.52 0 Td (BMC Gastroenterol.)Tj /T1_0 1 Tf [( 2019 Jul 2;19\(1\):115. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1186/)Tj -5.52 -1.25 Td (s12876-019-1034-9)Tj 0 0 0 1 k /GS1 gs 0.193 Tw T* (54.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Jones)Tj /Span<>> BDC ( )Tj EMC 2.752 0 Td (K, Kimble)Tj /Span<>> BDC ( )Tj EMC 4.298 0 Td [(R, Bak)10(er)]TJ /Span<>> BDC ( )Tj EMC 3.791 0 Td [(K, e)-11.9(t)]TJ /Span<>> BDC ( )Tj EMC 2.385 0 Td [(al. )0.5(Ef)-56(fec)-16(ts )0.5(of str)-22(uc)-15.9(tur)-24(ed e)-18(x)12.1(er)]TJ 0 Tw 12.264 0 Td (-)Tj 0.007 Tc 0.35 Tw -27.286 -1.25 Td [(c)-24(ise )0.5(p)25(r)-32.1(o)-16(gr)-33(ammes )0.5(on )0.5(phy)-13(siol)29.9(o)-16(gical )0.5(and )0.5(psychol)30(o)-16.1(gical )0.5(outcomes)7( )]TJ 0 Tc 0.333 Tw T* [(in )0.5(adul)56(ts )0.5(wi)-24(t)-13(h )0.5(infl)-15.9(amma)15(t)17(or)-24(y )0.5(bo)-14(wel )0.5(disease )0.5(\(IBD\): )0.5(A )0.5(sy)-13(stema)15(t)-32(ic )]TJ 0.117 Tw T* [(r)-24(ev)-15.9(iew )0.5(and )0.6(me)-12(t)15(a-anal)35(y)-13(sis. )]TJ /T1_1 1 Tf 11.004 0 Td [(PLoS )0.6(One.)]TJ /T1_0 1 Tf [( )0.6(2022 )0.5(Dec )0.6(1;17\(12\):e0278480. )]TJ 0 Tw -11.004 -1.25 Td [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td [(10.1371/jour)-14.9(nal.pone.0278480)]TJ 0 0 0 1 k /GS1 gs 0.003 Tw -1.847 -1.25 Td (55.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Na)15(t)-13(han)]TJ /Span<>> BDC ( )Tj EMC [(I, N)-13.9(or)-22(t)17(on)]TJ /Span<>> BDC ( )Tj EMC [(C, Czuber-Do)-16(chan)]TJ /Span<>> BDC ( )Tj EMC [(W, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. E)35(x)12(er)-31.9(c)-24(ise in indi)-16(v)-16(idu)]TJ 0 Tw (-)Tj 0.085 Tw -1.796 -1.25 Td [(als wi)-23.9(t)-13(h infl)-16(amma)15(t)17.1(or)-24(y bo)-14(wel disease. )]TJ /T1_1 1 Tf [(Gastroenterol N)21(urs.)]TJ /T1_0 1 Tf [( 2013 N)-14(ov-)]TJ 0.023 Tw T* [(Dec;36\(6\):437\22642. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1097/SGA.0000000000000005)Tj 0 0 0 1 k /GS1 gs -0.023 Tw T* (56.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(L)35(ov\351n W)-16(ickman)]TJ /Span<>> BDC ( )Tj EMC [(U, Y)30.1(ngman-Uhl)-31(in)]TJ /Span<>> BDC ( )Tj EMC [(P, Hjor)-22(tsw)-12(ang)]TJ /Span<>> BDC ( )Tj EMC [(H, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Self-Car)-24(e )]TJ 0.265 Tw -1.796 -1.25 Td [(Among P)40(a)15(t)-32(ients )0.5(W)-16(i)-24(t)-13(h Infl)-15.9(amma)15(t)17(or)-24(y Bo)-14(wel )0.5(Disease: An Inter)-31.9(v)-16(iew )]TJ 0 Tw T* [(S)15(tud)17(y. )]TJ /T1_1 1 Tf 0.04 Tw 2.815 0 Td [(Gastroenterol N)21.1(urs)]TJ /T1_0 1 Tf [(. 2016 Mar-Ap)25(r;39\(2\):121\2268. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1097/)Tj -2.815 -1.25 Td (SGA.0000000000000120)Tj 0 0 0 1 k /GS1 gs -0.034 Tw T* (57.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(K)-16(aur)]TJ /Span<>> BDC ( )Tj EMC [(S, D\245S)-16(il)30(v)-15(a)]TJ /Span<>> BDC ( )Tj EMC [(A, R)-10(aja)-17(gop)32(al)-16(an)]TJ /Span<>> BDC ( )Tj EMC [(V, e)-11.9(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Ev)-15(al)35(ua)15(t)-31.9(ion of an integr)-33(a)15(ted )]TJ 0.112 Tw -1.796 -1.25 Td [(yo)-16(ga p)25(r)-32(o)-16(gr)-33(am in p)32(a)15(t)-32(ients wi)-24(t)-12.9(h infl)-16(amma)15.1(t)17(or)-24(y bo)-14(wel disease: )]TJ /T1_1 1 Tf [(A pilo)13(t )]TJ 0.135 Tw T* [(study. )0.5(Explore )0.6(\(NY\))]TJ /T1_0 1 Tf [(. )0.5(2022 )0.5(Ma)15(y-Jun;18\(3\):335\226341. )0.5(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw 23.324 0 Td (10.1016/j.)Tj -23.324 -1.25 Td [(e)-18(xpl)30(or)-23.9(e.2021.04.006)]TJ 0 0 0 1 k /GS1 gs 0.255 Tw T* (58.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Ga)15(t)-30(t)]TJ /Span<>> BDC ( )Tj EMC [(K, S)-24(chembr)-37(i)]TJ /Span<>> BDC ( )Tj EMC [(J, K)-16(a)15(tsanos)]TJ /Span<>> BDC ( )Tj EMC [(KH, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Infl)-15.9(amma)15(t)17(or)-24(y Bo)-14(wel )]TJ 0.288 Tw -1.796 -1.25 Td [(Disease [IBD] and Phy)-13(sical A)-24.9(c)-16(t)-32(i)-16(v)-16(i)-23.9(t)-10(y: A S)15(tud)17.1(y on t)-13(he Im)10(p)32(a)-17(c)-16(t of )]TJ 0.194 Tw T* [(Dia)-17(gnosis )0.5(on )0.5(t)-13(he )0.5(L)35(evel )0.5(of )0.5(E)35(x)12.1(er)-32(c)-24(ise )0.5(Amongst )0.5(P)40(a)15(t)-32(ients )0.5(W)-15.9(i)-24(t)-13(h)]TJ /Span<>> BDC ( )Tj EMC 25.001 0 Td (IBD. )Tj /T1_1 1 Tf 0 Tw 2.198 0 Td (J )Tj 0.096 Tw -27.2 -1.25 Td (Crohns Colitis)Tj /T1_0 1 Tf [(. 2019 Ma)15(y 27;13\(6\):686\226692. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1093/ecco-jcc/)Tj T* (jjy214)Tj 0 0 0 1 k /GS1 gs 0.112 Tw T* (59.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Cr)-32(onin)]TJ /Span<>> BDC ( )Tj EMC [(O, Bar)-22(t)17(on)]TJ /Span<>> BDC ( )Tj EMC [(W, M)-24(or)-33(an)]TJ /Span<>> BDC ( )Tj EMC [(C, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. M)-23.9(oder)-33(a)15(te-intensi)-23.9(t)-10(y aer)-32(obic )]TJ 0.123 Tw -1.796 -1.25 Td [(and r)-24(esist)15.1(ance e)-18(x)12(er)-31.9(c)-24(ise is safe and f)16(avor)-33(abl)35(y infl)35(uences bod)17(y com)]TJ 0 Tw (-)Tj 0.116 Tw T* [(posi)-24(t)-32(ion in p)32(a)15(t)-32(ients wi)-24(t)-13(h quiescent Infl)-16(amma)15(t)17(or)-24(y Bo)-13.9(wel Disease: a )]TJ 0.062 Tw T* [(r)-33(and)-16(omized )0.5(contr)-32(olled cr)-32(oss-over )0.5(tr)-37(ial. )]TJ /T1_1 1 Tf 16.191 0 Td (BMC Gastroentero)Tj /T1_0 1 Tf [(l. 2019 F)10(eb )]TJ 0.023 Tw -16.191 -1.25 Td [(12;19\(1\):29. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1186/s12876-019-0952-x)Tj 0 0 0 1 k /GS1 gs 0.172 Tw T* (60.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Jones)Tj /Span<>> BDC ( )Tj EMC [(PD, K)-16(appelman)]TJ /Span<>> BDC ( )Tj EMC [(MD, Mar)-22(t)-32(in)]TJ /Span<>> BDC ( )Tj EMC [(CF, e)-11.9(t)]TJ /Span<>> BDC ( )Tj EMC [(al. E)35(x)12(er)-31.9(c)-24(ise decr)-24(eases )]TJ 0.18 Tw -1.796 -1.25 Td [(r)-37(isk of futur)-23.9(e a)-17(c)-16(t)-32(i)-15.9(ve disease in p)32(a)15(t)-32(ients wi)-23.9(t)-13(h infl)-15.9(amma)15(t)17(or)-24(y bo)-14(wel )]TJ 0.097 Tw T* [(disease in r)-24(emission. )]TJ /T1_1 1 Tf [(Inf)-21.9(lamm Bow)12(el Dis)]TJ /T1_0 1 Tf [(. 2015 Ma)15(y;21\(5\):1063\22671. )]TJ 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1097/MIB.0000000000000333)Tj 0 0 0 1 k /GS1 gs 0.028 Tw -1.847 -1.25 Td (61.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Kim)Tj /Span<>> BDC ( )Tj EMC (B, Chae)Tj /Span<>> BDC ( )Tj EMC (J, Kim)Tj /Span<>> BDC ( )Tj EMC [(EH, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Phy)-12.9(sical a)-17(c)-16(t)-32(i)-16(v)-16(i)-23.9(t)-10(y and qual)-30.9(i)-24(t)-10(y of l)-31(ife )]TJ 0.097 Tw -1.796 -1.25 Td [(of p)32(a)15(t)-32(ients wi)-24(t)-13(h infl)-15.9(amma)15(t)17(or)-24(y bo)-14(wel disease. )]TJ /T1_1 1 Tf (Medicine \(Baltimore\). )Tj /T1_0 1 Tf 0.023 Tw T* [(2021 Jul 9;100\(27\):e26290. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1097/MD.0000000000026290)Tj 0 0 0 1 k /GS1 gs 0.001 Tc 0.35 Tw T* (62.)Tj /Span<>> BDC ( )Tj EMC 1.8 0 Td [(Hol)-31(ik)]TJ /Span<>> BDC ( )Tj EMC 2.716 0 Td [(D, )0.5(V\267ev)]TJ /Span<>> BDC ( )Tj EMC 3.762 0 Td [(A, )0.5(Mil)29.9(ost)-32.1(i\265-Sr)-24(b)]TJ /Span<>> BDC ( )Tj EMC 6.739 0 Td [(A, )0.5(e)-12(t)]TJ /Span<>> BDC ( )Tj EMC 2.741 0 Td [(al. )0.5(T)46.9(he )0.5(ef)-56.1(fec)-16.1(t )0.5(of )0.5(d)42(ail)35(y)1( )]TJ 0 Tc 0.231 Tw -17.758 -1.25 Td [(phy)-13(sical a)-17(c)-16(t)-32(i)-16(v)-16(i)-23.9(t)-10(y on t)-13(he a)-17(c)-16(t)-32(i)-16(v)-16(i)-23.9(t)-10(y of infl)-15.9(amma)15(t)17(or)-24(y bo)-13.9(wel diseases )]TJ 0.12 Tw T* [(in t)-13(her)-33(apy-fr)-23.9(ee p)32(a)14.9(t)-31.9(ients. )]TJ /T1_1 1 Tf (Acta Clin Croat)Tj /T1_0 1 Tf (. 2019 Jun;58\(2\):202\226212. )Tj 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td [(10.20471/a)-17(cc.2019.58.02.02)]TJ 0 0 0 1 k /GS1 gs 0.132 Tw -1.847 -1.25 Td (63.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(T)40(ew)]TJ /Span<>> BDC ( )Tj EMC [(GA, L)35(eight)17(on)]TJ /Span<>> BDC ( )Tj EMC [(D, Car)-24(penter)]TJ /Span<>> BDC ( )Tj EMC [(R, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. High-intensi)-23.9(t)-10(y inter)-32(v)-15(al )]TJ 0.009 Tc 0.351 Tw -1.796 -1.25 Td [(tr)-33.3(aining and moder)-33.3(a)14.7(te-intensi)-24.3(t)-10.4(y cont)-32.4(inuous tr)-33.3(aining in adul)55.7(ts)9.1( )]TJ 0.004 Tc 0.349 Tw T* [(w)0.6(i)-23.5(t)-12.5(h)0.6( C)0.5(r)-31.5(o)0.6(h)0.5(n)0.5(\245)0.6(s)0.5( d)0.5(i)0.6(s)0.5(e)0.5(a)0.6(s)0.5(e)0.5(:)0.6( a)0.6( p)0.6(i)0.5(l)30.5(o)17.6(t)0.5( r)-32.5(a)0.6(n)0.5(d)-15.5(o)0.6(m)0.5(i)0.5(s)0.6(e)0.5(d)0.6( c)0.6(o)0.5(n)0.5(t)0.6(r)-31.5(o)0.6(l)0.5(l)0.5(e)0.6(d)0.5( t)0.5(r)-36.4(i)0.5(a)0.5(l)0.6(.)0.5( )]TJ /T1_1 1 Tf -0.004 Tw [(B)0.5(M)0.6(C)4( )]TJ 0.003 Tc -0.003 Tw T* (Gastroenterol)Tj /T1_0 1 Tf 0.349 Tw [(. 2019 Jan 29;19\(1\):19. d)-15.9(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs -0.003 Tw (10.1186/s12876-019-)Tj 0 Tc 0 Tw T* (0936-x)Tj 0 0 0 1 k /GS1 gs 0.01 Tc 0.354 Tw T* [(6)0.5(4)0.6(.)]TJ /Span<>> BDC 1.324 0 Td ( )Tj EMC 0.509 0 Td [(L)70.5(y)0.6(k)0.5(o)0.5(u)0.6(r)-32.5(a)0.6(s)]TJ /Span<>> BDC 3.56 0 Td ( )Tj EMC [(D)0.6(,)0.5( K)-15.4(a)0.5(r)-23.4(k)0.5(o)0.5(u)0.6(l)-30.5(i)0.6(a)0.5(s)]TJ /Span<>> BDC 6.271 0 Td ( )Tj EMC [(K)0.6(,)0.5( T)50.5(r)-36.4(i)0.5(a)0.6(n)0.5(t)17.5(o)0.6(s)]TJ /Span<>> BDC 5.24 0 Td ( )Tj EMC [(C)0.6(.)0.5( P)0.6(h)0.5(y)-12.5(s)0.6(i)0.5(c)0.6(a)0.5(l)0.5( E)35.5(x)12.5(e)0.6(r)-31.5(c)-23.4(i)0.5(s)0.5(e)0.6( i)0.5(n)10( )]TJ 0 Tc 0.207 Tw -16.904 -1.25 Td [(P)40(a)15(t)-32(ients W)-16(i)-24(t)-13(h Infl)-16(amma)15(t)17(or)-23.9(y Bo)-14(wel Disease. )]TJ /T1_1 1 Tf (J Crohns Colitis.)Tj /T1_0 1 Tf ( 2017 )Tj 0.023 Tw T* [(A)10(ug 1;11\(8\):1024. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1093/ecco-jcc/jjx006)Tj 0 0 0 1 k /GS1 gs 0.023 Tw ( PMID: 28186528.)Tj 0.247 Tw T* (65.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(R)11(ozich)]TJ /Span<>> BDC ( )Tj EMC (JJ, Holmer)Tj /Span<>> BDC ( )Tj EMC [(A, S)-16(ingh)]TJ /Span<>> BDC ( )Tj EMC [(S. Ef)-56(fec)-15.9(t of L)-31.9(ifest)-10(yle F)20(a)-17(c)-16(t)17(or)-9.9(s on )]TJ 0.32 Tw -1.796 -1.25 Td [(Outcomes )0.5(in )0.5(P)40(a)15(t)-32(ients )0.6(W)-16(i)-24(t)-13(h )0.5(Infl)-16(amma)15.1(t)17(or)-24(y )0.5(Bo)-14(wel )0.5(Diseases. )]TJ /T1_1 1 Tf 25.387 0 Td [(Am )0.5(J )]TJ 0.024 Tc -0.024 Tw -25.387 -1.25 Td [(G)0.5(a)0.5(st)0.5(r)0.5(o)0.5(en)0.5(t)0.5(er)0.5(o)0.5(l)]TJ /T1_0 1 Tf 0.847 Tw 5.563 0 Td [(.)0.5( 2)0.5(02)0.5(0 Ju)0.5(n)0.5(;1)0.5(1)0.5(5\()0.5(6)0.5(\))0.5(:8)0.5(3)0.5(2\226)0.5(8)0.5(40)0.5(.)0.5( d)-15.5(oi)0.5(:)]TJ /Span<>> BDC 16.544 0 Td ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs -0.024 Tw [(1)0.5(0.)0.5(1)0.5(43)0.5(0)0.5(9/)]TJ 0 Tc 0 Tw -22.107 -1.25 Td (ajg.0000000000000608)Tj 0 0 0 1 k /GS1 gs 0.093 Tw T* (66.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Cr)-33(amer)]TJ /Span<>> BDC ( )Tj EMC [(H, S)-24(ch\344fer)]TJ /Span<>> BDC ( )Tj EMC [(M, S)-24(ch\366ls)]TJ /Span<>> BDC ( )Tj EMC [(M, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. R)-10(and)-16(omised cl)-31(inical tr)-37(ial: )]TJ 0.349 Tw -1.796 -1.25 Td [(yo)-16(ga vs wr)-37(i)-24(t)-30(ten self-car)-24(e ad)-17(v)-16(ice for ul)16(cer)-32.9(a)15(t)-32(i)-16(ve col)-30.9(i)-24(t)-32(is. )]TJ /T1_1 1 Tf 0 Tw (Aliment )Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\214)10(\211\036\033 \035\030\032\t\033)30(\b)42(\032)-21(\240\033\233)]TJ 57.136 0 Td (REVIEW)Tj -57.136 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 23, \023\0221)69(, 202)69(4)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 23, \023\0221)69(, 202)69(4)]TJ /T1_3 1 Tf 25 0 0 25 20.7776 56.0378 Tm (160)Tj ET endstream endobj 498 0 obj <>/Border[0 0 0]/H/N/Rect[262.057 718.512 291.968 709.056]/Subtype/Link/Type/Annot>> endobj 499 0 obj <>/Border[0 0 0]/H/N/Rect[70.8661 708.512 134.426 699.216]/Subtype/Link/Type/Annot>> endobj 500 0 obj <>/Border[0 0 0]/H/N/Rect[127.838 678.512 216.15 669.216]/Subtype/Link/Type/Annot>> endobj 501 0 obj <>/Border[0 0 0]/H/N/Rect[152.846 648.512 268.829 639.216]/Subtype/Link/Type/Annot>> endobj 502 0 obj <>/Border[0 0 0]/H/N/Rect[152.302 578.512 225.758 569.216]/Subtype/Link/Type/Annot>> endobj 503 0 obj <>/Border[0 0 0]/H/N/Rect[144.742 548.512 251.294 539.216]/Subtype/Link/Type/Annot>> endobj 504 0 obj <>/Border[0 0 0]/H/N/Rect[182.993 508.512 291.968 499.216]/Subtype/Link/Type/Annot>> endobj 505 0 obj <>/Border[0 0 0]/H/N/Rect[85.6442 478.512 159.1 469.216]/Subtype/Link/Type/Annot>> endobj 506 0 obj <>/Border[0 0 0]/H/N/Rect[260.937 448.512 291.968 439.056]/Subtype/Link/Type/Annot>> endobj 507 0 obj <>/Border[0 0 0]/H/N/Rect[70.8661 438.512 104.746 429.216]/Subtype/Link/Type/Annot>> endobj 508 0 obj <>/Border[0 0 0]/H/N/Rect[262.057 418.512 291.968 409.056]/Subtype/Link/Type/Annot>> endobj 509 0 obj <>/Border[0 0 0]/H/N/Rect[70.8661 408.512 116.354 399.216]/Subtype/Link/Type/Annot>> endobj 510 0 obj <>/Border[0 0 0]/H/N/Rect[152.966 368.512 252.269 359.216]/Subtype/Link/Type/Annot>> endobj 511 0 obj <>/Border[0 0 0]/H/N/Rect[248.721 338.512 291.968 329.056]/Subtype/Link/Type/Annot>> endobj 512 0 obj <>/Border[0 0 0]/H/N/Rect[70.8661 328.512 99.0179 319.216]/Subtype/Link/Type/Annot>> endobj 513 0 obj <>/Border[0 0 0]/H/N/Rect[85.6442 288.512 148.444 279.216]/Subtype/Link/Type/Annot>> endobj 514 0 obj <>/Border[0 0 0]/H/N/Rect[202.956 258.512 273.164 249.056]/Subtype/Link/Type/Annot>> endobj 515 0 obj <>/Border[0 0 0]/H/N/Rect[85.6442 218.512 174.908 209.216]/Subtype/Link/Type/Annot>> endobj 516 0 obj <>/Border[0 0 0]/H/N/Rect[85.6442 178.512 194.22 169.216]/Subtype/Link/Type/Annot>> endobj 517 0 obj <>/Border[0 0 0]/H/N/Rect[201.69 138.512 290.953 129.056]/Subtype/Link/Type/Annot>> endobj 518 0 obj <>/Border[0 0 0]/H/N/Rect[85.6442 98.5119 148.46 89.2159]/Subtype/Link/Type/Annot>> endobj 519 0 obj <>/Border[0 0 0]/H/N/Rect[373.796 728.512 471.267 719.216]/Subtype/Link/Type/Annot>> endobj 520 0 obj <>/Border[0 0 0]/H/N/Rect[444.17 688.512 524.409 679.056]/Subtype/Link/Type/Annot>> endobj 521 0 obj <>/Border[0 0 0]/H/N/Rect[357.023 648.512 466.191 639.216]/Subtype/Link/Type/Annot>> endobj 522 0 obj <>/Border[0 0 0]/H/N/Rect[494.498 608.512 524.409 599.056]/Subtype/Link/Type/Annot>> endobj 523 0 obj <>/Border[0 0 0]/H/N/Rect[303.307 598.512 366.867 589.216]/Subtype/Link/Type/Annot>> endobj 524 0 obj <>/Border[0 0 0]/H/N/Rect[318.085 548.512 419.58 539.216]/Subtype/Link/Type/Annot>> endobj 525 0 obj <>/Border[0 0 0]/H/N/Rect[381.407 518.512 490.119 509.216]/Subtype/Link/Type/Annot>> endobj 526 0 obj <>/Border[0 0 0]/H/N/Rect[494.498 488.512 524.409 479.056]/Subtype/Link/Type/Annot>> endobj 527 0 obj <>/Border[0 0 0]/H/N/Rect[303.307 478.512 382.107 469.216]/Subtype/Link/Type/Annot>> endobj 528 0 obj <>/Border[0 0 0]/H/N/Rect[489.898 448.512 524.409 439.056]/Subtype/Link/Type/Annot>> endobj 529 0 obj <>/Border[0 0 0]/H/N/Rect[303.307 438.512 370.138 429.216]/Subtype/Link/Type/Annot>> endobj 530 0 obj <>/Border[0 0 0]/H/N/Rect[464.186 398.512 524.409 389.056]/Subtype/Link/Type/Annot>> endobj 531 0 obj <>/Border[0 0 0]/H/N/Rect[303.307 388.512 323.331 379.216]/Subtype/Link/Type/Annot>> endobj 532 0 obj <>/Border[0 0 0]/H/N/Rect[361.279 338.512 454.303 329.216]/Subtype/Link/Type/Annot>> endobj 533 0 obj <>/Border[0 0 0]/H/N/Rect[318.085 298.512 427.061 289.216]/Subtype/Link/Type/Annot>> endobj 534 0 obj <>/Border[0 0 0]/H/N/Rect[410.939 268.512 517.003 259.216]/Subtype/Link/Type/Annot>> endobj 535 0 obj <>/Border[0 0 0]/H/N/Rect[318.085 228.512 412.301 219.216]/Subtype/Link/Type/Annot>> endobj 536 0 obj <>/Border[0 0 0]/H/N/Rect[453.337 188.512 524.409 179.056]/Subtype/Link/Type/Annot>> endobj 537 0 obj <>/Border[0 0 0]/H/N/Rect[303.307 178.512 325.675 169.216]/Subtype/Link/Type/Annot>> endobj 538 0 obj <>/Border[0 0 0]/H/N/Rect[379.825 148.512 460.065 139.216]/Subtype/Link/Type/Annot>> endobj 539 0 obj <>/Border[0 0 0]/H/N/Rect[488.991 118.512 524.409 109.056]/Subtype/Link/Type/Annot>> endobj 540 0 obj <>/Border[0 0 0]/H/N/Rect[303.307 108.512 379.611 99.2159]/Subtype/Link/Type/Annot>> endobj 583 0 obj <> endobj 582 0 obj <> endobj 581 0 obj <> endobj 580 0 obj <> endobj 579 0 obj <> endobj 578 0 obj <> endobj 577 0 obj <> endobj 576 0 obj <> endobj 575 0 obj <> endobj 574 0 obj <> endobj 573 0 obj <> endobj 572 0 obj <> endobj 571 0 obj <> endobj 570 0 obj <> endobj 569 0 obj <> endobj 568 0 obj <> endobj 567 0 obj <> endobj 566 0 obj <> endobj 565 0 obj <> endobj 564 0 obj <> endobj 563 0 obj <> endobj 562 0 obj <> endobj 561 0 obj <> endobj 560 0 obj <> endobj 559 0 obj <> endobj 558 0 obj <> endobj 557 0 obj <> endobj 556 0 obj <> endobj 555 0 obj <> endobj 554 0 obj <> endobj 553 0 obj <> endobj 552 0 obj <> endobj 551 0 obj <> endobj 550 0 obj <> endobj 549 0 obj <> endobj 548 0 obj <> endobj 547 0 obj <> endobj 546 0 obj <> endobj 545 0 obj <> endobj 544 0 obj <> endobj 543 0 obj <> endobj 542 0 obj <> endobj 541 0 obj <> endobj 494 0 obj [584 0 R 585 0 R 586 0 R 587 0 R 588 0 R 589 0 R 590 0 R 591 0 R 592 0 R 593 0 R 594 0 R 595 0 R 596 0 R 597 0 R 598 0 R 599 0 R 600 0 R 601 0 R 602 0 R 603 0 R 604 0 R 605 0 R 606 0 R 607 0 R 608 0 R 609 0 R 610 0 R 611 0 R 612 0 R 613 0 R 614 0 R 615 0 R 616 0 R 617 0 R 618 0 R 619 0 R 620 0 R 621 0 R 622 0 R 623 0 R 624 0 R] endobj 495 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\210\220\222\220\017\016\006\n\220\016 \215\221\002\013\217\001\016\001\220\ \205 \n\013\n \232\225\225\016\n)-9.9(\026\220\r\001\013\205 )]TJ 0 -1 TD [(\013\201\230\212\r\013\001\026\001\013\205 \026)11(\016\002\013\221\220\205 \221\002\220\022\002\016\024\220\006\006\220\220\ \r\025\006\221\013\007\220\026)11(\016\007\216\001\020\207 )]TJ T* [(\222\013\f\025\007\016\r\013\001\220\203 \n\220\016\017\001\220\n\013 \(\ \025\f\222\025\002 \007\220\026)11(\016\002\013\026)-19.9(\215\002\020\))]TJ 43.88 2 Td [(Ph)31(y)10(sical e)21(x)10(er)31(cises as an ef)-30.9(fectiv)12(e adju)10(v)10(ant )]TJ 2.526 -1 Td [(th)11(er)21(apy of IBD in r)31.1(emission \(r)31(e)11(vie)11(w\))]TJ /T1_1 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 42.5896 724.8299 Tm [(\r\031\024\034\033)48(\026)45(\024)-10(\223\033)48(\026/REFERENCES)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf 0.012 Tc 0.433 Tw 8 0 0 8 42.5197 711.9952 Tm (1.)Tj /Span<>> BDC ( )Tj EMC 1.331 0 Td (\207\026\022\031\035\017\027)Tj /Span<>> BDC ( )Tj EMC (\222.\206., \221\022\026\035\017\027\f\022\026\016)Tj /Span<>> BDC ( )Tj EMC (\204.\222., \221\022\026\t\r\026\036\r\026)Tj /Span<>> BDC ( )Tj EMC (\213.\200. \221\036\r\036\030\024-)Tj 0.017 Tc 0.622 Tw -1.331 -1.25 Td [(\003\026\023\026\007\027\t\005 )0.5(\030\036\020\017\f\021\030 )0.5(\023\026\006\017\036\027\021\024\r )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC 15.872 0 Td [(\r\024\f\023\026\035\017\021\036\035\034\027\t\n\017 )0.6(\026\002\024\035\036)]TJ 0 Tc 0 Tw (-)Tj 0.008 Tc 0.349 Tw -15.872 -1.25 Td (\r\026\027\017\016\n\017 \022\017\001\036\004\027\017\022\026: \007\024\f\ \021\017\032\036\027\017\016 \017)Tj /Span<>> BDC ( )Tj EMC (\031\030\024\022\017. )Tj /T1_3 1 Tf -0.008 Tw (\222\n\023\n\033\032\n\013\024\n\023\n\202\025\002.)Tj /T1_2 1 Tf 0 Tc 0 Tw 27.638 0 Td ( )Tj 0.005 Tc 0.35 Tw -27.638 -1.25 Td [(2022;21\(1\):37\22649. d)-16.2(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs -0.005 Tw (10.33878/2073-7556-2022-21-1-37-49)Tj 0 0 0 1 k /GS1 gs 0 Tc 0.355 Tw ( / )Tj 0.148 Tw 0 -1.25 TD [(Bakul)-30.9(in)]TJ /Span<>> BDC ( )Tj EMC [(I.G., S)-15.9(k)-17(al)-31(insk)-17(a)15(y)22(a)]TJ /Span<>> BDC ( )Tj EMC [(M.I., S)-16(k)-17(a)-24(zyv)-15(aev)-15(a)]TJ /Span<>> BDC ( )Tj EMC [(E.V. N)-13.9(or)-22(t)-13(h-W)22(ester)-14.9(n r)-23.9(eg)]TJ 0 Tw (-)Tj 0.194 Tw T* [(ister of )0.5(p)31.9(a)15(t)-31.9(ients wi)-24(t)-13(h infl)-15.9(amma)15(t)17(or)-24(y )0.5(bo)-14(wel diseases: a)-17(chievements )]TJ 0.059 Tw T* [(and lessons lear)-15(ned. )]TJ /T1_3 1 Tf 0 Tw [(K)17.9(olop)46.1(roktologia)]TJ /T1_2 1 Tf 0.059 Tw (. 2022;21\(1\):37\22649. \(In Russ.\). )Tj 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.33878/2073-7556-2022-21-1-37-49)Tj 0 0 0 1 k /GS1 gs -0.028 Tw -1.847 -1.25 Td (2.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (\234\036\035\t\020\017\027)Tj /Span<>> BDC ( )Tj EMC (\236.\202., \222\r\026\001\022\017\027)Tj /Span<>> BDC ( )Tj EMC (\200.\230., \207\036\035\024\031\f\024\r\026)Tj /Span<>> BDC ( )Tj EMC (\213.\202., \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. \247\r\036\027\027\t\005 )Tj 0.011 Tc 0.409 Tw -1.296 -1.25 Td (\022\024\035\017\021 \(\02551\), \r\030\024\f\035\t\036.)Tj /T1_3 1 Tf ( \222\n\023\n\033\032\n\013\024\n\023\n\202\025\002.)Tj /T1_2 1 Tf [( 2023;22\(1\):10\22644.)11( )]TJ 0.015 Tc -0.015 Tw T* [(d)-16.3(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 2.46 0 Td (10.33878/2073-7556-2023-22-1-10-44)Tj 0 0 0 1 k /GS1 gs 0.56 Tw [( )0.5(/ )0.5(S)-16.3(hel)34.7(ygin )0.5(Y)34.6(u.A.,)15( )]TJ 0 Tc 0.081 Tw -2.46 -1.25 Td [(Iv)-15(ashk)-16(in)]TJ /Span<>> BDC ( )Tj EMC [(V.T., Bel)30(ousov)-15(a)]TJ /Span<>> BDC ( )Tj EMC [(E.A., e)-11.9(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Ul)16(cer)-33(a)15(t)-32(i)-16(ve col)-31(i)-23.9(t)-32(is \(K51\), adul)56(ts. )]TJ /T1_3 1 Tf 0 Tw T* [(K)18(olop)46(roktologia)]TJ /T1_2 1 Tf 0.02 Tw [(. 2023;22\(1\):10\22644. )0.5(\(In Russ.\). )0.5(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.33878/2073-)Tj T* (7556-2023-22-1-10-44)Tj 0 0 0 1 k /GS1 gs 0.345 Tw T* (3.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(But)-30(ter)]TJ /Span<>> BDC ( )Tj EMC [(M, W)22(eiler)]TJ /Span<>> BDC ( )Tj EMC [(S, Bieder)-16(mann)]TJ /Span<>> BDC ( )Tj EMC [(L, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Cl)-31(inical manifest)15.1(a)]TJ 0 Tw (-)Tj 0.335 Tw -1.296 -1.25 Td [(t)-32(ions, )0.5(p)32(a)15(t)-13(hophy)-12.9(siol)30(o)-16(g)16(y, )0.5(tr)-24(ea)15(tment )0.5(and )0.5(outcome )0.5(of )0.5(infl)-15.9(amma)15(t)17(or)-24(y )]TJ 0.301 Tw T* [(bo)-14(wel diseases in older people. )]TJ /T1_3 1 Tf 0 Tw [(Matur)-36.9(itas)]TJ /T1_2 1 Tf 0.301 Tw [(. 2018 Ap)25(r;110:71\22678. )]TJ 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td [(10.1016/j.ma)15(tur)-36.9(i)-24(t)15(as.2018.01.015)]TJ 0 0 0 1 k /GS1 gs 0.299 Tw -1.847 -1.25 Td (4.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Bona)-24(z)]TJ /Span<>> BDC ( )Tj EMC [(BL, Ber)-15(nstein)]TJ /Span<>> BDC ( )Tj EMC [(CN. Br)-33(ain-gut inter)-33(a)-17(c)-16(t)-32(ions in infl)-16(amma)]TJ 0 Tw (-)Tj 0.011 Tc 0.404 Tw -1.296 -1.25 Td [(t)17.1(or)-23.8(y bo)-13.9(wel disease. )]TJ /T1_3 1 Tf -0.011 Tw (Gastroenterology)Tj /T1_2 1 Tf 0.404 Tw [(. 2013 Jan;144\(1\):36\22649.)11( )]TJ 0 Tc 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td [(10.1053/j.gastr)-31.9(o.2012.10.003)]TJ 0 0 0 1 k /GS1 gs 0.173 Tw -1.847 -1.25 Td (5.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Coll)-31(ins)]TJ /Span<>> BDC ( )Tj EMC [(SM. Inter)-23.9(r)-32(o)-16(ga)15(t)-32(ing t)-13(he Gut-Br)-33(ain Axis in t)-13(he Conte)-18(xt of )]TJ 0.298 Tw -1.296 -1.25 Td [(Infl)-16(amma)15.1(t)17(or)-24(y Bo)-14(wel Disease: A T)50(r)-33(ansl)-15.9(a)15(t)-32(ional App)25(r)-32(oa)-17(ch. )]TJ /T1_3 1 Tf 0 Tw [(Inf)-21.9(lamm )]TJ 0.023 Tw T* [(Bow)12(el Dis.)]TJ /T1_2 1 Tf [( 2020 Mar 4;26\(4\):493\226501. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1093/ibd/izaa004)Tj 0 0 0 1 k /GS1 gs 0.189 Tw T* (6.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(M)-24(o)-16(gilevsk)-15.9(i)]TJ /Span<>> BDC ( )Tj EMC [(T, Bur)-32(gell)]TJ /Span<>> BDC ( )Tj EMC [(R, A)-24(ziz)]TJ /Span<>> BDC ( )Tj EMC (Q, Gibson)Tj /Span<>> BDC ( )Tj EMC [(PR. R)12.9(ev)-15.9(iew ar)-22(t)-32(icle: t)-13(he )]TJ 0.29 Tw -1.296 -1.25 Td [(r)-32(ole of t)-13(he aut)17(onomic ner)-32(vous sy)-13(stem in t)-13(he p)32(a)15(t)-13(ho)-16(genesis and )]TJ 0.15 Tw T* [(t)-13(her)-33(apy of IBD. )]TJ /T1_3 1 Tf [(Aliment Phar)-14(macol Ther)]TJ /T1_2 1 Tf [(. 2019 O)-16(c)-16(t;50\(7\):720\226737. )]TJ 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1111/apt.15433)Tj 0 0 0 1 k /GS1 gs 0.032 Tw -1.847 -1.25 Td (7.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (\207\036\035\024\031\f\024\r\026)Tj /Span<>> BDC ( )Tj EMC (\213.\202., \234\036\035\t\020\017\027)Tj /Span<>> BDC ( )Tj EMC (\236.\202., \202\004\022\026\f\024\r)Tj /Span<>> BDC ( )Tj EMC (\221.\222., \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. \025\035\017\027\017\022\024-)Tj 0.347 Tw -1.296 -1.25 Td (\007\036\n\024\020\030\026\235\017\004\036\f\022\017\036 \b\026\030\026\022\ \021\036\030\017\f\021\017\022\017 \017)Tj /Span<>> BDC ( )Tj EMC (\035\036\004\036\002\027\t\005 \023\024\007\b\024\007 \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017)Tj 0 Tw (-)Tj 0.35 Tw T* (\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\r\024\f\023\026\035\017\021\036\035\034\027\t\n\017 \026\002\024\035\036\ \r\026\027\017\016\n\017 \022\017\001\036\004\027\017\022\026 \(\002\024\ \035\036\027\034 )Tj 0.012 Tc 0.43 Tw T* (\025\030\024\027\026, \016\r\036\027\027\t\005 \022\024\035\017\021\) \r\ )Tj /Span<>> BDC ( )Tj EMC [(\217\205. \215\036\030\r\t\036 \030\036\031\035\034\021\026\021\t \026\027\ \026\035\017\026)12( )]TJ 0.004 Tc 0.35 Tw T* (\027\026\006\017\024\027\026\035\034\027\024\020\024 \217\036\020\017\f\021\ \030\026. )Tj /T1_3 1 Tf -0.004 Tw (\222\n\023\n\033\032\n\013\024\n\023\n\202\025\002.)Tj /T1_2 1 Tf 0.35 Tw [( 2023;22\(1\):65\22682.)4( )]TJ 0.015 Tc -0.015 Tw T* [(d)-15.5(o)0.5(i)0.5(:)]TJ /Span<>> BDC 1.649 0 Td ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0.778 0 Td [(1)0.5(0)0.5(.)0.5(3)0.5(3)0.5(8)0.5(7)0.5(8)0.5(/)0.5(2)0.5(0)0.5(7)0.5(3)0.5(-)0.5(7)0.5(5)0.5(5)0.5(6)0.5(-)0.5(2)0.5(0)0.5(2)0.5(3)0.5(-)0.5(2)0.5(2)0.5(-)0.5(1)0.5(-)0.5(6)0.5(5)0.5(-)0.5(8)0.5(2)]TJ 0 0 0 1 k /GS1 gs 0.531 Tw 16.344 0 Td [( )0.5(/)0.5( )0.6(B)0.5(e)0.5(l)30.5(o)0.5(u)0.5(s)0.5(o)0.5(v)-14.5(a)]TJ /Span<>> BDC 6.216 0 Td ( )Tj EMC 0.778 0 Td [(E)0.5(.)0.5(A)0.5(.)0.5(,)15( )]TJ 0.004 Tc 0.349 Tw -25.766 -1.25 Td [(S)-15.4(h)0.5(e)0.6(l)35.5(y)0.6(g)0.5(i)0.6(n)0.5( Y)35.6(u)0.5(.)0.6(A)0.5(.)0.6(,)0.5( A)-24.4(c)0.5(h)0.6(k)-16.4(a)0.5(s)0.6(o)0.5(v)]TJ /Span<>> BDC 10.77 0 Td ( )Tj EMC [(S)0.5(.)0.6(I)0.5(.)0.6(,)0.6( e)-11.4(t)]TJ /Span<>> BDC 3.641 0 Td ( )Tj EMC [(a)0.5(l)0.6(.)0.6( C)0.6(l)-30.5(i)0.6(n)0.6(i)0.5(c)0.6(a)0.5(l)0.6( a)0.5(n)0.6(d)0.5( D)0.5(e)0.6(m)0.5(o)-15.4(g)0.6(r)-32.5(a)0.6(p)0.5(h)0.6(i)0.5(c)4( )]TJ 0 Tc -0.003 Tw -14.411 -1.25 Td [(F)10(ea)15(tur)-24(es and T)50(r)-24(ea)15(tment App)25(r)-32(oa)-17(ches for Infl)-16(amma)15.1(t)17(or)-24(y Bo)-14(wel Diseases )]TJ 0.336 Tw T* [(\(Cr)-32(ohn\245s Disease, Ul)16(cer)-33(a)15(t)-32(i)-16(ve Col)-31(i)-23.9(t)-32(is\) in t)-13(he Russia. T)47(he P)35(r)-37(imer)-23.9(y )]TJ 0.234 Tw T* [(R)13(esul)56(ts of t)-12.9(he Anal)35(y)-13(sis of t)-13(he Na)15.1(t)-32(ional R)13(egister. )]TJ /T1_3 1 Tf 0 Tw [(K)18(olop)46(roktologia)]TJ /T1_2 1 Tf (. )Tj 0.18 Tw T* [(2023;22\(1\):65\22682. \(In Russ.\). d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.33878/2073-7556-2023-22-)Tj T* (1-65-82)Tj 0 0 0 1 k /GS1 gs 0.249 Tw T* (8.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (\216\026\035\017\235)Tj /Span<>> BDC ( )Tj EMC 3.084 0 Td [(\222.\214., )0.5(\234\026\023\017\027\026)]TJ /Span<>> BDC ( )Tj EMC 6.221 0 Td [(\204.\200., )0.5(\206\024\035\024\r\036\027\022\024)]TJ /Span<>> BDC ( )Tj EMC 7.276 0 Td [(\202.\210., )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 3.368 0 Td [(\f\024\026\r\021. )0.5(\230\036\004\036\027\017\036 )]TJ -0.017 Tw -21.245 -1.25 Td (\b\030\024\027\017\004\036\f\022\017\b \r\024\f\023\026\035\017\021\036\035\ \034\027\t\b \026\002\024\035\036\r\026\027\017\005 \022\017\001\036\004\ \027\017\022\026 \017)Tj /Span<>> BDC ( )Tj EMC (\n\036\021\024\007\t \017\b )Tj 0.037 Tw T* (\035\036\004\036\027\017\016, \023\030\017\n\036\027\016\036\n\t\036 \r)Tj /Span<>> BDC ( )Tj EMC (\217\024\f\f\017\005\f\022\024\005 \205\036\007\036\030\026\006\017\017 \ \(\217\036\031\035\034\021\026\021\t \n\027\024)Tj 0 Tw (-)Tj 0.142 Tw T* (\020\024\006\036\027\021\030\024\r\024\020\024 \023\024\023\031\035\016\006\ \017\024\027\027\024\020\024 \024\007\027\024\n\024\n\036\027\021\027\024\ \020\024 \027\026\002\035\033\007\026\021\036\035\034\027\024\020\024 )Tj 0 Tw T* (\017\f\f\035\036\007\024\r\026\027\017\016\). )Tj /T1_3 1 Tf 0.185 Tw 6.851 0 Td (\212\n\t\t\025\017\t\013\025\017 \204\205\032\021\026\023 \202\026\t\024\ \032\n\r\021\024\031\032\n\023\n\202\025\025, \202\031\033\026\024\n)Tj 0 Tw (-)Tj 0.15 Tw -6.851 -1.25 Td (\023\n\202\025\025, \013\n\023\n\033\032\n\013\024\n\023\n\202\025\025.)Tj /T1_2 1 Tf [( 2018;28\(3\):54\22662. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.22416/1382-)Tj T* (4376-2018-28-3-54-62)Tj 0 0 0 1 k /GS1 gs 0.161 Tw [( / Khal)-30.9(if)]TJ /Span<>> BDC ( )Tj EMC [(I.L., S)-16(hapina)]TJ /Span<>> BDC ( )Tj EMC [(M.V., Gol)30(ovenko)]TJ /Span<>> BDC ( )Tj EMC (A.O., )Tj 0.164 Tw T* [(e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Chr)-32(onic infl)-15.9(amma)15(t)17(or)-24(y bo)-14(wel diseases: t)-12.9(he cour)-10(se and tr)-23.9(ea)15(t)]TJ 0 Tw (-)Tj 0.187 Tw T* [(ment me)-12(t)-13(hods in Russian F)10(eder)-33(a)15(t)-32(ion \(R)13(esul)56(ts of mul)56.1(t)-32(icenter pop)]TJ 0 Tw (-)Tj 0.253 Tw T* [(ul)-16(a)15(t)-32(ion-based one-st)15.1(a)-17(ge obser)-32(v)-15(a)15.1(t)-32(ional stud)17.1(y\). )]TJ /T1_3 1 Tf [(R)22(ussian Jour)-13.9(nal of )]TJ 0.061 Tw T* [(Gastroenterology, Hepatology, Colop)46.1(roctology.)]TJ /T1_2 1 Tf ( 2018;28\(3\):54\22662. \(In )Tj 0.023 Tw T* [(Russ.\). d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.22416/1382-4376-2018-28-3-54-62)Tj 0 0 0 1 k /GS1 gs 0.007 Tw T* (9.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Dav)-16(is)]TJ /Span<>> BDC ( )Tj EMC [(SP, )0.5(Cr)-33(ane)]TJ /Span<>> BDC ( )Tj EMC [(PB, Bol)-31(in)]TJ /Span<>> BDC ( )Tj EMC [(LP, )0.5(e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. An integr)-33(a)15.1(t)-32(i)-16(ve r)-24(ev)-15.9(iew of phy)-13(si)]TJ 0 Tw (-)Tj 0.14 Tw -1.296 -1.25 Td [(cal a)-17(c)-16(t)-31.9(i)-16(v)-16(i)-24(t)-10(y )0.5(in adul)56(ts wi)-23.9(t)-13(h infl)-16(amma)15.1(t)17(or)-24(y bo)-14(wel )0.5(disease)]TJ /T1_3 1 Tf [(. Intest )0.5(R)21(es.)]TJ /T1_2 1 Tf 0 Tw ( )Tj 0.023 Tw T* [(2022 Jan;20\(1\):43\22652. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.5217/ir.2020.00049)Tj 0 0 0 1 k /GS1 gs 0.285 Tw T* (10.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(F)10(or)-22(te)]TJ /Span<>> BDC ( )Tj EMC [(P, Br)-33(anquinho)]TJ /Span<>> BDC ( )Tj EMC [(L, F)10(er)-24(r)-33(a)-24(z)]TJ /Span<>> BDC ( )Tj EMC [(R. T)47(he R)13(el)-16(a)15.1(t)-32(ionships be)-12(t)-32(ween )]TJ 0.097 Tw -1.796 -1.25 Td [(Phy)-13(sical A)-24.9(c)-16(t)-32(i)-16(v)-16(i)-23.9(t)-10(y, E)35.1(x)12(er)-32(c)-24(ise, and Spor)-22(t on t)-12.9(he Immune Sy)-13(stem. )]TJ /T1_3 1 Tf (Int J )Tj 0.161 Tw T* [(En)11(viron R)21(es Public Health.)]TJ /T1_2 1 Tf [( 2022 Jun 1;19\(11\):6777. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.3390/)Tj T* [(ijer)-23.9(ph19116777)]TJ 0 0 0 1 k /GS1 gs 0.01 Tc 0.357 Tw T* [(11)0.5(.)]TJ /Span<>> BDC 1.325 0 Td ( )Tj EMC 0.51 0 Td [(P)30.4(e)-11.5(t)0.5(er)-9.5(s)0.5(en)]TJ /Span<>> BDC 3.555 0 Td ( )Tj EMC [(A)0.5(MW)0.5(, P)30.4(e)0.5(de)0.5(r)-9.6(s)0.5(e)0.5(n)]TJ /Span<>> BDC ( )Tj EMC [(B)0.5(K.)0.5( T)47.5(he)0.5( an)0.5(t)-31.6(i)0.5(-)0.5(in)0.5(fl)-15.5(a)0.5(mm)0.5(a)15.4(t)17.5(or)-23.5(y)0.5( ef)-55.5(f)0.5(ec)-15.5(t)10( )]TJ 0.011 Tc 0.396 Tw -5.389 -1.25 Td [(of e)-17.6(x)12.4(er)-31.6(c)-23.6(ise. )]TJ /T1_3 1 Tf [(J Appl Ph)12.4(ysiol \(1985\).)]TJ /T1_2 1 Tf [( 2005 )0.5(Ap)25.4(r;98\(4\):1154\22662.)11( )]TJ 0 Tc 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td [(10.1152/japplphy)-12.9(siol.00164.2004)]TJ 0 0 0 1 k /GS1 gs 0.308 Tw -1.847 -1.25 Td (12.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (McDaniel)Tj /Span<>> BDC ( )Tj EMC (DK, Eden)Tj /Span<>> BDC ( )Tj EMC [(K, R)-23.9(ingel)]TJ /Span<>> BDC ( )Tj EMC [(VM, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Emer)-32(ging R)10.9(oles for )]TJ 0.17 Tw -1.796 -1.25 Td [(N)-14(oncanonical )0.6(NF-\264B )0.6(S)-16(ignal)-31(ing )0.6(in )0.5(t)-12.9(he )0.5(M)-24(odul)-15.9(a)15(t)-32(ion )0.5(of )0.6(Infl)-16(amma)15(t)17.1(or)-24(y )]TJ 0.023 Tc 0.829 Tw 29.055 78.75 Td [(Bo)-14(wel )0.5(Disease )0.5(P)40(a)15(t)-13(hobiol)30(o)-16(g)15.9(y. )]TJ /T1_3 1 Tf 14.806 0 Td [(Inf)-22(lamm )0.5(Bow)12(el )0.5(Dis.)]TJ /T1_2 1 Tf [( )0.5(2016)23( )]TJ 0 Tc 0.023 Tw -14.806 -1.25 Td [(Sep;22\(9\):2265\22679. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1097/MIB.0000000000000858)Tj 0 0 0 1 k /GS1 gs 0.214 Tw T* (13.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Ell)-31(ingsgaar)-23.9(d)]TJ /Span<>> BDC ( )Tj EMC (H, Hauselmann)Tj /Span<>> BDC ( )Tj EMC [(I, S)-24(chuler)]TJ /Span<>> BDC ( )Tj EMC [(B, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Inter)-29.9(leuk)-16(in-6 )]TJ 0.012 Tc 0.453 Tw -1.796 -1.25 Td [(enhances )0.6(insul)-31.3(in )0.5(secr)-24.2(e)-12.2(t)-32.3(ion )0.5(b)11.8(y )0.5(incr)-24.3(easing )0.5(gl)34.7(uca)-17.3(gon-l)-31.2(ik)9.8(e )0.5(pep)]TJ 0 Tc 0 Tw (-)Tj 0.205 Tw T* [(t)-32(ide-1 )0.5(secr)-24(e)-12(t)-32(ion )0.5(fr)-32(om )0.5(L cells )0.5(and )0.5(alpha cells. )]TJ /T1_3 1 Tf 19.708 0 Td [(N)18(at )0.5(Med.)]TJ /T1_2 1 Tf [( 2011 )0.5(O)-16(c)-16(t )]TJ 0.023 Tw -19.708 -1.25 Td [(30;17\(11\):1481\2269. d)-15.9(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1038/nm.2513)Tj 0 0 0 1 k /GS1 gs 0.04 Tw T* (14.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Ma)15(t)-13(hur)]TJ /Span<>> BDC ( )Tj EMC [(N, P)30(eder)-9.9(sen)]TJ /Span<>> BDC ( )Tj EMC [(BK. E)35(x)12(er)-32(c)-24(ise as a mean t)17(o contr)-31.9(ol l)30(o)-14(w-gr)-33(ade )]TJ 0.01 Tc 0.384 Tw -1.796 -1.25 Td [(sy)-13.3(stemic infl)-16.3(amma)14.7(t)-32.3(ion. )]TJ /T1_3 1 Tf [(Mediators Inf)-22.3(lamm.)]TJ /T1_2 1 Tf [( 2008;2008:109502.)10( )]TJ 0 Tc 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1155/2008/109502)Tj 0 0 0 1 k /GS1 gs 0.037 Tw -1.847 -1.25 Td (15.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(L)-32(ancaster)]TJ /Span<>> BDC ( )Tj EMC [(GI, F)10(ebbr)-33(aio)]TJ /Span<>> BDC ( )Tj EMC [(MA. T)47(he immunomodul)-15.9(a)15(t)-32(ing r)-32(ole of e)-18(x)12(er)]TJ 0 Tw 25.49 0 Td (-)Tj 0.126 Tw -27.286 -1.25 Td [(c)-24(ise in me)-12(t)15(abol)-31(ic disease. )]TJ /T1_3 1 Tf [(T)56.1(rends Immunol.)]TJ /T1_2 1 Tf ( 2014 Jun;35\(6\):262\2269. )Tj 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td [(10.1016/j.i)-23.9(t.2014.02.008)]TJ 0 0 0 1 k /GS1 gs 0.114 Tw -1.847 -1.25 Td (16.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Engels)Tj /Span<>> BDC ( )Tj EMC [(M, Cr)-32(oss)]TJ /Span<>> BDC ( )Tj EMC [(RK, L)35(ong)]TJ /Span<>> BDC ( )Tj EMC [(MD. E)35(x)12(er)-32(c)-23.9(ise in p)32.1(a)14.9(t)-31.9(ients wi)-24(t)-13(h infl)-15.9(am)]TJ 0 Tw (-)Tj 0.071 Tw -1.796 -1.25 Td [(ma)15(t)17(or)-24(y bo)-14(wel )0.5(diseases: cur)-24(r)-23.9(ent per)-10(spec)-16(t)-32(i)-16(ves. )]TJ /T1_3 1 Tf 18.666 0 Td (Clin Exp Gastroenterol.)Tj /T1_2 1 Tf 0 Tw ( )Tj 0.023 Tw -18.666 -1.25 Td [(2017 Dec 22;11:1\22611. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.2147/CEG.S120816)Tj 0 0 0 1 k /GS1 gs 0.12 Tw T* (17.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Neur)-33(a)15.1(t)-13(h)]TJ /Span<>> BDC ( )Tj EMC [(MF. Cy)-15.9(t)17(ok)-16(ines in infl)-16(amma)15(t)17(or)-23.9(y bo)-14(wel disease. )]TJ /T1_3 1 Tf [(N)18(at R)21.1(ev )]TJ 0 Tw -1.796 -1.25 Td (Immunol)Tj /T1_2 1 Tf 0.023 Tw [(. 2014 Ma)15(y;14\(5\):329\22642. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw [(10.1038/nr)-37(i3661)]TJ 0 0 0 1 k /GS1 gs 0.18 Tw T* (18.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Bilsk)-15.9(i, Ma)-24(zur-Bial)35.1(y)]TJ /Span<>> BDC ( )Tj EMC [(A, Br)-24(zozo)-13.9(wsk)-16(i)]TJ /Span<>> BDC ( )Tj EMC [(B, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC 16.389 0 Td [(al. Can )0.5(e)-18(x)12(er)-32(c)-24(ise af)-56(fec)-15.9(t )]TJ 0.02 Tw -18.185 -1.25 Td [(t)-13(he cour)-9.9(se of infl)-16(amma)15.1(t)17(or)-24(y bo)-14(wel disease? E)35(xper)-37(iment)15.1(al and cl)-31(inical )]TJ 0 Tw T* [(ev)-16(idence. )]TJ /T1_3 1 Tf 0.136 Tw 4.26 0 Td [(Phar)-14(macol )0.5(R)21(ep.)]TJ /T1_2 1 Tf [( )0.5(2016 )0.5(A)10(ug;68\(4\):827\22636. )0.5(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw 19.063 0 Td (10.1016/j.)Tj -23.324 -1.25 Td [(phar)-24(ep.2016.04.009)]TJ 0 0 0 1 k /GS1 gs -0.034 Tw T* (19.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(P)30(eder)-10(sen)]TJ /Span<>> BDC ( )Tj EMC [(BK. Spec)-23.9(ial fea)15(tur)-24(e for t)-13(he Ol)35(ym)10(pics: ef)-56(fec)-15.9(ts of e)-17.9(x)12(er)-32(c)-24(ise )]TJ 0.131 Tw -1.796 -1.25 Td [(on t)-12.9(he immune sy)-13(stem: e)-18(x)12(er)-32(c)-24(ise and cy)-15.9(t)17(ok)-16(ines. )]TJ /T1_3 1 Tf (Immunol Cell Biol.)Tj /T1_2 1 Tf 0 Tw ( )Tj 0.023 Tw T* [(2000 O)-16(c)-16(t;78\(5\):532\2265. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1111/j.1440-1711.2000.t01-11-.x)Tj 0 0 0 1 k /GS1 gs 0.12 Tw T* (20.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Gleeson)Tj /Span<>> BDC ( )Tj EMC (M, Bishop)Tj /Span<>> BDC ( )Tj EMC [(NC, S)15(tensel)]TJ /Span<>> BDC ( )Tj EMC [(DJ, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. T)47(he ant)-32(i-infl)-15.9(amma)15(t)17(or)-23.9(y )]TJ 0.034 Tw -1.796 -1.25 Td [(ef)-56(fec)-16(ts of e)-18(x)12(er)-32(c)-24(ise: mechanis)26(ms and im)10.1(pl)-30.9(ica)15(t)-32(ions for t)-12.9(he p)25(r)-24(event)-31.9(ion )]TJ 0.054 Tw T* [(and tr)-23.9(ea)15(tment of disease. )]TJ /T1_3 1 Tf [(N)18(at R)21(ev Immunol.)]TJ /T1_2 1 Tf [( 2011 A)10(ug 5;11\(9\):607\226)]TJ 0.023 Tw T* [(15. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw [(10.1038/nr)-37(i3041)]TJ 0 0 0 1 k /GS1 gs 0.131 Tw T* (21.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(S)15(teensber)-31.9(g)]TJ /Span<>> BDC ( )Tj EMC [(A, )0.5(F)-19(ischer)]TJ /Span<>> BDC ( )Tj EMC 9.136 0 Td [(CP, )0.5(K)25(eller)]TJ /Span<>> BDC ( )Tj EMC 4.15 0 Td [(C, )0.5(e)-12(t)]TJ /Span<>> BDC ( )Tj EMC 2.21 0 Td [(al. )0.5(IL-6 )0.5(enhances )0.5(pl)-15.9(as)26(ma )]TJ 0.014 Tw -17.292 -1.25 Td [(IL-1r)-32.9(a, IL-10, and cor)-21.9(t)-32(isol in humans. )]TJ /T1_3 1 Tf [(Am J Ph)12(ysiol Endocr)-37(inol Metab.)]TJ /T1_2 1 Tf 0 Tw ( )Tj 0.023 Tw T* [(2003 A)10(ug;285\(2\):E433\2267. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw [(10.1152/ajpend)-15.9(o.00074.2003)]TJ 0 0 0 1 k /GS1 gs 0.03 Tw T* (22.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(P)30(eder)-10(sen)]TJ /Span<>> BDC ( )Tj EMC [(BK, Sal)56.1(t)-32(in)]TJ /Span<>> BDC ( )Tj EMC [(B. E)35(x)12(er)-32(c)-24(ise as medic)-24(ine)]TJ /Span<>> BDC ( )Tj EMC [(\227 ev)-16(idence for p)25(r)-24(e)]TJ 0 Tw (-)Tj -0.008 Tw -1.796 -1.25 Td [(scr)-37(ibing e)-18(x)12.1(er)-32(c)-24(ise as t)-13(her)-33(apy in 26 dif)-56(fer)-23.9(ent chr)-32(onic diseases. )]TJ /T1_3 1 Tf (Scand J )Tj 0.023 Tw T* [(Med Sci Spor)-40(ts)]TJ /T1_2 1 Tf [(. 2015 Dec;25 Suppl 3:1\22672. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw [(10.1111/s)26(ms.12581)]TJ 0 0 0 1 k /GS1 gs 0.15 Tw T* (23.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Cullen)Tj /Span<>> BDC ( )Tj EMC [(T, T)47(homas)]TJ /Span<>> BDC ( )Tj EMC [(A)27(W, W)22(ebb)]TJ /Span<>> BDC ( )Tj EMC [(R, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Inter)-30(leuk)-15.9(in-6 and asso)-16(c)-24(i)]TJ 0 Tw (-)Tj 0.072 Tw -1.796 -1.25 Td [(a)15(ted cy)-16(t)17(ok)-15.9(ine r)-24(esponses t)17(o an a)-17(cute bout of high-intensi)-23.9(t)-10(y inter)-32(v)-14.9(al )]TJ 0.13 Tw T* [(e)-18(x)12(er)-31.9(c)-24(ise: t)-13(he )0.5(ef)-56(fec)-16(t of )0.5(e)-18(x)12(er)-32(c)-24(ise )0.5(intensi)-24(t)-10(y )0.5(and vol)35(ume. )]TJ /T1_3 1 Tf 22.728 0 Td [(Appl Ph)12(ysiol )]TJ 0.023 Tw -22.728 -1.25 Td [(N)21(utr Metab)]TJ /T1_2 1 Tf [(. 2016 A)10(ug;41\(8\):803\2268. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1139/apnm-2015-0640)Tj 0 0 0 1 k /GS1 gs 0.272 Tw T* (24.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Sax)12(ena)]TJ /Span<>> BDC ( )Tj EMC [(A, Fle)-12(tcher)]TJ /Span<>> BDC ( )Tj EMC [(E, L)-32(ar)-10(sen)]TJ /Span<>> BDC ( )Tj EMC [(B, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Ef)-56(fec)-16(t of e)-18(x)12(er)-32(c)-24(ise on )]TJ 0.04 Tw -1.796 -1.25 Td [(chemicall)35.1(y-induced col)-31(i)-24(t)-32(is in adiponec)-16(t)-32(in def)-28(ic)-24(ient mice. )]TJ /T1_3 1 Tf [(J Inf)-22(lamm )]TJ 0 Tw T* (\(Lond\))Tj /T1_2 1 Tf 0.023 Tw [(. 2012 A)10(ug 21;9\(1\):30. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1186/1476-9255-9-30)Tj 0 0 0 1 k /GS1 gs 0.099 Tw T* (25.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Bilsk)-15.9(i)]TJ /Span<>> BDC ( )Tj EMC [(J, Ma)-24(zur-Bial)35.1(y)]TJ /Span<>> BDC ( )Tj EMC [(AI, Br)-24(zozo)-13.9(wsk)-16(i)]TJ /Span<>> BDC ( )Tj EMC [(B, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. M)-23.9(oder)-33(a)15(te e)-18(x)12(er)-32(c)-23.9(ise )]TJ 0.071 Tw -1.796 -1.25 Td [(tr)-33(aining a)15(t)-30(tenua)15(tes t)-13(he sever)-37(i)-24(t)-9.9(y of e)-18(xper)-37(iment)15(al r)-32(odent col)-31(i)-24(t)-32(is: t)-13(he )]TJ -0.023 Tw T* [(im)10(por)-22(t)15.1(ance of cr)-32(osst)15(alk be)-12(t)-32(ween adipose t)-32(issue and sk)10(ele)-11.9(t)15(al muscles. )]TJ /T1_3 1 Tf 0.023 Tw T* [(Mediators Inf)-22(lamm)]TJ /T1_2 1 Tf [(. 2015;2015:605071. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1155/2015/605071)Tj 0 0 0 1 k /GS1 gs 0.12 Tw T* (26.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Neur)-33(a)15.1(t)-13(h)]TJ /Span<>> BDC ( )Tj EMC [(MF. Cy)-15.9(t)17(ok)-16(ines in infl)-16(amma)15(t)17(or)-23.9(y bo)-14(wel disease. )]TJ /T1_3 1 Tf [(N)18(at R)21.1(ev )]TJ 0 Tw -1.796 -1.25 Td (Immunol.)Tj /T1_2 1 Tf 0.023 Tw [( 2014 Ma)15(y;14\(5\):329\22642. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw [(10.1038/nr)-37(i3661)]TJ 0 0 0 1 k /GS1 gs 0.344 Tw T* (27.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Allen)Tj /Span<>> BDC ( )Tj EMC 2.634 0 Td [(J, )0.5(Sun)]TJ /Span<>> BDC ( )Tj EMC 3.289 0 Td [(Y, )0.5(W)20(o)-16(ods)]TJ /Span<>> BDC ( )Tj EMC 4.408 0 Td [(J)15(A. )0.5(E)35(x)12(er)-32(c)-23.9(ise )0.5(and )0.5(t)-13(he )0.5(R)13(egul)-16(a)15(t)-32(ion )0.5(of )]TJ 0.037 Tw -12.127 -1.25 Td [(Infl)-15.9(amma)15(t)17(or)-24(y R)13(esponses. )]TJ /T1_3 1 Tf [(Prog Mol Biol T)56(ransl Sci)]TJ /T1_2 1 Tf (. 2015;135:337\22654. )Tj 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td [(10.1016/bs.pmb)16(ts.2015.07.003)]TJ 0 0 0 1 k /GS1 gs 0.003 Tw -1.847 -1.25 Td (28.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Pl)30(oeger)]TJ /Span<>> BDC ( )Tj EMC (H, Obeid)Tj /Span<>> BDC ( )Tj EMC (J, Nguyen)Tj /Span<>> BDC ( )Tj EMC [(T, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. E)35(x)12(er)-32(c)-24(ise and infl)-16(amma)15.1(t)-32(ion in )]TJ 0.096 Tw -1.796 -1.25 Td [(pedia)15(tr)-36.9(ic Cr)-32(ohn\245s disease. )]TJ /T1_3 1 Tf [(Int J Spor)-39.9(ts Med.)]TJ /T1_2 1 Tf [( 2012 A)10(ug;33\(8\):671\2269. )]TJ 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1055/s-0032-1304323)Tj 0 0 0 1 k /GS1 gs -0.017 Tw -1.847 -1.25 Td (29.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Dor)-15(neles)]TJ /Span<>> BDC ( )Tj EMC [(GP, Hadd)42(ad)]TJ /Span<>> BDC ( )Tj EMC [(DO, F)19.9(a)-16.9(gundes)]TJ /Span<>> BDC ( )Tj EMC [(VO, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. High intensi)-23.9(t)-10(y inter)]TJ 0 Tw 25.49 0 Td (-)Tj 0.209 Tw -27.286 -1.25 Td [(v)-15(al )0.6(e)-18(x)12(er)-32(c)-24(ise )0.6(decr)-24(eases )0.6(IL-8 )0.6(and )0.5(enhances )0.5(t)-13(he )0.6(immunomodul)-15.9(a)15(t)17(or)-24(y )]TJ 0.172 Tw T* [(cy)-16(t)17(ok)-15.9(ine inter)-29.9(leuk)-16(in-10 )0.5(in )0.5(lean )0.5(and over)-37.9(weight-obese )0.5(indi)-16(v)-16(iduals. )]TJ /T1_3 1 Tf 0 Tw T* (Cytokine)Tj /T1_2 1 Tf 0.023 Tw [(. 2016 Jan;77:1\2269. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw [(10.1016/j.cy)-16(t)17(o.2015.10.003)]TJ 0 0 0 1 k /GS1 gs 0.31 Tw T* (30.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Bak)10(er)]TJ /Span<>> BDC ( )Tj EMC (KA, Miller)Tj /Span<>> BDC ( )Tj EMC [(TD, Mar)-36.9(ino)]TJ /Span<>> BDC ( )Tj EMC [(FE, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. T)47(he e)-18(x)12(er)-32(c)-24(ise-induced )]TJ 0.06 Tw -1.796 -1.25 Td [(infl)-15.9(amma)15(t)17(or)-24(y r)-24(esponse in infl)-16(amma)15.1(t)17(or)-24(y bo)-14(wel disease: A sy)-13(stema)15.1(t)-32(ic )]TJ 0.199 Tw T* [(r)-24(ev)-15.9(iew and me)-11.9(t)15(a-anal)35(y)-13(sis. )]TJ /T1_3 1 Tf (PLoS One.)Tj /T1_2 1 Tf [( 2022 F)10(eb 4;17\(2\):e0262534. )]TJ 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td [(10.1371/jour)-14.9(nal.pone.0262534)]TJ 0 0 0 1 k /GS1 gs 0.155 Tw -1.847 -1.25 Td (31.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(R)11(o)-16(gler)]TJ /Span<>> BDC ( )Tj EMC [(G, Bieder)-16(mann)]TJ /Span<>> BDC ( )Tj EMC [(L. Cl)-30.9(inical Ut)-31.9(il)-31(i)-24(t)-10(y of Biomar)-24(k)10(er)-10(s in IBD. )]TJ /T1_3 1 Tf 0.293 Tw -1.796 -1.25 Td [(Cur)-16(r )0.5(Gastroenterol )0.5(R)21(ep.)]TJ /T1_2 1 Tf [( )0.5(2015 )0.5(Jul;17\(7\):26. )0.5(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw 20.658 0 Td (10.1007/s11894-)Tj -20.658 -1.25 Td (015-0449-x)Tj /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\214)10(\211\036\033 \035\030\032\t\033)30(\b)42(\032)-21(\240\033\233)]TJ 57.136 0 Td (REVIEW)Tj /T1_4 1 Tf 25 0 0 25 505.4521 56.0378 Tm (159)Tj ET endstream endobj 584 0 obj <>/Border[0 0 0]/H/N/Rect[127.131 689.291 255.376 679.995]/Subtype/Link/Type/Annot>> endobj 585 0 obj <>/Border[0 0 0]/H/N/Rect[57.2978 649.291 184.105 639.995]/Subtype/Link/Type/Annot>> endobj 586 0 obj <>/Border[0 0 0]/H/N/Rect[62.1972 619.291 193.169 609.995]/Subtype/Link/Type/Annot>> endobj 587 0 obj <>/Border[0 0 0]/H/N/Rect[210.894 599.291 263.622 589.835]/Subtype/Link/Type/Annot>> endobj 588 0 obj <>/Border[0 0 0]/H/N/Rect[42.5197 589.291 116.599 579.995]/Subtype/Link/Type/Annot>> endobj 589 0 obj <>/Border[0 0 0]/H/N/Rect[57.2978 549.291 165.976 539.995]/Subtype/Link/Type/Annot>> endobj 590 0 obj <>/Border[0 0 0]/H/N/Rect[57.2978 519.291 155.321 509.995]/Subtype/Link/Type/Annot>> endobj 591 0 obj <>/Border[0 0 0]/H/N/Rect[182.996 489.291 251.676 479.835]/Subtype/Link/Type/Annot>> endobj 592 0 obj <>/Border[0 0 0]/H/N/Rect[57.2978 449.291 120.113 439.995]/Subtype/Link/Type/Annot>> endobj 593 0 obj <>/Border[0 0 0]/H/N/Rect[61.9393 389.291 192.691 379.995]/Subtype/Link/Type/Annot>> endobj 594 0 obj <>/Border[0 0 0]/H/N/Rect[162.447 339.291 263.622 329.995]/Subtype/Link/Type/Annot>> endobj 595 0 obj <>/Border[0 0 0]/H/N/Rect[42.5197 329.291 68.1515 319.995]/Subtype/Link/Type/Annot>> endobj 596 0 obj <>/Border[0 0 0]/H/N/Rect[210.894 269.291 263.622 259.835]/Subtype/Link/Type/Annot>> endobj 597 0 obj <>/Border[0 0 0]/H/N/Rect[42.5197 259.291 116.599 249.995]/Subtype/Link/Type/Annot>> endobj 598 0 obj <>/Border[0 0 0]/H/N/Rect[81.6276 209.291 208.435 199.995]/Subtype/Link/Type/Annot>> endobj 599 0 obj <>/Border[0 0 0]/H/N/Rect[134.454 179.291 209.853 169.995]/Subtype/Link/Type/Annot>> endobj 600 0 obj <>/Border[0 0 0]/H/N/Rect[233.71 149.291 263.622 139.835]/Subtype/Link/Type/Annot>> endobj 601 0 obj <>/Border[0 0 0]/H/N/Rect[42.5197 139.291 93.5993 129.995]/Subtype/Link/Type/Annot>> endobj 602 0 obj <>/Border[0 0 0]/H/N/Rect[57.2978 109.291 167.233 99.9952]/Subtype/Link/Type/Annot>> endobj 603 0 obj <>/Border[0 0 0]/H/N/Rect[356.837 709.291 465.812 699.995]/Subtype/Link/Type/Annot>> endobj 604 0 obj <>/Border[0 0 0]/H/N/Rect[353.381 669.291 411.58 659.995]/Subtype/Link/Type/Annot>> endobj 605 0 obj <>/Border[0 0 0]/H/N/Rect[289.739 639.291 363.195 629.995]/Subtype/Link/Type/Annot>> endobj 606 0 obj <>/Border[0 0 0]/H/N/Rect[289.739 609.291 372.594 599.995]/Subtype/Link/Type/Annot>> endobj 607 0 obj <>/Border[0 0 0]/H/N/Rect[363.241 579.291 435.121 569.995]/Subtype/Link/Type/Annot>> endobj 608 0 obj <>/Border[0 0 0]/H/N/Rect[404.456 559.291 459.568 549.835]/Subtype/Link/Type/Annot>> endobj 609 0 obj <>/Border[0 0 0]/H/N/Rect[461.551 529.291 496.063 519.835]/Subtype/Link/Type/Annot>> endobj 610 0 obj <>/Border[0 0 0]/H/N/Rect[274.961 519.291 340.4 509.995]/Subtype/Link/Type/Annot>> endobj 611 0 obj <>/Border[0 0 0]/H/N/Rect[366.447 489.291 486.878 479.995]/Subtype/Link/Type/Annot>> endobj 612 0 obj <>/Border[0 0 0]/H/N/Rect[302.157 449.291 357.268 439.995]/Subtype/Link/Type/Annot>> endobj 613 0 obj <>/Border[0 0 0]/H/N/Rect[375.791 419.291 472.406 409.995]/Subtype/Link/Type/Annot>> endobj 614 0 obj <>/Border[0 0 0]/H/N/Rect[429.097 389.291 493.161 379.835]/Subtype/Link/Type/Annot>> endobj 615 0 obj <>/Border[0 0 0]/H/N/Rect[407.051 349.291 492.234 339.835]/Subtype/Link/Type/Annot>> endobj 616 0 obj <>/Border[0 0 0]/H/N/Rect[387.907 319.291 470.266 309.835]/Subtype/Link/Type/Annot>> endobj 617 0 obj <>/Border[0 0 0]/H/N/Rect[418.8 279.291 492.256 269.835]/Subtype/Link/Type/Annot>> endobj 618 0 obj <>/Border[0 0 0]/H/N/Rect[404.456 259.291 459.568 249.835]/Subtype/Link/Type/Annot>> endobj 619 0 obj <>/Border[0 0 0]/H/N/Rect[289.739 229.291 391.818 219.995]/Subtype/Link/Type/Annot>> endobj 620 0 obj <>/Border[0 0 0]/H/N/Rect[289.739 199.291 372.394 189.995]/Subtype/Link/Type/Annot>> endobj 621 0 obj <>/Border[0 0 0]/H/N/Rect[380.065 159.291 471.544 149.835]/Subtype/Link/Type/Annot>> endobj 622 0 obj <>/Border[0 0 0]/H/N/Rect[289.739 119.291 391.234 109.995]/Subtype/Link/Type/Annot>> endobj 623 0 obj <>/Border[0 0 0]/H/N/Rect[440.223 99.2913 496.063 89.8352]/Subtype/Link/Type/Annot>> endobj 624 0 obj <>/Border[0 0 0]/H/N/Rect[274.961 89.2913 312.144 79.9952]/Subtype/Link/Type/Annot>> endobj 665 0 obj <> endobj 664 0 obj <> endobj 663 0 obj <> endobj 662 0 obj <> endobj 661 0 obj <> endobj 660 0 obj <> endobj 659 0 obj <> endobj 658 0 obj <> endobj 657 0 obj <> endobj 656 0 obj <> endobj 655 0 obj <> endobj 654 0 obj <> endobj 653 0 obj <> endobj 652 0 obj <> endobj 651 0 obj <> endobj 650 0 obj <> endobj 649 0 obj <> endobj 648 0 obj <> endobj 647 0 obj <> endobj 646 0 obj <> endobj 645 0 obj <> endobj 644 0 obj <> endobj 643 0 obj <> endobj 642 0 obj <> endobj 641 0 obj <> endobj 640 0 obj <> endobj 639 0 obj <> endobj 638 0 obj <> endobj 637 0 obj <> endobj 636 0 obj <> endobj 635 0 obj <> endobj 634 0 obj <> endobj 633 0 obj <> endobj 632 0 obj <> endobj 631 0 obj <> endobj 630 0 obj <> endobj 629 0 obj <> endobj 628 0 obj <> endobj 627 0 obj <> endobj 626 0 obj <> endobj 625 0 obj <> endobj 493 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.137 Tw 10 0 0 10 70.8661 724.8299 Tm (\007\024\022\026\026\021\036\035\034\f\021\r\026 \024)Tj /Span<>> BDC ( )Tj EMC (\r\035\017\016\027\017\017 \205\202 \027\026)Tj /Span<>> BDC ( )Tj EMC (\007\024\030\024\r\034\036, \022\024\021\024\030\t\036 )Tj 0.298 Tw 0 -1.218 TD (\n\024\020\031\021 \002\t\021\034 \023\024\007\021\r\036\030\032\007\036\ \027\t \022\024\035\017\004\036\f\021\r\036\027\027\t\n\017 \017\n\036)Tj 0 Tw (-)Tj 0.169 Tw T* (\027\036\027\017\016\n\017 \031\030\024\r\027\036\005 \002\017\024\020\031\ \n\024\030\026\035\034\027\t\b \023\024\022\026\026\021\036\035\036\005\ , \004\021\024 )Tj -0.009 Tw T* (\023\030\036\007\f\021\026\r\035\016\036\021 \f\024\002\024\005 \007\024\ \023\024\035\027\017\021\036\035\034\027\031\033 \023\024\007\007\036\030\ \032\022\031 \022\024\027)Tj 0 Tw (-)Tj 0.002 Tw T* (\006\036\023\006\017\017 \030\024\035\017 \205\202 \r)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\r\017\004\027\024\005 \017)Tj /Span<>> BDC ( )Tj EMC (\r\021\024\030\017\004\027\024\005 \023\030\024\235\017\035\026\022)Tj 0 Tw (-)Tj T* (\021\017\022\036 \216\203\222\003 [72].)Tj 0.024 Tw 0 -1.218 TD (\217\024\035\034 \205\202 \r)Tj /Span<>> BDC ( )Tj EMC (\022\026\004\036\f\021\r\036 \021\036\030\026\023\036\r\021\017\004\036\f\ \022\024\020\024 \r\026\030\017\026\027\021\026 \035\036\004\036)Tj 0 Tw (-)Tj -0.016 Tw 0 -1.218 TD (\027\017\016 \024\004\036\r\017\007\027\026 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (26 \030\026\035\017\004\027\t\b \b\030\024\027\017\004\036\f\022\017\b \ \026\002\024\035\036)Tj 0 Tw (-)Tj -0.035 Tw T* (\r\026\027\017\016\b, \021\026\022\017\b \022\026\022: \023\f\017\b\017\004\ \036\f\022\017\036 \026\002\024\035\036\r\026\027\017\016 \(\007\036\023\ \030\036\f)Tj 0 Tw (-)Tj 0.078 Tw T* (\f\017\016, \021\030\036\r\024\020\026, \f\021\030\036\f\f, \001\017\024\ \235\030\036\027\017\016\); \027\036\r\030\024\035\024\020\017\004\036\f\ \022\017\036 )Tj 0.051 Tw T* [(\026\002\024\035\036\r\026\027\017\016 \(\007\036\n\036\027\006\017\016\ , )0.5(\002\024\035\036\027\034 \215\026\030\022\017\027\f\024\027\026, \030\026\ \f\f\036)]TJ 0 Tw (-)Tj 0.057 Tw T* [(\016\027\027\t\005 \f\022\035\036\030\024\); \n\036\021\026\002\024\035\ \017\004\036\f\022\017\036 )0.5(\026\002\024\035\036\r\026\027\017\016 )0.5(\(\024\032\017)]TJ 0 Tw (-)Tj 0.405 Tw 0 -1.218 TD [(\030\036\027\017\036, )0.5(\020\017\023\036\030\035\017\023\017\007\036\n\017\016, )0.6(\n\036\021\026\002\024\035\017\004\036\f\022\017\005 )0.6(\f\017\027\007\030\024\n, )]TJ -0.048 Tw 0 -1.218 TD (\f\017\027\007\030\024\n \023\024\035\017\022\017\f\021\024\027\t\b \016\ \017\004\027\017\022\024\r, \221\212 2, \f\026\b\026\030\027\t\005 \007\017\ )Tj 0 Tw (-)Tj 0.043 Tw 0 -1.218 TD (\026\002\036\021 1 \021\017\023\026\); \207\221\025 \(\020\017\023\036\030\ \021\024\027\017\004\036\f\022\026\016 \002\024\035\036\027\034, \017\001\ \036\n\017)Tj 0 Tw (-)Tj 0.171 Tw T* (\004\036\f\022\026\016 \002\024\035\036\027\034 \f\036\030\007\006\026,\ \f\036\030\007\036\004\027\026\016 \027\036\007\024\f\021\026\021\024\004\ \027\024\f\021\034, )Tj -0.019 Tw T* (\017\027\f\031\035\034\021 \020\024\035\024\r\027\024\020\024 \n\024\020\ \026, \023\036\030\036\n\036\032\026\033\013\026\016\f\016 \b\030\024\n\024\ \021\026\); )Tj 0.199 Tw T* [(\035\036\020\024\004\027\t\036 )0.6(\026\002\024\035\036\r\026\027\017\016 )0.5(\(\b\030\024\027\017\004\036\f\022\026\016 )0.5(\024\002\f\021\030\031\022\021\017\r\027\026\016 )]TJ 0.023 Tw T* (\002\024\035\036\027\034 \035\036\020\022\017\b, \002\030\024\027\b\017\ \026\035\034\027\026\016 \026\f\021\n\026, \n\031\022\024\r\017\f\006\017\ \007\024\); )Tj 0.022 Tw T* [(\026\002\024\035\036\r\026\027\017\016 )0.6(\024\023\024\030\027\024-\007\r\017\020\026\021\036\035\034\027\024\020\024\ )0.6(\026\023\023\026\030\026\021\026 )0.5(\(\024\f\021\036\024)]TJ 0 Tw (-)Tj 0.072 Tw T* (\026\030\021\030\024, \024\f\021\036\024\023\024\030\024, \002\024\035\ \017 \r)Tj /Span<>> BDC ( )Tj EMC (\f\023\017\027\036, \030\036\r\n\026\021\024\017\007\027\t\005 \026\030)Tj 0 Tw (-)Tj T* (\021\030\017\021\); \017)Tj /Span<>> BDC ( )Tj EMC (\030\026\022 [22].)Tj 0.305 Tw T* (\025\026\022 \002\t\035\024 \023\030\024\007\036\n\024\027\f\021\030\017\ \030\024\r\026\027\024, \017\f\023\024\035\034\024\r\026\027\017\036 \205\ \211 )Tj 0.098 Tw T* (\031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\200\003\025 \n\024\032\027\024 \f\004\017\021\026\021\034 \002\036\024\ \023\026\f\027\t\n \017)Tj /Span<>> BDC ( )Tj EMC (\023\024)Tj 0 Tw (-)Tj 0.175 Tw T* [(\035\036\027\t\n )0.5(\007\035\016 )0.6(\024\002\013\036\020\024 )0.5(\f\024\f\021\024\016\027\017\016 )0.5(\007\024\030\024\r\034\016 )0.5(\023\026\006\017\036\027\021\024\r, )]TJ -0.002 Tw T* (\026)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\032\036 \007\035\016 \022\024\027\022\030\036\021\027\t\b \235\ \017\017\004\036\f\022\017\b \017)Tj /Span<>> BDC ( )Tj EMC (\023\f\017\b\024\f\024\006\017\026\035\034)Tj 0 Tw (-)Tj 0.02 Tw T* [(\027\t\b )0.5(\f\017\n\023\021\024\n\024\r )0.6(\200\003\025. )0.5(\205\211 )0.5(\023\024\035\024\032\017\021\036\035\034\027\024 )0.6(\r\035\017\016\033\021 )0.6(\027\026)]TJ /Span<>> BDC ( )Tj EMC 20.669 0 Td (\017\n)Tj 0 Tw (-)Tj 0.13 Tw -20.669 -1.218 Td (\n\031\027\027\t\005 \024\021\r\036\021. \211)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \027\026\002\035\033\007\026\036\021\f\ \016 \031\035\031\004\001\036\027\017\036 )Tj 0.043 Tw T* (\235\017\017\004\036\f\022\024\005 \235\024\030\n\t, \n\017\027\036\030\ \026\035\034\027\024\005 \023\035\024\021\027\024\f\021\017 \022\024\f\021\ \027\024\005 )Tj -0.035 Tw T* (\021\022\026\027\017, \022\026\004\036\f\021\r\026 \032\017\027\017, \f\ \027\017\032\036\027\017\036 \f\021\030\036\f\f\026 \017)Tj /Span<>> BDC ( )Tj EMC (\002\036\f\023\024\022\024\005)Tj 0 Tw (-)Tj T* (\f\021\r\026, \r\t\r\026\027\027\t\b \200\003\025 [16,53].)Tj -0.002 Tw T* (\200\t\016\f\027\036\027\017\036 \024\f\021\030\t\b \017)Tj /Span<>> BDC ( )Tj EMC (\b\030\024\027\017\004\036\f\022\017\b \023\030\024- \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\021\017\r\024\r\024\f)Tj 0 Tw (-)Tj 0.002 Tw T* (\023\026\035\017\021\036\035\034\027\t\b \030\036\026\022\006\017\005 \023\ \030\017)Tj /Span<>> BDC ( )Tj EMC (\205\211 \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \200\003\025, \n\024\032\036\021 )Tj 0.062 Tw T* (\007\026\021\034 \002\024\035\034\001\036\036 \024\002\024\f\027\024\r\026\ \027\017\036 \007\035\016 \023\030\017\n\036\027\036\027\017\016 \205\211\ \r)Tj /Span<>> BDC ( )Tj EMC (\022\026)Tj 0 Tw (-)Tj 0.012 Tw T* (\004\036\f\021\r\036 \f\021\030\026\021\036\020\017\017 \035\036\004\036\ \027\017\016. \230\036\n \027\036 \n\036\027\036\036, \017\f\023\024\035\ \034\024\r\026)Tj 0 Tw (-)Tj -0.035 Tw T* (\027\017\036 \205\211 \r)Tj /Span<>> BDC ( )Tj EMC (\022\026\004\036\f\021\r\036 \007\024\023\024\035\027\017\021\036\035\034\ \027\024\005 \f\021\030\026\021\036\020\017\017 \035\036\004\036\027\017\ \016 )Tj -0.034 Tw T* (\023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\200\003\025 \r)Tj /Span<>> BDC ( )Tj EMC (\f\021\026\007\017\017 \030\036\n\017\f\f\017\017 \024\002\024\f\027\024\ \r\026\027\024 [9,16,)Tj 0 Tw ( )Tj 0.264 Tw T* (28,34,36,38,50,59,60,61,63,64]. \202\007\255\033\r\026\027\021\027\026\016\ \021\036\030\026\023\017\016 )Tj 0.065 Tw T* (\030\026\f\f\n\026\021\030\017\r\026\036\021\f\016 \022\026\022 \f\030\036\ \007\f\021\r\024 \007\035\016 \024\002\035\036\020\004\036\027\017\016 \f\ \017\n\023)Tj 0 Tw (-)Tj -0.005 Tw T* (\021\024\n\024\r \200\003\025 [22,73]. \205\202 \023\030\036\007\f\021\026\ \r\035\016\036\021 \f\024\002\024\005 \036\f\021\036\f\021\r\036\027)Tj 0 Tw (-)Tj 0.589 Tw T* (\027\031\033, \f\017\035\034\027\031\033 \023\030\024\021\017\r\024\r\024\ \f\023\026\035\017\021\036\035\034\027\031\033 \f\021\030\026\021\036\020\ \017\033 )Tj 0.043 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\027\036\027\026\004\017\021\036\035\034\027\t\n\017 \023\024\002\024\004\ \027\t\n\017 \220\235\235\036\022\021\026\n\017 \017)Tj /Span<>> BDC ( )Tj EMC (\007\024\035\032\027\026 )Tj 0.189 Tw T* (\002\t\021\034 \017\027\021\036\020\030\017\030\024\r\026\027\026 \r)Tj /Span<>> BDC ( )Tj EMC (\035\036\004\036\027\017\036 \023\026\006\017\036\027\021\024\r \r)Tj /Span<>> BDC ( )Tj EMC (\f\021\026\007\017\017 )Tj 0 Tw T* (\030\036\n\017\f\f\017\017 [70].)Tj 0.172 Tw T* [(\200\030\024\f\035\t\036 )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC [(\200\003\025 \017\013\031\021 )0.5(\f\021\030\026\021\036\020\017\017 \f\026\n\024\022\024\027\021\030\024\035\ \016, )0.5(\004\021\024)]TJ 0 Tw (-)Tj 0.27 Tw T* (\002\t \f\023\030\026\r\017\021\034\f\016 \f\024 \f\r\024\017\n\017 \f\017\ \n\023\021\024\n\026\n\017 \017)Tj /Span<>> BDC ( )Tj EMC (\031\035\031\004\001\017\021\034 )Tj 0.299 Tw T* [(\022\026\004\036\f\021\r\024 \032\017\027\017. )0.5(\205\202 \016\r\035\016\036\021\f\016 )0.5(\024\007\027\024\005 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC (\f\021\030\026\021\036\020\017\005 )Tj 0.399 Tw T* (\f\026\n\024\022\024\027\021\030\024\035\016, \022\024\021\024\030\031\033\ \n\024\020\031\021 \017\f\023\024\035\034\024\r\026\021\034 \023\026\006\ \017)Tj 0 Tw (-)Tj 0.155 Tw T* (\036\027\021\t \f)Tj /Span<>> BDC ( )Tj EMC (\200\003\025. \202\007\255\033\r\026\027\021\027\026\016 \027\036\n\036\007\ \017\022\026\n\036\027\021\024\027\026\016 \021\036\030\026)Tj 0 Tw (-)Tj 0.302 Tw T* (\023\017\016 \200\003\025 \r\022\035\033\004\026\036\021 \030\036\022\024\ \n\036\027\007\026\006\017\017 \023\024)Tj /Span<>> BDC ( )Tj EMC (\f\026\n\024\023\024\n\024\013\017. )Tj 0.141 Tw T* (\203\036\024\002\b\024\007\017\n\024 \017\027\235\024\030\n\017\030\024\r\ \026\021\034 \023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\200\003\025 \024)Tj /Span<>> BDC ( )Tj EMC (\n\036)Tj 0 Tw (-)Tj 0.254 Tw T* (\021\024\007\026\b \f\026\n\024\023\024\n\024\013\017 \017)Tj /Span<>> BDC ( )Tj EMC (\007\026\r\026\021\034 \r\030\026\004\026\n \030\036\022\024\n\036\027\007\ \026\006\017\017 )Tj -0.025 Tw T* (\024)Tj /Span<>> BDC ( )Tj EMC (\021\024\n, \022\026\022 \027\026\023\030\026\r\035\016\021\034 \f\r\024\ \017\b \023\026\006\017\036\027\021\024\r \023\024\f\035\036 \035\036\004\ \036\027\017\016 )Tj 0.198 Tw T* (\024\002\024\f\021\030\036\027\017\016 \200\003\025. \217\036\020\031\035\ \016\030\027\026\016 \205\202 \027\017\022\024\005 \031\n\036\030\036\027\ \027\024\005 )Tj 0.146 Tw 23.244 64.543 Td (\017\027\021\036\027\f\017\r\027\024\f\021\017, \r\022\035\033\004\026\016\ \f\036\030\007\036\004\027\024-\f\024\f\031\007\017\f\021\t\036 \017)Tj /Span<>> BDC ( )Tj EMC (\f\017)Tj 0 Tw (-)Tj -0.082 Tw T* (\035\024\r\t\036 \031\023\030\026\032\027\036\027\017\016, \031\035\031\004\ \001\026\036\021 \022\026\004\036\f\021\r\024 \032\017\027\017 \002\024\ \035\034\027\t\b )Tj 0.091 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\n\024\032\036\021 \031\n\036\027\034\001\026\021\034 \r\024\f\023\026\035\ \036\027\017\036. \202\007\255\033\r\026\027\021\027\t\036 \n\036\021\024\ )Tj 0 Tw (-)Tj 0.16 Tw T* (\007\t \035\036\004\036\027\017\016 \016\r\035\016\033\021\f\016 \n\027\024\ \020\024\024\002\036\013\026\033\013\017\n\017 \017)Tj /Span<>> BDC ( )Tj EMC (\007\024\035\032\027\t )Tj 0.109 Tw T* [(\017\f\023\024\035\034\024\r\026\021\034\f\016 )0.6(\007\035\016 )0.5(\002\024\035\036\036 )0.5(\006\036\035\024\f\021\027\024\020\024 )0.6(\023\024\007\b\024\007\026 )0.5([74]. )]TJ 0.222 Tw T* [(\206\026\f\021\030\024\220\027\021\036\030\024\035\024\020\017 )0.5(\007\035\016 \031\004\026\f\021\017\016 \r)]TJ /Span<>> BDC ( )Tj EMC (\017\027\235\024\030\n\017\030\024\r\026\027\027\t\b )Tj 0.011 Tw 0 -1.218 TD (\017)Tj /Span<>> BDC ( )Tj EMC (\f\024\007\036\030\032\026\021\036\035\034\027\t\b \007\017\f\022\031\f\f\ \017\016\b \f\024 \f\r\024\017\n\017 \023\026\006\017\036\027\021\026\n\017\ )Tj 0.075 Tw 0 -1.218 TD (\024)Tj /Span<>> BDC ( )Tj EMC (\030\024\035\017 \205\202 \r)Tj /Span<>> BDC ( )Tj EMC (\200\003\025 \007\024\035\032\027\t \002\t\021\034 \031\002\036\007\017\021\ \036\035\034\027\t, \017\f\023\024\035\034)Tj 0 Tw (-)Tj 0.031 Tw T* [(\031\016 \023\024\035\031\004\036\027\027\t\036 \007\026\027\027\t\036 \ )0.5([56]. \210\007\027\026\022\024 )0.5(\031\004\026\f\021\027\017\022\017 )0.5(\n\027\024)]TJ 0 Tw (-)Tj 0.047 Tw T* (\020\017\b \017\f\f\035\036\007\024\r\026\027\017\005 \f\024\024\002\013\ \026\033\021 \024)Tj /Span<>> BDC ( )Tj EMC (\004\026\f\021\024\n \024\021\f\031\021\f\021\r\017\017 \024\002)Tj 0 Tw (-)Tj 0.011 Tw T* (\f\031\032\007\036\027\017\016 \023\024\035\034\t \205\211 \007\035\016\ \007\024\030\024\r\034\016 \f)Tj /Span<>> BDC ( )Tj EMC (\035\036\004\026\013\017\n \r\030\026\004\024\n )Tj -0.011 Tw T* ([55]. \230\026\022, \r)Tj /Span<>> BDC ( )Tj EMC (\022\024\027\022\030\036\021\027\024\n \017\f\f\035\036\007\024\r\026\027\ \017\017 46,1% \031\004\026\f\021\027\017)Tj 0 Tw (-)Tj -0.011 Tw 0 -1.218 TD (\022\024\r \()Tj /T1_1 1 Tf 0 Tw (n)Tj /T1_0 1 Tf -0.011 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (158\) \023\024\007\021\r\036\030\007\017\035\017 \024\021\f\031\021\f\021\ \r\017\036 \024\002\f\031\032\007\036\027\017\016 \205\211 )Tj -0.018 Tw 0 -1.218 TD (\f)Tj /Span<>> BDC ( )Tj EMC (\017\b \n\036\007\017\006\017\027\f\022\017\n\017 \030\026\002\024\021\027\ \017\022\026\n\017 [58]. \203\024 \030\036\022\024\n\036\027\007\026)Tj 0 Tw (-)Tj 0.027 Tw 0 -1.218 TD (\006\017\017 \r\030\026\004\026 \023\024)Tj /Span<>> BDC ( )Tj EMC (\205\202 \r)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\017\024\007 \030\036\n\017\f\f\017\017 \017)Tj /Span<>> BDC ( )Tj EMC (\030\036\022\024\n\036\027\007\026\006\017\017 )Tj 0.226 Tw T* (\023\024)Tj /Span<>> BDC ( )Tj EMC (\f\026\n\024\023\024\n\024\013\017 \007\024\035\032\027\t \017\f\023\024\ \035\034\024\r\026\021\034\f\016 \007\035\016 \002\024\035\036\036 )Tj 0.157 Tw T* (\006\036\035\024\f\021\027\024\020\024 \023\024\007\b\024\007\026 \023\024\ \f\035\036 \035\036\004\036\027\017\016 \024\002\024\f\021\030\036\027\017\ \016 \200\003\025 )Tj -0.018 Tw T* [(\007\035\016 \023\030\024\235\017\035\026\022\021\017\022\017 \200\003\025\ , )0.5(\220\021\024\020\024 \f\035\024\032\027\024\020\024 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC (\007\024\030\024\020\024\f\021\024\016)Tj 0 Tw (-)Tj 0.045 Tw T* (\013\036\020\024 \026\002\024\035\036\r\026\027\017\016 [75]. \215\026\006\ \017\036\027\021\t \007\024\035\032\027\t \002\t\021\034 \023\030\024)Tj 0 Tw (-)Tj 0.276 Tw T* (\017\027\235\024\030\n\017\030\024\r\026\027\t \024\002 \026\007\255\033\ \r\026\027\021\027\t\b \n\036\021\024\007\026\b \035\036\004\036\027\017\ \016 )Tj 0.157 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\023\030\036\007\024\021\r\030\026\013\036\027\017\016 \024\f\035\024\032\ \027\036\027\017\005, \f\r\016\026\027\027\t\b \f)Tj /Span<>> BDC ( )Tj EMC (\017\b \f\024)Tj 0 Tw (-)Tj 0.031 Tw T* (\f\021\024\016\027\017\036\n, \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\n \017\027\007\017\r\017\007\031\031\n\031 \024\021\r\024\007\ \017\021\f\016 \026\022\021\017\r\027\026\016 )Tj 0 Tw T* (\030\024\035\034 \r)Tj /Span<>> BDC ( )Tj EMC (\017\b \r\t\023\024\035\027\036\027\017\017.)Tj /T1_2 1 Tf 0.023 Tw 0 -2.436 TD (\223\030\032\255\020\034\036 \032\026\020\017\022\017\026)Tj /T1_0 1 Tf 0.449 Tw 0 -1.218 TD [(\025)-4.1(\024)-4.3(\027)1.7(\006)-6(\036)-6.8(\023)2.2(\006)-6(\017)-5.4(\016 \017)]TJ /Span<>> BDC ( )Tj EMC [(\007)-6(\017)2.7()-9.9(\026\005)1.7(\027 \024)-11.8(\002)7.5()-5.1(\024)0.8(\030)-11.4(\026)-28.4(, \f)-14.2(\002)-9.9(\024)0.7(\030 \017)]TJ /Span<>> BDC ( )Tj EMC [(\024)-11.8(\002)3(\030)-11.4(\026)-6.3(\002)-9.9(\024)-10.9(\021)-17.7(\022)-19.1(\026 )]TJ 0.34 Tw T* [(\035)2.2(\017)-13.3(\021)-9.9(\036)-1.7(\030)-11.4(\026)-11.8(\021)-50.9(\031)-22.5(\030)-7.6(\t)-18.9(, \027)-0.6(\026)-1.9(\023)2.2(\017)-2.4(\f)-12.8(\026\027)1.7(\017)-8.7(\036 \021)-9.9(\036)-5.4(\022)-1.7(\f)-36(\021)-21.4(\026 \017)]TJ /Span<>> BDC ( )Tj EMC [(\030)-16.2(\036)-19(\007)-20.1(\026\022)-32.6(\021)-17.7(\017)1.4(\030)-11.8(\024)-4.3(\r)-8.9(\026\027)1.7(\017)-8.7(\036)6.5(:)]TJ /T1_1 1 Tf 0 Tw ( )Tj -0.005 Tc 0.005 Tw T* [(\222)10.6(\n)-5.8(\t)-4.9(\024)4.6(\007\013)4.8(\031)1.6(\027)0.5(\025)14.3(\006)]TJ /Span<>> BDC 5.064 0 Td ( )Tj EMC [(\207)-7.1(.)23.5(\216)19.3(.)2.8(,)-5( \213\026\013)-22.7(\205)18.8(\023)4.6(\025)2.2(\021)]TJ /Span<>> BDC 5.512 0 Td ( )Tj EMC [(\215)23.8(.)24.3(\210)117(.)]TJ /T1_2 1 Tf 0 Tc 0.023 Tw -10.576 -2.436 Td (AUTHORS CONTRIBUTION)Tj /T1_0 1 Tf 0.061 Tw T* [(C)-6.5(o)0.8(nce)-0.7(p)-12.3(t a)2.4(n)-4.6(d d)-5.5(e)-13.3(s)-16.6(i)3.2(g)1.2(n o)-2.2(f t)-16.7(h)-5.3(e r)-9.4(e)-6(v)-43.2(i)-1.1(e)-2.7(w)6.1(, c)3.7(o)-5.8(l)-19(l)-14.3(e)-9.4(c)-32.5(t)-37.4(i)3.2(o)0.8(n a)2.5(n)-4.7(d p)-3.8(r)-6(o)]TJ 0 Tw 21.758 0 Td (-)Tj 0.09 Tw -21.758 -1.218 Td [(ce)-13.3(s)-12.8(s)-16.6(i)7.1(n)-1.9(g o)-2.2(f l)-6.9(i)-6(t)-15.2(e)-2.1(r)-21.5(a)-8.4(t)-12.8(u)2.4(r)-9.4(e)-19.8(, W)3.1(r)-47.9(i)-6(t)-37.4(i)7.1(n)-1.9(g o)-2.2(f t)-16.7(h)-5.3(e t)-15.2(e)-23.8(x)-36(t a)2.4(n)-4.6(d e)-11.3(d)-6(i)-6(t)-37.4(i)7.1(n)-1.9(g)9(:)]TJ /T1_1 1 Tf 0 Tw ( )Tj T* [(S)5.6(e)-1.7(r)2.3(g)-2.5(e)-2.5(y)]TJ /Span<>> BDC ( )Tj EMC [(V)53.2(.)]TJ /Span<>> BDC ( )Tj EMC [(K)13.3(o)3.3(s)-10.7(t)-30(y)3.8(u)4.6(k)12.9(e)-3.9(v)-28.6(i)2.6(c)1.8(h)-6(, I)10(g)-2.5(o)1.3(r)]TJ /Span<>> BDC ( )Tj EMC [(G)-1.4(.)]TJ /Span<>> BDC ( )Tj EMC [(B)6.8(a)1.7(k)12.5(u)2.8(l)4.3(i)8.4(n)]TJ /T1_2 1 Tf 0.023 Tw 0 -2.436 TD (\255\026\036\031\036\025\034\224 \017\225 \032\026\020\017\022\032\221 \(\ ORCID\))Tj /T1_0 1 Tf 0.387 Tw 0 -1.218 TD (\025\024\f\021\033\022\036\r\017\004 \221\036\030\020\036\005 \200\035\026\ \007\017\n\017\030\024\r\017\004)Tj /Span<>> BDC ( )Tj EMC (\227 \007\024\022\021\024\030 \n\036)Tj 0 Tw (-)Tj 0.383 Tw T* (\007\017\006\017\027\f\022\017\b \027\026\031\022, \026\r\036\007\031\033\ \013\017\005 \022\026\235\036\007\030\024\005 \n\036\007\017\006\017\027\ )Tj 0 Tw (-)Tj 0.479 Tw T* (\f\022\024\005 \002\017\024\035\024\020\017\017 \205\206\207\210\211 \200\ \210 \253\221\036\r\036\030\024-\003\026\023\026\007\027\t\005 \020\024)Tj 0 Tw (-)Tj 0.65 Tw T* (\f\031\007\026\030\f\021\r\036\027\027\t\005 \n\036\007\017\006\017\027\f\ \022\017\005 \031\027\017\r\036\030\f\017\021\036\021 \017\n\036\027\017\ )Tj 0 Tw T* (\222.\222.)Tj /Span<>> BDC ( )Tj EMC (\204\036\004\027\017\022\024\r\026\273; ORCID 0000-0002-4548-063X)Tj 0.259 Tw T* (\207\026\022\031\035\017\027 \222\020\024\030\034 \206\036\027\027\026\007\ \034\036\r\017\004)Tj /Span<>> BDC ( )Tj EMC (\227 \023\030\024\235\036\f\f\024\030, \007\024\022\021\024\030 )Tj -0.048 Tw T* (\n\036\007\017\006\017\027\f\022\017\b \027\026\031\022, \007\036\022\026\ \027 \035\036\004\036\002\027\024\020\024 \235\026\022\031\035\034\021\036\ \021\026, \026\r\036)Tj 0 Tw (-)Tj 0.126 Tw T* (\007\031\033\013\017\005 \022\026\235\036\007\030\024\005 \023\030\024\023\ \036\007\036\r\021\017\022\017 \r\027\031\021\030\036\027\027\017\b \002\ \024\035\036)Tj 0 Tw (-)Tj 0.06 Tw T* (\027\036\005, \020\026\f\021\030\024\220\027\021\036\030\024\035\024\020\ \017\017 \017)Tj /Span<>> BDC ( )Tj EMC (\007\017\036\021\024\035\024\020\017\017 \017\n. \221.\204.)Tj /Span<>> BDC ( )Tj EMC (\217\t\f\f\026 )Tj 0.035 Tw T* (\205\206\207\210\211 \200\210 \253\221\036\r\036\030\024-\003\026\023\026\ \007\027\t\005 \020\024\f\031\007\026\030\f\021\r\036\027\027\t\005 \n\036\ \007\017)Tj 0 Tw (-)Tj 0.029 Tw T* (\006\017\027\f\022\017\005 \031\027\017\r\036\030\f\017\021\036\021 \017\ \n\036\027\017 \222.\222.)Tj /Span<>> BDC ( )Tj EMC (\204\036\004\027\017\022\024\r\026\273; ORCID )Tj 0 Tw T* (0000-0002-6151-2021)Tj /T1_2 1 Tf 0.023 Tw 0 -2.436 TD (INFORMATION ABOUT THE AUTHORS \(ORCID\))Tj /T1_0 1 Tf 0 Tw 0 -1.218 TD [(Ser)-32(ge)-11(y V. K)25.1(ost)-10(yuk)10(ev)-15.9(ich)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0002-4548-063X)Tj T* [(Igor G. Bakul)-30.9(in)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0002-6151-2021)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\214)10(\211\036\033 \035\030\032\t\033)30(\b)42(\032)-21(\240\033\233)]TJ 57.136 0 Td (REVIEW)Tj -57.136 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 23, \023\0221)69(, 202)69(4)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 23, \023\0221)69(, 202)69(4)]TJ /T1_4 1 Tf 25 0 0 25 20.7403 56.0378 Tm (158)Tj ET endstream endobj 492 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\210\220\222\220\017\016\006\n\220\016 \215\221\002\013\217\001\016\001\220\ \205 \n\013\n \232\225\225\016\n)-9.9(\026\220\r\001\013\205 )]TJ 0 -1 TD [(\013\201\230\212\r\013\001\026\001\013\205 \026)11(\016\002\013\221\220\205 \221\002\220\022\002\016\024\220\006\006\220\220\ \r\025\006\221\013\007\220\026)11(\016\007\216\001\020\207 )]TJ T* [(\222\013\f\025\007\016\r\013\001\220\203 \n\220\016\017\001\220\n\013 \(\ \025\f\222\025\002 \007\220\026)11(\016\002\013\026)-19.9(\215\002\020\))]TJ 43.88 2 Td [(Ph)31(y)10(sical e)21(x)10(er)31(cises as an ef)-30.9(fectiv)12(e adju)10(v)10(ant )]TJ 2.526 -1 Td [(th)11(er)21(apy of IBD in r)31.1(emission \(r)31(e)11(vie)11(w\))]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0.023 Tw 10 0 0 10 42.5197 724.8299 Tm (\022\r\202\t\214\013 \203\032 \240\f\235 \212\004\204\t\r\b\003\002 \217\ )Tj /Span<>> BDC ( )Tj EMC (\026\033\021)Tj /T1_2 1 Tf 0.336 Tw 0 -1.218 TD (\216\024\030\024\001\024 \017\r\036\f\021\027\024, \004\021\024 \023\024\ \f\035\036 \017\027\021\036\027\f\017\r\027\024\005 \205\203 \027\026)Tj 0 Tw (-)Tj 0.387 Tw T* [(\002\035\033\007\026\036\021\f\016 )0.6(\r\030\036\n\036\027\027\024\036 )0.5(\023\024\r\t\001\036\027\017\036 )0.5(\006\017\030\022\031\035\017\030\031\033\013\017\b )]TJ 0.385 Tw T* (\031\030\024\r\027\036\005 \023\030\024\021\017\r\024\r\024\f\023\026\035\ \017\021\036\035\034\027\t\b \006\017\021\024\022\017\027\024\r, \021\024\ \020\007\026 )Tj 0.038 Tw T* (\022\026\022 \b\030\024\027\017\004\036\f\022\026\016 \205\203 \f\027\017\ \032\026\036\021 \002\026\026\035\034\027\t\036 \031\030\024\r\027\017 \ \023\030\024)Tj 0 Tw (-)Tj -0.018 Tw T* (\r\024\f\023\026\035\017\021\036\035\034\027\t\b \006\017\021\024\022\017\ \027\024\r [69]. \221\007\036\030\032\026\027\027\t\005 \023\024\007\b\024\ \007 )Tj 0.053 Tw 0 -1.218 TD (\022)Tj /Span<>> BDC ( )Tj EMC (\205\211 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\200\003\025 \f\r\016\026\027 \f)Tj /Span<>> BDC ( )Tj EMC (\021\036\n, \004\021\024 \205\202 \024\021 \027\017\022\024\005 \007\024\ )Tj /Span<>> BDC ( )Tj EMC (\031\n\036)Tj 0 Tw (-)Tj 0.158 Tw 0 -1.218 TD [(\030\036\027\027\024\005 )0.5(\022\026\032\036\021\f\016 )0.5(\002\036\024\023\026\f\027\024\005 )0.6(\007\035\016 )0.5(\023\026\006\017\036\027\021\024\r )0.6(\f)]TJ /Span<>> BDC ( )Tj EMC 19.721 0 Td [(\200\003\025 )0.5(c )]TJ 0.149 Tw -19.721 -1.218 Td (\035\036\020\022\017\n \017)Tj /Span<>> BDC ( )Tj EMC (\031\n\036\030\036\027\027\t\n \021\036\004\036\027\017\036\n, \027\024 \ \r)Tj /Span<>> BDC ( )Tj EMC (\007\r\031\b \017)Tj /Span<>> BDC ( )Tj EMC (13 \017\f)Tj 0 Tw (-)Tj 0.399 Tw T* (\f\035\036\007\024\r\026\027\017\005 \f\024\024\002\013\026\035\024\f\034\ \024)Tj /Span<>> BDC ( )Tj EMC (\027\036\002\024\035\034\001\024\n \022\024\035\017\004\036\f\021\r\036 \ )Tj 0.212 Tw T* (\203\247 \f\030\026\031 \023\024\f\035\036 \205\211. \212\026\027\027\024\ \036 \r\035\017\016\027\017\036 \r\n\036\001\026\021\036\035\034\f\021\r\ )Tj 0.051 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC (\023\026\030\026\n\036\021\030\t \007\024\030\024\r\034\016 \n\024\020\035\ \024 \002\t\021\034 \r\t\r\026\027\024 \027\036\024\007\027\024)Tj 0 Tw (-)Tj 0.119 Tw 0 -1.218 TD (\030\024\007\027\t\n\017 \n\036\021\024\007\026\n\017 \021\030\036\027\017\ \030\024\r\024\022 \017)Tj /Span<>> BDC ( )Tj EMC (\r\t\002\030\026\027\027\024\005 \017\027\021\036\027)Tj 0 Tw (-)Tj 0 -1.218 TD (\f\017\r\027\024\f\021\034\033 [35,53].)Tj 0.048 Tw 0 -1.218 TD (\230\017\023 \017)Tj /Span<>> BDC ( )Tj EMC (\024\002\255\036\n \031\023\030\026\032\027\036\027\017\005 \007\035\016\ \023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\200\003\025 \007\024\035\032)Tj 0 Tw (-)Tj 0.123 Tw T* (\027\t \002\t\021\034 \007\024\f\021\026\021\024\004\027\t\n\017 \007\035\ \016 \f\021\017\n\031\035\016\006\017\017 \023\030\024\021\017\r\024\r\024\ \f)Tj 0 Tw (-)Tj 0.183 Tw T* (\023\026\035\017\021\036\035\034\027\024\020\024 \220\235\235\036\022\021\ \026. \202\220\030\024\002\027\t\036 \031\023\030\026\032\027\036\027\017\ \016 \023\030\024)Tj 0 Tw (-)Tj 0.161 Tw T* (\007\024\035\032\017\021\036\035\034\027\024\f\021\034\033 \002\024\035\036\ \036 4 \027\036\007\036\035\034 \n\024\020\031\021 \002\t\021\034 \002\024\ \035\036\036 )Tj 0.264 Tw T* (\023\024\007\b\024\007\016\013\017\n\017 \007\035\016 \n\024\007\031\035\ \016\006\017\017 \f\017\n\023\021\024\n\024\r \031\f\021\026\035\024\f\021\ \017 )Tj 0.164 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\017\n\n\031\027\027\024\005 \f\017\f\021\036\n\t \031)Tj /Span<>> BDC ( )Tj EMC (\r\030\024\f\035\t\b \f)Tj /Span<>> BDC ( )Tj EMC (\027\036\026\022\021\017\r\027\t\n \017\035\017 )Tj 0.048 Tw T* (\031\n\036\030\036\027\027\024 \026\022\021\017\r\027\t\n \200\003\025, \ \004\036\n \031\023\030\026\032\027\036\027\017\016 \f)Tj /Span<>> BDC ( )Tj EMC (\024\021\016\020\024\013\036)Tj 0 Tw (-)Tj 0.005 Tw T* (\027\017\016\n\017, \022\024\021\024\030\t\n \n\024\032\036\021 \023\024\ \021\030\036\002\024\r\026\021\034\f\016 \002\024\035\036\036 \007\035\017\ \021\036\035\034)Tj 0 Tw (-)Tj 0.145 Tw T* (\027\026\016 \023\030\024\007\024\035\032\017\021\036\035\034\027\024\f\021\ \034, \004\021\024\002\t \r\t\r\026\021\034 \220\021\017 \031\035\031\004\ \001\036)Tj 0 Tw (-)Tj T* (\027\017\016 [54].)Tj 0.015 Tw T* [(\222\f\f\035\036\007\024\r\026\027\017\016 )0.6(\023\024\022\026\026\035\017, )0.5(\004\021\024 )0.5(\023\030\024\021\017\r\024\r\024\f\023\026\035\017\021\036\035\034\027\t\ \005 )]TJ 0.411 Tw T* (\030\036\031\035\034\021\026\021 \031\023\030\026\032\027\036\027\017\005\ \026\r\017\f\017\021 \024\021 FITT-\022\030\017\021\036\030\017\036\r \ )Tj 0.086 Tw T* [(\(F)10(r)-24(equency)]TJ /Span<>> BDC ( )Tj EMC 4.777 0 Td [(\227 )0.5(Intensi)-23.9(t)-10(y)]TJ /Span<>> BDC ( )Tj EMC 5.367 0 Td [(\227 )0.5(T)35(ime)]TJ /Span<>> BDC ( )Tj EMC 3.53 0 Td [(\227 )0.5(T)40(ype\), )0.5(\026)]TJ /Span<>> BDC ( )Tj EMC 4.808 0 Td [(\021\026\022\032\036 )0.5(\024\021 )]TJ 0.128 Tw -18.483 -1.218 Td (\022\024\035\017\004\036\f\021\r\026 \026\007\036\005\f\021\r\024\r\026\ \027\027\024\005 \n\t\001\036\004\027\024\005 \n\026\f\f\t [70]. )Tj 0.054 Tw T* (FITT-\022\030\017\021\036\030\017\017 \024\022\026\t\r\026\033\021 \023\ \030\016\n\024\036 \r\035\017\016\027\017\036 \027\026)Tj /Span<>> BDC ( )Tj EMC (\r\t\f\r\024)Tj 0 Tw (-)Tj T* (\002\024\032\007\036\027\017\036 \023\030\024\021\017\r\024\r\024\f\023\026\ \035\017\021\036\035\034\027\t\b \006\017\021\024\022\017\027\024\r [71]\ .)Tj 0.188 Tw T* [(E)15(ck)10(er)-21.9(t K.G. \f)]TJ /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. \023\030\036\007\f\021\026\r\035\016\033\021 \f\035\036\ \007\031\033\013\017\036 FITT-)Tj 0.07 Tw T* (\022\030\017\021\036\030\017\017 \023\024)Tj /Span<>> BDC ( )Tj EMC (\205\202 \007\035\016 \023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\200\003\025 \035\036\020\022\024\005 \017)Tj /Span<>> BDC ( )Tj EMC (\f\030\036\007)Tj 0 Tw (-)Tj T* (\027\036\005 \f\021\036\023\036\027\017 \021\016\032\036\f\021\017 [53]:\ )Tj 0.385 Tw T* (\226)Tj /Span<>> BDC [( )118( )]TJ EMC 1.056 0 Td [(F)10(r)-24(equency/\004\026\f\021\024\021\026)]TJ /Span<>> BDC ( )Tj EMC (\227 ...\026\027\017\n\026\005\021\036\f\034 \031\n\036\030\036\027\027\ \024\005 )Tj -0.007 Tw T* [(\235\017\022\031\035\034\021\031\030\024\005 )0.6(\n\017\027\017\n\031\n )0.5(\021\030\017 )0.6(\030\026\026 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 14.338 0 Td [(\027\036\007\036\035\033, )0.6(\026)]TJ /Span<>> BDC ( )Tj EMC 4.189 0 Td (\035\031\004\001\036 )Tj 0 Tw -18.527 -1.218 Td (\023\016\021\034 \030\026 \r)Tj /Span<>> BDC ( )Tj EMC (\027\036\007\036\035\033;)Tj 0.832 Tw -1.056 -1.218 Td (\226)Tj /Span<>> BDC [( )565( )]TJ EMC 1.056 0 Td [(Intensi)-23.9(t)-10(y/\017\027\021\036\027\f\017\r\027\024\f\021\034)]TJ /Span<>> BDC ( )Tj EMC 11.321 0 Td [(\227 )0.5(...\r\t\002\036\030\017\021\036 )0.5(\007\036\016)]TJ 0 Tw (-)Tj 0.281 Tw -11.321 -1.218 Td [(\021\036\035\034\027\024\f\021\034, )0.5(\022\024\021\024\030\026\016 \031\r\036\035\017\004\017\r\026\036\021 \030\ \026\f\b\024\007 \220\027\036\030\020\017\017, )]TJ 0.02 Tw T* (\023\024)Tj /Span<>> BDC ( )Tj EMC (\022\030\026\005\027\036\005 \n\036\030\036, \r)Tj /Span<>> BDC ( )Tj EMC (\021\030\017 \017\035\017 \004\036\021\t\030\036 \030\026\026, \022\026\ \022 \r)Tj /Span<>> BDC ( )Tj EMC (\f\035\031)Tj 0 Tw (-)Tj 0.037 Tw T* (\004\026\036 \f)Tj /Span<>> BDC ( )Tj EMC (\002\t\f\021\030\024\005 \b\024\007\034\002\024\005. \212\035\016 \022\024\ \027\021\030\024\035\016 \031\023\030\026\032\027\036\027\017\005 )Tj 0.028 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\023\024\n\024\013\034\033 \004\026\f\021\024\021\t \f\036\030\007\036\004\ \027\t\b \f\024\022\030\026\013\036\027\017\005 \017\027\021\036\027)Tj 0 Tw (-)Tj 0.114 Tw T* (\f\017\r\027\024\f\021\034 \031\023\030\026\032\027\036\027\017\005 \007\ \024\035\032\027\026 \f\024\f\021\026\r\035\016\021\034 60\22680% )Tj 0.077 Tw T* (\024\021 \n\026\022\f\017\n\026\035\034\027\024\005 \004\026\f\021\024\021\ \t \f\036\030\007\036\004\027\t\b \f\024\022\030\026\013\036\027\017\005\ . )Tj 0.003 Tw T* (\222\n\036\005\021\036 \r)Tj /Span<>> BDC ( )Tj EMC (\r\017\007\031: \031\n\036\030\036\027\027\026\016 \017\027\021\036\027\f\ \017\r\027\024\f\021\034 \016\r\035\016\036\021\f\016 )Tj 0 Tw T* (\022\035\033\004\024\n \022)Tj /Span<>> BDC ( )Tj EMC (\031\n\036\027\034\001\036\027\017\033 \r\024\f\023\026\035\036\027\017\016\ ;)Tj 0.342 Tw -1.056 -1.218 Td (\226)Tj /Span<>> BDC [( )75( )]TJ EMC 1.056 0 Td [(T)35(ime/\r\030\036\n\016)]TJ /Span<>> BDC ( )Tj EMC (\227 \246\026\027\017\n\026\005\021\036\f\034 \205\211 \027\036 \n\036\027\ \036\036 30 )Tj 0.253 Tw T* (\n\017\027\031\021 \r)Tj /Span<>> BDC ( )Tj EMC (\007\036\027\034 \(\002\024\035\034\001\036, \007\026\032\036 \035\031\004\ \001\036, \036\f\035\017 \r\t \017\b )Tj 0 Tw T* (\023\036\030\036\027\024\f\017\021\036\);)Tj 0.081 Tw -1.056 -1.218 Td (\226)Tj /Span<>> BDC [( )-186( )]TJ EMC 1.056 0 Td [(T)40(ype/\021\017\023)]TJ /Span<>> BDC ( )Tj EMC (\227 ...\026\027\017\n\026\021\034\f\016 \023\030\017\016\021\027\t\n \007\ \036\035\024\n, \004\021\024\002\t )Tj 0.11 Tw T* [(\023\024\r\t\f\017\021\034 \r\036\030\024\016\021\027\024\f\021\034 )0.5(\f\024\b\030\026\027\036\027\017\016 \021\026\022\024\020\024 \023\024\r\ \036\007\036)]TJ 0 Tw (-)Tj -0.025 Tw T* (\027\017\016. \003\026\027\016\021\017\016 \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\026\b \n\024\020\031\021 \023\024\r\t\f\017\021\034\ \n\024\021\017\r\026\006\017\033. )Tj 0.402 Tw T* (\221\024\004\036\021\026\027\017\036 \031\023\030\026\032\027\036\027\017\ \005 \027\026)Tj /Span<>> BDC ( )Tj EMC (\r\t\027\024\f\035\017\r\024\f\021\034 \017)Tj /Span<>> BDC ( )Tj EMC (\f\024)Tj 0 Tw (-)Tj 0.201 Tw T* (\023\030\024\021\017\r\035\036\027\017\036 \016\r\035\016\036\021\f\016 \ \002\035\026\020\024\023\030\017\016\021\027\t\n, \023\024\f\022\024\035\ \034\022\031 )Tj 0.379 Tw T* [(\023\024\r\024\035\016\036\021 )0.6(\017\002\036\032\026\021\034 )0.5(\024\007\027\024\f\021\024\030\024\027\027\036\005 )0.6(\021\030\036\027\017\030\024\r\022\017 )]TJ 0.311 Tw 23.244 64.543 Td (\017)Tj /Span<>> BDC ( )Tj EMC [(\007\036\035\026\036\021 )0.5(\031\023\024\030 \027\026)]TJ /Span<>> BDC ( )Tj EMC 8.361 0 Td [(\017\f\023\024\035\034\024\r\026\027\017\036 )0.5(\r\f\036\b )0.5(\002\024\035\034\001\017\b )]TJ 0 Tw -8.361 -1.218 Td (\020\030\031\023\023 \n\t\001\006;)Tj 0.078 Tw -1.056 -1.218 Td (\226)Tj /Span<>> BDC [( )-189( )]TJ EMC 1.056 0 Td [(... )0.5(\031\r\036\035\017\004\017\021\034 )0.6(\022\024\035\017\004\036\f\021\r\024 )0.6(\f\r\024\002\024\007\027\024\020\024 )0.5(\r\030\036\n\036\027\017 )0.5(\007\035\016 )]TJ 0 Tw T* (\205\202. \253\222\007\017, \023\030\036\032\007\036 \004\036\n \002\036\ \032\026\021\034\273.)Tj 0.129 Tw -1.056 -1.218 Td [(\210\004\036\r\017\007\027\024, \004\021\024 \002\031\007\031\013\017\036\ \017\f\f\035\036\007\024\r\026\027\017\016, )0.5(\023\024\f\r\016\013\036\027\027\t\036 )]TJ -0.01 Tw T* (\022\030\017\021\036\030\017\016\n FIIT, \027\036\024\002\b\024\007\017\n\ \t \007\035\016 \023\030\024\r\036\030\022\017 \220\021\017\b \030\036\022\ \024)Tj 0 Tw (-)Tj 0.132 Tw 0 -1.218 TD (\n\036\027\007\026\006\017\005 \031)Tj /Span<>> BDC ( )Tj EMC (\r\030\024\f\035\t\b \f)Tj /Span<>> BDC ( )Tj EMC (\200\003\025, \021\026\022 \022\026\022 \f\035\036\007\031\036\021 \031\004\ \017\021\t)Tj 0 Tw (-)Tj 0.157 Tw 0 -1.218 TD (\r\026\021\034 \023\024\007\b\024\007 \253\007\024\026-\220\235\235\036\ \022\021\273 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\030\026\f\f\n\024\021\030\036\027\017\017 \021\017\023\026 )Tj 0 Tw T* (\031\023\030\026\032\027\036\027\017\005, \017\027\021\036\027\f\017\r\027\ \024\f\021\017 \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\007\024\035\032\017\021\036\035\034\027\024\f\021\017.)Tj 0.153 Tw T* [(\200 \n\036\021\026\026\027\026\035\017 Bak)10(er K.A. \017)]TJ /Span<>> BDC ( )Tj EMC (\f\024\026\r\021\024\030\024\r, \023\024\f\r\016\013\036\027\027\t\005 )Tj 0.215 Tw T* (\017\031\004\036\027\017\033 \220\235\235\036\022\021\017\r\027\024\f\021\ \017 \r\n\036\001\026\021\036\035\034\f\021\r \f)Tj /Span<>> BDC ( )Tj EMC (\205\211 \r)Tj /Span<>> BDC ( )Tj EMC (\024\021)Tj 0 Tw (-)Tj 0.023 Tw T* (\027\024\001\036\027\017\017 \r\024\f\023\026\035\017\021\036\035\034\027\ \024\005 \030\036\026\022\006\017\017 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\200\003\025, \017-\026 \027\036)Tj 0 Tw (-)Tj 0.065 Tw 0 -1.218 TD (\f\024\024\021\r\036\021\f\021\r\017\005 \f)Tj /Span<>> BDC ( )Tj EMC (\017\n\036\030\036\027\027\t\n\017 \n\026\030\022\036\030\026\n\017 \r\024\ \f\023\026\035\036\027\017\016 )Tj 0.285 Tw 0 -1.218 TD [(\n\027\024\020\017\b )0.6(\017\f\f\035\036\007\031\036\n\t\b )0.5(\030\026\002\024\021 )0.5(\002\t\035\024 )0.5(\r\022\035\033\004\036\027\024 )0.6(\021\024\035\034\022\024 )]TJ 0.126 Tw 0 -1.218 TD (4)Tj /Span<>> BDC ( )Tj EMC (\017\f\f\035\036\007\024\r\026\027\017\016. \204\036\021\026\026\027\026\ \035\017 \023\024\022\026\026\035, \004\021\024 \f\017\n\023\021\024\n\ \t )Tj 0.012 Tw T* (\f\024 \f\021\024\030\024\027\t \022\017\001\036\004\027\017\022\026 \024\ \f\035\026\002\036\r\026\035\017 \023\024\f\035\036 \030\036\020\031\035\ \016\030\027\t\b )Tj 0.061 Tw T* (\031\n\036\030\036\027\027\t\b \205\211. \215\030\017)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\n \205\211 \n\024\020\031\021 \027\036 \r\035\017\016\021\034\ \027\026)Tj /Span<>> BDC ( )Tj EMC (\n\026\030)Tj 0 Tw (-)Tj 0.077 Tw T* (\022\036\030\t \r\024\f\023\026\035\036\027\017\016 \(IL-6, TNF-\263, \221\ \217\207, IL-17, \035\036\005\022\024\006\017\021\t )Tj 0.037 Tw T* (\017\035\017 \035\017\n\235\024\006\017\021\t\) \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\200\003\025 \(\002\036 \n\036\007\017\022\026\n\036\027\021\024\027\024\ \020\024 \035\036)Tj 0 Tw (-)Tj -0.002 Tw T* (\004\036\027\017\016\) [30]. \210\020\030\026\027\017\004\036\027\027\024\ \036 \022\024\035\017\004\036\f\021\r\024 \017\f\f\035\036\007\024\r\026\ \027\017\005 )Tj 0.106 Tw T* [(\n\024\032\036\021 )0.5(\f\027\017\017\021\034 )0.6(\027\026\007\036\032\027\024\f\021\034 )0.6(\030\036\031\035\034\021\026\021\024\r, )0.5(\220\021\024 )0.5(\023\024\007\004\036\030)]TJ 0 Tw (-)Tj 0.31 Tw T* [(\022\017\r\026\036\021 )0.5(\027\036\024\002\b\024\007\017\n\024\f\021\034 )0.5(\007\024\023\024\035\027\017\021\036\035\034\027\t\b )0.6(\017\f\f\035\036\007\024\r\026)]TJ 0 Tw (-)Tj 0.111 Tw T* (\027\017\005 \r)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\005 \024\002\035\026\f\021\017. \200\026\032\027\024 \024\021\ \n\036\021\017\021\034, \004\021\024 \024\021\f\031\021\f\021\r\017\036 \ )Tj 0.192 Tw T* (\027\036\002\035\026\020\024\023\030\017\016\021\027\t\b \f\017\n\023\021\ \024\n\026\021\017\004\036\f\022\017\b \030\036\026\022\006\017\005 \027\ \026)Tj /Span<>> BDC ( )Tj EMC (\205\211 )Tj 0.225 Tw T* (\031\022\026\t\r\026\036\021 \027\026)Tj /Span<>> BDC ( )Tj EMC (\021\024, \004\021\024 \205\211 \002\036\024\023\026\f\027\t \007\035\016\ \023\026\006\017\036\027\021\024\r )Tj 0 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\200\003\025 [30].)Tj 0.444 Tw T* (\212\024\022\026\026\021\036\035\034\f\021\r\026, \023\024\007\021\r\036\ \030\032\007\026\033\013\017\036 \022\024\027\022\030\036\021\027\t\036 \ \030\036)Tj 0 Tw (-)Tj 0.134 Tw T* (\022\024\n\036\027\007\026\006\017\017 \023\024)Tj /Span<>> BDC ( )Tj EMC (\031\023\030\026\032\027\036\027\017\016\n, \r\022\035\033\004\026\016 \021\ \026\022\017\036 \026\f\023\036\022)Tj 0 Tw (-)Tj 0.311 Tw T* (\021\t, \022\026\022 \023\030\024\007\024\035\032\017\021\036\035\034\027\ \024\f\021\034 \017)Tj /Span<>> BDC ( )Tj EMC (\006\036\035\036\r\t\036 \023\024\022\026\026\021\036\035\017 )Tj 0.429 Tw T* [(\004\026\f\021\024\021\t \f\036\030\007\036\004\027\t\b )0.5(\f\024\022\030\026\013\036\027\017\005, \027\036\024\002\b\024\007\017\n\ \t \007\035\016 )]TJ 0.039 Tw T* (\021\024\020\024, \004\021\024\002\t \035\031\004\001\036 \022\024\027\f\ \031\035\034\021\017\030\024\r\026\021\034 \023\026\006\017\036\027\021\024\ \r \f)Tj /Span<>> BDC ( )Tj EMC (\200\003\025. )Tj 0.337 Tw T* (\215\024\007\007\036\030\032\026\027\017\036 \235\017\017\004\036\f\022\ \017 \026\022\021\017\r\027\024\020\024 \024\002\030\026\026 \032\017\027\ \017 )Tj 0.218 Tw T* (\016\r\035\016\036\021\f\016 \024\f\027\024\r\027\024\005 \006\036\035\034\ \033 \r\f\036\b \035\036\004\036\002\027\t\b \n\036\030\024\023\030\017)Tj 0 Tw (-)Tj 0.133 Tw T* [(\016\021\017\005. )0.5(\203\036\024\002\b\024\007\017\n\024 )0.5(\r\027\036\007\030\017\021\034 )0.5(\n\036\021\024\007\t )0.6(\007\035\016 )0.5(\023\024\r\t\001\036\027\017\016 )]TJ 0.16 Tw T* (\n\024\021\017\r\026\006\017\017, \f\026\n\024\030\036\020\031\035\016\006\ \017\017 \017)Tj /Span<>> BDC ( )Tj EMC (\f\026\n\024\030\036\235\035\036\022\f\017\017, \004\021\024\002\t )Tj 0.065 Tw T* [(\023\026\006\017\036\027\021\t )0.5(\n\024\020\035\017 )0.6(\023\030\017\n\036\027\016\021\034 )0.5(\205\202 )0.5(\007\035\016 )0.5(\017\027\007\017\r\017\007\031\026\035\034\027\024\020\024 )]TJ 0 Tw T* (\035\036\004\036\027\017\016 \f\r\024\036\020\024 \026\002\024\035\036\r\ \026\027\017\016.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 275.0305 249.8878 Tm [(\020)21(\026\027\r\242\224\034\022\031\034)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf 0 Tc 0.08 Tw 10 0 0 10 274.9606 225.5318 Tm (\230\026\022\017\n \024\002\030\026\024\n, \f)Tj /Span<>> BDC ( )Tj EMC (\023\024\017\006\017\017 \007\024\022\026\026\021\036\035\034\027\024\005\ \n\036\007\017\006\017\027\t, )Tj 0.055 Tw T* (\023\030\024\r\036\007\201\027\027\t\036 \007\024)Tj /Span<>> BDC ( )Tj EMC (2022 \020\024\007\026 \017\f\f\035\036\007\024\r\026\027\017\016 \023\030\ \036\007\024\f\021\026\r)Tj 0 Tw (-)Tj 0.147 Tw T* (\035\016\033\021 \035\017\001\034 \023\030\036\007\r\026\030\017\021\036\ \035\034\027\t\036 \007\026\027\027\t\036 \024)Tj /Span<>> BDC ( )Tj EMC (\023\024\035\024\032\017\021\036\035\034)Tj 0 Tw (-)Tj 0.214 Tw T* (\027\024\n \r\035\017\016\027\017\017 \031\023\030\026\032\027\036\027\017\ \005 \027\026)Tj /Span<>> BDC ( )Tj EMC (\007\024\030\024\r\034\036 \022\024\f\021\036\005, \n\t)Tj 0 Tw (-)Tj 0.422 Tw T* [(\001\036\004\027\031\033 )0.5(\235\031\027\022\006\017\033, )0.5(\023\f\017\b\024\035\024\020\017\004\036\f\022\024\036 )0.5(\002\035\026\020\024\023\024\035\031\004\017\036, )]TJ 0.266 Tw T* (\031\021\024\n\035\016\036\n\024\f\021\034, \022\026\030\007\017\024\030\ \036\f\023\017\030\026\021\024\030\027\031\033 \r\t\027\024\f\035\017\r\024\ \f\021\034, )Tj 0.322 Tw T* (\f\024\f\021\026\r \021\036\035\026, \017\n\n\031\027\027\t\036 \023\026\ \030\026\n\036\021\030\t \017)Tj /Span<>> BDC ( )Tj EMC (\r\024\f\023\026\035\017\021\036\035\034)Tj 0 Tw (-)Tj 0.23 Tw T* (\027\t\036 \002\017\024\n\026\030\022\036\030\t [54]. \210\007\027\026\022\ \024 \020\017\023\024\021\036\026 \024)Tj /Span<>> BDC ( )Tj EMC (\r\035\017\016\027\017\017 )Tj 0.098 Tw T* (\205\202 \027\026)Tj /Span<>> BDC ( )Tj EMC 2.823 0 Td [(\023\026\021\024\020\036\027\027\t\036 )0.5(\r\036\027\034\016 \002\024\035\034\001\017\027\f\021\r\026 \216\203\222\ \003 )0.5(\023\024\035\027\024)]TJ 0 Tw (-)Tj 0.212 Tw -2.823 -1.218 Td (\f\021\034\033 \023\024\007\021\r\036\030\032\007\036\027\026: \205\211 \ \f\023\024\f\024\002\027\t \n\024\007\017\235\017\006\017\030\024\r\026\021\ \034 )Tj 0.25 Tw T* (\r\024\f\023\026\035\017\021\036\035\034\027\t\005 \f\021\026\021\031\f \ \f\031\002\255\036\022\021\026 \026)Tj /Span<>> BDC ( )Tj EMC (\f\004\036\021 \f\027\017\032\036\027\017\016 )Tj 0.086 Tw T* [(\031\030\024\r\027\036\005 \023\030\024\r\024\f\023\026\035\017\021\036\035\ \034\027\t\b )0.5(\006\017\021\024\022\017\027\024\r, \r\022\035\033\004\026\016 IL-)]TJ 0.235 Tw T* (1, IL-6 \017)Tj /Span<>> BDC ( )Tj EMC (TNF-\263. \222\f\f\035\036\007\024\r\026\027\017\016 \007\026\033\021 \031\ \002\036\007\017\021\036\035\034\027\t\036 )Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 0 Tw 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\214)10(\211\036\033 \035\030\032\t\033)30(\b)42(\032)-21(\240\033\233)]TJ 57.136 0 Td (REVIEW)Tj /T1_4 1 Tf 25 0 0 25 505.5021 56.0378 Tm (157)Tj ET endstream endobj 491 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.278 Tw 10 0 0 10 70.8661 724.8299 Tm (\022\026\004\036\f\021\r\026 \032\017\027\017, \r\035\017\016\027\017\036\ \205\211 \027\026)Tj /Span<>> BDC ( )Tj EMC (\n\t\001\036\004\027\031\033 \026\022\021\017\r)Tj 0 Tw (-)Tj 0.194 Tw 0 -1.218 TD (\027\024\f\021\034 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\200\003\025 \016\r\035\016\036\021\f\016 \027\026\017\n\036\027\036\036\ \017\031\004\036\027\027\t\n [42]. )Tj 0.133 Tw T* [(\217\016\007 )0.5(\017\f\f\035\036\007\024\r\026\027\017\005 )0.6(\031\022\026\t\r\026\033\021 )0.5(\027\026)]TJ /Span<>> BDC ( )Tj EMC [(\031\035\031\004\001\036\027\017\036 )0.6(\n\t\001\036\004)]TJ 0 Tw (-)Tj 0.014 Tw T* (\027\024\005 \f\017\035\t \023\024\f\035\036 \r\n\036\001\026\021\036\035\ \034\f\021\r \f)Tj /Span<>> BDC ( )Tj EMC (\205\211 [39,53], \017)Tj /Span<>> BDC ( )Tj EMC (\023\024\007\004\036\030)Tj 0 Tw (-)Tj 0.154 Tw T* (\022\017\r\026\036\021\f\016 \023\024\021\036\027\006\017\026\035 \031\023\ \030\026\032\027\036\027\017\005 \007\035\016 \027\026\004\017\021\036\035\ \034\027\024\020\024 )Tj 0.079 Tw T* [(\031\035\031\004\001\036\027\017\016 )0.6(\n\t\001\036\004\027\024\005 )0.5(\r\t\027\024\f\035\017\r\024\f\021\017 )0.6(\r\036\030\b\027\017\b )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 20.071 0 Td (\027\017\032)Tj 0 Tw (-)Tj -0.001 Tw -20.071 -1.218 Td [(\027\017\b )0.5(\022\024\027\036\004\027\024\f\021\036\005 )0.5([54]. )0.5(\224\021\017 )0.5(\007\026\027\027\t\036 )0.5(\031\022\026\t\r\026\033\021 )0.6(\027\026)]TJ /Span<>> BDC ( )Tj EMC 20.163 0 Td (\r\026\032)Tj 0 Tw (-)Tj 0.089 Tw -20.163 -1.218 Td [(\027\024\f\021\034 )0.5(\r\t\016\r\035\036\027\017\016 )0.5(\n\t\001\036\004\027\024\005 )0.6(\f\035\026\002\024\f\021\017 )0.5(\031)]TJ /Span<>> BDC ( )Tj EMC 16.838 0 Td [(\035\033\007\036\005 )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC 3.71 0 Td (\200\003\025 )Tj 0.022 Tw -20.548 -1.218 Td (\r)Tj /Span<>> BDC ( )Tj EMC (\030\026\n\022\026\b \023\024\r\f\036\007\027\036\r\027\024\005 \022\035\ \017\027\017\004\036\f\022\024\005 \023\024\n\024\013\017 \017)Tj /Span<>> BDC ( )Tj EMC (\017\027\021\036)Tj 0 Tw (-)Tj 0.052 Tw T* (\020\030\026\006\017\017 \r\n\036\001\026\021\036\035\034\f\021\r \f)Tj /Span<>> BDC ( )Tj EMC [(\205\211 \007\035\016 \035\036\004\036\027\017\016 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC (\023\030\036\007\024\021\r\030\026)Tj 0 Tw (-)Tj 0.33 Tw T* [(\013\036\027\017\016 )0.5(\030\026\r\017\021\017\016 )0.6(\f\022\036\035\036\021\027\024-\n\t\001\036\004\027\t\b )0.6(\r\027\036\022\017\001\036\004\027\t\b )]TJ 0 Tw T* (\023\030\024\016\r\035\036\027\017\005.)Tj 0.072 Tw 0 -1.218 TD (\210\023\017\f\026\027\024 \r\035\017\016\027\017\036 \205\202 \027\026)Tj /Span<>> BDC ( )Tj EMC (\007\030\031\020\017\036 \f\017\n\023\021\024\n\t \200\003\025. \207\t\035\ \024 )Tj 0.265 Tw 0 -1.218 TD (\024\021\n\036\004\036\027\024, \004\021\024 \205\211 \023\030\017\r\024\ \007\016\021 \022)Tj /Span<>> BDC ( )Tj EMC (\031\035\031\004\001\036\027\017\033 \027\026\f\021\030\024\036)Tj 0 Tw (-)Tj 0.38 Tw 0 -1.218 TD [(\027\017\016 [37,55,56], \031\035\031\004\001\026\033\021 )0.5(\023\f\017\b\024\035\024\020\017\004\036\f\022\024\036 )0.5(\007\024\030\024)]TJ 0 Tw (-)Tj 0.081 Tw T* (\r\034\036, \f\023\024\f\024\002\027\024\f\021\034 \f\023\030\026\r\035\016\ \021\034\f\016 \f\024 \f\021\030\036\f\f\024\n, \031\n\036\027\034\001\026\ )Tj 0 Tw (-)Tj 0.151 Tw T* [(\033\021 )0.5(\021\030\036\r\024\020\031 )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC 5.861 0 Td [(\007\036\023\030\036\f\f\017\033 )0.5(\023\030\017)]TJ /Span<>> BDC ( )Tj EMC 6.787 0 Td [(\200\003\025 )0.5([39,57], )0.6(\031\035\031\004\001\026\033\021 )]TJ 0.393 Tw -12.648 -1.218 Td (\f\026\n\024\004\031\r\f\021\r\017\036 \(\031\035\031\004\001\036\027\017\ \036 \220\027\036\030\020\017\017\), \022\026\004\036\f\021\r\024 \f\027\ \026, )Tj 0.233 Tw T* (\031\n\036\027\034\001\026\033\021 \022\024\035\017\004\036\f\021\r\024 \ \032\036\035\031\007\024\004\027\024-\022\017\001\036\004\027\t\b \f\017\ \n\023)Tj 0 Tw (-)Tj T* (\021\024\n\024\r [55,56,58,59].)Tj /T1_1 1 Tf 0.023 Tw 0 -2.436 TD (\203\032 \t)Tj /Span<>> BDC ( )Tj EMC (\006\t\217\220 \006\r\204\t\240\t\002 \026\033\021)Tj /T1_0 1 Tf 0.224 Tw 0 -1.218 TD (\205\211 \f\r\016\026\027\t \002\024\035\036\036 \027\017\022\024\005 \ \004\026\f\021\024\021\024\005 \030\036\006\017\007\017\r\024\r \022\026\ \022 )Tj 0.12 Tw T* (\031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\247\025, \021\026\022 \017)Tj /Span<>> BDC ( )Tj EMC (\031 \023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\207\025. \200)Tj /Span<>> BDC ( )Tj EMC (\035\024\027\020\017)Tj 0 Tw (-)Tj 0.067 Tw T* (\021\033\007\027\024\005 \024\006\036\027\022\036 \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\030\036\n\017\f\f\017\036\005 \207\025 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\r\t)Tj 0 Tw (-)Tj 0.155 Tw T* (\023\024\035\027\036\027\017\017 \002\024\035\036\036 \r\t\f\024\022\024\ \005 \205\203, \r\036\030\024\016\021\027\024\f\021\034 \030\026\r\017\021\ \017\016 )Tj 0.203 Tw T* (\026\022\021\017\r\027\024\020\024 \026\002\024\035\036\r\026\027\017\016\ \004\036\030\036 6 \n\036\f\016\006\036\r \002\t\035\026 \027\026)Tj 0 Tw (-)Tj 0.092 Tw T* (\004\017\021\036\035\034\027\024 \027\017\032\036 \()Tj /T1_2 1 Tf 0 Tw (P)Tj /T1_0 1 Tf 0.092 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,02\). \211)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\247\025 \017\035\017 \022\024)Tj 0 Tw (-)Tj 0.421 Tw T* [(\035\017\021\024\n \027\036\024\023\030\036\007\036\035\036\027\027\024\020\ \024 )0.5(\023\030\024\017\f\b\024\032\007\036\027\017\016 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC (\f\021\026\007\017\017 )Tj 0.059 Tw T* (\030\036\n\017\f\f\017\017, \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\036\036 \r\t\f\024\022\017\n \031\030\024\r\027\036\n \205\203\ )Tj 0.144 Tw T* (\r\036\030\024\016\021\027\024\f\021\034 \030\026\r\017\021\017\016 \026\ \022\021\017\r\027\024\020\024 \026\002\024\035\036\r\026\027\017\016 \004\ \036\030\036 )Tj 0.191 Tw T* (6 \n\036\f\016\006\036\r \002\t\035\026 \027\017\032\036; \024\007\027\026\ \022\024 \220\021\024 \027\036 \002\t\035\024 \f\021\026\021\017\f)Tj 0 Tw (-)Tj 0.29 Tw T* (\021\017\004\036\f\022\017 \027\026\004\017\n\t\n [60]. \203\036\002\024\ \035\034\001\024\036 \017\f\f\035\036\007\024\r\026\027\017\036, )Tj 0.112 Tw T* [(\r\022\035\033\004\026\033\013\036\036 )0.5(15)]TJ /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r)Tj /Span<>> BDC ( )Tj EMC (\227 \f)Tj /Span<>> BDC ( )Tj EMC (\207\025 \017)Tj /Span<>> BDC ( )Tj EMC (15 \004\036\035\024\r\036\022)Tj /Span<>> BDC ( )Tj EMC 21.11 0 Td (\227 )Tj 0.393 Tw -21.11 -1.218 Td (\017)Tj /Span<>> BDC ( )Tj EMC (\022\024\027\021\030\024\035\034\027\024\005 \020\030\031\023\023\t, \023\ \024\022\026\026\035\024, \004\021\024 \023\024\007\030\024\f\021\022\017\ )Tj 0.148 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\207\025 \n\024\020\031\021 \r\t\023\024\035\027\016\021\034 \f\024\r\036\ \030\001\036\027\027\024 \030\026\027\t\036 \r\017\007\t \205\211 )Tj 0.267 Tw T* (\(\027\036\023\030\036\030\t\r\027\t\036 \031\023\030\026\032\027\036\027\ \017\016 \f\030\036\007\027\036\005 \017\027\021\036\027\f\017\r\027\024\ \f\021\017 )Tj 0.024 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC [(\023\030\036\030\t\r\017\f\021\t\036 \031\023\030\026\032\027\036\027\017\ \016 )0.5(\r\t\f\024\022\024\005 \017\027\021\036\027\f\017\r\027\024\f\021\017\) \ )]TJ 0.063 Tw T* [(\002\036 )0.5(\027\026\004\017\021\036\035\034\027\024\020\024 )0.6(\024\002\024\f\021\030\036\027\017\016 )0.6(\026\002\024\035\036\r\026\027\017\016. )0.5(\211)]TJ /Span<>> BDC ( )Tj EMC 19.768 0 Td (\023\026\006\017)Tj 0 Tw (-)Tj 0.061 Tw -19.768 -1.218 Td [(\036\027\021\024\r )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC [(\207\025 )0.5(\024\002\026 \021\017\023\026 )0.5(\205\211 )0.5(\031\r\036\035\017\004\017\r\026\035\017 )0.5(\022\024\035\017\004\036\f\021\r\024 )0.5(\017\n)]TJ 0 Tw (-)Tj 0.141 Tw T* [(\n\031\027\027\t\b )0.6(\022\035\036\021\024\022 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 7.48 0 Td [(\020\024\030\n\024\027\026 )0.5(\030\024\f\021\026 )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC 7.337 0 Td [(\f\027\017\032\026\035\017 )0.6(\031\030\024\r\036\027\034 )]TJ -0.021 Tw -14.818 -1.218 Td (IGF-I. TNF-\263 \f\031\013\036\f\021\r\036\027\027\024 \027\036 \017\n\036\ \027\017\035\f\016 \027\017 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\024\007\027\024\n )Tj 0.109 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC 1.286 0 Td [(\031\023\030\026\032\027\036\027\017\005 )0.6([28]. )0.5(\207\024\035\034\001\036 )0.5(\205\202 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 13.606 0 Td [(\f\r\024\002\024\007\027\024\036 )0.5(\r\030\036\n\016 )]TJ 0.105 Tw -14.893 -1.218 Td (\017)Tj /Span<>> BDC ( )Tj EMC (\205\211, \027\036 \r\t\t\r\026\033\013\017\036 \023\024\021\024\024\021\ \007\036\035\036\027\017\016, \002\t\035\017 \f\r\016\026\027\t )Tj -0.014 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\031\035\031\004\001\036\027\017\036\n \022\026\004\036\f\021\r\026 \032\ \017\027\017 \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\200\003\025 \(158 )Tj 0 Tw T* (\023\026\006\017\036\027\021\024\r\) [61].)Tj 0.903 Tw T* (\025\030\024\f\f-\f\036\022\006\017\024\027\027\024\036 \023\024\023\031\ \035\016\006\017\024\027\027\024\036 \017\f\f\035\036\007\024\r\026\027\017\ \036 )Tj 0.207 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\r\024\f\021\024\004\027\024\005 \216\024\030\r\026\021\017\017, \r\022\035\ \033\004\026\033\013\036\036 312 \023\026\006\017\036\027\021\024\r )Tj 0.213 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\200\003\025, \023\024\022\026\026\035\024, \004\021\024 \036\032\036\007\ \027\036\r\027\026\016 \205\202 \002\t\035\026 \f\r\016\026\027\026 )Tj 0.092 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\024\021\f\031\021\f\021\r\017\036\n \026\022\021\017\r\027\024\f\021\017\ \200\003\025 \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r, \027\036 \023\024\035\031)Tj 0 Tw (-)Tj 0.112 Tw T* (\004\026\033\013\017\b \021\036\030\026\023\017\033, \027\026)Tj /Span<>> BDC ( )Tj EMC (\024\f\027\024\r\026\027\017\017 \004\036\020\024 \026\r\021\024\030\t \007\ \036\035\026\033\021 )Tj 0.03 Tw T* (\r\t\r\024\007 \024)Tj /Span<>> BDC ( )Tj EMC (\027\036\024\002\b\024\007\017\n\024\f\021\017 \017\027\235\024\030\n\017\ \030\024\r\026\027\017\016 \r\f\036\b \023\026\006\017)Tj 0 Tw (-)Tj 0.073 Tw T* (\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\200\003\025 \024)Tj /Span<>> BDC ( )Tj EMC (\r\026\032\027\024\f\021\017 \205\202 \007\035\016 \022\024\027\021\030\024\ \035\016 \017\b \026\002\024\035\036)Tj 0 Tw (-)Tj T* (\r\026\027\017\016 [62].)Tj 0.258 Tw 23.244 64.543 Td (\200\t\f\024\022\024\017\027\021\036\027\f\017\r\027\t\036 \017\027\021\036\ \030\r\026\035\034\027\t\036 \021\030\036\027\017\030\024\r\022\017 \017\ \035\017 )Tj 0.79 Tw T* [(\027\036\023\030\036\030\t\r\027\t\036 )0.6(\021\030\036\027\017\030\024\r\022\017 )0.5(\f\030\036\007\027\036\005 )0.6(\017\027\021\036\027\f\017\r\027\024)]TJ 0 Tw (-)Tj 0.096 Tw T* (\f\021\017 \(\021\030\017 \021\030\036\027\017\030\024\r\022\017 \r)Tj /Span<>> BDC ( )Tj EMC (\027\036\007\036\035\033 \r)Tj /Span<>> BDC ( )Tj EMC (\021\036\004\036\027\017\036 12 \027\036\007\036\035\034\) )Tj 0.1 Tw T* (\031)Tj /Span<>> BDC ( )Tj EMC (\r\030\024\f\035\t\b \f)Tj /Span<>> BDC ( )Tj EMC (\207\025 \023\024\022\026\026\035\017 \f\030\036\007\027\036\036 \f\027\ \017\032\036\027\017\036 \024\002\013\036\005 )Tj 0.275 Tw T* (\031\021\024\n\035\016\036\n\024\f\021\017 \023\024)Tj /Span<>> BDC ( )Tj EMC (\f\030\026\r\027\036\027\017\033 \f)Tj /Span<>> BDC ( )Tj EMC (\017\f\b\024\007\027\t\n \031\030\024\r\027\036\n. )Tj 0.139 Tw T* (\211)Tj /Span<>> BDC ( )Tj EMC (2 \031\004\026\f\021\027\017\022\024\r \(\017 53\) \r\024 \r\030\036\n\016\ \023\024\f\035\036\007\031\033\013\036\020\024 \027\026)Tj 0 Tw (-)Tj 0.246 Tw 0 -1.218 TD (\002\035\033\007\036\027\017\016 \026\235\017\022\f\017\030\024\r\026\027\ \030\036\006\017\007\017\r. \202\r\021\024\030\t \f\007\036\035\026\035\ \017 )Tj 0.102 Tw 0 -1.218 TD (\r\t\r\024\007, \004\021\024 \205\211 \016\r\035\016\033\021\f\016 \023\024\ \021\036\027\006\017\026\035\034\027\024 \023\024\035\036\027\024\005 \007\ \024)Tj 0 Tw (-)Tj 0.019 Tw T* (\023\024\035\027\017\021\036\035\034\027\024\005 \021\036\030\026\023\017\ \036\005 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\207\025 [63]. \215\026\006\017\036\027\021\t \f)Tj /Span<>> BDC ( )Tj EMC (\200\003\025 )Tj 0.073 Tw T* (\027\036 \007\024\035\032\027\t \017\002\036\020\026\021\034 \031\023\030\ \026\032\027\036\027\017\005 \017-\026 \024\023\026\f\036\027\017\016 \ \030\036)Tj 0 Tw (-)Tj 0.016 Tw T* (\006\017\007\017\r\024\r, \017\b \027\031\032\027\024 \n\024\021\017\r\017\ \030\024\r\026\021\034 \027\026)Tj /Span<>> BDC ( )Tj EMC (\030\036\020\031\035\016\030\027\t\036 \031\n\036)Tj 0 Tw (-)Tj T* (\030\036\027\027\t\036 \205\203 [64].)Tj /T1_1 1 Tf -0.04 Tw 0 -2.436 TD (\035\t\214\t\003\t\006\210\211\227\t\r \226\004\220\003\002\006\013 \240\ \f\235 \203\032 \210)Tj /Span<>> BDC ( )Tj EMC (\212\004\204\t\r\b\003\002 \217)Tj /Span<>> BDC ( )Tj EMC (\026\033\021)Tj /T1_0 1 Tf 0.29 Tw 0 -1.218 TD (\221\031\013\036\f\021\r\031\036\021 \n\027\024\020\024 \023\024\021\036\ \027\006\017\026\035\034\027\t\b \023\030\036\023\016\021\f\021\r\017\005\ \007\035\016 )Tj -0.002 Tw T* (\205\211 \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\200\003\025. \025)Tj /Span<>> BDC ( )Tj EMC (\027\017\n \024\021\027\024\f\016\021\f\016 \031\021\024\n\035\016\036\n\ \024\f\021\034, )Tj -0.028 Tw T* (\002\024\035\034 \r)Tj /Span<>> BDC ( )Tj EMC [(\f\031\f\021\026\r\026\b, \f\r\016\026\027\027\026\016 )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC (\026\030\021\030\017\021\024\n \017\035\017 \026\030\021\030\024\023\026\ \021\017)Tj 0 Tw (-)Tj 0.026 Tw T* (\036\005, \002\024\035\034 \r)Tj /Span<>> BDC ( )Tj EMC (\032\017\r\024\021\036, \007\017\026\030\036\016 \017\035\017 \017\n\023\ \036\030\026\021\017\r\027\t\036 \023\024\t\r\t )Tj -0.016 Tw T* (\022)Tj /Span<>> BDC ( )Tj EMC (\007\036\235\036\022\026\006\017\017 [65], \026\022\021\017\r\027\024\036\ \026\002\024\035\036\r\026\027\017\036 \017)Tj /Span<>> BDC ( )Tj EMC (\007\036\023\030\036\f\f\017\016 )Tj 0.201 Tw T* ([9]. \203\036\002\035\026\020\024\023\030\017\016\021\027\t\036 \f\024\002\ \t\021\017\016 \r\024\n\024\032\027\t \r)Tj /Span<>> BDC ( )Tj EMC (\030\036\007\022\017\b )Tj 0.178 Tw T* (\f\035\031\004\026\016\b. \200)Tj /Span<>> BDC ( )Tj EMC (\n\036\021\026\026\027\026\035\017\036 2022 \020\024\007\026 \253\200\035\ \017\016\027\017\036 \f\021\030\031\022)Tj 0 Tw (-)Tj 0.105 Tw T* (\021\031\030\017\030\024\r\026\027\027\t\b \023\030\024\020\030\026\n\n \ \031\023\030\026\032\027\036\027\017\005 \027\026)Tj /Span<>> BDC ( )Tj EMC (\235\017\017\024\035\024\020\017)Tj 0 Tw (-)Tj 0.036 Tw T* (\004\036\f\022\017\036 \017)Tj /Span<>> BDC ( )Tj EMC (\023\f\017\b\024\035\024\020\017\004\036\f\022\017\036 \017\f\b\024\007\t\ \031)Tj /Span<>> BDC ( )Tj EMC (\r\030\024\f\035\t\b \f)Tj /Span<>> BDC ( )Tj EMC (\200\003\025\273 )Tj 0.148 Tw T* ([54] \r\t\016\r\035\036\027\024 \r\f\036\020\024 7)Tj /Span<>> BDC ( )Tj EMC (\(46,7%\) \017\f\f\035\036\007\024\r\026\027\017\005, \r)Tj /Span<>> BDC ( )Tj EMC (\022\024)Tj 0 Tw (-)Tj 0.129 Tw T* [(\021\024\030\t\b )0.5(\f\024\024\002\013\026\035\024\f\034 )0.6(\024)]TJ /Span<>> BDC ( )Tj EMC [(\027\036\032\036\035\026\021\036\035\034\027\t\b )0.5(\016\r\035\036\027\017\016\b )0.6(\(\203\247\). )]TJ 0.084 Tw T* (\200)Tj /Span<>> BDC ( )Tj EMC (\007\r\031\b \017\f\f\035\036\007\024\r\026\027\017\016\b \f\024\024\002\ \013\026\035\024\f\034 \024\002 \024\021\f\031\021\f\021\r\017\017 \203\247\ )Tj 0.113 Tw T* ([47,59]. \200)Tj /Span<>> BDC ( )Tj EMC (\007\030\031\020\017\b 5 \017\f\f\035\036\007\024\r\026\027\017\016\b \f\ \024\024\002\013\026\035\024\f\034 \024)Tj /Span<>> BDC ( )Tj EMC (15 )Tj 0.087 Tw T* (\027\036\f\036\030\034\036\027\t\b \203\247, \f\r\016\026\027\027\t\b \ \f)Tj /Span<>> BDC ( )Tj EMC (\205\203 [49,56,66], \026)Tj /Span<>> BDC ( )Tj EMC (\017\n\036\027)Tj 0 Tw (-)Tj 0.271 Tw T* [(\027\024: \f\022\036\035\036\021\027\024-\n\t\001\036\004\027\026\016 )0.5(\002\024\035\034 \()]TJ /T1_2 1 Tf 0 Tw (n)Tj /T1_0 1 Tf 0.271 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (5\) [66], \024\f\021\030\t\036 )Tj 0.081 Tw T* (\024\002\024\f\021\030\036\027\017\016 \()Tj /T1_2 1 Tf 0 Tw (n)Tj /T1_0 1 Tf 0.081 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (2\), \002\024\035\034 \r)Tj /Span<>> BDC ( )Tj EMC (\032\017\r\024\021\036 \r\024 \r\030\036\n\016 \017)Tj /Span<>> BDC ( )Tj EMC (\023\024\f\035\036 )Tj 0.039 Tw T* (\021\030\036\027\017\030\024\r\022\017 \()Tj /T1_2 1 Tf 0 Tw (n)Tj /T1_0 1 Tf 0.039 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (1\), \020\024\035\024\r\024\022\030\031\032\036\027\017\036 \()Tj /T1_2 1 Tf 0 Tw (n)Tj /T1_0 1 Tf 0.039 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (2\), \021\024\001\027\024\021\026 )Tj 0 Tw T* (\()Tj /T1_2 1 Tf (n)Tj /T1_0 1 Tf 0.006 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (1\) [49], \035\036\020\022\017\036 \020\024\035\024\r\027\t\036 \002\024\ \035\017 \017)Tj /Span<>> BDC ( )Tj EMC (\020\024\035\024\r\024\022\030\031\032\036\027\017\036 )Tj 0 Tw T* (\()Tj /T1_2 1 Tf (n)Tj /T1_0 1 Tf 0.093 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (2\), \030\r\024\021\026 \023\024\f\035\036 \205\203 \()Tj /T1_2 1 Tf 0 Tw (n)Tj /T1_0 1 Tf 0.093 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (1\) [56], \017)Tj /Span<>> BDC ( )Tj EMC (\030\026\007\030\026\032\036\027\017\036 )Tj -0.05 Tw T* (\022\024\032\017 \()Tj /T1_2 1 Tf 0 Tw (n)Tj /T1_0 1 Tf -0.05 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (1\) [52]. \230\024\035\034\022\024 \031)Tj /Span<>> BDC ( )Tj EMC (2 \(\017 53 \023\026\006\017\036\027\021\024\r\) \r\024\027\017\022 )Tj 0.253 Tw T* (\030\036\006\017\007\017\r \026\002\024\035\036\r\026\027\017\016 [63].\ \200)Tj /Span<>> BDC ( )Tj EMC (\024\007\027\024\n \017\f\f\035\036\007\024\r\026\027\017\036 )Tj 0.012 Tw T* ([66] \f\024\024\002\013\026\035\024\f\034 \024)Tj /Span<>> BDC ( )Tj EMC (\f\036\030\034\036\027\t\b \203\247: \024)Tj /Span<>> BDC ( )Tj EMC (2 \020\024\f\023\017\021\026\035\017\026\006\017)Tj 0 Tw (-)Tj 0.036 Tw T* (\016\b \017-\026 \024\002\024\f\021\030\036\027\017\016 \017)Tj /Span<>> BDC ( )Tj EMC (\024\002 \024\007\027\024\n \f\035\031\004\026\036 \022\024\035\024\030\036\ \022\021\026\035\034)Tj 0 Tw (-)Tj 0.062 Tw T* (\027\024\020\024 \030\026\022\026. \200\024 \r\f\036\b \007\030\031\020\017\ \b \017\f\f\035\036\007\024\r\026\027\017\016\b, \r\024\001\036\007\001\017\ \b )Tj 0 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\n\036\021\026\026\027\026\035\017, \027\036 \f\024\024\002\013\026\035\ \024\f\034 \024)Tj /Span<>> BDC ( )Tj EMC (\f\036\030\034\036\027\t\b \203\247 [54].)Tj 0.406 Tw T* (\217\016\007 \017\f\f\035\036\007\024\r\026\027\017\005 [62,67,68] \r\022\ \035\033\004\026\035 \031\004\026\f\021\027\017\022\024\r )Tj 0.068 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\026\022\021\017\r\027\t\n \200\003\025, \r\024 \r\f\036\b \220\021\017\b\ \017\f\f\035\036\007\024\r\026\027\017\016\b \027\036 \031\007\026)Tj 0 Tw (-)Tj 0.385 Tw T* (\035\024\f\034 \031\f\021\026\027\024\r\017\021\034 \023\024\035\024\032\ \017\021\036\035\034\027\031\033 \f\r\016\034 \n\036\032\007\031 \205\202\ )Tj -0.03 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\026\022\021\017\r\027\t\n \026\002\024\035\036\r\026\027\017\036\n. \200\ \n\036\f\021\036 \f)Tj /Span<>> BDC ( )Tj EMC (\220\021\017\n, \023\024\f\035\036 \027\026\004\026)Tj 0 Tw (-)Tj 0.01 Tw T* [(\035\026 \205\211 )0.5(\r\030\024\f\035\t\036 )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC [(\200\003\025 )0.5(\f\024\024\002\013\026\035\017 \024\002 )0.5(\031\035\031\004\001\036\027\017\017 )0.5(\f\024\f\021\024)]TJ 0 Tw (-)Tj -0.009 Tw T* (\016\027\017\016 \f\r\024\036\020\024 \235\017\017\004\036\f\022\024\020\ \024 \007\024\030\024\r\034\016, \026)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\032\036 \024)Tj /Span<>> BDC ( )Tj EMC (\035\031\004\001\036\n )Tj 0 Tw T* (\035\036\004\036\027\017\017 \f\017\n\023\021\024\n\024\r \200\003\025 [\ 9].)Tj 0.187 Tw T* (\216\024\021\016 \024\002\013\026\016 \023\024\035\034\026 \205\211 \017\ )Tj /Span<>> BDC ( )Tj EMC (\031\027\017\r\036\030\f\026\035\034\027\024 \002\036\024\023\026\f\027\ \t\005 )Tj 0.036 Tw T* [(\023\030\024\235\017\035\034 \002\024\035\034\001\017\027\f\021\r\026 )0.5(\030\036\032\017\n\024\r \031\023\030\026\032\027\036\027\017\005 )0.5(\024\004\036\r\017\007)]TJ 0 Tw (-)Tj 0.106 Tw T* (\027\t, \004\030\036\n\036\030\027\t\036 \205\203 \n\024\020\031\021 \002\ \t\021\034 \035\017\n\017\021\017\030\031\033\013\017\n \235\026\022)Tj 0 Tw (-)Tj 0.038 Tw T* (\021\024\030\024\n \017, \r\024\n\024\032\027\024, \024\023\026\f\027\t\ \n\017, \024\f\024\002\036\027\027\024 \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r )Tj 0.104 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\031\n\036\030\036\027\027\024\005 \017\035\017 \021\016\032\036\035\024\ \005 \026\022\021\017\r\027\024\f\021\034\033 \026\002\024\035\036\r\026\ \027\017\016 )Tj -0.002 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\023\024\f\035\036\007\f\021\r\017\016\n\017 \b\030\024\027\017\004\036\f\ \022\024\020\024 \026\002\024\035\036\r\026\027\017\016 \(\021\026\022\017\ \n\017, )Tj 0.017 Tw T* [(\022\026\022 )0.5(\026\027\036\n\017\016 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 5.653 0 Td [(\024\f\021\036\024\023\024\030\024\). )0.6(\205\211, )0.5(\r\036\030\024\016\021\027\024, )0.5(\035\031\004\001\036 )0.6(\r\f\036\020\024 )]TJ 0 Tw -5.653 -1.218 Td (\023\024\007\b\024\007\016\021 \007\035\016 \023\026\006\017\036\027\021\ \024\r \r)Tj /Span<>> BDC ( )Tj EMC (\f\021\026\007\017\017 \030\036\n\017\f\f\017\017 [16].)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\214)10(\211\036\033 \035\030\032\t\033)30(\b)42(\032)-21(\240\033\233)]TJ 57.136 0 Td (REVIEW)Tj -57.136 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 23, \023\0221)69(, 202)69(4)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 23, \023\0221)69(, 202)69(4)]TJ /T1_4 1 Tf 25 0 0 25 20.7277 56.0378 Tm (156)Tj ET endstream endobj 51 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 52 0 obj <>/ExtGState<>/Font<>/ProcSet[/PDF/Text]/Properties<>/Shading<>/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 53 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 54 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 55 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 673 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\210\220\222\220\017\016\006\n\220\016 \215\221\002\013\217\001\016\001\220\ \205 \n\013\n \232\225\225\016\n)-9.9(\026\220\r\001\013\205 )]TJ 0 -1 TD [(\013\201\230\212\r\013\001\026\001\013\205 \026)11(\016\002\013\221\220\205 \221\002\220\022\002\016\024\220\006\006\220\220\ \r\025\006\221\013\007\220\026)11(\016\007\216\001\020\207 )]TJ T* [(\222\013\f\025\007\016\r\013\001\220\203 \n\220\016\017\001\220\n\013 \(\ \025\f\222\025\002 \007\220\026)11(\016\002\013\026)-19.9(\215\002\020\))]TJ 43.88 2 Td [(Ph)31(y)10(sical e)21(x)10(er)31(cises as an ef)-30.9(fectiv)12(e adju)10(v)10(ant )]TJ 2.526 -1 Td [(th)11(er)21(apy of IBD in r)31.1(emission \(r)31(e)11(vie)11(w\))]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0.199 Tw 10 0 0 10 42.5197 724.8299 Tm (\024\027\017 \n\024\020\031\021 \r\t\023\024\035\027\016\021\034 [39]. \217\ \036\031\035\034\021\026\021\t \023\024\022\026\t\r\026\033\021, )Tj 0.294 Tw 0 -1.218 TD (\004\021\024 \026\220\030\024\002\027\t\036 \031\023\030\026\032\027\036\ \027\017\016 \f\023\024\f\024\002\f\021\r\031\033\021 \031\n\036\027\034\ \001\036)Tj 0 Tw (-)Tj 0.121 Tw T* (\027\017\033 \r\024\f\023\026\035\036\027\017\016 \r)Tj /Span<>> BDC ( )Tj EMC (\022\017\001\036\004\027\017\022\036 \017)Tj /Span<>> BDC ( )Tj EMC (\023\024\r\t\001\026\033\021 \022\026\004\036\f\021\r\024 )Tj 0 Tw T* (\032\017\027\017.)Tj 0.306 Tw T* (\212\030\031\020\024\005 \021\017\023 \205\211, \022\024\021\024\030\t\005\ \r\t\t\r\026\036\021 \017\f\f\035\036\007\024\r\026\021\036\035\034)Tj 0 Tw (-)Tj 0.053 Tw T* (\f\022\017\005 \017\027\021\036\030\036\f \r)Tj /Span<>> BDC ( )Tj EMC (\024\021\027\024\001\036\027\017\017 \036\020\024 \r\035\017\016\027\017\ \016 \027\026)Tj /Span<>> BDC ( )Tj EMC (\f\017\n\023\021\024\n\t )Tj -0.037 Tw 0 -1.218 TD (\207\025)Tj /Span<>> BDC ( )Tj EMC (\227 \220\021\024 \031\023\030\026\032\027\036\027\017\016 \f)Tj /Span<>> BDC ( )Tj EMC (\024\021\016\020\024\013\036\027\017\016\n\017, \021\026\022 \022\026\022\ \027\036\035\034\016 )Tj 0.059 Tw 0 -1.218 TD (\031\023\031\f\022\026\021\034 \017)Tj /Span<>> BDC ( )Tj EMC (\r\017\007\031 \007\017\f\235\031\027\022\006\017\033 \f\022\036\035\036\ \021\027\t\b \n\t\001\006 \031)Tj /Span<>> BDC ( )Tj EMC (\023\026)Tj 0 Tw (-)Tj 0.121 Tw T* [(\006\017\036\027\021\024\r )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC 4.502 0 Td [(\200\003\025, )0.5(\022\024\021\024\030\026\016 )0.6(\016\r\035\016\036\021\f\016 )0.5(\030\026\f\023\030\024\f\021\030\026\027\036\027\027\t\n )]TJ -0.041 Tw -4.502 -1.218 Td [(\016\r\035\036\027\017\036\n )0.6([40]. )0.5(\211)]TJ /Span<>> BDC ( )Tj EMC 7.059 0 Td [(\023\026\006\017\036\027\021\024\r )0.6(\f)]TJ /Span<>> BDC ( )Tj EMC 5.142 0 Td [(\207\025, )0.5(\022\024\021\024\030\t\036 )0.5(\027\026\b\024\007\017\035\017\f\034 )]TJ 0.276 Tw -12.201 -1.218 Td (\r)Tj /Span<>> BDC ( )Tj EMC 0.982 0 Td [(\030\036\n\017\f\f\017\017, )0.5(\021\030\036\027\017\030\024\r\022\017 )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC 10.948 0 Td [(\024\021\016\020\024\013\036\027\017\036\n )0.6(\(\024\f\027\024\r\027\026\016 )]TJ -0.027 Tw -11.931 -1.218 Td [(\235\026\026 )0.6(\021\030\036\027\017\030\024\r\024\004\027\024\005 )0.5(\023\030\024\020\030\026\n\n\t )0.6(\007\024\035\032\027\026 )0.5(\017\n\036\021\034 )0.6(\023\024\f\021\036)]TJ 0 Tw (-)Tj 0.342 Tw 0 -1.218 TD (\023\036\027\027\024\036 \031\r\036\035\017\004\036\027\017\036 \017\027\ \021\036\027\f\017\r\027\024\f\021\017 \(\017\027\021\036\027\f\017\r\027\ \024\f\021\034 )Tj 0.172 Tw 0 -1.218 TD [(60\22680%, \023\036\030\017\024\007\t )0.5(\024\021\007\t\b\026 )0.5(15\22630)]TJ /Span<>> BDC ( )Tj EMC [(\f\036\022\031\027\007 )0.5(\023\024\f\035\036 \022\026\032)]TJ 0 Tw (-)Tj 0.022 Tw 0 -1.218 TD [(\007\024\020\024 )0.5(\031\023\030\026\032\027\036\027\017\016, )0.6(2\2263)]TJ /Span<>> BDC ( )Tj EMC 9.417 0 Td [(\n\017\027\031\021\t )0.5(\n\036\032\007\031 )0.6(\031\023\030\026\032\027\036\027\017\016\n\017\) )]TJ 0.052 Tw -9.417 -1.218 Td (\031\035\031\004\001\017\035\017 \n\t\001\036\004\027\031\033 \f\017\035\ \031 \017)Tj /Span<>> BDC ( )Tj EMC (\022\026\004\036\f\021\r\024 \032\017\027\017. \210\007\027\026\022\024\ )Tj -0.038 Tw T* (\f\036\022\030\036\006\017\016 IL-6, \022\026\022 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\207\025, \021\026\022 \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\017 \021\030\036\027\017\030\024\r\022\036 \f)Tj /Span<>> BDC ( )Tj EMC (\024\021\016)Tj 0 Tw (-)Tj 0.191 Tw T* (\020\024\013\036\027\017\036\n, \031\004\026\f\021\r\031\036\021 \r)Tj /Span<>> BDC ( )Tj EMC (\030\026\035\017\004\027\t\b \235\017\017\024\035\024\020\017\004\036\f\ \022\017\b )Tj 0.042 Tw T* [(\n\036\b\026\027\017\n\026\b, \004\021\024 \021\030\036\002\031\036\021\ )0.5(\007\024\023\024\035\027\017\021\036\035\034\027\t\b \017\f\f\035\036\007\ \024\r\026)]TJ 0 Tw (-)Tj T* (\027\017\005 [41].)Tj -0.026 Tw T* (\215\024\f\035\036 8-\027\036\007\036\035\034\027\024\020\024 \021\030\036\ \027\017\030\024\r\024\004\027\024\020\024 \023\036\030\017\024\007\026 \ \023\024)Tj /Span<>> BDC ( )Tj EMC (\023\030\024)Tj 0 Tw (-)Tj 0.292 Tw T* [(\020\030\026\n\n\036 \253\023\030\024\020\030\036\f\f\017\r\027\026\016 \ )0.5(\021\030\036\027\017\030\024\r\022\026 \f)]TJ /Span<>> BDC ( )Tj EMC (\024\021\016\020\024\013\036\027\017\016)Tj 0 Tw (-)Tj 0.029 Tw T* (\n\017\273 \007\035\016 \023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\200\003\025 \f)Tj /Span<>> BDC ( )Tj EMC (\031\f\021\026\027\024\r\035\036\027\027\024\005 \f\035\026\002\024\f\021\ \034\033 )Tj 0.361 Tw T* [(\004\036\021\t\030\036\b\020\035\026\r\024\005 )0.6(\n\t\001\006\t )0.5(\027\026\002\035\033\007\026\035\017\f\034 )0.5(\027\026\004\017\021\036\035\034\027\t\036 )]TJ 0.177 Tw T* (\031\035\031\004\001\036\027\017\016 \023\026\030\026\n\036\021\030\024\r\ \f\017\035\t \004\036\021\t\030\036\b\020\035\026\r\024\005 \n\t\001\006\ \t )Tj 0.112 Tw T* (\002\036\007\030\026 \(\r \017\f\f\035\036\007\024\r\026\027\017\017 \023\ \030\024\r\024\007\017\035\026\f\034 \017\024\035\017\030\024\r\026\027\ \027\026\016 )Tj 0.157 Tw T* (\023\030\024\020\030\036\f\f\017\r\027\026\016 \021\030\036\027\017\030\024\ \r\022\026 \f)Tj /Span<>> BDC ( )Tj EMC (\031\004\026\f\021\017\036\n \021\024\035\034\022\024 \004\036\021\t)Tj 0 Tw (-)Tj 0.275 Tw T* (\030\036\b\020\035\026\r\024\005 \n\t\001\006\t\) \017)Tj /Span<>> BDC ( )Tj EMC (\022\026\004\036\f\021\r\026 \032\017\027\017. \215\024\035\031\004\036\ \027\027\024\036 )Tj 0.208 Tw T* [(\031\r\036\035\017\004\036\027\017\036 )0.6(\f\017\035\t )0.5(\004\036\021\t\030\036\b\020\035\026\r\024\005 )0.6(\n\t\001\006\t )0.5(\002\024\035\036\036 )0.5(\004\036\n )]TJ 0.096 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC (40% \f\024\020\035\026\f\031\036\021\f\016 \f)Tj /Span<>> BDC ( )Tj EMC (\r\036\035\017\004\017\027\024\005, \023\024\035\031\004\036\027\027\024\ \005 \031)Tj /Span<>> BDC ( )Tj EMC (\007\024)Tj 0 Tw (-)Tj 0.008 Tw T* (\030\024\r\t\b \r\030\024\f\035\t\b \035\033\007\036\005, \r\036\007\031\ \013\017\b \n\026\035\024\023\024\007\r\017\032\027\t\005 \024\002)Tj 0 Tw (-)Tj -0.033 Tw T* (\030\026 \032\017\027\017, \017)Tj /Span<>> BDC ( )Tj EMC (\031 \023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\007\030\031\020\017\n\017 \b\030\024\027\017\004\036\f\022\017\n\017 \026\ )Tj 0 Tw (-)Tj -0.006 Tw T* (\002\024\035\036\r\026\027\017\016\n\017. \215\030\036\007\035\024\032\036\ \027\027\026\016 \023\030\024\020\030\026\n\n\026 \031\023\030\026\032\027\ \036\027\017\005 )Tj 0.145 Tw T* (\024\022\026\026\035\026\f\034 \002\036\024\023\026\f\027\024\005, \021\ \026\022 \022\026\022 \027\036 \002\t\035\024 \026\030\036\020\017\f\021\ \030\017)Tj 0 Tw (-)Tj 0.008 Tw T* (\030\024\r\026\027\024 \027\017\022\026\022\017\b \n\t\001\036\004\027\t\ \b \023\024\r\030\036\032\007\036\027\017\005 \017)Tj /Span<>> BDC ( )Tj EMC (\023\024\035\036\027\024\005, )Tj 0.086 Tw T* (\004\021\024 \023\030\017\r\024\007\017\021 \022)Tj /Span<>> BDC ( )Tj EMC (\024\002\255\036\022\021\017\r\027\024\n\031 \031\035\031\004\001\036\027\ \017\033 \n\t\001\036\004\027\024\005 )Tj 0.141 Tw T* [(\f\017\035\t. )0.5(\025\030\024\n\036 \021\024\020\024, \031\023\030\026\032\027\036\027\017\ \016 )0.5(\027\036 )0.5(\031\f\031\020\031\002\035\016\035\017 )0.5(\f\017\n\023)]TJ 0 Tw (-)Tj T* (\021\024\n\t \200\003\025 \031)Tj /Span<>> BDC ( )Tj EMC (\031\004\026\f\021\027\017\022\024\r [42].)Tj 0.527 Tw T* [(\221\030\026\r\027\036\027\017\036 \026\220\030\024\002\027\t\b \031\023\ \030\026\032\027\036\027\017\005 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC (\031\023\030\026\032\027\036\027\017\005 )Tj 0.197 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\024\021\016\020\024\013\036\027\017\016\n\017 \023\030\024\007\036\n\024\ \027\f\021\030\017\030\024\r\026\035\024 \027\026\004\017\021\036\035\034\ \027\024\036 )Tj 0.289 Tw T* [(\f\027\017\032\036\027\017\036 )0.6(TNF-\263, )0.5(IL-6 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 11.005 0 Td [(IL-10 )0.5(\023\030\017)]TJ /Span<>> BDC ( )Tj EMC 4.734 0 Td [(\026\220\030\024\002\027\t\b )0.6(\r\n\036)]TJ 0 Tw (-)Tj 0.348 Tw -15.739 -1.218 Td (\001\026\021\036\035\034\f\021\r\026\b \017)Tj /Span<>> BDC ( )Tj EMC (\024\021\f\031\021\f\021\r\017\036 \f\031\013\036\f\021\r\036\027\027\t\b\ \030\026\035\017\004\017\005 )Tj 0.255 Tw T* (\023\030\017)Tj /Span<>> BDC ( )Tj EMC (\r\n\036\001\026\021\036\035\034\f\021\r\036 \f)Tj /Span<>> BDC ( )Tj EMC (\024\021\016\020\024\013\036\027\017\016\n\017, \027\026)Tj /Span<>> BDC ( )Tj EMC (\024\f\027\024\r\026\027\017\017 )Tj -0.023 Tw T* (\004\036\020\024 \026\r\021\024\030\t \007\036\035\026\033\021 \r\t\r\024\ \007, \004\021\024 \026\220\030\024\002\027\t\036 \031\023\030\026\032\027\ \036\027\017\016 )Tj 0.008 Tw T* (\002\024\035\036\036 \023\024\007\b\024\007\016\021 \007\035\016 \n\024\007\ \031\035\016\006\017\017 \n\026\030\022\036\030\024\r \r\024\f\023\026\035\ \036\027\017\016 )Tj 0 Tw T* (\031)Tj /Span<>> BDC ( )Tj EMC (\023\024\032\017\035\t\b \035\033\007\036\005 [43].)Tj 0.343 Tw T* (\200 \007\r\031\b \002\024\035\034\001\017\b \023\030\024\f\023\036\022\021\ \017\r\027\t\b \022\024\020\024\030\021\026\b \032\036\027\013\017\027 )Tj 0.063 Tw T* [(\221\234\202 )0.5(\(\r )0.5(\021\036\004\036\027\017\036 )0.6(3 )0.5(421 )0.5(972 )0.5(\004\036\035\024\r\036\022\024-\035\036\021 )0.6(\027\026\002\035\033\007\036\027\017\016 )]TJ -0.014 Tw T* (\026\030\036\020\017\f\021\030\017\030\024\r\026\035\017 284 \f\035\031\ \004\026\016 \207\025 \017)Tj /Span<>> BDC ( )Tj EMC (363 \f\035\031\004\026\016 \247\025\) \205\202 )Tj 0.084 Tw T* [(\002\t\035\026 )0.5(\024\002\030\026\021\027\024 )0.6(\023\030\024\023\024\030\006\017\024\027\026\035\034\027\026 )0.6(\030\017\f\022\031 )0.5(\207\025, )0.5(\027\024 )0.5(\027\036 )0.5(\247\025. )]TJ 0.08 Tw T* (\202\022\021\017\r\027\t\036 \032\036\027\013\017\027\t \f)Tj /Span<>> BDC ( )Tj EMC (\205\202 \027\036 \n\036\027\036\036 27 \004\026\f\024\r \n\036\021\026\002\ \024)Tj 0 Tw (-)Tj -0.002 Tw T* (\035\017\004\036\f\022\024\020\024 \220\022\r\017\r\026\035\036\027\021\026\ \(\204\224\230\) \r)Tj /Span<>> BDC ( )Tj EMC (\027\036\007\036\035\033 \017\n\036\035\017 \f\027\017\032\036)Tj 0 Tw (-)Tj 0.087 Tw T* (\027\017\036 \030\017\f\022\026 \030\026\r\017\021\017\016 \207\025 \027\ \026)Tj /Span<>> BDC ( )Tj EMC (44% \(\022\024\220\235\235\017\006\017\036\027\021 \030\017\f\022\026 )Tj 0.155 Tw T* (0,56, 95% \007\024\r\036\030\017\021\036\035\034\027\t\005 \017\027\021\036\ \030\r\026\035 \024\021 0,37 \007\024)Tj /Span<>> BDC ( )Tj EMC (0,84\) )Tj 0.04 Tw 23.244 64.543 Td (\023\024)Tj /Span<>> BDC ( )Tj EMC (\f\030\026\r\027\036\027\017\033 \f)Tj /Span<>> BDC ( )Tj EMC (\032\036\027\013\017\027\026\n\017, \r\036\007\031\013\017\n\017 \n\026\035\ \024\023\024\007\r\017\032)Tj 0 Tw (-)Tj T* (\027\t\005 \024\002\030\026 \032\017\027\017 [44].)Tj /T1_2 1 Tf 0.198 Tw 0 -2.436 TD (\026\f\t\235\b\t\r \203\032 \b\004)Tj /Span<>> BDC ( )Tj EMC (\214\t\b\r\006\004\f\001\b\210\211 \212\f\002\003\b\002\217\003\001 \220\ \002\217\003\b\002\005 )Tj 0 Tw 0 -1.218 TD (\003\220\004\b\t)Tj /T1_1 1 Tf -0.056 Tw T* [(\203\026\030\031\001\036\027\017\016 )0.6(\024\023\024\030\027\024-\007\r\017\020\026\021\036\035\034\027\024\020\024\ )0.6(\026\023\023\026\030\026\021\026 )0.5(\016\r\035\016\033\021\f\016 )]TJ -0.075 Tw 0 -1.218 TD (\024\007\027\017\n\017 \017)Tj /Span<>> BDC ( )Tj EMC (\027\026\017\002\024\035\036\036 \004\026\f\021\t\b \r\027\036\022\017\001\ \036\004\027\t\b \023\030\024\016\r\035\036\027\017\005 )Tj 0.075 Tw 0 -1.218 TD (\017)Tj /Span<>> BDC ( )Tj EMC (\024\f\035\024\032\027\036\027\017\005 \200\003\025, \024\f\024\002\036\027\ \027\024 \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\207\025 [45]. )Tj 0.13 Tw T* (\211\004\017\021\t\r\026\016 \030\017\f\022 \030\026\r\017\021\017\016 \ \024\f\021\036\024\023\024\030\024\026 \023\024)Tj /Span<>> BDC ( )Tj EMC (\f\030\026\r\027\036\027\017\033 )Tj 0.243 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\027\026\f\036\035\036\027\017\036\n, \r)Tj /Span<>> BDC ( )Tj EMC (\006\036\035\024\n, \027\036\024\002\b\024\007\017\n\024 \030\026\f\f\n\026\ \021\030\017\r\026\021\034 )Tj 0.072 Tw T* [(\023\030\024\235\017\035\026\022\021\017\004\036\f\022\017\036 )0.6(\220\235\235\036\022\021\t )0.6(\205\202, )0.5(\r\022\035\033\004\026\033\013\017\036 )0.6(\r)]TJ /Span<>> BDC ( )Tj EMC 20.228 0 Td (\f\036\002\016 )Tj -0.015 Tw -20.228 -1.218 Td (\031\007\026\030\027\t\036 \205\211 \f)Tj /Span<>> BDC ( )Tj EMC (\027\026\020\030\031\022\024\005 [46]. \205\211 \f)Tj /Span<>> BDC ( )Tj EMC (\n\026\035\024\005 \031\007\026\030\027\024\005 \027\026)Tj 0 Tw (-)Tj 0.167 Tw 0 -1.218 TD (\020\030\031\022\024\005 \023\024\r\t\001\026\033\021 \n\017\027\036\030\ \026\035\034\027\031\033 \023\035\024\021\027\024\f\021\034 \022\024\f\021\ \027\024\005 )Tj -0.032 Tw 0 -1.218 TD [(\021\022\026\027\017 \(\r \024\002\035\026\f\021\017 \021\026\024\002\036\ \007\030\036\027\027\024\020\024 )0.5(\f\031\f\021\026\r\026 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC (\023\024\r\024\027\024\004)Tj 0 Tw (-)Tj -0.04 Tw 0 -1.218 TD (\027\017\022\026, \004\036\030\036 12 \n\036\f\016\006\036\r\) \023\030\ \017)Tj /Span<>> BDC ( )Tj EMC (\207\025 [47]. \210\007\027\026\022\024 \n\036\021\026\026\027\026)Tj 0 Tw (-)Tj 0.038 Tw T* (\035\017 2014 \020\024\007\026 \024\021\n\036\021\017\035 \027\036\007\024\ \f\021\026\021\024\004\027\024\f\021\034 \007\026\027\027\t\b, \023\024\007\ )Tj 0 Tw (-)Tj 0.183 Tw T* (\021\r\036\030\032\007\026\033\013\017\b \220\235\235\036\022\021\017\r\027\ \024\f\021\034 \205\211 \f)Tj /Span<>> BDC ( )Tj EMC (\027\017\022\024\005 \031\007\026\030\027\024\005 )Tj 0.115 Tw T* (\027\026\020\030\031\022\024\005 \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\027\017\022\024\005 \n\017\027\036\030\026\035\034\027\024\005 \023\035\ \024\021)Tj 0 Tw (-)Tj T* (\027\024\f\021\034\033 \022\024\f\021\027\024\005 \021\022\026\027\017 \023\ \030\017)Tj /Span<>> BDC ( )Tj EMC (\200\003\025 [48].)Tj 0.122 Tw T* (\200\003\025 \024\022\026\t\r\026\036\021 \027\036\002\024\035\034\001\024\ \036 \r\035\017\016\027\017\036 \027\026)Tj /Span<>> BDC ( )Tj EMC (\n\017\027\036\030\026\035\034\027\031\033 )Tj 0.299 Tw T* [(\023\035\024\021\027\024\f\021\034 )0.5(\022\024\f\021\017, \023\030\017)]TJ /Span<>> BDC ( )Tj EMC 9.721 0 Td [(\220\021\024\n \207\025 \023\030\036\007\f\021\026\r\035\016\036\021 )0.5(\002\024\035\034)]TJ 0 Tw (-)Tj 0.072 Tw -9.721 -1.218 Td [(\001\017\005 )0.6(\030\017\f\022, )0.5(\004\036\n )0.6(\247\025 )0.6([46]. )0.6(\200\n\036\f\021\036 )0.6(\f)]TJ /Span<>> BDC ( )Tj EMC 13.92 0 Td [(\220\021\017\n, )0.6(\023\024\f\035\036 )0.6(6 )0.6(\n\036\f\016)]TJ 0 Tw (-)Tj 0.229 Tw -13.92 -1.218 Td (\006\036\r \022\024\n\002\017\027\017\030\024\r\026\027\027\t\b \021\030\ \036\027\017\030\024\r\024\022 \f)Tj /Span<>> BDC ( )Tj EMC (\024\021\016\020\024\013\036\027\017\016\n\017 )Tj -0.017 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC 0.733 0 Td [(\021\030\036\027\017\030\024\r\024\022 )0.6(\027\026)]TJ /Span<>> BDC ( )Tj EMC 6.22 0 Td [(\n\t\001\036\004\027\031\033 )0.6(\235\031\027\022\006\017\033 )0.7(\031)]TJ /Span<>> BDC ( )Tj EMC 9.3 0 Td [(\r\030\024\f\035\t\b )0.6(\f)]TJ /Span<>> BDC ( )Tj EMC 4.743 0 Td (\207\025 )Tj 0.576 Tw -20.996 -1.218 Td (\r\t\016\r\035\036\027\024 \027\026\004\017\021\036\035\034\027\t\036 \031\ \035\031\004\001\036\027\017\016 \n\017\027\036\030\026\035\034\027\024\005\ )Tj 0.373 Tw T* (\023\035\024\021\027\024\f\021\017 \022\024\f\021\036\005, \023\024)Tj /Span<>> BDC ( )Tj EMC (\007\026\027\027\t\n \007\r\031\b\220\027\036\030\020\036\021\017\004\036\ \f\022\024\005 )Tj 0.201 Tw T* [(\030\036\027\021\020\036\027\024\r\f\022\024\005 \026\002\f\024\030\002\006\ \017\024\n\036\021\030\017\017, )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC [(\023\024\016\f\027\017\004\027\024\n )0.5(\024\021)]TJ 0 Tw (-)Tj 0.607 Tw T* (\007\036\035\036 \023\024\r\024\027\024\004\027\017\022\026 \(\f\022\024\ \030\030\036\022\021\017\030\024\r\026\027\027\026\016 \f\030\036\007\027\ \016\016 )Tj 0.025 Tw T* (\030\026\027\017\006\026 0,036 \020/\f\n)Tj 0 Tw 5.83 0 0 5.83 354.0972 387.1758 Tm (2)Tj 0.025 Tw 10 0 0 10 357.0121 383.8458 Tm (; 95% \212\222 0,024\2260,048; )Tj /T1_3 1 Tf 0 Tw (p)Tj /T1_1 1 Tf 0.025 Tw /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (0,001\). )Tj 0.092 Tw -8.205 -1.218 Td (\202\r\021\024\030\t \007\036\035\026\033\021 \r\t\r\024\007\t, \004\021\ \024 \007\026\027\027\026\016 \020\030\031\023\023\026 \205\211 \023\030\ \036\007)Tj 0 Tw (-)Tj 0.174 Tw T* (\f\021\026\r\035\016\036\021\f\016 \023\024\007\b\024\007\016\013\036\005\ \007\035\016 \f\027\017\032\036\027\017\016 \030\017\f\022\026 \024\f\021\ \036\024)Tj 0 Tw (-)Tj 0.079 Tw T* [(\023\024\030\024\021\017\004\036\f\022\017\b )0.6(\023\036\030\036\035\024\n\024\r )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 11.607 0 Td [(\017\027\r\026\035\017\007\027\024\f\021\017 )0.6(\r)]TJ /Span<>> BDC ( )Tj EMC 6.897 0 Td (\002\031\007\031\013\036\n )Tj 0 Tw -18.504 -1.218 Td ([49].)Tj 0.004 Tc 0.026 Tw T* (\211 \007\036\021\036\005 \017)Tj /Span<>> BDC ( )Tj EMC (\023\024\007\030\024\f\021\022\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\200\003\025 \r)Tj /Span<>> BDC ( )Tj EMC (\f\021\026\007\017\017 \030\036\n\017\f\f\017\017 6-\n\036)Tj 0 Tc 0 Tw (-)Tj 0.004 Tc 0.261 Tw T* [(\f\016\004\027\026\016 \023\030\024\020\030\026\n\n\026 \f\021\030\031\022\ \021\031\030\017\030\024\r\026\027\027\t\b \031\023\030\026\032\027\036\027\ \017\005)4( )]TJ 0.367 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\007\024\n\026\001\027\017\b \031\f\035\024\r\017\016\b \023\030\017\r\024\ \007\017\021 \022)Tj /Span<>> BDC ( )Tj EMC [(\027\026\004\017\021\036\035\034\027\024\n\031)4( )]TJ 0.32 Tw T* (\031\035\031\004\001\036\027\017\033 \n\017\027\036\030\026\035\034\027\024\ \005 \023\035\024\021\027\024\f\021\017 \022\024\f\021\036\005 \017)Tj /Span<>> BDC ( )Tj EMC (\n\t)Tj 0 Tc 0 Tw (-)Tj 0.004 Tc -0.016 Tw T* [(\001\036\004\027\024\005 \n\026\f\f\t \021\036\035\026. \215\024\220\021\ \024\n\031, \007\036\035\026\033\021 \r\t\r\024\007\t \026\r\021\024\030\ \t,)4( )]TJ 0.299 Tw T* [(\035\036\004\036\002\027\031\033 \235\017\022\031\035\034\021\031\030\031\ \f\035\036\007\031\036\021 \030\026\f\f\n\026\021\030\017\r\026\021\034\ \022\026\022)3.9( )]TJ 0.179 Tw T* [(\023\024\021\036\027\006\017\026\035\034\027\024 \f\n\036\032\027\031\033\ \f\024 \f\021\026\027\007\026\030\021\027\t\n\017 \n\036\021\024\007\026\ \n\017)4( )]TJ 0.173 Tw T* (\035\036\004\036\027\017\016 [50]. \203\036\f\n\024\021\030\016 \027\026\ )Tj /Span<>> BDC ( )Tj EMC [(\022\024\027\f\036\027\f\031\f \213\r\030\024\023\036\005\f\022\024\005)4( )]TJ 0.202 Tw T* (\024\030\020\026\027\017\026\006\017\017 \023\024)Tj /Span<>> BDC ( )Tj EMC (\002\024\030\034\002\036 \f)Tj /Span<>> BDC ( )Tj EMC (\207\025 \017)Tj /Span<>> BDC ( )Tj EMC (\247\025 [51] \r)Tj /Span<>> BDC ( )Tj EMC (\024\021\027\024\001\036)Tj 0 Tc 0 Tw (-)Tj 0.004 Tc 0.192 Tw T* [(\027\017\017 \021\024\020\024, \004\021\024 \007\035\016 \023\030\036\007\ \024\021\r\030\026\013\036\027\017\016 \023\024\021\036\030\017 \022\024\ \f\021\027\024\005)4( )]TJ 0.105 Tw T* (\n\026\f\f\t \f\035\036\007\031\036\021 \035\017 \r\t\023\024\035\027\016\ \021\034 \205\211 \f)Tj /Span<>> BDC ( )Tj EMC [(\024\021\016\020\024\013\036\027\017\036\n \017\035\017)4( )]TJ 0.577 Tw T* (\205\211 \f)Tj /Span<>> BDC ( )Tj EMC [(\f\024\023\030\024\021\017\r\035\036\027\017\036\n, \022\024\027\022\030\ \036\021\027\t\b \022\035\017\027\017\004\036\f\022\017\b)4.1( )]TJ 0.516 Tw T* (\030\036\022\024\n\036\027\007\026\006\017\005 \024\021\027\024\f\017\021\ \036\035\034\027\024 \021\017\023\026 \205\211, \017\027\021\036\027\f\017\ \r)Tj 0 Tc 0 Tw (-)Tj 0.004 Tc 0.224 Tw T* [(\027\024\f\021\017, )0.5(\023\030\024\007\024\035\032\017\021\036\035\034\027\024\f\021\017 )0.5(\017\035\017 )0.5(\004\026\f\021\024\021\t, )0.5(\004\021\024\002\t )0.5(\r\t)]TJ 0 Tc 0 Tw (-)Tj 0.004 Tc 0.053 Tw T* (\r\026\021\034 \002\035\026\020\024\023\030\017\016\021\027\t\036 \017\ \n\036\027\036\027\017\016 \r)Tj /Span<>> BDC ( )Tj EMC [(\022\024\f\021\027\024\005 \021\022\026\027\017, \027\036)4( )]TJ -0.004 Tw T* (\f\031\013\036\f\021\r\031\036\021.)Tj /T1_2 1 Tf 0 Tc 0.236 Tw 0 -2.436 TD (\026\f\t\235\b\t\r \203\223 \b\004)Tj /Span<>> BDC ( )Tj EMC (\214\013\230\r\201\b\210\211 \004\220\003\t\b\002\217\003\001 \t)Tj /Span<>> BDC ( )Tj EMC (\240\006\210\n\t\r )Tj 0.023 Tw 0 -1.218 TD (\217\t\214\212\003\002\214\013 \026\033\021)Tj /T1_1 1 Tf 0.734 Tw T* (\203\036\f\n\024\021\030\016 \027\026)Tj /Span<>> BDC ( )Tj EMC (\027\026\004\017\021\036\035\034\027\024\036 \027\026\030\031\001\036\027\ \017\036 \n\t\001\036\004)Tj 0 Tw (-)Tj 0.138 Tw T* [(\027\024\005 )0.5(\235\031\027\022\006\017\017 )0.6(\023\030\017)]TJ /Span<>> BDC ( )Tj EMC 7.788 0 Td [(\200\003\025 )0.5([1] )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 4.431 0 Td [(\036\201 )0.5(\f\r\016\034 )0.6(\f\024 \f\027\017\032\036\027\017\036\n )]TJ 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 0 Tw 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\214)10(\211\036\033 \035\030\032\t\033)30(\b)42(\032)-21(\240\033\233)]TJ 57.136 0 Td (REVIEW)Tj /T1_4 1 Tf 25 0 0 25 505.3897 56.0378 Tm (155)Tj ET endstream endobj 672 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.53 Tw 10 0 0 10 70.8661 724.8299 Tm (\f\017\020\027\026\035\026, \004\021\024\002\t \017\027\020\017\002\017\030\ \024\r\026\021\034 \023\030\024\r\024\f\023\026\035\017\021\036\035\034\027\ \t\036 )Tj -0.031 Tw 0 -1.218 TD (TNF-\263 \017)Tj /Span<>> BDC ( )Tj EMC (IL-1\256 [21], \r)Tj /Span<>> BDC ( )Tj EMC (\021\024 \r\030\036\n\016 \022\026\022 IL-6 \007\024\023\024\035\027\017\ \021\036\035\034\027\024 )Tj T* (\024\022\026\t\r\026\036\021 \017\027\020\017\002\017\030\031\033\013\036\ \036 \007\036\005\f\021\r\017\036 \027\026)Tj /Span<>> BDC ( )Tj EMC (\035\017\023\024\023\024\035\017\f\026\b\026)Tj 0 Tw (-)Tj 0.024 Tw T* (\030\017\007-\017\027\007\031\006\017\030\024\r\026\027\027\031\033 \023\ \030\024\007\031\022\006\017\033 TNF-\263 [14], \026)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\032\036 )Tj 0.057 Tw T* [(\f\021\017\n\031\035\017\030\031\016 )0.5(\r\t\f\r\024\002\024\032\007\036\027\017\036 \030\036\006\036\023\021\024\ \030\024\r \235\026\022\021\024\030\026 )0.5(\027\036)]TJ 0 Tw (-)Tj 0.087 Tw T* (\022\030\024\026 \024\023\031\b\024\035\017, \022\024\021\024\030\t\005\ \007\036\005\f\021\r\031\036\021 \022\026\022 \036\f\021\036\f\021\r\036\ \027\027\t\005 )Tj 0 Tw 0 -1.218 TD (\017\027\020\017\002\017\021\024\030 TNF-\263 [22].)Tj 0.116 Tw 0 -1.218 TD (\200\n\036\f\021\036 \f)Tj /Span<>> BDC ( )Tj EMC (\220\021\017\n, \022\026\022 \002\t\035\024 \024\002\027\026\030\031\032\ \036\027\024 \023\024\f\035\036 \r\t\f\024\022\024)Tj 0 Tw (-)Tj 0.147 Tw T* (\017\027\021\036\027\f\017\r\027\t\b \017\027\021\036\030\r\026\035\034\027\ \t\b \205\211 \(5 \023\024\007\b\024\007\024\r \b 4-\n\017)Tj 0 Tw (-)Tj -0.021 Tw T* (\027\031\021\027\t\b \017\027\021\036\030\r\026\035\024\r\) \027\026\002\ \035\033\007\026\036\n\024\036 \023\024\r\t\001\036\027\017\036 \031\030\ \024\r\027\016 )Tj 0.27 Tw T* (IL-6 \027\026\004\017\021\036\035\034\027\024 \r\t\001\036, \004\036\n \ \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\031\n\036\030\036\027\027\024\n \031\030\024\r)Tj 0 Tw (-)Tj 0.236 Tw T* (\027\036 \205\211 \024\007\017\027\026\022\024\r\024\005 \023\030\024\007\ \024\035\032\017\021\036\035\034\027\024\f\021\017 \(35 \n\017\027\031\021\ \). )Tj -0.041 Tw 0 -1.218 TD [(\202\027\026\035\024\020\017\004\027\026\016 )0.6(\022\024\030\030\036\035\016\006\017\016 )0.5(\024\021\n\036\004\036\027\026 )0.6(\f\024 )0.5(\f\030\036\007\027\017\n )0.5(\023\024\021\030\036)]TJ 0 Tw (-)Tj 0.13 Tw 0 -1.218 TD (\002\035\036\027\017\036\n \022\017\f\035\024\030\024\007\026 \023\030\017\ )Tj /Span<>> BDC ( )Tj EMC (\205\202, \026)Tj /Span<>> BDC ( )Tj EMC (\017\n\036\027\027\024 \027\026\004\017\021\036\035\034\027\024\036 )Tj 0.088 Tw 0 -1.218 TD [(\031\r\036\035\017\004\036\027\017\036 )0.5(\()]TJ /T1_1 1 Tf 0 Tw (P)Tj /T1_0 1 Tf 0.088 Tw /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (0,01\) VO)Tj 0 Tw 5.83 0 0 5.83 176.7899 552.3378 Tm (2)Tj 0.088 Tw 10 0 0 10 179.7049 554.3378 Tm ( max \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\024\007\017\027\026\022\024\r\024\005 \023\030\024)Tj 0 Tw (-)Tj 0.191 Tw -10.884 -1.218 Td (\007\024\035\032\017\021\036\035\034\027\024\f\021\017 \(35 \n\017\027\031\ \021\) \017)Tj /Span<>> BDC ( )Tj EMC (\030\026\035\017\004\027\024\005 \017\027\021\036\027\f\017\r)Tj 0 Tw (-)Tj 0.135 Tw T* (\027\024\f\021\017, \004\036\030\036\007\031\033\013\017\b\f\016 \n\036\032\ \007\031 80% \017)Tj /Span<>> BDC ( )Tj EMC (50%. \210\007\027\026\022\024 \027\036 )Tj 0.229 Tw T* (\002\t\035\024 \017\n\036\027\036\027\017\005 \r)Tj /Span<>> BDC ( )Tj EMC (\024\021\r\036\021\026\b \023\030\024\021\017\r\024\r\024\f\023\026\035\017\ \021\036\035\034\027\t\b )Tj 0 Tw T* (IL-10 \017\035\017 IL-4R \r)Tj /Span<>> BDC ( )Tj EMC (\023\035\026\n\036 [23].)Tj 0.246 Tw T* [(\200 \032\017\r\024\021\027\t\b \n\024\007\036\035\016\b )0.5(\022\024\035\017\021\026 \205\211 )0.5(\f\027\017\032\026\033\021 \220\022\f\023\030\036\f)]TJ 0 Tw (-)Tj 0.089 Tw T* (\f\017\033 \023\030\024\r\024\f\023\026\035\017\021\036\035\034\027\t\b \ \006\017\021\024\022\017\027\024\r, \021\026\022\017\b \022\026\022 TNF-\ \263 )Tj 0.218 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (IL-1\256, \023\024\r\t\001\026\033\021 \220\022\f\023\030\036\f\f\017\033\ IL-6 \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\021\017\r\024\r\024\f)Tj 0 Tw (-)Tj 0.437 Tw T* (\023\026\035\017\021\036\035\034\027\024\020\024 \006\017\021\024\022\017\ \027\026 IL-10, \024\f\035\026\002\035\016\033\021 \002\026\030\034\036\030\ )Tj 0 Tw (-)Tj 0.152 Tw T* (\027\031\033 \007\017\f\235\031\027\022\006\017\033 \017)Tj /Span<>> BDC ( )Tj EMC (\024\002\035\036\020\004\026\033\021 \021\036\004\036\027\017\036 \022\024\ \035\017\021\026 [24]. )Tj 0.126 Tw T* (\211\023\030\026\032\027\036\027\017\016 \027\026)Tj /Span<>> BDC ( )Tj EMC (\002\036\020\024\r\024\005 \007\024\030\024\032\022\036 \(5 \007\027\036\ \005 \r)Tj /Span<>> BDC ( )Tj EMC (\027\036\007\036\035\033, )Tj 0.023 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\021\036\004\036\027\017\036 6 \027\036\007\036\035\034\) \031)Tj /Span<>> BDC ( )Tj EMC (\022\030\t\f \027\026)Tj /Span<>> BDC ( )Tj EMC (\235\024\027\036 \007\017\036\021\t \f)Tj /Span<>> BDC ( )Tj EMC (\r\t\f\024\022\017\n )Tj 0.033 Tw T* (\f\024\007\036\030\032\026\027\017\036\n \032\017\030\024\r \027\026\004\ \017\021\036\035\034\027\024 \031\f\022\024\030\016\035\017 \026\032\017\ \r\035\036)Tj 0 Tw (-)Tj 0.109 Tw T* (\027\017\036 \220\022\f\023\036\030\017\n\036\027\021\026\035\034\027\024\ \020\024 \022\024\035\017\021\026, \023\030\017\r\024\007\017\035\017 \022\ )Tj /Span<>> BDC ( )Tj EMC (\023\024\r\t)Tj 0 Tw (-)Tj -0.031 Tw T* (\001\036\027\017\033 \031\030\024\r\027\016 IL-6 \017)Tj /Span<>> BDC ( )Tj EMC (\017\030\017\017\027\026 \r)Tj /Span<>> BDC ( )Tj EMC (\023\035\026\n\036, \022)Tj /Span<>> BDC ( )Tj EMC (\023\024\007\026\r\035\036\027\017\033 )Tj 0.204 Tw T* (\220\022\f\023\030\036\f\f\017\017 IL-1\256, TNF-\263 \017)Tj /Span<>> BDC ( )Tj EMC (Hif-1\263 \017)Tj /Span<>> BDC ( )Tj EMC (\027\026\004\017\021\036\035\034\027\024\n\031 )Tj 0.301 Tw T* (\f\027\017\032\036\027\017\033 \031\030\024\r\027\036\005 IL-1\256, TNF-\ \263 \r)Tj /Span<>> BDC ( )Tj EMC [(\023\035\026\n\036, T)-48(WEAK )]TJ 0 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\031\030\024\r\027\016 \035\036\023\021\017\027\026 [25].)Tj 0.026 Tw T* (\230\026\022\032\036 \023\030\036\007\023\024\035\026\020\026\036\021\f\016\ , \004\021\024 \023\030\024\r\024\f\023\026\035\017\021\036\035\034\027\t\ \005 \006\017\021\024)Tj 0 Tw (-)Tj 0.04 Tw T* (\022\017\027 IL-17 \017\020\030\026\036\021 \r\026\032\027\031\033 \030\024\ \035\034 \r)Tj /Span<>> BDC ( )Tj EMC (\r\024\f\023\026\035\036\027\017\017 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\200\003\025 )Tj 0.483 Tw T* (\026)Tj /Span<>> BDC ( )Tj EMC (\f\004\036\021 \031\f\017\035\036\027\017\016 \023\030\024\r\024\f\023\026\ \035\017\021\036\035\034\027\t\b \006\017\021\024\022\017\027\024\r, )Tj 0.091 Tw T* (\021\026\022\017\b \022\026\022 TNF-\263, IL-1\256 \017)Tj /Span<>> BDC ( )Tj EMC (IL-6 [26]. \210\007\027\026\022\024 \017\f\021\024\004\027\017\022 )Tj 0.005 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\023\030\017\004\017\027\026 \030\036\026\022\006\017\017 IL-17 \023\024\ \f\035\036 \205\202 \031)Tj /Span<>> BDC ( )Tj EMC (\007\024\030\024\r\t\b \035\033\007\036\005 )Tj 0.231 Tw T* (\n\036\027\036\036 \017\031\004\036\027\t [27]. \217\016\007 \017\f\f\035\ \036\007\024\r\026\027\017\005, \r)Tj /Span<>> BDC ( )Tj EMC (\022\024\021\024\030\t\b )Tj -0.031 Tw T* (\030\026\f\f\n\026\021\030\017\r\026\035\026\f\034 \r\026\017\n\024\f\r\ \016\034 IL-17 \017)Tj /Span<>> BDC ( )Tj EMC (\205\202 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\200\003\025 \017\035\017 )Tj -0.01 Tw T* (\002\036 \200\003\025, \027\036 \r\t\016\r\017\035 \f\031\013\036\f\021\ \r\036\027\027\t\b \030\026\035\017\004\017\005 \r)Tj /Span<>> BDC ( )Tj EMC (\f\017\f\021\036\n)Tj 0 Tw (-)Tj 0.016 Tw T* [(\027\t\b )0.5(\022\024\027\006\036\027\021\030\026\006\017\016\b )0.5(IL-17 )0.6(\023\030\017)]TJ /Span<>> BDC ( )Tj EMC 12.501 0 Td [(\027\026\020\030\031\022\036 )0.6(\(\017\027\021\036\027\f\017\r\027\024\005 )]TJ -0.045 Tw -12.501 -1.218 Td (\205\203 \017\035\017 \017\027\021\036\030\r\026\035\034\027\t\b \031\023\ \030\026\032\027\036\027\017\016 \f\030\036\007\027\036\005 \017\027\021\ \036\027\f\017\r)Tj 0 Tw (-)Tj 0.132 Tw T* (\027\024\f\021\017\) [28, 29]. \215\030\024\r\036\007\201\027\027\t\005 \ \r)Tj /Span<>> BDC ( )Tj EMC (2022 \020\024\007\031 \n\036\021\026\026\027\026)Tj 0 Tw (-)Tj 0.054 Tw T* (\035\017 \023\030\036\007\023\024\035\026\020\026\036\021 \024\021\f\031\ \021\f\021\r\017\036 \r\035\017\016\027\017\016 \027\026)Tj /Span<>> BDC ( )Tj EMC (IL-17 \023\024\f\035\036 )Tj -0.022 Tw T* (\017\027\021\036\030\r\026\035\034\027\t\b \031\023\030\026\032\027\036\027\ \017\005 \f\030\036\007\027\036\005 \017)Tj /Span<>> BDC ( )Tj EMC (\r\t\f\024\022\024\005 \017\027\021\036\027)Tj 0 Tw (-)Tj T* (\f\017\r\027\024\f\021\017 [30].)Tj -0.023 Tw T* (\204\024\032\027\024 \024\002\024\002\013\017\021\034, \004\021\024 \024\ \f\027\024\r\027\t\036 \023\030\024\021\017\r\024\r\024\f\023\026\035\017\ \021\036\035\034)Tj 0 Tw (-)Tj -0.04 Tw T* [(\027\t\036 )0.5(\220\235\235\036\022\021\t )0.5(\205\211 )0.5(\f\r\016\026\027\t )0.6(\f)]TJ /Span<>> BDC ( )Tj EMC 11.221 0 Td [(\r\t\f\r\024\002\024\032\007\036\027\017\036\n )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC 8.524 0 Td (\n\t\001\006 )Tj -0.027 Tw -19.745 -1.218 Td (\n\017\024\022\017\027\024\r, \021\026\022\017\b \022\026\022 IL-6, IL-1\ 0 \017)Tj /Span<>> BDC ( )Tj EMC [(IL-1R)-9.9(a. \224\021\017 \n\017\024\022\017\027\t )]TJ 0.053 Tw T* [(\017\027\020\017\002\017\030\031\033\021 )0.6(\023\030\024\007\031\022\006\017\033 )0.5(TNF-\263, )0.5(\004\021\024 )0.6(\031\n\036\027\034\001\026\036\021 )0.5(\r\024\f\023\026)]TJ 0 Tw (-)Tj T* (\035\036\027\017\036 \022\017\001\036\004\027\017\022\026 [9].)Tj 0.275 Tw T* (\207\036\035\024\022 \024\f\021\030\024\005 \235\026\t)Tj /Span<>> BDC ( )Tj EMC (\227 \221-\030\036\026\022\021\017\r\027\t\005 \002\036\035\024\022 \(\221\ \217\207\), )Tj 0.527 Tw T* (\016\r\035\016\036\021\f\016 \b\024\030\024\001\024 \026\030\036\022\024\ \n\036\027\007\024\r\026\r\001\017\n \f\036\002\016 \n\026\030)Tj 0 Tw (-)Tj 0.499 Tw T* (\022\036\030\024\n \200\003\025 [31]. \221\027\017\032\036\027\017\036 \221\ \217\207 \r)Tj /Span<>> BDC ( )Tj EMC (\035\024\027\020\017\021\033\007\027\t\b )Tj 0.065 Tw 23.244 64.543 Td (\017\f\f\035\036\007\024\r\026\027\017\016\b \031\022\026\t\r\026\036\021\ \027\026)Tj /Span<>> BDC ( )Tj EMC (\021\024, \004\021\024 \030\036\020\031\035\016\030\027\t\036 \021\030\036\ )Tj 0 Tw (-)Tj 0.315 Tw 0 -1.218 TD (\027\017\030\024\r\022\017 \023\024\035\036\027\t \007\035\016 \031\n\036\ \027\034\001\036\027\017\016 \f\035\026\002\024\r\t\030\026\032\036\027)Tj 0 Tw (-)Tj 0.087 Tw 0 -1.218 TD (\027\024\020\024 \r\024\f\023\026\035\036\027\017\016 [11]. \222\n\036\033\ \021\f\016 \f\024\024\002\013\036\027\017\016 \024)Tj /Span<>> BDC ( )Tj EMC (\027\026\004\017)Tj 0 Tw (-)Tj 0.139 Tw 0 -1.218 TD (\021\036\035\034\027\024\n \f\027\017\032\036\027\017\017 \221\217\207 \022\ \026\022 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\027\036\002\024\035\034\001\017\b \017\020\030\024\r\t\b )Tj -0.04 Tw 0 -1.218 TD (\031\023\030\026\032\027\036\027\017\016\b, \021\026\022 \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\017 \r\036\035\024\f\017\023\036\007\027\024\n \023\030\024\021\ \024\022\024\035\036 \r\f\036)Tj 0 Tw (-)Tj 0.069 Tw 0 -1.218 TD (\020\024 \026)Tj /Span<>> BDC ( )Tj EMC (8 \027\036\007\036\035\034 [32]. \210\007\027\026\022\024 \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\200\003\025 \017-\026 )Tj 0.005 Tw 0 -1.218 TD (\024\020\030\026\027\017\004\036\027\017\016 \r)Tj /Span<>> BDC ( )Tj EMC (\007\017\026\005\027\036 \017\f\f\035\036\007\024\r\026\027\017\016 \027\ \036 \002\t\035\024 \007\024\f\021\024)Tj 0 Tw (-)Tj 0.027 Tw 0 -1.218 TD (\r\036\030\027\024\005 \030\026\027\017\006\t \r)Tj /Span<>> BDC ( )Tj EMC (\031\030\024\r\027\036 \221\217\207 \r)Tj /Span<>> BDC ( )Tj EMC (\021\036\004\036\027\017\036 \030\036\020\031\035\016\030\027\024\020\024\ )Tj 0.003 Tw T* (\023\036\030\017\024\007\026 \031\023\030\026\032\027\036\027\017\005 [3\ 0]. \221)Tj /Span<>> BDC ( )Tj EMC (\007\030\031\020\024\005 \f\021\024\030\024\027\t, \017\031\004\036\027\ )Tj 0 Tw (-)Tj 0.26 Tw T* (\027\t\b \r\n\036\001\026\021\036\035\034\f\021\r \f)Tj /Span<>> BDC ( )Tj EMC (\205\211 \n\024\032\036\021 \002\t\021\034 \027\036\007\024\f\021\026\021\ \024\004\027\024, )Tj 0.087 Tw T* (\004\021\024\002\t \r\t\r\026\021\034 \027\026\004\017\021\036\035\034\ \027\t\036 \024\002\013\017\036 \017\n\036\027\036\027\017\016 \n\026\030\ )Tj 0 Tw (-)Tj 0.162 Tw T* (\022\036\030\024\r \r\024\f\023\026\035\036\027\017\016 \031)Tj /Span<>> BDC ( )Tj EMC (\031\004\026\f\021\027\017\022\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\200\003\025 [30]. \210\007\027\026\022\024 )Tj 0.374 Tw T* (\r\024\f\023\026\035\017\021\036\035\034\027\t\005 \023\031\021\034 \016\ \r\035\016\036\021\f\016 \023\024\021\036\027\006\017\026\035\034\027\024\ \005 \021\036)Tj 0 Tw (-)Tj 0.185 Tw T* (\030\026\023\036\r\021\017\004\036\f\022\024\005 \n\017\001\036\027\034\033\ \007\035\016 \r\n\036\001\026\021\036\035\034\f\021\r \r)Tj /Span<>> BDC ( )Tj EMC (\024\002\030\026 )Tj 0.105 Tw T* [(\032\017\027\017, \027\026\023\030\026\r\035\036\027\027\t\b )0.5(\027\026)]TJ /Span<>> BDC ( )Tj EMC [(\f\027\017\032\036\027\017\036 )0.5(\026\002\024\035\036\r\026\036\n\024\f\021\017. )]TJ 0.022 Tw T* (\205\211 \b\024\030\024\001\024 \017\r\036\f\021\027\t \022\026\022 \r\026\ \032\027\026\016 \f\021\030\026\021\036\020\017\016 \f\027\017\032\036\027\ \017\016 )Tj 0 Tw T* (\030\017\f\022\026 \b\030\024\027\017\004\036\f\022\017\b \026\002\024\035\ \036\r\026\027\017\005 [33].)Tj 0.227 Tw T* (\204\024\032\027\024 \026\022\035\033\004\017\021\034, \004\021\024 \205\ \203 \017\027\007\031\006\017\030\031\036\021 \022\026\f\022\026\007 \023\ \030\024)Tj 0 Tw (-)Tj 0.358 Tw T* (\021\017\r\024\r\024\f\023\026\035\017\021\036\035\034\027\t\b \006\017\021\ \024\022\017\027\024\r, \f\023\036\006\017\235\017\004\036\f\022\017 \026\ )Tj 0 Tw (-)Tj 0.28 Tw T* (\023\031\f\022\026\036\n\t\005 \026)Tj /Span<>> BDC ( )Tj EMC (\f\004\036\021 \220\022\f\023\024\027\036\027\006\017\026\035\034\027\024\ \020\024 \031\r\036\035\017\004\036\027\017\016 )Tj 0.179 Tw T* (\n\t\001\036\004\027\024\020\024 IL-6, \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\017 \030\036\020\031\035\016\030\027\t\b \026\027\016\021\017\016\ \b \n\024\032\036\021 )Tj 0.055 Tw T* (\f\027\017\017\021\034 \002\026\026\035\034\027\t\036 \031\030\024\r\027\ \017 \006\017\030\022\031\035\017\030\031\033\013\017\b \r\024\f\023\026\ \035\017)Tj 0 Tw (-)Tj 0.022 Tw T* (\021\036\035\034\027\t\b \n\026\030\022\036\030\024\r \017)Tj /Span<>> BDC ( )Tj EMC (\023\024\021\036\027\006\017\026\035\034\027\024 \031\n\036\027\034\001\017\ \021\034 \b\030\024\027\017)Tj 0 Tw (-)Tj T* (\004\036\f\022\024\036 \r\024\f\023\026\035\036\027\017\036 \023\030\017\ )Tj /Span<>> BDC ( )Tj EMC (\200\003\025.)Tj /T1_2 1 Tf 0.023 Tw 0 -2.436 TD (\033\004\227\t\003\b\004\235 \006\002\f\001 \203\032 )Tj /Span<>> BDC ( )Tj EMC (\002\003\b\002\230\r\b\t\t \026\033\021)Tj /T1_0 1 Tf 0.002 Tc 0.11 Tw 0 -1.218 TD (\213\013\201 \r)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\001\035\024\n \r\036\022\036 \(1999 \020.\) \002\t\035\026 \ \r\023\036\030\r\t\036 \023\024\f\021\031)Tj 0 Tc 0 Tw (-)Tj 0.002 Tc 0.141 Tw T* (\035\017\030\024\r\026\027\026 \026\013\017\021\027\026\016 \030\024\035\ \034 \205\202 \r)Tj /Span<>> BDC ( )Tj EMC [(\024\021\027\024\001\036\027\017\017 \200\003\025. \230\026\022,)2( )]TJ 0.189 Tw T* (\002\t\035\024 \023\024\022\026\026\027\024, \004\021\024 \023\026\006\017\ \036\027\021\t \f)Tj /Span<>> BDC ( )Tj EMC (\207\025, \r\036\007\031\013\017\036 \n\026\035\024)Tj 0 Tc 0 Tw (-)Tj 0.002 Tc 0.218 Tw T* (\023\024\007\r\017\032\027\t\005 \024\002\030\026 \032\017\027\017, \n\ \024\020\031\021 \023\036\030\036\027\024\f\017\021\034 \027\017\022\024\ )Tj 0 Tc 0 Tw (-)Tj 0.002 Tc 0.346 Tw T* [(\017\027\021\036\027\f\017\r\027\t\036 \205\203 \f\030\036\007\027\036\005\ \023\030\024\007\024\035\032\017\021\036\035\034\027\024\f\021\017 \002\ \036)2( )]TJ 0.051 Tw T* (\024\002\024\f\021\030\036\027\017\016 \f\017\n\023\021\024\n\024\r [34]\ . \210\007\027\026\022\024 \r)Tj /Span<>> BDC ( )Tj EMC (\007\030\031\020\024\n \017\f\f\035\036)Tj 0 Tc 0 Tw (-)Tj 0.002 Tc 0.077 Tw T* [(\007\024\r\026\027\017\017 \027\036 \024\002\027\026\030\031\032\017\035\ \017 \027\017 \f\021\026\021\017\f\021\017\004\036\f\022\017 \027\026\004\ \017\n\t\b)2( )]TJ 0.097 Tw T* [(\017\n\036\027\036\027\017\005 \024\006\036\027\017\r\026\036\n\t\b \023\ \026\030\026\n\036\021\030\024\r \007\024\030\024\r\034\016 \240\025\230\ ,)2( )]TJ 0.07 Tw T* (\027\017 \027\026\004\017\021\036\035\034\027\t\b \017\n\036\027\036\027\ \017\005 \r)Tj /Span<>> BDC ( )Tj EMC (\026\022\021\017\r\027\024\f\021\017 \026\002\024\035\036\r\026)Tj 0 Tc 0 Tw (-)Tj 0.002 Tc -0.008 Tw T* (\027\017\016 \023\024\f\035\036 1 \004\026\f\026 \031\023\030\026\032\027\ \036\027\017\005 \027\026)Tj /Span<>> BDC ( )Tj EMC [(\r\036\035\024\220\030\020\024\n\036\021\030\036 [35].)2( )]TJ 0.184 Tw T* (\200\n\036\f\021\036 \f)Tj /Span<>> BDC ( )Tj EMC (\220\021\017\n, \205\211 \027\017\022\024\005 \017\027\021\036\027\f\017\ \r\027\024\f\021\017 \027\036 \031\f\031\020\031)Tj 0 Tc 0 Tw (-)Tj 0.002 Tc 0.172 Tw T* (\002\035\016\033\021 \032\036\035\031\007\024\004\027\024-\022\017\001\036\ \004\027\t\036 \f\017\n\023\021\024\n\t \017)Tj /Span<>> BDC ( )Tj EMC (\027\036 \023\030\017\r\024)Tj 0 Tc 0 Tw (-)Tj 0.002 Tc 0.12 Tw T* (\007\016\021 \022)Tj /Span<>> BDC ( )Tj EMC [(\024\002\024\f\021\030\036\027\017\016\n, \027\024 \n\024\020\031\021 \f\ \027\017\017\021\034 \026\022\021\017\r\027\024\f\021\034 \207\025)2( )]TJ 0.157 Tw T* [([36]. \215\030\024\020\030\026\n\n\026 \027\017\022\024\017\027\021\036\ \027\f\017\r\027\024\005 \b\024\007\034\002\t \(3 \030\026\026)2( )]TJ 0.19 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\027\036\007\036\035\033, 30 \n\017\027\031\021, \r)Tj /Span<>> BDC ( )Tj EMC [(\021\036\004\036\027\017\036 3 \n\036\f\016\006\036\r\) \024\022\026\026\ \035\026)2( )]TJ -0.004 Tw T* (\002\035\026\020\024\021\r\024\030\027\024\036 \r\035\017\016\027\017\036\ \027\026)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\207\025 \017)Tj /Span<>> BDC ( )Tj EMC [(\031\035\031\004\001\017\035\026)2( )]TJ 0.08 Tw T* (\022\026\004\036\f\021\r\024 \017\b \032\017\027\017 \002\036 \024\002\ \024\f\021\030\036\027\017\016 \f\017\n\023\021\024\n\024\r \026\002\024\ )Tj 0 Tc 0 Tw (-)Tj 0.002 Tc T* (\035\036\r\026\027\017\016 [37].)Tj 0 Tc 0.017 Tw T* [(\215\024\035\031\004\036\027\t )0.5(\007\026\027\027\t\036 )0.6(\024)]TJ /Span<>> BDC ( )Tj EMC 8.396 0 Td [(\002\035\026\020\024\021\r\024\030\027\024\n )0.5(\r\035\017\016\027\017\017 )0.6(\205\202 )0.5(\027\026)]TJ /Span<>> BDC ( )Tj EMC 12.398 0 Td (\023\026)Tj 0 Tw (-)Tj -0.025 Tw -20.794 -1.218 Td (\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\200\003\025. \216\024\007\034\002\026 \002\t\035\026 \027\026\017\002\024\ \035\036\036 \004\026\f\021\024 \r\t\023\024\035\027\016)Tj 0 Tw (-)Tj 0.146 Tw T* (\036\n\024\005 \007\036\016\021\036\035\034\027\024\f\021\034\033 \(57% \ \030\036\f\023\024\027\007\036\027\021\024\r\), \026)Tj /Span<>> BDC ( )Tj EMC (\002\036\020/\002\036\020 )Tj -0.008 Tw T* [(\021\030\031\f\006\024\005 )0.5(\004\026\013\036 \r\f\036\020\024 \017\002\036\020\026\035\017 )0.5(\(34%\). )0.5(\204\027\024\020\017\036 \031\004\026\f\021\027\017)]TJ 0 Tw (-)Tj 0.006 Tw T* (\022\017 \()Tj /T1_1 1 Tf 0 Tw (n)Tj /T1_0 1 Tf 0.006 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (677,78%\) \f\024\024\002\013\017\035\017, \004\021\024 \200\003\025 \024\ \020\030\026\027\017\004\017\r\026\033\021 \017\b )Tj 0.025 Tw T* (\205\202 \023\024)Tj /Span<>> BDC ( )Tj EMC (\030\026\035\017\004\027\t\n \023\030\017\004\017\027\026\n, \r\022\035\ \033\004\026\016 \002\024\035\034 \r)Tj /Span<>> BDC ( )Tj EMC (\032\017\r\024\021\036/)Tj 0.113 Tw T* [(\f\031\f\021\026\r\026\b )0.6(\(70%\), )0.5(\031\f\021\026\035\024\f\021\034 )0.6(\(69%\), )0.5(\024\002\024\f\021\030\036\027\017\036 )0.6(\002\024\035\036)]TJ 0 Tw (-)Tj -0.016 Tw T* (\027\017 \(63%\) \017)Tj /Span<>> BDC ( )Tj EMC (\023\024\r\t\001\036\027\027\031\033 \023\024\021\030\036\002\027\024\f\021\ \034 \r)Tj /Span<>> BDC ( )Tj EMC (\021\031\026\035\036\021\036 \(61%\) )Tj 0.077 Tw T* ([38]. \211)Tj /Span<>> BDC ( )Tj EMC (\027\036\022\024\021\024\030\t\b \023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\200\003\025 \n\024\020\031\021 \002\t\021\034 \024\020\030\026)Tj 0 Tw (-)Tj 0.033 Tw T* (\027\017\004\036\027\017\016 \023\024)Tj /Span<>> BDC ( )Tj EMC (\022\024\035\017\004\036\f\021\r\031 \017)Tj /Span<>> BDC ( )Tj EMC (\017\027\021\036\027\f\017\r\027\024\f\021\017 \205\211, \022\024\021\024\ \030\t\036 )Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0 Tw 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\214)10(\211\036\033 \035\030\032\t\033)30(\b)42(\032)-21(\240\033\233)]TJ 57.136 0 Td (REVIEW)Tj -57.136 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 23, \023\0221)69(, 202)69(4)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 23, \023\0221)69(, 202)69(4)]TJ /T1_4 1 Tf 25 0 0 25 20.8028 56.0378 Tm (154)Tj ET endstream endobj 671 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\210\220\222\220\017\016\006\n\220\016 \215\221\002\013\217\001\016\001\220\ \205 \n\013\n \232\225\225\016\n)-9.9(\026\220\r\001\013\205 )]TJ 0 -1 TD [(\013\201\230\212\r\013\001\026\001\013\205 \026)11(\016\002\013\221\220\205 \221\002\220\022\002\016\024\220\006\006\220\220\ \r\025\006\221\013\007\220\026)11(\016\007\216\001\020\207 )]TJ T* [(\222\013\f\025\007\016\r\013\001\220\203 \n\220\016\017\001\220\n\013 \(\ \025\f\222\025\002 \007\220\026)11(\016\002\013\026)-19.9(\215\002\020\))]TJ 43.88 2 Td [(Ph)31(y)10(sical e)21(x)10(er)31(cises as an ef)-30.9(fectiv)12(e adju)10(v)10(ant )]TJ 2.526 -1 Td [(th)11(er)21(apy of IBD in r)31.1(emission \(r)31(e)11(vie)11(w\))]TJ ET 0 0 0 1 K /GS1 gs q 1 0 0 1 42.5197 720.7159 cm 0 0 m 453.543 0 l S Q BT 0 0 0 1 k /T1_1 1 Tf 0.023 Tw 8 0 0 8 42.5197 731.2159 Tm [(Pisk)11(arevsky A)14(v)13(e., 47, S)28(t. P)15(etersburg, 195067, R)22(ussia; e-mail: S.K)18(ostyuk)17(evich@szgmu.ru)]TJ 0 Tw 0 -2.792 TD (\200\026\024\026 \033\n\t\024\205\033\023\031\021\025\002)Tj /Span<>> BDC ( )Tj EMC (\227 29.11.2023)Tj /Span<>> BDC ( )Tj EMC 19.488 0 Td (\n\t\023\031 \030\n\032\026\005\n\024\013\025)Tj /Span<>> BDC ( )Tj EMC (\227 19.12.2023)Tj /Span<>> BDC ( )Tj EMC 18.78 0 Td (\032\025\021\002\024\n \013)Tj /Span<>> BDC ( )Tj EMC (\033\205\005\023\025\013\026\203\025\025)Tj /Span<>> BDC ( )Tj EMC (\227 12.02.2024)Tj ( )Tj -38.268 -1.375 Td (Received)Tj /Span<>> BDC ( )Tj EMC (\227 29.11.2023)Tj /Span<>> BDC ( )Tj EMC 19.488 0 Td (Revised)Tj /Span<>> BDC ( )Tj EMC (\227 19.12.2023)Tj /Span<>> BDC ( )Tj EMC 18.78 0 Td (Accepted for publication)Tj /Span<>> BDC ( )Tj EMC (\227 12.02.2024)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 42.5896 663.9399 Tm (\023\023\034\226\034\022\031\034)Tj 0 0 0 1 k /GS1 gs /T1_3 1 Tf 0 Tc 0.243 Tw 10 0 0 10 42.5197 639.5839 Tm (\200\024\f\023\026\035\017\021\036\035\034\027\t\036 \026\002\024\035\036\ \r\026\027\017\016 \022\017\001\036\004\027\017\022\026 \023\030\036\007\ \f\021\026\r)Tj 0 Tw (-)Tj 0.605 Tw 0 -1.218 TD [(\035\016\033\021 )0.6(\f\024\002\024\005 \017\n\n\031\027\024\r\024\f\023\026\035\017\021\036\035\ \034\027\t\036 )0.6(\b\030\024\027\017\004\036\f\022\017\036 )]TJ 0.422 Tw T* (\026\002\024\035\036\r\026\027\017\036 \032\036\035\031\007\024\004\027\ \024-\022\017\001\036\004\027\024\020\024 \021\030\026\022\021\026 \(\240\ \025\230\); )Tj 0.117 Tw 0 -1.218 TD (\r\022\035\033\004\026\033\021 \017)Tj /Span<>> BDC ( )Tj EMC (\207\025, \017)Tj /Span<>> BDC ( )Tj EMC (\247\025 [1,2]. \215\024)Tj /Span<>> BDC ( )Tj EMC (\220\021\017\024\035\024\020\017\017 \200\003\025 \023\030\036\007)Tj 0 Tw (-)Tj 0.488 Tw 0 -1.218 TD (\023\024\035\026\020\026\036\021\f\016, \004\021\024 \r\026\017\n\024\007\ \036\005\f\021\r\017\036 \020\036\027\024\r, \235\026\022\021\024\030\024\ \r )Tj 0.116 Tw T* [(\024\022\030\031\032\026\033\013\036\005 \f\030\036\007\t, \007\017\f\235\ \031\027\022\006\017\017 )0.5(\017\n\n\031\027\027\024\005 \f\017\f\021\036\n\t )]TJ -0.044 Tw T* (\f\035\017\017\f\021\t\b \024\002\024\035\024\004\036\022 \017)Tj /Span<>> BDC ( )Tj EMC (\017\n\036\027\036\027\017\005 \n\017\022\030\024\002\017\024\021\t \022\ \017\001\036\004)Tj 0 Tw (-)Tj 0.352 Tw T* (\027\017\022\026 \f\023\024\f\024\002\f\021\r\031\036\021 \030\026\r\017\ \021\017\033 \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\020\030\036\f\f\017\030\024\r\026\027\017\033 )Tj 0.163 Tw 0 -1.218 TD (\200\003\025 [3]. \222\n\036\033\021\f\016 \007\026\027\027\t\036, \004\021\ \024 \027\026)Tj /Span<>> BDC ( )Tj EMC (\b\030\024\027\017\004\036\f\022\024\036 \r\024\f)Tj 0 Tw (-)Tj 0.249 Tw 0 -1.218 TD (\023\026\035\036\027\017\036 \022\017\001\036\004\027\017\022\026 \024\022\ \026\t\r\026\036\021 \r\035\017\016\027\017\036 \027\026\030\031\001\036\ \027\017\036 )Tj -0.003 Tw 0 -1.218 TD (\030\036\020\031\035\016\006\017\017 \024\f\017 \022\017\001\036\004\027\ \017\022-\n\024\020 [4], \004\021\024 \023\030\017\r\024\007\017\021 \022\ )Tj /Span<>> BDC ( )Tj EMC (\023\024)Tj 0 Tw (-)Tj 0.407 Tw T* (\021\036\030\036 \030\026\r\027\024\r\036\f\017\016 \n\036\032\007\031 \020\ \017\023\024\021\026\035\026\n\024-\020\017\023\024\235\017\026\030\027\ \024-)Tj 0.065 Tw T* [(\027\026\007\023\024\004\036\004\027\017\022\024\r\024\005 )0.6(\024\f\034\033 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 10.821 0 Td [(\035\017\n\002\017\004\036\f\022\024\005 )0.6(\f\017\f\021\036\n\024\005 )0.5([5], )]TJ 0.322 Tw -10.821 -1.218 Td (\017)Tj /Span<>> BDC ( )Tj EMC (\007\017\f\002\026\035\026\027\f\031 \f\017\n\023\026\021\017\022\024-\023\ \026\030\026\f\017\n\023\026\021\017\004\036\f\022\024\005 \027\036\030\r\ )Tj 0 Tw (-)Tj T* (\027\024\005 \f\017\f\021\036\n\t [6].)Tj 0.166 Tw T* (\215\026\006\017\036\027\021\t \f)Tj /Span<>> BDC ( )Tj EMC (\200\003\025 \f\021\030\026\007\026\033\021 \024\021 \001\017\030\024\022\ \024\020\024 \f\023\036\022\021\030\026 \007\024)Tj 0 Tw (-)Tj 0.163 Tw T* (\023\024\035\027\017\021\036\035\034\027\t\b \030\026\f\f\021\030\024\005\ \f\021\r, \022\024\021\024\030\t\036 \n\024\020\031\021 \002\t\021\034 \r\ \t)Tj 0 Tw (-)Tj 0.125 Tw T* (\r\026\027\t \026\002\024\035\036\r\026\027\017\036\n, \023\024\002\024\ \004\027\t\n \007\036\005\f\021\r\017\036\n \035\036\022\026\030\f\021\r\ )Tj 0.118 Tw T* (\017\035\017 \027\036\007\024\f\021\026\021\022\024\n \235\017\017\004\036\ \f\022\024\005 \026\022\021\017\r\027\024\f\021\017 \(\205\202\). \216\024\ \021\016 )Tj -0.032 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\023\024\f\035\036\007\027\017\036 \020\024\007\t \023\024\016\r\017\035\ \017\f\034 \027\024\r\t\036 \023\026\021\024\020\036\027\036\021\017\004\ \036\f\022\017\036 )Tj 0.124 Tw T* [(\023\024\007\b\024\007\t \007\035\016 )0.5(\035\036\004\036\027\017\016 )0.5(\200\003\025, \024\022\024\035\024 \023\024\035\024\r\017\027\t )0.5(\023\026\006\017\036\027)]TJ 0 Tw (-)Tj 0.159 Tw T* (\021\024\r \027\036 \024\021\r\036\004\026\033\021 \027\026)Tj /Span<>> BDC ( )Tj EMC (\220\021\024 \035\036\004\036\027\017\036, \026)Tj /Span<>> BDC ( )Tj EMC (\004\026\f\021\034 \023\026\006\017\036\027\021\024\r )Tj 0.097 Tw T* (\253\021\036\030\016\033\021\273 \024\021\r\036\021, \004\021\024 \021\030\ \036\002\031\036\021 \023\036\030\036\b\024\007\026 \027\026)Tj /Span<>> BDC ( )Tj EMC (\027\024\r\t\036 \f\b\036)Tj 0 Tw (-)Tj 0.242 Tw T* (\n\t, \023\024\017\f\022 \027\024\r\t\b \235\026\030\n\026\022\024\026\020\ \036\027\021\024\r. \215\026\006\017\036\027\021\t \004\026\f\021\024 )Tj 0.124 Tw T* (\024\f\021\026\033\021\f\016 \030\026\024\004\026\030\024\r\026\027\027\ \t\n\017 \027\036\023\024\035\027\t\n \017\f\004\036\027\024\r\036\027\017\ )Tj 0 Tw (-)Tj 0.109 Tw T* (\036\n \f\017\n\023\021\024\n\024\r \017)Tj /Span<>> BDC ( )Tj EMC (\017\013\031\021 \026\035\034\021\036\030\027\026\021\017\r\027\t\036 \017\ \035\017 \007\024\023\024\035\027\017)Tj 0 Tw (-)Tj 0.024 Tw T* (\021\036\035\034\027\t\036 \235\024\030\n\t \021\036\030\026\023\017\017\ , \022\024\021\024\030\t\036 \n\024\020\035\017 \002\t \031\035\031\004\001\ \017\021\034 )Tj 0.097 Tw T* (\017\b \f\017\n\023\021\024\n\t \017\035\017 \023\024\n\024\004\034 \017\ \n \023\024\007\007\036\030\032\017\r\026\021\034 \023\036\030\017\024\007\ \t )Tj 0 Tw T* (\030\036\n\017\f\f\017\017 [7].)Tj 0.04 Tw T* (\217\024\035\034 \205\202 \r)Tj /Span<>> BDC ( )Tj EMC (\022\026\004\036\f\021\r\036 \021\036\030\026\023\036\r\021\017\004\036\f\ \022\024\020\024 \r\026\030\017\026\027\021\026 \024\f\021\026)Tj 0 Tw (-)Tj 0.058 Tw T* (\036\021\f\016 \027\036\007\024\f\021\026\021\024\004\027\024 \017\031\004\ \036\027\027\024\005. \200)Tj /Span<>> BDC ( )Tj EMC (\217\205 \027\036\021 \022\035\017\027\017\004\036\f\022\017\b )Tj -0.028 Tw T* (\030\036\022\024\n\036\027\007\026\006\017\005 \023\024)Tj /Span<>> BDC ( )Tj EMC [(\235\017\017\004\036\f\022\024\005 )0.5(\030\036\026\002\017\035\017\021\026\006\017\017 \002\024\035\034\027\t\b\ )]TJ -0.022 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\200\003\025 [8]. \215\030\017)Tj /Span<>> BDC ( )Tj EMC (\021\024\n, \004\021\024 \205\202 \f\027\017\032\026\036\021 \030\017\f\022\ \030\026\r\017\021\017\016 \200\003\025 )Tj 0.217 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\030\017\f\022 \026\022\021\017\r\027\024\020\024 \026\002\024\035\036\r\ \026\027\017\016 \r)Tj /Span<>> BDC ( )Tj EMC (\002\031\007\031\013\036\n [9]. \203\036\021 )Tj 0.204 Tw T* (\022\024\027\022\030\036\021\027\t\b \031\022\026\026\027\017\005 \007\035\ \016 \022\035\017\027\017\006\017\f\021\024\r \024\021\027\024\f\017\021\ \036\035\034)Tj 0 Tw (-)Tj 0.292 Tw T* (\027\024 \024\023\021\017\n\026\035\034\027\024\020\024 \030\036\032\017\ \n\026 \031\023\030\026\032\027\036\027\017\005, \017\b \023\030\024\007\ \024\035)Tj 0 Tw (-)Tj 0.295 Tw T* (\032\017\021\036\035\034\027\024\f\021\017, \004\026\f\021\024\021\t \017\ \035\017 \017\027\021\036\027\f\017\r\027\024\f\021\017, \022\024\021\024\ \030\t\036 )Tj -0.021 Tw T* (\016\r\035\016\033\021\f\016 \027\026\017\002\024\035\036\036 \023\024\007\ \b\024\007\016\013\017\n\017 \007\035\016 \023\024\035\031\004\036\027\017\ \016 \002\035\026)Tj 0 Tw (-)Tj 0.149 Tw T* [(\020\024\023\030\017\016\021\027\t\b \017\n\036\027\036\027\017\005, )0.5(\023\024\220\021\024\n\031 \027\036\031\007\017\r\017\021\036\035\034\027\ \024, )0.5(\004\021\024 )]TJ -0.022 Tw 0 -1.218 TD [(\031\023\030\026\032\027\036\027\017\016 )0.6(\030\036\007\022\024 )0.5(\024\002\f\031\032\007\026\033\021\f\016 )0.6(\020\026\f\021\030\024\220\027\021\036\030\024\035\024\020\026\n\017, )]TJ 0.197 Tw 0 -1.218 TD [(\r\030\026\004\026\n\017 )0.6(\024\002\013\036\005 )0.5(\023\030\026\022\021\017\022\017 )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC 12.169 0 Td [(\007\030\031\020\017\n\017 )0.6(\n\036\007\017\006\017\027\f\022\017\n\017 )]TJ 0 Tw -12.169 -1.218 Td (\030\026\002\024\021\027\017\022\026\n\017.)Tj /T1_4 1 Tf 0.023 Tw 0 -2.436 TD (\026\f\t\235\b\t\r \203\032 \b\004)Tj /Span<>> BDC ( )Tj EMC (\002\217\212\004\f\r\b\t\r \212\006\t)Tj /Span<>> BDC ( )Tj EMC (\026\033\021)Tj /T1_3 1 Tf 0.19 Tw 0 -1.218 TD (\025\026\022 \017\r\036\f\021\027\024 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\035\036\004\036\027\017\017 \n\027\024\020\017\b \b\030\024\027\017\004\ \036\f\022\017\b \026)Tj 0 Tw (-)Tj 0.215 Tw T* (\002\024\035\036\r\026\027\017\005 \235\017\017\004\036\f\022\017\036 \031\ \023\030\026\032\027\036\027\017\016 \(\205\211\) \n\024\020\031\021 \017\ \f)Tj 0 Tw (-)Tj 0.204 Tw T* (\023\024\035\034\024\r\026\021\034\f\016 \r)Tj /Span<>> BDC ( )Tj EMC (\022\026\004\036\f\021\r\036 \023\024\007\007\036\030\032\017\r\026\033\013\ \036\005 \021\036\030\026\023\017\017 )Tj 0.232 Tw 23.244 58.454 Td (\007\035\016 \023\026\006\017\036\027\021\024\r. \203\024 \f\031\013\036\ \f\021\r\031\036\021 \n\026\035\024 \017\f\f\035\036\007\024\r\026\027\017\ \005, )Tj 0.151 Tw T* [(\017\031\004\026\033\013\017\b )0.5(\r\035\017\016\027\017\036 )0.5(\205\202 \027\026)]TJ /Span<>> BDC ( )Tj EMC [(\f\r\016\026\027\027\024\036 )0.5(\f\024 \007\024\030\024\r\034\036\n )]TJ 0.195 Tw 0 -1.218 TD (\022\026\004\036\f\021\r\024 \032\017\027\017 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\200\003\025. \215\024\035\024\032\017\021\036\035\034\027\t\036 \220\235\ \235\036\022\021\t )Tj 0 Tw 0 -1.218 TD (\205\211 \027\026)Tj /Span<>> BDC ( )Tj EMC (\240\025\230 \n\026\035\024 \017\031\004\036\027\t.)Tj -0.075 Tw 0 -1.218 TD [(\222\f\f\035\036\007\024\r\026\027\017\016 )0.5(\f\030\036\007\017 \035\033\007\036\005, )0.5(\027\036 \f\021\030\026\007\026\033\013\017\b )0.5(\200\003\025, )0.5(\023\024\022\026)]TJ 0 Tw (-)Tj 0.036 Tw 0 -1.218 TD (\026\035\017, \004\021\024 \031\023\030\026\032\027\036\027\017\016 \027\ \017\022\024\005 \017)Tj /Span<>> BDC ( )Tj EMC (\f\030\036\007\027\036\005 \017\027\021\036\027\f\017\r\027\024)Tj 0 Tw (-)Tj 0.016 Tw 0 -1.218 TD (\f\021\017 \031\035\031\004\001\026\033\021 \017\n\n\031\027\027\031\033\ \235\031\027\022\006\017\033 [10] \017)Tj /Span<>> BDC ( )Tj EMC (\f\023\024\f\024\002\f\021\r\031)Tj 0 Tw (-)Tj 0.14 Tw 0 -1.218 TD (\033\021 \f\027\017\032\036\027\017\033 \f\n\036\030\021\027\024\f\021\017\ \024\021 \r\f\036\b \023\030\017\004\017\027, \r)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\r\031\033 )Tj 0.177 Tw 0 -1.218 TD (\024\004\036\030\036\007\034, \026)Tj /Span<>> BDC ( )Tj EMC (\f\004\036\021 \026\013\017\021\t \024\021 \002\024\035\036\027\036\005\ \f\017\f\021\036\n\t \022\030\024)Tj 0 Tw (-)Tj 0.111 Tw 0 -1.218 TD [(\r\024\024\002\030\026\013\036\027\017\016 )0.5(\(\207\221\025\) )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC 9.459 0 Td [(\f\026\b\026\030\027\024\020\024 )0.5(\007\017\026\002\036\021\026 )0.6(2 )0.5(\021\017\023\026 )0.5(\(\221\212 )]TJ 0.231 Tw -9.459 -1.218 Td (2\) [11]. \215\031\f\022\024\r\t\n \n\036\b\026\027\017\n\024\n \016\r\035\ \016\033\021\f\016 \n\017\024\022\017\027\t, )Tj -0.023 Tw 0 -1.218 TD (\023\036\030\r\t\005 \r\t\007\036\035\036\027\027\t\005 \f\030\036\007\017\ \027\017\b \006\017\021\024\022\017\027 IL-6, \022\024\021\024\030\t\005\ )Tj 0.259 Tw 0 -1.218 TD [(\023\030\024\007\031\006\017\030\031\036\021\f\016 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC (\r\t\f\r\024\002\024\032\007\026\036\021\f\016 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\f\024\022\030\026\013\036\027\017\017 )Tj 0.364 Tw 0 -1.218 TD (\r\024\035\024\022\024\027 \f\022\036\035\036\021\027\t\b \n\t\001\006 [\ 11,12]. \215\024\021\036\027\006\017\026\035\034\027\t\036 )Tj 0.361 Tw 0 -1.218 TD (\n\036\b\026\027\017\n\t \023\024\035\024\032\017\021\036\035\034\027\024\ \020\024 \220\235\235\036\022\021\026 \026\022\035\033\004\026\033\021\f\ \016 )Tj -0.038 Tw 0 -1.218 TD (\r)Tj /Span<>> BDC ( )Tj EMC (\021\024\n, \004\021\024 \031\023\030\026\032\027\036\027\017\016 \031\n\ \036\030\036\027\027\024\005 \017\027\021\036\027\f\017\r\027\024\f\021\017\ \024\022\026)Tj 0 Tw (-)Tj -0.008 Tw 0 -1.218 TD [(\t\r\026\033\021 )0.5(\023\030\024\021\017\r\024\r\024\f\023\026\035\017\021\036\035\034\027\024\ \036 )0.7(\007\036\005\f\021\r\017\036, )0.5(\022\026\022 )0.5(\026)]TJ /Span<>> BDC ( )Tj EMC 20.356 0 Td (\f\004\036\021 )Tj 0.09 Tw -20.356 -1.218 Td (\031\n\036\027\034\001\036\027\017\016 \r\017\f\006\036\030\026\035\034\027\ \024\020\024 \032\017\030\026, \021\026\022 \017)Tj /Span<>> BDC ( )Tj EMC (\026 \f\004\036\021 \f\027\017)Tj 0 Tw (-)Tj 0.309 Tw 0 -1.218 TD [(\032\036\027\017\016 )0.6(\023\024\f\035\036\007\031\033\013\036\020\024 )0.5(\r\t\f\r\024\002\024\032\007\036\027\017\016 )0.6(\023\030\024\r\024\f\023\026\035\017)]TJ 0 Tw (-)Tj 0.133 Tw 0 -1.218 TD (\021\036\035\034\027\t\b \006\017\021\024\022\017\027\024\r \017)Tj /Span<>> BDC ( )Tj EMC (\r\t\f\r\024\002\024\032\007\036\027\017\016 \n\017\024\022\017\027\024\r\ , \021\026)Tj 0 Tw (-)Tj -0.005 Tw 0 -1.218 TD (\022\017\b \022\026\022 IL-6, \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\022\026\032\007\024\005 \021\030\036\027\017\030\024\r\022\036. \207\t\035\ \024 \023\024\022\026\026\027\024, )Tj 0.048 Tw 0 -1.218 TD (\004\021\024 IL-6, \r\t\f\r\024\002\024\032\007\026\036\n\t\005 \r\024 \r\ \030\036\n\016 \205\211, \031\r\036\035\017\004\017\r\026\036\021 )Tj 0.059 Tw 0 -1.218 TD (\r\t\f\r\024\002\024\032\007\036\027\017\036 \020\035\033\022\026\020\024\ \027\024\023\024\007\024\002\027\t\b \023\036\023\021\017\007\024\r, \022\ \024\021\024)Tj 0 Tw (-)Tj 0.005 Tw 0 -1.218 TD (\030\t\036 \016\r\035\016\033\021\f\016 \021\030\024\235\017\004\036\f\022\ \017\n\017 \235\026\022\021\024\030\026\n\017, \f\r\016\026\027\027\t\n\ \017 )Tj -0.015 Tw 0 -1.218 TD (\f)Tj /Span<>> BDC ( )Tj EMC (\r\024\f\f\021\026\027\024\r\035\036\027\017\036\n \023\024\r\030\036\032\ \007\036\027\027\024\005 \f\035\017\017\f\021\024\005 \024\002\024\035\024\ \004)Tj 0 Tw (-)Tj 0 -1.218 TD (\022\017 \022\017\001\036\004\027\017\022\026 [13].)Tj 0.008 Tw 0 -1.218 TD (\200 \027\026\f\021\024\016\013\036\036 \r\030\036\n\016 \f\021\026\035\024\ \016\f\027\024, \004\021\024 \f\035\026\002\024\r\t\030\026\032\036\027\ \027\024\036 )Tj 0.127 Tw 0 -1.218 TD (\b\030\024\027\017\004\036\f\022\024\036 \r\024\f\023\026\035\036\027\017\ \036 \016\r\035\016\036\021\f\016 \022\035\033\004\036\r\t\n \253\017\020\ \030\024)Tj 0 Tw (-)Tj 0.18 Tw 0 -1.218 TD (\022\024\n\273 \r)Tj /Span<>> BDC ( )Tj EMC (\023\026\021\024\020\036\027\036\036 \002\024\035\034\001\017\027\f\021\ \r\026 \b\030\024\027\017\004\036\f\022\017\b \027\036\017\027)Tj 0 Tw (-)Tj 0.014 Tw 0 -1.218 TD (\235\036\022\006\017\024\027\027\t\b \026\002\024\035\036\r\026\027\017\ \005 \(\216\203\222\003\), \022\024\021\024\030\t\036 \r\022\035\033\004\ \026\033\021 )Tj 0.255 Tw 0 -1.218 TD (\207\221\025, \027\036\022\024\021\024\030\t\036 \r\017\007\t \030\026\022\ \026, \027\026\023\030\017\n\036\030, \030\026\022 \021\024\035\f\021\024\ \005 )Tj 0.231 Tw 0 -1.218 TD (\022\017\001\022\017, \030\026\022 \n\024\035\024\004\027\024\005 \032\036\ \035\036\t, \221\212 2. \221\027\017\032\036\027\017\036 \f\017)Tj 0 Tw (-)Tj 0.076 Tw 0 -1.218 TD (\f\021\036\n\027\024\020\024 \r\024\f\023\026\035\036\027\017\016 \027\026\ \002\035\033\007\026\035\024\f\034 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\205\202 \017)Tj /Span<>> BDC ( )Tj EMC (\031 \023\030\026\022)Tj 0 Tw (-)Tj 0.107 Tw 0 -1.218 TD (\021\017\004\036\f\022\017 \007\024\030\024\r\t\b \035\033\007\036\005 \ [14]. \215\030\036\007\024\021\r\030\026\013\036\027\017\036 \017\035\017\ )Tj 0.363 Tw 0 -1.218 TD (\024\f\035\026\002\035\036\027\017\036 \r\024\f\023\026\035\036\027\017\016\ \016\r\035\016\036\021\f\016 \r\036\030\024\016\021\027\t\n \r\026\032)Tj 0 Tw (-)Tj 0.341 Tw 0 -1.218 TD (\027\t\n \n\036\b\026\027\017\n\024\n \026\013\017\021\t \024\021 \030\ \026\r\017\021\017\016 \216\203\222\003 [15]. )Tj 0.095 Tw 0 -1.218 TD (\207\035\026\020\024\007\026\030\016 \220\021\017\n \032\036 \n\036\b\026\ \027\017\n\026\n, \205\211 \n\024\020\031\021 \024\022\026\t\r\026\021\ \034 )Tj 0.017 Tw 0 -1.218 TD [(\023\024\035\024\032\017\021\036\035\034\027\024\036 )0.7(\r\035\017\016\027\017\036 )0.6(\022\026\022 )0.5(\027\026)]TJ /Span<>> BDC ( )Tj EMC 13.184 0 Td [(\030\026\r\017\021\017\036, )0.6(\021\026\022 )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC 6.504 0 Td [(\027\026 )0.6(\021\036)]TJ 0 Tw (-)Tj 0.095 Tw -19.688 -1.218 Td (\004\036\027\017\036 \200\003\025 [16]. \203\036\f\n\024\021\030\016 \027\ \026)Tj /Span<>> BDC ( )Tj EMC (\023\026\021\024\035\024\020\017\004\036\f\022\024\036 \027\026\004\036\ )Tj 0 Tw (-)Tj 0.137 Tw 0 -1.218 TD (\027\017\036 \023\030\024\r\024\f\023\026\035\017\021\036\035\034\027\024\ \020\024 IL-6 \r)Tj /Span<>> BDC ( )Tj EMC (\b\030\024\027\017\004\036\f\022\024\n \r\024\f\023\026)Tj 0 Tw (-)Tj 0.055 Tw 0 -1.218 TD (\035\017\021\036\035\034\027\024\n \023\030\024\006\036\f\f\036 \023\030\ \017)Tj /Span<>> BDC ( )Tj EMC (\200\003\025 [17,18], \r\t\030\026\002\024\021\022\026 IL-6 )Tj -0.052 Tw 0 -1.218 TD (\r)Tj /Span<>> BDC ( )Tj EMC [(\f\022\036\035\036\021\027\t\b )0.5(\n\t\001\006\026\b )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC [(\024\021\r\036\021 )0.5(\027\026)]TJ /Span<>> BDC ( )Tj EMC [(\205\202, )0.5(\r\036\030\024\016\021\027\024, )0.5(\016\r\035\016\036\021\f\016 )]TJ -0.014 Tw 0 -1.218 TD (\023\030\024\021\017\r\024\r\024\f\023\026\035\017\021\036\035\034\027\024\ \005 \017)Tj /Span<>> BDC ( )Tj EMC (\024\023\030\036\007\036\035\016\036\021\f\016 \023\024\035\024\032\017\021\ \036\035\034)Tj 0 Tw (-)Tj 0.169 Tw 0 -1.218 TD (\027\024\005 \030\024\035\034\033 \f\r\016\026\027\027\t\b \f)Tj /Span<>> BDC ( )Tj EMC (\205\211 \n\036\021\026\002\024\035\017\004\036\f\022\017\n\017 \017\n\036\ )Tj 0 Tw (-)Tj 0.108 Tw 0 -1.218 TD (\027\036\027\017\016\n\017 [19]. \221\017\027\021\036 \n\t\001\036\004\027\ \024\020\024 IL-6 \023\030\036\007\001\036\f\021\r\031\036\021 )Tj -0.034 Tw 0 -1.218 TD (\022\026\f\022\026\007\031 \f\017\035\034\027\024\007\036\005\f\021\r\031\ \033\013\017\b \023\030\024\021\017\r\024\r\024\f\023\026\035\017\021\036\ \035\034\027\t\b )Tj 0.128 Tw 0 -1.218 TD (\006\017\021\024\022\017\027\024\r IL-10 \017)Tj /Span<>> BDC ( )Tj EMC (\026\027\021\026\020\024\027\017\f\021\026 \030\036\006\036\023\021\024\030\ \026 \222\214-1 \(IL-)Tj 0.373 Tw 0 -1.218 TD [(1R)-10(a\) \007\035\016 \f\024\007\026\027\017\016 \023\030\024\021\017\r\024\r\ \024\f\023\026\035\017\021\036\035\034\027\024\005 \f\030\036\007\t )]TJ 0.115 Tw 0 -1.218 TD ([20]. \200)Tj /Span<>> BDC ( )Tj EMC (\004\026\f\021\027\024\f\021\017, IL-10 \017)Tj /Span<>> BDC ( )Tj EMC [(IL-1R)-10(a \f\027\017\032\026\033\021 \023\036\030\036\007\026\004\031 )]TJ 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 0 Tw 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\214)10(\211\036\033 \035\030\032\t\033)30(\b)42(\032)-21(\240\033\233)]TJ 57.136 0 Td (REVIEW)Tj /T1_5 1 Tf 25 0 0 25 505.4271 56.0378 Tm (153)Tj ET endstream endobj 668 0 obj [674 0 R] endobj 669 0 obj <>stream q /GS0 gs /Fm0 Do Q 0 0 0 1 K 1 j 1 J [0 2.997]0 d /GS1 gs q 1 0 0 1 74.3631 416.141 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 71.3661 416.141 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q [0 2.997]0 d q 1 0 0 1 74.3631 378.9332 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 71.3661 378.9332 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q [0 2.997]0 d q 1 0 0 1 74.3631 146.179 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 71.3661 146.179 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q [0 2.997]0 d q 1 0 0 1 74.3631 118.5711 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 71.3661 118.5711 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q BT 0 0 0 1 k /T1_0 1 Tf 10 0 0 10 70.8661 724.8299 Tm (https://doi.org/10.33878/2073-7556-2024-23-1-152-161)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0.023 Tw 19 0 0 19 74.95 695.3259 Tm [(\210\220\222\220\017\016\006\n\220\016 \215\221\002\013\217\001\016\001\220\ \205 \n\013\n \232\225\225\016\n)-10(\026\220\r\001\013\205 \013\201\230\212\r\013\001\026\001\013\205 )]TJ 0.742 -1.105 Td [(\026)11(\016\002\013\221\220\205 \221\002\220\022)-23.2(\002\016\024\220\006\006\220\220 \r\025\006\221\013\007\220\026)11.1(\016\007\216\001\020\207 \222\013\f\025\007\016\r\013\001\220\203 )]TJ 4.418 -1.105 Td [(\n\220\016\017\001\220\n\013 \(\025\f\222\025\002 \007\220\026)11(\016\002\013\026)-19.9(\215\002\020\))]TJ 0 0 0 1 k /GS1 gs 14 0 0 14 70.8661 628.822 Tm [(\037)31(\025\006)-10(\026\212\n\016\r\220\017\022)-23.2(\021.\004., \214\013\n\215\007\220\001\022)-23.2(\030.\031)72(.)]TJ 10 0 0 10 70.8661 611.1527 Tm [(\210\031\214)21(\036)20(\240 \004\036 \253\021\016\r\016\002\025-\211\013\221\013\201\001\020\203\ \031)52(\005)21(\240 \220\024\016\001\220 \030.\030.\022)-23.2(\005\016\017\001\220\n)10(\025\r\013\273 \005\220\001\222\201\002\013\r\013 \033\025\006\006\220\220\ \(\215\007.\022)-23.3(\037)20(\220\002\025\017\001\013\205, \201.\022)-23.2(4)103(1)69(, )]TJ 0 -1.2 TD [(\202)62(.\022)-23.3(\021\013\001\n)-9.9(\026)-42(-\034\016\026)11(\016\002\f\215\002\202)41(, 1)138(9)125(1)75(0)87(1)113(5, \033\025\006\006\220\205\))]TJ /T1_0 1 Tf 0.014 Tw 9 0 0 9 119.0551 580.6488 Tm (\216\n\t\033\026\023\025\024\031\023\022\021\020\031 \016\026\005\n\023\031\ \027\026\021\025\002 \013\025\001\031\006\021\025\013\026 \(\216\221\222\ \) \027\013\023\007\006\026\007\024 \005\n\023\031\016\021\022 \222\032\n\ \021\026 \025)Tj /Span<>> BDC ( )Tj EMC (\002\016\027\031\021\021\020\017 \013\n\023\025\024. \216\221\222 \002\027\ \023\002\007\024\t\002 )Tj -0.008 Tw 0 -1.111 TD (\004\032\n\021\025\006\031\t\013\025\003\025 \005\n\023\031\016\021\002\003\ \025 \t)Tj /Span<>> BDC ( )Tj EMC (\024\032\026\031\013\024\n\032\025\031\017 \032\031\003\025\t\t\025\025 \ \025)Tj /Span<>> BDC ( )Tj EMC (\032\031\203\025\030\025\027\026. \240\031\030\025\013\026\003\031\021\024\ \n\016\021\026\002 \024\031\032\026\033\025\002 \216\221\222 \021\031\030\ \n\t\024\026\024\n\006)Tj 0 Tw (-)Tj 0.022 Tw T* (\021\n \r\f\f\031\013\024\025\027\021\026. \207\205\211\031\t\024\027\205\ \031\024 \033\n\024\032\031\005\021\n\t\024\022 \027)Tj /Span<>> BDC ( )Tj EMC (\026\030\b\007\027\026\021\024\021\n\017 \024\031\032\026\033\025\025 \216\ \221\222. \037\031\023\022 \021\026\t\024\n\002\211\031\202\n \n\005\016\ \n\032\026 \t\n\t\024\n\002)Tj 0 Tw (-)Tj -0.035 Tw T* (\023\026 \027)Tj /Span<>> BDC ( )Tj EMC (\024\n\003, \006\024\n\005\020 \033\032\031\030\t\024\026\027\025\024\022\ \032\n\023\022 \f\025\016\025\006\031\t\013\025\004 \205\033\032\026\204\ \021\031\021\025\017 \025)Tj /Span<>> BDC ( )Tj EMC (\025\004 \027\023\025\002\021\025\031 \021\026)Tj /Span<>> BDC ( )Tj EMC (\216\221\222. \216)Tj /Span<>> BDC ( )Tj EMC (\r\024\n\017 \t\027\002\016\025 \027\031\030\245\024\t\002 \033\n\025\t\013\ )Tj 0.046 Tw T* (\030\n\033\n\023\021\025\024\031\023\022\021\020\004 \025\021\t\024\032\205\ \003\031\021\024\n\027 \030\023\002 \033\n\027\020\001\031\021\025\002 \006\ \026\t\024\n\024\020 \030\n\t\024\025\204\031\021\025\002 \025)Tj /Span<>> BDC ( )Tj EMC (\205\030\031\032\204\026\021\025\002 \032\031\003\025\t\t\025\025. \216)Tj /Span<>> BDC ( )Tj EMC (\033\n\t\023\031\030\021\031\031 )Tj 0.015 Tw 0 -1.111 TD (\027\032\031\003\002 \033\n\023\205\006\031\021\020 \030\026\021\021\020\ \031, \006\024\n \f\025\016\025\006\031\t\013\026\002 \021\026\202\032\205\ \016\013\026 \025\021\030\205\203\025\032\205\031\024 \013\026\t\013\026\ \030 \033\032\n\024\025\027\n\027\n\t\033\026\023\025\024\031\023\022\021\ \020\004 \203\025\024\n\013\025\021\n\027, )Tj 0.086 Tw 0 -1.111 TD (\t\033\031\203\025\f\025\006\031\t\013\025 \016\026\033\205\t\013\026\031\ \003\020\017 \016\026)Tj /Span<>> BDC ( )Tj EMC (\t\006\031\024 \r\013\t\033\n\021\031\021\203\025\026\023\022\021\n\202\n\ \205\027\031\023\025\006\031\021\025\002 \003\020\001\031\006\021\n\202\ \n \025\021\024\031\032\023\031\017\013\025\021 6, \025)Tj /Span<>> BDC ( )Tj EMC (\033\032\025 \032\031\202\205)Tj 0 Tw (-)Tj 0.018 Tw T* [(\023\002\032\021\020\004 )0.6(\024\032\031\021\025\032\n\027\013\026\004 )0.5(\027)]TJ /Span<>> BDC ( )Tj EMC 9.606 0 Td [(\033\031\032\025\n\030 )0.5(\032\031\003\025\t\t\025\025 )0.6(\003\n\204\031\024 )0.6(\t\021\025\016\025\024\022 )0.5(\005\026\016\026\023\022\021\020\031 )0.6(\205\032\n\027\021\025 )0.5(\203\025\032\013\205\023\025\032\205\007\211\025\004 )0.5(\027\n\t\033\026\023\025\024\031\023\022\021\020\004 )]TJ 0.162 Tw -9.606 -1.111 Td (\003\026\032\013\031\032\n\027 \025)Tj /Span<>> BDC ( )Tj EMC (\033\n\024\031\021\203\025\026\023\022\021\n \205\003\031\021\022\001\025\ \024\022 \004\032\n\021\025\006\031\t\013\n\031 \027\n\t\033\026\023\031\ \021\025\031 \033\032\025)Tj /Span<>> BDC ( )Tj EMC (\216\221\222. \212\031\013\n\003\031\021\030\026\203\025\025 \027\032\026\ \006\026 \033\n)Tj /Span<>> BDC ( )Tj EMC (\f\025\016\025\006\031)Tj 0 Tw (-)Tj 0.101 Tw T* (\t\013\n\017 \026\013\024\025\027\021\n\t\024\025 \027)Tj /Span<>> BDC ( )Tj EMC (\033\031\032\025\n\030 \032\031\003\025\t\t\025\025 \003\n\202\205\024 \005\ \020\024\022 \r\f\f\031\013\024\025\027\021\020 \027)Tj /Span<>> BDC ( )Tj EMC (\013\026\006\031\t\024\027\031 \030\n\033\n\023\021\025\024\031\023\022\021\ \n\202\n \013\n\003\033\n\021\031\021\024\026 )Tj 0.023 Tw T* (\033\032\n\024\025\027\n\032\031\203\025\030\025\027\021\n\202\n \023\031\ \006\031\021\025\002.)Tj /T1_2 1 Tf 0.01 Tc 0.175 Tw 8 0 0 8 70.9061 465.3795 Tm [(\037\036\035\034\033\032\031\033)5( )0.6(\030\036\027\032\026:)]TJ /T1_0 1 Tf 0 Tc 0.18 Tw 8.649 0 Td [( )0.6(\027\n\t\033\026\023\025\024\031\023\022\021\020\031 )0.6(\016\026\005\n\023\031\027\026\021\025\002 )0.7(\013\025\001\031\006\021\025\013\026, )0.6(\005\n\023\031\016\021\022 )0.6(\222\032\n\021\026, )0.6(\002\016\027\031\021\021\020\017 )0.6(\013\n\023\025\024, )0.6(\f\025\016\025\006\031\t\013\026\002 )0.7(\021\026\202\032\205\016\013\026, )0.6(\026\030\b\007\027\026\021\024\021\026\002 )]TJ 0 Tw -8.654 -1.2 Td (\024\031\032\026\033\025\002)Tj /T1_2 1 Tf 0.01 Tc 0.018 Tw 0.005 -1.909 Td [(\037\027\025\024\036\023\037\022)5( \023\025\022\033\021\033\030\027\032:)]TJ /T1_0 1 Tf 0 Tc 0.023 Tw 10.401 0 Td ( \026\027\024\n\032\020 \016\026\002\027\023\002\007\024 \n\005 \n\024\t\ \205\024\t\024\027\025\025 \013\n\021\f\023\025\013\024\026 \025\021\024\ \031\032\031\t\n\027)Tj /T1_2 1 Tf 0.01 Tc -0.01 Tw -10.401 -1.909 Td (\024\023\025\026\025\030\023\021\027\032\026\025\023\033:)Tj /T1_0 1 Tf 0 Tc 0.023 Tw 8.655 0 Td ( \215\t\t\023\031\030\n\027\026\021\025\031 \021\031 \025\003\031\023\n \ \t\033\n\021\t\n\032\t\013\n\017 \033\n\030\030\031\032\204\013\025)Tj /T1_2 1 Tf 0.052 Tc 0.345 Tw -8.655 -2.617 Td [(\020\036\017)4.9( \016\023\022\023\021\027\032\026\025\023\017:)]TJ /T1_3 1 Tf 0.042 Tc 0.35 Tw 9.819 0 Td ( \025\024\f\021\033\022\036\r\017\004)Tj /Span<>> BDC ( )Tj EMC (\221.\200., \207\026\022\031\035\017\027)Tj /Span<>> BDC ( )Tj EMC [(\222.\206. \205\017\017\004\036\f\022\017\036 \031\023\030\026\032\027\036\ \027\017\016 \022\026\022 \220\235\235\036\022\021\017\r\027\026\016 \026\ \007\255\033\r\026\027\021\027\026\016 \021\036\030\026\023\017\016)42( )]TJ 0.023 Tc 0.176 Tw -9.824 -1.2 Td (\023\030\017)Tj /Span<>> BDC ( )Tj EMC (\030\036\n\017\f\f\017\017 \r\024\f\023\026\035\017\021\036\035\034\027\t\ \b \026\002\024\035\036\r\026\027\017\005 \022\017\001\036\004\027\017\022\ \026 \(\024\002\024\030 \035\017\021\036\030\026\021\031\030\t\). )Tj /T1_0 1 Tf -0.023 Tw (\222\n\023\n\033\032\n\013\024\n\023\n\202\025\002.)Tj /T1_3 1 Tf 0.176 Tw ( 2024; \021.)Tj /Span<>> BDC ( )Tj EMC (23, \225)Tj /Span<>> BDC ( )Tj EMC (1, \f.)Tj /Span<>> BDC ( )Tj EMC [(152\226161.)23( )]TJ -0.023 Tw 0 -1.2 TD (https://doi.org/10.33878/2073-7556-2024-23-1-152-161)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0 Tc 0.023 Tw 18 0 0 18 147.2553 352.7639 Tm [(Ph)31(y)10(sical e)21(x)10(er)31(cises as an ef)-31(fectiv)12.1(e adju)10(v)10(ant )]TJ 1.263 -1.167 Td [(th)11(er)21(apy of IBD in r)31(emission \(r)31(e)11(vie)11(w\))]TJ 0 0 0 1 k /GS1 gs 14 0 0 14 70.8661 307.26 Tm [(Ser)31(gey\022)-23.3(V)62.1(.\022)-23.3(K)40.9(ost)-19.9(y)10(uk)11(e)11(vich, Igor\022)-23.2(G.\022)-23.3(Bak)11(ulin)]TJ 10 0 0 10 70.8661 289.5907 Tm [(Mechnik)11.1(ov Nor)-20(th-W)30(est State Medical Univ)12(er)20(sit)-19.9(y \(Kir)20(ochnay)21(a\022)-23.2(st., 4)103(1)69(, St. P)10(eter)20.1(sbur)31(g, 1)138(9)125(1)75(0)87(1)113(5, Russia\))]TJ /T1_0 1 Tf 0.104 Tw 9 0 0 9 119.0551 271.0868 Tm [(Inf)-22(lammator)-42.9(y )0.5(bow)12(el )0.6(diseases )0.5(\(IBD\) )0.6(include )0.5(Crohn)24(\242)37(s )0.5(disease )0.6(and )0.5(ulcerativ)13(e )0.5(colitis. )0.5(IBDs )0.5(are )0.5(chronic )0.5(diseases )0.5(with )]TJ 0.094 Tw 0 -1.111 TD [(a tra)10(jector)-42.9(y of remission and relapse. Drug therap)12(y for IBD is no)13(t ef)-40(fectiv)13(e enough. There is a need for adjuv)16(ant )]TJ 0.02 Tw T* [(therap)12(y for IBD. The pur)-18(pose of this revie)10(w w)13(as to p)46(resent the role of e)-15(x)10(ercise and its im)16(pact on IBD. In this reg)12(ard, )]TJ 0.057 Tw T* [(a )0.6(search )0.6(is )0.5(under)-31.9(w)13(ay )0.6(for )0.6(additional )0.6(tools )0.6(to )0.6(increase )0.6(the )0.6(freq)14(uency )0.6(of )0.6(achieving )0.5(and )0.5(maintaining )0.6(remission. )0.6(There )]TJ 0.174 Tw T* [(is recent evidence that )0.5(e)-15(x)10(ercise )0.5(induces a cascade )0.5(of anti-inf)-21.9(lammator)-43(y cytokines, specif)-43(ically )0.5(tr)-36.9(igg)12(ered by an )]TJ 0.035 Tw T* [(e)-15(xponential increase in muscle interleukin 6, and with regular e)-15(x)10(ercise dur)-37(ing remission may reduce basal lev)13(els of )]TJ -0.029 Tw T* [(circulating inf)-21.9(lammator)-43(y mark)17(ers and po)13(tentially reduce chronic inf)-21.9(lammation in IBD. Doctor\242)36.9(s recommend)26(ations for )]TJ 0.023 Tw T* [(ph)12(ysical activity dur)-36.9(ing remission can be ef)-39.9(fectiv)13(e as an additional com)16(ponent of anti-relapse treatment.)]TJ /T1_2 1 Tf 0.01 Tc -0.01 Tw 8 0 0 8 70.9061 185.8175 Tm [(KEYW)22(ORDS:)]TJ /T1_0 1 Tf 0 Tc 0.023 Tw 4.948 0 Td [( inf)-22(lammator)-42.9(y bow)12(el disease, Crohn)24(\242)37(s disease, ulcerativ)13(e colitis, e)-15(x)10(ercise, adjuv)16(ant therap)12(y)]TJ /T1_2 1 Tf 0.01 Tc 0.018 Tw -4.948 -1.909 Td [(C)19(ONFL)-33(ICT)5( OF)5( INTE)25(REST)62(:)]TJ /T1_0 1 Tf 0 Tc 0.023 Tw 9.871 0 Td [( The authors declare no conf)-22(lict of interest)]TJ /T1_2 1 Tf 0.01 Tc -0.01 Tw -9.871 -1.909 Td [(FIN)16(A)31(N)23(CIN)23(G:)]TJ /T1_0 1 Tf 0 Tc 0.023 Tw 4.966 0 Td ( The study had no sponsorship.)Tj /T1_2 1 Tf 0.037 Tc 0.086 Tw -4.966 -2.617 Td [(F)3.2(O)-4.6(R)8.7( C)-17.4(I)-15.6(T)45.4(A)37.5(T)-24.5(I)-1.2(ON:)]TJ /T1_3 1 Tf 0.023 Tc 0.095 Tw 6.53 0 Td [( K)-11.2(o)-15.8(s)-29.3(t)-50.9(y)-21.5(u)-9.6(k)-6.1(e)-15.8(v)-51.8(i)-5(c)-10.2(h)]TJ /Span<>> BDC ( )Tj EMC [(S)-9.6(.)40.6(V)39.7(.)-23.5(, B)-16.4(a)-11.2(k)-14.8(u)-8.4(l)-16.7(i)-3.2(n)]TJ /Span<>> BDC ( )Tj EMC [(I)-10.3(.)15(G)-11.6(. P)-6.5(h)-14.9(y)-28.9(s)-26.1(i)-5(c)-21.5(a)-11.4(l e)-33.1(x)-9.7(e)-12.1(r)-11.7(c)-38.2(i)-7.4(s)-22.9(e)-22.7(s a)-26.7(s a)-7.6(n e)-18.6(f)-62.4(f)-28.5(e)-19.1(c)-41.5(t)-46.2(i)-14.5(v)-18.7(e a)-13(d)-16.3(j)-3.5(u)-14.9(v)-28.4(a)-7.6(n)-17.3(t t)-26.1(h)-15.1(e)-12.1(r)-30.8(a)-8.8(p)-19.6(y o)-12.1(f I)-2.4(B)0.8(D i)-3.2(n r)-19.1(e)-11.5(m)-14.5(i)-7.4(s)-22.3(s)-26.1(i)-6.8(o)-9.2(n \()39.2(r)-19.1(e)-15.8(v)-51.7(i)-11(e)-12.5(w)19.6(\))10.4(.)23( )]TJ /T1_0 1 Tf 0.033 Tc -0.033 Tw -6.535 -1.2 Td [(K)13.9(ol)3.6(op)2.4(r)3.1(o)3.4(k)-19.2(t)2.2(ol)3.6(o)-3.3(g)-13.2(i)6.7(a)5.8(.)]TJ /T1_3 1 Tf 0.013 Tc 0.034 Tw 7.019 0 Td [( 2)-18.9(0)-13.8(2)-1.2(4;2)-20.3(3)-4(\()27.7(1)34.3(\))4.6(:)10.9(1)-9.1(5)-5.3(2\226)40.8(1)2.6(6)25.9(1)-5.8(.)-10.3( \()-10.9(i)-13.2(n)-10.3( R)-16.5(u)-31.9(s)-32.2(s)-25.5(.)33.2(\).)-10.3( h)-27.2(t)-59.4(t)-39.4(p)-28.7(s)-17.9(:)-8.1(/)74.7(/)26.4(d)-21.1(o)-22.5(i)-10.2(.)-7.3(o)-21.8(r)-26.7(g)-32.8(/)1.2(1)4(0)-3.5(.)-15.6(3)-2.1(3)-25.8(8)-8.7(7)-5.4(8)-10(/)-2.1(2)-18.9(0)-0.7(7)-11.9(3)-23.3(-)31.2(7)0.7(5)-9.6(5)-18.9(6)-36.7(-2)-18.9(0)-13.8(2)-1.2(4)-38.5(-2)-20.3(3)-23.3(-)45.1(1)17(-)45.1(1)-9.1(5)-5.3(2)2.1(-)45.1(1)2.6(6)25.9(1)]TJ /T1_2 1 Tf 0.01 Tc 0.042 Tw -7.014 -2.617 Td [(\026\020\021\033\030)5( \020\036\017)5( \013\033\021\033\013\023\030\037\023:)]TJ /T1_0 1 Tf 0 Tc 0.047 Tw 10.624 0 Td ( \222\n\t\024\007\013\031\027\025\006 \207\031\032\202\031\017 \216\023\026\ \030\025\003\025\032\n\027\025\006, \225\210\213\255\214 \216\255 \253\207\ \031\027\031\032\n-\221\026\033\026\030\021\020\017 \202\n\t\205\030\026\ \032\t\024\027\031\021\021\020\017 \003\031\030\025\203\025\021\t\013\025\ \017 \205\021\025\027\031\032\t\025\024\031\024 )Tj 0.023 Tw -10.629 -1.2 Td (\025\003\031\021\025 \215.\215.)Tj /Span<>> BDC ( )Tj EMC (\240\031\006\021\025\013\n\027\026\273, \025\t\013\026\032\031\027\t\013\ \025\017 \033\032., \030.)Tj /Span<>> BDC ( )Tj EMC (47, \207\026\021\013\024-\031\024\031\032\005\205\032\202, 195067, \212\ \n\t\t\025\002; e-mail: S.Kostyukevich@szgmu.ru)Tj /T1_2 1 Tf 0.01 Tc 0.19 Tw 0.005 -1.2 Td [(ADDRESS)4.9( F)13(OR)5( C)19(ORRESPONDEN)23(CE:)]TJ /T1_0 1 Tf 0 Tc 0.195 Tw 14.395 0 Td [( K)17.9(ostyuk)17.1(evich Serg)12(ey Vladimirovich, N)17(or)-40(th-W)30.1(ester)-14(n S)28(tate Medical U)22(niv)13(ersity named af)-45.9(ter I.I.)]TJ /Span<>> BDC ( )Tj EMC [(Mechnik)13(ov)63(, )]TJ ET 1 0.68 0 0.12 k /GS0 gs q 1 0 0 1 70.8661 589.1533 cm 0 0 m 0 0 l 0 -11.339 l 42.52 -11.339 l 42.52 0 l h f Q BT 0 0 0 0 k /T1_2 1 Tf 0 Tw 9 0 0 9 76.0071 580.226 Tm (\021\033\r\035\f\033)Tj ET 1 0.68 0 0.12 k q 1 0 0 1 70.8661 279.5908 cm 0 0 m 0 0 l 0 -11.339 l 42.52 -11.339 l 42.52 0 l h f Q BT 0 0 0 0 k /T1_2 1 Tf 9 0 0 9 73.5728 270.6635 Tm (ABSTRACT)Tj 1 0.68 0 0.12 k /T1_1 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\214)10(\211\036\033 \035\030\032\t\033)30(\b)42(\032)-21(\240\033\233)]TJ 57.136 0 Td (REVIEW)Tj -57.136 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 23, \023\0221)69(, 202)69(4)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 23, \023\0221)69(, 202)69(4)]TJ /T1_4 1 Tf 25 0 0 25 20.7153 56.0378 Tm (152)Tj ET q 0 g 0 G 0 j 0 J /Fm1 Do Q 0 0 0 0 k 396.85 725.67 59.155 11.338 re f /PlacedPDF /MC0 BDC q 397.481 736.808 m 397.242 736.808 397.049 736.616 397.049 736.376 c 397.049 736.376 l 397.049 726.285 l 397.049 726.045 397.242 725.853 397.481 725.853 c 397.481 725.853 l 455.382 725.853 l 455.62 725.853 455.815 726.045 455.815 726.285 c 455.815 726.285 l 455.815 736.376 l 455.815 736.616 455.62 736.808 455.382 736.808 c 455.382 736.808 l h W n q 0 g -0.0000005 -10.9560913 -10.9560913 0.0000005 426.4320445 736.8086309 cm BX /Sh0 sh EX Q Q q 396.85 725.67 59.155 11.337 re W n 0 0 0 0.84 k q 1 0 0 1 413.5634 732.4249 cm 0 0 m -0.025 0.1 -0.063 0.196 -0.112 0.287 c -0.157 0.374 -0.218 0.451 -0.292 0.515 c -0.37 0.582 -0.46 0.632 -0.558 0.664 c -0.669 0.701 -0.786 0.719 -0.903 0.717 c -1.076 0.722 -1.247 0.681 -1.4 0.6 c -1.536 0.526 -1.652 0.42 -1.74 0.292 c -1.83 0.158 -1.895 0.008 -1.934 -0.149 c -2.018 -0.48 -2.018 -0.827 -1.934 -1.158 c -1.896 -1.316 -1.83 -1.466 -1.74 -1.602 c -1.653 -1.731 -1.536 -1.837 -1.4 -1.912 c -1.247 -1.993 -1.076 -2.033 -0.903 -2.029 c -0.774 -2.032 -0.647 -2.006 -0.528 -1.955 c -0.427 -1.906 -0.337 -1.837 -0.263 -1.753 c -0.185 -1.665 -0.124 -1.563 -0.082 -1.453 c -0.034 -1.338 0 -1.218 0.019 -1.094 c 0.635 -1.094 l 0.624 -1.297 0.578 -1.497 0.497 -1.684 c 0.421 -1.857 0.312 -2.015 0.175 -2.146 c 0.039 -2.277 -0.123 -2.379 -0.3 -2.446 c -0.492 -2.519 -0.695 -2.555 -0.9 -2.552 c -1.15 -2.557 -1.397 -2.506 -1.625 -2.404 c -1.829 -2.307 -2.01 -2.169 -2.157 -1.997 c -2.308 -1.821 -2.423 -1.617 -2.497 -1.397 c -2.655 -0.924 -2.655 -0.412 -2.497 0.061 c -2.423 0.281 -2.307 0.485 -2.157 0.661 c -2.01 0.833 -1.829 0.973 -1.625 1.07 c -1.398 1.174 -1.15 1.226 -0.9 1.222 c -0.707 1.223 -0.515 1.196 -0.329 1.14 c -0.159 1.088 0.001 1.006 0.144 0.898 c 0.278 0.793 0.39 0.662 0.473 0.513 c 0.562 0.349 0.615 0.167 0.629 -0.019 c 0 -0.019 l 0 0 l f Q q 1 0 0 1 414.6923 733.5723 cm 0 0 m 0.584 0 l 0.584 -1.328 l 0.662 -1.204 0.771 -1.103 0.9 -1.033 c 1.046 -0.951 1.213 -0.91 1.381 -0.914 c 1.627 -0.9 1.869 -0.979 2.058 -1.137 c 2.234 -1.312 2.325 -1.556 2.305 -1.803 c 2.305 -3.596 l 1.716 -3.596 l 1.716 -1.976 l 1.724 -1.817 1.678 -1.66 1.585 -1.53 c 1.486 -1.43 1.347 -1.379 1.206 -1.392 c 1.114 -1.39 1.024 -1.408 0.94 -1.445 c 0.865 -1.479 0.798 -1.529 0.744 -1.591 c 0.687 -1.656 0.645 -1.73 0.616 -1.812 c 0.586 -1.896 0.571 -1.986 0.571 -2.077 c 0.571 -3.615 l 0 -3.615 l 0 0 l f Q q 1 0 0 1 418.0385 731.1235 cm 0 0 m 0 -0.099 0.014 -0.198 0.043 -0.292 c 0.069 -0.382 0.112 -0.466 0.17 -0.54 c 0.229 -0.611 0.304 -0.669 0.388 -0.709 c 0.486 -0.754 0.594 -0.776 0.702 -0.773 c 0.845 -0.78 0.987 -0.742 1.108 -0.664 c 1.217 -0.582 1.296 -0.468 1.336 -0.337 c 1.881 -0.337 l 1.827 -0.603 1.675 -0.838 1.456 -0.996 c 1.35 -1.073 1.231 -1.131 1.105 -1.169 c 0.971 -1.208 0.831 -1.229 0.691 -1.227 c 0.509 -1.227 0.328 -1.191 0.16 -1.121 c 0.007 -1.063 -0.13 -0.972 -0.244 -0.855 c -0.356 -0.73 -0.44 -0.583 -0.491 -0.422 c -0.548 -0.243 -0.576 -0.056 -0.574 0.133 c -0.575 0.313 -0.545 0.493 -0.486 0.664 c -0.426 0.826 -0.335 0.974 -0.22 1.102 c 0.004 1.375 0.338 1.534 0.691 1.535 c 0.883 1.539 1.072 1.495 1.243 1.408 c 1.402 1.326 1.541 1.209 1.649 1.067 c 1.759 0.922 1.838 0.757 1.883 0.582 c 1.932 0.396 1.945 0.203 1.92 0.013 c 0 0.013 l 0 0 l 1.342 0.377 m 1.335 0.468 1.315 0.557 1.283 0.643 c 1.253 0.724 1.209 0.798 1.153 0.863 c 1.097 0.922 1.03 0.97 0.957 1.004 c 0.874 1.043 0.783 1.063 0.691 1.062 c 0.6 1.062 0.509 1.044 0.425 1.009 c 0.345 0.976 0.273 0.926 0.213 0.863 c 0.153 0.799 0.105 0.724 0.072 0.643 c 0.037 0.559 0.017 0.468 0.014 0.377 c 1.355 0.377 l h f Q q 1 0 0 1 422.1581 731.7051 cm 0 0 m -0.012 0.144 -0.082 0.276 -0.194 0.366 c -0.31 0.452 -0.451 0.495 -0.595 0.489 c -0.675 0.488 -0.755 0.476 -0.831 0.452 c -0.918 0.424 -0.998 0.375 -1.062 0.311 c -1.142 0.229 -1.202 0.131 -1.24 0.024 c -1.29 -0.132 -1.312 -0.296 -1.304 -0.459 c -1.304 -0.569 -1.292 -0.677 -1.267 -0.784 c -1.244 -0.885 -1.202 -0.983 -1.145 -1.07 c -1.09 -1.154 -1.016 -1.224 -0.93 -1.275 c -0.833 -1.33 -0.722 -1.356 -0.611 -1.352 c -0.457 -1.357 -0.307 -1.301 -0.194 -1.195 c -0.078 -1.077 -0.005 -0.922 0.011 -0.757 c 0.587 -0.757 l 0.556 -1.055 0.419 -1.332 0.202 -1.538 c -0.022 -1.721 -0.306 -1.815 -0.595 -1.803 c -0.777 -1.806 -0.958 -1.771 -1.126 -1.7 c -1.293 -1.642 -1.445 -1.547 -1.57 -1.421 c -1.68 -1.297 -1.763 -1.151 -1.814 -0.993 c -1.87 -0.822 -1.898 -0.643 -1.896 -0.462 c -1.898 -0.276 -1.871 -0.091 -1.817 0.087 c -1.766 0.252 -1.682 0.405 -1.57 0.537 c -1.459 0.664 -1.323 0.766 -1.168 0.834 c -0.991 0.914 -0.798 0.955 -0.603 0.954 c -0.457 0.954 -0.311 0.935 -0.17 0.895 c -0.039 0.858 0.084 0.799 0.194 0.72 c 0.302 0.643 0.393 0.543 0.459 0.428 c 0.531 0.298 0.572 0.155 0.582 0.008 c 0 0.008 l 0 0 l f Q q 1 0 0 1 423.2177 733.5723 cm 0 0 m 0.577 0 l 0.577 -2.048 l 1.615 -0.985 l 2.322 -0.985 l 1.323 -1.944 l 2.417 -3.604 l 1.716 -3.604 l 0.919 -2.337 l 0.577 -2.669 l 0.577 -3.604 l 0 -3.604 l h f Q q 1 0 0 1 427.0585 732.5762 cm 0 0 m 0.436 0 l 0.436 0.218 l 0.429 0.352 0.448 0.486 0.488 0.614 c 0.521 0.705 0.577 0.786 0.651 0.85 c 0.717 0.905 0.795 0.943 0.879 0.961 c 0.966 0.979 1.056 0.988 1.145 0.988 c 1.28 0.993 1.416 0.981 1.548 0.954 c 1.548 0.505 l 1.509 0.516 1.469 0.523 1.429 0.528 c 1.379 0.532 1.33 0.532 1.28 0.528 c 1.209 0.53 1.14 0.511 1.081 0.473 c 1.019 0.419 0.987 0.337 0.999 0.255 c 0.999 -0.011 l 1.498 -0.011 l 1.498 -0.441 l 1.009 -0.441 l 1.009 -2.622 l 0.436 -2.622 l 0.436 -0.428 l 0.005 -0.428 l 0.005 0 l 0 0 l f Q q 1 0 0 1 430.1 729.8965 cm 0 0 m -0.191 -0.003 -0.381 0.032 -0.559 0.104 c -0.715 0.167 -0.856 0.264 -0.972 0.388 c -1.091 0.512 -1.181 0.659 -1.238 0.82 c -1.356 1.18 -1.356 1.567 -1.238 1.925 c -1.181 2.087 -1.091 2.234 -0.972 2.358 c -0.856 2.481 -0.715 2.578 -0.559 2.643 c -0.199 2.78 0.198 2.78 0.558 2.643 c 0.714 2.578 0.855 2.481 0.972 2.358 c 1.09 2.234 1.181 2.087 1.237 1.925 c 1.355 1.567 1.355 1.18 1.237 0.82 c 1.181 0.659 1.09 0.512 0.972 0.388 c 0.855 0.266 0.713 0.169 0.558 0.106 c 0.38 0.034 0.191 -0.002 0 0 c 0 0.454 m 0.115 0.451 0.23 0.479 0.332 0.534 c 0.424 0.586 0.502 0.659 0.562 0.746 c 0.624 0.836 0.669 0.936 0.695 1.041 c 0.752 1.26 0.752 1.491 0.695 1.71 c 0.669 1.816 0.625 1.916 0.562 2.005 c 0.502 2.091 0.423 2.163 0.332 2.215 c 0.123 2.323 -0.126 2.323 -0.335 2.215 c -0.427 2.163 -0.505 2.091 -0.566 2.005 c -0.628 1.916 -0.673 1.816 -0.699 1.71 c -0.756 1.491 -0.756 1.26 -0.699 1.041 c -0.672 0.936 -0.627 0.836 -0.566 0.746 c -0.506 0.659 -0.427 0.586 -0.335 0.534 c -0.232 0.478 -0.117 0.451 0 0.454 c f Q q 1 0 0 1 431.8979 732.5762 cm 0 0 m 0.531 0 l 0.531 -0.505 l 0.55 -0.43 0.583 -0.359 0.629 -0.297 c 0.681 -0.229 0.74 -0.167 0.807 -0.114 c 0.877 -0.059 0.956 -0.014 1.039 0.019 c 1.123 0.053 1.213 0.07 1.304 0.069 c 1.52 0.069 l 1.52 -0.486 l 1.395 -0.467 l 1.269 -0.467 l 1.178 -0.468 1.087 -0.488 1.004 -0.526 c 0.917 -0.565 0.839 -0.625 0.778 -0.699 c 0.716 -0.783 0.669 -0.878 0.643 -0.98 c 0.604 -1.104 0.584 -1.233 0.586 -1.362 c 0.586 -2.603 l 0.01 -2.603 l 0.01 0 l 0 0 l f Q q 1 0 0 1 437.3666 729.9683 cm 0 0 m -0.577 0 l -0.577 0.364 l -0.649 0.23 -0.759 0.121 -0.893 0.047 c -1.022 -0.029 -1.169 -0.07 -1.32 -0.072 c -1.595 -0.095 -1.866 0.002 -2.064 0.194 c -2.234 0.413 -2.316 0.687 -2.295 0.964 c -2.295 2.608 l -1.719 2.608 l -1.719 1.014 l -1.735 0.843 -1.689 0.67 -1.588 0.531 c -1.492 0.433 -1.357 0.382 -1.219 0.39 c -1.116 0.387 -1.012 0.406 -0.917 0.446 c -0.84 0.479 -0.772 0.531 -0.72 0.595 c -0.667 0.661 -0.63 0.738 -0.611 0.82 c -0.588 0.911 -0.577 1.003 -0.577 1.097 c -0.577 2.611 l 0 2.611 l 0 0 l f Q q 1 0 0 1 437.9877 732.5762 cm 0 0 m 0.545 0 l 0.545 -0.353 l 0.617 -0.209 0.736 -0.094 0.882 -0.026 c 1.03 0.04 1.19 0.073 1.352 0.072 c 1.535 0.075 1.717 0.038 1.883 -0.037 c 2.031 -0.106 2.161 -0.208 2.263 -0.334 c 2.366 -0.465 2.442 -0.615 2.489 -0.775 c 2.54 -0.948 2.566 -1.127 2.566 -1.307 c 2.566 -1.479 2.542 -1.651 2.497 -1.817 c 2.455 -1.973 2.385 -2.121 2.29 -2.252 c 2.099 -2.522 1.789 -2.682 1.458 -2.68 c 1.369 -2.681 1.28 -2.674 1.193 -2.659 c 1.11 -2.644 1.028 -2.618 0.951 -2.584 c 0.875 -2.552 0.802 -2.509 0.736 -2.457 c 0.671 -2.406 0.615 -2.343 0.571 -2.273 c 0.571 -3.575 l -0.005 -3.575 l -0.005 0 l 0 0 l 2.008 -1.307 m 2.008 -1.191 1.993 -1.076 1.963 -0.964 c 1.936 -0.859 1.89 -0.759 1.828 -0.669 c 1.768 -0.584 1.69 -0.514 1.599 -0.462 c 1.503 -0.409 1.395 -0.382 1.286 -0.385 c 1.072 -0.372 0.867 -0.467 0.738 -0.638 c 0.607 -0.836 0.543 -1.072 0.555 -1.31 c 0.554 -1.433 0.57 -1.557 0.603 -1.676 c 0.631 -1.781 0.68 -1.879 0.747 -1.965 c 0.809 -2.044 0.886 -2.109 0.975 -2.157 c 1.071 -2.206 1.178 -2.23 1.286 -2.229 c 1.401 -2.232 1.517 -2.205 1.618 -2.148 c 1.708 -2.096 1.785 -2.025 1.843 -1.939 c 1.903 -1.85 1.945 -1.751 1.968 -1.646 c 1.995 -1.535 2.008 -1.421 2.008 -1.307 c f Q q 1 0 0 1 443.5127 729.9683 cm 0 0 m -0.545 0 l -0.545 0.353 l -0.616 0.211 -0.734 0.099 -0.879 0.034 c -1.027 -0.031 -1.187 -0.065 -1.349 -0.064 c -1.532 -0.067 -1.714 -0.03 -1.88 0.045 c -2.028 0.113 -2.158 0.214 -2.26 0.34 c -2.364 0.47 -2.441 0.62 -2.486 0.781 c -2.538 0.958 -2.564 1.143 -2.563 1.328 c -2.568 1.536 -2.536 1.742 -2.468 1.938 c -2.41 2.097 -2.319 2.242 -2.202 2.364 c -2.101 2.471 -1.977 2.555 -1.838 2.608 c -1.705 2.659 -1.563 2.685 -1.421 2.685 c -1.338 2.685 -1.256 2.678 -1.174 2.664 c -1.091 2.648 -1.01 2.624 -0.932 2.589 c -0.855 2.556 -0.783 2.514 -0.717 2.462 c -0.652 2.411 -0.597 2.349 -0.553 2.279 c -0.553 3.606 l 0.024 3.606 l 0.024 0 l 0 0 l -2.008 1.277 m -2.009 1.166 -1.994 1.056 -1.965 0.948 c -1.939 0.845 -1.896 0.748 -1.835 0.661 c -1.777 0.578 -1.699 0.508 -1.61 0.459 c -1.404 0.355 -1.162 0.355 -0.956 0.459 c -0.866 0.512 -0.789 0.585 -0.73 0.671 c -0.671 0.762 -0.626 0.862 -0.6 0.966 c -0.572 1.076 -0.558 1.188 -0.558 1.301 c -0.543 1.542 -0.612 1.781 -0.751 1.979 c -0.88 2.14 -1.078 2.229 -1.283 2.22 c -1.402 2.224 -1.52 2.196 -1.623 2.138 c -1.714 2.083 -1.793 2.009 -1.852 1.92 c -1.911 1.828 -1.954 1.725 -1.977 1.617 c -1.999 1.505 -2.01 1.392 -2.008 1.277 c f Q q 1 0 0 1 446.3252 730.5499 cm 0 0 m -0.004 -0.052 0.005 -0.104 0.026 -0.151 c 0.052 -0.185 0.094 -0.202 0.136 -0.197 c 0.197 -0.197 l 0.223 -0.2 0.25 -0.2 0.276 -0.197 c 0.276 -0.595 l 0.199 -0.619 l 0.101 -0.64 l 0 -0.656 l -0.085 -0.656 l -0.187 -0.66 -0.288 -0.635 -0.377 -0.584 c -0.461 -0.528 -0.516 -0.437 -0.528 -0.337 c -0.648 -0.451 -0.792 -0.534 -0.951 -0.579 c -1.106 -0.628 -1.269 -0.654 -1.432 -0.656 c -1.546 -0.657 -1.659 -0.641 -1.769 -0.608 c -1.872 -0.579 -1.967 -0.531 -2.053 -0.468 c -2.136 -0.405 -2.203 -0.324 -2.25 -0.231 c -2.3 -0.127 -2.326 -0.012 -2.324 0.104 c -2.33 0.24 -2.299 0.375 -2.236 0.497 c -2.181 0.594 -2.101 0.675 -2.005 0.733 c -1.905 0.791 -1.795 0.833 -1.681 0.855 c -1.562 0.88 -1.442 0.899 -1.32 0.914 c -1.222 0.933 -1.123 0.947 -1.022 0.956 c -0.938 0.963 -0.855 0.977 -0.773 0.999 c -0.708 1.014 -0.649 1.046 -0.6 1.092 c -0.556 1.144 -0.533 1.211 -0.536 1.28 c -0.534 1.344 -0.553 1.408 -0.59 1.46 c -0.624 1.507 -0.668 1.544 -0.72 1.569 c -0.775 1.596 -0.834 1.613 -0.895 1.62 c -0.955 1.624 -1.016 1.624 -1.076 1.62 c -1.215 1.625 -1.354 1.591 -1.474 1.519 c -1.581 1.45 -1.647 1.333 -1.652 1.206 c -2.231 1.206 l -2.227 1.354 -2.185 1.498 -2.108 1.625 c -2.041 1.733 -1.951 1.824 -1.843 1.891 c -1.729 1.96 -1.603 2.007 -1.472 2.032 c -1.329 2.072 -1.183 2.098 -1.036 2.109 c -0.908 2.109 -0.781 2.096 -0.656 2.069 c -0.538 2.044 -0.425 2 -0.321 1.939 c -0.225 1.88 -0.143 1.8 -0.083 1.705 c -0.02 1.599 0.012 1.478 0.008 1.354 c 0.008 0.013 l 0 0 l -0.576 0.728 m -0.674 0.667 -0.785 0.631 -0.9 0.624 c -1.028 0.612 -1.155 0.594 -1.283 0.571 c -1.343 0.561 -1.402 0.547 -1.46 0.528 c -1.515 0.511 -1.566 0.485 -1.612 0.451 c -1.657 0.419 -1.692 0.376 -1.716 0.327 c -1.742 0.267 -1.755 0.203 -1.753 0.138 c -1.755 0.079 -1.735 0.021 -1.697 -0.024 c -1.661 -0.067 -1.615 -0.103 -1.564 -0.127 c -1.509 -0.154 -1.451 -0.171 -1.392 -0.181 c -1.335 -0.19 -1.278 -0.196 -1.222 -0.197 c -1.152 -0.196 -1.083 -0.188 -1.015 -0.173 c -0.94 -0.156 -0.87 -0.127 -0.805 -0.088 c -0.74 -0.048 -0.684 0.004 -0.64 0.066 c -0.594 0.134 -0.571 0.215 -0.574 0.297 c -0.574 0.725 l h f Q q 1 0 0 1 446.6836 732.5762 cm 0 0 m 0.434 0 l 0.434 0.784 l 0.996 0.784 l 0.996 0 l 1.527 0 l 1.527 -0.43 l 0.996 -0.43 l 0.996 -1.822 l 0.993 -1.874 0.993 -1.927 0.996 -1.979 c 1 -2.018 1.011 -2.056 1.031 -2.09 c 1.05 -2.122 1.079 -2.146 1.113 -2.159 c 1.162 -2.177 1.213 -2.185 1.265 -2.183 c 1.387 -2.183 l 1.428 -2.181 1.469 -2.175 1.509 -2.165 c 1.509 -2.608 l 1.323 -2.629 l 1.261 -2.633 1.199 -2.633 1.137 -2.629 c 1.013 -2.633 0.89 -2.619 0.771 -2.587 c 0.688 -2.564 0.613 -2.52 0.553 -2.459 c 0.499 -2.4 0.462 -2.328 0.446 -2.25 c 0.427 -2.155 0.416 -2.059 0.415 -1.963 c 0.415 -0.428 l -0.019 -0.428 l -0.019 0 l 0 0 l f Q q 1 0 0 1 449.0742 731.1235 cm 0 0 m 0 -0.099 0.014 -0.198 0.042 -0.292 c 0.068 -0.382 0.112 -0.466 0.17 -0.54 c 0.229 -0.611 0.303 -0.669 0.388 -0.709 c 0.486 -0.754 0.593 -0.776 0.701 -0.773 c 0.845 -0.78 0.987 -0.742 1.107 -0.664 c 1.216 -0.582 1.296 -0.468 1.336 -0.337 c 1.88 -0.337 l 1.827 -0.603 1.674 -0.838 1.456 -0.996 c 1.349 -1.073 1.231 -1.131 1.105 -1.169 c 0.973 -1.208 0.836 -1.228 0.699 -1.227 c 0.512 -1.23 0.327 -1.196 0.154 -1.126 c 0.003 -1.066 -0.133 -0.973 -0.244 -0.855 c -0.356 -0.73 -0.44 -0.583 -0.491 -0.422 c -0.548 -0.243 -0.576 -0.056 -0.574 0.133 c -0.575 0.313 -0.546 0.493 -0.486 0.664 c -0.426 0.826 -0.336 0.974 -0.221 1.102 c 0.002 1.374 0.334 1.532 0.685 1.535 c 0.877 1.539 1.067 1.495 1.238 1.408 c 1.396 1.326 1.535 1.209 1.644 1.067 c 1.753 0.922 1.833 0.757 1.878 0.582 c 1.927 0.396 1.939 0.203 1.915 0.013 c -0.002 0.013 l 0 0 l 1.341 0.377 m 1.335 0.468 1.315 0.557 1.283 0.643 c 1.253 0.724 1.209 0.798 1.153 0.863 c 1.096 0.926 1.027 0.978 0.951 1.014 c 0.868 1.054 0.777 1.074 0.685 1.073 c 0.594 1.073 0.504 1.055 0.419 1.02 c 0.339 0.986 0.267 0.937 0.207 0.874 c 0.147 0.81 0.099 0.735 0.066 0.653 c 0.031 0.569 0.011 0.479 0.008 0.388 c 1.349 0.388 l h f Q q 1 0 0 1 451.8657 730.7994 cm 0 0 m 0.002 -0.142 0.073 -0.274 0.191 -0.353 c 0.312 -0.423 0.45 -0.458 0.59 -0.454 c 0.651 -0.458 0.711 -0.458 0.773 -0.454 c 0.839 -0.447 0.904 -0.43 0.967 -0.406 c 1.024 -0.385 1.075 -0.349 1.116 -0.303 c 1.155 -0.252 1.174 -0.189 1.168 -0.125 c 1.166 -0.057 1.138 0.008 1.089 0.056 c 1.033 0.107 0.967 0.146 0.895 0.17 c 0.809 0.201 0.72 0.226 0.629 0.245 c 0.329 0.33 l 0.224 0.352 0.121 0.38 0.019 0.415 c -0.076 0.446 -0.166 0.491 -0.247 0.55 c -0.327 0.608 -0.391 0.683 -0.436 0.771 c -0.486 0.873 -0.511 0.986 -0.507 1.1 c -0.512 1.226 -0.475 1.351 -0.404 1.456 c -0.333 1.551 -0.243 1.63 -0.138 1.687 c -0.028 1.747 0.092 1.788 0.215 1.809 c 0.337 1.832 0.462 1.843 0.587 1.843 c 0.716 1.844 0.845 1.83 0.972 1.801 c 1.09 1.774 1.202 1.727 1.304 1.663 c 1.404 1.598 1.488 1.513 1.551 1.413 c 1.621 1.3 1.663 1.173 1.676 1.041 c 1.076 1.041 l 1.059 1.155 0.989 1.253 0.887 1.307 c 0.78 1.355 0.665 1.38 0.547 1.378 c 0.5 1.381 0.452 1.381 0.403 1.378 c 0.35 1.373 0.298 1.36 0.247 1.341 c 0.2 1.325 0.157 1.297 0.122 1.262 c 0.087 1.224 0.069 1.174 0.071 1.124 c 0.069 1.058 0.096 0.995 0.146 0.951 c 0.202 0.903 0.267 0.866 0.337 0.842 c 0.424 0.811 0.512 0.786 0.603 0.768 c 0.917 0.701 l 1.021 0.678 1.124 0.65 1.224 0.616 c 1.319 0.584 1.409 0.539 1.49 0.481 c 1.662 0.359 1.762 0.16 1.755 -0.05 c 1.76 -0.189 1.723 -0.326 1.649 -0.443 c 1.582 -0.551 1.491 -0.642 1.384 -0.709 c 1.267 -0.778 1.14 -0.827 1.007 -0.855 c 0.873 -0.885 0.735 -0.9 0.598 -0.9 c 0.443 -0.902 0.29 -0.883 0.141 -0.845 c 0.01 -0.812 -0.114 -0.753 -0.223 -0.674 c -0.324 -0.601 -0.407 -0.504 -0.465 -0.393 c -0.527 -0.269 -0.559 -0.131 -0.558 0.008 c 0.019 0.008 l 0 0 l f Q 0.146 0.941 0.992 0.044 k q 1 0 0 1 401.2527 729.3892 cm 0 0 m 3.612 2.406 l 3.612 5.296 l 0 5.296 l h f Q 0 0.889 0.676 0 k q 1 0 0 1 404.865 729.3892 cm 0 0 m -3.612 2.406 l -3.612 5.296 l 0 5.296 l h f Q 0.694 0.076 0.209 0 k q 1 0 0 1 403.0589 735.3145 cm 0 0 m -2.2 0 -3.984 -1.784 -3.984 -3.984 c -3.984 -6.184 -2.2 -7.968 0 -7.968 c 2.2 -7.968 3.984 -6.184 3.984 -3.984 c 3.984 -1.784 2.2 0 0 0 c 0 -6.993 m -1.662 -6.993 -3.009 -5.646 -3.009 -3.984 c -3.009 -2.322 -1.662 -0.975 0 -0.975 c 1.662 -0.975 3.009 -2.322 3.009 -3.984 c 3.009 -5.646 1.662 -6.993 0 -6.993 c f Q 0 0.235 0.86 0 k q 1 0 0 1 405.2601 729.2803 cm 0 0 m -1.118 -1.208 -3.015 -1.281 -4.237 -0.159 c -5.159 0.688 -5.459 2.005 -4.999 3.156 c -5.833 3.687 l -6.736 1.681 -5.843 -0.679 -3.836 -1.582 c -2.218 -2.311 -0.312 -1.881 0.836 -0.528 c 0 0 l f Q 0 0 0 0.6 k q 1 0 0 1 397.4813 736.8087 cm 0 0 m -0.238 0 -0.432 -0.193 -0.432 -0.432 c -0.432 -10.524 l -0.432 -10.763 -0.238 -10.956 0 -10.956 c 57.901 -10.956 l 58.139 -10.956 58.333 -10.763 58.333 -10.524 c 58.333 -0.432 l 58.333 -0.193 58.139 0 57.901 0 c h 57.901 -11.155 m 0 -11.155 l -0.348 -11.155 -0.631 -10.872 -0.631 -10.524 c -0.631 -0.432 l -0.631 -0.084 -0.348 0.199 0 0.199 c 57.901 0.199 l 58.249 0.199 58.532 -0.084 58.532 -0.432 c 58.532 -10.524 l 58.532 -10.872 58.249 -11.155 57.901 -11.155 c f Q EMC Q endstream endobj 670 0 obj <> endobj 675 0 obj <>stream Adobe Illustrator CS6 (Windows) 2021-04-12T11:45:36+05:00 2021-06-02T10:28:09+05:00 2021-06-02T10:28:09+05:00 1 False False 20.868494 3.999928 Millimeters Cyan Magenta Yellow Black Default Swatch Group 0 C=0 M=24 Y=86 K=0 PROCESS 100.000000 CMYK 0.000000 23.504999 86.022697 0.000000 C=69 M=8 Y=21 K=0 PROCESS 100.000000 CMYK 69.369003 7.635600 20.892700 0.000000 C=0 M=89 Y=68 K=0 PROCESS 100.000000 CMYK 0.000000 88.946404 67.623398 0.000000 C=15 M=94 Y=99 K=4 PROCESS 100.000000 CMYK 14.578501 94.070297 99.160698 4.416000 C=0 M=0 Y=0 K=84 PROCESS 100.000000 CMYK 0.000000 0.000000 0.000000 84.000000 C=0 M=0 Y=0 K=35 PROCESS 100.000000 CMYK 0.000000 0.000000 0.000000 35.000000 C=0 M=0 Y=0 K=60 PROCESS 100.000000 CMYK 0.000000 0.000000 0.000000 60.000004 Document application/pdf proof:pdf xmp.did:804244B35A9BEB118A6FC3C256996E2F uuid:08e30110-bdb7-4606-97ca-63fb62cbcecc uuid:21079f76-f6d7-4329-b725-f2fb35af5114 uuid:722f8893-0b3c-4402-87fb-c713f1fa0e26 uuid:21079f76-f6d7-4329-b725-f2fb35af5114 uuid:21079f76-f6d7-4329-b725-f2fb35af5114 proof:pdf saved xmp.iid:804244B35A9BEB118A6FC3C256996E2F 2021-04-12T11:45:42+05:00 Adobe Illustrator CS6 (Windows) / endstream endobj 674 0 obj <>/Border[0 0 0]/H/N/Rect[394.85 739.008 458.005 723.67]/Subtype/Link/Type/Annot>> endobj 676 0 obj <> endobj 666 0 obj [677 0 R 678 0 R 679 0 R 680 0 R 681 0 R 682 0 R 683 0 R 684 0 R 685 0 R 686 0 R 687 0 R 688 0 R 689 0 R 690 0 R 691 0 R 692 0 R 693 0 R 694 0 R 695 0 R 696 0 R 697 0 R 698 0 R 699 0 R 700 0 R 701 0 R 702 0 R 703 0 R 704 0 R 705 0 R 706 0 R 707 0 R 708 0 R 709 0 R 710 0 R 711 0 R] endobj 667 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\021\220\001\201\002\025\024 \212\r\016\001\220\007\216\001\025\202)10(\025 \221\025\007\220\221\025)21(\222\013 \(\025\f\222\025\002 \007\220\026)11(\016\002\013\026)-20(\215\002\020\))]TJ 45.723 0 Td [(Ju)10(v)12(enile polyposis s)10(yndr)20(ome \(r)31(e)11(vie)11(w\))]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0.197 Tw 8 0 0 8 42.5197 731.2159 Tm (J Gastrointest Endosc.)Tj /T1_2 1 Tf [( 2018 Sep 16;10\(9\):210\226218. d)-15.9(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.4253/)Tj 0 -1.25 TD (wjge.v10.i9.210)Tj 0 0 0 1 k /GS1 gs 0.127 Tw T* (56.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(L)-32(i)]TJ /Span<>> BDC ( )Tj EMC [(M, Al)-30.9(i)]TJ /Span<>> BDC ( )Tj EMC [(SM, U)12(mm-a-Omar)-33(ah Gil)-15.9(ani)]TJ /Span<>> BDC ( )Tj EMC [(S, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. K)25(ud)-16(o\245s pi)-24(t p)32(a)15(t)-29.9(ter)-15(n )]TJ 0.294 Tw -1.796 -1.25 Td [(cl)-16(assif)-27.9(ica)15(t)-32(ion for col)30(or)-24(ec)-15.9(t)15(al neopl)-16(as)26(ms: a me)-12(t)15(a-anal)35.1(y)-13(sis. )]TJ /T1_1 1 Tf [(W)29(orld J )]TJ 0 Tw T* (Gastroenterol.)Tj /T1_2 1 Tf 0.003 Tw [( 2014 Sep 21;20\(35\):12649\22656. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.3748/wjg.v20.)Tj T* (i35.12649)Tj 0 0 0 1 k /GS1 gs 0.344 Tw T* (57.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Ha)15(t)-30(t)17(or)-36.9(i)]TJ /Span<>> BDC ( )Tj EMC [(S, Iw)-12(a)15(t)15(a)15(te)]TJ /Span<>> BDC ( )Tj EMC (M, Sano)Tj /Span<>> BDC ( )Tj EMC [(W, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Nar)-23.9(r)-32(o)-14(w-band ima)-17(ging )]TJ 0.103 Tw -1.796 -1.25 Td [(obser)-32(v)-15(a)15.1(t)-32(ion of col)30(or)-24(ec)-16(t)15(al lesions using NICE cl)-16(assif)-28(ica)15(t)-32(ion t)17(o avoid )]TJ 0.038 Tw T* [(discar)-24(ding signif)-28(icant lesions. )]TJ /T1_1 1 Tf [(W)29(orld J Gastrointest Endosc.)]TJ /T1_2 1 Tf ( 2014 Dec )Tj 0.023 Tw T* [(16;6\(12\):600\2265. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.4253/wjge.v6.i12.600)Tj 0 0 0 1 k /GS1 gs -0.015 Tw T* (58.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(K)25(oba)15(y)22(ashi)]TJ /Span<>> BDC ( )Tj EMC [(S, Y)50(amad)42(a)]TJ /Span<>> BDC ( )Tj EMC [(M, T)40(ak)-17(amar)-22(u)]TJ /Span<>> BDC ( )Tj EMC [(H, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Dia)-17(gnost)-32(ic yield of t)-13(he )]TJ -0.047 Tw -1.796 -1.25 Td [(Jap)32(an NBI E)35(xper)-22(t T)40(eam \(JNET\) cl)-15.9(assif)-28(ica)15(t)-32(ion for end)-16(oscopic dia)-17(gnosis )]TJ 0.064 Tw T* [(of super)-24(f)-28(ic)-24(ial col)30(or)-24(ec)-16(t)15.1(al neopl)-16(as)26.1(ms in a l)-16(ar)-32(ge-scale cl)-31(inical p)25(r)-33(a)-17(c)-16(t)-31.9(ice )]TJ 0 Tw T* [(d)42(a)15(t)15(abase. )]TJ /T1_1 1 Tf 0.066 Tw 4.12 0 Td [(U)22(nited European Gastroenterol)]TJ /Span<>> BDC ( )Tj EMC (J.)Tj /T1_2 1 Tf [( 2019 A)10(ug;7\(7\):914\226923. )]TJ 0 Tw -4.12 -1.25 Td [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1177/2050640619845987)Tj 0 0 0 1 k /GS1 gs 0.282 Tw -1.847 -1.25 Td (59.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(W)12(a)15(t)15(anabe)]TJ /Span<>> BDC ( )Tj EMC [(A, Na)-17.1(gashima)]TJ /Span<>> BDC ( )Tj EMC [(H, M)-24(o)17(t)17(oi)]TJ /Span<>> BDC ( )Tj EMC [(M, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. F)20.1(amil)-31(ial juvenile )]TJ 0.05 Tw -1.796 -1.25 Td [(pol)35(yposis of t)-12.9(he st)17(oma)-16.9(ch. )]TJ /T1_1 1 Tf 0 Tw (Gastroenterology)Tj /T1_2 1 Tf 0.05 Tw (. 1979 Jul;77\(1\):148\22651. )Tj 0.023 Tw T* (PMID: 447014.)Tj 0.01 Tc 0.356 Tw T* [(6)0.5(0)0.5(.)]TJ /Span<>> BDC 1.324 0 Td ( )Tj EMC 0.51 0 Td [(L)-31.5(a)10.5(w)0.5(l)0.5(e)0.5(s)0.5(s)]TJ /Span<>> BDC 3.129 0 Td ( )Tj EMC 0.599 0 Td [(M)0.5(E)0.5(,)0.5( )0.5(T)45.5(o)-13.5(w)0.5(e)0.5(i)0.5(l)0.5(l)]TJ /Span<>> BDC 4.852 0 Td ( )Tj EMC 0.599 0 Td [(D)0.5(L)0.5(,)0.5( )0.5(J)0.5(e)0.5(w)0.5(e)0.5(l)0.5(l)]TJ /Span<>> BDC 4.402 0 Td ( )Tj EMC 0.599 0 Td [(K)0.5(D)0.5(,)0.5( )0.5(e)-11.5(t)]TJ /Span<>> BDC 2.736 0 Td ( )Tj EMC 0.599 0 Td [(a)0.5(l)0.5(.)0.5( )0.5(M)0.5(a)0.5(s)0.5(s)0.5(i)-15.5(v)0.5(e)0.5( )0.5(G)0.5(a)0.5(s)0.5(t)0.5(r)-36.5(i)0.5(c)10( )]TJ 0.014 Tc 0.526 Tw -19.348 -1.25 Td [(Juvenile P)9.6(ol)34.7(yposis: A Cl)-31.3(inicop)31.7(a)14.6(t)-13.3(hol)29.7(o)-16.3(gic S)14.6(tud)16.7(y Using SMAD4)14( )]TJ 0 Tc 0 Tw T* [(Immunohist)17.1(o)-16(chemistr)-24(y. )]TJ /T1_1 1 Tf 0.199 Tw 10.067 0 Td [(Am J Clin P)18(athol. )]TJ /T1_2 1 Tf [(2017 Ap)25(r 1;147\(4\):390. )]TJ 0 Tw -10.067 -1.25 Td [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1093/ajcp/aqx015)Tj 0 0 0 1 k /GS1 gs 0.17 Tw -1.847 -1.25 Td (61.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Gonzalez)Tj /Span<>> BDC ( )Tj EMC [(RS, A)15(dsa)15(y)]TJ /Span<>> BDC ( )Tj EMC [(V, G)20(r)-33(aham)]TJ /Span<>> BDC ( )Tj EMC [(RP, e)-11.9(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Massi)-15.9(ve gastr)-37(ic juve)]TJ 0 Tw (-)Tj 0.004 Tc 0.35 Tw -1.796 -1.25 Td [(nile-t)-10(ype )0.5(pol)35(yposis: )0.5(a )0.5(cl)-31(inicop)32(a)15(t)-13(hol)30(o)-16(gical )0.5(anal)35(y)-13(sis )0.5(of )0.5(22 )0.5(cases.)4( )]TJ /T1_1 1 Tf 0 Tc 0 Tw T* (Histopathology)Tj /T1_2 1 Tf 0.023 Tw [(. 2017 Ma)15(y;70\(6\):918\226928. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1111/his.13149)Tj 0 0 0 1 k /GS1 gs 0.018 Tc 0.657 Tw T* (62.)Tj /Span<>> BDC ( )Tj EMC 1.868 0 Td [(Br)-32.1(onner)]TJ /Span<>> BDC ( )Tj EMC [(MP. Gastr)-32.1(ointest)-32.1(inal inher)-37.1(i)-24.1(ted pol)34.9(yposis syn)]TJ 0 Tc 0 Tw (-)Tj 0.005 Tc -0.005 Tw -1.868 -1.25 Td [(dr)-32.1(omes. )]TJ /T1_1 1 Tf 0.35 Tw 3.843 0 Td [(Mod P)17.9(athol.)]TJ /T1_2 1 Tf [( 2003 Ap)24.9(r;16\(4\):359\22665. d)-16.1(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs -0.005 Tw 18.709 0 Td (10.1097/01.)Tj 0 Tc 0 Tw -22.552 -1.25 Td (MP.0000062992.54036.E4)Tj 0 0 0 1 k /GS1 gs 0.023 Tw ( PMID: 12692201.)Tj 0.01 Tc 0.372 Tw T* (63.)Tj /Span<>> BDC ( )Tj EMC 1.836 0 Td [(L)35(eonar)-23.9(d)]TJ /Span<>> BDC ( )Tj EMC 3.881 0 Td [(NB, )0.5(Br)-31.9(onner)]TJ /Span<>> BDC ( )Tj EMC 5.861 0 Td [(MP. )0.5(Giant )0.5(Gastr)-36.9(ic )0.5(F)10(olds )0.6(in )0.5(Juvenile)10( )]TJ 0.004 Tc -0.004 Tw -11.578 -1.25 Td [(P)9.7(ol)34.7(yposis. )]TJ /T1_1 1 Tf 0.35 Tw 4.655 0 Td [(Case R)20.7(ep Gastroenterol. )]TJ /T1_2 1 Tf [(2021 Dec 23;15\(3\):985\226993.)4( )]TJ 0 Tc 0 Tw -4.655 -1.25 Td [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1159/000521125)Tj 0 0 0 1 k /GS1 gs 0.005 Tc 0.35 Tw -1.847 -1.25 Td (64.)Tj /Span<>> BDC ( )Tj EMC 1.818 0 Td (Ma)Tj /Span<>> BDC ( )Tj EMC [(C, Giar)-24.4(diell)29.7(o)]TJ /Span<>> BDC ( )Tj EMC [(FM, M)-24.4(ontgomer)-24.3(y)]TJ /Span<>> BDC ( )Tj EMC [(EA. U)12.6(pper tr)-33.4(a)-17.4(c)-16.4(t juvenile)5( )]TJ 0 Tc 0.323 Tw -1.818 -1.25 Td [(pol)35(yps in juvenile pol)35(yposis p)32(a)15(t)-32(ients: d)17(y)-13(spl)-16(asia and mal)-30.9(ignancy )]TJ 0.305 Tw T* [(ar)-24(e asso)-16(c)-24(ia)15.1(ted wi)-23.9(t)-13(h foveol)-16(ar, intest)-32(inal, and pyl)30(or)-36.9(ic dif)-56(fer)-24(ent)-32(ia)]TJ 0 Tw (-)Tj T* [(t)-32(ion.)]TJ /T1_1 1 Tf 0.189 Tw [( Am J Surg P)17.9(athol.)]TJ /T1_2 1 Tf [( 2014 Dec;38\(12\):1618\22626. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1097/)Tj T* [(P)25(A)35(S.0000000000000283)]TJ 0 0 0 1 k /GS1 gs 0.29 Tw T* (65.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(W)12(ain)]TJ /Span<>> BDC ( )Tj EMC [(KE, Ell)-31(ingson)]TJ /Span<>> BDC ( )Tj EMC (MS, McDonald)Tj /Span<>> BDC ( )Tj EMC [(J, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. App)25(r)-24(ec)-23.9(ia)15(t)-32(ing t)-13(he )]TJ 0.184 Tw -1.796 -1.25 Td [(br)-32(oad cl)-31(inical fea)15(tur)-24(es of SMAD4 mut)15(a)15(t)-32(ion car)-24(r)-37(ier)-10(s: a mul)56(t)-32(icenter )]TJ 0.252 Tw T* [(char)-22(t r)-24(ev)-15.9(iew. )]TJ /T1_1 1 Tf (Genet Med.)Tj /T1_2 1 Tf [( 2014 A)10(ug;16\(8\):588\22693. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1038/)Tj T* (gim.2014.5)Tj 0 0 0 1 k /GS1 gs 0.048 Tw T* (66.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(P)10(ostga)15(te)]TJ /Span<>> BDC ( )Tj EMC [(AJ, W)-16(ill)]TJ /Span<>> BDC ( )Tj EMC [(OC, F)10(r)-32.9(aser)]TJ /Span<>> BDC ( )Tj EMC [(CH, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Capsule end)-15.9(oscopy for t)-13(he )]TJ -0.008 Tw -1.796 -1.25 Td [(s)26(mall bo)-14(wel in juvenile pol)35(yposis syndr)-32(ome: a case ser)-36.9(ies. )]TJ /T1_1 1 Tf 0 Tw [(Endoscop)12(y)]TJ /T1_2 1 Tf (. )Tj 0.023 Tw T* [(2009 N)-14(ov;41\(11\):1001\2264. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1055/s-0029-1215175)Tj 0 0 0 1 k /GS1 gs 0.009 Tw T* (67.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(P)40(a)15(t)-13(hol)30(o)-16(g)16(y and gene)-12(t)-31.9(ics of tumour)-10(s of t)-13(he digest)-32(i)-15.9(ve sy)-13(stem / ed. )]TJ -0.03 Tw -1.796 -1.25 Td [(A)15(al)56(t)17(onen)]TJ /Span<>> BDC ( )Tj EMC [(L.A. e)-11.9(t)]TJ /Span<>> BDC ( )Tj EMC [(al. L)70(yon : Oxfor)-23.9(d: IARC P)35(r)-24(ess ; Oxfor)-24(d U)13(ni)-16(ver)-9.9(si)-24(t)-10(y P)35(r)-24(ess )]TJ 0.023 Tw T* [(\(distr)-37(ibut)17.1(or,\). 2000; 314 p.)]TJ 0.189 Tw T* (68.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(S)-16(huss)26(man)]TJ /Span<>> BDC ( )Tj EMC [(N, W)22(e)-18(xner)]TJ /Span<>> BDC ( )Tj EMC [(SD. Col)30.1(or)-24(ec)-16(t)15(al pol)35(yps and pol)35(yposis syn)]TJ 0 Tw (-)Tj -1.796 -1.25 Td [(dr)-32(omes. )]TJ /T1_1 1 Tf 0.042 Tw 3.495 0 Td [(Gastroenterol )0.5(R)21(ep )0.5(\(Oxf\). )]TJ /T1_2 1 Tf 9.908 0 Td [(2014 F)10(eb;2\(1\):1\22615. )0.5(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1093/)Tj -13.402 -1.25 Td [(gastr)-32(o/go)17(t041)]TJ 0 0 0 1 k /GS1 gs -0.076 Tw T* (69.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(v)-15(an L)35(eer)-23.9(d)42(am)]TJ /Span<>> BDC ( )Tj EMC [(ME, R)11(o)-16(os)]TJ /Span<>> BDC ( )Tj EMC [(VH, v)-15(an Ho)-16(of)-28(t)]TJ /Span<>> BDC ( )Tj EMC [(JE, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. End)-16(oscopic mana)-17(ge)]TJ 0 Tw (-)Tj 0.1 Tw -1.796 -1.25 Td [(ment of )0.5(pol)35(yposis syndr)-32(omes: )0.5(Eur)-32(opean S)-16(o)-16(c)-23.9(ie)-12(t)-10(y of Gastr)-31.9(ointest)-32(inal )]TJ 0.163 Tw T* [(End)-16(oscopy \(ESGE\) Guidel)-31(ine. )]TJ /T1_1 1 Tf 0 Tw [(Endoscop)12.1(y)]TJ /T1_2 1 Tf 0.163 Tw (. 2019 Sep;51\(9\):877\226895. )Tj 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1055/a-0965-0605)Tj 0 0 0 1 k /GS1 gs 0.207 Tw 27.208 65 Td (70.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(N)-14(o)-14(wick)-15.9(i)]TJ /Span<>> BDC ( )Tj EMC (MJ, Bishop)Tj /Span<>> BDC ( )Tj EMC [(PR. Successful end)-16(oscopic r)-23.9(emov)-15(al of an )]TJ 0.316 Tw -1.796 -1.25 Td [(appendiceal pol)35(yp in a child wi)-24(t)-13(h juvenile pol)35(yposis syndr)-32(ome. )]TJ /T1_1 1 Tf 0.015 Tc 0.546 Tw T* (Gastrointest Endosc.)Tj /T1_2 1 Tf [( 2011 A)10.1(ug;74\(2\):441\2263. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs -0.015 Tw (10.1016/j.)Tj 0 Tc 0 Tw T* (gie.2011.01.027)Tj 0 0 0 1 k /GS1 gs -0.043 Tw T* (71.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Br)-32(osens)]TJ /Span<>> BDC ( )Tj EMC [(L)-35(A, v)-15(an Ha)15(t)-30(tem)]TJ /Span<>> BDC ( )Tj EMC [(A, Hyl)-31(ind)]TJ /Span<>> BDC ( )Tj EMC [(LM, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. R)-24(isk of col)30(or)-23.9(ec)-16(t)15(al can)]TJ 0 Tw (-)Tj 0.075 Tw -1.796 -1.25 Td [(cer in juvenile pol)35(yposis. )]TJ /T1_1 1 Tf 0 Tw (Gut.)Tj /T1_2 1 Tf 0.075 Tw [( 2007 Jul;56\(7\):965\2267. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1136/)Tj T* (gut.2006.116913)Tj 0 0 0 1 k /GS1 gs 0.052 Tw T* (72.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Oncel)Tj /Span<>> BDC ( )Tj EMC 2.522 0 Td [(M, )0.5(Chur)-31.9(ch)]TJ /Span<>> BDC ( )Tj EMC 4.228 0 Td [(JM, )0.6(R)12.9(emzi)]TJ /Span<>> BDC ( )Tj EMC 4.272 0 Td [(FH, )0.5(e)-11.9(t)]TJ /Span<>> BDC ( )Tj EMC 2.622 0 Td [(al. )0.6(Col)30(onic )0.5(sur)-32(ger)-23.9(y )0.5(in )0.6(p)32(a)15(t)-32(ients )]TJ 0.135 Tw -15.44 -1.25 Td [(wi)-24(t)-12.9(h juvenile pol)35(yposis syndr)-32(ome: a case ser)-36.9(ies. )]TJ /T1_1 1 Tf [(Dis Colon R)21(ectum. )]TJ /T1_2 1 Tf 0.111 Tw T* [(2005 Jan;48\(1\):49\22655; discussion 55-6. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1007/s10350-004-)Tj T* (0749-y)Tj 0 0 0 1 k /GS1 gs -0.076 Tw T* (73.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(v)-15(an L)35(eer)-23.9(d)42(am)]TJ /Span<>> BDC ( )Tj EMC [(ME, R)11(o)-16(os)]TJ /Span<>> BDC ( )Tj EMC [(VH, v)-15(an Ho)-16(of)-28(t)]TJ /Span<>> BDC ( )Tj EMC [(JE, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. End)-16(oscopic mana)-17(ge)]TJ 0 Tw (-)Tj 0.1 Tw -1.796 -1.25 Td [(ment of )0.5(pol)35(yposis syndr)-32(omes: )0.5(Eur)-32(opean S)-16(o)-16(c)-23.9(ie)-12(t)-10(y of Gastr)-31.9(ointest)-32(inal )]TJ 0.163 Tw T* [(End)-16(oscopy \(ESGE\) Guidel)-31(ine. )]TJ /T1_1 1 Tf 0 Tw [(Endoscop)12.1(y)]TJ /T1_2 1 Tf 0.163 Tw (. 2019 Sep;51\(9\):877\226895. )Tj 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1055/a-0965-0605)Tj 0 0 0 1 k /GS1 gs 0.014 Tc 0.502 Tw -1.847 -1.25 Td (74.)Tj /Span<>> BDC ( )Tj EMC 1.851 0 Td (\205\036\007\016\027\017\027)Tj /Span<>> BDC ( )Tj EMC (\204.\236., \202\004\022\026\f\024\r)Tj /Span<>> BDC ( )Tj EMC (\221.\222., \207\024\035\024\021\017\027\026)Tj /Span<>> BDC ( )Tj EMC (\214.\200., \017)Tj /Span<>> BDC ( )Tj EMC [(\f\024\026\r\021.)14( )]TJ 0 Tc -0.08 Tw -1.851 -1.25 Td (\215\030\026\022\021\017\004\036\f\022\017\036 \030\036\022\024\n\036\027\ \007\026\006\017\017 \023\024)Tj /Span<>> BDC ( )Tj EMC (\035\036\022\026\030\f\021\r\036\027\027\024\n\031 \035\036\004\036\027\017\ \033 \030\026\022\026 \024\002\024)Tj 0 Tw (-)Tj 0.034 Tw T* (\007\024\004\027\024\005 \022\017\001\022\017 \017)Tj /Span<>> BDC ( )Tj EMC (\030\036\022\021\024\f\017\020\n\024\017\007\027\024\020\024 \f\024\036\007\ \017\027\036\027\017\016. )Tj /T1_1 1 Tf 0 Tw (\221\023\n\013\026\006\031\t\024\027\031\021\021\020\031 )Tj T* (\n\033\205\004\n\023\025)Tj /T1_2 1 Tf 0.013 Tw [(. 2021;11\(3s2-1\):330\226372. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.18027/2224-5057-2021-)Tj T* (11-3s2-22)Tj 0 0 0 1 k /GS1 gs 0.294 Tw [( / F)10(ed)17(y)22(anin)]TJ /Span<>> BDC ( )Tj EMC [(M.Y)35.1(u., A)-25(chk)-17(asov)]TJ /Span<>> BDC ( )Tj EMC [(S.I., Bol)30.1(o)17(t)-32(ina)]TJ /Span<>> BDC ( )Tj EMC [(L.V., e)-12(t)]TJ /Span<>> BDC ( )Tj EMC (al. )Tj 0.132 Tw T* [(P)35(r)-33(a)-17(c)-15.9(t)-32(ical r)-24(ecommend)42(a)15(t)-32(ions for t)-12.9(he dr)-22(ug tr)-24(ea)15(tment of col)30(on cancer )]TJ 0.072 Tw T* [(and r)-24(ec)-16(t)17(osigmoid junc)-15.9(t)-32(ion.)]TJ /T1_1 1 Tf [( Malignant T)57.1(umors)]TJ /T1_2 1 Tf (. 2021;11\(3s2-1\):330\226)Tj 0.023 Tw T* [(372. \(in Russ\). d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.18027/2224-5057-2021-11-3s2-22)Tj 0 0 0 1 k /GS1 gs 0.016 Tc 0.593 Tw T* (75.)Tj /Span<>> BDC ( )Tj EMC 1.861 0 Td (\234\036\035\t\020\017\027)Tj /Span<>> BDC ( )Tj EMC (\236.\202., \222\n\016\027\017\021\024\r)Tj /Span<>> BDC ( )Tj EMC (\213.\203., \025\031\006\036\r)Tj /Span<>> BDC ( )Tj EMC (\221.\222., \017)Tj /Span<>> BDC ( )Tj EMC [(\f\024\026\r\021.)16( )]TJ 0.024 Tc 0.868 Tw -1.861 -1.25 Td (\202\007\036\027\024\n\026\021\024\027\t\005 \023\024\035\017\023\024\027\ \t\005 \f\017\027\007\030\024\n. )Tj /T1_1 1 Tf -0.024 Tw (\222\n\023\n\033\032\n\013\024\n\023\n\202\025\002)Tj /T1_2 1 Tf 0 Tc 0 Tw (. )Tj 0.005 Tc 0.35 Tw T* [(2022;21\(2\):10\22624. d)-16.2(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs -0.005 Tw (10.33878/2073-7556-2022-21-2-10-24)Tj 0 0 0 1 k /GS1 gs 0 Tc 0.355 Tw ( /)Tj 0.132 Tw T* [(S)-16(hel)35(ygin)]TJ /Span<>> BDC ( )Tj EMC [(Y.A., Imy)22(ani)-24(t)17(ov)]TJ /Span<>> BDC ( )Tj EMC [(E.N., K)25(utsev)]TJ /Span<>> BDC ( )Tj EMC [(S.I., e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. A)15(denoma)15(t)17.1(ous pol)]TJ 0 Tw (-)Tj 0.004 Tc 0.349 Tw T* [(yposis syndr)-31.8(ome. )]TJ /T1_1 1 Tf -0.004 Tw [(K)18.1(olop)46.1(roktologia)]TJ /T1_2 1 Tf 0.349 Tw [(. 2022;21\(2\):10\22624. \(in Russ\).)4( )]TJ 0 Tc 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.33878/2073-7556-2022-21-2-10-24)Tj 0 0 0 1 k /GS1 gs 0.027 Tw -1.847 -1.25 Td (76.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Cohen)Tj /Span<>> BDC ( )Tj EMC (S, Hyer)Tj /Span<>> BDC ( )Tj EMC (W, Mas)Tj /Span<>> BDC ( )Tj EMC [(E, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Mana)-17(gement of Juvenile P)10(ol)35(yposis )]TJ 0.149 Tw -1.796 -1.25 Td [(Syndr)-32(ome in Childr)-24(en and A)15(d)-16(olescents: A P)10(osi)-23.9(t)-32(ion P)40(aper F)10(r)-32(om t)-13(he )]TJ -0.008 Tw T* [(ESPGH)49(A)51.1(N P)10(ol)35(yposis W)20(or)-24(k)-16(ing G)20(r)-31.9(oup. )]TJ /T1_1 1 Tf [(J P)15(ediatr Gastroenterol N)21(utr. 2)]TJ /T1_2 1 Tf 0 Tw (019 )Tj 0.023 Tw T* [(Mar;68\(3\):453\226462. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1097/MPG.0000000000002246)Tj 0 0 0 1 k /GS1 gs 0.207 Tw T* (77.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (\206\026\035\022\024\r\026)Tj /Span<>> BDC ( )Tj EMC (\003.\200., \025\026\001\017\027)Tj /Span<>> BDC ( )Tj EMC (\221.\200., \203\017\022\024\027\024\r)Tj /Span<>> BDC ( )Tj EMC (\213.\214., \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. \221\021\026\027\007\026\030\021\t )Tj -0.059 Tw -1.796 -1.25 Td (\022\026\004\036\f\021\r\036\027\027\024\005 \022\024\035\024\027\024\f\022\ \024\023\017\017 \(\023\024\f\024\002\017\036 \007\035\016 \r\030\026\004\ \036\005\). )Tj /T1_1 1 Tf 0 Tw (\200\n\013\026\016\026\024\031\023\022\021\026\002 )Tj T* (\202\026\t\024\032\n\r\021\024\031\032\n\023\n\202\025\002. )Tj /T1_2 1 Tf 0.04 Tw 8.897 0 Td [(2018;7\(4\):107133. / Galkov)-15(a)]TJ /Span<>> BDC ( )Tj EMC [(Z.V., K)-16(ashin)]TJ /Span<>> BDC ( )Tj EMC (S.V., )Tj 0.012 Tc 0.446 Tw -8.897 -1.25 Td (Nikonov)Tj /Span<>> BDC ( )Tj EMC 4.053 0 Td [(E.L., )0.6(e)-12.1(t)]TJ /Span<>> BDC ( )Tj EMC 4 0 Td [(al. )0.6(Q)-16.1(ual)-31.1(i)-24(t)-10(y )0.6(col)30(onoscopy )0.5(st)14.9(and)41.9(ar)-24(ds )0.5(\(d)-16.1(o)-16(c)-16.1(t)16.9(or\245s)12( )]TJ 0.016 Tc -0.016 Tw -8.053 -1.25 Td (guide\). )Tj /T1_1 1 Tf 0.581 Tw 3.872 0 Td [(R)22.1(ussian Jour)-13.9(nal of Evidence-Based Gastroenterology.)16( )]TJ /T1_2 1 Tf 0 Tc 0.023 Tw -3.872 -1.25 Td (2018;7\(4\):107133. \(in Russ.\).)Tj -0.007 Tw T* (78.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(P)30(enna)-24(zio)]TJ /Span<>> BDC ( )Tj EMC [(M, R)11(ond)-16(ono)17(t)-30(t)-32(i)]TJ /Span<>> BDC ( )Tj EMC [(E, Despo)17(t)-30(t)]TJ /Span<>> BDC ( )Tj EMC [(EJ, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Small-bo)-13.9(wel capsule )]TJ 0.054 Tw -1.796 -1.25 Td [(end)-16(oscopy and dev)-16(ice-assisted enter)-32(oscopy for dia)-17(gnosis and tr)-24(ea)15(t)]TJ 0 Tw (-)Tj 0.033 Tw T* [(ment of s)26(mall-bo)-13.9(wel disor)-24(der)-10(s: Eur)-32(opean S)-16(o)-16(c)-24(ie)-11.9(t)-10(y of Gastr)-31.9(ointest)-32(inal )]TJ 0.004 Tc 0.35 Tw T* [(End)-16.1(oscopy )0.5(\(ESGE\) )0.5(Guidel)-31.1(ine)]TJ /Span<>> BDC ( )Tj EMC 12.71 0 Td [(\227 )0.5(U)12.9(pd)41.9(a)14.9(te 2022. )]TJ /T1_1 1 Tf -0.004 Tw 7.912 0 Td [(Endoscop)11.9(y)]TJ /T1_2 1 Tf 0.35 Tw [(. )0.5(2023)4( )]TJ 0 Tc 0.023 Tw -20.622 -1.25 Td [(Jan;55\(1\):58\22695. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1055/a-1973-3796)Tj 0 0 0 1 k /GS1 gs 0.109 Tw T* (79.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Bol)-16(and)]TJ /Span<>> BDC ( )Tj EMC [(CR, Id)-15.9(os)]TJ /Span<>> BDC ( )Tj EMC [(GE, Dur)-14.9(no)]TJ /Span<>> BDC ( )Tj EMC [(C, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Dia)-17(gnosis and Mana)-17(gement )]TJ 0.306 Tw -1.796 -1.25 Td [(of Cancer R)-24(isk in t)-13(he Gastr)-31.9(ointest)-32(inal Hamar)-22(t)17(oma)15(t)17(ous P)10(ol)35(yposis )]TJ 0.048 Tw T* [(Syndr)-32(omes: R)13(ecommend)42(a)15(t)-31.9(ions F)9.9(r)-31.9(om t)-12.9(he US Mul)56.1(t)-32(i-S)-16(o)-16(c)-24(ie)-12(t)-9.9(y T)40(ask F)10(or)-32(ce )]TJ 0.142 Tw T* [(on Col)30(or)-23.9(ec)-16(t)15(al Cancer. )]TJ /T1_1 1 Tf (Am J Gastroenterol)Tj /T1_2 1 Tf (. 2022 Jun 1;117\(6\):846\226)Tj 0.023 Tw T* [(864. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.14309/ajg.0000000000001755)Tj 0 0 0 1 k /GS1 gs 0.155 Tw T* (80.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Ma)15(tsumo)17.1(t)17(o)]TJ /Span<>> BDC ( )Tj EMC [(T, U)12(meno)]TJ /Span<>> BDC ( )Tj EMC (J, Jimbo)Tj /Span<>> BDC ( )Tj EMC [(K. e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. )0.5(Cl)-31(inical Guidel)-31(ines )0.5(for )]TJ 0.006 Tc 0.349 Tw -1.796 -1.25 Td [(Dia)-16.7(gnosis and Mana)-16.7(gement of Juvenile P)10.3(ol)35.3(yposis Syndr)-31.7(ome in)6( )]TJ 0 Tc 0.23 Tw T* [(Childr)-23.9(en and A)15(dul)56.1(ts-Second)42(ar)-24(y P)20(ubl)-31(ica)15(t)-32(ion. )]TJ /T1_1 1 Tf [(J Anus R)21(ectum Colon)]TJ /T1_2 1 Tf 0 Tw (. )Tj 0.023 Tw T* [(2023 Ap)25(r 25;7\(2\):115\226125. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw [(10.23922/jar)-31.9(c.2023-002)]TJ /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\214)10(\211\036\033 \035\030\032\t\033)30(\b)42(\032)-21(\240\033\233)]TJ 57.136 0 Td (REVIEW)Tj /T1_3 1 Tf 25 0 0 25 504.6022 56.0378 Tm (151)Tj ET endstream endobj 677 0 obj <>/Border[0 0 0]/H/N/Rect[233.71 738.512 263.622 729.056]/Subtype/Link/Type/Annot>> endobj 678 0 obj <>/Border[0 0 0]/H/N/Rect[42.5197 728.512 94.4151 719.216]/Subtype/Link/Type/Annot>> endobj 679 0 obj <>/Border[0 0 0]/H/N/Rect[206.151 698.512 263.622 689.056]/Subtype/Link/Type/Annot>> endobj 680 0 obj <>/Border[0 0 0]/H/N/Rect[42.5197 688.512 75.1195 679.216]/Subtype/Link/Type/Annot>> endobj 681 0 obj <>/Border[0 0 0]/H/N/Rect[112.94 648.512 194.747 639.216]/Subtype/Link/Type/Annot>> endobj 682 0 obj <>/Border[0 0 0]/H/N/Rect[57.2978 598.512 151.21 589.216]/Subtype/Link/Type/Annot>> endobj 683 0 obj <>/Border[0 0 0]/H/N/Rect[57.2978 528.512 127.305 519.216]/Subtype/Link/Type/Annot>> endobj 684 0 obj <>/Border[0 0 0]/H/N/Rect[195.319 498.512 257.095 489.056]/Subtype/Link/Type/Annot>> endobj 685 0 obj <>/Border[0 0 0]/H/N/Rect[222.935 478.512 263.622 469.056]/Subtype/Link/Type/Annot>> endobj 686 0 obj <>/Border[0 0 0]/H/N/Rect[42.5197 468.512 126.911 459.216]/Subtype/Link/Type/Annot>> endobj 687 0 obj <>/Border[0 0 0]/H/N/Rect[57.2978 438.512 123.21 429.216]/Subtype/Link/Type/Annot>> endobj 688 0 obj <>/Border[0 0 0]/H/N/Rect[233.71 398.512 263.622 389.056]/Subtype/Link/Type/Annot>> endobj 689 0 obj <>/Border[0 0 0]/H/N/Rect[42.5197 388.512 120.632 379.216]/Subtype/Link/Type/Annot>> endobj 690 0 obj <>/Border[0 0 0]/H/N/Rect[233.71 358.512 263.622 349.056]/Subtype/Link/Type/Annot>> endobj 691 0 obj <>/Border[0 0 0]/H/N/Rect[42.5197 348.512 79.2554 339.216]/Subtype/Link/Type/Annot>> endobj 692 0 obj <>/Border[0 0 0]/H/N/Rect[143.366 318.512 226.021 309.216]/Subtype/Link/Type/Annot>> endobj 693 0 obj <>/Border[0 0 0]/H/N/Rect[233.71 268.512 263.622 259.056]/Subtype/Link/Type/Annot>> endobj 694 0 obj <>/Border[0 0 0]/H/N/Rect[42.5197 258.512 89.1513 249.216]/Subtype/Link/Type/Annot>> endobj 695 0 obj <>/Border[0 0 0]/H/N/Rect[57.2978 218.512 128.545 209.216]/Subtype/Link/Type/Annot>> endobj 696 0 obj <>/Border[0 0 0]/H/N/Rect[460.477 718.512 496.063 709.056]/Subtype/Link/Type/Annot>> endobj 697 0 obj <>/Border[0 0 0]/H/N/Rect[274.961 708.512 328.032 699.216]/Subtype/Link/Type/Annot>> endobj 698 0 obj <>/Border[0 0 0]/H/N/Rect[466.151 688.512 496.063 679.056]/Subtype/Link/Type/Annot>> endobj 699 0 obj <>/Border[0 0 0]/H/N/Rect[274.961 678.512 330.656 669.216]/Subtype/Link/Type/Annot>> endobj 700 0 obj <>/Border[0 0 0]/H/N/Rect[425.407 648.512 496.063 639.216]/Subtype/Link/Type/Annot>> endobj 701 0 obj <>/Border[0 0 0]/H/N/Rect[274.961 638.512 297.336 629.216]/Subtype/Link/Type/Annot>> endobj 702 0 obj <>/Border[0 0 0]/H/N/Rect[289.739 598.512 360.986 589.216]/Subtype/Link/Type/Annot>> endobj 703 0 obj <>/Border[0 0 0]/H/N/Rect[405.703 558.512 496.063 549.056]/Subtype/Link/Type/Annot>> endobj 704 0 obj <>/Border[0 0 0]/H/N/Rect[274.961 548.512 307.704 539.216]/Subtype/Link/Type/Annot>> endobj 705 0 obj <>/Border[0 0 0]/H/N/Rect[339.513 518.512 462.616 509.216]/Subtype/Link/Type/Annot>> endobj 706 0 obj <>/Border[0 0 0]/H/N/Rect[359.572 488.512 487.817 479.216]/Subtype/Link/Type/Annot>> endobj 707 0 obj <>/Border[0 0 0]/H/N/Rect[289.739 458.512 416.546 449.216]/Subtype/Link/Type/Annot>> endobj 708 0 obj <>/Border[0 0 0]/H/N/Rect[356.94 418.512 466.94 409.216]/Subtype/Link/Type/Annot>> endobj 709 0 obj <>/Border[0 0 0]/H/N/Rect[348.845 308.512 420.092 299.216]/Subtype/Link/Type/Annot>> endobj 710 0 obj <>/Border[0 0 0]/H/N/Rect[306.157 258.512 416.373 249.216]/Subtype/Link/Type/Annot>> endobj 711 0 obj <>/Border[0 0 0]/H/N/Rect[380.249 218.512 459.553 209.216]/Subtype/Link/Type/Annot>> endobj 746 0 obj <> endobj 745 0 obj <> endobj 744 0 obj <> endobj 743 0 obj <> endobj 742 0 obj <> endobj 741 0 obj <> endobj 740 0 obj <> endobj 739 0 obj <> endobj 738 0 obj <> endobj 737 0 obj <> endobj 736 0 obj <> endobj 735 0 obj <> endobj 734 0 obj <> endobj 733 0 obj <> endobj 732 0 obj <> endobj 731 0 obj <> endobj 730 0 obj <> endobj 729 0 obj <> endobj 728 0 obj <> endobj 727 0 obj <> endobj 726 0 obj <> endobj 725 0 obj <> endobj 724 0 obj <> endobj 723 0 obj <> endobj 722 0 obj <> endobj 721 0 obj <> endobj 720 0 obj <> endobj 719 0 obj <> endobj 718 0 obj <> endobj 717 0 obj <> endobj 716 0 obj <> endobj 715 0 obj <> endobj 714 0 obj <> endobj 713 0 obj <> endobj 712 0 obj <> endobj 39 0 obj <> endobj 40 0 obj <> endobj 41 0 obj <> endobj 42 0 obj <> endobj 43 0 obj <> endobj 767 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 768 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 769 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 770 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 771 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 777 0 obj [779 0 R 780 0 R 781 0 R 782 0 R 783 0 R 784 0 R 785 0 R 786 0 R 787 0 R 788 0 R 789 0 R 790 0 R 791 0 R 792 0 R 793 0 R 794 0 R 795 0 R 796 0 R 797 0 R 798 0 R 799 0 R 800 0 R 801 0 R 802 0 R 803 0 R 804 0 R 805 0 R 806 0 R 807 0 R 808 0 R 809 0 R 810 0 R 811 0 R 812 0 R 813 0 R 814 0 R 815 0 R 816 0 R 817 0 R 818 0 R 819 0 R 820 0 R 821 0 R 822 0 R 823 0 R 824 0 R] endobj 778 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.088 Tw 8 0 0 8 70.8661 731.2159 Tm (18.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Hor)-24(r)-36.9(illeno)]TJ /Span<>> BDC ( )Tj EMC [(EG, E)15(ck)10(er)-22(t)]TJ /Span<>> BDC ( )Tj EMC [(C, A)-25(ck)10(er)-16(man)]TJ /Span<>> BDC ( )Tj EMC [(L)65(V. P)10(ol)35(yps of t)-13(he r)-23.9(ec)-16(tum and )]TJ 0.273 Tw -1.796 -1.25 Td [(col)30(on in childr)-23.9(en. )]TJ /T1_1 1 Tf 0 Tw (Cancer.)Tj /T1_0 1 Tf 0.273 Tw [( 1957;10:1210\22620. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1002/1097-)Tj 0 -1.25 TD (0142\(195711/12\)10:6)Tj 0 0 0 1 k /GS1 gs 0.023 Tw /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (1210::aid-cncr2820100619)Tj /Span<>> BDC ( )Tj EMC (>)Tj /Span<>> BDC ( )Tj EMC (3.0.co;2-2)Tj 0.124 Tw T* (19.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(V)30(eale)]TJ /Span<>> BDC ( )Tj EMC (AM, McColl)Tj /Span<>> BDC ( )Tj EMC [(I, Busse)-11(y)]TJ /Span<>> BDC ( )Tj EMC [(HJ, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Juvenile pol)35(yposis col)-31(i)]TJ /T1_1 1 Tf (. J )Tj 0.023 Tw -1.796 -1.25 Td (Med Genet.)Tj /T1_0 1 Tf [( 1966 Mar;3\(1\):5\22616. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1136/jmg.3.1.5)Tj 0 0 0 1 k /GS1 gs 0.122 Tw T* (20.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Zbuk)Tj /Span<>> BDC ( )Tj EMC (KM, Eng)Tj /Span<>> BDC ( )Tj EMC [(C. Hamar)-22(t)17.1(oma)15(t)17(ous pol)35(yposis syndr)-31.9(omes. )]TJ /T1_1 1 Tf [(N)18.1(at Clin )]TJ 0.248 Tw -1.796 -1.25 Td (Pract Gastroenterol Hepatol.)Tj /T1_0 1 Tf [( 2007;4:492\226502. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1038/ncpg)Tj (-)Tj T* [(ast)-13(hep0902)]TJ 0 0 0 1 k /GS1 gs 0.154 Tw T* (21.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Cho)-14(w)]TJ /Span<>> BDC ( )Tj EMC 2.517 0 Td [(E, )0.5(Ma)-17(cr)-33(ae)]TJ /Span<>> BDC ( )Tj EMC [(F. )0.6(A r)-23.9(ev)-16(iew )0.5(of )0.5(juvenile )0.5(pol)35(yposis )0.5(syndr)-32(ome)]TJ /T1_1 1 Tf [(. )0.5(J )]TJ 0.348 Tw -4.312 -1.25 Td (Gastroenterol Hepatol.)Tj /T1_0 1 Tf [( 2005;20:1634\2261640. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1111/j.1440-)Tj T* (1746.2005.03865.x)Tj 0 0 0 1 k /GS1 gs 0.012 Tw T* (22.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Giar)-23.9(diell)30(o)]TJ /Span<>> BDC ( )Tj EMC [(FM, Hamil)56(t)17(on)]TJ /Span<>> BDC ( )Tj EMC [(SR, K)25(er)-15(n)]TJ /Span<>> BDC ( )Tj EMC [(SE, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Col)30.1(or)-24(ec)-16(t)15(al neopl)-16(asia in )]TJ 0.138 Tw -1.796 -1.25 Td [(juvenile pol)35(yposis or juvenile pol)35(yps. )]TJ /T1_1 1 Tf (Arch Dis Child)Tj /T1_0 1 Tf (. 1991;66:971\226)Tj 0.023 Tw T* [(975. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1136/adc.66.8.971)Tj 0 0 0 1 k /GS1 gs 0.132 Tw T* (23.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Nugent)Tj /Span<>> BDC ( )Tj EMC [(KP, T)40(albo)17.1(t)]TJ /Span<>> BDC ( )Tj EMC (IC, Hodgson)Tj /Span<>> BDC ( )Tj EMC [(S)-12.9(V, e)-11.9(t)]TJ /Span<>> BDC ( )Tj EMC [(al. S)-16(ol)-31(i)-24(t)15(ar)-23.9(y juvenile pol)]TJ 0 Tw (-)Tj 0.317 Tw -1.796 -1.25 Td [(yps: no)17(t a mar)-23.9(k)10(er for subsequent )0.5(mal)-31(ignancy. )]TJ /T1_1 1 Tf 0 Tw 20.7 0 Td (Gastroenterology)Tj /T1_0 1 Tf (. )Tj 0.023 Tw -20.7 -1.25 Td [(1993;105:698\226700. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1016/0016-5085\(93\)90885-g)Tj 0 0 0 1 k /GS1 gs 0.034 Tw T* (24.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Jelsig)Tj /Span<>> BDC ( )Tj EMC 2.611 0 Td [(AM, )0.6(W)15.9(ull)35.1(um)]TJ /Span<>> BDC ( )Tj EMC 4.867 0 Td [(L, )0.6(K)25(uhlmann)]TJ /Span<>> BDC ( )Tj EMC 5.173 0 Td [(TP, )0.5(e)-11.9(t)]TJ /Span<>> BDC ( )Tj EMC 2.521 0 Td [(al. )0.6(Cancer )0.5(r)-37(isk )0.6(and )0.5(mor)-22(t)15.1(al)]TJ 0 Tw (-)Tj 0.226 Tw -16.968 -1.25 Td [(i)-24(t)-10(y in p)32(a)15(t)-31.9(ients wi)-24(t)-12.9(h sol)-31(i)-23.9(t)15(ar)-24(y juvenile pol)35(yps-A na)15(t)-32(ionwide cohor)-21.9(t )]TJ 0.058 Tw T* [(stud)17(y wi)-23.9(t)-13(h ma)15(tched contr)-32(ols. )]TJ /T1_1 1 Tf [(U)22(nited European Gastroenterol)]TJ /Span<>> BDC ( )Tj EMC (J. )Tj /T1_0 1 Tf 0 Tw (2023 )Tj 0.023 Tw T* [(O)-16(c)-16(t;11\(8\):745\226749. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1002/ueg2.12441)Tj 0 0 0 1 k /GS1 gs 0.238 Tw T* (25.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Guill\351n-P)10.1(once)]TJ /Span<>> BDC ( )Tj EMC [(C, Ser)-24(r)-32.9(ano)]TJ /Span<>> BDC ( )Tj EMC [(R, S\341nchez-Her)-32.9(as)]TJ /Span<>> BDC ( )Tj EMC [(A)44(B, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Cl)-31(inical )]TJ 0.036 Tw -1.796 -1.25 Td [(guidel)-30.9(ine seom: her)-24(edi)-23.9(t)15(ar)-24(y col)30(or)-24(ec)-16(t)15.1(al cancer. )]TJ /T1_1 1 Tf [(Clin T)56(ransl Oncol. )]TJ /T1_0 1 Tf 0 Tw (2015 )Tj 0.023 Tw T* [(Dec;17\(12\):962\22671. d)-15.9(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1007/s12094-015-1439-z)Tj 0 0 0 1 k /GS1 gs -0.032 Tw T* (26.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(U)13(p)32(adhy)22(a)15(y)22(a)]TJ /Span<>> BDC ( )Tj EMC [(VD, )0.5(Gangop)32(adhy)22(a)15(y)22(a)]TJ /Span<>> BDC ( )Tj EMC [(A)51.1(N, S)-16(har)-16(ma)]TJ /Span<>> BDC ( )Tj EMC 17.015 0 Td [(SP, )0.5(e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. )0.5(Juvenile )0.5(pol)]TJ 0 Tw (-)Tj 0.1 Tw -18.811 -1.25 Td [(yposis syndr)-32(ome. )]TJ /T1_1 1 Tf [(J Indian Assoc P)15(ediatr Surg.)]TJ /T1_0 1 Tf [( 2008 O)-16(c)-16(t;13\(4\):128\226)]TJ 0.023 Tw T* [(31. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.4103/0971-9261.44762)Tj 0 0 0 1 k /GS1 gs 0.17 Tw T* (27.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Br)-32(osens)]TJ /Span<>> BDC ( )Tj EMC [(L)-34.9(A, v)-15(an Ha)15(t)-30(tem)]TJ /Span<>> BDC ( )Tj EMC [(W)31(A, Jansen)]TJ /Span<>> BDC ( )Tj EMC [(M, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Gastr)-31.9(ointest)-31.9(inal )]TJ 0.017 Tc 0.605 Tw -1.796 -1.25 Td [(pol)35.3(yposis syndr)-31.6(omes. )]TJ /T1_1 1 Tf [(Cur)-15.6(r Mol )0.5(Med.)]TJ /T1_0 1 Tf [( 2007 F)10.4(eb;7\(1\):29\22646.)17( )]TJ 0 Tc 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.2174/156652407779940404)Tj 0 0 0 1 k /GS1 gs 0.203 Tw -1.847 -1.25 Td (28.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Sa)-17(cha)15(tell)30.1(o)]TJ /Span<>> BDC ( )Tj EMC [(CR, G)20(r)-36.9(if)-56(fen WO Jr. Her)-23.9(edi)-24(t)15(ar)-24(y pol)35(ypoid diseases of )]TJ 0.031 Tw -1.796 -1.25 Td [(t)-13(he gastr)-32(ointest)-31.9(inal tr)-32.9(a)-17(c)-16(t: a w)-13.9(or)-24(k)-16(ing cl)-16(assif)-28(ica)15(t)-32(ion. )]TJ /T1_1 1 Tf (Am J Surg.)Tj /T1_0 1 Tf ( 1975 )Tj 0.023 Tw T* [(F)10(eb;129\(2\):198\226203. d)-15.9(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1016/0002-9610\(75\)90298-6)Tj 0 0 0 1 k /GS1 gs 0.17 Tw T* (29.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Delna)15(t)-30(te)]TJ /Span<>> BDC ( )Tj EMC [(C, Sanl)-16(av)-16(ille)]TJ /Span<>> BDC ( )Tj EMC [(D, M)-24(ougeno)17.1(t)]TJ /Span<>> BDC ( )Tj EMC [(JF, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Cont)-32(iguous gene )]TJ 0.001 Tc 0.35 Tw -1.796 -1.25 Td [(dele)-12.2(t)-32.2(ion wi)-24.2(t)-13.1(hin chr)-32.2(omosome ar)-16.2(m 10q is asso)-16.2(c)-24.2(ia)14.8(ted wi)-24.2(t)-13.2(h juve)]TJ 0 Tc 0 Tw (-)Tj 0.01 Tc 0.362 Tw T* [(nile )0.5(pol)35.3(yposis of )0.5(inf)16.4(ancy, )0.5(r)-23.7(eflec)-15.7(t)-31.7(ing )0.5(co)-15.6(oper)-32.6(a)15.3(t)-31.7(ion )0.5(be)-11.6(t)-31.7(ween )0.5(t)-12.7(he)10( )]TJ 0 Tc 0.112 Tw T* [(BMPR1A and PTEN tumor-supp)25(r)-23.9(essor genes. )]TJ /T1_1 1 Tf (Am J Hum Genet. )Tj /T1_0 1 Tf 0 Tw (2006 )Tj 0.023 Tw T* [(Jun;78\(6\):1066\22674. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1086/504301)Tj 0 0 0 1 k /GS1 gs 0.097 Tw T* (30.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(S)15(tem)10(per)]TJ /Span<>> BDC ( )Tj EMC [(T)25(J, K)25.1(ent)]TJ /Span<>> BDC ( )Tj EMC [(TH, Summer)-10(s)]TJ /Span<>> BDC ( )Tj EMC [(RW. Juvenile pol)35(yposis and gas)]TJ 0 Tw (-)Tj 0.048 Tw -1.796 -1.25 Td [(tr)-32(ointest)-31.9(inal car)-32(c)-24(inoma. A stud)17.1(y of a k)-15.9(indr)-24(ed. )]TJ /T1_1 1 Tf [(Ann Inter)-14(n Med.)]TJ /T1_0 1 Tf ( 1975 )Tj 0.023 Tw T* [(N)-14(ov;83\(5\):639\22646. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.7326/0003-4819-83-5-639)Tj 0 0 0 1 k /GS1 gs 0.167 Tw T* (31.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Ar)-24(e)-11.9(tz)]TJ /Span<>> BDC ( )Tj EMC [(S, S)15(t)-32(ienen)]TJ /Span<>> BDC ( )Tj EMC (D, Uhlhaas)Tj /Span<>> BDC ( )Tj EMC [(S, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. High p)25(r)-32(opor)-21.9(t)-32(ion of l)-16(ar)-31.9(ge )]TJ 0.183 Tw -1.796 -1.25 Td [(genomic dele)-12(t)-32(ions and a geno)17(t)-10(ype pheno)17(t)-9.9(ype upd)42(a)15(te in 80 unr)-23.9(e)]TJ 0 Tw (-)Tj 0.09 Tw T* [(l)-16(a)15(ted )0.6(f)16(amil)-31(ies )0.6(wi)-24(t)-13(h )0.6(juvenile )0.5(pol)35.1(yposis )0.5(syndr)-32(ome. )]TJ /T1_1 1 Tf 20.126 0 Td [(J )0.5(Med )0.6(Genet.)]TJ /T1_0 1 Tf [( )0.6(2007 )]TJ 0.023 Tw -20.126 -1.25 Td [(N)-14(ov;44\(11\):702\2269. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1136/jmg.2007.052506)Tj 0 0 0 1 k /GS1 gs 0.131 Tw T* (32.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Handr)-33(a-L)35.1(uca)]TJ /Span<>> BDC ( )Tj EMC [(A, Condr)-31.9(oyer)]TJ /Span<>> BDC ( )Tj EMC [(C, de M)-24(oncui)-24(t)]TJ /Span<>> BDC ( )Tj EMC [(C, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. V)30(essels\245 mor)]TJ 0 Tw 25.49 0 Td (-)Tj 0.032 Tw -27.286 -1.25 Td [(phol)30(o)-16(g)16(y in SMAD4 and BMPR1A-r)-23.9(el)-16(a)15.1(ted juvenile pol)35(yposis. )]TJ /T1_1 1 Tf (Am J Med )Tj 0.023 Tw T* (Genet)Tj /Span<>> BDC ( )Tj EMC (A.)Tj /T1_0 1 Tf [( 2005 O)-16(c)-16(t 1;138A\(2\):113\2267. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1002/ajmg.a.30897)Tj 0 0 0 1 k /GS1 gs 0.015 Tw T* (33.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(F)10(r)-37(iedl)]TJ /Span<>> BDC ( )Tj EMC (W, Uhlhaas)Tj /Span<>> BDC ( )Tj EMC [(S, S)-24(chulmann)]TJ /Span<>> BDC ( )Tj EMC [(K, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Juvenile pol)35(yposis: mas)]TJ 0 Tw (-)Tj 0.101 Tw -1.796 -1.25 Td [(si)-16(ve gastr)-36.9(ic pol)35(yposis is mor)-24(e common in MADH4 mut)15(a)15(t)-32(ion car)-24(r)-37(ier)-9.9(s )]TJ -0.025 Tw T* [(t)-13(han in BMPR1A mut)15(a)15(t)-32(ion car)-24(r)-37(ier)-9.9(s. )]TJ /T1_1 1 Tf (Hum Genet.)Tj /T1_0 1 Tf ( 2002 Jul;111\(1\):108\226)Tj 0.023 Tw T* [(11. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1007/s00439-002-0748-9)Tj 0 0 0 1 k /GS1 gs 0.108 Tw T* (34.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Gall)-31(ione)]TJ /Span<>> BDC ( )Tj EMC [(CJ, R)13(epe)-11.9(t)-30(t)17(o)]TJ /Span<>> BDC ( )Tj EMC [(GM, L)35(egius)]TJ /Span<>> BDC ( )Tj EMC [(E, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. A combined syndr)-32(ome )]TJ 0.255 Tw -1.796 -1.25 Td [(of juvenile pol)35(yposis and her)-24(edi)-23.9(t)15(ar)-24(y haemor)-24(r)-24(ha)-17(gic tel)-15.9(angiec)-16(t)15(asia )]TJ 0.227 Tw T* [(asso)-16(c)-24(ia)15.1(ted wi)-24(t)-13(h mut)15(a)15(t)-32(ions in MADH4 \(SMAD4\). )]TJ /T1_1 1 Tf 0 Tw (Lancet)Tj /T1_0 1 Tf 0.227 Tw (. 2004 Mar )Tj 0.023 Tw T* [(13;363\(9412\):852\2269. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1016/S0140-6736\(04\)15732-2)Tj 0 0 0 1 k /GS1 gs 0.232 Tw T* (35.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(O\245Malle)-10.9(y)]TJ /Span<>> BDC ( )Tj EMC [(M, L)-32(aGuar)-23.9(dia)]TJ /Span<>> BDC ( )Tj EMC [(L, K)-16(al)-16(ad)17(y)]TJ /Span<>> BDC ( )Tj EMC [(MF, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. T)47(he p)25(r)-24(ev)-15(alence of )]TJ 0.298 Tw -1.796 -1.25 Td [(her)-24(edi)-23.9(t)15(ar)-24(y hemor)-23.9(r)-24(ha)-17(gic tel)-16(angiec)-16(t)15(asia in juvenile pol)35(yposis syn)]TJ 0 Tw (-)Tj T* [(dr)-32(ome. )]TJ /T1_1 1 Tf 0.226 Tw 3.29 0 Td [(Dis Colon )0.5(R)21(ectum.)]TJ /T1_0 1 Tf [( 2012 A)10(ug;55\(8\):886\22692. )0.5(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1097/)Tj -3.29 -1.25 Td (DCR.0b013e31825aad32)Tj 0 0 0 1 k /GS1 gs -0.032 Tw T* (36.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Angel)Tj /Span<>> BDC ( )Tj EMC [(CM. Her)-24(edi)-24(t)15.1(ar)-24(y Hemor)-24(r)-23.9(ha)-17(gic T)40(el)-15.9(angiec)-16(t)15(asia: Dia)-17(gnosis and )]TJ 0 Tw -1.796 -1.25 Td [(Mana)-17(gement. )]TJ /T1_1 1 Tf 0.129 Tw 5.813 0 Td (J Clin Med. )Tj /T1_0 1 Tf [(2022 A)10(ug 11;11\(16\):4698. )0.5(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.3390/)Tj -5.813 -1.25 Td (jcm11164698)Tj 0 0 0 1 k /GS1 gs 0.066 Tw T* (37.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(L)-32(in)]TJ /Span<>> BDC ( )Tj EMC [(AE, Micho)17(t)]TJ /Span<>> BDC ( )Tj EMC [(C, Cor)-15.9(mier-Dair)-24(e)]TJ /Span<>> BDC ( )Tj EMC [(V, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Gain-of-func)-15.9(t)-32(ion mut)15(a)]TJ 0 Tw (-)Tj 0.031 Tw -1.796 -1.25 Td [(t)-32(ions in SMAD4 cause a dist)-31.9(inc)-16(t)-32(i)-16(ve r)-23.9(eper)-22(t)17(oir)-24(e of car)-23.9(diov)-15(ascul)-16(ar phe)]TJ 0 Tw (-)Tj 0.094 Tw T* [(no)17(t)-10(ypes in p)32(a)15(t)-32(ients wi)-23.9(t)-13(h M)16(yhr)-23.9(e syndr)-32(ome. )]TJ /T1_1 1 Tf (Am J Med Genet)Tj /Span<>> BDC ( )Tj EMC (A)Tj /T1_0 1 Tf (. 2016 )Tj 0.023 Tw 29.055 81.25 Td [(O)-16(c)-16(t;170\(10\):2617\22631. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1002/ajmg.a.37739)Tj 0 0 0 1 k /GS1 gs 0.003 Tw T* (38.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Zhao)Tj /Span<>> BDC ( )Tj EMC [(ZY, L)35(ei)]TJ /Span<>> BDC ( )Tj EMC [(Y, W)12(ang)]TJ /Span<>> BDC ( )Tj EMC [(ZM, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. R)13(e-r)-24(eco)-16(gni)-24(t)-31.9(ion of )]TJ /T1_1 1 Tf 0 Tw [(BMP)66(R1A)]TJ /T1_0 1 Tf [(-r)-24(el)-16(a)15(ted )]TJ 0.344 Tw -1.796 -1.25 Td [(pol)35(yposis: )0.6(be)-11(yond )0.6(juvenile )0.6(pol)35(yposis )0.6(and )0.5(her)-23.9(edi)-24(t)15(ar)-24(y )0.6(mix)12(ed )0.5(pol)]TJ 0 Tw (-)Tj 0.14 Tw T* [(yposis syndr)-31.9(ome. )]TJ /T1_1 1 Tf [(Gastroenterol R)21(ep \(Oxf\). )]TJ /T1_0 1 Tf [(2023 Jan 5;11:goa)-17(c082. )]TJ 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td [(10.1093/gastr)-31.9(o/goa)-17(c082)]TJ 0 0 0 1 k /GS1 gs 0.161 Tw -1.847 -1.25 Td (39.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(O\245R)-24(ior)-23.9(d)41.9(an)]TJ /Span<>> BDC ( )Tj EMC [(JM, O\245Dono)-16(ghue)]TJ /Span<>> BDC ( )Tj EMC [(D, G)20(r)-24(een)]TJ /Span<>> BDC ( )Tj EMC [(A, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Her)-23.9(edi)-24(t)15(ar)-24(y mix)12(ed )]TJ 0.055 Tw -1.796 -1.25 Td [(pol)35(yposis syndr)-32(ome due t)17(o a BMPR1A mut)15(a)15(t)-32(ion. )]TJ /T1_1 1 Tf (Colorectal Dis. )Tj /T1_0 1 Tf 0 Tw (2010 )Tj 0.023 Tw T* [(Jun;12\(6\):570\2263. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1111/j.1463-1318.2009.01931.x)Tj 0 0 0 1 k /GS1 gs 0.169 Tw T* (40.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Cao)Tj /Span<>> BDC ( )Tj EMC (X, Eu)Tj /Span<>> BDC ( )Tj EMC [(KW, K)25(umar)-32.9(asinghe)]TJ /Span<>> BDC ( )Tj EMC [(MP, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Mapping of her)-23.9(edi)-24(t)15(ar)-23.9(y )]TJ -0.014 Tw -1.796 -1.25 Td [(mix)12(ed pol)35(yposis syndr)-32(ome \(HMPS\) t)17(o chr)-32(omosome 10q23 b)11.9(y genome)]TJ 0 Tw (-)Tj 0.149 Tw T* [(wide high-densi)-23.9(t)-10(y single nucleo)17(t)-32(ide pol)35(ymor)-24(phis)26(m \(SNP\) scan and )]TJ 0.35 Tw T* [(ident)-32.1(if)-28.1(ica)14.8(t)-32.2(ion of BMPR1A l)29.8(oss of func)-16.1(t)-32.2(ion. )]TJ /T1_1 1 Tf (J Med Genet)Tj /T1_0 1 Tf (. 2006 )Tj 0.023 Tw T* [(Mar;43\(3\):e13. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1136/jmg.2005.034827)Tj 0 0 0 1 k /GS1 gs 0.012 Tc 0.446 Tw T* (41.)Tj /Span<>> BDC ( )Tj EMC 1.844 0 Td [(Cho)-14.1(w)]TJ /Span<>> BDC ( )Tj EMC 2.869 0 Td [(E, Ma)-17(cr)-33(ae)]TJ /Span<>> BDC ( )Tj EMC [(F. A r)-24.1(ev)-16.1(iew of )0.5(juvenile pol)35(yposis syn)]TJ 0 Tc 0 Tw (-)Tj 0.016 Tc -0.016 Tw -4.713 -1.25 Td [(dr)-32.2(ome. )]TJ /T1_1 1 Tf 0.593 Tw 3.771 0 Td (J Gastroenterol Hepatol. )Tj /T1_0 1 Tf [(2005 N)-14.2(ov;20\(11\):1634\22640.)16( )]TJ 0 Tc 0 Tw -3.771 -1.25 Td [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1111/j.1440-1746.2005.03865.x)Tj 0 0 0 1 k /GS1 gs 0.082 Tw -1.847 -1.25 Td (42.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (\037\031\022\026\027\024\r)Tj /Span<>> BDC ( )Tj EMC (\202.\221. \221\021\030\026\021\036\020\017\016 \022\024\n\023\035\036\022\ \f\027\024\020\024 \n\024\035\036\022\031\035\016\030\027\024-\020\036\027\ \036\021\017\004\036)Tj 0 Tw (-)Tj -0.021 Tw -1.796 -1.25 Td (\f\022\024\020\024 \017\031\004\036\027\017\016 \027\026\f\035\036\007\f\ \021\r\036\027\027\t\b \235\024\030\n \022\024\035\024\030\036\022\021\026\ \035\034\027\024\020\024 \030\026\022\026 \031)Tj /Span<>> BDC ( )Tj EMC (\030\024\f)Tj 0 Tw (-)Tj 0.114 Tw T* [(\f\017\005\f\022\017\b \023\026\006\017\036\027\021\024\r \(\026\r\021\024\ \030\036\235. )0.5(\246 \007-\030\026. \n\036\007. \027\026\031\022\). \204\024\f\022\r\026\ . 2017; )]TJ -0.029 Tw T* (48)Tj /Span<>> BDC ( )Tj EMC [(\f. / T)60(suk)-16.9(anov)]TJ /Span<>> BDC ( )Tj EMC [(A.S. S)15(tr)-32.9(a)15(teg)16(y of com)10(ple)-18(x molecul)-15.9(ar gene)-11.9(t)-32(ics stud)17(y of )]TJ 0.089 Tw T* [(her)-24(edi)-23.9(t)15(ar)-24(y for)-16(ms of col)30(or)-24(ec)-15.9(t)15(al cancer in Russian p)32(a)15(t)-32(ients \(abstr)-33(a)-17(c)-16(t. )]TJ 0.023 Tw T* [(\246 d)-16(o)-16(c)-16(t)17.1(or of medical sc)-23.9(iences\). M)-24(osco)-13.9(w. 2017; 48 \030. \(in Russ.\).)]TJ 0.302 Tw T* (43.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Br)-32(osens)]TJ /Span<>> BDC ( )Tj EMC [(L)-34.9(A, v)-15(an Ha)15(t)-30(tem)]TJ /Span<>> BDC ( )Tj EMC [(A, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. R)-24(isk of col)30(or)-23.9(ec)-16(t)15(al cancer )]TJ 0.294 Tw -1.796 -1.25 Td [(in juvenile pol)35(yposis. )]TJ /T1_1 1 Tf 0 Tw 9.636 0 Td (Gut)Tj /T1_0 1 Tf 0.294 Tw [(. )0.5(2007 Jul;56\(7\):965\2267. )0.5(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1136/)Tj -9.636 -1.25 Td (gut.2006.116913)Tj 0 0 0 1 k /GS1 gs 0.267 Tw T* (44.)Tj /Span<>> BDC ( )Tj EMC [(L)-32(a)15(tchfor)-23.9(d)]TJ /Span<>> BDC ( )Tj EMC (AR, Neale)Tj /Span<>> BDC ( )Tj EMC [(K, Phill)-30.9(ips)]TJ /Span<>> BDC ( )Tj EMC [(RK, e)-11.9(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Juvenile pol)35.1(yposis )]TJ 0.321 Tw T* [(syndr)-32(ome: a stud)17(y of geno)17(t)-10(ype, pheno)17(t)-10(ype, and l)30(ong-ter)-15.9(m out)]TJ 0 Tw (-)Tj T* (come. )Tj /T1_1 1 Tf 0.168 Tw 2.822 0 Td [(Dis Colon R)21(ectum.)]TJ /T1_0 1 Tf [( 2012 O)-16(c)-15.9(t;55\(10\):1038\22643. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1097/)Tj -2.822 -1.25 Td (DCR.0b013e31826278b3)Tj 0 0 0 1 k /GS1 gs 0.012 Tc 0.446 Tw T* (45.)Tj /Span<>> BDC ( )Tj EMC 1.844 0 Td [(K)-16.1(a)15(t)14.9(aba)14.9(t)-13.1(hina)]TJ /Span<>> BDC ( )Tj EMC [(V)27(S, Menias)]TJ /Span<>> BDC ( )Tj EMC [(C)13(O, Khanna)]TJ /Span<>> BDC ( )Tj EMC [(L, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Her)-24(edi)-24(t)14.9(ar)-24(y)12( )]TJ 0.021 Tc 0.766 Tw -1.844 -1.25 Td [(Gastr)-32.2(ointest)-32.2(inal Cancer Syndr)-32.2(omes: R)10.8(ole of Ima)-17.2(ging in)21( )]TJ 0 Tc 0.25 Tw T* [(S)-24(cr)-23.9(eening, Dia)-17(gnosis, and Mana)-17(gement. )]TJ /T1_1 1 Tf 0 Tw [(R)19.9(adiog)14.1(raphics)]TJ /T1_0 1 Tf 0.25 Tw (. 2019 Sep-)Tj 0.023 Tw T* [(O)-16(c)-16(t;39\(5\):1280\2261301. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw [(10.1148/r)-32(g.2019180185)]TJ 0 0 0 1 k /GS1 gs 0.244 Tw T* (46.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(R)13(eichel)56(t)]TJ /Span<>> BDC ( )Tj EMC (U, Hopfer)Tj /Span<>> BDC ( )Tj EMC [(H, R)11(o)-16(ch)]TJ /Span<>> BDC ( )Tj EMC [(N, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Juvenile pol)35(yposis col)-31(i: )]TJ 0.338 Tw -1.796 -1.25 Td [(a )0.5(f)16(a)-16.9(cul)56(t)15(a)15(t)-32(i)-16(ve )0.5(p)25(r)-23.9(ecancer)-32(osis )0.6(wi)-24(t)-13(h )0.6(some )0.5(simil)-16(ar)-36.9(i)-24(t)-32(ies )0.6(t)17(o )0.5(ul)16(cer)-33(a)15(t)-32(i)-15.9(ve )]TJ 0.006 Tc -0.006 Tw T* [(col)-30.6(i)-23.5(t)-31.6(is? )]TJ /T1_1 1 Tf 0.349 Tw 3.641 0 Td [(P)18.4(athol R)21.4(es Pr)0.5(act.)]TJ /T1_0 1 Tf [( 200)0.5(5;)0.5(201\(7\):517\22620. d)-15.6(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs -0.006 Tw [(10.1016)0.5(/j.)]TJ 0 Tc 0 Tw -3.641 -1.25 Td [(p)25(r)-24(p.2005.05.001)]TJ 0 0 0 1 k /GS1 gs 0.246 Tw T* (47.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Cone)Tj /Span<>> BDC ( )Tj EMC [(MM. Hamar)-22(t)17(oma)15(t)17(ous P)10(ol)35(yps and Asso)-15.9(c)-24(ia)15(ted Syndr)-32(omes. )]TJ /T1_1 1 Tf 0.247 Tw -1.796 -1.25 Td [(Clin Colon R)21.1(ectal Surg. )]TJ /T1_0 1 Tf [(2016 Dec;29\(4\):330\226335. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1055/s-)Tj T* (0036-1582441)Tj 0 0 0 1 k /GS1 gs 0.031 Tw T* (48.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Subr)-33(amony)]TJ /Span<>> BDC ( )Tj EMC [(C, S)-24(co)17.1(t)-30(t-Conner)]TJ /Span<>> BDC ( )Tj EMC [(CE, S)-16(k)10(el)56(t)17(on)]TJ /Span<>> BDC ( )Tj EMC [(D, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. F)20(amil)-30.9(ial juvenile )]TJ -0.003 Tw -1.796 -1.25 Td [(pol)35(yposis. S)15(tud)17(y of a k)-16(indr)-23.9(ed: evol)35(ut)-32(ion of pol)35(yps and r)-24(el)-16(a)15(t)-32(ionship t)17.1(o )]TJ 0.02 Tw T* [(gastr)-32(ointest)-31.9(inal car)-31.9(c)-24(inoma. )]TJ /T1_1 1 Tf [(Am J Clin P)18(athol. )]TJ /T1_0 1 Tf (1994 Jul;102\(1\):91\2267. )Tj 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1093/ajcp/102.1.91)Tj 0 0 0 1 k /GS1 gs -0.038 Tw -1.847 -1.25 Td (49.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(T)40(anak)-17(a)]TJ /Span<>> BDC ( )Tj EMC 2.987 0 Td [(T. )0.5(Col)30(or)-24(ec)-15.9(t)15(al )0.5(car)-32(c)-24(ino)-16(genesis: )0.5(R)13(ev)-16(iew )0.5(of )0.5(human )0.5(and )0.5(e)-18(xper)]TJ 0 Tw 22.502 0 Td (-)Tj 0.202 Tw -27.286 -1.25 Td [(iment)15(al animal studies. )]TJ /T1_1 1 Tf (J Carcinog.)Tj /T1_0 1 Tf [( 2009;8:5. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.4103/1477-)Tj T* (3163.49014)Tj 0 0 0 1 k /GS1 gs 0.169 Tw T* (50.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Jelsig)Tj /Span<>> BDC ( )Tj EMC [(AM. Hamar)-21.9(t)17(oma)15(t)17(ous pol)35(yps)]TJ /Span<>> BDC ( )Tj EMC [(\227 a cl)-30.9(inical and molecul)-16(ar )]TJ 0.023 Tw -1.796 -1.25 Td [(gene)-12(t)-32(ic stud)17(y. )]TJ /T1_1 1 Tf (Dan Med)Tj /Span<>> BDC ( )Tj EMC (J.)Tj /T1_0 1 Tf [( 2016 A)10(ug;63\(8\):B5280.)]TJ 0.299 Tw T* (51.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Hir)-32(o)17(t)15(ani)]TJ /Span<>> BDC ( )Tj EMC [(A, Sak)-17(ai)]TJ /Span<>> BDC ( )Tj EMC [(E, Nak)-17(ajima)]TJ /Span<>> BDC ( )Tj EMC [(A, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. End)-16(oscopic f)-28(indings )]TJ 0.01 Tc 0.38 Tw -1.796 -1.25 Td [(of a)14.8(t)-10.2(ypical juvenile col)29.8(onic pol)34.8(yps. )]TJ /T1_1 1 Tf (Gastrointest Endosc.)Tj /T1_0 1 Tf [( 2016)10( )]TJ 0 Tc 0.023 Tw T* [(F)10(eb;83\(2\):476\2267; discussion 477. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1016/j.gie.2015.08.032)Tj 0 0 0 1 k /GS1 gs 0.034 Tw T* (52.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Dong)Tj /Span<>> BDC ( )Tj EMC (J, Ma)Tj /Span<>> BDC ( )Tj EMC [(T)25(S, Xu)]TJ /Span<>> BDC ( )Tj EMC [(YH, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Char)-33(a)-17(c)-15.9(ter)-37(ist)-32(ics and po)17(tent)-32(ial mal)-31(ig)]TJ 0 Tw (-)Tj 0.099 Tw -1.796 -1.25 Td [(nancy of col)30(or)-24(ec)-16(t)15(al juvenile pol)35(yps in adul)56(ts: a single-center r)-23.9(e)-12(tr)-32(o)]TJ 0 Tw (-)Tj 0.143 Tw T* [(spec)-16(t)-32(i)-15.9(ve stud)17(y in China. )]TJ /T1_1 1 Tf (BMC Gastroenterol)Tj /T1_0 1 Tf [(. 2022 F)10(eb 21;22\(1\):75. )]TJ 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1186/s12876-022-02151-x)Tj 0 0 0 1 k /GS1 gs -0.035 Tw -1.847 -1.25 Td (53.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(R)-24(icc)-24(i)]TJ /Span<>> BDC ( )Tj EMC (MT, Salemme)Tj /Span<>> BDC ( )Tj EMC [(M, V)-15.1(ill)-15.9(ana)-17(cc)-24(i)]TJ /Span<>> BDC ( )Tj EMC [(V, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. T)47(he gene)-12(t)-32(ics of inher)-37(i)-24(ted )]TJ 0.206 Tw -1.796 -1.25 Td [(p)25(r)-24(edisposi)-23.9(t)-32(ions t)17(o col)30(or)-23.9(ec)-16(t)15(al pol)35(yps: a quick guide for cl)-31(inic)-24(ians. )]TJ /T1_1 1 Tf 0.023 Tw T* (Colorectal Dis.)Tj /T1_0 1 Tf [( 2015 Jan;17Suppl 1:3\2269. d)-15.9(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1111/codi.12814)Tj 0 0 0 1 k /GS1 gs 0.193 Tw T* (54.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(R)11(osner)]TJ /Span<>> BDC ( )Tj EMC [(G, P)30(e)-12(tel-Gal)-30.9(il)]TJ /Span<>> BDC ( )Tj EMC [(Y, L)-32(aish)]TJ /Span<>> BDC ( )Tj EMC [(I, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. A)15.1(denoma)15(t)17(ous P)10(ol)35(yposis )]TJ 0.006 Tc 0.35 Tw -1.796 -1.25 Td [(Pheno)16.8(t)-10.3(ype in BMPR1A and SMAD4 V)24.7(ar)-37.2(iant Car)-24.3(r)-37.2(ier)-10.3(s. )]TJ /T1_1 1 Tf [(Clin T)55.7(ransl)6( )]TJ 0.02 Tc -0.02 Tw T* [(Ga)0.5(stro)0.5(enter)0.5(ol.)]TJ /T1_0 1 Tf 0.709 Tw [( 202)0.5(2 O)-15.5(c)-15.6(t 1;13)0.5(\(10\):)0.5(e00527)0.5(. d)-15.5(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs -0.02 Tw [(10.)0.5(14309/)]TJ 0 Tc 0 Tw T* [(c)-16(tg.0000000000000527)]TJ 0 0 0 1 k /GS1 gs 0.029 Tw T* (55.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(P)20(u LZ)46(CT, Cheong)]TJ /Span<>> BDC ( )Tj EMC [(KL, K)25(oa)15(y)]TJ /Span<>> BDC ( )Tj EMC [(DSC, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. R)-10(and)-16(omised contr)-32(olled tr)-37(ial )]TJ 0.114 Tw -1.796 -1.25 Td [(com)10(p)32(ar)-37(ing modif)-28(ied Sano\245s and nar)-24(r)-32(o)-13.9(w band ima)-17(ging inter)-14.9(na)15(t)-32(ional )]TJ 0.251 Tw T* [(col)30(or)-24(ec)-15.9(t)15(al end)-16(oscopic cl)-16(assif)-27.9(ica)15(t)-32(ions for col)30(or)-24(ec)-16(t)15(al lesions. )]TJ /T1_1 1 Tf 0 Tw [(W)29(orld )]TJ 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\214)10(\211\036\033 \035\030\032\t\033)30(\b)42(\032)-21(\240\033\233)]TJ 57.136 0 Td (REVIEW)Tj -57.136 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 23, \023\0221)69(, 202)69(4)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 23, \023\0221)69(, 202)69(4)]TJ /T1_3 1 Tf 25 0 0 25 20.7153 56.0378 Tm (150)Tj ET endstream endobj 779 0 obj <>/Border[0 0 0]/H/N/Rect[243.241 728.512 291.968 719.056]/Subtype/Link/Type/Annot>> endobj 780 0 obj <>/Border[0 0 0]/H/N/Rect[70.8661 718.512 142.698 709.216]/Subtype/Link/Type/Annot>> endobj 781 0 obj <>/Border[0 0 0]/H/N/Rect[191.844 698.512 252.86 689.056]/Subtype/Link/Type/Annot>> endobj 782 0 obj <>/Border[0 0 0]/H/N/Rect[243.577 678.512 291.968 669.056]/Subtype/Link/Type/Annot>> endobj 783 0 obj <>/Border[0 0 0]/H/N/Rect[70.8661 668.512 108.506 659.216]/Subtype/Link/Type/Annot>> endobj 784 0 obj <>/Border[0 0 0]/H/N/Rect[238.641 648.512 291.968 639.056]/Subtype/Link/Type/Annot>> endobj 785 0 obj <>/Border[0 0 0]/H/N/Rect[70.8661 638.512 133.522 629.216]/Subtype/Link/Type/Annot>> endobj 786 0 obj <>/Border[0 0 0]/H/N/Rect[102.062 608.512 174.278 599.216]/Subtype/Link/Type/Annot>> endobj 787 0 obj <>/Border[0 0 0]/H/N/Rect[151.366 578.512 256.83 569.216]/Subtype/Link/Type/Annot>> endobj 788 0 obj <>/Border[0 0 0]/H/N/Rect[152.302 538.512 220.462 529.216]/Subtype/Link/Type/Annot>> endobj 789 0 obj <>/Border[0 0 0]/H/N/Rect[152.966 508.512 245.79 499.216]/Subtype/Link/Type/Annot>> endobj 790 0 obj <>/Border[0 0 0]/H/N/Rect[98.0624 478.512 185.158 469.216]/Subtype/Link/Type/Annot>> endobj 791 0 obj <>/Border[0 0 0]/H/N/Rect[85.6442 448.512 187.556 439.216]/Subtype/Link/Type/Annot>> endobj 792 0 obj <>/Border[0 0 0]/H/N/Rect[156.35 418.512 261.814 409.216]/Subtype/Link/Type/Annot>> endobj 793 0 obj <>/Border[0 0 0]/H/N/Rect[153.19 368.512 207.102 359.216]/Subtype/Link/Type/Annot>> endobj 794 0 obj <>/Border[0 0 0]/H/N/Rect[149.662 338.512 246.837 329.216]/Subtype/Link/Type/Annot>> endobj 795 0 obj <>/Border[0 0 0]/H/N/Rect[149.662 298.512 236.309 289.216]/Subtype/Link/Type/Annot>> endobj 796 0 obj <>/Border[0 0 0]/H/N/Rect[205.479 268.512 279.534 259.056]/Subtype/Link/Type/Annot>> endobj 797 0 obj <>/Border[0 0 0]/H/N/Rect[98.0624 228.512 191.534 219.216]/Subtype/Link/Type/Annot>> endobj 798 0 obj <>/Border[0 0 0]/H/N/Rect[157.286 188.512 266.454 179.216]/Subtype/Link/Type/Annot>> endobj 799 0 obj <>/Border[0 0 0]/H/N/Rect[262.057 158.512 291.968 149.056]/Subtype/Link/Type/Annot>> endobj 800 0 obj <>/Border[0 0 0]/H/N/Rect[70.8661 148.512 148.778 139.216]/Subtype/Link/Type/Annot>> endobj 801 0 obj <>/Border[0 0 0]/H/N/Rect[262.057 128.512 291.968 119.056]/Subtype/Link/Type/Annot>> endobj 802 0 obj <>/Border[0 0 0]/H/N/Rect[70.8661 118.512 114.362 109.216]/Subtype/Link/Type/Annot>> endobj 803 0 obj <>/Border[0 0 0]/H/N/Rect[392.743 738.512 466.798 729.216]/Subtype/Link/Type/Annot>> endobj 804 0 obj <>/Border[0 0 0]/H/N/Rect[318.085 698.512 399.285 689.216]/Subtype/Link/Type/Annot>> endobj 805 0 obj <>/Border[0 0 0]/H/N/Rect[377.631 668.512 493.614 659.216]/Subtype/Link/Type/Annot>> endobj 806 0 obj <>/Border[0 0 0]/H/N/Rect[368.575 618.512 455.222 609.216]/Subtype/Link/Type/Annot>> endobj 807 0 obj <>/Border[0 0 0]/H/N/Rect[318.085 588.512 434.068 579.216]/Subtype/Link/Type/Annot>> endobj 808 0 obj <>/Border[0 0 0]/H/N/Rect[494.498 508.512 524.409 499.056]/Subtype/Link/Type/Annot>> endobj 809 0 obj <>/Border[0 0 0]/H/N/Rect[303.307 498.512 359.003 489.216]/Subtype/Link/Type/Annot>> endobj 810 0 obj <>/Border[0 0 0]/H/N/Rect[494.498 468.512 524.409 459.056]/Subtype/Link/Type/Annot>> endobj 811 0 obj <>/Border[0 0 0]/H/N/Rect[303.307 458.512 381.811 449.216]/Subtype/Link/Type/Annot>> endobj 812 0 obj <>/Border[0 0 0]/H/N/Rect[392.743 418.512 471.799 409.216]/Subtype/Link/Type/Annot>> endobj 813 0 obj <>/Border[0 0 0]/H/N/Rect[489.495 388.512 524.409 379.056]/Subtype/Link/Type/Annot>> endobj 814 0 obj <>/Border[0 0 0]/H/N/Rect[303.307 378.512 356.955 369.216]/Subtype/Link/Type/Annot>> endobj 815 0 obj <>/Border[0 0 0]/H/N/Rect[488.57 358.512 524.409 349.056]/Subtype/Link/Type/Annot>> endobj 816 0 obj <>/Border[0 0 0]/H/N/Rect[303.307 348.512 350.123 339.216]/Subtype/Link/Type/Annot>> endobj 817 0 obj <>/Border[0 0 0]/H/N/Rect[318.085 308.512 393.725 299.216]/Subtype/Link/Type/Annot>> endobj 818 0 obj <>/Border[0 0 0]/H/N/Rect[475.682 288.512 524.409 279.056]/Subtype/Link/Type/Annot>> endobj 819 0 obj <>/Border[0 0 0]/H/N/Rect[303.307 278.512 341.675 269.216]/Subtype/Link/Type/Annot>> endobj 820 0 obj <>/Border[0 0 0]/H/N/Rect[428.971 228.512 516.555 219.216]/Subtype/Link/Type/Annot>> endobj 821 0 obj <>/Border[0 0 0]/H/N/Rect[318.085 188.512 415.109 179.216]/Subtype/Link/Type/Annot>> endobj 822 0 obj <>/Border[0 0 0]/H/N/Rect[448.119 158.512 514.127 149.056]/Subtype/Link/Type/Annot>> endobj 823 0 obj <>/Border[0 0 0]/H/N/Rect[489.244 128.512 524.409 119.056]/Subtype/Link/Type/Annot>> endobj 824 0 obj <>/Border[0 0 0]/H/N/Rect[303.307 118.512 380.115 109.216]/Subtype/Link/Type/Annot>> endobj 870 0 obj <> endobj 869 0 obj <> endobj 868 0 obj <> endobj 867 0 obj <> endobj 866 0 obj <> endobj 865 0 obj <> endobj 864 0 obj <> endobj 863 0 obj <> endobj 862 0 obj <> endobj 861 0 obj <> endobj 860 0 obj <> endobj 859 0 obj <> endobj 858 0 obj <> endobj 857 0 obj <> endobj 856 0 obj <> endobj 855 0 obj <> endobj 854 0 obj <> endobj 853 0 obj <> endobj 852 0 obj <> endobj 851 0 obj <> endobj 850 0 obj <> endobj 849 0 obj <> endobj 848 0 obj <> endobj 847 0 obj <> endobj 846 0 obj <> endobj 845 0 obj <> endobj 844 0 obj <> endobj 843 0 obj <> endobj 842 0 obj <> endobj 841 0 obj <> endobj 840 0 obj <> endobj 839 0 obj <> endobj 838 0 obj <> endobj 837 0 obj <> endobj 836 0 obj <> endobj 835 0 obj <> endobj 834 0 obj <> endobj 833 0 obj <> endobj 832 0 obj <> endobj 831 0 obj <> endobj 830 0 obj <> endobj 829 0 obj <> endobj 828 0 obj <> endobj 827 0 obj <> endobj 826 0 obj <> endobj 825 0 obj <> endobj 775 0 obj [871 0 R 872 0 R 873 0 R 874 0 R 875 0 R 876 0 R 877 0 R 878 0 R 879 0 R 880 0 R 881 0 R 882 0 R 883 0 R 884 0 R 885 0 R 886 0 R 887 0 R 888 0 R 889 0 R 890 0 R 891 0 R] endobj 776 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\021\220\001\201\002\025\024 \212\r\016\001\220\007\216\001\025\202)10(\025 \221\025\007\220\221\025)21(\222\013 \(\025\f\222\025\002 \007\220\026)11(\016\002\013\026)-20(\215\002\020\))]TJ 45.723 0 Td [(Ju)10(v)12(enile polyposis s)10(yndr)20(ome \(r)31(e)11(vie)11(w\))]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0.068 Tw 10 0 0 10 42.5197 724.8299 Tm (\023\031\035\034\f\024\022\f\017\n\036\021\030\017\017 \017)Tj /Span<>> BDC ( )Tj EMC (\021\030\026\027\f\021\024\030\026\022\026\035\034\027\024\005 \220\b\024\ \022\026\030\007\017\024\020\030\026)Tj 0 Tw (-)Tj 0 -1.218 TD (\235\017\017 [79].)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 42.5896 676.1179 Tm [(\020)21(\026\027\r\242\224\034\022\031\034)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0 Tc 0.335 Tw 10 0 0 10 42.5197 651.7618 Tm (\211\004\017\021\t\r\026\016 \022\030\026\005\027\036 \030\036\007\022\031\ \033 \r\f\021\030\036\004\026\036\n\024\f\021\034 \f\017\027\007\030\024\ \n\026 )Tj 0.582 Tw T* [(\033\r\036\027\017\035\034\027\024\020\024 )0.6(\023\024\035\017\023\024\026, )0.5(\030\026\027\024\024\002\030\026\027\t\036 )0.6(\027\036\f\023\036\006\017)]TJ /Span<>> BDC (-)Tj EMC 0.87 Tw T* (\235\017\004\036\f\022\017\036 \022\035\017\027\017\004\036\f\022\017\036\ \023\030\024\016\r\035\036\027\017\016, \024\021\f\031\021\f\021\r\017\036\ )Tj 0.403 Tw 0 -1.218 TD [(\004\036\021\022\024 )0.5(\030\026\030\026\002\024\021\026\027\027\t\b )0.6(\220\027\007\024\f\022\024\023\017\004\036\f\022\017\b )0.6(\022\030\017\021\036\030\017\036\r, )]TJ 0.365 Tw 0 -1.218 TD (\024\020\030\026\027\017\004\036\027\017\016 \r)Tj /Span<>> BDC ( )Tj EMC (\212\203\025-\007\017\026\020\027\024\f\021\017\022\036 \026\002\024\035\ \036\r\026\027\017\016, \026)Tj 0 Tw (-)Tj 0.244 Tw 0 -1.218 TD [(\004\026\f\021\031\033 )0.6(\r\024\027\017\022\026\033\021 )0.5(\f\035\024\032\027\024\f\021\017 )0.6(\023\030\017)]TJ /Span<>> BDC ( )Tj EMC 15.122 0 Td [(\023\024\f\021\026\027\024\r\022\036 )0.5(\023\030\026)]TJ 0 Tw (-)Tj 0.323 Tw -15.122 -1.218 Td (\r\017\035\034\027\024\020\024 \007\017\026\020\027\024\026, \007\026\027\ \027\t\005 \024\002\024\030 \035\017\021\036\030\026\021\031\030\t \007\ \036)Tj 0 Tw (-)Tj 0.007 Tw T* (\n\024\027\f\021\030\017\030\031\036\021 \027\036\024\002\b\024\007\017\n\ \024\f\021\034 \023\030\024\r\036\007\036\027\017\016 \007\026\035\034\027\ \036\005\001\017\b )Tj 0 Tw T* (\017\f\f\035\036\007\024\r\026\027\017\005.)Tj /T1_3 1 Tf 0.023 Tw 0 -2.436 TD (\223\030\032\255\020\034\036 \032\026\020\017\022\017\026)Tj /T1_1 1 Tf 0.46 Tw 0 -1.218 TD [(\025)-4.1(\024)-4.3(\027)1.7(\006)-6(\036)-6.8(\023)2.2(\006)-6(\017)-5.4(\016 \017)]TJ /Span<>> BDC ( )Tj EMC [(\007)-6(\017)2.7()-9.9(\026\005)1.7(\027 \017)-2.4(\f)3.1(\f)-38.9(\035)-6.8(\036)-19(\007)-4.4(\024)-4.3(\r)-8.9(\026\027)1.7(\017)-5.5(\016)13.8(:)]TJ /T1_4 1 Tf [( \216)12.5(\023)9(\026\t)4(\013)9.8(\n)]TJ /Span<>> BDC ( )Tj EMC [(\220)65(.)7.3(\201)-2.3(.)7.8(, )]TJ 0 Tw T* [(\035)14.6(\025)7.7(\013)-17.8(\205)2.1(\024)4(\n)9.7(\027)]TJ /Span<>> BDC ( )Tj EMC [(\201)-2.2(.)7.3(\201)-2.3(.)7.8(, \037)-30.3(\205)8.8(\013)12.8(\026)4.3(\021)3.8(\n)9.6(\027)]TJ /Span<>> BDC ( )Tj EMC [(\201)-2.3(.)43.7(\207)-2.1(.)7.8(, )8.9(\n)5.3(\021)3.8(\n)2.4(\003)6.9(\026)1.8(\032\031)2.3(\021)10.7(\013)9.9(\n)]TJ /Span<>> BDC ( )Tj EMC [(\201)-2.3(.)7.3(\201)-2.3(.)]TJ /T1_1 1 Tf T* [(\221)-4.6(\002)-9.9(\024)0.7(\030 \017)]TJ /Span<>> BDC ( )Tj EMC [(\024)-11.8(\002)3(\030)-11.3(\026)-6.4(\002)-9.8(\024)-10.9(\021)-17.7(\022)-19.1(\026 \n)1.3(\026)-11.8(\021)-9.9(\036)-1.7(\030)-7.6(\017)-0.6(\026)-33.1(\035)-2.5(\024)-4.3(\r)10.4(:)]TJ /T1_4 1 Tf [( \216)12.6(\023)9(\026\t)4(\013)9.8(\n)]TJ /Span<>> BDC ( )Tj EMC [(\220)65(.)7.4(\201)-2.3(.)]TJ /T1_1 1 Tf 0.002 Tc -0.002 Tw T* [(\203)7.2(\026\023)4.2(\017\f)-10.8(\026)1.7(\027)3.7(\017)-6.7(\036)2.1( \021)-7.9(\036)-3.4(\022\f)-34(\021)-19.5(\026)5.7(:)]TJ /T1_4 1 Tf 0 Tc 0 Tw 7.694 0 Td [( \216)12.5(\023)9(\026\t)4(\013)9.9(\n)]TJ /Span<>> BDC ( )Tj EMC [(\220)65(.)7.3(\201)-2.3(.)]TJ /T1_1 1 Tf -7.694 -1.218 Td [(\217)5.5(\036)-19(\007)-20.1(\026\022)-32.6(\021)-17.7(\017)1.5(\030)-11.8(\024)-4.4(\r)-8.8(\026\027)1.8(\017)-8.7(\036)6.5(:)]TJ /T1_4 1 Tf 0.882 Tw [( \035)14.6(\025)7.7(\013)-17.8(\205)2.1(\024)4(\n)9.6(\027)]TJ /Span<>> BDC ( )Tj EMC [(\201)-2.3(.)7.4(\201)-2.3(.)7.8(, \216)8.8(\031)-1.4(\t)9.8(\031)-20.6(\023)3.3(\n)9.6(\027)]TJ /Span<>> BDC ( )Tj EMC [(\216)24.4(.)28.5(\216)24.3(.)7.8(, )]TJ 0 Tw T* [(\037)-30.3(\205)8.8(\013)12.7(\026)4.3(\021)3.8(\n)9.7(\027)]TJ /Span<>> BDC ( )Tj EMC [(\201)-2.3(.)43.7(\207)-2.1(.)7.8(, )8.8(\n)5.3(\021)3.9(\n)2.4(\003)6.9(\026)1.8(\032\031)2.3(\021)10.7(\013)9.8(\n)]TJ /Span<>> BDC ( )Tj EMC [(\201)-2.2(.)7.3(\201)-2.3(.)]TJ /T1_3 1 Tf 0.023 Tw 23.244 26.792 Td (AUTHORS CONTRIBUTION)Tj /T1_1 1 Tf 0.178 Tw 0 -1.218 TD [(C)-6.5(o)0.8(nce)-0.7(p)-12.3(t a)2.4(n)-4.6(d d)-5.5(e)-13.3(s)-16.6(i)3.2(g)1.2(n o)-2.2(f t)-16.7(h)-5.3(e s)-20(t)-12.8(ud)-10.9(y)-11.8(:)]TJ /T1_4 1 Tf [( T)49.7(a)-4.9(t)-30(y)3.8(a)-0.8(n)4.8(a)]TJ /Span<>> BDC ( )Tj EMC [(A)-12.5(.)]TJ /Span<>> BDC ( )Tj EMC [(V)0.8(l)3.3(a)-3(s)9.1(k)12.9(o)-3.7(, )]TJ 1.511 Tw 0 -1.218 TD [(A)3.6(l)4.8(e)-28.6(x)2.1(e)-2.5(y)]TJ /Span<>> BDC ( )Tj EMC [(A)-12.6(.)]TJ /Span<>> BDC ( )Tj EMC [(L)3.2(i)7.9(k)12.5(ut)1.4(o)-0.6(v)33.6(, A)3.7(l)4.8(e)-28.6(x)2.1(e)-2.5(y)]TJ /Span<>> BDC ( )Tj EMC [(S)2.2(.)]TJ /Span<>> BDC ( )Tj EMC [(T)50.9(s)11.2(u)4.6(k)15.8(a)-0.8(n)2(o)-0.6(v)33.6(, )]TJ 0 Tw 0 -1.218 TD [(A)3.6(l)4.8(e)-28.6(x)2.1(e)-2.5(y)]TJ /Span<>> BDC ( )Tj EMC [(A)-12.5(.)]TJ /Span<>> BDC ( )Tj EMC [(P)25(on)1.9(om)4.3(ar)2.4(e)-2.5(n)7.5(k)12.9(o)]TJ /T1_1 1 Tf 1.014 Tw 0 -1.218 TD [(C)-6.5(o)-5.8(l)-19(l)-14.3(e)-9.4(c)-32.5(t)-37.3(i)3.2(o)0.8(n )0.5(a)2.4(n)-4.6(d )0.6(p)-3.8(r)-6(o)-7(ce)-13.3(s)-12.8(s)-16.6(i)7.1(n)-1.9(g )0.6(o)-2.2(f )0.5(t)-16.6(h)-5.3(e )0.5(m)1.8(a)-8.4(t)-15.1(e)-2.1(r)-48(i)5.1(a)-1.5(l)-22.5(:)]TJ /T1_4 1 Tf 0 Tw ( )Tj 0 -1.218 TD [(T)49.7(a)-4.9(t)-30(y)3.8(a)-0.8(n)4.8(a)]TJ /Span<>> BDC ( )Tj EMC [(A)-12.6(.)]TJ /Span<>> BDC ( )Tj EMC [(V)0.7(l)3.3(a)-3(s)9.1(k)13(o)]TJ /T1_1 1 Tf T* [(W)3.1(r)-48(i)-6(t)-37.4(i)7.1(n)-1.9(g o)-2.2(f t)-16.7(h)-5.3(e t)-15.2(e)-23.9(x)-36(t)-20(:)]TJ /T1_4 1 Tf [( T)49.7(a)-4.9(t)-30(y)3.8(a)-0.8(n)4.8(a)]TJ /Span<>> BDC ( )Tj EMC [(A)-12.5(.)]TJ /Span<>> BDC ( )Tj EMC [(V)0.7(l)3.3(a)-3(s)9.1(k)12.9(o)]TJ /T1_1 1 Tf 0.006 Tc -0.006 Tw T* [(E)11.6(dit)-31.4(i)13.1(n)4.1(g)15(:)]TJ /T1_4 1 Tf 0 Tc 0.831 Tw 3.238 0 Td [( A)3.6(l)4.8(e)-28.6(x)2.1(e)-2.5(y)]TJ /Span<>> BDC ( )Tj EMC [(A)-12.6(.)]TJ /Span<>> BDC ( )Tj EMC [(L)3.1(i)7.9(k)12.5(ut)1.4(o)-0.6(v)33.6(, V)-5.4(i)7.9(k)-20.8(t)1.4(o)1.3(r)]TJ /Span<>> BDC ( )Tj EMC [(V)53.1(.)]TJ /Span<>> BDC ( )Tj EMC [(V)23(e)-18(s)4.9(e)-1.9(l)2.9(ov)33.6(, )]TJ 0 Tw -3.238 -1.218 Td [(A)3.6(l)4.8(e)-28.6(x)2.1(e)-2.5(y)]TJ /Span<>> BDC ( )Tj EMC [(S)2.1(.)]TJ /Span<>> BDC ( )Tj EMC [(T)50.9(s)11.2(u)4.6(k)15.8(a)-0.8(n)1.9(o)-0.6(v)33.6(, A)3.7(l)4.8(e)-28.6(x)2.1(e)-2.5(y)]TJ /Span<>> BDC ( )Tj EMC [(A)-12.6(.)]TJ /Span<>> BDC ( )Tj EMC [(P)25(o)0.5(n)1.9(om)4.3(ar)2.4(e)-2.6(n)7.5(k)12.9(o)]TJ /T1_3 1 Tf 0.023 Tw 0 -2.436 TD (\255\026\036\031\036\025\034\224 \017\225 \032\026\020\017\022\032\221 \(\ ORCID\))Tj /T1_1 1 Tf 0 Tw 0 -1.218 TD (\200\035\026\f\022\024 \230.\202.)Tj /Span<>> BDC ( )Tj EMC (\227 0000-0003-4533-6555)Tj T* (\214\017\022\031\021\024\r \202.\202.)Tj /Span<>> BDC ( )Tj EMC (\227 0000-0001-5848-4050)Tj T* (\200\036\f\036\035\024\r \200.\200.)Tj /Span<>> BDC ( )Tj EMC (\227 0000-0001-9992-119X)Tj T* (\037\031\022\026\027\024\r \202.\221.)Tj /Span<>> BDC ( )Tj EMC (\227 0000-0001-8571-7462)Tj 0 -1.218 TD (\215\024\027\024\n\026\030\036\027\022\024 \202.\202.)Tj /Span<>> BDC ( )Tj EMC (\227 0000-0001-7203-1859)Tj /T1_3 1 Tf 0.023 Tw 0 -2.436 TD (INFORMATION ABOUT THE AUTHORS \(ORCID\))Tj /T1_1 1 Tf 0 Tw 0 -1.218 TD [(T)40(a)15(t)-10(y)22(ana A. Vl)-15.9(asko)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0003-4533-6555)Tj T* [(Ale)-18(x)12(e)-10.9(y A. L)-32(ikut)17.1(ov)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0001-5848-4050)Tj T* [(V)-15(ik)-24(t)17(or V. V)30.1(esel)30(ov)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0001-9992-119X)Tj T* [(Ale)-18(x)12(e)-10.9(y S. T)60(suk)-17(anov)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0001-8571-7462)Tj T* [(Ale)-18(x)12(e)-10.9(y A. P)10(onomar)-23.9(enko)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0001-7203-1859)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 42.5896 420.3799 Tm [(\r\031\024\034\033)48(\026)45(\024)-10(\223\033)48(\026/REFERENCES)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0 Tc 0.202 Tw 8 0 0 8 42.5197 407.5452 Tm (1.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Ar)-24(e)-11.9(tz)]TJ /Span<>> BDC ( )Tj EMC [(S. T)47(he dif)-56(fer)-24(ent)-31.9(ial dia)-17(gnosis and sur)-32(veill)-15.9(ance of her)-24(edi)]TJ 0 Tw (-)Tj 0.181 Tw -1.296 -1.25 Td [(t)15(ar)-24(y gastr)-31.9(ointest)-32(inal pol)35(yposis syndr)-32(omes. )]TJ /T1_4 1 Tf [(Dtsch Ar)-15.9(ztebl Int. )]TJ /T1_1 1 Tf 0 Tw (2010 )Tj 0.023 Tw 0 -1.25 TD [(Mar;107\(10\):163\22673. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw [(10.3238/ar)-23.9(ztebl.2010.0163)]TJ 0 0 0 1 k /GS1 gs 0.166 Tw T* (2.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (Nielsen)Tj /Span<>> BDC ( )Tj EMC [(M, F)10(r)-33(ank)10.1(en)]TJ /Span<>> BDC ( )Tj EMC [(PF, R)13(einar)-23.9(ds)]TJ /Span<>> BDC ( )Tj EMC [(TH, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Mul)56(t)-32(ipl)-31(ic)-23.9(i)-24(t)-10(y in pol)35(yp )]TJ -0.039 Tw -1.296 -1.25 Td [(count and e)-18(xtr)-33(a)-17(col)30.1(onic manifest)15.1(a)15(t)-32(ions in 40 Dutch p)32(a)15(t)-32(ients wi)-23.9(t)-13(h MYH )]TJ 0.115 Tw T* [(asso)-16(c)-24(ia)15.1(ted pol)35(yposis col)-31(i \(MAP\). )]TJ /T1_4 1 Tf (J Med Genet)Tj /T1_1 1 Tf (. 2005 Sep;42\(9\):e54. )Tj 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1136/jmg.2005.033217)Tj 0 0 0 1 k /GS1 gs 0.003 Tc 0.349 Tw -1.847 -1.25 Td (3.)Tj /Span<>> BDC ( )Tj EMC 1.304 0 Td (Syngal)Tj /Span<>> BDC ( )Tj EMC [(S, Br)-32.8(and)]TJ /Span<>> BDC ( )Tj EMC [(RE, Chur)-31.8(ch)]TJ /Span<>> BDC ( )Tj EMC [(JM, e)-11.7(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Amer)-36.7(ican College of)3( )]TJ 0 Tc 0.093 Tw -1.304 -1.25 Td [(Gastr)-32(oenter)-31.9(ol)30(o)-16(g)16(y. A)16(CG cl)-30.9(inical guidel)-30.9(ine: Gene)-12(t)-32(ic test)-31.9(ing and man)]TJ 0 Tw (-)Tj 0.305 Tw T* [(a)-17(gement of her)-24(edi)-23.9(t)15(ar)-24(y gastr)-32(ointest)-31.9(inal cancer syndr)-32(omes. )]TJ /T1_4 1 Tf (Am J )Tj 0 Tw T* (Gastroenterol.)Tj /T1_1 1 Tf 0.295 Tw [( )0.5(2015 )0.5(F)10(eb;110\(2\):223\22662; )0.5(quiz )0.6(263. )0.5(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw 23.899 0 Td (10.1038/)Tj -23.899 -1.25 Td (ajg.2014.435)Tj 0 0 0 1 k /GS1 gs -0.022 Tw T* (4.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(S)-24(chr)-23.9(eibman)]TJ /Span<>> BDC ( )Tj EMC [(IR, Bak)10(er)]TJ /Span<>> BDC ( )Tj EMC (M, Amos)Tj /Span<>> BDC ( )Tj EMC [(C, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. T)47(he hamar)-22(t)17(oma)15(t)17(ous pol)35.1(ypo)]TJ 0 Tw (-)Tj 0.096 Tw -1.296 -1.25 Td [(sis )0.5(syndr)-31.9(omes: )0.5(a )0.5(cl)-30.9(inical )0.5(and )0.6(molecul)-16(ar )0.5(r)-23.9(ev)-16(iew. )]TJ /T1_4 1 Tf 19.73 0 Td [(Am )0.5(J )0.6(Gastroenterol.)]TJ /T1_1 1 Tf 0 Tw ( )Tj 0.023 Tw -19.73 -1.25 Td [(2005 F)10(eb;100\(2\):476\22690. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1111/j.1572-0241.2005.40237.x)Tj 0 0 0 1 k /GS1 gs 0.02 Tw T* (5.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(V)25(asen)]TJ /Span<>> BDC ( )Tj EMC [(HF, T)45(oml)-30.9(inson)]TJ /Span<>> BDC ( )Tj EMC (I, Castells)Tj /Span<>> BDC ( )Tj EMC [(A. Cl)-31(inical mana)-17(gement of her)-24(edi)]TJ 0 Tw (-)Tj 0.274 Tw -1.296 -1.25 Td [(t)15(ar)-24(y )0.6(col)30(or)-24(ec)-16(t)15(al )0.6(cancer )0.6(syndr)-32(omes. )]TJ /T1_4 1 Tf 14.805 0 Td [(N)18(at )0.6(R)21(ev )0.5(Gastroenterol )0.7(Hepatol.)]TJ /T1_1 1 Tf 0 Tw ( )Tj 0.023 Tw -14.805 -1.25 Td [(2015 F)10(eb;12\(2\):88\22697. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw [(10.1038/nr)-32(gastr)-31.9(o.2014.229)]TJ 0 0 0 1 k /GS1 gs 0.082 Tw T* (6.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (Jelsig)Tj /Span<>> BDC ( )Tj EMC [(AM, Qv)-16(ist)]TJ /Span<>> BDC ( )Tj EMC [(N, Ber)-21.9(telsen)]TJ /Span<>> BDC ( )Tj EMC [(B, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Dist)-32(inc)-16(t gastr)-36.9(ic pheno)17(t)-10(ype )]TJ 0.061 Tw -1.296 -1.25 Td [(in )0.5(p)32(a)15(t)-31.9(ients )0.5(wi)-23.9(t)-13(h )0.5(p)32(a)15(t)-13(ho)-15.9(genic )0.5(v)-15(ar)-36.9(iants )0.5(in )]TJ /T1_4 1 Tf 0 Tw 16.278 0 Td (SMAD4:)Tj /T1_1 1 Tf 0.061 Tw [( )0.6(A )0.5(na)15(t)-32(ionwide )0.6(cr)-32(oss-)]TJ 0.008 Tw -16.278 -1.25 Td [(sec)-16(t)-32(ional stud)17(y. )]TJ /T1_4 1 Tf (Endosc Int Open.)Tj /T1_1 1 Tf ( 2022 Dec 15;10\(12\):E1537\226E1543. )Tj 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1055/a-1954-0522)Tj 0 0 0 1 k /GS1 gs 0.135 Tw -1.847 -1.25 Td (7.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Bl)-16(a)15(t)-30(ter)]TJ /Span<>> BDC ( )Tj EMC [(R, T)60(schupp)]TJ /Span<>> BDC ( )Tj EMC [(B, Ar)-24(e)-12(tz)]TJ /Span<>> BDC ( )Tj EMC [(S, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Disease e)-18(xp)25(r)-23.9(ession in juve)]TJ 0 Tw (-)Tj 0.093 Tw -1.296 -1.25 Td [(nile pol)35(yposis syndr)-31.9(ome: a r)-23.9(e)-12(tr)-32(ospec)-16(t)-31.9(i)-16(ve sur)-32(ve)-11(y on a cohor)-22(t of 221 )]TJ 0.088 Tw T* [(Eur)-32(opean )0.6(p)32(a)15(t)-32(ients )0.5(and )0.6(com)10(p)32(ar)-37(ison )0.6(wi)-24(t)-13(h )0.6(a )0.5(l)-31(i)-24(ter)-32.9(a)15(tur)-24(e-der)-36.9(i)-16(ved )0.5(cohor)-21.9(t )]TJ 0.014 Tw T* [(of 473 SMAD4/BMPR1A p)32(a)15(t)-13(ho)-16(genic v)-15(ar)-37(iant car)-24(r)-37(ier)-9.9(s. )]TJ /T1_4 1 Tf (Genet Med.)Tj /T1_1 1 Tf ( 2020 )Tj 0.023 Tw T* [(Sep;22\(9\):1524\2261532. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1038/s41436-020-0826-1)Tj 0 0 0 1 k /GS1 gs 0.132 Tw T* (8.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(L)35(ee)]TJ /Span<>> BDC ( )Tj EMC [(BG, S)-16(hin)]TJ /Span<>> BDC ( )Tj EMC [(SH, L)35(ee)]TJ /Span<>> BDC ( )Tj EMC [(Y)41(A, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Juvenile pol)35(yp and col)30(onoscopic )]TJ 0.098 Tw -1.296 -1.25 Td [(pol)35(ypec)-16(t)17(omy )0.5(in childho)-16(od. )]TJ /T1_4 1 Tf [(P)15(ediatr )0.5(Gastroenterol Hepatol )0.5(N)21(utr. )]TJ /T1_1 1 Tf 0 Tw 25.638 0 Td (2012 )Tj 0.023 Tw -25.638 -1.25 Td [(Dec;15\(4\):250\2265. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.5223/pghn.2012.15.4.250)Tj 0 0 0 1 k /GS1 gs 0.121 Tw T* (9.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (Gao)Tj /Span<>> BDC ( )Tj EMC [(XH, L)-31.9(i)]TJ /Span<>> BDC ( )Tj EMC (J, Zhao)Tj /Span<>> BDC ( )Tj EMC [(ZY, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Juvenile pol)35(yposis syndr)-31.9(ome might )]TJ 0.16 Tw -1.296 -1.25 Td [(be misdia)-17(gnosed as f)16(amil)-31(ial adenoma)15(t)17(ous pol)35(yposis: a case r)-24(epor)-22(t )]TJ 0.271 Tw T* [(and l)-31(i)-23.9(ter)-33(a)15(tur)-24(e r)-23.9(ev)-16(iew. )]TJ /T1_4 1 Tf (BMC Gastroenterol. )Tj /T1_1 1 Tf (2020 Jun 1;20\(1\):167. )Tj 0 Tw 29.055 40 Td [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1186/s12876-020-01238-7)Tj 0 0 0 1 k /GS1 gs 0.01 Tc 0.371 Tw -1.847 -1.25 Td (10.)Tj /Span<>> BDC ( )Tj EMC 1.836 0 Td (\215\017\022\031\027\024\r)Tj /Span<>> BDC ( )Tj EMC (\212.\236., \214\024\020\017\027\024\r\026)Tj /Span<>> BDC ( )Tj EMC (\202.\203., \025\031\034\n\017\027\024\r)Tj /Span<>> BDC ( )Tj EMC (\202.\204., \017)Tj /Span<>> BDC ( )Tj EMC [(\f\024\026\r\021.)10( )]TJ 0 Tc 0.045 Tw -1.836 -1.25 Td (\236\r\036\027\017\035\034\027\t\005 \023\024\035\017\023\024 \023\024\007\ \n\026\f\022\024\005 \f\036\n\036\005\027\024\020\024 \026\007\036\027\024\ \n\026\021\024\026 \021\024\035\f\021\024\005 )Tj 0 Tw T* (\022\017\001\022\017. )Tj /T1_4 1 Tf 3.197 0 Td (\222\n\023\n\033\032\n\013\024\n\023\n\202\025\002)Tj /T1_1 1 Tf 0.04 Tw [(. 2022;21\(2\):25\22633. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.33878/2073-)Tj -3.197 -1.25 Td (7556-2022-21-2-25-33)Tj 0 0 0 1 k /GS1 gs -0.099 Tw [( / P)-23.9(ikunov)]TJ /Span<>> BDC ( )Tj EMC [(D.Y)35(u., L)35(o)-16(ginov)-14.9(a)]TJ /Span<>> BDC ( )Tj EMC [(A.N., K)25(uzminov)]TJ /Span<>> BDC ( )Tj EMC (A.M., )Tj 0.006 Tc 0.35 Tw T* [(e)-12.4(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Juvenile pol)34.6(yposis in a f)15.6(amil)34.5(y wi)-24.4(t)-13.4(h \253f)15.6(amil)-31.4(ial adenoma)]TJ 0 Tc 0 Tw (-)Tj 0.213 Tw T* [(t)17(ous pol)35(yposis\273)]TJ /Span<>> BDC ( )Tj EMC [(\227 an a)-17(cc)-24(ident)15.1(al f)-28(ind or a na)15(tur)-32.9(al phenomenon? )]TJ /T1_4 1 Tf 0 Tw T* [(K)18(olop)46(roktologia)]TJ /T1_1 1 Tf 0.039 Tw [(. 2022;21\(2\):25\22633. \(in Russ.\). )0.5(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.33878/2073-)Tj T* (7556-2022-21-2-25-33)Tj 0 0 0 1 k /GS1 gs 0.019 Tw T* (11.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Br)-32(osens)]TJ /Span<>> BDC ( )Tj EMC [(L)-34.9(A, L)-32(angeveld)]TJ /Span<>> BDC ( )Tj EMC [(D, v)-15(an Ha)15(t)-30(tem)]TJ /Span<>> BDC ( )Tj EMC [(W)31(A, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Juvenile pol)35(ypo)]TJ 0 Tw (-)Tj 0.121 Tw -1.796 -1.25 Td [(sis syndr)-32(ome. )]TJ /T1_4 1 Tf [(W)29(orld J Gastroenterol. 2)]TJ /T1_1 1 Tf [(011 N)-14(ov 28;17\(44\):4839\22644. )]TJ 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.3748/wjg.v17.i44.4839)Tj 0 0 0 1 k /GS1 gs 0.246 Tw -1.847 -1.25 Td (12.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(v)-15(an Ha)15(t)-30(tem)]TJ /Span<>> BDC ( )Tj EMC [(W)31(A, L)-32(angeveld)]TJ /Span<>> BDC ( )Tj EMC [(D, de L)35(eng)]TJ /Span<>> BDC ( )Tj EMC [(WW, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Hist)17.1(ol)30(o)-16(gic )]TJ 0.009 Tc 0.349 Tw -1.796 -1.25 Td [(v)-14.6(a)0.5(r)-36.5(ia)15.4(t)-31.5(io)0.5(ns)0.5( i)0.5(n ju)0.5(ve)0.5(ni)0.5(le)0.5( po)0.5(l)35.4(y)0.5(p ph)0.5(eno)17.5(t)-9.6(y)0.5(pe)0.5( c)0.5(or)-23.5(r)-23.6(e)0.5(l)-15.6(a)15.5(te)0.5( w)0.5(i)-23.6(t)-12.5(h ge)0.5(ne)-11.5(t)-31.6(i)0.5(c)9( )]TJ 0.351 Tw T* [(defec)-16.4(t under)-30.4(l)34.7(ying juvenile pol)34.7(yposis. )]TJ /T1_4 1 Tf [(Am J Surg P)17.7(athol)]TJ /T1_1 1 Tf [(. 2011)9( )]TJ 0 Tc 0.023 Tw T* [(Ap)25(r;35\(4\):530\2266. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw [(10.1097/P)25(A)35(S.0b013e318211cae1)]TJ 0 0 0 1 k /GS1 gs -0.021 Tw T* (13.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(T)45(omi)-24(t)15(a)]TJ /Span<>> BDC ( )Tj EMC 2.951 0 Td [(N, )0.5(Ishid)42.1(a)]TJ /Span<>> BDC ( )Tj EMC 3.679 0 Td [(H, )0.5(T)40(anak)-17(a)15.1(y)22(a)]TJ /Span<>> BDC ( )Tj EMC 4.883 0 Td [(K, )0.5(e)-11.9(t)]TJ /Span<>> BDC ( )Tj EMC 1.957 0 Td [(al. )0.6(Jap)32(anese )0.5(S)-16(o)-16(c)-23.9(ie)-12(t)-10(y )0.6(for )0.5(Cancer )]TJ 0.253 Tw -15.266 -1.25 Td [(of t)-13(he Col)30.1(on, R)12.9(ec)-16(tum. Jap)32(anese S)-16(o)-16(c)-24(ie)-11.9(t)-10(y for Cancer of t)-13(he Col)30(on )]TJ 0.233 Tw T* [(and R)13(ec)-16(tum \(JSCCR\) guidel)-30.9(ines 2020 for t)-13(he Cl)-31(inical P)35(r)-33(a)-17(c)-16(t)-32(ice of )]TJ 0.005 Tw T* [(Her)-24(edi)-23.9(t)15(ar)-24(y Col)30(or)-24(ec)-16(t)15(al Cancer. )]TJ /T1_4 1 Tf (Int J Clin Oncol. )Tj /T1_1 1 Tf [(2021 A)10(ug;26\(8\):1353\226)]TJ 0.023 Tw T* [(1419. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1007/s10147-021-01881-4)Tj 0 0 0 1 k /GS1 gs -0.031 Tw T* (14.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(S)15(t)17(of)-56(fel)]TJ /Span<>> BDC ( )Tj EMC 2.897 0 Td [(EM, Bol)-15.9(and)]TJ /Span<>> BDC ( )Tj EMC [(CR. Gene)-12(t)-31.9(ics and gene)-12(t)-32(ic )0.5(test)-32(ing in )0.5(her)-24(edi)-24(t)15(ar)-23.9(y )]TJ 0.009 Tc 0.349 Tw -4.693 -1.25 Td [(col)30.1(or)-23.8(ec)-15.9(t)15.1(al Cancer. )]TJ /T1_4 1 Tf -0.009 Tw (Gastroenterology)Tj /T1_1 1 Tf 0.349 Tw [(. 2015;149\(5\):1191\2261203.e2.)9( )]TJ 0 Tc 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td [(10.1053/j.gastr)-31.9(o.2015.07.021)]TJ 0 0 0 1 k /GS1 gs 0.244 Tw -1.847 -1.25 Td (15.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Br)-33(and\343o)]TJ /Span<>> BDC ( )Tj EMC [(C, L)-32(a)-17(ge)]TJ /Span<>> BDC ( )Tj EMC [(J. Mana)-17(gement of P)40(a)15(t)-31.9(ients wi)-24(t)-12.9(h Her)-23.9(edi)-24(t)15(ar)-24(y )]TJ 0.28 Tw -1.796 -1.25 Td [(Col)30(or)-23.9(ec)-16(t)15(al )0.5(Cancer )0.5(Syndr)-32(omes. )]TJ /T1_4 1 Tf 12.866 0 Td [(GE )0.5(P)15(or)-40(t )0.5(J )0.5(Gastroenterol)]TJ /T1_1 1 Tf [(. )0.5(2015 )0.5(A)10(ug )]TJ 0.023 Tw -12.866 -1.25 Td [(14;22\(5\):204\226212. d)-15.9(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1016/j.jpge.2015.06.003)Tj 0 0 0 1 k /GS1 gs -0.019 Tw T* (16.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Ma)-17(car)-32(on)]TJ /Span<>> BDC ( )Tj EMC 3.626 0 Td [(C, )0.5(L)35(ea)-17(ch)]TJ /Span<>> BDC ( )Tj EMC 3.391 0 Td [(BH, )0.6(Bur)-24(k)10(e)]TJ /Span<>> BDC ( )Tj EMC 4.076 0 Td [(C)20(A. )0.5(Her)-23.9(edi)-24(t)15(ar)-24(y )0.6(col)30(or)-24(ec)-15.9(t)15(al )0.5(cancer )0.6(syn)]TJ 0 Tw (-)Tj 0.042 Tw -12.889 -1.25 Td [(dr)-32(omes and gene)-11.9(t)-32(ic test)-32(ing. )]TJ /T1_4 1 Tf (J Surg Oncol.)Tj /T1_1 1 Tf ( 2015 Jan;111\(1\):103\22611. )Tj 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1002/jso.23706)Tj 0 0 0 1 k /GS1 gs 0.192 Tw -1.847 -1.25 Td (17.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Diamond)Tj /Span<>> BDC ( )Tj EMC [(M. A)15(denoma of t)-13(he r)-24(ec)-16(tum in childr)-23.9(en: R)13(epor)-22(t of a )]TJ 0.239 Tw -1.796 -1.25 Td [(case in a t)-13(hir)-21.9(t)-10(y mont)-13(h old gir)-30(l. )]TJ /T1_4 1 Tf (Am J Dis Child.)Tj /T1_1 1 Tf ( 1939;57:360\2267. )Tj 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td [(10.1001/ar)-32(chpedi.1939.01990020118012)]TJ /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\214)10(\211\036\033 \035\030\032\t\033)30(\b)42(\032)-21(\240\033\233)]TJ 57.136 0 Td (REVIEW)Tj /T1_5 1 Tf 25 0 0 25 505.5896 56.0378 Tm (149)Tj ET endstream endobj 871 0 obj <>/Border[0 0 0]/H/N/Rect[128.5 394.841 217.539 385.545]/Subtype/Link/Type/Annot>> endobj 872 0 obj <>/Border[0 0 0]/H/N/Rect[57.2978 354.841 143.945 345.545]/Subtype/Link/Type/Annot>> endobj 873 0 obj <>/Border[0 0 0]/H/N/Rect[233.71 314.841 263.622 305.385]/Subtype/Link/Type/Annot>> endobj 874 0 obj <>/Border[0 0 0]/H/N/Rect[42.5197 304.841 85.1914 295.545]/Subtype/Link/Type/Annot>> endobj 875 0 obj <>/Border[0 0 0]/H/N/Rect[142.054 274.841 258.037 265.545]/Subtype/Link/Type/Annot>> endobj 876 0 obj <>/Border[0 0 0]/H/N/Rect[134.054 244.841 224.037 235.545]/Subtype/Link/Type/Annot>> endobj 877 0 obj <>/Border[0 0 0]/H/N/Rect[57.2978 204.841 128.545 195.545]/Subtype/Link/Type/Annot>> endobj 878 0 obj <>/Border[0 0 0]/H/N/Rect[132.396 154.841 225.867 145.545]/Subtype/Link/Type/Annot>> endobj 879 0 obj <>/Border[0 0 0]/H/N/Rect[116.62 124.841 212.323 115.545]/Subtype/Link/Type/Annot>> endobj 880 0 obj <>/Border[0 0 0]/H/N/Rect[289.739 414.841 387.21 405.545]/Subtype/Link/Type/Annot>> endobj 881 0 obj <>/Border[0 0 0]/H/N/Rect[443.335 384.841 496.063 375.385]/Subtype/Link/Type/Annot>> endobj 882 0 obj <>/Border[0 0 0]/H/N/Rect[274.961 374.841 349.04 365.545]/Subtype/Link/Type/Annot>> endobj 883 0 obj <>/Border[0 0 0]/H/N/Rect[443.335 344.841 496.063 335.385]/Subtype/Link/Type/Annot>> endobj 884 0 obj <>/Border[0 0 0]/H/N/Rect[274.961 334.841 349.04 325.545]/Subtype/Link/Type/Annot>> endobj 885 0 obj <>/Border[0 0 0]/H/N/Rect[289.739 304.841 375.81 295.545]/Subtype/Link/Type/Annot>> endobj 886 0 obj <>/Border[0 0 0]/H/N/Rect[348.148 264.841 454.844 255.545]/Subtype/Link/Type/Annot>> endobj 887 0 obj <>/Border[0 0 0]/H/N/Rect[310.157 214.841 407.628 205.545]/Subtype/Link/Type/Annot>> endobj 888 0 obj <>/Border[0 0 0]/H/N/Rect[289.739 184.841 387.762 175.545]/Subtype/Link/Type/Annot>> endobj 889 0 obj <>/Border[0 0 0]/H/N/Rect[353.381 154.841 444.98 145.545]/Subtype/Link/Type/Annot>> endobj 890 0 obj <>/Border[0 0 0]/H/N/Rect[289.739 124.841 351.362 115.545]/Subtype/Link/Type/Annot>> endobj 891 0 obj <>/Border[0 0 0]/H/N/Rect[289.739 94.8412 424.498 85.5452]/Subtype/Link/Type/Annot>> endobj 912 0 obj <> endobj 911 0 obj <> endobj 910 0 obj <> endobj 909 0 obj <> endobj 908 0 obj <> endobj 907 0 obj <> endobj 906 0 obj <> endobj 905 0 obj <> endobj 904 0 obj <> endobj 903 0 obj <> endobj 902 0 obj <> endobj 901 0 obj <> endobj 900 0 obj <> endobj 899 0 obj <> endobj 898 0 obj <> endobj 897 0 obj <> endobj 896 0 obj <> endobj 895 0 obj <> endobj 894 0 obj <> endobj 893 0 obj <> endobj 892 0 obj <> endobj 774 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 0 0 0 1 k /GS1 gs /T1_0 1 Tf -0.018 Tw 10 0 0 10 70.8661 566.5159 Tm (\017\035\017 \007\017\026\030\036\036\005 [71,72]. \203\024, \031\004\017\ \021\t\r\026\016 \026\022\021\017\r\027\024\036 \030\026\r\017\021\017\036\ )Tj 0.19 Tw 0 -1.218 TD (\220\027\007\024\f\022\024\023\017\004\036\f\022\024\005 \b\017\030\031\030\ \020\017\017, \007\026\027\027\t\036 \022\030\017\021\036\030\017\017 \n\ \024\020\031\021 )Tj 0 Tw T* (\002\t\021\034 \023\036\030\036\f\n\024\021\030\036\027\t.)Tj 0.256 Tw T* [(\216\017\030\031\030\020\017\004\036\f\022\017\036 \r\026\030\017\026\027\ \021\t \035\036\004\036\027\017\016 )0.5(\r\022\035\033\004\026\033\021 \f\031\002\021\024)]TJ 0 Tw (-)Tj 0.05 Tw T* [(\021\026\035\034\027\031\033 \022\024\035\220\022\021\024\n\017\033 )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC (\017\035\036\024\030\036\022\021\026\035\034\027\t\n \026\027\026\f\021\024\ \n\024\024\n )Tj 0.389 Tw T* (\017\035\017 \021\024\021\026\035\034\027\031\033 \022\024\035\023\030\024\ \022\021\220\022\021\024\n\017\033 \f)Tj /Span<>> BDC ( )Tj EMC (\235\024\030\n\017\030\024\r\026\027\017)Tj 0 Tw (-)Tj 0.246 Tw T* (\036\n \021\024\027\022\024\022\017\001\036\004\027\024\020\024 \030\036\ \036\030\r\031\026\030\026. \025\026\022 \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\017 )Tj /T1_1 1 Tf 0 Tw (MutYH)Tj /T1_0 1 Tf (-)Tj 0.386 Tw T* (\026\f\f\024\006\017\017\030\024\r\026\027\027\024\n \023\024\035\017\023\ \024\027\024\n \f\017\027\007\030\024\n\036, \b\017\030\031\030\020\017\ )Tj 0 Tw (-)Tj 0.339 Tw T* (\004\036\f\022\017\005 \024\002\255\036\n \024\023\036\030\026\021\017\r\ \027\024\020\024 \r\n\036\001\026\021\036\035\034\f\021\r\026 \n\024\032\ \036\021 )Tj 0.186 Tw T* (\026\r\017\f\036\021\034 \024\021 \030\026\f\023\030\024\f\021\030\026\027\ \036\027\027\024\f\021\017 \023\024\035\017\023\024\r \r)Tj /Span<>> BDC ( )Tj EMC (\023\030\016\n\024\005 )Tj 0 Tw T* (\022\017\001\022\036 [72].)Tj 0.044 Tw T* (\215\030\017 \r\t\016\r\035\036\027\017\017 \023\024\035\017\023\024\r \r\ )Tj /Span<>> BDC ( )Tj EMC (\032\036\035\031\007\022\036 \220\027\007\024\f\022\024\023\017\004\036\f\ \022\024\036 )Tj -0.007 Tw T* (\035\036\004\036\027\017\036 \n\024\032\036\021 \002\t\021\034 \026\021\ \030\031\007\027\036\027\024, \017)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\026\n \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\027\026)Tj 0 Tw (-)Tj -0.012 Tw T* (\035\017\004\017\017 \f\017\n\023\021\024\n\024\r \(\027\026\023\030\017\ \n\036\030, \021\016\032\036\035\024\005 \026\027\036\n\017\017\) \n\024\ \032\036\021 )Tj 0.067 Tw T* (\023\024\021\030\036\002\024\r\026\021\034\f\016 \f\031\002\021\024\021\026\ \035\034\027\026\016 \017\035\017 \021\024\021\026\035\034\027\026\016 \030\ \036\036\022\006\017\016 )Tj 0 Tw T* (\032\036\035\031\007\022\026 [73].)Tj -0.014 Tw T* (\215\024\f\035\036 \023\030\024\r\036\007\036\027\017\016 \b\017\030\031\ \030\020\017\004\036\f\022\024\020\024 \035\036\004\036\027\017\016 \023\ \026\006\017\036\027\021\t )Tj 0.155 Tw T* (\027\031\032\007\026\033\021\f\016 \r)Tj /Span<>> BDC ( )Tj EMC (\030\036\020\031\035\016\030\027\024\n \023\024\f\035\036\024\023\036\030\ \026\006\017\024\027\027\024\n \220\027\007\024)Tj 0 Tw (-)Tj 0.115 Tw T* [(\f\022\024\023\017\004\036\f\022\024\n )0.6(\027\026\002\035\033\007\036\027\017\017, )0.6(\f\030\024\022\017 )0.5(\022\024\021\024\030\024\020\024 )0.5(\027\026)]TJ /Span<>> BDC ( )Tj EMC 19.489 0 Td (\f\036\020\024\007)Tj 0 Tw (-)Tj -19.489 -1.218 Td (\027\016\001\027\017\005 \007\036\027\034 \004\036\021\022\024 \027\036 \ \024\023\030\036\007\036\035\036\027\t.)Tj /T1_2 1 Tf 0 -2.436 TD (\255\220\006\t\b\t\b\n \t)Tj /Span<>> BDC ( )Tj EMC (\b\004\206\f\211\240\r\b\t\r)Tj /T1_0 1 Tf 0.196 Tw 0 -1.218 TD (\200 \027\026\006\017\024\027\026\035\034\027\t\b \022\035\017\027\017\004\ \036\f\022\017\b \030\036\022\024\n\036\027\007\026\006\017\016\b \r)Tj /Span<>> BDC ( )Tj EMC (\027\026)Tj 0 Tw (-)Tj 0.145 Tw T* (\f\021\024\016\013\036\036 \r\030\036\n\016 \027\036\021 \026\035\020\024\ \030\017\021\n\026 \007\017\026\020\027\024\f\021\017\022\017, \035\036\004\ \036\027\017\016 )Tj -0.008 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\023\024\f\035\036\007\031\033\013\036\020\024 \027\026\002\035\033\007\036\ \027\017\016 \023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\f\017\027\007\030\024\n\024\n )Tj 0.195 Tw T* (\033\r\036\027\017\035\034\027\024\020\024 \023\024\035\017\023\024\026\ , \004\021\024 \020\024\r\024\030\017\021 \024)Tj /Span<>> BDC ( )Tj EMC (\027\036\024\002\b\024\007\017\n\024)Tj 0 Tw (-)Tj 0.259 Tw T* (\f\021\017 \007\026\035\034\027\036\005\001\017\b \017\f\f\035\036\007\024\ \r\026\027\017\005 \007\035\016 \036\020\024 \030\026\030\026\002\024\021\ \022\017 )Tj 0 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\r\027\036\007)Tj /Span<>> BDC ( )Tj EMC 2.698 0 Td (\030\036\027\017\016 [74,75].)Tj 0.044 Tw -2.698 -1.218 Td [(\217\031\021\017\027\027\024\036 )0.6(\020\036\027\036\021\017\004\036\f\022\024\036 )0.6(\021\036\f\021\017\030\024\r\026\027\017\036 )0.5(\007\036\021\036\005 )0.6(\f)]TJ /Span<>> BDC ( )Tj EMC 19.121 0 Td (\030\017\f\022\024\n )Tj -0.052 Tw -19.121 -1.218 Td (\030\026\r\017\021\017\016 \221\236\215 \f\035\036\007\031\036\021 \027\ \026\004\017\027\026\021\034 \r)Tj /Span<>> BDC ( )Tj EMC (\r\024\030\026\f\021\036 12\22615)Tj /Span<>> BDC ( )Tj EMC (\035\036\021. )Tj 0.022 Tw T* (\212\036\021\016\n, \031)Tj /Span<>> BDC ( )Tj EMC (\022\024\021\024\030\t\b \030\026\r\017\r\026\036\021\f\016 \030\036\022\ \021\026\035\034\027\024\036 \022\030\024\r\024\021\036\004\036)Tj 0 Tw (-)Tj 0.126 Tw T* (\027\017\036 \030\026\027\034\001\036 \220\021\024\020\024 \r\024\030\026\ \f\021\026, \f\035\036\007\031\036\021 \023\030\024\005\021\017 \022\024\ \035\024\027\024)Tj 0 Tw (-)Tj -0.027 Tw T* (\f\022\024\023\017\033, \026)Tj /Span<>> BDC ( )Tj EMC (\026\021\036\n \023\030\017\f\021\031\023\017\021\034 \022)Tj /Span<>> BDC ( )Tj EMC (\020\036\027\036\021\017\004\036\f\022\024\n\031 \017\f\f\035\036\007\024\ )Tj 0 Tw (-)Tj T* (\r\026\027\017\033 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\r\t\016\r\035\036\027\017\017 \023\024\035\017\023\024\r \021\024\035\f\ \021\024\005 \022\017\001\022\017 [76].)Tj 0.128 Tw T* (\203\026\030\031\001\036\027\017\036 \f\021\031\035\026 \(\007\017\026\030\ \036\016\), \r\t\023\026\007\036\027\017\036 \023\024\035\017\023\024\r,\ \r\t)Tj 0 Tw (-)Tj 0.35 Tw T* [(\007\036\035\036\027\017\036 )0.6(\022\030\024\r\017 )0.5(\023\030\017)]TJ /Span<>> BDC ( )Tj EMC 9.123 0 Td [(\026\022\021\036 )0.5(\007\036\235\036\022\026\006\017\017, )0.5(\022\035\017\027\017\004\036\f\022\017\036 )]TJ 0.444 Tw -9.123 -1.218 Td (\023\030\024\016\r\035\036\027\017\016 \026\027\036\n\017\017, \023\024\035\ \024\032\017\021\036\035\034\027\t\005 \026\027\026\035\017 \022\026\035\ \026 )Tj 0.124 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC (\f\022\030\t\021\031\033 \022\030\024\r\034 \016\r\035\016\033\021\f\016\ \023\024\022\026\026\027\017\036\n \007\035\016 \r\t\023\024\035)Tj 0 Tw (-)Tj -0.022 Tw T* (\027\036\027\017\016 \220\027\007\024\f\022\024\023\017\004\036\f\022\024\ \020\024 \017\f\f\035\036\007\024\r\026\027\017\016 \024\030\020\026\027\ \024\r \240\025\230. )Tj 0.191 Tw T* (\230\026\022\032\036 \027\036\024\002\b\024\007\017\n\024 \r\t\023\024\035\ \027\017\021\034 \220\027\007\024\f\022\024\023\017\004\036\f\022\024\036\ \017\f)Tj 0 Tw (-)Tj 0.405 Tw T* (\f\035\036\007\024\r\026\027\017\036 \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r, \024\021\027\024\f\016\013\017\b\f\016\ \022)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\026\n )Tj 0.219 Tw 23.244 48.712 Td (\030\017\f\022\026 \(\027\026\023\030\017\n\036\030, \030\024\007\f\021\r\ \036\027\027\017\022\017 \023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\023\024\035\017)Tj 0 Tw (-)Tj T* (\023\024\027\t\n\017 \f\017\027\007\030\024\n\026\n\017\) [77].)Tj 0.089 Tw T* [(\221\030\024\022\017 )0.5(\027\026\004\026\035\026 )0.6(\220\027\007\024\f\022\024\023\017\004\036\f\022\024\020\024 )0.6(\017\f\f\035\036\007\024\r\026\027\017\016 )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC 20.757 0 Td (\023\024)Tj 0 Tw (-)Tj 0.341 Tw -20.757 -1.218 Td (\f\035\036\007\031\033\013\036\020\024 \027\026\002\035\033\007\036\027\017\ \016 \023\030\017\r\036\007\036\027\t \r)Tj /Span<>> BDC ( )Tj EMC (\021\026\002\035\017\006\036 2. )Tj 0.279 Tw T* (\025\024\035\024\027\024\f\022\024\023\017\016 \030\036\022\024\n\036\027\ \007\024\r\026\027\026 \023\026\006\017\036\027\021\026\n \017\035\017 \030\ \024\007)Tj 0 Tw (-)Tj 0.015 Tw T* (\f\021\r\036\027\027\017\022\026\n \023\026\006\017\036\027\021\024\r, \027\ \026\004\017\027\026\016 \f)Tj /Span<>> BDC ( )Tj EMC (12\22615)Tj /Span<>> BDC ( )Tj EMC (\035\036\021\027\036\020\024 \r\024)Tj 0 Tw (-)Tj -0.042 Tw T* (\030\026\f\021\026 \f)Tj /Span<>> BDC ( )Tj EMC (\017\027\021\036\030\r\026\035\024\n \030\026 \r)Tj /Span<>> BDC ( )Tj EMC (1\2263)Tj /Span<>> BDC ( )Tj EMC (\020\024\007\026. \221\030\024\022\017 \r\t\023\024\035\027\036\027\017\016\ )Tj 0.046 Tw T* (\220\024\235\026\020\024\020\026\f\021\030\024\007\031\024\007\036\027\024\ \f\022\024\023\017\017 \026\r\017\f\016\021 \024\021 \r\t\016\r\035\036\ \027\027\024)Tj 0 Tw (-)Tj -0.013 Tw T* (\020\024 \023\026\021\024\020\036\027\027\024\020\024 \r\026\030\017\026\ \027\021\026 \020\036\027\026: \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\023\026\021\024\020\036\027)Tj 0 Tw (-)Tj -0.034 Tw T* (\027\t\n \r\026\030\017\026\027\021\024\n \020\036\027\026 )Tj /T1_1 1 Tf 0 Tw (SMAD4)Tj /T1_0 1 Tf -0.034 Tw ( \022\026\032\007\t\036 1\2263)Tj /Span<>> BDC ( )Tj EMC (\020\024\007\026, \027\026\004\017\027\026\016 )Tj 0.107 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (18 \035\036\021. \211)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\023\026\021\024\020\036\027\027\t\n \r\026\030\017\026\027\021\024\n \020\ \036\027\026 )Tj /T1_1 1 Tf 0 Tw T* [(BMP)66(R1A)]TJ /T1_0 1 Tf 0.162 Tw /Span<>> BDC ( )Tj EMC (\227 \027\026\004\026\035\024 \r)Tj /Span<>> BDC ( )Tj EMC (25 \035\036\021 c \017\027\021\036\030\r\026\035\024\n 1\2263)Tj /Span<>> BDC ( )Tj EMC (\020\024\007\026 )Tj 0 Tw T* ([69].)Tj 0.117 Tw T* (\212\026\027\027\t\036 \f\030\024\022\017 \027\026\002\035\033\007\036\027\ \017\016 \021\026\022\032\036 \024\021\030\026\032\036\027\t \r)Tj /Span<>> BDC ( )Tj EMC (\016\023\024\027)Tj 0 Tw (-)Tj 0.544 Tw T* (\f\022\017\b \022\035\017\027\017\004\036\f\022\017\b \030\036\022\024\n\ \036\027\007\026\006\017\016\b \024\021 2023 \020\024\007\026 )Tj 0.257 Tw T* (\023\024)Tj /Span<>> BDC ( )Tj EMC (\007\017\026\020\027\024\f\021\017\022\036 \017)Tj /Span<>> BDC ( )Tj EMC (\035\036\004\036\027\017\033 \f\017\027\007\030\024\n\026 \033\r\036\027\ \017\035\034\027\024\020\024 )Tj 0 Tw T* (\023\024\035\017\023\024\026 \031)Tj /Span<>> BDC ( )Tj EMC (\007\036\021\036\005 \017)Tj /Span<>> BDC ( )Tj EMC (\r\030\024\f\035\t\b [80].)Tj 0.146 Tw T* (\217\031\021\017\027\027\024\036 \r\t\023\024\035\027\036\027\017\036 \r\ \017\007\036\024\022\026\023\f\031\035\034\027\024\005 \220\027\007\024\f\ \022\024\023\017\017 )Tj 0.072 Tw T* (\007\026\027\027\024\005 \020\030\031\023\023\036 \023\026\006\017\036\027\ \021\024\r \027\036 \030\036\022\024\n\036\027\007\024\r\026\027\024. \230\ \036\n \027\036 )Tj 0.151 Tw T* [(\n\036\027\036\036, )0.5(\024\027\024 )0.5(\n\024\032\036\021 )0.6(\023\030\017\n\036\027\016\021\034\f\016 )0.6(\031)]TJ /Span<>> BDC ( )Tj EMC 14.388 0 Td [(\023\026\006\017\036\027\021\024\r )0.6(\f)]TJ /Span<>> BDC ( )Tj EMC 5.526 0 Td (\023\026\021\024)Tj 0 Tw (-)Tj 0.06 Tw -19.914 -1.218 Td (\020\036\027\027\t\n \r\026\030\017\026\027\021\024\n \020\036\027\026 )Tj /T1_1 1 Tf 0 Tw (SMAD4 )Tj /T1_0 1 Tf 0.06 Tw 13.1 0 Td (\017)Tj /Span<>> BDC ( )Tj EMC (\f \027\026\035\017\004\017\036\n \f\024\f\031\007\017)Tj 0 Tw (-)Tj 0.159 Tw -13.1 -1.218 Td (\f\021\t\b \n\026\035\034\235\024\030\n\026\006\017\005 \(\r \021\024\n \ \004\017\f\035\036, \023\030\036\007\023\024\035\024\032\017\021\036\035\ \034)Tj 0 Tw (-)Tj 0.116 Tw T* (\027\024, \r)Tj /Span<>> BDC ( )Tj EMC (\021\024\027\022\024\005 \022\017\001\022\036\), \f)Tj /Span<>> BDC ( )Tj EMC (\022\035\017\027\017\004\036\f\022\017\n\017 \023\030\024\016\r\035\036\027\ \017\016\n\017 )Tj 0.107 Tw T* (\026\027\036\n\017\017, \027\036\f\n\024\021\030\016 \027\026)Tj /Span<>> BDC ( )Tj EMC (\220\027\007\024\f\022\024\023\017\004\036\f\022\024\036 \031\007\026\035\ \036\027\017\036 \023\024)Tj 0 Tw (-)Tj 0.125 Tw T* (\035\017\023\024\r \017)Tj /Span<>> BDC ( )Tj EMC (\021\013\026\021\036\035\034\027\024\036 \220\027\007\024\f\022\024\023\017\ \004\036\f\022\024\036 \017\f\f\035\036\007\024\r\026\027\017\036 )Tj 0.01 Tw T* (\024\030\020\026\027\024\r \240\025\230 [69]. \224\022\f\023\036\030\021\ \t ESGE \030\036\022\024\n\036\027\007\031\033\021 \024\020\030\026)Tj 0 Tw (-)Tj 0.135 Tw T* (\027\017\004\017\021\034\f\016 \024\f\n\024\021\030\024\n 12-\023\036\030\ \f\021\027\024\005 \022\017\001\022\017 \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r )Tj 0 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\f\017\027\007\030\024\n\024\n \033\r\036\027\017\035\034\027\024\020\024\ \023\024\035\017\023\024\026 [78].)Tj 1.653 Tw T* [(\221\024\020\035\026\f\027\024 \030\036\022\024\n\036\027\007\026\006\017\ \016\n HHT F)10(ound)42(a)15(t)-31.9(ion )]TJ 0.226 Tw T* [(Inter)-15(na)15(t)-31.9(ional, \023\026\006\017\036\027\021\t \f)]TJ /Span<>> BDC ( )Tj EMC (\n\031\021\026\006\017\036\005 )Tj /T1_1 1 Tf 0 Tw (SMAD4)Tj /T1_0 1 Tf 0.226 Tw ( \007\024\035\032\027\t )Tj -0.022 Tw T* (\023\030\024\b\024\007\017\021\034 \f\022\030\017\027\017\027\020 \007\035\ \016 \r\t\016\r\035\036\027\017\016 \f\024\f\031\007\017\f\021\t\b \023\024\ \030\026)Tj 0 Tw (-)Tj -0.027 Tw T* [(\032\036\027\017\005, )0.5(\f\r\016\026\027\027\t\b )0.6(\f)]TJ /Span<>> BDC ( )Tj EMC 8.265 0 Td [(\f\017\027\007\030\024\n\024\n )0.5(\027\026\f\035\036\007\f\021\r\036\027\027\t\b )0.6(\021\036\035\036)]TJ 0 Tw (-)Tj -0.011 Tw -8.265 -1.218 Td (\026\027\020\017\024\220\022\021\026\017\005: \r)Tj /Span<>> BDC ( )Tj EMC (\n\024\n\036\027\021 \023\024\f\021\026\027\024\r\022\017 \007\017\026\020\ \027\024\026 \f\035\036\007\031\036\021 )Tj 0.018 Tw T* (\023\030\024\005\021\017 \f\022\030\017\027\017\027\020 \027\026)Tj /Span<>> BDC ( )Tj EMC (\027\026\035\017\004\017\036 \f\024\f\031\007\017\f\021\t\b \n\026\035\034\ \235\024\030\n\026)Tj 0 Tw (-)Tj 0.024 Tw T* (\006\017\005 \020\024\035\024\r\027\024\020\024 \n\024\020\026, \026)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\032\036 \023\030\024\005\021\017 \027\036 \n\036\027\036\036\ \024\007\027\024\005 )Tj 0.114 Tw T* (\204\217\230 \r)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\017\024\007 \023\024\035\024\r\024\020\024 \f\024\030\036\r\ \026\027\017\016. \203\026\004\017\027\026\016 \f)Tj /Span<>> BDC ( )Tj EMC (\r\024)Tj 0 Tw (-)Tj -0.023 Tw T* (\030\026\f\021\026 35 \035\036\021, \023\026\006\017\036\027\021\026\n \027\ \036\024\002\b\024\007\017\n\026 \036\032\036\020\024\007\027\026\016 \024\ \006\036\027)Tj 0 Tw (-)Tj T* (\022\026 \031\030\024\r\027\016 \020\036\n\024\020\035\024\002\017\027\026\ \017\035\017 \020\036\n\026\021\024\022\030\017\021\026 [79].)Tj 0.257 Tw T* (\215\030\017 \r\t\016\r\035\036\027\017\017 \f\024\f\031\007\017\f\021\024\ \005 \n\026\035\034\235\024\030\n\026\006\017\017 \035\036\020\022\024\020\ \024 )Tj 0.342 Tw T* (\023\030\017)Tj /Span<>> BDC ( )Tj EMC (\023\024\f\021\026\027\024\r\022\036 \007\017\026\020\027\024\026 \030\036\ \022\024\n\036\027\007\031\036\021\f\016 \023\024\f\035\036\007\031)Tj 0 Tw (-)Tj 0.232 Tw T* (\033\013\036\036 \027\026\002\035\033\007\036\027\017\036 \022\026\032\007\ \t\036 3\2265)Tj /Span<>> BDC ( )Tj EMC (\035\036\021 \f)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\r\036\007\036\027\017\036\n )Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0 Tw 9 0 0 9 70.8661 730.483 Tm (\020\004\206\f\t\204\004 2.)Tj 0 0 0 1 k /GS1 gs /T1_1 1 Tf ( \207\032\n\013\025 \r\021\030\n\t\013\n\033\025\006\031\t\013\n\202\n \021\ \026\005\023\007\030\031\021\025\002 \033\026\203\025\031\021\024\n\027 \ \t)Tj /Span<>> BDC ( )Tj EMC (\007\027\031\021\025\023\022\021\020\003 \033\n\023\025\033\n\016\n\003 \ [65])Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0 -1.2 TD [(T)48(able 2)16(.)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf [( T)54.1(er)-14(ms of endoscopic obser)-41.8(v)16(ation of patients with juv)13.2(enile polyposis)]TJ ET 0 0 0 1 K 0.5 w /GS2 gs q 1 0 0 1 70.8661 715.181 cm 0 0 m 96.628 0 l S Q q 1 0 0 1 71.1161 703.9618 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 167.4941 715.181 cm 0 0 m 357.415 0 l S Q q 1 0 0 1 167.4941 703.9618 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 524.6594 703.9618 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 70.8661 703.7118 cm 0 0 m 96.628 0 l S Q q 1 0 0 1 71.1161 692.5005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 167.4941 703.7118 cm 0 0 m 357.415 0 l S Q q 1 0 0 1 167.4941 692.5005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 692.5005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 692.2505 cm 0 0 m 96.628 0 l S Q q 1 0 0 1 71.1161 671.4393 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 167.4941 692.2505 cm 0 0 m 357.415 0 l S Q q 1 0 0 1 167.4941 671.4393 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 524.6594 671.4393 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 70.8661 671.1893 cm 0 0 m 96.628 0 l S Q q 1 0 0 1 167.4941 671.1893 cm 0 0 m 357.415 0 l S Q BT /GS1 gs /T1_2 1 Tf 8 0 0 8 92.7976 706.5464 Tm (\026\002\213\006\004\217\003 \b\004\201\004\f\004)Tj 28.556 0 Td (\034\217\217\f\r\240\002\004\b\t\r)Tj /T1_0 1 Tf -30.912 -1.433 Td (\221 12\22615)Tj /Span<>> BDC ( )Tj EMC (\035\036\021)Tj 27.427 0 Td (\025\024\035\024\027\024\f\022\024\023\017\016 \022\026\032\007\t\036 1\226\ 3)Tj /Span<>> BDC ( )Tj EMC (\020\024\007\026)Tj -27.427 -1.433 Td (\221 18 \035\036\021)Tj 19.012 0 Td (\224\206\212\221 \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\023\026\021\024\020\036\027\027\t\n \r\026\030\017\026\027\021\024\n \020\ \036\027\026 )Tj /T1_1 1 Tf (SMAD4)Tj /T1_0 1 Tf ( \022\026\032\007\t\036 1\2263)Tj /Span<>> BDC ( )Tj EMC (\020\024\007\026,)Tj /T1_1 1 Tf 4.646 -1.2 Td (BMPR1A)Tj /T1_0 1 Tf /Span<>> BDC ( )Tj EMC (\227 \027\026\004\026\035\024 \r)Tj /Span<>> BDC ( )Tj EMC (25 \035\036\021 c \017\027\021\036\030\r\026\035\024\n 1\2263)Tj /Span<>> BDC ( )Tj EMC (\020\024\007\026)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 9 0 0 9 70.8661 654.47 Tm (\020\004\206\f\t\204\004 3.)Tj 0 0 0 1 k /GS1 gs /T1_1 1 Tf ( \207\032\n\013\025 \021\026\005\023\007\030\031\021\025\002 \016\026)Tj /Span<>> BDC ( )Tj EMC (\033\026\203\025\031\021\024\026\003\025 \t)Tj /Span<>> BDC ( )Tj EMC [(\t\025\021\030\032\n\003\n\003 \021\026\t\023\031\030\t\024)0.5(\027\031\021\021\020\004 \024\031\023\031\026\021\202\025\n\r\013\024\026\ \016\025\017 [71])]TJ 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf T* [(T)48(able 3.)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf [( Duration of obser)-41.8(v)16(ation of patients with hereditar)-42.7(y telangiectasia syndrome)]TJ ET /GS2 gs q 1 0 0 1 70.8661 639.168 cm 0 0 m 122.14 0 l S Q q 1 0 0 1 71.1161 627.9488 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 193.0059 639.168 cm 0 0 m 331.904 0 l S Q q 1 0 0 1 193.0059 627.9488 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 524.6594 627.9488 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 70.8661 627.6988 cm 0 0 m 122.14 0 l S Q q 1 0 0 1 71.1161 606.8875 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 193.0059 627.6988 cm 0 0 m 331.904 0 l S Q q 1 0 0 1 193.0059 606.8875 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 524.6594 606.8875 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 70.8661 606.6375 cm 0 0 m 122.14 0 l S Q q 1 0 0 1 71.1161 595.4263 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 193.0059 606.6375 cm 0 0 m 331.904 0 l S Q q 1 0 0 1 193.0059 595.4263 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 595.4263 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 595.1763 cm 0 0 m 122.14 0 l S Q q 1 0 0 1 193.0059 595.1763 cm 0 0 m 331.904 0 l S Q BT /GS1 gs /T1_2 1 Tf 8 0 0 8 105.5535 630.5334 Tm (\026\002\213\006\004\217\003 \b\004\201\004\f\004)Tj 28.556 0 Td (\034\217\217\f\r\240\002\004\b\t\r)Tj /T1_0 1 Tf -32.507 -1.433 Td (\212\036\021\f\022\017\005 \r\024\030\026\f\021 \(\027\026 \n\024\n\036\ \027\021 )Tj 0 -1.2 TD (\023\024\f\021\026\027\024\r\022\017 \007\017\026\020\027\024\026\))Tj 16.545 1.2 Td (\212\036\021\016\n \027\036\024\002\b\024\007\017\n\024 \023\030\024\005\ \021\017 \f\022\030\017\027\017\027\020 \027\026)Tj /Span<>> BDC ( )Tj EMC (\027\026\035\017\004\017\036 \f\024\f\031\007\017\f\021\024\005 \n\026\035\ \034\235\024\030\n\026\006\017\017 \020\024\035\024\r\027\024\020\024 \n\ \024\020\026 )Tj 4.529 -1.2 Td (\017)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\005\021\017 \027\036 \n\036\027\036\036 1 \023\024\f\035\036\ \007\031\033\013\036\005 \204\217\230 \r)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\017\024\007 \023\024\035\024\r\024\020\024 \f\024\030\036\r\ \026\027\017\016)Tj -21.074 -1.433 Td (\200\f\036\n \023\026\006\017\036\027\021\026\n \f\021\026\030\001\036 3\ 5 \035\036\021)Tj 23.993 0 Td (\213\032\036\020\024\007\027\026\016 \024\006\036\027\022\026 \031\030\024\ \r\027\016 \020\036\n\024\020\035\024\002\017\027\026 \017\035\017 \020\036\ \n\026\021\024\022\030\017\021\026)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\214)10(\211\036\033 \035\030\032\t\033)30(\b)42(\032)-21(\240\033\233)]TJ 57.136 0 Td (REVIEW)Tj -57.136 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 23, \023\0221)69(, 202)69(4)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 23, \023\0221)69(, 202)69(4)]TJ /T1_4 1 Tf 25 0 0 25 20.8778 56.0378 Tm (148)Tj ET endstream endobj 773 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\021\220\001\201\002\025\024 \212\r\016\001\220\007\216\001\025\202)10(\025 \221\025\007\220\221\025)21(\222\013 \(\025\f\222\025\002 \007\220\026)11(\016\002\013\026)-20(\215\002\020\))]TJ 45.723 0 Td [(Ju)10(v)12(enile polyposis s)10(yndr)20(ome \(r)31(e)11(vie)11(w\))]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0.028 Tw 10 0 0 10 42.5197 724.8299 Tm (\023\026\006\017\036\027\021 \f)Tj /Span<>> BDC ( )Tj EMC (\221\236\215 \017)Tj /Span<>> BDC ( )Tj EMC (10 \036\r\030\024\023\036\005\f\022\017\b \006\036\027\021\030\024\r, \017\ )Tj /Span<>> BDC ( )Tj EMC (\031\f\021\026\027\024)Tj 0 Tw (-)Tj 0.107 Tw 0 -1.218 TD (\r\017\035\017, \004\021\024 \026\007\036\027\024\n\026\021\024\027\t\036\ \017\035\017 \031\002\004\026\021\t\036 \027\024\r\024\024\002\030\026\ \024)Tj 0 Tw (-)Tj 0.01 Tw T* (\r\026\027\017\016 \r)Tj /Span<>> BDC ( )Tj EMC (\007\024\023\024\035\027\036\027\017\036 \022)Tj /Span<>> BDC ( )Tj EMC (\033\r\036\027\017\035\034\027\t\n \023\024\035\017\023\026\n \r\f\021\030\ \036\004\026)Tj 0 Tw (-)Tj T* (\033\021\f\016 \r)Tj /Span<>> BDC ( )Tj EMC (40\22690% \f\035\031\004\026\036\r [7].)Tj 0.091 Tw T* [(\200 2022 \020\024\007\031 R)11(osner G. \017)]TJ /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. \024\023\017\f\026\035\017 8 \023\026\006\017\036\027\021\ \024\r )Tj 0.003 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC [(\020\036\027\036\021\017\004\036\f\022\017 \023\024\007\021\r\036\030\032\ \007\036\027\027\t\n )0.5(\f\017\027\007\030\024\n\024\n \033\r\036\027\017\035\034)]TJ 0 Tw (-)Tj 0.014 Tw 0 -1.218 TD (\027\024\020\024 \023\024\035\017\023\024\026 \017\f\022\035\033\004\017\ \021\036\035\034\027\024 \f)Tj /Span<>> BDC ( )Tj EMC (\026\007\036\027\024\n\026\021\024\027\t\n\017 \023\024)Tj 0 Tw (-)Tj 0 -1.218 TD (\035\017\023\026\n\017 \r)Tj /Span<>> BDC ( )Tj EMC (\021\024\035\f\021\024\005 \022\017\001\022\036 [54].)Tj 0.014 Tw T* (\200\026\032\027\024 \024\021\n\036\021\017\021\034, \004\021\024 \f)Tj /Span<>> BDC ( )Tj EMC (\023\024\n\024\013\034\033 \017\n\036\033\013\017\b\f\016 \220\027\007\024\ \f\022\024)Tj 0 Tw (-)Tj 0.11 Tw T* [(\023\017\004\036\f\022\017\b \022\035\026\f\f\017\235\017\022\026\006\017\ \005 )0.5(\f\021\030\031\022\021\031\030\031 \033\r\036\027\017\035\034\027\t\b )0.5(\023\024)]TJ 0 Tw (-)Tj T* (\035\017\023\024\r \024\023\017\f\026\021\034 \027\036\r\024\n\024\032\027\ \024 [55\22658].)Tj -0.026 Tw T* [(\200 \f\021\026\021\034\036 W)12(a)15(t)15(anabe )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 8.346 0 Td [(\f\024\026\r\021. )0.5(\031\022\026\026\027\024, \004\021\024 )0.5(\r\024\n\024\032\027\024 )0.5(\r\t)]TJ 0 Tw (-)Tj 0.234 Tw -8.346 -1.218 Td (\016\r\035\036\027\017\036 \023\024\035\017\023\024\r \032\036\035\031\007\ \022\026 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\024\021\f\031\021\f\021\r\017\017 \023\024\035\017\023\024\r )Tj 0.044 Tw 0 -1.218 TD (\r)Tj /Span<>> BDC ( )Tj EMC (\021\024\035\f\021\024\005 \022\017\001\022\036 [59]. \025\026\022 \024\021\ \n\036\004\026\035\024\f\034 \030\026\027\036\036, \023\024\035\017\023\t\ )Tj 0.072 Tw 0 -1.218 TD (\r\036\030\b\027\017\b \024\021\007\036\035\024\r \032\036\035\031\007\024\ \004\027\024-\022\017\001\036\004\027\024\020\024 \021\030\026\022\021\026\ \017)Tj /Span<>> BDC ( )Tj EMC (\030\026\022 )Tj 0.042 Tw T* (\032\036\035\031\007\022\026 \004\026\013\036 \f\r\016\026\027\t \f)Tj /Span<>> BDC ( )Tj EMC (\023\026\021\024\020\036\027\027\t\n \r\026\030\017\026\027\021\024\n \020\ \036\027\026 )Tj /T1_2 1 Tf 0 Tw T* (SMAD4 )Tj /T1_1 1 Tf 3.214 0 Td ([31\22633])Tj /T1_2 1 Tf (. )Tj /T1_1 1 Tf 0.29 Tw 4.115 0 Td (\200)Tj /Span<>> BDC ( )Tj EMC (\027\036\f\022\024\035\034\022\017\b \017\f\f\035\036\007\024\r\026\027\017\ \016\b \017\031)Tj /Span<>> BDC (-)Tj EMC 0.238 Tw -7.329 -1.218 Td (\004\026\035\024\f\034 \023\024\030\026\032\036\027\017\036 \r\036\030\b\ \027\017\b \024\021\007\036\035\024\r \032\036\035\031\007\024\004\027\024\ -\022\017)Tj 0 Tw (-)Tj 0.133 Tw T* (\001\036\004\027\024\020\024 \021\030\026\022\021\026 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\033\r\036\027\017\035\034\027\024\n \023\024\035\017\023\024\036: \023\ \024\035\017\023\t, )Tj 0.8 Tw T* (\023\030\036\017\n\031\013\036\f\021\r\036\027\027\024, \016\r\035\016\033\ \021\f\016 \020\017\023\036\030\023\035\026\f\021\017\004\036\f\022\017\n\ \017 )Tj 0.099 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\030\026\f\023\024\035\026\020\026\033\021\f\016 \r)Tj /Span<>> BDC ( )Tj EMC (\026\027\021\030\026\035\034\027\024\n \024\021\007\036\035\036 \032\036\ \035\031\007\022\026 [60\226)Tj 0.001 Tw T* (62]. \230\026\022\032\036 \r\024\n\024\032\027\024 \r\t\016\r\035\036\027\ \017\036 \021\026\022\017\b \027\036\f\023\036\006\017\235\017\004\036)Tj 0 Tw (-)Tj -0.009 Tw T* (\f\022\017\b \023\030\017\027\026\022\024\r, \022\026\022 \020\017\023\036\ \030\036\n\017\016, \024\021\036\022, \022\024\027\021\026\022\021\027\026\ \016 \022\030\024)Tj 0 Tw (-)Tj 0.218 Tw T* [(\r\024\021\024\004\017\r\024\f\021\034 )0.6(\f\035\017\017\f\021\024\005 )0.5(\024\002\024\035\024\004\022\017 )0.6([6]. )0.5(L)35(eonar)-24(d )0.5(N.B., )]TJ 0.181 Tw T* [(Br)-32(onner M.P. \017)]TJ /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. \024\023\017\f\026\035\017 \022\035\017\027\017\004\036\ \f\022\017\005 \f\035\031\004\026\005 )Tj 0.21 Tw T* (\017\n\036\027\036\027\017\005, \017\n\017\021\017\030\031\033\013\017\b\ \002\024\035\036\027\034 \204\036\027\036\021\030\017\036, \r\t\016\r)Tj 0 Tw (-)Tj 0.1 Tw T* (\035\036\027\027\t\b \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\022\017 \f)Tj /Span<>> BDC ( )Tj EMC (\020\036\027\036\021\017\004\036\f\022\017 \023\024\007\021\r\036\030\032\ \007\036\027\027\t\n )Tj 0 Tw T* (\f\017\027\007\030\024\n\024\n \033\r\036\027\017\035\034\027\024\020\024\ \023\024\035\017\023\024\026 [63].)Tj -0.005 Tw T* (\200 \021\024\027\022\024\005 \022\017\001\022\036 \023\024\035\017\023\t\ \r\t\016\r\035\016\033\021\f\016 \030\036\007\022\024 \(\r 7% \f\035\031\ )Tj 0 Tw (-)Tj 0.033 Tw T* (\004\026\036\r\) \017, \023\030\036\017\n\031\013\036\f\021\r\036\027\027\ \024, \035\024\022\026\035\017\031\036\021\f\016 \r)Tj /Span<>> BDC ( )Tj EMC (\007\r\036\027\026\007\006\026)Tj 0 Tw (-)Tj 0.101 Tw T* [(\021\017\023\036\030\f\021\027\024\005 \022\017\001\022\036 [3,44,64\226\ 66]. W)12(ain \017)]TJ /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. \024\002\027\026)Tj 0 Tw (-)Tj -0.022 Tw T* (\030\031\032\017\035\017, \004\021\024 \023\024\035\017\023\t \007\r\036\ \027\026\007\006\026\021\017\023\036\030\f\021\027\024\005 \022\017\001\022\ \017 \004\026\013\036 )Tj 0.083 Tw T* [(\r\f\021\030\036\004\026\033\021\f\016 )0.6(\031)]TJ /Span<>> BDC ( )Tj EMC 6.233 0 Td [(\027\024\f\017\021\036\035\036\005 )0.5(\023\026\021\024\020\036\027\027\024\020\024 )0.5(\r\026\030\017\026\027\021\026 )0.5(\020\036\027\026 )]TJ /T1_2 1 Tf 0 Tw -6.233 -1.218 Td (SMAD4 )Tj /T1_1 1 Tf ([65].)Tj /T1_3 1 Tf 0 -2.436 TD (\215\002\006\226\002\f\002\n\t\201\r\217\220\002\r \t\217\217\f\r\240\002\ \004\b\t\r)Tj /T1_1 1 Tf 0.311 Tw 0 -1.218 TD (\206\017\023\036\030\023\035\026\017\016 \n\031\006\017\027\024\027\t\b\ \032\036\035\036 \017)Tj /Span<>> BDC ( )Tj EMC (\f\035\017\017\f\021\t\b \022\017\f\021 )Tj 0.192 Tw T* (\030\026\027\t\b \030\026\n\036\030\024\r)Tj /Span<>> BDC ( )Tj EMC (\227 \b\026\030\026\022\021\036\030\027\t\036 \017\n\036\027\036\027\017\ \016, \022\024\021\024)Tj 0 Tw (-)Tj 0.023 Tw T* (\030\t\036 \r\t\016\r\035\016\033\021\f\016 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\023\026\021\024\n\024\030\235\024\035\024\020\017\004\036\f\022\024\n \017\ \f\f\035\036\007\024)Tj 0 Tw (-)Tj 0.137 Tw T* (\r\026\027\017\017 \033\r\036\027\017\035\034\027\t\b \023\024\035\017\023\ \024\r. \212\026\027\027\t\036 \023\024\035\017\023\t \f\024\f\021\024)Tj 0 Tw (-)Tj 0.288 Tw T* (\016\021 \017)Tj /Span<>> BDC ( )Tj EMC [(\007\017\235\235\036\030\036\027\006\017\030\024\r\026\027\027\t\b )0.5(\032\036\035\036\017\f\021\t\b \023\030\024\021\024\022\024\r, )]TJ 0.125 Tw T* (\026)Tj /Span<>> BDC ( )Tj EMC [(\032\036\035\036\017\f\021\026\016 \023\024\035\024\f\021\034 )0.5(\030\026\f\001\017\030\036\027\026 \r)]TJ /Span<>> BDC ( )Tj EMC [(\030\026\027\024\005 )0.5(\f\021\036\023\036\027\017. )]TJ 0.204 Tw T* (\224\021\024 \030\026\f\001\017\030\036\027\017\036 \024\002\t\004\027\024\ \f\024\023\030\024\r\024\032\007\026\036\021\f\016 \017\027\021\036\030\ \f\021\017)Tj 0 Tw (-)Tj 0.378 Tw T* [(\006\017\026\035\034\027\024\005 \020\017\023\036\030\023\035\026\017\036\ \005 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC [(\017\027\235\017\035\034\021\030\026\006\017\036\005 )0.5(\f\021\030\024\n\t )]TJ 0.087 Tw T* (\002\024\035\034\001\017\n \022\024\035\017\004\036\f\021\r\024\n \r\024\ \f\023\026\035\017\021\036\035\034\027\t\b \022\035\036\021\024\022, \021\ \026\022\017\b )Tj 0.035 Tw T* [(\022\026\022 \035\017\n\235\024\006\017\021\t, \023\035\026\n\026\021\017\ \004\036\f\022\017\036 )0.5(\022\035\036\021\022\017, \027\036\005\021\030\024\235\017\035\t )]TJ 0.189 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\220\024\017\027\024\235\017\035\t [67]. \003\026\004\026\f\021\031\033\ \027\026)Tj /Span<>> BDC ( )Tj EMC (\n\024\030\235\024\035\024\020\017\004\036\f\022\024\n )Tj 0.065 Tw T* (\031\030\024\r\027\036 \021\030\031\007\027\024 \024\021\035\017\004\017\ \021\034 \033\r\036\027\017\035\034\027\t\036 \023\024\035\017\023\t \024\ \021 \r\024\f)Tj 0 Tw (-)Tj T* (\023\026\035\017\021\036\035\034\027\t\b \023\024\035\017\023\024\r [53,\ 68].)Tj /T1_3 1 Tf 0 -2.436 TD (\031\t\226\226\r\006\r\b\204\t\004\f\001\b\013\005 \240\t\004\n\b\002\213\ )Tj /T1_1 1 Tf 0.879 Tw 0 -1.218 TD (\212\035\016 \023\030\024\r\036\007\036\027\017\016 \007\017\235\235\036\ \030\036\027\006\017\026\035\034\027\024\020\024 \007\017\026\020\027\024\ \026 )Tj 0.48 Tw T* [(\r\026\032\027\t: )0.5(\021\013\026\021\036\035\034\027\t\005 )0.6(\f\002\024\030 )0.5(\026\027\026\n\027\036\026, )0.6(\031\004\036\021 )0.5(\022\035\017\027\017)]TJ 0 Tw (-)Tj 0.589 Tw T* (\004\036\f\022\024\005 \017)Tj /Span<>> BDC ( )Tj EMC (\220\027\007\024\f\022\024\023\017\004\036\f\022\024\005 \022\026\030\021\ \017\027\t, \030\036\031\035\034\021\026\021\t )Tj 0.133 Tw 23.244 64.543 Td (\n\024\030\235\024\035\024\020\017\004\036\f\022\024\020\024 \017\f\f\035\ \036\007\024\r\026\027\017\016 \017)Tj /Span<>> BDC ( )Tj EMC (\n\024\035\036\022\031\035\016\030\027\024-\020\036)Tj 0 Tw (-)Tj 0.311 Tw T* (\027\036\021\017\004\036\f\022\024\005 \007\017\026\020\027\024\f\021\017\ \022\017. \215\030\017)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\r\036\007\036\027\017\017 \007\017\235\235\036)Tj 0 Tw (-)Tj 0.15 Tw T* (\030\036\027\006\017\026\035\034\027\024\020\024 \007\017\026\020\027\024\ \026 \221\236\215 \027\036\024\002\b\024\007\017\n\024 \031\004\017\021\ \t\r\026\021\034 )Tj 0.525 Tw T* (\f\035\036\007\031\033\013\017\036 \026\002\024\035\036\r\026\027\017\016\ \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\f\021\024\016\027\017\016: \f\036\n\036\005\027\t\005 )Tj 0.153 Tw T* [(\026\007\036\027\024\n\026\021\024\027\t\005 )0.6(\023\024\035\017\023\024\027\t\005 )0.6(\f\017\027\007\030\024\n )0.5(\(\022\035\026\f\f\017\004\036\f\022\026\016 )]TJ 0.084 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\026\021\021\036\027\031\017\030\024\r\026\027\027\026\016 \235\024\030\n\ \026\), )Tj /T1_2 1 Tf 0 Tw (MutYH)Tj /T1_1 1 Tf (-\026\f\f\024\006\017\017\030\024\r\026\027\027\t\005 )Tj 0.18 Tw 0 -1.218 TD (\023\024\035\017\023\024, \f\017\027\007\030\024\n \215\036\005\021\006\ \026-\213\020\036\030\f\026, \f\017\027\007\030\024\n \025\026\031\007\036\ \027\026, )Tj 0.413 Tw 0 -1.218 TD [(\r\024\f\023\026\035\017\021\036\035\034\027\t\036 )0.5(\023\024\035\017\023\t \017)]TJ /Span<>> BDC ( )Tj EMC [(\023\f\036\r\007\024\023\024\035\017\023\t )0.5(\021\024\035\f\021\024\005 )]TJ 0.103 Tw T* (\022\017\001\022\017 \(\022\026\022 \023\030\017\027\026\022 \030\026\027\ \036\036 \023\036\030\036\027\036\f\036\027\027\024\020\024 \r\t\030\026\ \032\036\027)Tj 0 Tw (-)Tj 0.295 Tw T* (\027\024\020\024 \r\024\f\023\026\035\036\027\017\016\), \f\023\024\030\026\ \007\017\004\036\f\022\017\036 \033\r\036\027\017\035\034\027\t\036 \023\ \024)Tj 0 Tw (-)Tj 0.363 Tw T* (\035\017\023\t, \220\027\007\024\n\036\021\030\017\024 \021\024\035\f\021\ \024\005 \022\017\001\022\017 \(\023\024\035\017\023\024\r\017\007\027\026\ \016 )Tj 0 Tw T* (\235\024\030\n\026\) [80].)Tj /T1_3 1 Tf 0 -2.436 TD (\035\r\201\r\b\t\r \t)Tj /Span<>> BDC ( )Tj EMC (\214\002\b\t\003\002\006\t\b\n \212\004\204\t\r\b\003\002)Tj /T1_1 1 Tf 0.287 Tw 0 -1.218 TD (\224\027\007\024\f\022\024\023\017\004\036\f\022\024\036 \031\007\026\035\ \036\027\017\036 \023\024\035\017\023\024\r \016\r\035\016\036\021\f\016\ \023\030\017)Tj 0 Tw (-)Tj 0.055 Tw T* [(\024\030\017\021\036\021\027\t\n )0.5(\n\036\021\024\007\024\n )0.6(\035\036\004\036\027\017\016 )0.5(\023\026\006\017\036\027\021\024\r )0.6(\f)]TJ /Span<>> BDC ( )Tj EMC 17.505 0 Td (\f\017\027\007\030\024\n\024\n )Tj 0.326 Tw -17.505 -1.218 Td (\033\r\036\027\017\035\034\027\024\020\024 \023\024\035\017\023\024\026\ [27]. \221\024\020\035\026\f\027\024 \030\036\022\024\n\036\027\007\026\ )Tj 0 Tw (-)Tj 0.154 Tw T* [(\006\017\016\n )0.5(\036\r\030\024\023\036\005\f\022\024\020\024 )0.5(\024\002\013\036\f\021\r\026 )0.5(\020\026\f\021\030\024\017\027\021\036\f\021\017\027\026\035\034\027\024\ \005 )]TJ 0.144 Tw T* [(\220\027\007\024\f\022\024\023\017\017 )0.5(\(ESGE\) )0.6(\f\035\036\007\031\036\021 )0.5(\031\007\026\035\016\021\034 )0.6(\023\024\035\017\023\t )0.5(\021\024\035\f\021\024\005 )]TJ 0.042 Tw T* (\022\017\001\022\017 \030\026\n\036\030\024\n \002\024\035\036\036 1 \f\ \n [69]. \200\t\002\024\030 \f\023\024\f\024\002\026 \220\027)Tj 0 Tw (-)Tj 0.241 Tw T* [(\007\024\f\022\024\023\017\004\036\f\022\024\020\024 \031\007\026\035\036\ \027\017\016 )0.5(\026\r\017\f\017\021 \024\021 \220\027\007\024\f\022\024\023\017\004\036\ )]TJ 0 Tw (-)Tj 0.232 Tw T* (\f\022\017\b \b\026\030\026\022\021\036\030\017\f\021\017\022 \027\024\r\ \024\024\002\030\026\024\r\026\027\017\016 \017)Tj /Span<>> BDC ( )Tj EMC (\024\f\027\026\013\036\027\017\016 )Tj 0.009 Tw T* (\022\035\017\027\017\022\017. \203\026)Tj /Span<>> BDC ( )Tj EMC (\f\036\020\024\007\027\016\001\027\017\005 \007\036\027\034 \007\024\f\021\ \031\023\027\t \021\026\022\017\036 \n\036\021\024)Tj 0 Tw (-)Tj -0.032 Tw T* (\007\017\022\017, \022\026\022 \023\024\035\017\023\220\022\021\024\n\017\ \016, \n\031\022\024\220\022\021\024\n\017\016 \(EMR\), \007\017\f\f\036\ \022)Tj 0 Tw (-)Tj T* (\006\017\016 \r)Tj /Span<>> BDC ( )Tj EMC (\023\024\007\f\035\017\017\f\021\024\n \f\035\024\036 \(ESD\).)Tj 0.261 Tw T* (\203\036\f\n\024\021\030\016 \027\026)Tj /Span<>> BDC ( )Tj EMC (\023\030\017\024\030\017\021\036\021 \220\027\007\024\f\022\024\023\017\004\ \036\f\022\024\020\024 \035\036\004\036\027\017\016 )Tj -0.001 Tw T* (\007\026\027\027\024\005 \020\030\031\023\023\t \023\026\006\017\036\027\ \021\024\r, \036\020\024 \023\030\017\n\036\027\036\027\017\036 \r\024\n\ \024\032\027\024 )Tj 0.031 Tw T* (\021\024\035\034\022\024 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\023\030\026\r\017\035\034\027\024\005 \017)Tj /Span<>> BDC ( )Tj EMC (\f\r\024\036\r\030\036\n\036\027\027\024\005 \023\024\f\021\026\027\024\r\ \022\036 )Tj -0.032 Tw T* [(\007\017\026\020\027\024\026, )0.5(\004\021\024 )0.6(\002\t\r\026\036\021 )0.5(\026\021\030\031\007\027\017\021\036\035\034\027\024, )0.5(\024\f\024\002\036\027\027\024 )0.6(\022\024\020\007\026 )]TJ 0.02 Tw T* (\023\030\017)Tj /Span<>> BDC ( )Tj EMC 1.773 0 Td [(\220\027\007\024\f\022\024\023\017\004\036\f\022\024\n )0.6(\017\f\f\035\036\007\024\r\026\027\017\017 )0.6(\r)]TJ /Span<>> BDC ( )Tj EMC 14.317 0 Td [(\021\024\035\f\021\024\005 )0.6(\022\017\001\022\036 )]TJ 0.139 Tw -16.091 -1.218 Td (\024\023\030\036\007\036\035\016\033\021\f\016 \021\024\035\034\022\024 \ \026\007\036\027\024\n\026\021\024\027\t\036 \023\024\035\017\023\t, \026\ )Tj /Span<>> BDC ( )Tj EMC (\023\030\017 )Tj 0.505 Tw T* (\n\024\035\036\022\031\035\016\030\027\024-\020\036\027\036\021\017\004\036\ \f\022\024\n \017\f\f\035\036\007\024\r\026\027\017\017 \027\036 \031\007\ \026)Tj 0 Tw (-)Tj 0.144 Tw T* (\036\021\f\016 \024\023\030\036\007\036\035\017\021\034 \023\026\021\024\ \020\036\027\027\t\036 \r\026\030\017\026\027\021\t \020\036\027\024\r )Tj /T1_2 1 Tf 0 Tw (SMAD4)Tj /T1_1 1 Tf ( )Tj T* (\017)Tj /Span<>> BDC ( )Tj EMC /T1_2 1 Tf 0.881 0 Td [(BMP)66(R1A)]TJ /T1_1 1 Tf 0.13 Tw (. \200)Tj /Span<>> BDC ( )Tj EMC (\035\017\021\036\030\026\021\031\030\t \024\023\017\f\026\027\t \f\035\031\ \004\026\017, \022\024\020\007\026 \r\t)Tj 0 Tw (-)Tj 0.206 Tw -0.881 -1.218 Td (\016\r\035\036\027\027\t\036 \n\027\024\032\036\f\021\r\036\027\027\t\036\ \023\024\035\017\023\t \r)Tj /Span<>> BDC ( )Tj EMC (\021\024\035\f\021\024\005 \022\017\001\022\036 )Tj 0.173 Tw T* (\021\030\026\022\021\024\r\026\035\017, \022\026\022 \f\036\n\036\005\027\ \t\005 \026\007\036\027\024\n\026\021\024\027\t\005 \023\024\035\017\023\ \024)Tj 0 Tw (-)Tj 0.142 Tw T* (\027\t\005 \f\017\027\007\030\024\n \017)Tj /Span<>> BDC ( )Tj EMC (\r\t\023\024\035\027\016\035\017 \f\024\024\021\r\036\021\f\021\r\031\033\ \013\017\036 \024\023\036\030\026)Tj 0 Tw (-)Tj T* (\021\017\r\027\t\036 \r\n\036\001\026\021\036\035\034\f\021\r\026 [9,10]\ .)Tj 0.104 Tw T* (\200\f\021\026\036\021 \r\024\023\030\024\f, \004\021\024 \027\036\024\002\ \b\024\007\017\n\024 \r\t\023\024\035\027\017\021\034 \r)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\r\031\033 )Tj 0.407 Tw T* (\024\004\036\030\036\007\034: \n\024\035\036\022\031\035\016\030\027\024\ -\020\036\027\036\021\017\004\036\f\022\024\036 \017\f\f\035\036\007\024\ \r\026\027\017\036, )Tj 0.037 Tw T* (\022\024\021\024\030\024\036 \027\036 \r\f\036\020\007\026 \023\024\r\024\ \035\016\036\021 \024\023\030\036\007\036\035\017\021\034\f\016 \f)Tj /Span<>> BDC ( )Tj EMC (\007\017\026\020\027\024)Tj 0 Tw (-)Tj 0.184 Tw T* (\024\n, \017\035\017 \027\036\023\024\f\030\036\007\f\021\r\036\027\027\ \024 \023\030\017\f\021\031\023\017\021\034 \022)Tj /Span<>> BDC ( )Tj EMC (\b\017\030\031\030\020\017\004\036)Tj 0 Tw (-)Tj T* (\f\022\024\n\031 \035\036\004\036\027\017\033?)Tj 0.005 Tw T* [(N)-14(o)-14(wick)-15.9(i M.J. \017)]TJ /Span<>> BDC ( )Tj EMC (\f\024\026\r\021., \026)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\032\036 Oncel M. \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. \r\t\007\036)Tj 0 Tw (-)Tj 0.06 Tw T* (\035\017\035\017 \f\035\036\007\031\033\013\017\036 \022\030\017\021\036\ \030\017\017 \007\035\016 \r\t\023\024\035\027\036\027\017\016 \b\017\030\ \031\030\020\017)Tj 0 Tw (-)Tj 0.049 Tw T* (\004\036\f\022\024\020\024 \035\036\004\036\027\017\016: \022\024\035\220\ \022\021\024\n\017\016 \n\024\032\036\021 \002\t\021\034 \r\t\023\024\035\ \027\036\027\026 )Tj 0.116 Tw T* (\023\030\017)Tj /Span<>> BDC ( )Tj EMC 1.869 0 Td [(\002\024\035\034\001\024\n )0.5(\022\024\035\017\004\036\f\021\r\036 )0.6(\023\024\035\017\023\024\r, )0.5(\022\030\031\023\027\t\b )0.6(\023\024\035\017\023\026\b )]TJ 0.4 Tw -1.869 -1.218 Td (\017\035\017 \023\024\035\017\023\026\b \f)Tj /Span<>> BDC ( )Tj EMC (\023\024\007\024\030\036\027\017\036\n \027\026)Tj /Span<>> BDC ( )Tj EMC (\035\024\022\026\004\036\f\021\r\036\027\027\031\033 )Tj 0.219 Tw T* (\021\030\026\027\f\235\024\030\n\026\006\017\033 [70]. \215\030\024\235\017\ \035\026\022\021\017\004\036\f\022\026\016 \030\026\007\017\022\026\035\034\ )Tj 0 Tw (-)Tj 0.162 Tw T* (\027\026\016 \024\023\036\030\026\006\017\016 \023\024\022\026\026\027\026\ \023\026\006\017\036\027\021\026\n \f)Tj /Span<>> BDC ( )Tj EMC (\023\024\035\017\023\026\n\017 \021\024\035)Tj 0 Tw (-)Tj -0.003 Tw T* (\f\021\024\005 \022\017\001\022\017, \027\036 \023\024\007\007\026\033\013\ \017\n\017\f\016 \220\027\007\024\f\022\024\023\017\004\036\f\022\024\n\031\ \035\036)Tj 0 Tw (-)Tj 0.106 Tw T* (\004\036\027\017\033 \(>)Tj /Span<>> BDC ( )Tj EMC (50\226100 \023\024\035\017\023\024\r\), \033\r\036\027\017\035\034\027\t\ \n\017 \023\024\035\017\023\026\n\017 )Tj -0.033 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC 0.637 0 Td [(\007\017\f\023\035\026\f\021\017\004\036\f\022\017\n\017 )0.6(\017\n\036\027\036\027\017\016\n\017, )0.6(\026)]TJ /Span<>> BDC ( )Tj EMC 14.463 0 Td [(\021\026\022\032\036 )0.5(\023\026\006\017\036\027\021\026\n )]TJ 0.111 Tw -15.1 -1.218 Td (\f)Tj /Span<>> BDC ( )Tj EMC 0.781 0 Td [(\021\016\032\036\035\t\n\017 )0.5(\032\036\035\031\007\024\004\027\024-\022\017\001\036\004\027\t\n\017 )0.7(\022\030\024\r\024\021\036\004\036\027\017\016\n\017 )]TJ 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 0 Tw 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\214)10(\211\036\033 \035\030\032\t\033)30(\b)42(\032)-21(\240\033\233)]TJ 57.136 0 Td (REVIEW)Tj /T1_4 1 Tf 25 0 0 25 505.6396 56.0378 Tm (147)Tj ET endstream endobj 772 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.006 Tc 0.037 Tw 10 0 0 10 70.8661 724.8299 Tm (60)Tj /Span<>> BDC ( )Tj EMC [(\035\036\021 [4,43]. \221\030\036\007\027\017\005 \r\024\030\026\f\021 \ \023\024\f\021\026\027\024\r\022\017 \007\017\026\020\027\024\026)6( )]TJ 0.079 Tw 0 -1.218 TD (\022\024\035\024\030\036\022\021\026\035\034\027\024\020\024 \030\026\022\ \026 \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\221\236\215 \f\024\f\021\026\r\035\016)Tj 0 Tc 0 Tw (-)Tj 0.006 Tc 0.181 Tw T* (\036\021 34 \020\024\007\026. \214\017\006\026 \f)Tj /Span<>> BDC ( )Tj EMC (\007\026\027\027\t\n \f\017\027\007\030\024\n\024\n \021\026\022\032\036\ \023\024\007)Tj 0 Tc 0 Tw (-)Tj 0.006 Tc 0.35 Tw T* (\r\036\030\032\036\027\t \023\024\r\t\001\036\027\027\024\n\031 \030\017\ \f\022\031 \030\026\r\017\021\017\016 \030\026\022\026 \032\036)Tj 0 Tc 0 Tw (-)Tj 0.006 Tc 0.033 Tw T* (\035\031\007\022\026 \017)Tj /Span<>> BDC ( )Tj EMC (\007\r\036\027\026\007\006\026\021\017\023\036\030\f\021\027\024\005 \022\ \017\001\022\017)Tj /Span<>> BDC ( )Tj EMC (\227 \024\021 11 \007\024)Tj /Span<>> BDC ( )Tj EMC [(20%)6( )]TJ -0.006 Tw T* ([3,4,44,45].)Tj /T1_1 1 Tf 0 Tc 0 Tw 0 -2.436 TD (\020\r\002\006\t\t \220\004\b\204\r\006\002\n\r\b\r\213\004)Tj /T1_0 1 Tf 0.501 Tw 0 -1.218 TD (\217\026\027\036\036 \f\004\017\021\026\035\024\f\034, \004\021\024 \023\ \030\017)Tj /Span<>> BDC ( )Tj EMC (\221\236\215 \035\024\022\026\004\036\f\021\r\036\027\027\026\016 )Tj -0.017 Tw T* (\021\030\026\027\f\235\024\030\n\026\006\017\016 \023\024\035\017\023\024\ \r \023\030\024\017\f\b\024\007\017\021 \r)Tj /Span<>> BDC ( )Tj EMC (\030\036\031\035\034\021\026\021\036 \023\024)Tj 0 Tw (-)Tj -0.019 Tw T* (\f\021\024\016\027\027\t\b \n\036\b\026\027\017\004\036\f\022\017\b \023\ \024\r\030\036\032\007\036\027\017\005 \017)Tj /Span<>> BDC ( )Tj EMC (\r\024\f\023\026\035\017\021\036\035\034)Tj 0 Tw (-)Tj 0 -1.218 TD (\027\t\b \017\n\036\027\036\027\017\005 [44,46].)Tj 0.43 Tw 0 -1.218 TD [(\215\024\n\017\n\024 \220\021\024\020\024 \f\031\013\036\f\021\r\031\036\ \021 \021\036\024\030\017\016, )0.5(\r\t\030\026\032\026\033\013\026\016\f\016 )]TJ 0.605 Tw 0 -1.218 TD (\r)Tj /Span<>> BDC ( )Tj EMC (\023\024\f\035\036\007\024\r\026\021\036\035\034\027\024\f\021\017: \020\ \026\n\026\030\021\024\n\026-\026\007\036\027\024\n\026-\026\007\036\027\ \024)Tj 0 Tw (-)Tj 0.151 Tw 0 -1.218 TD (\022\026\030\006\017\027\024\n\026. \200)Tj /Span<>> BDC ( )Tj EMC (\030\036\031\035\034\021\026\021\036 \030\024\f\021\026 \023\024\035\017\ \023\024\r, \r)Tj /Span<>> BDC ( )Tj EMC (\027\017\b \r\024)Tj 0 Tw (-)Tj 0.014 Tw 0 -1.218 TD [(\027\017\022\026\033\021 )0.5(\007\017\f\023\035\026\f\021\017\004\036\f\022\017\036 )0.5(\017\n\036\027\036\027\017\016, )0.5(\004\021\024 \r)]TJ /Span<>> BDC ( )Tj EMC [(\017\021\024\020\036 )0.5(\023\030\017)]TJ 0 Tw (-)Tj 0.194 Tw 0 -1.218 TD (\r\024\007\017\021 \022)Tj /Span<>> BDC ( )Tj EMC (\030\026\r\017\021\017\033 \026\007\036\027\024\022\026\030\006\017\027\ \024\n\t [47]. \200)Tj /Span<>> BDC ( )Tj EMC (1994)Tj /Span<>> BDC ( )Tj EMC (\020. )Tj -0.043 Tw 0 -1.218 TD [(Subr)-33(amony )0.5(\221. \017)]TJ /Span<>> BDC ( )Tj EMC [(\f\024\026\r\021. )0.5(\024\021\n\036\021\017\035\017, \004\021\024 )0.5(\027\024\r\024\024\002\030\026\024\r\026\027\017\016 )]TJ 0.09 Tw 0 -1.218 TD (\030\026\n\036\030\024\n \n\036\027\036\036 1 \f\n \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\023\026\021\024\n\024\030\235\024\035\024\020\017\004\036\f\022\024\n \017\ \f)Tj 0 Tw (-)Tj 0.114 Tw 0 -1.218 TD (\f\035\036\007\024\r\026\027\017\017 \017\n\036\033\021 \f\021\030\031\022\ \021\031\030\031, \b\026\030\026\022\021\036\030\027\031\033 \007\035\016\ \033\r\036)Tj 0 Tw (-)Tj 0.111 Tw T* (\027\017\035\034\027\t\b \023\024\035\017\023\024\r, \024\007\027\026\022\ \024 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\031\r\036\035\017\004\036\027\017\017 \030\026\n\036\030\024\r )Tj 0.099 Tw 0 -1.218 TD (\024\021 1 \007\024)Tj /Span<>> BDC ( )Tj EMC (2,9 \f\n \031\r\036\035\017\004\017\r\026\036\021\f\016 \004\026\f\021\024\ \021\026 \r\f\021\030\036\004\026\036\n\024\f\021\017 )Tj 0.422 Tw 0 -1.218 TD (\007\017\f\023\035\026\f\021\017\004\036\f\022\017\b \017\n\036\027\036\ \027\017\005, \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\030\026\n\036\030\026\b \002\024\035\036\036 )Tj -0.033 Tw 0 -1.218 TD (3)Tj /Span<>> BDC ( )Tj EMC (\f\n \002\024\035\034\001\017\027\f\021\r\024 \033\r\036\027\017\035\034\ \027\t\b \023\024\035\017\023\024\r \023\024\022\030\t\021\t \220\023\017\ )Tj 0 Tw (-)Tj 0.052 Tw T* (\021\036\035\017\036\n \f)Tj /Span<>> BDC ( )Tj EMC (\007\017\f\023\035\026\f\021\017\004\036\f\022\017\n\017 \017\n\036\027\ \036\027\017\016\n\017, \r\017\031\026\035\034\027\024 )Tj 0 Tw T* (\r\t\020\035\016\007\016 \022\026\022 \026\007\036\027\024\n\t [48].)Tj 0.204 Tw T* (\203\024, \031\004\017\021\t\r\026\016, \004\021\024 \026\007\036\027\024\ \n\026\021\024\027\t\036 \027\024\r\024\024\002\030\026\024\r\026\027\017\ \016 )Tj 0.167 Tw T* (\r\f\021\030\036\004\026\033\021\f\016 \002\024\035\036\036 \004\036\n \r\ )Tj /Span<>> BDC ( )Tj EMC (50% \f\035\031\004\026\036\r \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r )Tj 0.239 Tw 0 -1.218 TD (\f)Tj /Span<>> BDC ( )Tj EMC 0.908 0 Td [(\f\017\027\007\030\024\n\024\n )0.5(\033\r\036\027\017\035\034\027\024\020\024 )0.6(\023\024\035\017\023\024\026, )0.6(\027\026\017\002\024\035\036\036 )0.5(\r\036)]TJ 0 Tw (-)Tj 0.101 Tw -0.908 -1.218 Td (\030\024\016\021\027\t\n \016\r\035\016\036\021\f\016 \023\030\036\007\023\ \024\035\024\032\036\027\017\036, \004\021\024 \022\024\035\024\030\036\022\ \021\026\035\034)Tj 0 Tw (-)Tj 0.084 Tw 0 -1.218 TD (\027\t\005 \030\026\022 \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \030\026\r\017\r\026\036\021\f\016 \017\ )Tj /Span<>> BDC ( )Tj EMC (\026\007\036\027\024\n\026\021\024\027\t\b )Tj 0 Tw T* (\f\021\030\031\022\021\031\030 \023\024)Tj /Span<>> BDC ( )Tj EMC (\022\035\026\f\f\017\004\036\f\022\024\n\031 \023\031\021\017 \022\026\027\ \006\036\030\024\020\036\027\036\026 [49].)Tj /T1_1 1 Tf 0 -2.436 TD (\236\b\240\002\217\220\002\212\t\201\r\217\220\004\235 \220\004\006\003\t\ \b\004)Tj /T1_0 1 Tf 0.176 Tw 0 -1.218 TD (\215\024\035\017\023\t \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\f\017\027\007\030\024\n\036 \033\r\036\027\017\035\034\027\024\020\024 \ \023\024\035\017\023\024\026, \023\030\036)Tj 0 Tw (-)Tj 0.03 Tw 0 -1.218 TD (\017\n\031\013\036\f\021\r\036\027\027\024, \035\024\022\026\035\017\031\ \033\021\f\016 \r)Tj /Span<>> BDC ( )Tj EMC (\021\024\035\f\021\024\005 \022\017\001\022\036 \(98%\), )Tj 0.036 Tw 0 -1.218 TD [(\030\036\032\036 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 3.105 0 Td [(\032\036\035\031\007\022\036 )0.6(\(14%\) )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 7.29 0 Td [(\r )0.5(\021\024\027\022\024\005 )0.5(\022\017\001\022\036 )0.6(\(7%\) )0.5([3,44]. )]TJ 0.286 Tw -10.395 -1.218 Td [(\222\b )0.5(\n\026\022\f\017\n\026\035\034\027\024\036 )0.6(\022\024\035\017\004\036\f\021\r\024 )0.5(\n\024\032\036\021 )0.6(\007\024\f\021\017\020\026\021\034 )0.5(\027\036)]TJ 0 Tw (-)Tj 0 -1.218 TD (\f\022\024\035\034\022\017\b \f\024\021\036\027.)Tj 0.194 Tw 0 -1.218 TD (\236\r\036\027\017\035\034\027\t\036 \023\024\035\017\023\t \016\r\035\016\ \033\021\f\016 \020\026\n\026\030\021\024\n\026\n\017)Tj /Span<>> BDC ( )Tj EMC (\227 \024\002)Tj 0 Tw (-)Tj 0.099 Tw 0 -1.218 TD (\030\026\031\033\021\f\016 \017)Tj /Span<>> BDC ( )Tj EMC (\027\024\030\n\026\035\034\027\t\b \021\022\026\027\036\005 \f\021\036\027\ \022\017 \022\017\001\022\017 \r)Tj /Span<>> BDC ( )Tj EMC (\027\036)Tj 0 Tw (-)Tj 0.204 Tw T* [(\024\002\t\004\027\024\n )0.5(\017\b )0.6(\f\024\004\036\021\026\027\017\017 )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC 11.083 0 Td [(\027\026\030\031\001\036\027\017\036\n )0.5(\f\024\024\021\027\024\001\036\027\017\016 )]TJ 0 Tw -11.083 -1.218 Td (\021\022\026\027\036\r\t\b \220\035\036\n\036\027\021\024\r \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\036\024\002\035\026\007\026\027\017\036\n \f\021\030\024\n\t.)Tj 0.192 Tw 0 -1.218 TD (\224\027\007\024\f\022\024\023\017\004\036\f\022\026\016 \022\026\030\021\ \017\027\026 \033\r\036\027\017\035\034\027\t\b \023\024\035\017\023\024\ \r \007\024)Tj 0 Tw (-)Tj 0.126 Tw 0 -1.218 TD (\f\021\026\021\024\004\027\024 \r\026\030\017\026\002\036\035\034\027\026\ : \033\r\036\027\017\035\034\027\t\036 \023\024\035\017\023\t \021\024\035\ \f\021\024\005 )Tj 0.28 Tw 0 -1.218 TD (\022\017\001\022\017 \035\024\022\026\035\017\031\033\021\f\016 \r)Tj /Span<>> BDC ( )Tj EMC (70% \f\035\031\004\026\036\r \r)Tj /Span<>> BDC ( )Tj EMC (\007\017\f\021\026\035\034\027\024\005 )Tj 0.155 Tw 0 -1.218 TD (\004\026\f\021\017 \f\017\020\n\024\r\017\007\027\024\005 \022\017\001\022\ \017 \017)Tj /Span<>> BDC ( )Tj EMC (\r \023\030\016\n\024\005 \022\017\001\022\036, \n\024\020\031\021 )Tj 0.104 Tw 0 -1.218 TD (\002\t\021\034 \027\026)Tj /Span<>> BDC ( )Tj EMC (\001\017\030\024\022\017\b \024\f\027\024\r\026\027\017\016\b \030\026\n\ \036\030\024\n \r)Tj /Span<>> BDC ( )Tj EMC (\027\036\f\022\024\035\034\022\024 )Tj -0.026 Tw 0 -1.218 TD (\n\017\035\035\017\n\036\021\030\024\r, \026)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\032\036 \027\026)Tj /Span<>> BDC ( )Tj EMC (\027\024\032\022\026\b \030\026\n\036\030\024\n \r)Tj /Span<>> BDC ( )Tj EMC (\027\036\f\022\024\035\034)Tj 0 Tw (-)Tj 0.088 Tw 0 -1.218 TD (\022\024 \f\026\027\021\017\n\036\021\030\024\r. \025\030\031\023\027\t\036\ \023\024\035\017\023\t \n\024\020\031\021 \002\t\021\034 \n\027\024\020\ \024)Tj 0 Tw (-)Tj 0.117 Tw 0 -1.218 TD (\007\024\035\034\004\026\021\t\n\017, \021\024\020\007\026 \022\026\022 \ \n\036\035\022\017\036 \023\024\035\017\023\t \024\002\t\004\027\024 \022\ \030\031\020)Tj 0 Tw (-)Tj 0.113 Tw 0 -1.218 TD (\035\t\036 \017)Tj /Span<>> BDC ( )Tj EMC (\020\035\026\007\022\017\036. \203\026)Tj /Span<>> BDC ( )Tj EMC (\023\024\r\036\030\b\027\024\f\021\017 \023\024\035\017\023\024\r \007\024\ \f\021\026\021\024\004\027\024 )Tj 0.09 Tw 0 -1.218 TD (\004\026\f\021\024 \024\023\030\036\007\036\035\016\033\021\f\016 \220\030\ \024\017\017 \017)Tj /Span<>> BDC ( )Tj EMC (\020\030\026\027\031\035\016\006\017\024\027\027\026\016 \021\022\026\027\ \034 )Tj 0 Tw 0 -1.218 TD ([11,50].)Tj 0.139 Tw 23.244 64.543 Td [(\222\027\235\017\035\034\021\030\026\006\017\016 )0.5(\024\022\030\031\032\026\033\013\036\005 \023\024\035\017\023\t \f\035\017\ \017\f\021\024\005 )0.5(\024\002\024)]TJ 0 Tw (-)Tj 0.04 Tw T* [(\035\024\004\022\017 \(\023\030\017\027\026\022 \253chick)10(en sk)-16(in mucosa\273\) \027\026\017\002\024\035\036\036 \004\026)]TJ 0 Tw (-)Tj 0.037 Tw T* (\f\021\024 \024\023\030\036\007\036\035\016\036\021\f\016 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\035\024\022\026\035\017\026\006\017\017 \023\024\035\017\023\024\r \r)Tj /Span<>> BDC ( )Tj EMC (\f\017\020\n\024)Tj 0 Tw (-)Tj T* (\r\017\007\027\024\005 \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\016\n\024\005 \022\017\001\022\036 [51,52].)Tj 0.026 Tw T* (\215\030\017 \026\027\026\035\017\036 \035\017\021\036\030\026\021\031\030\ \027\t\b \017\f\021\024\004\027\017\022\024\r \220\027\007\024\f\022\024\ \023\017\004\036)Tj 0 Tw (-)Tj 0.138 Tw T* (\f\022\024\036 \024\023\017\f\026\027\017\036 \f\021\030\031\022\021\031\ \030\t \033\r\036\027\017\035\034\027\t\b \023\024\035\017\023\024\r \021\ \024\035)Tj 0 Tw (-)Tj 0.17 Tw 0 -1.218 TD (\f\021\024\005 \022\017\001\022\017 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\221\236\215 \r\f\021\030\036\004\026\036\021\f\016 \021\024\035\034\022\ \024 \r)Tj /Span<>> BDC ( )Tj EMC (\030\026\002\024\021\026\b )Tj -0.015 Tw 0 -1.218 TD [(Br)-32(osens )0.6(L.A. )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC 5.917 0 Td [(\f\024\026\r\021, )0.6(\026)]TJ /Span<>> BDC ( )Tj EMC 3.337 0 Td [(\021\026\022\032\036 )0.6(v)-15(an )0.5(Ha)15(t)-29.9(tem )0.5(W.A. )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC 10.306 0 Td (\f\024\026\r\021. )Tj 0 Tw -19.56 -1.218 Td ([11,12].)Tj -0.039 Tw T* [(\200 \023\031\002\035\017\022\026\006\017\017 v)-15(an Ha)15(t)-30(tem W.A. \017)]TJ /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. \r)Tj /Span<>> BDC ( )Tj EMC (\024\002\013\036\005 \f\035\024\032)Tj 0 Tw (-)Tj 0.257 Tw T* (\027\024\f\021\017 \023\024\r\036\030\b\027\024\f\021\034 154 \033\r\036\ \027\017\035\034\027\t\b \023\024\035\017\023\024\r \002\t\035\026 )Tj 0.238 Tw T* (\024\006\036\027\036\027\026 \r\024 \r\030\036\n\016 \220\027\007\024\f\022\ \024\023\017\004\036\f\022\024\020\024 \017\f\f\035\036\007\024\r\026\027\ \017\016 )Tj 0.065 Tw 0 -1.218 TD (\f)Tj /Span<>> BDC ( )Tj EMC (\023\030\017\n\036\027\036\027\017\036\n \022\030\026\f\017\021\036\035\016\ \017)Tj /Span<>> BDC ( )Tj EMC (\031\r\036\035\017\004\036\027\017\016, 20 \017)Tj /Span<>> BDC ( )Tj EMC (\023\024\035\017)Tj 0 Tw (-)Tj 0.004 Tw 0 -1.218 TD [(\023\024\r \021\026\022\032\036 )0.5(\002\t\035\017 \024\006\036\027\036\027\t )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC [(\023\024\n\024\013\034\033 )0.5(\220\027\007\024\006\017\021\024\f\022\024\023\017\017 )]TJ 0.09 Tw 0 -1.218 TD (\(\f \017\f\023\024\035\034\024\r\026\027\017\036\n \220\027\007\024\f\022\ \024\023\026 \f\024 \f\r\036\030\b\r\t\f\024\022\017\n \031\r\036)Tj 0 Tw (-)Tj 0.203 Tw T* (\035\017\004\036\027\017\036\n)Tj /Span<>> BDC ( )Tj EMC (\227 \b380\). \224\027\007\024\f\022\024\023\017\004\036\f\022\017\036 \017\ \024\002\030\026\032\036\027\017\016 )Tj 0.071 Tw T* (\024\006\036\027\017\r\026\035\017 \f)Tj /Span<>> BDC ( )Tj EMC (\021\024\004\022\017 \030\036\027\017\016 \024\002\013\036\020\024 \r\017\ \007\026 \023\024\035\017\023\024\r, \b\026)Tj 0 Tw (-)Tj 0.057 Tw T* (\030\026\022\021\036\030\017\f\021\017\022\017 \023\024\r\036\030\b\027\024\ \f\021\017, \006\r\036\021\026, \030\017\f\031\027\022\026 \016\n\024\022\ \220\023\017)Tj 0 Tw (-)Tj T* (\021\036\035\017\016 \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\f\031\007\017\f\021\024\005 \026\030\b\017\021\036\022\021\024\027\ \017\022\017 [12].)Tj 0.458 Tw T* (\221\024\020\035\026\f\027\024 \023\024\035\031\004\036\027\027\t\n \007\ \026\027\027\t\n, \b\026\030\026\022\021\036\030\027\t\n\017 \220\027)Tj 0 Tw (-)Tj 0.341 Tw T* (\007\024\f\022\024\023\017\004\036\f\022\017\n\017 \023\030\017\027\026\ \022\026\n\017 \033\r\036\027\017\035\034\027\t\b \023\024\035\017\023\024\ \r )Tj 0.176 Tw T* (\016\r\035\016\033\021\f\016: \020\017\023\036\030\036\n\017\016 \023\024\ \r\036\030\b\027\024\f\021\017, \027\026\035\017\004\017\036 \220\030\024\ \017\017, )Tj 0.008 Tw T* (\001\026\023\024\004\022\017 \002\036\035\024\005 \f\035\017\017. \215\030\ \017)Tj /Span<>> BDC ( )Tj EMC (\024\006\036\027\022\036 \f\021\030\031\022\021\031\030\t \023\024\r\036\ \030\b)Tj 0 Tw (-)Tj -0.015 Tw T* (\027\024\f\021\017 \r\t\016\r\035\016\033\021\f\016 \024\021\022\030\t\021\ \t\036 \016\n\022\017 \f)Tj /Span<>> BDC ( )Tj EMC (\r\024\f\023\026\035\017\021\036\035\034\027\t\n\017 )Tj 0.309 Tw T* (\017\n\036\027\036\027\017\016\n\017, \027\017\022\026\016 \023\035\024\ \021\027\024\f\021\034 \016\n\024\004\027\024\020\024 \030\017\f\031\027\ \022\026 )Tj 0.046 Tw T* ([12]. \210\021\022\030\t\021\t\036 \016\n\022\017 \f\024\024\021\r\036\021\ \f\021\r\031\033\021 \022\017\f\021\024\027\024-\030\026\f\001\017)Tj 0 Tw (-)Tj 0.025 Tw T* (\030\036\027\027\t\n \032\036\035\036\017\f\021\t\n \023\030\024\021\024\ \022\026\n, \026\023\024\035\027\036\027\027\t\n \f\035\017\034\033. )Tj 0.33 Tw T* (\203\017\022\026\016 \023\035\024\021\027\024\f\021\034 \016\n\024\022 \ \024\002\031\f\035\024\r\035\036\027\026 \031\r\036\035\017\004\036\027\027\ \t\n )Tj 0 Tw T* (\017\027\021\036\030\f\021\017\006\017\026\035\034\027\t\n \024\002\255\036\ \n\024\n [53].)Tj 0.241 Tw T* (\203\036\f\n\024\021\030\016 \027\026)Tj /Span<>> BDC ( )Tj EMC 5.861 0 Td [(\021\024, \004\021\024 \033\r\036\027\017\035\034\027\t\036 )0.6(\023\024\035\017\023\t \f\004\017\021\026\033\021)]TJ 0 Tw (-)Tj 0.251 Tw -5.861 -1.218 Td (\f\016 \007\024\002\030\024\022\026\004\036\f\021\r\036\027\027\t\n\017,\ \r)Tj /Span<>> BDC ( )Tj EMC (\035\017\021\036\030\026\021\031\030\036 \r\f\021\030\036\004\026\033\021\ \f\016 )Tj 0.035 Tw T* (\036\007\017\027\017\004\027\t\036 \024\023\017\f\026\027\017\016 \033\r\ \036\027\017\035\034\027\t\b \023\024\035\017\023\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\007\017\f\023\035\026)Tj 0 Tw (-)Tj 0.025 Tw T* [(\f\021\017\004\036\f\022\017\n\017 \017\n\036\027\036\027\017\016\n\017\ . O\245R)-23.9(ior)-24(d)42(an \017)]TJ /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. \024\002\027\026\030\031)Tj 0 Tw (-)Tj 0.115 Tw T* (\032\017\035\017, \004\021\024 7\22614% \023\024\035\017\023\024\r \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\221\236\215 \n\024\020\031\021 )Tj 0 Tw T* (\017\n\036\021\034 \007\017\f\023\035\026\f\021\017\004\036\f\022\017\036\ \017\n\036\027\036\027\017\016 [39].)Tj 0.014 Tw T* (\200 \030\026\002\024\021\036 Gao X.H. \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\023\026\021\024\n\024\030\235\024\035\024\020\017\004\036\f\022\017\b )Tj 0.433 Tw T* (\017\f\f\035\036\007\024\r\026\027\017\017 767 \027\024\r\024\024\002\030\ \026\024\r\026\027\017\005 \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r )Tj 0.192 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\221\236\215 \r)Tj /Span<>> BDC ( )Tj EMC [(8,5% )0.5(\023\024\035\017\023\024\r )0.5(\002\t\035\026 )0.5(\r\t\016\r\035\036\027\026 )0.5(\035\036\020\022\026\016 \007\017\f)]TJ 0 Tw (-)Tj 0.098 Tw T* (\023\035\026\017\016 \017)Tj /Span<>> BDC ( )Tj EMC (\r 0,3% \023\024\035\017\023\024\r)Tj /Span<>> BDC ( )Tj EMC (\227 \021\016\032\036\035\026\016 \007\017\f\023\035\026\017\016 \017\035\ \017 )Tj 0 Tw T* (\026\007\036\027\024\022\026\030\006\017\027\024\n\026 [9].)Tj 0.102 Tw T* [(\215\024 \007\026\027\027\t\n \035\017\021\036\030\026\021\031\030\t, )0.5(\033\r\036\027\017\035\034\027\t\005 )0.5(\023\024\035\017\023 \002\036 )0.5(\007\017\f)]TJ 0 Tw (-)Tj 0.216 Tw T* (\023\035\026\f\021\017\004\036\f\022\017\b \017\n\036\027\036\027\017\005\ \004\026\013\036 \017\n\036\036\021 \020\035\026\007\022\031\033 \f\235\ \036)Tj 0 Tw (-)Tj 0.461 Tw T* (\030\017\004\036\f\022\031\033, \026\004\026\f\021\031\033 \220\030\024\ \017\030\024\r\026\027\027\031\033, \023\024\r\036\030\b\027\024\f\021\034\ . )Tj 0.184 Tw T* (\215\030\017)Tj /Span<>> BDC ( )Tj EMC (\027\026\035\017\004\017\017 \007\017\f\023\035\026\f\021\017\004\036\f\022\ \017\b \017\n\036\027\036\027\017\005 \031)Tj /Span<>> BDC ( )Tj EMC (\023\024\035\017\023\026 )Tj 0.191 Tw T* [(\004\026\013\036 )0.5(\r\f\021\030\036\004\026\036\021\f\016 )0.6(\007\024\035\034\004\026\021\026\016 )0.5(\023\024\r\036\030\b\027\024\f\021\034 )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC 18.975 0 Td (\023\030\017\f\031\021)Tj 0 Tw (-)Tj -18.975 -1.218 Td (\f\021\r\031\036\021 \r\024\030\f\017\027\004\026\021\t\005 \022\024\n\023\ \024\027\036\027\021 [12].)Tj 0.333 Tw T* (\211\004\017\021\t\r\026\016 \030\036\007\022\031\033 \r\f\021\030\036\004\ \026\036\n\024\f\021\034 \r)Tj /Span<>> BDC ( )Tj EMC (\035\017\021\036\030\026\021\031\030\036 \f\024)Tj 0 Tw (-)Tj 0.261 Tw T* (\024\002\013\036\027\017\005, \027\036\024\002\b\024\007\017\n\024 \023\030\ \024\r\036\007\036\027\017\036 \007\024\023\024\035\027\017\021\036\035\034\ \027\t\b )Tj 0 Tw T* (\017\f\f\035\036\007\024\r\026\027\017\005 \007\035\016 \023\024\007\021\ \r\036\030\032\007\036\027\017\016 \007\026\027\027\t\b \r\t\r\024\007\024\ \r.)Tj 0.117 Tw T* (\215\024\n\017\n\024 \033\r\036\027\017\035\034\027\t\b, \031)Tj /Span<>> BDC ( )Tj EMC (\220\021\017\b \023\026\006\017\036\027\021\024\r \n\024\020\031\021 \r\f\ \021\030\036)Tj 0 Tw (-)Tj -0.037 Tw T* [(\004\026\021\034\f\016 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC [(\026\007\036\027\024\n\026\021\024\027\t\036 )0.5(\023\024\035\017\023\t, \004\021\024 \026\021\030\031\007\027\016\036\021\ )0.5(\007\017\026\020)]TJ 0 Tw (-)Tj T* (\027\024\f\021\017\022\031 \026\002\024\035\036\r\026\027\017\016 [9].)Tj 0.37 Tw T* [(Bl)-16(a)15(t)-30(ter R. \017)]TJ /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. \023\030\024\r\036\035\017 \030\036\021\030\024\f\023\036\ \022\021\017\r\027\024\036 \022\024)Tj 0 Tw (-)Tj 0.187 Tw T* (\020\024\030\021\027\024\036 \017\f\f\035\036\007\024\r\026\027\017\036,\ \r)Tj /Span<>> BDC ( )Tj EMC (\022\024\021\024\030\024\036 \002\t\035 \r\022\035\033\004\036\027 221 )Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0 Tw 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\214)10(\211\036\033 \035\030\032\t\033)30(\b)42(\032)-21(\240\033\233)]TJ 57.136 0 Td (REVIEW)Tj -57.136 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 23, \023\0221)69(, 202)69(4)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 23, \023\0221)69(, 202)69(4)]TJ /T1_3 1 Tf 25 0 0 25 20.8652 56.0378 Tm (146)Tj ET endstream endobj 762 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 763 0 obj <>/ExtGState<>/Font<>/ProcSet[/PDF/Text]/Properties<>/Shading<>/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 764 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 765 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 766 0 obj <>/Font<>/ProcSet[/PDF/Text/ImageC]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 921 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\021\220\001\201\002\025\024 \212\r\016\001\220\007\216\001\025\202)10(\025 \221\025\007\220\221\025)21(\222\013 \(\025\f\222\025\002 \007\220\026)11(\016\002\013\026)-20(\215\002\020\))]TJ 45.723 0 Td [(Ju)10(v)12(enile polyposis s)10(yndr)20(ome \(r)31(e)11(vie)11(w\))]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0.069 Tw 10 0 0 10 42.5197 603.0499 Tm (1\))Tj /Span<>> BDC [( )-198( )]TJ EMC 1.37 0 Td (\027\026\035\017\004\017\036 5 \017\035\017 \002\024\035\036\036 \033\r\036\ \027\017\035\034\027\t\b \023\024\035\017\023\024\r \r)Tj /Span<>> BDC ( )Tj EMC (\021\024\035)Tj 0 Tw (-)Tj 0 -1.218 TD (\f\021\024\005 \022\017\001\022\036;)Tj 0.491 Tw -1.37 -1.218 Td (2\))Tj /Span<>> BDC [( )224( )]TJ EMC 1.37 0 Td (\027\026\035\017\004\017\036 \n\027\024\032\036\f\021\r\036\027\027\t\b \ \033\r\036\027\017\035\034\027\t\b \023\024\035\017\023\024\r )Tj 0.818 Tw 0 -1.218 TD (\027\026)Tj /Span<>> BDC ( )Tj EMC 2.024 0 Td [(\023\030\024\021\016\032\036\027\017\017 )0.6(\r\f\036\020\024 )0.5(\032\036\035\031\007\024\004\027\024-\022\017\001\036\004\027\024\020\024\ )]TJ 0 Tw -2.024 -1.218 Td (\021\030\026\022\021\026;)Tj -0.034 Tw -1.37 -1.218 Td (3\))Tj /Span<>> BDC [( )-301( )]TJ EMC 1.37 0 Td (\035\033\002\024\036 \022\024\035\017\004\036\f\021\r\024 \033\r\036\027\ \017\035\034\027\t\b \023\024\035\017\023\024\r \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\027\026\035\017)Tj 0 Tw (-)Tj 0 -1.218 TD (\004\017\017 \007\026\027\027\024\020\024 \007\017\026\020\027\024\026 \ \r)Tj /Span<>> BDC ( )Tj EMC (\f\036\n\036\005\027\024\n \026\027\026\n\027\036\036.)Tj /T1_2 1 Tf -1.37 -2.436 Td (\022\t\217\220 \006\004\213\t\003\t\235 \006\004\220\004)Tj /T1_1 1 Tf 0.133 Tw 23.244 9.742 Td (\215\026\006\017\036\027\021\t \f)Tj /Span<>> BDC ( )Tj EMC (\f\017\027\007\030\024\n\024\n \033\r\036\027\017\035\034\027\024\020\024\ \023\024\035\017\023\024\026 \023\024\007)Tj 0 Tw (-)Tj 0.031 Tw T* (\r\036\030\032\036\027\t \023\024\r\t\001\036\027\027\024\n\031 \030\017\ \f\022\031 \030\026\r\017\021\017\016 \022\024\035\024\030\036\022\021\026\ \035\034)Tj 0 Tw (-)Tj -0.055 Tw T* (\027\024\020\024 \030\026\022\026, \030\026\022\026 \021\024\027\022\024\ \005 \022\017\001\022\017 \017)Tj /Span<>> BDC ( )Tj EMC (\032\036\035\031\007\022\026, \027\024, \r)Tj /Span<>> BDC ( )Tj EMC (\024\021\035\017\004\017\036 )Tj 0.158 Tw 0 -1.218 TD (\024\021 \002\024\035\034\027\t\b \f)Tj /Span<>> BDC ( )Tj EMC (\f\017\027\007\030\024\n\024\n \215\036\005\021\006\026-\213\020\036\030\ \f\026 \017)Tj /Span<>> BDC ( )Tj EMC (\026\007\036\027\024\n\026)Tj 0 Tw (-)Tj 0.131 Tw 0 -1.218 TD (\021\024\027\t\n \023\024\035\017\023\024\027\t\n \f\017\027\007\030\024\ \n\024\n, \007\035\016 \007\026\027\027\024\005 \020\030\031\023\023\t )Tj 0.164 Tw 0 -1.218 TD (\023\026\006\017\036\027\021\024\r \027\036\b\026\030\026\022\021\036\030\ \027\t \r\027\036\022\017\001\036\004\027\t\036 \r\017\007\t \035\024\022\ \026)Tj 0 Tw (-)Tj 0 -1.218 TD (\004\036\f\021\r\036\027\027\t\b \027\024\r\024\024\002\030\026\024\r\026\ \027\017\005 [41,42].)Tj 0.006 Tc 0.028 Tw 0 -1.218 TD (\025\031\n\031\035\016\021\017\r\027\t\005 \030\017\f\022 \022\024\035\024\ \030\036\022\021\026\035\034\027\024\020\024 \030\026\022\026 \f\024\f\021\ \026\r\035\016)Tj 0 Tc 0 Tw (-)Tj 0.006 Tc -0.042 Tw 0 -1.218 TD [(\036\021 )0.5(\024\021 )0.5(17 )0.5(\007\024)]TJ /Span<>> BDC ( )Tj EMC 4.556 0 Td [(22% )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 2.65 0 Td [(\r\024\030\026\f\021\036 )0.5(35 )0.5(\035\036\021 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 7.36 0 Td (68%)Tj /Span<>> BDC ( )Tj EMC 1.973 0 Td [(\227 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 1.879 0 Td [(\r\024\030\026\f\021\036)6( )]TJ 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0 Tc 0 Tw 9 0 0 9 42.5197 730.483 Tm (\020\004\206\f\t\204\004 1.)Tj 0 0 0 1 k /GS1 gs /T1_3 1 Tf ( \212\026\016\023\025\006\025\031 \013\023\025\021\025\006\031\t\013\025\ \004 \033\032\n\002\027\023\031\021\025\017 \027)Tj /Span<>> BDC ( )Tj EMC [(\016\026\027\025\t\025\003\n\t\024\025 \n\024 \033\026\024\n\202)0.5(\031\021\021\n\202\n \027\026\032\025\026\021\024\026 \021\026\t\023\031\ \030\205\031\003\n\202\n \202\031\021\026)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0 -1.2 TD [(T)48(able 1)47(.)]TJ 0 0 0 1 k /GS1 gs /T1_3 1 Tf [( Dif)-39.9(ferences in clinical manifestations depending on the pathog)12.5(enic v)16(ar)-36.9(iant of the inher)-37(ited g)12(ene)]TJ ET 0 0 0 1 K 0.5 w /GS2 gs q 1 0 0 1 42.5197 715.181 cm 0 0 m 226.772 0 l S Q q 1 0 0 1 42.7697 703.9618 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 269.2913 715.181 cm 0 0 m 226.772 0 l S Q q 1 0 0 1 269.2913 703.9618 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 495.813 703.9618 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 42.5197 703.7118 cm 0 0 m 226.772 0 l S Q q 1 0 0 1 42.7697 682.9005 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 269.2913 703.7118 cm 0 0 m 226.772 0 l S Q q 1 0 0 1 269.2913 682.9005 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 495.813 682.9005 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 42.5197 682.6505 cm 0 0 m 226.772 0 l S Q q 1 0 0 1 42.7697 652.2393 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 269.2913 682.6505 cm 0 0 m 226.772 0 l S Q q 1 0 0 1 269.2913 652.2393 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 495.813 652.2393 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 42.5197 651.9893 cm 0 0 m 226.772 0 l S Q q 1 0 0 1 42.7697 631.178 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 269.2913 651.9893 cm 0 0 m 226.772 0 l S Q q 1 0 0 1 269.2913 631.178 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 495.813 631.178 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 42.5197 630.928 cm 0 0 m 226.772 0 l S Q q 1 0 0 1 269.2913 630.928 cm 0 0 m 226.772 0 l S Q BT /GS1 gs /T1_2 1 Tf 8 0 0 8 105.2231 706.5464 Tm (\200\004\003\002\n\r\b\b\013\005 \004\006\t\004\b\003)Tj /T1_4 1 Tf ( BMPR1A)Tj /T1_2 1 Tf 28.591 0 Td (\200\004\003\002\n\r\b\b\013\005 \004\006\t\004\b\003)Tj /T1_4 1 Tf ( SMAD4)Tj /T1_1 1 Tf -30.693 -1.433 Td (\217\036\007\022\024\036 \023\024\030\026\032\036\027\017\036 \r\036\030\ \b\027\017\b \024\021\007\036\035\024\r \240\025\230)Tj 23.704 0 Td (\215\024\030\026\032\036\027\017\036 \r\036\030\b\027\017\b \024\021\007\ \036\035\024\r \240\025\230 \r)Tj /Span<>> BDC ( )Tj EMC (70% \f\035\031\004\026\036\r, \r\t\f\024\022\017\005 \030\017\f\022 )Tj 8.277 -1.2 Td (\030\026\r\017\021\017\016 \030\026\022\026 \032\036\035\031\007\022\026\ )Tj -35.835 -1.433 Td (\200 \021\024\035\f\021\024\005 \022\017\001\022\036 \004\026\013\036 \r\ \f\021\030\036\004\026\033\021\f\016 \026\007\036\027\024\n\026\021\024\ \027\t\036 \023\024\035\017\023\t, )Tj 1.017 -1.2 Td (\b\026\030\026\022\021\036\030\036\027 \f\n\036\001\026\027\027\t\005 \023\ \024\035\017\023\024, \r\024\n\024\032\027\024 \r\t\016\r\035\036\027\017\ \036 )Tj -1.242 -1.2 Td (\022\024\035\024\030\036\022\021\026\035\034\027\024\020\024 \030\026\022\ \026 \002\036 \027\026\035\017\004\017\016 \023\024\035\017\023\024\r \r\ )Tj /Span<>> BDC ( )Tj EMC (\021\024\035\f\021\024\005 \022\017\001\022\036)Tj 29.149 2.4 Td (\200 \021\024\035\f\021\024\005 \022\017\001\022\036 \004\026\013\036 \r\ \f\021\030\036\004\026\033\021\f\016 \033\r\036\027\017\035\034\027\t\036\ \023\024\035\017\023\t, )Tj 3.983 -1.2 Td (\r\024\n\024\032\027\024 \r\t\016\r\035\036\027\017\036 \026\007\036\027\ \024\n\026\021\024\027\t\b)Tj -20.879 -2.633 Td (\226)Tj 17.155 0 Td (\200 30% \f\035\031\004\026\036\r \f\024\004\036\021\026\027\017\036 \f)Tj /Span<>> BDC ( )Tj EMC (\f\017\027\007\030\024\n\024\n \027\026\f\035\036\007\f\021\r\036\027\027\ \t\b )Tj 4.111 -1.2 Td (\020\036\n\024\030\030\026\020\017\004\036\f\022\017\b \021\036\035\036\026\ \027\020\017\024\220\022\021\026\017\005)Tj ET q /GS0 gs 453.543294 0 0 119.9849984 42.5196991 368.5581229 cm /Im0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf -0.015 Tw 9 0 0 9 42.5197 357.7172 Tm (\022\t\217\210\b\002\220 1.)Tj 0 0 0 1 k /GS1 gs /T1_3 1 Tf ( \223\027\031\021\025\023\022\021\020\031 \033\n\023\025\033\020 \024\n\023\ \t\024\n\017 \013\025\001\013\025 \(\n\t\003\n\024\032 \027)Tj /Span<>> BDC ( )Tj EMC (\005\031\023\n\003 \t\027\031\024\031\))Tj /Span<>> BDC ( )Tj EMC (\227 \f\n\024\n\202\032\026\f\025\025 \025\016)Tj /Span<>> BDC ( )Tj EMC (\026\032\004\025\027\026 \n\024\030\031\023\026 \r\021\030\n\t\013\n\033\ \025\006\031)Tj 0 Tw (-)Tj T* (\t\013\n\017 \030\025\026\202\021\n\t\024\025\013\025 \025)Tj /Span<>> BDC ( )Tj EMC (\004\025\032\205\032\202\025\025 \225\210\213\214 \253\217\240\215\037 \013\ \n\023\n\033\032\n\013\024\n\023\n\202\025\025 \025\003\031\021\025 \201\ .\217.)Tj /Span<>> BDC ( )Tj EMC 30.097 0 Td (\212\020\204\025\004\273 \240\025\021\016\030\032\026\027\026 \212\n\t\t\ \025\025)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.026 Tw -30.097 -1.2 Td [(F)-16(igure 2)16(.)]TJ 0 0 0 1 k /GS1 gs /T1_3 1 Tf [( Juv)13(enile colon polyps \(white-light e)-15(x)10(amination\))]TJ /Span<>> BDC ( )Tj EMC [(\227 from the archiv)13(e of the Depar)-40(tment of Endoscopic Diagnostics and )]TJ 0 Tw T* [(Surg)12(er)-43(y of the Ryzhikh N)18.2(ational Medical R)21.2(esearch Center of Colop)46.1(roctology)]TJ ET q /GS0 gs 453.543294 0 0 181.4173176 42.51968 133.3959148 cm /Im1 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.011 Tw 9 0 0 9 42.5197 122.5959 Tm [(\022\t\217\210\b\002\220 )0.6(2.)]TJ 0 0 0 1 k /GS1 gs /T1_3 1 Tf [( )0.5(\223\027\031\021\025\023\022\021\020\031 )0.6(\033\n\023\025\033\020 )0.6(\024\n\023\t\024\n\017 )0.6(\013\025\001\013\025 )0.6(\(\201. )0.5(\255\t\003\n\024\032 )0.6(\027)]TJ /Span<>> BDC ( )Tj EMC 26.242 0 Td [(\005\031\023\n\003 )0.6(\t\027\031\024\031, )0.6(B. )0.5(\255\t\003\n\024\032 )0.6(\027)]TJ /Span<>> BDC ( )Tj EMC 10.836 0 Td [(\205\016\013\n\003 )0.6(\t\033\031\013\024\032\031 )0.6(\t\027\031\024\026\))]TJ /Span<>> BDC ( )Tj EMC 9.439 0 Td [(\227 )0.5(\f\n\024\n)]TJ 0 Tw (-)Tj 0.09 Tw -46.517 -1.2 Td (\202\032\026\f\025\025 \025\016)Tj /Span<>> BDC ( )Tj EMC [(\026\032\004\025\027\026 \n\024\030\031\023\026 \r\021\030\n\t\013\n\033\ \025\006\031\t\013\n\017 )0.5(\030\025\026\202\021\n\t\024\025\013\025 )0.5(\025)]TJ /Span<>> BDC ( )Tj EMC (\004\025\032\205\032\202\025\025 \225\210\213\214 \253\217\240\215\037 \013\ \n\023\n\033\032\n\013\024\n\023\n\202\025\025 \025\003\031\021\025 \201\ .\217.)Tj /Span<>> BDC ( )Tj EMC (\212\020\204\025\004\273 )Tj 0 Tw T* (\240\025\021\016\030\032\026\027\026 \212\n\t\t\025\025)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.066 Tw T* [(F)-16(igure )0.5(2)16(.)]TJ 0 0 0 1 k /GS1 gs /T1_3 1 Tf [( Juv)13(enile colon )0.5(polyps )0.5(\(A. White-light )0.5(e)-15(x)10(amination, )0.6(B. N)18(ar)-16(row-band )0.5(imaging e)-14.9(x)9.9(amination\))]TJ /Span<>> BDC ( )Tj EMC [(\227 from )0.5(the archiv)13(e of the )]TJ 0 Tw T* [(Depar)-39.9(tment of Endoscopic Diagnostics and Surg)12.3(er)-43(y of the Ryzhikh N)18.1(ational Medical R)21(esearch Center of Colop)46(roctology)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\214)10(\211\036\033 \035\030\032\t\033)30(\b)42(\032)-21(\240\033\233)]TJ 57.136 0 Td (REVIEW)Tj /T1_5 1 Tf 25 0 0 25 505.5273 56.0378 Tm (145)Tj ET endstream endobj 922 0 obj <>stream Adobed     '$''''$25552;;;;;;;;;;   %%#(((((#,0000,7;;;7;;;;;;;;;;   %%#(((((#,0000,7;;;7;;;;;;;;;;   %%#(((((#,0000,7;;;7;;;;;;;;;;<""  y !1AQa"2qB#Rb $%&'()*3456789:CDEFGHIJSTUVWXYZcdefghijrstuvwxyz}!1AQaq"2Bb#3RSr $%&'()*456789:CDEFGHIJTUVWXYZcdefghijstuvwxyz?Q3)ivK_EV+7 Xu@QUq13kh`)pN`94bIeً+?l|îؒ#=UMgJTkf q_>t7s3N )P%H!@td::TXyW84IT%BJZJc&IHY"i) ! >EEЄ! (JH $Bt*`&̡<1B)Ѣb\!!!7EiB0BsXcVlDBXOa[ax+B5B!BΡOPX%H,J\CFe"P%B v#5INLtj֮Irm§h>U3a/5q[ˇ=\$ݵv3k5 EDTBB骀RR4QI4*bTn)8\nL F@K @BUyCZ5)ZMh FR*q r= N\ %8[Rx6LjM%FJs TaԝMbIND%!Hj֤e"MF n'&2B!K ٙ}^KGUtan$tRۣOSZШ\*"d{ w*BsKэ 8Ԥgbqs2nUJBPR!W .Jc zAݘf !U!ًd:SdM[s#5"Rjkr T{s@i/.ճRX=J^JǓ&R0Ɏ4sXǙ q$oUD9.&)nSӸ7J$iMk`GaTL}jK)&Ę)IP8d4 +`6{AIhid'ݔqHݠ;S=:˪ n<v vtgqN>4QI5ow  NsQ%qrT,kFXs&WڶMFv=vhMkq#NG ɛ5x`A` kD@N V4'8,HU pNi+C vܓn=z$2jJ"' T!9){{v63 ZqMR4")>Lr'6.BE6ؑ͘vԾ1Gvpv=bˌ09:|NmxxMڎ;mij-C W'VM@ 2M TM*X" )bcSi14{*wo# 3vs{mU3v]&(-a"؊4֗*mp%=G٭#' HEwSGrvJŶ?fi0Fp+m8cN[=ٱҫ!`XYB퐘Ƿ2SЄ!*D!@ΡOPX%H,Xلc9J*LʹV_hākusc“[ ݽw{w=l;3=9Ypn{ILxA)BUet.qTnzԐJX (l%)hK,"{h'SYHQ#(_UxFRR3H S'xNu1.Z/T%Cm8{.0܁1S`)>iY=qK?zZGO\VL%\׵ɛ.Ʈs^ֿ&lo \Lҁ*T(ɕo qq=(UҤ(BDS1BDIS&b iNkkyGmt(ÄԍCT/c_L@\"VVHTx-" 򪽅q%R1s]\{Nj$渶@$XưaB 4FeKc󼵬(:VlHr5dtDly*a& eD IGSl8ٱ9Ih %,@lYRp߇@:Jɣ *%0sHH!9GaKtH(J!)ª;1 Zd'QFH*rQÀaa37v\'JnXatfGQ|YmaLPZ_xE&А wlĒOU7Q4J҉0֒lO,n6,gۼP+ԛ%&֝ҠYTkhpcbhz?QLR6f &rSicYldF1B~6\ي3=ƂI[6k3 $#iцI1x XCCgP%QoPippsZƥ1Xci<^0 '\Z.^jYU"%v+4cCCX`@k":'b4׊Ke1'A:(<]~%*fq$ĚU(ɌRpp6-5JңWjYLȫ7ŞYB>jS mN@.kf .At1K./dƈZL4Ehh] W.c6p˰߆1sbG1PTHBʂBD Ρ XNzq0'.L.X%H,}h.ω}+LtgFa fhf$+Y݀`/A |}=>a98d#sRJz%3U;!nFiJ[xLm8$GIe!R)JB5JH Sԑ:NઽWڧkr@v$N #UgyVsUY9UxuНT!1YsT%y֞5$d: "fwLŎJN#^Ni-Te4U]tv#cC&mJXe 4#(MuP!+)I9AB`瞴1vR!BUBV AQJ B$@HW#^ l-* M7OTi%Bua/D:SʣJBᚌ+L4\aVXK -*aiֹikN`Q>c`x|il[KL|;6&bq: J､vǾ2~*eg.BkH,`+.k!Tq2(ڱs8(:Q8AM@ⵀSswR^%& rauR_RڝJXYER؋J&ĚMQ)]S3^ϐAl;$H &yT )LBlF0@(lnl!&!1҆bJPS"l=ZII*>0H^P)ZʓZY.&Ln &DuIx7Lv2.I!&BZMp`Uc* b)h\ֆDInB&8f!£`;"u,h"E$Kk^)2Al^$!&8dJun#iNZƕdEe pԜM& Vk&BIh4%$OBA,;+ej0.IC[4􆚴Ѱ&`u6U D̒ܤennxa\Nm4bHZ .ڀ˨*qs\ǜtm& o"R2he7xH^b7B IAZ#2 \/Ot{k8R}): zq>ߙx0GJF2A Bv֑d5}d g0=~La0N5l7Xֿ&\o? P Ңq! *`Je >t$J4t1j)Lsn.Ok)0HH˿! %q*&4ca3G+-iW6Vc9u\-,<1x!ItY!^Mn7(1!xjB*NᢕRoQZ NTTF' Y(Jޕ#aN,RfiScU )Ɖ 5&'ĦBGBxV5 j'd#(Ɏi-Ie]S1ZB[+U!B*v x"xЈN 1VH&UP# "%JvI7.@U߂=r֩JiuJK]gGL$ZnL*˰zG +w=5HRIH"sH) Sa[iRnU1ZD):hHj!\1jXdP!*EdctB'zRA9I*B!F,blzYB3O6%*P(U*FȲ @R5Nڪ*v:0䤋BFuGae)¶Mt VjS@K1Sppi"j;Jm*5 BSS CA]a[W6L5#aaa i>z`)>iY=rٵ]gɗ&ƭR`J2}8ըPQܧ<q4I)e"4C\ "Tb)iړu#.)BbUJDÚ{n^.9ZBͱQilnOZŐD+[#8z@e6Y+ҩ: V2<0T9 NJnWQ-s2qSrDXQV|DVۋl7 EuXgwvykHaѷe&OLZ'R7)VkדRcjM1$\l\4\'=}.:`Ǒ MuZ8x!_M3c1EeCynN[3{_۱.'ʨaŲIlM/v*, t 0HФu@ڠ9w(F!6¦[{6O]OP:msf20Vx,JZ OTx\ 3PEz҂ `Lz0";gRTw(cEFISI=!]+ 8$JVZ_2qLX*;0ʨxl-m@]H \LEcZHOLG>ZAlYap8WDHhӬWn9}&21S7!qm[؂}E5]0iU^IUQ{\Kdo%!ژpaq>5 `m$;38kIVp,(lnpMDRn3xNpc摟m [6$:Yw<`a8; 5hӤAڵIMipyEK(/|\cQΉ EF)Re&߽$($W1S?eoAhf͆W8m.ԻQnѶQ^蝯ZrPU_NTyBT %: y P{u(*+ujHBtl67סba\3VD%QJl.x{o`oB7ܦ=Bក6!#+fc}SEwvϙsiӮeҾL7{,¯1c& ǔrwnג 1^6fo29!HE#(# B6CM³PPur*qd"ցbXdBaqŎ 8h q@vh-s@Gw%.1ZFb/9-qߐ^ɠ6Hy")UbL`^n#l"q"&7k eacNka-sτHRJ s(yrS s,;QBDdG PR9;$NNn " DֹoU,He JsFļ4ȴ+:;FӅ su9:3Xj ˞s; yW{DHJ5)\ ̝A;8|D$ 1o6{Hfdʲ"mUP-T&3aP^Py-]os*AT2 5V4=6NgENxʭedNRݑSqSk 6:Pk)F9iH:Mk^É #z%N:19iKPXDB%1spHkҤÆ D=I2Ў%K`y1rr$a2bFA9Pص$p1vxRES-֔Q)U᭨8Snfqۧ1 j MԠnVdM9XDiϥFBNV>|D /Uch3Χ,OMۼbS*#:$kE\$co-tO|$uܼa$.( g)# T.LV` ikx$VYNZNs$NjffOLc`6@)pT E \^? DL9̌1j|AFt脁ҫ1I(r+L.BnM N ᐞQ)V:Sd邔&#Ex)_TI;RlHSV䋺Js bJ+ YouPi[? wAR'& 9O:B,lEQ4˜ڸ&.k .j2.QLE$S˪Dڇ7 E+58<9@RT(a`&oJL9%D5F35U eCn!M&@Zֱ:e^-2sH9V1sV` k/ڏo.fqq8s^:-Ęz3rWMy&jx5Г4HmдK\nkmFcBJ# E`%^`FP5%6N12I5Diy:仩@iLQ'T rspdN=EsZ\EDGL)!<8hNkOI)Z6p\"q ֡7<j/*fg^:AլHL'Y=ZqN2*1kI#UQv`y!: !FmyeStM8pו0ZgR=z*&fE5tafQg$NKŸ40cziEn:A3Hytۄ@(#ƤksP)نlm@6:ggd54#Ģy#3E !N ڗ TwT;)9WW tK#!PZV!XMqdF&PD(-AﮤkEӬEH 7y#>9IS1q "q`"jx)xE,,&B@ VS 7M` =u:O|ҬSˠZhUl%UvhpHq~,=ăUǨYsovHI汝.&IF{ƍslLv ,qĂ/pAԟF:)wk $#~B2UDC̒A kEcwTm8w8`k X JڶqҲLg}%px/[ġp2r%GQĴEIX}1nU%e5O W(` LP !qnfOh?na$2d ' R6E.2%qe΢sH/j͚D\~6̒bjd'OaJ>+wgюeфؒ]Bǰl[.0 ];\`-Tù,"StM&B6C[;1$h~ӞӮ{6F L BFζ{-sË&+/Cе]~+\"=ܧ-C+J~RDUv!&;OU FiGn5M2 8`&AѴVcj>wH}0/ysJH̀'REL5n8몵XIKA$pPTRfӢ8 -h%ݲQ̨T.)y<`fT{_'7&GP3:Ha:ƶi`#I#ʵ=ߊZ4qֱ^h2 BV]g$X(NѴqu :6s!1,d+̨\h>RjZ'u<= @m\LW{c7;1*6< 6`vo"^HtH;t93"f#_MHFEؑ8ApJDža}:mҴN =wN) e:2%H,M)SJV+Tl v *-(#!Ҫ8++n>Mfnz ĴEq^8SޘQlJ uR uXTzָ$p%U}S~Omd̑;TeKuU)U5~"5mª<%G]$E9՚;lHqN+A4>F[ىhE+0srTݯjnDŽ^bb/ڬТ$ u@e< "(ɶXl0@ ,ZC{B&4ͷk~1~#%ƧIs^s:*CTmGQOJɞKOIFnhp& %N X$ɩ]ժƩVTڕ3*4i-=͂$8 /$:O'+i;*pm@`립 > S7_p 'TkWrDNNװq%!s$d2C8Þ9X:QZQxt (pp0kiF "L^ↈ9Zqq@9 Vǚ&. u&njF:LNhM,w2"{hCH1[ʆRsOgem8E>4#<;TXE!f^IC'RZIZN vXm'}3c]?DcxCNR_Έk%tn[% h59tLMalȐpOGDi6G@f9L}<5΍H1Vlq6e='J5)0Ѧ6)":',@Tm4OZ`'JxltTU\nADЛr ]oaE`nVDT!BYD(M%RFDRTrf0VvL+fҹg.[sN'L%R]hE**wȒ,Jv&4 S T,@I2$N HhS\bR,A]JޒSA$tO)9zCh$Mq&(u $ E/Z8睒 ;TǤGѪ6&t,DM* |IpT{2DLT>˳ll7a0FcxEMSKV: H9a fC:`y6Jz(m:^pˀu8*؞8T~9hHz' $A(`h"1 #(x=sA~ ZS3(mf]? ixnk 27 "/Yi|f.<طH͂`~'z<5}d]S}>z㫯Mu 2}8զ=~La0N5j:*B(ҡuM)d.y& 22^8*7w@K1dQ MljQJx !(.bT )0!=4Jl֩HI3p;)JGT 8V Vd8V7:Gt>&8@*L3$j<N;̺#Kn+)iI"ܦ4ĈW~M8D*(Mvgy=*57.RWq^-*J/P`{ 3(kQvnKҡs[$HŲC*m'ݦ5[DrWji@sYsdIݩpبL<ཛA8BǗVda *@) >NY| :|Pbޣ `!BGԖLR $B iqތF B|lS~Tqm#H߻!qm6ւKWLh/i0ʴ5\H.Vĵ xiwgڰ$acSTٷYt,\[l:iD~/`v&6` X@N8'( 7_SÉ1ц:A\v!8;R}=E lܯ.s#RVŧ<7ACD^~d88&I7!IJXkvE$ܦ$.e! Tމt6:!J]U6 $:Z5ZjPc..];Ҭ4 OmM 96 nLs%mdnV1N:)>T@*Fiz?Q__-.#)̙텘Ӵ%SizKhٜ^Kݙ7Avj)00.5..(φ<;vX tTp!'|e !Db5&E'Q `Rfap{ L⥒I$t(F#s2- i4:ƪBIi "H6$#m7N&Zs2rU2۫UZAZ 1 HْR6 e8 !8p`_l|,\ FaȀ\33T+H0b>E_N!e)n:i [bqA,\<*'5 0G*,5WyY$r@%)ؔDoI HIQsrY$&@ S,.:sΥ_H$0k3g:)4W[V ". mN_ȫ! ]` Z`5Wv'ԷC>*Euas %)̦S}VSÈZaꦕ+TΩZk1\+陂H=Rz͡Sh݉GYu2@ڸ,quiq gQOJWNP9p\wv'ew"\N3p P] O1H\3ّC(-oUXcb-^ մ+4ct.sq /S4go:•8K\2i,0o*p-3IŤ$ϊRARb=3eqmq2X sSh%h7!pg{]Is.r7{%%L) .Rᵬ @mhckqfCL7cQ}0 Kq ֨TTmF-p 7FyD{N :ܩCdbz0EԈlRgת{$A: ŴTۓXHזѩщ/Tp ! @IRI;-*jh k6 HB3,j6Wpb3ębq 8:CXZ[.1I%IN1uN$[x!uj.*0g >$.i=lX u>nͱ^޶̳$Rj7 M ڨ}/w_x/.n1} I. "4\ ӣNs@dCy"nU I $Wj>%sɍʘu[rx$ɞ*%F08KDuۤ^h;\I"荔8@p'i!"p)$DBJlK5*|qQ 黳UMFřeѸ ;E5 &:y. 5dÓ UvR#ƚTuQ_T$Tk96tu3Twjq5ǡju:0/m^2Yye7ȩgBCp3r/]T}F棈R<5c8z#D4H4:@ I8Y*k3&EJʍ!˜UD@*}DL a% leo4Zn-s`` w8"9c394tʑWkEM]f.5z+ny4S.m;uwT;+wDrU#ڤQy$=ٜO+ ~v{MYGL]ݹZ+N cL$ P:Q:C.{vd;3e~ MPw/~ڱ ozTl#flFuU.a1hv;yOQkH뎻5}d [4wK2}8ըeZq`jxB )OjBPR#4§  ).1%IsdD) 6\Zm֒PѩH PJcY>;u+i*` $%+H_Tysf2Q4M"BazTîA1։My$Қ 8aʗ45u*ng4(=p1ۮ/V4R 7]593Q[.1"f{q =6BQ<ܬю0Y[FNMfsa#RQ ?.͈ލcDǂ:ȑBWW5*T8 nenaAM\c68Tn1$:e+YBe@B\dQΙRR Jh!s%dp (YŞ[{((յ4L=EQ,dߡ;Jh-đH2xo+ k6#<y@+bjCYNHL!ѻ.{E8EvQd!V|ɔVЦv o*W,pHs@s9ޓĘө*DRZp0F($46pc;#j04qt^"\\\ v$fu>I;;T H!;TxiÝ#IO==QK&. ~M$!(@) bvy }BƽŰm:Evu{oƠ  iq1(:eGܜH8NMy ֭֠dESH@I9!/t&րw 2#{6h7+sga I<*U}0 3 'l(I {U{UX#/0Ρ<6&HO#G\h.̂OPX YNݬa36L3!gA*ʹn 9/|K%5D֚174۔{U78nUp[>6&łb]&B@H PMpZ0mym3,i9N P^y!t.c/fD k+ĬV1q~'ERy:)RSJs:z&x[Q%"+Q#T`'\R.L: RENoq\_/%܀:556=8L! r( -e(8Vo<-J=*v(Ev;'BFFYK ֫4[#`x)9zT}Z黙` ^7aý bَ6(iנ]uMAC`i@`{<]})E]g:dNxʂp޶}KۚqŲ&- 4 \mHJL")AA@i&S\#VfpK(ˁtQ]R|љP)VPeGXnҧS5 hne}+{6L<LƥrV1=KW]x$cZYBMSpvP3<Su' 0Zu&RUu(h" z"&̐ø"mrP[;L44e ̩6vp t @"\W I3"&"a$Mi;inl^~':cu)f=bwfjZoNEFWCʯt0==.Ԇ2y/. 8"o]U0חb 0'YL^Ꜧ@\? i驩 aE$ q ihE\&BDq A>euCmIrUq0K$( /ti9\#9ZddJOr>JЦA c(=+(ʆ5B@1ө 8m\cCKR57 ˰)ę 6ϰ9 HAsK)Kz*FQ֓؍zP$xF{e1mߒ uX%~_Ī 0 alWXGEEr6Jٻa΋[[gY,|diZÊU'V;ӆqFތJ.btAzg{˓w:+&Jٜ,ᵬkE(wAQ$Ի}x8k%7N˨%݄»Gu^9mwuXܴғ gok^e{SV#JAT]|iًKmzh qVkp&e2J!CR^ OvFAݼՐ3tQ FX4(Z]= -c4VjV x6N|;]tڌ4ncOLQvVe63>A_8iv^}#̻mf]>l7[2ԴZBKs+X8Ü8MչqTiÉ׹^ǎؒۓɘ$+Pf:+X-&* z*aIճ$)IOTs\לO& 7Jnm&nó)PƎuk2BX#=Bk骏rܭdèmOe^]S}>z=G٭#'@J`{Zq`j"h}~La0N5k!Q9.JW NseEB;&I v91ŠRU%B4 LX5HFLt'H2s)%*(-rj*\ֺ5Y0#̥bQD %)Tj:e\ulYB0Ƀ 3I')lDCi=i` [=y"ւpblSuIc,ΔU\#Mq 2*dQ ƃ *HMp )nHH6K-pW;a|8K+&Mak-7H-#6qXNvgRAQ\vH%2M lskM\3۝qJXk.Hf(kst+ hG*T9ʰܹ e^AxJ\ qXlDwg&(BA3MuBB b94HԘ8Y[{Y"Gl$4 MS&i\ÇЍjHRڤDeibiQ t!^A0@dsHA>C[2Zc=iQ$S7:r26]x1!OCJJV:7T_9 궝mى 1뮭 6ܫ0:u 4+{.3Kt\v's6!L֩t kIq̸-1JO@CI.&N*VT29#a"Si%@k$ @;_b2mO>![fZ>Rli $X{:Jp9ky-s}D'2J,wjD@"HaFd#=a=i#o#4`q%g;hT오 fAݢ³U}3ϩkB):Jc[  @'΃GMHɂ!c*\r4hzcu퉻UNjʶH1Ҫm}KHv qhI@ st-mh!"H1UaDŽu"$b5a[DoCibUOL[#{ fKrk;l 8b1٠V:]x#K^sZU+tJqQp,25&iU1>n-n $! ;`RK01y#HIZ~͘v8C$"O+A IlX ? @sT.`.z#c{ԸDӄ 87#";AB;k98nfs*w StqGi\n8qݜa?#J=E;0MW~3{`ӉJFt)"Ƃi=*30Hҋӣgi"aտw.x?y\ $kmLu|5uu`$y-T1fbDBթBPn* '0MӈP:(/׆hxTWd7!azZCEiDTNbd7r *%Xu,>&QfSUKbsa(>Z}47xGƱB!:@U%BLp)*t)AB}tSp֙J q{zNu%ܗHh|W ҀzPzm>-vP -_PFܜ6\6 [U,|<-" ~>OU ڰ<= g.j:|qLƥnX6jCV^i+-#J.k7햎yBvu])塢 7$pӇ.%s4Z,\$3u'L$qw<`[4JGQژL2ثC) ̤.RLsmVٷ #1;'ʫjld󫵴LM)i#` WJqs&I2s7NGQD#Ԋ MR#04W0[ȕ{NNw] m3Bjpҭ:JKtMQaNA+N iuF{Gv8c^Jq:Һb$s;-|$:*`T*q7m|TUtWxyPyuf2 J4镩ѨCiLibw>D1nLM\S(@Df#G4 AK܀8HuAHCOJ&ۗ q;'HZfk:"4JGY~eT}̹;J*f>VDŽ{ _HP{ڙn<,r~ӝ*wد_j=g7.FXu#4zv9vYO!1ryխ'SHx$҂x \ L:ڻləxm0B~>70N$pjzn^\M8!ĤULu>R'_O\i]*i< XedJ[ڰbc`6p`h#}6&;u;^bΉ(:.?F ܁JݡͰ <7-'HD$ݎi}u6|`|t])ti]i,\IIi6A|;.)PvÌ}'zq  e5 xR@>v L>]3bCsnWF2%8#bT+RWX5U41U63 Dh 5'5B%!M{GZRuoY; BI*){"\Ɖ!9xu)*LCZs\q)2kV:JaM G|zl(R';)Ә L kub$Rt2qGOO-7LPJS`S!NJPFZs_ѵ@',Ӂ=P H($' lxpQn'.{f5"@'}(Ra&&U7B: QBV>OֈI:{8Ftc8jA2o9εt)A"i@hȬU4%, f)imU:]P0'@ꘌ*f4 N ddښDrwG2N}]IaI̥JiR2jlnU%(v# wWR @jm"f`ZХc$Ğv}$!Hqqސ8Ԕ{5hC 8 `S?D518Ȳ}J-SWЪ=:DS bCd*HjlȐe;DmиV(3iv⹧Lj i ҂Zlf&6D :i-Ų̈F6HLM.qW[臒1đ2Ea5LDSfcD&6=xdi㄰MBvw]ʙ<<ΡOPB\CZ$ N!BG848@$`\)8X8K(hFUc8i1$V5"R!*{ݽk;t|,7<3)har4_FB!+:!V$dUvCQ.ڠ]ˈt Q. Ga0K e|Fv{g>/7y ]v9R v$ `gbsXIs] 7Q3]cr74K9A]+$j9exTx83Æ;r!+0L=rHL! E h$ֹgh EBLEXig(R=y$"t)ԄE {%ANpZ@ Baw搝IS8@8x2=\$fV>&L7(f^!+60٘Y`!Up0roViX=Ϸc3hf˅L`$0sM#8Yxf>ۆჱsv# )2+j!B!Zqho&[K~*?I;u!DBhvvfٛgw024B+t-蠒)r! Bkv67Mw%r(hB!='ܓg&{,>7Z]+T/y4c{H $yj(0vL W3 \S.}hB0pC@WGJůpaJM#λ0s&}(dwWl&ˋn}h#[+M38SѨ2! ƱsD*J 4L\$MD!"NsP! iN)UjP! %AхN _]*K.7t_+MӴVg=_UkOcĴm|ߡ|ɵ`P\,'tu)q0hNYس[׿ .n6UtfS6ZL8`X{F[)kjTi͒-<ndef1ba"pUƛ{ oP'ZiP' \HV 8 *V\4sڞdX\Jh n1ϰۭ4}."..0J9(2\ TRZs(+&DqA|YVf *`!JV`)(T4Rc*%j 7T<8[96[/+Kg Z55ˊu*C7d_ 1Ѫ˱U7V#ݖh4'>L({ajE+e͠-/tXI ^I!&Kn$4ﳸ@fخ $I.*JA9i 5fYYip:2rxE%\{Niټʂtc$ :FFuJtd%1|ca6[?J-%8-_Aa{wzxǬHRNNYl晏6bUi6t>?pp$'YQ kS2jis-7o q VU%dmxB{][Bv͏O#hHv#`_wظ I/xq k\CL:hnws*4׭J(cqn&`9%\kc ИARlF=W#dAYu~ l..=N..lbI"BܤUh vרDzoF.uWG,4`H**O`ڗ&@yؚy8$ɍB۲8=c{km Ɇ Sa fbG9 $qg{Ilt2 ԛh=6O}1/4+7HؚِJ- 0 5. "Ƥ=H%q lԭ]t 3RNlFF&'zPj7GS*°.N˪pX.Ut6bsL\mU6m;3? G)p=cNq2*26$J a8U#R7Oq;+ L,Rq2 j:ev_ \{?&l?=e-J 6껜\d2$.g2`ӏ2{m fc6M bXBԞ%3ٰZ4ԛ"!HSA<<!," t(7ǂ7ǂD%B*t(7ǂ~NBR!BSoA+{7+eW2Fecx_CE+ѤNGLe"Pa ػocfp6 T6;kv.>Ƀ藿 qIv+mJ#T6)нʹ]IiZNTҪB mW1$Y.{!vkXv d,=τI9p$SBTBއ*FΕ@J&54AP={mE gs=6",+|7݈{ʏ})9KY)qOt : wOn;i_7BG{c| ȩhxG VhRt%y!Aܴ(F)HL n+8UHcf ɘ;&#b5wgpZ@i옌w\`"5|.K0aXh$QՑ$WM{a LB0Y9KDh5q*35٫ 4\ۯ)%xqotg{Br0هp k ;,ڕU=ec1Y.k \ ]PӅƴ=1T`;6&`D+x6p1)vW=șh]V| CئrJ=&(FbCqci.|Y 8\߁\9TD჉5_Iy+hن#LVE[܏9O‡bǿ#k2'VP9Vxؐb4opd.{Ol"}!!8nT]DwtNPI t#Cۇ8 x?jpY;81kE;uXD+mh`eW8* {<-JU$BXD!W޻7 aJ_zH޻֑d/ftc$%X^ֿ&loSuYbw}pN5uFP%B+S8kCN '{pMzZEg֣RQmC6 ^{JѴ{ȗ*؟{>%Ör2Yl,ij;q, l6 5%t+hVՍm IvXn\uW:.LҬ u uJ*j288ԩoٟ.ss@7ZQ`mcp!` h D f$6No:B1}OLR#5#^J&IuQrP"O$( S).. QPJLeGY#pk[(ݲ +=Un9/"R+1J #I i@:h6ܠgXNv QOJ~iP;-Υ/3 pY`x]0R *BjI t}  TF7bOMMn, 1U5Y@J Yl#!f{Ȅ)qP"sw7$(*Y  WFQH,ƕK:k@S'gd dy"4) q͒L=*ppa= ay& N RCc7#Em)Gz.WL_Q^/FwP/mBKAHdl8B8kj9aζGz1 kG\G=5k?gvӄFfHEUl}mNq`@anF1.җ^F2u(t__ ܓۆH3ĝ*#U\ˇhFAEW6U"5iD&ą>ihE|TXs^̉TQN;JȆq mh+ 6.0 y8sWqy5p\gb7ø-l8>e47ivFVΦ)MLdZ ֌Re+isL20c#7+?jg<;; шI.-%ĸ9'Qu6ݝ*Mʯl ~\BfqQ B"!B!BΡOPB!B!B!B! [OQ1R&5Bh߇̰'aBE!B!B!B!B*G %g:PlUՍ=[иWIYD41 sUߤ:<hA$'++7'vq>6&#7"! d>#a$f$FseZ𹅍!-wD$:'^#Y;Rd8}p\1FbhkKX%8d~[6Ƕ3ln.#p;(nR B!"S(~1%D{]-~F2kBTvl\=cf.+zƆa$V[+8xk 34`1~чxh؂ZHk*{&χ8mx/9ƃ&&j!"BH! BB.ʜN@\Y'I9R*{-#o੔ \.oڍ KI{q  auyك6ODGz4$0=?H$B9N!B!B!B!BeΕ#2JUWGd}=UQ[z!5B!B!B!B!BZ5hZG 0{dB T+{nÃ>8.~YLj nҴpq mEEOHNp2Ƕ*$Tc6b7.0qdm]ٶs`, K"uZ)UK^j󛀾Q=@Qj:'ń! Lln d8E $O3eÜLk&NVz"D R%Bu& `8%[/)c1 %l*qbQ$K.v!*m6l\f᰸4 TX[C;Qiwx3FݡoEy.ik Ђ$Uضl@03cc  SFLE&v)jlt ꔓ$Iڄ*[v۱z$a~\B[%iÓ߸ Ai5 $ǃpNc]xc<f'] KACD3OI1 P[b}`ް;,Ox+((($BD!J*!BhPEzl1~K6%VNkބplb"XӲb0ōրI G|T8xc_8Oo|{+1OGM&/#Pv,w{ 9nq$ZLsE!8[rڎ:q\KqpZ35BWtnj6aw k] hw`dn! P!B!B!B Ѝi !37dO>e!nIHԧ5MtrL DՌ@8pP'4iH2K4Ux08OĿZ SMg)A)zNbS0OByӥ5q2a>stream Adobed     '$''''$25552;;;;;;;;;;   %%#(((((#,0000,7;;;7;;;;;;;;;;   %%#(((((#,0000,7;;;7;;;;;;;;;;   %%#(((((#,0000,7;;;7;;;;;;;;;;<z""  !1AQa"q2B#Rb $%&'()*3456789:CDEFGHIJSTUVWXYZcdefghijrstuvwxyz!1AQaq"2B#Rb $%&'()*3456789:CDEFGHIJSTUVWXYZcdefghijrstuvwxyz?Π +B !B ! S[A!J|6;B,.GikOG`ރ[Oadb=V TtذSZwb唁Ib5t Y:#^vAO=!s2c\I]@=/ 7<L5`s]k0Fh' &l!*- AnT v)sM, :$pT:K%UntRR;~IK3uq8qpi sA4HhFD (TĞ) O׼)zP-vt؍tFK+HqQ h@2LsKUOܫ8%K*XMʒH\MJ@j0 qq*#)Q'Y+I;;4y@C(7BJJN )b,뢕1HN@K P{N:5 $8c!a+-AU$dYANQEf"LHJb! !*,n $ƈ # =QWЅެ y ܢS,Tlm#td B-npD 0$a s" af-) J- 4(GuDHtRn,t0Τ,,"Ab5☴>c`R/n, E,`(n)ݪzhRڌNşE=j<=à{n:OXvw~ף~3\sb(L !kN PA!AB!ABA!BA!AB(A)[)زG(Qq2+uԠ*Jy VΧzyP6aEu3Ua !3DqsO*؄eSXRvFYQ]:L' 'FLԙ"'W92:s<-8@ K˗e X'{&`cm$[nILKA))bW Ɉs x65RflJ;hPP4P{aci@SԀ7Yޤ7J#(JnX $Z EW9fE+(F BP VJ5Tz{*FR/1MQOE! HI "ޫ-&SM"֔$J)%5vR#Z$s J2vac(< >hRf-R)e6D͚#%(ٿCTpaP{n05+*hTI=9!J-Qd;B]PD_zbMS ؍8"JPB'~LTM7UPbAy'x37( K<@6ȄDv ^)lTQD8`-KBa0 *KtΛ1x+Z,L:!9h"'ڢPTULJB ^s^{v78TA!ABA!BA!@Π +B !B  `]PL/y6)=@jSkbg4[~0'ӛʮѰˍ1_d Vtq^-^6.6!ӕ\{>4% \$s)[pL.w*Ty9X@U+ oVczN~@Iiph$1JNzKn,`ZbscuXPp$m+"*\JŚRNJqXC*8`I@L^leNrI9EM͒9kmJN@D[s)uzR0ٍ<Z.x 3ks(eE¬ Y(4 ' Rq.-lZlnfm7f߂|F!(Qmm)CTrBAxD Th h~(uI.a}Ek4)ԡG5H#yqDٸR K&4tv8YSۢ8MX>%LnGr*\tZlQ*rsX!)hlzF> 7[::)F,70,'3뒊Px5*/Z A¡\pRaz,3w).E@Ta'B*3elڒd̀DlF`bBϱFªr갣 η>0sj`Ad5 f=d)ea-( Yf8op=r 9R4F FmSޖ*>t RSuF,=4MuRX[ES)PHD0]J0 (PBqXw%)v KNKuMt5 b%=nˈ-p޵dB!uZy":-k f q̵ڃ(AjY(PABA!BA!AB!qʕ5 )IXxW$\Ӹ|5lUANLu*إLĸJwsX?<C'H. lf-FcD7:'* ԃZ͑f&nmifbU4N `w^ҝLfXWHn׵{ ({9Spp)$Z #,:gR.J\`kxިf8چe'#dYc`tlNX\bl7[EԬ?CХbiVm^eqEWnmsYaZgI:PNwL^L'4bэNic[&F`lB.x.卅81 O_$@# HS.UIm$h"d!ӧ):R2a"}yY LFUN.+}, !t J%! R8[T yD#BQvX V5)! cE"܊LQu3)Nxڐ6]:RVeD9BfД]tRV|4/[CR `g,j|a#ҀI@Bj fsIQhӽ_cA{J@qBVڣ'T%BP\ )^sXY}}a)BR"ʒAGaQ^Xbz*E1p Ơ ARJA!BA!@Π +B !B'DnPςJ,=:ԛVVE78in| ]IʠlDQvVm͇2U3%ͽ;{ga``ݍk~BG'rAoVg 'b` S&<,l\ܝJ~R(әl/1( Ni$s֝'ThpJh`˜PJwv^+$1d.D$]U q䠘R; $z1$eU Jr@$$QB*V XNVK(! "BA3E"*ACpcp1nP"DKЈR*h m Ꭵym-vVMAӢ's4j=}tr1.{*ޫ{C.DT?#k8v!ޥcc o: ܡcOS18!0l\ցw@Ԏ,4d腁q pcow=w$ Z  5e#)#U=KmpHAspQhHۊH0aoOU`9j6>t]`[!tRbἀzn#恼S =l02 (IN^Tc-vq Ubbܕͦ#$7$Qe7J$MUQjX"LBb2H:-gbSh9-/hqÊz#Ep{ 7ꜽlڅK rJG?#fwLtF)UYL*a,pA%ePU}2)%Jk[TծFe0ewo,'0[ A"fwwD=ĈqRK_"BLׂ&pޙsgGJG=ܤ^$A!kZ e/4]>p^|!6&hn!" RА\ۑweV`{q \$b e> މ q8;w# uB(R !B ! SPLUHTcb֍0&PIY-d5&6&j  UN$ 81Ҥn)mC [ Vû3ghCEx>Svq\YNפj`pcDu\1˃у[!؆0; t:WI+e#e\z!Ιv=׊ m˛Ǥ90v@|,Gk]ꒋYZ_vJn{܋HpE^*)46D6ahԅtCpGCL0XX׈i^0q:7Fc ^ 3#9cƨy\"BICn!@o@vXNR'tj$Rb{GG sAܟ>.&,L#QC8IPn+_1шQ4q[SdoԸĝv U<Agb8 1ֵ5 L-E4/ҋ.>d/t%o4*CQgXܯ9p83ͫddp gAdmsN7LB08JR=ғ Π,\BhZ$+óR}OU CIJ[*ji"RXI"eaa?ѢHn=rk2 ֜ uG]- @j T֔DZ[UPq6I, wNV@TA@&' m쫰o]|eu*ƴkI-&$9͉'S )|H1zNpM4Vio7B !*/28pEKv0fnh BvD6V қoQ{'-$HV7 ž};;:Ib5^hUkX![Pb`;C^k#)lV6.oWo;43n8Xc^Ù^R@p/@=ã;O4'ԓ* :R !B !Π +B ѹ Uzt:u0/W  ӉR:wKط#*w '-ع.0SG'3Ҍ-׊dHUAHTn5FS1q7$6nwXn#-Tb8cD0abevaxg+hb]%Fn!3#ʮa=ח{Qƒ]PMM`n/dY@=&|iX (,~#a` Ö$\*) k\\`*.hiUkwPqI) 85I'@l4V_)WBֺ;yih5+5m605/hhatUbJ"9/] 11K&вR9plǥG -'8mP6䦋M$5ʩ03Z'En :8Ŵ fZ`\Mka# D!, HȲ0$JWRtT%Z"pY B\KJ%a DH$na& !EOoBq)RKF (ʰK%s0ɍ=dzN)%S@+|x'L0vx8l{0ф"}x}+;FVnT#>ÂeQ4lsSi`ґ%^(6YdyS*qCZHUK Mꜧ8 c) ͒h9Xp5EMF.#ȜWI->,D$ԸˣJoF$fq 3%ONC<0TuMü>iZKi ,2(UޑpC^j+/q08) $ZH ݶAM cAk)UFx,2A4 P몀i[C`E Ui6f< l㰴w{1 ЯK3 tlg{'4yB&5Y]tlFA 7r:$,CcZ/j VoEYu+h8ARJA$Bx`S GTҲȄD 3>U@"n <&@DlsSL'sZC/ְN& 鋁Dd.PX')9:JOr8)SR+Cp˝Ζ25ػbq̛XeJYh.$@B<XzQ^!t Q)1eIfɒ PXs l^ 9it$ڔƗ`i*_H*F7- mUUq,wtg#MJQmp{UC|.IXN)Dج9|[N^Y_q~Ӥb89T4 @qj xct=a5C|'/E,2K'70KhcP kK4JRI{af2`94vXHp[Z >t0\e)KEJ,$lTASYm=EW90V<_ 6j%lb%>iu1{Jj#Pu3>n;P$AkoyR[( r"UbAmW0, Fr@^wyJh(I{ B-j #J^xq&DxBMu'd+^Jdkd|$A'DԖ)ZY e- C3 U&tM:vN:)zCu@ȸLcȰݖxtiBa򞵂P+rتM۰˒2K|!e{m:.9# nty&#s6CApFzD0;7( Xr PA!@ΠѲ*z>tzrnKhJtq$7ҋ &N:LT!͒"as=ȮbMwZP ӺN&1!lN-cqK1!x L韇a5ĊCEx,u`6pNB ˣOaXA8 DHU;j"R:NTܷPJXTFg*IBjU'=-= WTivl`m6 5pU_4BxyHh1t[p `.IS2QLGD-cx0LbDXRwIn3k p&ĀDƊay蓖QhmVY9xS1F`3R1NW&6P $ze vpuJRc7h|PǼU [Apm] )UTVwquHH}CP,8J_*Flxm f戞'yY=p;z8wsS]ByN)ml%Ԩvi}V6&&niR ;!6KgN&jY} >gbERMGLw$w$22uΉ#+$qD )y'LvaOJ7 MjPRNMﹳxkA{ (\㤥%Zـ7J=Z!9zJ~ %Z \B*c+GM7'@96`I{$7ΐ^B~1:Kܱ0 r~#] Z]=a%KÈ2N $âSZ#ăLN\dN1؎ ?=,+Lu"htt)բI b@cF X+^a>&&#ėEFbâdZn#sÁ: a՝Rh:/Dj6LZ5<<P06I3(y)@fa6 0L;97*O U+Ϊ'rUPb7?DP,G2暀q]r)lܔtɨy"GY~4*>Fbzs%H4⊃ES-d58Jo iZ-B|dP7"r{Anѣ(a5*8_HI5ltMBbfQ@P,hW&Ki99Hd%UUiSBe0eJ;RAҊСPDV70o)Vûڔnb`lw.*n s.'jҤ2U˲K (HV~ڌ3HFMtXyEٌ81=J+ 35Gc*7)45抐[:-P\s)ͳ$NGRC$4A(5ht>NhZ.h;k(AB+\ gKq["n.=p̀$dmqmtrF1Jr!I{Yw,9&HU9 pH-SaؑN֘.m4cfZZ& M I$~@콨>PGI3qJAsr' /5DFCPր9bԑMTNsG~^< KR!7ۂ+]~]]sky r*)A<y=b`ےf Uy,V3R(Oؘxx{Hl׶{!䈫rէ~UeokqQܗ0B9nʈ_qL7[顄za 斘*Äƪ-zscYctlxm7-\3cbA^кfNn6[PuxIi˧w@ upשEA E *49Z BtӍlMjR'me$e姴f-qQ݉inZd @5Ihx* &!S0p<&`&-{AcC+Xnv HnbC+Ɗޔt3r> 5oRFtN&6&\QF6! U!E#3]j vwۊwF~Ui$kã$yJZE;:Ea|##P4KyUt=7ј1p0_=~;Z~ZLء~h@@?'iÇ/0mKuM+8^KLR {dY- V dq,v%Ar6YY_1fDpcԩ~&:Eţt6S:+"6I# H@|5E[۔fmZ.7NPp ]rJ\H0A(yayN# iSsHpQ Pr>T1G"ےӇPqB3b$FFA"B%)pٻ,'] S9% $ :# #rrBZꚂw`I2T[ SpYNؘ;x*A4\v,ލ66wAX$@R Qyc+[OX-pv&V[Xx/W?z#1p7Pf2''Q91| ft6xB$AZW!BiS|Z"O${,lG[|!ܭ+&|SZ'A&n>Pw޶G!$t&9Ṁlxꭠ"l51F;i232IBZE:y&l(  `{Y\lԔTT %.;.JP$3نahu83Z10O(E>Zu4S M0*~F )ԑi $1UNN+c6zxW5Lf&#cC}9{LgqJDW q%9/RIϼ#]:vHe8h~14Y:4^cIwFKv)l&`~!9*e%%@H黿]8 e6&!0\d+ZjlT@Ͱf(L]7w]8r0F]S?ֲ^M3[f 5ڔDX vKRBhJ] YN={u3[**N#T @CD"UE 1rkˍ׷R! .i{Fd@pA0ncD}^?H ؆3ZD>OYKx!$INlI|k 1rZc;!s̹&V)&OWѥW#90fs U\y [M.4I/2tI"wP$o#]Ua&L%c,jaҕr4S!FhƩ[+`HN::`q &GoƲ.nj fBIC%q0OЊ ͨ2Ý6wvˠgkK[} BEn8:b8KzAN)A2jwhQ߂iMٙ>PR)*6HЋJqHh9FNOf#(MSzi";;EN7PDfc22RDy; M 5:B>ᕭT,SI2֒IT;X)Xܭ2&F0{FЂ .Jd8ibR2Nj, C3"%Hy& UBBHA6 50fjZIX'r\nNWm V4I(H2 .;Է; *Vd#kB_Fѥֻ\G Ox."h]/Uu" 龈a 'm !LzAq ,ly,<<.[V)8X`74Mb`aKGN8L10GM)zMawm|Q kJU>Sqs6Dl 䵵Y@p0 6 nm]ޔQ `hk~mYYxQ F<gmԥ2f}U@h9uVz2PR'FgvFӪ{ $C`exœWτaR1\q\p wci0ӡW h:Sh΂F.;ع9DzQuCBq?Is7EWd5;GC◳=$M9ES"%GTM>A:R*X72,A= s_њjшE+BFݸ`fhoxК\=F.cBmP$NvG65%& $F.LU=ĸ5Etظ8XB)=k H.\'36X]dL5t[`Dپ 6Zo ʜ|wxl˃q+.#33 f~!0]a4Qp8m4q%*U벌bRtyf6 !dTzΘ\ُLld[1d ͗YT 00PC԰N3^E}(lqFI h8f4)96Lf8%oT;8ci&xv#jъ ,79h ݸ2z"ꄙBwZވ6$ C% ٙ2쾔YRp`:w: v'80ݴcq!b.g6F2 lMl 蠘UbĪHءl y7v\T|K OҚpfnaPp#D*SŻ͎;+KrZܮ-")!#YV? fHX"<&}Mu$ 8w#EN&ZD>`}#R)ah4PUn &[r()@)NZV>%%Z x %L6 H$Sk8y[^ɬ)NW`Md!:T}GNgˏ5"Jᚚk%hwҜpim^g㹘@B)K`NbH Ѣ6<IesѡRi.pmeI_EZrȪ)- #zme:C E6xK-E_%V@'hL v5ں*p+I6PN!P 9E~MEUcZ潴JrYP-aވLCdbS*ZI]ܕ"GI0Or[鹏h Dܩ+U` ٴ(.:ZkSN[MCLY"ВIJmfKt^Y,9sNk2 e0nΤ"& )ah6)9B ] H;%M6MSejjh6X|@ER`Lz84!S+$ z:kS8zzd9)5JQe%JsHHr86̧ tvF9sȶ\8 @TB7I hTz:Mg[q\ (KXЈ7Aza e Yf U({Exbc RcF !iBL)]M%W;ˏVD U>QUAn*ba#7i* hT SL *T\L;'[ Pj `&e%7(Rɓ(iHOSCa1{39tVmL+i+B1ST LЦUـFVu@wOoVf9 sѭ!0F jnc4Z\KsSj[ fǑQ2hԝ9!88tpۉ4NZO|9-]ʝj E:c-&pS`%@PL+q0)>D,8l{B!qH/ख}40L ܮh;·`:j#9L&:,WWb1Im"ԪbDlqP@XѣNtF\ԧvLygΩWDIT6u@&aACXl^Ghn'@p"t|LX  7^t`g!hd@: balH&  _Z 5Eh> @q S6)Qs!(%%9U<1 J0r,MЛe(hHJ*4<fs2N0t)@'̒G6MKc5.$Pd%4U|$IԬ0hO3rMm( %IV l.V6)b3Qر@x5[<8wֱƼJ!.V3({SoVwD}(O%C#&$&zf.9Ėf1Wd`{\Əu;o }.4/toI mPJ[sŇ,[0 rlA:@ti)Mm 72tMDϛnRӖ:s%t0)#]Aױ `q%-ch-6-, XܧUaK_iJd3ܜFQifJ{F}0%lF;:C\Ύ{L ̸oZt,L V܆aq&1E.4H$F!KKsdaN[l08Cۈ܎R"c 04љ9~ɭ`xghbbc6b3 W$rӍxq$0NuOV]OYT mUwi$Y!1)t~ZtTM #R!wccKoXz'Fu68y0*|Vt| ֙[>Y抛3: yi=:DN֍@Ըi$Gb\,^ =u7D !\(։trXlWcp:>)lS86;C\msSePB'uŧqtK&? qlǂ\,jIiE8;;6'Dv#0)}n-c#ؼMtynN۔k0{4;LێV~#2ΐ$ L0K )hY&4{(swG#3}SpL34<6&FPcC֙dƤJ!N$F|c;&E\ PaG$s\fAЅq G`_t8 m͍}ۆ<&cM VF`XO9EEpԦS4A ÄMG"Od9OlMvpohF<5@0b.F ]8L4 ;9t'`ⱸ/gKset +bcaa7ݸx<<, NjXg nc1'z<.2ֺ =L4̌OrR$ܡ4I#Nk H$sJڴ8X 3czfsrpKIqCs$f t4{ "AvR"zyZ=h Fv{H$ $c״jHXޚY,#(vk DGSJNEdu*6PR+g;lHn;KiK ]t' ȹA8ۡ@T˷qW6-3*VzH s R , t}Ga VT*5i?bѱFc(:`zS ZPv4ۊA4QJwI) M5`*pm,8 ZNSE*>@p-.&Upt[ .DTbWEII5m|nŽR@$1Tb$CMɠ!H5:i*aekHp5O\n^g 9T&ǁ =U[rRE9 Ή 3N܀|bJ 1 (ϵC!{-ha&63ʭs9gG~V9?2#aFRw6)Sj+GNR%nHLvܥ+6>D i׊{~ܬMhӚϔ9F=oN6g'3V1E`?b_B!zf%Ѱc!0 J--4 ; AU=iBKZ]ܱ1 p@ d O *x {^pRŻb寂J“3 ӾM!x% 88ma>!K~#]!KB):,c"ǓKZ.^>ȉ"ǹD6!\<4X(@ UKgޡCA0bgCw2c;#{' yG]l j$I͖66&F=&ÙYds1k"m"CrLV麛q.{ t˥)mZ&!fzњr"$O~[0瘙%v8.Ĉ1zV As@M4,᫹Mai>/zR3CfF#\ֽ8ny4.kz%;p -bӹlyx.+sͲVtga0ߋ_H ™t)vيIn-y7^З2, p'|Ts:ւ@JR"߄VX8o ˉ DŐ:n/KcqpX%CCU ͊X}AL%jkYC|&l7W9Et$aΫyWGl~[< Oމ0z.v8{"-cIsɠco2#pCنvoD{5F $hS%Nf~뙛Q^FLs:@J|,LF6MqT~ا w+~J˙y7rc;1 &t0*7ytƩu*0Ɓ.إ-gۦF. -CcsXIWQ;^:30pDWi>6.lϋf>ݝ$7Է,v3gDK&["omfdO=V -#Ġ.Mn0an( @ )ـ0 j^ћ kY4fy)`X`6 BZ@4>}J:F*mEPs̬`ƽaa`z/^p݈Fͭ8R/ض=s sD0V}g;A0txoq0;Ҫ3#PGn]9@*6Ef6.x.WM`n.88A pTat CŒ]N eRq0Hؕ&4;Fu)1.ݨ&iQ C˜X`8귎gHx # ƎkMVā@k+3amH{D$5 8?, ΄5ͱJ"<@;bEεlp s(xm>lUH$ x?psDS.c P 綛uFz/{u~I2kkn vAsD8GMԇ su=nX/Xe##-9"j1 k=M} :^ִ ;#&)*ˎ@<XKeЋqZ'{צap= iGc8b},I2CVp"xBs > ݺH&fBu=4 2\'d1zĕ_湄HW NڴPQrHd8G y&ۖ SUcA{Z2&<&7oYo.U#en!gzW#.R7b; d͘i k]nLqJԤ ǥ(FUg ܒ&\OsUElh K,3(G$&VIJ)uPxߪ|x'FӔ#{aTNFoNhdSYwI>ӂ6ףa;am[&KkzչޒNUBwB J@uJNt6 )tk6K \lJ wO6Ɨ:&m!Ht82ֵ/lEU+M9Uc4&GL*,%; &GGìjt:ɂsxh76[,1IX] 3 Y܃B9= :ꂦ( h.i2 Y>-Y) JQ%Dk *yi2n!p%* "Rʀ.knYRm h̗ 6v/ MVN)z@ ivV?XTy- k vMMKhiG 0Orqr8dDʃeU7:2EVV8,l܈1k]6 ͓LYPZ(uyDN;9qaځ1zH'b *1H~/L.!ªaV2jR`=c`P6;OZlUVTT&> P;3ہ里tn}Y^Ihq`TX0TB);!SkK(5^$*eƆ$ ; *ذP`)loV V=ZYO(TVm 3h;QC5S$^pXbbZuW.q~ttTiT TÜX], _Iܭib]]e*"k cCNʨGLX_D@*e>=·3Z(Ccb%*„U64blxYC͹rB-l0׉EkKJtn0*A PJ_)`%>)G6-bF JP)Pj8u;jH]^>MC)(:Q30f9)sB6PK5ka%a0BR.dM:[D n)Pj{ᇳteF`DqbM0z*Ӫc,oD69q7+a;3}B"g.#pWkBuaâ p(c) "RTPL2S<>˲++P}ݩ KE7 GLb&v!vY,ˇBybJf.Qb8A(\5ʃIk3Nbxby$ p n`ަlseJ3G Rܷq9>jR,2<ؑ#Q)btaas\lQ}6cUrK -*_3YX g^UOfBE9 &-! ~IK)l4IL)ubU/=UQ$7pc՘Z^|>gȭa/g_S?Q ś@OpQ^I7q <X$O]f'z lP-;KhY'd$K¨"{+<&*rkkYkۙE%/jPtZ4I%$!+lk,Әr |a~‡,nRw$)Sb!hbZeܱ1dAˊ6EW͓eke$*q _:`y8f@h͠-A܉x d`CcIm JLU!<>2c˷(vlL 6Uq`4|iM@e‥V/p1ģ͔id{ $kNF/F.suH;tp1ڳ1sy.(Xbs ,aqIqp=ZVfgVBNlhdk,3f^>ODn$=") op3Gȓ;/Saϛ׹6ʑih>LB -7H~ 4iew`x~1.}XHֵf#Q~2ԮM`z%S-3,(` bHellԤUP9o@dpU{z?A8ٗf&\rsYpq4][І#لq&s<d*p#(Jr({{,)jU;)a6:PD8(HK^Ӷ!v;;'  Xx` tb["am cp:ִ X4^ʴhe:NqM:b¸ u6խQѯR&`E,[tw8QWE߽c3=fV/HwHo!0&l] 'tse)^%G@dHMO\\ E%>1NReY9jKB`eeKr1088}$^C[cMқr Bs׽hŽ.l/v6:D1MG82 V1$q)D8ev*^XDTctHGiPLS·h5Nկa9<͸$n)ImMgf) m *MsM a@LYkd;4jqzNϤ7xgqWz!:'J9FmԵ=bG7$DlmFok Hm&[F)L[t*:K~ ı-7UX4J5XLό1RQ6n*  R (~ጘzpM0Ai]aC  %ij ;@e<m%1=LΣ`D~WE1ap{"OZym.!clfmNl2 F:x}/6uXn)AHDe]D0rؗ50tAC}=ʐwsͽ) g:[8!nc`V}X};b7ᯘ`4q[6Lf'ť7[F YMi vqlU~jaK }"ɀ於AwٕWF9Y4ݤV4[ш8 81%ؘNc\@h~bYYF]1x@9^F3|E̝-p~웈-tya1PjN^2YpϔGNx9ՇGU(ޙIHW7iE3q0[%LXԮK~Up=Ft~_Xpq@l\a4tuj RSZ S P65Z22AoIq  (X3t22.o(fIasaafUT˺ec3[΋2'TiIp%BB&,16l;8.odI7!+f$f#Φ Q(ROEPШ2!t#PQ|Vj#*q|" S H5i1#h;DN D[6@LNF0@yeI;ʗà3&t%ܧ %d1Տ{&>'ad] ֎ XV6#NjBLͿUD$EP.Y&eHnc!TxBBq.wrTv{lJ2ۙRvXtE w.(8$`$Z;Fu#ЀB@&o@S5#]ӿ_]KmJ3$K"B0ا ҝE ñTQ3'JcQ<$\T4 ԥJ j-h(4!t=>)Yx^k= ])EV0} &`CjI  A DF1d jPuw[Fi `LBe3ZY VTP HqAyhAc39,x  C)z8*g`P4JA)^Cnײ̜;`&\LIBy ](QVtM\ijKK2r7U1P1ÊǶT#:r 6؇HXR[!J(Nbۢ`B7څ"}!-̬2MTa뛈fTMV=AP;5z~Ki/f";Lթ&2s⚤|6<nBV2ԢoJT{v m|\)!Hcbi<wO;S)i2aq L!YTY&"9 J*maI:RZtuA[) Li߄k\U,EC1vB}cٞ{I}Zmӽ[i>~*v.8HJ1‰Сkֵ1#t:Ub]_mHcژ&)3^K"fʻ5Q)rު%s$pNP5%M&,Vu0Pr{Ĭ7pwjiؕL\p%ɪms*o<M|JT>i$\5VᆸheVaMKJ,:!nxɤHf'Gn.' Z,g ft8H;15b^9x(NۚE]*T.q1ϒr9d) # 0k-nf?I Z`3 d\ȒEx #lAzL!ůvf N "_1& sLLqY k0?."ZވKT74AZ 8wG]:)Nd:e?LMPZֶ MzKfv_\LC[*$# V q:[O SU-sd=kBޓ:\]4ҲxrJ$j _۩^[v?ݮC`tMjd7M lD<΋jk"Qkg&oF7ԿTP@䊣2.B) t4Ԑ']àn.;H')c3%״Lv5FFSP  )b1unK-LP v ZAD,|gXc% IBp~)l8ga?L<5~.1X$$ĥW46h8wR"Dl%9}nM϶@%bz \^kc ,+ GKZ!+UGt'ҳ9EgEl!Mu$','ZL ok g7ɂ2810:F&-.!X9`mCB z3usF60Y56m vW *3+Gw4IT[:7NsHtYؠmkൾ1 ) ,ЍVCqX&-&z8#33ri: 8F:+tI8p\A T>@BNMgxXUud,! RMQUѧ'L84+oMơ%a⸜fA_HmV $ǝ!Λ%B`=K' ڠ֧&ٯva2W&{,gn $ 4XfdKM] 8pe2J*XSN@L?U*>+iB⵸m$Sz`%Ӑ9#$&6T8ք%@aN#d kLN:$RQKP@!QB؋)}d6,BUDE肘 e;,f޲' @FI UCHFqi1HWh:F 'ЙsvGQֵ$rZFv@7jqV2}7{,~P6;{íJFwRɊmiRXԧQp=H5{GC}(+̈́FqC5UY ppo6.1ShÌړ U),N`Sn( *ɐcEdw!RnQ4~F}w%l DT$'°ک.r-5$B`5y^1 d 7L.ӠULlT;zc}S 5J(B.a7-'i6@UqAXaۘL ;ٔLMdiZmr5_Py[OTCY" B(I{ى$p 05$ڃLeA*<S34E3DN ֋FaGSk* *- UB*9;Jm':Fx0`(%6PfT!;JsЍ{ܵM&3 U} !7H;\8p1`gYJ4JQ^>r%CȣykmqհiAcXR%>J]Ԅ)RZBRkgn%I)QcqUTzB/N)O*u)i 2T? <L4)tZC4혉>el3Z?QZ =ʞ<#y2L--mLS" -Sh;,{5^r$pNuSMEF. T Q jB !"ut\)4Qcy(eZҁ&BOb(Hp#CGV 1;S/,oV 4Ѽ\oYc KbT4j'U`;;dB`InMD֐nU, ԋt纛X3>I0Z_#A.V!$IܝUfjH't-XNFtHZN#x[:0ۥp@WNHy6'Ì1Ԥ抴=h[m7:X(8 Fw9$6eH4L*\:&5z%>]ϑ19>-O,<`Sɡÿ!&]II H0%[L $pu)J= MAX[A:VDlbl4StJ~1 7CS0殒fwiQVR^Tt\:]yN GKvbFVֶUgGmgJ-'JC 1au7ok<'Ըh%*F60#f$u:T UҺSN vAez^|.{%pjN_ -!/9aft<&gr%%.tE 4[KssScQ&ItWt.Hh"V<9w>4\KFgCdoq0Q $ZN sF Rb rݟD}D$m1C^''tjSxppc[ު\R; Aޣ;<8)•I2GUU*0q;F9u:՞bN>wޔdW073~Ϟޖֵۇ<#bt|GF|ӹD ,lHKm9]ýdي\-Il9pEGbLKDyI9F.a*N1-7PvN /è0ʆC9! 0_p 3oQ-u~7HkɈ$'rn>8]5vE' <9I uZ6 nɖfL8#)JwƠ d#[|.1\ hukrٓ9Ĉv788͚`#t4 ]a'7d#eWa^ZÙ)l0EhTCF@ݶ* Cdi(uⱝ ph&Mk[N(cN h-]AUL&c tW-q}n)"AO%9@yb^COpw *G$JH{ Z]Rm)k]Ho:Xր+k:97ppb/hGH~&+DW5fAkq cI ; f%XPGu*R]fӏ7$<>;`ˎ^qqȇ@"k[q sѫa0Iq4U}'l^[C0a 'TCah? &$g'P'd ex_AX_gB{\4Zs:^Fh`pPC 䉁s&ctM3Hٓ@+:hrY_ֶF RLcQeFlVGh{F!]4NK[PT\'[9ZH $/Z >=MzCf}BX 4Z$OIk&`74P0 []KpAE$<<6*FgBa3vU5 Gwm mYꩳ(tVcKjcXGΖ0@tұ3[Z]> KWGјsDj.q88n[c@~ Eѐ9dtTC:d$զgE˂0*8:ZfpCqp8 y;gm AZΛ G8^abJ0uYuH%IY^ⱘ=JNԥ&#Hs]Hꬬcl}${^-5-K1țK6Fr{vX=Q ӵߙE Vܲ减ad;#\Z'a&uN*KJa7:K:(AKLv0;@qcz NԤu3(NӔ RLmeF.-V4Z 5h$#z7c䔫h]rg?2U:uD1U2ۊlom2[ SsA ht :D! \-mjM5(S~bH2V h JxKYBU;0b%^FN^UR1W p"q6HUQS$~LHt$cC>+IT{%6n#Us;YK+Qh}3'pn`7;yxցثi@t{$\MM z1 idt).: fTD{ "4RI6O²K7+gIIkjekhڔZrR2 Shxk%`UNqPIH4QUU_Qͨ+wI5dg%sIJnȉZ5*hEnUx'B"9Mݹ2IP<}UE[˕k1h %FSEZ e⑔,~M"h%FH7RN ǒLB*6om$Z݆Ed8[7}*UIDjTqU%U;VL)N@k^B٪Nxw#ҶcD #s̘$"\I,X,@ g780!oc3 e.x ipFFBS2eƧ T0I""RfӮN9x.h!VNp;rp'\+߆\h@36ܣu`ui'(cdkr$_ h*Vt~W<8CE,,,G7‰UO; *&XƀZRm Eӹ3T:cAQcKiM*m3]3=(p9Kh |CፌP)10;W h9,RMҎ Hw-9nvny(Vx)Cm#TD ɏy;:X lvQ+P4p9,x(0!K2N ,"#d`ctFkPABHd"i\5#qls\HtjhQ_2\OSIm7k<<,;-mԝ7$8(*Rbc.n.8xE(b|PeF$0g){Zf {%A"9Z2p#Y{3k8oC1m9mn#x*d s\v.oxR.]Qeyh7TtƜNC=?<ٛk LLV9Npx'UK;vXRhLLZ5@kvSjnp/&Atr} 9:p{gR 3T L* vl6#ki4jm{%E.q72{d7Rs)=aVLˉtby.q+UsqH 38oؽ# -H\ga 2{b7ז*HيWPԐ JHL\a;;e%6<a{1f" ۩nwzZ!Q6{-O`l]c<uvG!Kx*߲nI;L,v+tᰜL00݈O ୟF' 0'lC1ƽao0}C mS2_M15(RRc@Z T 2gG"N$;3c4DžY8as2 j=h I &*0<@ڍ%',.` 7POR:@+bXܵ7t|SU~ؘϔgqkfd5͉i)~s< Ā2=v^hh,<8 weڑ2MtL#a?x%Xe.&+,,\^,Wkp<:ھ#rنk'k-a C =7B[BSMl\T@w@.8sGlazh&N1qZ o0fts]p0q>0kcp 5ؙ10x)8YpGX`;Vt)O46% 14>t3fzPp>|K> i)We/1hdx#P$1Q7zV#w&y,:J3>BҜadi=ճTN:x)5#ud!Kh1(VݪSiW tUr`%y I0Dk^ XT`ֺӧR+BsC70՞)], 2p)vӪ߹%2&HI 谖Zhef$:& L)DX;ZbQܑ*s^w-Bmu  $f栶AJhR4F(ȗB'ڄC)2kw0 /tqh@*PL +3@0!;H(8e:" *&DZ{VKb$VU9+{&ekdmR(f5Wr3P&D Ee2QfuxL&:#.@u0(&JYhXfuf6ߕ#K)vF\wGEa޵f$YÒtM`A'z7poZ̠q)A8*hbEB:"@[n11Qi|@m\0e72;c/pC0^i 6Rg֫u]V8mUfԓ*8*MSykjZTTw| O6R m:"H4"zqTRAFI ص6XEL3'Pz;0:lT/NJU"Q0>KIGrZi\{.2EdX;D'ҤqO$%Ԃ( $$yukMɱn<]rO'0MG;3 F&bT!JGC('[ 6d6QMj]ƓUL@% aA6Bt!+1CUhZ/-sMx%>Zm>f|fLp R  .Ge'6g;apȄdub ! S]ȝЀTqMShÊyr7RCr7 r%.<uޡB\ZYrDf!x3;k2UNj͓L^\Tqެh TUj(Mw{K )O9i 8R;34Y hֹ^gkHM= |Sn2O 4@@Tb[.E`rF)Gr}+q+tD0/lT8nuɚum<|jkOHna;ƘBDc۠I㦊TBՐ +tS"UiySʂ|S7Uӌ >n(h{  Hety+ְD`g!d$9b+,RYƵXX3.3d4ZVDkrwjco.:h!4@])R@!VăJ\'ftS<Y@l װ$RiUq3YVN3GEDz褣 !(&!D, B$zv}蜗LH!TąKe]<cty dq0*L6&K%1>y-Xk)zR+~V Z)lgQ޴e؁Y eCsIzSb>0z=Up憃~(z[,13p̭rsĞ%_I*p1CˈnEwLI h1-}Z!D3֒AV4ĦRx (5t\V``ݎI(s.r2͗(7&K 7fgp59'=>UjN&,&lҚ[HЍ\XsE>2ԛ:`t H5I$O6R*SaLm7Mg=*NfK VŠӂṸA갎.+#anNhXC_]nXE 7,A)ujl(ڄb9f[c @O{«lp z|+;Cfj6d|I\x:3e.vb@nVHV- Zcz ЋThy:3&LItϝ2摢v ƚEkNCZb&!c/eˉB7x>W7eppp5bAX4Svas{ȡS1X;0xS!wD&ZFڀSy4g"LʈXm)zDfll09!r $k0o~_X碫tr<8--:w;N2ǹZj &ƨfǣEM;5ޑۈe0CFp-sLL-V!# 4o`q%D_U5R 2= ,otJV )xvlG׺V'K<#7H3\}ޢV,sy2,Xqn`Gd&,[3>@=c8hfI ^@|sKQCrq %Tz+L=9;A0gN6GMwVxt.tf9 `7PUaxFײ:^Jv'=.Di |L0&ޖf6m s9L901i\pӻeQiv9&HNI4 ck ..Jq Zo;]ϣXC0mH\-@4hzu7M7]`rvR,NeXjI(A*\(kbBDm۩tmP\fJ'QV kR"7,AUHKqp|L!M32dK @EsZ+D X:&BO)܍Feԫ "p:[KHCM<ԛ[Tf%)bqARԂ"!T 8"wE+0(12Qj[z F.eP 8+! rN:JH@BWTЀND|Mt%7H)u!++ܢE,:* &7 nESu>sI4b{]^ARn&q~Р3CP"l!=:J` iA;[QRrK$IU\"/J[,+qӀk MkfH4%D{`gm6kY ,3HZo c .]I7PDVtrq AkO59ZÄGZ v6Q(VoZLCjz6 g0OV$)%l1GֵE'TZVT5UCEoVX34K5_L9 QEMRʱhfc ! O`-Ӷ%p'PUy9')bKW5@&@ԩQ\(ST&EzMg4C#1AX*7ЎNhcXHJ{ZXuM+ ,%{@ N SYZ4nSy M\j0I 7(೰p˜\Q}(]  &IJ ^|7MnY0 Jlp0(uQEaW7 1M #1 6y~z' dCrFVѪM7!s,-vu&u&Ac RND0RFȍ@N Xi9DžCmSNŒFHED6Q[2ƗbJjLM!ӻO57lB:gȒG$tKv"Ԅhc.xN,@fFSHF*ɐ,s^ 1.j‚-4rBWFLAU!v+do@8I*9Gr N8™6p$,'\69@/{Zh@esSt; uX-?H!ExM-D6ѩOѯp5;iCmct%AY! *63`:͂88䗺AdMxA;l11_yQ*U2 SseP$i8Vд)7,A c(@'T1Iko~I;nV 4N G8ot}a3Sy&krKs{X#Kf^ H#"nppF(*ZwF023pТÊ"4PD@a9PKZ#' ͨ!qCT#v@th :~WisLlPg9[zif!mTq7)Ǣox~+D [^(Ho.{ SWavW Ŋ4ukR"kNHЩӌc k&1Gn1~Ab+W5TkN0L>Z ;slIQ/+`>MI4I$U ^ ơH)YM|6YG3.#N`@0`hk״x$A \xCbet=q-xn$f,[ iRj^҅0Y $ڝHS4Z-AJ^0; Fͦ ৤lC.9ZR+Ԯf 894uOq`pTf9n|.q.$e{l=p#1Wk11Mnm9zV SgGhn͌45pk] bi/4sf4JmCS\f/; Ȟ)-y P슱 :i(˘%./Gwl4ЬgIuh{1 V/<#7GX޲0cB AqB9#`$g=;CSVsQNSÄM~ @iLH{I4wA -Z XTD@6( AէYy  5*+j$ )8nidTuJcKFnSLS7(ɳVʱT3IDjn"^tlĖ<;; kNmCbIO y()ܤ{9GXܵv D  UHI(:rqW !8œRh5%7Jk 2"TիabzE>Sme"U4NVǹ*5I 0H< XΠHeePbƅWE:ـR֗ fu pi~hI 8Ԧ-ճ4C{ZzR78NQ#Y(x:l5Tlxp `5K3X+JuV!g!&Z""ʯkLQekKR-1C*X6E);(:SWUk H1킮[+ -Im7MrY? ݭQa*dyGj C 0.3rb te⁈zCF#mCއOG~%k"kKfqn)uu Fk&f'yOӦ|͇MiL8 PRQr4`KJĀdg0w*q lF b;1^e]*HUn紇&HO0.t%|+t2;u|j vܰ0LoKz9oHk!X3  RL0C^Z<[08L~HoT 7ZsΡ2AU=d2qqA y$qSb06Sv#pIM(t࿤m3HޣD JCZ(/<\uA!UfrLyR54VV;3l^_Lbt;Lgᰊ !2d0hGJsvmc`/t]P=f2d5Uuh0eML@=Lx0/j^88mcAY[љ0F!k\qA9\&7DKs1XYјAB㿒nΓXΌHIqlKM)TxLQ{;vBL̝q<p6X8-luH+'Va.&/OX5MSc.Pg6;ЭVFlј HeVX[kxkQHL#IQΪ`8Ohhy!]pK;" 7xD>Y̳d‚š ff$ǂ)uZ&M${7Jޠg&J' ^.LBrێ{8ihxm\0>9 aXMi(0ӔRx66.s\nDX#c;CU<& 9 AhuZ8#)%+zMf16$"/MMB.a$ /-wO,h1W9{#~c 5097"zD:#1xʹi ă:kf; aZs 7tk ҮwP!sܶ#+G UYN Mnf!|vsދ.z#=8"EVVGJXx蠷`4Bj;exZ6@ 'S'1?;$a蚄CKdk ފnmL!UXk7ڧ'ˆPimIDZׄ)mR$eRDڐ|ZbtqbL (pO'`lpb(rW%d`=jhճ[88wzq<)xVfvfv0~Œ?AGa@֪:$MDu L[J\h- F@"hQa=+f SNS :{"(N @iUƊ0ԁs)fa$R ςH27:KD7 .Mf3JlpH΄qdfJ4YXG3$07`0FكcȋQeI&Ds_ڱMV0pMSЛQ+? adVcc-4IJoPR+(*Y :oԈJiԒH'a)sZ 6>Jݴn 69HuhHMd&r) T-ɂx-wo$VRP(HLrR)S.grNR&0(^ξ9YS1;숔Z |BǺÍ -kG-. n#25Ms.#Qvx:HIchTAғtcZdM5!fKC* R)kfmQTYPi z}L7:CHi@@X ͻgY $8eܳG5Sb:BiO#F_΢fJL0b 02x*2*bu{.(2oEPIyW ,< y8f~s84nWu:wp^&*56;+0.ujeM2ztpsaź^}w,sd ZLz]TdZ,yi b,tPLΉ> OW5x; ^thrŹܘta,'za{RF2{#t{zU:*yNIhQ*vmqchУ:&O6JBV4grؤ\X+Q$Y*\Ew\^㫜d֛2R16Q$4;Ն+@P8m<կG{ cGqM{iHhtɎMl5*~S4"3S w*d)*ӨU 9-'Q 8A7uW0K72d :n( +M@T*e) H^mʲvoi=ڈУmi*ͣf)M܆RDbiR#Υ%k}LfM'zUX4\؝<JT#U0oE*CY8/p>*CٌpG2A٢c=3On#  &[ 1s=3 YJH0xEGV*`'F=Ԟ ^ZlA)UWU It5-˕ F 2u`lb"{L@o6*5R/fL2^cUʯ_V*b c] $A^;Blq >4YcD,n$L#JLPlĂκ7b:eftNR7%Vi[bFU>;DzKCVBW40M+Bx%ݣX*- yc[Ŗ8F% w"pE D"(J[ KɱNS[LnZ|~$aPMj2 vK*/}:@s"rL-Xg+8]3QB4*0H&&Paiy]#azRj 9҅ˆ1>͓SZ4 uֳ4ffHTGz᳞mC9*@HW=0&tQ pT )y/4jisiU*kȪl r*U0܄y@ ;XUT 95w$,k=ccE4QXܐP0a]M]5 QRr*/iօkK9@>U-pX!D c IFzJmFT]Rq#Ql'Ԛ<Ԛt1 q:Nv!J&Ymacw@k=o.|&6ՠ;O8.;JMJB6n3g?< LCcR󺬳1ATz!ӱnNsik:6_G40=88D^9;Z;,wf9`=jt{TO Qzvw*OWN2gDcf[Cz3Woun]"$eɅDnZV;t#ly&8q :RRz:Шַ(e $ЩhP)X`ea -&DiS qy4I[Ƃ<&TZ|7bI-88mfPO%n6"5Pa.EKYD&IL0UK2T a6Je`19mz8ps؃e ats }@B7'g &+ \/Dp1VWsrdƛ@d&l nN= @kHoe>ZlUPCr;A0c1r |emنp`7 d%b)qh ku$۩/K݇Ҟ\ӕăbPUeWU l.;H<5MumQԩ fh)U')e0`,r :>'EV66b Xd11I~&P x"{L O"X dxjbZ11)͐e7r2f2cVoR  ԑaMQ^I)X2jw*HVUQ6* =:X^fh22+oaTb+{GX0SqLT,E~c1.ԭT.$jXKAt%a]8~WA di!Xf`4h7eO~ϿO,Ze2χgW/fWyew@פŹ 0x"O *ꉙYx4X3D%+5oC ց .FԪ;A bIABhY8w$C-i>*w8Hp!L"cDxHOpCM G7QC'7< .2,Q[,gC+l Gqjrt:`\ 3p')9 bdNfm WZ\^VEІ3\AЧ(19O42@'53RNhp Tj՘XInޫ-~sZ aRZ&LŽg2bEAgN9kHa΄)ܝِ^_5)ë8xi5sN^Ti s/}RK|]6: N)ks8Q\,{ÙRc9 'KFj sLN(Kk_RRxR & Bw8 2~!:9i4ȋ N22$RTŠ $qHJ4$1Juhwf[|uyco%BLA+" 1'CXoLKKCIriGlI䈕P .xά'iIiia7BBJ!x&ܫNɚ )],މz?)ˋ}Vo]UVfc톝SBFŰtu@Z*Nۉid:zS ' $&<.NX3;,tiG݀ބT!:7$&"R*_WD~LH ˜M;+$b7Y. 2rP* U.?%w)MHI^@q@XFTuzܔK- kH2rw&iR"ĴVNQIQ-.2o^)ao;^-9+mLF p 6C. 3 qPZ3~ ߠ:.I}OT9h0L@ҫL6tf )u6ĀI'T8WauvɰLPxCnay04U.jprq^j`nK/A?OZFAX.iHڡV؟w:.Ợ=pU9 o}v;q}=wEv$? Yh {mG7X10NGM<{-i7$O.4@ReX]k-~..|–C[-4*lH2ޮiv*Zb*Z9M"R8ܘa3PNVѤ縝 EUf1<z=pE i{2o N\C!E+-2hNFkU00> b&(fԎOJs\I n1n'ie;КkL^H䞥JjuE=2nC)XخJÛIHNMHeZ\}3czt &O!`WIω (|^GxpSA w#l0 G &PL|jV3p92T~j_| | 2V sw彈彈Фi'[6 S#[uUc 'XiY[,VvHtgCbk$IȸX]QިsH®.7z>nP=͂l#S)wo#\<D'bA@RL+*T+*Fp$<]l6; ƅW":&lG½7 2͵)E2u<˛NJ7Yk12CMť6FiNIsA@'4Ü05+]q3qUgUN0kYW0cƈHJ͕:]5q@CYS0|6Qn8©4ugtٺ_5PlK$7;0Kd.Β61T^*xt04 WFN];5Ym$L AP[ri,$q%Xy{8e\6 ƫ+IN8&̘ 1 :`6.yכj4X^mvTcFTsEXwkj ZDMݴ% '{Z)}%F #D4@:Ί#Mܦ]qJnVwcZ%_.)@uLO%q(]'%̋D'1Ur{sI $NSTAlY, "8JN<.x%%tW3btX8gc0C5|4ai!j[d't v%X*Zbc!G VVBo{1G0oc4femY]K.äRi95R)pf<mQj fSH&WAe]1 g F|4;sXq`ZXq߹>;.t emx7nFPV+X|76,9<պ1pDP#/X%vn4;FV&shy{={#D"U$$nwM 9]# M$ 1$;qh`5sU/AS8Z\g yhf|0p gqⲽxD? [ (¡NwQEB\LufV+دi'`|(s:4P98&th+zI$Սs^`w{x18z^Xj5e7u_Y7DdW2m I\ 6XX9\DN*0$2)-atAӚ:&k69m';# hPNfݧ'4.: >+)4(ikllk#X+ ' ieu|BGR 2o=J0K%A$zhI)bV#6 *[rg "!׼גaXOl֐@EJ8s:Ht;Pw۪AFU^& :V J,ORԭ'LjC|{2=r#6ÉFÉ[pF{7ѣc'iŠ C\ʌlOjM`'>Z lOiASKsSv|i@ؓ;a4H2#x s}m f4怤d0l$V!$s jϑkN$S~&:J@2a>Ei.&&8 ěJ }aD;:z+:V&4Uc22 b8Z >KCft:ԇtkw* KZ%NVṡ[ԉ-ꎍjnvU:AoT4PBp4Fئr%*%Ѡ7OҤܟ!t!M&'Џx*@oZ@p-kdaB 0֖t;a\>@qcH!ùL$-(.cĩ`5(ߙK/skjg-f}ݪ!c5=HBtnwdB~3I"Hv !;}D4H䊛t+8,vR!I4ܥCFQrwB9’!J.=I .YJ. !@DncDvg)EB"^ĥlR@(5B!FaEIqq< 2 ꍀB!'B@tSr{OD`0ίT vH! 3C8}3o /Mt>l:RowAbPqsInRCl6`n65+[q"azKb[sw'E,kY *'n΍-WW<ȶ*[3#N!;AWa!s,KS;>Ar8Y[h@D98ϼ*ʻ  #a=yqwPW`JQ4q#DHdܡ+09Lek4$fԩ=i!wbc",PUxtGrG];‘If*fHTa #(DL*H~i*,dI ʩ-q) " {x 6Y&*O*k7ۭk_B]lZBr7E ef1077VЙd""p M@;2(5 b70uS_qm18"uU7f w+'=QTSHms;*M#p*;ANNKxF=ʙY8 뛖'yR藶tKN[NC\< DfH%T"oB%6LӦ\j:(}JM1x,\$hAZ>:,2VִU e{`&۝ HSixx$7Z*&H@|:9V*Ic < 1N೰ \`hZ/BzN#"=Ct$x VtL~|X.w]ԃLq ',iyE%t@d tH8xjCY6=0t0­11MztLL.@.I:=WAd`&x`5OuI 4idܯC X\| &A7S0a i.mHo1A`묑n s)'Z%=$]&\<5 s6)1LY0InU889`LHi U0L|F$ 9 p ޗ? 4MLjlܥ4fsl %gEhhpv.P6Xv ||I/pj?xhv#IJA͒s8&&9wj.XŬ{dZjd8ǽLET<;'AeN! 4@it@Val<20Û..%y} M,Nұa-SZ)*PUlIDme? JS ;g1QZZ @iN75)z; K_"ctE1oJa ; zN1}'(țsp/Ao1e\ۂӽXi&;FlaNT- XğxLIt7}T۝/HW`Q08o*tA;'IR\kNPDiCN D*1]%bcb/ ]1~!Df@anq6Jq lrn7q.PFTĬkAJ&_5teXI:)ʵE:fOZ?3~Q7]J}%cC{ б:gHfe$^w~` ,1[ܜwB=L 6Lر$?s|#}ΥSyau (&"D[X`,/D: :viZYy2ӪsT:rw} P#]c5 G6L9^^\! {r1Z`F%QYR\`C]SⱾ{Lp>MwA\Rmqi-*]*L 8pCb-=Es'N!#_MvK};mǁSH `!HG%,0*q!`ano10H^S0!) \P6e@cd({P6bǍi/xyhQ59BB*P!8B2lim'B*=aR}Od܅=HBQk* Mg1U&j66&Gx-Vpd䛩 =Gs Ujļ=Lȋ劓D/ak2W\Y8wHd'yf/BcNrdS&'Gk+C[?f4'fQQU(4Đc)6Kv1g>0Ru*fܨ̀;abI-W}8! mbKX7@:Ic:WK =~ _R~1K HAFVҵoC̦/ϡ<alQFV{ۻJ|=  (1'l->t}Hsa= qAeEyČR?C> =}t|<7%5|[P\BN^|mri=leÌPϕ>h@"" V86Ck$/y8'RS1l8 6^+!v_3~ )NE+QzJ 2ޏAyJ >,&aXY Z PA!BA!J, Jbe6\:2wp1 .i'RЮo~YN{1_ef+FFSSڰ> x%lf1 *9427Gb3;yZ?_C~g+b+ k\ *yU>:할 Qet kU9WAއatvaCڏ1&ez?B'ΐ=ԂRr@(mw }P!Aȍ3 (7;ZaD[r@GiF8*lCjY6@#3*e&51@Le46Up+B-ǂkh7*ΏiP66 OXHW X!"5S.sXY"@=Pƛ{%SgLk4<0Gls∻%R\PT! YY_)QDϤqLbC,1N0Ԡ[}Q"B M>K5EY̬jT9[vTC&gݮI5% @'MB&)sSL 8\w&Jֆ0*KXQ"Eon&G9[R *Qu eWE5ghxŽiu 24ejo*Rm12dЗ`Q 7lA;L3ةXSiuJt<f4!BmE SIܔς M69j s4 #T' 2B4 u\@mAvH{LE* ا`'YWa8fSR`"`**5z"2*Sg,yM:IL UB'11<,tz雡E>+-PrT9,v7A.IP}p2L@wk/M3 PYt>p|!2Fnkt:v 41N$(( ¡1xy0X  azrR`9[4vWX@vH䅸#z€UU s4 2nRfEf[E]ǹX"S5]wlN5TccàZ,=uvg8i568/NwK-NS1*5o HM Y Fv4opv<;m-ߡq%iCo; 3,,1 Z !BΠ +B !B}A}>X^A!4&IRեRWѪ2ǷH#1/wJS9q]#e:;d&=0ISL??JPf%i;'B)C /f׿+`bl+ֳ0q0̳sM WF'ѺG{\*.+|o+߈OwAX?N $„P T.B '߶OL~>&/w%DB}Ok~L~߲~+d!荖ئU(JBvB=P\9RCG4H Y^Gj4@iZEdEFQ %i$!l*f!YxX,L|LA5BRԝ5Rm+[ZBc5Yx0FꢔzF,BRD%JE9MdXΪAHL+Y[e8plVx(b(bɾ8^(S Pu)"4:<|X'w9#sF\+ f0u=8:[7MV-,34ui%@W3n49XS)פ:9ÇB[1C L\7a;+*Iln~M̀A0PxJ:_+8 ΢Zy7 SDIOh*3 dg8GD&HL Bpkp,[ۤ4{Ф!B27w1r.'tBBOf5 7}hPdQL!R10j lւA*h:Xu W5Ig*Όm\{՘L8X+tv(YޅzJgFFWc`btFaa45Ͽ?EúN(}p N&.2y,"HIq$ԕ+B:+:.Uڹڸ+= PABA!BA!A\`s0Z-u9)%::K{ tQ[Gf*}Nj"t !hzoWW#c⹸D P"o GFvx؛Wt|<QF*.R$8i (UgJn[N^LePEzDW m1F+7PW bJs$51E )P! C<}0_,>ث`7ҽ8ʳ:+{T3roAyܽ/ߣ%[^b=$pRm$,usIȒ8. `]'Iǝ-oة k[,Vऺ$<7aR=$3(2MQQ:N\08@4OfZ = \r 'i+L qk\$:UvFv2J+.+~4q" rCLHtMԨk$K٪n TfؤU qP!)-7ɡ.$'j8in(Q12! ;ymb*k&Xe^ =L6H)ې!GԪ::&ب>DkkIx(5i T!NŽ7z*KMb)=oPվh֖3x 2lS_P=`Jr,D\%D jjI|ePԆҕH\-Ki ܈ 1ԤNcEX7R`%Y,bO @+ Ex mGyCJu`|OGN W EZ5NjrČۥ I%(pP5R0ШDXU^%ŧ1kҴ}cR~ tۖzOپ ,S+ߖgX?6t1?dC&PfgKA[} }7a⿠}q^+6oB )P!'~>2md!\ǿi_CP\u{B} oC?QrdVF Fa-a*B!@:JB[uǍRЦuUGĈDEX rN 37t!((Y $)È*tٴ)1I "Y!,<{_|6D!L4[b@ei!dP{ %Vw5ެn)iPpNQ$)% 9u e cE`h>iD@"!DAR BWYGC4KiԎ$d|D-k7K%}묇n# ;֕00BmlCHLVߔ鮾++蠜GU݋[o\*٧v)EuzO rZ{dᾺ~{ϸLۻ԰wƲ{ MNMp}2XxJcD{ z/Eqn#`KzInYыMl'ӽi..hP؍UR6 UkPŰ<X f߂@{e@QB@7DeeE ;h!G%4\,vC0et<*!F]̒^Z` &7䉔R %MI/ET0$&@ n@hS=呰/ *񱛂h0j}~oܧL#8zCƛ,w^zGmԏT}@Aֆ Ag;_{׸ctLb7i :{T&ALBA!BA!AB!>ýF;BUͦ\AB.%?oF}wA}##> {}5E!izo=bq.RK4B}+9=# q +ZvHB Bu3bDM}W,,.%I{$ R TzMI_` 3 oNJ&xKs`77h9 !7R$nR֖D˅no :G"xrDZRc3 ]a USF2ji;)8fɚJ24[5ܵ=."kzktՎ BuG%[ xeC0]8qU9+5T+qbiTPu:y]!4)ς[yХՀRa!U !Qև71G3 0@lR:~U!~HP!EȨ.5FNQ jA.L40! Ž8poM=1"@| pK3 *|[qOwra\<UBqX:4=I&<4v5 xMFö&\mdGn.7B5\`ßx[JY#djTXHpЄ!2r߇n< ku';IJLIX2dB}A tax "y}+܇|VL  T)PABA!BA!@Π +B !B ! B'p>)gL_HJ s~9e Eˤ\W >Ƿ)0,[tXAoךD֋)XE nPTէzUȟyFdE(h PMS5#I % +I$J@G$EJfЫJ+t[jkǀ+lH #rNȲXYvpVIca]d7u%(ddmGk4Rq kRޒZEJT$M,q̐hOGU10~6CVK}txlw׬+a5?g(:)Im~x:qSsmIV \cnhKu>b cUI\ng;6rI%AN GonNBsddNLۢz;PUҲS&1VM2m\"@!J\~J6Xzԟ*4,'+jUA*6+i&'%Qbt޵dB>  +$P$5]\]JPMt4`ob$ΩLBT!JwMfJmo&5A „& NLH6ItE& M}$4nN4ȝSO%%EiUQ\!Zqxi3UQ$MN8YxL o}7ظ0n=~}෣aqiWah4Xk} I bB !B ! B !B !P )B !B{OOgyeҽ8da= :-H/,{H5zAL` \O^/J0n4Csܱ故s l&ſYQ@@!lRۡBū%C^LMU/F ܔ=:,[t6V,8 5jN+\y+;n'%ŹVveE((2Vk ]ҩsV&̺VCL o$iqXK0 lIArfam h@ ЄA!PA!JA!BA!B endstream endobj 925 0 obj <>stream endstream endobj 924 0 obj <>stream endstream endobj 920 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.186 Tw 10 0 0 10 70.8661 724.8299 Tm (\021\024\004\022\024\r\t\036 \n\031\021\026\006\017\017 \017\035\017 \027\ \036\002\024\035\034\001\017\036 \007\036\035\036\006\017\017/\r\f\021\026\ \r\022\017 )Tj 0.094 Tw 0 -1.218 TD (\r)Tj /Span<>> BDC ( )Tj EMC (\022\024\007\017\030\031\033\013\017\b \024\002\035\026\f\021\016\b, \026\ )Tj /Span<>> BDC ( )Tj EMC (\023\030\017\n\036\030\027\024 15% \r\026\030\017\026\027\021\024\r )Tj 0.613 Tw T* (\016\r\035\016\033\021\f\016 \023\030\024\021\016\032\036\027\027\t\n\017\ \023\036\030\036\f\021\030\024\005\022\026\n\017 [14,15])Tj /T1_1 1 Tf 0 Tw (. )Tj /T1_0 1 Tf -0.029 Tw T* (\215\030\017\002\035\017\017\021\036\035\034\027\024 20\22650% \f\035\031\ \004\026\036\r \f\017\027\007\030\024\n\026 \033\r\036\027\017\035\034)Tj 0 Tw (-)Tj 0.084 Tw T* (\027\024\020\024 \023\024\035\017\023\024\026 \027\036 \017\n\036\033\021\ \f\036\n\036\005\027\024\020\024 \026\027\026\n\027\036\026 \017)Tj /Span<>> BDC ( )Tj EMC (\024\002\031)Tj 0 Tw (-)Tj T* (\f\035\024\r\035\036\027\t \n\031\021\026\006\017\016\n\017 )Tj /T1_1 1 Tf [(de nov)13.1(o )]TJ /T1_0 1 Tf ([14\22616,25].)Tj 0.305 Tw 0 -1.218 TD (\221\024\020\035\026\f\027\024 \017\027\235\024\030\n\026\006\017\017 \024\ \007\027\024\005 \017)Tj /Span<>> BDC ( )Tj EMC (\027\026\017\002\024\035\036\036 \023\024\035\027\t\b )Tj 0.319 Tw 0 -1.218 TD (\002\026 \007\026\027\027\t\b \024)Tj /Span<>> BDC ( )Tj EMC (\n\031\021\026\006\017\016\b \r)Tj /Span<>> BDC ( )Tj EMC (\020\036\027\024\n\036 \004\036\035\024\r\036\022\026 HGMD )Tj -0.053 Tw T* [(P)35(r)-32(ofessional, \r)]TJ /Span<>> BDC ( )Tj EMC (\n\017\030\036 \024\023\017\f\026\027\024 \r\f\036\020\024 166 \023\026\021\ \024\020\036\027\027\t\b \r\026)Tj 0 Tw (-)Tj -0.034 Tw T* (\030\017\026\027\021\024\r \r)Tj /Span<>> BDC ( )Tj EMC (\020\036\027\036 )Tj /T1_1 1 Tf 0 Tw (SMAD4)Tj /T1_0 1 Tf -0.034 Tw ( \017)Tj /Span<>> BDC ( )Tj EMC (168)Tj /Span<>> BDC ( )Tj EMC (\227 \r)Tj /Span<>> BDC ( )Tj EMC (\020\036\027\036 )Tj /T1_1 1 Tf 0 Tw [(BMP)66(R1A. )]TJ /T1_0 1 Tf 19.11 0 Td (\200\023\024\035\027\036 )Tj 0.115 Tw -19.11 -1.218 Td (\r\036\030\024\016\021\027\024, \004\021\024 \036\f\021\034 \023\026\021\ \024\020\036\027\027\t\036 \r\026\030\017\026\027\021\t \020\036\027\024\ \r, \f\r\016)Tj 0 Tw (-)Tj T* (\026\027\027\t\b \f)Tj /Span<>> BDC ( )Tj EMC (C\236\215, \022\024\021\024\030\t\036 \036\013\036 \027\036 \017\007\036\ \027\021\017\235\017\006\017\030\024\r\026\027\t.)Tj /T1_2 1 Tf 0 -2.436 TD (\021\f\t\b\t\201\r\217\220\004\235 \220\004\006\003\t\b\004)Tj /T1_0 1 Tf 0.126 Tw 0 -1.218 TD (\215\036\030\r\t\036 \022\035\017\027\017\004\036\f\022\017\036 \023\030\ \024\016\r\035\036\027\017\016 \026\002\024\035\036\r\026\027\017\016 \004\ \026\013\036 )Tj 0.113 Tw T* (\r\f\021\030\036\004\026\036\021\f\016 \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \n\031\032\f\022\024\020\024 \023\024\ \035\026 \(61%\), \r\024)Tj 0 Tw (-)Tj 0.195 Tw T* [(\027\017\022\026\033\021 )0.6(\007\024)]TJ /Span<>> BDC ( )Tj EMC 4.858 0 Td [(20-\035\036\021\027\036\020\024 )0.6(\r\024\030\026\f\021\026 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 9.968 0 Td [(\r\022\035\033\004\026\033\021 )0.6(\r)]TJ /Span<>> BDC ( )Tj EMC 5.402 0 Td (\f\036\002\016 )Tj -0.012 Tw -20.228 -1.218 Td [(\002\024\035\034 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC [(\032\017\r\024\021\036, )0.5(\007\017\026\030\036\033, )0.5(\r\t\007\036\035\036\027\017\036 )0.5(\022\030\024\r\017, )0.5(\026)]TJ /Span<>> BDC ( )Tj EMC [(\021\026\022\032\036 )0.5(\r\t)]TJ 0 Tw (-)Tj 0.034 Tw T* (\023\026\007\036\027\017\036 \023\024\035\017\023\024\r \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\017\b \035\024\022\026\035\017\026\006\017\017 \r)Tj /Span<>> BDC ( )Tj EMC (\023\030\016\n\024\005 \022\017\001)Tj 0 Tw (-)Tj T* (\022\036 [3,8,44].)Tj 0.153 Tw T* (\203\026 \024\f\027\024\r\026\027\017\017 \r\t\030\026\032\036\027\027\024\ \f\021\017 \022\035\017\027\017\004\036\f\022\017\b \023\030\024\016\r\035\ \036)Tj 0 Tw (-)Tj 0.111 Tw T* (\027\017\005 \017)Tj /Span<>> BDC ( )Tj EMC (\r\024\030\026\f\021\026 \017\b \r\024\027\017\022\027\024\r\036\027\017\ \016 \r)Tj /Span<>> BDC ( )Tj EMC (1975 \020\024\007\031 \002\t\035\026 )Tj 0.333 Tw T* (\r\t\007\036\035\036\027\026 \f\035\036\007\031\033\013\026\016 \022\035\ \026\f\f\017\235\017\022\026\006\017\016 \033\r\036\027\017\035\034\027\024\ \020\024 )Tj 0 Tw T* (\023\024\035\017\023\024\026 [30]:)Tj 0.015 Tw T* (\243)Tj /Span<>> BDC [( )-252( )]TJ EMC 1 0 Td (\007\036\021\f\022\017\005 \033\r\036\027\017\035\034\027\t\005 \023\024\ \035\017\023\024, \022\024\021\024\030\t\005 \b\026\030\026\022\021\036\ \030\017)Tj 0 Tw (-)Tj 0.174 Tw T* (\031\036\021\f\016 \002\024\035\036\036 \030\026\027\027\017\n \r\024\027\ \017\022\027\024\r\036\027\017\036\n \f\017\n\023\021\024\n\024\r )Tj 0 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\036\036 \021\016\032\036\035\t\n \021\036\004\036\027\017\036\ \n \026\002\024\035\036\r\026\027\017\016;)Tj 0.172 Tw -1 -1.218 Td (\243)Tj /Span<>> BDC [( )-95( )]TJ EMC 1 0 Td [(\033\r\036\027\017\035\034\027\t\005 )0.6(\023\024\035\017\023\024 )0.5(\021\024\035\f\021\024\005 )0.6(\022\017\001\022\017 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 16.985 0 Td (\020\036\027\036\030\026\035\017)Tj 0 Tw (-)Tj 0.157 Tw -16.985 -1.218 Td (\024\r\026\027\027\t\005 \033\r\036\027\017\035\034\027\t\005 \023\024\035\ \017\023\024)Tj /Span<>> BDC ( )Tj EMC (\227 \r\026\030\017\026\002\036\035\034\027\t\036 )Tj 0.252 Tw T* (\235\024\030\n\t \024\007\027\024\020\024 \026\002\024\035\036\r\026\027\ \017\016, \022\024\021\024\030\t\036 \b\026\030\026\022\021\036\030\017)Tj 0 Tw (-)Tj 0.174 Tw T* (\031\033\021\f\016 \002\024\035\036\036 \023\024\007\027\017\n \027\026\ \004\026\035\024\n \017)Tj /Span<>> BDC ( )Tj EMC (\030\026\027\024\024\002\030\026\027\024\005 )Tj 0 Tw T* (\022\035\017\027\017\004\036\f\022\024\005 \f\017\n\023\021\024\n\026\021\ \017\022\024\005.)Tj -0.035 Tw -1 -1.218 Td (\212\036\021\f\022\017\005 \033\r\036\027\017\035\034\027\t\005 \023\024\ \035\017\023\024)Tj /Span<>> BDC ( )Tj EMC (\227 \220\021\024 \235\024\030\n\026, \r\024\027\017\022\026)Tj 0 Tw (-)Tj 0.066 Tw T* (\033\013\026\016 \031)Tj /Span<>> BDC ( )Tj EMC (\007\036\021\036\005 \030\026\027\027\036\020\024 \r\024\030\026\f\021\026\ \(\023\036\030\r\t\036 \023\030\024\016\r\035\036\027\017\016 )Tj -0.043 Tw T* [(\r\024\n\024\032\027\t )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC [(\r\024\030\026\f\021\036 )0.5(\007\024)]TJ /Span<>> BDC ( )Tj EMC 10.134 0 Td [(1 \020\024\007\026\), )0.5(\007\035\016 )0.5(\022\024\021\024\030\024\005 \b\026\030\026\022\021\036)]TJ 0 Tw (-)Tj 0.025 Tw -10.134 -1.218 Td [(\030\036\027 \030\024\f\021 )0.5(\023\024\035\017\023\024\r )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC [(\032\036\035\031\007\022\036, )0.5(\021\024\027\022\024\005 )0.5(\022\017\001\022\036 \017)]TJ /Span<>> BDC ( )Tj EMC 18.92 0 Td (\021\024\035\f\021\024\005 )Tj 0.047 Tw -18.92 -1.218 Td [(\022\017\001\022\036. )0.5(\215\026\006\017\036\027\021\t )0.6(\f\021\030\026\007\026\033\021 )0.5(\024\021 )0.5(\007\017\026\030\036\017, )0.6(\022\030\024\r\024\021\036\004\036\027\017\005, )]TJ 0 Tw T* (\017\027\r\026\020\017\027\026\006\017\017.)Tj 0.222 Tw T* (\215\024 \007\026\027\027\t\n \035\017\021\036\030\026\021\031\030\t, \031\ )Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \n\035\026\007\001\036\005 \r\024)Tj 0 Tw (-)Tj 0.094 Tw T* (\030\026\f\021\027\024\005 \020\030\031\023\023\t \(\024\021 5 \007\024)Tj /Span<>> BDC ( )Tj EMC (14 \035\036\021\) \f\022\024\023\035\036\027\017\016 \023\024\035\017\023\ \024\r )Tj 0.107 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (8% \f\035\031\004\026\036\r \023\030\017\r\024\007\016\021 \022)Tj /Span<>> BDC ( )Tj EMC (\023\024\r\t\001\036\027\027\024\005 \023\024\021\036\030\036 \f\t\r\024\ )Tj 0 Tw (-)Tj 0.187 Tw T* (\030\024\021\024\004\027\t\b \002\036\035\022\024\r \004\036\030\036 \032\ \036\035\031\007\024\004\027\024-\022\017\001\036\004\027\t\005 \021\030\ \026\022\021 )Tj 0.312 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\030\026\r\017\021\017\036\n \r\t\030\026\032\036\027\027\024\005 \020\017\ \023\024\023\030\024\021\036\017\027\036\n\017\017 \(\020\017\023\024)Tj 0 Tw (-)Tj 0.176 Tw T* (\026\035\034\002\031\n\017\027\036\n\017\016, \020\017\023\024\020\026\n\ \n\026\020\035\024\002\031\035\017\027\036\n\017\016\) \017)Tj /Span<>> BDC ( )Tj EMC (\024\021\036\004\027\024\020\024 )Tj 0 Tw T* (\f\017\027\007\030\024\n\026 [26,29,30].)Tj 0.215 Tw T* (\215\030\017 \021\016\032\036\035\024\n \021\036\004\036\027\017\017 \007\ \036\021\f\022\024\020\024 \033\r\036\027\017\035\034\027\024\020\024 \023\ \024\035\017)Tj 0 Tw (-)Tj 0.238 Tw T* (\023\024\026 \f\n\036\030\021\034 \024\002\t\004\027\024 \027\026\f\021\ \031\023\026\036\021 \r)Tj /Span<>> BDC ( )Tj EMC (\030\026\027\027\036\n \r\024\030\026\f\021\036. )Tj 0.123 Tw T* (\025\030\024\n\036 \021\024\020\024, \n\027\024\020\017\036 \017)Tj /Span<>> BDC ( )Tj EMC [(\220\021\017\b \023\026\006\017\036\027\021\024\r )0.5(\017\n\036\033\021 \r\030\024\032)]TJ 0 Tw (-)Tj -0.005 Tw T* (\007\036\027\027\t\036 \026\027\024\n\026\035\017\017, \r)Tj /Span<>> BDC ( )Tj EMC (\021\024\n \004\017\f\035\036 \n\026\022\030\024\006\036\235\026\035\017\ \033 \017)Tj /Span<>> BDC ( )Tj EMC (\020\036\027\036)Tj 0 Tw (-)Tj T* (\030\026\035\017\024\r\026\027\027\031\033 \020\017\023\024\021\024\027\ \017\033 [27].)Tj 0.124 Tw T* (\200 \026\r\017\f\017\n\024\f\021\017 \024\021 \024\002\255\036\n\026 \023\ \024\030\026\032\036\027\017\016 \024\030\020\026\027\024\r \032\036\035\ \031)Tj 0 Tw (-)Tj -0.038 Tw T* (\007\024\004\027\024-\022\017\001\036\004\027\024\020\024 \021\030\026\022\ \021\026 \024\021\007\036\035\034\027\024 \002\t\035\017 \r\t\007\036\035\ \036\027\t \020\036)Tj 0 Tw (-)Tj -0.032 Tw T* (\027\036\030\026\035\017\024\r\026\027\027\t\005 \033\r\036\027\017\035\ \034\027\t\005 \023\024\035\017\023\024 \017)Tj /Span<>> BDC ( )Tj EMC (\033\r\036\027\017\035\034\027\t\005 )Tj 0.163 Tw T* (\023\024\035\017\023\024 \021\024\035\f\021\024\005 \022\017\001\022\017\ [28]. \203\026)Tj /Span<>> BDC ( )Tj EMC (\f\036\020\024\007\027\016\001\027\017\005 \007\036\027\034 )Tj 0.065 Tw 23.244 64.543 Td (\023\030\017\027\016\021 \024\002\255\036\007\017\027\016\033\013\017\005\ \021\036\030\n\017\027)Tj /Span<>> BDC ( )Tj EMC (\227 \f\017\027\007\030\024\n \033\r\036\027\017\035\034)Tj 0 Tw (-)Tj 0.291 Tw T* [(\027\024\020\024 )0.5(\023\024\035\017\023\024\026. )0.6(\025\026\022 )0.5(\023\030\026\r\017\035\024, )0.6(\023\036\030\r\t\036 )0.5(\022\035\017\027\017\004\036\f\022\017\036 )]TJ -0.023 Tw T* (\023\030\024\016\r\035\036\027\017\016 \r\024\027\017\022\026\033\021 \r\ )Tj /Span<>> BDC ( )Tj EMC (\r\024\030\026\f\021\036 \007\024)Tj /Span<>> BDC ( )Tj EMC (20 \035\036\021 \017)Tj /Span<>> BDC ( )Tj EMC (\026\r\017\f\016\021 )Tj 0 Tw T* (\024\021 \023\026\021\024\020\036\027\027\024\020\024 \r\026\030\017\026\ \027\021\026 \027\026\f\035\036\007\031\036\n\024\020\024 \020\036\027\026\ [29,30].)Tj /T1_2 1 Tf 0.14 Tw 0 -2.436 TD [(\021\f\t\b\t\201\r\217\220\t\r )0.6(\212\006\002\235\f\r\b\t\235 )0.5(\210)]TJ /Span<>> BDC ( )Tj EMC 12.586 0 Td [(\212\004\204\t\r\b\003\002 )0.6(\217)]TJ /Span<>> BDC ( )Tj EMC 5.771 0 Td (\212\004\003\002\n\r\b)Tj 0 Tw (-)Tj -18.357 -1.218 Td (\b\013\214 \004\006\t\004\b\003\002\214 \n\r\b\004 )Tj /T1_3 1 Tf (SMAD4)Tj /T1_0 1 Tf 0.191 Tw 0 -1.218 TD (\215\026\021\024\020\036\027\027\t\036 \r\026\030\017\026\027\021\t \020\ \036\027\026 )Tj /T1_1 1 Tf 0 Tw (SMAD4)Tj /T1_0 1 Tf 0.191 Tw ( \f\r\016\026\027\t \f)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\036\036 )Tj 0.268 Tw T* (\004\026\f\021\t\n, \004\036\n \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\023\026\021\024\020\036\027\027\t\n \r\026\030\017\026\027\021\024\n )Tj /T1_1 1 Tf 0 Tw T* [(BMP)66(R1A, )]TJ /T1_0 1 Tf 0.275 Tw 3.905 0 Td (\023\024\030\026\032\036\027\017\036\n \r\036\030\b\027\017\b \024\021\007\ \036\035\024\r \032\036\035\031\007\024\004\027\024-)Tj 0.24 Tw -3.905 -1.218 Td [(\022\017\001\036\004\027\024\020\024 )0.5(\021\030\026\022\021\026 \(\r )0.5(70% \f\035\031\004\026\036\r\) )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC (\023\024\r\t\001\036\027\027\t\n )Tj 0.141 Tw T* (\030\017\f\022\024\n \030\026\r\017\021\017\016 \030\026\022\026 \032\036\ \035\031\007\022\026 \(\007\024 20%\) [6,31\22635])Tj /T1_1 1 Tf 0 Tw (. )Tj /T1_0 1 Tf 0.297 Tw 0 -1.218 TD (\200)Tj /Span<>> BDC ( )Tj EMC (30% \f\035\031\004\026\036\r \r\024\n\024\032\027\024 \f\024\004\036\021\ \026\027\017\036 \f)Tj /Span<>> BDC ( )Tj EMC (\f\017\027\007\030\024\n\024\n )Tj 0.267 Tw 0 -1.218 TD (\027\026\f\035\036\007\f\021\r\036\027\027\t\b \020\036\n\024\030\030\026\ \020\017\004\036\f\022\017\b \021\036\035\036\026\027\020\017\024\220\022\ \021\026\017\005 )Tj 0.038 Tw 0 -1.218 TD [(\(\203\206\230, \f\017\027\007\030\024\n \217\036\027\007\033-\210\f\035\ \036\030\026-\200\036\002\036\030\026\) )0.5([7,31]. \215\036\030\r\t\036 )]TJ 0.063 Tw T* (\023\030\024\016\r\035\036\027\017\016 \r)Tj /Span<>> BDC ( )Tj EMC (\r\017\007\036 \027\024\f\024\r\t\b \022\030\024\r\024\021\036\004\036\027\ \017\005 \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027)Tj 0 Tw (-)Tj 0.065 Tw T* (\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\203\206\230 \r)Tj /Span<>> BDC ( )Tj EMC (50\22695% \f\035\031\004\026\036\r \r\024\027\017\022\026\033\021 \007\024\ )Tj /Span<>> BDC ( )Tj EMC (20-\035\036\021\027\036)Tj 0 Tw (-)Tj 0.141 Tw T* (\020\024 \r\024\030\026\f\021\026. \221\017\027\007\030\024\n \027\026\f\ \035\036\007\f\021\r\036\027\027\t\b \020\036\n\024\030\030\026\020\017\004\ \036)Tj 0 Tw (-)Tj 0.354 Tw T* (\f\022\017\b \021\036\035\036\026\027\020\017\024\220\022\021\026\017\005\ \r\t\f\021\026\r\035\016\036\021\f\016 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\027\026\035\017\004\017\017 )Tj 0.14 Tw T* (\021\030\036\b \017)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\036\036 \017)Tj /Span<>> BDC ( )Tj EMC (\f\035\036\007\031\033\013\017\b \022\035\017\027\017\004\036\f\022\017\b\ \022\030\017\021\036\030\017\036\r )Tj 0.61 Tw T* (\025\033\030\026\f\026\024: \f\023\024\027\021\026\027\027\t\036 \030\036\ \006\017\007\017\r\017\030\031\033\013\017\036 \027\024\f\024\r\t\036 )Tj 0.903 Tw T* (\022\030\024\r\024\021\036\004\036\027\017\016, \n\027\024\032\036\f\021\ \r\036\027\027\t\036 \021\036\035\036\026\027\020\017\024\220\022\021\026\ \017\017 )Tj 0.369 Tw T* (\022\024\032\017 \017)Tj /Span<>> BDC ( )Tj EMC (\f\035\017\017\f\021\t\b \024\002\024\035\024\004\036\022, \027\026\035\ \017\004\017\036 \f\024\f\031\007\017\f\021\t\b )Tj -0.01 Tw T* [(\n\026\035\034\235\024\030\n\026\006\017\005 )0.6(\r)]TJ /Span<>> BDC ( )Tj EMC 7.114 0 Td [(\030\026\035\017\004\027\t\b )0.6(\024\030\020\026\027\026\b, )0.5(\f\036\n\036\005\027\t\005 )0.6(\026\027\026\n)]TJ 0 Tw (-)Tj -7.114 -1.218 Td (\027\036 \026\002\024\035\036\r\026\027\017\016 [36].)Tj 0.046 Tw T* [(\200 \030\026\002\024\021\036 L)-32(in A.E. \017)]TJ /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. \024\021\n\036\004\026\036\021\f\016, \004\021\024 \027\ \036\022\024\021\024\030\t\036 )Tj 0.176 Tw T* (\023\026\021\024\020\036\027\027\t\036 \r\026\030\017\026\027\021\t \020\ \036\027\026 )Tj /T1_1 1 Tf 0 Tw (SMAD4 )Tj /T1_0 1 Tf 0.176 Tw 14.85 0 Td (\023\030\017\r\024\007\016\021 \022)Tj /Span<>> BDC ( )Tj EMC (\026\031\021\024)Tj 0 Tw (-)Tj 0.153 Tw -14.85 -1.218 Td (\f\024\n\027\024-\007\024\n\017\027\026\027\021\027\024\n\031 \f\017\027\ \007\030\024\n\031 \204\026\005\030\026)Tj /Span<>> BDC ( )Tj EMC (\227 \026\002\024\035\036\r\026)Tj 0 Tw (-)Tj 0.016 Tw T* (\027\017\033 \f\024\036\007\017\027\017\021\036\035\034\027\024\005 \021\ \022\026\027\017 \f)Tj /Span<>> BDC ( )Tj EMC (\n\031\035\034\021\017\f\017\f\021\036\n\027\t\n \023\024\030\026)Tj 0 Tw (-)Tj T* (\032\036\027\017\036\n \017)Tj /Span<>> BDC ( )Tj EMC (\031\n\f\021\r\036\027\027\024\005 \024\021\f\021\026\035\024\f\021\034\033\ [37].)Tj /T1_2 1 Tf 0.14 Tw 0 -2.436 TD [(\021\f\t\b\t\201\r\217\220\t\r )0.6(\212\006\002\235\f\r\b\t\235 )0.5(\210)]TJ /Span<>> BDC ( )Tj EMC 12.586 0 Td [(\212\004\204\t\r\b\003\002 )0.6(\217)]TJ /Span<>> BDC ( )Tj EMC 5.771 0 Td (\212\004\003\002\n\r\b)Tj 0 Tw (-)Tj -18.357 -1.218 Td (\b\013\214 \004\006\t\004\b\003\002\214 \n\r\b\004 )Tj /T1_3 1 Tf (BMPR1A)Tj /T1_0 1 Tf 0.046 Tw 0 -1.218 TD (\211 \027\024\f\017\021\036\035\036\005 \023\026\021\024\020\036\027\027\ \024\020\024 \r\026\030\017\026\027\021\026 \020\036\027\026 )Tj /T1_1 1 Tf 0 Tw [(BMP)66(R1A )]TJ /T1_0 1 Tf 20.294 0 Td (\030\036\007)Tj (-)Tj 0.356 Tw -20.294 -1.218 Td (\022\024 \r\f\021\030\036\004\026\036\021\f\016 \023\024\030\026\032\036\ \027\017\036 \r\036\030\b\027\017\b \024\021\007\036\035\024\r \240\025\230\ , )Tj 0.024 Tw T* (\026)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\016\r\035\036\027\017\016 \026\002\024\035\036\r\026\027\017\ \016 \r)Tj /Span<>> BDC ( )Tj EMC (\021\024\035\f\021\024\005 \022\017\001\022\036 \r\026\030\034\017\030\031\ )Tj 0 Tw (-)Tj 0.07 Tw T* (\033\021 \024\021 \027\026\035\017\004\017\016 \f\n\036\001\026\027\027\024\ \020\024 \023\024\035\017\023\024\026 \(\r \022\017\001\022\036 \024\023\ \030\036)Tj 0 Tw (-)Tj 0.095 Tw T* (\007\036\035\016\033\021\f\016 \022\026\022 \033\r\036\027\017\035\034\027\ \t\036, \021\026\022 \017)Tj /Span<>> BDC ( )Tj EMC (\026\007\036\027\024\n\026\021\024\027\t\036 \023\024)Tj 0 Tw (-)Tj 0.124 Tw T* (\035\017\023\t\) \007\024)Tj /Span<>> BDC ( )Tj EMC (\r\t\016\r\035\036\027\017\016 \022\024\035\024\030\036\022\021\026\035\034\ \027\024\020\024 \030\026\022\026 \027\026)Tj /Span<>> BDC ( )Tj EMC (\235\024\027\036 )Tj 0.007 Tw T* [(\024\021\f\031\021\f\021\r\017\016 )0.5(\023\024\035\017\023\024\r )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC [(\021\024\035\f\021\024\005 )0.5(\022\017\001\022\036 [38]. )0.5(\203\036\022\024\021\024\030\t\036 )]TJ 0.136 Tw T* (\026\r\021\024\030\t \007\026\032\036 \r\t\007\036\035\016\033\021 \024\021\ \007\036\035\034\027\t\005 \r\017\007 \023\024\035\017\023\024\027\024\020\ \024 )Tj 0.22 Tw T* (\f\017\027\007\030\024\n\026)Tj /Span<>> BDC ( )Tj EMC (\227 \027\026\f\035\036\007\f\021\r\036\027\027\t\005 \f\n\036\001\026\027\ \027\t\005 \023\024\035\017\023\024)Tj 0 Tw (-)Tj -0.005 Tw T* [(\027\t\005 \f\017\027\007\030\024\n )0.5(\(her)-24(edi)-24(t)15.1(ar)-24(y mix)12(ed pol)35(yposis )0.5(syndr)-32(ome)]TJ /Span<>> BDC ( )Tj EMC (\227 )Tj 0.096 Tw T* (HMPS\), \024\021\n\036\004\026\016 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\n \036\020\024 \024\002\031\f\035\024\r\035\036\027\027\024\ \f\021\034 \023\026\021\024)Tj 0 Tw (-)Tj T* (\020\036\027\027\t\n\017 \r\026\030\017\026\027\021\026\n\017 \020\036\027\ \026 )Tj /T1_1 1 Tf [(BMP)66(R1A )]TJ /T1_0 1 Tf ([39,40].)Tj 0.125 Tw T* (\203\026 \024\f\027\024\r\026\027\017\017 \026\027\026\035\017\026 \007\ \026\027\027\t\b \035\017\021\036\030\026\021\031\030\t \002\t\035\026 \f\ \024)Tj 0 Tw (-)Tj 0.279 Tw T* (\f\021\026\r\035\036\027\026 \021\026\002\035\017\006\026, \r)Tj /Span<>> BDC ( )Tj EMC (\022\024\021\024\030\024\005 \024\021\030\026\032\036\027\t \030\026\035\ \017\004\027\t\036 )Tj 0.593 Tw T* (\022\035\017\027\017\004\036\f\022\017\036 \023\030\024\016\r\035\036\027\ \017\016 \f\017\027\007\030\024\n\026 \033\r\036\027\017\035\034\027\024\ \020\024 )Tj 0.205 Tw T* (\023\024\035\017\023\024\026 \031)Tj /Span<>> BDC ( )Tj EMC (\021\036\b 40\22660% \023\026\006\017\036\027\021\024\r, \031)Tj /Span<>> BDC ( )Tj EMC (\022\024\021\024\030\t\b \031\007\026)Tj 0 Tw (-)Tj 0.386 Tw T* (\035\024\f\034 \r\t\016\r\017\021\034 \020\036\027\036\021\017\004\036\f\ \022\031\033 \023\030\017\004\017\027\031 \026\002\024\035\036\r\026\027\ \017\016 )Tj 0 Tw T* (\(\230\026\002\035.)Tj /Span<>> BDC ( )Tj EMC (1\).)Tj 0.193 Tw T* (\203\026 \f\036\020\024\007\027\016\001\027\017\005 \007\036\027\034 \007\ \035\016 \022\035\017\027\017\004\036\f\022\024\005 \023\024\f\021\026\027\ \024\r\022\017 )Tj 0.207 Tw T* (\007\017\026\020\027\024\026 \f\017\027\007\030\024\n\026 \033\r\036\027\ \017\035\034\027\024\020\024 \023\024\035\017\023\024\026 \027\036\024\002\ \b\024)Tj 0 Tw (-)Tj T* (\007\017\n\024 \027\026\035\017\004\017\036 \024\007\027\024\020\024 \017\ )Tj /Span<>> BDC ( )Tj EMC (\f\035\036\007\031\033\013\017\b \022\030\017\021\036\030\017\036\r [3]:\ )Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\214)10(\211\036\033 \035\030\032\t\033)30(\b)42(\032)-21(\240\033\233)]TJ 57.136 0 Td (REVIEW)Tj -57.136 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 23, \023\0221)69(, 202)69(4)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 23, \023\0221)69(, 202)69(4)]TJ /T1_5 1 Tf 25 0 0 25 20.9403 56.0378 Tm (144)Tj ET endstream endobj 919 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\021\220\001\201\002\025\024 \212\r\016\001\220\007\216\001\025\202)10(\025 \221\025\007\220\221\025)21(\222\013 \(\025\f\222\025\002 \007\220\026)11(\016\002\013\026)-20(\215\002\020\))]TJ 45.723 0 Td [(Ju)10(v)12(enile polyposis s)10(yndr)20(ome \(r)31(e)11(vie)11(w\))]TJ ET 0 0 0 1 K /GS1 gs q 1 0 0 1 42.5197 711.1159 cm 0 0 m 453.543 0 l S Q BT 0 0 0 1 k /T1_1 1 Tf 0.01 Tc -0.016 Tw 8 0 0 8 42.5596 731.2159 Tm [(ADDRESS)4.9( F)13(OR)5( C)19(ORRESPONDEN)23(CE:)]TJ /T1_2 1 Tf 0 Tc -0.011 Tw 13.983 0 Td [( T)54(atyana A. Vlask)13.1(o, Ryzhikh N)18(ational Medical R)21.1(esearch Center of Colop)46.1(roctology)42(, Salyama Adilya st., 2, Moscow)52.1(, )]TJ 0.023 Tw -13.987 -1.2 Td [(123423, R)22(ussia; e-mail: ta.vlask)13(o@yande)-14.9(x.ru)]TJ 0 Tw 0 -2.792 TD (\200\026\024\026 \033\n\t\024\205\033\023\031\021\025\002)Tj /Span<>> BDC ( )Tj EMC (\227 21.11.2023)Tj /Span<>> BDC ( )Tj EMC 19.488 0 Td (\n\t\023\031 \030\n\032\026\005\n\024\013\025)Tj /Span<>> BDC ( )Tj EMC (\227 25.12.2023)Tj /Span<>> BDC ( )Tj EMC 18.78 0 Td (\032\025\021\002\024\n \013)Tj /Span<>> BDC ( )Tj EMC (\033\205\005\023\025\013\026\203\025\025)Tj /Span<>> BDC ( )Tj EMC (\227 12.02.2024)Tj ( )Tj -38.268 -1.375 Td (Received)Tj /Span<>> BDC ( )Tj EMC (\227 21.11.2023)Tj /Span<>> BDC ( )Tj EMC 19.488 0 Td (Revised)Tj /Span<>> BDC ( )Tj EMC (\227 25.12.2023)Tj /Span<>> BDC ( )Tj EMC 18.78 0 Td (Accepted for publication)Tj /Span<>> BDC ( )Tj EMC (\227 12.02.2024)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 42.5896 651.7618 Tm (\023\023\034\226\034\022\031\034)Tj 0 0 0 1 k /GS1 gs /T1_4 1 Tf 0 Tc 0.43 Tw 10 0 0 10 42.5197 627.4058 Tm (\221\017\027\007\030\024\n \033\r\036\027\017\035\034\027\024\020\024 \023\ \024\035\017\023\024\026 \(\221\236\215\))Tj /Span<>> BDC ( )Tj EMC (\227 \022\030\026\005)Tj 0 Tw (-)Tj 0.232 Tw 0 -1.218 TD (\027\036 \030\036\007\022\024\036 \026\002\024\035\036\r\026\027\017\036\ \(\030\026\f\023\030\024\f\021\030\026\027\036\027\027\024\f\021\034 1:\ 100 )Tj 0.139 Tw T* (000)Tj /Span<>> BDC ( )Tj EMC (\227 1:160 000\) \f)Tj /Span<>> BDC ( )Tj EMC (\026\031\021\024\f\024\n\027\024-\007\024\n\017\027\026\027\021\027\t\n \ \021\017\023\024\n )Tj 0.041 Tw T* [(\027\026\f\035\036\007\024\r\026\027\017\016, )0.6(\b\026\030\026\022\021\036\030\017\031\033\013\036\036\f\016 )0.5(\027\026\035\017\004\017\036\n )0.5(\n\027\024\032\036)]TJ 0 Tw (-)Tj 0.128 Tw T* (\f\021\r\036\027\027\t\b \023\024\035\017\023\024\r \r)Tj /Span<>> BDC ( )Tj EMC (\030\026\035\017\004\027\t\b \024\021\007\036\035\026\b \032\036\035\031\ \007\024\004\027\024-)Tj -0.042 Tw T* (\022\017\001\036\004\027\024\020\024 \021\030\026\022\021\026, \023\030\036\ \017\n\031\013\036\f\021\r\036\027\027\024, \r)Tj /Span<>> BDC ( )Tj EMC (\021\024\035\f\021\024\005 \022\017\001\022\036 )Tj 0 Tw T* (\(98%\) [1\2264].)Tj -0.033 Tw T* (\230\024\035\034\022\024 \r)Tj /Span<>> BDC ( )Tj EMC (40\22660% \f\035\031\004\026\036\r \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\n\024\035\036\022\031\035\016\030\027\024-\020\036\027\036\021\017\004\036\ )Tj 0 Tw (-)Tj -0.094 Tw T* (\f\022\024\n \017\f\f\035\036\007\024\r\026\027\017\017 \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \031\007\026\036\021\f\016 \r\t\016\r\ \017\021\034 \023\026\021\024)Tj 0 Tw (-)Tj -0.029 Tw T* [(\020\036\027\027\t\036 )0.5(\r\026\030\017\026\027\021\t )0.6(\020\036\027\024\r )]TJ /T1_2 1 Tf 0 Tw 9.801 0 Td (SMAD4 )Tj /T1_4 1 Tf 2.894 0 Td (\017)Tj /T1_2 1 Tf -0.029 Tw /Span<>> BDC ( )Tj EMC 0.721 0 Td [(BMP)66(R1A, )]TJ /T1_4 1 Tf 3.6 0 Td [(\007\035\016 )0.5(\022\026\032\007\024\020\024 )]TJ 0.163 Tw -17.018 -1.218 Td (\017)Tj /Span<>> BDC ( )Tj EMC (\022\024\021\024\030\t\b \b\026\030\026\022\021\036\030\027\t \f\r\024\017\ \022\035\017\027\017\004\036\f\022\017\036 \023\030\024\016\r\035\036)Tj 0 Tw (-)Tj -0.025 Tw T* (\027\017\016 [5])Tj /T1_2 1 Tf 0 Tw (. )Tj /T1_4 1 Tf -0.025 Tw 3.453 0 Td (\215\024)Tj /Span<>> BDC ( )Tj EMC (\007\026\027\027\t\n Jelsig A.M. \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021., \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\f\017\027\007\030\024\n\036 )Tj 0.213 Tw -3.453 -1.218 Td (\033\r\036\027\017\035\034\027\024\020\024 \023\024\035\017\023\024\026\ , \024\002\031\f\035\024\r\035\036\027\027\024\n \023\026\021\024\020\036\ \027\027\t\n )Tj 0.049 Tw T* (\r\026\030\017\026\027\021\024\n \020\036\027\026 )Tj /T1_2 1 Tf 0 Tw (SMAD4,)Tj /T1_4 1 Tf 0.049 Tw ( \004\026\013\036 \r\f\021\030\036\004\026\036\021\f\016 \023\024\030\026\ \032\036\027\017\036 )Tj -0.06 Tw T* (\r\036\030\b\027\017\b \024\021\007\036\035\024\r \240\025\230 \(\r 70% \ \f\035\031\004\026\036\r\), \026)Tj /Span<>> BDC ( )Tj EMC (\r \023\031\002\035\017\022\026\006\017\017 )Tj 0.058 Tw T* [(Bl)-16(a)15(t)-30(ter R. \017)]TJ /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. \024\021\n\036\004\026\036\021\f\016, \004\021\024 \f\024\ \004\036\021\026\027\017\036 \f)Tj /Span<>> BDC ( )Tj EMC (\f\017\027\007)Tj 0 Tw (-)Tj 0.172 Tw T* (\030\024\n\024\n \027\026\f\035\036\007\f\021\r\036\027\027\t\b \020\036\ \n\024\030\030\026\020\017\004\036\f\022\017\b \021\036\035\036\026\027\020\ \017\024)Tj 0 Tw (-)Tj 0.015 Tw T* (\220\022\021\026\017\005)Tj /Span<>> BDC ( )Tj EMC (\227 \002\024\035\036\027\034\033 \217\036\027\007\033-\210\f\035\036\030\ \026-\200\036\002\036\030\026 \031)Tj /Span<>> BDC ( )Tj EMC (\007\026\027\027\024\005 )Tj 0 Tw T* (\020\030\031\023\023\t \023\026\006\017\036\027\021\024\r \024\023\030\036\ \007\036\035\016\036\021\f\016 \r)Tj /Span<>> BDC ( )Tj EMC (30% \f\035\031\004\026\036\r [6,7].)Tj 0.143 Tw T* (\200 70% \f\035\031\004\026\036\r \023\030\017)Tj /Span<>> BDC ( )Tj EMC [(\023\024\030\026\032\036\027\017\017 )0.5(\021\024\035\f\021\024\005 \022\017\001\022\017 \033\r\036)]TJ 0 Tw (-)Tj 0.094 Tw T* (\027\017\035\034\027\t\036 \023\024\035\017\023\t \035\024\022\026\035\017\ \024\r\026\027\t \r)Tj /Span<>> BDC ( )Tj EMC (\023\030\016\n\024\005 \017)Tj /Span<>> BDC ( )Tj EMC (\007\017\f\021\026\035\034)Tj 0 Tw (-)Tj 0.356 Tw T* (\027\024\005 \004\026\f\021\017 \f\017\020\n\024\r\017\007\027\024\005 \022\ \017\001\022\017, \017\n\036\033\021 \021\036\027\007\036\027\006\017\033\ )Tj -0.02 Tw T* (\022)Tj /Span<>> BDC ( )Tj EMC (\022\030\024\r\024\021\024\004\017\r\024\f\021\017, \f\026\n\024\026\n\023\ \031\021\026\006\017\017 \017)Tj /Span<>> BDC ( )Tj EMC (\022 \r\t\023\026\007\036\027\017\033 [8]. )Tj 0.313 Tw T* [(\215\036\030\r\t\036 \022\035\017\027\017\004\036\f\022\017\036 )0.5(\023\030\024\016\r\035\036\027\017\016 \026\002\024\035\036\r\026\027\017\ \016 \027\036)]TJ 0 Tw (-)Tj 0.122 Tw T* (\f\023\036\006\017\235\017\004\027\t \017)Tj /Span<>> BDC ( )Tj EMC (\004\026\013\036 \r\f\036\020\024 \r\024\027\017\022\026\033\021 \007\024\ )Tj /Span<>> BDC ( )Tj EMC (20-\035\036\021\027\036\020\024 )Tj 0 Tw T* (\r\024\030\026\f\021\026.)Tj 0.059 Tw T* (\230\030\031\007\027\024\f\021\034 \r)Tj /Span<>> BDC ( )Tj EMC (\r\t\016\r\035\036\027\017\017 \007\026\027\027\024\020\024 \026\002\024\ \035\036\r\026\027\017\016 \026\022\035\033)Tj 0 Tw (-)Tj 0.028 Tw T* (\004\026\036\021\f\016 \r)Tj /Span<>> BDC ( )Tj EMC (\021\024\n, \004\021\024 \002\024\035\036\036 \004\036\n \031)Tj /Span<>> BDC ( )Tj EMC (50% \023\026\006\017\036\027\021\024\r \023\024\n\017\n\024 )Tj 0.087 Tw T* (\033\r\036\027\017\035\034\027\t\b \023\024\035\017\023\024\r \r\f\021\030\ \036\004\026\033\021\f\016 \017)Tj /Span<>> BDC ( )Tj EMC (\026\007\036\027\024\n\026\021\024\027\t\036, )Tj 0.68 Tw T* (\004\021\024 \026\021\030\031\007\027\016\036\021 \023\030\024\r\036\007\ \036\027\017\036 \007\017\235\235\036\030\036\027\006\017\026\035\034\027\ \024\020\024 )Tj 0 Tw T* (\007\017\026\020\027\024\026 \f)Tj /Span<>> BDC ( )Tj EMC (\f\036\n\036\005\027\t\n \026\007\036\027\024\n\026\021\024\024\n [9,10\ ].)Tj 0.174 Tw T* (\215\030\017 \026\027\026\035\017\036 \035\017\021\036\030\026\021\031\030\ \027\t\b \017\f\021\024\004\027\017\022\024\r \r\t\016\f\027\017\035\024\ \f\034, )Tj 0.41 Tw T* (\004\021\024 \220\027\007\024\f\022\024\023\017\004\036\f\022\017\036 \b\ \026\030\026\022\021\036\030\017\f\021\017\022\017 \033\r\036\027\017\035\ \034\027\t\b )Tj 0.058 Tw T* (\023\024\035\017\023\024\r \024\021\030\026\032\036\027\t \021\024\035\034\ \022\024 \r)Tj /Span<>> BDC ( )Tj EMC (\036\007\017\027\017\004\027\t\b \023\031\002\035\017\022\026\006\017\016\ \b )Tj 0 Tw T* ([11,12].)Tj 0.063 Tw T* (\221\030\036\007\017 \r\f\036\b \023\024\035\017\023\024\027\t\b \f\017\ \027\007\030\024\n\024\r \r)Tj /Span<>> BDC ( )Tj EMC (\030\026\r\017\021\017\017 \022\024\035\024)Tj 0 Tw (-)Tj 0.215 Tw T* (\030\036\022\021\026\035\034\027\024\020\024 \030\026\022\026 \r\022\035\ \026\007 \221\236\215 \f\024\f\021\026\r\035\016\036\021 \n\036\027\036\036\ 1% )Tj 0.099 Tw T* ([13]. \215\030\017)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\n \030\017\f\022 \030\026\r\017\021\017\016 \022\024\035\024\ \030\036\022\021\026\035\034\027\024\020\024 \030\026\022\026 )Tj 0.161 Tw T* (\023\030\017)Tj /Span<>> BDC ( )Tj EMC (\007\026\027\027\024\n \026\002\024\035\036\r\026\027\017\017 \f\024\f\021\ \026\r\035\016\036\021 \007\024)Tj /Span<>> BDC ( )Tj EMC (50%, \021\026\022\032\036 )Tj -0.037 Tw T* (\035\017\006\026 \f)Tj /Span<>> BDC ( )Tj EMC (\007\026\027\027\t\n \f\017\027\007\030\024\n\024\n \023\024\007\r\036\030\ \032\036\027\t \023\024\r\t\001\036\027\027\024\n\031 )Tj 0.074 Tw T* [(\030\017\f\022\031 )0.5(\030\026\r\017\021\017\016 )0.6(\030\026\022\026 )0.5(\032\036\035\031\007\022\026 )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC 13.52 0 Td (\007\r\036\027\026\007\006\026\021\017\023\036\030\f\021\027\024\005 )Tj 0.035 Tw -13.52 -1.218 Td (\022\017\001\022\017)Tj /Span<>> BDC ( )Tj EMC 2.895 0 Td [(\227 )0.5(\024\021 )0.5(11 )0.5(\007\024)]TJ /Span<>> BDC ( )Tj EMC 4.945 0 Td [(20% )0.5([14\22616]. )0.6(\200\026\032\027\024 )0.5(\024\021\n\036\021\017\021\034, )0.6(\004\021\024 )]TJ 0.213 Tw -7.84 -1.218 Td (\r\027\036\022\017\001\036\004\027\t\036 \r\017\007\t \030\026\022\026 \031\ )Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\f\017\027\007\030\024\n\024\n )Tj 0 Tw T* (\033\r\036\027\017\035\034\027\024\020\024 \023\024\035\017\023\024\026\ \027\036 \024\023\017\f\026\027\t.)Tj -0.138 Tw T* (\211\004\017\021\t\r\026\016 \030\036\007\022\031\033 \r\f\021\030\036\004\ \026\036\n\024\f\021\034 \007\026\027\027\024\020\024 \026\002\024\035\036\ \r\026\027\017\016, )Tj 0.387 Tw T* (\r\024\023\030\024\f\t \r\t\016\r\035\036\027\017\016 \b\026\030\026\022\ \021\036\030\027\t\b \007\017\026\020\027\024\f\021\017\004\036\f\022\017\ \b )Tj 0.197 Tw 23.244 57.237 Td (\023\030\017\027\026\022\024\r, \026)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\032\036 \017\031\004\036\027\017\016 \n\036\b\026\027\017\ \n\024\r \030\026\r\017\021\017\016 )Tj 0.27 Tw T* (\022\024\035\024\030\036\022\021\026\035\034\027\024\020\024 \030\026\022\ \026 \031)Tj /Span<>> BDC ( )Tj EMC (\007\026\027\027\024\005 \020\030\031\023\023\t \023\026\006\017\036\027\ \021\024\r )Tj 0.15 Tw T* (\024\f\021\026\033\021\f\016 \024\021\022\030\t\021\t\n\017. \203\026)Tj /Span<>> BDC ( )Tj EMC (\f\036\020\024\007\027\016\001\027\017\005 \007\036\027\034 \022)Tj /Span<>> BDC ( )Tj EMC (\r\026\030\017)Tj 0 Tw (-)Tj 0.132 Tw T* (\026\027\021\026\n \035\036\004\036\027\017\016 \024\021\027\024\f\016\021\ \220\027\007\024\f\022\024\023\017\004\036\f\022\024\036 \017)Tj /Span<>> BDC ( )Tj EMC (\b\017\030\031\030\020\017)Tj 0 Tw (-)Tj 0.198 Tw T* [(\004\036\f\022\024\036, )0.5(\024\007\027\026\022\024 \026\035\020\024\030\017\021\n \023\030\017\027\ \016\021\017\016 )0.5(\030\036\001\036\027\017\005, )0.5(\026)]TJ /Span<>> BDC ( )Tj EMC (\021\026\022)Tj 0 Tw (-)Tj 0.198 Tw T* (\032\036 \f\030\024\022\017 \023\024\f\035\036\024\023\036\030\026\006\017\ \024\027\027\024\020\024 \027\026\002\035\033\007\036\027\017\016 \036\013\ \036 \027\036 )Tj 0 Tw T* (\030\026\030\026\002\024\021\026\027\t.)Tj /T1_5 1 Tf 0 -2.436 TD (\034\217\003\002\006\t\201\r\217\220\t\r \004\217\212\r\220\003\013)Tj /T1_4 1 Tf 0.102 Tw 0 -1.218 TD (\215\036\030\r\024\036 \024\023\017\f\026\027\017\036 \033\r\036\027\017\ \035\034\027\t\b \023\024\035\017\023\024\r, \r\t\016\r\035\036\027\027\t\ \b )Tj 0.062 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\023\030\016\n\024\005 \022\017\001\022\036 30-\n\036\f\016\004\027\024\020\ \024 \030\036\002\036\027\022\026, \002\t\035\024 \r\t\023\024\035)Tj 0 Tw (-)Tj 0.069 Tw T* (\027\036\027\024 \r)Tj /Span<>> BDC ( )Tj EMC (1939 \020\024\007\031 [17]. \230\036\030\n\017\027 \253\033\r\036\027\017\ \035\034\027\t\005 \023\024\035\017\023\273 )Tj 0.157 Tw T* (\r\023\036\030\r\t\036 \r\f\021\030\036\004\026\036\021\f\016 \r)Tj /Span<>> BDC ( )Tj EMC [(\023\031\002\035\017\022\026\006\017\017 Hor)-23.9(r)-37(illeno e)-12(t al. )]TJ 0.056 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (1957 \020\024\007\031 [18]. \202\r\021\024\030\t \024\023\017\f\026\035\017\ \030\036\031\035\034\021\026\021\t \024\002\f\035\036)Tj 0 Tw (-)Tj 0.058 Tw T* (\007\024\r\026\027\017\005 \f)Tj /Span<>> BDC ( )Tj EMC (1935 \023\024)Tj /Span<>> BDC ( )Tj EMC (1955 \020\020. \023\016\021\017\007\036\f\016\021\017 \023\016\021\017 \023\ \026\006\017\036\027)Tj 0 Tw (-)Tj T* (\021\024\r \r)Tj /Span<>> BDC ( )Tj EMC (\r\024\030\026\f\021\036 1\22614)Tj /Span<>> BDC ( )Tj EMC (\035\036\021 \f)Tj /Span<>> BDC ( )Tj EMC (\033\r\036\027\017\035\034\027\t\n\017 \023\024\035\017\023\026\n\017.)Tj 0.043 Tw T* [(V)30(eale e)-12(t al. \r)]TJ /Span<>> BDC ( )Tj EMC (1966 \020\024\007\031 \r\t\007\036\035\017\035\017 \024\021\035\017\004\017\ \021\036\035\034\027\t\036 \n\026)Tj 0 Tw (-)Tj -0.041 Tw T* (\022\030\024\f\022\024\023\017\004\036\f\022\017\036 \017)Tj /Span<>> BDC ( )Tj EMC (\020\017\f\021\024\035\024\020\017\004\036\f\022\017\036 \024\f\024\002\036\ \027\027\024\f\021\017 \033\r\036)Tj 0 Tw (-)Tj T* (\027\017\035\034\027\t\b \023\024\035\017\023\024\r [19].)Tj 0.323 Tw T* (\222\027\026\004\026\035\034\027\024 \026\002\024\035\036\r\026\027\017\ \036 \021\030\026\022\021\024\r\026\035\024\f\034, \022\026\022 \b\026\030\ \026\022)Tj 0 Tw (-)Tj 0.151 Tw T* [(\021\036\030\027\024\036 )0.5(\007\035\016 )0.6(\023\026\006\017\036\027\021\024\r )0.5(\n\035\026\007\001\036\005 )0.6(\r\024\030\026\f\021\027\024\005 )0.5(\020\030\031\023\023\t. )]TJ 0.547 Tw T* (\212\036\005\f\021\r\017\021\036\035\034\027\024, \033\r\036\027\017\035\ \034\027\t\036 \023\024\035\017\023\t \r\f\021\030\036\004\026\033\021\f\ \016 )Tj -0.006 Tw T* (\031)Tj /Span<>> BDC ( )Tj EMC (2% \007\036\021\036\005 \017)Tj /Span<>> BDC ( )Tj EMC (\023\024\007\030\024\f\021\022\024\r, \f\024\f\021\026\r\035\016\016 80\226\ 90% \024\021 \024\002\013\036)Tj 0 Tw (-)Tj 0.171 Tw T* (\020\024 \022\024\035\017\004\036\f\021\r\026 \023\024\035\017\023\024\r\ \031)Tj /Span<>> BDC ( )Tj EMC (\007\026\027\027\024\005 \020\030\031\023\023\t \023\026\006\017\036\027\ \021\024\r )Tj 0.486 Tw T* ([20,21]. \221\023\024\030\026\007\017\004\036\f\022\017\036 \(\036\007\017\ \027\017\004\027\t\036\) \033\r\036\027\017\035\034\027\t\036 )Tj 0.1 Tw T* (\023\024\035\017\023\t \021\024\035\f\021\024\005 \022\017\001\022\017 \r\ \f\021\030\036\004\026\033\021\f\016 \031)Tj /Span<>> BDC ( )Tj EMC (2% \023\026\006\017\036\027\021\024\r )Tj -0.012 Tw T* (\007\036\021\f\022\024\020\024 \r\024\030\026\f\021\026, \026)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\032\036 \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \f\021\026\030\001\036 18 \035\036\021\ )Tj 0.139 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC 0.889 0 Td [(\027\036 )0.5(\f\r\016\026\027\t )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC 5.929 0 Td [(\023\024\r\t\001\036\027\027\t\n )0.6(\030\017\f\022\024\n )0.5(\030\026\022\026 )0.5(\032\036\035\031\007\024\004)]TJ 0 Tw (-)Tj -0.022 Tw -6.819 -1.218 Td (\027\024-\022\017\001\036\004\027\024\020\024 \021\030\026\022\021\026 [\ 22\22624]. \230\036\030\n\017\027 \253\033\r\036\027\017\035\034\027\t\005\ \273 )Tj 0.123 Tw T* (\024\023\030\036\007\036\035\016\036\021 \020\017\f\021\024\035\024\020\017\ \004\036\f\022\031\033 \f\021\030\031\022\021\031\030\031 \023\024\035\017\ \023\026, \026)Tj /Span<>> BDC ( )Tj EMC (\027\036 )Tj 0 Tw T* (\r\024\030\026\f\021\027\t\036 \024\f\024\002\036\027\027\024\f\021\017\ \026\002\024\035\036\r\026\027\017\016 [10].)Tj /T1_5 1 Tf 0 -2.436 TD (\027\r\b\r\003\t\201\r\217\220\t\r \004\217\212\r\220\003\013 \213\004\206\ \002\f\r\004\b\t\235)Tj /T1_4 1 Tf 0.323 Tw 0 -1.218 TD (\203\026 \f\036\020\024\007\027\016\001\027\017\005 \007\036\027\034 \212\ \203\025-\007\017\026\020\027\024\f\021\017\022\026 \023\024\r\024\035\016\ \036\021 )Tj 0.111 Tw T* (\027\026\005\021\017 \020\036\027\036\021\017\004\036\f\022\031\033 \023\ \030\017\004\017\027\031 \026\002\024\035\036\r\026\027\017\016 \027\036\ \031)Tj /Span<>> BDC ( )Tj EMC (\r\f\036\b )Tj 0.548 Tw T* (\023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\f\017\027\007\030\024\n\024\n \033\r\036\027\017\035\034\027\024\020\024\ \023\024\035\017\023\024\026. )Tj 0.089 Tw T* (\230\024\035\034\022\024 \r)Tj /Span<>> BDC ( )Tj EMC (40\22660% \f\035\031\004\026\036\r \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\221\236\215 \031\007\026\036\021)Tj 0 Tw (-)Tj 0.199 Tw T* (\f\016 \r\t\016\r\017\021\034 \023\026\021\024\020\036\027\027\t\036 \r\026\ \030\017\026\027\021\t \020\036\027\024\r )Tj /T1_2 1 Tf 0 Tw (SMAD4)Tj /T1_4 1 Tf 0.199 Tw ( \017\035\017 )Tj /T1_2 1 Tf 0 Tw T* [(BMP)66(R1A, )]TJ /T1_4 1 Tf 0.021 Tw 3.651 0 Td (\022\024\021\024\030\t\036 \030\026\f\023\024\035\024\032\036\027\t \027\ \026)Tj /Span<>> BDC ( )Tj EMC (\b\030\024\n\024\f\024\n\026\b 18q21 )Tj -0.047 Tw -3.651 -1.218 Td (\017)Tj /Span<>> BDC ( )Tj EMC (10q22, \f\024\024\021\r\036\021\f\021\r\036\027\027\024 [5]. \215\030\017\ \n\036\030\027\024 \r)Tj /Span<>> BDC ( )Tj EMC (20\22630% \f\035\031)Tj 0 Tw (-)Tj 0.066 Tw T* (\004\026\036\r \221\236\215 \024\002\031\f\035\024\r\035\036\027 \023\026\ \021\024\020\036\027\027\t\n\017 \r\026\030\017\026\027\021\026\n\017 \020\ \036\027\026 )Tj /T1_2 1 Tf 0 Tw T* [(BMP)66(R1A, )]TJ /T1_4 1 Tf -0.036 Tw 3.594 0 Td (\026)Tj /Span<>> BDC ( )Tj EMC (\r 20\22630%)Tj /Span<>> BDC ( )Tj EMC (\227 \023\026\021\024\020\036\027\027\t\n\017 \r\026\030\017\026\027\021\ \026\n\017 \020\036\027\026 )Tj /T1_2 1 Tf 0 Tw -3.594 -1.218 Td (SMAD4. )Tj /T1_4 1 Tf -0.038 Tw 3.182 0 Td (\210\002\026 \020\036\027\026 \016\r\035\016\033\021\f\016 \f\031\023\030\ \036\f\f\024\030\026\n\017 \024\023\031\b\024\035\036\r\024\020\024 )Tj 0.081 Tw -3.182 -1.218 Td (\030\024\f\021\026, \031\004\026\f\021\r\031\033\021 \r)Tj /Span<>> BDC ( )Tj EMC [(\f\017\020\027\026\035\034\027\t\b \023\031\021\016\b bonemor)-24(pho)-16(ge)]TJ 0 Tw (-)Tj 0.164 Tw T* [(ne)-12(t)-32(ic p)25(r)-31.9(o)17(tein \(BMP\) \017)]TJ /Span<>> BDC ( )Tj EMC (\021\030\026\027\f\235\024\030\n\017\030\031\033\013\036\020\024 \235\026\ \022\021\024\030\026 )Tj 0.043 Tw T* [(\030\024\f\021\026-\002\036\021\026 \(T)35(GF-\256\), \022\024\021\024\030\t\036 \r\035\017\016\033\021 \027\026)]TJ /Span<>> BDC ( )Tj EMC (\021\026\022\017\036 \022\035\036\021\024\004)Tj 0 Tw (-)Tj 0.011 Tw T* (\027\t\036 \023\030\024\006\036\f\f\t, \022\026\022 \030\024\f\021, \007\ \017\235\235\036\030\036\027\006\017\030\024\r\022\026 \017)Tj /Span<>> BDC ( )Tj EMC (\026\023\024\023\021\024 )Tj 0 Tw T* ([5])Tj /T1_2 1 Tf (. )Tj /T1_4 1 Tf 0.429 Tw 2.198 0 Td (\207\024\035\034\001\017\027\f\021\r\024 \r\026\030\017\026\027\021\024\r\ \023\030\036\007\f\021\026\r\035\016\033\021 \f\024\002\024\005 )Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 0 Tw 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\214)10(\211\036\033 \035\030\032\t\033)30(\b)42(\032)-21(\240\033\233)]TJ 57.136 0 Td (REVIEW)Tj /T1_6 1 Tf 25 0 0 25 505.5646 56.0378 Tm (143)Tj ET endstream endobj 915 0 obj [926 0 R] endobj 916 0 obj <>stream q /GS0 gs /Fm0 Do Q 0 0 0 1 K 1 j 1 J [0 2.997]0 d /GS1 gs q 1 0 0 1 74.3631 425.0103 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 71.3661 425.0103 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q [0 2.997]0 d q 1 0 0 1 74.3631 397.4025 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 71.3661 397.4025 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q [0 2.997]0 d q 1 0 0 1 74.3631 140.9176 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 71.3661 140.9176 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q [0 2.997]0 d q 1 0 0 1 74.3631 113.3097 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 71.3661 113.3097 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q BT 0 0 0 1 k /T1_0 1 Tf 10 0 0 10 70.8661 724.8299 Tm (https://doi.org/10.33878/2073-7556-2024-23-1-142-151)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0.023 Tw 19 0 0 19 87.0717 695.3259 Tm [(\021\220\001\201\002\025\024 \212\r\016\001\220\007\216\001\025\202)10.1(\025 \221\025\007\220\221\025)21.1(\222\013 \(\025\f\222\025\002 \007\220\026)11(\016\002\013\026)-20(\215\002\020\))]TJ 0 0 0 1 k /GS1 gs 0 Tw 14 0 0 14 70.8661 670.822 Tm [(\004\007\013\006\n)10(\025\022)-23.2(\032.\b)-31(.)]TJ 8.162 0 0 8.162 137.8312 675.484 Tm (1)Tj 0.023 Tw 14 0 0 14 142.4671 670.822 Tm [(, \035\220\n\215)-20(\026)11.1(\025\r\022)-23.3(\b)-31(.\b)-31(.)]TJ -0.069 Tc 0.069 Tw 8.162 0 0 8.162 228.3637 675.484 Tm [(1,)-69(2)]TJ 0 Tc 0.023 Tw 14 0 0 14 239.6843 670.822 Tm [(, \004\016\006\016\007\025\r\022)-23.2(\004.\004.)]TJ -0.069 Tc 0.069 Tw 8.162 0 0 8.162 320.051 675.484 Tm [(1,)-69(2)]TJ 0 Tc 0.023 Tw 14 0 0 14 331.3716 670.822 Tm [(, \034\025\001\025\024\013\002\016\001\n)10.1(\025\022)-23.3(\b)-31(.\b)-31(.)]TJ 0 Tw 8.162 0 0 8.162 450.2661 675.484 Tm (1)Tj 14 0 0 14 454.9021 670.822 Tm (, )Tj -27.431 -1.143 Td [(\226\215\n\013\001\025\r\022)-23.2(\b)-31(.\021.)]TJ 8.162 0 0 8.162 149.927 659.484 Tm (1)Tj 5.83 0 0 5.83 70.8661 640.4827 Tm (1)Tj 0.023 Tw 10 0 0 10 74.1775 637.1527 Tm [(\210\031\214)42(\240 \253\213\005\030\226 \n)10(\025\007\025\221\002\025\n)-9.9(\026)11(\025\007\025\202\220\220 \220\024\016\001\220 \b)-30.9(.\213.\022)-23.3(\033\020\217\220\207\273 \005\220\001\222\201\002\013\r\013 \033\025\006\ \006\220\220 \(\215\007.\022)-23.3(\021\013\007\205\024\013 \b)-20.9(\201\220\007\205, \201.\022)-23.3(2, \202)62.1(.\022)-23.3(\005\025\006\n\r\013, )]TJ -0.331 -1.2 Td [(1)125(23)58(423, \033\025\006\006\220\205\))]TJ 0 Tw ( )Tj 5.83 0 0 5.83 70.8661 616.4827 Tm (2)Tj 0.023 Tw 10 0 0 10 74.1775 613.1527 Tm [(\210\031\214)21(\036)20(\240 \255\034\036 \033)21(\005\b\213\034\036 \005\220\001\222\201\002\013\r\013 \033\025\006\006\220\ \220 \(\215\007.\022)-23.2(\214\013\002\002\220\n\013\201\001\013\205, \201.\022)-23.3(2/1)69(, \006)-10(\026\002)-31(.\022)-23.3(1)69(, \202)62(.\022)-23.2(\005\025\006\n\r\013, 1)125(2)23(5)23(99)35(3, \033\025\006\006\220\205\))]TJ /T1_0 1 Tf -0.023 Tw 9 0 0 9 119.0551 594.6488 Tm [(\255\005\016\n\032 \023\025\024\031\032\026\024\205\032\020 )0.5(\033\n\t\027\002\211\031\021 )0.5(\n\033\025\t\026\021\025\007 \t\025\021\030\032\n\003\026 )0.5(\007\027\031\021\025\023\022\021\n\202\n )0.5(\033\n\023\025\033\n\016\026 \(\207\223\), \013\032\026\017\021\031 \032\ \031\030\013\n\202\n \016\026\005\n\023\031\027\026\021\025\002 )]TJ -0.054 Tw 0 -1.111 TD (\t)Tj /Span<>> BDC ( )Tj EMC 0.572 0 Td [(\026\205\024\n\t\n\003\021\n-\030\n\003\025\021\026\021\024\021\020\003 \ )0.6(\024\025\033\n\003 )0.5(\021\026\t\023\031\030\n\027\026\021\025\002, )0.6(\013\n\024\n\032\n\031 )0.6(\004\026\032\026\013\024\031\032\025\016\205\031\024\t\002 )0.5(\021\026\023\025\006\025\031\003 )0.5(\003\021\n\204\031\t\024\027\031\021\021\020\004 )0.5(\033\n\023\025)]TJ 0 Tw (-)Tj 0.102 Tw -0.572 -1.111 Td (\033\n\027 \027)Tj /Span<>> BDC ( )Tj EMC (\032\026\016\023\025\006\021\020\004 \n\024\030\031\023\026\004 \204\031\ \023\205\030\n\006\021\n-\013\025\001\031\006\021\n\202\n \024\032\026\013\ \024\026, \033\032\031\025\003\205\211\031\t\024\027\031\021\021\n \027)Tj /Span<>> BDC ( )Tj EMC (\024\n\023\t\024\n\017 \013\025\001\013\031. \216\020\002\027\023\031\021\ \025\031 )Tj 0.147 Tw T* (\026\030\031\021\n\003\026\024\n\016\021\020\004 \033\n\023\025\033\n\027\ \205)Tj /Span<>> BDC ( )Tj EMC (\033\026\203\025\031\021\024\n\027 \t)Tj /Span<>> BDC ( )Tj EMC (\207\223 \033\n\003\025\003\n \007\027\031\021\025\023\022\021\020\004 \ \016\021\026\006\025\024\031\023\022\021\n \016\026\024\032\205\030\021\002\ \031\024 \030\025\026\202\021\n\t\024\025\013\205 )Tj -0.024 Tw T* (\016\026\005\n\023\031\027\026\021\025\002, \027)Tj /Span<>> BDC ( )Tj EMC (\024\n\003 \006\025\t\023\031 \033\032\n\027\031\030\031\021\025\031 \030\ \025\f\f\031\032\031\021\203\025\026\023\022\021\n\202\n \030\025\026\202\ \021\n\016\026 \t)Tj /Span<>> BDC ( )Tj EMC (\t\031\003\031\017\021\020\003 \026\030\031\021\n\003\026\024\n\016\n\003\ , \033\032\025)Tj /Span<>> BDC ( )Tj EMC (\013\n\024\n\032\n\003 )Tj 0.023 Tw 0 -1.111 TD (\021\031\n\005\004\n\030\025\003\n \027\020\033\n\023\021\002\024\022 \032\ \026\030\025\013\026\023\022\021\020\017 \n\005\b\031\003 \004\025\032\205\ \032\202\025\006\031\t\013\n\202\n \027\003\031\001\026\024\031\023\022\t\ \024\027\026)Tj /Span<>> BDC ( )Tj EMC (\227 \013\n\023\033\032\n\013\024\r\013\024\n\003\025\007.)Tj -0.032 Tw 0 -1.111 TD (\220\n\023\022\013\n \205)Tj /Span<>> BDC ( )Tj EMC (40\22660% \033\026\203\025\031\021\024\n\027 \205\030\026\031\024\t\002 \ \025\030\031\021\024\025\f\025\203\025\032\n\027\026\024\022 \033\026\024\ \n\202\031\021\021\020\031 \027\026\032\025\026\021\024\020 \202\031\021\ \n\027 SMAD4 \025)Tj /Span<>> BDC ( )Tj EMC (BMPR1A, \030\023\002 )Tj 0.023 Tw T* (\013\026\204\030\n\202\n \025\016)Tj /Span<>> BDC ( )Tj EMC (\013\n\024\n\032\020\004 \004\026\032\026\013\024\031\032\021\020 \t\027\ \n\025 \013\023\025\021\025\006\031\t\013\025\031 \033\032\n\002\027\023\ \031\021\025\002.)Tj 0.077 Tw T* (\222 \027\026\032\025\026\021\024\026\003 \023\031\006\031\021\025\002 \033\ \026\203\025\031\021\024\n\027 \t)Tj /Span<>> BDC ( )Tj EMC (\207\223 \n\024\021\n\t\002\024 \r\021\030\n\t\013\n\033\025\006\031\t\013\ \n\031 \025)Tj /Span<>> BDC ( )Tj EMC (\004\025\032\205\032\202\025\006\031\t\013\n\031, \n\030\021\026\013\n \026\ \023\202\n\032\025\024\003 \033\032\025)Tj 0 Tw (-)Tj 0.138 Tw T* (\021\002\024\025\002 \032\031\001\031\021\025\017, \026)Tj /Span<>> BDC ( )Tj EMC (\024\026\013\204\031 \t\032\n\013\025 \033\n\t\023\031\n\033\031\032\026\ \203\025\n\021\021\n\202\n \021\026\005\023\007\030\031\021\025\002 \021\ \031 \n\024\032\026\204\031\021\020 \027)Tj /Span<>> BDC ( )Tj EMC (\032\n\t\t\025\017\t\013\025\004 \013\023\025\021\025\006\031\t\013\025\004\ )Tj 0 Tw T* (\032\031\013\n\003\031\021\030\026\203\025\002\004.)Tj 0.099 Tw T* (\212\031\030\013\026\002 \027\t\024\032\031\006\026\031\003\n\t\024\022 \ \030\026\021\021\n\202\n \t\025\021\030\032\n\003\026, \024\032\205\030\021\ \n\t\024\025 \027)Tj /Span<>> BDC ( )Tj EMC (\r\021\030\n\t\013\n\033\025\006\031\t\013\n\017 \030\025\026\202\021\n\t\ \024\025\013\031 \025)Tj /Span<>> BDC ( )Tj EMC (\003\n\032\f\n\023\n\202\025\006\031\t\013\n\017 )Tj 0.023 Tw T* (\027\031\032\025\f\025\013\026\203\025\025, \026)Tj /Span<>> BDC ( )Tj EMC (\024\026\013\204\031 \n\202\032\026\021\025\006\031\021\025\002 \027)Tj /Span<>> BDC ( )Tj EMC (\n\033\032\031\030\031\023\031\021\025\025 \003\n\023\031\013\205\023\002\ \032\021\n-\202\031\021\031\024\025\006\031\t\013\n\017 \033\032\025\006\ \025\021\020 \016\026\005\n\023\031\027\026\021\025\002 \030\031\003\n\021\ )Tj 0 Tw (-)Tj 0.023 Tw T* (\t\024\032\025\032\205\007\024 \021\031\n\005\004\n\030\025\003\n\t\024\022\ \033\032\n\027\031\030\031\021\025\002 \030\026\023\022\021\031\017\001\ \025\004 \025\t\t\023\031\030\n\027\026\021\025\017.)Tj /T1_2 1 Tf 0.01 Tc 0.018 Tw 8 0 0 8 70.9061 449.3795 Tm [(\037\036\035\034\033\032\031\033)5( \030\036\027\032\026:)]TJ /T1_0 1 Tf 0 Tc 0.023 Tw 8.493 0 Td ( \007\027\031\021\025\023\022\021\020\017 \033\n\023\025\033\n\016, \202\ \026\003\026\032\024\n\003\021\020\017 \033\n\023\025\033, SMAD4, BMPR1A\ )Tj /T1_2 1 Tf 0.01 Tc 0.018 Tw -8.493 -1.909 Td [(\037\027\025\024\036\023\037\022)5( \023\025\022\033\021\033\030\027\032:)]TJ /T1_0 1 Tf 0 Tc 0.023 Tw 10.401 0 Td ( \026\027\024\n\032\020 \016\026\002\027\023\002\007\024 \n\005 \n\024\t\ \205\024\t\024\027\025\025 \013\n\021\f\023\025\013\024\026 \025\021\024\ \031\032\031\t\n\027)Tj /T1_2 1 Tf 0.033 Tc 0.107 Tw -10.401 -2.617 Td [(\020\036\017)4.7( \016\023\022\023\021\027\032\026\025\023\017:)]TJ /T1_3 1 Tf 0.023 Tc 0.113 Tw 9.28 0 Td [( )0.6(\200\035\026\f\022\024)]TJ /Span<>> BDC ( )Tj EMC 3.759 0 Td [(\230.\202., )0.6(\214\017\022\031\021\024\r)]TJ /Span<>> BDC ( )Tj EMC 6.169 0 Td [(\202.\202., )0.6(\200\036\f\036\035\024\r)]TJ /Span<>> BDC ( )Tj EMC 6.267 0 Td [(\200.\200., )0.6(\215\024\027\024\n\026\030\036\027\022\024)]TJ /Span<>> BDC ( )Tj EMC 8.566 0 Td [(\202.\202., )0.6(\037\031\022\026\027\024\r)]TJ /Span<>> BDC ( )Tj EMC 6.363 0 Td [(\202.\221. )0.6(\221\017\027\007\030\024\n )0.6(\033\r\036\027\017\035\034\027\024\020\024 )0.6(\023\024\035\017\023\024\026)23( )]TJ 0.024 Tw -40.409 -1.2 Td (\(\024\002\024\030 \035\017\021\036\030\026\021\031\030\t\). )Tj /T1_0 1 Tf -0.023 Tw (\222\n\023\n\033\032\n\013\024\n\023\n\202\025\002.)Tj /T1_3 1 Tf 0.024 Tw [( )0.5(2024; )0.5(\021.)]TJ /Span<>> BDC ( )Tj EMC (23, \225)Tj /Span<>> BDC ( )Tj EMC (1, \f.)Tj /Span<>> BDC ( )Tj EMC (142\226151. https://doi.org/10.33878/2073-7556-2024-23-1-142-151)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0 Tc 0.023 Tw 18 0 0 18 164.2609 371.2332 Tm [(Ju)10(v)12(enile polyposis s)10(yndr)20.1(ome \(r)31(e)11(vie)11(w\))]TJ 0 0 0 1 k /GS1 gs 0 Tw 14 0 0 14 70.8661 346.7292 Tm [(T)40(at)-20(y)21(ana\022)-23.2(A)-31(.\022)-23.3(Vlask)11(o)]TJ 8.162 0 0 8.162 173.2127 351.3912 Tm (1)Tj 0.023 Tw 14 0 0 14 177.8487 346.7292 Tm [(, Ale)21(x)10(ey\022)-23.2(A)-31(.\022)-23.3(Lik)11(utov)]TJ -0.069 Tc 0.069 Tw 8.162 0 0 8.162 283.7972 351.3912 Tm [(1,)-69(2)]TJ 0 Tc 0.023 Tw 14 0 0 14 295.1178 346.7292 Tm [(, Viktor\022)-23.3(V)62(.\022)-23.3(V)30(eselov)]TJ -0.069 Tc 0.069 Tw 8.162 0 0 8.162 397.888 351.3912 Tm [(1,)-69(2)]TJ 0 Tc 0 Tw 14 0 0 14 409.2086 346.7292 Tm (, )Tj -24.167 -1.143 Td [(Ale)21(x)10(ey\022)-23.2(A)-31(.\022)-23.3(P)10(onomar)31(enk)11(o)]TJ 8.162 0 0 8.162 206.8966 335.3912 Tm (1)Tj 0.023 Tw 14 0 0 14 211.5326 330.7292 Tm [(, Ale)21(x)10(ey\022)-23.2(S.\022)-23.3(T)40(sukanov)]TJ 0 Tw 8.162 0 0 8.162 327.911 335.3912 Tm (1)Tj 5.83 0 0 5.83 70.8661 316.39 Tm (1)Tj 0.023 Tw 10 0 0 10 74.1775 313.06 Tm [(R)20(y)21(zhikh National Medical Resear)31(ch Center of Colopr)20.1(octology \(Saly)21(ama Adily)21(a\022)-23.3(st., 2, Moscow)22(, 1)125(23)58(423, Russia\))]TJ 0 Tw ( )Tj 5.83 0 0 5.83 70.8661 304.39 Tm (2)Tj 0.023 Tw 10 0 0 10 74.1775 301.06 Tm [(Russian Medical Academ)21.1(y of Continuous Pr)20(ofessional Education \(Barrikadnay)21.1(a\022)-23.3(st., 2/1)69(, Moscow)22(, 1)125(2)23(5)23(99)35(3, )]TJ 0 Tw -0.331 -1.2 Td (Russia\))Tj /T1_0 1 Tf 0.024 Tw 9 0 0 9 119.0551 270.5561 Tm [(Juv)13(enile polyposis syndrome \(JPS\), a rare disease with an autosomal domin\ ant mode of inher)-37(itance, which is char)]TJ 0 Tw 44.743 0 Td (-)Tj 0.002 Tw -44.743 -1.111 Td [(acter)-36.9(ized with the p)46(resence of multiple polyps in v)16(ar)-37(ious par)-40(ts of the g)12(astrointestinal tract, mainly in the colon. The )]TJ 0.092 Tw T* [(detection of adenomatous polyps in patients with JPS, in addition to juv\ )13(enile ones, signif)-43(icantly com)16(plicates the )]TJ 0.026 Tw T* [(dif)-40(ferential diagnosis with familial adenomatous polyposis, in which it is \ necessar)-43(y to per)-34(for)-14(m a radical surg)11.9(er)-43(y)]TJ /Span<>> BDC ( )Tj EMC (\227 )Tj 0.04 Tw T* [(p)46(roctocolectom)11.1(y)32(. )0.5(Only in )0.5(40-60% of )0.5(cases, pathog)12.1(enic v)16(ar)-36.9(iants of )0.5(the SMAD4 )0.5(and BMP)66(R1A )0.5(g)12(enes can )0.5(be identif)-43(ied, )]TJ 0.015 Tw 0 -1.111 TD [(each of which is character)-36.9(ized with its own clinical manifestations. T)56(reatment op)13(tions for patients with JPS include )]TJ 0.044 Tw 0 -1.111 TD [(endoscopic and surgical; how)12(ev)13(er)61(, the decision-making algor)-36.9(ithm, as w)12(ell as the timing of postoperativ)13(e follow-up, )]TJ 0.118 Tw T* [(are )0.5(no)13(t ev)16(aluated )0.5(in )0.5(R)22(ussian )0.5(clinical guidelines. )0.6(The rare )0.5(occur)-15.9(rence )0.5(of this syndrome, dif)-40(f)-43(iculties in )0.5(endoscopic )]TJ 0.033 Tw T* [(diagnosis and mor)-18(phological v)13(er)-37(if)-43(ication, as w)12(ell as limitations in deter)-13.9(mining the molecular g)12(enetics cause of the )]TJ 0.023 Tw T* [(disease demonstrate the need for fur)-40(ther research.)]TJ /T1_2 1 Tf 0.01 Tc -0.01 Tw 8 0 0 8 70.9061 165.2868 Tm [(KEYW)22(ORDS:)]TJ /T1_0 1 Tf 0 Tc 0.023 Tw 4.948 0 Td [( juv)13(enile polyposis syndrome, hamar)-39.9(tomatous polyp, SMAD4, BMP)66.1(R1A)]TJ /T1_2 1 Tf 0.01 Tc 0.018 Tw -4.948 -1.909 Td [(C)19(ONFL)-33(ICT)5( OF)5( INTE)25(REST)62(:)]TJ /T1_0 1 Tf 0 Tc 0.023 Tw 9.871 0 Td [( authors declared no conf)-22(lict of interest)]TJ /T1_2 1 Tf 0.037 Tc 0.131 Tw -9.871 -2.617 Td [(F)3.2(O)-4.6(R)8.7( C)-17.5(I)-15.6(T)45.4(A)37.6(T)-24.5(I)-1.3(ON:)]TJ /T1_3 1 Tf 0.023 Tc 0.14 Tw 6.576 0 Td [( V)-21(l)-37.8(a)-26.6(s)-11.1(k)-3.7(o)]TJ /Span<>> BDC ( )Tj EMC [(T)52.5(.)-23.9(A)-23(.)-23.4(, L)-12.2(i)-6.6(k)-14.9(u)-16.3(t)-21.9(o)-10.3(v)]TJ /Span<>> BDC ( )Tj EMC [(A)-23(.)-23.9(A)-23(.)-23.5(, V)8.4(e)-22.8(s)-22.9(e)-18(l)-20.9(o)-10.3(v)]TJ /Span<>> BDC ( )Tj EMC [(V)39.7(.)40.6(V)39.7(.)-23.5(, P)-0.9(o)-9.2(n)-11.9(o)-9.2(m)-8.3(a)-10.2(r)-19.1(e)-11.5(n)-8.8(k)-3.7(o)]TJ /Span<>> BDC ( )Tj EMC [(A)-22.9(.)-23.9(A)-23(.)-23.5(, T)41.6(s)-8.8(u)-9.6(k)-24.2(a)-7.5(n)-12(o)-10.3(v)]TJ /Span<>> BDC ( )Tj EMC [(A)-23(.)-26.9(S)-9.6(. J)-7.2(u)-14.9(v)-18.7(e)-11.5(n)-14(i)-7.1(l)-23.7(e p)-22.3(o)-15.6(l)-8.3(y)-30.8(p)-22.3(o)-15.8(s)-26.1(i)-7.4(s s)-30.8(y)-27.5(n)-14.5(d)-10.4(r)-15.8(o)-9.2(m)-16.6(e \()39.3(r)-19.1(e)-15.8(v)-51.8(i)-11(e)-12.5(w)19.6(\))10.4(.)23( )]TJ /T1_0 1 Tf 0.033 Tc -0.033 Tw -6.581 -1.2 Td [(K)13.9(ol)3.6(op)2.4(r)3.1(o)3.4(k)-19.2(t)2.2(ol)3.6(o)-3.3(g)-13.2(i)6.7(a)5.8(.)]TJ /T1_3 1 Tf 0.013 Tc 0.034 Tw 7.019 0 Td [( 2)-18.9(0)-13.8(2)-1.2(4;2)-20.3(3)-4(\()27.7(1)34.3(\))4.6(:)10.9(1)2.5(4)-24.1(2\226)40.8(1)-9.1(5)28.2(1)-5.8(.)-10.3( \()-10.9(i)-13.2(n)-10.3( R)-16.5(u)-31.9(s)-32.2(s)-25.5(.)33.2(\).)-10.3( h)-27.2(t)-59.4(t)-39.4(p)-28.7(s)-18(:)-8(/)74.7(/)26.4(d)-21.1(o)-22.5(i)-10.2(.)-7.3(o)-21.8(r)-26.7(g)-32.8(/)1.2(1)4(0)-3.5(.)-15.6(3)-2.1(3)-25.8(8)-8.7(7)-5.4(8)-10(/)-2.1(2)-18.9(0)-0.7(7)-11.9(3)-23.3(-)31.2(7)0.7(5)-9.6(5)-18.9(6)-36.7(-2)-18.9(0)-13.8(2)-1.2(4)-38.5(-2)-20.3(3)-23.3(-)45.1(1)16.9(-)45.2(1)2.5(4)-24.1(2)2.1(-)45.1(1)-9.1(5)28.2(1)]TJ /T1_2 1 Tf 0.01 Tc 0.033 Tw -7.014 -2.617 Td [(\026\020\021\033\030)5( \020\036\017)5( \013\033\021\033\013\023\030\037\023:)]TJ /T1_0 1 Tf 0 Tc 0.038 Tw 10.606 0 Td [( \216\023\026\t\013\n )0.5(\220\026\024\022\002\021\026 \201\023\031\013\t\031\031\027\021\026, )0.5(\225\210\213\214 )0.5(\253\217\240\215\037 \013\n\023\n\033\032\n\013\024\n\023\n\202\025\025 \ \025\003\031\021\025 )0.5(\201.\217.)]TJ /Span<>> BDC ( )Tj EMC [(\212\020\204\025\004\273 )0.5(\240\025\021\016\030\032\026\027\026 \212\n\t\t\025\025, )0.5(\205\023.)]TJ /Span<>> BDC ( )Tj EMC (\207\026\023\002\003\026 )Tj 0.023 Tw -10.611 -1.2 Td (\201\030\025\023\002, \030.)Tj /Span<>> BDC ( )Tj EMC (2, \240\n\t\013\027\026, 123423, \212\n\t\t\025\002; e-mail: ta.vlasko@y\ andex.ru)Tj ET 1 0.68 0 0.12 k /GS0 gs q 1 0 0 1 70.8661 603.1533 cm 0 0 m 0 0 l 0 -11.339 l 42.52 -11.339 l 42.52 0 l h f Q BT 0 0 0 0 k /T1_2 1 Tf 0 Tw 9 0 0 9 76.0071 594.226 Tm (\021\033\r\035\f\033)Tj ET 1 0.68 0 0.12 k q 1 0 0 1 70.8661 279.0605 cm 0 0 m 0 0 l 0 -11.339 l 42.52 -11.339 l 42.52 0 l h f Q BT 0 0 0 0 k /T1_2 1 Tf 9 0 0 9 73.5728 270.1333 Tm (ABSTRACT)Tj ET q 0 0 566.929 793.701 re W n BT 1 0.68 0 0.12 k /T1_4 1 Tf 0.01 Tc 0.018 Tw 14 0 0 14 70.936 837.3533 Tm [(\004\210)42(\215\004\n)5( \b\006\r\207\n)43(\037)31(\r)-21(\013\n\233)]TJ /T1_1 1 Tf -0.01 Tw 0 -1.605 TD (REVIEW)Tj ET Q BT 1 0.68 0 0.12 k /T1_1 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\214)10(\211\036\033 \035\030\032\t\033)30(\b)42(\032)-21(\240\033\233)]TJ 57.136 0 Td (REVIEW)Tj -57.136 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 23, \023\0221)69(, 202)69(4)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 23, \023\0221)69(, 202)69(4)]TJ /T1_5 1 Tf 25 0 0 25 20.8528 56.0378 Tm (142)Tj ET q 0 g 0 G 0 j 0 J /Fm1 Do Q 0 0 0 0 k 396.85 725.67 59.155 11.338 re f /PlacedPDF /MC0 BDC q 397.481 736.808 m 397.242 736.808 397.049 736.616 397.049 736.376 c 397.049 736.376 l 397.049 726.285 l 397.049 726.045 397.242 725.853 397.481 725.853 c 397.481 725.853 l 455.382 725.853 l 455.62 725.853 455.815 726.045 455.815 726.285 c 455.815 726.285 l 455.815 736.376 l 455.815 736.616 455.62 736.808 455.382 736.808 c 455.382 736.808 l h W n q 0 g -0.0000005 -10.9560913 -10.9560913 0.0000005 426.4320445 736.8086309 cm BX /Sh0 sh EX Q Q q 396.85 725.67 59.155 11.337 re W n 0 0 0 0.84 k q 1 0 0 1 413.5634 732.4249 cm 0 0 m -0.025 0.1 -0.063 0.196 -0.112 0.287 c -0.157 0.374 -0.218 0.451 -0.292 0.515 c -0.37 0.582 -0.46 0.632 -0.558 0.664 c -0.669 0.701 -0.786 0.719 -0.903 0.717 c -1.076 0.722 -1.247 0.681 -1.4 0.6 c -1.536 0.526 -1.652 0.42 -1.74 0.292 c -1.83 0.158 -1.895 0.008 -1.934 -0.149 c -2.018 -0.48 -2.018 -0.827 -1.934 -1.158 c -1.896 -1.316 -1.83 -1.466 -1.74 -1.602 c -1.653 -1.731 -1.536 -1.837 -1.4 -1.912 c -1.247 -1.993 -1.076 -2.033 -0.903 -2.029 c -0.774 -2.032 -0.647 -2.006 -0.528 -1.955 c -0.427 -1.906 -0.337 -1.837 -0.263 -1.753 c -0.185 -1.665 -0.124 -1.563 -0.082 -1.453 c -0.034 -1.338 0 -1.218 0.019 -1.094 c 0.635 -1.094 l 0.624 -1.297 0.578 -1.497 0.497 -1.684 c 0.421 -1.857 0.312 -2.015 0.175 -2.146 c 0.039 -2.277 -0.123 -2.379 -0.3 -2.446 c -0.492 -2.519 -0.695 -2.555 -0.9 -2.552 c -1.15 -2.557 -1.397 -2.506 -1.625 -2.404 c -1.829 -2.307 -2.01 -2.169 -2.157 -1.997 c -2.308 -1.821 -2.423 -1.617 -2.497 -1.397 c -2.655 -0.924 -2.655 -0.412 -2.497 0.061 c -2.423 0.281 -2.307 0.485 -2.157 0.661 c -2.01 0.833 -1.829 0.973 -1.625 1.07 c -1.398 1.174 -1.15 1.226 -0.9 1.222 c -0.707 1.223 -0.515 1.196 -0.329 1.14 c -0.159 1.088 0.001 1.006 0.144 0.898 c 0.278 0.793 0.39 0.662 0.473 0.513 c 0.562 0.349 0.615 0.167 0.629 -0.019 c 0 -0.019 l 0 0 l f Q q 1 0 0 1 414.6923 733.5723 cm 0 0 m 0.584 0 l 0.584 -1.328 l 0.662 -1.204 0.771 -1.103 0.9 -1.033 c 1.046 -0.951 1.213 -0.91 1.381 -0.914 c 1.627 -0.9 1.869 -0.979 2.058 -1.137 c 2.234 -1.312 2.325 -1.556 2.305 -1.803 c 2.305 -3.596 l 1.716 -3.596 l 1.716 -1.976 l 1.724 -1.817 1.678 -1.66 1.585 -1.53 c 1.486 -1.43 1.347 -1.379 1.206 -1.392 c 1.114 -1.39 1.024 -1.408 0.94 -1.445 c 0.865 -1.479 0.798 -1.529 0.744 -1.591 c 0.687 -1.656 0.645 -1.73 0.616 -1.812 c 0.586 -1.896 0.571 -1.986 0.571 -2.077 c 0.571 -3.615 l 0 -3.615 l 0 0 l f Q q 1 0 0 1 418.0385 731.1235 cm 0 0 m 0 -0.099 0.014 -0.198 0.043 -0.292 c 0.069 -0.382 0.112 -0.466 0.17 -0.54 c 0.229 -0.611 0.304 -0.669 0.388 -0.709 c 0.486 -0.754 0.594 -0.776 0.702 -0.773 c 0.845 -0.78 0.987 -0.742 1.108 -0.664 c 1.217 -0.582 1.296 -0.468 1.336 -0.337 c 1.881 -0.337 l 1.827 -0.603 1.675 -0.838 1.456 -0.996 c 1.35 -1.073 1.231 -1.131 1.105 -1.169 c 0.971 -1.208 0.831 -1.229 0.691 -1.227 c 0.509 -1.227 0.328 -1.191 0.16 -1.121 c 0.007 -1.063 -0.13 -0.972 -0.244 -0.855 c -0.356 -0.73 -0.44 -0.583 -0.491 -0.422 c -0.548 -0.243 -0.576 -0.056 -0.574 0.133 c -0.575 0.313 -0.545 0.493 -0.486 0.664 c -0.426 0.826 -0.335 0.974 -0.22 1.102 c 0.004 1.375 0.338 1.534 0.691 1.535 c 0.883 1.539 1.072 1.495 1.243 1.408 c 1.402 1.326 1.541 1.209 1.649 1.067 c 1.759 0.922 1.838 0.757 1.883 0.582 c 1.932 0.396 1.945 0.203 1.92 0.013 c 0 0.013 l 0 0 l 1.342 0.377 m 1.335 0.468 1.315 0.557 1.283 0.643 c 1.253 0.724 1.209 0.798 1.153 0.863 c 1.097 0.922 1.03 0.97 0.957 1.004 c 0.874 1.043 0.783 1.063 0.691 1.062 c 0.6 1.062 0.509 1.044 0.425 1.009 c 0.345 0.976 0.273 0.926 0.213 0.863 c 0.153 0.799 0.105 0.724 0.072 0.643 c 0.037 0.559 0.017 0.468 0.014 0.377 c 1.355 0.377 l h f Q q 1 0 0 1 422.1581 731.7051 cm 0 0 m -0.012 0.144 -0.082 0.276 -0.194 0.366 c -0.31 0.452 -0.451 0.495 -0.595 0.489 c -0.675 0.488 -0.755 0.476 -0.831 0.452 c -0.918 0.424 -0.998 0.375 -1.062 0.311 c -1.142 0.229 -1.202 0.131 -1.24 0.024 c -1.29 -0.132 -1.312 -0.296 -1.304 -0.459 c -1.304 -0.569 -1.292 -0.677 -1.267 -0.784 c -1.244 -0.885 -1.202 -0.983 -1.145 -1.07 c -1.09 -1.154 -1.016 -1.224 -0.93 -1.275 c -0.833 -1.33 -0.722 -1.356 -0.611 -1.352 c -0.457 -1.357 -0.307 -1.301 -0.194 -1.195 c -0.078 -1.077 -0.005 -0.922 0.011 -0.757 c 0.587 -0.757 l 0.556 -1.055 0.419 -1.332 0.202 -1.538 c -0.022 -1.721 -0.306 -1.815 -0.595 -1.803 c -0.777 -1.806 -0.958 -1.771 -1.126 -1.7 c -1.293 -1.642 -1.445 -1.547 -1.57 -1.421 c -1.68 -1.297 -1.763 -1.151 -1.814 -0.993 c -1.87 -0.822 -1.898 -0.643 -1.896 -0.462 c -1.898 -0.276 -1.871 -0.091 -1.817 0.087 c -1.766 0.252 -1.682 0.405 -1.57 0.537 c -1.459 0.664 -1.323 0.766 -1.168 0.834 c -0.991 0.914 -0.798 0.955 -0.603 0.954 c -0.457 0.954 -0.311 0.935 -0.17 0.895 c -0.039 0.858 0.084 0.799 0.194 0.72 c 0.302 0.643 0.393 0.543 0.459 0.428 c 0.531 0.298 0.572 0.155 0.582 0.008 c 0 0.008 l 0 0 l f Q q 1 0 0 1 423.2177 733.5723 cm 0 0 m 0.577 0 l 0.577 -2.048 l 1.615 -0.985 l 2.322 -0.985 l 1.323 -1.944 l 2.417 -3.604 l 1.716 -3.604 l 0.919 -2.337 l 0.577 -2.669 l 0.577 -3.604 l 0 -3.604 l h f Q q 1 0 0 1 427.0585 732.5762 cm 0 0 m 0.436 0 l 0.436 0.218 l 0.429 0.352 0.448 0.486 0.488 0.614 c 0.521 0.705 0.577 0.786 0.651 0.85 c 0.717 0.905 0.795 0.943 0.879 0.961 c 0.966 0.979 1.056 0.988 1.145 0.988 c 1.28 0.993 1.416 0.981 1.548 0.954 c 1.548 0.505 l 1.509 0.516 1.469 0.523 1.429 0.528 c 1.379 0.532 1.33 0.532 1.28 0.528 c 1.209 0.53 1.14 0.511 1.081 0.473 c 1.019 0.419 0.987 0.337 0.999 0.255 c 0.999 -0.011 l 1.498 -0.011 l 1.498 -0.441 l 1.009 -0.441 l 1.009 -2.622 l 0.436 -2.622 l 0.436 -0.428 l 0.005 -0.428 l 0.005 0 l 0 0 l f Q q 1 0 0 1 430.1 729.8965 cm 0 0 m -0.191 -0.003 -0.381 0.032 -0.559 0.104 c -0.715 0.167 -0.856 0.264 -0.972 0.388 c -1.091 0.512 -1.181 0.659 -1.238 0.82 c -1.356 1.18 -1.356 1.567 -1.238 1.925 c -1.181 2.087 -1.091 2.234 -0.972 2.358 c -0.856 2.481 -0.715 2.578 -0.559 2.643 c -0.199 2.78 0.198 2.78 0.558 2.643 c 0.714 2.578 0.855 2.481 0.972 2.358 c 1.09 2.234 1.181 2.087 1.237 1.925 c 1.355 1.567 1.355 1.18 1.237 0.82 c 1.181 0.659 1.09 0.512 0.972 0.388 c 0.855 0.266 0.713 0.169 0.558 0.106 c 0.38 0.034 0.191 -0.002 0 0 c 0 0.454 m 0.115 0.451 0.23 0.479 0.332 0.534 c 0.424 0.586 0.502 0.659 0.562 0.746 c 0.624 0.836 0.669 0.936 0.695 1.041 c 0.752 1.26 0.752 1.491 0.695 1.71 c 0.669 1.816 0.625 1.916 0.562 2.005 c 0.502 2.091 0.423 2.163 0.332 2.215 c 0.123 2.323 -0.126 2.323 -0.335 2.215 c -0.427 2.163 -0.505 2.091 -0.566 2.005 c -0.628 1.916 -0.673 1.816 -0.699 1.71 c -0.756 1.491 -0.756 1.26 -0.699 1.041 c -0.672 0.936 -0.627 0.836 -0.566 0.746 c -0.506 0.659 -0.427 0.586 -0.335 0.534 c -0.232 0.478 -0.117 0.451 0 0.454 c f Q q 1 0 0 1 431.8979 732.5762 cm 0 0 m 0.531 0 l 0.531 -0.505 l 0.55 -0.43 0.583 -0.359 0.629 -0.297 c 0.681 -0.229 0.74 -0.167 0.807 -0.114 c 0.877 -0.059 0.956 -0.014 1.039 0.019 c 1.123 0.053 1.213 0.07 1.304 0.069 c 1.52 0.069 l 1.52 -0.486 l 1.395 -0.467 l 1.269 -0.467 l 1.178 -0.468 1.087 -0.488 1.004 -0.526 c 0.917 -0.565 0.839 -0.625 0.778 -0.699 c 0.716 -0.783 0.669 -0.878 0.643 -0.98 c 0.604 -1.104 0.584 -1.233 0.586 -1.362 c 0.586 -2.603 l 0.01 -2.603 l 0.01 0 l 0 0 l f Q q 1 0 0 1 437.3666 729.9683 cm 0 0 m -0.577 0 l -0.577 0.364 l -0.649 0.23 -0.759 0.121 -0.893 0.047 c -1.022 -0.029 -1.169 -0.07 -1.32 -0.072 c -1.595 -0.095 -1.866 0.002 -2.064 0.194 c -2.234 0.413 -2.316 0.687 -2.295 0.964 c -2.295 2.608 l -1.719 2.608 l -1.719 1.014 l -1.735 0.843 -1.689 0.67 -1.588 0.531 c -1.492 0.433 -1.357 0.382 -1.219 0.39 c -1.116 0.387 -1.012 0.406 -0.917 0.446 c -0.84 0.479 -0.772 0.531 -0.72 0.595 c -0.667 0.661 -0.63 0.738 -0.611 0.82 c -0.588 0.911 -0.577 1.003 -0.577 1.097 c -0.577 2.611 l 0 2.611 l 0 0 l f Q q 1 0 0 1 437.9877 732.5762 cm 0 0 m 0.545 0 l 0.545 -0.353 l 0.617 -0.209 0.736 -0.094 0.882 -0.026 c 1.03 0.04 1.19 0.073 1.352 0.072 c 1.535 0.075 1.717 0.038 1.883 -0.037 c 2.031 -0.106 2.161 -0.208 2.263 -0.334 c 2.366 -0.465 2.442 -0.615 2.489 -0.775 c 2.54 -0.948 2.566 -1.127 2.566 -1.307 c 2.566 -1.479 2.542 -1.651 2.497 -1.817 c 2.455 -1.973 2.385 -2.121 2.29 -2.252 c 2.099 -2.522 1.789 -2.682 1.458 -2.68 c 1.369 -2.681 1.28 -2.674 1.193 -2.659 c 1.11 -2.644 1.028 -2.618 0.951 -2.584 c 0.875 -2.552 0.802 -2.509 0.736 -2.457 c 0.671 -2.406 0.615 -2.343 0.571 -2.273 c 0.571 -3.575 l -0.005 -3.575 l -0.005 0 l 0 0 l 2.008 -1.307 m 2.008 -1.191 1.993 -1.076 1.963 -0.964 c 1.936 -0.859 1.89 -0.759 1.828 -0.669 c 1.768 -0.584 1.69 -0.514 1.599 -0.462 c 1.503 -0.409 1.395 -0.382 1.286 -0.385 c 1.072 -0.372 0.867 -0.467 0.738 -0.638 c 0.607 -0.836 0.543 -1.072 0.555 -1.31 c 0.554 -1.433 0.57 -1.557 0.603 -1.676 c 0.631 -1.781 0.68 -1.879 0.747 -1.965 c 0.809 -2.044 0.886 -2.109 0.975 -2.157 c 1.071 -2.206 1.178 -2.23 1.286 -2.229 c 1.401 -2.232 1.517 -2.205 1.618 -2.148 c 1.708 -2.096 1.785 -2.025 1.843 -1.939 c 1.903 -1.85 1.945 -1.751 1.968 -1.646 c 1.995 -1.535 2.008 -1.421 2.008 -1.307 c f Q q 1 0 0 1 443.5127 729.9683 cm 0 0 m -0.545 0 l -0.545 0.353 l -0.616 0.211 -0.734 0.099 -0.879 0.034 c -1.027 -0.031 -1.187 -0.065 -1.349 -0.064 c -1.532 -0.067 -1.714 -0.03 -1.88 0.045 c -2.028 0.113 -2.158 0.214 -2.26 0.34 c -2.364 0.47 -2.441 0.62 -2.486 0.781 c -2.538 0.958 -2.564 1.143 -2.563 1.328 c -2.568 1.536 -2.536 1.742 -2.468 1.938 c -2.41 2.097 -2.319 2.242 -2.202 2.364 c -2.101 2.471 -1.977 2.555 -1.838 2.608 c -1.705 2.659 -1.563 2.685 -1.421 2.685 c -1.338 2.685 -1.256 2.678 -1.174 2.664 c -1.091 2.648 -1.01 2.624 -0.932 2.589 c -0.855 2.556 -0.783 2.514 -0.717 2.462 c -0.652 2.411 -0.597 2.349 -0.553 2.279 c -0.553 3.606 l 0.024 3.606 l 0.024 0 l 0 0 l -2.008 1.277 m -2.009 1.166 -1.994 1.056 -1.965 0.948 c -1.939 0.845 -1.896 0.748 -1.835 0.661 c -1.777 0.578 -1.699 0.508 -1.61 0.459 c -1.404 0.355 -1.162 0.355 -0.956 0.459 c -0.866 0.512 -0.789 0.585 -0.73 0.671 c -0.671 0.762 -0.626 0.862 -0.6 0.966 c -0.572 1.076 -0.558 1.188 -0.558 1.301 c -0.543 1.542 -0.612 1.781 -0.751 1.979 c -0.88 2.14 -1.078 2.229 -1.283 2.22 c -1.402 2.224 -1.52 2.196 -1.623 2.138 c -1.714 2.083 -1.793 2.009 -1.852 1.92 c -1.911 1.828 -1.954 1.725 -1.977 1.617 c -1.999 1.505 -2.01 1.392 -2.008 1.277 c f Q q 1 0 0 1 446.3252 730.5499 cm 0 0 m -0.004 -0.052 0.005 -0.104 0.026 -0.151 c 0.052 -0.185 0.094 -0.202 0.136 -0.197 c 0.197 -0.197 l 0.223 -0.2 0.25 -0.2 0.276 -0.197 c 0.276 -0.595 l 0.199 -0.619 l 0.101 -0.64 l 0 -0.656 l -0.085 -0.656 l -0.187 -0.66 -0.288 -0.635 -0.377 -0.584 c -0.461 -0.528 -0.516 -0.437 -0.528 -0.337 c -0.648 -0.451 -0.792 -0.534 -0.951 -0.579 c -1.106 -0.628 -1.269 -0.654 -1.432 -0.656 c -1.546 -0.657 -1.659 -0.641 -1.769 -0.608 c -1.872 -0.579 -1.967 -0.531 -2.053 -0.468 c -2.136 -0.405 -2.203 -0.324 -2.25 -0.231 c -2.3 -0.127 -2.326 -0.012 -2.324 0.104 c -2.33 0.24 -2.299 0.375 -2.236 0.497 c -2.181 0.594 -2.101 0.675 -2.005 0.733 c -1.905 0.791 -1.795 0.833 -1.681 0.855 c -1.562 0.88 -1.442 0.899 -1.32 0.914 c -1.222 0.933 -1.123 0.947 -1.022 0.956 c -0.938 0.963 -0.855 0.977 -0.773 0.999 c -0.708 1.014 -0.649 1.046 -0.6 1.092 c -0.556 1.144 -0.533 1.211 -0.536 1.28 c -0.534 1.344 -0.553 1.408 -0.59 1.46 c -0.624 1.507 -0.668 1.544 -0.72 1.569 c -0.775 1.596 -0.834 1.613 -0.895 1.62 c -0.955 1.624 -1.016 1.624 -1.076 1.62 c -1.215 1.625 -1.354 1.591 -1.474 1.519 c -1.581 1.45 -1.647 1.333 -1.652 1.206 c -2.231 1.206 l -2.227 1.354 -2.185 1.498 -2.108 1.625 c -2.041 1.733 -1.951 1.824 -1.843 1.891 c -1.729 1.96 -1.603 2.007 -1.472 2.032 c -1.329 2.072 -1.183 2.098 -1.036 2.109 c -0.908 2.109 -0.781 2.096 -0.656 2.069 c -0.538 2.044 -0.425 2 -0.321 1.939 c -0.225 1.88 -0.143 1.8 -0.083 1.705 c -0.02 1.599 0.012 1.478 0.008 1.354 c 0.008 0.013 l 0 0 l -0.576 0.728 m -0.674 0.667 -0.785 0.631 -0.9 0.624 c -1.028 0.612 -1.155 0.594 -1.283 0.571 c -1.343 0.561 -1.402 0.547 -1.46 0.528 c -1.515 0.511 -1.566 0.485 -1.612 0.451 c -1.657 0.419 -1.692 0.376 -1.716 0.327 c -1.742 0.267 -1.755 0.203 -1.753 0.138 c -1.755 0.079 -1.735 0.021 -1.697 -0.024 c -1.661 -0.067 -1.615 -0.103 -1.564 -0.127 c -1.509 -0.154 -1.451 -0.171 -1.392 -0.181 c -1.335 -0.19 -1.278 -0.196 -1.222 -0.197 c -1.152 -0.196 -1.083 -0.188 -1.015 -0.173 c -0.94 -0.156 -0.87 -0.127 -0.805 -0.088 c -0.74 -0.048 -0.684 0.004 -0.64 0.066 c -0.594 0.134 -0.571 0.215 -0.574 0.297 c -0.574 0.725 l h f Q q 1 0 0 1 446.6836 732.5762 cm 0 0 m 0.434 0 l 0.434 0.784 l 0.996 0.784 l 0.996 0 l 1.527 0 l 1.527 -0.43 l 0.996 -0.43 l 0.996 -1.822 l 0.993 -1.874 0.993 -1.927 0.996 -1.979 c 1 -2.018 1.011 -2.056 1.031 -2.09 c 1.05 -2.122 1.079 -2.146 1.113 -2.159 c 1.162 -2.177 1.213 -2.185 1.265 -2.183 c 1.387 -2.183 l 1.428 -2.181 1.469 -2.175 1.509 -2.165 c 1.509 -2.608 l 1.323 -2.629 l 1.261 -2.633 1.199 -2.633 1.137 -2.629 c 1.013 -2.633 0.89 -2.619 0.771 -2.587 c 0.688 -2.564 0.613 -2.52 0.553 -2.459 c 0.499 -2.4 0.462 -2.328 0.446 -2.25 c 0.427 -2.155 0.416 -2.059 0.415 -1.963 c 0.415 -0.428 l -0.019 -0.428 l -0.019 0 l 0 0 l f Q q 1 0 0 1 449.0742 731.1235 cm 0 0 m 0 -0.099 0.014 -0.198 0.042 -0.292 c 0.068 -0.382 0.112 -0.466 0.17 -0.54 c 0.229 -0.611 0.303 -0.669 0.388 -0.709 c 0.486 -0.754 0.593 -0.776 0.701 -0.773 c 0.845 -0.78 0.987 -0.742 1.107 -0.664 c 1.216 -0.582 1.296 -0.468 1.336 -0.337 c 1.88 -0.337 l 1.827 -0.603 1.674 -0.838 1.456 -0.996 c 1.349 -1.073 1.231 -1.131 1.105 -1.169 c 0.973 -1.208 0.836 -1.228 0.699 -1.227 c 0.512 -1.23 0.327 -1.196 0.154 -1.126 c 0.003 -1.066 -0.133 -0.973 -0.244 -0.855 c -0.356 -0.73 -0.44 -0.583 -0.491 -0.422 c -0.548 -0.243 -0.576 -0.056 -0.574 0.133 c -0.575 0.313 -0.546 0.493 -0.486 0.664 c -0.426 0.826 -0.336 0.974 -0.221 1.102 c 0.002 1.374 0.334 1.532 0.685 1.535 c 0.877 1.539 1.067 1.495 1.238 1.408 c 1.396 1.326 1.535 1.209 1.644 1.067 c 1.753 0.922 1.833 0.757 1.878 0.582 c 1.927 0.396 1.939 0.203 1.915 0.013 c -0.002 0.013 l 0 0 l 1.341 0.377 m 1.335 0.468 1.315 0.557 1.283 0.643 c 1.253 0.724 1.209 0.798 1.153 0.863 c 1.096 0.926 1.027 0.978 0.951 1.014 c 0.868 1.054 0.777 1.074 0.685 1.073 c 0.594 1.073 0.504 1.055 0.419 1.02 c 0.339 0.986 0.267 0.937 0.207 0.874 c 0.147 0.81 0.099 0.735 0.066 0.653 c 0.031 0.569 0.011 0.479 0.008 0.388 c 1.349 0.388 l h f Q q 1 0 0 1 451.8657 730.7994 cm 0 0 m 0.002 -0.142 0.073 -0.274 0.191 -0.353 c 0.312 -0.423 0.45 -0.458 0.59 -0.454 c 0.651 -0.458 0.711 -0.458 0.773 -0.454 c 0.839 -0.447 0.904 -0.43 0.967 -0.406 c 1.024 -0.385 1.075 -0.349 1.116 -0.303 c 1.155 -0.252 1.174 -0.189 1.168 -0.125 c 1.166 -0.057 1.138 0.008 1.089 0.056 c 1.033 0.107 0.967 0.146 0.895 0.17 c 0.809 0.201 0.72 0.226 0.629 0.245 c 0.329 0.33 l 0.224 0.352 0.121 0.38 0.019 0.415 c -0.076 0.446 -0.166 0.491 -0.247 0.55 c -0.327 0.608 -0.391 0.683 -0.436 0.771 c -0.486 0.873 -0.511 0.986 -0.507 1.1 c -0.512 1.226 -0.475 1.351 -0.404 1.456 c -0.333 1.551 -0.243 1.63 -0.138 1.687 c -0.028 1.747 0.092 1.788 0.215 1.809 c 0.337 1.832 0.462 1.843 0.587 1.843 c 0.716 1.844 0.845 1.83 0.972 1.801 c 1.09 1.774 1.202 1.727 1.304 1.663 c 1.404 1.598 1.488 1.513 1.551 1.413 c 1.621 1.3 1.663 1.173 1.676 1.041 c 1.076 1.041 l 1.059 1.155 0.989 1.253 0.887 1.307 c 0.78 1.355 0.665 1.38 0.547 1.378 c 0.5 1.381 0.452 1.381 0.403 1.378 c 0.35 1.373 0.298 1.36 0.247 1.341 c 0.2 1.325 0.157 1.297 0.122 1.262 c 0.087 1.224 0.069 1.174 0.071 1.124 c 0.069 1.058 0.096 0.995 0.146 0.951 c 0.202 0.903 0.267 0.866 0.337 0.842 c 0.424 0.811 0.512 0.786 0.603 0.768 c 0.917 0.701 l 1.021 0.678 1.124 0.65 1.224 0.616 c 1.319 0.584 1.409 0.539 1.49 0.481 c 1.662 0.359 1.762 0.16 1.755 -0.05 c 1.76 -0.189 1.723 -0.326 1.649 -0.443 c 1.582 -0.551 1.491 -0.642 1.384 -0.709 c 1.267 -0.778 1.14 -0.827 1.007 -0.855 c 0.873 -0.885 0.735 -0.9 0.598 -0.9 c 0.443 -0.902 0.29 -0.883 0.141 -0.845 c 0.01 -0.812 -0.114 -0.753 -0.223 -0.674 c -0.324 -0.601 -0.407 -0.504 -0.465 -0.393 c -0.527 -0.269 -0.559 -0.131 -0.558 0.008 c 0.019 0.008 l 0 0 l f Q 0.146 0.941 0.992 0.044 k q 1 0 0 1 401.2527 729.3892 cm 0 0 m 3.612 2.406 l 3.612 5.296 l 0 5.296 l h f Q 0 0.889 0.676 0 k q 1 0 0 1 404.865 729.3892 cm 0 0 m -3.612 2.406 l -3.612 5.296 l 0 5.296 l h f Q 0.694 0.076 0.209 0 k q 1 0 0 1 403.0589 735.3145 cm 0 0 m -2.2 0 -3.984 -1.784 -3.984 -3.984 c -3.984 -6.184 -2.2 -7.968 0 -7.968 c 2.2 -7.968 3.984 -6.184 3.984 -3.984 c 3.984 -1.784 2.2 0 0 0 c 0 -6.993 m -1.662 -6.993 -3.009 -5.646 -3.009 -3.984 c -3.009 -2.322 -1.662 -0.975 0 -0.975 c 1.662 -0.975 3.009 -2.322 3.009 -3.984 c 3.009 -5.646 1.662 -6.993 0 -6.993 c f Q 0 0.235 0.86 0 k q 1 0 0 1 405.2601 729.2803 cm 0 0 m -1.118 -1.208 -3.015 -1.281 -4.237 -0.159 c -5.159 0.688 -5.459 2.005 -4.999 3.156 c -5.833 3.687 l -6.736 1.681 -5.843 -0.679 -3.836 -1.582 c -2.218 -2.311 -0.312 -1.881 0.836 -0.528 c 0 0 l f Q 0 0 0 0.6 k q 1 0 0 1 397.4813 736.8087 cm 0 0 m -0.238 0 -0.432 -0.193 -0.432 -0.432 c -0.432 -10.524 l -0.432 -10.763 -0.238 -10.956 0 -10.956 c 57.901 -10.956 l 58.139 -10.956 58.333 -10.763 58.333 -10.524 c 58.333 -0.432 l 58.333 -0.193 58.139 0 57.901 0 c h 57.901 -11.155 m 0 -11.155 l -0.348 -11.155 -0.631 -10.872 -0.631 -10.524 c -0.631 -0.432 l -0.631 -0.084 -0.348 0.199 0 0.199 c 57.901 0.199 l 58.249 0.199 58.532 -0.084 58.532 -0.432 c 58.532 -10.524 l 58.532 -10.872 58.249 -11.155 57.901 -11.155 c f Q EMC Q endstream endobj 918 0 obj <> endobj 927 0 obj <>stream Adobe Illustrator CS6 (Windows) 2021-04-12T11:45:36+05:00 2021-06-02T10:28:09+05:00 2021-06-02T10:28:09+05:00 1 False False 20.868494 3.999928 Millimeters Cyan Magenta Yellow Black Default Swatch Group 0 C=0 M=24 Y=86 K=0 PROCESS 100.000000 CMYK 0.000000 23.504999 86.022697 0.000000 C=69 M=8 Y=21 K=0 PROCESS 100.000000 CMYK 69.369003 7.635600 20.892700 0.000000 C=0 M=89 Y=68 K=0 PROCESS 100.000000 CMYK 0.000000 88.946404 67.623398 0.000000 C=15 M=94 Y=99 K=4 PROCESS 100.000000 CMYK 14.578501 94.070297 99.160698 4.416000 C=0 M=0 Y=0 K=84 PROCESS 100.000000 CMYK 0.000000 0.000000 0.000000 84.000000 C=0 M=0 Y=0 K=35 PROCESS 100.000000 CMYK 0.000000 0.000000 0.000000 35.000000 C=0 M=0 Y=0 K=60 PROCESS 100.000000 CMYK 0.000000 0.000000 0.000000 60.000004 Document application/pdf proof:pdf xmp.did:804244B35A9BEB118A6FC3C256996E2F uuid:08e30110-bdb7-4606-97ca-63fb62cbcecc uuid:21079f76-f6d7-4329-b725-f2fb35af5114 uuid:722f8893-0b3c-4402-87fb-c713f1fa0e26 uuid:21079f76-f6d7-4329-b725-f2fb35af5114 uuid:21079f76-f6d7-4329-b725-f2fb35af5114 proof:pdf saved xmp.iid:804244B35A9BEB118A6FC3C256996E2F 2021-04-12T11:45:42+05:00 Adobe Illustrator CS6 (Windows) / endstream endobj 917 0 obj <> endobj 928 0 obj <> endobj 929 0 obj <> endobj 930 0 obj <>stream H\n0~ C`Q$`}GS,o_͎"5`LSoG\ron߇ksws:wo5-M{n7\l>>|xNba?oagoCsf~f~x?)ri|r/};~?^g)%Lsm?6y8voy(,vg9](}v]xZT6Ў:PP'診 ЉfEk֜S@szq] zq;j[9BOXǒ'~0X{iY/jX;bcjh;O~>stream HdT TSW3|BBȓv,BT5|"GƱ0(!bQZ0C+APVkD,kY2yZsK{9s眻縷 QFGO"9?BlvѤ(c}"w-DE{ yx=>"@y GDClBe Yz mGP ڏQdC]F}tW5%(oʏP`j25R"*ʢr) ULm6SQT-UGݤVB%݈ c>bt TX L09E9MFT90V/`#fޱ@/:F{@FQPf 0Ce:"CP!R* hDN9"D3y#”sA9̑6kLt٘m*LŜi䦛k4髍椢Ƃ MbplvN} d('E! 9LDF4*G;<!.N1Gh:EMP:-p"!2^ LoL(´H%i<9eVE|>u.u7WR2:*H㤽ҧ=L2P([Cp%%s|q@gg (dx&u0hCNZ6h(H;Ka#8LlSc\8x5&%IN,OuO--..5-~V[G0iV{*G/V>Nz*[:/KY\OhQcmgG^L|`qI-Z2/0+7d9;̜e_iCʶF][[_mB@pϢoݠz!uOXs;cR Vm_k޹8 8Cp6Mn=./s~<'$ e{u:yρRl$L]4K_.ZnXU+H2WsulۓmIIK㤷%?m GP[ ny!1R6>iiᶗyOI Rd/x_k"魰up'OTvW5ܕqL]\rg|=9KWfua,vYs7ez./>7n[W^Z˳ U>Zܪ.Z&2Ҫʧ+e?Q2Vc3m U]^$q;Aw(U`CM: paIF|r 'ȎjfK~{œ@ђ{݆l*[ەg3cUQ1Fuz|dYH(%o,0Z3H|Fr'yh3:~"Y(|"> #!Bx}tP&L.b'osm_vaw/Z-\ĵ{wYX &n' d:C嚑4R{>|:wd \IiGJmO$712!I ^3 7[{}KRK"l+lw6bx7Lb1Q$S ωwK'H 􀽠xfxO֒`z57nhgj {idX^{o, >Bh(aѨ /A@pYEԈ>0C5V+B>PtdMm͌UF=L55ٹ3|{;oYDlN L֑I#ZH\x`ӦW +B=&WFMwmyp:|E|~ ",]ט=!cIܔ̇l::.{ k[~2=Y4+JvqN ͫ+K+ʧ'KFBAr`}?p\J "y2Swu1ZQݺݴTfKfU!@۸lu@M¬9T߿Ig'ĸp C䱭ۏ9m?}L51W^,}D8dX$u)"aAiaD ]50Le.i ݋߿&trx{]'H> mʼ4{_`BؐBF<P6i&YRҐ'-NX".oCfۇ*p4x>D> D ?@$ܠC-DkXEnPli4а~MHq y ȏ4.a͌4m颤2UWN|r*$Not 9`gQ:H.Gؘ#kKS3'c|]N =}b㗸b^htyw@pv_u/9MW]mx4C m%pe A,}_L[ujᄡ/6SGp$ bZV7 qEѼj}T~SXg Ad=JiQ0dKQ -- -- QQQ85 !fz7mgۂFr `e~K~o|EfdIIi(Phe{\) ףbIo*Jʎ59izHVQj[]Ŵ4%6 uk4byV?A˵ z=l ً׈c`%z7~?ȨDsGot]0B~tO`Eⶫٵ%cFF$iE@"kHP_xyxPl/gRoMv]Fl̯YzQ4K )Њl8)Y} }疜㿤֐Cu{dMZl$[F0&eUSĩmX^",Y@%xw7fz1 $7%W]Zĕ֔$ ro?ن&( K&rkunlP710WE -}n﨩Elkj9Lj攭BfFʮT>5HIRSWAz[oy ,*IEq4>B>5789H@hR@]!iK I &(eU@grOX0wRֱCp*bCm hNe鐇UuIrڹ^z#~7[b߸KId3ji-Z_▨jVu$1wP`RqLj|46OQ&gڛ_9l2A˩̭眯z$A4~ATC7]ּnJMxoDQ5‚^2J >Ь$Sa`W(rp>JR2CwZWBhP)6ȐD,.عK߽cag67<6y7C捈g+#$?>o *Mb;3jKG5iKLM1.*/'M{Eq< CfXV7J(1F] ܢr r ȥ#5 #g@EADZ@7Fݸ}ʯ@?w|?_8;ŵ)f銄l%FleoXq(XT`k$>7ނ\γ6]M8]k"WXSl &djbmxϸVTsg{r=l®7\^;oXO7F7 J<:ut _LdwbX<Tthch(G$+c~ZY|X^^WU? C0#iE*4,\;,_VТ5 &)$Z2ÆT|2j-$."ym!rxM W'P[5>~,^&^+&1^RJSt8^\R-N/'@ z$hE;Nn<_AȷDMt'q>L2k}"-M`n9]赺0Q 1&oa.{ Yk{9׹061NMKȏyl>_zt?dnO$YSpOiĚx[pQ1'pĪ~!? cZ1:cPOcS\Hcs˱{*Cq1wگ44e42Jt@) #EBVUT]̴SSqi87"pɣqDv_zRjqP&7G|@:bn 9٣Z4P0ؑc3Y΁o@x vgWVeZǦ)Si\z\x-n4\iڱd-O]TºvN3=\EiUm]?b ㏚h Uu-Q5q%lyonꞼ;I@~/he4bO) ~*0CZ8N<9+| Va>kE!]D,L^'iݛgRKȪP݈7me!A~LK3ems`^cZJT'9. Nb>߼~NcmJ>'B2+i^du[-[h{[B|/qdȺ .41M-o(xkøG`j"F $0U_*ޚJGQJCLd(!2ҝV5vяL,yn櫄r$]Fs/D0  ==G$C4s;g" "eʃ*]:'}aȦfH?[IwXAHNLJ[Ą@߃9IիW 7R8^o0afsE z_q=6m[Z$kl?>N(}qֳL{`LaP9?#G_p1QnIMe{d]?,XF7<5d eI XmA .R):›,tCC^J+*cPxs_틈ItTlLKpI-Yr`v d^b;K/ 7t־=Y;$qJp|Im][^}aS̪G5nBb_R՞};>:{O՜R j9آ'^r93bۊNia8l_c8D,_6X?R=DO BABB''a&[Q+!NU›qEG2h~F7(S' Œ~d.evXϹ㫔apB@ENosv-#O~{'`q~0Kld%_Y<0cM `FfHTrAlc垁9&f|~!tt-*S,7QB q{]K iD/)VzR"{ȮGΊ8,P]g UU\S@䵀L{蘨4wH$kd:?^y'ø`<(T +1Vm&M73@@m}mr\~ԗ;H̗|g9rޡ[ EJjfXr*<,2]?=URVj/h fj<7U-_Y(1P#7R0+3W,f%PQ+вl,[ @)g6ׁ -#3[:2ʌ*%]VJ}J$M9/W3O>@[sX{WƓ Jl>m99NRvB6-YְwEm}ӾqTwl*{jw{[ 7ߣ6k ¶gâr+Hz춆򳿳NP&WR_!VXY! [7sV~?ΊhZlD8!fo!@-V΄QPg;|oʕ WܶCtѾr}&EI+\qd{02PDXbudCn{0JVZPh&R\|#Xo&*3|BGߕfz[NWg?twψ``Ëfpd `=6ʔ35wtvΕ y8yp}qFcQg ! endstream endobj 926 0 obj <>/Border[0 0 0]/H/N/Rect[394.85 739.008 458.005 723.67]/Subtype/Link/Type/Annot>> endobj 932 0 obj <> endobj 913 0 obj [933 0 R 934 0 R 935 0 R 936 0 R 937 0 R 938 0 R 939 0 R 940 0 R 941 0 R 942 0 R 943 0 R 944 0 R 945 0 R 946 0 R 947 0 R 948 0 R] endobj 914 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\032)30(\215\f\215\007\205\002\001\025\016 \215\201\r\025\016\001\220\016 \006\220\ \202)10.1(\024\025\r\220\201\001\025\203 \n\220\n\220: )]TJ 0 -1 TD [(\025\221\220\006\013\001\220\016 \n)-10(\007\220\001\220\017\016\006\n)10(\025\202)10(\025 \006)-10(\007\215\017\013\205)]TJ 39.376 1 Td [(T)30(ubular duplication of th)11(e sigmoid colon: clinical case)]TJ /T1_1 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 42.5896 724.8299 Tm [(\r\031\024\034\033)48(\026)45(\024)-10(\223\033)48(\026)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf 0 Tc 0.081 Tw 8 0 0 8 42.5197 711.9952 Tm (1.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (\202\004\022\026\f\024\r)Tj /Span<>> BDC ( )Tj EMC (\221.\222. \202\027\024\n\026\035\017\017 \030\026\r\017\021\017\016 \017\ )Tj /Span<>> BDC ( )Tj EMC (\023\024\035\024\032\036\027\017\016 \021\024\035\f\021\024\005 \022\017\ \001\022\017. )Tj 0.024 Tw -1.296 -1.25 Td (\025\035\017\027\017\022\026, \007\017\026\020\027\024\f\021\017\022\026\ , \035\036\004\036\027\017\036. \202\r\021\024\030\036\235\036\030\026 \007\ \017\f\f\036\030\021\026\006\017\017 \027\026)Tj /Span<>> BDC ( )Tj EMC (\f\024\017\f)Tj 0 Tw (-)Tj 0.141 Tw 0 -1.25 TD (\022\026\027\017\036 \031\004\036\027\024\005 \f\021\036\023\036\027\017\ \007\024\022\021\024\030\026 \n\036\007\017\006\017\027\f\022\017\b \027\ \026\031\022. \204\024\f\022\r\026, 2003. )Tj 0 Tw T* [(ht)-30(tps://www.el)-30.9(ibr)-32.9(ar)-24(y.r)-22(u/i)-23.9(tem.asp?Id=30174982)]TJ 0.01 Tc 0.382 Tw T* (2.)Tj /Span<>> BDC ( )Tj EMC 1.327 0 Td (\202\001\022\030\026\235\021)Tj /Span<>> BDC ( )Tj EMC (\025.\211., \216\024\035\007\036\030)Tj /Span<>> BDC ( )Tj EMC [(\230.\204. \212\036\021\f\022\026\016 \b\017\030\031\030\020\017\016. \221\ \215\002.: \222\223\215)10( )]TJ 0 Tc 0.023 Tw -1.327 -1.25 Td (\253\216\026\030\007\235\024\030\007\273, 1996;2:392.)Tj 0.337 Tw T* (3.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(S)15(tr)-37(inger)]TJ /Span<>> BDC ( )Tj EMC 3.801 0 Td [(MD. )0.5(Dupl)-31(ica)15(t)-32(ions )0.5(of )0.5(t)-12.9(he Al)-30.9(iment)15(ar)-24(y )0.5(T)50(r)-33(a)-17(c)-15.9(t. In: )0.6(P)20(ur)-37(i, )]TJ 0.008 Tc 0.35 Tw -5.097 -1.25 Td [(P. \(eds\) P)29.8(edia)14.7(tr)-37.2(ic Sur)-32.2(ger)-24.2(y. Sp)24.7(r)-37.2(inger, Ber)-30.3(l)-31.2(in, Heidelber)-32.3(g. 2020.)8( )]TJ 0 Tc 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1007/978-3-662-43588-5_68)Tj 0 0 0 1 k /GS1 gs 0.02 Tc 0.727 Tw -1.847 -1.25 Td (4.)Tj /Span<>> BDC ( )Tj EMC 1.356 0 Td [(Sax)12(ena)]TJ /Span<>> BDC ( )Tj EMC 3.907 0 Td [(AK. Gastr)-32(ointest)-32.1(inal )0.5(Dupl)-31.1(ica)14.9(t)-32.1(ions )0.5(T)49.9(r)-24.1(ea)15(tment &)20( )]TJ 0 Tc 0.32 Tw -5.263 -1.25 Td [(Mana)-17(gement. In Medscape; A)15.1(v)-15(ail)-16(able a)15(t ht)-30(tps://emedic)-23.9(ine.med)]TJ 0 Tw (-)Tj 0.023 Tw T* [(scape.com/ar)-21.9(t)-32(icle/936799-tr)-23.9(ea)15(tment. 2020 A)-24.9(ccessed 12 N)-14(ov, 2023.)]TJ 0.032 Tc 0.79 Tw T* (5.)Tj /Span<>> BDC ( )Tj EMC 1.392 0 Td (\217\026\031\n\024\r\f\022\017\005)Tj /Span<>> BDC ( )Tj EMC (\202.\236., \212\030\024\027\024\r)Tj /Span<>> BDC ( )Tj EMC [(\202.\205. \212\036\021\f\022\026\016 \b\017\030\031\030\020\017\016.)32( )]TJ 0.01 Tc 0.023 Tw -1.392 -1.25 Td (\203\026\006\017\024\027\026\035\034\027\024\036 \030\031\022\024\r\024\007\ \f\021\r\024. \204.: \206\224\210\230\202\217-\204\036\007\017\026. 2021\ ; 1078 \f.)Tj 0.002 Tc 0.349 Tw T* (6.)Tj /Span<>> BDC ( )Tj EMC 1.301 0 Td [(Cl)-30.5(inica)0.5(l ch)0.5(ar)-32.6(a)-16.6(c)-15.5(ter)-36.5(ist)-31.6(ic)0.5(s of g)0.5(astr)-31.6(o)0.5(inte)0.5(st)-31.6(in)0.5(al t)0.5(r)-32.6(a)-16.6(c)-15.6(t)0.5( du)0.5(pl)-30.6(ic)0.5(a)15.4(t)-31.6(io)0.5(ns)2( )]TJ 0 Tc 0.243 Tw -1.301 -1.25 Td [(in childr)-24(en: A single-inst)-31.9(i)-24(tut)-32(ion ser)-37(ies r)-24(ev)-16(iew. L)-32(i Xiang, Jiaming )]TJ 0.094 Tw T* [(L)-32(an, Bail)-31(in Chen, P)-24(ing L)-32(i, Chunbao Guo. )]TJ /T1_3 1 Tf (Medicine \(Baltimore\).)Tj /T1_2 1 Tf ( 2019 )Tj 0.236 Tw 29.055 20 Td [(N)-14(ov;98\(44\):e17682. P)20(ubl)-30.9(ished onl)-31(ine 2019 N)-14(ov 1. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1097/)Tj T* (MD.0000000000017682)Tj 0 0 0 1 k /GS1 gs 0.252 Tw T* (7.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Ok)-17(amo)17(t)17(o)]TJ /Span<>> BDC ( )Tj EMC [(T, T)40(ak)-17(amiza)10(w)-12(a)]TJ /Span<>> BDC ( )Tj EMC [(S, Y)40(okoi)]TJ /Span<>> BDC ( )Tj EMC [(A, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Com)10(ple)-12(tel)35.1(y isol)-15.9(a)15(ted )]TJ 0.191 Tw -1.296 -1.25 Td [(al)-31(iment)15.1(ar)-24(y tr)-33(a)-17(c)-16(t dupl)-31(ica)15.1(t)-32(ion in a neona)15(te. )]TJ /T1_3 1 Tf [(P)15(ediatr Surg Int)]TJ /T1_2 1 Tf (. 2008 )Tj 0.023 Tw T* [(O)-16(c)-16(t;24\(10\):1145\2267. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1007/s00383-008-2220-y)Tj 0 0 0 1 k /GS1 gs 0.222 Tw T* (8.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Mar)-22(t)-32(ini)]TJ /Span<>> BDC ( )Tj EMC [(C, P)40(a)-17(gano)]TJ /Span<>> BDC ( )Tj EMC [(P, P)30(er)-24(r)-32(one)]TJ /Span<>> BDC ( )Tj EMC [(G, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Intest)-32(inal dupl)-31(ica)15.1(t)-32(ions: )]TJ 0.116 Tw -1.296 -1.25 Td [(inc)-24(ident)15.1(all)35(y ileum dupl)-30.9(ica)15(t)-32(ion cy)-12.9(st in young female. )]TJ /T1_3 1 Tf [(BJR Case R)21(ep)]TJ /T1_2 1 Tf 0 Tw (. )Tj 0.023 Tw T* [(2019;5:20180077. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw [(10.1259/bjr)-32(cr.20180077)]TJ 0 0 0 1 k /GS1 gs 0.005 Tc 0.35 Tw T* (9.)Tj /Span<>> BDC ( )Tj EMC 1.311 0 Td [(McNut)-29.9(t)]TJ /Span<>> BDC ( )Tj EMC 3.562 0 Td [(R, )0.5(S)-23.9(chmi)-24(t)-29.9(t)]TJ /Span<>> BDC ( )Tj EMC 5.133 0 Td [(D, )0.5(S)-23.9(chul)56(te)]TJ /Span<>> BDC ( )Tj EMC 4.944 0 Td [(W. )0.5(Giant )0.6(col)30(onic )0.6(di)-15.9(ver)-22(t)-31.9(icul)-16(a-)]TJ 0 Tc 0.2 Tw -14.949 -1.25 Td [(t)-13(hr)-23.9(ee dist)-32(inc)-16(t ent)-32(i)-24(t)-32(ies. R)13(epor)-21.9(t of a case. )]TJ /T1_3 1 Tf [(Dis Colon R)21(ectum.)]TJ /T1_2 1 Tf ( 1988 )Tj 0.023 Tw T* [(A)10(ug;31\(8\):624\2268. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1007/BF02556799)Tj 0 0 0 1 k /GS1 gs 0.019 Tc 0.696 Tw T* (10.)Tj /Span<>> BDC ( )Tj EMC 1.873 0 Td [(Gonz\341lez-V)24.7(al)29.8(ver)-24.2(de)]TJ /Span<>> BDC ( )Tj EMC [(FM, Madr)-37.2(id-Ba\361os B, Ruiz-Mar\355n)]TJ /Span<>> BDC ( )Tj EMC [(M.)19( )]TJ 0.008 Tc 0.35 Tw -1.873 -1.25 Td [(Giant Di)-16.4(ver)-22.4(t)-32.4(icul)34.7(um of t)-13.4(he S)-16.4(igmoid Col)29.6(on. )]TJ /T1_3 1 Tf (J Gastrointest Surg)Tj /T1_2 1 Tf 0 Tc 0 Tw (. )Tj 0.023 Tw T* [(2021;25:1347\2261349. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1007/s11605-020-04841-x)Tj 0 0 0 1 k /GS1 gs 0.228 Tw T* (11.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Cho)-16(ong)]TJ /Span<>> BDC ( )Tj EMC [(CK, F)10(r)-36.9(izelle)]TJ /Span<>> BDC ( )Tj EMC [(F)24(A. Giant col)30(onic di)-16(ver)-22(t)-31.9(icul)35(um. )]TJ /T1_3 1 Tf (Dis Colon )Tj 0 Tw -1.796 -1.25 Td [(R)21(ectum.)]TJ /T1_2 1 Tf 0.023 Tw [( 1998;41:1178\2261185. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1007/BF02239441)Tj /T1_1 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 42.5896 517.8039 Tm (REFERENCES)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf 0 Tc 0.054 Tw 8 0 0 8 42.5197 504.9692 Tm (1.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(A)-25(chk)-17(asov)]TJ /Span<>> BDC ( )Tj EMC 4.081 0 Td [(S.I. )0.6(Anomal)-31(ies )0.6(of )0.5(t)-13(he )0.6(devel)30(opment )0.6(and )0.5(posi)-23.9(t)-32(ion )0.5(of )0.6(t)-13(he )]TJ 0.117 Tw -5.377 -1.25 Td [(col)30(on. Cl)-31(inic, dia)-17(gnosis, tr)-24(ea)15(tment. A)-14(bstr)-32.9(a)-17(c)-16(t of t)-12.9(he disser)-21.9(t)15(a)15(t)-32(ion for )]TJ 0.044 Tw T* [(t)-13(he degr)-24(ee of Do)-15.9(c)-16(t)17(or of Medical S)-24(c)-24(iences. M)-24(osco)-14(w, 2003. \(in Russ.\). )]TJ 0 Tw T* [(ht)-30(tps://www.el)-30.9(ibr)-32.9(ar)-24(y.r)-22(u/i)-23.9(tem.asp?Id=30174982)]TJ 0.012 Tw T* (2.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Ashcr)-33(af)-27.9(t)]TJ /Span<>> BDC ( )Tj EMC (K.W., Holder)Tj /Span<>> BDC ( )Tj EMC [(T.M. P)30(edia)15(tr)-36.9(ic sur)-32(ger)-23.9(y. S)15(t. P)30(e)-12(ter)-10(sbur)-31.9(g: ICHP )]TJ 0.023 Tw -1.296 -1.25 Td [(\231Har)-24(dfor)-23.9(d\232. 1996;2:392. \(in Russ.\).)]TJ 0.337 Tw T* (3.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(S)15(tr)-37(inger)]TJ /Span<>> BDC ( )Tj EMC 3.801 0 Td [(MD. )0.5(Dupl)-31(ica)15(t)-32(ions )0.5(of )0.5(t)-12.9(he Al)-30.9(iment)15(ar)-24(y )0.5(T)50(r)-33(a)-17(c)-15.9(t. In: )0.6(P)20(ur)-37(i, )]TJ 0.008 Tc 0.35 Tw -5.097 -1.25 Td [(P. \(eds\) P)29.8(edia)14.7(tr)-37.2(ic Sur)-32.2(ger)-24.2(y. Sp)24.7(r)-37.2(inger, Ber)-30.3(l)-31.2(in, Heidelber)-32.3(g. 2020.)8( )]TJ 0 Tc 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1007/978-3-662-43588-5_68)Tj 0 0 0 1 k /GS1 gs 0.02 Tc 0.727 Tw -1.847 -1.25 Td (4.)Tj /Span<>> BDC ( )Tj EMC 1.356 0 Td [(Sax)12(ena)]TJ /Span<>> BDC ( )Tj EMC 3.907 0 Td [(AK. Gastr)-32(ointest)-32.1(inal )0.5(Dupl)-31.1(ica)14.9(t)-32.1(ions )0.5(T)49.9(r)-24.1(ea)15(tment &)20( )]TJ 0 Tc 0.32 Tw -5.263 -1.25 Td [(Mana)-17(gement. In Medscape; A)15.1(v)-15(ail)-16(able a)15(t ht)-30(tps://emedic)-23.9(ine.med)]TJ 0 Tw (-)Tj 0.023 Tw T* [(scape.com/ar)-21.9(t)-32(icle/936799-tr)-23.9(ea)15(tment. 2020 A)-24.9(ccessed 12 N)-14(ov, 2023.)]TJ -0.027 Tw T* (5.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(R)-10(a)-24(zumovsk)-15.9(ij)]TJ /Span<>> BDC ( )Tj EMC 5.241 0 Td [(A.Y)35(u., )0.6(Dr)-32(onov)]TJ /Span<>> BDC ( )Tj EMC 5.572 0 Td [(A.F. )0.6(P)30(edia)15(tr)-37(ic )0.6(sur)-32(ger)-23.9(y. )0.5(Na)15(t)-32(ional )0.6(leader)]TJ 0 Tw 15.177 0 Td (-)Tj 0.023 Tw -27.286 -1.25 Td [(ship. M)-24(osco)-13.9(w. GEOT)35(AR-Media. 2021; 1078 p. \(in Russ.\).)]TJ 0.002 Tc 0.349 Tw T* (6.)Tj /Span<>> BDC ( )Tj EMC 1.301 0 Td [(Cl)-30.5(inica)0.5(l ch)0.5(ar)-32.6(a)-16.6(c)-15.5(ter)-36.5(ist)-31.6(ic)0.5(s of g)0.5(astr)-31.6(o)0.5(inte)0.5(st)-31.6(in)0.5(al t)0.5(r)-32.6(a)-16.6(c)-15.6(t)0.5( du)0.5(pl)-30.6(ic)0.5(a)15.4(t)-31.6(io)0.5(ns)2( )]TJ 0 Tc 0.243 Tw -1.301 -1.25 Td [(in childr)-24(en: A single-inst)-31.9(i)-24(tut)-32(ion ser)-37(ies r)-24(ev)-16(iew. L)-32(i Xiang, Jiaming )]TJ 0.094 Tw T* [(L)-32(an, Bail)-31(in Chen, P)-24(ing L)-32(i, Chunbao Guo. )]TJ /T1_3 1 Tf (Medicine \(Baltimore\).)Tj /T1_2 1 Tf ( 2019 )Tj 0.236 Tw 29.055 20 Td [(N)-14(ov;98\(44\):e17682. P)20(ubl)-30.9(ished onl)-31(ine 2019 N)-14(ov 1. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1097/)Tj T* (MD.0000000000017682)Tj 0 0 0 1 k /GS1 gs 0.252 Tw T* (7.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Ok)-17(amo)17(t)17(o)]TJ /Span<>> BDC ( )Tj EMC [(T, T)40(ak)-17(amiza)10(w)-12(a)]TJ /Span<>> BDC ( )Tj EMC [(S, Y)40(okoi)]TJ /Span<>> BDC ( )Tj EMC [(A, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Com)10(ple)-12(tel)35.1(y isol)-15.9(a)15(ted )]TJ 0.191 Tw -1.296 -1.25 Td [(al)-31(iment)15.1(ar)-24(y tr)-33(a)-17(c)-16(t dupl)-31(ica)15.1(t)-32(ion in a neona)15(te. )]TJ /T1_3 1 Tf [(P)15(ediatr Surg Int)]TJ /T1_2 1 Tf (. 2008 )Tj 0.023 Tw T* [(O)-16(c)-16(t;24\(10\):1145\2267. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1007/s00383-008-2220-y)Tj 0 0 0 1 k /GS1 gs 0.222 Tw T* (8.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Mar)-22(t)-32(ini)]TJ /Span<>> BDC ( )Tj EMC [(C, P)40(a)-17(gano)]TJ /Span<>> BDC ( )Tj EMC [(P, P)30(er)-24(r)-32(one)]TJ /Span<>> BDC ( )Tj EMC [(G, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Intest)-32(inal dupl)-31(ica)15.1(t)-32(ions: )]TJ 0.116 Tw -1.296 -1.25 Td [(inc)-24(ident)15.1(all)35(y ileum dupl)-30.9(ica)15(t)-32(ion cy)-12.9(st in young female. )]TJ /T1_3 1 Tf [(BJR Case R)21(ep)]TJ /T1_2 1 Tf 0 Tw (. )Tj 0.023 Tw T* [(2019;5:20180077. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw [(10.1259/bjr)-32(cr.20180077)]TJ 0 0 0 1 k /GS1 gs 0.005 Tc 0.35 Tw T* (9.)Tj /Span<>> BDC ( )Tj EMC 1.311 0 Td [(McNut)-29.9(t)]TJ /Span<>> BDC ( )Tj EMC 3.562 0 Td [(R, )0.5(S)-23.9(chmi)-24(t)-29.9(t)]TJ /Span<>> BDC ( )Tj EMC 5.133 0 Td [(D, )0.5(S)-23.9(chul)56(te)]TJ /Span<>> BDC ( )Tj EMC 4.944 0 Td [(W. )0.5(Giant )0.6(col)30(onic )0.6(di)-15.9(ver)-22(t)-31.9(icul)-16(a-)]TJ 0 Tc 0.2 Tw -14.949 -1.25 Td [(t)-13(hr)-23.9(ee dist)-32(inc)-16(t ent)-32(i)-24(t)-32(ies. R)13(epor)-21.9(t of a case. )]TJ /T1_3 1 Tf [(Dis Colon R)21(ectum.)]TJ /T1_2 1 Tf ( 1988 )Tj 0.023 Tw T* [(A)10(ug;31\(8\):624\2268. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1007/BF02556799)Tj 0 0 0 1 k /GS1 gs 0.019 Tc 0.696 Tw T* (10.)Tj /Span<>> BDC ( )Tj EMC 1.873 0 Td [(Gonz\341lez-V)24.7(al)29.8(ver)-24.2(de)]TJ /Span<>> BDC ( )Tj EMC [(FM, Madr)-37.2(id-Ba\361os B, Ruiz-Mar\355n)]TJ /Span<>> BDC ( )Tj EMC [(M.)19( )]TJ 0.008 Tc 0.35 Tw -1.873 -1.25 Td [(Giant Di)-16.4(ver)-22.4(t)-32.4(icul)34.7(um of t)-13.4(he S)-16.4(igmoid Col)29.6(on. )]TJ /T1_3 1 Tf (J Gastrointest Surg)Tj /T1_2 1 Tf 0 Tc 0 Tw (. )Tj 0.023 Tw T* [(2021;25:1347\2261349. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1007/s11605-020-04841-x)Tj 0 0 0 1 k /GS1 gs 0.228 Tw T* (11.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Cho)-16(ong)]TJ /Span<>> BDC ( )Tj EMC [(CK, F)10(r)-36.9(izelle)]TJ /Span<>> BDC ( )Tj EMC [(F)24(A. Giant col)30(onic di)-16(ver)-22(t)-31.9(icul)35(um. )]TJ /T1_3 1 Tf (Dis Colon )Tj 0 Tw -1.796 -1.25 Td [(R)21(ectum.)]TJ /T1_2 1 Tf 0.023 Tw [( 1998;41:1178\2261185. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1007/BF02239441)Tj /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\037\035\030\213\030\003\t\021\037\030\t \213\b\214\035\200)15(\255\t\213\030\027)]TJ 54.711 0 Td [(C)10(A)20(SE REPORT)]TJ /T1_4 1 Tf 25 0 0 25 504.7397 56.0378 Tm (141)Tj ET endstream endobj 933 0 obj <>/Border[0 0 0]/H/N/Rect[57.2978 639.291 162.473 629.995]/Subtype/Link/Type/Annot>> endobj 934 0 obj <>/Border[0 0 0]/H/N/Rect[466.151 719.291 496.063 709.995]/Subtype/Link/Type/Annot>> endobj 935 0 obj <>/Border[0 0 0]/H/N/Rect[274.961 709.291 351.112 699.995]/Subtype/Link/Type/Annot>> endobj 936 0 obj <>/Border[0 0 0]/H/N/Rect[356.396 679.291 449.428 669.995]/Subtype/Link/Type/Annot>> endobj 937 0 obj <>/Border[0 0 0]/H/N/Rect[351.013 649.291 430.316 639.995]/Subtype/Link/Type/Annot>> endobj 938 0 obj <>/Border[0 0 0]/H/N/Rect[349.877 619.291 419.564 609.995]/Subtype/Link/Type/Annot>> endobj 939 0 obj <>/Border[0 0 0]/H/N/Rect[359.461 589.291 456.484 579.995]/Subtype/Link/Type/Annot>> endobj 940 0 obj <>/Border[0 0 0]/H/N/Rect[386.975 569.291 456.662 559.835]/Subtype/Link/Type/Annot>> endobj 941 0 obj <>/Border[0 0 0]/H/N/Rect[57.2978 432.265 162.473 422.969]/Subtype/Link/Type/Annot>> endobj 942 0 obj <>/Border[0 0 0]/H/N/Rect[466.151 512.265 496.063 502.969]/Subtype/Link/Type/Annot>> endobj 943 0 obj <>/Border[0 0 0]/H/N/Rect[274.961 502.265 351.112 492.969]/Subtype/Link/Type/Annot>> endobj 944 0 obj <>/Border[0 0 0]/H/N/Rect[356.396 472.265 449.428 462.969]/Subtype/Link/Type/Annot>> endobj 945 0 obj <>/Border[0 0 0]/H/N/Rect[351.013 442.265 430.316 432.969]/Subtype/Link/Type/Annot>> endobj 946 0 obj <>/Border[0 0 0]/H/N/Rect[349.877 412.265 419.564 402.969]/Subtype/Link/Type/Annot>> endobj 947 0 obj <>/Border[0 0 0]/H/N/Rect[359.461 382.265 456.484 372.969]/Subtype/Link/Type/Annot>> endobj 948 0 obj <>/Border[0 0 0]/H/N/Rect[386.975 362.265 456.662 352.809]/Subtype/Link/Type/Annot>> endobj 964 0 obj <> endobj 963 0 obj <> endobj 962 0 obj <> endobj 961 0 obj <> endobj 960 0 obj <> endobj 959 0 obj <> endobj 958 0 obj <> endobj 957 0 obj <> endobj 956 0 obj <> endobj 955 0 obj <> endobj 954 0 obj <> endobj 953 0 obj <> endobj 952 0 obj <> endobj 951 0 obj <> endobj 950 0 obj <> endobj 949 0 obj <> endobj 757 0 obj <>/ExtGState<>/Font<>/ProcSet[/PDF/Text]/Properties<>/Shading<>/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 758 0 obj <>/Font<>/ProcSet[/PDF/Text/ImageC]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 759 0 obj <>/Font<>/ProcSet[/PDF/Text/ImageB]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 760 0 obj <>/Font<>/ProcSet[/PDF/Text/ImageC]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 761 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 979 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.016 Tc 0.139 Tw 10 0 0 10 70.8661 724.8299 Tm (\022\017\001\022\017. \203\036\024\002\b\024\007\017\n\024\f\021\034 \007\ \017\235\235\036\030\036\027\006\017\026\006\017\017 \024\002\031\f\035\024\ \r)Tj 0 Tc 0 Tw (-)Tj 0.016 Tc 0.082 Tw 0 -1.218 TD (\035\036\027\026 \030\026\035\017\004\017\016\n\017 \r)Tj /Span<>> BDC ( )Tj EMC (\b\017\030\031\030\020\017\004\036\f\022\024\n \023\024\007\b\024\007\036\ . \200)Tj /Span<>> BDC ( )Tj EMC (\f\035\031)Tj 0 Tc 0 Tw (-)Tj 0.016 Tc 0.3 Tw T* (\004\026\036 \007\017\r\036\030\021\017\022\031\035\016\030\027\024\005 \ \002\024\035\036\027\017 \024\023\036\030\026\006\017\016 \023\030\036\007\ \023\024)Tj 0 Tc 0 Tw (-)Tj 0.016 Tc 0.141 Tw T* [(\035\026\020\026\036\021 \030\036\036\022\006\017\033 \035\036\r\t\b \024\ \021\007\036\035\024\r \024\002\024\007\024\004\027\024\005 \022\017\001\ \022\017)16( )]TJ -0.036 Tw T* (\r\n\036\f\021\036 \f)Tj /Span<>> BDC ( )Tj EMC [(\007\017\r\036\030\021\017\022\031\035\024\n \007\035\016 \023\030\024\235\ \017\035\026\022\021\017\022\017 \030\036\006\017\007\017\r\026)16( )]TJ 0.151 Tw T* (\r\024\f\023\026\035\017\021\036\035\034\027\t\b \024\f\035\024\032\027\036\ \027\017\005. \215\030\017)Tj /Span<>> BDC ( )Tj EMC (\035\036\004\036\027\017\017 \031\007\r\024\036)Tj 0 Tc 0 Tw (-)Tj 0.016 Tc 0.121 Tw 0 -1.218 TD [(\027\017\016 )0.5(\007\024\f\021\026\021\024\004\027\024 )0.5(\031\007\026\035\036\027\017\016 )0.5(\021\024\035\034\022\024 )0.5(\253\007\024\004\036\030\027\036\020\024\273 )0.5(\f\036\020)]TJ 0 Tc 0 Tw (-)Tj 0.016 Tc 0 -1.218 TD (\n\036\027\021\026, \022\026\022 \002\t\035\024 \f\007\036\035\026\027\024\ \r)Tj /Span<>> BDC ( )Tj EMC (\027\026\001\036\n \027\026\002\035\033\007\036\027\017\017.)Tj 0 Tc 0.287 Tw T* [(McNut)-30(t e)-12(t al. \022\035\026\f\f\017\235\017\006\017\030\024\r\026\035 \020\017\020\ \026\027\021\f\022\017\036 \007\017\r\036\030)]TJ 0 Tw (-)Tj 0.376 Tw T* (\021\017\022\031\035\t \021\024\035\f\021\024\005 \022\017\001\022\017 \027\ \026)Tj /Span<>> BDC ( )Tj EMC (\021\030\017 \021\017\023\026, \024\f\027\024\r\t\r\026\016\f\034 )Tj 0.046 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC (\220\021\017\024\035\024\020\017\017. \215\024)Tj /Span<>> BDC ( )Tj EMC (\007\026\027\027\024\005 \022\035\026\f\f\017\235\017\022\026\006\017\017\ , I \017)Tj /Span<>> BDC ( )Tj EMC (II \021\017\023\t )Tj 0.01 Tw T* (\016\r\035\016\033\021\f\016 \023\f\036\r\007\024\007\017\r\036\030\021\017\ \022\031\035\026\n\017 \017,)Tj /Span<>> BDC ( )Tj EMC (\f\022\024\030\036\036 \r\f\036\020\024, \017\n\036)Tj 0 Tw (-)Tj 0.028 Tw 0 -1.218 TD (\033\021 \024\021\027\024\001\036\027\017\036 \022)Tj /Span<>> BDC ( )Tj EMC (\007\017\r\036\030\021\017\022\031\035\016\030\027\024\005 \002\024\035\036\ \027\017. \202)Tj /Span<>> BDC ( )Tj EMC (\r\024\021 \021\017\023 )Tj -0.02 Tw 0 -1.218 TD (III)Tj /Span<>> BDC ( )Tj EMC (\227 \017\f\021\017\027\027\t\005 \007\017\r\036\030\021\017\022\031\035\ )Tj /Span<>> BDC ( )Tj EMC (\227 \036\f\035\017 \024\027 \002\024\035\034\001\024\005 \017)Tj /Span<>> BDC ( )Tj EMC (\031\007)Tj 0 Tw (-)Tj 0.143 Tw 0 -1.218 TD (\035\017\027\036\027\027\t\005, \036\020\024 \027\036\r\024\n\024\032\027\ \024 \024\021\035\017\004\017\021\034 \024\021 \007\031\023\035\017\022\026\ \006\017\017 )Tj 0 Tw T* ([9,10].)Tj -0.005 Tw T* [(\215\024 \022\035\026\f\f\017\235\017\022\026\006\017\017 Cho)-16(ong, F)10(r)-37(izelle \020\017\020\026\027\021\f\022\017\036 \007\017\r\036\030)]TJ 0 Tw (-)Tj 0.148 Tw T* (\021\017\022\031\035\t \007\036\035\016\021\f\016 \027\026)Tj /Span<>> BDC ( )Tj EMC (2 \021\017\023\026, \024\f\027\024\r\t\r\026\016\f\034 \027\026)Tj /Span<>> BDC ( )Tj EMC (\020\017\f\021\024\035\024)Tj 0 Tw (-)Tj 0.147 Tw T* (\020\017\017. \215\024)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\005 \032\036 \022\035\026\f\f\017\235\017\022\026\006\017\017\ \021\017\023 2 \016\r\035\016\036\021\f\016 \017\f)Tj 0 Tw (-)Tj 0.099 Tw T* (\021\017\027\027\t\n \(\r\030\024\032\007\036\027\027\t\n\) \007\017\r\036\ \030\021\017\022\031\035\024\n \017)Tj /Span<>> BDC ( )Tj EMC (\026\027\026\035\024\020\024\n III )Tj 0 Tw T* (\021\017\023\026 \023\024)Tj /Span<>> BDC ( )Tj EMC [(McNut)-29.9(t [11].)]TJ 0.152 Tw T* (\200\027\036 \026\r\017\f\017\n\024\f\021\017 \024\021 \022\035\026\f\f\ \017\235\017\022\026\006\017\017, \020\017\020\026\027\021\f\022\017\005\ \007\017)Tj 0 Tw (-)Tj 0.046 Tw T* (\r\036\030\021\017\022\031\035 \021\024\035\f\021\024\005 \022\017\001\022\ \017 \021\017\023\026 III \023\024)Tj /Span<>> BDC ( )Tj EMC [(McNut)-30(t \017)]TJ /Span<>> BDC ( )Tj EMC (\021\017\023\026 II )Tj 0.094 Tw T* (\023\024)Tj /Span<>> BDC ( )Tj EMC [(Cho)-16(ong \017)]TJ /Span<>> BDC ( )Tj EMC [(F)10(r)-37(izelle \027\036\024\021\035\017\004\017\n \024\021 \031\007\r\024\036\027\ \017\016 \021\024\035\f\021\024\005 )]TJ 0.138 Tw T* (\022\017\001\022\017, \024\f\024\002\036\027\027\024 \036\f\035\017 \024\ \027 \031\007\035\017\027\036\027\027\t\005, \007\017\r\036\030\021\017\022\ \031\035\t )Tj 0.224 Tw T* [(\032\036 )0.5(\004\026\013\036 )0.5(\f\235\036\030\017\004\036\f\022\024\005 )0.5(\235\024\030\n\t )0.5([9\22611]. )0.5(\212\031\002\035\017\022\026\021\031\030\031 )]TJ 0.205 Tw T* (\n\024\032\027\024 \024\021\035\017\004\017\021\034, \036\f\035\017 \031\ \004\026\f\021\024\022 \f\024\007\036\030\032\017\021 \020\035\026\007\022\ \024\n\t)Tj 0 Tw (-)Tj 0.01 Tw T* (\001\036\004\027\031\033 \f\021\036\027\022\031 \017)Tj /Span<>> BDC ( )Tj EMC (\f\035\017\017\f\021\031\033 \024\002\024\035\024\004\022\031 \022\017\001\ \036\004\027\017\022\026, \021\026\022 )Tj 0.246 Tw T* (\032\036 \023\024\030\024\022 \026\021\030\026\020\017\r\026\036\021 \002\ \030\t\032\036\036\004\027\031\033 \f\021\024\030\024\027\031 \022\017\001\ \022\017 )Tj 0.086 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC [(\017\n\036\036\021 \024\002\013\036\036 \022\030\024\r\024\f\027\026\002\ \032\036\027\017\036 )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC [(\031\004\026\f\021\022\024\n )0.5(\027\036\f\031\013\036\005 )]TJ 0 Tw T* (\022\017\001\022\017.)Tj 0.199 Tw T* (\212\026\027\027\t\005 \022\035\017\027\017\004\036\f\022\017\005 \f\035\ \031\004\026\005 \002\t\035 \030\026\f\006\036\027\036\027 \022\026\022 \ \031\007)Tj 0 Tw (-)Tj 0.035 Tw T* (\r\024\036\027\017\036 \021\024\035\f\021\024\005 \022\017\001\022\017, \ \021\026\022 \022\026\022 \024\002\030\026\024\r\026\027\017\036 \002\t\ \035\024 \021\031)Tj 0 Tw (-)Tj 0.086 Tw T* (\002\031\035\016\030\027\024\005 \235\024\030\n\t, \024\002\035\026\007\026\ \035\024 \f\024\002\f\021\r\036\027\027\024\005 \002\030\t\032\036\005\022\ \024\005 )Tj -0.009 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\020\017\f\021\024\035\024\020\017\004\036\f\022\017 \023\030\036\007\f\021\ \026\r\035\036\027\024 \r\f\036\n\017 \f\035\024\016\n\017 \022\017\001\036\ \004)Tj 0 Tw (-)Tj T* (\027\024\005 \f\021\036\027\022\017.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 70.936 262.0658 Tm [(\020)21(\026\027\r\242\224\034\022\031\034)]TJ 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0 Tc 0.118 Tw 10 0 0 10 70.8661 237.7098 Tm (\211\007\r\024\036\027\017\036 \f\017\020\n\024\r\017\007\027\024\005 \022\ \017\001\022\017)Tj /Span<>> BDC ( )Tj EMC (\227 \220\021\024 \030\036\007\022\026\016 \007\024\002\030\024)Tj 0 Tw (-)Tj 0.141 Tw T* [(\022\026\004\036\f\021\r\036\027\027\026\016 )0.5(\026\027\024\n\026\035\017\016 \030\026\r\017\021\017\016 \024\002\024\007\ \024\004\027\024\005 )0.5(\022\017\001\022\017, )]TJ 0.102 Tw T* (\022\024\021\024\030\026\016, \024\007\027\026\022\024, \n\024\032\036\021\ \023\024\021\030\036\002\024\r\026\021\034 \b\017\030\031\030\020\017\004\ \036\f\022\024\020\024 )Tj 0.245 Tw T* (\035\036\004\036\027\017\016 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\030\026\r\017\021\017\017 \024\f\035\024\032\027\036\027\017\005. \216\ \017\030\031\030\020\017\004\036\f\022\026\016 )Tj 0.187 Tw T* (\021\026\022\021\017\022\026 \r)Tj /Span<>> BDC ( )Tj EMC (\f\035\031\004\026\036 \031\007\r\024\036\027\017\016 \024\021\035\017\004\ \026\036\021\f\016 \024\021 \023\024\007\b\024\007\024\r )Tj 0.498 Tw T* (\022)Tj /Span<>> BDC ( )Tj EMC (\035\036\004\036\027\017\033 \007\017\r\036\030\021\017\022\031\035\016\030\ \027\024\005 \002\024\035\036\027\017 \024\002\024\007\024\004\027\024\005\ )Tj 0.108 Tw T* (\022\017\001\022\017, \023\024\220\021\024\n\031 \b\017\030\031\030\020\031\ \027\036\024\002\b\024\007\017\n\024 \023\024\n\027\017\021\034 \024)Tj /Span<>> BDC ( )Tj EMC (\r\024)Tj 0 Tw (-)Tj T* (\n\024\032\027\024\f\021\017 \021\026\022\024\020\024 \023\024\030\024\022\ \026 \030\026\r\017\021\017\016.)Tj /T1_2 1 Tf 0 -2.436 TD (\225\035\032\027\017\031\032\022\025\017\255\020\034:)Tj /T1_0 1 Tf 0.489 Tw ( \202\r\021\024\030\t \r\t\030\026\032\026\033\021 \023\030\017\027\026\ \021\036\035\034)Tj 0 Tw (-)Tj 0.176 Tw 0 -1.218 TD [(\027\024\f\021\034 )0.5(\026\n\036\f\021\017\021\036\035\033 )0.6(\020\035\026\r\027\024\020\024 )0.6(\r\030\026\004\026 )0.5(\023\024)]TJ /Span<>> BDC ( )Tj EMC 16.606 0 Td (\n\036\007\017\006\017\027\f\022\024\005 )Tj 0.238 Tw -16.606 -1.218 Td (\004\026\f\021\017 \210\013\036\023\022\024\r\031 \202\027\007\030\036\033\ \200\035\026\007\017\n\017\030\024\r\017\004\031 \026)Tj /Span<>> BDC ( )Tj EMC (\023\030\036\007\024)Tj 0 Tw (-)Tj 0.204 Tw T* (\f\021\026\r\035\036\027\027\031\033 \r\024\n\024\032\027\024\f\021\034\ \024\023\017\f\026\021\034 \007\026\027\027\t\005 \022\035\017\027\017\004\ \036)Tj 0 Tw (-)Tj 0.028 Tw T* (\f\022\017\005 \f\035\031\004\026\005, \026)Tj /Span<>> BDC ( )Tj EMC (\021\026\022 \032\036 \234\021\031\022\017\027\024\005 \203\026\021\026\035\ \034\036 \202\030\022\026\007\034\036\r\027\036, )Tj 0.285 Tw 23.244 64.543 Td (\207\026\001\022\017\030\006\036\r\024\005 \230\026\021\034\016\027\036 \ \236\030\034\036\r\027\036 \026)Tj /Span<>> BDC ( )Tj EMC (\023\030\036\007\024\f\021\026\r\035\036\027\017\036 )Tj 0 Tw 0 -1.218 TD (\030\036\031\035\034\021\026\021\024\r \017\f\f\035\036\007\024\r\026\027\ \017\016.)Tj /T1_2 1 Tf 0 -2.436 TD [(A)16(CKNO)14(WLEDGMENT)-22.9(S:)]TJ /T1_0 1 Tf 0.065 Tw [( T)47(he aut)-13(hor)-10(s e)-18(xp)25.1(r)-24(ess t)-13(heir gr)-33(a)15(t)-31.9(i)]TJ 0 Tw (-)Tj 0.071 Tw 0 -1.218 TD [(tude t)17(o t)-13(he Deput)-10(y Chief Phy)-13(sic)-23.9(ian for Medical Af)-56(f)16(air)-10(s )]TJ 0.346 Tw T* [(Andr)-24(e)-10.9(y Vl)-15.9(adimir)-32(ov)-16(ich )0.5(Oshchepkov )0.5(for )0.6(t)-13(he )0.5(oppor)-22(tu)]TJ 0 Tw (-)Tj 0.16 Tw 0 -1.218 TD [(ni)-24(t)-10(y t)17(o descr)-36.9(ibe t)-13(his cl)-31(inical )0.5(case, as )0.5(well as Na)15(t)15(al)35(y)22(a )]TJ 0.224 Tw 0 -1.218 TD [(Ar)-24(k)-17(ad)17(yevna S)-16(htuk)-15.9(ina, T)39.9(a)15(t)-9.9(y)22(ana Y)35(ur)-23.9(yevna Bashk)-16(ir)-22(tsev)-14.9(a )]TJ 0 Tw T* [(for p)25(r)-32(ov)-15.9(iding t)-13(he r)-23.9(esear)-32(ch r)-23.9(esul)56(ts.)]TJ /T1_2 1 Tf 0.023 Tw 0 -2.436 TD (\223\030\032\255\020\034\036 \032\026\020\017\022\017\026)Tj /T1_0 1 Tf 0.956 Tw 0 -1.218 TD [(\221)-4.6(\002)-9.9(\024)0.7(\030 \017)]TJ /Span<>> BDC ( )Tj EMC [(\024)-11.8(\002)3(\030)-11.4(\026)-6.3(\002)-9.9(\024)-10.9(\021)-17.7(\022)-19.1(\026 \n)1.2(\026)-11.8(\021)-9.8(\036)-1.7(\030)-7.6(\017)-0.6(\026)-33.1(\035\026)3.7(:)]TJ /T1_3 1 Tf -0.01 Tc 0.966 Tw [( \224)-4.1(\205)-3.4(\t\n\027)-7.8(\026)]TJ /Span<>> BDC 19.048 0 Td ( )Tj EMC [(\222)-1.4(.)-2.7(\201)-12.3(.)-2.2(,)-9.9( )]TJ 0.01 Tw -19.048 -1.218 Td [(\207)-5.5(\024)-3.1(\026)-8.2(\032)-4(\013\n\027)]TJ /Span<>> BDC 3.48 0 Td ( )Tj EMC [(\215)18.8(.)-17.8(\035)15.1(.)]TJ /T1_0 1 Tf 0.002 Tc -0.002 Tw -3.48 -1.218 Td [(\203)7.2(\026\023)4.2(\017\f)-10.8(\026)1.7(\027)3.7(\017)-6.7(\036)2.1( \021)-7.9(\036)-3.4(\022\f)-34(\021)-19.5(\026)5.7(:)]TJ /T1_3 1 Tf -0.01 Tc 0.01 Tw 7.694 0 Td [( \224)-4.1(\205)-3.4(\t\n\027)-7.9(\026)]TJ /Span<>> BDC 2.995 0 Td ( )Tj EMC [(\222)-1.4(.)-2.7(\201)-12.2(.)]TJ /T1_0 1 Tf 0 Tc 0.756 Tw -10.689 -1.218 Td [(\217)5.5(\036)-19(\007)-20.1(\026\022)-32.6(\021)-17.7(\017)1.4(\030)-11.8(\024)-4.2(\r)-9(\026\027)1.8(\017)-8.7(\036)-20.3(, )0.5(\024)-4.1(\007)-4.4(\024)-11.8(\002)3(\030)-16.2(\036)-5.4(\027)1.7(\017)-8.7(\036 )0.5(\235)-6.1(\017)1.8(\027)-0.6(\026)-33.1(\035)2.2(\034\027)-4.3(\024)-4.3(\005 )0.5(\r)-8.5(\036)-1.7(\030)-9.9(\f)-1.6(\017)1.7(\017 )]TJ 0.002 Tc -0.002 Tw T* [(\030)-8.8(\031)-9.3(\022)1.3(\024)-2.3(\023)4.2(\017\f\017)15.2(:)]TJ /T1_3 1 Tf -0.004 Tc 0.004 Tw 4.194 0 Td [( \213)-2.9(\n)1.9(\202\030)0.8(\026\021\n)5.6(\027)]TJ /Span<>> BDC 4.021 0 Td ( )Tj EMC [(\201)-6.3(.)24.5(\216)20.3(.)]TJ /T1_2 1 Tf 0 Tc 0.023 Tw -8.214 -2.436 Td (AUTHORS CONTRIBUTION)Tj /T1_0 1 Tf 1.014 Tw T* [(C)-6.5(o)-5.8(l)-19(l)-14.3(e)-9.4(c)-32.5(t)-37.3(i)3.2(o)0.8(n )0.5(a)2.4(n)-4.6(d )0.6(p)-3.8(r)-6(o)-7(ce)-13.3(s)-12.8(s)-16.6(i)7.1(n)-1.9(g )0.6(o)-2.2(f )0.5(t)-16.6(h)-5.3(e )0.5(m)1.8(a)-8.4(t)-15.1(e)-2.1(r)-48(i)5.1(a)-1.5(l)-22.5(:)]TJ /T1_3 1 Tf 0 Tw ( )Tj T* [(K)-21.9(s)4.9(e)-2.6(n)6.2(i)5.9(a)]TJ /Span<>> BDC ( )Tj EMC [(A)-12.5(.)]TJ /Span<>> BDC ( )Tj EMC [(C)3.2(h)8.2(us)4.9(o)-0.6(v)10.8(a)-14(, I)3.2(l)11.1(y)3.8(a)]TJ /Span<>> BDC ( )Tj EMC [(L)-8.8(.)]TJ /Span<>> BDC ( )Tj EMC [(S)16.3(t)2.3(ar)-2.5(k)12.9(o)-0.6(v)33.6(,)]TJ /T1_0 1 Tf T* [(W)3.1(r)-48(i)-6(t)-37.4(i)7.1(n)-1.9(g o)-2.2(f t)-16.7(h)-5.3(e t)-15.2(e)-23.9(x)-36(t)-20(:)]TJ /T1_3 1 Tf [( K)-21.9(s)4.9(e)-2.6(n)6.2(i)5.9(a)]TJ /Span<>> BDC ( )Tj EMC [(A)-12.6(.)]TJ /Span<>> BDC ( )Tj EMC [(C)3.3(h)8.2(us)4.9(o)-0.6(v)10.8(a)]TJ /T1_0 1 Tf -0.045 Tw T* [(E)5.6(d)-6(i)-6(t)-37.4(i)7.1(n)-1.9(g)-20.5(, a)1.3(p)-2.4(p)-3.8(r)-6(ov)-19.1(a)-1.5(l o)-2.2(f t)-16.7(h)-5.3(e \237)6.2(n)2.2(a)-1.5(l v)-8.9(e)-2.1(r)-21(s)-16.6(i)3.2(o)0.8(n o)-2.3(f t)-16.7(h)-5.3(e m)1.8(a)2.4(n)2.5(u)-12.3(s)-7.9(c)-12.8(r)-48(i)7.7(p)-12.4(t)-20(:)]TJ /T1_3 1 Tf 0 Tw ( )Tj -0.002 Tc 0.002 Tw T* [(A)1.6(l)2.8(e)-30.6(xe)-4.5(y)]TJ /Span<>> BDC 2.539 0 Td ( )Tj EMC [(V)51.1(.)]TJ /Span<>> BDC 0.955 0 Td ( )Tj EMC [(B)-1.2(o)-6.4(g)-4.5(da)-2.7(no)-2.6(v)]TJ /T1_2 1 Tf 0 Tc 0.023 Tw -3.493 -2.436 Td (\255\026\036\031\036\025\034\224 \017\225 \032\026\020\017\022\032\221 \(\ ORCID\))Tj /T1_0 1 Tf 0.42 Tw T* (\223\031\f\024\r\026 \025\f\036\027\017\016 \202\027\007\030\036\036\r\027\ \026)Tj /Span<>> BDC ( )Tj EMC (\227 \f\021\031\007\036\027\021 \205\206\207\210\211 \200\210 )Tj 1.892 Tw T* (\211\030\026\035\034\f\022\024\020\024 \020\024\f\031\007\026\030\f\021\r\ \036\027\027\024\020\024 \n\036\007\017\006\017\027\f\022\024\020\024 )Tj 0 Tw T* (\031\027\017\r\036\030\f\017\021\036\021\026)Tj 0.059 Tw T* (\207\024\020\007\026\027\024\r \202\035\036\022\f\036\005 \200\035\026\007\ \017\n\017\030\024\r\017\004)Tj /Span<>> BDC ( )Tj EMC (\227 \r\030\026\004 \b\017\030\031\030\020-\022\024)Tj 0 Tw (-)Tj 0.231 Tw T* [(\035\024\023\030\024\022\021\024\035\024\020-\024\027\022\024\035\024\020\ , )0.6(\026\f\f\017\f\021\036\027\021 )0.6(\022\026\235\036\007\030\t )0.5(\b\017\030\031\030\020\017\017, )]TJ -0.007 Tw T* (\022\024\035\024\023\030\024\022\021\024\035\024\020\017\017 \017)Tj /Span<>> BDC ( )Tj EMC (\220\027\007\024\f\022\024\023\017\017 \205\206\207\210\211 \200\210 \211\ \030\026\035\034\f\022\024\020\024 )Tj 0.088 Tw T* (\020\024\f\031\007\026\030\f\021\r\036\027\027\024\020\024 \n\036\007\017\ \006\017\027\f\022\024\020\024 \031\027\017\r\036\030\f\017\021\036\021\026\ , \026\r\036)Tj 0 Tw (-)Tj 0.112 Tw T* (\007\031\033\013\017\005 \024\021\007\036\035\036\027\017\016 \026\002\007\ \024\n\017\027\026\035\034\027\024\020\024 \024\027\022\024\035\024\020\017\ \017 \206\202\211\003 )Tj 0 Tw T* (\221\210 \221\210\025\207 \2251 \020. \213\022\026\021\036\030\017\027\002\ \031\030\020\026)Tj 0.071 Tw T* (\221\021\026\030\022\024\r \222\035\034\016 \214\036\024\027\017\007\024\ \r\017\004)Tj /Span<>> BDC ( )Tj EMC (\227 \r\030\026\004 \b\017\030\031\030\020-\022\024\035\024\023\030\024\022\ )Tj 0 Tw (-)Tj 0.209 Tw T* (\021\024\035\024\020 \r\t\f\001\036\005 \022\026\021\036\020\024\030\017\ \017 \024\021\007\036\035\036\027\017\016 \026\002\007\024\n\017\027\026\ \035\034\027\024\005 )Tj 0 Tw T* (\024\027\022\024\035\024\020\017\017 \206\202\211\003 \221\210 \221\210\025\ \207 \2251 \020. \213\022\026\021\036\030\017\027\002\031\030\020\026)Tj /T1_2 1 Tf 0.023 Tw 0 -2.436 TD (INFORMATION ABOUT THE AUTHORS \(ORCID\))Tj /T1_0 1 Tf 0.28 Tw 0 -1.218 TD [(K)25(senia )0.5(A. Chusov)-14.9(a)]TJ /Span<>> BDC ( )Tj EMC [(\227 student )0.5(of )0.5(t)-13(he F)10(eder)-32.9(al S)15(t)15(a)15(te )]TJ 0.233 Tw T* [(Budge)-12(t Educa)15.1(t)-32(ional Inst)-32(i)-24(tut)-31.9(ion of Higher Educa)15(t)-31.9(ion )]TJ 0 Tw T* [(\253U)15(r)-33(al S)15.1(t)15(a)15(te Medical U)13(ni)-15.9(ver)-10(si)-24(t)-9.9(y\273)]TJ 0.471 Tw T* [(Alek)-10(se)-10.9(y V. Bo)-16(gd)42(anov)]TJ /Span<>> BDC ( )Tj EMC [(\227 sur)-32(geon-col)30(op)25(r)-32(o)-16(c)-15.9(t)17(ol)30(o)-16(gist-)]TJ 0.194 Tw T* [(end)-16(oscopist, assist)15.1(ant a)15(t t)-12.9(he Dep)32(ar)-22(tment of Sur)-32(ger)-24(y, )]TJ 0.301 Tw T* [(Col)30(op)25(r)-32(o)-16(c)-16(t)17.1(ol)30(o)-16(g)16(y and End)-16(oscopy )0.5(of t)-13(he F)10(eder)-32.9(al S)15(t)15(a)15(te )]TJ 0.233 Tw T* [(Budge)-12(t Educa)15.1(t)-32(ional Inst)-32(i)-24(tut)-31.9(ion of Higher Educa)15(t)-31.9(ion )]TJ 0.197 Tw T* [(\253U)15(r)-33(al )0.5(S)15.1(t)15(a)15(te )0.5(Medical )0.5(U)13(ni)-16(ver)-10(si)-23.9(t)-10(y\273, )0.5(head )0.5(of )0.5(t)-13(he )0.6(dep)31.9(ar)-21.9(t)]TJ 0 Tw (-)Tj -0.019 Tw T* [(ment of abd)-16(ominal oncol)30(o)-16(g)16(y of t)-13(he Sver)-24(dl)30.1(ovsk R)13(egional )]TJ 0 Tw T* [(Cl)-31(inical Hospi)-23.9(t)15(al N)-13.9(o. 1 of Y)30(ek)-16.9(a)15(ter)-37(inbur)-32(g)]TJ -0.03 Tw T* [(Il)35(y)22(a L. S)15(t)15(ar)-24(kov)]TJ /Span<>> BDC ( )Tj EMC [(\227 sur)-32(geon-col)30.1(op)25(r)-32(o)-16(c)-16(t)17(ol)30(o)-16(gist of t)-12.9(he high)]TJ 0 Tw (-)Tj 0.015 Tw T* [(est ca)15(tegor)-24(y in t)-13(he Dep)32(ar)-22(tment of A)-14(bd)-16(ominal Oncol)30(o)-15.9(g)16(y )]TJ 0.161 Tw T* [(of t)-13(he Sver)-24(dl)30.1(ovsk R)13(egional Cl)-30.9(inical Hospi)-24(t)15(al N)-14(o. 1 of )]TJ 0 Tw T* [(Y)30(ek)-17(a)15(ter)-36.9(inbur)-32(g)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\037\035\030\213\030\003\t\021\037\030\t \213\b\214\035\200)15(\255\t\213\030\027)]TJ 54.711 0 Td [(C)10(A)20(SE REPORT)]TJ -54.711 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 23, \023\0221)69(, 202)69(4)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 23, \023\0221)69(, 202)69(4)]TJ /T1_5 1 Tf 25 0 0 25 20.8528 56.0378 Tm (140)Tj ET endstream endobj 973 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\032)30(\215\f\215\007\205\002\001\025\016 \215\201\r\025\016\001\220\016 \006\220\ \202)10.1(\024\025\r\220\201\001\025\203 \n\220\n\220: )]TJ 0 -1 TD [(\025\221\220\006\013\001\220\016 \n)-10(\007\220\001\220\017\016\006\n)10(\025\202)10(\025 \006)-10(\007\215\017\013\205)]TJ 39.376 1 Td [(T)30(ubular duplication of th)11(e sigmoid colon: clinical case)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0.016 Tc 0.555 Tw 10 0 0 10 42.5197 724.8299 Tm [(\r\027\031\021\030\017\023\030\024\f\r\036\021\027\024\020\024 \007\026\r\ \035\036\027\017\016 \017, \022\026\022 \f\035\036\007\f\021\r\017\036,)16( )]TJ 0.105 Tw 0 -1.218 TD (\022)Tj /Span<>> BDC ( )Tj EMC [(\r\024\f\023\026\035\036\027\017\033 \022\017\001\036\004\027\024\005 \f\ \021\036\027\022\017 \031\007\r\024\036\027\027\024\005 \022\017\001\022\ \017.)16( )]TJ 0.189 Tw T* (\200)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\024\005 \f\017\021\031\026\006\017\017 \007\017\r\036\030\021\ \017\022\031\035\016\030\027\t\036 \017)Tj /Span<>> BDC ( )Tj EMC [(\021\031\002\031\035\016\030\027\t\036)16( )]TJ 0.205 Tw T* [(\235\024\030\n\t )0.5(\031\007\r\024\036\027\017\016 )0.5(\024\002\024\007\024\004\027\024\005 )0.5(\022\017\001\022\017 )0.5(\021\030\036\002\031\033\021 )0.5(\007\017\235)]TJ 0 Tc 0 Tw (-)Tj 0.016 Tc 0.095 Tw T* (\235\036\030\036\027\006\017\026\035\034\027\024\005 \007\017\026\020\027\ \024\f\021\017\022\017 \f)Tj /Span<>> BDC ( )Tj EMC (\020\017\020\026\027\021\f\022\017\n\017 \007\017\r\036\030)Tj 0 Tc 0 Tw (-)Tj 0.016 Tc 0.1 Tw T* (\021\017\022\031\035\026\n\017, \024\002\030\026\031\033\013\017\n\017\f\ \016 \r)Tj /Span<>> BDC ( )Tj EMC (\030\036\031\035\034\021\026\021\036 \024\f\035\024\032\027\036\027)Tj 0 Tc 0 Tw (-)Tj 0.016 Tc 0.038 Tw 0 -1.218 TD [(\027\024\020\024 \021\036\004\036\027\017\016 \007\017\r\036\030\021\017\ \022\031\035\016\030\027\024\005 \002\024\035\036\027\017 \024\002\024\007\ \024\004\027\024\005)16( )]TJ ET q 42.52 473.431 221.102 156.966 re W n q /GS0 gs 221.1023475 0 0 157.0042763 42.5196986 473.3932849 cm /Im0 Do Q Q BT 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0 Tc 0 Tw 10 0 0 10 263.6221 473.4318 Tm ( )Tj 0.004 Tw 9 0 0 9 42.5197 462.6318 Tm [(\022\t\217\210\b\002\220 )0.5(4.)]TJ 0 0 0 1 k /GS1 gs /T1_3 1 Tf [( \215\021\024\032\026\n\033\031\032\026\203\025\n\021\021\026\002 )0.5(\f\n\024\n\202\032\026\f\025\002 )0.5(\n\005\032\026\016\n\027\026\021\025\002 )]TJ 0 Tw 0 -1.2 TD (\032\026\t\033\n\023\n\204\031\021\021\n\202\n \016\026\005\032\007\001\025\ \021\021\n \027)Tj /Span<>> BDC ( )Tj EMC (\003\031\016\n\202\026\t\024\032\025\025)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.067 Tw T* [(F)-16(igure 4.)]TJ 0 0 0 1 k /GS1 gs /T1_3 1 Tf [( Intraoperativ)13.1(e pho)13(tog)14(raph of the for)-13.9(mation located )]TJ 0 Tw T* [(retroper)-36.9(itoneal in the mesog)12.2(astr)-37(ium)]TJ ET q 42.52 122.596 221.102 297.131 re W n q /GS0 gs 221.1023475 0 0 298.4041521 42.5197177 122.4649084 cm /Im1 Do Q Q BT 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.124 Tw 9 0 0 9 42.5197 111.7958 Tm (\022\t\217\210\b\002\220 5.)Tj 0 0 0 1 k /GS1 gs /T1_3 1 Tf ( \240\026\013\032\n\033\032\031\033\026\032\026\024 \205\030\027\n\031\021\ \025\002 \t\025\202\003\n\027\025\030\021\n\017 \013\025\001\013\025 )Tj 0 Tw T* (\027)Tj /Span<>> BDC ( )Tj EMC (\032\026\016\032\031\016\031, \n\033\032\031\030\031\023\002\031\024\t\002\ \004\026\032\026\013\024\031\032\021\026\002 \t\013\023\026\030\006\026\ \024\n\t\024\022)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf -0.046 Tw T* [(F)-16(igure )0.6(5.)]TJ 0 0 0 1 k /GS1 gs /T1_3 1 Tf [( )0.5(Macro-p)46(reparation )0.5(of )0.6(doubling )0.5(of )0.6(the )0.5(sigmoid )0.6(colon )0.5(in )]TJ 0 Tw T* [(the section, the character)-36.8(istic folding is deter)-13.8(mined)]TJ ET q 274.961 583.258 221.102 153.751 re W n q /GS0 gs 221.1023768 0 0 155.0307653 274.9606332 583.2573733 cm /Im2 Do Q Q BT 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.168 Tw 9 0 0 9 274.9606 572.4573 Tm [(\022\t\217\210\b\002\220 )0.5(6.)]TJ 0 0 0 1 k /GS1 gs /T1_3 1 Tf [( \217\026\032\205\204\021\020\031 )0.5(\n\024\030\031\023\020 )0.5(\003\020\001\031\006\021\n\017 )0.5(\n\005\n\023\n\006\013\025, )0.5(\005\032\020)]TJ 0 Tw (-)Tj 0.143 Tw T* (\204\031\017\013\026 \025)Tj /Span<>> BDC ( )Tj EMC (\t\031\032\n\016\021\026\002 \n\005\n\023\n\006\013\026. \214\027\031\023\ \025\006\031\021\025\031)Tj /Span<>> BDC ( )Tj EMC (\327)Tj /Span<>> BDC ( )Tj EMC (40, \202\031\003\026\024\n\013\t\025)Tj 0 Tw (-)Tj T* (\023\025\021-\r\n\016\025\021)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf -0.052 Tw T* [(F)-16(igure 6)16(.)]TJ 0 0 0 1 k /GS1 gs /T1_3 1 Tf [( The outer par)-40(ts of the muscular membrane, mesenter)-43(y )]TJ 0 Tw T* (and serous membrane. Magni\233cation)Tj /Span<>> BDC ( )Tj EMC (\327)Tj /Span<>> BDC ( )Tj EMC [(40, hemato)14.4(xylin-eosin)]TJ ET q /GS0 gs 221.1023768 0 0 165.8267678 274.9606332 352.9266289 cm /Im3 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.313 Tw 9 0 0 9 274.9606 342.1266 Tm (\022\t\217\210\b\002\220 7.)Tj 0 0 0 1 k /GS1 gs /T1_3 1 Tf ( \207\023\025\016\025\t\024\026\002 \n\005\n\023\n\006\013\026, \033\n\030\ \t\023\025\016\025\t\024\026\002 \n\005\n\023\n\006)Tj 0 Tw (-)Tj 0.248 Tw T* (\013\026 \025)Tj /Span<>> BDC ( )Tj EMC (\027\021\205\024\032\031\021\021\025\031 \n\024\030\031\023\020 \003\020\ \001\031\006\021\n\017 \n\005\n\023\n\006\013\025. \214\027\031\023\025\006\ \031)Tj 0 Tw (-)Tj T* (\021\025\031)Tj /Span<>> BDC ( )Tj EMC (\327)Tj /Span<>> BDC ( )Tj EMC (40, \202\031\003\026\024\n\013\t\025\023\025\021-\r\n\016\025\021)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.052 Tw T* [(F)-16(igure 7)124(.)]TJ 0 0 0 1 k /GS1 gs /T1_3 1 Tf [( Mucous membrane, submucosa and inter)-14(nal par)-39.9(ts of )]TJ -0.04 Tw T* (the muscular membrane. Magni\233cation)Tj /Span<>> BDC ( )Tj EMC (\327)Tj /Span<>> BDC ( )Tj EMC [(40, hemato)14(xylin-eosin)]TJ ET q /GS0 gs 221.1023768 0 0 165.8267678 274.9606332 122.595967 cm /Im4 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf -0.037 Tw 9 0 0 9 274.9606 111.796 Tm (\022\t\217\210\b\002\220 8.)Tj 0 0 0 1 k /GS1 gs /T1_3 1 Tf ( \207\023\025\016\025\t\024\026\002 \n\005\n\023\n\006\013\026. \214\027\ \031\023\025\006\031\021\025\031)Tj /Span<>> BDC ( )Tj EMC (\327)Tj /Span<>> BDC ( )Tj EMC (40, \202\031\003\026\024\n\013)Tj 0 Tw (-)Tj 0 -1.2 TD (\t\025\023\025\021-\r\n\016\025\021)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf -0.006 Tw 0 -1.2 TD [(F)-16(igure 8.)]TJ 0 0 0 1 k /GS1 gs /T1_3 1 Tf ( Mucous membrane. Magni\233cation)Tj /Span<>> BDC ( )Tj EMC (\327)Tj /Span<>> BDC ( )Tj EMC [(40, hemato)14(xylin-)]TJ 0 Tw 0 -1.2 TD (eosin)Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\037\035\030\213\030\003\t\021\037\030\t \213\b\214\035\200)15(\255\t\213\030\027)]TJ 54.711 0 Td [(C)10(A)20(SE REPORT)]TJ /T1_4 1 Tf 25 0 0 25 505.4895 56.0378 Tm (139)Tj ET endstream endobj 974 0 obj <>stream Adobed     '$''''$25552;;;;;;;;;;   ####''',,,   ####''',,,   ####''',,,H""  c%!1AQ"2aq#B $%&'()*3456789:CDEFGHIJRSTUVWXYZbcdefghijrstuvwxyz!1AQa"q2B 3R#$%&'()*456789:CDEFGHIJSTUVWXYZbcdefghijrstuvwxyz?zvr@I]I&%yA&Ì(2;R38@̭1 0 ;\f1kX $OD94cd4p^`C0]\jUrp&{ $ҭct!" GyPO2sKH87I!WRh4*'9IYm|x*l'-iؓ n⼚ K(uv"@ɠL+sEJ:ngeWиT2r̜'u)"0E] ؁2U6b=j,lC;0򸥌@3X2EjMX*T-$j!Ђʜ#sD!t')$mmeK.#DQὪ[iUDHjtLOsХZyYrgB2e]Sb@UkHZ\ [eL`ĔotYq ! (D!U`4Qj/x*I) mpzgS6b&ɀB" .H,g3 85Q0J',$&BNg *P! U9hN,%HӈA"I3 ʇ07L_D(DӶ҆]c KKŻ"c `*V>PtОOIHE!N PUsU\Cq=-͔w5EA&9/hO;nVZ᪇6e(6]'CĵQI*"Dk_e"2g1L"wPA u*!;J m%H":_Bl*Hp H1Dže'uC]G~#=λ 9j(ieO( =YCe$ئUb#U)YHQ86KYTpB&<)4> F[$mibD{D+U6cNve"k]3YA#-1)IKM>q!kw)Ъw^g*T\Я&UI9Ě`)hP;kҷL:dSf FU2z&E5=>%Z2ڤ9bbwjwAE61{ x-aRpԇ2Ouʄ*V%A&p2&J-Pr9&<ݒ 7Ԥ* ,G( NQ?M|fW,/!SkZXF2Q @BWV]O)rNkyP#1 ހk E4@Tđ XɒPNi+7E%Jʰq(LbU(3Np!VW1-a=)Ʌ`6UETt4+tn%+bdC~iA|H|Q\TdɡQe" MՌDw0"yV4pN TJYq^y 1(v "V46m3HJGaVLur|ҫIdvpPL%Cm,ME baMEA(IfuG''9>ha\֕A\*k8ՀtZIG0T& bvKL[SbKIբu7]Щ":RX:!DVZ=0ybwN(#^n@p|C TC,R4VQ8~rp]ELq9C /2+ xb,8Ugbˆ^Ja!i476 ILJeҪ&Z֐(oh@q@/8wo;˥ .;ǖ0 TY=Mu096fk SD/nJb7BײF57Py&Wji4Kmx"Tni1⏞~}t=uYޢ@A)bX$ܓ"]cb?dySeT-wbVS[j%<')dJct麈3I$umxITmy*jmh#QBALUC E.J 0^!OpWg1-yAa!QOZ :js/) 2ΪQ7=m'vbUց"5(˓%\Yky۝IJ%XJdXsH-7v AQzLqDP)8x%+8k%2]`WB1&+{.RSA^Nq/bi 7(z#UJF,֖0XEI#D@ '̡rgɄh a6d9L '@i8IlɊZ&K!ib0r<`TD(,4"MEAm%M,X sha +SeiLHTLGIhZ` Z8(]JR2iIE&'ih\k (IBx&I<%OeT'9:G5־BXP=L+b/~h:XxPp)IkjDm9Tk5`BywFSJva= j@Аz~a0颲\+^ !IMr9#]r^u%ҠԩLh4׀5ȘV9i'dO6)1TfF)j*ua:K"$DdWTj`u=Z6nA0&e#D A@5_I] @B% N`aZc%l9F'V0 f*NQθms,c&eESt69i[*ٷu Kn6/.(F Sdn$ATn J(Ϧ@wcq` (2ʈ ]Oo  ia‹6$q؍@N\<(c1W.Qa]iԡh% Q-47 e2Mc 5T0&PqlHJ -yQ!޲Gem(䁪P(jE** 2m! ~1@$ G] M5^⑵ 3ZY92$u[J[Ll.6׹*V7'ATldHÉڎT{jI:52`ܩC4L2HnTu&V{ӽhtp2tWu!q\q ZLL\k;N"HAX6VS-N} DHObnF{KDRI% לTip$I(h):;IkkGVjPu"H QI8 Έ:*NfS:xPf*_6B8LլA> bEKf8'S'LzT 7xsكfZ`zeI<ҟ*ꆝ"awa%FbgZC] 5^SR@;m.EZK@,m1)mex+\-;Bs2MŗnǯH!կkʚԩ.ĬVd)qp{4^Ѧ pz%N ğPs+cd;LonYh<K|4G#p-q%)yP唵,Tx3GDy3\ +0^Z ׬'y ˬi^=Q\xO6F^YNPznܿY) 6#Aa <Q~" OE3 $=br6Nh2ZD!hP蝤zU3e`or;\ '* fP0?4pD)sYZdղ G %Bw!x [FWbMqL(efk IkN 5YN@ y(eJR[]ɄQ[ Z΀ +Cn:JZP,-QQe.*9FJᒜa5eo]iJ.w3,eJ N0Ԯ(j\_NЙja zS7 ."6BB%r; %$B̪,(!7&%4O Yr1DZ !RR ecfPJWN)@Uq.2Z9td $S*Sppoim*qv%5h14[ EHȁG B *.WїCSP,bQBr"ɕ EBB.*a\kL#LP.WC U}H arIS$NCq֙k[%0˔ԠI8S I*Zd86ujL"А9d$ò9f#qW`u94C$MI:b^X%+^\b^(/"ĵxl$h6)K-ݓ7HH)]ja8)XGM(8TuP)m:bB^ٍa0Ɓs^8\2CjT$BUdݛwy 6;AJh'-;&&Bq@5 {&*=HSȑjmr5"%+3 &@i,xf-c4~қ@bZky(]!ʰKv@ J](kcKT\\xb0:VRE' Fj#ʺklE3AȂ&x$Gy@tF#)$GC1Vz zvDvB k0b̢FC{#*m ZUXҕ[.!.nS2I)Ú l-ڵkEuZ[2ur!Ӭhm*d(1+mDI%U@{.-SQRd='U6( 0I$xj&ƍbM2NS !zo`g &6Sz6蘭i "Bcq``'5ST&DfEq;IґqZwRVCjcU̽@Q qjJș[ lkh"T GFz1 I 7R{&jfcLvSzWwZY q.Tvhv. rEk'L..I=HEJ954)B ^U{o\(LBt$sɵ qjp))GxQuB!)HqakB[ r.9S)ĕZ!IilBV8ءΐSI$2U 4 Ql*a:ȽT USP[)4N$fNd$Ȝ(RI$KAw zKU $D$J g k<70vjuڠS*_6Q3)TI$jPݙen2+-ba EZt0Ɵ*s=Eu렽/%jJeop 1%A=>RN?ei:($5DhQb@7; ³b1aSwі/ܝe@6 цjBp/jtRцMJЌE{A)Y_!H̽JF0G009(Pk Mk%Vmq#->t6L$*2c/ɀuSV[A$!HCbAjtECsR94.!`AP؈U ]I^n_@[^]YT-ī$֚hkI #!AMʗDĕ63N n0l- 7~#,1ZIަ|L\ k0Ԩ\(q9jD馢©.һU9ːy +SbRuZImiU0-=S)^LHhB '& .EeqmVӄZ(-c 'MM\T$6,>ʻV/,Zgyr" [HSEdKÝr2)4:BiABN"9nD0O.ЊIm;1Q I%+ci{#Ө/C{q{$IPsKo+o åHt I%[RE8 ya G94)68&EAI$BRк:KG%HI%M'2k R TARI$#ӧU֙ n Lⱴ:W H-QP5Fb7|sHnf I$Qؚ(4T9 թNMa5*%Sjg0-:Mfp,Qf"t(TU{@W6Qej54Ld( gy8QD7ծ86*@l9^x6Ѡ6dn, [Z.%oktךI.R. 90br"N)=[SF;҅v2dSs} ֋WJ@;ԪљN')đx)$$OrI$*X* AԊ+&MX}7uqLMT ~anE Pvӳ(qTTԕ($ԍF݉xE>$}1ˇI1jPmirjG8w* M5GxZ FopPWQ۳hއD)Ȣ(_b[ִ֥ &nk@2yI3\cRIU|]ܥTz'iARjS-6)zE)ဤ^"|F g2\4q1GHkDI%^ hd i9[5E|-Gpl.8 .Djj{/f!U[`niAtS"u]jTVv&EU~[KV\Ԩee7_v\EbYiꚧ]Q}oڈڂ|qBd@H'{XE*DSU -Fb͐4=9¾&YusT2\1ԩbo"To-:rKիtyP HsaV87 hXȳqKs֝%ujIcn{ + sQ)˗!zz$ö(nZ\-~3fiu3͛k J4ߓÌYnį15u(.0AP,3:t&I@8uJKnZ(WBH#X'Bw5*98D389 A)SI&WuɥU&rsZYIa|\Fũ[U<#Ȩ$I"޲;16 C`w'y]pn5.#ɘW I$!R'kC[ F{z26lzSE@{f[8y\]*Xu7M)|;:j듪g݊/^ĺ cu--E5[xGƕD012$"P'SѲha;5pp=*^ )$Hru*RmV_@ҳ-'ׅJHhPJ办oY t4 Qr$TKJM&:eA)D*;X)\:CX; Q\/QE*g7u#nzsrACVk[7DX\>a^N$*ųGe ]k}w/q]4ʘJ4RI6/FuQ Z'NFh2I= Q̽R3jv7 `*W;j0'NakLbH779L6RBŔjZE0c%u!20 $U[\1[x8=a~+tf/UF7LEvh>da($15Rm~挺`ӥ:Qf]Ri-U\ay}cM $s5V*n7qOUߩ5ӥ:Ґ%ְPTI%AS(*ԯM["%r!GQFfD[$@%Z袰9 ,,s^[qkk3 ZKSrwdܤpBTj5tITkͭ|sʽ=!IA3hE SR:/ANd^ҌxIBJIMha HҦMԝX(!`Գ]5UŽ &LI$; dTVl.ef6BR.Mgj1[$IrJd6<*QU}/*:KOvaI%>m;_N6!򓨵 b6#Ɖ$K*  hZ~}L YMjjI$W jab7aK@^컂 ue$IC3P{ʸVQi `mMQG z Qb'L*TQjѝ% ^v璥Q+*,@]dI%^:ZAIN5T ܙJJ؂@!.jJgցdI%fc_Trnmw@v.JI Ir62|&3+7 6L)U6a(j8iO@WZ6J=:cgSA6JS"(݆ZE_'ʍ 0S1+|qH #TP1rhB p\ hQ;F$vS@dto z_ fI<@'X8iwõ:Zـ:q5˰E~x?YC|nbʆW-UNihYױsZ3 X*&ORgi4g llN_VNCt$W*fbײN[\LXRǩna Ʊetp"O.'/*h.;V[y6##Jyi]~l|ܣC{cPP2#+u؇J0jB`5J޻=FP"ónYBZyYꁞF^YnP<sa3FwK{\03Tt؅1$OPM״ԸnK-}"qZ;uĭE$ 98=0C&u'sϮװs).f΢VٛrE44pիK 18rG,rt_BrlHrBCI1VRKHci_g{HK3`ߊHA .VaRskUMWӘl% qx 4)EpA/CbRņVJ|z ew׽W&uL(:~j܍bR[u &>&# Y -cV'r ;  m$`qX\M4Fٓ*XHLbF.^Kjom[0)EBxl Kɜ  ׽-he v1hkLC'YA0q1$Ɇ:G{eJԢ%W{tfrX]xSg vP@a.*)rأ}4h&RC@HCCZ#P*s̓%UJ1!jF'1*BC|xfh8#I]?O;_c{x"#cE6f\PSKa Z @㩖VFƫ7b9ϐi$I%jor Ler5$oeuF.s:\rA$Ib*E):#Ice'mnobAPLIԒI%C/LY^)z؛ 0v6^ xCڴ9>>f7N N$&P'.%i' Ӭ@`1t (-1("C.5(J2I$tR/IGcq=.Vƾ! "GU<%NךXJr:kQm9O M239A=RRI8HƉS rJj=h ]#[QsM:XF顭bȅ5]9TjXuفo4&]dLȧj"޴" *tQk3uk;z뾒-u[5 jQ\ :F4ª;q}I߻I')>! #1tNIih bt࠸l;wfPj^*gJNI$9]j,A <Ͻ,7R{aAmeWa*|uZP^ NtND\+ j$ajPW[D g֊CnXXu{lT2a'z&F<ᴻ =x5 /o,/k|\Uo,R(K9'潀;CH:S=sU.R-4I(ZwaFVئInV C 6cLkDALc^kKh0奥Z- NhAꂮ/i[ICT,ts lo8%ErQj`rqW*ano%1NR3@3ֲTeҥ-xU9ysANqGʰXʘ[h:UVU=Allnx/jw5fP. k!yG}T+1ruP7:9ƄƉ중UsK4@[ܚaܚ?/ҤӱF t $  ҎV3PuQt_O6 _*[[!q j{3bdG->33JNJf+L45\Q\L8'3B4tfpLsv!Th5ܝqPbxI:5[xEY lZKHVq*J{KE@ְiS ;,/e+払]eI$bK![(QZ(H_]ؐhhI$D3dsq"2I$.Axq6QS7 Z*!(, ۱ G(#A'q*xqI$VWU[&/H, Hr0:`'[d 3@I$Oc$-,/!Y* a$U|HO-Ɉ0.Ug#1kIA&*֫/-J:v\pYMlu|B"b˜AKD#%JN\m5* qq11R2@ uҤL C a&p"{Xač󂫠!O]Sk!3K%Ded6;egr4Ln]f\HrpXPœb k3 !/7yo(s^瞋0e tAVm U:U\o'cDWO=l1qsz-d_ee4Sb?0#uC*BQ+O4)UO0Эa%f>IRЍMWR%m @P\ɲK.8%12$K-LNk{1k EI$Ｎ,@j YG6@/;$I"hu-{fD&TpI$m{Z%:y(ifUc0'MI$yAz^L>ʲpI$Y^.5 2G RI$TqDna]H1Et4װdhcM e+8I$ 5mo*w #LJa9$I-0᠘cM'c>*;gخ2I$HDYh.!i.6o `(7 Qbv'l7t:7T6 my.") N̲T6˧nEX᫫*":(dJsaA(^ Lgez ]؃MmkQzVwAj#gWе(֧YiZ߁bqs_ʵU$.0ԉTB NFat:Нfs6"V&+sٳkW@(^UZX;(lMeL8,mfX0_wHMZ !l'@LӵAVb* mz4%{јl U6p掺L]$UkQV08Dl-=4b dmFNgU]h8`X-?Cy!!``v 7=MPs^ DVgc.D95"u@G"0~h9 shc ̍׷JNخ#n|3G&)bi.)2J%YXK18Z\Ա*H(Gl^jUӮ3#V[[4nҩvZZ$nw ȩXf|?89`$BZp&AďbV#02H{2 N+G- v(K3NJ1p8o%8*j;T|F1bT}u!J V 8!Q#Đ B,*"lQ]2]uӻi#%2I$ReeIyX( "$JS;-]c:mI$,2#i5E6 aqr)*Ia,V>I$IGQ_>ZI˹2L9'E. CI$ 'atX:tJ*Ccl8gHBI$`ZV򵮵9.m"ǂ0I(׵%nX%b79Ejtj:aLB8'H-0  oaKD9ڶm6$%2${ pŎ>Jf-rd:$YN& ( RI$w51 #e]R2S+dH5I$Nۙ .V6@ni[)!I$P BI$ e l5@{h6V^NjXi)%4$Jd|vfQvSRjj"°b^ xbq&b83xJ_n1Cjڴ!y2$J ^*\9ۉv'6^J JG]u=IB%Umo}}Q]S؂͞LۛUsŘ{I9t@K6S,ޜEPnk ӁMbkZֈ(\!pQaJ,i孜L7\rֽ|N" JA XZݓ2STKiqbȂM )FisC̞&2G`$iapyS7>*QA(" Pqrwz8jKAZgT;6-j\0]YI$ߟR#IB\,H'Z 1 B,~#]†FHIiB`Hsnb2m0 #h2,x~ki8ztWRy:s!))Uk<0K`y[ HU1v y92؅.Gc G7i'H0x91tFw{ӈ8\CxQV]죏jRB7#hâXUq|@ uZxZ-v[u"ǞDL  iտVnOɜ4i;u 8.h;C\ 3F$|7;8Y (dZjMA]\FakݐZL=aNܵLJ첌*/(qylekmT{P!qDSPp#QuN_x- ar5'CxYT [9onp&ȵi֦Ul@++hT c_$<0L֖Sf.8sUܡÔaǒ>:\[\r)P# `+!8'0q'0@u/{A9Je8Gj)G^GkSyZozX 'q-2QNsj昝km_ZD_ޙi-j侣v]'WvD].q$4CZ(OJA꪿1<妧mr%"oYWTl`E'iz/ [hE8L IaSBj<_CG(n\L TD F'`#ҢcI5Ҫ(Ml7ND'TҔ\+7lGe;lӃ Ox>~;.f+D'e^#@:#h{cf !5Aʹ+漸kn?Nj`@o L2¨9Ay5)=#惉b2`,V]r!V.A3U#r.]U,h򸂠]涞&Xv&W u{*.p Xq~9XYc(V6E<\~6?΃tw%dN|0 ʆ>+ISrNKq6K1\8x ~z7#g&`FlGW<  }~?|~[u endstream endobj 975 0 obj <>stream Adobed     '$''''$25552;;;;;;;;;;   %%#(((((#,0000,7;;;7;;;;;;;;;;   %%#(((((#,0000,7;;;7;;;;;;;;;;   %%#(((((#,0000,7;;;7;;;;;;;;;;n""   }!1AQ"a2qB# 4Rr$%&'()*356789:CDEFGHIJSTUVWXYZbcdefghijstuvwxyz!1AQa2q"Rb #$%&'()*3456789:BCDEFGHIJSTUVWXYZcdefghijrstuvwxyz?T&_3N>$3G;s0Mt0HR]!K "Bۚ2vORh[ THU/D A*<4PJ)*2;7cȤR# |,qiJ PBTT)*$5;HW fqP;`C FXWè1^d6S}Nָhv)kS4SڃH L'@F/@4)x$A4T#D*B*D) $TB*^@4]"!zhBr A(m ]U$ h)x7A<|u &J6' +۳Bt^ + 'C': 唇`8,ɡ?W}ItIG0 "vbxqJjLxUQq!Hc*Bl *B{)*EIH$H%"!xM!IHH%"@")Tzzn $ص5M=/<h46:pQD8[&9ekPvX#/PX''4Ȉ<iA0EHcE< 4BTHH#A "F)A$TH) -JDPӓ2%*變'sB,tpR'^.I_jq >`cl.ޕ0:,*l$7.!l]y19!)&u# !cSV UGh70FƂC:4Lm-)KT2 $IuI$̗t6^HE ,EB{FE31籷zhj"DAFIg:S({2LDv-WJܮB E]xCCF. N[ nG +Xh"Hb@nᒪThto~ᨧ K/KcګHelX͵3`4j9 uSUǏ5}qm}l]{ Z$@D AHC h $h#D$xM=xl;THQ`sb-vqP۝khb( M;UwUJƪE% 6 +m9OAG3aQe!ևX#JeF-uS-p N#Y[!Zj7.1]@WE_ %84E"tI$h<4e>$tv{@QҲŘmSAkt=v(eiÇ C `TtmvGxBHv h Z4 [MOZ$ N|¶= xDZ  ;J4ib؝({hAzxD$۷Nӷ@JJQDAjH>` Ea%ǂhzgYMӸ%Y^m6 RK%xdE"$I3!i o4 KcR<<2`I|wv`PR32ŗTzȰ1Oppm5hġ+qg=(:^v26#f0wKknے)YZ@x$jZf]m$1UR؟3SRI\Hn9x6Fgc]4P ]3s-xiT&[DomQ~¢TF]BfĜC=YH:i׹?_xUZkK4zcfF.6Yzk~̫Dn(JD--~cpJs"7Ƚ/6^V1"U9PbMӓ*\ᗈnpjѠ_$M&a PD4*M5+2a,[ȌVY,C,,n{6ђ[sJ!ۮ ӳ5qq2۹1*{'TeM 9&Ǫk7\Ä̴$u_r2c5U d)N(jx!q'5AceİiIE!$w(Pȩ f8{uf,qå*sf-ma]?x1ָ)Eهln<e:'ϏIzux `-q1&bye=SuLTF4.,{M6c' lU^A隕LOjS1ׂɲћ1֡g& #W;VIsc;NHxD0AtLY5ooꦱo"|{bOOK68adRE)$]CzO͔0$CW! Q A%@^M;tMt<%Nm" + TzwYmikC*IG!hi $-13 Qăe%J.6\H 4 #0)Y/$F&RIqEBלfyoQMo ZS-c\#"/f2'rw+i4&N2@4H#M8=w ڑȳ-02]O <'IZV E'fn$ N~yMCÒY zﲲYHfU;ZB3ՕӸtFZCؤq*s#V|Gls.vLơTZr.i𢕺WdPbbpi7@=tEJ7f_HkMhZ3эh s5;.N}VI * ~4憜;֟ o^iŦ4TUKj2!5TҩjrTrdpf;.ܱTNs0c`'^b:4@bBSw%\S4)憐h x?f"n03TI8N*"!c=ڮcPsh-icqZ\C$ l@ Os[˻v=Ul=d\'btNdžgˍYp;Xljk浗lK-b=u/2kb#ه{QZhS/wzq9q3c(X ?O5CChQ5uWRV8p{/;wR[S(bG )0O0C S-wsMh0 dXbaUDJTT}>I_:!>GOhlmfg)L9t Qf3\NV'h N Cv0˜FG.kcƀkLrs0#U9ܥ2Ox);CXNfJ@uS0-D $`Ct^t;#D<sH/!!ҍWo|*7S3&qZMɭR}Yf2UKIMftS$Q4@:] Çn&8lU 7{P"-t]p#Q,:To3ZGNIJ E(/TeF[BXβ0xM:bClMoFLJ)r E x%Ib)Ylq%Fl W'x|I=-iS1LT2 m 16 S/Hxa6m+:/ Q<F4usU01N}AqP0yo̶ ]e.yR4Ya,XҺ1:vh¯b*Sw@u.B'd~xEGfKd*٘Mjc5Kd$mT֓HT}`DP55{I#ղ3,7b'pA:A֑1 47,MMtM4lvf1Y&; c 7r6\;dfflBjP$C:]47ǣcadb¯fojͻ YL܏:g7(%"XpIWxjٴMjDOmCCb&2NLH0N45tJ)yuG[juD^$r+y&Ymn;Xޅ&VI px^x5Jئ*gВӵMJ"k$UH.ͨfћB.!іN4Y2'\xXm(}Ch7 ^"XxJwp« }#0ך:WUJZ3-.5Moׅ4q9nfljx<԰gjb[(4;mN9D-)X9udֽj{N:JWZ5a`WgeKӐ;h+­֗orɏaYjڞ@mL2Dֺ[٨SUc8$:Af%XD84MЫ~gidη;7W峭 !H=3J%pvhl 0VWJ5}+TobaE{+|'9c$=jsM6/ کsT3&&ǣmSO"f<$9sv% =RYy;4cm1ܜA#A )ƸBd=Ljp{m)H ADH #@ vɓy&JH Q!ѽ&K[yfwSpVra㑍KsY@a|B&l؋璻|M46( NFd[6wxbAՀ`'K$L:keps4aJkIޭxo.JKM )n1WvBeY4 2ಝ/n)沂oۭY:*Ç&;׌*<^*kojêo3׺mpTM)On֤ǣk- Z*xuUő[\ӭOlM,(\4n5LA,);y6`ȜTMݏ*WK#ζ+LD\t^gӇnjz*Iʼn ogZ&\ ԫX:'J^K#9h%D1H#۠31VLU%TqiziaSSI4t20Sh i+}6+tٝiA=tRy.$T)6iԶ70a)88W$-sƉ-c^ҏRZcT ބ(|TlOAQ4hqmuoP c ę ѪW'JͲChugIV ڥ^Q7Kg.dZ +6!ė7$ܩ;3C߽QFC@su8,ؚVs~4{ULX Ӗgm6RDCKs 2il Ҥ cv씈ĠσQRd(CyRªNH˫suڑwBk$[lj)zG,J\U+[R,ŦSPrbI`M8^d11MAQbҷ^Y83bZ"MK,b*mynlu' X\xK{hh-d>0y;nsk:zjfYKiV$-5=SwCũol4Pk'$?׎qSDi.y#pfÒI)J9oH57kXv5޻^>';mm+;.٥˹pV %5 |F5su:q=)[#wZ\zhIufw 8ۑR`Cp#%5M\:\<ш '3tEy `MOaU H6#-.s8xuRiOdiщMQU9r֡crzqiTbSU#^$:N8FRLW"N1해VUa]taKYJY=HpIKSNS=t8tUsvKq˶$yM dcE(}KmTt]! Aڎr۸Iԃ ZƂ\]*ƫtgktrk)٭L/eQEeJlŦG;#K7(0sOLLT]RMSK3ƦviSR&mb^êUq\ns[wڿnQO jXn,j.ɗ\O5`ь{6maՔ=.F;"cxbb+ ٝǘŽomޖq9wO cɱt锌 @yx: 8jvCвl@Wwk?#j KRsRZ֭A..kb),^̘jx݊i10LFWlTYE[J!J;ӊ9])PCvHWCYd "(%MexI@(蘌3T(@e$W&+t]rV.d\ۨ }[)SNJR٦!<$fx4C(ndQ7 cJ62h1M-ԣ9P SSi%E;N ?f<|Ud:5ޝcWdOǔΜ(2VRyuB|h6l׺TVf.ۂ,Wb)ŪhOs6*.jUz^cnjRkv -RE VH\etm+6p*{P}܎ N66%Æ`Nbpc" $_RU{x-<^kn۪5eQtW\\O9N8usvOyxw 6 \!D8_1Um2 D@p<> K&39C 9>ye u)yJ[ۈQ.&aĦ[2X)#^vio E%(tgJ14ggqoWs^PBȖ:ǣIr"V%_ճ1Nw0${ClA JWtCŌ45;лRPԀz1؈dLm7i]BqhpⴸW;o.8`#{pٔmw%^+O,vLYF5v3 3x'O)'A杜4<#cMM2}V̘X4%MN(]*TvOs0ïfS/5HbԶS'-qcW4Ӛw'ي;6.,^WO'chm>Nx~e oT\/h:(rVbᥩXwp4UL*'*TMْ˞PeH,#kQU7zf5i?^ Jיb3LU^)<\Pqm$@1-nw;˱*BE:F2Rv \˅8w fvP<ξ(WMX 5㵆dvw4nVY4̖&M+*nBO s^Qz&|AO7;uh^jO Ӝ)FUON٢ԃ.`ڏ:%y<#\TTMvAb:Y.É+gi*nhpۀ);=uA4Q;tۦ<өRY舼tԹ1-**e5R{]DWP oiRY;m$R\\NKFSjhO>-UӳyFReXt*U4IXŋZUR#LmuB;4A}ddhpզdvY0Sso]ka%<1@IiqX,GrnAKeҡBnMoSBv?46w>D 6&Q- 8PkWSi3wm,)u=Hgdf0I:^+MZQKMYiV6aS(4B= tjҔWM [RˣjѦd5q& T/\ih=ٓ+4_`fpxT%EU_Am#0E 0A0c?#7E8SŹs\Ɔ7(Ij;螧EXJ5+ģk&F5*>53aKڔ}eAdcBẉtf$J \uxO4ܕU9mĥSSK-7rVѽFv,5 j ,OYO}ù$ V;a=_ys˺Fu$L I/hp0BzxX?~=PHW6cBz~]tQg$,Ԣ !MM|q2 NHF39W9_Dtz\ٮkpya@=h@qunds=HҘ1cpy#Gw?Xh|XeṔʹד̸-3Q-a̘24ˁ-<[s-:Y3[4zTTnz8εts6ND ni9_Zxɻ]TdJ5pTmmuT4 czI| i.:)țYB#-taYO]XԻ4e\sVԑhr\zD;1ppiRQg9%U3Leaťvr׈U舞v;M(a}Ѵj7IO$fU`ԯUԢMu<̫cncjdm t$&K";GzohůmV%Ul`ġg-A,[y*vX ϳ$SGL^渝(M3U)^UtkaV*)q TW\dͥw JSejΠ$B@܊zhpkڬ +Mh\t˖$T𵴕(/{k'W3mS=$ڜ$'=Asn2ApqJ %9C6 o~fgRG{lUJz)N;{%̸tꮧ5n؈@p馎d&ʚmժ$@QViӈ#pyTnlbt*+tU+~ŸIcGVeWDM1oS3ʔ\ˉBQU` Uf236ަA>!A<ApT礌aDY^HrfTyW0NJEx'<¾t] ̶0xYF>u9,T݊i< ;;T3R}4烸=(1 s]Ջ)ħ\a2<c##[.R7[ ǏX&L֭<|`Jtf' L܀xwzL]d*Sa=MX5[i2M@edM.0a:[W Ѭy& cюr*qk!k`ک+C3Sxi+*z9뼵 hn7wqi ZFd,8yaŤlB"bNaE 1^ ykTEk]ה٧SH٫]Y] KMo>sHu=3N5f jM'L29XDc{F)5,][;*3#B2Tg)\)ҞũdݖWC%Ǫ&R˳ 81\z)poeuԩIjE/ث]kCڒ8ikZp(Is3UT{^5hcf*CD#IrGf:'T^4DR1SKėaK .F@6@;#8Gey I)YXf&zUJmĩJe ;!ƶߞiKMASKSpIAEeYMp.2Ef6]ס=WcM. WJٮ6LBIm SO,qRڃfLZJN$:c3;H{\I(KdOQrS.{3x/ř$QL*iVKϏJ{& SKt-G2LTl^Ĵ0̗4ULe^5ZI73#UlԳEAة./:бiADP i`7sEV PiCG7l;kĪ͘0Mt0)XFs<8d4WfŗAfŠjsw!bzwSyZ#ac; Y$WW51R%s?tmdsbW8̜φm|4N6E꥽ ;IC2x|!dϦU;WYY5_~yo]5ȡ%#mħ`Z4SE%44xZ$C$iyoxQ`)% ASG4t8*ĉ0 X(aFf-NMdyڙQ`NAΈ16%XCfe߄4!H'E"gVdG12k VJ-4􍺰y%ROS/= \d9w tGM%ݭ}cҌdX.\16hۍʼJNO:LJY=s$.Mr1WC68;E]UG`&l lTeՇFqWaxoUSMFɉh 6f'0%*n )lgq^Sw 0>Ē8nT.`'ӴMБ.2d1_I<7X+pYxu*M_3aSfCcE"ƺ4}y39a;(k uS l vM={#s RNmQ\kz1JN =nΨڢt'BϛNRjZ\&2ŮÆ%1RH FKAe5 擻^S5${*#72s:U5 = 4v'n46TRRʣ<ӳfOD K%vJSU[ kUJ[.78w"MpbMӑj^'vytW5NCc ]ъWn>$O>DJ5WkJ%pE4̝(K:HAF Ndg8;'MR1D0em !2Pz>]շV'Yl8/U Z(@,8idPIi0/!B:0Ҽi{6*libj.A&undmʝ(B2͘-L|fh4iNHz64NGnkKXư|O4B#-RW=%$iJջjO{px-n.V2*KOن۩e(MZMڗU*O$"ΤK"5e }E'VqfsKlrCt4,c1x=4!{_4R;xT{K-U̘[ZSq2.h© _Tr;jW]xXKU5#F7+=Uct+K6Īz;jsM8ؔцvSex9y[[ \8#kp!kvo RDK =$͍OhH%Nv3DE}4Gb^Ib KKjdjùIw!xF U.x%U=."iU!bQ&pXG7*@j􋱈xulG[Fgrx(Ꟙ vS~0̨zDEԛ u@JAxش:JY'~Jm̱8zve$Kѵ푡6ЄTNlIwZZקvG6UE|ыU94&4)W&Ϣ $]KE)UytNL47䙖,3MI3B]mh=)Rbkc0ȱnFZqKDLВ..Tؘg N H4]s>Tɬ:wI;g@Gi<73h igli٨éet@q9[ sq;7T({뗉%أ&wl1姴y fDݴ<|,$qPzS4` 4+< h&%GR p^KN{hVkURa]wS1E.Qű+Sral4|j l[>R<ƉPj[DϙiƦL%ژme+fa5mTڈnIOv:f"'!]|g9TӂΌuUϏ859V+1٥}k΁4*&,1=wV3<48T/3- v IJkIɲTӒ;KB8t+b*ꢫd ĦvG4C/9<D{MyxbFUn$魭<¯zk|)bv΋1Do9}4 jކX66k(ۦjh mSؔ>1M^s`e&6(Pns5x;gL+[uSyL.oeE47@l5TX27:ƍT[$9ƄjćzN\f 5Cڮ]L& tiN;mkv)d]V2UUY\ĕJxz5RuM]UE6L@tvN5;a%q 9poM'^M-ëD>ψ *[|͊5ɈR4.vX#ihd%UQ-y.rRmnzM8muJ5uԣSom6Raڥ%NE|#쵰9c"@Y[ ٘%n%Z<Շ 5oXs6뇋CҺ9zެTӊ(*qpN.X`(>)eDՃQ4GZ93)29Ƹ%Wr#U4QGaOnL C`IDZ-??"eg1# -"fpT^C<V4laOW<`i4xfvN|kyf49Aب:9u-Adb1'FgXΗFyI(hɲvɢ(_4E%y7XS"<K"c/<\2SՓ7+od-DN \p  ЂsZ툤`d udUBp_´-HBH^%XjrN2 O;bN1!W)*s^Cf0Ns)&otAݐYAv-NJePl̹O(\3a=R1$gê )oQߚtCOxFtZbs%qUf?3,= d:MJ0"ڣݼצp{@=LT=ݨk@*\ZuuH7 aGOZ.ŝʲX{:iCkSUI*v&'Vi:TF|^ezՎNb:O[ZX3 UL.u)yz:╅i6ZT#qj+WbҚADU&OOe51;$Էl,i\ ennkj;:@/:*`)<)\Nی;t(ízPݠ*$5$'` ΖBe Զgo”:2Z7TW47T+fl\6V W3WVG:U#A+-0%y;lAcLSU+q8Od8]ZZtBA{||dam#^ qV"鈈3vSbh5I.['l8Dˋ_rJUmsE[w=\1Bw5^#ԛ4lFp:×4u&"'/*RVP#Rjcmvc*ZU%l,5.;pXn qm6nGܤ'=N;z7flKkPDa6fIkTmsu5WEqRk)ApNAl5\2;$:% 5bxyJ EfױyZ!̸kՓ.O9ZkwmShׇ8F7"K{n曐^j{'/nIxnP:Zա+R̸*jcո Sa Pj844%YJz-I#[ ڰ6!R 7E#;^E)ѵ9AHh,źnfm;{gUgzF-Xt%8U=R6ZN @I)Zw"sMe* -+7"=^QTtֹs:MKj246PbQҶR] UѴe9« jjٞ"1 ywEVڦɄ[M.I"J$dIPD*MZ(2E$+3(i1|alԖhn;#taUɊ)T ZpUԭ&Uj'6蚎ǷRBڮcVKCԖN G,lMvʥ%o7`,zNtjUTi7< ׺Is˴^8.0' ۱ o|ni(mTy$])8W"1({&; 8EZA^IfŰ܇D0$D`_yJi2p x]N$ nH+҄a0DX0 @ʈgQK6#քZc ÚP0=[p6"ġTZpI{sJD#ǂ摈 Q`i1$$+m0)fŪS\!p-a69(}VE3cӋBi掟٥$%ڔcW2Xs'5avҫs蚜̵M0<.I5QlU.%g N+5}#*u^g6\܍uRQ̚]spx4 Md S]ܳtK6U1 ] ަO0I)&5;un^rI v=,f\:N#S :+ͼ<>-9+DPi" #qѠE7ٟa !fD,bīej4<5Ty12\%;MѰ]7%}t'Jm]:ު]3G5j/+lhf:Հ|#Z$/vR+E܊Ҝ;##ڈ3(xeMaӴ"pnaw4xU(œ9hi#iq$8/Zڢ}IT5*E@A>U{x*0åCYw&6sDaSwQ:z)"Q;U6NcQUR5ՑN@n]wSc[k=`ѯdkaEXn&ۍ6jԝ<=fy! yyK^3׬da\+rY:UkV*ڭS Ġ@q*Tհ= ãzi=.~bU5S/2mFݒ+yĩv|C1KNsB($-:iTM <z"Jux4f[T5RňMU}뗇ҥgR;!uചsrWQpx,`6Jб&%jD{hҩO,o*̸صcU59qΔ = |C!T`<4+jۄnii! xDmKR/NHֿ4R5Mh!t<HF`'%OJS@Zag&xN(%Mh&gihM0 8e~JHuQ{ơbu G+&78) K%I;#S28V(28ۖ,FDˇ(Q:,_X2r30H~&wG@O|˔t rS"sˤ;.-_S͚LAŝKwdqԢͅgaa{G:Wئ:+i >nܯwAJ69ŧu<"$ԍvR:z )N8rVj*#fq͘U`W6F8Y4]sV ǥez*ފt8veN3$#A( HfO*kɒ,6f-V:NbG4Ұ9v-+-%x0SFD`Mेz:#ӓts}qӮU#tG0 {9^(~M输'a.qadյR }fSs8.\hJd|:{  {T糪F7s.7*qXLiQL8¨|+]=<׸[61a%1 6*58aʺZļndX*ԩ+*⤔td18:tx?3=z"Uu8ɐQ'On( ֆ7KXD9I% Y4+]B)rDɍ ƕL[HA어}eb,3^:p;fŚjngÔgg3l-pnޓ!s*Hg /[7itҚ|jb!R7o1/4'4zf^b2}H#dNeyIf {Wy*UUY\iee hI<܌Lʥ"M롧KUB. v+2UFj)q\5N1چZL:m,1&jn"8\$hb(MRcVKX[IfENɷӮ ʍ>kgKecjޙ4jtWGh-`1I2Rs0\ H H(4(Riۧ!EQ#())I%ѣ xpk,OFх'jh -!JweT* e-7Jm5]Vj難2c_= W OS_S7? O Jk1m#bnv%Ԁ Y{%n r8\y(+A=ͼ̰Yqq,a:^;tg+24WiWb0[;;SZȵo|-E敷KTk'8NmY5%?G$a=>Ыf Ӹ_<r:7FT  ":z6p!dUL*\TTU.%*U]K1Ft:j1Ǣ:TOqͼO4QyVSy < PZas7Ȭ*n erljCRD۳K1|TjLL7Kdv5ISVVTc.:R,RA>5 Y @șjR A[/E79s\RI)<986 51 S孠iH{Μ. ;A^eX؏&n.i12͵a˦}Y4Lv Zt`VފK:7Jj(JstOjIV0R旱[JW|']VY XDaWX+TkHV虹%=̳:\LjyUSYnzk"`bKjP5\mk6Zx'"lcVsL4ϐQPJI6 0C)SW0֒vF%MӏMBANۗ)%QFִhԥLpF6z4a%:Z<Eķ.Z+0U195 ([f a$J"9[%(5HK H hwHH tXLuDeQ2*@%bq]P'j,hz)x7AE:.m`R=U'*@5Q%wzu%)N`baE86ۈ]CV .HSFd;%$oTǂ}`\nVIIU`׹}O4fTՁ^9#Ou,kƧi+~uKg8hTFn)aX ];/ˏYoLw e/4`U[TMZxXmIN]NaU[X(HJ$kmD()nt8g\F6l'~UĆB[jTWy.F2exJy`bяGc<^3E|ZU[/Y[\8DotDy'bg'û+B9܆*Uo͜O4ӝK9]hGOG5ڵPb^tt&b#M#AN ZU]!ѳTxh tjm7j4>ڴ,*{QU4NGrh檰 ]7Q;]A6pf4ZpkWATVl,Ҏ,~㞞⪹ڤD+3: ]lإ0d] yTi:Pb'c::7lǕ'c*x\DlW`k'ex,~v-o/"`/vQEagd͕+Y{x-6v54ySMofy͸*Pksex:j9uGCy\I{Sbfmia;AShCzAKzmxRR )4RBR#ѢAIHz֔$ dH [1)`+a~٠OC̒ۓ - $-{ t#h\pK_:\2DIdWNHY&7h”d=6pxDN)F`\t;9|4n``y1 Lڭljm6vIO LcpȖ [/nUڲ4PlҶG< :Ƌ S0Z`k-(9U\ω*;cC DžU8S4U5u,*V8H&t. |앋^-V8R I˼4sipt5RpӳE{# iiF-ES}&͠*hi[tRtcqU/hW)G͝aKZu]T]s/6Q1N-Jo2a_^qW4p 8Lkdh]<(+ؐZ[퓸΋}`^fy Ys)(3KuM.jJ7nasٺt59i9YT\O AUaq6Gzkm2̛ j4C:&pBIFG||WTz W \jIAs ={[xw[nhjq銔Thk+u1QQ}js<#l׸Pe&E0ma`s]ب٧u XO2dbvwA#jO Z?1 % V{UKCV ,ت9lQy>*Jv0ST*IX2,7sq w's%>Ư1+u8HNf.# uԲY#bC$d'F,M2G$HhHtm)r)%MmHobLs: bQZ+{t7(UvgRG60dgfmqGRÁ6*) ȏ29CZώn5^w/%tGb#\Uaژ\9RZoK[ǞR-%ϲ2J h${"ȭ$A=.)4")ӿx E,4A$x%$)<rc i9d9F\:ء.#[g'z&#p8l&c#2ԩ#ŶWFGH^:'7ybSNhj:1Fx5;UV@!TkPv2}ܵWam4m*γIsYBRKǒA Ռ%ʹ3x45"kiT (Ie<6)ty#AIqrW01sN.=NZq#2sJ#cDr7݅/h 3ZD,TV*])V50iEJQ͜qiڡeH1BF^T =d!@૆@(5xuma>FlkGMt-lܫ#IAcy錂1,`(߸pTxJs{`v]ۮ[ͳi͙U.|62,s)1Cқ+uM2z0x%B""Q#S&5?*jH(UA`mږIel)1dvaB C p ccr2o716TjQV7UJL a7[;;EIα,XdF[էMTxaFP$E@=!'6&Ns$FTT3ad=!8kEFDJnGSIJ%31ټL6K z е(lRc:+MVl%Q'|,ԑg:AB#*Gb1 R5(xv3[NVcĊNa糺G>TXEcU6nFziB$/z.jUJ9Sb$dFoUrѹ-=WThP7E>{ʪJܾ4P:2v kB HɋCb D %n'*KA Lb mO&#"b2ҩ0]|B(0 c6dh]@ӷ|NXFV8lj[MkjSfvuk*4a~4*OPJiJ$n{ĉ" [᪰mJfXj2CNF+;dmph>`hA^)%.GPM4-d:F,W2*Y(-Y ɞ2c1\SyY O YPTGQ`8T<Ґ Z(Α# +1xSER\ʽWfkB) <]QOa^; 3\hx*\UJV"yu"fPhڗ NijT*u1:O @$RW%E=RBp|Zg]0Ub3jtE3bvOs,u)LϋVjYJI#DAH-to1] -MNʥ'|bСξ8,Juω+O[PYe-!'G"<={׋s7J(tTL64U];,惺U hAK)x{ 4h0 \ 'F%Xu*p֤`%0'C˸\ 4 xXX< tkqq[ IkfÊ#1*itʔrc͜*qVwB8K@хKR+p\@2Z*;:ٻUjlR+rj(T]4Qg$iNĻuۭZ3a(W7W7iigdb|"} ai#J"s;Č³JIhk*l5D,<`da2Ҟ<$Ds*RѬ@E#BJkO$x@)`aI7vQ/@fh@>D,$(lˠy"I()IJ"R /$nu(N=Gy=@3eӈ<*~hÈr٫ϪokwEuR9v װ\59dO6;IK Νp!ިKagN{F҇fl0#nGzv{18=q#Cy&@X-7 e$v@NT\,/$n˸P+^kטZlTLgGCohS8nk\/bG6᪛s*<^]O")ûza/TX YQ\doohij<̲$l:iצO^M|U7],p%[߽3î3}GjJK=sjq",!%GX :k^q8U۩t!ϘYTy| ~e)uL\&ykR|6v_+L N)BWAx/z)0QNFTGq> %LRo^b抖`ͺD Ķ9@PIј?.ŧ_dd& hp6G$$LIeO5`34iL֞`l㥼x{$f \dy>]uª9eO. JMVǂh >@OPj6k抜l3rD hR4 "TO@"iFΩ,uN']&RײH 32Ae5hHмvɹ 0pe:vq8L*T$( +afCxJ%SDYUtL=vm2nNg$xm:(M;q6ɪRU Mpx$Ԉ`R@qaE OdTJ=2lħ6ePו*Tdj 0xehEo(k`DV$<Y $vwI)CRI)E!xJ)$l1Gi,CƎby)]iZ|LJEb#̒jO$3 & 䕅;T(cYmݩҞ BYNjl){Dy)+6`'>0<٢s*ʙ- ٍ^u+#_L<#+5h>En<1D)扬JMSg 4a;V4\v71BԾ0Uv7(/`^^ ^7mz1;2{Ft]6k=JMd˽08|!sW$` + &^NiۚSHleEMPR˞ٜ~ ]~4*P*$߿승c{K];,eKGK5V !P"%e"ui$ * :$Sd//*ѣ^9G$`hҶ\tLN.$fnT3K2⏫(IPyCh,!I6x{$H(kؤ@)&ȱ$H!?QJ~0BK"REXtK2K&y3r<h$gpy-Nt3$ ,ȭ(3hHrM dƻT+S 1Oo&MoFNYS2RUqc:h<{`4rr>="͓ތxj6mKyE7}jqm2 z&G=_<ɡ* z!+BA^$hQ@"I+ AkLO+FMnNTF[=H'%l^kkZԸwӵJX Mrg<%PMTD F <<j<)AM " R<q Gեz,VQd!U1qpqE2%U{; 8[=XlTBǙ14< G%gIJ0%]i`pN׋)$dt8dPHGi Hr2Snz@)G8($N^qL>LK ~x=0'n4dko[.q7*]6 e|tѰAd9I"Qif:SeizyE8Kz<0xXFserT|#3ȸYӋ`l,w*YTކ 4Pe^(@$ Pt): g"J 4-^Gr5\R/8ɡ,8Jpl\f]i-YlNa≮ >RXW}:0IX2o4UJm0g4]S9tdm)Igg!_1jTpwfĈ0` |j${> (n bvs17%}i&'=siFS:4H\CdSS4W4}hw{;[\ivYϘjW̔Ruu4AÇt:g4.ٜٴSյ).|A),Z h1\tN$A;BJ"঄H(,- J G*Ѥ#H"/O4A(AzzI- 2%H=( X2$xZ4,NITdn㶶jI2{oUp8jbw X<Q>L)&jHhwnő jqʹ/$"4ܒ8M}ZOқܤJ@N6**U& *i$ )Y`v[SvYEE{'C'M1D}M\Wm\p"Ж5FdpVv*MqщQ!a7bmN" ;+3=M(͍X:ܴ endstream endobj 976 0 obj <>stream Adobed     '$''''$25552;;;;;;;;;;   ####''',,,   ####''',,,   ####''',,,C""   w!1A"Qa2q#3BR $5r%&'()*46789:CDEFGHIJSTUVWXYZbcdefghijstuvwxyz_%!1AQaq"2#CRb $%&'()*3456789:BDEFGHIJSTUVWXYZcdefghijrstuvwxyz?kb&_ wCK/6$X&\n~`[x+4uHXvRrUOCf[98:Y:L2NtƑ[hx;.>:"9lJAW8yelwz`,] 5 ơMy'N"VI7; \ ټj5 7Iֹ$mA6޽9ol׌N6Ƙ݈uHb޳9j"7^'(-9#5t]U#ޢ~yvJ{p3u4m ׯQ#ϖvf##aϥliȒD];#}:ytuڈĬeym毥!bX,½70$[I䅑P"3~-#Ak@PPĂUrMwt_јxU(WV+ϜWW rU[2d;0Q٢c;\SLPXxsg௸̖GuIIBچHxlZe׳I޺w@˹,4;``}hgo~ aɀď 3بYPmCj\0HEsSe &Y-ŀak`s0IJ"vgHI0q0h-/# ]fX҄M~$G\P.״ A SWp0߽>6(ͩ #4{8[8n5t/! k)WҦ=>o]}흷#֡b"9قυYW%Y" A݀έE[i'y]dv%$NXy+h h5ԒI O8M2l0Q>Î[[Yn̪}fX/6KaW9Q&<8])#b;pX53 9޵1όˑhQ,vK>2"h"JZ>Fy"X#!4Toeӡr@ p9 ;{h\sQY>޼a?Pp {Dg>m&(6Ҕ>5(9JE٢@줐T{t5ynL}gsN.Vfno׌i p3&F#-HU/ ',~s_ -!ໟM&{?XTsVA崻!%jWদ] UΤ#ّ2`bJf.w$wܩc5ލZi3 sn* w@~Z Nk:tW" [Hll(*`BՍ`m/K@Rֶa;B 눖 _T$rXoy*<7 *\y$M& +v=L49YL9`y0]F(bdc[26gŸ['8e=O'0,q@Ur@$|=WݬvP NO v]H+etedA9mM. Aܓ"7Hf{) }}Y[R k&Iuiʻ4dj-ǘ6*a•#><%NVm<֌ ,̐ߤnHrV(c w0$@FBHH?mTf$U,c f]~F^% >~@%L0aS[H%djdž6#%T':i1i(wUg),U]m (ޜ۾519灶v.H8cze=|vtUCj*Qk:\ :N34s:sj3NՔLT\[KY۩DG*!X]V@dFlrgR!J}"^m;VT`=١PFŕqfxu~XcO n"*dN``#T2џl{1Xڒܛ$ש65u{pƁ<05Ղ09=~;>G\pw3xG Pnb :ʜ%{XSWyvpRRNqO4u? - Av.m=65%I8O-8ER9I-Y"da|}̺*;mC$1 6aZ7}{@wzi8b;Tm[ٟ [?1]w H] H8{=6|R0ᖰO@DžQ'LZH1'჈D7#Sp̍7pxoI߆R 0:su`}vG{t 6P)}).i6= AZ|42l.3#;rVIkYef?BlU}M>l<3oj*ݹrLsL 6c'P c#_wNZeV22htW`r㮂1,izTy忶mvZ Oj{Vt̠|y⾅[c d|p+R%E_QO'#7h 8Em>K.*zKN IJɡ0GCDTX){RX .Tl7%mή#1R)9;g,%}KDڀd Jin^ԤyczN(żRHV2qn(%YYQt$ׇͨ:#,7KFY i#ۏ^KpLqŌ $7vvy#ab6Ŀ=n*F&_,F)M>s\,vRC.6OE.vF`s}vi)/KxzճJVEUF2Fr:-oyrMGErwA=ՁqￕUsHZIB[pW=H8dY+7wY>D VFl 1#q|ٖuڷyYzw]k`2p @qQQ"ĠGXΩY#&FT:pUIu3ISB6 !|<Ү4}2Iۥ}P$=ϝVpy;klakiJJڮ`15'bsPi0'?1CDn]ԪrtxxLsY@-өuKuf+eԺZe|S@!ʩx3 ; öB1#ૌƦkalt 6_R|)tqy=ʯ@LE[Hdm`ṉuqް=jX{RR{ǖث!i brG۵v[p}'eՉڶ:r쪮bPǓbW}WMU]@g1Rq,YHJsyKewZɘRjku]sgSʓ\2ot[' UJg2Ib|=MkGΉe-I,Xs#P\J̫2(ų|jK"4pϘ?=G6eA%T|0FE`K.gqaXƦ>[Uer 4jFN:9IR&mDy dwnOqJRQJ-_5_vgj9gwm27FoQd# $Z p[8't F14[nI>^le%ԍ (e·2_k9H`C* 9 W^緒;e`؉mar>:!Tː?-$wpjRZS̅錜bm%)21psr4HH"rD-b I`՝j?-E=Z(mq582tNA!j/k!;ȍRQ[&ڷӁ˼y.ۨ@L'b|a$Ͻ1y%(a@!Nw[[INt yQ>r6*TpA$hP3RkKOz[ʽ|?Q a0Zي[q) ˣ&i]X.X6'N9ն7KsrrKoeUϜm+U݀ ^C܌U,ozW ٵRiRQe=Ӹ'GoJ⍰@U8mfls0vZ -Q#SP\JbAʆ>#V}aT"ČFuK4I.*s3ҲԺR}FT\i>T@/Vv#ڥcŽѪ't$PTIizj Fѡor\pWiRfB1O*ր{ps5e˘t>5T3$[P'ǝY5}lߍ $]R'~YVdP 4rrkydI@#mc6u,ٶu{ytZEU@a|v5 QvNPFd(gs]AV2u`NckZ]dWFUޭ3vZRqNuUh\Ίu TTY*ߟuޑڕ6+F[uXT˗= +U;lj WHӐyYq۶v\|mc穕D IU37or떲+rQzmiM ER<&+,@1(O3FOj"q&+r2zQP! :9LIe]u5ĥˆ>\+'e 3Ղ"$o;})imIR29~Ub {i%~2 T۴H;gaOmt9^7,,^Mے{/jiȥ{R I`sxQ1"._04(|];9۴`°={T$^\j,+G@CFpGF^.,wQՂڸ,> wlo/!{+0m;K:-&K5wgr֧NtpwN"%]2Xs?^ؼZvP3:&׺rq'bTmu'n m>}q¢=(G!+#>9cq֞-=&}lTC1xϿ3讆IoOހp& V&lP3Zo瑊u@cj[we4 qjK)*˛ ܭtɪ}G Ƥ5nQT=I>\t9Z[EuoYM<< wF 2Oy7ڪoya_|@{j及Óqr' m0׏}tPӺr +-,[^g w,g>`D @!z\gUԏlќ0ӎ<Mg)(Oe` _}^'#"A֠Bv۝Uk"{m!F6<~$d$ GX\v\v`1ᜌbj[~ qӆA8FhiF`\"|q}*I)'9Y-`MjO_I\{da+C̃ە%.ڝu EIQ , 2GΡ<:e;u+rW`M8;OH*F9g2C2 n=Pz$E}Yhx:=u\p֮<ըƻא_-HÇedC}* b:HpDq\*l9T:O H8J@9Ӻ(r|",˭<踒Mz&(y\zRR[N{[,2<ɢ&RoDѝ#'&v'IzU}o} tEՍ^fE.t$ﰮIrX.̌ v]I:n =OʫmIZaQB/Yh;Lcr]=*s!qc/^w|HCaT8<GKś3z_\ p+} {4IٮGH%/&0-t$c+CĸiTKH(y.*Q Y8xHKIL yiZh'Hn\g7RpApv)çkfw'}At Ժ'm eY\ ~7CO7ʽp-c %:ed}#fSNjNya akŴgRL@߳ 7 |>rP-Ly6{B# `:9%$@4q7) '\v&G#9=с.2<(mC򦩦6~,ui'8vW" m@j~N$RSt=6NӭĦ0ah>!crea:ydrUQR=(ȚtHW=>yJ&9ΐĒqW']uypl'-㜸kw^_A{cZ鏰j&ݤ;5JeV" {m,$Ub65i?pd/K.>fKKFwKKu,~n]apW#gq>J"uT8L:ndf+TGSDGioi=:'|I$qw,7~67$l.9g']9V놋<$">ͪ41Lj@|yT}`0s {Idx#\9<Eo͘y܎fINӲTĴO**{wJԝ\jPU6UQ؃jUvIW;,m7u9!u1>޵O~ˬ2xǰTFBE ;mЫsnӈ&*AO9%j]~]ۉ;Jm%o{]s$ -JXasy5ssr7\ 2@s퓌oQ=MUF]_Icq_*IyJq+vѣsHV7H]k뜝qHЭ1cuWW7 ۆF]6r1U} [iޯD=RW&{0=׊RAnDg|&Xrךp\ds8ڷ5䗉Yr Uxwjy&X0k\aȝ'g F5B0=rMl1Mn:N9 P A﯈UY^ Η}%*ǂpoK9\q Ƿݷ9|B<ѕ#NO-Dzc(IeTi/%S/vP$*z^`$pXҨ-3Շv/w+")Cg4/'E x=+]L\eh۞!d ^29{y"=T/b(&»|a򊣥KXM-IEd΢Ff>6 Tb99ʩ'u 2U,2ALS[ -B0]ڢ!mc#<֪CXE1 .s;vrMIv q;mE)q6%ӡpW^Āsr^Ln; pT* 0†o 3 d)"T/,+/c,|6SqBRK67$,zcEŜ F|I1 Fά̉.q]Pմi`%#s2<|VHh$,=yUۉf$.WP(A1:2k')Z)i5G/4TI\ meiO]-p[wkhQ [T UMi$C}y0M$p4es0&lzb NLN"*nhp++fY=sRi2$ø#R<@oWMiRi-4.BgqΧ8ݬ^H{'}Goii3cb6zK'ok%YSߖYd-Pwiԧ^ :,byV1*#8铽JY^JM.ʀWqiktK@)@U8m1,.е$2n#l۫TdgPl҅* K~ BnV rsDiBkVaycpj;HE,ӏx2ڗ)l`c|TjRX\%Nޟyr'q{K=e|TՈN0%Tw\%Zp02GO jb7Dcyέ ܚ -E`v×\PR9n% E4۪u-2MW vJcU$lo@5i;ݰ&mD I8<,GepO}Lx*2lT ǀfpnRYۄ$NusM͊[fea٦\:;;HI;O<ȧ :^=sۨZf:tve &撋}Nm-31% nE|@"miqzұjRyZ2`p>_?K4;(Uɹ"034JY\䝱/؞4p$:w* ك!DCdꑊTM \uǮFq?-VX]HlAk98,7+)p 0Nv"2YUI5md`qd4ƱFF=)pX[C2$} ,Ѳ0lwwۯpE4@'-gΤXNMuJ|Z(( [gQm^ ʡO{ U˒',Txt%j! lzc adkkzc F,4g0qd[Ev8`ږE!UBw`xPovEBs=* )h@ %Y> :S.Pi| R;jz3DQg~G.bQk+O( dD2\F;07<>Bxl&IGOx}KD[vS2"c=qϦۍkm2{OaEq+]}RYsu[h{Xp>TQIĮJt*ł1I!PWrH*uɯ 9n$Vu)K ${Nߖ]QٜLgj FJ;g#j.4稶똷Y5<<;#S>D8+t;NFz$xLe{g["'$~x>vqr~ZNvb>ZG,gdʀ/{;| 292DQySэXjybȬJkƾ;xҸ>[]~@8*a={d-F~=X2 {خa>Ij/ 1Q&esv$˨`a˟_`Y[1}cۓQTul劎|{T lt̓\ Dn7 Z32a8ץ@Y˙3lfs*+AV8aSkfvZ U'1,xWfFsxcjC`=V k\D;R'@8UO,1)8#m#.s9'䫙hPGRN>q"NYZ!JU*YP7P&~4y?Qg$JdΤMn&#'̤vzsF8뎊1Rwy\}nGQ)R>QbJ`NTd|qyϻ'Meh/<]7d&Lz#" 7<>c긄iMG!A*ٮmxIEgi=:ըnUn:gm*88}œZ3N" 63ڡ%ű:\#YX[K[]pVVj¸F TҖpTfnnr`<(VuvΡkYŵZsvpn!)@X`=~x9b?U--B!cu8Q-üR w'H|+Мf sq{/Ժd]pqnܚ$MoF쎴k۸uw Tq5mZBaW;IlX,k%ͶHQiӕ7g`0S8q B:bp3Pw݌Q{\XC ;xƜ>!kr5"PM- ]oʄ6EZ`uI`1Y{J|# uvSL*8Ac&Y4͎ɘ ~bf4Q(\.W>Uw2}4O'}F@Jioy7@r'Jjr73p-Ck2rQ• C1j$P:?û/H !^ |*մT˺>1Np=hg@ҭH%*f\rFӵu[&˶=6+#*1S8՟Xвe'Oc 9|T,NMJ ΢@U |mMAOE|6IGkJ]4o(۽#b*@ev`pA=@9%n&v29|4jFLJf㍳vRggG yPwyBV$s<2k:NX<W'lVhtvzu{V|`wS,u\3}ҠSÿ@!@bFY#j)،br23ҬĪrX1o:Zm7(cRv#9=&Gr#^X5c e#۹)UOdT uyWu| $#mQy9gI>XoBѮ 1A2Q`d |58`FFI T0ڵ9oi2=-y@.l 9+b뱈\CQMuF6ru.$yʱY4o *\31R3ZWǧL)ht,}?=W&u(|1bN?(chIh!7t H;^o=&<j@r$G =aqޙq)w( X6?bd\B|1,žc7Jvd'?%f"$]d $y{j'×kv#hvϝV-$D~Lԣ$sQYʒ; !a=ňI} ;c}~Z{ \WL <+|L3?9ѯkYQxV RjI(䫲q[#Fqp{6%2y ,ge9^4v%ٕUr]\Ğꏵ8yuB)E lV؂~:*yh\Ld6+7n ]cO_hg|ʡwlDV"9!C=tdN9WOm7" 4+gq -[w&X[Cvr5 ny bYdPwl> 8,o.1]u8dqC s&ң7$(I 4-;2OeG6GGoj+7mX`2}_F,Q*5ƭxՐsXn8,Ị[@"i Hp ǞVhi"q|uG"ۍd "9-y>kH_r Vpw5\n5Sʟ%3m"I;kӳ8sa8t;,dМ:~'<̗&5HۘqӘ&"ĦW`'TgjMV|_$鐤)0Bj9ݔ3sy,y4zVBHd۠H_]zIV0qќd` \Q/dR϶G7*vĊwtcjѯVErs8EƒAG:S o{IŤ崫yU4EیYF#Qo0FhS#7&dk bFf m \> .@<׬)EʽM´iP>uy?T6'',HD#Ju9lcîjA'oVCِFw]3W]^%#dA9巍as'ީ|rߕPn0.#I]d{dd`K팒ޯκe+*i$[9#v~ Sf^s=\ov$۴! 0P`WGvcJ>h멉o|byRN\ v=4\FMhvuHcSxWy-$nR{oՋ,)PPX6N|1e!m?o\n.>X))sf.`9+q8|We7PvwwI<=>pﲦF՞{xUXdR|5 ՚#X9 t9TIB%rs]ډ(rFj!d o\㰦ɕ%} RF`qyyb2UA=JG t<+㎵M& U#f֪q,[ϦȲ"(ꏯXʕ&70ʪ;WѬc|>*ٕg_[;A;翴)Sy<q4l`$6zrIV9,6ɖfl0:|hgI2(^7lN՝C1@-Xw\w%ɅpKalx8l#ru8MȟK׫[wtʸ ; =UMrT$( s BFrt&9*|Ywϖkz3ڣK˻[wQ3iƢ0P=|qU>ߴkuF\rVm/ hF}jE"{DK 6>"ӳ "QmlżPlZ|kxrA?qs}넣'm}1`\d)aģ@;=cT-IeAq4it&3 o7h#؜8'oZLR!eq<юnѻ@,_R╽ˬM3IncHdY$zW-Z0n%PdЏo}ym-"sکF r`9ڪ">M'j9\}*TϓQӠ [bZFi,)G*+4Td+<䤈Bxrx5EhZ\d>c<SK ݳ{[fN!Õ#Q:>8sPq_SL⫮adˋc1)yu1dmU]Z]rc+;Ҁ*3M-Ć9$N.{GUu@ 7,l3Xۦ9W{ m7 4)mgxLSE\iNF2 &*YiF~$K[\3#II@Ƕ9IG cI³M|ҫ{YI˒GQֱA7XCt]'?n@Fw'~|+ ۼ\#x㶼NQЧLRڑ@ uds~Ze D$}dY巅T}ђcoSDM8I7C/M,Vv$ɸuwڅЇR~*B Ned DjIO6eFqVMߌ0^l-3Ě9~C5|Y\]kDgj'Xڕlۭb`v瑱n\IvodžHbMq> Pbq]4>ظU Nz̛~7lJơVzzȋٷ#?WǹD1ߚECZJ>TwXytku@-Vՙ ؝ޥm [YYNͤmvIe J5dV*{LҀ6zlAUo l}%{y>\上L9 PѻddPr;r|*/ڎdc▍1ByWU\ 3IrrڢmldwFr㎜4mj-4^|Wvb_'l*`FsI0 *.xr-4ScٽbI-[BxqK qX+Ƴ{Y(:+[tBBsrL0j?S^ȩ1Ҭ9ԒrҺwD)+\?}hp' N5j& FFNoZX7+J]q( '8ZҾ٘:jU<7eϧLXItdN#Z5L#۟p1$퓏 @maH]$6@ rʍŬnZ‰NqQm&ܵo0 RhI;67@mRiUC`aK.zʙRbH !Qҥ29g 8DQp62]$dړ#ޗ[ؑ8>懶cM%Fcx~U|zgncZ]>$I7IAR@t\G5#$*sΒu¬#}5M)P4:J,bqOp1 *tӗ'|opVe55S6N*MSo$M`9? -M:۞g8-#Y?wݔS;젱yd(򩧥 K<8ӂx`r|y\eKNI  cs}' ӐFi8*D~<|zɔ=暺 PtA$uؐHgV9Js;ȳFj|wi43`GC}zF:1ΫCs ˑ 3P#Es) pyǽB7B0Ӷjߐ4 :LyiM?0X JtetR 9m!{du NSXn)JTKj5I.䷓ՑHQjEZx.NjڈՆ΢  W9qYʸ?[ YPW̎ƜsG'r#v)W` +1Xu ?HPX"!HuY|8u.˥B8IA*գep$ߩR/P#&;粴$L @(8ݣSrfJ)E5V.s K m%-jѯ,)̒(ʠoV߇|&[F;rv22q/)f6Рힻx ؖAJT zT&k0btoWErr˺"gCw+"N8{ Vdlaԃ|.,36Kxgh*(y\cTA쫭/bNeT 9ԧ5S>;QJw$c6`Fa0O>UsI<$iV8PIF.cA^pEow솒AbPNY$ߍ 乷ehĺX#P'ͤo;iYd3Co#ʉV!NAટ! S"7I'g0;l϶‹¹Vgln=RuF g-U%Udv]Z :Շ~?N]Jg{p(#<07h8ua!Tm';eV-YYc av#‘kYQ 79v {HP6H$2JXsQ%ue A,vXŠO OzRv8,pY:TE|R@2J cCp10ʺR( }0Fs׳Jg+j -fy6Qɢ$|HĦ4Ҙq ;T BHex׫БÎ\)䭭:0XiŸZ\&Yژ(;;EFsԷöC m42 VN1Yp;IJg -ɋl)#*|Vx.aC"VQe LPQdcqҚ_A<賬1IBUN0J)X.ӓ})rkmb"~Ͻ <'m-/ХB7j aɢ@ $|ⴝ=Q=9mKƸՃ"C"1\EЊi|[Tm%wVW &@yf@5[4ǘW8|(BpT^]BDJ*jI)Sm䑓uQm49y4[]( mJ^f9iff$)Ucu3qObJ\E#R; K) u CRJ!1Cgl`kX ]:ʝ8S;@$QUkn5$|kaΗVKogki罒-#C~ t|䮺$cV J JMSʕ_. Rx=զ0s3Dipvlj;vПzt_皏,4|y:Ğt0P ðTTwܑP<6бp;zn+r*m5\m{T)|ΠoFLת֫yt$CrFצq Gʖ t L1.9`ۥ[ oʉZꝵqh#wFХ{96͎QVVn呥,xlGN$.&&ԍȃmT$1#Gv@,e75j:ƣxR#]v1)'%'o譂fSpA@w?U*.H 8{E+ nM*;}4IoE94 Y W$14n?k-; {hHHٵgzt/l*{pj(Ǧ&U;e6b3o8^*-PǫN:yoUa~ĬD 峒C*[3%VR̠#8l|m[H{ 7#A;Q[2ɽStlvkb9*dBv7s7%$hekBUt0x∲ {dRI R!Ny|%ZNs3Ìmu%׬$ Vd@WE&0ƾHƜ?hM T?[bN>X54ݻ}Z W>{c@i|7oի|VfUQBH-GlEEC.ãRK[Ҡ3R!=Z64ҁ|L3O#T*1Iwd|MEk 巣פnGd mD2)͏ q:˖,UlR4 v-'I1PLlp+\LpZ,&2jƊFPca;Sx;mG~C_@ so*whk%N`P:7,u0+mQ1ʐG^萳0]%I9ҡ,Ƿf:`~LԓuDv66slNs`Bw4Y[dCv,4dpͿOYUK#&j5np=r>iS*è;8 Gnb?.Wmol)S+/U(v7&Ɩω2'ʬK!Iz̘D,#o, \1ZM+[V4sRϮ#[og4B*PܑJ氖V( :wW{WmZV4KåX#QCR#5+U܆uQ@tr'WСp Ftԁx iYnvFB @ccsWPW,#޾^u0$Nu(m*bZnl\g{6at5EoE@]!3SWk^k@Ulm{GU7Lm#vj5['l8cէ=,A9rڷ{V!x 9iUn`xU\'޹ۿn#Jξf<0M8e$ ͒I0GLmGl4R3onrJRm-m&K/!XSR'S3XF&6tҠGvښj.ǘ\ 7]3௥>WO5)? !]۩@]߆uK(ʥ)U,o ܚPmZqBᥕ̚5×C\qk F*>Z]'v6u%lPzچ岚v+ڎӕQM;U€q sYUlC;8+f+]aހ[-$Q@T<)"FB©mlѩ6ܚzݫ,7S]D\q,Ιpq,O!i<7Q\ziFVۊ,;J9ɭz[ǹk=9O4¼L=q%Џ m^r& 6޾4 (u2<1$L\۾Wi<*O1eo.mx(h"zu'-8qf;{\-֬^,J/]nx6@Ѥ ;]د oU ! Bw=@ Y46;wOE'_[*%>Z1(*zT5Q U(^'淉`Gtm̟E9lzsh/.ŭGls<9 >|(a129`1K}{2d:˸=7O"'5љ.H?R;y>`@M:sWUrFC(դJo|Yr2[UH\`9;*cj!L4,(c{ǟDuyUTnXo䪬B*vOS.j YuC*pqP4֪yd/@q# zk H$Wikv@&f'%'uAwoUWi ۆԻҠwUlYWrT֧gmq^^sdMQc4-aƭqRUP |5m{ȵLe[(:|Ļ{{+MJ&MAtn*)(E-ZV`bV+EZ+[1'}")YI#I32#O2q֘pG.gEb!#꜃T'88jOM]"/ 7)wfFYdbtE:ĭyu1BčȂy*i$?ia'n2$]aϞq^t1eڌ[EziMⶔruXrHU`1E9D~ wNAF|Mn%SH$λqgg Ү俬@ N6ekBo R.|䐽CUq7ho ^xv8p`810q K>tHˡӭ5O' @10FP*̑ [Lj\ZK"4o 1Un;w<"5iqtn8M$K/g &K2 cJ+nSj  -(y0db@ ?&2{9Cg#jl6)ʷ/2y$Ig ^Z0h`)6i ]esªj S"J'|Odoøվ: 5 YVH#I p]72q-]glv8B3o+>FLJL' 'r?Nw ~f\71ɧzU[ Z{X%LARy ձ辈ꣅ4'ӱ2Rm'emn* -ʀ^`6Q|Fˈo(o7[L6LrbVïh1YvR wͯ59D\,'FIޝki8融d&41rLHmH8Mݥ(bA5,dJW=@q3WKW~UlG}9w99c9Nrysj6mn`}]8I=+UB0{-rrI)HS]..+6s#sw';cT\vzc ,3s|z ˊI\2:ryyyWwB% h*:\xT-1j,ɜ2>> t5jCeO"Y}T}cV;LY@mGF7p6s|U[⢲gfk8ߟq{Ef2T95},κd (ImV 0p=@ݳQ$et5N[xnE`;K帷Yν cJ\4, g =Rjk-U[NAۤHvn 73DtF0FR~;Gl2I>k¬I%ʎذ b I]eb%e86N>ޕWSfJYBbF7Yr7]Uefs$l2A|m\D8*A2*q3\n&HvҾSe;Sc'z mMrFkEY[>#m&Ԓ hdh%WfUvc[.ʥ$"-Iex.hi`,Mfxqk!ua iA,@$ju?w.QOۓhUU Xc(I'yr [ +Z1,UFtmGzzr #J偌>p3|;ѹnkK ʢ '*~qIѴ2pNNاx`@.1=!b? w'xnW%&lҳZq896rpG; jyIl85,[Ĩ>#|Ѥ`yS<|LFܝ*)>$ݹ| Nʨ3< msuq'da3H1Mqwƌv🥖8qO_*Ek[[0x Jm&*RTE%m@ d F&h}RUuoƯT} C} vT$CW!J+x$i#\9>Ryc-Fy*=(S"A#N) |8:o,< gƺ;ĉow5qnF2<+Ø :]'?ƫq##\Dǘ*lX ;;9!YhsI۪%iP+H9o]܌rXFm7{!t99+vS8d5=m!h(շ,_pdӐIRʬ *OW,*鍬KR\Z˻-Kq]Yf^GA]4;wXtb7mξtUCjنj+-Vk~\METs1S.TuE%2GlbaJQno:wf,pq5 LaDѩx^ZvEn2>Qsq{MPcRt9åim\u0;.1cAr *T3*JNJƀ|Bb*<6ϲ`g=kq2gR -YەmVt<Հ?.+=:,_"]+U&[Iߑ@Ƹ{!/2V ;Ү'^5)GPtYHCbKeEo-*{Y'K\vD!$q>@^{w(u~3/| 5?@êjy$s>@ ߠwH#\ 'PN9I˳xRݣsT'G0|_Vi߲r*6?T]D B ˥eUfp۲"pYN2,9>5bt1ʡZ@9MeG&h9{RaIW4ҁv'fRRQ[)8ԔV[*o|qFs]8-ԟjvخjga.&Qx$09گ8ٹ$jpQ3b4ՙnI-[g'}'Ռn)# 37r+; dqg.|FN/R ; :1ڃ>Rx`<7~p vtp k\4u* vJ= E+uk~hں vp.80S/U#^-) $֥/ ̠yg9ɪ%౻X䘁YˍN5j[YFpt{ Oe,uWxG8f6Λ} @{«^*, `KyvK!!pQ8牉 f% KUSae'(Q;>+1ynnU];\S;TjvV*B>5|F,kn21 )bC%9xRT*YpWkX9v+2v ^/ĒHD*)GSNrJݮB3*p@ަ*C=N"un. DU61% w#T~|ӅFHbJJ 'f$cy5"Xy4|yOƶT8Y<}%nx6m wy|U?pq3weUt?GOaR.|6z2RYKhͧȸj6ZD*r|8^19 mב䷽`G_g/T׃3h.0J3[3Sr]Sװ[7kz"d0z+L贱t݆>keaxwPֳ+|2dRjN#qpIǖ+  u6d@]QN,sP0q>ugLF.V$ eIתaBB!F )m%YqF}SKHQ2Sv}Qg]wVfvr%^2I%P*Fxĝyxhr7Ğ@Po/Kr2Ö没&qy/XRki\[EUXlq#ۖ,J49xux2H[ (3з |I.ۉI=GCYecRO=4dI*5-֜>!0F|0å-Nfeb0Kٹ[>ʽD*fuk*mvUKumӥD 5LficTi`m-.A?u\Ir`.N!g.LRve8]A9[Jgm4 @݄`21ʄ+X@`1IaRSk~yeעKOԯ nr P4@xS bF:[K`n FN)M0Z[Eogĸ^H:Al2&Rn[ $=uqJ:Ėݧiq;I49ѓVKest$Yg9|t rY\vݍ_U;|"S۾qpM 29L" (Wkޱ&rvFRv;(• 0ysє+@;3o\ Z^!2?:4uɂΝK!A>|"I!RXxmQK7] =\]2jU衐$+]YduH`9AR=ErQ,`N٬ҫWyp2OHX0|2&+ȺE7kY-"K[>9ڔqq![3jRkGT Ϥ3֓HʓN !yiA:ڽf@#dV\h5)F3tuRuʋs3w01+!U!,]Y\OJyub)EoR/ Gd`vw#HJ=GqٽZMf[j3٩VwMw&<ˇIl`~@mWAhn4}Ig*Fؠ!4W4M­AtZq7 mMe,7{5ݝhgNbMwݛNm%b(эe:Ādeǝ`R۔\)lN=-pDp6~TmV(IZʸ0 [Cq ZWυ]^eo&R&3(ّά,Ҩ 6+Cn6mN5: /*3F9g`zB\Y{cMĀ̯A<کkp7E/qu(q5B#S0q~]Di(̝07@lxDAoƌ earGLJn0N.-IJߦ6nw` LѰu' aMm'LAfiZۇb.9m%ټ*]> qUGGē/8]kfAblfܢ[KxfX㰉xpτu>ya+D Ny mi/dd:KFCqS;r8Z10pΕھ2mkN[b$_-@p@i[\sBMopm5bqs]s=\,Qv[VFܮu':T8c4]($ %qW(L[1Y>SPZ kVʃF0PFW,{W!3o=&y]BFNX@1RPnxihQDTbS[H XEr:3k@hVW+M8(csN6v'<_r锍ogm1Œ7('γ|_p:|c?'o`gnѴ`@ +ƯjMH-9hebyyV2 ʂv:003QXظa(vɾ򾝋Ԩ;@M5<;ܵXC,E㞵W:tГ G s]=qknvL+_.cnG a%[rNRwS|Mӱ0 mI7J>g.eD # Lzq1,|^> IͧRqGɽCqpsqS"_r`>/u.NS>ei7;lOÚlrhԒd!Ԁ|0)Ϣ{ed@IrbHu nDŽ6ΒigGG5KPE+)[rƭ(zP<"82*Itm>ٕslVZ6UyĆBpԳ x1V z|䴖؆ˀt6}ޭXz=Ӱ8? hAe\gXЧ"oP1 9E:_Tc<ȬYO>PYȭK XMrO=YiH c9|+bMĦ;_W+H/Zh}\Мs㹄 =J,|RfwTm& wZKsg,13*ٜU^kld<'X,`vnԀ *uJDˡ˯򬴖+bI!Xgsq=3j;բc<܂yVCca`KolxqOeg*ҝV`ߊ J+C tWEpWE rX2诫_P*WB\Z v]}_V rC}_WdW}@knk@Tdx#{u~piITr=Kb' XUO 0EĦ-| cw=5/醽rQtۣniC zw@.4 l`l7G 7\VK K7J^ /6 `#rI#'rW˃-z ׭8E~ <˻߼p9Z.ќZ;M$}Y!Z. j<'5~H+P2[bOV”7F#M#HNFzk?J=G?1OOɎ.o(yt,L\I`?H%H]`n)=<3$#ȴ+=uZ^ҕڵr*.9kGHSF/T{+Yn*[qˈ!|- `y>x*^O[)Zf/,{ꍪ!P^1S OJKE-1L<(p|zKq7¨ k7ɫsb|=M>stream Adobed     '$''''$25552;;;;;;;;;;   ####''',,,   ####''',,,   ####''',,,Z""  L3!1A"Qa2Bq#b$3RS %&'()*456789:CDEFGHIJTUVWXYZcdefghijrstuvwxyzn!1AQa"2qB#bR $%&'()*3456789:CDEFGHIJSTUVWXYZcdefghijrstuvwxyz?ceZ,66頸Ƈƣ"UHbY$<=,m1$/;yߑ׳]I"@%L1&Vo%k2h|{MU($<7a;M@7v< *qYaӁD,)SP"ιףPO5$ʊ:(`t#Qad(4QF/ K`;禎Fbʠ%t<1f{5e,bCLNu$#;QGw""+ dȈKslRDX2ǚjHOX6'b孯9:f|S;ʊ,]/ߊvgd0{8)"!93M XevKuХ3g@nu#Ō#hh`wi`V6:ywe\  5SU !aU-LtmAvmN~x#Gj3[@6,$T0@@)2"+Rmm7U:3bBƢ-j4Z&"5 y$Bؚi9,,"⫯3`ۭkΕnGFT،u۳$JX,ݺR)盤y2S+рFfkL1Fc*]K-DFu""/k)Q|RtEL$'o䉳 41hY :dTEqTp'vIsI`v!DOI 7k1Q*jUւىafKos7 l1PZg0xt2p[8WDDM,!e:kMjD*.,FSy!Fk1#V #B}{,V3%-Y,r @:[oHƛlܫw&s5 i"+f0Ȇ5@b'}qEd1WMTG(a\3"9{FC=TC &9 h4{FNҘK x#y1((b5Rlwx4hƒ{#cċ*RS{$ٲJ7&ݺlcI=d6KHACxH2p ;2"3NHQC Tמ0"ok.t#1-I  W%RcRY*%=4RPfְ6èۦ5*Qlw|q{^m}YzH\^zuD"%g53k ~GL-P2xij?G 0$2bb6*E,Fz7$"Y⬔zjwP˟UKQRj*DE+߬w7lνPlB:&װbQ9s" ۰]/1d~pTj gu ߕ ◢*3ϋ=TXp>SumNN(88 CQ#4ZzJ@ :X8bU*CEWPjO!\[,.ucu72^@)}&u!5x fNa!Yv rM~P+fI"4S`m>%3]0\Uŷ;ѲRȁB$; :""m[0}LΌـtVrYoq\/)Nd'V6s9t0G&j*h!N0.+hA3-(6<_"Qb. ǵ@2͊tV׎V9""X ;9h Xahύ*V ok܏N؇km=9(3rZnVDDqjG%HEJ lN+ZRBM U_$t2tU #;y%5"T10+fo$[S|tuu "3kau`DDҢi"('QlT:I)-Q; akU*Ad$O%#O R<*)5!k@##c 1Pppوkg",đ=efP nmn_Ίse\k٨֔#NS&覂5-AuU;릸k4oC&خ$ ϷlPDDJdaj^F&Cr zTLRbk*"ICJ]MI,T ؛ Z#b! ocϻ'}h,š1#J`x^pDD@k|Jyݖ.̵ͯݦ}.'q0U&σt%JUŘqsi 6-Tl\6/1XY %̲,k2!eut뭱wUDCqJ2!21l-M9*.^lMDŽq1 f+ĊI@lwk|5=zFl3povF[2I!b'~E R"M(ƵX[Tpj&k`Nm't˛*bHӋlfy(/9k\W 0S:fꝬyz1M/ Jۢ˭-'{Fޖ il"֎C*V!vUekw 㭛4P\ь-Ǹ:f:4rYğpꈗ<*E]2O$ԕ D:#lA6Ÿ]m4qUJ񇶠ģVvaDDH^zcaQhR@ '[D7oռjF`a18ϔ =(UV,FrGhnxA,P) }@C _j$MN Al<^=4XDE_ukb4~,j ,>uiXT3ə"ls#Oq+Hl0whV gh@0ŤE`&r+ e^$t^e~f&{bUB,D2܂tښR" (4Ryk+'KQLɌ N") =\hH$D2qb catO+<&"ꊄ1%75䥒:,#`UjQP 2 =v&DV"H]KDEx#y"=YػԲbRWT`A]C6؂RZ&:fDGkfwUVRU7.cZ@}p-n 1*,qCȈBE<NImd:Ӷa$E'IO 7 pVaX1qac~x,>1ESTZn9l]y1q0-'ܕX"%*JWysb34kᨇ,+̍ZX\;RH)Cnl4^)M$AgZV-Ü-}.J\-d׵5Q f G<.j8,ƳԳDRmw1luC;ƅ6<}*b :9B%ճv\M؊ha\5Ɨkvh1KDpIT3K#"$}^L'MC%ZvVN" e$r.{# Dd,ӡBnOT\ڍR'Y]xb'P۾8RG␨joیJH䥏,K*wcYzXղVkz-:M؊u`i;aS-(İ9Y6QֽrNlU DSÖ1陔]AfIkpn$\[|b =uًDDMIF!`A@=_)EZ*Gŗbf-vb@T*EZ}4qU {`9YaMmb@ɨB"".BwemB4G$+Dhem#nVUѨ9i/}6:D`Ri 2Cx鋽H\KpĈnwK#؃_$tȝ$w Mt'on)ݖ P,5$nuo'9VFѱvfd[zMm ӉMNR&M]FDDDOHeQ-Cew:\*Ha>hP;%-6 <rQ5хkX;vaw휝g[؁=-ܬwjH&@DYpA30r|CɒӫF5oAºLd u%RXYTcqEӷn~d t[]yGF%1i'RE9 [ۛb/#r'D[ًj ͵*f1̒dBEǻ Z1&Gop&Gk@`CC5GmKd䈈խ=G*W:g.Ev 5zs͚϶8"E j7c )u+90*,5C\E}  70l aa_M]򈈺+ũrY+R.O}cSb]V /+MqY4}2Cѻ,uvN%Rtf6b [0 `0bPE"Z&A95"#))bzK[Xw8a)552u-#%l͑z{v`e$Kѣ),o{1Gw 7M 1Rnd0N*80w+ehqq#PM1$T` _}AjY$%ݳ6]Ajֲfk;'O iHXY,#)x+ȲB%` ΍f=oD)(a1X ͖Nz®3X<!Y@RmryJ#`Mb5hv cKH7p 89~Mc%,&b*\$Xf5:YTXt6qֵ _ت2f E·R@GyK_(C)=l,2h8„62LADDWxeR]EM9[TѱzT!ՍЛhM ȵbD0Ys9v6U#*͎"5VFy.Uabb@3)v&ֶ6\]SGT@/cm7ZYE!k-t8.EX ܱ"Β]ZlcV kՎ8")*5XJWRyeQN;U4h^YtM;8M|z%k83$mAR#[2um:b5k/6hmփ)\1s/kMZJ""Zf6)m7Xt4Y70AD@i()T #]qI6яbx!2p(i! N98Շ#ݍ18O=cC&/\P[CiO^4 Ә,EuoW$2g.AqIi+f}1T 3G2i&ӕy"/:x&u\{AWxKjH11ԕEG_{ >ahw6Zpሽ».]/Kp4;>784$Ѡ81䕰1bB Zu3HcԨE3,tt20G5li4 u\ܸ|GY\u fFѽ,]ɜ ae4mVF5XYI> U Rp ċ[sT\UZ9# rb#ǸkpǖHY4 it*K+"'i"1o{.iґae!LWQR="[K_x{TƲKQ HqJctm\+%Lyb gv.k{D9 |i MA%aJ<^JZť-6 fd S:ek6=`cQ]C22}xsV8B!9Yf$umN\o 38jC~8V>#E(k1MWêҥ#hgF,ߕήR4 DZ _ ' Z!FHl۳}*4ɨ+,qDD@-4bk(U%)|&UX 0qql~*|*:>͹QUG":AMEɹܱ2m4I2JaVB45Rt,lFk^č>i-/Vth#[R7"Ɔe7TXjApA4't *]ɽ.njڴ x4tH##",22L D Cpp,)鐺9t0춸W3.csb) 2Ys`X"MRl t+[m=`-2oLE;""%(,Fݖ2dn`ʨIlLh}.N&.%6~aq!`e#Zb&1""P [1r 9f+%c{\ztX멃$ds0- U2 ؒVi6#u/c慏m.g@n{tԝlNmpsK2 x,"DDE D2Y:3s5K2t*}%aOebCJQR4^N-쑰mմH!ZpOe!st{x:pEN Z3"سi3`Y1԰1͙ࡌ­QXwS{pVd0Z:ԔA,G3Iha| ]V+3l-F3OU"%}SI4 #Z 12 mA A#H|"Ҋ$2*Z軨FVSF^6)=imIcb/ۀֽJ.c`Vٍ=qf/ڸ4̑tdt5^b!s.ct7KO+qṕ7n3rrkks/q 襧0&.VױqHm f阨mCE LXDEK?u[=x6N3G WFm{_$ C0J܋` Qx*x#s[,҇e86-CDEOU*mh_LQRǢdSǞ{INW2YMfܖpMa`;6ALl]0R̕/+%z8ETQ퍯 j7B_C#Ԗ"6љ"!xRZe )򂃘RF'^ [ =K↦VP4& vJ9D 1_m}H"L+F-l\Ӈ )djBe^鉙re;v=gR%UcbF8P-yv7^sIĈ~ixTFvs z{Z"ԍ6R`C(:\9iQ(7E @@>¯P oowVLE~-` DVY"C HvM]#˭B&`T4X6L I]XpX}9bS) (iarVqm] KP,( c]h{kjD6D eb"Xe X@aNzjgvF*B˧%V͔עPl4L}=E4 L2G\ 2w9 L`XKsDDVƢ+ZHŶME)9tac⾲eg!׵-x<]C$r[_cܶ# 6_j 5KadMHDDP&OT,owZzq\:V;ĪcI7kR4fm"Pۍo$ZKa.z mDDDȥWXMkXg.xe:'ѧ;:xS)|AF T>!:͠k;'31M ,%EH RU:Xc[EP*PnH~<4>x4i|sK+ W@kڸ%H^McFQc7fa 7%8Ӭ\+em-`o0Kmk`Z ʖ#(ik _V/,tM`9)Mm̜,(Y<UA_/vp["Z݃x!BDtkֹpXfBWS۰cgE mk&1ڶ""(eѳ(fā-%*U&7V E6kdELeUx2rR{v sfHxrܓiiS0$IKs1@Ahkɜjp2 0=6JrzCnE{+ \mp:Ӏk*e5iR2n[ YXfl ͆*hSQB2`A:h6dZw8'Vm̑eadH̦E3D9T!lv x7a9g:kcCE цb}8FkZ45hK@ ""EMQui(ǘkkX熐F ú*)N%UP$:9{-y9m?N7kK% g"ͅ5Vܢ"&KWEw*4b}t6-r6y!ZQU2 ۋbA&C8b6OjuX1$ NDEu:IE`@hO>v> F|ykzqBJ97$yXTepMƖ7@1s[{^@o*牓H3URE%\4~=3t:S:gm>yf>r ؍~2Z f`G!Qt-D : z^tvc\Gpewy-֊ o`>_ӫ I2蓑K ,^n3CDDTƱ1NBX*$ k$ow)HFGO}owD#13`5i$:܂%Gu=9!Hl.u ke $~KͰz"V/  Cٮ  JEpPH TxաB#S`ueѵ-nLNG-Bݎ-)z 5Xbv ~#%,ԒS(-W7uI^*#Fh+gk_sZPI:E۳MF@]iy&IDY fẃ\*eͭe/ rC>:BF A|I*)b㥥ޡU,uu^%$-o:V؋rc495\ Fs],86ORݧR"#HU bkqaUE/hČz ƻx#9NSq/*ye3k{-Aq77LTY$ iԈO ,n[mn$9YnrI'=TS3-ݯ^<.*le s'Ǚ`!iVQb$*T1 aV:]DG }xz@l2^gv26:Y1ƵaD@䈈Id&X@:v5!+KrV7k9_2tH dR94FVLn;v^ĚkD7\O,"(C+MEY4Y Ѓo`!AN {$a2Z)NbVr6=ޞ`D]ώxl huJ""|A+4,C_]].24CR)>_JpY NWٌI-::F\<_Bpw\3ڱ,tݦٌU _V xH%0]aɜ"Z8l z""pBYcBTbJHc}|2G(6`ȟ'`v%lhoV7q i)r0M0MH&Xl^V aϳx%c)Rko{\ێ)$͡x4 wVR.z_\$@#Zs xBѢ<%22^ #5]Þ抒C0pT v-QXyس 0&{xF.q 5;驐&5EyTh-3<[J""Ħ`:8` kp ) 8r5=VrLp{n1iCIqe;Rv\Ƀ(G1=!$yoWW1@mbСmО~}-c*x} )!C JfQ|/ovM=bTIа!NCIO$Pf{G+2[> _҉LD '[[LF_Ulkk{Xȴd|5Zycp&u[ҸQjxQbXF %6c78:xXAWAYm,9Ro+l-)⒩c%DEbw }9ckK i.d`)ߠDDDƓTsbN`yVd"4t'S S!U\(\߳|/sIfh"bzMXѥiDڋC&(M1ڀ dumDDZ/JiɊT0ӿL uc5DPEL6nGXͤ]]FaHûSԡpԘE "wKW\E+#Y&EpԢY^I1DD@F*k*X,#_7C\߆q%Y&1 [* lu8H5NG+gm xIhлgsqa,}Z ] PFua&q³IÕ11?s %pI`nGT eP}$%҇vG0n#"oj@ӕƶ-f s%uɰ $"" ׷pY)Ĭ:jQH)xDDuff2 bSp QJA=|]1'p`Pv#Hxu8y XҶa_j)#lFT`A{o='KBZ{tj[ӉEG'H*L6lofٛ."#RnLDa5ELH)(%S5 *e6t}pZZXsq;Vev 2u…r~pW0%ꛭǶ1]}f# BQVř-q[Q(8h䃝 lf *)#Yǘ $n2ɕ:ESP@!$UgiL6R#˲kZl5 ,6ֵE!jqZn!3 6SazH+#ArLx5L.WL!N}]+L9]0TAif^ ']5s XY AJU\#yR=}$/^)KrRF)1] !y{\\.&Yjr*Z̤mlq4AYȭ:0qLAxXuqٌeUxû)gm̿,q!JZw\d]y 6QOS@ !݌h^/&#f̳2,mܖhqQOg(kӽL\FG%Ĵ@{Ǟc:F;BVvowKe=meBLy3H1@o hj;G&̑9zTN#PI5k4Q>[%H@&ܱ 42gB /{H7/Ucsya/uV-#n=tDETMxiE!= uLE @}mUP4,l{ĄΪ֐dVX rӖ0ưp:dqGYueHx2 RbfU貕R|*:Dd*K/3b0w?j|f`(.y$HG!uk6š-e*u'XƗ^vpnSQEQM*3>Y$mn桒:BJ0F2$aַ`bKXI. ʥ13ڈD2!K>Ӊ0wI:ɘ6anwZXxYDg.U{ []v׿3U143pFzt:2 k-$9Ĉ#$eNhã ԎWEAsrqu5#؉ٗ ^EFaMե(f&5dY: 2ZNmM"B%meT,A~x%i$tRuc*zk" !y9#g@<Ǟ:#I!,r%{Dc( $gs D8s"%J/rܞ-`owġEoمJB [[LVn0SȴsB7:وl'i6;u]wbKjq4D,],ʪ^넵FS:%F3X~[(8|OSZDĐ ތBW>Yk؎ue.8 R2DDLiT҅̕*͝C5'-.5UH#q%2rmUd@#eDvt+-aUBśRomϧd]H.^h\kZ"#/Pdg˦mocm0 ffn*Ownq_ Ro IA2R4f7ZLu wCdQKe N`!,mfјz;Hf]mp'pIv9P l{vÕ7격2Fb XXv9io!MNwLfij4ӕIJ pZu !,=FWSCbkw U*hحl彶o୛f+[p^c,"2)4f({L[$UDa*ɺGc^qowUWӿqjbt&>|:Il[ n(GJ˝l C_tT4̍zލ4RYnUw0]$fηo[_׆\N$.C\\rpv$t!RCA[vF ˆSSŐL\Ϙd^a3+3ȞAo'`olRPz0OY8RFd+nXi&O|-`NAfV]"U\ܬe_b 䠁("RnK"blL/URJ̀=`l{[,*jz&ºQrO~%g+(Ar%QI[L̴礊*ln/$ !c,MT O)@⢗.ڻ:,N 7J8Y򆣐 cp642A$R* Ǽ SIX ]Hu:3He"WX}E"αs 㮫ftSOPja$eQ=8:8c xXĤ|wрw2)\߾urlXQKIi4gpAi0c5"!#3!C FG\QazT!OG7T4uQ亅!Qwc5/|ўefǖH$\n,V82Rm{1jB ""tB:Jہ&HOT\?k #::{c$$|v23V0"+Gp4gmbS f5 _lKr{ HUXe_]F xIa""f*.6il:o["DlfET)/lxx?:O#dLEI0N" ث,,7]tSVc^PQf+^9߿SZꔲ6Hv00qc 02\[j-[aGCG>i ۬Dn7aTZxhQrAk) Z'`F\h0l˅Zd&s\v, Zd1DDD$5XSmuH*7jE}xI^4<0RNkl8 dHB|2}}a}uN"5⹻Neĵ#3+[}o ySu߄%*TH@ٲ_(8zԭ ( V%z-uQM4DEegeTHPyʧY&n0ps+Z~&L; jLx~9 p,gt˞0qӉ `R;3DDW@*EXmd V,&r2GtBiz5QіAF(S6yI̪}b]EN2cK.DDE((S:4!@@,y [s6ĝ,W"{7ts*9}I҄qULЈѧ# ͩmEt!|3HAK,PDĀllvM7Fp2t *-yq]u &OJ""MMua.15R!`y:zU'2lzD YpG,ulmn=h#I'2v}"ג0Km(Ģ"#a M$V~T0_"@3q"Y $\:bJ666E,^8nl7lG""/RU$XZFU^\d׶0xm*<:>6Tp*δ=,]~M1E23dgZkܥ̸ '? [I.BBbXlo䡂tr۞>~ zu$vr n) G~:k'C.٢\vS-HL[\ksZPQ tD.ݜhƇYYkPO<9(9́TLŏ[Ka 'n[UeTͷ.Y2cDm&#?K EMf1fĬ"E*ǘ%!y-scSI:@\̹&R I,ɏq88 =:B$sp{<4<ѻ\Z00b~B/cS1 #*f=aҵ"Iiޒhs-bac=wjVfc9=4-j,:ɐ/)n! bkž-;,$x/^p&zpI""Bd]ƾ9s"Kqd3FrHE2HokL-@dEat-l_/-&Ѓ!m~ . ,rhG~&iy\\Hzɧ̌!zi{,=&3 ilTFgi4!5:H/:m߉Fԕ[[RZA5& o{ֲZ w& fv#[ok۷ 'іkOYm=Q5A.}- ݀ۼ㭫Yh׶Awxfh@2""qQ-ERbV`NkkVqWQe` hlV`[GaXٌ9Q[Xk p8Ԣ""h tꀶ),r6$l\%R,.{m e[@L}%&DDWC4N/T_)spTt YdeP~xe$[Ghv߉h3tf9Mњ""u{(*Xsmnw4ppOWBM}l5#:$=[L.ė%X*~v6Z=̀42cPۈF[g(\REndKZu.Ӈ+KbDwb=U9բ ho\ F`ygJ1T[4̀nA„P֒fFH:Q9)VR5z"L,I|R&koc`4q8jHI˭` 1WND[ RI[bEll`"isAs12ull:f.½*d=d[ECY+I#uWԡjHNm{1>Y)d"XE:v[+h"["5kpQt kvb5# ź;Q>4)Rl:1e:Cfs,kjQt\P/4 {X]_px]k ؑaoifM׃D]쭟f`""%L2]b$`پ[)6aS¨! ֵtD!I6{xL]sqoa6 ڈI׬O^,Jda}Fъ1KH8Z<񩦙X|ua{F:먎Ch# wx | 8mXscTD:w`5;>,DN-3dMMqxXd@8X? _-DP>OX 8CEYR\g=X$V-cf\ =xXa2)},q֖rt:I罔t2]rLdut"" *54/ bzdAK`ʾ1hgPROu!c:ٺѴsރ]/l^$ 5""'֓1dJ3OR3N%[ [luu9._H 2c,zxS%of8IDDQ DNcr YOT! bIm/8NdFF_277.Dzx VNK $ Ȉ5p*96EՋcftXmt|CbsC.t"=xН蘦- tD![E*gqhDɔX_,.u~x'׷kkg-x;ʼn,p`ҵƈ&Fq{.ar7Y$)%CC5Oo$$5"8Ȣ"% CXdSlBHSi v.o vzIQn$f(vrc Xܸ Hh@ѭbdrݾ+[R;_OdB);qv+GcOr6[\} tO,[ Y0}F#okJWVMů~X̂9g$r9DD_T٣.4bXokYҨhn|5dC*0"ǻ`3QUC 2؎e`%8M1tAF4DһujDDGr, o{_MqK%(sifԓEtfR_&_\L^fZ=X;5.Tk h,Sq16F)؞ڜf+,Bn+2R:2OAĝPk'p&ȡM؎$cS)De3kK m~&)P g 関]s ,;v쥤k,} hq#5Ȑ'moZ@y=]Fm55 Q=5W @s*Gȩk6Y͸ϼ[ p(_(EcupBOh#E:*\=w=auX cnߦ#=۳f;yHM\Ȉo< |ps$hoiԒ.Pu(|\C @sh{#Fӌ]wX:Q C W""(K:kkٰ8M3PPxwV̧@v=AA9= ")2]AbnA[Muf9#vFԁq~[f1.4cu?!S{\e=,CB,ô f;+s*Dѵg5#{c\. #ߪlukDDMAGcI,_[` 0ۤk- 0&*i6 mB  *ٓ\q0ѷ- ""SѤ9ف#N]6cf=/bO~X<=i@ֺotK@e'JۆUsIp hun/"0Гf[~>|F U3Gcn/V X#n`eo59txam$sDEhEGv : 7f*Ւ'}l}EU bSDe( u3Mb;ÃK, ""axYyXІЂ4$T, ?"Ka 6b%f&4 f"GifA!0Ӆf_.Wo qC)ld~XC-C2C;)+P5lMG^0 {[0C+KpuuJ""uSMHJ NZiT,ΙSv#J*fQspt"ZxD3EM,ib\)cp/l-DtgiX}Q""(%E3ēlI6{\o0A-qBU@cu:/+SZQXuO;[qGY%=;Mx] 97ƮpxaL#\er2DDDMP8`0= 3e[;1W ׿Qi$ 7RNPԃ٧ëJdcclHlZK`O_5 p&Z""\Qȱ*ݣRu)2ɬmָ7MVSVQл%*K1 7 름;48;%޶>W[Hv\_q+1m=E FmQ̇71b89pcI^k-$RT˟1 r}w r",ocARs3r&BA&fR""Sԁ6U4rN{p0 PBJ]Lg=>cFZZWXg dykkqMm4uшjۓ[Oo׃INoFkDDBp&"tRGlc* R|v͇;[79 ]I>d`s $ki"8ĊC>9 h"1 h*3RKrNRnNG^|6ZjdI iB٬e-W]od79@ $gq $dXi6D v-&YDYؘYw$G{\Mp8-Zx'$w콉/|zK_<1 vBp7-o$DT3{6<>h !5RmaiO/pݬqkCK ^$f+ Oê=Mlw x =+e"*P5ŽZȠ M]fBAj)E|u'BoH#׉MuZ5-x3LFP4]\w@A۪FɔDD+A>@@VWƚN, VYu EIOH؀tl H4p JlHcÍ6f`ltq2)Cp $W^¿_BeK CkO=|Bŧ$籿Ļ-%'WÍm 5aaFԉ G)7œlsn}QKjz0w#+ф.!av$z@n\ gq Iea9#eGU|,yn@4b *]Eʍ9|M*Y=Mш򺵷׳IQb""3)Gŷ,'59%)[MLZe9r:{mO2F}$בr΢qPVPHҧ;#p-TkX̡׬(66.$@6H۶2ֶئG-ͻ4(GHBMN3"SR? YQn$]ȣKjhtq#i ` 20r\"ǨEٻf7C|W K@,}6XG[6""+$T>fb9u'Ƞ]1Z@o/ZUr|^SuMz{-lT05PdT05B""H>ZxrCmO#x#I^bdF,a, ~.3zuDEfnS9QDD]&+pnv|őGkd!RHڒh,/8)n~r$56f-]] sТ"+| "Hݮ5oqف$aS hus܈& j8 [*h42[ >p<ǒ׼rzQ4ӭ5Sc!kr mTpKPF]aI ^XH5 \F*G@ ns2-c^,eŶQD¢/&DPU\X:>&9hfuV&w`I\$fɮ6T&|^e(#67c`umw9 梨!TSGL51u&_(_[;ұyNGb 7^*!<&d#5kTuH Hϡײֶ:,$3"V9p 'd"+)f0 >v_XBQZy"h݀#DX= ۘ7@aE09ϸ>XūDT0v].4kg(xWIc9M#1P3Yd Xۥ\ޑV@ 8̦UѿKLtI8(Zhca+G2VL Lf ""x25 _5lAWOqŭ4K[3!#׷|FSKyBBA u&ON+7vT9YьM`\*jh8&1ΚJ2if u6*@ЃيcWWs؆Z0F~%tX Cj9 /FFhCo[ƃM=27].E4.iڒhjr TkC^ wIzhL2:y.=Ǡh,,348Ƭ0Z[vcFpHuƾ+@Li5К9yUXXq}3\+:͚ nvUu"DCʹ\>iL5P[*Nc3.$L2v6hXv/;|$IɛDE*n *Eqmfo#G22l$ipyc*K8MgFZ|%APAĨz0z2 AfA`㒁hiH!<"-90H)Yy& \4Xnŭ 5`蚰D0i,^w[4 [S-9sϖ&O(ϿTDDcu# F9 ر#[TUL mQȂ7&xX@@$Y<^u[9B42ջI%1,ТL4o(E2H .@Аq}rU@p Q."kf*^v&ߚɊS>5nf2DD"6akЁq;g|u>d@H$zmZkc EpA՚f2^`:\]?Qa" sZGb1t1*E׃ L<,fNSGxa;w_ls觎suZ}E* *_ʍdU%PfԁIsO +-hrsp""--]1@d:CR"t@Cj4b ꃉOC*@Tm0gtF8xK.I ~0|gGqhuE{TEC]L z3PWEKtd\aK-mpE͸r:N-M3"",V&Ģ3W8aе\}5sRQT^2Fme lMюz5-u M6kK{;yhmc⨈2%5GV8&_Q#^&n6Ԍ|NIR:#'YonbXi`5fTLS'eOƌgZKecnDZD%@2Xwn=8#imW!$& rdk#?Hkv:w 30:ѣ=]hf7+OIJ.G1nFH+W6ղ70(وP,,z< 1Y]|w !&dM#gy""(6&Eh1L|"FAe+Fv`ɠf5P P36ws]R Þé{ ""w=ANg/rF/݋ZR81tl[&ZH agMЈH5[dR8h12 !UG9N+*i=r1e/6a7)Ԇ'.E H'#  |,8Qe' 8+UO;=e!H!ԋx*б F^g*[TZY$]ԺwF)= }z 5DDK*,@o$d-WRrB#@m:pΟ&ke~ʡMP,}E:&S4ءn c"z'M2|pԣO04\2LMBg׋L撚 tVIxckd!Ԧ!76:[k*C,s vDSég~=܌ i;"TSʲgMXmqƷdn_oQ/}/hꢣTtDDYY ql򎍔c%xFh,7!$2FfI,`'zbx>Hj»%}jy/$#)SQIنZfDẍH wlwg]@T\wԮxhLSPDDR,,ҡ9VTUjF:|L}KWOP]XooLxE.Rv6cm ͐q1<$x8\2h!cքr"i#wƺ> ek\},V5""XJڶSqqcQMt1 caE1]nloۊ!aGDz"KXێc47InM]F,KE2($vi=GVDܘwi$6WY/y6Bp-`968A)Us[7hm 1L֦h4"jDDKA2(͵>YMYKUӖnPLo{ E!zʰݤZ9gׅwJO:""6^ t~Qkz;ERAxdDEdpG ,݇7VRi3FF{[pp}׷>Hխ hǃJt"Va}0CJOĤDf#H|0ׂB`FҴAD"MՐ5uPm4WnqZ*xhy"nϛǵZrCNvqOh~g#f#yHM{48u!\DDMTtPYԃ#`h#,ll8xζl0ՐBA ue1tuIh7I2 \G؂Z ق*r""Q' Hd%l p"H庐/rH|jV96$y$p#m-68͞htz=7WDE~#HҷL#@-ѩf\8^@Y=lz\<MQX'Jm5G2-l`6[s""!~ ød,FE`ȴMI$8FQltmp&Hq#dĎgńUQ=Y]:]K'F0W|{mۈIV2wf.,7ve̯,C'bDQ" كlq Dc":dvΖ)}PN^CZnBt-M$L".qOṢr5𩢦1-mazskߕēQb'M鈭cl7 x$ š,|v翰5 ug=E XXWpî#b,\]-%`؈,,i^{0v#b)>IzHʹsoߎA0 fLC-MZf{@"".XiMTTҲ`<~]t+9% 0&=Z K2 4յ-ifA"""2b&([Nhv`n#2V4ZSl]B6Uwa,)hi.\ځ㑳eH߈3qZ&Z1oE'qDDMe4 = ٪)4*rWԍS)b:XG\=p!A?5^#uh-l 0Mq"%,x c8Č-8kn;qS×=[zp5d*Ɣy{w|Գăqט5-)zl cc:""[p@R48%f%6 c#YRޞfB9jp<"Oŗ~bp~hb5[6ڴb0cDE|ӏ8jږ;c2u T$ zn$4l PqJ3;b,AM5tYg0J"")΃`;;2ɦ@6]vclnH^DDW *G>X3 BYYƖS~Xap$Nt,ThV ")hd-ʓ1):n=x3,I0&$R{""/)!a<,e ěhFԌ0,Zď3!6v㝭Km-8"4""p/G#fnhN # BF a,-d>10Xk)831Qib\Zp\Miboٍ8CDDTq?&' ¾%HKe66kne7\qNë=+iǡHk >[ st؁en/Nٴ""%u MXWl=cێgHd 2ʦn0-LuifMW3Hx*<#^1Xf8!kMMuqgMHJf̆u:jf!VV?`jREҡow*ѧ{gc! 2tH9l]l0:ea""*䇧9DKs\tNY *4*E0d2 UakmH4"". #eh|Qm19`j-. L7(KlFqY^3FZ7L-,nru#nru#DE1&PEp6',.ѝ@332Lnh eh2>#kd,ymF{KK!f  -C}̸*puMHެF#vxlHΧPG?sͯ @]m-f@ F6?igd,kp.&8Z3GmKA+HDDVV#/Z˭"iza$W̺&\:ѯPjFF9A[i&+DE\neG )JR K{x0UVqAxB.SL:ueFGY:C_ԚDDXw63[GRu^l =#9`D/2M{{/s$}u7 +}&hC_Kt%/QΈ2 pKkm f&˰ a-S-4LL!=xTa`0[)lN3k^l$yB<7b׻eI$DE5*͘unu *Xs7 B9|`ɛ= w"""UR6N-xUNlF!!đ f^@:@9_f/Nq a;v.sF8A""nWScbw_V G+w9Xwv⪀"HفیlV9p1&2E1lVpd'I--1%m.i""kwb1b/HBLLŗ0:h6qKȩ ""٭ g2$, Cx'Or+0C+qa`5S}],7\s*:N̰ r""-lGQC(̬,F0fW<+Yב6t /pƞ`5\!h[n,Lw'aV@Ŷܰ""*IaKG;HR4>wlScd!-MwҼ(%R,㻴aeމhK owqڴ &wOB֢􈮢zn`2xrK!/x依V|SiZrP2AȊ%tXk) ݎZlŁI "u9Rǒ""\-X>鎗 nU4sI\m{{508]2 q""X6aky#Lǰ~M% pgf-R7 h أ9oN vBr(X`A+k|\UӀI:]d`EfՈ ă q 3]C}54)F }[86$^T1VNa$tam"nq \L`u6DDE٠5iVrX-fw@ ~\7mD/@""UCavlhɹCߊ1[@1֌+fmcg,xk8xuics]48""- TB3-=ψ5\rLN7R>[tDzHY;4/HKZǿZGa֖$mc I1$佭ި~""#aT\e=; F2pv(uH,4su{GYMIMDm btu#ӎVI-nDN::$u6𚼅X!kX z]-fI7; d1ƠLݭc rWhծ Gq\@tыHţpVtDEz%HP(vy1cy-A9YN׵6+ Lڛs#oN/$}nZ%|ʞr5ئAuqZ:"8@""#dI.]NNUm*Z Vc3*DE "ߖcES#q':"6JZYm{N}[aXqDDEptH#UTa{'GP G2^vL±TȎDtF<QGECtF>d"-5t3S^$ǥ̌,= ŢqqȎc n2jI]QUF-"c#nѭVhϩio1F[EYIQ2WU{[?O,4S"u-nuam*5c+ ECog"6.ͭ~w\ӽ*DD@>.X_l؎Q3+;wxY403-a|NkJVl^Ϲ舊ɽiê%k|-Bn8Rݧ1ÄH8blkfu=lr'OBf~%[\wpTBh |6V‚yb;""2.H{,&~F hF s7hwv= o~bN(BuAsp4Y<ƽ楛"DRy!c˙ז'-2=xPv'@hFmw\ GU&񨉃ƈF*(=6L-.6׊hTb|?D`6 mL"DS"" endstream endobj 978 0 obj <>stream Adobed     '$''''$25552;;;;;;;;;;   ####''',,,   ####''',,,   ####''',,,Z""  !1"AQa#2qBRbr $%&'()*3456789:CDEFGHIJSTUVWXYZcdefghijstuvwxyz!1AQaq"2BRbr #$%&'()*3456789:CDEFGHIJSTUVWXYZcdefghijstuvwxyz?Ƴk:`:Vud}/pnkBqO.z :G>!dtu;?qpKwt̒"(y7ԂG:XZ9LjoLkCޞz?c؆Da8Ե$ fv UyDgk2'd0DY"3 ="˸оAy{tgeG Ms-Ud |aҾٓM.@lKVGk޺P9'+l

ԁu1E0NVXuZI"I.E`uO4.#66>;"-H_ 8&`F=X lNtDEӍgKfC7@wL k-0D^uqG۬:""/MX!UM@:" ѣ^G@eÖWt*Zz 5:"""ؙo,sgl|NI4·' %nX)҅Ï}RIXbRz԰(>^$[6as0֐L.ezDDLY%XEe; ή $50/FcQfMWo;_ KhsDHYQ t }x}m]L,ɒcTD""+o41G#IhMs8Mö+*6ENER Ăx}Q[Yq% ,raͻH;VP_=g^׵򈈽βk(kνDD^׵{YkNn&ʕ"Rh Yz%1DDFu0{VR˖U04e)HwWUOFkkH#t興׵UW?oa{AʅbHRA˂4m7 bːJMڿ9ס2ĔDDIF>lȓ!*$,AOMe!I'KbKdbyk5?j.nBf7EXW'm>Q^eyLg* sF""Qbi8^EY^^ԛx2H HzDxfmϰ_Ġ@<_ɡ|+Ymگ]A?&mj"H8cD&N;!o4*fsrl޴L؉3,j^zu@٠L%*5vF^69`U-ҼQ̓"n!;AZ?.Z[YQ ct6Q3c ƛxi9T[Q;X{xN=R[X']v&1DrcEfŸP;cT1K^88]ImIΓ'kL0:HѯgrLu DiQ*@$xgWh{uAqPv @yn DP9\\@3+@۫VA8I%bA N݊V.b)hrKbA)UhJ&3ccޠ 4I5+X&hΚ`O2"CW"9^6Y,qD'DXYXL:!shǐ(q`Q R I`A:0!*|S|m5% #oTĪ77@Nk kq@ueadhG\Hc7V li昂Epu^W@F> fdyJ?sf^ч/%8WT/ua{Wi#&_#Ώsn p$8J,$'kG%в@8=N`Ta{FHe[ַ"w3:ihf$ ޘ5FqI==u>^p;1#:,DDYR;T(4u׍rݟ4#R7Х}Gx* UC:XȺ dX{seXR_`zak""Z9w}u[.T%S?;ɯm园d+(Ў2͝ T_f QMwl8aw:,YyqFqᄸ2Lr 7VOa"V$@QXv{K<'w%dRCNA9飏{eli;iۖ`ims{"@"5e~, 珟SLťmn5+]ghAkLrDD]gs&Ѽ..|u&9P#*۪fd?VQm-ŐAS ɁZsEaDDTuB=Eٞ&Y#3^4q&o$h:,m$4A# N""*$/vHݢ:$r$$ڷ h0=:UtU{^׵""k:{^Y=)r{ t_.|&JLPyc+ԍ{p zسq""#XV"מ>=$+P92;[C4YL@C)0>b:$K@(0AybOˋw w jƜabH(s]+..{EcVe8;$5S;_~BG\_h ׷9ōkf ِvTDD P}tkhK0ʏKT#Ɲ2veEY2Qe T ׶^ %5ز-FDDP#I9 UJV`qElFEfI!`2 'Q 7և]s+Mo! s^VYr޶by=UݴEAa:1S&D;v+ƒdqdq'U|SJ2Z9%XqPk⼑91sƩvwkG;'rc#玾K $SWƢA7CY>2U` *HcϖLs I7례KzQzm RnYۃ1Jy+9j79@i)[@;ɵHO/=a<{&M- @oo =Rwm:@-ILaErp{;ͷ@&Ԛ '-KB|o'G(q.>Z}|vջ!7]funvI /;U!ϧ:>0Z]pꓰ#5XYa#4Ke)[ Kgdfkc+B@ X_jD*d 6̨C}JG?&vfɉ<]csWZ^s8XL,%F |/y& SC䉕$Jۋn>=ޗa<!Z8bius'vs$R[1i`l{uZ.V tUea Ǒ ORE3I׍!"{VK:7XRC|t|)JI6y PgR#C1h,A":œ VdqYDE~>iԙ܃xPM:j`3`%B(tL{m0ڱLsU9-QsdWֲB|8jl.u^c3PaAB bѪ+E0ǖ!έnv# ѕўǙzG9h?$ |wa%lnc^Hﴴi`v<2a7h+$!YwQ4szFAkC^HV /q8sDEFtK)kk>Zs2&#xhFEP M^y4,b6\'IC ˎuKiq2B"N[БzѦȵսz$ATtv"*Ak婳`aJxOSZ/iϑ&<`8zr 2duPJȥnصy/HϘ'wkB:;C;+Ă8RwRL҃5Y4DD]@<ڙ,WFe|f;FP7G`Y8nXdDDUCfU`Y(0XA^8)".`pgTn kw˙ueF+'^*RXYZ H#5Yޓ5""3>,ȪJ @x 8R(A hs.NOwjL(  ٥""b#Ery-ޅ7R8c#6)7`zu:x:""cUQT_>Moku{X$IzDDDkIb"nGٝXg&xD%[xnQ^ l8`OP>,ؓ yj@Ջ)m]s$îMTCL-2cU,3Ħ~ĝ+k|ydzIfv+aO "Ĉ,88tȉѹ;&̜瘢㑙]y=Z< Iva*r@|SF""#vPFasjV*T ]lM^'|ycY)8#3. d_ `Jןcb eJ"1Ŗu>B 5-0}%E+戈wrA6QW M&kljєUhV(0qǝ=4*>{ӑ y]hxs0{OjJ$u.v~dӆ `/fAf EDȠspy""ǜ;3`"mKtAsםMSiŐ7GRNdȳ8`,/z>eq-AiO}:-82L\{u"t<0&vU{0„ޥX`ד~{t ;P_,_I!Ȅ  /=:|iI0$0$ eF-\ ǒ j4R4\aea'ј;Vn\iܙ +j\+<^8-D@X<v${@wS` D+BYij]ɻμ"Eu=8$~;=#>1m1to'a }'v5 .+ZbO#١=Ò*$98;q{丛F4 r< (Q?dg#t{p+$5;Jue#a8F] fp^hVݡfYi0'92ih YY:[od>Ȼ&Bdv"l֞Ef*ȵJd$ު{VmEԉאHER\b84`k-08h+lM#J< :X+DwkBdD~ 7ag>Ҹ=&*7p+PY؇^qm"*+=Qg3;De/$)@WR3 ǵµ=Pfc$A$imQ!>"k~ӎ9 r2+D-X߳cznoruڄH;p|i !Dsm,Pr6Ι5~Z&@r62UY%GO5έ^M#:/{<<|7%X^y3䌌7PH`nV`0M#Ux*gwx%5['Sjf8Q$p^qz$DD=,rQmUbR@I19Əq_'VɋݒoAi\SbhȪyFE1%\ ne+r?СIH#,caPh1ug˓;*XogDp.p/hY, y|4Xš/M`R""rO$v"1$$"oEA% wet|>\xw$@s ^|q$ŞQbPoΌesZʶ)3ĈY kvD.*"e^T~]b)״axFfad1BiX=󑇺^K ӡI;,|֍z0;n̳v ADEO p’ IA~m;ɗe,87 ĊZ 5j5n!C7$C^% Q&2ok(kډ C*!m׼c!D_ib5_S>. ↮1ϳgb׻sJYc\.ٴ_v$GNϔxQ9Λ츤숧:@rr“@IL'yd+utO+Վ孑D^DMj5ƨzQ&yR*Q{мݒf3:7aioct興ITi7B8x*!őKcۥFLbl%(ûTwU,iLẂt׫-uA N "-eq,2F/N>-%Q2ͻq̑ȮNhֹp.HGrO;pidmEr3*(Ղ*V#FI \Y[^.rgn S@Io>+ưҞj6 Sϗm6aq3H鈑̓ dG_vgDb$xK9,hz|U}u j`l'ineEe'\i8pw0Qy.ټìHs_4Ԍ4Gb~Qa{4yttn\x*$;E([19l+#.럗JOty%ӑƣsCWW8 1ntOPvԻ*f(uܖ:9٨X7 {~7>[S./lɀӀ' FD0{o( <%}ELh{7& w0'G;\1̆pjmWX_h8;&νHaeɗ%#m[7ˉڰ5"ɵAנ'zS2e3#Lws\jfHuț1Hcd|sC䗲"ðDH0@R^qqV#:8YJnBLGʴ4V%Bצlƛhӽ<Chȯ1S6 G9!hQ='[^,xEf>Yl SAVdXYJe>FT]Dc`w,}I>GLfK2@o~^K4`F6 tЦ"$dfzzjB׵V fyXv%HXEɗ;$ HAħQWs U3;"h{}| Q]"R73w,@:m]zj+{&^<]lP_"#8I7jf`b( k=ǥ(R(s]n1$(nv /?[Rg<)Gq{C޳7HBlb6س_ckfCCCAYb:03DE+Ȫq WӣVH$bcݕ ["@zfUeF*%M/ģ{Qw\txpV FPğQEK1uu΋`ʔ#c̑uEV,_?3jhc]P:WƧdˋdHd2L oC>Ahݯ.+'q:>ev,AX1l$m,(C82clȎ7S@L!ǕդNE9Z)\oe|\ s"ڶLlsy%\b""CuT"}5G"T}6-K df$zt(bCT\k!T]]dP8Ԗ@#iA9oxph.e-MRsEH gɜ ¾k/TC&LLI2"N ^fvf{ٳǞAl|ll9WR@13hu%qi-㷚 Jh^otHL}FtW#lؓa$9W4Jc"c,3 H7׍OegdK9$K-5 {-$cPDE>E6iMX;$EFXxxM"*;M( S$At*|ز0Ah[{ #n==7"/vlmq!h1ƜX*.|+2!?e31c"~]sLE7d<=5 -uސ8H5R+Jވ,(nYd6` p08i2r[X y'h|XnnLG^"@pE$xӯ  @𗒁"먞@`.44˔j&p^8=Ue*Jn^X$8R7Y=y"Dnjfv"k^uM3%Pب qAmn ]dJf@1xѻȈQ(+r:y7ի˛2bd p 7jd/($ !_j>,Ydbe"ŸJlm֛@:(Jrt1̹b\?yTDkmwR2GtZ9*Rqt_r2sΒ)u[$uC{ISnV2d@ udkYkf/KmX7\aѕNa+"R6Tb-%SK zY.~]n<}3 F]u^*s&FyF{n9zd%2!fڜ:K + 2LCq{AJMz}[ˌpaֶoE#c$DD{@:νMzאqWOoC”UUٍ*zlAe""*|O\ߺi}7Bo~o,KRb9-9NJ࣑wβ/s:Q _t_ԼFQ##u2+c\ ,V]#5M`)ӵp$Q(ʼ .,Uh] k~lPI-.k1G6I9*^NDJc!KB jc"c! =4|.Dأt"Zح WpO'sW p8^3/#0 L8>gj8h`DyMÓǙ)Se2 yk>gHeF4}QkFQxV5 kI|}EC6_iZR\Sd?JPvs?rUȏd*% G4M?e0G]H`)I%Vt&TY2O%vxGO]f $,ujqy50z^K_FqF{Tպ9\!DR{O2,˅6NB~OvnJ7! *7˭O3,!s]TQøϥFIC.~) X+(5V9Vzɷ.4Ԧ.YaQ=#옳0eߵˊC^޺1,а\8,:Apo|ne4ѨzT~TĎ#xlaM(n@ !οf h 3+Šd1YK*+u֎o)G /6TqpVT%;Eh_&=G+4k~ݢ#NyaILh:Wkn9^A!I#*WH+E%Sw8`Bw qW%B$`4=|kU=/tZٴ{Ip N9ס5DZfrO #I 8ѳ?\miT̉b1ƛe f0_U㮜ەv<yPh60m7G:DEJG0bHI&EQ0yOXLy5=U P;'QC"N$Bĩ Q=t'1@l`xʋ@@Qc_8l=ĐLI3iLDmUq~"9fDIF 6OZ'2,ʀ&$kQKʩ #M%y7$D$z<`ȓXv4M:Z{N7. z Jgbe5̟}n#b6lsUr;Cri2dBB駏J`1X٫\ NOy,mKւN 0Jd*u""=#Al_':W2E1=(6LJȖ XM!1D+<}ΗHqXGӁ6ٶiE@LId$w-2{i\fl4sG5Yia-p1V"(Q1~km`]묄DDAŏ3LwP۔a穽t YQd nVuZ|a&m 6y8;[(Oo#\& ,HG[Wc G)o{䀌T<\Ñd~]Nȓ+'6BJͺ6ࠂ9uՋ4g$b"5ܽ1(@̢")};fd "{TQ窽 [XBY7QE >.&%SC:`Wl` x.I&=4ꈈ8rCw@7y l"Rb vQ O80#Nj< mgv5ư`9aH,5hb""r"ˊ *w;(,oc|Fx9ل,j_m|;Bxm( uԲM"LJ# PmYudMۮ84'Ic(&ԮPHtãE 3D>iC,c@ $|nӉ\G=||܀3J_OVIxlhU8Vy}Miai`$ bhq*}'10""R|CwG@++w@W$L#L%BB9nGԕ:YYݑ]OMCxwo! CkV{cX:Fv1ac |,hRHb)m莠7zov174zi"_|a) ծSIIٝ[V]hvjnA{mM5DcôDDCȏy0`O&m ^VS"ZY$#h$pzԾђfcvIz٪2N*E޴qVBچ%nHOjˍ"Ӣrp2*BɑXڢ"-rP} M">-(f )ā+w@<4RvvDʫtGZПKggÕ "]$x:gb+AY#&%*.|]U 2O.ӽI$_[!ژK O2Hcy*Q eo.C:LRAޑdʓaS3Dm@@G:1b5}.Ho<'3< T.^h]u/hI#bd#Hz261:ks""&C6TJ$ fS}yP,ޱ =ƌ@JH'mYB{/wvŔ=+p]1e TT7٘Y%+䁻L͆$ O,j[wE[]$i,~=N Ɔ<ަvi \bp~)9)h;JC\& N;J"".NnTdnMd^oҎ; e$/ sz3.ILM6p* ƽF^0[#])~Z!PL)K}J;@"" e0x x7N3!:RZp|\~0+:HEqεp°-c`U㢗" ";t\fJ-ϗsf`IȪIu{Vwb`;ˠfvR@h +ג8!*2 E F71'ցN!Zr^N[cP0 l逈]gHʸՂQ2nU6> *-H6Q W]5RԩYHdi!c/ug <-Ʀ:xdmXE;W>\H`N;-($z|Bs{+aIgv'٪2VDH;'fO]+lhh䏛Rc \\H]:r""g͊5Lx$z= ۊr/hRIAgv_ho@1N `6L\D "Ȭ +} c"nvh~[i̱拝$΍bj}XpE: ˫LsLtL-Gl0DDM^9RPAJ3K "['[w=59=D.R|m-9U3p3Y,ҖtQAɭDoYkLu1*,*%-vND{gYn$hyELہ;كGѩ=cI7H|N1EGb)eWTЃs[j:99{)=z%֐[2oL@ADD^%0K{F,atIU5kwצŮ9""9Y/xmCW4}/H{Ǜ+Am HUG:u6< U@7|8ՐYt5t{|㤔DE'%cE"pAi܌2l 1 C⯂4;h@g:/cL2𑬋N U0:kt9HV4ƽ""s;Q۵$Ù4,4h5 'DcwAC`\beH]+9.-tAuh+\)Q@6a߼Sd57[*舋:k""/kӍ{^Qz =NXH5(|Du)(( ^d?.i1""X˚3F%8;Gjivy~"X ZȱY/d<4-!,BGO/=I*߿ SYDCh*E^4Jx!G|tA֢7pya(eh'v#WgI]|:Y<[& 4 $DD|y7 ṈT(qZ.RC 3KXMtsA1䍧UϰzjlRM#o(`հ>qՖ5`1[Q1xM:= ""&rc.D4*p5{ܐ~1R|&k1ĝGut+5ΘM̥H!]}'^\\kzIu""(;dhNJ!9U4.Sŝp<`W(#SA$8lSsF}u<ַ΅ 1IXPȋ5\r5svՀr0 dtΑ8՘%hhYbvXHTǏ5]qe^C_{Ҁ.0 o]'3Ilp*(l9ׇ. 䑎9S̬V|OA 2Db@:b^5$Tc`9$hZ'8nbj㩾Fx4`@.ֺTrIS!/C_i6,Ѷ3R(p4ʽ%m/ucDD@=,I cpCPt1c8hd]Ē%MX>oz|*2շϖذeL0 xJnբ&`ѓIX8zpHX_+oMj|Y\}/66N(WxW=nև#[de,-B~2|" idM= )͒ ~ĦSGn9'g;3;]u 64Ĭ4ipL{e͌HUh V(yԶvGXH#svEP8yXrHnrd*ZUP12`\ E퇖TtgDj gxِ0DEvN288V={XP't=R6U? u}gw.y=k5M2y)x5|wp&Yp+N8!as]XѴO{x<$t'MiRH$YM&Xi]9y`f%1e"(mo7M,sFF'M,pvPIkۮ$__Ux!LZy˥*x4f&GF 8|t.HprLa76K Cx=]k CIj7h\xFv`|ϬB\hM6 _}dJb"AI }Q' Ls󷍣EtPFLW Eɻy TOH{3F>~I6|wh{b®:G<4M1}'2bAQ >M1,LaMȈ=q,ˆ#xlt<|\7'm NE(>}tڋnя-$`X/ $_80ه\ֆH.xYp1X""ꑑe65M ^~"QՔrGM`<2>|$B ~|X;%q=UỶ5##{X,cCy "" ecYB""/k""ECS{O/29P2;Ψ"ĆG49:kJ*Ȼ ZnlE5xQ]l^ZDDG~dPA_PN̈!\}cIF6vلG"+lEpZ+KO* x\|\uuֿ0A  h2բ""3+,~U@wi6o$Y&LwTk|sˬ``EG2,F+m, W^U*4xקaR 8W$E0DDXEL\ -nC _[,~,*%]BUtױ#&CzcpT] /CccIHbGO@Kt̶w/ ]4DDL|.(*譅,1* R26$JcKI5]:ӘY%|W|O%^CEϮDE:cXP S\|:iguec$Rlm۾Ek"lF =[899֬M&Cs|j[vH~muXvQf@w`e02b F)r9*q8)|i<)3fh\6k#$J""!9Sm0,M!Y268g]-K5켶|0S+!}CUm۰m~ޫf{e{F״(Lh _^uN;f.UDtC"?^Z`vbAyTinƏ|ĐvsƢKG k)8t1U/Nַ=yU]ݗpT,#Rd d饻gNS/٭bfd,/ HYgChȾ!EE0cA9B Wx7nueQ Bª8!M(A,dψxAiXGe!Tkެj553' f@+RBmOFYNITSp${ʳY~B<RO+k6de~y>^׋P?cs`$y 듀caƐ KW{M[*sr2eG+z*ҁaE7dA9sN)%z2cC+,׵Y|LXzzdi|uoxϷ}1£>.G%p`!-ӧ]n0( ˷پt k'dt;']DU@CH^s`vl%6hǮAN_}ϴe"8E5qɛ6 6PR2@e@& ;H\""+:NцCav< <]s14<Ɨf:i}i{A .5H6.IDDW32" (ޤ/ |tf*<gZٲwY N|.ٰ"ݡ=O0,'Y9]ةwX8&̋7\M pa%Ln)08jd+:θ"1,wGl|egaHRTz?ix{P<> N6\kV7Zm:#4&4*b&5ҝ""6Dd _ |*z0?.3; o8"Yj#\z4:%B̢:GfUKd,(nצ NQ@zŞ<VebӼ NY nSEntbΑG Jhs21ĥ$i,`p:^ijb`uH^fNx#xG,{ΐ ,QF$J">ʻU{/h7̌h 8tyyDj5 ઓd^ūXSJ̐HeNΈHڕU]@TCZjԙ0UȂ!$*ϱdI6\a Д`#cNO^zl;aҘ4JdVBb}uvcOycy;_2"IYn;m0s])), Z0F=4QUtDP9ćԅ ۸u-w0k5eI>IwBUM_Jѻ(ɽBZ@, UMǓSZS4bC\")#v)̹#Ig"tF v1 I{Jl.6c TCn)YA,]v6A-p3Joܣ7b贑2[L]TDE2>)E8o|,6 ݥ+cK֨44zWݦK*nҽ~w0{.ҎhNάX7EƃZ d@zYG1""Q1")Tl<4O*I:] -+"y["4d*=(t0}2cibX }. ]>b-?su JuDD\'fed,d̒;#ȲuaeQ "C #,N2upI~"|]OhW,P髅 $05X$DDD!όշWkv͑~}A'ʑqh0v썀yt/#G[{;&:In/ZI"A'ʿ}/y$DDn(FjG,vr.4wE@ >EɖXS`E謹E~Nܳ!+צYY:Aqр3Ob=,݌V%${aO-OygH\:xH<u%$r@U |@W^DDEbf屋#dwB_k~?|5x TATuEh=rqٻ@fx26j-)ȡMu$^4)81""'qN [<$|>bڳ*2!' Y"([ V4|~DG ͺ5`"Kg s%ڹI{ xOiA$l0`O>cX{㬹T#, f5j^w@e웥V&,p5:@U# 5]wE97c= r'I\HqᎯ`%.:e,٢Ņr2 ;H1SAMauuӮƋ;*t,"I lby|൭mg$ހMHpܤ<YwŹghDD[w#mJ+qɦ0/t#g{١i8W18dS3pEE:vH;Aqc?MbFp}]&^b1i>0# 0C)H6oiH'IF!k^#Ϋ<ݟϙ>e4 ׯHN{"܉"6d5 1'[@ e(ƍ#jhR GD֫39Fd""k""k:"""R^y,D$Q/7jcegi8*A,W[-5GdaIڑMl.v2ѯ\v%Iܥe pt興U~%m5HToS~$-$m -m>Q~~h/j&>BH6h XMK5'];PAʫ·Xټq4b4Xm\9`DDDq/)i X+PCMHTu,ф'G 6H|xqrkY0JofcTH'"gBMzg$DDE9`1ڵ]Ah22>J!6Qxmh  )e͉mlT"+/6o{1T4@]GgvT"fRG~M/196k7-=5-} pe@)2""?3yd.X%brc})Jש]CcOt cs2T AjƉSҵnݶC$AU vp,b H' Uk#_k-]pz,S'A'vePs$ ֹ.be.FœjcdX0h.a̽9-dDD,/#ISX6,X^'E$J,H*8 Um~p;%_gaN*E =#ZrI$5$jj까"J&"Ds%qD?o`d9_pHk$nٮE 5,>17$Iah!;[enl_}cCvGU{JXEdL_Q|j U'偡鼞{f1% Nt'fdC)>GV}cfskm'%XY2Rs۶# ͖){S~Ȫ($r o0B3"̱3qHMtDADE|n.#̍{ ?u~ܐHbeګ.Gh6@D계s&$}[` G7z )iA.""+x,yRF:F<*E<hv̞vت/F{ss۽{8"\b|] 0 B3r ̓B&޼yoh]7B)9q(HW5;a*=RMm8r)cWUgiqd_|r E1'N[Gf)v$klhɍ{lc},r^?c ~e ff?!h:`fecFd %AY;c b@IB8ڀ {*vX)LqY_d89|ٴl h0ɎGt쎂n*RVlvUQ]iyv{mc,6Ue4ǽ4[>PҐE<9z-pJ(i˥MtbY P_qGٙqaC{*EUfVb6:*~kLyD]Rny+G%y-ڸ1CZt""S;k/{*?Xion46$Kv]u/|˜p̑eeܪ점 xvMAJ򧱳`s\]z bb,U/S/R6u 0Q `Dn n XʳSˏ/҇ϭTسXFvʼ nF.7u£Rc(g833DDCEY s`蒕tRz#[K<~0"a}evAiT* nDD^*Sn7K#ן#S:S<ҽC+?1؏`ԡMYq/,@/5/lC ""%&H.ERj U|0 l,Y筍h=J`H+|/gFfR9ڴt. u0u͎bS[_?g](2 2{:&2 PR|xAuFwy3IG:߷P d99 {=dDExFLƽO7{c7'wcG Zf4 ,Z,߯˪p HPq&9mh}AVI""I;4ϝ] q ~%YkŘF1-MسL{e A\(zj^,s["Ss,#Hh"3AЂ@<!CK9.|݆88FlxYeEtZXZXkde69NDEPҽN3+p@$qqYH,>Hvhas4gɮ/-$Qزڀi;_i'm[uƶ.y<^E'plO DNq &7_byOTle_SִI7vD߰|ed˱I6^魫$UtՀ"%R @{/ҹ掉۽'~9 }/[eg'{@|NSA.].}Mzyc^,̫2#N-򡺟;Kѻ[-LME8A0)(BTnu|kW;UE $F{.+"YQ`{*U I,2V0k.#>3n.6 7Ӯ4mb@Rі{lz+ٌ9$a2K;hݸH5Y,,QkgF72<HZ7죢O4S!GT:9=Ӧ^twd*dUĊ¬ڧı>O` ;kSDkdip'6Ds^5G=X%J?49d xbAƺIdt( -<'&fGrx}M XX Zv6J硪f "A SNQ!fDadvhͨ"$֏8XU$f~ B)?x=3\Ȧ^=[g Z84 02x3DDM:4DA@lO, ueE&); 珛SSȓ~݆{<^tD DA!x>^֛0MH2:|W"".𤄐A@;Az'IDS1f`9yΤFt<ې yPN9$?dF2I=~YHA=6uֵdeDa=U xTDEW='twSz$d ,,X65Ge!PYzT qq$Ԓdk̪d{\eW!'&=HH8#εmgUQ!"@~Uzn|! Zw{pk88y9O6?jvt.,:|eve]fe#)uғ]ܿJ أ`y랙 a<z1y2H$qֹ5<DD6ga쎝G?6‚ex|*85Oϩ W#ha_0ئiXcǓ#_nϥCbu4ph'q8o:DDEhđ12fPI΀{@@ڋh'y$#$B{.>QѣzC52< Z~^55{x32I27 "*GXsn5<3c16CuaI/͖ž7o>V[+6tU6dw>\ilyʚ]v MpXդfe$c|_K]NKzyJ [MǍZ#@Ȣ`:Hݻ%H4v:lieds_Nʭ 'un$#{*cQp iq/vF<]D^nǓF4֝ v ;f1 L?PgdWᏕu.ʁ|@F A>CR̽4]5ΎBGb#|$(/0Oy WÎ5+6CQF"l G^G7ɯ\"m*eo3USntDȁH%{hr'q}ԏ-.;#7H7ϢF'!uߧ]BS@݊`.jNAgR"CDF-B!(LLQ!HqXtG ~(m#i@]U܌R9?ԄԬ/r $"/Mٌv67z+wB^,vxI<[ZCBN_^ h0MG:aSeLcdZe= cz)":,AOP>$)U΀r3@"QAW_:r$e]MH! A ꈋ+T]с⅋_#:Vlu\O{1)???]F=˒Uw/ֽ$xl\( UsmB-/ צȴ-!7y51F2HDZ*~9eK"&bQ~y}F҂)o Z80:d呸vhc&Z) 1-ƕuVz7[FeB[mZ7S}Hu}\&t09TrF1 tnVHQM P]уT"jU*q=+] .Xmk;=y&xӅe;1jp'ʮ"NP*jˉFpw8OBMqϮev5SBZp "":>z׻S}-t pQ ""/t]+P", #S%A޾\рNDx;t/c=DRSG]+9.LF IT5 mXC]xD$ӮI̤q-τ,A uYd1x+xXv,RW&&N=@=:b-G#r.8N(i9 aJE*ꈈ٘p}P_r|:xq,CHH^OL٣tw8"]UYiJ ;kN$+;sdwJwdzs묧jdŋ<2&dAMmhedA#MMu"8 MV7'&&'Z",iHh1R7e'Ԏ j1xP岙RB<#zSc լc=T㈑]DepT8cUDiU-&*⣴ 1é;PZjUQI G,fɍ@ ߉N1 t. Tm5 sOٸ1Lgݙ 7`DEvmeóWk#S;`I\=C[b:>v0NCƖ97Ãp1vMs1$4s3clcHbr2OِC-laV}kM)χڙ@rv3mD[-rMֈ$1\XպM]}uD^o ӾFgUYbAELS'Y#v\lM0Ew܍dlQ}tH*,hJ(/$Tf.Z&]vw^Q")<$A ahhVD^PB'KG*b#Rǖ B^y{-%SaTRB3do{X`h,xqv 7ùUHDDJMźue߸y$ nu2ز#L Y¾㦆1N #vtBk(jxO=3iÍ$?sbEc+R:b Z`وT0B""bTpf$@43;#fڛU^Fၩ7z ofH2m;x]Md Xk8+(kHZ,ц `v'ƋFՈq<^tR-}8\Uʟ#)RhZ:ɮ$rwH/eͦLuA,C|zO=hk\ؓQ *  P*IgG3Cp}Qcq. qIIU+;[U[򈈌/*̏S= x)+Dm:'F'6tToI(ϗYqc &X85ֈA٢"%%Ns=wR*SŚ'؍'xO_mF(ܧRFDEK;) `s9gl3@V"Wt҄,aa llcI倌"yԭk$Z shX;$.q2G9bLav2[#s@:+(6dEdV}Oײ!Ȓ^f\(ؙq ( ~{,UL otn H8v9 Mǟp`"wRꌀ<6v"H 58>f\VUKH:Mz|ف؞ +i",' #y`I7:KVj ͂1Ӷ3$! NHGͥav237EQEs*##Ԁ$u'jJqhhG2 VxZl 7vghCEm֏CGKh.Nl x4)b賂v@ U@։4zИFݾc@\][MGI{37uLt `H,aI<굶/cvC9S~z ]oBvKY$_uxiӬMDNl"),idc ]Ďx*?..jxbQDj~,O*gf*rz.,]&I!uePxZkkMI7qZ䈈\KLΈRkxwzp3kʒ|C~M{LƚoyrM %QO3(XՁl!RJm^M^s4r/x'P6sYh&Ɍnaa3Wb&%~,!PzzX2A"~&MDyrGץj½J-gףe|5INݚ (`@!)Mth} :N5AQB&`7 yNiLՇ= (%6IEѮ,=a46lIt 6"".^׵T ""]Ajnn^XRR1]SjA5cič9i FxOpԶ /xK2Z ,[x&TDD׋v:2Vd@{}uL3sƃA3nyX ZsSGe;Y<&<GcZ ׀@loeWMZl;)q2""0Xh#ycu$8d#G;Eތ# P6g;ǙyxCި/r$㌪Ĭ˼!Ep7ZstӞwt#FS$,# e5V:uƂCFZlQ%y$?`ѤvEaGoEʍ`;t CkEkl")O#++mwNv[4E\݊şLvGakZ>XC("xk44,IFF.01MHu,6eәcL4nx1nfTDDjccelHD`F-I}}4>wC W]My|.,p8v@f^X^ .^UGTJDTkRtDDhs`I`v$_묹n&Q 7G%&YOٽqC:)yqeimW @8=ol 7u;""N֢JT1**7pE6!ONYQ1fGŜ'@$qԁ"e曲1J 4y4DDITvHX}y>.ƅaŠݹN@uv7[$yt#KT*w _q|4fш !^@Q#oJsֈ!ӡvY&Oi@ ZC'2U]iE,NCϰ՝JG8`oD)&DxY l)a'+&Q{h|khvocoU9L_dx4v` ԞTY+q` <ν6峜.8_&ds\DVjJΚd GOV$zu+Q2B<BOәyz̷ctWs_f2č=CDD[vHdjvݼUQ75D [aXQ+SydUU ]:b+۱ k5'y8XsI8.$ gW6g腶αJe$- M}ƘlL 1b,q_M& D"Y\f׊H^as-+AFD \dךԈcˉě•V{1rΫA[”nuף 9,Qt $&69ᔾzנMv6̊AQO K>|ԅTd|a^TX[MǼ+n#XO tj .1'it`i:1]ǎe@W}߮q1C\Q4Gc#Ijcq]#0.qڃ]y d#]舉Y01$pY'UOZջ2WDn7Dro650!Ґ.un3bxk9I-0nE2 Џ@ 1șrʱH(#b ‣wCi\җ!Xt;|LK$D+J$pZjhtѼMk뤙 yzgE'wl]}n1]P6/k36\;]C ػܝݯA)>G٪\)ycX X$eKco]4Z"*Ss&L5>W}vp U=O"8/}mAedhƼ:hcPXXZ@{]m̤DO'iH]=ѶVu>;b&Ag,֮64Z1vjH8r6yX>N;dA(Ywm|SUAÚJ0 ]W-FƕxRW}l668]t"pB*2 ""N.a/{&K[T:v7g35}q婓!$/, VZcgj>#yߞcIh!ea+220QOEzsZYŁ( o"L%Ŕp@o|kvB6_F W[L-:Q D4}(qrn>@$ݟ J9[t.qܧb~-EHa.C`j ̊ly<'H@iBX DG{ByWudo Ơ()D5O׮Ifa{Zv"",UX#o=#;Jr"um"c1cnDg$K Yx$u54C@:zq 1_U,ju|aA 6@2Ui(ftִK*JeRQ,EQPfP MjCv̘x$bG 몹Yѥ!/ pMśet# .ǙX-c$^I AƵ{0“Yh<ݯڽIc"*Ϲhkef#2\\KM ۧ;1p?zd.IJqF^~͊2y6N:Nэ&ͶĎvN^r0K˒Yl"uR~[εA6JX72]>m3- Y2u`q}46dVw1cƥ` I9uQJ" ˑ4|܅p$^jT5XV5V!(Ehq#|xIT|$a!mR6t,NO%-5VyykۃmwRLz=' {LX#yЮ;RO]Vƙ k;n^-+,;_*0+m[knш1X31ׄDE%\y D㝪˥ "h1!} kN9Ӳb(fvSɴ d*ЯM5p|g*?!oP ޤ}q^IDD^ DG>x^LKHI2] 륱q!͔҆ڀBY:.'kv~ IRV ㋾hYٸAA3`tXvsNDEGgvf:&V [` XhݦHRп-N=hC?fJP ~zkK2:7Ie $V#K_&k[jBރfDh1 ;eSMibc5n~LjG/ F3Ɣh%3\m5>\j=,! /slfA3SͲ}8:=5DK"膉V'H;=y#y]xcT |ϮF[[Ӑd^ϵ ٰDxM*ƃL׷8c& 㘀%~~Ȼb,i uwCw]R\iaA8 y^vdivNIu ĤѯSؽص2IMMaϛKKY=?2;BS6kD( ;;aŗ '-:מ03k4Io_fFW؞,0gp)#nBtc u\᥋ * ,66Ke$D0 ;4u22f8%F 7>cɓ.32>*(wY$_ μ' "+CMm.8BRP[;!=gŶ*m#533+7vpRث:ύ0@``dFY嘜 1nQ3'IS9|XHkxځS G ow3AfZYՠ\h2R 1 .`~XmUI#;nXɢ {c# Rq\ݟ6W8AkIJ۠hQoJhFĝ1]ġzWO$ !O˭b~)(iZXu9psWDDG||v+C*Qԙ$w( zF7l@ܺTmz}m!bώIxj~~ZĐ FHii F hq.D-ߎA~C[.fJ0`[tAT扯!ƮPO^z 8D䞨?c^K8NkU ;238!!;}u[Gjoϊ?o;I uPË].Նt>4@7?[Uqqv/&4ADH7 ""ԛb.-}Rr#2ho[晉jo*wڽhiL\VƤɢzɯ<1781Y!o9Q*p[ ~/5eYQT[4A}m@ rwWe8\QVFr&Hx^A"" x8*HwoIǑ}:G#fPǗQ2vjwJ>x>zby.s/5טBF8YۻR-Mici75b|cq3 Jn͓J' b6I7ZkyF^J""NWg2Hi]Mh(wРkzg+uǏ.T"}/З+pظ8{F8`njqnE"n3PcPL""-lD1lJEnw{$md1*/7(f"?|NH 0 @ #3I '{?m92Eιz-"U4L ʗ-]@Lʼnc(0뜫@%T'sF 2USu â0JҜד;""]4ld4hm'ϞM䜜T;(a<FhHV? D`ލdQ˪R~T >! )`*c,m҃YlqA2odSWZIP1lz:""goݣW}H{1-,p~: XКAb^[Vv8K7 ͐8nU+ Z㝥 uOYcٸL]c>}t/ka&"l/[v VIF/u .dGb݅}k]m޴{l ys6ڽVsUԐyqd$|]HKDdv)@r׳[ŋڛrp8WR\8MIDDMʑDqц%},&2ÏJyAcG4 n] iQzGZ^H.%m #yf=^ 2@*M A∈vdšc/y,` zs&' &yIvZ lk>)5#i"$r@⇝ql}sY-X^lFLJ`mDD@{@b&^dm?6Y/ G8A]k0̊ ;۫VmxyIEa!sDJ6>"饖m*x*d#?&Bb1KAΰS;8{q^DDA,` {7>'Vܭ\G˧;"+HbUk ׆iryNDD_+;T8<*a *l(*kՕehփ lcDD] Ae||2Yd )|@^ѪǸe_ N=z;'*Eko?n۶x1zxDD^B2011M;B,X"HӝHÂ>c 1ě꽌ݳvD)0ѧGg(Zm-.ҠYZ҂:}*$xIS/+|#Wgy)pfE x?`=8;#"H z{53JZxF;"ȶ M~]bvkMl2r{s7w""-aΒ̠ݵOlOKܜ%U*6fH$k9@^ߩZf8'iE욡^Z5Ne̱DDleXw[W3sSc@I=_#k^-lZMPo" dPp =5K ]Q{h9nDD]W,6%_nhɊFl(<90O톅 j>ؾaq4eToZ`I8""(ݵ}dd(P\$>#bJP]dQMȲ}y_9/n٫XD3AP n M]"".tef7Vڥ%AU#lᎲc@U>6H֑Un݁"$ ??4tG|CYY0%եf*J"Zj</)iۀ@ozabD1DJ&g;Ǥ^gj| {Ⱥ@I`4b:nT)kMyu(bӱk{]=6ԧD ֐*l:k I$69隐aoY"3R jIqfʺA;>UTFF7}޴P7]X߷y NC~+(C rFc"h5kSy"l9:!/&:~u]unoXNa㍥Jsa~]`ڌיZڒHFvj(Cyέp^1pUb%uc2 *gPmv #T4G>Ci*v)ܼ5 DΒ{ŒPb73BU[`|JcLaY>77F8PJ:}BR:elE)IH)MtDD endstream endobj 984 0 obj <>stream endstream endobj 983 0 obj <>stream endstream endobj 982 0 obj <>stream endstream endobj 981 0 obj <>stream endstream endobj 980 0 obj <>stream endstream endobj 970 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 0 0 0 1 k /GS1 gs /T1_0 1 Tf -0.032 Tw 10 0 0 10 70.8661 724.8299 Tm (\n\036\007\017\026\035\034\027\024 \023\024)Tj /Span<>> BDC ( )Tj EMC (\024\021\027\024\001\036\027\017\033 \022)Tj /Span<>> BDC ( )Tj EMC (\f\017\020\n\024\r\017\007\027\024\005 \022\017\001\022\036, \002\t\035\024\ )Tj 0.458 Tw 0 -1.218 TD (\024\002\027\026\030\031\032\036\027\024 \026\002\030\033\001\017\027\027\ \024 \030\026\f\023\024\035\026\020\026\033\013\036\036\f\016 \024\002\030\ \026)Tj 0 Tw (-)Tj 0.076 Tw T* (\024\r\026\027\017\036 S-\024\002\030\026\027\024\005 \235\024\030\n\t\ , \030\026\n\036\030\024\n 12)Tj /Span<>> BDC ( )Tj EMC (\327)Tj /Span<>> BDC ( )Tj EMC (6)Tj /Span<>> BDC ( )Tj EMC (\327)Tj /Span<>> BDC ( )Tj EMC (4 \f\n, )Tj 0.326 Tw T* (\027\036\023\030\026\r\017\035\034\027\024\005 \235\024\030\n\t, \023\035\ \024\021\027\024-\220\035\026\f\021\017\004\036\f\022\024\036. \215\024\f\ \035\036 )Tj 0.038 Tw T* [(\030\026\f\f\036\004\036\027\017\016 \002\030\033\001\017\027\t )0.5(\002\030\t\032\036\005\022\017 \f\017\020\n\024\r\017\007\027\024\005 \022\ \017\001\022\017 )]TJ 0.078 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC 0.828 0 Td [(\030\026\007\036\035\036\027\017\016 )0.6(\r\024\f\023\026\035\017\021\036\035\034\027\t\b )0.6(\f\023\026\036\022, )0.5(\002\t\035\026 )0.5(\r\t\007\036\035\036\027\026 )]TJ 0.323 Tw -0.828 -1.218 Td (\007\024\002\026\r\024\004\027\026\016 \023\036\021\035\016 \f\017\020\n\ \024\r\017\007\027\024\005 \022\017\001\022\017 \f)Tj /Span<>> BDC ( )Tj EMC (\007\017\r\036\030\021\017)Tj 0 Tw (-)Tj 0.255 Tw T* (\022\031\035\024\n \027\026)Tj /Span<>> BDC ( )Tj EMC (\r\036\030\b\031\001\022\036, \f\024\024\002\013\026\033\013\026\016\f\016\ \f)Tj /Span<>> BDC ( )Tj EMC (\f\017\020\n\024\r\017\007\027\024\005 )Tj 0.151 Tw 23.244 8.525 Td (\022\017\001\022\024\005 \027\026)Tj /Span<>> BDC ( )Tj EMC (\031\030\024\r\027\036 \007\017\f\021\026\035\034\027\024\005 \036\036 \021\ \030\036\021\017. \200\t\023\024\035\027\036\027\026 )Tj 0.009 Tw T* (\035\026\023\026\030\024\f\022\024\023\017\004\036\f\022\026\016 \030\036\ \036\022\006\017\016 \031\007\r\024\036\027\027\024\020\024 \024\021\007\ \036\035\026 \f\017\020)Tj 0 Tw (-)Tj 0.238 Tw T* [(\n\024\r\017\007\027\024\005 )0.6(\022\017\001\022\017, )0.5(\023\030\017)]TJ /Span<>> BDC ( )Tj EMC 9.832 0 Td [(\023\024\n\024\013\017 )0.6(\035\017\027\036\005\027\024\020\024 )0.5(\220\027\007\024\f\022\024)]TJ 0 Tw (-)Tj 0.296 Tw -9.832 -1.218 Td [(\023\017\004\036\f\022\024\020\024 \f\021\036\023\035\036\030\026 End)-15.9(oGIA)17(Ul)56(tr)-32.9(a 60, \027\026\035\024\032\036\027\027\024\020\024 )]TJ 0.224 Tw T* (\031)Tj /Span<>> BDC ( )Tj EMC (\031\f\021\034\016 \031\007\r\024\036\027\027\024\020\024 \f\036\020\n\036\ \027\021\026 \(\217\017\f.)Tj /Span<>> BDC ( )Tj EMC (4\). \221\022\030\036\023\024\004\027\t\005 )Tj 0.441 Tw T* (\001\024\r \023\036\030\017\021\024\027\017\017\030\024\r\026\027 \027\036\ \023\030\036\030\t\r\027\t\n \001\r\024\n \027\017\021\034\033 )Tj 0.148 Tw 0 -1.218 TD (\200\017\022\030\017\035 3/00. \215\024\f\035\036\024\023\036\030\026\006\ \017\024\027\027\t\005 \023\036\030\017\024\007 \023\030\024\021\036\022\ \026\035 )Tj 0.089 Tw 0 -1.218 TD (\002\036 \024\f\035\024\032\027\036\027\017\005. \215\026\006\017\036\027\ \021 \r\t\023\017\f\026\027 \027\026)Tj /Span<>> BDC ( )Tj EMC (7 \f\031\021\022\017 \023\024\f\035\036 )Tj 0 Tw T* (\024\023\036\030\026\006\017\017 \007\024\n\024\005.)Tj 0.549 Tw T* [(\215\030\017 \020\017\f\021\024\035\024\020\017\004\036\f\022\024\n \017\ \f\f\035\036\007\024\r\026\027\017\017 )0.5(\007\017\026\020\027\024 \031\007)]TJ 0 Tw (-)Tj 0.713 Tw T* (\r\024\036\027\017\016 \f\017\020\n\024\r\017\007\027\024\005 \022\017\001\ \022\017 \002\t\035 \023\024\007\021\r\036\030\032\007\036\027. )Tj 0.196 Tw T* (\204\026\022\030\024\f\022\024\023\017\004\036\f\022\024\036 \024\023\017\ \f\026\027\017\036 \(\217\017\f.)Tj /Span<>> BDC ( )Tj EMC (5\): \221\036\020\n\036\027\021 \021\024\035)Tj 0 Tw (-)Tj 0.026 Tw 0 -1.218 TD (\f\021\024\005 \022\017\001\022\017 \007\024)Tj /Span<>> BDC ( )Tj EMC (11 \f\n, \r)Tj /Span<>> BDC ( )Tj EMC (\f\030\036\007\027\036\005 \036\036 \021\030\036\021\017 \024\023\030\036\ \007\036\035\016\036\021)Tj 0 Tw (-)Tj 0.051 Tw 0 -1.218 TD (\f\016 \027\026\030\031\032\027\024\036 \r\t\023\016\004\017\r\026\027\017\ \036 \f\021\036\027\022\017 \007\024)Tj /Span<>> BDC ( )Tj EMC (2,5 \f\n, \021\024\035\013\017\027\026 )Tj 0.036 Tw 0 -1.218 TD (\r)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\n \n\036\f\021\036 \024\021 0,4 \007\024)Tj /Span<>> BDC ( )Tj EMC (1 \f\n, \f\035\017\017\f\021\026\016 \f\024 \f\020\035\026\032\036\027\027\ \024\005 )Tj 0.093 Tw T* (\f\022\035\026\007\004\026\021\024\f\021\034\033. \221\035\017\017\f\021\ \026\016 \027\026)Tj /Span<>> BDC ( )Tj EMC (\024\f\021\026\035\034\027\024\n \023\030\024\021\016\032\036\027\017\017\ )Tj 0.125 Tw T* (\002\036 \024\004\026\020\024\r\t\b \017\n\036\027\036\027\017\005. \204\ \017\022\030\024\f\022\024\023\017\004\036\f\022\024\036 \024\023\017\f\026\ )Tj 0 Tw (-)Tj 0.032 Tw T* (\027\017\036 \(\217\017\f.)Tj /Span<>> BDC ( )Tj EMC (6\2268\): \200)Tj /Span<>> BDC ( )Tj EMC (\023\030\036\023\026\030\026\021\036 \235\030\026\020\n\036\027\021 \023\ \024\035\027\024\f\035\024\005\027\024\005 )Tj 0.107 Tw T* (\f\021\036\027\022\017 \021\024\035\f\021\024\005 \022\017\001\022\017. \ \200)Tj /Span<>> BDC ( )Tj EMC (\024\002\035\026\f\021\017 \253\027\026\030\031\032\027\024\020\024 \r\t\ \023\016)Tj 0 Tw (-)Tj -0.046 Tw T* (\004\017\r\026\027\017\016\273 \f\021\036\027\022\026 \030\036\022\024 \ \031\021\024\035\013\036\027\026 \026)Tj /Span<>> BDC ( )Tj EMC (\f\004\036\021 \020\017\023\036\030\021\030\024\235\017\017 )Tj 0.04 Tw T* (\n\t\001\036\004\027\024\005 \024\002\024\035\024\004\022\017 \f)Tj /Span<>> BDC ( )Tj EMC (\027\026\035\017\004\017\036\n \024\004\026\020\024\r\024\020\024 \f\022\ \035\036\030\024\026, )Tj 0.499 Tw T* (\027\036\030\026\r\027\024\n\036\030\027\t\n \023\024\035\027\024\022\030\ \024\r\017\036\n \f\024\f\031\007\024\r, \024\004\026\020\024\r\024\005 \ )Tj 0.178 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\017\r\026\f\022\031\035\016\030\027\024\005 \035\017\n\235\024\ \006\017\021\026\030\027\024\005 \017\027\235\017\035\034\021\030\026\006\ \017\036\005 )Tj -0.007 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\n\t\001\036\004\027\024\005 \024\002\024\035\024\004\022\036 \017)Tj /Span<>> BDC ( )Tj EMC [(\023\024\007\f\035\017\017\f\021\024\005 )0.5(\024\f\027\024\r\036. \215\024)]TJ /Span<>> BDC ( )Tj EMC (\035\017)Tj 0 Tw (-)Tj 0.254 Tw T* [(\027\017\016\n \030\036\036\022\006\017\017 \016\r\035\036\027\017\016 \ \b\030\024\027\017\004\036\f\022\024\020\024 )0.5(\027\036\026\022\021\017\r\027\024\020\024 )]TJ 0 Tw T* (\022\024\035\017\021\026.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 303.3769 383.8458 Tm [(\037\036)10(\032\223\212\226\034\022\031\034)]TJ 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0 Tc 0.141 Tw 10 0 0 10 303.3071 359.4898 Tm [(\211\007\r\024\036\027\017\036\n \027\026\t\r\026\033\021 )0.5(\007\024\002\026\r\024\004\027\024\036 \026\027\024\n\026\035\034\027\024\ \036 )0.5(\024\002\030\026)]TJ 0 Tw (-)Tj 0.103 Tw T* (\024\r\026\027\017\036, \022\024\021\024\030\024\036 \n\026\022\030\024\ - \017)Tj /Span<>> BDC ( )Tj EMC (\n\017\022\030\024\f\022\024\023\017\004\036\f\022\017 \f\b\024\007\027\024\ )Tj 0.068 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\024\f\027\024\r\027\t\n \024\030\020\026\027\024\n. \211\007\r\024\036\027\ \017\036 \n\024\032\036\021 \024\002\027\026\030\031\032\017\021\034\f\016\ )Tj 0.069 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC 0.775 0 Td [(\035\033\002\024\n )0.5(\024\021\007\036\035\036 )0.5(\032\036\035\031\007\024\004\027\024-\022\017\001\036\004\027\024\020\024\ )0.6(\021\030\026\022\021\026, )0.5(\024\002\t\004)]TJ 0 Tw (-)Tj 0.026 Tw -0.775 -1.218 Td [(\027\024 \024\027\024 )0.5(\030\026\f\023\024\035\026\020\026\036\021\f\016 \r)]TJ /Span<>> BDC ( )Tj EMC 9.96 0 Td [(\002\035\017\024\f\021\017 )0.5(\022)]TJ /Span<>> BDC ( )Tj EMC (\023\017\013\036\r\026\030\017\021\036\035\034\027\024\005 )Tj 0.1 Tw -9.96 -1.218 Td (\021\030\031\002\022\036 \017)Tj /Span<>> BDC ( )Tj EMC (\004\026\f\021\024 \017\n\036\033\021 \f)Tj /Span<>> BDC ( )Tj EMC (\027\036\005 \024\002\013\031\033 \n\t\001\036\004\027\031\033 \f\021\036\ \027)Tj 0 Tw (-)Tj 0.381 Tw T* (\022\031 \017)Tj /Span<>> BDC ( )Tj EMC (\024\002\013\036\036 \022\030\024\r\024\f\027\026\002\032\036\027\017\036\ . \210\002\t\004\027\026\016 \035\024\022\026\035\017\026)Tj 0 Tw (-)Tj -0.013 Tw T* (\006\017\016)Tj /Span<>> BDC ( )Tj EMC (\227 \007\024\030\f\026\035\034\027\036\036 \027\024\030\n\026\035\034\027\ \024\005 \022\017\001\022\017, \023\024)Tj /Span<>> BDC ( )Tj EMC (\024\021\027\024\001\036\027\017\033 )Tj 0.135 Tw T* (\022)Tj /Span<>> BDC ( )Tj EMC (\002\030\t\032\036\005\022\036)Tj /Span<>> BDC ( )Tj EMC 5.391 0 Td [(\227 \002\030\t\032\036\036\004\027\t\005 )0.5(\022\030\026\005 [1\2263]. )0.5(\217\026\035\017\004\026\033\021 )]TJ 0.056 Tw -5.391 -1.218 Td [(\022\017\f\021\024\027\t\036, \007\017\r\036\030\021\017\022\031\035\016\ \030\027\t\036, )0.5(\021\031\002\031\035\016\030\027\t\036 )0.5(\235\024\030\n\t \031\007)]TJ 0 Tw (-)Tj 0.164 Tw T* [(\r\024\036\027\017\016 [4]. \211\007\r\024\036\027\017\036 \024\021\007\036\ \035\026 )0.5(\032\036\035\031\007\024\004\027\024-\022\017\001\036\004\027\024\020\024\ )]TJ 0.136 Tw T* [(\021\030\026\022\021\026 )0.5(\016\r\035\016\036\021\f\016 )0.6(\030\036\007\022\024\005 )0.5(\026\027\024\n\026\035\017\036\005 )0.6(\030\026\r\017\021\017\016, )0.5(\004\026\f\021\024)]TJ 0 Tw (-)Tj 0.128 Tw T* (\021\026 \036\036 \024\002\027\026\030\031\032\036\027\017\016 \027\026)Tj /Span<>> BDC ( )Tj EMC (\026\031\021\024\023\f\017\017 \f\024\f\021\026\r\035\016\036\021 \023\024\ \030\016\007\022\026 )Tj -0.039 Tw T* (1:4500 [4]. \215\030\017)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\n \f\030\036\007\017 \r\f\036\b \007\031\002\035\017\022\026\ \021\031\030 \240\025\230 \007\024\035\016 )Tj 0.15 Tw T* (\031\007\r\024\036\027\017\005 \024\002\024\007\024\004\027\024\005 \022\ \017\001\022\017 \024\023\017\f\t\r\026\036\021\f\016 \027\026)Tj /Span<>> BDC ( )Tj EMC (\031\030\024\r\027\036 )Tj 0 Tw T* (12\22615% [4,6].)Tj 0.016 Tc 0.1 Tw T* [(\210\002\t\004\027\024 \031\007\r\024\036\027\017\036 \024\002\024\007\024\ \004\027\024\005 )0.5(\022\017\001\022\017 )0.5(\027\017\022\026\022 )0.5(\027\036 \023\030\024)]TJ 0 Tc 0 Tw (-)Tj 0.016 Tc 0.172 Tw T* (\016\r\035\016\036\021\f\016 \017)Tj /Span<>> BDC ( )Tj EMC (\024\002\027\026\030\031\032\017\r\026\036\021\f\016 \022\026\022 \f\035\ \031\004\026\005\027\026\016 \027\026\b\024\007)Tj 0 Tc 0 Tw (-)Tj 0.016 Tc 0.074 Tw T* [(\022\026. )0.5(\230\036\n \027\036 \n\036\027\036\036, \r\024\n\024\032\027\024 \030\026\ \r\017\021\017\036 )0.5(\024\f\035\024\032\027\036\027\017\005,)16( )]TJ 0.23 Tw T* (\022\024\021\024\030\t\036 \n\024\020\031\021 \023\024\021\030\036\002\024\ \r\026\021\034 \b\017\030\031\030\020\017\004\036\f\022\024\020\024 \035\ \036\004\036)Tj 0 Tc 0 Tw (-)Tj 0.016 Tc 0.37 Tw T* [(\027\017\016. )0.5(\200)]TJ /Span<>> BDC ( )Tj EMC 3.66 0 Td [(\004\026\f\021\027\024\f\021\017, )0.5(\027\026\030\031\001\036\027\017\036 )0.5(\220\r\026\022\031\026\006\017\017 )0.5(\022\017\001\036\004)]TJ 0 Tc 0 Tw (-)Tj 0.016 Tc 0.33 Tw -3.66 -1.218 Td [(\027\024\020\024 )0.5(\f\024\007\036\030\032\017\n\024\020\024 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 10.351 0 Td [(\023\030\024\f\r\036\021\026 )0.5(\007\024\004\036\030\027\036\005 )0.5(\022\017\001\022\017)16( )]TJ 0.167 Tw -10.351 -1.218 Td (\017)Tj /Span<>> BDC ( )Tj EMC 0.949 0 Td [(\026\f\021\024\005 )0.5(\022\026\035\024\r\t\b )0.5(\n\026\f\f )0.5(\n\024\032\036\021 )0.5(\023\030\017\r\024\007\017\021\034 )0.6(\022)]TJ /Span<>> BDC ( )Tj EMC 18.436 0 Td (\021\030\026\027\f)Tj 0 Tc 0 Tw (-)Tj 0.016 Tc 0.833 Tw -19.385 -1.218 Td (\035\024\022\026\006\017\017 \n\017\022\030\024\002\017\024\021\t \027\026\ )Tj /Span<>> BDC ( )Tj EMC [(\235\024\027\036 \023\024\r\t\001\036\027\027\024\020\024)16( )]TJ ET q /GS0 gs 221.1023475 0 0 252.5512348 70.8661351 360.7866259 cm /Im0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0 Tc 0 Tw 10 0 0 10 291.9685 360.7699 Tm ( )Tj 0.085 Tw 9 0 0 9 70.8661 349.9699 Tm (\022\t\217\210\b\002\220 2.)Tj 0 0 0 1 k /GS1 gs /T1_3 1 Tf ( \215\032\032\025\202\n\t\013\n\033\025\002, \f\032\n\021\024\026\023\022\ \021\026\002 \033\023\n\t\013\n\t\024\022. \255\033\032\031)Tj 0 Tw (-)Tj 0 -1.2 TD (\030\031\023\002\031\024\t\002 \t\023\031\033\n \016\026\013\026\021\006\ \025\027\026\007\211\031\031\t\002 \205\030\027\n\031\021\025\031)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.028 Tw T* [(F)-16(igure )0.5(2)16(.)]TJ 0 0 0 1 k /GS1 gs /T1_3 1 Tf [( )0.5(Ir)-16(r)-37(igoscop)12.1(y)42(, frontal )0.5(plane. )0.5(A )0.5(blindly )0.5(ending )0.5(doubling )]TJ 0 Tw T* [(is deter)-13.9(mined)]TJ ET q 70.866 122.596 221.102 184.469 re W n q /GS0 gs 221.1023676 0 0 184.4700222 70.8661485 122.5959129 cm /Im1 Do Q Q BT 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 10 0 0 10 291.9685 122.5959 Tm ( )Tj -0.034 Tw 9 0 0 9 70.8661 111.7959 Tm (\022\t\217\210\b\002\220 3.)Tj 0 0 0 1 k /GS1 gs /T1_3 1 Tf ( \215\032\032\025\202\n\t\013\n\033\025\002, \t\026\202\025\024\026\023\022\ \021\026\002 \033\023\n\t\013\n\t\024\022. \255\033\032\031\030\031)Tj 0 Tw (-)Tj T* (\023\002\031\024\t\002 \t\023\031\033\n \016\026\013\026\021\006\025\027\ \026\007\211\031\031\t\002 \205\030\027\n\031\021\025\031)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf -0.013 Tw T* [(F)-16(igure )0.5(3.)]TJ 0 0 0 1 k /GS1 gs /T1_3 1 Tf [( )0.5(Ir)-16(r)-37(igoscop)12(y)42(, sagittal plane. A )0.5(blindly )0.5(ending )0.5(doubling )]TJ 0 Tw T* [(is deter)-13.9(mined)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\037\035\030\213\030\003\t\021\037\030\t \213\b\214\035\200)15(\255\t\213\030\027)]TJ 54.711 0 Td [(C)10(A)20(SE REPORT)]TJ -54.711 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 23, \023\0221)69(, 202)69(4)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 23, \023\0221)69(, 202)69(4)]TJ /T1_5 1 Tf 25 0 0 25 20.7776 56.0378 Tm (138)Tj ET endstream endobj 971 0 obj <>stream AdobedC     '$''''$25552;;;;;;;;;;:  w!1A"Qa2q#BRb3r$ %&'()*456789:CDEFGHIJSTUVWXYZcdefghijstuvwxyz?a@ ckA*,DVX'q8*rl5vb4t5\s,-b=P$ }kY>^UhY{+uI ݈{\&!ak^ +*Y4RÛr?rK3_Nо@cy>\vb`9åR I2ʤf6#o]b2*o_U;kㇾϥ5a[i IWEwZlowBN_tTg[EmEtp8&mƸ|>v0SӮGǙ!e$+٭}49o~(3O bRԕod8ݦˑ[\ğִ’6ݙo L4rI1s(ݾq̈D:^g%R"r\wXWk=!b/^>Wf0Oʲb3FGI'0 VmwxH n7HȲBr$;Pvb婞]C$b%ZU("f#z_ta۰Uu7#oD#mFVx܎;"tXS'UUJD܃_a`|^((Eg,Ja٥dɹsp q`8zUCڷ´btU$hdb&mnOkp[vL19›ed=@>)}+xZ(!w J_kp s[@R q >Vr7($\\u{6ՖhFQ޾JS ^ea}4lorIҹA!AѮ[GUo:7pzXΠw>72d&-`: ɱcsт \.򱍁`uխ 0s\;J ]eeEbvH [6H\ebA;My7yIWBt3yWجL=4jlXZ90pekHQt4AP _nq'IX}kDn 9sFtkVYta0u;qp,sm4w%h8^QI9Y(n]1E,Yw:WYᰟC[ S+31z]fR"ƇS F}({X0D0gm[CAb:Zd,8AmPa!HWKe|Df :YEoo]W}wޏã6Y-aa;OBʎn|l3*][/ʲC\&VH߇ 70pZ"[BM ;kٰO!HɌe``u+Ӻu>5)'kԠ;ˌ`#ˠ=`@M24}&Mf,aXlA MuzCF 4X xgo剹;k!]%O d a~EK(2_aXf7i,,CV-"AS(Ȣb3dGbO+fGT^1I[M°bo'UAH9r[#LYd ]O;ou.K_#3t0`)6[ߤIsR|T)6614 LsOmc)Ustx=Us(kk/`CDž2d}/c븣,AV+}\XqckT4o+V'FÛku Hr.{kD2aM1AM8f66pM<÷Z5pNmh-\ EWщP)5i"iB܀o+y4q_Nhm0y^5඙k}) ] {=D6#VøVk26$b;[Ƃ^v ˶^7 JVj!9zHH*@J3q5ꓒyLbaQDq֏"6D9H$3yԇ. 2ztm0weƜ-o}Aik2;؍+[R:Q0T`ڒ-{a)$X`{^HVnUۤZ[yܣ(&#[ZyM<+܋u hq[Z&% 2POU2zr& Ac\aND+ğ |EZjz b;nWLJʠ * "Dq~k {úBbG})V4f߻&Q-հ6aK@o2+5( q 6ZmV|1 n=C_: R;5L&0UA uyӌ..7V~tѹs lčǕ.<@f?{]2n,ׯJuװ'Mc&M %emKlﮂtm޻. _cف's !汌-9ۄK_r ^y܍Yu-[Q؍(V6'̀3[c Eٔ;/oЩfjVM%7KcC9ۉ\iu zƾ+Ĝ56=HxBtt$`羺bYTZN' ؼ"ȝ,ʧMNEc,d*͒nr/vfXg"Bi@W>:_L2:&b$c4d@µ+"dA}|Em )$X$e|Z) %2«Xbs>o`2F#l4z1"AA máAJSAwnYŐ4NBuji7,J23vk!;kJXf, /ƹ?:D\_[[z i9'鼲& 9.F7"8!EiGȨW|F"*4lF>]7 }Mž(̱,wjWPaݝ|\LܵR˘jEn!0E,Gʺˉfg &SKaMf57`=ܭ ukJi]z`Nrz\zV :>6?wG<]˭Z%dg\yXPH]/p}txXWV\2e,Fa{IUY zEJ;ТeiU\ M Yeu(#[ucą\Sf pxRDh 'f o]Q\Q8`Ǧb}Uʻ²I6נ Nh|e뀉4e #w68iC )%aÛչCck`ݤQ6x&A|5H' J4[@ ` :mA\Fpnej\.F2V%3=p@B`G] aU|^*&Id[ԓE&r>II;n5QUIDDtwa,j}কc~ S^bnFָy+:m٣)9(3t~dNLU%K7&#m$q|0eƠHJP9*YCasۇ^&"\ȧ",4"RG,f|;ծP8GQɱi͐q?'<*u9OrIa{߅A7sZjò89=3acp= *ʤJZ9'4\jc%WLT& T`,xuq[kF]5VR5a(R Xq}2v:'b+(n# VʉUʦ3a11[nG|f&,;3@ٷ5'aFgPyB4l=cXG\sXK3B;ػit'v>cfRBޥU`иrXzSlHQc* h;bEsꄁUw_<RAg'mko.Re`G$+;"2b$ a$V2)[5[ 9z +8~{O "d^u3I)oƿm3g(>_ʻI L\ {]Oܫh9cU l8΅*8˔u EC0ZQD,]a:pD.X=B-+討 J6E EA+:Qcqgcb1@P @l7x9uXF2x]ORBQ1&%`.~נ>$(pzFުۚfU[iƃ'G3H޺$aa9ZBugvk#؊Lن^ l1QI* P=SjOFDEDWx#xn͠B|mL976"!c_8 V7Xd=³Gˉ{sHoU6`+j]E7(ݕ~؁UW82#pˠT U؏qY0ʫ6[yVm ~`hzWj `8 eͿF榸5#Fcr17\+9y˦TfֺLLah,~x`K9.᳖+  B8ۏUTbT98U r"O˔:!69O1l4 5  21mop|v*,yV*O9vaWwSK ѐG*5@%#@A΍R8-2Y`Ruc*!I6s#0ۨ9bg6Nm -fQX2 8y`ɅP[R >]!\ͮWpG:b٥[fpAe=g1 8uz ZQ"XE,u^r!. Y @IJ~H݁p,ֈ8vY9=u70<ˏ<6+L;pZ w rE@߅cs7YҴTgb͡7#!u<,82$)T&xR̶8FT5lp5]"0 Y6#[zt,#72":ʺk$Z;Y ѭy KK :m7qKjmC ,nFQa)Y- <tl5$tm*L/EN'!{:Y|E0I1%oxk25U{d,ue;NRlK\Iq-ܖ&qh$/FRN im[AX,;IN\oP֎q{a++g:}710B5Ө} >10m~V`](5T.KB$ Pp F"&6.ew"g`}|h\wJhu͹ ,LFW17]E(\Wqs@_[ܖTo#Z m7;уKpYi!NXJ1fBoՔ+.wyQ`l9đ):E&G':&SFLq^X'#wH^mΠk!Xocl8cUm=Y$Jf']C@Ēuz֨ܖ 4~RD2ƃ\TT\,<ı1>øDÜ,i@noCkSkBItPkʒG6{WqUTW_&b$E*ŷ]uͱ8InoQm4ZLsk\:[d%z;Wb"ȗRטxVğf?({ZʳcDG*2nPKSQaRNKkaG+[ cU,-̉Xc]l ermǣ* :n00v\%m,1oZ Cs0'G[xVLT 8Q@1bE0+ {s#((+QhѸtNN:^OekZa/0n^Urr4Eäx\܉&ջm]qKr#[Zq)2-v m&kN׌K&,qr EYWnI]h%k\UmZZI7ר&\>`uwL[B3 9y PrG,by-='<<,Mm;'bLy,Wj оr+PAu,<&QoĘAS$ ֍iDy6_Şulv,C4ZlA$hM42AnMg#=dWλ͆yU &>o=3qtB.%rlۦҤxnLܝFX}3y0\ ,#PgbWN|2lw`Ǣ hAjܩf|=ћ))b*4%gmntr;|U}vtfU`5РeYL#ANrU 1N@:VE]^V6 l&Etdg.rě_Dw!:(p,5kvge-|3D$i$*IA#8j넎CH0-h<"]ƺ,[z@N!PطD;w4W@iu}*4ngçWFl>68:_ʁHI)Ӷ]Q-+r|psLDx`DXH2w+wQxsh>k *eb/0Wg2Kb}4أj lNVnr}}NrDt7Ltn`/T5H'fP ~ I:=a9R h;9/x=2F)+ ,QQ~RebPڄxCfBn5AtqZ:$IOc6!4Q;%8b$`l@%p&"s/+w6V 0 Qr&H(Fs}ofg\;p̻%OS`~K͇2H={ >rpGk泝fP,JDz ⦊ '>FKThB݈t7R{R.`(6\$HIQVS90' 5&{5d\R:J $Gb<@@KWᔪ,zEEtĠ>#ƀѥun(yME!F\<8PsXV.QdXZ׬.+cm7H»{]7 <<##:]DʳF\ .羉*\}`GT*b6a 50 -2P1&j6-Ybb.'aeu' 34&C3[EP{xPاMZ;X ]($s\\p,m$eQY6 '\q UŬp.u޺`R,uHd,'иF'~8{JƆe7ݯ}wQL1iau7;l5`v7Vj[^_l(B]O4tz̋ @bk[a hB.m5܍(^l x}Pi!ʩ6 w00P  yPeIۨ/VGs@uk~h y$f& `[k`סJ2Fk! |8ڃ!𥮳7 52Z}2?[$%IMb#aU!S)\v\/\^uGL:l_HԈI"bu+UF|9[{h.(4`ǡ9#޺rƢ~ncX_D؏cj !;rGѥa(:gmm+ b7scE-ָ݀{2pwM D^;[ P4@ :E`Ԍʪ?-apalC nl 9tD%_]gQ{_4W44F 4Et\Z[,7 aܥzHK8 F$ֹȒml>FD[jԲW#Ʊ)] _rlAi3:Ө!l6 H5+29US\ҶVk-UV녔_cbې{V-fj}o}։h ]E ޯˊ T m+Lڛo5UIloSUן\7_mޱs355@ӡkp.`q*ʼnWmGhoWyc@37y!tmƱ m\[5b27a{q1(Af.t7M0R@RƷxl6ݥk[BC,)^vBE#Ru  |,Oq p`!ab(= BoG"l![busMmc퐯oMm=Q\[  Z \2b#6S-H)-쐪xT{ 6>50k _MLovhO s o|؋ t0_ThK"iv[z *L&` 8{iY>%c\Cvb#c ȩadm4rkEp6O1*FҧZMN󘝳;$q Ts3D(B EE>!1 Bѐ:$L Gl6ft3aCsاq΅^l\B/\E2 X_!ME tA#䁝o]|쫨ܐ+ 3f!XL Fb4k /r1{uθ| nPY]1r@h- ֺ?5k.sF:q-'•c3 ĀwCG-bF(4avy$7eF'#X#{W7 K$m;zMQ $BJ@߾AK5Ε3/yJ:4V&חJhhnAe A{`C,lz&@p{~`J!$3eR](^lX`{٭\6RT=q&مWRl] Onx6 bm_E~-R -InةEpr`A[DG*wxbc]Tz \Lmt>L7Wy/R$Hk{6|܁0mnx|$bI-v udI͜`@6Eg *u)fѬ0b:MLcf@7ntF=(F]Fe2l肢<;5a@/^[Vj9KV7D,Gv8AmʷbaV֞F͵衉~P 8sYs^f:Z'2ډ r`z"y@#_F!XD_ƆB܂r@/]YrG]i_G(Yv)bBIoΟ[Fݥs+XZ_Ն"GK-\] MX&ke$tpbH :2Dcp#ymmQXE?@f2iǥ-ůʩ#_>q"䀛 c¤׷8g#=Լ0À=jPYrM挐OVd& 9kn=%3)lQ.C-P=ւU!6.bN$m~_|\JBE eVu$9YoqR(og#خRS77mx\+G} ƹI><#H0;ox66RE6qoqx`Ԑ|&q)*{Z(Ma#/]}Wy0+;ul4TW̆Yö*@cJ)dcR]j<ed?T `Fk\Vܰ 28}G/qv2D )ck#0KɉO5WF 7 7<Vb19\de:QƢH%,s3q{d1β %nVb9>7?l.g+mCO;ٮ6]# #6xbwgJI'UCn%A xO+I'Am„|PfK a^ ۮ-`qHbŅwgHO F0 \ǀLܧHeFrҠG$ݘ!Զ53|o~(H`TێWq HN۾Xy-mmsOC,r EžEDgd ⵌEe=v^yDt'J-1r^/[ϮZHg#)Y_γ1B1# >Mn2uE>h\C_ЁLdL&@-](JW|Pc Ţ:YAq1nt_ !q2)aîV~LA4-lf4pc[MHNnl}56+G%YH5mO]\:[qr[)Ck-e&]V+3cı;)RP7PHFLJ ;W #a(ڃ0Hap|~AI,&y/*.<17T=#j }AIBᠿ 3& $qTX+bbkSs#Wx &pYZさ@e6+*jiCAרkPYY6TCz[H\0$9$H9@xoDVmnm5\N +ڋ<~Z-ls*i6 { #a_b2(ɉ^o~.QOz9@܆P5gZ%QnDyVLqwTvl4`19?m`0>MIꮸrw!u`N^s =Wz# Q%0\<\y{믰UR!V7x})I%7i>5ΉPF b 2OiE(۪EIBR#@}%j04 ZRˆ!.AU"ݫnEFb`AvmnXHSPꓒ-3 Del?9,6fU$lZHR3(.9Aѭq'(K&NB{5 n[%bl8 T`}-i-+D)r)d9$20(\ ])eX7 sKkwX$8;\W]_28QI^G]WIG'n5'C 7ʼn/ome,qP+-f9˙` q$3d7P b2i""v Pr8!dr[eAaD`✅lHuA#-AV9gBxJas[aHFfiB8e K3kۥo)DN' [2HJܴXT:{(σ"ws[6[{k>Sqkς6X1 2Xsǖ {/CAHnz.oݎ)^ţJ8ڋ cmN0tV_MabfZB %!7:%5HcN~7sk4ʎnL/XH e` ³'(;|n@}Td {XZ}nfʦL>vR$X9:}E =(A;^925pIE:WQ1|bxF o>(sjAf>~pxW*Q6 ЬƆl3,274줦!ƌaln 𮉅2 pzo_>+!xM/V0ٛBC>ƇL<)ko5jas<΄(.uU!T`#@ Po*yFǙE7>UA|;UU`\־1+Oti,usd0fg| DYe`m5!?/"Vx}͔Ugy ]l}54$<̧ٱ$9ZCkt_FpFSk]pFmX V&bͧqZ,0&>Z.)@ ڏLy Z3Hlp e\G~X>;1DXe[i{4 $-xV؈R,FX6l2*f$ WEw1 A{k)<VF̺v+_s B[f nXxDJsbؒs3e'J T% Ae!1Aҹi .fUL:pr\ s]KbpE}j0! -ksfѧ3Vyex24L3fHn5A5ٚ[bz7RG(T~vDAU* uh2`N]9\$fR/hgLBsv^ \b^8 6Zx}sK=؀"x@oxI!dH 8W4eL@U{wRɢy%[I:i,U xQ8 jxVCX{AB=C H̥MqBũ,zRPnSh21Ee{4 f`ߤ=SnF."W7ٙk^ZQ[ CHM"i4+3tXl#8#rr `Nu8 5(yk )*8e ǎ(|lG Z֮uk-FlA:Q8S86EDž#X'4Y[.X#eźߝAW\g%7žC-0'f&%-e:>:@I0˽ﮘa0Vb8">3[)J!.kHIh c( zъ_z iؐ3}ke󮒙(K>z|Hr\[[t"PNX}x,t\g,U[5x%c`Iz=/)*:R`,:XN[X85ۖct.I*zIQ`~ѻ; t\[f A%M5A!f6B$ V yYC*&]D6@֋Vj3綺!YZB~-kvZbaX7&|UdE$ƺHQւ\͵kש*@(=㓑 ^0u 47/:77ں4I!/瘼qmlT5:7uf$uE#Iw;#nr(:B:,\gA Xk =rǚfp"禍FbT\nwpWXVlLca$*K#q($8 )z!$jNomwlIſ%y$sqBt6'J@o2G}s.8;ݒNF;{裊wţ.6,A¶֬p3 P135ߝOF!i|Z…L3; cFe]tcb6 ċ(vm6FdV8&i "l]$!*BHJ+4k>2YY,]>ċ0BDŽRI \ И̸׎T-g]q ri &Nr.‰ @ۛX8SY5l_9}% -9n'ҳvadmB\$ #ߪPTf+QyW+"AյwU[]Qf8f.[U<)nHuU´i̧Fswvf!];Zֱ։bHbUT_N羌%C L e=L#8LV$Z]e6pHF _ϻbovcբV„I燾c32ek*p4/u8bJ=NOvp'vf8PLINuȟړyu5=/RBV8P4dإ*tcfap;. !JYfAq#Op7lp_>! GJZChP\M#EI2c~mǸG P| g,\Ut& 2˂Qguѕm"O)t-|<*,UHTefXu ;! Ay.q|)1VSX8jtGa]s#"%կm6+{B{ٸc2.UXkoQ NNX7:'SyðVMy%2zŸ__bKԥu(\c>479=Ӳ uז> SUe#Z J,%Ƈ_,Ū"5W\?.Yg9 6amkA{DYqNцnt ^)v!7i.0ime'@nm{Vbp&dd vHW2ˠ"Erg.PVi5^hk#G}FeDɅ$uH,T>uy l H6,]8S̲{lVhp#s޵ͪ 87Ӧ&9XGO~jy<,P7Xk2dc1,ˈ؋1F<9A$SA1f~8!` mp!Ak3us ccp&7׸s٤{fe o#hб(ubSQg$|DQPe]J(d+Z+4 A?+f{ 譚ǀRVגp2GMPhy@-,dPo1]#B/9Fd๲Ԩ=-ThjAq3:@n,Mc?1V-ewѧ :]׬Z ׶۝khId$۬kLS7_ k,ىrXuWhR=3Aqκ7 #]UThNyh\(%;]&9u5[c4XX0nsZeWԅNAd cZsb)4 SI1FDá?&O|k|N*̂F|C´lU`mr "b!r3Jú$H9׵6@&6=40 I6B߈<=ՋaWmHBZBA5ՌN[K*Cѱ"4(f}k+tgײ69GFFuN=5HQ1/Al nF  3^YMj1EU.E()zD顱顡1vBhrMǫ,`o~MU!qƝCpkE #f#Qs|SjH9Rƺ"1e:CrsnBZ)ċZXX YcʼIb/ORcTLŘ[XXRs2'\HObD\;8l}o(?ȣ zZZH X%DcYFƇ@$b$|j|&"(O'DE`k^bFĪDJoKNV;:v] :wֹב6]i'  j#˧y@4cup1l75PokL[B<|A͇x#Lp bsŔD/Hr"q~+6:F?8׶34.?^ o\ypY vYNg@yM OknLrS  f;L[bˆS6J&8 *1u)S;zCm$i4˓q)B@ibIu+s3fL[oﯢTs)%%Œ ~Y$B|0Rlg'9攑Y z~ot?{])eF+bHr$s\&m=r._+1,Mw,ٍ}+b#uW AI7)ѷ}Es{'ZE ܹkzN^B(c,ʵrv)?4LWc)iF%LF~ uIa"=d#B,q&5 YE7wd.t23#͕:7`.;u- D7;[b-fī@Y[)4XP +m@I4s`:2p;hm]#R^N^f!A+b -/V&I"ߺTkAEKsSlAQˆ p#}rswRHA'_/OѺFo׮ZDVЌz;d`H9+fpr8-S I,D]~BXIYJvdʈ ],wSsXP@~k(^6'Мuz0Up<3.;;vW3^#XH0rzGAUb "iXۈoxF"A1W[wYDŽVq<8Аm7u`peFP}aw㑟-f_eWY0X7ZuKD8to/9:G@^rȼ,$EfHTm;sW" Ό4F+RHVA㡭`4‰0ˈbnGrv:s6i4 ?b4<)~'•\BnHQq@j.cwK߷ZD݅{0,k'>vszFAc߮ۡks\Éhť[i@-shl2}H`ThDɭ$ 5Mŀ=o)[a#XʂzHYNtK{{뒫4O(W{ ` 2Scom z\JED,ܓʸu\Ƌ-z>RO׺L/=>l) SbH@՜%/qp:[)::M4Mס11s$R# qD،J"R-צbA.)<[ա֎&|jkJ bA&eczeAgpsgE<:k{Iy/8ssfyPUωMlBf(h # >Zbewp,,ֳm_H$+A_Ek8I/U |kLoۨ)ni*MECk8\.W@8t\ωƬ\|bV5Dг*YDkcڤ|q͡# eUCѹ#FaGr<ʓȲQ@Flτ[)|&8,(,D͒~iE\RsQE7'0|w6M^46[= =@јOi,r9 1 v]"h 'h:xWSaMD MAk>2􆤁o´AcqaDzFPr+DVBۭ @(Z7'{%BYT5+XՏq{l(rG:K>i.Z޳8ad\\='.tж Mp $#He[u&̨7-;؛ 2ŃLX3L)9gixƸ ,;qk2EAtȱ<l ߎ5dn4Ll@<^һHRHSbV _(L@c^jMYE]lh. %U0s3 -[I Ёc-(D"zN|a.hZ{$"Ȋw}HHV\($[*&"=D:t&6`8 <+)].} v2ҢX"Z\8l[FL]}VxaoQ1wN ގiDdC (eRdB$'U15#xW0ADkuiH%wWx";&4l/0}Vieƺ-x+ut I&kWp=a:Y7+q] rJCYFQbk.\衹m_4VG֛ҘM0D`1aaЕ :常*r6)Td&<VXCPaY` kփ`gaԤ@u}+kjse[7ߎNL g'2AR>fm2ܒ{4کׯ)0˯vFQƻ/[߶nW\v(ap+ (A7.{wnxezΕ%v(Uo>H[F^n޽Z 7 )&rϴYn]xNrn7n ~FFxs]-}vNZ$eպG}/ *Z8& #yrI*s~5ðÉ5P:`4ֻ$cRYG 891JsFAM8aza"a'qs+z,|pkoAr|0qHBQ@A̗\}M`:FA.uSV Vq}%@!#JIVT΋&cׅ ̀6_kr5ֻ݋XIXέ{쿅)1QaMMq!GlBVaXb}a0Q$^jk0XBq f*y nbX ^4F!VA}Esxm0UEw+ |fdbt*-+qN0v&Jkc-y.͒1sk]݈,Mw\ˈm,4lueXvk]X/n/W,(5 Ɋ7 Y8Ucvkl7[ݕWIM)xv@uЋƻslW96۰.oiߤxZ܉<6WSpfA&Is!rXE *H챱46"l# fQZ.Og%Uܶ(BE"vdgĩ9e_pls%Qq. <9 .V*NEM+ 'W͉ s9AJȸ%xԴrH,mwOEBKq{ avC9@/X8,V@Ćѭpx´BAUeX9N{u^bS Z"o҉CE*) љs%`I_ xLPNw QE r EW,I 8h;$)h#~2O>EEYk+l$k^4A!svV+#ʨH96I߶ά˞=<ƒCPa־|G`Ìd@uoT'1={#o ͱ+^2S"X9|<0'#@ݥXH5!>ƺɆfājѾS\!uѳ-w y9r]@SXqZ4@;ߺuKQFaZ4VζVBkKD#2Hd7 5/Hf r/a~}|eRbx~՛ã5nPo: qC>T)gΡ͗0p=Tɓ*.{UFt]FҢAɞ2>Sv=p-տek7WeI1X&&|L'S!qӼhl;Ջ/|qΗ'(g|LPr_aEG9hgC÷\y؏W4jj%V3G.-3$cnzlys%R\)襮4v9c0q速BjxR)G(Bn1 zKG di#ʼrLMm[aX U6e:JYH)д2ܦZ.gǜukչƾ`:hھ|4'd7]NLD`):ץvr *@= I}aV&bw+2۽~2Z{V9`/$ 5mjE>l-H `hz,000^hpx%R,F8q$LB;VwbQ'';s[wVK#yLAF,f{: gTYe ŊY@RVd N)ݮюV7)VNF`K֞>IQ-In{Nhi*24uטV'8~mIFWD=c]Ib35L~BI` )y4ku_pc,U\xbG_^]+IMm82 6Abj}]wM9#pn -Z.S"܋oQW7ae從sZ,9OwLEdXT"n_:+Xz)>x='>/͉nNCb {EJPx{K(0 ۧ+ujPNbU湲N"׮bTF5<0P25GzĄ'`t5*XH Y 5ōmv%KkhhP7 +X\e75.PP)m]a:|!e;j>B4H\3YŻoG`$p o$PLJ(G3ܨbuo2E8`\Lm}}.üP:Ğk91H$]I4dAjiq_EzژQAq1JlBknYeH؄OhfyH.4}iJ|;VڝC%g&"_Ilk+c,q}aIe$L-]!6I# bH$]s:= 7w|XՄZYAέ8"ŐzSɐ<+¯8~kx.hhB%:먿x{t]:de]YIתƻI7Gꮬ-my$ G.VrD`nOk@ mlXkD$lFg1s9Ea߽c,Wm!V"-=; (Cl&vtScȠpȳ!KzT ⦔)Yd67Vn"Axc(]2PA x$L5h\i`ij٦T[aS9Ǝ5ʮ]NcIoQb22W^Ev繼76ޑHqy6"XX26Chkxr +#SDE*nb1Sș Uruy}2qqD*t>Dk.ZN(ycp&YM+1+wO,uY6_M~1#"熚2l,,x NCE3w7PM2 Lhs3ĎL7ƄpހFa 3-TN־!`+\^ƒrxUm',CI rYo1P8֍;ynmpf5Jvu֊))Eq` -mK-}8A a T@twl7&̘lɅ-mXRP1I"3fKLۓb| 2cxwΛ=ΞxQI{KG PE%Ne 5$^L'd+sD0E kNG.i1W^tHBq\X150= 0rk4n\ǫ6[u|kJlD؆|TAt Y؁jc9@E>ނbF1FK*1٦l\ l.MYUV#9yqLy0IC2``8бfnbư 's8N [$:pez'cTb}'nHwrIn]#' U@ؙж΀DZvX %nd}!1"BwVt]^mE+']V l2u!BZekoSqD"!|V$KoX)].'.C 6=-ͨ9a~tݗ&CX4kFr+7p,jLY=8z ` Ѿܥ/`l@o]>% Vg#BIq"i4f[[Pskl=N^`>N XNvH EmT2ŔvMӆ+ H1<|԰ +I0'8W@_*|Cjw8ƛa0>N; ]@, :MU6}OUp,\KNt;u@Rr)HOt gEQ]&H%IV~?y!\f _WAV>jKkLR25 o@ȬI5rm& koUuV1Ks׷QXybSqͭϨη,y7d`x롮H n]#Mi]ec"KXpCk+$1P AB~˨jP أoqe[˗_ٛt;o#]f:3,c26"EQoż+&^ǮcmHM9>Qʡ0WB6QL*eȷ*=x!PW/E]E5Ga0$ 3f^Ғa]sլ8Sd&΢8d$VP kX@@&ODždrphHrOs #ñPb|c!}@JFuX9nwV$snj7 lj4myu,uߪ(ٴz`m8dhpc#)Nxr؃Kq8Gl3 j$rYTú4-cU8FYX|J7ѱ&㎖W7ϨTÒEb$Ar ga^,F*av бv遘)N $`K܆]f@9– Dk&rpcHQְؐsvR[-E*2mah{2᠅3Ƥ3X܃b(Ӓ-jIJQ]k-)؊<$x3 Qԭ@OBV_lDgC | 0(BTzO1HJ#-aC!pl+fSR-5x@&8bKex(㲜"Oq v==#Cs᥁FSH[ U>ڡ8vStH԰:UsR>Ll˨I>)ĠXXC D ƱPorKVEfPؓY$+ i &-$ws{apWc}u5W[bo+0Kl+ 'WMvU2Mԃd$C[4nL?™pJ몐lEŅ b%\㱼+3+kAÅ"!Y KB$!-}-և8ى&ք:ed0k 2l1ֻWBâHdnHvȤe69,>`7􅫖ںM#]C]_ '[Wɇ&n[ƺ1aKVS~Q0ao 9:qN1m+A5H,#9J"|$g,aMW̍ &cd>oQޔO )5ʝ^J)p5}j"b{q|Ey3@2QkGPS!a\8`ͫ)O֪"?hb?%C]M`,PhM„'jhhpq,saOr[sgͳf[57F'**=o‚T  ^5`No 40i r-oW  89&Z]7)N$=R(>F!¢_gkqk]qXh\gTe'p1T9m ?5} g X qX*j/jdE[P  ɚk ,NbO^VRPQMx4~) 8Ԋ|DlC67=F eB. ŤU9t&&GG}cA-_^;}hD!H/'dq W*WcW]u%uwlKKkVKLB"}Ɔ,$$fD,`k] Z#cCr a.S[]hn)qqYbceʌ2UG;\!xZA1go\ΈcrMqqX$ȼުg'2Rсfa0F%P}Ru(4dBW(Ӆ/*֑3uR)Ke {pY%OʀةC_tN߉pUG9ʿ ajX_67߮2ٮ@6J8vu XeÅpfP-g6[O  2c2ў!ZYK#Y\Z>R)X. jte 騢.1Vdb5>Ț6Hk}m6 "r!Ŭ-H bvҸp<6`ؚ\7 &oM'>L'|6qêf~[c"a z[/(ʲH4'[5C6dvN:U 0FPRdCuXMx za&T]N Pɔ77HZP@ sz06 \=e5e3B6 {h1Htwl;A:u\;vI.tz3V뭰JFշ ) F$P# Gp7Cʼn杦/#}h1QDY [pR6L38,4jZ `dSn5QFBfFFVP~<+4b6}+s}WQXrMu$4ڹ3hEW;uZam MX߶nm6۵t-J<+0 [qj_ Lj5³$PrhMsߤu2?a a ږ`CĬ1Ncqi b8uWrdxjm\{u:t.\WĂ|8W$&a=B-yln+00mVbU IDK XG&<*YF±b3$-`#$JNg)[{ލºK0hcWKj S)*2nQLrn&]ߚ=zp wQ!vѢ#)#P$\Wl[D#t -p^!8b}B}6bz/ |7nX(&i&ApW9/Tp X Nx:j.Mu%nB/ҿjE-mK94㳋qƤXHi͉qiqA)Qst՘'|i,ӁܜLȼX~I%d tX6Mhx#7 :fMkH,t^I;06SXy>, fI0ָ桄#PŻ 6? b"; I.Ws,qNG-Z t^ ΪE#}EyeϜ#>D}V8YmDw'cS22oHikBI#vNQ{毭i\kMҐIcmI:%HtC.8@yǨŀFWNW}V2rTf/(QNe E׾`r6khԓ_]5+k1< 毴〮GYI7[z`K[_;HMէm|l鮷޻4 qIn$i]af殡s]e쯯}6蛓\**/ö7وOsm*R0BL_MJqE$%m\n[g?#D$Hz4LX^n 3kh4.N|=DZ:FY쌣RێG6AUR46:^᥅(oұAt@]$aL-(Hܯ$)n1ljlXxHDoij\f'$}k1a܈݂ޫQp 1b lmeTX1\%`ʢZ [쫩'M,=u6޸+u  4ӆYTWupzG[dMר#)L@'Sn4,5CuG'r'pRH4q{9g q[uWiBW޽b(t#OKs]n/"n@쯃 \부ꮩwY Y@W,C|nrt홁;x> _{޹atz]Hho]Bt=^gPE>ıq}lHWk/ XbYFނB6 r k]wuW9FЋSAna6n+ݛ3fȌ_2߈5\c]e뇲X_kV%oIr I vrrkDuJ~Sp+혓 OOԃb 6B\#[W!\ jm]eoz:(F!#G:LO|+DD8:P1įXbl"XYJiY$]]Xܛzon5ȱk 6n PE 4&ڹk|loCd\@U$)|(̰->c_|t$ Ryc|1(Ѐ0'5Ǻ"rl/aZ2W۶ cNÔ1p!8ɲ&3n5`Fjk@ М2|06#][rf0'sFϕ"XYnEf*)t<;,F07ӴPYEpds\ݮFM֔aJ0˕FNRkpYņ5e@/Wl`nIֻE{ Z&Q[6{ ']6޺2YG#SzѤЛ+;WSa]mn޽}rz<7EswuuڀP>rsfǎՌ]AxvkcB[F2}٠}; o(!CKťDX43MfCb&H@7B "ygTrXOÍTCR~=czˡf@,.m\(\ k}tW_K'XquVbu+A'QcE?);aEMjڻ _]v*c H[.+PbԑՌL͐nNacVuXQ ðn\ʒr#]=|M΀!̀ 0h\V3!6o$rxlb m1|Fy:mk z͈ -c\.u `k@ͨ|āRW t7ִ=t֤sHGQɑ\&Զk-nڞ&%FDtaCmskZcbmp6@5G^p`xWL׬K֨\@kn;+o`s[>kk 4*WL=U|Q(a''dçlN(98uV;\.,4K.*S4ZFܞ A^5-]jFPMP;kׇug@F]|Tuֱ/GҾi:$CوEz"(QڕLo"BoX0D#{+A+I'\/(uģoS~Wﶕ{0v#\ ,ױ>stream AdobedC     '$''''$25552;;;;;;;;;;:   R#!1A"Qaq2#3BRb%Srs $&'()*456789:CDEFGHIJTUVWXYZcdefghijtuvwxyz?ͻcznȯAI;hren5pM5Hk\Q<(jn0+|Tȶ;P;FQ6Wd!n\E>C^x$x0K<¼=: Yç;;3hOKۖ$+Nڀ4Nl[kC<_S 6klxˠrmZ0_&J }aBO6R{NSFn3wrGPvځY> pM%T/ x32=rJܮE",x`Exs$7_(nqǥ W@3AvY%7^nė|GS>5m)}S^jE0,pkD۝Ģ`ҶY`3)ӳOa\!j*\=E9+:24@"}An$йJN(q>2O X0=ze19uȯ y5*N@GA[@C$P㬘k뤎M|.wݸuWtxs#d;] Ǜ <6ͽś8py@*+X[vU2p=Cqo J,.L -Хn)5v嫆asX߱yxGMye,`X#8ʠpE'DoN#J)1w"LA9ekbǠ gmf1nP7^IU]z*ٮPe3`*6b.D_jP[q W<1׺fA^ky8*;'6b3 &+J,Zm]U(. } ]2A;|&r`Bǎk>'5$kFҐʑ_/7ݵ˩c+ xiqj! h*^s';֚! مDu WHJMۀ݀BkG9R9:@`uKxAfT“j^.] =.^E|{Co[!߈^S2eA}j; y`Nom|ulwYv _sny+q,W|5O5 3GOkiIh[hy5Hʲ=& ub׳quS+6 ~Fà Ag]9|q^]H$^yGRDu-<70|B4m<|־<&^M\$o 9:΃֬ Y*:7)Mbl{T<`SuFĘ?%J50JPcƼնH=|Cc)$| K֭\o+1Z7S7.޷sn\Xͤznc+WEy'us(.'];kekeH: r.j@pXawAҰk.<}{J;+ݑH=ΝBԋqa B&L\+o ogs{dPm=V oYͤF:)Ӯ?جΑwxz[;|#F`qO<ԞE-VxBS1_s--̱RULWUۢkY *YtIb°6Xttt>8E70eP| :ZFf!+D|ZiݢIw, +NledRtǢsa^_1D~3kvVܩ;U~3M=נY͡=c_^oORbқÂ{ t&$۪ʓy~V%Pz5_IY:3 3I52٫΋S:>Z% %OkR$N}zƺñu>b VWƃCՏͥccNj 0oLqXM< 5`+ɴXJ95\.T-osq؄FnT.03Ea[#9AE-c_X1כXHu~"4ƀr u.c&qz 5$:qw:XѺw9Dzݺn)';&;"bTÒ{X]d*Z {Dd?2W'78wh|^\dCg /'y?ܵ.S^C'R[mk窝m7S-D[@I;{g| d,k>dq-jnMt}^^.G7[د D=kѭܦtfp,g ug0>ӼY3$^AN澇Lo ꈏZ.)z$W[܍,Zئ?2 J.fm|[8~FfSm Xn`Q jw >\z]}(峺I&=V.]UDKd\7ob Ax?^rymy{5.\ҲF&ǽGx`svR e"`kBNe 3׼ "vPop- 9n0tʢn[#^$Dp{>s")'>'P4] (fvJ p$@{s .oO e!έnLt)W qCzsZ&nNH2YVŰGL[QwH CjYC\É(0^RmGKu,$e-Y\3 h5=q^zZ+o |L\{p_)Viθnt :h}z WdYb2OL۸ݻxfhB9ߙ~r:b<7+"ҙGrM{'s]Fׇe)׷O%{B/GVVR$Ϫ>J0<x<[zLw]cl. prdmfA&$*s ,&m{Ry\m#1׬+HxhL 󲁿[k1:S[* G& $O[5 SW4 V񯏠y Ȭw]\(w-g.k+Ŭ2WHG Be؜q2ki⬎+&gn ²ucR`sHݜ-ܹ3iu&?Z q|bsnkͤn߿l 8RmO'c)Ӣg>P)!kH+d,87ǯ6X߯Kn»2*| WK/Wk=D{g2-źù9. *0o׻^ns7P;=q^-*qL{nesRKǫqY[C:Eq{5s]D!,jt)0=2Ioz6bHOSh~A&b`|$בlrC|X *NJ'Y:"4:PO/G_^f$r,m ċHs:>_1κ="gݔQ#Sx\P*i g©60rs0Q򗤸N/_7i/v{ڲE7 k`bݺD J-dp(xhrR%H_>YRs'=+ڀm[uG Q^b߸\ ܕ˅G-lvrolx1wk7 $'6̌OO=T+s$fhfTF::n+n 41e4㖽湝|f"K#7+i٘+(-st<"קPئp`t?)s>*Sp(;":znq4wIuϳX݅n4UbvepgyqRufHmGUs]qzW.9#R~̵f5Zs(y>S&nmXYfum*hb-( }eΤk\>rU4^-)[c,FtˠoRfҿx]#TмKs=h2%naXUɝ^; éeS 4Րy)#3sh)p,-/Ն=1ǚkx7\ K 1ȓW:Zq sNǮ#YpYw?\yC^+bRb;J֚O:fP7%?%Mq5n$Jn 92}c 8Kf+X%-K L ɵˉjg3Ka,Cj-`w1`ֆ3۸Gt2Q^.o/\n_sI-5璷pw2U:"E<6f1f#| ,]K8S6yG!qeYhґb kJ*49 QƳ#0%qIa=uVpDtC#6@rp@1^W/r5ڪ\Oqw Qo:k؆ծc^Z5bݦk]'4oˉ&+Ŭ*6\-`lxzatW!,mDͩ:[Vk('¢)eݡrCZ(\ &}-uOk,ζ O@GX3զ%7[o`1I2:\qn_lKP'_>Z sss{Y鸍!Z\^nŽc򖯊;KB[.zvpû:"xviv9BuSex]Zɋ2"q l=z"7 8kbى?[c@R̢t@UL]eZwkq |a:fy;{ ѨxVjʣNvʊrNPXUam4 `h&|Sy $Zp^|y19&)-g<,s % 3!P ޾NV$,ǽ!Y 7a}b`#x OA)?+3XbO*:a! sݻhۨutVtE,sxƵÐTҎi6'qx+{jw|=n ږՎ@= @+ 85ۚֈ5 C0WՃ_MfTk^B *,4 ׬=ɲD5 x'/hlz o&rn2zܿtIPlV\bA.jZ@P5ӯՑ ޿8.\磤|kYu¾@=|F1 SCFd0pRf=qEV^jw>s_^:%R| 7qS_GP=jFQiFg%> ׋8>GjtJn97%̞Z~QcدoqÜVYIoÇt{x9)<ܢ* w MlkͲn=ADvTm>>. Zqݖ9=ϒv`r&{V~dcg&1brc&@QjV~ ח[vBP`t )Fmy!pDrק!m|CGɖ_;[wWkG)1Qc_zڂև_o{%xkGեz%o)(gYZtߕ(Wr-Ҭ'{#{{ܩ-A-iî+janyQ"AK_GؼHy Gn. fH{HuC _B2\! qOŪ,)F7lÖ.[]U4rfdt5B,ĘBI:i嬔sqƇѿ_o~Pהr䎓Q 2A_{X;b :ԩkkN-4ͥpdj~WF̄x$\ Ӹ׶mw {kl3W 0\3LeU{1dY:ҼFԲ@03AUvДȐ<Q_N9^ʭBhe֣Y@ zՆ+g\!nv^l dݸLswװ9k͛en=|u,ǮгN诓uyHհe<+"rzoִo3o8 eomqZQLe ՝{^ol%`.&='A}K ,n֗[6;]=`) ꨇH2|>fkm;xܨQD,̍4=jgK˰Fl]`C/*+ Y۷ݩv I8uiDp,9h[!Gx੦FUPL߮MWl s xbk*ROnd4]~6m@$R7pfm͌0vnϷ\VYRy^7vWcݜ֔zXb(HA[%{] 2cT__-%y 3ӫ[Y\>`y֣VyiypM;}j'O O|O>\7 c\X`#$:r&߾ʕ:q7kShZ7ya&>8T 0Wn빶@}v@Yʉ:;S5UG*pkKp,N) X8a}V!IH2ANWtߧ;|Q8tePd`#Q찔.`Gpt-l!Il[wה9Ǐn|pV= F)_kk@n@M)SRQ%9Vz:i2<~E`Z(+읋ؘkb8v4Db^Si kX$5`TQX׋^`J|1-kh1"l>DhsRdܳ-5F*4N;sxoA:Q.NOTܕ T=1_<26|٭vFW<嶖S zA ؑݻqsz*_i5ژɪ2* K":yKc uA߹:,z5ytHq>LB8ݰ'r?YokR7S1}{K61q}ři0d]u9v|i?Yշ}OXY~T3qw%|^k0;OAU g(#MYm-jսގ"uaٚLvIxطs8$sa44NڛWS rw-ސi= gİnQXftI>8{LHuvʁPO~([qJu@r bmBaKw #D`Z;qh~fϥv/jUΤ:+SlBfĽѫ=QD(4 an͘DxH;N,XW$ #Ǿi8ݧmNG {#o&`ݶYWk7`Y2Cn6h@ѯ й@'u`DhuYO({K@:PW vq"sMhF%LtL=tYQLx8E`')צ-eI ki^~I\֥Cw{w pt@Q+q0qn4f5 x\U{װKռCmtuP C ۛ4ì&ګBƭ|ϳ/0ȸ70*0Sۅo.XAmE xS52e36 ƴ ]LM׺ vX%k,N)0s1[v,u.ٛKUl\k{:#^ثXn+ hH Ye mFqfY,ɧc#yk|sgDb0զEu1@kX*2X{_- ..Pf'(A<6[fĬj!)3Y\\^rp9ns1mĂ☶CL8uڗ @7W،y׮yr@t${ R݋x5QrF.HaUt$HF3~Edlyr+˝ӏ4Ai6D@KYIdN^1Xg 匇P.XS.5k[xJs$0Eҳ_CܬkѺgα4e$xUrPHSAfx (6;DiL,ao Z-Ydu\^ sLM3KH Azz.)KI})w2Wun_o pߩ[m\VcIrwrD?ՔfHRaѩ\n@Btyk{J朚 N`ʞ̫Ba}e,\6쓼XŐ>xuԐtx7ͬ6Bn'gKV5ƺ7; jw* X\?Z}/r10* kEюAa/PQfmKiav۵ۄTZ$xm-َ2]\U9)8V0X2[gE؄\!.HW^w+6#MnT6兟F^妘#zwRPrZڶ,bژB̺ʫYE DtTSׅAr揄}U|s Djt4b/7,]ó0|YYIre9ಖ+m{ rFK֎匑l\ > wjqpͳjиTo9d1XD)bD):*˒ y [g[%Ix5l7>ٴIi>ٻ H XSvap6P+3r훎ӎiU;%7W5P@mo4 b+2C4@=b/rv&zxonBnR˰%\Yq7m>ӬW3<DžlMi^0I)<{dE6OMawt̰j qă[ard2m#I=B[9Ƈ%ӣwF*]smx2|U׺f #Fϊ{sXhvc-\W}PgNk䭋8_v %s؈+,I6’sIh#;xaX٣kOFeF=kݼ^""U Ƙ|NapP'pDfb4DFD¥7\;xzҵT\]WЎL*\f[-4Yo`n u m9~:]Qy43B#1W-kRUdbZZblku1(5)[KE9 O;0iKdJD^II#|p/Zr-3dU:7=7"ww*Ab!q %@(>:V{-^HpLm_6̕.zc2ZV) T|-{l3zGrH:H#[%^ٺM]3)Nūoj&/c`A$%D;l5mKA tn(Z"η/0~$zmH?^_n){@rvQ@7Q**k*˸uf>n#8S^-qX=lWHZg^Ð/VNUo ĩHΪ}e`5D-h\.Lc2$߯g|IJ& 'SpFWa ϚLo"f0xtam coͤTeS|(r|T/w\"sd tÌRSրղQ:"n@Y+۬&3 RNu RuY"nJV\ס$[`w1@eVm3&b hIi f7 Q~ӫ["5Gv4_UF]HoI8D Fag̠#,o^oPMu"$L׽k$K60M )A5-hݞs5sWؓrvCsOwx |h.ϾIPσ4kű! Z^G1ꙥ[CgpbB38õ|gKػ"27pno.G6.71 èGyq/yFe6nLLp w𬗵B KU rLȀ7{.{.o֘ >!Ud^R-![wkl%7`I!VZ0[2+`cÛW-ň" 5G%em*$h0킄nG^6~ji/ʆo zluVv nI=bbP&~^E;@x螯nϓ% 䬙A2uY1]wε[}6\V"6l]Py@I  ,m|]&ݵD[v m;:),"dX&pv.!Z ZqK$ em EŴ[d.ПZs 6"uPVwdHGWHU0_%ԅ= T5!r bzfz0CG N+œ;֡a޵}@I hM6^|jt[ 1'p=Cq(ە{4Gd!a5ǚ~F ^Xmz5;>'kWpTǢ6n䕑߹μVc;Ȧg\Pױt @{k6IY=_67W#1pV̠GOKqF i&^W]BPxɬ$5+a^mX`u_1Iw/1) & dݼx+qUО֋.75I#tkay"DfQwq{ı{~D8Qk e.(o!c {(d%-әf>rɻ%8[׭En-G)AY=~I>t(QO4`m`aܭ= [ZeԆ\apu+l<޸k!ׯ(y>Zab1K4 #B6жhႀ0n-3ĝ/cnCr-&d̬blGi!Jo\ƾ%e+m]HX2<RZdf:Akq٠Ҕm،.Z##)$DV+\{wLW9UHK̡'14;,n7z98СIǬmgl~s!Y]'P.K|]1nLUXjwn-ſjV.@Q@s{vn q$<ұz+#F+Mo;c"礐É/. ;ch ɘ9Yq] X t6 =Lp*^l.r:)l$M-'}Ys0ԵM˖MOoQie{db ')so2ꃭggkH!Sƣ0#_{O{OH3WrCzZ\!Xܹ洧)vtO˕Mܬ滚z# {v&ƄǛh\VVӔC7~kZ nݜ2r=ىfui.:فݵYHCJq8al\a*9z6^8{b0s4#8˻Ua=&+ul kzum{/j]tU &cs?C@]]ז~RY\d{}-+L11'_o5°H|L:Ik$spҽ+"bwd[ c)hO<% P{BؾN6e);anozd+o(X1t'NJ-9=m'_AC4)o') ۸u T;gׂIߺ9+\-n_$Eu 5#H߹PWƽwNXzz+;RDo:xKd$y+]9l'pv^07XQW]7ƈ{qhrK;+El6 dBUe'Jn_ sBrDdM w}y4F;YVd&kZr^t8;S^^#4 0TGll&Sr{ ;vW<I#QJ#\m  "yr2ݹ$#gr'i q2}*ɝ=Ue$;ZY ޽|$wJ%`WɸO4N@͗A;'w0#0 6lwCtuW>Br  $K6ɴ޶y+[[B\8OU{ V yYBZ:]<4! dw ]:^3ƾby_K4vL]::(ke$׻FBI^ ImѠs$@DVȮ0b oxu3ڴu5o/|s:c^@1<+t[6鬝(l4Hy!n|t={rkٷl(+!=Fskl=~9-/=l3Y4R{ⶵ .'rJs:(|]Fbm=>eE^ ~<{--grVEhi.)/Isڷs|O|ڳqa4a,.Yx@NWf7\ =jt<ɔb߱QxUvFW#(2xQ$6fe;=X"O{qKl?(zsu EzjT(<-m5śxt@2 ]ZNÈʌ`#}{w@ qFXT9K΃XW'Hݠ &RX{Z1.\=UAkrZ*.Nmt5mi猠t⬢ (`7R2 .#+J ˛(vm] ]v3ix^ҙVU6m(d:xzkbO t.Cր!;$Mz}9xiZٶVԱ謱ض u=17 mE:v7nWkxBsXUT;;%R(ê5{xsY{ljANDы3@kKx3xp^V^O _Bݜ(:Fc&'׋ u۷ 8LX8ð d@8^WpܳtNkAp[f:-o( ԉ&iG]u;>׹nZO"`6V\h/:נOB&$NCqXiuJFj@q˷WYR OrAۛyY* Vy3g*^r-Ѩ- E8.VݰkuU|ԂˇŒ.[N+ǿZ\5xbpw#04^ړ#wɰ_]4kI!uѸw2[ɽl V]oζ /~qȦ@R$k;_ ) FLs܎uKj x# ؋xJf[yMvgb-ccgݾG0LDaqp {m@r& ׶B[Run9-a]C{_KYmNm9Det#B8~|baؽX[qOifW2- Md6zn\-bS l[]6~Э^#;↻- l awegZ^I.Cf뭱B,mnCl3v2N֍t&y"Nnj`5\ꭰ!.0mR.1UcV1?NÕód{sMP0x<%-UET h+^MFBMz`i^^Һ#ZpemH="MC2|!eE%<^*-\Dfr~ڃh L[ 2= $Po.{ qi]J= V}] 'qgp#2BP հ6L;~YSl;tEllkk&Fκ5?$_amND~ӽXͻeT}``$*gׯBcQ4e'vBk g &BL VᭂnYƴ11fCnY'6:{mp)f m)v?oN [H#17OȻIb5=&ßFUuwD{Wql2ZnoPYUO4>erݬ$Ö,E'5Qy k Uz@4B!.}$zԮ룘e| 2 ]7/XHqvݹU'VQzƐhϙݳds m6?{?a5LϪԆ۸XSv mGYV\ ƾ㰗$jI;T,Ah5m22 Avm2|f4g16Fh0-4A']&2Ǫ۴n^r]1Tk7p06cN[f:5ܳ+WZIV 11 Kv۶$\B#Z%ImTO ů>le"t=SZ`ۂ@k23A:-:201"Z}mZ"=z.̰-_7ylolTƅXxWE(%@ȅc|=DG$A~gLW/ֱ-?JʷN=oz =Xfv݋66$ PwH[ڱm[7X(ӌ˲.Uz=Bڗ,(TCB'C_k|hX\}3^ f:i@Nt4(@W3 cqXSMvGAb $8 jڶh#vtٯM|w{4qנH# ^յxV@Elv_1,a؞iwF<׭TѦ;kK-Tp+G8Vɾ8nOr :mC p¡pèos-Úm( v"!zd`5Uy"u|u^0ՐnIG m1fQ7A^7S摧x[،[wٶ0^(ψvvӤEcm)Dc*kv(iK-'.~;]($:@41/[sPʉYBo6b]ݶSv dC`^nQqa1nYy 5 Dz8YjWg`n *@ZY -Vr'MDנ0ׂR#kM`k)F&睘ݾl$/.~^kc0U\4&R r,KL{;M]B:&`V_F. 1YDd. -iup5{p\`ډX>?kc1Sgchh3@nu~|fX\i:VLzk5ҲcY1րܡ6g1&A1Yr@p_L5%| /kgձ&fצ8ׂk$+n=p;+ԁ:W`@^pUZIOӥl7S~QwN@c|1㚞k٢6B\rh5cފuO3nXNhvg1mLV__GsdW2l,1Xor]l]iv0l" em$¨&vf\:|KZVT*[6\8q;&l2pЬDikoooX:(́jW9[jóe-_ axLӽ\]s[17nXM|y1= k&: <7VAt l]+d=:DKx:P46#(9 _q˼x5qyp3 Ԁ[P8 fݶR'2#LP+[ݿn$t+qvr;kl ƽ]*&8V@4ceyF-D07QGj νʌ,P@Fg:k’*1qwh[]uK{+W!;O-*[;W9۴ jRUۏz:C }ARQMӚ$w,D*ny[Lk !JݲUN^ {ZV1ro6 n带"DH#SScbV9$B{bX({HWVegĆrҬb{y4ĉFk32;(w7´|@^]Ĵb@:Fkn̽zC֙{A4믄גMxfȚ͍x&N!uXߠvʠ :SO38ao 1Gu Nuuxf3_ q_'|Ế"Gu=U{4魭.8@ PH=&"E/#(< jxY.+b@ ~g3 ѵ#ܸЗʑXz¿k뾶fY9`5妳5hQŽb5uc.,-:>~+w}($ _S1D[Mc,>盏1eRo|ܵفa2b2GG4qy'u+[|sGA՗{+m<5 *X"Zr̍4i;\q8/uIZ[V#}x)ҶKwdiA.ý=ul# m$ѻ/iltYW^m`AaM&b/bcanz.t&l6լkĠE(Ta&;9cg`mPΆ ȑ#tPMn!L:kśgkED!*eXX86n+X]ڎZ=$- c^C"woڶ`7dtovT86!ƣyf;¿6!V7xZC:"Y=Y2u2ϥd_ d_Q&f5G!Rbl2{Ʃv2XMfxy:U릵w k;H"^')$I:+h]E2 6=u2ACb+5q/G;7|Ăж8e =z/|⭔YhGo0a[6c,ԃ`-ezz4kxT|SmbV$Q y~h1%bְyڙԙVhVJh{+l_qȓY ێ&'׬spL5AFr* A ̠!kN6m[Vf!d54`n|TnmF3@{պFDdAֽFz:n[lE7R.Kj'~A ~,@e] naUj)jT5VGC~c}՛Vm^ By7n0+⪝}n H# i'Mk$xדeM~'A_@nݧ|xW`FQ ĜU&cA5\ӯ- j[}M ׷/2Akm*U'|0GmMb6ەn1 ,#xR\f>çBqrRI:tiZʀsYW:Xh$ q"XA,~ۋluNYf5㾖m7,РZ*t0$DJ0_g-\Dۥ,V"&uЎ ׶lTЂN4P®+B##* wW[V`w Wnp?7Lm9r̀+=$x^ x5GuSro֮qЏRC A_+AZfkW{zk|[k꯻x æ ufxVI AQRxQu[ vĚSba e`H HٻjCfF hq8+,So(ta+[I(i0wD s]+ɪy f=sY5ya;+RHNRL@=DPK=Wxg֧X[PJQFU[{³K@A ^JɉVE|7W  85^xCS-\L€[@ w@ I'^@ȬtL20pAf`Vz:h#ZA,z& Q<›[xVS.]&{+p0v՞+L:Je@Xf%ߦ ec9w_Bh2mif{%wW ڝT+Ck tk\ͨh fͼ߯#0*@_J,YSFn_ lSuR; @$WDO,4Íx4מ]zzxS7?֡Izg>񯃺qZu_kN^n mso^pݯe3wIw+-5>9塭k݊^L{wjܿhnEa~/|tx;Va+^W~?E]Ed +{?V-"¼׬.|xV{~d;zk<{W_3ZiEOYƳ5;&Yh endstream endobj 986 0 obj <>stream endstream endobj 985 0 obj <>stream endstream endobj 968 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\032)30(\215\f\215\007\205\002\001\025\016 \215\201\r\025\016\001\220\016 \006\220\ \202)10.1(\024\025\r\220\201\001\025\203 \n\220\n\220: )]TJ 0 -1 TD [(\025\221\220\006\013\001\220\016 \n)-10(\007\220\001\220\017\016\006\n)10(\025\202)10(\025 \006)-10(\007\215\017\013\205)]TJ 39.376 1 Td [(T)30(ubular duplication of th)11(e sigmoid colon: clinical case)]TJ ET 0 0 0 1 K /GS1 gs q 1 0 0 1 42.5197 743.0544 cm 0 0 m 453.543 0 l S Q BT 0 0 0 1 k /T1_1 1 Tf 8 0 0 8 42.5197 731.2159 Tm (\200\026\024\026 \033\n\t\024\205\033\023\031\021\025\002)Tj /Span<>> BDC ( )Tj EMC (\227 17.11.2023)Tj /Span<>> BDC ( )Tj EMC 19.488 0 Td (\n\t\023\031 \030\n\032\026\005\n\024\013\025)Tj /Span<>> BDC ( )Tj EMC (\227 30.12.2023)Tj /Span<>> BDC ( )Tj EMC 18.78 0 Td (\032\025\021\002\024\n \013)Tj /Span<>> BDC ( )Tj EMC (\033\205\005\023\025\013\026\203\025\025)Tj /Span<>> BDC ( )Tj EMC (\227 12.02.2024)Tj ( )Tj -38.268 -1.375 Td (Received)Tj /Span<>> BDC ( )Tj EMC (\227 17.11.2023)Tj /Span<>> BDC ( )Tj EMC 19.488 0 Td (Revised)Tj /Span<>> BDC ( )Tj EMC (\227 30.12.2023)Tj /Span<>> BDC ( )Tj EMC 18.78 0 Td (Accepted for publication)Tj /Span<>> BDC ( )Tj EMC (\227 12.02.2024)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 42.5896 688.2959 Tm (\023\023\034\226\034\022\031\034)Tj 0 0 0 1 k /GS1 gs /T1_3 1 Tf 0 Tc 0.026 Tw 10 0 0 10 42.5197 663.9399 Tm (1.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (\200)Tj /Span<>> BDC ( )Tj EMC (\030\031\021\017\027\027\024\005 \023\030\026\022\021\017\022\036 \022\024\ \035\024\023\030\024\022\021\024\035\024\020\026 \n\t \f\021\024\035\022\ \027\031)Tj 0 Tw (-)Tj 0.101 Tw -1.296 -1.218 Td [(\035\017\f\034 )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC 2.974 0 Td [(\035\036\004\036\027\017\036\n )0.5(\023\026\006\017\036\027\021\026 \f)]TJ /Span<>> BDC ( )Tj EMC 9.195 0 Td [(\024\f\035\024\032\027\036\027\027\t\n )0.5(\021\036\004\036\027\017\036\n )]TJ -0.003 Tw -12.169 -1.218 Td [(\031\007\r\024\036\027\017\016 \f\017\020\n\024\r\017\007\027\024\005 )0.5(\022\017\001\022\017. \221\024\020\035\026\f\027\024 \022\035\026\f\f\017\ \235\017\022\026)]TJ 0 Tw (-)Tj 0.076 Tw 0 -1.218 TD (\006\017\017 \026\027\024\n\026\035\017\005 \030\026\r\017\021\017\016 \ \017)Tj /Span<>> BDC ( )Tj EMC (\023\024\035\024\032\036\027\017\016 \021\024\035\f\021\024\005 \022\017\ \001\022\017 )Tj -0.02 Tw T* (\031)Tj /Span<>> BDC ( )Tj EMC (\r\030\024\f\035\t\b, \030\026\030\026\002\024\021\026\027\027\024\005\ \221.\222. \202\004\022\026\f\024\r\t\n, \031\007\r\024\036\027\017\036\ )Tj -0.035 Tw T* (\f\017\020\n\024\r\017\007\027\024\005 \022\017\001\022\017 \024\021\027\ \024\f\017\021\f\016 \022)Tj /Span<>> BDC ( )Tj EMC (\026\027\024\n\026\035\017\016\n \030\026\r\017\021\017\016, )Tj 0.189 Tw T* (\024\002\031\f\035\024\r\035\036\027\027\t\n \027\026\030\031\001\036\027\ \017\036\n \030\036\022\026\027\026\035\017\026\006\017\017 \022\017\001\ \036\004)Tj 0 Tw (-)Tj 0.246 Tw 0 -1.218 TD [(\027\024\005 )0.5(\021\030\031\002\022\017 )0.5([1]. )0.5(\217\026\f\f\n\024\021\030\036\027\027\t\005 )0.6(\027\026\n\017 )0.5(\022\035\017\027\017\004\036\f\022\017\005 )]TJ 0.038 Tw 0 -1.218 TD (\f\035\031\004\026\005 \n\024\032\027\024 \f\004\017\021\026\021\034 \021\ \031\002\031\035\016\030\027\t\n \031\007\r\024\036\027\017\036\n \f\017\ \020\n\024)Tj 0 Tw (-)Tj 0 -1.218 TD (\r\017\007\027\024\005 \022\017\001\022\017.)Tj 0.263 Tw T* (\212\026\027\027\026\016 \026\027\024\n\026\035\017\016)Tj /Span<>> BDC ( )Tj EMC (\227 \007\024\r\024\035\034\027\024 \030\036\007\022\024\036 \016\r\035\036\ \027\017\036 \r\024 )Tj -0.021 Tw T* (\r\030\024\f\035\024\n \r\024\030\026\f\021\036. \207\024\035\034\001\017\ \027\f\021\r\024 \f\035\031\004\026\036\r \r\t\016\r\035\016\036\021\f\016\ )Tj 0.11 Tw 0 -1.218 TD (\r)Tj /Span<>> BDC ( )Tj EMC (\007\036\021\f\021\r\036, \004\026\013\036 \r\f\036\020\024 \007\031\002\ \035\017\022\026\021\031\030\t \024\002\027\026\030\031\032\017\r\026\033\ \021\f\016 )Tj 0.012 Tw 0 -1.218 TD (\r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\007\027\024\n \017\035\017 \030\026\027\027\036\n \007\036\021\ \f\022\024\n \r\024\030\026\f\021\036 [2\2264]. \211)Tj /Span<>> BDC ( )Tj EMC (\021\030\036)Tj 0 Tw (-)Tj 0.235 Tw 0 -1.218 TD (\021\017 \024\002\027\026\030\031\032\017\r\026\033\021\f\016 \r)Tj /Span<>> BDC ( )Tj EMC (\f\021\026\030\001\017\b \r\024\030\026\f\021\027\t\b \020\030\031\023\023\ \026\b )Tj 0 Tw T* ([5].)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.01 Tc 0.018 Tw 14 0 0 14 42.5896 444.7358 Tm [(\f\026\017\031\034\022\024\232)5( \031)5(\016)-18.3(\240\034)-31(\024)35(\037\226\232)]TJ 0 0 0 1 k /GS1 gs /T1_3 1 Tf 0 Tc -0.045 Tw 10 0 0 10 42.5197 420.3798 Tm (\215\026\006\017\036\027\021 \207., 45 \035\036\021, \023\024\f\021\031\023\ \017\035 \r)Tj /Span<>> BDC ( )Tj EMC (\024\021\007\036\035\036\027\017\036 \026\002\007\024\n\017\027\026\035\034\ )Tj 0 Tw (-)Tj 0.069 Tw T* [(\027\024\005 )0.5(\024\027\022\024\035\024\020\017\017 )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC 7.304 0 Td [(\022\024\035\024\023\030\024\022\021\024\035\024\020\017\017 )0.6(\206\202\211\003 )0.5(\221\210 )0.5(\221\210\025\207 )0.5(\2251 )]TJ 0.132 Tw -7.304 -1.218 Td (\020.)Tj /Span<>> BDC ( )Tj EMC 1.03 0 Td [(\213\022\026\021\036\030\017\027\002\031\030\020\026 )0.6(10.04.2023 )0.5(\020. )0.6(\f)]TJ /Span<>> BDC ( )Tj EMC 13.224 0 Td [(\032\026\035\024\002\026\n\017 )0.6(\027\026)]TJ /Span<>> BDC ( )Tj EMC 5.857 0 Td (\002\024\035\017 )Tj 0.524 Tw -20.111 -1.218 Td (\r)Tj /Span<>> BDC ( )Tj EMC (\035\036\r\024\005 \023\024\007\r\007\024\001\027\024\005 \024\002\035\026\ \f\021\017, \035\024\032\027\t\036 \023\024\t\r\t )Tj 0 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC (\007\036\235\036\022\026\006\017\033.)Tj -0.057 Tw T* (\207\024\035\036\036\021 \r)Tj /Span<>> BDC ( )Tj EMC (\021\036\004\036\027\017\036 2 \035\036\021, \022\024\020\007\026 \f\021\ \026\035 \024\021\n\036\004\026\021\034 \023\024\016\r\035\036\027\017\036\ )Tj 0.159 Tw T* (\023\036\030\017\024\007\017\004\036\f\022\017\b \f\023\026\f\021\017\004\ \036\f\022\017\b \002\024\035\036\005 \r)Tj /Span<>> BDC ( )Tj EMC (\020\017\023\024\020\026\f\021\030\026\035\034)Tj 0 Tw (-)Tj -0.039 Tw T* (\027\024\005 \024\002\035\026\f\021\017 \032\017\r\024\021\026 \f)Tj /Span<>> BDC ( )Tj EMC (\017\030\030\026\007\017\026\006\017\036\005 \r)Tj /Span<>> BDC ( )Tj EMC (\023\030\026\r\031\033 \027\024\020\031, \021\026\022 )Tj -0.079 Tw T* (\032\036 \023\024\016\r\017\035\017\f\034 \035\024\032\027\t\036 \023\024\ \t\r\t \027\026)Tj /Span<>> BDC ( )Tj EMC (\007\036\235\036\022\026\006\017\033. \240\026\035\024\002\t )Tj 0.085 Tw T* (\023\026\006\017\036\027\021 \f\r\016\t\r\026\035 \f)Tj /Span<>> BDC ( )Tj EMC (\023\f\017\b\017\004\036\f\022\017\n \023\036\030\036\027\026\023\030\016\ \032\036\027\017\036\n. )Tj 0.034 Tw T* (\221\017\n\023\021\024\n\t \022\031\023\017\030\024\r\026\035\017\f\034 \ \002\036 \023\030\024\r\036\007\036\027\017\016 \n\036\007\017\022\026\n\ \036\027)Tj 0 Tw (-)Tj 0.231 Tw T* (\021\024\027\024\020\024 \035\036\004\036\027\017\016, \030\036\006\017\ \007\017\r\017\030\024\r\026\035\017 \022\026\032\007\t\036 3\2264)Tj /Span<>> BDC ( )Tj EMC (\n\036)Tj 0 Tw (-)Tj 0.668 Tw T* (\f\016\006\026. \200\t\030\026\032\036\027\027\024\f\021\034 \f\017\n\023\ \021\024\n\026\021\017\022\017 \031\n\036\027\034\001\026\035\026\f\034 \ )Tj 0.112 Tw T* (\023\030\017)Tj /Span<>> BDC ( )Tj EMC (\f\024\002\035\033\007\036\027\017\017 \007\017\036\021\t: \031\023\024\021\ \030\036\002\035\036\027\017\016 \030\026\f\021\017\021\036\035\034\027\024\ \005 )Tj 0.187 Tw T* (\022\035\036\021\004\026\021\022\017, \022\030\031\023, \n\016\f\027\t\b\ \002\031\035\034\024\027\024\r, \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\017\f\022\035\033\004\036\027\017\017 )Tj 0.146 Tw T* (\n\016\f\026 \017)Tj /Span<>> BDC ( )Tj EMC (\030\026\006\017\024\027\026. \200)Tj /Span<>> BDC ( )Tj EMC (\026\r\020\031\f\021\036 2022)Tj /Span<>> BDC ( )Tj EMC (\020\024\007\026 \023\030\017 \022\024\n\023\034\033)Tj 0 Tw (-)Tj 0.194 Tw T* (\021\036\030\027\024\005 \021\024\n\024\020\030\026\235\017\017 \024\030\ \020\026\027\024\r \002\030\033\001\027\024\005 \023\024\035\024\f\021\017\ \002\t\035 )Tj 0.122 Tw T* [(\026\023\024\007\024\030\036\027 )0.6(\017\027\235\017\035\034\021\030\026\021\017\r\027\t\005 )0.6(\023\030\024\006\036\f\f )0.5(\f\017\020\n\024\r\017\007\027\024\005 )]TJ 0.402 Tw T* (\022\017\001\022\017. \230\024\020\007\026 \032\036 \002\t\035\026 \r\t\023\ \024\035\027\036\027\026 \022\024\035\024\027\024\f\022\024\023\017\016,\ )Tj 0.066 Tw T* (\023\024)Tj /Span<>> BDC ( )Tj EMC (\007\026\027\027\t\n \022\024\021\024\030\024\005 \024\023\031\b\024\035\ \034 \021\024\035\f\021\024\005 \022\017\001\022\017 \002\t\035\026 \017\ \f)Tj 0 Tw (-)Tj T* (\022\035\033\004\036\027\026. \200)Tj /Span<>> BDC ( )Tj EMC (\007\036\022\026\002\030\036 2022)Tj /Span<>> BDC ( )Tj EMC (\020. \023\030\024\r\036\007\036\027\026 \022\024\n\023\034\033\021\036\030\ \027\026\016 )Tj 0.084 Tw T* (\021\024\n\024\020\030\026\235\017\016 \024\030\020\026\027\024\r \002\030\ \033\001\027\024\005 \023\024\035\024\f\021\017 \f)Tj /Span<>> BDC ( )Tj EMC (\r\027\031\021\030\017\r\036\027)Tj 0 Tw (-)Tj 0.155 Tw T* (\027\t\n \002\024\035\033\f\027\t\n \022\024\027\021\030\026\f\021\017\030\ \024\r\026\027\017\036\n. \215\024)Tj /Span<>> BDC ( )Tj EMC (\030\036\031\035\034\021\026\021\026\n )Tj -0.028 Tw T* (\017\f\f\035\036\007\024\r\026\027\017\016 \002\t\035\026 \026\023\024\007\ \024\030\036\027\026 \024\f\035\024\032\027\036\027\027\026\016 \235\024\ \030\n\026 )Tj 0.057 Tw T* (\007\017\r\036\030\021\017\022\031\035\016\030\027\024\005 \002\024\035\036\ \027\017 \021\024\035\f\021\024\005 \022\017\001\022\017 \f)Tj /Span<>> BDC ( )Tj EMC (\b\030\024\027\017\004\036)Tj 0 Tw (-)Tj 0.068 Tw T* (\f\022\017\n \007\017\r\036\030\021\017\022\031\035\017\021\024\n \027\026\ )Tj /Span<>> BDC ( )Tj EMC (\031\030\024\r\027\036 \f\017\020\n\024\r\017\007\027\024\005 \022\017\001\ \022\017 )Tj 0.368 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC 1.118 0 Td [(\235\024\030\n\017\030\024\r\026\027\017\036\n )0.6(\021\024\035\f\021\024-\021\024\035\f\021\024\022\017\001\036\004\027\024\ \020\024 )0.6(\f\r\017\013\026. )]TJ 0.057 Tw -1.118 -1.218 Td (\200)Tj /Span<>> BDC ( )Tj EMC (\f\r\016\017 \f)Tj /Span<>> BDC ( )Tj EMC (\220\021\017\n \r)Tj /Span<>> BDC ( )Tj EMC (\n\026\030\021\036 2023 \020. \023\026\006\017\036\027\021 \002\t\035 \020\ \024\f\023\017\021\026)Tj 0 Tw (-)Tj 0.303 Tw T* (\035\017\017\030\024\r\026\027 \r)Tj /Span<>> BDC ( )Tj EMC (\024\021\007\036\035\036\027\017\036 \026\002\007\024\n\017\027\026\035\034\ \027\024\005 \024\027\022\024\035\024\020\017\017 )Tj 0.026 Tw 23.244 60.89 Td (\017)Tj /Span<>> BDC ( )Tj EMC (\022\024\035\024\023\030\024\022\021\024\035\024\020\017\017 \206\202\211\ \003 \221\210 \253\221\210\025\207 \2251\273 \007\035\016 \023\035\026\027\ \024\r\024)Tj 0 Tw (-)Tj 0 -1.218 TD (\020\024 \024\023\036\030\026\021\017\r\027\024\020\024 \035\036\004\036\ \027\017\016.)Tj 0.028 Tw 0 -1.218 TD (\200 \024\021\007\036\035\036\027\017\017 \023\026\006\017\036\027\021 \r\ \027\024\r\034 \024\002\f\035\036\007\024\r\026\027 \r)Tj /Span<>> BDC ( )Tj EMC (\f\r\016\017 \f)Tj /Span<>> BDC ( )Tj EMC (\027\036)Tj 0 Tw (-)Tj 0.213 Tw 0 -1.218 TD (\f\024\024\021\r\036\021\f\021\r\017\036\n \022\035\017\027\017\004\036\f\ \022\024\005 \022\026\030\021\017\027\t \017)Tj /Span<>> BDC ( )Tj EMC (\030\036\027\021\020\036\027\024\035\024)Tj 0 Tw (-)Tj 0.297 Tw 0 -1.218 TD (\020\017\004\036\f\022\017\b \027\026\b\024\007\024\022. \215\030\017)Tj /Span<>> BDC ( )Tj EMC (\022\024\n\023\034\033\021\036\030\027\024\005 \021\024\n\024\020\030\026\ \235\017\017 )Tj 0.188 Tw T* (\024\030\020\026\027\024\r \002\030\033\001\027\024\005 \023\024\035\024\ \f\021\017 \f)Tj /Span<>> BDC ( )Tj EMC (\023\027\036\r\n\024\022\024\035\024\027\024\020\030\026\235\017\036\005\ )Tj 0.181 Tw T* (\002\t\035\026 \026\023\024\007\024\030\036\027\026 \026\027\024\n\026\ \035\017\016 \030\026\r\017\021\017\016 \f\017\020\n\024\r\017\007\027\024\ \005 )Tj 0.248 Tw T* (\022\017\001\022\017)Tj /Span<>> BDC ( )Tj EMC 3.108 0 Td [(\227 )0.5(\r\t\016\r\035\036\027\024 )0.6(\f\035\036\023\024 )0.5(\026\022\026\027\004\017\r\026\033\013\036\036\f\016 )0.6(\031\007\r\024)]TJ 0 Tw (-)Tj 0.129 Tw -3.108 -1.218 Td (\036\027\017\036 \f\017\020\n\024\r\017\007\027\024\005 \022\017\001\022\ \017 \023\030\024\021\016\032\036\027\027\024\f\021\034\033 \007\024)Tj /Span<>> BDC ( )Tj EMC (15 \f\n )Tj 0.275 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\027\036\030\026\r\027\024\n\036\030\027\t\n \031\021\024\035\013\036\027\ \017\036\n \f\021\036\027\024\022 \007\024)Tj /Span<>> BDC ( )Tj EMC (7\22614)Tj /Span<>> BDC ( )Tj EMC (\n\n )Tj 0.037 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\021\016\032\036\027\017\017 5,9 \f\n \017)Tj /Span<>> BDC ( )Tj EMC (\006\017\030\022\031\035\016\030\027\t\n \f\031\032\036\027\017\036\n \023\ \030\024)Tj 0 Tw (-)Tj 0.126 Tw T* (\f\r\036\021\026 \007\024)Tj /Span<>> BDC ( )Tj EMC (11 \n\n \(\217\017\f. 1\). \215\024\b\024\032\017\036 \007\026\027\027\t\ \036 \002\t\035\017 \023\024)Tj 0 Tw (-)Tj 0.246 Tw T* (\035\031\004\036\027\t \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\017 \023\030\024\r\036\007\036\027\017\017 \017\030\030\017\020\ \024\f\022\024\023\017\017: \027\026)Tj /Span<>> BDC ( )Tj EMC (\235\024\027\036 )Tj 0.167 Tw T* (\n\036\035\022\017\b \027\036\024\f\035\024\032\036\027\027\t\b \007\017\ \r\036\030\021\017\022\031\035\024\r \035\036\r\t\b \024\021\007\036\035\ \024\r )Tj 0.109 Tw T* (\021\024\035\f\021\024\005 \022\017\001\022\017 \024\023\030\036\007\036\ \035\016\036\021\f\016 \031\007\r\024\036\027\017\036 \f\017\020\n\024\r\ \017\007\027\024\005 )Tj 0.23 Tw T* (\022\017\001\022\017 \r)Tj /Span<>> BDC ( )Tj EMC (\f\030\036\007\027\036\005 \021\030\036\021\017, \023\030\024\021\016\032\ \036\027\027\024\f\021\034\033 \007\024)Tj /Span<>> BDC ( )Tj EMC (15 \f\n )Tj 0.204 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\030\026\f\001\017\030\036\027\017\036\n \f\035\036\023\024\026\022\026\ \027\004\017\r\026\033\013\036\020\024\f\016 \024\021\007\036\035\026 \031\ \007)Tj 0 Tw (-)Tj T* (\r\024\036\027\027\024\020\024 \f\036\020\n\036\027\021\026 \(\217\017\f\ .)Tj /Span<>> BDC ( )Tj EMC (2, 3\).)Tj 0.358 Tw T* (\230\026\022\017\n \024\002\030\026\024\n, \007\026\027\027\t\036 \023\024\ \r\021\024\030\027\024\020\024 \024\002\f\035\036\007\024\r\026\027\017\016\ )Tj 0.354 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC 1.06 0 Td [(\002\024\035\034\001\036\005 )0.5(\f\021\036\023\036\027\017 )0.5(\f\r\017\007\036\021\036\035\034\f\021\r\024\r\026\035\017 )0.6(\024)]TJ /Span<>> BDC ( )Tj EMC 17.577 0 Td (\027\026\035\017\004\017\017 )Tj 0.274 Tw -18.637 -1.218 Td (\031\007\r\024\036\027\017\016 \f\017\020\n\024\r\017\007\027\024\005 \022\ \017\001\022\017, \027\036\032\036\035\017 \020\017\020\026\027\021\f\022\ \024\020\024 )Tj 0.238 Tw T* [(\007\017\r\036\030\021\017\022\031\035\026 \022\026\022 \024\f\035\024\032\ \027\036\027\017\016 )0.5(\007\017\r\036\030\021\017\022\031\035\016\030\027\024\005 )0.5(\002\024)]TJ 0 Tw (-)Tj -0.017 Tw T* (\035\036\027\017. \200)Tj /Span<>> BDC ( )Tj EMC (\023\035\026\027\024\r\024\n \023\024\030\016\007\022\036 \023\026\006\017\ \036\027\021 \002\t\035 \024\023\036\030\017\030\024\r\026\027. )Tj 0.17 Tw T* (\215\030\017)Tj /Span<>> BDC ( )Tj EMC (\035\026\023\026\030\024\f\022\024\023\017\004\036\f\022\024\005 \030\036\ \r\017\017\017 \023\030\017\027\026\022\024\r \024\f\035\024\032)Tj 0 Tw (-)Tj 0.14 Tw T* [(\027\036\027\027\024\020\024 \021\036\004\036\027\017\016 \007\017\r\036\ \030\021\017\022\031\035\016\030\027\024\005 )0.5(\002\024\035\036\027\017 \024\002\024\007\024\004)]TJ 0 Tw (-)Tj 0.093 Tw T* (\027\024\005 \022\017\001\022\017 \021\026\022\032\036 \r\t\016\r\035\036\ \027\024 \027\036 \002\t\035\024. \200)Tj /Span<>> BDC ( )Tj EMC (\n\036\024\020\026\f\021\030\017\017, )Tj ET q 274.961 111.796 221.102 254.705 re W n q /GS0 gs 221.1023475 0 0 254.7118274 274.9606228 111.7900735 cm /Im0 Do Q Q BT 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 0.094 Tw 9 0 0 9 274.9606 100.9959 Tm (\022\t\217\210\b\002\220 1.)Tj 0 0 0 1 k /GS1 gs /T1_1 1 Tf ( \222\220 \n\032\202\026\021\n\027 \005\032\007\001\021\n\017 \033\n\023\ \n\t\024\025: \t\023\031\033\n \016\026\013\026\021\006\025)Tj 0 Tw (-)Tj 0 -1.2 TD (\027\026\007\211\031\031\t\002 \205\030\027\n\031\021\025\031)Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf T* [(F)-16(igure 1)47.1(.)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf [( CT of abdominal org)12.2(ans: blindly ending doubling)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\037\035\030\213\030\003\t\021\037\030\t \213\b\214\035\200)15(\255\t\213\030\027)]TJ 54.711 0 Td [(C)10(A)20(SE REPORT)]TJ /T1_5 1 Tf 25 0 0 25 505.5395 56.0378 Tm (137)Tj ET endstream endobj 969 0 obj <>stream Adobed     '$''''$25552;;;;;;;;;;   ####''',,,   ####''',,,   ####''',,,""  !1A"Qaq2#B3CRSb $%&'()*456789:DEFGHIJTUVWXYZcdefghijrstuvwxyz!1AQ"aq2BRSr# $%&'()*3456789:CDEFGHIJTUVWXYZbcdefghijstuvwxyz?I&D)5iiYY`[mA=mpJML .RWMs*m\r(lZ⃟JQ]4J4m~K؋WZ U.\ 8q4\r*P2TIH9׊˗)FG4inCW+xYj+8*sA'E*TڬH7:8ӻWSKM&ߗb5C9dvi\ܖz5ĸdžAC #&h єܜC\ YfoL|ZW&UƲx<^nuۻ5ѱR5[683VY)%B=BU[ AޥJCKWݗmDuO}}7nUhjFMnzWڳj-}}圖N*|+ B\"h!V[HT̙`"wu ;KI G/ܵO۠JМ^}uM[g|_WY\JyIW<7z]-:,K:4"\J(#ty CYVJ=?'KeĐsڟZ:}8Է;qZ@U-4׿I|Zqwz%`8Uä{nA*,3UN?S<h6Ɲ~1h3\_//3{B+ҷ_ifڶ5-. 9wk;4M+a@'Ы#3{T3a!xqp( qXhxv-lWRW8_wwfxoh͗LbԻoMO)Mv:m*Bl:2Cknjۉ-J4&kI p'u:j[#n5Ժް`C烻O:w}bs^;㾟=-{ېܹQQ'iR@wQ$WE+J5}}m-k_in}ݗ6nH_C~_h{Pni=?пut1wѧ#nǂ@#UG)#MԩX 6x7u}K=ն-Fq?*m_fk4бn–;V]cinX৳,۲0*v36q5ҽɵ(VO_|-qs~x11޾w-Cjmbj5}c+GOдOJnլK0ENĤRr/Nb4-.[=[cG[fh|;8&% uNKE5D6R|x]OwZ[-kܷX,}qY5;z:W9s*.kiv1Ս J c>G×jin;DWeRC 1,ti_n뭺p{QV#cQa*|.,\׌!_᧬SU*W߅W١~+jx-[ۭm."+~ >-o Z\.="+^mYeڄItekv H1]&u3XfԷA}%y*>4'q G$d k 5ϛ|nj_~n̗vFVJbh{k{޶7,\T2fR7V$8iJe*WAe.д^[eΛ|t~ncRK58JW!mUbJ&UrozݦZjۭV޴rPօZwC˗% T/ZGI|'Hrh]%܊c0\LTۙr˂*AmN֙ɚ۸Spm٢`@TY.6 2X=O u,^9Z}|OImo8+#is}.{\,9G5e=ò# 1'm)- 'J_k{_i]\ᅗ&v$3%#/yS}S:zPի`tU G@F &*P}oԷc1|}ך9V1WmmlY/WP%BWTF6\1YCdo@!r}IR_Ck~w{-v/xgm[I"CaE=^OH8?vR]. Ob+{~"t'SjjxSjEMv6wև{t"KDV])֮k{ds|BbU*RX0xee{嶖tzUǭCN5E /+(Er&wOb+࿏mΞӰv5궶c-*B鼶<^vz?E|glYeڜNJ7xgZaI7x 9TWp5\lܭlw+.R .%֞%a˶\J&4N#%Gp\\@9qJ0GNi 7Z ~5z'Wt2YHx0sL^v<.H1#ErTg־ 5 ]Qcp+[ۍgӉM| [_MKۛ2r#R`H3jT]$%ZXBEzTw>]v`18|ex v[mq^FE$XԻNfh#fB !Q0V*Ex^훅,tA߁ھѽԷR2˓߁>7IR :W٠\] pשCkMǹ ٚ ]"wNm/wvbJ@",-~P-}_f xOumFَ/^st-1RHA;J2L%G 4/fѲ7`|DŽvC}߻Эii[mA֟ v0Ry{Um{T@oЕZߥ]Lp?IY'N,7nSs,/ oꗴm_u}7v;c| H\nj4jHU+۫a}{߇)4|>6[8萸ѭ% )R{NmˌGzKY4Ow*y}4[eZ݄qJHԩUybLw˺qsIfZDuF ti5oS,6ͬ:Kb])R4LBqF/c{Cny/ztr#mR-kbYg^?y[..fJWQ(qvJSx:UL3rO_l ?j~ SVW[ɈJ˶@t1 73RP8j#ı,o@i䚥)C5Rt۬ms;Gk:ڹS$ԭ*BMV oҏwӶ\]*of7CWk!VoucCx{lӾ5 -<$.'*nHgfiIܮMRYoӶqVzxڧZԴWR)Bj"]4ӄvW.\w)Rwu5Fk~3Jۜ, J(Mf*2"$툢kA;BzKBKl?e0Ҵv]lڳWQqM/eLZ'7£u ?cuI&%<:j; :χbF:)Jfץ6{*[n'=3Y5ھV}0qj+khC;jQ1ӹTJ%^۩u:t]m} wsٴko.>^쫛6plIVAJ5NNە#=덛#M7Z\I*MK3]5ӌs^E$8gHt#_Qԡ_~YSSC,R{{ᴼV-1? |v=mRpX[$Ew>vi 6L:tHrkͱ~|mlt>\inxOsBPҧ;[?ڪ>H%W~k8W | sʯ-|r{Gvj3v UBM\/^e zmgab[iY\Si:ZNUޒ[M[rspJVM[twk$MinP'H.V%~& u*]-ouTƴ# R_Bs_+~?_|<4t=}mzLFRkj_RϫR"療n-n$~5͞: oKn&TSp3/b +p,i{ -!0Hu(5C7]lit5FgWk>'B'?ٯ%ͳx7fmJ`I\\r7:,*2g=aZJ;ԻHp?)nZ]y556=c.uS֪b Ds9~(2ֻ [x0bumzns{?GhY}-% ~ݺIq>^L%;LJI:$R|fix]?,ӴjOF.o}mr˔R)‹0U#=Mf? 2e ]p}g:-KK+|]ڷݩs闥Z|t mu=lvP+ޯ4%sތ;^S7 >+32`m=U]2.&,{ {gnh=cҾ~e˜Z彥ྏҸm-K>pzց>Ibe5#db#.kN 5ۭ}_3~_Vwtf;5S7==4t]_wtUѽ7XVF1G#Hn ]<A i9f\>[9TG3_ž#KXWJգK"@3C1(ӝdMR}`2u|Zm mٷImZ\f)R.JJ.3ئѶPۗj\>/S`54;С,8ڰƆkPZumLv<fs/o*Xպ=ե=ms𯇫[en3ǔd`9iOX0lDXp(B{˽棝 ֒/|NW{"[nat[z6 :S$0ra ~.8_MTY#, *SjxZŴcC? Ὅ=뭺tὋvYuƞ /zaeV*%βpngV=g*Mwt{G,^ٴ9'{mn BBbш {mN>\dx0`-GX[ֻ$Q8lqwTwܥFFveZ׺q~\[N+#[}K- MWѾl󍱷tI"|ڎtY*:f3UW=nvw]g^n-=|`AGҖ%"h:\E#mEv)jՉ={U\T~&MG"'U:yM„5nvU,a+@|sn?5rVKKIdm n*m.g^u}Ҡ}m۫co"D~FiӪEj1T_nF3޴]HbK "ڬԛ3+[тCM\ |k[o544J-[>խڑr(Rl]zH1\RritĴӈ:ة4BHit:/)1+|jT en[n1U>2] mp`D0G#z9lΌh ۨV0;*P;|/Cm]ڰ1%H +vgiJپ4t9%C=Fi.-[(R.\J`@QRrTRJ $\-iٵ,iv)֎2v*Tk'f]nWsy2g^qnmXuu,2uy&a崋K\=.V+!ru0Dfh)^-` 9*7=5RYoԲbHKu٦yqV[#u>uK[>ֻنC6q$]lCsygfIÈhIF=_f%wjJ!H45|>< *ۨ\['={CWۢ{ ,yԂ7hh?ZʷUd涟*WCiNVj[_۞&-=;5mײֶus˙r7ZGۭ`Bwife*j.w!jiJ5Gy}BQQy)e> WEN*6<ǥ|~53­_m[r]c+'J>c/?4:+(V]ZyU:V8qCQmL$Q~˗)BG"w*%C^gBr[(z#xZݦVR##b`R.\JbNx8cJ˗)R:ъ^8=iW.\Jh@Bdh ӓ3q2G])E\SSX]ku^fkJѴvq=ʴL~Z[R+? 0E9J]ԈM-r5mk3=t>#叇M<)ΆVB>0񱠖agB {RW_ uuz}u[Nc/׎TonwwW[jڏf:s8b^6'nH뺔kܾs%Uuڗۣ5~ ]7OxfGW]iengE˩**=joVQHJ5'RBGRx, |r-/}xS~ ay6]ھߵ=Oշغa<ۂk{$ mʻyr3? lEi٦K|+V%V*|or{ܮ}ړ޾k#Skھ܋ZLg5+x/~ ՅʿԞ+vSW Jۺ>@Յʿܞ)|vSEJI}/X\̭:_ϭnOz|or{ܩM~m{W@_H41w?-߯F-G,RtD yOύnOz|_r5ש_^?=w=ދ?Wx?%SsIw_V3b'}>7ݹ=T&?y6g3Eҷ ۥ1T¾G} гۖ|2 !Y{+qIg( ~wj]6Ϳ(nѹ7K?r uJ?KG,Z7\c87\{'RNJk/K-PZ+cz^k٩\Yt8LKI{zo?/WkYum ھ,>788\eىne0`2+K~8}*۴,ԻNؿUm h\߶? 'Ӹ־ů! Fa15tm40E7< u5ge ]uK}[4qsi| vY[nGK)pOhb.AV} ~vBg+|᧏}jXWu>ۦ_tZj,\_rσݹ=5ש] dc>??ԥ[W}ۓ޾wԞ(}_z^niQG^_D -fnU>7ݹ=Wy_r5ש_[~4b;#_!d|~_<W}ۓ޾wܞ*}_z^mx3_ >?$i|~[$ܞ+vS3 Ҭ[|_әR #[cBM[ܞ*M¼! U#=w~Sm^"VoԺRmcסX/t%~x{/` x!f&JAG;uC48cρՖ7*}~~{~j- L^*6]ywoFE(&#hmwE݊uF=bh~nZ>?qyv_V4laW{/kx3_Sj"B+V"c,oE0F'RqnOz>ש^ix}Bs?:VZZe%hosru&J/xȘƑSϣݩ=QI2-Ozn_m:nΕˈBY5`>5v<tXGG¥\}ۓ޾wܞ(}[z^To[^ ozr'}_> 'WDz?yKW}dC|/_X|G5k6l3[ǭhV뭫~AUG@Ѹ[ukW[3Dz1Twvq_~m.ԃswىnhǴ/3[Vo'QkuLcNeisO ޛ*q) t:)$P-owjkm*4zmMB!]Y/ܩ3r-EObj_UFyu[w1{C_X}L_qv\۪۶&GZLbf>23!|II$5x;<l.f+=ijtnֿku[hN'1_j)tm, -8:եH$U 헫NȔő5v}PRxnjuwf4 KxksSORl4U֭Asp`^^uuVxAsn3U ^Zo5j#g/Z6l<\]TOO: I,N0溶Z_f~]mG/u[wi٫ogw5ԑJ5}ɄyIlrKY$c KDksM8)%Ruӷ}JݷSJi_}=f[X  'kӚ`!CjjPsmW~k_}^-ӲNLzW[m6'Zuq~UF_Cm- 椗$J3~?kx{uAWJqJoY@n1~˾]|/C_ULZfrRJ4,-pbE.Z˒歹*.1PG'uWZ>[K\OkP&|ъ䋒JTG40pސzEֹr*G0EN+ZQPGgEk. @Rϥ.yzT/-=bEatSBZEѲ"IѝZ(5-l]m&0מ{KxM+lԳgש:6+ 6!on]k/N^7H5ݤ_tsKcQi= 1 j+ԶŎ.Mu c#uWmŚ=n2M/,ȻraW7EhawϽhƙ~ g׷{x 8t-?~W۪7Y7<&-4m?9$a(ԾnN+?x};Os4_3~7]&ͻ5u|bYcTk.R}xjW'n F1:\K6TKsՉb_M+Vqofw45˘ֳmQBWNJ/,]:=ca6Mr4P*]uyVj]5!/ R}O5Hs.<PHo@9(5܍ ;[H֋r4ش4,v]VNӧ%oQ=S[ٞ4^oVe[knױZo\U)tl:m"=sMNkƩpk}QUx]]}]+e8hվ,n+W_=f\/B;m!=HbeUZ: WgG ^o{7^ÑR %|OhZ]f_SXݩ0&8+߶jh>Tw/T' I>'گ&&8'Tb #/ԡ\y{xOM.:[A`wW[j\\Sޅq 5y&Z.'Toߪc)/R]ommm/-u'ﭾۂZXÊl3ž_y{,'Ԧ.Rub+RRt!O-%z )F/n-n7V٬Xmmfx֬糬x鹺 c \.)IҔPPn?뭟sb\LzPкۗ|J@]kJd#mPLr.㺕(1\ꫯRCD>uZ%kK R"+ W[EBsUlKKUo/5^׿WGRt9jk*xSczSf60@[a. f͢=P00hJ[u!۞$yv׷7+\/6_?&jZ sޔlStPŷh몹N=Rc8noj?G"kr?Re(y&#_-lMu+V"Hnf&8ޥHem8nAK6Ғ(h"GŌ.:Vou<3[{掖XVhx}0mOm;/nԛ'Wq8xҠk:5jQ7o؞"k<^ƝɩFbvpA=yX~K/oJmv˗o*;-xkxCښbhA]p,?*.(tymSD)Rh x#ݮ:w7  c4[m'Rzg"wKJ_!Id‹F)A7C>9gdЌa ` )B]{xtN>h2׻Ke'GuFfy-bO 7G紵ŧp:CCr@ԡC\J^47Vˋݪ$~"bf*+|woo5 'Gښz^-Z)+4)-uRuTpg#i`洖a>e ˢՑ8,BF:=H3??(+8mγ^-э7!J%Wo /hhm![ Km+meJЏBO؞&Om2~jnMf$6I Z8YBJEt-Kgiz:vݛZe{kGݝ si~~UW%%J^XJR/jB)g<H{Fgɠాwo4_RFz?jYm^m5+ZGѿZ4w-NUlqv$ -p%L[B|Q@ĜMvL ު.mqPyzQ A:mXǴv J纉4QVLJMj\ ju3J ?iLGS[32>Sq"6OTI mX`Y}:s_hmo q]%C~{.6k$uiY~t]!$ҘxWc;sf}V/^JTڎ.[o*ˮ[-"m1]7ںӺp'xdh7khB/ Ew70ݒEl4;1%TF\)#4_lՍݛ׿SݺvKt=}ax?v}#& I+@]AoT9 +R}Og +FNsx/---]?ۂIL ݩn"r.iۙY7b\&]AUͣѴ8\F 7N>=w5K}Z9ZОٮKuETk&N) m9ic s^-ZTP۴# yI-Iu;&qݜwZ#1V5P{Vz+|:WE8m\E(5+׊~xiۭk}rW7 k5:~7]6N%w裒F9f.S (J)F)8(Wijm7=_TzH7$YpM5zݜn& dg׷˕CKAB m6j?G"kx~4F ?)ڽ+'źVӾ'dӺ-yCqic$g^<Ώ=n(ZRwY8-^nUZ#KB慎ΚԶw~jV 5ܥJĺbݚ7ešlA*{U'x-w]k  o$M$Rm>f8j7Z1 gҹ*HTGuIu(*m~'Tx-GR.>5$\Ju{j+*[ilyQn./5w ^ΊTnK)}'3L2vD!ZWWfL ޏ?#vnMpFZ=]ޥHn 7ejj:m%Cj]au헉NL[jLw=R>5<m)FH>5]&Փ;]tJdCk-օ>ceł@ZHZ+0iGɇkQOo_&ju4tԿ.c4m0REJu-[yd! _"4ne:ʟ 0\34yi~Oƨ lfD*W?E1gdLq*j,(_rמ&۪&t}!Qj=,ևFHbH ྋӋIjw[\$һ![}Էz_/\W uq*6 u^y!ha a5|J$aOVI,F uez_GMo,nݷ+ώ~7]iځ,c۩tIi[AvvĚʂFqui)@ب-:ڭ^f[.ж1bŸ5 zúL}-=M;5ĺGYu ep:RsdZJ PMD~ˇj_ZnkVQ [@SJ4|a/z~G#[}ekͦlL鱞Ke$ W]i!)mW>&5-LOՖ6-GXxI,uTW~D{R˾zjTԸYư3ž"ӷd^1]#l4- ʺJAд=kR u\9:i]Kl\UWjc%Zv-mG1;B9tnvh)WoO+R5OXѴv62}{'^ZjZhh?ߣjlF/Y&+ARyr_NB3N{1 Ma0 j)Rkյ<6cSM5x +wh9cu2=kO}[u,J'\P;I)Бto zRB[Rzhݩ|Y8Z⽝mU92sWxOwӻW'o.A>dnH^sE$nԩZ4|-[mPն6p[jvK*0qg7jOQ'=iP?Sų͖Y]7k_n֪˔3nJU{Q{Cxu-~-t1F 3Y#D6&nJg}|Uv}֝eG_Kڞ0>[YaNF_nїs ۗ/EKtr`^00ukV0q(N-]]k"=Bj}&V{Nڷ}kem}+"3֣h=4.. F'SR)û~Զ xS'PgԥغF,~lKyMg?oJ'4F#ogeڷN\WZ k3 j5JYV..Y3Aq]ͫ8\AҬi}xsnݍ. b:7^ [PlɸF7SYtִenIxgw{=Htl_Ew^/_<)O[ۚ#uZZn~Y'iI_?)w_^6Ժȷ@<],qګ5CT XdkNĽNܭ'@J#{?Dz/[w_'hэk|i糞1TcKnvܓ#T{ 5wiyN/s\t+9~(mR/6ohS;ix_ v6LWqu؝U\EҴtgSoSO+ wjhRovwv߱vYais^~O_vv--0G޾km6?qM;]K[4&-f)N@ךm}iR. TCl*qrMBܽWmq4˷NhJTmnRmnkk:W\D]{,;TSd2e)AD ལo$_xm,v_xs>.S]~ oԶnbaG5s4g@:z"\k5DGp4sk&Ὃ|_ltۻ1Y_kxKMsI[q^W;l/[T׌YC\hm+an5{j#BZtɼ9RYu_7kz,No@|oWjixv+u bx^dz[pֿnʮ4x2(Mg =V8) ޯނ#e7=WϐB\៊x ۨ߹m7ZI'QyCk65un,-'W+ }ta,!͘&Gf]e`ѕaܬX"kpjWa?Uxv݇G8bZ_mLmr]mdR]uW5Q׻ʾ?@^llP(1!iƕm ~N߳aϫ_[sZiݩsveu['+6&۳?.~ :3+; SI)8L+ *>4)^6g7rcV ͳZcp[Z[}";Wٿq]=>UTc`j̘w3@J4mORԽ@Vag'z|p*DIoj/n]qn*Q;u4.>-'5RYmmݚ_Bb$&8LKV!V`h{ Zޥ ,#-ז\ĕ=-[7r+ 2u~ӻ-,b!'MUϐ łFAX(V{;T5:+ۻVlni[x}ESNۋp=+^^ ]][neHsdFY27I]#v)$u@ eE(U#R湸AsInncUpG\Qu-ۭu~T=6쫎sթ+a >mu*Rˈm NTϼlm__~̻ھ[ sC4}6UZws\ss)ٵ)~]{9$EtZwjji;NɘD}+|jQ.[+_6mEh͖)[\}Fۧߢé_};m ;K@-V0ܚ GE XD6},xͼQ:_Z8SmڗNfW&;:}#b `sʉطkJ\d-h6Ӣx7d(Uܖ$h[o-!o/n"Y8wOcel/nGe$a:>F7К+E䣯5*U yvSkO(FuZmwM4WRkZX+5;1ݭTzf߭zFڳiwn#ױx/ ѷFۼ|ו~ +gtt۞.ko8Z,+QVZwDM>=U]wK^4u㤝гں~ˮu%44ZJ'ZƿIikO"ڔ)=gږ[sziܙ7?iOŭx[fKU^D԰f%34>GA]-;ln^z'< +#/ v8#0B=*ۢ3cCY}魩f,6˖>t;?KSSR-BIwqkGR5 X<6\ T\;끠آ8l8{\<`aޭeXHk}rJ^{PՊONbrC䟂f|.y~ۻ({F˦re"iˈxO0۞LYe@i7o-s7n is>= -yrP&8ת6TwehEi=g4m/;br̓n45 E։o=ӾK zs hsQ `uoge 6Mdj)AKDԸr^og߯E&q\u֖D,4d.3 oM-aˎjPmݼNΉ4z2W?Q#%Uc䘶ܫۚbbճQ.8V+G+K[: ?XICM\6(n|rr]0H@6XvZV)Neo_-={0lJd/:.W}e`)8:1)͘SR $fZ+_>;SP-40*I;'ϥiכ+V!"8[CTL0Ykւԃda:YmoJ>}+ us$*EJ۸KOÙ{]E4Jp+%:V;1%HJ{[dsS&Lt*&ݤ\`us𨟕tjbpϑѵ~0)0OSFM[&mƴ}]JFQKm"+#.=ɷZ{ԣI5=ӧ&{J fnI*k]7ţៅc>ooF">$~wOD'TNkm*PV|_ {_*q"W+~SFk`{7Za]e5#qѮtonh'nͻ) GDjZȩROf0~[5}b1G{Sk%]n?|/iͷ3}i^i16֒1 ~O'mUe-0Gl<&ݦw`Kg5n>vjYmmWck r]3 Tc29fb/G8 jWԿu70zo- -zG5}/ijj\Yf^3R}eNE.9ZKΣ]#|qY.q4JWiAl)mmVibCѡS5[ I ު7k>zS~{2m-mq?K,z{--mRӹz@'Q姑)qav|C_잪ۼ_ձ ֎8+Onj/ӾQLo omW5+NZ:uG ۮi̐*W_7#Z5Y99x;jk蚖Y6;ٖx0/9i#{l+=IEj A@]a]srkKRV{K7I۾7u  =ὟW~dO=?vunJۙxKڞֻڷjjk^cTBlN2C YH7I]r.\v*WɕJPa3JF]}4m|Fkz෰|=ۭԻvvԸ Zanp{R ~ xkpǤդJ |MOh7xvS@0k'CS<o>+ nksۂ?M#ڷu\oyP3\ptCҝd}Hh=E/.) Cl}JUϗ ӵW"wVm?3D+HinsNf\41 KK9%a$!Tҿqv3CsRv)ӽ[mzScF[LMUlW\mVŜmPR6R4ɺ):Z-j#Z6>Jx}Ͱh_9\P|K)~*3wPj|6Xe"O,-v:깫n  З["˔WTR .'Y3UXD*\RJ[LxԲ_WS]hXOKmpuӺ3䪼6l-1Ť#;L첄`e fi.k"֎gR .f s^/Gsھ;R[t6?l?OWbk[mw8^U|6j__)asQs4]|7̶;F^N}|̼XLhLZ X|޾%ZklkG5WRݒs|5ִ/Oh"MfWLX8;{z!+a8T]CfK\Z&5m.PWkz7Wow n<W>yѻCU`~{ku8wJI]!$SRkKKTY:W=CJef1f߰}-okȜufѷ7i.+y(ҷJsn"*]=[f8JKB䉊ֿ&,DF,3 &gE +aφ7FY#_İČHݏm* u#B|}nKFXǰ}gR>)H.RO yiwQFn$Jz5.L\eƟ=۶F9Bch gpI9h9n1`NB't? u8fsd6W~2h{>t|@ǵZ{3֥f'XuEs)Gր.'MyMBҝ:ע~xgúw576Y,p;6=tM q"J3^hZ[}Op_Rޙ?[o]n-oJU WO @pJF#Tջi пSOF#J?~M0y~x_nkw ^UyhH!y RulF;5m73ުuttN.kzZ[r2MH%ІhirD=5RZ5.JM;. A$ںN~k5t[_yo'dgiLĚ;c,/ ah1M=GQ#jFsN}uDr(P?Vи^;m r)Tk8|`EعVf=uLc\`w6ld@rAi'Z;#DOgow\b-7j:M -4&{#קx=懈Ӳ_JKI8bm{U$ٰjt1c.o}Km垍W-h{Sk/{x`q]'–_=j3;e-nߨN(6f2lf9jjTe[Av fk e; "cmw9WGu<6, k}i x}tmsg׆?:?sGzo~M{~R1I^91BHVXx $dQ r; jFm9jNo?Q?_{O6%\W?ݩuۥMr=-]cl=Nm{Kx-ֺٿIcb(×ˮd:@K?f;@UwhY_׎omY,?]|~oU8 M'<VK-GNtASTFmq1%Y7Yd͑yCIc ƩQw~ /vN1O\W)=|FҼO^rs5ڧVM[h*\ GH$x3:ۚJ>𦏅ڮ0ofqomNkuXe7-dx?/W%#p⻹J4WeNU⎮nŎ'L\qJ@9&ZKw!/ΗGX菭qi;W)Rwjli.Fd:[gc[vqZj䵢*VjL?5w]y.SD%pOz[\RERO>5rU(VZ9CUKm]ID5vUĩFV +/斅ښpi~kbrM=#C֕ ;F jmJWԴԺ[oK{kM2l6+,<6;HԘ|3BA<Ŵ9h}6>h m|# < ""AjZKm_p:Zv9>u{GuiIe̾Vm{}J}+=? %:%ie p9kutӒ3ǡÚgL/ XJ)hzQV:Q3Mf$dIEf~!& t3@ūQHi0(5ґ9is, 5fJ+.q(G5 VͯJ_ }L_#7BXLUU!~;b? /m؃S75@#KZbVfu(Wb]j!-_/QоWuĭ-w?f'Om]kM?53*GF6YKE khN.IMUZ^%ZU@6:cu|2q^Ecn|䙮$#kj.Mix_!e7)i9jFd4QVJò#[^R}/_ixk'_GϷ?H=Oqt9߆+x n5tKZi8DӳW]kb䏅RyDsF 旋]|;s[W}^_|aBֻ:cs?ҫξ~R7Nؾ10|5p^7.W8 ,9}t+!bO!0u`wZWa?.p?I\v! 3SP JNWngFs"Rb=(V޲3ǁB9<%J_l{#÷_pjZzc^د7^Ŀxnr9[M}/¯ۍ:vˌ)k?ZNݶ\{K@ثUTѱԡR|ixM]kmԺ[sƺo:举wX]uSڑ>3aT.$.KN;u|hݥ,,]c9%\J5R$s胊7](Zu5,׾QwcVo ץ.yXܝ;W.גDҕ(]k6c<]v6@«5x uյ*RNz=[ R2E' ursғUqR[.B 2ԻmrE-k5;-ˈp!(ԟ*QnLv:="+/_}[l\OZZ˵u-U 5h0\1Y"5UB&[С3_g_~Y}ښlNK=jKf:ZqYum7f`Y)p̛u+M9-j{ wCDYQ *# \uoT"E:ٻ^̖ [ТJ(a^2q=g0o!vĞq&X\`EmP42f@O>ڼ¥J0;R^lI$k@5u >5=#-ݣUԣBA)0פֿvxy,Y%ڎA7cJwTv~n ~4u.ۧlztsMvn޳,Q$$2D#DfJ;CUG.RuFzWG4?<%^n;gۭtn]v;Oz*x ]=-?j93f@QK6:ODjC$^eJ\ Tnpo~/Sݖ]l[6dOn5ݼ݅~ߨZ^y,- UgźƮ"1^6ZT^nʔ+wl_o p9lxOiĶe:'^xM]y[b;1^Ivqե44ԩU5ly]=}itv÷j3(x{nYsHKZ(A8opVN8RR.6^~,e=GW)}v = mG,s%zNCm#]@d,JQ]sR[|9}]v|__^nj6k^L =g LE|;hoMW[ڴ47 `/=knߌRyj[mF0nQncR#+}kx{SԹ⼗^|5WOR7'#@#ےq&xDmryyv$ahiJӼ5ԹdxZݧskܪ 8NH-3ˇҫKG{Vj4tdhǵGnwqeL]8 k>7+Xڋeo|+_j[ihe[uZ> _C[͡i q=b$aEfӺ45@#' $uS]?G"Vf79꺺nR2;{}nKOSJVXZ~{ndjiuڶ.1z>'kh7ؠH(H UXa+ R1Q h8*bͅ9hElrj^9W~/Lͭ_q}{S ٮl7u O]vxkHdvg&jI:ncϒjg{7O&i=\my{/qZ>#e֍qq{2Kyi (M^-׺?K3i_R75/^"u.-w(4A))RWg{.>*ʔ<@NSXu50^Q̾_QfQ׾ l^{uuvGIq%oնM@k.\JwPSlFۢc14dԶJvƥͫ!ZګyimJ9 nKW:^5|Gd3k{OKxg\.tZ7Z?}6X!tl6Bh,ܭ~[ҽ|C1xv!$l4*U::7\mcz|N~>Nۻ]izז%_sٞ6[dpv-½gij bL5;\;q!㫮ԭ^r\]ᮟ^w7Ԃ:E=t={{>TqOX ]H-P έ;+ѵԝMKx [xj;M_wdǵt>Գ>M+n;wqے=My*rq fJY\dCAoKR_u7MV+>뺺2X_Yxٶ_exWGJ͖o7$rAOnƝc^Pnu'KpGe2h]f;؟l6 IH,if45!|׌k.wjjyLM/ljx7KZ~8p%p)ԣ]qimbs*_l[qY{maғN)cj,Rn5R$meRݚRK޾Oo9#־+/njX^o$YC4$ei =ڏa[ i Pk7vmejy{X[ˑtn#^/⵵tY7E5T$s Ms+lpN7hJ_{{o-OO/-~Y>nҼmr̿N=Zݠ71+ }5PڧA= "x:ؗf ڝU:ha􋩭JwxhoivnZ?onvy0;*?_+4l>1!^]'K{L7o@^\l+WT=aoX"ZNWml3I~-=c!uz*S|vKKvBUf:Y\M;jtN{RcblSM C]%g3 iJ&Z`M741k5<,u/Ѿ;,[mv_-. Rm i6Գݻrtl2<0nJT¥J]xLۣu10`=W4 &e:3Hy5MJ~VlꒉCQ;ԫ-]; b=^uWZ7ۧpw5;tZgW{Pz`u䡓!va(uKq[eZ*7DFy>5\E[S(iI`0-AzR3mA冥W[ETmk]U.$PQZ:RH PYۡ3_ooľ٨[=W¶mcun׷NC( QnUcA1b[Ҙ`. PNgWivdݞz/}/,_{Nnѻj6"~G$n fֆ;+s'rZ(Z5( ;F7j3=:o ^ kA0\ϼ,nUCRB6ܺ$pdW.EABJQ9,N{I*,h$o23 Z*U%pN gW})(tns$+M gqs*%viE1 @K=];jYq1^'|E7۔xkֽ |Wnݲ|c)jYCBIP]јsE8tda$ڕ8CY;HmhFÑf\BJ$NTy|A55KtAklmd-+fոjeQnJJvn4)FѤ@aT꺖"OZ{GGFKݖs;vtQH1TD_FsG0pֆ = P쬁3JENk}lhCڞ5O!@4 Օ3JU*s^+ =KV9[[=O uuŭ1ߚ}߄źۈk<4hc#/[]76PB;zT/ov'OJ뭷 Jo=|K+'5>mq{tUh{ۻ0˚lx;ڨoY:uO.8~O}fj.RjB=澏Q7VzGnVW WSǗ7\ +(WѺRm\]jfЈzUZpP?-;$l)bckF9G[E*VT{sf>us~fy_~3O#CSZ&q/3l~x#Q;tЀwhy[Xc9P PWONmmXX6[f7Y͞Y:Ykk^4eP`&ÌXG $'; 'cn@# mJT^ڗ7m mz& 3x{gm܋1\7[6kjZLu54nj]/jfh-oF9Y97~B9}P=Q٩RJ pvBYZ/ǚf7x|fLKt$7riTC°;<1',|b1gRM(MupT OvrT"9G%|{N ކ' u,fGArd-yZs·E^jߢq[u,n^G:VKF6il\ p]s#;Z 66ʖ)LPvϔ)uUvs֦8VN @{[a#Jk<[S ̅ʜig ϸL^˱H4Id:5Rqu0=*F۵-)5U׶SKVuPc:CTlxP7! v&1^/s%yJ3og{C;OVlֽ+kv7(-RM^-sn^c3dj7̴I_SCۧ_im̝$ak#`09angk{(h7G6y5(TRI 4uY:x$&3j;ԒF ``@՝QyRcKt:8Yk(esxb(n""^ u@qzDzsAC$meP("90¹o]e5cÚ7WPgINkcq|[@$@' NSF5^}]+p.EGylcr8v'oۦ/u:;hk*6H${rRcMu|0moR/45/^[fA^~]+x5]nj':;싒?/馩>4*_G"_J>kW?G__Bre *T) Z f抁7 kPC,4Z*T_[<6n<;wye;q-{}[}m#ٮZFQ*\ttldNJ֚YRyHh$֫K46A)R~  oedi۩V`)|F}uJp5n]m[m uۮ]!Oc⾍KhݥB<Qk\+R0ޥ–SNh6Ѻ %UgGBFԣJP=bvni3ˁT]!ȚVJ+7(q;K}b,1Zy0" BgdҍIȵ٘ckUkhk~ ]=+@O֚z>: ];aWyAw.ppNBԮwH)K_뺜AԶ$:*CNY#na:)ؚ ׍2תTOc"(j\t:t ChsJX!iqnk&`=|ƴJ3 @8x-\P)i N  I|X.R9Z|)eۧ%* ^W ) :P#E,h^]( L7nD澇,v}_Ow?~$ֻu{sRXApEޱ[=o7|jԳ YMHG<A3 l7V߈,zU&3^{4tnRxYo-k8:ξڏ%SZ86ذ3|ATfl؆ ɰ &Z^![Jkn֣>m@0XĐOM`F8 F-J) v]$(jҕxY$@S8 Ԁ OyaG/J7Ye[p9)0Z=j @(O-Az)R;u5Aj<Xp r%ck%?w5u>zc=~ŦlڶguʏOki{.Mm[w}!X=}~v-PF"gvvP2Hw%h'`9bG^H(x#?Z~pdyR׍]{-wnCq^,knnZ(IIep=\F%؇Z(Rihuh}+ޏw7m+z_hq54 ַ7o(sD lh14O$M#[@R(Ext[XYɘ|+m]޵wkꚗiZ؇DsK/t-_KSSu׾6 puX"G#Mh5NlIS^6n[h۩uv|ڝc^Oyt0exo5u_m j_`Cjs(RRߡ*>H~QJ (K :7CVۛ{3| vn?qUuه0Ee +ѵzMvmX i'Ty*p%MԡW7eyL]on2fz~3N5-vu*s;)C% ^wUWjvRyпZm#}l~Aۮ]-cӜWOݽ6)۴CrVJ@w*[+Nun Mu6iۗ*PոlͳF+={S;gL G+9MKt4,Gu+wz wviy=+-M[v#I/Vn/EO 5#PiJ^|NOƶNXm׻Tۤ]l:R^z%tv`kkmGb֋,n~1NHΝSTq5NRvo5DЩ^iimLJo(tkcJfOջWWUi4]noc=J@nCPž׀[]Nt׵@В g䁦Ĺ7xRtی)QܳuU:zÇ8%iv~82+Kde1M4Nh Pt931=ٽ]#^@ԫSɸ $ MTטS[^(sBs^ݬZ5gfɭ%Hd%ڨ)B@GQfmPҜ]WJMI!o~7d.Jt"GY)YF/It.T> ez+?H\=e*P JѧCwDQ=j'5]hb 7_WE'JKV+ϥ}b_w~, ꏄ:GmgdUAӳvV#J[<7ۥxKysk.kWW5P g8 tJܢ0wob?^лx[m_{ּSR.m\`K> uPX ڭdO5$9s`tK,RI +ΌwgU(UV9y\j\M }/}y0Rj{#i#$J٬M?#[jVHs\vaEJV0͎'tެҵ]~duu-AiƝ\ )E#JG=sS2*S[ia6wh6i;Yd&˧Dzs3\xY3>Vx#u2xf-vӝdLvWa?T4/ֱԹ6cTq- RiuYquQ{fք:MfhK )$W]y\"Z.n LOu&;a4i/Ʈ.1Z$d+BM Q!hH[ޥ-VԹ ׯjV_^Ա!;Nk}_Ҽ"-%W%)@R}It[]ZZY"4CuXhR,d5UvmV(b HD-f\3^c72Д18s:moԠޟ#ěe^alvpz*x٭:v[}-ql:]t}oq(7H4Qb%uuJq-i.ԺB'!oO48 UX%֯g5@9`ft:s:٩5_!uz+r92jϨJ_z1d m=SSr;6 _>`AsR62ָt\--9n k׳n~ 4ҳ4S*QW7ԩSF)H AfCһM-q}5u픡SӻOr6t@mKjn!1!v)0n9e )FJ+9Ěb2[F)E4&ql;Li ݆>IJ|.Ѷ^Q\ޭ5nߡlY`}+VR..H0sVaQIRZvPdpRdͰq0P qcK_ [}ZaJwK툎 D\-|qmYTVsX*P8}*TU`71mZ/\/vQIF(lqǥ!.!kإphm@3BI)3NÂina䰵bl.Lڬ9"oN)R۶*j]63کeҚ5t sޯuېLSKlalFF@b*>3FyH֛H.^^;o4lHoƩĀ4؂J)VZy#J"#akJ ƜK!7<L2;N墔hC]'|9&ӎf1_+h}'[KJ3}CrK-13㕭`(-PtGOBYnxBܯUjN5mN~&d1 >,<c~/Rz!r]5RfĞJ8%f= Mɮٺ;jxHl=%_پ~}ξvZŧziN߱K9#@7'Rk-y3*Ty? i_ajZU nXݙ^~5+MsGcĵ EyzHge>xGBX̍Tשm^QZ][B &k a~eis 8?Mdݯe^Xpp@w*|@Ks'}?C [ g۪[k3hϪVJ=;sކ;oMwӸќyH7 ]eBlR4jH:69 TTmsl&إ.W"Կ_Njfnx㬕 - '!-;M.WstQ6_)R]|[EV7mj=ַZu([uHKK@9Ё_v \f{*~I~%:S>QM䤵n:|BK۲sϖ R5Okj' j=َm)[KLqp=]i -츢۶ݬ?}u挰oD 7Zy tNsRPj[}2zW~ ݩw]m-/jgx+Z]2j}FP,0Dq])ψ5IV6CHR&":Qk}gW?Ƶh{[~KBpc")\ y(gA qRw߶*g6Ù^q⿀}ڟZ&ǫUOCHn37qrsP1N ramF3 u?KEn(1wT F4 M8>"uuI~5ֻhk2u>"}_o{}-1 ejNEҵɢdc#sI'B+{#5wzfPuۙfK fn5&9<_M5i5C>3[6mpW|[^웵u, _R 㽳ut oD\`uXo%fʒS+b<[!Bl1=**f=8/]捦1I؄D7@].˕ (thT޷R71yuQ Zt Iq mԩBX 63Cj^hpIdܓw0nRHVhmE Fm~Zcl i;S B$ vUD2JR -K/m n*=`mR2Ohu7iYVYO$ޥx!Ϧ:(չ&h`4ڕ* ^_J@=*^OT TlۗZiu4h&q)R qFwjO>OT\Ҿ"^oc-+Mmӊz*s[y54i!Bh!fR)y(jb)fи<:7+2a*gLkYT}-5Q^luܝyIA:RʅrHtGQ =v$ *S7->ڸסR2G4jy29IYv[ {zKTKG$!3ChD@ !jEцskB'Ce{ ϐg Muέ/VE%x?wѰ[/;8k'wSc{D*%ƫe^M\>"&w XF|ofi[KV *֏e7iXjnDb&k,OiY/㈎ZiC\,]R{]s E7Jq=CqDQdnś)Bֻʆ+hkE}s.УRܖ[Yz̾.]̵ - ŏ YshUtID(֟ ߩ~=0VVnZJS45@=UGb YWXDXXhB3R6ܟeǘgpbC^ 5آ~%ڔc4lmT`knk.h,#:(=n- ۵Wֳ7+8D{sC&5IJn7w:B/S8 36@.n6x׵'Jka8)Gְ͎`[rATypEߔsyv=AlQ!ڃQ )^Lum7.6 K޾mj7[nX?-ec~fŶ/MՌSxߔ7_s <HĒU2=ci5>MKVjilԶI9Ѻͻ0bfik;4N*9084Evae7t4Q7c+|VO ҶmgZᵯ4T( |q`nL;uiE>#.2V:kj#M¥˒(ױkl;cڄKmzvk^ nӷSWVlV_o55Onѹ8Z;ֶH?3 $mN'g8Gdh}e<,2CkU}]]Mk.o幖|Y3ҒP|-lB颭 F0 e}GB$T4lE1ҫYn94"C'(kR zmtLaJ'٭I}OMtWjx]Oya-3kk/ښ fb*l+GnB-:&LVg;#~+WJZ:'%mZm}"nrg  ~1b|ئc+s7ڠ 5Fz'mr|l6hߧy@uVzz~ ݖ.~{GR-K8kA*:ږ,!P~複8XWD0ءBWkiKVUV}]gmǔuN|ߒtz4a+^|Ԯ,&m E*Utrz#G3ӬQiy*˵#IhnÒG Y67uA)R鍸ҹsz'1-w#V e1fK,$uUBɘ2ttR$R1֟i[nY5vu6܉9 Mڑz5F(%9OGJ t)iA$~F.+!uԪk΃N9;[)R(8mz k n!%itJTҼtm dIs>i4rJ[n b:3DD c)ީ$srzSG9 9$u*Q N*Z3jIzt4FgڹsVEmTHqjvm]->U#5i9aZR|Bjɡj}M+olҔq~2i!p&=v)]Nf{Jۦ،[/)F mԆBoA~8eQ⸓sJPLeAUDztlnӸS:1$lh嵡)!VZ4ti##3{pX\}wAm9fZn-bc|Wᇇ&7u,]+{Eй y"a`0pA{N-n"LmGּj+{s55[ص"ӵϻwf>aƇRtb:H5܅ +SUFVſi[m4Kk`RaGH ]DvB 0@= ܴjU۶.nLRڑv9AV~tEK=54"RZzf#fʹ1 de.pt.sKG*05(S+8>490!#s#/p56.r>0sw#H5NД2SͷuRVu6)ڪH\g,q ]e4CBٚ.-䘞h7AԫhKiM+gdBcNZ>uMXcxI#@AD80il-6fRh"x r&kS\:zöYmƨYw3*SN>,KG܈F>pgph&kK[6nۣ9'x;!ںb{pt|ᚪɝ #y>IR9,: RQ&jjŻ;WC klΎ׸=kutmx^is4|m6۾-B`C#$3DN;~5 IMHK4 1UR$`(8KD|,rPcE4;R:f}ޭBzվBS2lD~@KHAT9Ʒi0]ʥJ} E5Wھֺ-/& ̀X4ЧָȮ[Ef݁WOO$Mr*7]nnDD]ybG}=m;InMrz`䟇Z.KNWȅOl9aHi 桷='Mv\I_G̻ZE1CrMFfMhV/`y"xYnN oEP8| N()ݭ2FF`_Fg{jk5tK1fßk Ffd|ȣɒɫ*Ѝ*R7+ 46ݝ{С\}jk(nL@Koe{hl(%A%JѰQ51icz aԸrJ~ڐˀv H~ULQzLxv]4H[Vyj]ԩOcl4_sU؅w;qZrڞ{XJkOsf] JM b]B`R۳p53c-`<ƪ DK{ߪ͌q&"@LsRV_-}%ۋk1Tݜ1hN cQh lr5ĸn nF^#mڰJ{S `h]du~55%^\g#4nf' AiA%,4ǤRKljELE,J6z!M7яJiIt-wob胩MdH[ZQ)֏wTpvx'RK?b G6Pv* g6aI,.̡ |*T(ᱱr,V6c3pvw1~~7T. ~J*QOL4 yDŽc|c,Ll!9!1hʭFVԛM-?mҸռ./ msS۴Y揊bk^QOL^#񚝯mGZ^G 7,VVkdpLc&xWA`{Y1']bȃmޥt$؃i1JzZ:7jw+j^jj'r㊪MmKHn?lԚ5U]FV(ݜ %5JN4ږUMh1FuNvwCնtxR7@J zR Ҥ6*#rl9]i ,v1p5i)ˉ,(pJ'F8KmsW:ۨ$Fes)KѾU#Kp9R2Zzc!m<ֲ(&3Z6&[#1A]( !q4s9;5R5ĒNEs es\@ROzSx.gJJ")c]zP[$Pn|UzWc<8ܪsDӞ"VF<k=R5׻ۭlս[x/ uYGCRt>۷Aº`[V~tw|1P3Tv eLmnTc-J}&E|ErOlo.\zW}.6i[k,agw\>nh#Iisew XfI7"0X\\\dz~ַuCn}r_#>h/FkݦKxk綗 ٞv.4NwVP;nԒƖ$ՄP[j(9+9Oeu̗ڵ]])[ObK,6 5EJQ=([vcKCZ[RhHf͂6SX)R":Z~[{&jjsOU ӱ5k(Ui,cwRwJ?* ݃%mYn8jJ $`ܤ{#$聲I=T L}3*M+lKd>tVO5s H36u ßۿ%ϊ4)*T ٍ=Z uJ/UwI3KԞ(kך5Cd!J4KCP3RnvՙyHȃѱ-iNmMjnw<+klu'+8dB`lﶋ3iXu 7Gck=q~u+ m"'F.\"w{CXć-mxnU:?SDm4.-ashqp~؝,mj9V\y4步Tڛ[F% l.9 Kͻ0 GIQn܍wR`s;GG?5b[uEC3\K-2q#^Qxhı0VﴩRWnMֶ֛J1+DL48 J;oZ7BNZ ]=T=+EKKnv] rdUEA4f+/f3jj+\/Sv05`vҒN*V%' iI0Ҙ m]y@'>jwgclq\x?|mҶ˖jf=ƍf;茝]َ`JM"/vg8nc6[jt6=*xK$hp +Q⸬55X(ֆ巊kiqj$O1b>^D3@վ="۵$,@ӗVЦ+Zk41귖''NQN-inh# 9ydhLui䮛v6za2GGkdž}ҺO+[<^[ɣ bLyUZ15`0MբJ'L-%zi漆 ĐFfG䟕šP =J,tx;`ZM^D*85 t0`#1ԅp\gd % ) }-yc.;?,ҕbkxiјfHYk WkzkAJpOWp=^%Ȳ}͡q؊ ߒe5tK tq6SLn4,bNօb;D*طj[`rIosKW]'jY7e bu_ʿ[[.<7M <612LsYj=MU85W?_c4kG^ #q7GᇈVJKښ.FDkkvvˮfYniő6.zPhRafJך+W.!5*2U]AźPT+<5рПlwF0ksگSa*e KvҭxkOPS5J{-SP-& ZRnٌq<Ժ`#,$28w&949sm(H:J6&ޔ-Rmdj'ך+P"nbb.sk`opqD"~^h/ aݣb%?k F^m/CF+6Xhn9*3n,B$ nP@q1-u9apy)Q{5Zұs5:xݸ޻ox{7SKSM٨^YvhdihNx)X.)N [ 0ӷԎm.J,pV|OY.oW>EU>* i8 hxHX<֝T4 ;dzJ7Aԁuںţ#r5 xvCƎaJTݼ-aq?Y#+U;RE 9t;k.{jӤFJ,LZRJk6|hnc.HH5 n.fntԍ4(OyLޔ[|~z Ťwȵ/F!ft[ n_q=bO{I HK\5~*SOvgUe'8hZ#?׽#́nRNEQ!hs ]ꍼ6z_>˶j'JTr]=eǻP&h%pkɽ OцuvV#p55Q^ett1ҠacuⳆ>RnZ#ys A֥>W6--0Fs Golx;t8:Zcy: U\L-6 qh{MݛFuݫeÏv_OSKs7:EvVg5/^Zv:}a>Oek9c |-ފ8ɉl;+-޵aJZ7_~!c1X.⯰K_nn+v.L)HӈBd˜KRF@ze%r(!Rb_ZVػhh<✻d@07CI|uO,FH'tF#S@ Ck1M6(]-})fm5KV|\4"ϊ}9{R'GrR5+FkGUvI= :]HrAohMွT$y54J{wD:i'E' c/ZjA oQF=k;\J L4'E-_B͉foEſ3$|+%hm2Mߒgú:m7X\.+wE>_ {/(tٲLTTZiK_xReݣԶ!T{oz^7i]u^m߭_N믵oqrGÊlԶ'CZ1"XĀ֡Y$HrNf0\Ai-ffLM ЏBC[6W55_Z^ж mkn>yw[S٩8}>UΎxf*FG.XEss+BY`Gƪ~HԠݧv/Һ |G/S6jaVÊ^VACl *[| ѓd]1#^\R#ֵ6ⱺk]%Jfںf֯ }7`+wfWjcV­Mg_OBAڮn/B : iЊ(&> 9Db]>i6:cϬnL@/IwvM2Hp@< CԴ`PF n8+N Os(i)pNcXuTr߇UݑqV^M5(SkNēmԳ}cVK.$F2|nvgGwQfltR*B3R>`jj)l(cEnT@$SP%tBFfީ$ph5~ZWd4#[3'AJm=ӿ1ev۹BۮdY!ؚKKNǪcpaܧ08ݑ5}e6nkun7_S~ٻB\7|y`]mGL`- nV#!ekD[4Oot*̍k}(ToK.-^ҲcninG^cVK[/JB-e;ȓKQsz7 -pt#Af5^9nt-wm#/|Wh״>ߛدP*b^3WzsZxw :T;&ܭ5Q^b1Hj=*74y*8x`Gsu*i~uR0\Yn~xܤN+^m?-s'tG&lN)-z&Gis?u}[˳VInuW{~=mqs'G<ԁdY-k [UƁsEh v]w1XKtfZn}nްid'GWq*NíΑHX T!ϼT %E?)YSUw2|{?s7#ѯ\gr*V~X.!lx;`VTهo4Z{] Fqsf_l_u&Y;^h`k};VfckoL@mIaP6(+FAD nW.c~R>΋Jeӟ/ j6ho%*Th[EV:%gY-|?l 7税K7ǼXڨM7ǼXڕVH_sG]=v颶x~J>"^I+~VMU?uzSsm@ |]Ptr?wJ?~5z#zO{a#&bӶ^C >l﬐_=h'šOK kIcς.g*Rܮ(t(A cC,mmެ7eAJ4(>(XޛoJU&'ޢtAJnbsq=ƒ߬|j<@OL2 {Y#R}Ӛ}c::ɛ =:FObzT+uji;\Wڮ7v3ĸ:Ԋ2hY"1R|M=nm#fß䡧?;\A y#lO> Thyܛ'/>lP@Lqa V$o|R% T =_K>_u :JRNڟ,oSOLul (}dJjnդ?E=kVbuiv06a;?召TMfoh^̾tBC>q_G#o%ൖ\IJ%xXC׵ endstream endobj 987 0 obj <>stream endstream endobj 965 0 obj [988 0 R] endobj 966 0 obj <>stream q /GS0 gs /Fm0 Do Q 0 0 0 1 K 1 j 1 J [0 2.997]0 d /GS1 gs q 1 0 0 1 74.3631 368.0103 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 71.3661 368.0103 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q [0 2.997]0 d q 1 0 0 1 74.3631 340.4025 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 71.3661 340.4025 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q [0 2.997]0 d q 1 0 0 1 74.3631 171.9176 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 71.3661 171.9176 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q [0 2.997]0 d q 1 0 0 1 74.3631 144.3097 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 71.3661 144.3097 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q BT 0 0 0 1 k /T1_0 1 Tf 10 0 0 10 70.8661 724.8299 Tm (https://doi.org/10.33878/2073-7556-2024-23-1-136-141)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0.023 Tw 19 0 0 19 89.5984 695.3259 Tm [(\032)30(\215\f\215\007\205\002\001\025\016 \215\201\r\025\016\001\220\016 \006\220\ \202)10(\024\025\r\220\201\001\025\203 \n\220\n\220: \025\221\220\006\013\001\220\ \016 )]TJ 6.632 -1.105 Td [(\n)-10(\007\220\001\220\017\016\006\n)10.1(\025\202)10(\025 \006)-10(\007\215\017\013\205)]TJ 0 0 0 1 k /GS1 gs 0 Tw 14 0 0 14 70.8661 649.822 Tm [(\003\215\006\025\r\013\022)-23.2(\037.\b)-31(.)]TJ 8.162 0 0 8.162 141.4713 654.484 Tm (1)Tj 0.023 Tw 14 0 0 14 146.1073 649.822 Tm [(, \214\025\202)21(\201\013\001\025\r\022)-23.2(\b)-31(.\004.)]TJ -0.069 Tc 0.069 Tw 8.162 0 0 8.162 235.6299 654.484 Tm [(1,)-69(2)]TJ 0 Tc 0.023 Tw 14 0 0 14 246.9505 649.822 Tm [(, \021\026)11(\013\002\n)10(\025\r\022)-23.2(\030.\035.)]TJ -0.069 Tc 0.069 Tw 8.162 0 0 8.162 332.7917 654.484 Tm [(1,)-69(2)]TJ 0 Tc 0 Tw 5.83 0 0 5.83 70.8661 635.4827 Tm (1)Tj 0.023 Tw 10 0 0 10 74.1775 632.1527 Tm [(\210\031\214)21(\036)20(\240 \004\036 \253\240)42(\002\013\007\216\006\n\220\203 \202)10(\025\006\215\201\013\002\006)-9.9(\026\r\016\001\001\020\203 \024\016\201\220\227\220\001\006\n\220\203 \215\ \001\220\r\016\002\006\220\026)11(\016\026\273 \005\220\001\222\201\002\013\r\013 \033\025\006\006\220\220\ \(\215\007.\022)-23.3(\033\016\221\220\001\013, \201.\022)-23.3(3, )]TJ -0.331 -1.2 Td [(\202)62(.\022)-23.3(\t\n\013\026)11(\016\002\220\001\f\215\002\202)41.1(, 6)35(2002)35(8, \033\025\006\006\220\205\))]TJ 0 Tw ( )Tj 5.83 0 0 5.83 70.8661 611.4827 Tm (2)Tj 0.023 Tw 10 0 0 10 74.1775 608.1527 Tm [(\031)83(\b)41(\240)31(\211 \021)31(\036 \253\021\r\016\002\201)-21(\007\025\r\006\n\013\205 \025\f\007\013\006)-10(\026\001\013\205 \n)-10(\007\220\001\220\017\016\006\n\013\205 \f\025\007\216\001\220\227\013 \023\ 1\273 \(\215\007.\022)-23.3(\004\025\007\202)10(\025\202\002\013\201\006\n\013\205, \201.\022)-23.3(1)112(8)23(5, )]TJ -0.331 -1.2 Td [(\202)62(.\022)-23.3(\t\n\013\026)11(\016\002\220\001\f\215\002\202)41.1(, 6)35(20)87(1)75(02, \033\025\006\006\220\205\))]TJ /T1_0 1 Tf 0.156 Tw 9 0 0 9 119.0551 577.6488 Tm (\037\036\035\034: \n\033\025\t\026\024\022 \032\031\030\013\025\017 \013\ \023\025\021\025\006\031\t\013\025\017 \t\023\205\006\026\017 \205\030\027\ \n\031\021\025\002 \t\025\202\003\n\027\025\030\021\n\017 \013\025\001\013\ \025 \025)Tj /Span<>> BDC ( )Tj EMC (\033\032\n\027\031\t\024\025 \030\025\f\f\031\032\031\021\203\025\026\023\ \022\021\020\017 )Tj -0.013 Tw 0 -1.111 TD (\030\025\026\202\021\n\016 \003\031\204\030\205 \027\032\n\204\030\031\021\ \021\n\017 \025)Tj /Span<>> BDC ( )Tj EMC (\033\032\025\n\005\032\031\024\031\021\021\n\017 \033\026\024\n\023\n\202\ \025\031\017 \n\005\n\030\n\006\021\n\017 \013\025\001\013\025, \033\032\ \n\002\027\023\002\007\211\031\017\t\002 \013\026\013 \202\025\202\026\021\ \024\t\013\025\017 )Tj 0 Tw T* (\030\025\027\031\032\024\025\013\205\023.)Tj 0.114 Tw T* (\201\037\215\036\217\220\235 \215)Tj /Span<>> BDC ( )Tj EMC (\240\036\220\255\200\235: \033\026\203\025\031\021\024 \213., 45 \023\031\ \024, \021\026\004\n\030\025\023\t\002 \021\026)Tj /Span<>> BDC ( )Tj EMC (\023\031\006\031\021\025\025 \027)Tj /Span<>> BDC ( )Tj EMC (\n\024\030\031\023\031\021\025\031 \026\005\030\n\003\025\021\026\023\022\ \021\n\017 \n\021\013\n\023\n\202\025\025 )Tj 0.036 Tw T* (\025)Tj /Span<>> BDC ( )Tj EMC (\013\n\023\n\033\032\n\013\024\n\023\n\202\025\025 \210\201\214\221 \207\ \255 \207\255\222\213 \2461 \202. \036\013\026\024\031\032\025\021\005\205\ \032\202\026 \t)Tj /Span<>> BDC ( )Tj EMC (\033\n\030\n\016\032\031\021\025\031\003 \021\026)Tj /Span<>> BDC ( )Tj EMC (\n\t\023\n\204\021\031\021\021\n\031 \024\031\006\031\021\025\031 \030\025\ \027\031\032\024\025\013\205)Tj 0 Tw (-)Tj 0.071 Tw 0 -1.111 TD (\023\002\032\021\n\017 \005\n\023\031\016\021\025 \n\005\n\030\n\006\021\ \n\017 \013\025\001\013\025. \241\026\023\n\005\020 \t)Tj /Span<>> BDC ( )Tj EMC (2021 \202\n\030\026 \021\026)Tj /Span<>> BDC ( )Tj EMC (\033\031\032\025\n\030\025\006\031\t\013\025\031 \005\n\023\025 \027)Tj /Span<>> BDC ( )Tj EMC (\021\025\204\021\031\017 \n\005\023\026\t\024\025 \204\025\027\n\024\026\ , )Tj 0.217 Tw 0 -1.111 TD (\023\n\204\021\020\031 \033\n\016\020\027\020 \021\026)Tj /Span<>> BDC ( )Tj EMC (\030\031\f\031\013\026\203\025\007. \032\025)Tj /Span<>> BDC ( )Tj EMC (\033\n\027\024\n\032\021\n\017 \013\n\003\033\022\007\024\031\032\021\n\017\ \024\n\003\n\202\032\026\f\025\025 \n\032\202\026\021\n\027 \005\032\007\ \001\021\n\017 \033\n\023\n\t\024\025 )Tj 0.033 Tw 0 -1.111 TD (\025)Tj /Span<>> BDC ( )Tj EMC [(\025\032\032\025\202\n\t\013\n\033\025\025 \027\020\002\027\023\031\021\n\ )0.5(\t\023\031\033\n \016\026\013\026\021\006\025\027\026\007\211\031\031\t\002\ )0.5(\205\030\027\n\031\021\025\031 \t\025\202\003\n\027\025\030\021\n\017 \013\ \025\001\013\025 \033\032\n\024\002\204\031\021\021\n\t\024\022\007 \030\ \n)]TJ /Span<>> BDC ( )Tj EMC (15)Tj /Span<>> BDC ( )Tj EMC (\t\003; )Tj 0.055 Tw 0 -1.111 TD [(\026\203\025\031\021\024\205 )0.6(\027\020\033\n\023\021\031\021\n )0.5(\n\033\031\032\026\024\025\027\021\n\031 )0.5(\023\031\006\031\021\025\031 )0.5(\027)]TJ /Span<>> BDC ( )Tj EMC 19.321 0 Td [(\n\005\b\031\003\031 )0.5(\023\026\033\026\032\n\t\013\n\033\025\006\031\t\013\n\017 )0.5(\032\031\016\031\013\203\025\025 )0.5(\205\030\027\n\031\021\021\n\202\n )0.5(\205\006\026\t\024\013\026 )0.5(\t\025\202)]TJ 0 Tw (-)Tj 0.023 Tw -19.321 -1.111 Td (\003\n\027\025\030\021\n\017 \013\025\001\013\025. \215\t\004\n\030 \n\033\ \031\032\026\024\025\027\021\n\202\n \023\031\006\031\021\025\002 \005\023\ \026\202\n\033\032\025\002\024\021\020\017 \021\026)Tj /Span<>> BDC ( )Tj EMC (\003\n\003\031\021\024 \027\020\033\025\t\013\025.)Tj -0.012 Tw 0 -1.111 TD (\255\213\207\214\241\200\036\217\215\036: \033\032\n\027\031\030\031\021\ \030\025\f\f\031\032\031\021\203\025\026\023\022\021\020\017 \030\025\026\ \202\021\n\016 \003\031\204\030\205 \027\032\n\204\030\031\021\021\n\017\ \026\021\n\003\026\023\025\031\017 \032\026\016\027\025\024\025\002 \025\ )Tj /Span<>> BDC ( )Tj EMC (\n\t\023\n\204\021\031\021\021\n\017 )Tj -0.03 Tw T* [(\f\n\032\003\n\017 \030\025\027\031\032\024\025\013\205\023\002\032\021\n\ \017 \005\n\023\031\016\021\025 \n\005\n\030\n\006\021\n\017 \013\025\001\ \013\025. \200\026\021\021\020\017 )0.5(\013\023\025\021\025\006\031\t\013\025\017 \t\023\205\006\026\017 \005\020\ \023 \032\026\t\203\031\021\031\021 \013\026\013 \205\030\027\n\031\021\025\ \031 )]TJ 0.009 Tw T* (\024\n\023\t\024\n\017 \013\025\001\013\025, \024\026\013 \013\026\013 \n\ \005\032\026\016\n\027\026\021\025\031 \005\020\023\n \024\205\005\205\023\ \002\032\021\n\017 \f\n\032\003\020, \n\005\023\026\030\026\023\n \t\n\005\ \t\024\027\031\021\021\n\017 \005\032\020\204\031\017\013\n\017 \025)Tj /Span<>> BDC ( )Tj EMC (\202\025\t\024\n)Tj 0 Tw (-)Tj 0.023 Tw T* (\023\n\202\025\006\031\t\013\025 \033\032\031\030\t\024\026\027\023\031\021\ \n \027\t\031\003\025 \t\023\n\002\003\025 \013\025\001\031\006\021\n\017\ \t\024\031\021\013\025.)Tj 0.17 Tw T* (\221\201\222\035\223\224\036\217\215\036: \205\030\027\n\031\021\025\031\ \t\025\202\003\n\027\025\030\021\n\017 \013\025\001\013\025)Tj /Span<>> BDC ( )Tj EMC (\227 \r\024\n \032\031\030\013\026\002 \030\n\005\032\n\013\026\006\031\t\ \024\027\031\021\021\026\002 \026\021\n\003\026\023\025\002 \032\026\016\ \027\025\024\025\002 \n\005\n)Tj 0 Tw (-)Tj 0.116 Tw T* (\030\n\006\021\n\017 \013\025\001\013\025, \013\n\024\n\032\026\002, \n\030\ \021\026\013\n, \003\n\204\031\024 \033\n\024\032\031\005\n\027\026\024\022\ \004\025\032\205\032\202\025\006\031\t\013\n\202\n \023\031\006\031\021\ \025\002 \033\032\025)Tj /Span<>> BDC ( )Tj EMC (\032\026\016\027\025\024\025\025 \n\t\023\n\204\021\031\021\025\017. )Tj 0.088 Tw T* (\206\025\032\205\032\202\025\006\031\t\013\026\002 \024\026\013\024\025\013\ \026 \027)Tj /Span<>> BDC ( )Tj EMC (\t\023\205\006\026\031 \205\030\027\n\031\021\025\002 \n\024\023\025\006\ \026\031\024\t\002 \n\024 \033\n\030\004\n\030\n\027 \013)Tj /Span<>> BDC ( )Tj EMC (\023\031\006\031\021\025\007 \030\025\027\031\032\024\025\013\205\023\002\ \032\021\n\017 \005\n\023\031\016\021\025 )Tj 0.023 Tw 0 -1.111 TD (\n\005\n\030\n\006\021\n\017 \013\025\001\013\025, \033\n\r\024\n\003\205\ \004\025\032\205\032\202\205 \021\031\n\005\004\n\030\025\003\n \033\n\003\ \021\025\024\022 \n)Tj /Span<>> BDC ( )Tj EMC (\027\n\016\003\n\204\021\n\t\024\025 \024\026\013\n\202\n \033\n\032\n\013\ \026 \032\026\016\027\025\024\025\002.)Tj /T1_2 1 Tf 0.01 Tc 0.018 Tw 8 0 0 8 70.906 392.3796 Tm [(\037\036\035\034\033\032\031\033)5( \030\036\027\032\026:)]TJ /T1_0 1 Tf 0 Tc 0.023 Tw 8.493 0 Td ( \026\021\n\003\026\023\025\025 \032\026\016\027\025\024\025\002, \205\030\ \027\n\031\021\025\031 \024\n\023\t\024\n\017 \013\025\001\013\025)Tj /T1_2 1 Tf 0.01 Tc 0.018 Tw -8.493 -1.909 Td [(\037\027\025\024\036\023\037\022)5( \023\025\022\033\021\033\030\027\032:)]TJ /T1_0 1 Tf 0 Tc 0.023 Tw 10.401 0 Td ( \201\027\024\n\032\020 \016\026\002\027\023\002\007\024 \n\005 \n\024\t\ \205\024\t\024\027\025\025 \013\n\021\f\023\025\013\024\026 \025\021\024\ \031\032\031\t\n\027)Tj /T1_2 1 Tf 0.033 Tc 0.01 Tw -10.401 -2.617 Td [(\020\036\017)4.7( \016\023\022\023\021\027\032\026\025\023\017:)]TJ /T1_3 1 Tf 0.023 Tc 0.015 Tw 9.183 0 Td ( \223\031\f\024\r\026)Tj /Span<>> BDC ( )Tj EMC (\025.\202., \207\024\020\007\026\027\024\r)Tj /Span<>> BDC ( )Tj EMC (\202.\200., \221\021\026\030\022\024\r)Tj /Span<>> BDC ( )Tj EMC [(\222.\214. \230\031\002\031\035\016\030\027\024\036 \031\007\r\024\036\027\ \017\036 \f\017\020\n\024\r\017\007\027\024\005 \022\017\001\022\017: \024\ \023\017\f\026\027\017\036 \022\035\017\027\017\004\036\f\022\024\020\024\ )23( )]TJ -0.023 Tw -9.188 -1.2 Td (\f\035\031\004\026\016. )Tj /T1_0 1 Tf 3.501 0 Td (\222\n\023\n\033\032\n\013\024\n\023\n\202\025\002.)Tj /T1_3 1 Tf 0.024 Tw ( 2024; \021.)Tj /Span<>> BDC ( )Tj EMC (23, \225)Tj /Span<>> BDC ( )Tj EMC 14.78 0 Td (1, \f.)Tj /Span<>> BDC ( )Tj EMC (136\226141. https://doi.org/10.33878/2073-7556-2024-23-1-136-141)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0 Tc 0.023 Tw 18 0 0 18 106.3008 314.2332 Tm [(T)30(ubular duplication of th)11(e sigmoid colon: clinical case)]TJ 0 0 0 1 k /GS1 gs 0 Tw 14 0 0 14 70.8661 289.7292 Tm [(K)20(senia\022)-23.2(A)-31(.\022)-23.3(Ch)11(usov)10(a)]TJ 8.162 0 0 8.162 176.335 294.3912 Tm (1)Tj 0.023 Tw 14 0 0 14 180.971 289.7292 Tm [(, Ale)21(x)10(ey\022)-23.2(V)62(.\022)-23.3(Bogdanov)]TJ -0.069 Tc 0.069 Tw 8.162 0 0 8.162 303.8457 294.3912 Tm [(1,)-69(2)]TJ 0 Tc 0.023 Tw 14 0 0 14 315.1663 289.7292 Tm [(, Ily)21(a\022)-23.2(L.\022)-23.3(Stark)11(ov)]TJ -0.069 Tc 0.069 Tw 8.162 0 0 8.162 402.5093 294.3912 Tm [(1,)-69(2)]TJ 0 Tc 0 Tw 5.83 0 0 5.83 70.8661 275.39 Tm (1)Tj 0.023 Tw 10 0 0 10 74.1775 272.06 Tm [(Ur)21(al State Medical Univ)12.1(er)20(sit)-20(y\241 Ministr)-30.9(y of Health of Russia \(Repina\022)-23.3(st., 3, Y)50(ekaterinbur)31(g, 6)35(2002)35(8, Russia\))]TJ 0 Tw ( )Tj 5.83 0 0 5.83 70.8661 263.39 Tm (2)Tj 0.023 Tw 10 0 0 10 74.1775 260.06 Tm [(Sv)12(er)31(dlov)10(sk Regional Clinical Hospital No. 1 \(V)30(olgogr)21.1(adskay)21(a st., 1)112(8)23(5, Ekaterinbur)31(g, 6)35(20)87(1)75(02, Russia\))]TJ /T1_0 1 Tf 0.039 Tw 9 0 0 9 119.0551 241.5561 Tm [(P)18(atient B., 45 years old admitted with signs of com)16(plicated div)13(er)-40(ticular disease. Com)16(plaints since 2021 of per)-37(iodic )]TJ 0.099 Tw 0 -1.111 TD [(pain in the low)12(er abdomen, false urg)12(e to defecate. R)21(epeated abdomen CT and contrast enema rev)13(ealed a blindly )]TJ 0.058 Tw T* [(ending duplication of the sigmoid colon up to 15 cm )0.5(in length. The patient under)-32(w)12(ent laparoscopic resection of a )]TJ 0.023 Tw T* [(duplicated por)-40(tion of the sigmoid colon. The w)13(as fav)13(orable at the time of discharg)12(e.)]TJ /T1_2 1 Tf 0.01 Tc -0.01 Tw 8 0 0 8 70.906 196.2868 Tm [(KEYW)22(ORDS:)]TJ /T1_0 1 Tf 0 Tc 0.023 Tw 4.948 0 Td [( dev)13(elopmental anomalies, duplication of the colon)]TJ /T1_2 1 Tf 0.01 Tc 0.018 Tw -4.948 -1.909 Td [(C)19(ONFL)-33(ICT)5( OF)5( INTE)25(REST)62(:)]TJ /T1_0 1 Tf 0 Tc 0.023 Tw 9.871 0 Td [( The authors declare no conf)-22(lict of interest)]TJ /T1_2 1 Tf 0.037 Tc 0.037 Tw -9.871 -2.617 Td [(F)3.2(O)-4.6(R)8.7( )0.5(C)-17.5(I)-15.5(T)45.4(A)37.5(T)-24.5(I)-1.3(ON:)]TJ /T1_3 1 Tf 0.023 Tc 0.046 Tw 6.481 0 Td [( )0.5(C)-15.9(h)-7(u)-21.9(s)-19.1(o)-10.3(v)-28.4(a)]TJ /Span<>> BDC ( )Tj EMC 4.167 0 Td [(K)-27(.)-23.9(A)-23(.)-23.5(, )0.5(B)-14.9(o)-18.6(g)-12.3(d)-9.3(a)-7.6(n)-11.9(o)-10.3(v)]TJ /Span<>> BDC ( )Tj EMC 6.906 0 Td [(A)-23(.)40.6(V)39.7(.)-23.5(, )0.5(S)-3.2(t)-36.8(a)-10.2(r)-30.8(k)-3.7(o)-10.3(v)]TJ /Span<>> BDC ( )Tj EMC 5.756 0 Td [(I)-10.3(.L)-29.5(. )0.5(T)45.8(u)-13.5(b)-15.9(u)-8.4(l)-37.8(a)-10.2(r )0.5(d)-8.9(u)-6.2(p)-20.1(l)-16.7(i)-5(c)-21.5(a)-18.2(t)-46.2(i)-6.8(o)-9.2(n )0.5(o)-12.1(f )0.5(t)-26.1(h)-15.1(e )0.5(s)-26.1(i)-6.8(g)-8.8(m)-12.4(o)-12.5(i)-8.8(d )0.5(c)-6.5(o)-15.6(l)-20.9(o)-9.2(n)4.9(: )0.5(c)-14.4(l)-16.7(i)-3.2(n)-14(i)-5(c)-21.5(a)-11.4(l )0.5(c)-21.5(a)-26.6(s)-22.9(e)-6.9(. )]TJ /T1_0 1 Tf 0.033 Tc -0.033 Tw 26.382 0 Td [(K)13.9(ol)3.6(op)2.4(r)3.1(o)3.4(k)-19.2(t)2.2(ol)3.6(o)-3.3(g)-13.2(i)6.7(a)5.8(.)]TJ /T1_3 1 Tf 0 Tc 0 Tw 6.996 0 Td ( )Tj 0.023 Tc 0.024 Tw -56.693 -1.2 Td [(2)-8.9(0)-3.8(2)8.8(4)10.2(;)9.8(2)-10.3(3)6(\()37.7(1)44.3(\))14.5(:)20.9(1)-7.9(3)-3.8(6)-25.9(\226)50.8(1)12.5(4)40.1(1)4.2(. \()-0.9(i)-3.2(n R)-6.5(u)-21.9(s)-22.3(s)-15.5(.)43.2(\))10.4(. h)-17.2(t)-49.4(t)-29.3(p)-18.7(s)-8.1(:)2(/)84.7(/)36.4(d)-11.1(o)-12.5(i.)2.7(o)-11.8(r)-16.7(g)-22.8(/)11.2(1)14(0)6.5(.)-5.6(3)7.9(3)-15.9(8)1.3(7)4.6(8/)7.9(2)-8.9(0)9.2(7)-1.9(3)-13.2(-)41.2(7)10.6(5)0.5(5)-9(6)-26.7(-)9.8(2)-8.9(0)-3.9(2)8.8(4)-28.5(-)9.7(2)-10.3(3)-13.3(-)55.1(1)26.9(-)55.1(1)-7.9(3)-3.8(6)-26.7(-)55.1(1)12.5(4)40.1(1)]TJ /T1_2 1 Tf 0.01 Tc 0.069 Tw 0.005 -2.617 Td [(\026\020\021\033\030)5( \020\036\017)5( \013\033\021\033\013\023\030\037\023:)]TJ /T1_0 1 Tf 0 Tc 0.074 Tw 10.679 0 Td ( \224\205\t\n\027\026 \222\t\031\021\025\002 \201\021\030\032\031\031\027\ \021\026, \205\023.)Tj /Span<>> BDC ( )Tj EMC (\212\n\030\n\021\025\024\n\027\026\002, 6-169, \036\013\026\024\031\032\025\ \021\005\205\032\202, 620073, \212\n\t\t\025\002; \024\031\023.: +7 \(92\ 2\) 101-52-90; )Tj 0.023 Tw -10.684 -1.2 Td (e-mail: ksenia.tchusova)Tj /T1_2 1 Tf 0.01 Tc 0.033 Tw 0.005 -1.2 Td [(ADDRESS)4.9( F)13(OR)5( C)19(ORRESPONDEN)23(CE:)]TJ /T1_0 1 Tf 0 Tc 0.038 Tw 14.081 0 Td [( Ksenia Andreevna Chusov)16(a, R)19(odonitov)16.1(a st., 6-169, Y)49(ek)11(ater)-37(inburg, 620073, R)22(ussia; tel.: +7 \(922\) 101-52-90; )]TJ 0.023 Tw -14.086 -1.2 Td [(e-mail: k)-23(senia.tchusov)16.1(a)]TJ ET 1 0.68 0 0.12 k /GS0 gs q 1 0 0 1 70.8661 586.1533 cm 0 0 m 0 0 l 0 -11.339 l 42.52 -11.339 l 42.52 0 l h f Q BT 0 0 0 0 k /T1_2 1 Tf 0 Tw 9 0 0 9 76.0071 577.226 Tm (\021\033\r\035\f\033)Tj ET 1 0.68 0 0.12 k q 1 0 0 1 70.8661 250.0605 cm 0 0 m 0 0 l 0 -11.339 l 42.52 -11.339 l 42.52 0 l h f Q BT 0 0 0 0 k /T1_2 1 Tf 9 0 0 9 73.5728 241.1333 Tm (ABSTRACT)Tj ET q 0 0 566.929 793.701 re W n BT 1 0.68 0 0.12 k /T1_4 1 Tf 0.01 Tc 0.018 Tw 14 0 0 14 70.936 837.3533 Tm [(\212\b\006\t\006\223\207\017\212\006\207)5( \t\037\210)21.1(\b\204\216\207\t\006\224)]TJ /T1_1 1 Tf 0 -1.605 TD [(C)10(A)20(SE)5( REPORT)]TJ ET Q BT 1 0.68 0 0.12 k /T1_1 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\037\035\030\213\030\003\t\021\037\030\t \213\b\214\035\200)15(\255\t\213\030\027)]TJ 54.711 0 Td [(C)10(A)20(SE REPORT)]TJ -54.711 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 23, \023\0221)69(, 202)69(4)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 23, \023\0221)69(, 202)69(4)]TJ /T1_5 1 Tf 25 0 0 25 20.7651 56.0378 Tm (136)Tj ET q 0 g 0 G 0 j 0 J /Fm1 Do Q 0 0 0 0 k 396.85 725.67 59.155 11.338 re f /PlacedPDF /MC0 BDC q 397.481 736.808 m 397.242 736.808 397.049 736.616 397.049 736.376 c 397.049 736.376 l 397.049 726.285 l 397.049 726.045 397.242 725.853 397.481 725.853 c 397.481 725.853 l 455.382 725.853 l 455.62 725.853 455.815 726.045 455.815 726.285 c 455.815 726.285 l 455.815 736.376 l 455.815 736.616 455.62 736.808 455.382 736.808 c 455.382 736.808 l h W n q 0 g -0.0000005 -10.9560913 -10.9560913 0.0000005 426.4320445 736.8086309 cm BX /Sh0 sh EX Q Q q 396.85 725.67 59.155 11.337 re W n 0 0 0 0.84 k q 1 0 0 1 413.5634 732.4249 cm 0 0 m -0.025 0.1 -0.063 0.196 -0.112 0.287 c -0.157 0.374 -0.218 0.451 -0.292 0.515 c -0.37 0.582 -0.46 0.632 -0.558 0.664 c -0.669 0.701 -0.786 0.719 -0.903 0.717 c -1.076 0.722 -1.247 0.681 -1.4 0.6 c -1.536 0.526 -1.652 0.42 -1.74 0.292 c -1.83 0.158 -1.895 0.008 -1.934 -0.149 c -2.018 -0.48 -2.018 -0.827 -1.934 -1.158 c -1.896 -1.316 -1.83 -1.466 -1.74 -1.602 c -1.653 -1.731 -1.536 -1.837 -1.4 -1.912 c -1.247 -1.993 -1.076 -2.033 -0.903 -2.029 c -0.774 -2.032 -0.647 -2.006 -0.528 -1.955 c -0.427 -1.906 -0.337 -1.837 -0.263 -1.753 c -0.185 -1.665 -0.124 -1.563 -0.082 -1.453 c -0.034 -1.338 0 -1.218 0.019 -1.094 c 0.635 -1.094 l 0.624 -1.297 0.578 -1.497 0.497 -1.684 c 0.421 -1.857 0.312 -2.015 0.175 -2.146 c 0.039 -2.277 -0.123 -2.379 -0.3 -2.446 c -0.492 -2.519 -0.695 -2.555 -0.9 -2.552 c -1.15 -2.557 -1.397 -2.506 -1.625 -2.404 c -1.829 -2.307 -2.01 -2.169 -2.157 -1.997 c -2.308 -1.821 -2.423 -1.617 -2.497 -1.397 c -2.655 -0.924 -2.655 -0.412 -2.497 0.061 c -2.423 0.281 -2.307 0.485 -2.157 0.661 c -2.01 0.833 -1.829 0.973 -1.625 1.07 c -1.398 1.174 -1.15 1.226 -0.9 1.222 c -0.707 1.223 -0.515 1.196 -0.329 1.14 c -0.159 1.088 0.001 1.006 0.144 0.898 c 0.278 0.793 0.39 0.662 0.473 0.513 c 0.562 0.349 0.615 0.167 0.629 -0.019 c 0 -0.019 l 0 0 l f Q q 1 0 0 1 414.6923 733.5723 cm 0 0 m 0.584 0 l 0.584 -1.328 l 0.662 -1.204 0.771 -1.103 0.9 -1.033 c 1.046 -0.951 1.213 -0.91 1.381 -0.914 c 1.627 -0.9 1.869 -0.979 2.058 -1.137 c 2.234 -1.312 2.325 -1.556 2.305 -1.803 c 2.305 -3.596 l 1.716 -3.596 l 1.716 -1.976 l 1.724 -1.817 1.678 -1.66 1.585 -1.53 c 1.486 -1.43 1.347 -1.379 1.206 -1.392 c 1.114 -1.39 1.024 -1.408 0.94 -1.445 c 0.865 -1.479 0.798 -1.529 0.744 -1.591 c 0.687 -1.656 0.645 -1.73 0.616 -1.812 c 0.586 -1.896 0.571 -1.986 0.571 -2.077 c 0.571 -3.615 l 0 -3.615 l 0 0 l f Q q 1 0 0 1 418.0385 731.1235 cm 0 0 m 0 -0.099 0.014 -0.198 0.043 -0.292 c 0.069 -0.382 0.112 -0.466 0.17 -0.54 c 0.229 -0.611 0.304 -0.669 0.388 -0.709 c 0.486 -0.754 0.594 -0.776 0.702 -0.773 c 0.845 -0.78 0.987 -0.742 1.108 -0.664 c 1.217 -0.582 1.296 -0.468 1.336 -0.337 c 1.881 -0.337 l 1.827 -0.603 1.675 -0.838 1.456 -0.996 c 1.35 -1.073 1.231 -1.131 1.105 -1.169 c 0.971 -1.208 0.831 -1.229 0.691 -1.227 c 0.509 -1.227 0.328 -1.191 0.16 -1.121 c 0.007 -1.063 -0.13 -0.972 -0.244 -0.855 c -0.356 -0.73 -0.44 -0.583 -0.491 -0.422 c -0.548 -0.243 -0.576 -0.056 -0.574 0.133 c -0.575 0.313 -0.545 0.493 -0.486 0.664 c -0.426 0.826 -0.335 0.974 -0.22 1.102 c 0.004 1.375 0.338 1.534 0.691 1.535 c 0.883 1.539 1.072 1.495 1.243 1.408 c 1.402 1.326 1.541 1.209 1.649 1.067 c 1.759 0.922 1.838 0.757 1.883 0.582 c 1.932 0.396 1.945 0.203 1.92 0.013 c 0 0.013 l 0 0 l 1.342 0.377 m 1.335 0.468 1.315 0.557 1.283 0.643 c 1.253 0.724 1.209 0.798 1.153 0.863 c 1.097 0.922 1.03 0.97 0.957 1.004 c 0.874 1.043 0.783 1.063 0.691 1.062 c 0.6 1.062 0.509 1.044 0.425 1.009 c 0.345 0.976 0.273 0.926 0.213 0.863 c 0.153 0.799 0.105 0.724 0.072 0.643 c 0.037 0.559 0.017 0.468 0.014 0.377 c 1.355 0.377 l h f Q q 1 0 0 1 422.1581 731.7051 cm 0 0 m -0.012 0.144 -0.082 0.276 -0.194 0.366 c -0.31 0.452 -0.451 0.495 -0.595 0.489 c -0.675 0.488 -0.755 0.476 -0.831 0.452 c -0.918 0.424 -0.998 0.375 -1.062 0.311 c -1.142 0.229 -1.202 0.131 -1.24 0.024 c -1.29 -0.132 -1.312 -0.296 -1.304 -0.459 c -1.304 -0.569 -1.292 -0.677 -1.267 -0.784 c -1.244 -0.885 -1.202 -0.983 -1.145 -1.07 c -1.09 -1.154 -1.016 -1.224 -0.93 -1.275 c -0.833 -1.33 -0.722 -1.356 -0.611 -1.352 c -0.457 -1.357 -0.307 -1.301 -0.194 -1.195 c -0.078 -1.077 -0.005 -0.922 0.011 -0.757 c 0.587 -0.757 l 0.556 -1.055 0.419 -1.332 0.202 -1.538 c -0.022 -1.721 -0.306 -1.815 -0.595 -1.803 c -0.777 -1.806 -0.958 -1.771 -1.126 -1.7 c -1.293 -1.642 -1.445 -1.547 -1.57 -1.421 c -1.68 -1.297 -1.763 -1.151 -1.814 -0.993 c -1.87 -0.822 -1.898 -0.643 -1.896 -0.462 c -1.898 -0.276 -1.871 -0.091 -1.817 0.087 c -1.766 0.252 -1.682 0.405 -1.57 0.537 c -1.459 0.664 -1.323 0.766 -1.168 0.834 c -0.991 0.914 -0.798 0.955 -0.603 0.954 c -0.457 0.954 -0.311 0.935 -0.17 0.895 c -0.039 0.858 0.084 0.799 0.194 0.72 c 0.302 0.643 0.393 0.543 0.459 0.428 c 0.531 0.298 0.572 0.155 0.582 0.008 c 0 0.008 l 0 0 l f Q q 1 0 0 1 423.2177 733.5723 cm 0 0 m 0.577 0 l 0.577 -2.048 l 1.615 -0.985 l 2.322 -0.985 l 1.323 -1.944 l 2.417 -3.604 l 1.716 -3.604 l 0.919 -2.337 l 0.577 -2.669 l 0.577 -3.604 l 0 -3.604 l h f Q q 1 0 0 1 427.0585 732.5762 cm 0 0 m 0.436 0 l 0.436 0.218 l 0.429 0.352 0.448 0.486 0.488 0.614 c 0.521 0.705 0.577 0.786 0.651 0.85 c 0.717 0.905 0.795 0.943 0.879 0.961 c 0.966 0.979 1.056 0.988 1.145 0.988 c 1.28 0.993 1.416 0.981 1.548 0.954 c 1.548 0.505 l 1.509 0.516 1.469 0.523 1.429 0.528 c 1.379 0.532 1.33 0.532 1.28 0.528 c 1.209 0.53 1.14 0.511 1.081 0.473 c 1.019 0.419 0.987 0.337 0.999 0.255 c 0.999 -0.011 l 1.498 -0.011 l 1.498 -0.441 l 1.009 -0.441 l 1.009 -2.622 l 0.436 -2.622 l 0.436 -0.428 l 0.005 -0.428 l 0.005 0 l 0 0 l f Q q 1 0 0 1 430.1 729.8965 cm 0 0 m -0.191 -0.003 -0.381 0.032 -0.559 0.104 c -0.715 0.167 -0.856 0.264 -0.972 0.388 c -1.091 0.512 -1.181 0.659 -1.238 0.82 c -1.356 1.18 -1.356 1.567 -1.238 1.925 c -1.181 2.087 -1.091 2.234 -0.972 2.358 c -0.856 2.481 -0.715 2.578 -0.559 2.643 c -0.199 2.78 0.198 2.78 0.558 2.643 c 0.714 2.578 0.855 2.481 0.972 2.358 c 1.09 2.234 1.181 2.087 1.237 1.925 c 1.355 1.567 1.355 1.18 1.237 0.82 c 1.181 0.659 1.09 0.512 0.972 0.388 c 0.855 0.266 0.713 0.169 0.558 0.106 c 0.38 0.034 0.191 -0.002 0 0 c 0 0.454 m 0.115 0.451 0.23 0.479 0.332 0.534 c 0.424 0.586 0.502 0.659 0.562 0.746 c 0.624 0.836 0.669 0.936 0.695 1.041 c 0.752 1.26 0.752 1.491 0.695 1.71 c 0.669 1.816 0.625 1.916 0.562 2.005 c 0.502 2.091 0.423 2.163 0.332 2.215 c 0.123 2.323 -0.126 2.323 -0.335 2.215 c -0.427 2.163 -0.505 2.091 -0.566 2.005 c -0.628 1.916 -0.673 1.816 -0.699 1.71 c -0.756 1.491 -0.756 1.26 -0.699 1.041 c -0.672 0.936 -0.627 0.836 -0.566 0.746 c -0.506 0.659 -0.427 0.586 -0.335 0.534 c -0.232 0.478 -0.117 0.451 0 0.454 c f Q q 1 0 0 1 431.8979 732.5762 cm 0 0 m 0.531 0 l 0.531 -0.505 l 0.55 -0.43 0.583 -0.359 0.629 -0.297 c 0.681 -0.229 0.74 -0.167 0.807 -0.114 c 0.877 -0.059 0.956 -0.014 1.039 0.019 c 1.123 0.053 1.213 0.07 1.304 0.069 c 1.52 0.069 l 1.52 -0.486 l 1.395 -0.467 l 1.269 -0.467 l 1.178 -0.468 1.087 -0.488 1.004 -0.526 c 0.917 -0.565 0.839 -0.625 0.778 -0.699 c 0.716 -0.783 0.669 -0.878 0.643 -0.98 c 0.604 -1.104 0.584 -1.233 0.586 -1.362 c 0.586 -2.603 l 0.01 -2.603 l 0.01 0 l 0 0 l f Q q 1 0 0 1 437.3666 729.9683 cm 0 0 m -0.577 0 l -0.577 0.364 l -0.649 0.23 -0.759 0.121 -0.893 0.047 c -1.022 -0.029 -1.169 -0.07 -1.32 -0.072 c -1.595 -0.095 -1.866 0.002 -2.064 0.194 c -2.234 0.413 -2.316 0.687 -2.295 0.964 c -2.295 2.608 l -1.719 2.608 l -1.719 1.014 l -1.735 0.843 -1.689 0.67 -1.588 0.531 c -1.492 0.433 -1.357 0.382 -1.219 0.39 c -1.116 0.387 -1.012 0.406 -0.917 0.446 c -0.84 0.479 -0.772 0.531 -0.72 0.595 c -0.667 0.661 -0.63 0.738 -0.611 0.82 c -0.588 0.911 -0.577 1.003 -0.577 1.097 c -0.577 2.611 l 0 2.611 l 0 0 l f Q q 1 0 0 1 437.9877 732.5762 cm 0 0 m 0.545 0 l 0.545 -0.353 l 0.617 -0.209 0.736 -0.094 0.882 -0.026 c 1.03 0.04 1.19 0.073 1.352 0.072 c 1.535 0.075 1.717 0.038 1.883 -0.037 c 2.031 -0.106 2.161 -0.208 2.263 -0.334 c 2.366 -0.465 2.442 -0.615 2.489 -0.775 c 2.54 -0.948 2.566 -1.127 2.566 -1.307 c 2.566 -1.479 2.542 -1.651 2.497 -1.817 c 2.455 -1.973 2.385 -2.121 2.29 -2.252 c 2.099 -2.522 1.789 -2.682 1.458 -2.68 c 1.369 -2.681 1.28 -2.674 1.193 -2.659 c 1.11 -2.644 1.028 -2.618 0.951 -2.584 c 0.875 -2.552 0.802 -2.509 0.736 -2.457 c 0.671 -2.406 0.615 -2.343 0.571 -2.273 c 0.571 -3.575 l -0.005 -3.575 l -0.005 0 l 0 0 l 2.008 -1.307 m 2.008 -1.191 1.993 -1.076 1.963 -0.964 c 1.936 -0.859 1.89 -0.759 1.828 -0.669 c 1.768 -0.584 1.69 -0.514 1.599 -0.462 c 1.503 -0.409 1.395 -0.382 1.286 -0.385 c 1.072 -0.372 0.867 -0.467 0.738 -0.638 c 0.607 -0.836 0.543 -1.072 0.555 -1.31 c 0.554 -1.433 0.57 -1.557 0.603 -1.676 c 0.631 -1.781 0.68 -1.879 0.747 -1.965 c 0.809 -2.044 0.886 -2.109 0.975 -2.157 c 1.071 -2.206 1.178 -2.23 1.286 -2.229 c 1.401 -2.232 1.517 -2.205 1.618 -2.148 c 1.708 -2.096 1.785 -2.025 1.843 -1.939 c 1.903 -1.85 1.945 -1.751 1.968 -1.646 c 1.995 -1.535 2.008 -1.421 2.008 -1.307 c f Q q 1 0 0 1 443.5127 729.9683 cm 0 0 m -0.545 0 l -0.545 0.353 l -0.616 0.211 -0.734 0.099 -0.879 0.034 c -1.027 -0.031 -1.187 -0.065 -1.349 -0.064 c -1.532 -0.067 -1.714 -0.03 -1.88 0.045 c -2.028 0.113 -2.158 0.214 -2.26 0.34 c -2.364 0.47 -2.441 0.62 -2.486 0.781 c -2.538 0.958 -2.564 1.143 -2.563 1.328 c -2.568 1.536 -2.536 1.742 -2.468 1.938 c -2.41 2.097 -2.319 2.242 -2.202 2.364 c -2.101 2.471 -1.977 2.555 -1.838 2.608 c -1.705 2.659 -1.563 2.685 -1.421 2.685 c -1.338 2.685 -1.256 2.678 -1.174 2.664 c -1.091 2.648 -1.01 2.624 -0.932 2.589 c -0.855 2.556 -0.783 2.514 -0.717 2.462 c -0.652 2.411 -0.597 2.349 -0.553 2.279 c -0.553 3.606 l 0.024 3.606 l 0.024 0 l 0 0 l -2.008 1.277 m -2.009 1.166 -1.994 1.056 -1.965 0.948 c -1.939 0.845 -1.896 0.748 -1.835 0.661 c -1.777 0.578 -1.699 0.508 -1.61 0.459 c -1.404 0.355 -1.162 0.355 -0.956 0.459 c -0.866 0.512 -0.789 0.585 -0.73 0.671 c -0.671 0.762 -0.626 0.862 -0.6 0.966 c -0.572 1.076 -0.558 1.188 -0.558 1.301 c -0.543 1.542 -0.612 1.781 -0.751 1.979 c -0.88 2.14 -1.078 2.229 -1.283 2.22 c -1.402 2.224 -1.52 2.196 -1.623 2.138 c -1.714 2.083 -1.793 2.009 -1.852 1.92 c -1.911 1.828 -1.954 1.725 -1.977 1.617 c -1.999 1.505 -2.01 1.392 -2.008 1.277 c f Q q 1 0 0 1 446.3252 730.5499 cm 0 0 m -0.004 -0.052 0.005 -0.104 0.026 -0.151 c 0.052 -0.185 0.094 -0.202 0.136 -0.197 c 0.197 -0.197 l 0.223 -0.2 0.25 -0.2 0.276 -0.197 c 0.276 -0.595 l 0.199 -0.619 l 0.101 -0.64 l 0 -0.656 l -0.085 -0.656 l -0.187 -0.66 -0.288 -0.635 -0.377 -0.584 c -0.461 -0.528 -0.516 -0.437 -0.528 -0.337 c -0.648 -0.451 -0.792 -0.534 -0.951 -0.579 c -1.106 -0.628 -1.269 -0.654 -1.432 -0.656 c -1.546 -0.657 -1.659 -0.641 -1.769 -0.608 c -1.872 -0.579 -1.967 -0.531 -2.053 -0.468 c -2.136 -0.405 -2.203 -0.324 -2.25 -0.231 c -2.3 -0.127 -2.326 -0.012 -2.324 0.104 c -2.33 0.24 -2.299 0.375 -2.236 0.497 c -2.181 0.594 -2.101 0.675 -2.005 0.733 c -1.905 0.791 -1.795 0.833 -1.681 0.855 c -1.562 0.88 -1.442 0.899 -1.32 0.914 c -1.222 0.933 -1.123 0.947 -1.022 0.956 c -0.938 0.963 -0.855 0.977 -0.773 0.999 c -0.708 1.014 -0.649 1.046 -0.6 1.092 c -0.556 1.144 -0.533 1.211 -0.536 1.28 c -0.534 1.344 -0.553 1.408 -0.59 1.46 c -0.624 1.507 -0.668 1.544 -0.72 1.569 c -0.775 1.596 -0.834 1.613 -0.895 1.62 c -0.955 1.624 -1.016 1.624 -1.076 1.62 c -1.215 1.625 -1.354 1.591 -1.474 1.519 c -1.581 1.45 -1.647 1.333 -1.652 1.206 c -2.231 1.206 l -2.227 1.354 -2.185 1.498 -2.108 1.625 c -2.041 1.733 -1.951 1.824 -1.843 1.891 c -1.729 1.96 -1.603 2.007 -1.472 2.032 c -1.329 2.072 -1.183 2.098 -1.036 2.109 c -0.908 2.109 -0.781 2.096 -0.656 2.069 c -0.538 2.044 -0.425 2 -0.321 1.939 c -0.225 1.88 -0.143 1.8 -0.083 1.705 c -0.02 1.599 0.012 1.478 0.008 1.354 c 0.008 0.013 l 0 0 l -0.576 0.728 m -0.674 0.667 -0.785 0.631 -0.9 0.624 c -1.028 0.612 -1.155 0.594 -1.283 0.571 c -1.343 0.561 -1.402 0.547 -1.46 0.528 c -1.515 0.511 -1.566 0.485 -1.612 0.451 c -1.657 0.419 -1.692 0.376 -1.716 0.327 c -1.742 0.267 -1.755 0.203 -1.753 0.138 c -1.755 0.079 -1.735 0.021 -1.697 -0.024 c -1.661 -0.067 -1.615 -0.103 -1.564 -0.127 c -1.509 -0.154 -1.451 -0.171 -1.392 -0.181 c -1.335 -0.19 -1.278 -0.196 -1.222 -0.197 c -1.152 -0.196 -1.083 -0.188 -1.015 -0.173 c -0.94 -0.156 -0.87 -0.127 -0.805 -0.088 c -0.74 -0.048 -0.684 0.004 -0.64 0.066 c -0.594 0.134 -0.571 0.215 -0.574 0.297 c -0.574 0.725 l h f Q q 1 0 0 1 446.6836 732.5762 cm 0 0 m 0.434 0 l 0.434 0.784 l 0.996 0.784 l 0.996 0 l 1.527 0 l 1.527 -0.43 l 0.996 -0.43 l 0.996 -1.822 l 0.993 -1.874 0.993 -1.927 0.996 -1.979 c 1 -2.018 1.011 -2.056 1.031 -2.09 c 1.05 -2.122 1.079 -2.146 1.113 -2.159 c 1.162 -2.177 1.213 -2.185 1.265 -2.183 c 1.387 -2.183 l 1.428 -2.181 1.469 -2.175 1.509 -2.165 c 1.509 -2.608 l 1.323 -2.629 l 1.261 -2.633 1.199 -2.633 1.137 -2.629 c 1.013 -2.633 0.89 -2.619 0.771 -2.587 c 0.688 -2.564 0.613 -2.52 0.553 -2.459 c 0.499 -2.4 0.462 -2.328 0.446 -2.25 c 0.427 -2.155 0.416 -2.059 0.415 -1.963 c 0.415 -0.428 l -0.019 -0.428 l -0.019 0 l 0 0 l f Q q 1 0 0 1 449.0742 731.1235 cm 0 0 m 0 -0.099 0.014 -0.198 0.042 -0.292 c 0.068 -0.382 0.112 -0.466 0.17 -0.54 c 0.229 -0.611 0.303 -0.669 0.388 -0.709 c 0.486 -0.754 0.593 -0.776 0.701 -0.773 c 0.845 -0.78 0.987 -0.742 1.107 -0.664 c 1.216 -0.582 1.296 -0.468 1.336 -0.337 c 1.88 -0.337 l 1.827 -0.603 1.674 -0.838 1.456 -0.996 c 1.349 -1.073 1.231 -1.131 1.105 -1.169 c 0.973 -1.208 0.836 -1.228 0.699 -1.227 c 0.512 -1.23 0.327 -1.196 0.154 -1.126 c 0.003 -1.066 -0.133 -0.973 -0.244 -0.855 c -0.356 -0.73 -0.44 -0.583 -0.491 -0.422 c -0.548 -0.243 -0.576 -0.056 -0.574 0.133 c -0.575 0.313 -0.546 0.493 -0.486 0.664 c -0.426 0.826 -0.336 0.974 -0.221 1.102 c 0.002 1.374 0.334 1.532 0.685 1.535 c 0.877 1.539 1.067 1.495 1.238 1.408 c 1.396 1.326 1.535 1.209 1.644 1.067 c 1.753 0.922 1.833 0.757 1.878 0.582 c 1.927 0.396 1.939 0.203 1.915 0.013 c -0.002 0.013 l 0 0 l 1.341 0.377 m 1.335 0.468 1.315 0.557 1.283 0.643 c 1.253 0.724 1.209 0.798 1.153 0.863 c 1.096 0.926 1.027 0.978 0.951 1.014 c 0.868 1.054 0.777 1.074 0.685 1.073 c 0.594 1.073 0.504 1.055 0.419 1.02 c 0.339 0.986 0.267 0.937 0.207 0.874 c 0.147 0.81 0.099 0.735 0.066 0.653 c 0.031 0.569 0.011 0.479 0.008 0.388 c 1.349 0.388 l h f Q q 1 0 0 1 451.8657 730.7994 cm 0 0 m 0.002 -0.142 0.073 -0.274 0.191 -0.353 c 0.312 -0.423 0.45 -0.458 0.59 -0.454 c 0.651 -0.458 0.711 -0.458 0.773 -0.454 c 0.839 -0.447 0.904 -0.43 0.967 -0.406 c 1.024 -0.385 1.075 -0.349 1.116 -0.303 c 1.155 -0.252 1.174 -0.189 1.168 -0.125 c 1.166 -0.057 1.138 0.008 1.089 0.056 c 1.033 0.107 0.967 0.146 0.895 0.17 c 0.809 0.201 0.72 0.226 0.629 0.245 c 0.329 0.33 l 0.224 0.352 0.121 0.38 0.019 0.415 c -0.076 0.446 -0.166 0.491 -0.247 0.55 c -0.327 0.608 -0.391 0.683 -0.436 0.771 c -0.486 0.873 -0.511 0.986 -0.507 1.1 c -0.512 1.226 -0.475 1.351 -0.404 1.456 c -0.333 1.551 -0.243 1.63 -0.138 1.687 c -0.028 1.747 0.092 1.788 0.215 1.809 c 0.337 1.832 0.462 1.843 0.587 1.843 c 0.716 1.844 0.845 1.83 0.972 1.801 c 1.09 1.774 1.202 1.727 1.304 1.663 c 1.404 1.598 1.488 1.513 1.551 1.413 c 1.621 1.3 1.663 1.173 1.676 1.041 c 1.076 1.041 l 1.059 1.155 0.989 1.253 0.887 1.307 c 0.78 1.355 0.665 1.38 0.547 1.378 c 0.5 1.381 0.452 1.381 0.403 1.378 c 0.35 1.373 0.298 1.36 0.247 1.341 c 0.2 1.325 0.157 1.297 0.122 1.262 c 0.087 1.224 0.069 1.174 0.071 1.124 c 0.069 1.058 0.096 0.995 0.146 0.951 c 0.202 0.903 0.267 0.866 0.337 0.842 c 0.424 0.811 0.512 0.786 0.603 0.768 c 0.917 0.701 l 1.021 0.678 1.124 0.65 1.224 0.616 c 1.319 0.584 1.409 0.539 1.49 0.481 c 1.662 0.359 1.762 0.16 1.755 -0.05 c 1.76 -0.189 1.723 -0.326 1.649 -0.443 c 1.582 -0.551 1.491 -0.642 1.384 -0.709 c 1.267 -0.778 1.14 -0.827 1.007 -0.855 c 0.873 -0.885 0.735 -0.9 0.598 -0.9 c 0.443 -0.902 0.29 -0.883 0.141 -0.845 c 0.01 -0.812 -0.114 -0.753 -0.223 -0.674 c -0.324 -0.601 -0.407 -0.504 -0.465 -0.393 c -0.527 -0.269 -0.559 -0.131 -0.558 0.008 c 0.019 0.008 l 0 0 l f Q 0.146 0.941 0.992 0.044 k q 1 0 0 1 401.2527 729.3892 cm 0 0 m 3.612 2.406 l 3.612 5.296 l 0 5.296 l h f Q 0 0.889 0.676 0 k q 1 0 0 1 404.865 729.3892 cm 0 0 m -3.612 2.406 l -3.612 5.296 l 0 5.296 l h f Q 0.694 0.076 0.209 0 k q 1 0 0 1 403.0589 735.3145 cm 0 0 m -2.2 0 -3.984 -1.784 -3.984 -3.984 c -3.984 -6.184 -2.2 -7.968 0 -7.968 c 2.2 -7.968 3.984 -6.184 3.984 -3.984 c 3.984 -1.784 2.2 0 0 0 c 0 -6.993 m -1.662 -6.993 -3.009 -5.646 -3.009 -3.984 c -3.009 -2.322 -1.662 -0.975 0 -0.975 c 1.662 -0.975 3.009 -2.322 3.009 -3.984 c 3.009 -5.646 1.662 -6.993 0 -6.993 c f Q 0 0.235 0.86 0 k q 1 0 0 1 405.2601 729.2803 cm 0 0 m -1.118 -1.208 -3.015 -1.281 -4.237 -0.159 c -5.159 0.688 -5.459 2.005 -4.999 3.156 c -5.833 3.687 l -6.736 1.681 -5.843 -0.679 -3.836 -1.582 c -2.218 -2.311 -0.312 -1.881 0.836 -0.528 c 0 0 l f Q 0 0 0 0.6 k q 1 0 0 1 397.4813 736.8087 cm 0 0 m -0.238 0 -0.432 -0.193 -0.432 -0.432 c -0.432 -10.524 l -0.432 -10.763 -0.238 -10.956 0 -10.956 c 57.901 -10.956 l 58.139 -10.956 58.333 -10.763 58.333 -10.524 c 58.333 -0.432 l 58.333 -0.193 58.139 0 57.901 0 c h 57.901 -11.155 m 0 -11.155 l -0.348 -11.155 -0.631 -10.872 -0.631 -10.524 c -0.631 -0.432 l -0.631 -0.084 -0.348 0.199 0 0.199 c 57.901 0.199 l 58.249 0.199 58.532 -0.084 58.532 -0.432 c 58.532 -10.524 l 58.532 -10.872 58.249 -11.155 57.901 -11.155 c f Q EMC Q endstream endobj 967 0 obj <> endobj 989 0 obj <>stream Adobe Illustrator CS6 (Windows) 2021-04-12T11:45:36+05:00 2021-06-02T10:28:09+05:00 2021-06-02T10:28:09+05:00 1 False False 20.868494 3.999928 Millimeters Cyan Magenta Yellow Black Default Swatch Group 0 C=0 M=24 Y=86 K=0 PROCESS 100.000000 CMYK 0.000000 23.504999 86.022697 0.000000 C=69 M=8 Y=21 K=0 PROCESS 100.000000 CMYK 69.369003 7.635600 20.892700 0.000000 C=0 M=89 Y=68 K=0 PROCESS 100.000000 CMYK 0.000000 88.946404 67.623398 0.000000 C=15 M=94 Y=99 K=4 PROCESS 100.000000 CMYK 14.578501 94.070297 99.160698 4.416000 C=0 M=0 Y=0 K=84 PROCESS 100.000000 CMYK 0.000000 0.000000 0.000000 84.000000 C=0 M=0 Y=0 K=35 PROCESS 100.000000 CMYK 0.000000 0.000000 0.000000 35.000000 C=0 M=0 Y=0 K=60 PROCESS 100.000000 CMYK 0.000000 0.000000 0.000000 60.000004 Document application/pdf proof:pdf xmp.did:804244B35A9BEB118A6FC3C256996E2F uuid:08e30110-bdb7-4606-97ca-63fb62cbcecc uuid:21079f76-f6d7-4329-b725-f2fb35af5114 uuid:722f8893-0b3c-4402-87fb-c713f1fa0e26 uuid:21079f76-f6d7-4329-b725-f2fb35af5114 uuid:21079f76-f6d7-4329-b725-f2fb35af5114 proof:pdf saved xmp.iid:804244B35A9BEB118A6FC3C256996E2F 2021-04-12T11:45:42+05:00 Adobe Illustrator CS6 (Windows) / endstream endobj 988 0 obj <>/Border[0 0 0]/H/N/Rect[394.85 739.008 458.005 723.67]/Subtype/Link/Type/Annot>> endobj 990 0 obj <> endobj 752 0 obj <>/Font<>/ProcSet[/PDF/Text/ImageC]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 753 0 obj <>/Font<>/ProcSet[/PDF/Text/ImageC]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 754 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 755 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 756 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1001 0 obj [1003 0 R 1004 0 R 1005 0 R 1006 0 R 1007 0 R 1008 0 R 1009 0 R 1010 0 R 1011 0 R] endobj 1002 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\213\025\r\020\203 \006\221\025\006\025\f \221\007\013\006)-10(\026\220\017\016\006\n)10(\025\202)10(\025 \222\013\n\002\020\026\220\205 \002\013\001\016\r\025\202)10(\025 )]TJ 0 -1 TD [(\201\016\225\016\n)-10(\026)11(\013 \221\025\006)-10(\007\016 \220\006\006\016\017\016\001\220\205 \221\220\007\025\001\220\201\ \013\007\216\001\025\203 \n\220\006)-10(\026\020)]TJ 33.357 1 Td [(A ne)11(w meth)11(od for w)11(ound defect closur)31(e af)-31(ter pilonidal sinus e)21(x)21.1(cision)]TJ /T1_1 1 Tf 8 0 0 8 42.5197 731.2159 Tm [(medic)-24(ina56070341)]TJ 0 0 0 1 k /GS1 gs 0.014 Tc 0.498 Tw 0 -1.25 TD (9.)Tj /Span<>> BDC 0.823 0 Td ( )Tj EMC 0.514 0 Td [(Z)25.4(o)0.5(l)30.4(o)17.5(tu)0.5(khi)0.5(n)]TJ /Span<>> BDC ( )Tj EMC [(D)0.5(.S.)0.5(, S)0.5(er)-31.5(gi)0.5(jko)]TJ /Span<>> BDC 11.145 0 Td ( )Tj EMC [(S.)0.5(V.)0.5(, K)0.5(r)-31.6(o)-15.6(c)0.5(he)0.5(k)]TJ /Span<>> BDC ( )Tj EMC [(I)0.5(.V.)0.5( S)-15.6(o)0.5(vr)-23.5(em)0.5(en)0.5(nye)14( )]TJ 0 Tc 0.316 Tw -12.482 -1.25 Td [(me)-12(t)17(od)17(y lechenija jepi)-23.9(tel)-31(ial\245no)-16(go kopchikovo)-16(go hod)42(a. )]TJ /T1_2 1 Tf 0 Tw [(T)54(avr)-37(icheski)11.1(j )]TJ 0.017 Tc 0.609 Tw T* [(medik)13.3(o-biologicheski)11.3(j v)13.2(estnik)]TJ /T1_1 1 Tf [(. 2021;24\(1\):80\22688. \(In Russ.\).)17( )]TJ 0 Tc 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.37279/2070-8092-2021-24-1-80-88)Tj 0 0 0 1 k /GS1 gs 0.002 Tc 0.35 Tw -1.847 -1.25 Td (10.)Tj /Span<>> BDC ( )Tj EMC 1.806 0 Td [(Har)-33.4(abe)-12.4(t)]TJ /Span<>> BDC ( )Tj EMC [(E.I., G)19.6(r)-32.4(oshil)-31.4(in)]TJ /Span<>> BDC ( )Tj EMC [(V.S., P)9.6(or)-32.4(ojsk)-16.4(ij)]TJ /Span<>> BDC ( )Tj EMC [(S.V., e)-12.4(t.al. R)12.6(ezul\245t)14.6(a)14.6(t)-10.4(y)2( )]TJ 0 Tc 0.12 Tw -1.806 -1.25 Td [(vnedr)-23.9(enija novo)-15.9(go d)-17(vuhje)-11.9(t)15(apno)-16(go me)-12(t)17(od)42(a lechenijaj epi)-24(tel)-31(ial\245no)-15.9(go )]TJ 0.018 Tc 0.651 Tw T* [(kopchikovo)-16(go hod)42.1(a. )]TJ /T1_2 1 Tf [(V)33(estnik v)13.1(olgog)14(radsk)13.1(ogo gosud)26(arstv)13.1(enno)]TJ 0 Tc 0 Tw (-)Tj 0.008 Tc 0.349 Tw T* [(g)0.5(o)0.6( m)0.5(e)0.6(d)0.5(i)0.6(c)0.5(i)0.6(n)0.5(s)0.6(k)13.5(o)0.5(g)0.6(o)0.5( u)0.6(n)0.5(i)0.6(v)13.5(e)0.5(r)0.6(s)0.5(t)0.6(i)0.5(t)0.6(e)0.5(t)0.6(a)]TJ /T1_1 1 Tf 12.609 0 Td [(.)0.5( 2)0.6(0)0.5(2)0.6(2)0.5(;)0.5(1)0.6(9)0.5(\()0.6(3)0.5(\))0.5(:)0.6(1)0.5(1)0.6(5)0.5(\226)0.5(1)0.6(2)0.5(0)0.6(.)0.5( \()0.6(I)0.5(n)0.5( R)0.6(u)0.5(s)0.6(s)0.5(.)0.6(\))0.5(.)8( )]TJ 0 Tc 0 Tw -12.609 -1.25 Td [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.19163/1994-9480-2022-19-3-115-120)Tj 0 0 0 1 k /GS1 gs 0.037 Tw -1.847 -1.25 Td (11.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Iesalniek)-9.9(s)]TJ /Span<>> BDC ( )Tj EMC (I, Ommer)Tj /Span<>> BDC ( )Tj EMC [(A, P)30(e)-12(ter)-10(sen)]TJ /Span<>> BDC ( )Tj EMC [(S, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Ger)-15.9(man na)15(t)-32(ional guide)]TJ 0 Tw (-)Tj 0.01 Tw -1.796 -1.25 Td [(l)-31(ine )0.6(on )0.5(t)-13(he )0.6(mana)-17(gement )0.6(of )0.5(pil)30(onid)42(al )0.6(disease. )]TJ /T1_2 1 Tf 0 Tw 18.384 0 Td [(Lang)12(enbeck)-22.9(s)]TJ /T1_1 1 Tf ( )Tj /T1_2 1 Tf 0.01 Tw 5.224 0 Td [(Arch )0.6(Surg.)]TJ /T1_1 1 Tf 0 Tw ( )Tj 0.023 Tw -23.608 -1.25 Td [(2016;401\(5\):599\226609. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1007/s00423-016-1463-7)Tj 0 0 0 1 k /GS1 gs -0.007 Tw 29.055 15 Td (12.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(S)15(t)15(auf)-56(fer)]TJ /Span<>> BDC ( )Tj EMC [(VK, L)35(uedi)]TJ /Span<>> BDC ( )Tj EMC [(MM, K)-16(auf)]TJ /Span<>> BDC ( )Tj EMC [(P, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Common sur)-32(gical p)25(r)-32(o)-16(cedur)-23.9(es )]TJ 0.224 Tw -1.796 -1.25 Td [(in pil)30(onid)42(al sinus disease: A me)-12(t)15(a-anal)35(y)-13(sis, mer)-31.9(ged d)42(a)15(t)15.1(a anal)35(y)-12.9(sis, )]TJ 0.17 Tw T* [(and com)10.1(p)24.9(r)-23.9(ehensi)-16(ve stud)17(y on r)-24(ecur)-24(r)-23.9(ence. )]TJ /T1_2 1 Tf [(Sci R)21(ep. )]TJ /T1_1 1 Tf 0 Tw (2018;8\(1\):3058. )Tj T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1038/s41598-018-20143-4)Tj 0 0 0 1 k /GS1 gs 0.227 Tw -1.847 -1.25 Td (13.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Al)30(v)-15(andipour)]TJ /Span<>> BDC ( )Tj EMC 5.297 0 Td [(M, )0.5(Z)10(amani)]TJ /Span<>> BDC ( )Tj EMC [(MS, )0.5(Ghor)-24(bani)]TJ /Span<>> BDC ( )Tj EMC 10.54 0 Td [(M, e)-11.9(t)]TJ /Span<>> BDC ( )Tj EMC [(al. )0.5(Com)10(p)32(ar)-37(ison )0.5(of )]TJ -0.039 Tw -17.634 -1.25 Td [(L)-32(imber)-31.9(g Fl)-15.9(ap and K)-16(ar)-23.9(yd)42(ak)-16(is Fl)-16(ap Sur)-32(ger)-24(y for t)-13(he T)50(r)-24(ea)15(tment of P)40.1(a)14.9(t)-31.9(ients )]TJ 0.096 Tw T* [(W)-16(i)-24(t)-12.9(h P)-24(il)30(onid)42(al S)-16(inus Disease: )0.5(A S)-16(ingle-Bl)-31(inded P)40.1(ar)-33(allel R)-10(and)-16(omized )]TJ 0.016 Tc -0.016 Tw T* [(S)15.4(tud)17.4(y. )]TJ /T1_2 1 Tf 0.571 Tw 3.455 0 Td [(Ann )0.5(Colop)46.4(roctol)]TJ /T1_1 1 Tf [(. )0.6(2019;35\(6\):313\226318. )0.5(d)-15.6(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs -0.016 Tw 20.334 0 Td (10.3393/)Tj 0 Tc 0 Tw -23.789 -1.25 Td [(a)-17(c.2018.09.27)]TJ 0 0 0 1 k /GS1 gs -0.026 Tw T* (14.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Boshnaq)Tj /Span<>> BDC ( )Tj EMC 3.624 0 Td (M, Phan)Tj /Span<>> BDC ( )Tj EMC [(Y)32(C, )0.5(Mar)-22(t)-32(ini)]TJ /Span<>> BDC ( )Tj EMC 7.719 0 Td [(I, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. )0.5(L)-32(imber)-32(g )0.5(fl)-16(ap in )0.5(mana)-17(gement )]TJ 0.041 Tw -13.139 -1.25 Td [(of )0.5(pil)30.1(onid)42(al )0.5(sinus )0.6(disease: )0.6(sy)-13(stema)15(t)-32(ic )0.6(r)-24(ev)-16(iew )0.6(and )0.5(a )0.5(l)30(o)-15.9(cal )0.5(e)-18(xper)-36.9(ience. )]TJ /T1_2 1 Tf 0.218 Tw T* (Acta Chir Belg.)Tj /T1_1 1 Tf [( 2018;118\(2\):78\22684. d)-15.9(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1080/00015458.2018.)Tj T* (1430218)Tj /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\033\030\031\030\213\b)-20.9(\035\231\213\233\t \021\032)50(\b)42(\032\231\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj /T1_3 1 Tf 25 0 0 25 505.4271 56.0378 Tm (135)Tj ET endstream endobj 1003 0 obj <>/Border[0 0 0]/H/N/Rect[42.5197 738.512 104.031 729.216]/Subtype/Link/Type/Annot>> endobj 1004 0 obj <>/Border[0 0 0]/H/N/Rect[57.2978 698.512 184.105 689.216]/Subtype/Link/Type/Annot>> endobj 1005 0 obj <>/Border[0 0 0]/H/N/Rect[57.2978 648.512 192.105 639.216]/Subtype/Link/Type/Annot>> endobj 1006 0 obj <>/Border[0 0 0]/H/N/Rect[132.94 618.512 226.411 609.216]/Subtype/Link/Type/Annot>> endobj 1007 0 obj <>/Border[0 0 0]/H/N/Rect[289.739 708.512 387.21 699.216]/Subtype/Link/Type/Annot>> endobj 1008 0 obj <>/Border[0 0 0]/H/N/Rect[465.275 668.512 496.063 659.056]/Subtype/Link/Type/Annot>> endobj 1009 0 obj <>/Border[0 0 0]/H/N/Rect[274.961 658.512 321.4 649.216]/Subtype/Link/Type/Annot>> endobj 1010 0 obj <>/Border[0 0 0]/H/N/Rect[413.415 628.512 496.063 619.056]/Subtype/Link/Type/Annot>> endobj 1011 0 obj <>/Border[0 0 0]/H/N/Rect[274.961 618.512 302.961 609.216]/Subtype/Link/Type/Annot>> endobj 1020 0 obj <> endobj 1019 0 obj <> endobj 1018 0 obj <> endobj 1017 0 obj <> endobj 1016 0 obj <> endobj 1015 0 obj <> endobj 1014 0 obj <> endobj 1013 0 obj <> endobj 1012 0 obj <> endobj 999 0 obj [1021 0 R 1022 0 R 1023 0 R 1024 0 R 1025 0 R 1026 0 R 1027 0 R 1028 0 R 1029 0 R 1030 0 R 1031 0 R 1032 0 R 1033 0 R 1034 0 R 1035 0 R 1036 0 R 1037 0 R 1038 0 R 1039 0 R 1040 0 R 1041 0 R 1042 0 R 1043 0 R 1044 0 R 1045 0 R 1046 0 R 1047 0 R 1048 0 R] endobj 1000 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.437 Tw 10 0 0 10 70.8661 724.8299 Tm (\017\n. \023\030\024\235\036\f\f\024\030\026 \221.\200. \210\004\026\023\ \024\r\f\022\024\020\024\273 \204\017\027\017\f\021\036\030\f\021\r\026 \ )Tj 0.925 Tw 0 -1.218 TD [(\007\030\026\r\024\024\b\030\026\027\036\027\017\016 )0.6(\025\030\026\f\027\024\007\026\030\f\022\024\020\024 )0.6(\022\030\026\016; )0.6(ORCID )]TJ 0 Tw T* (0000-0002-0864-3938)Tj -0.039 Tw T* (\207\026\030\t\001\036\r \202\035\036\022\f\026\027\007\030 \206\036\027\ \027\026\007\034\036\r\017\004)Tj /Span<>> BDC ( )Tj EMC (\227 \007\024\022\021\024\030 \n\036\007\017\006\017\027)Tj 0 Tw (-)Tj 0.019 Tw T* (\f\022\017\b \027\026\031\022, \007\024\006\036\027\021, \026\n\036\f\021\ \017\021\036\035\034 \020\035\026\r\027\024\020\024 \r\030\026\004\026 \023\ \024)Tj /Span<>> BDC ( )Tj EMC (\b\017)Tj 0 Tw (-)Tj 0.005 Tw T* (\030\031\030\020\017\017 \206\207\211\003 \253\203\026\031\004\027\024-\017\ \f\f\035\036\007\024\r\026\021\036\035\034\f\022\017\005 \017\027\f\021\017\ \021\031\021)Tj /Span<>> BDC ( )Tj EMC (\227 )Tj 0.073 Tw 0 -1.218 TD (\025\030\026\036\r\026\016 \022\035\017\027\017\004\036\f\022\026\016 \002\ \024\035\034\027\017\006\026 \225 1 \017\n. \023\030\024\235\036\f\f\024\ \030\026 )Tj 0.364 Tw 0 -1.218 TD (\221.\200. \210\004\026\023\024\r\f\022\024\020\024\273 \204\017\027\017\ \f\021\036\030\f\021\r\026 \007\030\026\r\024\024\b\030\026\027\036\027\ \017\016 )Tj 0.431 Tw T* (\025\030\026\f\027\024\007\026\030\f\022\024\020\024 \022\030\026\016; \ \026\r\036\007\031\033\013\017\005 \022\026\235\036\007\030\024\005 \b\017\ )Tj 0 Tw (-)Tj 0.118 Tw T* (\030\031\030\020\017\017 \225 1 \205\215\025 \017)Tj /Span<>> BDC ( )Tj EMC (\215\215\221 \205\206\207\210\211 \200\210 \253\025\031\002\026\027\f\022\ \017\005 \020\024\f\031)Tj 0 Tw (-)Tj 0.139 Tw T* (\007\026\030\f\021\r\036\027\027\t\005 \n\036\007\017\006\017\027\f\022\017\ \005 \031\027\017\r\036\030\f\017\021\036\021\273 \204\017\027\007\030\026\ \r\026 )Tj 0 Tw T* (\217\024\f\f\017\017; ORCID 0000-0002-6735-3877)Tj 0.263 Tw 23.244 13.396 Td (\230\030\017\026\027\007\026\235\017\035\024\r \025\024\027\f\021\026\027\ \021\017\027 \200\035\026\007\017\n\017\030\024\r\017\004)Tj /Span<>> BDC ( )Tj EMC (\227 \r\030\026\004-)Tj 0.503 Tw T* (\b\017\030\031\030\020, \026\r\036\007\031\033\013\017\005 \024\021\007\ \036\035\036\027\017\036\n \020\027\024\005\027\024\005 \b\017\030\031\030\ )Tj 0 Tw (-)Tj 0.367 Tw T* (\020\017\017 \206\207\211\003 \253\203\026\031\004\027\024-\017\f\f\035\036\ \007\024\r\026\021\036\035\034\f\022\017\005 \017\027\f\021\017\021\031\021\ )Tj /Span<>> BDC ( )Tj EMC (\227 )Tj 0.073 Tw T* (\025\030\026\036\r\026\016 \022\035\017\027\017\004\036\f\022\026\016 \002\ \024\035\034\027\017\006\026 \225 1 \017\n.)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\235\036\f\f\024\030\026 )Tj 0.364 Tw T* (\221.\200. \210\004\026\023\024\r\f\022\024\020\024\273 \204\017\027\017\ \f\021\036\030\f\021\r\026 \007\030\026\r\024\024\b\030\026\027\036\027\ \017\016 )Tj 0 Tw T* (\025\030\026\f\027\024\007\026\030\f\022\024\020\024 \022\030\026\016; O\ RCID 0000-0001-5995-750\216)Tj /T1_1 1 Tf 0.023 Tw 0 -2.436 TD (INFORMATION ABOUT THE AUTHORS \(ORCID\))Tj /T1_0 1 Tf 0 Tw 0 -1.218 TD [(Er)-37(ic N. S)-15.9(hubr)-32(ov)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0002-0864-3938)Tj T* [(Ale)-18(x)-10.9(ander G. Bar)-23.9(y)-13(shev)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0002-6735-3877)Tj T* [(K)25(onst)15(ant)-32(in V. T)50.1(r)-37(iand)42(a\237l)30(ov)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0001-5995-750\216)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 70.936 554.3379 Tm [(\r\031\024\034\033)48(\026)45(\024)-10(\223\033)48(\026)]TJ 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0 Tc 0.333 Tw 8 0 0 8 70.8661 541.5032 Tm (1.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (\221\036\030\020\026\006\022\017\005)Tj /Span<>> BDC ( )Tj EMC (\025.\222., \203\017\022\024\035\034\f\022\017\005)Tj /Span<>> BDC ( )Tj EMC (\200.\222., \247\027\020\031\030\026\024\r)Tj /Span<>> BDC ( )Tj EMC (\217.\205., \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. )Tj 0.01 Tc 0.371 Tw -1.296 -1.25 Td [(\216\017\030\031\030\020\017\004\036\f\022\017\036 )0.5(\026\f\023\036\022\021\t )0.5(\035\036\004\036\027\017\016 \220\023\017\021\036\035\017\026\035\034\027\ \024\020\024 \022\024\023\004\017\022\024\r\024\020\024)10( )]TJ 0 Tc 0.296 Tw 0 -1.25 TD (\b\024\007\026: \024\021 \023\036\030\r\024\017\f\021\024\004\027\017\022\ \024\r \022)Tj /Span<>> BDC ( )Tj EMC (\f\024\r\030\036\n\036\027\027\024\f\021\017)Tj /T1_3 1 Tf (. \215\016\027\031\t\024\025\002 \027\020\t\001\025\004 )Tj 0.01 Tc 0.378 Tw T* (\205\006\031\005\021\020\004 \016\026\027\031\030\031\021\025\017.)Tj /T1_0 1 Tf 0 Tc 0 Tw ( )Tj /T1_3 1 Tf 0.01 Tc 0.378 Tw 9.315 0 Td (\n\027\n\023\204\t\013\025\017 \032\031\202\025\n\021.)Tj /T1_0 1 Tf 0 Tc 0 Tw ( )Tj /T1_3 1 Tf 0.01 Tc 0.378 Tw 9.488 0 Td (\240\031\030\025\203\025\021\t\013\025\031 \021\026\205\013\025)Tj /T1_0 1 Tf 0 Tc 0 Tw (. )Tj 0.023 Tw -18.803 -1.25 Td [(2022;2:92\226106. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.21685/2072-3032-2022-2-10)Tj 0 0 0 1 k /GS1 gs 0.004 Tc 0.349 Tw T* (2.)Tj /Span<>> BDC ( )Tj EMC 1.307 0 Td [(S)-15.6(hif)-55.5(fman)]TJ /Span<>> BDC ( )Tj EMC [(MA. H)0.5(ist)17.4(or)-23.6(y and Gener)-32.6(al)0.5( Infor)-15.5(ma)15.4(t)-31.6(ion on P)-23.5(il)30.4(onid)42.4(al)4( )]TJ 0 Tc 0.05 Tw -1.307 -1.25 Td [(Cy)-13(sts and S)-16(inuses. In S)-15.9(hif)-56(fman)]TJ /Span<>> BDC ( )Tj EMC [(M.A., L)35(o)-14(w)]TJ /Span<>> BDC ( )Tj EMC [(M. edi)-24(t)17.1(or)-10(s. R)13(ecent Cl)-31(inical )]TJ 0.081 Tw T* [(T)40(echniques, R)13(esul)56(ts, and R)13(esear)-31.9(ch in W)20(ounds. )]TJ /T1_3 1 Tf [(Sp)46(r)-36.9(ing)11.9(er Inter)-13.9(national )]TJ 0 Tw T* (Publishing.)Tj /T1_0 1 Tf 0.023 Tw ( 2017; p.)Tj /Span<>> BDC ( )Tj EMC [(161\226167. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1007/15695_2017_7)Tj 0 0 0 1 k /GS1 gs 0.005 Tw T* (3.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (\203\036\004\026\005)Tj /Span<>> BDC ( )Tj EMC (\222.\202., \204\026\035\034\006\036\r)Tj /Span<>> BDC ( )Tj EMC (\203.\215. \204\026\035\024\017\027\r\026\017\r\027\t\036 \n\036\021\024\ \007\017\022\017 \r)Tj /Span<>> BDC ( )Tj EMC (\035\036\004\036\027\017\017 )Tj 0.009 Tc 0.353 Tw -1.296 -1.25 Td (\023\017\035\024\027\017\007\026\035\034\027\024\005 \002\024\035\036\027\ \017 \(\024\002\024\030 \035\017\021\036\030\026\021\031\030\t\). )Tj /T1_3 1 Tf (\216\031\t\024\021\025\013 \004\025\032\205\032)Tj 0 Tc 0 Tw (-)Tj 0.096 Tw T* (\202\025\025 \025\003\031\021\025 \215.\215. \210\032\031\013\n\027\026.\ )Tj /T1_0 1 Tf [( 2019;178\(3\):69\22673. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.24884/0042-)Tj T* (4625-2019-178-3-69-73)Tj 0 0 0 1 k /GS1 gs 0.076 Tw T* (4.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Albab)16(t)15(ain)]TJ /Span<>> BDC ( )Tj EMC (IT, Alkhaldi)Tj /Span<>> BDC ( )Tj EMC 9.084 0 Td [(A, Ald)-16(osar)-36.9(i)]TJ /Span<>> BDC ( )Tj EMC [(L, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. P)-24(il)30(onid)42(al sinus disease )]TJ 0.296 Tw -10.38 -1.25 Td [(r)-24(ecur)-23.9(r)-24(ence a)15(t a ter)-22(t)-32(iar)-23.9(y car)-24(e center in R)-24(iy)22(adh. )]TJ /T1_3 1 Tf (Ann Saudi Med.)Tj /T1_0 1 Tf 0 Tw ( )Tj 0.023 Tw T* [(2021;41\(3\):179\226185. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.5144/0256-4947.2021.1799)Tj 0 0 0 1 k /GS1 gs 0.1 Tw T* (5.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Gior)-23.9(d)41.9(ano)]TJ /Span<>> BDC ( )Tj EMC [(P, S)-24(chembar)-37(i)]TJ /Span<>> BDC ( )Tj EMC [(E, K)25.1(eshishian)]TJ /Span<>> BDC ( )Tj EMC [(K, e)-12(t.al. Nega)15(t)-32(i)-16(ve p)25(r)-24(essur)-24(e-)]TJ 0.002 Tc 0.35 Tw -1.296 -1.25 Td [(assisted end)-16(oscopic pil)29.9(onid)42(al )0.5(sinus tr)-24(ea)14.9(tment. )]TJ /T1_3 1 Tf 20.679 0 Td [(T)53.9(ech Colop)45.9(roctol.)]TJ /T1_0 1 Tf 0 Tc 0 Tw 6.959 0 Td ( )Tj 0.023 Tw -27.638 -1.25 Td [(2021;25\(6\):739\226743. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1007/s10151-021-02431-w)Tj 0 0 0 1 k /GS1 gs 0.012 Tw T* (6.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (\203\036\004\026\005)Tj /Span<>> BDC ( )Tj EMC (\222.\202., \207\024\032\004\036\027\022\024)Tj /Span<>> BDC ( )Tj EMC (\202.\202., \204\026\035\034\006\036\r)Tj /Span<>> BDC ( )Tj EMC (\203.\215., \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. \210\023\036\030\026\021\017\r\027\024\036 )Tj 0.012 Tc 0.456 Tw -1.296 -1.25 Td (\035\036\004\036\027\017\036 \220\023\017\021\036\035\017\026\035\034\027\ \t\b \022\024\023\004\017\022\024\r\t\b \b\024\007\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\017\f\023\024\035\034\024\r\026\027\017)Tj 0 Tc 0 Tw (-)Tj 0.183 Tw T* (\036\n \253\026\022\030\t\021\t\b\273 \n\036\021\024\007\017\022. )Tj /T1_3 1 Tf (\216\031\t\024\021\025\013 \004\025\032\205\032\202\025\025 \025\003\031\ \021\025 \215.\215.)Tj /Span<>> BDC ( )Tj EMC (\210\032\031\013\n\027\026)Tj /T1_0 1 Tf 0 Tw (. )Tj 0.023 Tw T* [(2022;181\(2\):33\22638. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.24884/0042-4625-2022-181-2-33-38)Tj 0 0 0 1 k /GS1 gs -0.022 Tw T* (7.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (Bi)Tj /Span<>> BDC ( )Tj EMC (S, Sun)Tj /Span<>> BDC ( )Tj EMC (K, Chen)Tj /Span<>> BDC ( )Tj EMC [(S, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Sur)-32(gical p)25(r)-32(o)-16(cedur)-23.9(es in t)-13(he pil)30(onid)42(al sinus )]TJ 0.205 Tw -1.296 -1.25 Td [(disease: a sy)-13(stema)15.1(t)-32(ic r)-24(ev)-16(iew and ne)-12(t)-32(w)-14(or)-24(k me)-12(t)15(a-anal)35.1(y)-13(sis. )]TJ /T1_3 1 Tf [(Sci R)21(ep.)]TJ /T1_0 1 Tf 0 Tw ( )Tj 0.023 Tw T* [(2020;10\(1\):13720. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1038/s41598-020-70641-7)Tj 0 0 0 1 k /GS1 gs 0.128 Tw T* (8.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(T)40(enzin L)-31.9(amd)41.9(ar)-23.9(k, R)-10(aphael Nicol)-15.9(as V)18(uille-di)-23.9(t-Bille, Isabell)-15.9(a Naomi )]TJ 0.189 Tw -1.296 -1.25 Td [(Biel)-31(ick)-15.9(i, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. T)49.9(r)-23.9(ea)15(tment S)15(tr)-33(a)15(tegies for P)-24(il)30.1(onid)41.9(al S)-16(inus Disease in )]TJ 0.004 Tc 0.349 Tw 29.055 33.75 Td [(Swi)-23.9(tzer)-29.9(l)-15.9(and and A)10.1(ustr)-36.9(ia. )]TJ /T1_3 1 Tf -0.004 Tw (Medicina)Tj /T1_0 1 Tf 0.349 Tw [(. 2020;56:341. d)-15.9(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs -0.004 Tw (10.3390/)Tj 0 Tc 0 Tw T* [(medic)-24(ina56070341)]TJ 0 0 0 1 k /GS1 gs -0.037 Tw T* (9.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (\003\024\035\024\021\031\b\017\027)Tj /Span<>> BDC ( )Tj EMC (\212.\221., \221\036\030\020\017\005\022\024)Tj /Span<>> BDC ( )Tj EMC (\221.\200., \025\030\024\004\036\022)Tj /Span<>> BDC ( )Tj EMC (\222.\200. \221\024\r\030\036\n\036\027\027\t\036 \n\036\021\024\007\t )Tj 0.148 Tw -1.296 -1.25 Td (\035\036\004\036\027\017\016 \220\023\017\021\036\035\017\026\035\034\027\ \024\020\024 \022\024\023\004\017\022\024\r\024\020\024 \b\024\007\026. \ )Tj /T1_3 1 Tf (\220\026\027\032\025\006\031\t\013\025\017 \003\031\030\025\013\n-)Tj 0.243 Tw T* (\005\025\n\023\n\202\025\006\031\t\013\025\017 \027\031\t\024\021\025\013\ .)Tj /T1_0 1 Tf [( 2021;24\(1\):80\22688. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.37279/2070-)Tj T* (8092-2021-24-1-80-88)Tj 0 0 0 1 k /GS1 gs 0.012 Tc 0.438 Tw T* (10.)Tj /Span<>> BDC ( )Tj EMC 1.843 0 Td (\216\026\030\026\002\036\021)Tj /Span<>> BDC ( )Tj EMC (\213.\222., \206\030\024\001\017\035\017\027)Tj /Span<>> BDC ( )Tj EMC (\200.\221., \215\024\030\024\005\f\022\017\005)Tj /Span<>> BDC ( )Tj EMC (\221.\200., \017)Tj /Span<>> BDC ( )Tj EMC [(\f\024\026\r\021.)12( )]TJ 0 Tc 0.128 Tw -1.843 -1.25 Td (\217\036\031\035\034\021\026\021\t \r\027\036\007\030\036\027\017\016 \027\ \024\r\024\020\024 \007\r\031\b\220\021\026\023\027\024\020\024 \n\036\021\ \024\007\026 \035\036\004\036\027\017\016 \220\023\017)Tj 0 Tw (-)Tj 0.003 Tc 0.35 Tw T* (\021\036\035\017\026\035\034\027\024\020\024 \022\024\023\004\017\022\024\ \r\024\020\024 \b\024\007\026. )Tj /T1_3 1 Tf (\216\031\t\024\021\025\013 \216\n\023\202\n\202\032\026\030\t\013\n\202\n\ \202\n\t\205)Tj 0 Tc 0 Tw (-)Tj 0.101 Tw T* (\030\026\032\t\024\027\031\021\021\n\202\n \003\031\030\025\203\025\021\t\ \013\n\202\n \205\021\025\027\031\032\t\025\024\031\024\026.)Tj /T1_0 1 Tf ( 2022;19\(3\):115\226120. )Tj 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.19163/1994-9480-2022-19-3-115-120)Tj 0 0 0 1 k /GS1 gs 0.037 Tw -1.847 -1.25 Td (11.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Iesalniek)-9.9(s)]TJ /Span<>> BDC ( )Tj EMC (I, Ommer)Tj /Span<>> BDC ( )Tj EMC [(A, P)30(e)-12(ter)-10(sen)]TJ /Span<>> BDC ( )Tj EMC [(S, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Ger)-15.9(man na)15(t)-32(ional guide)]TJ 0 Tw (-)Tj 0.01 Tw -1.796 -1.25 Td [(l)-31(ine )0.6(on )0.5(t)-13(he )0.6(mana)-17(gement )0.6(of )0.5(pil)30(onid)42(al )0.6(disease. )]TJ /T1_3 1 Tf 0 Tw 18.384 0 Td [(Lang)12(enbeck)-22.9(s)]TJ /T1_0 1 Tf ( )Tj /T1_3 1 Tf 0.01 Tw 5.224 0 Td [(Arch )0.6(Surg.)]TJ /T1_0 1 Tf 0 Tw ( )Tj 0.023 Tw -23.608 -1.25 Td [(2016;401\(5\):599\226609. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1007/s00423-016-1463-7)Tj 0 0 0 1 k /GS1 gs -0.007 Tw T* (12.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(S)15(t)15(auf)-56(fer)]TJ /Span<>> BDC ( )Tj EMC [(VK, L)35(uedi)]TJ /Span<>> BDC ( )Tj EMC [(MM, K)-16(auf)]TJ /Span<>> BDC ( )Tj EMC [(P, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Common sur)-32(gical p)25(r)-32(o)-16(cedur)-23.9(es )]TJ 0.224 Tw -1.796 -1.25 Td [(in pil)30(onid)42(al sinus disease: A me)-12(t)15(a-anal)35(y)-13(sis, mer)-31.9(ged d)42(a)15(t)15.1(a anal)35(y)-12.9(sis, )]TJ 0.17 Tw T* [(and com)10.1(p)24.9(r)-23.9(ehensi)-16(ve stud)17(y on r)-24(ecur)-24(r)-23.9(ence. )]TJ /T1_3 1 Tf [(Sci R)21(ep. )]TJ /T1_0 1 Tf 0 Tw (2018;8\(1\):3058. )Tj T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1038/s41598-018-20143-4)Tj 0 0 0 1 k /GS1 gs 0.227 Tw -1.847 -1.25 Td (13.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Al)30(v)-15(andipour)]TJ /Span<>> BDC ( )Tj EMC 5.297 0 Td [(M, )0.5(Z)10(amani)]TJ /Span<>> BDC ( )Tj EMC [(MS, )0.5(Ghor)-24(bani)]TJ /Span<>> BDC ( )Tj EMC 10.54 0 Td [(M, e)-11.9(t)]TJ /Span<>> BDC ( )Tj EMC [(al. )0.5(Com)10(p)32(ar)-37(ison )0.5(of )]TJ -0.039 Tw -17.634 -1.25 Td [(L)-32(imber)-31.9(g Fl)-15.9(ap and K)-16(ar)-23.9(yd)42(ak)-16(is Fl)-16(ap Sur)-32(ger)-24(y for t)-13(he T)50(r)-24(ea)15(tment of P)40.1(a)14.9(t)-31.9(ients )]TJ 0.096 Tw T* [(W)-16(i)-24(t)-12.9(h P)-24(il)30(onid)42(al S)-16(inus Disease: )0.5(A S)-16(ingle-Bl)-31(inded P)40.1(ar)-33(allel R)-10(and)-16(omized )]TJ 0.016 Tc -0.016 Tw T* [(S)15.4(tud)17.4(y. )]TJ /T1_3 1 Tf 0.571 Tw 3.455 0 Td [(Ann )0.5(Colop)46.4(roctol)]TJ /T1_0 1 Tf [(. )0.6(2019;35\(6\):313\226318. )0.5(d)-15.6(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs -0.016 Tw 20.334 0 Td (10.3393/)Tj 0 Tc 0 Tw -23.789 -1.25 Td [(a)-17(c.2018.09.27)]TJ 0 0 0 1 k /GS1 gs -0.026 Tw T* (14.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Boshnaq)Tj /Span<>> BDC ( )Tj EMC 3.624 0 Td (M, Phan)Tj /Span<>> BDC ( )Tj EMC [(Y)32(C, )0.5(Mar)-22(t)-32(ini)]TJ /Span<>> BDC ( )Tj EMC 7.719 0 Td [(I, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. )0.5(L)-32(imber)-32(g )0.5(fl)-16(ap in )0.5(mana)-17(gement )]TJ 0.041 Tw -13.139 -1.25 Td [(of )0.5(pil)30.1(onid)42(al )0.5(sinus )0.6(disease: )0.6(sy)-13(stema)15(t)-32(ic )0.6(r)-24(ev)-16(iew )0.6(and )0.5(a )0.5(l)30(o)-15.9(cal )0.5(e)-18(xper)-36.9(ience. )]TJ /T1_3 1 Tf 0.218 Tw T* (Acta Chir Belg.)Tj /T1_0 1 Tf [( 2018;118\(2\):78\22684. d)-15.9(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1080/00015458.2018.)Tj T* (1430218)Tj /T1_2 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 70.936 237.7099 Tm (REFERENCES)Tj 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0 Tc 0.212 Tw 8 0 0 8 70.8661 224.8752 Tm (1.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Ser)-32(ga)15(tsk)-15.9(iy)]TJ /Span<>> BDC ( )Tj EMC [(K.I., Nikol\245sk)-16(iy V.I., Y)50(angur)-32.9(a)-24(zov)]TJ /Span<>> BDC ( )Tj EMC [(R.F., e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Sur)-32(gical )]TJ 0.317 Tw -1.296 -1.25 Td [(aspec)-16(ts of t)-13(he tr)-24(ea)15(tment of epi)-24(t)-13(hel)-30.9(ial pil)30(onid)42(al cy)-13(st: fr)-31.9(om p)25(r)-37(i)]TJ 0 Tw (-)Tj 0.337 Tw T* [(mar)-24(y sour)-32(ces t)17(o t)-13(he p)25(r)-24(esent \(a r)-23.9(ev)-16(iew of l)-31(i)-24(ter)-32.9(a)15(tur)-24(e\). )]TJ /T1_3 1 Tf 0 Tw [(Izv)13(estiya )]TJ 0.011 Tc 0.412 Tw T* [(vysshikh uchebn)10.9(ykh zav)12.9(edeniy. P)14.9(ov)12.9(olzhskiy region. Meditsinskie)11( )]TJ 0.01 Tc 0.372 Tw T* (nauki)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC 3.981 0 Td [(U)22(niv)13.1(ersity p)46.1(roceedings.)]TJ /T1_0 1 Tf 0 Tc 0 Tw ( )Tj /T1_3 1 Tf 0.01 Tc 0.372 Tw 10.214 0 Td [(V)32(olg)12.1(a region. )0.5(Medical )0.5(sciences)]TJ /T1_0 1 Tf 0 Tc 0 Tw (. )Tj 0.023 Tw -14.195 -1.25 Td [(2022;\(2\):92\226106. \(In Russ.\). d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.21685/2072-3032-2022-2-10)Tj 0 0 0 1 k /GS1 gs 0.004 Tc 0.349 Tw T* (2.)Tj /Span<>> BDC ( )Tj EMC 1.307 0 Td [(S)-15.6(hif)-55.5(fman)]TJ /Span<>> BDC ( )Tj EMC [(MA. H)0.5(ist)17.4(or)-23.6(y and Gener)-32.6(al)0.5( Infor)-15.5(ma)15.4(t)-31.6(ion on P)-23.5(il)30.4(onid)42.4(al)4( )]TJ 0 Tc 0.05 Tw -1.307 -1.25 Td [(Cy)-13(sts and S)-16(inuses. In S)-15.9(hif)-56(fman)]TJ /Span<>> BDC ( )Tj EMC [(M.A., L)35(o)-14(w)]TJ /Span<>> BDC ( )Tj EMC [(M. edi)-24(t)17.1(or)-10(s. R)13(ecent Cl)-31(inical )]TJ 0.081 Tw T* [(T)40(echniques, R)13(esul)56(ts, and R)13(esear)-31.9(ch in W)20(ounds. )]TJ /T1_3 1 Tf [(Sp)46(r)-37(ing)12(er Inter)-13.9(national )]TJ 0 Tw T* (Publishing.)Tj /T1_0 1 Tf 0.023 Tw [( 2017; p.161-167. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1007/15695_2017_7)Tj 0 0 0 1 k /GS1 gs -0.021 Tw T* (3.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (Nechai)Tj /Span<>> BDC ( )Tj EMC [(I.A., Mal)56(tcev)]TJ /Span<>> BDC ( )Tj EMC [(N.P. Minimall)35(y inv)-15(asi)-15.9(ve me)-12(t)-13(hods in tr)-23.9(ea)15(tment )]TJ 0.167 Tw -1.296 -1.25 Td [(of pil)30(onid)42(al disease \(r)-23.9(ev)-16(iew of t)-12.9(he l)-31(i)-23.9(ter)-33(a)15(tur)-23.9(e\). )]TJ /T1_3 1 Tf [(Grek)13(ov\242s Bulletin of )]TJ 0 Tw T* [(Surg)12(er)-43(y)]TJ /T1_0 1 Tf 0.086 Tw [(. 2019;178\(3\):69\22673. \(In Russ.\). d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.24884/0042-4625-)Tj T* (2019-178-3-69-73)Tj 0 0 0 1 k /GS1 gs 0.076 Tw T* (4.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Albab)16(t)15(ain)]TJ /Span<>> BDC ( )Tj EMC (IT, Alkhaldi)Tj /Span<>> BDC ( )Tj EMC 9.084 0 Td [(A, Ald)-16(osar)-36.9(i)]TJ /Span<>> BDC ( )Tj EMC [(L, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. P)-24(il)30(onid)42(al sinus disease )]TJ 0.296 Tw 18.675 17.5 Td [(r)-24(ecur)-23.9(r)-24(ence a)15(t a ter)-22(t)-32(iar)-23.9(y car)-24(e center in R)-24(iy)22(adh. )]TJ /T1_3 1 Tf (Ann Saudi Med.)Tj /T1_0 1 Tf 0 Tw ( )Tj 0.023 Tw T* [(2021;41\(3\):179\226185. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.5144/0256-4947.2021.1799)Tj 0 0 0 1 k /GS1 gs 0.1 Tw T* (5.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Gior)-23.9(d)41.9(ano)]TJ /Span<>> BDC ( )Tj EMC [(P, S)-24(chembar)-37(i)]TJ /Span<>> BDC ( )Tj EMC [(E, K)25.1(eshishian)]TJ /Span<>> BDC ( )Tj EMC [(K, e)-12(t.al. Nega)15(t)-32(i)-16(ve p)25(r)-24(essur)-24(e-)]TJ 0.002 Tc 0.35 Tw -1.296 -1.25 Td [(assisted end)-16(oscopic pil)29.9(onid)41.9(al )0.5(sinus tr)-24(ea)14.9(tment. )]TJ /T1_3 1 Tf 20.679 0 Td [(T)53.9(ech Colop)45.9(roctol.)]TJ /T1_0 1 Tf 0 Tc 0 Tw 6.959 0 Td ( )Tj 0.023 Tw -27.638 -1.25 Td [(2021;25\(6\):739\226743. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1007/s10151-021-02431-w)Tj 0 0 0 1 k /GS1 gs 0.007 Tc 0.35 Tw T* (6.)Tj /Span<>> BDC ( )Tj EMC 1.318 0 Td (Nechai)Tj /Span<>> BDC ( )Tj EMC (I.A., Bozhchenko)Tj /Span<>> BDC ( )Tj EMC [(A.A., Mal)55.8(tcev)]TJ /Span<>> BDC ( )Tj EMC [(N.P., e)-12.2(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Sur)-32.2(gical)7( )]TJ 0.003 Tc 0.349 Tw -1.318 -1.25 Td [(tr)-23.5(ea)15.4(tment of pi)0.5(l)30.4(onid)42.4(al diseas)0.5(e wi)-23.5(t)-12.6(h t)-12.5(he us)0.5(e of \253cl)30.4(ose)0.5(d\273)0.5( tech)]TJ 0 Tc 0 Tw 27.286 0 Td (-)Tj -27.286 -1.25 Td (niques. )Tj /T1_3 1 Tf 0.072 Tw 3.253 0 Td [(Grek)13(ov\242s )0.6(Bulletin )0.6(of )0.6(Surg)12(er)-43(y)]TJ /T1_0 1 Tf [(. )0.6(2022;181\(2\):33\22638. )0.6(\(In )0.6(Russ.\). )]TJ 0 Tw -3.253 -1.25 Td [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.24884/0042-4625-2022-181-2-33-38)Tj 0 0 0 1 k /GS1 gs -0.022 Tw -1.847 -1.25 Td (7.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (Bi)Tj /Span<>> BDC ( )Tj EMC (S, Sun)Tj /Span<>> BDC ( )Tj EMC (K, Chen)Tj /Span<>> BDC ( )Tj EMC [(S, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Sur)-32(gical p)25(r)-32(o)-16(cedur)-23.9(es in t)-13(he pil)30(onid)42(al sinus )]TJ 0.205 Tw -1.296 -1.25 Td [(disease: a sy)-13(stema)15.1(t)-32(ic r)-24(ev)-16(iew and ne)-12(t)-32(w)-14(or)-23.9(k me)-12(t)15(a-anal)35.1(y)-13(sis. )]TJ /T1_3 1 Tf [(Sci R)21(ep.)]TJ /T1_0 1 Tf 0 Tw ( )Tj 0.023 Tw T* [(2020;10\(1\):13720. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1038/s41598-020-70641-7)Tj 0 0 0 1 k /GS1 gs 0.128 Tw T* (8.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(T)40(enzin L)-31.9(amd)41.9(ar)-23.9(k, R)-10(aphael Nicol)-15.9(as V)18(uille-di)-23.9(t-Bille, Isabell)-15.9(a Naomi )]TJ 0.189 Tw -1.296 -1.25 Td [(Biel)-31(ick)-15.9(i, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. T)49.9(r)-23.9(ea)15(tment S)15(tr)-33(a)15(tegies for P)-24(il)30.1(onid)41.9(al S)-16(inus Disease in )]TJ 0.004 Tc 0.349 Tw T* [(Swi)-23.9(tzer)-29.9(l)-15.9(and and A)10.1(ustr)-36.9(ia. )]TJ /T1_3 1 Tf -0.004 Tw (Medicina)Tj /T1_0 1 Tf 0.349 Tw [(. 2020;56:341. d)-15.9(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs -0.004 Tw (10.3390/)Tj /T1_4 1 Tf 0 Tc 0 Tw 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\033\030\031\030\213\b)-20.9(\035\231\213\233\t \021\032)50(\b)42(\032\231\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj -51.938 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 23, \023\0221)69(, 202)69(4)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 23, \023\0221)69(, 202)69(4)]TJ /T1_5 1 Tf 25 0 0 25 20.8402 56.0378 Tm (134)Tj ET endstream endobj 1021 0 obj <>/Border[0 0 0]/H/N/Rect[139.366 508.799 244.542 499.503]/Subtype/Link/Type/Annot>> endobj 1022 0 obj <>/Border[0 0 0]/H/N/Rect[184.829 468.799 262.74 459.343]/Subtype/Link/Type/Annot>> endobj 1023 0 obj <>/Border[0 0 0]/H/N/Rect[239.241 438.799 291.968 429.343]/Subtype/Link/Type/Annot>> endobj 1024 0 obj <>/Border[0 0 0]/H/N/Rect[70.8661 428.799 148.946 419.503]/Subtype/Link/Type/Annot>> endobj 1025 0 obj <>/Border[0 0 0]/H/N/Rect[157.286 398.799 258.75 389.503]/Subtype/Link/Type/Annot>> endobj 1026 0 obj <>/Border[0 0 0]/H/N/Rect[157.286 368.799 255.798 359.503]/Subtype/Link/Type/Annot>> endobj 1027 0 obj <>/Border[0 0 0]/H/N/Rect[153.286 328.799 284.094 319.503]/Subtype/Link/Type/Annot>> endobj 1028 0 obj <>/Border[0 0 0]/H/N/Rect[148.838 298.799 246.31 289.503]/Subtype/Link/Type/Annot>> endobj 1029 0 obj <>/Border[0 0 0]/H/N/Rect[494.278 548.799 524.409 539.343]/Subtype/Link/Type/Annot>> endobj 1030 0 obj <>/Border[0 0 0]/H/N/Rect[303.307 538.799 364.819 529.503]/Subtype/Link/Type/Annot>> endobj 1031 0 obj <>/Border[0 0 0]/H/N/Rect[471.682 508.799 524.409 499.343]/Subtype/Link/Type/Annot>> endobj 1032 0 obj <>/Border[0 0 0]/H/N/Rect[303.307 498.799 377.387 489.503]/Subtype/Link/Type/Annot>> endobj 1033 0 obj <>/Border[0 0 0]/H/N/Rect[318.085 448.799 452.893 439.503]/Subtype/Link/Type/Annot>> endobj 1034 0 obj <>/Border[0 0 0]/H/N/Rect[393.727 418.799 487.199 409.503]/Subtype/Link/Type/Annot>> endobj 1035 0 obj <>/Border[0 0 0]/H/N/Rect[318.085 378.799 415.557 369.503]/Subtype/Link/Type/Annot>> endobj 1036 0 obj <>/Border[0 0 0]/H/N/Rect[493.622 338.799 524.409 329.343]/Subtype/Link/Type/Annot>> endobj 1037 0 obj <>/Border[0 0 0]/H/N/Rect[303.307 328.799 349.747 319.503]/Subtype/Link/Type/Annot>> endobj 1038 0 obj <>/Border[0 0 0]/H/N/Rect[441.762 298.799 524.409 289.343]/Subtype/Link/Type/Annot>> endobj 1039 0 obj <>/Border[0 0 0]/H/N/Rect[303.307 288.799 331.307 279.503]/Subtype/Link/Type/Annot>> endobj 1040 0 obj <>/Border[0 0 0]/H/N/Rect[181.77 182.171 286.946 172.875]/Subtype/Link/Type/Annot>> endobj 1041 0 obj <>/Border[0 0 0]/H/N/Rect[181.146 142.171 259.058 132.715]/Subtype/Link/Type/Annot>> endobj 1042 0 obj <>/Border[0 0 0]/H/N/Rect[220.425 112.171 291.968 102.715]/Subtype/Link/Type/Annot>> endobj 1043 0 obj <>/Border[0 0 0]/H/N/Rect[70.8661 102.171 130.13 92.8752]/Subtype/Link/Type/Annot>> endobj 1044 0 obj <>/Border[0 0 0]/H/N/Rect[389.727 222.171 491.191 212.875]/Subtype/Link/Type/Annot>> endobj 1045 0 obj <>/Border[0 0 0]/H/N/Rect[389.727 192.171 488.239 182.875]/Subtype/Link/Type/Annot>> endobj 1046 0 obj <>/Border[0 0 0]/H/N/Rect[318.085 152.171 448.893 142.875]/Subtype/Link/Type/Annot>> endobj 1047 0 obj <>/Border[0 0 0]/H/N/Rect[381.279 122.171 478.751 112.875]/Subtype/Link/Type/Annot>> endobj 1048 0 obj <>/Border[0 0 0]/H/N/Rect[494.278 92.1712 524.409 82.7152]/Subtype/Link/Type/Annot>> endobj 1076 0 obj <> endobj 1075 0 obj <> endobj 1074 0 obj <> endobj 1073 0 obj <> endobj 1072 0 obj <> endobj 1071 0 obj <> endobj 1070 0 obj <> endobj 1069 0 obj <> endobj 1068 0 obj <> endobj 1067 0 obj <> endobj 1066 0 obj <> endobj 1065 0 obj <> endobj 1064 0 obj <> endobj 1063 0 obj <> endobj 1062 0 obj <> endobj 1061 0 obj <> endobj 1060 0 obj <> endobj 1059 0 obj <> endobj 1058 0 obj <> endobj 1057 0 obj <> endobj 1056 0 obj <> endobj 1055 0 obj <> endobj 1054 0 obj <> endobj 1053 0 obj <> endobj 1052 0 obj <> endobj 1051 0 obj <> endobj 1050 0 obj <> endobj 1049 0 obj <> endobj 998 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\213\025\r\020\203 \006\221\025\006\025\f \221\007\013\006)-10(\026\220\017\016\006\n)10(\025\202)10(\025 \222\013\n\002\020\026\220\205 \002\013\001\016\r\025\202)10(\025 )]TJ 0 -1 TD [(\201\016\225\016\n)-10(\026)11(\013 \221\025\006)-10(\007\016 \220\006\006\016\017\016\001\220\205 \221\220\007\025\001\220\201\ \013\007\216\001\025\203 \n\220\006)-10(\026\020)]TJ 33.357 1 Td [(A ne)11(w meth)11(od for w)11(ound defect closur)31(e af)-31(ter pilonidal sinus e)21(x)21.1(cision)]TJ /T1_1 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 42.5896 505.6259 Tm [(\037\036)10(\032\223\212\226\034\022\031\034)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf 0 Tc 0.28 Tw 10 0 0 10 42.5197 481.2699 Tm [(\215\030\017 \017\f\023\024\035\034\024\r\026\027\017\017 )0.5(\021\026\022\017\b \n\036\021\024\007\024\r \b\017\030\031\030\020\017\004\ \036\f\022\024\020\024 )]TJ 0.103 Tw 0 -1.218 TD (\035\036\004\036\027\017\016 \215\025, \022\026\022 \017\f\f\036\004\036\ \027\017\036 \f)Tj /Span<>> BDC ( )Tj EMC (\031\001\017\r\026\027\017\036\n \023\024)Tj /Span<>> BDC ( )Tj EMC (\f\030\036\007\017\027)Tj 0 Tw (-)Tj 0.079 Tw T* (\027\024\005 \035\017\027\017\017, \004\026\f\021\024\021\026 \023\024\f\ \035\036\024\023\036\030\026\006\017\024\027\027\t\b \024\f\035\024\032\027\ \036\027\017\005 )Tj 0.245 Tw T* (\n\024\032\036\021 \007\024\f\021\017\020\026\021\034 74%, \026)Tj /Span<>> BDC ( )Tj EMC (\004\026\f\021\024\021\026 \030\036\006\017\007\017\r\026)Tj /Span<>> BDC ( )Tj EMC (\227 45% )Tj 0.005 Tw T* ([11]. \215\030\017)Tj /Span<>> BDC ( )Tj EMC (\n\026\030\f\031\023\017\026\035\017\026\006\017\017 \017\n\036\036\021\ \f\016 \023\035\024\b\024\005 \022\024\f\n\036\021\017)Tj 0 Tw (-)Tj 0.036 Tw T* (\004\036\f\022\017\005 \030\036\031\035\034\021\026\021, \027\024 \023\030\ \024\006\036\027\021 \030\036\006\017\007\017\r\026 \f\027\017\032\036\027\ [12]. )Tj 0.031 Tw T* (\221)Tj /Span<>> BDC ( )Tj EMC (\r\027\036\007\030\036\027\017\036\n \017)Tj /Span<>> BDC ( )Tj EMC (\001\017\030\024\022\017\n \017\f\023\024\035\034\024\r\026\027\017\036\ \n \f\024\r\030\036\n\036\027)Tj 0 Tw (-)Tj 0.339 Tw T* [(\027\t\b )0.5(\n\036\021\024\007\024\r )0.5(\b\017\030\031\030\020\017\004\036\f\022\024\020\024 )0.6(\035\036\004\036\027\017\016 )0.5(\215\025 )0.6(\(\f\023\024\f\024\002 )]TJ -0.024 Tw T* (\025\026\030\017\007\026\022\017\f\026, \023\036\030\036\n\036\013\036\027\ \027\t\005 \035\024\f\022\031\021 \023\024)Tj /Span<>> BDC ( )Tj EMC (\214\017\n\002\036\030\020\031 \017)Tj /Span<>> BDC ( )Tj EMC (\036\020\024 )Tj 0.116 Tw T* [(\n\024\007\017\235\017\022\026\006\017\016\) \031\007\026\035\024\f\034 \ \f\027\017\017\021\034 )0.5(\004\026\f\021\024\021\031 \024\f\035\024\032\027\036\027\017\005 )]TJ 0.034 Tw T* (\007\024)Tj /Span<>> BDC ( )Tj EMC (8,5% \(\f\023\024\f\024\002 \025\026\030\017\007\026\022\017\f\026\), \026\ )Tj /Span<>> BDC ( )Tj EMC (\021\026\022\032\036 \031\n\036\027\034\001\017\021\034 \004\026)Tj 0 Tw (-)Tj T* (\f\021\024\021\031 \030\036\006\017\007\017\r\024\r \007\024)Tj /Span<>> BDC ( )Tj EMC (8% [13,14].)Tj 0.229 Tw T* (\215\030\017 \023\030\017\n\036\027\036\027\017\017 \030\026\030\026\002\ \024\021\026\027\027\024\020\024 \026\023\026\021\036\027\021\024\r\026\ \027\027\024\020\024 )Tj 0.108 Tw T* (\n\036\021\024\007\026 \b\017\030\031\030\020\017\004\036\f\022\024\020\024\ \035\036\004\036\027\017\016 \215\025 \031\007\026\035\024\f\034 \f\027\ \017\017\021\034 )Tj -0.002 Tw T* (\022\024\035\017\004\036\f\021\r\024 \022\024\005\022\024-\007\027\036\005\ \r)Tj /Span<>> BDC ( )Tj EMC (\f\021\026\006\017\024\027\026\030\036. \230\026\022\032\036 \027\026\004\ \017\n\024 )Tj 0.19 Tw T* [(\f\027\017\017\035\024\f\034 )0.6(\022\024\035\017\004\036\f\021\r\024 )0.5(\023\024\f\035\036\024\023\036\030\026\006\017\024\027\027\t\b )0.6(\030\026\027\036\r\t\b )]TJ 0.028 Tw T* (\024\f\035\024\032\027\036\027\017\005 \f)Tj /Span<>> BDC ( )Tj EMC (20% \007\024)Tj /Span<>> BDC ( )Tj EMC (4%. \223\026\f\021\024\021\026 \030\036\006\017\007\017\r\024\r \031\n\036\ \027\034)Tj 0 Tw (-)Tj -0.019 Tw T* (\001\017\035\026\f\034 \f)Tj /Span<>> BDC ( )Tj EMC (10% \007\024)Tj /Span<>> BDC ( )Tj EMC (2%, \004\021\024 \f\024\024\021\r\036\021\f\021\r\031\036\021 \024\002\013\ \036\n\017\030\024\r\t\n )Tj 0.273 Tw T* (\f\021\026\027\007\026\030\021\026\n. \204\036\027\034\001\026\016 \004\026\ \f\021\024\021\026 \024\f\035\024\032\027\036\027\017\005 \f\r\016\026\027\ \026 )Tj T* (\f)Tj /Span<>> BDC ( )Tj EMC (\031\n\036\027\034\001\036\027\017\036\n \027\026\020\030\031\022\017 \027\ \026)Tj /Span<>> BDC ( )Tj EMC (\022\024\032\027\t\036 \001\r\t; \035\031\004\001\036\005 )Tj -0.015 Tw T* [(\026\007\026\023\021\026\006\017\036\005 )0.6(\022\024\032\027\t\b )0.5(\022\030\026\036\r; )0.5(\f\255\036\n\027\024\020\024 )0.6(\b\026\030\026\022\021\036\030\026 )0.5(\027\017\021\036\005 )]TJ -0.031 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC 1.175 0 Td [(\235\026\f\006\017\017; )0.6(\023\024\f\035\024\005\027\024\020\024 )0.5(\007\030\036\027\017\030\024\r\026\027\017\016 )0.6(\030\026\027\t. )0.5(\207\024\035\034\001\026\016 )]TJ 0.318 Tw -1.175 -1.218 Td (\004\026\f\021\024\021\026 \030\036\006\017\007\017\r\024\r \r)Tj /Span<>> BDC ( )Tj EMC (\022\024\027\021\030\024\035\034\027\024\005 \020\030\031\023\023\036 \f\ \r\016\026\027\026 )Tj 0.156 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\030\026\r\017\021\017\036\n \023\024\f\035\036\024\023\036\030\026\006\ \017\024\027\027\t\b \030\026\027\036\r\t\b \024\f\035\024\032\027\036)Tj 0 Tw (-)Tj 0.117 Tw T* [(\027\017\005, \f\024\024\021\r\036\021\f\021\r\036\027\027\024, )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC [(\024\f\027\024\r\027\024\005 )0.5(\020\030\031\023\023\036 \007\026\027\027\t\005 )0.5(\023\024)]TJ 0 Tw (-)Tj T* (\022\026\026\021\036\035\034 \002\t\035 \n\036\027\034\001\036.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 42.5896 140.2859 Tm [(\020)21(\026\027\r\242\224\034\022\031\034)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf 0 Tc 0.426 Tw 10 0 0 10 42.5197 115.9299 Tm (\203\036\f\n\024\021\030\016 \027\026)Tj /Span<>> BDC ( )Tj EMC (\030\026\030\026\002\024\021\026\027\027\t\036 \f\024\r\030\036\n\036\027\ \027\t\036 \f\023\024\f\024)Tj 0 Tw (-)Tj 0.32 Tw T* (\002\t \b\017\030\031\030\020\017\004\036\f\022\024\020\024 \035\036\004\ \036\027\017\016 \215\025, \004\026\f\021\024\021\026 \024\f\035\024\032\ \027\036)Tj 0 Tw (-)Tj 0.143 Tw T* (\027\017\005 \024\f\021\026\036\021\f\016 \r\t\f\024\022\024\005, \b\024\ \021\016 \004\026\f\021\024\021\031 \030\036\006\017\007\017\r\024\r \031\ \007\026)Tj 0 Tw (-)Tj 0.099 Tw T* (\035\024\f\034 \f\027\017\017\021\034 \023\024)Tj /Span<>> BDC ( )Tj EMC (\f\030\026\r\027\036\027\017\033 \f)Tj /Span<>> BDC ( )Tj EMC (\026\030\b\026\017\004\027\t\n\017 \n\036\021\024\007\026\n\017 )Tj -0.023 Tw 23.244 42.623 Td (\035\036\004\036\027\017\016. \215\030\017)Tj /Span<>> BDC ( )Tj EMC (\023\030\017\n\036\027\036\027\017\017 \030\026\030\026\002\024\021\026\ \027\027\024\020\024 \017)Tj /Span<>> BDC ( )Tj EMC (\026\023\026\021\036\027)Tj 0 Tw (-)Tj 0.041 Tw T* (\021\024\r\026\027\027\024\020\024 \027\026\n\017 \f\023\024\f\024\002\026\ \031\007\026\035\024\f\034 \f\027\017\017\021\034 \004\026\f\021\024\021\ \031 \024\f)Tj 0 Tw (-)Tj 0.079 Tw T* (\035\024\032\027\036\027\017\005 \007\024)Tj /Span<>> BDC ( )Tj EMC (4%. \216\024\021\016 \004\026\f\021\024\021\026 \030\036\006\017\007\017\ \r\024\r \f\024\f\021\026\r\017\035\026 )Tj 0.051 Tw T* (2% \r)Tj /Span<>> BDC ( )Tj EMC (\024\f\027\024\r\027\024\005 \020\030\031\023\023\036, \007\024\f\021\024\ \r\036\030\027\024\005 \030\026\027\017\006\t \f)Tj /Span<>> BDC ( )Tj EMC (\022\024\027\021)Tj 0 Tw (-)Tj 0.303 Tw T* (\030\024\035\034\027\024\005 \020\030\031\023\023\024\005 \r\t\016\r\035\ \036\027\024 \027\036 \002\t\035\024, \024\023\036\030\026\021\017\r\027\ \t\036 )Tj 0.012 Tw T* (\r\n\036\001\026\021\036\035\034\f\021\r\026 \031)Tj /Span<>> BDC ( )Tj EMC (\007\026\027\027\024\005 \020\030\031\023\023\t \023\026\006\017\036\027\ \021\024\r \027\036 \023\030\024\017)Tj 0 Tw (-)Tj -0.04 Tw T* (\r\024\007\017\035\017\f\034 \r\r\017\007\031 \024\021\022\026\026. \223\ \021\024 \023\024\r\024\035\017\035\024 \f\024\b\030\026\027\017\021\034\ \021\030\031)Tj 0 Tw (-)Tj 0.059 Tw T* (\007\024\r\031\033 \026\022\021\017\r\027\024\f\021\034 \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r. \217\026\030\026\002\024\021\026\027\ \027\t\005 \027\026\n\017 )Tj 0.073 Tw T* [(\f\023\024\f\024\002 )0.5(\026\022\030\t\021\017\016 )0.6(\030\026\027\036\r\024\020\024 )0.5(\007\036\235\036\022\021\026 )0.5(\023\024\f\035\036 )0.6(\017\f\f\036\004\036\027\017\016 )]TJ 0.103 Tw T* (\215\025 \023\030\024\f\021 \r)Tj /Span<>> BDC ( )Tj EMC (\021\036\b\027\017\004\036\f\022\024\n \017\f\023\024\035\027\036\027\017\ \017 \017)Tj /Span<>> BDC ( )Tj EMC (\027\026\007\201\032\036\027, \004\021\024 )Tj 0 Tw T* (\023\024\r\024\035\016\036\021 \023\030\017\n\036\027\016\021\034 \036\020\ \024 \r)Tj /Span<>> BDC ( )Tj EMC (\030\031\021\017\027\027\024\005 \023\030\026\022\021\017\022\036.)Tj /T1_3 1 Tf 0.023 Tw 0 -2.436 TD (\223\030\032\255\020\034\036 \032\026\020\017\022\017\026)Tj /T1_2 1 Tf 0.382 Tw 0 -1.218 TD [(\025)-4.1(\024)-4.3(\027)1.7(\006)-6(\036)-6.8(\023)2.2(\006)-6(\017)-5.4(\016 \017)]TJ /Span<>> BDC ( )Tj EMC [(\007)-6(\017)2.8()-9.9(\026\005)1.7(\027 \017)-2.3(\f)3(\f)-38.9(\035)-6.7(\036)-19(\007)-4.4(\024)-4.3(\r)-8.9(\026\027)1.7(\017)-5.5(\016)13.7(:)]TJ /T1_4 1 Tf [( \231)5(\205)-1.8(\005)6(\032\n)9.6(\027)]TJ /Span<>> BDC ( )Tj EMC [(\230)39.1(.)29.4(\217)28.8(.)7.8(, )]TJ -0.005 Tc 0.005 Tw T* [(\213\026)-3.2(\032)-1.8(\020)4.6(\001)-1.7(\031)1.6(\027)]TJ /Span<>> BDC 3.722 0 Td ( )Tj EMC [(\201)-7.3(.)24.3(\210)117(.)2.8(,)-5( \220)44.2(\032)1.5(\025)4.4(\026)-0.6(\021)1.6(\030\026)-4.1(\f)0.5(\025)-7.3(\023)-1.7(\n)4.6(\027)]TJ /Span<>> BDC 7.943 0 Td ( )Tj EMC [(\222)3.6(.)23.5(\216)19.3(.)]TJ /T1_2 1 Tf 0 Tc 0 Tw -11.666 -1.218 Td [(\221)-4.6(\002)-9.9(\024)0.7(\030 \017)]TJ /Span<>> BDC ( )Tj EMC [(\024)-11.8(\002)3(\030)-11.3(\026)-6.4(\002)-9.9(\024)-10.8(\021)-17.7(\022)-19.1(\026 \n)1.3(\026)-11.8(\021)-9.9(\036)-1.7(\030)-7.6(\017)-0.6(\026)-33.1(\035)-2.5(\024)-4.3(\r)10.4(:)]TJ /T1_4 1 Tf -0.029 Tc 0.029 Tw [( \231)-24(\205)-30.8(\005)-22.9(\032)-29(\n)-19.3(\027)]TJ /Span<>> BDC 16.106 0 Td ( )Tj EMC [(\230)10.1(.\217.)]TJ /T1_2 1 Tf 0.018 Tc -0.057 Tw -16.106 -1.218 Td [(\221)35.2(\021)-3.5(\026)6.2(\021\017)15.7(\f)-18(\021\017)22.5(\004)9.8(\036)7.6(\f)16.4(\022)-1.1(\026)-3(\016)18( \024)6.2(\002)21(\030)6.6(\026)11.8(\002)8.1(\024)7.1(\021\022)-1.1(\026)21.7(:)]TJ /T1_4 1 Tf 0 Tc -0.039 Tw 11.31 0 Td [( \231)5.1(\205)-1.8(\005)6(\032\n)9.6(\027)]TJ /Span<>> BDC ( )Tj EMC [(\230)39.1(.)29.4(\217)28.8(.)7.8(, \213)5(\026)1.9(\032)3.1(\020)9.7(\001)3.3(\031)6.6(\027)]TJ /Span<>> BDC ( )Tj EMC [(\201)-2.3(.)29.3(\210)122(.)]TJ /T1_2 1 Tf 0.002 Tc 0.651 Tw -11.31 -1.218 Td [(\203)7.2(\026\023)4.2(\017\f)-10.8(\026)1.7(\027)3.7(\017)-6.7(\036)2.1( \021)-7.9(\036)-3.4(\022\f)-34(\021)-19.5(\026)5.7(:)]TJ /T1_4 1 Tf 0 Tc 0.653 Tw 8.347 0 Td [( \231)5(\205)-1.8(\005)6(\032\n)9.7(\027)]TJ /Span<>> BDC ( )Tj EMC [(\230)39.1(.)29.3(\217)28.8(.)7.8(, \213)5(\026)1.9(\032)3.1(\020)9.7(\001)3.3(\031)6.6(\027)]TJ /Span<>> BDC ( )Tj EMC [(\201)-2.3(.)29.3(\210)122(.)7.8(, )]TJ -0.009 Tc 0.009 Tw -8.347 -1.218 Td [(\220)40.2(\032)-2.6(\025)0.5(\026)-4.7(\021)-2.4(\030)-4.2(\026)-8.1(\f)-3.5(\025)-11.3(\023)-5.7(\n)0.7(\027)]TJ /Span<>> BDC 5.844 0 Td ( )Tj EMC [(\222.)19.5(\216)15.3(.)]TJ /T1_2 1 Tf 0 Tc 0 Tw -5.844 -1.218 Td [(\217)5.5(\036)-19(\007)-20.1(\026\022)-32.6(\021)-17.7(\017)1.4(\030)-11.8(\024)-4.2(\r)-9(\026\027)1.8(\017)-8.7(\036)6.5(:)]TJ /T1_4 1 Tf -0.005 Tc 0.005 Tw [( \213\026)-3.2(\032)-1.8(\020)4.6(\001)-1.7(\031)1.6(\027)]TJ /Span<>> BDC 11.09 0 Td ( )Tj EMC [(\201)-7.3(.)24.3(\210)117(.)2.8(,)-5( \220)44.2(\032)1.5(\025)4.4(\026)-0.6(\021)1.6(\030\026)-4.1(\f)0.5(\025)-7.3(\023)-1.7(\n)4.6(\027)]TJ /Span<>> BDC 7.943 0 Td ( )Tj EMC [(\222)3.6(.)23.5(\216)19.3(.)]TJ /T1_3 1 Tf 0 Tc 0.023 Tw -19.033 -2.436 Td (AUTHORS CONTRIBUTION)Tj /T1_2 1 Tf 0.305 Tw T* [(C)-6.5(o)0.8(nce)-0.7(p)-12.3(t a)2.4(n)-4.6(d d)-5.6(e)-13.3(s)-16.5(i)3.2(g)1.2(n o)-2.2(f t)-16.7(h)-5.3(e s)-20(t)-12.8(ud)-10.9(y)-11.8(:)]TJ /T1_4 1 Tf [( E)22(r)-35.3(i)7.9(k)]TJ /Span<>> BDC ( )Tj EMC [(N)13(.)]TJ /Span<>> BDC ( )Tj EMC [(S)15.4(h)8.2(u)6.4(b)0.8(r)2.4(o)-0.6(v)33.6(, )]TJ 0.001 Tc -0.001 Tw T* [(A)4.6(l)5.8(e)-27.6(x)6.1(ande)-0.7(r)]TJ /Span<>> BDC 3.884 0 Td ( )Tj EMC (G.)Tj /Span<>> BDC 1.041 0 Td ( )Tj EMC [(B)7.7(a)1.2(r)-39.1(ys)10.6(h)2.9(e)-3(v)34.6(,)1( K)14.4(o)1.4(n)9.1(s)-9.7(t)3.3(an)4.8(t)-24.1(i)9.4(n)]TJ /Span<>> BDC 8.41 0 Td ( )Tj EMC [(V)54.1(.)]TJ /Span<>> BDC 0.955 0 Td ( )Tj EMC [(T)52.2(r)-34.3(i)7(and)2.9(a)6.5(\233)9.1(l)3.9(ov)]TJ /T1_2 1 Tf 0 Tc 1.014 Tw -14.291 -1.218 Td [(C)-6.5(o)-5.8(l)-19(l)-14.3(e)-9.4(c)-32.5(t)-37.3(i)3.2(o)0.8(n )0.5(a)2.4(n)-4.6(d )0.6(p)-3.8(r)-6(o)-7(ce)-13.3(s)-12.8(s)-16.6(i)7.1(n)-1.9(g )0.6(o)-2.2(f )0.5(t)-16.6(h)-5.3(e )0.5(m)1.8(a)-8.4(t)-15.1(e)-2.1(r)-48(i)5.1(a)-1.5(l)-22.5(:)]TJ /T1_4 1 Tf 0 Tw ( )Tj -0.008 Tc 0.008 Tw T* [(E)14(r)-43.3(ik)]TJ /Span<>> BDC 1.506 0 Td ( )Tj EMC [(N)5(.)]TJ /Span<>> BDC 1.088 0 Td ( )Tj EMC [(S)7.3(hu)-1.6(b)-7.2(r)-5.5(o)-8.6(v)]TJ /T1_2 1 Tf -0.007 Tc 1.678 Tw -2.594 -1.218 Td [(St)-34.7(a)-15.4(t)-44.4(i)-4.3(s)-27(t)-44.4(i)-1.8(c)-18.8(a)-8.5(l)-7( )0.6(p)-10.8(r)-13(o)-14(c)-6.8(e)-20.3(s)-19.8(s)-23.6(in)-8.9(g)2(:)]TJ /T1_4 1 Tf 0 Tc 1.671 Tw 10.759 0 Td [( )0.6(E)22(r)-35.3(i)7.9(k)]TJ /Span<>> BDC ( )Tj EMC 5.313 0 Td [(N)13(.)]TJ /Span<>> BDC ( )Tj EMC 2.758 0 Td [(S)15.3(h)8.2(u)6.4(b)0.8(r)2.4(o)-0.6(v)33.6(, )]TJ 0.001 Tc -0.001 Tw -18.83 -1.218 Td [(A)4.6(l)5.8(e)-27.6(x)6.1(ande)-0.7(r)]TJ /Span<>> BDC 3.884 0 Td ( )Tj EMC (G.)Tj /Span<>> BDC 1.041 0 Td ( )Tj EMC [(B)7.7(a)1.2(r)-39.1(ys)10.6(h)2.9(e)-3(v)]TJ /T1_2 1 Tf 0.01 Tc 1.249 Tw -4.926 -1.218 Td [(W)3.1(r)-48(i)-6(t)-37.4(i)7.1(n)-1.9(g o)-2.3(f t)-16.7(h)-5.3(e t)-15.2(e)-23.9(x)-35.9(t)-20.2(:)]TJ /T1_4 1 Tf 0.002 Tc 1.258 Tw [( )0.5(E)14(r)-43.3(ik)]TJ /Span<>> BDC 14.901 0 Td ( )Tj EMC 1.492 0 Td [(N)5(.)]TJ /Span<>> BDC 0.875 0 Td ( )Tj EMC 1.492 0 Td [(S)7.3(hu)-1.6(b)-7.2(r)-5.6(o)-8.6(v)25.6(,)2( )]TJ 0.011 Tc -0.001 Tw -18.76 -1.218 Td [(A)4.6(l)5.8(e)-27.6(x)6(ande)-0.7(r)]TJ /Span<>> BDC 3.974 0 Td ( )Tj EMC (G.)Tj /Span<>> BDC 1.071 0 Td ( )Tj EMC [(B)7.7(a)1.2(r)-39.2(ys)10.6(h)2.9(e)-3(v)34.6(,)1( K)24.3(o)11.4(n)19.1(st)13.3(a)10.2(n)14.8(t)-14.1(i)19.4(n)]TJ /Span<>> BDC 8.52 0 Td ( )Tj EMC 0.233 0 Td [(V)64.1(.)]TJ /Span<>> BDC 0.722 0 Td ( )Tj EMC 0.233 0 Td [(T)62.2(r)-24.3(i)16.9(a)10.3(n)10.4(d)12.9(a)16.5(\233)19(l)13.9(o)10.4(v)]TJ /T1_2 1 Tf 0.006 Tc -0.006 Tw -14.754 -1.218 Td [(E)11.6(dit)-31.4(i)13.1(n)4.1(g)15(:)]TJ /T1_4 1 Tf 0.001 Tc -0.079 Tw 3.238 0 Td [( A)4.6(l)5.8(e)-27.6(x)6(ande)-0.7(r)]TJ /Span<>> BDC 4.04 0 Td ( )Tj EMC (G.)Tj /Span<>> BDC 0.964 0 Td ( )Tj EMC [(B)7.7(a)1.2(r)-39.2(ys)10.6(h)2.9(e)-3(v)34.6(,)1( K)14.3(o)1.4(n)9.1(s)-9.6(t)3.3(an)4.8(t)-24.2(i)9.4(n)]TJ /Span<>> BDC 8.255 0 Td ( )Tj EMC [(V)54.1(.)]TJ /Span<>> BDC 0.877 0 Td ( )Tj EMC [(T)52.2(r)-34.3(i)7(and)2.9(a)6.5(\233)9(l)4(ov)]TJ /T1_3 1 Tf 0 Tc 0.023 Tw -17.373 -2.436 Td (\255\026\036\031\036\025\034\224 \017\225 \032\026\020\017\022\032\221 \(\ ORCID\))Tj /T1_2 1 Tf 0.093 Tw T* (\234\031\002\030\024\r \224\030\017\022 \203\017\022\024\035\026\036\r\017\ \004)Tj /Span<>> BDC ( )Tj EMC (\227 \r\030\026\004-\b\017\030\031\030\020 \024\021\007\036\035\036\027\017\ \016 )Tj 0.144 Tw T* (\020\027\024\005\027\024\005 \b\017\030\031\030\020\017\017 \206\207\211\ \003 \253\203\026\031\004\027\024-\017\f\f\035\036\007\024\r\026\021\036\ \035\034\f\022\017\005 )Tj 0.372 Tw T* (\017\027\f\021\017\021\031\021)Tj /Span<>> BDC ( )Tj EMC (\227 \025\030\026\036\r\026\016 \022\035\017\027\017\004\036\f\022\026\016\ \002\024\035\034\027\017\006\026 \225 1 )Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0 Tw 9 0 0 9 42.5197 730.483 Tm (\020\004\206\f\t\204\004 1.)Tj 0 0 0 1 k /GS1 gs /T1_4 1 Tf ( \212\026\t\033\032\031\030\031\023\031\021\025\031 \033\n)Tj /Span<>> BDC ( )Tj EMC (\033\n\023\205, \027\n\016\032\026\t\024\205 \025)Tj /Span<>> BDC ( )Tj EMC (\215\240\220)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0 -1.2 TD [(T)48(able 1)47(.)]TJ 0 0 0 1 k /GS1 gs /T1_4 1 Tf [( Distr)-36.9(ibution by g)12.1(ender)61(, ag)12.1(e and BMI)]TJ ET 0 0 0 1 K 0.5 w /GS2 gs q 1 0 0 1 42.5197 715.181 cm 0 0 m 119.305 0 l S Q q 1 0 0 1 42.7697 703.9617 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 161.8248 715.181 cm 0 0 m 107.717 0 l S Q q 1 0 0 1 161.8248 703.9617 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 269.5413 715.181 cm 0 0 m 107.717 0 l S Q q 1 0 0 1 269.5413 703.9617 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 377.2579 715.181 cm 0 0 m 119.305 0 l S Q q 1 0 0 1 377.2579 703.9617 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 496.313 703.9617 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 42.5197 703.7117 cm 0 0 m 119.305 0 l S Q q 1 0 0 1 42.7697 692.5005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 161.8248 703.7117 cm 0 0 m 107.717 0 l S Q q 1 0 0 1 161.8248 692.5005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 269.5413 703.7117 cm 0 0 m 107.717 0 l S Q q 1 0 0 1 269.5413 692.5005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 377.2579 703.7117 cm 0 0 m 119.305 0 l S Q q 1 0 0 1 377.2579 692.5005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 692.5005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 692.2505 cm 0 0 m 119.305 0 l S Q q 1 0 0 1 42.7697 681.0392 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 161.8248 692.2505 cm 0 0 m 107.717 0 l S Q q 1 0 0 1 161.8248 681.0392 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 269.5413 692.2505 cm 0 0 m 107.717 0 l S Q q 1 0 0 1 269.5413 681.0392 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 377.2579 692.2505 cm 0 0 m 119.305 0 l S Q q 1 0 0 1 377.2579 681.0392 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 681.0392 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 680.7892 cm 0 0 m 119.305 0 l S Q q 1 0 0 1 42.7697 669.5779 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 161.8248 680.7892 cm 0 0 m 107.717 0 l S Q q 1 0 0 1 161.8248 669.5779 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 269.5413 680.7892 cm 0 0 m 107.717 0 l S Q q 1 0 0 1 269.5413 669.5779 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 377.2579 680.7892 cm 0 0 m 119.305 0 l S Q q 1 0 0 1 377.2579 669.5779 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 669.5779 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 669.3279 cm 0 0 m 119.305 0 l S Q q 1 0 0 1 161.8248 669.3279 cm 0 0 m 107.717 0 l S Q q 1 0 0 1 269.5413 669.3279 cm 0 0 m 107.717 0 l S Q q 1 0 0 1 377.2579 669.3279 cm 0 0 m 119.305 0 l S Q BT /GS1 gs /T1_3 1 Tf 8 0 0 8 82.1255 706.5463 Tm (\200\002\220\004\213\004\003\r\f\t)Tj 13.023 0 Td (\017\217\b\002\b\004\235 \n\006\210\212\212\004)Tj 12.711 0 Td (\021\002\b\003\006\002\f\001\b\004\235 \n\006\210\212\212\004)Tj 11.959 0 Td (\223\006\002\r\b\001 \213\b\004\201\t\214\002\217\003\t \006\004\213\f\t\ \201\t\005)Tj /T1_2 1 Tf -42.258 -1.433 Td (\200\024\030\026\f\021, \035\036\021)Tj 17.974 0 Td (25,0)Tj /Span<>> BDC ( )Tj EMC (\(23,0; 32,8\))Tj 13.465 0 Td (26,0)Tj /Span<>> BDC ( )Tj EMC (\(24,0; 32,8\))Tj /T1_4 1 Tf 15.395 0 Td (\032)Tj /T1_2 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,355*)Tj -46.833 -1.433 Td (\222\204\230, \022\020/\n)Tj 4.664 0 0 4.664 77.7399 686.2878 Tm (2)Tj 8 0 0 8 189.3953 683.6238 Tm (25,2)Tj /Span<>> BDC ( )Tj EMC (\(23,9; 28,1\))Tj 13.465 0 Td (26,0)Tj /Span<>> BDC ( )Tj EMC (\(24,0; 27,4\))Tj /T1_4 1 Tf 15.395 0 Td (\032)Tj /T1_2 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,467*)Tj -46.833 -1.433 Td (\204\031\032\004\017\027\t/\032\036\027\013\017\027\t, \(%\))Tj 18.33 0 Td (33/17)Tj /Span<>> BDC ( )Tj EMC (\(66/34\))Tj 13.465 0 Td (33/17)Tj /Span<>> BDC ( )Tj EMC (\(66/34\))Tj /T1_4 1 Tf 15.642 0 Td (\032)Tj /T1_2 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (1,0)Tj 4.664 0 0 4.664 446.1353 674.8265 Tm (#)Tj /T1_4 1 Tf 7 0 0 7 42.5197 657.8432 Tm (\032\025\003\031\006\026\021\025\031: *)Tj /Span<>> BDC ( )Tj EMC (\227 \205\032\n\027\031\021\022 \016\021\026\006\025\003\n\t\024\025 \n\033\ \032\031\030\031\023\002\023\025 \033\n)Tj /Span<>> BDC ( )Tj EMC [(\013\032\025\024\031\032\025\007 \240\026\021\021\026\226\214)50.6(\025\024\021\025, )]TJ 4.081 0 0 4.081 273.6274 660.1742 Tm (#)Tj /Span<>> BDC 7 0 0 7 275.6516 657.8432 Tm ( )Tj EMC (\227 \205\032\n\027\031\021\022 \016\021\026\006\025\003\n\t\024\025 \n\033\ \032\031\030\031\023\002\023\025 \033\n)Tj /Span<>> BDC ( )Tj EMC (\013\032\025\024\031\032\025\007 \232)Tj 4.081 0 0 4.081 425.4977 660.1742 Tm (2)Tj 7 0 0 7 427.5382 657.8432 Tm (-\025\032\t\n\021\026)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0.114 Tw 9 0 0 9 42.5197 638.5393 Tm (\020\004\206\f\t\204\004 2.)Tj 0 0 0 1 k /GS1 gs /T1_4 1 Tf ( \221\021\026\006\031\021\025\002 \003\031\030\025\026\021 \027\032\031\003\ \031\021\025 \n\033\031\032\026\203\025\025, \027\032\031\003\031\021\025\ \023\031\006\031\021\025\002 \027)Tj /Span<>> BDC ( )Tj EMC (\t\024\026\203\025\n\021\026\032\031 \(\240\031 \(Q1; Q3\)\) \025)Tj /Span<>> BDC ( )Tj EMC (\006\026\t\024\n\024\026 \n\t\023\n\204\021\031\021\025\017 )Tj 0 Tw 0 -1.2 TD (\025)Tj /Span<>> BDC ( )Tj EMC (\032\031\203\025\030\025\027\n\027 \(%\) \t\032\031\030\025 \033\026\203\ \025\031\021\024\n\027 \027)Tj /Span<>> BDC ( )Tj EMC (\t\032\026\027\021\025\027\026\031\003\020\004 \202\032\205\033\033\026\004\ )Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf -0.008 Tw 0 -1.2 TD [(T)48(able 2)16(.)]TJ 0 0 0 1 k /GS1 gs /T1_4 1 Tf [( Median v)16(alues of operation time, hospital treatment time \(\240\031 \(Q1; Q3\)\)\ , and freq)14(uency of com)16(plications and recur)-16(rences )]TJ 0 Tw 0 -1.2 TD [(\(%\) among patients in the com)16.3(pared g)14(roups)]TJ ET /GS2 gs q 1 0 0 1 42.5197 601.6373 cm 0 0 m 119.305 0 l S Q q 1 0 0 1 42.7697 590.4181 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 161.8248 601.6373 cm 0 0 m 107.717 0 l S Q q 1 0 0 1 161.8248 590.4181 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 269.5413 601.6373 cm 0 0 m 107.717 0 l S Q q 1 0 0 1 269.5413 590.4181 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 377.2578 601.6373 cm 0 0 m 119.305 0 l S Q q 1 0 0 1 377.2578 590.4181 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 496.313 590.4181 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 42.5197 590.1681 cm 0 0 m 119.305 0 l S Q q 1 0 0 1 42.7697 578.9568 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 161.8248 590.1681 cm 0 0 m 107.717 0 l S Q q 1 0 0 1 161.8248 578.9568 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 269.5413 590.1681 cm 0 0 m 107.717 0 l S Q q 1 0 0 1 269.5413 578.9568 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 377.2578 590.1681 cm 0 0 m 119.305 0 l S Q q 1 0 0 1 377.2578 578.9568 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 578.9568 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 578.7068 cm 0 0 m 119.305 0 l S Q q 1 0 0 1 42.7697 567.4955 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 161.8248 578.7068 cm 0 0 m 107.717 0 l S Q q 1 0 0 1 161.8248 567.4955 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 269.5413 578.7068 cm 0 0 m 107.717 0 l S Q q 1 0 0 1 269.5413 567.4955 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 377.2578 578.7068 cm 0 0 m 119.305 0 l S Q q 1 0 0 1 377.2578 567.4955 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 567.4955 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 567.2455 cm 0 0 m 119.305 0 l S Q q 1 0 0 1 42.7697 556.0342 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 161.8248 567.2455 cm 0 0 m 107.717 0 l S Q q 1 0 0 1 161.8248 556.0342 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 269.5413 567.2455 cm 0 0 m 107.717 0 l S Q q 1 0 0 1 269.5413 556.0342 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 377.2578 567.2455 cm 0 0 m 119.305 0 l S Q q 1 0 0 1 377.2578 556.0342 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 556.0342 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 555.7842 cm 0 0 m 119.305 0 l S Q q 1 0 0 1 42.7697 544.573 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 161.8248 555.7842 cm 0 0 m 107.717 0 l S Q q 1 0 0 1 161.8248 544.573 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 269.5413 555.7842 cm 0 0 m 107.717 0 l S Q q 1 0 0 1 269.5413 544.573 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 377.2578 555.7842 cm 0 0 m 119.305 0 l S Q q 1 0 0 1 377.2578 544.573 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 544.573 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 544.323 cm 0 0 m 119.305 0 l S Q q 1 0 0 1 161.8248 544.323 cm 0 0 m 107.717 0 l S Q q 1 0 0 1 269.5413 544.323 cm 0 0 m 107.717 0 l S Q q 1 0 0 1 377.2578 544.323 cm 0 0 m 119.305 0 l S Q BT /GS1 gs /T1_3 1 Tf 8 0 0 8 82.1255 593.0027 Tm (\200\002\220\004\213\004\003\r\f\t)Tj 13.023 0 Td (\017\217\b\002\b\004\235 \n\006\210\212\212\004)Tj 12.711 0 Td (\021\002\b\003\006\002\f\001\b\004\235 \n\006\210\212\212\004)Tj 11.959 0 Td (\223\006\002\r\b\001 \213\b\004\201\t\214\002\217\003\t \006\004\213\f\t\ \201\t\005)Tj /T1_2 1 Tf -42.258 -1.433 Td (\200\030\036\n\016 \024\023\036\030\026\006\017\017, \n\017\027\031\021\t\ )Tj 17.974 0 Td (35,0)Tj /Span<>> BDC ( )Tj EMC (\(35,0; 40,0\))Tj 13.465 0 Td (30,0)Tj /Span<>> BDC ( )Tj EMC (\(30,0; 35,0\))Tj /T1_4 1 Tf 15.395 0 Td (\032)Tj /T1_2 1 Tf /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (0,001*)Tj -46.833 -1.433 Td (\200\030\036\n\016 \035\036\004\036\027\017\016 \r)Tj /Span<>> BDC ( )Tj EMC (\f\021\026\006\017\024\027\026\030\036, \007\027\017)Tj 19.751 0 Td (7)Tj /Span<>> BDC ( )Tj EMC (\(6; 7\))Tj 13.465 0 Td (7)Tj /Span<>> BDC ( )Tj EMC (\(6; 8\))Tj /T1_4 1 Tf 13.617 0 Td (\032)Tj /T1_2 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,027*)Tj -46.833 -1.433 Td (\210\f\035\024\032\027\036\027\017\016, %)Tj 20.667 0 Td (4,0)Tj 13.215 0 Td (20,0)Tj /T1_4 1 Tf 13.056 0 Td (\032)Tj /T1_2 1 Tf /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (0,028)Tj 4.664 0 0 4.664 450.1353 561.2829 Tm (#)Tj 8 0 0 8 45.6043 547.1576 Tm (\217\036\006\017\007\017\r\t, %)Tj 20.667 0 Td (2,0)Tj 13.215 0 Td (10,0)Tj /T1_4 1 Tf 13.306 0 Td (\032)Tj /T1_2 1 Tf /Span<>> BDC ( )Tj EMC (>)Tj /Span<>> BDC ( )Tj EMC (0,09)Tj 4.664 0 0 4.664 448.1353 549.8216 Tm (#)Tj /T1_4 1 Tf 7 0 0 7 42.5197 532.8383 Tm (\032\025\003\031\006\026\021\025\031: *)Tj /Span<>> BDC ( )Tj EMC (\227 \205\032\n\027\031\021\022 \016\021\026\006\025\003\n\t\024\025 \n\033\ \032\031\030\031\023\002\023\025 \033\n)Tj /Span<>> BDC ( )Tj EMC [(\013\032\025\024\031\032\025\007 \240\026\021\021\026\226\214)50.6(\025\024\021\025, )]TJ 4.081 0 0 4.081 273.6274 535.1693 Tm (#)Tj /Span<>> BDC 7 0 0 7 275.6516 532.8383 Tm ( )Tj EMC (\227 \232)Tj 4.081 0 0 4.081 289.7563 535.1693 Tm (2)Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\033\030\031\030\213\b)-20.9(\035\231\213\233\t \021\032)50(\b)42(\032\231\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj /T1_5 1 Tf 25 0 0 25 505.4645 56.0378 Tm (133)Tj ET endstream endobj 995 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.049 Tw 10 0 0 10 70.8661 724.8299 Tm (\023\030\024\017\r\024\007\016\021 \036\032\036\007\027\036\r\027\t\036\ \023\036\030\036\r\016\022\017 \030\026\027\t \f)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\n\t\r\026)Tj 0 Tw (-)Tj 0.017 Tw 0 -1.218 TD (\027\017\036\n \023\036\030\235\024\030\017\030\024\r\026\027\027\024\020\ \024 \007\030\036\027\026\032\026 \r\024\007\027\t\n \030\026\f\021\r\024\ \030\024\n )Tj 0.115 Tw T* (\026\027\021\017\f\036\023\021\017\022\026, \022\024\021\024\030\t\005 \031\ \007\026\035\016\033\021 \r)Tj /Span<>> BDC ( )Tj EMC (\026\r\017\f\017\n\024\f\021\017 \024\021 \b\026)Tj 0 Tw (-)Tj 0.076 Tw T* (\030\026\022\021\036\030\026 \017)Tj /Span<>> BDC ( )Tj EMC (\022\024\035\017\004\036\f\021\r\026 \030\026\027\036\r\024\005 \032\017\ \007\022\024\f\021\017 \027\026)Tj /Span<>> BDC ( )Tj EMC (2\2263)Tj /Span<>> BDC ( )Tj EMC (\f\031\021)Tj 0 Tw (-)Tj 0.068 Tw T* (\022\017. \210\f\035\024\032\027\036\027\017\005 \r\024 \r\030\036\n\016\ \n\026\027\017\023\031\035\016\006\017\017 \027\036 \027\026\002\035\033\ \007\026)Tj 0 Tw (-)Tj T* (\035\024\f\034. \025\024\032\027\t\036 \001\r\t \f\027\017\n\026\033\021\ \027\026)Tj /Span<>> BDC ( )Tj EMC (10\22613)Tj /Span<>> BDC ( )Tj EMC (\f\031\021\022\017.)Tj 1.025 Tw 0 -1.218 TD (\221\021\026\021\017\f\021\017\004\036\f\022\026\016 \024\002\030\026\002\ \024\021\022\026 \007\026\027\027\t\b \023\030\024\017\r\036\007\036)Tj 0 Tw (-)Tj 0.412 Tw 0 -1.218 TD (\027\026 \023\030\017)Tj /Span<>> BDC ( )Tj EMC [(\023\024\n\024\013\017 \023\030\024\020\030\026\n\n\t Micr)-32(osof)-27.9(t E)35(x)-13(cel 2013 )]TJ 0.122 Tw 23.244 8.525 Td (\f)Tj /Span<>> BDC ( )Tj EMC (\027\026\007\f\021\030\024\005\022\026\n\017 \253\215\026\022\036\021 \202\ \027\026\035\017\026\273 \017)Tj /Span<>> BDC ( )Tj EMC [(A)30(t)-30(teS)15(t)15.1(a)15(t \007\035\016 \024\002)]TJ 0 Tw (-)Tj 0.321 Tw T* (\030\026\002\024\021\022\017 \f\021\026\021\017\f\021\017\004\036\f\022\017\ \b \007\026\027\027\t\b. \212\035\016 \024\023\030\036\007\036\035\036\027\ \017\016 )Tj 0.082 Tw T* (\f\021\026\021\017\f\021\017\004\036\f\022\024\005 \027\026\004\017\n\024\ \f\021\017 \022\024\035\017\004\036\f\021\r\036\027\027\t\b \023\030\017\ \027\026)Tj 0 Tw (-)Tj 0.181 Tw T* (\022\024\r \(\r\024\030\026\f\021, \222\204\230, \r\030\036\n\016 \024\023\ \036\030\026\006\017\017, \r\030\036\n\016 \035\036\004\036\027\017\016 \ )Tj 0.053 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\f\021\026\006\017\024\027\026\030\036\) \017\f\023\024\035\034\024\r\026\ \035\f\016 \022\030\017\021\036\030\017\005 \204\026\027\027\026-\211\017\ \021\027\017 )Tj 0.192 Tw T* (\(U-\021\036\f\021\), \007\035\016 \024\023\030\036\007\036\035\036\027\017\ \016 \022\026\004\036\f\021\r\036\027\027\t\b \023\030\017\027\026\022\024\ \r )Tj 0.078 Tw 0 -1.218 TD [(\(\023\024\035, \023\024\f\035\036\024\023\036\030\026\006\017\024\027\027\ \t\036 )0.5(\024\f\035\024\032\027\036\027\017\016, \030\036\006\017\007\017\r\) \017\ \f)]TJ 0 Tw (-)Tj -0.015 Tw 0 -1.218 TD (\023\024\035\034\024\r\026\035\f\016 \b\017-\022\r\026\007\030\026\021 \ \(\233)Tj 0 Tw 5.83 0 0 5.83 414.0237 642.9138 Tm (2)Tj -0.015 Tw 10 0 0 10 416.9387 639.5838 Tm (\) \215\017\030\f\024\027\026. \200\f\036 \017\031\004\026\036\n\t\036 \ )Tj 0.402 Tw -11.363 -1.218 Td [(\022\024\035\017\004\036\f\021\r\036\027\027\t\036 )0.5(\023\024\022\026\026\021\036\035\017 \(\r\024\030\026\f\021, \222\204\230\ , \r\030\036\n\016 )]TJ -0.035 Tw T* (\024\023\036\030\026\006\017\017, \r\030\036\n\016 \035\036\004\036\027\017\ \016 \r)Tj /Span<>> BDC ( )Tj EMC (\f\021\026\006\017\024\027\026\030\036\) \017\n\036\035\017 \004\017\f\035\ \024)Tj 0 Tw (-)Tj -0.054 Tw T* [(\r\t\036 )0.5(\030\026\f\023\030\036\007\036\035\036\027\017\016 )0.6(\024\021\035\017\004\027\t\036 )0.6(\024\021 )0.5(\027\024\030\n\026\035\034\027\024\020\024 )0.5(\030\026\f\023\030\036)]TJ 0 Tw (-)Tj 0.27 Tw T* (\007\036\035\036\027\017\016. \215\024\220\021\024\n\031 \023\026\030\026\ \n\036\021\030 \006\036\027\021\030\026 \030\026\f\023\030\036\007\036\035\ \036\027\017\016 )Tj 0.106 Tw T* (\030\026\f\f\004\017\021\t\r\026\035\017 \r)Tj /Span<>> BDC ( )Tj EMC (\r\017\007\036 \027\026\004\036\027\017\005 \n\036\007\017\026\027\t \017\ )Tj /Span<>> BDC ( )Tj EMC (\007\024\023\024\035\027\017)Tj 0 Tw (-)Tj 0.111 Tw T* (\021\036\035\034\027\024 \023\036\030\r\024\005 \017)Tj /Span<>> BDC ( )Tj EMC (\021\030\036\021\034\036\005 \022\r\026\030\021\017\035\017 \r)Tj /Span<>> BDC ( )Tj EMC (\235\024\030\n\026\021\036)Tj /Span<>> BDC ( )Tj EMC (\227 \204\036 )Tj 0 Tw T* (\(Q)Tj 5.83 0 0 5.83 312.567 552.3378 Tm (1)Tj 0.153 Tw 10 0 0 10 315.482 554.3378 Tm (; Q)Tj 0 Tw 5.83 0 0 5.83 328.0108 552.3378 Tm (3)Tj 0.153 Tw 10 0 0 10 330.9258 554.3378 Tm (\). \215\024\030\024\020\024\r\t\n \022\030\017\021\036\030\017\036\n \f\ \021\026\021\017\f\021\017\004\036\f\022\024\005 \027\026)Tj 0 Tw (-)Tj 0.015 Tw -2.762 -1.218 Td (\004\017\n\024\f\021\017 \023\030\017\027\016\021\024 \027\026\004\036\027\ \017\036 )Tj /T1_1 1 Tf 0 Tw (p)Tj /T1_0 1 Tf 0.015 Tw /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (0,05. \215\030\024\r\036\007\036\027\027\024\036 \017\f)Tj 0 Tw (-)Tj 0.171 Tw T* (\f\035\036\007\024\r\026\027\017\036 \f\024\024\021\r\036\021\f\021\r\031\ \036\021 \f\021\026\027\007\026\030\021\026\n \216\036\035\034\f\017\027\ \022\f\022\024\005 )Tj 0.241 Tw T* [(\007\036\022\035\026\030\026\006\017\017, \024\007\024\002\030\036\027\024\ \035\024\022\026\035\034\027\t\n )0.5(\220\021\017\004\036\f\022\017\n \022\024\n\017)]TJ 0 Tw (-)Tj 0.144 Tw T* (\021\036\021\024\n \206\211\207\003 \253\203\026\031\004\027\024-\017\f\f\ \035\036\007\024\r\026\021\036\035\034\f\022\017\005 \017\027\f\021\017\021\ \031\021)Tj /Span<>> BDC ( )Tj EMC (\227 )Tj 0.017 Tw T* (\025\030\026\036\r\026\016 \022\035\017\027\017\004\036\f\022\026\016 \002\ \024\035\034\027\017\006\026 \2251 \017\n\036\027\017 \023\030\024\235\036\ \f\f\024)Tj 0 Tw (-)Tj 0.042 Tw T* (\030\026 \221.\200.\210\004\026\023\024\r\f\022\024\020\024\273 \204\017\ \027\017\f\021\036\030\f\021\r\026 \007\030\026\r\024\024\b\030\026\027\ \036\027\017\016 )Tj -0.061 Tw T* (\025\030\026\f\027\024\007\026\030\f\022\024\020\024 \022\030\026\016, \023\ \030\024\021\024\022\024\035 \225145 \024\021 24.02.2022 \020. )Tj -0.037 Tw T* [(\200\f\036 \035\017\006\026, )0.5(\r\024\001\036\007\001\017\036 \r)]TJ /Span<>> BDC ( )Tj EMC 9.116 0 Td [(\017\f\f\035\036\007\024\r\026\027\017\036, )0.5(\023\024\007\023\017\f\026\035\017 \023\017\f\034)]TJ 0 Tw (-)Tj -9.116 -1.218 Td (\n\036\027\027\024\036 \017\027\235\024\030\n\017\030\024\r\026\027\027\024\ \036 \007\024\002\030\024\r\024\035\034\027\024\036 \f\024\020\035\026\f\ \017\036.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 303.3769 408.2018 Tm [(\033\034\020)21(\223)50(\r\241)46(\024)52(\026)45(\024\232)]TJ 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0 Tc 0.253 Tw 10 0 0 10 303.3071 383.8458 Tm [(\215\030\017 \026\027\026\035\017\036 \030\036\031\035\034\021\026\021\ \024\r )0.5(\035\036\004\036\027\017\016 )0.5(\023\026\006\017\036\027\021\024\r )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC (\215\025 )Tj 0.315 Tw T* (\020\030\031\023\023\t \002\t\035\017 \024\007\027\024\030\024\007\027\t\ \036 \023\024)Tj /Span<>> BDC ( )Tj EMC (\023\024\035\031, \r\024\030\026\f\021\031, \222\204\230 )Tj 0 Tw T* (\()Tj /T1_1 1 Tf (p)Tj /T1_0 1 Tf /Span<>> BDC ( )Tj EMC (>)Tj /Span<>> BDC ( )Tj EMC (0,05\), \(\230\026\002\035.)Tj /Span<>> BDC ( )Tj EMC (1\).)Tj 0.183 Tw T* (\200\030\036\n\016 \024\023\036\030\026\006\017\017 \r)Tj /Span<>> BDC ( )Tj EMC (\024\f\027\024\r\027\024\005 \020\030\031\023\023\036 \f\024\f\021\026\r\ \017\035\024 35,0 )Tj -0.04 Tw T* (\(35,0; 40,0\) \n\017\027\031\021, \026)Tj /Span<>> BDC ( )Tj EMC (\r \022\024\027\021\030\024\035\034\027\024\005)Tj /Span<>> BDC ( )Tj EMC (\227 30,0 \(30,0; 35,0\) )Tj -0.026 Tw T* [(\n\017\027\031\021 )0.6(\(\030)]TJ /Span<>> BDC ( )Tj EMC 3.71 0 Td (<)Tj /Span<>> BDC ( )Tj EMC 0.706 0 Td [(0,001\), )0.5(\004\021\024 )0.5(\f\r\016\026\027\024 )0.6(\f)]TJ /Span<>> BDC ( )Tj EMC 8.637 0 Td [(\002\024\035\036\036 )0.5(\021\030\031\007\024\036\n\022\024\005 )0.6(\n\036)]TJ 0 Tw (-)Tj 0.03 Tw -13.053 -1.218 Td (\021\024\007\017\022\024\005 \024\023\036\030\026\006\017\017 \r)Tj /Span<>> BDC ( )Tj EMC (\024\f\027\024\r\027\024\005 \020\030\031\023\023\036. \216\024\021\016 \ \030\026\035\017\004\017\016 )Tj 0.077 Tw T* (\007\024\f\021\017\020\035\017 \f\021\026\021\017\f\021\017\004\036\f\022\ \024\005 \007\024\f\021\024\r\036\030\027\024\f\021\017, \022\035\017\027\ \017\004\036\f\022\017 )Tj 0.07 Tw T* (\031\007\035\017\027\036\027\017\036 \r\030\036\n\036\027\017 \024\023\036\ \030\026\006\017\017 \027\026)Tj /Span<>> BDC ( )Tj EMC (\244 5 \n\017\027. \023\030\026\022\021\017\004\036)Tj 0 Tw (-)Tj T* (\f\022\024\020\024 \027\026\004\036\027\017\016 \027\036 \017\n\036\035\ \026.)Tj 0.166 Tw T* [(\200\030\036\n\016 \035\036\004\036\027\017\016 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 7.608 0 Td [(\f\021\026\006\017\024\027\026\030\036 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC [(\022\024\027\021\030\024\035\034\027\024\005 )0.5(\020\030\031\023\023\036 )]TJ -0.008 Tw -7.608 -1.218 Td (\022\024\035\036\002\026\035\024\f\034 \r)Tj /Span<>> BDC ( )Tj EMC (75% \f\035\031\004\026\036\r \024\021 6,0 \007\024)Tj /Span<>> BDC ( )Tj EMC (8,0 \007\027\036\005, \r)Tj /Span<>> BDC ( )Tj EMC (\024\f\027\024\r)Tj 0 Tw (-)Tj T* (\027\024\005)Tj /Span<>> BDC ( )Tj EMC (\227 \024\021 6,0 \007\024)Tj /Span<>> BDC ( )Tj EMC (7,0.)Tj 0.08 Tw T* (\200 \024\f\027\024\r\027\024\005 \020\030\031\023\023\036 \002\t\035\024\ \r\t\016\r\035\036\027\024 2 \024\f\035\024\032\027\036\027\017\016)Tj /Span<>> BDC ( )Tj EMC (\227 )Tj 0.325 Tw T* (4% \(1 \027\026\020\027\024\036\027\017\036 \030\026\027\t \017)Tj /Span<>> BDC ( )Tj EMC (\024\007\027\026 \027\036\f\024\f\021\024\016\021\036\035\034\027\024\f\021\ \034 )Tj 0.269 Tw T* (\001\r\024\r\). \200)Tj /Span<>> BDC ( )Tj EMC (\022\024\027\021\030\024\035\034\027\024\005 \020\030\031\023\023\036 \004\ \026\f\021\024\021\026 \024\f\035\024\032\027\036\027\017\005 )Tj 0.159 Tw T* (\002\t\035\026 \026\n\036\021\027\024 \r\t\001\036, \021\026\022 \002\t\ \035\024 \r\t\016\r\035\036\027\024 10 \(20,0%\) )Tj -0.06 Tw T* (\024\f\035\024\032\027\036\027\017\005: \027\036\f\024\f\021\024\016\021\ \036\035\034\027\024\f\021\034 \001\r\024\r)Tj /Span<>> BDC ( )Tj EMC (\227 4, \027\026\020\027\024\036\027\017\036 )Tj 0.055 Tw T* (\030\026\027\t)Tj /Span<>> BDC ( )Tj EMC (\227 3, \027\036\022\030\024 \022\024\032\027\t\b \035\024\f\022\031\021\ \024\r)Tj /Span<>> BDC ( )Tj EMC (\227 3 \(p)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,028\). )Tj 0.387 Tw T* (\223\026\f\021\024\021\026 \030\036\006\017\007\017\r\024\r \r)Tj /Span<>> BDC ( )Tj EMC (\024\f\027\024\r\027\024\005 \020\030\031\023\023\036 \f\024\f\021\026\r\ \017\035\026 )Tj 0.015 Tw T* (1)Tj /Span<>> BDC ( )Tj EMC [(\(2,0%\) \f\035\031\004\026\005, )0.5(\026)]TJ /Span<>> BDC ( )Tj EMC (\r \022\024\027\021\030\024\035\034\027\024\005 \020\030\031\023\023\036\ )Tj /Span<>> BDC ( )Tj EMC 16.931 0 Td (\227 5)Tj /Span<>> BDC ( )Tj EMC (\(10,0%\) )Tj 0 Tw -16.931 -1.218 Td (\()Tj /T1_1 1 Tf (p)Tj /T1_0 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,204\), \(\230\026\002\035.)Tj /Span<>> BDC ( )Tj EMC (2\).)Tj ET q 70.866 374.125 221.102 240.013 re W n q /GS0 gs 221.1023475 0 0 240.0676995 70.8661504 374.0704115 cm /Im0 Do Q Q BT 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 9 0 0 9 70.8661 363.3257 Tm (\022\t\217\210\b\002\220 4.)Tj 0 0 0 1 k /GS1 gs /T1_1 1 Tf ( \214\001\025\024\026\002 \002\202\n\030\025\006\021\026\002 \f\026\t\203\ \025\002)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0 -1.2 TD [(F)-16(igure 4.)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf [( Sutured g)13(luteal fascia)]TJ ET q 70.866 100.996 221.102 241.025 re W n q /GS0 gs 221.1023475 0 0 241.0279729 70.8661504 100.9937445 cm /Im1 Do Q Q BT 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 9 0 0 9 70.8661 90.1959 Tm (\022\t\217\210\b\002\220 5.)Tj 0 0 0 1 k /GS1 gs /T1_1 1 Tf ( \255\013\n\021\006\026\024\031\023\022\021\020\017 \027\025\030 \205\001\ \025\024\n\017 \032\026\021\020)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf T* [(F)-16(igure 5.)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf [( The \233nal vie)10.1(w of the sutured w)12.2(ound)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\033\030\031\030\213\b)-20.9(\035\231\213\233\t \021\032)50(\b)42(\032\231\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj -51.938 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 23, \023\0221)69(, 202)69(4)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 23, \023\0221)69(, 202)69(4)]TJ /T1_5 1 Tf 25 0 0 25 20.7527 56.0378 Tm (132)Tj ET endstream endobj 996 0 obj <>stream Adobed     '$''''$25552;;;;;;;;;;   ####''',,,   ####''',,,   ####''',,,""  !1AQa"q2#Br $%&'()*3456789:CDEFGHIJRSTUVWXYZbcdefghijstuvwxyzs!1AQaq"2Bb #$%&'(3)*456789:CDEFGHIJRSTUVWXYZcdefghijrstuvwxyz?)653NAP,1 ,|7HtscTx="Zj$ZTb4i#+` @oc\VL3­Skӡ-8C6p:![ tC ,l+qQ5OLKo\^>2k)qh ;!V֨@sm c"?)u8kZc&rVU"PtW 1٫;kk_"zx-q)b͇ep) It{^K\v=8{<7.۸wZèq-I N*Z 꺥GI9.uKLl;խAElC[wgjAxHNwsp@iDkrCq1ItL~2+J[$Xڐ;A@ (8qE\zT9+&I e!2G@SsvH"MEUM쀹L&|G%3c~6$e>ǰ64:-`fsL e(a ظ\nV@"ˌٶL h ^@ԆBW4D'ZX{;,)۾EԽ#zOiAv6 .PE"E˃q[%X&aj ab@v%l$6<5]wiQ}q< Od· &q|)؅#/)yzxڍq<Ks!1^j 8sCW`k[m;';v)f#:eqZ;szt15P|i&8 aG1ww/ƨ`1HAesMh]utD:P6usW;6^{[0A'a.8y;gw7wsEAB-O@N,à@owl޻g`b=v^r$=ox֭O>5L? KI 7hHR{Ov6dø{MV dպKCID8%w1L};R6'Ǽ?0ֳA hߊlT8-mAkFy{MpM[ `•U0#(۳ahIh~;DO/ ̒mBޓhg0o]g5&|껆Q_Qyh29&]577j84p${J9Nx)b0Xd'p[&0p)p¯ǵV/;:R#3D2CA#++vo)1Sy Of> zͤ'fIiZ)v` Ff&.j׸z+1ܽF݌8f.)SFB `\uwR4J8'Wj;KHG|Dž G{ςNid \j=͠bg;sbX\4DHZl3WG@>=PQ~˜I:G'oTal1amX.hq<T཮)«$2Ϻc0vz ;>r㽎5]baZmfհsz QjGDuVƔP;Z$r:7Uik|K0KphV<jbF7UpJb?1+}<>qaZ` z&*YO&K:jfS{^gIT'gl, Zi1TcG|h,ڰ"GXOkdHV\_ø@j8FeBwQn Tcc hc c)9w j7s0Z ^๤p k| 8vW B8g 3,n;9U|#g8c *mW8lU1JCe"I#Lm@]+{,{ hi .baks d3D[w3fu\טo=v\L1bxбr XM2Dz+4 hFx zK YHOQ$S*pRA0) |"$α-m"A+*wT'E5*ggnEJ4MDL&%><2 kytęn\KĢ6qIl;_ Zi asXVkr735'ǹp=Ia 7LqollU1eaxZ"\4.G8̧Q5f@oW bܔ\dU SiJlRM^edbJ5Iquʄ!#`h&-%m+ JBfn<"藅*P!. ]&"gz%Bakt;B 䂦P!(II#D5(B01JJڱ;B6$q qp09 3*%T,. lhmLC|{DQNT.|*!ch1eQG  H9Qd!DLŖgn,FB,brJm_T(BJ% &{[)2!y*B^!65 7 ҥʭR6)0J):aoF(ң t-S<85,-8/y+@$25VK4P fs%agMc mڰ>"d|=K;[9iǛ_5pZ^E"C}gGptn]В*=h[GXb?hsb=N̈́ |%;d#s#Pfg}f[@Ё+%RWj8Cάq@g<7zMrllPrK2 !9 $Df!Gop$HR,50! N#Z"Sm!# ;P!%Z^aB^݉pj\۴JxuJ[\XaR҄! kH-m&ɶZrNr 2% 8NHf2PP!C]f P!Yf$7PBB02BB$+$@$UBJә$EHB<'t*B^5 [`ynEb1=ыfk\uDIٕX!qF׌&X`[ߙu3XR3IOC`pN S¤ L3سWa@@żX&J> Yk%cK9{pi 2`/<DaMC[É kkZ|Zav&#kG>uYSr\K̢֜71+g5 p^ %eJn;^)<0 }.!I2+IN5&ZfaV5Bl!PˁIF :nlX6!pvipޘ&] B!mYd +!Xm` QU B\ X)Ф h$sQ%BIXf(CD"B@@mb!CmɺBO: (Bg|a&K".B!#Zވ7&1 L Bxïmp&*! Id$e@]t) CwBTw:@KRTs$S&B D6eEf6K'`lD "$B\gbJ.tB[ǼbCq6 -GAͺ\j)dPEVG*٦zY0r@_ K&];+[$u;Zن\0@\ͳ&96.k[GY D 3A[ s+\GK#-՛xR51\`R=v%k%7&D.(Aakg A0A(Bd@P ]s@B" {vdH$JB`m(f4 ܎gT!B0ވ2\pő6$g:Bymp)'#D$B'hἠ%j!Rwd5 Ya! !nhA;S*oTuσT PJPީQ>e+@NҘ̼Bl\HMΆv9&rBw @ZJT! B8X (B'D/ f% 9BMk]uL.٢Nd!AFKcDmі s!BaJ6p؅!B dom.?dlEB2GU6AS*!@\l9ąsy#4"@"F,Buй,y.yĻ$ج.IaJ2#BqBݢ*;I-M*ќʎD!RH=B{tf]V:7R2!N5-?3wNє+׽W;LuTTuσT ЬUUNF65X`J-B %˃LWwsG]`ơHRɸ!N $]gD-d)ʄ! &xDȐ֞*B"y26Ν>=,Χ4-P!>#3|B3B'FϚBC׿4E)&Gqsbބ! ك ihw \! 3(TBt n4M"piHr3Q6B4Z@fD&̴(Bŝ 3Òi9dg#7*3V(B" 9@+0r 85wŇnӥ!H$]o6-zjϝU,8C%>*m Fr@6&c< eKw{[e^k҂!Xo XBlygnmiN]f9g'W0ݛ0.x9JIWlI`{LSCpN&lzwm18 .u.N|!+wsXԁ ji0P5_=D6G+THAGySI>j_ec@#xӏb߹ a.cD; m=;+ " ϤrNcA鮹䙎v;04 s_HQ4i0ݔ7™iR3;l YdQT!K @(P! o6#cU% #mUh>­§Bo}ABuUVn".m$Z@J^`! !'pDX)@(B3(SRXXB\NPCod0љBB{.7"Bsn³Rb(BHJ\BΨ]NHRIBdM9k k #:T W#%6Ze|HB;$:ȅ !4Am=<"P!G{MAtRwd}12*C!Cu;:T.lI{ppْk䈔+! 2 : sI2?R7m3V  S$!B$lmk[JC0պؒރc[+:Q9h!=Ga;)mA"w$Shv,cZӪLr*WB.aX^5Wdglcq.հb\d&L@.Nb ު&͗;Ě3+;jF,dĊ{SG8(bo(Ьzk}JT8wI}.50tb ?)q`&LPB"Ild(2JA # DBeuĔ 2l )BXmlR.5XE!H(B$` fBbB !D^ "'4q(P!Kg5alA+F“ ( eB6HE腯,uő9̋nBt!FmYh(PUM!`&3%ŪmB+^!Z%NYBک49en.%SegOBPUbPB=%4$.2Vy57BhIňȤ`!BRy!m B eBe& ZKH!Mx4jEa!6trĸ*MdlD)BәTl2{)c%J$!Bz⎡6H2kZz)`>`B `7ڟmz&#qh2 @(A-6BQ{y sO2\uA(݆qB!M$jV1/k4pEtUB=$$<%{&V5D-B/M50'LIʌ(\/RODkVl؏0O!4B51]/xhN>%?a_V 8,}Z I;p,bdr ӻg!6عg;> U1zvf`:L jf 0 +zsdD471rA'UwC){r\˜.ՋcuS໸fl6| qؘX %سěx~YGRhi@tJ;[PKS%1S0`4Lp =娒;n1dWƘ`^ݎ ,s;t 1ؼhؘaqeNmu }A++$! D ӔT,q[nB6쑈 Sb|D$\e`P!,buFWB@ڍ" yB%BœR!08` t aT!LmoKj(PEiP8?c@U[Mf93QGX+O`n cR i(&-x=X #]Vs֒ð\ NC k2Ji\q8- Զ!hoWs^υ j #ARXNLr]sJ6g+pDDu\(Ӎpi;4x&{ݺe G!B~;'Ae;-aD*!Yk5Š3NUBn(eaHB3JXE%.zB,Kx%r!BH.9(6TB%BPAE}!B` XV0 !A#IT(B"!$LjP!IthR! 7Z 1PUʥB/BN>ƒd!]+T805Msd/d&lB| &$[51(-(B Ͷ"gjhуB'1!VHKeBb @$H2BD!KQA"ӚR{Se`!=1lY敳*! uI"z5FbA!B:"J :Tђ &3dئId$-(WBOdm\Fe>\ "6JyܡL! !6etB۝# ͓Uj tg Uۧ0Bօǯ"lB"y2!׍YMG#,q&m y˦G7g[ZJ{` k;gq0Z[\b$w'[zw#a{UxL yUT5Ĥ5 pv!'Fm8`$'J!BX.#@ddJY!Kr(k MozSFe(B3 ; VW:u!U !B{cH]n j!\ n6]$X-pDnS#T!D S(ᦕӢ* B1 t%1 @(j y@+4%c75kŮPV!Bzp-/kF#d.s^ J%c) eO}ꛭЍ>‚$ST+5UY#$h+b!Y8B .#b!B˥!u=gdmq-4SP!4x9,|209jQ푱Mn'D!J ). QB<<&9 M$Vj&_$ۻ%6Ԓ@2ȅ3(Bk `p(]LS! Skz\<Dv,P!E#D)j1U|4B BAé!ڠX`Uըpvd2LH܅0:*-&)!]U3jMѨtPOY!֞GIERVxauu0ᜠ޵xZfaxoR9I1*8ؖP1y16T q."9ZD? T[aDkָwJl#Ť { $g(ws\0) )?/rWn[1qF?DLJI\~gD)nQ+sflJzpgSmNӐ0[^#ҕuc0K1W22Dn\~Kx˭w{in6.L-2xϜtN0Ţ M8"ecbgbn*SuU#r'|)(q'rxP! TV:A4TBCN};, !BpJv*B8@B'[aB!'4RC$!$DJ,qY D+! rH@aud B F$G҅R!BRT*!B!a! 2 QBg}]hX~jaPMMPU#rB2a[B$bH*aBeae#RBa2ȲP0BZ!B ΁m1ܞ!4 ؂ !Bf汹$s0‰Bp`dOh(A)B&85e$䝁d态t!@9!q \(ʛDB6܄itU76بG! =D`.E8!2 ҄! 1v2LI$ԦA'IPiBͥ -Jnc *X>5s}cX5tmB1KH1Y-F,pLijը U*L貜tO ¸;' `u'$gR FTc[I;pdH]Ϲk|2O7q]Ƕ LE9/;f3A!k4:;z ;c612NHڞ xo gЛ5Pፚ޳\9#ZvNjld^YqIɿ .nIIA;~kne^_"a:ڸ?Bi4#8FEF|II.$$$P+&43"ldA}©*ބ!L ca1扲 !O0]dXoD\P! @2,4 Ӡ…B! LёNStӄ)iJ'bQk qBPHkHBeBNVR!.Hd$kL@Q!BVTv("홡Ҧ B"%1Hࠪ8ABp:# $ ,c\LWZS*BoCKT UJu@`mD@X@ RB\q0*BB\P5] f+%e e&BN6BIH&T(!Ja7R3KTHX9+ UB1S `d!Ba4kAH^f"r%J,q Lx[ kw)R! A'^Ep"TD!MrGI!`32PTJ&9o&5rShM>2HBȪ2^ہuad)ZBܦIk8 @!R\:a) znt;eq*t}`89\ԙ0F5aL+aὯmA/D?;'2%7]p- ..6bc-}. qTk[ -ߋpv3 ;2N]-kir\u,K+en6KD@ע8u@s:\Gg*dIC0 ➪&̪HBLU=JͽF7mE$B0 D !( -*(BFӢebqg!NoӲ!2 p6Iu BqNlSe! NB^bP}Gt BP=لDM!X!B s HQlFYʖ X$L6UB8&LND@0 !BE!B "e9@L(R!#YRHn98! ԤH B4JGJv0t!Me v!oJ򣺻Z`[(BOYJt>K: ! fJO*8 (5B5Q@h41_5HB.$MTN3)VBlJFfضjx-% Pd9ֱǔz mAwe^?I@Od +a:;a;1sFj`.Gjqa01[]  A<٭ڔcK-C7i{YN%KNI_4hfBSNxh$99e+!c+ _6+F-H!tf1"!`!E'0-(ABz&@7Q5 B`QJl`RP!^I?Z>­ETPşDnBuUZa`Mfi@ f uB s ҡBnB@M#A\0&*U!!24?.Mh7E!E 44Ϋ!#Q2!DJ{YtBa S* w\EܤBXm%]2RJ,$dӟ):n*!4: |Ip0bB!B8B0mj32srZ!MIÙBIi_M+Ӵ&_mZ,c;s ) 7Mi;P]k<ht ے7qN dV_Z  '׿[m,c1[ZA =ܦb"]9g5xWO" WvW`befZnan6'i)fH7PhTdhpGa'TcjJ! tF !2lyj!B BPް8,AHR!mѵ :t_+M!Hm)9$ !B1U`M4HFb !cMI$kp B(Bo(!J!!CصD tM!BWXJiU!J d0.A(BJͥ` t@B ,7T}h˨??h̕?ZsT Pa \'%vj Љ"聶[0BLeu(BBH B!B"ɑN t2١HB s9)R! I;R3 HJ6Qd!BB # n*P!#i',3MUO<<(i&V) _8_Sœ`O Lě&6ad+ of Je mǒ7 =BE UvU*h'D39]Cu{D ?̉y޷pRW?96ɆEcp8q~vz缔 T['nS10Ә)6*WEa5L>wܞH2d R(RH- Z D釉=P!+c9F colN!J,d#l0I0NjT!B\F-usvDb4B rGwM P!] MSnΠu!17H L2qFHUBt$k$4JFDm(P!p QJ!ТP! JnXehABGZ ?3­U/M (&+WfL!3؀^F)@ Y./0Bm) &A2ImDBfuJ\J9P!@%B!D]k k7Xe J$pM^@(Bkt8,Z %aq9!K1b2!8lD + !B \Y)9:eBݐ<-Ӗ2!)@FI (R! ʍPO7eM(Rqی]0qBVXQT+5LԿ:Xb %h®'0t &DSȦ؃E R&P5\rp[ vy)-çT4'LFx!r~Ilp#ҋbp2P; /uP<šX;kX@XE##b;"%HUUPB:n:reLJq !  $-O26(R !drIL' ڐ@6Ś+e`! Vtg!+jcr%J' Ⱥ"\r#LFeUBM.JVt*B6䡠 bT*BS@Д)BA{u6((B$J@.!%!KgYT~ mS*ЩzдڧPl!ibihPJ䑃-v%SW^`!:w$"rH \IBB٤pf"Pܐ!n-REJ!ndMqd."lmB!.8) 9䜐IBD,ށD BGlJ H\Id!I7M=8IEU7Ф!GZE94B* !+{+ R  !B8MhrB PLTd aphYh}2Qꉕ"eb:VͭM& &0*fF&2NsfW z)lӚGx.öar$f8zTa Ct]ek܌Pti]ZIV4ͣUWB"Ձ:nXbk!=| ڃTDj7)c0kUꐡXN@&+0P!>׍Ql2 B!BwU^N6M %HRB?D9ERTB F։F B BH8!0I( BqJdZBT!J Cd,. !i%`J!B ((P! D!Qւ&lU$~49! \-{K\{q,R.aKR^`!8߁7ffszg[گOQqm! Un83 *0PDRɝvz( endstream endobj 997 0 obj <>stream Adobed     '$''''$25552;;;;;;;;;;   ####''',,,   ####''',,,   ####''',,,""  !1AQa"q2BC #$%&'()*3456789:DEFGHIJRSTUVWXYZbcdefghijrstuvwxyz Z'!1AQa"q2R#3Bb $%&'()*456789:CDEFGHIJSTUVWXYZcdefghijrstuvwxyz?PP% &*ZH|+4Ȋ a}\{ ~,, 5N:ֈ*c64Hk+|> E7; Ȓ;bVkc]r;q8C 0[A&pz\A"5d$Rr?I n'pC|n7ah`yKAT./qa^ep_O8HJ%xl3o~죋0\d&g39.5$OTY۾HfwK_8·XDԩ&tϙͣB1 8s\Ma^8pLɩ &_ꟁ;iPZ8Dꎻ]]l.6!O@^\!55+ds0Z_֍Mտ,0/-?3b֊c;ˉ+t9@]*;+[;)E[JD(xwUL$y.PBiii+[L5XIP,24etCHzRR{#:eVn."D/R,%tEQ %aՔbVl! S3]9sOs@XA(Bo)Z!JL2d9B.NmH%ͣY!Gvh ӋY!qt:r"!#]-R3%zP! Os$"dbB$;8ō@x^鸽H\NаNt,VWwJًFf 08#m'aOFT3ނѪ!LӚN 5D)Bh/K$AE pBBtF-I0!@,`VX!A41ARp!lB.VӲ IZjR+mٳ% Qd^$ WǖU ڢH+QخFjѽ"T*/?7ś=PBvn|v9h{09ㄱ^IDW6Ψ;8т %+<<w,pu; x}Z&8xhxKerN֡2к, M-bK q \J ֈX7N B&tNkta "Bޗ<4L)@{̡BAнQ0^-%eBZrJ !: BL7X+(Bi@.pxjs6`QBk6 أ4+xoRٗrZF^3BRhu$8LUrt#SiT'@ѡ&2NI ]N I+e +ZO\&Iʨ0ZMw@dd/Ch{B"PiR%JIJp\1%MRk-4+{dEoR4ܽgN >yTBqk&o&Yk"z^`$zx6ux#l\Gc8ɶXaac?+ $cKW=guqoB>zcqN}Dt Rk\%Zvm/pEnQ>q=h+Һզc87<[i;BWP4vI^]eb܈SeZaY; ٣Ssj0dٛIDB'Nz PBBB%x(D! @9'|3`7H檟b>AV|N/{f q ~-79zB~ pl1[<,ң"L!]ԅjlV=YnHl3?1ԐFp/GPҢ#ęCw4RJEI3;n $MthsI^kj HԭSAD5wM ޣӧRL-#3bch^SM5\?>f:lym!x/.s qut;gٟUጼB.6{oa -kqel6 Cg4[ Q'm&񮻖9pY`);ʗW|1OOZP KXWr(hHXBQ=^jQVL:eB$K:MԋuN-rRB@H=v=vYB#,j og} /Lh̄:uhHn'\&!%u1c1 A*g;T!OilTm>ųwsA =m `V"V`Sv3fTH"X/' Nr9GRYnQ}hZV&9ݛZ#$Ā p! 1uX!Ov)H♏zA1+`B. :FB Uc. 4^QF u姦3z4P+B2- dlAfH*KvgT@YBU,{8k ]HseZ64C d0b͐/Sp1.$+.7ZoWa1٢QNiӉ܀βª!zBIr ,'hO!88! dP&c%QB@$$&+!B&9L, !OqISZt(B.'FhbawL*DR6 *^<'d{\4*YNKmUinˮև̻6B؄Txe?3oyEbqYXÅu? 1]y/ Æ[gN<B5m*W8`Ӣ0^u?g)CS^zXm "s^ 9 6Cz{ձ/ aa{+l^b7p-y<ɓmaY:Ќ1Vn4֫]\0K,G`9Q5g<3eqC6Zw'V5 /gTo-a^;1]$&S0 XR^jqVI&JOךw!BD8w#lzPBԧr :qI\OPԥ!Ӵ;eَ[%FMÐ͂#cl#!smU8yzI'9VWuS1nҬ ɄNU'p Ƽ4Y ~t lhwvZAnPJYբ &L^uW97+Vb;1ZHnI5 $!^$ BS\,r)]n ٴE|0`Ou!e.\ixHJ5 OLCyA@h6P3~ Ov{`a7uŘ,!NFMz$sR4șR!x@FzM|3igڢm:U虲4٩h7=bBJ)Q]< IMr !0+[z H!B]tVS1rBBaіrƁ8nh! Cq NA YB $J %@(B߈ݥ 播l@SmH$&Ux[ *AH7I/uX% ukUAead fiV&CAS^-uA`\lDEeB.DOY!O &"8X(B@p5cI yTH##8K67|Z X!O b[? !^#49) DB''!(PBB@J&RX %BBsHa"Q!Bg$!׶i&Rf0B * gVmG4 ZFQ+23Okض# n!kn%!D31N  1{#3zr6a]gbx&);`@ծ4 ZNHViVdUd±3C̍MקՎާSx ._ gbbu+m'$h]&6h @v,hQXB '1dB ' &>hN&Q.dVlB#뎖IDtyrCfNGtFqu5+$BB>#4 WXB'@)KR9dJ(aewtrp  u%AV5YBa7M&9q9Ί@QBfɰN 6TP! IHZ[ױ8trġBd.nd6e׃1貥(BILy )0MP! kL'=s/# BZ".xUz{E]Dz4w6EZjmE*nV LO>?Fk뗆љm+ o5\FwwwZhsSyz{E,)/(Vkmbx鳽Y Ϊ(!s]0 EcD!G.%Q pP/ '5e̬!Y0 9ad0 Z`D!xDA&.eEBLQq(XBAmf/$iRB" 8$:eB"O0;rp&V!B=ʓpq9,P!͒ QPB"drI7B'Y4(!P:$ɢzoѺ$mμHmm.tsf'j žw fqWNw=Jlq8m+-7, "7N!w6F]s66.ւR^Vn^Y^ ~gmH1{J@M+Ehv3Fx\GwOJblP+*(B'D:oڔBJqh%䌺*ք! l~C0 ) 3]4{`7.N+n(;j$`$L(TBY!!J@B[PrEk*AB#op9`#捬ou2:$QY!MKd42eY!M2-IޖEX(J/_!tғiXB͓LdBܐ&!0L$HL g̴I9BBRq   .9U-錈ݽDkըM u&)TV*KcPpˉ_LJ:AD`.:: U:r}i'LHf@' A}cx;Z*KD٠۹K7^K:)pPL[eʵ&My"W~\MHI[쌈] u5Ls|wI*siY.ä4B Ѡ0pXIU,5+ Vb :gJKheZM輳hdiUUx"l`x/xK6y> qOa0aQN{@:lk lx (]lM"M4@ 2zT1"'b3č".90̎'(3Dd7: S$BPV"shhOa"U!B6'&SCV`aFP!, / ], '$uQ0! ҽd#$HXD!B[)RNJ /\^Sw.nLVmR(;#`.rM̝ud5cVeBQ2Agq+t:4o*HB0պC{1kY:$;> }^]wE.J ! `#f$vtiQuԃtB&ujX!L$͓\:^^.&8޲P!6ZnG鸰]DĠAZMKh!e,Fw^h\:B/]9њiˊ! 0OlZJ# (eBǸMYG{jDkQj[.6!B庱p웑\ـ77=ML-TpiЍ5 p\xΦTR &[M6:KG(U`;UΒzੰޭ9X(L s):&C8V[bXyV$8Iٽ m60s" a<%! o4a~tU5`L";Mv< w.01l4fm:,5AV@$Jd#1!  SDPHsYUF!$g9)/4 ,7:hJ'S@58RBQA$ ޔJ&DKq `$!H7N6&$ A+(B^i%h$JV2@DBsNȯ YP(B8&SnQX$KJg9XX%Ba+70JBF"l0bB2VeBѴ֋(;pH(\B NlDNVK$լ'kw$ߥ6:Bmv{Bά{(o()20ds㼧jҠR@++B YjxpŮf*-Zͬ[V0:\C*9;, Vbl֒ BfRMi0]u8ZQ%A>lMMq .FBL j'ٝ{Zv!JgvGTIX@!Sr\T.\;9^VUBƁ69w{D]:F$J S%' fctǤ#Sqxi` "RG^h1u!A{3 颒h/$h(B[]ZJO]Fyh$B(Ozi&4An/e* rZKNs\W};Anz\ =*llL*fuR8f cڠ/TIkB >5OU;eYU1 ŧ7]Ae )D]JiqDc(FӜ>\rEF ĥy n"``賚TIڄ&Y1>N,s)θn"a5wvU ^"[&U!dUMw:NôܚҤSX *FGR $q^ (B,3N $!Bswk!e9D!Dǹ68ΰ!B@&x8Ta D䲉B:% Ked9BJ"e;D!HNRvkHBliH%beFBNlub #Q*$% ".J!C-RAhS4LBҹRl # *wFD)"27tŮa\` =054œ:d Q$!Bx(u^ݣ*mn>[CaJ;`4 h*)LB UA`2Dz;χ_dR׺MQWszVVA=SbRp pinBI죉HÚ2 VvCF+!BIe.)%$3HMT!K$ ++2! :ZD NE #r!# A  hT5S!ҜuT)$I[Yfv4BtWCrg0Sb |(Bd1(o :!5&:-fK|fi .Y9fצTZlgUuRddr*5]祗52x 4AtD)e$HV40PgG@V5hMI);LOjvzuFB䵌bIج/S5Ub#pC"Rsۈ m Q0% [v$=8t* p0$6hri$gW֔363p1 4LBbpl<4kduK{Hg0[$ѧ@NtY7o\> <3EݕtQue"Qf/!ӄs W1d4uNi.|ՑF%EB('"3D6˳E (BۧIHJBP!J(B.BBI9BQ!BL7Y& (!BԼ"ƶ%<$K!N! .k(Bnd^ كGXwdVP!$+Tv zdzwکMBָAUvSHvG5YB uDeDyTIuo=s!4x (BmI,v q! ͽӈY M!Mh %.ؤ2!eBS-S5,B^&%'İ咓Qs!ԗNe(fc,7X8H;գLXKMH!J!2D MwNcѴ f 6UYYks'Q*ò ʔ͎O3#N9VRYǰRƒA7Z,ËMZ AVDJ&5̧Ws^cAsYo$j! \3#KdMcLޞBw)!No)(ly%(wP!5$V( >#$Fӽ !C,&䥞21`BJP XXBI! 2K?EY!CD H OD! /ZRB&{B)h 1IBֲ@.g$@X(B7N0)lL,P!+dan/8!@ս-9Dpi%!48AHZ ++(BT(eB@I]2=)'F;ILC[e-.! D$Eq  ! I 7cl98;+JBXbe 9@~!%Z:d@+윚S&nc* V!Jc8YG-c<;)+0! \He!! f׀M{LHj!mx$hSH OqՒ,! =Zj<H.WKdT֞",U(B :& œ%1-<5˂Tj s^^Zi(qtuG4Vgd<)I<Bn-kst4 A4 %TpUYK(hْ{)d&{"0CnUBysE!9 !aB)S0g+N#m ĨBhf%J&!NkYܘ0=Fz! Eq9!W QB"tgjB! "d $$݈N )B0◝ MsD0eb "a3bY8@q^eeBܼZuJe=b%FJ&iOSpNkTb !B@I8 2W@NHB@Nz*(B׾ ,kM08O2ISBh R5L,!BJ{z2'4x7 ~d,B١Jő3x69YB ^XQ!L2K"%8ɰuaBQpMa%x,-d- BJ@+΅+!gB7qCJ>]' ( 19dv G nTיu'2ZՐHAtXBZi!FB7hx.:6*#zih 3)5Ҡ:-PE$U."iūM0Z @B j&[7ضRcX(Q; m$HԺ%2D'c܃7"5֝XJ;^m '-m5APuP!DlӃ8Bl44Y TBPө0e)ђP(B8S@TP!9$IN'yI!!? d8f&b)DB&!O4YzZMeB&|rJVaBȜ@"s^sB#2NsBk_"*BY&gB! !KN=VB HbмT!O H 3HXQ''T  pə^(\BV+^RrmRB\O7ii *B'=3].kH#{OlWX'8&d|84+*hBe9orX⅃T!^.2 9:B,! 0I$Fb?Ae#гD!L 8t& AۨSl U6(BBG@y0sM/-%`j%7cqN7 P`B$(n3TT4pZ ,j! C窹T &tAh2윰!UfG)rv:ctFI%,9 XPXP#asI& U^$!B;I$nFh%l;{U9BD)cz̨!B{0@ޘ TѪ!z\r^{& 8@$N*(BLJ7 lF)q9M!DFBoH@ LdoBB&$/(oB&]t#Us"EJ/1A |zd) !Bc# % v,&B!fҞ,Cd(UoBO'$@X-P5Bau{0Q(Br).M^7K%h'/ 9/iHTBx DtJ->V}T)B&SӛI(Ωtk汪B|ׄ%7zʜBBax8 Q*(BKr^١eBMa$B8B26(N%;1 Ym(BpXfP͂$ġ>o jBq9I5mA}LM5d2! a5C7dw!3mXUI{Rj{.>M*,PB%L1d Lay4DJ !\$tjݒ_nhqo=R *{5ELwʍLa[6 0P=Lp̎{_2Ђd%T F.F 6IU' r熒 'l͈[6;Ux&8T=dqQX`::{U5P~ДBlapp{-%r6)9ʑ0 ޢ%ξJL.! Ԝ.{EhކѫlHB#9%y S"N\$!BPH tλLxXB')ȝ0rr@(B̄oB ̣f$B%&FƊl@D ,!^3^^&lVP!xZɯufvK*MP!9Fw^L4]+VTB 7Ncfβ'D!NknD$YlS$B Bdt&-tjWmJ BfycD2sUt!@Ei%<҉/R Yd!CHsIRS6BFJm@$F FVUB2@h3 IBr$IT4ܔ,B JMƉ@"A(B I{6Yid!Cɝ1QKd4(0Gv!u AiΙ&bV@Bi" !9%aLBh9LkoNXIK.$0V'ԁA+\q[cf`MT08]P%E.nX;B%Z^i e{K@ksU}Jzd$u) !BHt ,a:]tJ Bf!NJsramIQ.JBkMRq%;A΀!  (* @0BpI0B^H %z7B!(03M⼲P!axX$&4,eBWIHaLBΉӈ^ !9S_14D !BlB9ӊcYRBY&a7 \&5HUP! 2M,Dp;kŖT0#D!QY_xCv6LGbdrP [cEV!B|hm.m!jYxmpPA-k):n(+[EΠ;}eeǝ HaI)%1Q\ކ&chRT5o&-:mCIʈ%Lؤen85%I11D.]Dڨ>4fUuD¤Q uv.WLU@.]!HdSqRme aD! N2 ) kJ3U@!RiQRGfefD(!:5^](!BEx#$`O2ĬJ' Ҽ1H6( aBІH a(kAJVABz[O2|輄.t!M) fB!I G½1ِ!HZ]`!8Fa!AD!{kD&a+`BɄ`!=UnB@TOw!Bտ8I49!)\BV)&w$D(B RI$[U B%Rk ofV`BpeYl8\@&9%`,T!^ih;Мc9ש9wOp(fJ/Sp3mnbA-(t fP[BnOt_r$fBE!#pԦu$fV@B[!&`uSQ#ltDB`6@'55-Qj33,+p!P1muJ21u*6j@LJ@ \@8/hi*fJP(d7k4Áhbb0tT9]Q b0U^c3={Asٖ?x\kuf:e1N6q,0;lؘSW0D*k]N{=O# Sѹyx.dgo$k*'xNkvV b4K.!$*qT:p݋ <1T2diО{ rySBN#%&r.*BFFK̡BVO$ui p4A0,wuEVBɂ &e5bQf(! 2NN%kK~ (BHh!x@B3o~e^&J!;B$%,!BXܚm2ޘK7YYB{6i1xOݖVl! pe4_$P!!n& $m18.H!z].`J"!8R/b 0 < $ !OzRBɲ$(B&8rClz& u(B%XMگP!zw%t&;6޲B3K 0qO8$< *S7$áS1 ȅuB7YIЄ!8Nlzy&#zq~ D꤂!-9פP)T!AH3dBtnj%H:!M5^A3#MąAcZ]B"eExԺAQj`P!G+5ź^avk8C23UXWa Si\q߽7h11k &Qret/N^+8 #L xI:^S89 P^T Ho\,,ʧԝWG(=2fy^ARiR$ bJm*@N 3`IM`eec0"HɂS)sD3L&(B= R{F L(! sX8VƥUQ!^Rx e!N!nJ(Bۋߊxew)Bi =iePDBb#`fPLBe{ $J%aBC콪W< J')dINc+D!Dmċ,K,!B׼$o#5tf W0B԰:DO2!.l]r7U!K1INKÊ$!Bli'fYR! gr6!Ŋc45)B&Y/RXMSwaIB$/ZLPL^BG- fX fBSu sJXŪhdәBގ),+0ġBcQꈒb9'r+m!CĘۨtu&@AvL!PH&Lo]jH+r&Uؽ81dzi;G:oC, H]1p6]͇hn4*PU3B\DgcOvua#\bXcR(uS 0 raV!AK B1ĉ"Y(!eHthStJ&$e d{]eB)K7e!JHt4 J%Ih)2Y! .TgTۺ<":x3FJO 9us/gq T*\';XM[Fg*O=\)ν@UKU 7`Q4 QlXm8Idě fn/ Lkkմ5\ݠ{U(6zÀ D٭Ul "UX[U8 mQV׎Nĝhn$&}e"d ٨t\5KNaHJ—NH×Vv q" UeB@6Єh˱Je!G( TIE!G -P{ï  e+XZK̄!R=ʊ6--v.0(!R$l pw!H%) O%B2$ KAdR Ma! tސ)@YB&%ˬm!O4ȯ&y@(B 1@B!BN<(!D*^"TaBҢ͑= -ޫNǴ׹ø?.V(wq_+CxGVz#D`,`0FKWpNrijztQzBi*۳m"fVKB$jX!El=F<ij @Ȓ! ^ *8kT9f! $hNqɴ7 !BcͺSFJ9Gf U#T!^cȕ(J!)x/Ho.2B"97J`).=DF $B$nAD"0woYP!YFpTD()DY[BmC4߷\:鸩Vi5} rR'xX/1ڊ^Q"`ʡd8mci]% jn˶7>'&1U&8ңM8RtC1bF71fHBG`NcCSE)Dpba'((,C紇]+7v!sĚ3 =VȺnͶ;hi1QsIrlLL On݊~r*rj5۝u6c7A6uYiPyN x |̐7p~)CT0W'WR ]"g<*SL|ASmUyaH"eHc(Mq4*DBBx#d#@TaBe]{U6TvBJe-sJ';^k$ ' ɈB"D3@Gc j' LJ!O.1'bܲ! ("d!ObLIb2bBJO 2! &^ :21lԁDBcZNB(!LJx^$4a`BӡoV2M D0lviB@TE X0uL&É06pX]^tDШM+Bz#N6A:Upb L.1["o;Wj(?eE# pwy^.z#) wBkLW@ Pdu ZURJu0,=k*9 H6V\4qT5#3B^u#  >״/ݥvZ˕sKRM 'T^4رN?9 f-fXֈ%&d4 @ݤ.6BSl[YCy'"}՜O%k8sN+) v0nOg0; ԺTSGzv!KϥP!Lrec M e!uV8^ⲱ2! FiA6x;P!g+h$E!BX9/ @!B8' wA$zK&v*HBBNLttp:B'N)!J]1P %L&fyG%(B- 1&S'5eT!N E4 ӡBաf5eNkmx̼VH$Cc* FTn CCW[Np%72t&׳*tdBU9=Azn8I獛=S8X|v x' n\SH4НŻ-x {Hmn5\9u]IۘOH4҅ic7T(kc1--$黡=xOsL+9p{7^q wwuh'G ^UbjfB)=ԞVto@y(vBvQzq@Z#hA- RTԎ՜#xom=TAY,wYuWP`Ѝ }+!587v+ KN*L'pO2! )[r-7DfBdFIBAHHC'zn$,J"i|h_ !2#31yIJ T(&%]eϯ1![HTz~-z'Rp:eQ}:X ̵`agkaժwń  ȣVON K2^.mBO)q 7%sg Ô:pσ87p~ e=J:2 XBJpڦw+®The*WOzj_r #j8WZ{u^>'\VK05¯f&YP[o8<ʁֹLdF[N7.=>stream endstream endobj 1077 0 obj <>stream endstream endobj 991 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\213\025\r\020\203 \006\221\025\006\025\f \221\007\013\006)-10(\026\220\017\016\006\n)10(\025\202)10(\025 \222\013\n\002\020\026\220\205 \002\013\001\016\r\025\202)10(\025 )]TJ 0 -1 TD [(\201\016\225\016\n)-10(\026)11(\013 \221\025\006)-10(\007\016 \220\006\006\016\017\016\001\220\205 \221\220\007\025\001\220\201\ \013\007\216\001\025\203 \n\220\006)-10(\026\020)]TJ 33.357 1 Td [(A ne)11(w meth)11(od for w)11(ound defect closur)31(e af)-31(ter pilonidal sinus e)21(x)21.1(cision)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf -0.017 Tw 10 0 0 10 42.5197 724.8299 Tm (\f)Tj /Span<>> BDC ( )Tj EMC (\027\036\030\026\f\f\026\f\t\r\026\033\013\036\005\f\016 \n\024\027\024\027\ \017\021\034\033 \030\026\n\036\030\024\n 8 \023\024)Tj /Span<>> BDC ( )Tj EMC (USP, )Tj 0.033 Tw 0 -1.218 TD (\022\024\021\024\030\031\033 \r\t\r\024\007\017\035\017 \r)Tj /Span<>> BDC ( )Tj EMC (\007\027\036 \030\026\027\t \017)Tj /Span<>> BDC ( )Tj EMC (\031\007\036\030\032\017\r\026\035\017 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\023\024)Tj 0 Tw (-)Tj 0.146 Tw T* (\n\024\013\017 \026\032\017\n\024\r-\007\036\030\032\026\035\024\022, \021\ \026\022\017\n \024\002\030\026\024\n, \235\024\030\n\017\030\024)Tj 0 Tw (-)Tj 0.058 Tw T* (\r\026\035\017 \253\002\035\024\022\017\030\031\033\013\031\033\273 \027\ \017\021\034. \003\026\021\036\n \023\030\024\017\r\024\007\017\035\017\ \f\001\017)Tj 0 Tw (-)Tj 0.257 Tw T* (\r\026\027\017\036 \n\024\002\017\035\017\024\r\026\027\027\t\b \235\026\ \f\006\017\026\035\034\027\t\b \035\024\f\022\031\021\024\r \027\026\007\ )Tj 0.04 Tw T* (\023\036\030\235\024\030\017\030\024\r\026\027\027\t\n \007\030\036\027\026\ \032\024\n \f)Tj /Span<>> BDC ( )Tj EMC (\n\024\027\024\027\017\021\034\033 \030\026\n\036\030\024\n )Tj -0.025 Tw 0 -1.218 TD (1 \023\024)Tj /Span<>> BDC ( )Tj EMC (USP, \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\n \007\036\035\026\035\017 \023\036\030\r\t\005 \031\036\035\ , \007\026\035\036\036 \026\r\016\t)Tj 0 Tw (-)Tj 0.006 Tw 0 -1.218 TD (\r\026\035\017 \r\021\024\030\024\005 \031\036\035, \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\n \235\024\030\n\017\030\031\016 \023\036\021\035\033 \017\ )Tj /Span<>> BDC ( )Tj EMC (\024\007\027\024)Tj 0 Tw (-)Tj 0.034 Tw T* (\020\024 \017)Tj /Span<>> BDC ( )Tj EMC 2.348 0 Td [(\022\024\027\006\024\r \027\017\021\017, \026\021\036\n \023\030\024\r\024\ \007\017\035\017 )0.5(\253\002\035\024\022\017\030\031\033\013\031\033\273 )]TJ -0.002 Tw 20.896 9.742 Td (\027\017\021\034 \004\036\030\036 \023\036\021\035\033, \026\021\016\020\ \017\r\026\035\017 \r\021\024\030\024\005 \031\036\035 \007\024)Tj /Span<>> BDC ( )Tj EMC (\023\035\024\021\027\024\005 )Tj -0.001 Tw T* (\235\017\022\f\026\006\017\017 \023\036\021\035\017 \r\024\022\030\031\020\ \027\036\036. \215\024\f\035\036 \235\017\022\f\026\006\017\017 \023\024\ \f\035\036\007)Tj 0 Tw (-)Tj 0.246 Tw T* (\027\036\020\024 \031\035\026 \r\t\022\026\035\t\r\026\035\017 \253\002\ \035\024\022\017\030\031\033\013\031\033\273 \027\017\021\034 \004\036\030\ \036 )Tj -0.04 Tw T* [(\r\f\036 )0.5(\f\035\024\017 \027\026)]TJ /Span<>> BDC ( )Tj EMC 4.86 0 Td [(\022\024\032\031 )0.5(\027\026)]TJ /Span<>> BDC ( )Tj EMC 3.423 0 Td [(\030\026\f\f\021\024\016\027\017\017 )0.5(2\2263)]TJ /Span<>> BDC ( )Tj EMC 6.679 0 Td [(\f\n )0.5(\f\035\036\r\026 \027\026)]TJ /Span<>> BDC ( )Tj EMC 4.876 0 Td (\031\030\024\r)Tj 0 Tw (-)Tj 0.195 Tw -19.837 -1.218 Td (\027\036 \027\017\032\027\036\020\024 \022\030\026\016 \030\026\027\t; \235\ \017\022\f\017\030\024\r\026\027\027\t\036 \027\026)Tj /Span<>> BDC ( )Tj EMC (\235\026\f\006\017\017 )Tj 0.106 Tw T* (\n\024\027\024\027\017\021\017 \r\t\r\024\007\016\021 \027\026\030\031\032\ \031 \004\036\030\036 \022\024\032\027\t\005 \022\030\026\005 \030\026\027\ \t )Tj 0.252 Tw 0 -1.218 TD (\(\217\017\f.)Tj /Span<>> BDC ( )Tj EMC (4\), \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\n \f\r\016\t\r\026\033\021 \n\036\032\007\031 \f\024\002\024\ \005 \022\024\027\006\t )Tj 0.034 Tw 0 -1.218 TD (\022\026\032\007\024\005 \027\017\021\017 \f)Tj /Span<>> BDC ( )Tj EMC [(\235\024\030\n\017\030\024\r\026\027\017\036\n )0.5(\031\035\026 \027\026)]TJ /Span<>> BDC ( )Tj EMC (\030\026\f\f\021\024\016\027\017\017 5 )Tj 0.099 Tw T* (\f\n \024\021 \022\024\032\017. \200\t\001\036 \031\035\026 \024\f\021\026\ \r\035\016\033\021 \f\r\024\002\024\007\027\t\036 \022\024\027\006\t )Tj 0.164 Tw T* (\027\017\021\017 \007\035\017\027\024\005 5\2267)Tj /Span<>> BDC ( )Tj EMC (\f\n. \221\001\017\r\026\033\021 \022\024\032\031, \007\026\035\036\036 \ \f\r\024\002\024\007)Tj 0 Tw (-)Tj 0.113 Tw T* (\027\t\036 \022\024\027\006\t \n\024\027\024\027\017\021\017 \030\026\n\ \036\030\024\n 8 \023\024)Tj /Span<>> BDC ( )Tj EMC (USP \f\r\016\t\r\026\033\021 )Tj 0.093 Tw T* (\027\026\007 \030\026\027\024\005, \021\026\022\017\n \024\002\030\026\024\ \n, \235\024\030\n\017\030\031\016 \023\036\021\035\033 \253\030\031\004\ \022\031\273 )Tj 0.007 Tw 0 -1.218 TD (\f)Tj /Span<>> BDC ( )Tj EMC (\235\017\022\f\026\006\017\036\005 \f\r\024\002\024\007\027\t\b \022\024\ \027\006\024\r \n\024\027\024\027\017\021\036\005 \030\026\n\036\030\024\ \n )Tj 0 Tw 0 -1.218 TD (1 \023\024)Tj /Span<>> BDC ( )Tj EMC (USP \027\026)Tj /Span<>> BDC ( )Tj EMC (\027\036\005 \(\217\017\f.)Tj /Span<>> BDC ( )Tj EMC (5\). \202\f\036\023\021\017\004\036\f\022\026\016 \023\024\r\016\022\026\ .)Tj 0.293 Tw 0 -1.218 TD [(\200 )0.5(\022\024\027\021\030\024\035\034\027\024\005 )0.6(\020\030\031\023\023\036 )0.5(\r\t\023\024\035\027\016\035\024\f\034 )0.6(\017\f\f\036\004\036\027\017\036 )0.6(\215\025 )]TJ -0.059 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\031\001\017\r\026\027\017\036\n \023\024)Tj /Span<>> BDC ( )Tj EMC (\024\002\013\036\023\030\017\027\026\027\027\024\n\031 \f\023\024\f\024\ \002\031 \023\024)Tj /Span<>> BDC ( )Tj EMC (Bascom )Tj 0 Tw T* [(II \(clef)-27.9(t l)-31(if)-28(t\).)]TJ 0.432 Tw T* [(\215\030\036\007\024\023\036\030\026\006\017\024\027\027\026\016 )0.5(\023\024\007\020\024\021\024\r\022\026 \031)]TJ /Span<>> BDC ( )Tj EMC [(\023\026\006\017\036\027\021\024\r )0.5(\002\t\035\026 )]TJ 0.063 Tw T* (\017\007\036\027\021\017\004\027\026\016. \212\024)Tj /Span<>> BDC ( )Tj EMC (\024\023\036\030\026\006\017\017 \023\030\024\017\r\024\007\017\035\024\ \f\034 \002\030\017\021\034\036 \024\002)Tj 0 Tw (-)Tj 0.027 Tw T* (\035\026\f\021\017 \r\n\036\001\026\021\036\035\034\f\021\r\026, \024\004\ \017\f\021\017\021\036\035\034\027\026\016 \022\035\017\n\026 \017)Tj /Span<>> BDC ( )Tj EMC (\027\026\027\026)Tj 0 Tw (-)Tj 0.188 Tw T* (\004\026\035\f\016 \026\027\021\017\002\017\024\021\017\022 \017)Tj /Span<>> BDC ( )Tj EMC (\023\036\027\017\006\017\035\035\017\027\024\r\024\005 \020\030\031\023\023\ \t, \023\030\017)Tj 0 Tw (-)Tj 0.089 Tw T* (\036\n \022\024\021\024\030\024\020\024 \023\030\024\007\024\035\032\026\ \035\f\016 \007\024)Tj /Span<>> BDC ( )Tj EMC (7 \007\027\016 \023\024\f\035\036 \024\023\036\030\026\006\017\017. )Tj 0.261 Tw T* (\200)Tj /Span<>> BDC ( )Tj EMC (\024\f\027\024\r\027\024\005 \020\030\031\023\023\036 \r)Tj /Span<>> BDC ( )Tj EMC (\023\024\f\035\036\024\023\036\030\026\006\017\024\027\027\024\n \023\036\ \030\017\024\007\036 )Tj 0.049 Tw T* (\023\030\024\017\r\024\007\016\021 \036\032\036\007\027\036\r\027\t\036\ \023\036\030\036\r\016\022\017 \030\026\027\t \f)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\n\t\r\026)Tj 0 Tw (-)Tj 0.017 Tw T* (\027\017\036\n \023\036\030\235\024\030\017\030\024\r\026\027\027\024\020\ \024 \007\030\036\027\026\032\026 \r\024\007\027\t\n \030\026\f\021\r\024\ \030\024\n )Tj 0.115 Tw T* (\026\027\021\017\f\036\023\021\017\022\026, \022\024\021\024\030\t\005 \031\ \007\026\035\016\033\021 \r)Tj /Span<>> BDC ( )Tj EMC (\026\r\017\f\017\n\024\f\021\017 \024\021 \b\026)Tj 0 Tw (-)Tj 0.076 Tw T* (\030\026\022\021\036\030\026 \017)Tj /Span<>> BDC ( )Tj EMC (\022\024\035\017\004\036\f\021\r\026 \030\026\027\036\r\024\005 \032\017\ \007\022\024\f\021\017 \027\026)Tj /Span<>> BDC ( )Tj EMC (2\2263)Tj /Span<>> BDC ( )Tj EMC (\f\031\021)Tj 0 Tw (-)Tj 0.349 Tw T* (\022\017, \017)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\032\036 \023\030\024\017\r\024\007\016\021 \f\n\036\013\036\ \027\017\036 \n\036\032\007\031 \022\030\026\016\n\017 )Tj 0.235 Tw T* [(\031\001\017\021\024\005 )0.5(\030\026\027\t )0.5(\n\024\027\024\235\017\035\026\n\036\027\021\027\t\b )0.7(\027\017\021\036\005 )0.5(\235\026\f\006\017\017 )0.5(\007\035\016 )]TJ 0.225 Tw T* (\031\007\026\035\036\027\017\016 \220\022\f\f\031\007\026\021\026 \017)Tj /Span<>> BDC ( )Tj EMC (\220\023\017\235\026\f\006\017\026\035\034\027\024\020\024 \023\030\024\f\ \021\030\026\027)Tj 0 Tw (-)Tj -0.054 Tw T* (\f\021\r\026; \024\f\035\024\032\027\036\027\017\005 \r\024 \r\030\036\n\ \016 \n\026\027\017\023\031\035\016\006\017\017 \027\036 \027\026\002\035\ \033\007\026)Tj 0 Tw (-)Tj 0.029 Tw T* (\035\024\f\034. \025\024\032\027\t\036 \001\r\t \031\007\026\035\016\033\ \021 \027\026)Tj /Span<>> BDC ( )Tj EMC (10\22612)Tj /Span<>> BDC ( )Tj EMC (\f\031\021\022\017. \221\255\036\n\027\t\036 )Tj 0.045 Tw T* (\001\r\t)Tj /Span<>> BDC ( )Tj EMC (\227 \027\026)Tj /Span<>> BDC ( )Tj EMC (21\22624)Tj /Span<>> BDC ( )Tj EMC (\f\031\021\022\017. \200)Tj /Span<>> BDC ( )Tj EMC (\022\024\027\021\030\024\035\034\027\024\005 \020\030\031\023\023\036 \021\ \026\022\032\036 )Tj ET q 42.52 383.042 221.102 220.009 re W n q /GS0 gs 221.1023245 0 0 221.3328904 42.5196841 383.0417326 cm /Im0 Do Q Q BT 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0 Tw 9 0 0 9 42.5197 372.2417 Tm (\022\t\217\210\b\002\220 1.)Tj 0 0 0 1 k /GS1 gs /T1_3 1 Tf ( \212\205\005\203\020 \025)Tj /Span<>> BDC ( )Tj EMC (\t\027\025\211\031\027\020\031 \n\024\027\031\032\t\024\025\002)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0 -1.2 TD [(F)-16(igure 1)47.1(.)]TJ 0 0 0 1 k /GS1 gs /T1_3 1 Tf ( Scars and \233stula openings)Tj ET q /GS0 gs 221.1023475 0 0 249.9104748 42.5196833 101.0272753 cm /Im1 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 9 0 0 9 42.5197 90.1959 Tm (\022\t\217\210\b\002\220 2.)Tj 0 0 0 1 k /GS1 gs /T1_3 1 Tf ( \215\t\t\031\006\031\021\021\026\002 \033\025\023\n\021\025\030\026\023\ \022\021\026\002 \013\025\t\024\026)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf T* [(F)-16(igure 2)16.1(.)]TJ 0 0 0 1 k /GS1 gs /T1_3 1 Tf [( Excised pilonid)26.1(al sinus)]TJ ET q 274.961 100.996 221.102 216.014 re W n q /GS0 gs 221.1023475 0 0 216.0609305 274.9606228 100.9491981 cm /Im2 Do Q Q BT 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 9 0 0 9 274.9606 90.1959 Tm (\022\t\217\210\b\002\220 3.)Tj 0 0 0 1 k /GS1 gs /T1_3 1 Tf ( \240\n\005\025\023\025\016\n\027\026\021\021\026\002 \002\202\n\030\025\ \006\021\026\002 \f\026\t\203\025\002)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf T* [(F)-16(igure 3.)]TJ 0 0 0 1 k /GS1 gs /T1_3 1 Tf [( Mobilized g)13.1(luteal fascia)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\033\030\031\030\213\b)-20.9(\035\231\213\233\t \021\032)50(\b)42(\032\231\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj /T1_4 1 Tf 25 0 0 25 504.6396 56.0378 Tm (131)Tj ET endstream endobj 992 0 obj <>stream Adobed     '$''''$25552;;;;;;;;;;   ####''',,,   ####''',,,   ####''',,,""  !1AQa"qB #$%&'()*23456789:CDEFGHIJRSTUVWXYZbcdefghijrstuvwxyz!1AaqB "#$%&'()*23456789:CDEFGHIJQRSTUVWXYZbcdefghijrstuvwxyz?<s9O5)m99d-(J\\#."vW8XA m)RU-b0hoՉ*@7r*X͋m2 q փsMF@ q!U`n0ٴ̳/ crIټri2 t݉t nA- \Zq [{ba$Z՜sa+$$ ^!b!K4[ N̓0BNABrHV::ĺt vÁXBL ,,㎡@PX+ɪ=G- G KbPIud)ټ12@M$.P@'nзb:4J |DBg"9.& vb8k@RT4+%4^ErzQZEe_(ƚ,H%hW& S ܟ!8JֵL\庳ʛy>´7Y9԰(z U![^sr|N2r2|CCh$b@Z䀦ēf@Y e6 N|€nV-(-VP j"`TT l$ V-d)!RhZ[N`з3%bZ 96%"hrvZscY*:0ym#.^爌-hjS]`΅$&rf)*/r XW0wfFI:ՍoZRv"JLj;%LB9(* r;EP;|7y5 ot$tѺ΢)^NXUhL[F@.Ppsu $4q7FAT O{;3`Io |X )Ou)'S:ȫ(B@k$J2HəHyF|΅-٦H:VFZKQ\;tTSͤvGRga*@`I0w2BXh!7QCu OiN3`87)ɻd17yAOēCm$=Gb@/,66NJKM]rX&i7{ ddZ7f5-(} ʓvԚЖuM03L4%c%x"sVNMZetB&-+,xKL-K@`T2&6&r w2Liqa|Gj-aJ6Έ=@  tdm%m fPl,ɘ3nMQV&s0S+J0ݡwu1EXmhI~44=qc34 {QCRB8cSuܶf{g+\f9'X5wz!ӽGcbe`fpcI"N 7#d FBM@ e)31, c*IF$9q2co q2OC(9ǓPwsijfŪwEU5)y\(EV6䠭i_%=$cQ^%v+4 )r LmYd<59SD{4*qoB>f8k5cE|v˦j9ou~4]hmuKej O#&|,0cZ&lj];mgRxA2"fǶ}BYSG Y/+#sBdb: v$$5et˘\"Cld\1}(VAr nq5-%$FwhPNMK(ohr{- FŎITĔm`3n jWN$y9ʵt7:or dIG)+%Z 6X3R@Cssdkj2{E-05̱,2RQ'.{+SjMf&N5DPJ XT3~&cG,]X̰qJл֮[wZhL q*D]َf@)!lm:TF´ok-'7z*@贫sd% oLQ@{8Τ~؛M+Zh1@\DqBvFaW-v|4%uF1}N3eHfj :i4de-2n=dn&~8p٬ڡgFlv}48jrlWVji\HLe\e:Rɠz+AEH;vE H&]p2LD URp}P`ٔh;ᡦ9:GܕiC̳8>Xr1$1jJ҆er>bmT̟)ٴZ\;M^:ijϰ`J4tDoC,,8UbY%0cK#I0ptysȍfh=YЋ=1ͥB^Ȉb"圜Σ7­GMC1-sIMf- cI[y4ΤɈ̫+Pd55$bZ.+Co8F/gJd]eRBńgn.!:Y2wOP , A3EUXaFlh5,D٘`fωh&L$/9cѦ3 P2i,o|2u:7\ed`k9GA&)boۯav`4ܴ8{ z31LĀ Wz[i48N.9ݪSVFm IQo܎ݗ"휖p cC6[,;@\K1o]'Vd/ Df#w jδROGM+c{yM08r!)޸3LH0RQV4|lt}0v#LX4{y/v#[E:[D֣rEF%M_ 1chĥe`B;Ԛ|l6$dtDdΞmLLd4jS$2wm>ޤ[GE_mݴ-uozJMJ,Ȉb.dgzp>̽jL|8βJ6Gs9lH&Nl:-$u$#-]j C:O9/3KeZeS34\%`E.#0m'ESZY;ApT#͒3 kZah m1JMzd>j$T3 >T2؎XXa>@&ed$u yn*s S7apd89S< ØCؒ{Hɴfɾ^_Saɤ1}<5 Q\zeϕh ODsKҔǰ3ͷtgW׸bNg=*m 3 yACik-ǒ=;X=n7q#:MtڅUٜ%hM,*]Wk4AldEұ%C;٭ H} `7,t,ɋb;I-9d{\ 0ѓ7w'X`LF#tN=bN}4F*QRJRZ2YSKQj̍B75a1fbf&nP{DIVBZ&.ѽ$K fh$I2:f1Hވ!)4~ieYb"U -dΰrh7yZ|(ݒgάJr'vv& L$ДI2 uc[Ѻ +Ml(mيۼ䘉 (%EO̳HyZcW,FW`Uِдcr2k`r2# e@*d>@m`D1ipzT6um%K xq2B5U}>%Ec-c.ߤhvSZ9@eI@:.h E:MiOIA(9.A"u#0S GJo˷$ 'k[:xl%9%N McQ^F:@&wNowd5'w7%\fH5%\BPVtqRL38S0HiZiʻt.Rq&I fh2~wSdP̔EOX r\dܓlLMvCɿFKc&#&b9x7t#g95O Kj<>/b$,Nb331dDc'[&E3> M#*b#]7{]li5kw9CݐQ£Y kNf&&##'.p_q8{z [T2XrjV S-]:&qɾϷɼZv;R"{[IzX&!7 u34SOck% aմ,lނ v0bg暈Z2D4]bPXқI /itG (m[VD%偓"Cm7-uv%5 bb!k KL`rNXVLkzqͫX {0 1ڲ6|)R Mo`gh& (h6*PUdYmT϶Uqͯ)NbkXً dng1DbL!1rv$#UseQͪ2oJuwCs(d3"x $Hk 6Ps& q@ej%EhxXȲ޵e`9^CmPief vihʰbdd:灹J;Ν \ξ\BV5,7jUwvޠ3kY3(Pހ(ضoZiFRfpGqj6]ź`k"vձ/b[&gf'::VLTgx.^L\mb'vͷI$evcuʷo7e197E K'ʉʌ.*1¢u[ldQɜzpN[.RFTeLN*4Y ڛ5VV^VLN"nskcROg%Qz 씔Rʍ 3˥)z'fDkbMYSO/ثˣ蘝;7Ralm;g藽mCuX<.,Ƣԑy1cRh2bfg]S΢Z#s]exA-.K2,9䲫ur2M [M˷)Λ\ByYQ1o:(Ei(!oT#dp|Z. /xq{n9[\͗29bt=Iql%|ԹSݶqX9m@n;6zŀ䗉,<|A!=t(U# \n6ѥ@t^U'o.3 'IIc6poˈI~6d`a鑶cz ' K6i ;E(e%kl3JK'\xx⸋6ԥ&+K=sfN45c&6,Ɉga,NF8m'ryʱ]q¹ftS".K@g5q7 {ΟVHKYedLr41Q1[vȣJUu<ҠgyY3쬝Yfrq"SkyzG]s}=43li KwSɯFNVLE\icڱDF8'!Qib4rtؙʉy{1$uvG"E xP(%v459S9Sgg+6X1G&C#Crib6da$=4*Iju0ŌR_f BOUF^&(‹CE""MC6:RmauEzpV]7wXq)=Xx2w&jrFQi Jl6GVұV6^t,3veб۩ȏ,G-rvFsn)<;,)K"5wR.9xJ6Mԝ-,]qtE5&"p+o,6+[`R@޹:Fm$idIXmkB`G.v`jFd@r8J%el -'qJɘA<\kqIrXAs΀ش*cM;,ՙYXMͪN2)6Φ[V3LV'Xa8ɥkGؒg&M L팈VF&;4M7UYgld|"fc]Ԧ+m={&3OQ84mpND^wZ&}f6Ye\EN:I*}&n)3X4"4v/Q깘Fw6 >sS芝.A视Ȅ_9+&41SDNrJa ,<,Faq'P$ϥ\\dFXΖdd1FZ-;Z$L ĀuW"L$Ű5 d݀=vgFe\SЊP5̑ Tȍ;Q:nc\͉̀_Oug'FMc'DNb6kq*u i7| 䭹Xy\U88#bo.CHCi9I]3E=Mk/0˷|+`nF/AmⰬ+ 9J&[!7f"@ ֧VtVv(4'\P`O6ZK^ L-`NjY` bk4L,%muCSj%QCvFY(F1Jy:OI.302MAxl(ŊJ F49Ĕ 贙g =:@mid}{T܌U'LNZsR&4<ѮC%l:ms w &p]K{"rgCSq]k1S& Ӥr"gE9|5&VV1QySȪ4r+\c?Yó9WS7cY m*m,3&1bqO&&p ,d1IT o4{Ό1T!ERwC X3 I1RfNhT6X$2 wFV4%Qvw-m/8`;.[i.C0C,{C=)n)^l0 VsEsXJX3 dȔ#Ψn5;]fXa &g [agl6WKc4-ܤ[2kA5.`YgK{Pe=1t#A*dKq-Q2$I=A.(ޭ7VTeiPՃ(y M;Z مsŝz'm32ĀI0%H$d ta(ricmiJ%NmuœI`i&)(fc&.VDimb6g&-*DL%Cymfa*eJDDmPqamgՌ/"1K':465b2bf~F:yrLzp"-쒶m4O+2̹bbk×5r0ͯoFLdY>O/")ꆰ#_)DҜfѐ#W1TRWYh ^!i e,m)919Q9tu."4Zv%ʪó'HrՑa7KyuǢNR/NLu5]AyZ ͛ӦɃiuJaY7;|Pu0º4i9c0t %gbRB`QwCiqK!lo*(fɨ&0Jgc*"3IըxnI Mb˜;X6yR ͜.Zj*\IAL0:"Zz1b5l*ܩsc&g6v(ԓQ3˓^յ#]fUOcx4%vT6sD9yy1sV< K1Zs/Ph2#OiMUx!rN)a*`}cP y5X,9II51kP+\]rGh[4WK5bik :J[U]iB]=J/mDKOe1[c0ڷW0 ؅;,b@۩* ;u5c2:Mp(3U30pzTS]3W!eܥl +T4i , :8jva(E<[GFva8[ aNF ֵVlJ]uD,vDvY7bLN9ɢ%*r)F΢S7[ڃP}&'Yi>Krv97<.#+'E91dl"2"ִvItZ՞kM A2b&,d6{ЇI&.(ɘʋ'"93{ <&ʧReN^N\Ίrt=;,7Y/錜ϕJn.};(ʆ)͔dDV:[Z9qO)Ȝ&TVsQt dagG*/X+&a!o 7Ŭe]19+pF)Pd?Le+U+T`$9^%#tFNg*ĮI6ްb/Kc68kQonc=h%_TSٶ*؜ PhOx]RhGqdAO>l |Vl!իѷMҒ3PLL# YQ3 &c2= )s2vǶe<fG!P=$.V^ykdnNɜdpe{)ԓ5$W.9t+QX1@Pʹ%dF/uJ<*&:),HObroM-_beDd=҉\`ҳSrj⎝V;m;i6=&+DisZ'[RܹUΜNWMI$V6Rfb Ĝ3+NVˈ$ڋi rÄަc VX10-ک`em`i-z񱷵r2 ubҠ7Z4)I0'k')˨ۻ0 Q$ݰAc:PRQ81@w IuœVbpe*bXbtH=k#.\Y U9aL,ƂF '.ikt"C:Ζ]6%;re)SɲɌɇ)!4(b!vL!&&A)!9I Hħ cQʼȐ vtR07 5C:"k3cQ.^W$;2\!pd;9:ޢYGcRaydPʖud9s E{'Y3k `e5 2dj8/ȨB%8MdsfAC ԓprc%]RdN 条ȝl&lW|H9^8:k]W995ٞ'e1m/9Ent[zx]Kvd`M0fxٙbI31ų:VMMGf`scB[U>$fS98ﾶ"Eqy11Y:r8fu˚8N(n:Y~(V^V~]f22rjrfc]0zEɜ>F*8jn6ֵ}ov)'Q*3W! Nyz+&q9ȹk )`uJɼ V9ISS+#RL捭ȜƱD kʉҎqR*j&@kdUW.rj~Nɾ Fɝ*-'ArZoT3#&}bZy:+>k['&*r#>!3MFK9$ U9#˼#QLDVVxg&"'4v|߽A\3hj [1D\YӉʘ! ,E779ZX:93z}f3T G3y,nT|!ơE7eVfWs@$l-y%-Ab&fZ1sȊ+ee^FMa_0(3xh jhش5$LMiKeM556MMPb2SQ3YNg9u*iVɼwnǡ#LfzlZ"c^ORMMfov5E;MpIa #2Ӹɜg6I9Xٖc)&d)+bKF؍I1{˶K4z0ڕcqK'}1g`Gx@e; lTgɌv+2u-dTc搈ҝ<Ӷ1WeuNMgNX >x Iqϥq{3y970R9ޝfLoN48iah]&Td5VΖV2pʌtMgg.rt9'\UDU;q6JRFvgwiȈȉ꯭>Dhʙʞ_3djvOUW.c'd¢gJcxt=0S5tz&jc:2frjóZ/+5eiZf3v4AwX$3cK/PDFLTr陸UƠ `ٝj,n ƢN [.qe4OQ8<qlυknF6O'PeDĞV-ތc}#F-x9qb2g_cϓmvc.gc&Ʒ͔ N%'d5NiLT;lMDɘ:kszo#"u+5.]sg~\|F,^66O9rCcnɨcc9:#favqr̓au*/_k#d15`);QgIVqWmd31ˡ ̻"bty [ dr"#_ ɍ{_QV<~LVp3W9QA(L1lTJQ85\SԎ t]11q4U-k즪r3u"uir"M,T旌VDd<ɬʆ(ucqȑEr2Fx}[31ZC1+ܽn6TO D(ƣY"'8JRgyjdtaԚqXʲF'?yU937qڗQQ˩& gxԑX޳29yYUPcEeiV;#oD&O9oI޼@NN&&&1џ91q9S_(99Q591*+6ͽ/kxhL;1%Y-fNɴ퓗&s֝dh"y~MirM[*3tN^ 9Vtw*Y[*&+ { P>+2o' o11E[Gn݄4\SXyOčJG+PDhbfg[˕3ru$LVLscSԱQG/ m-ׇMC2ŒN9i*ˌb+Xr'}.~\L\VEDkcN\V4 W 8r3I~^UΠ(Z ލ]ZIʉZu.F* S<ʜD穼ӬyJT$ۚ:)NrroXW1:Q+PaWzqyW$JMi1N32^UDr]F=br/AiݧBwV13(őDif2uTׇI^F׼nr3Ĭʈ9Fʲf#_kcSeeQmrPMgAij؝E]dD+]J2r+Eqՙ|33h K p`ld]ɼol4fO'e1yqY1GfS9939F-&0(st37̜jM3+SMDM'b*d 9GQ2u>W/xKq:IJu1zg<ZԩƤ t:93L~5"Q9tRJ̌mx9d5Sr'56M0FV"N3d`sZ#+*gM9U5F5.9Tdzf2ܛA1-aIr\iLp ii9ԂeN2rkCb4zQeec:Vz&oJQFLZo`)1LSF'O2r D.ep< Sԑ95؞}p4U|hjj= M츘>_RRVγL%OuT3LSΣhUdry EZgU..Q9[O ")23ʍ)\:Q2rgEY45'dy3g&Dno&(Y0# y3ZjKS5XVĢ2 kSȊw˳Fq W(5f%DeDdTUVy>ƋCqIʉ'=m=3;+6-xS&pcC2g Nr"r2sa'뗑)/\6P)+O&2Nf2'**">8<+ ӵsY973{Q&<{o CUΖMkfsSy9W8Vm=<[s&]&V*g +Hɭzo4g6DDq:2['Q/LFG/>9M$84OTTᢨq2j9۳Ofcv׵#ReeLC8;5qCmf%(RTDvMg#*" 4hqfCQDkdʹRF ru,pP-IvN_.hdeLldeXm Db7rrZYV<]f 6(+ ySd5˲9["aO*boKӂo fo4ɈcRNV5'Rej<{8Z9EQa)᩸Y0VTe]\K9ZtY3Dxȩ(L1:9U2".9w.SUޚ\N JflWq79z&f9zq?/:s1-3Rj(Sٌ^LLƧb950ƪCg7I@LN)ϷUr:y9E{N5,a]q3X},c T8M2bfC"Ĝf"h->JB-KMi'9RMQ:ʲ"*fgNLNyt4NqBުr@VLUָ˜Ƈ"3e]Y$cm.DFZqWF9<['J V8Թ3b: ՙm9y3N2R^ VKKpΠʮ]-!B#+PeƱg Q́Gm=e: l+/*9Qdt| '33$LdD֛S&1 z}ZO:QP-Sft(XkFr&%,ɉj}eh&J;d^GxӐ Etu|teNL˥RI9-Z#3-F^FZ4WY G9XƱ|eFLL1n4;`U"d319N˝cZѲ*lI:=d1%BXsM!׮G959hi*2"sk4y)L/'U p53=m+Ԛ2򢣗J[WE2- 0gm1;:ȍkƥp[Q1zق*.L>TM:Q15ˣ6xVybg=c`![3bGɼ65QdeN55cs."j&G'QDDFO;+L1M\?fLj<ȝ}}jlΣi1r鹉N{shݟ[vtDLh"kNM-1:G/g''*t˾ 9*Lc2:[q'8NLƺӟޫ9G{5A(dwLfL,9;KZvDȣDk8{iY#M\DY4Db ZCJ-<<.و)`\r&#q:j3f2fQAebJً[&gbNWBQ5@:1C^`ddD田ȚUƛ9S5GVrRřrGE:Xs,LeB6#r3`hوd.u)DVG8-ZGTN ݜbns/-]V9yZ9zZ9zMٓN:iVhb2/vFɜ*bTeH3ճ2**qcXeՠ^ΊyhԱb=U3Q1xk'Qf.oDh7N}*n/PR^[sRdDTb[1"o'^*g*;b#Fn9yfn͞RɚٵdtcUF9vR ^\r"ꥈ[SW:jrE#4V,Ъ"rM^Fm cl^9Uzԧ#&2:WS endstream endobj 993 0 obj <>stream Adobed     '$''''$25552;;;;;;;;;;   ####''',,,   ####''',,,   ####''',,, ""  { !1AQa"2q#$3BR %&'()*456789:CDEFGHIJSTUVWXYZbcdefghijrstuvwxyz!1AQa"q2BR #$%&'()*3456789:CDEFGHIJSTUVWXYZbcdefghijrstuvwxyz??]We;] SL#X< LXVuTMb(*B0z7)9Ѐe$XA(HdN  'D HH7PL&:BB`@&"^J@lŹ:Hy(kiAO ]&i|ۑ@rg ;$tM-ȝ2H;6^$DC$mtG*sY0.tPq MuQ!ǡو0\lPI bO<&fR:j)&!xP@ duOȼ9ba 8NlDFN@:/:d+)9BxhK!$]0ʼ BtJSA6H dty8/7MW y^^i-@`r2- #uJЩ,s$Τ)%0ުPvn2`%Ђ l hnj0 P|tl.MQ6M5KBlʢH 5!jA{jt 5OC]Sڦ{ /4H^u":$fw^"$A) >yuJ 뢌t:EuHdcX Ohd$:6T Ɗi8{@br8 emKƷrYȠD7rU( Y$zɃJO"SF@- $k eAE]R PWSs{]8(uNiʪQDus5ah瘉UIe [Z2c_fsb?uI@;8#^M=acW5JlSl触ϝdƪ"yL]Rn{t:)S+966]nۙZZ vs@ꮒ"8 2Jw|7Ytᨥ(Ilt֪iSKm;vg\ӯ VW0*ht6.GCTpΈ/Scpa\k]BUSWWe5\-kN£S30iN-U*VUgxzbWVaT[ v2PUN0k Mf tw5G2Q9dn}z|his;fڰ&;8wc{uEMek)%;56-Vݧ*T$ OxTT} ɴhy;NM-JJv۩djT#뱰Ʀ5w6 Rĥ V€@oa8y1ܜST< iP^ӳSDP 9  ?R\u!Jd jU`3(tߑChcnw)pwߑHs` B_LeBr& LFs529kA^ց-2NIMJʶHkm+[Ѓ:)Z] 2#b5PM lSm&IS%g0sŠ )i9%UQ7JZ%1!. ^ h<:]YA0E$*g IUf ,K5v@qnjK`0&&SqΘiԦQa;O@XrhT]sd+_X֩O3JFf򥖰\J+%Q im| pUnPQö6Ѧ2EĘnF*WrbFð}RcT=T-dD{ESF==bI,Lee;mn[rM:n)Y^UMq mA _Tu\C޻;bЮc>`㟤f0Vәf[Z˖VAlTbgvw鞭<̯ J_ݩcK5;56L.{l֝.- vwsil8r{) S[j-:9a`z:MBRU_Eh **] ۤkБW^-Ҕb:RQ{8NuKV}Whӛ,kN乧V:éM9} ʶkE#e&%v mpAX[\.n*zZ=URir>**}H<ꚪuUMM{3amfuUNe^XuST`F,)[K6߇RI$*UQW2Z{ jVKHYU㥕erYFwꪝfXt[VyabSSsԴoNc{nBj^'n8-%J^)A)z!$6RQb̩[6jĦUi4 xLꚜfs5$:*mKVU[N"+$D/4XSIyZCbb78iɶkiӆ&;tNm5zж^vċ>#L4t[o6*Li1duL񱹕^ ͉3O ĭ-'Pq^XOEA`SEy--S2cFKoE8rZ7@pD}kxM"W\*_S17>ג|4֩Q QckkRf|5vwSŢzƾ@/ʅ P%xWXh#^UV%t\;\zt(LF`Eʚ4B\)9 Z-麤X(0AO`/a;ܨ ӍUm^_<.hliMJqhi *<|œU.*4zE1aʺgöQ@UwiD9Ṯq0𲺕U,uT|W8u1=V~>Z8Ζ 2 !Z24ʉkԚCEH;mXއ0.$]UTӦ!ceJB/kˁKt+Bj \Gfgxn*i\3Add 'U@jxt mXҧ}1v\,|*1iĩӀ\M atTꙔOmU-pM.yij>LJjg:b[ANlUԤƕxt0Scٱ(\SS"CŚU3N*ڳWK(NΪlCö LD0T쪑ˢXo_U$sOdTl5:V]3>gWgUHαtbQӉ5_Y%wIƱǦX C'ub*#~UBr3ބ&SʪiL|O5VO=O6-LJUԔ{o]Sq6llmh$쏈ضuҩfYOLkz˝ʤ,U:26 *Te3j]hʙZnefR)6-L~-41-j:G:WtEENuBIӋ.NGb{FJ2㺌0fy:'4i`Bʹ:U//^je>/W%T_o ڕ7UXVWL١R]Qx辑f]Kk( MFW7ES97%ܥ_5KRhǚkƪUeʊbbT8:Hߣgsɭ>͛>u*,wIh'au^Ν^B Cdا1YL]UM*[+tKYȖbi--/qeNjZZ.9 8Y<o'ٱ;%4KQӥ_-ѯpϤyEXkJs{6%QEy/gs9sJ*n);eM8[FԻBIthzSbMU:ay;4VԚkym8s^JJIɷllCvHǴTG-xb4 7*$E,%#-5tEcI֞yS MŒ¾ (,%G pi@| kn1:"|=w0MUUH۰=n\Usw%~%5>nӹ1g=hJOϓASK'fGBrCʋ3+Tpbfe*AsƜFǸ[? i`ԣ!] jUj8V]A{[RJDRt,4qJ@hk1*3>X!N]mR@m4#$*F2E΁>;/SlU, d f)WKŔᢛ!ceó YH@hZed1$2f tw^U ӔD$I9BsH31cYf<n&S SkFcLq.saĀLΩpLȜ(e\DMt 1Βz(zgi7*`SRW*z]THM @W$(h\H&ɢEl T12r^yUmҨTh2A*Y.Xx<`~%r43Qf-8X ț8v;€yh .U"QR9e_f:umJ›vl9Ղ1I*J2ἰMI-, Y"GU^øjVfG&p̩O:=[^5ߐ`Ir"ؓ\{baҝ[2œZu)Kva*ԻWiRsXl ŪRUmt0L#C<ʦ-qʇLJiՀh-љ:&ǷѶx墩ug}iͨU$۞0*XRM:. o?f$4'QfcsM}'fF'zcjubUSn:)uM'浓朔k*>dzBͮw+p-& %1nJ}n.}M{]-*pUv/T`:1ۡz,Y<]iUZò=lOODw7t%Ej5@wC%Ofi+(xYe´ST|ngQMu֩¡*,ϩkul6ϘaUMm5Kd+( E좪^+8|@^_Ulfx\IX[e.ꪺENySb-znw-OeN&tiZSjo*WCS_ƣU5r޺mƯ~4\z!RTNUFb S0%TH8 fS5}O2v(O"i폗ѕ-ztQVI }wCfΤcsJF]3q)R#OhkZ׹6-41hOfjfnF=,#Jƙ !9I ՞:XJs&*)T[3RWuvƟ>X<4ݾ]GSi]N`G4145u#|Q˪~hWyOau&ۋ-[:Ox9VczeĈӕ\N@7-!.l[is=h/ܠ(*ushe#X2fsț Y%5Zń%xQ!Ǘ,{5dJÃe9I* r=k%VDsTs*졜2rBZqWkdTaR6Q S6)&`k "W  4f'N+& -Y^.nc7H`2Re%C'M]fGf";ؐ**UKU>F%{ YP|YptyxVxk: M*jCmNY^8An$u +6U*yvnJea#mԨ Cm4SFztKJj:N= fy.n]3C*UI7U:o~zæo c]D.2zcv5l&[J*kMxͩ<ˢ$ U> C(ڗ?[%mwGΞ&Ft\lTV#L ]TЫ ^]C@Y- :DyTE٩CΐC@+4Omڦ } #ues@ŗuf@Ը"SE8BJY4ٲU  4^dA*B LA9G*y`e)h2)X`6^^"Pf)`% @yӤsOah& @9$hd}M1cʐ=$6U%\pU7V H؝T!ӢdUTAW+RL<;3Iup  ZOUWI2NbTMB{hxWii6%fiIKwtWFDQJW,tM[w*4^LxZi/7#k<ʕVٮuMC2cOO(^Ik'N]K;CRU&<\fn`Sn54Qƪ\ 8CSLEt1r<:iuP1+18w=|ETD7[Pv[KZ>seM٧g=,+NZnx%u\$2x}^T:EM|NfewNJ˪oQODQ*;[$])7[R=k]jde1^'DBןDubIMAT7JET1TLϕ#5UŔkڳ-|x6;Uuzn-6"KP ifse+n+ D{ƣׄ8mU>;cƩ:n(uMjc)4.^:tӚsK/!Y'X TqxXio܍N76>~b¦g66%|>UWkU%Z ݉{&ŶO`sc̒q^o-WTvásV+MRݛ[NjRTnuKsW  dڱuoa@k ;.1u*;M9vMDRÆ@HIgѩZPrlS۱UN{PMuꪺm"K 5NrEOH=0豳 L1d8Cs"wt&6 NTm`7R5P%;d9_{q*wpcIvlƒv`PlR(D!kmnyӚE Me^t$t^,.WmЃexx񽐔@ftHIOkGdj[!(L($@(\s*'QD\4CR oȜʑql6`ȕr]q FM. N2JxF` :^$=DxAD.p{O⥦s 'STgbŦ2.- ԒRp{iժb Lx\#1 9tF9trfq4Қ[=48rMPʜS][ʭnwۯV ?)rʽBZ-zTVz}r,zί5=8y&;C#{OiO\@$nyD;PYy&9je-8oYA^6#TZh|ôJ\TB=QRxiCpySKTdqZ|uT٭OohڨhxU,t+TuNjTSZn=Ndclк^isnHVXCOlVf&EuW[WODy[G29M%gF7[UJJm8k fn<vkƓ,C9noȡCSӧ6Ux9Ӱ=J5ǩۢ>K[t5M+Uӥ [th2ODl,*NsF-O%-6lgkIE{Q=3%-QBT)Ջ.X`avr Jڦ"zF6s:4yϩnҖ|Q_A]/f; .z$G&/2K5T9KwA;Kh,W7)*@E-Xj|5cfiQU/J;4V%Q+2c{.6zcω+fɊ+niDm@lFAnd/qaѱUUWB̪>q]07>w+ohюrKQUlاӦzcL 6m‘ķߵTqJIeޡL*2דk/W:_-UK jQun&|:1)2PմQI0DsE? :Hna77*1JB[Zt(Oų%xJ>ScU̵RN.54ԓ-*<:2QKϝsBb1>uN*\@L%HfSpuL *fV|PS^*hPV)[.v hP0<ָ%!NIfw2HƀnP͚RuY(s +$ y%6tBdbSA@$i@%9 bB-BΒS;JSs*V Ӊt $m,ԃtIMDJpA4^8Jd% @1sIr ^vF]R:J2'6鎀#S:!BU(^ur '2Sq'qTFjNa4!v]n5i923laS{f]5p}-L6pPS?fL6*0\ 0 lvgq|"&+:8W/ts)t,zMJ$VY:',GI#Ta U9Mq;Ħoڑ$h͆ڈyS7z4eMͧ-Wdg +;an>FB4YR{*ؒ9l5 KQkU٣io*TiSgU*iVTMTrs89LkBs4 ,{RB><6r;)Uӌ޵Z覼 & =-Rܤ#(eS0[ҵ>fX*"ӤU.ImIRu;^3[\ó*Fۨ1J]ͨ ǝU^%mCC̮){UiM[۾p# L - ;#~U3rЭ85*oi碪Szk:O4^U)UB`yx-!.CYSM0PMf(UJW5p+xJMcͪKnĩtU!Fˈl%s ܤO^pk"6 *3M[NioM476 qr1g}!M%cIuY>C0љUqt}Z<6tUʦZj.%:Qm+z$7+:٪&&o֞ٺ.}=87M rEϒaWVUЭ5 ` Rh} S<>pMIN5tNs'Kz&z_IQ- PFc  /Sk@\\rHQ%t-'t6BPЅ3;*P2 Ӏa#:u.f[yt"0ARZ@u f]Mfwmp8b@U9(xuH[JR͹H(HD&Pbxfe7H~i$'Q8 w F B_} \ctH T%53SKgî4 GF avg! 1[>X5PVY#Y3(#8iT=z} 'l%MMW[bx<66ψSjylzjookۚU0}zu+GsۆW M s2G07pXi#1Gŵ%c:pȰΗBӛu*Vk^е-MCRrP*Tew:hrjPlQ沬b-RsX5Z״hL<ʫΰZR;лCw -.7=ʷLVVVo,FU'DfWa M T 76+QT{EgޒѷQMtq>wmw{6ׇVSVdQupzT;ֽ2U[iԥ֢w )ass 3p.NgqE.܆:W_7ÛdV9+V'@2z3C`1mE+z;3Tѻ̲PfNϦU`bbTUdJś<$Lp1~b\kmztQ^sxS~7ދ֪n[N h@J E rfǴ%UMURq$e*uõlJPK@ͣE=ZVl.}vXқ2ԔA:jyޟ>#ztGj-tJ6m>njnW W't&U$/34UUD9꓍E4c:pvz%ڑ`LWJ4fF&mj-Rs@70h~"i%p^0[<+֨ת{G]5fuTRq>[պJEK}FVǃV$BæKωڶg[p;A7ǔ -IKܙ*a Tgٮ W[ĪI"RSS6UL2 3;a2CMV3R$HNaAFldJJmiRYr%.;1I;9ꤐ%x76Q1ىRL$A$ seҴƈY %:q"f]D熕+tbsQΊWrl- s/5O2asHL%$B@Lh^^!D)tވN>a 裻"\:,J@ٺ4P:MɅ-G$~W45RdN~sspgwZ30BsMrYa#ZqRiS$:c5pUhkǼ Sq5[89A],q5ZYC5^2= ]ɷhZ7VOŢJt4б7c/pLTssnayP\XQFwRbӯ)*" eDSNɎfJѭG 5]FG8ͱs^cX⦺AXRduTWFXM8=Nj4+򰦙U>=^g`Zkir&bRl μ7Ul$cn颜\*q)M)&LM\⌼9KWMSͩ\$1ϺatW+XT=TSw 04FZEjyZ܆P$Ϲ*wSVuM4eUb7R[qC9@V K٨\>&4iER ->TR*6 hUR-'<= بHcu6eI7hҗ?)SS_iUU厉۫flUCשφqi6r*b AŲIuD Z^'r8 ΌU644rb:Vyx8 LX۱á~wj pȺϛ&DL좩z vbUzl}4\̨ꂯӘLɋ(@5clOŮބ[ugAI1Ϊb`J< LD)m %!<6Ms莜!H6դH1{Dö\X|OjT&gSu(UUDn0!y7QPor)Ԝ3SwDUks=ng 4BAc'ק 'xJVk=< ZqRm~Sv-m*kmWL'M.'tͿL-ī ]:'УQMOS= Z鹽KXN5(af|3v jSîkm'}sg&0ӎ-H&%dK)%ͼ\zmRdٕT(j9뢪Z+=Z6TruN^&+xWZ ;ъ٣*'W<#~Ī>̚p⩺K{-4uf]2(Pt4wQLN!a.zt8K=L|^4q瑷:]kٳ̮[ul85`,G/HRLUMHq9lt .lBiJV]3pq*T[pq(uUv=b¡RTƗf QgE6 jj4*Zmu`-4#0WlZT8PyQb8}1Yṡ)3aqʫJMQ)MoK̍.SURJUC4krZ+'xw]ETԡ1cv9Ji.$s}Tǜf7*eUNJuyTUZx]M#wČe'T<pf˪jB'L.Q::q)i`ZSU*OkiuSpvZqLfZH ӕÁNJCyJ-MOyR|T=y_r2nXc^ JuAKNZF\Ҕ2eŭa֌̸]J O*UW\ƪy :+U-Ssl{Cd=rK'E):f.7 P=(}jN[NNE5Y:Z=MeTR^}nv}uWc(U̫I7QCk/dZfjY&j7 j} 1Ѵ"v3Fe- A^&I,nĚ+ny|Z2ҕPꦉu5M+Vއ&MۥHxh1%U3n%1 դop/mFU ;S/wNɌ򴒡|sf*jr^ad蠃ÁL4uL|YD3Ԣ΢=Y>[;%ky%ÔXTXZJi%ɅM7irCчNY5^F-;K[ļDm|P-^Ww#vg;,9cnTEy{rs SLtRlcbYypMSKdݢ\E+t-z=(ՠEF˜;Uz k_:#)][-nM ״l,Ն\+貍1MD 0ˊ Ɏ?Ka 锡\FKs$EuҐb2h&nIB`d@WzA^-I]y΅%@9^hWG"mʅӰH(ߤSNdHBS|LIƔ̦e%0 r'a.:B5.*3k)c( p$F{ԩ2P (ˤ[tB$B@u97f$2ߗuU' $$3&baN:Y+R˦H RER5T0Ԭ2Fʙ:s)MPRf 3ۚ7iYJS$unzEϪH}+W==UTƐ}3`g^ճ﹗Jez8%̦Vt1rmcz .lT'tϟƮCW0teV#TF%Sej^w<]6A\= :MLnegCnN V`[0c+sCIͰ FLm3#uS1v*%"@"{. S8<BV8/et) D̜eJ5b n9z#O3mٯ&XJ Rr!$)Qp&լCr6 SMCDPU!:Bc:dˮ@ t:Kȉ^n](. m2!yvhە 3!0`D/n[\/;b`1 fHFYA9 d^[)Hu7&dߘ&s[I#e<:'yx"7Q>gT,@RU'P{:Ԑ"$H* ȁ#UZ/KDVK"V F5+.lܨ[6^lfésb56p%W>W$ 5Pwju1bi<ԩF`eS-yUNfPi>QN͋Js~yt66UNC6*y*U5pO-ϡMWUQJOIr%iS4hS7ES8(61ik~i(mn` r(XIЋf*nRmRBpU]@Bl e$h=7Re"$˴L*A V7Q]H:KMLh#HN/LJkI0nT"E@=b&Sq y0 l{% '0e W@D)E%1(di3t iRѭo&dƐQ 2xh Y6 d)&Iu' *JnL= S,td2B'')s]KdD*XwMt(D&@M̼)baL (rT e^uƩɐ\F^Ge.u3gДBZSᰲewqm3rۘ1* j$ @\uak s$ҠJRȁ:NUfZby2SskTjmDBwTNk]]7TN`?dj=gPT$6 ;5nae{;V+vYώbkUP]Vӯ"Bګtka8>sԦSƭhJ=jfqcIZJ4.9Mlg!QJT93{sd=2.HGr91.ُN" &5օ($0Q|w+Fna=)P Ri=($@ P4866 Ry6@T(`0= /)#0dFạds  )L CAM!A0Nn5tt%<5)"ƙD&MIpHZtQ$њ@^HL BjWS  3>CHe`$f+ųe#DT@1&,&٩$BĖ^b`LDF0/24Cѩ2GL=hp6H ) BR9tRY3**|5Qj1&xѪf^T2mTU p@.@W43(lR͸$nR|PY@U *΂M͆T20 -D4J-i*dJכ*I$\]Wlqrԣsg& *kP@RO%Z'S떔K)G616JYXgRJuq]7Y4LX1۫L2ZQhVZa΍ݖZu^G$,]K)H=E;{(iuaL~+WfN61jmƽK XȈn!H6Pcf*]Kq(ǂaLΖQs)DBAFC* s['IRtL7RuR xxk`LHRʶv L6 ۩*`H lf]r'2"v/1'Ɖl&3)d) x3@3ȼJ)AxS*aJV9AeU?`9۵R`e0:A^ KBD  rLE ^Hit@sA  VhtJS8 C8SBn`c2QUdN-y7 ]1nvFY[(Ii'xRU쀐5PJ@5d(k5L 3%1U`P(i ʭQ@J\Z,!ꄥy6D UZi/٪udA9̴]:y{qСuQyeܕt^3bvE̾=v<4*ݧ~ DTvݡo>d=Һ]iN‡,MU'Z*m6Gzy 4'WVĈSuTX7UnHնljg5z!6SS6Lle(qbͳcKHclh@!crRyR4I) U+MT$`(p9gdr"*%4œI:Έ^liP &餀DBuJ%%@JJHIH'xkr nU @^I3Ci ,U G#@"I<:'A5-$ I3p"N(R51&.` 鹲Wf+ۯ9,H  D0O2iQ Q"dǒ$%ᩅٮ s# 2hF&L|SFZ-`UNL*jX/ۦ+DC*O2, Χ7<)6R勦T4ȣV`(z]S9JPFuR$. W60vbw\HFaIQʏbh}bmNyʴ[\U u4W)*~+ r*|o5&GjST:5];+-[ )4 èq7AVhRZ(KkE#tpnIFUݘޥf2F:xh& 'Djs-SY*Vʶ@P dn"@F+Z锭%cB"} :V49'H@Ll4 K+G*g?-HL(:@HyI&(PExd$W'/h3%6\,$u: ]t tHl&s B&2<脀̝1tE<@ {k*a<2cqiRɰ7()WH ff%=!DKj"%:?4"9Rf`&AeK3G@ #3E|1pxB' 1Ǣ) vnkY2w1 RƉΨ(FE]eJ CZ U3 r;D`rla.FmE\ǎ\U'\G{Xe͖ Z]Q)B8 JTB\~V.PUuF'|o=P6 5.w=zEǷ8in\CW~;UT.'WUm8 KY\hUh EmTmIU:jzlUsLVML +de` paqJcv$Ŕme0S%(UzD$k#Hrd &f4)Cr]S4*FT&D7)@huTS͓@uFO. ).(_7=DP=L$$){T@%zE%+ZuHb0 1Maqt% 7Jl8M&@ 0KMГc{nDA4J7HRD2L ̦ #a:IL߮;M&duӎ7@ 3:lI6)=hФ\BMTB@c6 2!8iyn؇`"ti)lQLX 6TNDL@LzWkHfl|9WvD\H$H*T$H ˺eMU fepZ]C]p뮎+~j7(T2iR^Vs+S>ƯS0U:ictnOۚzobUzvebTYCOR@#fn L^CZ4)blnQ%[*ʖeI@)Q7e0ӮT-@hm5GL:$ P>stream Adobed     '$''''$25552;;;;;;;;;;   ####''',,,   ####''',,,   ####''',,,""  !1AQaq"2BCR #$%&'()*3456789:DEFGHIJSTUVWXYZbcdefghijrstuvwxyz!1AQ"aq2BCRbr #$%&'()*3456789:DEFGHIJSTUVWXYZcdefghijstuvwxyz?<7riVr5 lc$CewgLSXu+ۆN* '"Rg)8 7맠,a%V+GCoΫ/9keZ6N&JfUD :I3W˥Ѵ￫˃zyz{JK@r:G0_4b8Oz}$1E l)P͓WTVÓfhf{L;߿{!zΤb* A zKx)l0yiZ_˲"Yܜp|V7 K]/ b2Jߚ fWgA./cq$2XSj-RXz`4JY[.#I2%E@^+[(B.ЃtR! W & ءB0JX!6! G I\ 19mcsl$(B@^t/u(!\"D\Q2P!l.C%uۖ ! I͐ƪ+!B !tOo4.#BB֐9PD;.eJ't!K"#T7B@ƋCMe $!B&b-bW&hX!B.I͡D ,!B"˰W8XXBKe&E(DB/f%z%vW$!BD '(`B(Bb7 \B̡BP\&5 @FʜE $"׹Z`*~/Uo TMmGJ;U4u[[M8XnHb=Jؕ>4|3y, !͑3dORe5ţ=@Р KĄ.4 B/,N#O~-| :>^W$/,f:겓'csK hx)KL\^^ze flL.}Ax+MaLS֘##֟6MR\1Ds2B ?luW ѦցaZn_˹Z ;g2=5c>b/X|,8'^ur|AGEWbG;SC`8 cZ$d pdēdZo,*sd!0HB@ViLBU,;NךD(!Ky 9ܳXXʄ! @HܺXʄ! mlc+ڵ Bgx MMZH`Ri=fml@ j?b h}+Tmav8K^klaL!A .A$3! FH\3 2O"%dbЄ!5n{LI9k2 /mL/9ڤx&M<-B(MvtBBAΜv3O?EPЃ.=9@`7AI/ph!ZȧI4wQܷJg[Ȇ4\zRp'sB+&Lw* }Tӥ8A}Mqڀ2ArCUsLEw35I>Υb q)L~CDwX"lh %9 $7 R ng-#eΈӂ*L$6hi0%+[n6 ہLZ[prS8ی׫u<`a`7=t?5#t=,FF;;/qO8QZр &fmHpJQ2Vր B+t׍!! nBZlЈB΋ 5(HFBj!sp'r,"0e7.ms޸my@ @!BݷI;lRRB43~Olwq:MY0.:hHB\HE&#C]EH"HB4'@C74JqUҲP!yd.j1a-v4)p\ytj*YS! A:PpZD W!]U0,Mq F'&2aR Q 견azeE G'qG^^iO~@Ԁ}^VysɎtV#$څ7KưqMedN'ǃh$)dtLVppY]%oɹ30RuʮXmP\ Gb ;靪s,*bZ]%j4O )e5O>M]<1&+֘YX! m gTs2ΈB={kE0ړuة¬KE3 F'}UAl<޾ԡ=zm19A9SL 㲲 R,jΛ+nUaL7 sSpcKfy^(in-;96g;'h)YC'Aԓ06N,ٌk޸:p\H4.=uʽOÄe ڭrL D̸MW,AAg@r!;,L]r&WYrKdkdQY㤐n]rlA8oq&bOE*ar7\d1S Z\1.nWJb)pgP\ӼO31\Mn!v<ݹ<}^ay5Hoj^ቌ7k٦Yek$ܮ_͏1Gb` = Q47M\%*!kBT4H"쩖 +B&ZZFA* $ "iTj8 :滷lU҄! /m}T !9B:Z! pӡ7ޒcA!(#@;:$\LsyB%N{(Dؐ |h(! n{hG}S !`!^5o\$gƼ'#y (B#rUEa#;;I~Ȏ8([34\>eՠqD K&鸸r lki^@[W:I$P[^LրnȩGf u`a;nvU<)Woʭ!Ɖv@x7 X0s2< `OUh9Ǔe8wW$sf1q7I F)qq`o_|Km14W8f2rrOH0@Rfd3ܘS-ՎJVaJ$^)\rേh*f3qKߴ mM.ĽT[66[\/1ð{GTyn;$§b .ŭlEUqfSr!Ѵu9/3:RIB8e|$$6Fb!cdN1X Xd>L4CdFmIxxn$0AmYB*,t9q($aUXg1M\\fݱA7/.ϡ<ă$ $ӡXB1B 23<)1/qp:Xѱ0 '1hP~9q,+_E@4'4SΓ1c&Z&zIzgѶyw`|Ӱ kT{˜sq .Tf8kŰfGHAVܙh'4Ƽppy7DSu&Sbf!yEqQna aڛN#QUp< :.w-&`ɔZysݹqU`du^% qq/xV:-k-C`!Ek +.]qn2 $ s zX~3[Si/hu#Z5y~!{ppIsxpy#$к鐖}Bl7JVJ\#oyBb@L֊0H1֋79 uu$ H9A)3)L]v+2ٍB~7*l8ѲkEv5dYuZ'cY g0\ @Fơy Am;&I vŔHUq82[ڻI_'kODiWO;#\7ZyI,tOV+Fb8aisqu|}[MmMXq*-\9h^l[q"SN *\#?4 9qilV xnqkR}[ksr㱜ߚ%@Bs@!\k핧;pt=@&+!BY&9۪/qP(B˶a񮍭g&d6X!D"NhFP!vw](ܯc+86hB:LȤ@$BBiRA_) TW_ %6E-?-r/n@֮0MD6fFib޼Ԑ >U`r|A9]97"5NO,O!<6K *|Ǜ .7Yy! k(' $8r͚κFWP8mXqGħcr _.KZU.S%<z=*h7/ħuSȹV#k-y 'x~6bjl )+ǞHd{E vPs!m/)uܮCȹ$`n;칠Z:Ԯob>K[#b,lK-dq6G޴O3tkp:di *H<*= NDRr.ysWpu'lPW.L.l:]'=3\h"B'Q&37Qմ`=ډvaN֤jꘂE0u\sQG70= s-K$6\1qM%ܻ }?M)Ś #TiJaijhAZd:pwK%c< *\ˬpXluN+̗Xn.)"^Lq)8Jl ^Plpֵ euC3cd`WǘĶ8GYO %O㼰oec/)j:g)D#20w8,^US00aFזtBr:԰''1M$ŭƒ6 zt 'GklOOU>+FkP`  d1uĭcKc 31(ڍ`(*P<)Aθ9& l|!H;b2,4 yyѶO <,Yi"url!NptXdA -SeS0 "5g@Moˁ<˒&!k/] H'O`uM%\c8.dR~x%W伱P`B柙\9ã@{z</r Gqjy.O6L1ę ܒc`+ x.趭2$#YTWX)qߔ09|o6r#328&zXz:#ʖ&W I<rX lx5>gC@Qpent[[^l8|.TL!^rNKe׎D`"^.J!/cըŒ=ĉݑIK8wSEm2}7Sṽ?;L 4`FA2zʮ-=7Xx\C;ч3\ oh$:$e~5&1XXZtbcbQsK,vyoPVb&uI=bkCDEɺ,0nD P  pY,RBn7({̛nB=d6u&sֺKlOQ!IΦ:xZ<ݲni. #*NQ+<oV E⼲}%OLJa#E IHFl<8h %Hwݻ1(\89V#\H%=U8xfq[?20WI޽#Uoi2*11ɥK:[|^N u*889\zHmrGs\# .*+NBXvuvc;4xcr@CaiAn F]d:F 6v'X~0ԭ G4 G:+<r v2K[ rE9>#YolbrNXR/m+P|gLH1 `5"(vE'^ (]^6n\q:#*&<(DײZ]ʹ9@|E-^yFD'NмHEƒts ^;C1!F:J1HpkfU^Fz6 bFsKzF>Mg٤'KV+'[xOrHJu CóJ}&%і䃜dǚSM&!Pcnly&`EzIVsl:w}%ovVKs]T5N,#,Ωϗx(dmV5 !d0 9Cy8,qp_ʹ`qܣTyF  :Nɭ bc%-9(3 q//qx`Y4Mq%@ih߁S#5Rs,,A@);_PQ}vX D+{.;ңZ@igwClCp@ (!\,%ΗeѨ$;<#ZD/+!˂B+Ipp; {@2v߂ي CKsq0[1@t3iNJ= ]yV#r=џQ$[N͇ ?#"x[^V̄ڸ61fKxpR: x9źWI %$\ phAL&"o';(W10krX< IIkrNP5բHZ%NGf:`%qsPe&sTTt4 ;RQ4BqFP$j4:J7yC0̠ "U-~?,3 ת[,<1Q_d2- rJVkjLJnnY`I8 8LMqO0Xy"P=ן|s2ruly^$L,>eayu܈׉z`.9'e{&AU<.M?bޑmB= ['2.9 YfV nJ`H$hyI%gr0=R{0^yF f,^FMp$p⽑%4u juG"88\ wE}Kng4CP%:5K]:rFGC5P`8d=46UsXb1궍a Qv*wx=4vQKKۋЖ 0sMc}b v@ zB:2ܢqw$nA$#eLl<6{8-?.'vᢨ=Ϛ3I#> xins$1Wۻ%9s[O³ e 5M:\ Q8;¯q8iSye^Nz {;t]hm\/w)sgL~ѨUnST6{jmQ=멹XZ.! $Ǒa?EiJr9$s)zNk]!(ۙ:/9ras@P!72! ;R"$_3)q#T!]lkX,reB[%ӤdI:[\@ !BT* 8'߲)ܪ,'_!E1[?2b1}r-:bї RT6Ֆ3yq.\vPN*.'-J^y,[!J6LBL;+0ˬ2wfuBpd&IFױթdlKJ9B$ P}(b2HmJmNa!\x[*>VvEjJu џINFt4LcGhnu8Y7bu9V rdƴlu+Q3ʭiAUx[{S34xPv<4W09Y$ J]VLW.07;jȱP-!B Ȣϒy2KX7HpARZ;G2 g0Qu' W08`Dhس3hg3MNr" 3~EcRʼ{xvxzq^dJ%#[i>ȋMm6 7ٯbDw*<{LI.Y%զvݒ A·}fzi\uz[ψ3M][Ҍ71$p»BaFeq\sź8P=W*S4K8ڧ۰ʰ zHéUÂ^9UK|f(JDp7G8w yyxp nkMÆӲsZU"BkD94:4uXBvq1?qRف9@#% SN cg۲Mv,:Fp8~crM0]V΃''bq={kEWV%^;88{(=4:iFl0|{HrA$BRds h2Ggh@*vPq <%C g;f.x/l-uimNI<u=2JG.rr@>O&cr^L 9D %sO&W&t U<-7]N\I7\]ʌ$ 8H>S.pwn;N\N3FB nϝc$WyERO:4;Rw'z C3Y95IwWW܏y)5,q ˹Hm_pHs3gE2\Ɩ u\9v[ʮ٠9JpZRis6CNuLI1jv4C1y~0ç+@<b0dja\; &},^Y4v+*27p=LB4F) .ʩ V^@ϑ o#>%z+/@;DŽmvp#LEGt$'d" ' #h<4'`O&G}32p0=Ev8;Rq9CޛT:BdMQ0JwCIǤV%AVXgsB[~|&Zgk`4 ޘ5\}u$ ?*.%Y rB3qǭo/{Ԛ1G\׻%f@R_%;1f+ 6#܀tn|^hïc֒1܉0k81,ӯ2O|hǟ [0aO7=Ӽne*vDN}UqHּBXz$5!EBJJR5*.2N*CE2[!x7 D͒-(LJ hB 9$C,:q -'BqH ! 3f9&u HUe9a֖Í$ 66Z2ERx"#D!'@牜arSwtBBv"/v Z*f]w/+PsAjS{v+ZlSv Qԅ' B012Fƈ; D+0jD7V>=[ Yؾ T̓L\A@y w7؎n#eAWSXG YG "OMy0&bv'nհO u$F7B:aӵ1ܼӐ 'r24S"n>vZSͻ.&4{b~k7}%w`@D^\R FBIM~Q{r.xk'r#0;YY I=m8i"Lc:pz~NRn;&j5Aq q< Tf GU..i-wX:`}ZM7+f!s+ֶob\##ZӒ>h"Eh>HjVcsk_g\R1Xׁ$j6EU^ɒAElkt&&kA65JRBo:%C/GUM`P[Gv)i8¶}ig#Flr9tt[w82RN92,3 ,hh;?4y6R׵sD\&gXE~+SODb}C4Gu* In $9G82|K )OsE xx3 #uSij4; w?T>Nq<& K弃^;^"`g+b@63 G˹.a8 [Sy;ywN൯{̸ꠄ)@Nv8 RʬM! +$Ni" D; %JbUk<de1IqXb ԥi(pOkAx 2tQDx8C@I7iȩaޖ4YQ{&V;[#hl% ΐC QbB[$)9OR/9hLOkE: 6xom~ȳ(&B́X>TciېB M R!]n (Bl։QBʔB&)wƫjHB%d湲MыhJ$ Y%##Mms'ml8ѡ P!đ~I픻zIEBkJ$ d$ā9RdESAB$$0D.<!5uq 6":r F׋)4B0xF♰8t1:5QgrQљӡ;qU\M'Ьn@OMbkЩqkۖUd-' {CIp9~6DeE8k%kqq '3c7 Z>E&;K^7]Z? &`hLq::q w%ZnW0[ +ԭyʚ@vR A6xA` &Cakoșo5t{QF/&sp\HE3 a>)kd2]T\h ʋ[Bg.j?)`@f'y' 0<8ۦ=P'Eഴ|`xv/=W XS{Xg^dS鬵Ns]5:t+wƆ na^MsFY\~m8sX2 ^xkZorN+m8 mt:9V.1yqMz.\H93يeζ˓0dW(r~Sʌ:H1ɼO<(8WZ-Bna*[|6ԏ^#&v)܉X]-'&*ܭDKa#\ц͸oC)v\RELT8xf0wa8)N6SV z8^}i]wGJ 'M!927F9sܙUc8ʘBnJm0rb(S͗Cl &5v ȣԜ^䜯<; t!kSUEQqk&*g@UUUT+4+l/mp]$|>Lb75N W9Apx03Y;,lWE1%Z.̕0GbCa< -|φ4;5#?  "ꏾv+!0xLB#s @P]dR)k4[l,f<"wW lV o4ufFzZNU.+RA 5x+@H*`grr2٭;y'(sҹ/N{<.k68eq5 Q Bjnedi xtU5rq-5UA kpGiɘ\q1c#bo[NX33#044ֵxɱOfTFO0|Sf.f:j[H%FJC –gzڳ9 0fqOthTS m !آz2fdI=:;5jg!ȦZ"Ђvm)jT<E/q.;րlUD!{`f:ЊnQBNf/ƍ`JS!HK6fyٓ)FKq%BC%6Lo ELm]A,(Bցq8VB jJ/1jfےLswUXBH;dpYB/l̕l0LܣB t$*CzG}*)!Bn.J5! '$6k%tX!@"kL]vKf4+k @EB%ւz%0A3ƉeaB 62a`!WlQnā !HZ$8%x)GeU! !K4A&$?dSJ/om>ȱOBy7k?nZLn~܀Z Hv$JXB;e(I-T!tBA'z2]%BIC6 ckifF"!xx\^{6@BB %+ &i8N$)@j XJkJ$v ģ.@6YLЄ!!t"r1Hg}šBmUʛ"鳌Ve0!BmPGDV|?DI4LtY `␘cSk3kXHܟ$ߕ2:AHpRiWpCd7p|:3[NL"-&bcBKFIZZƗ 4qx7UDt۰W6 cpǘ+aVͮHɳK`.atSZ hMp+LA6Q#~RrZ5| 5j)r͎]\\R|VtBo+ szb0┡Ӥ`3}SzxF9KV.`$F(W42OW˹V3bHA&34ckLc1H ;r 6I iĄxWI~ȁ(-cv[o11?n@Ѿ5BX$ VayY\#BRB`LHeb!(sH^$B!^s\yl]9%J!eB,]2kHIѩYR0tB]r:Ib,“z! ~RymuBڠILEFRiuB7j햙'4B/8z6%.$2!a1Bx.7&tD$_Y!LӮI:t d_ (gU8ʂS*9Q5>ɒNJB\d[j0S+x.'H+kxDN)tLDX1d2MjN\p.̀@a~z. bw0ҹ2+oȧ z'NAFCF].<:yS Wyqt:i;Î^j66-ȴX %-FloܼeuI(;D z^&3uPs,LpS` 89kmA2`"@˗, P!%&`% + R !$DJ!6U#5B%$uѴ hBdX%XdJ nD EB 252ޔXQBvREHQ6! E&W (fV!I.H%vPtEċ )5BvрrxINpb%N!B@#%:DvKB t`,B#B"5"/yT/b*n&seYŇ6B7k?nZ F=L~܀ҿ Έvn(@IdhBrBHw)! OUvH0"$!B!tB t7ړ~ƈB+֕ pNHB"׉qh!BD#TDHdEФ!&`-(n&SBmҮʍ0rH&0@=sm;Wܪ)t lԀNI5BNl9t4$ dĩJ$^36>j%Y !GׂJ6D1Q8!1v TB'ZOgE[B. 1&r :9Bk4Ul4 =5yـKLdt>vcrc `MccQ'VH )s 2 ) BmL$j.%ۜOX8.'٬|jH]<$ݐ FTj* &d\[r\H;S6ܰ!*yv (,eB  ^iD,!BAGW B62*a.T!-Ĕ!^r昲0 e B"n9]ܳXQ(BE+6XB.b6HuY!CQn(-] J`B!q-QI, !B]u';-YY!\h(^ĄNO)GT{⃯T-7k?nZLn~܀ӿz@7/6!*U^`!z@"iQ5aB3]DDCI!ٶM&rĉFBPj B7\3\VB +Ǎu'RIafTŔ!]$#4@ȎaH!BM9 7HЄ! 4 sFdͼ! HMafP!4R5BsP!!]Ǒ̄!d(F(AZ*:L:2&aϒmd-[Ò:x)CTud! #Ko1ްz7n):o1\\L:6?7_3IHӮ laGl)jM,Zq :g2oi@āDm+X)v@Fq-#C +BQRsF 5C@;TI$6 ͦb`iD@!YJ3J (BYz/@ I8"᠅Ǵ!@"! nD2wdh r! Wv.B!rPk_zXXB. );8!p^Ĉ\2 %Bp&5FAC R! ܍h䲥!+jO>ȦonUؒ{iDQ-bۖm ЩR񄘶yh$`Z! V I1Bb%u Y!]tuD! GQJQ! @DYwhjlfVQB UTK{Qk uA%If7XV'+f. qrh`Z쮊@(Iw"%d!D`!1D!^1L(@CTBuO8%0P!6sBFIWK#-RUĩ! #;HƌIPJ”&uoH#rwVfsbgB&PbxL*25 SsmT&)]vvTح`|Ka"sN ´>,D)<>{~bfԏf|~ADKOkcO}[u)X! ƺ G鸴$N2hFȁRȝ(J^6&wknlFΣjIOv!%LR Q2D)fd,!Bmiv"AP.!]V :%9"TIB&(PB(ʉ(Bx{/5,J.6`1(Bs%d!Bمr"66]1+!vI`  B2AmdJʘBB 9J=u 4Y!t@ Dۖu(Bpq&uųsRSBܔ?b87b9By7k?nZLn~܀К/dtDV "dBFk(B|@\ZG!c*%i]I+(BH.`N-/ad BDšvˈ^]"P!t̡!tNk ! B,BCD/$dVAB\O$. $ BI̥OqBk]rM'=%d!QLj79ޟTlfUn 48DpUaEclӹ'kƷ3 a.*t`au^T-p0Y0I+EQvL+ly1Pin %ˆԥ<* zM)BJ8@YQB6H쉃!8I!B0Q9ֲ)dB D&ezAtҤ! mw*kNB/4LE3ĈqeB Yyv+Ӓ#r!g2Au5Y!]s&]]05ARBo3`݌" D70(BH`qD!BT yBn*(B 綜M3]pFyζ! m >8ˊF'm>ȀmE q!cO~ܴo.ݬ־2, 1tu)J4BI^Ȯ7kj% !fP!%Vر"u l4BQ̑.HBspSfBb3!I %/gBBѐ J.lЖm$3BBE! +!B6BBR,,! "/o\&.&!L!BE$䔫JIېT!!ShI5{qUL%**ABzhΐ׉2Sڜԓ:EMggQހ>8pu+-m32L,Ae | "}֏ +26"T=՘/BNI3 $6$'h,jTTd8ȼfR-R 3B\L8dSB7pC!KRAuiBƫ+s2!nkBAt(d!B (vtEI2Ka!D,\2^Wђ.Fk7.Bޓs-$Q!y9#4 lɱE]`Blg fcPP!t qb]aaB Ug!Bˤ(^ĀW| J"Ksciۖm|01Yr׼P6 !1TIAq-[n#ݰCu^B"v!JQ(BUVQBʼKI]Br\zep:#U!\p:.hrY! ޹$ƋҊY!^2ײ2 u!,7K86N P!&&hdPTE )! i0k"o:%SrllEd"燢DL&Oa7HW2J5 M01)Wj~Ec0897"ܟ_ &"V|^3]0pT.G܀R{8;i|3˱3)-p7!;fV%iXKf62F2 AEB 4-2aI`BX\#m`1ʁBc+F]5fn!]%xCE/B 4\ hEp7rB c9FDFKBy^3]\YDB ȃ*DfdVABE "f@CvQB %-Ŧ8Ґ%p,BD 3:.lXJ.]Yp4 DB.B&07~ȥpC$I-cv[o1gж QlPx*_Td/0BqpgE\ hRB,G6YX"!zT7`2^B.]tn+˓xXB.4C3\ VP!vfWļI!B]xBY9"퐳0! NH`năbeB ͐# 'zBn4ݲqIֺB$*6LՌt)!ٹ)! GmLe)!Нůdy 'TƋR?IHV+wQ_4Ӹ(|vMpm7!dLy 6pw,sNuC䊃}ˎPG*cJR%Y)a7E\V4KP+ ( +4҅$IĀu' pҰ!9i%2! ,^FYM2Bs:hd&^$fpMY搄!th\qWgv+! qȶ"J b!]o]`#Dv갰B#] &Ҹ*a`Bp^oͫ Bp+];D6 1BΡ.6J!r"Q:ˆ%(By\q Ȯ꼱j&P!x㴹"WV%aB(NćƿdSnF'm>ȱ4V[1Ecv[o1cvџ8: *j›¸s))+\ ) POfȓkAX9BݕtזQ.,J\(!B+^2!\(fBㅬVABɔ;Fb`єʒ/8(fzKBSd2$JƈB;dnL(KĬ!s;)7ђE̬!@dڨ \M1ʰ!5ޣ+$O+$Qrc^Ɠ*MpS RerrF6 w<[Levx~M"3{^r;YN\9)jfѹ4½`OCe3UAW!IڨAoOli:ZQ\E QBMҀj3\kZ @ܣ$բ"cf0adxK7f B93ٳrRJVRDB`na4+2!\hp藆|K+ġB{DBTTeB9ΐQp  !\tP!J{iD!^^ N#f胝 7BYpo^XXB=%vM׀QpB!"Wd{:{0]1Yr-ېyĩl=^t.Ry(="cxEW*B orx4XʛIⰄ!*mJ5RB /B "J.!p .gPIP! P$i3*'.8(;yQ"t=UġBuBu,B$(BBx쒵:,$(B "I ,8pD%BU@Mo!W^D8 ġBN%؝dnV,ONUw<7'Cnp0n&3Z&o k/ /EM1=C}oY5NݾMc5RtӉ൞jr\W; IGcm|v,Y#h0,-7>-_"q-*a,.#5 y6MwjwM+Ϋ>UW\Ӊ\f8NyYcpZT9]DGȦT>stream endstream endobj 1080 0 obj <>stream endstream endobj 1079 0 obj <>stream endstream endobj 747 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 748 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 749 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 750 0 obj <>/ExtGState<>/Font<>/ProcSet[/PDF/Text]/Properties<>/Shading<>/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 751 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1090 0 obj <>stream q /GS0 gs /Fm0 Do Q 0 0 0 1 K 1 j 1 J [0 2.997]0 d /GS1 gs q 1 0 0 1 74.3631 706.8466 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 71.3661 706.8466 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q [0 2.997]0 d q 1 0 0 1 74.3631 679.2388 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 71.3661 679.2388 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q 0 j 0 J q 1 0 0 1 70.8661 625.1696 cm 0 0 m 453.543 0 l S Q BT 0 0 0 1 k /T1_0 1 Tf 0.01 Tc -0.01 Tw 8 0 0 8 70.9061 731.2159 Tm [(KEYW)22(ORDS:)]TJ /T1_1 1 Tf 0 Tc 0.023 Tw 4.948 0 Td [( pilonid)26.1(al sinus, w)12(ound closure techniq)14.1(ues, pilonid)26.1(al cyst, w)12(ound plastic surg)12.1(er)-43(y with local tissues, sacrococcyg)12.1(eal cyst)]TJ /T1_0 1 Tf 0.01 Tc 0.018 Tw -4.948 -1.909 Td [(C)19(ONFL)-33(ICT)5( OF)5( INTE)25(REST)62(:)]TJ /T1_1 1 Tf 0 Tc 0.023 Tw 9.871 0 Td [( The authors declare no conf)-22(lict of interest)]TJ /T1_0 1 Tf 0.037 Tc -9.871 -2.617 Td [(F)3.2(O)-4.6(R)8.7( C)-17.5(I)-15.6(T)45.4(A)37.5(T)-24.5(I)-1.3(ON:)]TJ /T1_2 1 Tf 0.023 Tc 0.032 Tw 6.468 0 Td [( S)-10.3(h)-7(u)-13.5(b)-13.8(r)-15.8(o)-10.3(v)]TJ /Span<>> BDC ( )Tj EMC [(E)-5.6(.)-1.9(N)-2.8(.)-23.5(, B)-16.4(a)-10.1(r)-60.6(y)-28.9(s)-8.8(h)-15.1(e)-15.8(v)]TJ /Span<>> BDC ( )Tj EMC [(A)-23(.)15(G)-11.6(.)-23.5(, T)43.2(r)-56.4(i)-5.1(a)-7.6(n)-14.5(d)-9.3(a)-14.4(f)-63(i)-7.1(l)-20.9(o)-10.3(v)]TJ /Span<>> BDC ( )Tj EMC [(K)-27(.)40.6(V)39.8(. N)-14.6(e)-12.6(w m)-16.6(e)-22.3(t)-26.1(h)-10.9(o)-20.4(d f)-25.2(o)-11.8(r w)-13.5(o)-13.3(u)-5(n)-14.5(d d)-15.3(e)-18.6(f)-28.5(e)-19.1(c)-41.5(t c)-14.4(l)-20.9(o)-15.8(s)-8.8(u)-7.6(r)-19.1(e a)-14.4(f)-66.2(t)-24.7(e)-12.1(r p)-18.6(i)-7(l)-20.9(o)-9.2(n)-14(i)-8.8(d)-9.3(a)-11.4(l s)-26.1(i)-3.2(n)-7.7(u)-21.9(s e)-33.1(x)-5.5(c)-38.2(i)-7.4(s)-26.1(i)-6.8(o)-9.2(n)-5.6(.)23( )]TJ /T1_1 1 Tf 0.033 Tc -0.033 Tw -6.473 -1.2 Td [(K)13.9(ol)3.6(op)2.4(r)3.1(o)3.4(k)-19.2(t)2.2(ol)3.6(o)-3.3(g)-13.2(i)6.7(a)5.8(.)]TJ /T1_2 1 Tf 0.023 Tc 0.024 Tw 7.019 0 Td [( 2)-8.9(0)-3.8(2)8.8(4)10.2(;)9.8(2)-10.3(3)6(\()37.7(1)44.3(\))14.5(:)20.9(12)-6.1(9)-22.6(\226)50.8(1)-7.9(3)13.5(5)6.9(. \()-0.9(i)-3.2(n R)-6.5(u)-21.9(s)-22.3(s)-15.5(.)43.2(\))10.4(. h)-17.1(t)-49.4(t)-29.4(p)-18.7(s)-8(:)1.9(/)84.7(/)36.4(d)-11.1(o)-12.5(i.)2.7(o)-11.8(r)-16.7(g)-22.8(/)11.2(1)14(0)6.5(.)-5.6(3)7.9(3)-15.9(8)1.3(7)4.6(8/)7.9(2)-8.9(0)9.3(7)-1.9(3)-13.3(-)41.2(7)10.7(55)-8.9(6)-26.7(-)9.7(2)-8.9(0)-3.8(2)8.7(4)-28.5(-)9.7(2)-10.2(3)-13.4(-)55.1(1)26.9(-)55.2(12)-6.1(9)-23.6(-)55.1(1)-7.9(3)13.5(5)]TJ /T1_0 1 Tf 0.01 Tc 0.101 Tw -7.014 -2.617 Td [(\026\020\021\033\030)5( \020\036\017)5( \013\033\021\033\013\023\030\037\023:)]TJ /T1_1 1 Tf 0 Tc 0.106 Tw 10.742 0 Td ( \231\205\005\032\n\027 \230\032\025\013 \217\025\013\n\023\026\031\027\025\ \006, \205\023.)Tj /Span<>> BDC ( )Tj EMC (\213\n\t\033\n\032\t\013\026\002, \030.)Tj /Span<>> BDC ( )Tj EMC (6, \013\027.19, \222\032\026\t\021\n\030\026\032, 350901, \212\n\t\t\025\ \002; \024\031\023.:)Tj /Span<>> BDC ( )Tj EMC (+7 \(918\) 234-83-33; )Tj 0.023 Tw -10.747 -1.2 Td (e-mail: erik.nalchanin@ yandex.ru)Tj /T1_0 1 Tf 0.01 Tc 0.307 Tw 0.005 -1.2 Td [(ADDRESS)5( F)13(OR)5( )0.5(C)19.1(ORRESPONDEN)23(CE:)]TJ /T1_1 1 Tf 0 Tc 0.312 Tw 14.628 0 Td [( )0.5(Er)-37(ic )0.5(N)28(. )0.5(Shubrov)63.1(, )0.5(6 Bosporsk)11.1(aya )0.5(st., )0.5(sq. )0.6(19, Krasnod)26(ar)61(, )0.5(350901, )0.5(R)22(ussia; )0.5(tel.:)]TJ /Span<>> BDC ( )Tj EMC 33.229 0 Td [(+7 )0.5(\(918\) )0.5(234-83-33; )]TJ 0 Tw 8.831 0 Td ( )Tj 0.023 Tw -56.693 -1.2 Td [(e-mail: er)-37(ik.nalchanin@ yande)-14.9(x.ru)]TJ 0 Tw 0 -2.792 TD (\200\026\024\026 \033\n\t\024\205\033\023\031\021\025\002)Tj /Span<>> BDC ( )Tj EMC (\227 03.10.2023)Tj /Span<>> BDC ( )Tj EMC 19.488 0 Td (\n\t\023\031 \030\n\032\026\005\n\024\013\025)Tj /Span<>> BDC ( )Tj EMC (\227 22.12.2023)Tj /Span<>> BDC ( )Tj EMC 18.78 0 Td (\032\025\021\002\024\n \013)Tj /Span<>> BDC ( )Tj EMC (\033\205\005\023\025\013\026\203\025\025)Tj /Span<>> BDC ( )Tj EMC (\227 12.02.2024)Tj ( )Tj -38.268 -1.375 Td (Received)Tj /Span<>> BDC ( )Tj EMC (\227 03.10.2023)Tj /Span<>> BDC ( )Tj EMC 19.488 0 Td (Revised)Tj /Span<>> BDC ( )Tj EMC (\227 22.12.2023)Tj /Span<>> BDC ( )Tj EMC 18.78 0 Td (Accepted for publication)Tj /Span<>> BDC ( )Tj EMC (\227 12.02.2024)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 70.936 566.5159 Tm (\023\023\034\226\034\022\031\034)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf 0 Tc -0.066 Tw 10 0 0 10 70.8661 542.1599 Tm (\215\017\035\024\027\017\007\026\035\034\027\026\016 \022\017\f\021\026 \ \(\215\025\) \022\030\036\f\021\006\024\r\024-\022\024\023\004\017\022\024\ \r\024\005 \024\002)Tj 0 Tw (-)Tj 0.047 Tw 0 -1.218 TD (\035\026\f\021\017)Tj /Span<>> BDC ( )Tj EMC (\227 \026\002\024\035\036\r\026\027\017\036, \b\026\030\026\022\021\036\ \030\017\031\033\013\036\036\f\016 \027\026\035\017\004\017\036\n )Tj 0.136 Tw T* (\022\026\027\026\035\026 \(\b\024\007\026\) \023\024\007 \022\024\032\036\ \005, \022\024\021\024\030\t\005 \r\t\f\021\035\026\027 \017\027\031\021\ \030\017 )Tj -0.038 Tw T* (\220\023\017\021\036\035\017\036\n \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\007\036\030\032\017\021 \r)Tj /Span<>> BDC ( )Tj EMC (\024\f\027\024\r\027\024\n \r\024\035\024\f\t, \017)Tj /Span<>> BDC ( )Tj EMC (\024\021\022\030\t\r\026)Tj 0 Tw (-)Tj -0.037 Tw T* (\033\013\036\005\f\016 \024\007\027\017\n \017\035\017 \027\036\f\022\024\ \035\034\022\017\n\017 \024\021\r\036\030\f\021\017\016\n\017 \r)Tj /Span<>> BDC ( )Tj EMC (\n\036\032\255)Tj 0 Tw (-)Tj 0.047 Tw T* (\016\020\024\007\017\004\027\024\005 \002\024\030\024\007\036 [1]. \210\ \007\027\017\n \017)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\r\t\b \024\023\017\f\026\035 \023\017)Tj 0 Tw (-)Tj -0.062 Tw T* (\035\024\027\017\007\026\035\034\027\031\033 \002\024\035\036\027\034 \022\ \030\036\f\021\006\024\r\024-\022\024\023\004\017\022\024\r\024\005 \024\ \002\035\026\f\021\017 )Tj 0.119 Tw T* [(\204\036\005\024 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC [(1833 )0.5(\020. [2]. )0.5(\200\024\023\030\024\f )0.5(\220\021\017\024\035\024\020\017\017 )0.5(\215\025 )0.5(\024\f\021\026\r\026\035\f\016 )]TJ 0.108 Tw T* (\007\024\035\020\024\036 \r\030\036\n\016 \007\017\f\022\031\021\026\002\ \036\035\034\027\t\n. \210\021\036\004\036\f\021\r\036\027\027\t\036 \026\ \r\021\024)Tj 0 Tw (-)Tj 0.168 Tw T* [(\030\t )0.5(\f\004\017\021\026\035\017, )0.6(\004\021\024 )0.5(\220\021\024 )0.5(\r\030\024\032\007\036\027\027\026\016 )0.6(\023\026\021\024\035\024\020\017\016, )0.5(\026)]TJ /Span<>> BDC ( )Tj EMC 19.921 0 Td (\026\030\031)Tj 0 Tw (-)Tj 0.067 Tw -19.921 -1.218 Td [(\002\036\032\027\t\036 )0.5(\026\r\021\024\030\t)]TJ /Span<>> BDC ( )Tj EMC [(\227 \004\021\024 )0.5(\220\021\024 \023\030\017\024\002\030\036\021\036\027\027\026\016 )0.5(\023\026\021\024\035\024\020\017\016 )]TJ 0.053 Tw T* ([3]. \210\002\013\036\023\030\017\027\026\027\027\t\n\017 \016\r\035\016\ \033\021\f\016 \021\036\024\030\017\016 \025\026\030\017\007\026\022\017\ \f\026 )Tj 0.03 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\021\036\024\030\017\016 \207\026\f\022\024\n\026 [4,5]. \200)Tj /Span<>> BDC ( )Tj EMC (\217\024\f\f\017\005\f\022\024\005 \205\036\007\036\030\026\006\017\017 \ \004\026)Tj 0 Tw (-)Tj 0.025 Tw T* [(\f\021\024\021\026 )0.5(\r\f\021\030\036\004\026\036\n\024\f\021\017 )0.5(\215\025 26 \f\035\031\004\026\036\r )0.5(\027\026)]TJ /Span<>> BDC ( )Tj EMC 16.136 0 Td (100 \021\t\f.)Tj /Span<>> BDC ( )Tj EMC 3.744 0 Td (\027\026\f\036)Tj 0 Tw (-)Tj 0.146 Tw -19.88 -1.218 Td [(\035\036\027\017\016, )0.6(\004\021\024 \f\024\f\021\026\r\035\016\036\021 )0.5(1-2% )0.5(\002\024\035\034\027\t\b )0.6(\b\017\030\031\030\020\017\004\036\f\022\024\005 )]TJ 0.355 Tw T* (\023\026\021\024\035\024\020\017\036\005. \223\026\f\021\024\021\026 \r\f\ \021\030\036\004\026\036\n\024\f\021\017 \r)Tj /Span<>> BDC ( )Tj EMC (\n\017\030\036 \024\004\036\027\034 )Tj 0.151 Tw T* [(\r\026\030\017\026\002\036\035\034\027\026, )0.6(\021\026\022 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 8.395 0 Td [(\230\031\030\006\017\017 )0.5(\024\027\026 )0.6(\f\024\f\021\026\r\035\016\036\021 )0.5(6,6% )0.6(\027\026)]TJ 0 Tw (-)Tj 0.18 Tw -8.395 -1.218 Td (\f\036\035\036\027\017\016 \r)Tj /Span<>> BDC ( )Tj EMC (\r\024\030\026\f\021\036 \024\021 17 \007\024)Tj /Span<>> BDC ( )Tj EMC (28 \035\036\021, \026)Tj /Span<>> BDC ( )Tj EMC (\r \221\234\202 0,7% )Tj 0.16 Tw T* (\024\021)Tj /Span<>> BDC ( )Tj EMC (\r\f\036\b \b\017\030\031\030\020\017\004\036\f\022\017\b \023\026\006\017\ \036\027\021\024\r [6]. \221\024\024\021\027\024\001\036\027\017\036 )Tj 0.243 Tw T* (\n\031\032\004\017\027\t:\032\036\027\013\017\027\t 4:2,2 [7]. \025\035\017\ \027\017\004\036\f\022\017 \215\025 \004\026\013\036 )Tj 0.087 Tw T* (\r\f\036\020\024 \023\030\024\016\r\035\016\036\021\f\016 \r)Tj /Span<>> BDC ( )Tj EMC (\r\017\007\036 \b\030\024\027\017\004\036\f\022\024\020\024 \r\024\f\023\ \026\035\036\027\017\016, )Tj 0 Tw T* (\026\002\f\006\036\f\f\026 \017\035\017 \002\036\f\f\017\n\023\021\024\n\ \027\t\b \f\r\017\013\036\005 [8].)Tj 0.044 Tw T* (\200 \n\017\030\036 \001\017\030\024\022\024 \017\f\023\024\035\034\031\ \033\021\f\016 \021\026\022\017\036 \n\036\021\024\007\t, \022\026\022 \023\ \036\030)Tj 0 Tw (-)Tj 0.148 Tw T* (\r\017\004\027\t\005 \024\021\022\030\t\021\t\005 \f\023\024\f\024\002, \ \023\036\030\r\017\004\027\024\036 \f\030\036\007\017\027\027\024\036 \026\ )Tj 0 Tw (-)Tj 0.288 Tw T* (\022\030\t\021\017\036, \023\036\030\r\017\004\027\024\036 \026\f\017\n\n\ \036\021\030\017\004\027\024\036 \026\022\030\t\021\017\036 \030\026\027\ \t, )Tj 0.169 Tw T* (\f\023\024\f\024\002\t \025\026\030\017\007\026\022\017\f\026, \207\026\f\ \022\024\n\026, \214\017\n\002\036\030\020\026 \017)Tj /Span<>> BDC ( )Tj EMC (\021.\007. [9]. )Tj 0.378 Tw T* (\203\024 \031\027\017\r\036\030\f\026\035\034\027\024\020\024 \n\036\021\ \024\007\026 \024\023\036\030\026\021\017\r\027\024\020\024 \035\036\004\ \036\027\017\016 )Tj 0.125 Tw T* (\027\036 \030\026\030\026\002\024\021\026\027\024 \017)Tj /Span<>> BDC ( )Tj EMC (\023\024 \f\036\005 \007\036\027\034. \203\036\f\n\024\021\030\016 \027\026\ )Tj /Span<>> BDC ( )Tj EMC (\024\002\017\035\017\036 )Tj 0.26 Tw 0 -1.218 TD [(\b\017\030\031\030\020\017\004\036\f\022\017\b )0.6(\n\036\021\024\007\024\r )0.5(\035\036\004\036\027\017\016 )0.6(\215\025, )0.5(\004\026\f\021\024\021\026 )0.5(\030\036\006\017)]TJ 0 Tw (-)Tj 0.059 Tw 0 -1.218 TD (\007\017\r\024\r \n\024\032\036\021 \007\024\f\021\017\020\026\021\034 1\ 0\22619%, \023\024\f\035\036\024\023\036\030\026\006\017\024\027\027\t\b\ )Tj 0.093 Tw 0 -1.218 TD (\030\026\027\036\r\t\b \024\f\035\024\032\027\036\027\017\005)Tj /Span<>> BDC ( )Tj EMC (\227 25\22635%, \027\036\f\024\f\021\024\016\021\036\035\034\027\024\f\021\ \034 )Tj 0 Tw T* (\001\r\024\r)Tj /Span<>> BDC ( )Tj EMC (\227 11\22618% [10].)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0.01 Tc 0.018 Tw 14 0 0 14 70.936 128.1078 Tm [(\017\034\r\241)5( \031\032\032\r\034\226\037\023\026\022\031\025)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf 0 Tc -0.03 Tw 10 0 0 10 70.8661 103.7519 Tm (\037\036\035\034\033 \027\026\f\021\024\016\013\036\020\024 \017\f\f\035\ \036\007\024\r\026\027\017\016 \002\t\035\024 \031\035\031\004\001\036\027\ \017\036 \030\036)Tj 0 Tw (-)Tj -0.005 Tw T* [(\031\035\034\021\026\021\024\r )0.6(\b\017\030\031\030\020\017\004\036\f\022\024\020\024 )0.5(\035\036\004\036\027\017\016 )0.6(\023\026\006\017\036\027\021\024\r )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC 19.764 0 Td (\023\017\035\024)Tj 0 Tw (-)Tj -19.764 -1.218 Td (\027\017\007\026\035\034\027\024\005 \022\017\f\021\024\005.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0.01 Tc 0.018 Tw 14 0 0 14 303.3769 566.5159 Tm [(\f\026\017\031\034\022\024\232)5( \031)5(\016)-18.3(\240\034)-31(\024)35(\037\226\232)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf 0 Tc 0.482 Tw 10 0 0 10 303.3071 542.1599 Tm (\222\f\f\035\036\007\024\r\026\027\017\036 \016\r\035\016\035\024\f\034 \ \023\030\024\f\023\036\022\021\017\r\027\t\n \030\026\027\007\024\n\017)Tj 0 Tw (-)Tj 0.197 Tw T* [(\017\030\024\r\026\027\027\t\n, )0.5(\023\030\024\r\036\007\036\027\024 )0.5(\f\030\036\007\017 100 )0.5(\023\026\006\017\036\027\021\024\r \f)]TJ /Span<>> BDC ( )Tj EMC (\215\025 )Tj 0.064 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC 0.77 0 Td [(\b\030\024\027\017\004\036\f\022\024\005 )0.6(\f\021\026\007\017\017 )0.5(\027\026)]TJ /Span<>> BDC ( )Tj EMC 10.002 0 Td [(\002\026\036 )0.5(\206\207\211\003 )0.5(\203\222\222-\025\025\207\2251, )0.6(\024\021)]TJ 0 Tw (-)Tj 0.092 Tw -10.773 -1.218 Td [(\007\036\035\036\027\017\036 )0.6(\020\027\024\005\027\024\005 )0.5(\b\017\030\031\030\020\017\017 )0.6(\f)]TJ /Span<>> BDC ( )Tj EMC [(\016\027\r\026\030\016 )0.5(2021 )0.5(\023\024)]TJ /Span<>> BDC ( )Tj EMC 19.248 0 Td (\016\027\r\026\030\034 )Tj 0 Tw -19.248 -1.218 Td (2023 \020\020.)Tj 0.015 Tw T* (\025\030\017\021\036\030\017\017 \r\022\035\033\004\036\027\017\016: \215\ \025 \r)Tj /Span<>> BDC ( )Tj EMC (\b\030\024\027\017\004\036\f\022\024\005 \f\021\026\007\017\017; \r\024\ )Tj 0 Tw (-)Tj 0.038 Tw T* (\030\026\f\021 \024\021 18 \007\024)Tj /Span<>> BDC ( )Tj EMC (55 \035\036\021; \023\024\007\023\017\f\026\027\027\024\036 \007\024\002\ \030\024\r\024\035\034\027\024\036 \017\027)Tj 0 Tw (-)Tj 0.399 Tw T* (\235\024\030\n\017\030\024\r\026\027\027\024\036 \f\024\020\035\026\f\017\ \036. \206\030\031\023\023\t \235\024\030\n\017\030\024\r\026\035\017\f\034\ )Tj 0.015 Tw T* (\f\035\031\004\026\005\027\t\n \024\002\030\026\024\n \023\024)Tj /Span<>> BDC ( )Tj EMC (\n\036\021\024\007\031 \253\022\024\027\r\036\030\021\024\r\273; \r)Tj /Span<>> BDC ( )Tj EMC (\024\f\027\024\r)Tj 0 Tw (-)Tj T* (\027\024\005 \017)Tj /Span<>> BDC ( )Tj EMC (\022\024\027\021\030\024\035\034\027\024\005 \020\030\031\023\023\036 \002\ \t\035\024 \023\024)Tj /Span<>> BDC ( )Tj EMC (50 \023\026\006\017\036\027\021\024\r.)Tj 0.017 Tw T* [(\200 )0.5(\024\f\027\024\r\027\024\005 )0.6(\020\030\031\023\023\036 )0.5(\r\t\023\024\035\027\016\035\024\f\034 )0.5(\017\f\f\036\004\036\027\017\036 )0.6(\215\025 )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC 20.319 0 Td (\023\035\026)Tj 0 Tw (-)Tj 0.187 Tw -20.319 -1.218 Td (\f\021\017\004\036\f\022\017\n \026\022\030\t\021\017\036\n \030\026\027\ \036\r\024\020\024 \007\036\235\036\022\021\026 \022\030\036\f\021\006\024\ \r\024-)Tj 0.095 Tw T* [(\022\024\023\004\017\022\024\r\024\005 \024\002\035\026\f\021\017 \f\024\ \020\035\026\f\027\024 \023\026\021\036\027\021\031 R)12(U \2252751821 )]TJ 0.066 Tw T* (\024\021 19.07.21 \020. \215\030\036\017\n\031\013\036\f\021\r\026\n\017\ \030\026\030\026\002\024\021\026\027\027\024\020\024 \f\023\024)Tj 0 Tw (-)Tj 0.059 Tw T* (\f\024\002\026 \016\r\035\016\035\017\f\034: \031\n\036\027\034\001\036\027\ \017\036 \027\026\021\016\032\036\027\017\016 \f\024\023\024\f\021\026\r\ \035\016\036)Tj 0 Tw (-)Tj 0.121 Tw T* (\n\t\b \022\024\032\027\t\b \022\030\026\036\r, \031\035\031\004\001\036\ \027\017\036 \235\024\030\n\017\030\024\r\026\027\017\016 \001\r\024\r, \ )Tj 0.029 Tw T* [(\023\024\r\024\035\016\033\013\036\036 )0.6(\031\007\026\035\017\021\034 )0.5(\027\017\021\017 )0.6(\023\030\017)]TJ /Span<>> BDC ( )Tj EMC 13.345 0 Td [(\007\024\f\021\017\032\036\027\017\017 )0.6(\023\030\024\004\027\024\005 )]TJ 0.04 Tw -13.345 -1.218 Td (\235\017\022\f\026\006\017\017 \022\030\026\036\r \235\026\f\006\017\017\ , \024\002\036\f\023\036\004\036\027\017\036 \220\235\235\036\022\021\017\ \r\027\024\020\024 )Tj 0.401 Tw T* [(\023\024\f\035\024\005\027\024\020\024 )0.5(\007\030\036\027\017\030\024\r\026\027\017\016 )0.5(\030\026\027\t )0.6(\(\f\031\002\235\026\f\006\017\026\035\034\027\t\005 )]TJ 0.081 Tw T* (\f\035\024\005 \007\030\036\027\017\030\024\r\026\035\f\016 \023\036\030\ \235\024\030\017\030\024\r\026\027\027\t\n \024\007\027\024\023\030\024\f\ \r\036\021)Tj 0 Tw (-)Tj 0.188 Tw T* (\027\t\n \007\030\036\027\026\032\024\n, \026)Tj /Span<>> BDC ( )Tj EMC (\220\023\017\235\026\f\006\017\026\035\034\027\t\005 \f\035\024\005)Tj /Span<>> BDC ( )Tj EMC (\227 \026)Tj /Span<>> BDC ( )Tj EMC (\f\004\036\021 )Tj 0 Tw T* (\f\n\036\013\036\027\017\016 \027\017\021\036\005 \027\026)Tj /Span<>> BDC ( )Tj EMC (\235\026\f\006\017\017\).)Tj 0.164 Tw T* [(\221\031\021\034 \f\023\024\f\024\002\026 \026\022\035\033\004\026\035\026\ \f\034 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC [(\f\035\036\007\031\033\013\036\n: )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC (\023\024\035\024\032\036)Tj 0 Tw (-)Tj 0.091 Tw T* [(\027\017\036 \002\024\035\034\027\024\020\024 ja)-17(ck-knife \023\024\007 \024\002\013\017\n \024\002\036\002\024\035\017\r\ \026\027\017\036\n )]TJ 0.23 Tw T* (\r\017\031\026\035\017\017\030\024\r\026\035\017 \n\036\032\255\016\020\ \024\007\017\004\027\031\033 \f\022\035\026\007\022\031 \(\217\017\f.)Tj /Span<>> BDC ( )Tj EMC (1\), )Tj 0.111 Tw T* (\007\026\035\036\036 \024\002\030\026\002\026\021\t\r\026\035\017 \024\023\ \036\030\026\006\017\024\027\027\024\036 \023\024\035\036 \021\030\036\b\ \022\030\026\021\027\024 )Tj 0.219 Tw T* [(\030\026\f\021\r\024\030\024\n )0.5(\026\027\021\017\f\036\023\021\017\022\026 )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC 11.3 0 Td [(\023\030\024\022\030\026\001\017\r\026\035\017 )0.5(\f\r\017\013 )0.6(\030\026\f)]TJ 0 Tw (-)Tj -0.019 Tw -11.3 -1.218 Td (\021\r\024\030\024\n \022\030\026\f\017\021\036\035\016. \215\030\024\017\ \r\024\007\017\035\024\f\034 \017\f\f\036\004\036\027\017\036 \036\007\017\ \027\t\n )Tj -0.022 Tw 0 -1.218 TD (\002\035\024\022\024\n \f\r\017\013\026\(-\036\005\) \007\024)Tj /Span<>> BDC ( )Tj EMC (\016\020\024\007\017\004\027\024\005 \235\026\f\006\017\017, \023\030\017\ \022\030\036\023\035\016)Tj 0 Tw (-)Tj 0.079 Tw 0 -1.218 TD (\033\013\036\005\f\016 \022)Tj /Span<>> BDC ( )Tj EMC (\f\030\036\007\017\027\027\024\n\031 \022\030\036\f\021\006\024\r\024\n\031\ \020\030\036\002\027\033 \(\217\017\f. 2\). )Tj 0.134 Tw 0 -1.218 TD (\210\021\f\021\031\023\026\035\017 \r)Tj /Span<>> BDC ( )Tj EMC (\022\026\032\007\031\033 \f\021\024\030\024\027\031 \024\021 \022\030\036\ \f\021\006\024\r\024\020\024 \020\030\036\002\027\016 )Tj 0.075 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC 1.281 0 Td [(1 )0.6(\f\n )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC 2.867 0 Td [(\030\026\f\f\036\004\036\027\017\036\n )0.6(\016\020\024\007\017\004\027\024\005 )0.6(\235\026\f\006\017\017 )0.7(\017)]TJ /Span<>> BDC ( )Tj EMC 14.522 0 Td (\n\024\002\017\035\017)Tj 0 Tw (-)Tj 0.102 Tw -18.67 -1.218 Td (\024\r\026\035\017 \036\007\017\027\t\n \002\035\024\022\024\n \016\020\ \024\007\017\004\027\031\033 \n\t\001\006\031 \017)Tj /Span<>> BDC ( )Tj EMC (\235\026\f\006\017\033 )Tj 0 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC (\001\017\030\017\027\031 \007\024)Tj /Span<>> BDC ( )Tj EMC (1,5 \f\n \r)Tj /Span<>> BDC ( )Tj EMC (\022\026\032\007\031\033 \f\021\024\030\024\027\031 \(\217\017\f.)Tj /Span<>> BDC ( )Tj EMC (3\).)Tj 0.963 Tw T* (\212\026\035\036\036 \031\f\021\026\027\026\r\035\017\r\026\035\f\016 \023\ \036\030\235\024\030\017\030\024\r\026\027\027\t\005 \007\030\036)Tj 0 Tw (-)Tj 0.197 Tw T* (\027\026\032 \027\026)Tj /Span<>> BDC ( )Tj EMC (\007\027\024 \030\026\027\t, \022\024\027\006\t \022\024\021\024\030\024\ \020\024 \r\t\r\024\007\017\035\017 \004\036\030\036 )Tj 0.374 Tw T* (\022\024\027\021\030\026\023\036\030\021\031\030\t \r)Tj /Span<>> BDC ( )Tj EMC (\r\036\030\b\027\036\n \017)Tj /Span<>> BDC ( )Tj EMC (\027\017\032\027\036\n \031\020\035\031 \f\023\030\026\r\026 )Tj 0.166 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\235\017\022\f\017\030\024\r\026\035\017 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\023\024\n\024\013\017 \n\024\027\024\027\017\021\017. \210\021\f\021\031\ \023\017\r \024\021 )Tj 0.22 Tw T* (\r\036\030\b\027\036\020\024 \031\020\035\026 \030\026\027\t \027\026)Tj /Span<>> BDC ( )Tj EMC (2\2263)Tj /Span<>> BDC ( )Tj EMC (\f\n, \007\036\035\026\035\017 \r\022\024\035 \017\020\035\024\005 )Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 0 Tw 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\033\030\031\030\213\b)-20.9(\035\231\213\233\t \021\032)50(\b)42(\032\231\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj -51.938 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 23, \023\0221)69(, 202)69(4)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 23, \023\0221)69(, 202)69(4)]TJ /T1_5 1 Tf 25 0 0 25 20.7527 56.0378 Tm (130)Tj ET endstream endobj 1087 0 obj [1091 0 R] endobj 1088 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\213\025\r\020\203 \006\221\025\006\025\f \221\007\013\006)-10(\026\220\017\016\006\n)10(\025\202)10(\025 \222\013\n\002\020\026\220\205 \002\013\001\016\r\025\202)10(\025 )]TJ 0 -1 TD [(\201\016\225\016\n)-10(\026)11(\013 \221\025\006)-10(\007\016 \220\006\006\016\017\016\001\220\205 \221\220\007\025\001\220\201\ \013\007\216\001\025\203 \n\220\006)-10(\026\020)]TJ 33.357 1 Td [(A ne)11(w meth)11(od for w)11(ound defect closur)31(e af)-31(ter pilonidal sinus e)21(x)21.1(cision)]TJ ET 0 0 0 1 K 1 j 1 J [0 2.997]0 d /GS1 gs q 1 0 0 1 46.0167 331.1411 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 43.0197 331.1411 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q [0 2.997]0 d q 1 0 0 1 46.0167 303.5333 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 43.0197 303.5333 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q BT 0 0 0 1 k /T1_1 1 Tf 10 0 0 10 42.5197 724.8299 Tm (https://doi.org/10.33878/2073-7556-2024-23-1-129-135)Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 0.023 Tw 19 0 0 19 76.6798 695.3259 Tm [(\213\025\r\020\203 \006\221\025\006\025\f \221\007\013\006)-10(\026\220\017\016\006\n)10.1(\025\202)9.9(\025 \222\013\n\002\020\026\220\205 \002\013\001\016\r\025\202)10(\025 )]TJ 0.233 -1.105 Td [(\201\016\225\016\n)-10(\026)11(\013 \221\025\006)-9.9(\007\016 \220\006\006\016\017\016\001\220\205 \221\220\007\025\001\220\201\ \013\007\216\001\025\203 \n\220\006)-10(\026\020)]TJ 0 0 0 1 k /GS1 gs 0 Tw 14 0 0 14 42.5197 649.822 Tm [(\206\215\f\002\025\r\022)-23.2(\235.\213.)]TJ -0.069 Tc 0.069 Tw 8.162 0 0 8.162 119.299 654.484 Tm [(1,)-69(2)]TJ 0 Tc 0.023 Tw 14 0 0 14 130.6196 649.822 Tm [(, \214\013\002\020\016\r\022)-23.2(\b)-31(.\031)72(.)]TJ -0.069 Tc 0.069 Tw 8.162 0 0 8.162 216.9646 654.484 Tm [(1,)-69(2)]TJ 0 Tc 0.023 Tw 14 0 0 14 228.2852 649.822 Tm [(, \032)30(\002\220\013\001\201\013\225\220\007\025\r\022)-23.2(\037.\004.)]TJ 0 Tw 8.162 0 0 8.162 347.9639 654.484 Tm (1)Tj 5.83 0 0 5.83 42.5197 635.4827 Tm (1)Tj 0.023 Tw 10 0 0 10 45.8311 632.1527 Tm [(\031\214)42(\240)31(\211 \253\213\013\215\017\001\025-\220\006\006)-9.9(\007\016\201\025\r\013\026)11(\016\007\216\006\n\220\203 \220\001\006)-10(\026\220\026)-19.9(\215)-20(\026\022)-23.3(\236 \037)20(\002\013\016\r\013\205 \n)-9.9(\007\220\001\220\017\016\006\n\013\205 \f\025\007\216\001\220\227\013 \023\ 1 \220\024\016\001\220 \221\002\025\225\016\006\006\025\002\013 )]TJ -0.331 -1.2 Td [(\021.\004.\022)-23.3(\036\017\013\221\025\r\006\n)10.1(\025\202)10(\025\273 \005\220\001\220\006)-10(\026)11.1(\016\002\006)-10(\026\r\013 \222\201\002\013\r\025\025\207\002\013\001\016\001\220\205 \037\ )20(\002\013\006\001\025\201\013\002\006\n)10(\025\202)10(\025 \n\002\013\205 \(\215\007.\022)-23.3(1 \005\013\205, \201.\022)-23.2(1)112(6)58(7)127(, \202)62(.\022)-23.3(\037)20(\002\013\006\001\025\201\013\002)-31.9(, )]TJ 0 -1.2 TD (350086, \033\025\006\006\220\205\))Tj 0 Tw ( )Tj 5.83 0 0 5.83 42.5197 599.4828 Tm (2)Tj 0.023 Tw 10 0 0 10 45.8311 596.1528 Tm [(\210\031\214)21(\036)20(\240 \004\036 \253\037)62(\215\f\013\001\006\n\220\203 \202)10(\025\006\215\201\013\002\006)-9.9(\026\r\016\001\001\020\203 \024\016\201\220\227\220\001\006\n\220\203 \215\ \001\220\r\016\002\006\220\026)11(\016\026\273 \005\220\001\222\201\002\013\r\013 \033\025\006\006\220\220\ )]TJ -0.331 -1.2 Td [(\(\215\007.\022)-23.3(\220\024.\022)-23.2(\005\220\026\002\025\225\013\001\013 \021\016\201\220\001\013, \201.\022\ )-23.3(4, \202)62(.\022)-23.2(\037)19.9(\002\013\006\001\025\201\013\002)-31.9(, 350063, \033\025\006\006\220\205\))]TJ /T1_1 1 Tf -0.024 Tw 9 0 0 9 90.7087 565.6489 Tm (\037\036\035\034 \215\207\207\035\036\200\255\216\201\217\215\243: \205\023\ \205\006\001\031\021\025\031 \032\031\016\205\023\022\024\026\024\n\027 \ \004\025\032\205\032\202\025\006\031\t\013\n\202\n \023\031\006\031\021\025\ \002 \033\026\203\025\031\021\024\n\027 \t)Tj /Span<>> BDC ( )Tj EMC (\033\025\023\n\021\025\030\026\023\022\021\n\017 \013\025\t\024\n\017.)Tj 0.141 Tw 0 -1.111 TD (\201\037\215\036\217\220\235 \215)Tj /Span<>> BDC ( )Tj EMC (\240\036\220\255\200\235: \025\t\t\023\031\030\n\027\026\021\025\031 \002\ \027\023\002\023\n\t\022 \r\013\t\033\031\032\025\003\031\021\024\026\023\ \022\021\020\003 \032\026\021\030\n\003\025\016\025\032\n\027\026\021\021\ \020\003; \033\032\n\027\031\030\031\021\n \t\032\031\030\025 )Tj 0.054 Tw T* (100 \033\026\203\025\031\021\024\n\027 \t)Tj /Span<>> BDC ( )Tj EMC (\222 \027)Tj /Span<>> BDC ( )Tj EMC (\004\032\n\021\025\006\031\t\013\n\017 \t\024\026\030\025\025 \021\026)Tj /Span<>> BDC ( )Tj EMC (\005\026\016\031 \210\213\214\221 \217\215\215-\222\222\213 \2461, \n\024\ \030\031\023\031\021\025\031 \202\021\n\017\021\n\017 \004\025\032\205\032\ \202\025\025 \t)Tj /Span<>> BDC ( )Tj EMC (\002\021\027\026)Tj 0 Tw (-)Tj 0.124 Tw T* (\032\002 2021 \033\n)Tj /Span<>> BDC ( )Tj EMC (\002\021\027\026\032\022 2023 \202\202. \216)Tj /Span<>> BDC ( )Tj EMC (\n\t\021\n\027\021\n\017 \202\032\205\033\033\031 \027\020\033\n\023\021\ \002\023\n\t\022 \025\t\t\031\006\031\021\025\031 \033\025\023\n\021\025\ \030\026\023\022\021\n\017 \013\025\t\024\020 \t)Tj /Span<>> BDC ( )Tj EMC (\033\023\026\t\024\025\006\031)Tj 0 Tw (-)Tj 0.134 Tw T* (\t\013\025\003 \016\026\013\032\020\024\025\031\003 \032\026\021\031\027\ \n\202\n \030\031\f\031\013\024\026 \013\032\031\t\024\203\n\027\n-\013\n\ \033\006\025\013\n\027\n\017 \n\005\023\026\t\024\025, \t\n\202\023\026\t\ \021\n \033\026\024\031\021\024\205 RU \2462751821 \n\024 )Tj 0.1 Tw 0 -1.111 TD (19.07.21)Tj /Span<>> BDC ( )Tj EMC (\202. \201)Tj /Span<>> BDC ( )Tj EMC [(\027 \013\n\021\024\032\n\023\022\021\n\017 )0.5(\202\032\205\033\033\031 \027\020\033\n\023\021\002\023\n\t\022 )0.5(\025\t\t\031\006\031\021\025\031 )0.5(\222 \t)]TJ /Span<>> BDC ( )Tj EMC (\205\001\025\027\026\021\025\031\003 \033\n)Tj /Span<>> BDC ( )Tj EMC (\n\005\211\031\033\032\025\016\021\026\021\021\n\003\205 \t\033\n\t\n\005\ \205 )Tj 0.02 Tw 0 -1.111 TD (\033\n)Tj /Span<>> BDC ( )Tj EMC 1.233 0 Td [(Bascom )0.6(II )0.5(\(cleft )0.5(lift\). )0.6(\207\024\026\024\025\t\024\025\006\031\t\013\025 )0.6(\016\021\026\006\025\003\020\004 )0.6(\032\026\016\023\025\006\025\017 )0.6(\027)]TJ /Span<>> BDC ( )Tj EMC 24.677 0 Td [(\027\n\016\032\026\t\024\031 )0.5(\(\032)]TJ /Span<>> BDC ( )Tj EMC 5.28 0 Td (=)Tj /Span<>> BDC ( )Tj EMC 0.752 0 Td [(0,355\), )0.5(\215\240\220 )0.5(\(\032)]TJ /Span<>> BDC ( )Tj EMC 6.185 0 Td (=)Tj /Span<>> BDC ( )Tj EMC 0.752 0 Td [(0,467\), )0.5(\032\026\t\033\032\031)]TJ 0 Tw (-)Tj -0.011 Tw -38.881 -1.111 Td (\030\031\023\031\021\025\025 \033\n)Tj /Span<>> BDC ( )Tj EMC (\033\n\023\205 \(\032)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (1,0\) \025)Tj /Span<>> BDC ( )Tj EMC (\006\026\t\024\n\024\031 \032\031\203\025\030\025\027\n\027 \(\032)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,204\) \027)Tj /Span<>> BDC ( )Tj EMC (\t\032\026\027\021\025\027\026\031\003\020\004 \202\032\205\033\033\026\004\ \021\031 \005\020\023\n. \216\032\031\003\002 \n\033\031\032\026\203\025\ \025 )Tj 0.06 Tw T* (\027)Tj /Span<>> BDC ( )Tj EMC [(\n\t\021\n\027\021\n\017 )0.5(\202\032\205\033\033\031 \005\020\023\n \005\n\023\022\001\031 )0.5(\(\032)]TJ /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC [(0,001\), \006\024\n \t\027\002\016\026\021\n )0.5(\t)]TJ /Span<>> BDC ( )Tj EMC (\005\n\023\031\031 \024\032\205\030\n\031\003\013\n\017 \003\031\024\n\030\ \025\013\n\017 \n\033\031\032\026\203\025\025. \222\n\017\013\n-)Tj 0.009 Tw T* (\030\031\021\022 \(\032)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,027\), \006\026\t\024\n\024\026 \n\t\023\n\204\021\031\021\025\017 \(\032\ )Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,028\) \027)Tj /Span<>> BDC ( )Tj EMC (\n\t\021\n\027\021\n\017 \202\032\205\033\033\031 \t\024\026\024\025\t\024\ \025\006\031\t\013\025 \016\021\026\006\025\003\n \005\020\023\026 \003\031\ \021\022\001\031. )Tj 0.276 Tw T* (\212\036\221\214\035\034\220\201\220\235: \021\031\t\003\n\024\032\002 \021\ \026)Tj /Span<>> BDC ( )Tj EMC (\032\026\016\032\026\005\n\024\026\021\021\020\031 \t\n\027\032\031\003\031\ \021\021\020\031 \t\033\n\t\n\005\020 \004\025\032\205\032\202\025\006\031\ \t\013\n\202\n \023\031\006\031\021\025\002 \222, \006\026\t\024\n\024\026\ )Tj -0.015 Tw T* (\n\t\023\n\204\021\031\021\025\017 \n\t\024\026\031\024\t\002 \027\020\t\ \n\013\n\017, \004\n\024\002 \006\026\t\024\n\024\205 \032\031\203\025\030\ \025\027\n\027 \205\030\026\023\n\t\022 \t\021\025\016\025\024\022 \033\n\ )Tj /Span<>> BDC ( )Tj EMC (\t\032\026\027\021\031\021\025\007 \t)Tj /Span<>> BDC ( )Tj EMC (\032\026\021\031\031 \033\032\025\021\002\024\020\003\025 )Tj 0.107 Tw T* (\003\031\024\n\030\026\003\025 \023\031\006\031\021\025\002. \032\025)Tj /Span<>> BDC ( )Tj EMC (\033\032\025\003\031\021\031\021\025\025 \032\026\016\032\026\005\n\024\026\ \021\021\n\202\n \025)Tj /Span<>> BDC ( )Tj EMC (\016\026\033\026\024\031\021\024\n\027\026\021\021\n\202\n \021\026\003\025\ \t\033\n\t\n\005\026 \205\030\026\023\n\t\022 \t\021\025\016\025\024\022\ )Tj 0.09 Tw T* [(\006\026\t\024\n\024\205 )0.6(\n\t\023\n\204\021\031\021\025\017 )0.6(\030\n)]TJ /Span<>> BDC ( )Tj EMC 10.567 0 Td [(4%, )0.6(\026)]TJ /Span<>> BDC ( )Tj EMC 2.589 0 Td [(\006\026\t\024\n\024\205 )0.6(\032\031\203\025\030\025\027\n\027)]TJ /Span<>> BDC ( )Tj EMC 8.669 0 Td [(\227 )0.5(\030\n)]TJ /Span<>> BDC ( )Tj EMC 2.623 0 Td [(2%, )0.6(\205\030\026\023\n\t\022 )0.5(\025\016\005\031\204\026\024\022 )0.5(\033\n\027\024\n\032\021\020\004 )0.5(\004\025\032\205\032\202\025\006\031\t\013\025\004 )]TJ 0.023 Tw -24.448 -1.111 Td (\027\003\031\001\026\024\031\023\022\t\024\027 \025)Tj /Span<>> BDC ( )Tj EMC (\030\n\005\025\024\022\t\002 \032\026\021\021\031\202\n \027\n\t\t\024\026\ \021\n\027\023\031\021\025\002 \024\032\205\030\n\027\n\017 \026\013\024\ \025\027\021\n\t\024\025.)Tj -0.008 Tw T* (\221\201\222\035\223\224\036\217\215\036: \032\026\016\032\026\005\n\024\ \026\021\021\020\017 \021\026\003\025 \t\033\n\t\n\005 \016\026\013\032\020\ \024\025\002 \032\026\021\031\027\n\202\n \030\031\f\031\013\024\026 \033\ \n\t\023\031 \025\t\t\031\006\031\021\025\002 \222 \033\032\n\t\024 \027\ )Tj /Span<>> BDC ( )Tj EMC (\024\031\004\021\025)Tj 0 Tw (-)Tj -0.034 Tw T* (\006\031\t\013\n\003 \025\t\033\n\023\021\031\021\025\025 \025)Tj /Span<>> BDC ( )Tj EMC (\021\026\030\245\204\031\021, \006\024\n \033\n\016\027\n\023\002\031\024\ \033\032\031\030\023\n\204\025\024\022 \031\202\n \027)Tj /Span<>> BDC ( )Tj EMC (\032\205\024\025\021\021\n\017 \033\032\026\013\024\025\013\031 \004\025\ \032\205\032\202\025\006\031\t\013\n\202\n \023\031\006\031\021\025\002 \ )Tj 0 Tw T* (\222.)Tj /T1_2 1 Tf 0.01 Tc 0.004 Tw 8 0 0 8 42.5596 380.3796 Tm [(\037\036\035\034\033\032\031\033)5( \030\036\027\032\026:)]TJ /T1_1 1 Tf 0 Tc 0.009 Tw 8.479 0 Td ( \r\033\025\024\031\023\025\026\023\022\021\020\017 \013\n\033\006\025\013\ \n\027\020\017 \004\n\030, \t\033\n\t\n\005\020 \205\001\025\027\026\021\ \025\002 \032\026\021\020, \033\025\023\n\021\025\030\026\023\022\021\026\ \002 \013\025\t\024\026, \033\023\026\t\024\025\013\026 \032\026\021\020\ \003\031\t\024\021\020\003\025 \024\013\026\021\002)Tj 0 Tw (-)Tj 0.023 Tw -8.484 -1.2 Td (\003\025, \013\025\t\024\026 \013\032\031\t\024\203\n\027\n\017 \n\005\023\ \026\t\024\025)Tj /T1_2 1 Tf 0.01 Tc 0.018 Tw 0.005 -1.909 Td [(\037\027\025\024\036\023\037\022)5( \023\025\022\033\021\033\030\027\032:)]TJ /T1_1 1 Tf 0 Tc 0.023 Tw 10.401 0 Td ( \026\027\024\n\032\020 \016\026\002\027\023\002\007\024 \n\005 \n\024\t\ \205\024\t\024\027\025\025 \013\n\021\f\023\025\013\024\026 \025\021\024\ \031\032\031\t\n\027)Tj /T1_2 1 Tf 0.01 Tc -0.01 Tw -10.401 -1.909 Td (\024\023\025\026\025\030\023\021\027\032\026\025\023\033:)Tj /T1_1 1 Tf 0 Tc 0.023 Tw 8.655 0 Td ( \025\t\t\023\031\030\n\027\026\021\025\031 \021\031 \025\003\031\023\n \ \t\033\n\021\t\n\032\t\013\n\017 \033\n\030\030\031\032\204\013\025)Tj /T1_2 1 Tf 0.027 Tc -0.04 Tw -8.655 -2.617 Td [(\020\036\017)5.1( \016\023\022\023\021\027\032\026\025\023\017:)]TJ /T1_3 1 Tf 0.017 Tc -0.035 Tw 9.03 0 Td ( \234\031\002\030\024\r)Tj /Span<>> BDC ( )Tj EMC (\224.\203., \207\026\030\t\001\036\r)Tj /Span<>> BDC ( )Tj EMC (\202.\206., \230\030\017\026\027\007\026\235\017\035\024\r)Tj /Span<>> BDC ( )Tj EMC [(\025.\200. \203\024\r\t\005 \f\023\024\f\024\002 \023\035\026\f\021\017\004\ \036\f\022\024\020\024 \026\022\030\t\021\017\016 \030\026\027\036\r\024\ \020\024 \007\036\235\036\022\021\026 \023\024\f\035\036)17( )]TJ -0.003 Tc -0.041 Tw -9.035 -1.2 Td (\017\f\f\036\004\036\027\017\016 \023\017\035\024\027\017\007\026\035\034\ \027\024\005 \022\017\f\021\t. )Tj /T1_1 1 Tf 0.003 Tw (\222\n\023\n\033\032\n\013\024\n\023\n\202\025\002.)Tj /T1_3 1 Tf -0.041 Tw ( 2024; \021.)Tj /Span<>> BDC ( )Tj EMC (23, \225)Tj /Span<>> BDC ( )Tj EMC (1, \f.)Tj /Span<>> BDC ( )Tj EMC (129\226135. https://doi.org/10.33878/2073-7556-2024-23-1-129-135)Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 0 Tc 0.023 Tw 18 0 0 18 126.5735 277.364 Tm [(A ne)11(w meth)11.1(od for w)11(ound defect closur)31(e )]TJ 2.311 -1.167 Td [(af)-31(ter pilonidal sinus e)21(x)21(cision)]TJ 0 0 0 1 k /GS1 gs 0 Tw 14 0 0 14 42.5197 231.86 Tm [(Erik\022)-23.2(N.\022)-23.3(Sh)11(ubr)20(ov)]TJ -0.069 Tc 0.069 Tw 8.162 0 0 8.162 130.7407 236.522 Tm [(1,)-69(2)]TJ 0 Tc 0.023 Tw 14 0 0 14 142.0613 231.86 Tm [(, Ale)21(x)11(ander\022)-23.2(G.\022)-23.3(Bar)-30.9(y)9.9(sh)11.1(e)10.9(v)]TJ -0.069 Tc 0.069 Tw 8.162 0 0 8.162 280.8956 236.522 Tm [(1,)-69(2)]TJ 0 Tc 0.023 Tw 14 0 0 14 292.2162 231.86 Tm [(, K)41(onstantin\022)-23.2(V)62(.\022)-23.3(T)20(riandaf)-20.9(ilov)]TJ 0 Tw 8.162 0 0 8.162 442.7816 236.522 Tm (1)Tj 5.83 0 0 5.83 42.5197 217.5208 Tm (1)Tj 0.023 Tw 10 0 0 10 45.8311 214.1908 Tm [(Ochapov)10(sky Regional Clinical Hospital No. 1 Kr)21(asnodar \(1 May)21(a\022)-23.2(st., 1)112(6)58(7)127(, Kr)21(asnodar)52.1(, 350086, Russia\))]TJ 0 Tw ( )Tj 5.83 0 0 5.83 42.5197 205.5208 Tm (2)Tj 0.023 Tw 10 0 0 10 45.8311 202.1908 Tm [(K)31(uban State Medical Univ)12.1(er)20(sit)-20(y \(Mitr)20.1(ofan\013 Sedina\022)-23.2(st., 4, Kr)21.1(asnodar)52(, 350063, Russia\))]TJ /T1_1 1 Tf 9 0 0 9 90.7087 183.6869 Tm [(AIM: to ev)16(aluate the ef)-40(f)-43(icacy of or)-37(iginal method for pilonid)26(al sinus \(PS\) treatment.)]TJ 0.17 Tw T* [(P)45(A)45(TIENT)-9.9(S A)53(ND METHODS: a randomized study included 100 patients with PS in the chro\ nic stag)12(e at the S)28(tate )]TJ 0.005 Tw T* [(Budg)12(etar)-42.9(y Healthcare Institution R)21(esearch Institute-KKB N)17(o. 1, Depar)-39.9(tment of Purulent Surg)12(er)-42.9(y from Januar)-42.9(y 2021 )]TJ 0.002 Tw T* [(to Januar)-42.9(y 2023. In the main g)14(roup, e)-15(xcision of the pilonid)26.1(al sinus w)13(as per)-34(for)-14(med with plastic closure of the w)12(ound )]TJ -0.011 Tw T* [(defect )0.6(of )0.5(the )0.5(sacrococcyg)12.1(eal )0.5(region )0.5(according )0.6(to )0.5(R)27(U )0.5(patent )0.6(N)17(o. )0.5(2751821 )0.5(from )0.5(07/19/21. )0.5(The )0.5(control )0.5(g)14(roup )0.5(included )]TJ 0.113 Tw 0 -1.111 TD [(patients with Bascom II \(clef)-45.9(t lif)-46(t\). There w)12(ere no signif)-43(icant dif)-40(ferences in ag)12(e \(p)]TJ /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0.355\), BMI \(p)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0.467\), )Tj 0.023 Tw 0 -1.111 TD [(g)12(ender distr)-36.9(ibution \(p)]TJ /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC [(1.0\), recur)-15.9(rence rate \(p)]TJ /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,204\).)Tj -0.034 Tw T* [(RESUL)30(T)-10(S: the operation time in the main g)14(roup w)13(as long)12(er \(p)]TJ /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC [(0.001\), which is associated with a surgical techniq)14(ue. )]TJ 0.069 Tw T* [(P)15(ost-op stay \(p)]TJ /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0.027\), the morbidity \(p)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC [(0,028\) in the main g)14(roup w)13(as signif)-43(icantly low)12(er)51(. The com)16(plications )]TJ 0.023 Tw T* [(rate reduced to 4%, and the recur)-15.9(rence rate to 2%. It w)13(as possible to av)13(oid re-operations.)]TJ T* [(C)21(ON)22(CLUSION: the or)-37(iginal method for w)12(ound closure af)-46(ter PS e)-15(xcision is sim)16(ple and reliable.)]TJ ET 1 0.68 0 0.12 k /GS0 gs q 1 0 0 1 42.5197 574.1533 cm 0 0 m 0 0 l 0 -11.339 l 42.52 -11.339 l 42.52 0 l h f Q BT 0 0 0 0 k /T1_2 1 Tf 0 Tw 9 0 0 9 47.6607 565.226 Tm (\021\033\r\035\f\033)Tj ET 1 0.68 0 0.12 k q 1 0 0 1 42.5197 192.1914 cm 0 0 m 0 0 l 0 -11.339 l 42.52 -11.339 l 42.52 0 l h f Q BT 0 0 0 0 k /T1_2 1 Tf 9 0 0 9 45.2263 183.2641 Tm (ABSTRACT)Tj 1 0.68 0 0.12 k /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\033\030\031\030\213\b)-20.9(\035\231\213\233\t \021\032)50(\b)42(\032\231\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj /T1_4 1 Tf 25 0 0 25 505.5021 56.0378 Tm (129)Tj ET q 0 g 0 G 0 j 0 J /Fm1 Do Q 0 0 0 0 k 368.504 725.67 59.155 11.338 re f /PlacedPDF /MC0 BDC q 369.135 736.808 m 368.896 736.808 368.703 736.616 368.703 736.376 c 368.703 736.376 l 368.703 726.285 l 368.703 726.045 368.896 725.853 369.135 725.853 c 369.135 725.853 l 427.035 725.853 l 427.273 725.853 427.469 726.045 427.469 726.285 c 427.469 726.285 l 427.469 736.376 l 427.469 736.616 427.273 736.808 427.035 736.808 c 427.035 736.808 l h W n q 0 g -0.0000005 -10.9560913 -10.9560913 0.0000005 398.0855785 736.8086309 cm BX /Sh0 sh EX Q Q q 368.504 725.67 59.155 11.337 re W n 0 0 0 0.84 k q 1 0 0 1 385.2169 732.4249 cm 0 0 m -0.025 0.1 -0.063 0.196 -0.112 0.287 c -0.157 0.374 -0.218 0.451 -0.292 0.515 c -0.37 0.582 -0.46 0.632 -0.558 0.664 c -0.669 0.701 -0.786 0.719 -0.903 0.717 c -1.076 0.722 -1.247 0.681 -1.4 0.6 c -1.536 0.526 -1.652 0.42 -1.74 0.292 c -1.83 0.158 -1.895 0.008 -1.934 -0.149 c -2.018 -0.48 -2.018 -0.827 -1.934 -1.158 c -1.896 -1.316 -1.83 -1.466 -1.74 -1.602 c -1.653 -1.731 -1.536 -1.837 -1.4 -1.912 c -1.247 -1.993 -1.076 -2.033 -0.903 -2.029 c -0.774 -2.032 -0.647 -2.006 -0.528 -1.955 c -0.427 -1.906 -0.337 -1.837 -0.263 -1.753 c -0.185 -1.665 -0.124 -1.563 -0.082 -1.453 c -0.034 -1.338 0 -1.218 0.019 -1.094 c 0.635 -1.094 l 0.624 -1.297 0.578 -1.497 0.497 -1.684 c 0.421 -1.857 0.312 -2.015 0.175 -2.146 c 0.039 -2.277 -0.123 -2.379 -0.3 -2.446 c -0.492 -2.519 -0.695 -2.555 -0.9 -2.552 c -1.15 -2.557 -1.397 -2.506 -1.625 -2.404 c -1.829 -2.307 -2.01 -2.169 -2.157 -1.997 c -2.308 -1.821 -2.423 -1.617 -2.497 -1.397 c -2.655 -0.924 -2.655 -0.412 -2.497 0.061 c -2.423 0.281 -2.307 0.485 -2.157 0.661 c -2.01 0.833 -1.829 0.973 -1.625 1.07 c -1.398 1.174 -1.15 1.226 -0.9 1.222 c -0.707 1.223 -0.515 1.196 -0.329 1.14 c -0.159 1.088 0.001 1.006 0.144 0.898 c 0.278 0.793 0.39 0.662 0.473 0.513 c 0.562 0.349 0.615 0.167 0.629 -0.019 c 0 -0.019 l 0 0 l f Q q 1 0 0 1 386.3458 733.5723 cm 0 0 m 0.584 0 l 0.584 -1.328 l 0.662 -1.204 0.771 -1.103 0.9 -1.033 c 1.046 -0.951 1.213 -0.91 1.381 -0.914 c 1.627 -0.9 1.869 -0.979 2.058 -1.137 c 2.234 -1.312 2.325 -1.556 2.305 -1.803 c 2.305 -3.596 l 1.716 -3.596 l 1.716 -1.976 l 1.724 -1.817 1.678 -1.66 1.585 -1.53 c 1.486 -1.43 1.347 -1.379 1.206 -1.392 c 1.114 -1.39 1.024 -1.408 0.94 -1.445 c 0.865 -1.479 0.798 -1.529 0.744 -1.591 c 0.687 -1.656 0.645 -1.73 0.616 -1.812 c 0.586 -1.896 0.571 -1.986 0.571 -2.077 c 0.571 -3.615 l 0 -3.615 l 0 0 l f Q q 1 0 0 1 389.692 731.1235 cm 0 0 m 0 -0.099 0.014 -0.198 0.043 -0.292 c 0.069 -0.382 0.112 -0.466 0.17 -0.54 c 0.229 -0.611 0.304 -0.669 0.388 -0.709 c 0.486 -0.754 0.594 -0.776 0.702 -0.773 c 0.845 -0.78 0.987 -0.742 1.108 -0.664 c 1.217 -0.582 1.296 -0.468 1.336 -0.337 c 1.881 -0.337 l 1.827 -0.603 1.675 -0.838 1.456 -0.996 c 1.35 -1.073 1.231 -1.131 1.105 -1.169 c 0.971 -1.208 0.831 -1.229 0.691 -1.227 c 0.509 -1.227 0.328 -1.191 0.16 -1.121 c 0.007 -1.063 -0.13 -0.972 -0.244 -0.855 c -0.356 -0.73 -0.44 -0.583 -0.491 -0.422 c -0.548 -0.243 -0.576 -0.056 -0.574 0.133 c -0.575 0.313 -0.545 0.493 -0.486 0.664 c -0.426 0.826 -0.335 0.974 -0.22 1.102 c 0.004 1.375 0.338 1.534 0.691 1.535 c 0.883 1.539 1.072 1.495 1.243 1.408 c 1.402 1.326 1.541 1.209 1.649 1.067 c 1.759 0.922 1.838 0.757 1.883 0.582 c 1.932 0.396 1.945 0.203 1.92 0.013 c 0 0.013 l 0 0 l 1.342 0.377 m 1.335 0.468 1.315 0.557 1.283 0.643 c 1.253 0.724 1.209 0.798 1.153 0.863 c 1.097 0.922 1.03 0.97 0.957 1.004 c 0.874 1.043 0.783 1.063 0.691 1.062 c 0.6 1.062 0.509 1.044 0.425 1.009 c 0.345 0.976 0.273 0.926 0.213 0.863 c 0.153 0.799 0.105 0.724 0.072 0.643 c 0.037 0.559 0.017 0.468 0.014 0.377 c 1.355 0.377 l h f Q q 1 0 0 1 393.8116 731.7051 cm 0 0 m -0.012 0.144 -0.082 0.276 -0.194 0.366 c -0.31 0.452 -0.451 0.495 -0.595 0.489 c -0.675 0.488 -0.755 0.476 -0.831 0.452 c -0.918 0.424 -0.998 0.375 -1.062 0.311 c -1.142 0.229 -1.202 0.131 -1.24 0.024 c -1.29 -0.132 -1.312 -0.296 -1.304 -0.459 c -1.304 -0.569 -1.292 -0.677 -1.267 -0.784 c -1.244 -0.885 -1.202 -0.983 -1.145 -1.07 c -1.09 -1.154 -1.016 -1.224 -0.93 -1.275 c -0.833 -1.33 -0.722 -1.356 -0.611 -1.352 c -0.457 -1.357 -0.307 -1.301 -0.194 -1.195 c -0.078 -1.077 -0.005 -0.922 0.011 -0.757 c 0.587 -0.757 l 0.556 -1.055 0.419 -1.332 0.202 -1.538 c -0.022 -1.721 -0.306 -1.815 -0.595 -1.803 c -0.777 -1.806 -0.958 -1.771 -1.126 -1.7 c -1.293 -1.642 -1.445 -1.547 -1.57 -1.421 c -1.68 -1.297 -1.763 -1.151 -1.814 -0.993 c -1.87 -0.822 -1.898 -0.643 -1.896 -0.462 c -1.898 -0.276 -1.871 -0.091 -1.817 0.087 c -1.766 0.252 -1.682 0.405 -1.57 0.537 c -1.459 0.664 -1.323 0.766 -1.168 0.834 c -0.991 0.914 -0.798 0.955 -0.603 0.954 c -0.457 0.954 -0.311 0.935 -0.17 0.895 c -0.039 0.858 0.084 0.799 0.194 0.72 c 0.302 0.643 0.393 0.543 0.459 0.428 c 0.531 0.298 0.572 0.155 0.582 0.008 c 0 0.008 l 0 0 l f Q q 1 0 0 1 394.8712 733.5723 cm 0 0 m 0.577 0 l 0.577 -2.048 l 1.615 -0.985 l 2.322 -0.985 l 1.323 -1.944 l 2.417 -3.604 l 1.716 -3.604 l 0.919 -2.337 l 0.577 -2.669 l 0.577 -3.604 l 0 -3.604 l h f Q q 1 0 0 1 398.712 732.5762 cm 0 0 m 0.436 0 l 0.436 0.218 l 0.429 0.352 0.448 0.486 0.488 0.614 c 0.521 0.705 0.577 0.786 0.651 0.85 c 0.717 0.905 0.795 0.943 0.879 0.961 c 0.966 0.979 1.056 0.988 1.145 0.988 c 1.28 0.993 1.416 0.981 1.548 0.954 c 1.548 0.505 l 1.509 0.516 1.469 0.523 1.429 0.528 c 1.379 0.532 1.33 0.532 1.28 0.528 c 1.209 0.53 1.14 0.511 1.081 0.473 c 1.019 0.419 0.987 0.337 0.999 0.255 c 0.999 -0.011 l 1.498 -0.011 l 1.498 -0.441 l 1.009 -0.441 l 1.009 -2.622 l 0.436 -2.622 l 0.436 -0.428 l 0.005 -0.428 l 0.005 0 l 0 0 l f Q q 1 0 0 1 401.7535 729.8965 cm 0 0 m -0.191 -0.003 -0.381 0.032 -0.559 0.104 c -0.715 0.167 -0.856 0.264 -0.972 0.388 c -1.091 0.512 -1.181 0.659 -1.238 0.82 c -1.356 1.18 -1.356 1.567 -1.238 1.925 c -1.181 2.087 -1.091 2.234 -0.972 2.358 c -0.856 2.481 -0.715 2.578 -0.559 2.643 c -0.199 2.78 0.198 2.78 0.558 2.643 c 0.714 2.578 0.855 2.481 0.972 2.358 c 1.09 2.234 1.181 2.087 1.237 1.925 c 1.355 1.567 1.355 1.18 1.237 0.82 c 1.181 0.659 1.09 0.512 0.972 0.388 c 0.855 0.266 0.713 0.169 0.558 0.106 c 0.38 0.034 0.191 -0.002 0 0 c 0 0.454 m 0.115 0.451 0.23 0.479 0.332 0.534 c 0.424 0.586 0.502 0.659 0.562 0.746 c 0.624 0.836 0.669 0.936 0.695 1.041 c 0.752 1.26 0.752 1.491 0.695 1.71 c 0.669 1.816 0.625 1.916 0.562 2.005 c 0.502 2.091 0.423 2.163 0.332 2.215 c 0.123 2.323 -0.126 2.323 -0.335 2.215 c -0.427 2.163 -0.505 2.091 -0.566 2.005 c -0.628 1.916 -0.673 1.816 -0.699 1.71 c -0.756 1.491 -0.756 1.26 -0.699 1.041 c -0.672 0.936 -0.627 0.836 -0.566 0.746 c -0.506 0.659 -0.427 0.586 -0.335 0.534 c -0.232 0.478 -0.117 0.451 0 0.454 c f Q q 1 0 0 1 403.5515 732.5762 cm 0 0 m 0.531 0 l 0.531 -0.505 l 0.55 -0.43 0.583 -0.359 0.629 -0.297 c 0.681 -0.229 0.74 -0.167 0.807 -0.114 c 0.877 -0.059 0.956 -0.014 1.039 0.019 c 1.123 0.053 1.213 0.07 1.304 0.069 c 1.52 0.069 l 1.52 -0.486 l 1.395 -0.467 l 1.269 -0.467 l 1.178 -0.468 1.087 -0.488 1.004 -0.526 c 0.917 -0.565 0.839 -0.625 0.778 -0.699 c 0.716 -0.783 0.669 -0.878 0.643 -0.98 c 0.604 -1.104 0.584 -1.233 0.586 -1.362 c 0.586 -2.603 l 0.01 -2.603 l 0.01 0 l 0 0 l f Q q 1 0 0 1 409.0202 729.9683 cm 0 0 m -0.577 0 l -0.577 0.364 l -0.649 0.23 -0.759 0.121 -0.893 0.047 c -1.022 -0.029 -1.169 -0.07 -1.32 -0.072 c -1.595 -0.095 -1.866 0.002 -2.064 0.194 c -2.234 0.413 -2.316 0.687 -2.295 0.964 c -2.295 2.608 l -1.719 2.608 l -1.719 1.014 l -1.735 0.843 -1.689 0.67 -1.588 0.531 c -1.492 0.433 -1.357 0.382 -1.219 0.39 c -1.116 0.387 -1.012 0.406 -0.917 0.446 c -0.84 0.479 -0.772 0.531 -0.72 0.595 c -0.667 0.661 -0.63 0.738 -0.611 0.82 c -0.588 0.911 -0.577 1.003 -0.577 1.097 c -0.577 2.611 l 0 2.611 l 0 0 l f Q q 1 0 0 1 409.6413 732.5762 cm 0 0 m 0.545 0 l 0.545 -0.353 l 0.617 -0.209 0.736 -0.094 0.882 -0.026 c 1.03 0.04 1.19 0.073 1.352 0.072 c 1.535 0.075 1.717 0.038 1.883 -0.037 c 2.031 -0.106 2.161 -0.208 2.263 -0.334 c 2.366 -0.465 2.442 -0.615 2.489 -0.775 c 2.54 -0.948 2.566 -1.127 2.566 -1.307 c 2.566 -1.479 2.542 -1.651 2.497 -1.817 c 2.455 -1.973 2.385 -2.121 2.29 -2.252 c 2.099 -2.522 1.789 -2.682 1.458 -2.68 c 1.369 -2.681 1.28 -2.674 1.193 -2.659 c 1.11 -2.644 1.028 -2.618 0.951 -2.584 c 0.875 -2.552 0.802 -2.509 0.736 -2.457 c 0.671 -2.406 0.615 -2.343 0.571 -2.273 c 0.571 -3.575 l -0.005 -3.575 l -0.005 0 l 0 0 l 2.008 -1.307 m 2.008 -1.191 1.993 -1.076 1.963 -0.964 c 1.936 -0.859 1.89 -0.759 1.828 -0.669 c 1.768 -0.584 1.69 -0.514 1.599 -0.462 c 1.503 -0.409 1.395 -0.382 1.286 -0.385 c 1.072 -0.372 0.867 -0.467 0.738 -0.638 c 0.607 -0.836 0.543 -1.072 0.555 -1.31 c 0.554 -1.433 0.57 -1.557 0.603 -1.676 c 0.631 -1.781 0.68 -1.879 0.747 -1.965 c 0.809 -2.044 0.886 -2.109 0.975 -2.157 c 1.071 -2.206 1.178 -2.23 1.286 -2.229 c 1.401 -2.232 1.517 -2.205 1.618 -2.148 c 1.708 -2.096 1.785 -2.025 1.843 -1.939 c 1.903 -1.85 1.945 -1.751 1.968 -1.646 c 1.995 -1.535 2.008 -1.421 2.008 -1.307 c f Q q 1 0 0 1 415.1662 729.9683 cm 0 0 m -0.545 0 l -0.545 0.353 l -0.616 0.211 -0.734 0.099 -0.879 0.034 c -1.027 -0.031 -1.187 -0.065 -1.349 -0.064 c -1.532 -0.067 -1.714 -0.03 -1.88 0.045 c -2.028 0.113 -2.158 0.214 -2.26 0.34 c -2.364 0.47 -2.441 0.62 -2.486 0.781 c -2.538 0.958 -2.564 1.143 -2.563 1.328 c -2.568 1.536 -2.536 1.742 -2.468 1.938 c -2.41 2.097 -2.319 2.242 -2.202 2.364 c -2.101 2.471 -1.977 2.555 -1.838 2.608 c -1.705 2.659 -1.563 2.685 -1.421 2.685 c -1.338 2.685 -1.256 2.678 -1.174 2.664 c -1.091 2.648 -1.01 2.624 -0.932 2.589 c -0.855 2.556 -0.783 2.514 -0.717 2.462 c -0.652 2.411 -0.597 2.349 -0.553 2.279 c -0.553 3.606 l 0.024 3.606 l 0.024 0 l 0 0 l -2.008 1.277 m -2.009 1.166 -1.994 1.056 -1.965 0.948 c -1.939 0.845 -1.896 0.748 -1.835 0.661 c -1.777 0.578 -1.699 0.508 -1.61 0.459 c -1.404 0.355 -1.162 0.355 -0.956 0.459 c -0.866 0.512 -0.789 0.585 -0.73 0.671 c -0.671 0.762 -0.626 0.862 -0.6 0.966 c -0.572 1.076 -0.558 1.188 -0.558 1.301 c -0.543 1.542 -0.612 1.781 -0.751 1.979 c -0.88 2.14 -1.078 2.229 -1.283 2.22 c -1.402 2.224 -1.52 2.196 -1.623 2.138 c -1.714 2.083 -1.793 2.009 -1.852 1.92 c -1.911 1.828 -1.954 1.725 -1.977 1.617 c -1.999 1.505 -2.01 1.392 -2.008 1.277 c f Q q 1 0 0 1 417.9787 730.5499 cm 0 0 m -0.004 -0.052 0.005 -0.104 0.026 -0.151 c 0.052 -0.185 0.094 -0.202 0.136 -0.197 c 0.197 -0.197 l 0.223 -0.2 0.25 -0.2 0.276 -0.197 c 0.276 -0.595 l 0.199 -0.619 l 0.101 -0.64 l 0 -0.656 l -0.085 -0.656 l -0.187 -0.66 -0.288 -0.635 -0.377 -0.584 c -0.461 -0.528 -0.516 -0.437 -0.528 -0.337 c -0.648 -0.451 -0.792 -0.534 -0.951 -0.579 c -1.106 -0.628 -1.269 -0.654 -1.432 -0.656 c -1.546 -0.657 -1.659 -0.641 -1.769 -0.608 c -1.872 -0.579 -1.967 -0.531 -2.053 -0.468 c -2.136 -0.405 -2.203 -0.324 -2.25 -0.231 c -2.3 -0.127 -2.326 -0.012 -2.324 0.104 c -2.33 0.24 -2.299 0.375 -2.236 0.497 c -2.181 0.594 -2.101 0.675 -2.005 0.733 c -1.905 0.791 -1.795 0.833 -1.681 0.855 c -1.562 0.88 -1.442 0.899 -1.32 0.914 c -1.222 0.933 -1.123 0.947 -1.022 0.956 c -0.938 0.963 -0.855 0.977 -0.773 0.999 c -0.708 1.014 -0.649 1.046 -0.6 1.092 c -0.556 1.144 -0.533 1.211 -0.536 1.28 c -0.534 1.344 -0.553 1.408 -0.59 1.46 c -0.624 1.507 -0.668 1.544 -0.72 1.569 c -0.775 1.596 -0.834 1.613 -0.895 1.62 c -0.955 1.624 -1.016 1.624 -1.076 1.62 c -1.215 1.625 -1.354 1.591 -1.474 1.519 c -1.581 1.45 -1.647 1.333 -1.652 1.206 c -2.231 1.206 l -2.227 1.354 -2.185 1.498 -2.108 1.625 c -2.041 1.733 -1.951 1.824 -1.843 1.891 c -1.729 1.96 -1.603 2.007 -1.472 2.032 c -1.329 2.072 -1.183 2.098 -1.036 2.109 c -0.908 2.109 -0.781 2.096 -0.656 2.069 c -0.538 2.044 -0.425 2 -0.321 1.939 c -0.225 1.88 -0.143 1.8 -0.083 1.705 c -0.02 1.599 0.012 1.478 0.008 1.354 c 0.008 0.013 l 0 0 l -0.576 0.728 m -0.674 0.667 -0.785 0.631 -0.9 0.624 c -1.028 0.612 -1.155 0.594 -1.283 0.571 c -1.343 0.561 -1.402 0.547 -1.46 0.528 c -1.515 0.511 -1.566 0.485 -1.612 0.451 c -1.657 0.419 -1.692 0.376 -1.716 0.327 c -1.742 0.267 -1.755 0.203 -1.753 0.138 c -1.755 0.079 -1.735 0.021 -1.697 -0.024 c -1.661 -0.067 -1.615 -0.103 -1.564 -0.127 c -1.509 -0.154 -1.451 -0.171 -1.392 -0.181 c -1.335 -0.19 -1.278 -0.196 -1.222 -0.197 c -1.152 -0.196 -1.083 -0.188 -1.015 -0.173 c -0.94 -0.156 -0.87 -0.127 -0.805 -0.088 c -0.74 -0.048 -0.684 0.004 -0.64 0.066 c -0.594 0.134 -0.571 0.215 -0.574 0.297 c -0.574 0.725 l h f Q q 1 0 0 1 418.3371 732.5762 cm 0 0 m 0.434 0 l 0.434 0.784 l 0.996 0.784 l 0.996 0 l 1.527 0 l 1.527 -0.43 l 0.996 -0.43 l 0.996 -1.822 l 0.993 -1.874 0.993 -1.927 0.996 -1.979 c 1 -2.018 1.011 -2.056 1.031 -2.09 c 1.05 -2.122 1.079 -2.146 1.113 -2.159 c 1.162 -2.177 1.213 -2.185 1.265 -2.183 c 1.387 -2.183 l 1.428 -2.181 1.469 -2.175 1.509 -2.165 c 1.509 -2.608 l 1.323 -2.629 l 1.261 -2.633 1.199 -2.633 1.137 -2.629 c 1.013 -2.633 0.89 -2.619 0.771 -2.587 c 0.688 -2.564 0.613 -2.52 0.553 -2.459 c 0.499 -2.4 0.462 -2.328 0.446 -2.25 c 0.427 -2.155 0.416 -2.059 0.415 -1.963 c 0.415 -0.428 l -0.019 -0.428 l -0.019 0 l 0 0 l f Q q 1 0 0 1 420.7277 731.1235 cm 0 0 m 0 -0.099 0.014 -0.198 0.042 -0.292 c 0.068 -0.382 0.112 -0.466 0.17 -0.54 c 0.229 -0.611 0.303 -0.669 0.388 -0.709 c 0.486 -0.754 0.593 -0.776 0.701 -0.773 c 0.845 -0.78 0.987 -0.742 1.107 -0.664 c 1.216 -0.582 1.296 -0.468 1.336 -0.337 c 1.88 -0.337 l 1.827 -0.603 1.674 -0.838 1.456 -0.996 c 1.349 -1.073 1.231 -1.131 1.105 -1.169 c 0.973 -1.208 0.836 -1.228 0.699 -1.227 c 0.512 -1.23 0.327 -1.196 0.154 -1.126 c 0.003 -1.066 -0.133 -0.973 -0.244 -0.855 c -0.356 -0.73 -0.44 -0.583 -0.491 -0.422 c -0.548 -0.243 -0.576 -0.056 -0.574 0.133 c -0.575 0.313 -0.546 0.493 -0.486 0.664 c -0.426 0.826 -0.336 0.974 -0.221 1.102 c 0.002 1.374 0.334 1.532 0.685 1.535 c 0.877 1.539 1.067 1.495 1.238 1.408 c 1.396 1.326 1.535 1.209 1.644 1.067 c 1.753 0.922 1.833 0.757 1.878 0.582 c 1.927 0.396 1.939 0.203 1.915 0.013 c -0.002 0.013 l 0 0 l 1.341 0.377 m 1.335 0.468 1.315 0.557 1.283 0.643 c 1.253 0.724 1.209 0.798 1.153 0.863 c 1.096 0.926 1.027 0.978 0.951 1.014 c 0.868 1.054 0.777 1.074 0.685 1.073 c 0.594 1.073 0.504 1.055 0.419 1.02 c 0.339 0.986 0.267 0.937 0.207 0.874 c 0.147 0.81 0.099 0.735 0.066 0.653 c 0.031 0.569 0.011 0.479 0.008 0.388 c 1.349 0.388 l h f Q q 1 0 0 1 423.5192 730.7994 cm 0 0 m 0.002 -0.142 0.073 -0.274 0.191 -0.353 c 0.312 -0.423 0.45 -0.458 0.59 -0.454 c 0.651 -0.458 0.711 -0.458 0.773 -0.454 c 0.839 -0.447 0.904 -0.43 0.967 -0.406 c 1.024 -0.385 1.075 -0.349 1.116 -0.303 c 1.155 -0.252 1.174 -0.189 1.168 -0.125 c 1.166 -0.057 1.138 0.008 1.089 0.056 c 1.033 0.107 0.967 0.146 0.895 0.17 c 0.809 0.201 0.72 0.226 0.629 0.245 c 0.329 0.33 l 0.224 0.352 0.121 0.38 0.019 0.415 c -0.076 0.446 -0.166 0.491 -0.247 0.55 c -0.327 0.608 -0.391 0.683 -0.436 0.771 c -0.486 0.873 -0.511 0.986 -0.507 1.1 c -0.512 1.226 -0.475 1.351 -0.404 1.456 c -0.333 1.551 -0.243 1.63 -0.138 1.687 c -0.028 1.747 0.092 1.788 0.215 1.809 c 0.337 1.832 0.462 1.843 0.587 1.843 c 0.716 1.844 0.845 1.83 0.972 1.801 c 1.09 1.774 1.202 1.727 1.304 1.663 c 1.404 1.598 1.488 1.513 1.551 1.413 c 1.621 1.3 1.663 1.173 1.676 1.041 c 1.076 1.041 l 1.059 1.155 0.989 1.253 0.887 1.307 c 0.78 1.355 0.665 1.38 0.547 1.378 c 0.5 1.381 0.452 1.381 0.403 1.378 c 0.35 1.373 0.298 1.36 0.247 1.341 c 0.2 1.325 0.157 1.297 0.122 1.262 c 0.087 1.224 0.069 1.174 0.071 1.124 c 0.069 1.058 0.096 0.995 0.146 0.951 c 0.202 0.903 0.267 0.866 0.337 0.842 c 0.424 0.811 0.512 0.786 0.603 0.768 c 0.917 0.701 l 1.021 0.678 1.124 0.65 1.224 0.616 c 1.319 0.584 1.409 0.539 1.49 0.481 c 1.662 0.359 1.762 0.16 1.755 -0.05 c 1.76 -0.189 1.723 -0.326 1.649 -0.443 c 1.582 -0.551 1.491 -0.642 1.384 -0.709 c 1.267 -0.778 1.14 -0.827 1.007 -0.855 c 0.873 -0.885 0.735 -0.9 0.598 -0.9 c 0.443 -0.902 0.29 -0.883 0.141 -0.845 c 0.01 -0.812 -0.114 -0.753 -0.223 -0.674 c -0.324 -0.601 -0.407 -0.504 -0.465 -0.393 c -0.527 -0.269 -0.559 -0.131 -0.558 0.008 c 0.019 0.008 l 0 0 l f Q 0.146 0.941 0.992 0.044 k q 1 0 0 1 372.9062 729.3892 cm 0 0 m 3.612 2.406 l 3.612 5.296 l 0 5.296 l h f Q 0 0.889 0.676 0 k q 1 0 0 1 376.5186 729.3892 cm 0 0 m -3.612 2.406 l -3.612 5.296 l 0 5.296 l h f Q 0.694 0.076 0.209 0 k q 1 0 0 1 374.7125 735.3145 cm 0 0 m -2.2 0 -3.984 -1.784 -3.984 -3.984 c -3.984 -6.184 -2.2 -7.968 0 -7.968 c 2.2 -7.968 3.984 -6.184 3.984 -3.984 c 3.984 -1.784 2.2 0 0 0 c 0 -6.993 m -1.662 -6.993 -3.009 -5.646 -3.009 -3.984 c -3.009 -2.322 -1.662 -0.975 0 -0.975 c 1.662 -0.975 3.009 -2.322 3.009 -3.984 c 3.009 -5.646 1.662 -6.993 0 -6.993 c f Q 0 0.235 0.86 0 k q 1 0 0 1 376.9137 729.2803 cm 0 0 m -1.118 -1.208 -3.015 -1.281 -4.237 -0.159 c -5.159 0.688 -5.459 2.005 -4.999 3.156 c -5.833 3.687 l -6.736 1.681 -5.843 -0.679 -3.836 -1.582 c -2.218 -2.311 -0.312 -1.881 0.836 -0.528 c 0 0 l f Q 0 0 0 0.6 k q 1 0 0 1 369.1348 736.8087 cm 0 0 m -0.238 0 -0.432 -0.193 -0.432 -0.432 c -0.432 -10.524 l -0.432 -10.763 -0.238 -10.956 0 -10.956 c 57.901 -10.956 l 58.139 -10.956 58.333 -10.763 58.333 -10.524 c 58.333 -0.432 l 58.333 -0.193 58.139 0 57.901 0 c h 57.901 -11.155 m 0 -11.155 l -0.348 -11.155 -0.631 -10.872 -0.631 -10.524 c -0.631 -0.432 l -0.631 -0.084 -0.348 0.199 0 0.199 c 57.901 0.199 l 58.249 0.199 58.532 -0.084 58.532 -0.432 c 58.532 -10.524 l 58.532 -10.872 58.249 -11.155 57.901 -11.155 c f Q EMC Q endstream endobj 1089 0 obj <> endobj 1092 0 obj <>stream Adobe Illustrator CS6 (Windows) 2021-04-12T11:45:36+05:00 2021-06-02T10:28:09+05:00 2021-06-02T10:28:09+05:00 1 False False 20.868494 3.999928 Millimeters Cyan Magenta Yellow Black Default Swatch Group 0 C=0 M=24 Y=86 K=0 PROCESS 100.000000 CMYK 0.000000 23.504999 86.022697 0.000000 C=69 M=8 Y=21 K=0 PROCESS 100.000000 CMYK 69.369003 7.635600 20.892700 0.000000 C=0 M=89 Y=68 K=0 PROCESS 100.000000 CMYK 0.000000 88.946404 67.623398 0.000000 C=15 M=94 Y=99 K=4 PROCESS 100.000000 CMYK 14.578501 94.070297 99.160698 4.416000 C=0 M=0 Y=0 K=84 PROCESS 100.000000 CMYK 0.000000 0.000000 0.000000 84.000000 C=0 M=0 Y=0 K=35 PROCESS 100.000000 CMYK 0.000000 0.000000 0.000000 35.000000 C=0 M=0 Y=0 K=60 PROCESS 100.000000 CMYK 0.000000 0.000000 0.000000 60.000004 Document application/pdf proof:pdf xmp.did:804244B35A9BEB118A6FC3C256996E2F uuid:08e30110-bdb7-4606-97ca-63fb62cbcecc uuid:21079f76-f6d7-4329-b725-f2fb35af5114 uuid:722f8893-0b3c-4402-87fb-c713f1fa0e26 uuid:21079f76-f6d7-4329-b725-f2fb35af5114 uuid:21079f76-f6d7-4329-b725-f2fb35af5114 proof:pdf saved xmp.iid:804244B35A9BEB118A6FC3C256996E2F 2021-04-12T11:45:42+05:00 Adobe Illustrator CS6 (Windows) / endstream endobj 1091 0 obj <>/Border[0 0 0]/H/N/Rect[366.504 739.008 429.659 723.67]/Subtype/Link/Type/Annot>> endobj 1093 0 obj <> endobj 1085 0 obj [1094 0 R 1095 0 R 1096 0 R 1097 0 R 1098 0 R 1099 0 R 1100 0 R 1101 0 R 1102 0 R 1103 0 R 1104 0 R 1105 0 R 1106 0 R 1107 0 R 1108 0 R 1109 0 R 1110 0 R 1111 0 R 1112 0 R 1113 0 R 1114 0 R] endobj 1086 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.202 Tw 8 0 0 8 70.8661 731.2159 Tm [(P)30(er)-37(ianal A)-14(bscess Cav)-16(i)-23.9(t)-32(ies \(PP)25(A)16.1(C2\): r)-33(and)-16(omized cl)-31(inical tr)-37(ial. )]TJ /T1_1 1 Tf (Br J )Tj 0 Tw 0 -1.25 TD (Surg)Tj /T1_0 1 Tf -0.023 Tw [(. 2022 Sep 9;109\(10\):951\226957. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw [(10.1093/bjs/zna)-17(c225)]TJ 0 0 0 1 k /GS1 gs -0.023 Tw ( PMID: )Tj 0.023 Tw T* (35929816; PMCID: PMC10364677.)Tj 0.102 Tw T* (20.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(S)-24(chniewind)]TJ /Span<>> BDC ( )Tj EMC 4.97 0 Td [(B, )0.6(S)-24(chafma)15(yer)]TJ /Span<>> BDC ( )Tj EMC 6.017 0 Td [(C, )0.6(V)29(on )0.5(S)-24(ch\366nfels)]TJ /Span<>> BDC ( )Tj EMC 7.037 0 Td [(W, )0.6(e)-12(t)]TJ /Span<>> BDC ( )Tj EMC 2.389 0 Td [(al. )0.6(T)50(r)-24(ea)15(tment )]TJ 0.01 Tc 0.369 Tw -22.209 -1.25 Td [(of Com)10.1(pl)-30.8(ica)15.1(ted Anal F)-18.9(istul)-15.8(a b)12.1(y an End)-15.9(of)-27.8(istul)-15.9(ar P)10.2(ol)35.1(yur)-23.9(e)-11.8(t)-12.9(hane-)]TJ 0 Tc 0.279 Tw T* [(Sponge )0.5(V)25(a)-17.1(cuum )0.5(T)47(her)-33(apy: )0.5(A )0.5(P)-24(il)30(o)17(t S)15(tud)17.1(y. )]TJ /T1_1 1 Tf [(Dis )0.5(Colon )0.5(R)21(ectum.)]TJ /T1_0 1 Tf [( )0.5(2018 )]TJ 0.019 Tc 0.669 Tw T* [(D)0.5(e)0.6(c)0.5(;)0.5(6)0.6(1)0.5(\()0.5(1)0.6(2)0.5(\))0.5(:)0.6(1)0.5(4)0.5(3)0.5(5)0.6(\226)0.5(1)0.5(4)0.6(4)0.5(1)0.5(.)0.6( d)-15.5(o)0.6(i)0.5(:)]TJ /Span<>> BDC 12.633 0 Td ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs -0.019 Tw [(1)0.6(0)0.5(.)0.5(1)0.6(0)0.5(9)0.5(7)0.5(/)0.6(D)0.5(C)0.5(R)0.6(.)0.5(0)0.6(0)0.5(0)0.5(0)0.5(0)0.6(0)0.5(0)0.5(0)0.5(0)0.6(0)0.5(0)0.5(0)0.6(1)0.5(2)0.5(3)0.5(3)]TJ 0 0 0 1 k /GS1 gs 0 Tc 0 Tw 15.005 0 Td ( )Tj 0.023 Tw -27.638 -1.25 Td (PMID: 30399049.)Tj 0.249 Tw T* (21.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Her)-16(mann)]TJ /Span<>> BDC ( )Tj EMC (J, Banasiewicz)Tj /Span<>> BDC ( )Tj EMC [(T, K)25(o\242od)17.1(ziejczak)]TJ /Span<>> BDC ( )Tj EMC [(B. R)10.9(ole of Assisted )]TJ -0.108 Tw 27.259 10 Td [(Cl)30(osur)-23.9(e )0.5(in )0.5(t)-13(he )0.6(Mana)-17(gement )0.6(of )0.5(Cr)-32(ohn )0.5(Anal )0.5(F)-19(istul)-15.9(as. )]TJ /T1_1 1 Tf 19.576 0 Td [(Adv )0.5(Skin )0.6(W)29(ound )0.5(Care)]TJ /T1_0 1 Tf 0 Tw (. )Tj 0.032 Tw -19.576 -1.25 Td [(2019 Jan;32\(1\):35\22640. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw [(10.1097/01.A)35.1(S)-10(W.0000547411.16017.58)]TJ 0 0 0 1 k /GS1 gs ( )Tj 0.023 Tw T* (PMID: 30540570.)Tj 0.112 Tw T* (22.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Banasiewicz)Tj /Span<>> BDC ( )Tj EMC [(T, Her)-16(mann)]TJ /Span<>> BDC ( )Tj EMC [(J, Kr)-31.9(oko)-14(wicz)]TJ /Span<>> BDC ( )Tj EMC [(L, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. \231Sand)-17(wich tech)]TJ 0 Tw (-)Tj 0.201 Tw -1.796 -1.25 Td [(nique\232 wi)-24(t)-13(h br)-37(idging, a modif)-28(ica)15(t)-32(ion of nega)15(t)-32(i)-15.9(ve p)25(r)-24(essur)-23.9(e w)-14(ound )]TJ 0.296 Tw T* [(t)-13(her)-32.9(apy for anal f)-27.9(istul)-16(as. )]TJ /T1_1 1 Tf [(T)54(ech )0.5(Colop)46(roctol.)]TJ /T1_0 1 Tf ( 2015 Mar;19\(3\):173\226)Tj 0.004 Tc 0.35 Tw T* [(5. d)-16.3(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs -0.004 Tw (10.1007/s10151-014-1247-4)Tj 0 0 0 1 k /GS1 gs 0.35 Tw [( Epub 2014 N)-14.3(ov 18. PMID:)4( )]TJ 0 Tc 0 Tw T* (25403770.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 70.936 615.2279 Tm (REFERENCES)Tj 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0 Tc 0.34 Tw 8 0 0 8 70.8661 602.3932 Tm (1.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Har)-10(sh)]TJ /Span<>> BDC ( )Tj EMC (G, Guillem)Tj /Span<>> BDC ( )Tj EMC [(JG, S)15(tuar)-22(t)]TJ /Span<>> BDC ( )Tj EMC [(HQ, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Anor)-24(ec)-16(t)15(al Disease in )]TJ 0.015 Tc 0.557 Tw -1.296 -1.25 Td [(Neutr)-32.2(openic L)34.8(euk)9.8(emic P)39.7(a)14.8(t)-32.2(ients. Oper)-33.2(a)14.7(t)-32.2(i)-16.3(ve vs. N)-14.2(onoper)-33.2(a)14.7(t)-32.2(i)-16.3(ve)15( )]TJ 0 Tc 0 Tw T* [(Mana)-17(gement. )]TJ /T1_1 1 Tf 0.023 Tw 5.707 0 Td [(Dis Colon R)21(ectum)]TJ /T1_0 1 Tf (. 1994;37:1095\2261099.)Tj 0.04 Tw -5.707 -1.25 Td (2.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(M)-24(or)-32(cos)]TJ /Span<>> BDC ( )Tj EMC 3.136 0 Td [(B, )0.5(Amar)-37(in)]TJ /Span<>> BDC ( )Tj EMC [(R, )0.5(A)-14(bu )0.5(Sba)]TJ /Span<>> BDC ( )Tj EMC 8.705 0 Td [(A, )0.5(e)-12(t)]TJ /Span<>> BDC ( )Tj EMC 2.115 0 Td [(al. )0.5(Contem)10(por)-32.9(ar)-24(y )0.5(mana)-17(gement )]TJ 0.186 Tw -15.253 -1.25 Td [(of )0.6(per)-37(ianal )0.5(condi)-23.9(t)-32(ions )0.6(in )0.5(febr)-36.9(ile )0.5(neutr)-31.9(openic )0.5(p)32(a)15(t)-32(ients. )]TJ /T1_1 1 Tf 23.326 0 Td [(Eur )0.6(J )0.5(Surg )]TJ 0 Tw -23.326 -1.25 Td (Oncol.)Tj /T1_0 1 Tf 0.023 Tw [( 2013;39\(4\):404\2267. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1016/j.ejso)Tj 0 0 0 1 k /GS1 gs 0.135 Tw T* (3.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (Chen)Tj /Span<>> BDC ( )Tj EMC (CY, Cheng)Tj /Span<>> BDC ( )Tj EMC (A, Huang)Tj /Span<>> BDC ( )Tj EMC [(S)-32(Y, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Cl)-31(inical and micr)-31.9(obiol)30(o)-16(gical )]TJ 0.164 Tw -1.296 -1.25 Td [(char)-33(a)-17(c)-15.9(ter)-37(ist)-32(ics of per)-37(ianal infec)-16(t)-32(ions in adul)56(t p)32(a)15(t)-31.9(ients wi)-24(t)-12.9(h a)-17(cute )]TJ 0 Tw T* [(leuk)10(emia. )]TJ /T1_1 1 Tf 0.007 Tw 4.147 0 Td (PLoS One.)Tj /T1_0 1 Tf [( 2013; 8\(4\). d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw [(10.1371/jour)-15(nal.pone.0060624)]TJ 0 0 0 1 k /GS1 gs ( )Tj 0.004 Tc -0.004 Tw -4.147 -1.25 Td [(ht)-29.6(tp://www.pl)30.4(osone.or)-31.6(ght)-29.6(tp://www.pubmedcentr)-32.6(al.)0.5(gov/t)17.5(o)-15.7(cr)-23.5(ende)0.5(r.)]TJ 0 Tc 0 Tw T* [(fcgi?jour)-14.9(nal=440)]TJ 0.13 Tw T* (4.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(S)-16(olma)-24(z)]TJ /Span<>> BDC ( )Tj EMC 3.227 0 Td [(S, )0.5(K)25(or)-21.9(ur)]TJ /Span<>> BDC ( )Tj EMC 3.536 0 Td [(A, )0.5(Ger)-23.9(ekl)-31(io\262l)35(u)]TJ /Span<>> BDC ( )Tj EMC 6.032 0 Td [(\307, )0.5(e)-12(t)]TJ /Span<>> BDC ( )Tj EMC 2.208 0 Td [(al. )0.6(Anor)-24(ec)-16(t)15(al )0.6(Com)10(pl)-31(ica)15(t)-32(ions )]TJ 0.152 Tw -16.299 -1.25 Td [(Dur)-37(ing Neutr)-32(openic P)30(er)-37(iod in P)40(a)15(t)-32(ients wi)-23.9(t)-13(h Hema)15(t)17(ol)30.1(o)-16(gic Diseases. )]TJ /T1_1 1 Tf 0.015 Tc 0.551 Tw T* [(Mediter)-16.1(r J Hematol Infect Dis)]TJ /T1_0 1 Tf [(. 2016 Mar 1;8\(1\):e2016019.)15( )]TJ 0 Tc 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.4084/MJHID.2016.019)Tj 0 0 0 1 k /GS1 gs 0.023 Tw [( eCollec)-16(t)-32(ion 2016.PMID: 26977278)]TJ -0.023 Tw -1.847 -1.25 Td (5.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (Chang)Tj /Span<>> BDC ( )Tj EMC 2.677 0 Td [(H, )0.6(K)25(uo )0.5(M-C, )0.6(T)40(ang )0.5(T-C, )0.6(e)-12(t)]TJ /Span<>> BDC ( )Tj EMC 9.434 0 Td [(al. )0.6(Cl)-31(inical )0.6(F)10(ea)15(tur)-24(es )0.6(and )0.5(R)13(ecur)-24(r)-23.9(ence )]TJ -0.008 Tw -13.407 -1.25 Td [(P)40(a)15(t)-30(ter)-14.9(n of P)30(er)-37(ianal A)-14(bscess in P)40(a)15(t)-32(ients wi)-24(t)-13(h A)-25(cute M)16(yel)30(oid L)35(euk)10(emia. )]TJ /T1_1 1 Tf 0.023 Tw T* (Acta Haematologica.)Tj /T1_0 1 Tf [( 2017, 138\(1\): 10\22613. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1159/000475589)Tj 0 0 0 1 k /GS1 gs 0.202 Tw T* (6.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(S)-16(ht)-10(yr)-23.9(kov)-15(a)]TJ /Span<>> BDC ( )Tj EMC [(S.V., Kl)35.1(y)22(asov)-15(a)]TJ /Span<>> BDC ( )Tj EMC [(G.A., K)-16(ar)-33(a)-17(g)16(yul)35(y)22(an)]TJ /Span<>> BDC ( )Tj EMC [(S.R., e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. P)30(er)-37(ianal )]TJ 0.06 Tw -1.296 -1.25 Td [(infec)-16(t)-32(ious )0.6(com)10(pl)-30.9(ica)15(t)-32(ions )0.5(in )0.6(p)32(a)15(t)-32(ions )0.6(wi)-24(t)-13(h )0.6(gr)-33(anul)30(o)-16(cy)-16(t)17.1(openia )0.5(and )0.6(ha)15(t)]TJ 0 Tw (-)Tj 0.233 Tw T* [(mo)17(t)17(ol)30(o)-16(gical )0.5(mal)-31(ignanc)-23.9(ies. )]TJ /T1_1 1 Tf 0 Tw 11.299 0 Td [(K)18(olop)46(roktologia)]TJ /T1_0 1 Tf 0.233 Tw [(. )0.5(2020;19\(4\):10\22621. )0.5(\(In )]TJ 0.023 Tw -11.299 -1.25 Td [(Russ.\). d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.33878/2073-7556-2020-19-4-10-3)Tj 0 0 0 1 k /GS1 gs -0.031 Tw T* (7.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Bolk)-24(v)-14.9(ad)17(ze)]TJ /Span<>> BDC ( )Tj EMC [(E.E., Egor)-24(k)-16(in)]TJ /Span<>> BDC ( )Tj EMC [(M.A. Cl)-16(assif)-28(ica)15.1(t)-32(ion and tr)-23.9(ea)15(tment of a)-17(cute )]TJ 0.176 Tw -1.296 -1.25 Td [(per)-37(ianal )0.6(abscesses/ )0.6(F)-19(if)-28(teen )0.6(year)-10(s )0.5(of )0.6(single )0.5(inst)-31.9(i)-24(tut)-32(ion )0.6(e)-18(xpir)-37(ience. )]TJ /T1_1 1 Tf 0 Tw T* [(K)18(olop)46(roktologia)]TJ /T1_0 1 Tf 0.023 Tw (. 2012;2:13\25716. \(in Russ.\).)Tj 0.008 Tc 0.35 Tw T* (8.)Tj /Span<>> BDC ( )Tj EMC 1.321 0 Td [(L)34.8(our)-24.2(eir)-32.2(o)]TJ /Span<>> BDC ( )Tj EMC [(RV, Bor)-32.2(ges)]TJ /Span<>> BDC ( )Tj EMC [(VP, T)44.8(om\351)]TJ /Span<>> BDC ( )Tj EMC [(AL, e)-12.3(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Anor)-24.2(ec)-16.2(t)14.8(al com)9.8(pl)-31.2(i)]TJ 0 Tc 0 Tw (-)Tj 0.011 Tc 0.423 Tw -1.321 -1.25 Td [(ca)14.6(t)-32.4(ions in p)31.6(a)14.6(t)-32.4(ients wi)-24.4(t)-13.4(h haema)14.6(t)16.6(ol)29.6(o)-16.4(gical mal)-31.4(ignanc)-24.4(ies. )]TJ /T1_1 1 Tf [(Eur J)11( )]TJ 0.397 Tw T* (Gastroenterol Hepatol. )Tj /T1_0 1 Tf [(2018 Jul;30\(7\):722\226726. d)-15.7(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs -0.011 Tw (10.1097/)Tj 0 Tc 0 Tw T* (MEG.0000000000001133)Tj 0 0 0 1 k /GS1 gs 0.058 Tw T* (9.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Andr)-24(eev)]TJ /Span<>> BDC ( )Tj EMC [(A.A., Demy)22(anov)]TJ /Span<>> BDC ( )Tj EMC [(A.V. Me)-12(t)-13(hod hyr)-32(oim)10(pulsi)-15.9(ve sana)15(t)-32(ions in )]TJ 0.089 Tw -1.296 -1.25 Td [(tr)-24(ea)15(tment of a)-17(cute p)32(ar)-33(ap)25(r)-32(o)-15.9(c)-16(t)-32(i)-24(t)-32(is. Sy)-13(stem anal)35(y)-13(sis and mana)-17(gement )]TJ 0.023 Tw T* [(of biomedical sy)-13(stems. 2014;13\(3\):677\226683. \(In Russ.\).)]TJ 0.161 Tw T* (10.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Chen)Tj /Span<>> BDC ( )Tj EMC [(SQ, L)-32(iu)]TJ /Span<>> BDC ( )Tj EMC (WC, Zhang)Tj /Span<>> BDC ( )Tj EMC [(ZZ, e)-11.9(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Appl)-31(ica)15(t)-32(ion of cl)30(osed nega)]TJ 0 Tw (-)Tj 0.286 Tw -1.796 -1.25 Td [(t)-32(i)-16(ve p)25(r)-23.9(essur)-24(e ir)-24(r)-36.9(iga)15(t)-32(ion and suc)-16(t)-32(ion dev)-15.9(ice in t)-13(he tr)-24(ea)15(tment of )]TJ 0.082 Tw T* [(high per)-37(ianal abscess. )]TJ /T1_1 1 Tf [(Zhonghua W)30.1(ei Chang W)30(ai K)22(e Za Zhi.)]TJ /T1_0 1 Tf [( 2019 Ap)25(r )]TJ 0.02 Tw 0 -1.25 Td [(25;22\(4\):364\226369. )0.5(d)-15.9(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw 9.795 0 Td (10.3760/cma.j.issn.1671-0274.2019.04.009)Tj 0 0 0 1 k /GS1 gs 0.01 Tc 0.368 Tw -9.795 -1.25 Td (11.)Tj /Span<>> BDC ( )Tj EMC 1.835 0 Td [(P)40.1(ar)-31.8(ov)-15.8(ichnikov)-14.9(a)]TJ /Span<>> BDC ( )Tj EMC [(E.N., T)50.2(r)-31.9(oi)-23.8(tsk)-16.9(a)15.2(y)22.1(a)]TJ /Span<>> BDC ( )Tj EMC [(V.V., Kl)35.1(y)22.2(asov)-14.8(a)]TJ /Span<>> BDC ( )Tj EMC [(G.A., e)-11.8(t)]TJ /Span<>> BDC ( )Tj EMC [(al.)10( )]TJ 0 Tc 0.33 Tw -1.835 -1.25 Td [(T)50(r)-24(ea)15(t)-32(ing )0.5(p)32(a)15(t)-32(ients )0.5(wi)-23.9(t)-13(ha)-17(cute )0.5(myel)30(oid )0.5(leuk)10(emias )0.6(\(AML\) )0.5(a)-17(ccor)-24(ding )]TJ 0.16 Tw T* [(t)17(o t)-13(he p)25(r)-32(o)17(t)17(o)-16(col of t)-13(he AML-01.10 Russian mul)56.1(t)-32(icenter r)-33(and)-16(omized )]TJ 0.008 Tc 0.35 Tw T* [(tr)-37.1(ial: )0.5(T)47(he )0.5(co)-16.1(or)-24(dina)15(t)-32(ing )0.5(center\245s )0.5(r)-24.1(esul)56(ts. )]TJ /T1_1 1 Tf 17.955 0 Td [(T)54(erapevticheskii )0.5(arkhiv.)]TJ /T1_0 1 Tf 0 Tc 0 Tw 9.683 0 Td ( )Tj 0.023 Tw -27.638 -1.25 Td (2014;86\(7\):14\22623. \(In Russ.\).)Tj 0.18 Tw T* (12.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Ok)10(en)]TJ /Span<>> BDC ( )Tj EMC [(MM, Cr)-24(eech)]TJ /Span<>> BDC ( )Tj EMC [(RH, T)45(or)-16(me)-11(y)]TJ /Span<>> BDC ( )Tj EMC [(DC, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. T)45(o)14(xic)-23.9(i)-24(t)-10(y and r)-24(esponse )]TJ 0.032 Tw -1.796 -1.25 Td [(cr)-37(i)-23.9(ter)-37(ia of t)-13(he Easter)-15(n Co)-16(oper)-33(a)15(t)-32(i)-15.9(ve Oncol)30(o)-16(g)16(y G)20.1(r)-32(oup. )]TJ /T1_1 1 Tf (Am J Clin Oncol.)Tj /T1_0 1 Tf 0 Tw ( )Tj 29.055 52.5 Td (1982;5\(6\):649\22655.)Tj 0.187 Tw T* (13.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Hal)-31(il)30.1(o)-16(gl)35(u)]TJ /Span<>> BDC ( )Tj EMC (N, Gulpinar)Tj /Span<>> BDC ( )Tj EMC [(B, Ozk)-17(avukcu)]TJ /Span<>> BDC ( )Tj EMC [(E, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. T)40(ypical MR ima)-16.9(g)]TJ 0 Tw (-)Tj 0.256 Tw -1.796 -1.25 Td [(ing f)-28(indings of per)-37(ianal infec)-15.9(t)-32(ions in p)32(a)15(t)-32(ients wi)-24(t)-13(h hema)15(t)17.1(ol)30(o)-16(gic )]TJ 0 Tw T* [(mal)-31(ignanc)-23.9(ies. )]TJ /T1_1 1 Tf 0.137 Tw 6.016 0 Td [(Eur J R)20(adiol)]TJ /T1_0 1 Tf [(. 2017 A)10(ug;93:284\226288. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1016/j.)Tj -6.016 -1.25 Td [(ejr)-33(ad.2017.05.046)]TJ 0 0 0 1 k /GS1 gs 0.023 Tw ( Epub 2017 Jun 3)Tj 0.061 Tw T* (14.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Pl)35(umb)]TJ /Span<>> BDC ( )Tj EMC [(AA, Hall)-30.9(igan)]TJ /Span<>> BDC ( )Tj EMC [(S, Bha)15(tna)-17(gar)]TJ /Span<>> BDC ( )Tj EMC [(G, T)40(a)15(yl)30(or)]TJ /Span<>> BDC ( )Tj EMC [(SA. P)30(er)-37(ianal Sepsis in )]TJ 0.103 Tw -1.796 -1.25 Td [(Hema)15(t)17(ol)30(o)-16(gic Mal)-30.9(ignancy: MR Ima)-17(ging Appear)-33(ances and Dist)-32(inc)-15.9(t)-32(ion )]TJ 0.009 Tc 0.349 Tw T* [(fr)-31.7(om Cr)-23.7(ypt)17.2(o)-15.7(gl)-15.8(andul)-15.8(ar Infec)-15.8(t)-31.8(ion in Immuno)-15.8(com)10.2(pe)-11.8(tent P)40.2(a)15.2(t)-31.7(ients.)9( )]TJ /T1_1 1 Tf 0 Tc 0 Tw T* [(R)20(adiology)]TJ /T1_0 1 Tf 0.167 Tw [(. 2015 Jul;276\(1\):147\22655. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw [(10.1148/r)-33(adiol.15141662)]TJ 0 0 0 1 k /GS1 gs ( )Tj 0.023 Tw T* (Epub 2015 Mar 10.PMID: 25759970)Tj 0.128 Tw T* (15.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Mar)-24(k)-10(s)]TJ /Span<>> BDC ( )Tj EMC 2.676 0 Td (G, Chase)Tj /Span<>> BDC ( )Tj EMC [(WV, Mer)-32(v)-15.9(ine)]TJ /Span<>> BDC ( )Tj EMC [(T.B. T)47(he f)16(a)15(t)15(al po)17(tent)-32(ial of f)-28(istul)-15.9(a-)]TJ 0.002 Tc 0.35 Tw -4.472 -1.25 Td [(in-ano wi)-24.1(t)-13.1(h )0.5(abscess: anal)34.9(y)-13.1(sis of 11 dea)14.9(t)-13.1(hs. )]TJ /T1_1 1 Tf [(Dis Colon R)20.9(ectum)]TJ /T1_0 1 Tf 0 Tc 0 Tw (. )Tj T* (1973;16:224\22630.)Tj 0.008 Tc 0.35 Tw T* (16.)Tj /Span<>> BDC ( )Tj EMC 1.829 0 Td [(V)28.8(o)-16.1(gel)]TJ /Span<>> BDC ( )Tj EMC (JD, Johnson)Tj /Span<>> BDC ( )Tj EMC [(EK, M)-24.2(or)-24.2(r)-37.1(is)]TJ /Span<>> BDC ( )Tj EMC [(AM, e)-12.2(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Cl)-31.2(inical P)34.8(r)-33.1(a)-17.2(c)-16.1(t)-32.2(ice)8( )]TJ 0 Tc 0.072 Tw -1.829 -1.25 Td [(Guidel)-30.9(ine for t)-12.9(he Mana)-17(gement of Anor)-24(ec)-16(t)15(al A)-14(bscess, F)-19(istul)-15.9(a-in-Ano, )]TJ 0.267 Tw T* [(and R)13(ec)-16(t)17(ov)-15(a)-16.9(ginal F)-19(istul)-16(a. )]TJ /T1_1 1 Tf [(Dis Colon R)21(ectum)]TJ /T1_0 1 Tf (. 2016 ;59\(12\):1117\226)Tj 0.023 Tw T* (1133. PMID: 27824697)Tj 0.051 Tw T* (17.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Mudr)-32(ov)]TJ /Span<>> BDC ( )Tj EMC 3.26 0 Td [(A.A., )0.5(Omar)-32(ov)-15(a)]TJ /Span<>> BDC ( )Tj EMC [(M.M., )0.5(F)10(omenko)]TJ /Span<>> BDC ( )Tj EMC [(O.Y., )0.5(e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. )0.5(Sur)-32(gical tr)-23.9(ea)15(t)]TJ 0 Tw (-)Tj 0.128 Tw -5.056 -1.25 Td [(ment )0.5(of )0.5(r)-24(ec)-16(t)17(ov)-15(a)-16.9(ginal f)-28(istul)-15.9(a )0.5(wi)-24(t)-13(h )0.5(v)-15(a)-17(ginal )0.5(r)-23.9(ec)-16(t)15(angul)-16(ar )0.5(fl)-16(ap. )]TJ /T1_1 1 Tf 0 Tw 24.706 0 Td (Pirogov )Tj 0.282 Tw -24.706 -1.25 Td [(R)22(ussian Jour)-13.9(nal of Surg)12(er)-43(y)]TJ /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC [(Khirurgiya. Zur)-14(nalim. N.I. Pirogov)16.1(a.)]TJ /T1_0 1 Tf 0 Tw ( )Tj 0.023 Tw T* [(2021;07:5\22611. \(In Russ.\). d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw [(10.17116/hir)-22(ur)-32(gia20210715)]TJ 0 0 0 1 k /GS1 gs 0.007 Tc 0.349 Tw T* (18.)Tj /Span<>> BDC ( )Tj EMC 1.823 0 Td [(S)-15.8(hal)-15.8(ab)12.1(y)]TJ /Span<>> BDC ( )Tj EMC (M, Emile)Tj /Span<>> BDC ( )Tj EMC [(S, Elfek)-15.9(i)]TJ /Span<>> BDC ( )Tj EMC [(H, e)-11.8(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Sy)-12.8(stema)15.1(t)-31.8(ic r)-23.7(ev)-15.8(iew of)7( )]TJ 0.006 Tc -1.823 -1.25 Td [(end)-15.9(ol)35(uminal v)-14.9(a)-17(cuum-assisted t)-13(her)-33(apy as sal)30(v)-14.9(a)-16.9(ge tr)-23.9(ea)15(tment for)6( )]TJ 0 Tc 0.138 Tw T* [(r)-24(ec)-15.9(t)15(al anast)17(omo)17(t)-32(ic leak)-17(a)-17(ge. )]TJ /T1_1 1 Tf (BJS Open)Tj /T1_0 1 Tf (. 2018 Dec 26;3\(2\):153\226160. )Tj 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1002/bjs5.50124)Tj 0 0 0 1 k /GS1 gs 0.023 Tw ( PMID: 30957061; PMCID: PMC6433422.)Tj 0.164 Tw -1.847 -1.25 Td (19.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(New)-24(t)17(on)]TJ /Span<>> BDC ( )Tj EMC [(K, P)30(ear)-31.9(ce)]TJ /Span<>> BDC ( )Tj EMC [(L, Br)-37(iggs)]TJ /Span<>> BDC ( )Tj EMC [(M, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. P)10(ost)17(oper)-33(a)15(t)-31.9(i)-16(ve P)40(a)-17(ck)-16(ing of )]TJ 0.202 Tw -1.796 -1.25 Td [(P)30(er)-37(ianal A)-14(bscess Cav)-16(i)-23.9(t)-32(ies \(PP)25(A)16.1(C2\): r)-33(and)-16(omized cl)-31(inical tr)-36.9(ial. )]TJ /T1_1 1 Tf (Br J )Tj 0 Tw T* (Surg)Tj /T1_0 1 Tf -0.023 Tw [(. 2022 Sep 9;109\(10\):951\226957. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw [(10.1093/bjs/zna)-17(c225)]TJ 0 0 0 1 k /GS1 gs -0.023 Tw ( PMID: )Tj 0.023 Tw T* (35929816; PMCID: PMC10364677.)Tj 0.102 Tw T* (20.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(S)-24(chniewind)]TJ /Span<>> BDC ( )Tj EMC 4.97 0 Td [(B, )0.6(S)-24(chafma)15(yer)]TJ /Span<>> BDC ( )Tj EMC 6.017 0 Td [(C, )0.6(V)29(on )0.5(S)-24(ch\366nfels)]TJ /Span<>> BDC ( )Tj EMC 7.037 0 Td [(W, )0.6(e)-12(t)]TJ /Span<>> BDC ( )Tj EMC 2.389 0 Td [(al. )0.6(T)50(r)-24(ea)15(tment )]TJ 0.01 Tc 0.369 Tw -22.209 -1.25 Td [(of Com)10.1(pl)-30.8(ica)15.1(ted Anal F)-18.9(istul)-15.8(a b)12.1(y an End)-15.9(of)-27.8(istul)-15.9(ar P)10.2(ol)35.1(yur)-23.9(e)-11.8(t)-12.9(hane-)]TJ 0 Tc 0.279 Tw T* [(Sponge )0.5(V)25(a)-17.1(cuum )0.5(T)47(her)-33(apy: )0.5(A )0.5(P)-24(il)30(o)17(t S)15(tud)17.1(y. )]TJ /T1_1 1 Tf [(Dis )0.5(Colon )0.5(R)21(ectum.)]TJ /T1_0 1 Tf [( )0.5(2018 )]TJ 0.019 Tc 0.669 Tw T* [(D)0.5(e)0.6(c)0.5(;)0.5(6)0.6(1)0.5(\()0.5(1)0.6(2)0.5(\))0.5(:)0.6(1)0.5(4)0.5(3)0.5(5)0.6(\226)0.5(1)0.5(4)0.6(4)0.5(1)0.5(.)0.6( d)-15.5(o)0.6(i)0.5(:)]TJ /Span<>> BDC 12.633 0 Td ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs -0.019 Tw [(1)0.6(0)0.5(.)0.5(1)0.6(0)0.5(9)0.5(7)0.6(/)0.5(D)0.5(C)0.5(R)0.6(.)0.5(0)0.6(0)0.5(0)0.5(0)0.5(0)0.6(0)0.5(0)0.5(0)0.6(0)0.5(0)0.5(0)0.5(0)0.6(1)0.5(2)0.5(3)0.6(3)]TJ 0 0 0 1 k /GS1 gs 0 Tc 0 Tw 15.005 0 Td ( )Tj 0.023 Tw -27.638 -1.25 Td (PMID: 30399049.)Tj 0.205 Tw T* (21.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Her)-16(mann)]TJ /Span<>> BDC ( )Tj EMC (J, Banasiewicz)Tj /Span<>> BDC ( )Tj EMC [(T, K)25(o\242od)17(ziejczak)]TJ /Span<>> BDC ( )Tj EMC [(B. R)11(ole of -Assisted )]TJ -0.108 Tw -1.796 -1.25 Td [(Cl)30(osur)-23.9(e )0.5(in )0.5(t)-13(he )0.6(Mana)-17(gement )0.6(of )0.5(Cr)-32(ohn )0.5(Anal )0.5(F)-19(istul)-15.9(as. )]TJ /T1_1 1 Tf 19.576 0 Td [(Adv )0.5(Skin )0.6(W)29(ound )0.5(Care)]TJ /T1_0 1 Tf 0 Tw (. )Tj 0.032 Tw -19.576 -1.25 Td [(2019 Jan;32\(1\):35\22640. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw [(10.1097/01.A)35.1(S)-10(W.0000547411.16017.58)]TJ 0 0 0 1 k /GS1 gs ( )Tj 0.023 Tw T* (PMID: 30540570.)Tj 0.112 Tw T* (22.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Banasiewicz)Tj /Span<>> BDC ( )Tj EMC [(T, Her)-16(mann)]TJ /Span<>> BDC ( )Tj EMC [(J, Kr)-31.9(oko)-14(wicz)]TJ /Span<>> BDC ( )Tj EMC [(L, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. \231Sand)-17(wich tech)]TJ 0 Tw (-)Tj 0.201 Tw -1.796 -1.25 Td [(nique\232 wi)-24(t)-13(h br)-37(idging, a modif)-28(ica)15(t)-32(ion of nega)15(t)-32(i)-15.9(ve p)25(r)-24(essur)-23.9(e w)-14(ound )]TJ 0.296 Tw T* [(t)-13(her)-32.9(apy for anal f)-27.9(istul)-16(as. )]TJ /T1_1 1 Tf [(T)54(ech )0.5(Colop)46(roctol.)]TJ /T1_0 1 Tf ( 2015 Mar;19\(3\):173\226)Tj 0.004 Tc 0.35 Tw T* [(5. d)-16.3(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs -0.004 Tw (10.1007/s10151-014-1247-4)Tj 0 0 0 1 k /GS1 gs 0.35 Tw [( Epub 2014 N)-14.3(ov 18. PMID:)4( )]TJ 0 Tc 0 Tw T* (25403770.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\033\030\031\030\213\b)-20.9(\035\231\213\233\t \021\032)50(\b)42(\032\231\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj -51.938 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 23, \023\0221)69(, 202)69(4)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 23, \023\0221)69(, 202)69(4)]TJ /T1_4 1 Tf 25 0 0 25 20.7902 56.0378 Tm (128)Tj ET endstream endobj 1094 0 obj <>/Border[0 0 0]/H/N/Rect[201.415 728.512 271.054 719.056]/Subtype/Link/Type/Annot>> endobj 1095 0 obj <>/Border[0 0 0]/H/N/Rect[179.3 678.512 291.968 669.216]/Subtype/Link/Type/Annot>> endobj 1096 0 obj <>/Border[0 0 0]/H/N/Rect[395.458 728.512 524.409 719.216]/Subtype/Link/Type/Annot>> endobj 1097 0 obj <>/Border[0 0 0]/H/N/Rect[331.996 678.512 426.324 669.216]/Subtype/Link/Type/Annot>> endobj 1098 0 obj <>/Border[0 0 0]/H/N/Rect[171.032 559.689 218.624 550.233]/Subtype/Link/Type/Annot>> endobj 1099 0 obj <>/Border[0 0 0]/H/N/Rect[190.473 529.689 291.968 520.233]/Subtype/Link/Type/Annot>> endobj 1100 0 obj <>/Border[0 0 0]/H/N/Rect[85.6442 469.689 169.564 460.393]/Subtype/Link/Type/Annot>> endobj 1101 0 obj <>/Border[0 0 0]/H/N/Rect[223.694 439.689 289.606 430.233]/Subtype/Link/Type/Annot>> endobj 1102 0 obj <>/Border[0 0 0]/H/N/Rect[109.974 399.689 232.781 390.393]/Subtype/Link/Type/Annot>> endobj 1103 0 obj <>/Border[0 0 0]/H/N/Rect[261.458 339.689 291.968 330.233]/Subtype/Link/Type/Annot>> endobj 1104 0 obj <>/Border[0 0 0]/H/N/Rect[70.8661 329.689 150.73 320.393]/Subtype/Link/Type/Annot>> endobj 1105 0 obj <>/Border[0 0 0]/H/N/Rect[149.226 259.689 291.968 250.393]/Subtype/Link/Type/Annot>> endobj 1106 0 obj <>/Border[0 0 0]/H/N/Rect[489.898 579.689 524.409 570.233]/Subtype/Link/Type/Annot>> endobj 1107 0 obj <>/Border[0 0 0]/H/N/Rect[303.307 569.689 362.867 560.393]/Subtype/Link/Type/Annot>> endobj 1108 0 obj <>/Border[0 0 0]/H/N/Rect[441.338 529.689 524.409 520.233]/Subtype/Link/Type/Annot>> endobj 1109 0 obj <>/Border[0 0 0]/H/N/Rect[404.291 409.689 496.139 400.393]/Subtype/Link/Type/Annot>> endobj 1110 0 obj <>/Border[0 0 0]/H/N/Rect[318.085 369.689 383.709 360.393]/Subtype/Link/Type/Annot>> endobj 1111 0 obj <>/Border[0 0 0]/H/N/Rect[433.856 339.689 503.495 330.233]/Subtype/Link/Type/Annot>> endobj 1112 0 obj <>/Border[0 0 0]/H/N/Rect[411.741 289.689 524.409 280.393]/Subtype/Link/Type/Annot>> endobj 1113 0 obj <>/Border[0 0 0]/H/N/Rect[395.458 249.689 524.409 240.393]/Subtype/Link/Type/Annot>> endobj 1114 0 obj <>/Border[0 0 0]/H/N/Rect[331.996 199.689 426.324 190.393]/Subtype/Link/Type/Annot>> endobj 1135 0 obj <> endobj 1134 0 obj <> endobj 1133 0 obj <> endobj 1132 0 obj <> endobj 1131 0 obj <> endobj 1130 0 obj <> endobj 1129 0 obj <> endobj 1128 0 obj <> endobj 1127 0 obj <> endobj 1126 0 obj <> endobj 1125 0 obj <> endobj 1124 0 obj <> endobj 1123 0 obj <> endobj 1122 0 obj <> endobj 1121 0 obj <> endobj 1120 0 obj <> endobj 1119 0 obj <> endobj 1118 0 obj <> endobj 1117 0 obj <> endobj 1116 0 obj <> endobj 1115 0 obj <> endobj 1083 0 obj [1136 0 R 1137 0 R 1138 0 R 1139 0 R 1140 0 R 1141 0 R 1142 0 R 1143 0 R 1144 0 R 1145 0 R 1146 0 R 1147 0 R 1148 0 R 1149 0 R] endobj 1084 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\255\220\013\202\001\025\006)-9.9(\026\220\n\013 \220\022\007\016\017\016\001\220\016 \006)-10(\007\025\217\001\020\207 \225\025\002\024 \025\006)-10(\026\002\025\202)10(\025 \221\013\002\013\221\002\025\n)-10(\026\220\026)11(\013 )]TJ 0 -1 TD [(\215\022\221\013\227\220\016\001\026)11.1(\025\r \006\022\025\221\215)21(\207\025\007\016\r\020\024\220 \222\013\f\025\007\016\r\013\001\220\205\024\ \220 \006\220\006)-10(\026)11(\016\024\020 \n\002\025\r\220)]TJ 40.547 1 Td [(Diagnostics and tr)31(eatment of complicated perianal )]TJ 0.208 -1 Td [(abscess in patients with h)11(ematologic malignancies)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0.023 Tw 10 0 0 10 42.5197 724.8299 Tm (AUTHORS CONTRIBUTION)Tj /T1_2 1 Tf -0.006 Tw 0 -1.218 TD [(C)-6.5(o)0.8(nce)-0.7(p)-12.3(t a)2.4(n)-4.6(d d)-5.5(e)-13.3(s)-16.6(i)3.2(g)1.2(n o)-2.1(f t)-16.7(h)-5.3(e s)-20(t)-12.8(ud)-10.9(y)-11.8(:)]TJ /T1_3 1 Tf [( S)16.7(v)6.6(e)-4.4(tl)3.3(a)-0.7(n)4.8(a)]TJ /Span<>> BDC ( )Tj EMC [(V)53.1(.)]TJ /Span<>> BDC ( )Tj EMC [(S)15.3(h)3.8(t)-30(y)-2(r)-2.4(k)12.9(o)-0.6(v)10.8(a)-14(, )]TJ -0.006 Tc 0.006 Tw T* [(K)6.8(a)-5.8(r)-3.6(e)-8.5(n)]TJ /Span<>> BDC 2.232 0 Td ( )Tj EMC [(I)-3.6(.)]TJ /Span<>> BDC 0.864 0 Td ( )Tj EMC [(Nt)-3.7(a)-6.8(ni)5(s)3.6(hy)-2.2(a)-6.8(n)]TJ /T1_2 1 Tf 0 Tc 1.014 Tw -3.096 -1.218 Td [(C)-6.5(o)-5.8(l)-19(l)-14.3(e)-9.4(c)-32.5(t)-37.3(i)3.2(o)0.8(n )0.5(a)2.4(n)-4.6(d )0.6(p)-3.8(r)-6(o)-7(ce)-13.3(s)-12.8(s)-16.6(i)7.1(n)-1.9(g )0.6(o)-2.2(f )0.6(t)-16.7(h)-5.3(e )0.5(m)1.8(a)-8.4(t)-15.1(e)-2.1(r)-48(i)5.1(a)-1.5(l)-22.5(:)]TJ /T1_3 1 Tf 0 Tw ( )Tj T* [(S)16.7(v)6.6(e)-4.4(tl)3.3(a)-0.8(n)4.8(a)]TJ /Span<>> BDC ( )Tj EMC [(V)53.2(.)]TJ /Span<>> BDC ( )Tj EMC [(S)15.3(h)3.8(t)-30(y)-2(r)-2.5(k)12.9(o)-0.6(v)10.9(a)-14(, O)-7.4(l)4.7(ga)]TJ /Span<>> BDC ( )Tj EMC [(A)-12.6(.)]TJ /Span<>> BDC ( )Tj EMC [(S)5.6(o)2(b)-5.9(o)-1.1(l)4.8(e)-4(v)10.8(a)-14(, K)11(i)9.4(r)-35.3(i)7.4(ll)]TJ /Span<>> BDC ( )Tj EMC [(R)-2.5(.)]TJ /Span<>> BDC ( )Tj EMC [(S)9.1(a)3.5(b)3.3(i)9.4(r)2.4(o)-0.6(v)]TJ /T1_2 1 Tf 0.895 Tw T* [(W)3.1(r)-48(i)-6(t)-37.4(i)7.1(n)-1.9(g o)-2.2(f t)-16.7(h)-5.3(e t)-15.2(e)-23.9(x)-35.9(t)-20.1(:)]TJ /T1_3 1 Tf [( S)16.7(v)6.6(e)-4.4(tl)3.3(a)-0.8(n)4.8(a)]TJ /Span<>> BDC ( )Tj EMC [(V)53.1(.)]TJ /Span<>> BDC ( )Tj EMC [(S)15.3(h)3.8(t)-30(y)-2(r)-2.4(k)12.9(o)-0.6(v)10.8(a)-14(, )]TJ 0 Tw 0 -1.218 TD [(O)-7.4(l)4.7(ga)]TJ /Span<>> BDC ( )Tj EMC [(A)-12.5(.)]TJ /Span<>> BDC ( )Tj EMC [(S)5.6(o)2(b)-5.9(o)-1.1(l)4.8(e)-4(v)10.8(a)-13.9(, K)10.9(i)9.4(r)-35.3(i)7.4(ll)]TJ /Span<>> BDC ( )Tj EMC [(R)-2.4(.)]TJ /Span<>> BDC ( )Tj EMC [(S)9(a)3.5(b)3.3(i)9.4(r)2.4(o)-0.6(v)]TJ /T1_2 1 Tf 0.006 Tc -0.006 Tw 0 -1.218 TD [(E)11.6(dit)-31.4(i)13.1(n)4.1(g)15(:)]TJ /T1_3 1 Tf 0 Tc 0.28 Tw 3.238 0 Td [( K)12.8(ar)2.4(e)-2.6(n)]TJ /Span<>> BDC ( )Tj EMC [(I)2.4(.)]TJ /Span<>> BDC ( )Tj EMC [(N)5.6(t)2.3(a)-0.8(n)6.2(i)11(s)9.6(h)5.7(y)3.8(a)-0.8(n)-6(, V)-8.9(y)3.8(a)-5(c)1.8(h)1.9(e)-18(s)9.3(l)3.3(a)-4.4(v)]TJ /Span<>> BDC ( )Tj EMC [(A)-12.6(.)]TJ /Span<>> BDC ( )Tj EMC [(N)2.3(ov)-28.6(i)7.9(k)12.9(o)-0.6(v)33.6(, )]TJ -0.005 Tc 0.005 Tw -3.238 -1.218 Td [(E)14.6(le)-7.6(na)]TJ /Span<>> BDC 2.132 0 Td ( )Tj EMC [(N)8(.)]TJ /Span<>> BDC 1.088 0 Td ( )Tj EMC [(P)25.8(a)-4.8(r)-2.6(o)-5.6(v)-33.6(i)-2.4(c)-3.2(hn)1.2(i)2.9(k)8(o)-5.6(v)5.7(a)]TJ /T1_1 1 Tf 0 Tc 0.023 Tw -3.22 -2.436 Td (\255\026\036\031\036\025\034\224 \017\225 \032\026\020\017\022\032\221 \(\ ORCID\))Tj /T1_2 1 Tf 0.484 Tw T* (\234\021\t\030\022\024\r\026 \221\r\036\021\035\026\027\026 \200\017\021\ \026\035\034\036\r\027\026)Tj /Span<>> BDC ( )Tj EMC (\227 \022.\n.\027., \r\030\026\004-)Tj 0.793 Tw 0 -1.218 TD (\022\024\035\024\023\030\024\022\021\024\035\024\020 \b\017\030\031\030\020\ \017\004\036\f\022\024\020\024 \024\021\007\036\035\036\027\017\016 \205\ \206\207\211 )Tj 0.512 Tw 0 -1.218 TD [(\253\203\204\222\037 \020\036\n\026\021\024\035\024\020\017\017\273 )0.5(\204\017\027\007\030\026\r\026 \217\024\f\f\017\017; ORCID: )]TJ 0 Tw 0 -1.218 TD (0000-0002-4272-8433 SPIN-\022\024\007 2900\2265883)Tj 0.242 Tw T* (\221\024\002\024\035\036\r\026 \210\035\034\020\026 \202\035\036\022\f\036\ \036\r\027\026)Tj /Span<>> BDC ( )Tj EMC (\227 \r\030\026\004-\b\017\030\031\030\020 \b\017\030\031\030)Tj 0 Tw (-)Tj 0.52 Tw T* [(\020\017\004\036\f\022\024\020\024 \024\021\007\036\035\036\027\017\016 \ )0.5(\205\206\207\211 \253\203\204\222\037 \020\036\n\026\021\024\035\024\020\ \017\017\273 )]TJ 0 Tw T* (\204\017\027\007\030\026\r\026 \217\024\f\f\017\017; ORCID: 0000-0001-9\ 879-2664)Tj 0.178 Tw T* (\221\026\002\017\030\024\r \025\017\030\017\035\035 \217\031\f\021\036\n\ \024\r\017\004)Tj /Span<>> BDC ( )Tj EMC (\227 \r\030\026\004-\b\017\030\031\030\020 \b\017\030\031\030)Tj 0 Tw (-)Tj 0.52 Tw T* [(\020\017\004\036\f\022\024\020\024 \024\021\007\036\035\036\027\017\016 \ )0.5(\205\206\207\211 \253\203\204\222\037 \020\036\n\026\021\024\035\024\020\ \017\017\273 )]TJ 0 Tw T* (\204\017\027\007\030\026\r\026 \217\024\f\f\017\017; ORCID: 0000-0003-3\ 677-0480)Tj 0.108 Tw 23.244 24.356 Td [(\203\024\r\017\022\024\r )0.5(\200\016\004\036\f\035\026\r )0.6(\202\035\036\022\f\026\027\007\030\024\r\017\004)]TJ /Span<>> BDC ( )Tj EMC 14.69 0 Td [(\227 )0.5(\022.\n.\027., )0.6(\026\r\036\007\031)]TJ 0 Tw (-)Tj 0.331 Tw -14.69 -1.218 Td [(\033\013\017\005 )0.5(\027\026\031\004\027\024-\022\035\017\027\017\004\036\f\022\017\n )0.5(\024\021\007\036\035\036\027\017\036\n )0.6(\026\027\036\f\021\036\017\024)]TJ 0 Tw (-)Tj 0.059 Tw T* (\035\024\020\017\017, \030\036\026\027\017\n\026\021\024\035\024\020\017\ \017 \017)Tj /Span<>> BDC ( )Tj EMC (\017\027\021\036\027\f\017\r\027\024\005 \021\036\030\026\023\017\017 \205\ \206\207\211 )Tj 0.512 Tw T* [(\253\203\204\222\037 \020\036\n\026\021\024\035\024\020\017\017\273 )0.5(\204\017\027\007\030\026\r\026 \217\024\f\f\017\017; ORCID: )]TJ 0 Tw T* (0000-0002-8776-6724)Tj 0.073 Tw T* (\212\026\027\017\001\016\027 \025\026\030\036\027 \222\f\n\026\017\035\024\ \r\017\004)Tj /Span<>> BDC ( )Tj EMC (\227 \007\024\022\021\024\030 \n\036\007\017\006\017\027\f\022\017\b )Tj 0.191 Tw 0 -1.218 TD [(\027\026\031\022, \026\r\036\007\031\033\013\017\005 \b\017\030\031\030\ \020\017\004\036\f\022\017\n )0.5(\024\021\007\036\035\036\027\017\036\n \205\206\207\211 )]TJ 0.512 Tw 0 -1.218 TD [(\253\203\204\222\037 \020\036\n\026\021\024\035\024\020\017\017\273 )0.5(\204\017\027\007\030\026\r\026 \217\024\f\f\017\017; ORCID: )]TJ 0 Tw T* (0000-0001-6732-8286)Tj 0.384 Tw T* (\215\026\030\024\r\017\004\027\017\022\024\r\026 \213\035\036\027\026 \203\ \017\022\024\035\026\036\r\027\026)Tj /Span<>> BDC ( )Tj EMC (\227 \007\024\022\021\024\030 \n\036)Tj 0 Tw (-)Tj 0.855 Tw T* (\007\017\006\017\027\f\022\017\b \027\026\031\022, \020\036\027\036\030\026\ \035\034\027\t\005 \007\017\030\036\022\021\024\030 \205\206\207\211 )Tj 0.773 Tw T* (\253\203\026\006\017\024\027\026\035\034\027\t\005 \n\036\007\017\006\017\ \027\f\022\017\005 \017\f\f\035\036\007\024\r\026\021\036\035\034\f\022\017\ \005 )Tj 0.143 Tw 0 -1.218 TD (\006\036\027\021\030 \020\036\n\026\021\024\035\024\020\017\017\273 \204\ \017\027\017\f\021\036\030\f\021\r\026 \007\030\026\r\024\024\b\030\026\ \027\036\027\017\016 )Tj -0.047 Tw 0 -1.218 TD (\217\024\f\f\017\005\f\022\024\005 \205\036\007\036\030\026\006\017\017;\ ORCID: 0000-0001-6177-3566)Tj /T1_1 1 Tf 0.023 Tw 0 -2.436 TD (INFORMATION ABOUT THE AUTHORS \(ORCID\))Tj /T1_2 1 Tf 0 Tw 0 -1.218 TD [(Sve)-12(tl)-15.9(ana V. S)-16(ht)-10(yr)-23.9(kov)-15(a)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0002-4272-8433)Tj T* [(Ol)16(ga A. S)-15.9(obolev)-15(a)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0001-9879-2664)Tj T* [(Kir)-37(ill R. Sabir)-31.9(ov)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0003-3677-0480)Tj T* [(V)-16(y)22(a)-17(chesl)-15.9(av A. N)-14(ov)-15.9(ikov)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0002-8776-6724)Tj T* [(K)-16(ar)-24(en I. Nt)15.1(anishy)22(an)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0001-6732-8286)Tj T* [(Elena N. P)40.1(ar)-32(ov)-16(ichnikov)-14.9(a)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0001-6177-3566)Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 42.5896 432.5579 Tm [(\r\031\024\034\033)48(\026)45(\024)-10(\223\033)48(\026)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf 0 Tc 0.34 Tw 8 0 0 8 42.5197 419.7232 Tm (1.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Har)-10(sh)]TJ /Span<>> BDC ( )Tj EMC (G, Guillem)Tj /Span<>> BDC ( )Tj EMC [(JG, S)15(tuar)-22(t)]TJ /Span<>> BDC ( )Tj EMC [(HQ, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Anor)-24(ec)-16(t)15(al Disease in )]TJ 0.015 Tc 0.557 Tw -1.296 -1.25 Td [(Neutr)-32.2(openic L)34.8(euk)9.8(emic P)39.7(a)14.8(t)-32.2(ients. Oper)-33.2(a)14.7(t)-32.2(i)-16.3(ve vs. N)-14.2(onoper)-33.2(a)14.7(t)-32.2(i)-16.3(ve)15( )]TJ 0 Tc 0 Tw 0 -1.25 TD [(Mana)-17(gement. )]TJ /T1_3 1 Tf 0.023 Tw 5.707 0 Td [(Dis Colon R)21(ectum)]TJ /T1_2 1 Tf (. 1994;37:1095\2261099.)Tj 0.04 Tw -5.707 -1.25 Td (2.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(M)-24(or)-32(cos)]TJ /Span<>> BDC ( )Tj EMC 3.136 0 Td [(B, )0.5(Amar)-37(in)]TJ /Span<>> BDC ( )Tj EMC [(R, )0.5(A)-14(bu )0.5(Sba)]TJ /Span<>> BDC ( )Tj EMC 8.705 0 Td [(A, )0.5(e)-12(t)]TJ /Span<>> BDC ( )Tj EMC 2.115 0 Td [(al. )0.5(Contem)10(por)-32.9(ar)-24(y )0.5(mana)-17(gement )]TJ 0.186 Tw -15.253 -1.25 Td [(of )0.6(per)-37(ianal )0.5(condi)-23.9(t)-32(ions )0.6(in )0.5(febr)-36.9(ile )0.5(neutr)-31.9(openic )0.5(p)32(a)15(t)-32(ients. )]TJ /T1_3 1 Tf 23.326 0 Td [(Eur )0.6(J )0.5(Surg )]TJ 0 Tw -23.326 -1.25 Td (Oncol.)Tj /T1_2 1 Tf 0.023 Tw [( 2013;39\(4\):404\2267. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1016/j.ejso)Tj 0 0 0 1 k /GS1 gs 0.135 Tw T* (3.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (Chen)Tj /Span<>> BDC ( )Tj EMC (CY, Cheng)Tj /Span<>> BDC ( )Tj EMC (A, Huang)Tj /Span<>> BDC ( )Tj EMC [(S)-32(Y, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Cl)-31(inical and micr)-32(obiol)30(o)-16(gical )]TJ 0.164 Tw -1.296 -1.25 Td [(char)-33(a)-17(c)-15.9(ter)-37(ist)-32(ics of per)-37(ianal infec)-16(t)-32(ions in adul)56(t p)32(a)15(t)-31.9(ients wi)-24(t)-12.9(h a)-17(cute )]TJ 0 Tw T* [(leuk)10(emia. )]TJ /T1_3 1 Tf 0.007 Tw 4.147 0 Td (PLoS One.)Tj /T1_2 1 Tf [( 2013; 8\(4\). d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw [(10.1371/jour)-15(nal.pone.0060624)]TJ 0 0 0 1 k /GS1 gs ( )Tj 0.004 Tc -0.004 Tw -4.147 -1.25 Td [(ht)-29.6(tp://www.pl)30.4(osone.or)-31.6(ght)-29.6(tp://www.pubmedcentr)-32.6(al.)0.5(gov/t)17.5(o)-15.7(cr)-23.5(ende)0.5(r.)]TJ 0 Tc 0 Tw T* [(fcgi?jour)-14.9(nal=440)]TJ 0.13 Tw T* (4.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(S)-16(olma)-24(z)]TJ /Span<>> BDC ( )Tj EMC 3.227 0 Td [(S, )0.5(K)25(or)-21.9(ur)]TJ /Span<>> BDC ( )Tj EMC 3.536 0 Td [(A, )0.5(Ger)-23.9(ekl)-31(io\262l)35(u)]TJ /Span<>> BDC ( )Tj EMC 6.032 0 Td [(\307, )0.5(e)-12(t)]TJ /Span<>> BDC ( )Tj EMC 2.208 0 Td [(al. )0.6(Anor)-24(ec)-16(t)15(al )0.6(Com)10(pl)-31(ica)15(t)-32(ions )]TJ 0.152 Tw -16.299 -1.25 Td [(Dur)-37(ing Neutr)-32(openic P)30(er)-37(iod in P)40(a)15(t)-32(ients wi)-23.9(t)-13(h Hema)15(t)17(ol)30.1(o)-16(gic Diseases. )]TJ /T1_3 1 Tf 0.015 Tc 0.551 Tw T* [(Mediter)-16.1(r J Hematol Infect Dis)]TJ /T1_2 1 Tf [(. 2016 Mar 1;8\(1\):e2016019.)15( )]TJ 0 Tc 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.4084/MJHID.2016.019)Tj 0 0 0 1 k /GS1 gs 0.023 Tw [( eCollec)-16(t)-32(ion 2016.PMID: 26977278)]TJ -0.023 Tw -1.847 -1.25 Td (5.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (Chang)Tj /Span<>> BDC ( )Tj EMC 2.677 0 Td [(H, )0.6(K)25(uo )0.5(M-C, )0.6(T)40(ang )0.5(T-C, )0.6(e)-12(t)]TJ /Span<>> BDC ( )Tj EMC 9.434 0 Td [(al. )0.6(Cl)-31(inical )0.6(F)10(ea)15(tur)-24(es )0.6(and )0.5(R)13(ecur)-24(r)-23.9(ence )]TJ -0.008 Tw -13.407 -1.25 Td [(P)40(a)15(t)-30(ter)-14.9(n of P)30(er)-37(ianal A)-14(bscess in P)40(a)15(t)-32(ients wi)-24(t)-13(h A)-25(cute M)16(yel)30(oid L)35(euk)10(emia. )]TJ /T1_3 1 Tf 0.023 Tw T* (Acta Haematologica.)Tj /T1_2 1 Tf [( 2017, 138\(1\): 10\22613. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1159/000475589)Tj 0 0 0 1 k /GS1 gs 0.014 Tc 0.5 Tw T* (6.)Tj /Span<>> BDC ( )Tj EMC 1.337 0 Td (\234\021\t\030\022\024\r\026)Tj /Span<>> BDC ( )Tj EMC (\221.\200., \025\035\016\f\024\r\026)Tj /Span<>> BDC ( )Tj EMC (\206.\202., \025\026\030\026\020\033\035\016\027)Tj /Span<>> BDC ( )Tj EMC (\221.\217., \017)Tj /Span<>> BDC ( )Tj EMC [(\f\024\026\r\021.)14.1( )]TJ 0 Tc 0.239 Tw -1.337 -1.25 Td (\210\f\024\002\036\027\027\024\f\021\017 \023\036\030\017\026\027\026\035\ \034\027\t\b \017\027\235\036\022\006\017\024\027\027\t\b \024\f\035\024\ \032\027\036\027\017\005 \031)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\034)Tj 0 Tw (-)Tj 0.043 Tw T* (\027\t\b \f)Tj /Span<>> BDC ( )Tj EMC (\020\030\026\027\031\035\024\006\017\021\024\023\036\027\017\036\005 \017\ )Tj /Span<>> BDC ( )Tj EMC (\024\023\031\b\024\035\036\r\t\n\017 \026\002\024\035\036\r\026\027\017\ \016\n\017 \f\017\f\021\036\n\t )Tj 0 Tw T* (\022\030\024\r\017. )Tj /T1_3 1 Tf 3.067 0 Td (\222\n\023\n\033\032\n\013\024\n\023\n\202\025\002.)Tj /T1_2 1 Tf 0.083 Tw [( 2020;19\(4\):10\22621. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.33878/2073-)Tj -3.067 -1.25 Td (7556-2020-19-4-10-3)Tj 0 0 0 1 k /GS1 gs 0.012 Tc 0.45 Tw T* (7.)Tj /Span<>> BDC ( )Tj EMC 1.333 0 Td (\207\024\035\022\r\026\007\036)Tj /Span<>> BDC ( )Tj EMC (\224.\224., \213\020\024\030\022\017\027)Tj /Span<>> BDC ( )Tj EMC (\204.\202. \025\035\026\f\f\017\235\017\022\026\006\017\016 \017)Tj /Span<>> BDC ( )Tj EMC [(\035\036\004\036\027\017\036)12( )]TJ 0 Tc 0.304 Tw -1.333 -1.25 Td (\f\035\024\032\027\t\b \235\024\030\n \024\f\021\030\024\020\024 \023\026\ \030\026\023\030\024\022\021\017\021\026. \215\016\021\027\026\007\006\026\ \021\017\035\036\021\027\017\005 \024\023\t\021. )Tj /T1_3 1 Tf 0 Tw T* (\222\n\023\n\033\032\n\013\024\n\023\n\202\025\002.)Tj /T1_2 1 Tf 0.023 Tw ( 2012;2:13\25716.)Tj 0.008 Tc 0.35 Tw T* (8.)Tj /Span<>> BDC ( )Tj EMC 1.321 0 Td [(L)34.8(our)-24.2(eir)-32.2(o)]TJ /Span<>> BDC ( )Tj EMC [(RV, Bor)-32.2(ges)]TJ /Span<>> BDC ( )Tj EMC [(VP, T)44.8(om\351)]TJ /Span<>> BDC ( )Tj EMC [(AL, e)-12.3(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Anor)-24.2(ec)-16.2(t)14.8(al com)9.8(pl)-31.2(i)]TJ 0 Tc 0 Tw (-)Tj 0.011 Tc 0.423 Tw -1.321 -1.25 Td [(ca)14.6(t)-32.4(ions in p)31.6(a)14.6(t)-32.4(ients wi)-24.4(t)-13.4(h haema)14.6(t)16.6(ol)29.6(o)-16.4(gical mal)-31.4(ignanc)-24.4(ies. )]TJ /T1_3 1 Tf [(Eur J)11( )]TJ 0.397 Tw T* (Gastroenterol Hepatol. )Tj /T1_2 1 Tf [(2018 Jul;30\(7\):722\226726. d)-15.7(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs -0.011 Tw (10.1097/)Tj 0 Tc 0 Tw T* (MEG.0000000000001133)Tj 0 0 0 1 k /GS1 gs 0.106 Tw T* (9.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (\202\027\007\030\036\036\r)Tj /Span<>> BDC ( )Tj EMC (\202.\202., \212\036\n\034\016\027\024\r)Tj /Span<>> BDC ( )Tj EMC (\202.\200. \204\036\021\024\007 \020\017\007\030\024\017\n\023\031\035\034\ \f\027\024\005 \f\026\027\026\006\017\017 )Tj 0.037 Tw -1.296 -1.25 Td (\r)Tj /Span<>> BDC ( )Tj EMC (\022\024\n\023\035\036\022\f\027\024\n \035\036\004\036\027\017\017 \024\ \f\021\030\024\020\024 \023\026\030\026\023\030\024\022\021\017\021\026.\ )Tj /T1_3 1 Tf (\207\025\t\024\031\003\021\020\017 \026\021\026\023\025\016 )Tj 0.023 Tw T* (\025)Tj /Span<>> BDC ( )Tj EMC (\205\033\032\026\027\023\031\021\025\031 \027)Tj /Span<>> BDC ( )Tj EMC (\005\025\n\003\031\030\025\203\025\021\t\013\025\004 \t\025\t\024\031\003\ \026\004.)Tj /T1_2 1 Tf ( 2014;13\(3\):677\226683.)Tj 0.161 Tw T* (10.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Chen)Tj /Span<>> BDC ( )Tj EMC [(SQ, L)-32(iu)]TJ /Span<>> BDC ( )Tj EMC (WC, Zhang)Tj /Span<>> BDC ( )Tj EMC [(ZZ, e)-11.9(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Appl)-31(ica)15(t)-32(ion of cl)30(osed nega)]TJ 0 Tw (-)Tj 0.286 Tw -1.796 -1.25 Td [(t)-32(i)-16(ve p)25(r)-23.9(essur)-24(e ir)-24(r)-36.9(iga)15(t)-32(ion and suc)-16(t)-32(ion dev)-15.9(ice in t)-13(he tr)-24(ea)15(tment of )]TJ 0.082 Tw 29.055 42.5 Td [(high per)-37(ianal abscess. )]TJ /T1_3 1 Tf [(Zhonghua W)30.1(ei Chang W)30(ai K)22(e Za Zhi.)]TJ /T1_2 1 Tf [( 2019 Ap)25(r )]TJ 0.02 Tw T* [(25;22\(4\):364\226369. )0.5(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw 9.795 0 Td (10.3760/cma.j.issn.1671-0274.2019.04.009)Tj 0 0 0 1 k /GS1 gs 0.274 Tw -9.795 -1.25 Td (11.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (\215\026\030\024\r\017\004\027\017\022\024\r\026)Tj /Span<>> BDC ( )Tj EMC (\213.\203., \230\030\024\017\006\022\026\016)Tj /Span<>> BDC ( )Tj EMC (\200.\200., \025\035\016\f\024\r\026)Tj /Span<>> BDC ( )Tj EMC (\206.\202., \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. )Tj 0.308 Tw -1.796 -1.25 Td [(\214\036\004\036\027\017\036 )0.5(\002\024\035\034\027\t\b )0.6(\024\f\021\030\t\n\017 )0.5(\n\017\036\035\024\017\007\027\t\n\017 )0.5(\035\036\005\022\024\026\n\017 )0.6(\023\024)]TJ /Span<>> BDC ( )Tj EMC 24.903 0 Td (\023\030\024\021\024)Tj 0 Tw (-)Tj 0.012 Tc 0.428 Tw -24.903 -1.25 Td [(\022\024\035)0.5(\031 \030\024)0.5(\f\f\017)0.5(\005\f\022\024)0.5(\020\024 \n)0.5(\027\024\020\024)0.5(\006\036\027\021)0.5(\030\024\r)0.5(\024\020\024 \030)0.5(\026\027\007)0.5(\024\n\017)0.5(\017\030\024)0.5(\r\026\027\027)0.5(\024\020\024)0.5( \017\f)]TJ 0 Tc 0 Tw (-)Tj 0.003 Tc 0.349 Tw T* [(\f\035\036\007\024\r\026\027\017\016 \210\204\214-01.10: \030\036\031\035\ \034\021\026\021\t \022\024\024\030\007\017\027\026\006\017\024\027\027\024\ \020\024 \006\036\027\021\030\026.)3.1( )]TJ /T1_3 1 Tf 0 Tc 0.023 Tw T* (\220\031\032\026\033\031\027\024\025\006\031\t\013\025\017 \026\032\004\025\ \027.)Tj /T1_2 1 Tf ( 2014;86\(7\):14\22623.)Tj 0.18 Tw T* (12.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Ok)10(en)]TJ /Span<>> BDC ( )Tj EMC [(MM, Cr)-24(eech)]TJ /Span<>> BDC ( )Tj EMC [(RH, T)45(or)-16(me)-11(y)]TJ /Span<>> BDC ( )Tj EMC [(DC, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. T)45(o)14(xic)-23.9(i)-24(t)-10(y and r)-24(esponse )]TJ 0.032 Tw -1.796 -1.25 Td [(cr)-37(i)-23.9(ter)-37(ia of t)-13(he Easter)-15(n Co)-16(oper)-33(a)15(t)-32(i)-15.9(ve Oncol)30(o)-16(g)16(y G)20(r)-31.9(oup. )]TJ /T1_3 1 Tf (Am J Clin Oncol.)Tj /T1_2 1 Tf 0 Tw ( )Tj T* (1982;5\(6\):649\22655.)Tj 0.187 Tw T* (13.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Hal)-31(il)30.1(o)-16(gl)35(u)]TJ /Span<>> BDC ( )Tj EMC (N, Gulpinar)Tj /Span<>> BDC ( )Tj EMC [(B, Ozk)-17(avukcu)]TJ /Span<>> BDC ( )Tj EMC [(E, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. T)40(ypical MR ima)-16.9(g)]TJ 0 Tw (-)Tj 0.256 Tw -1.796 -1.25 Td [(ing f)-28(indings of per)-37(ianal infec)-15.9(t)-32(ions in p)32(a)15(t)-32(ients wi)-24(t)-13(h hema)15(t)17.1(ol)30(o)-16(gic )]TJ 0 Tw T* [(mal)-31(ignanc)-23.9(ies. )]TJ /T1_3 1 Tf 0.137 Tw 6.016 0 Td [(Eur J R)20(adiol)]TJ /T1_2 1 Tf [(. 2017 A)10(ug;93:284\226288. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1016/j.)Tj -6.016 -1.25 Td [(ejr)-33(ad.2017.05.046)]TJ 0 0 0 1 k /GS1 gs 0.023 Tw ( Epub 2017 Jun 3)Tj 0.061 Tw T* (14.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Pl)35(umb)]TJ /Span<>> BDC ( )Tj EMC [(AA, Hall)-30.9(igan)]TJ /Span<>> BDC ( )Tj EMC [(S, Bha)15(tna)-17(gar)]TJ /Span<>> BDC ( )Tj EMC [(G, T)40(a)15(yl)30(or)]TJ /Span<>> BDC ( )Tj EMC [(SA. P)30(er)-37(ianal Sepsis in )]TJ 0.103 Tw -1.796 -1.25 Td [(Hema)15(t)17(ol)30(o)-16(gic Mal)-30.9(ignancy: MR Ima)-17(ging Appear)-33(ances and Dist)-32(inc)-15.9(t)-32(ion )]TJ 0.009 Tc 0.349 Tw T* [(fr)-31.7(om Cr)-23.7(ypt)17.2(o)-15.7(gl)-15.8(andul)-15.8(ar Infec)-15.8(t)-31.8(ion in Immuno)-15.8(com)10.2(pe)-11.8(tent P)40.2(a)15.2(t)-31.7(ients.)9( )]TJ /T1_3 1 Tf 0 Tc 0 Tw T* [(R)20(adiology)]TJ /T1_2 1 Tf 0.167 Tw [(. 2015 Jul;276\(1\):147\22655. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw [(10.1148/r)-33(adiol.15141662)]TJ 0 0 0 1 k /GS1 gs ( )Tj 0.023 Tw T* (Epub 2015 Mar 10.PMID: 25759970)Tj 0.128 Tw T* (15.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Mar)-24(k)-10(s)]TJ /Span<>> BDC ( )Tj EMC 2.676 0 Td (G, Chase)Tj /Span<>> BDC ( )Tj EMC [(WV, Mer)-32(v)-15.9(ine)]TJ /Span<>> BDC ( )Tj EMC [(T.B. T)47(he f)16(a)15(t)15(al po)17(tent)-32(ial of f)-28(istul)-15.9(a-)]TJ 0.002 Tc 0.35 Tw -4.472 -1.25 Td [(in-ano wi)-24.1(t)-13.1(h )0.5(abscess: anal)34.9(y)-13.1(sis of 11 dea)14.9(t)-13.1(hs. )]TJ /T1_3 1 Tf [(Dis Colon R)20.9(ectum)]TJ /T1_2 1 Tf 0 Tc 0 Tw (. )Tj T* (1973;16:224\22630.)Tj 0.008 Tc 0.35 Tw T* (16.)Tj /Span<>> BDC ( )Tj EMC 1.829 0 Td [(V)28.8(o)-16.1(gel)]TJ /Span<>> BDC ( )Tj EMC (JD, Johnson)Tj /Span<>> BDC ( )Tj EMC [(EK, M)-24.2(or)-24.2(r)-37.1(is)]TJ /Span<>> BDC ( )Tj EMC [(AM, e)-12.2(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Cl)-31.2(inical P)34.8(r)-33.1(a)-17.2(c)-16.1(t)-32.2(ice)8( )]TJ 0 Tc 0.072 Tw -1.829 -1.25 Td [(Guidel)-30.9(ine for t)-12.9(he Mana)-17(gement of Anor)-24(ec)-16(t)15(al A)-14(bscess, F)-19(istul)-15.9(a-in-Ano, )]TJ 0.267 Tw T* [(and R)13(ec)-16(t)17(ov)-15(a)-16.9(ginal F)-19(istul)-16(a. )]TJ /T1_3 1 Tf [(Dis Colon R)21(ectum)]TJ /T1_2 1 Tf (. 2016 ;59\(12\):1117\226)Tj 0.023 Tw T* (1133. PMID: 27824697)Tj 0.016 Tc 0.564 Tw T* [(1)0.5(7)0.6(.)]TJ /Span<>> BDC 1.342 0 Td ( )Tj EMC 0.515 0 Td [(\204)0.5(\031)0.6(\007)0.5(\030)0.6(\024)0.5(\r)]TJ /Span<>> BDC 3.176 0 Td ( )Tj EMC [(\202)0.6(.)0.5(\202)0.6(.)0.5(,)0.6( \210)0.5(\n)0.6(\026)0.5(\030)0.6(\024)0.5(\r)0.5(\026)]TJ /Span<>> BDC 7.226 0 Td ( )Tj EMC [(\204)0.6(.)0.5(\204)0.6(.)0.5(,)0.6( \205)0.5(\024)0.6(\n)0.5(\036)0.6(\027)0.5(\022)0.5(\024)]TJ /Span<>> BDC 7.567 0 Td ( )Tj EMC [(\210)0.6(.)0.5(\236)0.6(.)0.5(,)0.6( \017)]TJ /Span<>> BDC 4.37 0 Td ( )Tj EMC [(\f)0.6(\024)0.5(\026)0.5(\r)0.6(\021)0.5(.)16.1( )]TJ 0 Tc 0.077 Tw -24.197 -1.25 Td (\216\017\030\031\030\020\017\004\036\f\022\024\036 \035\036\004\036\027\017\ \036 \030\036\022\021\024\r\026\020\017\027\026\035\034\027\t\b \f\r\017\ \013\036\005 \030\026\f\013\036\023\035\036\027\027\t\n )Tj -0.006 Tw T* [(\r\035\026\020\026\035\017\013\027\024-\023\030\016\n\024\022\017\001\036\ \004\027\t\n )0.5(\035\024\f\022\031\021\024\n. )]TJ /T1_3 1 Tf [(\206\025\032\205\032\202\025\002. )0.5(\241\205\032\021\026\023 \025\003. \217.\215. )]TJ 0 Tw T* (\025\032\n\202\n\027\026.)Tj /T1_2 1 Tf 0.023 Tw [( 2021;07:5\22611. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw [(10.17116/hir)-22(ur)-32(gia20210715)]TJ 0 0 0 1 k /GS1 gs 0.007 Tc 0.349 Tw T* (18.)Tj /Span<>> BDC ( )Tj EMC 1.823 0 Td [(S)-15.8(hal)-15.8(ab)12.1(y)]TJ /Span<>> BDC ( )Tj EMC (M, Emile)Tj /Span<>> BDC ( )Tj EMC [(S, Elfek)-15.9(i)]TJ /Span<>> BDC ( )Tj EMC [(H, e)-11.8(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Sy)-12.8(stema)15.1(t)-31.8(ic r)-23.7(ev)-15.8(iew of)7( )]TJ 0.006 Tc -1.823 -1.25 Td [(end)-15.9(ol)35(uminal v)-14.9(a)-17(cuum-assisted t)-13(her)-33(apy as sal)30(v)-14.9(a)-16.9(ge tr)-23.9(ea)15(tment for)6( )]TJ 0 Tc 0.138 Tw T* [(r)-24(ec)-15.9(t)15(al anast)17(omo)17(t)-32(ic leak)-17(a)-17(ge. )]TJ /T1_3 1 Tf (BJS Open)Tj /T1_2 1 Tf (. 2018 Dec 26;3\(2\):153\226160. )Tj 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1002/bjs5.50124)Tj 0 0 0 1 k /GS1 gs 0.023 Tw ( PMID: 30957061; PMCID: PMC6433422.)Tj 0.164 Tw -1.847 -1.25 Td (19.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(New)-24(t)17(on)]TJ /Span<>> BDC ( )Tj EMC [(K, P)30(ear)-31.9(ce)]TJ /Span<>> BDC ( )Tj EMC [(L, Br)-37(iggs)]TJ /Span<>> BDC ( )Tj EMC [(M, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. P)10(ost)17(oper)-33(a)15(t)-31.9(i)-16(ve P)40(a)-17(ck)-16(ing of )]TJ 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 0 Tw 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\033\030\031\030\213\b)-20.9(\035\231\213\233\t \021\032)50(\b)42(\032\231\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj /T1_5 1 Tf 25 0 0 25 505.552 56.0378 Tm (127)Tj ET endstream endobj 1136 0 obj <>/Border[0 0 0]/H/N/Rect[142.686 377.019 190.277 367.563]/Subtype/Link/Type/Annot>> endobj 1137 0 obj <>/Border[0 0 0]/H/N/Rect[162.127 347.019 263.622 337.563]/Subtype/Link/Type/Annot>> endobj 1138 0 obj <>/Border[0 0 0]/H/N/Rect[57.2978 287.019 141.217 277.723]/Subtype/Link/Type/Annot>> endobj 1139 0 obj <>/Border[0 0 0]/H/N/Rect[195.348 257.019 261.259 247.563]/Subtype/Link/Type/Annot>> endobj 1140 0 obj <>/Border[0 0 0]/H/N/Rect[210.894 217.019 263.622 207.563]/Subtype/Link/Type/Annot>> endobj 1141 0 obj <>/Border[0 0 0]/H/N/Rect[42.5197 207.019 112.599 197.723]/Subtype/Link/Type/Annot>> endobj 1142 0 obj <>/Border[0 0 0]/H/N/Rect[233.112 147.019 263.622 137.563]/Subtype/Link/Type/Annot>> endobj 1143 0 obj <>/Border[0 0 0]/H/N/Rect[42.5197 137.019 122.383 127.723]/Subtype/Link/Type/Annot>> endobj 1144 0 obj <>/Border[0 0 0]/H/N/Rect[353.32 417.019 496.063 407.723]/Subtype/Link/Type/Annot>> endobj 1145 0 obj <>/Border[0 0 0]/H/N/Rect[461.551 307.019 496.063 297.563]/Subtype/Link/Type/Annot>> endobj 1146 0 obj <>/Border[0 0 0]/H/N/Rect[274.961 297.019 334.52 287.723]/Subtype/Link/Type/Annot>> endobj 1147 0 obj <>/Border[0 0 0]/H/N/Rect[412.992 257.019 496.063 247.563]/Subtype/Link/Type/Annot>> endobj 1148 0 obj <>/Border[0 0 0]/H/N/Rect[374.654 137.019 466.502 127.563]/Subtype/Link/Type/Annot>> endobj 1149 0 obj <>/Border[0 0 0]/H/N/Rect[289.739 97.0193 355.362 87.7232]/Subtype/Link/Type/Annot>> endobj 1163 0 obj <> endobj 1162 0 obj <> endobj 1161 0 obj <> endobj 1160 0 obj <> endobj 1159 0 obj <> endobj 1158 0 obj <> endobj 1157 0 obj <> endobj 1156 0 obj <> endobj 1155 0 obj <> endobj 1154 0 obj <> endobj 1153 0 obj <> endobj 1152 0 obj <> endobj 1151 0 obj <> endobj 1150 0 obj <> endobj 1082 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.288 Tw 10 0 0 10 70.8661 724.8299 Tm [(\022\035\017\027\017\022\024-\035\026\002\024\030\026\021\024\030\027\026\ \016 )0.5(\022\026\030\021\017\027\026 \f\036\023\f\017\f\026 \017)]TJ /Span<>> BDC ( )Tj EMC (\021\016\032\036\035\024\036 )Tj 0 Tw 0 -1.218 TD (\f\024\f\021\024\016\027\017\036 \023\026\006\017\036\027\021\026.)Tj 0.23 Tw T* (\200\026\032\027\t\n \030\036\031\035\034\021\026\021\024\n \027\026\f\021\ \024\016\013\036\020\024 \017\f\f\035\036\007\024\r\026\027\017\016 \016\ \r)Tj 0 Tw (-)Tj 0.059 Tw T* (\035\016\036\021\f\016 \007\036\n\024\027\f\021\030\026\006\017\016 \r\024\ \n\024\032\027\024\f\021\017 \017)Tj /Span<>> BDC ( )Tj EMC (\220\235\235\036\022\021\017\r\027\024\f\021\017 )Tj 0.262 Tw T* (\023\030\017\n\036\027\036\027\017\016 \r\026\022\031\031\n-\021\036\030\ \026\023\017\017 \007\035\016 \035\036\004\036\027\017\016 \023\026\030\026\ \030\036\022)Tj 0 Tw (-)Tj 0.064 Tw T* (\021\026\035\034\027\t\b \030\026\027 \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\027\036\005\021\030\024\023\036\027\017\036\005. \212\035\016 \f\026\n\024\ )Tj 0 Tw (-)Tj -0.028 Tw 0 -1.218 TD (\f\021\024\016\021\036\035\034\027\024\020\024 \026\032\017\r\035\036\027\ \017\016 \030\026\027\t \007\024\035\032\027\t \023\030\024\005\021\017 \ \220\021\026\023\t )Tj 0.34 Tw 0 -1.218 TD (\024\004\017\013\036\027\017\016 \024\021 \027\036\032\017\027\036\f\023\ \024\f\024\002\027\t\b \021\022\026\027\036\005 \017)Tj /Span<>> BDC ( )Tj EMC (\n\017\022\030\024)Tj 0 Tw (-)Tj 0.139 Tw T* (\024\030\020\026\027\017\n\024\r, \030\036\020\036\027\036\030\026\006\017\ \017 \004\036\030\036 \024\002\030\026\024\r\026\027\017\036 \020\030\026\ \027\031)Tj 0 Tw (-)Tj 0.174 Tw T* [(\035\016\006\017\024\027\027\024\005 )0.6(\021\022\026\027\017 )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC 8.502 0 Td [(\023\024\f\035\036\007\031\033\013\036\005 )0.5(\036\036 )0.5(\220\023\017\021\036\035\017\026\006\017\036\005 )]TJ 0.186 Tw -8.502 -1.218 Td (\023\024)Tj /Span<>> BDC ( )Tj EMC (\f\030\036\007\f\021\r\024\n \n\017\020\030\026\006\017\017 \220\023\017\ \021\036\035\017\016 \f)Tj /Span<>> BDC ( )Tj EMC (\022\030\026\036\r \030\026\027\036\r\024\020\024 )Tj 0.123 Tw T* (\007\036\235\036\022\021\026. \200\f\036 \220\021\017 \023\030\024\006\036\ \f\f\t \026\r\017\f\016\021 \024\021 \027\026\035\017\004\017\016 \020\030\ \026)Tj 0 Tw (-)Tj 0.098 Tw 0 -1.218 TD (\027\031\035\024\006\017\021\024\r. \215\024\220\021\024\n\031 \007\026\032\ \036 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\007\024\f\021\017\032\036\027\017\017 \022\024\027\021\030\024\035\016 \ )Tj 0.138 Tw 0 -1.218 TD (\027\026\007 \017\027\235\036\022\006\017\024\027\027\t\n \023\030\024\006\ \036\f\f\024\n \030\036\023\026\030\026\006\017\016 \030\026\027 \031)Tj /Span<>> BDC ( )Tj EMC (\023\026)Tj 0 Tw (-)Tj 0.148 Tw 0 -1.218 TD (\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\027\036\005\021\030\024\023\036\027\017\036\005 \016\r\035\016\036\021\f\ \016 \f\035\024\032\027\024\005 \023\030\024\002\035\036)Tj 0 Tw (-)Tj 0.094 Tw T* (\n\024\005. \210\021\f\031\021\f\021\r\017\036 \002\026\030\034\036\030\027\ \024\005 \235\031\027\022\006\017\017 \020\030\026\027\031\035\016\006\017\ \005 \016\r)Tj 0 Tw (-)Tj 0.062 Tw T* (\035\016\035\024\f\034 \023\030\017\004\017\027\024\005 \007\035\017\021\ \036\035\034\027\t\b \023\036\030\017\024\007\024\r \020\017\023\036\030\ \021\036\030\n\017\017 )Tj 0.343 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\023\024\f\035\036\024\023\036\030\026\006\017\024\027\027\024\n \023\036\ \030\017\024\007\036. \200)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\017\b \031\f\035\024\r\017\016\b )Tj 0.057 Tw T* (\f\024\022\030\026\013\036\027\017\036 \023\035\024\013\026\007\017 \030\ \026\027\036\r\024\005 \023\024\r\036\030\b\027\024\f\021\017 \016\r\035\ \016\036\021\f\016 )Tj 0.204 Tw T* (\r\026\032\027\036\005\001\017\n \235\026\022\021\024\030\024\n \022\031\ \023\017\030\024\r\026\027\017\016 \017\027\235\036\022\006\017\024\027\027\ \024\020\024 )Tj 0 Tw T* (\023\030\024\006\036\f\f\026.)Tj 0.012 Tc 0.311 Tw T* (\204\036\021\024\007 \r\024\007\036\005\f\021\r\017\016 \027\026)Tj /Span<>> BDC ( )Tj EMC (\030\026\027\031 \024\021\030\017\006\026\021\036\035\034\027\024\020\024\ \007\026\r)Tj 0 Tc 0 Tw (-)Tj 0.012 Tc 0.486 Tw T* [(\035\036\027\017\016 \023\024\r\024\035\016\036\021 \031\f\022\024\030\017\ \021\034 \023\030\024\006\036\f\f\t \030\036\023\026\030\026\006\017\017\ )12( )]TJ 0.026 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\031\f\023\036\001\027\024 \035\036\004\017\021\034 \030\026\027\t, \022\ \024\021\024\030\t\036 \027\036\r\024\n\024\032\027\024 \r\t\035\036)Tj 0 Tc 0 Tw (-)Tj 0.012 Tc 0.119 Tw T* [(\004\017\021\034 \007\030\031\020\017\n\017 \n\036\021\024\007\026\n\017\ . \210\f\027\024\r\027\t\n \023\030\036\017\n\031\013\036\f\021\r\024\n)12( )]TJ 0.611 Tw T* [(\023\030\017\n\036\027\036\027\017\016 )0.5(\024\021\030\017\006\026\021\036\035\034\027\024\020\024 )0.5(\007\026\r\035\036\027\017\016 \016\r\035\016\036\021\f\016)11.9( )]TJ 0.308 Tw T* (\024\002\036\f\023\036\004\036\027\017\036 \023\024\f\021\024\016\027\027\ \024\020\024 \007\030\036\027\017\030\024\r\026\027\017\016 \220\022\f\f\ \031\007\026)Tj 0 Tc 0 Tw (-)Tj 0.012 Tc 0.543 Tw T* [(\021\026, \031\n\036\027\034\001\036\027\017\036 \002\026\022\021\036\030\ \017\026\035\034\027\024\005 \024\002\f\036\n\036\027\036\027\027\024\f\021\ \017,)12( )]TJ 0.104 Tw T* (\031\n\036\027\034\001\036\027\017\016 \023\035\024\013\026\007\017 \030\ \026\027\036\r\024\020\024 \035\024\032\026 \017)Tj /Span<>> BDC ( )Tj EMC [(\f\021\017\n\031\035\016\006\017\016)12( )]TJ 0.345 Tw T* (\030\036\023\026\030\026\021\017\r\027\t\b \023\030\024\006\036\f\f\024\r\ . \214\024\022\026\035\034\027\024\036 \024\021\030\017\006\026\021\036\035\ \034)Tj 0 Tc 0 Tw (-)Tj 0.012 Tc 0.066 Tw T* (\027\024\036 \007\026\r\035\036\027\017\036 \017)Tj /Span<>> BDC ( )Tj EMC (\n\017\022\030\024\007\036\235\024\030\n\026\006\017\016 \021\022\026\027\ \036\005 \f\021\017\n\031\035\017)Tj 0 Tc 0 Tw (-)Tj 0.012 Tc -0.032 Tw T* [(\030\031\036\021 \026\027\020\017\024\020\036\027\036, \023\030\024\035\ \017\235\036\030\026\006\017\033 \022\035\036\021\024\022, \027\036\005\030\ \024\020\036\027\036,)11.9( )]TJ 0.355 Tw T* (\235\024\030\n\017\030\024\r\026\027\017\036 \020\030\026\027\031\035\016\ \006\017\024\027\027\024\005 \021\022\026\027\017 \017)Tj /Span<>> BDC ( )Tj EMC [(\002\t\f\021\030\024\036)12( )]TJ 0.022 Tw T* (\f\024\022\030\026\013\036\027\017\036 \030\026\n\036\030\024\r \030\026\ \027\036\r\024\020\024 \035\024\032\026 [18]. \200)Tj /Span<>> BDC ( )Tj EMC (\027\026\f\021\024)Tj 0 Tc 0 Tw (-)Tj 0.012 Tc 0.086 Tw T* (\016\013\036\n \017\f\f\035\036\007\024\r\026\027\017\017 \027\026)Tj /Span<>> BDC ( )Tj EMC [(\022\035\017\027\017\004\036\f\022\024\n \023\030\017\n\036\030\036 \002\ \t\035\024)12( )]TJ 0.393 Tw T* [(\023\030\024\007\036\n\024\027\f\021\030\017\030\024\r\026\027\024 \021\036\ \004\036\027\017\036 \030\026\027\036\r\024\020\024 \023\030\024\006\036\ \f\f\026)12( )]TJ 0.323 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC (\235\024\027\036 \023\024\f\021\024\016\027\027\024\005 \235\024\030\n\t\ \027\036\005\021\030\024\023\036\027\017\017. \200)Tj /Span<>> BDC ( )Tj EMC (\024\021)Tj 0 Tc 0 Tw (-)Tj 0.012 Tc 0.517 Tw T* [(\f\031\021\f\021\r\017\036 \035\036\004\036\027\017\016 \024\002\001\017\ \030\027\026\016 \023\024\f\035\036\024\023\036\030\026\006\017\024\027\027\ \026\016)12( )]TJ 0.048 Tw T* (\030\026\027\026 \f\031\013\036\f\021\r\024\r\026\035\026 \002\024\035\036\ \036 \007\r\031\b \n\036\f\016\006\036\r, \031\r\036\035\017\004\017\r\026\ )Tj 0 Tc 0 Tw (-)Tj 0.012 Tc 0.141 Tw T* (\016\f\034 \r)Tj /Span<>> BDC ( )Tj EMC (\030\026\n\036\030\036, \r\024\r\035\036\022\026\016 \r)Tj /Span<>> BDC ( )Tj EMC [(\017\027\235\036\022\006\017\024\027\027\t\005 \023\030\024\006\036\f\f)12( )]TJ 0.559 Tw T* [(\017\f\b\024\007\027\024 \017\027\021\026\022\021\027\t\036 \022\035\036\ \021\004\026\021\024\004\027\t\036 \023\030\024\f\021\030\026\027\f\021\r\ \026.)12( )]TJ 0.334 Tw T* (\203\026\030\016\007\031 \f)Tj /Span<>> BDC ( )Tj EMC (\b\017\030\031\030\020\017\004\036\f\022\024\005 \f\026\027\026\006\017\036\ \005 \017)Tj /Span<>> BDC ( )Tj EMC [(\007\035\017\021\036\035\034\027\024\005)12( )]TJ 0.249 Tw T* (\026\027\021\017\002\026\022\021\036\030\017\026\035\034\027\024\005 \021\ \036\030\026\023\017\036\005 \023\030\017\n\036\027\036\027\017\036 \r\026\ \022\031\031\n)Tj 0 Tc 0 Tw (-)Tj 0.012 Tc -0.049 Tw T* [(\027\024\005 \023\024\r\016\022\017 \023\024\r\024\035\017\035\024 \007\ \024\002\017\021\034\f\016 \023\036\030\036\b\024\007\026 \030\026\027\036\ \r\024\020\024)12( )]TJ 0.056 Tw T* (\023\030\024\006\036\f\f\026 \r)Tj /Span<>> BDC ( )Tj EMC (\235\026\031 \030\036\023\026\030\026\006\017\017. \230\026\022\032\036\ \r)Tj /Span<>> BDC ( )Tj EMC [(\017\f\f\035\036\007\024\r\026\027\017\017)11.9( )]TJ 0.364 Tw T* [(\023\024\022\026\026\027\026 \r\024\n\024\032\027\024\f\021\034 \r\t\023\ \024\035\027\036\027\017\016 \023\035\026\f\021\017\004\036\f\022\017\b)12( )]TJ 0.272 Tw T* (\024\023\036\030\026\006\017\005: \r)Tj /Span<>> BDC ( )Tj EMC (\024\007\027\024\n \f\035\031\004\026\036)Tj /Span<>> BDC ( )Tj EMC [(\227 \023\035\026\f\021\017\022\026 \030\026\027\036\r\024\020\024)12( )]TJ 0.241 Tw T* (\007\036\235\036\022\021\026 \022\024\032\027\t\n \035\024\f\022\031\021\ \024\n; \r)Tj /Span<>> BDC ( )Tj EMC (\007\030\031\020\024\n)Tj /Span<>> BDC ( )Tj EMC (\227 \030\036\022\021\024\r\026)Tj 0 Tc 0 Tw (-)Tj 0.012 Tc 0.243 Tw T* [(\020\017\027\026\035\034\027\024\005 \023\036\030\036\020\024\030\024\007\ \022\017 \030\026\f\013\036\023\035\036\027\027\t\n \f\035\017\017\f\021\ \t\n)12( )]TJ -0.012 Tw T* (\035\024\f\022\031\021\024\n.)Tj 0 Tc 0.254 Tw T* [(\224\235\235\036\022\021\017\r\027\024\f\021\034 )0.6(\023\030\017\n\036\027\036\027\017\016 )0.6(\024\021\030\017\006\026\021\036\035\034\027\024\020\024 )0.5(\007\026\r\035\036)]TJ 0 Tw (-)Tj 0.139 Tw T* (\027\017\016 \r)Tj /Span<>> BDC ( )Tj EMC (\035\036\004\036\027\017\036 \023\026\030\026\030\036\022\021\026\035\034\ \027\t\b \026\002\f\006\036\f\f\024\r \017)Tj /Span<>> BDC ( )Tj EMC (\f\r\017\013\036\005 )Tj 0.148 Tw T* (\023\030\036\007\f\021\026\r\035\036\027\026 \r)Tj /Span<>> BDC ( )Tj EMC (\030\016\007\036 \017\f\f\035\036\007\024\r\026\027\017\005 [19\22621]. \ \200)Tj /Span<>> BDC ( )Tj EMC (\030\026\027)Tj 0 Tw (-)Tj 0.284 Tw T* (\007\024\n\017\017\030\024\r\026\027\027\024\n \017\f\f\035\036\007\024\ \r\026\027\017\017 Chen S.Q. \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. )Tj 0.095 Tw 23.244 64.543 Td (2019)Tj /Span<>> BDC ( )Tj EMC (\020. \002\t\035\024 \023\024\022\026\026\027\024, \004\021\024 \023\030\ \017\n\036\027\036\027\017\036 \024\021\030\017\006\026\021\036\035\034)Tj 0 Tw (-)Tj 0.203 Tw T* (\027\024\020\024 \007\026\r\035\036\027\017\016 \023\024\r\024\035\016\036\ \021 \031\f\022\024\030\017\021\034 \026\032\017\r\035\036\027\017\036 \ \030\026)Tj 0 Tw (-)Tj 0.119 Tw T* (\027\036\r\024\020\024 \007\036\235\036\022\021\026, \031\n\036\027\034\001\ \017\021\034 \023\024\f\035\036\024\023\036\030\026\006\017\024\027\027\t\ \005 \002\024)Tj 0 Tw (-)Tj 0.11 Tw T* (\035\036\r\024\005 \f\017\027\007\030\024\n, \004\026\f\021\024\021\031 \ \030\036\006\017\007\017\r\024\r \017)Tj /Span<>> BDC ( )Tj EMC (\235\024\030\n\017\030\024\r\026\027\017\036 )Tj 0.061 Tw T* [(\f\r\017\013\036\005 [10]. \221\035\036\007\031\036\021 \024\021\n\036\021\ \017\021\034, \004\021\024 \023\030\017\n\036\027\036\027\017\036 V)37(A)16(C-)]TJ 0.138 Tw T* (\021\036\030\026\023\017\017 \r\024\n\024\032\027\024 \022\026\022 \031\ )Tj /Span<>> BDC ( )Tj EMC (\f\021\024\n\017\030\024\r\026\027\027\t\b \023\026\006\017\036\027\021\024\ \r, )Tj 0.151 Tw 0 -1.218 TD (\021\026\022 \017)Tj /Span<>> BDC ( )Tj EMC (\002\036 \027\026\035\024\032\036\027\017\016 \f\021\024\n\t, \f)Tj /Span<>> BDC ( )Tj EMC (\023\030\017\n\036\027\036\027\017\036\n \235\017\022\f\026)Tj 0 Tw (-)Tj 0.097 Tw 0 -1.218 TD (\021\024\030\024\r \f\021\024\n\026\007\020\036\017\r \017)Tj /Span<>> BDC ( )Tj EMC (\020\036\035\036\r\t\b \023\024\r\016\024\022 \027\026)Tj /Span<>> BDC ( )Tj EMC (\024\027\031 \026\027\031\f\026 )Tj 0 Tw T* ([22].)Tj 0.28 Tw T* (\210\021\f\031\021\f\021\r\017\036 \030\036\n\017\f\f\017\017 \020\036\n\ \024\002\035\026\f\021\024\026 \024\023\030\036\007\036\035\016\036\021\ \027\036)Tj 0 Tw (-)Tj 0.048 Tw T* [(\020\026\021\017\r\027\t\005 )0.6(\023\030\024\020\027\024 )0.5(\022\026\022 )0.5(\023\024)]TJ /Span<>> BDC ( )Tj EMC 10.669 0 Td [(\023\030\017\004\017\027\036 )0.6(\023\030\024\020\030\036\f\f\017\030\024\r\026\027\017\016 )]TJ 0.261 Tw -10.669 -1.218 Td (\024\023\031\b\024\035\036\r\024\020\024 \023\030\024\006\036\f\f\026, \021\ \026\022 \017)Tj /Span<>> BDC ( )Tj EMC (\017-\026 \027\036\r\024\n\024\032\027\024\f\021\017 )Tj 0.221 Tw 0 -1.218 TD (\r\024\f\f\021\026\027\024\r\017\021\034 \022\024\f\021\027\024\n\024\020\ \024\r\024\036 \022\030\024\r\036\021\r\024\030\036\027\017\036 \017)Tj /Span<>> BDC ( )Tj EMC (\017\n)Tj 0 Tw (-)Tj 0.097 Tw 0 -1.218 TD (\n\031\027\027\t\005 \f\021\026\021\031\f. \200\026\032\027\t\n \030\036\ \031\035\034\021\026\021\024\n \007\026\027\027\024\020\024 \017\f\f\035\ \036)Tj 0 Tw (-)Tj 0.235 Tw 0 -1.218 TD (\007\024\r\026\027\017\016 \016\r\035\016\036\021\f\016 \007\036\n\024\027\ \f\021\030\026\006\017\016 \r\024\n\024\032\027\024\f\021\017 \023\030\024\ )Tj 0 Tw (-)Tj 0.194 Tw T* (\r\036\007\036\027\017\016 \b\017\n\017\024\021\036\030\026\023\017\017 \ \023\026\006\017\036\027\021\026\n \f\024 \221\205\215. \211)Tj /Span<>> BDC ( )Tj EMC (\007\r\024\017\b )Tj 0.179 Tw T* (\023\026\006\017\036\027\021\024\r \023\024\f\035\036 \022\031\023\017\030\ \024\r\026\027\017\016 \017\027\235\036\022\006\017\024\027\027\024\020\024\ \023\030\024)Tj 0 Tw (-)Tj 0.088 Tw T* (\006\036\f\f\026, \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\027\026\035\017\004\017\017 \004\017\f\021\t\b \030\026\027 \002\t\035\017\ \023\030\024\r\036\007\036\027\t \017\027)Tj 0 Tw (-)Tj 0.068 Tw T* (\007\031\022\006\017\024\027\027\t\036 \022\031\030\f\t, \004\021\024 \023\ \024\r\024\035\017\035\024 \007\024\f\021\017\004\034 \030\036\n\017\f\f\ \017\017 )Tj 0 Tw T* (\020\036\n\024\002\035\026\f\021\024\026.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 303.3769 456.9138 Tm [(\020)21(\026\027\r\242\224\034\022\031\034)]TJ 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.002 Tc 0.381 Tw 10 0 0 10 303.3071 432.5578 Tm (\204\217\230 \024\030\020\026\027\024\r \n\026\035\024\020\024 \021\026\ \026)Tj /Span<>> BDC ( )Tj EMC [(\227 \n\036\021\024\007 \007\017\026\020\027\024\f\021\017\022\017,)2( )]TJ 0.55 Tw T* (\027\036\024\002\b\024\007\017\n\t\005 \007\035\016 \024\023\030\036\007\ \036\035\036\027\017\016 \024\002\255\036\n\026 \023\024\030\026\032\036\ )Tj 0 Tc 0 Tw (-)Tj 0.002 Tc 0.338 Tw T* [(\027\017\016 )0.5(\023\030\017)]TJ /Span<>> BDC ( )Tj EMC 4.179 0 Td [(\221\205\215 )0.5(\031)]TJ /Span<>> BDC ( )Tj EMC 3.3 0 Td [(\024\027\022\024\020\036\n\026\021\024\035\024\020\017\004\036\f\022\017\ \b )0.5(\023\026\006\017\036\027\021\024\r.)2( )]TJ 0.147 Tw -7.479 -1.218 Td (\217\026\r\017\021\017\036 \221\205\215 \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\027\036\005\021\030\024\023\036\027\017\036\005 \026\f\f\024\006\017)Tj 0 Tc 0 Tw (-)Tj 0.002 Tc 0.171 Tw T* [(\017\030\024\r\026\027\024 )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC 4.732 0 Td [(\r\t\f\024\022\024\005 )0.5(\004\026\f\021\024\021\024\005 )0.5(\f\036\023\f\017\f\026. )0.5(\200\024 )0.5(\r\f\036\b )0.5(\f\035\031)]TJ 0 Tc 0 Tw (-)Tj 0.002 Tc 0.409 Tw -4.732 -1.218 Td [(\004\026\016\b \r\t\016\r\035\036\027\017\016 \221\205\215 \f\035\036\007\ \031\036\021 \026\022\021\017\r\027\024 \023\030\024\r\024\007\017\021\034\ )2( )]TJ 0.156 Tw T* (\007\017\026\020\027\024\f\021\017\022\031, \027\026\023\030\026\r\035\036\ \027\027\031\033 \027\026)Tj /Span<>> BDC ( )Tj EMC (\r\t\007\036\035\036\027\017\036 \r\024\002\031\007\017)Tj 0 Tc 0 Tw (-)Tj 0.002 Tc 0.074 Tw T* (\021\036\035\016 \022\026\022 \r)Tj /Span<>> BDC ( )Tj EMC (\035\024\022\031\f\036 \r\024\f\023\026\035\036\027\017\016, \021\026\022\ \017)Tj /Span<>> BDC ( )Tj EMC [(\r \020\036\n\024\022\031\035\034\021\031\030\036.)2( )]TJ 0.055 Tw T* (\214\036\004\036\027\017\036 \023\026\006\017\036\027\021\024\r \f\024 \221\ \205\215 \017)Tj /Span<>> BDC ( )Tj EMC [(\022\035\017\027\017\022\024-\035\026\002\024\030\026\021\024\030\027\024\ \005)2( )]TJ 0.116 Tw T* [(\022\026\030\021\017\027\024\005 )0.5(\f\036\023\f\017\f\026 )0.5(\007\024\035\032\027\024 )0.5(\023\030\024\r\024\007\017\021\034\f\016 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 17.763 0 Td [(\024\021\007\036\035\036\027\017\017)2( )]TJ 0.055 Tw -17.763 -1.218 Td (\030\036\026\027\017\n\026\006\017\017 \r)Tj /Span<>> BDC ( )Tj EMC (\f\r\016\017 \f)Tj /Span<>> BDC ( )Tj EMC (\031\020\030\024\024\005 \030\026\r\017\021\017\016 \f\036\023\021\017\ \004\036\f\022\024)Tj 0 Tc 0 Tw (-)Tj 0.002 Tc 0.194 Tw T* [(\020\024 \001\024\022\026. \210\f\027\024\r\027\t\n\017 \n\036\021\024\007\ \026\n\017 \022\024\027\021\030\024\035\016 \017\027\235\036\022\006\017\ \017)2( )]TJ 0.259 Tw T* (\016\r\035\016\033\021\f\016 \007\030\036\027\017\030\024\r\026\027\017\036\ \026\002\f\006\036\f\f\024\r \017)Tj /Span<>> BDC ( )Tj EMC (\026\027\021\017\002\026\022\021\036\030\017)Tj 0 Tc 0 Tw (-)Tj 0.002 Tc 0.026 Tw T* (\026\035\034\027\026\016 \021\036\030\026\023\017\016, \022\024\021\024\030\ \026\016 \007\024\035\032\027\026 \002\t\021\034 \027\026\004\026\021\026\ \007\024)Tj /Span<>> BDC ( )Tj EMC (\024\023\036)Tj 0 Tc 0 Tw (-)Tj 0.002 Tc 0.203 Tw T* [(\030\026\006\017\017 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 3.914 0 Td [(\023\030\024\007\024\035\032\036\027\026 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 6.443 0 Td [(\023\024\f\035\036\024\023\036\030\026\006\017\024\027\027\024\n )0.5(\023\036\030\017\024)]TJ 0 Tc 0 Tw (-)Tj 0.002 Tc 0.197 Tw -10.357 -1.218 Td (\007\036 \007\024)Tj /Span<>> BDC ( )Tj EMC 2.828 0 Td [(\027\024\030\n\024\021\036\030\n\017\017 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC [(\030\036\020\030\036\f\f\026 )0.5(\n\036\f\021\027\t\b \023\030\017\027\026\022\024\r)2( )]TJ 0.325 Tw -2.828 -1.218 Td [(\r\024\f\023\026\035\036\027\017\016. \200\026\022\031\031\n-\021\036\030\ \026\023\017\016 )0.5(\016\r\035\016\036\021\f\016 )0.5(\002\036\024\023\026\f\027\t\n)2( )]TJ 0.346 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\220\235\235\036\022\021\017\r\027\t\n \n\036\021\024\007\024\n \r)Tj /Span<>> BDC ( )Tj EMC [(\022\024\n\023\035\036\022\f\027\024\n \035\036\004\036\027\017\017)2( )]TJ 0.541 Tw T* (\024\002\001\017\030\027\t\b \023\024\f\035\036\024\023\036\030\026\006\017\ \024\027\027\t\b \030\026\027 \031)Tj /Span<>> BDC ( )Tj EMC [(\023\026\006\017\036\027\021\024\r)2( )]TJ 0 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\027\036\005\021\030\024\023\036\027\017\036\005.)Tj /T1_2 1 Tf 0 Tc 0.023 Tw 0 -2.436 TD (\223\030\032\255\020\034\036 \032\026\020\017\022\017\026)Tj /T1_0 1 Tf 0.118 Tw 0 -1.218 TD [(\025)-4.1(\024)-4.3(\027)1.7(\006)-6(\036)-6.8(\023)2.2(\006)-6(\017)-5.4(\016 \017)]TJ /Span<>> BDC ( )Tj EMC [(\007)-6(\017)2.7()-9.9(\026\005)1.8(\027 \017)-2.4(\f)3.1(\f)-38.9(\035)-6.8(\036)-19(\007)-4.4(\024)-4.3(\r)-8.9(\026\027)1.7(\017)-5.4(\016)13.7(:)]TJ /T1_3 1 Tf -0.01 Tc 0.128 Tw [( \231)2.9(\024)-2.6(\020)-1.7(\032)-4.1(\013\n\027)-7.9(\026)]TJ /Span<>> BDC 20.047 0 Td ( )Tj EMC [(\207)-12.1(.)18.6(\216)14.3(.)-2.2(,)-10( )]TJ 0.01 Tw -20.047 -1.218 Td [(\200)1.3(\026)-5.7(\021\025\001)-3.5(\002\021)]TJ /Span<>> BDC 3.714 0 Td ( )Tj EMC [(\222)-1.4(.)19.3(\215)18.9(.)]TJ /T1_0 1 Tf 0 Tc 0.543 Tw -3.714 -1.218 Td [(\221)-4.6(\002)-9.9(\024)0.7(\030 \017)]TJ /Span<>> BDC ( )Tj EMC [(\024)-11.8(\002)3(\030)-11.4(\026)-6.3(\002)-9.9(\024)-10.9(\021)-17.7(\022)-19.1(\026 \n)1.4(\026)-11.8(\021)-9.9(\036)-1.7(\030)-7.6(\017)-0.6(\026)-33.1(\035)-2.5(\024)-4.3(\r)10.4(:)]TJ /T1_3 1 Tf -0.01 Tc 0.553 Tw [( \231)2.9(\024)-2.7(\020)-1.7(\032)-4.1(\013\n\027)-7.9(\026)]TJ /Span<>> BDC 19.621 0 Td ( )Tj EMC [(\207)-12.1(.)18.5(\216)14.3(.)-2.2(,)-10( )]TJ 0 Tc 0 Tw -19.621 -1.218 Td [(\207)6.8(\n)-4.1(\005)1.1(\n)10.1(\023)3.3(\031)6.7(\027)2.1(\026)]TJ /Span<>> BDC ( )Tj EMC [(\255)27.6(.)7.3(\201)-2.3(.)7.8(, \207)7.9(\026)-1.2(\005)8.1(\025)4.7(\032\n)9.6(\027)]TJ /Span<>> BDC ( )Tj EMC [(\222)8.6(.)29.3(\212)93.9(.)]TJ /T1_0 1 Tf 0.002 Tc 0.345 Tw T* [(\203)7.2(\026\023)4.2(\017\f)-10.8(\026)1.7(\027)3.7(\017)-6.7(\036)2.1( )0.5(\021)-7.9(\036)-3.4(\022\f)-34(\021)-19.5(\026)5.7(:)]TJ /T1_3 1 Tf -0.007 Tc 0.354 Tw 8.04 0 Td [( )0.5(\231)5.9(\024\020)1.3(\032)-1.1(\013)2.8(\n)2.6(\027)-4.9(\026)]TJ /Span<>> BDC 5.055 0 Td ( )Tj EMC 0.579 0 Td [(\207)-9.1(.)21.5(\216)17.3(.)0.8(,)-7( )0.5(\207\n)-11.1(\005)-5.9(\n)3.1(\023)-3.7(\031\027)-4.9(\026)]TJ /Span<>> BDC 6.026 0 Td ( )Tj EMC 0.579 0 Td [(\255)20.6(.\201)-9.3(.)0.8(,)-7( )]TJ -0.008 Tc 0.008 Tw -20.28 -1.218 Td [(\207\026)-9.2(\005\025)-3.2(\032)-7.9(\n)1.6(\027)]TJ /Span<>> BDC 3.301 0 Td ( )Tj EMC [(\222)0.6(.)21.3(\212)85.9(.)]TJ /T1_0 1 Tf 0 Tc 0 Tw -3.301 -1.218 Td [(\217)5.5(\036)-19(\007)-20.1(\026\022)-32.6(\021)-17.7(\017)1.5(\030)-11.8(\024)-4.4(\r)-8.8(\026\027)1.8(\017)-8.7(\036)6.5(:)]TJ /T1_3 1 Tf -0.01 Tc 0.817 Tw [( \200)1.3(\026)-5.6(\021\025\001)-3.6(\002\021)]TJ /Span<>> BDC 11.889 0 Td ( )Tj EMC [(\222)-1.4(.)19.4(\215)18.8(.)-2.2(,)-10( \217)1.7(\n\027)-4.4(\025)-2.3(\013\n\027)]TJ /Span<>> BDC 7.345 0 Td ( )Tj EMC [(\216)14.3(.)-2.6(\201)-12.3(.)-2.2(,)-10( )]TJ 0.01 Tw -19.233 -1.218 Td [()5.1(\026)-8.2(\032)-9.8(\n\027)-4.5(\025)9.3(\006\021\025)-2.3(\013\n\027)-7.9(\026)]TJ /Span<>> BDC 6.213 0 Td ( )Tj EMC [(\036)12.8(.)19.3(\217)18.8(.)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 0 Tc 0 Tw 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\033\030\031\030\213\b)-20.9(\035\231\213\233\t \021\032)50(\b)42(\032\231\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj -51.938 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 23, \023\0221)69(, 202)69(4)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 23, \023\0221)69(, 202)69(4)]TJ /T1_5 1 Tf 25 0 0 25 20.7776 56.0378 Tm (126)Tj ET endstream endobj 34 0 obj <> endobj 35 0 obj <> endobj 36 0 obj <> endobj 37 0 obj <> endobj 38 0 obj <> endobj 1184 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1185 0 obj <>/Font<>/ProcSet[/PDF/Text/ImageC]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1186 0 obj <>/Font<>/ProcSet[/PDF/Text/ImageC]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1187 0 obj <>/Font<>/ProcSet[/PDF/Text/ImageC]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1188 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1201 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\255\220\013\202\001\025\006)-9.9(\026\220\n\013 \220\022\007\016\017\016\001\220\016 \006)-10(\007\025\217\001\020\207 \225\025\002\024 \025\006)-10(\026\002\025\202)10(\025 \221\013\002\013\221\002\025\n)-10(\026\220\026)11(\013 )]TJ 0 -1 TD [(\215\022\221\013\227\220\016\001\026)11.1(\025\r \006\022\025\221\215)21(\207\025\007\016\r\020\024\220 \222\013\f\025\007\016\r\013\001\220\205\024\ \220 \006\220\006)-10(\026)11(\016\024\020 \n\002\025\r\220)]TJ 40.547 1 Td [(Diagnostics and tr)31(eatment of complicated perianal )]TJ 0.208 -1 Td [(abscess in patients with h)11(ematologic malignancies)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0.152 Tw 10 0 0 10 42.5197 724.8299 Tm (\027\036\005\021\030\024\023\036\027\017\033 \(\217\017\f.)Tj /Span<>> BDC ( )Tj EMC (4\), \r)Tj /Span<>> BDC ( )Tj EMC (\030\026\n\022\026\b \035\036\004\036\027\017\016 \024\f\027\024\r\027\024\ \020\024 )Tj 0.096 Tw 0 -1.218 TD (\026\002\024\035\036\r\026\027\017\016 \002\t\035\024 \023\030\024\r\036\ \007\036\027\024 10 \f\036\026\027\f\024\r \023\035\026\n\026\235\036)Tj 0 Tw (-)Tj 0.22 Tw T* (\030\036\026, \023\031\035\034\f \021\036\030\026\023\017\016 \n\036\021\ \017\035\023\030\036\007\027\017\024\035\024\027\024\n \(1000 \n\020 )Tj 0.05 Tw T* (\r\027\031\021\030\017\r\036\027\027\024 \2253\). \215\024\f\035\036 \r\r\ \036\007\036\027\017\016 \206\025\221, \002\t\035\026 \007\024\f\021\017\ \020)Tj 0 Tw (-)Tj 0.099 Tw T* (\027\031\021\026 \027\024\030\n\024\021\036\030\n\017\016, \024\007\027\026\ \022\024 \f\031\013\036\f\021\r\036\027\027\t\b \017\n\036\027\036\027\017\ \005 )Tj 0 Tw T* (\020\036\n\024\020\030\026\n\n\t \023\024\035\031\004\036\027\024 \027\036\ \002\t\035\024.)Tj 0.012 Tc 0.609 Tw 0 -1.218 TD (\215\026\006\017\036\027\021 \027\026\002\035\033\007\026\035\f\016 \r)Tj /Span<>> BDC ( )Tj EMC [(\024\021\007\036\035\036\027\017\017 \030\036\026\027\017\n\026\006\017\017\ )12( )]TJ 0.114 Tw 0 -1.218 TD (\r)Tj /Span<>> BDC ( )Tj EMC [(\021\036\004\036\027\017\036 35 \007\027\036\005. \215\024\f\035\036 \f\021\ \026\002\017\035\017\026\006\017\017 \f\024\f\021\024\016\027\017\016)12( )]TJ 0.348 Tw T* (\023\026\006\017\036\027\021\026 \023\030\024\r\024\007\017\035\026\f\034\ \007\036\220\f\022\026\035\026\006\017\016 \026\027\021\017\002\026\022\ \021\036\030\017)Tj 0 Tc 0 Tw (-)Tj 0.012 Tc -0.039 Tw T* (\026\035\034\027\024\005 \021\036\030\026\023\017\017 \(\023\030\036\007\ \t\007\031\013\026\016 \f\b\036\n\026 \026\n\036\027\036\027\026 \027\026\ )Tj /Span<>> BDC ( )Tj EMC (\n\036)Tj 0 Tc 0 Tw (-)Tj 0.012 Tc 0.095 Tw T* (\030\024\023\036\027\036\n \017)Tj /Span<>> BDC ( )Tj EMC (\026\n\017\022\026\006\017\027 \017)Tj /Span<>> BDC ( )Tj EMC (\007\026\035\036\036 \027\026)Tj /Span<>> BDC ( )Tj EMC [(\n\024\022\f\017\235\035\024\022\f\026\006\017\027\).)12( )]TJ 0.216 Tw T* (\221\031\n\n\026\030\027\026\016 \007\035\017\021\036\035\034\027\024\f\021\ \034 \026\027\021\017\002\026\022\021\036\030\017\026\035\034\027\024\005\ \021\036\030\026)Tj 0 Tc 0 Tw (-)Tj 0.012 Tc 0.084 Tw 0 -1.218 TD [(\023\017\017 \f\024\f\021\026\r\017\035\026 )0.5(40 \007\027\036\005. \223\036\030\036 )0.5(1,5 \n\036\f\016\006\026 \002\t\035\026 )0.5(\r\t)]TJ 0 Tc 0 Tw (-)Tj 0.012 Tc 0.025 Tw 0 -1.218 TD (\023\024\035\027\036\027\026 \023\035\026\f\021\017\022\026 \022\024\032\ \027\024\020\024 \007\036\235\036\022\021\026. \215\024\035\027\024\036 \ \026\032\017\r)Tj 0 Tc 0 Tw (-)Tj 0.012 Tc 0.189 Tw 0 -1.218 TD [(\035\036\027\017\036 )0.5(\030\026\027\t )0.5(\007\024\f\021\017\020\027\031\021\024 )0.5(\004\036\030\036 )0.5(2,5 )0.5(\n\036\f\016\006\026 )0.5(\027\026)]TJ /Span<>> BDC ( )Tj EMC 19.93 0 Td [(\235\024\027\036)12( )]TJ 0.435 Tw -19.93 -1.218 Td (\f\024\b\030\026\027\016\033\013\036\005\f\016 \027\036\005\021\030\024\023\ \036\027\017\017 \(\217\017\f.)Tj /Span<>> BDC ( )Tj EMC [(1\020-\007\). \223\036\030\036)12( )]TJ 0.003 Tw T* (8)Tj /Span<>> BDC ( )Tj EMC (\n\036\f\016\006\036\r \(13.12.2022\) \r\t\023\024\035\027\036\027\024 \ \026\022\030\t\021\017\036 \f\017\020\n\024)Tj 0 Tc 0 Tw (-)Tj 0.012 Tc T* (\f\021\024\n\t \002\036 \024\f\035\024\032\027\036\027\017\005.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 42.5896 481.2698 Tm [(\037\036)10(\032\223\212\226\034\022\031\034)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0 Tc 0.04 Tw 10 0 0 10 42.5197 456.9138 Tm (\223\026\f\021\024\021\026 \030\026\r\017\021\017\016 \221\205\215, \023\ \024)Tj /Span<>> BDC ( )Tj EMC (\007\026\027\027\t\n \027\026\f\021\024\016\013\036\020\024 \017\f\f\035\ \036)Tj 0 Tw (-)Tj T* (\007\024\r\026\027\017\016, \f\024\f\021\026\r\035\016\036\021 8,97% \f\035\ \031\004\026\016 \215\222.)Tj 0.051 Tw T* (\217\026\r\017\021\017\036 \221\205\215 \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\024\027\022\024\020\036\n\026\021\024\035\024\020\017\004\036\f\022\017\ \n\017 )Tj 0.197 Tw T* [(\026\002\024\035\036\r\026\027\017\016\n\017 )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC 7.742 0 Td [(\027\036\005\021\030\024\023\036\027\017\036\005 )0.6(\004\026\f\021\024 )0.5(\016\r\035\016\036\021\f\016 )0.6(\030\036)]TJ 0 Tw (-)Tj 0.12 Tw -7.742 -1.218 Td (\031\035\034\021\026\021\024\n \027\036\220\235\235\036\022\021\017\r\027\ \024\f\021\017 \023\030\036\007\t\007\031\013\017\b \220\021\026\023\024\ \r \035\036)Tj 0 Tw (-)Tj 0.019 Tw T* (\004\036\027\017\016 \023\036\030\017\026\027\026\035\034\027\024\005 \017\ \027\235\036\022\006\017\017. \221\205\215 \n\024\020\031\021 \030\026\r\ \017\021\034\f\016 )Tj 0.106 Tw T* (\022\026\022 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\027\036\220\235\235\036\022\021\017\r\027\024\f\021\017 \022\024\027\f\036\ \030\r\026\021\017\r\027\024\020\024 \035\036\004\036\027\017\016 )Tj 0.512 Tw T* (\017\027\235\017\035\034\021\030\026\021\017\r\027\t\b \235\024\030\n \023\ \036\030\017\026\027\026\035\034\027\024\005 \017\027\235\036\022\006\017\ \017, )Tj 0.231 Tw T* (\021\026\022 \017)Tj /Span<>> BDC ( )Tj EMC (\r \030\036\031\035\034\021\026\021\036 \007\026\035\034\027\036\005\001\ \036\020\024 \023\030\024\020\030\036\f\f\017\030\024\r\026\027\017\016 \ )Tj 0.076 Tw T* (\023\030\024\006\036\f\f\026 \023\024\f\035\036 \024\023\036\030\026\021\ \017\r\027\024\020\024 \007\030\036\027\017\030\024\r\026\027\017\016 \023\ \030\017)Tj /Span<>> BDC ( )Tj EMC (\024\021)Tj 0 Tw (-)Tj 0.555 Tw T* (\f\031\021\f\021\r\017\017 \026\007\036\022\r\026\021\027\024\005 \026\027\ \021\017\002\026\022\021\036\030\017\026\035\034\027\024\005 \021\036\030\ \026\023\017\017 )Tj 0 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\023\024\f\035\036\024\023\036\030\026\006\017\024\027\027\024\n \023\036\ \030\017\024\007\036.)Tj 0.17 Tw T* (\215\030\017 \024\002\f\035\036\007\024\r\026\027\017\017 \023\026\006\017\ \036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\024\023\031\b\024\035\016\n\017 \f\017\f\021\036\n\t )Tj 0.218 Tw T* (\022\030\024\r\017 \f\035\036\007\031\036\021 \023\030\017\027\017\n\026\ \021\034 \r\024 \r\027\017\n\026\027\017\036, \004\021\024 \022\035\017\027\ \017)Tj 0 Tw (-)Tj 0.118 Tw T* (\004\036\f\022\017\036 \023\030\017\027\026\022\017 \017)Tj /Span<>> BDC ( )Tj EMC (\035\026\002\024\030\026\021\024\030\027\t\036 \023\024\022\026\026\021\ \036\035\017 \r)Tj /Span<>> BDC ( )Tj EMC (\027\026)Tj 0 Tw (-)Tj 0.251 Tw T* (\004\017\021\036\035\034\027\024\005 \f\021\036\023\036\027\017 \026\r\017\ \f\016\021 \024\021 \021\026\022\017\b \235\026\022\021\024\030\024\r \022\ \026\022 )Tj 0.174 Tw T* (\023\024\030\026\032\036\027\017\036 \022\030\024\r\036\021\r\024\030\027\ \024\005 \f\017\f\021\036\n\t, \023\030\017\n\036\027\036\027\017\036 \206\ \025\221 )Tj 0.118 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\006\017\021\024\f\021\026\021\017\022\024\r, \027\026\035\017\004\017\016\ \n\027\024\032\036\f\021\r\036\027\027\t\b \024\004\026\020\024\r \017\027\ )Tj 0 Tw (-)Tj 0.041 Tw T* (\235\036\022\006\017\017. \200)Tj /Span<>> BDC ( )Tj EMC (\007\026\027\027\024\n \017\f\f\035\036\007\024\r\026\027\017\017 \027\026\ )Tj /Span<>> BDC ( )Tj EMC (\n\024\n\036\027\021 \007\017\026\020\027\024\f)Tj 0 Tw (-)Tj 0.173 Tw T* (\021\017\022\017 \017\027\235\036\022\006\017\017 \031)Tj /Span<>> BDC ( )Tj EMC (\r\f\036\b \023\026\006\017\036\027\021\024\r \030\036\020\017\f\021\030\ \017\030\024\r\026\035\026\f\034 )Tj 0.08 Tw T* (\027\036\005\021\030\024\023\036\027\017\016. \203\026\035\017\004\017\036\ \035\017\b\024\030\026\007\022\017 \027\036 \022\024\030\030\036\035\017\ \030\024\r\026\035\024 )Tj 0.103 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC 0.772 0 Td [(\030\026\027\036\r\t\n )0.5(\023\030\024\006\036\f\f\024\n )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC 9.551 0 Td [(\004\026\f\021\024 )0.5(\026\r\017\f\036\035\024 )0.6(\024\021 )0.5(\023\030\017\n\036\027\036)]TJ 0 Tw (-)Tj 0.232 Tw -10.324 -1.218 Td (\027\017\016 \206\221\025. \230\026\022\017\n \024\002\030\026\024\n, \023\ \030\026\r\017\035\034\027\026\016 \024\006\036\027\022\026 \n\036\f\021\ )Tj 0 Tw (-)Tj 0.113 Tw T* (\027\024\020\024 \f\021\026\021\031\f\026 \016\r\035\016\036\021\f\016 \024\ \f\027\024\r\027\t\n \017)Tj /Span<>> BDC ( )Tj EMC (\004\026\f\021\024 \036\007\017\027\f\021\r\036\027)Tj 0 Tw (-)Tj 0.152 Tw T* (\027\t\n \022\030\017\021\036\030\017\036\n \022\026\022 \007\035\016 \031\ \f\021\026\027\024\r\035\036\027\017\016 \007\017\026\020\027\024\026, \ \021\026\022 )Tj 0.331 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\007\035\016 \023\024\f\035\036\007\031\033\013\036\020\024 \n\024\027\017\ \021\024\030\017\027\020\026 \017\027\235\036\022\006\017\024\027\027\024\ \020\024 )Tj 0.252 Tw T* (\023\030\024\006\036\f\f\026. \200\026\032\027\024 \031\004\017\021\t\r\026\ \021\034, \004\021\024 \017\027\r\026\017\r\027\t\036 \007\017\026\020)Tj 0 Tw (-)Tj 0.304 Tw T* (\027\024\f\021\017\004\036\f\022\017\036 \023\030\024\006\036\007\031\030\ \t \(\030\036\022\021\026\035\034\027\024\036 \017\f\f\035\036\007\024\r\ \026\027\017\036 )Tj 0.333 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\030\036\022\021\024\f\022\024\023\017\017\) \031)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\005 \022\026\021\036\020\024\030\017\017 \002\024\035\034\027\ \t\b \f\r\016\026)Tj 0 Tw (-)Tj 0.228 Tw T* (\027\t \f)Tj /Span<>> BDC ( )Tj EMC (\024\023\026\f\027\024\f\021\034\033 \007\017\f\f\036\n\017\027\026\006\017\ \017 \017\027\235\036\022\006\017\017 \r)Tj /Span<>> BDC ( )Tj EMC (\021\022\026\027\017 )Tj 0.025 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\022\030\024\r\024\021\024\022 [4]. \212\026\027\027\t\036 \022\035\017\027\ \017\004\036\f\022\024\020\024 \024\f\n\024\021\030\026 \031)Tj /Span<>> BDC ( )Tj EMC (\007\026\027)Tj 0 Tw (-)Tj 0.229 Tw T* [(\027\024\005 )0.5(\022\026\021\036\020\024\030\017\017 )0.6(\023\026\006\017\036\027\021\024\r )0.5(\007\024\035\032\027\t )0.5(\002\t\021\034 )0.5(\007\024\023\024\035\027\036\027\t )]TJ 0.156 Tw 23.244 64.543 Td (\n\036\021\024\007\026\n\017 \024\002\255\036\022\021\017\r\027\024\005 \ \r\017\031\026\035\017\026\006\017\017, \017\f\022\035\033\004\026\033\ \013\017)Tj 0 Tw (-)Tj 0 -1.218 TD (\n\017 \017\027\r\026\017\r\027\024\036 \r\024\007\036\005\f\021\r\017\ \036 \027\026)Tj /Span<>> BDC ( )Tj EMC (\024\004\026\020 \017\027\235\036\022\006\017\017.)Tj 0.246 Tw 0 -1.218 TD [(\200 \027\026\f\021\024\016\013\036\036 )0.5(\r\030\036\n\016 )0.5(\204\217\230 \016\r\035\016\036\021\f\016 )0.5(\n\036\021\024\007\024\n )0.5(\r\t\002\024\030\026 )]TJ 0.052 Tw 0 -1.218 TD (\007\035\016 \007\017\026\020\027\024\f\021\017\022\017 \026\027\024\030\ \036\022\021\026\035\034\027\t\b \026\002\f\006\036\f\f\024\r \017)Tj /Span<>> BDC ( )Tj EMC (\f\r\017\013\036\005 )Tj 0 Tw 0 -1.218 TD (\031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\020\036\n\024\002\035\026\f\021\024\026\n\017 [13,14]. \215\024\n\017\n\ \024 \r\t\f\024)Tj (-)Tj 0.153 Tw 0 -1.218 TD (\022\024\005 \007\017\026\020\027\024\f\021\017\004\036\f\022\024\005 \021\ \024\004\027\024\f\021\017, \024\021\f\031\021\f\021\r\017\016 \017\027\r\ \026\017\r)Tj 0 Tw (-)Tj 0.076 Tw 0 -1.218 TD (\027\024\020\024 \r\024\007\036\005\f\021\r\017\016, \023\030\036\017\n\ \031\013\036\f\021\r\024\n \204\217\230 \016\r\035\016\036\021\f\016 \001\ \017)Tj 0 Tw (-)Tj 0.156 Tw 0 -1.218 TD [(\030\024\022\024\036 )0.5(\023\024\035\036 )0.5(\r\017\031\026\035\017\026\006\017\017, )0.5(\004\021\024 )0.5(\023\024\r\024\035\016\036\021 )0.5(\023\030\024\r\024\007\017\021\034 )]TJ 0.143 Tw T* (\007\017\235\235\036\030\036\027\006\017\026\035\034\027\031\033 \007\017\ \026\020\027\024\f\021\017\022\031 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\023\024\017\f\022\036 \024\004\026\020\024\r )Tj 0.06 Tw T* (\017\027\235\036\022\006\017\017. \200)Tj /Span<>> BDC ( )Tj EMC (\027\026\f\021\024\016\013\036\n \017\f\f\035\036\007\024\r\026\027\017\017\ \204\217\230 \016\r\035\016\035\026\f\034 )Tj -0.007 Tw T* (\027\036\024\002\b\024\007\017\n\t\n \017\027\f\021\030\031\n\036\027\021\ \024\n \022\026\022 \007\035\016 \007\017\026\020\027\024\f\021\017\022\017\ , \021\026\022 )Tj 0.004 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\007\035\016 \024\006\036\027\022\017 \007\017\027\026\n\017\022\017 \017\ \027\235\036\022\006\017\024\027\027\024\020\024 \023\030\024\006\036\f\f\ \026 \023\024)Tj 0 Tw (-)Tj T* (\f\035\036 \024\023\036\030\026\006\017\017.)Tj 0.129 Tw T* (\217\026\r\017\021\017\036 \221\205\215 \027\026)Tj /Span<>> BDC ( )Tj EMC (\235\024\027\036 \027\036\005\021\030\024\023\036\027\017\017 \026\f\f\024\ \006\017\017\030\024\r\026\027\024 )Tj 0.228 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\022\030\026\005\027\036 \021\016\032\036\035\t\n \f\024\f\021\024\016\027\ \017\036\n \023\026\006\017\036\027\021\024\r, \r\t\f\024\022\024\005 )Tj 0.39 Tw T* (\004\026\f\021\024\021\024\005 \f\036\023\f\017\f\026, \031\020\030\024\ \024\005 \030\026\r\017\021\017\016 \f\036\023\021\017\004\036\f\022\024\ \020\024 )Tj 0.027 Tw T* (\001\024\022\026. \200\024 \r\f\036\b \f\035\031\004\026\016\b \017\027\235\ \036\022\006\017\024\027\027\024\020\024 \023\030\024\006\036\f\f\026 \f\ \035\036)Tj 0 Tw (-)Tj 0.123 Tw T* (\007\031\036\021 \026\022\021\017\r\027\024 \023\030\024\r\024\007\017\021\ \034 \007\017\026\020\027\024\f\021\017\022\031, \027\026\023\030\026\r\035\ \036\027\027\031\033 )Tj 0.14 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC (\r\t\016\r\035\036\027\017\036 \022\026\022 \024\004\026\020\024\r \017\027\ \235\036\022\006\017\017, \021\026\022 \017)Tj /Span<>> BDC ( )Tj EMC (\r\024\002\031\007\017)Tj 0 Tw (-)Tj 0.107 Tw T* (\021\036\035\016. \211)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\027\036\005\021\030\024\023\036\027\017\036\005 \027\036\024\002\b\024\007\ \017\n\024 \023\030\024)Tj 0 Tw (-)Tj 0.162 Tw T* (\r\024\007\017\021\034 \022\026\022 \035\024\022\026\035\034\027\024\036\ \r\t\007\036\035\036\027\017\036 \r\024\002\031\007\017\021\036\035\036\ \005, \021\026\022 )Tj 0.107 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\n\024\027\017\021\024\030\017\027\020 \020\036\n\024\022\031\035\034\021\ \031\030\t. \215\024)Tj /Span<>> BDC ( )Tj EMC (\007\026\027\027\t\n \027\026\f\021\024\016\013\036\020\024 )Tj 0.254 Tw T* (\017\f\f\035\036\007\024\r\026\027\017\016, \004\026\f\021\024\021\026 \f\ \036\023\f\017\f\026 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\221\205\215 \f\024\f\021\026\r\017\035\026 )Tj -0.024 Tw T* (57,1%, \004\021\024 \f\031\013\036\f\021\r\036\027\027\024 \r\t\001\036,\ \004\036\n \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\007\030\031\020\017\b \235\024\030\n\026\b )Tj 0.165 Tw T* (\215\222 20\22630% [4,8]. \215\026\006\017\036\027\021\026\n \f)Tj /Span<>> BDC ( )Tj EMC (\022\035\017\027\017\022\024-\035\026\002\024\030\026\021\024\030)Tj 0 Tw (-)Tj 0.105 Tw T* (\027\024\005 \022\026\030\021\017\027\024\005 \f\036\023\f\017\f\026 \023\ \024\022\026\026\027\024 \035\036\004\036\027\017\036 \r)Tj /Span<>> BDC ( )Tj EMC (\031\f\035\024\r\017\016\b )Tj 0.025 Tw T* (\024\021\007\036\035\036\027\017\016 \030\036\026\027\017\n\026\006\017\017\ . \200)Tj /Span<>> BDC ( )Tj EMC (\007\026\027\027\024\n \017\f\f\035\036\007\024\r\026\027\017\017 \f\030\ \024)Tj 0 Tw (-)Tj 0.048 Tw T* (\022\017 \035\036\004\036\027\017\016 \r)Tj /Span<>> BDC ( )Tj EMC (\210\217\222\230 \002\t\035\017 \007\035\017\021\036\035\034\027\t\n\017\ , \r)Tj /Span<>> BDC ( )Tj EMC (\f\030\036\007\027\036\n, 32 )Tj 0.064 Tw T* (\007\027\016. \203\036\f\n\024\021\030\016 \027\026)Tj /Span<>> BDC ( )Tj EMC (\r\t\f\024\022\031\033 \004\026\f\021\024\021\031 \017\027\235\036\022\006\ \017\005 \022\030\024\r\024)Tj 0 Tw (-)Tj 0.1 Tw T* (\021\024\022\026, \035\036\021\026\035\034\027\024\f\021\017, \f\r\016\026\ \027\027\024\005 \027\036\023\024\f\030\036\007\f\021\r\036\027\027\024 \ \f)Tj /Span<>> BDC ( )Tj EMC (\023\026)Tj 0 Tw (-)Tj T* (\030\026\023\030\024\022\021\017\021\024\n, \027\036 \002\t\035\024.)Tj 0.012 Tc 0.467 Tw T* (\003\026\007\026\004\017 \b\017\030\031\030\020\017\004\036\f\022\024\020\ \024 \035\036\004\036\027\017\016 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\221\205\215 \024\f\021\026)Tj 0 Tc 0 Tw (-)Tj 0.012 Tc 0.356 Tw T* (\033\021\f\016 \027\036\017\n\036\027\027\t\n\017)Tj /Span<>> BDC ( )Tj EMC [(\227 \026\007\036\022\r\026\021\027\024\036 \007\030\036\027\017\030\024\ \r\026\027\017\036)12( )]TJ 0.36 Tw T* (\023\024\035\024\f\021\036\005 \017)Tj /Span<>> BDC ( )Tj EMC [(\026\021\036\022\024\r, \031\007\026\035\036\027\017\036 \027\036\022\030\ \024\024\r. \210\007\027\026\022\024)12( )]TJ 0.286 Tw T* (\031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\027\036\005\021\030\024\023\036\027\017\036\005 \021\024\035\034\022\024\ \024\023\036\030\026\021\017\r\027\024)Tj 0 Tc 0 Tw (-)Tj 0.012 Tc 0.36 Tw T* [(\020\024 \007\030\036\027\017\030\024\r\026\027\017\016 \027\036\007\024\ \f\021\026\021\024\004\027\024 \007\035\016 \022\031\023\017\030\024\r\026\ \027\017\016)12( )]TJ 0.434 Tw T* [(\017\027\235\036\022\006\017\024\027\027\024\020\024 \023\030\024\006\036\ \f\f\026. \200\026\032\027\036\005\001\017\n \235\026\022\021\024\030\024\ \n)12( )]TJ 0.454 Tw T* (\017\035\036\004\036\027\017\016 \016\r\035\016\036\021\f\016 \026\007\036\ \022\r\026\021\027\026\016 \026\027\021\017\002\026\022\021\036\030\017\026\ \035\034)Tj 0 Tc 0 Tw (-)Tj 0.012 Tc 0.158 Tw T* (\027\026\016 \021\036\030\026\023\017\016, \022\024\021\024\030\026\016 \ \007\024\035\032\027\026 \002\t\021\034 \027\026\004\026\021\026 \007\024\ )Tj /Span<>> BDC ( )Tj EMC (\024\023\036)Tj 0 Tc 0 Tw (-)Tj 0.012 Tc 0.114 Tw T* (\030\026\006\017\017 \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\007\024\035\032\036\027\026 \r)Tj /Span<>> BDC ( )Tj EMC [(\023\024\f\035\036\024\023\036\030\026\006\017\024\027\027\024\n )-0.6(\023\036\030\017\024)]TJ 0 Tc 0 Tw (-)Tj 0.012 Tc 0.122 Tw T* (\007\036 \007\024)Tj /Span<>> BDC ( )Tj EMC (\027\024\030\n\024\021\036\030\n\017\017 \017)Tj /Span<>> BDC ( )Tj EMC [(\030\036\020\030\036\f\f\026 \n\036\f\021\027\t\b \023\030\017\027\026\022\ \024\r)12( )]TJ -0.012 Tw T* (\r\024\f\023\026\035\036\027\017\016.)Tj 0 Tc 0.09 Tw T* [(\210\021\022\035\033\004\036\027\017\036 )0.6(\023\026\f\f\026\032\026 )0.5(\023\024)]TJ /Span<>> BDC ( )Tj EMC 10.37 0 Td [(\023\030\016\n\024\005 )0.5(\022\017\001\022\036, )0.6(\021\024 )0.5(\036\f\021\034 )0.5(\235\024\030)]TJ 0 Tw (-)Tj 0.258 Tw -10.37 -1.218 Td (\n\017\030\024\r\026\027\017\036 \022\017\001\036\004\027\024\005 \f\021\ \024\n\t \027\036 \016\r\035\016\036\021\f\016 \030\031\021\017\027\027\024\ \005 )Tj 0.36 Tw T* [(\024\023\036\030\026\006\017\036\005 )0.5(\023\030\017)]TJ /Span<>> BDC ( )Tj EMC [(\023\026\030\026\023\030\024\022\021\017\021\026\b. Mar)-24(k)-10(s )0.5(G. \017)]TJ /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. )Tj 0.207 Tw T* (\023\030\024\026\027\026\035\017\017\030\024\r\026\035\017 11 \f\n\036\030\ \021\036\005, \f\r\016\026\027\027\t\b \f\024 \023\026\030\026)Tj 0 Tw (-)Tj 0.188 Tw T* (\030\036\022\021\026\035\034\027\t\n\017 \026\002\f\006\036\f\f\026\n\017\ , \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\024\002\013\017\035\017, \004\021\024 \027\026\035\024\032\036)Tj 0 Tw (-)Tj 0.096 Tw T* (\027\017\036 \022\017\001\036\004\027\024\005 \f\021\024\n\t \027\036 \023\ \030\036\007\024\021\r\030\026\013\026\036\021 \f\036\023\021\017\004\036\ \f\022\017\b )Tj 0.184 Tw T* (\024\f\035\024\032\027\036\027\017\005 [15,16]. \230\026\022\032\036 \002\ \t\035\024 \023\024\022\026\026\027\024, \004\021\024 \027\026)Tj 0 Tw (-)Tj 0.187 Tw T* [(\035\024\032\036\027\017\036 )0.5(\022\024\035\024\f\021\024\n\t )0.6(\027\036 )0.5(\031\035\031\004\001\026\036\021 )0.5(\030\036\031\035\034\021\026\021\024\r )0.6(\035\036\004\036)]TJ 0 Tw (-)Tj 0.066 Tw T* (\027\017\016 \030\036\022\021\024\r\026\020\017\027\026\035\034\027\t\b \ \f\r\017\013\036\005 [16,17]. \215\024\022\026\026\027\017\016\n\017 )Tj 0.303 Tw T* (\022)Tj /Span<>> BDC ( )Tj EMC (\027\026\035\024\032\036\027\017\033 \022\024\035\024\f\021\024\n\t \023\ \026\006\017\036\027\021\026\n \r)Tj /Span<>> BDC ( )Tj EMC (\007\026\027\027\024\n \017\f)Tj 0 Tw (-)Tj 0.149 Tw T* (\f\035\036\007\024\r\026\027\017\017 \002\t\035\017 \024\002\001\017\030\ \027\026\016 \024\027\026 \023\024\030\026\032\036\027\017\016, \r\t\030\ \026)Tj 0 Tw (-)Tj 0.128 Tw T* [(\032\036\027\027\t\005 \002\024\035\036\r\024\005 \f\017\027\007\030\024\ \n, \007\035\017\021\036\035\034\027\026\016 )0.5(\027\036\005\021\030\024\023\036\027\017\016, )]TJ 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 0 Tw 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\033\030\031\030\213\b)-20.9(\035\231\213\233\t \021\032)50(\b)42(\032\231\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj /T1_3 1 Tf 25 0 0 25 505.4397 56.0378 Tm (125)Tj ET endstream endobj 1198 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 0 0 0 1 k /GS1 gs /T1_0 1 Tf 10 0 0 10 70.8661 724.8299 Tm (hominis.)Tj /T1_1 1 Tf 0.204 Tw ( \203\026\004\026\021\026 \026\027\021\017\002\026\022\021\036\030\017\026\ \035\034\027\026\016 \021\036\030\026\023\017\016, \021\030\026\027\f)Tj 0 Tw (-)Tj 0 -1.218 TD (\235\031\017\017, \023\026\030\036\027\021\036\030\026\035\034\027\024\036\ \023\017\021\026\027\017\036.)Tj -0.044 Tw T* (\200 \f\030\024\004\027\024\n \023\024\030\016\007\022\036 \r\t\023\024\035\ \027\036\027\026 \030\036\r\017\017\016 \030\026\027\t \023\030\024\n\036\ \032)Tj 0 Tw (-)Tj 0.264 Tw T* [(\027\024\f\021\017, )0.6(\007\030\036\027\017\030\024\r\026\027\017\036 )0.5(\023\036\035\034\r\017\024\030\036\022\021\026\035\034\027\024\020\024 )0.7(\026\002\f\006\036\f\f\026 )]TJ 0.255 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC 1.005 0 Td [(\026\021\036\022\024\r )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 4.621 0 Td [(\023\026\030\026\030\036\022\021\026\035\034\027\024\005 )0.6(\022\035\036\021\004\026\021\022\036, )0.6(\035\026\023\026\030\024\f\022\024)]TJ 0 Tw (-)Tj 0.092 Tw -5.626 -1.218 Td (\023\017\004\036\f\022\026\016 \f\017\020\n\024\f\021\024\n\017\016. \203\ \026)Tj /Span<>> BDC ( )Tj EMC (\021\030\036\021\034\017 \f\031\021\022\017 \031\f\021\026\027\024\r\035\ \036\027\026 )Tj 0.017 Tw 0 -1.218 TD (\r\026\022\031\031\n-\017\027\f\021\017\035\016\006\017\024\027\027\026\016\ \f\017\f\021\036\n\026 \(\217\017\f.)Tj /Span<>> BDC ( )Tj EMC (1\002\). \200)Tj /Span<>> BDC ( )Tj EMC (\023\024\035\024\f\021\034 )Tj 0.031 Tw 0 -1.218 TD (\026\002\f\006\036\f\f\026 \002\t\035 \031\f\021\026\027\024\r\035\036\027\ \007\030\036\027\026\032 \007\035\016 \r\r\036\007\036\027\017\016 \030\ \026\f\021)Tj 0 Tw (-)Tj 0.352 Tw T* (\r\024\030\024\r \026\027\021\017\f\036\023\021\017\022\024\r \017)Tj /Span<>> BDC ( )Tj EMC (\023\036\027\024\023\024\035\017\031\030\036\021\026\027\024\r\026\016 \020\ \031\002\022\026. )Tj 0.018 Tw T* [(\215\024\f\035\036 \020\036\030\n\036\021\017\026\006\017\017 \023\024\r\ \016\022\017 )0.5(\017\f\023\024\035\034\024\r\026\035\017 \030\026\030\036\032\036)]TJ 0 Tw (-)Tj 0.135 Tw T* (\027\017\036)Tj /Span<>> BDC ( )Tj EMC (\227 120\226100)Tj /Span<>> BDC ( )Tj EMC (\n\n \030\021.\f\021. \221\n\036\027\026 \023\024\r\016\022\017 \017)Tj /Span<>> BDC ( )Tj EMC (\n\024\027\017\021\024)Tj 0 Tw (-)Tj -0.025 Tw T* (\030\017\027\020 \n\017\022\030\024\235\035\024\030\t \r)Tj /Span<>> BDC ( )Tj EMC (\030\026\027\036 \023\030\024\r\024\007\017\035\017\f\034 \004\036\030\036\  2\2263)Tj /Span<>> BDC ( )Tj EMC (\007\027\016. )Tj 0.205 Tw 0 -1.218 TD (\203\026)Tj /Span<>> BDC ( )Tj EMC [(10-\036 )0.5(\f\031\021\022\017 \023\024\f\035\036 )0.5(\024\023\036\030\026\006\017\017 \024\021\n\036\004\036\027\024 )0.5(\024\004\017\013\036\027\017\036 )]TJ 0.082 Tw 23.244 14.614 Td (\017)Tj /Span<>> BDC ( )Tj EMC (\031\n\036\027\034\001\036\027\017\036 \030\026\n\036\030\024\r \030\026\ \027\t \r)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\017\026\027\026\035\034\027\024\005 \024\002\035\026)Tj 0 Tw (-)Tj 0.004 Tw 0 -1.218 TD (\f\021\017 \(\217\017\f.)Tj /Span<>> BDC ( )Tj EMC [(1\r\). \221\031\n\n\026\030\027\026\016 \007\035\017\021\036\035\034\027\ \024\f\021\034 )0.5(\021\036\030\026\023\017\017 \024\021\030\017)]TJ 0 Tw (-)Tj T* (\006\026\021\036\035\034\027\t\n \007\026\r\035\036\027\017\036\n \f\024\ \f\021\026\r\017\035\026 38 \007\027\036\005.)Tj 0.35 Tw T* (\203\036\f\n\024\021\030\016 \027\026)Tj /Span<>> BDC ( )Tj EMC (\023\024\035\024\032\017\021\036\035\034\027\031\033 \007\017\027\026\n\017\ \022\031 \r)Tj /Span<>> BDC ( )Tj EMC (\021\036\004\036\027\017\036 )Tj 0.466 Tw T* [(\030\026\027\036\r\024\020\024 \023\030\024\006\036\f\f\026 \f\024\f\021\ \024\016\027\017\036 )0.5(\023\026\006\017\036\027\021\026 \f\024\b\030\026\027\016)]TJ 0 Tw (-)Tj 0.063 Tw T* (\035\024\f\034 \021\016\032\036\035\t\n, \023\030\024\007\024\035\032\026\ \035\026\f\034 \235\036\002\030\017\035\034\027\026\016 \035\017\b\024\030\ \026\007\022\026 )Tj 0.145 Tw 0 -1.218 TD (\(\217\017\f.)Tj /Span<>> BDC ( )Tj EMC (2\). \200\017\030\026\032\017 \035\017\b\024\030\026\007\022\017 \f\024\023\ \030\024\r\024\032\007\026\035\017\f\034 \023\024\r\t)Tj 0 Tw (-)Tj -0.028 Tw 0 -1.218 TD (\001\036\027\017\036\n \f\036\023\021\017\004\036\f\022\017\b \n\026\030\ \022\036\030\024\r \(\023\030\036\f\036\023\f\017\027\026\) \(\217\017\f\ .)Tj /Span<>> BDC ( )Tj EMC (3\).)Tj 0.014 Tw T* (\215\030\017 \021\013\026\021\036\035\034\027\024\n \024\002\f\035\036\007\ \024\r\026\027\017\017 \007\030\031\020\017\b \024\004\026\020\024\r \017\ \027\235\036\022)Tj 0 Tw (-)Tj 0.042 Tw T* (\006\017\017 \027\036 \002\t\035\024 \r\t\016\r\035\036\027\024. \215\030\ \024\r\024\007\017\035\026\f\034 \023\024\f\035\036\007\024\r\026\021\036\ \035\034)Tj 0 Tw (-)Tj -0.036 Tw T* (\027\026\016 \220\f\022\026\035\026\006\017\016 \026\027\021\017\n\017\022\ \030\024\002\027\024\005 \021\036\030\026\023\017\017 \(\006\036\235\021\ \026\017\007\017\n/)Tj 0.248 Tw T* [(\026\r\017\002\026\022\021\026\n, \035\017\027\036\024\035\017\007, )0.5(\022\024\035\017\f\021\017\n\036\021\026\021 \027\026\021\030\017\016, \026\ \n\235\024)]TJ 0 Tw (-)Tj 0.204 Tw 0 -1.218 TD (\021\036\030\017\006\017\027 B, \007\026\023\021\024\n\017\006\017\027\)\ . \211\004\017\021\t\r\026\016 \f\024\b\030\026\027\016\033\013\031\033\f\ \016 )Tj ET q 70.866 351.385 340.158 201.575 re W n q /GS0 gs 340.1574729 0 0 201.6459197 70.8661464 351.3137764 cm /Im0 Do Q Q BT 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0 Tw 9 0 0 9 70.8661 340.5849 Tm (\022\t\217\210\b\002\220 3.)Tj 0 0 0 1 k /GS1 gs /T1_0 1 Tf ( \222\023\025\021\025\006\031\t\013\025\017 \t\023\205\006\026\017. \222\ \n\021\203\031\021\024\032\026\203\025\002 \033\032\031\t\031\033\t\025\021\ \026 \027)Tj /Span<>> BDC ( )Tj EMC (\033\n\t\023\031\n\033\031\032\026\203\025\n\021\021\n\003 \033\031\032\025\ \n\030\031)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0 -1.2 TD [(F)-16(igure 3.)]TJ 0 0 0 1 k /GS1 gs /T1_0 1 Tf [( Clinical case. Presepsin concentration in the postoperativ)13.5(e per)-37(iod)]TJ ET q 70.866 100.996 340.158 218.285 re W n q /GS0 gs 340.1574729 0 0 218.4497548 70.8661464 100.8312279 cm /Im1 Do Q Q BT 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 9 0 0 9 70.8661 90.1959 Tm (\022\t\217\210\b\002\220 4.)Tj 0 0 0 1 k /GS1 gs /T1_0 1 Tf ( \222\023\025\021\025\006\031\t\013\025\017 \t\023\205\006\026\017. \200\ \025\021\026\003\025\013\026 \202\031\003\n\202\032\026\003\003\020 \027\ )Tj /Span<>> BDC ( )Tj EMC [(\033\n\t\023\031\n\033\031\032\026)0.5(\203\025\n\021\021\n\003 \033\031\032\025\n\030\031. \222\n\023\025\006\031\ \t\024\027\n \021\031\017\024\032\n\f\025\023\n\027)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf T* [(F)-16(igure 4.)]TJ 0 0 0 1 k /GS1 gs /T1_0 1 Tf [( Clinical case. Hemog)14.2(ram dynamics in the postoperativ)13.3(e per)-37(iod. N)21(umber of neutrophils)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\033\030\031\030\213\b)-20.9(\035\231\213\233\t \021\032)50(\b)42(\032\231\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj -51.938 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 23, \023\0221)69(, 202)69(4)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 23, \023\0221)69(, 202)69(4)]TJ /T1_4 1 Tf 25 0 0 25 20.8528 56.0378 Tm (124)Tj ET endstream endobj 1199 0 obj <>stream Adobed     '$''''$25552;;;;;;;;;;   %%#(((((#,0000,7;;;7;;;;;;;;;;   %%#(((((#,0000,7;;;7;;;;;;;;;;   %%#(((((#,0000,7;;;7;;;;;;;;;;-""   w123q!6ASTar#&Qs CRb "$%'()*45789:BDEFGHIJUVWXYZcdefghijtuvwxyz  y!1AQSq"23ar4s #Bbc$%&'()*56789:CDEFGHIJRTUVWXYZdefghijtuvwxyz?@@Xv[nAZKv[˱\$ԯ]}{Ohvӱe{:]7?HܫҴ[].6Zn*1J.; otWeg8ط&^`h{ J6R g4)_v$^'c+m'NӴq#ZF+~ %vht|PQ{ Gs6VZ^)egdfXU{htmm9YMŸ2gNi6M7ֳrtTW޷שGy dH~!zǴRCi<+^ש{I$8H~!zǴRCi<+^ש{I$8H~!zǴRCi<+^ש{I$8H~!zǴRCi<+^ש{H$8H~!zǴRCi<+^ש{I$8H~!zǴRCi<+^ש{I$8H~!zǴRCi<+^ש{H$8H~!zci<yIW޽O7S,q'G(+^ש{I$8H~!zǴRCi<+^ש{I$8H~!zǴRCi<+^ש{I$8H~!zǴRCi<+^ש{H$8H~!zǴRCi<+^7S,q'G) ש~"yI=zo^,q'O) ש~"yI=zo^,q'O) ש~"yI=zo^,q'O) ש~"yI=zo^,q#O) ש~"yI=zo^,q#G) ש~"9I=zoe{I$f:~JU[m@=ot軧.1;Ťh}<}Ku- +FӴ]YXXY St|HZnOX:-tg;IUW tYvih6vѴ%e'=!R=T+܇Vs&z-4+mAҬl&>֝ۿ^-.iVЬTcvv.]UqlV=H+i"3N[桿XE' -mKk=*FܢگdwOq+oIҥa8G5+Hd7|2ۓmـ@ -:]c)翌TtwR{ZMet`,wbXZ:8[Xi6݄e4mwզ}>nJJs;m2V\UO,w;smIҠgX;'&*[}]wt! zG{ RKyJ5rU4M/fXZ;e)q*#G^w@-4 t,gm֓Ni*_@YӴY:M:oen66+/bm=M8hAIF8tSo6UnlzX ñV kmcMu1t_<Ģ'm>Rz@ @ aiZM'Y6oU`)~H-5훖ժ-La -Ӱa 8FXMa޹+ZFPr{[%*ҕmVzF pKDpr)oU7.qLmg'a&+9VR{ mðhZdiMU4RYN[Z6e+5bTi6mg>{ұtI3I4i> YӴU:of訯+bJTx+9S9Fo!e 6 /_q~%PkFmr6_ITZkG\/Ul~#e @6/_q~%PkFmr_ITZkG\/Ul~#e @6/_q~%PkFmr_ITZkG\/Ul~!e @6 /_q~%PkBmr6_ITZkG\/Ul~#e @6/_qY~%PkBmr6_IT[kLq~%PkFmr6_ITZkL=)6gͽLfwaVbLfEO?XнeGoZKGklR!DEJd]0OzM2gʃ C;KmgG^B4YʙW6KJص#e 6/_-q~#F* \mr6_HkJ\/8l~#e 6/_-q~#F* \mr_HkJ\/8l~!e 6/_-q~#F* \mr_HkJ\/8,~#e 6 /_-q~&8l~uf@ ۗܽ.JoRjIŧN(hV{6=]ܜnmF.TNhSYXJ6I1NnU;[vN[-"ۆӺσc4/**}1>lcBMGGmy3| C4;Km> #`@ {jt)z2MoU|eBM!ek)NCma'U=ӱeG\a-]\ώ>wV,s,acJV V> ݆r-wEiPz<;&9oV[?VqѬYiUlR)-Z3BKp}3ҕ+hJYʲRMv 'IaehrbTE%^{l[-/IinÁv[J놉Ѭ"z.ZN6V.}ܜQ<>n^k=-U\jQ!=?Gݛ}%mca sᬭmbTj.W-'Z8M4uDEiFckk)(Z')bHP~Sn7B \n[]sm1:iVrsaN81>@Lg M*ЄqW[8Wogk66q5Fs\yfSk0Ti44{8pq`o'C.OFvVtFN:I3ݵҬ,Xnmӭai%9ٻiةbG(1>lN ʊa6b"##rgK4JY.cǡkiXJ%IEF޳}.CU)({jS2gʃ C^L{i%6idF@g3hZ+EζEI&Y:}ȩ&єwU@==Zׄ-&[sZZ>PԱiZծ8|֕K8|8_tHҬ--ag9C{g}꒮PʃOt4HiSҴNV6*8ƴrU7Ժ:'RQai2t6sr]r@Koa=v6qi4]Gҭ#ccii7H*txⶼ>}o^{;;YGDv{`zn(+GSt\j֢eVW7rpkM./N3|U3=q;QEG;_ e*>29O%;IZK}Gx#,pmR{޴{7_ % 9 C{ JN[bpmeGKaho7(w[h:m[CD V];Ee&M+ >z gm ogxr{UZk䠒AZY9okuXV6ve5Myt8M_3H{nlR RoQk"Yx^AUٞCo>/_4**}Y}[+=61XFڞ&ih-끆02gʃ CfMyP`}4:Gv$# GGV9غg9+mg+B;(-J*`Iii-/Fmac w֪N7cr ϴcmoio ~\%΍[^ŭוzlҵZvs{`4kKMz&:foٻ+u(Y(YNt:nh,l4+Ebd-|>}r4 ӬkkK.VydK3@@_;Xh{[iQwo;͞Ang[ֵpʝ4YqMԖhl ;;BSggşoˎmw"zdgidۭ{ڏ' EI}0 z/tK;m[-jV֊:LfJ1xqJVVXiQt)qmgUܻ֚}V$YZN*-QYW*]].:vi6u}!FQvPm$>+mCsWI଒Zo&T[9τ/n~i{9OE㽒iI8F`{nvXI9Jv4%+;Im,вiӭԦqZ48m&z4"ddɨ&M_\Oy7O=%)Z(VVpiF8%.@kOZoji:WRjzѳzlt[+;9XVqj ~'+Nr'YI}@-q~'jtWBi,t==7LSqVx t\h t^og [Fn5IjqeVۡcZ8Z\-g)V$K/wۊhz-DIM)-7FrSѬҜTҜ#<5B&xy ?5B#G?ITZq,O8y ?@5B&xy ?5B#G?IThU'O52H?AUEw)sy /ګZR>MTC"8+_K ʊ^DqVC>lŽ׷i/clT#.ҔaOS"ɘ`^| C+%&idXE'cg*g$6Q,OUFŮ5B#G?ITZQ,O8y ?@5B#G?ITZQ,O8y ?@7B&8y ?@5B#G?ITZQ,O8y ?@5B#G?IT[q,O8(?IPvҴӴeMMXFx9cNڴ1<]\GӶGrmӴZSVTas#ݽѷKHA>RKEqcroָxE3T^8,0\{NcUuZgfDsX&wx=0][Y)V2ң'^]NS46MKٻyz|a#7u% \j5gGnYs)hҤt]R /X2qiFSG42|xuiigeZMC)mIK}eocQXt?EM+M4y-{;V_ZtUJՍ0SR L^[:=YqPum`e5XXl"0lfg;TSw=JJJI3J+SPS 9y@e\&~+[/HSdG?Ek9z١yQS*g"8+_ ʊa6fogn/ O&8=Po}E}#Zd#"6K!>JsUKG[ɷwEK|.Fni\7[n%)pE)Z^JҴ^+rⲅjK*Y{4mwFH,gT[m7Dt]5;)mm''OӴYY[NYGҖ{4cZ*_q{OݭWѓRNjj=\b60-ml)-_oe&OoJSc;KHiq}8ߌi>}'aiic6pҊSJ gm(:5Fy0Pܖ{Lc*Z۸ܖ{^m>K}x1󕭻;={_uk;>/D J*׿h<@ {fgXٷE5Xk ە=,U5eo6IF.Ms[wqiSSgcg}ME~1`-+Wr>p{{hvzNZDe+8;W(ʍoj z&-"saϳ#ZNO}%M쯺]/emgGHҝBr֛US}K3{a84hN9ع>9:W#x΋[6VZ6e8vVPME(W\X֑; [+=rH5zM9{YZ'M4Q{utv;I7Z&Q񛖴^C;[OICq>U/T8wj+3G]iJퟰFC.<ގFjUwYAٮ7*R&#-ӽ/Ax]I,|@=t{^m-KXw/ж/@hB~aYנtg^b7гZm> z*Ӗ-?^> z*D%[O-oOm?^[O,\iF4WX-J6w ڼ+h+iow{U>Em7ߡ7, Nirj=tohgM]*y/rc4\VvgMֻk\*[X]wR\̖[EpH7קЕE]M~J@#r,_m?^;[O,_m?^;[Onw/ж/@hB~g} i -K9y@e\ʿS3eksei|`YhB~VӃRZ?!r#lмggnzRBT6b^q#N/+Kʅtʻ}< C>^L_}E}#Zd#OV3r΍Sm~ z> z o_m?^ ~ zE% ;[OD%yagqׂmJ*SU47Utna~f`'ER,htiud>1Ӯ{ְ*Q)=LU|DnZk}Q8Pd&\{nmOJT.OQ+Gܛ=ZL-%+XVV}~eKi6{Hv0-QAU$/ȉhv?IlLx>hs%-th[FX7UEδ<󞉡=&tIYBxUTφh-)_ #Ж&iMEZJ a\o1kZEY6Prc*EgE}sH-4X0J0V} mUK=`Ba^Qmg^̶})a |˝ĥQc:Y*tE fzh<ɠ,9hպ3>UE% ;[Oo_m?^ gOo_m?^ @Opec:}v nDд] <^vՃѪJCҴD- Gt#JK9:w9e Y6w瘝:M3tLLiKIe'^{G_M_S(mlxmuUS_3w#Y]6Xm*&nb8N*ݜUU!vx2'E#=-:JhQv֔mFݝ0*;t_'EznnTm^" IVʑ9eh=,muJStܘnލeec-kN6v1pIMK3 +-4{M7s!c`Օ-7=xў KN `ZZhZ=o=a*Ep{U uÖQPy{as :% GicJWFIB]m),>A-t^yZɥU#d`x/C_^<|a(G\YF:E [} ֽ#[} ֽ'x{YF:a(G\ >5 y+[NFkǐ+w~zOO B;>IVHd}%%wx{YF:a(G\(>酦pEmJ),7FKIݝ#AV.?-D^r=ǥc,jm$ܓK3ǭ!YZh\-'NN 57XmhuʂO-^{pmwWCҜ'h4Mδ{Β<?-ha[\>mhuʂ2}6Q4[C[} ֽ&xZAYF:Xr6*taYElbgQvRyϕpd \cugrq{ټ/4<8YV1rVri Tk uw`]ǐx{YF:a(G\>;FwFǃs:79Z;>4xwfz):S#ZCZD.B_Ijtږ=,mtNDNsc;KO9芪*ŽIX)fJDVnvn7+N;u0I足ktwK\/-qW,3+ڣԥBa63ZZS36uK\ioNGZDMS'Чii&⨛[XkdtMЭ^mpE,mrKozפzO ubby0&k cֈN@@ [;+[hB׀o޹V+U]+77Pkv44^XiK}jڣcik7.S݌:pT,h4IK 黡gmk;K;$] hӬ#XY)Y}Kyobn4/tn씬)F-B-⢤txN-fմŘֹꪭ9bf^RvL6Ί몚"bnӇ|q=V]6]1UqMt>RyP||iJݜcĭ]wxFdN,[-8F+[-<9AqF*hһ9j)Q9?q*sEL]T'a[jυޭcJo-oz 6MYZvQlNq3Y)gU6<(|el^#jd=>beŒW̶[X{Z=lOlp-ocx^ =>beŒW̶[X|<''{*-fkWl)p]EUU4iٻqfⷲm'vXJ7U -읍q~]beŒW̶[X{Mu/^1SQk 1_2ma:U3QSQk 1_2ma:U2 3{lBn˧O]ˋ +nY_EK(z{ ]Wz%k =50 ߉\K 6^h湝Ln^Xvfnv gUdZ+ulZ6wjFWYmԲ[ebeŒW̶[X{Z=l%-*ۢV6xFUc ވƍ9gT_Dgm""X-9+72".q-!t1 q˼C]﷗1#6\m*W$}^.]ebvvzWc+XpIgh Yo' o֪}WDǎ-ԟ)f\GŒW̶[X8QkpRޭKMWON蒳VqZUhSkL/$ۡGFlͳ9o&[GJԽ43O~odrޕ4u"Ӵ&0vV<nrc)6QkK.XNaXMLWLgo_'*ջ ,,;[8);lrj2uw&|)#Yc£ j"ChtD_ 1_2ma'w*\' ;&pR%)XNRmLz|(|elMԉw[F+[-(|eթx^d=>bec/0lZ;:l*j"ܳH?A1VW.Q'NH`8l--m*=]qU7U1\`.,:sDS7qx{"8+_ʊa6bW.ƮOE2`]‰gF+[-<3A{džwIe%{Fj`F+[-(Ŝe"RU3QSئcL%9,s]~r/vMwgo ԼC|4 96*c(mV*Z=MK-F-0mlm޳zӉqL~ cmW#O鈦"4;n&&/,Kz/=gaz? օZ9EʮIRQnRM5ŒW̶[X@ep>l+QZx7kq~Q _ܸE.ywS{ygqd3_4lœY̶[X{Z ;1ԼDzz)ŜenceF]X`TQ61614gCc-~Ru+y4{do 1_2m`F+[-=Oz"mQk)a/"-*M6KkMۄ}oDN DEkk(8%'FdY4VF lp-੽%fs-cecceQYYk̘{r Wb1ts_D6|%xLT8ӃN euNv4% n9 ;_+D¼w{s?-ЩO[&&þ-7SFӝRl-i޺o$j>BQXϮtkݲ*,JoYv֚Emdi7YJNmFuɎ7Z}SZg:T]S'.&m}󲴕.2޺V/'/t}Ұea([$:57ԗM഍m )}i%%*.lw_OxkgcqQ,7[Ol]kgdXFmFnoSRi;io\U#Jro$Hi^h]i-G}*ϱu;XA%lahKZ2Ih0nN΍#P7SFi;~pOƍ4Y[h۱iҴ{hYX1;+w#s3)|0`>VgTuiwuKe'ʎ5iRgom˻g=,lRIZO+HoHlՋOrO-MucVN3IZE&uVڟ{ymg~ >So ٳ.r+}?a>g+~7/$SKGq|$\"Td)RsDWDJCFCJD1M9|`Df m*TY+39=S|N擥lnRN7p_̯dO^b[UdNM|$IVSwkP,t+;^cI=15151@51NҾ AwX6!Ɣl3L㲾Q7KyV{_ m-c{SSUJʠk2xSj=GѾk7%ei\^U,cr4z]!!6~\Ӱf3=^Bg}t7 g#11mpJ(|ULM7]j2kITߪw'֟HCZ~I_~CP#bDLJ:-;ZW+%oa}RH|g!oTLr"WwFX{MF/)%sC\Ro1\eiʑU鼬m8G"_#28FeEQa1S/V',Ia%4eD}+N#I51vz>emidg5'g'Hʙ>zUhiz6ZiqUI,T+*='vU2OIf8[gF^*1kK~Cw֟i5Ss *S}վazDE;VB=Ȏ70~rBUٛ={ƒ?ۋMfZ?-U^B }<C>^Lq{iCkFq[Z)gI)CJص>;{_c*/YbblBNtvzRҬ|E:YɖtK+Nb$RpJrukq,0O(=F< Ǹ܇VXvHEGE޽I*yDV)ZtEzJ3L ܴk|qt ^ܯd}ßJ1Z-Zcu"O{^ƭwf쵪: w,:w`oei(yFDJ!q& K.1n.CaleGD*{b!-+W@)7ֿT:;Yc '涘̱'{ >3i~^RZW A %hNe_)DJ!;j.P }ڗ4^{Z)ZK.w,Ihei^^K%d뒆Y-0(^^m/Z۸ܖ{^m>Jƃ=3ۺsZ5'INS+=Q{{4,i׶2DJDFDJDDc߾z]PJ݁@ {J H7^{Ѧ%GLuSplmѰUrjQߨb{rkDmˁIѣk J8t*}֟iLt{"**VRb|(Oqbqmޑagg;M{\ZQ`ikTQE:uU1.V DՃZk4U]>2P@!5svm+E4ԔSFZ64}FVmXw[IF2Sԯfhrʃ ^fyG_M_W)|0`>VgTu ܥv6#!wGt_HGf,c+:+@=o ٳ.r+}og:\Wx/LC~(|LDflnRN7pOflnRN7pzɕ+ +쯢~Ɣl3L㲾Q7KyV{_ gO4eO4[3|yhѳ W?i.ݮ+6l8|W(\7i]ݣV#5 DCd[8F zlJ#%x]?|z%wt;=A×n2xr&0eoOЫ\~ʴ^Dm8K{mMeBUv[7Gv=ܝշV&TPZJPR0[ˑ>VT{N>eDݓ|D Yd|֝>IݝCA4kKVJNm*$TTht-V6.ZZJӅʊ&s3m^0ٱܩpۉV0ٱp̴wiw(@LH?ArG4o( n2-#On`fEO?=s~/[4/**}׷k/c}< C>^Lq{kô+4ow)ZIr]!{|XX/krUIb*fwIݖr>a+ە쏸si]xH ZqZqA!tV?@r>Z Xyt!"` qG#5bN=h}n_s[H?@h, Wϡ}ro+gվԹ+H׺Ys W[nrYgW{- mUK=+i*V4a |˝ @ ZlZ7eݝiՕKevV|K=oYZ|5,t{ "Gv8;W :*VPުSഎ[Ä{j]S4HKqEk)g*U~b9zN; *N1ŨZ*j"UVz-kgdv2k=o ٳ.r+}og(sg{KƪEm]!ޓut"bZogC@@[(@oP9{?ǗANmJ%8;7e=O n/#JJqwnжLdO^b$Vnq~8Y7ud| ಴hk@Z4[jV)^C@@[o89{?Wq_EK(f]bjNl=M>^h~*U>ƕ3<'u:~,#O}4oh~+fsİXnoCUS Ww']; >Vma3T'=%6DV5k)֮$.Oq==?FÑTFJ{RlR~+^"b-Hr~70X%^~%}?|z%yc-?!q^]g6~B ~js޹(+Ѣ-]|Fg~S1~Z-m*tL#s;򙌸 *nŸT zd~>D4wKV3Fx~, e+k9?Su68}ZN 9iG"!?=['<_(WeOpN7,cTϮ,`ut WJYYYQ0yFmZTx&'s7a'r3}^z۪\4_fZ}J6ѻz|Z9c*ӨhmS6ߠLV)^CoC@o9y@e\ʿx/#S+[/ HR*/g~k%eJZFugȎ70~rBUٞDqVB1fϋݷzۍ%&mB21idgj}< C>^L{iCb,o_;k*.@ X}F2;Mtty;',t`nNad총!Z4,R3pW7->L/IGutL֍gg([|kyMJ@ճPmEQEM%G= =+)XJܛI:uCEv:MaP @2t^}Q|:-/^gTu ܥmFm.xV͟s\m3u8~6?"zg#IC?8t"`#4,frJqwn{4,frJqwnжLdO^`><fy]e} .4aewX/4ҍ^^3<#u:~,#u:~4hgG(ZxItNtxYl`BX~J }a8F+t{}Ðn zlJ#%}?|z%wt;t~L+q'v3½RK;4 ~3½MT'/"1aWI7'U3+L#$} SHqio> wV&wF>FL0No\?TDfoʖWٖn4^(I Ѽ`~g2H?AUEw)2#lмg/g"8+_ ʊaVfogn/ 2`S&x=Poo}E}#Zd#"6'[:;]Vuܥss}eyt.`,0_(=F< Ǹ܇RXvJ@]l7e3\㏤n#_s^G֨iwt֨iwPelc*\qtV?@w@~b#{d@H2ĜzS7[MfXZ=gzi~FV;k/,Cd73ث}ro+gվԹ+R!\۸ܖ{SVT,+-qW,3+ʽ} zg9u`h<@ ֙cŜxG SsR wlV;a+K.vvsVpNMҺzEs`cS*_3(wsY2ˍ3T6f3a?{bW!8Vf WYQ*rO*?5{:MZ afQ~6?"zgqm;6C"nu?0NmJ%8;7e=NmJ%r{t7e~`hI0L.q(( @fy]e} .4awX/4ҍ^okz@>̰>tp#F2fZxItLhrNGX|.Oq?wc>ݥrnvY4~rHl*ؔ>Je~ lJw[?iQ#3)xfV~UW{_?3׌ik g]{ KȌXw9!s8 BvUqvM BvUqMn|;?1p|{3}ܥ2}s~/[4/**}Ydug51?<^}S/O4/**yMط{:-go5> 0 %e5Z8EU"Ɏ7`>jQ_H־/),;X##`uܥj/ew%.no/1}|XX/krUIb"5˾8M촦ks=MnUG94$3*e쵪:w,:w`!qtV?@t"=*]1] TH3,Iǭpcnw}Ke}#i<6Cy_c>!* i}sD:WChigo۸ܖ{^m>KB¼w{ϳ=qSjJ}Lc4\g#FL@:VmiNh4ecGkg+F|4u.Ve;[=UXYۣYY*YJ*뫬Nm۫0|a 4kkLE3]Obx_>~Hb7X6xmVuM5S]w[MYvo'%,,BJ[uZ4_?|ŘNc15QLĦގIl+ڰ<2*z"lf;gVVr]o`7|T-qX~71ţYߠ؞f&ƵDΔOl&~Egf=xjwo3˃o҅|ͳ}/b j,#ߠxyk?Z,_?@+^GATYѭ8k>zy X~7*o,2{тVti&cUuDϭ0+\]p\iK (MΕ=$+8پ ӉRr͖xyk?KFjoTfŮ+^GATZogGAPZocGAX$2ǵc,(iur4aȚHl*RR4w6jM| J|dFIkۯ\ƶMx(2-v.]Ӷ̄ ZfJw<%oUa>r QҺ58ҵǒ nѱMAS6zAX9%~#pL2lhs35O*;{ =UtS~Dnkm+kGi.ӨF 1ެ Ղr]<[X]]|80ʬ,933}=q{`vaXtZ[M\JoIVҦ4ݎ#fɕd"̴txX>nBMOax6:m;Φ#R[kY[O&aa.fɿAEfkǗ@oUy{/)^Pa{`Y[MuMELr"T{+YX6J*i-qX^74Ko@ Xꦻ[9fii<Y0u#昴Ѩb+whWl^ {(Z4ݴ%rXATiu7!;\_\ bm,,iM=k99&fRKQihkߠqH^7*S%+^ǗATXdj0*뚴IӈF78uF%$:E' aDէE7i_ -g~V< #%18͔Yg,U}37%b$ƍt3YZ*<*YoG+47t2 u&)t☎V:Ou7+s,yD5g}7ΉZf]w%N${(fk(ҹ:KEg~IXH:o@͋\V</e~Y88ƶYhZ]3]sւk&6)iJe6 kǗAltw"&ŕEγ]/ahm g&2s p<&&(&f-s_JI YYq:Yz4R f_ 3!v6tETS%2SLc8^]TMT]g5MWb;exHS}bVjN2xѢ|5W櫯MfٮvV< /e~cxߠ-qH^7V< .@t-E,ﷴŶkv/Ꮶ=VBVTMMUQ2Zivv6{);+RGyGMR{tPѬtugoo{'+Y'$żku&i:U&#-N.Lnk[;+xN.z/Ub_SZF|Se9-'+)kw6+rt'H4\vEbgcem8XZi6 GxBsli%Jch򮢷F;ih8v N)(7@EJk-aiNǃ :*Ϙ *8n[JDthGMpl*ZR>K%iҥm'):\`tE,ﷴRWٕ:iiA]{@RзMnzAi>w{.!ݽcKGV2m"SSUW3Tn}<aY٥%'Z*5Em{m,,ۅ&$x|n6tݕ\cu`y'kvCG-# FUn^;}&JCGSE'Jz;Vy i86RW<.ge>C%;))YNuRXVؽ+>ooW wZv:6Z钂nm!%7N=&Zfko6۴}@sзZfi:gjvSj.qϜ;t7Q:,9)&L3mcH\W$ܓk\ϛ(I}vie.RkjhB7aʭuQ~-7J%{TŀU>swF;$CJrstMS珶܍Ǟ=6Ox{8p03jN5r]Bn~q8J.\U+eeneeF-FJv8!ig)BT]U[斷:FhtmOiVqIZ4ttni(8ɤm3qg[[)d Λz+j.y3OD-4[0JM*)֍ϝ>׆"mekxWc+57iv%ֻ|8b,* /?hFiҥ|,!g(RnT,%*VM%WE|m;qmtώYZi6HJo6j-֑wxZvJPdJ&zd7/KZZ.:4a+pJ®+3@-h44"vek>+7=kmЬc-VՄfkyZUy^Ҭui %'}c[>=ϵZ>p|FJoQu[뱹PӷDѴhwcJ͹$C[0&g9vRcvt>xցYzD,mMgzJggZ]Kxin-Fnk].? ii%+~'i<{r;`geIZoJt*|n5Yz6Ƭ'k;75g+=isx4hkkaIA&snK|>0FitBMI96Ey?t[6qh-MR-1"OMhVv-v8Nݻ-(p+X5hoe'KKKB{[JnPrJsLv]* Y3N-x h6gq!f+i99:R1_t[V ;8IZ8998:֎C=gsanemMZcVӄ="rmnHZ8t\&V|[܍+Ej'4mSO{O+ VRv6|2E[ӳIީ]Wj<Ost K.:,`⢜oj:VcijAj:Vi$iii1M)pq{ܚvc.[[%,缅޹]R ,,m یYRxu{Mtd%gf%biu+S'pmVPzt,tyIYo%6I5ʦt tKt8-*yqy)﷩oIՅ6RoI#iޕR{U܇hKtwJ2x9G~mXoS@>Ni6Uw;|e&umշ^h YV{g)i'H׾MmcHit{7g)i)eNv2ܹ9q}Һ^=2v4=Zk9[%mgg]a&U0k;)JN-;NEҞ[mu7qL@@X:fco>" 6hz<֙Zѷ9%G[>~;i4 VO,Psd{}ʎIVfƉopxXhgCЧ)BKc<,(=+63}C}niʕ ]܍D4l|7O]BT}.Jr=+G[(ƴ1;I)&҅u,a="J# dJߝX{)Yh.OvV|SV.troQW2-M-6vVmݛv:3ΕrRT=MܽG܉XKtX3J*Jrqw;ĩtk]-f֕+}hxuN.` zOnD [Dp*mJLo. 5'|;MMMI{]h^ N*5& w77n~a [F曔Y4{m.t%!)Fnլt6ZcJNƛFZo"w߫Ӭt[Ʋg`t,dڂWzVɭ5,b{K. O7@"@@D_3tsh~ OwvNaJnT2Unz\&zM|op--j Dj{4K?-j|0-'/z@m%SØ&1oEU_Ⱦf֙3344ʦCeo*S{O;%8i5f0zO^^T}q`ZMvsJ--tgΙo {G8c$ҤcYܩnFnrxVmΎ@9ZT[ZlFkTZ-CZUNӊFock*RUǹ*plZ&oQ8vu|HLh MJG{m@ѥVnl+5©l\T[ohzRJ -w[6\jm$$M_L3:n-ٞ=z}UcT֦6oqsҬWz쭒ij/R{שL3 RtK'YV2n&tsʛa\0mp:-TqEK8ۘ-u=pV7*:=oTuj{ɾ]3Mj 7~ G=;,#UiM6%6tLڨ=:N K|ʡrIwE^?I$#MN wuKÄIŦj5GueoYV4m ݬI4K]Kދ=6JRm8/=w>@xTi,Ov^to]5黭'kkBeJ =:D,t *B%6o;xEBW̕䪢&aBRtI*B{pZPINzcDgе+m#H{%MJY:U{؀s,S\(M[kCKѭ:V~YIizjw]e G\XV:NY[8hrӣ :%'Y(6SBusc:eek}.Oa@>#y:o71t [ "o-⑎{7Qz$%YJb۸oҳިc _umUEx{t{hgf*Hm4k5jP\]|w-.Ks%OB^ ˄+Fh.Y|ZHLh;U-Uރ6Nxn'5 &oeUNk]+CܙBj6{pIp'޽OtVsi:V-EѭV[iY\󴒍~-":.Ӷ)ŢagzBrj+ Z&Ow7WNTUg@pk 2¼ -,")7%gwFrk& 8O2puW3|Y96~; d0w]5 CU2 va]w0<,ʋSerm&LKN\S$i|dnktwOH+{[{Y5|l%-!i8-QKCHQɪ-뼴wί{&IMջ޷4 6RivbV֒uuw#|/|歹6۫x,%A ݮ-98Ѵ( լ-Mm-"mJVrmfD/iYPN{+-&Gxg7JjH@oMaCFvq7'*(ZY69A\[OI;k[Nr L 6-IȀNrm:ɻ󙍽QS)5Z"ou9[Z'5Rmu xŶyOyJow{Nc^wvNE{W1EwcIDnMZ:Hn6jMUJM9NMTܛuF7'wduWui7Jɺ:s֍[rmVo@ endstream endobj 1200 0 obj <>stream Adobed     '$''''$25552;;;;;;;;;;   %%#(((((#,0000,7;;;7;;;;;;;;;;   %%#(((((#,0000,7;;;7;;;;;;;;;;   %%#(((((#,0000,7;;;7;;;;;;;;;;-""  9UT!"15qt #$%&'()*2346789:ABCDEFGHIJQRSUVWXYZabcdefghijrsuvwxyz!1AQaq"ST 2 #$%&'()*3456789:BCDEFGHIJRUVWXYZbcdefghijrstuvwxyz?0tBNcCFѰ=ԥ%]X)EwO/@$9j8Jqp[`}%zN.>iƭERJ2tt8Ъ0IAz#$)IvژڔMŬZ2Ϣz>zTe hнDNIIӍ'ZV4p%)9rJi6]F辈iGK bNu޲T3=9G],UKǗ-tKǗtKǗ-tKǗtKǗ-tKǗtKǗ-tKǗtKǗ-tKǗtKǗ-KǗtKǗ-tKǗtKǗ-tKǗtKǗ-KǗ0=/^r0=/^q0=/^r0=/^q0=/^r0=/^q0=/^r0=/^q0=/^r0=/^q0=/^r0=/^q0=/^r0=/^q0=/^r0=/^q0=/^r0=/^sH|yyʀH|yyH|yyʠH|yyH|yyʠH|yyH|yyʠH|yyH|yyʠH|yyH|yyʠH|yyH|yyʠH|yyH|yyʠH|yyH|yyʠH|yy#* ]##* ]##* ]##* ]##* ]##* ]##* ]##* ]##* ]##* ]##* ]##* 1eʰ6Ѫ0Ҫ0EŽ>>LHEςIAZކNPt7SHKUѸI揎t@/CD֏IUQUy*܋EޏjJ>nw0,OiG98&*0Kuj2Oj \M+ 4Ce-Y$r3D0pq1傞Nr&StQy4_>?RZF/ `#PrJm;U~ h~ Z'}䆦gk wHjh~ Z'}䆦gk wHjh~ Z'}䆦gk wHjh~ Z'}䆦gk wHjh~ Z'}䆦gk wHjh~ Z'}䆦gk wHjh~ Z'}䆦gk wHjh~ Z'}䆦gk wHjh~ Z'}䆦gk wHjh~ Z'}䆦gk wHjh~ Z'}䆦gk wHjh~ Z'}䆦gk wHjh~ Z'}䆦gk wHjh~ Z'}䆦gk wHjh~ Z'}䆦gk wHjh~ Z'}䆦gk wHjh~ Z'}䆦gk wHjh~ Z'}䆦gk wHjh~w}eiވ8[x(aR%ڬ"hwHzhf.8oDҵƃx4TNqjڥI^z^\l\yOg (J3j-7|f>?<4)Ǻu$դމb6-i{:llL IQ) Ţxz.K.+m [ qt)bKJ*)NMF6Jr܈=*1MKcQF"-WU]S-STRBFzHB: # xxgJ5t"*$!KηЭS^ )Ԫ0:,a89bKWVr{y]h|׮nQ-ժ0;^ވ辇i3('e[ѧCO'8xiF2TI;3Zn p>E*\`ϏRɶz'3ĔtLM mZ| 'Jo=H%vJ3VKcbzO IRƍᆦ6.y{FSBtXoN'i!-tl/LC/0^^bѰ1ãazb yF<x%* ] K:6!-tl/LC/0^^bѰ1ãazb yF<x%* ] K:6!-tl/LC/0^^bѰ1ãazb yF<x%* ] K:6!-tl/LC/0^^bѰ1ãazb yF<x%* ] K:6!-tl/LC/0^^bѰ1ãazb yF<x%* ] K:6!-tl/LC/0^^bѰ1ãazb yF<x%* ] K:6!-tl/LC/0^^bѰ1ãazb yF<x%* ] K:6!-tl/LC/0^^bѰ1ãazb yF<x%* ] K:6!-tl/LC/0^^b=*dZE?mUfͥUZnO"gly3eJە1B0>ťV<P%Ty&OHu^DyĂj֪0'4w:<]%&NrQO@OKF xŃIU-[o?iAf =/H4MZ Ο.6)~'jiiIoؚf&p:UզmmҪMMթXUYo&l[&r,fqj6^ѾA4=S#ol{G˭_Z}u\[=@ת0'14}# kbaPTnJѱ$fʱi>b:L'胔%і,WU7i| mw>>8ތ4C1q\=YVUPxqܳ>Us;hKl8ҶxxK (NSzn+;z=`F bu (>ڋ@,wh::С+XILY⏔mqku)jihdaFl\rfyQrtJWÖ,`'=0108ʕ{-n;cu^5KѱW"\ ѱW=ﳗ*9pˏm9wQޟOk.(tl~?@{ʆ\<[m]w-.;ˊO~c9p򡳗*<cuKm˺&FS_\ ѱW=ﳗ*9pˏm;wQޟOk.(tl~?@{ʆ\<[m]w-.;ˊO~c9p򡳗*<cuKm˺&FS_\ ѱW=ﳗ*9pˏm;wQޟOk.(tl~?@{ʆ\<[mw-.;ˊO~c9p򡳗*<cuKm˺&FS_\ ѱW=ﳗ*9pˏm9wQޟOk.(tl~?@{ʆ\<[m]w-.;ˊO~c9p򡳗*<cuKm˺&FS_\ ѱW=ﳗ*9pˏm9wQޟOk.(tl~?@{ʆ\<[m]w-.;ˊO~c9p򡳗*<cuKm˺&FS_\ ѱW=ﳗ*9pˏm9wQޟOk.(tl~?@{ʆ\<[m]w-.;ˊO~c9p򡳗*<cuKm˺&FS_\ ѱW=ﳗ*9pˏm9wQޟOk.(tl~?@{ʆ\<[m]w-.;ˊO~c9p򡳗*<cuKm˺&FS_\ ѱW=ﳗ*9pˏm;wQޟOk.(tl~?@{ʆ\<[mw-.;ˊO~c9p򡳗*<cuKm˺&FS_\ ѱW=ﳗ*9pˏm9wQޟOk.(tl~?@{ʆ\<[m]w-.;ˊO~c9p򡳗*<cuKm˺&FS_\ ETe2XqpĒQ1Dh:6'<,UFp%6##jw\OYi:T r)hzÆ'lZM)kRiݦ=1z8ChVn6&FZ4tOC9hO85diů*.iZfGDѡciE:R~:&XZdc yJ8jZԊUuJ<գWU<5|E_WU<5|E_WU<5|E_WU<5|E_WU<5|E_WU<5|E_WU<5|E_WU<5|E_WU<5|E_WU<5|E_WU<5|E_WU<5|E_WU<5|E_WU<5|E_WU<5|E_WU<5|E_WU<5|E_WU<5|E_WU<ҪSRÚc3cVUQ4O&lU'r,fqʪQخ W?nUm)^o8_!|{Q6)@Ѫ0$$!$#T}ݩMȌFǞ!8j  /F5'_n%ݢkNt37CD:ttVrG眚_5UkFg 6mx=,nin&h6#$千9kŽEuhۉBJeFZRxQ֦rqm. Kp}7G_Cp1pގK3=HG:Iҭ7JR/Fx"tL\Jaxx1sE,@GI o}[sdc^i~^JQ#k'UZ*M%W:?m;Ex.8Ўw.iɤӮziޅ鞇,9i8O8ڒ֌lڵ@(Ӫ6OKչXU]Xlꍓno938eUWV(Wt]+*|_!|{Q_!|{Q6)@Ҫ0,8ҴyVPi8]I5ܫX\tN-' 65Uo}=FVZv'\q,-X2SSN+v4M"2Mald]OIt&q:4kHr}ۍ+ YRphZ|#EVCFpPMsII;+zh/N$xvP4EW[UUGNRYŦz_~>'Kp=W)7%^抜oj- >``G /Ia bEG wM^e+G#C!7k8NLժI+5\LQ>a髄RjIttLODtCc^hxV[>G0p{;J_sJ:Gm8n^*{<_SmFwt^` ^a^` ^a^` ^a^` ^a^` ^a T~<:~<T~<:~<T~<:~<T~<:~<T~<:~<T~<:~<T~<:~<T~<:~<T~<:~<T~<:~<T~<:~<T~<:~y*O{yO{y*O@ l4yxJC.R7J"O{y^zx.3$bMf I2~0i+  b3MjJ1Tj:%- I',hFR%mi=I<訳:66bb.3'-L(,[Ik7ʅ /D&'HRqd(^L&ѽp%tAʸj7[I8B8zDDI<i9M:on0w>گ O8s& xxqXJ-N)ƺUٜG}ѧ-ak1Ssj |-t'yt'y-t'yt'y-t'yt'?U""U"^` ^a^` ^a^` ^a^` ^a^` ^a T~<:~y*O{yO{y*O{yO{yN=/Vc3UUbų6OKչXU]X]At~ܫlAa/ny_}tN)ΩVˏQ4a7ܢeGۀZ &,^])^Ӫ0;ރiIXsxq[)z"uj8$&Ǥ`6R-jS@4<_D 'DcPmL=# H“J$SqD޷XWAqz4=H%)aQWjoʎNUӨ2jڲ*yjj11Q@ -͢ZRb*ͬ R^kEx<]lP1q9ޝQDrQI+$g6WꊴT)#=Q4KŚ^IVO`0hԲ#1sTϛ=tI~×\>WIDMIt+]a$cd1w8/^-H9:DxVi$ŀ ;_k6"$!Tlsyȱ*Gb'r,fqʪQخ W?nU?=>C%+ܾ >^/r >F"Ԫ0'a%U'T <Ӫ[5MNZ,}t7K3*,5w{{tuT,Ea% &8-'qPeGs>tKƎaGi(nXUQc{+G菡OFĔeU G/&?Z&>ipcNQM\UG0;.l- -͢WTz튺ljun;[<w.mh6"%zNb(_9}e3x udʶVo#bLoef-~4ߏ돷@}/m2O!M e0]'o:ye-#e]/</KD ꍓno938eU_V([:d[E>UWՊ?;Jʸ>Ǿ}|{Qh<62e[rf6LmdʶVo"ߡ!0,x\}-w/SG&&0z%+EQ|W$raDY&鏽az1/SEPk>htްM@z4UcX^L} TZ鏽az1/SEPk>htްM@z4UcX^L} TZ鏽az1/SEPk>htްM@z4UcX^L} TZ鏽az1/SEPk>htްM@z4UcX^L} TZ鏽az1/SEPk>htްM@z4UcX^L} Tgit{`v~vI״ yt~ĵz4xצ6+J[ߜ8_aDIz4:cX^L} 鏽az* ]1/SC>h-tްMz4:cX^L} 鏽az* ]1/SC>h-tްMz4:cX^L} 鏽az* 6~OƝuajUI$L} 鏽az,z'T,qchLII5$i,zMBZ^ ұc75=g[lz4:cX^z3jnN[tUg3 xT,(5>htްM@z4UTlsȱ*Gb'r,fqʪQخ W?nU?.CKrV VJ <Ȱq^$c*6Y2×LF iK_  X٩}:{q)i&6OFƎ6eեחiдF=3 AѴxBJV K 7Mc0pTk*^i6L|<8 E?~ZvmTg藡Zg^OC=%xO0uÌFu+c::NlGxY*:Vʮ9..-:qJNm+Z迡ނ= .kF41~aJXo\GODt;DF q"IbI$U֥k@ gzF'i ]偉J+,5UeϡW~tbMO^M*CU <;x.shid*y&$/Z!.螂†4,Y^Q]mKV* ΉUk/B{Nzhbz&.Gў>~m&%EGw)b|]O^Nm5$[j=:d[E>UWՊ?;Ψ=/Vc3UUbwGҾr7a/nǹ}m!a/ny_} E0ת0'6/HX;Xm)֥9TERx*8k[HS U"ҽӱt7Bд]#pټ78j9IVeMgL}wI=4|gFÒփrf۫o.@t=JBn. VE]qpq01% C2$ԓ;^2xuib:,%*֜j=/G$hI:Q^Oszh8qtl\MJpqUΕ{'N~z2r=Ɩm<<6ږ%~_ygLϘ 6r˪l6rg lyh{b]kۃ0Z߫[e+^kA}Q/zu>QrQE+%F<Dk#/>pLoef6Lmdʶ&[;&R%ߏ2돷ERO!I "zla֗_x %r΁t/GۢÅV9%_)/>r\ mFxxSE^@Kn'0q'mQѶԵAވ.-# %Z΍JgsC%F=Z$#(&ͶWÈ`h K 4,(Ԧܷ.hE>5S†,,XA*QU:{SG  I<${~Ɲz-VIc,m& I:s3GGJұ^66$j.`X-|AG> # _|q|>8*_|/>p 8PZ|AGT #|q|U>8>8*_G_|Ak/#/>p T*jEYcSh J]h8F9 pxaVofzq*edȴgBM,ZJSkU9=Yu{/'-ISijky^<!)-z> # _|q|>8U>8_|Ak/#/>p 8PYD5Dі0P4qt<*L<)8*E#xtt]lVXv6&5YΉ\ZJ # _|q||q|U>8_|Ak/>q8PZ-|AG> # _|q|>8U>8_@*_G_|5Pךz2QMIt eT-isz%:Db_1_PŠmײd{J1nR^'|!=>]ko@T,_G_|Ak/>q8PZꍓno938eU_V([:d[E>UUՊ?;Jʸ>_!|{Q,âkUk*UFR[]jkGߔhpD|;էԭ{@Ъ0&ў6xċԋqr]j鼪BXСC {UUՊ?;J>Ǿ}_}}_} EѪ0=NQrJ*7m Fm h+ZTU}k\D-="8\RUkgUπydh~:WKAtM:8z<# Y֪xw#=us=a7J)NզMQ=dM'830.l- -͢WTz튺ljun;[<w.mh6"%zNb(_9}e3x mdʶVo#dYLoef-~4ߏ돷@}/m2O!M e0`g[Pf8(2ڇ7]3ܓm7>9"2g薗ac(&*J% }=&\\㋆$WS\]3M^$ucVI*$cLӽ7Uj:D#EB*1J(Cz=:*%⡣ʕZUMUl Թo6m@uMf_+*=R]?ĺ׷=y(Fd{쨵>pu^rf֧؊> QDrQE+%YZ*wa*r~a񟘬<62e[rf6LmdʶVo"ߡ!0,M.t[苿xzbaR]W˥rO!M enâ.?1TrA9#xٮ  $WM4}k.?1(lh+fW%x}~DLT_s?1z#ir”pqSRuqvtq^oxxzhZf6Qu0hMZj%h:&臠؞a[Ie熜gF:gDr>:2$$tigv= =68N=ږ,YU'J=z 莕bkJMkJ%l9`D] ~a񟘪-tEgw/D] ~bƇL# FxQyөoz.]*siU6$::O掴m#DtI8іâRR_@ HҴ.:6NxsctTp=}-+,\<,K_XsUK: G=JabRug fw`1v| i0Ɔ'E9FG)zixZ6k(/;)kIҚs:#Mr; , h:0e9-mlE 5Fv+KG&迡zS1th|I;-fnh7ItcBV<%RzВrZֺ\JXzN> ETI9κ[m{GIoCp=bz%(hԖ&;J$hމz`HX8Ĕp,4՚߽zi%7=> EZI4p)a֞rM~ݛ V|/D] ~bsC}tL&MiY$ro&=z"^3OK#ExfOGXxXrZԜi)V.:>D:x8&.cKFŎvPXŒ֢Un}@"^3SKC7Ic,,˺4_?ߺO؉4`-tEg"P&VkY,D{o D] ~a񟘪CO=0t;?;KZG<ʺ^x?cbZ苿xz|>^~gW&'D] ~b| q,\\JjšV[c7``z>aX1ėc&\Q` ;, LѴcҔ5(F.)eur]wGibJoVR\5Rt["4X:>&>& 9R9G;EKEO@;Gz^Ɔ.ZXS÷ujg=e+a8~z6Zڷ)GY>xtM,] NK IÖoVRdⵒ|ϩSH+K=0qt:'X*1qiJ|&薓CG֢QN)5ɺ*Egw/D] ~a񟘪-tEgw/D] ~a񟘪-tEgw/D] ~a񟘪-tEgw/0Vl yM|i`G*i?*_1g!IZ0rtG&C%+ܾHxĆT֌]QӪ0l To6m@uMf_+*=R]?ĺ׷˭;[6G=GA}Q/Qyu<62e[{+7c&Uy TIdolju۠I>×'ː^&20vk-szF]mC/zIbhpKr"XqDF}g%eVESTУx$11B kg8I3zECp㋤(*KU٪UquW@.z^zd< pJR$ZOSI,ѤĤ  \{K,viXׂ=11#k$#' H4(4M3NSnRmmݶ^1%sP#܈K\j+ t2ƂjZXifAca{b}`n%>~ݛ g_sO3MHǪ‹fq ZrN@<< C= p#=+J1Ä%&һo#іz =/ .,5N5[|lM8S$]c87'ɢ0tiq! h:thGV󊢳諙*gwT攍P.ґ~?b$T=6>=c g0t;?;KCO=νe}̫6 |Oxhk]Md՞xQhAYI Q$–*ˑ}G#^t]d:F.(9Pa+J/GC$r(K4 #=ކz覑j 0?~ DLcN,,lbM+tqo$JU >'FƔ#AHgFI5gTIz|='Iaac<<8nr""l- z Mb85Vݛ'x5ei0+6ZRM`q}0ÔqNm'?^A? I,.`ziP`hظuk_ sVwI I,k'=@A? /? ]+Op.*xx3],hA? =JT[hzL:xBOV\"O'g~{c,>+ HJYё{k' YciSamWS.rgдc`b&4%6E3@Iah~0)FUWQqci?i:GHRń┒ ןOA? %M#L.7,,H HVN^_A?O'd6iKFqIaBSyWU:x(RrQnZ5s ]y,m'8KN2N2iŪ4iz{k'ci?h6|LwV)Tōu JkU)UQA? I,󋅉9aBXs4$4@}~xחOKhzN'QUk KQLt|Y``bbbºpÔ O'ci?c,xSIbETy:4~5}AҴnMmJ]Ty4nj:Kg)z~5GgÞҮ$\%GɤȀ=v Y6ZfFԦSrt=p4M#IxX88%)*gd-&g(bEqtddӺ=֪0>GLnj3 =*rIVQiVTZoG@gM225:ռ,9UF8FVI,|IbNmX )%؈ ;FN.FXpkgZUt?F a`b2r&'[<=)jd]9,IJsrmy}?F薏z=#GXؑ&RrǒrUN;膋mHAIAA*U\ɠ ZV\|\ 4僉86n ׀f{L`O FNj-IcK2aeѥFm`ONPI^QTMVʴxؓnS&ۓl}~N |]EҤ0+RNKv>>$q1pc'.(,uWbHб1%9JRwnR[g ?э78:V$q5iTI8E:*Dұ,hcIC 2qR+I&Á~qbB[ xR%%fsiz> q5{Iڎ7XzD®]ik*ZOEhҜ4}/OHk;5U'ʗtE4D# :1sjQ^J't] -G 2qRI&z5/jMRhxKҦny:>&/l)z&MD4D'n1ՊcR]Hм7JZ.)2PqNͯU*}捃1S>Xm)[9aHV|螕d=a#:暚jwm:cF.J *2]iX[@tM;IxQTČVm4f)oMCIBQXcbWb*u=;.,:KJN8qMED._xpӖT5N4g3@[L28ѱ#xpRQ58Ǖ辙%iqPQqSÅM:($P l49`[G0S딪#Gtg蘒XxI #[8ޏXz%-|HCJ! *1֚xj)ƱtsEtC*ѱ4Tf&V=ף:bzEp:ߺJv}}#Ĝ\1Sm=Z>TFIb;V[%KrVEpz^qt`m#% I'%iC/BSU*,mVtQ|ƅ趙|%%%':SY)I:oC}7GgDebʵV@ލ߲_-iv?8m"JxQB(ePV cb0sti$UGomTLX`iXxXU2xzM^yн='%':ɥ8'az5bc,g) G,J-X;I֎CN-FiVQʺ,zv&а'lHzԇu]M/Ji3Æ$k'$=X$qPś(xz")S;%s@z`hұtPrYVJes]'} Jz6.}KV V2URM>[BcM>FzÆ"S5QCэ7GƎ".,<\8cI]kIi)-Yiթ5JXƜ1&)շͲ ת0 t \XE.r@7DちzKqf\|/>=~*͟i8k`z;JƎ?8P0#(GhJRx{DLv<<'balp$]'68([{|8IMtl]*ZN>ab=(A[WWA+ECO:Dގ',Ya%4(kR^:F>sҴY&ᇆڗq OY;S[?~cNp0v/xI`@w}ptLM;I (a,TDlv'~xziQqÎ#֜,@{J'8XӞiR*#=i7Mc=^.GXXZf6$'#,8k:^MFz'Lt !`K JRsrI|ѱ,]/B'|l8cG ab3%*ŵK%4%m~hC3=6*NZaMfzWī=-hUVЪ0=ptl,\DyavpIJRՎm{mU'g zcJ7x;&Q$1Oq[ړ@:& R2IbjT6ޏ_[<DaJ8n<\a%=Xqya&Tr/j>8PV$տ=/:ѴcB1g)j\(>l}N'.=3Iœt=+;6z}v)az!hzWB3xک(M-iD=t}#C4X=#i8sR0Ì'bݒ~EKhџB4DiRSC ac寒s=#vб0ث1@{Uh~㍦iŕ+ ?P1Oe xC]W~q(1lܴx(x_| pyP{k^* gpCE$G1X9w1ؼz藢1q(c?j*ܪNqtl]i-J'*F•JQoqѴEL<]3KNSm)FQrxOA} pNxtzպ6OgLd㉅SY7QMQ+UC LxrhZ6&vXؒvoZԸƃ@= O:fZT11#9熤dDs1ߡX:{#Z&<.$c*k(*VI4E0l=~i} ,l])9m)/]*ҵyd[= -+``z !,G&֌蚿%ņ$ JI9)V}l=iރ)|SnrņPyqRh^z ^ߡ&64 e(A,SW;VZ>Kpt<"VV|^Y1 9:?!'?*QTjkLoA4͌N-8zؘQu=IX:ZV9`KJ EiFQv]pڃB)N8xl(ǸīUWCҚ43FYOdg:Uw"=G}qVYq&ؿ@=o7\xc⾸H[ǽZCYqzf|QljhY4A\%Q1f!,1qyNMeJپ(Lt].ĎXnJqI7֏WހwF# -#z`i{L4i$^WwܕTWw KGћ0 :*-VU`,4LoD15!<< + IZ<$nJgi>z)<,-#D,iI=]h H>w@tCÌH\,~ZֶU(Cwഭ#[UJ:ыor0}?~*% <.t!YNM&C{JP6\'ci[Z& [|`>EЭ7LаBX.t 7<9ڽoqz448bhIc;X6Loi C14J:D4(E|i^n)ʙN#@=Bұ0axpp,'\XUI:Q|XҪ0zmCSWjC(\Y1G#JRq_!~r xkQƔn#a=bh9 My8~3?#D.C잻En9p~r0q,XK.2! ÐDHZ4mog%VT\egɖtG4:40Z+)8^scT RB0%<E? ѽ4HG%*:B֊AQIwsGэ7i_Jm&Öh$.D4G𧫇9Q-ml&j*晥gMxXxP, )&oyb,%%%8`$rU9@ }+[-c=UtkZq6?axqxpaI(iU*8P1q7Je ER2jzn7I]_[ߑնZR(UG xo `G0„0RoQ*U֛a`bjGHxUV#uVG4tFD00|M0p<,(aJY,LF4<05>stream endstream endobj 1202 0 obj <>stream endstream endobj 1196 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\255\220\013\202\001\025\006)-9.9(\026\220\n\013 \220\022\007\016\017\016\001\220\016 \006)-10(\007\025\217\001\020\207 \225\025\002\024 \025\006)-10(\026\002\025\202)10(\025 \221\013\002\013\221\002\025\n)-10(\026\220\026)11(\013 )]TJ 0 -1 TD [(\215\022\221\013\227\220\016\001\026)11.1(\025\r \006\022\025\221\215)21(\207\025\007\016\r\020\024\220 \222\013\f\025\007\016\r\013\001\220\205\024\ \220 \006\220\006)-10(\026)11(\016\024\020 \n\002\025\r\220)]TJ 40.547 1 Td [(Diagnostics and tr)31(eatment of complicated perianal )]TJ 0.208 -1 Td [(abscess in patients with h)11(ematologic malignancies)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0.008 Tw 10 0 0 10 42.5197 724.8299 Tm (\023\035\026\f\021\017\022\026 \023\030\024\n\036\032\027\024\f\021\017)Tj /Span<>> BDC ( )Tj EMC (\227 1, \026\022\030\t\021\017\036 \f\017\020\n\024\f\021\024\n\t)Tj /Span<>> BDC ( )Tj EMC (\227 )Tj 0 Tw 0 -1.218 TD (2 \(\230\026\002\035.)Tj /Span<>> BDC ( )Tj EMC (4\).)Tj 0.012 Tc 0.914 Tw T* [(\215\024\f\035\036 \022\031\023\017\030\024\r\026\027\017\016 \017\027\235\ \036\022\006\017\024\027\027\024\020\024 \023\030\024\006\036\f\f\026)12( )]TJ 0.391 Tw T* (\b\017\n\017\024\021\036\030\026\023\017\016 \(\216\230\) \002\t\035\026\ \023\030\024\007\024\035\032\036\027\026 4 \023\026\006\017\036\027)Tj 0 Tc 0 Tw (-)Tj 0.012 Tc 0.272 Tw T* (\021\026\n, \017)Tj /Span<>> BDC ( )Tj EMC (\027\017\b \031)Tj /Span<>> BDC ( )Tj EMC [(\007\r\024\017\b \023\030\024\r\036\007\036\027\t \022\031\030\f\t \017\027\ \007\031\022\006\017\017,)12( )]TJ 0.323 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC [(\030\036\031\035\034\021\026\021\036 \022\024\021\024\030\t\b \002\t\035\ \026 \007\024\f\021\017\020\027\031\021\026 \030\036\n\017\f\f\017\016)11.9( )]TJ 0.085 Tw 0 -1.218 TD (\024\f\021\030\024\020\024 \035\036\005\022\024\026, \r)Tj /Span<>> BDC ( )Tj EMC [(1 \f\035\031\004\026\036 )0.5(\r\t\023\024\035\027\036\027\026 \026\035\035\024\020\036\027\027\026\016\ )12( )]TJ 0.376 Tw 0 -1.218 TD [(\021\030\026\027\f\023\035\026\027\021\026\006\017\016 \f\021\r\024\035\024\ \r\t\b \022\030\024\r\036\021\r\024\030\027\t\b \022\035\036\021\024\022\ .)12( )]TJ 0.18 Tw T* (\025\031\030\f\t \216\230 \027\026\004\017\027\026\035\017 \023\030\017)Tj /Span<>> BDC ( )Tj EMC [(\027\026\035\017\004\017\017 \024\021\022\030\t\021\024\005 \004\017\f\021\ \024\005)12( )]TJ 0.274 Tw T* (\030\026\027\t, \027\026)Tj /Span<>> BDC ( )Tj EMC [(\235\024\027\036 \026\027\021\017\002\026\022\021\036\030\017\026\035\034\ \027\024\005 \021\036\030\026\023\017\017. \221\030\024\022)12( )]TJ 0.133 Tw T* (\027\026\002\035\033\007\036\027\017\016 \f\024\f\021\026\r\017\035, \r)Tj /Span<>> BDC ( )Tj EMC [(\f\030\036\007\027\036\n, 272,4 \007\027\016 \(\024\021 50)12( )]TJ 0.172 Tw T* (\007\024)Tj /Span<>> BDC ( )Tj EMC (719)Tj /Span<>> BDC ( )Tj EMC (\007\027\036\005\). \211\n\036\030\035\017 \007\r\024\036 \023\026\006\017\ \036\027\021\024\r \r)Tj /Span<>> BDC ( )Tj EMC [(\f\030\024\022\017 50)12( )]TJ -0.014 Tw 0 -1.218 TD (\017)Tj /Span<>> BDC ( )Tj EMC [(215 \007\027\036\005 \023\024\f\035\036 \024\023\036\030\026\006\017\017\ \024\021 \023\030\017\004\017\027, \027\036 \f\r\016\026\027\027\t\b)12( )]TJ 0 Tw 0 -1.218 TD (\f)Tj /Span<>> BDC ( )Tj EMC (\023\026\030\026\023\030\024\022\021\017\021\024\n.)Tj /T1_2 1 Tf 0 Tc 0.023 Tw 0 -2.436 TD (\021\035\034\025\034\030\036\255\021\034\023 \255\035\223\030\032\023)Tj /T1_1 1 Tf 0.034 Tw 0 -1.218 TD (\215\026\006\017\036\027\021 \202., 33 \020\024\007\026. \212\017\026\020\ \027\024: \230-\022\035\036\021\024\004\027\026\016 \035\017\n\235\024\n\ \026/)Tj -0.02 Tw T* (\035\036\005\022\024 \017)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\034\001\017\b \020\030\026\027\031\035\016\030\027\t\b \035\ \017\n\235\024\006\017\021\024\r. \203\026\004\026\035\024 )Tj 0.151 Tw T* (\026\002\024\035\036\r\026\027\017\016 \r)Tj /Span<>> BDC ( )Tj EMC (2019 \020\024\007\031, \022\024\020\007\026 \r)Tj /Span<>> BDC ( )Tj EMC (\020\036\n\024\020\030\026\n\n\036 \002\t\035\026 )Tj 0.223 Tw T* (\r\t\016\r\035\036\027\026 \023\026\027\006\017\021\024\023\036\027\017\016\ . \200)Tj /Span<>> BDC ( )Tj EMC (\205\206\207\211 \253\203\204\222\037 \020\036\n\026\021\024\035\024)Tj 0 Tw (-)Tj 0.171 Tw T* (\020\017\017\273 \204\017\027\007\030\026\r\026 \217\024\f\f\017\017 \027\ \026)Tj /Span<>> BDC ( )Tj EMC (\024\f\027\024\r\026\027\017\017 \020\017\f\021\024\035\024\020\017\004\036\ )Tj 0 Tw (-)Tj 0.021 Tw T* (\f\022\024\020\024 \017\f\f\035\036\007\024\r\026\027\017\016 \022\024\f\ \021\027\024\020\024 \n\024\020\026 \017)Tj /Span<>> BDC ( )Tj EMC (\f\036\035\036\036\027\022\017 \(\r\t)Tj 0 Tw (-)Tj 0.084 Tw T* (\023\024\035\027\036\027\026 \007\017\026\020\027\024\f\021\017\004\036\f\ \022\026\016 \f\023\035\036\027\220\022\021\024\n\017\016\) \031\f\021\026\ \027\024\r\035\036\027 )Tj 0.158 Tw T* [(\007\017\026\020\027\024 \230-\022\035\036\021\024\004\027\024\005 )0.5(\035\017\n\235\024\n\t/\035\036\005\022\024\026 \017)]TJ /Span<>> BDC ( )Tj EMC (\002\024\035\034\001\017\b )Tj 0.168 Tw T* (\020\030\026\027\031\035\016\030\027\t\b \035\017\n\235\024\006\017\021\024\ \r \(CD3+, CD4\257, CD8+, CD5\257\). )Tj 0.141 Tw T* [(\215\030\024\r\024\007\017\035\026\f\034 \f\023\036\006\017\235\017\004\036\ \f\022\026\016 )0.5(\021\036\030\026\023\017\016, )0.5(\022\024\021\024\030\026\016 \002\t\035\026 )]TJ 0.131 Tw T* (\024\021\n\036\027\036\027\026 \r)Tj /Span<>> BDC ( )Tj EMC (\f\036\027\021\016\002\030\036 2021 \020. \212\026\035\036\036)Tj /Span<>> BDC ( )Tj EMC (\227 \023\030\024\r\024\007\017\035\024\f\034 )Tj 0 Tw T* (\007\017\027\026\n\017\004\036\f\022\024\036 \027\026\002\035\033\007\036\ \027\017\036.)Tj -0.001 Tw T* [(\200 \235\036\r\030\026\035\036 2022 \020\024\007\026 \023\026\006\017\036\ \027\021 \020\024\f\023\017\021\026\035\017\017\030\024\r\026\027 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC (\020\024)Tj 0 Tw (-)Tj 0.288 Tw T* (\030\024\007\f\022\031\033 \002\024\035\034\027\017\006\031 \020.)Tj /Span<>> BDC ( )Tj EMC (\204\024\f\022\r\t \f)Tj /Span<>> BDC ( )Tj EMC (\007\017\026\020\027\024\024\n \024\f\021\030\t\005 )Tj 0.079 Tw 23.244 35.316 Td (\023\026\030\026\023\030\024\022\021\017\021, \020\007\036 \002\t\035\026\ \r\t\023\024\035\027\036\027\026 \f\030\024\004\027\026\016 \024\023\036\ \030\026\006\017\016 )Tj 0.191 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\024\002\255\036\n\036 \007\030\036\027\017\030\024\r\026\027\017\016 \023\ \026\030\026\030\036\022\021\026\035\034\027\024\020\024 \026\002\f\006\036\ \f\f\026. )Tj 0.115 Tw T* (\200)Tj /Span<>> BDC ( )Tj EMC (\023\024\f\035\036\024\023\036\030\026\006\017\024\027\027\024\n \023\036\ \030\017\024\007\036 \r)Tj /Span<>> BDC ( )Tj EMC (\f\r\016\017 \f)Tj /Span<>> BDC ( )Tj EMC (\f\024\b\030\026\027\016\033)Tj 0 Tw (-)Tj 0.204 Tw T* [(\013\036\005\f\016 \020\017\023\036\030\021\036\030\n\017\036\005 \021\030\ \017\032\007\t \r\t\023\024\035\027\016\035\017\f\034 )0.5(\030\036\r\017\017\017 )]TJ 0.217 Tw T* (\030\026\027\t. \221)Tj /Span<>> BDC ( )Tj EMC (\235\036\r\030\026\035\016 \023\024)Tj /Span<>> BDC ( )Tj EMC (\026\023\030\036\035\034 2022 \020. \023\026\006\017\036\027\021 \027\026\ \b\024)Tj 0 Tw (-)Tj 0.121 Tw T* (\007\017\035\f\016 \007\024\n\026, \n\036\f\021\027\024\036 \035\036\004\ \036\027\017\036 \023\030\024\017\r\024\007\017\035 \f\026\n\024\f\021\024\ \016)Tj 0 Tw (-)Tj 0.056 Tw 0 -1.218 TD (\021\036\035\034\027\024, \023\030\017\027\017\n\026\035 \n\036\021\030\024\ \027\017\007\026\024\035 \r)Tj /Span<>> BDC ( )Tj EMC (\021\026\002\035\036\021\022\026\b \017)Tj /Span<>> BDC ( )Tj EMC (\203\215\200\221. )Tj 0.112 Tw 0 -1.218 TD (\221\024\b\030\026\027\016\035\017\f\034 \002\024\035\017 \r)Tj /Span<>> BDC ( )Tj EMC (\030\026\027\036, \020\017\023\036\030\021\036\030\n\017\016 \007\024)Tj /Span<>> BDC ( )Tj EMC (39)Tj /Span<>> BDC ( )Tj EMC 0 Tw 19.287 0 Td (\260)Tj 0.112 Tw (\221, \027\026)Tj 0 Tw (-)Tj -19.287 -1.218 Td (\030\026\f\021\026\035\026 \f\035\026\002\024\f\021\034.)Tj 0.094 Tw T* [(\221\026\n\024\f\021\024\016\021\036\035\034\027\024 )0.6(\024\002\030\026\021\017\035\f\016 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 12.269 0 Td [(\205\206\207\211 )0.5(\253\203\204\222\037 )0.6(\020\036\n\026\021\024\035\024)]TJ 0 Tw (-)Tj 0.084 Tw -12.269 -1.218 Td [(\020\017\017\273 )0.5(\204\017\027\007\030\026\r\026 )0.5(\217\024\f\f\017\017 \r)]TJ /Span<>> BDC ( )Tj EMC 11.067 0 Td [(\026\023\030\036\035\036 )0.5(2022 \020. )0.5(\215\030\017)]TJ /Span<>> BDC ( )Tj EMC (\023\024\f\021\031)Tj 0 Tw (-)Tj 0.068 Tw -11.067 -1.218 Td (\023\035\036\027\017\017 \f\024\f\021\024\016\027\017\036 \021\016\032\036\ \035\024\036 \(3 \002\026\035\035\026 \023\024)Tj /Span<>> BDC ( )Tj EMC [(\001\022\026\035\036 EC)13(OG\), )]TJ 0.155 Tw 0 -1.218 TD (\024\002\031\f\035\024\r\035\036\027\024 \023\030\024\007\024\035\032\026\ \033\013\017\n\f\016 \017\027\235\036\022\006\017\024\027\027\t\n \023\030\ \024)Tj 0 Tw (-)Tj 0.406 Tw 0 -1.218 TD (\006\036\f\f\024\n \r)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\017\026\027\026\035\034\027\024\005 \024\002\035\026\f\021\017\ . \211\030\024\r\036\027\034 \f\024\027\026)Tj 0 Tw (-)Tj 0.074 Tw 0 -1.218 TD (\027\017\016)Tj /Span<>> BDC ( )Tj EMC (\227 15)Tj /Span<>> BDC ( )Tj EMC (\002\026\035\035\024\r \023\024)Tj /Span<>> BDC ( )Tj EMC (\001\022\026\035\036 \022\024\n \206\035\026\020\024. \230\036\n\023\036\ \030\026\021\031\030\026 )Tj -0.044 Tw T* (\021\036\035\026 36,6)Tj /Span<>> BDC ( )Tj EMC 3.784 0 Td (\260\221, \027\026)Tj /Span<>> BDC ( )Tj EMC (\235\024\027\036 \023\030\017\036\n\026 \203\215\200\221. \200)Tj /Span<>> BDC ( )Tj EMC (\020\036\n\024\020\030\026\n\n\036 \026\027\036)Tj 0 Tw (-)Tj 0.036 Tw -3.784 -1.218 Td (\n\017\016 \(\020\036\n\024\020\035\024\002\017\027 64 \020/\035\), \027\ \036\005\021\030\024\023\036\027\017\016 \(0,38)Tj /Span<>> BDC ( )Tj EMC 0 Tw (\327)Tj 0.036 Tw /Span<>> BDC ( )Tj EMC (10)Tj 0 Tw 5.83 0 0 5.83 478.4182 533.3118 Tm (9)Tj 10 0 0 10 481.3332 529.9818 Tm (/\035\), )Tj -0.052 Tw -20.637 -1.218 Td (\020\017\023\024\023\030\024\021\036\017\027\036\n\017\016 \(\002\036\035\ \024\022 \f\t\r\024\030\024\021\022\017 50,9 \020/\035\). \215\024)Tj /Span<>> BDC ( )Tj EMC (\007\026\027)Tj 0 Tw (-)Tj T* (\027\t\n \025\230 \r\t\016\r\035\036\027\026 \007\r\031\f\021\024\030\024\ \027\027\016\016 \023\035\036\r\030\024\023\027\036\r\n\024\027\017\016.\ )Tj 0.047 Tw T* (\204\036\f\021\027\t\005 \f\021\026\021\031\f \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\023\024\f\021\031\023\035\036\027\017\017 \023\030\036\007\f\021\026\r\035\ \036\027 \027\026)Tj /Span<>> BDC ( )Tj EMC (\030\017)Tj 0 Tw (-)Tj 0.428 Tw T* (\f\031\027\022\036 1\026. \210\002\001\017\030\027\t\005 \027\036\022\030\ \024 \022\024\032\017 \017)Tj /Span<>> BDC ( )Tj EMC (\023\024\007\022\024\032\027\024\005 )Tj 0.13 Tw T* (\022\035\036\021\004\026\021\022\017 \030\026\f\023\030\024\f\021\030\026\ \027\016\035\f\016 \024\021 \n\024\001\024\027\022\017 \007\024)Tj /Span<>> BDC ( )Tj EMC (\022\024\023\004\017\022\026, )Tj 0.29 Tw T* (\r\t\016\r\035\036\027\026 \235\035\036\020\n\024\027\026 \023\036\030\017\ \026\027\026\035\034\027\024\005 \024\002\035\026\f\021\017 \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\024)Tj 0 Tw (-)Tj 0.127 Tw T* (\n\036\032\027\024\f\021\017. \215\024)Tj /Span<>> BDC ( )Tj EMC (\007\026\027\027\t\n \204\217\230 \r\t\016\r\035\036\027\t \f\031\023\030\ \026\035\036\r\026\021\024\030)Tj 0 Tw (-)Tj 0.036 Tw T* (\027\t\005 \023\026\030\026\030\036\022\021\026\035\034\027\t\005 \026\002\ \f\006\036\f\f \f\023\030\026\r\026 \017)Tj /Span<>> BDC ( )Tj EMC (\017\001\017\024\030\036\022\021\026\035\034)Tj 0 Tw (-)Tj T* (\027\t\005 \026\002\f\006\036\f\f \f\035\036\r\026.)Tj 0.128 Tw T* [(\204\017\022\030\024\235\035\024\030\026, \r\t\007\036\035\036\027\027\026\ \016 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC (\023\036\030\017\026\027\026\035\034\027\024\005 \024\002\035\026\f\021\017\ , )Tj 0.232 Tw T* (\002\t\035\026 \023\030\036\007\f\021\026\r\035\036\027\026 \026\f\f\024\ \006\017\026\006\017\036\005 \n\017\022\030\024\024\030\020\026\027\017\ \n\024\r: )Tj /T1_3 1 Tf 0.365 Tw T* (Klebsiella pneumoniae)Tj /T1_1 1 Tf ( \f)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\007\031\022\006\017\036\005 \022\026\030\002\026\023\036\027\ \036\n\026 )Tj 0 Tw T* (\(\n\036\021\026\035\035\024-\256-\035\026\022\021\026\n\026\))Tj /T1_3 1 Tf 0.136 Tw [(; Pro)13.1(teushauser)-37(i; S)28(taph)12(ylococcus )]TJ ET q 42.52 101.083 396.851 245.212 re W n q /GS0 gs 396.850395 0 0 245.2122755 42.5196686 101.0835009 cm /Im0 Do Q Q BT 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0 Tw 9 0 0 9 42.5197 90.1701 Tm (\022\t\217\210\b\002\220 2.)Tj 0 0 0 1 k /GS1 gs /T1_3 1 Tf ( \222\023\025\021\025\006\031\t\013\025\017 \t\023\205\006\026\017. \200\ \026\021\021\020\031 \024\031\032\003\n\003\031\024\032\025\025 \027)Tj /Span<>> BDC ( )Tj EMC [(\033\n\t\023\031\n\033\031\032\026\203\025\n\021)0.5(\021\n\003 \033\031\032\025\n\030\031)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0 -1.2 TD [(F)-16(igure 2)16.1(.)]TJ 0 0 0 1 k /GS1 gs /T1_3 1 Tf [( Clinical case. Ther)-13.8(mometr)-43(y d)26.1(ata in the postoperativ)13.1(e per)-36.9(iod)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\033\030\031\030\213\b)-20.9(\035\231\213\233\t \021\032)50(\b)42(\032\231\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj /T1_4 1 Tf 25 0 0 25 505.4771 56.0378 Tm (123)Tj ET endstream endobj 1197 0 obj <>stream Adobed     '$''''$25552;;;;;;;;;;   %%#(((((#,0000,7;;;7;;;;;;;;;;   %%#(((((#,0000,7;;;7;;;;;;;;;;   %%#(((((#,0000,7;;;7;;;;;;;;;;4;""   T'!1Aa"4QTqr#$2bBRU %&'()*356789:CDEFGHIJSVWXYZcdefghijstuvwxyzҺ !A1Qaq"23BRrC#b $%&'()*456789:DEFGHIJSTUVWXYZcdefghijstuvwxyz?<wGt^د Dx]M,avi=mn@ntqi5tagVYѸЪ<iR-\Yf5xbḮTjxzgAcWFVZ*tѪ] _tD*NS5E{t:~zv%hш XM$ʰ}ˣ"^ TSJjv0'Nt4]#\+ES]N1)߭:^5 k.th12m'J04*$ wl8`ZΤ{4dR母>母>OCOE .jsWƟL]!"5|iw5|iȠ_}29j@ 4ds"w=|iw=|iȤ_}2_}2)sWƟL;4dR篍>5|iȠ_}28zH 4d;4dR母>母>OG=_}2(sWƟL;4dR母>w=|iȤ_}2_}2)sWƟLsWƟL]!"w=|iw=|iȤ_}2_}2)wsƟLsƟL@_!"5|iOE /jsƟL@]#母>OG=_}2(sWƟLsWƟL]!"w=|iw=|iȤ_}28zH 4d;4dR篍>篍>OG_}2)wsƟL{4dP篍>篍>OCOE /jsƟL@]!"w=|i繫OE/jsƟL@_"t~+Ѫ<3z;4xO)i4,m ߥ=zOKtaV-%ў])oEXRֽUSE-S`eihVŧ}5s5ftGi])4L'VY@ J{tCӋ:0q<piҪ< HX4'Mx(Tрm+vU=& 5sr=o&.©UۻQqhoܗ7 t>Kf#Ykt~#@ecJJ}Orצ4i)=z4iZW05N&.% 4ԩ:wFm+)£IZ"jŪE*54˺_CѰpZ5,<*]Wlh1د E۾S G^fGJ,lU U4— 癝;Jк!m:bUJiI6sۭ jkj8=FGq)¢LJ*)SS}@P6:oBFN&`SUtžk Kc#CƯ *CVNcZCgnpRWӆjtQEXV-*R@eAZa^t(gЉʸZT'Ӈt&,D*xÏ pok+MZ=UUTEs  4c:-3Zi=n.6@Ъî%K4Dk}: *\\m,L "=Gvh)उ^Z&X.BO:1&]T=FbXbӪ<qM.ƨշ-#^:Jێ,w~]b5 BYSvS֢^w-C{̴KU|:cr\S[p.-ݲA-mo>q%/tPے;OJJ޵ ӿ4tg6M/BmaQ i=!]*X$UZy9tq翷wVUU)IE=mpki<LQnĞN`Ӊ%SďYN7FWcn޴w+t+jz1ttzP˚aVb^fb4qU820^-p68xuְunse MMMm.m'4z? cM|4J{5>%X$orNSu ҽ3tgD6!N<,53zRR[2Ѻ;1q4js.ޝhK=+X*4|5F ViK$yn)^qлI*qT%M CWV<J |] a))[OԪ<QNw^ӱn}]XQVժB*}tZgN*CkĭSD=U=F:>6]mZ\3ljr-"#W[[ $RNGz܏Gp=:NV.XVSpzF.ӱ70^t*&-j4iO7 ZPIZEiSQ򺩹[UrMaeϟ)3ee^[T3[6Kn䷵$vdо)_1K^oi&Se'DӃUvUSf1qѿ"=#ѭX,v5OAU%@6}UftWŸJB㿄P2I;hikW mtۂqSwn6WT)]y´~y./Vvq֦]՚b-RrY>ѩ~kϋ2{,v'FƮ2Һs/ұ*ůY$0*BI2JsǭZ)mO@IiFĪphTЪrdD{T6pҠmOCoW }* AwtUŸJޮT諅>诅> oW }*zSP0zYåVN\wpѱ+zXޔަrT*ӦZY/Ѩ#JST)S\TTTܹ=JⷑU:1{z4*7-goQS{_Uߞ0VJ)$i4k"bbkn8tj.Ӄg8:6N]TFTub*[HRI+q3y5]]%[F+hj=+"k^aAW[qsYNmQe,J]y:Ԏo=V'^WS'83^L lUI:2N5v z+:;Fbj5X>j曫=yhX9*mݼԛ܃K04>0%`baM/{V`PZj )tMMF-$5E'\=J +ECz?mߌoW }* AvޮT6pҠmOCoW }* AwtUŸJtWŸJ Qs%I\24Ltcɾ߸i oW }*_ }* AvޮT;T諅> \))zSPSPR pҡ> +OCoW }* AwtUŸJtUŸJ]>諅> oW }*zSPR T6pҠmOCoW }* AvޮT6pҠmOCoW }* AvޮT6pҠmOCoW }* AvޮT6pҠmOCoW }* AvޮT6pҠwE|)mO@H.SQ]uܸPժ<kGKQMXq-L4<]^*3tޔzGWL}]JQ&b4ݷO#{lӫ\I%϶Eoν(gDn?iO7ߙsbcozӕWf#ZRSSxRf!jFת?GFtoȏHztseП%i?`дsI4V |m쨺a XVcZKtvm]3#DTbWjttJTvZGz7JӇ%Gbz7JٖR5iƬqT{N浡J.rlY6RZ6uF{ï^W6zAtH]Eç}Tnɉ5ׇ[îMiås/A8x=ɧvubm2ҥ'=LCܻ F0*æ*ԓZӞ_JV5UZjy=h!WIbxFҝX AL\J:jE}7|  4֢,'NU`WulzO+FLæ4EOV[l:W4+uh4*5YՉ Z4rP'mhm̯q˫RoFѤwQn귓ta:px]\\r~)JFƭ^1jl:x\d`ceM>IxcSN4 u5SC*wG_6% >} 65+zܴ唞圊ڳ4J */H穟~ ¿$P.2k|Tc1bSM#OįbU]Tҵi֭qm:7ܻ:'FZ.] :*u]g_gbFcczrpD۵w,H,bX\)1s|$专B ZTc(7<_ al&RPyIwW6c-howߵ0VkR߭gKsCŮIv2:BNJUGQwABT\>敡K+?zeNOrOfտpvRӾ=V&҄]g8cN5-*uUuP"QH K :vwv5OHuӿZw}/Q}5BqV{ jPh6}кgM<*jE+`:CHpp֢x7 aoDKwFn)ES휀]wIVGu+4^hѴlm3 &.#hKl)f:G\M'uӉ8@֪<؉[Su[˩ذ{mO{*0f؊J})gO% :ΧHt\窭K9{%S+㢓T#iH 0̃Tn:7G~Q:4~DzGӛ.S:2y3Zl䥣}|8{VG ص'H.K4-oޕYW\\'NEm|MDYΝa\rUKY9]˞;4NM:Q. ,jv4㬞]y3^OQ˥S 686]9B1Q..٬3 ;gGWA4cUhғ« *V=/ܳ@ *jt,-ֵSKZRtt7G]5UUU=8ukԱ*]Hnx]/Ϲp ׉\D·5iMZ5:#īְSVv`ؽzGB\7NŮtp4|8׾a1*ƮJ]Nܶ@!FJռjmkG9 R|1[~k~]6%\! mJ~-zu\k^I~I:g/zvI6% >q^Ikun`5*{1%>=:%ri/Vx "t|;U0.iJ㇈SRxh2Ҭ:rأ|w1Gsȸ%\%؉QNTť#]Z05:9m}SiHMWԹUK.MUh$}4yGDSw8ϑ?}=);NXT(i ye$ɭǖFχbmVumJ5 LmEFJrYj tpq®uaԔn0 CtVţqq(S^ Ji~rwNi}ju8HǕn.ҝ/9`׫{ަ\'tf/EF-8zEiԝM(K~Ѵl>ǧDԧFMT}.a#{Vz>&ETժwά۵}E}#W^F&.)"m7 ܯ:7|'hU5<5S˽ -x[nŦ*UT="讕4^ӱt bQC]+sJl ePH7Mzת<ݴ{Vt&nd#F$ݴVOrMq77LR|υ=ūQiI V '3J@2MQߑGӛT~Nl䥣}|6]RѾz0-oޕHOFZގiB)Ҩ$Sh;Vz?Ew*j<OF]mi}Ξ.ܡ%$q}s3Bj8R}&q)CNz#Q%&G)5F Ch^A-qU./zp j@y,Įcg]Kz)IiNxN*z +4QIE7K;m^_"meSE4ےN{ms4ϯ^䑦}|aco?P/:A(QGJU)Nޔ%t\bwiuWʛɢZo;5T^P;-"zWG{Wj󃗼 _O<"*գ[)6bd,< |jxR^IFTaUfѻgiZR[r&tN v)uܢꪮ- n:SOѾQNzOsG;~ޜ?IFߧFp?DF6-3á֖YԶN>M5ӭHF9S.-q=xuR-25ӯK5'j|v~#VnW}HQ¢6O ҚYg i*qtz*ѪÇ׀c1%MuP暝/pDЪ<¦((u%UQ0tGhZ6=[ pâ58ʜԾ[6GBtIbaӏEJu5ښ߆XU5OpD)ٽt, :;J=3EUWTBKΰE ҩhzF5/iz{0iv'tiz&6>kU %uqff]Xxk\a,lD0i>F>6cѯ[uҖKt3ѯGJ}q5JkUӌoS]gӇfm WUWhR*T_ ,YԺu3}=P ސXT f>zj|jeYLOF c1/&op#j;̯9HFA7#?^\rWm:.UeFl OIh_=Faj*͏BlIh0]߽+[YSq"^eq*SUQ<=y+*xk:5V m>)Zkzg JigtC+Q%&t+uUUnoƻMnhJNoz./'-eaK:9=Jwt%Y?F]ʄzMO|˩i.jo&2XK^[A4=Ѵ+U=򓵦ƩF cOkWBN[\׏5-sbV- fܸ1p^UOqn2Ĵ:j[Bk)= Ҡ_8zU WUW5p<^z״`S~q, j7Vu4m-5XЩǣ/Yr*L*NUUWT\nLZ+\%WgGA%Μc}ʱbWW ,çVW ΋H>a{UE8n5iHh t^J}pRd(QFWUWm`>WUOggJN`+*r~i'E'u5o׈fmIi jK^ϝiFp\U޹\/8Y\.-eRmGvejS" (Xo6zU5m+B+=,NaJmE WU^K .4zA@sNBuTz|xiUjqJJPR'^k(4bӉ:qP&UIGm6KPmPjZN/VOo-lҥ*)RJ=M,DA'/JYB [7őnV<%xZ)&WFtV z.5*Rom1<| Uu MOa<TUEJb뇹 Z Xx 몱jJSì b/oozK JTQO*im9iMaEѺWFi4j:uRU-L}At}=#tm!w>-MRW*^YzVEThxI`(Vzyv~Nү\zVR=D#o'a 3]6/?q++yEQg-9eݼToP;Ҋkky`~HTm5,_vVb0J[̼U&C[l7]U#F| +X~a֠CM&lb$vү\jy*]zJpjy*Ʈү\)ڸzJq Avү\jy*]zJpy*5p<^zH/zUjy*]zJpjy*Ʈү\)ڸzJq Avү\jy*]zJpjy*Ʈү\)ڸzJq Avү\jy*]zJpjy*Ʈү\)ڸzJq A~ү\WUW\=W^zU WUWTmu8Ѫ<NŭN\avcZz*3)v,hzV8:6&[S LtޓK)TQ(nI\4a2tK*+ Mұ)tI܃pq(>0҈k YnnE,K1tbPݵWH`;f'G}8_Gw6ETmq1.5oM(gTmۻgui\.)UQîjTRʹ5_O7Pi&%YҶZy?Yi6u#vwY\ukȗ9A1 mJe-sጸi p/]\9h Qj|y=Nұ)ՇfZ{8Dit^je iF )Ӛ2[SGа,ZE `j>ۛڡoj s|>VQOKSMJ飜,jkWqRN$܉ tA^Po'f37eu ӗ9F)e|UNuKrh9Ѱ4NK>F=RhUӎx;o<߆|i6!ZuΣZg޷X螊n%,K)8IJ0Z&ܳ.]ˮkZI9S[J8U]F.abquSKi\;sٴдS_ UNM׋^Gtn@ :~I:g/zjht7LIÎz#s*4}Jll*ZKrK;oq>&'h-&Zy9D}J}{'P59WYWʛ,eZΧuYŢZU7Fi:csRRgpٳ 3)-;wvt)O7&~[_X#*1I$IlDvhzմBs}>uz%%.&"KkF)9[j_h~ugJ1#NPQص=^hLg5C[(T>7Z?Cq4tq dpqӚ1*4|ktZZ#g:u6?6"p٨:ieᓄj)=Å.6k]%<~qR 4)ҎKbqlNyӨdn1.z l e)SS{/Eѝ:oY!N")W)ġ]QZְiS֧(>\8<#Wtn\ te"эKRciXxv}L#r&o3 8tJ5U$n3:'HtFv¢{)Oqн%FcjU:E{kjϊNZKcV<= bbQAzvV.`RZ/3<WKHFѺZLjtҴwT!Sx=5)ŮZQNi{t4ǰѥMptkz>'G]%-GŭӅFҺpޭ } ZNQq N[4]}p);Iu54ו 3 8b:=L %NU]5.[Ҫ<tSCM =W/i:vhuKB(5K[wGaѴ%-jIt97NWQEbcoZU-Xk`{[@HŧMѝ:FZTziN;'GEh z.[MwOc<0 I.6`r|l5ƵJaVם`nz$whm=GYnϮfiukg[ 0\M#`^'蔚g-8O/J@՛T~9ߑG4ˠJZ7Qe%- HOFZ,<ѿzVi%n?)5FקJ8XRjw|OHn>H} |ZR}䕦|ӘgivUi<=x0׸ͼ唣mHQEnȮ*rMZz0Tk;F%:gV04.u{Uanɦx3G@4nnHJRN V}fx*Ӻp]tZ= =*+]j5){tFRm5CMoM5sϹM`=TQ M4PS=JtҊ(E,bKwtF-q m 8ω0ѽTSM5WK]ΑF^6Z⧭&ӥt]3A4zxظEU> Gr{gV[Wi5N;߸utBtK֡ԖwiRׁ.*'CNXUg-$=#i]b:t|L=R/~`q+Uo{mfG׼_uo?P/:R`[Jx[NzGJqUc^l:o䣥}~ޚ%{G3q0`{ioG6lz>Hafc?gΝZQ,mtӧP8,\H :iRܥTқi]eh+ҩix&^3.&Ӣ kYæ{z<_ppXӒvw{Cơa`"^RMi^#ydZvi5o;={.Au"jw\ۍK)t֍]rN\ hkNT'SDth-#z H*Щ=X=.^fi4ѰN>i;[#1TM4O^Ri(į W `NŬ+Wɮ2.z' ק%(iM4 + KNVVs;6ihYםe*֪lLt+:5x`:Yf֢R$BL5CJħZM3FWIhP}n/Ҵ]& 4j5p e~f z]3_iTK® J=5t摷ZiբQE<)E=#z_Kc,}/*U)T% @nl-(0(ÕO:m;A讍 #Ӊӱjb#^>Qi:6"Si3OMlĦ X4L0Ӫ<S]*57 zSL K}b,<UZե(֪^y4] }p鯤za`QVkCz.M*@Qh$îKV)($(:i:K}NE_G`SVКޝ ؅Q$sͤ >G9iXKIqWP9Sܰ;*ye#eJҍ5㴢#c檟0QO@|~1?D՛LOF^'蔀FtoȏHztiFת?G@6]RѾz֛.)h_=FZGz7Jf帞ҵ6?QTmz{䣍Շ%&7zWD_4J#_k4IZoڍAIZoڍ@m:䡁 #˱=^'! #˱=^9Ѽ >;P^Ѽ >;?ֽj;J>iPmϒVH$34E1}<6% >oq>5Oyf:}[,?GO Λ)i_GJW5鿘?J=4`(Ӏޏ.'m?٨6|q>i&@m#,O{I6z'Ԛϑ>Gq3ѾQNzSs #o#8`#Pm{gDu$a+3Jnd%{Sq"}!ziEDӪW6](_,ܶx?@m7W.:Q渡`bםmR^>9R~%NֈzGJ7Vs7H.ŠWyoRP˝cREߚ6C}퓖KF شgbwUJYҨ^nJ*3Q7dԪ<#9MY} 8#^KCta`S*g\|*k:cǺ*btHcci.zKRJSYN ,L:t -UKuTsԝܗ.EAįHU֢oufu``bNéRB: SozWΕGc<5GF*ukZӂPomGMOwLizGDװx ̽'K­.t?X ,>ӺGO2Gé%ߵU$G77`>Jp^nQvi^V[:RNK<^+SEU5U*fɿYB+Nj)z˥cS*V z'gZ#~I3@aя]s "Rˁ8J߻Ҧ=SN$BNk8.1ٞonÈcg_~`T~9ith>Rn|:iMTt:pTSiUgE le%iFb袹juG)h±&I>J#p6ueGz7JK]uT:S̊=ǰEsg+9EId糿g8WEHfϧ)5foJiTiUxijTƲIڔo{A?ʴLOYjvst]/1[/ޕG>M!04 kkSr=5ǴcLj“ujJKUey9º.Bο7+NOpj4~iukt´S3.y JG2M cXL%RY,>g_~l 䡁#˱=^'DҰqgR}U.9*+nu6g'aJ.\Kbd֖;֦FSg5+_zgt7ZF%=K}I='zV&.U*.p8*O,ےQ|"ԫο0-Zy{MAitbh:.[Vڋx9º.GW iU6MIea:3$34J#Gsį kE.=vst]/q"GuNI4R{^[ο5۠Z}FtFtʡQPҷ[=vst]/p[#cg_~`=[lJJ*{I{Aৎa5)ƢiJI>9º.B_4*>TkΓ(Ҵ|l74bbURmE# O*kjSZynp6uf㦷hwJ=4Ǥ-+mMJ6kh<Tuj;vst]/ ~u."IPl)ҰFף7UiFJkh<0juMEdo9z.Bԯο6= {I6ijFm3Si-Ƽ,o \,db88+Y5$5*ݪgF|_='}3+q(pq+qESd4Zq\J/MU=vst]/"n7t6oUÐ6uf1?l6=-iXWV+ M 5~g.p׳#t.Y˧s lq?6}Ӆ}o}vX~Fq+x$u9BQg'oCAZKmѯN_Nh:F]QV%LxtǓ*ګ9ʢ|价tЋwӆ7 ? xLW5-uKV%-,?Bq+\;êׄhOsz^&ZT٘WF=jMn5 !kF jUjkQxlp^BxiR_k4[LWMd̢i|gXOEސ^k8UՉ^ WNw4D'tEc,'LoRpry],wxSK6i$a64.iʭ %&ڟ} uf%.sV9mTN5U-ϊ ޔpj+mppniP)N;u=i5g&.ڽKqGZ.I4st]/*Sk]MJUpd@*u'-.~F 8vMv^No}ŤgKp;Z;R>O58tԷ7>ыwN.^l:Ck_Gl,MTẽTg_~:7.!Bq|^hj,9Iժ<S ?I{mJѨV-4%S*q(UU'8{M!^M'Jkh`a:0ުQ( M/HއZ=S^&n{L,nC%hkRߺþg{讈Ap4Ѱ4WӲ~EN3*pq)J^wK=˺GGV4 %JLN{dّ8^雷F3I{ƏSr{>,o5AF;j$]L]d-Gi\<eʧ˞e&Vҿ<,hSa u+ڪv&䏃%&+tEpVtY.'2K8W矅ax6T`釛+MyC/[GYsh-+*p|jKci_~j ތIĮ8q?f+t '{(2XW矅+T׀f帙ޕ&:-%rg={(2Xׯ? 3zWFC0pVX.&ӧJT~I1=p fݝ6"]%im =g̨ƽ^yY?HS]Iйu|OJb^ɫ:im+=WY~\ʁ/W矅 E4w:Xj*a7+MQ12]k%eNȣVhYr 'I7'=z˙P%~yYxhf>0*T˙lzo䣥}~ޚWGyS;[7ۼs[GYs*? 6='ͳQ鮫|5`(ӘyMt?cI{MP%z:8NwJS[Ӱqp4V3wFG9Ov~\-Y2Xׯ? 0Jz&=4aU7f6v~\v3*yy^YP%~yY6]˅zL{T̽5JWf+tjʚ祚OiƽO? 6Zix].Zi译>G1]{(4&m0#*)ƍtd\iK56j][]Ҏ<La)^%xvviuFL- ,ohB!U*k5ym-KE%aTIT9Ֆ\*MF`JXصUN%ؠUц˻9$ъZ-6T,O7,meJU)Ji%6#uZY=xʨ]5-NN;tl=0'SR}R6?5G׌/xj xuhS -j:yvGWsq6$|gEcQYkRU.'*6ʛڤ Yp-!I-z[zKZ)ī6T-۷HltҦj9u7[4 E+f0yɥͽ чs8 J+19Se2(Nm+Fޑck*VE5Gj)xmeޛN="aFDj eEQmpm\MwAį%o-jT9kS$ɬE.wgBTԄ8椲h[0TiF(IF}R<\6iu6ȯꦩjF::çYnR;?B-? MJwSQVS]A4KJU.JtчzWDz9S*p׋sRYϝ奼-e xL7yɇ,^<,t%=5TѰ)xM9NM7"çtpxt6IGi:X*TkHϿ?DF+t.U>tkWIfek矅caB|JN+䏢}}1]{)u8z)J\M%k3,? 4G0t'ξt%{ES65C%i_0S[GYshdJ9.,m+1z5^:80@tFRm^i><~)^mʙTOXA"yDxUǫVF%tdT&JŘ[G\ⓕlӸNnM>ff;Kh@Q?.kYSpʒg8{Is>5VF^->.wLȯE]z;u|>is抨Snn5XU7CáSUZq/xVO j ֤ͭ*mpE窺K=={(2dOyĖdm+} CѱiOiV.wD#qb'[c(Tb{Jh՞{Kh@Q?.eAı? 6.zï S{EN5E$i_p}4&Z+d~)im =g̨ҿ<,Kҩ.Gg׍.?^IjbhKZ-rTe$ܟyP$m+RĢԓfGI`Qi8~CUɔh]_L )Ưޘ=z˜GEt~9eN\lK`%~yY6#aFG=n}61QY-Gi]OZuzyge6fSaH}:כjWŞD1]{(8z-,ǟk>'j2KJRg6=]UxZ5UxIzzuu~I-G]k.Ai ,m+YaSaԦ)Mne4QV%TJi$h^]-5UU5WF55bRޞ&&:+ю |m6߆s[GYs*eJiTi8t(I1дL]F׊I_|͙#/fxTUSMu^y-0[=m='/N﹇ҸhZE4Jx8UonR6quciXiIiSJWorl*ڦmܖKo@u@ftGcV^$pU5*`֪<âJ颋SI.oq NJ4:V)=3ϩm4^|$:I0p(7+1h6cWFUNETZ:=ɴ/L0>VU.ZZRlĞQohU^;N?j6Zqk4:!gw]j\N<ߗKצU:.m.R*iuY':3ؑqW>:W΍T<댢QTԢiGV щN&'sкCzEz_HhI׽*bkWtua_Kt3E} јO(Ʈ4X:֭6Zqr*&jzktV_xUPZɥh;>3v#4UVשK5>ܫ񫦽R% '9K^^] \lJn{4 ZM5*54[Y{6GHbӣh8}Ult7OtEVŪVm'izFh kHq5ZVk۪-Ci)ۦtaGn&ΏZҽ^UtՃ[pPm:䣍Շ%&GJMPn>Hn>z n4?VNn4?VNN(`z#HOGW3䡁 #˱=^9Ѽ >;P^Ѽ >;P^5fL%h_4{I6g+@{@Pnt_F ޚcs4ϯ^4G׼_uo?P/:R`ynޕ<@7J:W6=7QҾUMpnzo z1鿘?J=4䋉O6j $\OIPn? jMI+?FԀgF|_=);tgzsҟ#_a~o#8` # ^Su$a+0қT{Lnz+O>QAģiJ2Y4]B)*ԫ3ϑaӄaKbG`ypJ*T۔Eg)6ocq>hiJiƭ$$i#$ѓ74؟3Yv*T㜥->:Ivaҕqޓ<ސO^T u%([>?{g8B1,7z_'k#_Om}>}8KFpSҜq1nnggS1MB4ޭwS+oagYza2ƚ7 ӮIpqj]E(ѭ-I# qpӚYi*V&]x-Ru%meSP,C^O,RuМg; b1QRI,єo\dn kӵTϊ#PīYۖӕrYwXB窣S-%;3#Rl2r[!!-=t-nl4zXtgri%?DFoO}#w@cu|O_$}~i ·J~az_$7ci?%њi7ѠhKIɩ-48;#k\Guo-tl*buVu.˅o37F{ Lm>f67a䜳˱=^hhOv[:?8l0A8+Z[zO1p+©UCt/Z5FN\mқftW@[HtI*;},88iaô JV3)rˮ6fRYbqq%j%O~Ip⧾_b]RD5SJu\Y#2m4fё=Ĭ*jnu%Q7k$yߘSM0\7Z;$TRڟɷE]J\is=´Q2Kep T$[uoxQRU~J<,*궪, ' p]Q-˝ƴhaU:*Ik7J1bY[[{GUjYS8Co<;cx 0qPY5jwJy *)\*Z6;ՉS|޵:]K}^UI5pQT"b"]>_mAñ>n駫ݖ\ux~7L6Kb*kkםifKp>鯒zhlo>,s*zzk%Rp]ֲl7sݏC_5ŸӫU):u9DTn:kvj4]^n{ϧG/nZ{NiBMM}ox~w7ƠSdJ7}MhLz>H/ S-mcKO$9EgGUiMoo/a>"9uƤ Z{5STzS*6zRhc#QUc*;J4SW]T#V;1]Z.4CtQovL踘XXuap:ӭNjVtWJ{zf>=ZUNΊr㜓 WB;JaV UŸ%ʥ=*}pua=ŨlE~rHv)y4=m+1,]pmTM;G1f{*T_U7?#m}:æ/ ++A4p1hL66ֶM:fG)c4cR%Z{siYflmSPNJf8[N2t饥VVxсVZJ{éJ: ]M4\10pĩTBN3k4ޝt^(MN":!_> M7KӴ]'&5uUSَת<3iLYZ?N/HWѵcw#SeM4y0ryuM)җe~'{ѸxwL׃Cj%]yL(`: 0pKGnjo\қ~= DԩzSwSwcPZWevɪuh-*(M*[ܑU*TI6-}(ҋu+={4Wv"MRwXq 9k6 ,ˀK^x+=ҭGؒ%>ɽǠtr֫i:CqMvQexQ̹I9!UJ5i2ƽ uYdW%1P*+)ESfZyx֮YÖΕҸM<Ҵj4aǒ*xm2Tjo+FFҩNkĵɮ&8[ԅXF))i8mM=v%:%7:;^8^-'Ro*u7}k:v=%i΍'Mҧ ZG;}}q4WѺFVV.׾ϠZ/Q_O3MSFpSJ],<ѿzVi%n?)5FקJ8XRjw|OCw|OH}䕦}䕦|ӀӠ~J<L(`z#HOGWto/OFwN1׼0to/OFwN1׼ Y>IZ#j J>i䑦}|$3 1(QF{(N2-tҷ:}fKJW5ǦJ:W MQY77 Gf6|q>i&A䋉O6jmWb~I6z'Ԛϑ>Gq3ѾQNzSw #o#8`#Pm{gDu$a+3Jnd%{Ss_"}!ziE|ת=ԝ*iRqQ 7 M1џ#?=0WVtCժkz|N'eNJͷ\H!)gG>ۥo'w}#)ֱjPE5Ywgkf:6bѡiJJ-$w;a=lJxr^%j)M#'MWb[c&ݿ.iM'SU;j]\5`Qّ~!:cVy&mlNҫJδ"[.%d@>!Ksdg _mqwVZ[)Tmdf=U7Ўǖ^dTfO;'E:xcJB:ؚ{=1cYd|.a,BzG>qvy# P1r9Xea•U5rNg'>/{jzڪg6LUH׭Fjkd*XjِtO 1i\]CeW] v=7SohC*"_JjgGl6RYҕKk28ƹϜ`F0ҭ)e`bWwY*ZŦmY&-)Yĥ͗(nZޯ/ĈU )Qz3>bՕ-]tOrS|FESU-.&u8u4WyJ#_kM=jSrfV&V&VnVw KL3s߯^W7+M=YPV4c9JZ\NLm:H j+XڪS&imuGNTk??O׬oup>鯒zayvޙ5Q@\mkvGf zPm"D5ޏ-a@^? ѩ5Fע|Oj@Tftgza;}ހ[{H;G ϹoJ[;iǹ`?#NЪ<]Jw]lN]?{ J4L&&ƥS{;vWM.*[p'=L^^K3DѨMM8$UJZ)0t.|#)KZ~IPu{-;I4ZFêt\pg^@;Eh:v6SN5M R&5^87VjXͧ/q q00LZ)tѤ:ҢէR%):ɯif峌V{R/rywelJLCu+כiPmϒ^H$34E$i_0i^IjMBxߤ K,?GO+{0<@3J:W6]7RUMhnzoz1鿘<)(ޏ.'m?٨6$\_Df6z'Ԛm p*FԀgF|_=);tgzsҟ#}a~oӳ8s " A}̯x)}̯xJnz+O>QM1>T{c/G4{b]7}ޠa3Q0a~KD𼲏D]L~G4OH|i_?Ff)!y.9\.n+*Jka }kk;uel(Qs||LLkM_3i^pz4є|*wӞpz&-Ţ*w=w6EL6 JF$P絞Mۦ}EOƳ*]\Y?%;NEyjk:W*q?+ޛGbK'3Gʮ<&wuUWɵ5meu.*[ZaNvz-5YeYWݎlFOr(|X!=[Ylp( Fmonپ'G)ZUpn6Z:O J3ixTh 9JiM0]|}tl}t?]#N|K>au)X]%Ji:|lҥ8V*U''žcacUZz>0Ut„iM<<L(c}*5FӧJnXmtfё6_3@zGF$i_p}4F$i_p}47:Sͷ?^Ijj.t3J:_釣vޙ}3PҾW@^mkvGf zPm"D5ޏ-a@^? ѩ5FעOj@Tftgza}7GO t&K(Ӵ ǹ`?#Nn=>FpѪ<1+~QܸRP'k ҫ xx>M5Up-?Kv*XXF44IN?. ?L`z>M gm;Khѥ.moL;EK 7Y[U'QԋmGnI7ok^RZ-(lѻyZY]n.iMJ y;h'we'OUIp3]u ꨜJI:cIԓq jIq)i; ܲR6^Ia7/HN'MF]%IWm:9{;*34+j toȏHzt l?:&ˠXݛA(Ih}=FEX[l^T)V•޽N4-oޕHbGMl?:&çJ8XRj}GD_^yM__$}~ҀDx9-#Q_h$7F7=VCnf=$Yf_@p=yv/ʽ[7޹Q4g]!޵uik4o/OFwNC8x~uMV/@_cI6g+@4{Hku7gyu.r䑦}|ÿz&נ*;WxoߕI6#}{'PkXRijG m4y̞:}lzn>Z_z׾Z|&[<7>JZ^~UMhozn)F|٧m:oz0n SyzƧ[ ο >{ DՅqמ(ka6=O~I GUݺ;TcQ%ҕawn?zU#7=?;ο 熴>l !?lkuByh̗e{l?:&㢞rtzQr近>G`ekzf޷o3:3wFG@i}1OFd釦gM/=k5u2] Z^.vbjɧ__#OOљHp<;dfp\R ZSU)jN*jym0w2GPVM74(kЛJ;fRZ=N)L9{X>%J UU"nPTA}8}^\̮- +gOhFirojq˞c4CmeTk0fbJ'wW-SGF[*Sz}AmWWZشd<$\E'JUbϥ¥3G 77¦OM~aj,)-}[֌aVUTiUYmٖLysNֽWoVޢrV;|%ΞV*ʜUKo,:2T,(򮻫oYj,fYMTwkI-mvm7Q9,OIʺqs{0vپ%G)fFkXVuie7 t2ݫz[V 3>JXE[ο *tF޸Wy4FI$h_kLf`>vTYʔܤ;+ +95y!^Ҍ%$dڔ{T1̣ E#QS}eiXx8]J/_11014֦Tb-״Kͺ҄eyFI,ؑ֍*t)FBQVĒ;xLE*ʕ"xXK qf9CLV Y2۩nVOyǸ3Қ3&6pY5k ZZZ-b8-==-7E\ME<vN4Q4, =h7w4q;l*q0+ަ莙ՇxE:1U-kd=o Y>'=FVh>:jO}Kt(ngz`z}=wlUVyq~~UNV iqӔ}3VGJګ']_LtmiQ./ћ~ݡ^~( n~oCBwe04fޏ5a@a6VO]VykS&tK=? ѩ v~3^t~m95gF|_iK<5iǹ.8.z̞#vј i> 4n&ۍǹ ."4Ҫ<$MPˬ^{BvvxmJ_#^+ӹ׌›e&T^u7Js5*ODAOa6^L\#a:/W蟽6yzf3JߑG⨭xm:7G~Q:9?ftKF0<ѿzV4-oޕtGJMQ7V蔚_$}~+䏢}}ޚ@h$7F$7F6PF؞zgCGbz:sy~}3w䡍ֽუy~}3w䡍ֽj;J>iPmϒVH$34E$i_0iBx5G׼_u'~zA,?GO Λ(__GJW5鿘?J=4`(Ӏޏ.'m?٨6|q>i&@m#,Oѩ5&ۢGq3ѾQNzSw #o#8`#Pm{gDu$a+3Jnd%{Ss_"}!ziE|ת=iΌQQftgzL#^*3K38ixQ藽#_tfb}#9Xg0:62խ%8S)V W"PC)Ӽ8}> ګN5+\:$y vXPlN%i5 mxhŽ;΍hY*Od[8ώ[WN[ vQ:ssE4Jߒ"7D-~ RɧakĚԏRGI(k]FE\>џ%?DF>U(")|Z4WTқ+䏢}}4D%i_0SNnt?V 1?kRz&:^h@tF+WҚ}.&%4`޵8T,=h~iv:#ܧ:- *jӉMmK6-u{ӝ˰S@Ɲ;E}!V9*U:ir=+UtReޞ(c}*5@:s܃O.Ů(įZ*UըJ]gS6_3@zGF$i_p}4F$i_p}4~c~=F,?GO3:k䣥ޘx]gM|t~ݡ}Y65Bް>H/ 9_b4ע|OjMQ+;}ޘfgF|_i.>3o#0@qA5G>ӛr>DFӪ<$ӿMj>#9hʄ_-v(^FqvOG>>V6E Ovu5T|[t=#ӬיuK*zITw=ufTm]'q AT{q# :Vȍ8mii*j4W)Y5|^*p z*u2s'UM4JuQ ^ ]-Gk-׹rt)art8k6~BYKmFϣ~DzG['N#Ngkeѿ"=#$i͗Ao5ˠJZ7Q帞ҴYyn'~ӧJ8XRjOqDJ#_k_$}~C%i_0j4C%i_0j404.u{?~J<@SQӿ% n SQӿ% nVmϒVHo|G5E$i_07:/#L@LmGNRmJ}{'Pjf:}[Y~z7RҾUMq鿒zks0`{iMQY $\OIPm"}MtG`XRjMDy^5&3:3wFG9O>Gto{Ӟ6~|Jқ# ^WȟH}zޚcs_"}!zc3>Gt{a;~ޠa3&L#^*'KޑU_8''2GsI31 ̱e.eɜ$CrYp?cHPƧsV8-HӨG6^LCU.{o6gHmXЕJpmלn1#M .;<6m!h%]ɷ<# 9vիWkkq)MU2vZN[uuzTpԭuu6şJ++fG8u n>V WPQ>-7x#'Qf ³;Ƭcq;TYeb鯾[+Y ~pv-ĺ0z[bYojG.L5=&IhW/"cc%?DFl:䣏 "Tn>Tқ+䏢}} )IZo/T䕦|@Lm:䣣3Vm:䣣0OGW9Ѽ >˱=^F?GO (c}*5FקJnPmtfё6_3@zGF$i_p}4F$i_p}47:Sͯ@|SF}`fa:}_%/~?GO3:k䣥ހ zAE1~j $Z6ZRjD^_Ԁϑ>3:3wGO t&wK|i_r>DF{|Q"4Ԫ<[1wQ<8#5Rѭt'MZ6X͵z3[ #F*#ZfI~y'3%ôߦ Ƽm\gjZbTi>Z=(/iL*J|J )jΧuyfQmҒիnv*U19_a)ԍ^HI>[?9ԫyR^ReƗ8DUլ<"pT-$$SR\fGq06=3 "5ߧF?D@7_2G4HW`7='^WȟH}zހϑfgF|_}/? 0a3&ye{5 8''2GsI31 %N2SOV:jFXR3wVPq j57c$7٥[7;NYB[iaWv}VU֭I<IiŞO4S&6^ܸ UvԪӧg^*BUi(F#Cן/ F5n5~QmNv{Ҳ7UMkҊRJzݻ(/MHa"})ykZw#E߄*7H/Rҵ+xtfiTқ+䑢} )IZo/T䕦|@Lm:䣣3Vm:䣣4]:7az:}?bz:΍^z=PwTjO|1$#Tmtfё ƍH>iƍH>im??O׬oum??O׬ou]gM|tp>韒zo[/:=5ߦh_`t{ڀPn("D4⏒-a@ӛ^? ѩ5Fע|Oj@Tftgza;}ހ[{H;G ǹ`?#Nn=>Fpժ<rT?q=OҴMҢ;oi }>Ui]5hXuT骗KBJ}tq|=7IUaTwBU*G@ m'NFѱmMXtU:*uP:J]'IzS#UMTw:wzzC}4}*Ӵ/WNQVt &m𞏈k?fFKN6OGf6[٬YooQj4-eyE>z&PlӞF6)G9m5n24l%/Z09ܝhTln!^Vq!2=q֚is;ZzP9(E-; 4ƫ~']ѻ J5%%G]hhaSl&^; m'lE)ṋ`W[cn'~o NR?~#V*Y 6? hDIž!->fb Ҕt>ޚ@hxOwؘYQ|W|";\ڍ8nz $0{䡷.%ד>l04.W t|nN|џӸM:Vk>FF/;Ti˫^oGE Yy<| #}|= ؾ+n4l&Lr >fh|"t ހbu~f۠0 .>43HmN<,ZԩĦettIiWWū3^ZׄIiqmW5:U'IF|٨ؾ+lov Gf7xM.'}O.'߆b 䉉O6jw/gMT:hԬ?@XRt5חQ2])H~S@W|Wݺ?|3>Gto~b/Q0a~KD𼲏D]LHa7i7^]^~fT:s[̎~~BC㑝nUpFRYqT0X~H9kV;YUCVjbᝫKgf=}g/xNu08ekEҫRuӓqiI9,>:4P֝,rk)4/8ct1G:'<:!k,YiDŮ:LnnTruo/¦p[r?+7bԼ-yoU*mEbϥ•3G l-g:;^dCu%*¢'Qn-n]RUa;(JS[$ͧլhZ\_ErMRcrԲ:`wR;=jKZ9<8ƏPeb%xMƓ%חWY7ZRK4W6^Z'4FC$v^_6:<Lm:OH11r/mu̫˱=^h]9 hyn^;inXnn)ύHl_6\|#4:GFk+pF^gG#LӀ0薼?lՂ|#zUV:>xKY)ħ>f_L࿄u=Y?GO3:i:[[x-^WOCS͚3o0@tO_6x-&#m-gFn(-|{~͋mz'-?RTSkQѩ ~^/:f^[N|yџ#?}_Ҹ-BMy7ZWkd 'g)HT96#T=?#N֪<$ӿMm-,fKN6OGf2Mym[{tsh{܍F嬾(2꼦DMڅ{kV2)mN4894ѧc *7 7B:&p^B bz3 Wln*yMoT:ʅGZiBRU)6Z^tn99Sֈ.^Gto{Ӟ6~|Jқ# ^WȟH}zޚcs_"}!zc3>Gt{a;~ޠa3&L#^*'KޑU:GsI31 ~~BC㑙ѭZXa5vªڧy&6Yy o% ԜVݩpHi`9TǙ4[g,|YVmҜwm9Mq^MQS esåomq8O#Q/'SK&b4CoeTk0XS/w[.]u{Ғ?!_av,zQ[)^#4z^C^!v,Q[)^#4zYpg*z_d'0H/ 9_b4ע|OjMQ+;}ޘfgF|_i.>3o#0@qA5G>ӛr>DFת<$ӿMk8--1% ӥFu?#pڢg:w鷟z>#<k׵ yu);FMUJw!e|U4꼦Ret!yJvժ[ۑM䲖|HmeZ åZQxӴ]"jo~[PRrri9oZ>XUSaX^,U >IO$SR\T'ܹ~:FkD1|ޛ|?!OR%ltoȏHztjm[6#?^FtKF3Zl䥣}|ai[߽+EGz7Jm:{䣍Շ%&GJMPn>T+䏢}}ޚ@h$7Fh$7F6PF؞zgCGbz:sy~}3w䡍ֽუy~}3w䡍ֽj;J>iPmϒVH$34E$i_0iBx5G׼_u,?GO+{0<@3J:W6=7RҾUMpnzoz1鿘?J=4䋉O6j $\OIPn? jMI+?FԀgF|_=);tgzsҟ#_a~o#8` # ^Su$a+0қT{Lnz+O>Q@Lftgz33>Gt{ >fqQ0_~KD{5 8''2GsI31 Nw۝̬JZ-H9<^qcHVuFUhs$$맾;NF_4N^p1*7ѵrƩ:#QNM<O¢'Q`+b2æT5Ssݛiũ\rWq'V[oeN _Fw'Ul1OU):RWt.Փ\CVT}mг]rci[o˕vS anc]>+)lo+ <=fǧJ8n~{}fçJ8n~/5FJ#_kM!ҾH'P䕦|M1IZo/T4Ӡ~J:?5fӠ~J:? .u{ӝ˰>˱=^F/GO (c}*5FקJnPmtf贏ё6_3@zGF$i_p}4F$i_p}4~c~=F,?GO3:k䣥ޘx]gM|t~ݡ}Y65Bްz>H/ A_b4ע|OjMQ+;}ޘfgF|_i.>3o#0@qA5G>ӛr>DFЪ<#ӿMn'Y|vΎچJYRΎVNS@<qfz6|AwofUlMJr4VUt x{._zd1|Ms[fӣ~DzGWmr6#?^FtKF3Zl䥣}|ai[߽+EGz7Jm:䣍Շ%&GJMPn>zi ޕG>M n4?VNm?VPN(`z#HOGW3䡁 #˱=^9Ѽ >;P^Ѽ >;P^5fL%h_4{I6g+@{@Pnt_F ޚcs4ϯ^4~x5&G׼_u`ynޕ-t鿒zkMt{\޳Lnzoz0m"}MoG6lۢfqQQ%S:hϨbb]"|?`9@). gҊJBbϥ•3G>_(~O`> p|cFcʕJJH)-E;J`(rmpiaTN6RUy]t=}wJ+)>F67y}?۟#\>G%_$}~7zWD_Cs߯^7:+MtGGftGG`؞zsyvޜi]:7az:}gCQ6=PwTjk4G~QI?FF77#LY77#LY @|SFF}`f:}_%/~?GO3:k䣥ހ zAE1~j $Z6zRjD^_Ԁϑ>3:3wGO t&wK|i_r>DF{|Q"4Ѫ<QN{ ;Bӱt~] CjLmju{'Z.4}L(s3O-s?r΍GhѩEZu55M3 ENx)b,Ez5d:)Syv:kUSi8|,WRQ F&+޳#}4?Jx([E4ʼ]&oZ uܲ,gH&Ehxj]4duZ+T,U;6Yk+x ՞f"aB ;+:UBJpm6f\&d[Su6KU% toU+]uNO:GUұiҪj޸L>ˠH_=F`9HġK5B{\KyJsmco_l:y78T~IڴZ޵UKiw DZ饇X΅C)Kܻ +MQ'jUսd @04ؖe^+UjԷ5fE\n6|/g k=ZiM<XV6-N֩n| -Z=&o_'U.%7:*35:j+IT]rR| /:nھ>#tJ_4`'÷ލ||Ac֜pH__5դbVU9o{gjiiQQY+UZСO;jgB\ODftkwYI:qjtVOeXNQk |щnowQNzQ>ǷNETKKV[uUTmN6UX:iBL>e{jvmMԙx0E'}!ouQMVھ^Tx*5:U~I+HS GGEX8:{Ei9NG4Tf7vm\[-qU-zE7i?_?Ff,2ͽrrۖRwfF0ˆR=+aǰ+V8Io$y1}fvJz[FJ5Ʋ{ 88,i_ƿ$konl{2[¶.bv+ IŪV`z’1ZޕLkq$c_˙ }"_Éz`^[n!xao#1Ȧ֋ETs;Ղ׊]ce4f58WM3(tQy˦)G*011+0E6iTꪧSyZUғCm~x?zV3a*6nt4Zmمꚭ|M5Rj޲pm:5:?5jQԪZ8q=^GOmovSN6Ac&pӳMt5C[^SUU̖.#}xgii#4G~T>IiRꔷ,m #MYiXBM;je ⺟Xߤ5M9v,IšST>+}5n4tvt3}#ޘkNv9HĩN[̀P~Ozfھ>"U8J azBD5jwN.rk+-? ѩ5j:N- jRT>gFRGi>ھ>#tJ*UR5@'#0a-IĮ]OZ#w_rDiqquUI7S Ҫ<OIib,fz 0q(:kjZtE`ۗvnNγ,̴ln)8ܻr{peMqӪ<g_p-!U[UTS9OhENNkiMG='4\7z[_к{΋`]BKZJS98f>a66 nq+t:UWFI=torZ-:NjëR5M{K܋DѴp4ZhiE3 Z w杣]>ZUQ`ׅNuW9:=4k.+YQU73t&%NSi Y&Ӧ^fN*1*p*Uc*wDzyipӉ tX}7RUUn)[}MWt=:XQBښ;Iqf㠣zJziRF)UCқmo@(?=V0*:G}W+8Z'Az}:.h; u(zѬhūXRUjjm4i鞒ҴҴ~XXzVU+FT0Ujy;vКTIҫq11+]иyҰin VSRoQ6|Mqu5 GN7EVU=ZugѴDNiUJާ㢞{¯>V%T&5]7Ki٧3z3MZ{aJmӇku)ޑSbW5)J)9<_pNӨ&t pv֩$gGDzgE0.N)mOj6?5:F'B6 UUF?sEI'gMSi4~LC%JuRw^z7 L  *UE.`l:&#[)ioSΪg$0_Gvx  jW;`NF>MnWn%NFњ*jubUUN{t6^7FQN5IoO{X51ãUnϨ9ZX8XIuiV\ӌ7KӴ]'xؕTNcAѺL4 tg5׏VB'yCixZ>x% %O=':C ; t ©K}Gt8:-/NeCi7Kɧg+ tn&QNU.6^&..˙t:iNYzO4}+Lj04I, )bbeSJ\(MSm~^bbz]N7E.nQ'f<- ǗJAh6tu(\/P{{CUCS*j^KUT. ǹfҸI- 4á^>= ah=ZNF+HaSj)ʹ+HJlEJ'v;!ژh)tӫE}N%UUJyހZߠWA:3joZz۸ 6[=7Bqchz3:SK)F,@S'MiXki88Sڶoo1~-/Lt cNV۽DtN*Uv ׌JO[|k6w\GtFO>S:3VGԪ"VMEt] KtRTI;?]?UV#kF{|@ax?t.դ<7F բTSl4z?z3A6}Ս]x5bvӴr袼M Zupp5M4al*ծF2xis.iW #LM6*]4S$ Ufvs})xQ]tPÍWY:і-:Kx)ZNNAtE>F.&+H]%MVjZگHQC^F>'|#tSbP+ŦM{U tI-3O:7Dvz:t:ޜޡGp2Ұwt6ãKX^>tWItjūC*xE13ި;OкJQQiخh/5J`Şє*>OF=:5:NMnyKϬi=m+G7kxt~<^= q6-Ѣh4SOVU;7]XZ 8pzxԺgި4d:qM'#Y=Jj6z&9hh:fEjU=ܼ$0t#FаGRJ p}ˎ+ܲJ+Cu>MUҫcwVWWET SX{:5;]B=+E[ar[nu-jSRܶZ<Nu㾇M.^FT|[@mt\n} ޑEV7?@NLF 1)UTs;B`27N6gNͨjCF/JU©jVۅ S`ӴL:pt+nUt`U\puѴ4U]ˇR4ӪJ8r<-VcZtՍKSJWJٷ-\(' ՋRDU~NEz_DCoU_Tktn_H.n+T5;%0J]B`ޭ+TܣCLuQ)ښ;lt$tA],ZN84>>M{Y]xubQӪIO3:D1'GѴJp+}ӇC=U)t GJƣ5*TӬ*^n.!x=2ElUSht`:<.§L:XUWRrl܃EVZ+7~})it;L]SSVԚjlM&tƝ/N*4lJ VmyԪ<Yկ]Xuy*t .4Jj#jTՉSO7s&;JQNM'08=ZUՇRTT~Vm#H[Zu:PĮi4RiNYHѪį l:.:ů^%UWSUM,2 3 FEJ+'xVkŮJb+QrR1tg*u1acb**t .tJj'kTՋSO7s:f&q0[J}pMU:u6GHt(qӋRK&b'b׋]XSu[rsi:Lm1cvҺ geqqpJtG)uk-.u?A4}*u޸,®::_5\9df%.Z}5bTM,\ECUTn])VtT*kZz4Ej<.2h-7iIƦwSN-i.V&~~:޿+Xuu/Ug<":4`f>խ^-Ioĩ-KM> C9UKj=OHx8᷽StzN6%}5U/6c$ۅvsUPjN`~ѩEvJqįg]Nl)u\SKJ_"fSҚ} )ұ\-k1!F㚨V'zF5XW[ęu7T%Lmkݴ[*TVu^T[q&-8.qyׇ;+tƊ W1xE'4zu1t\J=;J£gFT'<8G3)M>X,-k(MXjzY5iUX{*^^AT鎩8=ZUՇWKGLĦ+qjՉSO7sIћ&*tE ,ǩ׋]X=VOiӴ0TӇ%J +xaʱ*t,|]|*éy*t +n6U^-^zOIћx87Ʃ׉]USu7St1Km;d@8214+xмX:| #Gz8TK#^5NJ@ժ< Z0p׉ZΧ>'tFWN{K;ޜU{tn>qY:[3#EѰt"(cN-t4ws|/=%ڼ.'IiQKKz*m:Uo ^q%iXZkzn57ZJ E ;J\mҗRRyvIi:&&K[LZ1*Q}z7\ҽȺCLp4\D}]{]{NLiJTR%ԎՏ:WCtOBӢl`^56gE4];Hqx:iBȻIM'JѰ1*ODW %o=GMƙchz&UE3S8k:L:z..)k^MTY):#FFTwSJTU;sҞzwKaӃm Wio`}zWIm&0*jRm1HNӰ J0% LԿrޓEZí,=EVxʎ M+OFũ,=NSJK8`MccNQPwڙtLoHtn&+LVN3z['_܏kM*jtCY'=%At¯ ֩`a,=jq7EEtJaэh 5JPwUs~pҰzSJpL:fO讘]ծֵSªs2:C܏O*Ī)ѪUaaSMTNB4O_E5ܚʝ ԯtGrtWAw{z>>EXx4M4T*S:{9=z{}u3 z2\,-&3Xmyx#:S)pvtv&iNTR`ix?+NE: 4ՁUTU/P[~&<=T*kOܣzSj-}j ^qz +G(%jgSTƷi^}%LnjRfӥp6m<*pX*] ̺1?ܣO,l.>+Įl5KpiiNJ+>'n-܉TRtZttJKũnB\Ρ|$z5iTaӥ`cף<,%M4ZmojȺCJҨ-ҵRN-Ӛ.mBUTTRSTY{}5: <-.=JU:O8Zf iӪj}-t^GGsщV"Q}j ֪< endstream endobj 1204 0 obj <>stream endstream endobj 1190 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.077 Tw 10 0 0 10 70.8661 724.8299 Tm (\f\017\020\n\024\f\021\024\n\017\016. \221\035\036\007\031\036\021 \024\021\ \n\036\021\017\021\034, \004\021\024 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\007\030\031\020\017\b \235\024\030)Tj 0 Tw (-)Tj 0.273 Tw 0 -1.218 TD (\n\026\b \215\222 \f\030\024\004\027\t\036 \024\023\036\030\026\006\017\017\ \002\t\035\017 \r\t\023\024\035\027\036\027\t \035\017\001\034 )Tj 0 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (21,1% \f\035\031\004\026\036\r.)Tj 0.299 Tw T* (\202\027\021\017\002\026\022\021\036\030\017\026\035\034\027\026\016 \021\ \036\030\026\023\017\016 \r\024 \r\f\036\b \f\035\031\004\026\016\b \002\ \t\035\026 )Tj 0.143 Tw T* (\027\026\004\026\021\026 \r)Tj /Span<>> BDC ( )Tj EMC (\023\030\036\007\024\023\036\030\026\006\017\024\027\027\024\n \023\036\030\ \017\024\007\036. \212\035\017\021\036\035\034\027\024\f\021\034 )Tj 0.204 Tw T* (\026\027\021\017\002\026\022\021\036\030\017\026\035\034\027\024\005 \021\ \036\030\026\023\017\017 \r\026\030\034\017\030\024\r\026\035\026 \r)Tj /Span<>> BDC ( )Tj EMC (\026\r\017\f\017)Tj 0 Tw (-)Tj 0.264 Tw 0 -1.218 TD (\n\024\f\021\017 \024\021 \022\035\017\027\017\004\036\f\022\024\005 \f\017\ \021\031\026\006\017\017 \017)Tj /Span<>> BDC ( )Tj EMC (\027\026\035\017\004\017\016 \007\030\031\020\017\b )Tj 0.193 Tw 0 -1.218 TD (\017\027\235\036\022\006\017\024\027\027\t\b \024\f\035\024\032\027\036\027\ \017\005. \204\017\027\017\n\026\035\034\027\026\016 \007\035\017\021\036\ \035\034)Tj 0 Tw (-)Tj -0.021 Tw T* (\027\024\f\021\034 \026\027\021\017\002\026\022\021\036\030\017\026\035\034\ \027\024\005 \021\036\030\026\023\017\017 \f\024\f\021\026\r\017\035\026\ 21 \007\036\027\034.)Tj 0.101 Tw T* (\211 \r\f\036\b \023\026\006\017\036\027\021\024\r \f\024 \221\205\215 \023\ \030\017\n\036\027\016\035\024\f\034 \024\021\022\030\t\021\024\036 \r\036\ )Tj 0 Tw (-)Tj 0.306 Tw T* (\007\036\027\017\036 \030\026\027 \f)Tj /Span<>> BDC ( )Tj EMC (\220\021\026\023\027\t\n\017 \f\026\027\026\006\017\016\n\017 \f)Tj /Span<>> BDC ( )Tj EMC (\023\030\017\n\036\027\036\027\017\036\n )Tj 0.27 Tw T* (\020\017\007\030\024\017\n\023\031\035\034\f\027\024\005 \024\002\030\026\ \002\024\021\022\017 \030\026\027\036\r\024\005 \023\024\r\036\030\b\027\ \024\f\021\017. )Tj 0.35 Tw 0 -1.218 TD (\203\036\f\n\024\021\030\016 \027\026)Tj /Span<>> BDC ( )Tj EMC (\023\024\035\024\032\017\021\036\035\034\027\031\033 \007\017\027\026\n\017\ \022\031 \r)Tj /Span<>> BDC ( )Tj EMC (\021\036\004\036\027\017\036 )Tj 0.259 Tw 0 -1.218 TD (\030\026\027\036\r\024\020\024 \023\030\024\006\036\f\f\026, \r)Tj /Span<>> BDC ( )Tj EMC (\023\024\f\035\036\024\023\036\030\026\006\017\024\027\027\024\n \023\036\ \030\017\024\007\036 )Tj 0.2 Tw 0 -1.218 TD (\r\024 \r\f\036\b \f\035\031\004\026\016\b \r)Tj /Span<>> BDC ( )Tj EMC (\021\036\004\036\027\017\036 1 \007\024)Tj /Span<>> BDC ( )Tj EMC (1,5 \n\036\f\016\006\036\r \023\024\f\035\036 )Tj 0.037 Tw 23.244 17.049 Td (\024\023\036\030\026\006\017\017 \024\021\n\036\004\026\035\026\f\034 \235\ \036\002\030\017\035\034\027\026\016 \035\017\b\024\030\026\007\022\026 \ \f)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\017)Tj 0 Tw (-)Tj 0.104 Tw T* (\024\007\026\n\017 \027\024\030\n\024\021\036\030\n\017\017. \200\f\036 \ \002\024\035\034\027\t\036 \027\031\032\007\026\035\017\f\034 \r)Tj /Span<>> BDC ( )Tj EMC (\024\002\036)Tj 0 Tw (-)Tj 0.07 Tw T* (\002\024\035\017\r\026\027\017\017 \r)Tj /Span<>> BDC ( )Tj EMC (\021\036\004\036\027\017\036 \023\036\030\r\t\b 10 \f\031\021\024\022. \210\ \f\035\024\032\027\036\027\017\016 )Tj 0.015 Tw T* (\024\021\n\036\004\036\027\t \031)Tj /Span<>> BDC ( )Tj EMC (\007\r\031\b \023\026\006\017\036\027\021\024\r: \022\030\024\r\024\021\036\ \004\036\027\017\036 \017)Tj /Span<>> BDC ( )Tj EMC (\030\036\006\017\007\017\r )Tj 0 Tw T* (\023\026\030\026\023\030\024\022\021\017\021\026 \023\024\f\035\036 \023\ \026\035\035\017\026\021\017\r\027\024\020\024 \007\030\036\027\017\030\024\ \r\026\027\017\016.)Tj 0.061 Tw T* (\205\026\026 \030\036\023\026\030\026\006\017\017 \030\026\027 \002\t\035\ \026 \007\024\f\021\017\020\027\031\021\026 \031)Tj /Span<>> BDC ( )Tj EMC (\r\f\036\b \023\026\006\017\036\027)Tj 0 Tw (-)Tj 0.119 Tw 0 -1.218 TD (\021\024\r. \221\030\024\022\017 \030\036\023\026\030\026\006\017\017 \f\ \024\f\021\026\r\017\035\017 \024\021 37 \007\024)Tj /Span<>> BDC ( )Tj EMC (142 \007\027\036\005, )Tj 0.313 Tw 0 -1.218 TD (\r)Tj /Span<>> BDC ( )Tj EMC (\f\030\036\007\027\036\n, 79 \f\031\021\024\022. \200\026\022\031\031\n-\ \017\027\f\021\017\035\035\016\006\017\024\027\027\026\016 \021\036)Tj 0 Tw (-)Tj 0.15 Tw T* (\030\026\023\017\016 \023\030\024\r\024\007\017\035\026\f\034 \007\r\031\ \n \023\026\006\017\036\027\021\026\n \n\031\032\f\022\024\020\024 \023\024\ \035\026, )Tj -0.021 Tw T* (\031)Tj /Span<>> BDC ( )Tj EMC (\022\024\021\024\030\t\b \002\t\035\026 \r\t\023\024\035\027\036\027\026\ \f\017\020\n\024\f\021\024\n\017\016. \215\030\017)Tj /Span<>> BDC ( )Tj EMC (\017\f\023\024\035\034)Tj 0 Tw (-)Tj 0.214 Tw T* [(\024\r\026\027\017\017 )0.5(\r\026\022\031\031\n-\017\027\f\021\017\035\035\016\006\017\024\027\027\024\ \005 )0.7(\021\036\030\026\023\017\017 )0.5(\f\030\036\007\027\017\005 )]TJ 0 Tw T* (\f\030\024\022 \030\036\023\026\030\026\006\017\017 \030\026\027 \f\024\f\ \021\026\r\017\035 53,5 \007\027\016.)Tj 0.697 Tw 0 -1.218 TD (\215\024\r\021\024\030\027\t\036 \024\023\036\030\026\006\017\017 \r\t\023\ \024\035\027\036\027\t \023\016\021\017 \023\026\006\017\036\027)Tj 0 Tw (-)Tj 0.738 Tw 0 -1.218 TD (\021\026\n: \017\f\f\036\004\036\027\017\036 \023\026\030\026\030\036\022\ \021\026\035\034\027\024\020\024 \f\r\017\013\026)Tj /Span<>> BDC ( )Tj EMC (\227 1, )Tj 0.74 Tw 0 -1.218 TD (\023\035\026\f\021\017\022\026 \030\036\022\021\024\r\026\020\017\027\026\ \035\034\027\024\005 \023\036\030\036\020\024\030\024\007\022\017)Tj /Span<>> BDC ( )Tj EMC (\227 1, )Tj ET q /GS0 gs 217.7376464 0 0 181.4173255 70.866152 353.8053269 cm /Im0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0.767 Tw /Span<>> BDC 10 0 0 10 288.6038 353.8053 Tm ( )Tj EMC ET q 299.854 353.805 164.877 181.417 re W n q 164.8778448 0 0 181.4376275 299.8538208 353.7850287 cm /Im1 Do Q Q q 70.866 187.485 147.402 164.32 re W n q 149.8553798 0 0 164.3196576 69.5508198 187.4857013 cm /Im2 Do Q Q BT /T1_1 1 Tf 0.759 Tw /Span<>> BDC 10 0 0 10 218.1867 187.3959 Tm ( )Tj EMC ET q 229.275 187.412 147.401 164.393 re W n q 149.9518586 0 0 164.3931599 228.0384086 187.412199 cm /Im3 Do Q Q BT /T1_1 1 Tf /Span<>> BDC 10 0 0 10 376.5951 187.3959 Tm ( )Tj EMC ET q 387.683 187.493 136.726 164.312 re W n q 136.7265383 0 0 164.3117204 387.6829529 187.4936385 cm /Im4 Do Q Q BT /T1_1 1 Tf 0.046 Tw 9 0 0 9 70.8662 176.5959 Tm (\022\t\217\210\b\002\220 1.)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf ( \222\023\025\021\025\006\031\t\013\025\017 \t\023\205\006\026\017. \026\ \203\025\031\021\024 33 \023\031\024. \200\025\026\202\021\n\016: \220-\013\ \023\031\024\n\006\021\026\002 \023\025\003\f\n\003\026/\023\031\017\013\ \n\016 \025\016)Tj /Span<>> BDC ( )Tj EMC (\005\n\023\022\001\025\004 \202\032\026\021\205\023\002\032\021\020\004 \ \023\025\003)Tj 0 Tw (-)Tj 0.124 Tw 0 -1.2 TD (\f\n\203\025\024\n\027. \201)Tj /Span<>> BDC ( )Tj EMC [(\227 \225\023\031\202\003\n\021\026 \033\032\n\003\031\204\021\n\t\024\025\ , )0.5(\t\205\033\032\026\023\031\027\026\024\n\032\021\020\017 )0.5(\026\005\t\203\031\t\t, \033\026\032\026\032\031\013\024\026\023\022\021\ \020\017 \026\005\t\203\031\t\t \t\033\032\026\027\026, \025\001\025\n\032\ \031\013\024\026\023\022\021\020\017 )]TJ -0.019 Tw T* (\026\005\t\203\031\t\t \t\023\031\027\026. \213)Tj /Span<>> BDC ( )Tj EMC (\227 \035\026\033\026\032\n\t\013\n\033\025\006\031\t\013\026\002 \t\025\ \202\003\n\t\024\n\003\025\002, \032\031\027\025\016\025\002 \032\026\021\ \020 \033\032\n\003\031\204\021\n\t\024\025, \030\032\031\021\025\032\n\027\ \026\021\025\031 \016\026\024\245\013\026 \033\031\023\022\027\025\n\032\ \031\013\024\026\023\022)Tj 0 Tw (-)Tj 0.03 Tw T* (\021\n\202\n \033\032\n\t\024\032\026\021\t\024\027\026. \214\t\024\026\021\ \n\027\023\031\021\026 \t\025\t\024\031\003\026 \030\023\002 \027\026\013\ \205\205\003-\024\031\032\026\033\025\025. \216)Tj /Span<>> BDC ( )Tj EMC (\227 10-\031 \t\205\024\013\025, \006\025\t\024\026\002 \032\026\021\026\ \021\026)Tj /Span<>> BDC ( )Tj EMC (\f\n\021\031 \027\026\013\205\205\003-\024\031\032\026\033\025\025. )Tj 0 Tw T* (\210,)Tj /Span<>> BDC ( )Tj EMC (\200)Tj /Span<>> BDC ( )Tj EMC (\227 \023\026\t\024\025\013\026 \013\n\204\021\n\202\n \030\031\f\031\013\ \024\026 \025)Tj /Span<>> BDC ( )Tj EMC [(\033\n\023\021\n\031 \016\026\204\025\027\023\031\021\025\031 \006\031\032\ \031\016 2,5 \003\031\t)0.6(\002\203\026 \021\026)]TJ /Span<>> BDC ( )Tj EMC (\f\n\021\031 \021\031\017\024\032\n\033\031\021\025\025 \003\031\021\031\ \031 0,5)Tj /Span<>> BDC ( )Tj EMC (\327)Tj /Span<>> BDC ( )Tj EMC (10)Tj 5.247 0 0 5.247 484.5969 136.3929 Tm (9)Tj 9 0 0 9 487.2204 133.3959 Tm (/\023)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf -46.262 -1.2 Td [(F)-16(igure 1)47.1(.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf [( Clinical case. The patient is 33 years old. Diagnosis: T)36.5(-cell lymfoma|leuk)13(osis from larg)12(e g)14(ranular lym)16(phocytes)]TJ 0.032 Tw T* (A)Tj /Span<>> BDC ( )Tj EMC 0.802 0 Td [(\227 )0.5(perineal )0.5(phlegmon, )0.6(supralevator )0.6(abscess, )0.6(pararectal )0.6(abscess )0.6(on )0.5(the )0.6(right, )0.5(ischiorectal )0.5(abscess )0.5(on )0.6(the )0.5(left.)]TJ [( )0.5(\213)]TJ /Span<>> BDC ( )Tj EMC 43.466 0 Td [(\227 )0.5(laparoscopic )]TJ 0.033 Tw -44.268 -1.2 Td (sigmostomy, revision of the perineal wound, drainage of the pelviorectal\ space. A system for vacuum therapy has been installed)Tj (. )Tj 0 Tw T* (\216)Tj 0.021 Tw /Span<>> BDC ( )Tj EMC (\227 )Tj (on the 10th day, a clean wound on the background of vacuum therapy. \210\ , \200)Tj /Span<>> BDC ( )Tj EMC (\227 plasty of a skin defect and complete healing )Tj 0 Tw T* (after 2.5 months on the background of neutropenia less than 0.5)Tj /Span<>> BDC 25.311 0 Td ( )Tj EMC (\327)Tj /Span<>> BDC ( )Tj EMC (10)Tj 5.247 0 0 5.247 316.3271 82.3929 Tm (9)Tj 9 0 0 9 318.9506 79.3959 Tm (/l)Tj ET 1 0.68 0 0.12 k /GS0 gs 70.866 353.806 21.907 21.907 re f BT 0 0 0 0 k /T1_1 1 Tf 11 0 0 11 78.613 360.7722 Tm (\032)Tj ET 1 0.68 0 0.12 k 299.854 353.806 21.907 21.907 re f BT 0 0 0 0 k /T1_1 1 Tf 11 0 0 11 307.6069 360.7722 Tm (\225)Tj ET 1 0.68 0 0.12 k 70.866 187.396 21.907 21.907 re f BT 0 0 0 0 k /T1_1 1 Tf 11 0 0 11 78.613 194.3615 Tm (\026)Tj ET 1 0.68 0 0.12 k 229.275 187.396 21.907 21.907 re f BT 0 0 0 0 k /T1_1 1 Tf 11 0 0 11 237.621 194.3615 Tm (\027)Tj ET 1 0.68 0 0.12 k 387.683 187.396 21.907 21.907 re f BT 0 0 0 0 k /T1_1 1 Tf 11 0 0 11 395.3751 194.3615 Tm (\031)Tj 1 0.68 0 0.12 k /T1_3 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\033\030\031\030\213\b)-20.9(\035\231\213\233\t \021\032)50(\b)42(\032\231\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj -51.938 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 23, \023\0221)69(, 202)69(4)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 23, \023\0221)69(, 202)69(4)]TJ /T1_4 1 Tf 25 0 0 25 20.7653 56.0378 Tm (122)Tj ET endstream endobj 1191 0 obj <>stream Adobed     '$''''$25552;;;;;;;;;;   ####''',,,   ####''',,,   ####''',,,z""  o!1A"Qa23q$B #%&'()*45b6789:CDEFGHIJRSTUVWXYZcdefghijrstuvwxyz!1AQ"aq2BRb3 #$%&'()*456789:CDEFGHIJSTUVWXYZcdefghijrstuvwxyz?JIVjm:b`Iatɱh.I+I2Đu ЎPDBU$Vt'oHXOaU104VuZT&H(#T0Zp2v[8xpl'KT%\)]Pҵ_Y=;QNI-BK9N!2]4I4]fh}Jd bVGxZL_%bhGB'ca80\.IDuOZasx^Fv#xUa0ekַJcBA;)'?e-}W+v58W04^X-tj%4-*͜nj=RVV41tbEY 8XbarMͭrO*˒4C\sR8"$(&}K kl^o(..8ܕv5ѡ&ϕ#<ϧ_V0Ur2I2IK sYSkQyxp9227O)\ p-+ OG WEmc94WMW-}S3;eP1?pu=c(Tw]l2֜q `dNؑԥe}F7x8+,zFvF:p]f*1"9᠇zN!z? `8|F[-sj .[ؓKpx,I\l+xܠ$A=2*%i2+^#qZ4sAB$$B 02I, )$K +0$I0! T;"!E)O,ǒvIX%Ad6h*NYFT+_c3 I' 40e ~uW09)΢9olmnޥU'UsﲛKCZ%0WbpZ_Tt!!)߅3eeWX ~+d諎 MiK+AVr±UYؒ]7*2C\ Ge"֘ԅV2Dq Bk\ҫ*HU+wb 4`OaHP!Ee[iVbF'"5NYa]c!Q uӤ\Q+D)%pT\ScedX{|LD&-VR|gMة|.4w=*I_w" SV8v 1+#cuJJQ,!db[Ro1T֒b)8M7-AtdkYX' YBYs̩ryXE6 :TH ;,OV!2tAf!IK LQ{p^EOIRZ;  񺦟qrF_C$ _Qԫ;I择漱g/c c:uTWؓˈߍpn;!k]eT^f7v#@֐ '!f)(֫~}IQek\GKACm% Uˉl]Foy[ؗ#NL)ϵ8@Z[ [#t5o ː@'8iPVWP*AŽ郆c,(Y %xph*5Jr4Nk## 3#aCbc Q5- &,5d+0gqHJ8{qMGcԢasr׺ˆ 2hsCxfVFZwgE+Y0-DrL*Zlbk9K~SP\)eY %Ss6ϨEHX&Cb-7x`Ly#Newaù i5FWZ xG `7zZe{G,;g-s6C۔LFPI"NZ"*!F2I$,J%$IaeXBI$!Bt ~$ѠT\$ScI+Bؓ# ?seQJiUxcz1Gܕnەz#-Tq`Qcj{ʾTû@9Y0FIy_=x,b90!M' 5qԪ~TLcĿ;ѳFkK3#j=N(vsXP By7*%ag K-A+/ZlT +*3ߵZu,uHQbeaeV W9VYLi6PV᪴^zY{*1Ocn cuXVXeOi NF1 QiCJ'HRK5W^@Q\@'K*@RUa\^CfKAUqNT9)KҘcYII 7MN.15T1$d YTen\tpPLO~;"5U1鶚B4*Ez֋Y!D|HY d. z0F11j:S!1yƦg3T 8o+$]ָqeqXhZs U.!Iw/DkUʥfu(,Jd + X څ$88H)%MR8QM'/~V@T<M4ҍT8 tj/yw4ژ3d2e' mO<"nl|y,k!] IUC7'M[pEk&)}aZFbnaK>C߭pܙ6E+Æ[I&vS.h5-o^۴O[?e' {5NdONA=%ؗb@Xf3sOzXsnD}+m,f A+-t5L4b@jq<To v(&`LSj$ɧvQJO>Fڂ =g%ߑf=uTً .k,Vdun}u{yOɏpf'&@-iRvbEU~u|u!eaeRmRW=t*H ,B̩ TzC¬oڨX( >{ ]' MϬpAVuV7ۭ@몉*'=UqSZ^5HRqgtE,U\4FR`"{И)*rذ.<|H&UWRĀFMo5kBxÀ8 U8j@j1^d&ZbdЩLhڲ&M֯0=@ 8y2@iaԙ>U lY4U Us0g+6ƫ7YLv6bW:U|GQ3-6otictG#vj&@[#,kY8JɨPqU9(btX}(9k[P1zwx ቖ%5+\1#^ۉJFu*"/,SͨDM `qr/C' cq1V$QoWTE|E\渪. Rq6[| QTpGD't[ls+\$W,Ԯa;z>giU)|ǂL38w˿v ~ln?;FW9wWV۪ ۵'njq;? LmsYF,! |)6sb՚J+ZCs|)aECŒ- {df$ г_0Tlo!|2 襄16b:ԛ' 5  Q9p4[\ 8mqWeIĀv)4+ A֋?q#)TvXk@!hpx\N);r t2ZKIcWQ5规rR{NЧ3Jd>-g3X+ %NpE"LӬw XyҁP' t `ִZo{.$뢯)'K-Rn):#ۊyfsfWA6[gq UOc\nʧhO GM*/YXèmJnI]tI]tD)+uNwFDӧ]фDRA{z0T4z@hSb<7U`'o2K6C U%&0tۚ䵰zTO=ě'84kC$sE?֮c}V->3qN P`Vũ k܉%'jJzL*+-UB0\ lK{J*)I9jGJRmiGԠ<B$MXBc'uaK^B/f|*`̨ ]&h|Z{h$X aM8vZk}ʢAAb?EDAEoxn#)V+B㰱m8n&"NYNFz͙ܫԫv|:%n'Z> ff E A]o9@HӚaU &jJ=K$[jcI'aKuٽcaGJYqxGv7 B;-&e%ۋWqritg:+ea LFm{@Kp1 ݆N!ƜbWskC{΍q.,Zpf-{D<#sj3 J%@\dų$A{^Ə9aԇ,r:-h"T\zB-ѐ24Tz x%Zjcq/ &X3y7 {kT,HYP!t"44lN-2D [|8#KOh\c2or2;BʱŮV~2|Ch09iUn 4:9"WAn,,dB'n9BSWu 5;@f}m tVF1âbq  7bIZ>?3POJmcAZciM12K)2h=ed@<ղ&ޫTm*#ZbLcLJ򟋩Uܮcjh YJXK RL4)By|Z{,#*%Bw0CkVPTJH9B`\9pEhY^MYq*AПA (4rd5Qte1nmE .w]VsSf *đe8ܮDt?l~ XIdȻEaVÄ–ilJH\ 1hh@{Z 8ӤR7tG ̒f̀Dgƾj8;VIDK#9@a<6Y3Ab;ﾍ] -d-cZ܀ huTb:..D@@+(p6r=kg);I~`0ƚKډꅫA8sft.td#b(Ҙq!4KF["q.ރ@g| w_Bi[9}%ڄSpO6HLHrE?\ kE"GNstۣQ5Do@d@ۭ k/pos n|6$Dqw@~pW|VEbo&P,53 X'1ƒsa4][+ @kӚA}tP>9-ч@_HGN'5@u kVC|3CR.ˊCcշjRaELbk x +&f3q&}76tT)„'2@dާG ѩN[a$R`=|N܂O}ށ~ *m]M4iaͫ 3M!gPͽ7(\DIfޛ7W,Rz+gEiq&c]q"F+{ž&Ǘ8ڊu٭u*G S4UkqM[ -n5Z䲳E2V⊮!U{̤X"CeEB)O0YĀ 8YBי&2m͘ g9 NCB vן8~U6I #e<B]&3(2j7VA-EuyVDYfpIv-bP!e!xkoVV|[ ,vhX]SH 7*3ԛ']F.'T6xBMчVj5ϑm_2bq"0iwmw1=sPܕCSZ/f 2@i+e!zRlqaXI4V=pP i#0K vW,k0#CA`"-h0^ܴ=p̵3F6:.`PktUrĸQs1ǁ |PA=R7;B=޵t}Cw\)0cCI/,/vwI[|Qf ΕaƅAA+f#)gQz|)o4Dۡm~X܅ͱ,\J7ᱎ9=|-ƴ86G5yvxxsfc.i hu( ^5K^4XH+w+Ahy53iukF)908M\ M:MNN~ùq3K /s7zQZ> =&4]_]_+px:7t-M}RɊiq8;ִsU752rI#(nP*LuFc8P&[Otq.X ppշ진I"Hf!Vhe\/0A3\SFA `Qx4`,PHwj\AuvحB{2 CEsX:SS{2jۛO8=UZ! ns\[g]: !..cQA3oc@iJ!A{+3Р*\KtE wK;z T&1O7*R27{v)6l5QdsX搤7F´_ܩ fv_rJ%tM/8zK =Vw*zR6JRERIaZAEzY.Qb*7{U8܁5gLoAp7zE"o^cF M@#M@2h0ZIOqlMi&i> jJе5[\LZ%ى[6z䫘f3Z#@\G]V8=eƽĴfh` JSIW淭T֏EZjRV1Df7^z&->%^q N>$;1k2 Qt,$RA!D? X\E"zIYLӕJY=ΆA3uxXgc(ZDFpklr< ǐ@XWE4Bo) a0.;,!#&yurTI8NOQԌⰅ2:ֈfBp27ۘ+StF% 0q<;FPNfwT!A18C9625Uh c  kMi~Ŵa@(mS18l'6dq'8dc]VĬ T>#<.. ,pvVxsqܦFU\3-hsrh7TmL>.>/|-t *X uK ; g+AmHY(.aOZ>0f簵an"fC{[롴&>>12:oj7=ADؼ؍I:n;K2YKr-Y-H_RxMK6:qk ޻tR^ V:EB0e&$IE26nڟ'5ڝ}+|S{\ŵW@1r+ϯqC`uP4[quEvAZњ< AGy y\AҠ1ⰚͮٮSZۘw7M[mPi5G3X5!Qs K&XK (YXLYq[+8 J*B !aH3jj)d McV .7*AsM}-MʣXX) 6"uc)6UڭaVw&hVi>rOEMxR\ .A=%3CwY[բ~''4pfu+"DFR`u*=$\Y--MaXnhݱ"wZ $NRZB0$uPQ Ђ &F@ T\խz3EkV0d->v\Q颡W4+UbV9 ]u27 J­cj35&:UJYLrZgM-Ƶ~JA+~vwLwy^|Ǥ0OI웦gjBdltp5#15ڶiZաM!TsIgo!B)vПEV%$'bGESs>`N;sb"hkN܁PSM)j! e8}p˶`y~yiqJUG@kj GY ) S2b 4XBb٠x PA\^'(c5P<-'5E^_$cXi#Q$esEyV*VV@e%06dj4*ɠX>=hl'C nTxR3̈́:&0da{ K>5Yw0ziI= 0yQQ5SL!F#:M.Id PM.囆fsr ~}d~)ν kB)qCqX,eZ%|Q06$Xӑ\3E lG;ESMﭔ:g?>iMЦ<۝V82Hkl::!E 8! 5飈u{OKdN0P2K;K]Q.v93v'U9ii[Bf,`a :Aj! Nn+h:Au\66 #~8yVL ꔲ&it"Pyp¹A#yXsul\7In1`GWb1oe5]TVxr=p:.\7Biԧ!åb:T AB% 7٩P-vL8I x#5):GB̴@iRV;Er$NH]X7v]ʖ+Ihzj4agSw 42 A]O"L䉇H vg6809o(L TnK HpLtXY +q)K0I45dD\ {xt6uh!;Eg Dž HF/wɥ9ײC0zݮ}0x H~roov*m'ުb18a(`[nCsAihn+KhEl\3 tsze;!xx,M|5PLSd X Vz*[ M%i;بxVh@а Dg,:w4NnD*[ynOR99Yy"l8wY- _p'0tYpy sӫʴWuʖVu8lhs7WtbITo^ҜބXp4Z-܈2JfP["-GQ'[H y5 Nu"D*2 UriT!J{*@jD 9]r4.F@HzֺY";TfRJ ?93W& kC bK!}dbC@;.䘹1߱DBEY*mndG%ή (4,-i;2T%TT]DZʃ epKnhinV9Ğ4Ho842 {uLc[iS܄`Naf[Mis'qJY1p:*H,X " :f:)oԆDttSߩ5E[ui1GjZ%XjDv 瑢Q=ʌL:Ell ]7:@YҴ\cx[W~$fGm*ad` 55k'P,(&zyTCܜځw Rhk@ddrqv!1.xpBbItZ+\̘%mp\7DakZM׃z\^IFV 9xʆ*f4|3a46{QT1 [4=;'5CZ\ScqL_huap>}mxݣh,4nbKHCyni29"M/}KtWƚ&k )yr;4fitf6C4Qh2GJp\3a'ψبA(g H4pyڛ:[=zӗ(۫a̕ Xx  0T<`ihp92 &+*W*#J2\C-pj:&8գjh>lfHl/Uf{2<3"HSⱎ`;I_R-jA<DENj8N]:HB)Wmd;y{~Ţi[,mN.b`Ԧ4kvV⠂./'7LsUyAQZEz\8WUPȨ E^5^w=c `"BU͡p_˦O \ 5 j+Ų;Jo,_cb3!Xp黖 ɉ4(5\K4'BTCw !xc=8 ̛_ A48)q*x'eunXc> EtdŽhIuLY&Qiqt,J % l!ǥż8ۈν( h66J6 m_;nnʌ7M0N!=UV\6fPhJĨ<$t$ o[%w˺#R,dPNk4,O4剑ҐF7tDө"3H](g <ĴiAtcOqv쟿:G$n;5Tqva2742%@(DE AS+_pWCg2Pᆍ .uZMaqzUkПQ8-gA2z7KoAO@QRhy1p=9ᨨt0<>8v&1tuUOu7V85 F"H赚;Jh8>,81;VXiwϖ9OZ06ucoP 76c3cE K.=Pv#NP$ɠYl!6KÃjhb 24Hł}R Y#hzCc1m*Q+\I zBA"(+آ!\w)4ฃA% f0d-֗Ƶи宅 {$uSZg} qC,-pݖ9y5˘ ![~v%0%h6=bЫ7/ip eКc`s\%ӹmxv{H: IⰅ3k Fv<+]MlR/1#Cz'\$vf8<_VO =yt*pKZ'<47䡘!Xfk9;0 q=:,' ,3]t3CHb q÷-Fso^anQ%YA`;WܩԀoҤx|}hhHeE}DZSn^ Գg5lAg\# IYGMGVYGOz[_۱\܀Wسg:;HBUHPOYaZ9Ჽ]\ BmyJԔ _2=Y@'=Q|b5D, )Hlj}d31`ngt=+P5Ri2T(2.!9zU-Sޏp~ c+Ao":&zJwvR5g]ZbQQi|g&EOUOp`K]rY5UHVgq)L- Ć 0 tvG~z^+$ױjD5XBu'"@2٨3꾷E'"@2٨3꾷Y`R4D6Ll"`R4D6Ll"p>U@LnêwpS,0+k鸮pq,#νja6F:LK:e:RN2"9O꒜sb4{MU9nϵ@ t%񑅅T:lz@i$bBC7ğJ&ӭ",Y=jgnĖ)!i`w k](/`oysF) (r],2=Vk.h1Zwc`3ٕ},i 2ycJtfsO>hz=g4{;Ut  { hRf8e,R\7+";*)$9ZwR8vge$) LĂ<:L!O=A ï3Q\mnS &(]{NA9d M8HLGpiiwֱD¼QfVh l0MF+/ϓ&ӵw|8P.Dx>  Vg:;Yk;hs`Z:zVXXG.XUOiKbt8%KsFX/q%8Ul;OHc+ Z;t&uc7RL&K)Uo'h0Ӊ۪>q&$vt {\=@Z\8q#`0A rҚIIg& gh5Zn?+ak{X\S 1 ֙ e\I瘢is[bsPw>,d eQo*EU\:xq$sl&ohH pmXc#,w̪ςj2ƀJ]wSRwS,4`7ĔآYyĥd1Qh$Vs\ Z{]w+ tkj$D8<)"@kh`Fa'݅ n!B&D-b1,qI떼.FE/3Iu @$4touRM{33䱚 z&{)48 c0$'Rq@=`P{Ӆp"gD%hrDp ぜ6/ąoM°kAS$){Is`4SЫc,cßB6 &>&.$J?w>\6vO<)"-^ki bKJfuԟLȁ#UlXf 0tuׄ`+\COMӎn?L$H46@ tRP Q!m4ͩIR=KჾCt649,+"wEW1OWVA`Ι{V;ݢ݃HW7g!`!bsZX! ه0jj1\8td4 ԣĀvq:.tn`nNhݵ--4X4%=pbQ$ ح[B ; oAi-` WIPQy]{ԹIޒw/,I93>*FSLںBp-44Z} U7s[ss(Ԧ:nC]Tt;ӸHA>P)fjPz߱Eke v~^ h7_Ie ȈR-w+1MJ;uxd7 R6> $ۤB5[eC3f_%7#45=I)2GiRv&."' k4֋ZIVyg:[0:)'W:/MljJ{`vk'ςj!N9JVuVMH7XltQ+ E O,eDw :e`Nql=NE'C];شYWxkV|`HI0\/e3u Al?2KnG0q md2s|,tdiuUbd6-uRn@3 pVfXhs+t|CX;2<,sKV356u|? ,622#D MZ="5L@24CE[+:FҰe=tT8| 8Vb恠= 86b9LW\g'{K34fNszCKشbq8֗lSIkf*ə '[ZtJc* Mt$QC+:HbbzS0qrDҾӸGÖ.qkڮ7X0i;;uX8Xi'|Ჱtk@iK/p8mC—E[;Aƣh}-0='9a.+Wb!ƽ%XƧCT0Cj*.8a,7K+0:,1hQD YI$`,[SU0 y>k ky;d9TPֵVN(ya,7 ;dsH0 ^Qg?+@sb!⠖2rno ,nn"kW6h1tO..a"n[na 쥅 ⋶=ٌS&WNwd'$%pbb$sBnޗkX:!RܳS-U"Y[d:bF5QApT":Z~B-N K"0WFgmp-0EHsyùJ>;Nv `7ԪpC%{a[0xJt .`֚nÈ줝Ubm#:'7 otGb'p!boh5 @q~3Kg(0VɼPq3 Sphh`9v]Mu6ָpڮmy꒫=Lfs r|Nh -%nY=)+8vɰrflbZ㇑&-syTmɱ&WTbyvVՊ8DqdNfVqܮcњ"OwGK13NE T[ք 4hR`"NM7==RB6꓍<@14X"?Pn:$缻[o=5ef$MP6NwFЗtzax-e'/r*@M;'d644:j+M5(Qv{TJlƉgQMD7; @Io(L$ Vp mtn@'`:St:qƛl[Bnk$jLI0@ -4Y#RdzLf 6Ogh4&oz{;@ N7U^ձ~pdZV:+}$*Vp}A>`5y.`[iZ|Vt8blF& w4D LǷ+ՉO=ޯYpyBV0& +88dnSj,b1:C=mE/ 7 ɺcݚxYGr$Dت#.O8d4w,~G.Z+J" hs]`mBeHM+"DyefGFhӨz,S;] @xuF؜I+xL7 $g0iMx,\\ediGZie x{V.uu;4R2\#km~DB)F6&-p45ZZpqI#s䝜FHXsD\bz=w– ;H 8ƞQywA Yx"1p֗خ2l:/y!nZ-5#Cs@6 7|0h'U0YީIcZTL2mUI5"6].67p2Y-4-E0|1%ٙل1=S>3^57&Aq]x^%ؠ;7*w~Ps1ڵeE+L=9z@!9>v8MTcoGCPlkKMsH&[ӛV Oz܀ a# 7=Kw6qZuӮj8Lf+pC]Rc)1{Dc\Os#neāJkiZFlb Ы;]~'c:1=Z/A\1<.x\,ėq52uZN!dt %Z6uۭXܶ]Ȩɭ\@RYe`X$;JC77jIsM@-MI6!3s*XYCFY&\ KJ0"l-RvRsz;8G.E*i/zQ>$Pg ؒ۴fA֬p A"tuON{<}J c{ `ݽBYAK":}>C@ZTs5&4t߹'mP$CƤHuB0A5I0=Ү13EI龾$7 IduZ` ;֝3tVTVU*eFnsiǢG af6Lz${p{$ i܀H))&I"U: V0ˀ([u+uRd5[|V& B+&bX`4"[ ;l/0w_=z дoh2@2(X>Rk1hv[L|2 H*tu_q y+˨C=hםsRŽc8:W?\-4c3 Z|H2p-Ӭou,粓:V3+mQ\"ӆ^LZӄڍGzKd GWLsI&QYJk2jkXyO%S+RNbA(|r EYUkgCA:Jgh7Ty_Zd]latJ4BnMloYLQU60ƼyUI13͒qr7t9@z& 7V4GBHv#CENWu]H x8|#Zl]T?']`l:;LLq'ԩw+!mC\ՠ-sAx>-0CAN*`khW8LP]&,w5#L6Vk\{}]`i l\汻`$w\ Yѡ9:"<G]RAX8cIJ?M P]\˜(]/ \‡:G:I^Y=Cboi(@+&y;ή&;6TfW&nI@N)WUi\wQedgnXwvUEW1*pdX|q͆8>Qpt:}!I&;ʂ.#C\uVNw#߄7ҷ8q8]cx f.6oRAsO xL%ͻ~h;gi^;G Dʥ´ڗHc8WBpaѤtZvS`1ݣ6 d]dw[p|64Zioo:SkA{[k5A|`hhKl %l.`yO+,l. ޥk hsA`D5.ZZtVիL:{JK0PvVY8Ÿ^ A \jx\gb5>9hX]Rڪ̢6pqrz* 6^$Q/Ui2b#XŵNͣCЙZCKZEIUK` ;_~0:L]p]45$T2WL`Z304nRy@֜<БvmhxoO=FX*.'QT<#BM5!=4yX'& {*}7Ҿj0u$]U,VG4 -]UM@5'1{E@PMTdd<dֆO_N\NzƫDtĊYPX h*tW(pÁnD'*liH ֚"ɈKQ-u.kA+M(d 3iH *):v'e.O('`鲜#,kKNtuJQE94M^іg8IݺhscHݢL E4I%;HQ!$঴` qjIܪaT+,#8!5Ή'kԘrb`EXn/oڶaHa*<ޮ-6' zӇ j9.1Zllj,84EŏdmyIGq|$iQA؊2z\ʛeHyUmNn) H!sx)m$T18c&9w.&`CLT1FZ`+FcuV\ZYLtr-!DH0]{ٗ7U Ml6t6&P2ƅk@T,UKcEb5 RM=rPf׹MiְB.SX`@Gz4̐yNZEzf^m:U]6$C^ X{ )Q.0M{co;څ @G%Y>zŮi,p@uj!vKBt g&g3R0*AcN16HHA4a2hڢ̛U:r@ozzGhL'JL|഍4Vpu"tШfܕc&? k*%N׿ r[{h 7XqG9o/aeĒiC u*3cʗ$+soe $LMYB v+X\!7FW@iit{X nR&u3ՙńZMh+] h)CR0ی@3iMPRh0ZKr5&ntV5ׯ P.T46@DIyuL&|a !́ f}h3DνRV" )C x:KoqS=L@,D7jt$M+Ҁ2j%F@ΤGܲ0t 똏sf$K:`Qh׳DJNĒFUXn Xt7 A]zѺcib6-@V)5˴*$ =ʒj$U&,@RQ-S֕‰Is5+Jh4!IF= a>X,1&5v4 &4Nd>&.0#I5 {U8ep=޵,az!o^::8_0Vf:o֟ ]!,?\7B@6t!i8}X`ͭ}a" EGZ%ĖT&]X۵.HۭkakVMddϯ =o\F/ .mVGJ` .(>#G,A$l&T'9aZ?a 5n)f{ 3[}+v ۬Y([y=SPW) wCSZPtMN+N뙹RO@u,Ʊkd4KDaLZ hi4lNʳג5 j/w+Q,-5ziGD4iY7Ԧ Ni`/ZZП7 t'&/2/\kI=[ YH-fcc}S:N{tDV. 7Ws`CHokMUϪNܠ6Qe\ZG,,ҩ7M{k: 3T3xLcd7.Cݭ9vҮÒ\d'`Z`*MbLYW{be=ڬlsKZ-la:uF@﷗С]H2H0<#kPadDdcr4ȴ\A].hp$P# k)uUBC}f[2C |y9kȴb하h#˅iu(عXpҷDzC/v`V;GQ! Rg $ɟ]a vs8c"Ǟx7 . 1a6FX^Zsii9c .pL~wDOkAV"6M +=5^Q p ɝ/F,^Vc韯Ȯ㲺G+SӤֲ %ѼAUۍ|`X/ް[|.;ƦCu^'a9kZ8ۯĶbg qqi!X! lY4wo3I" $Á5:O[f5 cppAC[;ŭ4'\N7 5gQ {e ɮ)7)KUh{Gʇ784D39-p\G E8w cIWp4; Ɉ^ijL5iőNOfT ;uv@Hd<%ga1zj;(ܲ5&Gf> KƓINvlvU]\e BLJf $3ײSrIXk5 zЬd{n_8v,- ^[J׹βt<[SV!3 ՋR6VgBPHHء@S,$+7 0XA!" Z:"T3ܠ6z{RLEU4: F֞MT,Y !C[riԦ]1Psf"z%8%afS lnV@B$;( LUe* -&:gU`V/XI"Wj!+I$ aң )$fBX%$J|(I%)eVr^% SI"TIsG }{Lr!FJX 3چVۄ6 I!EvD!$IBI&%d,!NIf! +JIXXI*Yc2R@rd ANV TfJp`)(=uS •ޛG()in+X,G1ĻMF[wPqtuԥVXN Ut  Bun%y=')]ڂ%^s֗[35 ڙ ;Nգ N .GFƱ5Ϊ9iI"'N ;􎄟8R7͉lq] y qx*;pO`'H]gƙ$Wթl p8ic0⍌0Ih`\ /p2ahe qU9,'mй6;By{iL.om(Ʉvvv^=]@V,vp9%C5\3%Ԛj? tTl)<,@׳rNliufHzN×8FZzrr(i-պmho,Nfk w蓨#(mB)[ꆪ8ll7`<=;N8yG8X8uP`Sd(خkLXFTōfWӝȝK^GB[IcC' 1 tq^Z)CIo,!M.Yk #tTl+g6#b iCZ9ʦ#1.3r+&f9gSgq[N##^Z$r%~bAS*x 'CV-=F\\'}oYeObK}YBcw}#hGڦOq=boK<|O On)'- 3l^wZ~/3mJ!q@p:^tN|80I Nk^>X{fa{i،ǩ +xl Ď縏&pA2E +nJ^0M9{R84]J\fj@Z'X~h:F\Â`K=6ZC1r0(WPs y{;ij.u"B|3 6[>8Cס`{5ɑMvZ#{(h)W+w7"WRgPwuwaukvb$BLthecUe&5>A7jRJc `b񙵧Z`5nlgsZt@LxD{%g 3Wx73"rx`uC|^A킷<7֖Ѵ=] ɐ,4WVP'Uclnfjg$ ⨐pC@1IU8/f q [VY.S̘J#DbʋpU0P+f#EP'AQkMsfgTi JM ,+/'Njb4D* +%% Tm%%H;u])&5uѪʑФ5ҢqzbuS"%ʛPՁD 'LrJ+NiHR,ȕ$% TP)I%5RN:Q*0TJIS'@ $(\JjI:*A@jIeL4CyJIr'*&I;+S 3U;,IQ6$EB(EJ-^"tRS2LPt oR%o|X EM߉>e #%bPMԆ: }A2 JAAHQR".RVoEacm\'^Ӈ&IDFmtR- +Q : ; 6zVY5 ֤<` BI͜x80sAX YhkF^ ė㤅Oѡd^H{pmWVvo lO(m' kp y4SG #H\om1(GbYR. H*'k*gc9NIJJy*U" h@rMJ4XԠby2XN'`̧P1KJML:ԫqDVBngJ0#U!ڞL%*a]&O@=(̫ !d5H:I(VDlJhI! ru @$UM(Y m]Uk Y2tVSY VX@DAD()Җ*a *N"T)RԉXSJdfLLJ; ,*Wi(U݆櫲 ݆ 5OiM5B$_v$=Ii!]vS'lSݦ=m*.JutW hIvI?%RO`Tӂm QO7QUewt{*NIl,iUԬaNRJpy$Nɪ$=_Yg 0@Ov Y;)JNkVZܪI%iZk (DHOi]V7RX5P{APY-4[ xmrIh&=N,ϽJַX5Hjtժ*IP#\s%mtҤJRV'tlI8'B5X$Jh(ʙ:@RuuR` &NXBjuPI%>6.תbqIX&lkj$,͓JD,9 $ R4 XIXRܔ]O(gM )6V0'| h;T m2RTmBM EF$Z̤3!`$]I  +JAc8DDH5@vQR;(BRaJmi$2K(QX++:IXQX%` I]RmHX%JV /r2?(QZ,I+">n2)V3, JV!d9H%Oe$dJAP8 JVSFeD,^!`%e+)#2?eGЮ,$Ӧ@Ī +K2d9B%`4Y̢V5Ȓ6$@XʊI:$! YBcm*@A_kSAݪ#dAXUދt,6 v+U));Bpx]lP,)"VL@᝼Me0Oj ,@a]gWVFO0RVPQ ^0HahlȠS' zʮN ,+Z0^MNMR5/ƍr0ϴ2^i-&vXVۀ6B{).&Qf*l@ĝԂusnuX.ƴ$N%vkm#%F=ݕ|g:Rr!R{qԪY_RmHUw"zU]ľ9nxS&}tjE&L^j64M.Trv)u+ۺKuY,DAxe<cxZ2K̒bӥ-$ɯz-%H*<qaIP8$+M0A>`Y@ endstream endobj 1192 0 obj <>stream Adobed     '$''''$25552;;;;;;;;;;   ####''',,,   ####''',,,   ####''',,,zX""  {!1AQ"2aqBRr#3Cb $%&'()*456789:DEFGHIJSTUVWXYZcdefghijstuvwxyz{!1AQ"aq2BR #$3b%&'()*456789:CDEFGHIJSTUVWXYZcdefghijrstuvwxyz?(j74 Y!ݬz1kکk=k7atI!:bZ(L5 ghjϚ!Bp2Quohh4\9dF4SGWql mDDJ+޴ñA›<8IR&T@C@;Tg "B#":XǦ BSHlܚCr(#q]ƔP7ӭ^ {?;^HuLAh IBV=3Ul7DDȞE2uY|4WN;ZּV8āW Pϭ)9J:e)'[ m CSWN/t{n|Z3D4NjdI{ճ n(S#jB܍.-VvݏY٣x dF˵i+խҘ]a5fwP[ *]h9MsXpPJd,en/vn!uI.ǧDXJ \6 4_5 gQ0j3tg.(?i֟iYN.N{Z-d.~;~]^+HѥNAFoGCLEie4\If M(oKhoV1cG@Lmcڢ3+$FLG4fduhJuC4ޘ=( QF2՟b#J<J %TrnJ}kJD3TsIҁ&봆IEg gZi#'(ClMdTzڹrX]T| zr4޲O]c h%-NA8*af2'¯33>T5dVUЎ<_4'Pĵ)I4̕jzP@5SGCK_\J tlM/ :ǿS *})<ҞЭUd5B0HP^jf aqb;3D`Ղ}BiR%BY@Ud^QЋ95TQGT5ĮJA,r:ͧ2,*R2΢UJE(4 :TǪ!޲kVkORF,TnPB3G T(#o}*icHHW*B5a2r١*V+WdjF+c}@nIN=\: y:$q]M*YHSNnkT\Y_aSgZssZz׫*ziKGW1|T(”n`f#T;4#j '„"(?nP XN1J'L9TLzSPٯ-y17"}|ݛL@j\Ϡt,ډ$4 $d-ȏ?5Z{@uOh*&( *FQa@PzJ3[R'{\tOJǧZb^J[g~t߁it|a1/txuxOFt4y=p1I}}:ği OPϷ omƤI_`vECR7KN]+F[;cGT"^d5#XV:4^^O?&tQ7`!i::i5lGՀapә"z{N01I'-9zIQY&vK+Sl ֍M#&ՍՇ-ЊhD@"&6qĈ eH.8U:zvf"Z-kYŲn-G [v3TRs"8Ѩ}Z6ja5 sEl2S5џb}ؿl^aZ7봻H2 וivF(ף-= 8IG50BDOcg6ķiHmԡ3*B)A}j KvNi'=˓TxܜiZ-*&Х")bՋwLZBUv0W 0J K$J D*ںqu89LyV-XO*T)TSgPυ\2n)"! գa=}m\poY(Jb5Է h Z-0jc u?-]r4f- =ʈB}s+R_X=ݙV\Zl%EvNBZHθ~ٯNr]f;H(mX%B&Wkz5~ͨ%9DzمNQz9Әl6䭨2VJWj8++1Oz y٢kykݪgSRFR'~ 64i psExkBf5-U)$O?Obڛ;I&?T=# ]yٔn=i G`7Sqچn Lm9+Zx*,8i5!-Q#hu۵7(dGz<}ցgtLWOvx8(}..hTI[Uzd e< c)7O$.UOZSѤcwFԹ\ko2Ր|F䡛U86$ Z}j{s&-JB'Z"5Ĥk RvvB$GG# Ep%$),ô])%8 *wSh c2a>53pPaXNHsz - p[iy lu$0H@hM*+5chzt\2%ys!WTLl\)`\f|>ZY^] u&4u{@GvxԘ1-iҖhҎ994ne=JQ͜ErdxK8H\¼O]0pkT5b4,J<2LÃq;5)vvi #Y54Gx'G?lu+S!><מCHX#Z͈7 8"ҌԷb#-6mBGi\r+4;^lИ>K[%yoag&a!Uu[aڅ=!&Nkb! Iִl!4>PH Gt-X:f:]V3Ԍ}:\. B2 ڡ$li47{!NҁULDr:]wg> 5EE˓%V³}9B(W .5+L+BcԪxHjĂ2kTSV^)Mbѩq]IQǰO@Bc[t%-8j$|_}O[N>rC{dfvQ!VZ&B$[0f%P^G˴@"Y0NpS w -hNmVJTLCȑ8SPn*h*F̯ush`G=#tf 9H#z0HT9 ,%tas>*!cX ZU*]GSM,[GΙa {!fFmtMԟyZ> oGXNt8nA%эu12cg1āTjRѼ.7l[imaZ P=_oiO)fc6bu"GI0Ks&x@ǥ( Y{:6R #jB( zlՔ}*guX؇2M ;ׁ `OU mS QiC{x?jdzv|f=EnX"<žJ;ZX\ @7J&༎U10-K\H{q< o]l{TԨOKݣЄ8|j7Wb[wjtCT4Ť~:[]4_gWH)O^utbB#-$AɊ]y҅č]? Jԁ v}6lԒ%hR%=b9z]FJ 숐qKmT0SfţKOO+|UFgeQj=}#!-=C <^v/QCDxpz.(g{D[n!JcI5L *FD蜹gݕQB_`qֽ/[lYKkgSYSntԨDj͸\+nY(GD6hsDZs*寤ԏ42^O^嫧?W"P+ߥuX=~U=D;Wi:ehP(<[3& TِZT7ӪDpK QW.FbԳy5mR+[}cs)Y&2{UM1ȭc`Lj >t6o]BQvBoLb.vD`W[њ:ҜIźEJ.nՒm0RU;0FVHAs,Tt妴@ N T_ /ߵoM5MIʭ5"A!6F)Z7BQj'6֞أ8Th%d[~5Fy8\p\ZiDS3rg%iDDn![ K?(LHM_m@l;dm] F]E)i=)C 읟DF}E&C9Pn`v NKdiU`g-4LKZc!#dc{ы<זGVQdA pU={AQۙhf l95)خef7z5* wF(pwF(-4o=]O7iȥu>C[WH@ݧ"}}5,Js3ǴɭT4EgԖ$ kQR1nuh洃%1QqxZƕ5* ˕@D3Kp!<ԩL = !!;XIHqVFUMHD&(n{lUjFuOYfJ#glR"g(L<-ΛAvrLҳ1ўϮb{Ċ]E\ *kRi|`uwBdU\ZD&wgimWX5= ^Ӝ.&9P)%Y # :8zjnc^6T:N9TaU~*M:+X i7-ҭ]v/U=5Hq`ԞVNsbӁ=Ѝ3`qhZķV`=M2zzQԴe1 h$ .vػpHS1(/z*|H(n";>dFC:;$W6"UQ1_ֳ!Y1O= ɻqcGo^ bZٔWjmK-.5q&8EI.T 8zJFR&b*gCJ=W_XTDGP-Oa zCWL=r#Ϻ*zb2֐#d>3An,4~^8s|T8U #B5fL$FT^ӳ2* ;'bbD,:gPߊT1OQ,YED|u LbX zM=r>*n n*-KQ/':g SQ{+nSSphwiГ?>㏎nxzxU%V4: gU4n s糏TKD-22| _PxzC ]9(bTr.@;tӀjZK?V{\a އA л{N*eV) HnP|V5Њ%ևǑ#<("EȄ21S7(q/ƭM gԑ.n̓KHAa;3&)Ę$RJʛ-RK-)HIzzjB:e6Y(gUo=*0ۊӔZm@s-*S);MnzMSwVh*n,G.9𪏤Iьd^dGT?WVk<| :p6jڋ]L1"3'`T@ CWjj;G){6&v٫wjL&`U1G MHrq9CfPMbZ l̨"$EKX:88M ( ͶݓD#O 2~O* >ͣC'sV *8s:\Y;UùTZܙL.sV 9yVA[O^TyS%BZ{D7a +'s84۴HD!~F@ ؅#9\lj̈5 Ձv֨OH)@N$E@I)4['{mM ͭ]?g\9ZQ^w!-YzlcADta8=9 ǂWSk:Y. vŤjCR%j&9nh ŅkdZ K' {T%ތI^VA8+jhnN JuNcD#+Q҃bB4 q73(usUԛYOaԏ|Fl"dxbA>21;w10v)/zii6hNZiP ԛ U?bv-(})D@!GkTںR.DMoy:qS HxZxާ52~#j fG]9A۱S AB0ǚKʗvGvԩ`U:}[KԜ|71VKLY!086E#4^`2R77JRBxd|j_(j_ּ"JM#ڐ똣R`Y@@ʐ*TPtѸl 6050)ST)8++<Qѭ]t>J|fԘx_hTi: ,T|4CxR ˜le v]mVyOMJNJV%Y>,)iU"[T]Q׏#Z{zJ HJ8ґiXY@*vIEF4c+ךĸDHX^Գ$Z Z!Lp $9R*"j =n6W}MQefVhva)kwviFVqV 8Nh4 p2 ;Nj6\K*I >4|GhvKSRՙmDΎܬzp]6iወ t(GNdޡ)+t#٢ ?}zW6UvgP2oCK ssƤ4 9$eYVK5=^9ZteLM7p"gWr\8FÝHث"jsSu-ld՚BZ⧡\ՠ6wT3$iR,4nDV7xf\$QDJIԩ5IdRl#%h>0DƑVQ TPiY5vNslITIJ*Tѵ&NH D2ԥJ*gFse7FH}i:OG͆:[ ЊhGn|aՖ TRsuxہnwӜV RJG 3D1ӻh~bALUMTR*0:btHE)-nJ W֣ҥJ1M&;Z3 h@ڔfJ*T,wT7Tگ @S. zJtZ{&HcQGדV0)uKKLHʦ`$ X05#S[.o))&J{nP>yގuJtèf W@îk%Z' ɨKJQޤ8kO_6"3I7VHUJ 3*'S/c4 P G|f5+FRU(viGW  i#>U;5 .=f 1 z x>wֶDNM8Ku,\eΖ'|zR[h02%og)bG!dSٻ>r9&X'嫡5\tɄ]\tuL`\:hmpǖ,9c[M ډ*EwA;9˵J#ls> i]N@Oj+iCҷCBR2}v;FɌcx!Jm*0GC i!KD Dj7-.Ť:|7h&s2dL3ti֞J[3!cR375[gBl丷YDO&hi:jPg!q۪|C9$yjrR3lVn PZ{,.M*ԔbCЎ+I.0A%FC$PV [Jt/}1*.t $BReťɕ*!zA Ak0ȷpKܨgmBq:$G*z:m^aJ* 8#z#iBƁaG.iRJsna )6%{}7W]'ON#QFR4RV8v&ƴ-T2jۨF(1XIlҥJ-:eT*#BtrSpJuG̞MU`4R\z.kx-]J W%\5#jTRWF$۔+J]چd3U(TRo@KS!Hj޷F"#zTRstJ-#zϒǰࢾ:mDkN}IUGFr2b %˜+WDܶZƘ}&3Hf >is0Pm:N";}HvWWA ^FjhǺ5#n|-[>n'T9;dsOVov`:[4;ɉ @ J0=ƈ9̈́@)׌--j8j.DEupz.9~m}@a hX==Iړ" #GPz"k6u,&@.Qe3җh:2nJIH`}>է}!&8`p!ALN ]T}wxZH9"tׇQŁP=$.*Y>547BQ!1(Gl>fb"SUӝտ_+jj߱ }gFr`ZoRn0ƻ q\tFw؁UԢ60n/i)`[`o,QOB^طj"HW?o+eDE\}!>ݩQ`@~OF\iDY9D<XuZE&ܐNG6 Şf:AƤHn@p`~w$>) U_hԴ4"iGߊOGfLz KY>D}d41c΄CKTBZ>Ts2Id-Cpikh<Ҧ!M trU3LUЈhBR0t"A*Hzٍ(#>ƹc+"75tNzZRS NebVLfOx 3: =C{U)4&lO6.RLNISLiٜ +YլsHR*OIRt ȾĮil':3HSsĔ (ԝ558MVEhe;`PM9Js^u RD !*7K_9- `l󥛎h@Ar-*B"y4⚣9dӘ\;DH w8TN0\7j :z pߑ)X{#`RԟL J@3(Ҷk$-sUbTeE3.tA QטRTjU:@plQ%uG6 DjTR+  Ў`iS,&Xg'=_k:Iِ :zJ[J4uaTꚞ,pv88tm#H3+Te9ҧGJ+P)̉pICړFՠATW{i>8M:L26*h MJԭV & Ke'Ljbt])D TP| 4{<"tIKJ#qJXϤ"Nj>tWR3H$M%z=&nZ2Cd!N "ۚZjmisM"\G":4)Ԥ*0N03ޤ U>5%Bg'!!!oa(#T;Tʌueމ;Ҫue I21?4Ē.6y" cI.ztL섵pj2]r"4Oߤ\atd]$ЌDħ!WA$JZT"Civ:j`[|K8fQSGsSNDoKd?5 xIޑڝapqF tC˪:fKLh*Shlo*)qjGhu LIa@%=OG# {+dP DrxC)>%8MKZ$oȗsk@&DRU]5*Ur+Y?s. S><*JG*T[GΫM;XF4~BFPd>:q??*T$SJt@CŽQQ:miMʄة Ip~**2E89>AT;@FdhB[u'C ʢUb3Pu I.nhbj.Agu(}/Nfl)2;t H{,+ZW*D>oPd{ S=kI̘RI#14PO7^DWu\@J.9XF(1!̉qbCw1&qsgs.y(S;3(gwCjaKәL2-hOcweCc2) F-PMYQμMޠkLTTgimHH^@ڕiLH%\MY!)T]F@c`M:@niH/;ہd(ku*<ҥOJhIE Aukj HDJb$V,uzݚ@Fl˪TD&EԤA$9%4]u'd nc4 #dv$Q-=( $B@U ><|Tā@F_(s:.q]jnTet:eDTI5]Jb-<. cҰ>ԫY Gm֢U[3ujf1Qk-L@m"FsP1Bp,j̋x>^Zg(Hp<f@kC <\7<ՖS?-DI˧)&P#$qm 9Q?L'LA:Ґ%Ou֬ ? jfEHP8^gΈrEIU[K2^D;T!RQ=l>:z4kJZ b[④NL5_/1]$Um$4re~O1@P;blHI\IQTR @P8!+qudWpҢ[T UՆoЍe)|*+7Y޸)%UJ(0}Oyc I"hȝa+7 a1uZlp{ۨEm;SÚ2E- inU[$F3N8UtR|>sl(W֓_\HK ӡ؆Rx*pUNb[v4@B1TGu *9ڛr&7I 9>]OԱ,k?%CLVmRj+2ZdA*ThPT>24DUCS dؖؗP=c1 H@qJp5%ύV ]#IKqQvƀTu ̮FO-MT6+aމQo: "CWejyp<+=\G#GuC{A;gAܚuݨcbPSzY+B}A@9ڃV2C4ő}2GkP6iRUPGϪ82lLon@"V¿xlx2աVXi-&.a 57=8tN֧+[Pm(NseijeEgzѫD6"\bXl I:<-j(hmF;kIؒHnf2MZm*ef?Li ëe0ĸ ԥ!./L iӤFu ϐ;Ri98  TբRqzN <2˵4(] W-ޙlQN L\:4/j& G֫#p=oԇݧ@) nCyPh^nSxcz1!/򚟫18++u87FA4t缙`9&.Fg& =Yu:Uf";ץ0d 5>3$!,Snn.a@ wu"O ;F*Gq\c Og4:N\7il '( tS̖޵*-XGV#deU4]s㬔Om-SiǺCLCh`s$%?iF5|aJ0`3Cvo #0r=/*tk.kA{{сTLϦ5[XZut\ɒhvݞ:ךOCSOډ/Ԫ_g֔ [FfCف#5Hfe8Ib.;,c( Q"iG\i3ћ[Lve7xpO(@864ރPs&HpGnR:5 îa+8Ӧ0^ao*j3AZZTviU5GAgMJ00  8.c%ZWSYxեwBlG@pU.}q,#D='igT]ޑ)E:G2!X8mm_J5~bOtLkAPُ"oMOIڢ)zFV0&AS>Zn좥"!5M6UhjRqI\4k6h˦- <ǧ(qC/k, #  #Gi( Ul9}2(Ki>v]3- ANOg"Ư12iamL"0u {$DENS{2Mf%2wi RX؂EսJ:LcjsnÓ,S[hI$DFghN+xUv|eZ!}C1ZS&+n3=ș{j11.#w]"<P9Κk CL:tRLtL4 H|x{AўE)}n;D5O/VHF*BI])LiKE/W֑ "6 ^b⶝#;$RAd%8{M0w6ik$j0è/ogC^jKV2mԌF>K}ڇ?-5@^fN";85DP}5NdzQC@(h׃[ 9Gx3--\N2]tMWCPıVTY&3~醪DGd֕AnT޷jpsOmF%Ff$[(5@zhbm ժ!cjOT^<Йg5 =8SA!}W3Tk[ Afe g%[`¨K2~3+^j$#X_;Q=]ڒQ;8#JMiҢM0zbVTx8!:`ZbRY쥇aU= h6RS@DLlK, =epu* XJ*U+3MJz-߽v3?6#QQGVIl?9oJ*U^ʎI!N"j$Fĕz-'ӵG4MlRrGƟėVikn) cT$L bejtNgUwkvQ#gWئ:,|ActhM`+;CL#S!SQ=HsMu6 i5!dH>j%K >TiŻN h`qŦ"a6=LVs)lxŒ4!cOռzf[~Ǡz u0z2JViJEˀ7U|OhUEԶ*:ZG:}z6~{O)TZquzEhc-n%tQ ndw= RI9ll)ªT"1'5C4HDlR(!bɢǗ`]%b@;DӺe]ñʔ;D&ΡUJ{59+;|;1ه.LFST4t\ٶp;dڽN֎ڽ\Wc@e^fF@0l˩ij $){( W+P ʊ^b.݈nrdل<mZ,5̀c*lЫxGN:GeM;U FgZm69 42ْp)5T`_WON9'qU`A~ޓtq2]ŶAPԌzn O ;"!q|f-Zm9MSlL4i4fG'p"H8Ǿi@X|٩m-&O'So"mNy;Sn+"f W$xvy.0fDLL|~̰O:٢eNI"H ZޔXpz(*UH!V 0C=ySKC|UOL[pZ ;a >_(HsS.vp'LyZBeQ,*"x 1((l(O1JH\H@JRF}f Dc:ZtKPUƤL+ba[T6(Z1 cj8^aJ*ҰU;8R\.A4bdT)VK ڡ Z5M6j8F*'f)m6հk2sE4uf>Wq KXƋ ֳc:^}E[at6w2uTej`FH)Pl:m~|jjz3K\V~EEc_k }K&[i8DUT^;􇎡O 3گ3+v+  =_!W.;TƬ5JR' ]LFcG+6pݥx+9s@t:׀#EÍGra*i,=ҪfY^s3%n~? ӱV5DŽygDTi3Nqڣ*9ʬ聁O_*Sڭd*Z:jI~?S.-92qRZk Sx~щҖ,D|[HU~ç[@,I#Z?=4a=BS']XC$*hTcK@8JGGE.UƮ.)lkϊX c]J13(Q-p(K2gPt7JuB'c}GViGp#ڦ%ӣգkNX\˶)5w7HJU D>[yЮ= NZ"&x@"KS 7Z* \Av1$`Ʀ:PJ'iFq2Jٲ0gDFAVGz[SJA<ƴGSUnK@xSu_]F舳{T-s$V_{Pzw!}ded~Je:GLH)\.Dr[P ؀/UIJ5fA;I t ]_̤m"횒:9zAQ2=j1d֝./,U=M87-~q лj%! YP0{vC׫]Uet8W=_`_4SnU=odghM`u=M.phu9Cj\^~_[ԾgketFMO2F?E(L.D\cRܯFٱhӌ]xz"~v}!.q'Zu[j;Pӌv)CN2*%4$Ȓ@H G dP}$#p]!טRJ HSnl]Z56TRwWQ`˳ Pe x:#RYsaSO='j D8Ւi6!**TuU@H A.D-iۨ4Ʌ!L*1ɫ#5#gXt.$&*-4@6 ?5>Z^1ȿ_ SuӰ5Zbڦ ID$Śqk6~޶G23RIJL&]Eݥj@ne I*uktV?KhZRg\֐ivFXڌ= ;V#V9ƒTchjA}Pu6IyIV-9K/8H/mƧIR"nJsiv4؀mHisv3{$ ^*\<5uF]Hۉ>iVr?V9@\ &2pbl9:k5jACNʬ#~6>;cfB j=#Z鴣jH]e1:!vpBPWY "T[VHqW,|B}?' pA/Ǖ-W2dD '5@YOb(Ci7:)q U[ѨiZzݿE#3aX흿M\=CKWv2Tz+:utb$tdpS`qTz [^@G_ v;>*ݥ>۫(v}3,IvNHNH亗5٢H a$JKJzݚZS`ܩG҄^f0*؆J s D:=;FcX \_zk:]ǮL\̣M3bS[6 K"fKS(["l+ݿkv.vP|J~J:1WzAGڣ[Ҍ1|)'\:itm>44ڵ5x=&gi˵kjkH{MS5RY]:ytÜ+ϩ sB0e#X7ZΟ1`^uRN(5 ]({HSlhIsa0aZ/I.}GSzTRs蛮Nڞ۴.!*ȑ *pJ*2s6AhrQnJ!%RJ:ֈ1(ujqv1I;TF:*TQ@N7hh\'*2iRJ5%gt7l#!1ȜnnFҬWzTR\2OIڐSԩRQ_DN s6 4'n*TUmF2LudNA6iLZ8U)˩ Z 2 Y*35CНJ+[:M4sxHHz˚CD*}S9!j} IL? :YӺ)m5:!rqA㨽tu]1ע@mG7ba֫70cM(K#FXt kMHxYgC,q47Tau*YڡbCU(MV#НV_m><]4җ>jB!L+Wi 8jB]8Snڮ&&ɫ,J bG#Ԣzwg힎cKGSpL}{\Yzq'9L=ΜVr8oH\މUs**cJU6:P*=/G[L߼|D ͩΗj/ dfo5w! w HrTA!*Z?c27BקjhKOS#^GHhTni@t!8# ʡ?gzq'TGOVb%WoM;iGZ?JڞM+ik Lk^l #uv+Rm@7ޑŨNbWS4jELgƹW!(s}E]vَk//(.>ɫ(vj'aI@*F"mV0v}5bݱS=)J$T~Їt5e/Yf`@Wj+/NbW1n ?MKǵcf=`]~':T)ţ5ۋFj;v\Cݮ|BϥxDDxH_ZwDGtry迩Jy迩@: Q!tqjo<טRJ6Bi3$t%u*TTUjQHuvzgjhpAVtYbǭHjRJCRk 6uĻGK4H#tske f3J7J*Ys t@*02pڸLE*TR(ےe=ҹ ')UfN*TJل'ViAK\'F*Tc_!4SR9X)RJ"r6RTR0- hd7Lj.*T+6)lИtRPSV{@M<0@pLUSmM9^Ә4ѤJBb`ԙVLƥA) k\@W!j Υ0@LwOWhBRڑt֨jtjR;d4x%*Ӧ!bkj$fEZS󩶠p} HH]jYӒ+W؜BhSA-T`tS]LQyD2+Fha잕Ԉ'#$5ލo$uӉXm@8&K 2*]uZk # h$ց ˧&W!J5hxC#[f3E)3x}JN5'["DvhvGvb`m1_ZNy`^$:Gnnx5k}jNUԝBsu'FMrDZkf-S"5 9y:Rt}!} p]ߊEBz=N_L:K@%FxIT}{|ڵ/z32!Q%tvaڜg®+Є V=-^RՇN@$/$ M(•*U%,v!s22j;Q@H@J*T{NhXɭ٠Ѥm&KjTRH;!sFG$y&I)p!6FTRFj;4' Hcy{n4v׍m֟j4R\LIFEIZANsg cjmRN834R,JqOJ*Tzf鐐IISTR.T*TP.46*Ti)ʍtBh5(iSSu N iq5` MN( "MN .dD{e)- = i:G4S !0tX$EHN]jRfu6#0".4 N J/TQaK͎D^fS 9MU-V(*TgS-+ʔ[P3U车A:;/;/o2KZZg‹^݄mU 0и j*oI^M.enx)S;>$ c ]45S|%@'Wô}5;FEX*n]BJMb2p*<g4e4㫢~1L3({fn3R  j65Gjt [1GzLUajͧh]=RY Vqw7YvԻE;NjQ -HLˆң=ߖu#ȘƗ*=#aiRjnAIRJ!SPO֫5[^n2Q \VD*ʊS_y\qtF!6 'iDTwzťZb FR}`^5fBXW5՚^׺^pm]ExY13Iu%ZcLHnјK;|)LHnјK;|*R4 endstream endobj 1193 0 obj <>stream Adobed     '$''''$25552;;;;;;;;;;   ####''',,,   ####''',,,   ####''',,,W8""   !1AQ"aq2B#3Rr $%&'()*456789:CDEFGHIJSTUVWXYZbcdefghijstuvwxyz!1AQa"q2B#R $%&'()*3456789:CDEFGHIJSTUVWXYZbcdefghijrstuvwxyz?4Xs&:1 l9geIhb&HQ { s(»\H#LY·D. VL[C "Ktr)!u:D桄WVVv[h+=B(kݡ1SV!OR{3Zi{(G"]ú!X~QC^e:"0ɠZMv6 7} 8 gMa6-FrAeWc̙a*h骧 ̫;K" ;i:cwB1iz fӣMLݼʲSM#$lGr[MaPm]2y};}"Rg>][r %$RM 8vBApC6{).5ZɛtDz9\iM\/B%w2zM eIqQ)v; vLsrh軃wF8.&Y-q~p= tOD76FFQk)fUR . FpOp铭r{][&DžxJPYL@ 61pm7Xû#7v I. bZ[*@ctˇJ7!R:qn#"w(j2Lr.]4)B11C V*c 9uMOR$@omVwJ[vXYNuM`)qØ04.mL@9HŠdAI9pS/!4BR3Q>E%5I$Nrxp7ܜGھ쀲ש1tMc!$WWDtU@6ć>rQLN\;oFQ㮶U~!hXuP `nz{U3v7T>juVϸ~cRCG Z;S&Dolմ5g+Vګ bi{nsY]CvE ǙZZ <42R3e: [xGot'pBlFwplv.mtopvތ衺6M:ayΎ!=vk;B-4dОٖRl5cl&FϲuRM/yuIZ}{nor;Fٍ0M: $t)ᰣI$58༜$I//$.^.I$I$0'UT@07(C+% 5iB$J%1&hHD#zFbc5 8q#&I2ahoyOe69HLpdSS1lĘ։t)nC+R,qpkhQm ~ ,!ΐ (# | #5{ØhY ]_D F 0S̀eN`ꖥ'R$ 3p$Z"-1ҖUl6D:Xs8g;2(vǓTk{c"7dٲ0%8V@ L媧RNh즐tpd,q!%Eausp U Ae"vī8IV֜DT$YʼnLnB Sl΋w TEPO2K$%@, 'C&6DԓN{xٓu<ޡ|1P*@%<{(FI@ {PБPh5D&MQ$I][Ev`)ԓ(>ڍؚwA*w aG$];6tC iޠwCmb!;{#{iE6Bn -bn4xlAX 0T4Jł "{EΉIϫA (Wl6Ts$(uW5pyWfvͲ;5(aQ[ecmp=-Ҏ`b:Fgm2Vl;6 EZƩwH9N H  P?n Pn[Љ iBmxgI* ,L'RsP4]46N i&84^kz!m6V/k:lnt~a dl6L‹Z hm.u%ۗK*ZrppubsJ= ZF7p. 8˾g\et;2$!v^NF7TŔY R:\FM` t95)Z5b${NA;&TȢOtŠ.ap9hiqh-zW8Z-^xh܁T@N@R^S/q1ahJi`hks)ԀeӤEJĩ:74M]pdBl8@sW"DCnSz A¿{6pї>;X:Fgx[L{ =1(`N ARI$'1q4I$^ %(CI$) HH kAI$<4筴\[_E)28 6ʵ07%I$k[gCVRKSERE5$M $e^k/dl#5l#44I$@!\% uWIQtlPN+6Ρ~! Eg*`!MaFI#Neq&uI2A2|=F2`o- &8DL$愑X+ >zu6sDҒe^:N(ސ4t%۩dTo)FB7pU%Ro`lXE Q8A\rRmJ8kp(KdĄCg-vS0E3%MtڀHGkZ;|̨8$.2OAa"))T E]BBT.fCѴ>`w:Rb e퓄h7; >4\uTE !;t"saR rH)2[q9DL-d S3)h$&8"om&?kj c*m9GU %+QH9E1c=ec:Kg0@zm }6'P^J%2I&^I (RI$T$/9E$I>SKBkuŴSglnH8dIKmb-Ơ<flW]gQy܀+62$| Q 2{tFyȹ@$uRb*vZI$O}I r)'=8I+za 4I l|. Sd%iM%MWM)$$ %N&i'atNp>yL-B)RH(D'؁2 l.$=&edF=FndF' xzlqq;). WSZ,z!a2I$tD A9@ثNM"W6@8zQ>I{%$x!aлrqfٮE=,63)Hi!L -g(Qmu -ٻfÄmTGCALN .TeHVf^*jqCU7RZ :tb2R=¬[eDaY3X* &o%aǀNQ^df!;=G#} KTmUSa Cdc0phFlRٍV&rE<$E#z#";1יn.5%D^a"˅d8GUA ARXv@ #B\M*0-f Cix0F>A*О]c`ZV:ufbev8!Fww4,m\nx铢a#Msu I4(NPKvJeu`{$l4;w]X,$Rah}tX7$kvgB A:TtC[I76E<rkC@I<˫jp M*U\nMAL7i2FjlD)'ai8 R̈́4c΋m6=pи$u.m̤cLh1d"VE4Y&MsLJZqnQmy$$K A)I鄌ܼ $I$r)KIFb\}N.%#JIlvs+=6zJ( JgF@bSAES=n~~:w5Du f c/emÎѭm^pm@-CFCSȖcH0F+ι*jbI$hc[Ņd&{8H-2LFM҉NR2`2\ !2)pN$K#TJ0 U*kCzK|; s(Q!I:Iwq(2cStKjisr+$,yEcbN%]u¦DUfkθ*ܹ(I" D!J[=*8aet6ŏ. fo7OBe7HiŧU#bU @*dIމ=._5' 8EqR@MTNmjb5mKj801ʞjxS8c ̺m$0:Lu%Pvb.5(ZZ(wnlU՘@.\MNZ 孳 -TqEײ.ɴ1h^18/tE}\{&#D݀9nP:")zʕd@B[#T<r`8-9!FTgNu@"UgJ7=L:aS48VQp6XY ]/*' gd-xf2Nx9nL05!,*UDrw\3xPL@lEӤZIOINi0FHhLc78uIIIh!jW.,51R+RV^lND N ms,5ؘN [ ;-bU.EqŽGB 1κ\!dJ!CGnqYqbExNTcy wO1P;F 9±< TkRm ;SWL#+23xUsb7IQʀ<Č idӳ l3!4)vN APq@DLS.4pbEc>T8]2&ZҦk\,:Kc8{8qB %-'rNHp&kA0jA}G2\S֨[D؜IB";@QEweFƼK6RC&C9]AT[y gl -tvh˴SCŜttꧦ "]N-UjGӑVMڜ)U T`"c۶ܿZM^ch'X"\)G3Fçnt;۳sͳn@3pg 56os ;*nDv6)E.HahCg i- mgf[KW%k=J+6̷ /mCd9'h&a3ziT$a9{A(e,eQah<=TX}:b Eժ;-&BQ~_!٨!dqBOW43tt/de Ov1QRAATj kF*O$)9JHܓxMHD I) %ɴLP]es.9 MJvT6iL)Y.)$u%mdl/VjmFI͂k cvFT$ t1׋InLDN;5#[ 76[FNʜ`@U-IJ:w p1;ړ)f2HIu 7ā`d :S L4@vl6^qKZ eSb6ى!chw+=Ğ~9I'WlD.&E($]6ny'Y휁*1ĶmZ|s0ؕGp'}0O4c;;|ʤ{{%>=K4hK@&OFGrf_ؚd@J#Kr$$GҢ0loBъRoQ=3*ݡ/BCMݞѭ3AT`ųsG\nWö}i hN`7J=BF.;g]܈vg 1kAVmtvkGb:6; ݓy['1~|{=Dsx);Udۛ E@3Mpހt/iu k\4 X^0Ԃ5:V7DL"Βqwp~ș`tu3DxyT+3 n. vSU.d 9&h ;]l`Nka'EoQLU5ͧd47RaϽBt gHUzD:**2T=L:SX.ͽ/2{Quv o.M;%1nm]U&I$eQ2tHR#.=u%rT4q3rsHE>cL O_ILT6 -#Nr w!V2I$af`4-9z9zI$I Ҵ;x@HHpTT%hI$p uD) +I'uu∇3oM\ma 8A I$Hك $ 9rN`zWJ5 2*TQ &$HV!ŽҸ8&h\n2a$7rfުTmu<%\^&YEęɳ9018N:% zͱHRAW%X'sᤜ T: Wù ؃jwf*R\1A\˄10H%nui06ۆATaf Vv1¢'q@qPXڃkiy9.$dn7ǡNq Ρ!;]qqp~kNq!H1A[[ I▉]kt;-& 3Mlܮl /4A HѪW3ɧ VANh"2!7QSpdH7*^svpI/̦BQDJ0iXA+Q@m'bIYk*IJuNا4b[ u.VdS04*K2/ݱO1^hz;d|vm(7Aԃ=W6kC\0'v9%hkf$4g&tkZó.Ŵ"I܇bHڶ] >ڻmhyY(XNā0.th)j.*e1F i w a 'F{ yFѹJ(TPݫkVp2@"9s^6)y^2jgC1`OcvsNzdؘ= pC&"ɂ΢%Rˉ7Bl4>q7$DF mu+öă|;v19y(RQ-Z6Ja={5`I3Yl[;WlC[x~&0RtgFbI7 /""&oDw}\Sg0֍FC:%0O=%pVٟ; @Cw1;>m:WTd^q-qŐ Aj(6mt?f6j,z.;'eQ:St[$)+-ߚD\L[ÁLcK\<.HËSfˡ-kZ'frE'Uතiapߙz=OٍM\8DTnPUo)prN#jRi mQ9܆wlE^BvQ ƙ/\Xވ6q\n^{iVtFݛ08uQ7DB.b+DW "9! ܛ-HHMԘAha0[擏YLv!L[Lk'{!0TM$\*\4^̾͞Df2Cqo[B{,7fF%W I:h4,eE0 Ӻw%sO"q#>;QpiðF:L˙"}F`egd iTz/և0zGnԹ^ ,qN{~ol8b Wl ӡ;Y~I=z ?sGUZP8u mThAtVZD<+y$[NKn }i{@D,m$Qjw ;v8R莆l?h"VaqUk莪R޳ayW&ѳ [oVJev|8VpNVɎTd9FKtNݟE;t@ uBt{x(ۻh8-u÷)\/g%{an*KOra!tU/nע6~d+aUlp;Ik1ye^qiCiӪN0W:2To*B9pf-afg1:*;yQݏmKe3V2[~ù9K[JK^uBcˌ JI$pq7I|\LnOmSfJRI:e)r^2NI^/p6P$I׍HiH+ё&\] QOd:uÙVSlz9^+k|̉TΒ3Us,O2p~?D'FVCa!+UeT:8+w PG"XZ`Z.q2.5U /J g*Ji263l;S`:fM9 2YӲOc[x3L5:vBHccV䃡ݴGNE*LZS{ CL,nQbC!D GnNg6~Ӆ7"oBѻ2IsvUvo#LPWv{v: mm}|oVP٩b%ڜQ=7$(KZCkuζ<0oۊئtP~iEڀp@Z/'NNEՐ 4lTjr aa6pkped%%yRz͂kzt$I$#3PSK0듼BpHLs9y e޼f72I@,7UpnE]kV޷CXeI$*Ō7+W˃4 7$e"(߰fAK譮I?dAktVmM=4uU[Kp8f5S޺*=azqbPc<(x$s;ns$HCtsv55ٸ[gt/BM;1 ފC&6H8[S5 Pm{k#&gilp΂⍫y]/;=4gtpC-dH ɻ=x)mҁkw{76lu6\jSUYMRQjҘitN'6M {l? 2$u%^t+68;-fkS3#i-0|wOO'gяvB'Z w5 3vkOgwot#3Yڨ6}7L(8'yS0e1? yV]kWz#1m7;:#e@tFlA.+Ok*mϺx75c*hs`}2⋤{6uikh\jWlzݷ6D6dꩺ/ͻ'at/GLIk Ӣ6nͤ+Bn NJ|ڵ2T->'2HZK0:ai(oYkjgg.k. :mEl6hLQ%N7\Z q 3 BaØy4 Epp`3@nSF.k7"A`:0T7qzRgp(ьj6H(7 e%By5Z3Q;ifS4/&9JX@ql<;(_ѭ"^uM6 #hzGmb^3;, hzZmHͣ+Dm: JQ\RSYWsWWsTRES58 )َj"՝D8Kk&iJPӲBlon'I$&b`I.]rr K/nH(p&R$Id.WӧN\3ܺ\8pm$teɲSm $I$Y@*S$%G+39X w kI$Fm\c7xswHƵ݈;ȤuRI$-uP|ݢ]*͑EN]8'i% O)C[ȹ*,&Ji e:`7[HRO)&I@&#rBjg36W#=*6''H$.b\J"a{(M*rw:,41uhΔtĥƒl^ʭ 62Pb2SI%jk3B\Pۑ/i>8>Ȝr L`NpJ0 c܂RO)\oMP>鼞dK>'D$q ã4QFmJͨNlT!oW.բ8hMvdA%>34*L{EuJ%ѳZ@]}P^ddUZ.Gh.zn;͟hhh3 ߠ6}uڌϬ$˱^ǁC:W=qv@7m fn,8UBv@6/ҥflΓjP$ {PL@e5-m* aJ Ns\Y>nն3TXîhMvz;ʆS؇zOpޒbAwSR{*kT.ё"ɋE!xLT3J}wn(e0T2Cm5@Z2+4I&L@^I0"bOLu0 郚\;Sa)O B<]q7 әnI$#>SiAɢ;㗶g^9FSI&ת2AO*QM6rj=e>uRI$/q(3L]H}/UO`RjI$GɴFZ U. zYYTI%06\]l2[q% zaΖήBI$g óS2L٨[] 7Y RI$.p=MںUΜ'eL] B GO^R9)LKTާ5 lܽ@ovwiGL4BI$$+XKKH)SRnDlI%c7{$%-%dI$I6DD'1\JIBRI$`Q'E#6fdb.MHC;98I)6$He}4D3U휖jڲP3$)I$]A HoUrj못΁$I4guLs&?$I$Cb4))gRm'b2) ZI2JPx'X =Fyꡩt}(QE2NS)Rd"ƅ"yxydN%2H endstream endobj 1194 0 obj <>stream Adobed     '$''''$25552;;;;;;;;;;   ####''',,,   ####''',,,   ####''',,,W8""  !1AQa"qB2 #$%&'()*3456789:CDEFGHIJRSTUVWXYZbcdefghijrstuvwxyz!1AQ"aq2BR#br $%&'()*3456789:CDEFGHIJSTUVWXYZcdefghijstuvwxyz?rCr+D jM Wl*WRxxӷ 4UjbZʙ=uu0MT].j훞o]uOs*]8ӹJ^vjd&,iX[Rjb=F@Zb?CCZ;AYKo, $أʍ_nGYviE%C8d>JU&ޅD4E(0jɚ,k2oZtsvB{jWi~!^~(2DL&l\0sSY姑 9/?iۦ_Bnƻ6/Gc\<۽q}<$Msi'g ڷ-RH!#,[5'/.2;@ֆ:SToZ0u)XHQH5<)GўFGօ'H1EqAl5<l(ls4J8R$QzUثM 7p'7g\G"sksJ1hK֏оO VnhՍ|Ht*_SC˳3i|X՟KE +~8=(;)=gj Kn޼XK\WFm hyfl!{qZ6o-$oY?bLy7-SК{^g )Q pU=lL)bS  ' Tw5rYaUsBQH)%0$@\ݺ'8y\ Lv4IԢb/[B*ZAnBg=TzF6 NnIPOi550P~A@[<((["|^\~Y;A}m\mn—&䖓m H I YbCrSJKzn@9GULa%\BHR J3H}yI 5*=q#nHRz-"yl;z4Z0\y{GԨ8GCzrw,j:=Jmص1]Za~Fn]L JRpTA@=H';z'r^HvsO9md,7`sGa=(q=7tG3,U+e) amRm>kڨ,f,PDD=z`NZ\QXn NY|`&q6ǰDs!W5U>njċ:A?^*Ҵ, ?K.('ix5C2) &.R)i@IHSųI;`P'.J^Xcj\ox4PP#DS^mj 5'֩V@*pc{=<\@H;z4Q#*8dbSl3^%-Dy:QtS L>I=γSx$!W/W VaֻEٳts/Pt$/HPMd*~GuV9E$k #5Da'(TP[&:PPe "Gks**ea; K@g[;“uI(j"KDF= FϢvaq€2@×v=NCr*O=T ڋ0)512;$rMM6x'Pc&czmfWm9vs jR#i^&XT@Qfma}94I͵tdAH{ij+ }LRggiMO[曢YSdR5-<zu' Q%*c% jQhH)1bL]{WRWTr/\.!<`4fJ`ޛbZ,A [lPц)%0YhV~꫖UT@aS[-i!RIҤE#U`8m(aUIV1d y Z("[4jiDSZ`!sj^Z\wIHp/=,s.I:yc$ U/Rۂ*,(A,OZN!#rҔD*_K$& )Ӥh h rO3*mˊ $)*ԭi b)m#<@ OfBaTor;Àw,qjs_଀v]PlͤM#LBWid 8w f;)0q pX=jߛ#y JqH5k]]]QvE`XC8* d0^,rRRzmC48I}bQpRD6Q-N)F+505n5QC.K Tbݣ)108L.fIצ5m'0A=e[-9ꚳ D D9mK*dMijr@r[ZXHHs^7if\IbX/^Ȯy":$sߠuFq*C*4d4845\,PSRA}03g'" Ecq=أ(22Z.  .8( ^J޻)Rt 5徆]]‹4+[*"NKZ1p3^6ʌCqzl:@$>66r[%DоM)!2Y4JKfv622ssE;8?7}>4|hw! )WiXv>[ *6vKUމ8nߵaJMN?Gt\)C҂ L*P)%eR)qƓBQkFRuPL imX}CSt4&k"q1|:[zΘ ނrPT> vQݶېFJU ƒa= Gs)@W/ :C)SwvT QDeRKDJKR hG;u A3['5&g' )MʈnQ;*¡$PtK =a]qM1I/c^%>؋M A)KkO@ @+HUIO͡  : UqzPA!Iۀ8v"T,i$@< e!i^5\*@E5B!%GH9JNz8n4.|Ih 4\s,"Oe3X%EmS3B6sA3c\":TDfƬmDUq[P5,$B, ^hl@l W Ӛ-^WV;S)4H<{ W!vjͤ[Q"Gf1M=\vDBys쬤*#d4-c4\ֵFQ2&u֎ `9MNur'C]R[n)uFڀqƥl}zUKck+m&vw-nKoM*+6Ԫ*Q&GU^u0:!g]hSkvT%[z@P&A]W$*$~^r+kDdN)E%R@ 'c`5.עb͞Mhe 0 /<aB vah=z5[Yx-,ӰRhj* JyڂWF̥˻n˜)^M|ҫ)Jn'Ac[= 4W209Ƈ<tֆ'vODZj(} I:@Z; DWʔMt|${sU9G*Ue1U( % E <*_ľ(ӈBaDxՙBdmNՔM52359&ZSդUw6 ɩ]W-)Q-©m':THzHJrJN(TaVzu,+ժd9N=ƌM-pM\'"/TX'sW.JU.WoJr MEjA)y7*MzU 08oCtsDfs+9qJ:4>J!{}šn% 'zmX#4nPK);nv4$,$+ϥ1ԃj90Fw@JKҐFOשQp$)K="R'gs>5a>tVXzTZ5!`)*KSjz%qg=SqkyC1pg W 5} QAI3Çi5&AdcJ #AAwAqzF GOY4tbo2w ZMy'9jJ!@dO]RZ!8"=:&pkԵ2H8!CJ-Pz4L EF"@QIӒrxT*Pp }BGE`ꍅ .{/I6ml8pS0`2F'@A0- "2)Y ׯ )=VҔHi/vnYA :[qmDZ>np#UqL7OJZp-t TH~&[ w($TũE9qj 6YlIi'zc&T{C L⠙:dx' IBT8uN MRUje@ #Zw#PTr}$nq ;]|HZʏzH`XJKI* DO,Mcj2"0bSyG4&5?HGwRQzp'Sp38,ߦKVxT A$D>XEHakLInf.`(xuŷ<U9 sΩ*u%dT,v|tbڏWy7$9y!W]7zi_Ri7{EFgRkL.QIU!nFIBA0m䫾w#1Uv FTǨ 3^km;y)Ҹ*9`Kw iDޫ|) ^TJRTŶ1M$q)CSŬ2J¶vNjEg578jEV  iUk寮hվQ0:..jhN :!a!jnK Z.QVsևYu*XcGhW< m&^Y;©uݚ[:W9;Iث6@T1y`.h/jf Wy? r8U4D)(>-x ʉ5xu p+?g%`AWm_)w)G3Pw%\]IsTKۆSBwϪf3ŒE-7R5R^ԹrQh7ڪ޲=Khph.8%Hlu.j&(qRjA*8n^EHSW>#MӦC xx(vR9E*U 5ʓQBH--NUEё9mދ_EZWaxmZ'6H#.*> rqsDu@)1pӔpAOw@PP }΍HPXÂU,˥RYТig= I XIhqsAC IduB`;O~%[՞N *%HlčU%h$qZrS[q [?Y_gh-@('rKKS=DV Hfurs6˜\롷/sjb;I3U^iKu{z-ʭ!eRBHU:[&S5Lr9fnkj~Iy:Hgjv?GyM ձD*|27׵PWԪEG4MzBL`Q̀l taqY%9\*M8%tX;w;rg AL/gYw䂕C8f#WP 븑Ho9*dТvP$px.3ܣ>Ca"$%DDCp)J!YR]N#Ԫr)wmzBdKГ+Ch#RTo+ KK=h⓰$9EeVq3 #v72@#zJ.#R HrqDVwWy6Ru#KfrIu::]K >2*)]fTESш ^Hm""ɸ@Y$!!كI>8פ I;hsܓiBRs\_M!x nr>]joФ :eXjJmYDj8)%3{w((<$1 8q 0h5 $T!V,$)P.#׮u84UTj$< kAYgmv\&)&9( W- &Ir*9P$N֑' [t/S`lKqJ7BCwfaMrIȮ/S2Te{M݁fޚv=ˢ6U]u?Q*CrIcuFk8%k @*U!\N«nhmb{Z2ETR)fR]EC7oRZX5Mq\1]q]W*5FԎJ&Xz[3Ns=ĪV¥k+)iEP#Q30 b,ӕwjh,1B!=HjUuuuu P6ʰm ^PD,]GU<*i/]]]]\^6S5C&d5ZFc-VlL ų ݡ C_gi4\I ãqPݰpwj#/IW֣6.Y|S!DlIg[#(G4v\n ƙ7h[(X'EӃ/J%M A LO!DM J<ӭ M]8]7#ʸL1ӡ 9Mp5aKUC#j@%UtIWLS uG&.בiqܐc>e ԑPiX멭۱izH3F.]Q:2oMȺ`FmҢ4)*$$>8TZ̡T1ʀARj  zR Y)vb*R,ǔuCP*G;Gj.[oS|3qT9/F,:EtS2vfA(t(hlLAH[rVJ &Jl-}Qy2#rkD H;X y4uuuu qF<& 3q렛w$ai5N@:H4\;^VRy&Q+;C'E"FVnbԼCVϓZ90A gҡ< G=jTPgP`)3a뚍S JM7 S;Em]]eEKT$j3w+Zy)& BC2G9*ڷ S&ׂ͓l F#Y 6/%c(p7\Ú/sP40NACuMȮطzQleڌrDҁ'ImM$$84^%pXz/޴|#M^g%8c۵!ӁV+0fQ)m*ߕjʬSIw$V)"%Mvm<a"MmyUXBrXBT_F>ފ.a7 d,'uSLTTsQ)ZI/S^ u[4L4,M0Y@6Dhˊ`A Q\^4;yJxqzIH@N rpM4]]]JBx6]]]I]]^JS1%uuuuuҷ '؝uBu@g^ ͍CpQ -m8%&dnLkIw9Ikp~"Tj+Zذ2 j8uSwJ0fjc"It@TgcMȞmKea"im{yqNFyrmuJ‹pj{5Ԕ5ۛI"{lc~K-V-:H!ӧAڶ{3I{Vnm}hIyaKrPLWRTXUVhhHZш.-j$t$K.jdS,X]XQnM8* VlD99)mAzeخP*=2giofJ"Y9ڴشwHz a$,j}ƣ6Q& ;\5#+(AhNilX.7:";KIk 7OAQb*.풐m$;CuZY**H0?V9J$۶mE6(jUBVRp}z] W&2j@{]H"YmjI="PBӗȫ~jB53 wr)l(:V>ҡǯ[޳u !&XSie2p:$6#4G}J[j.GK @EŨ ?E=T.)ARAJppHF.ݶ @:=mć~Rr80N53TRP+@vSSȄ! O`j5&\LՒ[TK/RHd+M%0ESjE }2)3hEh-J3 U0)7xU."Z,@J[Bޑ =Fآ L7RRuuuuxn^ ZAMj箮Ӳ ҰMc@ԴFLhFh>Tdsf7 T#`x%ϷSC]TԥFs:EtR(lIgٚ̀ԦS$J=iuW5u%uz^h[M@2RnKWWWWW7޹[Zm2vJn۷y:fJ潘U SMu9)*Ijgծ(@*QdJZri.^@JfI~BVl.xEEn(nȯ ▯X Z*ՓUH#jh$l ;E>$)֦0Ɖ ń}dsV=BUa7B fI5MlF}˓mOI&w (N,p ]J%-2SqwEs&S+W8S*n*5MI2R&)E9EYp T5eH6Gs암q4մƭ-;FXK ӨQP ўVi*ŢTWh `r*OF$BJno=ԜpRz=4*`Sy,q vW2o^ m n1 TH3r+}h4XBԠ*SxK+P$5ZM6WzA%G6'ً nD$n p. Å=uăL " MĪĦHK9<JKb5DuӪk 9n9"NQXfLNa+\As'ih9bqdj"ii%H#wTԺj]G26+F5멍\j1{DvltQpl"m+>QkȦ',*U&B/iivR+RFƠAR!8E%#W5/e(룊AvQx:l&INj1|P^6J]h% $\6pjk$#-JIE<iԣOI5*RoZ1ܐ*G8zzGOOrS%5ԈǫVǩP%E1xvP864nt(np9c]6X*nVަ"1 ɂkS7(BeR3¸\b!WCSoYaBFjO>RKu$w#t⒤Bl6בmPj*M)TsSk5O| Т.x4U^+MBr@V>rH(- pwG(ÝX[qpGj|q)%HQ)r,qܚVŨvhW?C(~Sxut{Toq53х"-uXyFXntQsVv/P;AU9Y9$ Nk2n+WU.EWF 垇rkJvYAR#>N܊aBY%Dǎv|,T@ sKQjiYVTqZ$%3Bh|9GF \AL 樃 qA`qޔ0\QyQe7MsT%==gHP(ך 0p2F[b2<=~^A3JJ:n^.dN\ p4Zr@5 ĕ]Mn5JMp~a6LK"]Mg9I恹<kw+i] =ܽQ2ABiHaJ )#'%r*RAw-MslDλ J"R% 1 Iޭ[BuUt.#WQ$9=: 4GL)ݤt:ga!Rܜ$vڊ6hӡ䃹^Iu9LP"n2NrB/U)~̰VX 羫CsIhܗ ͐2n;q! |9 qj)m![j[6MIRli)Tz~j崥: @۽pͩ9%3S+4,(s9*C4%Ej:V^B GEIR&ېz'p]䜥7O(T 4תԪFMsYNR2KɻR= Th ?r~JTWqKPeڮU{ڰVT#/C-KVQz~KcV2F6C:@@'֤媭ڧqRrEZ!C9 ZyBT$UN^r]bZ7=-ԂZoЪu-q7B!]q QCTEy(%rK~UC9J9KpAoR WoSpuYT!9v=VRd;/*q #PpiGB(;X +;oDQar.vvB^5hM>zS\qP'| O`*sj.(Z}UePaꓔx0rEꁈD7tjȉȤRu!R+.()Wt,/CmV uN  N!@;T}PmA`LXcF:p!Il45HxV{.RuHYYa\&QӒ YܪzL\=8{ օ)E8Ց>g9`8{ /Vbsy:D>inSYsFQ.БNi\ӓvpL3=b$qsg>KV`Pw)NDvM16x8I^Wo'i:~cް`xU~]JC>5=hcBZ!;:kFLQ=[pDz/.#$e ||) &PcŪ==U'!h[*.|c]W5ہގWܜê$H(nVM gJS:V69Aw޹Ȃ n03^.Y Hrhn56\)[޻G;骏׍MkS)~ܵFlÍ*4u˻QVйY  xMTM1M3 Մҩ 񣇝 |"&:M"U 6'Q^`K0jH%8by'4$iE%Gj@N jufut=J˜0JNCFiClSvPt$P!hQ\T-x jr+gSr3`Nk, {jh|mqeHj i]˩2SʵRPI?n=,\D*Tqf]]ju 1QG`XHsèRsrxM`ܜ}MVPf΁DBWeХ>:Wޚ[%TG4)J_۶ۺ[o JkV5vb"OmG̫IXj%(|ӨLAހZ^uaZa \(a7 mYґK‰Cyč,wnS͉Ejk)==@SA'tZ[\wJE.iJ γ՟Up -&\QByG6W(LL# )s 2'p) Do}ެzʒT,io}" y{ja IӌJRr43 N~ʏ1J~̹͘N[E5Ʌz\ы%K`lo9i{7fjb`9 X+՛Se渁c=m) p8Q~$. ߢӭ}Onu ,8Bn;oERIODA$+``z P9IHPH$p ҏ'D%zeDftGeM}*M,^ɤ\ԉ[=Dp5(NHhŲMdk$8XH]+Izw/cM$TM=| [cIųLC-K&b҈!1 dKLAOͶ7D.0萻rit\[7uJ!ES&ZGA7)oLq-499Q몖GRJf`_DI5U2ITTmڮ()6S ZXT96[ܻHpܓ^{dؒVsÀbӐ.y:oYۼ 9%X\ћ,c-'wMl$xQ#ʭS4nOkuHL755N"IOBu(4TC>".^HC{XN츠x(UjwBm $)Q $9:: 58 VN*%T qKW4!Ebސt;n8^BFp{j%"\\`A9.殕!]ȩB9y+H @mORp줓psMJWR|jy#9zb搗6JIx4)H&qR!zzvi ERTJz) T9UbX>ŭD/*uX }`K)9Xq*'&ML\85 jBE ;]]Z (oJi*ǾrD9ZYE=uXԮȂ]%rMf9BBn XYɏ&PKc#i#Yî,sЄG;%*QTf Z;(Lsn x 5ԩ,i+W"*ӷ:2\l%DQ:IZO@=.s* ICVHmF^xWOvOcLHh!tͶ giq[J7Vtwгr;ZʣSt('س }>s5woǫ>>uCJoT }:-ҦPUR5Y^ɔ endstream endobj 1195 0 obj <>stream Adobed     '$''''$25552;;;;;;;;;;   ####''',,,   ####''',,,   ####''',,,W""  !A1aQq"#2B $%&'()*3456789:CDEFGHIJRSTUVWXYZbcdefghijrstuvwxyz$g!1A"Qa2Bq #$%&'()*3456789:CDEFGHIJRSTUVWXYZbcdefghijrstuvwxyz?Z2hڇ0p qerlLѦ`+mAhB0 2.ԋ(M&oKluhڵM[.2)'D.,t f*w:JmUM5jȷ>q◯²kNXr֥չ c HdYX$Ҝl%?6' > *Y8bgi^MkqKQFMN3߯G8G H&#֯)S97K{ۑ`C#~Щ:c鄶NaB9VUQ=ԧKs5D+=J|DaҔ=kXTR_K]$2$JM+2Jk|6<4|JRv~%4TqEj5jep2>-.U;lB˱!0R"Zj4JlҔWX$VSCw\f .I TKnARھnA$rSNdtֺIK)r9PXSi٤[Z.z.&"Jp>VDz=<{Xn,4 ^4Y &5+ibډKk<\-FzM :+ BI^nCI[V^TK+#hUֳp9p hZ-gͭ$Uj{MSu0?D:8[tq4uVu7GM׉SϝŭSo0D)- #0魈 'e8ˌS6˱Y: &@UЛq(|LVdؑE]'D$'fF0 6jxm<赺m"[!iGIןXJ T'v}F1lTĪ8.%'\GJem51AրmjNUq4Cڵ'cuUX72Umm૤L,X4$W=4Nc[(ASWҴ[tf[&5 &44[% Ĥ[RdSq!,4eJ,+ttUp%$H5:hef[T4&g0sDؗDטX`*C1 >< Tk{a !M$`RᚂT[lY5ήAi5/"J5p.+ZO)c͞J1ﮌ+MSH/@ȁLKMLu5Lҟ&ZVٱ3д*uOV"4[,L$dGm"~mEIi-饷:dElj31cֽzI8wyyغBO{, n*Z CI& iAҁTʫt*ĩ=Ģv{i^I*iuqppb%BhebE]RƯR1nYcJ׫U2k1AFD 0L%"L{Di5I8D-z錩и@Ą9W\ 6iDI(vd  Eq@2dZ2eC%&88,I$+bHW 4,bfT[ 9GuP`A)ES_R̠MCIˍ ęuRvDvi sfʲ5@KF$cid(C5E57d6:w"d 2W83\N!!5cgY\kk$h^`Jsd[463M-OMijx5+CͿjWXXKI~0͹1i2$U6b.5 2'*q 8)k$Bf?Rf|9(r"Td,iO Jظ '4DSBlQl&G0{PYۮOq&cM K N5SHX+ua5+d)3} CLf.&K_j dȚ Z4"ql~Sl -+a bZUBf;qS4Q)MTt *JT Q^RzB+Rbr b FеeP0\e2̲cz|q*M(eZk[ފ#FH}m$u+{Gb  $ %4cd ۲j)YpU7~ Fk@.0X5!W"mg9s I]A Ff8QMGb6F +Ml4 C0D#NKd` !0rBiMDU%m B"sr1D IDHɷtST2"b e Ar.]! KPH$)"0pʔ:T|b'c9) >3$q7(bN01'P_iHج2148LI $2.C/lȹ-rBģ0 02NZE^/N]Y'Fڴ:-i*eɷ)vp:TzYFtNV\۞[m+1pȝgj)VʙH9QcuS6T:On{&詋x\5e9 I.+dȝ-d-UBl@iPb(L]fDdF AiTJv3NJ!W4[#aɂC^reO`Pr'hV%YYJm2`R%1a &8R2ki R .*hNΒi8JY+B2Lds &'"?-SqîI1Vv,MtBՙFQ I%4s*P_k/%6˦u!k& VD`6$5 ,͹o;53mDd7?%k ք(A37^pɩq6}e< kI,Ɏ|ּ]R^t 6$kR"6QK$ܥ$¦]6yf84ivLKTsĴ*iԢm!jZB~@Aurc ȒҢu1컣fN骥YM&>qjâhU8r6vbNgjqm+9BsDFa`4(>3HuaɢL*^&\.xns4{nG)W:՚ u-+-"( 5*cja.3i&iɸ'4-g( Z-JmT!h'`TuajһWEz)O&]} ZIv$ Pds$T .6|%,Z)l̰e4QdL7;GzF64RAz~JUK<}]oby~V>% 4;Q<b3(htҵa[:ŲY1(Üc 1Sڶ|LZ09%7xmiaS @p %2cjڦ204=zwlG|\q1jVg{.z FҵéНsD2 e'4֫py%]0a'6y2hhXT+W2IDӵcZܢDFPQA TARE.14vԸVSCU^ʶa P5K :áRor:|)+tql)([jm< FڥNImשaԮq7!Ɲ\vv(D0`IU!">,4ҺT󕛎jbbcPĪi7lW*ЫUR3xuf\)"W<Pޒu7NLtp=8_F)US!S08mU!P0:(@IW.T&@YfْMa"vP 3HմeV!iHMuriI˳[ґwaIQ.xȱx{%IP2bfiS1!qOf鐶܇ q NɪEwO^It$ 'FDaz0T0ѥARi#%!2dNU @ӗH\\$qܸfUARsV&!KPqj\w6HRa>jTӶ hyH B[g.d7D)mqb7 JONYߠ&45iiMKX.7VVr[XClIfub7t޳Ϟe m>S2]Rv3!<"bPqRc yqֻJg:Ҙ$&$);$-pg ^ݬoRY.L{mMSDyY8%ek\Z\(f܋jTkW4T9s$ؘq¨b,7~lg^|2U!K\b)#N $XԺs|M-SC.Kfw6twΟ>eaUU)nݤ92Yb&F5Q8mGbx ;MM׉V\+e@hLd^(vՉNKb65fc"d_OCJU`%L\:1ơITA he:{vcQyRiztR:}Cm\Mk-VLz*U=jg^Cm"D0q*U&"Sq%WKYkIbz!Vi3 6GUZXeUBԋ $5DXtqW#pL !8Ĕⱪb|4  2ɂBj5`30 Y9.UIX甸:ݣMatqFvd7 !OLѳb+KK2i:A&EnLsg(X6-S&%US ՘ifdű9dRZTD_=-juØ`McITO-55eSaͲ+c-jm[TV\ JyNzP3V Y $[Ijm%,4YIOGZ,5jѫrV$Z+)N$i(r6lVI*H6(T,N.L"T\NvY{rPmT7b1RRH. $Mk-& Mhv9 EdޥufJVz<ˢ'H5it:ʕJri9W UtӭV+e),:UX Ul^PW8V e4tKMϷfA+VBmfKkɗptq|WMdGNNVmem/&Rx%ik]B7 5q 5T6m[mK5xU [:bifʩUKTDVer+(1iTbVpΘ[]3rD^jd% hT1Uh|5p#9,S9ɳ8$^iQ>,M1\q+I5'` ƲkfT>iVKa(xJxȆP܊ ^v0;3ZM!De\J\*Ǧsd˥B1[&tS&6)M\@GFnޙc\e0M0#jj8Aa4"$] ։7\\Ts,d[U-Է􊪭ތ*UM\6 Ncm\)A& '4Ih-7Off00wM-$iRgY4QUM Ib9{|K&9DYrs|zns{XUi{m %kNQmN%D5cMP61]I84É%41`@m b4Ufd؞z=3E&JG\!(U\PfM] 흀]"TWȆ[(dBOi*2ezpJqrVAKNԕmy" @oMvoo 9ƴSqeK*|5O>e=tԍ*15i&0[Y)C.Ck+EY-ԗ4U-FҜ,MYf23mh0QC]dM$+f[C@J!d%Jqc:ɑBUcfMs\F'3*tqwrȒ^4N9͑(YHg&tg6H:ZjLDe\Jcg7IiFer浫lȯN,BQ[3c19W#pD&%v̤)jskUʎZMʘ#uu̦BZBue82rAAi7lSH0J\T[K5a\pIИTlk@Ȕ%u+6S£Zϟg?cSS{AV=Ĵ ^M)P'%J=ħECԢ˟5]RΗ:.)rRʪS$[]+y2cZCmgY&dC%Xj%f(K}O[u(9#ơvͲMV':ԙWEp,K-B(kM[D #pu6j SUd|FMBV; Ů  B}VDPnh Aeesb fɚH.~T٘FIè@,@إ6d ə5bsLеn@;;N<[RIkȒ)!2fOmR[`ٗP*6m!ԍdYNm5'm1&bL"De5b"x1EF&?;eMr)3=)W;tP4`v SJPSR-j[ *C׶Z97aH P!$، d͐h4EC uں mqҚ.QGheNTS,$apgj7]!&R Ԣkaũ" 2!!1qt]ceRgFӀ׃ 5%X-&#ch2$QMa|Hk^ Z :l1ɩ{ T,mf<붍#:k]BNeβ5Zj15\YסWM9F"dBR,\l"U1ؐL.V9$Urd LdMS28PO̞$0,jP‹LN REJ,DDu&a-l" ,{h+*:6f,ӅcK`٥8m؊jSRnQBTƸSM ͘S2/EkD Ye [ @f& :'$lU kʣ>X@Tolf6H$)8!(ec&u1DޓMŗ3C!prܹ:Mb`l3,IlX(<6N+ƖU#B.tX ƍvCH)aA؅:["[ڰVfK@٤69FUs)f* ]LHL hf2nJPңZ`` mȌ}hUF3єd)hLHHk\493ɞږ8%%ؕ/C]V&-\ E8]FYT[)PB+|[+rnK$j'fk#Us2FEվ0%`rAicf]%q!zD(5LZH@ :SH9D a!M iJBr7&@U-W$$E2\T6fBPd%hibD E i,CCra5E t@NnDFܝ&U4J"-0g"bxGst5Yb c:6g6h(X2," @89ƉCfJ@̓H0R_K tf؁Mhmb /SMuݒiC~ಪٸYv,d\bZ)~bLKP MZ$M]2b̴%XѧjJwS-T 7TX7,K>stream endstream endobj 1208 0 obj <>stream endstream endobj 1207 0 obj <>stream endstream endobj 1206 0 obj <>stream endstream endobj 1205 0 obj <>stream endstream endobj 1189 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\255\220\013\202\001\025\006)-9.9(\026\220\n\013 \220\022\007\016\017\016\001\220\016 \006)-10(\007\025\217\001\020\207 \225\025\002\024 \025\006)-10(\026\002\025\202)10(\025 \221\013\002\013\221\002\025\n)-10(\026\220\026)11(\013 )]TJ 0 -1 TD [(\215\022\221\013\227\220\016\001\026)11.1(\025\r \006\022\025\221\215)21(\207\025\007\016\r\020\024\220 \222\013\f\025\007\016\r\013\001\220\205\024\ \220 \006\220\006)-10(\026)11(\016\024\020 \n\002\025\r\220)]TJ 40.547 1 Td [(Diagnostics and tr)31(eatment of complicated perianal )]TJ 0.208 -1 Td [(abscess in patients with h)11(ematologic malignancies)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0.118 Tw 10 0 0 10 42.5197 188.9979 Tm (\024\006\036\027\022\017 \r)Tj /Span<>> BDC ( )Tj EMC (6)Tj /Span<>> BDC ( )Tj EMC (\(85,7%\) \017)Tj /Span<>> BDC ( )Tj EMC (7 \027\026\002\035\033\007\036\027\017\005. \230\026\022, \023\036\035\034\ \r\017\024)Tj 0 Tw (-)Tj -0.023 Tw 0 -1.218 TD [(\030\036\022\021\026\035\034\027\t\036 )0.6(\026\002\f\006\036\f\f\t )0.5(\002\t\035\017 )0.6(\r\t\016\r\035\036\027\t )0.5(\023\030\017)]TJ /Span<>> BDC ( )Tj EMC 17.441 0 Td (\024\002\f\035\036\007\024\r\026)Tj 0 Tw (-)Tj -0.035 Tw -17.441 -1.218 Td (\027\017\017 \023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\023\024\007\022\024\032\027\t\n\017 \017\027\235\017\035\034\021\030\026\ \021\026\n\017 \r)Tj /Span<>> BDC ( )Tj EMC (2)Tj /Span<>> BDC ( )Tj EMC (\f\035\031)Tj 0 Tw (-)Tj -0.004 Tw T* (\004\026\016\b, \023\026\030\026\030\036\022\021\026\035\034\027\t\n\017\ \f\r\017\013\026\n\017)Tj /Span<>> BDC ( )Tj EMC (\227 \r)Tj /Span<>> BDC ( )Tj EMC (2 \017)Tj /Span<>> BDC ( )Tj EMC (\024\021\f\031\021\f\021\r\017\036\n )Tj 0 Tw T* (\r\027\036\001\027\017\b \023\030\017\027\026\022\024\r \215\222 \r)Tj /Span<>> BDC ( )Tj EMC (2 \f\035\031\004\026\016\b \(\230\026\002\035.)Tj /Span<>> BDC ( )Tj EMC (2\).)Tj 0.321 Tw T* (\200\024\002\031\007\017\021\036\035\017 \017\027\235\036\022\006\017\017\ , \r\t\007\036\035\036\027\027\t\036 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\007\017\026\020\027\024\f)Tj 0 Tw (-)Tj 0.14 Tw T* [(\021\017\022\036 )0.5(\221\205\215 )0.6(\002\t\035\017 )0.5(\023\030\036\007\f\021\026\r\035\036\027\t )0.6(\026\f\f\024\006\017\026\006\017\016\n\017 )0.5(\n\017\022\030\024)]TJ 0 Tw (-)Tj 0.498 Tw T* (\024\030\020\026\027\017\n\024\r, \004\026\013\036 \r\f\021\030\036\004\ \026\035\017\f\034 \001\021\026\n\n\t )Tj /T1_2 1 Tf 0 Tw (Klebsiella )Tj T* (pneumonia )Tj /T1_1 1 Tf 0.538 Tw 5.136 0 Td (\(20%\) \017)Tj /Span<>> BDC ( )Tj EMC /T1_2 1 Tf (Enterococcus faecium )Tj /T1_1 1 Tf 0 Tw (\(20%\), )Tj /T1_2 1 Tf 0.229 Tw -5.136 -1.218 Td [(Pseudomonas aeruginosa )0.5(\(15%\). )]TJ /T1_1 1 Tf (\212\024\035\016 \030\036\017\f\021\036\027\021\027\t\b )Tj 0.06 Tw 23.244 10.96 Td [(\n\017\022\030\024\024\030\020\026\027\017\n\024\r )0.6(\f\024\f\021\026\r\017\035\026 )0.5(25%, )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 15.123 0 Td [(\021\024\n )0.5(\004\017\f\035\036 )0.6(\f)]TJ /Span<>> BDC ( )Tj EMC 5.132 0 Td (\023\030\024)Tj 0 Tw (-)Tj 0.125 Tw -20.255 -1.218 Td (\007\031\022\006\017\036\005 \022\026\030\002\024\023\036\027\036\n\026\ )Tj /Span<>> BDC ( )Tj EMC (\227 5%. \222\027\235\036\022\006\017\017 \022\030\024\r\024\021\024\022\ \026 )Tj -0.042 Tw T* (\023\030\017)Tj /Span<>> BDC ( )Tj EMC 1.712 0 Td [(\221\205\215 )0.5(\r\t\016\r\035\036\027\t )0.5(\031)]TJ /Span<>> BDC ( )Tj EMC (4)Tj /Span<>> BDC ( )Tj EMC 7.514 0 Td [(\(57,1%\) )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC [(7 )0.5(\023\026\006\017\036\027\021\024\r, )0.5(\r\024 \r\f\036\b )]TJ 0.175 Tw -9.226 -1.218 Td (\f\035\031\004\026\016\b \002\t\035\017 \r\t\007\036\035\036\027\t \020\030\ \026\n\024\021\030\017\006\026\021\036\035\034\027\t\036 \n\017\022\030\024\ )Tj 0 Tw (-)Tj T* (\024\030\020\026\027\017\n\t \(\230\026\002\035.)Tj /Span<>> BDC ( )Tj EMC (3\).)Tj 0.113 Tw T* (\200\f\036 \023\026\006\017\036\027\021\t \f\024 \221\205\215 \002\t\035\ \017 \024\023\036\030\017\030\024\r\026\027\t \r)Tj /Span<>> BDC ( )Tj EMC (\f\030\024\004\027\024\n )Tj 0.157 Tw T* [(\023\024\030\016\007\022\036. \207\t\035\024 \r\t\023\024\035\027\036\027\ \024 )0.5(\007\030\036\027\017\030\024\r\026\027\017\036 \026\002\f\006\036\f\f\024\ \r )]TJ 0.219 Tw T* (\023\026\030\026\030\036\022\021\026\035\034\027\t\n \007\024\f\021\031\023\ \024\n, \030\036\r\017\017\016 \026\021\036\022\024\r, \027\036\022\030\ \220)Tj 0 Tw (-)Tj 0.147 Tw T* (\021\024\n\017\016, \026)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\032\036 \021\030\036\n \023\026\006\017\036\027\021\026\n \f\ )Tj /Span<>> BDC ( )Tj EMC (\024\002\001\017\030\027\t\n\017 \023\026\030\026)Tj 0 Tw (-)Tj 0.31 Tw T* (\030\036\022\021\026\035\034\027\t\n\017 \030\026\027\026\n\017 \017)Tj /Span<>> BDC ( )Tj EMC (\f\036\023\f\017\f\024\n \002\t\035\026 \r\t\023\024\035\027\036\027\026\ )Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0.02 Tw 9 0 0 9 42.5197 730.483 Tm (\020\004\206\f\t\204\004 2.)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf ( \206\026\032\026\013\024\031\032\025\t\024\025\013\026 \033\026\203\025\ \031\021\024\n\027 \t\n \t\023\n\204\021\020\003\025 \f\n\032)Tj 0 Tw (-)Tj 0.019 Tw 0 -1.2 TD (\003\026\003\025 \033\026\032\026\033\032\n\013\024\025\024\026 \025)Tj /Span<>> BDC ( )Tj EMC (\030\032\205\202\025\003\025 \f\n\032\003\026\003\025 \033\031\032\025\026\ \021\026\023\022\021\n\017 \025\021)Tj 0 Tw (-)Tj T* (\f\031\013\203\025\025 \(n)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (78\))Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0.079 Tw T* [(T)48(able 2)16(.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf [( Character)-37(istics )0.5(of patients with com)16(plicated )0.5(per)-37(ianal )]TJ 0 Tw T* [(abscess and o)13.1(ther for)-13.9(ms per)-36.9(ianal infection \(n)]TJ /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (78\))Tj ET 0 0 0 1 K 0.5 w /GS2 gs q 1 0 0 1 42.5197 682.781 cm 0 0 m 133.478 0 l S Q q 1 0 0 1 42.7697 670.615 cm 0 0 m 0 11.916 l S Q q 1 0 0 1 175.998 682.781 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 175.998 670.865 cm 0 0 m 0 11.666 l S Q q 1 0 0 1 218.5177 682.781 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 263.872 670.865 cm 0 0 m 0 11.666 l S Q q 1 0 0 1 42.7697 649.099 cm 0 0 m 0 21.516 l S Q q 1 0 0 1 175.748 670.615 cm 0 0 m 42.77 0 l S Q q 1 0 0 1 175.998 649.099 cm 0 0 m 0 21.266 l S Q q 1 0 0 1 218.5177 670.615 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 218.5177 649.099 cm 0 0 m 0 21.266 l S Q q 1 0 0 1 263.872 649.099 cm 0 0 m 0 21.266 l S Q q 1 0 0 1 42.5197 648.849 cm 0 0 m 133.478 0 l S Q q 1 0 0 1 42.7697 636.9409 cm 0 0 m 0 11.658 l S Q q 1 0 0 1 175.998 648.849 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 175.998 636.9409 cm 0 0 m 0 11.658 l S Q q 1 0 0 1 218.5177 648.849 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 218.5177 636.9409 cm 0 0 m 0 11.658 l S Q q 1 0 0 1 263.872 636.9409 cm 0 0 m 0 11.658 l S Q q 1 0 0 1 42.5197 636.6909 cm 0 0 m 133.478 0 l S Q q 1 0 0 1 42.7697 624.7828 cm 0 0 m 0 11.658 l S Q q 1 0 0 1 175.998 636.6909 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 175.998 624.7828 cm 0 0 m 0 11.658 l S Q q 1 0 0 1 218.5177 636.6909 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 218.5177 624.7828 cm 0 0 m 0 11.658 l S Q q 1 0 0 1 263.872 624.7828 cm 0 0 m 0 11.658 l S Q q 1 0 0 1 42.5197 624.5328 cm 0 0 m 133.478 0 l S Q q 1 0 0 1 42.7697 612.6248 cm 0 0 m 0 11.658 l S Q q 1 0 0 1 175.998 624.5328 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 175.998 612.6248 cm 0 0 m 0 11.658 l S Q q 1 0 0 1 218.5177 624.5328 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 218.5177 612.6248 cm 0 0 m 0 11.658 l S Q q 1 0 0 1 263.872 612.6248 cm 0 0 m 0 11.658 l S Q q 1 0 0 1 42.5197 612.3748 cm 0 0 m 133.478 0 l S Q q 1 0 0 1 42.7697 494.8588 cm 0 0 m 0 117.266 l S Q q 1 0 0 1 175.998 612.3748 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 175.998 494.8588 cm 0 0 m 0 117.266 l S Q q 1 0 0 1 218.5177 612.3748 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 218.5177 494.8588 cm 0 0 m 0 117.266 l S Q q 1 0 0 1 263.872 494.8588 cm 0 0 m 0 117.266 l S Q q 1 0 0 1 42.5197 494.6088 cm 0 0 m 133.478 0 l S Q q 1 0 0 1 42.7697 444.2927 cm 0 0 m 0 50.066 l S Q q 1 0 0 1 175.998 494.6088 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 175.998 444.2927 cm 0 0 m 0 50.066 l S Q q 1 0 0 1 218.5177 494.6088 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 218.5177 444.2927 cm 0 0 m 0 50.066 l S Q q 1 0 0 1 263.872 444.2927 cm 0 0 m 0 50.066 l S Q q 1 0 0 1 42.5197 444.0427 cm 0 0 m 133.478 0 l S Q q 1 0 0 1 42.7697 432.1346 cm 0 0 m 0 11.658 l S Q q 1 0 0 1 175.998 444.0427 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 175.998 432.1346 cm 0 0 m 0 11.658 l S Q q 1 0 0 1 218.5177 444.0427 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 218.5177 432.1346 cm 0 0 m 0 11.658 l S Q q 1 0 0 1 263.872 432.1346 cm 0 0 m 0 11.658 l S Q q 1 0 0 1 42.5197 431.8846 cm 0 0 m 133.478 0 l S Q q 1 0 0 1 42.7697 419.9766 cm 0 0 m 0 11.658 l S Q q 1 0 0 1 175.998 431.8846 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 175.998 419.9766 cm 0 0 m 0 11.658 l S Q q 1 0 0 1 218.5177 431.8846 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 218.5177 419.9766 cm 0 0 m 0 11.658 l S Q q 1 0 0 1 263.872 419.9766 cm 0 0 m 0 11.658 l S Q q 1 0 0 1 42.5197 419.7266 cm 0 0 m 133.478 0 l S Q q 1 0 0 1 42.7697 398.2185 cm 0 0 m 0 21.258 l S Q q 1 0 0 1 175.998 419.7266 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 175.998 398.2185 cm 0 0 m 0 21.258 l S Q q 1 0 0 1 218.5177 419.7266 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 218.5177 398.2185 cm 0 0 m 0 21.258 l S Q q 1 0 0 1 263.872 398.2185 cm 0 0 m 0 21.258 l S Q q 1 0 0 1 42.5197 397.9685 cm 0 0 m 133.478 0 l S Q q 1 0 0 1 42.7697 386.0604 cm 0 0 m 0 11.658 l S Q q 1 0 0 1 175.998 397.9685 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 175.998 386.0604 cm 0 0 m 0 11.658 l S Q q 1 0 0 1 218.5177 397.9685 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 218.5177 386.0604 cm 0 0 m 0 11.658 l S Q q 1 0 0 1 263.872 386.0604 cm 0 0 m 0 11.658 l S Q q 1 0 0 1 42.5197 385.8104 cm 0 0 m 133.478 0 l S Q q 1 0 0 1 42.7697 373.9023 cm 0 0 m 0 11.658 l S Q q 1 0 0 1 175.998 385.8104 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 175.998 373.9023 cm 0 0 m 0 11.658 l S Q q 1 0 0 1 218.5177 385.8104 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 218.5177 373.9023 cm 0 0 m 0 11.658 l S Q q 1 0 0 1 263.872 373.9023 cm 0 0 m 0 11.658 l S Q q 1 0 0 1 42.5197 373.6523 cm 0 0 m 133.478 0 l S Q q 1 0 0 1 42.7697 361.7443 cm 0 0 m 0 11.658 l S Q q 1 0 0 1 175.998 373.6523 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 175.998 361.7443 cm 0 0 m 0 11.658 l S Q q 1 0 0 1 218.5177 373.6523 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 218.5177 361.7443 cm 0 0 m 0 11.658 l S Q q 1 0 0 1 263.872 361.7443 cm 0 0 m 0 11.658 l S Q q 1 0 0 1 42.5197 361.4943 cm 0 0 m 133.478 0 l S Q q 1 0 0 1 42.7697 320.7783 cm 0 0 m 0 40.466 l S Q q 1 0 0 1 175.998 361.4943 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 175.998 320.7783 cm 0 0 m 0 40.466 l S Q q 1 0 0 1 218.5177 361.4943 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 218.5177 320.7783 cm 0 0 m 0 40.466 l S Q q 1 0 0 1 263.872 320.7783 cm 0 0 m 0 40.466 l S Q q 1 0 0 1 42.5197 320.5283 cm 0 0 m 133.478 0 l S Q q 1 0 0 1 42.7697 308.6202 cm 0 0 m 0 11.658 l S Q q 1 0 0 1 175.998 320.5283 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 175.998 308.6202 cm 0 0 m 0 11.658 l S Q q 1 0 0 1 218.5177 320.5283 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 218.5177 308.6202 cm 0 0 m 0 11.658 l S Q q 1 0 0 1 263.872 308.6202 cm 0 0 m 0 11.658 l S Q q 1 0 0 1 42.5197 308.3702 cm 0 0 m 133.478 0 l S Q q 1 0 0 1 42.7697 286.8621 cm 0 0 m 0 21.258 l S Q q 1 0 0 1 175.998 308.3702 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 175.998 286.8621 cm 0 0 m 0 21.258 l S Q q 1 0 0 1 218.5177 308.3702 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 218.5177 286.8621 cm 0 0 m 0 21.258 l S Q q 1 0 0 1 263.872 286.8621 cm 0 0 m 0 21.258 l S Q q 1 0 0 1 42.5197 286.6121 cm 0 0 m 133.478 0 l S Q q 1 0 0 1 42.7697 274.704 cm 0 0 m 0 11.658 l S Q q 1 0 0 1 175.998 286.6121 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 175.998 274.704 cm 0 0 m 0 11.658 l S Q q 1 0 0 1 218.5177 286.6121 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 218.5177 274.704 cm 0 0 m 0 11.658 l S Q q 1 0 0 1 263.872 274.704 cm 0 0 m 0 11.658 l S Q q 1 0 0 1 42.5197 274.454 cm 0 0 m 133.478 0 l S Q q 1 0 0 1 42.7697 262.546 cm 0 0 m 0 11.658 l S Q q 1 0 0 1 175.998 274.454 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 175.998 262.546 cm 0 0 m 0 11.658 l S Q q 1 0 0 1 218.5177 274.454 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 218.5177 262.546 cm 0 0 m 0 11.658 l S Q q 1 0 0 1 263.872 262.546 cm 0 0 m 0 11.658 l S Q q 1 0 0 1 42.5197 262.296 cm 0 0 m 133.478 0 l S Q q 1 0 0 1 42.7697 250.3879 cm 0 0 m 0 11.658 l S Q q 1 0 0 1 175.998 262.296 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 175.998 250.3879 cm 0 0 m 0 11.658 l S Q q 1 0 0 1 218.5177 262.296 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 218.5177 250.3879 cm 0 0 m 0 11.658 l S Q q 1 0 0 1 263.872 250.3879 cm 0 0 m 0 11.658 l S Q q 1 0 0 1 42.5197 250.1379 cm 0 0 m 133.478 0 l S Q q 1 0 0 1 175.998 250.1379 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 218.5177 250.1379 cm 0 0 m 45.604 0 l S Q BT /GS1 gs /T1_3 1 Tf 8 0 0 8 89.4401 662.915 Tm (\200\002\220\004\213\004\003\r\f\001)Tj 12.767 1.36 Td (\200\004\204\t\r\b\003\013 n \(%\))Tj -0.214 -2.121 Td (\255\203\200)Tj 4.881 0.6 Td (\031\006\210\n\t\r )Tj -0.779 -1.2 Td (\226\002\006\214\013 \200\034)Tj /T1_1 1 Tf -22.135 -1.476 Td (\223\017\f\035\024 \023\026\006\017\036\027\021\024\r)Tj 18.707 0 Td (7)Tj 5.242 0 Td (71)Tj -23.949 -1.52 Td (\215\024\035 \n/\032)Tj 18.235 0 Td (4/3)Tj 4.992 0 Td (33/41)Tj -23.227 -1.52 Td (\200\024\030\026\f\021 \n\036\007\017\026\027\026 \(\007\017\026\023\026\ \024\027\) \035\036\021)Tj 16.692 0 Td (49)Tj /Span<>> BDC ( )Tj EMC (\(33\22663\))Tj 5.492 0 Td (39)Tj /Span<>> BDC ( )Tj EMC (\(18\22669\))Tj /T1_3 1 Tf -22.184 -1.521 Td (\021\f\t\b\t\201\r\217\220\t\r \212\006\002\235\f\r\b\t\235 \200\034:)Tj /T1_1 1 Tf T* (\222\027\235\017\035\034\021\030\026\021\t)Tj /T1_2 1 Tf T* (\026\032\026\032\031\013\024\026\023\022\021\020\031 \026\005\t\203\031\ \t\t\020)Tj /T1_1 1 Tf T* (\215\024\007\022\024\032\027\t\036)Tj T* (\222\001\017\024\030\036\022\021\026\035\034\027\t\036)Tj T* (\215\036\035\034\r\017\024\030\036\022\021\026\035\034\027\t\036)Tj T* (\221\r\017\013\017 \023\030\016\n\024\005 \022\017\001\022\017)Tj T* (\217\036\022\021\024\r\026\020\017\027\026\035\034\027\t\036 \f\r\017\013\ \017)Tj T* (\215\036\030\235\024\030\026\006\017\017 \023\030\016\n\024\005 \022\017\ \001\022\017 \r\t\001\036 )Tj T* (\031\002\004\026\021\024\005 \035\017\027\017\017)Tj T* (\215\024\030\026\032\036\027\017\016 \023\036\030\017\026\027\026\035\034\ \027\024\005 \022\024\032\017 \(\016\r\t, )Tj T* (\027\036\022\030\024\t\))Tj 18.679 12.001 Td (\226)Tj 0 -2.4 TD (\226)Tj 0 -1.2 TD (\226)Tj -1.208 -1.2 Td (7)Tj /Span<>> BDC ( )Tj EMC (\(100\))Tj 1.208 -1.2 Td (\226)Tj -1.301 -1.2 Td (1)Tj /Span<>> BDC ( )Tj EMC (\(14,3\))Tj 0 -2.4 TD (2)Tj /Span<>> BDC ( )Tj EMC (\(28,6\))Tj 1.301 -2.4 Td (\226)Tj 3.941 12 Td (42)Tj /Span<>> BDC ( )Tj EMC (\(59,1\))Tj T* (13)Tj /Span<>> BDC ( )Tj EMC (\(18,3\))Tj 0.5 -1.2 Td (1)Tj /Span<>> BDC ( )Tj EMC (\(1,4\))Tj /Span<>> BDC ( )Tj EMC 1.051 -1.2 Td (\226)Tj -1.301 -1.2 Td (8)Tj /Span<>> BDC ( )Tj EMC (\(11,3\))Tj /Span<>> BDC ( )Tj EMC 1.301 -1.2 Td (\226)Tj T* (\226)Tj -1.051 -2.4 Td (7)Tj /Span<>> BDC ( )Tj EMC (\(9,9\))Tj /T1_3 1 Tf -23.12 -1.522 Td (\026\004\006\t\004\b\003 \n\r\214\002\206\f\004\217\003\002\213\004:)Tj /T1_1 1 Tf 0 -1.2 TD (\210\f\021\030\t\036 \n\017\036\035\024\017\007\027\t\036 \035\036\005\022\ \024\t)Tj T* (\210\f\021\030\t\005 \035\017\n\235\024\002\035\026\f\021\027\t\005 \035\ \036\005\022\024)Tj T* (\203\036\b\024\007\032\022\017\027\f\022\017\036 \035\017\n\235\024\n\t)Tj T* (\212\030\031\020\017\036*)Tj 17.378 3.601 Td (3)Tj /Span<>> BDC ( )Tj EMC (\(42,8\))Tj T* (2)Tj /Span<>> BDC ( )Tj EMC (\(28,6\))Tj 0 -1.2 TD (2)Tj /Span<>> BDC ( )Tj EMC (\(28,6\))Tj 1.301 -1.2 Td (\226)Tj 3.941 3.6 Td (34)Tj /Span<>> BDC ( )Tj EMC (\(47,9\))Tj 0.25 -1.2 Td (8)Tj /Span<>> BDC ( )Tj EMC (\(11,3\))Tj -0.25 -1.2 Td (17)Tj /Span<>> BDC ( )Tj EMC (\(23,9\))Tj 0 -1.2 TD (12)Tj /Span<>> BDC ( )Tj EMC (\(20,3\))Tj -22.62 -1.521 Td (\217\036\n\017\f\f\017\016 \026\002\024\035\036\r\026\027\017\016 )Tj 17.378 0 Td (3)Tj /Span<>> BDC ( )Tj EMC (\(42,8\))Tj 5.242 0 Td (43)Tj /Span<>> BDC ( )Tj EMC (\(60,5\))Tj -22.62 -1.52 Td (\216\017\n\017\024\021\036\030\026\023\017\016)Tj 17.378 0 Td (4)Tj /Span<>> BDC ( )Tj EMC (\(57,1\))Tj 5.242 0 Td (55)Tj /Span<>> BDC ( )Tj EMC (\(77,5\))Tj -22.62 -1.52 Td (\202\035\035\024-\230\206\221\025)Tj T* (\202\031\021\024-\230\206\221\025)Tj 18.679 1.2 Td (\226)Tj T* (\226)Tj 4.441 1.2 Td (5)Tj /Span<>> BDC ( )Tj EMC (\(7,0\))Tj T* (3)Tj /Span<>> BDC ( )Tj EMC (\(4,2\))Tj -23.12 -1.52 Td (\203\036\005\021\030\024\235\017\035\t)Tj /Span<>> BDC ( )Tj EMC (\252)Tj /Span<>> BDC ( )Tj EMC (500)Tj /Span<>> BDC ( )Tj EMC (\327)Tj /Span<>> BDC ( )Tj EMC (10)Tj 4.664 0 0 4.664 123.0512 392.0059 Tm (9)Tj 8 0 0 8 125.3832 389.3419 Tm ( /\035)Tj 7.498 0 Td (7)Tj /Span<>> BDC ( )Tj EMC (\(100\))Tj 5.15 0 Td (54)Tj /Span<>> BDC ( )Tj EMC (\(76,1\))Tj -22.62 -1.52 Td (\221\024\004\036\021\026\027\017\036 \215\222 \f)Tj /Span<>> BDC ( )Tj EMC (\007\030\031\020\017\n\017 \017\027\235\036\022\006\017\016\n\017)Tj 17.378 0 Td (4)Tj /Span<>> BDC ( )Tj EMC (\(57,1\))Tj 5.242 0 Td (28)Tj /Span<>> BDC ( )Tj EMC (\(39,4\))Tj -22.62 -1.52 Td (\222\027\235\036\022\006\017\017 \022\030\024\r\024\021\024\022\026)Tj 16.878 0 Td (4)Tj /Span<>> BDC ( )Tj EMC (\(57,1\)**)Tj 5.242 0 Td (11)Tj /Span<>> BDC ( )Tj EMC (\(15,5\)**)Tj /T1_3 1 Tf -22.12 -1.521 Td (\035\r\201\r\b\t\r \200\034 \b\004)Tj /Span<>> BDC ( )Tj EMC (\212\006\r\240\013\240\210\227\r\214 \234\003\004\212\r:)Tj /T1_1 1 Tf T* (\202\027\021\017\002\026\022\021\036\030\017\026\035\034\027\026\016 \021\ \036\030\026\023\017\016)Tj T* (\212\030\036\027\017\030\024\r\026\027\017\036 \026\002\f\006\036\f\f\026\ )Tj T* (\203\036 \023\030\024\r\024\007\017\035\024\f\034)Tj 17.378 2.401 Td (4)Tj /Span<>> BDC ( )Tj EMC (\(57,1\))Tj T* (2)Tj /Span<>> BDC ( )Tj EMC (\(28,6\))Tj T* (1)Tj /Span<>> BDC ( )Tj EMC (\(14,3\))Tj 5.242 2.4 Td (19)Tj /Span<>> BDC ( )Tj EMC (\(26,8\))Tj 0.5 -1.2 Td (3)Tj /Span<>> BDC ( )Tj EMC (\(4,2\))Tj -0.5 -1.2 Td (49)Tj /Span<>> BDC ( )Tj EMC (\(69,0\))Tj -22.62 -1.521 Td (\200\t\023\024\035\027\036\027\026 \204\217\230 \024\030\020\026\027\024\ \r \n\026\035\024\020\024 \021\026\026)Tj 17.47 0 Td (7)Tj /Span<>> BDC ( )Tj EMC (\(100\))Tj 5.15 0 Td (17)Tj /Span<>> BDC ( )Tj EMC (\(23,9\))Tj -22.62 -1.52 Td (\212\017\026\020\027\024 \031\f\021\026\027\024\r\035\036\027/\f\022\024\ \030\030\036\022\021\017\030\024\r\026\027 )Tj T* (\023\024\f\035\036 \030\036\031\035\034\021\026\021\024\r \204\217\230)Tj 17.378 0 Td (6)Tj /Span<>> BDC ( )Tj EMC (\(85,7\))Tj 5.742 0 Td (4)Tj /Span<>> BDC ( )Tj EMC (\(5,6\))Tj -23.12 -1.52 Td (\203\026\002\035\033\007\036\027\017\036 \r)Tj /Span<>> BDC ( )Tj EMC (\210\217\222\230)Tj 17.378 0 Td (4)Tj /Span<>> BDC ( )Tj EMC (\(57,1\))Tj 5.742 0 Td (4)Tj /Span<>> BDC ( )Tj EMC (\(5,6\))Tj -23.12 -1.52 Td (\216\017\030\031\030\020\017\004\036\f\022\024\036 \035\036\004\036\027\017\ \036 \215\222)Tj 17.47 0 Td (7)Tj /Span<>> BDC ( )Tj EMC (\(100\))Tj 5.15 0 Td (15)Tj /Span<>> BDC ( )Tj EMC (\(21,1\))Tj -22.62 -1.52 Td (\202\027\021\017\002\026\022\021\036\030\017\026\035\034\027\026\016 \021\ \036\030\026\023\017\016)Tj 17.47 0 Td (7)Tj /Span<>> BDC ( )Tj EMC (\(100\))Tj 5.15 0 Td (56)Tj /Span<>> BDC ( )Tj EMC (\(78,9\))Tj /T1_2 1 Tf 7 0 0 7 42.5197 238.6532 Tm (\032\025\003\031\006\026\021\025\031: * \023\025\003\f\n\003\026 \206\n\ \030\204\013\025\021\026 n)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (5, \003\021\n\204\031\t\024\027\031\021\021\026\002 \003\025\031\023\n\003\ \026 n)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (4, )Tj T* (\004\032\n\021\025\006\031\t\013\025\017 \003\025\031\023\n\025\030\021\020\ \017 \023\031\017\013\n\016 n)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (3, \004\032\n\021\025\006\031\t\013\025\017 \023\025\003\f\n\023\031\017\ \013\n\016 n)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (2; )Tj T* [(**\t\024\026)49(\024\025\t\024\025\006\031\t\013\025 \016\021\026\006\025\003\n\031 \032\ \026\016\023\025\006\025\031 \032)]TJ /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (0,05)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf -0.059 Tw 9 0 0 9 274.9606 730.483 Tm (\020\004\206\f\t\204\004 3.)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf ( \207\033\031\013\024\032 \003\025\013\032\n\n\032\202\026\021\025\016\003\ \n\027, \027\020\030\031\023\031\021\021\020\004 \033\032\025)Tj /Span<>> BDC ( )Tj EMC (\030\025\026\202)Tj 0 Tw (-)Tj 0.188 Tw T* [(\021\n\t\024\025\013\031 )0.5(\t\023\n\204\021\020\004 )0.5(\f\n\032\003 )0.5(\033\026\032\026\033\032\n\013\024\025\024\026 )0.6(\025\016)]TJ /Span<>> BDC ( )Tj EMC 18.517 0 Td [(\033\032\002\003\n\017 )0.5(\013\025\001\013\025 )]TJ 0 Tw -18.517 -1.2 Td (\025)Tj /Span<>> BDC ( )Tj EMC (\025\016 \013\032\n\027\025)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf -0.012 Tw T* [(T)48(able 3.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf [( Div)13(ersity of microorg)12.1(anis)33(ms in blood and in rectum de)]TJ 0 Tw (-)Tj T* [(tected via com)16.1(plicated per)-36.8(ianal abscess diagnostics)]TJ ET /GS2 gs q 1 0 0 1 274.9606 682.781 cm 0 0 m 107.967 0 l S Q q 1 0 0 1 275.2106 671.3118 cm 0 0 m 0 11.219 l S Q q 1 0 0 1 382.9272 682.781 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 382.9272 671.5618 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 439.6201 682.781 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 496.313 671.5618 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 275.2106 640.8926 cm 0 0 m 0 30.419 l S Q q 1 0 0 1 382.6772 671.3118 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 382.9272 640.8926 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 439.6201 671.3118 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 439.6201 640.8926 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 496.313 640.8926 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 274.9606 640.6426 cm 0 0 m 107.967 0 l S Q q 1 0 0 1 275.2106 629.4313 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 382.9272 640.6426 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 382.9272 629.4313 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 439.6201 640.6426 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 439.6201 629.4313 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 629.4313 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 274.9606 629.1813 cm 0 0 m 107.967 0 l S Q q 1 0 0 1 275.2106 617.97 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 382.9272 629.1813 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 382.9272 617.97 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 439.6201 629.1813 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 439.6201 617.97 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 617.97 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 274.9606 617.72 cm 0 0 m 107.967 0 l S Q q 1 0 0 1 275.2106 606.5087 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 382.9272 617.72 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 382.9272 606.5087 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 439.6201 617.72 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 439.6201 606.5087 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 606.5087 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 274.9606 606.2587 cm 0 0 m 107.967 0 l S Q q 1 0 0 1 275.2106 595.0474 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 382.9272 606.2587 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 382.9272 595.0474 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 439.6201 606.2587 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 439.6201 595.0474 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 595.0474 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 274.9606 594.7974 cm 0 0 m 107.967 0 l S Q q 1 0 0 1 275.2106 583.5862 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 382.9272 594.7974 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 382.9272 583.5862 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 439.6201 594.7974 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 439.6201 583.5862 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 583.5862 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 274.9606 583.3362 cm 0 0 m 107.967 0 l S Q q 1 0 0 1 275.2106 572.1249 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 382.9272 583.3362 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 382.9272 572.1249 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 439.6201 583.3362 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 439.6201 572.1249 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 572.1249 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 274.9606 571.8749 cm 0 0 m 107.967 0 l S Q q 1 0 0 1 275.2106 560.6636 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 382.9272 571.8749 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 382.9272 560.6636 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 439.6201 571.8749 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 439.6201 560.6636 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 560.6636 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 274.9606 560.4136 cm 0 0 m 107.967 0 l S Q q 1 0 0 1 275.2106 549.2023 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 382.9272 560.4136 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 382.9272 549.2023 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 439.6201 560.4136 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 439.6201 549.2023 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 549.2023 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 274.9606 548.9523 cm 0 0 m 107.967 0 l S Q q 1 0 0 1 275.2106 537.741 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 382.9272 548.9523 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 382.9272 537.741 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 439.6201 548.9523 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 439.6201 537.741 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 537.741 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 274.9606 537.491 cm 0 0 m 107.967 0 l S Q q 1 0 0 1 275.2106 507.0797 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 382.9272 537.491 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 382.9272 507.0797 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 439.6201 537.491 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 439.6201 507.0797 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 496.313 507.0797 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 274.9606 506.8297 cm 0 0 m 107.967 0 l S Q q 1 0 0 1 275.2106 495.6185 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 382.9272 506.8297 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 382.9272 495.6185 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 439.6201 506.8297 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 439.6201 495.6185 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 495.6185 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 274.9606 495.3685 cm 0 0 m 107.967 0 l S Q q 1 0 0 1 275.2106 484.1572 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 382.9272 495.3685 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 382.9272 484.1572 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 439.6201 495.3685 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 439.6201 484.1572 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 484.1572 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 274.9606 483.9072 cm 0 0 m 107.967 0 l S Q q 1 0 0 1 275.2106 463.0959 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 382.9272 483.9072 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 382.9272 463.0959 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 439.6201 483.9072 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 439.6201 463.0959 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 496.313 463.0959 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 274.9606 462.8459 cm 0 0 m 107.967 0 l S Q q 1 0 0 1 275.2106 451.6346 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 382.9272 462.8459 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 382.9272 451.6346 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 439.6201 462.8459 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 439.6201 451.6346 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 451.6346 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 274.9606 451.3846 cm 0 0 m 107.967 0 l S Q q 1 0 0 1 382.9272 451.3846 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 439.6201 451.3846 cm 0 0 m 56.943 0 l S Q BT /GS1 gs /T1_3 1 Tf 8 0 0 8 298.5213 658.8118 Tm (\215\t\220\006\002\002\006\n\004\b\t\213\214\013)Tj 13.801 1.917 Td (\035\002\220\210\217 \013\240\r\f\r\b\t\235)Tj -2.275 -1.434 Td (\215\t\220\006\002\002\006\n\004)Tj (-)Tj -0.577 -1.2 Td (\b\t\213\214\013 \212\006\235\214\004\235 )Tj 0.302 -1.2 Td (\220\t\230\220\004 )Tj /T1_4 1 Tf (n)Tj /T1_3 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (19)Tj 7.362 2.4 Td (\215\t\220\006\002\002\006\n\004)Tj (-)Tj -0.275 -1.2 Td (\b\t\213\214\013 \220\006\002\001 )Tj /T1_4 1 Tf 1.794 -1.2 Td (n)Tj /T1_3 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (4)Tj /T1_1 1 Tf -22.692 -1.433 Td (\206\030\026\n\024\021\030\017\006\026\021\036\035\034\027\t\036 \002\026\ \022\021\036\030\017\017 )Tj 14.825 0 Td (12)Tj /Span<>> BDC ( )Tj EMC (\(63,2\))Tj 7.429 0 Td (4)Tj /Span<>> BDC ( )Tj EMC (\(100\))Tj -22.254 -1.433 Td (\221\036\n\036\005\f\021\r\024 )Tj /T1_2 1 Tf (Enterobacteriaceae)Tj /T1_1 1 Tf 14.825 0 Td (10)Tj /Span<>> BDC ( )Tj EMC (\(52,6\))Tj 7.679 0 Td (3)Tj /Span<>> BDC ( )Tj EMC (\(75\))Tj /T1_2 1 Tf -22.504 -1.433 Td (Klebsiella spp., \025\016 \021\025\004)Tj /T1_1 1 Tf 15.075 0 Td (4)Tj /Span<>> BDC ( )Tj EMC (\(21,1\))Tj 7.429 0 Td (2)Tj /Span<>> BDC ( )Tj EMC (\(50\))Tj /T1_2 1 Tf -21.441 -1.433 Td (\t \033\032\n\030\205\013\203\025\031\017 \213\035\212\207)Tj /T1_1 1 Tf 14.012 0 Td (2)Tj /Span<>> BDC ( )Tj EMC (\(10,5\))Tj 7.429 0 Td (2)Tj /Span<>> BDC ( )Tj EMC (\(50\))Tj /T1_2 1 Tf -21.441 -1.433 Td (\013\026\032\005\n\033\031\021\003\032\031\016\025\t\024\031\021\024\021\ \020\031)Tj /T1_1 1 Tf 14.262 0 Td (1)Tj /Span<>> BDC ( )Tj EMC (\(5,3\))Tj 8.166 0 Td (0)Tj /T1_2 1 Tf -23.49 -1.433 Td (Proteus spp)Tj /T1_1 1 Tf 15.075 0 Td (3)Tj /Span<>> BDC ( )Tj EMC (\(15,8\))Tj 8.416 0 Td (0)Tj /T1_2 1 Tf -23.49 -1.433 Td (Escherichiacoli, \025\016)Tj /Span<>> BDC ( )Tj EMC (\021\025\004)Tj /T1_1 1 Tf 15.075 0 Td (2)Tj /Span<>> BDC ( )Tj EMC (\(10,5\))Tj 7.429 0 Td (1)Tj /Span<>> BDC ( )Tj EMC (\(25\))Tj /T1_2 1 Tf -21.441 -1.433 Td (\t \033\032\n\030\205\013\203\025\031\017 \213\035\212\207)Tj /T1_1 1 Tf 14.012 0 Td (2)Tj /Span<>> BDC ( )Tj EMC (\(10,5\))Tj 7.429 0 Td (1)Tj /Span<>> BDC ( )Tj EMC (\(25\))Tj /T1_2 1 Tf -22.504 -1.433 Td (Enterobacter spp.)Tj /T1_1 1 Tf 15.325 0 Td (1)Tj /Span<>> BDC ( )Tj EMC (\(5,3\))Tj 8.166 0 Td (0)Tj -23.49 -1.433 Td (\203\036\235\036\030\n\036\027\021\017\030\031\033\013\017\036 \002\026\022\ \021\036\030\017\017)Tj /T1_2 1 Tf T* (Pseudomonas aeruginosa;)Tj T* (Stenotrophomonas maltophilia)Tj /T1_1 1 Tf 15.325 1.2 Td (1)Tj /Span<>> BDC ( )Tj EMC (\(5,3\))Tj T* (1)Tj /Span<>> BDC ( )Tj EMC (\(5,3\))Tj 7.179 1.2 Td (1)Tj /Span<>> BDC ( )Tj EMC (\(25\))Tj 0.986 -1.2 Td (0)Tj -23.49 -1.433 Td (\206\030\026\n\023\024\035\024\032\017\021\036\035\034\027\t\036 \002\026\ \022\021\036\030\017\017 )Tj 15.075 0 Td (4)Tj /Span<>> BDC ( )Tj EMC (\(21,1\))Tj 8.416 0 Td (0)Tj /T1_2 1 Tf -23.49 -1.433 Td (Enterococcus spp;)Tj /T1_1 1 Tf 15.075 0 Td (4)Tj /Span<>> BDC ( )Tj EMC (\(21,1\))Tj 8.416 0 Td (0)Tj /T1_2 1 Tf -23.49 -1.433 Td (Enterococcus faecium)Tj /T1_1 1 Tf ( )Tj T* (\r\026\027\022\024\n\017\006\017\027-\031\f\021\024\005\004\017\r\t\036)Tj 15.325 1.2 Td (1)Tj /Span<>> BDC ( )Tj EMC (\(5,3\))Tj 8.166 0 Td (0)Tj -23.49 -2.633 Td (\206\030\017\002\t )Tj /T1_2 1 Tf (\207andida spp)Tj /T1_1 1 Tf 15.075 0 Td (3)Tj /Span<>> BDC ( )Tj EMC (\(15,8\))Tj 8.416 0 Td (0)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 9 0 0 9 274.9606 434.6653 Tm (\020\004\206\f\t\204\004 4.)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf ( \035\031\006\031\021\025\031 \t\023\n\204\021\020\004 \f\n\032\003 \033\ \026\032\026\033\032\n\013\024\025\024\026)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf T* [(T)48(able 4.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf [( T)56.1(reatment of com)16.1(plicated per)-36.9(ianal abscess)]TJ ET /GS2 gs q 1 0 0 1 274.9606 419.3633 cm 0 0 m 173.163 0 l S Q q 1 0 0 1 275.2106 388.9441 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 448.124 419.3633 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 448.124 388.9441 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 496.313 388.9441 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 274.9606 388.6941 cm 0 0 m 173.163 0 l S Q q 1 0 0 1 275.2106 377.4749 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 448.124 388.6941 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 448.124 377.4749 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 496.313 377.4749 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 274.9606 377.2249 cm 0 0 m 173.163 0 l S Q q 1 0 0 1 275.2106 366.0136 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 448.124 377.2249 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 448.124 366.0136 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 366.0136 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 274.9606 365.7636 cm 0 0 m 173.163 0 l S Q q 1 0 0 1 275.2106 354.5523 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 448.124 365.7636 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 448.124 354.5523 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 354.5523 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 274.9606 354.3023 cm 0 0 m 173.163 0 l S Q q 1 0 0 1 275.2106 343.091 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 448.124 354.3023 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 448.124 343.091 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 343.091 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 274.9606 342.841 cm 0 0 m 173.163 0 l S Q q 1 0 0 1 275.2106 331.6218 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 448.124 342.841 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 448.124 331.6218 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 496.313 331.6218 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 274.9606 331.3718 cm 0 0 m 173.163 0 l S Q q 1 0 0 1 275.2106 320.1605 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 448.124 331.3718 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 448.124 320.1605 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 320.1605 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 274.9606 319.9105 cm 0 0 m 173.163 0 l S Q q 1 0 0 1 275.2106 308.6992 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 448.124 319.9105 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 448.124 308.6992 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 308.6992 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 274.9606 308.4492 cm 0 0 m 173.163 0 l S Q q 1 0 0 1 275.2106 297.2379 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 448.124 308.4492 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 448.124 297.2379 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 297.2379 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 274.9606 296.9879 cm 0 0 m 173.163 0 l S Q q 1 0 0 1 275.2106 285.7767 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 448.124 296.9879 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 448.124 285.7767 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 285.7767 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 274.9606 285.5267 cm 0 0 m 173.163 0 l S Q q 1 0 0 1 275.2106 274.3154 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 448.124 285.5267 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 448.124 274.3154 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 274.3154 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 274.9606 274.0654 cm 0 0 m 173.163 0 l S Q q 1 0 0 1 275.2106 243.6541 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 448.124 274.0654 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 448.124 243.6541 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 496.313 243.6541 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 274.9606 243.4041 cm 0 0 m 173.163 0 l S Q q 1 0 0 1 275.2106 232.1928 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 448.124 243.4041 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 448.124 232.1928 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 232.1928 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 274.9606 231.9428 cm 0 0 m 173.163 0 l S Q q 1 0 0 1 275.2106 220.7315 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 448.124 231.9428 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 448.124 220.7315 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 220.7315 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 274.9606 220.4815 cm 0 0 m 173.163 0 l S Q q 1 0 0 1 448.124 220.4815 cm 0 0 m 48.439 0 l S Q BT /GS1 gs /T1_3 1 Tf 8 0 0 8 341.7236 401.1287 Tm (\200\002\220\004\213\004\003\r\f\001)Tj 14.986 1.2 Td (\030\t\217\f\002 )Tj -0.966 -1.2 Td (\212\004\204\t\r\b\003\002 )Tj /T1_4 1 Tf 0.384 -1.2 Td (n)Tj /T1_3 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (7\(%\))Tj -22.363 -1.434 Td (\255\006\002\201\b\013\r \002\212\r\006\004\204\t\t \212\002)Tj /Span<>> BDC ( )Tj EMC (\212\002\002\240\210 \255\203\200:)Tj /T1_1 1 Tf 0 -1.433 TD (\212\030\036\027\017\030\024\r\026\027\017\036 \023\026\030\026\030\036\022\ \021\026\035\034\027\024\005 \022\035\036\021\004\026\021\022\017)Tj 22.785 0 Td (7)Tj /Span<>> BDC ( )Tj EMC (\(100\))Tj -22.785 -1.433 Td (\205\024\030\n\017\030\024\r\026\027\017\036 \022\024\035\024\f\021\024\n\ \t)Tj 22.693 0 Td (3)Tj /Span<>> BDC ( )Tj EMC (\(42,9\))Tj -22.693 -1.433 Td (\200\026\022\031\031\n-\021\036\030\026\023\017\016)Tj 22.693 0 Td (2)Tj /Span<>> BDC ( )Tj EMC (\(28,6\))Tj /T1_3 1 Tf -22.693 -1.434 Td (\200\f\004\b\002\013\r \002\212\r\006\004\204\t\t:)Tj /T1_1 1 Tf 1.063 -1.433 Td (\003\026\022\030\t\021\017\036 \f\017\020\n\024\f\021\024\n\t)Tj 21.63 0 Td (2)Tj /Span<>> BDC ( )Tj EMC (\(28,6\))Tj -21.63 -1.433 Td (\215\035\026\f\021\017\022\026 \023\030\024\n\036\032\027\024\f\021\017 \ \n\036\f\021\027\t\n\017 \021\022\026\027\016\n\017)Tj 21.63 0 Td (1)Tj /Span<>> BDC ( )Tj EMC (\(14,3\))Tj -21.63 -1.433 Td (\215\035\026\f\021\017\022\026 \030\036\022\021\024\r\026\020\017\027\026\ \035\034\027\024\005 \023\036\030\036\020\024\030\024\007\022\017)Tj 21.63 0 Td (1)Tj /Span<>> BDC ( )Tj EMC (\(14,3\))Tj -21.63 -1.433 Td (\222\f\f\036\004\036\027\017\036 \023\026\030\026\030\036\022\021\026\035\ \034\027\024\020\024 \f\r\017\013\026)Tj 21.63 0 Td (1)Tj /Span<>> BDC ( )Tj EMC (\(14,3\))Tj -22.693 -1.433 Td (\221\030\036\007\027\017\005 \f\030\024\022 \030\036\023\026\030\026\006\ \017\017 \030\026\027 \(\007\017\026\023\026\024\027\) \007\027\017)Tj 21.757 0 Td (79)Tj /Span<>> BDC ( )Tj EMC (\(37\226142\))Tj -21.757 -1.433 Td (\215\030\024\r\036\007\036\027\017\036 \023\030\024\020\030\026\n\n\t \216\ \230 \023\024\f\035\036 \220\023\017\024\007\026 \215\222)Tj 0 -1.2 TD (\230\030\026\027\f\023\035\026\027\021\026\006\017\016 \026\035\035\024\020\ \036\027\027\t\b \020\036\n\024\023\024\220\021\017\004\036\f\022\017\b \ )Tj T* (\f\021\r\024\035\024\r\t\b \022\035\036\021\024\022 \022\030\024\r\017)Tj 22.693 2.4 Td (4)Tj /Span<>> BDC ( )Tj EMC (\(57,1\))Tj T* (1)Tj /Span<>> BDC ( )Tj EMC (\(14,3\))Tj -0.01 Tc 7.68 0 0 8 278.0453 234.7774 Tm (\212\024\f\021\017\020\027\031\021\026 \030\036\n\017\f\f\017\016 \020\036\ \n\024\002\035\026\f\021\024\026 \023\024\f\035\036 \220\023\017\024\007\ \026 \215\222)Tj 0 Tc 8 0 0 8 459.5866 234.7774 Tm (3)Tj /Span<>> BDC ( )Tj EMC (\(42,9\))Tj -22.693 -1.433 Td (\211\n\036\030\035\024)Tj 22.693 0 Td (2)Tj /Span<>> BDC ( )Tj EMC (\(28,6\))Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\033\030\031\030\213\b)-20.9(\035\231\213\233\t \021\032)50(\b)42(\032\231\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj /T1_5 1 Tf 25 0 0 25 504.6522 56.0378 Tm (121)Tj ET endstream endobj 1179 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1180 0 obj <>/ExtGState<>/Font<>/ProcSet[/PDF/Text]/Properties<>/Shading<>/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1181 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1182 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1183 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1217 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.167 Tw 10 0 0 10 70.8661 724.8299 Tm (7)Tj /Span<>> BDC ( )Tj EMC (\026\021\n\024\f\235\036\030. \200\026\022\031\031\n-\017\027\f\021\017\035\ \035\016\006\017\024\027\027\026\016 \021\036\030\026\023\017\016 \023\030\ \017)Tj 0 Tw (-)Tj -0.022 Tw 0 -1.218 TD [(\n\036\027\016\035\026\f\034 )0.6(\031)]TJ /Span<>> BDC ( )Tj EMC 4.702 0 Td [(\f\021\024\n\017\030\024\r\026\027\027\t\b )0.6(\023\026\006\017\036\027\021\024\r. )0.5(\215\030\017)]TJ /Span<>> BDC ( )Tj EMC 13.297 0 Td (\235\024\030\n\017\030\024)Tj 0 Tw (-)Tj -0.03 Tw -17.999 -1.218 Td (\r\026\027\017\017 \r\026\022\031\031\n\027\024\005 \023\024\r\016\022\017\ \027\026)Tj /Span<>> BDC ( )Tj EMC (\007\027\024 \030\026\027\t \031\f\021\026\027\026\r\035\017\r\026\035\017\ )Tj 0.321 Tw T* (\007\030\036\027\026\032 \007\035\016 \017\027\f\021\017\035\035\016\006\ \017\017 \030\026\f\021\r\024\030\024\r \026\027\021\017\f\036\023\021\017\ \022\024\r, )Tj 0.036 Tw T* (\023\024\f\035\036 \004\036\020\024 \030\026\027\036\r\024\036 \035\024\032\ \036 \026\023\024\035\027\016\035\017 \023\024\035\017\031\030\036\021\026\ \027\024\r\024\005 )Tj 0.066 Tw T* (\020\031\002\022\024\005. \212\035\016 \020\036\030\n\036\021\017\026\006\ \017\017 \017\f\023\024\035\034\024\r\026\035\017 \023\035\036\027\022\031\ , \023\024\007 )Tj 0.196 Tw 0 -1.218 TD (\022\024\021\024\030\031\033 \023\024\020\030\031\032\026\035\f\016 \007\ \030\036\027\026\032\027\t\005 \023\024\030\021. \200)Tj /Span<>> BDC ( )Tj EMC (\235\026\036 \r\024\f)Tj 0 Tw (-)Tj 0.08 Tw 0 -1.218 TD [(\023\026\035\036\027\017\016 )0.5(\017\f\023\024\035\034\024\r\026\035\017 )0.5(\030\026\030\036\032\036\027\017\036)]TJ /Span<>> BDC ( )Tj EMC 15.055 0 Td [(\227 120 \n\n )0.5(\030\021.\f\021., )]TJ 0.11 Tw -15.055 -1.218 Td (\r)Tj /Span<>> BDC ( )Tj EMC [(\023\036\030\017\024\007 )0.5(\030\036\023\026\030\026\006\017\017 \007\035\016 )0.5(\f\021\017\n\031\035\016\006\017\017 )0.5(\030\024\f\021\026 \020\030\026\027\031\035\016)]TJ 0 Tw (-)Tj 0.096 Tw T* (\006\017\005)Tj /Span<>> BDC ( )Tj EMC (\227 \023\036\030\036\n\036\027\027\024\036 \030\026\030\036\032\036\027\ \017\036)Tj /Span<>> BDC ( )Tj EMC (\227 50\22680)Tj /Span<>> BDC ( )Tj EMC (\n\n \030\021.)Tj /Span<>> BDC ( )Tj EMC (\f\021. )Tj 0.343 Tw T* (\003\026\n\036\027\031 \022\024\n\023\024\027\036\027\021\024\r \f\017\f\ \021\036\n\t \024\f\031\013\036\f\021\r\035\016\035\017 \004\036\030\036\  )Tj 0 Tw T* (48)Tj /Span<>> BDC ( )Tj EMC (\004\026\f\024\r.)Tj /T1_1 1 Tf 0.306 Tw 0 -1.218 TD (\255\003\004\003\t\217\003\t\201\r\217\220\t\005 \004\b\004\f\t\213)Tj /T1_0 1 Tf ( \023\030\024\r\024\007\017\035\f\016 \027\026)Tj /Span<>> BDC ( )Tj EMC (\n\026\021\036\030\017\026\035\036 )Tj 0.121 Tw 0 -1.218 TD [(\002\026\t )0.5(\007\026\027\027\t\b, )0.6(\f\024\007\026\027\027\024\005 )0.5(\007\035\016 )0.6(\007\026\027\027\024\020\024 )0.5(\017\f\f\035\036\007\024\r\026\027\017\016, )]TJ 0.088 Tw 0 -1.218 TD (\017)Tj /Span<>> BDC ( )Tj EMC (\r\022\035\033\004\026\035 \f\021\026\027\007\026\030\021\027\t\036 \n\036\ \021\024\007\t \024\023\017\f\026\021\036\035\034\027\024\005 \f\021\026\ \021\017)Tj 0 Tw (-)Tj 0.083 Tw T* (\f\021\017\022\017. \212\035\016 \023\030\024\r\036\030\022\017 \020\017\ \023\024\021\036 \024)Tj /Span<>> BDC ( )Tj EMC (\030\026\035\017\004\017\016\b \030\026\f\023\030\036\007\036)Tj 0 Tw (-)Tj 0.117 Tw T* (\035\036\027\017\005 \022\026\021\036\020\024\030\017\026\035\034\027\t\b\ \023\030\017\027\026\022\024\r \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\026\b \f\030\026\r\027\036)Tj 0 Tw (-)Tj 0.29 Tw T* (\027\017\016 \017\f\023\024\035\034\024\r\026\035\f\016 \026\027\026\035\ \017 \021\026\002\035\017\006 \f\024\023\030\016\032\036\027\027\024\f\021\ \017. )Tj T* [(\212\035\016 \024\006\036\027\022\017 \027\026\004\017\n\024\f\021\017 \ \023\030\017\n\036\027\016\035\f\016 )0.5(\007\r\031\f\021\024\030\024\027\027\017\005 )]TJ -0.009 Tw T* (\022\030\017\021\036\030\017\005 \205\017\001\036\030\026 \(\007\035\016\ \021\026\002\035\017\006 2*2\) \017)Tj /Span<>> BDC ( )Tj EMC (\022\030\017\021\036\030\017\005 \233)Tj 0 Tw 5.83 0 0 5.83 272.3938 496.7778 Tm (2)Tj -0.009 Tw 10 0 0 10 275.3088 493.4478 Tm ( \007\035\016 )Tj 0 Tw -20.444 -1.218 Td (\021\026\002\035\017\006 \002\024\035\034\001\036\005 \030\026\n\036\030\ \027\024\f\021\017.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 70.936 444.7358 Tm [(\033\034\020)21(\223)50(\r\241)46(\024)52(\026)45(\024\232)]TJ 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0 Tc 0.263 Tw 10 0 0 10 70.8661 420.3798 Tm (\200 \023\036\030\017\024\007 \r\t\023\024\035\027\036\027\017\016 \017\f\ \f\035\036\007\024\r\026\027\017\016 \023\036\030\017\026\027\026\035\034\ \027\026\016 )Tj -0.028 Tw T* [(\017\027\235\036\022\006\017\016 )0.6(\002\t\035\026 )0.5(\007\017\026\020\027\024\f\021\017\030\024\r\026\027\026 )0.5(\031)]TJ /Span<>> BDC ( )Tj EMC 14.549 0 Td [(78 )0.5(\023\026\006\017\036\027\021\024\r )0.6(\f)]TJ /Span<>> BDC ( )Tj EMC 6.372 0 Td (\020\036)Tj 0 Tw (-)Tj 0.105 Tw -20.921 -1.218 Td (\n\024\002\035\026\f\021\024\026\n\017 \(34 \n\031\032\004\017\027 \017\ )Tj /Span<>> BDC ( )Tj EMC (44 \032\036\027\013\017\027\t\). \204\036\007\017\026\027\026 )Tj 0.068 Tw T* (\r\024\030\026\f\021\026 \002\024\035\034\027\t\b \024\f\021\026\r\017\035\ \026 41 \035\036\021 \(\024\021 18 \007\024)Tj /Span<>> BDC ( )Tj EMC (69 \035\036\021\). )Tj 0.193 Tw T* [(\203\026\017\002\024\035\034\001\036\036 \022\024\035\017\004\036\f\021\r\ \024 )0.5(\023\026\006\017\036\027\021\024\r \r)]TJ /Span<>> BDC ( )Tj EMC (\017\f\f\035\036\007\024\r\026\027\017\017 )Tj 0.158 Tw T* (\002\t\035\024 \f)Tj /Span<>> BDC ( )Tj EMC (\024\f\021\030\t\n\017 \035\036\005\022\024\026\n\017 \(\210\204\214)Tj /Span<>> BDC ( )Tj EMC (\227 47,4%, \210\214\214)Tj /Span<>> BDC ( )Tj EMC (\227 )Tj -0.095 Tw T* [(12,8%\) )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 3.607 0 Td [(\027\036\b\024\007\032\022\017\027\f\022\017\n\017 )0.6(\035\017\n\235\024\n\026\n\017 )0.6(\(21,8%\). )0.5(\221\026\n\t\n )]TJ 0.111 Tw -3.607 -1.218 Td (\004\026\f\021\t\n \023\030\024\016\r\035\036\027\017\036\n \215\222 \002\ \t\035\017 \017\027\235\017\035\034\021\030\026\021\t \(53,8%\) )Tj 0 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\023\026\030\026\030\036\022\021\026\035\034\027\t\036 \026\002\f\006\036\ \f\f\t \(26,9%\) \(\230\026\002\035.)Tj /Span<>> BDC ( )Tj EMC (1\).)Tj 0.223 Tw T* (\221\205\215 \002\t\035\017 \007\017\026\020\027\024\f\021\017\030\024\r\ \026\027\t \031)Tj /Span<>> BDC ( )Tj EMC (7)Tj /Span<>> BDC ( )Tj EMC (\(8,97%\) \017)Tj /Span<>> BDC ( )Tj EMC (78 \023\026)Tj 0 Tw (-)Tj 0.269 Tw T* (\006\017\036\027\021\024\r \(\230\026\002\035.)Tj /Span<>> BDC ( )Tj EMC (2\). \222)Tj /Span<>> BDC ( )Tj EMC (\027\017\b \031)Tj /Span<>> BDC ( )Tj EMC (5 \023\026\006\017\036\027\021\024\r \024\021\n\036\004\036)Tj 0 Tw (-)Tj 0.554 Tw T* [(\027\024 )0.5(\235\024\030\n\017\030\024\r\026\027\017\036 )0.6(\023\036\035\034\r\017\024\030\036\022\021\026\035\034\027\t\b )0.6(\026\002\f\006\036\f\f\024\r, )]TJ -0.014 Tw T* (\031)Tj /Span<>> BDC ( )Tj EMC (2)Tj /Span<>> BDC ( )Tj EMC (\227 \023\024\030\026\032\036\027\017\036 \023\036\035\034\r\017\024\030\ \036\022\021\026\035\034\027\024\005 \022\035\036\021\004\026\021\022\017\ \002\t\035\024 )Tj 0.061 Tw T* (\023\030\036\007\f\021\026\r\035\036\027\024 \235\035\036\020\n\024\027\024\ \005. \025\030\024\n\036 \021\024\020\024, \031)Tj /Span<>> BDC ( )Tj EMC (2 \023\026\006\017\036\027\021\024\r )Tj 0.263 Tw T* [(\r\t\016\r\035\036\027\026 )0.6(\023\036\030\235\024\030\026\006\017\016 )0.5(\023\030\016\n\024\005 )0.6(\022\017\001\022\017 )0.5(\r\t\001\036 )0.5(\031\002\004\026)]TJ 0 Tw (-)Tj 0.155 Tw T* (\021\024\005 \035\017\027\017\017, \031)Tj /Span<>> BDC ( )Tj EMC (1)Tj /Span<>> BDC ( )Tj EMC (\227 \030\036\022\021\024\r\026\020\017\027\026\035\034\027\t\005 \f\r\017\ \013. \200\024\030\026\f\021 )Tj 0.142 Tw T* (\023\026\006\017\036\027\021\024\r \r)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\005 \020\030\031\023\023\036 \f\024\f\021\026\r\035\016\035\ \024\021 33 \007\024)Tj /Span<>> BDC ( )Tj EMC (63 \035\036\021 )Tj 0.229 Tw T* [(\(\n\036\007\017\026\027\026 )0.5(49\), \n\031\032\004\017\027)]TJ /Span<>> BDC ( )Tj EMC 9.971 0 Td [(\227 4, )0.5(\032\036\027\013\017\027)]TJ /Span<>> BDC ( )Tj EMC 6.412 0 Td [(\227 3. )0.5(\210\f\021\030\t\005 )]TJ 0.329 Tw -16.382 -1.218 Td (\n\017\036\035\024\017\007\027\t\005 \035\036\005\022\024 \007\017\026\020\ \027\024\f\021\017\030\024\r\026\027 \031)Tj /Span<>> BDC ( )Tj EMC (3 \002\024\035\034\027\t\b, )Tj 0.205 Tw T* (\024\f\021\030\t\005 \035\017\n\235\024\002\035\026\f\021\027\t\005 \035\ \036\005\022\024)Tj /Span<>> BDC ( )Tj EMC (\227 \031)Tj /Span<>> BDC ( )Tj EMC (2, \027\036\b\024\007\032\022\017\027)Tj 0 Tw (-)Tj T* (\f\022\017\036 \035\017\n\235\024\n\t)Tj /Span<>> BDC ( )Tj EMC (\227 \031)Tj /Span<>> BDC ( )Tj EMC (2.)Tj 0.018 Tw T* [(\203\036\220\235\235\036\022\021\017\r\027\024\f\021\034 )0.6(\035\036\004\036\027\017\016 )0.6(\215\222 )0.5(\027\026)]TJ /Span<>> BDC ( )Tj EMC 14.005 0 Td [(\023\030\036\007\t\007\031\013\017\b )0.6(\220\021\026\023\026\b )]TJ 0.06 Tw -14.005 -1.218 Td (\002\t\035\026 \023\030\017\004\017\027\024\005 \030\026\r\017\021\017\016\ \221\205\215 \031)Tj /Span<>> BDC ( )Tj EMC (6 \(85,7%\) \017)Tj /Span<>> BDC ( )Tj EMC (7 \023\026\006\017)Tj 0 Tw (-)Tj 0.198 Tw T* (\036\027\021\024\r. \230\026\022, \031)Tj /Span<>> BDC ( )Tj EMC (4 \023\026\006\017\036\027\021\024\r \024\021\n\036\004\036\027\024 \235\ \024\030\n\017\030\024\r\026\027\017\036 )Tj 0.299 Tw T* (\023\036\035\034\r\017\024\030\036\022\021\026\035\034\027\t\b \026\002\f\ \006\036\f\f\024\r \027\026)Tj /Span<>> BDC ( )Tj EMC (\235\024\027\036 \026\027\021\017\002\026\022\021\036)Tj 0 Tw (-)Tj 0.492 Tw T* [(\030\017\026\035\034\027\024\005 \021\036\030\026\023\017\017 )0.5(\017\027\235\017\035\034\021\030\026\021\017\r\027\t\b )0.5(\235\024\030\n \023\026\030\026)]TJ 0 Tw (-)Tj 0.092 Tw T* (\023\030\024\022\021\017\021\026, \031)Tj /Span<>> BDC ( )Tj EMC (2)Tj /Span<>> BDC ( )Tj EMC (\227 \023\030\024\020\030\036\f\f\017\030\024\r\026\027\017\036 \020\027\ \024\005\027\024-\r\024\f\023\026\035\017)Tj 0 Tw (-)Tj 0.116 Tw T* (\021\036\035\034\027\024\020\024 \023\030\024\006\036\f\f\026 \017)Tj /Span<>> BDC ( )Tj EMC (\030\026\r\017\021\017\036 \235\035\036\020\n\024\027\t \021\026\026 \023\ \024\f\035\036 )Tj 0.476 Tw T* (\024\023\036\030\026\021\017\r\027\024\020\024 \035\036\004\036\027\017\016\ \023\026\030\026\030\036\022\021\026\035\034\027\t\b \026\002\f\006\036\ \f\f\024\r )Tj 0.043 Tw 23.244 36.534 Td (\(\r\t\023\024\035\027\036\027\027\024\020\024 \r)Tj /Span<>> BDC ( )Tj EMC (\007\030\031\020\017\b \035\036\004\036\002\027\t\b \031\004\030\036\032\ \007\036\027\017\016\b\) \002\036 )Tj 0.087 Tw T* (\026\007\036\022\r\026\021\027\024\005 \026\027\021\017\002\026\022\021\036\ \030\017\026\035\034\027\024\005 \021\036\030\026\023\017\017 \r)Tj /Span<>> BDC ( )Tj EMC (\023\024\f\035\036\024\023\036)Tj 0 Tw (-)Tj 0 -1.218 TD (\030\026\006\017\024\027\027\024\n \023\036\030\017\024\007\036.)Tj -0.017 Tw 0 -1.218 TD (\211 \r\f\036\b \023\026\006\017\036\027\021\024\r \030\026\r\017\021\017\ \036 \221\205\215 \023\030\024\017\f\b\024\007\017\035\024 \027\026)Tj /Span<>> BDC ( )Tj EMC (\235\024\027\036 )Tj 0.041 Tw 0 -1.218 TD (\027\036\005\021\030\024\023\036\027\017\017 \(\027\036\005\021\030\024\235\ \017\035\t)Tj /Span<>> BDC ( )Tj EMC (\252)Tj /Span<>> BDC ( )Tj EMC (500)Tj /Span<>> BDC ( )Tj EMC (\327)Tj /Span<>> BDC ( )Tj EMC (10)Tj 0 Tw 5.83 0 0 5.83 461.1252 399.3539 Tm (9)Tj 0.041 Tw 10 0 0 10 464.0402 396.0239 Tm (/\035\); \r)Tj /Span<>> BDC ( )Tj EMC (3 \f\035\031\004\026)Tj 0 Tw (-)Tj 0.076 Tw -16.073 -1.218 Td [(\016\b )0.5(\026\020\030\026\027\031\035\024\006\017\021\024 )0.6(\002\t\035 )0.5(\024\023\031\b\024\035\036\r\t\n, )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 15.769 0 Td (4)Tj /Span<>> BDC ( )Tj EMC 0.808 0 Td [(\227 )0.5(\n\017\036\035\024\021\024\022)]TJ 0 Tw (-)Tj 0.084 Tw -16.578 -1.218 Td (\f\017\004\036\f\022\017\n \027\026)Tj /Span<>> BDC ( )Tj EMC (\235\024\027\036 \023\030\024\r\036\007\036\027\017\016 \022\031\030\f\024\ \r \017\027\007\031\022\006\017\017 \017\035\017 )Tj 0.124 Tw 0 -1.218 TD (\022\024\027\f\024\035\017\007\026\006\017\017 \021\036\030\026\023\017\017\ \024\f\021\030\t\b \035\036\005\022\024\024\r. \203\026)Tj /Span<>> BDC ( )Tj EMC (\n\024\n\036\027\021 )Tj 0.422 Tw T* (\007\017\026\020\027\024\f\021\017\022\017 \023\026\030\026\023\030\024\022\ \021\017\021\026 \235\036\002\030\017\035\034\027\026\016 \035\017\b\024\ \030\026\007\022\026 )Tj 0.112 Tw T* [(\r\t\016\r\035\036\027\026 )0.5(\031)]TJ /Span<>> BDC ( )Tj EMC 5.086 0 Td [(5 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 2.134 0 Td [(7 )0.5(\023\026\006\017\036\027\021\024\r, )0.6(\031)]TJ /Span<>> BDC ( )Tj EMC 6.485 0 Td (\007\r\024\017\b)Tj /Span<>> BDC ( )Tj EMC 2.775 0 Td [(\227 )0.5(\027\024\030\n\024\021\036\030)]TJ 0 Tw (-)Tj 0.041 Tw -16.481 -1.218 Td (\n\017\016 \(\r \024\007\027\024\n \f\035\031\004\026\036 \027\026)Tj /Span<>> BDC ( )Tj EMC (\235\024\027\036 \023\030\017\036\n\026 \203\215\200\221, \r)Tj /Span<>> BDC ( )Tj EMC (\007\030\031\020\024\n )Tj 0.612 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC 1.818 0 Td [(\235\024\027\036 )0.5(\n\027\024\020\024\022\024\n\023\024\027\036\027\021\027\024\005 )0.6(\026\027\021\017\002\026\022\021\036\030\017\026\035\034\027\024\005 )]TJ 0 Tw -1.818 -1.218 Td (\021\036\030\026\023\017\017\).)Tj -0.019 Tw T* (\221\024\f\021\024\016\027\017\036 \023\026\006\017\036\027\021\024\r \027\ \026)Tj /Span<>> BDC ( )Tj EMC (\n\024\n\036\027\021 \r\t\016\r\035\036\027\017\016 \221\205\215 \002\t\035\ \024 )Tj 0.02 Tw T* (\030\026\f\006\036\027\036\027\024 \022\026\022 \021\016\032\036\035\024\ \036 \017)Tj /Span<>> BDC ( )Tj EMC (\022\030\026\005\027\036 \021\016\032\036\035\024\036 \(3\2264 \002\026\035\ \035\026 )Tj 0.119 Tw T* (\023\024)Tj /Span<>> BDC ( )Tj EMC 1.352 0 Td [(\001\022\026\035\036 )0.5(EC)13(OG\) )0.6(\r)]TJ /Span<>> BDC ( )Tj EMC 6.464 0 Td [(5 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 2.148 0 Td [(7 )0.5(\f\035\031\004\026\036\r. )0.6(\222\027\235\036\022\006\017\017 )0.5(\022\030\024\r\024)]TJ 0 Tw (-)Tj 0.077 Tw -9.965 -1.218 Td (\021\024\022\026 \023\030\017)Tj /Span<>> BDC ( )Tj EMC [(\221\205\215 \r\t\016\r\035\036\027\t )0.5(\031)]TJ /Span<>> BDC ( )Tj EMC [(4 \(57,1%\) )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 16.683 0 Td (7 \023\026\006\017\036\027\021\024\r. )Tj 0.394 Tw -16.683 -1.218 Td (\223\026\f\021\024\021\026 \017\027\235\036\022\006\017\005 \022\030\024\ \r\024\021\024\022\026 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\221\205\215 \f\024\f\021\026\r\017\035\026 )Tj 0.292 Tw T* (57,1% \(4 \017)Tj /Span<>> BDC ( )Tj EMC (7)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r\), \f\021\026\021\017\f\021\017\004\036\ \f\022\017 \027\026\004\017\n\024 )Tj 0 Tw T* (\r\t\001\036, \004\036\n \007\030\031\020\017\b \235\024\030\n\026\b \215\ \222 15,5% \()Tj /T1_3 1 Tf (p)Tj /T1_0 1 Tf /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (0,05\).)Tj 0.242 Tw T* [(\200 )0.5(\f\r\016\017 )0.6(\f)]TJ /Span<>> BDC ( )Tj EMC 4.734 0 Td [(\f\036\023\f\017\f\024\n, )0.5(\027\036\f\021\026\002\017\035\034\027\024\005 )0.5(\020\036\n\024\007\017\027\026\n\017\022\024\005, )]TJ 0.182 Tw -4.734 -1.218 Td (\031\020\030\024\024\005 \030\026\r\017\021\017\016 \f\036\023\021\017\ \004\036\f\022\024\020\024 \001\024\022\026 4)Tj /Span<>> BDC ( )Tj EMC (\(57,1%\) \023\026)Tj 0 Tw (-)Tj 0.097 Tw T* (\006\017\036\027\021\026 \f\024 \221\205\215 \027\026\b\024\007\017\035\017\ \f\034 \r)Tj /Span<>> BDC ( )Tj EMC (\024\021\007\036\035\036\027\017\017 \030\036\026\027\017\n\026\006\017\017\ )Tj 0.342 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\017\027\021\036\027\f\017\r\027\024\005 \021\036\030\026\023\017\017 \(\ \210\217\222\230\). \221\035\036\007\031\036\021 \024\021\n\036\021\017\021\ \034 )Tj 0.243 Tw T* [(\007\035\017\021\036\035\034\027\t\005 )0.6(\f\030\024\022 )0.5(\035\036\004\036\027\017\016 )0.6(\r)]TJ /Span<>> BDC ( )Tj EMC 12.551 0 Td [(\210\217\222\230, )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 3.764 0 Td [(\f\030\036\007\027\036\n, )0.5(32,5 )]TJ 0 Tw -16.315 -1.218 Td (\(17\22654\) \007\027\016 \(\230\026\002\035.)Tj /Span<>> BDC ( )Tj EMC (2\).)Tj 0.163 Tw T* (\221 \006\036\035\034\033 \031\021\024\004\027\036\027\017\016 \235\024\030\ \n\t \r\024\f\023\026\035\036\027\017\016 \017\035\017 \035\024\022\026\035\ \017)Tj 0 Tw (-)Tj 0.223 Tw T* (\026\006\017\017 \023\026\021\024\035\024\020\017\004\036\f\022\024\020\ \024 \024\004\026\020\026 \204\217\230 \002\t\035\026 \r\t\023\024\035\027\ \036\027\026 )Tj 0.195 Tw T* (24)Tj /Span<>> BDC ( )Tj EMC (\(30,8%\) \017)Tj /Span<>> BDC ( )Tj EMC (78 \023\026\006\017\036\027\021\024\r. \221\035\036\007\031\036\021 \024\ \021\n\036\021\017\021\034, \004\021\024 )Tj 0.163 Tw T* (\023\030\017)Tj /Span<>> BDC ( )Tj EMC (\007\017\026\020\027\024\f\021\017\022\036 \221\205\215 \007\026\027\027\ \t\036 \023\024\035\031\004\036\027\027\t\036 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\024\002\255)Tj 0 Tw (-)Tj 0.176 Tw T* (\036\022\021\017\r\027\024\005 \r\017\031\026\035\017\026\006\017\017 \ \024\021\035\017\004\026\035\017\f\034 \024\021 \022\035\017\027\017\004\ \036\f\022\024\005 )Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0.232 Tw 9 0 0 9 303.3071 730.483 Tm (\020\004\206\f\t\204\004 1.)Tj 0 0 0 1 k /GS1 gs /T1_3 1 Tf ( \206\026\032\026\013\024\031\032\025\t\024\025\013\025 \033\026\203\025\ \031\021\024\n\027 \t)Tj /Span<>> BDC ( )Tj EMC (\033\031\032\025\026\021\026\023\022\021\n\017 )Tj 0 Tw 0 -1.2 TD (\025\021\f\031\013\203\025\031\017)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf T* [(T)48(able 1)47(.)]TJ 0 0 0 1 k /GS1 gs /T1_3 1 Tf [( Character)-36.9(istics of patients with per)-36.7(ianal infection)]TJ ET 0 0 0 1 K 0.5 w /GS2 gs q 1 0 0 1 303.3071 704.381 cm 0 0 m 155.593 0 l S Q q 1 0 0 1 303.5571 683.5618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 458.9003 704.381 cm 0 0 m 65.509 0 l S Q q 1 0 0 1 458.9003 683.5618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 524.1594 683.5618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 303.3071 683.3118 cm 0 0 m 155.593 0 l S Q q 1 0 0 1 303.5571 672.1005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 458.9003 683.3118 cm 0 0 m 65.509 0 l S Q q 1 0 0 1 458.9003 672.1005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.1594 672.1005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 303.3071 671.8505 cm 0 0 m 155.593 0 l S Q q 1 0 0 1 303.5571 660.6392 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 458.9003 671.8505 cm 0 0 m 65.509 0 l S Q q 1 0 0 1 458.9003 660.6392 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.1594 660.6392 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 303.3071 660.3892 cm 0 0 m 155.593 0 l S Q q 1 0 0 1 303.5571 649.1779 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 458.9003 660.3892 cm 0 0 m 65.509 0 l S Q q 1 0 0 1 458.9003 649.1779 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.1594 649.1779 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 303.3071 648.9279 cm 0 0 m 155.593 0 l S Q q 1 0 0 1 303.5571 580.1087 cm 0 0 m 0 68.569 l S Q q 1 0 0 1 458.9003 648.9279 cm 0 0 m 65.509 0 l S Q q 1 0 0 1 458.9003 580.1087 cm 0 0 m 0 68.569 l S Q q 1 0 0 1 524.1594 580.1087 cm 0 0 m 0 68.569 l S Q q 1 0 0 1 303.3071 579.8587 cm 0 0 m 155.593 0 l S Q q 1 0 0 1 303.5571 491.8395 cm 0 0 m 0 87.769 l S Q q 1 0 0 1 458.9003 579.8587 cm 0 0 m 65.509 0 l S Q q 1 0 0 1 458.9003 491.8395 cm 0 0 m 0 87.769 l S Q q 1 0 0 1 524.1594 491.8395 cm 0 0 m 0 87.769 l S Q q 1 0 0 1 303.3071 491.5895 cm 0 0 m 155.593 0 l S Q q 1 0 0 1 458.9003 491.5895 cm 0 0 m 65.509 0 l S Q BT /GS1 gs /T1_1 1 Tf 8 0 0 8 361.285 690.9464 Tm (\200\002\220\004\213\004\003\r\f\001)Tj -0.021 Tw 12.556 0.6 Td (\030\t\217\f\002 \212\004\204\t\r\b\003\002 )Tj /T1_4 1 Tf 0 Tw 2.488 -1.2 Td (n)Tj /T1_1 1 Tf ( \(%\))Tj /T1_0 1 Tf -21.906 -1.433 Td (\223\017\f\035\024 \023\026\006\017\036\027\021\024\r)Tj 22.642 0 Td (78)Tj -22.642 -1.433 Td (\215\024\035 \n/\032)Tj 21.921 0 Td (34/44)Tj -21.921 -1.433 Td (\200\024\030\026\f\021 \n\036\007\017\026\027\026 \(\007\017\026\023\026\ \024\027\) \035\036\021)Tj 20.878 0 Td (41)Tj /Span<>> BDC ( )Tj EMC (\(18\22669\))Tj /T1_1 1 Tf -20.878 -1.434 Td (\031\t\004\n\b\002\213:)Tj /T1_0 1 Tf T* (\210\f\021\030\t\036 \n\017\036\035\024\017\007\027\t\036 \035\036\005\022\ \024\t)Tj 0 -1.2 TD (\210\f\021\030\t\005 \035\017\n\235\024\002\035\026\f\021\027\t\005 \035\ \036\005\022\024)Tj 0 -1.2 TD (\203\036\b\024\007\032\022\017\027\f\022\017\036 \035\017\n\235\024\n\t)Tj 0 -1.2 TD (\214\017\n\235\024\n\026 \216\024\007\032\022\017\027\026)Tj 0 -1.2 TD (\204\027\024\032\036\f\021\r\036\027\027\026\016 \n\017\036\035\024\n\026\ )Tj 0 -1.2 TD (\215\030\024\004\017\036)Tj 21.313 6.001 Td (37)Tj /Span<>> BDC ( )Tj EMC (\(47,4\))Tj T* (10)Tj /Span<>> BDC ( )Tj EMC (\(12,8\))Tj T* (17)Tj /Span<>> BDC ( )Tj EMC (\(21,8\))Tj 0.5 -1.2 Td (5)Tj /Span<>> BDC ( )Tj EMC (\(6,4\))Tj 0 -1.2 TD (4)Tj /Span<>> BDC ( )Tj EMC (\(5,1\))Tj 0 -1.2 TD (5)Tj /Span<>> BDC ( )Tj EMC (\(6,4\))Tj /T1_1 1 Tf -21.813 -1.435 Td (\021\f\t\b\t\201\r\217\220\t\r \212\006\002\235\f\r\b\t\235 \200\034:)Tj /T1_0 1 Tf 0 -1.2 TD (\222\027\235\017\035\034\021\030\026\021\t)Tj 0 -1.2 TD (\215\026\030\026\030\036\022\021\026\035\034\027\t\036 \026\002\f\006\036\ \f\f\t, \017)Tj /Span<>> BDC ( )Tj EMC (\027\017\b)Tj 0 -1.2 TD (\023\036\035\034\r\017\024\030\036\022\021\026\035\034\027\t\036)Tj 0 -1.2 TD (\221\r\017\013\017 \023\030\016\n\024\005 \022\017\001\022\017)Tj 0 -1.2 TD (\217\036\022\021\024\r\026\020\017\027\026\035\034\027\t\036 \f\r\017\013\ \017)Tj 0 -1.2 TD (\215\036\030\235\024\030\026\006\017\017 \022\017\001\022\017 \r\t\001\036\ \031\002\004\026\021\024\005 \035\017\027\017\017)Tj 0 -1.2 TD (\215\024\030\026\032\036\027\017\016 \023\036\030\017\026\027\026\035\034\ \027\024\005 \022\024\032\017 \(\016\r\t, )Tj 0 -1.2 TD (\220\030\024\017\017, \027\036\022\030\024\t\))Tj 21.313 8.401 Td (42)Tj /Span<>> BDC ( )Tj EMC (\(53,8\))Tj 0 -1.2 TD (21)Tj /Span<>> BDC ( )Tj EMC (\(26,9\))Tj 0.5 -1.2 Td (7)Tj /Span<>> BDC ( )Tj EMC (\(8,9\))Tj -0.25 -1.2 Td (8)Tj /Span<>> BDC ( )Tj EMC (\(10,3\))Tj 0.25 -1.2 Td (1)Tj /Span<>> BDC ( )Tj EMC (\(1,3\))Tj 0 -1.2 TD (2)Tj /Span<>> BDC ( )Tj EMC (\(2,6\))Tj 0 -1.2 TD (7)Tj /Span<>> BDC ( )Tj EMC (\(8,9\))Tj /T1_3 1 Tf 7 0 0 7 303.3071 480.1048 Tm (\032\025\003\031\006\026\021\025\031: * \004\032\n\021\025\006\031\t\013\ \025\017 \003\025\031\023\n\025\030\021\020\017 \023\031\017\013\n\016 n\ )Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (3, \004\032\n\021\025\006\031\t\013\025\017 )Tj 0 -1.2 TD (\023\025\003\f\n\023\031\017\013\n\016 n)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (2)Tj 1 0.68 0 0.12 k /GS0 gs /T1_5 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\033\030\031\030\213\b)-20.9(\035\231\213\233\t \021\032)50(\b)42(\032\231\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj -51.938 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 23, \023\0221)69(, 202)69(4)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 23, \023\0221)69(, 202)69(4)]TJ /T1_6 1 Tf 25 0 0 25 20.7653 56.0378 Tm (120)Tj ET endstream endobj 1216 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\255\220\013\202\001\025\006)-9.9(\026\220\n\013 \220\022\007\016\017\016\001\220\016 \006)-10(\007\025\217\001\020\207 \225\025\002\024 \025\006)-10(\026\002\025\202)10(\025 \221\013\002\013\221\002\025\n)-10(\026\220\026)11(\013 )]TJ 0 -1 TD [(\215\022\221\013\227\220\016\001\026)11.1(\025\r \006\022\025\221\215)21(\207\025\007\016\r\020\024\220 \222\013\f\025\007\016\r\013\001\220\205\024\ \220 \006\220\006)-10(\026)11(\016\024\020 \n\002\025\r\220)]TJ 40.547 1 Td [(Diagnostics and tr)31(eatment of complicated perianal )]TJ 0.208 -1 Td [(abscess in patients with h)11(ematologic malignancies)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0.14 Tw 10 0 0 10 42.5197 724.8299 Tm [(\035\036\004\036\027\017\036 )0.5(\023\026\006\017\036\027\021\024\r )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC [(\020\036\n\024\002\035\026\f\021\024\026\n\017 )0.5(\f\r\016\026\027\024 \f)]TJ /Span<>> BDC ( )Tj EMC (\030\017)Tj 0 Tw (-)Tj 0.161 Tw 0 -1.218 TD (\f\022\024\n \007\017\f\f\036\n\017\027\026\006\017\017 \017\027\235\036\ \022\006\017\017. \223\026\f\021\024\021\026 \f\036\023\f\017\f\026 \f\024\ )Tj 0 Tw (-)Tj 0.095 Tw T* (\f\021\026\r\035\016\036\021 20\22633% [4,8]. \203\026\030\031\001\036\027\ \017\036 \235\031\027\022\006\017\017 \022\035\036\021\024\004)Tj 0 Tw (-)Tj 0.153 Tw T* (\027\024\020\024 \017\n\n\031\027\017\021\036\021\026 \016\r\035\016\036\ \021\f\016 \023\030\017\004\017\027\024\005 \021\026\022\017\b \023\030\024\ \002\035\036\n )Tj 0.112 Tw T* [(\023\024\f\035\036\024\023\036\030\026\006\017\024\027\027\024\020\024 )0.5(\023\036\030\017\024\007\026, \022\026\022 \024\021\f\031\021\f\021\r\017\ \036 \024\021\020\030\026)]TJ 0 Tw (-)Tj -0.085 Tw T* (\027\017\004\036\027\017\016 \017\027\235\036\022\006\017\017 \017)Tj /Span<>> BDC ( )Tj EMC (\030\036\023\026\030\026\006\017\017 \030\026\027. \210\023\031\002\035\017\ \022\024\r\026\027\027\t\036 )Tj -0.002 Tw 0 -1.218 TD (\017\f\f\035\036\007\024\r\026\027\017\016 \023\030\036\007\f\021\026\r\035\ \016\033\021 \f\031\n\n\026\030\027\t\036 \007\026\027\027\t\036 \024)Tj /Span<>> BDC ( )Tj EMC (\030\036)Tj 0 Tw (-)Tj 0.413 Tw 0 -1.218 TD (\031\035\034\021\026\021\026\b \035\036\004\036\027\017\016 \024\027\022\ \024\020\036\n\026\021\024\035\024\020\017\004\036\f\022\017\b \002\024\035\ \034\027\t\b )Tj 0.387 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\030\026\035\017\004\027\t\n\017 \235\024\030\n\026\n\017 \023\036\030\017\ \026\027\026\035\034\027\024\005 \017\027\235\036\022\006\017\017. )Tj 0.432 Tw T* (\222\f\f\035\036\007\024\r\026\027\017\016, \024\f\r\036\013\026\033\013\ \017\036 \r\024\023\030\024\f\t \007\017\026\020\027\024\f\021\017\022\017\ )Tj 0.099 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\035\036\004\036\027\017\016 \221\205\215 \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\020\036\n\024\002\035\026\f\021\024\026\n\017, \r)Tj /Span<>> BDC ( )Tj EMC (\035\017)Tj 0 Tw (-)Tj 0.302 Tw T* [(\021\036\030\026\021\031\030\036 \027\036 \023\030\036\007\f\021\026\r\035\ \036\027\t. )0.5(\202\022\021\031\026\035\034\027\t\n\017 \026\007\026\004\026\n\017 )]TJ 0.136 Tw 0 -1.218 TD (\016\r\035\016\033\021\f\016: \030\026\030\026\002\024\021\022\026 \007\ \024\f\021\024\r\036\030\027\t\b \022\030\017\021\036\030\017\036\r \007\ \017\026\020)Tj 0 Tw (-)Tj 0.051 Tw 0 -1.218 TD (\027\024\f\021\017\022\017 \017)Tj /Span<>> BDC ( )Tj EMC (\024\006\036\027\022\017 \007\017\027\026\n\017\022\017 \021\036\004\036\ \027\017\016 \017\027\235\036\022\006\017\024\027\027\024\020\024 )Tj -0.034 Tw 0 -1.218 TD (\023\030\024\006\036\f\f\026 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\221\205\215; \017\031\004\036\027\017\036 \030\026\006\017\024\027\026\ \035\034\027\024\005 \f\021\030\026\021\036\020\017\017 )Tj 0.43 Tw T* (\026\027\021\017\002\026\022\021\036\030\017\026\035\034\027\024\005 \021\ \036\030\026\023\017\017; \024\006\036\027\022\026 \r\024\n\024\032\027\ \024\f\021\017 )Tj 0.05 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\220\235\235\036\022\021\017\r\027\024\f\021\017 \023\030\017\n\036\027\036\ \027\017\016 \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\027\036\005\021\030\024)Tj 0 Tw (-)Tj 0.113 Tw T* (\023\036\027\017\036\005 \f\024\r\030\036\n\036\027\027\t\b \n\036\021\024\ \007\024\r \035\036\004\036\027\017\016 \020\027\024\005\027\t\b \030\026\ \027, )Tj 0 Tw T* (\021\026\022\017\b \022\026\022 \020\017\007\030\024\017\n\023\031\035\034\ \f\027\026\016 \017)Tj /Span<>> BDC ( )Tj EMC (\r\026\022\031\031\n-\021\036\030\026\023\017\016 [9,10].)Tj 0.327 Tw T* (\200\026\032\027\036\005\001\017\n \026\f\023\036\022\021\024\n \017\f\f\ \035\036\007\024\r\026\027\017\016 \016\r\035\016\036\021\f\016 \r\024)Tj 0 Tw (-)Tj 0.32 Tw T* (\n\024\032\027\024\f\021\034 \023\030\024\r\036\007\036\027\017\016 \023\ \030\024\021\017\r\024\024\023\031\b\024\035\036\r\024\005 \021\036\030\026\ \023\017\017 )Tj 0.243 Tw T* (\031)Tj /Span<>> BDC ( )Tj EMC 0.92 0 Td [(\007\026\027\027\024\005 )0.6(\022\026\021\036\020\024\030\017\017 )0.5(\023\026\006\017\036\027\021\024\r. )0.6(\215\024\n\017\n\024 )0.5(\027\036\023\024\f\030\036\007)]TJ 0 Tw (-)Tj 0.03 Tw -0.92 -1.218 Td (\f\021\r\036\027\027\024\005 \031\020\030\024\t \007\035\016 \032\017\027\ \017 \023\026\006\017\036\027\021\026 \017\027\235\036\022\006\017\024\027\ \027\t\036 )Tj 0.197 Tw T* (\024\f\035\024\032\027\036\027\017\016, \021\030\036\002\031\033\013\017\ \036 \007\035\017\021\036\035\034\027\024\020\024 \035\036\004\036\027\017\ \016, \023\030\036)Tj 0 Tw (-)Tj 0.497 Tw T* (\023\016\021\f\021\r\031\033\021 \030\036\026\035\017\026\006\017\017 \023\ \030\024\020\030\026\n\n \006\017\021\024\f\021\026\021\017\004\036\f\022\ \024\005 )Tj 0.165 Tw T* (\021\036\030\026\023\017\017 \017)Tj /Span<>> BDC ( )Tj EMC (\024\022\026\t\r\026\033\021 \027\036\020\026\021\017\r\027\024\036 \r\035\ \017\016\027\017\036 \027\026)Tj /Span<>> BDC ( )Tj EMC (\024\027\022\024)Tj 0 Tw (-)Tj 0.166 Tw T* (\035\024\020\017\004\036\f\022\017\005 \023\030\024\020\027\024 [11]. \215\ \024)Tj /Span<>> BDC ( )Tj EMC (\007\026\027\027\t\n \017\f\f\035\036\007\024\r\026\027\017\016 )Tj 0.223 Tw T* [(S)-16(olma)-23.9(z S. \f)]TJ /Span<>> BDC ( )Tj EMC (\f\024\026\r\021., \027\026\035\017\004\017\036 \026\027\024\030\036\022\ \021\026\035\034\027\t\b \024\f\035\024\032)Tj 0 Tw (-)Tj 0.303 Tw T* (\027\036\027\017\005 \031\r\036\035\017\004\017\r\026\036\021 \023\024\022\ \026\026\021\036\035\034 \024\002\013\036\005 \035\036\021\026\035\034\027\ \024\f\021\017 )Tj 0.01 Tw T* (\031)Tj /Span<>> BDC ( )Tj EMC [(\024\027\022\024\020\036\n\026\021\024\035\024\020\017\004\036\f\022\017\ \b )0.6(\023\026\006\017\036\027\021\024\r \f)]TJ /Span<>> BDC ( )Tj EMC 15.557 0 Td (22,2% \007\024)Tj /Span<>> BDC ( )Tj EMC 3.924 0 Td (41,2%, )Tj 0.292 Tw -19.481 -1.218 Td (\026)Tj /Span<>> BDC ( )Tj EMC (\023\030\017 \026\022\021\017\r\027\024\n \024\023\031\b\024\035\036\r\024\ \n \026\002\024\035\036\r\026\027\017\017 \f\017\f\021\036\n\t )Tj 0 Tw T* (\022\030\024\r\017 \036\020\024 \027\026\004\036\027\017\036 \007\024\f\ \021\017\020\026\036\021 60,9% [4].)Tj 0.162 Tw T* (\025\024\027\006\036\027\021\030\026\006\017\016 \002\024\035\034\027\t\b\ \f)Tj /Span<>> BDC ( )Tj EMC (\024\023\031\b\024\035\016\n\017 \f\017\f\021\036\n\t \022\030\024\r\017\ )Tj 0.105 Tw T* [(\023\024\r\024\035\016\036\021 )0.5(\027\026)]TJ /Span<>> BDC ( )Tj EMC 5.845 0 Td [(\002\024\035\034\001\024\n )0.5(\004\017\f\035\036 )0.5(\022\035\017\027\017\004\036\f\022\017\b )0.5(\027\026\002\035\033\007\036)]TJ 0 Tw (-)Tj 0.103 Tw -5.845 -1.218 Td (\027\017\005 \023\030\024\026\027\026\035\017\017\030\024\r\026\021\034\ \026\f\023\036\022\021\t \007\017\026\020\027\024\f\021\017\022\017 \017\ )Tj /Span<>> BDC ( )Tj EMC (\035\036\004\036)Tj 0 Tw (-)Tj T* (\027\017\016 \221\205\215 \031)Tj /Span<>> BDC ( )Tj EMC (\007\026\027\027\024\005 \022\026\021\036\020\024\030\017\017 \023\026\006\ \017\036\027\021\024\r.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.01 Tc 0.018 Tw 14 0 0 14 42.5896 262.0658 Tm [(\017\034\r\241)5( \031\032\032\r\034\226\037\023\026\022\031\025)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0 Tc -0.009 Tw 10 0 0 10 42.5197 237.7098 Tm (\217\026\030\026\002\024\021\026\021\034 \026\035\020\024\030\017\021\n\ \007\017\026\020\027\024\f\021\017\022\017 \017)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\021\017\022\031 \035\036\004\036\027\017\016 )Tj 0.336 Tw T* (\f\035\024\032\027\t\b \235\024\030\n \023\026\030\026\023\030\024\022\021\ \017\021\026 \031)Tj /Span<>> BDC ( )Tj EMC (\024\027\022\024\020\036\n\026\021\024\035\024\020\017\004\036)Tj 0 Tw (-)Tj T* (\f\022\017\b \002\024\035\034\027\t\b.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.01 Tc 0.018 Tw 14 0 0 14 42.5896 176.8198 Tm [(\f\026\017\031\034\022\024\232)5( \031)5(\016)-18.3(\240\034)-31(\024)35(\037\226\232)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0.016 Tc 0.199 Tw 10 0 0 10 42.5197 152.4638 Tm (\200 \017\f\f\035\036\007\024\r\026\027\017\036, \r\t\023\024\035\027\036\ \027\027\024\036 \r)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\017\024\007 \f)Tj /Span<>> BDC ( )Tj EMC [(\016\027\r\026\030\016)16( )]TJ 0.231 Tw T* [(2021 )0.6(\023\024)]TJ /Span<>> BDC ( )Tj EMC 4.056 0 Td [(\007\036\022\026\002\030\034 )0.5(2022 )0.6(\020\020., )0.5(\002\t\035\017 )0.5(\r\022\035\033\004\036\027\t )0.5(\023\026\006\017)]TJ 0 Tc 0 Tw (-)Tj 0.016 Tc 0.455 Tw -4.056 -1.218 Td (\036\027\021\t \f)Tj /Span<>> BDC ( )Tj EMC [(\031\f\021\026\027\024\r\035\036\027\027\t\n \007\017\026\020\027\024\024\ \n \020\036\n\024\002\035\026\f\021\024\026)16( )]TJ 0.046 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\017\027\235\036\022\006\017\024\027\027\t\n \023\024\030\026\032\036\027\ \017\036\n \n\016\020\022\017\b \021\022\026\027\036\005 \023\036\030\017\ )Tj 0 Tc 0 Tw (-)Tj 0.016 Tc 0.213 Tw T* [(\026\027\026\035\034\027\024\005 \024\002\035\026\f\021\017. \221\035\024\ \032\027\t\036 \235\024\030\n\t \023\026\030\026\023\030\024\022\021\017\ \021\026)16( )]TJ 0.016 Tw T* (\r\t\007\036\035\016\035\017 \023\030\017)Tj /Span<>> BDC ( )Tj EMC [(\027\026\035\017\004\017\017 \f\031\023\030\026\035\036\r\026\021\024\030\ \027\024\020\024 \026\002\f\006\036\f\f\026,)16( )]TJ 0.141 Tw T* [(\235\035\036\020\n\024\027\t \021\026\026, \030\026\030\031\001\036\027\ \017\016 \f\021\036\027\022\017 \023\030\016\n\024\005 \022\017\001\022\017\ )16( )]TJ 0.156 Tw 23.244 64.543 Td [(\r\t\001\036 \031\030\024\r\027\016 \031\002\004\026\021\024\005 \035\017\ \027\017\017, \023\024\030\026\032\036\027\017\016 \021\026\024\r\t\b)16( )]TJ -0.016 Tw 0 -1.218 TD (\024\030\020\026\027\024\r.)Tj 0 Tc 0.045 Tw 0 -1.218 TD (\203\026\035\017\004\017\036 \017\027\235\036\022\006\017\024\027\027\024\ \020\024 \023\030\024\006\036\f\f\026 \r)Tj /Span<>> BDC ( )Tj EMC (\023\026\030\026\030\036\022\021\026\035\034\027\024\005 )Tj 0.137 Tw 0 -1.218 TD (\022\035\036\021\004\026\021\022\036 \017)Tj /Span<>> BDC ( )Tj EMC (\024\002\255\036\n \023\024\030\026\032\036\027\017\016 \024\006\036\027\ \017\r\026\035\f\016 \022\035\017\027\017\004\036)Tj 0 Tw (-)Tj 0.067 Tw T* [(\f\022\017 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 2.533 0 Td [(\023\024 )0.5(\007\026\027\027\t\n )0.5(\n\026\020\027\017\021\027\024-\030\036\024\027\026\027\f\027\024\005 )0.6(\021\024\n\024\020\030\026\235\017\017 )]TJ 0.074 Tw -2.533 -1.218 Td (\(\204\217\230\). \025\035\017\027\017\004\036\f\022\017\n\017 \023\030\017\ \027\026\022\026\n\017 \023\036\030\017\026\027\026\035\034\027\024\005\ \017\027)Tj 0 Tw (-)Tj 0.217 Tw 0 -1.218 TD [(\235\036\022\006\017\017 \f\004\017\021\026\035\017 \027\026\035\017\004\ \017\036 \r\024\f\023\026\035\017\021\036\035\034\027\024\020\024 )0.5(\017\027\235\017\035\034)]TJ 0 Tw (-)Tj -0.007 Tw 0 -1.218 TD (\021\030\026\021\026, \026\002\f\006\036\f\f\026, \027\036\022\030\024\026\ \017\035\017 \023\026\030\026\030\036\022\021\026\035\034\027\024\020\024\ \f\r\017\013\026.)Tj 0.217 Tw T* [(\204\217\230 \024\030\020\026\027\024\r \n\026\035\024\020\024 \021\026\ \026 \r\t\023\024\035\027\016\035\017 )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC (\006\036\035\034\033 \023\024\007)Tj 0 Tw (-)Tj 0.008 Tw T* (\021\r\036\030\032\007\036\027\017\016 \027\026\035\017\004\017\016 \017\ )Tj /Span<>> BDC ( )Tj EMC (\024\023\030\036\007\036\035\036\027\017\016 \035\024\022\026\035\017\026\ \006\017\017 \023\026)Tj 0 Tw (-)Tj 0.037 Tw T* (\030\026\030\036\022\021\026\035\034\027\024\020\024 \026\002\f\006\036\f\ \f\026 \017\035\017 \f\r\017\013\026, \026)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\032\036 \r)Tj /Span<>> BDC ( )Tj EMC (\022\035\017\027\017)Tj 0 Tw (-)Tj 0.076 Tw T* (\004\036\f\022\017 \027\036\016\f\027\t\b \f\017\021\031\026\006\017\016\ \b \031)Tj /Span<>> BDC ( )Tj EMC (\035\017\b\024\030\026\007\016\013\017\b \023\026\006\017\036\027\021\024\ \r. )Tj 0.072 Tw T* (\204\217-\023\030\017\027\026\022\026\n\017 \r\024\f\023\026\035\036\027\ \017\016 \f\004\017\021\026\035\017 \r\t\f\024\022\031\033 \017\027\021\036\ \027)Tj 0 Tw (-)Tj 0.189 Tw T* (\f\017\r\027\024\f\021\034 \f\017\020\027\026\035\026, \024\021\035\017\004\ \027\031\033 \024\021 \017\027\021\036\027\f\017\r\027\024\f\021\017 \027\ \024\030)Tj 0 Tw (-)Tj 0.108 Tw T* (\n\026\035\034\027\t\b \022\030\024\r\036\027\024\f\027\t\b \f\024\f\031\ \007\024\r. \202\002\f\006\036\f\f \024\023\030\036\007\036\035\016\035\017\ )Tj 0.379 Tw T* (\022\026\022 \035\024\022\026\035\017\024\r\026\027\027\024\036 \f\022\024\ \023\035\036\027\017\036 \f)Tj /Span<>> BDC ( )Tj EMC (\017\027\021\036\027\f\017\r\027\024\f\021\034\033 )Tj 0.319 Tw T* (\f\017\020\027\026\035\026, \f\024\024\021\r\036\021\f\021\r\031\033\013\ \036\036 \032\017\007\022\024\f\021\017; \f\r\017\013)Tj /Span<>> BDC ( )Tj EMC (\227 \022\026\022 )Tj 0.275 Tw T* (\021\030\031\002\004\026\021\031\033 \f\021\030\031\022\021\031\030\031 \ \f)Tj /Span<>> BDC ( )Tj EMC (\r\027\031\021\030\036\027\027\017\n \017)Tj /Span<>> BDC ( )Tj EMC (\r\027\036\001\027\017\n \024\021)Tj 0 Tw (-)Tj 0.081 Tw T* [(\r\036\030\f\021\017\036\n. \212\035\016 \007\017\235\235\036\030\036\027\ \006\017\026\035\034\027\024\005 )0.5(\007\017\026\020\027\024\f\021\017\022\017 \030\031\002)]TJ 0 Tw (-)Tj 0.137 Tw T* (\006\024\r\t\b \017\n\036\027\036\027\017\005 \017)Tj /Span<>> BDC ( )Tj EMC (\f\r\017\013\036\005 \017\f\023\024\035\034\024\r\026\035\017 \r\r\036\007\ \036\027\017\036 )Tj 0 Tw T* (\r\027\031\021\030\017\r\036\027\027\024\020\024 \022\024\027\021\030\026\ \f\021\027\024\020\024 \r\036\013\036\f\021\r\026.)Tj 0.162 Tw T* (\230\016\032\036\f\021\034 \f\024\f\021\024\016\027\017\016 \002\024\035\ \034\027\024\020\024 \024\006\036\027\017\r\026\035\026\f\034 \023\024)Tj /Span<>> BDC ( )Tj EMC (\001\022\026\035\036 )Tj 0 Tw T* [(Easter)-15(n Co)-15.9(oper)-33(a)15(t)-32(i)-16(ve Oncol)30.1(o)-16(g)16(y G)20(r)-32(oup \(EC)13.1(OG\) [12].)]TJ 0.266 Tw T* (\221 \006\036\035\034\033 \n\024\027\017\021\024\030\017\027\020\026 \n\017\ \022\030\024\235\035\024\030\t \r\t\023\024\035\027\016\035\017 \n\026)Tj 0 Tw (-)Tj 0.078 Tw T* [(\024\022 )0.5(\017\035\017 )0.5(\002\017\024\023\f\017\033 )0.6(\f)]TJ /Span<>> BDC ( )Tj EMC 8.233 0 Td [(\023\024\r\036\030\b\027\024\f\021\017 )0.6(\030\026\027\t. )0.5(\215\030\017)]TJ /Span<>> BDC ( )Tj EMC 10.174 0 Td (\021\036\n\023\036\030\026)Tj 0 Tw (-)Tj 0.207 Tw -18.407 -1.218 Td (\021\031\030\036 \021\036\035\026 38)Tj /Span<>> BDC ( )Tj EMC 5.583 0 Td (\260\221 \017)Tj /Span<>> BDC ( )Tj EMC (\r\t\001\036 \017\f\f\035\036\007\024\r\026\035\017 \020\036\n\024\022\031\ \035\034\021\031\030\031. )Tj 0.158 Tw -5.583 -1.218 Td (\215\030\017)Tj /Span<>> BDC ( )Tj EMC (\030\026\f\f\n\024\021\030\036\027\017\017 \023\036\030\017\026\027\026\035\ \034\027\024\005 \017\027\235\036\022\006\017\017 \022\026\022 \017\f)Tj 0 Tw (-)Tj 0.354 Tw T* [(\021\024\004\027\017\022\026 \f\036\023\f\017\f\026 )0.5(\031\004\017\021\t\r\026\035\017 \r\017\007\024\r\024\036 \f\024\024\021\ \r\036\021\f\021\r\017\036 )]TJ 0.473 Tw T* (\n\017\022\030\024\024\030\020\026\027\017\n\024\r, \r\t\007\036\035\036\ \027\027\t\b \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\016\n\024\005 \022\017\001\022\017 )Tj 0 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\022\030\024\r\017.)Tj 0.381 Tw T* (\212\030\036\027\017\030\024\r\026\027\017\036 \026\002\f\006\036\f\f\024\ \r \r\t\023\024\035\027\016\035\017 \023\026\030\026\030\036\022\021\026\ \035\034)Tj 0 Tw (-)Tj 0.385 Tw T* (\027\t\n \007\024\f\021\031\023\024\n. \221\017\020\n\024\f\021\024\n\017\ \016 \002\t\035\026 \r\t\023\024\035\027\036\027\026 \023\026)Tj 0 Tw (-)Tj 0.466 Tw T* (\006\017\036\027\021\026\n \f)Tj /Span<>> BDC ( )Tj EMC (\024\002\001\017\030\027\t\n\017 \023\026\030\026\030\036\022\021\026\035\ \034\027\t\n\017 \030\026\027\026\n\017, )Tj 0.146 Tw T* (\021\016\032\036\035\t\n \f\024\n\026\021\017\004\036\f\022\017\n \f\021\ \026\021\031\f\024\n \(4 \002\026\035\035\026 \023\024)Tj /Span<>> BDC ( )Tj EMC (\001\022\026\035\036 )Tj 0.019 Tw T* [(EC)13(OG\), \007\035\017\021\036\035\034\027\024\005 \027\036\005\021\030\024\023\ \036\027\017\036\005, \f\036\023\f\017\f\024\n. \200)]TJ /Span<>> BDC ( )Tj EMC (\023\024\f\035\036)Tj 0 Tw (-)Tj 0.546 Tw T* [(\024\023\036\030\026\006\017\024\027\027\024\n )0.6(\023\036\030\017\024\007\036 )0.5(\022\024\027\021\030\024\035\034 )0.6(\b\017\030\031\030\020\017\004\036\f\022\024\020\024 )]TJ 0.092 Tw T* (\f\021\026\021\031\f\026 \024\f\031\013\036\f\021\r\035\016\035\f\016 \r\ \017\031\026\035\034\027\024 \017)Tj /Span<>> BDC ( )Tj EMC (\f \023\024\n\024\013\034\033 \204\217\230. )Tj 0.387 Tw T* (\202\027\021\017\002\026\022\021\036\030\017\026\035\034\027\026\016 \021\ \036\030\026\023\017\016 \002\t\035\026 \027\026\004\026\021\026 \007\024\ )Tj /Span<>> BDC ( )Tj EMC (\024\023\036)Tj 0 Tw (-)Tj 0.22 Tw T* (\030\026\006\017\017 \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\007\024\035\032\036\027\026 \r)Tj /Span<>> BDC ( )Tj EMC (\023\024\f\035\036\024\023\036\030\026\006\017\024\027\027\024\n \023\036\ \030\017\024)Tj 0 Tw (-)Tj 0.212 Tw T* (\007\036 \007\024)Tj /Span<>> BDC ( )Tj EMC 2.846 0 Td [(\027\024\030\n\024\021\036\030\n\017\017 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC [(\030\036\020\030\036\f\f\026 )0.5(\n\036\f\021\027\t\b )0.5(\023\030\017\027\026\022\024\r )]TJ 0.559 Tw -2.846 -1.218 Td (\r\024\f\023\026\035\036\027\017\016. \212\035\016 \f\021\026\030\021\024\ \r\024\005 \220\n\023\017\030\017\004\036\f\022\024\005 \026\027\021\017\ )Tj 0 Tw (-)Tj 0.274 Tw T* (\002\026\022\021\036\030\017\026\035\034\027\024\005 \021\036\030\026\023\ \017\017 \017\f\023\024\035\034\024\r\026\035\017 \256-\035\026\022\021\ \026\n\027\t\036 )Tj 0.329 Tw T* (\026\027\021\017\002\017\024\021\017\022\017 \f)Tj /Span<>> BDC ( )Tj EMC (\017\027\020\017\002\017\021\024\030\026\n\017 \256-\035\026\022\021\026\ \n\026 \(\023\017\023\036\030\026)Tj 0 Tw (-)Tj 0.553 Tw T* (\006\017\035\035\017\027/\021\026\024\002\026\022\021\026\n \017\035\017\ \006\036\235\024\023\036\030\026\024\027/\f\031\035\034\002\026\022\021\ \026\n\) )Tj 0.461 Tw T* (\017\035\017 \022\026\030\002\026\023\036\027\036\n \f)Tj /Span<>> BDC ( )Tj EMC (\026\027\021\017\023\f\036\r\007\024\n\024\027\026\007\027\024\005 \026\022\ \021\017\r\027\024)Tj 0 Tw (-)Tj 0.203 Tw T* [(\f\021\034\033 )0.5(\(\017\n\017\023\036\027\036\n/\006\017\035\026\f\021\017\027, )0.7(\n\036\030\024\023\036\027\036\n, )0.5(\007\024\030\017\023\036\027\036\n\). )]TJ 0.052 Tw T* (\204\024\007\017\235\017\022\026\006\017\033 \026\027\021\017\002\026\022\ \021\036\030\017\026\035\034\027\024\005 \021\036\030\026\023\017\017 \023\ \030\024\r\024\007\017)Tj 0 Tw (-)Tj 0.014 Tw T* (\035\017 \f\024\020\035\026\f\027\024 \030\036\031\035\034\021\026\021\026\ \n \n\017\022\030\024\002\017\024\035\024\020\017\004\036\f\022\017\b \017\ \f\f\035\036)Tj 0 Tw (-)Tj 0.198 Tw T* (\007\024\r\026\027\017\005. \222\027\021\030\026\024\023\036\030\026\006\ \017\024\027\027\024 \017)Tj /Span<>> BDC ( )Tj EMC (\r \030\026\027\027\036\n \023\024\f\035\036\024\023\036)Tj 0 Tw (-)Tj 0.082 Tw T* (\030\026\006\017\024\027\027\024\n \023\036\030\017\024\007\036 \017\f\023\ \024\035\034\024\r\026\035\017 \020\017\007\030\024\017\n\023\031\035\034\ \f\027\031\033 )Tj 0.091 Tw T* (\f\026\027\026\006\017\033 \030\026\027\036\r\024\005 \023\024\r\036\030\ \b\027\024\f\021\017. \215\030\017)Tj /Span<>> BDC ( )Tj EMC (\r\t\023\024\035\027\036\027\017\017 \020\017)Tj 0 Tw (-)Tj 0.104 Tw T* (\007\030\024\017\n\023\031\035\034\f\027\024\005 \f\026\027\026\006\017\017\ \017\f\023\024\035\034\024\r\026\035\017 0,9% \030\026\f\021\r\024\030\ )Tj 0.054 Tw T* (NaCl, 0,2% \030\026\f\021\r\024\030 \b\035\024\030\020\036\022\f\017\007\ \017\027\026. \212\026\r\035\036\027\017\036 \r)Tj /Span<>> BDC ( )Tj EMC (\030\026\002\024)Tj 0 Tw (-)Tj 0.11 Tw T* (\004\036\n \022\024\027\021\031\030\036 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\r\036\007\036\027\017\017 \023\030\024\006\036\007\031\030\t\ \f\024\f\021\026\r\035\016\035\024 )Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 0 Tw 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\033\030\031\030\213\b)-20.9(\035\231\213\233\t \021\032)50(\b)42(\032\231\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj /T1_3 1 Tf 25 0 0 25 504.6646 56.0378 Tm (119)Tj ET endstream endobj 1215 0 obj <>stream q /GS0 gs /Fm0 Do Q 0 0 0 1 K 1 j 1 J [0 2.997]0 d /GS1 gs q 1 0 0 1 74.3631 480.8534 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 71.3661 480.8534 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q [0 2.997]0 d q 1 0 0 1 74.3631 443.6456 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 71.3661 443.6456 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q 0 j 0 J q 1 0 0 1 70.8661 389.5764 cm 0 0 m 453.543 0 l S Q BT 0 0 0 1 k /T1_0 1 Tf 0.131 Tw 9 0 0 9 119.0551 730.4919 Tm [(AIM: to w)12(ork out an algor)-36.9(ithm for diagnosis and tactics of treatment of com)16(plicated per)-37(ianal abscess \(CP)45(A\) in )]TJ 0 Tw 0 -1.111 TD [(oncohematology)32.1(.)]TJ -0.032 Tw T* [(P)45(A)45(TIENT)-9.9(S A)53(ND METHODS: the cohor)-40(t study \(Januar)-42.9(y 2021)]TJ /Span<>> BDC ( )Tj EMC (\227 December 2022\) included 78 patients with hematologic )Tj 0.004 Tw T* [(malignancies )0.6(and )0.5(infectious )0.6(lesions )0.5(of )0.5(the )0.5(per)-37(ianal )0.6(sof)-46(t )0.5(tissues. )0.5(Com)16.1(ple)-15(x )0.5(per)-37(ianal infection )0.5(\(CPI\) )0.5(w)13(as )0.5(distinguished )]TJ -0.015 Tw T* [(in the p)46(resence of sup)46(ralev)16(ator abscess, pelvic phlegmon, destruction of the rectal w)13(all abov)12.9(e the lev)13(el of the dentate )]TJ 0.044 Tw 0 -1.111 TD [(line, and pelvic org)12.1(ans in)11(v)13(olv)13(ement. The cor)-16(respondence of clinical, laborator)-43(y d)26(ata and MRI results, as w)12(ell as the )]TJ 0.023 Tw 0 -1.111 TD [(results of surgical drainag)12(e, antibacter)-36.9(ial therap)12(y)42(, and v)16(acuum therap)12.1(y w)12(ere assessed.)]TJ 0.144 Tw T* [(RESUL)30(T)-10(S: CPI w)13(as detected in 7 \(8.97%\) patients with per)-36.9(ianal infection. The neutropenia w)13(as detected in all )]TJ -0.004 Tw T* (patients \(neutrophils)Tj /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (500)Tj /Span<>> BDC ( )Tj EMC (\327)Tj /Span<>> BDC ( )Tj EMC (10)Tj 0 Tw 5.247 0 0 5.247 233.3448 653.4889 Tm (9)Tj -0.004 Tw 9 0 0 9 235.9683 650.4919 Tm [(/l\); no fev)13.1(er occur)-16(red in tw)12(o patients. Clinical d)26(ata w)12(ere adjusted af)-46(ter MRI results )]TJ 0.016 Tw -12.99 -1.111 Td [(in 6 \(85.7%\) cases. P)15(elviorectal abscesses w)12(ere no)13(ted in 5 patients, in 2)]TJ /Span<>> BDC ( )Tj EMC [(\227 pelvic phlegmon w)13(as detected. In addi)]TJ 0 Tw (-)Tj 0.039 Tw T* [(tion, 2 patients rev)13(ealed per)-34(foration of the rectum abov)13(e the dentate line, 1)]TJ /Span<>> BDC ( )Tj EMC [(\227 rectov)16(aginal f)-43(istula. Due to sepsis, )]TJ 0.056 Tw T* [(4 \(57.14%\) patients w)12(ere in the intensiv)13(e care unit, the per)-37(iod in the intensiv)13(e care unit w)13(as 32.5 \(17\22654\) d)26(ays. )]TJ 0.083 Tw T* [(A)12(bscess drainag)12.1(e w)13(as per)-34(for)-14(med in all patients, in 3 cases)]TJ /Span<>> BDC ( )Tj EMC [(\227 div)13(er)-40(ting sigmostom)11(y)32(. The w)12(ound repair phase w)13(as )]TJ 0.071 Tw 0 -1.111 TD [(achiev)13(ed in all patients. The time of reparation w)13(as 79 \(37\226142\) d)26(ays. V)32.9(acuum therap)12(y w)13(as used in 2 cases with )]TJ -0.032 Tw 0 -1.111 TD [(w)12(ound repair time of 53.5 d)26(ays. P)14.9(ostoperativ)13(ely)42(, febr)-36.9(ile fev)13(er with per)-37(iods of nor)-14(mo)13(ther)-14(mia for 1 month w)13(as rev)13(ealed )]TJ 0.023 Tw T* [(in all cases. T)52(w)12(o patients died within 50 and 215 d)26(ays from causes unrelated to per)-36.9(ianal abscess.)]TJ 0.096 Tw T* [(C)21(ON)22(CLUSION: pelvic MRI is a p)46(referable diagnostic test to deter)-14(mine the v)13(olume of lesion in CPI in patients with )]TJ 0.119 Tw T* (hematological malignancies. CPI in patients with neutropenia is associat\ ed with a high incidence of sepsis. The )Tj 0.064 Tw T* [(main )0.5(methods )0.5(of )0.5(infection )0.5(control )0.5(are )0.5(abscess )0.5(drainag)12(e )0.5(and )0.5(antibacter)-36.9(ial )0.5(therap)12(y)42(, which should be )0.5(star)-40(ted before )]TJ 0.079 Tw T* [(surg)12(er)-43(y and continued in the postoperativ)13.1(e per)-36.9(iod until nor)-14(mo)13(ther)-14(mia and reg)14(ression of local signs of inf)-22(lamma)]TJ 0 Tw (-)Tj 0.125 Tw T* [(tion. )0.5(V)33(acuum )0.5(therap)12.1(y is )0.5(a )0.5(safe )0.5(and )0.5(ef)-40(fectiv)13(e )0.5(method )0.6(in treatment )0.6(of )0.5(big )0.5(postoperativ)12.9(e )0.5(w)12(ounds )0.5(in )0.5(patients )0.5(with )]TJ 0 Tw T* (neutropenia.)Tj /T1_1 1 Tf 0.01 Tc -0.01 Tw 8 0 0 8 70.9061 505.2226 Tm [(KEYW)22(ORDS:)]TJ /T1_0 1 Tf 0 Tc 0.023 Tw 4.948 0 Td [( per)-37(ianal abscess, per)-37(ianal infection, abscess, leuk)17.1(emia, neutropenia, hemoblastosis)]TJ /T1_1 1 Tf 0.01 Tc 0.018 Tw -4.948 -1.909 Td [(C)19(ONFL)-33(ICT)5( OF)5( INTE)25(REST)62(:)]TJ /T1_0 1 Tf 0 Tc 0.023 Tw 9.871 0 Td [( The authors declare no conf)-22(lict of interest)]TJ /T1_1 1 Tf 0.036 Tc -0.044 Tw -9.871 -2.617 Td [(F)3.3(O)-4.6(R)8.8( C)-17.5(I)-15.5(T)45.4(A)37.6(T)-24.4(I)-1.3(ON:)]TJ /T1_2 1 Tf 0.022 Tc -0.035 Tw 6.387 0 Td [( S)-10.2(h)-17.2(t)-50.8(y)-32.2(r)-30.7(k)-3.6(o)-10.3(v)-28.3(a)]TJ /Span<>> BDC ( )Tj EMC [(S)-9.5(.)40.7(V)39.7(.)-23.4(, S)-25.1(o)-11.5(b)-20.4(o)-15.5(l)-23.7(e)-15.7(v)-28.4(a)]TJ /Span<>> BDC ( )Tj EMC [(O)11.5(.)-23.9(A)-22.9(.)-23.4(, S)-27(a)-18.2(b)-19.4(i)-6(r)-15.7(o)-10.3(v)]TJ /Span<>> BDC ( )Tj EMC [(K)-26.9(.R)-21.3(.)-23.4(, N)-10.3(o)-10.2(v)-51.8(i)-6.5(k)-3.7(o)-10.2(v)]TJ /Span<>> BDC ( )Tj EMC [(V)39.7(.)-23.8(A)-23(.)-23.4(, N)-16.8(t)-36.7(a)-7.6(n)-13.9(i)-7.3(s)-8.8(h)-14.8(y)-24.2(a)-7.5(n)]TJ /Span<>> BDC ( )Tj EMC [(K)-27(.)-9.7(I)-10.3(.)-23.4(, P)-10.3(a)-10.1(r)-15.8(o)-10.2(v)-51.7(i)-5(c)-10.1(h)-4.9(n)-13.9(i)-6.6(k)-3.6(o)-10.2(v)-28.4(a)]TJ /Span<>> BDC ( )Tj EMC [(E)-5.5(.)-1.9(N)-2.7(. D)-30.2(i)-5(a)-10.8(g)-8.7(n)-11.9(o)-15.7(s)-29.3(t)-46.1(i)-4.9(c)-32.2(s a)-7.6(n)-14.4(d t)-30.7(r)-19(e)-13(a)-18.1(t)]TJ 0 Tc 0 Tw 49.949 0 Td (-)Tj 0.023 Tc 0.005 Tw -56.341 -1.2 Td [(m)-16.6(e)-11.5(n)-17.3(t o)-12.1(f c)-6.5(o)-9.2(m)-5.2(p)-20.1(l)-16.7(i)-5(c)-21.5(a)-18.2(t)-24.7(e)-20.9(d p)-24.7(e)-12.1(r)-56.4(i)-5.1(a)-7.6(n)-7.8(a)-11.4(l a)-18.2(b)-17.7(s)-17.7(c)-9.7(e)-22.8(s)-22.3(s i)-3.3(n p)-20(a)-18.2(t)-46.2(i)-11(e)-11.5(n)-17.3(t)-48.9(s w)-45.7(i)-15.8(t)-26.1(h h)-15.1(e)-11.5(m)-8.3(a)-18.2(t)-21.9(o)-15.6(l)-20.9(o)-18.6(g)-28.9(i)-5(c m)-8.3(a)-11.4(l)-16.7(i)-6.8(g)-8.7(n)-7.9(a)-7.6(n)-9.9(c)-38.3(i)-11(e)-22.7(s)-15.5(. )]TJ /T1_0 1 Tf 0.033 Tc -0.033 Tw [(K)13.9(ol)3.7(op)2.4(r)3.1(o)3.4(k)-19.2(t)2.3(ol)3.6(o)-3.3(g)-13.2(i)6.8(a)5.8(.)]TJ /T1_2 1 Tf 0.013 Tc 0.015 Tw 42.851 0 Td [( 2)-19(0)-13.7(2)-1.2(4;2)-20.3(3)-4(\()27.7(1)34.3(\))4.5(:)10.9(1)19.8(1)14.2(7)25.7(\226)40.8(1)-10(2)-15.2(8)-21.1(.)-10.3( \()-10.9(i)-13.2(n)-10.3( R)-16.5(u)-31.9(s)-32.3(s)-25.5(.)33.2(\).)13( )]TJ 0.023 Tc -0.023 Tw -42.851 -1.2 Td [(h)-17.2(t)-49.4(t)-29.4(p)-18.7(s)-8(:)1.9(/)84.7(/)36.4(d)-11.1(o)-12.5(i.)2.7(o)-11.8(r)-16.7(g)-22.8(/)11.2(1)14(0)6.5(.)-5.6(3)7.9(3)-15.9(8)1.3(7)4.6(8/)7.9(2)-8.9(0)9.3(7)-1.9(3)-13.3(-)41.2(7)10.7(55)-8.9(6)-26.7(-)9.7(2)-8.9(0)-3.8(2)8.8(4)-28.5(-)9.7(2)-10.3(3)-13.3(-)55.1(1)26.9(-)55.1(1)29.8(1)24.2(7)36.2(-)55.1(12)-5.2(8)]TJ /T1_1 1 Tf 0.01 Tc 0.027 Tw 0.005 -2.617 Td [(\026\020\021\033\030)5( )0.6(\020\036\017)5( )0.5(\013\033\021\033\013\023\030\037\023:)]TJ /T1_0 1 Tf 0 Tc 0.032 Tw 10.594 0 Td [( )0.5(\231\024\020\032\013\n\027\026 )0.7(\207\027\031\024\023\026\021\026 )0.6(\216\025\024\026\023\022\031\027\021\026, )0.6(\225\210\213\214 )0.5(\253\217\240\215\037 )0.6(\202\031\003\026\024\n\023\n\202\025\025\273 )0.6(\240\025\021\016\030\032\026\027\026 )0.6(\212\n\t\t\025\025, )0.6(\217\n\027\020\017 )0.6(\221\020\013\n\027\t\013\025\017 )0.7(\033\032-\030, )0.5(\030.)]TJ /Span<>> BDC ( )Tj EMC 45.39 0 Td (4, )Tj 0.023 Tw -55.989 -1.2 Td (\240\n\t\013\027\026, 125167, \212\n\t\t\025\002; \024\031\023. \003\n\005\ .:)Tj /Span<>> BDC ( )Tj EMC (+7 \(916\) 136-04-21, \024\031\023. \032\026\005.:)Tj /Span<>> BDC ( )Tj EMC (+7)Tj /Span<>> BDC ( )Tj EMC (\(495\) 612-61-91; e-mail: sv-styrkova@mail.ru)Tj /T1_1 1 Tf 0.01 Tc -0.06 Tw 0.005 -1.2 Td [(ADDRESS)5( F)13(OR)5( C)19.1(ORRESPONDEN)23(CE:)]TJ /T1_0 1 Tf 0 Tc -0.055 Tw 13.894 0 Td [( Shtyrk)13.1(ov)16(a Sv)12.9(etlana )0.5(V)61(. 125167, N)18(ational R)21(esearch Center for Hematology)42.1(, N)28(.Zyk)13(ovsky p)46(roezd, 4, Moscow)52(,125167; )]TJ 0.023 Tw -13.899 -1.2 Td [(R)22(ussia; tel.:)]TJ /Span<>> BDC ( )Tj EMC [(+7 \(916\) 136-04-21; e-mail: sv-styrk)13(ov)16(a@mail.ru)]TJ 0 Tw 0 -2.792 TD (\200\026\024\026 \033\n\t\024\205\033\023\031\021\025\002)Tj /Span<>> BDC ( )Tj EMC (\227 23.08.2023)Tj /Span<>> BDC ( )Tj EMC 19.488 0 Td (\n\t\023\031 \030\n\032\026\005\n\024\013\025)Tj /Span<>> BDC ( )Tj EMC (\227 22.12.2023)Tj /Span<>> BDC ( )Tj EMC 18.78 0 Td (\032\025\021\002\024\n \013)Tj /Span<>> BDC ( )Tj EMC (\033\205\005\023\025\013\026\203\025\025)Tj /Span<>> BDC ( )Tj EMC (\227 12.02.2024)Tj ( )Tj -38.268 -1.375 Td (Received)Tj /Span<>> BDC ( )Tj EMC (\227 23.08.2023)Tj /Span<>> BDC ( )Tj EMC 19.488 0 Td (Revised)Tj /Span<>> BDC ( )Tj EMC (\227 22.12.2023)Tj /Span<>> BDC ( )Tj EMC 18.78 0 Td (Accepted for publication)Tj /Span<>> BDC ( )Tj EMC (\227 12.02.2024)Tj /T1_3 1 Tf 0.023 Tw 10 0 0 10 70.8661 335.1339 Tm (\255\200\034\255\017\021 \255\017\021\022\032\233\036\025\034\023)Tj /T1_2 1 Tf -0.021 Tw 0 -1.218 TD (\202\035\035\024-\230\206\221\025)Tj /Span<>> BDC ( )Tj EMC (\227 \202\035\035\024\020\036\027\027\026\016 \021\030\026\027\f\023\035\ \026\027\021\026\006\017\016 \020\036\n\024\023\024\220\021\017)Tj 0 Tw (-)Tj T* (\004\036\f\022\017\b \f\021\r\024\035\024\r\t\b \022\035\036\021\024\022\ ;)Tj 0.02 Tw T* (\202\031\021\024-\230\206\221\025)Tj /Span<>> BDC ( )Tj EMC [(\227 \202\031\021\024\035\024\020\017\004\027\026\016 )0.5(\021\030\026\027\f\023\035\026\027\021\026\006\017\016 \020\036\n\024\023\ \024\220)]TJ 0 Tw (-)Tj T* (\021\017\004\036\f\022\017\b \f\021\r\024\035\024\r\t\b \022\035\036\021\ \024\022;)Tj T* (\206\025\221)Tj /Span<>> BDC ( )Tj EMC (\227 \020\035\033\022\024\022\024\030\021\017\022\024\f\021\036\030\024\017\ \007\t;)Tj T* (\204\217\230)Tj /Span<>> BDC ( )Tj EMC (\227 \n\026\020\027\017\021\027\024-\030\036\024\027\026\027\f\027\026\016\ \021\024\n\024\020\030\026\235\017\016;)Tj T* (\210\204\214)Tj /Span<>> BDC ( )Tj EMC (\227 \024\f\021\030\t\005 \n\017\036\035\024\017\007\027\t\005 \035\036\005\ \022\024;)Tj T* (\210\214\214)Tj /Span<>> BDC ( )Tj EMC (\227 \024\f\021\030\t\005 \035\017\n\235\024\002\035\026\f\021\027\t\005\ \035\036\005\022\024;)Tj 0.711 Tw T* (\210\217\222\230)Tj /Span<>> BDC ( )Tj EMC (\227 \024\021\007\036\035\036\027\017\036 \030\036\026\027\017\n\026\006\ \017\017 \017\017\027\021\036\027\f\017\r\027\024\005 )Tj 0 Tw T* (\021\036\030\026\023\017\017;)Tj T* (\215\222)Tj /Span<>> BDC ( )Tj EMC (\227 \023\036\030\017\026\027\026\035\034\027\026\016 \017\027\235\036\022\ \006\017\016;)Tj T* (\221\205\215)Tj /Span<>> BDC ( )Tj EMC (\227 \f\035\024\032\027\t\036 \235\024\030\n\t \023\026\030\026\023\030\024\ \022\021\017\021\026;)Tj T* (\216\230)Tj /Span<>> BDC ( )Tj EMC (\227 \b\017\n\017\024\021\036\030\026\023\017\016.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 70.936 140.2859 Tm (\023\023\034\226\034\022\031\034)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf 0 Tc 0.051 Tw 10 0 0 10 70.8661 115.9299 Tm [(\222\027\235\036\022\006\017\016 )0.6(\n\016\020\022\017\b )0.5(\021\022\026\027\036\005 )0.5(\023\036\030\017\026\027\026\035\034\027\024\005 )0.6(\024\002\035\026\f\021\017 )0.5(\(\007\026)]TJ 0 Tw (-)Tj -0.03 Tw T* (\035\036\036)Tj /Span<>> BDC ( )Tj EMC [(\227 \023\036\030\017\026\027\026\035\034\027\026\016 )0.5(\017\027\235\036\022\006\017\016\) )0.5(\r\f\021\030\036\004\026\036\021\f\016 \031)]TJ /Span<>> BDC ( )Tj EMC 19.295 0 Td (7\22611% )Tj 0 Tw -19.295 -1.218 Td (\024\027\022\024\020\036\n\026\021\024\035\024\020\017\004\036\f\022\017\ \b \002\024\035\034\027\t\b [1\2265].)Tj 0.27 Tw 23.244 24.356 Td (\215\036\030\017\026\027\026\035\034\027\026\016 \017\027\235\036\022\006\ \017\016 \(\215\222\) \031)Tj /Span<>> BDC ( )Tj EMC (\007\026\027\027\024\005 \022\026\021\036\020\024\030\017\017 )Tj 0.502 Tw T* [(\023\026\006\017\036\027\021\024\r )0.5(\024\021\035\017\004\026\036\021\f\016 )0.6(\r\026\030\017\026\002\036\035\034\027\024\f\021\034\033 )0.6(\022\035\017\027\017\004\036)]TJ 0 Tw (-)Tj -0.023 Tw T* [(\f\022\017\b \023\030\024\016\r\035\036\027\017\005. )0.5(\215\024\n\017\n\024 \023\026\030\026\030\036\022\021\026\035\034\027\t\b\ )0.5(\026\002\f\006\036\f\f\024\r )]TJ -0.024 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\f\r\017\013\036\005 \022)Tj /Span<>> BDC ( )Tj EMC (\215\222 \024\021\027\024\f\016\021 \r\024\f\023\026\035\017\021\036\035\ \034\027\t\036 \017\027\235\017\035\034\021\030\026\021\t, )Tj 0.046 Tw T* (\027\036\022\030\024\t \022\024\032\017 \026\027\026\035\034\027\024\020\ \024 \022\026\027\026\035\026 \017)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\017\026\027\026\035\034\027\024\005 \024\002)Tj 0 Tw (-)Tj 0.108 Tw T* [(\035\026\f\021\017, )0.5(\023\024\030\026\032\036\027\017\036 )0.6(\n\016\020\022\017\b )0.5(\021\022\026\027\036\005 )0.5(\r\f\035\036\007\f\021\r\017\036 )0.5(\020\036\n\026\021\024)]TJ 0 Tw (-)Tj 0.013 Tw T* [(\020\036\027\027\024\020\024 )0.5(\030\026\f\023\030\024\f\021\030\026\027\036\027\017\016 )0.5(\017\027\235\036\022\006\017\017 \017)]TJ /Span<>> BDC ( )Tj EMC 16.062 0 Td [(\007\030. [1,6]. )0.5(\212\024\035\016 )]TJ 0.018 Tw -16.062 -1.218 Td (\023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\215\222, \021\030\036\002\031\033\013\017\b \b\017\030\031\030\020\017\004\ \036\f\022\024\020\024 \035\036\004\036\027\017\016, )Tj -0.003 Tw T* (\f\024\f\021\026\r\035\016\036\021 22,1% [6]. \203\026\017\002\024\035\036\ \036 \021\016\032\036\035\024\005 \023\030\036\007\f\021\026\r\035\016)Tj 0 Tw (-)Tj 0.093 Tw T* (\036\021\f\016 \020\030\031\023\023\026 \023\026\006\017\036\027\021\024\ \r \f\024 \f\035\024\032\027\t\n\017 \235\024\030\n\026\n\017 \023\026\030\ \026)Tj 0 Tw (-)Tj 0.083 Tw T* (\023\030\024\022\021\017\021\026 \(\221\205\215\), \023\024\030\026\032\036\ \027\017\036\n \020\035\031\002\024\022\017\b \022\035\036\021\004\026\021\ \024\004\027\t\b )Tj 0.038 Tw T* (\023\030\024\f\021\030\026\027\f\021\r \017)Tj /Span<>> BDC ( )Tj EMC (\024\030\020\026\027\024\r \n\026\035\024\020\024 \021\026\026 [7]. \217\ \026\r\017\021\017\036 \017\027)Tj 0 Tw (-)Tj -0.019 Tw T* (\235\036\022\006\017\017 \031)Tj /Span<>> BDC ( )Tj EMC (\024\027\022\024\020\036\n\026\021\024\035\024\020\017\004\036\f\022\017\ \b \002\024\035\034\027\t\b \023\030\024\017\f\b\024\007\017\021 )Tj 0.206 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC (\235\024\027\036 \026\022\021\017\r\027\024\020\024 \024\023\031\b\024\035\ \036\r\024\020\024 \023\030\024\006\036\f\f\026, \023\024\030\026\032\036\ )Tj 0 Tw (-)Tj 0.15 Tw T* (\027\017\016 \f\017\f\021\036\n\t \022\030\024\r\036\021\r\024\030\036\027\ \017\016, \027\026\030\031\001\036\027\017\005 \022\035\036\021\024\004\027\ \024\020\024 )Tj 0.14 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC [(\020\031\n\024\030\026\035\034\027\024\020\024 \017\n\n\031\027\017\021\036\ \021\026, )0.5(\021\036\030\026\023\017\017 \006\017\021\024\f\021\026\021\017\022\026\n\ \017 )]TJ 0.236 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\020\035\033\022\024\022\024\030\021\017\022\024\f\021\036\030\024\017\007\ \026\n\017 \(\206\025\221\). \200)Tj /Span<>> BDC ( )Tj EMC (\220\021\017\b \031\f\035\024\r\017\016\b )Tj 0.262 Tw T* [(\n\036\f\021\027\t\036 )0.5(\023\030\024\016\r\035\036\027\017\016 )0.6(\017\027\235\036\022\006\017\017 )0.6(\n\024\020\031\021 )0.5(\002\t\021\034 )0.5(\022\030\026\005\027\036 )]TJ 0.226 Tw T* (\f\022\031\007\027\t\n\017 \017\035\017 \024\021\f\031\021\f\021\r\024\r\ \026\021\034 [1,6], \026)Tj /Span<>> BDC ( )Tj EMC (\021\030\026\007\017\006\017\024\027\027\t\036 )Tj 0.227 Tw T* (\022\035\017\027\017\004\036\f\022\017\036 \024\030\017\036\027\021\017\030\ \t \021\026\022\017\036 \022\026\022 \035\017\b\024\030\026\007\022\026,\ \035\036\005)Tj 0 Tw (-)Tj 0.408 Tw T* (\022\024\006\017\021\024, \026\022\021\017\r\027\024\f\021\034 \023\030\ \024\r\024\f\023\026\035\017\021\036\035\034\027\t\b \n\026\030\022\036\030\ \024\r )Tj 0.4 Tw T* (\021\036\030\016\033\021 \007\017\026\020\027\024\f\021\017\004\036\f\022\ \031\033 \006\036\027\027\024\f\021\034. \216\017\030\031\030\020\017\004\ \036\f\022\024\036 )Tj ET 1 0.68 0 0.12 k /GS0 gs q 1 0 0 1 70.8661 738.9961 cm 0 0 m 0 0 l 0 -11.339 l 42.52 -11.339 l 42.52 0 l h f Q BT 0 0 0 0 k /T1_1 1 Tf 0 Tw 9 0 0 9 73.5728 730.0688 Tm (ABSTRACT)Tj 1 0.68 0 0.12 k /T1_5 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\033\030\031\030\213\b)-20.9(\035\231\213\233\t \021\032)50(\b)42(\032\231\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj -51.938 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 23, \023\0221)69(, 202)69(4)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 23, \023\0221)69(, 202)69(4)]TJ /T1_6 1 Tf 25 0 0 25 19.9527 56.0378 Tm (118)Tj ET endstream endobj 1212 0 obj [1218 0 R] endobj 1213 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\255\220\013\202\001\025\006)-9.9(\026\220\n\013 \220\022\007\016\017\016\001\220\016 \006)-10(\007\025\217\001\020\207 \225\025\002\024 \025\006)-10(\026\002\025\202)10(\025 \221\013\002\013\221\002\025\n)-10(\026\220\026)11(\013 )]TJ 0 -1 TD [(\215\022\221\013\227\220\016\001\026)11.1(\025\r \006\022\025\221\215)21(\207\025\007\016\r\020\024\220 \222\013\f\025\007\016\r\013\001\220\205\024\ \220 \006\220\006)-10(\026)11(\016\024\020 \n\002\025\r\220)]TJ 40.547 1 Td [(Diagnostics and tr)31(eatment of complicated perianal )]TJ 0.208 -1 Td [(abscess in patients with h)11(ematologic malignancies)]TJ ET 0 0 0 1 K 1 j 1 J [0 2.997]0 d /GS1 gs q 1 0 0 1 46.0167 231.741 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 43.0197 231.741 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q [0 2.997]0 d q 1 0 0 1 46.0167 194.5332 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 43.0197 194.5332 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q BT 0 0 0 1 k /T1_1 1 Tf 10 0 0 10 42.5197 724.8299 Tm (https://doi.org/10.33878/2073-7556-2024-23-1-117-128)Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 0.023 Tw 19 0 0 19 82.7382 695.3259 Tm [(\255\220\013\202\001\025\006)-9.9(\026\220\n\013 \220\022)-23.3(\007\016\017\016\001\220\016 \006)-10(\007\025\217\001\020\207 \225\025\002\024 \025\006)-10(\026\002\025\202)10(\025 )]TJ 0.99 -1.105 Td [(\221\013\002\013\221\002\025\n)-10(\026\220\026)11.1(\013 \215\022)-23.3(\221\013\227\220\016\001\026)11(\025\r \006\022)-23.2(\025\221\215)21(\207\025\007\016\r\020\024\220 )]TJ 2.437 -1.105 Td [(\222\013\f\025\007\016\r\013\001\220\205\024\220 \006\220\006)-10(\026)11(\016\024\020 \n\002\025\r\220)]TJ 0 0 0 1 k /GS1 gs 14 0 0 14 42.5197 628.822 Tm [(\206\026\020\002\n)10.1(\025\r\013\022)-23.3(\021.\004., \021\025\f\025\007\016\r\013\022)-23.2(\036.\b)-31(., \021\013\f\220\002\025\r\022)-23.2(\037.\033)124(., \213\025\r\220\n)10(\025\r\022)-23.3(\004.\b)-30.9(., \255\013\001\220\205\001\022)-23.2(\037.\030., )]TJ 0 Tw 0 -1.143 TD [(\034\013\002\025\r\220\017\001\220\n)10.1(\025\r\013\022)-23.3(\t.\213.)]TJ 0.023 Tw 10 0 0 10 42.5197 595.1527 Tm [(\210\031\214)42(\240 \253\213M\030\226 \202)10(\016\024\013\026)11(\025\007\025\202\220\220\273 \005\220\001\222\201\002\013\r\013 \033\025\ \006\006\220\220 \(\213\025\r\020\203 \211\020\n)10.1(\025\r\006\n\220\203 \221\002\025\016\222\201, \201.\022)-23.3(4, \202)62(.\022)-23.3(\005\025\006\n\r\013, 1)125(2)23(5)127(1)112(6)58(7)127(, \033\025\006\006\220\205\))]TJ /T1_1 1 Tf -0.008 Tw 9 0 0 9 90.7087 576.6487 Tm (\037\036\035\034 \215\207\207\035\036\200\255\216\201\217\215\243: \032\026\ \016\032\026\005\n\024\026\024\022 \026\023\202\n\032\025\024\003 \030\025\ \026\202\021\n\t\024\025\013\025 \025)Tj /Span<>> BDC ( )Tj EMC (\024\026\013\024\025\013\205 \023\031\006\031\021\025\002 \t\023\n\204\021\ \020\004 \f\n\032\003 \033\026\032\026\033\032\n\013\024\025)Tj 0 Tw (-)Tj 0.023 Tw 0 -1.111 TD (\024\026 \(\207\225\) \205)Tj /Span<>> BDC ( )Tj EMC (\n\021\013\n\202\031\003\026\024\n\023\n\202\025\006\031\t\013\025\004 \005\ \n\023\022\021\020\004)Tj 0.136 Tw T* (\201\037\215\036\217\220\235 \215)Tj /Span<>> BDC ( )Tj EMC (\240\036\220\255\200\235: \027)Tj /Span<>> BDC ( )Tj EMC [(\013\n\202\n\032\024\021\n\031 \025\t\t\023\031\030\n\027\026\021\025\031\ , )0.5(\027\020\033\n\023\021\031\021\021\n\031 \t)]TJ /Span<>> BDC ( )Tj EMC (\002\021\027\026\032\002 2021 \033\n)Tj /Span<>> BDC ( )Tj EMC (\030\031\013\026\005\032\022 2022 \202\202., \005\020\023\025 )Tj 0.002 Tw T* (\027\013\023\007\006\031\021\020 78 \033\026\203\025\031\021\024\n\027 \t\ )Tj /Span<>> BDC ( )Tj EMC (\202\031\003\n\005\023\026\t\024\n\016\026\003\025\025 \025\021\f\031\013\ \203\025\n\021\021\020\003 \033\n\032\026\204\031\021\025\031\003 \003\002\ \202\013\025\004 \024\013\026\021\031\017 \033\031\032\025\026\021\026\023\ \022\021\n\017 \n\005\023\026)Tj 0 Tw (-)Tj 0.112 Tw T* (\t\024\025. \207\225 \027\020\030\031\023\002\023\025 \033\032\025)Tj /Span<>> BDC ( )Tj EMC (\021\026\023\025\006\025\025 \t\205\033\032\026\023\031\027\026\024\n\032\ \021\n\202\n \026\005\t\203\031\t\t\026, \f\023\031\202\003\n\021\020 \024\ \026\016\026, \032\026\016\032\205\001\031\021\025\002 \t\024\031\021\013\ \025 \033\032\002\003\n\017 )Tj 0.09 Tw 0 -1.111 TD (\013\025\001\013\025 \027\020\001\031 \205\032\n\027\021\002 \016\205\005\ \006\026\024\n\017 \023\025\021\025\025, \033\n\032\026\204\031\021\025\002\ \024\026\016\n\027\020\004 \n\032\202\026\021\n\027. \255\203\031\021\025\ \027\026\023\025 \t\n\n\024\027\031\024\t\024\027\025\031 \013\023\025\021\ \025\006\031\t\013\025\004 )Tj 0.061 Tw 0 -1.111 TD (\025)Tj /Span<>> BDC ( )Tj EMC (\023\026\005\n\032\026\024\n\032\021\020\004 \030\026\021\021\020\004 \025\ )Tj /Span<>> BDC ( )Tj EMC (\032\031\016\205\023\022\024\026\024\n\027 \240\212\220, \026)Tj /Span<>> BDC ( )Tj EMC (\024\026\013\204\031 \032\031\016\205\023\022\024\026\024\020 \n\033\031\ \032\026\024\025\027\021\n\202\n \030\032\031\021\025\032\n\027\026\021\025\ \002, \026\021\024\025\005\026\013)Tj 0 Tw (-)Tj 0.023 Tw T* (\024\031\032\025\026\023\022\021\n\017 \024\031\032\026\033\025\025, \027\ \026\013\205\205\003-\024\031\032\026\033\025\025.)Tj -0.009 Tw T* [(\212\036\221\214\035\034\220\201\220\235: \207\225 \005\020\023\025 \027\ \020\002\027\023\031\021\020 )0.5(\205)]TJ /Span<>> BDC ( )Tj EMC (7)Tj /Span<>> BDC ( )Tj EMC (\(8,97%\) \025\016)Tj /Span<>> BDC ( )Tj EMC (78 \033\026\203\025\031\021\024\n\027 \t)Tj /Span<>> BDC ( )Tj EMC (\033\031\032\025\026\021\026\023\022\021\n\017 \025\021\f\031\013\203\025\ \031\017. \032\025)Tj /Span<>> BDC ( )Tj EMC (\030\025\026\202\021\n\t\024\025\013\031 )Tj 0.007 Tw T* (\207\225 \205)Tj /Span<>> BDC ( )Tj EMC (\027\t\031\004 \033\026\203\025\031\021\024\n\027 \005\020\023\026 \027\020\ \002\027\023\031\021\026 \021\031\017\024\032\n\033\031\021\025\002 \(\021\ \031\017\024\032\n\f\025\023\020)Tj /Span<>> BDC ( )Tj EMC (\244)Tj /Span<>> BDC ( )Tj EMC (500)Tj /Span<>> BDC ( )Tj EMC (\327)Tj /Span<>> BDC ( )Tj EMC (10)Tj 0 Tw 5.247 0 0 5.247 377.7673 489.6458 Tm (9)Tj 0.007 Tw 9 0 0 9 380.3908 486.6487 Tm (/\023\); \205)Tj /Span<>> BDC ( )Tj EMC (\030\027\205\004 \033\026\203\025\031\021\024\n\027 \n\024\003\031\006\031\ )Tj 0 Tw (-)Tj 0.059 Tw -32.187 -1.111 Td (\021\n \n\024\t\205\024\t\024\027\025\031 \023\025\004\n\032\026\030\013\ \025. \200\026\021\021\020\031 \013\023\025\021\025\006\031\t\013\n\202\n\ \n\t\003\n\024\032\026 \005\020\023\025 \t\013\n\032\032\031\013\024\025\ \032\n\027\026\021\020 \033\n\t\023\031 \032\031\016\205\023\022\024\026\ \024\n\027 \240\212\220 )Tj -0.004 Tw T* (\027)Tj /Span<>> BDC ( )Tj EMC (6)Tj /Span<>> BDC ( )Tj EMC (\(85,7%\) \025\016)Tj /Span<>> BDC ( )Tj EMC (7 \t\023\205\006\026\031\027. \225\n\032\003\025\032\n\027\026\021\025\031\ \033\031\023\022\027\025\n\032\031\013\024\026\023\022\021\020\004 \026\ \005\t\203\031\t\t\n\027 \005\020\023\n \n\024\003\031\006\031\021\n \205\ )Tj /Span<>> BDC ( )Tj EMC (5 \033\026\203\025\031\021\024\n\027, \205)Tj /Span<>> BDC ( )Tj EMC (2)Tj /Span<>> BDC ( )Tj EMC (\227 )Tj 0.21 Tw T* (\033\n\032\026\204\031\021\025\031 \033\031\023\022\027\025\n\032\031\013\ \024\026\023\022\021\n\017 \013\023\031\024\006\026\024\013\025 \005\020\ \023\n \033\032\031\030\t\024\026\027\023\031\021\n \f\023\031\202\003\n\ \021\n\017. \222\032\n\003\031 \024\n\202\n, \205)Tj /Span<>> BDC ( )Tj EMC (2 \033\026\203\025\031\021\024\n\027 )Tj 0.006 Tw T* (\027\020\002\027\023\031\021\026 \033\031\032\f\n\032\026\203\025\002 \033\ \032\002\003\n\017 \013\025\001\013\025 \027\020\001\031 \016\205\005\006\ \026\024\n\017 \023\025\021\025\025, \205)Tj /Span<>> BDC ( )Tj EMC (1)Tj /Span<>> BDC ( )Tj EMC (\227 \032\031\013\024\n\027\026\202\025\021\026\023\022\021\020\017 \t\027\ \025\211. \216)Tj /Span<>> BDC ( )Tj EMC (\t\027\002\016\025 \t)Tj /Span<>> BDC ( )Tj EMC (\t\031\033\t\025)Tj 0 Tw (-)Tj 0.055 Tw 0 -1.111 TD (\t\n\003 4)Tj /Span<>> BDC ( )Tj EMC (\(57,14%\) \033\026\203\025\031\021\024\026 \021\026\004\n\030\025\023\025\ \t\022 \027)Tj /Span<>> BDC ( )Tj EMC (\n\024\030\031\023\031\021\025\025 \032\031\026\021\025\003\026\203\025\025\ , \t\032\n\013 \021\026\005\023\007\030\031\021\025\002 \027)Tj /Span<>> BDC ( )Tj EMC (\n\024\030\031\023\031\021\025\025 \032\031\026\021\025\003\026\203\025\025\ )Tj 0.041 Tw 0 -1.111 TD (\t\n\t\024\026\027\025\023, \027)Tj /Span<>> BDC ( )Tj EMC [(\t\032\031\030\021\031\003, 32,5 \(17\22654\) \030\021\002. \200\032\031\ \021\025\032\n\027\026\021\025\031 )0.5(\026\005\t\203\031\t\t\n\027 \027\020\033\n\023\021\031\021\n \027\t\031\ \003 \033\026\203\025\031\021\024\026\003, \027)]TJ /Span<>> BDC ( )Tj EMC (3 \t\023\205\006\026\002\004)Tj /Span<>> BDC ( )Tj EMC (\227 )Tj 0.066 Tw T* (\t\025\202\003\n\t\024\n\003\025\002. \225\026\016\026 \032\031\033\026\032\ \026\203\025\025 \032\026\021 \005\020\023\026 \030\n\t\024\025\202\021\205\ \024\026 \205)Tj /Span<>> BDC ( )Tj EMC (\027\t\031\004 \033\026\203\025\031\021\024\n\027. \207\032\n\013\025 \032\ \031\033\026\032\026\203\025\025 \t\n\t\024\026\027\025\023\025 \n\024 3\ 7 )Tj 0.068 Tw T* (\030\n)Tj /Span<>> BDC ( )Tj EMC (142 \030\021\031\017, \027)Tj /Span<>> BDC ( )Tj EMC (\t\032\031\030\021\031\003, 79 \t\205\024\n\013. \216\026\013\205\205\003\ -\024\031\032\026\033\025\002 \033\032\n\027\n\030\025\023\026\t\022 \030\ \027\205\003 \033\026\203\025\031\021\024\026\003. \032\025)Tj /Span<>> BDC ( )Tj EMC (\025\t\033\n\023\022\016\n\027\026\021\025\025 \027\026\013\205)Tj 0 Tw (-)Tj 0.068 Tw T* [(\205\003-\024\031\032\026\033\025\025 \t\032\031\030\021\025\017 \t\032\n\ \013 \032\031\033\026\032\026\203\025\025 \032\026\021 \t\n\t\024\026\027\ \025\023 )0.5(53,5 \030\021\002. )0.5(\216)]TJ /Span<>> BDC ( )Tj EMC (\033\n\t\023\031\n\033\031\032\026\203\025\n\021\021\n\003 \033\031\032\025\ \n\030\031 \027\n \027\t\031\004 \t\023\205\006\026\002\004 )Tj 0.04 Tw T* (\n\024\003\031\006\026\023\026\t\022 \f\031\005\032\025\023\022\021\026\002\ \023\025\004\n\032\026\030\013\026 \t)Tj /Span<>> BDC ( )Tj EMC (\033\031\032\025\n\030\026\003\025 \021\n\032\003\n\024\031\032\003\025\025\ \027)Tj /Span<>> BDC ( )Tj EMC (\024\031\006\031\021\025\031 1 \003\031\t\002\203\026. \214\003\031\032\023\ \025 \030\027\n\031 \033\026\203\025\031\021\024\n\027 )Tj 0.023 Tw T* (\027)Tj /Span<>> BDC ( )Tj EMC (\t\032\n\013\025 50 \025)Tj /Span<>> BDC ( )Tj EMC (215 \030\021\031\017 \033\n\t\023\031 \n\033\031\032\026\203\025\025 \n\024\ \033\032\025\006\025\021, \021\031 \t\027\002\016\026\021\021\020\004 \t\ )Tj /Span<>> BDC ( )Tj EMC (\033\026\032\026\033\032\n\013\024\025\024\n\003.)Tj -0.02 Tc -0.003 Tw 8.91 0 0 9 90.7087 366.6487 Tm (\221\201\222\035\223\224\036\217\215\036: \240\212\220 \n\032\202\026\021\ \n\027 \003\026\023\n\202\n \024\026\016\026)Tj /Span<>> BDC ( )Tj EMC [(\227 \003\031\024\n\030 \030\025\026\202\021\n\t\024\025\013\025, \021\031\ \n\005\004\n\030\025\003\020\017 \030\023\002 \n\033\032\031\030\031\023\ \031\021\025\002 \n\005\b\031\003\026 \033\n\032\026\204\031\021\025\002\ )-20( )]TJ 0.052 Tw T* (\033\032\025)Tj /Span<>> BDC ( )Tj EMC (\207\225 \205)Tj /Span<>> BDC ( )Tj EMC (\n\021\013\n\202\031\003\026\024\n\023\n\202\025\006\031\t\013\025\004 \033\ \026\203\025\031\021\024\n\027. \212\026\016\027\025\024\025\031 \207\225\  \205)Tj /Span<>> BDC ( )Tj EMC (\033\026\203\025\031\021\024\n\027 \t)Tj /Span<>> BDC ( )Tj EMC (\021\031\017\024\032\n\033\031\021\025\031\017 \026\t\t\n\203\025\025\032\ \n\027\026\021\n \t)Tj /Span<>> BDC ( )Tj EMC (\027\020\t\n)Tj 0 Tc 0 Tw 8.91 0 0 9 493.4257 356.6487 Tm (-)Tj -0.02 Tc 0.06 Tw 8.91 0 0 9 90.7087 346.6487 Tm [(\013\n\017 \006\026\t\024\n\024\n\017 \t\031\033\t\025\t\026. \216\n \027\ \t\031\004 \t\023\205\006\026\002\004 \027\020\002\027\023\031\021\025\002\ \207\225 \t\023\031\030\205\031\024 \026\013\024\025\027\021\n \033\032\ \n\027\n\030\025\024\022 \030\025\026\202\021\n\t\024\025\013\205, \021\026\ \033\032\026\027\023\031\021\021\205\007)-20( )]TJ 0.076 Tw T* (\021\026)Tj /Span<>> BDC ( )Tj EMC (\027\020\030\031\023\031\021\025\031 \027\n\016\005\205\030\025\024\031\023\ \002 \013\026\013 \027)Tj /Span<>> BDC ( )Tj EMC (\023\n\013\205\t\031 \027\n\t\033\026\023\031\021\025\002, \024\026\013 \ \025)Tj /Span<>> BDC ( )Tj EMC (\027 \202\031\003\n\013\205\023\022\024\205\032\031. \035\031\006\031\021\ \025\031 \033\026\203\025\031\021\024\n\027 \t\n \207\225 \025)Tj /Span<>> BDC ( )Tj EMC (\013\023\025\021\025)Tj 0 Tc 0 Tw 8.91 0 0 9 493.4257 336.6487 Tm (-)Tj -0.02 Tc 0.152 Tw 8.91 0 0 9 90.7087 326.6487 Tm [(\013\n-\023\026\005\n\032\026\024\n\032\021\n\017 )0.5(\013\026\032\024\025\021\n\017 )0.5(\t\031\033\t\025\t\026 )0.5(\030\n\023\204\021\n )0.5(\033\032\n\027\n\030\025\024\t\002 \027)]TJ /Span<>> BDC ( )Tj EMC 24.305 0 Td [(\n\024\030\031\023\031\021\025\025 )0.5(\032\031\026\021\025\003\026\203\025\025 )0.5(\027)]TJ /Span<>> BDC ( )Tj EMC (\t\027\002\016\025 \t)Tj /Span<>> BDC ( )Tj EMC 13.921 0 Td [(\205\202\032\n\016\n\017 )0.5(\032\026\016\027\025\024\025\002)-19.9( )]TJ 0.166 Tw -38.226 -1.111 Td [(\t\031\033\024\025\006\031\t\013\n\202\n )0.5(\001\n\013\026. )0.5(\255\t\021\n\027\021\020\003\025 )0.5(\003\031\024\n\030\026\003\025 )0.5(\013\n\021\024\032\n\023\002 \025\021\f\031\013\203\025\025 \002\027\023\ \002\007\024\t\002 )0.5(\030\032\031\021\025\032\n\027\026\021\025\031 )0.5(\026\005\t\203\031\t\t\n\027 \025)]TJ /Span<>> BDC ( )Tj EMC 41.708 0 Td (\026\021\024\025\005\026\013)Tj 0 Tc 0 Tw 8.91 0 0 9 493.4257 316.6487 Tm (-)Tj -0.02 Tc 0.116 Tw 8.91 0 0 9 90.7087 306.6487 Tm (\024\031\032\025\026\023\022\021\026\002 \024\031\032\026\033\025\002, \013\ \n\024\n\032\026\002 \030\n\023\204\021\026 \005\020\024\022 \021\026\006\ \026\024\026 \030\n)Tj /Span<>> BDC ( )Tj EMC (\n\033\031\032\026\203\025\025 \025)Tj /Span<>> BDC ( )Tj EMC (\033\032\n\030\n\023\204\031\021\026 \027)Tj /Span<>> BDC ( )Tj EMC [(\033\n\t\023\031\n\033\031\032\026\203\025\n\021\021\n\003 \033\031\032\025\ \n\030\031)-20( )]TJ 0.052 Tw T* (\030\n)Tj /Span<>> BDC ( )Tj EMC (\021\n\032\003\n\024\031\032\003\025\025 \025)Tj /Span<>> BDC ( )Tj EMC (\032\031\202\032\031\t\t\026 \003\031\t\024\021\020\004 \033\032\025\016\ \021\026\013\n\027 \027\n\t\033\026\023\031\021\025\002. \216\026\013\205\ \205\003-\024\031\032\026\033\025\002 \002\027\023\002\031\024\t\002 \005\ \031\016\n\033\026\t\021\020\003 \025)Tj /Span<>> BDC ( )Tj EMC (\r\f\f\031\013\024\025\027)Tj 0 Tc 0 Tw 8.91 0 0 9 493.4257 296.6487 Tm (-)Tj -0.02 Tc 0.023 Tw 8.91 0 0 9 90.7087 286.6487 Tm (\021\020\003 \003\031\024\n\030\n\003 \027)Tj /Span<>> BDC ( )Tj EMC (\013\n\003\033\023\031\013\t\021\n\003 \023\031\006\031\021\025\025 \n\005\ \001\025\032\021\020\004 \033\n\t\023\031\n\033\031\032\026\203\025\n\021\ \021\020\004 \032\026\021 \205)Tj /Span<>> BDC ( )Tj EMC (\033\026\203\025\031\021\024\n\027 \t)Tj /Span<>> BDC ( )Tj EMC (\021\031\017\024\032\n\033\031\021\025\031\017.)Tj /T1_2 1 Tf 0.01 Tc 0.018 Tw 8 0 0 8 42.5596 271.3795 Tm [(\037\036\035\034\033\032\031\033)5( \030\036\027\032\026:)]TJ /T1_1 1 Tf 0 Tc 0.023 Tw 8.493 0 Td ( \n\t\024\032\020\017 \033\026\032\026\033\032\n\013\024\025\024, \033\031\ \032\025\026\021\026\023\022\021\026\002 \025\021\f\031\013\203\025\002,\ \026\005\t\203\031\t\t, \023\031\017\013\n\016, \021\031\017\024\032\n\033\ \031\021\025\002, \202\031\003\n\005\023\026\t\024\n\016)Tj /T1_2 1 Tf 0.01 Tc 0.018 Tw -8.493 -1.909 Td [(\023\030\030\036\033\020\027\032\026\025\023\033)5( \025\033)5( \023\f\033\036\027)5( \023\030\022\027\034\025\023\037\026)5( \024\023\025\026\025\030\023\021\027\032\026\025\023\017)]TJ 0 -1.909 TD [(\037\027\025\024\036\023\037\022)5( \023\025\022\033\021\033\030\027\032:)]TJ /T1_1 1 Tf 0 Tc 0.023 Tw 10.401 0 Td ( \026\027\024\n\032\020 \016\026\002\027\023\002\007\024 \n\005 \n\024\t\ \205\024\t\024\027\025\025 \013\n\021\f\023\025\013\024\026 \025\021\024\ \031\032\031\t\n\027)Tj /T1_2 1 Tf 0.033 Tc 0.04 Tw -10.401 -2.617 Td [(\020\036\017)4.7( \016\023\022\023\021\027\032\026\025\023\017:)]TJ /T1_3 1 Tf 0.023 Tc 0.045 Tw 9.212 0 Td ( \234\021\t\030\022\024\r\026)Tj /Span<>> BDC ( )Tj EMC (\221.\200., \221\024\002\024\035\036\r\026)Tj /Span<>> BDC ( )Tj EMC (\210.\202., \221\026\002\017\030\024\r)Tj /Span<>> BDC ( )Tj EMC (\025.\217., \203\024\r\017\022\024\r)Tj /Span<>> BDC ( )Tj EMC (\200.\202., \212\026\027\017\001\016\027)Tj /Span<>> BDC ( )Tj EMC (\025.\222., \215\026\030\024\r\017\004\027\017\022\024\r\026)Tj /Span<>> BDC ( )Tj EMC [(\213.\203. \212\017\026\020\027\024\f\021\017\022\026)23( )]TJ 0.109 Tw -9.217 -1.2 Td (\017)Tj /Span<>> BDC ( )Tj EMC (\035\036\004\036\027\017\036 \f\035\024\032\027\t\b \235\024\030\n \024\f\ \021\030\024\020\024 \023\026\030\026\023\030\024\022\021\017\021\026 \031\ )Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\024\023\031\b\024\035\036\r\t\n\017 \026\002\024\035\036\r\026\027\017\ \016\n\017 \f\017\f\021\036\n\t \022\030\024\r\017. )Tj /T1_1 1 Tf -0.023 Tw (\222\n\023\n\033\032\n\013\024\n\023\n\202\025\002.)Tj /T1_3 1 Tf 0 Tc 0 Tw 56.693 0 Td ( )Tj 0.023 Tc 0.024 Tw -56.693 -1.2 Td (2024; \021.)Tj /Span<>> BDC ( )Tj EMC (23, \225)Tj /Span<>> BDC ( )Tj EMC [(1, )0.5(\f.)]TJ /Span<>> BDC ( )Tj EMC (117\226128. https://doi.org/10.33878/2073-7556-2024-23-1-117-128)Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 0 Tc 0.023 Tw 18 0 0 18 88.9123 168.3638 Tm [(Diagnostics and tr)31(eatment of complicated perianal )]TJ 0.104 -1.167 Td [(abscess in patients with h)11(ematologic malignancies)]TJ 0 0 0 1 k /GS1 gs 14 0 0 14 42.5197 122.8599 Tm [(Sv)12(etlana\022)-23.2(V)62(.\022)-23.3(Sht)-20(yrk)11(ov)10(a, Olga\022)-23.3(A)-31(.\022)-23.3(Sobole)11(v)10(a, Kirill\022)-23.2(R.\022)-23.3(Sabir)20(ov)21(, )]TJ 0 -1.143 TD [(V)30(y)21(ach)11(eslav\022)-23.2(A)-31(.\022)-23.3(Novik)11(ov)21(, K)41(ar)31(en\022)-23.2(I.\022)-23.3(Ntanish)31.1(y)21(an, Elena\022)-23.3(N.\022)-23.2(P)20(ar)20(ovichnik)11(ov)10(a)]TJ 10 0 0 10 42.5197 89.1907 Tm [(National Medical Resear)31.1(ch Center for Hematology \(Nov)-20.9(y Z)21(yk)11(ov)10(sky pr)20.1(oe)21(z)21(d, 4, Moscow)22(, 1)125(2)23.1(5)127(1)112(6)58(7)127(, Russia\))]TJ ET 1 0.68 0 0.12 k /GS0 gs q 1 0 0 1 42.5197 585.1528 cm 0 0 m 0 0 l 0 -11.339 l 42.52 -11.339 l 42.52 0 l h f Q BT 0 0 0 0 k /T1_2 1 Tf 0 Tw 9 0 0 9 47.6607 576.2255 Tm (\021\033\r\035\f\033)Tj 1 0.68 0 0.12 k /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\033\030\031\030\213\b)-20.9(\035\231\213\233\t \021\032)50(\b)42(\032\231\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj /T1_4 1 Tf 25 0 0 25 504.7145 56.0378 Tm (117)Tj ET q 0 g 0 G 0 j 0 J /Fm1 Do Q 0 0 0 0 k 368.504 725.67 59.155 11.338 re f /PlacedPDF /MC0 BDC q 369.135 736.808 m 368.896 736.808 368.703 736.616 368.703 736.376 c 368.703 736.376 l 368.703 726.285 l 368.703 726.045 368.896 725.853 369.135 725.853 c 369.135 725.853 l 427.035 725.853 l 427.273 725.853 427.469 726.045 427.469 726.285 c 427.469 726.285 l 427.469 736.376 l 427.469 736.616 427.273 736.808 427.035 736.808 c 427.035 736.808 l h W n q 0 g -0.0000005 -10.9560913 -10.9560913 0.0000005 398.0855785 736.8086309 cm BX /Sh0 sh EX Q Q q 368.504 725.67 59.155 11.337 re W n 0 0 0 0.84 k q 1 0 0 1 385.2169 732.4249 cm 0 0 m -0.025 0.1 -0.063 0.196 -0.112 0.287 c -0.157 0.374 -0.218 0.451 -0.292 0.515 c -0.37 0.582 -0.46 0.632 -0.558 0.664 c -0.669 0.701 -0.786 0.719 -0.903 0.717 c -1.076 0.722 -1.247 0.681 -1.4 0.6 c -1.536 0.526 -1.652 0.42 -1.74 0.292 c -1.83 0.158 -1.895 0.008 -1.934 -0.149 c -2.018 -0.48 -2.018 -0.827 -1.934 -1.158 c -1.896 -1.316 -1.83 -1.466 -1.74 -1.602 c -1.653 -1.731 -1.536 -1.837 -1.4 -1.912 c -1.247 -1.993 -1.076 -2.033 -0.903 -2.029 c -0.774 -2.032 -0.647 -2.006 -0.528 -1.955 c -0.427 -1.906 -0.337 -1.837 -0.263 -1.753 c -0.185 -1.665 -0.124 -1.563 -0.082 -1.453 c -0.034 -1.338 0 -1.218 0.019 -1.094 c 0.635 -1.094 l 0.624 -1.297 0.578 -1.497 0.497 -1.684 c 0.421 -1.857 0.312 -2.015 0.175 -2.146 c 0.039 -2.277 -0.123 -2.379 -0.3 -2.446 c -0.492 -2.519 -0.695 -2.555 -0.9 -2.552 c -1.15 -2.557 -1.397 -2.506 -1.625 -2.404 c -1.829 -2.307 -2.01 -2.169 -2.157 -1.997 c -2.308 -1.821 -2.423 -1.617 -2.497 -1.397 c -2.655 -0.924 -2.655 -0.412 -2.497 0.061 c -2.423 0.281 -2.307 0.485 -2.157 0.661 c -2.01 0.833 -1.829 0.973 -1.625 1.07 c -1.398 1.174 -1.15 1.226 -0.9 1.222 c -0.707 1.223 -0.515 1.196 -0.329 1.14 c -0.159 1.088 0.001 1.006 0.144 0.898 c 0.278 0.793 0.39 0.662 0.473 0.513 c 0.562 0.349 0.615 0.167 0.629 -0.019 c 0 -0.019 l 0 0 l f Q q 1 0 0 1 386.3458 733.5723 cm 0 0 m 0.584 0 l 0.584 -1.328 l 0.662 -1.204 0.771 -1.103 0.9 -1.033 c 1.046 -0.951 1.213 -0.91 1.381 -0.914 c 1.627 -0.9 1.869 -0.979 2.058 -1.137 c 2.234 -1.312 2.325 -1.556 2.305 -1.803 c 2.305 -3.596 l 1.716 -3.596 l 1.716 -1.976 l 1.724 -1.817 1.678 -1.66 1.585 -1.53 c 1.486 -1.43 1.347 -1.379 1.206 -1.392 c 1.114 -1.39 1.024 -1.408 0.94 -1.445 c 0.865 -1.479 0.798 -1.529 0.744 -1.591 c 0.687 -1.656 0.645 -1.73 0.616 -1.812 c 0.586 -1.896 0.571 -1.986 0.571 -2.077 c 0.571 -3.615 l 0 -3.615 l 0 0 l f Q q 1 0 0 1 389.692 731.1235 cm 0 0 m 0 -0.099 0.014 -0.198 0.043 -0.292 c 0.069 -0.382 0.112 -0.466 0.17 -0.54 c 0.229 -0.611 0.304 -0.669 0.388 -0.709 c 0.486 -0.754 0.594 -0.776 0.702 -0.773 c 0.845 -0.78 0.987 -0.742 1.108 -0.664 c 1.217 -0.582 1.296 -0.468 1.336 -0.337 c 1.881 -0.337 l 1.827 -0.603 1.675 -0.838 1.456 -0.996 c 1.35 -1.073 1.231 -1.131 1.105 -1.169 c 0.971 -1.208 0.831 -1.229 0.691 -1.227 c 0.509 -1.227 0.328 -1.191 0.16 -1.121 c 0.007 -1.063 -0.13 -0.972 -0.244 -0.855 c -0.356 -0.73 -0.44 -0.583 -0.491 -0.422 c -0.548 -0.243 -0.576 -0.056 -0.574 0.133 c -0.575 0.313 -0.545 0.493 -0.486 0.664 c -0.426 0.826 -0.335 0.974 -0.22 1.102 c 0.004 1.375 0.338 1.534 0.691 1.535 c 0.883 1.539 1.072 1.495 1.243 1.408 c 1.402 1.326 1.541 1.209 1.649 1.067 c 1.759 0.922 1.838 0.757 1.883 0.582 c 1.932 0.396 1.945 0.203 1.92 0.013 c 0 0.013 l 0 0 l 1.342 0.377 m 1.335 0.468 1.315 0.557 1.283 0.643 c 1.253 0.724 1.209 0.798 1.153 0.863 c 1.097 0.922 1.03 0.97 0.957 1.004 c 0.874 1.043 0.783 1.063 0.691 1.062 c 0.6 1.062 0.509 1.044 0.425 1.009 c 0.345 0.976 0.273 0.926 0.213 0.863 c 0.153 0.799 0.105 0.724 0.072 0.643 c 0.037 0.559 0.017 0.468 0.014 0.377 c 1.355 0.377 l h f Q q 1 0 0 1 393.8116 731.7051 cm 0 0 m -0.012 0.144 -0.082 0.276 -0.194 0.366 c -0.31 0.452 -0.451 0.495 -0.595 0.489 c -0.675 0.488 -0.755 0.476 -0.831 0.452 c -0.918 0.424 -0.998 0.375 -1.062 0.311 c -1.142 0.229 -1.202 0.131 -1.24 0.024 c -1.29 -0.132 -1.312 -0.296 -1.304 -0.459 c -1.304 -0.569 -1.292 -0.677 -1.267 -0.784 c -1.244 -0.885 -1.202 -0.983 -1.145 -1.07 c -1.09 -1.154 -1.016 -1.224 -0.93 -1.275 c -0.833 -1.33 -0.722 -1.356 -0.611 -1.352 c -0.457 -1.357 -0.307 -1.301 -0.194 -1.195 c -0.078 -1.077 -0.005 -0.922 0.011 -0.757 c 0.587 -0.757 l 0.556 -1.055 0.419 -1.332 0.202 -1.538 c -0.022 -1.721 -0.306 -1.815 -0.595 -1.803 c -0.777 -1.806 -0.958 -1.771 -1.126 -1.7 c -1.293 -1.642 -1.445 -1.547 -1.57 -1.421 c -1.68 -1.297 -1.763 -1.151 -1.814 -0.993 c -1.87 -0.822 -1.898 -0.643 -1.896 -0.462 c -1.898 -0.276 -1.871 -0.091 -1.817 0.087 c -1.766 0.252 -1.682 0.405 -1.57 0.537 c -1.459 0.664 -1.323 0.766 -1.168 0.834 c -0.991 0.914 -0.798 0.955 -0.603 0.954 c -0.457 0.954 -0.311 0.935 -0.17 0.895 c -0.039 0.858 0.084 0.799 0.194 0.72 c 0.302 0.643 0.393 0.543 0.459 0.428 c 0.531 0.298 0.572 0.155 0.582 0.008 c 0 0.008 l 0 0 l f Q q 1 0 0 1 394.8712 733.5723 cm 0 0 m 0.577 0 l 0.577 -2.048 l 1.615 -0.985 l 2.322 -0.985 l 1.323 -1.944 l 2.417 -3.604 l 1.716 -3.604 l 0.919 -2.337 l 0.577 -2.669 l 0.577 -3.604 l 0 -3.604 l h f Q q 1 0 0 1 398.712 732.5762 cm 0 0 m 0.436 0 l 0.436 0.218 l 0.429 0.352 0.448 0.486 0.488 0.614 c 0.521 0.705 0.577 0.786 0.651 0.85 c 0.717 0.905 0.795 0.943 0.879 0.961 c 0.966 0.979 1.056 0.988 1.145 0.988 c 1.28 0.993 1.416 0.981 1.548 0.954 c 1.548 0.505 l 1.509 0.516 1.469 0.523 1.429 0.528 c 1.379 0.532 1.33 0.532 1.28 0.528 c 1.209 0.53 1.14 0.511 1.081 0.473 c 1.019 0.419 0.987 0.337 0.999 0.255 c 0.999 -0.011 l 1.498 -0.011 l 1.498 -0.441 l 1.009 -0.441 l 1.009 -2.622 l 0.436 -2.622 l 0.436 -0.428 l 0.005 -0.428 l 0.005 0 l 0 0 l f Q q 1 0 0 1 401.7535 729.8965 cm 0 0 m -0.191 -0.003 -0.381 0.032 -0.559 0.104 c -0.715 0.167 -0.856 0.264 -0.972 0.388 c -1.091 0.512 -1.181 0.659 -1.238 0.82 c -1.356 1.18 -1.356 1.567 -1.238 1.925 c -1.181 2.087 -1.091 2.234 -0.972 2.358 c -0.856 2.481 -0.715 2.578 -0.559 2.643 c -0.199 2.78 0.198 2.78 0.558 2.643 c 0.714 2.578 0.855 2.481 0.972 2.358 c 1.09 2.234 1.181 2.087 1.237 1.925 c 1.355 1.567 1.355 1.18 1.237 0.82 c 1.181 0.659 1.09 0.512 0.972 0.388 c 0.855 0.266 0.713 0.169 0.558 0.106 c 0.38 0.034 0.191 -0.002 0 0 c 0 0.454 m 0.115 0.451 0.23 0.479 0.332 0.534 c 0.424 0.586 0.502 0.659 0.562 0.746 c 0.624 0.836 0.669 0.936 0.695 1.041 c 0.752 1.26 0.752 1.491 0.695 1.71 c 0.669 1.816 0.625 1.916 0.562 2.005 c 0.502 2.091 0.423 2.163 0.332 2.215 c 0.123 2.323 -0.126 2.323 -0.335 2.215 c -0.427 2.163 -0.505 2.091 -0.566 2.005 c -0.628 1.916 -0.673 1.816 -0.699 1.71 c -0.756 1.491 -0.756 1.26 -0.699 1.041 c -0.672 0.936 -0.627 0.836 -0.566 0.746 c -0.506 0.659 -0.427 0.586 -0.335 0.534 c -0.232 0.478 -0.117 0.451 0 0.454 c f Q q 1 0 0 1 403.5515 732.5762 cm 0 0 m 0.531 0 l 0.531 -0.505 l 0.55 -0.43 0.583 -0.359 0.629 -0.297 c 0.681 -0.229 0.74 -0.167 0.807 -0.114 c 0.877 -0.059 0.956 -0.014 1.039 0.019 c 1.123 0.053 1.213 0.07 1.304 0.069 c 1.52 0.069 l 1.52 -0.486 l 1.395 -0.467 l 1.269 -0.467 l 1.178 -0.468 1.087 -0.488 1.004 -0.526 c 0.917 -0.565 0.839 -0.625 0.778 -0.699 c 0.716 -0.783 0.669 -0.878 0.643 -0.98 c 0.604 -1.104 0.584 -1.233 0.586 -1.362 c 0.586 -2.603 l 0.01 -2.603 l 0.01 0 l 0 0 l f Q q 1 0 0 1 409.0202 729.9683 cm 0 0 m -0.577 0 l -0.577 0.364 l -0.649 0.23 -0.759 0.121 -0.893 0.047 c -1.022 -0.029 -1.169 -0.07 -1.32 -0.072 c -1.595 -0.095 -1.866 0.002 -2.064 0.194 c -2.234 0.413 -2.316 0.687 -2.295 0.964 c -2.295 2.608 l -1.719 2.608 l -1.719 1.014 l -1.735 0.843 -1.689 0.67 -1.588 0.531 c -1.492 0.433 -1.357 0.382 -1.219 0.39 c -1.116 0.387 -1.012 0.406 -0.917 0.446 c -0.84 0.479 -0.772 0.531 -0.72 0.595 c -0.667 0.661 -0.63 0.738 -0.611 0.82 c -0.588 0.911 -0.577 1.003 -0.577 1.097 c -0.577 2.611 l 0 2.611 l 0 0 l f Q q 1 0 0 1 409.6413 732.5762 cm 0 0 m 0.545 0 l 0.545 -0.353 l 0.617 -0.209 0.736 -0.094 0.882 -0.026 c 1.03 0.04 1.19 0.073 1.352 0.072 c 1.535 0.075 1.717 0.038 1.883 -0.037 c 2.031 -0.106 2.161 -0.208 2.263 -0.334 c 2.366 -0.465 2.442 -0.615 2.489 -0.775 c 2.54 -0.948 2.566 -1.127 2.566 -1.307 c 2.566 -1.479 2.542 -1.651 2.497 -1.817 c 2.455 -1.973 2.385 -2.121 2.29 -2.252 c 2.099 -2.522 1.789 -2.682 1.458 -2.68 c 1.369 -2.681 1.28 -2.674 1.193 -2.659 c 1.11 -2.644 1.028 -2.618 0.951 -2.584 c 0.875 -2.552 0.802 -2.509 0.736 -2.457 c 0.671 -2.406 0.615 -2.343 0.571 -2.273 c 0.571 -3.575 l -0.005 -3.575 l -0.005 0 l 0 0 l 2.008 -1.307 m 2.008 -1.191 1.993 -1.076 1.963 -0.964 c 1.936 -0.859 1.89 -0.759 1.828 -0.669 c 1.768 -0.584 1.69 -0.514 1.599 -0.462 c 1.503 -0.409 1.395 -0.382 1.286 -0.385 c 1.072 -0.372 0.867 -0.467 0.738 -0.638 c 0.607 -0.836 0.543 -1.072 0.555 -1.31 c 0.554 -1.433 0.57 -1.557 0.603 -1.676 c 0.631 -1.781 0.68 -1.879 0.747 -1.965 c 0.809 -2.044 0.886 -2.109 0.975 -2.157 c 1.071 -2.206 1.178 -2.23 1.286 -2.229 c 1.401 -2.232 1.517 -2.205 1.618 -2.148 c 1.708 -2.096 1.785 -2.025 1.843 -1.939 c 1.903 -1.85 1.945 -1.751 1.968 -1.646 c 1.995 -1.535 2.008 -1.421 2.008 -1.307 c f Q q 1 0 0 1 415.1662 729.9683 cm 0 0 m -0.545 0 l -0.545 0.353 l -0.616 0.211 -0.734 0.099 -0.879 0.034 c -1.027 -0.031 -1.187 -0.065 -1.349 -0.064 c -1.532 -0.067 -1.714 -0.03 -1.88 0.045 c -2.028 0.113 -2.158 0.214 -2.26 0.34 c -2.364 0.47 -2.441 0.62 -2.486 0.781 c -2.538 0.958 -2.564 1.143 -2.563 1.328 c -2.568 1.536 -2.536 1.742 -2.468 1.938 c -2.41 2.097 -2.319 2.242 -2.202 2.364 c -2.101 2.471 -1.977 2.555 -1.838 2.608 c -1.705 2.659 -1.563 2.685 -1.421 2.685 c -1.338 2.685 -1.256 2.678 -1.174 2.664 c -1.091 2.648 -1.01 2.624 -0.932 2.589 c -0.855 2.556 -0.783 2.514 -0.717 2.462 c -0.652 2.411 -0.597 2.349 -0.553 2.279 c -0.553 3.606 l 0.024 3.606 l 0.024 0 l 0 0 l -2.008 1.277 m -2.009 1.166 -1.994 1.056 -1.965 0.948 c -1.939 0.845 -1.896 0.748 -1.835 0.661 c -1.777 0.578 -1.699 0.508 -1.61 0.459 c -1.404 0.355 -1.162 0.355 -0.956 0.459 c -0.866 0.512 -0.789 0.585 -0.73 0.671 c -0.671 0.762 -0.626 0.862 -0.6 0.966 c -0.572 1.076 -0.558 1.188 -0.558 1.301 c -0.543 1.542 -0.612 1.781 -0.751 1.979 c -0.88 2.14 -1.078 2.229 -1.283 2.22 c -1.402 2.224 -1.52 2.196 -1.623 2.138 c -1.714 2.083 -1.793 2.009 -1.852 1.92 c -1.911 1.828 -1.954 1.725 -1.977 1.617 c -1.999 1.505 -2.01 1.392 -2.008 1.277 c f Q q 1 0 0 1 417.9787 730.5499 cm 0 0 m -0.004 -0.052 0.005 -0.104 0.026 -0.151 c 0.052 -0.185 0.094 -0.202 0.136 -0.197 c 0.197 -0.197 l 0.223 -0.2 0.25 -0.2 0.276 -0.197 c 0.276 -0.595 l 0.199 -0.619 l 0.101 -0.64 l 0 -0.656 l -0.085 -0.656 l -0.187 -0.66 -0.288 -0.635 -0.377 -0.584 c -0.461 -0.528 -0.516 -0.437 -0.528 -0.337 c -0.648 -0.451 -0.792 -0.534 -0.951 -0.579 c -1.106 -0.628 -1.269 -0.654 -1.432 -0.656 c -1.546 -0.657 -1.659 -0.641 -1.769 -0.608 c -1.872 -0.579 -1.967 -0.531 -2.053 -0.468 c -2.136 -0.405 -2.203 -0.324 -2.25 -0.231 c -2.3 -0.127 -2.326 -0.012 -2.324 0.104 c -2.33 0.24 -2.299 0.375 -2.236 0.497 c -2.181 0.594 -2.101 0.675 -2.005 0.733 c -1.905 0.791 -1.795 0.833 -1.681 0.855 c -1.562 0.88 -1.442 0.899 -1.32 0.914 c -1.222 0.933 -1.123 0.947 -1.022 0.956 c -0.938 0.963 -0.855 0.977 -0.773 0.999 c -0.708 1.014 -0.649 1.046 -0.6 1.092 c -0.556 1.144 -0.533 1.211 -0.536 1.28 c -0.534 1.344 -0.553 1.408 -0.59 1.46 c -0.624 1.507 -0.668 1.544 -0.72 1.569 c -0.775 1.596 -0.834 1.613 -0.895 1.62 c -0.955 1.624 -1.016 1.624 -1.076 1.62 c -1.215 1.625 -1.354 1.591 -1.474 1.519 c -1.581 1.45 -1.647 1.333 -1.652 1.206 c -2.231 1.206 l -2.227 1.354 -2.185 1.498 -2.108 1.625 c -2.041 1.733 -1.951 1.824 -1.843 1.891 c -1.729 1.96 -1.603 2.007 -1.472 2.032 c -1.329 2.072 -1.183 2.098 -1.036 2.109 c -0.908 2.109 -0.781 2.096 -0.656 2.069 c -0.538 2.044 -0.425 2 -0.321 1.939 c -0.225 1.88 -0.143 1.8 -0.083 1.705 c -0.02 1.599 0.012 1.478 0.008 1.354 c 0.008 0.013 l 0 0 l -0.576 0.728 m -0.674 0.667 -0.785 0.631 -0.9 0.624 c -1.028 0.612 -1.155 0.594 -1.283 0.571 c -1.343 0.561 -1.402 0.547 -1.46 0.528 c -1.515 0.511 -1.566 0.485 -1.612 0.451 c -1.657 0.419 -1.692 0.376 -1.716 0.327 c -1.742 0.267 -1.755 0.203 -1.753 0.138 c -1.755 0.079 -1.735 0.021 -1.697 -0.024 c -1.661 -0.067 -1.615 -0.103 -1.564 -0.127 c -1.509 -0.154 -1.451 -0.171 -1.392 -0.181 c -1.335 -0.19 -1.278 -0.196 -1.222 -0.197 c -1.152 -0.196 -1.083 -0.188 -1.015 -0.173 c -0.94 -0.156 -0.87 -0.127 -0.805 -0.088 c -0.74 -0.048 -0.684 0.004 -0.64 0.066 c -0.594 0.134 -0.571 0.215 -0.574 0.297 c -0.574 0.725 l h f Q q 1 0 0 1 418.3371 732.5762 cm 0 0 m 0.434 0 l 0.434 0.784 l 0.996 0.784 l 0.996 0 l 1.527 0 l 1.527 -0.43 l 0.996 -0.43 l 0.996 -1.822 l 0.993 -1.874 0.993 -1.927 0.996 -1.979 c 1 -2.018 1.011 -2.056 1.031 -2.09 c 1.05 -2.122 1.079 -2.146 1.113 -2.159 c 1.162 -2.177 1.213 -2.185 1.265 -2.183 c 1.387 -2.183 l 1.428 -2.181 1.469 -2.175 1.509 -2.165 c 1.509 -2.608 l 1.323 -2.629 l 1.261 -2.633 1.199 -2.633 1.137 -2.629 c 1.013 -2.633 0.89 -2.619 0.771 -2.587 c 0.688 -2.564 0.613 -2.52 0.553 -2.459 c 0.499 -2.4 0.462 -2.328 0.446 -2.25 c 0.427 -2.155 0.416 -2.059 0.415 -1.963 c 0.415 -0.428 l -0.019 -0.428 l -0.019 0 l 0 0 l f Q q 1 0 0 1 420.7277 731.1235 cm 0 0 m 0 -0.099 0.014 -0.198 0.042 -0.292 c 0.068 -0.382 0.112 -0.466 0.17 -0.54 c 0.229 -0.611 0.303 -0.669 0.388 -0.709 c 0.486 -0.754 0.593 -0.776 0.701 -0.773 c 0.845 -0.78 0.987 -0.742 1.107 -0.664 c 1.216 -0.582 1.296 -0.468 1.336 -0.337 c 1.88 -0.337 l 1.827 -0.603 1.674 -0.838 1.456 -0.996 c 1.349 -1.073 1.231 -1.131 1.105 -1.169 c 0.973 -1.208 0.836 -1.228 0.699 -1.227 c 0.512 -1.23 0.327 -1.196 0.154 -1.126 c 0.003 -1.066 -0.133 -0.973 -0.244 -0.855 c -0.356 -0.73 -0.44 -0.583 -0.491 -0.422 c -0.548 -0.243 -0.576 -0.056 -0.574 0.133 c -0.575 0.313 -0.546 0.493 -0.486 0.664 c -0.426 0.826 -0.336 0.974 -0.221 1.102 c 0.002 1.374 0.334 1.532 0.685 1.535 c 0.877 1.539 1.067 1.495 1.238 1.408 c 1.396 1.326 1.535 1.209 1.644 1.067 c 1.753 0.922 1.833 0.757 1.878 0.582 c 1.927 0.396 1.939 0.203 1.915 0.013 c -0.002 0.013 l 0 0 l 1.341 0.377 m 1.335 0.468 1.315 0.557 1.283 0.643 c 1.253 0.724 1.209 0.798 1.153 0.863 c 1.096 0.926 1.027 0.978 0.951 1.014 c 0.868 1.054 0.777 1.074 0.685 1.073 c 0.594 1.073 0.504 1.055 0.419 1.02 c 0.339 0.986 0.267 0.937 0.207 0.874 c 0.147 0.81 0.099 0.735 0.066 0.653 c 0.031 0.569 0.011 0.479 0.008 0.388 c 1.349 0.388 l h f Q q 1 0 0 1 423.5192 730.7994 cm 0 0 m 0.002 -0.142 0.073 -0.274 0.191 -0.353 c 0.312 -0.423 0.45 -0.458 0.59 -0.454 c 0.651 -0.458 0.711 -0.458 0.773 -0.454 c 0.839 -0.447 0.904 -0.43 0.967 -0.406 c 1.024 -0.385 1.075 -0.349 1.116 -0.303 c 1.155 -0.252 1.174 -0.189 1.168 -0.125 c 1.166 -0.057 1.138 0.008 1.089 0.056 c 1.033 0.107 0.967 0.146 0.895 0.17 c 0.809 0.201 0.72 0.226 0.629 0.245 c 0.329 0.33 l 0.224 0.352 0.121 0.38 0.019 0.415 c -0.076 0.446 -0.166 0.491 -0.247 0.55 c -0.327 0.608 -0.391 0.683 -0.436 0.771 c -0.486 0.873 -0.511 0.986 -0.507 1.1 c -0.512 1.226 -0.475 1.351 -0.404 1.456 c -0.333 1.551 -0.243 1.63 -0.138 1.687 c -0.028 1.747 0.092 1.788 0.215 1.809 c 0.337 1.832 0.462 1.843 0.587 1.843 c 0.716 1.844 0.845 1.83 0.972 1.801 c 1.09 1.774 1.202 1.727 1.304 1.663 c 1.404 1.598 1.488 1.513 1.551 1.413 c 1.621 1.3 1.663 1.173 1.676 1.041 c 1.076 1.041 l 1.059 1.155 0.989 1.253 0.887 1.307 c 0.78 1.355 0.665 1.38 0.547 1.378 c 0.5 1.381 0.452 1.381 0.403 1.378 c 0.35 1.373 0.298 1.36 0.247 1.341 c 0.2 1.325 0.157 1.297 0.122 1.262 c 0.087 1.224 0.069 1.174 0.071 1.124 c 0.069 1.058 0.096 0.995 0.146 0.951 c 0.202 0.903 0.267 0.866 0.337 0.842 c 0.424 0.811 0.512 0.786 0.603 0.768 c 0.917 0.701 l 1.021 0.678 1.124 0.65 1.224 0.616 c 1.319 0.584 1.409 0.539 1.49 0.481 c 1.662 0.359 1.762 0.16 1.755 -0.05 c 1.76 -0.189 1.723 -0.326 1.649 -0.443 c 1.582 -0.551 1.491 -0.642 1.384 -0.709 c 1.267 -0.778 1.14 -0.827 1.007 -0.855 c 0.873 -0.885 0.735 -0.9 0.598 -0.9 c 0.443 -0.902 0.29 -0.883 0.141 -0.845 c 0.01 -0.812 -0.114 -0.753 -0.223 -0.674 c -0.324 -0.601 -0.407 -0.504 -0.465 -0.393 c -0.527 -0.269 -0.559 -0.131 -0.558 0.008 c 0.019 0.008 l 0 0 l f Q 0.146 0.941 0.992 0.044 k q 1 0 0 1 372.9062 729.3892 cm 0 0 m 3.612 2.406 l 3.612 5.296 l 0 5.296 l h f Q 0 0.889 0.676 0 k q 1 0 0 1 376.5186 729.3892 cm 0 0 m -3.612 2.406 l -3.612 5.296 l 0 5.296 l h f Q 0.694 0.076 0.209 0 k q 1 0 0 1 374.7125 735.3145 cm 0 0 m -2.2 0 -3.984 -1.784 -3.984 -3.984 c -3.984 -6.184 -2.2 -7.968 0 -7.968 c 2.2 -7.968 3.984 -6.184 3.984 -3.984 c 3.984 -1.784 2.2 0 0 0 c 0 -6.993 m -1.662 -6.993 -3.009 -5.646 -3.009 -3.984 c -3.009 -2.322 -1.662 -0.975 0 -0.975 c 1.662 -0.975 3.009 -2.322 3.009 -3.984 c 3.009 -5.646 1.662 -6.993 0 -6.993 c f Q 0 0.235 0.86 0 k q 1 0 0 1 376.9137 729.2803 cm 0 0 m -1.118 -1.208 -3.015 -1.281 -4.237 -0.159 c -5.159 0.688 -5.459 2.005 -4.999 3.156 c -5.833 3.687 l -6.736 1.681 -5.843 -0.679 -3.836 -1.582 c -2.218 -2.311 -0.312 -1.881 0.836 -0.528 c 0 0 l f Q 0 0 0 0.6 k q 1 0 0 1 369.1348 736.8087 cm 0 0 m -0.238 0 -0.432 -0.193 -0.432 -0.432 c -0.432 -10.524 l -0.432 -10.763 -0.238 -10.956 0 -10.956 c 57.901 -10.956 l 58.139 -10.956 58.333 -10.763 58.333 -10.524 c 58.333 -0.432 l 58.333 -0.193 58.139 0 57.901 0 c h 57.901 -11.155 m 0 -11.155 l -0.348 -11.155 -0.631 -10.872 -0.631 -10.524 c -0.631 -0.432 l -0.631 -0.084 -0.348 0.199 0 0.199 c 57.901 0.199 l 58.249 0.199 58.532 -0.084 58.532 -0.432 c 58.532 -10.524 l 58.532 -10.872 58.249 -11.155 57.901 -11.155 c f Q EMC Q endstream endobj 1214 0 obj <> endobj 1219 0 obj <>stream Adobe Illustrator CS6 (Windows) 2021-04-12T11:45:36+05:00 2021-06-02T10:28:09+05:00 2021-06-02T10:28:09+05:00 1 False False 20.868494 3.999928 Millimeters Cyan Magenta Yellow Black Default Swatch Group 0 C=0 M=24 Y=86 K=0 PROCESS 100.000000 CMYK 0.000000 23.504999 86.022697 0.000000 C=69 M=8 Y=21 K=0 PROCESS 100.000000 CMYK 69.369003 7.635600 20.892700 0.000000 C=0 M=89 Y=68 K=0 PROCESS 100.000000 CMYK 0.000000 88.946404 67.623398 0.000000 C=15 M=94 Y=99 K=4 PROCESS 100.000000 CMYK 14.578501 94.070297 99.160698 4.416000 C=0 M=0 Y=0 K=84 PROCESS 100.000000 CMYK 0.000000 0.000000 0.000000 84.000000 C=0 M=0 Y=0 K=35 PROCESS 100.000000 CMYK 0.000000 0.000000 0.000000 35.000000 C=0 M=0 Y=0 K=60 PROCESS 100.000000 CMYK 0.000000 0.000000 0.000000 60.000004 Document application/pdf proof:pdf xmp.did:804244B35A9BEB118A6FC3C256996E2F uuid:08e30110-bdb7-4606-97ca-63fb62cbcecc uuid:21079f76-f6d7-4329-b725-f2fb35af5114 uuid:722f8893-0b3c-4402-87fb-c713f1fa0e26 uuid:21079f76-f6d7-4329-b725-f2fb35af5114 uuid:21079f76-f6d7-4329-b725-f2fb35af5114 proof:pdf saved xmp.iid:804244B35A9BEB118A6FC3C256996E2F 2021-04-12T11:45:42+05:00 Adobe Illustrator CS6 (Windows) / endstream endobj 1218 0 obj <>/Border[0 0 0]/H/N/Rect[366.504 739.008 429.659 723.67]/Subtype/Link/Type/Annot>> endobj 1220 0 obj <> endobj 1210 0 obj [1221 0 R 1222 0 R 1223 0 R 1224 0 R 1225 0 R 1226 0 R 1227 0 R 1228 0 R 1229 0 R 1230 0 R 1231 0 R 1232 0 R 1233 0 R 1234 0 R 1235 0 R 1236 0 R 1237 0 R 1238 0 R 1239 0 R 1240 0 R 1241 0 R 1242 0 R 1243 0 R 1244 0 R 1245 0 R 1246 0 R 1247 0 R 1248 0 R 1249 0 R 1250 0 R 1251 0 R 1252 0 R 1253 0 R 1254 0 R 1255 0 R 1256 0 R 1257 0 R 1258 0 R 1259 0 R 1260 0 R 1261 0 R 1262 0 R 1263 0 R 1264 0 R 1265 0 R 1266 0 R] endobj 1211 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.011 Tc 0.394 Tw 8 0 0 8 70.8661 731.2159 Tm (23.)Tj /Span<>> BDC ( )Tj EMC 1.838 0 Td [(Bar)-23.6(b)0.5(ar)-32.6(a)]TJ /Span<>> BDC ( )Tj EMC [(G, S)-23.6(caiol)-30.6(i)]TJ /Span<>> BDC 8.024 0 Td ( )Tj EMC [(E, Bar)-23.6(bar)-31.5(o)]TJ /Span<>> BDC ( )Tj EMC [(MR)0.5(, e)-11.6(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Gut micr)-31.5(obio)17.4(t)15.4(a,)11( )]TJ 0 Tc 0.308 Tw -9.863 -1.25 Td [(me)-12(t)15(abol)30(ome )0.6(and )0.6(immune )0.5(signa)15.1(tur)-24(es )0.6(in )0.5(p)32(a)15(t)-32(ients )0.6(wi)-23.9(t)-13(h )0.5(uncom)10(pl)-30.9(i)]TJ 0 Tw (-)Tj 0.067 Tw 0 -1.25 TD [(ca)15(ted di)-16(ver)-22(t)-32(icul)-15.9(ar disease. )]TJ /T1_1 1 Tf 0 Tw (Gut)Tj /T1_0 1 Tf 0.067 Tw [(. 2017;66\(7\):1252\22661. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1136/)Tj T* (gutjnl-2016-312377)Tj 0 0 0 1 k /GS1 gs 0.017 Tc 0.605 Tw T* (24.)Tj /Span<>> BDC ( )Tj EMC 1.862 0 Td [(F)20.4(al)-15.6(a)-16.7(gas)]TJ /Span<>> BDC ( )Tj EMC 3.947 0 Td [(ME, S)-15.6(iak)-16.6(avell)-15.6(as)]TJ /Span<>> BDC ( )Tj EMC (E. )Tj /T1_1 1 Tf 9.388 0 Td [(Bactero)0.5(ides, )0.5(Prev)13.4(o)13.4(tella)]TJ /T1_0 1 Tf [(, )0.5(and)17( )]TJ /T1_1 1 Tf 0.01 Tc -0.01 Tw -15.198 -1.25 Td [(P)15(or)-18.1(ph)12(yromonas)]TJ /T1_0 1 Tf 0.374 Tw [( spec)-24(ies: a r)-24(ev)-16.1(iew of ant)-32(ibio)17(t)-32(ic r)-24(esist)14.9(ance and)10( )]TJ 0.008 Tc 0.35 Tw T* [(t)-13.4(her)-33.4(apeut)-32.4(ic opt)-32.4(ions. )]TJ /T1_1 1 Tf [(Int J Antimicrob A)10.6(g)11.5(ents)]TJ /T1_0 1 Tf [(. 2000;15\(1\):1\2269.)8( )]TJ 0 Tc 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1016/s0924-8579\(99\)00164-8)Tj 0 0 0 1 k /GS1 gs -0.002 Tw -1.847 -1.25 Td (25.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Ar)-22(umugam)]TJ /Span<>> BDC ( )Tj EMC [(M, R)-10(aes)]TJ /Span<>> BDC ( )Tj EMC [(J, P)30(elle)-12(t)-31.9(ier)]TJ /Span<>> BDC ( )Tj EMC [(E, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Enter)-31.9(o)17(t)-10(ypes of t)-13(he human )]TJ 0.322 Tw -1.796 -1.25 Td [(gut micr)-31.9(obiome. )]TJ /T1_1 1 Tf 0 Tw [(N)18(ature)]TJ /T1_0 1 Tf 0.322 Tw [(. )0.5(2011;473\(7346\):174\22680. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1038/)Tj T* [(na)15(tur)-23.9(e09944)]TJ 0 0 0 1 k /GS1 gs 0.018 Tw 29.055 12.5 Td (26.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(W)16(u)]TJ /Span<>> BDC ( )Tj EMC (GD, Chen)Tj /Span<>> BDC ( )Tj EMC [(J, Hof)-56(fmann)]TJ /Span<>> BDC ( )Tj EMC [(C, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. L)-32(ink)-16(ing l)30(ong-ter)-15.9(m die)-12(t)15(ar)-24(y p)32(a)15(t)]TJ 0 Tw (-)Tj 0.003 Tw -1.796 -1.25 Td [(ter)-15(ns wi)-23.9(t)-13(h gut micr)-32(obial enter)-32(o)17(t)-9.9(ypes. )]TJ /T1_1 1 Tf 0 Tw (Science)Tj /T1_0 1 Tf 0.003 Tw (. 2011;334\(6052\):105\226)Tj 0.023 Tw T* [(8. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw [(10.1126/sc)-24(ience.1208344)]TJ 0 0 0 1 k /GS1 gs 0.323 Tw T* (27.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(K)25(oe)-12(t)-13(h)]TJ /Span<>> BDC ( )Tj EMC 2.912 0 Td [(RA, )0.5(W)12(ang)]TJ /Span<>> BDC ( )Tj EMC 4.551 0 Td [(Z, )0.5(L)35(ev)-16(ison)]TJ /Span<>> BDC ( )Tj EMC [(BS, )0.5(e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. )0.5(Intest)-32(inal )0.5(micr)-32(obio)17(t)15(a )]TJ 0.062 Tw -9.259 -1.25 Td [(me)-12(t)15(abol)-30.9(is)26(m of L-car)-15(ni)-23.9(t)-32(ine, a nutr)-36.9(ient in r)-23.9(ed mea)15(t, p)25(r)-32(omo)17(tes a)15(t)-13(her)-31.9(o)]TJ 0 Tw (-)Tj T* [(scler)-31.9(osis. )]TJ /T1_1 1 Tf 0.023 Tw 4.008 0 Td [(N)18(at Med.)]TJ /T1_0 1 Tf [( 2013;19\(5\):576\22685. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1038/nm.3145)Tj 0 0 0 1 k /GS1 gs 0.154 Tw -4.008 -1.25 Td (28.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(R)11(oa)-17(ger)]TJ /Span<>> BDC ( )Tj EMC [(HM, L)-32(icht)]TJ /Span<>> BDC ( )Tj EMC [(TR, P)10(oulsen)]TJ /Span<>> BDC ( )Tj EMC [(SK, e)-11.9(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Micr)-32(obial enter)-32(o)17(t)-10(ypes, )]TJ 0.005 Tc 0.35 Tw -1.796 -1.25 Td [(infer)-24.3(r)-24.3(ed b)11.7(y t)-13.3(he )]TJ /T1_1 1 Tf -0.005 Tw [(Prev)12.6(o)12.7(tella)]TJ /T1_0 1 Tf [(-t)16.6(o-)]TJ /T1_1 1 Tf (Bacteroides)Tj /T1_0 1 Tf 0.35 Tw [( r)-33.3(a)14.6(t)-32.3(io, r)-24.3(emained st)14.6(able)5.1( )]TJ 0 Tc 0.289 Tw T* [(dur)-37(ing a 6-mont)-12.9(h r)-33(and)-16(omized contr)-32(olled die)-12(t inter)-32(vent)-31.9(ion wi)-24(t)-13(h )]TJ 0.261 Tw T* [(t)-13(he )0.6(new )0.6(nor)-24(dic )0.6(die)-12(t. )]TJ /T1_1 1 Tf 9.421 0 Td [(Appl )0.6(En)11(viron )0.6(Microbiol.)]TJ /T1_0 1 Tf [( )0.5(2014;80\(3\):1142\2269. )]TJ 0 Tw -9.421 -1.25 Td [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1128/AEM.03549-13)Tj /T1_2 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 70.936 603.0499 Tm (REFERENCES)Tj 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0 Tc 0.28 Tw 8 0 0 8 70.8661 590.2152 Tm (1.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (Chen)Tj /Span<>> BDC ( )Tj EMC (Y, Zhou)Tj /Span<>> BDC ( )Tj EMC [(J, W)12(ang)]TJ /Span<>> BDC ( )Tj EMC [(L. R)10.9(ole and mechanis)26(m of gut micr)-31.9(o)]TJ 0 Tw (-)Tj 0.048 Tw -1.296 -1.25 Td [(bio)17(t)15(a in human disease. )]TJ /T1_1 1 Tf [(F)27(ront Cell Infect Microbiol.)]TJ /T1_0 1 Tf ( 2021;11:625913. )Tj 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td [(10.3389/fc)-24(imb.2021.625913)]TJ 0 0 0 1 k /GS1 gs 0.142 Tw -1.847 -1.25 Td (2.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (Hasan)Tj /Span<>> BDC ( )Tj EMC [(N, Y)50(ang)]TJ /Span<>> BDC ( )Tj EMC [(H. F)20(a)-17(c)-16(t)17(or)-10(s af)-56(fec)-15.9(t)-32(ing t)-13(he com)10(posi)-24(t)-32(ion of t)-12.9(he gut )]TJ 0.018 Tw -1.296 -1.25 Td [(micr)-32(obio)17(t)15.1(a, and )0.5(i)-23.9(ts )0.5(modul)-16(a)15(t)-32(ion. )]TJ /T1_1 1 Tf 12.999 0 Td [(P)15(eer)]TJ /Span<>> BDC ( )Tj EMC 1.953 0 Td (J.)Tj /T1_0 1 Tf [( )0.5(2019;7:e7502. )0.5(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw 8.946 0 Td (10.7717/)Tj -23.899 -1.25 Td [(peer)-46(j.7502)]TJ 0 0 0 1 k /GS1 gs 0.029 Tw T* (3.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Y)50(ang)]TJ /Span<>> BDC ( )Tj EMC (M, Hong)Tj /Span<>> BDC ( )Tj EMC (G, Jin)Tj /Span<>> BDC ( )Tj EMC [(Y, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Mucosal-asso)-16(c)-23.9(ia)15(ted micr)-32(obio)17(t)15(a o)17(t)-13(her )]TJ 0.286 Tw -1.296 -1.25 Td [(t)-13(han l)35(uminal micr)-32(obio)17(t)15(a has a cl)30(ose r)-23.9(el)-16(a)15(t)-32(ionship wi)-24(t)-13(h diar)-24(r)-24(hea-)]TJ 0.195 Tw T* [(p)25(r)-24(ed)-16(ominant ir)-24(r)-37(i)-23.9(t)15(able bo)-14(wel syndr)-32(ome. )]TJ /T1_1 1 Tf [(F)27(ront Cell Infect Microbiol.)]TJ /T1_0 1 Tf 0 Tw ( )Tj 0.023 Tw T* [(2020;10:515614. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw [(10.3389/fc)-24(imb.2020.515614)]TJ 0 0 0 1 k /GS1 gs 0.154 Tw T* (4.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Ar)-24(d)42(a)15(tsk)-16.9(a)15(y)22(a)]TJ /Span<>> BDC ( )Tj EMC [(M.D., A)-25(chk)-17(asov)]TJ /Span<>> BDC ( )Tj EMC [(S.I., V)30(esel)30(ov)]TJ /Span<>> BDC ( )Tj EMC [(V.V., e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Kl)-30.9(inichesk)-16(ie )]TJ 0.026 Tc 0.949 Tw -1.296 -1.25 Td [(r)-24.4(ekomend)41.5(a)14.6(tsi)-16.4(i. Di)-16.4(ver)-22.4(t)-32.4(ikul)34.6(y)21.5(ar)-15.4(na)14.6(y)21.6(a bolezn\245. )]TJ /T1_1 1 Tf -0.026 Tw [(K)17.6(olop)45.6(roktologia)]TJ /T1_0 1 Tf 0 Tc 0 Tw (. )Tj 0.18 Tw T* [(2021;20\(3\):10\22627. \(In Russ.\). d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.33878/2073-7556-2021-20-)Tj T* (3-10-27)Tj 0 0 0 1 k /GS1 gs 0.098 Tw T* (5.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(R)13(ei)-24(t)15(ano)]TJ /Span<>> BDC ( )Tj EMC [(E, F)10(r)-33(ancone)]TJ /Span<>> BDC ( )Tj EMC (E, Bona)Tj /Span<>> BDC ( )Tj EMC [(E, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Gut micr)-31.9(obio)17(t)15(a asso)-16(c)-24(ia)15(t)-32(ion )]TJ -0.013 Tw -1.296 -1.25 Td [(wi)-24(t)-12.9(h di)-16(ver)-21.9(t)-32(icul)-16(ar disease p)32(a)15(t)-13(ho)-16(genesis and p)25(r)-31.9(o)-16(gr)-24(ession: a sy)-13(stema)15.1(t)-32(ic )]TJ 0 Tw T* [(r)-24(ev)-15.9(iew. )]TJ /T1_1 1 Tf 0.023 Tw 3.194 0 Td (Dig Dis Sci.)Tj /T1_0 1 Tf [( 2022. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1007/s10620-022-07600-x)Tj 0 0 0 1 k /GS1 gs 0.086 Tw -3.194 -1.25 Td (6.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(S)-24(chief)-56(fer)]TJ /Span<>> BDC ( )Tj EMC [(KM, Sabe)-11(y)]TJ /Span<>> BDC ( )Tj EMC [(K, W)13.9(r)-36.9(ight)]TJ /Span<>> BDC ( )Tj EMC [(JR, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. T)47(he micr)-32(obial ecosy)-12.9(stem )]TJ 0.015 Tw -1.296 -1.25 Td [(dist)-32(inguishes )0.6(chr)-32(onicall)35(y )0.5(diseased )0.5(t)-32(issue fr)-31.9(om )0.5(ad)17(ja)-17(cent )0.5(t)-32(issue )0.5(in )0.5(t)-13(he )]TJ 0.108 Tw T* [(sigmoid col)30(on of chr)-31.9(onic, r)-24(ecur)-24(r)-23.9(ent di)-16(ver)-22(t)-32(icul)-30.9(i)-24(t)-32(is p)32(a)15(t)-32(ients. )]TJ /T1_1 1 Tf [(Sci R)21(ep.)]TJ /T1_0 1 Tf 0 Tw ( )Tj 0.023 Tw -0 -1.25 Td [(2017;7\(1\):8467. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1038/s41598-017-06787-8)Tj 0 0 0 1 k /GS1 gs 0.007 Tc 0.35 Tw T* (7.)Tj /Span<>> BDC ( )Tj EMC 1.317 0 Td [(P)-24(icc)-24(ioni)]TJ /Span<>> BDC ( )Tj EMC 3.934 0 Td [(A, )0.6(F)10(r)-33(anza)]TJ /Span<>> BDC ( )Tj EMC 4.602 0 Td [(L, )0.6(Br)-36.9(igid)42(a)]TJ /Span<>> BDC ( )Tj EMC 4.748 0 Td [(M, )0.6(e)-12(t)]TJ /Span<>> BDC ( )Tj EMC 2.89 0 Td [(al. )0.5(Gut )0.5(micr)-32(obio)17(t)15(a )0.6(and)7( )]TJ 0.005 Tc 0.349 Tw -17.491 -1.25 Td [(a)-16.7(cute di)-15.6(ver)-21.7(t)-31.7(icul)-30.6(i)-23.7(t)-31.6(is: r)-31.6(ole of p)25.3(r)-31.6(obio)17.3(t)-31.7(ics in mana)-16.7(gement of t)-12.7(his)5( )]TJ 0 Tc 0.228 Tw T* [(del)-31(ica)15(te p)32(a)15(t)-13(hophy)-13(siol)30(o)-16(gical bal)-15.9(ance. )]TJ /T1_1 1 Tf [(J P)15(ers Med.)]TJ /T1_0 1 Tf ( 2021;11\(4\):298. )Tj 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.3390/jpm11040298)Tj 0 0 0 1 k /GS1 gs 0.044 Tw -1.847 -1.25 Td (8.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(M)-24(oniuszko)]TJ /Span<>> BDC ( )Tj EMC [(A, R)-20(yd)17(zewsk)-17(a)]TJ /Span<>> BDC ( )Tj EMC [(G. T)47(he ef)-56(fec)-15.9(t of cycl)-31(ic r)-37(if)16(aximin t)-13(her)-33(apy )]TJ 0.002 Tw -1.296 -1.25 Td [(on )0.5(sym)10(pt)17(oms )0.5(of )0.5(di)-16(ver)-22(t)-32(icul)-15.9(ar )0.5(disease )0.5(fr)-32(om )0.5(t)-13(he )0.5(per)-10(spec)-16(t)-31.9(i)-16(ve )0.5(of )0.5(t)-13(he )0.5(gas)]TJ 0 Tw (-)Tj -0.02 Tw T* [(tr)-32(oenter)-31.9(ol)30(o)-16(g)16(y )0.5(outp)32(a)15(t)-32(ient )0.6(cl)-31(inic: )0.6(a )0.5(\231r)-24(eal-l)-30.9(ife\232 )0.5(stud)17.1(y. )]TJ /T1_1 1 Tf 20.621 0 Td [(Pr)-16(z )0.6(Gastroenterol. )]TJ /T1_0 1 Tf 0.023 Tw -20.621 -1.25 Td [(2017;12\(2\):145\22651. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.5114/pg.2017.68167)Tj 0 0 0 1 k /GS1 gs 0.118 Tw T* (9.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Y)50(ar)-22(ull)-30.9(ina)]TJ /Span<>> BDC ( )Tj EMC [(DR, S)-16(haf)-28(igull)-30.9(in)]TJ /Span<>> BDC ( )Tj EMC [(MU, Sakul)-30.9(in)]TJ /Span<>> BDC ( )Tj EMC [(KA, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Char)-32.9(a)-17(c)-16(ter)-37(iza)15(t)-32(ion )]TJ 0.094 Tw -1.296 -1.25 Td [(of gut contr)-33(a)-17(c)-16(t)-32(il)-30.9(i)-24(t)-10(y and micr)-31.9(obio)17(t)15(a in p)32(a)15(t)-32(ients )0.5(wi)-24(t)-13(h sever)-23.9(e chr)-32(onic )]TJ 0 Tw T* [(const)-32(ip)32(a)15(t)-32(ion. )]TJ /T1_1 1 Tf 0.184 Tw 5.821 0 Td (PLoS ONE.)Tj /T1_0 1 Tf [( 2020;15\(7\):e0235985. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1371/jour)Tj 21.465 0 Td (-)Tj -27.286 -1.25 Td (nal.pone.0235985)Tj 0 0 0 1 k /GS1 gs 0.16 Tw T* (10.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(W)22(edel)]TJ /Span<>> BDC ( )Tj EMC [(T, Bar)-24(r)-23.9(enschee)]TJ /Span<>> BDC ( )Tj EMC [(M, L)-32(ange)]TJ /Span<>> BDC ( )Tj EMC [(C, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. M)-24(or)-23.9(phol)30(o)-16(gic basis for )]TJ -0.042 Tw -1.796 -1.25 Td [(devel)30(oping di)-16(ver)-22(t)-32(icul)-15.9(ar disease, di)-16(ver)-21.9(t)-32(icul)-31(i)-23.9(t)-32(is, and di)-16(ver)-22(t)-32(icul)-15.9(ar bleed)]TJ 0 Tw (-)Tj T* (ing. )Tj /T1_1 1 Tf 1.85 0 Td (Viszeralmedizin.)Tj /T1_0 1 Tf 0.023 Tw [( 2015;31\(2\):76\22682. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1159/000381431)Tj 0 0 0 1 k /GS1 gs 0.099 Tw -1.85 -1.25 Td (11.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(S)-16(he)-12(t)-13(h)]TJ /Span<>> BDC ( )Tj EMC [(A, Fl)30(o)-16(ch)]TJ /Span<>> BDC ( )Tj EMC [(M. P)35(r)-32(obio)17(t)-32(ics and di)-16(ver)-22(t)-32(icul)-15.9(ar disease. )]TJ /T1_1 1 Tf [(N)21(utr Clin )]TJ 0 Tw -1.796 -1.25 Td (Pract.)Tj /T1_0 1 Tf 0.023 Tw [( 2009;24\(1\):41\2264. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1177/0884533608329230)Tj 0 0 0 1 k /GS1 gs 0.049 Tw T* (12.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Sek)-16(ir)-32(ov)]TJ /Span<>> BDC ( )Tj EMC (I, Russell)Tj /Span<>> BDC ( )Tj EMC (SL, Antunes)Tj /Span<>> BDC ( )Tj EMC [(L)35(C, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Gut micr)-31.9(obio)17(t)15(a in heal)56(t)-13(h )]TJ 0.136 Tw -1.796 -1.25 Td (and disease. )Tj /T1_1 1 Tf [(Ph)12(ysiol R)21(ev.)]TJ /T1_0 1 Tf [( 2010;90\(3\):859\226904. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw [(10.1152/phy)-12.9(s)]TJ (-)Tj T* [(r)-24(ev.00045.2009)]TJ 0 0 0 1 k /GS1 gs -0.034 Tw T* (13.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Di P)-24(ier)-24(r)-31.9(o)]TJ /Span<>> BDC ( )Tj EMC [(F. Gut micr)-31.9(obio)17(t)15(a p)32(ar)-33(ame)-12(ter)-10(s po)17(tent)-32(iall)35.1(y useful in cl)-31(ini)]TJ 0 Tw (-)Tj 0.307 Tw -1.796 -1.25 Td [(cal per)-10(spec)-16(t)-31.9(i)-16(ve. )]TJ /T1_1 1 Tf 0 Tw [(Microorg)12.1(anis)33(ms.)]TJ /T1_0 1 Tf 0.307 Tw [( 2021;9\(11\):2402. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.3390/)Tj T* [(micr)-32(o)-16(or)-31.9(ganis)26(ms9112402)]TJ 0 0 0 1 k /GS1 gs 0.132 Tw T* [(1)66(4.)]TJ /Span<>> BDC ( )Tj EMC 1.73 0 Td [(L)35(e)-11(y)]TJ /Span<>> BDC ( )Tj EMC 1.696 0 Td [(RE, )0.5(T)60(ur)-15(nbaugh)]TJ /Span<>> BDC ( )Tj EMC [(P)35.1(J, )0.5(Klein)]TJ /Span<>> BDC ( )Tj EMC 10.075 0 Td [(S, )0.5(e)-12(t)]TJ /Span<>> BDC ( )Tj EMC 2.208 0 Td [(al. )0.5(Micr)-32(obial )0.6(ecol)30(o)-16(g)16(y)28(: )0.5(human )]TJ -0.013 Tw -15.709 -1.25 Td (gut)Tj /Span<>> BDC ( )Tj EMC [(micr)-31.9(obes asso)-16(c)-23.9(ia)15(ted wi)-24(t)-13(h obesi)-24(t)-10(y)]TJ /T1_1 1 Tf [(. N)18(ature.)]TJ /T1_0 1 Tf [( 2)19.9(0)-16(06;4)13(4)13(4\(7)136(1)72(2)25(2\):1)45(0)25(2)25(2\226)]TJ 0.023 Tw T* [(3)31(. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs -0.045 Tc 0.045 Tw [(10)-30(.10)-21.1(3)-30(8)-45(/)-5(4)-32(4)-32(4)62(10)-20(2)-20(2)-45(a)]TJ 0 0 0 1 k /GS1 gs 0 Tc 0.044 Tw T* (15.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(P)40(ascale)]TJ /Span<>> BDC ( )Tj EMC [(A, Mar)-31.9(chesi)]TJ /Span<>> BDC ( )Tj EMC [(N, Mar)-24(ell)-30.9(i)]TJ /Span<>> BDC ( )Tj EMC [(C, e)-11.9(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Micr)-32(obio)17(t)15(a and me)-12(t)15(abol)-31(ic )]TJ 0.004 Tc -0.004 Tw -1.796 -1.25 Td (diseases. )Tj /T1_1 1 Tf 4.257 0 Td [(Endocr)-36.6(ine.)]TJ /T1_0 1 Tf 0.349 Tw [( 2018;61\(3)0.5(\):357\226371. d)-15.5(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs -0.004 Tw [(10.1007/s)0.5(12020-)]TJ 0 Tc 0 Tw -4.257 -1.25 Td (018-1605-5)Tj 0 0 0 1 k /GS1 gs 0.241 Tw T* (16.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Duan)Tj /Span<>> BDC ( )Tj EMC (R, Zhu)Tj /Span<>> BDC ( )Tj EMC [(S, W)12(ang)]TJ /Span<>> BDC ( )Tj EMC [(B, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Al)56.1(ter)-33(a)15(t)-32(ions of gut micr)-32(obio)17(t)15.1(a )]TJ 0.21 Tw 27.259 62.5 Td [(in p)32(a)15(t)-32(ients wi)-23.9(t)-13(h ir)-24(r)-36.9(i)-24(t)15(able bo)-14(wel syndr)-31.9(ome based on 16s r)-24(r)-15(na-t)15(ar)]TJ 0 Tw 27.286 0 Td (-)Tj 0.244 Tw -27.286 -1.25 Td [(ge)-12(ted sequenc)-24(ing: A sy)-13(stema)15(t)-32(ic r)-24(ev)-16(iew. )]TJ /T1_1 1 Tf [(Clin T)56(ransl Gastroenterol)]TJ /T1_0 1 Tf 0 Tw (. )Tj 0.023 Tw T* [(2019;10\(2\):e00012. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw [(10.14309/c)-16(tg.0000000000000012)]TJ 0 0 0 1 k /GS1 gs 0.116 Tw T* (17.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(L)-32(inninge)]TJ /Span<>> BDC ( )Tj EMC [(C, R)11(o)17(t)-13(h)]TJ /Span<>> BDC ( )Tj EMC [(B, Er)-30(l)-16(anson-Alber)-21.9(tsson)]TJ /Span<>> BDC ( )Tj EMC [(C, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. A)-14(bund)42(ance of )]TJ /T1_1 1 Tf 0 Tw -1.796 -1.25 Td [(Enterobacter)-36.9(iaceae )]TJ /T1_0 1 Tf -0.008 Tw 7.757 0 Td [(in t)-12.9(he col)30(on mucosa in di)-16(ver)-21.9(t)-32(icul)-16(ar disease. )]TJ /T1_1 1 Tf 0 Tw [(W)29(orld )]TJ 0.245 Tw -7.757 -1.25 Td [(J Gastrointest )0.5(P)18(athoph)12(ysiol.)]TJ /T1_0 1 Tf [( 2018;9\(1\):18\22627. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.4291/wjgp.)Tj T* (v9.i1.18)Tj 0 0 0 1 k /GS1 gs -0.013 Tw T* (18.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Ang)Tj /Span<>> BDC ( )Tj EMC [(MY, Dymo)-16(ck)]TJ /Span<>> BDC ( )Tj EMC [(D, T)40(an)]TJ /Span<>> BDC ( )Tj EMC [(JL, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC (al. Genome sequence of )Tj /T1_1 1 Tf 0 Tw [(P)18(ar)-42(vimonas )]TJ -1.796 -1.25 Td (micra)Tj /T1_0 1 Tf -0.004 Tw [( str)-32.9(ain A293, isol)-16(a)15(ted fr)-31.9(om an abd)-16(ominal abscess fr)-32(om a p)32(a)15(t)-32(ient )]TJ 0.257 Tw T* [(in t)-12.9(he U)13(ni)-24(ted Kingd)-16(om. )]TJ /T1_1 1 Tf (Genome Announc.)Tj /T1_0 1 Tf ( 2013;1\(6\):e01025\22613. )Tj 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1128/genomeA.01025-13)Tj 0 0 0 1 k /GS1 gs 0.003 Tc 0.35 Tw -1.847 -1.25 Td (19.)Tj /Span<>> BDC ( )Tj EMC 1.808 0 Td [(W)12(ang)]TJ /Span<>> BDC ( )Tj EMC 2.772 0 Td [(Q, )0.5(Huang )0.5(S-Q, )0.5(L)-32(i )0.5(C-Q, )0.5(e)-12(t)]TJ /Span<>> BDC ( )Tj EMC 11.625 0 Td (al. )Tj /T1_1 1 Tf 1.613 0 Td [(Akk)17(er)-14(mansia )0.5(muciniphi)]TJ 0 Tc 0 Tw (-)Tj -17.817 -1.25 Td (la)Tj /T1_0 1 Tf 0.298 Tw [( ma)15(y de)-12(ter)-15.9(mine chondr)-32(oi)-24(t)-32(in sulf)16.1(a)15(te amel)-31(ior)-32.9(a)15(t)-32(ing or a)-17(ggr)-33(av)-15(a)15(t)]TJ 0 Tw (-)Tj 0.005 Tc 0.349 Tw T* [(ing osteoar)-21.7(t)-12.7(hr)-36.8(i)-23.7(t)-31.7(is. )]TJ /T1_1 1 Tf [(F)27.2(ront Microbiol.)]TJ /T1_0 1 Tf [( 2017;8:1955. d)-15.8(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs -0.005 Tw (10.3389/)Tj 0 Tc 0 Tw T* (fmicb.2017.01955)Tj 0 0 0 1 k /GS1 gs 0.177 Tw T* (20.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Chen)Tj /Span<>> BDC ( )Tj EMC (J, Chen)Tj /Span<>> BDC ( )Tj EMC (X, Ho)Tj /Span<>> BDC ( )Tj EMC [(CL. R)13(ecent devel)30(opment of p)25(r)-32(obio)17.1(t)-32(ic bif)-28(i)]TJ 0 Tw (-)Tj 0.231 Tw -1.796 -1.25 Td [(d)-16(oba)-17(c)-16(ter)-36.9(ia for tr)-24(ea)15(t)-32(ing human diseases. )]TJ /T1_1 1 Tf [(F)27(ront Bioeng Bio)13.1(technol.)]TJ /T1_0 1 Tf 0 Tw ( )Tj 0.023 Tw T* [(2021;9:770248. d)-15.9(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.3389/fbioe.2021.770248)Tj 0 0 0 1 k /GS1 gs 0.341 Tw T* (21.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Gueimonde)Tj /Span<>> BDC ( )Tj EMC (M, Ouwehand)Tj /Span<>> BDC ( )Tj EMC [(A, Huht)-32(inen)]TJ /Span<>> BDC ( )Tj EMC [(H, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Q)-16(ual)-30.9(i)-24(t)15(a)15(t)-32(i)-16(ve )]TJ 0.149 Tw -1.796 -1.25 Td [(and quant)-31.9(i)-24(t)15(a)15(t)-32(i)-16(ve anal)35(y)-13(ses of t)-13(he bif)-27.9(id)-16(oba)-17(c)-16(ter)-37(ial micr)-32(obio)17(t)15(a in t)-13(he )]TJ 0.016 Tw T* [(col)30(onic mucosa of p)32(a)15(t)-32(ients wi)-24(t)-12.9(h col)30(or)-23.9(ec)-16(t)15(al cancer, di)-15.9(ver)-22(t)-32(icul)-30.9(i)-24(t)-32(is, and )]TJ 0.021 Tw T* [(infl)-15.9(amma)15(t)17(or)-24(y bo)-14(wel disease. )]TJ /T1_1 1 Tf [(W)29(orld J Gastroenterol.)]TJ /T1_0 1 Tf ( 2007;13:3985\2269. )Tj 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.3748/wjg.v13.i29.3985)Tj 0 0 0 1 k /GS1 gs 0.182 Tw -1.847 -1.25 Td (22.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(K)20(v)-15(asnovsk)-31.9(y)]TJ /Span<>> BDC ( )Tj EMC 4.999 0 Td [(CL, )0.5(L)35(eong)]TJ /Span<>> BDC ( )Tj EMC 4.32 0 Td [(LEX, )0.6(Cho)-16(o)]TJ /Span<>> BDC ( )Tj EMC [(JM, )0.5(e)-12(t)]TJ /Span<>> BDC ( )Tj EMC 7.387 0 Td [(al. )0.5(Cl)-30.9(inical )0.5(and )0.5(sym)10(p)]TJ 0 Tw (-)Tj 0.197 Tw -18.502 -1.25 Td [(t)17(om scor)-23.9(es ar)-24(e signif)-28(icantl)35.1(y cor)-24(r)-24(el)-15.9(a)15(ted wi)-24(t)-13(h fecal micr)-32(obio)17(t)15(a fea)]TJ 0 Tw (-)Tj 0.006 Tc 0.349 Tw T* [(t)0.5(u)0.5(r)-23.5(e)0.5(s)0.5( i)0.5(n)0.5( p)32.5(a)15.5(t)-31.5(i)0.5(e)0.5(n)0.5(t)0.5(s)0.5( w)0.5(i)-23.5(t)-12.4(h s)0.5(y)0.5(m)10.5(pt)17.5(o)0.5(m)0.5(a)15.5(t)-31.5(i)0.5(c)0.5( u)0.5(n)0.5(c)0.5(o)0.5(m)10.5(p)0.5(l)-30.5(i)0.5(c)0.5(a)15.5(t)0.5(e)0.5(d)0.5( d)0.5(i)-15.5(v)0.5(e)0.5(r)-21.5(t)-31.5(i)0.5(c)0.5(u)0.5(l)-15.5(a)0.5(r)6( )]TJ 0 Tc 0.045 Tw T* [(disease: A pil)30(o)17(t stud)17(y. )]TJ /T1_1 1 Tf (Eur J Gastroenterol Hepatol.)Tj /T1_0 1 Tf ( 2018;30:107\22612. )Tj 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1097/MEG.0000000000000995)Tj 0 0 0 1 k /GS1 gs 0.011 Tc 0.394 Tw -1.847 -1.25 Td (23.)Tj /Span<>> BDC ( )Tj EMC 1.838 0 Td [(Bar)-23.6(b)0.5(ar)-32.6(a)]TJ /Span<>> BDC ( )Tj EMC [(G, S)-23.6(caiol)-30.6(i)]TJ /Span<>> BDC 8.024 0 Td ( )Tj EMC [(E, Bar)-23.6(bar)-31.5(o)]TJ /Span<>> BDC ( )Tj EMC [(M)0.5(R, e)-11.6(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Gut micr)-31.5(obio)17.4(t)15.4(a,)11( )]TJ 0 Tc 0.308 Tw -9.863 -1.25 Td [(me)-12(t)15(abol)30(ome )0.6(and )0.6(immune )0.5(signa)15.1(tur)-24(es )0.6(in )0.5(p)32(a)15(t)-31.9(ients )0.5(wi)-23.9(t)-13(h )0.5(uncom)10.1(pl)-31(i)]TJ 0 Tw (-)Tj 0.067 Tw T* [(ca)15(ted di)-16(ver)-22(t)-32(icul)-15.9(ar disease. )]TJ /T1_1 1 Tf 0 Tw (Gut)Tj /T1_0 1 Tf 0.067 Tw [(. 2017;66\(7\):1252\22661. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1136/)Tj T* (gutjnl-2016-312377)Tj 0 0 0 1 k /GS1 gs 0.017 Tc 0.605 Tw T* (24.)Tj /Span<>> BDC ( )Tj EMC 1.862 0 Td [(F)20.4(al)-15.6(a)-16.7(gas)]TJ /Span<>> BDC ( )Tj EMC 3.947 0 Td [(ME, S)-15.6(iak)-16.6(avell)-15.6(as)]TJ /Span<>> BDC ( )Tj EMC (E. )Tj /T1_1 1 Tf 9.388 0 Td [(Bacteroides, )0.5(Prev)13.3(o)13.4(tella)]TJ /T1_0 1 Tf [(, )0.5(and)17( )]TJ /T1_1 1 Tf 0.01 Tc -0.01 Tw -15.198 -1.25 Td [(P)15(or)-18.1(ph)12(yromonas)]TJ /T1_0 1 Tf 0.374 Tw [( spec)-24(ies: a r)-24(ev)-16(iew of ant)-32(ibio)17(t)-32(ic r)-24(esist)14.9(ance and)10( )]TJ 0.008 Tc 0.35 Tw T* [(t)-13.4(her)-33.4(apeut)-32.4(ic opt)-32.4(ions. )]TJ /T1_1 1 Tf [(Int J Antimicrob A)10.6(g)11.5(ents)]TJ /T1_0 1 Tf [(. 2000;15\(1\):1\2269.)8( )]TJ 0 Tc 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1016/s0924-8579\(99\)00164-8)Tj 0 0 0 1 k /GS1 gs -0.002 Tw -1.847 -1.25 Td (25.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Ar)-22(umugam)]TJ /Span<>> BDC ( )Tj EMC [(M, R)-10(aes)]TJ /Span<>> BDC ( )Tj EMC [(J, P)30(elle)-12(t)-31.9(ier)]TJ /Span<>> BDC ( )Tj EMC [(E, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Enter)-31.9(o)17(t)-10(ypes of t)-13(he human )]TJ 0.322 Tw -1.796 -1.25 Td [(gut micr)-31.9(obiome. )]TJ /T1_1 1 Tf 0 Tw [(N)18(ature)]TJ /T1_0 1 Tf 0.322 Tw [(. )0.5(2011;473\(7346\):174\22680. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1038/)Tj T* [(na)15(tur)-23.9(e09944)]TJ 0 0 0 1 k /GS1 gs 0.018 Tw T* (26.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(W)16(u)]TJ /Span<>> BDC ( )Tj EMC (GD, Chen)Tj /Span<>> BDC ( )Tj EMC [(J, Hof)-56(fmann)]TJ /Span<>> BDC ( )Tj EMC [(C, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. L)-32(ink)-16(ing l)30(ong-ter)-15.9(m die)-12(t)15(ar)-24(y p)32(a)15(t)]TJ 0 Tw (-)Tj 0.003 Tw -1.796 -1.25 Td [(ter)-15(ns wi)-23.9(t)-13(h gut micr)-32(obial enter)-32(o)17(t)-9.9(ypes. )]TJ /T1_1 1 Tf 0 Tw (Science)Tj /T1_0 1 Tf 0.003 Tw (. 2011;334\(6052\):105\226)Tj 0.023 Tw T* [(8. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw [(10.1126/sc)-24(ience.1208344)]TJ 0 0 0 1 k /GS1 gs 0.323 Tw T* (27.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(K)25(oe)-12(t)-13(h)]TJ /Span<>> BDC ( )Tj EMC 2.912 0 Td [(RA, )0.5(W)12(ang)]TJ /Span<>> BDC ( )Tj EMC 4.551 0 Td [(Z, )0.5(L)35(ev)-16(ison)]TJ /Span<>> BDC ( )Tj EMC [(BS, )0.5(e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. )0.5(Intest)-32(inal )0.5(micr)-32(obio)17(t)15(a )]TJ 0.062 Tw -9.259 -1.25 Td [(me)-12(t)15(abol)-30.9(is)26(m of L-car)-15(ni)-23.9(t)-32(ine, a nutr)-36.9(ient in r)-23.9(ed mea)15(t, p)25(r)-32(omo)17(tes a)15(t)-13(her)-31.9(o)]TJ 0 Tw (-)Tj T* [(scler)-31.9(osis. )]TJ /T1_1 1 Tf 0.023 Tw 4.008 0 Td [(N)18(at Med.)]TJ /T1_0 1 Tf [( 2013;19\(5\):576\22685. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1038/nm.3145)Tj 0 0 0 1 k /GS1 gs 0.154 Tw -4.008 -1.25 Td (28.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(R)11(oa)-17(ger)]TJ /Span<>> BDC ( )Tj EMC [(HM, L)-32(icht)]TJ /Span<>> BDC ( )Tj EMC [(TR, P)10(oulsen)]TJ /Span<>> BDC ( )Tj EMC [(SK, e)-11.9(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Micr)-32(obial enter)-32(o)17(t)-10(ypes, )]TJ 0.005 Tc 0.35 Tw -1.796 -1.25 Td [(infer)-24.3(r)-24.3(ed b)11.7(y t)-13.3(he )]TJ /T1_1 1 Tf -0.005 Tw [(Prev)12.6(o)12.7(tella)]TJ /T1_0 1 Tf [(-t)16.6(o-)]TJ /T1_1 1 Tf (Bacteroides)Tj /T1_0 1 Tf 0.35 Tw [( r)-33.3(a)14.6(t)-32.3(io, r)-24.3(emained st)14.6(able)5.1( )]TJ 0 Tc 0.289 Tw T* [(dur)-37(ing a 6-mont)-12.9(h r)-33(and)-16(omized contr)-32(olled die)-12(t inter)-32(vent)-31.9(ion wi)-24(t)-13(h )]TJ 0.261 Tw T* [(t)-13(he )0.6(new )0.6(nor)-24(dic )0.6(die)-12(t. )]TJ /T1_1 1 Tf 9.421 0 Td [(Appl )0.6(En)11(viron )0.6(Microbiol.)]TJ /T1_0 1 Tf [( )0.5(2014;80\(3\):1142\2269. )]TJ 0 Tw -9.421 -1.25 Td [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1128/AEM.03549-13)Tj /T1_3 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\033\030\031\030\213\b)-20.9(\035\231\213\233\t \021\032)50(\b)42(\032\231\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj -51.938 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 23, \023\0221)69(, 202)69(4)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 23, \023\0221)69(, 202)69(4)]TJ /T1_4 1 Tf 25 0 0 25 19.9401 56.0378 Tm (116)Tj ET endstream endobj 1221 0 obj <>/Border[0 0 0]/H/N/Rect[262.057 718.512 291.968 709.056]/Subtype/Link/Type/Annot>> endobj 1222 0 obj <>/Border[0 0 0]/H/N/Rect[70.8661 708.512 135.914 699.216]/Subtype/Link/Type/Annot>> endobj 1223 0 obj <>/Border[0 0 0]/H/N/Rect[85.6442 668.512 194.22 659.216]/Subtype/Link/Type/Annot>> endobj 1224 0 obj <>/Border[0 0 0]/H/N/Rect[262.057 648.512 291.968 639.056]/Subtype/Link/Type/Annot>> endobj 1225 0 obj <>/Border[0 0 0]/H/N/Rect[70.8661 638.512 112.01 629.216]/Subtype/Link/Type/Annot>> endobj 1226 0 obj <>/Border[0 0 0]/H/N/Rect[326.503 718.512 410.935 709.216]/Subtype/Link/Type/Annot>> endobj 1227 0 obj <>/Border[0 0 0]/H/N/Rect[447.813 688.512 506.013 679.056]/Subtype/Link/Type/Annot>> endobj 1228 0 obj <>/Border[0 0 0]/H/N/Rect[318.085 638.512 394.813 629.216]/Subtype/Link/Type/Annot>> endobj 1229 0 obj <>/Border[0 0 0]/H/N/Rect[85.6442 577.511 178.5 568.215]/Subtype/Link/Type/Annot>> endobj 1230 0 obj <>/Border[0 0 0]/H/N/Rect[262.057 557.511 291.968 548.055]/Subtype/Link/Type/Annot>> endobj 1231 0 obj <>/Border[0 0 0]/H/N/Rect[70.8661 547.511 105.842 538.215]/Subtype/Link/Type/Annot>> endobj 1232 0 obj <>/Border[0 0 0]/H/N/Rect[142.918 507.511 235.774 498.215]/Subtype/Link/Type/Annot>> endobj 1233 0 obj <>/Border[0 0 0]/H/N/Rect[190.793 477.511 291.968 468.215]/Subtype/Link/Type/Annot>> endobj 1234 0 obj <>/Border[0 0 0]/H/N/Rect[70.8661 467.511 96.498 458.215]/Subtype/Link/Type/Annot>> endobj 1235 0 obj <>/Border[0 0 0]/H/N/Rect[168.638 437.511 265.662 428.055]/Subtype/Link/Type/Annot>> endobj 1236 0 obj <>/Border[0 0 0]/H/N/Rect[140.838 397.511 238.31 388.215]/Subtype/Link/Type/Annot>> endobj 1237 0 obj <>/Border[0 0 0]/H/N/Rect[85.6442 357.511 159.572 348.215]/Subtype/Link/Type/Annot>> endobj 1238 0 obj <>/Border[0 0 0]/H/N/Rect[153.286 317.511 231.95 308.215]/Subtype/Link/Type/Annot>> endobj 1239 0 obj <>/Border[0 0 0]/H/N/Rect[246.545 287.511 291.968 278.055]/Subtype/Link/Type/Annot>> endobj 1240 0 obj <>/Border[0 0 0]/H/N/Rect[70.8661 277.511 129.434 268.215]/Subtype/Link/Type/Annot>> endobj 1241 0 obj <>/Border[0 0 0]/H/N/Rect[217.161 247.511 283.073 238.055]/Subtype/Link/Type/Annot>> endobj 1242 0 obj <>/Border[0 0 0]/H/N/Rect[165.984 227.511 259.896 218.055]/Subtype/Link/Type/Annot>> endobj 1243 0 obj <>/Border[0 0 0]/H/N/Rect[244.297 207.511 291.968 198.055]/Subtype/Link/Type/Annot>> endobj 1244 0 obj <>/Border[0 0 0]/H/N/Rect[70.8661 197.511 121.602 188.215]/Subtype/Link/Type/Annot>> endobj 1245 0 obj <>/Border[0 0 0]/H/N/Rect[262.057 177.511 291.968 168.055]/Subtype/Link/Type/Annot>> endobj 1246 0 obj <>/Border[0 0 0]/H/N/Rect[70.8661 167.511 149.913 158.215]/Subtype/Link/Type/Annot>> endobj 1247 0 obj <>/Border[0 0 0]/H/N/Rect[93.8145 137.511 151.775 128.215]/Subtype/Link/Type/Annot>> endobj 1248 0 obj <>/Border[0 0 0]/H/N/Rect[235.725 117.511 291.968 108.055]/Subtype/Link/Type/Annot>> endobj 1249 0 obj <>/Border[0 0 0]/H/N/Rect[70.8661 107.511 108.498 98.2152]/Subtype/Link/Type/Annot>> endobj 1250 0 obj <>/Border[0 0 0]/H/N/Rect[385.015 577.511 495.735 568.215]/Subtype/Link/Type/Annot>> endobj 1251 0 obj <>/Border[0 0 0]/H/N/Rect[476.842 547.511 524.409 538.055]/Subtype/Link/Type/Annot>> endobj 1252 0 obj <>/Border[0 0 0]/H/N/Rect[303.307 537.511 329.827 528.215]/Subtype/Link/Type/Annot>> endobj 1253 0 obj <>/Border[0 0 0]/H/N/Rect[318.085 497.511 411.005 488.215]/Subtype/Link/Type/Annot>> endobj 1254 0 obj <>/Border[0 0 0]/H/N/Rect[494.232 467.511 524.409 458.055]/Subtype/Link/Type/Annot>> endobj 1255 0 obj <>/Border[0 0 0]/H/N/Rect[303.307 457.511 362.059 448.215]/Subtype/Link/Type/Annot>> endobj 1256 0 obj <>/Border[0 0 0]/H/N/Rect[371.359 427.511 462.495 418.215]/Subtype/Link/Type/Annot>> endobj 1257 0 obj <>/Border[0 0 0]/H/N/Rect[318.085 377.511 404.156 368.215]/Subtype/Link/Type/Annot>> endobj 1258 0 obj <>/Border[0 0 0]/H/N/Rect[318.085 327.511 427.861 318.215]/Subtype/Link/Type/Annot>> endobj 1259 0 obj <>/Border[0 0 0]/H/N/Rect[494.498 297.511 524.409 288.055]/Subtype/Link/Type/Annot>> endobj 1260 0 obj <>/Border[0 0 0]/H/N/Rect[303.307 287.511 368.355 278.215]/Subtype/Link/Type/Annot>> endobj 1261 0 obj <>/Border[0 0 0]/H/N/Rect[318.085 247.511 426.661 238.215]/Subtype/Link/Type/Annot>> endobj 1262 0 obj <>/Border[0 0 0]/H/N/Rect[494.498 227.511 524.409 218.055]/Subtype/Link/Type/Annot>> endobj 1263 0 obj <>/Border[0 0 0]/H/N/Rect[303.307 217.511 344.451 208.215]/Subtype/Link/Type/Annot>> endobj 1264 0 obj <>/Border[0 0 0]/H/N/Rect[326.503 187.511 410.935 178.215]/Subtype/Link/Type/Annot>> endobj 1265 0 obj <>/Border[0 0 0]/H/N/Rect[447.813 157.511 506.013 148.055]/Subtype/Link/Type/Annot>> endobj 1266 0 obj <>/Border[0 0 0]/H/N/Rect[318.085 107.511 394.813 98.2152]/Subtype/Link/Type/Annot>> endobj 1312 0 obj <> endobj 1311 0 obj <> endobj 1310 0 obj <> endobj 1309 0 obj <> endobj 1308 0 obj <> endobj 1307 0 obj <> endobj 1306 0 obj <> endobj 1305 0 obj <> endobj 1304 0 obj <> endobj 1303 0 obj <> endobj 1302 0 obj <> endobj 1301 0 obj <> endobj 1300 0 obj <> endobj 1299 0 obj <> endobj 1298 0 obj <> endobj 1297 0 obj <> endobj 1296 0 obj <> endobj 1295 0 obj <> endobj 1294 0 obj <> endobj 1293 0 obj <> endobj 1292 0 obj <> endobj 1291 0 obj <> endobj 1290 0 obj <> endobj 1289 0 obj <> endobj 1288 0 obj <> endobj 1287 0 obj <> endobj 1286 0 obj <> endobj 1285 0 obj <> endobj 1284 0 obj <> endobj 1283 0 obj <> endobj 1282 0 obj <> endobj 1281 0 obj <> endobj 1280 0 obj <> endobj 1279 0 obj <> endobj 1278 0 obj <> endobj 1277 0 obj <> endobj 1276 0 obj <> endobj 1275 0 obj <> endobj 1274 0 obj <> endobj 1273 0 obj <> endobj 1272 0 obj <> endobj 1271 0 obj <> endobj 1270 0 obj <> endobj 1269 0 obj <> endobj 1268 0 obj <> endobj 1267 0 obj <> endobj 1174 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1175 0 obj <>/Font<>/ProcSet[/PDF/Text/ImageC]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1176 0 obj <>/Font<>/ProcSet[/PDF/Text/ImageC]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1177 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1178 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1319 0 obj [1321 0 R 1322 0 R 1323 0 R 1324 0 R 1325 0 R 1326 0 R 1327 0 R 1328 0 R 1329 0 R 1330 0 R 1331 0 R 1332 0 R 1333 0 R 1334 0 R 1335 0 R 1336 0 R 1337 0 R 1338 0 R 1339 0 R 1340 0 R 1341 0 R 1342 0 R 1343 0 R 1344 0 R 1345 0 R 1346 0 R 1347 0 R 1348 0 R 1349 0 R] endobj 1320 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\034\002\220\006)-10(\026)11(\016\001\025\017\001\013\205 \024\220\n\002\025\f\220\025\026)11(\013 \201\220\r\016\002\026\220\n\215\007\025\r \221\002\220\022\r\025\006\ \221\013\007\220\026)11(\016\007\216\001\020\207 )]TJ 0 -1 TD [(\025\006)-10(\007\025\217\001\016\001\220\205\207 \201\220\r\016\002\026\220\n\215\007\ \205\002\001\025\203 \f\025\007\016\222\001\220 \(\221\220\007\025\026\001\ \025\016 \220\006\006)-10(\007\016\201\025\r\013\001\220\016\))]TJ 39.309 1 Td [(Mucosal micr)20(obiota of th)11(e div)12(er)-20(ticula in inflammator)-31(y )]TJ 1.089 -1 Td [(complications of div)12(er)-19.9(ticular disease \(a pilot study\))]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0.598 Tw 10 0 0 10 42.5197 724.8299 Tm [(\024\021\007\036\035\036\027\017\016 )0.6(\022\024\035\024\023\030\024\022\021\024\035\024\020\017\017 )0.6(\217\025\207 )0.5(\204\003 )0.5(\217\230; )0.6(ORCID )]TJ 0 Tw 0 -1.218 TD (0000-0001-8344-2696)Tj 0.195 Tw T* (\215\026\027\022\030\026\021\024\r\026 \236\035\017\016 \221\036\030\020\ \036\036\r\027\026)Tj /Span<>> BDC ( )Tj EMC (\227 \026\f\f\017\f\021\036\027\021 \022\026\235\036\007\030\t )Tj 0.163 Tw T* [(\b\017\030\031\030\020\017\004\036\f\022\017\b )0.6(\002\024\035\036\027\036\005 )0.5(\025\206\204\211, )0.6(\r\030\026\004 )0.5(\b\017\030\031\030\020 )0.5(\024\021\007\036\035\036)]TJ 0 Tw (-)Tj T* (\027\017\016 \b\017\030\031\030\020\017\017 \2251; ORCID 0000-0001-7498-\ 2412)Tj 0.049 Tw T* (\221\036\027\017\027\026 \202\027\026\f\021\026\f\017\016 \204\017\b\026\ \005\035\024\r\027\026)Tj /Span<>> BDC ( )Tj EMC (\227 \026\f\023\017\030\026\027\021, \027\026\031\004\027\t\005 )Tj 0.058 Tw 0 -1.218 TD [(\f\024\021\030\031\007\027\017\022 \203\222\214 \253\204\031\035\034\021\ \017\024\n\017\022\f\027\t\036 )0.5(\021\036\b\027\024\035\024\020\017\017 \032\017\r\t\b )]TJ 0 Tw 0 -1.218 TD (\f\017\f\021\036\n\273 \025\205\211; ORCID 0000-0002-9491-1694)Tj 0.312 Tw T* (\207\031\035\t\020\017\027\026 \213\r\020\036\027\017\016 \202\035\036\022\ \f\026\027\007\030\024\r\027\026)Tj /Span<>> BDC ( )Tj EMC (\227 \027\026\031\004\027\t\005 \f\024)Tj 0 Tw (-)Tj 0.041 Tw T* (\021\030\031\007\027\017\022 \203\222\214 \253\207\017\024\n\036\007\017\ \006\017\027\f\022\017\036 \030\036\020\036\027\036\030\026\021\017\r\027\ \t\036 \021\036\b)Tj 0 Tw (-)Tj T* (\027\024\035\024\020\017\017\273 \025\205\211; ORCID 0000-0003-3458-1176\ )Tj 0.272 Tw T* (\025\026\030\026\f\036\r\026 \210\035\034\020\026 C\036\030\020\036\036\r\ \027\026)Tj /Span<>> BDC ( )Tj EMC (\227 \n\026\020\017\f\021\030\026\027\021 \022\026\235\036\007\030\t )Tj -0.01 Tw 0 -1.218 TD (\n\017\022\030\024\002\017\024\035\024\020\017\017 \222\027\f\021\017\021\ \031\021\026 \235\031\027\007\026\n\036\027\021\026\035\034\027\024\005 \ \n\036\007\017\006\017)Tj 0 Tw (-)Tj 0 -1.218 TD (\027\t \017)Tj /Span<>> BDC ( )Tj EMC (\002\017\024\035\024\020\017\017 \025\205\211; ORCID 0000-0002-8968-065X\ )Tj 0.226 Tw 0 -1.218 TD (\206\030\017\020\024\030\034\036\r\026 \230\026\021\034\016\027\026 \200\ \035\026\007\017\n\017\030\024\r\027\026)Tj /Span<>> BDC ( )Tj EMC (\227 \r\036\007\031\013\017\005 \027\026)Tj 0 Tw (-)Tj 0.125 Tw T* (\031\004\027\t\005 \f\024\021\030\031\007\027\017\022 \203\222\214 \253\206\ \036\027\036\021\017\022\026 \n\017\022\030\024\024\030\020\026\027\017\ \n\024\r\273 )Tj 0.249 Tw T* (\222\027\f\021\017\021\031\021\026 \235\031\027\007\026\n\036\027\021\026\ \035\034\027\024\005 \n\036\007\017\006\017\027\t \017)Tj /Span<>> BDC ( )Tj EMC (\002\017\024\035\024\020\017\017 )Tj 0 Tw T* (\025\205\211; ORCID 0000-0001-5314-7012)Tj -0.004 Tw 23.244 20.703 Td (\247\030\031\035\035\017\027\026 \212\017\027\026 \217\026\001\017\007\024\ \r\027\026)Tj /Span<>> BDC ( )Tj EMC (\227 \022.\002.\027., \007\024\006\036\027\021 \022\026\235\036\007\030\t\ )Tj -0.01 Tw T* (\n\017\022\030\024\002\017\024\035\024\020\017\017 \222\027\f\021\017\021\ \031\021\026 \235\031\027\007\026\n\036\027\021\026\035\034\027\024\005 \ \n\036\007\017\006\017)Tj 0 Tw (-)Tj T* (\027\t \017)Tj /Span<>> BDC ( )Tj EMC (\002\017\024\035\024\020\017\017 \025\205\211; ORCID 0000-0003-0717-302X\ )Tj 0.299 Tw T* (\025\026\030\023\031\b\017\027 \210\035\036\020 \236\030\034\036\r\017\004\ )Tj /Span<>> BDC ( )Tj EMC (\227 \007.\n.\027., \023\030\024\235\036\f\f\024\030 \022\026)Tj 0 Tw (-)Tj 0.718 Tw T* (\235\036\007\030\t \b\017\030\031\030\020\017\004\036\f\022\017\b \002\024\ \035\036\027\036\005 \025\206\204\211, \022\031\030\026\021\024\030 )Tj 0.598 Tw T* [(\024\021\007\036\035\036\027\017\016 )0.6(\022\024\035\024\023\030\024\022\021\024\035\024\020\017\017 )0.6(\217\025\207 )0.5(\204\003 )0.5(\217\230; )0.6(ORCID )]TJ 0 Tw 0 -1.218 TD (0000-0002-7479-4945)Tj /T1_2 1 Tf 0.023 Tw 0 -2.436 TD (INFORMATION ABOUT THE AUTHORS \(ORCID\))Tj /T1_1 1 Tf 0 Tw 0 -1.218 TD [(R)-10(ais R. S)-15.9(hak)-16(ir)-32(ov)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0001-8344-2696)Tj T* [(Y)35(ul)-31(i)-16(ia S. P)40.1(ankr)-33(a)15(t)17.1(ov)-15(a)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0001-7498-2412)Tj T* [(Anast)15(asiy)22.1(a M. Senina)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0002-9491-1694)Tj 0 -1.218 TD [(Eugenia A. Boul)35.1(ygina)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0003-3458-1176)Tj 0 -1.218 TD [(Ol)16(ga S. K)-15.9(ar)-33(asev)-15(a)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0002-8968-065X)Tj 0 -1.218 TD [(T)40(a)15(t)-32(iana V. G)20.1(r)-37(igor)-24(yev)-15(a)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0001-5314-7012)Tj T* [(Dina R. Y)50.1(ar)-22(ull)-31(ina)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0003-0717-302X)Tj T* [(Oleg Y. K)-15.9(ar)-24(pukhin)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0002-7479-4945)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 42.5896 481.2699 Tm [(\r\031\024\034\033)48(\026)45(\024)-10(\223\033)48(\026)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0 Tc 0.28 Tw 8 0 0 8 42.5197 468.4352 Tm (1.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (Chen)Tj /Span<>> BDC ( )Tj EMC (Y, Zhou)Tj /Span<>> BDC ( )Tj EMC [(J, W)12(ang)]TJ /Span<>> BDC ( )Tj EMC [(L. R)10.9(ole and mechanis)26(m of gut micr)-31.9(o)]TJ 0 Tw (-)Tj 0.048 Tw -1.296 -1.25 Td [(bio)17(t)15(a in human disease. )]TJ /T1_4 1 Tf [(F)27(ront Cell Infect Microbiol.)]TJ /T1_1 1 Tf ( 2021;11:625913. )Tj 0 Tw 0 -1.25 TD [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td [(10.3389/fc)-24(imb.2021.625913)]TJ 0 0 0 1 k /GS1 gs 0.142 Tw -1.847 -1.25 Td (2.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (Hasan)Tj /Span<>> BDC ( )Tj EMC [(N, Y)50(ang)]TJ /Span<>> BDC ( )Tj EMC [(H. F)20(a)-17(c)-16(t)17(or)-10(s af)-56(fec)-15.9(t)-32(ing t)-13(he com)10(posi)-24(t)-32(ion of t)-12.9(he gut )]TJ 0.018 Tw -1.296 -1.25 Td [(micr)-32(obio)17(t)15.1(a, and )0.5(i)-23.9(ts )0.5(modul)-16(a)15(t)-32(ion. )]TJ /T1_4 1 Tf 12.999 0 Td [(P)15(eer)]TJ /Span<>> BDC ( )Tj EMC 1.953 0 Td (J.)Tj /T1_1 1 Tf [( )0.5(2019;7:e7502. )0.5(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw 8.946 0 Td (10.7717/)Tj -23.899 -1.25 Td [(peer)-46(j.7502)]TJ 0 0 0 1 k /GS1 gs 0.029 Tw T* (3.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Y)50(ang)]TJ /Span<>> BDC ( )Tj EMC (M, Hong)Tj /Span<>> BDC ( )Tj EMC (G, Jin)Tj /Span<>> BDC ( )Tj EMC [(Y, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Mucosal-asso)-16(c)-23.9(ia)15(ted micr)-32(obio)17(t)15(a o)17(t)-13(her )]TJ 0.286 Tw -1.296 -1.25 Td [(t)-13(han l)35(uminal micr)-32(obio)17(t)15(a has a cl)30(ose r)-23.9(el)-16(a)15(t)-32(ionship wi)-24(t)-13(h diar)-24(r)-24(hea-)]TJ 0.195 Tw T* [(p)25(r)-24(ed)-16(ominant ir)-24(r)-37(i)-23.9(t)15(able bo)-14(wel syndr)-32(ome. )]TJ /T1_4 1 Tf [(F)27(ront Cell Infect Microbiol.)]TJ /T1_1 1 Tf 0 Tw ( )Tj 0.023 Tw T* [(2020;10:515614. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw [(10.3389/fc)-24(imb.2020.515614)]TJ 0 0 0 1 k /GS1 gs -0.09 Tw T* (4.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (\202\030\007\026\021\f\022\026\016)Tj /Span<>> BDC ( )Tj EMC (\204.\212., \202\004\022\026\f\024\r)Tj /Span<>> BDC ( )Tj EMC (\221.\222., \200\036\f\036\035\024\r)Tj /Span<>> BDC ( )Tj EMC (\200.\200., \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. \025\035\017\027\017\004\036\f\022\017\036 )Tj 0.012 Tc 0.458 Tw -1.296 -1.25 Td (\030\036\022\024\n\036\027\007\026\006\017\017. \212\017\r\036\030\021\017\ \022\031\035\016\030\027\026\016 \002\024\035\036\027\034. )Tj /T1_4 1 Tf -0.012 Tw [(\222\n\023\n\033\032\n\013\024\n\023\n\202\025\002.)12( )]TJ /T1_1 1 Tf 0 Tc 0.023 Tw T* [(2021;20\(3\):10\22627. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.33878/2073-7556-2021-20-3-10-27)Tj 0 0 0 1 k /GS1 gs 0.098 Tw T* (5.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(R)13(ei)-24(t)15(ano)]TJ /Span<>> BDC ( )Tj EMC [(E, F)10(r)-33(ancone)]TJ /Span<>> BDC ( )Tj EMC (E, Bona)Tj /Span<>> BDC ( )Tj EMC [(E, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Gut micr)-31.9(obio)17(t)15(a asso)-16(c)-24(ia)15(t)-32(ion )]TJ -0.013 Tw -1.296 -1.25 Td [(wi)-24(t)-13(h di)-16(ver)-21.9(t)-32(icul)-16(ar disease p)32(a)15(t)-13(ho)-16(genesis and p)25(r)-31.9(o)-16(gr)-24(ession: a sy)-13(stema)15.1(t)-32(ic )]TJ 0 Tw T* [(r)-24(ev)-15.9(iew. )]TJ /T1_4 1 Tf 0.023 Tw 3.194 0 Td (Dig Dis Sci.)Tj /T1_1 1 Tf [( 2022. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1007/s10620-022-07600-x)Tj 0 0 0 1 k /GS1 gs 0.086 Tw -3.194 -1.25 Td (6.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(S)-24(chief)-56(fer)]TJ /Span<>> BDC ( )Tj EMC [(KM, Sabe)-11(y)]TJ /Span<>> BDC ( )Tj EMC [(K, W)14(r)-36.9(ight)]TJ /Span<>> BDC ( )Tj EMC [(JR, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. T)47(he micr)-32(obial ecosy)-13(stem )]TJ 0.015 Tw -1.296 -1.25 Td [(dist)-32(inguishes )0.6(chr)-32(onicall)35(y )0.5(diseased )0.5(t)-32(issue )0.5(fr)-31.9(om ad)17(ja)-16.9(cent )0.5(t)-32(issue )0.5(in )0.5(t)-13(he )]TJ 0.108 Tw T* [(sigmoid col)30(on of chr)-31.9(onic, r)-24(ecur)-24(r)-23.9(ent di)-16(ver)-22(t)-32(icul)-30.9(i)-24(t)-32(is p)32(a)15(t)-32(ients. )]TJ /T1_4 1 Tf [(Sci R)21(ep.)]TJ /T1_1 1 Tf 0 Tw ( )Tj 0.023 Tw T* [(2017;7\(1\):8467. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1038/s41598-017-06787-8)Tj 0 0 0 1 k /GS1 gs 0.007 Tc 0.35 Tw T* (7.)Tj /Span<>> BDC ( )Tj EMC 1.317 0 Td [(P)-24(icc)-24(ioni)]TJ /Span<>> BDC ( )Tj EMC 3.934 0 Td [(A, )0.6(F)10(r)-33(anza)]TJ /Span<>> BDC ( )Tj EMC 4.602 0 Td [(L, )0.6(Br)-36.9(igid)42(a)]TJ /Span<>> BDC ( )Tj EMC 4.748 0 Td [(M, )0.6(e)-12(t)]TJ /Span<>> BDC ( )Tj EMC 2.89 0 Td [(al. )0.5(Gut )0.5(micr)-32(obio)17(t)15(a )0.6(and)7( )]TJ 0.005 Tc 0.349 Tw -17.491 -1.25 Td [(a)-16.7(cute di)-15.6(ver)-21.7(t)-31.7(icul)-30.6(i)-23.7(t)-31.6(is: r)-31.6(ole of p)25.3(r)-31.6(obio)17.3(t)-31.7(ics in mana)-16.7(gement of t)-12.7(his)5( )]TJ 0 Tc 0.228 Tw T* [(del)-31(ica)15(te p)32(a)15(t)-13(hophy)-13(siol)30(o)-16(gical bal)-15.9(ance. )]TJ /T1_4 1 Tf [(J P)15(ers Med.)]TJ /T1_1 1 Tf ( 2021;11\(4\):298. )Tj 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.3390/jpm11040298)Tj 0 0 0 1 k /GS1 gs 0.044 Tw -1.847 -1.25 Td (8.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(M)-24(oniuszko)]TJ /Span<>> BDC ( )Tj EMC [(A, R)-20(yd)17(zewsk)-17(a)]TJ /Span<>> BDC ( )Tj EMC [(G. T)47(he ef)-56(fec)-15.9(t of cycl)-31(ic r)-37(if)16(aximin t)-13(her)-33(apy )]TJ 0.002 Tw -1.296 -1.25 Td [(on )0.5(sym)10(pt)17(oms )0.5(of )0.5(di)-16(ver)-22(t)-32(icul)-15.9(ar )0.5(disease )0.5(fr)-32(om )0.5(t)-13(he )0.5(per)-10(spec)-16(t)-31.9(i)-16(ve )0.5(of )0.5(t)-13(he )0.5(gas)]TJ 0 Tw (-)Tj -0.02 Tw T* [(tr)-32(oenter)-31.9(ol)30(o)-16(g)16(y )0.5(outp)32(a)15(t)-32(ient )0.6(cl)-31(inic: )0.6(a )0.5(\231r)-24(eal-l)-30.9(ife\232 )0.5(stud)17.1(y. )]TJ /T1_4 1 Tf 20.621 0 Td [(Pr)-16(z )0.6(Gastroenterol. )]TJ /T1_1 1 Tf 0.023 Tw -20.621 -1.25 Td [(2017;12\(2\):145\22651. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.5114/pg.2017.68167)Tj 0 0 0 1 k /GS1 gs 0.118 Tw T* (9.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Y)50(ar)-22(ull)-30.9(ina)]TJ /Span<>> BDC ( )Tj EMC [(DR, S)-16(haf)-28(igull)-30.9(in)]TJ /Span<>> BDC ( )Tj EMC [(MU, Sakul)-30.9(in)]TJ /Span<>> BDC ( )Tj EMC [(KA, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Char)-32.9(a)-17(c)-16(ter)-37(iza)15(t)-32(ion )]TJ 0.094 Tw -1.296 -1.25 Td [(of gut )0.5(contr)-33(a)-17(c)-16(t)-32(il)-30.9(i)-24(t)-10(y and micr)-31.9(obio)17(t)15(a in p)32(a)15(t)-32(ients )0.5(wi)-24(t)-13(h sever)-23.9(e chr)-32(onic )]TJ 0 Tw T* [(const)-32(ip)32(a)15(t)-32(ion. )]TJ /T1_4 1 Tf 0.184 Tw 5.821 0 Td (PLoS ONE.)Tj /T1_1 1 Tf [( 2020;15\(7\):e0235985. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1371/jour)Tj 21.465 0 Td (-)Tj -27.286 -1.25 Td (nal.pone.0235985)Tj 0 0 0 1 k /GS1 gs 0.16 Tw T* (10.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(W)22(edel)]TJ /Span<>> BDC ( )Tj EMC [(T, Bar)-24(r)-23.9(enschee)]TJ /Span<>> BDC ( )Tj EMC [(M, L)-32(ange)]TJ /Span<>> BDC ( )Tj EMC [(C, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. M)-24(or)-23.9(phol)30(o)-16(gic basis for )]TJ -0.042 Tw -1.796 -1.25 Td [(devel)30(oping di)-16(ver)-22(t)-32(icul)-15.9(ar disease, di)-16(ver)-21.9(t)-32(icul)-31(i)-23.9(t)-32(is, and di)-16(ver)-22(t)-32(icul)-15.9(ar bleed)]TJ 0 Tw (-)Tj T* (ing. )Tj /T1_4 1 Tf 1.85 0 Td (Viszeralmedizin.)Tj /T1_1 1 Tf 0.023 Tw [( 2015;31\(2\):76\22682. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1159/000381431)Tj 0 0 0 1 k /GS1 gs 0.099 Tw -1.85 -1.25 Td (11.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(S)-16(he)-12(t)-13(h)]TJ /Span<>> BDC ( )Tj EMC [(A, Fl)30(o)-16(ch)]TJ /Span<>> BDC ( )Tj EMC [(M. P)35(r)-32(obio)17(t)-32(ics and di)-16(ver)-22(t)-32(icul)-15.9(ar disease. )]TJ /T1_4 1 Tf [(N)21(utr Clin )]TJ 0 Tw -1.796 -1.25 Td (Pract.)Tj /T1_1 1 Tf 0.023 Tw [( 2009;24\(1\):41\2264. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1177/0884533608329230)Tj 0 0 0 1 k /GS1 gs 0.049 Tw T* (12.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Sek)-16(ir)-31.9(ov)]TJ /Span<>> BDC ( )Tj EMC (I, Russell)Tj /Span<>> BDC ( )Tj EMC (SL, Antunes)Tj /Span<>> BDC ( )Tj EMC [(L)35(C, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Gut micr)-31.9(obio)17(t)15(a in heal)56(t)-13(h )]TJ 0.136 Tw -1.796 -1.25 Td (and disease. )Tj /T1_4 1 Tf [(Ph)12(ysiol R)21(ev.)]TJ /T1_1 1 Tf [( 2010;90\(3\):859\226904. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw [(10.1152/phy)-12.9(s)]TJ (-)Tj 29.055 47.5 Td [(r)-24(ev.00045.2009)]TJ 0 0 0 1 k /GS1 gs -0.034 Tw T* (13.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Di P)-24(ier)-24(r)-31.9(o)]TJ /Span<>> BDC ( )Tj EMC [(F. Gut micr)-31.9(obio)17(t)15(a p)32(ar)-33(ame)-12(ter)-10(s po)17(tent)-31.9(iall)35(y useful in cl)-31(ini)]TJ 0 Tw (-)Tj 0.307 Tw -1.796 -1.25 Td [(cal per)-10(spec)-15.9(t)-32(i)-16(ve. )]TJ /T1_4 1 Tf 0 Tw [(Microorg)12.1(anis)33(ms.)]TJ /T1_1 1 Tf 0.307 Tw [( 2021;9\(11\):2402. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.3390/)Tj T* [(micr)-32(o)-16(or)-31.9(ganis)26(ms9112402)]TJ 0 0 0 1 k /GS1 gs 0.132 Tw T* [(1)66(4.)]TJ /Span<>> BDC ( )Tj EMC 1.73 0 Td [(L)35(e)-11(y)]TJ /Span<>> BDC ( )Tj EMC 1.696 0 Td [(RE, )0.5(T)60(ur)-15(nbaugh)]TJ /Span<>> BDC ( )Tj EMC [(P)35.1(J, )0.5(Klein)]TJ /Span<>> BDC ( )Tj EMC 10.075 0 Td [(S, )0.5(e)-12(t)]TJ /Span<>> BDC ( )Tj EMC 2.208 0 Td [(al. )0.5(Micr)-32(obial )0.6(ecol)30(o)-16(g)16(y)28(: )0.5(human )]TJ -0.013 Tw -15.709 -1.25 Td (gut)Tj /Span<>> BDC ( )Tj EMC [(micr)-32(obes asso)-16(c)-23.9(ia)15(ted wi)-24(t)-12.9(h obesi)-24(t)-10(y)]TJ /T1_4 1 Tf [(. N)18(ature.)]TJ /T1_1 1 Tf [( 2)19.9(0)-16(06;4)13(4)13(4\(7)136(1)72(2)25(2\):1)45(0)25(2)25(2\226)]TJ 0.023 Tw T* [(3)31(. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs -0.045 Tc 0.045 Tw [(10)-30(.10)-21(3)-30.1(8)-45(/)-5(4)-32(4)-32(4)62(10)-20(2)-20(2)-45(a)]TJ 0 0 0 1 k /GS1 gs 0 Tc 0.044 Tw T* (15.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(P)40(ascale)]TJ /Span<>> BDC ( )Tj EMC [(A, Mar)-31.9(chesi)]TJ /Span<>> BDC ( )Tj EMC [(N, Mar)-24(ell)-30.9(i)]TJ /Span<>> BDC ( )Tj EMC [(C, e)-11.9(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Micr)-32(obio)17(t)15(a and me)-12(t)15(abol)-31(ic )]TJ 0.004 Tc -0.004 Tw -1.796 -1.25 Td (diseases. )Tj /T1_4 1 Tf 4.257 0 Td [(Endocr)-36.6(ine.)]TJ /T1_1 1 Tf 0.349 Tw [( 2018;61\(3\):357\226371. d)-15.5(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs -0.004 Tw [(10.1007/s)0.5(12020-)]TJ 0 Tc 0 Tw -4.257 -1.25 Td (018-1605-5)Tj 0 0 0 1 k /GS1 gs 0.241 Tw T* (16.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Duan)Tj /Span<>> BDC ( )Tj EMC (R, Zhu)Tj /Span<>> BDC ( )Tj EMC [(S, W)12(ang)]TJ /Span<>> BDC ( )Tj EMC [(B, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Al)56.1(ter)-33(a)15(t)-32(ions of gut micr)-32(obio)17.1(t)15(a )]TJ 0.21 Tw -1.796 -1.25 Td [(in p)32(a)15(t)-32(ients wi)-23.9(t)-13(h ir)-24(r)-36.9(i)-24(t)15(able bo)-14(wel syndr)-31.9(ome based on 16s r)-24(r)-15(na-t)15(ar)]TJ 0 Tw 27.286 0 Td (-)Tj 0.244 Tw -27.286 -1.25 Td [(ge)-12(ted sequenc)-24(ing: A sy)-13(stema)15(t)-32(ic r)-24(ev)-16(iew. )]TJ /T1_4 1 Tf [(Clin T)56(ransl Gastroenterol)]TJ /T1_1 1 Tf 0 Tw (. )Tj 0.023 Tw T* [(2019;10\(2\):e00012. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw [(10.14309/c)-16(tg.0000000000000012)]TJ 0 0 0 1 k /GS1 gs 0.116 Tw T* (17.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(L)-32(inninge)]TJ /Span<>> BDC ( )Tj EMC [(C, R)11(o)17(t)-13(h)]TJ /Span<>> BDC ( )Tj EMC [(B, Er)-30(l)-16(anson-Alber)-21.9(tsson)]TJ /Span<>> BDC ( )Tj EMC [(C, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. A)-14(bund)42(ance of )]TJ /T1_4 1 Tf 0 Tw -1.796 -1.25 Td [(Enterobacter)-36.9(iaceae )]TJ /T1_1 1 Tf -0.008 Tw 7.757 0 Td [(in t)-12.9(he col)30(on mucosa in di)-16(ver)-21.9(t)-32(icul)-16(ar disease. )]TJ /T1_4 1 Tf 0 Tw [(W)29(orld )]TJ 0.245 Tw -7.757 -1.25 Td [(J Gastrointest )0.5(P)18(athoph)12(ysiol.)]TJ /T1_1 1 Tf [( 2018;9\(1\):18\22627. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.4291/wjgp.)Tj T* (v9.i1.18)Tj 0 0 0 1 k /GS1 gs -0.013 Tw T* (18.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Ang)Tj /Span<>> BDC ( )Tj EMC [(MY, Dymo)-16(ck)]TJ /Span<>> BDC ( )Tj EMC [(D, T)40(an)]TJ /Span<>> BDC ( )Tj EMC [(JL, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC (al. Genome sequence of )Tj /T1_4 1 Tf 0 Tw [(P)18(ar)-42(vimonas )]TJ -1.796 -1.25 Td (micra)Tj /T1_1 1 Tf -0.004 Tw [( str)-32.9(ain A293, isol)-16(a)15(ted fr)-31.9(om an abd)-16(ominal abscess fr)-32(om a p)32(a)15(t)-32(ient )]TJ 0.257 Tw T* [(in t)-12.9(he U)13(ni)-24(ted Kingd)-16(om. )]TJ /T1_4 1 Tf (Genome Announc.)Tj /T1_1 1 Tf ( 2013;1\(6\):e01025\22613. )Tj 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1128/genomeA.01025-13)Tj 0 0 0 1 k /GS1 gs 0.003 Tc 0.35 Tw -1.847 -1.25 Td (19.)Tj /Span<>> BDC ( )Tj EMC 1.808 0 Td [(W)12(ang)]TJ /Span<>> BDC ( )Tj EMC 2.772 0 Td [(Q, )0.5(Huang )0.5(S-Q, )0.5(L)-32(i )0.5(C-Q, )0.5(e)-12(t)]TJ /Span<>> BDC ( )Tj EMC 11.625 0 Td (al. )Tj /T1_4 1 Tf 1.613 0 Td [(Akk)17(er)-14(mansia )0.5(muciniphi)]TJ 0 Tc 0 Tw (-)Tj -17.817 -1.25 Td (la)Tj /T1_1 1 Tf 0.298 Tw [( ma)15(y de)-12(ter)-15.9(mine chondr)-32(oi)-24(t)-32(in sulf)16.1(a)15(te amel)-31(ior)-32.9(a)15(t)-32(ing or a)-17(ggr)-33(av)-15(a)15(t)]TJ 0 Tw (-)Tj 0.005 Tc 0.349 Tw T* [(ing osteoar)-21.7(t)-12.7(hr)-36.8(i)-23.7(t)-31.7(is. )]TJ /T1_4 1 Tf [(F)27.2(ront Microbiol.)]TJ /T1_1 1 Tf [( 2017;8:1955. d)-15.8(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs -0.005 Tw (10.3389/)Tj 0 Tc 0 Tw T* (fmicb.2017.01955)Tj 0 0 0 1 k /GS1 gs 0.177 Tw T* (20.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Chen)Tj /Span<>> BDC ( )Tj EMC (J, Chen)Tj /Span<>> BDC ( )Tj EMC (X, Ho)Tj /Span<>> BDC ( )Tj EMC [(CL. R)13(ecent devel)30(opment of p)25(r)-32(obio)17.1(t)-32(ic bif)-28(i)]TJ 0 Tw (-)Tj 0.231 Tw -1.796 -1.25 Td [(d)-16(oba)-17(c)-16(ter)-36.9(ia for tr)-24(ea)15(t)-32(ing human diseases. )]TJ /T1_4 1 Tf [(F)27(ront Bioeng Bio)13.1(technol.)]TJ /T1_1 1 Tf 0 Tw ( )Tj 0.023 Tw T* [(2021;9:770248. d)-15.9(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.3389/fbioe.2021.770248)Tj 0 0 0 1 k /GS1 gs 0.341 Tw T* (21.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Gueimonde)Tj /Span<>> BDC ( )Tj EMC (M, Ouwehand)Tj /Span<>> BDC ( )Tj EMC [(A, Huht)-32(inen)]TJ /Span<>> BDC ( )Tj EMC [(H, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Q)-16(ual)-30.9(i)-24(t)15(a)15(t)-32(i)-16(ve )]TJ 0.149 Tw -1.796 -1.25 Td [(and quant)-31.9(i)-24(t)15(a)15(t)-32(i)-16(ve anal)35(y)-13(ses of t)-13(he bif)-27.9(id)-16(oba)-17(c)-16(ter)-37(ial micr)-32(obio)17(t)15(a in t)-13(he )]TJ 0.016 Tw T* [(col)30(onic mucosa of p)32(a)15(t)-32(ients wi)-24(t)-12.9(h col)30(or)-23.9(ec)-16(t)15(al cancer, di)-15.9(ver)-22(t)-32(icul)-30.9(i)-24(t)-32(is, and )]TJ 0.021 Tw T* [(infl)-15.9(amma)15(t)17(or)-24(y bo)-14(wel disease. )]TJ /T1_4 1 Tf [(W)29(orld J Gastroenterol.)]TJ /T1_1 1 Tf ( 2007;13:3985\2269. )Tj 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.3748/wjg.v13.i29.3985)Tj 0 0 0 1 k /GS1 gs 0.182 Tw -1.847 -1.25 Td (22.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(K)20(v)-15(asnovsk)-31.9(y)]TJ /Span<>> BDC ( )Tj EMC 4.999 0 Td [(CL, )0.5(L)35(eong)]TJ /Span<>> BDC ( )Tj EMC 4.32 0 Td [(LEX, )0.6(Cho)-16(o)]TJ /Span<>> BDC ( )Tj EMC [(JM, )0.5(e)-12(t)]TJ /Span<>> BDC ( )Tj EMC 7.387 0 Td [(al. )0.5(Cl)-30.9(inical )0.5(and )0.5(sym)10(p)]TJ 0 Tw (-)Tj 0.197 Tw -18.502 -1.25 Td [(t)17(om scor)-23.9(es ar)-24(e signif)-28(icantl)35.1(y cor)-24(r)-24(el)-15.9(a)15(ted wi)-24(t)-13(h fecal micr)-32(obio)17(t)15(a fea)]TJ 0 Tw (-)Tj 0.006 Tc 0.349 Tw T* [(t)0.5(u)0.5(r)-23.5(e)0.5(s)0.5( i)0.5(n)0.5( p)32.5(a)15.5(t)-31.5(i)0.5(e)0.5(n)0.5(t)0.5(s)0.5( w)0.5(i)-23.5(t)-12.4(h s)0.5(y)0.5(m)10.5(pt)17.5(o)0.5(m)0.5(a)15.5(t)-31.5(i)0.5(c)0.5( u)0.5(n)0.5(c)0.5(o)0.5(m)10.5(p)0.5(l)-30.5(i)0.5(c)0.5(a)15.5(t)0.5(e)0.5(d)0.5( d)0.5(i)-15.5(v)0.5(e)0.5(r)-21.5(t)-31.5(i)0.5(c)0.5(u)0.5(l)-15.5(a)0.5(r)6( )]TJ 0 Tc 0.045 Tw T* [(disease: A pil)30(o)17(t stud)17(y. )]TJ /T1_4 1 Tf (Eur J Gastroenterol Hepatol.)Tj /T1_1 1 Tf ( 2018;30:107\22612. )Tj 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1097/MEG.0000000000000995)Tj /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\033\030\031\030\213\b)-20.9(\035\231\213\233\t \021\032)50(\b)42(\032\231\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj /T1_5 1 Tf 25 0 0 25 504.6022 56.0378 Tm (115)Tj ET endstream endobj 1321 0 obj <>/Border[0 0 0]/H/N/Rect[57.2978 455.731 150.153 446.435]/Subtype/Link/Type/Annot>> endobj 1322 0 obj <>/Border[0 0 0]/H/N/Rect[233.71 435.731 263.622 426.275]/Subtype/Link/Type/Annot>> endobj 1323 0 obj <>/Border[0 0 0]/H/N/Rect[42.5197 425.731 77.4953 416.435]/Subtype/Link/Type/Annot>> endobj 1324 0 obj <>/Border[0 0 0]/H/N/Rect[114.572 385.731 207.427 376.435]/Subtype/Link/Type/Annot>> endobj 1325 0 obj <>/Border[0 0 0]/H/N/Rect[120.94 355.731 247.747 346.435]/Subtype/Link/Type/Annot>> endobj 1326 0 obj <>/Border[0 0 0]/H/N/Rect[140.292 325.731 237.315 316.275]/Subtype/Link/Type/Annot>> endobj 1327 0 obj <>/Border[0 0 0]/H/N/Rect[112.492 285.731 209.963 276.435]/Subtype/Link/Type/Annot>> endobj 1328 0 obj <>/Border[0 0 0]/H/N/Rect[57.2978 245.731 131.225 236.435]/Subtype/Link/Type/Annot>> endobj 1329 0 obj <>/Border[0 0 0]/H/N/Rect[124.94 205.731 203.603 196.435]/Subtype/Link/Type/Annot>> endobj 1330 0 obj <>/Border[0 0 0]/H/N/Rect[218.198 175.731 263.622 166.275]/Subtype/Link/Type/Annot>> endobj 1331 0 obj <>/Border[0 0 0]/H/N/Rect[42.5197 165.731 101.087 156.435]/Subtype/Link/Type/Annot>> endobj 1332 0 obj <>/Border[0 0 0]/H/N/Rect[188.815 135.731 254.727 126.275]/Subtype/Link/Type/Annot>> endobj 1333 0 obj <>/Border[0 0 0]/H/N/Rect[137.638 115.731 231.549 106.275]/Subtype/Link/Type/Annot>> endobj 1334 0 obj <>/Border[0 0 0]/H/N/Rect[215.951 95.7312 263.622 86.2752]/Subtype/Link/Type/Annot>> endobj 1335 0 obj <>/Border[0 0 0]/H/N/Rect[274.961 475.731 325.696 466.435]/Subtype/Link/Type/Annot>> endobj 1336 0 obj <>/Border[0 0 0]/H/N/Rect[466.151 455.731 496.063 446.275]/Subtype/Link/Type/Annot>> endobj 1337 0 obj <>/Border[0 0 0]/H/N/Rect[274.961 445.731 354.008 436.435]/Subtype/Link/Type/Annot>> endobj 1338 0 obj <>/Border[0 0 0]/H/N/Rect[297.909 415.731 355.869 406.435]/Subtype/Link/Type/Annot>> endobj 1339 0 obj <>/Border[0 0 0]/H/N/Rect[439.82 395.731 496.063 386.275]/Subtype/Link/Type/Annot>> endobj 1340 0 obj <>/Border[0 0 0]/H/N/Rect[274.961 385.731 312.592 376.435]/Subtype/Link/Type/Annot>> endobj 1341 0 obj <>/Border[0 0 0]/H/N/Rect[356.669 345.731 467.388 336.435]/Subtype/Link/Type/Annot>> endobj 1342 0 obj <>/Border[0 0 0]/H/N/Rect[448.495 315.731 496.063 306.275]/Subtype/Link/Type/Annot>> endobj 1343 0 obj <>/Border[0 0 0]/H/N/Rect[274.961 305.731 301.48 296.435]/Subtype/Link/Type/Annot>> endobj 1344 0 obj <>/Border[0 0 0]/H/N/Rect[289.739 265.731 382.658 256.435]/Subtype/Link/Type/Annot>> endobj 1345 0 obj <>/Border[0 0 0]/H/N/Rect[465.885 235.731 496.063 226.275]/Subtype/Link/Type/Annot>> endobj 1346 0 obj <>/Border[0 0 0]/H/N/Rect[274.961 225.731 333.712 216.435]/Subtype/Link/Type/Annot>> endobj 1347 0 obj <>/Border[0 0 0]/H/N/Rect[343.013 195.731 434.148 186.435]/Subtype/Link/Type/Annot>> endobj 1348 0 obj <>/Border[0 0 0]/H/N/Rect[289.739 145.731 375.81 136.435]/Subtype/Link/Type/Annot>> endobj 1349 0 obj <>/Border[0 0 0]/H/N/Rect[289.739 95.7312 399.514 86.4352]/Subtype/Link/Type/Annot>> endobj 1378 0 obj <> endobj 1377 0 obj <> endobj 1376 0 obj <> endobj 1375 0 obj <> endobj 1374 0 obj <> endobj 1373 0 obj <> endobj 1372 0 obj <> endobj 1371 0 obj <> endobj 1370 0 obj <> endobj 1369 0 obj <> endobj 1368 0 obj <> endobj 1367 0 obj <> endobj 1366 0 obj <> endobj 1365 0 obj <> endobj 1364 0 obj <> endobj 1363 0 obj <> endobj 1362 0 obj <> endobj 1361 0 obj <> endobj 1360 0 obj <> endobj 1359 0 obj <> endobj 1358 0 obj <> endobj 1357 0 obj <> endobj 1356 0 obj <> endobj 1355 0 obj <> endobj 1354 0 obj <> endobj 1353 0 obj <> endobj 1352 0 obj <> endobj 1351 0 obj <> endobj 1350 0 obj <> endobj 1318 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 0 0 0 1 k /GS1 gs /T1_0 1 Tf -0.016 Tw 10 0 0 10 70.8661 724.8299 Tm (\023\030\017\f\031\021\f\021\r\024\r\026\035 \r)Tj /Span<>> BDC ( )Tj EMC (\2251 \017)Tj /Span<>> BDC ( )Tj EMC (\2254 \(9,1% \017)Tj /Span<>> BDC ( )Tj EMC (5,2%, \f\024\024\021\r\036\021\f\021\r\036\027)Tj 0 Tw (-)Tj -0.007 Tw 0 -1.218 TD (\027\024\). \200)Tj /Span<>> BDC ( )Tj EMC (\r\024\f\023\026\035\036\027\027\t\b \007\017\r\036\030\021\017\022\031\035\ \026\b \024\002\027\026\030\031\032\036\027\t \017)Tj /Span<>> BDC ( )Tj EMC (\007\030\031)Tj 0 Tw (-)Tj 0.414 Tw T* (\020\017\036 \002\031\021\017\030\026\021-\023\030\024\007\031\006\017\030\ \031\033\013\017\036 \002\026\022\021\036\030\017\017)Tj /Span<>> BDC ( )Tj EMC (\227 )Tj /T1_1 1 Tf 0 Tw (Blautia, )Tj T* [(Cop)46(rococcus)]TJ /T1_0 1 Tf ( \017)Tj /Span<>> BDC ( )Tj EMC /T1_1 1 Tf [(R)19(osebur)-36.9(ia)]TJ /T1_0 1 Tf ( \(\230\026\002\035.)Tj /Span<>> BDC ( )Tj EMC (4\).)Tj 0.844 Tw T* (\202\027\026\035\017\017\030\031\016 \f\024\024\021\027\024\001\036\027\ \017\036 )Tj /T1_1 1 Tf 0 Tw [(Prev)13(o)13(tella)]TJ /T1_0 1 Tf (-\022-)Tj /T1_1 1 Tf (Bacteroides)Tj /T1_0 1 Tf ( )Tj T* (\()Tj /T1_1 1 Tf (P/B)Tj /T1_0 1 Tf 0.255 Tw (\), \n\t \024\002\027\026\030\031\032\017\035\017, \004\021\024 \r\024\f\ \023\026\035\036\027\017\036 \007\017\r\036\030\021\017\022\031)Tj 0 Tw (-)Tj 0.217 Tw 0 -1.218 TD (\035\026 \f\024\023\030\016\032\036\027\024 \f\024 \f\007\r\017\020\024\n\ \r)Tj /Span<>> BDC ( )Tj EMC (\f\021\024\030\024\027\031 \023\030\036\024\002\035\026\007\026\027\017\016\ )Tj /T1_1 1 Tf 0 Tw 0 -1.218 TD (Bacteroides )Tj /T1_0 1 Tf 0.31 Tw 5.084 0 Td (\(\230\026\002\035.)Tj /Span<>> BDC ( )Tj EMC (4\). \200\024 \r\f\036\b \017\f\f\035\036\007\024\r\026\027\027\t\b \024\ \002)Tj 0 Tw (-)Tj 0.2 Tw -5.084 -1.218 Td (\030\026\006\026\b \030\024\007 )Tj /T1_1 1 Tf 0 Tw (Bacteroides )Tj /T1_0 1 Tf 0.2 Tw 10.143 0 Td (\f\024\007\036\030\032\026\035\f\016 \r)Tj /Span<>> BDC ( )Tj EMC (\027\026\004\017\021\036\035\034\027\t\b )Tj 0.054 Tw -10.143 -1.218 Td (\022\024\035\017\004\036\f\021\r\026\b \(8,0\22640,1%\), \026)Tj /Span<>> BDC ( )Tj EMC (\r \024\002\030\026\006\036 \2254 \002\t\035 \f\026\n\t\n )Tj 0.206 Tw T* [(\n\027\024\020\024\004\017\f\035\036\027\027\t\n )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC (\n\017\022\030\024\002\027\024\n \f\024\024\002\013\036\f\021\r\036 \(40\ ,1%\), )Tj -0.004 Tw T* (\004\021\024 \b\024\030\024\001\024 \f\024\020\035\026\f\031\036\021\f\016\ \f)Tj /Span<>> BDC ( )Tj EMC (\022\035\017\027\017\004\036\f\022\024\005 \022\026\030\021\017\027\024\005\ \r\024\f)Tj 0 Tw (-)Tj 0.461 Tw 0 -1.218 TD [(\023\026\035\017\021\036\035\034\027\t\b )0.6(\024\f\035\024\032\027\036\027\017\005 )0.6(\212\207. )0.5(\206\030\026\n\024\021\030\017\006\026\021\036\035\034\027\t\036 )]TJ 0.122 Tw 0 -1.218 TD (\023\026\035\024\004\022\024\r\017\007\027\t\036 \026\220\030\024\002\027\ \t\036 \002\026\022\021\036\030\017\017 )Tj /T1_1 1 Tf 0 Tw (Bacteroides)Tj /T1_0 1 Tf 0.122 Tw ( spp., )Tj 0.206 Tw 0 -1.218 TD (\026)Tj /Span<>> BDC ( )Tj EMC 0.901 0 Td [(\021\026\022\032\036 )0.5(\r\t\007\036\035\036\027\027\t\036, )0.6(\f\024\020\035\026\f\027\024 )0.5(\f\024\r\030\036\n\036\027\027\024\005 )0.6(\f\017\f\021\036)]TJ 0 Tw (-)Tj 0.16 Tw -0.901 -1.218 Td [(\n\026\021\017\022\036, )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC [(\007\026\027\027\024\020\024 )0.5(\030\024\007\026 \r)]TJ /Span<>> BDC ( )Tj EMC [(\024\021\007\036\035\034\027\t\036 )0.5(\021\026\022\f\024\027\024\n\017\004\036)]TJ 0 Tw (-)Tj 0.305 Tw T* (\f\022\017\036 \036\007\017\027\017\006\t )Tj /T1_1 1 Tf 0 Tw [(P)18(arabacteroides)]TJ /T1_0 1 Tf 0.305 Tw ( spp., )Tj /T1_1 1 Tf 0 Tw [(Prev)13(o)13(tella)]TJ /T1_0 1 Tf 0.305 Tw ( spp., )Tj /T1_1 1 Tf 0 Tw T* [(P)15(or)-18(ph)12(yromonas)]TJ /T1_0 1 Tf 0.229 Tw ( spp. \017)Tj /Span<>> BDC ( )Tj EMC (\027\036\022\024\021\024\030\t\036 \007\030\031\020\017\036, \004\026\f\021\ \024 \r\t)Tj 0 Tw (-)Tj 0.09 Tw T* (\016\r\035\016\033\021\f\016 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\023\024\035\017\n\017\022\030\024\002\027\t\b \017\027\235\036\022\006\017\ \016\b \f\035\017\017\f\021\t\b )Tj 0.263 Tw T* (\024\002\024\035\024\004\036\022, \r)Tj /Span<>> BDC ( )Tj EMC (\004\026\f\021\027\024\f\021\017, \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\021\016\032\036\035\t\b \017\027\021\030\026\026\002\007\024\n\017)Tj 0 Tw (-)Tj 0.036 Tw T* (\027\026\035\034\027\t\b \017\027\235\036\022\006\017\016\b. \207\026\022\ \021\036\030\024\017\007\027\t\036 \017\027\235\036\022\006\017\017 \r\f\ \021\030\036)Tj 0 Tw (-)Tj 0.038 Tw T* [(\004\026\033\021\f\016 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC [(\035\033\002\t\b \031\004\026\f\021\022\026\b )0.5(\021\036\035\026, \r\022\035\033\004\026\016 \006\036\027\021\030\026\035\ \034\027\031\033 )]TJ 0.011 Tw T* (\027\036\030\r\027\031\033 \f\017\f\021\036\n\031, \020\024\035\024\r\031\ \017)Tj /Span<>> BDC ( )Tj EMC (\001\036\033, \020\030\031\007\027\031\033 \022\035\036\021\022\031, \r\027\ \031)Tj 0 Tw (-)Tj 0.151 Tw T* (\021\030\036\027\027\017\036 \024\030\020\026\027\t, \022\024\032\031 \017\ )Tj /Span<>> BDC ( )Tj EMC (\n\016\020\022\017\036 \021\022\026\027\017, \027\024 \024\004\026\020 \r\ \024\f)Tj 0 Tw (-)Tj 0.123 Tw T* [(\023\026\035\036\027\017\016, )0.6(\022\026\022 )0.5(\023\030\026\r\017\035\024, )0.5(\030\026\f\023\024\035\026\020\026\036\021\f\016 )0.6(\r)]TJ /Span<>> BDC ( )Tj EMC 16.776 0 Td [(\240\025\230, )0.5(\021\024 )0.5(\036\f\021\034 )]TJ 0.54 Tw -16.776 -1.218 Td [(\031\004\026\f\021\022\036, )0.5(\022\024\035\024\027\017\017\030\024\r\026\027\027\024\n )0.6(\007\026\027\027\t\n\017 )0.6(\002\026\022\021\036\030\017\016\n\017 )]TJ 0 Tw T* ([24].)Tj 0.781 Tw T* (\025\030\024\n\036 \021\024\020\024, \f\024\007\036\030\032\026\027\017\036\ \r)Tj /Span<>> BDC ( )Tj EMC (\022\017\001\036\004\027\017\022\036 \030\024\007\024\r )Tj /T1_1 1 Tf 0 Tw T* [(Prev)13(o)13(tella)]TJ /T1_0 1 Tf 0.353 Tw ( \017)Tj /T1_1 1 Tf /Span<>> BDC ( )Tj EMC (Bacteroides)Tj /T1_0 1 Tf ( \024\023\030\036\007\036\035\016\036\021 \220\027\021\036\030\024\021\017\ \023 \004\036)Tj 0 Tw (-)Tj 0.216 Tw T* (\035\024\r\036\022\026. \224\027\021\036\030\024\021\017\023 1 \b\026\030\ \026\022\021\036\030\017\031\036\021\f\016 \024\021\027\024\f\017\021\036\ \035\034\027\024 )Tj 0.108 Tw T* [(\r\t\f\024\022\024\005 )0.5(\004\017\f\035\036\027\027\024\f\021\034\033 )]TJ /T1_1 1 Tf 0 Tw 10.008 0 Td (Bacteroides)Tj /T1_0 1 Tf 0.108 Tw [( )0.5(spp., )0.5(\026)]TJ /Span<>> BDC ( )Tj EMC 7.899 0 Td (\220\027\021\036\030\024\021\017\023 )Tj 0.095 Tw -17.907 -1.218 Td (2)Tj /Span<>> BDC ( )Tj EMC (\227 )Tj /T1_1 1 Tf 0 Tw [(Prev)13(o)13(tella)]TJ /T1_0 1 Tf 0.095 Tw ( spp. [25]. \224\027\021\036\030\024\021\017\023 1 \004\026\013\036 \r\f\ \021\030\036\004\026)Tj 0 Tw (-)Tj 0.251 Tw T* (\036\021\f\016 \031)Tj /Span<>> BDC ( )Tj EMC (\035\033\007\036\005, \023\030\017\007\036\030\032\017\r\026\033\013\017\ \b\f\016 \026\023\026\007\027\024\005 \007\017\036\021\t )Tj 0.192 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\r\t\f\024\022\017\n \023\024\021\030\036\002\035\036\027\017\036\n \032\ \017\r\024\021\027\024\020\024 \002\036\035\022\026 \017)Tj /Span<>> BDC ( )Tj EMC (\027\026\f\t)Tj 0 Tw (-)Tj 0.094 Tw T* [(\013\036\027\027\t\b )0.6(\032\017\030\024\r, )0.6(\026)]TJ /Span<>> BDC ( )Tj EMC 7.505 0 Td [(\220\027\021\036\030\024\021\017\023 )0.6(2)]TJ /Span<>> BDC ( )Tj EMC 5.356 0 Td [(\227 )0.5(\023\030\017)]TJ /Span<>> BDC ( )Tj EMC 3.174 0 Td [(\007\017\036\021\036, )0.6(\002\024\020\026\021\024\005 )]TJ 0.229 Tw -16.035 -1.218 Td (\031\020\035\036\r\024\007\026\n\017 \017)Tj /Span<>> BDC ( )Tj EMC (\022\035\036\021\004\026\021\022\024\005 [26]. \230\036\n \027\036 \n\036\ \027\036\036, \022\024\027)Tj 0 Tw (-)Tj 0.221 Tw T* (\006\036\027\021\030\026\006\017\016 \b\024\035\036\f\021\036\030\017\027\ \026 \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\026\021\036\030\024\020\036\027\027\024\020\024 \n\036\021\026\ \002\024)Tj 0 Tw (-)Tj 0.18 Tw T* [(\035\017\021\026 )0.5(\021\030\017\n\036\021\017\035\026\n\017\027-N-\024\022\f\017\007\026 )0.7(\(\230\204\202\210\) )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 16.979 0 Td [(\023\035\026\n\036 )0.5(\022\030\024)]TJ 0 Tw (-)Tj 0.236 Tw -16.979 -1.218 Td (\r\017 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\220\027\021\036\030\024\021\017\023\036 2 \002\t\035\026 \027\026\004\017\ \021\036\035\034\027\024 \r\t\001\036, \004\036\n )Tj 0 Tw T* (\023\030\017)Tj /Span<>> BDC ( )Tj EMC (\220\027\021\036\030\024\021\017\023\036 1 [27,28].)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 70.936 213.3538 Tm [(\020)21(\026\027\r\242\224\034\022\031\034)]TJ 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0 Tc 0.136 Tw 10 0 0 10 70.8661 188.9978 Tm (\200 \023\030\024\r\036\007\036\027\027\024\n \023\017\035\024\021\027\024\ \n \017\f\f\035\036\007\024\r\026\027\017\017 \023\030\036\007\023\030\017\ \027\016)Tj 0 Tw (-)Tj 0.081 Tw T* (\021\026 \023\024\023\t\021\022\026 \023\030\024\f\035\036\007\017\021\034\ \017\027\007\017\r\017\007\031\026\035\034\027\t\005 \f\024\f\021\026\r\ \023\030\017)Tj 0 Tw (-)Tj 0.334 Tw T* (\f\021\036\027\024\004\027\024\005 \n\017\022\030\024\002\017\024\021\t \ \007\017\r\036\030\021\017\022\031\035\024\r \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r )Tj 0.235 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\022\035\017\027\017\022\024\005 \024\f\021\030\t\b \017)Tj /Span<>> BDC ( )Tj EMC (\b\030\024\027\017\004\036\f\022\017\b \r\024\f\023\026\035\017\021\036\035\ \034\027\t\b )Tj 0.358 Tw T* (\024\f\035\024\032\027\036\027\017\005 \212\207. \202\027\026\035\017 \n\ \017\022\030\024\002\017\024\021\t \r\027\031\021\030\017 \r\024\f)Tj 0 Tw (-)Tj 0.238 Tw T* (\023\026\035\036\027\027\t\b \007\017\r\036\030\021\017\022\031\035\024\r\ \023\024\r\024\035\017\035 \r\t\016\r\017\021\034 \024\023\030\036\007\ \036)Tj 0 Tw (-)Tj 0.344 Tw T* (\035\036\027\027\t\036 \f\007\r\017\020\017 \r)Tj /Span<>> BDC ( )Tj EMC (\022\017\001\036\004\027\024\n \n\017\022\030\024\002\017\024\n\036, \022\ \024\021\024\030\t\036 )Tj 0.39 Tw T* (\n\024\020\031\021 \f\023\024\f\024\002\f\021\r\024\r\026\021\034 \023\030\ \024\020\030\036\f\f\017\030\024\r\026\027\017\033 \r\024\f\023\026\035\036\ )Tj 0 Tw (-)Tj 0.296 Tw T* (\027\017\016 \r)Tj /Span<>> BDC ( )Tj EMC (\007\017\r\036\030\021\017\022\031\035\036 \r\023\035\024\021\034 \007\024\ )Tj /Span<>> BDC ( )Tj EMC (\036\020\024 \r\024\f\023\026\035\017\021\036\035\034\027\024\005 )Tj 0.502 Tw T* (\007\036\f\021\030\031\022\006\017\017. \203\026)Tj /Span<>> BDC ( )Tj EMC (\235\024\027\036 \r\t\016\r\035\036\027\027\t\b \f\031\013\036\f\021\r\036\ \027\027\t\b )Tj 0.18 Tw 23.244 64.543 Td (\030\026\035\017\004\017\005 \n\036\032\007\031 \n\017\022\030\024\002\027\ \t\n\017 \f\024\024\002\013\036\f\021\r\026\n\017 \r\024\f\023\026)Tj 0 Tw (-)Tj 0.081 Tw T* (\035\036\027\027\t\b \007\017\r\036\030\021\017\022\031\035\024\r, \r\024\ \r\f\036\b \r)Tj /Span<>> BDC ( )Tj EMC (\027\026\004\017\021\036\035\034\027\024\n \022\024\035\017)Tj 0 Tw (-)Tj 0.091 Tw T* (\004\036\f\021\r\036 \f\024\007\036\030\032\026\035\017\f\034 \220\027\021\ \036\030\024\002\026\022\021\036\030\017\017, \026)Tj /Span<>> BDC ( )Tj EMC (\f\024\024\021\027\024\001\036\027\017\036 )Tj /T1_1 1 Tf 0 Tw T* [(Prev)13(o)13(tella)]TJ /T1_0 1 Tf (-\022-)Tj /T1_1 1 Tf (Bacteroides)Tj /T1_0 1 Tf -0.076 Tw ( \(P/B\) \002\t\035\024 \f\n\036\013\036\027\024 \r)Tj /Span<>> BDC ( )Tj EMC (\f\021\024\030\024\027\031 )Tj 0 Tw T* (\023\030\036\024\002\035\026\007\026\027\017\016 )Tj /T1_1 1 Tf 6.109 0 Td (Bacteroides)Tj /T1_0 1 Tf 0.004 Tw [(. )0.5(\200)]TJ /Span<>> BDC ( )Tj EMC 5.856 0 Td [(\021\030\036\b )0.5(\024\002\030\026\006\026\b )]TJ /T1_1 1 Tf 0 Tw 6.079 0 Td [(Fir)-14(micutes)]TJ /T1_0 1 Tf ( )Tj 0.142 Tw -18.044 -1.218 Td (\023\030\036\024\002\035\026\007\026\035\017 \027\026\007 )Tj /T1_1 1 Tf 0 Tw (Bacteroidetes )Tj /T1_0 1 Tf 0.142 Tw 13.279 0 Td (\(\r \024\002\030\026\006\026\b \2251, \2252, )Tj 0 Tw -13.279 -1.218 Td (\2253\))Tj /T1_1 1 Tf ( )Tj /T1_0 1 Tf 0.242 Tw 2.184 0 Td (\017)Tj /Span<>> BDC ( )Tj EMC (\024\021\n\036\004\036\027\024 \007\024\n\017\027\017\030\024\r\026\027\017\ \036 \024\021\007\036\035\034\027\t\b \030\024\007\024\r: )Tj /T1_1 1 Tf 0 Tw -2.184 -1.218 Td [(P)18(ar)-42(vimonas)]TJ /T1_0 1 Tf 0.079 Tw ( \(21,0% \r)Tj /Span<>> BDC ( )Tj EMC (\2252\), )Tj /T1_1 1 Tf 0 Tw [(Akk)17(er)-14(mansia)]TJ /T1_0 1 Tf 0.079 Tw ( \(30,6% \r)Tj /Span<>> BDC ( )Tj EMC (\2253\), )Tj /T1_1 1 Tf 0 Tw T* (Bacteroides)Tj /T1_0 1 Tf 0.11 Tw ( \017)Tj /Span<>> BDC ( )Tj EMC /T1_1 1 Tf 0 Tw [(Bi\233dobacter)-36.9(ium)]TJ /T1_0 1 Tf 0.11 Tw ( \(\f\024\024\021\r\036\021\f\021\r\036\027\027\024, 40,1% )Tj 0.096 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (10,3% \r)Tj /Span<>> BDC ( )Tj EMC (\2254\). \025)Tj /Span<>> BDC ( )Tj EMC (\035\017\n\017\021\017\030\031\033\013\017\n\017 \235\026\022\021\024\030\ \026\n \r\t\023\024\035)Tj 0 Tw (-)Tj 0.016 Tw T* (\027\036\027\027\024\020\024 \017\f\f\035\036\007\024\r\026\027\017\016 \ \024\021\027\024\f\016\021\f\016 \024\020\030\026\027\017\004\036\027\027\ \024\f\021\034 \017\f)Tj 0 Tw (-)Tj 0.026 Tw T* (\f\035\036\007\024\r\026\027\027\024\020\024 \031\004\026\f\021\022\026 \ \022\017\001\036\004\027\017\022\026 \017)Tj /Span<>> BDC ( )Tj EMC (\027\036\002\024\035\034\001\024\036 \004\017\f\035\024 )Tj -0.005 Tw T* (\023\026\006\017\036\027\021\024\r. \212\035\016 \r\t\016\r\035\036\027\017\ \016 \007\024\f\021\024\r\036\030\027\024\005 \017\027\235\024\030\n\026\ \006\017\017 )Tj -0.001 Tw T* (\024)Tj /Span<>> BDC ( )Tj EMC 0.732 0 Td [(\026\022\024\027\024\n\036\030\027\024\f\021\016\b )0.6(\007\017\027\026\n\017\022\017 )0.5(\n\017\022\030\024\002\017\024\021\t )0.6(\r)]TJ /Span<>> BDC ( )Tj EMC 17.673 0 Td (\007\017\r\036\030\021\017)Tj 0 Tw (-)Tj 0.122 Tw -18.404 -1.218 Td (\022\031\035\036 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\r\024\f\023\026\035\017\021\036\035\034\027\t\b \024\f\035\024\032\027\036\ \027\017\016\b \027\036\024\002\b\024\007\017\n\t )Tj 0.416 Tw T* [(\017\f\f\035\036\007\024\r\026\027\017\016 )0.6(\002\024\035\034\001\017\b )0.5(\030\026\027\007\024\n\017\017\030\024\r\026\027\027\t\b )0.6(\020\030\031\023\023 )]TJ 0.062 Tw T* (\023\026\006\017\036\027\021\024\r. \230\036\n \027\036 \n\036\027\036\036\ , \023\024\035\031\004\036\027\027\t\036 \007\026\027\027\t\036 \024)Tj /Span<>> BDC ( )Tj EMC (\f\023\036)Tj 0 Tw (-)Tj 0.259 Tw T* (\006\017\235\017\022\036 \023\030\017\f\021\036\027\024\004\027\024\005 \ \n\017\022\030\024\002\017\024\021\t \r)Tj /Span<>> BDC ( )Tj EMC (\007\017\r\036\030\021\017\022\031\035\026\b )Tj 0.405 Tw T* (\030\036\036\006\017\030\024\r\026\027\027\t\b \023\030\036\023\026\030\ \026\021\024\r \022\017\001\022\017 \023\030\036\007\f\021\026\r\035\016\ \033\021, )Tj 0.044 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC (\027\026\001 \r\020\035\016\007, \022\035\017\027\017\004\036\f\022\017\ \005 \017\027\021\036\030\036\f \017)Tj /Span<>> BDC ( )Tj EMC (\n\024\020\031\021 \f\023\024\f\024\002)Tj 0 Tw (-)Tj 0.152 Tw T* (\f\021\r\024\r\026\021\034 \023\024\f\021\030\024\036\027\017\033 \023\035\ \026\027\026 \007\026\035\034\027\036\005\001\017\b \017\f\f\035\036\007\ \024\r\026)Tj 0 Tw (-)Tj 0.001 Tw T* [(\027\017\005, )0.5(\027\026\023\030\026\r\035\036\027\027\t\b )0.5(\027\026)]TJ /Span<>> BDC ( )Tj EMC 9.344 0 Td [(\023\024\027\017\n\026\027\017\036 )0.6(\023\026\021\024\020\036\027\036\026 )0.5(\026\002\024\035\036)]TJ 0 Tw (-)Tj 0.09 Tw -9.344 -1.218 Td (\r\026\027\017\016, \023\024\017\f\022 \027\024\r\t\b \n\036\021\024\007\ \024\r \220\235\235\036\022\021\017\r\027\024\020\024 \035\036\004\036\027\ \017\016, )Tj 0.083 Tw T* [(\022\031\023\017\030\024\r\026\027\017\016 \r\024\f\023\026\035\036\027\017\ \016 )0.5(\007\017\r\036\030\021\017\022\031\035\024\r \017)]TJ /Span<>> BDC ( )Tj EMC (\023\030\024\235\017\035\026\022)Tj 0 Tw (-)Tj T* (\021\017\022\017 \030\036\006\017\007\017\r\024\r.)Tj /T1_3 1 Tf 0.023 Tw 0 -2.436 TD (\223\030\032\255\020\034\036 \032\026\020\017\022\017\026)Tj /T1_0 1 Tf 0.188 Tw 0 -1.218 TD [(\025)-4.1(\024)-4.3(\027)1.7(\006)-6(\036)-6.8(\023)2.2(\006)-6(\017)-5.4(\016 \017)]TJ /Span<>> BDC ( )Tj EMC [(\007)-6(\017)2.7()-9.9(\026\005)1.7(\027 \017)-2.4(\f)3.1(\f)-38.9(\035)-6.8(\036)-19(\007)-4.4(\024)-4.3(\r)-8.9(\026\027)1.8(\017)-5.5(\016)13.7(:)]TJ /T1_1 1 Tf -0.027 Tc 0.215 Tw [( \222)-10.9(\026)-25.1(\032)-21.1(\033)-18.2(\205)-41.4(\004)-19.6(\025)-19.8(\021)]TJ /Span<>> BDC 19.675 0 Td ( )Tj EMC [(\255)0.6(.)0.5(\223.)-19.2(,)-27( )]TJ -0.01 Tc 0.01 Tw -19.675 -1.218 Td [(\243)5.8(\032\205)13.8(\023)-3.6(\023\025)-2.8(\021\026)]TJ /Span<>> BDC 3.811 0 Td ( )Tj EMC [(\200)-8.6(.)19.3(\212)83.9(.)]TJ /T1_0 1 Tf 0 Tc 0.735 Tw -3.811 -1.218 Td [(\221)-4.6(\002)-9.9(\024)0.7(\030 \017)]TJ /Span<>> BDC ( )Tj EMC [(\024)-11.8(\002)3(\030)-11.4(\026)-6.3(\002)-9.9(\024)-10.9(\021)-17.7(\022)-19.1(\026 \n)1.3(\026)-11.8(\021)-9.9(\036)-1.7(\030)-7.6(\017)-0.6(\026)-33.1(\035)-2.5(\024)-4.3(\r)10.4(:)]TJ /T1_1 1 Tf [( \231)14.1(\026)4.8(\013)12.7(\025)4.7(\032\n)9.6(\027)]TJ /Span<>> BDC ( )Tj EMC [(\212)93.9(.)29.3(\212)93.9(.)7.9(, )]TJ 0.752 Tw T* [()15.1(\026)4.3(\021)10.7(\013)2(\032)3(\026)1.9(\024)4(\n)9.6(\027)2.1(\026)]TJ /Span<>> BDC ( )Tj EMC [(\223)26.6(.)43.7(\207)-2(.)7.8(, \222)16.1(\026)1.8(\032)3(\026\t)9.8(\031)6.6(\027)2.2(\026)]TJ /Span<>> BDC ( )Tj EMC [(\255)27.6(.)43.7(\207)-2.1(.)7.8(, \207)8.7(\031)2.4(\021)10.1(\025)7.2(\021)9.5(\026)]TJ /Span<>> BDC ( )Tj EMC [(\201)-2.3(.)20.1(\240)19.4(.)7.8(, )]TJ -0.007 Tc 0.007 Tw T* [(\213)12.2(\205)16.8(\023\020)8.1(\202)3(\025\021)2.5(\026)]TJ /Span<>> BDC 3.85 0 Td ( )Tj EMC [(\036)15.8(.\201)-9.3(.)]TJ /T1_0 1 Tf 0.018 Tc -0.052 Tw -3.85 -1.218 Td [(\221)35.2(\021)-3.5(\026)6.2(\021\017)15.7(\f)-18(\021\017)22.5(\004)9.8(\036)7.6(\f)16.4(\022)-1.1(\026)-3(\016)18( \024)6.2(\002)21(\030)6.6(\026)11.8(\002)8.1(\024)7.1(\021\022)-1.1(\026)21.7(:)]TJ /T1_1 1 Tf 0 Tc -0.034 Tw 11.315 0 Td [( \222)16.1(\026)1.8(\032)3(\026\t)9.8(\031)6.6(\027)2.1(\026)]TJ /Span<>> BDC ( )Tj EMC [(\255)27.6(.)43.7(\207)-2.1(.)7.8(, \207)8.8(\031)2.3(\021)10.1(\025)7.2(\021)9.5(\026)]TJ /Span<>> BDC ( )Tj EMC [(\201)-2.3(.)20.1(\240)19.4(.)]TJ /T1_0 1 Tf -0.01 Tc 0.01 Tw -11.315 -1.218 Td [(\202)-15.1(\r)-22.3(\021)-16.5(\024)-9.3(\030)-9.9( \030)-17.6(\017)-12.4(\f)-44.5(\031)-21.3(\027)-8.3(\022)-10.7(\024)-14.3(\r:)]TJ /T1_1 1 Tf -0.009 Tc 0.009 Tw 6.859 0 Td [( \207\031)-6.7(\021)1.1(\025)-1.8(\021)0.5(\026)]TJ /Span<>> BDC 3.057 0 Td ( )Tj EMC [(\201)-11.3(.)11.1(\240)10.4(.)]TJ /T1_0 1 Tf 0.002 Tc -0.002 Tw -9.916 -1.218 Td [(\203)7.2(\026\023)4.2(\017\f)-10.8(\026)1.7(\027)3.7(\017)-6.7(\036)2.1( \021)-7.9(\036)-3.4(\022\f)-34(\021)-19.5(\026)5.7(:)]TJ /T1_1 1 Tf -0.007 Tc 0.007 Tw 7.694 0 Td [( \222)9.1(\026)-5.2(\032)-1.1(\033)1.8(\205)-21.4(\004\025\021)]TJ /Span<>> BDC 4.054 0 Td ( )Tj EMC [(\255)20.6(.)20.5(\223)19.6(.)0.8(,)-7( \243)8.8(\032)3.2(\205)16.9(\023)-0.6(\023)2.6(\025\021)2.5(\026)]TJ /Span<>> BDC 6.292 0 Td ( )Tj EMC [(\200)-5.6(.)22.3(\212)86.9(.)]TJ /T1_0 1 Tf 0 Tc 0 Tw -18.04 -1.218 Td [(\217)5.5(\036)-19(\007)-20.1(\026\022)-32.6(\021)-17.7(\017)1.4(\030)-11.8(\024)-4.2(\r)-9(\026\027)1.8(\017)-8.7(\036)6.5(:)]TJ /T1_1 1 Tf 0.657 Tw [( )0.5(\222)16.1(\026)1.8(\032)5.9(\033)8.8(\205)-14.4(\004)7.4(\025)7.2(\021)]TJ /Span<>> BDC ( )Tj EMC 12.735 0 Td [(\255)27.6(.)27.5(\223)26.6(.)7.8(, )0.5(\243)15.8(\032)10.2(\205)23.8(\023)6.4(\023)9.6(\025)7.2(\021)9.6(\026)]TJ /Span<>> BDC ( )Tj EMC 7.605 0 Td [(\200)1.4(.)29.3(\212)93.9(.)7.8(, )]TJ -0.007 Tc 0.007 Tw -20.34 -1.218 Td [(\210)94.1(\032)-0.6(\025)8.1(\202)-3.3(\n)-2.1(\032)0.5(\022)-6.4(\031\027)-4.9(\026)]TJ /Span<>> BDC 4.463 0 Td ( )Tj EMC [(\220)58(.)21.5(\216)17.3(.)]TJ /T1_3 1 Tf 0 Tc 0.023 Tw -4.463 -2.436 Td (AUTHORS CONTRIBUTION)Tj /T1_0 1 Tf 0.188 Tw T* [(C)-6.5(o)0.8(nce)-0.7(p)-12.3(t a)2.4(n)-4.5(d d)-5.5(e)-13.3(s)-16.6(i)3.2(g)1.2(n o)-2.2(f )0.5(t)-16.7(h)-5.3(e s)-20(t)-12.7(ud)-10.9(y)-11.8(:)]TJ /T1_1 1 Tf [( O)-7.4(l)4.8(e)-3.5(g)]TJ /Span<>> BDC ( )Tj EMC 16.828 0 Td [(Y)57.6(.)]TJ /Span<>> BDC ( )Tj EMC [(K)12.9(ar)-20.4(p)1.4(u)4.6(k)5.3(h)6.2(i)8.4(n)-6(, )]TJ 0 Tw -16.828 -1.218 Td [(D)-8(i)8.4(n)4.8(a)]TJ /Span<>> BDC ( )Tj EMC [(R)-2.5(.)]TJ /Span<>> BDC ( )Tj EMC [(Y)39.3(ar)-5(u)2.8(ll)4.3(i)8.4(n)4.9(a)]TJ /T1_0 1 Tf 1.014 Tw T* [(C)-6.5(o)-5.8(l)-19(l)-14.3(e)-9.4(c)-32.5(t)-37.4(i)3.2(o)0.9(n )0.5(a)2.4(n)-4.6(d )0.6(p)-3.8(r)-6(o)-7(ce)-13.3(s)-12.8(s)-16.6(i)7.1(n)-1.9(g )0.6(o)-2.2(f )0.5(t)-16.6(h)-5.3(e )0.5(m)1.8(a)-8.4(t)-15.1(e)-2.2(r)-47.9(i)5.1(a)-1.5(l)-22.5(:)]TJ /T1_1 1 Tf 0 Tw ( )Tj -0.154 Tw T* [(R)10.1(a)-2(i)11(s)]TJ /Span<>> BDC ( )Tj EMC [(R)-2.5(.)]TJ /Span<>> BDC ( )Tj EMC [(S)15.3(h)4.8(a)1.7(k)-18.5(i)9.4(r)2.4(ov)33.6(, Y)33.7(u)2.8(l)4.4(i)3.4(i)5.9(a)]TJ /Span<>> BDC ( )Tj EMC [(S)2.1(.)]TJ /Span<>> BDC ( )Tj EMC [(P)30.8(a)-0.8(n)7.5(k)2.9(r)7.7(a)-4.9(t)1.4(o)-0.6(v)10.8(a)-14(, A)3.8(n)4.8(a)-3(s)-10.7(t)2.4(a)-3(s)-8.3(iy)3.8(a)]TJ /Span<>> BDC ( )Tj EMC [(M)5.4(.)]TJ /Span<>> BDC ( )Tj EMC [(S)5.6(e)-2.6(n)6.2(i)8.4(n)4.8(a)-14(, )]TJ 0 Tw T* [(E)25.4(u)2.1(g)-2.5(e)-2.6(n)6.2(i)5.9(a)]TJ /Span<>> BDC ( )Tj EMC [(A)-12.5(.)]TJ /Span<>> BDC ( )Tj EMC [(B)0.8(o)0.9(u)2.8(l)11(y)3(g)-14.5(i)8.4(n)4.8(a)-13.9(, O)-7.4(l)4.7(ga)]TJ /Span<>> BDC ( )Tj EMC [(S)2.1(.)]TJ /Span<>> BDC ( )Tj EMC [(K)12.9(ar)7.7(a)-3(s)4.9(e)-4(v)10.8(a)]TJ /T1_0 1 Tf -0.007 Tc 1.079 Tw T* [(St)-34.7(a)-15.4(t)-44.4(i)-4.3(s)-27(t)-44.4(i)-1.8(c)-18.8(a)-8.5(l)-7( p)-10.8(r)-13(o)-14(c)-6.8(e)-20.2(s)-19.8(s)-23.6(in)-8.9(g)2(:)]TJ /T1_1 1 Tf 0 Tc 1.072 Tw 10.161 0 Td [( A)3.8(n)4.8(a)-3(s)-10.7(t)2.4(a)-3(s)-8.3(iy)3.8(a)]TJ /Span<>> BDC ( )Tj EMC [(M)5.4(.)]TJ /Span<>> BDC ( )Tj EMC [(S)5.6(e)-2.6(n)6.2(i)8.4(n)4.8(a)-14(, )]TJ 0 Tw -10.161 -1.218 Td [(O)-7.4(l)4.7(ga)]TJ /Span<>> BDC ( )Tj EMC [(S)2.1(.)]TJ /Span<>> BDC ( )Tj EMC [(K)12.8(ar)7.7(a)-3(s)4.9(e)-4(v)10.8(a)]TJ /T1_0 1 Tf T* [(A)3.2(u)-6.5(t)-16.7(h)-0.9(o)-1.9(r o)-2.1(f t)-16.7(h)-5.3(e \237)2.2(g)0.5(u)2.4(r)-9.4(e)-13.2(s)2.2(:)]TJ /T1_1 1 Tf -0.005 Tc 0.005 Tw [( A)-1.2(na)-8(s)-15.7(t)-2.7(a)-8(s)-13.3(i)-5.1(y)-1.2(a)]TJ /Span<>> BDC 13.179 0 Td ( )Tj EMC (M.)Tj /Span<>> BDC 1.172 0 Td ( )Tj EMC [(S)0.6(e)-7.6(n)1.2(i)3.4(na)]TJ /T1_0 1 Tf 0 Tc 0 Tw -14.35 -1.218 Td [(W)3.1(r)-48(i)-6(t)-37.4(i)7.1(n)-1.9(g o)-2.2(f t)-16.7(h)-5.3(e t)-15.2(e)-23.9(x)-36(t)-20(:)]TJ /T1_1 1 Tf [( O)-7.4(l)4.8(e)-3.5(g)]TJ /Span<>> BDC ( )Tj EMC [(Y)57.6(.)]TJ /Span<>> BDC ( )Tj EMC [(K)12.9(ar)-20.4(p)1.4(u)4.6(k)5.3(h)6.2(i)8.4(n)-6(, D)-8(i)8.5(n)4.8(a)]TJ /Span<>> BDC ( )Tj EMC [(R)-2.5(.)]TJ /Span<>> BDC ( )Tj EMC [(Y)39.3(ar)-5(u)2.8(l)0.5(l)4.3(i)8.4(n)4.8(a)]TJ /T1_0 1 Tf 0.006 Tc -0.006 Tw T* [(E)11.6(dit)-31.4(i)13.1(n)4.1(g)15(:)]TJ /T1_1 1 Tf 0 Tc 0.776 Tw 3.238 0 Td [( O)-7.4(l)4.9(e)-3.6(g)]TJ /Span<>> BDC ( )Tj EMC [(Y)57.6(.)]TJ /Span<>> BDC ( )Tj EMC [(K)12.8(ar)-20.3(p)1.4(u)4.6(k)5.3(h)6.2(i)8.4(n)-6(, D)-8(i)8.4(n)4.8(a)]TJ /Span<>> BDC ( )Tj EMC [(R)-2.5(.)]TJ /Span<>> BDC ( )Tj EMC [(Y)39.3(ar)-5(u)2.8(ll)4.3(i)8.4(n)4.8(a)-14(, )]TJ -0.006 Tc 0.006 Tw -3.238 -1.218 Td [(T)43.7(a)-10.9(t)-31.2(ia)-6.7(n)-1.2(a)]TJ /Span<>> BDC 2.93 0 Td ( )Tj EMC [(V)47.1(.)]TJ /Span<>> BDC 0.955 0 Td ( )Tj EMC [(G)-1.3(r)-41.3(ig)-8.5(o)-4.7(r)-46.2(y)-5.1(e)-10(v)4.8(a)]TJ /T1_3 1 Tf 0 Tc 0.023 Tw -3.885 -2.436 Td (\255\026\036\031\036\025\034\224 \017\225 \032\026\020\017\022\032\221 \(\ ORCID\))Tj /T1_0 1 Tf 0.08 Tw T* (\234\026\022\017\030\024\r \217\026\017\f \217\026\235\017\f\024\r\017\004\ )Tj /Span<>> BDC ( )Tj EMC (\227 \026\f\f\017\f\021\036\027\021 \022\026\235\036\007\030\t \b\017)Tj 0 Tw (-)Tj 0.56 Tw T* (\030\031\030\020\017\004\036\f\022\017\b \002\024\035\036\027\036\005 \025\ \206\204\211, \r\030\026\004-\022\024\035\024\023\030\024\022\021\024\035\ \024\020 )Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 0 Tw 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\033\030\031\030\213\b)-20.9(\035\231\213\233\t \021\032)50(\b)42(\032\231\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj -51.938 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 23, \023\0221)69(, 202)69(4)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 23, \023\0221)69(, 202)69(4)]TJ /T1_5 1 Tf 25 0 0 25 20.0153 56.0378 Tm (114)Tj ET endstream endobj 1316 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\034\002\220\006)-10(\026)11(\016\001\025\017\001\013\205 \024\220\n\002\025\f\220\025\026)11(\013 \201\220\r\016\002\026\220\n\215\007\025\r \221\002\220\022\r\025\006\ \221\013\007\220\026)11(\016\007\216\001\020\207 )]TJ 0 -1 TD [(\025\006)-10(\007\025\217\001\016\001\220\205\207 \201\220\r\016\002\026\220\n\215\007\ \205\002\001\025\203 \f\025\007\016\222\001\220 \(\221\220\007\025\026\001\ \025\016 \220\006\006)-10(\007\016\201\025\r\013\001\220\016\))]TJ 39.309 1 Td [(Mucosal micr)20(obiota of th)11(e div)12(er)-20(ticula in inflammator)-31(y )]TJ 1.089 -1 Td [(complications of div)12(er)-19.9(ticular disease \(a pilot study\))]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 10 0 0 10 42.5197 724.8299 Tm (\027\026\035\017\004\017\036\n )Tj /T1_2 1 Tf 4.244 0 Td (Synergistetes)Tj /T1_1 1 Tf 0.019 Tw [( )0.5(\(1,5%\) )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 9.134 0 Td [(\r\t\f\024\022\017\n )0.5(\f\024\007\036\030\032\026\027\017)]TJ 0 Tw (-)Tj -13.379 -1.218 Td (\036\n )Tj /T1_2 1 Tf 1.319 0 Td [(V)33(er)-16(rucomicrobia)]TJ /T1_1 1 Tf 0.048 Tw ( \(30,8%\), \026)Tj /Span<>> BDC ( )Tj EMC (\024\002\030\026\036\006 \2254 \b\026\030\026\022\021\036\030\017)Tj 0 Tw (-)Tj -0.036 Tw -1.319 -1.218 Td (\024\r\026\035\f\016 \r\t\f\024\022\017\n \f\024\007\036\030\032\026\027\ \017\036\n )Tj /T1_2 1 Tf 0 Tw [(Actinobacter)-36.9(ia)]TJ /T1_1 1 Tf -0.036 Tw ( \(11,5%\) )Tj 0 Tw 0 -1.218 TD (\(\217\017\f.)Tj /Span<>> BDC ( )Tj EMC (2\202\).)Tj 0.489 Tw T* (\215\030\036\007\f\021\026\r\035\036\027\027\024\f\021\034 \030\026\027\ \t\b \022\035\026\f\f\024\r \002\026\022\021\036\030\017\005 \021\026\022\ )Tj 0 Tw (-)Tj 0.43 Tw T* (\032\036 \f\017\035\034\027\024 \024\021\035\017\004\026\035\026\f\034 \r\ )Tj /Span<>> BDC ( )Tj EMC (\004\036\021\t\030\036\b \017\f\f\035\036\007\024\r\026\027\027\t\b )Tj 0.805 Tw 0 -1.218 TD [(\007\017\r\036\030\021\017\022\031\035\026\b. )0.6(\212\024\n\017\027\017\030\031\033\013\017\n\017 )0.5(\022\035\026\f\f\026\n\017 )0.5(\002\t\035\017 )]TJ /T1_2 1 Tf 0 Tw 0 -1.218 TD [(Clostr)-36.9(idia)]TJ /T1_1 1 Tf 0.736 Tw [( )0.5(\(34,9\22666,3%\), )]TJ /T1_2 1 Tf 0 Tw 11.251 0 Td (Bacteroidia)Tj /T1_1 1 Tf 0.736 Tw [( )0.5(\(13,3\22642,7%\) )]TJ 0 Tw -11.251 -1.218 Td (\017)Tj /Span<>> BDC ( )Tj EMC /T1_2 1 Tf 1.267 0 Td [(Gammap)46(ro)13(teobacter)-36.9(ia)]TJ /T1_1 1 Tf 0.516 Tw ( \(3,8\22614,7%\). \210\002\030\026\036\006 \2254 )Tj 0.777 Tw -1.267 -1.218 Td (\024\021\035\017\004\026\035\f\016 \r\t\f\024\022\017\n \f\024\007\036\030\ \032\026\027\017\036\n )Tj /T1_2 1 Tf 0 Tw [(Actinobacter)-36.9(ia)]TJ /T1_1 1 Tf ( )Tj -0.023 Tw T* (\(10,3%\), \026)Tj /Span<>> BDC ( )Tj EMC (\2252 \017)Tj /Span<>> BDC ( )Tj EMC (\2253)Tj /Span<>> BDC ( )Tj EMC (\227 )Tj /T1_2 1 Tf 0 Tw [(V)33(er)-15.9(rucomicrobiae)]TJ /T1_1 1 Tf -0.023 Tw ( \(8,2% \017)Tj /Span<>> BDC ( )Tj EMC (30,6%, )Tj 0 Tw T* (\f\024\024\021\r\036\021\f\021\r\036\027\027\024\).)Tj 0.354 Tw 0 -1.218 TD (\210\f\027\024\r\027\031\033 \n\026\f\f\031 \n\017\022\030\024\002\017\024\ \021\t \f\024\f\021\026\r\035\016\035\017 \023\030\036\007\f\021\026)Tj 0 Tw (-)Tj 0.372 Tw 0 -1.218 TD (\r\017\021\036\035\017 \f\036\n\036\005\f\021\r )Tj /T1_2 1 Tf [(Lachnospiraceae, R)22(uminococcaceae,)]TJ /T1_1 1 Tf 0 Tw ( )Tj /T1_2 1 Tf 0 -1.218 TD [(Bacteroid)26.1(aceae )]TJ /T1_1 1 Tf 6.39 0 Td (\017)Tj /T1_2 1 Tf 0.212 Tw /Span<>> BDC ( )Tj EMC [(Enterobacter)-36.9(iaceae. )]TJ /T1_1 1 Tf (\210\027\017 \024\002\027\026\030\031\032\017)Tj 0 Tw (-)Tj 0.047 Tw -6.39 -1.218 Td [(\r\026\035\017\f\034 )0.5(\r\024 )0.5(\r\f\036\b )0.6(\017\f\f\035\036\007\031\036\n\t\b )0.5(\024\002\030\026\006\026\b, )0.6(\024\007\027\026\022\024 )0.5(\017\b )0.5(\f\024)]TJ 0 Tw (-)Tj 0.036 Tw T* (\007\036\030\032\026\027\017\036 \r)Tj /Span<>> BDC ( )Tj EMC (\027\017\b \f\031\013\036\f\021\r\036\027\027\024 \r\026\030\034\017\030\ \024\r\026\035\024 \(\217\017\f.)Tj /Span<>> BDC ( )Tj EMC (2\207\). )Tj 0.148 Tw T* (\025)Tj /Span<>> BDC ( )Tj EMC (\n\027\024\020\024\004\035\036\027\027\t\n \f\036\n\036\005\f\021\r\026\n\ \021\026\022\032\036 \f\035\036\007\031\036\021 \024\021\027\036\f\021\017\ )Tj /T1_2 1 Tf 0 Tw T* [(V)33(er)-16(rucomicrobiaceae)]TJ /T1_1 1 Tf 0.244 Tw ( \017)Tj /Span<>> BDC ( )Tj EMC /T1_2 1 Tf 0 Tw ([Tissierellaceae])Tj /T1_1 1 Tf 0.244 Tw (, \022\024\021\024\030\t\036, \024\007)Tj 0 Tw (-)Tj T* (\027\026\022\024, \024\021\f\031\021\f\021\r\024\r\026\035\017 \r)Tj /Span<>> BDC ( )Tj EMC (\027\036\022\024\021\024\030\t\b \024\002\030\026\006\026\b \(\230\026\002\ \035.)Tj /Span<>> BDC ( )Tj EMC (4\).)Tj 0.215 Tw T* (\215\024 \007\026\027\027\t\n \035\017\021\036\030\026\021\031\030\t, \212\ \207 \f\024\023\030\024\r\024\032\007\026\036\021\f\016 \031\r\036\035\017\ )Tj 0 Tw (-)Tj 0.479 Tw T* (\004\036\027\017\036\n \004\017\f\035\036\027\027\024\f\021\017 \f\036\n\ \036\005\f\021\r\026 )Tj /T1_2 1 Tf 0 Tw [(Enterobacter)-36.9(iaceae )]TJ /T1_1 1 Tf 0.108 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\022\017\001\036\004\027\017\022\036 [17]. \200)Tj /Span<>> BDC ( )Tj EMC [(\023\024\035\027\024\n \f\024\024\021\r\036\021\f\021\r\017\017 )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC (\007\026\027\027\t\n )Tj 0.221 Tw T* (\235\026\022\021\024\n \r\024 \r\f\036\b \017\f\f\035\036\007\024\r\026\027\ \027\t\b \024\002\030\026\006\026\b \024\021\n\036\004\026\035\017 )Tj 0.383 Tw T* [(\027\026\004\017\021\036\035\034\027\024\036 )0.6(\f\024\007\036\030\032\026\027\017\036 )0.5(\220\027\021\036\030\024\002\026\022\021\036\030\017\005 )0.5(\022\031\035\034\021\031)]TJ 0 Tw (-)Tj 0.067 Tw T* (\030\026\035\034\027\t\n \n\036\021\024\007\024\n \(\230\026\002\035.)Tj /Span<>> BDC ( )Tj EMC (2\) \017)Tj /Span<>> BDC ( )Tj EMC (\f \023\024\n\024\013\034\033 \f\036\022\r\036\027\017\030\024)Tj 0 Tw (-)Tj T* (\r\026\027\017\016 \020\036\027\026 16S \030\217\203\025 \(\230\026\002\035\ .)Tj /Span<>> BDC ( )Tj EMC (4\).)Tj 0.288 Tw T* [(\215\030\017 \026\027\026\035\017\036 \n\017\022\030\024\002\017\024\021\ \t \r\024\f\023\026\035\036\027\027\t\b )0.5(\007\017\r\036\030\021\017\022\031)]TJ 0 Tw (-)Tj 0.129 Tw T* (\035\024\r \027\026)Tj /Span<>> BDC ( )Tj EMC (\031\030\024\r\027\036 \030\024\007\024\r \024\021\n\036\021\017\035\017\ , \004\021\024 \r)Tj /Span<>> BDC ( )Tj EMC (\021\030\036\b \024\002\030\026\006\026\b )Tj 0.36 Tw T* [(\(\2252, )0.5(\2253, \2254\) \030\026\r\027\024\r\036\f\017\036 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 13.377 0 Td [(\n\017\022\030\024\002\027\024\n )0.5(\023\036\005\026\032\036 )]TJ 0.25 Tw -13.377 -1.218 Td (\002\t\035\024 \f\017\035\034\027\024 \f\n\036\013\036\027\024 \r)Tj /Span<>> BDC ( )Tj EMC (\f\021\024\030\024\027\031 \024\007\027\024\020\024 \030\024\007\026, \004\ \021\024 )Tj 0.782 Tw T* (\023\024\007\021\r\036\030\032\007\026\036\021\f\016 \r\t\f\024\022\017\n\ \017 \027\026\004\036\027\017\016\n\017 \017\027\007\036\022\f\026 )Tj 0.046 Tw T* (\221\017\n\023\f\024\027\026 \(\230\026\002\035.)Tj /Span<>> BDC ( )Tj EMC (3\). \230\026\022, \r)Tj /Span<>> BDC ( )Tj EMC (\2252 \007\024\n\017\027\017\030\031\033\013\017\n \030\024\007\024\n )Tj 0 Tw T* (\002\t\035 )Tj /T1_2 1 Tf 2.173 0 Td [(P)18(ar)-42(vimonas )]TJ /T1_1 1 Tf 0.343 Tw 5.129 0 Td (\(21,3%\). \213\007\017\027\f\021\r\036\027\027\t\005 \r\017\007 \220\021\ \024\020\024 )Tj 0.096 Tw 15.943 40.187 Td (\030\024\007\026)Tj /Span<>> BDC ( )Tj EMC (\227 )Tj /T1_2 1 Tf [(P)18(ar)-41.9(vimonas micra)]TJ /T1_1 1 Tf /Span<>> BDC ( )Tj EMC (\227 \220\021\024 \020\030\026\n\024\021\030\017\006\026\021\036\035\034\ \027\t\036 )Tj 0.232 Tw T* (\026\027\026\220\030\024\002\027\t\036 \022\024\022\022\017, \022\024\021\ \024\030\t\036 \004\026\f\021\024 \024\002\027\026\030\031\032\017\r\026\ \033\021\f\016 )Tj 0.259 Tw T* (\023\030\017)Tj /Span<>> BDC ( )Tj EMC (\f\n\036\001\026\027\027\t\b \026\027\026\220\030\024\002\027\t\b \017\027\ \235\036\022\006\017\016\b, \027\026\023\030\017\n\036\030, )Tj 0.046 Tw T* (\026\002\f\006\036\f\f\036 \002\030\033\001\027\024\005 \023\024\035\024\ \f\021\017 [18]. \230\026\022\017\n \024\002\030\026\024\n, \024\002)Tj 0 Tw (-)Tj 0.061 Tw T* (\027\026\030\031\032\036\027\017\036 \220\021\017\b \002\026\022\021\036\ \030\017\005 \r)Tj /Span<>> BDC ( )Tj EMC (\r\024\f\023\026\035\036\027\027\024\n \007\017\r\036\030\021\017\022\031\ )Tj 0 Tw (-)Tj 0.121 Tw T* (\035\036 \026\022\024\027\024\n\036\030\027\024, \027\024 \r)Tj /Span<>> BDC ( )Tj EMC (\024\f\021\026\035\034\027\t\b \024\002\030\026\006\026\b \024\027\017 \ \035\017\002\024 )Tj 0.186 Tw 0 -1.218 TD (\024\021\f\031\021\f\021\r\024\r\026\035\017 \(\2251 \017)Tj /Span<>> BDC ( )Tj EMC (\2254\), \035\017\002\024 \f\024\007\036\030\032\026\035\017\f\034 \r)Tj /Span<>> BDC ( )Tj EMC (\027\036)Tj 0 Tw (-)Tj 0 -1.218 TD (\002\024\035\034\001\024\n \022\024\035\017\004\036\f\021\r\036 \(1,3% \r\ )Tj /Span<>> BDC ( )Tj EMC (\2253\).)Tj 0.096 Tw T* (\200 \024\002\030\026\006\026\b \2252 \017)Tj /Span<>> BDC ( )Tj EMC (\2253 \r)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\034\001\024\n \022\024\035\017\004\036\f\021\r\036 \023\030\ \017\f\031\021)Tj 0 Tw (-)Tj 0.428 Tw T* (\f\021\r\024\r\026\035\017 \002\026\022\021\036\030\017\017 )Tj /T1_2 1 Tf [(Akk)17(er)-14(mansia muciniphila )]TJ /T1_1 1 Tf 0 Tw (\(8,1% )Tj 0.093 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (30,8%, \f\024\024\021\r\036\021\f\021\r\036\027\027\024\), \023\030\017\004\ \036\n \r)Tj /Span<>> BDC ( )Tj EMC (\2253 \220\021\024\021 \r\017\007 \007\024)Tj 0 Tw (-)Tj 0.15 Tw T* (\n\017\027\017\030\024\r\026\035 \r)Tj /Span<>> BDC ( )Tj EMC (\n\017\022\030\024\002\017\024\021\036 \007\017\r\036\030\021\017\022\031\ \035\026. \223\030\036\n\036\030\027\t\005 )Tj 0 Tw 0 -1.218 TD (\030\024\f\021 )Tj /T1_2 1 Tf 0.319 Tw 2.371 0 Td (A. muciniphila)Tj /T1_1 1 Tf ( \023\030\017\r\024\007\017\021 \022)Tj /Span<>> BDC ( )Tj EMC (\007\036\020\030\026\007\026\006\017\017 \n\031\006\017)Tj 0 Tw (-)Tj 0.252 Tw -2.371 -1.218 Td (\027\026, \027\036\024\002\030\026\021\017\n\024\n\031 \023\024\r\030\036\ \032\007\036\027\017\033 \021\022\026\027\036\005 \024\030\020\026\027\017\ \n\026, )Tj 0.004 Tw 0 -1.218 TD (\r)Tj /Span<>> BDC ( )Tj EMC (\004\026\f\021\027\024\f\021\017, \f\035\017\017\f\021\024\005 \024\002\ \024\035\024\004\022\017 \021\024\035\f\021\024\005 \022\017\001\022\017\ , \f\023\024)Tj 0 Tw (-)Tj T* (\f\024\002\f\021\r\031\036\021 \r\t\007\036\035\036\027\017\033 \220\027\ \007\024\021\024\022\f\017\027\026 [19].)Tj 0.67 Tw T* (\200 \024\002\030\026\006\036 \2254 \024\021\n\036\004\036\027\024 \r\t\ \f\024\022\024\036 \f\024\007\036\030\032\026\027\017\036 )Tj /T1_2 1 Tf 0 Tw T* [(Bi\233dobacter)-36.9(ium)]TJ /T1_1 1 Tf 0.089 Tw ( \(10,3%\), \022\024\021\024\030\t\036 \031\f\021\031\023\026\033\021 \r\ )Tj /Span<>> BDC ( )Tj EMC (\022\024\035\017\004\036)Tj 0 Tw (-)Tj 0.123 Tw T* (\f\021\r\036\027\027\024\n \023\035\026\027\036 \035\017\001\034 )Tj /T1_2 1 Tf 0 Tw (Bacteroides )Tj /T1_1 1 Tf 0.123 Tw 14.335 0 Td (\(40,1%\). \203\036\f\n\024\021\030\016 )Tj 0.153 Tw -14.335 -1.218 Td (\027\026)Tj /Span<>> BDC ( )Tj EMC (\017\r\036\f\021\027\t\036 \002\035\026\020\024\021\r\024\030\027\t\036\ \220\235\235\036\022\021\t \002\017\235\017\007\024\002\026\022\021\036\ )Tj 0 Tw (-)Tj 0.111 Tw T* (\030\017\005 \027\026)Tj /Span<>> BDC ( )Tj EMC (\007\024\030\024\r\034\036 \004\036\035\024\r\036\022\026 [20], \017\n\036\ \033\021\f\016 \f\r\017\007\036\021\036\035\034)Tj 0 Tw (-)Tj 0.192 Tw T* (\f\021\r\026 \021\024\020\024, \004\021\024 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\210\212 \017\b \f\024\007\036\030\032\026\027\017\036 \r)Tj /Span<>> BDC ( )Tj EMC (\022\017\001\036\004\027\017\022\036 )Tj 0.093 Tw T* (\023\024\r\t\001\026\036\021\f\016 [21], \026)Tj /Span<>> BDC ( )Tj EMC (\023\030\017 \f\017\n\023\021\024\n\026\021\017\004\036\f\022\024\005 \027\ \036\024\f\035\024\032)Tj 0 Tw (-)Tj -0.044 Tw T* (\027\036\027\027\024\005 \007\017\r\036\030\021\017\022\031\035\016\030\027\ \024\005 \002\024\035\036\027\017 \(\221\203\212\207\) \022\024\030\030\ \036\035\017\030\031)Tj 0 Tw (-)Tj T* (\036\021 \f)Tj /Span<>> BDC ( )Tj EMC (\021\016\032\036\f\021\034\033 \f\017\n\023\021\024\n\026\021\017\022\017\ [22].)Tj 0.137 Tw T* (\222\r\036\f\021\027\024, \004\021\024 \023\030\017)Tj /Span<>> BDC ( )Tj EMC [(\007\017\r\036\030\021\017\022\031\035\017\021\036 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC (\221\203\212\207 \r)Tj /Span<>> BDC ( )Tj EMC (\235\036\022\026\035\034)Tj 0 Tw (-)Tj 0.416 Tw T* (\027\024\005 \n\017\022\030\024\002\017\024\021\036 \f\027\017\032\036\027\ \024 \f\024\007\036\030\032\026\027\017\036 )Tj /T1_2 1 Tf 0 Tw [(Clostr)-36.9(idium)]TJ /T1_1 1 Tf ( )Tj 0.087 Tw T* (\022\035\026\f\021\036\030\026 IV, \022)Tj /Span<>> BDC ( )Tj EMC (\022\024\021\024\030\024\n\031, \r)Tj /Span<>> BDC ( )Tj EMC (\f\024\024\021\r\036\021\f\021\r\017\017 \f)Tj /Span<>> BDC ( )Tj EMC (\f\024\r\030\036\n\036\027)Tj 0 Tw (-)Tj 0.173 Tw T* (\027\024\005 \f\017\f\021\036\n\026\021\017\022\024\005, \024\021\027\024\ \f\016\021 \027\036\f\022\024\035\034\022\024 \030\024\007\024\r \f\036\n\ \036\005)Tj 0 Tw (-)Tj T* (\f\021\r\026 )Tj /T1_2 1 Tf 2.076 0 Td [(R)22(uminococcaceae)]TJ /T1_1 1 Tf 0.089 Tw [(, )0.5(\r\022\035\033\004\026\016 )0.6(\023\030\024\021\017\r\024\r\024\f\023\026\035\017\021\036\035\034)]TJ 0 Tw (-)Tj 0.114 Tw -2.076 -1.218 Td (\027\t\005 \017)Tj /Span<>> BDC ( )Tj EMC (\002\031\021\017\030\026\021-\023\030\024\007\031\006\017\030\031\033\013\ \017\005 \r\017\007 )Tj /T1_2 1 Tf 0 Tw [(F)15(aecalibacter)-36.9(ium )]TJ T* [(p)46(rausnitzii )]TJ /T1_1 1 Tf 0.151 Tw 4.493 0 Td [([23]. )0.5(\200)]TJ /Span<>> BDC ( )Tj EMC 3.349 0 Td [(\017\f\f\035\036\007\024\r\026\027\027\t\b )0.5(\007\017\r\036\030\021\017\022\031\035\026\b, )0.5(\027\026)]TJ 0 Tw (-)Tj 0.137 Tw -7.842 -1.218 Td (\023\030\024\021\017\r, \004\017\f\035\036\027\027\024\f\021\034 )Tj /T1_2 1 Tf 0 Tw [(R)22(uminococcaceae)]TJ /T1_1 1 Tf 0.137 Tw ( \002\t\035\026 \r\t\f\024\022\024\005 )Tj -0.07 Tw T* (\(8,8\22625,5%\), \026)Tj /Span<>> BDC ( )Tj EMC /T1_2 1 Tf 0 Tw [(F.p)46(rausnitzii)]TJ /T1_1 1 Tf -0.07 Tw ( \r)Tj /Span<>> BDC ( )Tj EMC (\027\026\004\017\021\036\035\034\027\024\n \022\024\035\017\004\036\f\021\ \r\036 )Tj ET q /GS0 gs 453.543294 0 0 185.2568375 42.5196838 122.6975387 cm /Im0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf -0.029 Tw 9 0 0 9 42.5197 111.7959 Tm (\022\t\217\210\b\002\220 2.)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf ( \207\n\030\031\032\204\026\021\025\031 \(%\) \f\025\023 \(\201\) \025)Tj /Span<>> BDC ( )Tj EMC (\t\031\003\031\017\t\024\027 \(\213\) \027)Tj /Span<>> BDC ( )Tj EMC (\027\n\t\033\026\023\031\021\021\020\004 \030\025\027\031\032\024\025\013\ \205\023\026\004. \217\026)Tj /Span<>> BDC ( )Tj EMC (\205\032\n\027\021\031 \f\025\023 \033\n\013\026\016\026\021\020 \024\026\ \013\t\n\021\020 \t)Tj /Span<>> BDC ( )Tj EMC (\n\024)Tj 0 Tw (-)Tj 0 -1.2 TD (\021\n\t\025\024\031\023\022\021\020\003 \t\n\030\031\032\204\026\021\025\ \031\003 \027\020\001\031 1%. \217\026)Tj /Span<>> BDC ( )Tj EMC [(\205\032\n\027\021\031 \t\031\003\031\017\t\024\027 \033\n\013\026\016\026\ \021\020 )0.6(\024\n\033 10 \021\026\025\005\n\023\031\031 \003\021\n\202\n\006\025\t\023\ \031\021\021\020\004 \t\031\003\031\017\t\024\027.)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf -0.022 Tw T* [(F)-16(igure )0.5(2)15.9(.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf [( R)21(elativ)13(e abund)26(ance \(%\) of ph)12(yla )0.5(\(A\) and families )0.5(\(\213\) )0.5(in in\234amed div)12.9(er)-40(ticula. A)14(t the ph)11.9(ylum lev)13(el, the tax)10(a with av)13(erag)12(e )]TJ 0 Tw T* [(relativ)13.1(e abund)26(ance abov)13.1(e 1% are displayed. A)14.2(t the family lev)13.1(el, the top ten tax)10(a are e)-15(xhibited.)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\033\030\031\030\213\b)-20.9(\035\231\213\233\t \021\032)50(\b)42(\032\231\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj /T1_4 1 Tf 25 0 0 25 504.6396 56.0378 Tm (113)Tj ET endstream endobj 1317 0 obj <>stream Adobed     '$''''$25552;;;;;;;;;;   %%#(((((#,0000,7;;;7;;;;;;;;;;   %%#(((((#,0000,7;;;7;;;;;;;;;;   %%#(((((#,0000,7;;;7;;;;;;;;;;<""   :OTS!QRU "#$%&'()*123456789:ABCDEFGHIJVWXYZabcdefghijqrstuvwxyz w!1AQaq"2BRCDbScd#r $%&'()*3456789:EFGHIJTUVWXYZefghijstuvwxyz?:J_h]GҺi5*谲[N֤o c_V+̎iTvXBi.G+q@SzZokouuPꮦ;(IbhUQ֜/^zzEU1MUET]m4b(2W-tZ_X.Om]j(;٧zx@< WT]eUvxP~JꞐꛫ@M3`oUzb+$u/*NߩOR/m/BT]U5QR.%X ;-2ΫW\:JTzQY6:FgU֖UD+> ETF<0^(Zvogik\JhVXQr:nxcsoR}UeUz8:()Xr.I)l[`ѡB*4!B£Bpej{B!MUdEH6,K[jХq:)̽+^)y vy v=}f7һ2z|Y槴.qCY槴.qB޾fh{+^(/JW}pej{B0ej{B!}f7һԽ)S|e%!S4hA6 m4!QB2C&>8!G^4M رk&g]Meo6H3x>80}H2q?]{x _qYZ /2yUOff}H2q?`d\uV̯z?* 80}H2q?]{k:K+AeWV?2Ё-C@aЁ';G4(@B*hv,&\$Hͮkek]J2m='U7t.k \$Hu|ƨ6I~ 'U7t.k \$Hu|ƨ6I~ 'U7t.k \$Hu|ƨ6I~ 'U UBKF[ȚTchBBB$*IczyʻIK3&6ЭvҧJJAuw5/I,qpƒ$jOW35A֕A֕CP2HTk i!RK}1umm: B8X8cI X`ݫ`koq`l}<:Ҿw5i"Bmt1 *0hr4wzLM4Ѭ ]ƥMQ.jPTKf*KЪ^Ժm:=FXU5WUn[Q ~v߫%M5Z:8ynҺ^WncT2-V*cUUUKؖ=Z)+.VE)SԚk\Dc s@eSlUQCGSrhSmtn笪#UiWM7Si(S1EenlSCN%RI4t1QQ FThPPѡʾ~3 \^sgz)v6X/2L"FʇR]*e=z:JmkkW=zizEima]Z?1kqqvx8GA4ti2u+/]}]FPE y[_Pz9 3 \^| '@rt {ywEu /HPE}g@獦qKCQF4 ЁѰ(ܭGAPhУJe8̎$Z5caE٤f b,EUTqM|PE Ӵ{]mEVuܛ(pz7GN)&.Y\>4#!PBpPB3%Aɂ{=]asͮ_>IRggCƞw+g!ѮUM+J(UYٻkgTM gaX{K"ʏv_blHD{>]a0SOgҋ;ϒKԯ!W$aX{K"W4{(ü`ϥXw$.SW ~Y0=G%h{>]aQsJ2QLd(T#ѣ B2 <UJOJ=)jWMh)KԒĊ0=G%uWD TT'4ՂNK1'/)'3Sf_{}>}wa;alv+-¬scyWTYWU$O}>|E>G¾!ul=l̊1tScywzE> )>}o <.W2+;ʽM.Ul(xWJUʷª+n<Ǹ:?Ghnj *hzM PjtSK*6?ʎRNRӤZ$Q-[tUkr *{?]!_0EOg+' akY{RWygȋ˼jHHWS ->?D^]T"DGT(B`HW8!l(Y5G", 8"ͧ.hˆ 6hѣ("Lh]gPc ΩE*Uda:Zu%r^uGVtwۣ6~ zU1 30Gsުi}Hvjt޻M]i&#H]iWꥋҴm7B4 Φ7JҬUUdT05Fs@쨲coXIjҗص)MGTUkcEnwwSJS+mқŽfgRg휎XGGuOLl\u3_ #oD>U"KD>"LQiGZQ|(gC3S3mi?FO_i_¼F=M_M_e 0Mm()6MMm()z—ض}*絙bcJ93G& 0{/ks1rf6Lq/k<G&ch{/ksUd{d{TD eSkoyMOݯ3J)i7fiU&X@*yvHJ>5"#})L/7sv-+U^zw[?{tv7t}~ҵLѪcۭԱmHsmEϳm$`,g%\X|+v}F}r7>ÒӕSJz "Ӆ>jyO_!z$Z5|)yJSڏR* O6~RO6~R%6,J~SG;/6_"Dhge&H=x⫞/lR1*UsmJF!iSN)WW>bO6_Ru%ϘMڇP4m,!>W"J xASCMI*hzM MF+Ҿb:GUʎtUkrjei+z 'ғ=lwZ=YE#:(0#cBB enCB $6iE^$iQhoXhZUnm8FSoD>U"{ګktʮƩ*1~icꭿQ%)Jm#)ĘvY慗{W2<ӧ[-icꭿQ%)Jm#)ď5]z<вj^R`t"Xo:~,}U ٥6x JECB:Q/vB꾊Yꅗ{W2'eҏSF4DVOi4Ԛ,e4T봟L[c(sZO`&m<)K4o5~ѾZK$L60Mm()* "/PS&:5M߅/mkUF#o> z<< lO`>JY(0}"!Flwmm)iMٚUfYi7fi<+2*yvHJF>5"#})L7sv-+SӾZOanN״f֏{tV< iҪ6tMuxK;iSUWiK.6)"3ի]Sv{x+Im PdƺԶڕK 6LǷ[ͶjXyI/X>c=~IZX/NK,JQas+eLx=Q6E >}BHk_)_ @=^l/Ҫ:yJͮ_>vͮ_>Id>ҟM>Y}"Aǡ <W<^)?Q)bV%'%B-榝S9.|ğlHNKMڇPhY.CHdO@^U>T;YCcT3IOMWtUkrGS~lW]_M66Lrl Wzh+:G64u8j VUtm &hY0pw;iyi+z uTW>ing*!Uvp@5͍#kImGP4a:4{;*ENV*hNRHt^SMRn7,Eivi:)>u;I Gtd DU:6Tr4qpEKQ(w(VZQK$h)3_yNжޫJV8} n괯g>YiFU.k-(ʥ|Qji=<;78} n괯cжޫJVs଴*IB%ݕ.y({LS-7ҿBۣz+YσEchVؚ[2 2By5n.m:' Y+:f0X:8:7KjBڽ(gTJ.-|5-oɭ#qbM֑Wuݿ*LKJ+_5OUgyZz?EP9k|DMi"o&ŝAv1斕Wk=QeTTM֑[&kH]woJSii^~ki5OUg.9hAB )n2 e JبchѣejپI]NzaԆTݧT+}Zsb^N+6R^hh ?Mٚf@ ?MiZӒh'7Ijx@Ӫ ާZ]vR*vWvQƥt AmK%i6UP]o^0w*8PֲEVVjᬮ+z=UEJM.VM\½څEuWirJ^-m˃% Ҫt*[W蛮5IKo6٩cۭȐI/X>g=~IZX/NK,JQ~a+eLGϴڞS^(Sz "ѯf|)yJSڋ揱+-ȽOg)JM,~_a6_RH{2/Izx=șHTCJOCR1+ȪIG#xo4ҟxs#R_Ru#ϘK~IRl*) M4bQGFthРL MKXj-eV}5e4mz:m+KJITIV}ZW| MC1}1%^ZyONqU>9ʰ| MC1}0orUꘗIV}%Zs`3W-xhc PCbB4(Pwec=ө]Pmd*r-xGi4yli\ W;%c9E-跡xgEMMIeMJkgzZL:i[Uh4{;]X%d(kC楫gZh֕ZhV9mbZNɅ+Fioma]4x47MFLnYfhj5aM e,ѐh4cⱴ(,A#ARVTv;'[1Zu"=*Q 73Q}-,+˅5SeT5掗zS<;|$v(>>GW/!kj}K5掗zSh~3A#AʂGbj}ڵ5>GK=~4tsٸ}V~u~1ThEA4ry.T_{ǶݢdžԳPoG—GK=~.?ךfѢٶmR_Ff=Xig_O|#N_,7&YUvBy(!PУKhQGb iEN/|G@|ESJ]u**k.mjt&V5M:K=;*_ E1iQVo?\j_kfGz4狼ok4狼ok` G`xvH7W1枝m~Q枝m~SLQVoi[_;7<Ӿ<ӾiEB91(c(PhPC!B$=M$^v:—oin[nͶ5*fݙVoXSjEFR1& 쫢EtRMILkֺ-T>GJ;[zY~ӁUY;6NI`Ko6Fno"Cm$hz,QVdQ}>r1r3}{{ʼts|9W(*kH kH Ǜx}.}b}g:J=ÕyG^^r)"Qu*>}BH֭tisyJb"dQqpbctl  e c658La4kE،vL_zSڍFDRLJ=ÕyMk]VU]PzJQ(#( (4(ѣGC{G1]mHoQZ+Z:z4.C.M:ں)miJҤJJL>kC.ʼ 3F=H1 R9EkNv$_IVUkC*ʼ>v"ҁG1!Zws&PJr)PJr)G1q1RzY&"`ABgH-a6Ҋ۩/Vci(<B\h.R}uAA \G8COΎG?P3Hw;scHw ާi=^FuhU=oET4: J6iDwDK:eUvTZ;+.fҺ"81k5WUݫnX4c(YjKꞓ]vNһXBI=[4t4vUқI:k`7,Jy =;K:Rs=hjoY=:+г;Ig| [oUxϵW5 ٸ}R~O3fH^YDIQSʏMv)/Em%53ͥՏGU>ZQFo5~Œ_,*IN/|G@|Gۍ'># >"M'qү|ſ_ E9qoo2QNi}&+|(4aڮDku7;o/GCENn׫7lS'D7fkU3'*yvHJF>5"#})L7sv-+S4}~ҵ|&h`ժ G EyMj'cXX)Mi4UeE:U]ݟ * q<WoXY봵U]NuIuFÄ-)ZFj4C*Mq-TQi^)SkgM-ՇkRk^aizUNe-5-Ez]TÛ:TOd'hEBUUciEiUt5RN# 6mnۮj7Et;8i 4UgFeiDՒz{;:V*O>Rފ+֗EETԡMꭾmfXQegr4SB [n[ml[uKmo|3?Y19)g~Ҿ[. kl׷f0 /WZi~J:# nRҲ~i|gD.7JO!u!UouxOVKŦ|Qli/ 5 gҐ=7e^Gj(yN+/q|"?FIX)&bz~)3F c2[|]^8ec=/(VF9):Ak]cUOzODB\^ h]gPCwuOx(1j44~ |TE>xGi;`64y}4uVvi6U^vUi5M'vkzS8ƺʵYZQ]VJҙjJ֛.k+;VTګGL9QiF6uUMԝګ}1]oE-**袛*h6rSL;JvjR ^iLm!^i J֧n-ZT *Zkd uXuSFӭ4*ƭ.ʺ-MWUw-C6:Eeqhw,ObJWLVӂMRR'-…/[H/=:+гz=uWgwE@gW¼Fk9m+ΪVV}تEhnfꐽ~17<%GmO*"JڞT}kfYI}-ɴ yACTr4((vX"`gꝊ19WTh3v[˹i]c7Ϋ7MT 8kbKLHo~6dvX7G`y֫mνKjڶ>ck-7"տ)ZoE~S1C#ET2;]ZjsRڶ>avKMHo<~-}[6~u kBC"ԈX7]Ƕ~^M[l|[1斛kߔ-3"տ)£?MiZ֪ ;iauGEꖉiIVSJ)֋+Gk[(ND NFvTSO봥*Sm%Lꓰ4iZ=5Eҥ*TںRK:LĠ(Ƿ[ͷcۭQ9)g~b6rSטhg-|]^-9#R׷f3%n`]Ү8uIXu'G#^@ݣ啞 4>YYd"[GR_'?Ґߪӷki'%b>^->kgŧph1k*7d;AYW!ڿx /QEiex2MEWI6P=UfIF c2[|uxL`펔vZ. lt|g[uBS^>QR[u?m?`xKzIp=5r+z v ?:9<^#g@#5͍#k:mkt{{+;="ڛKWc]=W=UJn]שOiZuS鵪ҫJ*u4h)cFU>ʼnT9n+KeU5*ЪI% !kwH*ZԪvSk)}&4iO!nY/=:+гz=uWgwE@gW¼Fk>U^"mU+@ Cpc6nTٸ}Ra*;jyQTvS-}g%h}er/䞍M?&SJf%zL6>6:HbW3d_mle~ʞB]Ck\[S/vc-|5׌ezɶ $WmCICv.c;{S'C5fj՛6~5jM?MiZӾZOanJ״` 0ת %64)v*ڝJ9v=qkgGSmk{K[=Սji9L½J*,hkBԒ{HJK-47^apGи;j֔ߩ{*q[֕*)Sw,T)ԓo 2UݼMq9Ʃd@2Xy5,{uy*#g%=y~FJz崿 e$jZdٌz{KvUְ=']Ү8+}Dk|fG+=~dBhJC~"[GRZv-m>Wd ZgŧscLxQc==7e^h1k*5R>[W!^@("(#dE(AҒm'z-ꫪ4mZ&3%ZWx~G`EpJ;z-Q{NJ|$*ΐ[u?m?%S^>Q&x;'|x0i\;,,ΥhZVhT,/SilJgSMuTx\yu"ˢJ,mʫM6f]5bҴ-R{QZFjFJڛKjmTISS %Ґꍻڪl/ݢJ0(RnYfhjoY=:+г;Ig|^#5km*ZYYb~17Bl> 0`<*;jyQ)81Y C0bh24q!EE̖4lziYShs:n\ҫiSTm]aiY$d7K4^$Y8Hw"ZC[QZu=FXZw?_ ,4ċ'i^$Y8Hw :ڎ>qaiY$:ӿ(Hׯ.dy q"Hw k>>p {̍ΰ ,< N#PUshlTi\U!`ۨ{N ڴy >(VӯsnL[--|5ŷݷO E9r~"5 >YYHݣ啞 ?FO!u!UR} ) ; z\-3彧scLxQc==7e^h1k*5R>[WD+1("(#dE(AҒm'z-ꫪ4mZ|. mֿ1_:Q>3h2ҎEmnӒ OzOEQmIG rw׃=Ox(!'vC~ fHQwyli\>zN*,&Xu·VS}ڪny5-H4]"EzVE(;+WSvuЪWwz4볯zET]V*\keW)(ꎒv#uUJZi:nJ"fy 3rϴ\Gu,CjoYn|'Y,WfoUxϵW5 ٸ}R~O3fH^YDIQSʏOvQ 7a[{JXI [ O?,> j%9If e†TWభm *m UCF2 KG$p[ +%Bz]항jUxN|}}SUNֵk? _gר$l$le殅j}!R o2xW'H%ɜ_QќInQќIn] Bdi1OJ9޿^8ݳ8ݳH-? _c̞-#&o$ebPDAѹAУ(c`Q$UEeMZv)N5fE~C7fkUfmcV%uggaa/g1fUDǐ,3}|px ? "8 ? "~ y*cyU> c͟#c͟'ǐ&iieoeidҋJ*DINy[K-*ދ{:4mU]J[]Ko6Fno#Dl䧯1шO^c=uxLK^ݘ̖1O@i~ʺ{KzUְ='aԟyvToHݣ啞 ?FO!u!UR} ) ; z\-3F|Z|(1vֲJCxC޵zR˩-C -v_](#dE(AҒm'z-ꫪFZWdk_/(]~G`E7oiOY nX}ՇJ$З'x<'i6|QzU|56ʵ |##HuUk]mMVz=uWg_=  dT(QF:'BŲ0&1AX'1.UmcUI-=[53fH^689!DD:Œuk/\Ն{Bw*6|>-=['e2?OvQ 7a[{F]ކ-oZ~Zџܵ~~h\z<60<`ne4h B +GpSUfQ%[a{EzN ll讚R+5|-MxKi֎Zxk~Nm~iUJ%U+C̿Hnp]<ƍlGoߎ_H XUJ%U+C̿H8 .ay]v>v>?V١JWf~p]<^f]{a߿5SQ 1 XLҪ 5v6VTJjt|g 4}E,gmYZ]MXٺ6Ÿq;&ҩ&~"5 >YYHܥ Y} ) ғ]mHoi]^Ւ1/ 5͍3彧ph1k*7d;AYW!ڿ? !^@("6Xwx2MEWI6P=UfIV-k]^孧/(]~G`E7oiOY nX}{}uaSQ%З'zG=\G8Ar+z v ?:9<^#gΓ{=sc4ZGs3۷ʌ˩}VvDz5QZSxEqPƝGmh4~ֻ[]mm:ʛ;]89Ib܀UunKꞓ]VNʺ:^k:ti3EɻKkKUfV:S9Z'UU\ҩQU}SvBRGgekiVZGUlk 4ib5߭΅S.ߩꊭSiciMuRYtZzDSUzuʺB>%UIn7sU5U3Jj8}m6=p'Ѩ0l6:N|1U^"|WF2zɣQ~OɣQ*v_-(R'eҏ/ dMbV풣y7aYmsE?PYZ/nQܵ~z]_D< xhloޞ07"'6Re[a{EzN liW*9MxK__YnZ^0x*R-Q=`E X$4('BF@ޚ yhjzEauYXW ]4Kqy:MҚ)wJ+Y{u5o+;9W:/f3zH93x7H:=y{Vg"nu/)|7ksIK_poB0o:F5yO8{> sIK_KJ_ |10oB0o:F5yGg"nu/)|7ksIK_ xH|rx&y,QCFcPB hFcr41\V)y4UV檟(>b}7IMk2ϫVi:kWEVVQT51E)e]yɧDUQqFѸ8ql(9S1[w3'K%afm(qn}OLZQeEUU;KR}4ô/F3iNb/}*GCO1Y4Tl\8yFe4(Qv &5Y[[:G'U )7tMU65C+.ڴkllhuܛ7VD⪦Fc. _C+l4-'IN KT7gEU60EVu:+NpCMjiJ-l,4NuhVͪh-_p7(ETiMgi jJgfMʕ4i_ P`VaQou9uBzʭ-+XX颕\MQ--4nzNԽEQGS4aZ>֨W&58T% zoSzӧih2z;lZMoUU}+7KsQ+N W*)*sjꂪզ˲ J۴ZQM5UETZniT WeifuU*4IsGmzaeM4hO:VkE꧅&JUL$]{K+NXiPtWXhtJ׃n/Tr^chz=6'SVvgU6SMu5>c-?? H8n4gЮT1CH&} CywԱV||P_۹"SnOÏaH&} CiDϡ\a5N:Ϗw?J~~A)q E b\G8{ 2GFA P(crMx(2YvZTNnY]6y:'ekE(2#kGsv=HFzMV&鮪,g+:ZQU -v}NVdӡeaMUYoaUVRi$@Vtꆓm4;͓v.rՂѺ+:lU6(U NrȮ^Yv}Aaqu ޿vbōتEpc-=xxɣQzɣQ*v_-(R'eҏ/ dŰ5)1ORXtvB6(1 ,W'egiMW[V Hܣ7IfC5ʦ6WtN>+}73+ؤSD'y Pm];_L];_L>R{xxod$y{Z6t&.t&|G67}773|n˓{Z6t&.t&}V^^)r4`gEУ"M]O*^ꋛDN|&O 4XX˅,7 @NCR#TIPeBѴ5>?bѸvCR#TIPeCUS]ƬBSiy8Z|ly4_vee]PgcgiѿMٔfYݣp掎ݣpTpϜ{S6жeOcB۽'@GGYѸsGGYѸp8J8{^T4-Y~ <жeOcݣp掎ݣp08J8{^T4-Y~ <жeOc fymhѣ хF*4u63cGF>nyݪ"zcIX͝ [u:볩uXY8JI6tHֵb3ЃBQG۰"u2q2Ӛ3O E3L齧4'mUť&UT'2v,4h V<5¦Қ4(uGG'o*mo)GThRj~%z?wWzYVKwԔQQEUaRH(1NmM7iR*\hMQ]TMV{NG*2zYSM +AN]NmEvvUݢҚ)Vo q|4/TLmj]]k<'fMMVV:OTjVjUKШҫ0nj_Ef;F谶&~ҫ=I9h͝uJuT9rۗkhe>nKoTltkMҭjjT+R}U% c}AǢo]=PQEw<:MԫJ孍{TV'SM}hZ$hvu.Iy_zQKéLPKKvu[ԝMUOcׯ8*J^pvp.^&GU٪:]ZWZƊUVt*kWbkWC~QYZi}6|VaR--* B궴] ,8+/꺡^m⓿=z4{J):Hm,l*6M+5EUM]uaк.#IFh,Z[LlU_ dѴOi>WRFIvuSWWUgUՆ&-_\UUkIҮ*gga[MQR5KJ>|jI6gԪ mt ++U`It\讝#E}XFUnrvhr,[V5voS}Nߪ#Aө=4EvTge]4ߦ'~"5 >YYHݣ,>ȅWID.7Z|. rϗOƙi\z{! oZʽ) czUHk.|ˆW,|"+K/q|"?FIX)&bz~)4h|uxLfKo. Clh?]6>ө>}!^ޣ_#&pd)Vu>֬m+Z=IۥUF97@T--tj)Ѻ(UKo].#dT,ҭwENjyMPg.CLܳ)>{=OP`{QhF:_FZ;[oUxƎU^"׃[&QE[&QD<' |K@J>%;ji/r^|k($3UáQCP‹CE?'róWc]N[N*yv,{%miMXmRirk?bw.2:km>fyV[_3(yv?v?h1x; `?'qÝkm>f:ke/<ѻ] <ѻ] mkE?Rhdb(Qs]Ym|̣7x ?x  22ALt-&]}oSA? 5A; ](2 q(P̞5:mU֑}ݟiOWQ]IwZ5iUU9nR]ԍk^љgJ0Z1yX]]'F2 B(XJ(P>M3YbvuZ%.0)nX43xj՝5Uu:U2L&H߱i_e76ĶSIm3gȥ2:o() .)epaAGQعb6@XJUfI4Ob5tUJ}׺]Ö_ Oj{{ mX+T5SU$eV'X[,> VzYcc[YS1EJ.q0GLsHUvҥ( tZ+vZncgk]v|%6(J)SS{ 3FҕTzhLFD)TT] jZ9Zt* < N8ruS hk]>JɷEuZꥼ-[J:eWZVm+Ruq ÍPt -ҭ-k.AFΆ)]P`}]VVޭ.ںnGkUٙS~pHnn^qP E]\bʚ8Kk u'uK3W]ikLZ4Z쩥iKh%GUek]]6֔UWRBNX+:Ut_Uo583/t;5:MzEZ]]eB5:_i=KQM4ƫiH쩚4g @MUmRKET*vy=kYOUXUVjW*tpuWR =/H-m,++`UifV43 ^N{~ѨtjjX'o] U57qoPڋw;k46֧ZUfS)9<}zMU6ZTkceSzM2HKlM.FUګ{=OP`{QhF:_FZcm*\X}WF2-G-GUZQ N ^sll>I ZngoC4үxiݺYcW,n==e"Q`xIAMԉF8=%7ih^yoLΏuOҙo[|[}) vDv CbzFPب9Nv떯 3ٯ4,~~(j1 ߦ |+JATWZGV1_:mU֑}ݟiOWSvM؋?Qիm؋/Q״aMLU0 \ d^ GQA4,zR{KiXZ^RSӁ4˞UeEJtzUJDMPJbGie//mbGE!4 hQFd]2,來ya"]Ol5C:AF"YNqZG* GNkSԫuR QCXJx2|b6p |@TzEVz&UTt5+ T>4{zJ;jۯ쓊'M A*tHVuiInhZm4='Oz-`ݝnR)R[x]6UuVmjҪNڜdzmUU.W.muӇƠoi=H(֧Bʊ1Bћ^:{)2vt|}ga]i]v*Z:RC궋f:QKwuU-7yόڇ=ՒUKm&򖛇9IsK6jiM]PF^ϱNJ' xoCthvZiUS]6|"Y7JUT7i^ITjRj]Qy`̽:\;*lt\ҪQM-,}NiZQkFUnRu*4-qthZꖝMv*ʛUjEjj90 ~iU7-vT?ZV[FF͗/Uk.U.mVaa[EUml[ Z4~ZV+i\X6, lz([v=qUyԢP6]_ꝅ]4Z]U%zӷtg\4Auo4f֏v&sv^:{IYSKn; itk/*ښjSJ;Nh&ciiHҴwmcgM/֜\a{PSLVVMUЫSGkT-?:T馝.ޫZhmJͻKx^UiUVgEUY_ZW,U7UTSk Sz-6EWeRSCJRu%răP)5=ZSn[5giKi6UT̬N|֪ =RuNd z?Rj.~I>iTCtxmYE'55/8I,[eT;Otn.*Vn:8ҕz0%cۭԱm|3?Y19)g~Ҿ[. k۳׷f0 /WZivʺ:# nF,gD.7JO!u!UouxOVKŦ|Z|(64ϗO3czUHovֲJCYu#~BexZY,GL]1ywQR;]&W$1z 89*$xx7j cN[OխV]cCK=~RV&m}][y ]gUxt)mLY}"*]ڴЭt ymm6~եڴ qWc$|ak5.Q+5.Q{š{c#IG n/ջ׶Hj]f6ef6gφ#Ig n/ջ׶HHvv CbIA3  -BFf7!ghlT}PVdSV\{otoVe YSs'vDZ* q7i)Q]iX|ATWZGV1Wv}? ^ӷOYy؋?Q״f{o:gJ0Z2y%1RIE.eT1 9Zo=NF]KW4j*1i7 FwԭOд 5=YUJOҐ]MƋM*}sK"e6EmT(qefy>~WhVV4R覤T_Ql?Nǁɿ/],t?i]6Z:j-(΋KZkJim%=pU[ٻjl,mmlヴUlݥ4ݥ=R4kꍣfl벫VT+Zi~OT+Ugf{Z(VVTP(;ڣ?LBZUܯKMbmvЬj,l鲥&JXiת >ivqWKTW]N5*' bnSkXF*-Nʊ(ºqK lmh:T-鰲TUM UU=I$,=l»;k+[JtmvxKͤ o6G'YgY[3z»8L,O^GʈO^c={G9m/彯i1-{vc0uIx`zN é?/r?,Yn'?Ґߪ⊦4+EJ`CBQ ¡GCQF󮔲y'ᚶu/Szb>^->kzOStKjE4>euCP宔y'K'{^F7|%5]PDf!9k,IxbR8:ڹiw̮}"[3_yKkOd;AYW!+,IxgM.ёPC 6SF (4hBGS!Thd]Imm5kQ#HY|"1yKkV6tZU,暓iLpr6M E=V~K&vuav֊ӳ{L\5WgGkOxLG`6J8k^T kꙌh9*' k{S1%C0ȶI 466EJO(A:r,J/UFN׿3r5mey`zj.S?NSx޳(F8Sx޳(F8Z1ך=Y٢7@[0i\;{ WJeУ"A 0hT(BáQri!K(I)>LeYYS[yF~ǩTptS[+Cws?2=ÏlS*b,]LQ2=T"h4!PBr.'rA= c+hZ5zv~땷`/ ת][ESimkE+bTĖ,:>-YF\J-h_:x֛l:{n:]wtmjRne bwqާTMhvڪU6jl4[8n0#TvMu3Ht+K{=IVGR_o Υ@tQMn; ziҞ൩'zoRPAS3ZC鶮KK+:誺Uj)m=:m2HGll,nZ-lգE)…P:TЭUlml;:OmQڝKt[EHޞڵgaDTI&i8 vGt GZ2VfiUJV-USvk}%Izk-HѩUt:eRM8)4{EcmgiU7Sjo:3z~kCFګ^SkBT;'ާ(IΣYi:Ew--Ԣ|l2X٫kJ,TЫ+Kob:}m3z]={gWU]ťTBn5hܳ)7:UEuiTS?Y:v}>6z(OPd{TQxF!Qv&{,~4,~4&=~17 l.Gv} ^z>&m9/E-}g%hRus孟2 CF  946* 4*8A JAGlU u&lvbOUNSu.MN\M7Go_VeYR+vcFfVU/= }ԚkW5:W޲˃|Ơ6֏.zkGE=@|&ZÕMc8*8:jkhHִ}$YsϯRku 9^8XsX_1 "˞Ze_&ҐmU֑}5:DFFpС !Ggc6<\YE? ^ S6u"`QgLL9 [^ц_=|\UK㣱 hTBY8  rTZŧri<ؙL\غ4%ThB(8`c((J*O&fyEnK4foLд*jjWژT: uWUwl*tu%jKV軔VW+DQF :qaAȺ; X,"PDC( 8d8f7Եl:oN9[J5]Reꇸ(LɥVSUjKM*m(CS7]LiZFnֻ[N%n-%> X*Ь4+M Elg[Q[kn+K,ViTh}iM]mi`Vm%~jsosGӺmIҫJFbJn'Ǧ{GZ=2ڍ πݕTihuQD(n3l쩴tjl鱥ۺ*vQa۪7JM%ӥioiUoI,Jb;nsҚvech"Weciiv֧bک*Zν4= Ϋm.KJu]ƅޤURonS]z]n(Tں/\kQm[QhV*ZXSf곴D֪R&Q>Һuv6ZWmMNROL/F*骻EZI8F2aXciioggf}ETiCڪ]wuUT4UiQEvVv6665hQMWhU[jnMbfJ;Ge]MtYZas fިćvvz5Uo]Y:mGMP@<ڧJZ}UU[ƫ(85M4MڕKYTdڷIG¥_Wy5ˉFފ:6Qi:ip;4eRxa-ၫJ=54WiEiBR7_j'FVuvV-6W*΋Hƚ*9OYMYXޚm*UT *3/)5JGvn+eUTWJU$`xt4z,j(]vXz]XX_jm*BDʪ[W SJٍe {O֕];mΛk^Ev4PvN%9kHk4YtNdž(}e1֫vhziv]뇯yGƝ^3eKv5ScUjNQqD m2KeehjID&V=Rce]UUtZܯl PЪè P,--Ѭ]u*R,Ro$+4}*-El-[7ke'yZtKL5#gT4 },+z=ZީviuUIInҺSM~yV=m{G?F#g%=yrW{_2Ӓ4{v@k۳`zN Ǵg]kpVIxא7)Seg3vV{,$RP`BFS(ѣ4u2(*). Dn#(7iSV/z{:)ObU˦iUMJIWRP&gEÕyFiʼ?B" {QHvo?XF\\ךgEÕyGgEÕyMP~E#EA" ~^{XOz44Ϥ_*44Ϥ_*G`y0` @B 4(PCS#{SvґiTjigL$-K^hiIU6kU:,ڬ*7X"s Z^@z@t:GkOxLF]#嵧ʼ& z66GJO(A-R~Ez)ӕ_ eWK/U@i߫uxYX>ޮZ,˔xӔ7 .6Ѣ7 .6Ѣ6VuVf9xƚnD׷O9 #k`I(¡YD[Et|^UC6¾{ݴzebZhӁ-X k:ޥu*>ƥSQijO ֔Xث޵7*mX3СC<䂅 8H_Y3mwh +g=3IUt*޳ovRJOy[a +F֫;:(a;nh<\L-t5j^LW)TBr]_uZ%KJjҶDzTZ{QZHJ:JuSMŵTZ³ISJJzZ% BSaԝvuSKY*jK'bs0u'Dҭm[=ښIXlӋmNu8T,+ުjѬݝD+6 9d̽MvJjqOiCJQ $/mCIUVVfV\5QEU·L8I9--l4z&EI:j;]mJ3ڋZۭ*ޚi1%ꄣPꭅU5*R椡U BqC.}l*lkV5]Mˇ즪:itޅU烝։9Ouޗhʫ*i:K7g\t7(T(ʝ"E+չu*/ڃzEUUiSƻ')pvk$WŬYDYQVh]Z͒U¾źr5^ѺomiISe~+WkWhכl: ꣭40sZ& +VJvШUUvm:?ik]6"o+ :m(vm;%Z*Kr]*鶭:U֕M-t;hmF[+=vVV%]R(G":M?N(m**jͪ*J \n!ahvVw9FbS}<=0sFуF 8##Bv] ނq6{meE5YU)Z+բܛ:%uYiWbμ*T֪^w??hy.~x>o c,e<3\yO25=^w??, 5,e<1챖8+>d/=_Z??, 5,e(e83b់[&QDv6}<*gm{{ 鶜%oOv 'cҏ*Tl_Y=-vm9'Ek?xίݥ\EN? zo/_ 9Cc܅V+1V+1tnrT;u[]c疚P\[|.s׏^3@z2D5fQUe//4OVe YP=G y=^;ұzJ>ed'Hmk2 mz5{Rn9~?d5-{FJ$ZgKce1"bPP@262첹 AK>4(d )MmF Kf&cZ>EZUvݢSZ\Y6ڽKiWMiTUD֦%3WM>]bғKdrdq2C(xl8f7FPr 瑉Ȫ6)m41hCcي-ZM֧a+OEj!HzmYWe{J-%q_M/"OHҭtZUlUQX]SJ-eJK8FS9 ~[Zh&f/ z+kvLԔdX3ڲ۩ U\VΪ-,Tb6$X}EѴާ7JzK4Q+FNu'>Zno--m׃᪮;+]Rꊒlӽ]litA΍)Wc]/"*ikWUU5h({VOP NinQU:m84j]QU Qҩo]t5SL.j)]O0 K?j,:'a+; ,,,UJf}p޶ZMZ}V% iT2U87%:e-UᝥSTj RiѣU;SCCNU^tOtkGꆛ6ӔUEYJM:nZS,-=4;^[UͦR귵uQcaBҩszyej>vZEJҺ,4]BJzKpb[ʻoiXZXY; E ҋIږ詤ֹ ojkzt]<-cY֪iPnd*3'i^v&EvenݥV%vu^T̸\kꚶXSΫE]6uY\U;EU,S7*M쩢vtU.`Rii6En*kN5Ru8 eVwecaSgYգ:ZGoSO4,}zoUEV6ɪ뢉J]^^q)5&Lë5l(ZeeEv֪nƫHg}=KUMWSmMV٤R uj90IgK+-,ҪU5i5^4xQW۾ѡu*ubHе*ZNˇe{\i*l~ oaj֪N*iH-V鳹ieO *U6TSJR 9ѪcۭԱm|3?Y19)g~Ҿ[. k۳׷f0 /WZi~J:# nF,YD^e_n#(7i.lJ~4NUFr5@4jnߔR1h)ݿ)co@iW|fT>Y~XY]"U^ȃhz\>[Z}b2->U1z =x= }#%'W)?\ʯª X>ޮZ,,oW-^vbvpth]gPpvpth]gP\u+^Z|f:G3{[4Vf~ r& #kGs&Y$Vz9L9<\(4 DУ`…x_S-Oi mL#1nnZ-jT&[bҚRUBS״Yu6Λkj, k STYeH}(?C<03 QDPG3E7<Բ^ ѡ>;=MsӺmޮn қJ:U(n22}Svwk֛EMt]Jlx  uG>Rmm,K.NIih&MKJҍ2Z;9SS4z~QG;7kU6vTJvV)CO\dW.M\OFÂV4+%c^5RJ1x{J*ӤXuA4ji۫U4қq,)TlkZE,;*&Jp*VFSQE4*겡pt9[6`yGNiJmMt*릨]T(PY9h%uUg֚ESwhNqqتV&P4 *Hx>۸}QybꎒkQQeEJ*,*E4%ڤtjiVUgJʫJ쩢sMUUJM1kOM4z,ۥR8b}cM:EUZiTߢ*h6ҿN[kM [kv쩴VUQzdԺ} . KZƊ(9NQQmhjNivV5SbJSħ^z}:+ѓT+*xWbw`iO!nY{gcz#&N{me+Ċ7Oab <W6P[&QE[&QDiG'cҏ*Tl_Y=-rm9'Ek?xu7xy~ * < !mGpmGpܼ#o/v 𲜸{]@}XͳچCRc6C tSj]osǴii'|?MY5fK~__h|a/gڂKzV1#M<)Ml+K~iiVwo:uQMpjp4|{}Lçچ 8v7G|uC*o O{CF4(£BE -iUcK4{%0#W4pzv6]M("-yݮo;mȑӴm;ln.R颚Ugi+Kb(5h]]UiT<je:ʋ7UZ^iUuJ|Dxu G /L;%+~UR0cORXSmM.~WM<sXSkoMm:E5%.r^M&'WEo]vS[huԕvvUnWRXOg=[Z뢍֪T֕y'LϨzѬ [ tEE5;*|qJŴ ?j}hh}OѬ]vU]u6Ovv%6nқWZ*]vt®O ЛZ*4}GNiUMNTcd`PEze:5oT;V ŴMQk;zӲEXxfÆnXZp64.Κ٦4ҝ+,Y#OZ/^=h'waNvN#Q,imli*ꡥ5e =N{jt}֝FVU:F9:n{Xhvֺ֖5uԭsdl S29~KFVNESg49Ko}Bꝝ^jStQqT&- ե.ٻ,xj%[ttÌ.ҫZ괭Uokn[7PVV[WoM*gqʥS]CꝽkUJUioQXWYhֵ޽Z¹sk<}I֋׏FZ4'waNvN ҪcۭԱi2gʈO^c={G9m+彯i1-{vc0uIx`zN é?/r?,YnSݤGQHoGm"?2JC~,_ e͟iOWiʼ6NUF@MJF3#ڛ>m-*O:~`}ػ?+ :ec. =Vz:j{Uȍ#嵧ʼ&#.e^ǯ==R~Ez, GJO(A:r,ie +:j.S?NSx޳(F8Sx޳(F8Z1ך=Y٢7g?T5͍!s'LsH-:EJãF6D8:3X<Rz0ct(Qm uG?J8݊aQYػjTKUFCvDvt~&p>RGMT-JΫZ]m-{m++։CwyT!)$:(0lTraBc_MmC#:> {WT-zՊ*i\JҚeJNשv[K: MRZ=\\Ž5CuMqtPx+Zt{#E; m)t_RU$e8zzj]**KZh)P迟m q /j]*ƛhJBѬlEvsˈ*hYUrZ_[iYcVYJhevѤhEvvմO4j&ZCѪU,T<=/EѫY7MWfP;s%k#]V:EVX քꪚ(oNM?B4ѭ/R*oWL\Ui"hoSHUE ]CI(Wi6v;TWUuEU]UwuUTj#{LYX+;}J 4eMU42Nu'V4YYXkVUnE2Diu_VXv*ҊltQy5WUU9eQX{JW^ZפYUiWggeEjkkiڟcW]ZXZ]#v6-RqhZZYZ+k-,6tZjn*Q:ߨWiigkg*WcSU,Rs >ҞCLܳj<{=޶z lo[Dz=g| oE>0w]^jB4z/^B4z @J>O;|. Q[fIol_Y=-W~[Y#uM*^k3DOfPo= lW\b= lW\b=ݦ9v{]彻]wm2QP9xxՌ?|/IMlT:&}zN[BD2c-h-,4R&aQ_ iML^q0GՙCVocy1>6>LμHⲘRc-P-{ʹq枅{?TP\i|>OyWe1_ZyW3S5_Z|VSjp\y{">`}%蟅 v4{5Ԭmҕk]S[VҊŜզ\,m({KT|&V9=AҩV5XZZ7gRKgT*l+v>oFMvVt_Vz=8:o$m#j[peUogi]Ex%EiS]15NUj)vvjΧZ\tĘ*8iiMw6=M+i>*}!VTiHŧThUF^g:8;RU|.KIRHӪcۭԱm}K$TS dD:4hP 2 4h<]$B\4kchZEy5,,;SU蔞FJ:i4[*)tU0ݥ<*kT=O_0z:~H~ %7 `Y\p m:zcb{`Ct=eTK4+ni ML(JXTaE0qhBGB.7!F ,6Mԫz$ށegE3u4akT=O_[趺6vvԪj*SKh7hcg,ѻḤҐߋYMc"eҨ0aP*PчF7S!kl Ҏ&W:i`֋K+GEV"ͧ*#T(8zv-lii7JɻE<Ʒ{T|7t6oGGvzO*f6= SpziGʯQx7J8^fnq3vz8^fjoнm?G{U{SvґUzQqcFх SF tv3S#7|eևe]RwjzE.ZW&jogF{vid۪ggU/Yؽ~O/fZ2\>[Z}b2->Wx lQ^ C6*:> _8f64(1btW!IUx,o_-^Wt*jjv^).\aN="+Ε]ooMmNպ(5+ҧSjZҭ>}գGZ^ SJSԀO mh3t2i]qBv-bwk4m{wSUUSVNMR*Uf8#O_HGʛJ,kET:h¨UvS=kf+k6d +okkzZljv+]&VitUTS[NU:>E:=4XiUNW*nt&TSVTغލKnKtqLuR{+b֚ꦪ-({էv ڻ*Yz5+J]JM̅]i+IѣU U-=bnnSm#UUU6;7eKRioS]غVOq0smhԻ7gNEtֵZu^u:S/ Ց*aiaMJދ&i[[Ii:&E.FՅWgUs9Tji8{WlmvUvj֪,[U5BaJ nYfiO!wv7=l;A6Y,¼H~Z/y.ذϱux plLѢ )43EѡB*8IGQE(3:mkC [[*aT'OiV4T+ڄ/_& Tu*e>ʬd֏.z?T~=GP6mkC ;K~}{{TjkhHִ}$Y~Ol>ֆDZhJc/:F-Ze?hHJl>҆=Fc<;K~ѽGF6֏/Ez" -]qXu8Trr ?p= 1ΞwMoxYN\[?Zj)GY ga:)= +ga:)= ATniyY'_z7Fh|toz'2+7MC7p ~xݳr>zV1f Kt2(aBBF2,9:X-^g]p륩2+UbգRi!n._%fmԝ2JkjӍkRhκEG^8* RU13Np@WMvPljkgRU5Si8iD,2ҴgJ貵&vtWjPƕ-a]{ҟ7Rt:mU6j+URԼuޜ'J"Ѵi(U]nn%1Y:CiKZm$1ӢWVVzM66r0\ØvsM8Ԫcۭ5,{uf>[?V[)Z]|+jvیF[nqd>yuDgf]oC 6/rWOe2?,lYneJBs:iRξJ=) yX"|O(6_%?PP{Sl_S*c5ʽ+e⣫.}^ 7X"}ػ?01{7^EC=AZڮDh->We>[Z|. zw2/|E7q;c"@Z w\/W{[?,o_-^W >@ %x;faH^m+z dvꐽMh(7rG#)YS{Y75͍#kE+ l42lpyGY?FIOd[F:z7Pݨc.:GbV}T:jnMl2SQ^J seMҴFGvjN Ԟ~SG~(zfz2T[TTyg5t_*1d9ϕ_j Y{uX)=zes?U+Gu*iUhtke_U,4Ѭʼ-& QOk>n[:ouұSg}hѸ} Jze]|^ X;:[&9z=(HZVN֥UMYQBRI#ZڎߨzgԻ+JKiBN^kKN-PcnuCKVnFVUiٵMMq&`fסGVVFkkZ']VܼJ*7ihZvkkEjm#CջTۭ˭8BPecTz- kUtM.>/5 TɣQzɣQ~ZQ|$ tJlOU<[/=d~TM7$^O>&i/|L=<{Ccԅ R;x DO.q=p, umK{__ZxYP[Z*T=@}HݳĬF힇>6&M9Qg!{^j̯7FbOVe}YVnŸ7l܏ޕ}nGoJ>ڎ׷O[%x /奟=MK^ћz_K?{tiE̞{"A *(uDdQ `QFB jTHVUx)3wGu,K44zeVT[lW-T.ҕ-qft>kCahN4:4~h4toSNZecskQՎmkmMO;Kڽ|}RuR½+Z=FiogeeL+;:JҮ еaoWt^Yz_^UvJT;+6 ov}Yд^פ[QTSѩwnrꉻ ֱRkx;z4eViwpSj +n3N3uƬOiWmV4KtQc릛jnm)TҌ]Lƌx]6ʽ7]yy誻 :qZyvJk>p>Ծu*ʻ])i6v4ZEv:ij*x9=I&Në=N=6u]Z-V^i)͒MWY`|ժt=CkiV^g RUSE]M V ΢ǫFvyhUhتڨ\5bp{:iljhRtU:.k`Ҫ&2h֪ҺuUSm-f.dTW66UD,(P`بdBl#iU+$G 8Qhѡ~5Ld(+N WUU^sg*( ,5UQe]TT66HYi>yl-4ƫGUU*h庞I-vjV:9nb25loVVoՒLd()Y)4Mr£ |ļ]c-' ='6!;;m2]w(uUvSNm"v:Nv֊)mM<$қÌU9Uj* Ri+%&ɮQxS~ =eUeU2[W8ZlJtu)S3XSHHHJUnuK,̅[#[gB l4!P2NI2k^'Id("b £ 4v,n2 &[Xz/s5zI l;:鮗EP4mګ{;^ҫʚ Үu:&tk)g_%SҊUd9(P… T 4hѣFI2{^NϫM<wiJolQ)%݇]VDŽi4U5J "-*[M|ЫvI;ad)d()Yie(Ѧx/L9k8@ڷF^kaoiZM JM]QJs(Nj J {*RT*mҚ}@:ah%&;LɺPKne#.՛-HѺhݝGRTt^4grϴ^tҭj]5MڛZpӇlRJT+=E33UYFg;A6W,Sy) *PAGFQѰhhdqrOHE҆i4irj=V&'ablt[ P]*j;,D&"ʥ7JSHeR +?_޳YWM'e_ȏ5t_ Y"NHer !HM҆;:ʽ uV7iU)ݍ=WHeş$-G,St(R;Qt:j1,~ZQ|#]#eȞ S?N~螫#xG"cT$0ƒ] `ѡc4(QrNZ8$ӳT:ٗHէL`/|L2rzRD#&qI>3Yqsl^Jؽ)ԬQ3 EbG8jxYqsWUT+-2BVOAL?8XgAĎ޳" Jؽ(z넟`8_~".*U mEF (PѡZyMhWTf}#G5Z*ʃeiu֤n.n`שKUm֩SFH6ЯS:miۭR<+j4m_8jv1Vi~CLw܎{;nQg$:[->#ڭR<+j4m_8jv1Vi~CLuecꭿDVOэ=|/IIlK$),T)%FT(1Y 9Fwf{HYe6xz6E=F{{  Gb,}}?MYfYZuV%M.iIJ*iXfoIo?)<=#IeF$m&_Yq:Ӌ ]p}(P-SoGԒ)ĎgieVMʓ_M׌]y59\>_OHYe6x}I,xH.>av\PbG})ٞ7l܏ޕ}--E QF*+Gh0У QB7B Iԭުm~vSԑa|'7Ik3ikRnSM*RKc֪7d/?Ik2R)==FC1aGGF9:4џGV6vJg1'ˮ.&閚'鵥SU6*I=E3gRieYBe4hP 4wz9$)tZiWҬ+1q43Tݳp>t-W>$-K{'cr·]5>Pۥ4d)ߩNwPӴE]ʪ⪓rxxK7d릍Vnkx':-thҪJӅ| [)1E9RuOLkj,^*T^TseWR4m+6VvniTYMZS8Xbmogi]tgSZtKɦd-MTUJJIړxv7kDέҫD6)T*/Ka3iPӨG莪(bVӛևSMMTtڙ6Q]zU]rkW}.;HHTԭ*SeRtD,-+6kakggVSj yU+O`Jq5]; zVu*TۊlNLJj~QVvh[ZSa[u*y_R'FkKjNʖpR%9wHꮟVUr֪,kH^ֻZ;&^}:=^hZ5EMZY*Z,mVDUV):+ޢK8p>tVVnq627vv:FF+gcav*ZWi M*xĊKPtX~+ꆙENkM5qZT5ԩt^wM8J@2+VwiZå*n%TMNGoWT-}PNvuWMtZY5J)XRQR'm[eEniBK53#ꆘ곩C*izshʋJl[gEvuYhUUUݫU;RrR}*Uv% Til& i"D-ZX:Ut*lGiXh-k- V5Zhɧ] &$rӓjSX8惩m˜S9v6:=:7T*] ivvTZv]7be7ԋ tMZ]UTO]+Ø[KLܗvvB5ET'Yo]z-뢋J +U3ֻ-"ښ袭Se_dMj-$:1|"ҫl_i]izj))DPKKn{R}=G~>{Vꩺ5;DI}e Z[4+'SmH}v=F-WS6:EN%toiTezOymiR]MQڦ.M\SVhkh])ZIU:Jlv^Vڛou}E};=tR}1SajU6Nhç6k-h;+zmXT)i뺳]}!UXY륪l變,)VNUVs(zziX-J6鶮Rb1i:T8em] i :ҲKIS*u,Lзҭ4; :f;}Lꆋc{giC.Zõ:D39RWVnW`Mp2խ*em7֫GOaUT|.KҴZ)ƛRT$j#ii֖>-5tYX7YX;+JjݚNUMm=j{UUdkM)ZUBX*]RѵgO4XhU٫ JVzfS/,2*t'o%Xr 0X:Ρh>ԭ+Eiiv6v6nҪ1S93b.ڋTYjmpXߡ:SO<`UQekZŭbnBGeUͥ^̙Q{J;SgFij,覇c:{*TK%=ѥoK=&굵]iNM*{0K:GUebuߪ‹;JǶ[T BTNuP[r۽m4:oh]VKtEڕjt>}-zu]Vz,覛8;7)5Ꝧ6Bv:UVnCQgVe^ʻk; "M‹;"M:*ILTSKq]vVEv4ܲҷE;)mVZM%kMTWEh+*nЩdJkKGk]UuTR4Ԓ. wR,t΢WVtNtS;+O+G"lS[QcM5E[;ZabJg<z'"JZYN'>stream endstream endobj 1314 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 70.936 724.8299 Tm [(\037\036)10(\032\223\212\226\034\022\031\034)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0 Tc 0.064 Tw 10 0 0 10 70.8661 700.4739 Tm (\025\035\017\027\017\004\036\f\022\026\016 \f\017\n\023\021\024\n\026\021\ \017\022\026 \212\207 \030\026\r\017\r\026\036\021\f\016 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\r\024\f)Tj 0 Tw (-)Tj 0.052 Tw 0 -1.218 TD [(\023\026\035\036\027\017\017 )0.6(\f\021\036\027\022\017 )0.5(\007\017\r\036\030\021\017\022\031\035\026 )0.6(\r)]TJ /Span<>> BDC ( )Tj EMC [(\030\036\031\035\034\021\026\021\036 )0.6(\035\024\022\026\035\034\027\024\005 )]TJ 0.313 Tw T* (\017\001\036\n\017\017 \f\035\017\017\f\021\024\005 \007\017\r\036\030\021\ \017\022\031\035\026 \023\024)Tj /Span<>> BDC ( )Tj EMC (\023\030\017\004\017\027\036 \f\007\026\r)Tj 0 Tw (-)Tj 0.265 Tw T* (\035\036\027\017\016 \f\024\f\031\007\024\r \023\024\007\f\035\017\017\f\ \021\024\020\024 \f\035\024\016, \021\030\026\r\n\t \f\021\036\027\024\022\ )Tj 0.122 Tw T* (\007\017\r\036\030\021\017\022\031\035\026 \023\035\024\021\027\t\n\017 \ \022\026\035\024\r\t\n\017 \022\026\n\027\016\n\017 \017)Tj /Span<>> BDC ( )Tj EMC (\n\017\022\030\024)Tj 0 Tw (-)Tj 0.309 Tw 0 -1.218 TD (\023\036\030\235\024\030\026\006\017\005 [10]. \222\n\036\027\036\027\027\ \026\016 \n\017\022\030\024\235\035\024\030\026 \n\024\032\036\021 )Tj 0.311 Tw 0 -1.218 TD (\f\023\024\f\024\002\f\021\r\024\r\026\021\034 \n\017\022\030\024\023\036\ \030\235\024\030\026\006\017\017 \017)Tj /Span<>> BDC ( )Tj EMC (\r\016\035\024\021\036\022\031\013\036\n\031 )Tj 0.356 Tw T* (\r\024\f\023\026\035\036\027\017\033, \027\026\030\031\001\026\016 \002\026\ \030\034\036\030\027\031\033 \235\031\027\022\006\017\033 \f\035\017\017\ )Tj 0 Tw (-)Tj 0.11 Tw T* (\f\021\024\005 \024\002\024\035\024\004\022\017 \017)Tj /Span<>> BDC ( )Tj EMC (\f\021\017\n\031\035\017\030\031\016 \r\t\f\r\024\002\024\032\007\036\027\ \017\036 \r\024\f\023\026)Tj 0 Tw (-)Tj 0.064 Tw T* (\035\017\021\036\035\034\027\t\b \006\017\021\024\022\017\027\024\r [11]\ . \200)Tj /Span<>> BDC ( )Tj EMC (\023\024\035\034\031 \220\021\017\024\035\024\020\017\004\036\f\022\024\ \005 )Tj 0.308 Tw 0 -1.218 TD (\027\026\004\017\n\024\f\021\017 \022\017\001\036\004\027\024\005 \n\017\ \022\030\024\002\017\024\021\t \r)Tj /Span<>> BDC ( )Tj EMC (\030\026\r\017\021\017\017 \212\207 )Tj 0.267 Tw 0 -1.218 TD (\f\r\017\007\036\021\036\035\034\f\021\r\031\033\021 \017\n\036\027\036\ \027\017\016 \r)Tj /Span<>> BDC ( )Tj EMC (\f\024\f\021\026\r\036 \n\017\022\030\024\002\017\024\021\t )Tj 0.034 Tw 0 -1.218 TD (\031)Tj /Span<>> BDC ( )Tj EMC [(\023\026\006\017\036\027\021\024\r )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC 6.004 0 Td [(\212\207 [5], )0.5(\026)]TJ /Span<>> BDC ( )Tj EMC [(\021\026\022\032\036 )0.5(\220\235\235\036\022\021\017\r\027\024\f\021\034 )0.5(\030\017\235\026\022)]TJ 0 Tw (-)Tj 0.223 Tw -6.004 -1.218 Td (\f\017\n\017\027\026 \017)Tj /Span<>> BDC ( )Tj EMC (\027\036\022\024\021\024\030\t\b \023\030\024\002\017\024\021\017\022\024\ \r \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\035\036\004\036\027\017\017 \212\207 )Tj 0.318 Tw 0 -1.218 TD [([7,8]. \216\026\030\026\022\021\036\030\017\f\021\017\022\026 )0.5(\n\017\022\030\024\002\017\024\021\t \023\024\035\024\f\021\017 \007\017\ \r\036\030)]TJ 0 Tw (-)Tj 0.111 Tw 0 -1.218 TD (\021\017\022\031\035\024\r \r)Tj /Span<>> BDC ( )Tj EMC (\030\036\036\006\017\030\024\r\026\027\027\t\b \023\030\036\023\026\030\ \026\021\026\b \f\017\020\n\024\r\017\007\027\024\005 )Tj 0.261 Tw 0 -1.218 TD (\022\017\001\022\017 \023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\r\024\f\023\026\035\017\021\036\035\034\027\t\n\017 \024\f\035\024\032\027\ \036\027\017\016)Tj 0 Tw (-)Tj 0.119 Tw 0 -1.218 TD [(\n\017 )0.5(\212\207 )0.5(\023\024\r\024\035\017\021 )0.5(\024\023\030\036\007\036\035\017\021\034 )0.6(\f\023\036\006\017\235\017\022\031 )0.5(\n\017\022\030\024\002\017\024\021\t )]TJ 0.037 Tw 23.244 23.138 Td (\r)Tj /Span<>> BDC ( )Tj EMC (\026\n\022\027\031\021\024\n \023\030\024\f\021\030\026\027\f\021\r\036\ \007\017\r\036\030\021\017\022\031\035\026 \017)Tj /Span<>> BDC ( )Tj EMC (\036\036 \r\024\n\024\032)Tj 0 Tw (-)Tj 0.084 Tw T* (\027\031\033 \021\030\017\020\020\036\030\027\031\033 \030\024\035\034 \r\ )Tj /Span<>> BDC ( )Tj EMC (\023\026\021\024\020\036\027\036\036 \024\f\021\030\024\020\024 \007\017\ \r\036\030\021\017)Tj 0 Tw (-)Tj T* (\022\031\035\017\021\026 \(\210\212\).)Tj 0.646 Tw T* (\210\f\027\024\r\031 \022\017\001\036\004\027\024\005 \n\017\022\030\024\ \002\017\024\021\t \031)Tj /Span<>> BDC ( )Tj EMC (\004\036\035\024\r\036\022\026 \022\026\022 )Tj 0.513 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\027\024\030\n\036, \021\026\022 \017)Tj /Span<>> BDC ( )Tj EMC [(\023\030\017 \030\026\035\017\004\027\t\b \023\026\021\024\035\024\020\017\ \016\b )0.5(\f\024)]TJ 0 Tw (-)Tj 0.299 Tw T* (\f\021\026\r\035\016\033\021 \235\017\035\t )Tj /T1_2 1 Tf 0 Tw [(Fir)-14(micutes)]TJ /T1_1 1 Tf 0.299 Tw ( \017)Tj /Span<>> BDC ( )Tj EMC /T1_2 1 Tf 0 Tw (Bacteroidetes, )Tj /T1_1 1 Tf 0.299 Tw 18.798 0 Td (\026)Tj /Span<>> BDC ( )Tj EMC (\023\030\036\007)Tj 0 Tw (-)Tj 0.79 Tw -18.798 -1.218 Td [(\f\021\026\r\035\036\027\027\024\f\021\034 )0.5(\235\017\035 )]TJ /T1_2 1 Tf 9.179 0 Td [(Pro)13(teobacter)-37(ia, )0.5(Actinobacter)-36.9(ia, )]TJ 0.018 Tw -9.179 -1.218 Td [(F)24(usobacter)-36.9(ia, V)33(er)-16(rucomicrobia)]TJ /T1_1 1 Tf ( \017)Tj /Span<>> BDC ( )Tj EMC (\007\030. \024\002\t\004\027\024 \027\017\032\036 [12]. )Tj 0.146 Tw T* [(\212\036\005\f\021\r\017\021\036\035\034\027\024, )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC [(\017\f\f\035\036\007\031\036\n\t\b )0.5(\024\002\030\026\006\026\b \023\030\036\007\f\021\026\r\017)]TJ 0 Tw (-)Tj T* (\021\036\035\017 )Tj /T1_2 1 Tf 2.187 0 Td [(Fir)-14(micutes)]TJ /T1_1 1 Tf 0.114 Tw ( \017)Tj /Span<>> BDC ( )Tj EMC /T1_2 1 Tf 0 Tw (Bacteroidetes )Tj /T1_1 1 Tf 0.114 Tw 10.945 0 Td (\f\031\n\n\026\030\027\024 \f\024\f\021\026\r\035\016\035\017 )Tj 0.148 Tw -13.132 -1.218 Td (\024\021 62,2% \(\2253\) \007\024)Tj /Span<>> BDC ( )Tj EMC (85,9% \(\2251\) \024\021 \r\f\036\005 \n\017\022\030\024\002\017\024\021\ \t. )Tj 0.49 Tw T* (\222\f\f\035\036\007\024\r\026\r \024\021\027\024\001\036\027\017\036 )Tj /T1_2 1 Tf 0 Tw [(Fir)-13.9(micutes )]TJ /T1_1 1 Tf 15.607 0 Td (\022)Tj /Span<>> BDC ( )Tj EMC /T1_2 1 Tf 1.184 0 Td (Bacteroidetes )Tj /T1_1 1 Tf 0.177 Tw -16.791 -1.218 Td (\(F/B\), \022\024\021\024\030\024\036)Tj /T1_2 1 Tf 0 Tw ( )Tj /T1_1 1 Tf 0.177 Tw 6.469 0 Td (\001\017\030\024\022\024 \017\f\023\024\035\034\031\036\021\f\016 \r)Tj /Span<>> BDC ( )Tj EMC (\022\026\004\036\f\021\r\036 \b\026)Tj 0 Tw (-)Tj 0.058 Tw -6.469 -1.218 Td (\030\026\022\021\036\030\017\f\021\017\022\017 \f\024\f\021\024\016\027\017\ \016 \022\017\001\036\004\027\024\005 \n\017\022\030\024\002\017\024\021\ \t [13], )Tj 0.099 Tw 0 -1.218 TD (\n\t \024\002\027\026\030\031\032\017\035\017, \004\021\024 \r)Tj /Span<>> BDC ( )Tj EMC (\021\030\036\b \024\002\030\026\006\026\b )Tj /T1_2 1 Tf 0 Tw [(Fir)-14(micutes)]TJ /T1_1 1 Tf 0.099 Tw ( \023\030\036)Tj 0 Tw (-)Tj 0.234 Tw 0 -1.218 TD (\024\002\035\026\007\026\035\017 \027\026\007 )Tj /T1_2 1 Tf 0 Tw (Bacteroidetes,)Tj /T1_1 1 Tf 0.234 Tw ( \026)Tj /Span<>> BDC ( )Tj EMC (\r \024\002\030\026\006\036 \2254 \022\024\035\017)Tj 0 Tw (-)Tj 0.185 Tw 0 -1.218 TD [(\004\036\f\021\r\024 \220\021\017\b )0.5(\007\r\031\b )0.5(\235\017\035 \002\t\035\024 \023\030\017\n\036\030\027\024 )0.5(\024\007\017\027\026\022\024\r\t\n. )]TJ 0.255 Tw 0 -1.218 TD (\200\t\f\024\022\017\036 \027\026\004\036\027\017\016 F/B \r\f\021\030\036\ \004\026\033\021\f\016 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\024\032\017\030\036\027\017\017 )Tj 0.084 Tw 0 -1.218 TD [([14], \f\026\b\026\030\027\024\n )0.5(\007\017\026\002\036\021\036 )0.5([15] \017)]TJ /Span<>> BDC ( )Tj EMC [(\f\017\027\007\030\024\n\036 )0.5(\030\026\007\030\026\032\036\027)]TJ 0 Tw (-)Tj 0.307 Tw 0 -1.218 TD (\027\024\020\024 \022\017\001\036\004\027\017\022\026 [16]. \210\002\030\ \026\036\006 \2253 \002\t\035 \027\036\024\002\t\004\036\027 )Tj ET q 70.866 133.396 311.811 344.806 re W n q /GS0 gs 311.8109423 0 0 344.8068512 70.8661365 133.3959311 cm /Im0 Do Q Q BT 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0.077 Tw 9 0 0 9 70.8661 122.5959 Tm (\022\t\217\210\b\002\220 1.)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf ( \213\031\024\026-\032\026\016\021\n\n\005\032\026\016\025\031 \003\025\013\ \032\n\005\025\n\024\020 \027\n\t\033\026\023\031\021\021\020\004 \030\025\ \027\031\032\024\025\013\205\023\n\027. \201)Tj /Span<>> BDC ( )Tj EMC (\227 \220\031\033\023\n\027\026\002 \013\026\032\024\026, \033\n\t\024\032\ \n\031\021\021\026\002 \021\026)Tj /Span<>> BDC ( )Tj EMC (\n\t\021\n\027\031 )Tj 0 Tw 0 -1.2 TD (\013\032\025\024\031\032\025\002 \021\031\t\004\n\030\t\024\027\026 \213\ \032\031\002-\222\245\032\024\025\t\026. \213)Tj /Span<>> BDC ( )Tj EMC (\227 \200\027\n\017\021\026\002 \030\025\026\202\032\026\003\003\026 PCA\ .)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf -0.025 Tw T* [(F)-16(igure 1)47(.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf [( Beta-div)13(ersity of in\234amed div)13(er)-40(ticula. A)]TJ /Span<>> BDC ( )Tj EMC [(\227 Heatmap shows deg)14(ree of dissimilar)-37(ity based on Bray)-14(-Cur)-40(tis inde)-15(x. \213)]TJ /Span<>> BDC ( )Tj EMC [(\227 Pr)-37(in)]TJ 0 Tw (-)Tj 0.023 Tw T* [(cipal-coordinate analysis \(PC)-18(A\) biplo)13(t. Ar)-16(rows rep)46(resent individual families dr)-37(iving the separation of sam)16(ples along the p)46(r)-36.9(incipal )]TJ 0 Tw T* [(com)16(ponents, and their length cor)-15.7(relates with the feature loadings and the biplo)13(t axis. Colored do)13(ts rep)46(resent dif)-40(ferent sam)16(ples)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\033\030\031\030\213\b)-20.9(\035\231\213\233\t \021\032)50(\b)42(\032\231\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj -51.938 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 23, \023\0221)69(, 202)69(4)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 23, \023\0221)69(, 202)69(4)]TJ /T1_5 1 Tf 25 0 0 25 19.9277 56.0378 Tm (112)Tj ET endstream endobj 1315 0 obj <>stream Adobed     '$''''$25552;;;;;;;;;;   %%#(((((#,0000,7;;;7;;;;;;;;;;   %%#(((((#,0000,7;;;7;;;;;;;;;;   %%#(((((#,0000,7;;;7;;;;;;;;;;)""  }!1Q"ARSTUaq3Bb #$%&'()*2456789:CDEFGHIJVWXYZcdefghijrstuvwxyz }!1AQaRbq"BSc #$%&'()*23456789:CDEFGHIJTUVWXYZdefghijrstuvwxyz?`:W'MvUq7mk[8m/qq짹M5D(YGgG#_]Or9"{粞1L3zΎF:=3:9g&tSܸt2"{2^g-L3Ge=˅ZO"'V֎{c'T\pwdx#eN6sh7g]i>O+hmhQMmz8hi]ks3<#+U1TŦi5[v-.Z]auWu< ںQ]ZQNRmMQyEZ~k:Ncע'6S3*yxWʶCY_WY_*ee~_ 9WPRW ~upҧ:j~oү~oQJ` \~5Q(Vkz=޽KT*~>^ϳzҤnk'{7x^ޓ`կz8%Wҽ[[=;S#5z毞{dw\Vz/P))TvX]p?*;U(Wog+eE[{9_k* Ѫ`@ӑ) /^W\rj+ryd̪b36δYqiOety~GS[s6nka x\nx/{S#lw=5O'*fꘉ;V.|ܸtMc{srιWDM1bk;sJ?,+xe)xmꉘ1LQrʙޣ}q1< D랇Iy O}rO8'?,īGfOSܿV|ZGT<][_Y<13Sh:;ƞ hKx/M̪#/4LfݺgBסYנXpfR5S=77տ&C='|4p_#Kxw6='񹱭7W7wwz#:ޞڷdjiUE8a9|icذd36D*evZ8}th͵7轡=bzu=W LNNܳ:azzik~:K3pf̟Čn ٓ%vj{lsǯ{`*N3qbgl7 Dk~:Lu2_2?]p?XL%ό{FO-M1]4U*͙;@3MrZc*/UVNfM5E'v@Ҫ`2C"Cr@<w\YvefW+©εa(b&yU{NN[qw)ٻ_#;pޗ{N8 8]|KЃ=ty']vn9r3V[)^FfMTҷgs1諬 Edx:|'2fUwJ#";;=sj;˾̷Qbc)7ͪŦ5W:VB#!NvN8>.r|Shͧ'M)ζf8ͺ!C6,2d7d=m['xͫd<0WY2wwnzuѓ;%jjLhXղwEDG1wwxvn6fղwEDC]qÔr^p)ZbZ::cjW^z3{g5J[D8n9N=fղwڶNȷ~~=a}V&ʝZ$$%[VΣ3+TXMS:y1<sӉfDU1"&3zk+#iͦ,cڷS77HQ4muk4LuvaN5˖Wvn܈ritv;"׊+̚׍ShE .i|Z+H޵7cUމDLuCv8ŚȷvwZ(^W]LV{Z4jzab[X~E"`{HѹV*DZ]TLUok6oΧ卋v,bۛ&&jת":}zZ9_n~*k)mz%hXs]I]"MSnNf)މR8fzfфSU̎;=e96jMUSM65oƮ~'MTWUƪc10ؙ#IZgsȪqiz5uZuLƸfXkU暪s3MQWS17:5o=w;]t89m^tO1SBE]b(g _ܾG'E3^O+՟m3i8*pZCGDTETє_KE>T䨦h:)9h͛F'-uy:2VS%NR"STͯ1xW_8uyzrTQlהdS4VQV|t\p4SO j2S}sL71f:QS֜erzkY>?%̬DW71TFժ`.N2"@ oyCϰ*>qRK{O}Q;XV-/>| &<ǀ{Ea{yɲV }hxȳ4uϻ)3S32\BP&ŝtN:}gSYy=_wjwqFKJس'>㭇}iOupi"4ӁMmʺ7ifsYYhpE3c:qth嫧-NmUx& ؠq83N5y-nel#р.]?5yƢ=8}t&=@Q_Zqgj+N9ӎWHl#р.]?{/=s>\j+N9ץ6VƬёV\d{XV#ԘKrәFRU3jr 6݀{XɵL^s&Mrd92mc%pxȳ?MreN>=ڦppuf=1Ś:yh,SGp *rPqJD|,SGpqfZ;:^Ő}\o;4uY΃Wd/xW%\w߮|,SGp,i&ܧ~=뉪-<,䠞"g:0,<&3@ת`lMV[.i/aU`Oo2h%lVFe)U~Q{b%=~~H/z>~mȿ]ӮQTWmi, w2-7(1軻F7(FȎJx"3bڦf-x{Kfc1xpINb-],6()uDmHy,ef"biκ*6@[gazVFeoʯ ':@ &ؽo&[1)LWLSUv⽶~vW< D]<3'ef-9ٵZշLnV$'2$'2+9>l^PÀc``o5Vf=]QFiNks_k#/&"XnW"3Uɘ'TF)T>h>\m>:; sn՛,ڝ~E7#]qV\QFR+Ѳ':jiӶz~H/z>~~H/z>~ ˳gh-gJhU4+ntf5Mڭ4\b#\]{ci kZro[^hc4_EI4+jrIU4L14k\Q73;Yc(?xJ-zGZ'&̔&̖ Zg(e?!֗er\\td2Ia4SxN:w293*̮r]Qjk،f)ΐ`c#< ^V'/9*jFV"&g)Dc{{OzG'E9z++ᓕDi3#'kLuaCnS)J2Y)mULivRi ĹJM"mѪ`lMV[.i/aU`Oo2h%Əνsl7,\銷\1=tqLULb lߵo-nSgoroDDܚmcTpo={CtěTxu\c\UʢLSC##E6hgNj}1qU]x4ڽ;X^]4S-4L"5FQ SM#Tkrfjs2P*?( 1mU_l^PÀ=:WrEbٵr՜nm^ N-i+68mZWnuzbw{&p7;ok}[tnG0UNmȷLM5ًqkM[b#ޥ4:"DsB&ftt ޹t ޹y+p7{)E[N< _3>ģ;w"u]"i׮01vEs:#^=ʫ"-ӴXs11hve7,Jjj͛Zf"U93ܘ֬>VncS];jLjS:2'/*UQ.1]STjGrtѢ;}3~ԙR#h^k6hT3b#dDo$ysQk>~Z򏟄բy_jJQWjKG?:-U4\7!Mec6f-,-d9\W<9覩f3zUiƖ3͔/Z>29Jm4k/j)ͦ |e)fG%M7db)y0w2zr*阊*iqkk]5є8 FNQ䨊(L73}zbc6&f Ҫ`lMV[.i/aU`Oo2h%lVFe)U~Q{b%=/si{(r4si{(rsi{(rsibZܱr.Xj[)<3&9UΞWTZb&7q/1l8WܜX]+^²|;gնw4WoJ[})ބնw4WoJ[})ރ>Wܻ/^Y96uenQMb^Rv^m VE46Ri"b#NVjrD^p`q;GZ38g=gնw\vFv굞gGpq;GZ3{W%;m;#x;GV38g=ϫlk<Ύcoc9ǵMQfSS_fQ}!?C[jr,gJ5Rs*<:c<ȎFh]>Jwϫy6#kO";(y FYrS&}\񵧑ZyCZ6zϫ3~^GJwϫ~3%ZgզyԪ`;EjW?'abM_;xYu}>hO&UXۗ*ݺ)ߘLSjc]uSMUjjkf'^zxeNtgD^b6^=a/h,V]dۍƻo"M1MS;Ӿ2fUXynw&uն+uJ)\ښg"q &0ߦ?{G~?Uhb#4Uy^pY֖ZQ+6Q_^| SMF314hU3gp 9j")D9J2SVeUf&ҩ#2*rJ4EY*rMY|W4WNu3ggc"8{d(d뮨i3h8:&.ئ)r|."͉ch1p>SrdMDLLLLaDժ`;EjW?'abM_;xYu}>k7-/UQcULL3==jFtLoLNɾdQojU3U;h^iKݹMؔWEnhk..ιLQN4uƮujgb:1T1w 1d[`ik98xQV"+*sU5MQ鉙ծxg_LNrTf&ft[U^v i 1 oGHt/ 2cǽMw鉚b":N FN2ww"5U5ttn?YͿKWxfg6*hyUs#^l[fͦ>MڜK&-DU]5tWNޝSzN%jS+5DU3Nlw,ǩ1nah\KڷK6(߈{`%qZrQySV&wgZ٧_HzO}٧_HzOV_+ghtʷ960Ex(f読[k#~k|-/܋Ug64ٷM]K剣#M|hLLo1?{zG~? hcDfn;'~W\5p'QEQ3+hюwj(c'5]nS+sf'3;:4ʴ5u\,Y. +:Ֆk^-W[<dh8+FJ5S<:lfg'v>i`3]bp^K^rrY)"e2{&ӝms'ѓ*+ehOU< U5e(r:hi*3Ͱ@dଟpvS-戚hϧ'LWMV:'6&0a h֪`;EjW?'abM_;xYu}>h 9O'B@yj,Х]3כBZUra_|=ـvi}٧_HzOV_+gha)ʽ=2ubR1k>~}_(EZ'/4FhLP5ת`쎺#NDϚddOkezŋ岞eL](G'߈~^7J9?>C4(G'߀f~~&5[ڧ^{2>>U*tEuZEl2zb},yG>xӪdN]lnx-`<#ʎŬW+':u\cb-`<#цTv-`tY8Ӫeמ OFynGF2qkU˰l?eFdחrb)UU3'cv^Bru_66ӆ)#%9kynG yLy+MQk+.8kʳ&2%8}',no1Ek&2㉱~̫PUt,no HqؿS\Uq6/9}Jc^JřM 8kʷMQ{@hUF\tkb:V2>X]ǜY9^vJL^_ 51LM S{8{d|~i=U=_)޽ʿdwUd|~i=i>N?4誇/^LD WMqC8{{S{2{%\m6GwEE+Mt=$銐O[\/ =O#UC{F&ȲCɴsezCɴse쀸[)VϢ>U뻟EP*ofl伟GXil Ѫ`l?MjIo'a5byMo2ev0g\;Zbr˓E15N&6s}Ek״*1Vs+UT3L^pͷ!aDDͤdlp+\Q69\\&{7D5]sM6ꢽZDt&}0lL\/4e8V"*{i37*\FO,VEʭi:2VmM5j;bߍkyE p6hE;+Fܷk.i1MZ"yY4fdaՍmĢU\ܘuNuNzz]oUTDƍ|:"f#Ky*^Ky*^y'Of5i*눿'vm{[2UW3 vj[\c͸`zw v*Ϣ]#<=O#UC~F&ȲCɴsezCɴse쀸[)V}qw`R].W{5_e%=Ke9Ӫ`l?Mj[@߹ݻT][{gު!{wJ&bmmvaoYS1` 8xSv78s›/w{rGMiMH111 הU<)r{MT㗻=9 qSm;m}DƘ7u+O nxSv78syBAN&kbcLZ[o%Q|ݍJ9{շMUjկt' <^fI yG>T-ũІ ݇O47:i{eb8}13Tg ũSxMS7[r Q hgWL:t4,N / 9J#cɕ3sND%W29hn*8;ẓ#9,K,Y:+Z)sb/]UZc:1oफ़<y,Rcs+2tU4NC! צ/h03͊s6&lUUL̀ں|/5Y:8v[ YeY5i yuT馬ONJ+s2%O]Luu82 )GpUUryrNeY9fmn r+]yXU\q47Rד'%\WG U\EQb wx. j\JhӕH']"`.dhdQ<v EqJiC_2f3hh9W*WkgQT6U qGeiכ3tVfw@m1i؀k=K2ΊETQxfy:< x*hՙ+3Dlf_6qUy 'zϞ'VJ"#'NR'6&TE7tջ8a/֏Y5^W#LO-OSET3UL64:U5ܱTSx5)ҷde*զ6BuV{e0LlNl:y!5iGhL!0ɳ͇l`@Bv Ъ` ଇSLe3yve2h yM9L1+L^DhaNceY*r<S|2jfb. T3wc}4:c[Dk臊.[G]1/W7ת*ə|wk\]:{v//ִdr̽4ͦo:}68DB"m.YDuQTm;Q=f-߀nf-߀@s7s7&-߀CZ)vs7ު)mݐxnfo M幛nfo:P1[no3wc}/ZEf. oLcWES;U;ZN"b%qY8U&/ ޳")j+lrQ]7wlcTụ}~Ojix䢺/{l-GDh4V&m몭uծy=JuՔkoUSy)3Ml&P@&@QnMlv'bҪ`TyzN< -Cg)?)dMT6q5FkE| |/pfS. CJ2U䪘32Yc:5nu32)2sfU]фJZY9*g-]q9 ^|朥Y8fUMS333yQFSOO%39vޫ#Jxd2WfW'MVZ2(DE3εCNpgXfeiWpU5e9Zf|j-TE^s-_gULU<1efg:jV r4QWES2v;g z#>~Z+܎G'eM|6i)MuOXGem4U>kkEk+2:[#8lLMTӛm'e1^[%ܶK6 LӍf@Rழxpn[-SFZ4d5fQ鈙:xzŜZkՑe! U|.)3]33:g+2 | સ|Z*s\tL_aG|~x##܏WrYjmO UNmycYj6_ryNu9Y')&2Qz*/y0< i~+<EW#/S<2Wf:Y[%p]|^ c%<9]TDLFͦqb1фC7+ַ+ eg%L3W^b3Yeu֖SV\Z[+3:"γN>!p.C2+E9xrpcNs*8+'\\pSF14o8-]b^88nVpG?d&b*E11{3vx'.*O!ֆOSzڻa"ozmNKMWp}< djU:-Ey:>N1m<G!.x.μUM3L_:j{lX<3UNrY6o "g fߵsև:ec)GpTdr1nM6 pl<9, \ Uu3qU141}Z -UeqTӄM3N,@C  d k7Mf&o;"@fSl'8#-pTW9*fj&"f7:/@N+א)ejΦ=zbΨ2L!0ɳ͇l`@Bv Ӫ`&ɦ1\wQtptce2)L6Y.')tdcd򑓫)5S~S3yl زMJMKJ%we-dU42U1jS138ꉶ&ZPm/UF;y\StQ'YLcɋ6 S-O&Ofu4m7|ZPm%&ZPf&夝(ٰpX| eWp\d2E<Y di)j*pw&x)ַYce#!}4exΚ)%VhG>zy,|d(]sgNJ}hU]r<BF_/H͉f"3f[lnz? >[)քpJiB"fo7[Pdx )gx/דEY. S 8i:5ƣ~ N3rV^hEQ6wN ܧ:d2'9*/%fȽVͺ6GzǞ/d2Q\N*T;biE2c9<<I*HbW ~<  \9*'2s"鉝ꖿG[G/ETK8'M:6 }lXfu^Jrp2tUSǓ)LFt:zև[꫊9.LΌ'+4Q9N74j>8;#֕]iOU]UMQLM=~-17ZUzQwZ|  Tc/bJEv1fq ;N 㬪8:N^2wUDUEX~7r|^Wo^V3;4TD_7Sx+:-d'VR(2dՔtq|Q :zx%Nfr|3'FRhs&;GpW֗88 +pOge)' 6*'9f&bfKN/Db2y:rtLF0b6,g<ɳ̀E زM Acb6,dԪ`7>8|~JpfC/3nc_' #|Rry> QULqUVEWfvr[< Kde'/SVRb# CoWZmi~ 䩪*͢h4LӣF ^|OZry\S2)DWקt=cy xS+%xEb&/xg+*x+#uVWk~ME6EhU^>/',3Nge+9&շIQpt73hdjȅ&U Guy~| NW W1Yѝb^#6in,Zd7!%GdpVG'ULtjg)QT#6ezqLFml^뾴kuFO'9Zj림h5Z/8/_\ 3 VWrQF_!qO]k^7uni%9I"g-QijΝSw|kS|墬S%ªhkD_ x#"k<;i?D5ӛ/sfzu>!yr:~*>MRSj=۳.|<֧p9r32yL0͋au֏í8x29*QMUFeN&tNΞ gWs{)/kaؘI=dk)hjm1U3x,Z*x"2}idip\JbopM8)܉WNT۬i๧)98%YJ/ɴ{а^OSS?U{L[sV@3]ap/e2G !+ꧮG^LLm͉Yup~Rϧ#ӝW(;ffLiTK|>j'%|¨5[;)k}Q@+x(gguE9>S#;^^|^ɱ͞@(<iLTLfNrE1k2q5ggcLӅ11-ީӾWpMhUSMEs}8C+iNNLM6\U9hyec-:2SNmp O2?\.Mc@-pUVr%: M#8.rYDc\204'`-9L)e*S{䢊|9x+)!FC)VZd5Ŵޘ-йery yZ/'UUiޘŧi jѐו:ruMtm7"i[ V_)^K%e2_:2uUU6M"2<<]YW+VNm]4diz"&5 r9 ViՌDMlVy8+:2 W2/'Uv&%#<q~erLcuWk͉ppLU9S+y:rtU\SʹM 9 Vf}kpV_'VW%e2t_:2uUM6ꈴZ12|Y\YlC)^Je)4Ez-d2 ޴hN f< D2UUc  6dr)\1=<U!#M'ToTEpx+Tp-1L'!m (79^^B/"og+ߛRrK'-ƜerF-eଅ> ?SzyJgż{&fbVfX}fW<8 '#3{aQ|/4kLpw pOͭb&fmh.fo[ӕZ,RMNmM׀x+^1U+d袜f#8Eb~O-jp9#;D\[U5O]3|إR47drAu #^O+MS8Eϓ),BtMTF¬Rr1la8|YNW!muꦙ^-TŦ glsgV()e2te-]tUM5^/NY~^[!S\mUU18D3pZpWSMylS%M~M*'3tG_DOd2pN/Έp.oe29:ζ^"a9~r JLT\Șp5TS|Jژdj<}1n[!W_io1 (\ ry\S']v͢T7_pFO)NFRvEQ\mbys e(er\S)l+MU^mby+ eiאQٹ:uEs|"^@l.+. eiWQՓ+3Wp]hUXU7)lrd2FJruEsCQ~upm1<9ixeg/r\.Mc O2?\.Mcલ29(5ƛ_S\^Zr2eQki6-ɳͅ|p^W+VG'ו';'NN-ޘ2 ^BVNӓki1;h.r\YlYC)^VdUtm7"ippEuY R 䪪2]WT13|f pNJ-M53f'(p_df岔M^Nkm\ rYlNjveuS~m/Y> [)bΛJ;y\FBe2ys+m(V_#MTMZb昞lDK##Lӓe2tΘI4dJ(&M%@z8+2TU+]U{MsxQ\rtk'UDW1L ^بOENJREuE3}78/)e#'7]YQ(hଽ99FVΚ"qܽ*xm|+yMpO \;)lm̽Y~xm|+yM⢸>x#%?'ekQy;g`6^-3\W/+Rb#!JiEJwNO[]i&#KZy~ O6uUZk62'=ou1iC6Oe?, n"̭taLe# Xp^ Ӓ)'MM|"hUFS]֮Z-VC-DZ8!U8nf5S[j#'&RtSWd"aQ_>Rg f4f`Ӫ9/oDSLV"o^W"w# [TE-:'-Snfv^ч_u|pYF_/1MUDU<2uy|stxΊ쩕cg)\TӢgchmY\Uu>pV_+M8:11ѸYȯ)G2Y(e&ڊ)sUN^jнzghbvvG />S/h)#US/4S}s7cr~ ^k')\R)EQM{&'e0<_#\J4ߛf#aZ鮼RmUWTkfpE|NRR:+ꚢ&ǖIe+ ?iNJ ଧ DZh|&7eC'K+L+Gp+Ւ"h"oyF|e+fUuLűL\#+V[)VRuMQ̛ݛx$3-'F_fJxrSTELENS+ rY|e"2YlW;#\Dw_'No2 򑕫+]YJmj湚-7g8&eg-1hk:#dM[S9Gx3-gp#e&(i)\gUyu֧butӒ~Ze孓̦im: O"rRrW5՝os"ryN29nx''lF/+9,Y R0QEWYy .e-ZC#85l-`"2R2y:8#)xvSOcϫ;fݰp?+.+z2\ 2h*qQ1>cua`>BrxWV}YI#6k h:8/#)9Xe#):kϜor 2-Zkꊦfe85ଌK!OW4|Qi׎,[-FK/4WLe2y\y:SVagQ9le*kꊦ7fGEW-)U\WTU77y6yۀ:QuT1TJ8/2UU]lWꩮ׌O8'%UUQQUszꉙ3UdUZf晞lĨSe2s_N:LFB&2YlN'NeuS~m@nzE~bfƉ|O-kveuS{_MMfU13M1m}SN篇k;m]v,\kXv(DZ5G&y3/UFS-xZ5LN > i2YZozhiJQBO#%LѓEiꈛDMuM1L131&my@ת`6rE5ehūJi)h鈼1םf]y,S'if~LӝMc:Sx Zhdg'_d+q:(ryJdjrTi܉Nf֗[ Z<e*S4d'2YN Ȧ8d{N8[h:Gu 4gO^FL3fNG8uֿFK^NKӗ- x##TgMjc]{*%TfK2yLB)1MDa:maɳ͇lc;Ъ`<hZ^bb"63}5TWMrX9\sc XQ͞ jΎ O:;Da MljhLu7e2|y\d',K+-DLM4ͯt?-gpT7u9\V#%8sXVd) >> c/^V̝Qx \ȵ~X?YٙlYy<FJ)K-dL^v #gNSNr<؜b-3;"x#d*5YHcQLU4b"tuyj8%FfW.VtU\DDsfj(8:rI+%̿'e*J"yp_gXdWY|lwU9:+j"h/F3t!8d*rWDso7Vi]m=ke)q>Ox'drz':_.)urE5L岖b2qhFe8sz#/_ZjڣfG#1*uֿZ\?WFG'4e2y ~J"fZ"/Z'L^G+#recs'MuyJf&aE_J N&Le""sy[/Jz7 '| qY|i)M1LMTEQ86ѵg'#8 ]9\u(jU18DmSWj[8><'+efӓ̦)ݚ^Jx,STSI+U+UUm_'d8+)iD4e隳g6)n곁C-ZxY|[%EQ]x34N T8/NV岙i:b)DDΘř ÁuGkW k)4aN9i^uy n ʸ3xŚi%;;;}Ox'r9I\8m8'U h#y+Q{UM8Uf2U4N)13Efѻ 8x+&OU9,f/Χ60ܺ{N:&_N 9!:= LGhΞtv<<^ɳ̀yN¿V/eS)VN"N^f" .8)NRe+B2QLfzj 79_/WY^YQLc/'MTUVfvNisUl' Ӫ` >x /UM5QTڊsMQ3j/}e2xr5e)U2NMƅc-bLuDNU387ukNE7o7fz3yos77o37o=U8Sٻ/Uh"f~fMg[ȿ3x(s77o/@ YټZU|Χ6ka^p ,S\S&;lstn_N M7oo s7|#FyNlw3y&;~f@S8~f:y ~f@ 3x3y=D7~fߙ_~f~fNw3y'΍1<<gs77s7o5UQU4N֩b'=$ǻ].[i&ׯrl[TjUTսkU7_us^u9mo'funnA;.##T[HmMZuxvvڢ-ڦ(M4SLG]䘋E8/8-VRٷr \֯u~8p'/1LZq,J*c-)q[ׂs)V[GJWbLY_}guuC73:-\5UՓFu36Z + )4erSI]4*LeZbu·XqS5Lp/NFʳ\8xMXZc:td6)4[g6G3b6n>6ʣ'\W!U1J35c8DΉz#!Z8'1<uDSêNd&ƹӎԪ`TyzN< BPZ)vVy҄Δkji(\ TdW:r\Qj%lsg duG6{d'Tsg <@&@QnMl𻛉f(5DO<ܮ-E꧱tʪ]UL h<4SM9U:- ~hLS3HFx*bbx&765~vXuniz\v^ ѕth݉EZ.h\opOYHpNNruՓ\^o9#̵}g^x/!k9L\EyLWt]p_e/_E9\ڪoZm}4ƽGU,hkh3bz-֗UGd8&观/1|𼝫Fl^kqZ1ۨ>C-֌W \yDWDUMqxU31<_X\֎G>NY.LDDe+fThb=/Y7ͪc+Nz(rugp?Xy\K#ϫ!\Ӕ>TLŧ)3cl::~ՑY,:i-8؝S<FO)p7pMU2FfJu/:"fqsr<8MUdY ra5F3s'Tl1@ժ`TG94'8'6p O8p!;yCZ)vy8$'J:t@q }~Wt\e銦ζVjbcf8|<z3VjbtZ"qYsy8'95l"y O8 <:y#9<!19<'sQɳ͎@q { ٹLn*[]FO)e%+wt0/cEzurmJ'R6-KQf;Zc33̿`T"b""-,a8#> j7/O ͪ#M41̊ad%,uGZ|7-UL3c/gQpO<7 lJre&2FSզz[F€ U'MQs!%DZ-4#u낸;-=YJEU5Eꕨ ޴x##9jjS3Ddk613<y24dg%V[#FV3&iFň/C+nSr4妪{vpvWՒdg6#7!%Fi_uj֪`TyzN< ԄS;y3 ( x*2>9N]MTUDN1+%Yzx.2NWk"mg "qXQ͞ gO:;D&t@&@Qy6yۀ:\=/~nN᪚"wƹ}&"gcTFELQUtSǀF7Z"(7o9N?:rh"fcc?Eaݱv6]1OK}Օ!D察&pT(\Odh)*k-͞Z16[CFK3!|er['TZ+FFRlMb$\ 2ielp>C'gS:*)3LN,_YQU_NZrNNN3iϘi6 SEy,dZ')]3NS C[n4pNF8+)l9Z2uh&bb1} np6KଆFY/h+Yu/)O 'eg'9*&h5Z&o_ҹS-lrlR2| ()DMy^vW=,XhSoW)Lג'e"\/+LTӻsg!M|4jhg2QL Ӈ_k:jp?Z4FCrTUd1ਜTDDqfsdDD7SjY}up\yRKSO7'U^373n7%2䩢'/=~kESkmm2 `ת`TyzN< BPZ)vVy҄Δ8'%\ehϜՓf*E'b 5<џø::UULX%buG6{d'Tsg <ΎBa=Ggy6yۀUQLMULDDk與]u4^1ncoU[YWKөW%ebM4Z `cѺFƓY]jgp=:&i-11l%Y^BdiS5Q1yƛ1 Q+x3x!FSY)U11z:G~lpnK2s*Its#Fcn >_+w WNu|٘e9NhG']-2d[6X3+֞Oۍ&;:j&EU;LLe8+cx}UӔG)LgSTS]N7t/x'?G<x#39MZ*+y5M5M}WЪ` YQqLUèϚ8^nt_:"/ki6\S8))FFidxTe*+1U1ELdw:8LpNV)iETWN''z1pص_^twNpO]y wN]: 뻧]@]wu5ZZ)v뻩뻯 'wu'n;utwSw^@O]0@ ༗Q]_Zt©ٚ뻫68 j%ZjwSw^@O]O]yZ4闔laa:z뻨뻨m;DuU=wu=wuuאۨ뻤 wNwPpzfΝ0MlvuӮawSw^Gb;UW-WE3;Ѯbb5΃~kYL]311?~W\LU4Dv kntNtWSl,)jMvESǁ}Qeg-]U:5Nto]ipVC-֗u19e/6N){&&׹) <ևx^KԌpFTdQ1&3pzX>gN[sp/ӢJ()D1\WD{N6 K29>x*2Iës5NtZpl^7Oe dNdUWE63z&"ыIY_[-\K)dꢊLf17bWf*2|.8/dg)9Z&(Ƭ& ŭ"4ӑi6'5Lqm|MyN获Y~-ёhr5-4k־BSֵ<xr-e舧>rVxuuUU[NsѪ`TyzN< BPZ)vVycϢmUFMwiňֺ53:&5t.-<W umY|9w4 QrS7<^0 ;Gi{E\UQ5DkrnrEYV;4TU13TGI.ΣDpDdΌwNᙳ}8_Jxd=~o}s}Nb1:33&[{yNf2ɮ&t3 Jx*33Ւl꩜7s^Q VKMU3Ր 퐝Q͞&<@&@QnMlNҪ` ܋^/k p_drU9UV|sVFFR('gSg 82 9zjDUU\uDSUz݋&f܅8']fbsbb43}^wQ\6R|FϚig+]Tt舘Um%qZrS7)UhULYl GOfp5Y-6ΪMde'j2yJj-3rq4Zb׽5aik.S+ë'1^R&uLcTDY&Y9 G)MuNf9#)2}v'U8Nlt(_d"824U3&/־|/e0 K#|ӝ-)Mz"er+++.Mu1h/3Eb]pvR2zo"o5_6S33k/+PӪ`b^XQ߆Փtį8;3pJr𺲵StdLEp[| |tFKS6K)lS5DEShO)2]|艙ίLS3'x,[g29~ 99c/kO|\kbx rY~ + le&/FoLDL[jd. (p&ֶ3E8Nh|_EYiQ)LͳS4iMMް笮^ 6Z溧/^O'LUNi;g7T:7)\y F^:h~Vs+&m|ܬQ[:4ƿOZM4QjryHSZϋZm7pS VwH:G1VL3OX:6( DVS#+Z'E5kKڪY K%1M4#%USW ؙVb endstream endobj 1380 0 obj <>stream endstream endobj 1313 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\034\002\220\006)-10(\026)11(\016\001\025\017\001\013\205 \024\220\n\002\025\f\220\025\026)11(\013 \201\220\r\016\002\026\220\n\215\007\025\r \221\002\220\022\r\025\006\ \221\013\007\220\026)11(\016\007\216\001\020\207 )]TJ 0 -1 TD [(\025\006)-10(\007\025\217\001\016\001\220\205\207 \201\220\r\016\002\026\220\n\215\007\ \205\002\001\025\203 \f\025\007\016\222\001\220 \(\221\220\007\025\026\001\ \025\016 \220\006\006)-10(\007\016\201\025\r\013\001\220\016\))]TJ 39.309 1 Td [(Mucosal micr)20(obiota of th)11(e div)12(er)-20(ticula in inflammator)-31(y )]TJ 1.089 -1 Td [(complications of div)12(er)-19.9(ticular disease \(a pilot study\))]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0.275 Tw 10 0 0 10 42.5197 225.5319 Tm (\017)Tj /Span<>> BDC ( )Tj EMC [(\221\017\n\023\f\024\027\026, \023\024\022\026\026\021\036\035\034 \235\ \017\035\024\020\036\027\036\021\017\004\036\f\022\024\020\024 )0.5(\030\026\027\024)]TJ /Span<>> BDC (-)Tj EMC 0.086 Tw 0 -1.218 TD [(\024\002\030\026\017\016 F)19.9(ai)-23.9(t)-13(h\245s PD \017)]TJ /Span<>> BDC ( )Tj EMC (\022\024\035\017\004\036\f\021\r\024 \210\230\213 \(\024\023\036\030\026\ \006\017\024\027\027\t\b )Tj 1.044 Tw T* (\021\026\022\f\024\027\024\n\017\004\036\f\022\017\b \036\007\017\027\017\ \006\). \202\035\034\235\026-\030\026\027\024\024\002\030\026\017\036 \ )Tj 0.197 Tw T* [(\n\017\022\030\024\002\017\024\021\t )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC [(\024\002\030\026\006\036 )0.5(\2251 \002\t\035\024 )0.5(\007\024\f\021\024\r\036\030\027\024 )0.5(\r\t\001\036, )]TJ 0.13 Tw T* (\004\036\n \r)Tj /Span<>> BDC ( )Tj EMC (\007\030\031\020\017\b \024\002\030\026\006\026\b \023\024)Tj /Span<>> BDC ( )Tj EMC (\023\024\022\026\026\021\036\035\033 \r\017\007\024\r\024\020\024 \002\024\ )Tj 0 Tw (-)Tj 0.164 Tw T* (\020\026\021\f\021\r\026 \(\022\024\035\017\004\036\f\021\r\031 \024\002\ \027\026\030\031\032\036\027\027\t\b \r\017\007\024\r \017\035\017 \210\230\ \213\), )Tj -0.002 Tw T* [(\023\024\022\026\026\021\036\035\033 )0.6(\235\017\035\024\020\036\027\036\021\017\004\036\f\022\024\020\024 \030\026\ \027\024\024\002\030\026\017\016 )0.6(F)20(ai)-24(t)-13(h\254s )]TJ 0.171 Tw T* (PD \(\022\024\021\024\030\t\005 \031\004\017\021\t\r\026\036\021 \027\036\ \021\024\035\034\022\024 \004\017\f\035\024 \030\026\035\017\004\027\t\ \b )Tj 0.27 Tw T* (\210\230\213, \027\024 \017)Tj /Span<>> BDC ( )Tj EMC (\017\b \021\026\022\f\024\027\024\n\017\004\036\f\022\024\036 \023\024\035\ \024\032\036\027\017\036\), \026)Tj /Span<>> BDC ( )Tj EMC (\021\026\022)Tj 0 Tw (-)Tj 0.146 Tw T* [(\032\036 )0.5(\017\027\007\036\022\f\026\n )0.5(\026\035\034\235\026-\030\026\027\024\024\002\030\026\017\016 )0.6(\223\026\0241 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 18.146 0 Td (\234\036\027\027\024\027\026, )Tj 0.173 Tw -18.146 -1.218 Td (\027\024 \027\036 \017\027\007\036\022\f\031 \221\017\n\023\f\024\027\026\ \(\230\026\002\035.)Tj /Span<>> BDC ( )Tj EMC (3\). \212\035\016 \024\006\036\027\022\017 \002\036)Tj 0 Tw (-)Tj 0.884 Tw T* (\021\026-\030\026\027\024\024\002\030\026\017\016 \(\030\026\035\017\004\ \017\005, \030\026\f\f\021\024\016\027\017\016 \n\036\032\007\031 )Tj 0.658 Tw T* (\f\024\024\002\013\036\f\021\r\026\n\017\) \030\026\f\f\004\017\021\026\035\ \017 \022\030\017\021\036\030\017\005 \027\036\f\b\024\007\f\021\r\026 )Tj 0.07 Tw 23.244 14.614 Td (\207\030\036\016-\025\201\030\021\017\f\026 \017)Tj /Span<>> BDC ( )Tj EMC (\f \036\020\024 \023\024\n\024\013\034\033 \031\f\021\026\027\024\r\017\035\ \017, \004\021\024 \n\017\022)Tj 0 Tw (-)Tj 0.725 Tw T* (\030\024\002\027\t\036 \f\024\024\002\013\036\f\021\r\026 \r\024\f\023\026\ \035\036\027\027\t\b \007\017\r\036\030\021\017\022\031\035\024\r, )Tj 0.252 Tw T* (\023\024\035\031\004\036\027\027\t\b \024\021 \030\026\027\t\b \023\026\ \006\017\036\027\021\024\r, \027\026\004\017\021\036\035\034\027\024 \024\ \021)Tj 0 Tw (-)Tj 0.094 Tw T* (\035\017\004\026\033\021\f\016 \007\030\031\020 \024\021 \007\030\031\020\ \026 \(\217\017\f.)Tj /Span<>> BDC ( )Tj EMC (1\202\). \200\036\022\021\024\030\t \027\026)Tj /Span<>> BDC ( )Tj EMC (\007\r\024\005)Tj 0 Tw (-)Tj 0.102 Tw T* [(\027\024\005 \007\017\026\020\030\026\n\n\036 PC)20(A \007\036\n\024\027\f\021\030\017\030\031\033\021 \f\036\n\036\005\f\021\ \r\026, \022\024\021\024)]TJ 0 Tw (-)Tj 0.064 Tw T* (\030\t\036 \r)Tj /Span<>> BDC ( )Tj EMC [(\002\024\035\034\001\036\005 )0.5(\f\021\036\023\036\027\017 \024\023\030\036\007\036\035\016\033\021 )0.5(\030\026\035\017\004\017\016 )0.5(\n\036\032\007\031 )]TJ 0.235 Tw T* (\021\026\022\f\024\027\024\n\017\004\036\f\022\017\n\017 \023\030\024\235\ \017\035\016\n\017 \024\002\030\026\006\024\r \(\217\017\f.)Tj /Span<>> BDC ( )Tj EMC (1\207\). )Tj 0.306 Tw T* (\215\030\017)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\n \n\036\032\007\031 \f\036\n\036\005\f\021\r\026\n\017 )Tj /T1_2 1 Tf 0 Tw [(V)33(er)-15.9(rucomicrobiaceae/)]TJ T* [(Bacteroid)26.1(aceae )]TJ /T1_1 1 Tf 7.08 0 Td (\017)Tj /Span<>> BDC ( )Tj EMC /T1_2 1 Tf 1.653 0 Td (Lachnospiraceae/[Tissierellaceae] )Tj /T1_1 1 Tf 0.614 Tw -8.733 -1.218 Td (\024\021\n\036\004\036\027\026 \027\036\020\026\021\017\r\027\026\016 \022\ \024\030\030\036\035\016\006\017\016, \026)Tj /Span<>> BDC ( )Tj EMC (\n\036\032\007\031 \f\036)Tj 0 Tw (-)Tj T* (\n\036\005\f\021\r\026\n\017 )Tj /T1_2 1 Tf 8.361 0 Td [(R)22(uminococcaceae/Lachnospiraceae)]TJ /T1_1 1 Tf ( )Tj -8.361 -1.218 Td (\017)Tj /Span<>> BDC ( )Tj EMC /T1_2 1 Tf 0.769 0 Td [(V)33(er)-16(rucomicrobiaceae/[Tissierellaceae] )]TJ /T1_1 1 Tf 0.018 Tw 15.236 0 Td [(\022\024\030\030\036\035\016\006\017\016 )0.5(\027\036 )]TJ 0 Tw -16.005 -1.218 Td (\r\t\016\r\035\036\027\026.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 9 0 0 9 42.5197 730.483 Tm (\020\004\206\f\t\204\004 4.)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf ( \255\t\021\n\027\021\020\031 \024\026\013\t\n\021\020, \n\005\021\026\032\ \205\204\031\021\021\020\031 \027)Tj /Span<>> BDC ( )Tj EMC (\030\025\027\031\032\024\025\013\205\023\026\004 \t)Tj /Span<>> BDC ( )Tj EMC [(\033\n\003\n\211)0.5(\022\007 \t\031\013\027\031\021\025\032\n\027\026\021\025\002 \202\031\021\ \026 16S \032\025\005\n\t\n\003\021\n\017 \212\217\222*)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0 -1.2 TD [(T)48(able 4.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf [( Ma)10.1(jor tax)10(a detected in div)13.2(er)-40(ticula by 16S r)-36.8(ibosomal RN)15.1(A g)12(ene seq)14(uencing*)]TJ ET 0 0 0 1 K 0.5 w /GS2 gs q 1 0 0 1 42.5197 709.5118 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 42.7697 698.0425 cm 0 0 m 0 11.219 l S Q q 1 0 0 1 127.8091 709.5118 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 127.8091 698.2925 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 161.8248 709.5118 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 195.8405 709.5118 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 229.8563 709.5118 cm 0 0 m 34.266 0 l S Q q 1 0 0 1 263.872 698.2925 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 42.7697 677.2233 cm 0 0 m 0 20.819 l S Q q 1 0 0 1 127.5591 698.0425 cm 0 0 m 34.266 0 l S Q q 1 0 0 1 127.8091 677.2233 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 161.8248 698.0425 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 161.8248 677.2233 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 195.8405 698.0425 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 195.8405 677.2233 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 229.8563 698.0425 cm 0 0 m 34.266 0 l S Q q 1 0 0 1 229.8563 677.2233 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 263.872 677.2233 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 42.5197 676.9733 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 42.7697 665.7621 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 127.8091 676.9733 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 127.8091 665.7621 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 161.8248 676.9733 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 161.8248 665.7621 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 195.8405 676.9733 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 195.8405 665.7621 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 229.8563 676.9733 cm 0 0 m 34.266 0 l S Q q 1 0 0 1 229.8563 665.7621 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 263.872 665.7621 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 665.5121 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 42.7697 654.3008 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 127.8091 665.5121 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 127.8091 654.3008 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 161.8248 665.5121 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 161.8248 654.3008 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 195.8405 665.5121 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 195.8405 654.3008 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 229.8563 665.5121 cm 0 0 m 34.266 0 l S Q q 1 0 0 1 229.8563 654.3008 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 263.872 654.3008 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 654.0508 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 42.7697 642.8395 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 127.8091 654.0508 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 127.8091 642.8395 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 161.8248 654.0508 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 161.8248 642.8395 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 195.8405 654.0508 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 195.8405 642.8395 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 229.8563 654.0508 cm 0 0 m 34.266 0 l S Q q 1 0 0 1 229.8563 642.8395 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 263.872 642.8395 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 642.5895 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 42.7697 631.3782 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 127.8091 642.5895 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 127.8091 631.3782 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 161.8248 642.5895 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 161.8248 631.3782 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 195.8405 642.5895 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 195.8405 631.3782 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 229.8563 642.5895 cm 0 0 m 34.266 0 l S Q q 1 0 0 1 229.8563 631.3782 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 263.872 631.3782 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 631.1282 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 42.7697 619.9169 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 127.8091 631.1282 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 127.8091 619.9169 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 161.8248 631.1282 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 161.8248 619.9169 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 195.8405 631.1282 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 195.8405 619.9169 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 229.8563 631.1282 cm 0 0 m 34.266 0 l S Q q 1 0 0 1 229.8563 619.9169 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 263.872 619.9169 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 619.6669 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 42.7697 608.4556 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 127.8091 619.6669 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 127.8091 608.4556 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 161.8248 619.6669 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 161.8248 608.4556 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 195.8405 619.6669 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 195.8405 608.4556 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 229.8563 619.6669 cm 0 0 m 34.266 0 l S Q q 1 0 0 1 229.8563 608.4556 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 263.872 608.4556 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 608.2056 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 42.7697 596.9944 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 127.8091 608.2056 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 127.8091 596.9944 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 161.8248 608.2056 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 161.8248 596.9944 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 195.8405 608.2056 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 195.8405 596.9944 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 229.8563 608.2056 cm 0 0 m 34.266 0 l S Q q 1 0 0 1 229.8563 596.9944 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 263.872 596.9944 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 596.7444 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 42.7697 585.5331 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 127.8091 596.7444 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 127.8091 585.5331 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 161.8248 596.7444 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 161.8248 585.5331 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 195.8405 596.7444 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 195.8405 585.5331 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 229.8563 596.7444 cm 0 0 m 34.266 0 l S Q q 1 0 0 1 229.8563 585.5331 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 263.872 585.5331 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 585.2831 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 42.7697 574.0718 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 127.8091 585.2831 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 127.8091 574.0718 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 161.8248 585.2831 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 161.8248 574.0718 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 195.8405 585.2831 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 195.8405 574.0718 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 229.8563 585.2831 cm 0 0 m 34.266 0 l S Q q 1 0 0 1 229.8563 574.0718 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 263.872 574.0718 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 573.8218 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 42.7697 562.6105 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 127.8091 573.8218 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 127.8091 562.6105 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 161.8248 573.8218 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 161.8248 562.6105 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 195.8405 573.8218 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 195.8405 562.6105 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 229.8563 573.8218 cm 0 0 m 34.266 0 l S Q q 1 0 0 1 229.8563 562.6105 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 263.872 562.6105 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 562.3605 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 42.7697 551.1492 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 127.8091 562.3605 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 127.8091 551.1492 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 161.8248 562.3605 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 161.8248 551.1492 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 195.8405 562.3605 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 195.8405 551.1492 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 229.8563 562.3605 cm 0 0 m 34.266 0 l S Q q 1 0 0 1 229.8563 551.1492 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 263.872 551.1492 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 550.8992 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 42.7697 539.6879 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 127.8091 550.8992 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 127.8091 539.6879 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 161.8248 550.8992 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 161.8248 539.6879 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 195.8405 550.8992 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 195.8405 539.6879 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 229.8563 550.8992 cm 0 0 m 34.266 0 l S Q q 1 0 0 1 229.8563 539.6879 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 263.872 539.6879 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 539.4379 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 42.7697 528.2267 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 127.8091 539.4379 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 127.8091 528.2267 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 161.8248 539.4379 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 161.8248 528.2267 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 195.8405 539.4379 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 195.8405 528.2267 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 229.8563 539.4379 cm 0 0 m 34.266 0 l S Q q 1 0 0 1 229.8563 528.2267 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 263.872 528.2267 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 527.9767 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 42.7697 516.7654 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 127.8091 527.9767 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 127.8091 516.7654 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 161.8248 527.9767 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 161.8248 516.7654 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 195.8405 527.9767 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 195.8405 516.7654 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 229.8563 527.9767 cm 0 0 m 34.266 0 l S Q q 1 0 0 1 229.8563 516.7654 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 263.872 516.7654 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 516.5154 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 42.7697 505.3041 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 127.8091 516.5154 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 127.8091 505.3041 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 161.8248 516.5154 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 161.8248 505.3041 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 195.8405 516.5154 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 195.8405 505.3041 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 229.8563 516.5154 cm 0 0 m 34.266 0 l S Q q 1 0 0 1 229.8563 505.3041 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 263.872 505.3041 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 505.0541 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 42.7697 493.8428 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 127.8091 505.0541 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 127.8091 493.8428 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 161.8248 505.0541 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 161.8248 493.8428 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 195.8405 505.0541 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 195.8405 493.8428 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 229.8563 505.0541 cm 0 0 m 34.266 0 l S Q q 1 0 0 1 229.8563 493.8428 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 263.872 493.8428 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 493.5928 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 42.7697 482.3815 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 127.8091 493.5928 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 127.8091 482.3815 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 161.8248 493.5928 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 161.8248 482.3815 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 195.8405 493.5928 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 195.8405 482.3815 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 229.8563 493.5928 cm 0 0 m 34.266 0 l S Q q 1 0 0 1 229.8563 482.3815 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 263.872 482.3815 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 482.1315 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 42.7697 470.9202 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 127.8091 482.1315 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 127.8091 470.9202 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 161.8248 482.1315 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 161.8248 470.9202 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 195.8405 482.1315 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 195.8405 470.9202 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 229.8563 482.1315 cm 0 0 m 34.266 0 l S Q q 1 0 0 1 229.8563 470.9202 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 263.872 470.9202 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 470.6702 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 42.7697 459.459 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 127.8091 470.6702 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 127.8091 459.459 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 161.8248 470.6702 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 161.8248 459.459 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 195.8405 470.6702 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 195.8405 459.459 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 229.8563 470.6702 cm 0 0 m 34.266 0 l S Q q 1 0 0 1 229.8563 459.459 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 263.872 459.459 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 459.209 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 42.7697 447.9977 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 127.8091 459.209 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 127.8091 447.9977 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 161.8248 459.209 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 161.8248 447.9977 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 195.8405 459.209 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 195.8405 447.9977 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 229.8563 459.209 cm 0 0 m 34.266 0 l S Q q 1 0 0 1 229.8563 447.9977 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 263.872 447.9977 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 447.7477 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 42.7697 436.5364 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 127.8091 447.7477 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 127.8091 436.5364 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 161.8248 447.7477 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 161.8248 436.5364 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 195.8405 447.7477 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 195.8405 436.5364 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 229.8563 447.7477 cm 0 0 m 34.266 0 l S Q q 1 0 0 1 229.8563 436.5364 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 263.872 436.5364 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 436.2864 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 42.7697 425.0751 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 127.8091 436.2864 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 127.8091 425.0751 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 161.8248 436.2864 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 161.8248 425.0751 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 195.8405 436.2864 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 195.8405 425.0751 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 229.8563 436.2864 cm 0 0 m 34.266 0 l S Q q 1 0 0 1 229.8563 425.0751 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 263.872 425.0751 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 424.8251 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 42.7697 413.6138 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 127.8091 424.8251 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 127.8091 413.6138 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 161.8248 424.8251 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 161.8248 413.6138 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 195.8405 424.8251 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 195.8405 413.6138 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 229.8563 424.8251 cm 0 0 m 34.266 0 l S Q q 1 0 0 1 229.8563 413.6138 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 263.872 413.6138 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 413.3638 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 42.7697 402.1525 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 127.8091 413.3638 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 127.8091 402.1525 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 161.8248 413.3638 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 161.8248 402.1525 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 195.8405 413.3638 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 195.8405 402.1525 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 229.8563 413.3638 cm 0 0 m 34.266 0 l S Q q 1 0 0 1 229.8563 402.1525 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 263.872 402.1525 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 401.9025 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 42.7697 390.6913 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 127.8091 401.9025 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 127.8091 390.6913 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 161.8248 401.9025 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 161.8248 390.6913 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 195.8405 401.9025 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 195.8405 390.6913 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 229.8563 401.9025 cm 0 0 m 34.266 0 l S Q q 1 0 0 1 229.8563 390.6913 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 263.872 390.6913 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 390.4413 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 42.7697 379.23 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 127.8091 390.4413 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 127.8091 379.23 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 161.8248 390.4413 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 161.8248 379.23 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 195.8405 390.4413 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 195.8405 379.23 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 229.8563 390.4413 cm 0 0 m 34.266 0 l S Q q 1 0 0 1 229.8563 379.23 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 263.872 379.23 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 378.98 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 42.7697 367.7687 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 127.8091 378.98 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 127.8091 367.7687 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 161.8248 378.98 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 161.8248 367.7687 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 195.8405 378.98 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 195.8405 367.7687 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 229.8563 378.98 cm 0 0 m 34.266 0 l S Q q 1 0 0 1 229.8563 367.7687 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 263.872 367.7687 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 367.5187 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 42.7697 356.3074 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 127.8091 367.5187 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 127.8091 356.3074 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 161.8248 367.5187 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 161.8248 356.3074 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 195.8405 367.5187 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 195.8405 356.3074 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 229.8563 367.5187 cm 0 0 m 34.266 0 l S Q q 1 0 0 1 229.8563 356.3074 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 263.872 356.3074 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 356.0574 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 42.7697 344.8461 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 127.8091 356.0574 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 127.8091 344.8461 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 161.8248 356.0574 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 161.8248 344.8461 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 195.8405 356.0574 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 195.8405 344.8461 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 229.8563 356.0574 cm 0 0 m 34.266 0 l S Q q 1 0 0 1 229.8563 344.8461 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 263.872 344.8461 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 344.5961 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 42.7697 333.3848 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 127.8091 344.5961 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 127.8091 333.3848 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 161.8248 344.5961 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 161.8248 333.3848 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 195.8405 344.5961 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 195.8405 333.3848 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 229.8563 344.5961 cm 0 0 m 34.266 0 l S Q q 1 0 0 1 229.8563 333.3848 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 263.872 333.3848 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 333.1348 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 42.7697 321.9236 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 127.8091 333.1348 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 127.8091 321.9236 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 161.8248 333.1348 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 161.8248 321.9236 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 195.8405 333.1348 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 195.8405 321.9236 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 229.8563 333.1348 cm 0 0 m 34.266 0 l S Q q 1 0 0 1 229.8563 321.9236 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 263.872 321.9236 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 321.6736 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 42.7697 310.4623 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 127.8091 321.6736 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 127.8091 310.4623 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 161.8248 321.6736 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 161.8248 310.4623 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 195.8405 321.6736 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 195.8405 310.4623 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 229.8563 321.6736 cm 0 0 m 34.266 0 l S Q q 1 0 0 1 229.8563 310.4623 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 263.872 310.4623 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 310.2123 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 42.7697 299.001 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 127.8091 310.2123 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 127.8091 299.001 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 161.8248 310.2123 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 161.8248 299.001 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 195.8405 310.2123 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 195.8405 299.001 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 229.8563 310.2123 cm 0 0 m 34.266 0 l S Q q 1 0 0 1 229.8563 299.001 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 263.872 299.001 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 298.751 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 42.7697 287.5397 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 127.8091 298.751 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 127.8091 287.5397 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 161.8248 298.751 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 161.8248 287.5397 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 195.8405 298.751 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 195.8405 287.5397 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 229.8563 298.751 cm 0 0 m 34.266 0 l S Q q 1 0 0 1 229.8563 287.5397 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 263.872 287.5397 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 287.2897 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 42.7697 276.0784 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 127.8091 287.2897 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 127.8091 276.0784 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 161.8248 287.2897 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 161.8248 276.0784 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 195.8405 287.2897 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 195.8405 276.0784 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 229.8563 287.2897 cm 0 0 m 34.266 0 l S Q q 1 0 0 1 229.8563 276.0784 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 263.872 276.0784 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 275.8284 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 42.7697 264.6171 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 127.8091 275.8284 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 127.8091 264.6171 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 161.8248 275.8284 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 161.8248 264.6171 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 195.8405 275.8284 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 195.8405 264.6171 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 229.8563 275.8284 cm 0 0 m 34.266 0 l S Q q 1 0 0 1 229.8563 264.6171 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 263.872 264.6171 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 264.3671 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 42.7697 253.1559 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 127.8091 264.3671 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 127.8091 253.1559 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 161.8248 264.3671 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 161.8248 253.1559 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 195.8405 264.3671 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 195.8405 253.1559 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 229.8563 264.3671 cm 0 0 m 34.266 0 l S Q q 1 0 0 1 229.8563 253.1559 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 263.872 253.1559 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 252.9059 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 127.8091 252.9059 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 161.8248 252.9059 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 195.8405 252.9059 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 229.8563 252.9059 cm 0 0 m 34.266 0 l S Q BT /GS1 gs /T1_3 1 Tf 8 0 0 8 70.7416 690.3425 Tm (\020\004\220\217\002\b\013)Tj 8.906 1.317 Td (\017\003\b\002\217\t\003\r\f\001\b\002\r \217\002\240\r\006\202\004\b\t\r\ , %)Tj 0.075 -1.434 Td (1)Tj -0.829 -1.2 Td (\021, 52)Tj 5.081 1.2 Td (2)Tj -0.779 -1.2 Td (\027, 52)Tj 5.031 1.2 Td (3)Tj -0.833 -1.2 Td (\225, 68)Tj 5.085 1.2 Td (4)Tj -0.975 -1.2 Td (\016, 68)Tj /T1_2 1 Tf -23.904 -1.433 Td (Actinobacteria)Tj /T1_1 1 Tf 11.809 0 Td (3,6)Tj 4.252 0 Td (0,9)Tj 4.252 0 Td (0,6)Tj 4.002 0 Td (11,5)Tj /T1_2 1 Tf -24.315 -1.433 Td (Bi\233dobacteriales)Tj /T1_1 1 Tf 11.809 0 Td (0,0)Tj 4.252 0 Td (0,0)Tj 4.252 0 Td (0,0)Tj 4.002 0 Td (10,3)Tj /T1_2 1 Tf -24.315 -1.433 Td (Bi\233dobacteriaceae)Tj /T1_1 1 Tf 11.809 0 Td (0,0)Tj 4.252 0 Td (0,0)Tj 4.252 0 Td (0,0)Tj 4.002 0 Td (10,3)Tj /T1_2 1 Tf -24.315 -1.433 Td (Bi\233dobacterium)Tj /T1_1 1 Tf 11.809 0 Td (0,0)Tj 4.252 0 Td (0,0)Tj 4.252 0 Td (0,0)Tj 4.002 0 Td (10,3)Tj /T1_2 1 Tf -24.315 -1.433 Td (Coriobacteriales)Tj /T1_1 1 Tf 11.809 0 Td (3,3)Tj 4.252 0 Td (0,7)Tj 4.252 0 Td (0,6)Tj 4.252 0 Td (1,1)Tj /T1_2 1 Tf -24.565 -1.433 Td (Coriobacteriaceae)Tj /T1_1 1 Tf 11.809 0 Td (3,3)Tj 4.252 0 Td (0,7)Tj 4.252 0 Td (0,6)Tj 4.252 0 Td (1,1)Tj /T1_2 1 Tf -24.565 -1.433 Td (Collinsella)Tj /T1_1 1 Tf 11.809 0 Td (2,3)Tj 4.252 0 Td (0,0)Tj 4.252 0 Td (0,3)Tj 4.252 0 Td (0,0)Tj /T1_2 1 Tf -24.565 -1.433 Td (Bacteroidetes)Tj /T1_1 1 Tf 11.559 0 Td (16,6)Tj 4.252 0 Td (17,6)Tj 4.252 0 Td (13,3)Tj 4.252 0 Td (42,7)Tj /T1_2 1 Tf -24.315 -1.433 Td (Bacteroidales)Tj /T1_1 1 Tf 11.559 0 Td (16,6)Tj 4.252 0 Td (17,6)Tj 4.252 0 Td (13,3)Tj 4.252 0 Td (42,7)Tj /T1_2 1 Tf -24.315 -1.433 Td (Bacteroidaceae)Tj /T1_1 1 Tf 11.809 0 Td (8,0)Tj 4.002 0 Td (10,7)Tj 4.502 0 Td (9,7)Tj 4.002 0 Td (40,1)Tj /T1_2 1 Tf -24.315 -1.433 Td (Bacteroides)Tj /T1_1 1 Tf 11.809 0 Td (8,0)Tj 4.002 0 Td (10,7)Tj 4.502 0 Td (9,7)Tj 4.002 0 Td (40,1)Tj /T1_2 1 Tf -24.315 -1.433 Td (Porphyromonadaceae)Tj /T1_1 1 Tf 11.809 0 Td (1,4)Tj 4.252 0 Td (3,6)Tj 4.252 0 Td (0,6)Tj 4.252 0 Td (0,3)Tj /T1_2 1 Tf -24.565 -1.433 Td (Parabacteroides)Tj /T1_1 1 Tf 11.809 0 Td (1,4)Tj 4.252 0 Td (1,2)Tj 4.252 0 Td (0,6)Tj 4.252 0 Td (0,3)Tj /T1_2 1 Tf -24.565 -1.433 Td (Porphyromonas)Tj /T1_1 1 Tf 11.809 0 Td (0,0)Tj 4.252 0 Td (2,4)Tj 4.252 0 Td (0,0)Tj 4.252 0 Td (0,0)Tj /T1_2 1 Tf -24.565 -1.433 Td (Prevotellaceae)Tj /T1_1 1 Tf 11.809 0 Td (5,4)Tj 4.252 0 Td (0,8)Tj 4.252 0 Td (0,8)Tj 4.252 0 Td (0,2)Tj /T1_2 1 Tf -24.565 -1.433 Td (Prevotella)Tj /T1_1 1 Tf 11.809 0 Td (5,4)Tj 4.252 0 Td (0,8)Tj 4.252 0 Td (0,8)Tj 4.252 0 Td (0,2)Tj /T1_2 1 Tf -24.565 -1.433 Td (Rikenellaceae)Tj /T1_1 1 Tf 11.809 0 Td (1,2)Tj 4.252 0 Td (1,0)Tj 4.252 0 Td (0,2)Tj 4.252 0 Td (1,2)Tj /T1_2 1 Tf -24.565 -1.433 Td ([Odoribacteraceae])Tj /T1_1 1 Tf 11.809 0 Td (0,2)Tj 4.252 0 Td (1,3)Tj 4.252 0 Td (0,2)Tj 4.252 0 Td (0,0)Tj /T1_2 1 Tf -24.565 -1.433 Td ([Paraprevotellaceae])Tj /T1_1 1 Tf 11.809 0 Td (0,3)Tj 4.252 0 Td (0,0)Tj 4.252 0 Td (1,0)Tj 4.252 0 Td (0,0)Tj /T1_2 1 Tf -24.565 -1.433 Td (Firmicutes)Tj /T1_1 1 Tf 11.559 0 Td (69,3)Tj 4.252 0 Td (55,5)Tj 4.252 0 Td (48,9)Tj 4.252 0 Td (37,6)Tj /T1_2 1 Tf -24.315 -1.433 Td (Gemellales)Tj /T1_1 1 Tf 11.809 0 Td (0,0)Tj 4.252 0 Td (3,4)Tj 4.252 0 Td (0,3)Tj 4.252 0 Td (0,0)Tj /T1_2 1 Tf -24.565 -1.433 Td (Gemellaceae)Tj /T1_1 1 Tf 11.809 0 Td (0,0)Tj 4.252 0 Td (3,4)Tj 4.252 0 Td (0,3)Tj 4.252 0 Td (0,0)Tj /T1_2 1 Tf -24.565 -1.433 Td (Lactobacillales)Tj /T1_1 1 Tf 11.809 0 Td (2,5)Tj 4.252 0 Td (0,6)Tj 4.252 0 Td (0,0)Tj 4.252 0 Td (0,4)Tj /T1_2 1 Tf -24.565 -1.433 Td (Streptococcaceae)Tj /T1_1 1 Tf 11.809 0 Td (1,6)Tj 4.252 0 Td (0,0)Tj 4.252 0 Td (0,0)Tj 4.252 0 Td (0,4)Tj /T1_2 1 Tf -24.565 -1.433 Td (Streptococcus)Tj /T1_1 1 Tf 11.809 0 Td (1,4)Tj 4.252 0 Td (0,0)Tj 4.252 0 Td (0,0)Tj 4.252 0 Td (0,4)Tj /T1_2 1 Tf -24.565 -1.433 Td (Clostridiales)Tj /T1_1 1 Tf 11.559 0 Td (66,3)Tj 4.252 0 Td (50,8)Tj 4.252 0 Td (46,2)Tj 4.252 0 Td (34,9)Tj /T1_2 1 Tf -24.315 -1.433 Td (Christensenellaceae)Tj /T1_1 1 Tf 11.809 0 Td (1,0)Tj 4.252 0 Td (1,4)Tj 4.252 0 Td (3,0)Tj 4.252 0 Td (0,0)Tj /T1_2 1 Tf -24.565 -1.433 Td (Clostridiaceae)Tj /T1_1 1 Tf 11.809 0 Td (2,4)Tj 4.252 0 Td (0,1)Tj 4.252 0 Td (0,4)Tj 4.252 0 Td (0,8)Tj /T1_2 1 Tf -24.565 -1.433 Td (Lachnospiraceae)Tj /T1_1 1 Tf 11.559 0 Td (27,4)Tj 4.502 0 Td (8,5)Tj 4.002 0 Td (10,5)Tj 4.252 0 Td (17,4)Tj /T1_2 1 Tf -24.315 -1.433 Td (Blautia)Tj /T1_1 1 Tf 11.809 0 Td (6,9)Tj 4.252 0 Td (0,0)Tj 4.252 0 Td (0,3)Tj 4.252 0 Td (8,3)Tj /T1_2 1 Tf -24.565 -1.433 Td (Coprococcus)Tj /T1_1 1 Tf 11.809 0 Td (4,8)Tj 4.252 0 Td (1,3)Tj 4.252 0 Td (1,7)Tj 4.252 0 Td (0,8)Tj /T1_2 1 Tf -24.565 -1.433 Td (Dorea)Tj /T1_1 1 Tf 11.809 0 Td (1,3)Tj 4.252 0 Td (0,1)Tj 4.252 0 Td (0,5)Tj 4.252 0 Td (3,0)Tj /T1_2 1 Tf -24.565 -1.433 Td (Roseburia)Tj /T1_1 1 Tf 11.809 0 Td (4,7)Tj 4.252 0 Td (0,0)Tj 4.252 0 Td (0,0)Tj 4.252 0 Td (0,8)Tj /T1_2 1 Tf -24.565 -1.433 Td ([Ruminococcus])Tj /T1_1 1 Tf 11.809 0 Td (1,0)Tj 4.252 0 Td (2,8)Tj 4.252 0 Td (3,0)Tj 4.252 0 Td (2,2)Tj /T1_2 1 Tf -24.565 -1.433 Td (Peptostreptococcaceae)Tj /T1_1 1 Tf 11.809 0 Td (0,0)Tj 4.252 0 Td (4,3)Tj 4.252 0 Td (0,6)Tj 4.252 0 Td (0,0)Tj /T1_2 1 Tf -24.565 -1.433 Td (Peptostreptococcus)Tj /T1_1 1 Tf 11.809 0 Td (0,0)Tj 4.252 0 Td (4,3)Tj 4.252 0 Td (0,6)Tj 4.252 0 Td (0,0)Tj /T1_2 1 Tf -24.565 -1.433 Td (Ruminococcaceae)Tj /T1_1 1 Tf 11.559 0 Td (25,2)Tj 4.502 0 Td (8,8)Tj 4.002 0 Td (25,5)Tj 4.252 0 Td (12,7)Tj ET /GS2 gs q 1 0 0 1 274.9606 712.3464 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 275.2106 700.8771 cm 0 0 m 0 11.219 l S Q q 1 0 0 1 360.25 712.3464 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 360.25 701.1271 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 394.2657 712.3464 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 428.2815 712.3464 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 462.2972 712.3464 cm 0 0 m 34.266 0 l S Q q 1 0 0 1 496.313 701.1271 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 275.2106 680.0579 cm 0 0 m 0 20.819 l S Q q 1 0 0 1 360 700.8771 cm 0 0 m 34.266 0 l S Q q 1 0 0 1 360.25 680.0579 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 394.2657 700.8771 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 394.2657 680.0579 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 428.2815 700.8771 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 428.2815 680.0579 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 462.2972 700.8771 cm 0 0 m 34.266 0 l S Q q 1 0 0 1 462.2972 680.0579 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 496.313 680.0579 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 274.9606 679.8079 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 275.2106 668.5967 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 360.25 679.8079 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 360.25 668.5967 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 394.2657 679.8079 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 394.2657 668.5967 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 428.2815 679.8079 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 428.2815 668.5967 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 462.2972 679.8079 cm 0 0 m 34.266 0 l S Q q 1 0 0 1 462.2972 668.5967 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 668.5967 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 274.9606 668.3467 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 275.2106 657.1354 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 360.25 668.3467 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 360.25 657.1354 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 394.2657 668.3467 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 394.2657 657.1354 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 428.2815 668.3467 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 428.2815 657.1354 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 462.2972 668.3467 cm 0 0 m 34.266 0 l S Q q 1 0 0 1 462.2972 657.1354 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 657.1354 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 274.9606 656.8854 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 275.2106 645.6741 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 360.25 656.8854 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 360.25 645.6741 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 394.2657 656.8854 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 394.2657 645.6741 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 428.2815 656.8854 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 428.2815 645.6741 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 462.2972 656.8854 cm 0 0 m 34.266 0 l S Q q 1 0 0 1 462.2972 645.6741 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 645.6741 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 274.9606 645.4241 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 275.2106 634.2128 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 360.25 645.4241 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 360.25 634.2128 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 394.2657 645.4241 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 394.2657 634.2128 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 428.2815 645.4241 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 428.2815 634.2128 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 462.2972 645.4241 cm 0 0 m 34.266 0 l S Q q 1 0 0 1 462.2972 634.2128 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 634.2128 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 274.9606 633.9628 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 275.2106 622.7515 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 360.25 633.9628 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 360.25 622.7515 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 394.2657 633.9628 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 394.2657 622.7515 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 428.2815 633.9628 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 428.2815 622.7515 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 462.2972 633.9628 cm 0 0 m 34.266 0 l S Q q 1 0 0 1 462.2972 622.7515 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 622.7515 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 274.9606 622.5015 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 275.2106 611.2902 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 360.25 622.5015 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 360.25 611.2902 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 394.2657 622.5015 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 394.2657 611.2902 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 428.2815 622.5015 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 428.2815 611.2902 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 462.2972 622.5015 cm 0 0 m 34.266 0 l S Q q 1 0 0 1 462.2972 611.2902 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 611.2902 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 274.9606 611.0402 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 275.2106 599.829 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 360.25 611.0402 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 360.25 599.829 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 394.2657 611.0402 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 394.2657 599.829 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 428.2815 611.0402 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 428.2815 599.829 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 462.2972 611.0402 cm 0 0 m 34.266 0 l S Q q 1 0 0 1 462.2972 599.829 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 599.829 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 274.9606 599.579 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 275.2106 588.3677 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 360.25 599.579 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 360.25 588.3677 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 394.2657 599.579 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 394.2657 588.3677 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 428.2815 599.579 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 428.2815 588.3677 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 462.2972 599.579 cm 0 0 m 34.266 0 l S Q q 1 0 0 1 462.2972 588.3677 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 588.3677 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 274.9606 588.1177 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 275.2106 576.9064 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 360.25 588.1177 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 360.25 576.9064 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 394.2657 588.1177 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 394.2657 576.9064 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 428.2815 588.1177 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 428.2815 576.9064 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 462.2972 588.1177 cm 0 0 m 34.266 0 l S Q q 1 0 0 1 462.2972 576.9064 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 576.9064 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 274.9606 576.6564 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 275.2106 565.4451 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 360.25 576.6564 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 360.25 565.4451 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 394.2657 576.6564 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 394.2657 565.4451 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 428.2815 576.6564 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 428.2815 565.4451 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 462.2972 576.6564 cm 0 0 m 34.266 0 l S Q q 1 0 0 1 462.2972 565.4451 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 565.4451 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 274.9606 565.1951 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 275.2106 553.9838 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 360.25 565.1951 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 360.25 553.9838 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 394.2657 565.1951 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 394.2657 553.9838 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 428.2815 565.1951 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 428.2815 553.9838 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 462.2972 565.1951 cm 0 0 m 34.266 0 l S Q q 1 0 0 1 462.2972 553.9838 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 553.9838 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 274.9606 553.7338 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 275.2106 542.5225 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 360.25 553.7338 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 360.25 542.5225 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 394.2657 553.7338 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 394.2657 542.5225 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 428.2815 553.7338 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 428.2815 542.5225 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 462.2972 553.7338 cm 0 0 m 34.266 0 l S Q q 1 0 0 1 462.2972 542.5225 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 542.5225 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 274.9606 542.2725 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 275.2106 531.0613 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 360.25 542.2725 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 360.25 531.0613 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 394.2657 542.2725 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 394.2657 531.0613 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 428.2815 542.2725 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 428.2815 531.0613 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 462.2972 542.2725 cm 0 0 m 34.266 0 l S Q q 1 0 0 1 462.2972 531.0613 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 531.0613 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 274.9606 530.8113 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 275.2106 519.6 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 360.25 530.8113 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 360.25 519.6 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 394.2657 530.8113 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 394.2657 519.6 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 428.2815 530.8113 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 428.2815 519.6 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 462.2972 530.8113 cm 0 0 m 34.266 0 l S Q q 1 0 0 1 462.2972 519.6 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 519.6 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 274.9606 519.35 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 275.2106 508.1387 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 360.25 519.35 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 360.25 508.1387 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 394.2657 519.35 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 394.2657 508.1387 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 428.2815 519.35 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 428.2815 508.1387 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 462.2972 519.35 cm 0 0 m 34.266 0 l S Q q 1 0 0 1 462.2972 508.1387 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 508.1387 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 274.9606 507.8887 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 275.2106 496.6774 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 360.25 507.8887 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 360.25 496.6774 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 394.2657 507.8887 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 394.2657 496.6774 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 428.2815 507.8887 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 428.2815 496.6774 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 462.2972 507.8887 cm 0 0 m 34.266 0 l S Q q 1 0 0 1 462.2972 496.6774 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 496.6774 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 274.9606 496.4274 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 275.2106 485.2161 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 360.25 496.4274 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 360.25 485.2161 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 394.2657 496.4274 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 394.2657 485.2161 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 428.2815 496.4274 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 428.2815 485.2161 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 462.2972 496.4274 cm 0 0 m 34.266 0 l S Q q 1 0 0 1 462.2972 485.2161 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 485.2161 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 274.9606 484.9661 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 275.2106 473.7548 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 360.25 484.9661 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 360.25 473.7548 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 394.2657 484.9661 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 394.2657 473.7548 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 428.2815 484.9661 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 428.2815 473.7548 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 462.2972 484.9661 cm 0 0 m 34.266 0 l S Q q 1 0 0 1 462.2972 473.7548 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 473.7548 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 274.9606 473.5048 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 275.2106 462.2935 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 360.25 473.5048 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 360.25 462.2935 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 394.2657 473.5048 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 394.2657 462.2935 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 428.2815 473.5048 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 428.2815 462.2935 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 462.2972 473.5048 cm 0 0 m 34.266 0 l S Q q 1 0 0 1 462.2972 462.2935 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 462.2935 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 274.9606 462.0435 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 275.2106 450.8323 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 360.25 462.0435 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 360.25 450.8323 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 394.2657 462.0435 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 394.2657 450.8323 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 428.2815 462.0435 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 428.2815 450.8323 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 462.2972 462.0435 cm 0 0 m 34.266 0 l S Q q 1 0 0 1 462.2972 450.8323 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 450.8323 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 274.9606 450.5823 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 275.2106 439.371 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 360.25 450.5823 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 360.25 439.371 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 394.2657 450.5823 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 394.2657 439.371 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 428.2815 450.5823 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 428.2815 439.371 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 462.2972 450.5823 cm 0 0 m 34.266 0 l S Q q 1 0 0 1 462.2972 439.371 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 439.371 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 274.9606 439.121 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 275.2106 427.9097 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 360.25 439.121 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 360.25 427.9097 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 394.2657 439.121 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 394.2657 427.9097 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 428.2815 439.121 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 428.2815 427.9097 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 462.2972 439.121 cm 0 0 m 34.266 0 l S Q q 1 0 0 1 462.2972 427.9097 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 427.9097 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 274.9606 427.6597 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 275.2106 416.4484 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 360.25 427.6597 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 360.25 416.4484 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 394.2657 427.6597 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 394.2657 416.4484 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 428.2815 427.6597 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 428.2815 416.4484 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 462.2972 427.6597 cm 0 0 m 34.266 0 l S Q q 1 0 0 1 462.2972 416.4484 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 416.4484 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 274.9606 416.1984 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 275.2106 404.9871 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 360.25 416.1984 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 360.25 404.9871 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 394.2657 416.1984 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 394.2657 404.9871 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 428.2815 416.1984 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 428.2815 404.9871 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 462.2972 416.1984 cm 0 0 m 34.266 0 l S Q q 1 0 0 1 462.2972 404.9871 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 404.9871 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 274.9606 404.7371 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 275.2106 393.5258 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 360.25 404.7371 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 360.25 393.5258 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 394.2657 404.7371 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 394.2657 393.5258 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 428.2815 404.7371 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 428.2815 393.5258 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 462.2972 404.7371 cm 0 0 m 34.266 0 l S Q q 1 0 0 1 462.2972 393.5258 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 393.5258 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 274.9606 393.2758 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 275.2106 382.0646 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 360.25 393.2758 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 360.25 382.0646 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 394.2657 393.2758 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 394.2657 382.0646 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 428.2815 393.2758 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 428.2815 382.0646 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 462.2972 393.2758 cm 0 0 m 34.266 0 l S Q q 1 0 0 1 462.2972 382.0646 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 382.0646 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 274.9606 381.8146 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 275.2106 370.6033 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 360.25 381.8146 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 360.25 370.6033 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 394.2657 381.8146 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 394.2657 370.6033 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 428.2815 381.8146 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 428.2815 370.6033 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 462.2972 381.8146 cm 0 0 m 34.266 0 l S Q q 1 0 0 1 462.2972 370.6033 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 370.6033 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 274.9606 370.3533 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 275.2106 359.142 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 360.25 370.3533 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 360.25 359.142 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 394.2657 370.3533 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 394.2657 359.142 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 428.2815 370.3533 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 428.2815 359.142 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 462.2972 370.3533 cm 0 0 m 34.266 0 l S Q q 1 0 0 1 462.2972 359.142 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 359.142 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 274.9606 358.892 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 275.2106 347.6807 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 360.25 358.892 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 360.25 347.6807 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 394.2657 358.892 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 394.2657 347.6807 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 428.2815 358.892 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 428.2815 347.6807 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 462.2972 358.892 cm 0 0 m 34.266 0 l S Q q 1 0 0 1 462.2972 347.6807 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 347.6807 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 274.9606 347.4307 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 275.2106 336.2194 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 360.25 347.4307 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 360.25 336.2194 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 394.2657 347.4307 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 394.2657 336.2194 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 428.2815 347.4307 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 428.2815 336.2194 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 462.2972 347.4307 cm 0 0 m 34.266 0 l S Q q 1 0 0 1 462.2972 336.2194 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 336.2194 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 274.9606 335.9694 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 275.2106 324.7581 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 360.25 335.9694 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 360.25 324.7581 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 394.2657 335.9694 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 394.2657 324.7581 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 428.2815 335.9694 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 428.2815 324.7581 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 462.2972 335.9694 cm 0 0 m 34.266 0 l S Q q 1 0 0 1 462.2972 324.7581 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 324.7581 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 274.9606 324.5081 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 275.2106 313.2969 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 360.25 324.5081 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 360.25 313.2969 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 394.2657 324.5081 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 394.2657 313.2969 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 428.2815 324.5081 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 428.2815 313.2969 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 462.2972 324.5081 cm 0 0 m 34.266 0 l S Q q 1 0 0 1 462.2972 313.2969 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 313.2969 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 274.9606 313.0469 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 275.2106 301.8356 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 360.25 313.0469 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 360.25 301.8356 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 394.2657 313.0469 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 394.2657 301.8356 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 428.2815 313.0469 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 428.2815 301.8356 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 462.2972 313.0469 cm 0 0 m 34.266 0 l S Q q 1 0 0 1 462.2972 301.8356 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 301.8356 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 274.9606 301.5856 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 360.25 301.5856 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 394.2657 301.5856 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 428.2815 301.5856 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 462.2972 301.5856 cm 0 0 m 34.266 0 l S Q BT /GS1 gs /T1_3 1 Tf 8 0 0 8 303.1825 693.1771 Tm (\020\004\220\217\002\b\013)Tj 8.906 1.317 Td (\017\003\b\002\217\t\003\r\f\001\b\002\r \217\002\240\r\006\202\004\b\t\r\ , %)Tj 0.075 -1.434 Td (1)Tj -0.829 -1.2 Td (\021, 52)Tj 5.081 1.2 Td (2)Tj -0.779 -1.2 Td (\027, 52)Tj 5.031 1.2 Td (3)Tj -0.833 -1.2 Td (\225, 68)Tj 5.085 1.2 Td (4)Tj -0.975 -1.2 Td (\016, 68)Tj /T1_2 1 Tf -23.904 -1.433 Td (Faecalibacterium)Tj /T1_1 1 Tf 11.809 0 Td (9,1)Tj 4.252 0 Td (0,0)Tj 4.252 0 Td (0,0)Tj 4.252 0 Td (5,2)Tj /T1_2 1 Tf -24.565 -1.433 Td (Oscillospira)Tj /T1_1 1 Tf 11.809 0 Td (0,9)Tj 4.252 0 Td (2,3)Tj 4.252 0 Td (1,4)Tj 4.252 0 Td (1,6)Tj /T1_2 1 Tf -24.565 -1.433 Td (Ruminococcus)Tj /T1_1 1 Tf 11.809 0 Td (3,0)Tj 4.252 0 Td (0,3)Tj 4.002 0 Td (10,7)Tj 4.502 0 Td (2,3)Tj /T1_2 1 Tf -24.565 -1.433 Td (Veillonellaceae)Tj /T1_1 1 Tf 11.809 0 Td (1,0)Tj 4.252 0 Td (0,1)Tj 4.252 0 Td (2,3)Tj 4.252 0 Td (2,2)Tj /T1_2 1 Tf -24.565 -1.433 Td (Dialister)Tj /T1_1 1 Tf 11.809 0 Td (0,3)Tj 4.252 0 Td (0,0)Tj 4.252 0 Td (0,1)Tj 4.252 0 Td (1,5)Tj /T1_2 1 Tf -24.565 -1.433 Td (Phascolarctobacterium)Tj /T1_1 1 Tf 11.809 0 Td (0,7)Tj 4.252 0 Td (0,0)Tj 4.252 0 Td (2,3)Tj 4.252 0 Td (0,0)Tj /T1_2 1 Tf -24.565 -1.433 Td ([Mogibacteriaceae])Tj /T1_1 1 Tf 11.809 0 Td (0,3)Tj 4.252 0 Td (1,1)Tj 4.252 0 Td (0,2)Tj 4.252 0 Td (0,0)Tj /T1_2 1 Tf -24.565 -1.433 Td ([Tissierellaceae])Tj /T1_1 1 Tf 11.809 0 Td (0,0)Tj 4.002 0 Td (23,1)Tj 4.502 0 Td (1,4)Tj 4.252 0 Td (0,0)Tj /T1_2 1 Tf -24.565 -1.433 Td (Anaerococcus)Tj /T1_1 1 Tf 11.809 0 Td (0,0)Tj 4.252 0 Td (2,1)Tj 4.252 0 Td (0,0)Tj 4.252 0 Td (0,0)Tj /T1_2 1 Tf -24.565 -1.433 Td (Parvimonas)Tj /T1_1 1 Tf 11.809 0 Td (0,0)Tj 4.002 0 Td (21,0)Tj 4.502 0 Td (1,4)Tj 4.252 0 Td (0,0)Tj /T1_2 1 Tf -24.565 -1.433 Td (Erysipelotrichales)Tj /T1_1 1 Tf 11.809 0 Td (0,4)Tj 4.252 0 Td (0,2)Tj 4.252 0 Td (2,3)Tj 4.252 0 Td (2,2)Tj /T1_2 1 Tf -24.565 -1.433 Td (Erysipelotrichaceae)Tj /T1_1 1 Tf 11.809 0 Td (0,0)Tj 4.252 0 Td (0,3)Tj 4.252 0 Td (2,3)Tj 4.252 0 Td (2,4)Tj /T1_2 1 Tf -24.565 -1.433 Td (Proteobacteria)Tj /T1_1 1 Tf 11.809 0 Td (9,5)Tj 4.002 0 Td (17,5)Tj 4.502 0 Td (4,5)Tj 4.252 0 Td (8,0)Tj /T1_2 1 Tf -24.565 -1.433 Td (Rhizobiales)Tj /T1_1 1 Tf 11.809 0 Td (0,6)Tj 4.252 0 Td (0,4)Tj 4.252 0 Td (0,2)Tj 4.252 0 Td (1,3)Tj /T1_2 1 Tf -24.565 -1.433 Td (Burkholderiales)Tj /T1_1 1 Tf 11.809 0 Td (1,3)Tj 4.252 0 Td (0,1)Tj 4.252 0 Td (0,1)Tj 4.252 0 Td (2,0)Tj /T1_2 1 Tf -24.565 -1.433 Td (Alcaligenaceae)Tj /T1_1 1 Tf 11.809 0 Td (0,2)Tj 4.252 0 Td (0,0)Tj 4.252 0 Td (0,1)Tj 4.252 0 Td (1,8)Tj /T1_2 1 Tf -24.565 -1.433 Td (Sutterella)Tj /T1_1 1 Tf 11.809 0 Td (0,2)Tj 4.252 0 Td (0,0)Tj 4.252 0 Td (0,1)Tj 4.252 0 Td (1,8)Tj /T1_2 1 Tf -24.565 -1.433 Td (Oxalobacteraceae)Tj /T1_1 1 Tf 11.809 0 Td (1,0)Tj 4.252 0 Td (0,0)Tj 4.252 0 Td (0,1)Tj 4.252 0 Td (0,2)Tj /T1_2 1 Tf -24.565 -1.433 Td (Ralstonia)Tj /T1_1 1 Tf 11.809 0 Td (1,0)Tj 4.252 0 Td (0,0)Tj 4.252 0 Td (0,0)Tj 4.252 0 Td (0,2)Tj /T1_2 1 Tf -24.565 -1.433 Td (Desulfovibrionales)Tj /T1_1 1 Tf 11.809 0 Td (0,0)Tj 4.252 0 Td (2,2)Tj 4.252 0 Td (0,3)Tj 4.252 0 Td (0,0)Tj /T1_2 1 Tf -24.565 -1.433 Td (Desulfovibrionaceae)Tj /T1_1 1 Tf 11.809 0 Td (0,0)Tj 4.252 0 Td (2,2)Tj 4.252 0 Td (0,3)Tj 4.252 0 Td (0,0)Tj /T1_2 1 Tf -24.565 -1.433 Td (Desulfovibrio)Tj /T1_1 1 Tf 11.809 0 Td (0,0)Tj 4.252 0 Td (1,2)Tj 4.252 0 Td (0,0)Tj 4.252 0 Td (0,0)Tj /T1_2 1 Tf -24.565 -1.433 Td (Enterobacteriales)Tj /T1_1 1 Tf 11.809 0 Td (5,4)Tj 4.002 0 Td (14,6)Tj 4.502 0 Td (3,8)Tj 4.252 0 Td (4,5)Tj /T1_2 1 Tf -24.565 -1.433 Td (Enterobacteriaceae)Tj /T1_1 1 Tf 11.809 0 Td (5,4)Tj 4.002 0 Td (14,6)Tj 4.502 0 Td (3,8)Tj 4.252 0 Td (4,5)Tj /T1_2 1 Tf -24.565 -1.433 Td (Pseudomonadales)Tj /T1_1 1 Tf 11.809 0 Td (1,4)Tj 4.252 0 Td (0,1)Tj 4.252 0 Td (0,0)Tj 4.252 0 Td (0,0)Tj /T1_2 1 Tf -24.565 -1.433 Td (Synergistetes)Tj /T1_1 1 Tf 11.809 0 Td (0,0)Tj 4.252 0 Td (0,0)Tj 4.252 0 Td (1,5)Tj 4.252 0 Td (0,2)Tj /T1_2 1 Tf -24.565 -1.433 Td (Synergistales)Tj /T1_1 1 Tf 11.809 0 Td (0,0)Tj 4.252 0 Td (0,0)Tj 4.252 0 Td (1,5)Tj 4.252 0 Td (0,2)Tj /T1_2 1 Tf -24.565 -1.433 Td (Synergistaceae)Tj /T1_1 1 Tf 11.809 0 Td (0,0)Tj 4.252 0 Td (0,0)Tj 4.252 0 Td (1,5)Tj 4.252 0 Td (0,0)Tj /T1_2 1 Tf -24.565 -1.433 Td (Verrucomicrobia)Tj /T1_1 1 Tf 11.809 0 Td (0,4)Tj 4.252 0 Td (8,3)Tj 4.002 0 Td (30,6)Tj 4.502 0 Td (0,0)Tj /T1_2 1 Tf -24.565 -1.433 Td (Verrucomicrobiales)Tj /T1_1 1 Tf 11.809 0 Td (0,4)Tj 4.252 0 Td (8,2)Tj 4.002 0 Td (30,6)Tj 4.502 0 Td (0,0)Tj /T1_2 1 Tf -24.565 -1.433 Td (Verrucomicrobiaceae)Tj /T1_1 1 Tf 11.809 0 Td (0,4)Tj 4.252 0 Td (8,2)Tj 4.002 0 Td (30,6)Tj 4.502 0 Td (0,0)Tj /T1_2 1 Tf -24.565 -1.433 Td (Akkermansia)Tj /T1_1 1 Tf 11.809 0 Td (0,4)Tj 4.252 0 Td (8,2)Tj 4.002 0 Td (30,6)Tj 4.502 0 Td (0,0)Tj -24.565 -1.433 Td (\212\030\031\020\017\036 \235\017\035\t)Tj 11.809 0 Td (0,6)Tj 4.252 0 Td (0,3)Tj 4.252 0 Td (0,7)Tj 4.252 0 Td (0,0)Tj /T1_2 1 Tf 7 0 0 7 274.9606 290.1009 Tm (\032\025\003\031\006\026\021\025\031: * \032\031\030\t\024\026\027\023\ \031\021\020 \024\026\013\t\n\021\020, \n\024\021\n\t\025\024\031\023\022\ \021\n\031 \t\n\030\031\032\204\026\021\025\031 )Tj T* (\013\n\024\n\032\020\004 \033\n)Tj /Span<>> BDC ( )Tj EMC (\013\032\026\017\021\031\017 \003\031\032\031 \027)Tj /Span<>> BDC ( )Tj EMC (\n\030\021\n\003 \025\016)Tj /Span<>> BDC ( )Tj EMC (\n\005\032\026\016\203\n\027 \033\032\031\027\020\001\026\031\024 1%)Tj T* [(N)17(o)13(te: * The tax)10.1(a with av)13.1(erag)12(e relativ)13.1(e abund)26(ance abov)13.1(e 1% at least in one of the )]TJ T* [(sam)16(ples are displayed)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\033\030\031\030\213\b)-20.9(\035\231\213\233\t \021\032)50(\b)42(\032\231\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj /T1_4 1 Tf 25 0 0 25 503.8146 56.0378 Tm (111)Tj ET endstream endobj 1169 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1170 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1171 0 obj <>/ExtGState<>/Font<>/ProcSet[/PDF/Text]/Properties<>/Shading<>/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1172 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1173 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1389 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.061 Tw 10 0 0 10 70.8661 335.1339 Tm (26.04.2022 \023\030\024\021\024\022\024\035 \2254, \024\021 \022\026\032\ \007\024\020\024 \023\026\006\017\036\027\021\026 \023\024\035\031)Tj 0 Tw (-)Tj 0 -1.218 TD (\004\036\027\024 \017\027\235\024\030\n\017\030\024\r\026\027\027\024\036\ \f\024\020\035\026\f\017\036.)Tj 0.08 Tw T* (\200 \b\024\007\036 \024\023\036\030\026\021\017\r\027\024\020\024 \r\n\036\ \001\026\021\036\035\034\f\021\r\026 \023\024\f\035\036 \030\036\036\022\ \006\017\017 )Tj 0.276 Tw T* (\022\017\001\022\017 \r)Tj /Span<>> BDC ( )Tj EMC 4.119 0 Td [(\f\021\036\030\017\035\034\027\t\b )0.5(\031\f\035\024\r\017\016\b )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC [(\023\030\036\023\026\030\026\021\026 )0.5(\030\036\036)]TJ 0 Tw (-)Tj 0.295 Tw -4.119 -1.218 Td (\006\017\030\024\r\026\027\027\024\005 \022\017\001\022\017 \023\030\024\ \r\024\007\017\035\017 \026\002\024\030 \023\024\030\026\032\036\027\027\ \024\020\024 )Tj 0.248 Tw T* (\007\017\r\036\030\021\017\022\031\035\026 \r)Tj /Span<>> BDC ( )Tj EMC (\036\007\017\027\024\n \002\035\024\022\036 \f)Tj /Span<>> BDC ( )Tj EMC (\024\022\030\031\032\026\033\013\017\n\017 \021\022\026)Tj 0 Tw (-)Tj 0.178 Tw T* (\027\016\n\017, \027\036 \030\026\030\031\001\026\016 \036\020\024 \006\ \036\035\024\f\021\027\024\f\021\017, \026\021\036\n \024\002\030\026\006\ \t )Tj 0.392 Tw T* [(\024\021\023\030\026\r\035\016\035\017 )0.6(\027\026)]TJ /Span<>> BDC ( )Tj EMC 6.983 0 Td [(\n\017\022\030\024\002\017\024\035\024\020\017\004\036\f\022\024\036 )0.6(\017\f\f\035\036\007\024\r\026\027\017\036 )]TJ 0.074 Tw -6.983 -1.218 Td (\017)Tj /Span<>> BDC ( )Tj EMC [(\020\036\027\024\n\027\024\036 )0.5(\f\036\022\r\036\027\017\030\024\r\026\027\017\036 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC [(\205\206\202\210\211 )0.5(\200\210 \253\025\026\026\027\f\022\017\005 )]TJ 1.874 Tw T* (\(\215\030\017\r\024\035\032\f\022\017\005\) \235\036\007\036\030\026\035\ \034\027\t\005 \031\027\017\r\036\030\f\017\021\036\021\273. )Tj 0.109 Tw T* [(\230\030\026\027\f\023\024\030\021\017\030\024\r\022\031 \024\002\030\026\ \006\024\r )0.5(\023\030\024\r\024\007\017\035\017 \023\030\017)]TJ /Span<>> BDC ( )Tj EMC (\021\036\n\023\036\030\026)Tj 0 Tw (-)Tj T* (\021\031\030\036)Tj /Span<>> BDC ( )Tj EMC (+)Tj /Span<>> BDC ( )Tj EMC (4\260\221 \023\030\024\007\024\035\032\017\021\036\035\034\027\024\f\021\ \034\033 \027\036 \002\024\035\036\036 2 \004\026\f\024\r.)Tj 0.203 Tw T* (\221\023\036\022\021\030 \022\031\035\034\021\017\r\017\030\031\036\n\t\b\ \n\017\022\030\024\024\030\020\026\027\017\n\024\r \024\002\030\026\006\ \024\r )Tj 0.356 Tw T* (\026\027\026\035\017\017\030\024\r\026\035\017 \n\036\021\024\007\026\n\ \017 \022\035\026\f\f\017\004\036\f\022\024\005 \n\017\022\030\024\002\017\ \024)Tj 0 Tw (-)Tj 0.242 Tw T* (\035\024\020\017\017 \f)Tj /Span<>> BDC ( )Tj EMC (\017\f\023\024\035\034\024\r\026\027\017\036\n \023\017\021\026\021\036\ \035\034\027\t\b \f\030\036\007 \024\002\013\036\020\024 )Tj 0.036 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\f\023\036\006\017\026\035\034\027\024\020\024 \027\026\027\026\004\036\ \027\017\016, \022\026\022 \024\023\017\f\026\027\024 \027\026\n\017 \030\ \026\027\036\036 )Tj 0.2 Tw T* ([9]. \210\002\030\026\006\t \023\030\036\007\r\026\030\017\021\036\035\034\ \027\024 \024\002\030\026\002\026\021\t\r\026\035\017 \023\030\024\021\036\ )Tj 0 Tw (-)Tj 0.128 Tw T* (\017\027\026\024\005 \r)Tj /Span<>> BDC ( )Tj EMC (\021\036\004\036\027\017\036 1 \004\026\f\026 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (55)Tj /Span<>> BDC ( )Tj EMC 13.834 0 Td (\260C, \023\024\f\035\036 \004\036\020\024 \023\030\024)Tj 0 Tw (-)Tj 0.1 Tw -13.834 -1.218 Td (\r\024\007\017\035\017 \r\t\007\036\035\036\027\017\036 \212\203\025 \f)Tj /Span<>> BDC ( )Tj EMC [(\023\024\n\024\013\034\033 \027\026\002\024\030\026 F)20(ast DN)13(A )]TJ 0.037 Tw T* [(SPIN Ki)-23.9(t \(MP Biomedicals\). \215\024\007\020\024\021\024\r\022\031 \n\036\021\026\ \020\036\027\024\n\027\t\b )]TJ 0.311 Tw T* [(\002\017\002\035\017\024\021\036\022 \212\203\025 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC [(\r\t\f\024\022\024\023\030\024\017\r\024\007\017\021\036\035\034\027\024\ \036 )0.6(\f\036\022\r\036)]TJ 0 Tw (-)Tj 0.327 Tw T* (\027\017\030\024\r\026\027\017\036 \023\030\024\r\024\007\017\035\017 \023\ \024)Tj /Span<>> BDC ( )Tj EMC (\f\021\026\027\007\026\030\021\027\024\n\031 \023\030\024\021\024\022\024\ \035\031 )Tj 0.354 Tw 23.244 25.574 Td (\023\030\024\017\r\024\007\017\021\036\035\016 \027\026)Tj /Span<>> BDC ( )Tj EMC [(\023\030\017\002\024\030\036 MiSeq \(Ill)35(umina, \221\234\202\) )]TJ 0.014 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\017\f\023\024\035\034\024\r\026\027\017\036\n \023\026\030\t \023\030\026\ \005\n\036\030\024\r, \024\002\036\f\023\036\004\017\r\026\033\013\017\b\ )Tj 0.045 Tw T* (\026\n\023\035\017\235\017\022\026\006\017\033 \020\017\023\036\030\r\026\ \030\017\026\002\036\035\034\027\t\b \031\004\026\f\021\022\024\r V3 \017\ )Tj /Span<>> BDC ( )Tj EMC (V4 )Tj 0.282 Tw T* (16S \030\217\203\025. \217\036\031\035\034\021\026\021\t \f\036\022\r\036\ \027\017\030\024\r\026\027\017\016 \026\027\026\035\017\017\030\024)Tj 0 Tw (-)Tj 0.217 Tw T* (\r\026\035\017 \f)Tj /Span<>> BDC ( )Tj EMC (\023\024\n\024\013\034\033 \023\030\024\020\030\026\n\n\027\024\020\024 \ \024\002\036\f\023\036\004\036\027\017\016 QIIME )Tj 0.097 Tw T* (1.9.1. \200\t\030\026\r\027\036\027\027\t\036 \023\024\f\035\036\007\024\ \r\026\021\036\035\034\027\024\f\021\017 \f\020\030\031\023\023\017\030\024\ )Tj 0 Tw (-)Tj 0.207 Tw T* (\r\t\r\026\035\017 \r)Tj /Span<>> BDC ( )Tj EMC (\024\023\036\030\026\006\017\024\027\027\t\036 \021\026\022\f\024\027\024\ \n\017\004\036\f\022\017\036 \036\007\017\027\017\006\t )Tj 0 Tw T* (\(\210\230\213\) \f)Tj /Span<>> BDC ( )Tj EMC (97% \f\b\024\007\f\021\r\024\n.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 303.3769 213.3539 Tm [(\033\034\020)21(\223)50(\r\241)46(\024)52(\026)45(\024\232)]TJ 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0 Tc 0.091 Tw 10 0 0 10 303.3071 188.9979 Tm (\221 \006\036\035\034\033 \024\023\030\036\007\036\035\036\027\017\016 \n\ \017\022\030\024\002\017\024\021\t \r\027\031\021\030\017 \r\024\f\023\026\ \035\036\027)Tj 0 Tw (-)Tj 0.194 Tw T* (\027\t\b \007\017\r\036\030\021\017\022\031\035\024\r, \023\030\017\f\021\ \036\027\024\004\027\026\016 \n\017\022\030\024\002\017\024\021\026 \004\ \036\021\t)Tj 0 Tw (-)Tj 0.154 Tw T* (\030\036\b \r\024\f\023\026\035\036\027\027\t\b \007\017\r\036\030\021\017\ \022\031\035\024\r \f\017\020\n\024\r\017\007\027\024\005 \022\017\001\022\ \017 )Tj 0.664 Tw T* [(\017\f\f\035\036\007\024\r\026\027\026 )0.6(\030\031\021\017\027\027\t\n\017 )0.5(\n\036\021\024\007\026\n\017 )0.6(\022\035\026\f\f\017\004\036\f\022\024\005 )]TJ 0.08 Tw T* (\n\017\022\030\024\002\017\024\035\024\020\017\017 \(\230\026\002\035.)Tj /Span<>> BDC ( )Tj EMC (2\) \017)Tj /Span<>> BDC ( )Tj EMC (\f \023\024\n\024\013\034\033 \026\027\026\035\017\026 \002\017\002)Tj 0 Tw (-)Tj 0.089 Tw T* (\035\017\024\021\036\022 \023\024\f\035\036\007\024\r\026\021\036\035\034\ \027\024\f\021\036\005 \020\036\027\024\r 16S \030\217\203\025, \f\036\022\ \r\036)Tj 0 Tw (-)Tj 0.005 Tw T* [(\027\017\030\024\r\026\027\027\t\b )0.5(\027\026)]TJ /Span<>> BDC ( )Tj EMC [(\023\035\026\021\235\024\030\n\036 )0.5(Ill)35(umina )0.5(MiSeq \(\230\026\002\035.)]TJ /Span<>> BDC ( )Tj EMC 20.259 0 Td (3,4\). )Tj 0.113 Tw -20.259 -1.218 Td [(\212\035\016 )0.5(\024\006\036\027\022\017 )0.5(\026\035\034\235\026-\030\026\027\024\024\002\030\026\017\016 )0.5(\(\021\026\022\f\024\027\024\n\017\004\036\f\022\024\020\024 )]TJ 0.09 Tw T* (\002\024\020\026\021\f\021\r\026 \n\017\022\030\024\002\027\t\b \f\024\024\ \002\013\036\f\021\r\) \030\026\f\f\004\017\021\026\035\017 \017\027\007\ \036\022)Tj 0 Tw (-)Tj 0.197 Tw T* [(\f\t \021\026\022\f\024\027\024\n\017\004\036\f\022\024\020\024 )0.5(\030\026\027\024\024\002\030\026\017\016 \223\026\0241, \234\036\027\027\ \024\027\026 )]TJ 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0 Tw 9 0 0 9 70.8661 730.483 Tm (\020\004\206\f\t\204\004 1.)Tj 0 0 0 1 k /GS1 gs /T1_3 1 Tf ( \222\023\025\021\025\006\031\t\013\025\031 \004\026\032\026\013\024\031\ \032\025\t\024\025\013\025 \n\005\t\023\031\030\n\027\026\021\021\n\017 \ \202\032\205\033\033\020 \033\026\203\025\031\021\024\n\027)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0 -1.2 TD [(T)48(able 1)47(.)]TJ 0 0 0 1 k /GS1 gs /T1_3 1 Tf [( Clinical character)-36.8(istics of the e)-14.8(x)10(amined g)14(roup of patients)]TJ ET 0 0 0 1 K 0.5 w /GS2 gs q 1 0 0 1 70.8661 715.181 cm 0 0 m 14.423 0 l S Q q 1 0 0 1 71.1161 694.3618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 85.2894 715.181 cm 0 0 m 39.685 0 l S Q q 1 0 0 1 85.2894 694.3618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 124.9744 715.181 cm 0 0 m 22.677 0 l S Q q 1 0 0 1 124.9744 694.3618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 147.6516 715.181 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 147.6516 694.3618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 204.3445 715.181 cm 0 0 m 223.937 0 l S Q q 1 0 0 1 204.3445 694.3618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 428.2815 715.181 cm 0 0 m 96.628 0 l S Q q 1 0 0 1 428.2815 694.3618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 524.6594 694.3618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 70.8661 694.1118 cm 0 0 m 14.423 0 l S Q q 1 0 0 1 71.1161 673.3005 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 85.2894 694.1118 cm 0 0 m 39.685 0 l S Q q 1 0 0 1 85.2894 673.3005 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 124.9744 694.1118 cm 0 0 m 22.677 0 l S Q q 1 0 0 1 124.9744 673.3005 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 147.6516 694.1118 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 147.6516 673.3005 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 204.3445 694.1118 cm 0 0 m 223.937 0 l S Q q 1 0 0 1 204.3445 673.3005 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 428.2815 694.1118 cm 0 0 m 96.628 0 l S Q q 1 0 0 1 428.2815 673.3005 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 524.6594 673.3005 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 70.8661 673.0505 cm 0 0 m 14.423 0 l S Q q 1 0 0 1 71.1161 642.6392 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 85.2894 673.0505 cm 0 0 m 39.685 0 l S Q q 1 0 0 1 85.2894 642.6392 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 124.9744 673.0505 cm 0 0 m 22.677 0 l S Q q 1 0 0 1 124.9744 642.6392 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 147.6516 673.0505 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 147.6516 642.6392 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 204.3445 673.0505 cm 0 0 m 223.937 0 l S Q q 1 0 0 1 204.3445 642.6392 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 428.2815 673.0505 cm 0 0 m 96.628 0 l S Q q 1 0 0 1 428.2815 642.6392 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 524.6594 642.6392 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 70.8661 642.3892 cm 0 0 m 14.423 0 l S Q q 1 0 0 1 71.1161 621.5779 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 85.2894 642.3892 cm 0 0 m 39.685 0 l S Q q 1 0 0 1 85.2894 621.5779 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 124.9744 642.3892 cm 0 0 m 22.677 0 l S Q q 1 0 0 1 124.9744 621.5779 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 147.6516 642.3892 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 147.6516 621.5779 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 204.3445 642.3892 cm 0 0 m 223.937 0 l S Q q 1 0 0 1 204.3445 621.5779 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 428.2815 642.3892 cm 0 0 m 96.628 0 l S Q q 1 0 0 1 428.2815 621.5779 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 524.6594 621.5779 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 70.8661 621.3279 cm 0 0 m 14.423 0 l S Q q 1 0 0 1 71.1161 600.5167 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 85.2894 621.3279 cm 0 0 m 39.685 0 l S Q q 1 0 0 1 85.2894 600.5167 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 124.9744 621.3279 cm 0 0 m 22.677 0 l S Q q 1 0 0 1 124.9744 600.5167 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 147.6516 621.3279 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 147.6516 600.5167 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 204.3445 621.3279 cm 0 0 m 223.937 0 l S Q q 1 0 0 1 204.3445 600.5167 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 428.2815 621.3279 cm 0 0 m 96.628 0 l S Q q 1 0 0 1 428.2815 600.5167 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 524.6594 600.5167 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 70.8661 600.2667 cm 0 0 m 14.423 0 l S Q q 1 0 0 1 85.2894 600.2667 cm 0 0 m 39.685 0 l S Q q 1 0 0 1 124.9744 600.2667 cm 0 0 m 22.677 0 l S Q q 1 0 0 1 147.6516 600.2667 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 204.3445 600.2667 cm 0 0 m 223.937 0 l S Q q 1 0 0 1 428.2815 600.2667 cm 0 0 m 96.628 0 l S Q BT /GS1 gs /T1_2 1 Tf 8 0 0 8 74.2788 701.7465 Tm (\232)Tj 1.888 0.6 Td (\200\004\204\t\r\b\003, )Tj 0.301 -1.2 Td (\002\213\006\004\217\003)Tj 4.726 0.6 Td (\200\002\f)Tj 2.954 0.6 Td (\035\002\220\004\f\t\213\004\204\t\235 )Tj 0.045 -1.2 Td (\240\t\r\006\003\t\220\210\f\004)Tj 15.589 0.6 Td (\021\f\t\b\t\201\r\217\220\t\005 \240\t\004\n\b\002\213)Tj 20.672 0.6 Td (\021\210\006\217 \004\b\003\t\206\t\002\003\t\220\002-)Tj -0.01 Tw -1.571 -1.2 Td (\003\r\006\004\212\t\t \212\r\006\r\240 \002\212\r\006\004\204\t\r\005)Tj /T1_0 1 Tf 0 Tw -44.646 -1.433 Td (1)Tj 2.761 0 Td (\025., 52)Tj 4.701 0 Td (\204)Tj 2.615 0 Td (\221\017\020\n\024\r\017\007\027\026\016 )Tj 1.393 -1.2 Td (\022\017\001\022\026)Tj 7.568 1.2 Td (\212\207 \f\017\020\n\024\r\017\007\027\024\005 \022\017\001\022\017, \024\ \f\035\024\032\027\036\027\027\026\016 \007\017\r\036\030\021\017\022\031\ \035\017\021\024\n )Tj 5.2 -1.2 Td (\017)Tj /Span<>> BDC ( )Tj EMC (\023\026\030\026\022\024\035\017\004\036\f\022\017\n \026\002\f\006\036\f\ \f\024\n)Tj 25.599 1.2 Td (\007\026)Tj -49.836 -2.633 Td (2)Tj 2.823 0 Td (\206., 52)Tj 4.639 0 Td (\204)Tj 2.615 0 Td (\221\017\020\n\024\r\017\007\027\026\016 )Tj 1.393 -1.2 Td (\022\017\001\022\026)Tj 7.475 1.2 Td (\212\207 \f\017\020\n\024\r\017\007\027\024\005 \022\017\001\022\017, \024\ \f\035\024\032\027\036\027\027\026\016 \007\017\r\036\030\021\017\022\031\ \035\017\021\024\n, )Tj 0.985 -1.2 Td (\r\024\f\023\026\035\017\021\036\035\034\027\t\n \017\027\235\017\035\034\ \021\030\026\021\024\n \017)Tj /Span<>> BDC ( )Tj EMC (\235\024\030\n\017\030\024\r\026\027\017\036\n )Tj 4.799 -1.2 Td (\r\024\f\023\026\035\017\021\036\035\034\027\024\005 \f\021\030\017\022\021\ \031\030\t)Tj 24.907 2.4 Td (\027\036\021)Tj -49.636 -3.833 Td (3)Tj 2.763 0 Td (\207., 68)Tj 4.699 0 Td (\204)Tj 2.615 0 Td (\221\017\020\n\024\r\017\007\027\026\016 )Tj 1.393 -1.2 Td (\022\017\001\022\026)Tj 5.249 1.2 Td (\212\207 \f\017\020\n\024\r\017\007\027\024\005 \022\017\001\022\017, \007\ \017\r\036\030\021\017\022\031\035\017\021, \b\030\024\027\017\004\036\f\ \022\024\036 \027\036\023\030\036\030\t\r\027\024\036 )Tj 3.595 -1.2 Td (\021\036\004\036\027\017\036, \030\036\235\030\026\022\021\036\030\027\024\ \f\021\034 \022)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\r\024\007\017\n\024\005 \021\036\030\026\023\017\017)Tj 29.323 1.2 Td (\027\036\021)Tj -49.636 -2.633 Td (4)Tj 2.633 0 Td (\234., 68)Tj 4.756 0 Td (\240)Tj 2.688 0 Td (\221\017\020\n\024\r\017\007\027\026\016 )Tj 1.393 -1.2 Td (\022\017\001\022\026)Tj 7.568 1.2 Td (\212\207 \f\017\020\n\024\r\017\007\027\024\005 \022\017\001\022\017, \024\ \f\035\024\032\027\036\027\027\026\016 \007\017\r\036\030\021\017\022\031\ \035\017\021\024\n )Tj 1.818 -1.2 Td (\017)Tj /Span<>> BDC ( )Tj EMC (\235\024\030\n\017\030\024\r\026\027\017\036\n \r\024\f\023\026\035\017\021\ \036\035\034\027\024\005 \f\021\030\017\022\021\031\030\t)Tj 28.981 1.2 Td (\007\026)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 9 0 0 9 70.8661 583.5474 Tm (\020\004\206\f\t\204\004 2.)Tj 0 0 0 1 k /GS1 gs /T1_3 1 Tf [( \255\203\031\021\013\026 \003\025\013\032\n\005\025\n\024\020 \030\025\027\ \031\032\024\025\013\205\023\n\027 \013\205\023\022\024\205\032\026\023\022\ \021\020\003 \003\031\024\n\030)0.5(\n\003)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf T* [(T)48(able 2)16(.)]TJ 0 0 0 1 k /GS1 gs /T1_3 1 Tf [( Microbio)13.1(ta of div)13.1(er)-40(ticula assessed by culture method)]TJ ET /GS2 gs q 1 0 0 1 70.8661 568.2454 cm 0 0 m 170.329 0 l S Q q 1 0 0 1 71.1161 547.4262 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 241.1949 568.2454 cm 0 0 m 70.866 0 l S Q q 1 0 0 1 241.1949 547.4262 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 312.061 568.2454 cm 0 0 m 70.866 0 l S Q q 1 0 0 1 312.061 547.4262 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 382.9272 568.2454 cm 0 0 m 70.866 0 l S Q q 1 0 0 1 382.9272 547.4262 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 453.7933 568.2454 cm 0 0 m 71.116 0 l S Q q 1 0 0 1 453.7933 547.4262 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 524.6594 547.4262 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 70.8661 547.1762 cm 0 0 m 170.329 0 l S Q q 1 0 0 1 71.1161 535.9649 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 241.1949 547.1762 cm 0 0 m 70.866 0 l S Q q 1 0 0 1 241.1949 535.9649 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 312.061 547.1762 cm 0 0 m 70.866 0 l S Q q 1 0 0 1 312.061 535.9649 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 382.9272 547.1762 cm 0 0 m 70.866 0 l S Q q 1 0 0 1 382.9272 535.9649 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 453.7933 547.1762 cm 0 0 m 71.116 0 l S Q q 1 0 0 1 453.7933 535.9649 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 535.9649 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 535.7149 cm 0 0 m 170.329 0 l S Q q 1 0 0 1 71.1161 524.5037 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 241.1949 535.7149 cm 0 0 m 70.866 0 l S Q q 1 0 0 1 241.1949 524.5037 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 312.061 535.7149 cm 0 0 m 70.866 0 l S Q q 1 0 0 1 312.061 524.5037 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 382.9272 535.7149 cm 0 0 m 70.866 0 l S Q q 1 0 0 1 382.9272 524.5037 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 453.7933 535.7149 cm 0 0 m 71.116 0 l S Q q 1 0 0 1 453.7933 524.5037 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 524.5037 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 524.2537 cm 0 0 m 170.329 0 l S Q q 1 0 0 1 71.1161 513.0424 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 241.1949 524.2537 cm 0 0 m 70.866 0 l S Q q 1 0 0 1 241.1949 513.0424 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 312.061 524.2537 cm 0 0 m 70.866 0 l S Q q 1 0 0 1 312.061 513.0424 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 382.9272 524.2537 cm 0 0 m 70.866 0 l S Q q 1 0 0 1 382.9272 513.0424 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 453.7933 524.2537 cm 0 0 m 71.116 0 l S Q q 1 0 0 1 453.7933 513.0424 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 513.0424 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 512.7924 cm 0 0 m 170.329 0 l S Q q 1 0 0 1 71.1161 501.5811 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 241.1949 512.7924 cm 0 0 m 70.866 0 l S Q q 1 0 0 1 241.1949 501.5811 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 312.061 512.7924 cm 0 0 m 70.866 0 l S Q q 1 0 0 1 312.061 501.5811 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 382.9272 512.7924 cm 0 0 m 70.866 0 l S Q q 1 0 0 1 382.9272 501.5811 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 453.7933 512.7924 cm 0 0 m 71.116 0 l S Q q 1 0 0 1 453.7933 501.5811 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 501.5811 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 501.3311 cm 0 0 m 170.329 0 l S Q q 1 0 0 1 71.1161 490.1198 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 241.1949 501.3311 cm 0 0 m 70.866 0 l S Q q 1 0 0 1 241.1949 490.1198 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 312.061 501.3311 cm 0 0 m 70.866 0 l S Q q 1 0 0 1 312.061 490.1198 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 382.9272 501.3311 cm 0 0 m 70.866 0 l S Q q 1 0 0 1 382.9272 490.1198 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 453.7933 501.3311 cm 0 0 m 71.116 0 l S Q q 1 0 0 1 453.7933 490.1198 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 490.1198 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 489.8698 cm 0 0 m 170.329 0 l S Q q 1 0 0 1 71.1161 478.6585 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 241.1949 489.8698 cm 0 0 m 70.866 0 l S Q q 1 0 0 1 241.1949 478.6585 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 312.061 489.8698 cm 0 0 m 70.866 0 l S Q q 1 0 0 1 312.061 478.6585 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 382.9272 489.8698 cm 0 0 m 70.866 0 l S Q q 1 0 0 1 382.9272 478.6585 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 453.7933 489.8698 cm 0 0 m 71.116 0 l S Q q 1 0 0 1 453.7933 478.6585 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 478.6585 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 478.4085 cm 0 0 m 170.329 0 l S Q q 1 0 0 1 241.1949 478.4085 cm 0 0 m 70.866 0 l S Q q 1 0 0 1 312.061 478.4085 cm 0 0 m 70.866 0 l S Q q 1 0 0 1 382.9272 478.4085 cm 0 0 m 70.866 0 l S Q q 1 0 0 1 453.7933 478.4085 cm 0 0 m 71.116 0 l S Q BT /GS1 gs /T1_2 1 Tf 8 0 0 8 109.4561 559.6108 Tm (\027\006\210\212\212\013 \214\t\220\006\002\002\006\n\004\b\t\213\214\002\ , )Tj 4.579 -1.2 Td (\021\017\036/\n)Tj 16.039 1.2 Td (1)Tj -0.829 -1.2 Td (\021, 52)Tj 9.687 1.2 Td (2)Tj -0.779 -1.2 Td (\027, 52)Tj 9.638 1.2 Td (3)Tj -0.833 -1.2 Td (\225, 68)Tj 9.692 1.2 Td (4)Tj -0.975 -1.2 Td (\016, 68)Tj /T1_0 1 Tf -50.656 -1.433 Td (\210\002\013\036\036 \n\017\022\030\024\002\027\024\036 \004\017\f\035\024\ \026\220\030\024\002\024\r)Tj 23.22 0 Td (2,84)Tj /Span<>> BDC ( )Tj EMC (\327)Tj /Span<>> BDC ( )Tj EMC (10)Tj 4.664 0 0 4.664 288.8838 541.2136 Tm (13)Tj 8 0 0 8 330.5742 538.5496 Tm (3,95)Tj /Span<>> BDC ( )Tj EMC (\327)Tj /Span<>> BDC ( )Tj EMC (10)Tj 4.664 0 0 4.664 359.7499 541.2136 Tm (12)Tj 8 0 0 8 404.6064 538.5496 Tm (3,5)Tj /Span<>> BDC ( )Tj EMC (\327)Tj /Span<>> BDC ( )Tj EMC (10)Tj 4.664 0 0 4.664 429.782 541.2136 Tm (9)Tj 8 0 0 8 472.3065 538.5496 Tm (1,55)Tj /Span<>> BDC ( )Tj EMC (\327)Tj /Span<>> BDC ( )Tj EMC (10)Tj 4.664 0 0 4.664 501.4822 541.2136 Tm (12)Tj 8 0 0 8 73.9508 527.0883 Tm (\210\002\013\036\036 \n\017\022\030\024\002\027\024\036 \004\017\f\035\024\ \026\027\026\220\030\024\002\024\r)Tj 23.812 0 Td (8)Tj /Span<>> BDC ( )Tj EMC (\327)Tj /Span<>> BDC ( )Tj EMC (10)Tj 4.664 0 0 4.664 284.1438 529.7523 Tm (11)Tj 8 0 0 8 330.5742 527.0883 Tm (5,75)Tj /Span<>> BDC ( )Tj EMC (\327)Tj /Span<>> BDC ( )Tj EMC (10)Tj 4.664 0 0 4.664 359.7499 529.7523 Tm (12)Tj 8 0 0 8 407.3464 527.0883 Tm (3)Tj /Span<>> BDC ( )Tj EMC (\327)Tj /Span<>> BDC ( )Tj EMC (10)Tj 4.664 0 0 4.664 427.0421 529.7523 Tm (9)Tj 8 0 0 8 474.3065 527.0883 Tm (9,5)Tj /Span<>> BDC ( )Tj EMC (\327)Tj /Span<>> BDC ( )Tj EMC (10)Tj 4.664 0 0 4.664 499.4822 529.7523 Tm (11)Tj 8 0 0 8 73.9508 515.627 Tm (\214\026\022\021\024\002\026\006\017\035\035\t)Tj 23.22 0 Td (1,42)Tj /Span<>> BDC ( )Tj EMC (\327)Tj /Span<>> BDC ( )Tj EMC (10)Tj 4.664 0 0 4.664 288.8838 518.291 Tm (12)Tj 8 0 0 8 341.162 515.627 Tm (10)Tj 4.664 0 0 4.664 349.162 518.291 Tm (11)Tj 8 0 0 8 404.6064 515.627 Tm (1,5)Tj /Span<>> BDC ( )Tj EMC (\327)Tj /Span<>> BDC ( )Tj EMC (10)Tj 4.664 0 0 4.664 429.782 518.291 Tm (9)Tj 8 0 0 8 474.3065 515.627 Tm (7,4)Tj /Span<>> BDC ( )Tj EMC (\327)Tj /Span<>> BDC ( )Tj EMC (10)Tj 4.664 0 0 4.664 499.4822 518.291 Tm (11)Tj /T1_3 1 Tf 8 0 0 8 73.9508 504.1657 Tm (Bi\233dobacterium )Tj /T1_0 1 Tf (spp.)Tj 23.22 0 Td (9,85)Tj /Span<>> BDC ( )Tj EMC (\327)Tj /Span<>> BDC ( )Tj EMC (10)Tj 4.664 0 0 4.664 288.8838 506.8297 Tm (11)Tj 8 0 0 8 345.494 504.1657 Tm (0)Tj 7.389 0 Td (4,1)Tj /Span<>> BDC ( )Tj EMC (\327)Tj /Span<>> BDC ( )Tj EMC (10)Tj 4.664 0 0 4.664 429.782 506.8297 Tm (9)Tj 8 0 0 8 474.3065 504.1657 Tm (5,5)Tj /Span<>> BDC ( )Tj EMC (\327)Tj /Span<>> BDC ( )Tj EMC (10)Tj 4.664 0 0 4.664 499.4822 506.8297 Tm (10)Tj /T1_3 1 Tf 8 0 0 8 73.9508 492.7044 Tm (Enterobacteriaceae)Tj /T1_0 1 Tf 23.22 0 Td (1,85)Tj /Span<>> BDC ( )Tj EMC (\327)Tj /Span<>> BDC ( )Tj EMC (10)Tj 4.664 0 0 4.664 288.8838 495.3684 Tm (12)Tj 8 0 0 8 330.5742 492.7044 Tm (1,40)Tj /Span<>> BDC ( )Tj EMC (\327)Tj /Span<>> BDC ( )Tj EMC (10)Tj 4.664 0 0 4.664 359.7499 495.3684 Tm (12)Tj 8 0 0 8 413.1942 492.7044 Tm (10)Tj 4.664 0 0 4.664 421.1942 495.3684 Tm (9)Tj 8 0 0 8 477.0465 492.7044 Tm (4)Tj /Span<>> BDC ( )Tj EMC (\327)Tj /Span<>> BDC ( )Tj EMC (10)Tj 4.664 0 0 4.664 496.7422 495.3684 Tm (11)Tj /T1_3 1 Tf 8 0 0 8 73.9508 481.2432 Tm (Salmonella)Tj /T1_0 1 Tf ( spp., )Tj /T1_3 1 Tf (Shigella)Tj /T1_0 1 Tf ( spp.)Tj 25.085 0 Td (0)Tj 7.732 0 Td (3)Tj /Span<>> BDC ( )Tj EMC (\327)Tj /Span<>> BDC ( )Tj EMC (10)Tj 4.664 0 0 4.664 356.1759 483.9072 Tm (9)Tj 8 0 0 8 416.3602 481.2432 Tm (0)Tj 7.732 0 Td (5)Tj /Span<>> BDC ( )Tj EMC (\327)Tj /Span<>> BDC ( )Tj EMC (10)Tj 4.664 0 0 4.664 497.9082 483.9072 Tm (8)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 9 0 0 9 70.8661 461.6892 Tm (\020\004\206\f\t\204\004 3.)Tj 0 0 0 1 k /GS1 gs /T1_3 1 Tf [( \n\013\026\016\026\024\031\023\025 \026\023\022\f\026-\032\026\016\021\ \n\n\005\032\026\016\025\002 \033\032\025\t\024\031\021\n\006\021\n\017 \ \003\025\013\032\n\005\025\n\024\020)0.5( \030\025\027\031\032\024\025\013\205\023\n\027)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf T* [(T)48(able 3.)]TJ 0 0 0 1 k /GS1 gs /T1_3 1 Tf [( Alpha-div)13.1(ersity indices of the mucosal microbio)13.4(ta of the div)13.1(er)-40(ticula)]TJ ET /GS2 gs q 1 0 0 1 70.8661 446.3873 cm 0 0 m 170.329 0 l S Q q 1 0 0 1 71.1161 425.5681 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 241.1949 446.3873 cm 0 0 m 70.866 0 l S Q q 1 0 0 1 241.1949 425.5681 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 312.061 446.3873 cm 0 0 m 70.866 0 l S Q q 1 0 0 1 312.061 425.5681 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 382.9272 446.3873 cm 0 0 m 70.866 0 l S Q q 1 0 0 1 382.9272 425.5681 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 453.7933 446.3873 cm 0 0 m 71.116 0 l S Q q 1 0 0 1 453.7933 425.5681 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 524.6594 425.5681 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 70.8661 425.3181 cm 0 0 m 170.329 0 l S Q q 1 0 0 1 71.1161 414.0988 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 241.1949 425.3181 cm 0 0 m 70.866 0 l S Q q 1 0 0 1 241.1949 414.0988 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 312.061 425.3181 cm 0 0 m 70.866 0 l S Q q 1 0 0 1 312.061 414.0988 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 382.9272 425.3181 cm 0 0 m 70.866 0 l S Q q 1 0 0 1 382.9272 414.0988 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 453.7933 425.3181 cm 0 0 m 71.116 0 l S Q q 1 0 0 1 453.7933 414.0988 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 524.6594 414.0988 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 70.8661 413.8488 cm 0 0 m 170.329 0 l S Q q 1 0 0 1 71.1161 402.6375 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 241.1949 413.8488 cm 0 0 m 70.866 0 l S Q q 1 0 0 1 241.1949 402.6375 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 312.061 413.8488 cm 0 0 m 70.866 0 l S Q q 1 0 0 1 312.061 402.6375 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 382.9272 413.8488 cm 0 0 m 70.866 0 l S Q q 1 0 0 1 382.9272 402.6375 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 453.7933 413.8488 cm 0 0 m 71.116 0 l S Q q 1 0 0 1 453.7933 402.6375 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 402.6375 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 402.3875 cm 0 0 m 170.329 0 l S Q q 1 0 0 1 71.1161 391.1763 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 241.1949 402.3875 cm 0 0 m 70.866 0 l S Q q 1 0 0 1 241.1949 391.1763 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 312.061 402.3875 cm 0 0 m 70.866 0 l S Q q 1 0 0 1 312.061 391.1763 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 382.9272 402.3875 cm 0 0 m 70.866 0 l S Q q 1 0 0 1 382.9272 391.1763 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 453.7933 402.3875 cm 0 0 m 71.116 0 l S Q q 1 0 0 1 453.7933 391.1763 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 391.1763 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 390.9263 cm 0 0 m 170.329 0 l S Q q 1 0 0 1 71.1161 379.715 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 241.1949 390.9263 cm 0 0 m 70.866 0 l S Q q 1 0 0 1 241.1949 379.715 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 312.061 390.9263 cm 0 0 m 70.866 0 l S Q q 1 0 0 1 312.061 379.715 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 382.9272 390.9263 cm 0 0 m 70.866 0 l S Q q 1 0 0 1 382.9272 379.715 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 453.7933 390.9263 cm 0 0 m 71.116 0 l S Q q 1 0 0 1 453.7933 379.715 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 379.715 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 379.465 cm 0 0 m 170.329 0 l S Q q 1 0 0 1 71.1161 368.2537 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 241.1949 379.465 cm 0 0 m 70.866 0 l S Q q 1 0 0 1 241.1949 368.2537 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 312.061 379.465 cm 0 0 m 70.866 0 l S Q q 1 0 0 1 312.061 368.2537 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 382.9272 379.465 cm 0 0 m 70.866 0 l S Q q 1 0 0 1 382.9272 368.2537 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 453.7933 379.465 cm 0 0 m 71.116 0 l S Q q 1 0 0 1 453.7933 368.2537 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 368.2537 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 368.0037 cm 0 0 m 170.329 0 l S Q q 1 0 0 1 241.1949 368.0037 cm 0 0 m 70.866 0 l S Q q 1 0 0 1 312.061 368.0037 cm 0 0 m 70.866 0 l S Q q 1 0 0 1 382.9272 368.0037 cm 0 0 m 70.866 0 l S Q q 1 0 0 1 453.7933 368.0037 cm 0 0 m 71.116 0 l S Q BT /GS1 gs /T1_2 1 Tf 8 0 0 8 98.4204 432.9527 Tm (\200\002\220\004\213\004\003\r\f\t \004\f\001\226\004-\006\004\213\b\002\ \002\206\006\004\213\t\235)Tj 21.998 0.6 Td (1)Tj -0.829 -1.2 Td (\021, 52)Tj 9.687 1.2 Td (2)Tj -0.779 -1.2 Td (\027, 52)Tj 9.638 1.2 Td (3)Tj -0.833 -1.2 Td (\225, 68)Tj 9.692 1.2 Td (4)Tj -0.975 -1.2 Td (\016, 68)Tj -50.656 -1.434 Td (\021\002\f\t\201\r\217\003\002 \017\020\036)Tj /T1_0 1 Tf 24.585 0.001 Td (665)Tj 8.858 0 Td (442)Tj 8.858 0 Td (568)Tj 8.858 0 Td (564)Tj -51.159 -1.434 Td (\205\017\035\024\020\036\027\036\021\017\004\036\f\022\024\036 \030\026\ \027\024\024\002\030\026\017\036 \(Faith\245s PD\))Tj 24.492 0 Td (41,0)Tj 8.858 0 Td (29,8)Tj 8.858 0 Td (32,9)Tj 8.858 0 Td (29,9)Tj -51.067 -1.433 Td (\222\027\007\036\022\f \223\026\0241)Tj 24.242 0 Td (670,4)Tj 8.858 0 Td (503,9)Tj 8.858 0 Td (636,7)Tj 8.858 0 Td (628,0)Tj -50.817 -1.433 Td (\222\027\007\036\022\f \234\036\027\027\024\027\026)Tj 24.742 0 Td (7,3)Tj 8.858 0 Td (5,4)Tj 8.858 0 Td (5,6)Tj 8.858 0 Td (6,0)Tj -51.317 -1.433 Td (\222\027\007\036\022\f \221\017\n\023\f\024\027\026)Tj 24.492 0 Td (0,98)Tj 9.108 0 Td (0,9)Tj 8.858 0 Td (0,9)Tj 8.858 0 Td (1,0)Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\033\030\031\030\213\b)-20.9(\035\231\213\233\t \021\032)50(\b)42(\032\231\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj -51.938 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 23, \023\0221)69(, 202)69(4)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 23, \023\0221)69(, 202)69(4)]TJ /T1_5 1 Tf 25 0 0 25 19.9277 56.0378 Tm (110)Tj ET endstream endobj 1388 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\034\002\220\006)-10(\026)11(\016\001\025\017\001\013\205 \024\220\n\002\025\f\220\025\026)11(\013 \201\220\r\016\002\026\220\n\215\007\025\r \221\002\220\022\r\025\006\ \221\013\007\220\026)11(\016\007\216\001\020\207 )]TJ 0 -1 TD [(\025\006)-10(\007\025\217\001\016\001\220\205\207 \201\220\r\016\002\026\220\n\215\007\ \205\002\001\025\203 \f\025\007\016\222\001\220 \(\221\220\007\025\026\001\ \025\016 \220\006\006)-10(\007\016\201\025\r\013\001\220\016\))]TJ 39.309 1 Td [(Mucosal micr)20(obiota of th)11(e div)12(er)-20(ticula in inflammator)-31(y )]TJ 1.089 -1 Td [(complications of div)12(er)-19.9(ticular disease \(a pilot study\))]TJ ET 0 0 0 1 K 1 j 1 J [0 2.997]0 d /GS1 gs q 1 0 0 1 46.0167 585.9841 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 43.0197 585.9841 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q [0 2.997]0 d q 1 0 0 1 46.0167 548.7763 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 43.0197 548.7763 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q 0 j 0 J q 1 0 0 1 42.5197 485.1071 cm 0 0 m 453.543 0 l S Q BT 0 0 0 1 k /T1_1 1 Tf 0.156 Tw 9 0 0 9 90.7087 730.4919 Tm [(P)45(A)45(TIENT)-9.9(S A)53(ND METHODS: in this pilo)13(t study using classical culture methods and analysis of 16S rDN)15.1(A librar)-37(ies )]TJ 0.065 Tw 0 -1.111 TD [(seq)14(uenced on the Illumina MiSeq platfor)-14(m, w)12(e character)-36.9(ized the mucosa-associated microbio)13(ta of four div)13(er)-40(ticula )]TJ 0.023 Tw T* (in resected colon specimens of patients.)Tj 0.303 Tw T* [(RESUL)30(T)-10(S: )0.5(in )0.5(all )0.5(the )0.5(sam)16(ples )0.5(the abund)26(ance )0.5(of Enterobacter)-36.9(ia )0.5(and )0.5(the )0.5(shif)-46(t )0.5(tow)13(ards )0.5(the )0.5(p)46(redominance of )]TJ -0.011 Tw T* [(Bacteroides in the ratio of Prev)13(o)13(tella-to-Bacteroides \(P/B\) w)13(as detected. In three sam)16(ples, Fir)-14(micutes p)46(rev)16(ailed ov)13(er )]TJ -0.02 Tw 0 -1.111 TD [(Bacteroidetes. )0.5(Also, in three sam)16(ples the balance in the microbial )0.5(landscape w)13(as strong)13(ly shif)-45.9(ted tow)13(ards one g)12(enus: )]TJ 0.023 Tw 0 -1.111 TD [(Bacteroidetes, P)18(ar)-41.9(vimonas, Akk)17.1(er)-14(mansia, or Bif)-43(idobacter)-36.9(ium.)]TJ 0.081 Tw T* [(C)21(ON)22(CLUSION: microbio)13(ta inside inf)-22(lamed div)13(er)-40(ticula rev)13(ealed the specif)-43(ic shif)-45.9(ts in the intestinal microbiome that )]TJ 0.023 Tw T* [(may contr)-36.9(ibute to the p)46(rog)14(ression of inf)-22(lammation in the div)13(er)-40(ticulum up to its inf)-22(lammator)-43(y destruction.)]TJ /T1_2 1 Tf 0.01 Tc -0.01 Tw 8 0 0 8 42.5596 635.2226 Tm [(KEYW)22(ORDS:)]TJ /T1_1 1 Tf 0 Tc 0.023 Tw 4.948 0 Td [( gut microbio)13.1(ta, div)13.1(er)-40(ticular disease)]TJ /T1_2 1 Tf 0.01 Tc -0.015 Tw -4.948 -1.909 Td [(FUNDIN)23(G)5( ST)51(A)46(TEMENT)62(:)]TJ /T1_1 1 Tf 0 Tc -0.01 Tw 9.165 0 Td [( This research w)13(as funded by R)22(ussian Science F)12(ound)26(ation \(g)14(rant N 22-16-00040\). The w)12(ork w)13(as per)-34(for)-14(med in frames of the )]TJ 0.023 Tw -9.17 -1.2 Td [(K)17(azan F)11(ederal U)22(niv)13(ersity S)27.9(trategic Academic Leadership Prog)14(ram \(P)66(RIORIT)-53.9(Y)39(-2030\))]TJ /T1_2 1 Tf 0.01 Tc 0.018 Tw 0.005 -1.909 Td [(C)19(ONFL)-33(ICT)5( OF)5( INTE)25(REST)62(:)]TJ /T1_1 1 Tf 0 Tc 0.023 Tw 9.871 0 Td [( The authors declare no conf)-22(lict of interest)]TJ /T1_2 1 Tf 0.027 Tc -0.043 Tw -9.871 -2.617 Td [(F)2.7(O)-5.2(R)8.2( C)-18(I)-16.2(T)44.9(A)37(T)-25.1(I)-1.8(ON:)]TJ /T1_3 1 Tf 0.014 Tc -0.035 Tw 6.278 0 Td [( S)-9.8(h)-7.8(a)-10.8(k)-40.6(i)-5.5(r)-15.3(o)-9.9(v)]TJ /Span<>> BDC ( )Tj EMC [(R)-20.9(.R)-20.9(.)-23.1(, P)-9.8(a)-7.1(n)-8.3(k)-25.3(r)-30.3(a)-17.7(t)-21.4(o)-9.9(v)-27.9(a)]TJ /Span<>> BDC ( )Tj EMC [(Y)51.8(.)-26.4(S)-9.2(.)-23(, S)-28.9(e)-11.1(n)-13.5(i)-2.7(n)-7.3(a)]TJ /Span<>> BDC ( )Tj EMC [(A)-22.5(.)-6.9(M)-6.6(.)-23(, B)-14.5(o)-12.8(u)-7.9(l)-7.8(y)-16.7(g)-28.5(i)-2.7(n)-7.3(a)]TJ /Span<>> BDC ( )Tj EMC [(E)-5.1(.)-23.4(A)-22.5(.)-23(, K)-30(a)-9.7(r)-30.3(a)-26.1(s)-22.5(e)-15.3(v)-27.9(a)]TJ /Span<>> BDC ( )Tj EMC [(O)11.9(.)-26.5(S)-9.1(.)-23(, G)-7.4(r)-56(i)-6.3(g)-9.7(o)-11.4(r)-60.1(y)-20(e)-15.3(v)-27.9(a)]TJ /Span<>> BDC ( )Tj EMC [(T)53(.)41.1(V)40.2(.)-23.1(, Y)16.8(a)-9.7(r)-29.8(u)-8(l)-27.9(l)-16.2(i)-2.7(n)-7.3(a)]TJ /Span<>> BDC ( )Tj EMC [(D)16.9(.R)-20.9(.)-23.1(, K)-29.9(a)-9.7(r)-38.6(p)-16.1(u)-9.1(k)-16.3(h)-13.5(i)-2.8(n)]TJ /Span<>> BDC ( )Tj EMC [(O)11.9(.)52.1(Y)51.8(.)14( )]TJ 0.023 Tc 0.188 Tw -6.283 -1.2 Td [(M)-5.7(u)-6.5(c)-6.5(o)-15.8(s)-24.7(a)-11.4(l m)-14.4(i)-5(c)-22.3(r)-15.8(o)-11.6(b)-19.5(i)-6.8(o)-15.8(t)-36.8(a o)-12.1(f t)-26.1(h)-15.1(e d)-15.8(i)-14.5(v)-18.7(e)-12.1(r)-59.7(t)-46.2(i)-5(c)-12.1(u)-8.4(l)-37.8(a i)-3.2(n i)-3.2(n)-13.5(f)-47.1(l)-37.7(a)-9.7(m)-6.2(m)-8.3(a)-18.2(t)-21.9(o)-11.7(r)-60.6(y c)-6.5(o)-9.2(m)-5.2(p)-20.1(l)-16.7(i)-5(c)-21.5(a)-18.2(t)-46.2(i)-6.8(o)-9.2(n)-11.2(s o)-12.1(f d)-15.8(i)-14.5(v)-18.7(e)-12.1(r)-59.7(t)-46.2(i)-5(c)-12.1(u)-8.4(l)-37.8(a)-10.2(r d)-15.8(i)-7.4(s)-22.9(e)-13(a)-26.6(s)-22.9(e \()20.4(A p)-18.6(i)-7.1(l)-20.9(o)-15.8(t s)-29.4(t)-22.2(u)-10.4(d)-20.5(y)19.6(\))10.4(. )]TJ /T1_1 1 Tf 0.033 Tc -0.033 Tw [(K)13.9(ol)3.7(op)2.4(r)3.1(o)3.4(k)-19.2(t)2.2(ol)3.6(o)-3.3(g)-13.2(i)6.7(a)5.9(.)]TJ /T1_3 1 Tf 0 Tc 0 Tw 56.693 0 Td ( )Tj 0.023 Tc 0.024 Tw -56.693 -1.2 Td [(2)-8.9(0)-3.8(2)8.8(4)10.2(;)9.8(2)-10.3(3)6(\()37.7(1)44.3(\))14.5(:)20.9(1)14(0)-23.4(8)-24.2(\226)50.8(1)29.8(1)12.6(6)5(. \()-0.9(i)-3.2(n R)-6.5(u)-21.9(s)-22.3(s)-15.5(.)43.2(\))10.4(. h)-17.2(t)-49.4(t)-29.3(p)-18.8(s)-8(:)2(/)84.7(/)36.4(d)-11.1(o)-12.5(i.)2.7(o)-11.8(r)-16.7(g)-22.8(/)11.2(1)14(0)6.5(.)-5.6(3)7.9(3)-15.9(8)1.3(7)4.6(8/)7.9(2)-8.9(0)9.3(7)-2(3)-13.3(-)41.3(7)10.7(55)-9(6)-26.7(-)9.7(2)-8.9(0)-3.8(2)8.8(4)-28.5(-)9.7(2)-10.3(3)-13.3(-)55.1(1)26.9(-)55.1(1)14(0)-23.4(8)-25.7(-)55.1(1)29.8(1)12.6(6)]TJ /T1_2 1 Tf 0.01 Tc -0.012 Tw 0.005 -2.617 Td [(\026\020\021\033\030)5( \020\036\017)5( \013\033\021\033\013\023\030\037\023:)]TJ /T1_1 1 Tf 0 Tc -0.007 Tw 10.517 0 Td ( \243\032\205\023\023\025\021\026 \200\025\021\026 \212\026\001\025\030\n\ \027\021\026, \013\026\f\031\030\032\026 \003\025\013\032\n\005\025\n\023\ \n\202\025\025 \215\021\t\024\025\024\205\024\026 \f\205\021\030\026\003\ \031\021\024\026\023\022\021\n\017 \003\031\030\025\203\025\021\020 \025\ )Tj /Span<>> BDC ( )Tj EMC (\005\025\n\023\n\202\025\025 \222\225\214, )Tj 0.036 Tw -10.522 -1.2 Td (\222\026\016\026\021\t\013\025\017 \(\032\025\027\n\023\204\t\013\025\017\ \) \f\031\030\031\032\026\023\022\021\020\017 \205\021\025\027\031\032\t\ \025\024\031\024, \205\023.)Tj /Span<>> BDC ( )Tj EMC (\222\032\031\003\023\031\027\t\013\026\002, \030.)Tj /Span<>> BDC ( )Tj EMC (18, \222\026\016\026\021\022, 420008, \212\n\t\t\025\002; \024\031\023.:\ )Tj /Span<>> BDC ( )Tj EMC (+7 \(927\) 030-09-50; e-mail: )Tj 0.023 Tw 0 -1.2 TD (kasfes@gmail.com, Dina.Yarullina@kpfu.ru.)Tj /T1_2 1 Tf 0.01 Tc 0.073 Tw 0.005 -1.2 Td [(ADDRESS)5( F)12.9(OR)5( C)19.1(ORRESPONDEN)23(CE:)]TJ /T1_1 1 Tf 0 Tc 0.078 Tw 14.161 0 Td [( Dina Y)49.1(arullina, Depar)-39.9(tment of Microbiology)42.1(, Institute of F)24(und)26(amental Medicine and Biology)42(, K)17(azan F)11(ederal )]TJ 0.023 Tw -14.166 -1.2 Td [(U)22(niv)13(ersity)42(, Kremlevsk)11.1(aya str)51.1(. 18, K)17(azan, 420008, R)22(ussian; tel.:)]TJ /Span<>> BDC ( )Tj EMC [(+7 \(927\) 030-09-50; e-mail: k)11(asfes@gmail.com; Dina.Y)49.1(arullina@kpfu.ru.)]TJ 0 Tw 0 -2.792 TD (\200\026\024\026 \033\n\t\024\205\033\023\031\021\025\002)Tj /Span<>> BDC ( )Tj EMC (\227 01.08.2023)Tj /Span<>> BDC ( )Tj EMC 19.488 0 Td (\n\t\023\031 \030\n\032\026\005\n\024\013\025)Tj /Span<>> BDC ( )Tj EMC (\227 23.11.2023)Tj /Span<>> BDC ( )Tj EMC 18.78 0 Td (\032\025\021\002\024\n \013)Tj /Span<>> BDC ( )Tj EMC (\033\205\005\023\025\013\026\203\025\025)Tj /Span<>> BDC ( )Tj EMC (\227 12.02.2024)Tj ( )Tj -38.268 -1.375 Td (Received)Tj /Span<>> BDC ( )Tj EMC (\227 01.08.2023)Tj /Span<>> BDC ( )Tj EMC 19.488 0 Td (Revised)Tj /Span<>> BDC ( )Tj EMC (\227 23.11.2023)Tj /Span<>> BDC ( )Tj EMC 18.78 0 Td (Accepted for publication)Tj /Span<>> BDC ( )Tj EMC (\227 12.02.2024)Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 42.5896 420.3799 Tm (\023\023\034\226\034\022\031\034)Tj 0 0 0 1 k /GS1 gs /T1_3 1 Tf 0.012 Tc 0.225 Tw 10 0 0 10 42.5197 396.0239 Tm (\200 \023\024\f\035\036\007\027\036\036 \007\036\f\016\021\017\035\036\021\ \017\036 \002\024\035\034\001\024\036 \r\027\017\n\026\027\017\036 \031\007\ \036)Tj 0 Tc 0 Tw (-)Tj 0.012 Tc 0.304 Tw 0 -1.218 TD [(\035\016\036\021\f\016 )0.5(\030\024\035\017 )0.5(\022\017\001\036\004\027\024\005 )0.5(\n\017\022\030\024\002\017\024\021\t )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 17.449 0 Td [(\023\026\021\024\020\036\027\036\036)12( )]TJ 0.456 Tw -17.449 -1.218 Td (\n\036\021\026\002\024\035\017\004\036\f\022\024\020\024 \f\017\027\007\030\ \024\n\026, \r\024\f\023\026\035\017\021\036\035\034\027\t\b, \024\027)Tj 0 Tc 0 Tw (-)Tj 0.012 Tc 0.354 Tw T* (\022\024\035\024\020\017\004\036\f\022\017\b, \027\036\005\030\024\007\036\ \020\036\027\036\030\026\021\017\r\027\t\b \017)Tj /Span<>> BDC ( )Tj EMC (\030\016\007\026 \007\030\031)Tj 0 Tc 0 Tw (-)Tj 0.012 Tc 0.342 Tw T* (\020\017\b \026\002\024\035\036\r\026\027\017\005 [1]. \200\017\007\024\ \r\024\005 \f\024\f\021\026\r \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\024\021\027\024)Tj 0 Tc 0 Tw (-)Tj 0.012 Tc 0.264 Tw T* (\001\036\027\017\036 \n\017\022\030\024\024\030\020\026\027\017\n\024\r\ , \r\b\024\007\016\013\017\b \r)Tj /Span<>> BDC ( )Tj EMC [(\n\017\022\030\024\002\017\024\021\031)12( )]TJ 0.211 Tw T* (\022\017\001\036\004\027\017\022\026, \004\030\036\r\t\004\026\005\027\024\ \n\027\024\020\024\024\002\030\026\027\t \017)Tj /Span<>> BDC ( )Tj EMC [(\026\r\017\f\016\021)12.1( )]TJ 0.199 Tw T* [(\024\021 \n\027\024\032\036\f\021\r\026 \235\026\022\021\024\030\024\r. \ \206\036\027\036\021\017\022\026, \r\024\030\026\f\021, \023\030\017\036\ \n)12( )]TJ 0.279 Tw T* [(\026\027\021\017\002\017\024\021\017\022\024\r, \007\017\036\021\026, \f\ \024\023\031\021\f\021\r\031\033\013\017\036 \026\002\024\035\036\r\026\ \027\017\016)12( )]TJ 0.114 Tw T* (\n\024\020\031\021 \r\035\017\016\021\034 \027\026)Tj /Span<>> BDC ( )Tj EMC [(\n\017\022\030\024\002\017\024\n, \004\021\024 \007\036\035\026\036\021 \ \036\020\024 \r\036\f\034\n\026)12( )]TJ 0.355 Tw T* (\007\017\027\026\n\017\004\027\024\005 \017)Tj /Span<>> BDC ( )Tj EMC [(\017\027\007\017\r\017\007\031\026\035\034\027\024\005 \220\022\024\f\017\ \f\021\036\n\024\005 [2].)12( )]TJ 0.315 Tw T* (\207\024\035\034\001\017\027\f\021\r\024 \023\031\002\035\017\022\026\006\ \017\005 \030\026\f\f\n\026\021\030\017\r\026\033\021 \017\n\036\027\036\ )Tj 0 Tc 0 Tw (-)Tj 0.012 Tc 0.299 Tw T* (\027\017\016 \035\017\001\034 \023\024\035\024\f\021\027\024\005 \n\017\022\ \030\024\002\017\024\021\t \023\030\017)Tj /Span<>> BDC ( )Tj EMC [(\030\026\035\017\004\027\t\b)12.1( )]TJ 0.286 Tw T* (\023\026\021\024\035\024\020\017\004\036\f\022\017\b \f\024\f\021\024\016\ \027\017\016\b, \r)Tj /Span<>> BDC ( )Tj EMC (\021\024 \r\030\036\n\016 \022\026\022 \023\030\017)Tj 0 Tc 0 Tw (-)Tj 0.012 Tc 0.391 Tw T* (\f\021\036\027\024\004\027\026\016 \n\017\022\030\024\002\017\024\021\026\ , \024\002\036\f\023\036\004\017\r\026\033\013\026\016 \022\024\035\024\027\ \017)Tj 0 Tc 0 Tw (-)Tj 0.012 Tc 0.44 Tw T* [(\026\006\017\024\027\027\031\033 \030\036\017\f\021\036\027\021\027\024\ \f\021\034, \017\031\004\036\027\026 \027\026\004\017\021\036\035\034\027\ \024)12( )]TJ 0.469 Tw T* [(\n\036\027\034\001\036. \222\r\036\f\021\027\t\036 \030\026\035\017\004\ \017\016 \n\036\032\007\031 \235\036\022\026\035\034\027\024\005)12( )]TJ 0.29 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\023\030\017\f\021\036\027\024\004\027\024\005 \n\017\022\030\024\002\017\ \024\021\024\005 [3] \024\f\024\002\024 \026\022\021\031\026\035\034)Tj 0 Tc 0 Tw (-)Tj 0.012 Tc 0.195 Tw T* (\027\t \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\007\017\r\036\030\021\017\022\031\035\016\030\027\024\005 \002\024\035\036\ \027\017 \(\212\207\), \007\035\016 \022\024\021\024)Tj 0 Tc 0 Tw (-)Tj 0.012 Tc 0.177 Tw T* [(\030\024\005 \b\026\030\026\022\021\036\030\027\024 \235\024\030\n\017\030\ \024\r\026\027\017\036 \024\f\024\002\024\005 \n\017\022\030\024\002\027\ \024\005)12( )]TJ 0.157 Tw T* (\f\030\036\007\t \r)Tj /Span<>> BDC ( )Tj EMC [(\026\n\022\027\031\021\024\n \023\030\024\f\021\030\026\027\f\021\r\036\ \007\017\r\036\030\021\017\022\031\035\026 [4].)12( )]TJ -0.017 Tw T* (\222\f\f\035\036\007\024\r\026\027\017\016, \023\024\f\r\016\013\036\027\ \027\t\036 \030\024\035\017 \022\017\001\036\004\027\024\005 \n\017\022\030\ \024)Tj 0 Tc 0 Tw (-)Tj 0.012 Tc 0.245 Tw T* (\002\017\024\021\t \r)Tj /Span<>> BDC ( )Tj EMC [(\023\030\024\020\030\036\f\f\017\030\024\r\026\027\017\017 \212\207, \027\ \036\n\027\024\020\024\004\017\f\035\036\027\027\t,)11.9( )]TJ 0.094 Tw T* (\026)Tj /Span<>> BDC ( )Tj EMC (\017\b \030\036\031\035\034\021\026\021\t)Tj /Span<>> BDC ( )Tj EMC (\227 \023\030\024\021\017\r\024\030\036\004\017\r\t [5]. \025\026\022 \023\ \030\026\r\017)Tj 0 Tc 0 Tw (-)Tj 0.012 Tc 0.262 Tw T* (\035\024, \024\027\017 \024\023\017\f\t\r\026\033\021 \017\n\036\027\036\ \027\017\016 \235\036\022\026\035\034\027\024\005 \n\017\022\030\024)Tj 0 Tc 0 Tw (-)Tj 0.012 Tc 0.322 Tw T* (\002\017\024\021\t. \200)Tj /Span<>> BDC ( )Tj EMC [(\007\024\f\021\031\023\027\024\005 \027\026\n \035\017\021\036\030\026\021\ \031\030\036 \024\002\027\026\030\031\032\036\027\026)12( )]TJ 0.462 Tw T* [(\024\007\027\026 \030\026\002\024\021\026, \023\024\f\r\016\013\036\027\027\ \026\016 \026\027\026\035\017\031 \n\017\022\030\024\002\017\024\021\t)12( )]TJ 0.142 Tw 23.244 34.098 Td (\030\036\036\006\017\030\024\r\026\027\027\t\b \023\030\036\023\026\030\ \026\021\024\r \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\b\030\024\027\017)Tj 0 Tc 0 Tw (-)Tj 0.012 Tc 0.05 Tw T* (\004\036\f\022\017\n \021\036\004\036\027\017\036\n \212\207 [6]. \025\030\ \024\n\036 \r\t\016\r\035\036\027\027\t\b \030\026\035\017)Tj 0 Tc 0 Tw (-)Tj 0.012 Tc 0.017 Tw T* (\004\017\005 \r)Tj /Span<>> BDC ( )Tj EMC (\n\017\022\030\024\002\027\024\n \023\036\005\026\032\036 \022\017\001\036\ \004\027\017\022\026 \n\036\032\007\031 \007\024\030\024)Tj 0 Tc 0 Tw (-)Tj 0.012 Tc 0.018 Tw T* (\r\t\n\017 \035\033\007\034\n\017 \017)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\026\n\017 \f)Tj /Span<>> BDC ( )Tj EMC (\212\207, \027\026)Tj /Span<>> BDC ( )Tj EMC [(\030\024\035\034 \022\017\001\036\004\027\024\005)12( )]TJ 0.065 Tw T* (\n\017\022\030\024\002\017\024\021\t \r)Tj /Span<>> BDC ( )Tj EMC (\023\026\021\024\020\036\027\036\036 \212\207 \031\022\026\t\r\026\033\ \021 \220\235\235\036\022\021\017\r)Tj 0 Tc 0 Tw (-)Tj 0.012 Tc 0.111 Tw T* (\027\024\f\021\034 \023\030\024\002\017\024\021\017\022\024\r \017)Tj /Span<>> BDC ( )Tj EMC (\021\024\023\017\004\036\f\022\024\020\024 \026\027\021\017\002\017\024\021\ \017\022\026 \030\017)Tj 0 Tc 0 Tw (-)Tj 0.012 Tc T* (\235\026\022\f\017\n\017\027\026 \r)Tj /Span<>> BDC ( )Tj EMC (\021\036\030\026\023\017\017 \212\207 [7,8].)Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 0.01 Tc 0.018 Tw 14 0 0 14 275.0305 310.7779 Tm [(\017\034\r\241)5( \031\032\032\r\034\226\037\023\026\022\031\025)]TJ 0 0 0 1 k /GS1 gs /T1_3 1 Tf 0 Tc 0.462 Tw 10 0 0 10 274.9606 286.4219 Tm [(\200\t\016\r\035\036\027\017\036 )0.6(\f\023\036\006\017\235\017\022\017 )0.6(\023\030\017\f\021\036\027\024\004\027\024\005 )0.5(\n\017\022\030\024\002\017\024\021\t )]TJ 0.407 Tw T* (\r\024\f\023\026\035\036\027\027\t\b \007\017\r\036\030\021\017\022\031\035\ \024\r \017)Tj /Span<>> BDC ( )Tj EMC (\024\006\036\027\022\026 \036\036 \r\035\017\016\027\017\016 )Tj 0.107 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\020\030\036\f\f\017\030\024\r\026\027\017\036 \212\207 \007\ \024)Tj /Span<>> BDC ( )Tj EMC (\r\024\f\023\026\035\017\021\036\035\034\027\t\b \024\f\035\024\032)Tj 0 Tw (-)Tj T* (\027\036\027\017\005, \021\030\036\002\031\033\013\017\b \b\017\030\031\030\ \020\017\004\036\f\022\024\005 \022\024\030\030\036\022\006\017\017.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 0.01 Tc 0.018 Tw 14 0 0 14 275.0305 213.3539 Tm [(\f\026\017\031\034\022\024\232)5( \031)5(\016)-18.3(\240\034)-31(\024)35(\037\226\232)]TJ 0 0 0 1 k /GS1 gs /T1_3 1 Tf 0 Tc 0.9 Tw 10 0 0 10 274.9606 188.9979 Tm (\215\030\024\r\036\007\036\027\024 \022\035\017\027\017\022\024-\035\026\ \002\024\030\026\021\024\030\027\024\036 \017\f\f\035\036\007\024\r\026\027\ \017\036 )Tj 0.351 Tw T* (\004\036\021\t\030\036\b \024\002\030\026\006\024\r \f\017\020\n\024\r\017\ \007\027\024\005 \022\017\001\022\017 \023\026\006\017\036\027\021\024\r\ , )Tj 0.309 Tw T* [(\027\026\b\024\007\017\r\001\017\b\f\016 )0.6(\027\026)]TJ /Span<>> BDC ( )Tj EMC 8.003 0 Td [(\035\036\004\036\027\017\017 )0.6(\r)]TJ /Span<>> BDC ( )Tj EMC 4.983 0 Td [(\024\021\007\036\035\036\027\017\017 )0.6(\022\024\035\024\023\030\024\022)]TJ 0 Tw (-)Tj 0.211 Tw -12.986 -1.218 Td (\021\024\035\024\020\017\017 \206\202\211\003 \253\217\036\f\023\031\002\ \035\017\022\026\027\f\022\026\016 \022\035\017\027\017\004\036\f\022\026\ \016 \002\024\035\034)Tj 0 Tw (-)Tj 0.218 Tw T* (\027\017\006\026 \204\017\027\007\030\026\r\026 \217\036\f\023\031\002\035\ \017\022\017 \230\026\021\026\030\f\021\026\027\273 \f)Tj /Span<>> BDC ( )Tj EMC (\235\036\r\030\026\035\016 )Tj 0.02 Tw T* (2020)Tj /Span<>> BDC ( )Tj EMC (\020. \023\024)Tj /Span<>> BDC ( )Tj EMC (\235\036\r\030\026\035\034 2022 \020. \204\031\032\004\017\027)Tj /Span<>> BDC ( )Tj EMC (\227 3, \032\036\027\013\017\027\026)Tj /Span<>> BDC ( )Tj EMC (\227 )Tj 0.113 Tw T* [(1. )0.5(\221\030\036\007\027\017\005 )0.5(\r\024\030\026\f\021)]TJ /Span<>> BDC ( )Tj EMC [(\227 )0.5(61,5)]TJ /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC 12.715 0 Td [(7,89 )0.5(\035\036\021. \025\035\017\027\017\004\036\f\022\017\036 )]TJ 0.269 Tw -12.715 -1.218 Td (\b\026\030\026\022\021\036\030\017\f\021\017\022\017 \023\026\006\017\036\ \027\021\024\r \024\021\030\026\032\036\027\t \r)Tj /Span<>> BDC ( )Tj EMC (\230\026\002\035\017\006\036 1. )Tj 0.545 Tw T* (\212\026\027\027\024\036 \017\f\f\035\036\007\024\r\026\027\017\036 \024\ \007\024\002\030\036\027\024 \035\024\022\026\035\034\027\t\n \220\021\017\ )Tj 0 Tw (-)Tj 0.472 Tw T* (\004\036\f\022\017\n \022\024\n\017\021\036\021\024\n \205\206\207\210\211\ \200\210 \025\026\026\027\f\022\017\005 \206\204\211 \024\021 )Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 0 Tw 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\033\030\031\030\213\b)-20.9(\035\231\213\233\t \021\032)50(\b)42(\032\231\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj /T1_5 1 Tf 25 0 0 25 505.5021 56.0378 Tm (109)Tj ET endstream endobj 1385 0 obj [1390 0 R] endobj 1386 0 obj <>stream q /GS0 gs /Fm0 Do Q 0 0 0 1 K 1 j 1 J [0 2.997]0 d /GS1 gs q 1 0 0 1 74.3631 294.5411 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 71.3661 294.5411 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q [0 2.997]0 d q 1 0 0 1 74.3631 257.3333 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 71.3661 257.3333 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q BT 0 0 0 1 k /T1_0 1 Tf 10 0 0 10 70.8661 724.8299 Tm (https://doi.org/10.33878/2073-7556-2024-23-1-108-116)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0.023 Tw 19 0 0 19 135.1273 695.3259 Tm [(\034\002\220\006)-10(\026)11(\016\001\025\017\001\013\205 \024\220\n\002\025\f\220\025\026)11(\013 \201\220\r\016\002\026\220\n\215\007\025\r )]TJ -2.265 -1.105 Td [(\221\002\220\022)-23.3(\r\025\006\221\013\007\220\026)11.1(\016\007\216\001\020\207 \025\006)-9.9(\007\025\217\001\016\001\220\205\207 \201\220\r\016\002\026\220\n\215\007\ \205\002\001\025\203 )]TJ 3.684 -1.105 Td [(\f\025\007\016\222\001\220 \(\221\220\007\025\026\001\025\016 \220\006\006\ )-9.9(\007\016\201\025\r\013\001\220\016\))]TJ 0 0 0 1 k /GS1 gs 0 Tw 14 0 0 14 70.8661 628.822 Tm [(\206\013\n\220\002\025\r\022)-23.2(\033)124(.\033)124(.)]TJ -0.069 Tc 0.069 Tw 8.162 0 0 8.162 146.3855 633.484 Tm [(1,)-69(2)]TJ 0 Tc 0.023 Tw 14 0 0 14 157.7061 628.822 Tm [(, \034\013\001\n\002\013\026)11.1(\025\r\013\022)-23.3(\200.\021.)]TJ -0.069 Tc 0.069 Tw 8.162 0 0 8.162 269.4752 633.484 Tm [(1,)-69(2)]TJ 0 Tc 0.023 Tw 14 0 0 14 280.7958 628.822 Tm [(, \021\016\001\220\001\013\022)-23.2(\b)-31(.\005.)]TJ 0 Tw 8.162 0 0 8.162 364.8727 633.484 Tm (3)Tj 0.023 Tw 14 0 0 14 369.5087 628.822 Tm [(, \214\215\007\020\202\220\001\013\022)-23.2(\t.\b)-31(.)]TJ 0 Tw 8.162 0 0 8.162 459.7172 633.484 Tm (3)Tj 14 0 0 14 464.3532 628.822 Tm (, )Tj -28.106 -1.143 Td [(\037)41(\013\002\013\006\016\r\013\022)-23.3(\036.\021.)]TJ 8.162 0 0 8.162 157.3758 617.484 Tm (3)Tj 0.023 Tw 14 0 0 14 162.0117 612.822 Tm [(, \031)68(\002\220\202)10(\025\002\216\016\r\013\022)-23.2(\032.\004.)]TJ 0 Tw 8.162 0 0 8.162 258.9268 617.484 Tm (3)Tj 0.023 Tw 14 0 0 14 263.5627 612.822 Tm [(, \027\002\215\007\007\220\001\013\022)-23.2(\255.\033)124(.)]TJ 0 Tw 8.162 0 0 8.162 352.6378 617.484 Tm (3)Tj 0.023 Tw 14 0 0 14 357.2737 612.822 Tm [(, \037)41(\013\002\221\215)21(\207\220\001\022)-23.2(\036.\200.)]TJ -0.069 Tc 0.069 Tw 8.162 0 0 8.162 457.8291 617.484 Tm [(1,)-69(2)]TJ 0 Tc 0 Tw 5.83 0 0 5.83 70.8661 598.4827 Tm (1)Tj 0.023 Tw 10 0 0 10 74.1775 595.1527 Tm [(\210\031\214)21(\036)20(\240 \004\036 \037)41(\013\222\013\001\006\n\220\203 \031)52(\005)21(\240 \005\220\001\222\201\002\013\r\013 \033\025\006\006\220\220 \(\215\007\ .\022)-23.2(\214\215)-20(\026)21(\007\016\002\025\r\013, \201.\022)-23.3(49, \202)62(.\022)-23.3(\037)41(\013\222\013\001\216, 4200)87(1)125(2, \033\025\006\006\220\205\))]TJ 0 Tw ( )Tj 5.83 0 0 5.83 70.8661 586.4827 Tm (2)Tj 0.023 Tw 10 0 0 10 74.1775 583.1527 Tm [(\031)83(\b)41(\240)31(\211 \253\033\016\006\221\215\f\007\220\n\013\001\006\n\013\205 \n)-10(\007\220\001\220\017\016\006\n\013\205 \f\025\007\216\001\220\227\013\273\ \005\211 \033)-21(\032 \(\036\002\016\001\f\215\002\202)10(\006\n\220\203 \026\002\013\n)-10(\026, \201.\022)-23.3(1)100(38, \202)62(.\022)-23.3(\037)41(\013\222\013\001\216, 42006)34(4, )]TJ 0 Tw -0.331 -1.2 Td (\033\025\006\006\220\205\))Tj ( )Tj 5.83 0 0 5.83 70.8661 562.4828 Tm (3)Tj 0.023 Tw 10 0 0 10 74.1775 559.1528 Tm [(\210\031)83(\b\036)20(\240 \004\036 \253\037)41(\013\222\013\001\006\n\220\203 \(\034\002\220\r\025\007\217\006\n\220\203\ \) \225\016\201\016\002\013\007\216\001\020\203 \215\001\220\r\016\002\006\ \220\026)11(\016\026\273 \(\215\007.\022)-23.3(\037)20(\002\016\024)-20.9(\007\016\r\006\n\013\205, \201.\022)-23.3(1)112(8, \202)62(.\022)-23.3(\037)41(\013\222\013\001\216, )]TJ -0.331 -1.2 Td (420008, \033\025\006\006\220\205\))Tj /T1_0 1 Tf 0.127 Tw 9 0 0 9 119.0551 528.6489 Tm (\037\036\035\034: \027\020\002\027\023\031\021\025\031 \t\033\031\203\025\ \f\025\013\025 \033\032\025\t\024\031\021\n\006\021\n\017 \003\025\013\032\ \n\005\025\n\024\020 \027\n\t\033\026\023\031\021\021\020\004 \030\025\027\ \031\032\024\025\013\205\023\n\027 \025)Tj /Span<>> BDC ( )Tj EMC (\n\203\031\021\013\026 \031\031 \027\023\025\002\021\025\002 )Tj 0.033 Tw 0 -1.111 TD (\021\026)Tj /Span<>> BDC ( )Tj EMC [(\033\032\n\202\032\031\t\t\025\032\n\027\026\021\025\031 )0.5(\030\025\027\031\032\024\025\013\205\023\002\032\021\n\017 )0.5(\005\n\023\031\016\021\025 \030\n)]TJ /Span<>> BDC ( )Tj EMC [(\027\n\t\033\026\023\025\024\031\023\022\021\020\004 )0.5(\n\t\023\n\204\021\031\021\025\017, \024\032\031\005\205\007\211\025\004\ \004\025\032\205\032\202\025\006\031\t\013\n\017 )]TJ 0 Tw T* (\013\n\032\032\031\013\203\025\025.)Tj 0.045 Tw T* [(\201\037\215\036\217\220\235 )0.5(\215)]TJ /Span<>> BDC ( )Tj EMC [(\240\036\220\255\200\235: \003\031\024\n\030\026\003\025 )0.6(\013\023\026\t\t\025\006\031\t\013\n\017 )0.5(\003\025\013\032\n\005\025\n\023\n\202\025\025 )0.6(\025)]TJ /Span<>> BDC ( )Tj EMC [(\t )0.5(\033\n\003\n\211\022\007 )0.5(\026\021\026\023\025\016\026 )0.5(\005\025\005\023\025\n\024\031\013 \033\n\t\023\031\030\n\027\026)]TJ 0 Tw (-)Tj 0.058 Tw T* (\024\031\023\022\021\n\t\024\031\017 \202\031\021\n\027 16S \032\212\217\ \222, \t\031\013\027\031\021\025\032\n\027\026\021\021\020\004 \021\026)Tj /Span<>> BDC ( )Tj EMC (\033\023\026\024\f\n\032\003\031 Illumina MiSeq, \033\032\n\027\031\030\031\ \021\n \033\025\023\n\024\021\n\031 \025\t\t\023\031\030\n)Tj 0 Tw (-)Tj -0.034 Tw 0 -1.111 TD [(\027\026\021\025\031 )0.6(\033\032\025\t\024\031\021\n\006\021\n\017 )0.5(\003\025\013\032\n\005\025\n\024\020 )0.7(\030\025\027\031\032\024\025\013\205\023\n\027 )0.6(\027)]TJ /Span<>> BDC ( )Tj EMC 21.037 0 Td [(\006\031\024\020\032\031\004 )0.6(\032\031\016\031\203\025\032\n\027\026\021\021\020\004 )0.6(\033\032\031\033\026\032\026\024\026\004 )0.6(\t\025\202\003\n\027\025\030\021\n\017 )0.5(\013\025\001\013\025 )]TJ 0.023 Tw -21.037 -1.111 Td (\205)Tj /Span<>> BDC ( )Tj EMC (\033\026\203\025\031\021\024\n\027, \n\033\031\032\025\032\n\027\026\021\ \021\020\004 \033\n)Tj /Span<>> BDC ( )Tj EMC (\033\n\027\n\030\205 \027\n\t\033\026\023\025\024\031\023\022\021\020\004\ \n\t\023\n\204\021\031\021\025\017 \030\025\027\031\032\024\025\013\205\ \023\002\032\021\n\017 \005\n\023\031\016\021\025.)Tj 0.136 Tw 0 -1.111 TD (\212\036\221\214\035\034\220\201\220\235: \021\026)Tj /Span<>> BDC ( )Tj EMC (\f\n\021\031 \027\020\032\026\204\031\021\021\n\202\n \025\021\030\025\027\ \025\030\205\026\023\022\021\n\202\n \004\026\032\026\013\024\031\032\026\ \003\025\013\032\n\005\025\n\024\020 \013\026\204\030\n\202\n \033\026\203\ \025\031\021\024\026, \027\n \027\t\031\004 )Tj 0.008 Tw T* (\n\005\032\026\016\203\026\004 \027)Tj /Span<>> BDC ( )Tj EMC [(\016\021\026\006\025\024\031\023\022\021\n\003 \013\n\023\025\006\031\t\024\ \027\031 )0.5(\n\005\021\026\032\205\204\031\021\020 \r\021\024\031\032\n\005\026\013\024\ \031\032\025\025, )0.5(\026)]TJ /Span<>> BDC ( )Tj EMC (\t\n\n\024\021\n\001\031\021\025\031 Prevotella-\013-Bacteroides )Tj 0.206 Tw T* (\(P/B\) \005\020\023\n \t\003\031\211\031\021\n \027)Tj /Span<>> BDC ( )Tj EMC (\t\024\n\032\n\021\205 \033\032\031\n\005\023\026\030\026\021\025\002 Ba\ cteroides. \216)Tj /Span<>> BDC ( )Tj EMC (\024\032\031\004 \n\005\032\026\016\203\026\004 Firmicutes \033\032\031\n\ \005\023\026\030\026\023\025 \021\026\030 )Tj 0 Tw T* (Bacteroidetes. \220\026\013 \204\031 \027)Tj /Span<>> BDC ( )Tj EMC (\024\032\031\004 \n\005\032\026\016\203\026\004 \032\026\027\021\n\027\031\ \t\025\031 \027)Tj /Span<>> BDC ( )Tj EMC (\003\025\013\032\n\005\021\n\003 \033\031\017\016\026\204\031 \005\020\023\ \n \016\021\026\006\025\024\031\023\022\021\n \t\003\031\211\031\021\n \027\ )Tj /Span<>> BDC ( )Tj EMC (\t\024\n\032\n)Tj (-)Tj 0.023 Tw T* (\021\205 \n\030\021\n\202\n \032\n\030\026: Parvimonas, Akkermansia, Bac\ teroides \025\023\025 Bifidobacterium.)Tj 0.183 Tw T* (\221\201\222\035\223\224\036\217\215\036: \026\021\026\023\025\016 \003\025\ \013\032\n\005\025\n\024\020 \027\021\205\024\032\025 \027\n\t\033\026\023\ \031\021\021\020\004 \030\025\027\031\032\024\025\013\205\023\n\027 \033\ \n\016\027\n\023\025\023 \027\020\002\027\025\024\022 \n\033\032\031\030\ \031\023\031\021\021\020\031 )Tj 0.03 Tw T* (\t\030\027\025\202\025 \027)Tj /Span<>> BDC ( )Tj EMC [(\013\025\001\031\006\021\n\003 \003\025\013\032\n\005\025\n\003\031, )0.5(\013\n\024\n\032\020\031 \003\n\202\205\024 )0.5(\t\033\n\t\n\005\t\024\027\n\027\026\024\022 )0.5(\033\032\n\202\032\031\t\t\025\032\n\027\026\021\025\007 \027\n\t\033\026\ \023\031\021\025\002 \027)]TJ /Span<>> BDC ( )Tj EMC (\030\025\027\031\032\024\025)Tj 0 Tw (-)Tj 0.057 Tw 0 -1.111 TD (\013\205\023\031 \027\033\023\n\024\022 \030\n)Tj /Span<>> BDC ( )Tj EMC (\031\202\n \027\n\t\033\026\023\025\024\031\023\022\021\n\017 \030\031\t\ \024\032\205\013\203\025\025. \n\023\205\006\031\021\021\020\031 \030\026\ \021\021\020\031 \033\032\031\030\t\024\026\027\023\002\007\024 \025\021\ \024\031\032\031\t \030\023\002 \033\n\021\025\003\026)Tj 0 Tw (-)Tj 0.143 Tw 0 -1.111 TD [(\021\025\002 )0.6(\003\031\004\026\021\025\016\003\n\027 )0.6(\033\026\024\n\202\031\021\031\016\026 )0.7(\016\026\005\n\023\031\027\026\021\025\002, )0.6(\033\n\025\t\013\026 )0.6(\021\n\027\020\004 )0.6(\003\031\024\n\030\n\027 )0.6(\r\f\f\031\013\024\025\027\021\n\202\n )0.5(\013\205\033\025\032\n\027\026\021\025\002 )0.6(\027\n\t\033\026\023\031\021\025\002 )]TJ 0.023 Tw T* (\030\025\027\031\032\024\025\013\205\023\n\027 \025)Tj /Span<>> BDC ( )Tj EMC (\033\032\n\f\025\023\026\013\024\025\013\025 \031\202\n \032\031\203\025\ \030\025\027\n\027.)Tj /T1_2 1 Tf 0.01 Tc 0.018 Tw 8 0 0 8 70.9061 353.3796 Tm [(\037\036\035\034\033\032\031\033)5( \030\036\027\032\026:)]TJ /T1_0 1 Tf 0 Tc 0.023 Tw 8.493 0 Td ( \003\025\013\032\n\005\025\n\024\026 \013\025\001\031\006\021\025\013\026\ , \030\025\027\031\032\024\025\013\205\023\002\032\021\026\002 \005\n\023\ \031\016\021\022)Tj /T1_2 1 Tf 0.01 Tc 0.167 Tw -8.493 -1.909 Td [(\023\030\022\027\034\025\023\037)5( \024\023\025\026\025\030\023\021\027\032\026\025\023\017:)]TJ /T1_0 1 Tf 0 Tc 0.172 Tw 13.737 0 Td ( \215\t\t\023\031\030\n\027\026\021\025\031 \027\020\033\n\023\021\031\021\ \n \033\032\025)Tj /Span<>> BDC ( )Tj EMC (\f\025\021\026\021\t\n\027\n\017 \033\n\030\030\031\032\204\013\031 \212\ \217\225 \(\202\032\026\021\024 \246 22-16-00040\). \212\026\005\n\024\026\ \027\020\033\n\023)Tj 0 Tw (-)Tj 0.304 Tw -13.742 -1.2 Td (\021\031\021\026 \027)Tj /Span<>> BDC ( )Tj EMC (\032\026\003\013\026\004 \032\n\202\032\026\003\003\020 \t\024\032\026\024\ \031\202\025\006\031\t\013\n\202\n \026\013\026\030\031\003\025\006\031\t\ \013\n\202\n \023\025\030\031\032\t\024\027\026 \222\026\016\026\021\t\013\ \n\202\n \(\032\025\027\n\023\204\t\013\n\202\n\) \f\031\030\031\032\026\ \023\022\021\n\202\n \205\021\025\027\031\032\t\025\024\031\024\026 )Tj 0 Tw 0 -1.2 TD (\(\212\215\255\212\215\220\036\220-2030\))Tj /T1_2 1 Tf 0.01 Tc 0.018 Tw 0.005 -1.909 Td [(\037\027\025\024\036\023\037\022)5( \023\025\022\033\021\033\030\027\032:)]TJ /T1_0 1 Tf 0 Tc 0.023 Tw 10.401 0 Td ( \201\027\024\n\032\020 \016\026\002\027\023\002\007\024 \n\005 \n\024\t\ \205\024\t\024\027\025\025 \013\n\021\f\023\025\013\024\026 \025\021\024\ \031\032\031\t\n\027)Tj /T1_2 1 Tf 0.033 Tc 0.048 Tw -10.401 -2.617 Td [(\020\036\017)4.7( \016\023\022\023\021\027\032\026\025\023\017:)]TJ /T1_3 1 Tf 0.023 Tc 0.053 Tw 9.22 0 Td ( \234\026\022\017\030\024\r)Tj /Span<>> BDC ( )Tj EMC (\217.\217., \215\026\027\022\030\026\021\024\r\026)Tj /Span<>> BDC ( )Tj EMC (\236.\221., \221\036\027\017\027\026)Tj /Span<>> BDC ( )Tj EMC (\202.\204., \207\031\035\t\020\017\027\026)Tj /Span<>> BDC ( )Tj EMC (\213.\202., \025\026\030\026\f\036\r\026)Tj /Span<>> BDC ( )Tj EMC (\210.\221., \206\030\017\020\024\030\034\036\r\026)Tj /Span<>> BDC ( )Tj EMC (\230.\200., \247\030\031\035\035\017\027\026)Tj /Span<>> BDC ( )Tj EMC [(\212.\217.,)23( )]TJ 0.078 Tw -9.225 -1.2 Td (\025\026\030\023\031\b\017\027)Tj /Span<>> BDC ( )Tj EMC (\210.\236. \215\030\017\f\021\036\027\024\004\027\026\016 \n\017\022\030\ \024\002\017\024\021\026 \007\017\r\036\030\021\017\022\031\035\024\r \023\ \030\017)Tj /Span<>> BDC ( )Tj EMC [(\r\024\f\023\026\035\017\021\036\035\034\027\t\b \024\f\035\024\032\027\036\ \027\017\016\b \007\017\r\036\030\021\017\022\031\035\016\030\027\024\005\ \002\024\035\036\027\017 \(\023\017\035\024\021\027\024\036)23( )]TJ -0.023 Tw 0 -1.2 TD (\017\f\f\035\036\007\024\r\026\027\017\036\). )Tj /T1_0 1 Tf 7.034 0 Td (\222\n\023\n\033\032\n\013\024\n\023\n\202\025\002.)Tj /T1_3 1 Tf 0.024 Tw ( 2024; \021.)Tj /Span<>> BDC ( )Tj EMC (23, \225)Tj /Span<>> BDC ( )Tj EMC 14.78 0 Td (1, \f.)Tj /Span<>> BDC ( )Tj EMC (108\226116. https://doi.org/10.33878/2073-7556-2024-23-1-108-116)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0 Tc 0.023 Tw 18 0 0 18 105.9076 231.164 Tm [(Mucosal micr)20.1(obiota of th)11(e div)12(er)-20(ticula in inflammator)-30.9(y )]TJ 0.545 -1.167 Td [(complications of div)12(er)-19.9(ticular disease \(a pilot study\))]TJ 0 0 0 1 k /GS1 gs 0 Tw 14 0 0 14 70.8661 185.6601 Tm [(Rais\022)-23.2(R.\022)-23.3(Shakir)20(ov)]TJ -0.069 Tc 0.069 Tw 8.162 0 0 8.162 160.8929 190.3221 Tm [(1,)-69(2)]TJ 0 Tc 0.023 Tw 14 0 0 14 172.2135 185.6601 Tm [(, Y)40(uliia\022)-23.3(S.\022)-23.3(P)20(ankr)21(atov)10(a)]TJ -0.069 Tc 0.069 Tw 8.162 0 0 8.162 291.6999 190.3221 Tm [(1,)-69(2)]TJ 0 Tc 0.023 Tw 14 0 0 14 303.0205 185.6601 Tm [(, Anastasiy)21.1(a\022)-23.3(M.\022)-23.3(Senina)]TJ 0 Tw 8.162 0 0 8.162 433.0623 190.3221 Tm (3)Tj 14 0 0 14 437.6982 185.6601 Tm (, )Tj -26.202 -1.143 Td [(Eugenia\022)-23.2(A)-31(.\022)-23.3(Bouly)10(gina)]TJ 8.162 0 0 8.162 192.4623 174.3221 Tm (3)Tj 0.023 Tw 14 0 0 14 197.0983 169.6601 Tm [(, Olga\022)-23.2(S.\022)-23.3(K)41(ar)21(ase)11(v)10(a)]TJ 0 Tw 8.162 0 0 8.162 304.1117 174.3221 Tm (3)Tj 0.023 Tw 14 0 0 14 308.7476 169.6601 Tm [(, T)40(atiana\022)-23.2(V)62(.\022)-23.3(Grigor)-30.9(y)10(e)11(v)9.9(a)]TJ 0 Tw 8.162 0 0 8.162 440.932 174.3221 Tm (3)Tj 14 0 0 14 445.568 169.6601 Tm (, )Tj -26.764 -1.143 Td [(Dina\022)-23.3(R.\022)-23.2(Y)49.9(ar)10.1(ullina)]TJ 8.162 0 0 8.162 164.4766 158.3221 Tm (3)Tj 0.023 Tw 14 0 0 14 169.1126 153.6601 Tm [(, Oleg\022)-23.2(Y)45(.\022)-23.3(K)41(arpukhin)]TJ -0.069 Tc 0.069 Tw 8.162 0 0 8.162 279.9332 158.3221 Tm [(1,)-69(2)]TJ 0 Tc 0 Tw 5.83 0 0 5.83 70.8661 139.3208 Tm (1)Tj 0.023 Tw 10 0 0 10 74.1775 135.9908 Tm [(K)41(a)20(z)15(an State Medical Univ)12(er)20(sit)-19.9(y \(Butler)20.1(ov)10(a\022)-23.3(st., 49, K)41(a)19.9(z)15(an, 4200)87(1)125(2, Russia\))]TJ 0 Tw ( )Tj 5.83 0 0 5.83 70.8661 127.3208 Tm (2)Tj 0.023 Tw 10 0 0 10 74.1775 123.9908 Tm [(Republican Clinical Hospital \(Or)31.1(enbur)31(g tr)21(act, 1)99.9(38, K)41(a)20(z)15(an, 42006)34(4, Russia\))]TJ 0 Tw ( )Tj 5.83 0 0 5.83 70.8661 115.3209 Tm (3)Tj 0.023 Tw 10 0 0 10 74.1775 111.9909 Tm [(K)41(a)20(z)15(an F)20(eder)21(al Univ)12.1(er)20(sit)-20(y \(Kr)31(emle)11(v)10(skay)21(a\022)-23.3(st., 1)112(8, K)41(a)20(z)15(an, 420008, Russia\))]TJ /T1_0 1 Tf 0.028 Tw 9 0 0 9 119.0551 93.4869 Tm [(AIM: to identify the specif)-42.9(icity of the mucosal microbio)13.1(ta of inf)-22(lamed div)13(er)-40(ticula and to assess its inf)-22(luence on the )]TJ 0.023 Tw 0 -1.111 TD [(p)46(rog)14(ression of div)13(er)-40(ticular disease to inf)-21.9(lammator)-42.9(y com)16(plications req)14(uir)-37(ing surg)12(er)-43(y)32(.)]TJ ET 1 0.68 0 0.12 k /GS0 gs q 1 0 0 1 70.8661 537.1533 cm 0 0 m 0 0 l 0 -11.339 l 42.52 -11.339 l 42.52 0 l h f Q BT 0 0 0 0 k /T1_2 1 Tf 0 Tw 9 0 0 9 76.0071 528.226 Tm (\021\033\r\035\f\033)Tj ET 1 0.68 0 0.12 k q 1 0 0 1 70.8661 101.9912 cm 0 0 m 0 0 l 0 -11.339 l 42.52 -11.339 l 42.52 0 l h f Q BT 0 0 0 0 k /T1_2 1 Tf 9 0 0 9 73.5728 93.0639 Tm (ABSTRACT)Tj 1 0.68 0 0.12 k /T1_1 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\033\030\031\030\213\b)-20.9(\035\231\213\233\t \021\032)50(\b)42(\032\231\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj -51.938 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 23, \023\0221)69(, 202)69(4)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 23, \023\0221)69(, 202)69(4)]TJ /T1_4 1 Tf 25 0 0 25 20.7902 56.0378 Tm (108)Tj ET q 0 g 0 G 0 j 0 J /Fm1 Do Q 0 0 0 0 k 396.85 725.67 59.155 11.338 re f /PlacedPDF /MC0 BDC q 397.481 736.808 m 397.242 736.808 397.049 736.616 397.049 736.376 c 397.049 736.376 l 397.049 726.285 l 397.049 726.045 397.242 725.853 397.481 725.853 c 397.481 725.853 l 455.382 725.853 l 455.62 725.853 455.815 726.045 455.815 726.285 c 455.815 726.285 l 455.815 736.376 l 455.815 736.616 455.62 736.808 455.382 736.808 c 455.382 736.808 l h W n q 0 g -0.0000005 -10.9560913 -10.9560913 0.0000005 426.4320445 736.8086309 cm BX /Sh0 sh EX Q Q q 396.85 725.67 59.155 11.337 re W n 0 0 0 0.84 k q 1 0 0 1 413.5634 732.4249 cm 0 0 m -0.025 0.1 -0.063 0.196 -0.112 0.287 c -0.157 0.374 -0.218 0.451 -0.292 0.515 c -0.37 0.582 -0.46 0.632 -0.558 0.664 c -0.669 0.701 -0.786 0.719 -0.903 0.717 c -1.076 0.722 -1.247 0.681 -1.4 0.6 c -1.536 0.526 -1.652 0.42 -1.74 0.292 c -1.83 0.158 -1.895 0.008 -1.934 -0.149 c -2.018 -0.48 -2.018 -0.827 -1.934 -1.158 c -1.896 -1.316 -1.83 -1.466 -1.74 -1.602 c -1.653 -1.731 -1.536 -1.837 -1.4 -1.912 c -1.247 -1.993 -1.076 -2.033 -0.903 -2.029 c -0.774 -2.032 -0.647 -2.006 -0.528 -1.955 c -0.427 -1.906 -0.337 -1.837 -0.263 -1.753 c -0.185 -1.665 -0.124 -1.563 -0.082 -1.453 c -0.034 -1.338 0 -1.218 0.019 -1.094 c 0.635 -1.094 l 0.624 -1.297 0.578 -1.497 0.497 -1.684 c 0.421 -1.857 0.312 -2.015 0.175 -2.146 c 0.039 -2.277 -0.123 -2.379 -0.3 -2.446 c -0.492 -2.519 -0.695 -2.555 -0.9 -2.552 c -1.15 -2.557 -1.397 -2.506 -1.625 -2.404 c -1.829 -2.307 -2.01 -2.169 -2.157 -1.997 c -2.308 -1.821 -2.423 -1.617 -2.497 -1.397 c -2.655 -0.924 -2.655 -0.412 -2.497 0.061 c -2.423 0.281 -2.307 0.485 -2.157 0.661 c -2.01 0.833 -1.829 0.973 -1.625 1.07 c -1.398 1.174 -1.15 1.226 -0.9 1.222 c -0.707 1.223 -0.515 1.196 -0.329 1.14 c -0.159 1.088 0.001 1.006 0.144 0.898 c 0.278 0.793 0.39 0.662 0.473 0.513 c 0.562 0.349 0.615 0.167 0.629 -0.019 c 0 -0.019 l 0 0 l f Q q 1 0 0 1 414.6923 733.5723 cm 0 0 m 0.584 0 l 0.584 -1.328 l 0.662 -1.204 0.771 -1.103 0.9 -1.033 c 1.046 -0.951 1.213 -0.91 1.381 -0.914 c 1.627 -0.9 1.869 -0.979 2.058 -1.137 c 2.234 -1.312 2.325 -1.556 2.305 -1.803 c 2.305 -3.596 l 1.716 -3.596 l 1.716 -1.976 l 1.724 -1.817 1.678 -1.66 1.585 -1.53 c 1.486 -1.43 1.347 -1.379 1.206 -1.392 c 1.114 -1.39 1.024 -1.408 0.94 -1.445 c 0.865 -1.479 0.798 -1.529 0.744 -1.591 c 0.687 -1.656 0.645 -1.73 0.616 -1.812 c 0.586 -1.896 0.571 -1.986 0.571 -2.077 c 0.571 -3.615 l 0 -3.615 l 0 0 l f Q q 1 0 0 1 418.0385 731.1235 cm 0 0 m 0 -0.099 0.014 -0.198 0.043 -0.292 c 0.069 -0.382 0.112 -0.466 0.17 -0.54 c 0.229 -0.611 0.304 -0.669 0.388 -0.709 c 0.486 -0.754 0.594 -0.776 0.702 -0.773 c 0.845 -0.78 0.987 -0.742 1.108 -0.664 c 1.217 -0.582 1.296 -0.468 1.336 -0.337 c 1.881 -0.337 l 1.827 -0.603 1.675 -0.838 1.456 -0.996 c 1.35 -1.073 1.231 -1.131 1.105 -1.169 c 0.971 -1.208 0.831 -1.229 0.691 -1.227 c 0.509 -1.227 0.328 -1.191 0.16 -1.121 c 0.007 -1.063 -0.13 -0.972 -0.244 -0.855 c -0.356 -0.73 -0.44 -0.583 -0.491 -0.422 c -0.548 -0.243 -0.576 -0.056 -0.574 0.133 c -0.575 0.313 -0.545 0.493 -0.486 0.664 c -0.426 0.826 -0.335 0.974 -0.22 1.102 c 0.004 1.375 0.338 1.534 0.691 1.535 c 0.883 1.539 1.072 1.495 1.243 1.408 c 1.402 1.326 1.541 1.209 1.649 1.067 c 1.759 0.922 1.838 0.757 1.883 0.582 c 1.932 0.396 1.945 0.203 1.92 0.013 c 0 0.013 l 0 0 l 1.342 0.377 m 1.335 0.468 1.315 0.557 1.283 0.643 c 1.253 0.724 1.209 0.798 1.153 0.863 c 1.097 0.922 1.03 0.97 0.957 1.004 c 0.874 1.043 0.783 1.063 0.691 1.062 c 0.6 1.062 0.509 1.044 0.425 1.009 c 0.345 0.976 0.273 0.926 0.213 0.863 c 0.153 0.799 0.105 0.724 0.072 0.643 c 0.037 0.559 0.017 0.468 0.014 0.377 c 1.355 0.377 l h f Q q 1 0 0 1 422.1581 731.7051 cm 0 0 m -0.012 0.144 -0.082 0.276 -0.194 0.366 c -0.31 0.452 -0.451 0.495 -0.595 0.489 c -0.675 0.488 -0.755 0.476 -0.831 0.452 c -0.918 0.424 -0.998 0.375 -1.062 0.311 c -1.142 0.229 -1.202 0.131 -1.24 0.024 c -1.29 -0.132 -1.312 -0.296 -1.304 -0.459 c -1.304 -0.569 -1.292 -0.677 -1.267 -0.784 c -1.244 -0.885 -1.202 -0.983 -1.145 -1.07 c -1.09 -1.154 -1.016 -1.224 -0.93 -1.275 c -0.833 -1.33 -0.722 -1.356 -0.611 -1.352 c -0.457 -1.357 -0.307 -1.301 -0.194 -1.195 c -0.078 -1.077 -0.005 -0.922 0.011 -0.757 c 0.587 -0.757 l 0.556 -1.055 0.419 -1.332 0.202 -1.538 c -0.022 -1.721 -0.306 -1.815 -0.595 -1.803 c -0.777 -1.806 -0.958 -1.771 -1.126 -1.7 c -1.293 -1.642 -1.445 -1.547 -1.57 -1.421 c -1.68 -1.297 -1.763 -1.151 -1.814 -0.993 c -1.87 -0.822 -1.898 -0.643 -1.896 -0.462 c -1.898 -0.276 -1.871 -0.091 -1.817 0.087 c -1.766 0.252 -1.682 0.405 -1.57 0.537 c -1.459 0.664 -1.323 0.766 -1.168 0.834 c -0.991 0.914 -0.798 0.955 -0.603 0.954 c -0.457 0.954 -0.311 0.935 -0.17 0.895 c -0.039 0.858 0.084 0.799 0.194 0.72 c 0.302 0.643 0.393 0.543 0.459 0.428 c 0.531 0.298 0.572 0.155 0.582 0.008 c 0 0.008 l 0 0 l f Q q 1 0 0 1 423.2177 733.5723 cm 0 0 m 0.577 0 l 0.577 -2.048 l 1.615 -0.985 l 2.322 -0.985 l 1.323 -1.944 l 2.417 -3.604 l 1.716 -3.604 l 0.919 -2.337 l 0.577 -2.669 l 0.577 -3.604 l 0 -3.604 l h f Q q 1 0 0 1 427.0585 732.5762 cm 0 0 m 0.436 0 l 0.436 0.218 l 0.429 0.352 0.448 0.486 0.488 0.614 c 0.521 0.705 0.577 0.786 0.651 0.85 c 0.717 0.905 0.795 0.943 0.879 0.961 c 0.966 0.979 1.056 0.988 1.145 0.988 c 1.28 0.993 1.416 0.981 1.548 0.954 c 1.548 0.505 l 1.509 0.516 1.469 0.523 1.429 0.528 c 1.379 0.532 1.33 0.532 1.28 0.528 c 1.209 0.53 1.14 0.511 1.081 0.473 c 1.019 0.419 0.987 0.337 0.999 0.255 c 0.999 -0.011 l 1.498 -0.011 l 1.498 -0.441 l 1.009 -0.441 l 1.009 -2.622 l 0.436 -2.622 l 0.436 -0.428 l 0.005 -0.428 l 0.005 0 l 0 0 l f Q q 1 0 0 1 430.1 729.8965 cm 0 0 m -0.191 -0.003 -0.381 0.032 -0.559 0.104 c -0.715 0.167 -0.856 0.264 -0.972 0.388 c -1.091 0.512 -1.181 0.659 -1.238 0.82 c -1.356 1.18 -1.356 1.567 -1.238 1.925 c -1.181 2.087 -1.091 2.234 -0.972 2.358 c -0.856 2.481 -0.715 2.578 -0.559 2.643 c -0.199 2.78 0.198 2.78 0.558 2.643 c 0.714 2.578 0.855 2.481 0.972 2.358 c 1.09 2.234 1.181 2.087 1.237 1.925 c 1.355 1.567 1.355 1.18 1.237 0.82 c 1.181 0.659 1.09 0.512 0.972 0.388 c 0.855 0.266 0.713 0.169 0.558 0.106 c 0.38 0.034 0.191 -0.002 0 0 c 0 0.454 m 0.115 0.451 0.23 0.479 0.332 0.534 c 0.424 0.586 0.502 0.659 0.562 0.746 c 0.624 0.836 0.669 0.936 0.695 1.041 c 0.752 1.26 0.752 1.491 0.695 1.71 c 0.669 1.816 0.625 1.916 0.562 2.005 c 0.502 2.091 0.423 2.163 0.332 2.215 c 0.123 2.323 -0.126 2.323 -0.335 2.215 c -0.427 2.163 -0.505 2.091 -0.566 2.005 c -0.628 1.916 -0.673 1.816 -0.699 1.71 c -0.756 1.491 -0.756 1.26 -0.699 1.041 c -0.672 0.936 -0.627 0.836 -0.566 0.746 c -0.506 0.659 -0.427 0.586 -0.335 0.534 c -0.232 0.478 -0.117 0.451 0 0.454 c f Q q 1 0 0 1 431.8979 732.5762 cm 0 0 m 0.531 0 l 0.531 -0.505 l 0.55 -0.43 0.583 -0.359 0.629 -0.297 c 0.681 -0.229 0.74 -0.167 0.807 -0.114 c 0.877 -0.059 0.956 -0.014 1.039 0.019 c 1.123 0.053 1.213 0.07 1.304 0.069 c 1.52 0.069 l 1.52 -0.486 l 1.395 -0.467 l 1.269 -0.467 l 1.178 -0.468 1.087 -0.488 1.004 -0.526 c 0.917 -0.565 0.839 -0.625 0.778 -0.699 c 0.716 -0.783 0.669 -0.878 0.643 -0.98 c 0.604 -1.104 0.584 -1.233 0.586 -1.362 c 0.586 -2.603 l 0.01 -2.603 l 0.01 0 l 0 0 l f Q q 1 0 0 1 437.3666 729.9683 cm 0 0 m -0.577 0 l -0.577 0.364 l -0.649 0.23 -0.759 0.121 -0.893 0.047 c -1.022 -0.029 -1.169 -0.07 -1.32 -0.072 c -1.595 -0.095 -1.866 0.002 -2.064 0.194 c -2.234 0.413 -2.316 0.687 -2.295 0.964 c -2.295 2.608 l -1.719 2.608 l -1.719 1.014 l -1.735 0.843 -1.689 0.67 -1.588 0.531 c -1.492 0.433 -1.357 0.382 -1.219 0.39 c -1.116 0.387 -1.012 0.406 -0.917 0.446 c -0.84 0.479 -0.772 0.531 -0.72 0.595 c -0.667 0.661 -0.63 0.738 -0.611 0.82 c -0.588 0.911 -0.577 1.003 -0.577 1.097 c -0.577 2.611 l 0 2.611 l 0 0 l f Q q 1 0 0 1 437.9877 732.5762 cm 0 0 m 0.545 0 l 0.545 -0.353 l 0.617 -0.209 0.736 -0.094 0.882 -0.026 c 1.03 0.04 1.19 0.073 1.352 0.072 c 1.535 0.075 1.717 0.038 1.883 -0.037 c 2.031 -0.106 2.161 -0.208 2.263 -0.334 c 2.366 -0.465 2.442 -0.615 2.489 -0.775 c 2.54 -0.948 2.566 -1.127 2.566 -1.307 c 2.566 -1.479 2.542 -1.651 2.497 -1.817 c 2.455 -1.973 2.385 -2.121 2.29 -2.252 c 2.099 -2.522 1.789 -2.682 1.458 -2.68 c 1.369 -2.681 1.28 -2.674 1.193 -2.659 c 1.11 -2.644 1.028 -2.618 0.951 -2.584 c 0.875 -2.552 0.802 -2.509 0.736 -2.457 c 0.671 -2.406 0.615 -2.343 0.571 -2.273 c 0.571 -3.575 l -0.005 -3.575 l -0.005 0 l 0 0 l 2.008 -1.307 m 2.008 -1.191 1.993 -1.076 1.963 -0.964 c 1.936 -0.859 1.89 -0.759 1.828 -0.669 c 1.768 -0.584 1.69 -0.514 1.599 -0.462 c 1.503 -0.409 1.395 -0.382 1.286 -0.385 c 1.072 -0.372 0.867 -0.467 0.738 -0.638 c 0.607 -0.836 0.543 -1.072 0.555 -1.31 c 0.554 -1.433 0.57 -1.557 0.603 -1.676 c 0.631 -1.781 0.68 -1.879 0.747 -1.965 c 0.809 -2.044 0.886 -2.109 0.975 -2.157 c 1.071 -2.206 1.178 -2.23 1.286 -2.229 c 1.401 -2.232 1.517 -2.205 1.618 -2.148 c 1.708 -2.096 1.785 -2.025 1.843 -1.939 c 1.903 -1.85 1.945 -1.751 1.968 -1.646 c 1.995 -1.535 2.008 -1.421 2.008 -1.307 c f Q q 1 0 0 1 443.5127 729.9683 cm 0 0 m -0.545 0 l -0.545 0.353 l -0.616 0.211 -0.734 0.099 -0.879 0.034 c -1.027 -0.031 -1.187 -0.065 -1.349 -0.064 c -1.532 -0.067 -1.714 -0.03 -1.88 0.045 c -2.028 0.113 -2.158 0.214 -2.26 0.34 c -2.364 0.47 -2.441 0.62 -2.486 0.781 c -2.538 0.958 -2.564 1.143 -2.563 1.328 c -2.568 1.536 -2.536 1.742 -2.468 1.938 c -2.41 2.097 -2.319 2.242 -2.202 2.364 c -2.101 2.471 -1.977 2.555 -1.838 2.608 c -1.705 2.659 -1.563 2.685 -1.421 2.685 c -1.338 2.685 -1.256 2.678 -1.174 2.664 c -1.091 2.648 -1.01 2.624 -0.932 2.589 c -0.855 2.556 -0.783 2.514 -0.717 2.462 c -0.652 2.411 -0.597 2.349 -0.553 2.279 c -0.553 3.606 l 0.024 3.606 l 0.024 0 l 0 0 l -2.008 1.277 m -2.009 1.166 -1.994 1.056 -1.965 0.948 c -1.939 0.845 -1.896 0.748 -1.835 0.661 c -1.777 0.578 -1.699 0.508 -1.61 0.459 c -1.404 0.355 -1.162 0.355 -0.956 0.459 c -0.866 0.512 -0.789 0.585 -0.73 0.671 c -0.671 0.762 -0.626 0.862 -0.6 0.966 c -0.572 1.076 -0.558 1.188 -0.558 1.301 c -0.543 1.542 -0.612 1.781 -0.751 1.979 c -0.88 2.14 -1.078 2.229 -1.283 2.22 c -1.402 2.224 -1.52 2.196 -1.623 2.138 c -1.714 2.083 -1.793 2.009 -1.852 1.92 c -1.911 1.828 -1.954 1.725 -1.977 1.617 c -1.999 1.505 -2.01 1.392 -2.008 1.277 c f Q q 1 0 0 1 446.3252 730.5499 cm 0 0 m -0.004 -0.052 0.005 -0.104 0.026 -0.151 c 0.052 -0.185 0.094 -0.202 0.136 -0.197 c 0.197 -0.197 l 0.223 -0.2 0.25 -0.2 0.276 -0.197 c 0.276 -0.595 l 0.199 -0.619 l 0.101 -0.64 l 0 -0.656 l -0.085 -0.656 l -0.187 -0.66 -0.288 -0.635 -0.377 -0.584 c -0.461 -0.528 -0.516 -0.437 -0.528 -0.337 c -0.648 -0.451 -0.792 -0.534 -0.951 -0.579 c -1.106 -0.628 -1.269 -0.654 -1.432 -0.656 c -1.546 -0.657 -1.659 -0.641 -1.769 -0.608 c -1.872 -0.579 -1.967 -0.531 -2.053 -0.468 c -2.136 -0.405 -2.203 -0.324 -2.25 -0.231 c -2.3 -0.127 -2.326 -0.012 -2.324 0.104 c -2.33 0.24 -2.299 0.375 -2.236 0.497 c -2.181 0.594 -2.101 0.675 -2.005 0.733 c -1.905 0.791 -1.795 0.833 -1.681 0.855 c -1.562 0.88 -1.442 0.899 -1.32 0.914 c -1.222 0.933 -1.123 0.947 -1.022 0.956 c -0.938 0.963 -0.855 0.977 -0.773 0.999 c -0.708 1.014 -0.649 1.046 -0.6 1.092 c -0.556 1.144 -0.533 1.211 -0.536 1.28 c -0.534 1.344 -0.553 1.408 -0.59 1.46 c -0.624 1.507 -0.668 1.544 -0.72 1.569 c -0.775 1.596 -0.834 1.613 -0.895 1.62 c -0.955 1.624 -1.016 1.624 -1.076 1.62 c -1.215 1.625 -1.354 1.591 -1.474 1.519 c -1.581 1.45 -1.647 1.333 -1.652 1.206 c -2.231 1.206 l -2.227 1.354 -2.185 1.498 -2.108 1.625 c -2.041 1.733 -1.951 1.824 -1.843 1.891 c -1.729 1.96 -1.603 2.007 -1.472 2.032 c -1.329 2.072 -1.183 2.098 -1.036 2.109 c -0.908 2.109 -0.781 2.096 -0.656 2.069 c -0.538 2.044 -0.425 2 -0.321 1.939 c -0.225 1.88 -0.143 1.8 -0.083 1.705 c -0.02 1.599 0.012 1.478 0.008 1.354 c 0.008 0.013 l 0 0 l -0.576 0.728 m -0.674 0.667 -0.785 0.631 -0.9 0.624 c -1.028 0.612 -1.155 0.594 -1.283 0.571 c -1.343 0.561 -1.402 0.547 -1.46 0.528 c -1.515 0.511 -1.566 0.485 -1.612 0.451 c -1.657 0.419 -1.692 0.376 -1.716 0.327 c -1.742 0.267 -1.755 0.203 -1.753 0.138 c -1.755 0.079 -1.735 0.021 -1.697 -0.024 c -1.661 -0.067 -1.615 -0.103 -1.564 -0.127 c -1.509 -0.154 -1.451 -0.171 -1.392 -0.181 c -1.335 -0.19 -1.278 -0.196 -1.222 -0.197 c -1.152 -0.196 -1.083 -0.188 -1.015 -0.173 c -0.94 -0.156 -0.87 -0.127 -0.805 -0.088 c -0.74 -0.048 -0.684 0.004 -0.64 0.066 c -0.594 0.134 -0.571 0.215 -0.574 0.297 c -0.574 0.725 l h f Q q 1 0 0 1 446.6836 732.5762 cm 0 0 m 0.434 0 l 0.434 0.784 l 0.996 0.784 l 0.996 0 l 1.527 0 l 1.527 -0.43 l 0.996 -0.43 l 0.996 -1.822 l 0.993 -1.874 0.993 -1.927 0.996 -1.979 c 1 -2.018 1.011 -2.056 1.031 -2.09 c 1.05 -2.122 1.079 -2.146 1.113 -2.159 c 1.162 -2.177 1.213 -2.185 1.265 -2.183 c 1.387 -2.183 l 1.428 -2.181 1.469 -2.175 1.509 -2.165 c 1.509 -2.608 l 1.323 -2.629 l 1.261 -2.633 1.199 -2.633 1.137 -2.629 c 1.013 -2.633 0.89 -2.619 0.771 -2.587 c 0.688 -2.564 0.613 -2.52 0.553 -2.459 c 0.499 -2.4 0.462 -2.328 0.446 -2.25 c 0.427 -2.155 0.416 -2.059 0.415 -1.963 c 0.415 -0.428 l -0.019 -0.428 l -0.019 0 l 0 0 l f Q q 1 0 0 1 449.0742 731.1235 cm 0 0 m 0 -0.099 0.014 -0.198 0.042 -0.292 c 0.068 -0.382 0.112 -0.466 0.17 -0.54 c 0.229 -0.611 0.303 -0.669 0.388 -0.709 c 0.486 -0.754 0.593 -0.776 0.701 -0.773 c 0.845 -0.78 0.987 -0.742 1.107 -0.664 c 1.216 -0.582 1.296 -0.468 1.336 -0.337 c 1.88 -0.337 l 1.827 -0.603 1.674 -0.838 1.456 -0.996 c 1.349 -1.073 1.231 -1.131 1.105 -1.169 c 0.973 -1.208 0.836 -1.228 0.699 -1.227 c 0.512 -1.23 0.327 -1.196 0.154 -1.126 c 0.003 -1.066 -0.133 -0.973 -0.244 -0.855 c -0.356 -0.73 -0.44 -0.583 -0.491 -0.422 c -0.548 -0.243 -0.576 -0.056 -0.574 0.133 c -0.575 0.313 -0.546 0.493 -0.486 0.664 c -0.426 0.826 -0.336 0.974 -0.221 1.102 c 0.002 1.374 0.334 1.532 0.685 1.535 c 0.877 1.539 1.067 1.495 1.238 1.408 c 1.396 1.326 1.535 1.209 1.644 1.067 c 1.753 0.922 1.833 0.757 1.878 0.582 c 1.927 0.396 1.939 0.203 1.915 0.013 c -0.002 0.013 l 0 0 l 1.341 0.377 m 1.335 0.468 1.315 0.557 1.283 0.643 c 1.253 0.724 1.209 0.798 1.153 0.863 c 1.096 0.926 1.027 0.978 0.951 1.014 c 0.868 1.054 0.777 1.074 0.685 1.073 c 0.594 1.073 0.504 1.055 0.419 1.02 c 0.339 0.986 0.267 0.937 0.207 0.874 c 0.147 0.81 0.099 0.735 0.066 0.653 c 0.031 0.569 0.011 0.479 0.008 0.388 c 1.349 0.388 l h f Q q 1 0 0 1 451.8657 730.7994 cm 0 0 m 0.002 -0.142 0.073 -0.274 0.191 -0.353 c 0.312 -0.423 0.45 -0.458 0.59 -0.454 c 0.651 -0.458 0.711 -0.458 0.773 -0.454 c 0.839 -0.447 0.904 -0.43 0.967 -0.406 c 1.024 -0.385 1.075 -0.349 1.116 -0.303 c 1.155 -0.252 1.174 -0.189 1.168 -0.125 c 1.166 -0.057 1.138 0.008 1.089 0.056 c 1.033 0.107 0.967 0.146 0.895 0.17 c 0.809 0.201 0.72 0.226 0.629 0.245 c 0.329 0.33 l 0.224 0.352 0.121 0.38 0.019 0.415 c -0.076 0.446 -0.166 0.491 -0.247 0.55 c -0.327 0.608 -0.391 0.683 -0.436 0.771 c -0.486 0.873 -0.511 0.986 -0.507 1.1 c -0.512 1.226 -0.475 1.351 -0.404 1.456 c -0.333 1.551 -0.243 1.63 -0.138 1.687 c -0.028 1.747 0.092 1.788 0.215 1.809 c 0.337 1.832 0.462 1.843 0.587 1.843 c 0.716 1.844 0.845 1.83 0.972 1.801 c 1.09 1.774 1.202 1.727 1.304 1.663 c 1.404 1.598 1.488 1.513 1.551 1.413 c 1.621 1.3 1.663 1.173 1.676 1.041 c 1.076 1.041 l 1.059 1.155 0.989 1.253 0.887 1.307 c 0.78 1.355 0.665 1.38 0.547 1.378 c 0.5 1.381 0.452 1.381 0.403 1.378 c 0.35 1.373 0.298 1.36 0.247 1.341 c 0.2 1.325 0.157 1.297 0.122 1.262 c 0.087 1.224 0.069 1.174 0.071 1.124 c 0.069 1.058 0.096 0.995 0.146 0.951 c 0.202 0.903 0.267 0.866 0.337 0.842 c 0.424 0.811 0.512 0.786 0.603 0.768 c 0.917 0.701 l 1.021 0.678 1.124 0.65 1.224 0.616 c 1.319 0.584 1.409 0.539 1.49 0.481 c 1.662 0.359 1.762 0.16 1.755 -0.05 c 1.76 -0.189 1.723 -0.326 1.649 -0.443 c 1.582 -0.551 1.491 -0.642 1.384 -0.709 c 1.267 -0.778 1.14 -0.827 1.007 -0.855 c 0.873 -0.885 0.735 -0.9 0.598 -0.9 c 0.443 -0.902 0.29 -0.883 0.141 -0.845 c 0.01 -0.812 -0.114 -0.753 -0.223 -0.674 c -0.324 -0.601 -0.407 -0.504 -0.465 -0.393 c -0.527 -0.269 -0.559 -0.131 -0.558 0.008 c 0.019 0.008 l 0 0 l f Q 0.146 0.941 0.992 0.044 k q 1 0 0 1 401.2527 729.3892 cm 0 0 m 3.612 2.406 l 3.612 5.296 l 0 5.296 l h f Q 0 0.889 0.676 0 k q 1 0 0 1 404.865 729.3892 cm 0 0 m -3.612 2.406 l -3.612 5.296 l 0 5.296 l h f Q 0.694 0.076 0.209 0 k q 1 0 0 1 403.0589 735.3145 cm 0 0 m -2.2 0 -3.984 -1.784 -3.984 -3.984 c -3.984 -6.184 -2.2 -7.968 0 -7.968 c 2.2 -7.968 3.984 -6.184 3.984 -3.984 c 3.984 -1.784 2.2 0 0 0 c 0 -6.993 m -1.662 -6.993 -3.009 -5.646 -3.009 -3.984 c -3.009 -2.322 -1.662 -0.975 0 -0.975 c 1.662 -0.975 3.009 -2.322 3.009 -3.984 c 3.009 -5.646 1.662 -6.993 0 -6.993 c f Q 0 0.235 0.86 0 k q 1 0 0 1 405.2601 729.2803 cm 0 0 m -1.118 -1.208 -3.015 -1.281 -4.237 -0.159 c -5.159 0.688 -5.459 2.005 -4.999 3.156 c -5.833 3.687 l -6.736 1.681 -5.843 -0.679 -3.836 -1.582 c -2.218 -2.311 -0.312 -1.881 0.836 -0.528 c 0 0 l f Q 0 0 0 0.6 k q 1 0 0 1 397.4813 736.8087 cm 0 0 m -0.238 0 -0.432 -0.193 -0.432 -0.432 c -0.432 -10.524 l -0.432 -10.763 -0.238 -10.956 0 -10.956 c 57.901 -10.956 l 58.139 -10.956 58.333 -10.763 58.333 -10.524 c 58.333 -0.432 l 58.333 -0.193 58.139 0 57.901 0 c h 57.901 -11.155 m 0 -11.155 l -0.348 -11.155 -0.631 -10.872 -0.631 -10.524 c -0.631 -0.432 l -0.631 -0.084 -0.348 0.199 0 0.199 c 57.901 0.199 l 58.249 0.199 58.532 -0.084 58.532 -0.432 c 58.532 -10.524 l 58.532 -10.872 58.249 -11.155 57.901 -11.155 c f Q EMC Q endstream endobj 1387 0 obj <> endobj 1391 0 obj <>stream Adobe Illustrator CS6 (Windows) 2021-04-12T11:45:36+05:00 2021-06-02T10:28:09+05:00 2021-06-02T10:28:09+05:00 1 False False 20.868494 3.999928 Millimeters Cyan Magenta Yellow Black Default Swatch Group 0 C=0 M=24 Y=86 K=0 PROCESS 100.000000 CMYK 0.000000 23.504999 86.022697 0.000000 C=69 M=8 Y=21 K=0 PROCESS 100.000000 CMYK 69.369003 7.635600 20.892700 0.000000 C=0 M=89 Y=68 K=0 PROCESS 100.000000 CMYK 0.000000 88.946404 67.623398 0.000000 C=15 M=94 Y=99 K=4 PROCESS 100.000000 CMYK 14.578501 94.070297 99.160698 4.416000 C=0 M=0 Y=0 K=84 PROCESS 100.000000 CMYK 0.000000 0.000000 0.000000 84.000000 C=0 M=0 Y=0 K=35 PROCESS 100.000000 CMYK 0.000000 0.000000 0.000000 35.000000 C=0 M=0 Y=0 K=60 PROCESS 100.000000 CMYK 0.000000 0.000000 0.000000 60.000004 Document application/pdf proof:pdf xmp.did:804244B35A9BEB118A6FC3C256996E2F uuid:08e30110-bdb7-4606-97ca-63fb62cbcecc uuid:21079f76-f6d7-4329-b725-f2fb35af5114 uuid:722f8893-0b3c-4402-87fb-c713f1fa0e26 uuid:21079f76-f6d7-4329-b725-f2fb35af5114 uuid:21079f76-f6d7-4329-b725-f2fb35af5114 proof:pdf saved xmp.iid:804244B35A9BEB118A6FC3C256996E2F 2021-04-12T11:45:42+05:00 Adobe Illustrator CS6 (Windows) / endstream endobj 1390 0 obj <>/Border[0 0 0]/H/N/Rect[394.85 739.008 458.005 723.67]/Subtype/Link/Type/Annot>> endobj 1392 0 obj <> endobj 1383 0 obj [1393 0 R 1394 0 R 1395 0 R 1396 0 R 1397 0 R 1398 0 R 1399 0 R 1400 0 R 1401 0 R 1402 0 R 1403 0 R 1404 0 R 1405 0 R 1406 0 R 1407 0 R 1408 0 R 1409 0 R 1410 0 R 1411 0 R 1412 0 R 1413 0 R] endobj 1384 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\037)31(\025\007\025\002\016\n)-10(\026)11(\013\007\216\001\020\203 \002\013\n \220\022\f\016\002\016\024\016\001\001\ \025\006)-10(\026\216)]TJ 47.216 0 Td [(Color)31(ectal cancer and pr)31(egnancy)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0.062 Tw 8 0 0 8 42.5197 731.2159 Tm (15.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(S)-24(chaefer)]TJ /Span<>> BDC ( )Tj EMC [(C, P)30(e)-12(ter)-9.9(s)]TJ /Span<>> BDC ( )Tj EMC [(PW)31(J, Miller)]TJ /Span<>> BDC ( )Tj EMC [(RK, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Dr)-22(ugs dur)-37(ing p)25(r)-24(egnancy )]TJ 0.26 Tw -1.796 -1.25 Td [(and l)-16(a)-17(c)-16(t)15.1(a)14.9(t)-31.9(ion: tr)-24(ea)15(tment )0.5(opt)-32(ions and r)-37(isk )0.5(assess)26(ment. A)-25(cademic )]TJ 0.023 Tw 0 -1.25 TD [(P)35(r)-24(ess, 2014.)]TJ 0.197 Tw T* (16.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Na)15(t)-32(ional T)45(o)14(xicol)30.1(o)-16(g)16(y P)35.1(r)-32(o)-16(gr)-33(am. NTP M)-24(ono)-16(gr)-32.9(aph: Devel)30(opment)15(al )]TJ 0.018 Tc 0.659 Tw -1.796 -1.25 Td [(Ef)-56.1(fec)-16.1(ts )0.6(and )0.5(P)34.9(r)-24.1(egnancy )0.5(Outcomes )0.5(Asso)-16.2(c)-24.1(ia)14.9(ted )0.5(W)-16.1(i)-24.1(t)-13.1(h )0.6(Cancer)18.1( )]TJ 0.019 Tc 0.669 Tw T* [(C)0.5(h)0.6(e)0.5(m)0.6(o)17.5(t)-12.5(h)0.6(e)0.5(r)-32.4(a)0.5(p)0.5(y)0.6( U)0.5(s)0.5(e)0.6( D)0.5(u)0.6(r)-36.5(i)0.6(n)0.5(g)0.5( P)35.6(r)-23.5(e)0.5(g)0.6(n)0.5(a)0.5(n)0.6(c)0.5(y)0.6(.)0.5( N)0.5(T)0.6(P)0.5( M)-23.4(o)0.5(n)0.5(o)-15.4(g)0.5(r)0.6(.)0.5( 2)0.5(0)0.6(1)0.5(3)19( )]TJ 0 Tc 0.023 Tw T* [(Ma)15(y;\(2\):i-214. PMID: 24736875.)]TJ 0.169 Tw T* (17.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(\224\035\024\022\f\026\021\017\027 )0.5(\(\024\022\f\026\035\017\023\035\026\021\017\027\). )0.6(\221\026\027\024\235\017-\202\r\036\027\021\017\f. )0.6(2011. )0.5(\212\024\f\021\031\023\027\024 )]TJ 0.025 Tc 0.889 Tw -1.796 -1.25 Td (\023\024)Tj /Span<>> BDC ( )Tj EMC [(\026\007\030\036\f\031 ht)-29.7(tp://www.a)-16.7(ccessd)42.3(a)15.3(t)15.2(a.fd)42.3(a.gov/dr)-21.7(ugsa)15.3(tfd)42.3(a_d)-15.7(o)-15.8(cs/)]TJ 0 Tc 0.02 Tw T* [(l)-16(abel/2011/021759s012lbl.pdf. \215\024)]TJ /Span<>> BDC ( )Tj EMC (\f\024\f\021\024\016\027\017\033 \027\026)Tj /Span<>> BDC ( )Tj EMC (17 \026\r\020\031\f\021\026 2015 \020. )Tj 0.145 Tw T* [(/ El)30(o)14(x)-11(a)15(t)-32(in \(o)14(x)-11(al)-31(ipl)-15.9(a)15(t)-32(in\). Sanof)-28(i-A)15(vent)-32(is. 2011. ht)-30(tp://www.a)-16.9(ccess)]TJ 0 Tw (-)Tj 0.006 Tc 0.35 Tw T* [(d)41.9(a)15(t)15(a.fd)42(a.gov/dr)-22(ugsa)15(tfd)42(a_d)-16.1(o)-16(cs/l)-16.1(abel/2011/021759s012lbl.pdf. )0.5(17)]TJ 0 Tc 0 Tw 4.664 0 0 4.664 259.471 623.8799 Tm [(t)-19(h )]TJ 0.023 Tw 8 0 0 8 42.5197 611.2159 Tm [(A)10(ugust , 2015. \(in Russ.\).)]TJ 0.013 Tc 0.475 Tw T* (18.)Tj /Span<>> BDC ( )Tj EMC 1.848 0 Td (Jeong)Tj /Span<>> BDC ( )Tj EMC (H, Choi)Tj /Span<>> BDC ( )Tj EMC [(S, S)-15.9(ong)]TJ /Span<>> BDC ( )Tj EMC [(JW, e)-11.9(t)]TJ /Span<>> BDC ( )Tj EMC [(al. R)13.1(egul)-15.9(a)15.1(t)-31.9(ion of UDP-)]TJ 0 Tc 0.134 Tw -1.848 -1.25 Td [(gl)35(ucur)-32(onosyl)56.1(tr)-33(ansfer)-32.9(ase \(UG)-12(T\) 1A1 b)12(y p)25(r)-32(o)-16(gester)-31.9(one and i)-24(ts im)10(p)32(a)-17(c)-16(t )]TJ 0.012 Tc 0.453 Tw T* [(on l)-16.2(abe)-12.2(t)14.7(al)29.8(ol el)-31.2(imina)14.7(t)-32.2(ion. )]TJ /T1_2 1 Tf -0.012 Tw [(X)17.7(enobio)12.7(tica)]TJ /T1_1 1 Tf 0.453 Tw [(. 2008 Jan;38\(1\):62\22675.)12( )]TJ 0.017 Tc -0.017 Tw T* [(d)-15.6(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 2.513 0 Td (10.1080/00498250701744633)Tj 0 0 0 1 k /GS1 gs 0.606 Tw [( PMID: 18098064; PMCID:)17( )]TJ 0 Tc 0 Tw -2.513 -1.25 Td (PMC3691104.)Tj 0.001 Tc 0.349 Tw T* (19.)Tj /Span<>> BDC ( )Tj EMC 1.799 0 Td [(\025\026\n\023\021\024\f\026\030 \(\017\030\017\027\024\021\036\022\026\027\ \). Phar)-15.8(ma)-16.8(c)-23.8(ia and U)13.2(pjohn Co., 2014)1( )]TJ 0 Tc 0.295 Tw -1.799 -1.25 Td [(\020. \212\024\f\021\031\023\027\024 \023\024 \026\007\030\036\f\031 ht)-30(tp://l)-15.9(abel)-31(ing.pf)-28(izer.com/S)-15.9(ho)-14(wL)-32(abel)-30.9(ing.)]TJ 0.022 Tw T* (aspx?id=533. \215\024)Tj /Span<>> BDC ( )Tj EMC (\f\024\f\021\024\016\027\017\033 \027\026)Tj /Span<>> BDC ( )Tj EMC [(31 \n\026\016 2015 \020. / K)-16(am)10(pt)17.1(osar \(ir)-37(ino)17(te)]TJ 0 Tw (-)Tj 0.075 Tw T* [(can\). Phar)-16(ma)-17(c)-24(ia and U)13(pjohn Co., 2014 A)15(v)-15(ail)-16(able a)15(t ht)-30(tp://l)-16(abel)-30.9(ing.)]TJ 0.023 Tw T* [(pf)-28(izer.com/S)-15.9(ho)-14(wL)-32(abel)-30.9(ing.aspx?id=533 31)]TJ 0 Tw 4.664 0 0 4.664 179.8745 513.8799 Tm [(t)-13(h )]TJ 0.023 Tw 8 0 0 8 185.1927 511.2159 Tm [(Ma)15(y, 2015. \(in Russ.\).)]TJ 0.098 Tw -17.834 -1.25 Td (20.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Zhao)Tj /Span<>> BDC ( )Tj EMC [(Y, Heber)-22(t)]TJ /Span<>> BDC ( )Tj EMC [(MF, V)30.1(enk)-17(a)15(t)15(ar)-33(amanan)]TJ /Span<>> BDC ( )Tj EMC [(R. Basic obste)-12(tr)-36.9(ic phar)-16(ma)]TJ 0 Tw (-)Tj -1.796 -1.25 Td [(col)30(o)-16(g)16(y. )]TJ /T1_2 1 Tf 0.247 Tw 3.387 0 Td [(Semin P)15(er)-37(inatol.)]TJ /T1_1 1 Tf [( 2014 Dec;38\(8\):475\22686. d)-15.9(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1053/j.)Tj -3.387 -1.25 Td [(sem)10(per)-37(i.2014.08.011)]TJ 0 0 0 1 k /GS1 gs 0.241 Tw [( Epub 2014 O)-16(c)-16(t 1. PMID: 25281357; PMCID: )]TJ 0 Tw T* (PMC5771662.)Tj 0.034 Tw T* (21.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(P)30(er)-24(eir)-32.9(a)]TJ /Span<>> BDC ( )Tj EMC [(RD, De L)35(ong)]TJ /Span<>> BDC ( )Tj EMC [(NE, W)12(ang)]TJ /Span<>> BDC ( )Tj EMC [(RC, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Angio)-16(genesis in t)-12.9(he pl)-16(a)]TJ 0 Tw (-)Tj 0.017 Tw -1.796 -1.25 Td [(cent)15(a: t)-13(he r)-32(ole of r)-24(ea)-17(c)-16(t)-31.9(i)-16(ve o)14(xygen spec)-24(ies signal)-31(ing. )]TJ /T1_2 1 Tf [(Biomed )0.5(R)21(es Int)]TJ /T1_1 1 Tf 0 Tw (. )Tj 0.139 Tw T* [(2015;2015:814543. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1155/2015/814543)Tj 0 0 0 1 k /GS1 gs 0.139 Tw ( Epub 2015 Jan 29. )Tj 0.023 Tw T* (PMID: 25705690; PMCID: PMC4325211.)Tj 0.166 Tw T* (22.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(L)-32(ar)-32(ge)]TJ /Span<>> BDC ( )Tj EMC [(MJ, W)22(e)-12(tend)-16(or)-23.9(f)]TJ /Span<>> BDC ( )Tj EMC [(M, L)-32(anz)]TJ /Span<>> BDC ( )Tj EMC [(RB, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. T)47(he epider)-16(mal gr)-32(o)-14(w)-23.9(t)-13(h )]TJ -0.011 Tw -1.796 -1.25 Td [(f)16(a)-17(c)-16(t)17(or )0.6(r)-24(ecept)17(or )0.6(cr)-37(i)-24(t)-32(icall)35(y )0.6(r)-24(egul)-16(a)15(tes )0.6(end)-16(ome)-12(tr)-36.9(ial )0.5(func)-16(t)-31.9(ion )0.5(dur)-37(ing )0.6(ear)-30(l)35(y )]TJ 0 Tw T* [(p)25(r)-24(egnancy)]TJ /T1_2 1 Tf 0.028 Tw (. PLoS Genet)Tj /T1_1 1 Tf [(. 2014 Jun 19;10\(6\):e1004451. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1371/)Tj T* [(jour)-15(nal.pgen.1004451)]TJ 0 0 0 1 k /GS1 gs 0.023 Tw ( PMID: 24945252; PMCID: PMC4063709.)Tj 0.238 Tw T* (23.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(L)-32(ieu)]TJ /Span<>> BDC ( )Tj EMC [(CH, R)13(enfr)-32(o)]TJ /Span<>> BDC ( )Tj EMC [(L)-35(A, de G)20(r)-33(amont)]TJ /Span<>> BDC ( )Tj EMC [(A, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Aide e)-12(t R)13(echer)-32(che )]TJ 0.345 Tw -1.796 -1.25 Td [(en Canc\351r)-32(ol)30(o)-16(gie Digest)-31.9(i)-16(ve F)10(ound)42(a)15(t)-32(ion. Asso)-16(c)-23.9(ia)15(t)-32(ion of a)-17(ge wi)-24(t)-13(h )]TJ 0.01 Tc 0.372 Tw T* [(sur)-32(v)-15.9(i)-16(v)-14.9(al in p)32(a)15.1(t)-32(ients wi)-23.9(t)-12.9(h me)-11.9(t)15(ast)15(a)15.1(t)-32(ic col)30.1(or)-23.9(ec)-15.9(t)15(al cancer: anal)35.1(y)]TJ 0 Tc 0 Tw 27.286 0 Td (-)Tj 0.322 Tw -27.286 -1.25 Td [(sis fr)-32(om t)-13(he ARC)20(AD Cl)-31(inical T)50(r)-37(ials P)35(r)-32(o)-16(gr)-33(am. )]TJ /T1_2 1 Tf (J Clin Oncol. )Tj /T1_1 1 Tf 0 Tw (2014 )Tj 0.01 Tc 0.36 Tw T* [(Sep 20;32\(27\):2975\22684. d)-15.6(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs -0.01 Tw [(10.1200/JC)13.3(O.2013.54.9329)]TJ 0 0 0 1 k /GS1 gs 0.36 Tw [( PMID:)10( )]TJ 0 Tc 0.023 Tw T* (25002720; PMCID: PMC4809210.)Tj -0.018 Tw T* (24.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Ma)15(tsui)]TJ /Span<>> BDC ( )Tj EMC [(DM. T)47(her)-33(apeut)-31.9(ic dr)-22(ug moni)-24(t)17(or)-37(ing in p)25(r)-24(egnancy. )]TJ /T1_2 1 Tf (Ther Drug )Tj 0 Tw -1.796 -1.25 Td (Monit)Tj /T1_1 1 Tf -0.09 Tw [(. 2012 O)-16(c)-16(t;34\(5\):507\22611. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1097/FTD.0b013e318261c372)Tj 0 0 0 1 k /GS1 gs ( )Tj 0.023 Tw T* (PMID: 22846897)Tj 0.013 Tc 0.469 Tw T* (25.)Tj /Span<>> BDC ( )Tj EMC 1.847 0 Td (Jones)Tj /Span<>> BDC ( )Tj EMC [(A, P)10.3(ovl)30.3(o)-13.7(w)]TJ /Span<>> BDC ( )Tj EMC [(MR. Col)30.2(or)-23.7(ec)-15.7(t)15.2(al Cancer P)35.2(r)-23.7(esent)-31.7(ing wi)-23.7(t)-12.7(h)13( )]TJ 0 Tc 0.268 Tw -1.847 -1.25 Td [(Const)-32(ip)32(a)15(t)-32(ion Dur)-37(ing P)35.1(r)-24(egnancy. )]TJ /T1_2 1 Tf 0 Tw (Cureus)Tj /T1_1 1 Tf 0.268 Tw [(. 2017 Ap)25.1(r 25;9\(4\):e1190. )]TJ 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td [(10.7759/cur)-23.9(eus.1190)]TJ 0 0 0 1 k /GS1 gs 0.023 Tw ( PMID: 28553568; PMCID: PMC5444916.)Tj 0.03 Tw 27.208 57.5 Td (26.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Ar)-33(aujo)]TJ /Span<>> BDC ( )Tj EMC [(L, R)13(ebic)]TJ /Span<>> BDC ( )Tj EMC (N, Dau)Tj /Span<>> BDC ( )Tj EMC [(H, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. R)13(ep)25(r)-32(oduc)-16(t)-32(i)-15.9(ve Heal)56(t)-13(h E)35(xper)-37(iences )]TJ 0.089 Tw -1.796 -1.25 Td [(of F)10(emales Dia)-17(gnosed wi)-24(t)-13(h Y)40(oung-Onse)-12(t Col)30.1(or)-24(ec)-16(t)15(al Cancer: A Mul)56(t)-32(i-)]TJ 0.055 Tw T* [(Me)-12(t)-13(hod Cr)-32(oss-Sec)-15.9(t)-32(ional Sur)-32(ve)-11(y. )]TJ /T1_2 1 Tf [(Cur)-15.9(r Oncol)]TJ /T1_1 1 Tf (. 2022 Jan 21;29\(2\):465\226)Tj 0.003 Tc 0.349 Tw T* [(478. d)-15.7(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs -0.003 Tw [(10.3390/cur)-23.7(r)-31.8(oncol29020042)]TJ 0 0 0 1 k /GS1 gs 0.349 Tw [( PMID: 35200542; PMCID:)3( )]TJ 0 Tc 0 Tw T* (PMC8870126.)Tj 0.036 Tw T* (27.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Dau)Tj /Span<>> BDC ( )Tj EMC 1.806 0 Td [(H, Saad )0.5(El )0.5(Din)]TJ /Span<>> BDC ( )Tj EMC [(K, McT)40.1(a)-17(ggar)-22(t-Co)-14(w)-12(an)]TJ /Span<>> BDC ( )Tj EMC 14.209 0 Td [(H, e)-11.9(t)]TJ /Span<>> BDC ( )Tj EMC [(al. )0.5(Heal)56(t)-13(h )0.5(infor)-16(ma)]TJ 0 Tw (-)Tj -0.056 Tw -17.811 -1.25 Td [(t)-32(ion seek)-15.9(ing behav)-16(ior)-9.9(s among indi)-15.9(v)-16(iduals wi)-24(t)-13(h young-onse)-11.9(t and aver)]TJ 0 Tw 27.286 0 Td (-)Tj -0.01 Tw -27.286 -1.25 Td [(a)-17(ge-onse)-12(t col)30(or)-23.9(ec)-16(t)15(al cancer: an inter)-14.9(na)15(t)-32(ional cr)-32(oss-sec)-16(t)-31.9(ional sur)-31.9(ve)-11(y. )]TJ /T1_2 1 Tf 0.273 Tw T* [(Suppor)-40(t )0.5(Care )0.6(Cancer)]TJ /T1_1 1 Tf [(. )0.5(2020 )0.5(Dec;28\(12\):6011\2266021. )0.5(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw 23.899 0 Td (10.1007/)Tj -23.899 -1.25 Td (s00520-020-05446-5)Tj 0 0 0 1 k /GS1 gs 0.023 Tw [( Epub 2020 Ap)25(r 15. PMID: 32296980.)]TJ 0.143 Tw T* (28.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Gar)-32(g)]TJ /Span<>> BDC ( )Tj EMC (R, Cheng)Tj /Span<>> BDC ( )Tj EMC [(V, Ell)-31(is)]TJ /Span<>> BDC ( )Tj EMC [(U, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Dir)-23.9(ec)-16(t medical costs of young-)]TJ 0.068 Tw -1.796 -1.25 Td [(onse)-12(t col)30(or)-24(ec)-16(t)15(al cancer: a w)-14(or)-30(ld)-16.9(wide sy)-13(stema)15(t)-32(ic r)-23.9(ev)-16(iew. )]TJ /T1_2 1 Tf (BMC Health )Tj -0.002 Tw T* [(Ser)-42(v R)21(es.)]TJ /T1_1 1 Tf [( 2022 A)10(ug 30;22\(1\):1100. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1186/s12913-022-08481-)Tj T* (6)Tj 0 0 0 1 k /GS1 gs 0.023 Tw ( PMID: 36042470; PMCID: PMC9426038.)Tj 0.107 Tw T* (29.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Y)35(unusov)-15(a)]TJ /Span<>> BDC ( )Tj EMC [(N.V., K)25(ond)42(akov)-14.9(a)]TJ /Span<>> BDC ( )Tj EMC [(I.V., K)25(ol)30(omie)-11.9(ts)]TJ /Span<>> BDC ( )Tj EMC [(L.A., e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. M)-24(olecul)-16(ar )]TJ 0.204 Tw -1.796 -1.25 Td [(t)15(ar)-32(ge)-12(ts for t)-12.9(he t)-13(her)-32.9(apy of cancer asso)-15.9(c)-24(ia)15(ted wi)-23.9(t)-13(h me)-11.9(t)15(abol)-31(ic syn)]TJ 0 Tw (-)Tj 0.227 Tw T* [(dr)-32(ome \(tr)-33(anscr)-37(ipt)-32(ion and gr)-32(o)-14(w)-23.9(t)-13(h f)16(a)-17(c)-16(t)17(or)-9.9(s\). )]TJ /T1_2 1 Tf [(Asia-P)18(acif)-42.9(ic Jour)-13.9(nal of )]TJ 0.002 Tc 0.349 Tw T* (Clinical Oncology)Tj /T1_1 1 Tf [(. 2018;14\(3\):134\226140. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs -0.002 Tw (10.1111/ajco.12780)Tj 0 0 0 1 k /GS1 gs 0 Tc 0 Tw 27.638 0 Td ( )Tj 0.023 Tw -27.638 -1.25 Td [(EDN ZZX)16.1(GUH.)]TJ 0.003 Tc 0.35 Tw T* (30.)Tj /Span<>> BDC ( )Tj EMC 1.808 0 Td (\223\036\030\027\t\001\024\r\026)Tj /Span<>> BDC ( )Tj EMC 5.391 0 Td [(\202.\214., )0.5(\025\024\035\024\n\017\036\006)]TJ /Span<>> BDC ( )Tj EMC 7.223 0 Td [(\214.\202., )0.5(\221\017\027\017\035\022\017\027)]TJ /Span<>> BDC ( )Tj EMC (\222.\206., \017)Tj /Span<>> BDC ( )Tj EMC 10.65 0 Td [(\f\024\026\r\021.)3( )]TJ 0 Tc 0.087 Tw -25.072 -1.25 Td (\210\023\021\017\n\017\026\006\017\016 \023\024\007\b\024\007\024\r \022\ )Tj /Span<>> BDC ( )Tj EMC (\r\t\002\024\030\031 \024\002\255\036\n\026 \b\017\030\031\030\020\017\004\ \036\f\022\024\020\024 \035\036\004\036\027\017\016 )Tj 0.005 Tc 0.349 Tw T* (\031)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\034\027\t\b \030\026\022\024\n \001\036\005\022\017 \n\026\021\ \022\017 \(\030\024\035\034 \017\f\f\035\036\007\024\r\026\027\017\016 \f\ \021\024\030\024\032\036)Tj 0 Tc 0 Tw (-)Tj 0.163 Tw T* (\r\t\b \035\017\n\235\024\031\035\024\r\). )Tj /T1_2 1 Tf (\216\n\033\032\n\t\020 \n\021\013\n\023\n\202\025\025.)Tj /T1_1 1 Tf ( 2016;62\(6\):807\226811. EDN )Tj 0.294 Tw T* [(XEPBZV. )0.5(/ Cher)-15(ny)-12.9(shov)-15(a)]TJ /Span<>> BDC ( )Tj EMC [(A.L., )0.5(K)25(ol)30(omie)-12(ts)]TJ /Span<>> BDC ( )Tj EMC 17.144 0 Td [(L.A., )0.5(S)-16(inilk)-16(in)]TJ /Span<>> BDC ( )Tj EMC 5.904 0 Td [(I.G., )0.5(e)-12(t)]TJ /Span<>> BDC ( )Tj EMC (al. )Tj 0.109 Tw -23.048 -1.25 Td [(Opt)-32(imiza)15.1(t)-32(ion of app)25(r)-31.9(oa)-17(ches t)17(o t)-12.9(he choice of t)-12.9(he objec)-16(t of sur)-32(gical )]TJ 0.081 Tw T* [(tr)-24(ea)15(tment )0.5(in p)32(a)15(t)-32(ients )0.5(wi)-24(t)-12.9(h cer)-32(v)-16(ical )0.5(cancer \(t)-12.9(he r)-32(ole )0.5(of t)-13(he )0.5(stud)17(y of )]TJ 0.073 Tw T* [(sent)-32(inel )0.5(l)35(ym)10(ph )0.5(nodes\). )]TJ /T1_2 1 Tf 9.641 0 Td [(Questions )0.6(of )0.5(oncology.)]TJ /T1_1 1 Tf [( )0.5(2016;62\(6\):807\226811. )]TJ 0.023 Tw -9.641 -1.25 Td (EDN XEPBZV. \(in Russ.\).)Tj 0.011 Tc 0.411 Tw T* (31.)Tj /Span<>> BDC ( )Tj EMC 1.84 0 Td (\202\002\031\026\030\024\r\026)Tj /Span<>> BDC ( )Tj EMC 5.088 0 Td [(\206.\217., )0.5(\202\035\036\027\021\024\r)]TJ /Span<>> BDC ( )Tj EMC 6.526 0 Td [(\222.\222., )0.5(\202\027\023\017\035\024\020\024\r)]TJ /Span<>> BDC ( )Tj EMC 7.896 0 Td [(\221.\200., )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 3.683 0 Td [(\f\024\026\r\021.)11( )]TJ 0.006 Tc 0.349 Tw -25.033 -1.25 Td [(\210\027\022\024\020\017\027\036\022\024\035\024\020\017\016: \203\026\006\ \017\024\027\026\035\034\027\024\036 \030\031\022\024\r\024\007\f\021\r\024\ \(\215\024\007 \030\036\007\026\022\006\017\036\005)6( )]TJ 0 Tc 0.19 Tw T* (\025\026\023\030\017\027\026)Tj /Span<>> BDC ( )Tj EMC (\202.\212., \202\001\030\026\235\016\027\026)Tj /Span<>> BDC ( )Tj EMC (\214.\202., \221\021\017\035\017\007\017)Tj /Span<>> BDC ( )Tj EMC (\222.\221.\). \204\024\f\022\r\026: \210\002\013\036\f\021\r\024 )Tj 0.114 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\024\020\030\026\027\017\004\036\027\027\024\005 \024\021\r\036\021\f\021\ \r\036\027\027\024\f\021\034\033 \222\007\026\021\036\035\034\f\022\026\ \016 \020\030\031\023\023\026 \253\206\224\210\230\202\217-)Tj 0.286 Tw T* (\204\036\007\017\026\273. 2019; 384 \f. \(\203\026\006\017\024\027\026\035\ \034\027\t\036 \030\031\022\024\r\024\007\f\021\r\026\). ISBN 978-)Tj 0.021 Tc 0.774 Tw T* [(5-9704-5329-2. d)-16.4(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs -0.021 Tw (10.33029/9704-5329-2-ONR-2019-1-384)Tj 0 0 0 1 k /GS1 gs 0 Tc 0 Tw 27.638 0 Td ( )Tj 0.17 Tw -27.638 -1.25 Td [(EDN RCNLIG. / A)-14(buzar)-31.9(ov)-15(a)]TJ /Span<>> BDC ( )Tj EMC [(G.R., Alent)17(ov)]TJ /Span<>> BDC ( )Tj EMC [(I.I., An)11(pil)30.1(o)-16(gov)]TJ /Span<>> BDC ( )Tj EMC [(S.V., e)-12(t)]TJ /Span<>> BDC ( )Tj EMC (al. )Tj -0.125 Tw T* [(Onco)-16(g)16(ynecol)30(o)-16(g)16(y: Na)15(t)-32(ional Guide \(Edi)-23.9(ted b)12(y K)-16(apl)-30.9(in)]TJ /Span<>> BDC ( )Tj EMC [(A.D., Ashr)-33(af)-34(y)22(an)]TJ /Span<>> BDC ( )Tj EMC (L.A., )Tj 0.222 Tw T* [(S)15(t)-32(il)-31(idi)]TJ /Span<>> BDC ( )Tj EMC [(I.S.\) M)-24(osco)-13.9(w: L)-32(imi)-24(ted L)-32(iabil)-31(i)-23.9(t)-10(y Com)10(p)32(any P)20.1(ubl)-31(ishing G)20(r)-32(oup )]TJ 0.309 Tw T* [(\231GEOT)35(AR-Media\232, 2019.)]TJ /Span<>> BDC ( )Tj EMC (\227 384 p.)Tj /Span<>> BDC ( )Tj EMC [(\227 \(Na)15(t)-31.9(ional Guidel)-30.9(ines\). \(in )]TJ 0.084 Tw T* [(Russ.\). ISBN 978-5-9704-5329-2. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.33029/9704-5329-2-ONR-)Tj T* (2019-1-384.)Tj 0 0 0 1 k /GS1 gs 0.023 Tw ( EDN RKNLIG.)Tj 0.041 Tw T* (32.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(V)30(enugop)32(al)]TJ /Span<>> BDC ( )Tj EMC [(A, S)15(t)17.1(of)-56(fel)]TJ /Span<>> BDC ( )Tj EMC [(EM. Col)30(or)-23.9(ec)-16(t)15(al Cancer in Y)40(oung A)15.1(dul)56(ts. )]TJ /T1_2 1 Tf 0 Tw [(Cur)-15.9(r )]TJ 0.222 Tw -1.796 -1.25 Td [(T)56(reat )0.5(Op)13(tions Gastroenterol)]TJ /T1_1 1 Tf [(. )0.5(2019 Mar;17\(1\):89\22698. )0.5(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw 23.899 0 Td (10.1007/)Tj -23.899 -1.25 Td (s11938-019-00219-4)Tj 0 0 0 1 k /GS1 gs 0.023 Tw ( PMID: 30712157.)Tj 0.003 Tw T* (33.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Connell)Tj /Span<>> BDC ( )Tj EMC [(L)35(C, M)-24(o)17(t)15(a)]TJ /Span<>> BDC ( )Tj EMC [(JM, Br)-33(a)-17(ghir)-32(ol)-31(i)]TJ /Span<>> BDC ( )Tj EMC [(MI, e)-11.9(t)]TJ /Span<>> BDC ( )Tj EMC [(al. T)47(he R)-24(ising Inc)-24(idence of )]TJ -0.014 Tw -1.796 -1.25 Td [(Y)40(ounger P)40(a)15(t)-32(ients W)-15.9(i)-24(t)-13(h Col)30(or)-23.9(ec)-16(t)15(al Cancer: Q)-16(uest)-32(ions A)-13.9(bout S)-24(cr)-24(eening, )]TJ 0.041 Tw T* [(Biol)30(o)-16(g)16(y, and T)49.9(r)-23.9(ea)15(tment. )]TJ /T1_2 1 Tf [(Cur)-16(r T)56(reat Op)13(tions Oncol)]TJ /T1_1 1 Tf [(. 2017 Ap)25.1(r;18\(4\):23. )]TJ 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1007/s11864-017-0463-3)Tj 0 0 0 1 k /GS1 gs 0.023 Tw ( PMID: 28391421.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 0 Tw 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\033\030\031\030\213\b)-20.9(\035\231\213\233\t \021\032)50(\b)42(\032\231\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj /T1_3 1 Tf 25 0 0 25 505.552 56.0378 Tm (107)Tj ET endstream endobj 1393 0 obj <>/Border[0 0 0]/H/N/Rect[62.6259 578.512 163.867 569.216]/Subtype/Link/Type/Annot>> endobj 1394 0 obj <>/Border[0 0 0]/H/N/Rect[229.11 498.512 263.622 489.056]/Subtype/Link/Type/Annot>> endobj 1395 0 obj <>/Border[0 0 0]/H/N/Rect[42.5197 488.512 110.959 479.216]/Subtype/Link/Type/Annot>> endobj 1396 0 obj <>/Border[0 0 0]/H/N/Rect[124.418 448.512 197.874 439.216]/Subtype/Link/Type/Annot>> endobj 1397 0 obj <>/Border[0 0 0]/H/N/Rect[233.71 408.512 263.622 399.056]/Subtype/Link/Type/Annot>> endobj 1398 0 obj <>/Border[0 0 0]/H/N/Rect[42.5197 398.512 114.103 389.216]/Subtype/Link/Type/Annot>> endobj 1399 0 obj <>/Border[0 0 0]/H/N/Rect[148.702 348.512 239.256 339.216]/Subtype/Link/Type/Annot>> endobj 1400 0 obj <>/Border[0 0 0]/H/N/Rect[156.566 318.512 263.622 309.056]/Subtype/Link/Type/Annot>> endobj 1401 0 obj <>/Border[0 0 0]/H/N/Rect[57.2978 278.512 126.921 269.216]/Subtype/Link/Type/Annot>> endobj 1402 0 obj <>/Border[0 0 0]/H/N/Rect[311.597 708.512 404.91 699.216]/Subtype/Link/Type/Annot>> endobj 1403 0 obj <>/Border[0 0 0]/H/N/Rect[466.151 658.512 496.063 649.056]/Subtype/Link/Type/Annot>> endobj 1404 0 obj <>/Border[0 0 0]/H/N/Rect[274.961 648.512 342.52 639.216]/Subtype/Link/Type/Annot>> endobj 1405 0 obj <>/Border[0 0 0]/H/N/Rect[402.591 618.512 496.063 609.056]/Subtype/Link/Type/Annot>> endobj 1406 0 obj <>/Border[0 0 0]/H/N/Rect[274.961 608.512 278.961 599.216]/Subtype/Link/Type/Annot>> endobj 1407 0 obj <>/Border[0 0 0]/H/N/Rect[430.083 568.512 496.063 559.056]/Subtype/Link/Type/Annot>> endobj 1408 0 obj <>/Border[0 0 0]/H/N/Rect[358.047 408.512 496.063 399.216]/Subtype/Link/Type/Annot>> endobj 1409 0 obj <>/Border[0 0 0]/H/N/Rect[401.512 358.512 496.063 349.216]/Subtype/Link/Type/Annot>> endobj 1410 0 obj <>/Border[0 0 0]/H/N/Rect[274.961 348.512 314.96 339.216]/Subtype/Link/Type/Annot>> endobj 1411 0 obj <>/Border[0 0 0]/H/N/Rect[466.151 328.512 496.063 319.056]/Subtype/Link/Type/Annot>> endobj 1412 0 obj <>/Border[0 0 0]/H/N/Rect[274.961 318.512 342.52 309.216]/Subtype/Link/Type/Annot>> endobj 1413 0 obj <>/Border[0 0 0]/H/N/Rect[289.739 278.512 383.21 269.216]/Subtype/Link/Type/Annot>> endobj 1434 0 obj <> endobj 1433 0 obj <> endobj 1432 0 obj <> endobj 1431 0 obj <> endobj 1430 0 obj <> endobj 1429 0 obj <> endobj 1428 0 obj <> endobj 1427 0 obj <> endobj 1426 0 obj <> endobj 1425 0 obj <> endobj 1424 0 obj <> endobj 1423 0 obj <> endobj 1422 0 obj <> endobj 1421 0 obj <> endobj 1420 0 obj <> endobj 1419 0 obj <> endobj 1418 0 obj <> endobj 1417 0 obj <> endobj 1416 0 obj <> endobj 1415 0 obj <> endobj 1414 0 obj <> endobj 1381 0 obj [1435 0 R 1436 0 R 1437 0 R 1438 0 R 1439 0 R 1440 0 R 1441 0 R 1442 0 R 1443 0 R 1444 0 R 1445 0 R 1446 0 R 1447 0 R 1448 0 R] endobj 1382 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.023 Tw 10 0 0 10 70.8661 724.8299 Tm (\255\026\036\031\036\025\034\224 \017\225 \032\026\020\017\022\032\221 \(\ ORCID\))Tj /T1_1 1 Tf 0.103 Tw 0 -1.218 TD (\223\036\030\027\t\001\024\r\026 \202\035\036\027\026 \214\036\024\027\017\ \007\024\r\027\026)Tj /Span<>> BDC ( )Tj EMC (\227 \007.\n.\027., \023\030\024\235\036\f\f\024\030 )Tj 0.049 Tw T* (\217\202\203, \r\036\007\031\013\017\005 \027\026\031\004\027\t\005 \f\024\ \021\030\031\007\027\017\022 \024\021\007\036\035\036\027\017\016 \020\017\ \027\036\022\024)Tj 0 Tw (-)Tj 0.221 Tw T* (\035\024\020\017\017, \203\026\031\004\027\024-\017\f\f\035\036\007\024\r\ \026\021\036\035\034\f\022\017\005 \017\027\f\021\017\021\031\021 \024\027\ \022\024\035\024)Tj 0 Tw (-)Tj 0.184 Tw T* (\020\017\017, \230\024\n\f\022\017\005 \027\026\006\017\024\027\026\035\034\ \027\t\005 \017\f\f\035\036\007\024\r\026\021\036\035\034\f\022\017\005 \ \n\036)Tj 0 Tw (-)Tj 0.067 Tw T* (\007\017\006\017\027\f\022\017\005 \006\036\027\021\030 \217\024\f\f\017\ \005\f\022\024\005 \026\022\026\007\036\n\017\017 \027\026\031\022; ORCI\ D: )Tj 0 Tw 0 -1.218 TD (0000-0002-8194-2811.)Tj 0.222 Tw 0 -1.218 TD (\204\026\030\022\024\r\017\004 \200\017\021\026\035\017\005 \202\035\036\ \022\f\026\027\007\030\024\r\017\004)Tj /Span<>> BDC ( )Tj EMC (\227 \n\035\026\007\001\017\005 \027\026)Tj 0 Tw (-)Tj 0.13 Tw T* [(\031\004\027\t\005 \f\024\021\030\031\007\027\017\022 \024\021\007\036\035\ \036\027\017\016 )0.5(\021\024\030\026\022\026\035\034\027\024\005 \024\027\022\024\035\024\020\ \017\017 )]TJ 0.043 Tw T* [(\203\222\222 )0.5(\024\027\022\024\035\024\020\017\017, )0.5(\203\026\031\004\027\024-\017\f\f\035\036\007\024\r\026\021\036\035\034\f\ \022\017\005 )0.7(\017\027\f\021\017\021\031\021 )]TJ 0.331 Tw T* (\024\027\022\024\035\024\020\017\017, \230\024\n\f\022\017\005 \027\026\006\ \017\024\027\026\035\034\027\t\005 \017\f\f\035\036\007\024\r\026\021\036\ \035\034)Tj 0 Tw (-)Tj 0.028 Tw T* [(\f\022\017\005 )0.5(\n\036\007\017\006\017\027\f\022\017\005 )0.6(\006\036\027\021\030 )0.5(\217\024\f\f\017\005\f\022\024\005 )0.5(\026\022\026\007\036\n\017\017 )0.5(\027\026\031\022; )]TJ 0 Tw 0 -1.218 TD (ORCID:)Tj /Span<>> BDC ( )Tj EMC (0000-0002-7599-1211)Tj 0.061 Tw 0 -1.218 TD (\223\036\030\027\016\022\024\r \202\035\036\022\f\026\027\007\030 \202\035\ \036\022\f\036\036\r\017\004)Tj /Span<>> BDC ( )Tj EMC (\227 \r\030\026\004-\024\030\007\017\027\026\021\024\030, )Tj 1.112 Tw 0 -1.218 TD (\203\026\031\004\027\024-\017\f\f\035\036\007\024\r\026\021\036\035\034\f\ \022\017\005 \017\027\f\021\017\021\031\021 \024\027\022\024\035\024\020\ \017\017, )Tj 0.853 Tw T* (\230\024\n\f\022\017\005 \027\026\006\017\024\027\026\035\034\027\t\005 \ \017\f\f\035\036\007\024\r\026\021\036\035\034\f\022\017\005 \n\036)Tj 0 Tw (-)Tj 0.836 Tw T* [(\007\017\006\017\027\f\022\017\005 \006\036\027\021\030 )0.5(\217\024\f\f\017\005\f\022\024\005 \026\022\026\007\036\n\017\017 \027\026\ \031\022; )]TJ 0 Tw T* (ORCID:)Tj /Span<>> BDC ( )Tj EMC (0000-0003-0829-0340.)Tj 0.391 Tw T* (\025\030\026\f\017\035\034\027\017\022\024\r \221\036\030\020\036\005 \224\ \007\031\026\030\007\024\r\017\004)Tj /Span<>> BDC ( )Tj EMC (\227 \007.\n.\027., \023\030\024)Tj 0 Tw (-)Tj 0.862 Tw T* [(\235\036\f\f\024\030, )0.5(\007\017\030\036\022\021\024\030, )0.6(\205\206\207\211 )0.5(\253\203\204\222\037 )0.6(\017\n\036\027\017 )0.6(\026\022\026)]TJ 0 Tw (-)Tj 0.898 Tw T* [(\007\036\n\017\022\026 \213.\203. \204\036\001\026\035\022\017\027\026\273\ )0.5(\204\017\027\007\030\026\r\026 \217\024\f\f\017\017; )]TJ 0 Tw T* (ORCID:)Tj /Span<>> BDC ( )Tj EMC (0000-0003-0687-0894)Tj 0.135 Tw T* (\234\031\n\036\005\022\017\027\026 \202\027\026\f\021\026\f\017\016 \210\ \035\036\020\024\r\027\026)Tj /Span<>> BDC ( )Tj EMC (\227 \r\030\026\004-\024\030\007\017\027\026\021\024\030, )Tj 0.406 Tw T* [(\205\206\207\211 )0.6(\253\203\204\222\037 )0.6(\017\n\036\027\017 )0.6(\026\022\026\007\036\n\017\022\026 )0.5(\213.\203. )0.5(\204\036\001\026\035\022\017\027\026\273 )]TJ 0 Tw T* (\204\017\027\007\030\026\r\026 \217\024\f\f\017\017)Tj 0.311 Tw T* (\230\030\031\013\031\022 \236\035\017\016 \204\017\b\026\005\035\024\r\027\ \026)Tj /Span<>> BDC ( )Tj EMC (\227 \r\030\026\004 \024\021\007\036\035\036\027\017\016 \024\027)Tj 0 Tw (-)Tj 0.554 Tw T* (\022\024\035\024\020\017\017 \2254, \203\026\031\004\027\024-\017\f\f\035\ \036\007\024\r\026\021\036\035\034\f\022\017\005 \017\027\f\021\017\021\031\ \021 )Tj 0.331 Tw 23.244 31.663 Td (\024\027\022\024\035\024\020\017\017, \230\024\n\f\022\017\005 \027\026\006\ \017\024\027\026\035\034\027\t\005 \017\f\f\035\036\007\024\r\026\021\036\ \035\034)Tj 0 Tw (-)Tj 0.028 Tw T* [(\f\022\017\005 )0.5(\n\036\007\017\006\017\027\f\022\017\005 )0.6(\006\036\027\021\030 )0.5(\217\024\f\f\017\005\f\022\024\005 )0.5(\026\022\026\007\036\n\017\017 )0.5(\027\026\031\022; )]TJ 0 Tw T* (ORCID: 0000-0001-5926-2601)Tj 0.462 Tw T* (\212\017\035\034 \210\035\034\020\026 \221\036\030\020\036\036\r\027\026\ )Tj /Span<>> BDC ( )Tj EMC (\227 \r\030\026\004-\024\027\022\024\035\024\020, \203\026\031\004\027\024\ -)Tj 0.626 Tw T* [(\017\f\f\035\036\007\024\r\026\021\036\035\034\f\022\017\005 )0.6(\017\027\f\021\017\021\031\021 )0.6(\024\027\022\024\035\024\020\017\017, )0.6(\230\024\n\f\022\017\005 )]TJ 1.854 Tw T* (\027\026\006\017\024\027\026\035\034\027\t\005 \017\f\f\035\036\007\024\r\ \026\021\036\035\034\f\022\017\005 \n\036\007\017\006\017\027)Tj 0 Tw (-)Tj 0.577 Tw 0 -1.218 TD (\f\022\017\005 \006\036\027\021\030 \217\024\f\f\017\005\f\022\024\005 \026\ \022\026\007\036\n\017\017 \027\026\031\022; ORCID: )Tj 0 Tw 0 -1.218 TD (0000-0001-6562-7574)Tj 0.584 Tw T* [(\223\036\030\027\t\001\024\r\026 \202\030\017\027\026 \213\r\020\036\027\ \034\036\r\027\026, )0.5(\f\021\031\007\036\027\021\022\026 \221\026\027\022\021-)]TJ 0.135 Tw T* (\215\036\021\036\030\002\031\030\020\f\022\024\020\024 \020\024\f\031\007\ \026\030\f\021\r\036\027\027\024\020\024 \031\027\017\r\036\030\f\017\021\ \036\021\026, \n\036)Tj 0 Tw (-)Tj T* (\007\017\006\017\027\f\022\017\005 \235\026\022\031\035\034\021\036\021)Tj 0.072 Tw T* (\202\030\b\017\023\024\r\026 \247\027\026 \222\020\024\030\036\r\027\026\ )Tj /Span<>> BDC ( )Tj EMC (\227 \r\030\026\004-\024\030\007\017\027\026\021\024\030, \203\026\031\004\ \027\024-)Tj 0.079 Tw 0 -1.218 TD (\017\f\f\035\036\007\024\r\026\021\036\035\034\f\022\017\005 \017\027\f\021\ \017\021\031\021 \024\027\022\024\035\024\020\017\017, \230\024\n\f\022\017\ \005 \027\026)Tj 0 Tw (-)Tj 0.167 Tw 0 -1.218 TD [(\006\017\024\027\026\035\034\027\t\005 )0.6(\017\f\f\035\036\007\024\r\026\021\036\035\034\f\022\017\005 )0.5(\n\036\007\017\006\017\027\f\022\017\005 )0.5(\006\036\027\021\030 )]TJ 0 Tw 0 -1.218 TD (\217\024\f\f\017\005\f\022\024\005 \026\022\026\007\036\n\017\017 \027\026\ \031\022)Tj /T1_0 1 Tf 0.023 Tw 0 -2.436 TD (INFORMATION ABOUT THE AUTHORS \(ORCID\):)Tj /T1_1 1 Tf 0 Tw 0 -1.218 TD [(Al)35(yona L. Cher)-14.9(ny)-13(shov)-15(a)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0002-8194-2811)Tj T* [(V)-15(i)-24(t)15(al)-31(iy A. Mar)-23.8(kov)-16(ich)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0002-7599-1211)Tj T* [(Ale)-18(x)-10.9(ander A. Cher)-14.9(ny)22(akov)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0003-0829-0340)Tj T* [(Ser)-32(ge)-11(y E. Kr)-32.9(asilnikov)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0003-0687-0894)Tj T* [(Anast)15(asia O. S)-15.9(humeik)-16(ina)]TJ T* [(Y)35(ul)-31(ia M. T)50.1(r)-22(ushchuk)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0001-5926-2601)Tj T* [(Ol)16(ga S. Dil)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0001-6562-7574)Tj T* [(Ar)-37(ina E. Cher)-14.9(ny)-13(shov)-14.9(a)]TJ T* [(Y)50(ana I. Ar)-23.9(khipov)-15(a)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 70.936 371.6679 Tm [(\r\031\024\034\033)48(\026)45(\024)-10(\223\033)48(\026/REFERENCES)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0 Tc 0.051 Tw 8 0 0 8 70.8661 358.8332 Tm (1.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Baile)-11(y)]TJ /Span<>> BDC ( )Tj EMC (CE, Hu)Tj /Span<>> BDC ( )Tj EMC [(CY, Y)40(ou)]TJ /Span<>> BDC ( )Tj EMC [(YN, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Incr)-23.9(easing disp)32(ar)-37(i)-23.9(t)-32(ies in t)-13(he a)-17(ge-)]TJ 0.081 Tw -1.296 -1.25 Td [(r)-24(el)-16(a)15.1(ted inc)-23.9(idences of col)30(on and r)-23.9(ec)-16(t)15(al cancer)-10(s in t)-13(he U)13(ni)-24(ted S)15(t)15(a)15(tes, )]TJ 0 Tw 0 -1.25 TD (1975-2010. )Tj /T1_3 1 Tf 0.029 Tw 4.91 0 Td [(J)30(AMA Surg.)]TJ /T1_1 1 Tf [( 2015 Jan;150\(1\):17\22622. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1001/jama)Tj (-)Tj -4.91 -1.25 Td [(sur)-32(g.2014.1756)]TJ 0 0 0 1 k /GS1 gs 0.277 Tw [( )0.6(Er)-24(r)-32.9(a)15(tum )0.5(in: )0.6(J)15(AMA )0.6(Sur)-32(g. )0.6(2015 )0.5(Mar )0.6(1;150\(3\):277. )]TJ 0.023 Tw T* (PMID: 25372703; PMCID: PMC4666003.)Tj 0.198 Tw T* (2.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(P)30(ell)-31(ino)]TJ /Span<>> BDC ( )Tj EMC [(G, S)-16(imill)-30.9(is)]TJ /Span<>> BDC ( )Tj EMC [(C, K)25(ont)17(ovounisios)]TJ /Span<>> BDC ( )Tj EMC [(C, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Col)30(or)-23.9(ec)-16(t)15(al cancer )]TJ 0.007 Tc 0.35 Tw -1.296 -1.25 Td [(dia)-17.1(gnosed dur)-37.1(ing p)24.8(r)-24.1(egnancy: sy)-13.1(stema)14.9(t)-32.1(ic r)-24.1(ev)-16.1(iew and tr)-24.1(ea)14.9(tment)7.1( )]TJ 0 Tc 0 Tw T* [(p)32(a)15(t)-13(hw)-12(a)15.1(y)-13(s. )]TJ /T1_3 1 Tf 0.326 Tw 4.593 0 Td [(Eur )0.5(J )0.5(Gastroenterol )0.6(Hepatol)]TJ /T1_1 1 Tf [(. )0.5(2017 )0.5(Jul;29\(7\):743\226753. )]TJ 0 Tw -4.593 -1.25 Td [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1097/MEG.0000000000000863)Tj 0 0 0 1 k /GS1 gs 0.023 Tw ( PMID: 28252463.)Tj 0.002 Tw -1.847 -1.25 Td (3.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Y)50(a)-17(gho)-16(obi)]TJ /Span<>> BDC ( )Tj EMC [(M, K)25(or)-24(en)]TJ /Span<>> BDC ( )Tj EMC (G, Nulman)Tj /Span<>> BDC ( )Tj EMC [(I. Challenges t)17(o dia)-17(gnosing col)30(or)-23.9(ec)]TJ 0 Tw (-)Tj -0.055 Tw -1.296 -1.25 Td [(t)15(al )0.5(cancer )0.5(dur)-36.9(ing )0.5(p)25(r)-24(egnancy. )]TJ /T1_3 1 Tf 11.537 0 Td [(Can )0.5(F)15(am )0.5(Ph)12(ysician.)]TJ /T1_1 1 Tf [( )0.5(2009 )0.5(Sep;55\(9\):881\226)]TJ 0.023 Tw -11.537 -1.25 Td (5. PMID: 19752253; PMCID: PMC2743581.)Tj 0.344 Tw T* (4.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Q)-16(ur)-24(eshi)]TJ /Span<>> BDC ( )Tj EMC [(W)31(A, R)-10(ajan)]TJ /Span<>> BDC ( )Tj EMC [(E, A)15(dler)]TJ /Span<>> BDC ( )Tj EMC [(DG, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Amer)-36.9(ican S)-16(o)-16(c)-24(ie)-12(t)-10(y for )]TJ 0.147 Tw -1.296 -1.25 Td [(Gastr)-32(ointest)-31.9(inal End)-16(oscopy. A)35(SGE Guidel)-30.9(ine: Guidel)-31(ines for end)-16(os)]TJ 0 Tw (-)Tj 0.178 Tw T* [(copy in p)25(r)-24(egnant and l)-16(a)-17(c)-16(t)15(a)15(t)-32(ing w)-14(omen. )]TJ /T1_3 1 Tf (Gastrointest Endosc)Tj /T1_1 1 Tf (. 2005 )Tj 0.01 Tc 0.382 Tw T* [(Mar;61\(3\):357\22662. d)-16.2(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs -0.01 Tw (10.1016/s0016-5107\(04\)02780-4)Tj 0 0 0 1 k /GS1 gs 0.382 Tw [( PMID:)10( )]TJ 0 Tc 0 Tw T* (15758903.)Tj 0.258 Tw T* (5.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(M)-24(or)-33(an)]TJ /Span<>> BDC ( )Tj EMC [(BJ, Y)50(ano)]TJ /Span<>> BDC ( )Tj EMC [(H, Al Z)10(ahir)]TJ /Span<>> BDC ( )Tj EMC [(N, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Confl)-30.9(ic)-16(t)-32(ing p)25(r)-37(ior)-37(i)-23.9(t)-32(ies in )]TJ 0.18 Tw -1.296 -1.25 Td [(sur)-32(gical inter)-31.9(vent)-32(ion for cancer in p)25(r)-23.9(egnancy. )]TJ /T1_3 1 Tf (Lancet Oncol)Tj /T1_1 1 Tf (. 2007 )Tj 0.013 Tc 0.467 Tw T* [(Jun;8\(6\):536\22644. d)-15.6(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs -0.013 Tw (10.1016/S1470-2045\(07\)70171-7)Tj 0 0 0 1 k /GS1 gs 0.467 Tw [( PMID:)13( )]TJ 0 Tc 0 Tw T* (17540305.)Tj 0.289 Tw T* (6.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Cohen-K)25(er)-23.9(em)]TJ /Span<>> BDC ( )Tj EMC [(R, R)-10(ail)56(t)17.1(on)]TJ /Span<>> BDC ( )Tj EMC [(C, Or)-24(en)]TJ /Span<>> BDC ( )Tj EMC [(D, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. P)35(r)-24(egnancy outcome )]TJ 0.347 Tw -1.296 -1.25 Td [(foll)30(o)-14(wing )0.6(non-obste)-11.9(tr)-37(ic )0.6(sur)-32(gical )0.6(inter)-32(vent)-32(ion. )]TJ /T1_3 1 Tf 20.157 0 Td [(Am )0.6(J )0.5(Surg.)]TJ /T1_1 1 Tf [( )0.5(2005 )]TJ 0.011 Tc 0.415 Tw -20.157 -1.25 Td [(Sep;190\(3\):467\22673. d)-16.2(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs -0.011 Tw [(10.1016/j.amjsur)-32.2(g.2005.03.033)]TJ 0 0 0 1 k /GS1 gs 0.415 Tw [( PMID:)11( )]TJ 0 Tc 0 Tw 0 -1.25 Td (16105538.)Tj 0.177 Tw T* (7.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(W)12(alsh)]TJ /Span<>> BDC ( )Tj EMC [(C, F)20(a)-24(zio)]TJ /Span<>> BDC ( )Tj EMC [(VW. Cancer of t)-13(he col)30(on, r)-24(ec)-16(tum, and anus dur)]TJ 0 Tw 25.99 0 Td (-)Tj 0.16 Tw -27.286 -1.25 Td [(ing )0.6(p)25(r)-24(egnancy. )0.6(T)47(he )0.5(sur)-32(geon\245s )0.6(per)-10(spec)-16(t)-31.9(i)-16(ve. )]TJ /T1_3 1 Tf 17.927 0 Td [(Gastroenterol )0.7(Clin )0.5(N)17(or)-39.9(th )]TJ 0 Tw -17.927 -1.25 Td (Am)Tj /T1_1 1 Tf 0.086 Tw [(. 1998 Mar;27\(1\):257\22667. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1016/s0889-8553\(05\)70356-3)Tj 0 0 0 1 k /GS1 gs ( )Tj 0.023 Tw 29.055 33.75 Td (PMID: 9546093.)Tj 0.289 Tw T* (8.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Cohen-K)25(er)-23.9(em)]TJ /Span<>> BDC ( )Tj EMC [(R, R)-10(ail)56(t)17.1(on)]TJ /Span<>> BDC ( )Tj EMC [(C, Or)-24(en)]TJ /Span<>> BDC ( )Tj EMC [(D, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. P)35(r)-24(egnancy outcome )]TJ 0.347 Tw -1.296 -1.25 Td [(foll)30(o)-14(wing )0.6(non-obste)-11.9(tr)-37(ic )0.6(sur)-32(gical )0.6(inter)-32(vent)-32(ion. )]TJ /T1_3 1 Tf 20.157 0 Td [(Am )0.6(J )0.5(Surg.)]TJ /T1_1 1 Tf [( )0.5(2005 )]TJ 0.011 Tc 0.415 Tw -20.157 -1.25 Td [(Sep;190\(3\):467\22673. d)-16.2(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs -0.011 Tw [(10.1016/j.amjsur)-32.2(g.2005.03.033)]TJ 0 0 0 1 k /GS1 gs 0.415 Tw [( PMID:)11( )]TJ 0 Tc 0 Tw T* (16105538.)Tj 0.205 Tw T* (9.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(P)30(er)-24(eg)]TJ /Span<>> BDC ( )Tj EMC [(D, K)25(or)-23.9(en)]TJ /Span<>> BDC ( )Tj EMC [(G, L)-32(ishner)]TJ /Span<>> BDC ( )Tj EMC [(M. Cancer in p)25(r)-23.9(egnancy: gaps, chal)]TJ 0 Tw (-)Tj 0.299 Tw -1.296 -1.25 Td [(lenges and sol)35(ut)-32(ions. )]TJ /T1_3 1 Tf [(Cancer T)56.1(reat R)21(ev)]TJ /T1_1 1 Tf (. 2008 Jun;34\(4\):302\22612. )Tj 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td [(10.1016/j.c)-15.9(tr)-32(v.2008.01.002)]TJ 0 0 0 1 k /GS1 gs 0.023 Tw ( Epub 2008 Mar 4. PMID: 18291591.)Tj 0.009 Tc 0.35 Tw -1.847 -1.25 Td (10.)Tj /Span<>> BDC ( )Tj EMC 1.833 0 Td (Cao)Tj /Span<>> BDC ( )Tj EMC [(S, Ok)9.7(ekpe)]TJ /Span<>> BDC ( )Tj EMC [(CC, Dombr)-32.3(ovsk)-32.3(y)]TJ /Span<>> BDC ( )Tj EMC [(I, e)-12.3(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Col)29.7(or)-24.3(ec)-16.3(t)14.7(al Cancer)9( )]TJ 0 Tc 0.091 Tw -1.833 -1.25 Td [(Dia)-17(gnosed Dur)-37(ing P)35(r)-23.9(egnancy W)-16(i)-24(t)-12.9(h Del)-16(a)15(yed T)50(r)-24(ea)15(tment. )]TJ /T1_3 1 Tf 0 Tw (Cureus)Tj /T1_1 1 Tf 0.091 Tw (. 2020 )Tj 0.259 Tw T* [(Ma)15(y 24;12\(5\):e8261. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw [(10.7759/cur)-23.9(eus.8261)]TJ 0 0 0 1 k /GS1 gs 0.259 Tw ( PMID: 32596079; )Tj 0.023 Tw T* (PMCID: PMC7313435.)Tj 0.031 Tw T* (11.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Dover)-10(spik)10.1(e)]TJ /Span<>> BDC ( )Tj EMC [(L, K)25(ur)-22(tz)]TJ /Span<>> BDC ( )Tj EMC [(S, Sel)30.1(v)-15(a)-17(ggi)]TJ /Span<>> BDC ( )Tj EMC [(K. P)40(all)-30.9(ia)15(t)-32(i)-16(ve Chemo)17(t)-12.9(her)-33(apy: Does )]TJ 0.135 Tw -1.796 -1.25 Td [(It Onl)35(y P)35(r)-32(ov)-15.9(ide F)20(alse Hope? T)47(he R)11(ole of P)40(all)-31(ia)15(t)-32(i)-16(ve Car)-24(e in a Y)40(oung )]TJ 0.218 Tw T* [(P)40(a)15(t)-32(ient )0.6(W)-16(i)-24(t)-12.9(h )0.5(Newl)35(y )0.6(Dia)-17(gnosed )0.6(Me)-12(t)15(ast)15(a)15(t)-32(ic )0.6(A)15(deno)-16(car)-31.9(c)-24(inoma. )]TJ /T1_3 1 Tf 25.321 0 Td [(J )0.6(Adv )]TJ 0.076 Tw -25.321 -1.25 Td (Pract Oncol)Tj /T1_1 1 Tf [(. 2017 Ma)15(y-Jun; 8\(4\):382\226386. Epub 2017 Ma)15(y 1. PMID: )]TJ 0.023 Tw T* (30018843; PMCID: PMC6040871.)Tj 0.085 Tw T* (12.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(V)25(an Calster)-23.9(en)]TJ /Span<>> BDC ( )Tj EMC [(K. Chemo)17.1(t)-13(her)-33(apy dur)-36.9(ing p)25(r)-24(egnancy: phar)-16(ma)-17(cok)-16(i)]TJ 0 Tw (-)Tj -0.036 Tw -1.796 -1.25 Td [(ne)-12(t)-32(ics )0.5(and im)10(p)32(a)-17(c)-16(t )0.5(on foe)-12(t)15(al )0.5(neur)-32(ol)30(o)-16(gical devel)30(opment. )]TJ /T1_3 1 Tf 21.96 0 Td [(F)15(acts )0.5(Vie)10(ws Vis )]TJ 0 Tw -21.96 -1.25 Td (Obgyn)Tj /T1_1 1 Tf 0.023 Tw (. 2010;2\(4\):278\22686. PMID: 25009715; PMCID: PMC4086012.)Tj 0.137 Tw T* (13.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Car)-24(d)-16(onick)]TJ /Span<>> BDC ( )Tj EMC [(E, Ia)-17(cobucc)-23.9(i)]TJ /Span<>> BDC ( )Tj EMC [(A. Use of chemo)17.1(t)-13(her)-33(apy dur)-36.9(ing human )]TJ 0.001 Tc -0.001 Tw -1.796 -1.25 Td [(p)25.1(r)-23.8(egnancy. )]TJ /T1_3 1 Tf 0.349 Tw 5.054 0 Td (Lancet Oncol)Tj /T1_1 1 Tf [(. 2004 Ma)15.1(y;5\(5\):283\22691. d)-15.9(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs -0.001 Tw (10.1016/)Tj 0 Tc 0 Tw -5.054 -1.25 Td (S1470-2045\(04\)01466-4)Tj 0 0 0 1 k /GS1 gs 0.023 Tw ( PMID: 15120665.)Tj 0.12 Tw T* (14.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(R)11(o)-16(ger)-10(s)]TJ /Span<>> BDC ( )Tj EMC [(JE, Dasar)-36.9(i)]TJ /Span<>> BDC ( )Tj EMC (A, Eng)Tj /Span<>> BDC ( )Tj EMC [(C. T)47(he T)50(r)-24(ea)15.1(tment of Col)30(or)-24(ec)-16(t)15(al Cancer )]TJ 0.232 Tw -1.796 -1.25 Td [(Dur)-37(ing P)35.1(r)-24(egnancy: Cy)-16(t)17(o)17(t)17.1(o)13.9(xic Chemo)17(t)-13(her)-32.9(apy and T)40(ar)-32(ge)-12(ted T)47(her)-32.9(apy )]TJ 0 Tw T* (Challenges. )Tj /T1_3 1 Tf 4.977 0 Td (Oncologist)Tj /T1_1 1 Tf 0.139 Tw [(. 2016 Ma)15(y;21\(5\):563\22670. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw [(10.1634/t)-12.9(he)]TJ (-)Tj -4.977 -1.25 Td [(oncol)30(o)-16(gist.2015-0362)]TJ 0 0 0 1 k /GS1 gs 0.115 Tw ( Epub 2016 Mar 21. PMID: 27000464; PMCID: )Tj 0 Tw T* (PMC4861360.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\033\030\031\030\213\b)-20.9(\035\231\213\233\t \021\032)50(\b)42(\032\231\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj -51.938 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 23, \023\0221)69(, 202)69(4)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 23, \023\0221)69(, 202)69(4)]TJ /T1_5 1 Tf 25 0 0 25 20.7776 56.0378 Tm (106)Tj ET endstream endobj 1435 0 obj <>/Border[0 0 0]/H/N/Rect[243.833 346.129 291.968 336.673]/Subtype/Link/Type/Annot>> endobj 1436 0 obj <>/Border[0 0 0]/H/N/Rect[70.8661 336.129 121.634 326.833]/Subtype/Link/Type/Annot>> endobj 1437 0 obj <>/Border[0 0 0]/H/N/Rect[85.6442 286.129 195.42 276.833]/Subtype/Link/Type/Annot>> endobj 1438 0 obj <>/Border[0 0 0]/H/N/Rect[156.461 216.129 267.411 206.833]/Subtype/Link/Type/Annot>> endobj 1439 0 obj <>/Border[0 0 0]/H/N/Rect[154.521 176.129 266.629 166.833]/Subtype/Link/Type/Annot>> endobj 1440 0 obj <>/Border[0 0 0]/H/N/Rect[161.158 136.129 267.105 126.833]/Subtype/Link/Type/Annot>> endobj 1441 0 obj <>/Border[0 0 0]/H/N/Rect[183.393 96.1293 291.968 86.6732]/Subtype/Link/Type/Annot>> endobj 1442 0 obj <>/Border[0 0 0]/H/N/Rect[393.599 336.129 499.546 326.833]/Subtype/Link/Type/Annot>> endobj 1443 0 obj <>/Border[0 0 0]/H/N/Rect[318.085 296.129 408.468 286.833]/Subtype/Link/Type/Annot>> endobj 1444 0 obj <>/Border[0 0 0]/H/N/Rect[393.198 266.129 462.821 256.833]/Subtype/Link/Type/Annot>> endobj 1445 0 obj <>/Border[0 0 0]/H/N/Rect[494.449 156.129 524.409 146.673]/Subtype/Link/Type/Annot>> endobj 1446 0 obj <>/Border[0 0 0]/H/N/Rect[303.307 146.129 382.563 136.833]/Subtype/Link/Type/Annot>> endobj 1447 0 obj <>/Border[0 0 0]/H/N/Rect[480.874 116.129 524.409 106.673]/Subtype/Link/Type/Annot>> endobj 1448 0 obj <>/Border[0 0 0]/H/N/Rect[303.307 106.129 374.258 96.8332]/Subtype/Link/Type/Annot>> endobj 1462 0 obj <> endobj 1461 0 obj <> endobj 1460 0 obj <> endobj 1459 0 obj <> endobj 1458 0 obj <> endobj 1457 0 obj <> endobj 1456 0 obj <> endobj 1455 0 obj <> endobj 1454 0 obj <> endobj 1453 0 obj <> endobj 1452 0 obj <> endobj 1451 0 obj <> endobj 1450 0 obj <> endobj 1449 0 obj <> endobj 1164 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1165 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1166 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1167 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1168 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1467 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\037)31(\025\007\025\002\016\n)-10(\026)11(\013\007\216\001\020\203 \002\013\n \220\022\f\016\002\016\024\016\001\001\ \025\006)-10(\026\216)]TJ 47.216 0 Td [(Color)31(ectal cancer and pr)31(egnancy)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0.236 Tw 10 0 0 10 42.5197 724.8299 Tm (\020\036\f\021\026\006\017\024\027\027\t\005 \f\030\024\022 29\22630)Tj /Span<>> BDC ( )Tj EMC (\027\036\007\036\035\034. \025\030\024\n\036 \021\024\020\024, \024\002)Tj 0 Tw (-)Tj 0.207 Tw 0 -1.218 TD (\030\026\013\026\035\017 \027\026)Tj /Span<>> BDC ( )Tj EMC (\f\036\002\016 \r\027\017\n\026\027\017\036 \f\035\036\007\031\033\013\017\ \036 \024\f\024\002\036\027\027\024\f\021\017 )Tj 0.486 Tw T* (\026\027\026\n\027\036\026 \023\026\006\017\036\027\021\022\017: \007\026\ \027\027\026\016 \002\036\030\036\n\036\027\027\024\f\021\034 \002\t\035\ \026 )Tj 0.173 Tw T* (\f\036\007\034\n\026\016, \r)Tj /Span<>> BDC ( )Tj EMC (\026\027\026\n\027\036\036 \004\036\021\r\036\030\024 \030\024\007\024\r\ , \024\007\017\027 \r\t\022\017\007\t\001 )Tj 0.368 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC [(\024\007\027\024 \n\036\007\017\022\026\n\036\027\021\024\027\024\036 )0.5(\023\030\036\030\t\r\026\027\017\036 \002\036\030\036\n\036\027\027\024)]TJ 0 Tw (-)Tj 0.272 Tw T* (\f\021\017. \206\017\027\036\022\024\035\024\020\017\004\036\f\022\017\036\ \026\002\024\035\036\r\026\027\017\016: \n\017\024\n\026 \n\026\021\022\ \017. )Tj 0.026 Tw 0 -1.218 TD (\230\026\022\032\036 \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\022\017 \017\n\036\035\026\f\034 \r\t\030\026\ \032\036\027\027\026\016 \f\024\023\031\021\f\021\r\031\033)Tj 0 Tw (-)Tj 0.12 Tw 0 -1.218 TD (\013\026\016 \023\026\021\024\035\024\020\017\016: \n\036\021\026\002\024\ \035\017\004\036\f\022\017\005 \f\017\027\007\030\024\n, \024\032\017\030\ \036\027\017\036 )Tj 0.039 Tw T* (3)Tj /Span<>> BDC ( )Tj EMC (\f\021\036\023\036\027\017 \(\222\204\230 44\), \020\017\023\036\030\021\ \024\027\017\004\036\f\022\026\016 \002\024\035\036\027\034, \020\036\f\ \021\026)Tj 0 Tw (-)Tj 0.029 Tw T* [(\006\017\024\027\027\t\005 )0.6(\f\026\b\026\030\027\t\005 )0.5(\007\017\026\002\036\021, )0.5(\002\030\024\027\b\017\026\035\034\027\026\016 )0.7(\026\f\021\n\026 )0.5(\(\035\036\020)]TJ 0 Tw (-)Tj 0.213 Tw T* (\022\024\036 \021\036\004\036\027\017\036\), \b\030\024\027\017\004\036\f\ \022\017\005 \023\017\036\035\024\027\036\235\030\017\021)Tj /Span<>> BDC ( )Tj EMC (\227 \f\021\026\007\017\016 )Tj 0.117 Tw T* (\030\036\n\017\f\f\017\017. \200)Tj /Span<>> BDC ( )Tj EMC (\026\027\026\n\027\036\036 \f\017\235\017\035\017\f, \023\030\024\035\036\ \004\036\027 \r)Tj /Span<>> BDC ( )Tj EMC (2006)Tj /Span<>> BDC ( )Tj EMC (\020., )Tj 0.285 Tw 0 -1.218 TD (\023\030\024\235\017\035\026\022\021\017\004\036\f\022\024\036 \035\036\004\ \036\027\017\036 \r)Tj /Span<>> BDC ( )Tj EMC (\027\026\f\021\024\016\013\031\033 \002\036\030\036\n\036\027)Tj 0 Tw (-)Tj 0 -1.218 TD (\027\024\f\021\034 \027\036 \023\030\024\r\024\007\017\035\024\f\034.)Tj 0.415 Tw 0 -1.218 TD (\215\026\006\017\036\027\021\022\026 \002\t\035\026 \027\026\023\030\026\ \r\035\036\027\026 \007\035\016 \007\024\024\002\f\035\036\007\024\r\026\ \027\017\016 )Tj 0.099 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\035\036\004\036\027\017\016 \r)Tj /Span<>> BDC ( )Tj EMC (\020.)Tj /Span<>> BDC ( )Tj EMC (\230\024\n\f\022. \200)Tj /Span<>> BDC ( )Tj EMC (\230\024\n\f\022\024\n \024\002\035\026\f\021\027\024\n \024\027\022\024\ \035\024)Tj 0 Tw (-)Tj 0.102 Tw T* (\020\017\004\036\f\022\024\n \007\017\f\023\026\027\f\036\030\036 \002\t\ \035\024 \023\030\024\r\036\007\036\027\024 \007\024\024\002\f\035\036\007\ \024\r\026)Tj 0 Tw (-)Tj 0.167 Tw T* (\027\017\036: \023\024)Tj /Span<>> BDC ( )Tj EMC (\026\027\026\035\017\026\n \r\t\016\r\035\036\027\026 \026\027\036\n\017\ \016 \035\036\020\022\024\005 \f\021\036\023\036\027\017 )Tj 0.03 Tw T* (\021\016\032\036\f\021\017. \215\030\017)Tj /Span<>> BDC ( )Tj EMC (\030\036\022\021\026\035\034\027\024\n \024\f\n\024\021\030\036: \023\036\ \030\017\026\027\026\035\034\027\026\016 \024\002)Tj 0 Tw (-)Tj 0.01 Tw T* (\035\026\f\021\034 \027\036 \017\n\036\027\036\027\026, \021\024\027\031\ \f \f\235\017\027\022\021\036\030\026 \f\024\b\030\026\027\036\027, \027\ \026)Tj /Span<>> BDC ( )Tj EMC (\r\t)Tj 0 Tw (-)Tj 0.217 Tw T* (\f\024\021\036 7 \f\n \024\021 \026\027\031\f\026 \023\026\035\034\023\017\ \030\031\036\021\f\016 \022\030\026\021\036\030\024\024\002\030\026\027\ \t\005 )Tj 0.098 Tw T* (\007\036\235\036\022\021 \007\024)Tj /Span<>> BDC ( )Tj EMC (1,5)Tj /Span<>> BDC ( )Tj EMC (\f\n \r)Tj /Span<>> BDC ( )Tj EMC (\007\017\026\n\036\021\030\036, \022\024\027\021\026\022\021\027\024 \022\ \030\024\r\024\021\024\004\017\021. )Tj 0.016 Tw T* (\215\030\017)Tj /Span<>> BDC ( )Tj EMC [(\023\030\024\r\036\007\036\027\017\017 \030\036\022\021\024\030\024\n\026\ \027\024\f\022\024\023\017\017: )0.5(\f\035\017\017\f\021\026\016 )0.5(\023\030\016)]TJ 0 Tw (-)Tj -0.035 Tw T* (\n\024\005 \022\017\001\022\017 \030\024\024\r\026\016, \027\026)Tj /Span<>> BDC ( )Tj EMC (\030\026\f\f\021\024\016\027\017\017 7)Tj /Span<>> BDC ( )Tj EMC (\f\n \024\021 \026\027\031\f\026 \027\026)Tj /Span<>> BDC ( )Tj EMC (12 )Tj 0.138 Tw T* [(\004\026\f\026\b )0.6(\017\n\036\036\021\f\016 )0.6(\016\r\036\027\027\t\005 )0.7(\007\036\235\036\022\021 )0.6(\007\024)]TJ /Span<>> BDC ( )Tj EMC 15.368 0 Td [(5 )0.6(\n\n, )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC 3.375 0 Td (\027\026\035\036\021\024\n )Tj 0.198 Tw -18.743 -1.218 Td (\235\017\002\030\017\027\026. \215\030\024\r\036\007\036\027\026 \002\017\ \024\023\f\017\016. \206\017\f\021\024\035\024\020\017\004\036\f\022\024\ \036 \026)Tj 0 Tw (-)Tj 0.023 Tw T* (\022\035\033\004\036\027\017\036 \023\024)Tj /Span<>> BDC ( )Tj EMC (\030\036\031\035\034\021\026\021\026\n \002\017\024\023\f\017\017 \f\035\ \017\017\f\021\024\005 \023\030\016\n\024\005 )Tj 0.027 Tw T* (\022\017\001\022\017: \235\030\026\020\n\036\027\021 \f\035\017\017\f\021\ \024\005 \024\002\024\035\024\004\022\017 \021\024\035\f\021\024\005 \022\ \017\001\022\017 )Tj 0.132 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\220\030\024\017\030\024\r\026\027\017\036\n, \r\t\030\026\032\036\027\027\ \024\005 \f\n\036\001\026\027\027\024 \022\035\036\021\024\004\027\024\005\ )Tj 0.385 Tw T* (\017\027\235\017\035\034\021\030\026\006\017\036\005, \027\026\035\017\004\ \017\036\n \022\024\n\023\035\036\022\f\024\r \017\027\r\026\017\r\027\024\ )Tj 0 Tw (-)Tj 0.209 Tw T* [(\020\024 )0.5(\026\007\036\027\024\020\036\027\027\024\020\024 )0.5(\027\017\022\024\007\017\235\235\036\030\036\027\006\017\030\024\r\026\027\ \027\024\020\024 )0.6(\030\026\022\026. )]TJ 0.095 Tw T* (\215\024)Tj /Span<>> BDC ( )Tj EMC (\007\026\027\027\t\n \204\217\230 \024\030\020\026\027\024\r \n\026\035\024\ \020\024 \021\026\026 \r\t\016\r\035\036\027\t \023\030\017)Tj 0 Tw (-)Tj 0.157 Tw T* (\027\026\022\017 \031\021\024\035\013\036\027\017\016 \f\021\036\027\024\ \022 \f\030\036\007\027\036\026\n\023\031\035\016\030\027\024\020\024 \024\ \021\007\036\035\026 )Tj 0.067 Tw T* (\023\030\016\n\024\005 \022\017\001\022\017 \f)Tj /Span<>> BDC ( )Tj EMC (\027\036\002\024\035\034\001\017\n\017 \021\016\032\026\n\017 \r)Tj /Span<>> BDC ( )Tj EMC (\023\026\030\026\030\036\022\021\026\035\034)Tj 0 Tw (-)Tj -0.03 Tw T* (\027\031\033 \022\035\036\021\004\026\021\022\031 \f\035\036\r\026)Tj /Span<>> BDC ( )Tj EMC (\227 \002\024\035\036\036 \r\036\030\024\016\021\027\024, \r)Tj /Span<>> BDC ( )Tj EMC (\030\026\n\022\026\b \007\036\f)Tj 0 Tw (-)Tj 0.213 Tw T* (\n\024\023\035\026\f\021\017\004\036\f\022\024\005 \030\036\026\022\006\017\ \017, \n\036\027\036\036 \r\036\030\024\016\021\027\024, \f\036\021\004\026\ \021\026\016 )Tj 0.138 Tw T* (\017\027\r\026\017\016. \211\r\036\035\017\004\036\027\027\t\b \035\017\ \n\235\026\021\017\004\036\f\022\017\b \031\035\024\r \027\036 \r\t)Tj 0 Tw (-)Tj 0.235 Tw T* [(\016\r\035\036\027\024. )0.5(\210\007\027\024\023\035\024\007\027\026\016 )0.6(\002\036\030\036\n\036\027\027\024\f\021\034 )0.6(33 )0.5(\027\036\007\036\035\017, )0.6(\020\024)]TJ 0 Tw (-)Tj T* (\035\024\r\027\024\036 \023\030\036\007\035\036\032\026\027\017\036.)Tj 0.006 Tc 0.201 Tw T* (\211\004\017\021\t\r\026\016 \007\026\027\027\t\036 \026\027\026\n\027\036\ \026 \017)Tj /Span<>> BDC ( )Tj EMC (\030\036\031\035\034\021\026\021\t \024\002\f\035\036\007\024)Tj 0 Tc 0 Tw (-)Tj 0.006 Tc 0.083 Tw T* (\r\026\027\017\016, \002\t\035\024 \023\030\017\027\016\021\024 \030\036\ \001\036\027\017\036 \024)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\r\036\007\036\027\017\017 \022\024\027\f\017)Tj 0 Tc 0 Tw (-)Tj 0.006 Tc 0.062 Tw T* (\035\017\031\n\026 \027\026)Tj /Span<>> BDC ( )Tj EMC [(\002\026\036 \230\024\n\f\022\024\020\024 \024\002\035\026\f\021\027\024\ \020\024 \023\036\030\017\027\026\021\026\035\034\027\024\020\024)6( )]TJ -0.022 Tw T* (\006\036\027\021\030\026 \f)Tj /Span<>> BDC ( )Tj EMC [(\031\004\026\f\021\017\036\n \r\030\026\004\036\005-\024\027\022\024\035\ \024\020\024\r \203\222\222 \024\027\022\024\035\024\020\017\017)6( )]TJ 0.245 Tw T* [(\230\024\n\f\022\024\020\024 )0.5(\203\222\204\037 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 8.358 0 Td [(\230\024\n\f\022\024\020\024 )0.5(\024\002\035\026\f\021\027\024\020\024 )0.5(\024\027\022\024\035\024\020\017)]TJ 0 Tc 0 Tw (-)Tj 0.006 Tc 0.166 Tw -8.358 -1.218 Td (\004\036\f\022\024\020\024 \007\017\f\023\026\027\f\036\030\026. \003\026\ \022\035\033\004\036\027\017\036 \022\024\027\f\017\035\017\031\n\026: \031\ \004\017)Tj 0 Tc 0 Tw (-)Tj 0.006 Tc 0.289 Tw T* (\021\t\r\026\016 \f\030\024\022 \002\036\030\036\n\036\027\027\024\f\021\ \017 33\22634)Tj /Span<>> BDC ( )Tj EMC [(\027\036\007\036\035\017, \027\026\035\017\004\017\036)6( )]TJ 0.275 Tw T* [(\024\027\022\024\035\024\020\017\004\036\f\022\024\020\024 \026\002\024\ \035\036\r\026\027\017\016 \(\217\026\022 \023\030\016\n\024\005 \022\017\ \001\022\017)6( )]TJ 0.334 Tw T* (T2NxM0, GIII\), \031\007\024\r\035\036\021\r\024\030\017\021\036\035\034\ \027\024\036 \f\024\f\021\024\016\027\017\036 \023\026)Tj 0 Tc 0 Tw (-)Tj 0.006 Tc 0.207 Tw T* (\006\017\036\027\021\022\017 \017)Tj /Span<>> BDC ( )Tj EMC (\023\035\024\007\026, \027\026)Tj /Span<>> BDC ( )Tj EMC [(\007\026\027\027\024\n \220\021\026\023\036 \030\036\022\024\n\036\027\007\ \024\r\026\027\024)6( )]TJ 0.087 Tw T* (\023\030\024\035\024\027\020\017\030\024\r\026\021\034 \002\036\030\036\n\ \036\027\027\024\f\021\034 \007\024)Tj /Span<>> BDC ( )Tj EMC (37 \027\036\007\036\035\034 \f)Tj /Span<>> BDC ( )Tj EMC (\007\026\035\034)Tj 0 Tc 0 Tw (-)Tj 0.006 Tc 0.473 Tw T* (\027\036\005\001\036\n \030\024\007\024\030\026\030\036\001\036\027\017\ \036\n \023\024)Tj /Span<>> BDC ( )Tj EMC (\026\022\031\001\036\030\f\022\017\n \023\024\022\026)Tj 0 Tc 0 Tw (-)Tj 0.006 Tc 0.289 Tw T* (\026\027\017\016\n. \215\024\f\035\036 \030\024\007\024\030\026\030\036\ \001\036\027\017\016 \023\035\026\027\017\030\031\036\021\f\016 \023\030\ \024)Tj 0 Tc 0 Tw (-)Tj 0.006 Tc 0.308 Tw T* (\r\036\007\036\027\017\036 \f\023\036\006\017\026\035\034\027\024\020\024\ \035\036\004\036\027\017\016 \r)Tj /Span<>> BDC ( )Tj EMC [(\024\027\022\024\035\024\020\017\004\036\f\022\024\n)6( )]TJ -0.006 Tw T* (\031\004\030\036\032\007\036\027\017\017.)Tj 0.004 Tc 0.266 Tw 23.244 64.543 Td [(\200 )0.5(\f\030\024\022 )0.5(37 )0.6(\027\036\007\036\035\034 )0.5(\023\026\006\017\036\027\021\022\036 )0.5(\002\t\035\024 )0.5(\023\030\024\r\036\007\036\027\024 )0.5(\030\024)]TJ 0 Tc 0 Tw (-)Tj 0.004 Tc 0.317 Tw T* [(\007\024\030\026\030\036\001\036\027\017\036 \023\031\021\036\n \024\023\ \036\030\026\006\017\017 \022\036\f\026\030\036\r\024 \f\036\004\036\027\ \017\036.)4( )]TJ 0.032 Tw T* (\217\024\007\017\035\f\016 \n\026\035\034\004\017\022 \r\036\f\024\n 320\ 0 \020, 7\2268)Tj /Span<>> BDC ( )Tj EMC (\002\026\035\035\024\r \023\024)Tj /Span<>> BDC ( )Tj EMC [(\001\022\026\035\036)4( )]TJ -0.004 Tw T* (\202\023\020\026\030.)Tj 0 Tc 0.034 Tw T* (\215\026\006\017\036\027\021\022\026 \023\024\035\031\004\017\035\026 \b\ \017\n\017\024\035\031\004\036\r\024\036 \035\036\004\036\027\017\036 \023\ \024)Tj /Span<>> BDC ( )Tj EMC (\030\026\007\017)Tj 0 Tw (-)Tj 0.09 Tw T* (\022\026\035\034\027\024\005 \023\030\024\020\030\026\n\n\036 \r)Tj /Span<>> BDC ( )Tj EMC (\031\f\035\024\r\017\016\b \230\024\n\f\022\024\020\024 \024\002\035\026\ \f\021\027\024\020\024 )Tj 0.18 Tw 0 -1.218 TD (\024\027\022\024\035\024\020\017\004\036\f\022\024\020\024 \007\017\f\023\ \026\027\f\036\030\026, \023\036\030\036\027\036\f\035\026 \031\007\024\r\ \035\036\021\r\024)Tj 0 Tw (-)Tj 0 -1.218 TD (\030\017\021\036\035\034\027\024, \002\036 \023\026\021\024\035\024\020\ \017\004\036\f\022\017\b \024\f\024\002\036\027\027\024\f\021\036\005.)Tj 0.511 Tw T* (\200 \027\026\f\021\024\016\013\036\036 \r\030\036\n\016 \f\030\024\022 \ \027\026\002\035\033\007\036\027\017\016 \f\024\f\021\026\r\035\016)Tj 0 Tw (-)Tj 0.263 Tw T* (\036\021 2)Tj /Span<>> BDC ( )Tj EMC (\020\024\007\026, \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\022\024\027\021\030\024\035\034\027\024\n \024\002\f\035\036\007\024\r\026\ \027\017\017 \007\026\027\027\t\b )Tj 0.02 Tw T* (\026)Tj /Span<>> BDC ( )Tj EMC (\030\036\006\017\007\017\r \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\022\017 \027\036 \023\024\035\031\004\036\027\ \024. \217\036\002\036\027\024\022 \030\026\f\021\036\021 )Tj 0 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\030\026\r\017\r\026\036\021\f\016 \f\024\024\021\r\036\021\f\021\r\036\ \027\027\024 \r\024\030\026\f\021\031.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 275.0305 554.3378 Tm [(\020)21(\026\027\r\242\224\034\022\031\034)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0.004 Tc 0.151 Tw 10 0 0 10 274.9606 529.9818 Tm (\200 \006\036\035\024\n \023\030\024\020\027\024 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\022\024\035\024\030\036\022\021\026\035\034\027\024\n \030\026\022\036 \ \031)Tj /Span<>> BDC ( )Tj EMC (\002\036\030\036)Tj 0 Tc 0 Tw (-)Tj 0.004 Tc 0.28 Tw T* [(\n\036\027\027\t\b )0.5(\027\036\002\035\026\020\024\023\030\017\016\021\027\t\005, )0.5(\004\021\024 )0.5(\f\r\016\026\027\024 \f)]TJ /Span<>> BDC ( )Tj EMC 18.4 0 Td (\027\036\f\r\024\036\r)Tj 0 Tc 0 Tw (-)Tj 0.004 Tc 0.257 Tw -18.4 -1.218 Td (\030\036\n\036\027\027\024\f\021\034\033 \007\017\026\020\027\024\f\021\017\ \022\017, \021\026\022 \022\026\022 \007\017\026\020\027\024 \031)Tj /Span<>> BDC ( )Tj EMC (\027\026)Tj 0 Tc 0 Tw (-)Tj 0.004 Tc 0.776 Tw T* [(\004\017\021\036\035\034\027\024\020\024 \004\017\f\035\026 \002\036\030\ \036\n\036\027\027\t\b \031\f\021\026\027\026\r\035\017\r\026\036\021\f\016\ )4( )]TJ 0.217 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC [(\007\026\035\036\022\024 \026\001\036\007\001\036\005 \f\021\026\007\017\ \017 \026\002\024\035\036\r\026\027\017\016. \200\024\023\030\024\f\t,)4( )]TJ 0.264 Tw T* [(\022\026\f\026\033\013\017\036\f\016 )0.5(\021\026\022\021\017\022\017 )0.5(\r\036\007\036\027\017\016 )0.5(\002\036\030\036\n\036\027\027\024\f\021\017 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 20.66 0 Td (\r\t)Tj 0 Tc 0 Tw (-)Tj 0.004 Tc 0.122 Tw -20.66 -1.218 Td (\002\024\030\026 \n\036\021\024\007\026 \035\036\004\036\027\017\016 \035\ \024\022\026\004\036\f\021\r\036\027\027\024\005 \024\023\031\b\024\035\017\ , \f\024)Tj 0 Tc 0 Tw (-)Tj 0.004 Tc 0.075 Tw T* (\004\036\021\026\033\013\036\005\f\016 \f)Tj /Span<>> BDC ( )Tj EMC [(\002\036\030\036\n\036\027\027\024\f\021\034\033, \004\030\036\r\t\004\026\ \005\027\024 \f\035\024\032\027\t)4( )]TJ 0.103 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC 0.861 0 Td [(\021\030\031\007\027\024 )0.5(\030\026\030\036\001\017\n\t. )0.5(\204\t )0.5(\023\030\036\007\f\021\026\r\017\035\017 )0.5(\f\024\002\f\021\r\036\027\027\t\005)4( )]TJ 0.152 Tw -0.861 -1.218 Td (\024\023\t\021 \031\f\023\036\001\027\024\020\024 \035\036\004\036\027\017\ \016 \023\026\006\017\036\027\021\024\022 \f)Tj /Span<>> BDC ( )Tj EMC (\022\024\035\024\030\036\022\021\026\035\034)Tj 0 Tc 0 Tw (-)Tj 0.004 Tc 0.103 Tw T* [(\027\t\n )0.5(\030\026\022\024\n )0.5(\027\026)]TJ /Span<>> BDC ( )Tj EMC [(\235\024\027\036 )0.5(\002\036\030\036\n\036\027\027\024\f\021\017 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC [(\r\017\007\036 )0.5(\007\r\031\b \022\035\017)]TJ 0 Tc 0 Tw (-)Tj 0.004 Tc 0.11 Tw T* (\027\017\004\036\f\022\017\b \027\026\002\035\033\007\036\027\017\005. \215\ \024\022\026\026\035\017, \004\021\024 \r)Tj /Span<>> BDC ( )Tj EMC [(\021\036\b \f\035\031\004\026\016\b,)4( )]TJ 0.353 Tw T* [(\022\024\020\007\026 \007\017\026\020\027\024 \022\024\035\024\030\036\022\ \021\026\035\034\027\024\020\024 \030\026\022\026 \f\021\026\r\017\021\f\ \016 \r\024)4( )]TJ 0.482 Tw T* [(\r\030\036\n\016 \002\036\030\036\n\036\027\027\024\f\021\017, \007\035\016\ \023\030\017\027\016\021\017\016 \023\030\026\r\017\035\034\027\024\020\ \024)4( )]TJ 0.369 Tw T* [(\030\036\001\036\027\017\016 \027\036\024\002\b\024\007\017\n \n\036\032\ \007\017\f\006\017\023\035\017\027\026\030\027\t\005 \023\024\007\b\024\007\ .)4( )]TJ 0.078 Tw T* (\200)Tj /Span<>> BDC ( )Tj EMC 0.864 0 Td [(\023\030\017\027\016\021\017\017 )0.6(\030\036\001\036\027\017\016 )0.5(\006\036\035\036\f\024\024\002\030\026\027\024 )0.5(\031\004\026\f\021\017\036 )0.5(\026\022\031\001\036)]TJ 0 Tc 0 Tw (-)Tj 0.004 Tc 0.184 Tw -0.864 -1.218 Td (\030\026, \023\036\030\017\027\026\021\024\035\024\020\026, \022\024\035\ \024\030\036\022\021\026\035\034\027\024\020\024 \b\017\030\031\030\020\026\ , \030\026\007\017\024)Tj 0 Tc 0 Tw (-)Tj 0.004 Tc T* (\035\024\020\026 \017)Tj /Span<>> BDC ( )Tj EMC (\b\017\n\017\024\021\036\030\026\023\036\r\021\026.)Tj /T1_3 1 Tf 0 Tc 0.023 Tw 0 -2.436 TD (\223\030\032\255\020\034\036 \032\026\020\017\022\017\026)Tj /T1_1 1 Tf 0.033 Tw 0 -1.218 TD [(\025)-4.1(\024)-4.3(\027)1.7(\006)-6(\036)-6.8(\023)2.2(\006)-6(\017)-5.4(\016 \017)]TJ /Span<>> BDC ( )Tj EMC 5.622 0 Td [(\007)-6(\017)2.7()-9.9(\026\005)1.7(\027 )0.5(\017)-2.4(\f)3.1(\f)-38.9(\035)-6.8(\036)-18.9(\007)-4.4(\024)-4.3(\r)-8.9(\026\027)1.7(\017)-5.5(\016)13.7(:)]TJ /T1_4 1 Tf -0.01 Tc 0.043 Tw [( )0.5(\224)2.2(\031)-10.9(\032)-4.6(\021)-2.3(\020\001)-6.7(\n\027)-7.9(\026)]TJ /Span<>> BDC 14.322 0 Td ( )Tj EMC 0.266 0 Td [(\201)-12.3(.)-17.8(\035)15(.)-2.2(,)-9.9( )]TJ 0.01 Tw -20.209 -1.218 Td [(\224)2.2(\031)-10.9(\032)-4.6(\021)4.6(\002)0.8(\013\n\027)]TJ /Span<>> BDC 3.783 0 Td ( )Tj EMC [(\201)-12.3(.)-2.7(\201)-12.3(.)]TJ /T1_1 1 Tf 0 Tc 0.633 Tw -3.783 -1.218 Td [(\221)-4.6(\002)-9.9(\024)0.7(\030 \017)]TJ /Span<>> BDC ( )Tj EMC [(\024)-11.8(\002)3(\030)-11.4(\026)-6.3(\002)-9.9(\024)-10.9(\021)-17.6(\022)-19.1(\026 \n)1.3(\026)-11.8(\021)-9.9(\036)-1.7(\030)-7.6(\017)-0.6(\026)-33.1(\035)-2.5(\024)-4.3(\r)10.4(:)]TJ /T1_4 1 Tf -0.01 Tc 0.643 Tw [( \240\026)-8.1(\032)-4.1(\013\n\027)-4.5(\025)9.4(\006)]TJ /Span<>> BDC 19.408 0 Td ( )Tj EMC [(\216)14.3(.)-2.7(\201)-12.2(.)-2.2(,)-10( )]TJ 0 Tc 0 Tw -19.408 -1.218 Td [(\220)49.2(\032)10.2(\205)11.7(\211)-38.1(\205)8.8(\013)]TJ /Span<>> BDC ( )Tj EMC [(\223)26.7(.)20.1(\240)19.4(.)7.8(, \200)11.4(\025)-2.3(\023)11.6(\022)]TJ /Span<>> BDC ( )Tj EMC [(\255)27.7(.)43.7(\207)-2.1(.)]TJ /T1_1 1 Tf 0.002 Tc 0.079 Tw T* [(\203)7.2(\026\023)4.2(\017\f)-10.8(\026)1.7(\027)3.7(\017)-6.7(\036)2.1( \021)-7.9(\036)-3.4(\022\f)-34(\021)-19.5(\026)5.7(:)]TJ /T1_4 1 Tf -0.01 Tc 0.091 Tw 7.775 0 Td [( \224)2.2(\031)-10.9(\032)-4.6(\021)-2.3(\020\001)-6.7(\n\027)-7.9(\026)]TJ /Span<>> BDC 5.026 0 Td ( )Tj EMC [(\201)-12.3(.)-17.8(\035)15(.)-2.2(,)-9.9( \224)2.2(\031)-10.9(\032)-4.6(\021)-2.3(\020\001)-6.7(\n\027)-7.8(\026)]TJ /Span<>> BDC 7.242 0 Td ( )Tj EMC [(\201)-12.3(.)20.3(\036)12.8(.)-2.2(,)-9.9( )]TJ 0.01 Tw -20.043 -1.218 Td [(\224)2.2(\031)-10.9(\032)-4.6(\021)4.6(\002)0.8(\013\n\027)]TJ /Span<>> BDC 3.783 0 Td ( )Tj EMC [(\201)-12.3(.)-2.7(\201)-12.3(.)]TJ /T1_1 1 Tf 0 Tc 0 Tw -3.783 -1.218 Td [(\217)5.5(\036)-19(\007)-20.1(\026\022)-32.6(\021)-17.7(\017)1.5(\030)-11.8(\024)-4.4(\r)-8.8(\026\027)1.8(\017)-8.7(\036)6.5(:)]TJ /T1_4 1 Tf -0.01 Tc 0.278 Tw [( \222\032)-7(\026)-9.6(\t)-3.5(\025)-12.3(\023)1.6(\022)1.3(\021\025)-2.3(\013\n\027)]TJ /Span<>> BDC 13.286 0 Td ( )Tj EMC [(\207)-12.1(.)-6.3(\230)29.2(.)-2.2(,)-10( \201)-1.7(\032)-8(\004)-2.6(\025)-2.3(\033)-5.5(\n\027)-7.9(\026)]TJ /Span<>> BDC 6.46 0 Td ( )Tj EMC [(\243)17(.)19.3(\215)18.9(.)-2.2(,)-10( )]TJ -0.007 Tc 0.007 Tw -19.746 -1.218 Td [(\231)-2(\205\003)-3(\031)-4.3(\017)0.7(\013)5.7(\025\021)2.5(\026)]TJ /Span<>> BDC 4.629 0 Td ( )Tj EMC [(\201)-9.3(.)36.7(\255)20.6(.)]TJ /T1_3 1 Tf 0 Tc 0.023 Tw -4.629 -2.436 Td (AUTHORS CONTRIBUTION)Tj /T1_1 1 Tf -0.047 Tw T* [(C)-6.5(o)0.8(nce)-0.7(p)-12.3(t a)2.4(n)-4.6(d d)-5.5(e)-13.3(s)-16.6(i)3.3(g)1.2(n o)-2.2(f t)-16.7(h)-5.3(e s)-20(t)-12.8(ud)-10.9(y)-11.8(:)]TJ /T1_4 1 Tf [( A)3.7(l)11(y)0.9(on)4.8(a)]TJ /Span<>> BDC ( )Tj EMC [(L)-8.8(.)]TJ /Span<>> BDC ( )Tj EMC [(C)3.2(h)1.9(e)-1.7(r)-14.6(n)6.2(y)-1(s)9.7(h)1.8(ov)10.8(a)-14(, )]TJ 0.001 Tc -0.001 Tw T* [(A)4.6(l)5.8(e)-27.6(x)6.1(ande)-0.7(r)]TJ /Span<>> BDC 3.884 0 Td ( )Tj EMC [(A)-11.6(.)]TJ /Span<>> BDC 1.08 0 Td ( )Tj EMC [(C)4.2(h)2.9(e)-0.7(r)-13.5(n)7.2(y)4.8(a)2.7(k)13.9(ov)]TJ /T1_1 1 Tf 0 Tc 1.014 Tw -4.964 -1.218 Td [(C)-6.5(o)-5.8(l)-19(l)-14.3(e)-9.4(c)-32.5(t)-37.3(i)3.2(o)0.8(n )0.5(a)2.4(n)-4.6(d )0.6(p)-3.8(r)-6(o)-7(ce)-13.3(s)-12.8(s)-16.6(i)7.1(n)-1.9(g )0.6(o)-2.2(f )0.6(t)-16.7(h)-5.3(e )0.5(m)1.8(a)-8.4(t)-15.1(e)-2.1(r)-48(i)5.1(a)-1.5(l)-22.5(:)]TJ /T1_4 1 Tf 0 Tw ( )Tj T* [(V)-5.5(i)0.9(t)2.3(al)4.3(iy)]TJ /Span<>> BDC ( )Tj EMC [(A)-12.6(.)]TJ /Span<>> BDC ( )Tj EMC [(M)5.2(ar)-2.5(k)13(o)-0.6(v)-28.6(i)2.6(c)1.8(h)-6(, Y)33.7(u)2.8(l)4.3(i)5.9(a)]TJ /Span<>> BDC ( )Tj EMC [(M)5.4(.)]TJ /Span<>> BDC ( )Tj EMC [(T)51.2(r)-5(us)9.6(h)8.2(u)4.6(k)-17.3(, O)-7.4(l)4.7(ga)]TJ /Span<>> BDC ( )Tj EMC [(S)2.1(.)]TJ /Span<>> BDC ( )Tj EMC [(D)-7.9(i)7.4(l)]TJ /T1_1 1 Tf 0.841 Tw T* [(W)3.1(r)-48(i)-6(t)-37.4(i)7.1(n)-1.9(g o)-2.1(f t)-16.7(h)-5.3(e t)-15.2(e)-23.9(x)-36(t)-20.1(:)]TJ /T1_4 1 Tf [( A)3.6(l)11(y)1(on)4.8(a)]TJ /Span<>> BDC ( )Tj EMC [(L)-8.8(.)]TJ /Span<>> BDC ( )Tj EMC [(C)3.2(h)1.9(e)-1.7(r)-14.6(n)6.2(y)-0.9(s)9.6(h)1.8(ov)10.8(a)-14(, )]TJ 0.001 Tc -0.001 Tw T* [(A)5.8(r)-34.3(i)9.5(n)5.8(a)]TJ /Span<>> BDC 2.106 0 Td ( )Tj EMC [(E)20.8(.)]TJ /Span<>> BDC 0.987 0 Td ( )Tj EMC [(C)4.2(h)2.9(e)-0.7(r)-13.5(n)7.2(ys)10.6(h)2.9(ov)11.8(a)-13(,)1.1( A)4.6(l)5.8(e)-27.6(x)6(ande)-0.7(r)]TJ /Span<>> BDC 9.41 0 Td ( )Tj EMC [(A)-11.6(.)]TJ /Span<>> BDC 1.08 0 Td ( )Tj EMC [(C)4.2(h)2.9(e)-0.7(r)-13.5(n)7.2(y)4.8(a)2.7(k)13.9(ov)]TJ /T1_1 1 Tf 0.006 Tc -0.006 Tw -13.583 -1.218 Td [(E)11.6(dit)-31.4(i)13.1(n)4.1(g)15(:)]TJ /T1_4 1 Tf 0 Tc 0.522 Tw 3.238 0 Td [( S)5.6(e)-1.7(r)2.3(g)-2.5(e)-2.5(y)]TJ /Span<>> BDC ( )Tj EMC [(E)19.8(.)]TJ /Span<>> BDC ( )Tj EMC [(K)1.7(r)7.7(a)-3(s)-8.3(i)7.4(l)-5.9(n)6.2(i)8(k)12.9(o)-0.6(v)33.6(, Y)39.3(a)-0.8(n)4.8(a)]TJ /Span<>> BDC ( )Tj EMC [(I)2.4(.)]TJ /Span<>> BDC ( )Tj EMC [(A)4.8(r)-2.5(k)5.3(h)6.2(i)5.8(p)-4.9(o)-0.6(v)10.8(a)-14(, )]TJ -0.008 Tc 0.008 Tw -3.238 -1.218 Td [(A)-4.2(n)-3.2(a)-11(s)-18.7(t)-5.6(a)-11(s)-16.3(i)-2.1(a)]TJ /Span<>> BDC 3.821 0 Td ( )Tj EMC [(O)5.1(.)]TJ /Span<>> BDC 1.053 0 Td ( )Tj EMC [(S)7.3(hu)-2.9(m)-9(e)-10(ik)-26.5(in)-3.2(a)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 0 Tc 0 Tw 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\033\030\031\030\213\b)-20.9(\035\231\213\233\t \021\032)50(\b)42(\032\231\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj /T1_5 1 Tf 25 0 0 25 505.4397 56.0378 Tm (105)Tj ET endstream endobj 1466 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.065 Tw 10 0 0 10 70.8661 724.8299 Tm [(\r\022\035\033\004\026\033\013\017\005 )0.5(\023\030\036\r\030\026\013\036\027\017\036 )0.5(\022\026\022 \r)]TJ /Span<>> BDC ( )Tj EMC [(\036\020\024 )0.5(\026\022\021\017\r\027\t\005 \n\036\021\026)]TJ 0 Tw (-)Tj 0.081 Tw 0 -1.218 TD (\002\024\035\017\021 \(SN38\) \023\024\007 \007\036\005\f\021\r\017\036\n\ \022\026\030\002\024\022\f\017\035\220\f\021\036\030\026\t, \021\026\022\ )Tj -0.056 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\r \027\036\026\022\021\017\r\027\t\036 \n\036\021\026\002\024\035\017\021\ \t \023\024\f\030\036\007\f\021\r\024\n CYP3A4 [49]. )Tj 0.045 Tw T* (SN38 \022\024\027\255\033\020\017\030\031\036\021\f\016 \f)Tj /Span<>> BDC ( )Tj EMC [(\023\024\n\024\013\034\033 UG)-12(T1A1 \f)]TJ /Span<>> BDC ( )Tj EMC (SN38G, \020\024)Tj 0 Tw (-)Tj 0.237 Tw T* [(\030\026\007\024 )0.5(\n\036\027\036\036 )0.6(\026\022\021\017\r\027\024\005 )0.5(\235\024\030\n\024\005. )0.6(\222\030\017\027\024\021\036\022\026\027 )0.5(\n\024\032\036\021 )]TJ 0.078 Tw T* (\017\n\036\021\034 \031\r\036\035\017\004\036\027\027\t\005 \022\035\017\ \030\036\027\f \023\030\036\023\026\030\026\021\026 \r\024 \r\030\036\n\016\ \002\036)Tj 0 Tw (-)Tj 0.406 Tw 0 -1.218 TD (\030\036\n\036\027\027\024\f\021\017, \026\027\026\035\024\020\017\004\027\ \t\005 \021\026\022\024\r\024\n\031 \031)Tj /Span<>> BDC ( )Tj EMC (\035\026\002\036\021\026\035\024\035\026, )Tj 0.065 Tw 0 -1.218 TD (\031)Tj /Span<>> BDC ( )Tj EMC (\022\024\021\024\030\024\020\024 \023\024\r\t\001\036\027\027\t\005 \022\ \035\017\030\036\027\f \022\024\030\030\036\035\017\030\031\036\021 \f)Tj /Span<>> BDC ( )Tj EMC (\031\f\017)Tj 0 Tw (-)Tj 0.296 Tw T* [(\035\036\027\017\036\n \030\036\020\031\035\016\006\017\017 )0.5(UG)-12(T1A1 [20\22622]. \210\020\030\026\027\017\004\036\027\027\t\036 )]TJ 0.757 Tw T* (\235\026\030\n\026\022\024\022\017\027\036\021\017\004\036\f\022\017\036\ \024\006\036\027\022\017 \b\017\n\017\024\021\036\030\026\023\017\017 \r\ \024 )Tj 0.095 Tw T* (\r\030\036\n\016 \002\036\030\036\n\036\027\027\024\f\021\017 \017)Tj /Span<>> BDC ( )Tj EMC [(\235\017\017\024\035\024\020\017\004\036\f\022\017\036 )0.5(\017\n\036\027\036\027\017\016, )]TJ 0.229 Tw T* (\023\030\024\017\f\b\024\007\016\013\017\036 \r\024 \r\030\036\n\016 \002\ \036\030\036\n\036\027\027\024\f\021\017, \026\021\030\031\007\027\016\033\ \021 )Tj 0.402 Tw 0 -1.218 TD [(\220\022\f\021\030\026\023\024\035\016\006\017\033 \220\021\017\b )0.5(\017\n\036\027\036\027\017\005 \023\030\017)]TJ /Span<>> BDC ( )Tj EMC (\024\023\030\036\007\036\035\036\027\017\017 )Tj 0 Tw 0 -1.218 TD (\007\024\t, \n\036\021\026\002\024\035\017\n\026 \017)Tj /Span<>> BDC ( )Tj EMC (\022\035\017\030\036\027\f\026.)Tj 0.282 Tw 0 -1.218 TD [(\214\031\004\036\r\026\016 )0.5(\021\036\030\026\023\017\016 \021\026\026 )0.5(\027\036 \030\036\022\024\n\036\027\007\031\036\021\f\016 )0.5(\r\024 \r\030\036\n\016 )]TJ 0.121 Tw T* (\002\036\030\036\n\036\027\027\024\f\021\017 \017-\026 \023\024\021\036\ \027\006\017\026\035\034\027\024\020\024 \r\030\036\007\026 \007\035\016\ \023\035\024)Tj 0 Tw (-)Tj 0.083 Tw T* (\007\026 [19,23,24]. \204\024\032\027\024 \030\026\f\f\n\024\021\030\036\ \021\034 \r\024\n\024\032\027\024\f\021\034 \023\030\024)Tj 0 Tw (-)Tj 0.238 Tw T* [(\r\036\007\036\027\017\016 \035\031\004\036\r\024\005 \021\036\030\026\023\ \017\017 )0.5(\021\026\026 \023\024\f\035\036 \030\024\007\024\r, \027\024 \036\036 )]TJ 0.043 Tw T* (\f\035\036\007\031\036\021 \024\002\f\031\007\017\021\034 \f)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\022\024\005, \023\024\f\022\024\035\034\022\ \031 \220\021\024 \n\024\032\036\021 )Tj 0 Tw T* (\023\030\017\r\036\f\021\017 \022)Tj /Span<>> BDC ( )Tj EMC (\002\036\f\023\035\024\007\017\033 [25,26].)Tj 0.344 Tw T* (\215\f\017\b\024\035\024\020\017\004\036\f\022\026\016 \030\036\026\022\006\ \017\016 \002\036\030\036\n\036\027\027\024\005 \027\026)Tj /Span<>> BDC ( )Tj EMC (\007\017\026\020\027\024 )Tj -0.022 Tw T* (\025\217\217 \r\f\036\020\007\026 \023\036\f\f\017\n\017\f\021\017\004\027\ \026, \027\024 \027\026\017\002\024\035\036\036 \021\016\032\036\035\024\ \002\024\035\034)Tj 0 Tw (-)Tj 0.114 Tw T* (\027\026\016 \023\036\030\036\027\024\f\017\021 \017\r\036\f\021\017\036\ \024)Tj /Span<>> BDC ( )Tj EMC (\027\036\024\002\b\024\007\017\n\024\f\021\017 \235\024\030\n\017\030\024\ )Tj 0 Tw (-)Tj 0.056 Tw T* [(\r\026\027\017\016 )0.5(\022\024\035\024\f\021\024\n\t. )0.6(\200)]TJ /Span<>> BDC ( )Tj EMC 8.585 0 Td [(\021\026\022\017\b )0.5(\f\035\031\004\026\016\b, )0.6(\027\036\f\n\024\021\030\016 )0.6(\027\026)]TJ /Span<>> BDC ( )Tj EMC 11.625 0 Td (\f\030\024\022 )Tj 0.393 Tw -20.21 -1.218 Td (\002\036\030\036\n\036\027\027\024\f\021\017, \n\027\024\020\017\036 \023\ \026\006\017\036\027\021\022\017 \027\036 \f\024\020\035\026\001\026\033\ \021\f\016 )Tj 0.202 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\007\017\026\020\027\024\024\n, \022\026\021\036\020\024\030\017\004\036\ \f\022\017 \024\021\022\026\t\r\026\033\021\f\016 \024\021 \023\030\036\ \007)Tj 0 Tw (-)Tj 0.084 Tw T* (\035\024\032\036\027\027\024\020\024 \035\036\004\036\027\017\016 \023\024\ )Tj /Span<>> BDC ( )Tj EMC (\023\024\r\024\007\031 \030\026\022\026 \007\024)Tj /Span<>> BDC ( )Tj EMC (\021\036\b \023\024\030, \023\024\022\026 )Tj -0.036 Tw T* (\023\035\024\007 \027\036 \f\021\026\027\036\021 \032\017\027\036\f\023\ \024\f\024\002\027\t\n. \230\016\032\036\035\026\016 \023\f\017\b\024\035\ \024\020\017)Tj 0 Tw (-)Tj -0.02 Tw T* (\004\036\f\022\026\016 \026\021\n\024\f\235\036\030\026 \021\030\036\002\ \031\036\021 \024\021 \r\030\026\004\026 \r\t\030\026\002\024\021\022\017\ \004\036\021\022\024\005 )Tj 0.092 Tw T* (\021\026\022\021\017\022\017 \r\036\007\036\027\017\016 \002\036\030\036\ \n\036\027\027\024\f\021\017 \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\f\021\026\r\035\036\027\017\016 \023\035\026\027\026 )Tj 0.083 Tw T* (\030\024\007\024\030\026\030\036\001\036\027\017\016 \f)Tj /Span<>> BDC ( )Tj EMC (\023\024\f\035\036\007\031\033\013\036\005 \030\026\030\026\002\024\021\ \022\024\005 \f\b\036\n\t )Tj 0.044 Tw T* (\035\036\004\036\027\017\016. \210\f\024\002\036\027\027\024 \220\021\024\ \022\026\f\026\036\021\f\016 \021\036\b \022\035\017\027\017\004\036\f\022\ \017\b \f\017)Tj 0 Tw (-)Tj 0.121 Tw T* (\021\031\026\006\017\005, \022\024\020\007\026 \031)Tj /Span<>> BDC ( )Tj EMC (\002\036\030\036\n\036\027\027\024\005 \027\036\021 \024\013\031\013\036\ \027\017\016 \002\024\035\036\027\017, )Tj 0.028 Tw T* (\036\036 \024\006\036\027\022\017, \r)Tj /Span<>> BDC ( )Tj EMC (\f\r\016\017 \f)Tj /Span<>> BDC ( )Tj EMC (\004\036\n \024\027\026 \f\021\030\036\n\017\021\f\016 \023\f\017\b\024\035\ \024\020\017\004\036)Tj 0 Tw (-)Tj -0.033 Tw T* (\f\022\017 \253\024\021\020\024\030\024\007\017\021\034\f\016\273 \024\021\ \027\036\f\004\026\f\021\034\016. \200)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\024\n \f\035\031\004\026\036 \r\030\026\004 )Tj 0.021 Tw T* (\027\036 \r\f\036\020\007\026 \n\024\032\036\021 \031\002\036\007\017\021\ \034 \023\026\006\017\036\027\021\022\031 \r)Tj /Span<>> BDC ( )Tj EMC (\027\036\024\002\b\024\007\017\n\024\f\021\017 )Tj -0.03 Tw T* (\027\036\026\n\036\007\035\017\021\036\035\034\027\024\020\024 \035\036\ \004\036\027\017\016, \023\024\f\022\024\035\034\022\031 \027\026)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\r\024\036 \n\036)Tj 0 Tw (-)Tj T* (\f\021\024 \024\027\026 \f\021\026\r\017\021 \017\027\021\036\030\036\f\t\ \023\035\024\007\026 [27\22629].)Tj -0.014 Tw T* (\230\026\022\017\n \024\002\030\026\024\n, \r)Tj /Span<>> BDC ( )Tj EMC (\021\036\b \f\035\031\004\026\016\b, \022\024\020\007\026 \007\017\026\020\ \027\024 \022\024\035\024\030\036\022)Tj 0 Tw (-)Tj 0.117 Tw T* [(\021\026\035\034\027\024\020\024 )0.5(\030\026\022\026 \f\021\026\r\017\021\f\016 )0.5(\r\024 \r\030\036\n\016 )0.5(\002\036\030\036\n\036\027\027\024\f\021\017, )0.5(\007\035\016 )]TJ 0.119 Tw T* (\023\030\017\027\016\021\017\016 \023\030\026\r\017\035\034\027\024\020\024\ \030\036\001\036\027\017\016, \031\f\023\036\001\027\024\020\024 \035\036\ \004\036\027\017\016 )Tj 0.046 Tw T* [(\027\036\024\002\b\024\007\017\n \n\036\032\007\017\f\006\017\023\035\017\ \027\026\030\027\t\005 )0.5(\023\024\007\b\024\007. \200)]TJ /Span<>> BDC ( )Tj EMC (\023\030\017\027\016\021\017\017 )Tj 0.07 Tw T* [(\030\036\001\036\027\017\016 \006\036\035\036\f\024\024\002\030\026\027\ \024 )0.5(\031\004\026\f\021\017\036 \026\022\031\001\036\030\026, \023\036\030\017\ \027\026\021\024)]TJ 0 Tw (-)Tj -0.007 Tw T* (\035\024\020\026, \022\024\035\024\030\036\022\021\026\035\034\027\024\020\ \024 \b\017\030\031\030\020\026, \030\026\007\017\024\035\024\020\026 \017\ )Tj /Span<>> BDC ( )Tj EMC (\b\017\n\017\024\021\036)Tj 0 Tw (-)Tj T* (\030\026\023\036\r\021\026, \n\036\007\017\006\017\027\f\022\024\020\024\ \023\f\017\b\024\035\024\020\026 [30\22633].)Tj 0.375 Tw T* (\215\030\036\007\f\021\026\r\035\016\036\n \007\r\026 \022\035\017\027\017\ \004\036\f\022\017\b \f\035\031\004\026\016 \031\f\023\036\001\027\024\020\ \024 )Tj 0.025 Tw T* (\035\036\004\036\027\017\016 \023\026\006\017\036\027\021\024\022 \f)Tj /Span<>> BDC ( )Tj EMC (\022\024\035\024\030\036\022\021\026\035\034\027\t\n \030\026\022\024\n \ \027\026)Tj /Span<>> BDC ( )Tj EMC (\235\024\027\036 )Tj 0 Tw T* (\002\036\030\036\n\036\027\027\024\f\021\017.)Tj /T1_1 1 Tf 0.023 Tw 0 -2.436 TD (\021\f\t\b\t\201\r\217\220\t\005 \212\006\t\214\r\006 \2321)Tj /T1_0 1 Tf -0.033 Tw 0 -1.218 TD (\215\026\006\017\036\027\021\022\026 \217, 33 \035\036\021 \023\024\f\021\ \031\023\017\035\026 \r)Tj /Span<>> BDC ( )Tj EMC (\210\210\212 \020.)Tj /Span<>> BDC ( )Tj EMC (\230\024\n\f\022\026 \r)Tj /Span<>> BDC ( )Tj EMC (\026\023\030\036)Tj 0 Tw (-)Tj 0.132 Tw T* (\035\036 2016 \020. \023\024)Tj /Span<>> BDC ( )Tj EMC (\027\026\023\030\026\r\035\036\027\017\033 \017)Tj /Span<>> BDC ( )Tj EMC (\230\024\n\f\022\024\020\024 \024\002\035\026\f\021\027\024\020\024 )Tj 0.151 Tw T* (\023\036\030\017\027\026\021\026\035\034\027\024\020\024 \006\036\027\021\ \030\026 \f)Tj /Span<>> BDC ( )Tj EMC (\002\036\030\036\n\036\027\027\024\f\021\034\033 31\22632)Tj /Span<>> BDC ( )Tj EMC (\027\036)Tj 0 Tw (-)Tj -0.012 Tw T* (\007\036\035\034. \203\026)Tj /Span<>> BDC ( )Tj EMC (\n\024\n\036\027\021 \023\024\f\021\031\023\035\036\027\017\016 \023\026\ \006\017\036\027\021\022\026 \023\030\036\007\255\016\r\035\016\035\026 \ )Tj 0.274 Tw 23.244 64.543 Td (\032\026\035\024\002\t \027\026)Tj /Span<>> BDC ( )Tj EMC (\021\024\001\027\024\021\031, \030\r\024\021\031, \027\024\033\013\017\036\ \021\016\027\031\013\017\036 \002\024\035\017 )Tj 0.141 Tw T* (\r\027\017\031 \032\017\r\024\021\026, \r\007\031\021\017\036 \032\017\ \r\024\021\026, \026)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\032\036 \027\026\035\017\004\017\036 \026)Tj 0 Tw (-)Tj 0.045 Tw T* (\023\024\030\024\r \r)Tj /Span<>> BDC ( )Tj EMC (\021\036\004\036\027\017\036 \023\024\f\035\036\007\027\036\020\024 \n\036\ \f\016\006\026. \215\024)Tj /Span<>> BDC ( )Tj EMC (\211\003\222 \024\030\020\026\027\024\r )Tj 0.009 Tw T* (\n\026\035\024\020\024 \021\026\026 \017)Tj /Span<>> BDC ( )Tj EMC (\002\030\033\001\027\024\005 \023\024\035\024\f\021\017)Tj /Span<>> BDC ( )Tj EMC (\227 \024\007\017\027 \032\017\r\024\005 \023\035\024\007, )Tj 0.405 Tw T* (\023\026\021\024\035\024\020\017\004\036\f\022\017\036 \017\n\036\027\036\ \027\017\016 \024\002\027\026\030\031\032\036\027\t \027\036 \002\t\035\017\ . )Tj 0.091 Tw T* (\215\026\006\017\036\027\021\022\026 \030\026\027\036\036 \023\024\035\031\ \004\026\035\026 \024\f\n\024\021\017\004\036\f\022\017\036 \f\035\026\002\ \017\021\036\035\034)Tj 0 Tw (-)Tj 0.312 Tw 0 -1.218 TD [(\027\t\036 \023\030\036\023\026\030\026\021\t, \n\036\021\024\022\035\024\ \023\030\026\n\017\007, )0.5(\f\023\026\n\024\035\017\021\017\022\017 \002\036 )]TJ 0.225 Tw 0 -1.218 TD (\r\t\030\026\032\036\027\027\024\020\024 \220\235\235\036\022\021\026. \215\ \024)Tj /Span<>> BDC ( )Tj EMC (\026\027\026\035\017\026\n, \017)Tj /Span<>> BDC ( )Tj EMC (\024\f\024\002\036\027\027\024)Tj 0 Tw (-)Tj 0.009 Tw T* (\f\021\036\005: \027\036\005\021\030\024\235\017\035\034\027\t\005 \035\036\ \005\022\024\006\017\021\024 \(\024\002\013\036\036 \022\024\035\017\004\ \036\f\021\r\024 )Tj 0.088 Tw T* (\035\036\005\022\024\006\017\021\024\r 15,6)Tj /Span<>> BDC ( )Tj EMC (\327)Tj /Span<>> BDC ( )Tj EMC (10)Tj 0 Tw 5.83 0 0 5.83 392.7649 618.5578 Tm (9)Tj 0.088 Tw 10 0 0 10 395.6799 615.2278 Tm (, \026\027\036\n\017\016 \035\036\020\022\024\005 \f\021\036\023\036\027\ \017 \021\016\032\036)Tj 0 Tw (-)Tj 0.071 Tw -9.237 -1.218 Td (\f\021\017 \020\036\n\024\020\035\024\002\017\027)Tj /Span<>> BDC ( )Tj EMC (\227 100)Tj /Span<>> BDC ( )Tj EMC (\020/\035. \200)Tj /Span<>> BDC ( )Tj EMC (\023\035\026\027\036 \007\024\024\002\f\035\036\007\024\r\026\027\017\016\ )Tj 0.21 Tw T* [(\002\t\035\026 \023\030\024\r\036\007\036\027\026 \024\002\024\030\027\026\ \016 )0.5(\030\036\027\021\020\036\027\024\020\030\026\235\017\016 )0.5(\024\030\020\026\027\024\r )]TJ 0.102 Tw 0 -1.218 TD (\002\030\033\001\027\024\005 \023\024\035\024\f\021\017, \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\022\024\021\024\030\024\005 \002\t\035\024 \r\t\016\r\035\036\027\024 \030\ \026\f)Tj 0 Tw (-)Tj -0.046 Tw 0 -1.218 TD (\001\017\030\036\027\017\036 \021\024\027\022\024\005 \022\017\001\022\017\ \007\024)Tj /Span<>> BDC ( )Tj EMC (5 \f\n)Tj /Span<>> BDC ( )Tj EMC (\227 \026\023\024\007\024\030\036\027\026 \021\024\027\022\024)Tj 0 Tw (-)Tj 0.012 Tw 0 -1.218 TD (\022\017\001\036\004\027\026\016 \027\036\023\030\024\b\024\007\017\n\024\ \f\021\034. \215\024)Tj /Span<>> BDC ( )Tj EMC (\221\025\230 \024\030\020\026\027\024\r \002\030\033\001\027\024\005 )Tj -0.003 Tw T* (\023\024\035\024\f\021\017 \002\t\035\024 \r\t\016\r\035\036\027\024 \r\t\ \030\026\032\036\027\027\024\036 \r\007\031\021\017\036 \021\024\035\f\021\ \024\005 )Tj 0.108 Tw T* (\022\017\001\022\017 \f)Tj /Span<>> BDC ( )Tj EMC (\021\024\004\022\024\005 \023\036\030\036\b\024\007\026 \n\036\032\007\031\ \030\026\f\021\016\027\031\021\024\005 \017)Tj /Span<>> BDC ( )Tj EMC (\f\023\026\r)Tj 0 Tw (-)Tj -0.043 Tw T* (\001\036\005\f\016 \022\017\001\022\024\005 \r)Tj /Span<>> BDC ( )Tj EMC (\024\002\035\026\f\021\017 \f\017\020\n\024\r\017\007\027\024\005 \022\017\ \001\022\017 \r)Tj /Span<>> BDC ( )Tj EMC (\007\024\023\024\035)Tj 0 Tw (-)Tj 0.145 Tw T* (\027\036\027\017\036 \022)Tj /Span<>> BDC ( )Tj EMC (\030\026\f\001\017\030\036\027\027\024\005 \021\024\027\022\024\005 \022\ \017\001\022\036, \004\021\024 \031\022\026\t\r\026\035\024 )Tj 0.285 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC 1.491 0 Td [(\n\036\b\026\027\017\004\036\f\022\031\033 )0.5(\021\024\035\f\021\024\022\017\001\036\004\027\031\033 )0.6(\027\036\023\030\024\b\024\007\017\n\024\f\021\034 )]TJ -0.034 Tw -1.491 -1.218 Td (\017)Tj /Span<>> BDC ( )Tj EMC (\027\036 \023\024\r\024\035\016\035\024 \017\f\022\035\033\004\017\021\034\ \027\026\035\017\004\017\036 \030\026\022\026 \f\017\020\n\024\r\017\007\ \027\024\005 )Tj 0 Tw T* (\022\017\001\022\017.)Tj 0.29 Tw T* [(\215\030\024\r\036\007\036\027 )0.5(\022\024\027\f\017\035\017\031\n, )0.6(\r)]TJ /Span<>> BDC ( )Tj EMC 10.679 0 Td [(\f\024\f\021\026\r\036 )0.5(\r\030\026\004\036\005 )0.6(\026\022\031\001\036\030\024\r-)]TJ 0.634 Tw -10.679 -1.218 Td [(\020\017\027\036\022\024\035\024\020\024\r, \024\027\022\024\035\024\020\ \024\r, )0.5(\026\027\036\f\021\036\017\024\035\024\020\024\r \017)]TJ /Span<>> BDC ( )Tj EMC (\027\036\024)Tj 0 Tw (-)Tj 0.366 Tw T* [(\027\026\021\024\035\024\020\024\r. )0.6(\215\024\f\035\036 )0.5(\026\027\026\035\017\026 )0.5(\030\017\f\022\024\r )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 16.671 0 Td (\023\030\036\017\n\031\013\036\f\021\r )Tj 0.243 Tw -16.671 -1.218 Td (\024\023\036\030\026\021\017\r\027\024\020\024 \017)Tj /Span<>> BDC ( )Tj EMC (\022\024\027\f\036\030\r\026\021\017\r\027\024\020\024 \035\036\004\036\027\ \017\016, \026)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\032\036 )Tj 0.18 Tw T* (\r\024\n\024\032\027\024\f\021\017 \023\024\021\036\030\017 \023\035\024\ \007\026, \002\t\035\024 \023\030\017\027\016\021\024 \030\036\001\036\027\ \017\036 )Tj 0.104 Tw T* (\024)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\r\036\007\036\027\017\017 \b\017\030\031\030\020\017\004\036\ \f\022\024\020\024 \035\036\004\036\027\017\016 \r)Tj /Span<>> BDC ( )Tj EMC (\024\002\255\036\n\036 \022\036)Tj 0 Tw (-)Tj 0.01 Tw T* (\f\026\030\036\r\026 \f\036\004\036\027\017\016, \030\036\036\022\006\017\ \016 \f\017\020\n\024\r\017\007\027\024\005 \022\017\001\022\017 \f)Tj /Span<>> BDC ( )Tj EMC (\235\024\030)Tj 0 Tw (-)Tj -0.034 Tw T* (\n\017\030\024\r\026\027\017\036\n \f\021\024\n\t. \200)Tj /Span<>> BDC ( )Tj EMC (\030\036\031\035\034\021\026\021\036 \024\023\036\030\026\006\017\017 \253\ \022\036\f\026\030\036\r\024 )Tj 0.057 Tw T* (\f\036\004\036\027\017\036\273 \030\024\007\017\035\f\016 \032\017\r\024\ \005 \023\035\024\007 \n\031\032\f\022\024\020\024 \023\024\035\026, \r\036\ \f\024\n )Tj 0.045 Tw T* (1650 \020, \023\024)Tj /Span<>> BDC ( )Tj EMC (\001\022\026\035\036 \202\023\020\026\030 7\2269)Tj /Span<>> BDC ( )Tj EMC (\002\026\035\035\024\r. \206\017\f\021\024\035\024\020\017\004\036\f\022\ \024\036 )Tj 0.725 Tw T* [(\026\022\035\033\004\036\027\017\036: \031\n\036\030\036\027\027\024\007\ \017\235\235\036\030\036\027\006\017\030\024\r\026\027\027\026\016 )0.5(\026\007\036)]TJ 0 Tw (-)Tj 0.377 Tw T* (\027\024\022\026\030\006\017\027\024\n\026 \f\017\020\n\024\r\017\007\027\ \024\005 \022\017\001\022\017 \030\026\n\036\030\024\n 4)Tj /Span<>> BDC ( )Tj EMC (\f\n )Tj 0.128 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\027\026\017\002\024\035\034\001\036\n \017\n\036\030\036\027\017\017, \ \r)Tj /Span<>> BDC ( )Tj EMC (4 \017)Tj /Span<>> BDC ( )Tj EMC (16 \035\017\n\235\026\021\017\004\036\f\022\017\b )Tj 0.154 Tw T* (\031\035\026\b \002\t\035\017 \024\002\027\026\030\031\032\036\027\t \n\ \036\021\026\f\021\026\t. \230\026\022\017\n \024\002\030\026\024\n, )Tj 0.164 Tw T* (\024\022\024\027\004\026\021\036\035\034\027\t\005 \007\017\026\020\027\024\  \f\235\024\030\n\031\035\017\030\024\r\026\027 \f\035\036\007\031\033\013\ \017\n )Tj 0.172 Tw T* (\024\002\030\026\024\n: \217\026\022 \f\017\020\n\024\r\017\007\027\024\ \005 \022\017\001\022\017 III B: pT3N2a\2040. )Tj 0.517 Tw T* [(\215\030\024\r\036\007\036\027\026 \026\007\255\033\r\026\027\021\027\026\ \016 )0.5(\b\017\n\017\024\021\036\030\026\023\017\016 \023\024)]TJ /Span<>> BDC ( )Tj EMC (\f\b\036\n\036 )Tj 0 Tw T* [(FOLFO)17(X \r)]TJ /Span<>> BDC ( )Tj EMC (\021\036\004\036\027\017\036 6 \n\036\f\016\006\036\r.)Tj 0.069 Tw T* (\200 \027\026\f\021\024\016\013\036\036 \r\030\036\n\016 \023\026\006\017\ \036\027\021\022\026 \027\026\b\024\007\017\021\f\016 \027\026)Tj /Span<>> BDC ( )Tj EMC (\007\017\027\026\n\017)Tj 0 Tw (-)Tj -0.104 Tw T* (\004\036\f\022\024\n \027\026\002\035\033\007\036\027\017\017 \002\036 \ \023\030\017\027\026\022\024\r \030\036\006\017\007\017\r\026. \217\036\ \002\036\027\024\022 )Tj 0 Tw T* (\030\026\f\021\036\021 \017)Tj /Span<>> BDC ( )Tj EMC (\030\026\r\017\r\026\036\021\f\016 \f\024\024\021\r\036\021\f\021\r\036\ \027\027\024 \r\024\030\026\f\021\031.)Tj /T1_1 1 Tf 0.023 Tw 0 -2.436 TD (\021\f\t\b\t\201\r\217\220\t\005 \212\006\t\214\r\006 \2322)Tj /T1_0 1 Tf 0.057 Tw 0 -1.218 TD [(\215\026\006\017\036\027\021\022\026 )0.6(\223, )0.6(33 )0.5(\035\036\021, )0.6(\024\002\030\026\021\017\035\026\f\034 )0.7(\r)]TJ /Span<>> BDC ( )Tj EMC 14.534 0 Td [(\n\026\036 )0.6(2021)]TJ /Span<>> BDC ( )Tj EMC 4.08 0 Td [(\020. )0.6(\022)]TJ /Span<>> BDC ( )Tj EMC 1.706 0 Td (\r\030\026)Tj 0 Tw (-)Tj 0.294 Tw -20.319 -1.218 Td (\004\031-\024\027\022\024\035\024\020\031 \023\024)Tj /Span<>> BDC ( )Tj EMC (\027\026\023\030\026\r\035\036\027\017\033 \r\030\026\004\026 \026\022\031\ \001\036\030\026-\020\017\027\036)Tj 0 Tw (-)Tj 0.33 Tw T* (\022\024\035\024\020\026 \020.)Tj /Span<>> BDC ( )Tj EMC (\025\t\t\035. \215\026\006\017\036\027\021\022\026 \023\030\036\007\255\ \016\r\035\016\035\026 \032\026\035\024\002\t )Tj -0.046 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\017\024\007\017\004\036\f\022\017\036 \027\024\033\013\017\036\ \021\016\027\031\013\017\036 \002\024\035\017 \r\027\017\031 \032\017\r\ \024)Tj 0 Tw (-)Tj 0.091 Tw T* (\021\026, \007\017\f\022\024\n\235\024\030\021 \r)Tj /Span<>> BDC ( )Tj EMC (\024\002\035\026\f\021\017 \026\027\031\f\026 \017)Tj /Span<>> BDC ( )Tj EMC (\022\030\036\f\021\006\026, \022\030\024\r\016\027\017)Tj 0 Tw (-)Tj 0.074 Tw T* [(\f\021\t\036 \r\t\007\036\035\036\027\017\016 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 8.26 0 Td [(\023\030\016\n\024\005 )0.5(\022\017\001\022\017 \023\024\f\035\036 )0.5(\007\036\235\036\022\026\006\017\017. )]TJ 0.057 Tw -8.26 -1.218 Td [(\210\021\n\036\004\026\035\026\f\034 \021\036\027\007\036\027\006\017\016\ )0.5(\022)]TJ /Span<>> BDC ( )Tj EMC (\031\f\017\035\036\027\017\033 \r\t\001\036\023\036\030\036\004\017\f\035\ \036\027)Tj 0 Tw (-)Tj 0.1 Tw T* (\027\t\b \032\026\035\024\002 \026)Tj /Span<>> BDC ( )Tj EMC (\023\024\f\035\036\007\027\017\005 \n\036\f\016\006. \203\026)Tj /Span<>> BDC ( )Tj EMC (\n\024\n\036\027\021 \024\002\030\026\013\036)Tj 0 Tw (-)Tj 0.253 Tw T* (\027\017\016 \032\036\027\013\017\027\026 \f\024\f\021\024\016\035\026 \027\ \026)Tj /Span<>> BDC ( )Tj EMC (\031\004\036\021\036 \023\024)Tj /Span<>> BDC ( )Tj EMC (\002\036\030\036\n\036\027\027\024\f\021\017, )Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0 Tw 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\033\030\031\030\213\b)-20.9(\035\231\213\233\t \021\032)50(\b)42(\032\231\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj -51.938 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 23, \023\0221)69(, 202)69(4)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 23, \023\0221)69(, 202)69(4)]TJ /T1_3 1 Tf 25 0 0 25 20.8528 56.0378 Tm (104)Tj ET endstream endobj 1465 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\037)31(\025\007\025\002\016\n)-10(\026)11(\013\007\216\001\020\203 \002\013\n \220\022\f\016\002\016\024\016\001\001\ \025\006)-10(\026\216)]TJ 47.216 0 Td [(Color)31(ectal cancer and pr)31(egnancy)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0.262 Tw 10 0 0 10 42.5197 724.8299 Tm (\215\030\017)Tj /Span<>> BDC ( )Tj EMC (\023\035\026\027\017\030\024\r\026\027\017\017 \035\036\004\036\027\017\016\ \f\035\036\007\031\036\021 \031\004\017\021\t\r\026\021\034 \027\036)Tj 0 Tw (-)Tj 0.037 Tw 0 -1.218 TD (\f\022\024\035\034\022\024 \235\026\022\021\024\030\024\r: \035\024\022\026\ \035\017\026\006\017\033 \024\023\031\b\024\035\017, \f\030\024\022 \002\ \036\030\036)Tj 0 Tw (-)Tj 0.071 Tw T* (\n\036\027\027\024\f\021\017, \023\035\026\027\024\r\024\036 \017\035\017\ \220\022\f\021\030\036\027\027\024\036 \024\002\030\026\013\036\027\017\ \036, \f\021\026)Tj 0 Tw (-)Tj -0.018 Tw T* (\007\017\033 \024\023\031\b\024\035\017, \024\f\035\024\032\027\036\027\017\ \016 \024\023\031\b\024\035\017 \017\035\017 \002\036\030\036\n\036\027\027\ \024\f\021\017 )Tj 0 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\030\036\001\036\027\017\036 \023\026\006\017\036\027\021\026 [3,9].)Tj 0.012 Tc 0.814 Tw T* [(\221\024\020\035\026\f\027\024 \f\024\r\030\036\n\036\027\027\t\n \026\035\ \020\024\030\017\021\n\026\n, \r\024\n\024\032\027\024)12( )]TJ 0.259 Tw 0 -1.218 TD (\017)Tj /Span<>> BDC ( )Tj EMC [(\002\036\024\023\026\f\027\024 \023\030\024\r\036\007\036\027\017\036 \b\ \017\030\031\030\020\017\004\036\f\022\024\020\024 \035\036\004\036\027\017\ \016)12( )]TJ 0.037 Tw 0 -1.218 TD (\r)Tj /Span<>> BDC ( )Tj EMC [(\f\030\024\022\036 )0.5(\007\024)]TJ /Span<>> BDC ( )Tj EMC [(20 \027\036\007\036\035\034 )0.5(\002\036\030\036\n\036\027\027\024\f\021\017 [4,5,10]. \203\026)]TJ /Span<>> BDC ( )Tj EMC 20.728 0 Td (\002\024)Tj 0 Tc 0 Tw (-)Tj 0.012 Tc 0.351 Tw -20.728 -1.218 Td [(\035\036\036 \023\024\007\027\036\n \f\030\024\022\036 \002\036\030\036\ \n\036\027\027\024\f\021\017 \030\036\022\024\n\036\027\007\031\036\021\f\ \016)12( )]TJ 0.257 Tw T* (\024\021\035\024\032\017\021\034 \024\023\036\030\026\006\017\033, \004\021\ \024\002\t \024\002\036\f\023\036\004\017\021\034 \027\036\024\002\b\024\ \007\017)Tj 0 Tc 0 Tw (-)Tj 0.012 Tc 0.081 Tw T* [(\n\024\036 \f\024\030\036\r\026\027\017\036 \023\035\024\007\026. \025\030\ \024\n\036 \021\024\020\024, \030\036\022\024\n\036\027\007\024\r\026\027\ \024)12( )]TJ 0.048 Tw T* (\023\030\024\r\036\007\036\027\017\036 \024\023\036\030\026\006\017\017 \ \023\024)Tj /Span<>> BDC ( )Tj EMC [(\023\024\r\024\007\031 )0.5(\030\026\022\026 )0.5(\021\024\035\f\021\024\005 )0.5(\022\017\001)]TJ 0 Tc 0 Tw (-)Tj 0.012 Tc 0.156 Tw 0 -1.218 TD [(\022\017 \f\030\026\031 \023\024\f\035\036 \027\036\024\f\035\024\032\027\ \036\027\027\024\020\024 \022\036\f\026\030\036\r\026 \f\036\004\036\027\ \017\016)12( )]TJ -0.012 Tw 0 -1.218 TD ([6,7,11].)Tj 0 Tc 0.305 Tw 0 -1.218 TD (\200\024 \r\030\036\n\016 \035\026\023\026\030\024\f\022\024\023\017\004\ \036\f\022\024\005 \024\023\036\030\026\006\017\017 \023\026\006\017\036\ \027\021\022\036 )Tj 0.102 Tw T* (\f\035\036\007\031\036\021 \023\030\017\007\026\021\034 \027\026\022\035\ \024\027 \r\035\036\r\024, \004\021\024\002\t \023\030\036\007\024\021\r\ \030\026\021\017\021\034 )Tj 0.012 Tw T* (\f\007\026\r\035\036\027\017\036 \n\026\021\022\024\005 \027\017\032\027\ \036\005 \023\024\035\024\005 \r\036\027\t. \221\035\036\007\031\036\021\ \022\024\027\021)Tj 0 Tw (-)Tj 0.027 Tw T* (\030\024\035\017\030\024\r\026\021\034 \020\026\t \022\030\024\r\017 \n\ \026\021\036\030\017, \021\026\022 \022\026\022 \017\027\f\031\235\235\035\ \016\006\017\016 )Tj -0.044 Tw T* (\031\020\035\036\022\017\f\035\024\020\024 \020\026\026 \n\024\032\036\021\ \r\t\r\026\021\034 \020\017\023\036\030\022\026\023\027\017\033 \n\026\ \021\036\030\017, )Tj -0.03 Tw T* [(\004\021\024 \n\024\032\036\021 )0.5(\023\030\017\r\036\f\021\017 \022)]TJ /Span<>> BDC ( )Tj EMC 8.994 0 Td [(\020\017\023\036\030\022\026\023\027\017\017 )0.5(\023\035\024\007\026, \021\026\b\017\022\026\030\007\017\017 )]TJ -0.027 Tw -8.994 -1.218 Td (\017)Tj /Span<>> BDC ( )Tj EMC (\020\017\023\036\030\021\024\027\017\017 [8,12]. \210\021\007\036\035\034\ \027\024\036 \r\027\017\n\026\027\017\036 \f\035\036\007\031\036\021 \024\ \002)Tj 0 Tw (-)Tj 0.055 Tw T* (\030\026\021\017\021\034 \027\026)Tj /Span<>> BDC ( )Tj EMC (\006\036\035\036\f\024\024\002\030\026\027\024\f\021\034 \021\013\026\021\ \036\035\034\027\024\020\024 \017\f\f\035\036\007\024\r\026)Tj 0 Tw (-)Tj T* (\027\017\016 \023\035\026\006\036\027\021\t \027\026)Tj /Span<>> BDC ( )Tj EMC (\027\026\035\017\004\017\036 \n\036\021\026\f\021\026\024\r.)Tj 0.186 Tw T* (\203\026 \r\t\002\024\030 \n\036\021\024\007\026 \035\036\004\036\027\017\ \016 \017)Tj /Span<>> BDC ( )Tj EMC (\r\030\036\n\016 \036\020\024 \023\030\024\r\036\007\036\027\017\016 )Tj 0.076 Tw T* [(\024\022\026\t\r\026\033\021 )0.5(\r\035\017\016\027\017\036 )0.6(\n\024\030\026\035\034\027\t\036 )0.6(\f\024\024\002\030\026\032\036\027\017\016 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 20.033 0 Td (\031\f\021\026)Tj 0 Tw (-)Tj 0.283 Tw -20.033 -1.218 Td (\027\024\r\022\026 \f\026\n\024\005 \002\024\035\034\027\024\005 \r)Tj /Span<>> BDC ( )Tj EMC (\024\021\027\024\001\036\027\017\017 \002\036\030\036\n\036\027\027\024\f\ \021\017. )Tj 0.154 Tw T* (\215\030\017\027\017\n\026\016 \r\024 \r\027\017\n\026\027\017\036 \031\020\ \030\024\031 \030\017\f\022\026 \030\026\027\027\036\020\024 \n\036\021\ \026)Tj 0 Tw (-)Tj 0.249 Tw T* (\f\021\026\017\030\024\r\026\027\017\016, \027\036\024\002\b\024\007\017\ \n\024 \031\002\036\007\017\021\034 \032\036\027\013\017\027\031 \r)Tj /Span<>> BDC ( )Tj EMC (\006\036)Tj 0 Tw (-)Tj 0.222 Tw T* (\035\036\f\024\024\002\030\026\027\024\f\021\017 \027\026\004\026\021\034\ \035\036\004\036\027\017\036 \f)Tj /Span<>> BDC ( )Tj EMC (\n\024\n\036\027\021\026 \007\017\026\020\027\024)Tj 0 Tw (-)Tj 0.05 Tw T* (\f\021\017\030\024\r\026\027\017\016 \030\026\022\026, \026)Tj /Span<>> BDC ( )Tj EMC (\002\036\030\036\n\036\027\027\024\f\021\034 \r)Tj /Span<>> BDC ( )Tj EMC (I \017)Tj /Span<>> BDC ( )Tj EMC (II \021\030\017\n\036\f\021\030\026\b )Tj 0.026 Tw T* (\(\007\024 20 \027\036\007\036\035\034\) \035\031\004\001\036 \023\030\036\ \030\r\026\021\034. \213\f\035\017 \032\036\027\013\017\027\026 \r)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\021 )Tj 0.024 Tw T* [(\f\030\024\022 )0.5(\027\036 )0.5(\026\017\027\021\036\030\036\f\024\r\026\027\026 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 10.961 0 Td [(\f\024\b\030\026\027\036\027\017\017 )0.6(\002\036\030\036\n\036\027\027\024\f\021\017, )]TJ 0.095 Tw -10.961 -1.218 Td (\026)Tj /Span<>> BDC ( )Tj EMC (\024\023\031\b\024\035\034 \024\023\036\030\026\002\036\035\034\027\026,\ \021\024 \024\f\031\013\036\f\021\r\035\016\036\021\f\016 \030\036\036\ \022\006\017\016 )Tj -0.007 Tw T* [(\021\024\035\f\021\024\005 )0.5(\022\017\001\022\017 \f)]TJ /Span<>> BDC ( )Tj EMC [(\027\026\035\024\032\036\027\017\036\n )0.5(\026\027\026\f\021\024\n\024\026. )0.5(\215\024\f\035\036 20-\005 )]TJ 0.218 Tw T* [(\027\036\007\036\035\017 \002\036\030\036\n\036\027\027\024\f\021\017 )0.5(\027\026\017\002\024\035\036\036 \023\030\017\036\n\035\036\n \023\030\017\ \027\006\017\023 )]TJ 0.637 Tw T* [(\027\036\026\n\036\007\035\017\021\036\035\034\027\024\020\024 )0.6(\b\017\030\031\030\020\017\004\036\f\022\024\020\024 )0.6(\035\036\004\036\027\017\016 )0.5(\025\217\217 )]TJ 0.037 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC 0.706 0 Td [(\024\007\027\024\r\030\036\n\036\027\027\t\n )0.6(\030\024\007\024\030\026\030\036\001\036\027\017\036\n )0.6(\023\030\017)]TJ /Span<>> BDC ( )Tj EMC 16.587 0 Td [(\023\024\n\024\013\017 )0.6(\022\036)]TJ 0 Tw (-)Tj 0.052 Tw -17.294 -1.218 Td (\f\026\030\036\r\026 \f\036\004\036\027\017\016. \210\027\024 \023\024\022\ \026\026\027\024 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\027\026\035\017\004\017\017 \024\023\031\b\024\035\017, )Tj 0.197 Tw T* [(\235\017\022\f\017\030\024\r\026\027\027\024\005 )0.6(\r)]TJ /Span<>> BDC ( )Tj EMC 7.912 0 Td [(\023\024\035\024\f\021\017 )0.6(\021\026\026, )0.5(\f\031\032\017\r\026\033\013\036\005 )0.6(\030\024\007\024)]TJ 0 Tw (-)Tj 0.008 Tw -7.912 -1.218 Td (\r\024\005 \022\026\027\026\035, \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\017 \030\026\f\023\024\035\024\032\036\027\017\017 \024\023\031\ \b\024\035\017 \027\026)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\036\007\027\036\005 )Tj -0.027 Tw T* (\f\021\036\027\022\036 \023\030\016\n\024\005 \022\017\001\022\017. \200\ )Tj /Span<>> BDC ( )Tj EMC (\f\035\031\004\026\036 \r\024\r\035\036\004\036\027\017\016 \r)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\006\036\f\f )Tj 0.198 Tw T* (\n\026\021\022\017 \r\n\036\f\021\036 \f)Tj /Span<>> BDC ( )Tj EMC (\030\036\036\022\006\017\036\005 \017\035\017 \027\017\r\036\007\036\027\ \017\036\n \022\017\001\022\017 )Tj 0.45 Tw T* (\023\030\024\r\024\007\017\021\f\016 \021\024\021\026\035\034\027\026\016\ \026\002\007\024\n\017\027\026\035\034\027\026\016 \020\017\f\021\036\030\ \220\022\021\024)Tj 0 Tw (-)Tj 0.13 Tw T* (\n\017\016. \203\036\f\n\024\021\030\016 \027\026)Tj /Span<>> BDC ( )Tj EMC (\021\024, \004\021\024 \031)Tj /Span<>> BDC ( )Tj EMC (24% \002\024\035\034\027\t\b \025\217\217 \f\031\013\036)Tj 0 Tw (-)Tj -0.005 Tw T* [(\f\021\r\031\036\021 )0.5(\024\023\026\f\027\024\f\021\034 )0.6(\r\024\027\017\022\027\024\r\036\027\017\016 )0.6(\n\036\021\026\f\021\026\024\r )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 19.269 0 Td (\016\017\004\027\017)Tj 0 Tw (-)Tj -0.048 Tw -19.269 -1.218 Td (\022\026\b, \031)Tj /Span<>> BDC ( )Tj EMC 2.367 0 Td [(\024\023\036\030\026\002\036\035\034\027\t\b )0.5(\002\024\035\034\027\t\b )0.5(\r\024 \r\030\036\n\016 \r\n\036\001\026\021\036\035\034\f\021\r\026 )]TJ -0.057 Tw -2.367 -1.218 Td (\023\024)Tj /Span<>> BDC ( )Tj EMC (\031\007\026\035\036\027\017\033 \024\023\031\b\024\035\017 \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\017 \030\036\001\036\027\017\017 \r\024\023\030\024\f\026 \024)Tj /Span<>> BDC ( )Tj EMC (\f\024\b\030\026)Tj 0 Tw (-)Tj 0.156 Tw T* (\027\036\027\017\017 \002\036\030\036\n\036\027\027\024\f\021\017 \027\036\ \030\036\022\024\n\036\027\007\031\036\021\f\016 \r\t\023\024\035\027\036\ \027\017\036 )Tj 0.266 Tw T* (\f\026\035\034\023\017\027\020\024\024\235\024\030\220\022\021\024\n\017\ \017 \f)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\235\017\035\026\022\021\017\004\036\f\022\024\005 \006\036\035\ \034\033 )Tj 0.006 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC [(\f\r\016\017 )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC 3.955 0 Td [(\021\036\n, )0.5(\004\021\024 \031\007\026\035\036\027\017\036 )0.5(\016\017\004\027\017\022\024\r )0.5(\004\030\036\r\026\021\024 )0.5(\030\017\f\022\024\n )]TJ -0.04 Tw -3.955 -1.218 Td [(\f\023\024\027\021\026\027\027\024\020\024 )0.6(\026\002\024\030\021\026, )0.5(\024\f\024\002\036\027\027\024 )0.6(\r)]TJ /Span<>> BDC ( )Tj EMC 13.359 0 Td [(\021\036\004\036\027\017\036 )0.6(\023\036\030\r\t\b )0.5(3 )0.5(\n\036)]TJ 0 Tw (-)Tj -0.021 Tw -13.359 -1.218 Td (\f\016\006\036\r \002\036\030\036\n\036\027\027\024\f\021\017. \215\030\017\ )Tj /Span<>> BDC ( )Tj EMC (\023\024\007\024\030\036\027\017\017 \027\026)Tj /Span<>> BDC ( )Tj EMC (\027\026\035\017\004\017\036 \n\036)Tj 0 Tw (-)Tj -0.013 Tw T* (\021\026\f\021\026\024\r \023\024\022\026\026\027\024 \023\030\024\r\036\ \007\036\027\017\036 \022\035\017\027\024\r\017\007\027\024\005 \002\017\ \024\023\f\017\017 )Tj 0.317 Tw T* (\024\002\024\017\b \016\017\004\027\017\022\024\r. \207\024\035\034\027\t\ \n \f)Tj /Span<>> BDC ( )Tj EMC (\023\030\017\027\026\022\024\n \022\017\001\036\004\027\024\005 )Tj 0.153 Tw 23.244 64.543 Td (\027\036\023\030\024\b\024\007\017\n\024\f\021\017 \r)Tj /Span<>> BDC ( )Tj EMC (\030\036\031\035\034\021\026\021\036 \024\002\f\021\030\031\022\021\017\ \r\027\024\020\024 \023\024\030\026)Tj 0 Tw (-)Tj T* (\032\036\027\017\017 \022\017\001\022\017 \023\024\022\026\026\027\026 \ \022\024\035\024\f\021\024\n\017\016 [5,8,9,13].)Tj 0.094 Tw T* (\215\030\024\020\027\024 \007\035\016 \023\035\024\007\026 \023\030\017\ )Tj /Span<>> BDC ( )Tj EMC (\025\217\217 \r)Tj /Span<>> BDC ( )Tj EMC [(\027\026\004\017\021\036\035\034\027\024\005 )0.5(\f\021\036\023\036\027\017 )]TJ 0.127 Tw T* (\026\r\017\f\017\021 \024\021 \f\030\024\022\026 \002\036\030\036\n\036\ \027\027\024\f\021\017 \022\024 \r\030\036\n\036\027\017 \030\026\f\023\024\ )Tj 0 Tw (-)Tj 0.087 Tw T* (\027\026\r\026\027\017\016 \026\002\024\035\036\r\026\027\017\016 \017)Tj /Span<>> BDC ( )Tj EMC (\030\024\007\024\030\026\030\036\001\036\027\017\016, \017, \022\024\027\ \036\004\027\024 )Tj 0.093 Tw T* (\032\036, \024\021 \022\026\004\036\f\021\r\026 \031\b\024\007\026 \026\ )Tj /Span<>> BDC ( )Tj EMC (\030\036\002\036\027\022\024\n \023\024\f\035\036 \030\024\032\007\036\027\ \017\016. )Tj 0.428 Tw 0 -1.218 TD (\200\t\032\017\r\026\036\n\024\f\021\034 \027\024\r\024\030\024\032\007\036\ \027\027\t\b \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\030\024\007\024\030\026\030\036\001\036)Tj 0 Tw (-)Tj 0.115 Tw 0 -1.218 TD [(\027\017\017 )0.6(\r)]TJ /Span<>> BDC ( )Tj EMC 2.716 0 Td [(\f\030\024\022 )0.5(28 )0.5(\027\036\007\036\035\034 )0.6(\002\036\030\036\n\036\027\027\024\f\021\017 )0.6(\007\024\f\021\017\020\026\036\021 )0.5(87%. )]TJ 0.106 Tw -2.716 -1.218 Td [(\203\026\035\017\004\017\036 )0.6(\031)]TJ /Span<>> BDC ( )Tj EMC 4.644 0 Td [(\002\036\030\036\n\036\027\027\t\b )0.5(\027\017\022\024\007\017\235\235\036\030\036\027\006\017\030\024\r\026\027\ \027\024\020\024 )]TJ 0.204 Tw -4.644 -1.218 Td (\025\217\217 \r)Tj /Span<>> BDC ( )Tj EMC (\f\r\016\017 \f)Tj /Span<>> BDC ( )Tj EMC (\022\030\026\005\027\036 \027\036\002\035\026\020\024\023\030\017\016\021\ \027\t\n \023\030\024\020\027\024\024\n )Tj 0.086 Tw T* [(\016\r\035\016\036\021\f\016 \023\024\022\026\026\027\017\036\n )0.5(\007\035\016 \023\030\036\030\t\r\026\027\017\016 \002\036\030\036\n\036\ \027\027\024\f\021\017 )]TJ 0.065 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\035\033\002\024\n \f\030\024\022\036 \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\r\036\007\036\027\017\016 \027\036\026\n\036\007\035\017\021\ \036\035\034\027\024\020\024 \035\036)Tj 0 Tw (-)Tj 0 -1.218 TD (\004\036\027\017\016 [9,10,14].)Tj 0.526 Tw 0 -1.218 TD (\222\f\023\024\035\034\024\r\026\027\017\036 \b\017\n\017\024\021\036\030\ \026\023\036\r\021\017\004\036\f\022\017\b \023\030\036\023\026\030\026\021\ \024\r )Tj 0.053 Tw 0 -1.218 TD (\023\030\017)Tj /Span<>> BDC ( )Tj EMC (\025\217\217 \031)Tj /Span<>> BDC ( )Tj EMC (\002\036\030\036\n\036\027\027\t\b \024\f\021\026\036\021\f\016 \027\036\ \024\023\030\036\007\036\035\036\027\027\024\005 \024\002)Tj 0 Tw (-)Tj -0.047 Tw T* (\035\026\f\021\034\033, \r\t\t\r\026\033\013\036\005 \n\027\024\032\036\ \f\021\r\024 \023\030\024\002\035\036\n \f)Tj /Span<>> BDC ( )Tj EMC (\021\024\004\022\017 \030\036)Tj 0 Tw (-)Tj -0.07 Tw T* (\027\017\016 \220\021\017\022\017, \002\036\024\023\026\f\027\024\f\021\ \017 \017)Tj /Span<>> BDC ( )Tj EMC (\220\235\235\036\022\021\017\r\027\024\f\021\017. \003\007\036\f\034 \r\026\ \032)Tj 0 Tw (-)Tj -0.02 Tw T* [(\027\024 )0.6(\f\024\023\024\f\021\026\r\017\021\034 )0.6(\030\017\f\022\017 )0.6(\007\035\016 )0.5(\023\035\024\007\026 )0.6(\f)]TJ /Span<>> BDC ( )Tj EMC 14.064 0 Td [(\023\024\035\034\024\005 )0.6(\024\021 )0.6(\035\036\004\036\027\017\016 )]TJ 0.099 Tw -14.064 -1.218 Td [(\023\026\006\017\036\027\021\022\017. )0.5(\217\036\001\036\027\017\016 )0.5(\024)]TJ /Span<>> BDC ( )Tj EMC [(\021\036\030\026\023\017\017, \r\035\017\016\033\013\017\036 )0.5(\027\026)]TJ /Span<>> BDC ( )Tj EMC (\r\t\002\024\030 )Tj 0.067 Tw T* [(\021\026\022\021\017\022\017 \035\036\004\036\027\017\016, )0.5(\r\022\035\033\004\026\033\021 )0.5(\f\021\026\007\017\033 )0.5(\030\026\022\026, \017\f\b\024\007\t \007\035\016 )]TJ 0.094 Tw T* (\n\026\021\036\030\017, \r\030\036\007, \022\024\021\024\030\t\005 \n\024\ \032\036\021 \f\024\023\030\024\r\024\032\007\026\021\034 \026\007\036\030\ \032)Tj 0 Tw (-)Tj 0.192 Tw T* (\022\031 \035\036\004\036\027\017\016, \f\030\024\022\017 \035\036\004\036\ \027\017\016 \f)Tj /Span<>> BDC ( )Tj EMC (\031\004\036\021\024\n \002\036\030\036\n\036\027\027\024\f\021\017, )Tj 0.197 Tw T* (\023\024\021\036\027\006\017\026\035\034\027\t\036 \021\036\030\026\021\024\ \020\036\027\027\t\036 \220\235\235\036\022\021\t \017, \r)Tj /Span<>> BDC ( )Tj EMC (\b\031\007\001\036\n )Tj 0.164 Tw T* [(\f\035\031\004\026\036, \030\026\f\f\n\024\021\030\036\027\017\036 )0.5(\r\024\n\024\032\027\024\f\021\017 \023\030\036\030\t\r\026\027\017\016\ )0.5(\002\036)]TJ 0 Tw (-)Tj 0.013 Tw T* (\030\036\n\036\027\027\024\f\021\017. \203\036\017\r\036\f\021\027\t\036\ \235\026\022\021\024\030\t \f\031\013\036\f\021\r\031\033\021 \017-\026\ )Tj 0.116 Tw T* (\024\020\030\026\027\017\004\036\027\027\024\020\024 \r\024\007\036\005\ \f\021\r\017\016 \b\017\n\017\024\021\036\030\026\023\017\017 \r\024 \r\030\ \036\n\016 )Tj 0.097 Tw T* (\002\036\030\036\n\036\027\027\024\f\021\017, \027\036\024\002\b\024\007\ \017\n\024\f\021\017 \024\007\027\024\r\030\036\n\036\027\027\024\020\024\ \023\030\017)Tj 0 Tw (-)Tj 0.116 Tw T* (\n\036\027\036\027\017\016 \027\036\f\022\024\035\034\022\017\b \023\030\ \036\023\026\030\026\021\024\r, \030\026\035\017\004\027\t\005 \021\036\ \030\026\021\024)Tj 0 Tw (-)Tj 0.021 Tw T* (\020\036\027\027\t\005 \023\024\021\036\027\006\017\026\035, \007\030\031\ \020\017\036 \021\036\030\026\021\024\020\036\027\027\t\036 \r\024\007\036\ \005\f\021\r\017\016 )Tj -0.029 Tw T* [(\(\b\017\n\017\004\036\f\022\017\036, )0.6(\220\022\024\035\024\020\017\004\036\f\022\017\036, )0.5(\n\036\007\017\022\026\n\036\027\021\024\027\t\036\), )0.6(\007\026\027)]TJ 0 Tw (-)Tj 0.053 Tw T* (\027\t\036 \024\020\030\026\027\017\004\036\027\t \030\036\021\030\024\f\ \023\036\022\021\017\r\027\t\n\017 \f\035\031\004\026\016\n\017 \017)Tj /Span<>> BDC ( )Tj EMC (\235\026\030)Tj 0 Tw (-)Tj 0.482 Tw T* (\n\026\022\024\022\017\027\036\021\017\004\036\f\022\017\n\017 \017\n\036\ \027\036\027\017\016\n\017, \023\030\024\017\f\b\024\007\016\013\017\n\017\ )Tj 0 Tw T* (\r\024 \r\030\036\n\016 \002\036\030\036\n\036\027\027\024\f\021\017 [10\ ,15].)Tj 0.036 Tw T* (\205\026\030\n\026\022\024\022\017\027\036\021\017\004\036\f\022\017\036\ \017\n\036\027\036\027\017\016 \r\024 \r\030\036\n\016 \002\036\030\036\ \n\036\027)Tj 0 Tw (-)Tj 0.038 Tw T* (\027\024\f\021\017 \n\024\020\031\021 \r\035\017\016\021\034 \027\026)Tj /Span<>> BDC ( )Tj EMC (\n\036\021\026\002\024\035\017\n \017)Tj /Span<>> BDC ( )Tj EMC (\r\024\007\036\005\f\021\r\017\036 \b\017)Tj 0 Tw (-)Tj -0.059 Tw T* (\n\017\024\021\036\030\026\023\017\017 [11,12,16]. \200\024 \r\030\036\n\ \016 \002\036\030\036\n\036\027\027\024\f\021\017 \024\002\255\036\n )Tj -0.025 Tw T* (\030\026\f\023\030\036\007\036\035\036\027\017\016 \031\r\036\035\017\004\ \017\r\026\036\021\f\016, \f\r\016\t\r\026\027\017\036 \f)Tj /Span<>> BDC ( )Tj EMC (\002\036\035\022\026\n\017 )Tj 0.009 Tw T* (\f\027\017\032\026\036\021\f\016, \017\n\036\027\016\036\021\f\016 \023\ \036\004\036\027\024\004\027\t\005 \022\035\017\030\036\027\f \017)Tj /Span<>> BDC ( )Tj EMC (\031\r\036\035\017)Tj 0 Tw (-)Tj -0.044 Tw T* (\004\017\r\026\036\021\f\016 \023\024\004\036\004\027\026\016 \220\035\017\ \n\017\027\026\006\017\016 [12,13,17]. \214\036\022\026\030\f\021\r\026,\ )Tj 0.214 Tw T* (\022\024\021\024\030\t\036 \r\t\r\024\007\016\021\f\016 \023\024\004\022\ \026\n\017 \r)Tj /Span<>> BDC ( )Tj EMC (\027\036\017\n\036\027\036\027\027\024\n \r\017\007\036, )Tj 0.338 Tw T* (\n\024\020\031\021 \r\t\r\024\007\017\021\034\f\016 \002\t\f\021\030\036\ \036 \017-\026 \031\r\036\035\017\004\036\027\017\016 \022\035\017)Tj 0 Tw (-)Tj 0.131 Tw T* (\030\036\027\f\026 \022\030\036\026\021\017\027\017\027\026 \023\030\017\ \n\036\030\027\024 \027\026)Tj /Span<>> BDC ( )Tj EMC (50%, \023\030\017\004\036\n \031\r\036\035\017)Tj 0 Tw (-)Tj 0.1 Tw T* (\004\036\027\017\036 \027\026\002\035\033\007\026\036\021\f\016 \031\032\ \036 \027\026)Tj /Span<>> BDC ( )Tj EMC (9\22614 \027\036\007\036\035\036 \002\036\030\036\n\036\027\027\024)Tj 0 Tw (-)Tj 0.062 Tw T* (\f\021\017 \017)Tj /Span<>> BDC ( )Tj EMC (\007\024\f\021\017\020\026\036\021 \023\017\022\026, \024\f\024\002\036\027\ \027\024 \r\024 \r\021\024\030\024\n \021\030\017\n\036\f\021\030\036 )Tj -0.008 Tw T* ([13\22615,18]. \221\027\017\032\036\027\017\036 \026\035\034\002\031\n\017\ \027\026 \023\024\r\024\035\016\036\021 \023\024\035\031\004\017\021\034\ )Tj 0.482 Tw T* (\002\024\035\034\001\036 \027\036\f\r\016\026\027\027\024\020\024 \f\r\024\ \002\024\007\027\024\020\024 \035\036\022\026\030\f\021\r\026; \220\021\024\ )Tj 0.302 Tw T* (\024\f\024\002\036\027\027\024 \022\026\f\026\036\021\f\016 \023\030\024\ \021\017\r\024\024\023\031\b\024\035\036\r\t\b \023\030\036\023\026\030\026\ \021\024\r )Tj 0.009 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\r\t\f\024\022\024\005 \f\021\036\023\036\027\034\033 \f\r\016\t\r\026\027\ \017\016 \f)Tj /Span<>> BDC ( )Tj EMC (\002\036\035\022\026\n\017, \021\026\022\017\b \022\026\022 )Tj 0.03 Tw T* (\024\022\f\026\035\017\023\035\026\021\017\027, \022\024\021\024\030\t\005\ \f\r\016\t\r\026\036\021\f\016 \f)Tj /Span<>> BDC ( )Tj EMC (\002\036\035\022\026\n\017 \002\024\035\036\036 )Tj 0.138 Tw T* (\004\036\n \027\026)Tj /Span<>> BDC ( )Tj EMC (90% [17,19]. \222\n\036\027\036\027\017\016 \r)Tj /Span<>> BDC ( )Tj EMC (\023\036\004\036\027\017 \r\022\035\033\004\026\033\021 )Tj 0.122 Tw T* (\023\024\r\t\001\036\027\017\036 \026\022\021\017\r\027\024\f\021\017 \027\ \036\022\024\021\024\030\t\b \023\036\004\036\027\024\004\027\t\b \235\036\ \030)Tj 0 Tw (-)Tj 0.066 Tw T* [(\n\036\027\021\024\r, \021\026\022\017\b \022\026\022 UG)-12(T, CYP3A4, CYP2C9 \017)]TJ /Span<>> BDC ( )Tj EMC (CYP2A6, \004\021\024 )Tj 0.016 Tw T* (\n\024\032\036\021 \023\030\017\r\036\f\021\017 \022)Tj /Span<>> BDC ( )Tj EMC (\017\n\036\027\036\027\017\016\n \n\036\021\026\002\024\035\017\n\026 \ \035\036\022\026\030\f\021\r )Tj 0.459 Tw T* ([18,19]. \222\030\017\027\024\021\036\022\026\027 \017\n\036\036\021 \f\035\ \024\032\027\t\005 \n\036\021\026\002\024\035\017\n, )Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 0 Tw 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\033\030\031\030\213\b)-20.9(\035\231\213\233\t \021\032)50(\b)42(\032\231\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj /T1_2 1 Tf 25 0 0 25 505.4771 56.0378 Tm (103)Tj ET endstream endobj 1464 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.078 Tw 10 0 0 10 70.8661 724.8299 Tm (\f)Tj /Span<>> BDC ( )Tj EMC (\027\036\f\r\024\036\r\030\036\n\036\027\027\024\f\021\034\033 \007\017\026\ \020\027\024\f\021\017\022\017, \021\026\022 \022\026\022 \007\017\026\020\ \027\024 )Tj 0.104 Tw 0 -1.218 TD (\031)Tj /Span<>> BDC ( )Tj EMC (\027\026\004\017\021\036\035\034\027\024\020\024 \004\017\f\035\026 \002\ \036\030\036\n\036\027\027\t\b \031\f\021\026\027\026\r\035\017\r\026\036\ \021\f\016 )Tj 0 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\007\026\035\036\022\024 \026\001\036\007\001\036\005 \f\021\026\007\017\ \017 \026\002\024\035\036\r\026\027\017\016.)Tj 0.163 Tw T* [(\212\017\026\020\027\024 )0.5(\025\217\217 \f\021\026\r\016\021 \027\026)]TJ /Span<>> BDC ( )Tj EMC 10.128 0 Td [(\024\f\027\024\r\026\027\017\017 )0.5(\030\036\031\035\034\021\026\021\024\r \022\035\017)]TJ 0 Tw (-)Tj 0.042 Tw -10.128 -1.218 Td (\027\017\004\036\f\022\024\020\024, \030\036\027\021\020\036\027\024\035\ \024\020\017\004\036\f\022\024\020\024 \017)Tj /Span<>> BDC ( )Tj EMC (\220\027\007\024\f\022\024\023\017\004\036\f\022\024\020\024 )Tj -0.08 Tw T* (\n\036\021\024\007\024\r \017\f\f\035\036\007\024\r\026\027\017\016. \221\ \017\n\023\021\024\n\t \025\217\217 \027\036 \f\023\036\006\017\235\017\004\ \027\t )Tj 0.056 Tw 0 -1.218 TD (\017)Tj /Span<>> BDC ( )Tj EMC (\027\036\030\036\007\022\024 \f\024\r\023\026\007\026\033\021 \f)Tj /Span<>> BDC ( )Tj EMC (\024\002\t\004\027\t\n\017 \f\017\n\023\021\024\n\026\n\017 \002\036\030\ \036)Tj 0 Tw (-)Tj -0.001 Tw 0 -1.218 TD [(\n\036\027\027\024\f\021\017, )0.5(\021\026\022\017\n\017 )0.5(\022\026\022 \021\024\001\027\024\021\026 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC [(\030\r\024\021\026, )0.5(\026\023\024\030, \031\007 )0.5(\017\035\017 )]TJ 0.03 Tw T* (\020\036\n\024\030\030\024\005, \026\027\036\n\017\016 \017)Tj /Span<>> BDC ( )Tj EMC (\030\036\022\021\026\035\034\027\024\036 \022\030\024\r\024\021\036\004\036\ \027\017\036. \215\024\f\035\036 )Tj 0.124 Tw T* (\023\024\f\021\026\027\024\r\022\017 \007\017\026\020\027\024\026 \024\002\ \f\035\036\007\024\r\026\027\017\036 \002\036\030\036\n\036\027\027\t\b \ \023\026)Tj 0 Tw (-)Tj -0.008 Tw T* (\006\017\036\027\021\024\022 \f)Tj /Span<>> BDC ( )Tj EMC (\025\217\217 \026\027\026\035\024\020\017\004\027\024 \024\002\f\035\036\ \007\024\r\026\027\017\033 \027\036\002\036\030\036\n\036\027)Tj 0 Tw (-)Tj 0.171 Tw T* [(\027\t\b \023\026\006\017\036\027\021\024\022. \210\002\f\035\036\007\024\ \r\026\027\017\036 )0.5(\021\030\036\002\031\036\021 \f\035\036\007\031\033\013\036\020\024: )]TJ 0.246 Tw 0 -1.218 TD (\022\024\035\024\027\024\f\022\024\023\017\016 \007\035\016 \r\t\016\r\035\ \036\027\017\016 \f\017\027\b\030\024\027\027\t\b \023\024\030\026\032\036\ )Tj 0 Tw (-)Tj 0.086 Tw 0 -1.218 TD [(\027\017\005; )0.5(\r\027\031\021\030\017\023\030\024\f\r\036\021\027\024\036 )0.5(\211\003\222 )0.5(\007\035\016 )0.6(\023\024\007\021\r\036\030\032\007\036\027\017\016 )0.5(\f\021\026)]TJ 0 Tw (-)Tj 0.104 Tw 0 -1.218 TD (\007\017\017 \023\024\030\026\032\036\027\017\016 \023\030\016\n\024\005\ \022\017\001\022\017; \n\024\027\017\021\024\030\017\027\020 \031\030\024\ \r\027\036\005 )Tj -0.011 Tw T* (\022\026\030\006\017\027\024\220\n\002\030\017\024\027\026\035\034\027\024\ \020\024 \026\027\021\017\020\036\027\026 \r)Tj /Span<>> BDC ( )Tj EMC (\f\t\r\024\030\024\021\022\036 \022\030\024\r\017 )Tj -0.035 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\006\036\035\016\b \023\024\f\035\036\007\031\033\013\036\020\024 \027\026\ \002\035\033\007\036\027\017\016; \017)Tj /Span<>> BDC ( )Tj EMC (\211\003\222 \023\036\004\036\027\017 \007\035\016 )Tj 0.388 Tw T* [(\r\t\016\r\035\036\027\017\016 )0.6(\n\036\021\026\f\021\026\021\017\004\036\f\022\024\020\024 )0.5(\026\002\024\035\036\r\026\027\017\016 )0.6(\023\036\004\036\027\017. )]TJ 0.164 Tw T* (\204\026\020\027\017\021\027\024-\030\036\024\027\026\027\f\027\026\016\ \021\024\n\024\020\030\026\235\017\016 \016\r\035\016\036\021\f\016 \023\ \024\007\b\024)Tj 0 Tw (-)Tj 0.001 Tw T* [(\007\016\013\036\005 )0.6(\026\n\036\027\024\005 )0.5(\022\024\n\023\034\033\021\036\030\027\024\005 )0.6(\021\024\n\024\020\030\026\235\017\017 )0.6(\023\030\017)]TJ /Span<>> BDC ( )Tj EMC 19.788 0 Td (\024\023\030\036)Tj 0 Tw (-)Tj 0.255 Tw -19.788 -1.218 Td (\007\036\035\036\027\017\017 \f\021\026\007\017\017, \022\024\020\007\026\ \220\021\024 \027\036\024\002\b\024\007\017\n\024. \025\024\020\007\026\ \030\026\022 )Tj 0.156 Tw T* (\023\030\016\n\024\005 \022\017\001\022\017 \007\017\026\020\027\024\f\021\ \017\030\031\036\021\f\016 \027\026)Tj /Span<>> BDC ( )Tj EMC (\023\024\007\027\017\b \f\021\026\007\017\016\b )Tj 0.122 Tw T* (\002\036\030\036\n\036\027\027\024\f\021\017, \023\030\024\r\024\007\017\ \021\f\016 \021\013\026\021\036\035\034\027\026\016 \024\006\036\027\022\ \026 \035\024\022\026)Tj 0 Tw (-)Tj 0.014 Tw T* (\035\017\026\006\017\017 \024\023\031\b\024\035\017 \017)Tj /Span<>> BDC ( )Tj EMC (\f\021\026\007\017\017 \030\026\022\026, \004\021\024\002\t \031\002\036\ \007\017\021\034\f\016, \004\021\024 )Tj 0.062 Tw T* [(\024\023\031\b\024\035\034 )0.6(\027\036 )0.5(\002\031\007\036\021 )0.5(\023\030\036\023\016\021\f\021\r\024\r\026\021\034 )0.5(\027\024\030\n\026\035\034\027\t\n )0.5(\030\024\007\026\n )]TJ 0 Tw T* ([5,8].)Tj 0.11 Tw T* (\217\036\022\024\n\036\027\007\026\006\017\017 \202\n\036\030\017\022\026\ \027\f\022\024\020\024 \024\002\013\036\f\021\r\026 \032\036\035\031\007\ \024\004\027\024-)Tj 0.233 Tw T* [(\022\017\001\036\004\027\024\005 )0.6(\220\027\007\024\f\022\024\023\017\017 )0.5(\031\022\026\t\r\026\033\021, )0.6(\004\021\024 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 17.74 0 Td (\f\017\021\031\026\006\017\016\b, )Tj 0.258 Tw -17.74 -1.218 Td (\022\024\020\007\026 \027\036\024\002\b\024\007\017\n\024 \021\036\030\026\ \023\036\r\021\017\004\036\f\022\024\036 \r\n\036\001\026\021\036\035\034\ \f\021\r\024, )Tj 0.48 Tw T* [(\220\027\007\024\f\022\024\023\017\016 )0.6(\023\030\036\007\035\026\020\026\036\021 )0.5(\024\021\027\024\f\017\021\036\035\034\027\024 )0.6(\002\036\024\023\026\f\027\031\033 )]TJ 0.014 Tw T* [(\026\035\034\021\036\030\027\026\021\017\r\031 )0.6(\030\026\007\017\024\035\024\020\017\004\036\f\022\024\n\031 )0.6(\017\035\017 )0.5(\b\017\030\031\030\020\017\004\036\f\022\024\n\031 )]TJ 0.093 Tw T* (\r\n\036\001\026\021\036\035\034\f\021\r\031. \224\027\007\024\f\022\024\ \023\017\033 \r\024 \r\030\036\n\016 \002\036\030\036\n\036\027\027\024\f\ \021\017 )Tj 0.222 Tw T* (\f\035\036\007\031\036\021 \023\030\024\r\024\007\017\021\034 \021\024\035\ \034\022\024 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\027\026\035\017\004\017\017 \r\036\f\022\017\b \023\024)Tj 0 Tw (-)Tj 0.028 Tw T* (\022\026\026\027\017\005 \017)Tj /Span<>> BDC ( )Tj EMC (\023\024 \r\024\n\024\032\027\024\f\021\017 \024\021\022\035\026\007\t\r\ \026\021\034 \036\036 \027\026)Tj /Span<>> BDC ( )Tj EMC (\r\021\024\030\024\005 )Tj 0.162 Tw T* (\021\030\017\n\036\f\021\030. \223\030\036\n\036\030\027\026\016 \f\036\ \007\026\006\017\016 \n\026\021\036\030\017, \023\030\017\r\024\007\016\013\ \026\016 )Tj 0.003 Tw T* (\022)Tj /Span<>> BDC ( )Tj EMC [(\020\017\023\024\r\036\027\021\017\035\016\006\017\017 )0.5(\017\035\017 )0.5(\020\017\023\024\021\024\027\017\017, )0.5(\017\035\017 \023\024\035\024\032\036\027\017\036 )0.5(\n\026)]TJ 0 Tw (-)Tj 0.136 Tw T* (\021\036\030\017, \022\024\021\024\030\024\036 \n\024\032\036\021 \023\030\ \017\r\036\f\021\017 \022)Tj /Span<>> BDC ( )Tj EMC (\f\007\026\r\035\036\027\017\033 \027\017\032\027\036\005 )Tj 0.232 Tw T* (\023\024\035\024\005 \r\036\027\t \n\026\021\022\024\005, \023\024\021\036\ \027\006\017\026\035\034\027\024 \n\024\032\036\021 \023\030\017\r\036\f\ \021\017 )Tj 0.063 Tw T* (\022)Tj /Span<>> BDC ( )Tj EMC (\f\027\017\032\036\027\017\033 \n\026\021\024\004\027\024\020\024 \022\030\ \024\r\024\021\024\022\026 \017)Tj /Span<>> BDC ( )Tj EMC (\020\017\023\024\022\f\017\017 \023\035\024\007\026. )Tj 0.261 Tw T* (\212\030\031\020\017\036 \023\024\021\036\027\006\017\026\035\034\027\t\036\ \030\017\f\022\017 \007\035\016 \023\035\024\007\026 \r\022\035\033\004\ \026\033\021 )Tj 0.175 Tw T* (\021\036\030\026\021\024\020\036\027\036 \(\024\021 \f\036\007\026\021\017\ \r\027\t\b \023\030\036\023\026\030\026\021\024\r\) \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\036\032\007\036)Tj 0 Tw (-)Tj 0.039 Tw T* (\r\030\036\n\036\027\027\t\036 \030\024\007\t [4]. \204\036\021\024\007 \ \204\217\230 \031)Tj /Span<>> BDC ( )Tj EMC (\002\036\030\036\n\036\027\027\t\b \023\030\036\007)Tj 0 Tw (-)Tj 0.142 Tw T* [(\023\024\004\021\017\021\036\035\034\027\036\036 )0.5(\035\033\002\024\020\024 \007\030\031\020\024\020\024 \n\036\021\024\007\ \026 \017\f\f\035\036\007\024\r\026\027\017\016, )]TJ 0 Tw T* (\017\f\023\024\035\034\031\033\013\036\020\024 \017\024\027\017\017\030\ \031\033\013\036\036 \017\035\031\004\036\027\017\036 [5,6,9].)Tj 0.189 Tw T* [(\200 \017\f\f\035\036\007\024\r\026\027\017\017 V)30(er)-24(ha)-17(gen \(1974\) \r\t\016\r\035\036\027\026 \026\r\017\f\017)]TJ 0 Tw (-)Tj 0.249 Tw T* (\n\024\f\021\034 \n\036\032\007\031 \021\030\017\n\036\f\021\030\024\n \002\ \036\030\036\n\036\027\027\024\f\021\017, \r)Tj /Span<>> BDC ( )Tj EMC (\022\024\021\024\030\024\n )Tj 0.079 Tw T* (\002\t\035 \023\024\f\021\026\r\035\036\027 \007\017\026\020\027\024 \025\ \217\217 \017)Tj /Span<>> BDC ( )Tj EMC (\n\026\021\036\030\017\027\f\022\024\005 \f\n\036\030\021\027\024)Tj 0 Tw (-)Tj -0.018 Tw T* (\f\021\034\033. \210\002\027\026\030\031\032\036\027\024, \004\021\024 \023\ \030\017)Tj /Span<>> BDC ( )Tj EMC (\r\t\016\r\035\036\027\017\017 \024\023\031\b\024\035\017 \r)Tj /Span<>> BDC ( )Tj EMC (\023\036\030)Tj 0 Tw (-)Tj 0.219 Tw T* (\r\024\n \021\030\017\n\036\f\021\030\036 \n\026\021\036\030\017\027\f\022\ \026\016 \f\n\036\030\021\027\024\f\021\034 \r)Tj /Span<>> BDC ( )Tj EMC (\007\r\026 \030\026\026 )Tj -0.003 Tw T* (\027\017\032\036, \004\036\n \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\007\017\026\020\027\024\f\021\017\022\036 \030\026\022\026 \r\024 \r\021\ \024\030\024\n \021\030\017\n\036\f\021\030\036 )Tj 0 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\r)Tj /Span<>> BDC ( )Tj EMC (\004\036\021\t\030\036 \030\026\026 \027\017\032\036, \004\036\n \r)Tj /Span<>> BDC ( )Tj EMC (\021\030\036\021\034\036\n \021\030\017\n\036\f\021\030\036.)Tj 0.109 Tw T* (\215\035\026\027 \035\036\004\036\027\017\016 \025\217\217 \007\024\035\032\ \036\027 \031\004\017\021\t\r\026\021\034 \017\027\021\036\030\036\f\t \007\ \r\031\b )Tj 0 Tw T* (\004\036\035\024\r\036\022, \n\026\021\036\030\017 \017)Tj /Span<>> BDC ( )Tj EMC (\023\035\024\007\026, \027\036\024\002\b\024\007\017\n\024 \004\036\021\022\ \024 \023\024\027\017\n\026\021\034 )Tj 0.008 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\f\024\002\035\033\007\026\021\034 \026\022\f\017\024\n\031: \007\035\016\ \n\026\021\036\030\017 \027\036\024\002\b\024\007\017\n\024 \027\026\004\ \026\021\034 )Tj 0.033 Tw 23.244 64.543 Td (\035\036\004\036\027\017\036 \022\026\022 \n\024\032\027\024 \f\022\024\030\ \036\036 \023\024\f\035\036 \030\024\032\007\036\027\017\016, \f\024\024\ \021\r\036\021)Tj 0 Tw (-)Tj -0.007 Tw T* (\f\021\r\036\027\027\024, \007\035\016 \023\035\024\007\026 \024\021\f\030\ \024\004\022\026 \021\036\030\026\023\017\017 \007\024)Tj /Span<>> BDC ( )Tj EMC (\021\036\b \023\024\030, \023\024\022\026 )Tj 0 Tw T* (\024\027 \027\036 \f\021\026\027\036\021 \032\017\027\036\f\023\024\f\024\ \002\027\t\n.)Tj -0.007 Tw T* (\025\217\217, \022\026\022 \023\030\026\r\017\035\024, \016\r\035\016\036\ \021\f\016, \023\030\036\017\n\031\013\036\f\021\r\036\027\027\024, \b\017\ \030\031\030)Tj 0 Tw (-)Tj 0.174 Tw T* (\020\017\004\036\f\022\024\005 \023\026\021\024\035\024\020\017\036\005 \ \027\026)Tj /Span<>> BDC ( )Tj EMC (\n\024\n\036\027\021 \r\t\016\r\035\036\027\017\016 \026\002\024\035\036\ )Tj 0 Tw (-)Tj 0.219 Tw T* (\r\026\027\017\016, \024\f\024\002\036\027\027\024 \r)Tj /Span<>> BDC ( )Tj EMC (\031\f\035\024\r\017\016\b \021\016\032\036\035\024\020\024 \024\f\035\024\ \032\027\036\027\017\016, )Tj 0.176 Tw 0 -1.218 TD [(\027\036 )0.5(\024\f\021\026\r\035\016\033\013\036\020\024 )0.6(\r\030\036\n\036\027\017 )0.5(\007\035\016 )0.5(\026\035\034\021\036\030\027\026\021\017\r\027\024\020\024 )0.6(\035\036)]TJ 0 Tw (-)Tj 0.247 Tw 0 -1.218 TD [(\004\036\027\017\016 )0.5(\(\027\036\023\030\024\b\024\007\017\n\024\f\021\034, )0.5(\023\036\030\235\024\030\026\006\017\016, )0.5(\027\026\004\017\021\036\035\034\027\024\036 )]TJ 0 Tw T* (\022\030\024\r\024\021\036\004\036\027\017\036\).)Tj -0.025 Tw T* (\200\024\023\030\024\f\t, \022\026\f\026\033\013\017\036\f\016 \021\026\022\ \021\017\022\017 \r\036\007\036\027\017\016 \002\036\030\036\n\036\027\027\ \024\f\021\017 )Tj 0.096 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\r\t\002\024\030\026 \n\036\021\024\007\026 \035\036\004\036\027\017\016\ \035\024\022\026\004\036\f\021\r\036\027\027\024\005 \024\023\031\b\024\ \035\017, )Tj 0.08 Tw T* (\f\024\004\036\021\026\033\013\036\005\f\016 \f)Tj /Span<>> BDC ( )Tj EMC (\002\036\030\036\n\036\027\027\024\f\021\034\033, \004\030\036\r\t\004\026\ \005\027\024 \f\035\024\032)Tj 0 Tw (-)Tj 0 -1.218 TD (\027\t \017)Tj /Span<>> BDC ( )Tj EMC (\021\030\031\007\027\024\030\026\030\036\001\017\n\t.)Tj 0.004 Tw 0 -1.218 TD (\230\026\022, \r)Tj /Span<>> BDC ( )Tj EMC [(\017\f\f\035\036\007\024\r\026\027\017\017 P)30(ell)-30.9(ino G, e)-12(t al. [2] \002\t\035 \023\030\024\r\036\007\036\027 )]TJ 0.087 Tw 0 -1.218 TD (\f\017\f\021\036\n\026\021\017\004\036\f\022\017\005 \024\002\024\030 \035\ \017\021\036\030\026\021\031\030\t \f)Tj /Span<>> BDC ( )Tj EMC (\006\036\035\034\033 \024\023\030\036\007\036)Tj 0 Tw (-)Tj -0.026 Tw T* (\035\036\027\017\016 \235\024\030\n\t \023\030\024\016\r\035\036\027\017\ \016 \017)Tj /Span<>> BDC ( )Tj EMC (\026\002\024\035\036\r\026\036\n\024\f\021\017 \022\024\035\024\030\036\ \022)Tj 0 Tw (-)Tj 0.01 Tw T* (\021\026\035\034\027\t\n \030\026\022\024\n \r\024 \r\030\036\n\016 \002\ \036\030\036\n\036\027\027\024\f\021\017, \024\006\036\027\022\017 \017\f\ \b\024)Tj 0 Tw (-)Tj -0.019 Tw T* (\007\024\r \031)Tj /Span<>> BDC ( )Tj EMC (\n\026\021\036\030\017 \017)Tj /Span<>> BDC ( )Tj EMC (\023\035\024\007\026 \r)Tj /Span<>> BDC ( )Tj EMC (\026\r\017\f\017\n\024\f\021\017 \024\021 \020\036\f\021\026\006\017\024\ \027\027\024\020\024 )Tj 0.035 Tw T* [(\r\024\030\026\f\021\026, )0.5(\023\030\024\r\036\007\036\027\027\024\020\024 )0.6(\035\036\004\036\027\017\016, )0.6(\024\f\024\002\036\027\027\024\f\021\036\005 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 20.783 0 Td (\035\024)Tj 0 Tw (-)Tj 0.3 Tw -20.783 -1.218 Td [(\022\026\035\017\026\006\017\017 )0.6(\030\026\022\026 )0.5(\007\035\016 )0.5(\r\t\016\r\035\036\027\017\016 )0.5(\017\f\f\035\036\007\024\r\026\027\017\005, )0.6(\f\024)]TJ 0 Tw (-)Tj 0.073 Tw T* (\024\002\013\026\033\013\017\b \024)Tj /Span<>> BDC ( )Tj EMC (\025\217\217, \017)Tj /Span<>> BDC ( )Tj EMC (\024\002\255\036\007\017\027\036\027\027\t\005 \026\027\026\035\017 \023\ \030\036\007\f\021\026\r)Tj 0 Tw (-)Tj 0.129 Tw T* (\035\036\027\027\t\b \007\026\027\027\t\b. \200)Tj /Span<>> BDC ( )Tj EMC (\017\f\f\035\036\007\024\r\026\027\017\017 \023\030\024\026\027\026\035\017\ \017\030\024\r\026\027\t )Tj -0.03 Tw T* (119 \022\035\017\027\017\004\036\f\022\017\b \f\035\031\004\026\036\r. \200\ )Tj /Span<>> BDC ( )Tj EMC (\030\036\031\035\034\021\026\021\036 \023\030\024\r\036\007\036\027\027\ \024\020\024 )Tj -0.048 Tw T* (\026\027\026\035\017\026 \002\t\035\024 \r\t\016\r\035\036\027\024, \004\ \021\024 \031)Tj /Span<>> BDC ( )Tj EMC (12% \023\026\006\017\036\027\021\024\022 \025\217\217 \002\t\035 )Tj -0.027 Tw T* (\007\017\026\020\027\024\f\021\017\030\024\r\026\027 \r)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\r\024\n, 41%)Tj /Span<>> BDC ( )Tj EMC (\227 \r\024 \r\021\024\030\024\n \017)Tj /Span<>> BDC ( )Tj EMC (47%)Tj /Span<>> BDC ( )Tj EMC (\227 )Tj 0.335 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC 1.042 0 Td [(\021\030\036\021\034\036\n )0.6(\021\030\017\n\036\f\021\030\036 )0.5(\002\036\030\036\n\036\027\027\024\f\021\017. )0.6(\215\024)]TJ /Span<>> BDC ( )Tj EMC 16.935 0 Td (\035\024\022\026\035\017\026)Tj 0 Tw (-)Tj 0.082 Tw -17.976 -1.218 Td (\006\017\017 \004\026\013\036 \r\f\036\020\024)Tj /Span<>> BDC ( )Tj EMC (\227 \r)Tj /Span<>> BDC ( )Tj EMC (\021\024\035\f\021\024\005 \022\017\001\022\036 53,4%, \r)Tj /Span<>> BDC ( )Tj EMC (\023\030\016\n\024\005 )Tj 0.029 Tw T* (\022\017\001\022\036)Tj /Span<>> BDC ( )Tj EMC (\227 44%, \024\002\001\017\030\027\024\036 \030\026\f\023\030\024\f\021\030\ \026\027\036\027\017\036)Tj /Span<>> BDC ( )Tj EMC (\227 \r)Tj /Span<>> BDC ( )Tj EMC (2,6% )Tj -0.017 Tw T* (\f\035\031\004\026\036\r. \202\027\026\035\017 \022\035\017\027\017\004\ \036\f\022\017\b \f\017\n\023\021\024\n\024\r \023\024\022\026\026\035,\ \004\021\024 )Tj 0.08 Tw T* (\004\026\013\036 \r\f\036\020\024 \r\024\027\017\022\026\035\024 \022\030\ \024\r\024\021\036\004\036\027\017\036)Tj /Span<>> BDC ( )Tj EMC (\227 \031)Tj /Span<>> BDC ( )Tj EMC (47% \023\026\006\017)Tj 0 Tw (-)Tj 0.133 Tw T* (\036\027\021\024\r, \002\024\035\034 \r)Tj /Span<>> BDC ( )Tj EMC (\032\017\r\024\021\036)Tj /Span<>> BDC ( )Tj EMC (\227 \031)Tj /Span<>> BDC ( )Tj EMC (37,6%, \026\023\024\030)Tj /Span<>> BDC ( )Tj EMC (\227 \031)Tj /Span<>> BDC ( )Tj EMC (14,1%, )Tj 0.099 Tw T* (\027\036\023\030\024\b\024\007\017\n\024\f\021\034)Tj /Span<>> BDC ( )Tj EMC (\227 \031)Tj /Span<>> BDC ( )Tj EMC (9,4% \017)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\235\024\030\026\006\017\016)Tj /Span<>> BDC ( )Tj EMC (\227 \031)Tj /Span<>> BDC ( )Tj EMC (2,4%. )Tj 0.171 Tw T* (\222)Tj /Span<>> BDC ( )Tj EMC (119 \023\026\006\017\036\027\021\024\022 9,8% \023\024\035\031\004\026\035\ \017 \b\017\n\017\024\021\036\030\026\023\017\033 \r\024 )Tj 0.215 Tw T* (\r\030\036\n\016 \002\036\030\036\n\036\027\027\024\f\021\017. \203\017 \ \031)Tj /Span<>> BDC ( )Tj EMC (\024\007\027\024\020\024 \017)Tj /Span<>> BDC ( )Tj EMC (\017\b \027\024\r\024\030\024\032)Tj 0 Tw (-)Tj 0.005 Tw T* (\007\036\027\027\t\b \027\036 \030\026\r\017\035\026\f\034 \f\021\024\005\ \022\026\016 \017\027\r\026\035\017\007\027\024\f\021\034, \031)Tj /Span<>> BDC ( )Tj EMC (\024\007\027\024\020\024 )Tj -0.024 Tw T* (\030\026\r\017\035\f\016 \020\017\023\024\021\017\030\036\024 \017)Tj /Span<>> BDC ( )Tj EMC (72% \027\024\r\024\030\024\032\007\036\027\027\t\b \024\f\021\026\035\017\ \f\034 )Tj 0.092 Tw T* (\032\017\r\t. \200\026\020\017\027\026\035\034\027\t\036 \030\024\007\t \ \017\n\036\035\017 \n\036\f\021\024 \r)Tj /Span<>> BDC ( )Tj EMC (60% \f\035\031\004\026)Tj 0 Tw (-)Tj 0.211 Tw T* (\036\r. \215\036\030\036\007\027\016\016 \030\036\036\022\006\017\016 \r\ \t\023\024\035\027\036\027\026 \031)Tj /Span<>> BDC ( )Tj EMC (30% \002\024\035\034\027\t\b, )Tj 0.119 Tw T* (\002\030\033\001\027\024-\023\030\024\n\036\032\027\024\f\021\027\026\016\ \030\036\036\022\006\017\016 \023\030\016\n\024\005 \022\017\001\022\017\ )Tj /Span<>> BDC ( )Tj EMC (\227 )Tj -0.002 Tw T* (\031)Tj /Span<>> BDC ( )Tj EMC 0.675 0 Td [(14,9%. )0.6(\211)]TJ /Span<>> BDC ( )Tj EMC 3.695 0 Td [(\023\016\021\017 )0.6(\023\026\006\017\036\027\021\024\r )0.6(\002\t\035\026 )0.6(\r\t\023\024\035\027\036\027\026 )0.6(\035\017\002\024 )0.6(\f\017\027)]TJ 0 Tw (-)Tj 0.164 Tw -4.37 -1.218 Td (\b\030\024\027\027\026\016 \(60%\), \035\017\002\024 \n\036\021\026\b\030\ \024\027\027\026\016 \030\036\036\022\006\017\016 \023\036\004\036\027\017\ )Tj 0.069 Tw T* (\(40%\). \204\036\007\017\026\027\026 \r\t\032\017\r\026\036\n\024\f\021\ \017 \031)Tj /Span<>> BDC ( )Tj EMC (\220\021\017\b \023\026\006\017\036\027\021\024\r \f\024)Tj 0 Tw (-)Tj 0.039 Tw T* (\f\021\026\r\017\035\026 42 \(0\226120\) \n\036\f\016\006\036\r. \215\016\ \021\034\007\036\f\016\021 \023\016\021\034 \023\030\024\006\036\027)Tj 0 Tw (-)Tj 0.057 Tw T* (\021\024\r \023\026\006\017\036\027\021\024\r \002\t\035\017 \032\017\r\t\ \027\026)Tj /Span<>> BDC ( )Tj EMC (\n\024\n\036\027\021 \023\024\f\035\036\007\027\036\020\024 \027\026)Tj 0 Tw (-)Tj 0.014 Tw T* (\002\035\033\007\036\027\017\016. \204\036\007\017\026\027\026 \r\t\032\017\ \r\026\036\n\024\f\021\017 \n\026\021\036\030\017 \f\024\f\021\026\r\017\ \035\026 )Tj 0.162 Tw T* (36 \(0\226360\) \n\036\f\016\006\036\r. \207\024\035\034\027\t\036 \030\026\ \022\024\n \023\030\016\n\024\005 \022\017\001\022\017 )Tj 0.179 Tw T* (\017\n\036\035\017 \002\024\035\036\036 \007\035\017\021\036\035\034\027\ \031\033 \r\t\032\017\r\026\036\n\024\f\021\034 \023\024)Tj /Span<>> BDC ( )Tj EMC (\f\030\026\r\027\036)Tj 0 Tw (-)Tj T* (\027\017\033 \f)Tj /Span<>> BDC ( )Tj EMC (\030\026\022\024\n \021\024\035\f\021\024\005 \022\017\001\022\017 \(P)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,0072\) [2,10].)Tj 0.1 Tw T* (\200 \027\026\f\021\024\016\013\036\036 \r\030\036\n\016 \027\036 \f\031\ \013\036\f\021\r\031\036\021 \f\021\026\027\007\026\030\021\027\t\b \f\b\ \036\n )Tj 0.198 Tw T* (\030\024\007\024\030\026\030\036\001\036\027\017\016 \017)Tj /Span<>> BDC ( )Tj EMC (\f\023\036\006\017\026\035\034\027\024\005 \021\036\030\026\023\017\017 \ \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\f\021\024\035\034 )Tj 0.14 Tw T* [(\f\035\024\032\027\024\005 )0.5(\022\035\017\027\017\004\036\f\022\024\005 )0.6(\f\017\021\031\026\006\017\017, )0.6(\022\026\022\024\005 )0.5(\016\r\035\016\036\021\f\016 )0.6(\f\024)]TJ 0 Tw (-)Tj T* (\004\036\021\026\027\017\036 \025\217\217 \017)Tj /Span<>> BDC ( )Tj EMC (\002\036\030\036\n\036\027\027\024\f\021\017.)Tj 0.267 Tw T* (\214\036\004\036\027\017\036 \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\020\027\024 \r)Tj /Span<>> BDC ( )Tj EMC (\026\r\017\f\017\n\024\f\021\017 \024\021 \f\021\026\007\017\017 \030\026\ \022\026 )Tj 0.478 Tw T* (\027\036 \024\021\035\017\004\026\033\021\f\016 \024\021 \021\026\022\024\ \r\t\b \r)Tj /Span<>> BDC ( )Tj EMC (\024\002\013\036\005 \023\024\023\031\035\016\006\017\017. )Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0 Tw 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\033\030\031\030\213\b)-20.9(\035\231\213\233\t \021\032)50(\b)42(\032\231\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj -51.938 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 23, \023\0221)69(, 202)69(4)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 23, \023\0221)69(, 202)69(4)]TJ /T1_2 1 Tf 25 0 0 25 20.7653 56.0378 Tm (102)Tj ET endstream endobj 1463 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\037)31(\025\007\025\002\016\n)-10(\026)11(\013\007\216\001\020\203 \002\013\n \220\022\f\016\002\016\024\016\001\001\ \025\006)-10(\026\216)]TJ 47.216 0 Td [(Color)31(ectal cancer and pr)31(egnancy)]TJ ET 0 0 0 1 K 1 j 1 J [0 2.997]0 d /GS1 gs q 1 0 0 1 46.0167 743.0544 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 43.0197 743.0544 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q [0 2.997]0 d q 1 0 0 1 46.0167 705.8466 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 43.0197 705.8466 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q 0 j 0 J q 1 0 0 1 42.5197 651.7774 cm 0 0 m 453.543 0 l S Q BT 0 0 0 1 k /T1_1 1 Tf 0.037 Tc 0.224 Tw 8 0 0 8 42.5596 731.2159 Tm [(F)3.2(O)-4.6(R)8.7( C)-17.4(I)-15.6(T)45.4(A)37.5(T)-24.5(I)-1.3(ON:)]TJ /T1_2 1 Tf 0.023 Tc 0.233 Tw 6.668 0 Td [( C)-15.9(h)-15.1(e)-12.1(r)-35.9(n)-14.9(y)-28.9(s)-8.8(h)-10.9(o)-10.3(v)-28.4(a)]TJ /Span<>> BDC ( )Tj EMC [(A)-23(.L)-29.5(.)-23.5(, M)-8.7(a)-10.2(r)-30.8(k)-3.7(o)-10.3(v)-51.8(i)-5(c)-10.2(h)]TJ /Span<>> BDC ( )Tj EMC [(V)39.7(.)-23.9(A)-22.9(.)-23.5(, C)-15.8(h)-15.2(e)-12(r)-35.9(n)-14.9(y)-24.2(a)-11.2(k)-3.7(o)-10.3(v)]TJ /Span<>> BDC ( )Tj EMC [(A)-23(.)-23.9(A)-23(.)-23.5(, K)-20(r)-30.8(a)-26.6(s)-26.1(i)-7.1(l)-29.4(n)-14(i)-6.6(k)-3.7(o)-10.3(v)]TJ /Span<>> BDC ( )Tj EMC [(S)-9.6(.E)-5.5(.)-23.6(, S)-10.3(h)-6.9(u)-7.1(m)-16.6(e)-19.1(i)-6.5(k)-41.1(i)-3.2(n)-7.8(a)]TJ /Span<>> BDC ( )Tj EMC [(A)-23(.)12.4(O)11.4(.)-23.5(, T)43.3(r)-30.3(u)-21.9(s)-8.8(h)-7(u)-9.6(k)]TJ /Span<>> BDC ( )Tj EMC [(Y)51.3(.)-7.3(M)-7.1(.)-23.5(, D)-30.3(i)-7.1(l)]TJ /Span<>> BDC ( )Tj EMC [(O)11.4(.)-26.9(S)-9.6(.)-23.5(,)23( )]TJ 0.031 Tc 0.35 Tw -6.673 -1.2 Td [(A)-13.4(r)-56.2(i)-3(n)-7.6(a )0.5(E)-5.4(. C)-15.7(h)-14.9(e)-11.9(r)-35.7(n)-14.7(y)-28.7(s)-8.6(h)-10.7(o)-10.1(v)-28.2(a)-36.8(, A)-13.4(r)-30.6(k)-16.6(h)-13.8(i)-2.4(p)-22.1(o)-10.1(v)-28.2(a)]TJ /Span<>> BDC ( )Tj EMC [(Y)51.6(.)-9.6(I)-10.1(. C)-16.2(o)-15.4(l)-20.7(o)-11.6(r)-18.9(e)-18.9(c)-41.3(t)-36.6(a)-11.2(l c)-21.3(a)-7.4(n)-9.8(c)-9.5(e)-11.9(r a)-7.4(n)-14.3(d )0.5(p)-13.5(r)-18.9(e)-20.8(g)-8.6(n)-7.6(a)-7.4(n)-9.8(c)-42.2(y)18.3(. )]TJ /T1_3 1 Tf 0.037 Tc -0.037 Tw [(K)10.1(o)-3.9(lo)-3.9(p)-1.4(r)-0.7(ok)-23(t)-1.6(o)-3.9(lo)-7(g)-17.1(i)3(a)2(.)]TJ /T1_2 1 Tf 0.017 Tc 0.364 Tw 41.562 0 Td [( 2)-22.7(0)-17.6(2)-5(4)-3.6(;)-4(2)-24.1(3)-7.8(\()23.9(1)30.4(\))0.7(:)7.1(10)-37.2(0)-46.6(\226)37(10)-4.5(7)66.3(.)-14.1( \()-14.7(i)-17(n)-14.1( R)-20.3(u)-35.7(s)-36.1(s)-29.3(.)29.4(\))-3.4(.)17( )]TJ -0.032 Tc 0.032 Tw -41.562 -1.2 Td [(h)-72.2(t)-104.4(t)-84.4(p)-73.7(s)-62.9(:)-53.1(/)29.7(/)-18.6(d)-66.1(o)-67.5(i)-55.2(.)-52.3(o)-66.8(r)-71.7(g)-77.8(/)-43.7(1)-41(0)-48.5(.)-60.6(3)-47.1(3)-70.9(8)-53.7(7)-50.4(8)-55(/)-47.1(2)-63.9(0)-45.7(7)-56.9(3)-68.3(-)-13.8(7)-44.3(5)-54.6(5)-63.9(6)-81.7(-)-45.2(2)-63.9(0)-58.8(2)-46.2(4)-83.5(-)-45.3(2)-65.3(3)-68.3(-1)-28.1(-1)-41(0)-78.4(0)-88.4(-1)-40.9(0)-45.7(7)]TJ /T1_1 1 Tf 0.01 Tc 0.296 Tw 0.005 -2.617 Td [(\026\020\021\033\030)5( \020\036\017)5( \013\033\021\033\013\023\030\037\023:)]TJ /T1_3 1 Tf 0 Tc 0.301 Tw 11.133 0 Td ( \224\031\032\021\002\013\n\027 \201\023\031\013\t\026\021\030\032 \201\023\ \031\013\t\031\031\027\025\006, \217\026\205\006\021\n-\025\t\t\023\031\030\ \n\027\026\024\031\023\022\t\013\025\017 \025\021\t\024\025\024\205\024 \ \n\021\013\n\023\n\202\025\025, \220\n\003\t\013\025\017 \217\215\240\037\ \212\201\217, )Tj 0.023 Tw -11.138 -1.2 Td (\033\031\032.)Tj /Span<>> BDC ( )Tj EMC (\222\n\n\033\031\032\026\024\025\027\021\020\017, \030.)Tj /Span<>> BDC ( )Tj EMC (5,. \220\n\003\t\013, 634009, \212\n\t\t\025\002; \024\031\023.8 \(3822\)\ 283-003; e-mail: a.cherniackow@yandex.ru)Tj /T1_1 1 Tf 0.01 Tc 0.063 Tw 0.005 -1.2 Td [(ADDRESS)5( F)13(OR)5( C)19(ORRESPONDEN)23(CE:)]TJ /T1_3 1 Tf 0 Tc 0.068 Tw 14.14 0 Td [( Ale)-15(x)10(ander A. Cher)-14(n)11(yak)13(ov)63.1(, Scientif)-43(ic R)21(esearch Institute of Oncology)42(, T)53(omsk Scientif)-42.9(ic R)21(esearch Center of the )]TJ 0.023 Tw -14.145 -1.2 Td [(R)22(ussian Academ)11.1(y of Sciences, Cooperativ)13.1(e st., 5, T)53(omsk, 634009, R)22(ussia; tel. 8 \(3822\) 283-003; e-mail: a.cher)-14(niack)13.1(ow@yande)-14.9(x.ru)]TJ 0 Tw 0 -2.792 TD (\200\026\024\026 \033\n\t\024\205\033\023\031\021\025\002)Tj /Span<>> BDC ( )Tj EMC (\227 29.11.2023)Tj /Span<>> BDC ( )Tj EMC 19.488 0 Td (\n\t\023\031 \030\n\032\026\005\n\024\013\025)Tj /Span<>> BDC ( )Tj EMC (\227 18.12.2023)Tj /Span<>> BDC ( )Tj EMC 18.78 0 Td (\032\025\021\002\024\n \013)Tj /Span<>> BDC ( )Tj EMC (\033\205\005\023\025\013\026\203\025\025)Tj /Span<>> BDC ( )Tj EMC (\227 12.02.2024)Tj ( )Tj -38.268 -1.375 Td (Received)Tj /Span<>> BDC ( )Tj EMC (\227 29.11.2023)Tj /Span<>> BDC ( )Tj EMC 19.488 0 Td (Revised)Tj /Span<>> BDC ( )Tj EMC (\227 18.12.2023)Tj /Span<>> BDC ( )Tj EMC 18.78 0 Td (Accepted for publication)Tj /Span<>> BDC ( )Tj EMC (\227 12.02.2024)Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 42.5896 590.8719 Tm (\023\023\034\226\034\022\031\034)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf 0 Tc 0.2 Tw 10 0 0 10 42.5197 566.5159 Tm [(\025\024\035\024\030\036\022\021\026\035\034\027\t\005 )0.6(\030\026\022 )0.5(\(\025\217\217\))]TJ /Span<>> BDC ( )Tj EMC 11.911 0 Td [(\227 )0.5(\220\021\024 )0.5(\035\024\022\026\004\036\f\021\r\036\027\027\024\036 )]TJ 0.258 Tw -11.911 -1.218 Td (\027\024\r\024\024\002\030\026\024\r\026\027\017\036, \022\024\021\024\030\ \024\036 \r\024\027\017\022\026\036\021 \031)Tj /Span<>> BDC ( )Tj EMC (\035\033\007\036\005, \022\026\022 )Tj 0.03 Tw 0 -1.218 TD (\023\030\026\r\017\035\024, \r)Tj /Span<>> BDC ( )Tj EMC (\023\024\032\017\035\024\n \r\024\030\026\f\021\036, \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\n \f\030\036\007\027\017\005 \r\024)Tj 0 Tw (-)Tj 0.235 Tw T* (\030\026\f\021 \023\024\f\021\026\027\024\r\022\017 \007\017\026\020\027\ \024\026 \f\024\f\021\026\r\035\016\036\021 68 \035\036\021 [1,2]. )Tj 0.16 Tw T* [(\202\027\026\035\017 \007\026\027\027\t\b \035\017\021\036\030\026\021\031\ \030\t )0.5(\023\024\f\035\036\007\027\036\020\024 \007\036\f\016\021\017\035\036\021\ \017\016 )]TJ -0.021 Tw T* (\023\024\022\026\026\035 \f\031\013\036\f\021\r\036\027\027\024\036 \031\ \r\036\035\017\004\036\027\017\036 \004\017\f\035\026 \002\024\035\036\036\ \n\024\035\024)Tj 0 Tw (-)Tj 0.003 Tw T* (\007\t\b \023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\025\217\217, \023\030\017\004\036\n \031\f\021\026\027\024\r\035\036\027\ \024, \004\021\024 \r)Tj /Span<>> BDC ( )Tj EMC (5,4% )Tj 0.34 Tw T* (\024\027 \007\017\026\020\027\024\f\021\017\030\031\033\021\f\016 \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \n\024\035\024\032\036 45 \035\036\021\ . )Tj 0.203 Tw T* (\221\030\036\007\017 \002\024\035\034\027\t\b \025\217\217 \022\024\035\017\ \004\036\f\021\r\024 \032\036\027\013\017\027 \r)Tj /Span<>> BDC ( )Tj EMC (1,5 \030\026\026 )Tj 0 Tw T* (\023\030\036\r\t\001\026\036\021 \004\017\f\035\024 \n\031\032\004\017\027\ .)Tj -0.027 Tw T* (\025\024\035\024\030\036\022\021\026\035\034\027\t\005 \030\026\022 \026\ \027\017\n\026\036\021 \f\036\007\034\n\024\036 \n\036\f\021\024 \r)Tj /Span<>> BDC ( )Tj EMC (\f\021\030\031\022)Tj 0 Tw (-)Tj 0.029 Tw T* (\021\031\030\036 \024\027\022\024\035\024\020\017\004\036\f\022\024\005 \ \023\026\021\024\035\024\020\017\017, \007\017\026\020\027\024\f\021\017\ \030\031\036\n\024\005 \r\024 )Tj 0.185 Tw T* (\r\030\036\n\016 \002\036\030\036\n\036\027\027\024\f\021\017, \f)Tj /Span<>> BDC ( )Tj EMC (\030\026\f\004\036\021\027\024\005 \026\002\024\035\036\r\026\036\n\024\ \f\021\034\033 )Tj 0.27 Tw T* (1 \027\026)Tj /Span<>> BDC ( )Tj EMC (13 000 \002\036\030\036\n\036\027\027\024\f\021\036\005. \221\030\036\007\ \027\017\005 \r\024\030\026\f\021 \023\024)Tj 0 Tw (-)Tj 0.225 Tw T* (\f\021\026\027\024\r\022\017 \007\017\026\020\027\024\026, \023\024)Tj /Span<>> BDC ( )Tj EMC (\007\026\027\027\t\n \035\017\021\036\030\026\021\031\030\t, \f\024\f\021\ \026\r)Tj 0 Tw (-)Tj 0.265 Tw T* (\035\016\036\021 31)Tj /Span<>> BDC ( )Tj EMC 3.789 0 Td (\020\024\007. \003\026)Tj /Span<>> BDC ( )Tj EMC [(\023\024\f\035\036\007\027\017\036 \027\036\f\022\024\035\034\022\024 )0.5(\007\036\f\016\021\017\035\036\021\017\005 )]TJ 0.314 Tw -3.789 -1.218 Td [(\004\017\f\035\024 )0.5(\f\035\031\004\026\036\r )0.5(\030\026\022\026, )0.5(\007\017\026\020\027\024\f\021\017\030\024\r\026\027\027\t\b )0.6(\r\024 )0.5(\r\030\036\n\016 )]TJ 0.3 Tw T* (\002\036\030\036\n\036\027\027\024\f\021\017, \027\026\004\017\021\036\035\ \034\027\024 \031\r\036\035\017\004\017\035\024\f\034 [2,3]. \224\021\024\ )Tj 0.141 Tw T* (\f\r\016\026\027\024 \f)Tj /Span<>> BDC ( )Tj EMC (\021\036\n, \004\021\024 \032\036\027\013\017\027\t \024\021\022\035\026\ \007\t\r\026\033\021 \007\036\021\024\030\024\032)Tj 0 Tw (-)Tj 0.161 Tw T* (\007\036\027\017\036 \007\024)Tj /Span<>> BDC ( )Tj EMC (\021\030\036\021\034\036\020\024 \017)Tj /Span<>> BDC ( )Tj EMC (\004\036\021\r\036\030\021\024\020\024 \007\036\f\016\021\017\035\036\021\ \017\005 \032\017\027\017 )Tj 0.218 Tw T* ([4,3]. \211\004\017\021\t\r\026\016 \021\036\027\007\036\027\006\017\033\ \022)Tj /Span<>> BDC ( )Tj EMC (\026\007\036\030\032\022\036 \007\036\021\024\030\024\032\007\036)Tj 0 Tw (-)Tj 0.069 Tw T* (\027\017\016, \026\002\024\035\036\r\026\036\n\024\f\021\034 \030\036\007\ \022\017\n\017 \f\035\031\004\026\016\n\017 \030\026\022\026 \r\024 \r\030\ \036)Tj 0 Tw (-)Tj 0.203 Tw T* [(\n\016 \002\036\030\036\n\036\027\027\024\f\021\017, )0.5(\r\036\030\024\016\021\027\024, )0.5(\002\031\007\036\021 \030\026\f\021\017. )0.5(\224\021\024\021 )0.5(\030\024\f\021 )]TJ 0.132 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\f\024\004\036\021\026\027\017\017 \f)Tj /Span<>> BDC ( )Tj EMC (\026\007\036\030\032\022\024\005 \007\036\021\024\030\024\032\007\036\027\ \017\016 \031\r\036\035\017\004\017\r\026)Tj 0 Tw (-)Tj 0.161 Tw T* (\036\021 \r\036\030\024\016\021\027\024\f\021\034 \022\024\035\024\030\036\ \022\021\026\035\034\027\024\020\024 \030\026\022\026, \007\017\026\020\027\ \024\f\021\017\030\024)Tj 0 Tw (-)Tj 0.03 Tw T* (\r\026\027\027\024\020\024 \r\024 \r\030\036\n\016 \002\036\030\036\n\036\ \027\027\024\f\021\017 \017\035\017 \r)Tj /Span<>> BDC ( )Tj EMC (\023\024\f\035\036\030\024\007\024\r\024\n )Tj 0 Tw T* (\023\036\030\017\024\007\036.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 0.01 Tc 0.018 Tw 14 0 0 14 42.5896 213.3539 Tm [(\f\026\017\031\034\022\024\232)5( \031)5(\016)-18.3(\240\034)-31(\024)35(\037\226\232)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf 0 Tc 0.422 Tw 10 0 0 10 42.5197 188.9979 Tm [(\207\t\035\017 )0.5(\023\030\024\026\027\026\035\017\017\030\024\r\026\027\t )0.5(\035\017\021\036\030\026\021\031\030\027\t\036 )0.6(\017\f\021\024\004\027\017\022\017 )]TJ 0.027 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC [(\n\036\007\017\006\017\027\f\022\017\b \002\026 \007\026\027\027\t\b P)20(ubMed, MedL)-31.9(ine, S)-24(copus )]TJ 0.153 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (1998 \023\024)Tj /Span<>> BDC ( )Tj EMC (2023 \020\020. \217\026\f\f\n\026\021\030\017\r\026\035\017\f\034 \220\023\ \017\007\036\n\017\024\035\024\020\017)Tj 0 Tw (-)Tj 0.033 Tw T* [(\004\036\f\022\017\036 \026\f\023\036\022\021\t, \007\017\026\020\027\024\ \f\021\017\004\036\f\022\017\036 )0.5(\026\035\020\024\030\017\021\n\t, )0.5(\021\026\022\021\017\022\026 )]TJ -0.032 Tw T* (\r\036\007\036\027\017\016 \023\026\006\017\036\027\021\024\022, \023\030\ \024\020\027\024\f\021\017\004\036\f\022\017\036 \022\030\017\021\036\030\ \017\017, \026)Tj /Span<>> BDC ( )Tj EMC (\021\026\022)Tj 0 Tw (-)Tj -0.03 Tw T* [(\032\036 \030\036\031\035\034\021\026\021\t )0.5(\023\024\f\035\036 \023\030\024\r\036\007\036\027\027\024\020\024 )0.5(\035\036\004\036\027\017\016. )0.5(\200)]TJ /Span<>> BDC ( )Tj EMC (\f\021\026\021\034\033 )Tj 0.125 Tw T* [(\r\022\035\033\004\036\027\t )0.5(2 \022\035\017\027\017\004\036\f\022\017\b )0.5(\023\030\017\n\036\030\026 \023\026\006\017\036\027\021\024\022 )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC (\025\217\217, )Tj -0.01 Tw T* (\026\f\f\024\006\017\017\030\024\r\026\027\027\t\n \f)Tj /Span<>> BDC ( )Tj EMC (\002\036\030\036\n\036\027\027\024\f\021\034\033, \022\024\021\024\030\t\ \036 \023\024\035\031\004\026)Tj 0 Tw (-)Tj 0.021 Tw T* [(\035\017 )0.5(\035\036\004\036\027\017\036 )0.6(\027\026)]TJ /Span<>> BDC ( )Tj EMC 6.102 0 Td [(\002\026\036 )0.5(\203\222\222 )0.5(\024\027\022\024\035\024\020\017\017 )0.5(\235\017\035\017\026\035 )0.5(\230\024\n\f\022\024\020\024 )]TJ 0 Tw -6.102 -1.218 Td (\203\222\204\037 \217\202\203.)Tj 0.149 Tw 23.244 51.148 Td [(\202\027\026\035\017 )0.5(\035\017\021\036\030\026\021\031\030\t )0.5(\023\024\022\026\026\035, \004\021\024 \024\002\013\017\005 )0.5(\031\030\024\r\036\027\034 \026)]TJ 0 Tw (-)Tj 0.187 Tw T* (\002\024\035\036\r\026\036\n\024\f\021\017 \025\217\217 \f)Tj /Span<>> BDC ( )Tj EMC (\023\024\023\030\026\r\022\024\005 \027\026)Tj /Span<>> BDC ( )Tj EMC (\r\024\030\026\f\021 \f\027\017\017\035)Tj 0 Tw (-)Tj 0.081 Tw 0 -1.218 TD [(\f\016, )0.5(\024\007\027\026\022\024 )0.5(\026\002\024\035\036\r\026\036\n\024\f\021\034 )0.6(\031\r\036\035\017\004\017\035\026\f\034 )0.6(\031)]TJ /Span<>> BDC ( )Tj EMC 17.788 0 Td (\023\026\006\017\036\027\021\024\r )Tj 0.342 Tw -17.788 -1.218 Td (\r)Tj /Span<>> BDC ( )Tj EMC (\r\024\030\026\f\021\036 20\22649)Tj /Span<>> BDC ( )Tj EMC (\035\036\021, \f)Tj /Span<>> BDC ( )Tj EMC (\036\032\036\020\024\007\027\t\n \031\r\036\035\017\004\036\027\017\036\n\ )Tj 0.147 Tw T* [(\023\030\017\n\036\030\027\024 )0.5(\027\026)]TJ /Span<>> BDC ( )Tj EMC 5.805 0 Td [(2% )0.5(\031)]TJ /Span<>> BDC ( )Tj EMC [(\023\026\006\017\036\027\021\024\r )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 8.018 0 Td [(\r\024\030\026\f\021\036 )0.5(20\22634)]TJ /Span<>> BDC ( )Tj EMC (\035\036\021 )Tj 0.241 Tw -13.823 -1.218 Td ([1,6]. \215\030\024\020\027\024\017\030\031\036\021\f\016, \004\021\024\ \r)Tj /Span<>> BDC ( )Tj EMC (2030 \020\024\007\031 \026\002\024\035\036\r\026\036)Tj 0 Tw (-)Tj -0.031 Tw 0 -1.218 TD (\n\024\f\021\034 \030\026\022\024\n \021\024\035\f\021\024\005 \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\016\n\024\005 \022\017\001\022\017 \031)Tj /Span<>> BDC ( )Tj EMC (\035\017\006 \r)Tj /Span<>> BDC ( )Tj EMC (\r\024\030\026\f\021\036 )Tj -0.028 Tw 0 -1.218 TD (20\22634)Tj /Span<>> BDC ( )Tj EMC (\035\036\021 \031\r\036\035\017\004\017\021\f\016 \027\026)Tj /Span<>> BDC ( )Tj EMC (90% \017)Tj /Span<>> BDC ( )Tj EMC (124,2%, \f\024\024\021\r\036\021\f\021\r\036\027)Tj 0 Tw (-)Tj 0.034 Tw 0 -1.218 TD (\027\024. \210\032\017\007\026\036\021\f\016, \004\021\024 \031)Tj /Span<>> BDC ( )Tj EMC (\035\033\007\036\005 \r)Tj /Span<>> BDC ( )Tj EMC (\r\024\030\026\f\021\036 35\22649)Tj /Span<>> BDC ( )Tj EMC (\035\036\021 \220\021\017 )Tj 0.114 Tw 0 -1.218 TD [(\023\024\022\026\026\021\036\035\017 )0.6(\r\024\030\026\f\021\031\021 )0.5(\027\026)]TJ /Span<>> BDC ( )Tj EMC 10.676 0 Td (27,7%)Tj /Span<>> BDC ( )Tj EMC 2.79 0 Td [(\227 )0.5(\023\030\017)]TJ /Span<>> BDC ( )Tj EMC 3.214 0 Td [(\030\026\022\036 )0.5(\021\024\035\f\021\024\005 )]TJ 0 Tw -16.681 -1.218 Td (\022\017\001\022\017 \017)Tj /Span<>> BDC ( )Tj EMC (\027\026 46%)Tj /Span<>> BDC ( )Tj EMC (\227 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\030\026\022\036 \023\030\016\n\024\005 \022\017\001\022\017 [1,7].)Tj 0.157 Tw 0 -1.218 TD (\212\017\026\020\027\024\f\021\017\022\026 \030\026\022\026 \r\024 \r\030\ \036\n\016 \002\036\030\036\n\036\027\027\024\f\021\017 \f\r\016\026\027\ \027\026 )Tj 0.009 Tw 0 -1.218 TD (\f)Tj /Span<>> BDC ( )Tj EMC (\021\016\032\036\035\t\n\017 \220\n\024\006\017\024\027\026\035\034\027\t\ \n\017 \017)Tj /Span<>> BDC ( )Tj EMC (\235\017\017\004\036\f\022\017\n\017 \027\026\020\030\031)Tj 0 Tw (-)Tj 0.036 Tw 0 -1.218 TD (\022\026\n\017 \007\035\016 \002\036\030\036\n\036\027\027\024\005 \032\036\ \027\013\017\027\t \017)Tj /Span<>> BDC ( )Tj EMC (\036\036 \f\036\n\034\017. \217\036\001\036\027\017\036 )Tj 0.001 Tw 0 -1.218 TD (\024)Tj /Span<>> BDC ( )Tj EMC 0.733 0 Td [(\023\030\036\030\t\r\026\027\017\017 )0.6(\002\036\030\036\n\036\027\027\024\f\021\017 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 12.083 0 Td [(\022\026\004\036\f\021\r\036 )0.6(\021\036\030\026\023\036\r\021\017\004\036)]TJ 0 Tw (-)Tj 0.081 Tw -12.817 -1.218 Td (\f\022\024\020\024 \r\t\002\024\030\026 \n\024\032\036\021 \036\013\036 \ \002\024\035\034\001\036 \031\r\036\035\017\004\017\021\034 \220\021\024\ \002\030\036)Tj 0 Tw (-)Tj 0.094 Tw 0 -1.218 TD (\n\016. \217\026\027\027\016\016 \007\017\026\020\027\024\f\021\017\022\026\ \017)Tj /Span<>> BDC ( )Tj EMC (\035\036\004\036\027\017\036 \r\026\032\027\t \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\022\024\035\024)Tj 0 Tw (-)Tj 0 -1.218 TD (\030\036\022\021\026\035\034\027\024\n \030\026\022\036 \r\024 \r\030\036\ \n\016 \002\036\030\036\n\036\027\027\024\f\021\017.)Tj 0.306 Tw 0 -1.218 TD [(\221\r\024\036\r\030\036\n\036\027\027\024 )0.6(\023\024\f\021\026\r\035\036\027\027\t\005 )0.5(\007\017\026\020\027\024 )0.6(\025\217\217, )0.5(\021\024 )0.5(\036\f\021\034 )]TJ 1.218 Tw 0 -1.218 TD (\r\t\016\r\035\036\027\017\036 \035\024\022\026\004\036\f\021\r\036\027\ \027\024\020\024 \027\024\r\024\024\002\030\026\024\r\026\027\017\016 )Tj 0.152 Tw 0 -1.218 TD (\027\026)Tj /Span<>> BDC ( )Tj EMC 1.358 0 Td [(\030\026\027\027\017\b )0.5(\f\030\024\022\026\b )0.6(\002\036\030\036\n\036\027\027\024\f\021\017, )0.5(\023\024\r\024\035\016\036\021 )0.6(\007\024\f\021\017\004\034 )]TJ 0.13 Tw -1.358 -1.218 Td (5-\035\036\021\027\036\005 \r\t\032\017\r\026\036\n\024\f\021\017 \r)Tj /Span<>> BDC ( )Tj EMC (70% \f\035\031\004\026\036\r, \004\026\f\021\024\021\026 \r\t)Tj 0 Tw (-)Tj 0.248 Tw 0 -1.218 TD (\016\r\035\036\027\017\016 \025\217\217 \r)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\r\024\n \021\030\017\n\036\f\021\030\036 \f\024\f\021\026\r\ \035\016\036\021 27%. )Tj 0.003 Tw 0 -1.218 TD (\203\024, \023\024)Tj /Span<>> BDC ( )Tj EMC (\007\026\027\027\t\n \f\021\026\021\017\f\021\017\022\017, \004\026\013\036\ \025\217\217 \007\017\026\020\027\024\f\021\017\030\031\036\021\f\016 )Tj -0.033 Tw 0 -1.218 TD (\r)Tj /Span<>> BDC ( )Tj EMC (\007\026\035\036\022\024 \026\001\036\007\001\036\005 \f\021\026\007\017\ \017 \017, \022\026\022 \023\030\026\r\017\035\024, \r\024 2\2263)Tj /Span<>> BDC ( )Tj EMC (\021\030\017)Tj 0 Tw (-)Tj 0.014 Tw 0 -1.218 TD (\n\036\f\021\030\026\b \002\036\030\036\n\036\027\027\024\f\021\017. \221\ )Tj /Span<>> BDC ( )Tj EMC (\024\007\027\024\005 \f\021\024\030\024\027\t, \220\021\024 \f\r\016\026\ \027\024 )Tj 0.019 Tw 0 -1.218 TD (\f)Tj /Span<>> BDC ( )Tj EMC (\030\036\007\022\024\f\021\034\033 \f\024\004\036\021\026\027\017\016 \007\ \026\027\027\024\005 \023\026\021\024\035\024\020\017\017 \017)Tj /Span<>> BDC ( )Tj EMC (\002\036\030\036\n\036\027)Tj 0 Tw (-)Tj 0.192 Tw 0 -1.218 TD [(\027\024\f\021\017, )0.5(\026)]TJ /Span<>> BDC ( )Tj EMC 3.843 0 Td [(\f )0.5(\007\030\031\020\024\005)]TJ /Span<>> BDC ( )Tj EMC 4.116 0 Td [(\227 )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC 2.286 0 Td [(\027\036\007\024\f\021\026\021\024\004\027\t\n )0.6(\017\027\235\024\030\n\017\030\024)]TJ 0 Tw (-)Tj 0.338 Tw -10.245 -1.218 Td (\r\026\027\017\036\n \026\022\031\001\036\030\024\r-\020\017\027\036\022\ \024\035\024\020\024\r \024)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\024\005 \023\026\021\024\035\024\020\017\017. )Tj -0.021 Tw 0 -1.218 TD (\203\036\002\035\026\020\024\023\030\017\016\021\027\024\036 \r\035\017\016\ \027\017\036 \002\036\030\036\n\036\027\027\024\f\021\017 \027\026)Tj /Span<>> BDC ( )Tj EMC (\022\035\017\027\017\004\036)Tj 0 Tw (-)Tj -0.018 Tw 0 -1.218 TD [(\f\022\024\036 )0.5(\021\036\004\036\027\017\036 )0.5(\025\217\217 )0.5(\023\024\007\021\r\036\030\032\007\026\036\021 )0.5(\n\027\036\027\017\036 )0.6(\022\035\017\027\017\006\017\f\021\024\r, )]TJ 0.202 Tw 0 -1.218 TD (\f\004\017\021\026\033\013\017\b, \004\021\024 \007\035\017\021\036\035\034\ \027\026\016 \r\t\032\017\007\026\021\036\035\034\027\026\016 \021\026\022\ \021\017\022\026 )Tj 0.172 Tw 0 -1.218 TD (\031)Tj /Span<>> BDC ( )Tj EMC 0.85 0 Td [(\024\023\036\030\026\002\036\035\034\027\t\b )0.6(\002\036\030\036\n\036\027\027\t\b )0.5(\023\030\017)]TJ /Span<>> BDC ( )Tj EMC 13.688 0 Td [(\220\021\024\005 )0.5(\035\024\022\026\035\017\026\006\017\017 )]TJ 0.217 Tw -14.538 -1.218 Td (\024\023\031\b\024\035\017 \027\036\007\024\023\031\f\021\017\n\026, \024\ \f\024\002\036\027\027\024 \r)Tj /Span<>> BDC ( )Tj EMC (\f\035\031\004\026\016\b, \007\017\026\020\027\024)Tj 0 Tw (-)Tj 0 -1.218 TD (\f\021\017\030\031\036\n\t\b \r)Tj /Span<>> BDC ( )Tj EMC (I \017)Tj /Span<>> BDC ( )Tj EMC (II \021\030\017\n\036\f\021\030\026\b.)Tj 0.157 Tw 0 -1.218 TD (\221\035\024\032\027\024\f\021\034 \007\017\026\020\027\024\f\021\017\022\ \017 \025\217\217 \026\022\035\033\004\026\036\021\f\016 \r)Tj /Span<>> BDC ( )Tj EMC (\021\024\n, \004\021\024 )Tj 0.021 Tw 0 -1.218 TD (\024\f\027\024\r\027\026\016 \004\026\f\021\034 \022\035\017\027\017\004\ \036\f\022\017\b \f\017\n\023\021\024\n\024\r \f\b\024\032\026 \f)Tj /Span<>> BDC ( )Tj EMC (\023\030\024)Tj 0 Tw (-)Tj 0.326 Tw 0 -1.218 TD (\016\r\035\036\027\017\036\n \021\024\022\f\017\022\024\026 \002\036\030\ \036\n\036\027\027\t\b. \223\026\013\036 \r\f\036\020\024 \030\026\022 )Tj 0.381 Tw 0 -1.218 TD (\007\017\026\020\027\024\f\021\017\030\031\036\021\f\016 \r)Tj /Span<>> BDC ( )Tj EMC (\021\030\036\021\034\036\n \021\030\017\n\036\f\021\030\036 \002\036\030\ \036\n\036\027\027\024)Tj 0 Tw (-)Tj 0.06 Tw 0 -1.218 TD (\f\021\017 \(\002\024\035\036\036 \004\036\n \r)Tj /Span<>> BDC ( )Tj EMC (50%\) \017)Tj /Span<>> BDC ( )Tj EMC (\r \021\036\004\036\027\017\036 \020\024\007\026 \023\024\f\035\036 \030\ \024\007\024\r )Tj 0 Tw 0 -1.218 TD (\(29%\) [4,7].)Tj 0.316 Tw 0 -1.218 TD (\200 \006\036\035\024\n \023\030\024\020\027\024 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\022\024\035\024\030\036\022\021\026\035\034\027\024\n \030\026\022\036 \ \031)Tj /Span<>> BDC ( )Tj EMC (\002\036)Tj 0 Tw (-)Tj 0.514 Tw 0 -1.218 TD [(\030\036\n\036\027\027\t\b \027\036\002\035\026\020\024\023\030\017\016\021\ \027\t\005, )0.5(\004\021\024 \002\t\r\026\036\021 \f\r\016\026\027\024 )]TJ 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 0 Tw 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\033\030\031\030\213\b)-20.9(\035\231\213\233\t \021\032)50(\b)42(\032\231\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj /T1_5 1 Tf 25 0 0 25 504.6522 56.0378 Tm (101)Tj ET endstream endobj 29 0 obj <> endobj 30 0 obj <> endobj 31 0 obj <> endobj 32 0 obj <> endobj 33 0 obj <> endobj 1488 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1489 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1490 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1491 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1492 0 obj <>/ExtGState<>/Font<>/ProcSet[/PDF/Text]/Properties<>/Shading<>/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1499 0 obj [1502 0 R] endobj 1500 0 obj <>stream q /GS0 gs /Fm0 Do Q 0 0 0 1 K 1 j 1 J [0 2.997]0 d /GS1 gs q 1 0 0 1 74.3631 358.6545 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 71.3661 358.6545 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q [0 2.997]0 d q 1 0 0 1 74.3631 321.4467 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 71.3661 321.4467 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q BT 0 0 0 1 k /T1_0 1 Tf 10 0 0 10 70.8661 724.8299 Tm (https://doi.org/10.33878/2073-7556-2024-23-1-100-107)Tj /T1_1 1 Tf 0 -2.436 TD [(\240)60(\255\037:6)113(1)112(6.3)58(4\022)-23.2(+\022)-23.3(6)113(1)112(6.35]-006.6:6)113(1)112(8.2)]TJ 1 0.68 0 0.12 k /GS0 gs 0.023 Tw 19 0 0 19 150.7995 670.97 Tm [(\037)31(\025\007\025\002\016\n)-10(\026)11(\013\007\216\001\020\203 \002\013\n \220\022)-23.3(\f\016\002\016\024\016\001\001\025\006)-10(\026\216)]TJ 0 0 0 1 k /GS1 gs 14 0 0 14 70.8661 646.4661 Tm [(\003\016\002\001\020\025\r\013\022)-23.2(\b)-31(.\035.\271, \005\013\002\n)10(\025\r\220\017\022)-23.2(\004.\b)-31(.\271, \003\016\002\001\205\n)10.1(\025\r\022)-23.3(\b)-31(.\b)-31(.\271, \037)20(\002\013\006\220\007\216\001\220\n)10(\025\r\022)-23.3(\021.\235.\262, )]TJ 0 -1.143 TD [(\206\215\024\016\203\n\220\001\013\022)-23.2(\b)-31(.\b)-31(.\262, \032)30(\002\215\224\215\n\022)-23.2(\200.\005.\271, \255\220\007\216\022)-23.2(\036.\021.\271, \003\016\002\001\020\025\r\013\022)-23.2(\b)-31(.\t.\263, )]TJ 0 Tw 0 -1.143 TD [(\b\002)20(\207\220\221\025\r\013\022)-23.2(\027.\030.)]TJ 8.162 0 0 8.162 157.2493 619.1281 Tm (1)Tj 0.023 Tw 10 0 0 10 70.8661 596.7968 Tm [(\271\213\013\215\017\001\025-\220\006\006)-9.9(\007\016\201\025\r\013\026)11(\016\007\216\006\n\220\203 \220\001\006)-10(\026\220\026)-20(\215)-20(\026 \025\001\n)10(\025\007\025\202\220\220, \032)40(\025\024\006\n\220\203 \213\030\005\226 \033)30(\b\213 \(\221\016\002)-31(.\022)-23.3(\037)31(\025\025\221\016\002\013\026\220\r\001\020\203, \201.\022)-23.3(5, \202)62.1(.\022)-23.3(\032)40(\025\024\006\n, )]TJ 0 -1.2 TD [(63)58(4009, \033\025\006\006\220\205\))]TJ 0 Tw ( )Tj 0.023 Tw 0 -1.2 TD [(\262\210\031\214)42(\240 \253\213\005\030\226 \220\024\016\001\220 \013\n\013\201\016\024\220\ \n\013 \t.\213.\022)-23.2(\005\016\013\007\n\220\001\013\273 \005\220\001\222\201\002\013\r\013 \033\ \025\006\006\220\220 \(\215\007.\022)-23.2(\033\016\017\n\215\001\025\r\006\n\013\205, \201.\022)-23.3(1)113(5, )]TJ 0 -1.2 TD [(\202)62(.\022)-23.3(\213\025\r\025\006\220\f\220\002\006\n, 63005)23(5, \033\025\006\006\220\205\))]TJ 0 Tw ( )Tj 0.023 Tw T* [(\263\021\013\001\n)-10(\026)-41.9(-\034\016\026)11(\016\002\f\215\002\202)10(\006\n\220\203 \202)10(\025\006\215\201\013\002\006)-9.9(\026\r\016\001\001\020\203 \215\001\220\r\016\002\006\220\026)11(\016\026, \024\016\201\220\227\220\001\006\n\220\203 \225\013\n\215\007\216\ )21.1(\026)11(\016\026 \(\240)42(\001\220\r\016\002\006\220\026)11.1(\016\026)21(\006\n\013\205 )]TJ T* [(\001\013\f\016\002\016\217\001\013\205, \201.\022)-23.3(7/9, \202)62(.\022)-23.3(\021\013\001\n)-9.9(\026)-42(-\034\016\026)11(\016\002\f\215\002\202)41(, 1)138(9903)58.1(4, \033\025\006\006\220\205\))]TJ /T1_0 1 Tf 0.041 Tw 9 0 0 9 119.0551 518.293 Tm [(\037\036\035\034: )0.5(\033\032\n\026\021\026\023\025\016\025\032\n\027\026\024\022 )0.6(\t\n\027\032\031\003\031\021\021\020\031 )0.5(\030\026\021\021\020\031 )0.5(\023\025\024\031\032\026\024\205\032\020 )0.5(\n)]TJ /Span<>> BDC ( )Tj EMC 26.235 0 Td [(\013\n\023\n\032\031\013\024\026\023\022\021\n\003 )0.5(\032\026\013\031 )0.5(\(\222\212\212\), \026)]TJ /Span<>> BDC ( )Tj EMC 13.031 0 Td [(\024\026\013\204\031 )0.5(\t\023\205\006\026\025 )]TJ 0.023 Tw -39.266 -1.111 Td (\222\212\212, \026\t\t\n\203\025\025\032\n\027\026\021\021\n\202\n \t)Tj /Span<>> BDC ( )Tj EMC (\005\031\032\031\003\031\021\021\n\t\024\022\007.)Tj 0.135 Tw 0 -1.111 TD (\201\037\215\036\217\220\235 \215)Tj /Span<>> BDC ( )Tj EMC (\240\036\220\255\200\235: \033\032\n\026\021\026\023\025\016\025\032\n\027\ \026\021\020 \023\025\024\031\032\026\024\205\032\021\020\031 \025\t\024\ \n\006\021\025\013\025 \025\016)Tj /Span<>> BDC ( )Tj EMC (\003\031\030\025\203\025\021\t\013\025\004 \005\026\016 \030\026\021\021\ \020\004 PubMed, )Tj 0.095 Tw T* [(MedLine, )0.6(Scopus )0.6(\t)]TJ /Span<>> BDC ( )Tj EMC 7.47 0 Td [(1998 )0.5(\033\n)]TJ /Span<>> BDC ( )Tj EMC 3.636 0 Td [(2023 )0.5(\202\202. )0.6(\212\026\t\t\003\026\024\032\025\027\026\023\025\t\022 )0.7(\r\033\025\030\031\003\025\n\023\n\202\025\006\031\t\013\025\031 )0.6(\026\t\033\031\013\024\020, )0.6(\030\025\026\202\021\n\t\024\025\006\031\t\013\025\031 )0.6(\026\023\202\n)]TJ 0 Tw (-)Tj -0.02 Tw -11.106 -1.111 Td (\032\025\024\003\020, \024\026\013\024\025\013\026 \027\031\030\031\021\025\ \002 \033\026\203\025\031\021\024\n\013, \033\032\n\202\021\n\t\024\025\006\ \031\t\013\025\031 \013\032\025\024\031\032\025\025, \026)Tj /Span<>> BDC ( )Tj EMC (\024\026\013\204\031 \032\031\016\205\023\022\024\026\024\020 \033\n\t\023\ \031 \033\032\n\027\031\030\031\021\021\n\202\n )Tj 0.023 Tw 0 -1.111 TD (\023\031\006\031\021\025\002. \216)Tj /Span<>> BDC ( )Tj EMC (\t\024\026\024\022\007 \027\013\023\007\006\031\021\020 2 \013\023\025\021\ \025\006\031\t\013\025\004 \033\032\025\003\031\032\026 \033\026\203\025\ \031\021\024\n\013 \t)Tj /Span<>> BDC ( )Tj EMC (\222\212\212, \021\026)Tj /Span<>> BDC ( )Tj EMC (\f\n\021\031 \005\031\032\031\003\031\021\021\n\t\024\025.)Tj 0.17 Tw 0 -1.111 TD (\221\201\222\035\223\224\036\217\215\036: \027)Tj /Span<>> BDC ( )Tj EMC (\203\031\023\n\003, \033\032\n\202\021\n\016 \033\032\025)Tj /Span<>> BDC ( )Tj EMC (\013\n\023\n\032\031\013\024\026\023\022\021\n\003 \032\026\013\031 \205\ )Tj /Span<>> BDC ( )Tj EMC (\005\031\032\031\003\031\021\021\020\004 \021\031\005\023\026\202\n\033\032\ \025\002\024\021\020\017, \006\024\n \005\020\027\026\031\024 )Tj 0.039 Tw T* (\t\027\002\016\026\021\n \t)Tj /Span<>> BDC ( )Tj EMC (\021\031\t\027\n\031\027\032\031\003\031\021\021\n\t\024\022\007 \030\025\ \026\202\021\n\t\024\025\013\025, \024\026\013 \013\026\013 \030\025\026\ \202\021\n\016 \205)Tj /Span<>> BDC ( )Tj EMC (\016\021\026\006\025\024\031\023\022\021\n\202\n \006\025\t\023\026 \005\ \031\032\031\003\031\021\021\020\004 \205\t\024\026\021\026\027)Tj 0 Tw (-)Tj 0.079 Tw T* (\023\025\027\026\031\024\t\002 \027)Tj /Span<>> BDC ( )Tj EMC (\030\026\023\031\013\n \016\026\001\031\030\001\031\017 \t\024\026\030\025\ \025 \016\026\005\n\023\031\027\026\021\025\002. \216\n\033\032\n\t\020,\ \013\026\t\026\007\211\025\031\t\002 \024\026\013\024\025\013\025 \027\031\ \030\031\021\025\002 \005\031\032\031\003\031\021\021\n\t\024\025 )Tj 0.02 Tw T* (\025)Tj /Span<>> BDC ( )Tj EMC (\027\020\005\n\032\026 \003\031\024\n\030\026 \023\031\006\031\021\025\002\ \016\023\n\013\026\006\031\t\024\027\031\021\021\n\017 \n\033\205\004\n\ \023\025, \t\n\006\031\024\026\007\211\031\017\t\002 \t)Tj /Span<>> BDC ( )Tj EMC (\005\031\032\031\003\031\021\021\n\t\024\022\007, \006\032\031\016\027\020\ \006\026\017\021\n \t\023\n\204\021\020 )Tj 0.084 Tw T* (\025)Tj /Span<>> BDC ( )Tj EMC (\024\032\205\030\021\n \032\026\016\032\031\001\025\003\020. \240\020 \033\ \032\031\030\t\024\026\027\025\023\025 \t\n\005\t\024\027\031\021\021\020\ \017 \n\033\020\024 \205\t\033\031\001\021\n\202\n \023\031\006\031\021\025\ \002 \030\027\205\004 \033\026\203\025\031\021\024\n\013 \t)Tj /Span<>> BDC ( )Tj EMC (\013\n\023\n\032\031\013)Tj 0 Tw (-)Tj 0.038 Tw T* (\024\026\023\022\021\020\003 \032\026\013\n\003 \021\026)Tj /Span<>> BDC ( )Tj EMC (\f\n\021\031 \005\031\032\031\003\031\021\021\n\t\024\025. \216)Tj /Span<>> BDC ( )Tj EMC (\033\032\025\021\002\024\025\025 \032\031\001\031\021\025\002 \n)Tj /Span<>> BDC ( )Tj EMC (\t\024\032\026\024\031\202\025\025 \023\031\006\031\021\025\002 \203\031\ \023\031\t\n\n\005\032\026\016\021\n \205\006\026\t\024\025\031 )Tj 0.023 Tw T* (\026\013\205\001\031\032\026, \033\031\032\025\021\026\024\n\023\n\202\026\ , \013\n\023\n\032\031\013\024\026\023\022\021\n\202\n \004\025\032\205\032\ \202\026, \032\026\030\025\n\023\n\202\026 \025)Tj /Span<>> BDC ( )Tj EMC (\004\025\003\025\n\024\031\032\026\033\031\027\024\026.)Tj /T1_2 1 Tf 0.01 Tc 0.018 Tw 8 0 0 8 70.9061 383.0237 Tm [(\037\036\035\034\033\032\031\033)5( \030\036\027\032\026:)]TJ /T1_0 1 Tf 0 Tc 0.023 Tw 8.493 0 Td ( \013\n\023\n\032\031\013\024\026\023\022\021\020\017 \032\026\013, \005\ \031\032\031\003\031\021\021\n\t\024\022, \023\031\006\031\021\025\031, \ \033\032\n\202\021\n\016)Tj /T1_2 1 Tf 0.01 Tc 0.018 Tw -8.493 -1.909 Td [(\037\027\025\024\036\023\037\022)5( \023\025\022\033\021\033\030\027\032:)]TJ /T1_0 1 Tf 0 Tc 0.023 Tw 10.401 0 Td ( \026\027\024\n\032\020 \016\026\002\027\023\002\007\024 \n\005 \n\024\t\ \205\024\t\024\027\025\025 \013\n\021\f\023\025\013\024\026 \025\021\024\ \031\032\031\t\n\027)Tj /T1_2 1 Tf 0.034 Tc 0.345 Tw -10.401 -2.617 Td [(\020\036\017)4.9( )0.6(\016\023\022\023\021\027\032\026\025\023\017:)]TJ /T1_3 1 Tf 0.024 Tc 0.35 Tw 9.529 0 Td [( )0.5(\223\036\030\027\t\001\024\r\026)]TJ /Span<>> BDC ( )Tj EMC 6.207 0 Td [(\202.\214., )0.6(\204\026\030\022\024\r\017\004)]TJ /Span<>> BDC ( )Tj EMC 7.494 0 Td [(\200.\202., )0.6(\223\036\030\027\016\022\024\r)]TJ /Span<>> BDC ( )Tj EMC 7.364 0 Td [(\202.\202., )0.5(\025\030\026\f\017\035\034\027\017\022\024\r)]TJ /Span<>> BDC ( )Tj EMC 9.364 0 Td [(\221.\224., )0.6(\234\031\n\036\005\022\017\027\026)]TJ /Span<>> BDC ( )Tj EMC 8.036 0 Td [(\202.\202., )0.6(\230\030\031\013\031\022)]TJ /Span<>> BDC ( )Tj EMC 6.353 0 Td [(\236.\204.,)24( )]TJ 0.023 Tc 0.051 Tw -54.353 -1.2 Td (\212\017\035\034)Tj /Span<>> BDC ( )Tj EMC (\210.\221., \223\036\030\027\t\001\024\r\026)Tj /Span<>> BDC ( )Tj EMC (\202.\213., \202\030\b\017\023\024\r\026)Tj /Span<>> BDC ( )Tj EMC (\247.\222. \025\024\035\024\030\036\022\021\026\035\034\027\t\005 \030\026\ \022 \017)Tj /Span<>> BDC ( )Tj EMC (\002\036\030\036\n\036\027\027\024\f\021\034. )Tj /T1_0 1 Tf -0.023 Tw (\222\n\023\n\033\032\n\013\024\n\023\n\202\025\002.)Tj /T1_3 1 Tf 0.051 Tw ( 2024; \021.)Tj /Span<>> BDC ( )Tj EMC (23, \225)Tj /Span<>> BDC ( )Tj EMC (1, \f.)Tj /Span<>> BDC ( )Tj EMC [(100\226107.)23( )]TJ -0.023 Tw 0 -1.2 TD (https://doi.org/10.33878/2073-7556-2024-23-1-100-107)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0 Tc 0.023 Tw 18 0 0 18 177.6976 295.2774 Tm [(Color)31(ectal cancer and pr)31.1(egnancy)]TJ 0 0 0 1 k /GS1 gs 0 Tw 14 0 0 14 70.8661 270.7734 Tm [(Aly)21(ona\022)-23.2(L.\022)-23.3(Ch)11(erny)10(sh)11(ov)10(a)]TJ 8.162 0 0 8.162 200.2469 275.4354 Tm (1)Tj 0.023 Tw 14 0 0 14 204.8829 270.7734 Tm [(, Vitaliy\022)-23.2(A)-31(.\022)-23.3(Mark)11.1(ovich)]TJ 0 Tw 8.162 0 0 8.162 328.0648 275.4354 Tm (1)Tj 0.023 Tw 14 0 0 14 332.7007 270.7734 Tm [(, Ale)21(x)11(ander\022)-23.2(A)-31(.\022)-23.3(Ch)11(erny)21.1(ak)11(ov)]TJ 0 Tw 8.162 0 0 8.162 486.7669 275.4354 Tm (1)Tj 14 0 0 14 491.4029 270.7734 Tm (, )Tj -30.038 -1.143 Td [(Ser)31(gey\022)-23.2(E.\022)-23.3(Kr)21(asilnik)11.1(ov)]TJ 8.162 0 0 8.162 188.5284 259.4354 Tm (2)Tj 0.023 Tw 14 0 0 14 193.1644 254.7734 Tm [(, Anastasia\022)-23.2(O.\022)-23.3(Sh)11(umeikina)]TJ 0 Tw 8.162 0 0 8.162 341.6439 259.4354 Tm (2)Tj 0.023 Tw 14 0 0 14 346.2799 254.7734 Tm [(, Y)40(ulia M.T)20(r)10(ush)11(uk)]TJ 0 Tw 8.162 0 0 8.162 442.4525 259.4354 Tm (1)Tj 14 0 0 14 447.0885 254.7734 Tm (, )Tj -26.873 -1.143 Td [(Olga\022)-23.3(S.\022)-23.2(Dil)]TJ 8.162 0 0 8.162 133.0332 243.4354 Tm (1)Tj 0.023 Tw 14 0 0 14 137.6692 238.7734 Tm [(, Arina\022)-23.2(E.\022)-23.3(Ch)11(erny)10(sh)11(ov)10(a)]TJ 0 Tw 8.162 0 0 8.162 267.3757 243.4354 Tm (3)Tj 0.023 Tw 14 0 0 14 272.0117 238.7734 Tm [(, Y)50(ana\022)-23.3(I.\022)-23.2(Arkhipov)10(a)]TJ 0 Tw 8.162 0 0 8.162 381.2645 243.4354 Tm (1)Tj 5.83 0 0 5.83 70.8661 224.4342 Tm (1)Tj 0.023 Tw 10 0 0 10 74.1775 221.1042 Tm [(Resear)31(ch Institute of Oncology \(Cooper)21.1(ativ)12(e\022)-23.3(st., 5, T)40(omsk, 63)58(4009, Russia\))]TJ 0 Tw ( )Tj 5.83 0 0 5.83 70.8661 212.4342 Tm (2)Tj 0.023 Tw 10 0 0 10 74.1775 209.1042 Tm [(National Medical Center named af)-30.9(ter Academician E.N.\022)-23.3(Meshalkin \(Rechk)11(unov)10.1(skay)21(a\022)-23.3(st., 1)113.1(5, Nov)10(osibir)20(sk, )]TJ -0.331 -1.2 Td [(63005)23(5, Russia\))]TJ 0 Tw ( )Tj 5.83 0 0 5.83 70.8661 188.4343 Tm (3)Tj 0.023 Tw 10 0 0 10 74.1775 185.1043 Tm [(St. P)10(eter)20.1(sbur)31(g State Univ)12.1(er)20(sit)-20(y \(Univ)12.1(er)20(sitetskay)21.1(a\022)-23.3(st., 7/9, Saint P)10(eter)20.1(sbur)31(g, 1)138(9903)58(4, Russia\))]TJ /T1_0 1 Tf 9 0 0 9 119.0551 166.6003 Tm [(AIM: to analyze recent literature d)26(ata on colorectal cancer \(CR)21(C\) and cases of CR)21(C in p)46(regnant.)]TJ -0.021 Tw 0 -1.111 TD [(P)45(A)45(TIENT)-9.9(S A)53(ND METHODS: PubMed, MedLine, and Scopus medical d)26(atabases 1998\2262023)]TJ /Span<>> BDC ( )Tj EMC [(w)12(ere analyzed. Epidemiology)42(, )]TJ 0.007 Tw T* [(diagnostic algor)-36.9(ithms, patient manag)12.1(ement app)46.1(roach, p)46(rognostic cr)-37(iter)-36.9(ia, as w)12(ell as treatment outcomes w)12.1(ere stud)]TJ 0 Tw (-)Tj 0.023 Tw T* [(ied. The paper includes 2 clinical cases of p)46(regnant patients with CR)21(C with good outcomes.)]TJ -0.017 Tw T* [(C)21(ON)22(CLUSION: )0.6(the )0.5(p)46(rognosis )0.5(for )0.6(colorectal )0.5(cancer )0.6(in )0.5(p)46(regnant )0.5(w)12(omen )0.6(is )0.5(poor )0.5(and )0.5(associated )0.5(with )0.5(late )0.5(diagnostics )0.5(and )]TJ 0.023 Tw 0 -1.111 TD [(adv)16(anced disease. T)56(reatment app)46.1(roach is e)-15(xtremely individual.)]TJ /T1_2 1 Tf 0.01 Tc -0.01 Tw 8 0 0 8 70.906 101.3311 Tm [(KEYW)22(ORDS:)]TJ /T1_0 1 Tf 0 Tc 0.023 Tw 4.948 0 Td [( colorectal cancer)61.1(, p)46(regnancy)42(, treatment, p)46(rognosis)]TJ /T1_2 1 Tf 0.01 Tc 0.018 Tw -4.948 -1.909 Td [(C)19(ONFL)-33(ICT)5( OF)5( INTE)25(RESTS:)]TJ /T1_0 1 Tf 0 Tc 0.023 Tw 10.423 0 Td [( The authors declare no conf)-22(licts of interest)]TJ ET 1 0.68 0 0.12 k /GS0 gs q 1 0 0 1 70.8661 526.7974 cm 0 0 m 0 0 l 0 -11.339 l 42.52 -11.339 l 42.52 0 l h f Q BT 0 0 0 0 k /T1_2 1 Tf 0 Tw 9 0 0 9 76.0071 517.8701 Tm (\021\033\r\035\f\033)Tj ET 1 0.68 0 0.12 k q 1 0 0 1 70.8661 175.1045 cm 0 0 m 0 0 l 0 -11.339 l 42.52 -11.339 l 42.52 0 l h f Q BT 0 0 0 0 k /T1_2 1 Tf 9 0 0 9 73.5728 166.1772 Tm (ABSTRACT)Tj 1 0.68 0 0.12 k /T1_1 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\033\030\031\030\213\b)-20.9(\035\231\213\233\t \021\032)50(\b)42(\032\231\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj -51.938 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 23, \023\0221)69(, 202)69(4)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 23, \023\0221)69(, 202)69(4)]TJ /T1_4 1 Tf 25 0 0 25 20.7653 56.0378 Tm (100)Tj ET q 0 g 0 G 0 j 0 J /Fm1 Do Q 0 0 0 0 k 396.85 725.67 59.155 11.338 re f /PlacedPDF /MC0 BDC q 397.481 736.808 m 397.242 736.808 397.049 736.616 397.049 736.376 c 397.049 736.376 l 397.049 726.285 l 397.049 726.045 397.242 725.853 397.481 725.853 c 397.481 725.853 l 455.382 725.853 l 455.62 725.853 455.815 726.045 455.815 726.285 c 455.815 726.285 l 455.815 736.376 l 455.815 736.616 455.62 736.808 455.382 736.808 c 455.382 736.808 l h W n q 0 g -0.0000005 -10.9560913 -10.9560913 0.0000005 426.4320445 736.8086309 cm BX /Sh0 sh EX Q Q q 396.85 725.67 59.155 11.337 re W n 0 0 0 0.84 k q 1 0 0 1 413.5634 732.4249 cm 0 0 m -0.025 0.1 -0.063 0.196 -0.112 0.287 c -0.157 0.374 -0.218 0.451 -0.292 0.515 c -0.37 0.582 -0.46 0.632 -0.558 0.664 c -0.669 0.701 -0.786 0.719 -0.903 0.717 c -1.076 0.722 -1.247 0.681 -1.4 0.6 c -1.536 0.526 -1.652 0.42 -1.74 0.292 c -1.83 0.158 -1.895 0.008 -1.934 -0.149 c -2.018 -0.48 -2.018 -0.827 -1.934 -1.158 c -1.896 -1.316 -1.83 -1.466 -1.74 -1.602 c -1.653 -1.731 -1.536 -1.837 -1.4 -1.912 c -1.247 -1.993 -1.076 -2.033 -0.903 -2.029 c -0.774 -2.032 -0.647 -2.006 -0.528 -1.955 c -0.427 -1.906 -0.337 -1.837 -0.263 -1.753 c -0.185 -1.665 -0.124 -1.563 -0.082 -1.453 c -0.034 -1.338 0 -1.218 0.019 -1.094 c 0.635 -1.094 l 0.624 -1.297 0.578 -1.497 0.497 -1.684 c 0.421 -1.857 0.312 -2.015 0.175 -2.146 c 0.039 -2.277 -0.123 -2.379 -0.3 -2.446 c -0.492 -2.519 -0.695 -2.555 -0.9 -2.552 c -1.15 -2.557 -1.397 -2.506 -1.625 -2.404 c -1.829 -2.307 -2.01 -2.169 -2.157 -1.997 c -2.308 -1.821 -2.423 -1.617 -2.497 -1.397 c -2.655 -0.924 -2.655 -0.412 -2.497 0.061 c -2.423 0.281 -2.307 0.485 -2.157 0.661 c -2.01 0.833 -1.829 0.973 -1.625 1.07 c -1.398 1.174 -1.15 1.226 -0.9 1.222 c -0.707 1.223 -0.515 1.196 -0.329 1.14 c -0.159 1.088 0.001 1.006 0.144 0.898 c 0.278 0.793 0.39 0.662 0.473 0.513 c 0.562 0.349 0.615 0.167 0.629 -0.019 c 0 -0.019 l 0 0 l f Q q 1 0 0 1 414.6923 733.5723 cm 0 0 m 0.584 0 l 0.584 -1.328 l 0.662 -1.204 0.771 -1.103 0.9 -1.033 c 1.046 -0.951 1.213 -0.91 1.381 -0.914 c 1.627 -0.9 1.869 -0.979 2.058 -1.137 c 2.234 -1.312 2.325 -1.556 2.305 -1.803 c 2.305 -3.596 l 1.716 -3.596 l 1.716 -1.976 l 1.724 -1.817 1.678 -1.66 1.585 -1.53 c 1.486 -1.43 1.347 -1.379 1.206 -1.392 c 1.114 -1.39 1.024 -1.408 0.94 -1.445 c 0.865 -1.479 0.798 -1.529 0.744 -1.591 c 0.687 -1.656 0.645 -1.73 0.616 -1.812 c 0.586 -1.896 0.571 -1.986 0.571 -2.077 c 0.571 -3.615 l 0 -3.615 l 0 0 l f Q q 1 0 0 1 418.0385 731.1235 cm 0 0 m 0 -0.099 0.014 -0.198 0.043 -0.292 c 0.069 -0.382 0.112 -0.466 0.17 -0.54 c 0.229 -0.611 0.304 -0.669 0.388 -0.709 c 0.486 -0.754 0.594 -0.776 0.702 -0.773 c 0.845 -0.78 0.987 -0.742 1.108 -0.664 c 1.217 -0.582 1.296 -0.468 1.336 -0.337 c 1.881 -0.337 l 1.827 -0.603 1.675 -0.838 1.456 -0.996 c 1.35 -1.073 1.231 -1.131 1.105 -1.169 c 0.971 -1.208 0.831 -1.229 0.691 -1.227 c 0.509 -1.227 0.328 -1.191 0.16 -1.121 c 0.007 -1.063 -0.13 -0.972 -0.244 -0.855 c -0.356 -0.73 -0.44 -0.583 -0.491 -0.422 c -0.548 -0.243 -0.576 -0.056 -0.574 0.133 c -0.575 0.313 -0.545 0.493 -0.486 0.664 c -0.426 0.826 -0.335 0.974 -0.22 1.102 c 0.004 1.375 0.338 1.534 0.691 1.535 c 0.883 1.539 1.072 1.495 1.243 1.408 c 1.402 1.326 1.541 1.209 1.649 1.067 c 1.759 0.922 1.838 0.757 1.883 0.582 c 1.932 0.396 1.945 0.203 1.92 0.013 c 0 0.013 l 0 0 l 1.342 0.377 m 1.335 0.468 1.315 0.557 1.283 0.643 c 1.253 0.724 1.209 0.798 1.153 0.863 c 1.097 0.922 1.03 0.97 0.957 1.004 c 0.874 1.043 0.783 1.063 0.691 1.062 c 0.6 1.062 0.509 1.044 0.425 1.009 c 0.345 0.976 0.273 0.926 0.213 0.863 c 0.153 0.799 0.105 0.724 0.072 0.643 c 0.037 0.559 0.017 0.468 0.014 0.377 c 1.355 0.377 l h f Q q 1 0 0 1 422.1581 731.7051 cm 0 0 m -0.012 0.144 -0.082 0.276 -0.194 0.366 c -0.31 0.452 -0.451 0.495 -0.595 0.489 c -0.675 0.488 -0.755 0.476 -0.831 0.452 c -0.918 0.424 -0.998 0.375 -1.062 0.311 c -1.142 0.229 -1.202 0.131 -1.24 0.024 c -1.29 -0.132 -1.312 -0.296 -1.304 -0.459 c -1.304 -0.569 -1.292 -0.677 -1.267 -0.784 c -1.244 -0.885 -1.202 -0.983 -1.145 -1.07 c -1.09 -1.154 -1.016 -1.224 -0.93 -1.275 c -0.833 -1.33 -0.722 -1.356 -0.611 -1.352 c -0.457 -1.357 -0.307 -1.301 -0.194 -1.195 c -0.078 -1.077 -0.005 -0.922 0.011 -0.757 c 0.587 -0.757 l 0.556 -1.055 0.419 -1.332 0.202 -1.538 c -0.022 -1.721 -0.306 -1.815 -0.595 -1.803 c -0.777 -1.806 -0.958 -1.771 -1.126 -1.7 c -1.293 -1.642 -1.445 -1.547 -1.57 -1.421 c -1.68 -1.297 -1.763 -1.151 -1.814 -0.993 c -1.87 -0.822 -1.898 -0.643 -1.896 -0.462 c -1.898 -0.276 -1.871 -0.091 -1.817 0.087 c -1.766 0.252 -1.682 0.405 -1.57 0.537 c -1.459 0.664 -1.323 0.766 -1.168 0.834 c -0.991 0.914 -0.798 0.955 -0.603 0.954 c -0.457 0.954 -0.311 0.935 -0.17 0.895 c -0.039 0.858 0.084 0.799 0.194 0.72 c 0.302 0.643 0.393 0.543 0.459 0.428 c 0.531 0.298 0.572 0.155 0.582 0.008 c 0 0.008 l 0 0 l f Q q 1 0 0 1 423.2177 733.5723 cm 0 0 m 0.577 0 l 0.577 -2.048 l 1.615 -0.985 l 2.322 -0.985 l 1.323 -1.944 l 2.417 -3.604 l 1.716 -3.604 l 0.919 -2.337 l 0.577 -2.669 l 0.577 -3.604 l 0 -3.604 l h f Q q 1 0 0 1 427.0585 732.5762 cm 0 0 m 0.436 0 l 0.436 0.218 l 0.429 0.352 0.448 0.486 0.488 0.614 c 0.521 0.705 0.577 0.786 0.651 0.85 c 0.717 0.905 0.795 0.943 0.879 0.961 c 0.966 0.979 1.056 0.988 1.145 0.988 c 1.28 0.993 1.416 0.981 1.548 0.954 c 1.548 0.505 l 1.509 0.516 1.469 0.523 1.429 0.528 c 1.379 0.532 1.33 0.532 1.28 0.528 c 1.209 0.53 1.14 0.511 1.081 0.473 c 1.019 0.419 0.987 0.337 0.999 0.255 c 0.999 -0.011 l 1.498 -0.011 l 1.498 -0.441 l 1.009 -0.441 l 1.009 -2.622 l 0.436 -2.622 l 0.436 -0.428 l 0.005 -0.428 l 0.005 0 l 0 0 l f Q q 1 0 0 1 430.1 729.8965 cm 0 0 m -0.191 -0.003 -0.381 0.032 -0.559 0.104 c -0.715 0.167 -0.856 0.264 -0.972 0.388 c -1.091 0.512 -1.181 0.659 -1.238 0.82 c -1.356 1.18 -1.356 1.567 -1.238 1.925 c -1.181 2.087 -1.091 2.234 -0.972 2.358 c -0.856 2.481 -0.715 2.578 -0.559 2.643 c -0.199 2.78 0.198 2.78 0.558 2.643 c 0.714 2.578 0.855 2.481 0.972 2.358 c 1.09 2.234 1.181 2.087 1.237 1.925 c 1.355 1.567 1.355 1.18 1.237 0.82 c 1.181 0.659 1.09 0.512 0.972 0.388 c 0.855 0.266 0.713 0.169 0.558 0.106 c 0.38 0.034 0.191 -0.002 0 0 c 0 0.454 m 0.115 0.451 0.23 0.479 0.332 0.534 c 0.424 0.586 0.502 0.659 0.562 0.746 c 0.624 0.836 0.669 0.936 0.695 1.041 c 0.752 1.26 0.752 1.491 0.695 1.71 c 0.669 1.816 0.625 1.916 0.562 2.005 c 0.502 2.091 0.423 2.163 0.332 2.215 c 0.123 2.323 -0.126 2.323 -0.335 2.215 c -0.427 2.163 -0.505 2.091 -0.566 2.005 c -0.628 1.916 -0.673 1.816 -0.699 1.71 c -0.756 1.491 -0.756 1.26 -0.699 1.041 c -0.672 0.936 -0.627 0.836 -0.566 0.746 c -0.506 0.659 -0.427 0.586 -0.335 0.534 c -0.232 0.478 -0.117 0.451 0 0.454 c f Q q 1 0 0 1 431.8979 732.5762 cm 0 0 m 0.531 0 l 0.531 -0.505 l 0.55 -0.43 0.583 -0.359 0.629 -0.297 c 0.681 -0.229 0.74 -0.167 0.807 -0.114 c 0.877 -0.059 0.956 -0.014 1.039 0.019 c 1.123 0.053 1.213 0.07 1.304 0.069 c 1.52 0.069 l 1.52 -0.486 l 1.395 -0.467 l 1.269 -0.467 l 1.178 -0.468 1.087 -0.488 1.004 -0.526 c 0.917 -0.565 0.839 -0.625 0.778 -0.699 c 0.716 -0.783 0.669 -0.878 0.643 -0.98 c 0.604 -1.104 0.584 -1.233 0.586 -1.362 c 0.586 -2.603 l 0.01 -2.603 l 0.01 0 l 0 0 l f Q q 1 0 0 1 437.3666 729.9683 cm 0 0 m -0.577 0 l -0.577 0.364 l -0.649 0.23 -0.759 0.121 -0.893 0.047 c -1.022 -0.029 -1.169 -0.07 -1.32 -0.072 c -1.595 -0.095 -1.866 0.002 -2.064 0.194 c -2.234 0.413 -2.316 0.687 -2.295 0.964 c -2.295 2.608 l -1.719 2.608 l -1.719 1.014 l -1.735 0.843 -1.689 0.67 -1.588 0.531 c -1.492 0.433 -1.357 0.382 -1.219 0.39 c -1.116 0.387 -1.012 0.406 -0.917 0.446 c -0.84 0.479 -0.772 0.531 -0.72 0.595 c -0.667 0.661 -0.63 0.738 -0.611 0.82 c -0.588 0.911 -0.577 1.003 -0.577 1.097 c -0.577 2.611 l 0 2.611 l 0 0 l f Q q 1 0 0 1 437.9877 732.5762 cm 0 0 m 0.545 0 l 0.545 -0.353 l 0.617 -0.209 0.736 -0.094 0.882 -0.026 c 1.03 0.04 1.19 0.073 1.352 0.072 c 1.535 0.075 1.717 0.038 1.883 -0.037 c 2.031 -0.106 2.161 -0.208 2.263 -0.334 c 2.366 -0.465 2.442 -0.615 2.489 -0.775 c 2.54 -0.948 2.566 -1.127 2.566 -1.307 c 2.566 -1.479 2.542 -1.651 2.497 -1.817 c 2.455 -1.973 2.385 -2.121 2.29 -2.252 c 2.099 -2.522 1.789 -2.682 1.458 -2.68 c 1.369 -2.681 1.28 -2.674 1.193 -2.659 c 1.11 -2.644 1.028 -2.618 0.951 -2.584 c 0.875 -2.552 0.802 -2.509 0.736 -2.457 c 0.671 -2.406 0.615 -2.343 0.571 -2.273 c 0.571 -3.575 l -0.005 -3.575 l -0.005 0 l 0 0 l 2.008 -1.307 m 2.008 -1.191 1.993 -1.076 1.963 -0.964 c 1.936 -0.859 1.89 -0.759 1.828 -0.669 c 1.768 -0.584 1.69 -0.514 1.599 -0.462 c 1.503 -0.409 1.395 -0.382 1.286 -0.385 c 1.072 -0.372 0.867 -0.467 0.738 -0.638 c 0.607 -0.836 0.543 -1.072 0.555 -1.31 c 0.554 -1.433 0.57 -1.557 0.603 -1.676 c 0.631 -1.781 0.68 -1.879 0.747 -1.965 c 0.809 -2.044 0.886 -2.109 0.975 -2.157 c 1.071 -2.206 1.178 -2.23 1.286 -2.229 c 1.401 -2.232 1.517 -2.205 1.618 -2.148 c 1.708 -2.096 1.785 -2.025 1.843 -1.939 c 1.903 -1.85 1.945 -1.751 1.968 -1.646 c 1.995 -1.535 2.008 -1.421 2.008 -1.307 c f Q q 1 0 0 1 443.5127 729.9683 cm 0 0 m -0.545 0 l -0.545 0.353 l -0.616 0.211 -0.734 0.099 -0.879 0.034 c -1.027 -0.031 -1.187 -0.065 -1.349 -0.064 c -1.532 -0.067 -1.714 -0.03 -1.88 0.045 c -2.028 0.113 -2.158 0.214 -2.26 0.34 c -2.364 0.47 -2.441 0.62 -2.486 0.781 c -2.538 0.958 -2.564 1.143 -2.563 1.328 c -2.568 1.536 -2.536 1.742 -2.468 1.938 c -2.41 2.097 -2.319 2.242 -2.202 2.364 c -2.101 2.471 -1.977 2.555 -1.838 2.608 c -1.705 2.659 -1.563 2.685 -1.421 2.685 c -1.338 2.685 -1.256 2.678 -1.174 2.664 c -1.091 2.648 -1.01 2.624 -0.932 2.589 c -0.855 2.556 -0.783 2.514 -0.717 2.462 c -0.652 2.411 -0.597 2.349 -0.553 2.279 c -0.553 3.606 l 0.024 3.606 l 0.024 0 l 0 0 l -2.008 1.277 m -2.009 1.166 -1.994 1.056 -1.965 0.948 c -1.939 0.845 -1.896 0.748 -1.835 0.661 c -1.777 0.578 -1.699 0.508 -1.61 0.459 c -1.404 0.355 -1.162 0.355 -0.956 0.459 c -0.866 0.512 -0.789 0.585 -0.73 0.671 c -0.671 0.762 -0.626 0.862 -0.6 0.966 c -0.572 1.076 -0.558 1.188 -0.558 1.301 c -0.543 1.542 -0.612 1.781 -0.751 1.979 c -0.88 2.14 -1.078 2.229 -1.283 2.22 c -1.402 2.224 -1.52 2.196 -1.623 2.138 c -1.714 2.083 -1.793 2.009 -1.852 1.92 c -1.911 1.828 -1.954 1.725 -1.977 1.617 c -1.999 1.505 -2.01 1.392 -2.008 1.277 c f Q q 1 0 0 1 446.3252 730.5499 cm 0 0 m -0.004 -0.052 0.005 -0.104 0.026 -0.151 c 0.052 -0.185 0.094 -0.202 0.136 -0.197 c 0.197 -0.197 l 0.223 -0.2 0.25 -0.2 0.276 -0.197 c 0.276 -0.595 l 0.199 -0.619 l 0.101 -0.64 l 0 -0.656 l -0.085 -0.656 l -0.187 -0.66 -0.288 -0.635 -0.377 -0.584 c -0.461 -0.528 -0.516 -0.437 -0.528 -0.337 c -0.648 -0.451 -0.792 -0.534 -0.951 -0.579 c -1.106 -0.628 -1.269 -0.654 -1.432 -0.656 c -1.546 -0.657 -1.659 -0.641 -1.769 -0.608 c -1.872 -0.579 -1.967 -0.531 -2.053 -0.468 c -2.136 -0.405 -2.203 -0.324 -2.25 -0.231 c -2.3 -0.127 -2.326 -0.012 -2.324 0.104 c -2.33 0.24 -2.299 0.375 -2.236 0.497 c -2.181 0.594 -2.101 0.675 -2.005 0.733 c -1.905 0.791 -1.795 0.833 -1.681 0.855 c -1.562 0.88 -1.442 0.899 -1.32 0.914 c -1.222 0.933 -1.123 0.947 -1.022 0.956 c -0.938 0.963 -0.855 0.977 -0.773 0.999 c -0.708 1.014 -0.649 1.046 -0.6 1.092 c -0.556 1.144 -0.533 1.211 -0.536 1.28 c -0.534 1.344 -0.553 1.408 -0.59 1.46 c -0.624 1.507 -0.668 1.544 -0.72 1.569 c -0.775 1.596 -0.834 1.613 -0.895 1.62 c -0.955 1.624 -1.016 1.624 -1.076 1.62 c -1.215 1.625 -1.354 1.591 -1.474 1.519 c -1.581 1.45 -1.647 1.333 -1.652 1.206 c -2.231 1.206 l -2.227 1.354 -2.185 1.498 -2.108 1.625 c -2.041 1.733 -1.951 1.824 -1.843 1.891 c -1.729 1.96 -1.603 2.007 -1.472 2.032 c -1.329 2.072 -1.183 2.098 -1.036 2.109 c -0.908 2.109 -0.781 2.096 -0.656 2.069 c -0.538 2.044 -0.425 2 -0.321 1.939 c -0.225 1.88 -0.143 1.8 -0.083 1.705 c -0.02 1.599 0.012 1.478 0.008 1.354 c 0.008 0.013 l 0 0 l -0.576 0.728 m -0.674 0.667 -0.785 0.631 -0.9 0.624 c -1.028 0.612 -1.155 0.594 -1.283 0.571 c -1.343 0.561 -1.402 0.547 -1.46 0.528 c -1.515 0.511 -1.566 0.485 -1.612 0.451 c -1.657 0.419 -1.692 0.376 -1.716 0.327 c -1.742 0.267 -1.755 0.203 -1.753 0.138 c -1.755 0.079 -1.735 0.021 -1.697 -0.024 c -1.661 -0.067 -1.615 -0.103 -1.564 -0.127 c -1.509 -0.154 -1.451 -0.171 -1.392 -0.181 c -1.335 -0.19 -1.278 -0.196 -1.222 -0.197 c -1.152 -0.196 -1.083 -0.188 -1.015 -0.173 c -0.94 -0.156 -0.87 -0.127 -0.805 -0.088 c -0.74 -0.048 -0.684 0.004 -0.64 0.066 c -0.594 0.134 -0.571 0.215 -0.574 0.297 c -0.574 0.725 l h f Q q 1 0 0 1 446.6836 732.5762 cm 0 0 m 0.434 0 l 0.434 0.784 l 0.996 0.784 l 0.996 0 l 1.527 0 l 1.527 -0.43 l 0.996 -0.43 l 0.996 -1.822 l 0.993 -1.874 0.993 -1.927 0.996 -1.979 c 1 -2.018 1.011 -2.056 1.031 -2.09 c 1.05 -2.122 1.079 -2.146 1.113 -2.159 c 1.162 -2.177 1.213 -2.185 1.265 -2.183 c 1.387 -2.183 l 1.428 -2.181 1.469 -2.175 1.509 -2.165 c 1.509 -2.608 l 1.323 -2.629 l 1.261 -2.633 1.199 -2.633 1.137 -2.629 c 1.013 -2.633 0.89 -2.619 0.771 -2.587 c 0.688 -2.564 0.613 -2.52 0.553 -2.459 c 0.499 -2.4 0.462 -2.328 0.446 -2.25 c 0.427 -2.155 0.416 -2.059 0.415 -1.963 c 0.415 -0.428 l -0.019 -0.428 l -0.019 0 l 0 0 l f Q q 1 0 0 1 449.0742 731.1235 cm 0 0 m 0 -0.099 0.014 -0.198 0.042 -0.292 c 0.068 -0.382 0.112 -0.466 0.17 -0.54 c 0.229 -0.611 0.303 -0.669 0.388 -0.709 c 0.486 -0.754 0.593 -0.776 0.701 -0.773 c 0.845 -0.78 0.987 -0.742 1.107 -0.664 c 1.216 -0.582 1.296 -0.468 1.336 -0.337 c 1.88 -0.337 l 1.827 -0.603 1.674 -0.838 1.456 -0.996 c 1.349 -1.073 1.231 -1.131 1.105 -1.169 c 0.973 -1.208 0.836 -1.228 0.699 -1.227 c 0.512 -1.23 0.327 -1.196 0.154 -1.126 c 0.003 -1.066 -0.133 -0.973 -0.244 -0.855 c -0.356 -0.73 -0.44 -0.583 -0.491 -0.422 c -0.548 -0.243 -0.576 -0.056 -0.574 0.133 c -0.575 0.313 -0.546 0.493 -0.486 0.664 c -0.426 0.826 -0.336 0.974 -0.221 1.102 c 0.002 1.374 0.334 1.532 0.685 1.535 c 0.877 1.539 1.067 1.495 1.238 1.408 c 1.396 1.326 1.535 1.209 1.644 1.067 c 1.753 0.922 1.833 0.757 1.878 0.582 c 1.927 0.396 1.939 0.203 1.915 0.013 c -0.002 0.013 l 0 0 l 1.341 0.377 m 1.335 0.468 1.315 0.557 1.283 0.643 c 1.253 0.724 1.209 0.798 1.153 0.863 c 1.096 0.926 1.027 0.978 0.951 1.014 c 0.868 1.054 0.777 1.074 0.685 1.073 c 0.594 1.073 0.504 1.055 0.419 1.02 c 0.339 0.986 0.267 0.937 0.207 0.874 c 0.147 0.81 0.099 0.735 0.066 0.653 c 0.031 0.569 0.011 0.479 0.008 0.388 c 1.349 0.388 l h f Q q 1 0 0 1 451.8657 730.7994 cm 0 0 m 0.002 -0.142 0.073 -0.274 0.191 -0.353 c 0.312 -0.423 0.45 -0.458 0.59 -0.454 c 0.651 -0.458 0.711 -0.458 0.773 -0.454 c 0.839 -0.447 0.904 -0.43 0.967 -0.406 c 1.024 -0.385 1.075 -0.349 1.116 -0.303 c 1.155 -0.252 1.174 -0.189 1.168 -0.125 c 1.166 -0.057 1.138 0.008 1.089 0.056 c 1.033 0.107 0.967 0.146 0.895 0.17 c 0.809 0.201 0.72 0.226 0.629 0.245 c 0.329 0.33 l 0.224 0.352 0.121 0.38 0.019 0.415 c -0.076 0.446 -0.166 0.491 -0.247 0.55 c -0.327 0.608 -0.391 0.683 -0.436 0.771 c -0.486 0.873 -0.511 0.986 -0.507 1.1 c -0.512 1.226 -0.475 1.351 -0.404 1.456 c -0.333 1.551 -0.243 1.63 -0.138 1.687 c -0.028 1.747 0.092 1.788 0.215 1.809 c 0.337 1.832 0.462 1.843 0.587 1.843 c 0.716 1.844 0.845 1.83 0.972 1.801 c 1.09 1.774 1.202 1.727 1.304 1.663 c 1.404 1.598 1.488 1.513 1.551 1.413 c 1.621 1.3 1.663 1.173 1.676 1.041 c 1.076 1.041 l 1.059 1.155 0.989 1.253 0.887 1.307 c 0.78 1.355 0.665 1.38 0.547 1.378 c 0.5 1.381 0.452 1.381 0.403 1.378 c 0.35 1.373 0.298 1.36 0.247 1.341 c 0.2 1.325 0.157 1.297 0.122 1.262 c 0.087 1.224 0.069 1.174 0.071 1.124 c 0.069 1.058 0.096 0.995 0.146 0.951 c 0.202 0.903 0.267 0.866 0.337 0.842 c 0.424 0.811 0.512 0.786 0.603 0.768 c 0.917 0.701 l 1.021 0.678 1.124 0.65 1.224 0.616 c 1.319 0.584 1.409 0.539 1.49 0.481 c 1.662 0.359 1.762 0.16 1.755 -0.05 c 1.76 -0.189 1.723 -0.326 1.649 -0.443 c 1.582 -0.551 1.491 -0.642 1.384 -0.709 c 1.267 -0.778 1.14 -0.827 1.007 -0.855 c 0.873 -0.885 0.735 -0.9 0.598 -0.9 c 0.443 -0.902 0.29 -0.883 0.141 -0.845 c 0.01 -0.812 -0.114 -0.753 -0.223 -0.674 c -0.324 -0.601 -0.407 -0.504 -0.465 -0.393 c -0.527 -0.269 -0.559 -0.131 -0.558 0.008 c 0.019 0.008 l 0 0 l f Q 0.146 0.941 0.992 0.044 k q 1 0 0 1 401.2527 729.3892 cm 0 0 m 3.612 2.406 l 3.612 5.296 l 0 5.296 l h f Q 0 0.889 0.676 0 k q 1 0 0 1 404.865 729.3892 cm 0 0 m -3.612 2.406 l -3.612 5.296 l 0 5.296 l h f Q 0.694 0.076 0.209 0 k q 1 0 0 1 403.0589 735.3145 cm 0 0 m -2.2 0 -3.984 -1.784 -3.984 -3.984 c -3.984 -6.184 -2.2 -7.968 0 -7.968 c 2.2 -7.968 3.984 -6.184 3.984 -3.984 c 3.984 -1.784 2.2 0 0 0 c 0 -6.993 m -1.662 -6.993 -3.009 -5.646 -3.009 -3.984 c -3.009 -2.322 -1.662 -0.975 0 -0.975 c 1.662 -0.975 3.009 -2.322 3.009 -3.984 c 3.009 -5.646 1.662 -6.993 0 -6.993 c f Q 0 0.235 0.86 0 k q 1 0 0 1 405.2601 729.2803 cm 0 0 m -1.118 -1.208 -3.015 -1.281 -4.237 -0.159 c -5.159 0.688 -5.459 2.005 -4.999 3.156 c -5.833 3.687 l -6.736 1.681 -5.843 -0.679 -3.836 -1.582 c -2.218 -2.311 -0.312 -1.881 0.836 -0.528 c 0 0 l f Q 0 0 0 0.6 k q 1 0 0 1 397.4813 736.8087 cm 0 0 m -0.238 0 -0.432 -0.193 -0.432 -0.432 c -0.432 -10.524 l -0.432 -10.763 -0.238 -10.956 0 -10.956 c 57.901 -10.956 l 58.139 -10.956 58.333 -10.763 58.333 -10.524 c 58.333 -0.432 l 58.333 -0.193 58.139 0 57.901 0 c h 57.901 -11.155 m 0 -11.155 l -0.348 -11.155 -0.631 -10.872 -0.631 -10.524 c -0.631 -0.432 l -0.631 -0.084 -0.348 0.199 0 0.199 c 57.901 0.199 l 58.249 0.199 58.532 -0.084 58.532 -0.432 c 58.532 -10.524 l 58.532 -10.872 58.249 -11.155 57.901 -11.155 c f Q EMC Q endstream endobj 1501 0 obj <> endobj 1503 0 obj <>stream Adobe Illustrator CS6 (Windows) 2021-04-12T11:45:36+05:00 2021-06-02T10:28:09+05:00 2021-06-02T10:28:09+05:00 1 False False 20.868494 3.999928 Millimeters Cyan Magenta Yellow Black Default Swatch Group 0 C=0 M=24 Y=86 K=0 PROCESS 100.000000 CMYK 0.000000 23.504999 86.022697 0.000000 C=69 M=8 Y=21 K=0 PROCESS 100.000000 CMYK 69.369003 7.635600 20.892700 0.000000 C=0 M=89 Y=68 K=0 PROCESS 100.000000 CMYK 0.000000 88.946404 67.623398 0.000000 C=15 M=94 Y=99 K=4 PROCESS 100.000000 CMYK 14.578501 94.070297 99.160698 4.416000 C=0 M=0 Y=0 K=84 PROCESS 100.000000 CMYK 0.000000 0.000000 0.000000 84.000000 C=0 M=0 Y=0 K=35 PROCESS 100.000000 CMYK 0.000000 0.000000 0.000000 35.000000 C=0 M=0 Y=0 K=60 PROCESS 100.000000 CMYK 0.000000 0.000000 0.000000 60.000004 Document application/pdf proof:pdf xmp.did:804244B35A9BEB118A6FC3C256996E2F uuid:08e30110-bdb7-4606-97ca-63fb62cbcecc uuid:21079f76-f6d7-4329-b725-f2fb35af5114 uuid:722f8893-0b3c-4402-87fb-c713f1fa0e26 uuid:21079f76-f6d7-4329-b725-f2fb35af5114 uuid:21079f76-f6d7-4329-b725-f2fb35af5114 proof:pdf saved xmp.iid:804244B35A9BEB118A6FC3C256996E2F 2021-04-12T11:45:42+05:00 Adobe Illustrator CS6 (Windows) / endstream endobj 1502 0 obj <>/Border[0 0 0]/H/N/Rect[394.85 739.008 458.005 723.67]/Subtype/Link/Type/Annot>> endobj 1504 0 obj <> endobj 1497 0 obj [1505 0 R 1506 0 R 1507 0 R 1508 0 R 1509 0 R 1510 0 R 1511 0 R 1512 0 R 1513 0 R 1514 0 R 1515 0 R 1516 0 R 1517 0 R 1518 0 R 1519 0 R 1520 0 R 1521 0 R 1522 0 R 1523 0 R 1524 0 R 1525 0 R 1526 0 R 1527 0 R 1528 0 R 1529 0 R 1530 0 R 1531 0 R 1532 0 R 1533 0 R 1534 0 R 1535 0 R 1536 0 R 1537 0 R 1538 0 R] endobj 1498 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(IC)31(G-\013\001\202\220\025\202\002\013\225\220\205 \r\022\025\227\016\001\n\016\ \n\013\017\016\006)-10(\026\r\013 \225\025\002\024\220\002\025\r\013\001\220\205 )]TJ 0 -1 TD [(\221\025\007\001\025\006)-9.9(\007\025\203\001\025\202)10(\025 \221\002\205\024\025\n\220\016\017\001\025\202)10(\025 \007\025\006\n\215)-19.9(\026)11(\013 \221\002\220\022\025\221\016\002\013\026\220\r\001\025\024 )]TJ T* [(\007\016\017\016\001\220\220 \006)-10(\007\025\217\001\020\207 \221\002\205\024\025\n\220\016\017\001\020\207\ \006\r\220\224\016\203)]TJ 31.181 2 Td [(IC)31(G-angiogr)21.1(aph)31(y for r)31(ectal adv)10(ancement flap in patients with anal f)-21(istulas)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0.002 Tc 0.349 Tw 8 0 0 8 42.5197 731.2159 Tm [(v)0.5(e)0.6(s)0.5(s)0.5(e)0.5(l)0.6( i)0.5(n)0.6( b)0.5(a)0.5(r)-36.4(i)0.5(a)15.5(t)0.6(r)-36.5(i)0.5(c)0.6( s)0.5(u)0.6(r)-31.5(g)0.5(e)0.5(r)-23.4(y)0.5(.)0.5( )]TJ /T1_2 1 Tf [(O)0.5(b)0.5(e)0.6(s)0.5( S)0.6(u)0.5(r)0.5(g)0.5(.)]TJ /T1_1 1 Tf 16.824 0 Td [( 2)0.5(0)0.5(2)0.5(0)0.5(;)0.6(3)0.5(0)0.5(\()0.5(1)0.5(2)0.5(\))0.6(:)0.5(5)0.5(1)0.5(6)0.6(7)0.5(\226)0.5(5)0.5(1)0.5(6)0.6(9)0.5(.)2( )]TJ 0 Tc 0 Tw -16.824 -1.25 Td [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1007/s11695-020-04949-8)Tj 0 0 0 1 k /GS1 gs 0.074 Tw -1.847 -1.25 Td (14.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Jo)-16(osten)]TJ /Span<>> BDC ( )Tj EMC [(JJ, S)-15.9(l)30(o)-16(o)17(ter)]TJ /Span<>> BDC ( )Tj EMC [(MD, v)-15(an den El)-39.9(zen)]TJ /Span<>> BDC ( )Tj EMC [(RM, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. U)13(nder)-10(st)15(anding )]TJ 0.112 Tw -1.796 -1.25 Td [(fl)35(uor)-23.9(escence t)-32(ime cur)-32(ves dur)-37(ing ileal pouch-anal anast)17.1(omosis wi)-23.9(t)-13(h )]TJ 0.163 Tw 0 -1.25 TD [(or )0.5(wi)-24(t)-13(hout )0.5(v)-15(ascul)-15.9(ar )0.5(l)-31(iga)15(t)-32(ion. )]TJ /T1_2 1 Tf 12.398 0 Td [(Surg )0.5(Endosc.)]TJ /T1_1 1 Tf [( )0.5(2023;37\(7\):5086\2265093. )]TJ 0 Tw -12.398 -1.25 Td [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1007/s00464-023-09921-y)Tj 0 0 0 1 k /GS1 gs 0.232 Tw -1.847 -1.25 Td (15.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(P)35(r)-37(imo-R)11.1(oma)-17(guer)-33(a)]TJ /Span<>> BDC ( )Tj EMC [(V, L)35(opez)]TJ /Span<>> BDC ( )Tj EMC [(DP, Al)30(v)-14.9(ar)-24(ez-Sar)-24(r)-32.9(ad)-16(o)]TJ /Span<>> BDC ( )Tj EMC [(E, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. F)10(ull-)]TJ 0.095 Tw -1.796 -1.25 Td [(t)-13(hickness r)-23.9(ec)-16(t)15(al ad)-17(v)-14.9(ancement fl)-15.9(ap for com)10(ple)-17.9(x f)-28(istul)-15.9(a-in-ano using )]TJ 0.226 Tw T* [(ind)-16(o)-16(cy)22(anine gr)-24(een fl)35.1(uor)-24(escence. )]TJ /T1_2 1 Tf (Colorectal Dis.)Tj /T1_1 1 Tf ( 2023;25\(6\):1300\226)Tj 0.023 Tw T* [(1301. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1111/codi.16499/)Tj 0 0 0 1 k /GS1 gs 0.014 Tc 0.518 Tw T* (16.)Tj /Span<>> BDC ( )Tj EMC 1.852 0 Td (\234\036\035\t\020\017\027)Tj /Span<>> BDC ( )Tj EMC (\236.\202., \200\026\f\017\035\034\036\r)Tj /Span<>> BDC ( )Tj EMC (\221.\200., \200\036\f\036\035\024\r)Tj /Span<>> BDC ( )Tj EMC (\202.\200., \017)Tj /Span<>> BDC ( )Tj EMC [(\f\024\026\r\021.)14( )]TJ 0.032 Tc 1.127 Tw -1.852 -1.25 Td [(\025)0.5(\035)0.5(\017\027)0.5(\017)0.5(\004)0.5(\036)0.5(\f\022)0.5(\017)0.5(\036)0.5( )0.5(\030\036)0.5(\022)0.5(\024)0.5(\n\036)0.5(\027)0.5(\007)0.5(\026\006)0.5(\017)0.5(\017)0.5(.)0.5( )0.5(\221)0.5(\r\017)0.5(\013)0.5( )0.5()0.5(\026)0.5(\007\027)0.5(\036)0.5(\020)0.5(\024 )0.6(\023\030)0.5(\024)0.5(\b)0.5(\024\007)0.5(\026)0.5(.)32( )]TJ /T1_2 1 Tf 0 Tc 0 Tw T* (\222\n\023\n\033\032\n\013\024\n\023\n\202\025\002.)Tj /T1_1 1 Tf 0.321 Tw [( 2020;19\(3\):10\22625. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.33878/2073-7556-)Tj T* (2020-19-3-10-25)Tj 0 0 0 1 k /GS1 gs 0.246 Tw T* (17.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (\025\024\f\021\026\030\036\r)Tj /Span<>> BDC ( )Tj EMC (\222.\200., \234\036\035\t\020\017\027)Tj /Span<>> BDC ( )Tj EMC (\236.\202., \230\017\021\024\r)Tj /Span<>> BDC ( )Tj EMC (\202.\236. \214\036\004\036\027\017\036 \f\r\017\013\036\005 )Tj 0.011 Tc 0.403 Tw -1.796 -1.25 Td [(\023\030\016\n\024\005 \022\017\001\022\017 \023\036\030\036\n\036\013\036\ \027\027\t\n \035\024\f\022\031\021\024\n: \031\f\021\026\030\036\r\001\017\ \005 \023\024\007\b\024\007)11( )]TJ 0 Tc 0.258 Tw T* (\017\035\017 \f\024\r\030\036\n\036\027\027\t\005 \n\036\021\024\007? \(\ \f\017\f\021\036\n\026\021\017\004\036\f\022\017\005 \024\002\024\030 \035\ \017\021\036\030\026\021\031\030\t\). )Tj /T1_2 1 Tf 0.007 Tc -0.007 Tw T* (\222\n\023\n\033\032\n\013\024\n\023\n\202\025\002.)Tj /T1_1 1 Tf 0.35 Tw [( 2016;55\(1\):6\22615. d)-16.3(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs -0.007 Tw (10.33878/2073-7556-)Tj 0 Tc 0 Tw T* (2016-0-1-6-15)Tj 0 0 0 1 k /GS1 gs 0.003 Tc 0.35 Tw T* (18.)Tj /Span<>> BDC ( )Tj EMC 1.809 0 Td (\204\026\021\017\027\016\027)Tj /Span<>> BDC ( )Tj EMC (\202.\200., \025\024\f\021\026\030\036\r)Tj /Span<>> BDC ( )Tj EMC (\222.\200., \207\035\026\020\024\007\026\030\027\t\005)Tj /Span<>> BDC ( )Tj EMC (\214.\202., \017)Tj /Span<>> BDC ( )Tj EMC [(\f\024\026\r\021.)3( )]TJ 0 Tc 0.007 Tw 27.246 23.75 Td (\214\036\004\036\027\017\036 \f\r\017\013\036\005 \023\030\016\n\024\005\ \022\017\001\022\017 \n\036\021\024\007\024\n \035\026\036\030\027\024\ \005 \021\036\030\n\024\024\002\035\017\021\036\030\026)Tj 0 Tw (-)Tj 0.071 Tw T* (\006\017\017 \f\r\017\013\036\r\024\020\024 \b\024\007\026 \(\f\017\f\021\ \036\n\026\021\017\004\036\f\022\017\005 \024\002\024\030\). )Tj /T1_2 1 Tf 0 Tw (\222\n\023\n\033\032\n\013\024\n\023\n\202\025\002. )Tj /T1_1 1 Tf 0.023 Tw T* [(2019;18\(3\):7\22619. d)-15.9(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.33878/2073-7556-2019-18-3-7-19)Tj 0 0 0 1 k /GS1 gs 0.015 Tc 0.545 Tw T* (19.)Tj /Span<>> BDC ( )Tj EMC 1.856 0 Td (\025\026\021\024\030\022\017\027)Tj /Span<>> BDC ( )Tj EMC (\221.\213., \240\031\030\026\r\035\036\r)Tj /Span<>> BDC ( )Tj EMC [(\202.\200., )0.5(\223\036\030\027\024\r)]TJ /Span<>> BDC ( )Tj EMC (\202.\202., \017)Tj /Span<>> BDC ( )Tj EMC 23.158 0 Td [(\f\024\026\r\021.)15.1( )]TJ 0.012 Tc 0.445 Tw -25.013 -1.25 Td [(\221\024\r\030\036\n\036\027\027\t\036 \f\235\017\027\022\021\036\030\024\ \f\024\b\030\026\027\016\033\013\017\036 \n\036\021\024\007\t \035\036\004\ \036\027\017\016 \004\030\036\f-)12( )]TJ 0 Tc 0.018 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC 0.768 0 Td [(\220\022\f\021\030\026\f\235\017\027\022\021\036\030\027\t\b )0.6(\023\026\030\026\030\036\022\021\026\035\034\027\t\b )0.7(\f\r\017\013\036\005. )]TJ /T1_2 1 Tf 0.017 Tw 19.026 0 Td (\217\n\027\n\t\024\025 \004\025\032\205\032\202\025\025. )Tj /T1_1 1 Tf 0 Tw -19.794 -1.25 Td (2018;26\(2\):204\226214.)Tj 0.35 Tw T* (20.)Tj /Span<>> BDC ( )Tj EMC 1.797 0 Td (\025\030\017\r\024\030\031\004\022\024)Tj /Span<>> BDC ( )Tj EMC (\222.\202., \205\017\030\f\017\022)Tj /Span<>> BDC ( )Tj EMC (\230.\203. \221\024\r\030\036\n\036\027\027\t\036 \n\026\035\024\017\027\ \r\026\017\r)Tj 0 Tw (-)Tj 0.012 Tc 0.456 Tw -1.797 -1.25 Td (\027\t\036 \f\235\017\027\022\021\036\030\024\f\002\036\030\036\020\026\033\ \013\017\036 \n\036\021\024\007\017\022\017 \b\017\030\031\030\020\017\004\ \036\f\022\024\020\024 \035\036\004\036)Tj 0 Tc 0 Tw (-)Tj 0.274 Tw T* (\027\017\016 \026\027\026\035\034\027\t\b \f\r\017\013\036\005. )Tj /T1_2 1 Tf (\217\n\027\n\t\024\025 \004\025\032\205\032\202\025\025.)Tj /T1_1 1 Tf ( 2020;28\(5\):565\226576. )Tj 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.18484/2305-0047.2020.5.565)Tj 0 0 0 1 k /GS1 gs 0.131 Tw -1.847 -1.25 Td (21.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (\025\024\f\021\026\030\036\r)Tj /Span<>> BDC ( )Tj EMC 4.145 0 Td [(\222.\200., )0.5(\205\024\n\036\027\022\024)]TJ /Span<>> BDC ( )Tj EMC 6.32 0 Td [(\210.\236., )0.5(\230\017\021\024\r)]TJ /Span<>> BDC ( )Tj EMC 5.193 0 Td [(\202.\236., )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 3.376 0 Td [(\f\024\026\r\021. )0.5(\025\035\017\027\017\022\024-)]TJ 0.027 Tw -20.83 -1.25 Td (\n\026\027\024\n\036\021\030\017\004\036\f\022\017\036 \017\n\036\027\036\ \027\017\016 \235\031\027\022\006\017\024\027\026\035\034\027\024\020\024\ \f\024\f\021\024\016\027\017\016 \026\023\017\030\026)Tj 0 Tw (-)Tj 0.113 Tw T* (\021\036\035\034\027\024\020\024 \026\023\023\026\030\026\021\026 \023\030\ \016\n\024\005 \022\017\001\022\017 \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r, \023\036\030\036\027\036\f\001\017\b\ \017\f\f\036)Tj 0 Tw (-)Tj 0.046 Tw T* (\004\036\027\017\036 \021\030\026\027\f- \017\035\017 \220\022\f\021\030\ \026\f\235\017\027\022\021\036\030\027\024\020\024 \f\r\017\013\026 \f)Tj /Span<>> BDC ( )Tj EMC (\031\001\017\r\026\027\017\036\n \f\235\017\027\022)Tj 0 Tw (-)Tj 0.01 Tc -0.01 Tw T* [(\021)0.5(\036\030\026)0.5(. )]TJ /T1_2 1 Tf 2.756 0 Td [(\222\n)0.5(\023)0.5(\n\033\032)0.5(\n\013)0.5(\024)0.5(\n\023)0.5(\n\202)0.5(\025\002)0.5(.)]TJ /T1_1 1 Tf 0.357 Tw [( 2)0.5(018)0.5(;\()0.5(4\))0.5(:3)0.5(1\226)0.5(38.)0.5( d)-15.6(o)0.5(i:)]TJ /Span<>> BDC 17.567 0 Td ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs -0.01 Tw [(10)0.5(.3)0.5(38)0.5(78/)0.5(20)0.5(73)0.5(-)]TJ 0 Tc 0 Tw -20.322 -1.25 Td (7556-2018-0-4-31-38)Tj 0 0 0 1 k /GS1 gs 0.004 Tc 0.35 Tw T* (22.)Tj /Span<>> BDC ( )Tj EMC 1.813 0 Td (\025\026\013\036\027\022\024)Tj /Span<>> BDC ( )Tj EMC (\200.\202., \214\024\007\t\020\017\027)Tj /Span<>> BDC ( )Tj EMC (\202.\200., \200\024\035\022\024\r\026)Tj /Span<>> BDC ( )Tj EMC (\213.\221., \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. ICG-)Tj 0.023 Tc 0.81 Tw -1.813 -1.25 Td [(\235)0.5(\035)0.6(\031)0.5(\024)0.5(\030)0.5(\036)0.5(\f)0.5(\006)0.6(\036)0.5(\027)0.5(\021)0.5(\027)0.6(\026)0.5(\016)0.5( \027)0.5(\026)0.5(\r)0.5(\017)0.5(\020)0.6(\026)0.5(\006)0.5(\017)0.5(\016)0.5( \r)]TJ /Span<>> BDC 14.246 0 Td ( )Tj EMC [(\022)0.5(\024)0.5(\035)0.5(\024)0.5(\030)0.5(\036)0.5(\022)0.6(\021)0.5(\026)0.5(\035)0.5(\034)0.6(\027)0.5(\024)0.5(\005)0.5( \b)0.5(\017)0.5(\030)0.5(\031)0.6(\030)0.5(\020)0.5(\017)0.5(\017)0.5(.)23( )]TJ /T1_2 1 Tf 0 Tc 0.023 Tw -14.246 -1.25 Td (\222\023\025\021\025\006\031\t\013\026\002 \005\n\023\022\021\025\203\026\ .)Tj /T1_1 1 Tf ( 2019;28\(2\):12\22617.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 42.5896 505.6259 Tm (REFERENCES)Tj 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0 Tc -0.022 Tw 8 0 0 8 42.5197 492.7912 Tm (1.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Z)-16(i)-24(t)-29.9(t)15(a)]TJ /Span<>> BDC ( )Tj EMC [(D.V., Subbo)17(t)-32(in)]TJ /Span<>> BDC ( )Tj EMC [(V.M. Appl)-31(ica)15(t)-31.9(ion of t)-12.9(he p)25(r)-32(o)-16(gr)-33(am for opt)-32(imiza)]TJ 0 Tw (-)Tj 0.059 Tw -1.296 -1.25 Td [(t)-32(ion of per)-37(ioper)-32.9(a)15(t)-32(i)-16(ve mana)-17(gement of p)32(a)15(t)-32(ients in elec)-16(t)-31.9(i)-16(ve col)30(or)-24(ec)-16(t)15(al )]TJ 0 Tw T* [(sur)-32(ger)-23.9(y. )]TJ /T1_2 1 Tf 3.557 0 Td [(K)18(olop)46(roktologia.)]TJ /T1_1 1 Tf 0.023 Tw ( 2013;1:15\22619. \(in Russ.\).)Tj 0.074 Tw -3.557 -1.25 Td (2.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(R)-24(ichar)-23.9(d)]TJ /Span<>> BDC ( )Tj EMC [(L, A)-13.9(bcar)-37(ian)]TJ /Span<>> BDC ( )Tj EMC [(H. Anal f)-28(istul)-15.9(a: p)25(r)-36.9(inc)-24(iples and mana)-17(gement. )]TJ /T1_2 1 Tf 0 Tw -1.296 -1.25 Td [(Sp)46(r)-37(ing)12(er)]TJ /T1_1 1 Tf 0.023 Tw (. 2014; 199 \030.)Tj 0.152 Tw T* (3.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Her)-32(old)]TJ /Span<>> BDC ( )Tj EMC 3.068 0 Td [(A, )0.5(L)35(ehur )0.6(P-A, )0.6(Ma)15(tzel)]TJ /Span<>> BDC ( )Tj EMC 8.719 0 Td [(KE, )0.6(e)-12(t)]TJ /Span<>> BDC ( )Tj EMC 2.786 0 Td [(al. )0.6(Col)30(op)25(r)-32(o)-16(c)-16(t)17(ol)30(o)-16(g)16(y, )0.6(Eur)-32(opean )]TJ 0.023 Tw -15.869 -1.25 Td [(manual of medic)-24(ine. )]TJ /T1_2 1 Tf 0 Tw [(Sp)46(r)-36.9(ing)12(er)]TJ /T1_1 1 Tf 0.023 Tw (. 2017; 465 \030.)Tj 0.318 Tw T* (4.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Bal)16(c)-24(iscue)-11.9(t)15(a)]TJ /Span<>> BDC ( )Tj EMC 5.165 0 Td [(Z, )0.5(U)15.1(r)-37(ibe)]TJ /Span<>> BDC ( )Tj EMC 3.907 0 Td [(N, )0.5(Bal)16.1(c)-24(iscue)-12(t)15(a)]TJ /Span<>> BDC ( )Tj EMC 6.49 0 Td [(I, )0.5(e)-12(t)]TJ /Span<>> BDC ( )Tj EMC 2.491 0 Td [(al. )0.6(R)12.9(ec)-15.9(t)15(al )0.5(ad)-17(v)-15(ance)]TJ 0 Tw (-)Tj 0.201 Tw -19.349 -1.25 Td [(ment fl)-15.9(ap for t)-13(he tr)-23.9(ea)15(tment of com)10(ple)-18(x cr)-24(ypt)17(o)-16(gl)-16(andul)-15.9(ar anal f)-28(is)]TJ 0 Tw (-)Tj 0.173 Tw T* [(tul)-16(as: a sy)-12.9(stema)15(t)-32(ic r)-24(ev)-16(iew and me)-12(t)15.1(a-anal)35(y)-13(sis. )]TJ /T1_2 1 Tf (Int J Colorectal Dis.)Tj /T1_1 1 Tf 0 Tw ( )Tj 0.023 Tw T* [(2017;32\(5\):599\226609. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1007/s00384-017-2779-7)Tj 0 0 0 1 k /GS1 gs -0.002 Tc 0.035 Tw T* (5.)Tj /Span<>> BDC ( )Tj EMC 1.29 0 Td [(Ama)15(t)17(o)]TJ /Span<>> BDC ( )Tj EMC [(A, Bo)17(t)-30(t)-32(ini)]TJ /Span<>> BDC ( )Tj EMC [(C, De Nar)-24(di)]TJ /Span<>> BDC ( )Tj EMC [(P, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Ev)-15(al)35(ua)15(t)-32(ion and mana)-17(gement)-2( )]TJ 0.077 Tw -1.29 -1.25 Td [(of per)-36.9(ianal abscess and anal f)-28(istul)-16(a: SICCR posi)-24(t)-32(ion st)15(a)15.1(tement. )]TJ /T1_2 1 Tf 0.002 Tw [(T)54(ech)-2( )]TJ T* [(Colop)46(roctol)]TJ /T1_1 1 Tf -0.014 Tw [(. 2020;24\(2\):127\226143. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0.002 Tw (10.1007/s10151-019-02144-1)Tj 0 0 0 1 k /GS1 gs 0 Tc 0.196 Tw T* (6.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (Emile)Tj /Span<>> BDC ( )Tj EMC (SH, Khan)Tj /Span<>> BDC ( )Tj EMC [(SM, A)15(dejumo)]TJ /Span<>> BDC ( )Tj EMC [(A, e)-11.9(t)]TJ /Span<>> BDC ( )Tj EMC [(al. L)-32(iga)15(t)-32(ion of inter)-9.9(sphinc)]TJ 0 Tw (-)Tj 0.181 Tw -1.296 -1.25 Td [(ter)-37(ic )0.5(f)-28(istul)-15.9(a )0.5(tr)-33(a)-17(c)-16(t )0.5(\(LIFT\) )0.5(in )0.5(tr)-24(ea)15(tment )0.5(of anal )0.5(f)-28(istul)-15.9(a: )0.5(An )0.5(upd)42(a)15(ted )]TJ 0.188 Tw T* [(sy)-13(stema)15.1(t)-32(ic )0.5(r)-24(ev)-15.9(iew, )0.5(me)-11.9(t)15(a-anal)35(y)-13(sis, )0.6(and )0.5(me)-12(t)15(a-r)-23.9(egr)-24(ession )0.6(of )0.5(t)-13(he )0.6(p)25(r)-24(e)]TJ 0 Tw (-)Tj 0.233 Tw T* [(dic)-16(t)17(or)-10(s )0.5(of )0.5(f)16(ail)35.1(ur)-24(e. )]TJ /T1_2 1 Tf 0 Tw 7.877 0 Td [(Surg)12(er)-43(y)]TJ /T1_1 1 Tf 0.233 Tw [(. )0.5(2020;167\(2\):484\226492. )0.6(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw 15.446 0 Td (10.1016/j.)Tj -23.324 -1.25 Td [(sur)-32(g.2019.09.012)]TJ 0 0 0 1 k /GS1 gs 0.22 Tw T* (7.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Elfek)-15.9(i)]TJ /Span<>> BDC ( )Tj EMC 2.718 0 Td [(H, )0.5(S)-15.9(hal)-16(ab)12(y)]TJ /Span<>> BDC ( )Tj EMC 4.833 0 Td [(M, )0.5(Emile)]TJ /Span<>> BDC ( )Tj EMC 3.966 0 Td [(SH, )0.5(e)-11.9(t)]TJ /Span<>> BDC ( )Tj EMC 2.995 0 Td [(al. )0.6(A )0.5(sy)-13(stema)15.1(t)-32(ic )0.5(r)-24(ev)-15.9(iew )0.5(and )]TJ 0.236 Tw -15.808 -1.25 Td [(me)-12(t)15(a-anal)35.1(y)-13(sis of t)-13(he safe)-11.9(t)-10(y and ef)-55.9(f)-28(ica)-17(cy of f)-28(istul)-16(a l)-16(aser cl)30(osur)-24(e. )]TJ /T1_2 1 Tf 0.31 Tw T* [(T)54(ech Colop)46(roctol)]TJ /T1_1 1 Tf [(. 2020;24\(4\):265\226274. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1007/s10151-020-)Tj T* (02165-1)Tj 0 0 0 1 k /GS1 gs 0.321 Tw T* (8.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(F)10(r)-32(ountzas)]TJ /Span<>> BDC ( )Tj EMC [(M, S)15(ter)-31.9(gios)]TJ /Span<>> BDC ( )Tj EMC [(K, Nikol)-16(aou)]TJ /Span<>> BDC ( )Tj EMC [(C, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Could F)-19(iL)-31.9(aC\250 be )]TJ 0.119 Tw -1.296 -1.25 Td [(ef)-56(fec)-16(t)-31.9(i)-16(ve in t)-12.9(he tr)-23.9(ea)15(tment of anal f)-28(istul)-16(as? A sy)-13(stema)15.1(t)-32(ic r)-24(ev)-16(iew of )]TJ 0.019 Tw T* [(obser)-32(v)-15(a)15(t)-31.9(ional studies and p)25(r)-32(opor)-22(t)-32(ional me)-12(t)15.1(a-anal)35(y)-13(sis. )]TJ /T1_2 1 Tf (Colorectal Dis)Tj /T1_1 1 Tf 0 Tw (. )Tj 0.023 Tw T* [(2020;22\(12\):1874\2261884. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1111/codi.15148)Tj 0 0 0 1 k /GS1 gs 0.033 Tw T* (9.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(G\366t)-30(tgens)]TJ /Span<>> BDC ( )Tj EMC [(KW, Smee)-11.9(ts)]TJ /Span<>> BDC ( )Tj EMC [(RR, )0.5(S)15(t)15(assen)]TJ /Span<>> BDC ( )Tj EMC [(LP, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Sy)-13(stema)15.1(t)-32(ic r)-24(ev)-16(iew and )]TJ 0.314 Tw -1.296 -1.25 Td [(me)-12(t)15(a-anal)35.1(y)-13(sis of sur)-32(gical inter)-31.9(vent)-32(ions for high cr)-23.9(ypt)17(o)-16(gl)-16(andul)-15.9(ar )]TJ -0.022 Tw T* [(per)-37(ianal f)-28(istul)-15.9(a. )]TJ /T1_2 1 Tf (Int J Colorectal Dis. )Tj /T1_1 1 Tf [(2015;30:583\226593. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1007/)Tj T* (s00384-014-2091-8)Tj 0 0 0 1 k /GS1 gs 0.278 Tw T* (10.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Al)-16(ander)]TJ /Span<>> BDC ( )Tj EMC 3.603 0 Td [(JT, )0.5(K)-15.9(aar)-22(t)-32(inen)]TJ /Span<>> BDC ( )Tj EMC 6.083 0 Td [(I, )0.5(L)-31.9(aak)-10(so)]TJ /Span<>> BDC ( )Tj EMC 4.328 0 Td [(A, )0.5(e)-12(t)]TJ /Span<>> BDC ( )Tj EMC 2.591 0 Td [(al. )0.5(A )0.6(r)-24(ev)-16(iew )0.6(of )0.5(ind)-16(o)]TJ 0 Tw (-)Tj 0.017 Tw -18.401 -1.25 Td [(cy)22(anine gr)-24(een fl)35(uor)-23.9(escent ima)-17(ging in sur)-32(ger)-24(y. )]TJ /T1_2 1 Tf (Int J Biomed Imaging)Tj /T1_1 1 Tf 0 Tw (. )Tj 0.023 Tw T* [(2012;2012:940585. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1155/2012/940585)Tj 0 0 0 1 k /GS1 gs 0.038 Tw T* (11.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Boni)Tj /Span<>> BDC ( )Tj EMC [(L, Dav)-16(id)]TJ /Span<>> BDC ( )Tj EMC (G, Mangano)Tj /Span<>> BDC ( )Tj EMC [(A, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. A. f)-28(inger hut cl)-31(inical appl)-31(ica)]TJ 0 Tw (-)Tj 0.113 Tw -1.796 -1.25 Td [(t)-32(ions of ind)-16(o)-16(cy)22(anine gr)-23.9(een \(ICG\) enhanced fl)35(uor)-24(escence in l)-16(ap)32(ar)-32(o)]TJ 0 Tw (-)Tj 0.053 Tw T* [(scopic sur)-32(ger)-24(y. )]TJ /T1_2 1 Tf (Surg. Endosc. )Tj /T1_1 1 Tf [(2015;29\(7\):2046\2262055. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1007/)Tj T* (s00464-014-3895-x)Tj 0 0 0 1 k /GS1 gs 0.081 Tw T* [(1)72(2)35(.)]TJ /Span<>> BDC ( )Tj EMC 1.689 0 Td [(R)13(einhar)-22(t)]TJ /Span<>> BDC ( )Tj EMC [(MB, Hunt)-32(ing)17(t)17(on)]TJ /Span<>> BDC ( )Tj EMC [(CR, Bl)-16(air)]TJ /Span<>> BDC ( )Tj EMC [(LJ, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Ind)-16(o)-16(cy)22(anine gr)-24(een: )]TJ 0.15 Tw -1.689 -1.25 Td [(hist)17(or)-36.9(ical conte)-17.9(xt)72(, cur)-23.9(r)-24(ent )0.5(appl)-31(ica)15(t)-32(ions)48(, )0.5(and )0.5(futur)-24(e )0.5(consider)-33(a)15(t)-32(ions)16(. )]TJ /T1_2 1 Tf 0.023 Tw 29.055 48.75 Td [(Surg Innov)16(at)]TJ /T1_1 1 Tf [(. 2)20(0)72(1)40(6;2)40(3\(2\):1)40(66\2261)95(7)49.9(5)25.1(. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw [(1)45(0)15(.)45(1)136(1)95(7)72(7)104(/)72(1)40(5)19.9(5)30(3)40(3)35(5)20(06)101(1)40(5)15(604)25(05)30(3)]TJ 0 0 0 1 k /GS1 gs 0.062 Tw T* (13.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Gupt)15(a)]TJ /Span<>> BDC ( )Tj EMC [(P, Misr)-33(a)]TJ /Span<>> BDC ( )Tj EMC [(S, K)25(umar)]TJ /Span<>> BDC ( )Tj EMC [(S)17(S, e)-11.9(t)]TJ /Span<>> BDC ( )Tj EMC [(al. R)13(elev)-15(ance of poster)-36.9(ior gastr)-37(ic )]TJ 0.002 Tc 0.349 Tw -1.796 -1.25 Td [(v)0.5(e)0.6(s)0.5(s)0.5(e)0.5(l)0.6( i)0.5(n)0.6( b)0.5(a)0.5(r)-36.4(i)0.5(a)15.5(t)0.6(r)-36.5(i)0.5(c)0.6( s)0.5(u)0.6(r)-31.5(g)0.5(e)0.5(r)-23.4(y)0.5(.)0.5( )]TJ /T1_2 1 Tf [(O)0.5(b)0.5(e)0.6(s)0.5( S)0.6(u)0.5(r)0.5(g)0.5(.)]TJ /T1_1 1 Tf 16.824 0 Td [( 2)0.6(0)0.5(2)0.5(0)0.5(;)0.6(3)0.5(0)0.5(\()0.5(1)0.5(2)0.5(\))0.6(:)0.5(5)0.5(1)0.5(6)0.6(7)0.5(\226)0.5(5)0.5(1)0.5(6)0.5(9)0.6(.)2( )]TJ 0 Tc 0 Tw -16.824 -1.25 Td [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1007/s11695-020-04949-8)Tj 0 0 0 1 k /GS1 gs 0.074 Tw -1.847 -1.25 Td (14.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Jo)-16(osten)]TJ /Span<>> BDC ( )Tj EMC [(JJ, S)-16(l)30(o)-16(o)17(ter)]TJ /Span<>> BDC ( )Tj EMC [(MD, v)-15(an den El)-39.9(zen)]TJ /Span<>> BDC ( )Tj EMC [(RM, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. U)13(nder)-10(st)15(anding )]TJ 0.112 Tw -1.796 -1.25 Td [(fl)35(uor)-23.9(escence t)-32(ime cur)-32(ves dur)-37(ing ileal pouch-anal anast)17.1(omosis wi)-23.9(t)-13(h )]TJ 0.163 Tw T* [(or )0.5(wi)-24(t)-13(hout )0.5(v)-15(ascul)-15.9(ar )0.5(l)-31(iga)15(t)-32(ion. )]TJ /T1_2 1 Tf 12.398 0 Td [(Surg )0.5(Endosc.)]TJ /T1_1 1 Tf [( )0.5(2023;37\(7\):5086\2265093. )]TJ 0 Tw -12.398 -1.25 Td [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1007/s00464-023-09921-y)Tj 0 0 0 1 k /GS1 gs 0.232 Tw -1.847 -1.25 Td (15.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(P)35(r)-37(imo-R)11.1(oma)-17(guer)-33(a)]TJ /Span<>> BDC ( )Tj EMC [(V, L)35(opez)]TJ /Span<>> BDC ( )Tj EMC [(DP, Al)30(v)-14.9(ar)-24(ez-Sar)-24(r)-32.9(ad)-16(o)]TJ /Span<>> BDC ( )Tj EMC [(E, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. F)10(ull-)]TJ 0.095 Tw -1.796 -1.25 Td [(t)-13(hickness r)-23.9(ec)-16(t)15(al ad)-17(v)-14.9(ancement fl)-16(ap for com)10(ple)-17.9(x f)-28(istul)-15.9(a-in-ano using )]TJ 0.226 Tw T* [(ind)-16(o)-16(cy)22(anine gr)-24(een fl)35.1(uor)-24(escence. )]TJ /T1_2 1 Tf (Colorectal Dis.)Tj /T1_1 1 Tf ( 2023;25\(6\):1300\226)Tj 0.023 Tw T* [(1301. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1111/codi.16499/)Tj 0 0 0 1 k /GS1 gs 0.158 Tw T* (16.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(S)-16(hel)35(ygin)]TJ /Span<>> BDC ( )Tj EMC [(Y.A., V)25(asil)-31(iev)]TJ /Span<>> BDC ( )Tj EMC [(S.V., V)30(esel)30(ov)]TJ /Span<>> BDC ( )Tj EMC [(A.V., e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Cl)-30.9(inical guide)]TJ 0 Tw (-)Tj 0.198 Tw -1.796 -1.25 Td [(l)-31(ines: )0.6(F)-19(istul)-15.9(a )0.5(of )0.6(t)-13(he )0.5(anus. )]TJ /T1_2 1 Tf 0 Tw 11.464 0 Td [(K)18(olop)46(roktologia.)]TJ /T1_1 1 Tf 0.198 Tw [( )0.6(2020;19\(3\):10\22625. )0.6(\(in )]TJ 0.023 Tw -11.464 -1.25 Td [(Russ.\). d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.33878/2073-7556-2020-19-3-10-25)Tj 0 0 0 1 k /GS1 gs -0.016 Tw T* (17.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(K)25(ost)15(ar)-24(ev)]TJ /Span<>> BDC ( )Tj EMC [(I.V., S)-16(hel)35(ygin)]TJ /Span<>> BDC ( )Tj EMC [(Y.A., T)34.9(i)-23.9(t)17(ov)]TJ /Span<>> BDC ( )Tj EMC [(A.Y)35(u. T)50(r)-24(ea)15(tment of r)-24(ec)-16(t)15(al f)-28(istu)]TJ 0 Tw (-)Tj -0.013 Tw -1.796 -1.25 Td [(l)-16(as wi)-24(t)-13(h a displ)-16(a)-17(ced fl)-15.9(ap: an outd)42.1(a)15(ted app)25(r)-32(oa)-17(ch or a moder)-15(n me)-12(t)-13(hod? )]TJ 0.294 Tw T* [(\(sy)-13(stema)15.1(t)-32(ic l)-31(i)-24(ter)-32.9(a)15(tur)-24(e r)-24(ev)-16(iew\). )]TJ /T1_2 1 Tf 0 Tw [(K)18(olop)46(roktologia.)]TJ /T1_1 1 Tf 0.294 Tw ( 2016;55\(1\):6\22615. )Tj 0.023 Tw T* [(\(in Russ.\). d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.33878/2073-7556-2016-0-1-6-15)Tj 0 0 0 1 k /GS1 gs 0.143 Tw T* (18.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Ma)15(t)-32(iny)22(an)]TJ /Span<>> BDC ( )Tj EMC [(A.V., K)25(ost)15.1(ar)-24(ev)]TJ /Span<>> BDC ( )Tj EMC [(I.V., Bl)-16(a)-17(god)42(ar)-14.9(ny)]TJ /Span<>> BDC ( )Tj EMC [(L.A., e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. T)50(r)-24(ea)15(tment )]TJ 0.066 Tw -1.796 -1.25 Td [(of r)-24(ec)-16(t)15(al f)-28(istul)-15.9(as wi)-24(t)-12.9(h l)-16(aser t)-12.9(her)-16(mal obl)-31(i)-24(ter)-33(a)15(t)-31.9(ion of t)-13(he f)-28(istul)-16(a tr)-33(a)-17(c)-16(t )]TJ 0.175 Tw T* [(\(sy)-13(stema)15.1(t)-32(ic r)-24(ev)-16(iew\). )]TJ /T1_2 1 Tf 0 Tw [(K)18(olop)46(roktologia.)]TJ /T1_1 1 Tf 0.175 Tw ( 2019;18\(3\):7\22619. \(in Russ.\). )Tj 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.33878/2073-7556-2019-18-3-7-19)Tj 0 0 0 1 k /GS1 gs -0.013 Tw -1.847 -1.25 Td (19.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(K)-16(a)15(t)17(or)-23.9(k)-16(in)]TJ /Span<>> BDC ( )Tj EMC [(S.E., Zhur)-32.9(avlev)]TJ /Span<>> BDC ( )Tj EMC [(A.V., Cher)-15(nov)]TJ /Span<>> BDC ( )Tj EMC [(A.A., e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. M)-24(oder)-15(n sphinc)]TJ 0 Tw (-)Tj 0.014 Tw -1.796 -1.25 Td [(ter sav)-16(ing me)-12(t)-13(hods of tr)-23.9(ea)15(tment of tr)-32.9(ansphinc)-16(ter)-36.9(ic and e)-18(xtr)-33(asphinc)]TJ 0 Tw (-)Tj 0.221 Tw T* [(ter)-37(ic per)-36.9(ianal f)-28(istul)-15.9(as. )]TJ /T1_2 1 Tf [(N)17(ov)13(osti Khirurgii.)]TJ /T1_1 1 Tf ( 2018;26\(2\):204\226214. \(in )Tj 0 Tw T* (Russ.\).)Tj 0.032 Tw T* (20.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Kr)-24(yvor)-21.9(uchko)]TJ /Span<>> BDC ( )Tj EMC [(I.A., F)-19(ir)-10(syk)]TJ /Span<>> BDC ( )Tj EMC [(T.M. M)-24(oder)-15(n minimall)35.1(y inv)-15(asi)-16(ve sphinc)]TJ 0 Tw (-)Tj 0.021 Tw -1.796 -1.25 Td [(ter-sp)32(ar)-36.9(ing techniques of sur)-32(gical tr)-24(ea)15(tment of anal f)-28(istul)-16(as. )]TJ /T1_2 1 Tf 0 Tw [(N)17(ov)13(osti )]TJ 0.004 Tc -0.004 Tw T* [(K)0.5(h)0.5(i)0.5(r)0.5(u)0.5(r)0.5(g)0.5(i)0.5(i)]TJ /T1_1 1 Tf 0.349 Tw 3.413 0 Td [(.)0.5( 2)0.5(0)0.5(2)0.5(0)0.5(;)0.5(2)0.5(8)0.5(\()0.5(5)0.5(\))0.5(:)0.5(5)0.5(6)0.5(5)0.5(\226)0.5(5)0.5(7)0.5(6)0.5(.)0.5( \()0.5(i)0.5(n)0.5( R)0.5(u)0.5(s)0.5(s)0.5(.)0.5(\))0.5(.)0.5( d)-15.5(o)0.5(i)0.5(:)]TJ /Span<>> BDC 17.002 0 Td ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs -0.004 Tw [(1)0.5(0)0.5(.)0.5(1)0.5(8)0.5(4)0.5(8)0.5(4)0.5(/)0.5(2)0.5(3)0.5(0)0.5(5)0.5(-)]TJ 0 Tc 0 Tw -20.415 -1.25 Td (0047.2020.5.565)Tj 0 0 0 1 k /GS1 gs 0.241 Tw T* (21.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(K)25(ost)15(ar)-24(ev)]TJ /Span<>> BDC ( )Tj EMC [(I.V., F)10(omenko)]TJ /Span<>> BDC ( )Tj EMC [(O.Y)35(u., T)35(i)-24(t)17(ov)]TJ /Span<>> BDC ( )Tj EMC [(A.Y)35.1(u., e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Cl)-31(inical and )]TJ 0.005 Tw -1.796 -1.25 Td [(manome)-12(tr)-36.9(ic changes in t)-13(he func)-15.9(t)-32(ional st)15(a)15(te of t)-13(he ob)16(tur)-33(a)15(t)17(or app)32(ar)-33(a)]TJ 0 Tw (-)Tj 0.05 Tw T* [(tus of t)-13(he r)-24(ec)-15.9(tum in p)32(a)15(t)-31.9(ients who under)-37.9(went e)-18(x)-13(c)-23.9(ision of a tr)-33(ans- or )]TJ 0.287 Tw T* [(e)-18(xtr)-32.9(asphinc)-16(ter)-37(ic f)-28(istul)-16(a wi)-24(t)-13(h sphinc)-16(ter sutur)-37(ing. )]TJ /T1_2 1 Tf 0 Tw [(K)18(olop)46(roktologia)]TJ /T1_1 1 Tf (. )Tj 0.001 Tc 0.35 Tw T* [(2018;\(4\):31\22638. )0.5(\(in Russ.\). )0.5(d)-16.1(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs -0.001 Tw 14.609 0 Td (10.33878/2073-7556-2018-0-4-)Tj 0 Tc 0 Tw -14.609 -1.25 Td (31-38)Tj 0 0 0 1 k /GS1 gs -0.068 Tw T* (22.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(K)-16(ashchenko)]TJ /Span<>> BDC ( )Tj EMC [(V.A., L)35(od)17(ygin)]TJ /Span<>> BDC ( )Tj EMC [(A.V., V)29(olkov)-15(a)]TJ /Span<>> BDC ( )Tj EMC [(E.S., e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. ICG-fl)35.1(uor)-24(escent )]TJ 0.173 Tw -1.796 -1.25 Td [(nav)-16(iga)15(t)-31.9(ion in col)30.1(or)-24(ec)-16(t)15(al sur)-32(ger)-24(y. )]TJ /T1_2 1 Tf (Clinical Hospital. )Tj /T1_1 1 Tf 0 Tw (2019;28\(2\):12\226)Tj 0.023 Tw T* (17. \(in Russ.\).)Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 0 Tw 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\033\030\031\030\213\b)-20.9(\035\231\213\233\t \021\032)50(\b)42(\032\231\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj /T1_4 1 Tf 25 0 0 25 512.8518 56.0378 Tm (99)Tj ET endstream endobj 1505 0 obj <>/Border[0 0 0]/H/N/Rect[57.2978 728.512 154.769 719.216]/Subtype/Link/Type/Annot>> endobj 1506 0 obj <>/Border[0 0 0]/H/N/Rect[57.2978 688.512 154.329 679.216]/Subtype/Link/Type/Annot>> endobj 1507 0 obj <>/Border[0 0 0]/H/N/Rect[77.716 648.512 147.268 639.216]/Subtype/Link/Type/Annot>> endobj 1508 0 obj <>/Border[0 0 0]/H/N/Rect[192.078 618.512 263.622 609.056]/Subtype/Link/Type/Annot>> endobj 1509 0 obj <>/Border[0 0 0]/H/N/Rect[42.5197 608.512 97.7834 599.216]/Subtype/Link/Type/Annot>> endobj 1510 0 obj <>/Border[0 0 0]/H/N/Rect[191.028 568.512 263.622 559.056]/Subtype/Link/Type/Annot>> endobj 1511 0 obj <>/Border[0 0 0]/H/N/Rect[42.5197 558.512 89.7834 549.216]/Subtype/Link/Type/Annot>> endobj 1512 0 obj <>/Border[0 0 0]/H/N/Rect[349.381 718.512 472.188 709.216]/Subtype/Link/Type/Annot>> endobj 1513 0 obj <>/Border[0 0 0]/H/N/Rect[289.739 638.512 397.57 629.216]/Subtype/Link/Type/Annot>> endobj 1514 0 obj <>/Border[0 0 0]/H/N/Rect[442.342 588.512 496.063 579.056]/Subtype/Link/Type/Annot>> endobj 1515 0 obj <>/Border[0 0 0]/H/N/Rect[274.961 578.512 345.04 569.216]/Subtype/Link/Type/Annot>> endobj 1516 0 obj <>/Border[0 0 0]/H/N/Rect[128.94 400.087 222.411 390.791]/Subtype/Link/Type/Annot>> endobj 1517 0 obj <>/Border[0 0 0]/H/N/Rect[166.55 370.087 263.622 360.631]/Subtype/Link/Type/Annot>> endobj 1518 0 obj <>/Border[0 0 0]/H/N/Rect[229.11 330.087 263.622 320.631]/Subtype/Link/Type/Annot>> endobj 1519 0 obj <>/Border[0 0 0]/H/N/Rect[42.5197 320.087 99.6552 310.791]/Subtype/Link/Type/Annot>> endobj 1520 0 obj <>/Border[0 0 0]/H/N/Rect[192.966 290.087 263.622 280.631]/Subtype/Link/Type/Annot>> endobj 1521 0 obj <>/Border[0 0 0]/H/N/Rect[42.5197 280.087 69.3356 270.791]/Subtype/Link/Type/Annot>> endobj 1522 0 obj <>/Border[0 0 0]/H/N/Rect[140.94 240.087 206.947 230.791]/Subtype/Link/Type/Annot>> endobj 1523 0 obj <>/Border[0 0 0]/H/N/Rect[233.71 210.087 263.622 200.631]/Subtype/Link/Type/Annot>> endobj 1524 0 obj <>/Border[0 0 0]/H/N/Rect[42.5197 200.087 106.079 190.791]/Subtype/Link/Type/Annot>> endobj 1525 0 obj <>/Border[0 0 0]/H/N/Rect[122.572 170.087 196.028 160.791]/Subtype/Link/Type/Annot>> endobj 1526 0 obj <>/Border[0 0 0]/H/N/Rect[233.71 140.087 263.622 130.631]/Subtype/Link/Type/Annot>> endobj 1527 0 obj <>/Border[0 0 0]/H/N/Rect[42.5197 130.087 105.631 120.791]/Subtype/Link/Type/Annot>> endobj 1528 0 obj <>/Border[0 0 0]/H/N/Rect[402.969 500.087 489.042 490.631]/Subtype/Link/Type/Annot>> endobj 1529 0 obj <>/Border[0 0 0]/H/N/Rect[289.739 470.087 387.21 460.791]/Subtype/Link/Type/Annot>> endobj 1530 0 obj <>/Border[0 0 0]/H/N/Rect[289.739 430.087 386.77 420.791]/Subtype/Link/Type/Annot>> endobj 1531 0 obj <>/Border[0 0 0]/H/N/Rect[310.157 390.087 379.709 380.791]/Subtype/Link/Type/Annot>> endobj 1532 0 obj <>/Border[0 0 0]/H/N/Rect[314.069 360.087 440.876 350.791]/Subtype/Link/Type/Annot>> endobj 1533 0 obj <>/Border[0 0 0]/H/N/Rect[325.463 320.087 444.27 310.791]/Subtype/Link/Type/Annot>> endobj 1534 0 obj <>/Border[0 0 0]/H/N/Rect[289.739 280.087 412.546 270.791]/Subtype/Link/Type/Annot>> endobj 1535 0 obj <>/Border[0 0 0]/H/N/Rect[442.971 210.087 496.063 200.631]/Subtype/Link/Type/Annot>> endobj 1536 0 obj <>/Border[0 0 0]/H/N/Rect[274.961 200.087 330.064 190.791]/Subtype/Link/Type/Annot>> endobj 1537 0 obj <>/Border[0 0 0]/H/N/Rect[391.833 150.087 496.063 140.791]/Subtype/Link/Type/Annot>> endobj 1538 0 obj <>/Border[0 0 0]/H/N/Rect[274.961 140.087 293.777 130.791]/Subtype/Link/Type/Annot>> endobj 1572 0 obj <> endobj 1571 0 obj <> endobj 1570 0 obj <> endobj 1569 0 obj <> endobj 1568 0 obj <> endobj 1567 0 obj <> endobj 1566 0 obj <> endobj 1565 0 obj <> endobj 1564 0 obj <> endobj 1563 0 obj <> endobj 1562 0 obj <> endobj 1561 0 obj <> endobj 1560 0 obj <> endobj 1559 0 obj <> endobj 1558 0 obj <> endobj 1557 0 obj <> endobj 1556 0 obj <> endobj 1555 0 obj <> endobj 1554 0 obj <> endobj 1553 0 obj <> endobj 1552 0 obj <> endobj 1551 0 obj <> endobj 1550 0 obj <> endobj 1549 0 obj <> endobj 1548 0 obj <> endobj 1547 0 obj <> endobj 1546 0 obj <> endobj 1545 0 obj <> endobj 1544 0 obj <> endobj 1543 0 obj <> endobj 1542 0 obj <> endobj 1541 0 obj <> endobj 1540 0 obj <> endobj 1539 0 obj <> endobj 1495 0 obj [1573 0 R 1574 0 R 1575 0 R 1576 0 R 1577 0 R 1578 0 R 1579 0 R 1580 0 R 1581 0 R 1582 0 R 1583 0 R 1584 0 R 1585 0 R] endobj 1496 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.023 Tw 10 0 0 10 70.8661 724.8299 Tm (\223\030\032\255\020\034\036 \032\026\020\017\022\017\026)Tj /T1_1 1 Tf 0.227 Tw 0 -1.218 TD [(\025)-4.1(\024)-4.3(\027)1.7(\006)-6(\036)-6.8(\023)2.2(\006)-6(\017)-5.4(\016 \017)]TJ /Span<>> BDC ( )Tj EMC [(\007)-6(\017)2.7()-9.9(\026\005)1.7(\027 \017)-2.4(\f)3.1(\f)-38.9(\035)-6.8(\036)-19(\007)-4.4(\024)-4.3(\r)-8.9(\026\027)1.7(\017)-5.4(\016)13.7(:)]TJ /T1_2 1 Tf -0.008 Tc 0.235 Tw [( \206)8.6(\025\024)-1.1(\026)-6.2(\032\022)-13.7(\002)2.2(\021)]TJ /Span<>> BDC 20.017 0 Td ( )Tj EMC [(\201)-10.3(.)21.3(\210)114(.,)-8( )]TJ 0.002 Tc -0.002 Tw -20.017 -1.218 Td [(\201)17.5(\030)7.4(\025)5.5(\016)4.2(\n)11.6(\027)]TJ /Span<>> BDC 2.849 0 Td ( )Tj EMC [(\207.)9.3(\201.)]TJ /T1_1 1 Tf 0 Tc 0.766 Tw -2.849 -1.218 Td [(\221)-4.6(\002)-9.9(\024)0.7(\030 \017)]TJ /Span<>> BDC ( )Tj EMC [(\024)-11.8(\002)3(\030)-11.4(\026)-6.3(\002)-9.9(\024)-10.9(\021)-17.7(\022)-19.1(\026 \n)1.3(\026)-11.8(\021)-9.9(\036)-1.6(\030)-7.6(\017)-0.6(\026)-33.1(\035\026)3.7(:)]TJ /T1_2 1 Tf -0.029 Tc 0.795 Tw [( \222)-12.4(\025)-25.7(\t)-54.1(\023)-15.8(\002)-18.3(\013)-19.2(\n)-19.4(\027)]TJ /Span<>> BDC 19.293 0 Td ( )Tj EMC [(\216)-4.7(.\217.)-21.2(,)-29( )]TJ 0 Tc 0 Tw -19.293 -1.218 Td [(\255)0.5(\032\031)-26(\004)4.7(\n)9.6(\027)]TJ /Span<>> BDC ( )Tj EMC [(\201)-2.2(.)7.3(\201)-2.3(.)7.8(, \255\033)5.9(\023)9.6(\025)4.6(\003)7(\026)-14.4(\004)]TJ /Span<>> BDC ( )Tj EMC [(\222)8.6(.)43.7(\207)-2.1(.)7.8(, \210)101.4(\n)10.1(\023)3.4(\n)9.6(\027)5.5(\025)7.2(\021)9.5(\026)]TJ /Span<>> BDC ( )Tj EMC [(\201)-2.3(.)7.3(\201)-2.3(.)]TJ /T1_1 1 Tf 0.346 Tw T* [(\221)17.2(\021)-21.5(\026)-11.8(\021)-17.7(\017)-2.4(\f)-36(\021)-17.7(\017)4.6(\004)-8.2(\036)-10.4(\f)-1.6(\022)-19.1(\026)-21.1(\016 \024)-11.8(\002)3(\030)-11.4(\026)-6.3(\002)-9.9(\024)-10.9(\021)-17.7(\022)-19.1(\026 \007)-20.1(\026\027)1.8(\027)1.7(\t)-12.8(\b)-9.4(:)]TJ /T1_2 1 Tf -0.01 Tc 0.356 Tw [( \201)-27.3(\023\025)-8.3(\005)-9.9(\031)-7.2(\013\n\027)]TJ /Span<>> BDC 19.777 0 Td ( )Tj EMC [(\201)-12.3(.)-6.2(\221)17.6(.)-2.2(,)-10( )]TJ -0.007 Tc 0.007 Tw -19.777 -1.218 Td [(\206)9.6(\025)0.7(\024\026)-5.2(\032)0.5(\022)-12.7(\002)3.2(\021)]TJ /Span<>> BDC 4.009 0 Td ( )Tj EMC [(\216)17.3(.\201)-9.3(.)]TJ /T1_1 1 Tf 0.002 Tc -0.002 Tw -4.009 -1.218 Td [(\203)7.2(\026\023)4.2(\017\f)-10.8(\026)1.7(\027)3.7(\017)-6.7(\036)2.1( \021)-7.9(\036)-3.4(\022\f)-34(\021)-19.5(\026)5.7(:)]TJ /T1_2 1 Tf 7.694 0 Td [( \201)17.5(\030)7.4(\025)5.5(\016)4.2(\n)11.6(\027)]TJ /Span<>> BDC 3.082 0 Td ( )Tj EMC [(\207.)9.3(\201.)9.8(,)2( \210)103.5(\n)12.1(\023)5.3(\n)11.6(\027)7.5(\025)9.2(\021)11.5(\026)]TJ /Span<>> BDC 5.924 0 Td ( )Tj EMC [(\201.)9.3(\201.)]TJ /T1_1 1 Tf 0 Tc 0 Tw -16.699 -1.218 Td [(\217)5.5(\036)-19(\007)-20.1(\026\022)-32.6(\021)-17.7(\017)1.5(\030)-11.8(\024)-4.4(\r)-8.8(\026\027)1.8(\017)-8.7(\036)6.5(:)]TJ /T1_2 1 Tf -0.007 Tc 0.007 Tw [( \206)9.6(\025)0.7(\024\026)-5.2(\032)0.5(\022)-12.7(\002)3.2(\021)]TJ /Span<>> BDC 11.376 0 Td ( )Tj EMC [(\201)-9.3(.)22.3(\210)115(.)0.8(,)-7( \210)94.4(\n)3.2(\023)-3.7(\n)2.6(\027)-1.5(\025\021)2.5(\026)]TJ /Span<>> BDC 5.798 0 Td ( )Tj EMC [(\201)-9.3(.\201)-9.3(.)]TJ /T1_0 1 Tf 0 Tc 0.023 Tw -17.175 -2.436 Td (AUTHORS CONTRIBUTION)Tj /T1_1 1 Tf -0.075 Tw T* [(C)-6.5(o)0.8(nce)-0.7(p)-12.3(t a)2.4(n)-4.6(d d)-5.5(e)-13.3(s)-16.6(i)3.2(g)1.2(n o)-2.2(f t)-16.7(h)-5.3(e s)-20(t)-12.7(ud)-10.9(y)-11.8(:)]TJ /T1_2 1 Tf [( A)3.6(l)4.8(ek)-17.5(s)7.8(a)-0.8(n)-0.6(d)5.3(r)]TJ /Span<>> BDC ( )Tj EMC [(G)-1.4(.)]TJ /Span<>> BDC ( )Tj EMC [(K)0.7(h)6.2(i)0.9(t)2.3(ar)-40.1(y)3.8(a)-0.8(n)-6(, )]TJ 0.001 Tc -0.001 Tw 0 -1.218 TD [(S)16.8(u)3.8(l)5.8(e)-0.9(i)9.4(m)5.3(an)]TJ /Span<>> BDC 3.591 0 Td ( )Tj EMC [(A)-11.6(.)]TJ /Span<>> BDC 1.08 0 Td ( )Tj EMC [(Ad)2.4(i)13.5(z)13.4(ov)]TJ /T1_1 1 Tf 0 Tc 1.275 Tw -4.67 -1.218 Td [(C)-6.5(o)-5.8(l)-19(l)-14.3(e)-9.4(c)-32.5(t)-37.3(i)3.2(o)0.8(n a)2.5(n)-4.6(d p)-3.8(r)-5.9(o)-7(ce)-13.3(s)-12.8(s)-16.6(i)7.1(n)-1.9(g o)-2.2(f t)-16.7(h)-5.3(e m)1.8(a)-8.4(t)-15.2(e)]TJ 0 Tw 21.758 0 Td (-)Tj -0.005 Tc 0.005 Tw -21.758 -1.218 Td [(r)-53(ia)-6.5(l)-27.5(:)]TJ /T1_2 1 Tf 0 Tc 0.806 Tw 1.679 0 Td [( V)25.9(a)-2.9(s)-8.4(i)7.5(l)4.3(iy)]TJ /Span<>> BDC ( )Tj EMC [(N)13(.)]TJ /Span<>> BDC ( )Tj EMC [(K)10.8(i)11.1(s)9.3(l)11(y)3.8(a)1.7(k)12.9(o)-0.6(v)33.6(, A)3.7(l)4.8(ek)-17.5(s)4.9(e)-2.5(y)]TJ /Span<>> BDC ( )Tj EMC [(A)-12.6(.)]TJ /Span<>> BDC ( )Tj EMC [(O)-4.1(r)2.4(ek)5.3(h)1.9(o)-0.6(v)33.6(, )]TJ 0 Tw -1.679 -1.218 Td [(K)-21.9(s)4.9(e)-2.6(n)6.2(iy)3.8(a)]TJ /Span<>> BDC ( )Tj EMC [(S)2.2(.)]TJ /Span<>> BDC ( )Tj EMC [(O)-8.1(p)-0.6(l)4.3(i)8.4(m)4.3(a)1.7(k)5.4(h)-6(, A)3.8(n)4.8(a)-3(s)-10.7(t)2.3(a)-3(s)-8.3(iy)3.8(a)]TJ /Span<>> BDC ( )Tj EMC [(\201)-2.3(.)]TJ /Span<>> BDC ( )Tj EMC [(G)-1.4(o)-1.1(l)2.9(ov)-28.6(i)8.4(n)4.8(a)]TJ /T1_1 1 Tf -0.007 Tc 1.436 Tw 0 -1.218 TD [(St)-34.7(a)-15.4(t)-44.4(i)-4.3(s)-27(t)-44.4(i)-1.8(c)-18.8(a)-8.5(l)-7( )0.5(p)-10.8(r)-13(o)-14(c)-6.8(e)-20.3(s)-19.8(s)-23.6(in)-8.9(g)2(:)]TJ /T1_2 1 Tf -0.004 Tc 1.433 Tw 10.517 0 Td [( )0.5(Al)-5.5(b)-9.9(e)-5.7(r)-42.2(t)]TJ /Span<>> BDC 4.068 0 Td ( )Tj EMC 1.661 0 Td (Z.)Tj /Span<>> BDC 0.736 0 Td ( )Tj EMC 1.662 0 Td [(Ali)5.1(b)-9.8(e)-4.3(k)8.9(o)-4.6(v)29.6(,)-4( )]TJ 0 Tc 0 Tw -18.644 -1.218 Td [(V)23(e)-1.7(r)7.7(a)]TJ /Span<>> BDC ( )Tj EMC [(A)-12.5(.)]TJ /Span<>> BDC ( )Tj EMC [(K)0.7(h)6.2(i)0.9(t)2.3(ar)-40.2(y)3.8(a)-0.8(n)]TJ /T1_1 1 Tf 1.057 Tw T* [(W)3.1(r)-48(i)-6(t)-37.4(i)7.1(n)-1.9(g o)-2.2(f t)-16.7(h)-5.3(e t)-15.1(e)-23.9(x)-36(t)-20.1(:)]TJ /T1_2 1 Tf [( S)15.8(u)2.8(l)4.8(e)-2(i)8.5(m)4.3(a)-0.8(n)]TJ /Span<>> BDC ( )Tj EMC [(A)-12.6(.)]TJ /Span<>> BDC ( )Tj EMC [(A)-0.8(d)1.5(i)12.4(z)12.4(o)-0.6(v)33.6(, )]TJ 0 Tw T* [(A)3.8(n)4.8(a)-3(s)-10.7(t)2.3(a)-3(s)-8.2(iy)3.8(a)]TJ /Span<>> BDC ( )Tj EMC [(\201)-2.3(.)]TJ /Span<>> BDC ( )Tj EMC [(G)-1.4(o)-1.1(l)3(o)-0.6(v)-28.6(i)8.4(n)4.8(a)]TJ /T1_1 1 Tf 0.006 Tc -0.006 Tw T* [(E)11.6(dit)-31.4(i)13.1(n)4.1(g)15(:)]TJ /T1_2 1 Tf 0 Tc 0 Tw 3.238 0 Td [( A)3.6(l)4.8(ek)-17.4(s)7.8(a)-0.8(n)-0.6(d)5.2(r)]TJ /Span<>> BDC ( )Tj EMC [(G)-1.4(.)]TJ /Span<>> BDC ( )Tj EMC [(K)0.8(h)6.1(i)1(t)2.3(ar)-40.2(y)3.8(a)-0.8(n)-6(, A)3.8(n)4.8(a)-3(s)-10.7(t)2.4(a)-3(s)-8.3(iy)3.8(a)]TJ /Span<>> BDC ( )Tj EMC [(\201)-2.3(.)]TJ /Span<>> BDC ( )Tj EMC [(G)-1.3(o)-1.1(l)2.9(o)-0.6(v)-28.6(i)8.4(n)4.8(a)]TJ /T1_0 1 Tf 0.023 Tw -3.238 -2.436 Td (\255\026\036\031\036\025\034\224 \017\225 \032\026\020\017\022\032\221)Tj /T1_1 1 Tf 0.063 Tw T* (\216\017\021\026\030\034\016\027 \202\035\036\022\f\026\027\007\030 \206\ \036\024\030\020\017\036\r\017\004)Tj /Span<>> BDC ( )Tj EMC (\227 \007\024\022\021\024\030 \n\036\007\017\006\017\027)Tj 0 Tw (-)Tj 0.099 Tw T* (\f\022\017\b \027\026\031\022, \023\030\024\235\036\f\f\024\030, \026\r\ . \022\026\235\036\007\030\024\005 \b\017\030\031\030\020\017\004\036\f\022\ \017\b )Tj -0.026 Tw T* (\002\024\035\036\027\036\005 \225 3 \217\024\f\021\206\204\211, \026\r\ . \b\017\030\031\030\020\017\004\036\f\022\017\n \024\021\007\036\035\036\ \027\017)Tj 0 Tw (-)Tj 0.055 Tw T* (\036\n \223\211\003 \025\207 \217\240\212-\204\036\007\017\006\017\027\026\ \020.)Tj /Span<>> BDC ( )Tj EMC (\217\024\f\021\024\r-\027\026-\212\024\027\031; ORCID: )Tj 0 Tw T* (0000-0002-2108-2362)Tj -0.009 Tw T* (\202\007\017\024\r \221\031\035\036\005\n\026\027 \202\035\017\036\r\017\ \004)Tj /Span<>> BDC ( )Tj EMC (\227 \r\030\026\004-\b\017\030\031\030\020 \b\017\030\031\030\020\017\004\ \036)Tj 0 Tw (-)Tj -0.008 Tw T* (\f\022\024\020\024 \024\021\007\036\035\036\027\017\016 \223\211\003 \025\ \207 \217\240\212-\204\036\007\017\006\017\027\026 \020.)Tj /Span<>> BDC ( )Tj EMC (\217\024\f\021\024\r-\027\026-)Tj 0 Tw T* (\212\024\027\031; ORCID: 0000-0002-2173-2281)Tj -0.064 Tw T* [(\202\035\017\002\036\022\024\r )0.5(\202\035\034\002\036\030\021 )0.6(\003\026\031\030\002\036\022\024\r\017\004)]TJ /Span<>> BDC ( )Tj EMC 13.047 0 Td [(\227 )0.5(\022\026\027\007\017\007\026\021 )0.5(\n\036\007\017\006\017\027)]TJ 0 Tw (-)Tj 0.105 Tw -13.047 -1.218 Td [(\f\022\017\b )0.5(\027\026\031\022, )0.5(\007\024\006\036\027\021 )0.6(\022\026\235\036\007\030\t )0.5(\b\017\030\031\030\020\017\004\036\f\022\017\b )0.6(\002\024\035\036\027\036\005 )]TJ 0.033 Tw 23.244 38.97 Td (\225 3 \217\024\f\021\206\204\211, \r\030\026\004-\b\017\030\031\030\020\ \b\017\030\031\030\020\017\004\036\f\022\024\020\024 \024\021\007\036\035\ \036\027\017\016 )Tj -0.006 Tw T* (\223\211\003 \025\207 \217\240\212-\204\036\007\017\006\017\027\026; ORC\ ID: 0000-0003-4724-3774)Tj 0.252 Tw T* (\025\017\f\035\016\022\024\r \200\026\f\017\035\017\005 \203\017\022\024\ \035\026\036\r\017\004)Tj /Span<>> BDC ( )Tj EMC (\227 \r\030\026\004-\b\017\030\031\030\020 \b\017)Tj 0 Tw (-)Tj 0.573 Tw T* (\030\031\030\020\017\004\036\f\022\024\020\024 \024\021\007\036\035\036\027\ \017\016 \223\211\003 \025\207 \217\240\212-\204\036\007\017\006\017\027\ \026 )Tj 0 Tw T* (\020.)Tj /Span<>> BDC ( )Tj EMC (\217\024\f\021\024\r-\027\026-\212\024\027\031; ORCID: 0000-0003-4769-31\ 93)Tj 0.129 Tw T* (\210\030\036\b\024\r \202\035\036\022\f\036\005 \202\027\026\021\024\035\ \034\036\r\017\004)Tj /Span<>> BDC ( )Tj EMC (\227 \022\026\027\007\017\007\026\021 \n\036\007\017\006\017\027)Tj 0 Tw (-)Tj 0.105 Tw 0 -1.218 TD [(\f\022\017\b )0.5(\027\026\031\022, )0.5(\007\024\006\036\027\021 )0.6(\022\026\235\036\007\030\t )0.5(\b\017\030\031\030\020\017\004\036\f\022\017\b )0.6(\002\024\035\036\027\036\005 )]TJ 0.033 Tw 0 -1.218 TD (\225 3 \217\024\f\021\206\204\211, \r\030\026\004-\b\017\030\031\030\020\ \b\017\030\031\030\020\017\004\036\f\022\024\020\024 \024\021\007\036\035\ \036\027\017\016 )Tj 0.32 Tw T* (\223\211\003 \025\207 \217\240\212-\204\036\007\017\006\017\027\026 \020\ .)Tj /Span<>> BDC ( )Tj EMC (\217\024\f\021\024\r-\027\026-\212\024\027\031; ORCID: )Tj 0 Tw T* (0000-0003-3782-2860)Tj 0.448 Tw T* (\216\017\021\026\030\034\016\027 \200\036\030\026 \202\035\036\022\f\026\ \027\007\030\024\r\027\026)Tj /Span<>> BDC ( )Tj EMC (\227 \024\030\007\017\027\026\021\024\030 \022\026)Tj 0 Tw (-)Tj 0.025 Tw T* (\235\036\007\030\t \b\017\030\031\030\020\017\004\036\f\022\017\b \002\024\ \035\036\027\036\005 \225 3 \217\024\f\021\206\204\211; ORCID: )Tj 0 Tw 0 -1.218 TD (0000-0002-6191-1444)Tj 0.245 Tw 0 -1.218 TD (\210\023\035\017\n\026\b \025\f\036\027\017\016 \221\036\030\020\036\036\ \r\027\026)Tj /Span<>> BDC ( )Tj EMC (\227 \024\030\007\017\027\026\021\024\030 \022\026\235\036\007\030\t )Tj 0.778 Tw 0 -1.218 TD (\b\017\030\031\030\020\017\004\036\f\022\017\b \002\024\035\036\027\036\ \005 \225)Tj /Span<>> BDC [( )886( )]TJ EMC 13.078 0 Td (3 \217\024\f\021\206\204\211; ORCID: )Tj 0 Tw -13.078 -1.218 Td (0000-0001-5632-1469)Tj 0.645 Tw T* (\206\024\035\024\r\017\027\026 \202\027\026\f\021\026\f\017\016 \202\027\ \007\030\036\036\r\027\026)Tj /Span<>> BDC ( )Tj EMC (\227 \r\030\026\004-\b\017\030\031\030\020 )Tj 0.856 Tw T* (\223\211\003 \253\025\035\017\027\017\004\036\f\022\026\016 \002\024\035\ \034\027\017\006\026 \253\217\240\212-\204\036\007\017\006\017\027\026\273\ , )Tj 0.409 Tw T* (\020.)Tj /Span<>> BDC ( )Tj EMC (\217\024\f\021\024\r-\027\026-\212\024\027\031; \026\f\023\017\030\026\027\ \021 \022\026\235\036\007\030\t \b\017\030\031\030\020\017\004\036)Tj 0 Tw (-)Tj 0.358 Tw T* [(\f\022\017\b )0.5(\002\024\035\036\027\036\005 \225)]TJ /Span<>> BDC [( )466( )]TJ EMC 8.001 0 Td [(3 \205\206\207\210\211 )0.5(\200\210 \253\217\024\f\021\206\204\211\273; )0.5(ORCID: )]TJ 0 Tw -8.001 -1.218 Td (0000-0001-5647-1192)Tj /T1_0 1 Tf 0.023 Tw 0 -2.436 TD (INFORMATION ABOUT THE AUTHORS)Tj /T1_1 1 Tf 0 Tw 0 -1.218 TD [(Alek)-10(sandr G. Khi)-23.8(t)15(ar)-24(y)22(an)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0002-2108-2362)Tj T* [(Suleiman A. A)15.1(dizov)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0002-2173-2281)Tj T* [(Alber)-21.9(t Z. Al)-30.9(ibekov)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0003-4724-3774)Tj T* [(V)25(asil)-31(iy N. Kisl)35.1(y)22(akov)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0003-4769-3193)Tj T* [(Alek)-10(se)-10.9(y A. Or)-24(ekhov)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0003-3782-2860)Tj T* [(V)30(er)-33(a A. Khi)-23.9(t)15(ar)-23.9(y)22(an)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0002-6191-1444)Tj T* [(K)25(seniy)22(a S. Opl)-30.9(imakh)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0001-5632-1469)Tj T* [(Anast)15(asiy)22.1(a \202. Gol)30(ov)-16(ina)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0001-5647-1192)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 70.936 298.5999 Tm [(\r\031\024\034\033)48(\026)45(\024)-10(\223\033)48(\026)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0 Tc 0.006 Tw 8 0 0 8 70.8661 285.7652 Tm (1.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (\003\017\021\021\026)Tj /Span<>> BDC ( )Tj EMC (\212.\200., \221\031\002\002\024\021\017\027)Tj /Span<>> BDC ( )Tj EMC (\200.\204. \215\030\017\n\036\027\036\027\017\036 \023\030\024\020\030\026\ \n\n\t \024\023\021\017\n\017\026\006\017\017 )Tj 0.034 Tw -1.296 -1.25 Td (\023\036\030\017\024\023\036\030\026\006\017\024\027\027\024\020\024 \r\036\ \007\036\027\017\016 \002\024\035\034\027\t\b \r)Tj /Span<>> BDC ( )Tj EMC (\023\035\026\027\024\r\024\005 \022\024\035\024\030\036\022\021\026\035\034\ \027\024\005 )Tj 0 Tw 0 -1.25 TD (\b\017\030\031\030\020\017\017. )Tj /T1_2 1 Tf 4.369 0 Td (\222\n\023\n\033\032\n\013\024\n\023\n\202\025\002.)Tj /T1_1 1 Tf 0.023 Tw ( 2013;1:15\22619.)Tj 0.074 Tw -4.369 -1.25 Td (2.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(R)-24(ichar)-23.9(d)]TJ /Span<>> BDC ( )Tj EMC [(L, A)-13.9(bcar)-37(ian)]TJ /Span<>> BDC ( )Tj EMC [(H. Anal f)-28(istul)-15.9(a: p)25(r)-36.9(inc)-24(iples and mana)-17(gement. )]TJ /T1_2 1 Tf 0 Tw -1.296 -1.25 Td [(Sp)46(r)-37(ing)12(er)]TJ /T1_1 1 Tf 0.023 Tw (. 2014; 199 \030.)Tj 0.152 Tw T* (3.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Her)-32(old)]TJ /Span<>> BDC ( )Tj EMC 3.068 0 Td [(A, )0.5(L)35(ehur )0.6(P-A, )0.6(Ma)15(tzel)]TJ /Span<>> BDC ( )Tj EMC 8.719 0 Td [(KE, )0.6(e)-12(t)]TJ /Span<>> BDC ( )Tj EMC 2.786 0 Td [(al. )0.6(Col)30(op)25(r)-32(o)-16(c)-16(t)17(ol)30(o)-16(g)16(y, )0.6(Eur)-32(opean )]TJ 0.023 Tw -15.869 -1.25 Td [(manual of medic)-24(ine. )]TJ /T1_2 1 Tf 0 Tw [(Sp)46(r)-36.9(ing)12(er)]TJ /T1_1 1 Tf 0.023 Tw (. 2017; 465 \030.)Tj 0.318 Tw T* (4.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Bal)16(c)-24(iscue)-11.9(t)15(a)]TJ /Span<>> BDC ( )Tj EMC 5.165 0 Td [(Z, )0.5(U)15.1(r)-37(ibe)]TJ /Span<>> BDC ( )Tj EMC 3.907 0 Td [(N, )0.5(Bal)16.1(c)-24(iscue)-12(t)15(a)]TJ /Span<>> BDC ( )Tj EMC 6.49 0 Td [(I, )0.5(e)-12(t)]TJ /Span<>> BDC ( )Tj EMC 2.491 0 Td [(al. )0.6(R)12.9(ec)-15.9(t)15(al )0.5(ad)-17(v)-15(ance)]TJ 0 Tw (-)Tj 0.201 Tw -19.349 -1.25 Td [(ment fl)-15.9(ap for t)-13(he tr)-23.9(ea)15(tment of com)10(ple)-18(x cr)-24(ypt)17(o)-16(gl)-16(andul)-15.9(ar anal f)-28(is)]TJ 0 Tw (-)Tj 0.173 Tw T* [(tul)-16(as: a sy)-12.9(stema)15(t)-32(ic r)-24(ev)-16(iew and me)-12(t)15.1(a-anal)35(y)-13(sis. )]TJ /T1_2 1 Tf (Int J Colorectal Dis.)Tj /T1_1 1 Tf 0 Tw ( )Tj 0.023 Tw T* [(2017;32\(5\):599\226609. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1007/s00384-017-2779-7)Tj 0 0 0 1 k /GS1 gs -0.002 Tc 0.035 Tw T* (5.)Tj /Span<>> BDC ( )Tj EMC 1.29 0 Td [(Ama)15(t)17(o)]TJ /Span<>> BDC ( )Tj EMC [(A, Bo)17(t)-30(t)-32(ini)]TJ /Span<>> BDC ( )Tj EMC [(C, De Nar)-24(di)]TJ /Span<>> BDC ( )Tj EMC [(P, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Ev)-15(al)35(ua)15(t)-32(ion and mana)-17(gement)-2( )]TJ 0.077 Tw -1.29 -1.25 Td [(of per)-36.9(ianal abscess and anal f)-28(istul)-16(a: SICCR posi)-24(t)-32(ion st)15(a)15.1(tement. )]TJ /T1_2 1 Tf 0.002 Tw [(T)54(ech)-2( )]TJ T* [(Colop)46(roctol)]TJ /T1_1 1 Tf -0.014 Tw [(. 2020;24\(2\):127\226143. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0.002 Tw (10.1007/s10151-019-02144-1)Tj 0 0 0 1 k /GS1 gs 0 Tc 0.196 Tw T* (6.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (Emile)Tj /Span<>> BDC ( )Tj EMC (SH, Khan)Tj /Span<>> BDC ( )Tj EMC [(SM, A)15(dejumo)]TJ /Span<>> BDC ( )Tj EMC [(A, e)-11.9(t)]TJ /Span<>> BDC ( )Tj EMC [(al. L)-32(iga)15(t)-32(ion of inter)-9.9(sphinc)]TJ 0 Tw (-)Tj 0.181 Tw -1.296 -1.25 Td [(ter)-37(ic )0.5(f)-28(istul)-15.9(a )0.5(tr)-33(a)-17(c)-16(t )0.5(\(LIFT\) )0.5(in )0.5(tr)-24(ea)15(tment )0.5(of anal )0.5(f)-28(istul)-15.9(a: )0.5(An )0.5(upd)42(a)15(ted )]TJ 0.188 Tw T* [(sy)-13(stema)15.1(t)-32(ic )0.5(r)-24(ev)-15.9(iew, )0.5(me)-12(t)15.1(a-anal)35(y)-13(sis, )0.6(and )0.5(me)-12(t)15(a-r)-23.9(egr)-24(ession )0.6(of )0.5(t)-13(he )0.6(p)25(r)-24(e)]TJ 0 Tw (-)Tj 0.233 Tw T* [(dic)-16(t)17(or)-10(s )0.5(of )0.5(f)16(ail)35.1(ur)-24(e. )]TJ /T1_2 1 Tf 0 Tw 7.877 0 Td [(Surg)12(er)-43(y)]TJ /T1_1 1 Tf 0.233 Tw [(. )0.5(2020;167\(2\):484\226492. )0.6(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw 15.446 0 Td (10.1016/j.)Tj -23.324 -1.25 Td [(sur)-32(g.2019.09.012)]TJ 0 0 0 1 k /GS1 gs 0.22 Tw T* (7.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Elfek)-15.9(i)]TJ /Span<>> BDC ( )Tj EMC 2.718 0 Td [(H, )0.5(S)-15.9(hal)-16(ab)12(y)]TJ /Span<>> BDC ( )Tj EMC 4.833 0 Td [(M, )0.5(Emile)]TJ /Span<>> BDC ( )Tj EMC 3.966 0 Td [(SH, )0.5(e)-11.9(t)]TJ /Span<>> BDC ( )Tj EMC 2.995 0 Td [(al. )0.6(A )0.5(sy)-13(stema)15.1(t)-32(ic )0.5(r)-24(ev)-15.9(iew )0.5(and )]TJ 0.236 Tw -15.808 -1.25 Td [(me)-12(t)15(a-anal)35.1(y)-13(sis of t)-13(he safe)-11.9(t)-10(y and ef)-55.9(f)-28(ica)-17(cy of f)-28(istul)-16(a l)-16(aser cl)30(osur)-24(e. )]TJ /T1_2 1 Tf 0.31 Tw 29.055 25 Td [(T)54(ech Colop)46(roctol)]TJ /T1_1 1 Tf [(. 2020;24\(4\):265\226274. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1007/s10151-020-)Tj T* (02165-1)Tj 0 0 0 1 k /GS1 gs 0.321 Tw T* (8.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(F)10(r)-32(ountzas)]TJ /Span<>> BDC ( )Tj EMC [(M, S)15(ter)-32(gios)]TJ /Span<>> BDC ( )Tj EMC [(K, Nikol)-16(aou)]TJ /Span<>> BDC ( )Tj EMC [(C, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Could F)-19(iL)-31.9(aC\250 be )]TJ 0.119 Tw -1.296 -1.25 Td [(ef)-56(fec)-16(t)-31.9(i)-16(ve in t)-13(he tr)-24(ea)15(tment of anal f)-28(istul)-16(as? A sy)-13(stema)15.1(t)-32(ic r)-24(ev)-16(iew of )]TJ 0.019 Tw T* [(obser)-32(v)-15(a)15.1(t)-32(ional studies and p)25(r)-32(opor)-22(t)-31.9(ional me)-12(t)15(a-anal)35(y)-13(sis. )]TJ /T1_2 1 Tf (Colorectal Dis)Tj /T1_1 1 Tf 0 Tw (. )Tj 0.023 Tw T* [(2020;22\(12\):1874\2261884. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1111/codi.15148)Tj 0 0 0 1 k /GS1 gs 0.033 Tw T* (9.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(G\366t)-30(tgens)]TJ /Span<>> BDC ( )Tj EMC [(KW, Smee)-11.9(ts)]TJ /Span<>> BDC ( )Tj EMC [(RR, S)15(t)15(assen)]TJ /Span<>> BDC ( )Tj EMC [(LP, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Sy)-13(stema)15.1(t)-32(ic r)-24(ev)-16(iew and )]TJ 0.314 Tw -1.296 -1.25 Td [(me)-12(t)15(a-anal)35.1(y)-13(sis of sur)-32(gical inter)-32(vent)-32(ions for high cr)-24(ypt)17(o)-16(gl)-16(andul)-15.9(ar )]TJ -0.022 Tw T* [(per)-37(ianal f)-28(istul)-15.9(a. )]TJ /T1_2 1 Tf (Int J Colorectal Dis. )Tj /T1_1 1 Tf [(2015;30:583\226593. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1007/)Tj T* (s00384-014-2091-8)Tj 0 0 0 1 k /GS1 gs 0.278 Tw T* (10.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Al)-16(ander)]TJ /Span<>> BDC ( )Tj EMC 3.603 0 Td [(JT, )0.5(K)-15.9(aar)-22(t)-32(inen)]TJ /Span<>> BDC ( )Tj EMC 6.083 0 Td [(I, )0.5(L)-31.9(aak)-10(so)]TJ /Span<>> BDC ( )Tj EMC 4.328 0 Td [(A, )0.5(e)-11.9(t)]TJ /Span<>> BDC ( )Tj EMC 2.591 0 Td [(al. )0.5(A )0.6(r)-24(ev)-15.9(iew )0.5(of )0.5(ind)-15.9(o)]TJ 0 Tw (-)Tj 0.017 Tw -18.401 -1.25 Td [(cy)22(anine gr)-24(een fl)35(uor)-23.9(escent ima)-17(ging in sur)-32(ger)-24(y. )]TJ /T1_2 1 Tf (Int J Biomed Imaging)Tj /T1_1 1 Tf 0 Tw (. )Tj 0.023 Tw T* [(2012;2012:940585. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1155/2012/940585)Tj 0 0 0 1 k /GS1 gs 0.038 Tw T* (11.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Boni)Tj /Span<>> BDC ( )Tj EMC [(L, Dav)-16(id)]TJ /Span<>> BDC ( )Tj EMC (G, Mangano)Tj /Span<>> BDC ( )Tj EMC [(A, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. A. f)-28(inger hut cl)-31(inical appl)-31(ica)]TJ 0 Tw (-)Tj 0.113 Tw -1.796 -1.25 Td [(t)-32(ions of ind)-16(o)-16(cy)22(anine gr)-23.9(een \(ICG\) enhanced fl)35(uor)-24(escence in l)-16(ap)32(ar)-31.9(o)]TJ 0 Tw (-)Tj 0.053 Tw T* [(scopic sur)-32(ger)-24(y. )]TJ /T1_2 1 Tf (Surg. Endosc. )Tj /T1_1 1 Tf [(2015;29\(7\):2046\2262055. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1007/)Tj T* (s00464-014-3895-x)Tj 0 0 0 1 k /GS1 gs 0.081 Tw T* [(1)72(2)35(.)]TJ /Span<>> BDC ( )Tj EMC 1.689 0 Td [(R)13(einhar)-22(t)]TJ /Span<>> BDC ( )Tj EMC [(MB, Hunt)-32(ing)17(t)17(on)]TJ /Span<>> BDC ( )Tj EMC [(CR, Bl)-16(air)]TJ /Span<>> BDC ( )Tj EMC [(LJ, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Ind)-16(o)-16(cy)22(anine gr)-24(een: )]TJ 0.15 Tw -1.689 -1.25 Td [(hist)17(or)-36.9(ical conte)-17.9(xt)72(, cur)-23.9(r)-24(ent )0.5(appl)-31(ica)15(t)-32(ions)48(, )0.5(and )0.5(futur)-24(e )0.5(consider)-33(a)15(t)-31.9(ions)16(. )]TJ /T1_2 1 Tf 0.023 Tw T* [(Surg Innov)16(at)]TJ /T1_1 1 Tf [(. 2)20(0)72(1)40(6;2)40(3\(2\):1)40(66\2261)95(7)49.9(5)25.1(. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw [(1)45(0)15(.)45(1)136(1)95(7)72(7)104(/)72(1)40(5)19.9(5)30(3)40(3)35(5)20(06)101(1)40(5)15(604)25(05)30(3)]TJ 0 0 0 1 k /GS1 gs 0.062 Tw T* (13.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Gupt)15(a)]TJ /Span<>> BDC ( )Tj EMC [(P, Misr)-33(a)]TJ /Span<>> BDC ( )Tj EMC [(S, K)25(umar)]TJ /Span<>> BDC ( )Tj EMC [(S)17(S, e)-11.9(t)]TJ /Span<>> BDC ( )Tj EMC [(al. R)13(elev)-15(ance of poster)-36.9(ior gastr)-37(ic )]TJ 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 0 Tw 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\033\030\031\030\213\b)-20.9(\035\231\213\233\t \021\032)50(\b)42(\032\231\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj -51.938 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 23, \023\0221)69(, 202)69(4)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 23, \023\0221)69(, 202)69(4)]TJ /T1_5 1 Tf 25 0 0 25 28.14 56.0378 Tm (98)Tj ET endstream endobj 1573 0 obj <>/Border[0 0 0]/H/N/Rect[157.286 193.061 250.758 183.765]/Subtype/Link/Type/Annot>> endobj 1574 0 obj <>/Border[0 0 0]/H/N/Rect[194.897 163.061 291.969 153.605]/Subtype/Link/Type/Annot>> endobj 1575 0 obj <>/Border[0 0 0]/H/N/Rect[257.457 123.061 291.968 113.605]/Subtype/Link/Type/Annot>> endobj 1576 0 obj <>/Border[0 0 0]/H/N/Rect[70.8661 113.061 128.002 103.765]/Subtype/Link/Type/Annot>> endobj 1577 0 obj <>/Border[0 0 0]/H/N/Rect[453.754 293.061 524.409 283.605]/Subtype/Link/Type/Annot>> endobj 1578 0 obj <>/Border[0 0 0]/H/N/Rect[303.307 283.061 330.123 273.765]/Subtype/Link/Type/Annot>> endobj 1579 0 obj <>/Border[0 0 0]/H/N/Rect[401.727 243.061 467.735 233.765]/Subtype/Link/Type/Annot>> endobj 1580 0 obj <>/Border[0 0 0]/H/N/Rect[494.498 213.061 524.409 203.605]/Subtype/Link/Type/Annot>> endobj 1581 0 obj <>/Border[0 0 0]/H/N/Rect[303.307 203.061 366.867 193.765]/Subtype/Link/Type/Annot>> endobj 1582 0 obj <>/Border[0 0 0]/H/N/Rect[383.359 173.061 456.815 163.765]/Subtype/Link/Type/Annot>> endobj 1583 0 obj <>/Border[0 0 0]/H/N/Rect[494.498 143.061 524.409 133.605]/Subtype/Link/Type/Annot>> endobj 1584 0 obj <>/Border[0 0 0]/H/N/Rect[303.307 133.061 366.419 123.765]/Subtype/Link/Type/Annot>> endobj 1585 0 obj <>/Border[0 0 0]/H/N/Rect[431.316 103.061 517.389 93.6052]/Subtype/Link/Type/Annot>> endobj 1598 0 obj <> endobj 1597 0 obj <> endobj 1596 0 obj <> endobj 1595 0 obj <> endobj 1594 0 obj <> endobj 1593 0 obj <> endobj 1592 0 obj <> endobj 1591 0 obj <> endobj 1590 0 obj <> endobj 1589 0 obj <> endobj 1588 0 obj <> endobj 1587 0 obj <> endobj 1586 0 obj <> endobj 1494 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(IC)31(G-\013\001\202\220\025\202\002\013\225\220\205 \r\022\025\227\016\001\n\016\ \n\013\017\016\006)-10(\026\r\013 \225\025\002\024\220\002\025\r\013\001\220\205 )]TJ 0 -1 TD [(\221\025\007\001\025\006)-9.9(\007\025\203\001\025\202)10(\025 \221\002\205\024\025\n\220\016\017\001\025\202)10(\025 \007\025\006\n\215)-19.9(\026)11(\013 \221\002\220\022\025\221\016\002\013\026\220\r\001\025\024 )]TJ T* [(\007\016\017\016\001\220\220 \006)-10(\007\025\217\001\020\207 \221\002\205\024\025\n\220\016\017\001\020\207\ \006\r\220\224\016\203)]TJ 31.181 2 Td [(IC)31(G-angiogr)21.1(aph)31(y for r)31(ectal adv)10(ancement flap in patients with anal f)-21(istulas)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf -0.01 Tc 0.37 Tw 10 0 0 10 42.5197 724.8299 Tm (\017)Tj /Span<>> BDC ( )Tj EMC [(\024\f\027\024\r\027\t\b \023\030\017\004\017\027 \027\036\002\035\026\020\ \024\023\030\017\016\021\027\t\b \030\036\031\035\034\021\026\021\024\r\ )-10( )]TJ 0.225 Tw 0 -1.218 TD (\024\023\036\030\026\021\017\r\027\024\020\024 \035\036\004\036\027\017\016\ \016\r\035\016\036\021\f\016 \017\n\036\027\027\024 \027\036\007\024\f\021\ \026\021\024\004)Tj 0 Tc 0 Tw (-)Tj -0.01 Tc 0.067 Tw T* (\027\024\f\021\034 \022\030\024\r\024\f\027\026\002\032\036\027\017\016 \ \023\024\035\027\024\f\035\024\005\027\024\020\024 \035\024\f\022\031\021\ \026, \r)Tj /Span<>> BDC ( )Tj EMC (\f\r\016)Tj 0 Tc 0 Tw (-)Tj -0.01 Tc 0.034 Tw T* (\017 \f)Tj /Span<>> BDC ( )Tj EMC [(\004\036\n, \017\027\021\030\026\024\023\036\030\026\006\017\024\027\027\ \026\016 \024\006\036\027\022\026 \022\030\024\r\024\f\027\026\002\032\036\ \027\017\016)-10( )]TJ -0.073 Tw T* (\235\024\030\n\017\030\031\036\n\024\020\024 \035\024\f\022\031\021\026 \ \017\n\036\036\021 \022\030\026\005\027\036 \r\026\032\027\024\036 \027\ \026\004\036\027\017\036.)Tj 0 Tc 0.159 Tw T* (\200 \007\026\027\027\024\n \026\f\023\036\022\021\036 \007\017\026\020\027\ \024\f\021\017\004\036\f\022\017 \006\036\027\027\t\n \016\r\035\016\036\ \021\f\016 )Tj 0.039 Tw 0 -1.218 TD (\n\036\021\024\007 \235\035\031\024\030\036\f\006\036\027\021\027\024\005\ ICG-\027\026\r\017\020\026\006\017\017, \023\024\r\024\035\016\033\013\ \017\005 )Tj 0.056 Tw 0 -1.218 TD (\r)Tj /Span<>> BDC ( )Tj EMC 0.762 0 Td [(\030\036\032\017\n\036 )0.5(\030\036\026\035\034\027\024\020\024 )0.5(\r\030\036\n\036\027\017 )0.5(\024\006\036\027\017\021\034 )0.6(\026\027\020\017\024\026\030\b\017\021\036\022)]TJ 0 Tw (-)Tj 0.009 Tw -0.762 -1.218 Td (\021\024\027\017\022\031 \021\022\026\027\036\005 \017)Tj /Span<>> BDC ( )Tj EMC (\024\030\020\026\027\024\r \017)Tj /Span<>> BDC ( )Tj EMC (\f\r\024\036\r\030\036\n\036\027\027\024 \253\017\027\007\017\r\017\007\031\ )Tj 0 Tw (-)Tj 0.088 Tw T* (\026\035\017\017\030\024\r\026\021\034\273 \024\023\036\030\026\021\017\ \r\027\031\033 \021\026\022\021\017\022\031. \025\024\035\024\030\036\022\ \021\026\035\034\027\026\016 )Tj 0.378 Tw T* (\b\017\030\031\030\020\017\016, \r)Tj /Span<>> BDC ( )Tj EMC (\004\026\f\021\027\024\f\021\017, \024\022\026\026\035\026\f\034 \024\007\ \027\024\005 \017)Tj /Span<>> BDC ( )Tj EMC (\020\035\026\r)Tj 0 Tw (-)Tj 0.346 Tw T* (\027\t\b \024\002\035\026\f\021\036\005 \007\035\016 \022\035\017\027\017\ \004\036\f\022\024\020\024 \023\030\017\n\036\027\036\027\017\016 ICG-)Tj 0.202 Tw 0 -1.218 TD (\026\027\020\017\024\020\030\026\235\017\017, \021\026\022 \022\026\022 \ \023\024\r\024\035\016\036\021 \022\024\035\017\004\036\f\021\r\036\027\ \027\024 \017)Tj 0 Tw (-)Tj 0.461 Tw 0 -1.218 TD (\n\036\030\017\021\034 \031\030\024\r\036\027\034 \022\030\024\r\024\f\027\ \026\002\032\036\027\017\016 \022\017\001\022\017, \024\006\036\027\017\021\ \034 )Tj 0.085 Tw 0 -1.218 TD (\017\027\007\017\r\017\007\031\026\035\034\027\t\036 \024\f\024\002\036\027\ \027\024\f\021\017 \026\027\026\021\024\n\017\017 \f\024\f\031\007\017\f\ \021\024\020\024 )Tj 0.056 Tw T* (\030\031\f\035\026 \017, \r)Tj /Span<>> BDC ( )Tj EMC (\030\036\031\035\034\021\026\021\036, \024\002\036\f\023\036\004\017\021\ \034 \r\t\f\024\022\031\033 \030\036\031\035\034\021\026)Tj 0 Tw (-)Tj 0.082 Tw T* (\021\017\r\027\024\f\021\034 \017)Tj /Span<>> BDC ( )Tj EMC [(\002\036\024\023\026\f\027\024\f\021\034 )0.5(\r\t\023\024\035\027\016\036\n\024\020\024 \024\023\036\030\026\021\017\r\ \027\024)]TJ 0 Tw (-)Tj T* (\020\024 \r\n\036\001\026\021\036\035\034\f\021\r\026 [22].)Tj 0.006 Tw T* (\200 \023\030\024\r\036\007\036\027\027\024\n \027\026\n\017 \017\f\f\035\ \036\007\024\r\026\027\017\017 \023\024\f\030\036\007\f\021\r\024\n ICG-\ )Tj 0.436 Tw T* (\026\027\020\017\024\020\030\026\235\017\017 \f)Tj /Span<>> BDC ( )Tj EMC [(\023\024\f\035\036\007\031\033\013\036\005 )0.5(\b\030\024\027\024\n\036\021\030\017\036\005 )0.5(\027\026\n\017 )]TJ 0.32 Tw T* [(\002\t\035\017 \017\031\004\036\027\t \023\026\030\026\n\036\021\030\t \ )0.5(\026\027\020\017\024\026\030\b\017\021\036\022\021\024\027\017\022\017 )0.5(\017\027)]TJ 0 Tw (-)Tj 0.19 Tw T* (\021\026\022\021\027\024\005 \023\030\016\n\024\005 \022\017\001\022\017\ \017)Tj /Span<>> BDC ( )Tj EMC (\235\024\030\n\017\030\031\036\n\t\b \023\024\035\027\024\f\035\024\005)Tj 0 Tw (-)Tj 0.061 Tw T* [(\027\t\b )0.5(\035\024\f\022\031\021\024\r )0.6(\023\030\017)]TJ /Span<>> BDC ( )Tj EMC 7.644 0 Td [(\023\030\024\r\036\007\036\027\017\017 )0.6(\002\024\022\024\r\024\020\024 )0.5(\006\017\030\022\031\035\016\021\024\030)]TJ 0 Tw (-)Tj 0.158 Tw -7.644 -1.218 Td (\027\024\020\024 \026\030\036\f\021\026. \224\021\024 \023\024\r\024\035\ \017\035\024 \f\n\024\007\036\035\017\030\024\r\026\021\034 \031\f\035\024\ \r\017\016 )Tj 0.212 Tw T* (\007\035\016 \024\002\255\036\022\021\017\r\027\024\005 \024\006\036\027\ \022\017 \r\035\017\016\027\017\016 \001\017\030\017\027\t \r\t\022\030\026\ \017)Tj 0 Tw (-)Tj 0.066 Tw T* (\r\026\036\n\024\020\024 \035\024\f\022\031\021\026 \027\026)Tj /Span<>> BDC ( )Tj EMC (\022\035\033\004\036\r\t\036 \b\030\024\027\024\n\036\021\030\017\004\036\ \f\022\017\036 \023\026)Tj 0 Tw (-)Tj 0.158 Tw T* [(\030\026\n\036\021\030\t )0.5(\022\030\024\r\024\f\027\026\002\032\036\027\017\016)]TJ /Span<>> BDC ( )Tj EMC 11.262 0 Td [(\227 )0.5(\f\030\036\007\027\036\036 )0.6(\r\030\036\n\016 )0.5(\027\026\004\026\035\026 )]TJ 0 Tw -11.262 -1.218 Td (\026\030\021\036\030\017\026\035\034\027\024\005 \017)Tj /Span<>> BDC ( )Tj EMC (\r\036\027\024\027\024\005 \235\026.)Tj 0.028 Tw T* (\025\026\022 \031\032\036 \024\021\n\036\004\026\035\024\f\034 \r)Tj /Span<>> BDC ( )Tj EMC (\030\026\007\036\035\036 \253\215\026\006\017\036\027\021\t \017)Tj /Span<>> BDC ( )Tj EMC (\n\036\021\024\007\t\273, )Tj 0.099 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC [(\022\026\032\007\024\005 )0.5(\020\030\031\023\023\036 \023\026\006\017\036\027\021\024\r, )0.5(\r\022\035\033\004\036\027\027\t\b )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC (\017\f\f\035\036\007\024)Tj 0 Tw (-)Tj 0.183 Tw T* (\r\026\027\017\036, \030\026\f\023\024\035\024\032\036\027\017\036 \017)Tj /Span<>> BDC ( )Tj EMC (\b\024\007 \026\030\021\036\030\017\005 \023\030\016\n\024\005 \022\017\001\ \022\017 )Tj -0.004 Tw T* (\024\021\035\017\004\026\035\f\016: 1 \020\030\031\023\023\031 \f\024\f\021\ \026\r\017\035\017 \023\026\006\017\036\027\021\t \f)Tj /Span<>> BDC ( )Tj EMC (3-\n\016 \022\030\031\023)Tj 0 Tw (-)Tj -0.014 Tw T* (\027\t\n\017 \007\017\f\021\026\035\034\027\t\n\017 \r\036\021\r\016\n\017\ \023\030\016\n\024\022\017\001\036\004\027\t\b \026\030\021\036\030\017\ \005, )Tj 0.075 Tw T* (\026)Tj /Span<>> BDC ( )Tj EMC (2 \017)Tj /Span<>> BDC ( )Tj EMC (3 \020\030\031\023\023\t)Tj /Span<>> BDC ( )Tj EMC (\227 \002\024\035\034\027\t\036 \f)Tj /Span<>> BDC ( )Tj EMC (4 \017)Tj /Span<>> BDC ( )Tj EMC (5 \r\036\021\r\016\n\017, \f\024\024\021\r\036\021)Tj 0 Tw (-)Tj 0.096 Tw T* (\f\021\r\036\027\027\024. \211\004\017\021\t\r\026\016 \022\024\035\017\004\ \036\f\021\r\024 \017)Tj /Span<>> BDC ( )Tj EMC (\030\026\f\023\024\035\024\032\036\027\017\036 \007\017\f)Tj 0 Tw (-)Tj 0.084 Tw T* (\021\026\035\034\027\t\b \r\036\021\r\036\005 \023\030\016\n\024\022\017\ \001\036\004\027\t\b \026\030\021\036\030\017\005, \027\026\n\017 \002\t\ \035\017 )Tj 0.235 Tw T* [(\024\023\030\036\007\036\035\036\027\t \020\030\026\027\017\006\t )0.5(\235\024\030\n\017\030\024\r\026\027\017\016 \035\024\f\022\031\021\026 \ \021\026\022\017\n )]TJ 0.023 Tw T* [(\024\002\030\026\024\n, )0.5(\004\021\024\002\t )0.5(\031)]TJ /Span<>> BDC ( )Tj EMC 7.337 0 Td [(\023\026\006\017\036\027\021\024\r )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC 5.27 0 Td [(3-\n\016 )0.5(\007\017\f\021\026\035\034\027\t\n\017 )0.6(\r\036\021)]TJ 0 Tw (-)Tj 0.138 Tw -12.607 -1.218 Td (\r\016\n\017 \023\030\016\n\024\022\017\001\036\004\027\t\b \026\030\021\ \036\030\017\005 \r)Tj /Span<>> BDC ( )Tj EMC (\006\036\027\021\030\036 \035\024\f\022\031\021\026 \027\026)Tj 0 Tw (-)Tj 0.138 Tw T* [(\b\024\007\017\035\f\016 )0.5(\024\007\017\027 )0.5(\f\024\f\031\007, )0.5(\026)]TJ /Span<>> BDC ( )Tj EMC [(\031 )0.5(\023\026\006\017\036\027\021\024\r )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC 16.125 0 Td (4 \017)Tj /Span<>> BDC ( )Tj EMC [(5 )0.5(\r\036\021\r\016\n\017 )]TJ -0.046 Tw -16.125 -1.218 Td (\r)Tj /Span<>> BDC ( )Tj EMC (\021\022\026\027\016\b \235\024\030\n\017\030\031\036\n\024\020\024 \035\ \024\f\022\031\021\026 \027\026\b\024\007\017\035\017\f\034 \007\r\026 \002\ \035\017)Tj 0 Tw (-)Tj T* (\035\036\032\026\013\017\b \f\024\f\031\007\026 \023\024)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\017\235\036\030\017\017.)Tj 0.021 Tw T* (\200 \030\036\031\035\034\021\026\021\036 \002\t\035\024 \031\f\021\026\ \027\024\r\035\036\027\024, \004\021\024 \r)Tj /Span<>> BDC ( )Tj EMC (\017\027\021\026\022\021\027\024\005 \023\030\016)Tj 0 Tw (-)Tj -0.007 Tw T* (\n\024\005 \022\017\001\022\036 \f\030\036\007\027\036\036 \r\030\036\n\016\ \027\026\004\026\035\026 \026\030\021\036\030\017\026\035\034\027\024\005\ \235\026\t )Tj -0.023 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\235\026\t \n\026\022\f\017\n\026\035\034\027\024\005 \235\035\033\024\030\ \036\f\006\036\027\006\017\017 \r\024 \r\f\036\b \017\f\f\035\036)Tj 0 Tw (-)Tj T* (\007\031\036\n\t\b \020\030\031\023\023\026\b \002\t\035\024 \f\024\023\024\ \f\021\026\r\017\n\024.)Tj 0.169 Tw T* (\200 \023\024\f\035\036\007\031\033\013\036\n, \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\235\024\030\n\017\030\024\r\026\027\017\017 \023\024\035\027\024\f\035\024\ \005\027\024\020\024 )Tj 0.337 Tw T* (\035\024\f\022\031\021\026 \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\r\036\007\036\027\017\017 \b\030\024\027\024\n\036\021\030\017\ \017 \r\017\007\036\024\026\023\017\f\036\005 )Tj 0.253 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\031\f\035\024\r\017\016\b \002\024\022\024\r\024\020\024 \006\017\030\022\ \031\035\016\021\024\030\027\024\020\024 \026\030\036\f\021\026 \023\024\ \035\031)Tj 0 Tw (-)Tj 0.207 Tw T* (\004\036\027\t \f\035\036\007\031\033\013\017\036 \007\026\027\027\t\036\ : \r\030\036\n\016 \027\026\f\021\031\023\035\036\027\017\016 \026\030\021\ \036)Tj 0 Tw (-)Tj 0.167 Tw T* (\030\017\026\035\034\027\024\005 \235\026\t \017\027\021\026\022\021\027\ \024\005 \023\030\016\n\024\005 \022\017\001\022\017 \017)Tj /Span<>> BDC ( )Tj EMC (\035\024\f\022\031\021\026 )Tj 0.265 Tw T* (\030\026\035\017\004\027\024\005 \001\017\030\017\027\t \002\t\035\024 \ \f\024\023\024\f\021\026\r\017\n\024, \r)Tj /Span<>> BDC ( )Tj EMC (\021\024 \r\030\036\n\016 )Tj 0.013 Tw T* (\022\026\022 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\001\017\030\017\027\036 \023\024\035\027\024\f\035\024\005\027\024\020\024\ \035\024\f\022\031\021\026 \r)Tj /Span<>> BDC ( )Tj EMC (1/3 \024\022\030\031\032)Tj 0 Tw (-)Tj 0.273 Tw T* (\027\024\f\021\017 \023\030\016\n\024\005 \022\017\001\022\017 \027\026\002\ \035\033\007\026\035\024\f\034 \027\036\027\026\004\017\021\036\035\034\ \027\024\036 )Tj 0.255 Tw 23.244 64.543 Td [(\031\007\035\017\027\036\027\017\036 )0.6(\r\036\027\024\027\024\020\024 )0.5(\024\021\021\024\022\026, )0.6(\r\t\030\026\032\026\033\013\036\036\f\016 )0.6(\r)]TJ /Span<>> BDC ( )Tj EMC 20.818 0 Td (\031\007)Tj 0 Tw (-)Tj 0.194 Tw -20.818 -1.218 Td (\035\017\027\036\027\017\017 \f\030\036\007\027\036\020\024 \r\030\036\n\ \036\027\017 \027\026\f\021\031\023\035\036\027\017\016 \235\026\t \n\026\ \022)Tj 0 Tw (-)Tj 0.075 Tw T* (\f\017\n\026\035\034\027\024\005 \235\035\033\024\030\036\f\006\036\027\006\ \017\017 \007\024)Tj /Span<>> BDC ( )Tj EMC (61,5)Tj /Span<>> BDC ( )Tj EMC (\f., \026)Tj /Span<>> BDC ( )Tj EMC (\023\030\017 \001\017\030\017\027\036 )Tj -0.021 Tw T* (\035\024\f\022\031\021\026 \r)Tj /Span<>> BDC ( )Tj EMC (1/4 \024\022\030\031\032\027\024\f\021\017)Tj /Span<>> BDC ( )Tj EMC (\227 \r)Tj /Span<>> BDC ( )Tj EMC (\007\024\f\021\024\r\036\030\027\024\n \()Tj /T1_2 1 Tf 0 Tw (p)Tj /T1_1 1 Tf -0.021 Tw /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (0,05\) )Tj 0.006 Tw T* (\031\007\035\017\027\036\027\017\017 \f\030\036\007\027\036\020\024 \r\030\ \036\n\036\027\017 \027\026\f\021\031\023\035\036\027\017\016 \235\026\t\ \n\026\022)Tj 0 Tw (-)Tj 0.116 Tw T* (\f\017\n\026\035\034\027\024\005 \235\035\031\024\030\036\f\006\036\027\006\ \017\017 \007\024)Tj /Span<>> BDC ( )Tj EMC (77,6)Tj /Span<>> BDC ( )Tj EMC (\f., \021\024 \036\f\021\034 \r)Tj /Span<>> BDC ( )Tj EMC (1,26 )Tj 0.032 Tw 0 -1.218 TD (\030\026\026 \023\024)Tj /Span<>> BDC ( )Tj EMC (\f\030\026\r\027\036\027\017\033 \f)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\024\r\t\n \023\024\022\026\026\021\036\035\036\n \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027)Tj 0 Tw (-)Tj 0.121 Tw 0 -1.218 TD [(\021\024\r )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC 2.498 0 Td [(\001\017\030\017\027\024\005 )0.6(\235\024\030\n\017\030\031\036\n\024\020\024 )0.5(\035\024\f\022\031\021\026 )0.6(\r)]TJ /Span<>> BDC ( )Tj EMC 14.898 0 Td [(1/3 )0.5(\024\022\030\031\032)]TJ 0 Tw (-)Tj 0.372 Tw -17.396 -1.218 Td (\027\024\f\021\017 \023\030\016\n\024\005 \022\017\001\022\017, \004\021\ \024 \n\024\032\036\021 \002\t\021\034 \024\002\255\016\f\027\036\027\024\ )Tj 0.067 Tw T* (\031\n\036\027\034\001\036\027\017\036\n \022\024\035\035\026\021\036\030\ \026\035\034\027\t\b \f\024\f\031\007\024\r, \031\004\026\f\021\r\031\033\ \013\017\b )Tj 0.18 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\r\036\027\024\027\024\n \024\021\021\024\022\036, \004\021\024, \r)Tj /Span<>> BDC ( )Tj EMC (\f\r\024\033 \024\004\036\030\036\007\034, \n\024\032\036\021 \016\r)Tj 0 Tw (-)Tj 0.01 Tw T* (\035\016\021\034\f\016 \027\036\002\035\026\020\024\023\030\017\016\021\027\ \t\n \235\026\022\021\024\030\024\n \007\035\016 \023\030\017\032\017\r\035\ \036\027\017\016 )Tj 0 Tw 0 -1.218 TD (\035\024\f\022\031\021\026.)Tj 0.28 Tw 0 -1.218 TD (\210\002\024\002\013\026\016 \023\024\035\031\004\036\027\027\t\036 \027\ \026\n\017 \007\026\027\027\t\036, \n\024\032\027\024 \026\022\035\033)Tj 0 Tw (-)Tj 0.05 Tw 0 -1.218 TD (\004\017\021\034, \004\021\024 ICG-\026\027\020\017\024\020\030\026\235\017\ \016 \023\030\036\007\f\021\026\r\035\016\036\021 \f\024\002\024\005 \022\ \030\026\005)Tj 0 Tw (-)Tj 0.219 Tw T* (\027\036 \023\036\030\f\023\036\022\021\017\r\027\t\005 \n\036\021\024\007\ \r)Tj /Span<>> BDC ( )Tj EMC (\b\017\030\031\030\020\017\004\036\f\022\024\n \035\036\004\036\027\017\017\ )Tj 0.088 Tw T* (\f\035\024\032\027\t\b \023\030\016\n\024\022\017\001\036\004\027\t\b \f\ \r\017\013\036\005, \021\026\022 \022\026\022 \023\024\r\024\035\016\036\ \021 )Tj 0.046 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\017\027\021\030\026\024\023\036\030\026\006\017\024\027\027\t\b \031\f\035\ \024\r\017\016\b \r\017\031\026\035\017\017\030\024\r\026\021\034 \026\ \030)Tj 0 Tw (-)Tj 0.097 Tw T* (\021\036\030\017\026\035\034\027\t\036 \f\024\f\031\007\t \023\030\016\n\ \024\005 \022\017\001\022\017, \004\021\024 \f\023\024\f\024\002\f\021\r\ \031\036\021 )Tj 0.072 Tw T* (\r\t\002\024\030\031 \020\030\026\027\017\006 \031\004\026\f\021\022\026\ \023\030\016\n\024\005 \022\017\001\022\017 \007\035\016 \235\024\030\n\ \017\030\024)Tj 0 Tw (-)Tj -0.034 Tw T* (\r\026\027\017\016 \023\024\035\027\024\f\035\024\005\027\024\020\024 \035\ \024\f\022\031\021\026 \f)Tj /Span<>> BDC ( )Tj EMC (\023\024\f\035\036\007\031\033\013\036\005 \023\035\026\f\021\017)Tj 0 Tw (-)Tj 0.089 Tw T* (\022\024\005 \r\027\031\021\030\036\027\027\036\020\024 \f\r\017\013\036\ \r\024\020\024 \024\021\r\036\030\f\021\017\016 \f)Tj /Span<>> BDC ( )Tj EMC (\026\007\036\022\r\026\021\027\t\n )Tj 0.232 Tw T* (\022\030\024\r\024\f\027\026\002\032\036\027\017\036\n \r)Tj /Span<>> BDC ( )Tj EMC (\006\036\035\016\b \023\030\024\235\017\035\026\022\021\017\022\017 \024\ \f\035\024\032\027\036)Tj 0 Tw (-)Tj 0.084 Tw T* (\027\017\005 \r)Tj /Span<>> BDC ( )Tj EMC (\023\024\f\035\036\024\023\036\030\026\006\017\024\027\027\024\n \023\036\ \030\017\024\007\036, \f\r\016\026\027\027\t\b \f)Tj /Span<>> BDC ( )Tj EMC (\027\036)Tj 0 Tw (-)Tj T* (\007\024\f\021\026\021\024\004\027\024\f\021\034\033 \022\030\024\r\024\f\ \027\026\002\032\036\027\017\016.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 275.0305 396.0238 Tm (\023\232\023\037\226\232)Tj 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0 Tc -0.021 Tw 10 0 0 10 274.9606 371.6678 Tm (1.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (ICG-\026\027\020\017\024\020\030\026\235\017\016 \n\024\032\036\021 \002\ \t\021\034 \030\036\022\024\n\036\027\007\024\r\026\027\026 \022)Tj /Span<>> BDC ( )Tj EMC (\017\f)Tj 0 Tw (-)Tj 0.244 Tw -1.296 -1.218 Td (\023\024\035\034\024\r\026\027\017\033 \007\035\016 \024\006\036\027\022\ \017 \026\027\020\017\024\026\030\b\017\021\036\022\021\024\027\017\022\017\ \023\030\016)Tj 0 Tw (-)Tj 0.049 Tw T* (\n\024\005 \022\017\001\022\017 \017)Tj /Span<>> BDC ( )Tj EMC (\r\t\002\024\030\026 \020\030\026\027\017\006 \007\035\016 \235\024\030\n\ \017\030\024\r\026\027\017\016 \023\024\035)Tj 0 Tw (-)Tj 0.078 Tw T* (\027\024\f\035\024\005\027\024\020\024 \035\024\f\022\031\021\026 \f)Tj /Span<>> BDC ( )Tj EMC (\026\007\036\022\r\026\021\027\t\n \022\030\024\r\024\f\027\026\002\032\036\ \027\017\036\n )Tj 0 Tw T* (\023\030\017)Tj /Span<>> BDC ( )Tj EMC (\035\036\004\036\027\017\017 \f\035\024\032\027\t\b \023\030\016\n\024\022\ \017\001\036\004\027\t\b \f\r\017\013\036\005.)Tj 0.129 Tw T* (2.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (\215\030\017)Tj /Span<>> BDC ( )Tj EMC (\007\036\021\026\035\034\027\024\n \026\027\026\035\017\036 \b\030\024\027\ \024\n\036\021\030\017\017 \022\030\024\r\024\f\027\026\002)Tj 0 Tw (-)Tj 0.268 Tw -1.296 -1.218 Td (\032\036\027\017\016 \035\024\f\022\031\021\026 \r\t\f\024\021\024\005 \r\ )Tj /Span<>> BDC ( )Tj EMC (1/3 \024\022\030\031\032\027\024\f\021\017 \023\030\016\n\024\005 )Tj 0.182 Tw T* (\022\017\001\022\017 \r)Tj /Span<>> BDC ( )Tj EMC (\031\f\035\024\r\017\016\b \002\024\022\024\r\024\020\024 \006\017\030\022\ \031\035\016\021\024\030\027\024\020\024 \026\030\036\f\021\026 )Tj 0.225 Tw T* (\002\t\035\024 \r\t\016\r\035\036\027\024 \024\021\f\031\021\f\021\r\017\ \036 \027\026\004\017\n\024\005 \030\026\027\017\006\t \r\030\036)Tj 0 Tw (-)Tj 0.284 Tw T* [(\n\036\027\017 \027\026\f\021\031\023\035\036\027\017\016 )0.5(\026\030\021\036\030\017\026\035\034\027\024\005 \235\026\t \027\036\026\ \r\017\f\017\n\024 )]TJ 0.148 Tw T* (\024\021 \001\017\030\017\027\t \035\024\f\022\031\021\026 \023\024)Tj /Span<>> BDC ( )Tj EMC (\f\030\026\r\027\036\027\017\033 \f)Tj /Span<>> BDC ( )Tj EMC (\017\027\021\026\022\021\027\024\005 \023\030\016)Tj 0 Tw (-)Tj 0.228 Tw T* (\n\024\005 \022\017\001\022\024\005, \024\007\027\026\022\024 \023\030\017\ )Tj /Span<>> BDC ( )Tj EMC (\220\021\024\n \r\t\016\r\035\036\027\024 \007\024\f\021\024\r\036\030)Tj 0 Tw (-)Tj 0.147 Tw T* [(\027\024\036 \031\007\035\017\027\036\027\017\036 )0.5(\r\036\027\024\027\024\005 )0.5(\235\026\t )0.5(\023\030\017)]TJ /Span<>> BDC ( )Tj EMC [(\001\017\030\017\027\036 )0.5(\035\024\f\022\031\021\026 )]TJ 0.193 Tw T* (1/4)Tj /Span<>> BDC ( )Tj EMC (\024\022\030\031\032\027\024\f\021\017 \023\030\016\n\024\005 \022\017\001\ \022\017, \f\r\017\007\036\021\036\035\034\f\021\r\031\033\013\036\036 )Tj 0.141 Tw T* (\024\002 \031\b\031\007\001\036\027\017\017 \022\030\024\r\024\f\027\026\ \002\032\036\027\017\016 \r)Tj /Span<>> BDC ( )Tj EMC (\f\r\016\017 \f)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\036\f\036\004\036)Tj 0 Tw (-)Tj T* (\027\017\036\n \r\036\027\024\027\t\b \022\024\035\035\026\021\036\030\026\ \035\036\005.)Tj 0.124 Tw T* (3.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (\200)Tj /Span<>> BDC ( )Tj EMC (\f\r\016\017 \f)Tj /Span<>> BDC ( )Tj EMC (\023\024\035\031\004\036\027\027\t\n\017 \007\026\027\027\t\n\017, \006\036\ \035\036\f\024\024\002\030\026\027\024 )Tj 1.242 Tw -1.296 -1.218 Td (\r\t\007\036\035\036\027\017\036 \023\024\035\027\024\f\035\024\005\027\024\ \020\024 \035\024\f\022\031\021\026 \001\017\030\017\027\024\005 )Tj 0.046 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (1/3)Tj /Span<>> BDC ( )Tj EMC (\024\022\030\031\032\027\024\f\021\017 \023\030\016\n\024\005 \022\017\001\ \022\017 \f)Tj /Span<>> BDC ( )Tj EMC (\006\036\027\021\030\026\035\034\027\t\n \030\026\f)Tj 0 Tw (-)Tj 0.164 Tw T* [(\023\024\035\024\032\036\027\017\036\n )0.5(\f\024\f\031\007\026 \031)]TJ /Span<>> BDC ( )Tj EMC [(\023\026\006\017\036\027\021\024\r )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC 15.132 0 Td (3-\n\016 \007\017\f\021\026\035\034\027\t)Tj 0 Tw (-)Tj 0.133 Tw -15.132 -1.218 Td (\n\017 \r\036\021\r\016\n\017 \023\030\016\n\024\022\017\001\036\004\027\ \t\b \026\030\021\036\030\017\005, \026)Tj /Span<>> BDC ( )Tj EMC (\031 \023\026\006\017\036\027\021\024\r )Tj 0.142 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (4-\n\016 \017)Tj /Span<>> BDC ( )Tj EMC (5-\033 \007\017\f\021\026\035\034\027\t\n\017 \r\036\021\r\016\n\017 \023\ \030\016\n\024\022\017\001\036\004\027\t\b )Tj 0.027 Tw T* (\026\030\021\036\030\017\005)Tj /Span<>> BDC ( )Tj EMC (\227 \f)Tj /Span<>> BDC ( )Tj EMC (\022\030\026\036\r\t\n \030\026\f\023\024\035\024\032\036\027\017\036\n \ 2-\b \002\035\017\035\036\032\026)Tj 0 Tw (-)Tj 0.04 Tw T* [(\013\017\b )0.5(\f\024\f\031\007\024\r \r)]TJ /Span<>> BDC ( )Tj EMC [(\035\024\f\022\031\021\036, )0.5(\004\021\024 \f\024\023\030\024\r\024\032\007\026\036\021\f\016 )0.5(\031\007\024\r\035\036\021)]TJ 0 Tw (-)Tj T* (\r\024\030\017\021\036\035\034\027\t\n \022\030\024\r\024\f\027\026\002\032\ \036\027\017\036\n \035\024\f\022\031\021\026.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\033\030\031\030\213\b)-20.9(\035\231\213\233\t \021\032)50(\b)42(\032\231\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj /T1_4 1 Tf 25 0 0 25 512.9018 56.0378 Tm (97)Tj ET endstream endobj 1493 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.185 Tw 10 0 0 10 70.8661 517.8039 Tm (\235\035\033\024\030\036\f\006\036\027\006\017\017 \017\027\021\026\022\021\ \027\024\005 \022\017\001\022\017 \017)Tj /Span<>> BDC ( )Tj EMC (\023\024\035\027\024\f\035\024\005\027\024\020\024 )Tj 0.125 Tw 0 -1.218 TD (\023\030\016\n\024\022\017\001\036\004\027\024\020\024 \035\024\f\022\031\ \021\026 \r)Tj /Span<>> BDC ( )Tj EMC (\031\f\035\024\r\017\016\b \f\n\024\007\036\035\017\030\024\r\026\027)Tj 0 Tw (-)Tj 0.04 Tw T* (\027\024\020\024 \002\024\022\024\r\024\020\024 \006\017\030\022\031\035\ \016\021\024\030\027\024\020\024 \026\030\036\f\021\026. \200\030\036\n\016\ \027\026\004\026\035\026 )Tj 0.597 Tw T* [(\026\030\021\036\030\017\026\035\034\027\024\005 )0.6(\235\026\t, )0.5(\b\026\030\026\022\021\036\030\017\031\033\013\036\036 )0.6(\017\027\021\036\027\f\017\r)]TJ 0 Tw (-)Tj 0.317 Tw T* (\027\024\f\021\034 \026\030\021\036\030\017\026\035\034\027\024\020\024 \ \022\030\024\r\024\f\027\026\002\032\036\027\017\016, \002\t\035\024 \f\024\ \023\024)Tj 0 Tw (-)Tj -0.025 Tw T* [(\f\021\026\r\017\n\024 )0.5(\r\024 \r\f\036\b \020\030\031\023\023\026\b )0.5(\027\036\026\r\017\f\017\n\024 )0.5(\024\021 \024\f\024\002\036\027\027\024\f\021\036\005 )]TJ 0.052 Tw T* [(\026\027\020\017\024\026\030\b\017\021\036\022\021\024\027\017\022\017 )0.5(\023\030\016\n\024\005 \022\017\001\022\017. \230\026\022\032\036 \r\t\016\ \r\035\036\027\024 )]TJ 0.333 Tw T* (\024\021\f\031\021\f\021\r\017\036 \027\026\004\017\n\024\005 \030\026\ \027\017\006\t \026\030\021\036\030\017\026\035\034\027\024\020\024 \022\ \030\024)Tj 0 Tw (-)Tj 0.048 Tw T* [(\r\024\f\027\026\002\032\036\027\017\016 )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC 6.596 0 Td [(\035\024\f\022\031\021\024\r )0.5(\030\026\035\017\004\027\024\005 )0.5(\001\017\030\017\027\t. )0.6(\210\007\027\026\022\024 )]TJ 0.061 Tw -6.596 -1.218 Td (\r\t\016\r\035\036\027\t \f\035\036\007\031\033\013\017\036 \017\n\036\027\ \036\027\017\016 \r)Tj /Span<>> BDC ( )Tj EMC (\r\036\027\024\027\024\n \024\021\021\024\022\036: )Tj -0.047 Tw T* (\023\030\017)Tj /Span<>> BDC ( )Tj EMC (\001\017\030\017\027\036 \023\024\035\027\024\f\035\024\005\027\024\020\024\ \035\024\f\022\031\021\026 \r)Tj /Span<>> BDC ( )Tj EMC (1/3 \024\022\030\031\032\027\024\f\021\017 )Tj 0.044 Tw T* (\023\030\016\n\024\005 \022\017\001\022\017 \027\026\002\035\033\007\026\ \035\024\f\034 \027\036\027\026\004\017\021\036\035\034\027\024\036 \031\ \007\035\017\027\036)Tj 0 Tw (-)Tj 0.204 Tw T* [(\027\017\036 )0.5(\r\036\027\024\027\024\020\024 )0.6(\024\021\021\024\022\026, )0.5(\r\t\030\026\032\026\033\013\036\036\f\016 )0.6(\r)]TJ /Span<>> BDC ( )Tj EMC 17.652 0 Td (\031\007\035\017\027\036\027\017\017 )Tj 0.16 Tw -17.652 -1.218 Td (\f\030\036\007\027\036\020\024 \r\030\036\n\036\027\017 \027\026\f\021\031\ \023\035\036\027\017\016 \235\026\t \n\026\022\f\017\n\026\035\034\027\024\ \005 )Tj 0.011 Tw T* (\235\035\033\024\030\036\f\006\036\027\006\017\017 \007\024)Tj /Span<>> BDC ( )Tj EMC (61,5 \f. \023\024)Tj /Span<>> BDC ( )Tj EMC (\f\030\026\r\027\036\027\017\033 \f)Tj /Span<>> BDC ( )Tj EMC (\017\027\021\026\022\021\027\024\005 )Tj 0.042 Tw T* (\022\017\001\022\024\005 \(58,2 \f.\), \026)Tj /Span<>> BDC ( )Tj EMC (\023\030\017 \001\017\030\017\027\036 \035\024\f\022\031\021\026 \r)Tj /Span<>> BDC ( )Tj EMC (1/4)Tj /Span<>> BDC ( )Tj EMC (\024\022\030\031\032)Tj 0 Tw (-)Tj -0.065 Tw T* (\027\024\f\021\017)Tj /Span<>> BDC ( )Tj EMC (\227 \r)Tj /Span<>> BDC ( )Tj EMC (\007\024\f\021\024\r\036\030\027\024\n \()Tj /T1_1 1 Tf 0 Tw (p)Tj /T1_0 1 Tf -0.065 Tw /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (0,05\) \031\007\035\017\027\036\027\017\017 \f\030\036\007\027\036\020\024\ )Tj 0.136 Tw T* (\r\030\036\n\036\027\017 \027\026\f\021\031\023\035\036\027\017\016 \235\ \026\t \n\026\022\f\017\n\026\035\034\027\024\005 \235\035\031\024\030\036\ \f)Tj 0 Tw (-)Tj 0.098 Tw T* [(\006\036\027\006\017\017 )0.5(\007\024)]TJ /Span<>> BDC ( )Tj EMC 4.686 0 Td [(77,6 )0.5(\f., \021\024 )0.5(\036\f\021\034 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 7.334 0 Td [(1,26 )0.5(\030\026\026 \023\024)]TJ /Span<>> BDC ( )Tj EMC 5.533 0 Td (\f\030\026\r\027\036\027\017\033 )Tj 0.063 Tw -17.552 -1.218 Td (\f)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\024\r\t\n \023\024\022\026\026\021\036\035\036\n \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\001\017\030\017\027\024\005 \235\024\030)Tj 0 Tw (-)Tj T* (\n\017\030\031\036\n\024\020\024 \035\024\f\022\031\021\026 \r)Tj /Span<>> BDC ( )Tj EMC (1/3)Tj /Span<>> BDC ( )Tj EMC (\024\022\030\031\032\027\024\f\021\017 \023\030\016\n\024\005 \022\017\001\ \022\017.)Tj 0.187 Tw T* (\211 \r\f\036\b \023\026\006\017\036\027\021\024\r \017\027\021\030\026-\ \017)Tj /Span<>> BDC ( )Tj EMC (\023\024\f\035\036\024\023\036\030\026\006\017\024\027\027\t\b \024\f)Tj 0 Tw (-)Tj -0.02 Tw T* (\035\024\032\027\036\027\017\005 \027\036 \027\026\002\035\033\007\026\035\ \024\f\034, \017)Tj /Span<>> BDC ( )Tj EMC (\002\t\035\024 \024\021\n\036\004\036\027\024 \031\007\024\r\035\036\021\ )Tj 0 Tw (-)Tj T* (\r\024\030\017\021\036\035\034\027\024\036 \023\030\017\032\017\r\035\036\ \027\017\036 \035\024\f\022\031\021\026.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 70.936 201.1759 Tm [(\037\036)10(\032\223\212\226\034\022\031\034)]TJ 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0 Tc 0.535 Tw 10 0 0 10 70.8661 176.8199 Tm (\203\036\f\n\024\021\030\016 \027\026)Tj /Span<>> BDC ( )Tj EMC (\027\026\004\017\021\036\035\034\027\024\036 \004\017\f\035\024 \b\017\030\ \031\030\020\017\004\036\f\022\017\b )Tj 0.282 Tw T* (\n\036\021\024\007\017\022 \017)Tj /Span<>> BDC ( )Tj EMC (\017\b \n\024\007\017\235\017\022\026\006\017\005, \027\026\023\030\026\r\ \035\036\027\027\t\b \027\026)Tj /Span<>> BDC ( )Tj EMC (\b\017)Tj 0 Tw (-)Tj 0.973 Tw T* (\030\031\030\020\017\004\036\f\022\024\036 \035\036\004\036\027\017\036 \ \023\030\016\n\024\022\017\001\036\004\027\t\b \f\r\017\013\036\005, )Tj 0.186 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC (\f\036\020\024\007\027\016\001\027\017\005 \007\036\027\034, \007\024\022\ \026\026\021\036\035\034\f\021\r\026 \027\036\024\f\023\024\030\017\n\t\ \b )Tj 0.441 Tw T* (\023\030\036\017\n\031\013\036\f\021\r \022\026\022\024\005-\035\017\002\ \024 \017)Tj /Span<>> BDC ( )Tj EMC (\027\017\b \017, \f\035\036\007\024\r\026\021\036\035\034)Tj 0 Tw (-)Tj 0.222 Tw T* (\027\024, \253\031\027\017\r\036\030\f\026\035\034\027\t\005\273 \023\024\ \007\b\024\007 \022)Tj /Span<>> BDC ( )Tj EMC (\035\036\004\036\027\017\033 \023\026\006\017\036\027\021\024\r )Tj 0.106 Tw T* (\007\026\027\027\024\020\024 \023\030\024\235\017\035\016 \024\021\f\031\ \021\f\021\r\031\033\021, \026)Tj /Span<>> BDC ( )Tj EMC (\030\017\f\022\017 \030\026\r\017\021\017\016 \030\036)Tj 0 Tw (-)Tj 0.139 Tw T* [(\006\017\007\017\r\024\r \026\002\024\035\036\r\026\027\017\016 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC [(\023\024\f\035\036\024\023\036\030\026\006\017\024\027\027\t\b )0.5(\024\f\035\024\032)]TJ 0 Tw (-)Tj 0.106 Tw T* (\027\036\027\017\005 \024\f\021\026\033\021\f\016 \027\026)Tj /Span<>> BDC ( )Tj EMC (\r\t\f\024\022\024\n \031\030\024\r\027\036. \230\026\022, \023\024)Tj /Span<>> BDC ( )Tj EMC (\007\026\027\027\t\n )Tj 0.022 Tw 23.244 43.841 Td (\030\026\035\017\004\027\t\b \017\f\f\035\036\007\024\r\026\027\017\005\ \017)Tj /Span<>> BDC ( )Tj EMC (\n\036\021\026\026\027\026\035\017\024\r, \f\031\n\n\026\030\027\026\016\ )Tj -0.039 Tw T* (\004\026\f\021\024\021\026 \030\036\006\017\007\017\r\024\r \023\030\016\ \n\024\022\017\001\036\004\027\t\b \f\r\017\013\036\005 \f\024\f\021\026\ \r\035\016)Tj 0 Tw (-)Tj T* (\036\021, \022\026\022 \n\017\027\017\n\031\n, 20% [4,7,17\22620].)Tj 0.248 Tw T* (\200 \f\r\016\017 \f)Tj /Span<>> BDC ( )Tj EMC (\220\021\017\n \023\030\024\002\035\036\n\026 \035\036\004\036\027\017\016\ \f\r\017\013\036\005 \023\030\016\n\024\005 )Tj 0.13 Tw T* (\022\017\001\022\017 \002\t\035\026 \017)Tj /Span<>> BDC ( )Tj EMC (\007\024 \f\017\b \023\024\030 \024\f\021\026\036\021\f\016 \027\036\030\ \036\001\036\027\027\024\005 \007\035\016 )Tj 0.088 Tw T* (\b\017\030\031\030\020\017\004\036\f\022\024\005 \022\024\035\024\023\030\ \024\022\021\024\035\024\020\017\017. \210\f\024\002\036\027\027\024 \007\ \017\f\022\031\021\026)Tj 0 Tw (-)Tj 0.056 Tw T* (\002\036\035\034\027\t\n \016\r\035\016\036\021\f\016 \r\024\023\030\024\ \f \r\t\002\024\030\026 \021\036\b\027\017\022\017 \024\023\036\030\026\021\ \017\r)Tj 0 Tw (-)Tj 0.006 Tw T* (\027\024\020\024 \r\n\036\001\026\021\036\035\034\f\021\r\026 \023\030\017\ )Tj /Span<>> BDC ( )Tj EMC (\022\024\030\030\036\022\006\017\017 \f\035\024\032\027\t\b \f\r\017\013\ \036\005, )Tj -0.015 Tw T* [(\026\b\r\026\021\t\r\026\033\013\017\b )0.5(\002\024\035\036\036 1/3\2261/2 \027\026\030\031\032\027\024\020\024 \f\235\ \017\027\022\021\036\030\026 )]TJ -0.043 Tw T* (\017\035\017 \030\026\f\023\024\035\024\032\036\027\027\t\b \220\022\f\021\ \030\026\f\235\017\027\022\021\036\030\027\024, \f\024\023\030\016\032\036\ \027\027\t\b )Tj 0.107 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\r\t\f\024\022\017\n \030\017\f\022\024\n \030\026\r\017\021\017\016 \027\ \036\007\024\f\021\026\021\024\004\027\024\f\021\017 \026\027\026\035\034\ )Tj 0 Tw (-)Tj 0.002 Tw T* (\027\024\020\024 \f\235\017\027\022\021\036\030\026 \017)Tj /Span<>> BDC ( )Tj EMC (\030\036\006\017\007\017\r\026 \026\002\024\035\036\r\026\027\017\016 \r\ )Tj /Span<>> BDC ( )Tj EMC (\023\024\f\035\036\024\023\036)Tj 0 Tw (-)Tj T* (\030\026\006\017\024\027\027\024\n \023\036\030\017\024\007\036.)Tj 0.087 Tw T* (\253\207\026\024\r\t\n\273, \001\017\030\024\022\024 \023\030\017\n\036\ \027\016\036\n\t\n \017)Tj /Span<>> BDC ( )Tj EMC (\030\036\022\024\n\036\027\007\031\036\n\t\n )Tj 0.409 Tw T* (\n\036\021\024\007\024\n \b\017\030\031\030\020\017\004\036\f\022\024\005\ \022\024\030\030\036\022\006\017\017 \f\035\024\032\027\t\b \023\030\016\ )Tj 0 Tw (-)Tj 0.208 Tw T* [(\n\024\022\017\001\036\004\027\t\b )0.5(\f\r\017\013\036\005 \016\r\035\016\036\021\f\016 )0.5(\017\b \017\f\f\036\004\036\027\017\036 )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC (\027\017)Tj 0 Tw (-)Tj 0.27 Tw T* (\r\036\007\036\027\017\036\n \035\024\f\022\031\021\026 \023\030\016\n\024\ \005 \022\017\001\022\017, \024\002\036\f\023\036\004\017\r\026\033\013\036\ \036 )Tj 0.045 Tw T* [(\220\235\235\036\022\021\017\r\027\024\f\021\034 )0.5(\007\024)]TJ /Span<>> BDC ( )Tj EMC (87% \027\026)Tj /Span<>> BDC ( )Tj EMC 11.182 0 Td [(\235\024\027\036 \004\026\f\021\024\021\t )0.5(\026\032\017\r\035\036\027\017\016 )]TJ 0.136 Tw -11.182 -1.218 Td (\f\r\017\013\026 \f)Tj /Span<>> BDC ( )Tj EMC (\030\031\002\006\024\r\t\n\017 \017\n\036\027\036\027\017\016\n\017 \026\ \027\026\035\034\027\024\020\024 \022\026\027\026\035\026 )Tj 0.208 Tw T* (\024\022\024\035\024 58,3%, \030\017\f\022\026 \030\036\006\017\007\017\r\ \026)Tj /Span<>> BDC ( )Tj EMC (\227 \007\024)Tj /Span<>> BDC ( )Tj EMC (7,5%, \026)Tj /Span<>> BDC ( )Tj EMC (\004\026\f\021\024)Tj 0 Tw (-)Tj 0.103 Tw T* [(\021\t \026\027\026\035\034\027\024\005 )0.5(\017\027\022\024\027\021\017\027\036\027\006\017\017)]TJ /Span<>> BDC ( )Tj EMC 12.316 0 Td (\227 \r)Tj /Span<>> BDC ( )Tj EMC [(\023\030\036\007\036\035\026\b )0.5(7\22620,4% )]TJ 0.126 Tw -12.316 -1.218 Td [([4,16,17,19]. )0.5(\224\021\017 \024\023\036\030\026\006\017\017 )0.5(\n\024\032\027\024 \024\021\027\036\f\021\017 )0.5(\022)]TJ /Span<>> BDC ( )Tj EMC (\023\035\026\f\021\017)Tj 0 Tw (-)Tj -0.007 Tw T* (\004\036\f\022\017\n \n\036\021\024\007\026\n, \022)Tj /Span<>> BDC ( )Tj EMC (\023\030\036\017\n\031\013\036\f\021\r\026\n \022\024\021\024\030\t\b \024\ \021\027\024\f\016\021\f\016 )Tj 0.198 Tw T* [(\r\t\f\024\022\026\016 \220\235\235\036\022\021\017\r\027\024\f\021\034,\ )0.5(\027\017\022\017\005 \030\017\f\022 \023\024\r\030\036\032\007\036\027\017\ \016 )]TJ 0.136 Tw T* (\026\023\017\030\026\021\036\035\034\027\024\020\024 \026\023\023\026\030\ \026\021\026, \n\017\027\017\n\026\035\034\027\t\005 \030\017\f\022 \017\ \027\235\017)Tj 0 Tw (-)Tj 0.138 Tw T* (\006\017\030\024\r\026\027\017\016 \024\022\024\035\024\023\030\016\n\024\ \022\017\001\036\004\027\024\005 \022\035\036\021\004\026\021\022\017 \017\ )Tj /Span<>> BDC ( )Tj EMC (\n\017\027\017)Tj 0 Tw (-)Tj 0.084 Tw T* (\n\026\035\034\027\t\036 \f\030\024\022\017 \026\032\017\r\035\036\027\017\ \016 \023\024\f\035\036\024\023\036\030\026\006\017\024\027\027\t\b \030\ \026\027 )Tj 0.056 Tw T* (\017, \f\024\024\021\r\036\021\f\021\r\036\027\027\024, \022\024\030\024\ \021\022\017\036 \f\030\024\022\017 \030\036\026\002\017\035\017\021\026\ \006\017\017 \023\026)Tj 0 Tw (-)Tj T* (\006\017\036\027\021\024\r \023\024\f\035\036 \b\017\030\031\030\020\017\ \004\036\f\022\024\020\024 \r\n\036\001\026\021\036\035\034\f\021\r\026 \ [21].)Tj -0.01 Tc 0.309 Tw T* (\215\030\017 \r\t\023\024\035\027\036\027\017\017 \021\026\022\017\b \024\ \023\036\030\026\006\017\005 \027\036\024\002\b\024\007\017\n\024 \023\030\ \017)Tj 0 Tc 0 Tw (-)Tj -0.01 Tc 0.305 Tw T* (\007\036\030\032\017\r\026\021\034\f\016 \022\026\027\024\027\024\r \002\ \036\024\023\026\f\027\024\005 \030\036\022\024\027\f\021\030\031\022\021\ \017\r\027\024-)Tj 0.381 Tw T* (\023\035\026\f\021\017\004\036\f\022\024\005 \b\017\030\031\030\020\017\017\ , \026)Tj /Span<>> BDC ( )Tj EMC (\017\n\036\027\027\024)Tj /Span<>> BDC ( )Tj EMC [(\227 \024\002\036\f\023\036\004\036\027\017\036)-10( )]TJ 0.137 Tw T* [(\026\007\036\022\r\026\021\027\024\020\024 \022\030\024\r\024\f\027\026\002\ \032\036\027\017\016 \035\024\f\022\031\021\026 \023\030\016\n\024\005 \022\ \017\001\022\017,)-10( )]TJ 0.224 Tw T* (\024\021\f\031\021\f\021\r\017\036 \027\026\021\016\032\036\027\017\016 \ \021\022\026\027\036\005, \024\023\021\017\n\026\035\034\027\024\020\024\ \f\024\024\021\027\024)Tj 0 Tc 0 Tw (-)Tj -0.01 Tc 0.193 Tw T* (\001\036\027\017\036 \001\017\030\017\027\t \017)Tj /Span<>> BDC ( )Tj EMC (\r\t\f\024\021\t \035\024\f\022\031\021\026, \024\021\f\031\021\f\021\r\017\ \036 \253\n\036\030\021)Tj 0 Tc 0 Tw (-)Tj -0.01 Tc 0.21 Tw T* (\r\t\b\273 \023\030\024\f\021\030\026\027\f\021\r \017)Tj /Span<>> BDC ( )Tj EMC [(\023\030\026\r\017\035\034\027\024\036 \023\024\f\035\036\024\023\036\030\ \026\006\017\024\027\027\024\036)-9.9( )]TJ 0.297 Tw T* [(\r\036\007\036\027\017\036 )0.5(\023\026\006\017\036\027\021\026. )0.5(\221\035\036\007\031\036\021 )0.5(\023\024\007\004\036\030\022\027\031\021\034, )0.5(\004\021\024 \024\007\027\024\005)-10( )]TJ 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0 Tc 0.044 Tw 9 0 0 9 70.8661 730.483 Tm [(\020\004\206\f\t\204\004 )0.5(1.)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf [( \212\031\016\205\023\022\024\026\024\020 )0.5(\004\032\n\021\n\003\031\024\032\025\025 )0.5(\013\032\n\027\n\t\021\026\005\204\031\021\025\002 )0.5(\025\021\024\026\013\024\021\n\017 )0.6(\033\032\002\003\n\017 \013\025\001\013\025 )0.5(\025)]TJ /Span<>> BDC ( )Tj EMC 35.493 0 Td (\033\n\023\021\n\t\023\n\017\021\n\202\n \033\032\002\003\n\013\025\001\031\ \006\021\n\202\n \023\n)Tj 0 Tw (-)Tj -35.493 -1.2 Td (\t\013\205\024\026 \033\n)Tj /Span<>> BDC ( )Tj EMC (\030\026\021\021\020\003 ICG-\026\021\202\025\n\202\032\026\f\025\025)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0 -1.2 TD [(T)48(able 1)47(.)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf [( R)21.1(esults of intact rectum\242)37.2(s and full-thickness rectal \234ap\242)37.2(s chronometr)-43(y of blood supply according to ICG-angiog)14(raph)12(y)]TJ ET 0 0 0 1 K 0.5 w /GS2 gs q 1 0 0 1 70.8661 704.381 cm 0 0 m 110.801 0 l S Q q 1 0 0 1 71.1161 683.3118 cm 0 0 m 0 20.819 l S Q q 1 0 0 1 181.6673 704.381 cm 0 0 m 53.858 0 l S Q q 1 0 0 1 181.6673 683.5618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 235.5256 704.381 cm 0 0 m 53.858 0 l S Q q 1 0 0 1 289.3839 704.381 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 331.9036 704.381 cm 0 0 m 96.378 0 l S Q q 1 0 0 1 331.9036 683.5618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 428.2815 704.381 cm 0 0 m 96.628 0 l S Q q 1 0 0 1 524.6594 683.5618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 71.1161 624.0925 cm 0 0 m 0 59.219 l S Q q 1 0 0 1 181.4173 683.3118 cm 0 0 m 54.108 0 l S Q q 1 0 0 1 181.6673 624.0925 cm 0 0 m 0 58.969 l S Q q 1 0 0 1 235.5256 683.3118 cm 0 0 m 53.858 0 l S Q q 1 0 0 1 235.5256 624.0925 cm 0 0 m 0 58.969 l S Q q 1 0 0 1 289.3839 683.3118 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 289.3839 624.0925 cm 0 0 m 0 58.969 l S Q q 1 0 0 1 331.9036 683.3118 cm 0 0 m 96.378 0 l S Q q 1 0 0 1 331.9036 624.0925 cm 0 0 m 0 58.969 l S Q q 1 0 0 1 428.2815 683.3118 cm 0 0 m 96.628 0 l S Q q 1 0 0 1 428.2815 624.0925 cm 0 0 m 0 58.969 l S Q q 1 0 0 1 524.6594 624.0925 cm 0 0 m 0 58.969 l S Q q 1 0 0 1 70.8661 623.8425 cm 0 0 m 110.801 0 l S Q q 1 0 0 1 71.1161 612.6313 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 181.6673 623.8425 cm 0 0 m 53.858 0 l S Q q 1 0 0 1 181.6673 612.6313 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 235.5256 623.8425 cm 0 0 m 53.858 0 l S Q q 1 0 0 1 235.5256 612.6313 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 289.3839 623.8425 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 289.3839 612.6313 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 331.9036 623.8425 cm 0 0 m 96.378 0 l S Q q 1 0 0 1 331.9036 612.6313 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 428.2815 623.8425 cm 0 0 m 96.628 0 l S Q q 1 0 0 1 428.2815 612.6313 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 612.6313 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 612.3813 cm 0 0 m 110.801 0 l S Q q 1 0 0 1 71.1161 572.37 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 181.6673 612.3813 cm 0 0 m 53.858 0 l S Q q 1 0 0 1 181.6673 572.37 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 235.5256 612.3813 cm 0 0 m 53.858 0 l S Q q 1 0 0 1 235.5256 572.37 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 289.3839 612.3813 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 289.3839 572.37 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 331.9036 612.3813 cm 0 0 m 96.378 0 l S Q q 1 0 0 1 331.9036 572.37 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 428.2815 612.3813 cm 0 0 m 96.628 0 l S Q q 1 0 0 1 428.2815 572.37 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 524.6594 572.37 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 70.8661 572.12 cm 0 0 m 110.801 0 l S Q q 1 0 0 1 181.6673 572.12 cm 0 0 m 53.858 0 l S Q q 1 0 0 1 235.5256 572.12 cm 0 0 m 53.858 0 l S Q q 1 0 0 1 289.3839 572.12 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 331.9036 572.12 cm 0 0 m 96.378 0 l S Q q 1 0 0 1 428.2815 572.12 cm 0 0 m 96.628 0 l S Q BT /GS1 gs /T1_3 1 Tf 8 0 0 8 117.9039 661.2118 Tm (\203\004\213\004)Tj 9.512 4.317 Td (\200\002\220\004\213\004\003\r\f\001 \216\006\002\b\002\214\r\003\006\t\t\ \t\b\003\004\220\003\b\002\005 )Tj 4.657 -1.2 Td (\212\006\235\214\002\005 \220\t\230\220\t)Tj 15.695 1.2 Td (\200\002\220\004\213\004\003\r\f\001 \216\006\002\b\002\214\r\003\006\t\t\ \212\002\f\b\002\217\f\002\005\b\002\n\002 )Tj 3.389 -1.2 Td (\212\006\235\214\002\220\t\230\r\201\b\002\n\002 \f\002\217\220\210\003\004\ )Tj -23.798 -3.834 Td (1 \n\006\210\212\212\004)Tj 0.389 -1.2 Td (\()Tj /T1_4 1 Tf (n)Tj /T1_3 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (6\))Tj 6.344 1.2 Td (2 \n\006\210\212\212\004)Tj 0.389 -1.2 Td (\()Tj /T1_4 1 Tf (n)Tj /T1_3 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (2\))Tj 5.635 1.2 Td (3 \n\006\210\212\212\004)Tj 0.388 -1.2 Td (\()Tj /T1_4 1 Tf (n)Tj /T1_3 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (1\))Tj 5.318 3.6 Td (\200\002\f\b\002\217\f\002\005\b\013\005 \f\002\217\220\210\003 )Tj 1.463 -1.2 Td (\006\004\213\214\r\006\002\214 )Tj /Span<>> BDC ( )Tj EMC (1/3 )Tj -0.969 -1.2 Td (\002\220\006\210\202\b\002\217\003\t \212\006\235\214\002\005 )Tj 0.423 -1.2 Td (\220\t\230\220\t )Tj /Span<>> BDC ( )Tj EMC (\210\217\f\002\t\235\216 )Tj -0.022 Tw -1.731 -1.2 Td (\206\002\220\002\002\n\002 \204\t\006\220\210\f\235\003\002\006\b\002\n\ \002 )Tj 0 Tw 2.639 -1.2 Td (\004\006\r\217\003\004 \()Tj /T1_4 1 Tf (n)Tj /T1_3 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (6\))Tj 10.222 6 Td (\200\002\f\b\002\217\f\002\005\b\013\005 \f\002\217\220\210\003 )Tj 1.463 -1.2 Td (\006\004\213\214\r\006\002\214 )Tj /Span<>> BDC ( )Tj EMC (1/4 )Tj -0.969 -1.2 Td (\002\220\006\210\202\b\002\217\003\t \212\006\235\214\002\005 )Tj 0.424 -1.2 Td (\220\t\230\220\t )Tj /Span<>> BDC ( )Tj EMC (\210\217\f\002\t\235\216 )Tj -0.022 Tw -1.731 -1.2 Td (\206\002\220\002\002\n\002 \204\t\006\220\210\f\235\003\002\006\b\002\n\ \002 )Tj 0 Tw 2.639 -1.2 Td (\004\006\r\217\003\004 \()Tj /T1_4 1 Tf (n)Tj /T1_3 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (3\))Tj /T1_0 1 Tf -47.285 -1.433 Td (\202\030\021\036\030\017\026\035\034\027\026\016 \235\026\026, \f)Tj 14.224 0 Td (31\22641)Tj /Span<>> BDC ( )Tj EMC (\(34,3\))Tj 7.075 0 Td (32\22634)Tj /Span<>> BDC ( )Tj EMC (\(33\))Tj 7.788 0 Td (35)Tj 6.574 0 Td (33\22636)Tj /Span<>> BDC ( )Tj EMC (\(34,3\))Tj 12.047 0 Td (32\22645)Tj /Span<>> BDC ( )Tj EMC (\(37,6\))Tj -47.708 -1.433 Td (\205\026\026 \n\026\022\f\017\n\026\035\034\027\024\005 )Tj T* (\235\035\033\024\030\036\f\006\036\027\006\017\017 \(\026\030\021\036\030\ \017\026\035\034\027\026\016 )Tj 0 -1.2 TD (\235\026\026 + \027\026\004\026\035\024 \r\036\027\024\027\024\005 \235\ \026\t\), )Tj 0 -1.2 TD (\f\036\022.)Tj 14.224 3.6 Td (49\22668)Tj /Span<>> BDC ( )Tj EMC (\(59,3\))Tj 6.482 0 Td (54\22657)Tj /Span<>> BDC ( )Tj EMC (\(55,5\)*)Tj 8.131 0 Td (57*)Tj 6.324 0 Td (59\22668)Tj /Span<>> BDC ( )Tj EMC (\(61,5\)**)Tj 12.047 0 Td (75\22680)Tj /Span<>> BDC ( )Tj EMC (\(77,6\)**)Tj /T1_1 1 Tf 7 0 0 7 70.8661 560.6354 Tm (\032\025\003\031\006\026\021\025\031: *)Tj /Span<>> BDC ( )Tj EMC [(\227 \t\024\026)49.2(\024\025\t\024\025\006\031\t\013\025 \016\021\026\006\025\003\020\031 \n\ \024)19.2(\023\025\006\025\002 \033\n\013\026\016\026)49.1(\024\031\023\031\017 1 \202\032\205\033\033\020 \033\n)]TJ /Span<>> BDC ( )Tj EMC (\t\032\026\027\021\031\021\025\007 \t)Tj /Span<>> BDC ( )Tj EMC (\026\021\026\023\n\202\025\006\021\020\003\025 \033\026\032\026\003\031\024\ \032\026\003\025 \027\n 2 \025)Tj /Span<>> BDC ( )Tj EMC (3 \202\032\205\033\033\026\004 \033\032\025)Tj /Span<>> BDC ( )Tj EMC (\033\032\n\027\031\030\031\021\025\025 )Tj T* (ICG-\026\021\202\025\n\202\032\026\f\025\025 \025\021\024\026\013\024\021\ \n\017 \033\032\002\003\n\017 \013\025\001\013\025; **)Tj /Span<>> BDC ( )Tj EMC [(\227 \t\024\026)49.4(\024\025\t\024\025\006\031\t\013\025 \016\021\026\006\025\003\020\031 \n\ \024)19.2(\023\025\006\025\002 \033\n\013\026\016\026)49.1(\024\031\023\031\017 \033\032\025)]TJ /Span<>> BDC ( )Tj EMC (\f\n\032\003\025\032\n\027\026\021\025\025 \033\n\023\021\n\t\023\n\017\021\ \n\202\n \023\n\t\013\205\024\026 \032\026\016\003\031\032\n\003 )Tj 0 -1.2 TD (\027)Tj /Span<>> BDC ( )Tj EMC (1/4 \n\013\032\205\204\021\n\t\024\025 \033\032\002\003\n\017 \013\025\001\ \013\025 \033\n)Tj /Span<>> BDC ( )Tj EMC (\t\032\026\027\021\031\021\025\007 \t)Tj /Span<>> BDC ( )Tj EMC (\026\021\026\023\n\202\025\006\021\020\003\025 \033\026\032\026\003\031\024\ \032\026\003\025 \027)Tj /Span<>> BDC ( )Tj EMC [(\202\032\205\033\033\031 \t\032\026\027)0.7(\021\031\021\025\002)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_5 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\033\030\031\030\213\b)-20.9(\035\231\213\233\t \021\032)50(\b)42(\032\231\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj -51.938 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 23, \023\0221)69(, 202)69(4)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 23, \023\0221)69(, 202)69(4)]TJ /T1_6 1 Tf 25 0 0 25 28.1274 56.0378 Tm (96)Tj ET endstream endobj 1483 0 obj <>/ExtGState<>/Font<>/ProcSet[/PDF/Text]/Properties<>/Shading<>/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1484 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1485 0 obj <>/Font<>/ProcSet[/PDF/Text/ImageC]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1486 0 obj <>/Font<>/ProcSet[/PDF/Text/ImageC]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1487 0 obj <>/Font<>/ProcSet[/PDF/Text/ImageC]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1609 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(IC)31(G-\013\001\202\220\025\202\002\013\225\220\205 \r\022\025\227\016\001\n\016\ \n\013\017\016\006)-10(\026\r\013 \225\025\002\024\220\002\025\r\013\001\220\205 )]TJ 0 -1 TD [(\221\025\007\001\025\006)-9.9(\007\025\203\001\025\202)10(\025 \221\002\205\024\025\n\220\016\017\001\025\202)10(\025 \007\025\006\n\215)-19.9(\026)11(\013 \221\002\220\022\025\221\016\002\013\026\220\r\001\025\024 )]TJ T* [(\007\016\017\016\001\220\220 \006)-10(\007\025\217\001\020\207 \221\002\205\024\025\n\220\016\017\001\020\207\ \006\r\220\224\016\203)]TJ 31.181 2 Td [(IC)31(G-angiogr)21.1(aph)31(y for r)31(ectal adv)10(ancement flap in patients with anal f)-21(istulas)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0.023 Tw 10 0 0 10 42.5197 724.8299 Tm (\255\020\032\020\034\255\020\034\030\036\255\021\034\036 \215\036\020\017\ \031\024)Tj /T1_2 1 Tf 0.136 Tw 0 -1.218 TD (\221\021\026\021\017\f\021\017\004\036\f\022\026\016 \024\002\030\026\002\ \024\021\022\026 \023\024\035\031\004\036\027\027\t\b \007\026\027\027\t\ \b \002\t\035\026 )Tj 0.28 Tw T* (\r\t\023\024\035\027\036\027\026 \027\026)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\f\024\027\026\035\034\027\024\n \022\024\n\023\034\033\021\036\ \030\036 \r)Tj /Span<>> BDC ( )Tj EMC (\023\026\022\036\021\036 )Tj 0.117 Tw T* [(\023\030\024\020\030\026\n\n\t S)15(t)15(a)15(t)-32(ist)-32(ica 10.0 \(S)15(t)15(a)15(tsof)-28(t, USA\). \212\035\016 \f\030\026\r)]TJ 0 Tw (-)Tj 0.014 Tw T* (\027\036\027\017\016 \023\024\022\026\026\021\036\035\036\005 \023\030\017\ \n\036\027\016\035\017 \203-\022\030\017\021\036\030\017\005 \025\030\031\ \f\022\026\035\026-)Tj 0.08 Tw T* [(\211\024\035\035\017\f\026. \217\026\035\017\004\017\016 \023\030\017\027\ \026\r\026\035\017\f\034 )0.5(\f\021\026\021\017\f\021\017\004\036\f\022\017 \027\026)]TJ 0 Tw (-)Tj 0 -1.218 TD (\004\017\n\t\n\017 \023\030\017)Tj /Span<>> BDC ( )Tj EMC /T1_3 1 Tf (p)Tj /T1_2 1 Tf /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (0,05.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 42.5896 615.2278 Tm [(\033\034\020)21(\223)50(\r\241)46(\024)52(\026)45(\024\232)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf 0 Tc 0.486 Tw 10 0 0 10 42.5197 590.8718 Tm [(\215\024 )0.5(\007\026\027\027\t\n )0.5(\017\027\021\030\026\024\023\036\030\026\006\017\024\027\027\024\005 )0.5(ICG-\026\027\020\017\024\020\030\026\235\017\017, )]TJ 0.044 Tw 0 -1.218 TD (\007\017\f\021\026\035\034\027\t\036 \r\036\021\r\017 \023\030\016\n\024\ \022\017\001\036\004\027\t\b \026\030\021\036\030\017\005 \002\t\035\017\ \r\t)Tj 0 Tw (-)Tj 0.223 Tw T* (\016\r\035\036\027\t \031)Tj /Span<>> BDC ( )Tj EMC (\r\f\036\b \023\026\006\017\036\027\021\024\r. \025\026\022 \031\032\036\ \002\t\035\024 \024\021\n\036\004\036\027\024 )Tj 0.194 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\030\026\007\036\035\036 \253\215\026\006\017\036\027\021\t \017)Tj /Span<>> BDC ( )Tj EMC (\n\036\021\024\007\t\273, \r)Tj /Span<>> BDC ( )Tj EMC (\026\r\017\f\017\n\024\f\021\017 \024\021 )Tj 0.087 Tw T* (\022\024\035\017\004\036\f\021\r\026 \r\t\016\r\035\036\027\027\t\b \026\ \030\021\036\030\017\005 \r\f\036 \023\026\006\017\036\027\021\t \002\t\035\ \017 )Tj 0.018 Tw T* (\030\026\007\036\035\036\027\t \027\026)Tj /Span<>> BDC ( )Tj EMC (3 \017\f\f\035\036\007\031\036\n\t\036 \020\030\031\023\023\t. \200)Tj /Span<>> BDC ( )Tj EMC (1 \020\030\031\023\023\031 \r\b\024)Tj 0 Tw (-)Tj 0.122 Tw T* (\007\017\035\017 \023\026\006\017\036\027\021\t \f)Tj /Span<>> BDC ( )Tj EMC (3-\n\016 \007\017\f\021\026\035\034\027\t\n\017 \r\036\021\r\016\n\017 \023\ \030\016\n\024)Tj 0 Tw (-)Tj 0.076 Tw T* (\022\017\001\036\004\027\t\b \026\030\021\036\030\017\005, \026)Tj /Span<>> BDC ( )Tj EMC (\r\024 2 \017)Tj /Span<>> BDC ( )Tj EMC (\r 3 \020\030\031\023\023\t)Tj /Span<>> BDC ( )Tj EMC (\227 \023\026\006\017\036\027\021\t )Tj 0.163 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (4 \017)Tj /Span<>> BDC ( )Tj EMC (5 \r\036\021\r\016\n\017, \f\024\024\021\r\036\021\f\021\r\036\027\027\024\ . \211\004\017\021\t\r\026\016 \022\024\035\017\004\036)Tj 0 Tw (-)Tj 0.079 Tw T* (\f\021\r\024 \026\030\021\036\030\017\005, \023\024\035\027\024\f\035\024\ \005\027\t\005 \023\030\016\n\024\022\017\001\036\004\027\t\005 \035\024\ \f\022\031\021 )Tj -0.034 Tw 23.244 24.356 Td (\r\t\007\036\035\016\035\f\016 \001\017\030\017\027\024\005 \017)Tj /Span<>> BDC ( )Tj EMC (\r\t\f\024\021\024\005 \r)Tj /Span<>> BDC ( )Tj EMC (1/3 \024\022\030\031\032\027\024\f\021\017 \023\030\016)Tj 0 Tw (-)Tj 0.009 Tw 0 -1.218 TD (\n\024\005 \022\017\001\022\017 \021\026\022\017\n \024\002\030\026\024\ \n, \004\021\024\002\t \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r 1 \020\030\031\023)Tj 0 Tw (-)Tj 0.077 Tw 0 -1.218 TD (\023\t \f\024\f\031\007 \027\026\b\024\007\017\035\f\016 \r)Tj /Span<>> BDC ( )Tj EMC (\006\036\027\021\030\036 \035\024\f\022\031\021\026, \026)Tj /Span<>> BDC ( )Tj EMC (\031 \023\026\006\017\036\027\021\024\r )Tj -0.036 Tw 0 -1.218 TD (2)Tj /Span<>> BDC ( )Tj EMC (\017)Tj /Span<>> BDC ( )Tj EMC (3 \020\030\031\023\023)Tj /Span<>> BDC ( )Tj EMC (\227 \007\r\026 \002\035\017\035\036\032\026\013\017\b \f\024\f\031\007\ \026 \023\024)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\017\235\036\030\017\017 )Tj 0.129 Tw 0 -1.218 TD (\035\024\f\022\031\021\026. \200)Tj /Span<>> BDC ( )Tj EMC (\007\026\035\034\027\036\005\001\036\n, \f)Tj /Span<>> BDC ( )Tj EMC (\006\036\035\034\033 \024\006\036\027\022\017 \022\030\024\r\024\f\027\026\ \002)Tj 0 Tw (-)Tj 0.119 Tw 0 -1.218 TD (\032\036\027\017\016 \r)Tj /Span<>> BDC ( )Tj EMC (\031\f\035\024\r\017\016\b \f\n\024\007\036\035\017\030\024\r\026\027\027\ \024\020\024 \002\024\022\024\r\024\020\024 \006\017\030)Tj 0 Tw (-)Tj -0.016 Tw 0 -1.218 TD (\022\031\035\016\021\024\030\027\024\020\024 \026\030\036\f\021\026, \023\ \026\006\017\036\027\021\t \030\026\007\036\035\036\027\t \027\026)Tj /Span<>> BDC ( )Tj EMC (2 \020\030\031\023\023\t )Tj 0 Tw 0 -1.218 TD (\r)Tj /Span<>> BDC ( )Tj EMC (\026\r\017\f\017\n\024\f\021\017 \024\021 \001\017\030\017\027\t \035\024\ \f\022\031\021\026.)Tj -0.004 Tc 0.196 Tw T* [(\221\035\036\007\031\033\013\017\n \220\021\026\023\024\n, \007\035\016 \ \022\026\004\036\f\021\r\036\027\027\024\005 \024\006\036\027\022\017, \027\ \026\n\017)-4( )]TJ 0.072 Tw T* (\023\030\024\r\036\007\036\027\024 \007\036\021\026\035\034\027\024\036 \ \017\031\004\036\027\017\036 \b\030\024\027\024\n\036\021\030\017\017 \022\ \030\024\r\024\f)Tj 0 Tc 0 Tw (-)Tj -0.004 Tc -0.056 Tw T* (\027\026\002\032\036\027\017\016 \023\024)Tj /Span<>> BDC ( )Tj EMC (\r\017\007\036\024\026\023\017\f\016\n, \f)Tj /Span<>> BDC ( )Tj EMC (\021\024\004\027\t\n \030\026\f\004\036\021\024\n \r\030\036\n\036)Tj 0 Tc 0 Tw (-)Tj -0.004 Tc 0.056 Tw T* (\027\017 \027\026\f\021\031\023\035\036\027\017\016 \r\f\036\b \235\026\ \022\026\022 \017\027\021\026\022\021\027\024\005 \023\030\016\n\024\005\ \022\017\001)Tj 0 Tc 0 Tw (-)Tj -0.004 Tc T* (\022\017, \021\026\022 \017)Tj /Span<>> BDC ( )Tj EMC (\023\024\035\027\024\f\035\024\005\027\024\020\024 \035\024\f\022\031\021\ \026 \030\026\035\017\004\027\024\005 \001\017\030\017\027\t.)Tj 0 Tc 0.058 Tw T* [(\217\036\031\035\034\021\026\021\t )0.6(\b\030\024\027\024\n\036\021\030\017\017 )0.5(\022\030\024\r\024\f\027\026\002\032\036\027\017\016 )0.6(\017\027\021\026\022\021\027\024\005 )]TJ 0.144 Tw T* [(\023\030\016\n\024\005 )0.5(\022\017\001\022\017 )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC 7.339 0 Td [(\023\024\035\027\024\f\035\024\005\027\t\b )0.5(\023\030\016\n\024\022\017\001\036\004\027\t\b )0.6(\035\024)]TJ 0 Tw (-)Tj 0.049 Tw -7.339 -1.218 Td (\f\022\031\021\024\r \030\026\035\017\004\027\024\005 \001\017\030\017\027\ \t \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\r\036\007\036\027\017\017 \002\024\022\024\r\024\020\024 )Tj -0.004 Tw T* (\006\017\030\022\031\035\016\021\024\030\027\024\020\024 \026\030\036\f\021\ \026, \026\030\036\020\017\f\021\030\017\030\024\r\026\027\027\t\036 \023\ \024\f\030\036\007)Tj 0 Tw (-)Tj T* (\f\021\r\024\n ICG-\026\027\020\017\024\020\030\026\235\017\017, \023\030\ \036\007\f\021\026\r\035\036\027\t \r)Tj /Span<>> BDC ( )Tj EMC (\021\026\002\035\017\006\036 1.)Tj 0.192 Tw T* (\207\035\026\020\024\007\026\030\016 \023\030\024\r\036\007\036\027\017\033\ \007\036\021\026\035\034\027\024\005 \b\030\024\027\024\n\036\021\030\017\ \017 \r\017)Tj 0 Tw (-)Tj 0.347 Tw T* (\007\036\024\026\023\017\f\036\005 \002\t\035\024 \031\f\021\026\027\024\ \r\035\036\027\024 \f\030\036\007\027\036\036 \r\030\036\n\016 \027\026)Tj 0 Tw (-)Tj 0.509 Tw T* (\004\026\035\026 \026\030\021\036\030\017\026\035\034\027\024\005 \235\026\ \t \017)Tj /Span<>> BDC ( )Tj EMC (\235\026\t \n\026\022\f\017\n\026\035\034\027\024\005 )Tj ET q 42.52 343.982 221.102 124.821 re W n q /GS0 gs 221.1023475 0 0 124.8351986 42.5196833 343.9672431 cm /Im0 Do Q Q BT 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0.038 Tw 9 0 0 9 42.5197 333.1815 Tm [(\022\t\217\210\b\002\220 )0.5(5.)]TJ 0 0 0 1 k /GS1 gs /T1_3 1 Tf [( \213\n\013\n\027\n\017 \203\025\032\013\205\023\002\024\n\032\021\020\017\ \026\032\031\t\024 )0.5(\033\032\025)]TJ /Span<>> BDC ( )Tj EMC 20.096 0 Td (\027\020\030\031\023\031\021\025\025 )Tj 0 Tw -20.096 -1.2 Td (\033\n\023\021\n\t\023\n\017\021\n\202\n \023\n\t\013\205\024\026)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0 -1.2 TD [(F)-16(igure 5.)]TJ 0 0 0 1 k /GS1 gs /T1_3 1 Tf [( Lateral circulator)-42.8(y ar)-16(rest at the adv)16.2(ancement \234ap)]TJ ET q 42.52 133.396 221.102 167.682 re W n q /GS0 gs 221.1023475 0 0 167.8073302 42.5196833 133.2702518 cm /Im1 Do Q Q BT 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0.14 Tw 9 0 0 9 42.5197 122.5959 Tm [(\022\t\217\210\b\002\220 )0.6(6.)]TJ 0 0 0 1 k /GS1 gs /T1_3 1 Tf [( )0.5(ICG-\026\021\202\025\n\202\032\026\f\025\002 )0.6(\033\n\023\021\n\t\023\n\017\021\n\202\n )0.6(\023\n\t\013\205\024\026 )0.6(\033\032\002)]TJ 0 Tw (-)Tj 0.002 Tw T* (\003\n\017 \013\025\001\013\025 \t)Tj /Span<>> BDC ( )Tj EMC (\203\031\021\024\032\026\023\022\021\020\003 \032\026\t\033\n\023\n\204\031\ \021\025\031\003 \t\n\t\205\030\026 \027)Tj /Span<>> BDC ( )Tj EMC (\205\t\023\n\027\025)Tj 0 Tw (-)Tj -0.036 Tw T* (\002\004 \005\n\013\n\027\n\202\n \203\025\032\013\205\023\002\024\n\032\ \021\n\202\n \026\032\031\t\024\026 \(\026\032\024\031\032\025\026\023\022\ \021\026\002 \f\026\016\026\).)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0.087 Tw T* [(F)-16(igure 6)16(.)]TJ 0 0 0 1 k /GS1 gs /T1_3 1 Tf [( ICG of the rectal adv)16(ancement \234ap with the central )]TJ 0 Tw T* [(v)13(essel at lateral circulator)-42.7(y ar)-16(rest \(ar)-39.9(ter)-37(ial phase\))]TJ ET q 274.961 346.199 221.102 122.892 re W n q /GS0 gs 223.1277869 0 0 123.5287108 273.9479391 346.199521 cm /Im2 Do Q Q BT 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf -0.001 Tw 9 0 0 9 274.9606 335.3995 Tm [(\022\t\217\210\b\002\220 )0.6(7.)]TJ 0 0 0 1 k /GS1 gs /T1_3 1 Tf [( )0.5(\225\026\016\026 )0.6(\003\026\013\t\025\003\026\023\022\021\n\017 )0.5(\f\023\007\n\032\031\t\203\031\021\203\025\025 )0.6(\033\n\023\021\n\t\023\n\017)]TJ 0 Tw (-)Tj T* (\021\n\202\n \023\n\t\013\205\024\026 \027)Tj /Span<>> BDC ( )Tj EMC (\205\t\023\n\027\025\002\004 \005\n\013\n\027\n\202\n \203\025\032\013\205\ \023\002\024\n\032\021\n\202\n \026\032\031\t\024\026)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0.016 Tw T* [(F)-16(igure )0.6(7)124(.)]TJ 0 0 0 1 k /GS1 gs /T1_3 1 Tf [( )0.5(Phase )0.5(of )0.5(maximal )0.5(\234uorescence )0.5(of )0.6(the )0.5(rectal )0.6(adv)16(ance)]TJ 0 Tw (-)Tj T* [(ment \234apat lateral circulator)-42.7(y ar)-16(rest)]TJ ET q 274.961 122.596 221.102 169.899 re W n q /GS0 gs 221.1023475 0 0 169.9679356 274.9606228 122.5276869 cm /Im3 Do Q Q BT 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0.14 Tw 9 0 0 9 274.9606 111.7959 Tm [(\022\t\217\210\b\002\220 )0.6(8.)]TJ 0 0 0 1 k /GS1 gs /T1_3 1 Tf [( )0.5(ICG-\026\021\202\025\n\202\032\026\f\025\002 )0.6(\033\n\023\021\n\t\023\n\017\021\n\202\n )0.6(\023\n\t\013\205\024\026 )0.7(\033\032\002)]TJ 0 Tw (-)Tj T* (\003\n\017 \013\025\001\013\025 \t)Tj /Span<>> BDC ( )Tj EMC (2-\003\002 \033\031\032\025\f\031\032\025\006\031\t\013\025\003\025 \t\n\ \t\205\030\026\003\025)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0.035 Tw T* [(F)-16(igure 8.)]TJ 0 0 0 1 k /GS1 gs /T1_3 1 Tf [( ICG of the rectal adv)16(ancement \234ap with 2 per)-37(ipheral )]TJ 0 Tw T* [(v)13(essels)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\033\030\031\030\213\b)-20.9(\035\231\213\233\t \021\032)50(\b)42(\032\231\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj /T1_5 1 Tf 25 0 0 25 512.7895 56.0378 Tm (95)Tj ET endstream endobj 1610 0 obj <>stream Adobed     '$''''$25552;;;;;;;;;;   ####''',,,   ####''',,,   ####''',,,""  !1A"Qa2q#Br3Rb $%&'()*456789:CDEFGHIJSTUVWXYZcdefghijstuvwxyz!1AQ"aq2BR#r$ %&'()*3456789:CDEFGHIJSTUVWXYZbcdefghijstuvwxyz?½t#ܐo&,<49aR# &Eij-8P@Qy76LγDz2ivӮrtjlsBޗU0QSuY,8U\2bSO@5 p'b% cvkQZ[WKl$2z4k# ]*qp1f=[:$SG"I}B̤A93R͸ ښNd6|bp=rJbA$j, *p c]Me!Is1 jam]D󱭲,6w|_ 8AW{*L9ɝ*,H 64q3g,D nJQyt06u"$Z|Hf9ܧfB/1ԗbN\H`{wyYW]]@5UnحЦ#|4mg#Mt]ww+YpH`*LH.Н*$a-c6ҵ4eɌ7Dvb&[5y||!\◂`w^id'#q n chbAS< m\V61%"/1yly11H!m!~5##=&Db 5gxaauC1$b\doG[f]lN|U3$F✖AvQa/F^֭73F`2XDoǢwHቡ2GE+&.w*W.]`b, ~㏃H#8/ t@])\bգ^ĠeAlA1^ 0³ă @',;$mK2Luc++*Q0&2M=SR\pwW0cɚRJA]͗ƒw}'PxŘtRWqlH,"$kS -gߴmk7.mDS:(%[*T%io~ʃI̐%(>OxCcGgj b[w& huۼ٪nj158;'Q!IJ|;l$~2r.tYf]`hE[W,3^]j*`sƄܺZp_ըF>Pat" a -LD$f׬jvys-X08sBg,eXnd}i8l1.#E3XuFU 4EtrbN6]7\j3q~t#Q1xyJ̎G^[1 t,K5<\H)Ŝ,j{mCmpVWXc8W&"p;rWEp5 MW@LI>ZA‰\kg(aJP˚XR#F*lr 䜷Ȍs!9dp˒IYci'"ny!pg9CȐ> ~CVyf0#È @,ܐ^ׯ\ݵm 9M>D1WWo ;)3"f,Vf$:A/),K(Dد4Ap3"Dx6IҲIE^8guT);Kūz)QYF5g=K6n*v$-vp-L؉DGGŻ1$C`zy*&%Lm /`M,bad:ʋ X@|* h;{ڪ\qDlsTi눒j܁$o7ldوSBc(@ EvƦ#Xr&B#Wh:!e"8_SV&0c 6dmu;cVVTScNNRizS):N,Z@ڥ3F>)!e LSY>XvJ ]FAm3w$ #MWdhqi\e}*\9)ľ#ؽEʹW chv^br#>Q͞SqOB:V$Ʀ1]~">W1^#u Ap6UaݯB5$[3vjeh`aAI{}WUU9$jTc}\<3ܻ(D̚zZ[gY rqЪ:SpNR1&\?q Ci$1"|^Rb]?%0X1mhyA>U͎VPc$2te.K26˭[5ovy$=w5#͟3AXny()1TU^<5]*ywkvԉՕb@h-^;l,UfJ8idw#<2lxÖ`YOKD "1=V=3Dm>vecD%s>&!00=J"E"*?24nQg8F,9G,OCd$ yg(8)`A!K)+gccOc)n2,dRjkq BgMEһl N;\3"]g$U /?\K4EY,ku ЋxŎenbnY8 (H/U.#.<-XYh[#3?n#E(*ڜ =M[4fuNԔ\rz kT$Y`7[XhݪlR}3MKȹg+FR ÑfxjGpaK XH#!m$6N{nM˚S*@H&RYeb8XNYHS˄3fmY:I!dr*{CQ>Jk|{bqFFFO}Eы% Fb`M$D!l5z ;>*["166n&1Eb1pWx+= s\e ,ZSOg`^6YK%ڐ< LB ;9$;VƆ. :.iz)r@4c}orkgH<52lt j! j\F׵iB[2 v\D3YEt^gJ3' ySA2:럎B"$HJSzi2DHH Ece%|Q(TGb*ˊu=Ћ`f [ζ``{B4qrkqTvώi7ELjy *Cg(uդqp5 >wXec7!c`LD\1fY٥of6,ଃIűSq$]8 q wa^wƻK1?JbqgL0;CG_(iohjIaAaG,"je#4 Y{|Gar,A b z ڄFwhHa0} wu H$AR#ȦÕe[zN-#'&QPiZX1b .FS }(4Z 2$E=ԁuؐ{h4%)ěrp_iuHO[WкHaM:ջ1Δy|q.[brHaR[%y% e(;QKŖM2v tgȂU%-O9a"D uH~& dn KMrl }O-΢geeQ ߶nǫN'B ,lNb4OLԞgC1c# ,Z볅yO&Ę ħ,M= 6:8< ]ĀuW&gVRⷙQ-> .ꉅ K.G#5Jٺ. :& C[#y^Sjw=Ƶ_ǃ-GVCNH$bq!F`8+20'  tOX{Ԝ DcO]NaUO/&̈́dDa($8,ukSbвg=x7o@YF>ZVr֚#⻬34yF,F24 AU3)3 b񔏄lYY rq"BTF{DϷA9Ewās@}' :ܯVգ>ECDrujzw!7#,8=F$3FvR @W{Meا"~!X<4$HْWP9.rA"D .%-%eCL+Ս.I.4d"E/DuĒyT]K-{E}p(}`FvU(B!el ALdV!hXܗF .v! ܃cINs&p# tb&Ez%y@r;i1ݪk?rXbi#P;F~>gR9J!QP{y޺tYNL(!VDpĐj$91G{ <E[?1<|Fe.MȌK  2R!5r^DpiM yњLkr, uaHUE''&;v4#{KfeX`%'L^k $P0}*o\#+mEʹV$ 9NB!Z16`>ey!0E"AH yaR$%> ƃ}]?Xo)DL@2(?Yķgrutj+= kf`ܭh7- m cpX֙}ş3x$tOoXꂖpEDjHU0FSS􉿔 +#ߤ9pÈ"888QK1%}o)('DKA{pj:=hT|bc)fa3pNj| <`g|.Z] Hpu˹(xF{ڔw * h}io%Zn"aTx'H ㊯yU;7ph#0*,545 w]F˓ÖFFrX>tr>.Vg"9+QV;Tj2q,L8W+_a&y}@9*PPr#A0fwޣ,kbaH I9,8>ڃEy% 6C@{Vp&"rNQ`t -Cpp&D9R{jF Hh"F'i۲]p0t8ja$vKjѾ5ULzB5Ga H1,,7"Dz\ R9|Jyׇe\#@d;}5y, ÑĜdTG<4g '|F2ؐ я1ɥ>O`&sL,C0 0otat!'Zmnڴ5Si>*}8n,vՓm谋'L|fi|i, >g3#R@@9TxL&.$\0 Sl\@+=EV^dF8Af'H,J3Sǔ,.R >݆* EIv;ţLA,=մ@2 TȺ@Uzc^W<ؒaq hzNsY.TmM ;*UȺIL'sARض[0 sNarg@u&5*%ł<R8P0dV>*;W@a~Dq䬻_[.-@uv;NvPJ`jOMRaOB0 e^K|R$'Ž|B \쫜_JlA ։t_ Py&:ɺ@9W@iDLD_³9|HGLPܓw48r^S/'<&v"S 7$VLI$jzܱtx[bH{`m%t=aS:x0$3'_z V伓 쀑BIJ'Ncp92d"O 6^0Óse-8Sܱao2[]@im\ıi,&lh5f3JZXl\r*MO^ա0e@JW $OLp:F%5a_DKlWZ1&$m@Qwc~DnB=627k;Su{oKNxg10R߻]P@&{U:9`wR]e^:12LYiR6Ģe:VBzT$dQ#սծpe289d-Ѷ I8JXa@ Y =uTPJSC @J(` b@W"D@nIܳq\Ju<MDtq303+OW%&G@>-Qbs.,=xJP^Sa=RbnRE#9J[E=\w@̘DwJ " 6帧66ɍX<q^|ҞYlQ{,8Uq190g -uvj(&,JA*!EDXظp %؟͡߃.P+ֈ%m麷.ZɶWX`;jxԡUuE& E^.qqg T7./ЌuST||b% uq# '.&ga $ a'E 6.\c ',dd 8LQ# D]]R-Q اΧ5ۍtui( 1"{f)ո8c%u$ U9#>/1}먮 l>w< FAD8$j#+,ltf!挰 F@H&.lj|7\ ,,bpQY`*กzN:LwTN*S ĉfh!\)FB':K.mRCrid7F hkȠ7ں51Iܝ,A "z,|!r"C,qzH+ˤZUGe, ˒cCc%WkS^߳'-eR" [A818AM@ht:9Y.%5 <ʟoPS~M  ,8ўNW3OaM%<^OBg6^GwVƆPp|1ǃ8˞(iG=5Xȓa^@ѿ]lrnB#J(NRvK*Zqk'ҫ!rՁoXF:۫ 0$`N4%k7Pنd@9>J7>!THi'$jLymQy9ǽk<` tT82[WA5 B1ZD 2G 2c\XĂH(J@ ZJ<I$R`@YZuR[QqV o (nf. M*uOl],zNo!ʙI3ȑ$+JЖ qbAj5q6" "o_9v&SxF=#c #[!ǎ7@|5dkjxe`->~iۿy0G~%I0^ZoFSqt$ת^rsStAw~N0n81QBX&1ȁ>v^aH|LR3"2Zaጐ2]qg,`HA [w'z,3 B6"#P5`=K $6!ت[N-iQӵWys8qJp"1Oarsj&&ܼg)bD#tS[I +q\Xse?r# HwD*il2G2q[ g1XL-Oj.q\.҅{3I$ $ rTSA7$`t=uFQ@G5#`\A܎\dq 2CdPl QDrjaëҷzú\=rNeOh&ntdPAOEEƫbME"O.6>[ÒK?y.VNQ90 4dLܴ:CDnrl\aH"3L#hƻ pkM.n p2 Ng@IovY,-5z-Ef"}8R$qʼn0)É=A# 5'hc ;9o+g,&S,8A#)uu40y{"#)'9#z= ].Q!嘃 %~jB2|Gŷ@E!`dj~ǎZ˪w%IO3|{,8,+v8۰:Ff$IU<#ˏgSr<ܢ14lYJB nr .N8b|BGܘe'05:E揚qtzRұ֙PTR Q'U>+[*SvcPy枖8g,H%H ȹs t^Jp(1qD)UE1v Ž 6yF'+"x >$'9lȰF'1DuTU>`vjջj/#|`Tm53ʔ:SiI$2ɷ 1Vx|W>JƔ'FY$Yڬem\! yeyWHpڬ\U瑨sqB?p˾5\x/A~]W$U@DžNwc^`rnnY$2dB% g˱GͮK$22lnâ,<iT dum'Ua~ڱ^H}p4TkCۚsۭOC4#d| ]5,$F|$ 3#R<_6r {Q E,o39d7%?<[z5xE-껳#O>aCiP"eiؠ I%do̼03rbl/ר(.p4 uA,QA h))D^@UYy}ajHy $"i]Nxa7qR5.+9$9LkL)㌍1QhJ^gp6蘢IU|>xu97!y6)9"Mԑ܏ejkge$H$ ͞YDMiC2SfG(9޸n6{j`cxJ˝;W8xjwqt`K8A4A\o6&$dQv$-gia`HEC]CN9) $Vkh[Hd1h K伒R9 ab&B q!p_g[:4$(s A%ˉjf]0[ԡ$i"7Vit#9b <%<9"IrkԘjS \]B=u1$e, 2r+H(=7:ԘS*af3IΑP!511*7;97,–( 8ާ~8Kb R̘&OlL'ީՏRݤIJ#[6kR_=>E& Tb2㎧Sl>QD"J܄[2h0 "-=Jypy.9Ő( $ `b\dzm~EeV"K7տ2m0CU`2M YA"N Tpdx' N/- HX|00NqK'(!Z@psaˑB0#YeÉH`Fqsf1!HMMi#,%&1/s:V皗b\To*ꁝ=|bJq5 hűָJ i_3ẋ! ԗ\3: 6}zGt.oO2@)q" ^ީ !oA*6 xxPČ%z8)[ X0x'LHqG(P%¶B\BP 7UWo^`&s:N߲ nxիPع&Tv1 a4ȸmCiEjό1,@Ey!6$b CVյ61ŌRQNRz=zK.yKG0/}wʐ:QFbDKḋUzNc l^f]6/2ۻpp&ݖi@g0FV:klfR 01& V`mD Pw̿6% G Of `N&\&6sW)Dm$@: 9#iKQ2ʷ4iȩȨ}*DڎDlT@Q2(m브[ڴ!,ks~j!bI`Ǥ jnUy>1<&O>pu3ƴm="p`-@"!ZF$Za+nj*g8FV$,;;Geh`sqG֏O)%D Q^8ø )Uiĭs R:K?lYZv86[D@(Ee WnhW_20/]dq,,' hÁYQIzWcd[bҹ3^s\$}@seĉe" 2Αz!;4Nd1T\gN$oCHm _3BWMJ*x@FF;)6ر@P0i} R”RI϶&: zTRVHA}d>BVmګPqi޸Z͗=Τ*;MA1yj i;XoޕmDƋD@d=A>cE"1<88X2]̴2'Re-#I4ԪE;@i.lݝX{s)-vUT9M|=04~U'r!26`ϔr^ȭcnĎ /9ۥOwuP3ۻSSĐ{`m,kpG I&!h6#\=Bgþf O2dg,hpypSrNo<|ad?xÆH(`@١6(`bF&!Guc-(O`]%[z bm^NҪ[@|/n!j.ZAX$IsZ]1'!c#8 $ҌLJ.Ը|rF8XXad4+[ DfD2AEJˡd&t8K7 拞 ŧU\8[I9؃3ACl|>1:AȊQ/0RJ')}z19&qaADXx& nZU9CB8c)`>U8Hh@X8͘Dcp@֎7#' d103'3Pu-g=h&EcR4aEIŪxOW*56 Cj4-'|W睫"#m^-F$3"HSbD أ$u:ר=r319Fa,1%C.V,)v"Qηک\#'Sn! +12[rw^n$Hb*V! ^Wmǧp۰=y.*u+7b;q[H@C:2?VJ8GX< Z@ m>*TEnZ|,H⩰ѽC ]lǟt,&KdzW^h=o+O$Ac: ƺ.Sp#cp۪V^㥭;$ڢM^ZqiC]N" $ҐPF(HvEu\ \'bȈd$B"17; a3&*%lm\,̧7xM%@=m2K! L 6qz"5FO^+1#EK#|`yFj9gЩ !Y{JGjfuP1+Uaf-b  p=.sVnjr?}Ŷ ˉ۶⸣rlڍ;r{쥱o:0.6QUtcyyG(@1;p$yjO208gh)$hi,^Z y Ԛ^e6-VP @*/lb[}'^}F qDN!gs\@sxID\cU&"SVw˔ͤ v8yy)>!D@hoLRwV3 m@_ն2}5e,%z/U:6ʲEeٰ8xb:&7)ca'+ 0^jcJYĕ$i4峙c1>,}jyBbG^\v8>B8\1Pݩ1=C8ed[ 9"+^ɴ"4 HջN`NdHQ@oO3x{TyLa9!֫ݶ%D>֐1vTR7,H2CDBHr[IBdAmD# J< dFtLSRÔyzZTR3`F2ݠ[l"`my0iZj$H8)թe"oJ*Tm{).[%Li\"<-4h^qQN9.8sDxEmY8tf-zZ[aȕUҺ]u_rxc,ИZ>0*V]X`0iw;Dl7PD&q 9le"Lrtb24Z|,8G,(H%.[&rFBbL\iEpBM( ۬W nG4҅,t,I>Y88Bv"1" '$:Y8x#瑘Ę$1a˲1Ld22!3v]\ RNb9Ҡ.*,(,@PL 'Tրb 90L]>JlI⅟ shJb."%nQ,p !T6ғfNkNmI@uGVw\3CQ& H17Q@ @14Ԙ \t;*ZQ`3+@69*ig*eaOQEl._a5e8svށ!d\+X*Gq%j`E]?&Ŏ# n"5O19D %,#}Ł'RJkGBF#,OH/5*LIN#j},qֺ2? m %ngK1ʳv<;-$r{)BN3.H TY)4nd e[D񠌎nV&X~*a\ ]n8b`\Y!Pasa`:pef[},C(@P#!u'IΑfj[VB:Z:TeV@  ka{6\ Xo>ңr8 ~6+C>Qf"3 %N>MGUA Rʆm7*nFq%,21&nJq# #4 N&tΊr9>Jv‹mtpsk -oFIkJ9:jAںL㣶 w:sjA[FGS (BRS%Z$GJO29yC0SDtcK@X> 2GJ[Z\|Lyr]9+[ZXسƜ#)HܛQU^GWeRJtwkC,ym5)86mJ 2 h9t"%jdH=\r9N7Y` $ytc?:s\䪸DarpY @JG܀Ž2mF@DZ,HNS$P% ܃{ S$df'DG6bGgUc7> .RmnR5k e * (0Տɥ)b Nā B%ZUhOF12pbÑZڣ]X^L'đ@eҫFXaA(Eȃ%D+)jRDŽzS3!Ue9JY@B(@wēޑ D_J1ay8;cvʬho):A>L HnWX^0P,\mrLvyhbn-z9XHb׸e8r4 m!}(#9(9o/+6v:eJLM7 ǜ/pXm*.IWe;NTyqx)nEV'ǘ@\=C.,g# 8 OJc @񢣍V+8l@"J1(16lBgs݃G<IloP(.وIy{kGU`Þ{u=KI! #qP1C6TEڠP\.%418}jLǰԐ*B6#~Tl- 3'h-XCH1F MU,\LوH;(o„q)d4| -߸ڤX IEDp"3;ֿ5oGUpkU+"a{JQ*B1 S1/:D%qlc(]Fʲ$=gSO]IG.;bX`ǧVx="1dsUT@3  x)Q+G&@F?%n Ϥ|Y 1f'Pc,5f3v`ۏhTe y2+p*«rNgr-mj2qU ֌qoNl_c51'7ѰeսX<%P R݋Yؓ ڴ!8̀pvh=ux~qʇxP1i4%DIm >g- ^* !;fnkG{\NF`9{v{vFS*t%UlS! 2A9$) #(qE&}CWv"Ɛ1&HI7ƄBƒ̢m ñ!C!Iyj;k?w@` HYL cT׺֎AǨ}j1"\IہתSC ,(,kf"W'w(%auery"F,r0|Y[6nF7[(ă0jK.piP@/WB Nms1l<pЁ2WLO&XؑK*V1 ?'y>$3&4:H_oNoXr,.C=GR|r|7#yȀIJŮWDF܀IŴ\EovPji+QarB0ṮA<,x=j~OɳHL h7&qĘ 7:v׬_%}<KU"ƫ=W/y%<1l6;UA}:>9iw6('Pˏ*<0'*>MȄL A%HF#r|s7i'UCo4Ā3k岱 /AQڰQh'Q$}mpKX,N#0EW͖mi $b{Fn b#1'Š"싁?.O—@dhNb>.z^gT ,A؀`JiEDS22*=="DSHeҕ*T#)s#Ҋ.ƽc%P7\.VDbww0^I =51cC\f%$ր> ,DX 4K#xJ|AQSqץ:Δ@K~0!XۇV`jpLxpr1/Etx:͛HA\+j aV m3 1ʔDj!ĩb"b^A(-c:udJ8p8|'IDU$y g 8'1 p5`\Fg oq8@b1jsg!e7 ᕔ@dƞXcN$4w1#`ڊq'$;t ֠<P;jXs"ev vU =-,QQ鎨4 or) zbs \Yr$J( 6\wD!D!`1  Jڊs'12 GBZf]KUQ5G[SI2;skTcp71;Hmwek:vE N!S@4`Nhf %7ZsṕI9%T $bBpLI1$8^㔱cr3 -4 6f/I70<0gӍ 22G&_}N7V ~r|TXxRƖX\u+KJ6HD<v71S/$(׽$$ĐOFڋyT"e99enN_Y-$f)1$K͆'b+qYwuTRi*'#ǵIn8{֯+Ջەe$ Uūw%]$=ULx65 8$`o;m@\J}J(BPG){Dvq9GFYA".M8(4rb:S ˊ(z0&!LɲԜvHb8O_vkb8{[Xkz -SZIBx.E{=3"BAQJBmZ|8`B32#^pKSŒzh,9D> T< c%pFQV.z99\eIN%1H 0hp68\f~<.ۺy4+:d=wښtkbn fNMTvfu0 wR%Ǽe"`&1yg?#R5$.,.M )NP XW)! 9r6ԓ~$9f S#driѰe K-dJ8K.LzE؝TT[nE .ٺ l=X FS)I&Avo s%@S J!ŐMXy@TД=q0 ա0"/("mA(o֋M4e8ˌqv"@2+}o(*c IP+ g|nT'0EOzzr^K LLH?rW^@pʎ bܚ3 ׿_%Mʢ  }z 9G~0WrS8N"(NizGWW`>|f&߾M8~SՋ~wRxJ01յ@sHS^*YIAS-BvT2*]tQF2mRrȫhQ3iuz~JC0DE_rf3sL{OS|?7UḄ\\!C$Rk9A-Mqr,-AT9)be} %#2P'26l8BDlǃ0&đŔWD'Q3̮Saʆ :+650# 9dI$I;~ul 19j SӞ~FRr.j`fd&6R"x$M uԾX egsK {;jŻ6iYg89^ZG٤ Cp+ >C988qyB= O's\;uXl|8@9(:7}/IpvK;@ jңsb͟ SMlu], #AmuCvPI_v/51f' JLڰq "}<)w#MT(B֥҂B@ bpqyjQe1A,p* 1<~[ .1 J,8 #N>J{b[u<'Net\0ZA*{ c~袦V۵*TT#Nqnېt=T6ӸuPFY;NWDJ*r(6Bζ:w)L$b=ڱ.m RXҥJNPkp 5-ˬ)FA*TRI$RڠF j}e^y0b?m9#M)RJC&8<(#JF=:@r&ڝ*2E2+-9؏“!N|ĊwV!@^a;Ԗ\/x TqOP6b (9ßG"#H$ Uqp'c TDHEZH2 rH r-ܛQUn BDOSaKB]OZ4F¬`fĜr^ltztYΐ6&s 8<()ύDp0K!0M26/&r)Ƽ4쩹' $q'yN@J9 M8y]**@+ QΕpR2(oVž4IzNbbB[Pc <1r۳ԼAJ:l7c$-s$F'VU8ry#ϸ @=OB zjtz#)1-81<*6W4<"}ꕴsܳX'"Af3` 짋W+``ӱ2bv<1Ñy.S*'6sNH ϾБMJ7V[#1}9N<Қ0NLb6`&DǝčvRJpK$%jx[q#H>SXc@B݇P*TR* m- PFǴMgٲxA'+5}tHvj"2%QJ*UŞ0tT,vdB I8U{$zzEnTRA*z0٤cohNMŠPy5`.&raGHKoUҥJWu*0tkRtE1*7 =3\pgH +o!~J*HRzhgЊ$`akJ6B*T̸rZ.nۗRquu˝-vŞrfJ*#(ۍ^9d/AAA/8d|I3a1u60ǔ%ek8&/9D$`Hr QZfm-0T9~u({wlD]b:[cN蹔R09MpwM ttLC1 DC:i!Ƨ#դ ae ¾{4$oC$$UϓF]9D[\i`!oRe'Y1)&B "/dI Mm)_c b+ѸWSz"6VW8TmHP<.But[buGe8 bשRPlO%cN%!(H(DJG(rr^Yz2*墚6%Pc!" FQ.uZpiX4HN='+T)U[u UKjꗺc0'm]G eۿbK*%n\9ÈDUn-ԼzEnA(̥X30Y?I"p”DOJ&GVY\FA[CPz5C=r-iqXA_Z SɁ#= (C 83s 0ck$-rJ!R"IhD, oT0Č3|e9B@ͮ$vp1"!bg!|<>y];;T｛X&`si * jK; R7eA9 Lٸo&q1M4 hؔ&N.r9D@ M*e9 ձh"I<̘LK,98MGDF2`eJQ&wR 4ώcOu E:`1)1D))fq2$GU9:})dE2:4FƦ`?,5Gt.Gyu(5#!bX)[ҥWNkjާT]"9KJY(ȋ KF1c{jDbKjUV`YbuнZ)HH l{C!Wp1y;B45c$ ,̌"@YF`2e>Tx{wwwkFDn("LI>W Hj.%tLd- qX=uӾ<Ǟ 0nq ".W`MTTHIyJ`jߙez[E-۽s"WNi”#Fk <&)0Rr| p#@[jX1cң$0"XĎ &G L)rraO31 e.)z74PJfK` DfČ ̏UZܗ`WTr.JL1ĉ63JI~?zȵ4F¥KbDj0d#51FVEHu!ME3K+C[yhO((ab0 1.rKbbJsJe)D1<@omjK6]dsV:DwSQb%-*TUwR"Ymm۰LHw[Cc okJb1!A&c*TviX`X(* zuY0 1 GOPiRJn:X {Z}£!X7pۚC-%5"P@iUFxTRU=!ym/Hl@-nfi3R[#9A"$ZpJ*wNB*7 OQԣ&%{ H x2LP$ R@ҩf,@jG]Lb|5}"V_<cN6siem,p3iFbNʠX'+v̾ןbA"n${.zWid# DrK@n*F2/mLe;<]5ˮU+jdt]&uYf`ij %K( qjTQo[-+3">sKv~KrXH&Vj+tkQmМ'+TAbGU@4 lt8`0WbO=yRdԩ"V&>$I&EWHI(Lf0ɐP3H'q yqqa7$ ^v=d( H:RSҨJ|;jD9x+\+0'KG0A1Rd#!"@{Tp#ɀP,c8ˏ8]8'~ ybz(IBD mDx-GZgb^$b^$$$%k6=!l_qqoh_PtAh3#Ԁ\$EusA~ΈȲg$ӁL@xvL Wk35N *y1C!U!)P: >Ԑ IRfDFbue{dyU#N}:aliKXc1H@IS82QMl,wt605ۀGzq0)Fn+Kh)f`0sLqLŔzGC,eZE@Piڧ G^wm\7UsvY*Ѧ-t:쉚./RYuA:n1F)-NQt$fM!zHJq$E0xԱe$-eR2 61գ<{v$ ,P\nvng@ F+39N?J=:& 4H̞F65t &6E U>l<舱GK*HL(EI=₾^!.SH$Y:?%Dn71x!Vc=A&SAb| O⭨* K $ Hm*A6զz=\{}3OޛETyNayMK9:Kt$AɱIEsk@Z#N)C#Sb(jMx6o3J@٫zMJ۸ ۺ bz۪JqΨ "8L  {cN8}\sH_JB&Q lˁyqbD% J3f+jX82>DS̰J!Ńj.M9HHN!LbJݛQ<OVI 2u[0:,dIngC X+ w:).Nr3Q$3mPntyBSaD,]kLȮ{.-$OCѨw#)(6%:$w\PdA,=r~]9/Q( EB\4)=lZX1IN O-Ֆɩ.Xjڳ9zu=b4ܬRqWobK0129#L[dbF1"gxE6|)Ɣ0̘`&Q` 0ET01(p,!29ٲ#,ȭX<̲d̩{e7ʧbQN9$4a1TC 8a {57+) ~0ςB-F) S#ХYz7 ,^SsH@4d!O HU5:X]"O &`6,v#&hfFEM5SaQ(#KŎ=7[M +ۀӦANi8XzawV Q##z^O I&pX622 G:3@)%mԼG"%Խڹ)02#cNo`O)5Zq{S*qAIE<iC>Sj)beXVe:T剉RDP1p1TL"P%Dz ;t]sHɓb,%6n5R +- 5JkK0gl@gl&ֻxTh">"5UaqlR' < QJfQ6|EkrE1dXAIB*?&ĉ9 Pbz@H)DX7Dp_K\?g/X=@ if8 Ijn#{עl:@'I"f3]fZ  K$ސ 3bg10% (Hm4\ÈSa8]l"Ը\ ͘fH!Y@˔@HDj:r0 #nYSU}5j".2EEU[N@m@b<ҫWKK^\ВE,IfK}|1!9dRDuzU|q9DHn \Q'&9LzPĕI^[٥&stYY=q !C(|t=ۄJN 郥h)&`)+-BUO O|u$dHbV.`Ovޫu$v l;R6@$47«JNH#'AƕmX3k15+[M 0'-.ðoW-X%Q렞 9Mc^TbbUMjǸσ:wO]kBtMtoZ6FY= >:6흣*H)LzTR,\%T*WpAP6csκ̀I<ފ 6RJ-W ɞz[fmr:OKRu 9H8ztRRiT2܃1K:;r%F"T$ޕ*T03RwM"ߐqm*ZL@>%L( TRES#82 61R[aJl)TFDJ*U\dLL rW¬Xw ג`LkVݴ:TE-)1ﮄҥJFn:(=d{Zurqd.t5Dn`a c*i-`UśpT(A. f_:TR6ZjSmq/fQwI [Io$4{y}A~=tC\K7n7v{G!ɺE;,L!NH [}V5A]339w6%Rm$PX$RGYwS4^}:3#fb2$Б8FgFf(yQHftѐ.9dg6[KZF:3_I#=R cK\U6IHu "A3]qX 80IѓM ZծRu3pV0n XS ׬u"*xB dmwd63ÜYA7s*(J`)xݫ xBKr22 2ΛGYL,$v0AS7T1TUx[m*y]Je.^.{Д$ￅ'O}X`actA 1LvZeNL5Vq#FH2E s0ԗgxS!bAI|'Ce(rĐ`H1  .Jp("YTF2$ \kzvR29&V}DF DRmIxmI1PSH=ht>td ME.P"08plX]!'x9^.1ԍ9SB!6EQ%ަL,#$J?lj덁 2'qP۷.B 7sTָ$B:o*A 芩e:~!@ (ΚPwyN&MlL YhKr|,~nXs!!Ⴜ)|*L!Hr1} x.,y L\q:bJ=h:lY$;@,ӏ|GƀKHFݴdݚT6y{)ѕ{&v,ϮgSbp1yb1ϪĞ#0Ǽ8+җt7XBzu='TVWQh2 ȇڃ$ HD[@j$嘄#zjlLYOZ "z lYIؚw Mˌ Cu5.`<<NݥTxcf9O.u?  4fcgU}STX Fob6%n)ɐʠj[!$*Ҥ\61{cD7-3R[%Y{ԒbSJFN*Trd`Wr"sQ%~DUIh-*5RJT,5N*@HFH mNF *D)RJ 1bTug!u8@ S3%1J*T`@ݰ]nbu@6#%"5cy4 =|)RJ j6>-JG\<[Tr^sȏoJXG#{J*q fR#ԪJ ~H&u2$)cue-T3pH>FKZSl{RJ=통%4yd]b-^NH3NW{tgO vMs1 FX'biD䲽M*TSntH}3JmkaXGpˈ-*a2AqOUQ<ڋ,*TSP4`0GL\i I؞`*NE+S'R@Ս.Z=K:@&0loRn妺A ; Y=^@]u%lZy.,-mLqH>g :$[WmۥO`n l)G^ګnªݸFAx˷Tc+ZX<-ҭ7-t?.u]@"Y3'݈E2LIއۻB=R!CFY$Qծ8`O0N!zhK5 O` X .5/pd4W/gCz(P@ 51D)'p RXFLz 6k:0lQm.`眑NEBGվ0Y=2c!d{i)!huP'Llan@}z("QN<z[hm}k@,0GOפbnj,LNq]eYC2-0-!I"`]kw8kֺK ¶JOi(d1գƆX$& b`$,z+2GEM4i N=,1<9F!O.,nQVj`1*BǙ3ҋ{2ڋm0BT2G(4[mmm]%/m2%=՛\albзC&Cw iǫB>K62DDgp- 1'Le1~ )ԃk I(F@0%apR T2#"q"" rttآ4*Yg["_ld` E#5zD. ;.k$O1$T:t8f Tƛ#c=@J=H1(-w#PD XNFXN2#7XAܳk^$d bL%,K@NںX F|(',\U{U&(g0 JBA< Yn&{Fyx#5. x`lF٤S0Hs(Ɓ|&2a3a_س'H,~Mc ^:xb-*,I0Y#C(wz9 BX.C.n uR,rH 2EpKJ%.C)$s{Ut1`U"6SJi^ByC0 ģM jUOQ1 #.fb]0NSp`@ࣗ&g 2(Q[V#5 <<7BReuCkrB ҽO>Y k A{\Atb*ZJxi4`Qb &Q"Le2 (ELX#8L{M8r{4qF,egT<Pe(SCzklxrpA0tZJNA"!Q].̅H*evbA\mkx`@)>N11#2[ʪ$sb! K*'fAV4>f.cg Ķ1'n5 izU2e1 ,9f ކ""ʢCSIOp#0"*Ə!Ï&¶.&>YLa#<++Q\tsΖ'5-d/p ϖ[JTq$(Sfgj2yJ$f f#mS0!o "7WR@R1H5Ψ c֦- ]G*tں5']ͤx ոz@L^؊1=dHV3or3XF(=TuԡGǶ~yTX]sb@^aS۳uۑH\+B륥bju(Sv < NR)ST;gcѫ(TF%,ARFU_4RHjo$`oQ [ T\ JLRJrLJB#;H%P)߼S gzz RJ4 )zNJа r!a:x3>җmHl)RJVi{'_P;H#P%ǧMI} oOo]*TS" &gRK+$rV1S$Y:go4RM"RI qJ-^Z>(& "*cX!uvTz!82HN4. BJ*Zœ\ɂsƝn7^޽j3 Lb0萈ﾣN\s'ԍ{.ȼC2cb@ij60|L #TZ}&ӭLL"*iUn qzCn4 qB#%D#0t=o6$ATAĐeDnԐ9gC6iE x/b`H>Zf2Dcd`_k >hNab\J@ŢHQ4tZ,GT|"KhKX ItLA5' 1 x9ȸpUkrݱu#Q NyT(2=(*G1&@Gy(գ 332(d!6-1!hx qaw"2*!Efhl%i[@+q+or֟=pAcNs FݛM1զ56#"XfqOqh+.l(=ciUT R:~TZӍ{ucrC,Opc(2BjqRNxr  H_FF0 TpɃ.hHx F5$H #m)R3ph KL mɫV`iQkl5 1Ԇ'LRe0ҽRPHhA r|Ql5J^M.֔9W&1cĉ͛ĉe1~SUƌ1Axda(<[*Ǖ1b1b @%q Ӭk.3@65!sRi$i%NqƱ,h fjSb:ˣF՜~]Q9`DBqr1Ŏ"e8S7Ca#V8BY$R eX[3x'I3YnMн*7C Ni FKA;&睆ky#p؆34qb0Ќ NXQfqtb] V氰c2abh 0yd.H}(j|<3p.I`XiJ%L0rmm-+۲g ēJr?U7e9&Ǯ 0rE=nj!/qlO֧F,a@XȓedKISGŌH$lj;ݶh: Ff2˷iT6N c=bO bI猣iMJ//fQJ C Ѝw75?)JdtHE:9,a[S4Ɯډ:9nYq m@8-+ zK;^aXslB0|PnLnM<aiG8S\no*qMj (2::5a(Hz.G0PnKօrAz2E*q2sP5[,SiUVrYG8w=&Y_] -޾4RJm9%T=[6[RN2tL ߋm+f&{1M5HJ$z4ܦ,z*TTd^hq+uW\-!VVHcȦ7T00P㘦@[F$Ip}.`$UN>ZTRKIb;ePwV,>ALk)N䒣3Lu"qI;=TRmmCL p6mRuA0 x^;+>AsNe$9)b7}12r}jnIΞ:v>JMD-PA H﩮Xe+hv>>륯LU?]>4"1Q)@c CQ {SJHbyHW~woi]ɽӗ߈[_Ptm.H7 D4CuR">bq{EI}^xen1oWCB= i"[u umyxH7L)qNy!+JJZ8EWK/ >9gA`=HԸ~2d l(S ^*261嫼WI}*ob/Pj(bs3 HZ Vs0+zT>[T)jBꩰp% N$MŁ*(%)@r܀aF~)Zc[S 1oH2uF1S\2ǒ{?,ICRc3! 'TԌ)B ARFDžEh>Ce=ZczQ۝j[kAΩ:p@* _ O'u2B{6^LK6,V~SUg8("$NR dVޭcG$OQsꊯjn妶d}z|h 4Y @5QU7k{i#b|8I͈Nd$xox{3Ƈs &X(Hnx^'.#W Uq&6dԢ )nJm!0DE/}}*}s_HR(>WUʌ!#Q%K489L%Nl=(Z0_*3)}¯pg'qS6n **S-2Y jQPfJh$>:7e~L7$!؁\bdDAD&zqCⓈD$% U_0UXbG]u%Y.B3S^kɅhc>֟kK?])k~?HPGFo!>698 HbrBT#H܀/ZqeWCz\%ѨXAnS:yN1;ʓϏo?D5ӤPȗt=sT<^sODd% bAZz*I}NYb}pǿ$}jx~P`F&g9cj|yps #H}ZNRIs)cF!.zCѧvʢ 9} &GR۰n}*<+!VWSPjX꺨وbd1$X=Vǔ Ï?O#OݞIū^{kzI]AZpN7Uzzum< ?\8* ΂D:q[o. 8'Lo b<+~6E֦JYq 3ˊkÅyd <:|/)EG ȃJ =uME%=QZ@0HbnR緦7JCJ*Nl4w*+[Io4 J*r811y)cn/-9W1ƕ*T奷Ub3p=Qgߊ[>B<34yG L*TT)ČMD9wlP/J*Tz5K['Ҧt43])iiF#(;TR[<,Ni- $)jGJ*U !UPdK.]$8R0f|: i6P0\NROhUNAt)U|T:f)RJ endstream endobj 1611 0 obj <>stream Adobed     '$''''$25552;;;;;;;;;;   ####''',,,   ####''',,,   ####''',,,^""  !1AaQ"q2 #$%&'()*3456789:BCDEFGHIJRSTUVWXYZbcdefghijrstuvwxyzZ+!1AQa"q2BR #$%&'()*3456789:CDEFGHIJSTUVWXYZbcdefghijrstuvwxyz?˱KGA.PDN;L9[/*V Hom qLSf’vz.]7d853*[q'Զ &I驵0JH]=xۄMm䆷7:#D)m;ILUI&J+A6J0r!]9̹;ݜR'+V.0-W2F \kİɬ<^70(bE,RIEFF#jieoF۠Ѵ)&h R7l06SSn FiӚqi Z_Z)vL5@бM%(BTqFG1uB;2CHڜ48 p%0*$[UR_xW6&@R@"f=(z}Zp&ij$tLȀ;P @[-wZ'O*T !H^Q3ʙe5 ;(^hySz pኻvN qW0nÜO]Qui{umb@)VlڳE]vMe*WĔ/boY yەYUQriPFRrR'GV~XIļ*RAj*KmR*EUOVH6zM).M1zľt^.YutCb5PVqx9N/⨴S,Z4/]fV 3]Sɵ]OSq}Op|{*ЪSQC.Pqxczq]N [j39g5{QN Y*;Ĉm;Ji4 qi55S'RW ER\wnW=\V*ʪII*$M8Bݛ2R XE*[8]B _bv`UDUe'KMƠ'5+NԷ*xSY\5QUU'e'EwO1[\p k% MkAXxPejĒ;޽ʡ3Υ,V A ]T\ /ܩU6`EKLR+M.u5NPDѦYn"BNA;&M*S*!bKʯ,M21VG!𺔷jh> n }9Z/$I޶$-ĮJ^丐/6ja&ӷ*AueN&hYa LrUR8`%2*VnSu0 jКIMM;#OKMХՠQƺ ۈ 8Afk*VTZYu;~>dVqPJH\^!V xvU@OZCVNQƵG=WSnEHd<^vxWjӥW]1!K9:-U' ny5ဳSX}Cfm`Jo^1V-#B)K)]4U:I3(s&<=UwRzZm4 iv-J)PUĴ htˎUe\.]ҴZTvmR7.Q[Jp' *kYgqU]hpɪF]Ks,Қ`c\cVj8ˮ LڶUOk-oȹ4tTrudU؅ֽ-81&؅ Tۑ ˠ|K !<njgMR'T$%]thudW. }4Z}4xKMQePڙyX*RZdlTe`Q5Ш(ME$n5[PMY2>u)iEʈdG-n7\HP1ΕUW+S(Ue5JSn+,ƗBn#sʥ1K"@U_s]ܩ Y õR :żZ(ꊿmdž&p ɉ=i 5unjTk\-qt5AڭNr#^(vo do]SHnu·MUvzZoaU\E=fN]]{.o*[#.ێ"7Nu'Ri,t\Hu [ l( 9k(W$f&DĿ:h)sIZ'T&HTڅ\xR]s* Rvjq lKꁪ¹O͂s>qxzad4E恬Sp&$N1%ܐEb@.2"(Uf땣VjwۨOT]h,Y$]t12[].\M ĿEt8]5It]. .ܠkO@D{5϶5u$r *U M!㐀0U:fr(5iXGdOp7Ck0M4zy'9HxY Jm/:!$CC6hä4 (֛H5a zE4JZR AiMwВ9UPYMqta נ_NEh$\nHG[|h vБ u;U6Yx82YtuUכFq"ۀGRq8cYH\VxU[rw;!A7'TM ndU۵M%N2t^AT-yC:tMaeN!˽QiZd\K5_H8Z ᛮ*ZuRSWE:Ugbt)_*a]/S;d5ڭ\+:ðX"[2KOd*b^j& kNQ ڀT@6$am\=0yVjK&3U$iFېU+CKs*JLZ ʥ?Ukڮjm*Q;%h +1iq*I[5BMiuP]yi5'e/" ӭ͞ALEq݆؟MJ{UdU:) tAd5B&O:A(zZHQy֛ir)L NR3R*mJ\onզ'$کgXUȝ:lMh,"Z"v}EY]iɸRM{.aF5N W`VOS31G~d;n\OOUiP@!UpT'qBVpqnYv螮p׌d֤A}57^5ۢ+ 9*o<.!KqkT sydo,њ5sT5 i$@* x`G2OSfh ruťZrwuU$i#T|$%ՆQ֥Yuۨ0@dqPxǟSjlj~7PԵ.@녜bkf cj[LlܲUZAHQԖj(M jp^ǝAq F>g]kXUx:X9#ۡdy(%R,m.jt)Q&MM(yѭ[d@֓y #D ӝx&;+7r/,Ѫ9/*ZY{~Jah@n!\.txҭfFR[TN!!+'"YŸdKՏ&m`(M Hh`\T_ny!C֏T-u&PIdr4$^h [T JN|jQ2DX/PUZOy sի vh{wVۘےE`-;-hf9x\-NXZN#;EPU*A5'kvId˜9P[R"%ucFJy8جKE%{43Yn.l4.W5S Tzx=q#T˲7; aqR%K%:`:.q8b\kp T8T pQŠPu9 plG|P5kžܚ"j‹ʹk7_{{RhB/S+@ifp&zVE^-JPҹm":L ITf@T#wuθMj2P,jN,&BUY0*e-0SPoPf+gl"ֱzLRŎ'SsԃPlNj]1~ Eo0C` Wdj:tj gp+g890Ywݕ֏mj7bEJ͆d U\B$ #nqR>۠AIuc[o{AG-Ovn MҴԢ=3SSUq-6Y޻m\]iQ/uIƾu~M:L-Lt45YRk \sZhT\'(-$Gek +&CTRIEZSC" ˼du 43p6 a ]]oZ@-Jx = `FM.,PI$%`R I&^ :Y,{4b* .P6>bs&n\;8CU]"W:@M57F<)MNH!HPqY`-lA&c,}WĎiހZxwc2նw @Wxۍm1@H]mY銸 4rF5V.0yM;RD)MՄ$IGun[,v鉷٬|/ 41Vm75e.5$id1^*5}\I'z&n \`zk5`쵋*A$PW^@̄å6 * <8G^ oQ$UŶ 8wCT ;ʶ%g5)Ⱥו8HkjgDaS' 8å8 ңi7rFIm ܼ'I7pzշD/UJІ<15+urTn[v mik)`yԒ-K [b;h5rYKiMJM*i-2Qk %PRiСRJF4bPn Cz#)WM`$z?G7NxDWt5J*څKJ+y;Պ>fjphMh\N]0nV'UtIZSQx[Rr8"vuz" w=Ug ^QUJ]u{BH dܭBEk'2n26 U[h(K֘e P'$⸠܃ژ &9[!FZC c!ZIx zЉ҈ U&MUzH}p-+s\>^j te(aEU)[ue,ԩRkzT&ʥ0i a٬2 TRJMXd!TLz&+TQ擸Q}ZGpmʵu[h fXTg2{l}@Vhցq@P#Uɶgja%a)L9ިI EhYx\IY@vrqMuڈ(~SR=![Y-U#a6.GTd$oU^@ăVh$ݧ&H)`)L컇ihbz"c\y־ K%H4i6F*FIM tWo x(,j1a&@5}kڨ;9fn6 rKi$nȩp"L* ¼i_*+QJ R/!jd$.tyen}6uIi6M zEeySK:`kh1r`7\.0ցDI\BPkou2Hm 'VǨ9M#kCM2(u& KKv(5cEJ$t.6bF*gI`,y2IpLƼ [o[Jǵ DI8(~!&2Ψ突v"|` 25n,I&)] B].^i+%ihVKҔh%ĥZ Jkm7*Zk/KΝBJ4uTsD*Eu@m4s^Ԝ.ؘ/di# 7 -TYQVYXL˵tQi=\WwzqsJ9ZTאDxoE\RB[pJyQY8d:aGeu}T^\" !ԬF' Lǐ֢Vixd\1"C@кn{rNl69! ź:K:^p g %!k:miI{ƭMĝꚚ%aWM_ e@-J*WXbSt-%TI^Y "٠*RmDVQe +Fx jQPU}Z-I@c``V ǝ *Zt6Tݍ/•V:!T-B+5p7\P\f`+?ӦneDž5Jm(ѵKS]$7ҽoRjU$UnY٪v˷4 ('=h*Uw3o u. 5qiV&] ԦtjҎylj8bEWYV@!M7jFv<.,MS߬B&WuMJm{.Tp_!BDεxV[Mt[RT4c =j0_Z>t*jTmMJOqHڬ΀d"=}f}tTx$U7{VJ'<9m\CH[ kȳ7I;9U@8hW[nKNUj%eH5)R#: Aj$T2]"h3J1"7&YdAIY ]}m;y$DiW ~jqթoֽOL3 W^WGثUi©`:J˻HIPU6xWmwdMveWqd$]wB;fz["o3ԎWҬ=5ITQW*4]^Z<⛔nN VPp y0n*pljۃ1Րu%U[[9<Mэ&x**]Z͔M6dRSn}!:;x!5;!7=i3Bxg^mB))Uv!*87ڐ\*MZ.#ºuI!-4 snD*aHK*%aѨ-'K-k !xVjY}7;VI&ۖDV\BFiY ; ֫nZ`Y%zЕ[3ҧ d LBZ?&)-@ҤCL Jl,]u.JǦʤ'bB xTp~[ձ()2E`N2TYgRp֘WHMZ-*ö9U D*W>61Y\ wnX&]DPAQBxдGBC3O?ROz?RZ  'ŒRHUMH{<Fp4v<`9]ZҗhW-zZTR+ijn ҚgUZoe֣on>\5n5Cv07UNMh9/\v[Tq 3vqnBM)*VG8@^`_hz0i=mȑQ8OSW뉓nm֩?zkxǫ|!6p=^+B/R]Y)~/,~ aԶ Qi%1Yp J.u~W{/=^(vwsBU:zZjgdH]>H]Jw bmn[.{ݪYiiIDPx\۾Aq6mp+8hq{2A# R ,-P(VK8Fg N֮Y>^8lI Q'M7Rf>Ua--mZ8AEyնX~5e*KKxBE(0q/ cO#VhimOƴEU7ĄUU+mH3RmUVwJɀcZ]94BTSu oD[a$m+YԻ jSZxd9WjvYŖuk1Wpɽl>Y!1RҘȊn\$ډƢib\}jPtOi 1TlrJp XȱJm"K])֫F Hȣ"!m9 J+jy!7i T2\, 4\;N@$ۚOJ/m֬k(PE( Ԫ-&K UUuEE:Nt6uWDhiZLX5 kpIRȹ<0CN}o]i:\ P$J{5.T+'9W՞wIv}Y~nX^Gռ^ARE(,A/ k$zŽد4⒧0RѮf}qWEa b-vT4M<8U琫o]s.aWFYK0%SxM- *UԵ^@k&")RJţIfy և E' eϔ)]uD|jl4֋&1RsdzjE*Q5;2d6WugTkHQO?;) ^:YLMiҷq~d@u(9{_v¤4Z U湼@v/Z rxǼ@5ԕ a'E&R$]D"rPTRxkLeS`bU2W$caV2Nh!EHʬLKH Wّh;P44Z-zU'w )A$(D Svp7-PF䀊UY!֒<Ҡ@w  O+h ftTgbt}Ks aRkô+b3 $w384¶X{uگ O&Κo!,I7IMÔѦVZMV ʜ\mr.!jo^JۢU*L/9Әw$L[(p<4fIt:'cZpM4$P6\jz;Nql>`hl\IGQpLU U jے`HV3prU[ à@pJ-? A(7\GG<__wu=R0L#rHjNԜ4N )**U5)  *T\{*)v졭%,fCœQVXQb5m,CeQ UwNK@jFօ]Wah& Ipd2(GkA1L@&g, ;")KaQ5( !sJT`qԽ\:A|B(TDDHqbKaaM.hG֥7CdeDRLj]h)dTY$6K5Q>VX8 wV B*#DPY&AjA< T@ڕGA9g[%W^m$MbC/+W< >nY5*Li ET86YuI6ڰz4jTۭEk?e9՜\|p 4T@K|n 6r\aV%-FVN]s':RKp)**W^RtӤ+4LɩRJzp%T77.!DT UVZbb^i= Z,,U6n+_7@$ѭ:e/ йW%vkLfuC$@bRL\>1ғmָr) jVN-Em[2J]i(TE鴥z06SA%SD@[5*̭p=XH! 1Xxd* YLFR*RcՖ=V.KXQmNr#J-+e<╬{ĀyUZtu&x JĚpSĸDUwҕ-3WZc t,J%q22kxeFMvjm)TP& LZl h{DUV3eUbp @Mf^NXV]cXP=nt[svho@ʪΠZJ*uMAɠEJyȴD[\Y¬- \- =ߢ& oV2W; `)+X1=;8rw6]4 CW0JF\E Y9ҌG jP7i>xJ$ 5;¹]:&~% Z< LDrw:ӉM\/SjovU.&\d3Qb*g%ǽַq +տ: r ؊G 9x{9[Sl3v Ph!W v#٦<2yڥOL*1 (n;-kCZHiW84*Uw ;6i(R~jP U Czn Z=M0:55.dgUpOpn<_fTĝ(Te4IGE%Q}1Ҵ/'8V8`4)QtƩ'7#EPH< ҜpН( A$1-  ;A ¢ Ҋh+jT(N R #N4.eѥۦثDmV@Tk5yi4``-Aqʅ+ @*UmEUv]$MAuM KnLUJq yڟxp3YA[]Ֆ*qHjQn& (EPH5llAbhjX"Π`) t7Zdf̰a:BP<;z ޠ+!6V]yo0}ӎÊQh NKBwO* 5Ti<ԫE|*nU7w@yo\y*b즦M2'O7Dֲ{vKsŸ4ے$ M2T)+\W`XB@1*MEtʜהh(ްxꡦް SN H7"T(:}[78SShiÂ}i+ӉYA; a%wV Me|)l [U@*TT,M80x eӦ^ۅi4MN#JISFp] 릚@l$U*YLUf];iR+y5RYa"UeV 7ڀ@{ 5+p8Qҹ`9,j4q=Wv)RE Á@7zuPuq9d=3SIPǂ׈TN(H\ BIdQƢ*k;ƹ<38s]P dCbP$SF'jpo-:%V!r!xKBixT鴓oDgPT D,Zm M(edF@2Lb`m,1 8 T<Czt ¡@T- T&HBԵm4 zRԄ7[p2$fW*4t8J\CE\~ (S@5}`Uv8U"^= KjQKM CbRq.&ʞ#^K@54TaS7.4 ) ZUuj\]TN9i%AKC2= m Èm,HEڅPń,j{TTIXU:ڥ[PW:[H tnmd)STdl%Z,DĶ]Um($Ȍ&+5xnCHJ=@l5u[éb*Sͮۈ1oSΔq2M\]v{U;5%rIjgf=)JύELEJ` FAɬWp` yݛU -!$o;c| * hMoLQUARH"Jp8 s\n&f+{֐i$EEݍRUJ6o/b{"ݸ8yR|ͥIbRxw:z(bL1&.6ۆ@R*BXHCwXB $[iBڈ,#Jp|iU"C*X#*jHI)w]M_xA-x[\[Q&POۧ*g )Ģ,+bJ.T8tŤk/ H.TkLb]7EtWg\ 9 BO]oEjmfW2T R(̼TictS9&M^9Sݴ܉ފt4MQ$=-8J[YοYEU,!V[Vp:a*>stream Adobed     '$''''$25552;;;;;;;;;;   ####''',,,   ####''',,,   ####''',,,""  !1AQaq"2 #$%&'()*3456789:BCDEFGHIJRSTUVWXYZbcdefghijrstuvwxyz])!1AQ"aq2BR #$%&'()*3456789:CDEFGHIJSTUVWXYZbcdefghijrstuvwxyz񶷸?Š/^J/Nn&qkk4CRmnC$J&۞ķfZcH/,DO48N68 9\_w[aκ{,v/]t_ 4_E 2)IeG$Y'W(킼U='{LC?Msxw48^أ+8̭γ؃^ݥ JA}R4ȞZ=h;bد*="]}qS.jGLt眇"S*{R÷YeҮAyȳNdG^jQڕk38Ʈ^CN-adx2Q5vy7ivΕr Ȩ\J֓C( Msjhkw=j[Nb53Zk9{:EO4bÎCPO#yݡQ5w5CMfyQk$*+|Vw8v9y!nމ);r.qK5d31*bkvNXZ&9oD8Ѣ߈։*j1S<| X}[wf]]z/FXX֌yJ L]r3Ć+7 ibjG5|HL7߉. ϲҾ+|JqgωN0K}=kV4jWCPnDE')wp(毖-.鬑Wv|u"X\^'[fC%7VU\\^k0Ji^!uypô\e]Sچ߉N?+$xV{$8{暵9$x7^vO(։x3ƛ:Q%6-O5|y ޜ$ύ|ur_CLUm:ig>7k ܋kʮ-[ƹ-YG|^O)ŬE'ZDKM>[tqO5XyUۛλWL8(yPڶr.I4Mt~[֛Ƕ&Bnm_S*C¹Va6Ŕj;0]kjMvV#8VkMh(qJ\q8ZJT1'S޶O [8K T:d]X[;ttǏ3E!R-S(aO"X(9Rkf=h對V]8zLeᘟ'ϼJs,i*IJm/5!TKs7ۜF^Iy9,zTp.LB )7/$Oz$k8.O3q1}8x|]ޓITmXxm9(ys\ziہ+uOgXpiCr)Xz]99=Ý{ SHq eO=mL2]:MOhK?Tڶ>IZEo9lNm\{^j$<8O1].uMl"eu2cM+5gM^stzV4H G:Q&:5y5_GJ{ χrd7c\V t}u<1drס]G srSM$]n9w5azq}XQ,'4کLpfs\UV!C"~WqvPם^[3s qȰ7y76ή =BqW\ދtF6eX \{e4Tp)Qq' Kmi P$H]kq-M_u62|;PE&rK. lԏ5|GyYu('.vf$/!`XNl2Q?ȷQUtv-mQk2>'npd+ך7n1.kE qd%$J0$[$ujx}Yĵ>L :+M7An@PkZ8W)$֭7cq0aRڽ"ic@^?.c$y½!B`5NjXkERSZeHRC" 8[gm*8WI,S>ý,yjO->la̞ Y՛m7KmK|bZC60sd&Ge{iet+1|+xN&:V8MͲE;+=IW%)ĺnnwV%]}>:-*МW2P&̓KSUbc\\Z- s]FR(6f]e2XK\0Q1TxvqO=^Y -'Ekͥi\Z>2}}Ss5 *O4$FTuChr4Y ySHg o%D1XQu;́ˮqLfO?ݣ͜4ԩ1g#r`KhT-bnNl=UYYoۭlOLGVG =yIwi29&%DEXCf5wb-*.:KO4޻RΡ=sb۝3j(rE*i\a<ޚAW)$zfKwgir'IHzDCog҅Iwėqm<.0׵qrtv|֙xW"B) gRgEmW37> NS[袊% k 18굵NUnYUKT#9uzvti^'2gX<))@"{`:-bgM),6#BلIkyGI>C_inL3Vh.\[ϋ+7%K+s< b-sw|:S1s8>n)\)'8sUi+68 -]v"ytAw)yMpDg]γSŜ&%#Ģ#1-)WågNm|&QI Üw5ukY)ҁ8PuϢggӇ>'WȮxP&wQ5^4W缯>4ycbi5HmmbTEzt8ؑ{KTowd)bG?6+7mIj9LoPX"lڐ<)`=&#i mb$ty;h`^oim^Uf3]E$4[SrDu˸D[稚_m+ȶfH_Ȑ]`|j ncjNG!sU~-=D\|9k3kO wMzwgckm0Y@qġ%6ȈKrPk=0Eeh!jrJiΘ, nM)'PX1['qTzMxN%\n49UX_TMyu2)Gފ\&lKdH#9W6'8U~#,>=kaw#)Ė,CIöIk8N {mӕg ՗y/5֮ 5ϟHWӮH!J7੪ 5u!oMpD;NIHMQI2'l-:i[ꬼn?%5)iUj1[!k֢kԻ-,EVnt:zqt7ۭMj"& Gpx-k;1ys-UkѬW c۝YyƜ/Ek-6vW[xiԯ-c?*GvI- rTXMedq:e*s5#^Ww+<;6&GO0֒]ncbyw 827CN uӡbTkH›K&nĬkb]=T]u=bՖ<) 4'wHu}wMwzoR]ˈf18Қr,h[]xGB [..?Ei]bHsש/7N;:]5ě!T}6AitLUg 瑼mojy?'zaf\g*V-`2ťohn&E`Vsg6۶R*Ů:NY Nrڗ@ QV5n2z!- tT}4J@(N=`zW}}4] LF''\s,843NS`ME%}'>oG ى#Ut([fzS/[=st4!j>bY3i5ehK=CM5eje*P; 6C9Vqs`}SӦu*j-֢TeTD'I驭^Q-M<Վ_xg9Ah厩$dR)򋑂xG4CMk N%'lCX(]t\',&RXg>P(}F5mz=Dy/f[po)-m3f]Yת־pwЦktsRIK*UϷ.}tUp $xJ63->S]~Wک7,J%987<|Ɖ}S[x1+^VbJ-wcjxRZZ6*8mp|vhZ},V_(㥮!#.o㤸aqY8[4n`l-E'u6%yj-Ʈ~I.×(hɷ^WĺҗƂ#*:@ 5T:U^%lTu0L8I k^U5ˮVt֎Z&&"CZlW|\ W>c8C/˞ mzq5@!1XZ-w5yP{KF0*hw|j8w_3jɈz*d:"&?gRK%c3LqaYfu@Z yf11;ޜt6Amd1P0]dfu 3SJ 1ttg5Kt1viR]mekoh2D:T@LQRrk˛.%f*:yT]7[e>3(IEMg/JT캹:EIt7RcOuR4{u6}[v0Qy6MuޒCtژ"bfLHm=!5R:F4ip\"#|tPdZ81O50$(/KAw U)}Xе]ڂ?Ҡ .L=5UZ1zT_U*n&]z!k)Xyl>򫽈ϞsEkqT|)8={kTY*A[]Wf,kmަ=u:>:Kk[<^])CvFKiv)W dF5Oا4YB4X_{ ]ut|u|VRO- ،FcMcjH)k8g3)$ f(Zr$ z.xii:k hJ,s }IOÿn^xU8vFK֦&\oz<p+YtcW1]& M:[mTǯ4Yv}c\QzcCEOTq u3MxTkk& )l t&u^Dg .)QY]TTQE^42LCi PtQEQU"kWQAh=ӍBIC6Kk&Quᰕ]HR`u9)[ LW|CL8Ls﫝>0EBp/c:i @SWlNi]Hw,rgznęuEZYvs=5e&='z]\m@4_Kvp{D{}hQMdƞnJb+ jk@T&b4Vك8zy`8wٚ@DQZ9Քң4IvI;H!(L\ Qe͢ym ]Mcyĺ6s:R%ذ3cXBDV[X%czPEMWŒK# agfZx~4+=ɶ# }  )BE=m=cO{Tݮ$g9ժKiu0NK.ҿԣ|S5Az/6a]Z$"*kWhQ*;kz_Ҡ5Pζ{^}-τJZ \]20mO4\ L`uhx B[&',EvtZx&9j׊@ᏇlPBgA+)cTrAyFkCqo;eMMRk]s5׵7TT^i5b [,s[<:TݍILH窮GB%̳zoH`J3gtH<ލuMĹ^efWHnL) `hVKg*jOӌ㩡\;b4s)pooy@ * ֳܲr7yWq0D N$\a3.w·!4V է/? FƏ*o R*5_]M#|Qº}1/\{ UQ;KnIsï݄?f}cJ@6!(W? W]s*mc_]Cb:|1JA!&,QS22g>z@0֙c.7hF|͊*IzQ7\f6U\I"]y7[DFwCmә:uZ9J[NXIuNmHՎ42 .r'W7b Ϧ&wq=i8DŽ=LL+m|sf(J*.\Tq[tڶ)<,3Tq,L&~P1Ec%r=k8[bG\ưa^1}Ef_ˏbB﷫Typ|%lݗM]:2ii |S7s`ǦcUp`c9fLD=(tfWP1k_0EѿýO]0jJ^ڏDހCySUZrj,{wն%8*<"f'@LBU5:xm9w5fQ<W ZZd d{(n!y- 8ce\cVpl8O{N_q~# 8k3|.en莛5;30gnyO%3Ҽ!mNc_6fRYx+B˚v-Z+Oq UunLOKCZA*΂*3'r(M֫#rۛmYxg&(+YhPH)5PѢ(G JyD.)Y=2o=4QEUWd˲ZPNZ Id9}QEYx^CuJh:].hbѧ8NTU9H$HƹNZoT[wk+m7VZom̞ʰ.1J@0"g[vO}P"F.RVSZ}cM<=r9K njgZknM:zfSXЖ[lUi.8V)4,^a?+)> d"[{mzϷƳϭ]aŌW2 5ED֧AJIq{%l.:xw]fF3Ҽ}ֺ$'oS43̋8V'g) +y0Zuzכu(f14K}bs=7,1h;xakbq@7| 3M>mFhɈyue =q=jmmP>e y5iRpbӠ1E^]lf1{U]ssJs|~ЂdǙAr.$\>9o'8ƣ \BoMWwgccA;4R8:T >pO1Vp))U6xF*)cXs //mƓ6]"Psm9myWޖŠsF Uo9rkk=zxMdp-1Ѧ [6z,m&e&q8<-\Rŝ\9X(|k|[Xk%^bBrGMHˮY}S[Wsmb7}Xa6\D/Genn8dKhɵOb1@ GI8|9i莓ּ(1̮SL:^,"Hj+EIGR F񵻖 c'5FIw.c^vIlY%= ;hZȃ0ECYeD{ʪ͏MSW,lwai4=@EYV(n%9B2EQ]9H#9QE%;Ċ$Eh(7XmilVwa8x$rHE2TEW.IsU8QETTp,"EFsh(ҙ$2iZMHE\D!EYkbb3 ;_E&wTռ4.SU%앟Z,6vwIhg&&5DۓʉT'YIm<Yڑ>z)h+F!tX--oԮX|YH(rNd̂UR%C](+rA' sBQE: :JBˌQEK)×锒i(Gp? hkYd}yW "N7-F+7`t"thK^PxUyR]kjZDAۤT:oQʪZL鳒45%]EKj;DTީzN[pr˥h8QQzm.S!v'2t[=}Y^&!zEĵ0"k56-ј_1y_gkWg3;sS^ac|vƨxK*ǍXK$y;jD51+r=|՗9ܘbY1}&#uͩǵJQ=5DԜiČh{-T5mM}Zk8g3Zxšo+ 'VvN' /]dvP+CHM^HיtY8Ϟҩ]'rIY~=AjJ HS*4jO)6wjYaWh!m1EB 5TN %DHK 2QE"S:+(ڠ@ԤA]Nvڕ%QE6娎rV֊(G3:Z1-QEW19UuG4(('(Mr vnh($V,5$s n(*]~DJv݊E\xԍ5%i/to Ͼ؆g⚴y"f:;WWn׳PTcI(HYs?J^I3^-l9z\K{5޺L8wI?*^#׭9 כut&HM]HU[%jy5.M—: zM1Lvc8\2Ӻzz*Ӈ Nki 4U~x rR`;QZҝE[x|>;oUv?ԣZ&{t4O4˅*9l//T]v#c3I,I6.o oNqJ񄵛yqTeʚÈ Qއd띶N. _?y.= ӡҋFݍiϞc4 *j'TtW)V^u^UsdkWL *˄N_y֩XӦR^a76VI:cutkz\O6 @".Yy|"=Ė'_ klr[ J¶۠+@}qSZʺоtM$zP^8zi *i~5AA@gB.u|j]197h- <3ɚķ>zMks̸6Sk.=J[#>)ϢϥMٝ:bE1q t>}#ګqF(Zq sb3Ɣ[@Ms>qq@E-NzaX8tpgڇvBKD%#h&HNҿӊ ;Ҟ>.w4MMUpkA o;Գp(ʚ±oHn44LJm.,]=**2WU^ێ]']|?Uэ#4UW&b3 nm2wϤ!q<#$ F`CE,t3ziڝ$ΆZRV|zgNb(|b|XQ<kn!+lzk;A4IHQ3dmWSZvrkWŸZX>jźn zHhYN6𭚆yL[js^/q-9SGYwƛ{B:g$#B90+K촶RELft'ր *ameLRmy-DKĎI3 R7rhxF3֒a˽GccJgg:ЅZ #Zf0=y|例p#H'u@$TNv!+864]8飸-, W5ʬD^N6KʸZrCY[LXqNs8)1D)kOjbi,޸'4Ms1S*uΘ^ -1f94]=>4Δme8k>c|<|kc>HogU+Ik͆&vI1Ә+H~kCmHK911$TTQEGu*Dɉb'$Tsebij/M%QS(H9Ȑ5*jp5Uqy)-[I4d&tҹĚm++H0sr{4'%DRMQ+NJe8q(`iVd ɴ|˫/:O úu\!q;PE$apu_~>׿l,,uD#WmDU8:o)!µR|kQ0kk_R.o49Ԧ3u[Q^OğK| +ɞ{ ~=/s:\ 5y%&kԲgoMyN yҶ[z黭"QZ%=9."MXA֮Ƥ +J+`{%=9|MgjeG\PEG7G7@kY̔7<iV[tfq@gJVقdRۦu}9$LʌIpc:cNp%4j/ᶅi kz%Ÿ ˉqպ'Jx,LUm8ђrN7S2;'ˉ<=tM-UdM]||M־z!5n}tk;{[bt5`O(aLFIEMmO)@䃖5}e0pc |4cLt 4w9#IH^`4zdc; CҢr3R#\4òïV~(M]m1]:jIHM6ڜ':b(6 n{u}<>YĜ:n|!s1EM3k-OyۼJra#oFDq863OmE]NkcWv4( Ҧqt=ndWLDg`6[mExwp q;VN7 Oo3ȺC'4 Dt4j?s-8Ѯj`UW[M6yUt5e8JY9|8b*9sid3{UeǼ摲ـ65Ϫ!.!s' _L hcἦ=G#z{1&|ԀVjkҭ,Y!3.ҮN @Wq4V'f.ފo(k ::Z8|L'IJhhN"NGH&<3^TV|8X컐eЉںsRE 1*-r(dMPqC74Qg8f&X_itǷY8J H,jB$U4nqdZx9 Z<[O^k/6uJig6Yb+'g5<^pKұ_OO+ELV xHk[8\ɍDo?@9ɶdVmT]}Zby5bv˚;3WH2n-hٜ1b q=O=]Q tv/)7:y2\@0:P2H, xSmדZA[8Hޗ,)GŶ`yNt,Ė%V}qVDFecgz%˰obgs; 1ɸvZp ix_^\Yci\֏-n%^Sw: 9D,6mť-'.Yj֮'í! ̝V,%'88Vk[-caC#)3cҧKk&gۗͭXcP55 fOUj٬ƚڮF7khEwYk}Zxm/mzwD4r8Ŧ W7^`` yc۩n?~+ޔ{oJ!g\Zw[]_ns7M&yUٯoV[{/j9)*'})@1}VÂ;)PRεO'5wZj).^i.6]m4ܻU]5VU]5z/b;Jby~>m+A{tkA4xֻ11Okߞ:Bg{Q[}T:QW;X b;O[8{UUUEi"kLv1|B}}+-z}}+/o*+kuPi@ hqb;q߂5uyѿҳ۷Jk)\T+,K0Dau oWW߇{\?v`(ҽS{[bdyZm Tqm95v>sTq}R؏.o%M07jw5ij]} G, cEo`5|*}(Iᢦ$ J%(pא׭)Jj7:x҂Um E_H Mm3>Q^{ BT-]gjuz)65 &+/{OԴغ\ܛغ#+ߕ6REZvLǧG~ ++( endstream endobj 1613 0 obj <>stream Adobed     '$''''$25552;;;;;;;;;;   ####''',,,   ####''',,,   ####''',,,c""  y!1A#Q "$%&'()*23456789:BCDEFGHIJRSTUVWXYZabcdefghijqrstuvwxyz!1AQaq"B2 #$%&'()*3456789:CDEFGHIJRSTUVWXYZbcdefghijrstuvwxyz?VdEh'IȁX!4<`@ 4d0 @4$hP55!e0b Mɠ4@4baP9r1!B` @qD ` @oH X` 0@8НV:Y154$< O0A &4$1 ha##H@4@L0$ ,&SXrbp#@hc%`-@1Ȕ0 &1B!- VhO`L! Ԡi)њY:IBo>#F !&!7`*p-udkXHof9`hƈB'qcXr%`E L85`;XVDH 쑝ft¥N7bV\P&t*T$LZR֎QiocXr&Cs4fFT@ 4ff7!&drhpa- ,E-Yp-MqɌY x'9R!brқ d5VH#+3KN@f7q 9CCF0ǎ (Xq&]*C @McL&i4ă¤w5e5 c@-qle@ (r&ؤDRPW1fK(Z@e )fH'q !ȤߌdV biI5t34Ȗ9yQy̍Xe5@]Ө2B@lPMNP0 DRVh 0 j@3 91l!L @$7lP@b) r `)ӛ,R7`@ JH+b3P`f !obyN5Z2@d 'i4BTZG3%շy3j:v2XgKSciʺUzq{L&Sh+$5B>z%ٺm8yJMFz[DMVi$eZ I2\̶f^9NU)R!3 nۇիtWGZesYx֛=&꫰V^Djlytl˭n6Kfb^Sc.ii*GZͨ.+fvFVXUu"ry#ɣ)#lb3{IYpWVRW^0tSTd ojY"J,HiY9-A\-:ݣ*.G6mE43݈jSsiɠ@$VKRlP44( pr0ŀ )Ԝ0:iR&&QmjL5hP&'+ pM@+ȕY @k33DxnM& f,wn3!,7}onh_F,OFZ=%GOL.of"hۻLUKThhh0g8ƴ)JMz'K>ETu!uM{/aGmL*tr%j!f&)XjUF }Upy -Kiۮ9[Yxqy\E*k yQCI',r!V<ݫqGnrddڬeqYofBeM$'n]_$yosI& =ML=#S >!%{3yff#f՜ՙx&)\, I*E:8Hhk :[U3BCKE1YIxJh"=UU8ffWT'k]E9%˻qbڙ)Fui5U4nI%li:T,FV>SӢ]0STWR:a­YLJUwvŸ3Iؽ3iiGbR7O].): KYR]ShxM;t\&qu} JzԞvY^ ٷfbr>.CVMI61| )cgMU4fN!fy4!aBE(NT$ MeY\EMRf[6\ԩꁩ=`c&Fu\F$՜֝%jq$ti:ĩ:3ʕFeuQeQa3H5s$JLhM*p+`'s.Oa6&әMM6wA&HRcI]4R٤5̴ MLcs16)=lI]MTӐ¹ QG70y)NQ[M4I%Yg ܯ^r38} jnaxB:&4Uu&n[>nS - *駆*i+pB%It}pSa2.51Z_iK|&n*Tt >qS:z#==%`0Iiv]Ua 6U)PLI,ZRM1!WU'gcmYbij)4=AfgG]MZTŒg hx>O^lkӦduVzt*fSZz((zխ.= ^Vm=c3w|vlٱf,وf#FHzfny6\s:~ûxtAKBrR6Gx?lD=j6R$SJXdqvs.[oѺ1]c\{Y΅f'J䘍75Nfffk3,u}\Gޒ.jTN-ZEJ[%^8{v:44o25TѶmM(`DZIʜ6Xٚ1ø <"Z4m5EWv:)R/dzWKwm:Nh-DկOb"{Qj-cs]Z*5(iߪpNNRRZhut(MU=PAL}C)ՖYZ֨6-d Vwi39N2M"X33 U'X4"t1oZE+1&&֝,Y($t6 QE*F6FDM$jhQQVb.!eJ$ IÀ5(R1XdMmQĖ&-Ec)3KOpIoy ^k"mX:hz9/'KJ \+m8>Դ Եefvu˰. Lפn[sŶlΙͫȳ99x^W+F95SN&$ze<ڬΚ vYxZ{4 eIWV{i4\ޚ16ޕuZX6ɫE\'I%48qU9[uijաKvzl,:T=ZoSx5z=IM4UJrpG8fm7^zKe$vhxh4*)[1okyzm5zzzJ%,D*ؚ9#&ݩZ6%]ia\fzdϝU[>t궚5\)uWokW2o+Qh,,zN/>]|.m MۜaEi%_ J i8\<p`Bp6UPIœ(ryt.`x#Ǩyޑ3hڥ믅Uܛ9viN<(ҀSJ41qMY_N5Pu%abkjP-z&ۧz]>BmR} W t$7M:؞ţoZJR6Ŭ̽ۛǢŹ/ Lb4vGJG'8.bduo51t7p͝Gi5\ VDVg BF#-,g"f)Q`*!7qJhɚEi>\Qaɳqi3=XѤDH-E&9m0IcМ$t%MJ   mD4`6NɗkZo!ڢMr܅ZDaSe QLy46Y7V+O[Z<ǑR:Z>Vr>mS<K;vF&URN־ͦjeURNZz9MiIkઅMtfDkֲ[w{L*O]Zhʲ< T++]pZcF-p\EQs V2K#X<43E1д1uZP1Q1tѭgDI]%T5|wurb9A):Uvҷ0H$EIuf5cKR3Q^}贎kbʵi馕5$$ϭ_ 4OWb#.zP@ל^DMj(%*칰 is3BY칷L)JâpM&ӎ vݩ1kf) DGO{Ph\͢pMNk])=j53X@yuo dڮg^RoUUlZsn,ی9Ow i.GӢW9tRݠӪ^nQ+gױn7ΫDp7'NV#v<-.6b̒صLY 0 QW&k%b*cCv6)3y#K#1ķ5,̴5-ќHI,,MÆ,Ɏ-Ko!h{ TF+yլr۷f,Ly:< wyZt}ҜTLKVS㗿AQs-ڽgRjU=6miİzѤ"i.!^O5ZDY<[oT[fUr>*Pq9Mmkݏ65's (i﹘ҤÔ&:F*emҥhƵM@xԛQG:Je:[5TkM:^">U]Zz؉rUFn^HQRuRmNJFee!,yFUSU`'JPhtRUL¦1=j2FU:%_Dm,kOU]{UT "i:@*sh= T*y9] [qSi'Ԩ4ԞVO7MKN,t]W-ɾ= 4M*l8թ)CZ<{f UZxs Z :WLCUYylcblo"G^ni:Ӄ8R} 4긌lsiW>JM9'Z9+=].X>cbz-49ӑI&(M8$DJc3jfti*|ֶDUfXNn썮kIxqb+ej :EX5Ҝ 4@FL8GRZJK\X-♣yؼGnq̾ZѶZcŦrSkXiqZs39#I<]#U,Jv#M[m 5Bsr]ryhgi@ WvUaM];t=[F c-z*^I9ON/=.A$ڵLllFjjtPMJhWbRi^'LjoږRX0a\ j"6TIZ 7 qfN8*`z5ʹ*jsTCV` VqM5*= z]#SϥҸ[ $4d6MI-sIdKè;qQZϦ(S=y{zlʅaZ*,]r)x4>i(>O6GJLKfbbm,pW@xvM豥m3U:j1SL56GpTrT]͈yg5f2M*ڙd oA5zZ2\G>WZZZ xp_CKZtoISWi&M Ԫ.3Nm}pݪWs<Si(ˤwD(5DC\΢u UEyî؛vXof5j@c kI#nWT*4ja$OhM(J=YjY-ǎ\Vg*4o|Of{Z^T!)rk6y3qڵSMi)֒5@UNO.Gؕ,RdtCLe6frjaً1g%+J{xFUVdx]:ݞWv,۵KV:c34s0T&tu`>kҞL5V_\ͬͩ31]5qjͫ4E+鉂fg,'LYhtjtURz4Zj4׆*&ZToGM:uu]g ]uQKstUU ,=mjaNu90k15MژΦj-5ꡭ"NyK::K=UORTN.]Xjى3.Hg]ͮW]+Xh^I_CUU^ŏZSObYbvhYo7U(=”>ĥlE`n!k8x-,\LG l=:NiL Lړ5,&&[kkIylN5njJ˖խM UjoTiC]d:[:+2̰zjV4UI;>"Ui*xG):.Ԝ3Xr G GUd`i07&kRRLzv^Ӽ_WLTx4R>f+[LϗN}zpkZb`zIs>^k ФG|wّҼ܏^9x3xH0GELkԢ0hl[ Pq#Xԡ"ccѭK>^HI)Тm  u*9GNƪƬ\ C-LD \NYbgIءj+$9̀3N8͚m *J8EUvN Vtrf(BtJaLkCn5h Y~M5s ]pP1Ws_ڌkIȏ tt:iVo,BVGiX3\{ ;0WEVy[nJYliFuԝ#Em9枒f\J*ӥ--NjI/6xXPV2US# OEt-Yɇ/QSo εNݞڜ;p|"^ u)֦zR8?*tUibڈmˤ#n鵬c|EZ:晶WjcÉf|ORՅʒSxbj1*K>Iff\8cej6=Pf˶'ϢG,x3(:cDYe4*SY aJۛ0k=SS.'j !SG| cLksm2#N:kn3R(q ]#FpyM%ho"oLgT}])vLU[ۦgTSJ19ka.Ɩ(VB< 5j,Neogz:'qeNwghny }jsq8Mڵ6Mjf{l:EiE4ЩZ.I|뮹֩n>3U*rFJi7Kt˵0W90xR$cBh Ua4eu6*$`F@mʳi:O^1{dyuU.iӤ`' ٬ hMMQezEKn8U(J5KN4nW0k@WYqy"w4pzuS[Yn:4m X3pU)q9 4SMN36۴J\Kqex9I:] -+dm%cZ׭v &i̸ 8F&ݡAijWh fq9Af+qc @v34n& LGu(Vh)a wYsWvlۈqj&'39fynrLw7x:]^ө7'"%VZ4T4ҪBSK5lI9 },V+h®gU1nqZZ5frBJ:c)lbXi85t7u9YQG^tf;S8!q49ff&&21@z:])*$\x.hp^itԻEZ: o[éc:F7,fXBO14_EuNU5SjZNYƂ3zgdpOaT,.o1ӥiRn{L{Ӷls8䤶& +]>2Nva*@5T.o`7fPל0V .='i&I`;cXJ5ox X^Zoi.[:u&iSTՊN^-5QZUS]-:^ ;4x8l 9TUS:JT>ʞIn3zumؘpjj(/_Gp/NxxFTP+;Yl<'@[Av&9iI5:'Kr'*.u|/jN8ha;$pCzr)*P^E1Id&,7K`L-P.yɅT`-lYl%-KYxaռ€^ HUYW=6X5Ӫ*nfYSw6)umW5Nó&r$ ƓHܩX;<2Jti{(ɃXMZjv)=))Nc#Ŭ҅}kM-tܜNp=}"&M%(ZmYQkM9ίmڈNHqY@GpZӃ[N K։}ص\DzJd itҝV a3`YgyU:^U1KƦoQJQZ;Z-%]OVݑIJZ-Z)[`*1wi$l;w'IlcF*ñg S;Eё3g>Ng%qT 'vjv%zM_=:+Kf<>}hˋY,-% ym+4U8uʄ{uwIJ""^bIyn-[Y6rqyf,ۘQj2I{σ E^USdMwMPkt=-_T֛]mEU:SKaU<]S``il"Jȭ00lEyΗNUSKZfbU9jƁ :4*CjǎJmEEu4%Hwuc/2*iڲ =IN2V `М$'` l@݃2C381ͫ1j1àӀ2UJ,QLX=sGj&bՈ 0d=Js#tvvhӖ|~)>D9&W0a C͟?IJVgI&U_υ4z15m\CUq"bY]>RfjH j*Rk$&Y;";K 7ж¥Qu#E!5PPZybũg0hʃY⅖=PQDZzUIɽ&7V뷋¶CC߳"L=ٵjŨg,deVLڵ5-`Ufr/Th֪PYlO0 eTՄdتT8mK+ tmdڈ]`oY7(&j 8E(h`k<^M8CYgB[kz&ӗRi4m+$MU)0a=RZ 2j)%2y[9[ L՝*6igrzז s4ygPq\I @fnenxG)'Ld(4Z&Q 5`F:}\\`m7,c1ji([vnQUBIRۃTiKL&il%HEԞdY*qzUAPD#VZiQzIUM# fx1&,eȥIm&ѝ1 :eG)`N X+yp)*B6X`ghk-H4e b{u3y-Ea+tVMSf4H6mc8{UM')Z'Жi\G-K̶d_tSApztNScT*eP0ھ59%=W{4Ksj5\Drzhv^GL/V驌_ӷ" 2X']Ӡ݊U(c=* )钦U-eo8ĸsS_E ؅ti~IxhZ,Ԩ'Mz 9dOUsWD_]IIh"!{S[Y3US+8e0Kl-*&ªqesRެٳ(Tzi-&lGJ/]Z6ƵMnŞGں.4vdm|"TUN yJ U4ee=XPfw+l¼9`&+1d6,6,ڷ43 $nSST8#&TCMRB/\(kT @˙-NQ&ۺT͇Q4r)KXG*p%R'i;J:FWL9eݩ9 c2{H-fr55Xg,/W!EP;jxӜcL!c1HNFlP`+ [IŸzyOf\ZCMbV<}UJI4{GIx؊U413-Mxt*l>F!]`SE^Lp ;%t|Nhf+#:'3#F Hkқ\Aib#5BQ{H4dͳRj $j%6]͸٨J(VkiS3 /< 6+ѹ%ۈz6K#]zMeM4L>5SU.,2Էxrl/LhX&ڔDZ`iZMTkـtf*hƴ6X]fe8bZ2C؜Չ<9kIӇJ))m#RN{Pa3M6Jljgji_Q42Pvf"kY5pz0&լ&IIb1\(f T1khcFLfpUTpKUnԜ U:a1c `%!;H5!ȣ&f R(hЋS.&fJ5ЕuU&ܔM`͡X/ 1ҁ0cb1R&ڱ\&걍'Vm`"UQ8z)W,r'{qfRՙ*֬D7}q38t=Z2t:]p۲:PxxGUc2hҪԫ8m'x+".' T\ZMQF HMK,FӴD81U;  *Е-jﱕZP`"4FR6fPKT 05[N[IN&el>[֧rFiFkĹXA*m6>stream endstream endobj 1616 0 obj <>stream endstream endobj 1615 0 obj <>stream endstream endobj 1614 0 obj <>stream endstream endobj 1605 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.091 Tw 10 0 0 10 70.8661 724.8299 Tm [(\024\022\024\027\004\026\027\017\036 \f\024\023\030\024\r\024\032\007\026\ \035\024\f\034 )0.5(\027\026\004\026\035\024\n \r\036\027\024\027\024\005 \235\026\t )]TJ 0.16 Tw 0 -1.218 TD (\017, \f\024\024\021\r\036\021\f\021\r\036\027\027\024, \024\022\030\026\ \001\017\r\026\027\017\036\n \r\036\027 \017)Tj /Span<>> BDC ( )Tj EMC (\n\026\022\f\017\n\026\035\034)Tj 0 Tw (-)Tj T* (\027\024\005 \235\035\033\024\030\036\f\006\036\027\006\017\036\005 \(\217\ \017\f.)Tj /Span<>> BDC ( )Tj EMC (2\2264\).)Tj 0.328 Tw T* (\211\004\017\021\t\r\026\016 \022\024\035\017\004\036\f\021\r\024 \017)Tj /Span<>> BDC ( )Tj EMC (\030\026\f\023\024\035\024\032\036\027\017\036 \007\017\f\021\026\035\034\ \027\t\b )Tj -0.012 Tw T* (\r\036\021\r\036\005 \023\030\016\n\024\022\017\001\036\004\027\t\b \026\ \030\021\036\030\017\005, \024\021\n\036\004\026\035\017\f\034 \020\030\026\ \027\017\006\t )Tj -0.031 Tw T* (\253\r\t\022\030\026\017\r\026\027\017\016\273 \035\024\f\022\031\021\026\ \021\026\022\017\n \024\002\030\026\024\n, \004\021\024\002\t \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017)Tj 0 Tw (-)Tj 0.16 Tw 0 -1.218 TD (\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (3-\n\016 \007\017\f\021\026\035\034\027\t\n\017 \r\036\021\r\016\n\017 \023\ \030\016\n\024\022\017\001\036\004\027\t\b )Tj 0.085 Tw 0 -1.218 TD (\026\030\021\036\030\017\005 \r)Tj /Span<>> BDC ( )Tj EMC (\006\036\027\021\030\036 \035\024\f\022\031\021\026 \027\026\b\024\007\017\ \035\f\016 \024\007\017\027 \f\024\f\031\007, \026)Tj /Span<>> BDC ( )Tj EMC (\031 )Tj 0.162 Tw T* (\023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (4 \017)Tj /Span<>> BDC ( )Tj EMC (5 \r\036\021\r\016\n\017 \r)Tj /Span<>> BDC ( )Tj EMC (\021\022\026\027\016\b \235\024\030\n\017\030\031\036\n\024\020\024 )Tj 0.099 Tw T* (\035\024\f\022\031\021\026 \027\026\b\024\007\017\035\017\f\034 \007\r\026\ \002\035\017\035\036\032\026\013\017\b \f\024\f\031\007\026 \023\024)Tj /Span<>> BDC ( )Tj EMC (\023\036)Tj 0 Tw (-)Tj 0.316 Tw T* (\030\017\235\036\030\017\017. \221\035\036\007\031\033\013\017\n \220\021\ \026\023\024\n \220\035\035\017\023\f\024\r\017\007\027\t\n \030\026)Tj 0 Tw (-)Tj 0.369 Tw T* (\030\036\024\n \017\f\f\036\022\026\035\024\f\034 \027\026\030\031\032\027\ \024\036 \024\021\r\036\030\f\021\017\036 \f\r\017\013\036\r\024\020\024\ )Tj 0.232 Tw 0 -1.218 TD (\b\024\007\026 \007\024)Tj /Span<>> BDC ( )Tj EMC (\r\027\031\021\030\017\f\235\017\027\022\021\036\030\027\024\005 \004\026\ \f\021\017 \f\r\017\013\036\r\024\020\024 \b\024\007\026 )Tj 0.388 Tw 0 -1.218 TD (\f)Tj /Span<>> BDC ( )Tj EMC (\023\024\f\035\036\007\031\033\013\036\005 \036\020\024 \024\002\035\017\ \021\036\030\026\006\017\036\005 \n\036\021\024\007\024\n )Tj /T1_1 1 Tf 0 Tw (FiLaC, )Tj /T1_0 1 Tf 0.314 Tw 0 -1.218 TD [(\035\017\002\024 \023\030\024\001\017\r\026\027\017\036\n \r\027\031\021\ \030\036\027\027\036\020\024 )0.5(\f\r\017\013\036\r\024\020\024 \024\021\r\036\030)]TJ 0 Tw (-)Tj 0.209 Tw T* (\f\021\017\016. \205\024\030\n\017\030\024\r\026\027\017\036 \035\024\f\022\ \031\021\026 \027\026\004\017\027\026\035\024\f\034 \f)Tj /Span<>> BDC ( )Tj EMC (\030\026\030\036\026 )Tj 0.243 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\017\026\027\026\035\034\027\024\005 \024\002\035\026\f\021\017\ \017)Tj /Span<>> BDC ( )Tj EMC (\024\007\027\024\005 \017)Tj /Span<>> BDC ( )Tj EMC (\002\024\022\024\r\t\b \f\021\024)Tj 0 Tw (-)Tj 0.1 Tw T* (\030\024\027 \021\026\022, \004\021\024\002\t \001\017\030\017\027\026 \017\ )Tj /Span<>> BDC ( )Tj EMC (\r\t\f\024\021\026 \035\024\f\022\031\021\026 \f\024\f\021\026\r\035\016\ \035\026 )Tj 0.332 Tw T* (1/3 \024\022\030\031\032\027\024\f\021\017 \023\030\016\n\024\005 \022\017\ \001\022\017 \f)Tj /Span<>> BDC ( )Tj EMC (\017\f\023\024\035\034\024\r\026\027\017\036\n )Tj 0.159 Tw T* (\024\f\021\030\024\005 \023\030\036\023\026\030\024\r\022\017 \017)Tj /Span<>> BDC ( )Tj EMC (\002\017\023\024\035\016\030\027\024\005 \022\024\026\020\031\035\016\006\ \017\017 \f)Tj /Span<>> BDC ( )Tj EMC (\r\017)Tj 0 Tw (-)Tj 0.167 Tw T* (\031\026\035\017\026\006\017\036\005 \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\b\030\026\027\036\027\017\036\n \r\027\031\021\030\036\027\027\036\ \020\024 \026\027\026\035\034\027\024\020\024 )Tj 0.331 Tw T* (\f\235\017\027\022\021\036\030\026. \212\017\f\021\026\035\034\027\026\016\ \004\026\f\021\034 \035\024\f\022\031\021\026 \235\024\030\n\017\030\024\ \r\026)Tj 0 Tw (-)Tj 0.11 Tw T* (\035\026\f\034 \023\031\021\036\n \023\030\024\r\036\007\036\027\017\016\ \023\036\030\017\026\027\026\035\034\027\024\020\024 \030\026\030\036\ \026. \212\035\016 )Tj 0.249 Tw T* [(\024\006\036\027\022\017 )0.5(\022\030\024\r\024\f\027\026\002\032\036\027\017\016 )0.6(\035\024\f\022\031\021\026 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 15.506 0 Td [(\026\r\017\f\017\n\024\f\021\017 )0.6(\024\021 )]TJ 0.207 Tw -15.506 -1.218 Td [(\036\020\024 )0.5(\001\017\030\017\027\t )0.6(\023\030\024\r\024\007\017\035\024\f\034 )0.5(\023\024\r\021\024\030\027\024\036 )0.6(\r\r\036\007\036\027\017\036 )0.5(\222\037\003 )]TJ 0.013 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\007\024\036 0,25 \n\020/\022\020 \f)Tj /Span<>> BDC ( )Tj EMC (ICG-\026\027\020\017\024\020\030\026\235\017\036\005 \f)Tj /Span<>> BDC ( )Tj EMC (\023\024\f\035\036\007\031\033\013\036\005 )Tj 0.093 Tw T* (\r\017\007\036\024\235\017\022\f\026\006\017\036\005 \007\035\016 \023\030\ \024\r\036\007\036\027\017\016 \b\030\024\027\024\n\036\021\030\017\017 \ \r)Tj /Span<>> BDC ( )Tj EMC (\031\f)Tj 0 Tw (-)Tj 0.093 Tw T* (\035\024\r\017\016\b \f\n\024\007\036\035\017\030\024\r\026\027\027\024\020\ \024 \002\024\022\024\r\024\020\024 \006\017\030\022\031\035\016\021\024\ \030\027\024\020\024 )Tj 0.18 Tw T* (\026\030\036\f\021\026, \f\024\007\026\027\027\024\020\024 \027\026\035\ \024\032\036\027\017\036\n \026\032\017\n\026 \221\026\021\017\027\f\022\ \024\020\024 )Tj 0.314 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\022\024\027\021\030\035\026\021\036\030\026\035\034\027\024\005 \r\t\007\ \036\035\036\027\027\024\005 \f\021\024\030\024\027\t \035\024\f\022\031\ \021\026. )Tj 0.367 Tw T* (\207\024\022\024\r\024\005 \006\017\030\022\031\035\016\021\024\030\027\t\ \005 \026\030\036\f\021 \023\030\024\r\024\007\017\035\f\016 \f\035\036\007\ \031)Tj 0 Tw (-)Tj 0.183 Tw T* (\033\013\017\n \024\002\030\026\024\n: \031)Tj /Span<>> BDC ( )Tj EMC (3-\b \023\026\006\017\036\027\021\024\r 1 \020\030\031\023\023\t, \026)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\032\036 )Tj -0.027 Tw T* (\031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r 2 \017)Tj /Span<>> BDC ( )Tj EMC (3 \020\030\031\023\023 \030\026\n\036\030 \035\024\f\022\031\021\026 \f\ \024\f\021\026\r\035\016\035 1/3 )Tj 0.125 Tw T* (\024\022\030\031\032\027\024\f\021\017 \023\030\016\n\024\005 \022\017\001\ \022\017, \026)Tj /Span<>> BDC ( )Tj EMC (\031 \024\f\021\026\035\034\027\t\b 3-\b \023\026\006\017)Tj 0 Tw (-)Tj -0.035 Tw T* (\036\027\021\024\r \030\026\n\036\030 \035\024\f\022\031\021\026 \f\024\ \024\021\r\036\021\f\021\r\024\r\026\035 1/4 \024\022\030\031\032\027\024\ \f\021\017 )Tj 0 Tw T* (\023\030\016\n\024\005 \022\017\001\022\017 \(\217\017\f.)Tj /Span<>> BDC ( )Tj EMC (5\2268\).)Tj 0.273 Tw T* (\215\024\f\035\036 \023\024\r\021\024\030\027\024\005 ICG-\026\027\020\017\ \024\020\030\026\235\017\017 \031)Tj /Span<>> BDC ( )Tj EMC (\r\f\036\b \023\026\006\017\036\027)Tj 0 Tw (-)Tj 0.244 Tw T* (\021\024\r \235\024\030\n\017\030\024\r\026\035\f\016 \022\024\027\021\030\ \035\026\021\036\030\026\035\034\027\t\005 \022\030\026\005 \035\024\f\022\ \031\021\026 )Tj 0.182 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\007\026\035\034\027\036\005\001\017\n \027\017\r\036\007\036\027\017\036\ \n \023\024\035\027\024\f\035\024\005\027\024\020\024 \035\024\f\022\031\ \021\026 )Tj 0.061 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\036\020\024 \235\017\022\f\026\006\017\036\005 \f)Tj /Span<>> BDC ( )Tj EMC (\017\f\023\024\035\034\024\r\026\027\017\036\n \001\024\r\027\024\020\024\ \n\026\021\036\030\017)Tj 0 Tw (-)Tj T* (\026\035\026 \200\017\022\030\017\035 2/0.)Tj 0.188 Tw T* (\200\024 \r\030\036\n\016 \030\036\021\030\024\f\023\036\022\021\017\r\027\ \024\020\024 \026\027\026\035\017\026 \f)Tj /Span<>> BDC ( )Tj EMC (\b\030\024\027\024\n\036\021\030\017)Tj 0 Tw (-)Tj 0.319 Tw T* [(\036\005 )0.5(\r\017\007\036\024\026\023\017\f\036\005 )0.6(\024\006\036\027\017\r\026\035\026\f\034 )0.5(\026\027\020\017\024\026\030\b\017\021\036\022\021\024\027\017\022\026 )]TJ -0.022 Tw T* (\023\030\016\n\024\005 \022\017\001\022\017 \017)Tj /Span<>> BDC ( )Tj EMC (\r\t\007\036\035\036\027\027\024\020\024 \023\024\035\027\024\f\035\024\005\ \027\024\020\024 \035\024\f\022\031\021\026 )Tj 0.183 Tw T* [(\023\030\016\n\024\005 )0.5(\022\017\001\022\017, )0.6(\r\t\004\017\f\035\016\035\017\f\034 )0.6(\017\027\021\036\030\r\026\035\t )0.5(\n\036\032\007\031 )0.5(\r\027\031)]TJ 0 Tw (-)Tj 0.279 Tw T* (\021\030\017\r\036\027\027\t\n \r\r\036\007\036\027\017\036\n \222\037\003\ , \027\026\004\026\035\024\n \026\030\021\036\030\017\026\035\034\027\024\ \005 )Tj 0.333 Tw T* (\235\026\t, \b\026\030\026\022\021\036\030\017\031\033\013\036\005 \017\ \027\021\036\027\f\017\r\027\024\f\021\034 \026\030\021\036\030\017\026\035\ \034)Tj 0 Tw (-)Tj 0.106 Tw T* (\027\024\020\024 \022\030\024\r\024\021\024\022\026, \017)Tj /Span<>> BDC ( )Tj EMC (\007\026\035\036\036)Tj /Span<>> BDC ( )Tj EMC (\227 \r\036\027\024\027\024\005 \235\026\t, \022\024\021\024\030\026\016\ )Tj 0.138 Tw T* (\f\024\023\030\024\r\024\032\007\026\036\021\f\016 \n\026\022\f\017\n\026\ \035\034\027\024\005 \235\035\033\024\030\036\f\006\036\027\006\017\036\005\ , \021\024 )Tj -0.017 Tw T* (\036\f\021\034 \r\030\036\n\016 \007\024\f\021\017\032\036\027\017\016 \023\ \024\035\027\024\005 \023\036\030\235\031\017\017 \f\021\036\027\022\017\ \023\030\016)Tj 0 Tw (-)Tj T* (\n\024\005, \004\021\024 \b\026\030\026\022\021\036\030\017\031\036\021\ \r\036\027\024\027\t\005 \024\021\021\024\022.)Tj 0.959 Tw T* [(\222\027\021\030\026\024\023\036\030\026\006\017\024\027\027\t\b )0.6(\024\f\035\024\032\027\036\027\017\005 )0.5(\027\036 )0.5(\027\026\002\035\033\007\026)]TJ 0 Tw (-)Tj 0.372 Tw T* (\035\024\f\034. \212\035\016 \026\027\026\035\017\026 \002\035\017\032\026\ \005\001\017\b \017)Tj /Span<>> BDC ( )Tj EMC (\024\021\007\026\035\036\027\027\t\b \030\036)Tj 0 Tw (-)Tj 0.494 Tw T* (\031\035\034\021\026\021\024\r \002\024\035\034\027\t\036 \024\f\n\026\021\ \030\017\r\026\035\017\f\034 \036\032\036\007\027\036\r\027\024 \r\024 )Tj -0.002 Tw 23.244 64.543 Td (\r\030\036\n\016 \027\026\b\024\032\007\036\027\017\016 \r)Tj /Span<>> BDC ( )Tj EMC (\f\021\026\006\017\024\027\026\030\036, \026\021\036\n \022\026\032\007\ \031\033 \027\026\007\036)Tj 0 Tw (-)Tj T* (\035\033 \027\026)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\021\016\032\036\027\017\017 3-\b \023\024\f\035\036\007\031\ \033\013\017\b \027\036\007\036\035\034.)Tj ET q 303.307 522.479 221.102 140.919 re W n q /GS0 gs 221.1023475 0 0 140.9197432 303.307086 522.4788211 cm /Im0 Do Q Q BT 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf -0.041 Tw 9 0 0 9 303.3071 511.6542 Tm (\022\t\217\210\b\002\220 2.)Tj 0 0 0 1 k /GS1 gs /T1_1 1 Tf ( ICG-\026\021\202\025\n\026\032\004\025\024\031\013\024\n\021\025\013\026\ \033\032\002\003\n\017 \013\025\001\013\025 \t)Tj /Span<>> BDC ( )Tj EMC (3 \030\025\t)Tj 0 Tw (-)Tj 0 -1.2 TD (\024\026\023\022\021\020\003\025 \027\031\024\027\002\003\025 \033\032\002\ \003\n\013\025\001\031\006\021\020\004 \026\032\024\031\032\025\017)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.007 Tw T* [(F)-16(igure )0.5(2)16(.)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf [( )0.5(R)21(ectal )0.5(v)16(ascular )0.6(netw)12(ork )0.5(with )0.5(3 distal )0.5(branches )0.5(of )0.5(the )]TJ 0 Tw T* [(rectal ar)-39.9(ter)-37(ies \(using ICG-angiog)14.2(raph)12(y\))]TJ ET q 303.307 307.088 221.102 161.663 re W n q /GS0 gs 221.1023475 0 0 161.8056325 303.3070555 306.9445778 cm /Im1 Do Q Q BT 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf -0.041 Tw 9 0 0 9 303.3071 296.2881 Tm (\022\t\217\210\b\002\220 3.)Tj 0 0 0 1 k /GS1 gs /T1_1 1 Tf ( ICG-\026\021\202\025\n\026\032\004\025\024\031\013\024\n\021\025\013\026\ \033\032\002\003\n\017 \013\025\001\013\025 \t)Tj /Span<>> BDC ( )Tj EMC (4 \030\025\t)Tj 0 Tw (-)Tj T* (\024\026\023\022\021\020\003\025 \027\031\024\027\002\003\025 \033\032\002\ \003\n\013\025\001\031\006\021\020\004 \026\032\024\031\032\025\017)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.005 Tw T* [(F)-16(igure 3.)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf [( R)21(ectal v)16(ascular netw)12(ork with 4 distal branches of the )]TJ 0 Tw T* [(rectal ar)-39.9(ter)-37(ies \(using ICG-angiog)14.2(raph)12(y\))]TJ ET q 303.307 122.596 221.102 130.788 re W n q /GS0 gs 221.1023475 0 0 130.8368917 303.3070555 122.5472083 cm /Im2 Do Q Q BT 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf -0.041 Tw 9 0 0 9 303.3071 111.7959 Tm (\022\t\217\210\b\002\220 4.)Tj 0 0 0 1 k /GS1 gs /T1_1 1 Tf ( ICG-\026\021\202\025\n\026\032\004\025\024\031\013\024\n\021\025\013\026\ \033\032\002\003\n\017 \013\025\001\013\025 \t)Tj /Span<>> BDC ( )Tj EMC (5 \030\025\t)Tj 0 Tw (-)Tj 0 -1.2 TD (\024\026\023\022\021\020\003\025 \027\031\024\027\002\003\025 \033\032\002\ \003\n\013\025\001\031\006\021\020\004 \026\032\024\031\032\025\017)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.005 Tw 0 -1.2 TD [(F)-16(igure 4.)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf [( R)21(ectal v)16(ascular netw)12(ork with 5 distal branches of the )]TJ 0 Tw 0 -1.2 TD [(rectal ar)-39.9(ter)-37(ies \(using ICG-angiog)14.2(raph)12(y\))]TJ 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\033\030\031\030\213\b)-20.9(\035\231\213\233\t \021\032)50(\b)42(\032\231\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj -51.938 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 23, \023\0221)69(, 202)69(4)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 23, \023\0221)69(, 202)69(4)]TJ /T1_4 1 Tf 25 0 0 25 28.2026 56.0378 Tm (94)Tj ET endstream endobj 1606 0 obj <>stream Adobed     '$''''$25552;;;;;;;;;;   ####''',,,   ####''',,,   ####''',,,&""   !1AQa"#2B $%&'()*3456789:CDEFGHIJRSTUVWXYZbcdefghijqrstuvwxyz }!1AQaq"B2R b#$%&'()*3456789:CDEFGHIJSTUVWXYZcdefghijrstuvwxyz?Bȼc@ !t4IУAd a ȪIW0 CB6Hԑ>!6L -`HQ1e8ީ4NP8[&i&6tXIExB Y0Fi2YĄd&8DQCHVMa$^ ,}c2@x%EZb]lV|\#(Ba+1pk\DH&* MiHAX0]>ltZ+`oG {X:JeΆ[yٳn"&ϴI KtDY:WI v %mWb ;ɁH$D6U$ihJC%@&[5*c:[ Zr<3-=U%KuUM>ƍvUe ZqP݁<xӉX[攎 H)! AA3N ,I4cH)B$)*+BJD( (%:@@(JƼRmH C -7R# <ȘTeݨ"l˳_J54:b驌B م@I^t]H b^~`W H$` &0 E )4 S "PlsQR bB* 4!8!MJ i4$Y 8mHSZ r^ 5  Iz@'[E 4Qa$]%PfU㽌i'YZL;V1DѮVE–Lu@Be GZS DD CH k*$N! tQpM(@meƠ) B",,`P CsdJZ<)`FP Y[. $Y^J8@ $HXXAf.qtɀ ݜA6 PVi5Wp4"EB6$ I`% ^02tYHii";P *XU;h6nVT"9rw ,ZaUS{ B!AUFJ08^aBGYmPpqCtɂ`t*Y(RL$e8!Dy#ФBU 1Z:cq^Ɛc 3Ym3FGFp1Eq7-@LHBj3%AdZ+lT -Xcegה I2PaV%VZ4j.SP`VyS\M9))5dRk<@(0޵l֕@ C`U^P`V1ՍBT :샖nhyA$^=#>/6ZEV|{(ҮVELPpOZl)4BbAByD(FɃ(HUF h|.!HDb(H5HH`(R TnU7@_04B `ၣ7Qy;QT k3dVB5Y\nh'US\a]2sꁈ`^QH.n2L[ "$vEg{`Ye %I IRN2a%55 d LЬ0BHBI85 [K "-ŘNBK9&cMTЄ!MKLmj ;0!X DKˊX ҉&k@nLDf-Z(A4DMTzGJCBD)@4Ib;kY "V0Tק{c+a z)kMuذWDڎj`(ĠP(b95~4φҵ0_I fXVKh26EP{cBȐ&ӮVE&)%'N*!4*@dR($FYV hQ$Y(S1H`)Fm7ID E ٍh%Z!s(T(MZ~;c4+3+)Lh!j{Åh H"vPhH(m: S<:ZRu,5C"("M<)#ӍեA([UInIKk.T` '6dmt! %S ψZufy;S%DLdIWF R.p iM1fa48k/T0LN=uII:!RiT1XgejI4eq Q4fYUz j<mf!m*i 7X9ȒdQP! 1XTCV-+p*!XԶМ-zZ 4jEJKP5U6Z-;%9`c;j˰ n$AO+`BA Y@際j5\ qBr5!4bTt"fJ:] mLU%**$Jq ')I%Pm28Uڥ D)5xn_E`,͒`C4DzB*.P] @%1(T6 Z/mnXShH-8.ikY,1 0qUxԮE΃TLBKؐ)t!J!@!HQ 34Tn5Dj`Y(.EI1d*QT(Mp$ $`JhܪL'0V<\#T`JP86S>gH`[6RX(~S1&Y2ײi+Xv9Xe34n[7A(N)<^ym(dO.bCVxW{NvgD6iJ܅t\_ @jI+>4e$Kf+ gKAҢ}5c`LMGgX!GUZ*f[F-kY6}bG6p~=s8go<ƻ^7xG,r mQ=)lSe$k?ȓrdXZ&36f M,e:=iȺZV෹R*(' TZoTheYvd6q0&3p\?IÓWRK:GAwEvVNV5)u98.naT1  w;IX3BX6YqXT!!ӡ= !7Zb6= CyByࡥᎏ9A!^'kE^Rߓp Q@brrєm-6En,v& J^)gFkFrƮJy,q=QnOTmR٠$! T91ʣ́SA$BI L#&Gwtđ|4,ƻ6cJ0 JmRm‚+ B"g-// e3e)o a^!LJK1B3D6(O*"SP kL D H!^XU#2,-6Rxb8i3)P݅ҹEU/#+BHM +126c1pD/=Đn$SȶLĴGIg4̐7X.ZuE ol:3Ee )Q ':jy! 7HMQbw@cƎY6,t&t*9q/<^ZȖ fY1t~q8M h'Ii5ϸ&I_|7;8ݼM "ȍ :\k/5MA/; Uz] l*h\([p傝kaiQ{#uDU%$B`MVVJӈ<ɪBTz$B@SccuRi]PЮC;VEbl ƒHPJh JeI 0(.@QSTS.uhX 6 KmѤ֙DL d*K%t+;2A0q`hԨ1¶nf"ml-yںҠPK/5%6.i 1l8ٍ+7^xtUYRS- a`ovnhhMHGϖD;%b(e0:|R$&xNSuDKD, =ZE ")*8@[U$tere%gE聸m.*G~ᩉ+OHƃ.@ЁpӰ ao P![4ȌҒDmdj5I:t5 Z *Ωؑ694HטԮ' X]+sdL$!u&ZeReY;#ѝfE.8!ՊB2dE-5jviV5;(  Nn {~)n;̤$ƋoCa R4Rqkh"Eh8 M6^mQ{+eYV0,%Ρ_҅Wz= 0p~' oD٤b-.Ԭ)O{[zhL9Ut> ^_7p$. X`pL0q$*V܌ZTDފ,L,C*q^JQc$ZT<[DqY$?V](z@&#d) B<֪&SdѮ*t%dYFnUGqUbH(XTY&J 0%(U(\@m5Q,$ H"j@Q, $eUb@PTQ  AV#aoVfh*@0mЯ m2W"(ޔ%@$j-X"!^LVHֲtr,m[ދ$tuTqI u'bZgԥ;D l_t#FHR[I#]c%U;@X-!EZTE@Uub){P1&`$J\*9$Nɭ73<rR M%emeg'aCZZ S.,vzqn9z1Y%FJUEXNs$Gl9D(c$[eIםНsAp<ףS9E%1 iY-uqqkDȵ=!YVHS%+3.l V6]k'A۪ɏqPfVB HhkYUdz]# V"hu`rGThHj,ޘGx!,QVՊ\E6D9U'z\Y\t2 Jh!xwV'o/O -qvWf9&ڋOFcC ;.pP 1ef\Cd mʽ@R:̊4jU!4H v,L&7I ml "t Za}UMigF/4C'bxoJ9S^q .o!i֋2IQ0n[ B29Щ~+Mjhl\H5Y1"zXAL!AĐ3*`B$, Lbn UaxnἊnҮr,2 YjFF;9't&SV46g|Lq@A T 7HhQ*$Jݒ L"f @ 0- RY@n<9҆b0em*a44!xIi{CU`Yfי sr͝*O40\rr' PE Ή39`ssli#1,'iUHl$&H&ʂj&HEO $Q`D0:e&wVm4 :SmSNG5 $ZdO(qT0P̧ʓцAg%t@m4Wr L]^h0 :lpc@FkKD4hV9-8R`(^ CiŎ'z'- &t!fh"w6+0y%TK"!z~I~1 !`-C)$I3xHaD*1 Q,͔:u'PEP8BN0aY RGp^E atp<< !cFU[z ^E19%N+b]RaZ͊X C,/@T9RIW*(.Sk d MnECz@I<@ӮgtȩuF>!*c($O/UMZ@i6VS*` +d,i94+(AW3 f[00iv^ d$ـRlɔ2,0PD(A62>RYywad`NSY$("n[ 9BܧE(H( L+0䷯'AW5 kծ@Uf1Ĩʋ $9*)5 )VBeA)1@  LH@UZ B҄J  L C!(H!=f]o0R-Hɶ,6V\nc{ٹo''19Q-ډ5NgU|!.0ҼʸlU΢+^Gqv.+W#c7V5^?kK7{Ucal'aŅ؁0u^@8rllY"Zc.ŽD[eyՊH\l^!+O';\a^Mpw'͸`ݻ/xDpCO <7b+D Iz1I;EN&2t٪2' +zndD! ^yRgK$C.@d<HVa޽ɉ@T7 +lAl@TC[Zuch` )phIש^єNᰘKh1,4.pEau,y͸@(!ME2YE\Xg&P-3a\ GzU8/ IX/x9Hl4+Fn&`C&O&&2[=jP@p .!9B%| ӊbV\S"=]kM$ yWִ&MP4B WGdE.(!Ta&ZRZ0p `h QLT [ %0Q*2DBL(*ܠB#db& noWT"STR(SkPZhe֮@`}Eʹn@6U.yqvMoSHRwQ3;4r0B=$eT"fh4N)y@tzQIԺA@ ^IΘ>xHO3'Y R)Hwji ˵ !dBl.6Jរ@!(JWYD l897ω`р!,^@1ؘOG s [Ą,8@Ul cͤ>&DT#B!T0gÓB+H$]`uR pFQD C:,gֻ-x,Ib76LțpP 70I5Pt m8#\J8%m@U0caK  d>E(M&yaX";(UDEeA,;  .LLYZ*V5R8$% 5"ܢU9&M3eZvDthA@8+AdDz?F0r+p0ZaV*!7CbDBU8E΅ 1hNkRHJ`UfhQM1 $EL(Rb!4Z׊*$Ui@ 44}UEisB t*:#Z$]baKEh p"D׮ "9ķʰgu@!XӚ+)#YKRk4BMDc@!$P s'DUdVMm \s@3 r gXCo4:x+ZHOl(W'ʶ I1L@% T+DARe4@! NEÆnaL(E.$$&Jl*@%ka"Ⱥ̐88S<:(34ՠO@ Iš"& k `"Ъv~+N"X "LjpZrO-$$KY1'ek؞VeN4,ףEh blhH#Ql#Ucf)`pl͓"JeYiY3- pTFE !ѧUJCzFX%H`4Z!5~F"n) zX "t/v!,]6íj@ +rQSuBRZةVHE*1FHFJx4P|DW*TōX$'EB1A)P 3څ*DH$Ȳ]%PVw5W,L3u u )c6B8wDJhЮY &!W1<$j G ,y"\(m@V9"&ݪ:!18BD z\}E udRTA C+B]ULBi4: "e .&z` HR)E$J9BVSU2"JWQ4 "8b[0AXXEE4(u)-HD0 L&TXjSW Bu kPZBψ٘ QD66"n^Fy }r-+v&T c%̊6q &UWNCT 8Z؏IUƻ债$ pGL7c^akⷬ9m$RQGf+cRׇ S'H$`W7j]s\٣ȩO0  <=F\M`+'M.'8X#˵<09 ËuC^:ё$Hp% 5m` &큢"4:iC9qD*F)7 ʵpIfCN@*&x0"@M NBdx ) P"@)$Q4uiAyApNn EU:@ DM/ 7DNĔ -H=16'ȺJvP._*(l@@B㺦sL7R 3DfRQ&S9*[M)Lk^ ѮȸGKFnNX`L S9(ï%`+u &P j^QH*ltRn@+^ DBXvSvPŔ4d3Rm@)(@l)JkUkT % ]ZD*chmRBL[*0ZY1-EڡO HYe a]O&e% @@Qi$:P>stream Adobed     '$''''$25552;;;;;;;;;;   ####''',,,   ####''',,,   ####''',,,R""   F?!1AQa"Bq$23Rbr #%&'()*456789:CDEFGHIJSTUVWXYZcdefghijstuvwxyzᒓ!1AQaq"BR2Cb #$%&'()*3456789:DEFGHIJSTUVWXYZcdefghijrstuvwxyz?pI.c>*.2T;xHZ糴Hl $q->) p.J!;bZD@PIM 2=iu0u$xJVKI$z5 $%t# K$EI RdVLpm%EELFh&nz ɈjtP(v&f$x Ц3BH$IR!,"ޫ|U'Ċ 1wKlv} Ă5I<%4LQ%RV$h3i*9X`"xa$PEI +M&y E֝s2II!NVwݤI$)@iif)m$RMSV܆c&!P0$.`%P! xf.Ij!'@wjk5@P$^P"`\qЍ %(F 845%D/(4nQzvSAջ"dgDݥS7.:3,D@ڰm2k+9 ni4*KFKL9ej: xưL@Ba`_@L-$4 CN\uW@kp+(2Cyr%n cQIx0r&vPf7JKh inNOqcZa%9 p͋t4]Bm :PvX2_K™5*AqӐsEⳂxkRbl 04ð*f 8)lq&e$00f.OeZeVh֍ƷpK`oQZXlH(S͚ϙhiL=4צjRkZelt -%:ʆ #jVNiTlH ' 1iFVijE ,|+ל,K[-vcX/u$y'{u74ʹiM#s]Tѣ愩4m-UJkfk疊(} nuUfJii:f:i2(jdҪgF(/uO\yUV6Vvs8b>iIEtruyK+o5Q=eݭ>IX hPU]8+6SҜ1ak}3+w]Rڰ8Y0cH />9n:Ӣwҭ/G]5UIN֊2i޼Z9MY4N8Ȁp #AiRκHAR5i\@H QF(bT`@*3XHLhQ4446 -$IIH ƑJPi#QK6G+H Ԓr/coʚ'mh LtA8jN\^ɰ($Еsd-{GY'ncCw.Si.A7LV隕MޙWcAQ&GjhymbEm"f֗),tٴ*hҊ@5D\+Y9bMMXk*LbeVo2Ae m FMcrP4=&EzDip]9MYhJZjkZ*U.Rݎ2=yuZ>"%yi5( (b\nZ7iyVMtWRPBS +i>)FiZYSk$NdB h^#ZbZ̤ 㩹 &=%$@l%\L[")&$FRȶ̻I$k vؒ爠IwT%~NȃkbI$ql6%U4H!` ". R E*#C8 1%vY<s(Zj  t)՚M5) UEIf cmbZ8=%LE"&|n{mtMiw3E|^飍d@:^ਫ਼YDkeyVv6$es-a/+Mn(`J`$ ya)iʪyKVh]X-iLN)JtM.~c3S+UXdY=LK `H-"P;9:t|ףuCbOB[G/37Vj {+=)}ϲ{]tZJOB[XvV'^̙57Viq:L.ܩ~)ΨJ^gUUhT%PxJTUMUpJ[zn(B`pJiv (ȂzaȽI;6F2Ne1+Y-kUmD@MsdkSZ{L‰pSvhDAe6%*`yÂp!0f1N@ }N:tR F s%ȭr:ǜn-l7ǟףŕhexCrz ZNjk':ղZi&㫃{|`ge{ g0tMw}>a ^,>:mCIVݣG^.'QcK 73_6Z:פKyw'a=)j4ӡRQRTa-b  AԈi¡{'FdFi$!s ;9#xh Rkf UUnܠ$I" -|20"f fI%*50RXB 8@]-qt,]ȊHҎ6oj/I92*N!)@ Y \Fa4`-hiTom1nt;QFN!4k Z!/FK ۄe&oBmo@1 d јo6EqA7vEH$̚"҉hjfDLCxS$VRbM“%9o.rMi.P`H&L5݉(H*do-.꣐9o5&Zړ+) $JSvh 6wH+D; 3f+Du3`)\S@h@e4+( BhSc6tU4h`'4MdݡO&OZVn㮴kNvqwgww)njhiWR~vz>fj-736SI:E:::EX=1vl`hkZ pY{' \犆vod-O<@ه 6XrӪyio^zʩoxsǞ/G<Ϡ]6ާ1t&jQ!?&6֍;9Euv~n+ekjbcx7ҰI$SVQ'0q EAD vk =utlHY VIcD7IIT 54 BLjv;|D@#7SNE[c%c$sqҦl>T爤svXG ƫY -I&I BA @q;5DAWp) w%}Q&@@ "Z'h!4"+vlCQ:p4e<ѝI$` ΔisFeD o'fpEPoڹNVmͬ耧` -ҐěJF$M75G&)rk@zq O\t)I0H/4u'|Aww-HE4FM(jnDT H8Hh Hݪ ޣB9P@D7'D  u\Ҍ&LѢjtx!e-K\.#!}hP^U4S KtɠӴ0($QhS]Dd2mۼZ# 1 Wzi*Tԯ=GSEGDE*/$]uiu:ڜ69k&6`3Za \*68, -0 ΍+.т`0!H-+?ҪQWD ѾT8DJ I"˒5ˀU&!@lDeq!ECv )I[\]9'+5r)TiYF爠hsS8(NZ%v"I$J!o;pFPI#G}fk'P j-j*:k]Cy桞_4h*}#׊Mpw7HiiJQWi S(&u"{S9W04e7PA &O 1$f0/ HIԠhJIHDIv3rdDVD`/+L8HN uJ8Eʖ|Z9e7;qJ@ 0wɮpkSkSLqt b]5VoS٘Rte L`p*XI"t'1HR0x^T2+) УsAHF@SC"{$ޚ.&xEp&1r@ 0 yE/N $+h@LNvҥS!r=d&gѪ$IQ \[ӋBBIZ@~̔hIV6Ӷv?ԘdPɳь]>*IThZZi^Di߀$]0sd%u)L5]K`A"D*b%(+J*MYmI$NI:m;HiIT qM sɏDK]IôAq&T+:3V@uBʶOs5[LS~%#ҩCIR7Mɳ4*Gj-iR!8΁ pY1i|]~QWgIb]%kPf4z.vV=Et5lM2ܬsh]~[dvVnuw!Y7JZMƳWpNœxA8 ֠hNq3)i& MUkF:&eZdE-(oЯ)4toss_g@ix0L ;&bTZ$k&b.N/<SJha]TYT*mjZW1.jlz18-15UWMj&N &b;PГ @xJ-!0%38IC:/%4@Bi@ׂ@#FT\yVVL@- *v*K[B`4W52U k\$Qve I+IQU$tEpE Ktԛk,I$I{Jm$aS*("HUW}(]nI)bPŚOH$f3a0+'g; ]JXI%UBIRUnDjѳ "J, iYߐ556&Q$կjUBH p\+O I%4'<R P늖! քˆ:h:Г]jJ q`I4 D4 P|SR6%sVI$7:teM9!Bi) }1$JH6x"M%Mpk EoW%|JoRA[vq*3ܒWܕat!0 ,o(xW JzaRЀ\ $& a3 0 b7A0#\HHAII%* ij! IJMe 39,r h0h [Ј`lJR|s{Ԓ10I$IZr {RM$=ni֭ i7WL WC[kM ޢm"MN*nСH$ uLy^H387RxA9\[(WUJx1# Jrv$.TMĜ3X!Bb0Z*Rw'BT4n$ZJIQ],r1eSV#95BnYK)'VDR:Q$J/ ȵ,XIu*zG3SM<I%[j˄5ʖ\%$I#r@G>%ܵpϤIw-^>:I"t*U->=!ܫZ|zBI$=xK|!$HgO-&|^>$I<C/ơъ I$nbUOrGEu]y $HW 0}I&{agl,BI$lTbI$XduBI$9t>stream Adobed     '$''''$25552;;;;;;;;;;   ####''',,,   ####''',,,   ####''',,,""  ;Q!A1Qaq"B #$%&'()*23456789:CDEFGHIJRSTUVWXYZbcdefghijrstuvwxyz!1"A2QaqRb #$%&'()*3456789:BCDEFGHIJSTUVWXYZcdefghijrstuvwxyz?@ s`"""`!DDDD0 ( *ۍ6Ӱc%~@4$\ IH"׍#E#H @C0dN낋K0b`>'V{$mAcY1cESx\-v\]:8*il%/"r2q A'DRSJzJ2jU5KkhsUkDemMƧpQNQaw0 e;7 ,u34:d!sWSҥWL=Y]M3E8 i t.Z+%e`!A!DDQt'3 3(M!(pdZ4-&(ǕNS B-j5YDyGC*M-`u֑:Nun6W" a# E\NV2X5u4#6dɨlj/3乥 t@3TDD@3 (""""""1DDH ""& 2DDD .HLJ""(5VZU 2Ie{i4pV[W-v+xG|0LsUR(Ҩ*@&3sQV@eqk:ѰpXf0r;pk$p# /^Fg1{ysw}R}gds d. "8<^\!v"*P- #BN.B"b2DDD 2FࢭZt"װyGlU Kگ t&d2Y%z2pH=v+W$VA!!%a00YDD@DD@DD@DD DDD$!`""p&$[ 6A6 (uEUq<(Rܳt:їޛ,T^ qf9Bl)\X""`!DDDD@0HDDDA&Q1HDDDr 5tDO@it~V.2 itwlwvGɡP r޽p݇ڍj4/^!biHb p7ts-cqJ\=U+n2.*x59Xpv-uaUbb־u;x"w7=Ăȴ;6;0yuzW:\9W*iUefO8b)(uVG|W0LGկ\tDLCDDDDDD*D9*VӠ٨UWKrօMUT7yJc_# (aST4SLhJ""ĆjDD C \]rTjx́Z*ps빠CCݕt:Lul]*ZQk ^D[ҧ<6`O@uq:tiw>\ 80LC`OPDDD,"" ae DE4IhXDDUסvByIUJyL#7AvlB""$eTN$Es``) 0B""&8#!&JA! ""&"D7XDLv*bUTyHb9<:GkguZ9gTp1MTQn\2 JtJT X4nyIrw/)(A/i@ |̒y5PDDD֒M؞z-36_-l&inND__MQ0ӕcf7\nsgbLi6as-$ -UuzQqDɀ, D@A:iĬ""*؆e!9 """LLb2]˷fO؊j]Rx/,V"" pU49 Q]2vl\X""iCӶ˶=Tӭ&u*p3E[Q;`mp.-;Iӽ17SHHXE ŔLдXDEd1##!"0HDDD@9 DDDD9-$\gu56|S!#̏)Z*kjn9&R",얜ZT>1wzfui*nvlF` ,,~Օz)"mF10F0m9vHLud_u֬%?niɐ-'mE9DgQJ\#GYR^@Cu:]vor7N%""1""&1 ""@$X|~"n< MhnY.I:Jpf(.yȶ݊/ue"YN.jת*[]7.փ(iSoMhjnKޤtQ/~i˸fF;0`'qvqx]cfs5_>KU#@# jJW4RM6ID -pVـQD "" C,Ѽ)~3FܧO NA;UpbE6%f‡3mɅVBɶqeK*fl$n((5VPj.stlC>׺ DYXN.ZVle$Vj6"P &:V^iTn/N'N6apIm$D"""""E5V*w7jDDT ގ)Shk)jRI+MR"4tu$QlDDEe,u7'&"""&"ѐ#L@e""$!XDDLC4o.\8JhtᎼ:^1~@xk+ܲfM΋ˋX5i$XAEcK7WU-¾QxF^Z8ϳy'y MS|vh'M TZJ(ޚ(ɥSZ^ҼUUgUFkRr[JB]4l]zWf+6*R{VBtoH]z<mW~h+lڞ:k2(ۺ[m=7 xʕ\ԁĨY٢܃wvAgj+NOK=EYlӧ3SwY&쯋Ӵ`UV5Rh$?-ɸւ!aLe$rgA,#p69-x㫴a dV4X9k{P=;dZ^lN2{OSU*MYbm#\U戊i k/^'hD,""&@25QFRҜ\5'DDEXFS'^JudЈ2-U-GYDDI=5v-(""P'MDDP1]TDBDjI96TU5[BXزztkWB8ҪeYDD[IoETFRγ5u2.uXZJ aa4ȄDDVH6BFbDDE$2)3 (b$& DE!@QlFVk 9M~d5SrUõ -=n0[4n)DjZw,@U,"k͚'+Gy.^V%򪭾LƂk~9^:o pe~N163Y" C9A7 S=G{Y2 nˮF+># W~I䖚u2 gAksI+zZ֌e(rSRQ˽U+BA*:ڙ&750t)dVeglt@C->&*F.S%dU#CX$9 hX(+؊4)I]o4(\l$.ˢDDE7œZ܄fӘDDRVSNU5z FMDDEeSn'IM/5`W'K]Yc=Z Q#R """""""Xn,)nP6YDDNn+8\Adϭ$80uNu2(ĘDDEEܘmDDEUT&(.jyNŅݤ", pJ՚EZ69=̬:|Z ;m9zIٰӓ*& ӥi.(qh ͽazY,:Ј[UIɛ:zuȶ!aZdDDD5Pp`AUaM"""H1# """"CA$&#V)ߛ&oܧFyV"" )j2ڛ I-"u(|R VP饻qM9cIk;j bQ"yc;76J!]PTeaKjVa]۾Ԝ6JR!za=#Z]5yBE,C)iQl`؊q=JB!vj< aF7MdkM1:8;9щ'Y:sToEIP-gUc[VZYPM'&sv \v tpi,a0D Vk5Tk-tj$Ѧ3Tbk9j$k.E0rbLɷh:W¿,nLH0ƈS;}1\舘 D݄"""nȺ3hNHIQ.tŧIx( Ta70e1 ="",*MRl͛ ;][[ΟM]JVjՈiADDV'4 >1:t" ""`a, R""LpA Ҷ ql s @ItD[Ӧ cKtS])V+t[-[O&ÉkKݭ)Z$څfb)'$9Ŭw귩MXZĴ$MoeH<ԒZ<D$sZĨʪRY:tqBsn8sU)'͕W,e7,!y"²n TiiY6DDRUmJTOC,eDDET9)Umj""+A44B""& l""ir"""V5s{GFV~UU/)No،TvlQahb4mM.\nuѥ(P{Zs2LV(TmG* ;]G 2#d[p$t۪|~-tZx.xv i;-%vq,v,K蹗PHXEU:О´%.qr""!msq Fpm4 KNvӨoKzw*R]UJydudmL5mFh՚(7 H @8""%M\^k*5 k`DDEpQ""LZ 2,"""z2Y+=U::jt9g3?QsJ{a$ΣC1t𘦺ZX$tp;zw"Q#jn$"FS0ԇXā'E}S^drQJo0)rokUEtZt\h u\'%:%Lu<qyOsI]ҧR85f3u׻(3, 1=COPpaQH`6ܳmNUa2m̖;0%BxM5M{ϗ']T+aȻ9VCzX@Ss^e)f3x_> ?`X{=zԃR[]\Bzw|Ҳ7UqVSfQ'opgC񙋸dž=Qdsh&Qu-e aP{XZ9$<![1M4v=EӯLU^É1S1ni &, 3a.۷54il*ή n4a͈GO?fSK  _gUJP1j ]-`k.&贑 WUIҝ/q0o(jBe"E=${TJԄX[Xܪ$NNU9S+MIXFs zG#XDDE) 㕷=Umq^RS#l\o)6?b1PCve"UMㆂ-$(,Pޕs`L$ֆ }XfQ=!Bwz+""+7NRQ=Yzn@;^JEq^VEP֔pGO o]YĶxn22yTV 8N9a+xlž\I7/Ja9W^-vU*K`4 vj`*f)5X֟jX׆ͯBSµ[HHgX!p| ܭHQ<_ѐ4@04qZM =єNqS,M9"4oE6""CjKZ&A LKOPZ22@kڧ7 Iސ>rɝO71@{Y]ik(K Z@l HSUiZƪ+ڃz.C8A yuE2& LLn6ys>ySۻ 7MԁLvCD&bR:U֎F#qlv$X랫DKO+X͖ tO6 '\s:th )ZB""!Tww"O.؃h&QU x\8_ <MYDYAJ5]C"b)r Boe0iيFeriە"WB I9NJ#`mKlOd7biS`Qc=@&ْD;,: 7jjpVFbQ`oX0{/^Giv<`ͣJqN,j `gTZDLzVm9])f`sf5H[+ZXG@$ 6̰נ5㩧 kI0rLut n5ĝLFq uHqud &A=oE7GB1  CdC1QLۋ+#Ѩ{su"$4wDat5&^a;Vhp 8v>Y#=q-Y#ZΖõEC&[W1#^]D/i {3躞AR% :8(Vq`wQbJ=VN-AD w;bmMqb5Y(;@DDD"G7r;aIDYCn*wմBMJ/]͂ !advKz]I8iZ w` Q2au4f XΓe$X߶X1#,'x #zi1Մl`Ç,@c?n5; 3#|si ΋-%|Zlň:Db-0+ SEUK;Iu@ gk,c:vQZWT*=S.NoM.*୔Ṣ͆֐jiI&"G2BҤni_zMlwwuxzۼYZ[ۥS5EQS2d,ږhg8''7ʺSc&nS-ӒmE59ihnfvc!XZJ,m ts;IlrU,Sנ[YJUTD+e"݊"*ӽ4YE-٤9te\:t-jA܈IU5ii\YfS;Y'CJ"""v nds=!ԫiۤgv|'Z<`Ьl$"""Ѧ؍NnY5RM*nWRΆDҳsu1:jg KHn +`6ҷnZ  L@Nr.eEbg !LP38[AFGh53FѿcڕΦMpgP :)n΍2 )bctP/̋ƞSyp ٳ`N6q{(4rjOM}H.i(LpBpsz"R'ku=-EK5U&^6T9:s`)pX1As.fo3M:Nk !e˷ C)kJ3xtiúMhEYY(MiѣG P-:6*fYadO,%Ž6\rԨ;YYd_fvV۠p+9(D0C,dNYF6asnݒbs~@NWA:@ͅAwnne @IH"܋mĎ'Ky/=[ΚH5UK\Xnދv$ӧ[DOQdmHRn-[96HE=nkftXp X-:@ kͻNaZUU g bQj/MO@RLܫU-ilMqMPVVnm^$1 H+-VRZKϼS۴O,ҘWv5 +E)]N$T6Ѭɿ&8߸R",¹+3CQMO}M=7:EՔFZ,,Ĭ-SU&Z[KvVC<0yIM#hHXErJ0+5`8@ܙYn^"sMbGbt=5%9]acN$D @ z0Av[ͿѤ͉â~-zәB.X \36ǶQ&#eO\vf7`Ӧf7I6l9rmR*D27=$d0<ʙł)֥ր#(u4$:IQe&-i׻:fB^1h /sBx6eѨ7QXMFΛLhbZ5\jf)! ͗HlLe:s;$˩83! $^\ d74K;\V:^ƗAHbHQyO a3e> o'ޫI{H2c@,ٹj6@2S>EH p5K)s<-bip Gŋkzm ;) ݚ2lab2ZFE)&81Ե*a}:*Վ NF*VW)J+WaLGU--J,:UEUM4KQ&u,xDfT."f5XNFJ]oPТnn%:Z:V=UxJjP[fcУHqyfqa%a#t,ͺS)bEFXwhz"$\y76KVM]#.4 01+( A:g9lZ7^2uw" fB-NuLr"U8fw^io z(ݸHMΰ׫[LB0$sI 5j@"r.8S 0er92 3q]ȋtRM.}&zX,s@#Ȥԫ3*"'EݕS6 Q@=Z8Þ?z[`ԔFӅ҉ մ  dMcR<^`۳c{GSi I0b= zblIf50AQ4լْsh1}^{]UsFNE"圕^bF#M Z7i&`Emsi#0-Ϋd\ӔAG[BhZ2Ls`[dqfP3XTs"g6h;Zaq7p,rS5&QGem2L}79Rh;6t3B.1@ sX+zm-1MfBz s$ ie#R&֋) #N޽0 Ĉ3tVn˚ZfGIRT 0 ^b\d0)Tv'5Zq1OTWsZѣ[5-p*E:Y_s"` \!nXu&wOBAoϻFDK8;p,htʫwAPMQyyȍ󩕶B hg-:3Υ^I h53K_I$HeSs 5G$]ʱ*sT͞7wVaykmq+э!ILm3@ |_2ݙFlՓ٪;E<(Q$WZnx6^B$X ^a{l2ȹΰ;uAn졾Jփ+nӛYFRN筼t z,: al'I/R5\ X!AUM1e 1$8zQvP*$ubEX͉hĴgn>EJtwT^EJtwTIN%ꢵ*/UUP`y&݊Mɻ C2QkOǴ+ڗ Ɵ-ݏhW.AI` wEC=U- WmK`4hJ/G[CK}Rr{5`ʯ"{UWSٽwRBHЪj5E;l;X0ڢ՜uJ헓9L9=U#(ûnVY^ͼuWHI"X =S{1=h^Mh{t(ObN۬j|oOĠJ ب#ObH+z\=F \=FDunDzxOW }RF<1F<1mayS(J'@bxWjQe[-Y=U݂O E;ZM_`=RW5=EyC%{3SB@jt++g($3ڔ^צy^`4,+,݇nOUa;i= k"v[HrrGPVrSA{g(u;d7B, V)quw[RM 'JmFֆ%ƴ3CݖVꕸ仨VhQ, a/M݈^cS^#zHރS-i-ΝҞ!K,8fzw/UznrՒSf?hy.6o3,啲a\>za:]>֯L'VH endstream endobj 1620 0 obj <>stream endstream endobj 1619 0 obj <>stream endstream endobj 1618 0 obj <>stream endstream endobj 1603 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(IC)31(G-\013\001\202\220\025\202\002\013\225\220\205 \r\022\025\227\016\001\n\016\ \n\013\017\016\006)-10(\026\r\013 \225\025\002\024\220\002\025\r\013\001\220\205 )]TJ 0 -1 TD [(\221\025\007\001\025\006)-9.9(\007\025\203\001\025\202)10(\025 \221\002\205\024\025\n\220\016\017\001\025\202)10(\025 \007\025\006\n\215)-19.9(\026)11(\013 \221\002\220\022\025\221\016\002\013\026\220\r\001\025\024 )]TJ T* [(\007\016\017\016\001\220\220 \006)-10(\007\025\217\001\020\207 \221\002\205\024\025\n\220\016\017\001\020\207\ \006\r\220\224\016\203)]TJ 31.181 2 Td [(IC)31(G-angiogr)21.1(aph)31(y for r)31(ectal adv)10(ancement flap in patients with anal f)-21(istulas)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0.501 Tw 10 0 0 10 42.5197 724.8299 Tm (\017\027\021\030\026\024\023\036\030\026\006\017\024\027\027\024\005 ICG\ -\026\027\020\017\024\020\030\026\235\017\017 \007\035\016 \024\006\036\027\ \022\017 )Tj 0.636 Tw 0 -1.218 TD (\022\030\024\r\024\f\027\026\002\032\036\027\017\016 \023\024\035\027\024\ \f\035\024\005\027\024\020\024 \035\024\f\022\031\021\026 \023\030\016\n\ \024\005 )Tj 0.11 Tw T* (\022\017\001\022\017 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\035\036\004\036\027\017\017 \f\035\024\032\027\t\b \f\r\017\013\036\005\ \r)Tj /Span<>> BDC ( )Tj EMC (\n\017\030\024\r\024\005 \035\017)Tj 0 Tw (-)Tj 0.064 Tw T* [(\021\036\030\026\021\031\030\036 )0.5(\036\007\017\027\017\004\027\t. \200)]TJ /Span<>> BDC ( )Tj EMC 9.444 0 Td [(\004\026\f\021\027\024\f\021\017, )0.5(\023\024)]TJ /Span<>> BDC ( )Tj EMC [(\007\026\027\027\t\n )0.5(P)19.9(ubMed, )]TJ 0.088 Tw -9.444 -1.218 Td [(\024\023\031\002\035\017\022\024\r\026\027\026 \035\017\001\034 1 \f\021\ \026\021\034\016 \(P)35(r)-37(imo-R)11(oma)-17(guer)-32.9(a V. e)-12(t )]TJ 0.216 Tw T* (al, 2023\), \r)Tj /Span<>> BDC ( )Tj EMC (\022\024\021\024\030\024\005 \024\023\017\f\026\027 \036\007\017\027\017\ \004\027\t\005 \f\035\031\004\026\005 \017\f)Tj 0 Tw (-)Tj 0.177 Tw 0 -1.218 TD (\023\024\035\034\024\r\026\027\017\016 ICG-\026\027\020\017\024\020\030\ \026\235\017\017 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\023\035\026\f\021\017\022\036 \023\024\035\027\024)Tj 0 Tw (-)Tj 0 -1.218 TD (\f\035\024\005\027\t\n \035\024\f\022\031\021\024\n [15].)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 42.5896 603.0498 Tm (\017\034\r\241)Tj 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0 Tc -0.065 Tw 10 0 0 10 42.5197 578.6938 Tm [(\200 \f\024\r\024\022\031\023\027\024\f\021\017, )0.5(\220\021\024 \017)]TJ /Span<>> BDC ( )Tj EMC 8.907 0 Td [(\024\002\031\f\035\024\r\017\035\024 )0.5(\026\022\021\031\026\035\034\027\024\f\021\034 )0.5(\027\026\f\021\024)]TJ 0 Tw (-)Tj 0.008 Tw -8.907 -1.218 Td (\016\013\036\020\024 \017\f\f\035\036\007\024\r\026\027\017\016, \006\036\ \035\034\033 \022\024\021\024\030\024\020\024 \016\r\017\035\026\f\034 \024\ \006\036\027\022\026 )Tj 0.341 Tw T* (\006\036\035\036\f\024\024\002\030\026\027\024\f\021\017 \017\f\023\024\ \035\034\024\r\026\027\017\016 ICG-\026\027\020\017\024\020\030\026\235\ \017\017 )Tj 0.019 Tw 0 -1.218 TD (\007\035\016 \235\024\030\n\017\030\024\r\026\027\017\016 \023\024\035\027\ \024\f\035\024\005\027\024\020\024 \035\024\f\022\031\021\026 \023\030\017\ )Tj /Span<>> BDC ( )Tj EMC (\035\036\004\036)Tj 0 Tw (-)Tj 0 -1.218 TD (\027\017\017 \f\035\024\032\027\t\b \023\030\016\n\024\022\017\001\036\004\ \027\t\b \f\r\017\013\036\005.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.01 Tc 0.018 Tw 14 0 0 14 42.5896 493.4478 Tm [(\f\026\017\031\034\022\024\232)5( \031)5(\016)-18.3(\240\034)-31(\024)35(\037\226\232)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0 Tc 0.097 Tw 10 0 0 10 42.5197 469.0918 Tm [(\207\t\035\024 \r\t\023\024\035\027\036\027\024 \023\030\024\f\023\036\022\ \021\017\r\027\024\036 )0.5(\022\024\020\024\030\021\027\024\036 \017\f\f\035\036\007\024)]TJ 0 Tw (-)Tj 0.116 Tw 0 -1.218 TD (\r\026\027\017\036, \024\f\027\024\r\026\027\027\024\036 \027\026)Tj /Span<>> BDC ( )Tj EMC (\017\031\004\036\027\017\017 \017\027\021\030\026\024\023\036\030\026\006\ \017\024\027\027\024\005 )Tj 0.327 Tw T* [(ICG-\026\027\020\017\024\020\030\026\235\017\017 )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC 8.766 0 Td [(\036\036 )0.5(\r\017\007\036\024\026\023\017\f\036\005 )0.6(\023\030\017)]TJ /Span<>> BDC ( )Tj EMC 9.918 0 Td (\035\036\004\036\027\017\017 )Tj 0.47 Tw -18.684 -1.218 Td (\f\035\024\032\027\t\b \023\030\016\n\024\022\017\001\036\004\027\t\b \f\ \r\017\013\036\005 \f)Tj /Span<>> BDC ( )Tj EMC (\027\017\r\036\007\036\027\017\036\n )Tj 0.067 Tw T* (\023\024\035\027\024\f\035\024\005\027\024\020\024 \035\024\f\022\031\021\ \026 \023\030\016\n\024\005 \022\017\001\022\017. \200)Tj /Span<>> BDC ( )Tj EMC (\017\f\f\035\036\007\024\r\026)Tj 0 Tw (-)Tj 0.145 Tw T* (\027\017\036 \002\t\035\017 \r\022\035\033\004\036\027\t 9 \023\026\006\017\ \036\027\021\024\r. \222)Tj /Span<>> BDC ( )Tj EMC (\027\017\b 6)Tj /Span<>> BDC ( )Tj EMC (\(66,7%\) )Tj -0.002 Tw T* (\n\031\032\004\017\027 \017)Tj /Span<>> BDC ( )Tj EMC (3)Tj /Span<>> BDC ( )Tj EMC (\(33,3%\) \032\036\027\013\017\027\t. \200\024\030\026\f\021 \023\026\006\ \017\036\027\021\024\r \f\024)Tj 0 Tw (-)Tj T* (\f\021\026\r\017\035 \024\021 21 \007\024)Tj /Span<>> BDC ( )Tj EMC (69 \035\036\021.)Tj 0.138 Tw T* (\222\f\f\035\036\007\024\r\026\027\017\036 \002\t\035\024 \024\007\024\002\ \030\036\027\024 \035\024\022\026\035\034\027\t\n \027\036\026\r\017\f\017\ )Tj 0 Tw (-)Tj 0.128 Tw T* (\n\t\n \220\021\017\004\036\f\022\017\n \022\024\n\017\021\036\021\024\n\ , \r\f\036 \023\026\006\017\036\027\021\t \023\024\007\023\017\f\026\035\ \017 )Tj 0.262 Tw T* (\f\024\020\035\026\f\017\036 \027\026)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\r\036\007\036\027\017\036 \024\023\036\030\026\006\017\017 \ \r)Tj /Span<>> BDC ( )Tj EMC (\031\f\035\024\r\017\016\b \017\027)Tj 0 Tw (-)Tj 0.477 Tw T* [(\021\030\026\024\023\036\030\026\006\017\024\027\027\024\005 )0.6(\026\027\020\017\024\020\030\026\235\017\017 )0.6(\f)]TJ /Span<>> BDC ( )Tj EMC 15.308 0 Td (\017\f\023\024\035\034\024\r\026\027\017\036\n )Tj 0.228 Tw -15.308 -1.218 Td [(\r\027\031\021\030\017\r\036\027\027\024\020\024 )0.5(\235\035\031\024\030\036\f\006\036\027\021\027\024\020\024 \022\030\026\f\ \017\021\036\035\016)]TJ /Span<>> BDC ( )Tj EMC (\227 \222\037\003 )Tj 0 Tw T* (\(ICG-\026\027\020\017\024\020\030\026\235\017\017\).)Tj 0.559 Tw T* [(\025\030\017\021\036\030\017\016\n\017 )0.5(\r\022\035\033\004\036\027\017\016 \023\026\006\017\036\027\021\024\r )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC (\017\f\f\035\036\007\024\r\026)Tj 0 Tw (-)Tj 0.207 Tw T* (\027\017\036 \016\r\017\035\017\f\034: \027\026\035\017\004\017\036 \021\ \030\026\027\f- \017)Tj /Span<>> BDC ( )Tj EMC (\220\022\f\021\030\026\f\235\017\027\022\021\036\030\027\t\b )Tj 0.169 Tw T* (\f\r\017\013\036\005 \023\030\016\n\024\005 \022\017\001\022\017 \030\026\ \035\017\004\027\024\005 \f\035\024\032\027\024\f\021\017, \022\030\017\ \023)Tj 0 Tw (-)Tj 0.318 Tw T* (\021\024\020\035\026\027\007\031\035\016\030\027\024\020\024 \023\030\024\ \017\f\b\024\032\007\036\027\017\016, \030\026\027\036\036 \027\036 \024\ \023\036\030\017)Tj 0 Tw (-)Tj 0.025 Tw T* (\030\024\r\026\027\027\t\036, \f\024\020\035\026\f\017\036 \023\026\006\017\ \036\027\021\024\r \027\026)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\r\036\007\036\027\017\036 \017\027\021\030\026)Tj 0 Tw (-)Tj T* (\024\023\036\030\026\006\017\024\027\027\024\005 ICG-\026\027\020\017\024\ \020\030\026\235\017\017.)Tj 0.51 Tw T* (\025\030\017\021\036\030\017\017 \017\f\022\035\033\004\036\027\017\016:\ \023\024\f\021\035\031\004\036\r\t\036, \r\030\024\032\007\036\027\027\t\ \036 )Tj 0.119 Tw T* (\f\r\017\013\017, \f\r\017\013\017 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\024\023\031\b\024\035\036\r\t\b \026\002\024\035\036\r\026\027\017\016\ \b, \f\r\017\013\017 )Tj 0.583 Tw T* [(\021\031\002\036\030\022\031\035\036\027\024\005 )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC 8.253 0 Td [(\026\022\021\017\027\024\n\017\022\024\021\017\004\036\f\022\024\005 )0.6(\220\021\017\024\035\024\020\017\017, )]TJ -0.019 Tw -8.253 -1.218 Td (\f\r\017\013\017 \r)Tj /Span<>> BDC ( )Tj EMC (\r\017\007\036 \023\036\030\017\026\027\026\035\034\027\t\b \023\030\024\ \016\r\035\036\027\017\005 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\036\027\017 )Tj 0.008 Tw T* (\025\030\024\027\026 \017)Tj /Span<>> BDC ( )Tj EMC (\016\r\036\027\027\024\020\024 \022\024\035\017\021\026, \026)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\032\036 \024\023\036\030\026\021\017\r\027\t\036 \r\n\036)Tj 0 Tw (-)Tj T* (\001\026\021\036\035\034\f\021\r\026 \027\026)Tj /Span<>> BDC ( )Tj EMC (\021\024\035\f\021\024\005 \022\017\001\022\036 \r)Tj /Span<>> BDC ( )Tj EMC (\026\027\026\n\027\036\036.)Tj 1.589 Tw T* [(\210\002\013\017\005 )0.6(\007\017\026\005\027 )0.5(\017\f\f\035\036\007\024\r\026\027\017\016 )0.6(\023\030\036\007\f\021\026\r\035\036\027 )]TJ 0 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC (\030\017\f\031\027\022\036)Tj /Span<>> BDC ( )Tj EMC (1.)Tj 0.042 Tw T* (\200 \007\024\024\023\036\030\026\006\017\024\027\027\024\n \023\036\030\ \017\024\007\036 \r\f\036 \002\024\035\034\027\t\036 \023\030\024\001\035\ \017 \024\002)Tj 0 Tw (-)Tj 0.045 Tw T* [(\f\035\036\007\024\r\026\027\017\036 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC [(\f\024\024\021\r\036\021\f\021\r\017\017 )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC 12.293 0 Td [(\203\026\006\017\024\027\026\035\034\027\t\n\017 )0.6(\022\035\017\027\017)]TJ 0 Tw (-)Tj -0.052 Tw -12.293 -1.218 Td (\004\036\f\022\017\n\017 \030\036\022\024\n\036\027\007\026\006\017\016\n\ \017 \023\024)Tj /Span<>> BDC ( )Tj EMC (\035\036\004\036\027\017\033 \f\r\017\013\036\005 \023\030\016\n\024\005\ )Tj 0.043 Tw T* [(\022\017\001\022\017 [16], )0.5(\r\022\035\033\004\026\033\013\036\036 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC [(\f\036\002\016 \022\035\017\027\017\004\036\f\022\017\005 )0.6(\024\f\n\024\021\030 )]TJ 0.392 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\024\023\030\024\f, \f\021\026\027\007\026\030\021\027\031\033 \035\026\002\ \024\030\026\021\024\030\027\031\033 \007\017\026\020\027\024\f\021\017\022\ \031, )Tj 0.245 Tw 23.244 64.543 Td (\026)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\032\036 \026\027\024\f\022\024\023\017\033, \r\017\007\036\024\ \022\024\035\024\027\024\f\022\024\023\017\033, \211\003\222, \204\217\230\ )Tj 0 Tw 0 -1.218 TD (\n\026\035\024\020\024 \021\026\026, \235\017\f\021\031\035\024\020\030\ \026\235\017\033.)Tj -0.017 Tw 0 -1.218 TD [(\200\f\036 )0.5(\024\023\036\030\026\006\017\017 )0.6(\r\t\023\024\035\027\016\035\017\f\034 )0.6(\f)]TJ /Span<>> BDC ( )Tj EMC 12.145 0 Td [(\023\024\n\024\013\034\033 )0.6(\024\002\024\030\031\007\024\r\026\027\017\016 )]TJ 0.145 Tw -12.145 -1.218 Td [(K)-16(ar)-30(l S)15(t)17(or)-23.9(z IMA)16(GE1 S\250 H3-LINK \(T)35(C 300\))]TJ /Span<>> BDC ( )Tj EMC (+)Tj /Span<>> BDC ( )Tj EMC [(C)13(ONNECT\250 )]TJ 0.393 Tw 0 -1.218 TD [(\(T)35(C )0.5(200\) )0.5(\(\206\036\030\n\026\027\017\016\) )0.5(\023\024\007 )0.6(\024\002\013\017\n )0.5(\024\002\036\002\024\035\017\r\026\027\017\036\n )]TJ 0.045 Tw 0 -1.218 TD (\r)Tj /Span<>> BDC ( )Tj EMC (\023\024\035\024\032\036\027\017\017 \023\026\006\017\036\027\021\026 \007\ \035\016 \035\017\021\024\021\024\n\017\017, \f)Tj /Span<>> BDC ( )Tj EMC (\017\f\023\024\035\034\024\r\026)Tj 0 Tw (-)Tj -0.034 Tw 0 -1.218 TD (\027\017\036\n \f\021\026\027\007\026\030\021\027\024\020\024 \027\026\002\ \024\030\026 \b\017\030\031\030\020\017\004\036\f\022\017\b \017\027\f\021\ \030\031\n\036\027)Tj 0 Tw (-)Tj 0.197 Tw 0 -1.218 TD (\021\024\r, \023\030\017\n\036\027\016\036\n\t\b \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\r\t\023\024\035\027\036\027\017\017 \023\030\024\n\036\032\027\024\f\021\ \027\t\b )Tj 0.19 Tw T* (\024\023\036\030\026\006\017\005. \212\035\016 \023\030\024\022\030\026\001\ \017\r\026\027\017\016 \f\r\017\013\036\r\024\020\024 \b\024\007\026 \017\ \f)Tj 0 Tw (-)Tj 0.14 Tw T* [(\023\024\035\034\024\r\026\035\f\016 )0.5(\030\026\f\021\r\024\030 \n\036\021\017\035\036\027\024\r\024\020\024 \f\ \017\027\036\020\024, \022\024\021\024\030\t\005 )]TJ 0.077 Tw T* (\027\036\023\024\f\030\036\007\f\021\r\036\027\027\024 \023\036\030\036\007\ \r\r\036\007\036\027\017\036\n \030\026\r\024\007\017\035\f\016 \r)Tj /Span<>> BDC ( )Tj EMC (\f\024)Tj 0 Tw (-)Tj T* (\024\021\027\024\001\036\027\017\017 1:1 \f)Tj /Span<>> BDC ( )Tj EMC (3% \030\026\f\021\r\024\030\024\n \023\036\030\036\022\017\f\017 \r\024\007\ \024\030\024\007\026.)Tj 0.102 Tw T* [(\215\036\030\r\t\n )0.5(\220\021\026\023\024\n )0.6(\023\024\f\035\036 )0.5(\031\f\021\026\027\024\r\022\017 )0.5(\022\035\033\r\024\r\017\007\027\024\020\024 )0.6(\026\027\024)]TJ 0 Tw (-)Tj -0.03 Tw T* (\f\022\024\023\026 \007\017\026\n\036\021\030\024\n 23 \n\n \f)Tj /Span<>> BDC ( )Tj EMC (\023\024\023\036\030\036\004\027\t\n \r\t\030\036\024\n \027\026)Tj /Span<>> BDC ( )Tj EMC (1/2 )Tj 0.064 Tw T* [(\024\022\030\031\032\027\024\f\021\017 )0.6(\023\030\024\r\024\007\017\035\024\f\034 )0.5(\023\030\024\022\030\026\001\017\r\026\027\017\036 )0.6(\f\r\017\013\036\r\024\020\024 )]TJ 0.087 Tw T* (\b\024\007\026 \f)Tj /Span<>> BDC ( )Tj EMC (\024\023\030\036\007\036\035\036\027\017\036\n \r\027\031\021\030\036\027\ \027\036\020\024 \f\r\017\013\036\r\024\020\024 \024\021\r\036\030)Tj 0 Tw (-)Tj 0.235 Tw T* (\f\021\017\016, \026\021\036\n \r)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\017\235\036\030\017\004\036\f\022\031\033 \r\036\027\031 \r\ \r\024\007\017\035\f\016 \222\037\003 )Tj 0.08 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\007\024\036 0,25 \n\020/\022\020 \f)Tj /Span<>> BDC ( )Tj EMC (\006\036\035\034\033 \017\031\004\036\027\017\016 \026\027\020\017\024\026\ \030\b\017\021\036\022\021\024)Tj 0 Tw (-)Tj 0.075 Tw T* (\027\017\022\017 \023\030\016\n\024\005 \022\017\001\022\017 \017)Tj /Span<>> BDC ( )Tj EMC (\r\t\002\024\030\026 \020\030\026\027\017\006 \235\024\030\n\017\030\031\ \036\n\024\020\024 )Tj -0.043 Tw T* [(\035\024\f\022\031\021\026. \215\024\f\035\036 )0.5(\r\r\036\007\036\027\017\016 )0.5(\222\037\003 \r)]TJ /Span<>> BDC ( )Tj EMC [(\023\036\030\017\235\036\030\017\004\036\f\022\031\033 )0.5(\r\036\027\031 )]TJ 0.257 Tw T* (\023\036\030\r\024\024\004\036\030\036\007\027\024 \027\026\f\021\031\023\ \026\036\021 \026\030\021\036\030\017\026\035\034\027\026\016 \235\026\026\ , \026)Tj /Span<>> BDC ( )Tj EMC (\036\036 )Tj ET q 274.961 100.996 221.102 364.61 re W n q /GS0 gs 221.1023475 0 0 364.6628396 274.9606228 100.9433604 cm /Im0 Do Q Q BT 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0 Tw 9 0 0 9 274.9606 90.1959 Tm (\022\t\217\210\b\002\220 1.)Tj 0 0 0 1 k /GS1 gs /T1_4 1 Tf ( \200\025\016\026\017\021 \025\t\t\023\031\030\n\027\026\021\025\002)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0 -1.2 TD [(F)-16(igure 1)47.1(.)]TJ 0 0 0 1 k /GS1 gs /T1_4 1 Tf [( S)28(tudy design)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\033\030\031\030\213\b)-20.9(\035\231\213\233\t \021\032)50(\b)42(\032\231\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj /T1_5 1 Tf 25 0 0 25 512.8268 56.0378 Tm (93)Tj ET endstream endobj 1604 0 obj <>stream Adobed     '$''''$25552;;;;;;;;;;   %%#(((((#,0000,7;;;7;;;;;;;;;;   %%#(((((#,0000,7;;;7;;;;;;;;;;   %%#(((((#,0000,7;;;7;;;;;;;;;;""    u5tS2TUq!16QsA$Babr "#%&'()*34789:CDEFGHIJRVWXYZcdefghijuvwxyz d!1AQq"2a3Rr#bBS $%&'()*456789:CDEFGHIJTUVWXYZcdefghijstuvwxyz?@0DE:m-^w!?$ycns0>[Tc?K })̗x+Cw޻B~}*p;r`vp>[ѽae2]s%4{aH~}*p;r`vp>[ѽae2]s%4{aH~}*p;r`vp>[ѽae2]s%4{aH~}*p;r`vp>[ѽae2]s%4{aH~}*p;r`vp>[ѽae2]s%4{aH~}*p;r`vp>[ѽae2]s%4{aH~}*p;r`vp>[ѽae2]s%4{aH~}*p;r`vp>[ѽae2]s%4{aH~}*p;r`vp>[ѽae2]s%4{aH~}*p;r`vp>[ѽae2]s%4{aH~}*p;r`vp>[ѽae2]s%4{aH~}*p;r`vp>[ѽae2]s%4{aH~}*p;r`vp>[ѽae2]s%4{aH~}*p;r`vp>[ѽae2]s%4{aH~}*p;r`vp>[ѽae2]s%4{aH~}*p;r`vp>[ѽae2]s%4{aH~}*p;r`vp>[ѽae2]s%4{aH~}*p;r`vuG09։$V]| +{#˕Nd9ZKiwАS&nSQ2KFJp>[ѽae2]s%4{aH~}*p;r`vp>[ѽae2]s%4{aH~}*p;r`vp>[ѽae2]s%4{aH~}*p;r`vp>[ѽae2]s%4{aH~}*p;r`vp>[ѽae2]s%4{aH~}*p;r`vp>[ѽae2]s%4{aH~}*p;r`vf`{(s8໠]nѽa*o,e)5617Ywt2])\q]뎱w cy!8nA\ p;r$hU]Q@0DEKl|^z%Kl|^z%ѥL37x^+iU4 3W]+Ac>!cut _MPM;)ѻ؊ѩDR=ӏQs`!l\8;P~J?b~S"4TjלDՆ͋p7ݭhfJ#B;4j+ j nFS+ar  >dUr5'a@E~!{G:"4HuF:Z@: 6&ۖ]a@ҴLci P紸Aq!~d.jI&IJ.;][Mt*3* aqk|TFra\X,{'Zũ)ͣw\\书#&ĒvV.tZ:[P94p nT~$ШUꬦ }#u<Ē#3&wBI2LC ]%ԩ t貗d_9qq_iмwc MΥQ z+ЯFIA"AܹfIBh⻩SE7kkFarAߠWJ)ce97.lE $]%vh5;R)8éuW_9"Yg PyNTT-s2 Jb1cv_m^hCІ-ҁqu: "HnGa4:4Iuz-4Rk\K>։.i$Zlh5ChlmFJc]. 7?7LJݥmY/n W7'Ĺi$fRN]#Ds5GdT08Y3^:=i8>tlx}'qQ In˯FE1/v؍AҴz Wb\\d:3ڿF{&&mWQk,T) JRPtúHyaDz8 0hC35k2ЫA[-jH#`ٶWdqv̠"kZբ4*z+FF[\Ml{e'cOQh&+z=L%}m.l7##pmXxs2v/D웻 (=lUa4-%- Uw]i$؝/ˢ.v%曫R=GhzSSR) Λ_atMSE{4}6ss8Aq\nL#ĀݏvW΁@ 7FRj4Sk@qyaWRQ*5Ɗڵ kk#>Tm_d+v3HnB5k1 p+^qI%~MMS~}p'0Cu tZ5 ^5PX.qcd0wYs%kүL=lKL@E4v;NӫHc(i(Nx.pkZǁN OAܼZ_`{z)ѥM CKCW=4vWIF˝w @E*؆V'P˱rF"O|:ctm}t[Uzˠ4<,~J](vմRx4}$&m8Ֆě Y=^JXhZ-Jh{5j8 Hįh=;AuJ/q\1ҼdK{RtiTtV.fAu+akLrX}v8lԝ澖ʆQ53FY.t"zRJ/fSSi 4r"dY͗{MKmg靋fW4AHs'HW18{t].kiSAK)5tqָpEGv>OA{Y4T r7[6!8.Ot;Eub8P5kZֽ071}+vS #HRҢBqfƈN&\PmvIhzՕj0`*;"E~СU@sup*qXr|z^ccKԬ~έ{e쓘jrDsat_ji:Nڵ4m.-!CaU{h0]H(膭z4ios2lXm_-MϧP>ʭ2jT`GJ静tz"6ZHx3UJEP^%s6:V2m 1􊦘%"1u(SIYH iHGl-ڏeaZySeL/#&b [b/;NsZUiSTnE԰ )^"mZj4ݤ} %K(oUtrѬ!a"dv[u'- Aa9!;'UI:Lc]Q^)s(EߥMRjOSQkt9{%"JʂCV=S@SMb[8+= vKTi400Ew>LLi1ڪҧ=heI/f}m(譭Xή!ri\P*Cݎum6al:M"6#jBK K1\#rI폲:]:mj4<`e-g9]mjN v`ߖڎ6Sa҃t=JaNy1X +轛46決-G=1.uF -'d=cںM\ԉ ;/X-u zް59 g[4sҵM;kR+qb2ll!ةI]S5c@6_m5tJմ }@tzZjJ-ڮR*hs>tV45FdZl^`;MfQl[z}cK˚1Bv})hfTNibb1b{_dFTk,/tS5Ϩ=.@E{Mhzf <`)V_7E='9ݐt5*aRCl;dZfâ ܁>ٝ+Cџ^ڔS ȌLFЀvݚ mִsI$ԫڽ-5*ae}.EsK[WW _3DЧP= V dkSs5QԘ%Z$4ҙXixUJ5 J:*?yi"hie.:p6JXֱ\"Ki~USSўb9@'1^}JfYYHҩHqnd`%BoJ-ةEP"헲:c]UϬmmgx@9_bit4Ju 40k  rpY4bnKۍűQ-&q %U 7YEk.{@ IVvM$80f3ӡ]+r]^:m9$Y"MOӻ:WH~Rn:5jaնϭ8*^ɖ":Ff3{G4z髊s]L687ߌ$a ZԦ*4tiҨ)Z3rc*uj.[\f|O9+{(5~=icM=\_ 3ڲHtR_Y TҖU<~|/|Q[⣉UVU]U@0DEKl|^z%Kl|^z%ѥL37x^+iU4 3WDD@DDDDD@DDDDD@D^"ꍠ4:%kv U;?HM.`D;#$[=vKCQU.j.SM$ԫԁu[ MفҽnM4ZѩR5Pۜ M{"]AeNH"H[='Uqp6e[5v=uNVf:u&E÷Ⱦe{jѨpШ2[V642JIꦐ0]c9̮sCF# "#m6\MJ 4S֝M- R4uR47Sn"TƴĒAi_TWE)qcZd@I{o5\u#4Q{]M PKU:ouJN@׺)ƍҰu'm}1PֻK@Ҿ.4mA+jSS4Uyu7T8.ebDfa R*iT1 `@.<7@Ed2NR?6w6oj-1]ӥ7K Q~UQEvRugQ^{-&:j~f*8*;6R$&MK5 JtEU: 1acpp/"Su@PѐXa}cUWU- e?S ,XG2%һ>2'Z:61Pڟ5Ƙ\7ωMwGôFVDm@$ԙxti R(Ysm$/nPh^@ӫY)b^)A[Xv//ARjiԚƹڌk\ (ch=vI)sXWJv_уȫM=ږ*W )X:"#vyjSuw\ÚugmzWNNCK;\щvO =_WGdK\G/[N*>:TYMT9gaܽǷM"k4J:a{+: 3齴TZ tj6)K@(,ջ!R}GGV)Z^Uҍ_Nsu*5S & F+vWg:4QV׶;+-#MJ`޲feJΨ2b p&]6?SJ׺%mR .fŒ.TL$>6FusadaW8IKunCssZS*pqL.TIޒwG mr \$w-ֈnnp% [= *pqL.TIޒwG mr \$w-ֈnnp% [= *pqL.TIޒwG mr \$w-ֈnnp% [= 0qQ'zIޣdaW8F6FusdZ!;D778nwX'/0qQ'zIޣdaW8F6FusdZ!;D778nwX'/0qQ'zIޣdaW8F6FusdZ!;D778nwX'/0qQ'zIޣdaW8F6FusdZ!;D778nwX'/ʧ D'zr \G mGqh2[cМ D'zr \G mGqh2[cМ D'zr \G mGqh2[cМ D'zr \G mGqh2[cМ D'zr \G mGqh2[cМ D'zr \G mGqh2[cМ D'zr \G mGqh2[cМ D'zr \G mGqh2[cМ D'zr \G mGqh2[cМ D'zr \G mGqh2[cМ D'zr \G mGqh2[cМ D'zr \G mGqh2[cМ D'zr \G mGqh2[ZN_GNn)ۊ;N# 0A0۫$% dZ!=ksǡ9}ENn)ۊ;N# 0A0۫$% dZ!=ksǡ9}ENn)ۊ;N# 0A0۫$% dZ!=ksǡ9}ENn)ۊ;N# 0A0۫$% dZ!=ksǡ9}U8]n*$I;|#l6 [ JY:cb]e]K~% ،,,;ZtSIsu˻wqhvpTCENn*H!wޓ+2WP@0DEOHjPQBU}'xƼc<4cv?ml.P_;G|j:QvUcߣF1bIn޷i:e=-h"gRukqX8,eK1 G!X=>3gҘ])w0/ӳ=ʕ8Qu7@$O+:?i%+4<Ɲ*׹^洆$p7acф1 G@cgcS &{ؚҟb,u3p %R ncv?m.όYwǨ/L#x_wjUQҎHRIV" i0T4PcB,s52:5:>ʸ; z@79/؞|IάZ@m\!X=a n>&?Es[KV@0 |4~F:5] *cv?mCd{it6|f:ϥ0=A|# o _jѪhnʭjV`s)$:.qֿiZu!T&e:/kJ$]bin K1 G!X=>3gҘ]-w0/TNm][*)q1hxtմ *sSyk5O,%Ī\!X=a n>p&i8l x-^i%T8$aasLR ncv?m.όYwǨ/w0/vK՚EvU(қB& ts')QUU*i4FOGJss*\!X=a n> # w}݇U֧Azڌ%8Þ[ +?0`4ߏYFQN4bZ)_]R ncv?m.όYwǨ/aL# ;PR5!;YRo/nhalLۭ=SI0F7Ul'%K1 G!X=>3gҘ])w0/ԎӪԪ)RT,҅ ׍]BFc,D]Fi!fK ]%=2uuVb"%R ncv?m.όYwǨ/aL# {P+R)KU 0vJuN;t=V809ԁʿzwVQ%5$,TSdSk6.'mWo`$$*!4A"F4JVU̦\g8^%Vum#Iehk\{]!_ϲ"Q:ت`Vqsi_.`'Jihq@.4x??}MWXRUMJML''Ẃp[uc*ΖS 9o1蕆m+Aҩ65h潵9"ľ4V]~34}zBN!b^;/&dH_ƷEMJns:Fob4GCnP-ia8cwJ/n.hF);GD' N.is+wGtztZL1 Eɕv աOD#X-Z}ZYux<0ڀ黶NvŮsDp=ի汌9*j\\@{ H9F;&AƙiNiipp-"a!JZE$+2ZikY{7ʾ "?fP΄TkRs/u7GGWG2Ze@@@X&~ ";k ENqbR;z^hХV:%Ui05 ML@m_D_vPTv=2Us$/оFe&M&Tip+{j\HJHqiџMˆmSv`ؙ+]WE.4iQ)imDc0EbOt nV]~d+\%W$LLѧΪo̾{h^Q_NiC]{Cf΅989II`$ӦwFV5eDD@0DEI&'m (єO&͋F!Yy$Uֱԝu]k9,b7Gޥ'֒02{cyʳoU^1`=jY,FoX f*3zq j*[Xu֘GZ.K1Q#0YޱA3ju֮KTf ,b7Gj*5Z+`=iuRdb8 %Mc;֪GZ`=jY,FoX f*3zqxzXu֘GZ.K1Q#0YޱA3ju֮KTf ,b7Gj*5ZvFb#GJl0[ r%~@>e,TJMpv=2F0t \,b7Gadb8QW=Ig|:L=}f;IK[Ix1:{lXihh4ښM*ѩ8a\L] %Y,FoX URk=FVGHmcEHs[i⾆& ]+E,S VNvܹ֘GZ.K1Q#0YޱA3kT@vv3J}Z sM?[Q^}z&ZT]i6oP<㧍0Fu֮KTf ,b7Gj*5ZΙ_c#HЪ[;l'Y&hg{n^=[4jզH$j8IǍs0t \,b7Gadb8QW=Ig|:tJhRVM9i9v/[jԫeAMS&K6O0t \,b7Gadb8QW=Ig|:Fgtת֭^4Mm"K]ID P{~Фm6那e=%]1\L] %Y,FoX URkZ]tt{]hZDhp Wa!-1s>%=v[[Xt]SkbrK`Hl/`=iuRdb8 %Mc;ֿB簝ҋ4Ttۤ2,s YWzZ>SnMKZHve0z:)pYޱATf E^&_ۮ)SkCMv N\]_%+3G2kj? !0z:)pYޱATf E^&_һjvV"?V)lc[CK Xx-Y۞O}J/,m&8|V/lO*e~L] %Y,FoX URk];IxUѝZѩm[Y&"^'e!BH.5M'0cGZ`=jY,FoX f*3zqxzXuosNq=eQ[L] %Y,FoX URkTVz:W@f*3zqK1Q#5{ԚwíUz:)pYޱATf E^&UEl0t \,b7Gadb8QW=Ig|:Q[L] %Y,FoX URkTVz:W@f*3zqK1Q#5{ԚwíUz:W$LLdb8TiWy7uyy7XmǘXڷ.e3ѿz~GZw4[؀=@0DDDD@DDDDDB<1t :݇I/Yv. A0BA>*}Xˍv\oIsC$O$)L(Rܚj^I/^kwD⎈f2Coyĝgckc]kۭ5C[QZb/e $]0P Ȉʌ}bo1Xe.DDEW&(Nb!RE~kcF}۬p>Vȧ2ɤ|Dcɺ5^Umמc|#>Hk)[#;.H͗2U1ҪB ),ɼqˌy1;/rasbuF:ˬc̻q _-M%@5כ|Ϥ<kczgvKA@Ja#uMXq1vk;R#3iFIvha XCL B+DDDD@DDDDD@@0DEK66VNC(&-:\wÔi^CoVl|^z%ѳ6-̝fIa#`VA%%ZiU/(ҽޭi^CoV;s}} p in֒ǭz4 jR5 $H2Z }t=v ] Nŭ0ETJRzQ{) [K5hB`϶+Rǭ%Z{O5Q榍ZCv_u >E~ԩhFaf:†7bF ;TJRzQ{) [K5hB`϶+ǭ%ZM.t*tZUwRh#)yuܑev~<4[PWH:K4e!{hWս\&b7-z[=ѬIգԥ{HTN,&$oit= ~4gbqoDiR+Hm9F6om.;s}} o>دw=kUHu CFG6mu7TO|vѢӭYu[@q1HoTJRz&RTyu]q6C^Hۇҕ=-ly x({alŊǭHLAJ9ÊM澛k|+ZdU m]oty9RݦDDTRb=vTc<5%{bf[8?|7in 9aY,9+j08\%{bf[3-rOhaw}V:H_QSpkYȗ;˳m-ҴT7刋߽R+2J̷qˠ1?Z)x0:׾a{# ToW!6zksѡUMۚW&e30퉙oח@c~S "zGZak٤'N2}v;v:%ApmbW&e30퉙n @c~S "8zGZakݢvOәwf&cVb,eGsYRb @`tʥW&e30퉙n @c~S "iuS]ǢR/q־d뮱yAck[-a"J1 tQ˼yYwq2洍FXa. ,Fs@&m[HPD qRq⬀Jꨈפ"0QOC>~.Hk˷kp퉙n e;wBtl[ `6vVm8fi8֎ɼU.3- ^ؙ9t ~U+aiu[يZEzBz;I |Od+>MAd ' $i* ^ؙxW&e~>]yHL=#}3ez-K !.~ݛUhv zU:uhN86="p퉙n %{bf[Ⱦv֘zGZs:TO.}X݅솙@44wԢ 툑ޕKlLpxW&e~>]yHL=#{! tz i[lLX Mў0֜J ^ؙ8W&e~>]y:H_GGdtџQCq`Gtj%WQNsi*\%{bf[8#b}7q)6NR0?J̳bsׇcƝG,dKሽz?nU69WfdVg8qUVg8qVhy;{Zd‡5eTD@/[ӣ-hDDEQCG%5n >\W<7yi2UY⪀5e խت} \R"X86 nZ3Fh*hkP;Xa,1Zqe~I~MUJU6Ho,%6gU׵$`ivݖ_ћRߦz+)Qs*\kH_>m:5~P}M:1`|R[saz4^ih:t 4Ɛf޴` t^{A'H+>R NS0.#G/^i4104⩫x.$ f;}*TY^G`Sf.̑E–D{!3v[w_Z; #CcAC&ۂevlѝDi/ +10bi!j"2洍FXa&eWEYi?.!OGbq:Rqf8w8V@5eTD@DDDDDTw`"襐Skt)FЫO>rUY7 ՗Gfiv-:*ӭOIu F05~GdٍA{"M#Kv׆Lryv_D_wn( !u'JQ_Z#jhtfc}:F@I BgdtD14F-WN+;:h&ZY7t "轺RѴ7I s~#---dfr 蝰h&SGfڴ0<".}阜"bE:NtM /u8xh;t5[MTpl@Z#mk "NߛSIz'<pj6d۰_ݢ5=D;|_WBkE F5k5#H}Ni\vBj@XZtIz;!Q4Q‘~<$܀my X`=.X`=4!UXsOjꨈ@0DEKl|^z%Kl|^z%ѥL37x^+i{)XXP1΂S3/-⼣x;C؍!&.Rdt ]zگeU[Aʄ cC 8z?k]ZMaV3擄gAqE6S GF!M4i Ţh߯Y 0onj/7McisM!=vTG . qn .v/K ) u֗@rbݹiT:=e/vI6HZOzOL m_=}7t4FRmS8b狜n;9ÊC̔z%?w09*"DDD9RݦnB""*?|)Cp^ҿuΫOy*ꝘeN;Fmz.t-`ksD Ys]CZgbtNhtCi}OX 2isI#y ͥvsuꬫUM:>@V܀hU}}I厃W[]}eF{3$t=*S.S9u yǂ|뚌.(yY ՕQRk)ߵCYNФ]V*B>oʳoUgd =vckRcz_707|ZY~Dkh;__Uh08L/NafZ}fu4bjȣ8I1_i(tjEQZ8/YdMQ\AZ*sc~ҟe_LmkkNa}95uO v@Lj=|?N}@i+1 o/³Zm67I64UpxӚݘ겳!iPy{A5"z{ٞѤV+Jv&h ꍉMNvc-tYAxvMHXi:I7S"ƛ+,{i4T]GTCR$cdz[}#FA jZz3QM\0dh{ZѴn7OmJ]:k\il^__;WGNRX5IQY^0pP ,xE-nag{İҏug:NcEfsUfsf)#!J~a(sVUDDrM:9RݦDDU?/HrSP#ɥ~SwV1+?T _*3VZTWH~*uG\&>[OǹTidS\- /apt7޿m4?EӥхxԲuY#;_j}z 1XqcAan,m3vg%4PVsi6+TӬnهb0vwl[_Jq2XCFx3i+~ڋ47M m k4zt@I޸ @".&/b4ZMz=:Mc,PaH-̝z^ܻ%ꚮu]/ITIs$@ENi:vhԍ6F/5* aq^ڗdݤUуik I%& )дv)&Sڔ *mC֐^v^^-*9MU2 =&7_s\CH *+T=]yY**̮kHou fUtU\֑C4d|1* *]}Q54gs ױ؀nzIѨŃJMgS8K A9\jHKz3UV6VIi\Ud!CHѢ1pUտsˌ;c7*h-яǚU@sqnd_ctk˚1s]k^%;7_N겦ӧ{) cf$,WEyE,WEyQQyXsO9W@5uTD@@0DEKl|^z%Kl|^z%ѥL7x^+iU4 i21Ęɠ3V[v=RK*!;ke/Rita]\Zi0mx_Ifc Mf4#ixđ@YF[Ie};4mw5 R o/vh􊢍\5_NZ1dghJCCѴ_Su,?1<b'x iX$p'<;M}'vٯ^*L[0=$cD "h2VMym n1儐!WFEɥZsaqv (/Ҽi?d]?d1j+6.٪@0%xſ umM\&3dU3~$)#&\].N_@:UUKGm/[-_C\IxvCIP:7 mftrb ]?EIһSyl*,kv͡i&M~(e:14Cjs@tStSktzTM6u ' o1}\oT`,[vucs1KNJ*""" """Skt)E,X;H4UZ|gd ɼ.iETt[;/3H{ zE:,.sk\#Z]"<~/t胣ѡVz#ac߯UGd(ƳEU5c7 ދg|>ԬgV}1MؚDȠ"ƕ4ڴN *+7ջ^'36ؼWc{ h鵨45ඕv8N>V(s_~Mz%jtQ3؝>Z4jhYRl4݉؍Y#FwNcQl `3%v:Gc04il`| ͬIƗ nմmѩҫcIy!^|~ ;,P~44ZM시#N/e6>zf1e !siTְd%^]*i 'S0TM䃲.]5>Ap@~ s\Y|ھ/=襊ھ/=J9!:Úx{p8q#4 f@0DEKl|^z%Kl|^z%ѥL37x^+iҪR^50EP9U@Oퟲ*҉3P˄adkqW']Ee&vt/Qڿd^EzR.k5ɲ/;9s -DlīL%ԤR`2eG]vUkҪ;VS4ڲoe;SFt^j4ZD,p4_@Ht]9.^UCp%39_?{^:tr#VCMb';aNS"91@o;N#Ipu [p`P8$H5ߥ=+1V% CO&mo}sc$ 8Y@+kS'E7CFH@^vqkOI Al`ZHo+za*i="^]uBh-.t oOd{3SNҩii{n`~޷e;iJKGt]ͦSPMLF[2B70X[J=՞|9Ozi]*5 Ghp g8qUVg8qVhy;{Zd‡5eTD@/[ӣ-hDDEQCG%5n >\W<7yi2~بv Ji0KH- OT/ƍQR^8CMaOiMS:͈.4-YVݏH{5x8cW0sd1ў)z=Fkl #%cPi:m#kcAr3E`Y'Io벝f8c0% Ď#Hit\3C4mgԥ\CiacE棱Ge>GIf=X.;GR<鮢Յz*{P%ϘO iSIuAZhvZ`Ұ;AtKGeZ5lQ:tqCc {vjz.[rlobv91«6y9l)_T4*ݙ}KGQ5pG*qÂ/؝:[=MӨ8=ָűe9L*O=4:6TYԩW8D '3EeWEYi?.!Lʮ+5~]bC1Lu#1KNJY ՕQRk)ߵCYNФ]V*B>oʳo{J]ΑV[7 tBNɼPfyvѪTi@}3f49zW;=ѨQe*u-:ruʮ7p_[贛[HMCy~Jޕj+SKM9๠0'fWl5Gi-=QJcƋK^8kco]e-<2]L6cUn' p*GZ`=h᎕UKp;zW㷪RK>+CU&1;`=jp[oU|}1ECFek1:˭ݵfԦvF!q`=jlIk4\"ƱcX tDDDDCږ4""/%xhh,cvgo1vy,p[oU6uJoqqaI<%@4,7|$GZ֪ 5v_0[oU+x}SWVwH ~8F蜗.kxa\ޫK ݇IZ9kc^α $'|8_+'F\6ӴǵvLMBHcy$¬¸ oW+~)*G7Nw/v`o$Ͼc[V]  pV⾐*86tJ}Q? s9,&U.kxa\ޫKW.ov9ɝײպnudi h\CZ!Hp[oU 5v_]x}H|: ֪֘)44maWc.XMp *\}D]yט<Ʊ]cX=ZؼϾfIFPg1֪5dDDDD@DDE04YpOrxTMUW"M۷]u簙p;z.\gFB7*dIٿƮF "2ޣUEKp;zW㷪Rx}SWVw 9`b TEKp;zW㷪R TCWK&5 _5#J҃w EKp;zW㷪R\j^TUqָXƶ;|c#u;1kXǙvnaǫ8f'ޥ^T&'/4.˹7AoY p\nwܬZ1B ­¸ oW+~)t m+w*Y)mj4(SK[-0 sd FLtJ"¸ oW+~)t*]!*GZ`;Z*\+~)9٭&B!đqEDYuku3"8ZA sFxհI:UJ興@=1x2뷮&7K")+$ǟ]12[ceqMM 6*caP4GJ-1K8qR5^ɾ1TV']qQLqR츎({&dzQ[Ҝtp<Τ}_1st8v\G_T.#N1TVt'@2)Ħ25Xדu%Ժ56]3yJ[ceqE1K8Vqs1%VC ^)W@8v\G_T.#gMR+rzSҮKLqR츎(8v\Gj}c=JNOJ-1K8qQMɏ*#9=*.ˈceqF7&>Ԫ܎RT.#/*]dlR+r:SҮKLqR츎(8v\Gj}c=JNOJ-1K8qQMɏ*'9=*;BAjyε1kyqQLqR츎)f- 2A_UH0ASNGJ\U+dԪܞRT.#/*]dlR+rzSҮKLqR츎)"E1C,cnM+t@ .18MOctD4\4DRQ$yn7D- Ph99ƘH[>bZ4G*Rv3J7S\j/v9vYԉQӢ" G_-$ 1_^QUNѯJy:ĐrևuVS+JѨh"{H2d Zga!z'F}&bÉسT'dtTRuS"9Fc&Mj΄dt=YRj<--$X+i=ꊕCXq|:u)~Q h" 9*/d)[Y淉/;>Qu=Ы_G%6G ݘavGųGn+QԴbCUI2@2rHˡ`$j2ju.xWj'Nh.4&>Lc+{}ѨTcT{Mg6$Tл3S:;Zw2\LQys1ؾ쮕OG8h-.9W=dӤĹڧF67${m^ջ+G@SGNh14au_m:M4b)+0ŤD`8DZM~8v#E^Ƶ_t|nSCTE V8ybujǷ{gFsiJ{hԦ3wˋt"*n vR]Q H&d*ݐc ΍S' 8/cjл @)VSڵbk,*@$ s^v/h:U vwQtb~d^4Z@Ë)$]Ra;#TU-ѪE>FpͷZh:{KJ]ϩH0p]dn^~͢voG&Z5TGRZZm 0D@P|jݯSG^)<ZVhE):%ȯh4uݣYضhڷaQs~m/fg+h\OFe:%$#exnTT-.&};&609S _~l+(2i= o'Q3cdD_'Q謤Qw4"6q@E&REVӌ2ux:ghki'gZ{~n%m"}EA hZ *o.x7iJ} Dez-:nOHԺ`qؗZ2 "-TѪ4 ˾"dvP=sH{[ _ۥ LEiԠ/dzsV@~ESQRZCoA@E??K;N8^vj%Bj6Z, D9/SИ1th‰ A*śc6#:S_@+)Dg: 6WVPnVE fv?(uf'2ۄ]y+ct?A4guGPqSkA /y;t_3Je7ѠWV3P :ay}F-sN`W;e.4}KUfԱN  G5 "Akj{9B2atR2^4gs⪇?g"Hj2ȾcIJ$ڪ/fs(vG Fc#1zE/!`W_bC1xG΍K

M] d;G:ŭ kIWg-p6Twv8sDbln9N[7ò0ot]/.iEF{J7a#G+cFYdc}Q'tg9Ri᥃"uPs\.;VkZI9%t>´~M5%i96[?bNJNE&`ʀQpq "楤 jz/vGZ-~}\ʓzkpɂ&ѹ~D쾇`Ht4Y Cy"Y-sFr#5aF! fCJzd>Vac/Kd4.t}vRM:f!n!(s'qrٽ E.;`N!G[SÆ/iW;G싴SGf5k,$@Ep;qrٽK)itg2n=]icoXܚnn/9lZv=Ztz3-\ꀺ)ao!Iva=7› $M.C=-z44M /JkL\Crlt_tSjh5M\"foU\H :lwd.dt5Ϫ;G\ ڼz'g:-:Jt  eA$ڀ8LNC.z.VH>lXH5,UN{:8 f級iyv2@È'!<E@PFR9ڔuIqcƸ&@^N-vQ;*Ty7}a7Ť4H0|juU$ $2FM~ػFeZ»h cэ`4i/>i٥SuZutmcCXDKHH6⫁qa8f1E齌AIvuiu,.dS}*ncA)$W}"漱baAIGa2ZjKA,kib߱~+]2m/HߎGD d@(R2^.Z/T39oUP_Y8Ug]UODjD XǖEDםko=`7\HPP!q'^yXw=-ʈ@֓%U0GŏZLG#U-2r8bQR *p{#֭NGJ*[eDqE2r8`ޯ=Vt#U-2r8bQR裥ȩ 8G}bmbyk)zeB7yHnԮK4Xo;H[`I퇥N1TV=I z)yf-iKuSI퇥1Ǩ7yHnԮK4Xo;Isi8)$:nF>(Ƹ35.uUQZ$$]UD] JñV}qg=KuS.zU5=E_$+R-0[N9f-i#R{aSn=EURCwt ^Y |)G,c#R{aLcq* z+5ncAjXˮ\zf-iKuSe2K cUsD70!RA[QuǔkqQcH}, 4]΅}2ݟŸ"; C~C]ĵ-i"^]Vi:)vF:9xsb%qŢ}촃P'qj.' WݲԯF-/F.M t ,guiQN*2['sqtM3^VzԴBʤi>Mb0F'88d7)vSGk[GDƶ49zN',;sSK-&jYBuւE=Z ɝRZD8SJZp{Dg%w`ѥ\iZ׊#N_oFHjU[K}wRp ۬Njz-uJUv'K1A;7[E>n!*2)>1KA͍WȂAWne2DcZϪ $kp_qNRrBu^H1:u^H1:(V^6…frwjʨh3kxE-&aoҿtwZ|Ьp 3V_;KMU-&p[M#mW~{XڍiTypÆ+G4~3AMu=(WmpcM/^tZ--L5\I{o!% "e;CtjCh2jS 9恸; i5m*,th^M$IE}&J4hFmZƛC7nւn@ڴ{n4J5龅*4溩p0bnglюM&Ǯy>%wJn-,\n{"pkF"Huj ꎍNtVgl'j{!SOfM*hN [+ "~ʺq@kM>O T X]LJ]vF\1iԘsC\dmM'U4hݬE1Xsfקhbk<UNYlO[:5J74 |pqkpweM4M1ԴF Q)cdDi^eEMߢSua$Tл8xմ{)CR1LDmdT49PVU0\]&W4:z5pV88ZH_onK4CG~J.s03%'[bd-2X).-i$sW,on)hXkX!{ߪsxV~UY8t3VUDDDD@DDD@0DEKl|^z%Kl|^z%ѥL37x^+iU4 3WE.'AwcLIՎ % ʱli}t\t>-F1Qh4b81#mBhtjIkYIc V^CF sgctڬeFh՟N,/m'%H`09~F7IY]H֪XLJңhtIڕ0}H$a{f|{)_Fʚ5]FO4r)A9x, +ä{=_һSV:Z-6dRi]E$,&)>)nU)Hqʍyk ~>SDgb^vOBGLidԧPqlSp@rU4Nu]+IQs_{ @.OGfVp{@n:pZi]XLᤒifz!shEJ/5FUkXv`B>mihZ-FPi]/pp ^:v+O hCq(ISH7@E-+m^ǴTm&U=)as8mzb4vC'BOF{KU<%['J/dTᵯu毡:(aFQQ`sw@45Z6{a¹$5]G# {q/mU]JI6i! 0HRrJ=k-!rAἬD_bNM*՜I>$_һ &Zihc٥W-V꩸_8/-~vDoejG7F} [3;GHѰԖV/uLm&s 12 .ityp^洁4t_ Z+77H]W,onѽ[O9 +?1*?gjʨ@0DEKl|^z%Kl|^z%ѥL7x^+iU4 3VDE{ ئVv:(*fu{#a_лgѴn{.`5i1uK.#" Woi:UzNәN ^X)%<Ӌ)WR]9 uōHłb"~-Zm3vJ[7b{ޅ۷c@$Z5ϣڎ_SN"VgD#N/aViniz7v֚gR詉HkL (O|EQ~u-5s"6v٣hkSjy{*1$ڿ!Gc~$+"F`s{; ctUQ)i<L"5qџU[>*譢p֑lH"z}Ꚛ#MJ,s!RڮjtEZZ;ޫ30@+hݢ ":K)PqC|8qKb "ʏm=> ;Hj 35aѹ~1onUc9 11&:R_4ֱB襢ic}cto~yQY8UgYU@0DEKl|^z%Kl|^z%ѥL7x^+iU4 3VE{#v54斒2Ә2 "/S.Ԭkjibkr"$oGvohIyijHgSkKE)bQiUwR6e@6p؞ٴ:˫V&H䙎eh٥k9Aq_һ;zCu8~,p ҽN톃VGcQx Q]Je[$8Sn. q2q?f:[0 4] $EZJ7a;'F*4em=i`q`asKDMPKbKAe(֢u&(6<5 ri@EvFu^+fItΫNA:3׉ Yy#^.Yy#^4QZxܝUVnN/T(SS娶1>9>[k9-eiq_&9ۭoIiSJhfI2> djbs{Hi,Sbƶ gby33F^ݱ`ΥVvEfA%169ZH8ITMՒyyם汬o5;<+Ҩh3kxE-&aoҿtwZ|Ьp vN8yk49H@d4Z,GHu:T5l ~T4'VnF1 -e:ZGUo j7E}%>E_5aL-q@';")j}P^5dv{-+e*Zp``e{!SS9Ybղ6ڲыN,/٧2hD%Դ ё L{;Sm&״4@jsWENBP~ILS,z3{ iZShGњQ*3MH̓>k@gպV0a/4phOLEY͡P˩ 9NZdtm! 6;917Ki݅;Rj4iiT4g4iQ15+vtƊ6h=OQ`~qqr@E=OҴF9*^d᱘-< Kiio` Ϙ ~[Wh ' 'I!JL0#`YV?z՞S1f?HqsvYjv#ta,-nVc: ^^vQSXlc]38R_4ֱB襢ic}cto~yWUUV~cW@5eTD@DDDDD@@0DEQ5Lט̥k" -bbq묽k=:qiKv ! h*$N)UQRaeݰraeݰZ{P:OZ'qNN⪊ s/ܖ탐 s/ܖ޷ڄzչ;rwTTk~lk~l-y$ZŠ㧰 D^_#wr׻ip9xk!O$mU ˤܝ9l܆k~lk~l.Mi[B֣'qUEKiKviKv i[B`=jܝ9*^CL5̿r[CL5̿r[@kOzjIV)UQRaeݰ\"e3y8'}<־\吏gv^uLHhe׹["Kd IP]uqYf5鳻>15e5 Π*SZZQX^JO-UtK`]Fw|>ϩ4Y'nˢ^s w^ Qꐒ5>r%ݺ׮7ˇI̯=TdUU$ K@^DD@DDDDD@DDDDD@DDDDDT_̙ns 0ati_;>hV~}IjӧGuJىւv|f+:}VaN "㫡j[ѡJc]u6lx/i:C .za{eA/ԥz桵;,Zy^G=& >31tٽs:ctm,sE=THjAۻp/kzF5.sy7^#}Q1=wa RLs($w*]Q@Zh^zy;9*=i[tvTk-ft "CoTiUm eRiZ cj:at\YY; ӧۧd6G2*='!#N `].qץv  5Fks^C^Z@TӆhuU--m0f;qW,29cjR#01*f!|vצ;Kh "!OYƆ q$g "ڟd"R Tc0 N.[{-E1R/y! ͤtɝiQO)vy;}v:V pui.{9Y@B/Ի%Rz`S=Z&-OV[vk$+Z}JM" 9XN!/*mZvLX) ;/RQ_4ֱB쥢ic}cto~yW«LҨdX măPVQ /qq IL1+" """"" @0DDDD@DDDDD^d!ԆU:ꎵֵǚkưe*>}gyֵ{"ݹv9.qQi`sKr ;L_M~&41]D{*G1Q= tۛLyҿ+-|-|R5t0>7$M$$]y=4ҩU&i.|1; l'b.TxHd[1_rmSX> ,xT6 <<^H&XW䥽HLF}+UU/ICKuTn-:4l_g8qV 8}/Nږh'KSE-kqTv^e; -]~ &~3@L]~ݪh4 _[Psj6XHYrҟi4Z7jajWf ]~`ߚv^e; -]~ &~@L]~k'VXVk>p1ʘ a{jN 9Ռm4_xMȩpm]njvw@k߿= n)_@]t}L3GViMx>_Ȁ-Wh+V4RT1J"lMx *\We[GIvo1k\qugnsp=1i*fY/p(4yJ.@_лSѴӍzT Mv's o_~!h LCQUaSykZ]i`U~e4XZ"K9A#UYUR2f.Z/L795>hV~UY8;YZ"-./ ѻj ՗hд~lt' [c-<`p_W=h>PBFQa4]0&{tSm}:.s\5NøNeznԝСZîxik}oZ;a@Ekv Z&Ƕ &흖9Tۏc iԎ6Y낣E9} &bK车Ut=UM*5&N4`NOkKzb؀h:;=@_ׯ mVayS 5XaO.\Lf;Ss{;!WJk)tb*;h/^T]xI-c00]@ЪVsۤkuk1:. m5}V]]a<8gP\=2mDЩѡL:*UYE/.y9Wͥf^NvѥF0ľa _FmvJ^tʔTkD b$T)gn"mjFJx@1o;T2JZM76Jp:5r` li4*]*쩯m) UDܐDt"k={ WL}}iC[ʙ;sG|~i!M:: ^Nwif'JfkC~}p؋#U: c ^8qH.hR_4ֱB襢ic}cto~yW՟UV~cW@5eTD@DDDDD@Hj2ȾcIJ$ڪ/fs(vG Fc#1zE/!`W_bC1xG΍⾓9밝E1tLI]I^љ`<ԀWg%V= V%Hs8XִEŊM춛1ɧ8mlܐaޟ=SE(jYRi1`O-mA4i_4OZ5j(-m* i fv "?dL_4)N;n[&Ge}p\u4Ve/k¯d6Z!G'YH- 8 =>:> KqN@E:=vGGugRkmZJ2Fv 'd="9ΨZ%A[n:gf{ h.ѝI`Gp @u!/ڟe\l` h eZ9l(9k]/LhSa ZfcVmԴE=$pM:dE>`tB{a#50php}{ Rsd4IjӻUktSj %g Fb8>$_?mOchitT5ZJLu^qCm?ˡWBbtzjѢͨ' k}ʝ|}x4i:y&#B`A[< *$l [anTRކwK (Vxm;>evJGu60 L@ET @u384NP)h}F+Lti_ϝV1[;MҝA9Pa5i6`*Y{t7OYO5c{$u)Ҵ+aW=l;7/P*Uc0cE:NcI$≀M;ٝ]=:ZNR45f*@ylހtPcZUl!XG(i#z̏TO@;rvn_hFB3 k<*;ۇcmSv߁ÃEppm&~,s\A}aMGtt)옩V4Q eLE@82m}NsZv%E*ebp1ʍL?RkKn(%"a{F(;Gkkҩ~@{Cyn#r{WmzQңJ\\)W3IEZXeLf'5F8Z v^b;]MMԘXhF;MNMRnjC̀0ZhTm~ƚZ:3n"7msg`DujWHhvQcMps[I_KOtiMS}OMWn\&@ox-3]RhK8 0Ó_:l\ki Ol6b j_ۇecM~,L}niF@}zfOCvl g leM/+Dݤ:2tp=Hs@xlݑ4=N]OWuNuo8ퟲZM3J龛2EE`LgE=Ǧ3"EL֒%g;Y:,V*u<-eFL/ht5{%jMʅ5"6/3PhCY- /Ɩk B{#Pkx/**0atR2f.)Bp ;д2Zcs#8`l [)7_8t{!QZlqu&j_.B:ƀշs}Q8$n4[IN:AK\#mvWM]E=*kj"$6ORvC]RaE=[2a鼔^ڝIGId5* 8Cbn^]3_b;%GBmn^U\YX1,(PeSs:b֜1~ gg4?IVsM]XưbEt.Hһ% o}mAIg# :/k'UM: {^_S9-9ǥ[LHGkhRUw;obZ9`iʧ6<2M{ڽwf'1b"vקHgJѴg|ƱԁќcZ:O1Ā# UcTj>ebN4 E(pƺhiE/NV>=e7h0C$7toO=.J٤& `h |SHs>kƴ ej}FYhU [ LHmtZAUvADYQ,E"<[WXZ^KJ{kQ쌱( /06A Ni4K#LڕN^ӈbܾKtHӢꔚ2 JW,on)hXkX!{ߪsx4kՠ뺕G08j՟U}W}G=.2U_W@5eTD@DDDDD@Hj6ȾcIJ$ڪ/fs(vG Fc#1zE/!`W_bC1xG΍⥂\$X(vgպ5wi< $[QJdUm \Ur/FjԨ\5Ah>kZ6QP"ZwUYM~,3ԿV {^`Y>.u2sG@E_bX4mE&7K_OJ^Z^Q)Fkh@8X/5C𖇻q7oVҬZ, (evЩ6^&+i[J^X+fC*ioHU纫hع\ yb gެ(NeCf9B..XpĘ ˃ y#ڧct} z%fIh7l :mvGҍucjvvGE:ŕ[bjr(EPClڛ-+áv}t-C !CF!Z'&:=#@mLeގ ]sǖqkImd*)oCs ;%QKzY,4YΫS**]M文 (g8qVhy;{Zd‡5eTD@(}F+LvR;DVBҿu:>cxgԪC7d{!LtZ SapB ՗v'$S ko]חCk;gԲb{7B:;j:'~MJ ]Wgbh_b; ]m CMLl6[,B[R0S"D[h@E}Zzښ>ֻD\kR un3>=\(S@CTK_Ow9_gbtjE7w^.wB?d1VokbZ5nNXi؀cznmTX"{ki9$,8}}zZ{O\ZX4⚆.ENɹţC\*j8>Vf:zw6;6 "aiv"*ԩ*K0Qk `ThvkCwbQz:Cc] Q!~/#Z#EjPn*պZ,o`;* t*9m@E7bc 4q&RsjCHShҴ6mFz`hq ~9'ScJuW0nn`Z+RdԫJY(*4StZPy_zc'r㈥;$p>TVս6u6uʌzܥ8޲w)N8]KUElnޘݽ[߻g\_g\7S0>'r㈥;$pЪݽ1zwθwιQoY;`}N)KwI~폡Uzcvo~Mq~Mr޲w)N87S"|h><B+cvޛ:5Kk:7SXr LE+zƵkZI,k֗3e*!NFs*?gݽA$ """" """Hj2ȾcIJ$ڪ/fs(vG Fc#1zE/!`W_bC1xG΍o4MGT6Y0A;fxv7]TשKHnH`:iŎcl((~=Ѫ{UG Te6ќD.vQlQԫB'i,n9U- mmݢvZ=;HҚlC"hN!:gO~S@{)v>cLh]Q:ϊ;J3GQnړ/ax% Iے(= NLV~3H;Zڐ[\оΉSS[IQ+T}VR7bo::c]t*޲)$1h^]=e*HeWiUi`RnҴzͪZxxYL9K[py17^*6KJvdX)k4CK!7(TRކwK r70XiGoV1 +vm* \ڦ65A2l,pQhntl.V0y\ vsf)#!J~a(sVP"""v2KC4Ze J֧|R?`{dB**Uu=0W=ahZw?>vCOTҩ qV{Z67{LY}*ݞt^Se?\IX*lP:^&`[ ;rtloS*GtҴTTV6? S f^LsӾcHhyl(ݸhݎ{tZkXk*3 !l߹F^GWqY̨0֩ksHsGcؒGR*as- LП&hBVpz90 g\NPxvNnȾ*nUX潚ƽ%pg`h=P";MkimQSZF L!{5٦yQ~tCHi׹54aENW€#jU赽N~OH7 D9"gWI횆=M"* h49ivغMZ-S缱ė3|yMv;HuRxé8A8 WHQS5y_[zwlLXе$Vs(Bfť⼕GA-}f;H4ƁRKu(r,ۈ_4_u,]v]cK5jg5UgTVDD@DDDDD@DDDDD@DDDDD@DDDDD@DDDDD@Hj2ȾcIJ$ڪ/fs(vG Fc#1zE/!`W_bC1xG΍Kv[L)UfV@p:#?*ڇe{7:Ej}bq+ЙT5ڣJl05Yc4-L]VYvD19;v " 4)S4/lj@#dog(ʂt)AՋZvSBnCu05{o :_kkpуKhF]}&sq^OB/'iҨPF9 ]}=.]]y _ћv/KҴnc%:b^)rKʃ"i CDYmgWX):[R'7 "{7&e!T @ndV)7lwOMd Svǿh-s1Xg$%1izokҴ1+i6sC]R)[7 t"ǽN[DS]^}M#[-X[/żKi>la:6/ +KCԍiպ"hֆr:!iv3W PWdMLI70X[J=՞|9O~9ݘU&֌m.2'ƼL+mVh#M'5ŎZm9ÊC̔z%?w09*"DDEKC4Ze i"fO i+??^ :EjZ=*ƙ PI^WԽ=}*ze iӧU. F9Zr@CJдhMM 8;߀ؾieM &jc CLL9Zikz3Y$0w YvMOL~fu"\DtezX&2*{5Mvl8guIht3k3Hm][n\wFҾ;Vζt9ilցňbA(vJQDUE֗82 Ǎg[O+Wkq' ,L$ѻ\cT}S-h}GTmCi#ȼwgkS zmJ%Zlkэ{ZZ5.iϦP~'U5Xo>n.ӽt]%ќ,K,4&wleϭgcZ5lniեe'UWCM"/E[XT{j# PWj2[' ;~ɠ'hM'HcE1ZniyW+עvEҪm=t{b@!HQS5y_[|A8̑d3_nhݕF.KDL͙IAˬif*CY- UC9x?x"""" """""!F:@\cMqDq˭v頙tw+9Qht4f%ytǹnE"$@ڨsѥ +]+qαm\a,! ,氞x{#^G؞*3B DD@DDDDD@DDDDD@Hj2ȾcIJ$ڪ/fs(vG Fc#1zE/!`W_bC1xG΍}vJƆt90E# M W*cz?k]Z2Î:g!/=#8vףU)FZ=*4fkA؛.h1EIѩg_R]sXaߒݞ_7k_5Maʵ>ֻ"*譫AMF_O(b.:%{vZ!S4[NohkS1bcKr^O ohX "oNJjb0T{Q-qI(ٷ9Z^jM*Z[08XmYc >Ztr ѕM®/'GIN.n6Lt l؀1\t٩n*Ϫ u+p.擑_wIʶP*hM dn',ghhµ6Lѐ*)oCs ;%QKzY,4YΫSVg8q^i>DPC@` zWYJ~a=hy;{ ՕQ"""v2KC4Ze J֧|R?B-*Mc5`^gԷtʽiiTcYE1 YjӴZ!2êGi}WAԚ^缱ưa-cS5:KXTyZD \$I׎mݔ)w0ڰvk "{PӪ:VA^bk߅d|1hVu{Uh/Z em\OB]vF5墘^FWrίlݐCs0b%yNxC "=hͫM'zճɝ_*KK^iVas'( @;8,{'zF湮`acFzitQ;Vh -V# Cz/U~t>ӤR Ԃ44ӴJtl4yf);X,v= PpTD6/alۻ!QF(`ǵD8ߊ*}Z:u*jӤoS7.2 >vviZ4F_%[)v *SVi4Rʼn,lzeZS6v6;lC~kOqHQS51A|e#5FnΏ@S.` 8Eׄf~e4XZt_u,wGGΡ _*TT[ʥszP}ƈ;4u۫8zɝ`f^ؿ-#A`hMBtꃆ?[f~Bc*ӯMp{A9gh]mPP҅Rʁȳ؀]赻=1V^D:"IkA}K3cBШVba]Y ԿQVYxo{꾩?Z@@v3 nrB70X[J=՞|9Okh~jLMUYYJ~a=hy;{ ՕQ"""v2KC4Ze J֧|RFh}zMpZL &DOU@U]Ө1)WktKic뤑Ӊ1W=hЦ2umocڅ"A|jQŎ"2q[ 7aEV>mABg;B}Qv 9/vD҅j47UXSs R#b^vRzZZ.mGΦ=b]e{ِSrH@E i:Z#*[$38F`}YWDq1T y̘ؿ {Bwjh{-0LdXo[*ځfU07Trv,Xcƀð4;$ҭW3I4pmy腟wa~h4fSNN !L@qoa5ij֞[ k2/9-d5M鼻9L0)@Ev7DX]KZKX牨`t|)_fa{ t t[P阩IyuX\8aW4i}{Sպq7ى!HQS5y_[便l:.F P 8C0:̯3Pf~e4XZt_u,wGGΡ _^N0 }GAڔiV;\`TAw)fD+?F4ʭvE8Ktw! ViAe'zJhϭR`o{jWtCJ\S58a Hu1:o;ݵ3 k}'J:8mrNJ"N4`6E;(iU#ItVAmQ\ralEa@E;;?VKZ@ki9L9N+_Ut[<8`3&BŸjReZ5gF$ >_+ѥTEixi0fw@Eg'Osls1.8$ b!tzqcXK.wE-nag{İ*)oCs ;%{<6js2+38384f@\l9^ai~[Aa5)=𹠲p1KmF: 1WDф4h :8Z:~'ދtNP)h}F+Lti_ϝV1UV~}K=&M☦q1p  Ystw'FkE=탰UoRgdV5nR-;ֈWltWӱihj7E,X'$~)fTF=9ߕV05-ku.{#>vCzts d5kL;v}%}^;PkmvZSFjF!<v5QUx _Vi8ń^&f:;{Ӥ(z=:-n$Sc0Pb"kYуSwU}@WDL_Ko;nݻ~ҵިkv(Lҿv;V*a]DV]a|~{(굴ZOi7USJcvI207"m&]Up67 &tgd+3B=>}3D\Z[p[0sV`nEa·Ȑ\@My_zcҡʔ!/F6.B^Us̡BEXahU~e4XZ:s[/3NJNJ +"" """"" """tw+9ej6G|#μzw5QX8Uc! ,氞@ԐDsXO<9zfxR*Hj2ȾcIJ$ڪ/fs(vG Fc#1zE/!`W_bC1xG΍KNJ'ƎPQ}>-c)5"@_si6jc Ɵ0@iZfn轇tujQ^<\{rW=쎦}A4w9iDPH}:!ӴԧIXz ¬,@`cB:#tsQ bDt"oY#G^pԦa$8䘅;Z쮐̧Z;j=!)gdL_NmIE6ZoJCKbDަ[JtivR ΧD5q J/CݗѰiti:M՛P=M՝fkK+9iջIp#}'vh=HƱ=jGMgɐ0ofDg"w&|$_v E-w0K] &'q_75;7FvcIP(Ts*CcsDbA;WB70X[J=՞|9OUUUdև)#!YUB""*ZQh(]>NP4jxgΫOY*?>T"ʕ)Ř3$3 '|{ٺ݅ugQJc`0sC:V]LWу˘_d'hڔpQ k Z^:V)MN*5YJ)X$l Ҿ~#GPu:Ui56m/}:mv=="^ b,9"Gnŵ;#_I:3 "@1, 7FvۦQUhked#iM>i-PtR[slpp'(CSm/H:Cj_StKڕu4уtoA4JѴ5Vhx~ֶ[OFH쫍Z1$gKƦ,WiF"Pl,l!ڎOLm7?H4]ipPy$CE:Ocj*銁mYP8*kU5YSni>1\stwt^$Z*ak *дB/0٦';ZTRކwK r70XiGoV1 /:9Ê4A sf)#!J~a(sVUDDi"E-ӴEi.+Z7V~}JϩoZGd*tjnPp8/2/{&PHU">enTc[#"] 'fiY{Y+'8GDnā *fbE=YsA"sܿvEU5Bʔ s J솊;>s:~Bѻ!mn)Z[MtxZfِv&v~ͫIQY:q@eQ·WËD s*ǵ~̴< XZӽjhݮ'Ekýta:>kyztJ/eR [k('G4 ]â4lb6]Oe1ԧZCK@Ep&8(_KS]N@lu#=4iEiUÁN,f^LgE=Ǧ3"EL֒%ףLд4tNPpA^qEXahU~e4XZ:s[)8UV8U@EdDDDD@DDDDDC.U1g4L;T/y׏N淊+sФ5$Ȏk 炧=S9P ]UHj2ȾcIJ$ڪ/fs(vG Fc#1zE/!`W_bC1xG΍K-+V̠h4jcs |S rȞ;~Aiittx^Ӊv+Pd]H7 07ozwcW]#\5a Mg+ܼzf3CG)?sOG4*m2 /֣SGUZYQ!pVk*.e*,GƬsb>E-nag{İ*)oCs ;%{<6js2+38384NP)h}F+Lti_ϝV1UV~}J3VEf!k}.OGҫͧI.%ZDDv[5}U~Y*1Ѫ>6r We%iәR*0˘O!נB#IyZsq{"emvتZFuz4vICZV, 4'< "0;"iԤ+W481 3.;)bUVՇI-9 :/m}(}ZNִ[;@Av6I1f(dc0@l%-;NtZxxc08gzʞSR />M{[{CavݣTӻ^z\2n&0#Xf`M Bc!4WL9 D "nV^Uƽi1Z*Uf( t0ڰA= Z ey_zc3BKkZ;}nv:\K&jafB=!U.0}nvόǶ*pl=!0TTFw7;`5c 11aw} zBa p}nvkԨȫ1jo&^qoyovg84b踳y6>c2]鳺iLVGxv!%U:)pZ_w҃}(0ϵ).|u&>ԮKc-;A~}Iw{UEl}1t \h}1J 4~ K*+cIu+R`>8-;A~}Iw{UEl}1t \h}1J 4~ K*+cIu+R> CPaߟkR]UQ[@L}]}(0Z_w҃ >_ʪRcK禱nOj*wr6c]gv#}F!믶!11.x-;CZP0N#9aY+;R}]}(0Z_w҆Xi򪢶>ԘR. CP`>}%U:)0Z_w҇O>ऻ򪢶>ԘR. CP`>}%U:)pZ_w҇O>ऻ򪢶>ԘR. CPciwUTV:@W`h}1J O>ऻ򪢶>ԘR. CP`>}%U:)0Z_w҇O>ऻ򪢶>ԘR& CPciwUTV:@W@h}1J O>ऻ򪢶>ԘR. CP`>}%U:),}Ք}f_~5uۭo5%^- )iQY DD@DDDJz_Q. z_Q4im;>e jNx# /2G|AٙVUDDENvvCDnQƕ** && T ƍvC~-}6vsN3jE-`F9.)@EkvAZzAGBé9  I2q5@~: DLTъ]i-(YTRhC̹ NlӇcۣTPfO8aqGY׬Q V`f&a2dpVghZ]Gm\q,!*V]7Sev)鶣)Z\沧DSm=]6ҽP2CEBl}=WH94ubvמiE1N6Xi< 3z%xGm}]G\Z Ōn^]#zNvQYMmgRih3HaWeSLqf 5(NVsS4}1/X[Q%.# n+{Su-fsl^BƘc鵎{i4T,c5$_RhEZ+Au}%D[DM;MT4KD1i}KퟲE([T漺q4UFGӥT \\̤M&ZzJ0z!Rb:Iu .ꊎw'Eq5n aAt?RmGMv Gg^zb=S,sMK5GYI"eL+>:'\ bψvrvhWn[L9C&(mο9WJҴWp:F6;hYrE/۫ЮjiX% EM tț]ڝ6SY~`=JAr݀7U9KۣΪ=Wfe[Q^X 8_ T/vu:9CV jҗmM}QPkig{r/K;Q.( 2R:,u6Nu$CƯOT҆2t@}!@F0ֿ*d |z^5%'Vz7sL;{#>ik'Su]Suc$_IVj5c19Xp =oizFWGcNiHks$ܿ):@}:t[H2&Xm$r R;kuWSsU5IdI#r/iZP,zOh-y^ݥUiEԨme:5)3|A'dE=P>u`=؜|"s9FT5Fj̫Ef60;P}m=.뼗j=2H' ?xG~tLЛ\219`dћY|971 ӈGەmsZP7F4KLy%hlҽSUVLljM0 M0ЩVN `BIs:=vJJzCYR@`o,7F=h-ћEDQêt/ԦJK~!5G1Y '>MUZF%[r3l5jfnRqL>' ݹ@폲^j2079a`/}\M/@4KQ;`YUҩiNX-A ^33"9A|&kK`R BGdF=h[PA/gbWAQKi*.9%06;SIA[G-%7g&0+緶==(OPIf* %A=qsEJmyc I!|DDTR>]R>]W>cx+?1*?1*YJz_Q. z_Q4im;>e jNx# /2G|AٙVURq $9P4iUG @E h׸4q' 0V{[cWVs.hEm}솓RTKIҽW\,:K*wLL틱ROPҩwA/÷{ iTpu #9%h;3zD NmjG[Jֶ:D{\K0uq1 VuC 5›j pt_{蔨֭I n1^b4AM0mw:=E]OS9Ԧ0ֲ iVՆ9)1:N)܀O{Mѝ!ZLb 䘼*4n' f 圦ãSۖ*zm׺JX惍9bٌomZ GI/NNCpl3T,\K\ g84#pFՎ@DDF-@_;3v;j^TJps ;fa*h}7鶩Bt06 "no]][kez3G#&`O~nt[[YViZb gn{liInc}!xyv*,Fv"Ɠ؍;Cc^ Fhh^if7Ԧr" sr~SH5wVFNc[Rb\ێv>ik\ ZjV "^i4fiu(=G.^b47sdKgfh+W)u*f'mX@l3tnS='VZ)<KI^Y;& ^ %^׻)D;FwUZZ^!GK B}MBҟ^8 <2-$W&:>DUꗴTH ZS/du*R˙Ik&u1/&6ͽ샴_V ƆVplo+C j:fzzkyE.Y0Kd4pKi~KC~ PiY ȉڀ7::#E~kOvBJi.\@~psh>[^80әۡ|voFd4!ߩYY抆DF廱:kt:3ah79isKA&O*͗M֋vcΧQpG 4 81l_zn]fWK:ATkGp=)fgu0a aBdӵCup_miR*fZDQ8-YV;}|M^i~K "NvNh0ԻZ Iz_>c;Fxm:19+=C= t:5^]*W-r +tf=0u7j; Ǹ>bZE/׻(t7*k\͗.O=-`b"L^eݶh}'V GF*S^j&@q +vϢcGKIVnjԹ'2@E+vZM=4Iw%h:NE'RSf!Wt^4mHѫ;FuF`ы 獧W퇳j(ͧPIll/-.vFz;F i-mgiiӻN]&y<\J;hUOјIkcwŤxe)CG}0z6kvMZ&; Bv6UHVS Hiʜ" W{/hu1ݥ?I-8rɤ)jVxGG\ )FoeNӧRj O$eP4dƒ=%5ȗOvת9FIͥvmz/-Ugkhʠ(]!m=Өia /q,a{ tzN•)L0' 8cGM ^Rg7lƳUN76Cm޷A:.YiTm2 8PHE"3M`B4m)[}k ߄6&Q8^s0k:S*L4 2iqϱ1nGYrk`H׀CI~avVE|0eI$@0sY@L<3Ե1l_Z ,C춉KFSxc*{s0EYT3FpsƼ86Z=;.C]/OWYZC 5MJR's_]u6*sHeOzP#G8Re9D1^k4GUB!\ {j\f "ez4jU)93 5잖?M4=0f /|Gv襢|GvҿuUiY ՑJz_Q. z_Q4im;>e jNx# /2G|AٙVUDDDD@DDDEztTnh$E>׻)CtfXҤAf0D;|ЪXXポ &8FѨk[14'd]v\ԥzJ@ePt.hKLڼ@uNUGm2jㆴ9̈~ UR1av n\hq O-G;1v[O*qtzM3ZN's|Q7%Rfi&-eJ,ia|J9k]$7 cp3!~׶v/I@tm%EFs)tU^؍C)T33D)TX)bp r=cQisAOPZ X)<4!~jlѩ齑7F4dՅ_ٍ Aji5ti4'ҩ:Cq6&1f26;Prm[ &H1cp34ٖd+|LPvA5j4jhhoeփӡi%թT&)I9() $A3!Ԫ48`6/CBmmV4'S5CHqS͈x+kѴ5Ҵg6Z;is--d@E xi<x Ѻ=g4Sys948?>zʍ]xs&*H#tW)Ss;K,EA \ȴ @rJޓ.!MI4Zj5SַTfD6^&~\ƀSΩ쥄76@Ѐ84;e_QWnM9 }gAgVyQsIy&Yt;5J=h.[948j|Ĵ@mE.տ,&br9ݣWdbXD?YmZjZ+DFSY"`[rևmW>1sDX}Nof}JM洺`Mtnػ z52[As˃\ti.hMZQсJxeW:Lr2r_-p@3[SVp:8O+^ڻ+vV[C|Qk\HiǞrAp4wh|Ua0 g9_UǫջYa8U4 ~އA4]CեhYKO [T7[jZa{ ji{KHxײÃ$ "fVT,paŧ^JJ(3#x4-}M}-4TfGE*+83&L_;Nдz:.tgRp˫4n[a`XÓHirJtjU[`td;?:#kt=REJf]-{E6dӈk=; BX־`"6D h")T,/ qcMzJjj.8LBػN # Z6NUNVfA.{6hSxXfI.|i<b /jn7RxhiI_etNui:)(T\f5Uz*;ڔ%{~+>$_}*/c$$ogWfnPPJiŤ:fKZb/ """"" """|Gv襢|GvҿuUiYUYUjȈJz_Q.3撨zO1Nמzcy6!Mp'UZ69UKLTse#S]cV]qc5 ^<:cd/-zϡF?bz"'9=*e #8vBb5^ͽgЧ=JNOJ/#8vBa6]jzϡ1Ԫ܎R:cd/e ٷ=JNGJ/#8vBa6]jzϡ1ԪܞR:cd/._5^ͽgИSNJ.McM% EnOJrzU)y1˲GLqU} ؞TV#]l!~0t._5^ͽgИAQ᥁0Kd#"BT{C\!@࣑Ҝt ^GLqÑl!~0{6Bc'NUڼXIË)Q[Ҝt [cd/e ٷ=J*>878OTr:SҮK6]r:cd/f޳L~*#9=*e #8vBam>OR+rzSҮK6]^Sl!~0{6Bc'U\{\KI $'8*9)W@t._91˲ WoY&?bzGsXIhlEnGJr:U)y1˲GLqU} ؞TV#]l!~0t._5^ͽgИUEnGJrzU)y1˲ cd/f޳L~*z`;[v6^OJrzU)y1˲GLqU} ؞aZ.p{x!8ˁV']e #8vBam>OR+r:SҮK6]r:cd/f޳L~*'9=*e #8vBam>ORUL81h{anEnOJrzU)y1˲GLqU} ؞TV#]l!~0t._5^ͽgИUEnGJrzU)y1˲GLqU} ؞TV']l!~0t._5^ͽgИUEnOJr:RUQgˢC.@[( ,S._˼uGdn~cUVq5dDDDD@@0DDDD@DDDDD@DDDDD@DDDDD@DDDDD@DDDDD@DDDDD@DDDDD@DDDDD@DDDDD@DDDDD@DDDDD@DDDDD@DDDDD@DDD endstream endobj 1621 0 obj <>stream endstream endobj 1602 0 obj <>stream q /GS0 gs /Fm0 Do Q 0 0 0 1 K 1 j 1 J [0 2.997]0 d /GS1 gs q 1 0 0 1 74.3631 570.8533 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 71.3661 570.8533 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q [0 2.997]0 d q 1 0 0 1 74.3631 533.6455 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 71.3661 533.6455 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q 0 j 0 J q 1 0 0 1 70.8661 479.5764 cm 0 0 m 453.543 0 l S Q BT 0 0 0 1 k /T1_0 1 Tf 0.031 Tw 9 0 0 9 119.0551 730.4919 Tm [(P)45(A)45(TIENT)-9.9(S A)53(ND METHODS: a p)46(rospectiv)13(e cohor)-39.9(t study included 9 patients \(6 males\) with trans- and e)-15(xtrasphincter)-37(ic )]TJ 0.016 Tw 0 -1.111 TD [(anal f)-43(istulas. )0.5(All patients under)-31.9(w)12(ent surg)12(er)-43(y with adv)16(ancement )0.5(f)-22(lap and intraoperativ)13(e ICG-angiog)14(raph)12(y with video )]TJ 0 Tw T* (recordings.)Tj 0.103 Tw T* [(RESUL)30(T)-10(S: three types of rectal v)16(ascular netw)12(ork w)12(ere identif)-42.9(ied, distr)-36.9(ibuted by 3, 4 and 5 distal branches of the )]TJ -0.01 Tw T* [(rectal ar)-39.9(ter)-37(ies. Detailed chronometr)-42.9(y show)12(ed that the time of onset of the ar)-40(ter)-37(ial phase did no)13(t dif)-40(fer signif)-42.9(icantly)42(, )]TJ -0.022 Tw 0 -1.111 TD [(reg)12(ardless of the adv)16(ancement f)-22(lap\242)37.1(s width. How)12(ev)13(er)61(, the following chang)12(es in the v)13(enous outf)-22(low w)12(ere identif)-42.9(ied: at )]TJ -0.032 Tw 0 -1.111 TD [(full-thickness f)-21.9(lap\242)37(s width of 1/3 of the rectal circumference, a slight lengthening of the \ v)12.9(enous outf)-21.9(low w)13(as detected )]TJ 0.014 Tw T* [(\(increase of the av)13(erag)12(e time for onset of the maximum f)-22(luorescence phase to 61.5 vs the unaf)-40(fected rectum \(58.2 )]TJ -0.01 Tw T* [(sec.\). A)14(t full-thickness f)-22(lap\242)37(s width of 1/4 of the rectal circumference)]TJ /Span<>> BDC ( )Tj EMC [(\227 signif)-42.9(icant \(p)]TJ /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (0.05\) increase of the mean )Tj -0.011 Tw T* [(time for )0.5(onset of the maximal )0.5(f)-22(luorescence )0.5(phase to 77.6 sec., that )0.5(is, in 1.26 times com)16(pared to patients with f)-22(lap\242)37(s )]TJ 0.023 Tw T* (width of 1/3 of the rectal circumference.)Tj 0.159 Tw T* [(C)21(ON)22(CLUSION: ICG-angiog)14.1(raph)12(y visualize the v)13(essels of the rectum intraoperativ)13(ely)42(, and it helps to f)-43(ind op)13(timal )]TJ 0.023 Tw T* [(margins of adv)16(ancement f)-22(lap.)]TJ /T1_1 1 Tf 0.01 Tc -0.01 Tw 8 0 0 8 70.9061 595.2226 Tm [(KEYW)22(ORDS:)]TJ /T1_0 1 Tf 0 Tc 0.023 Tw 4.948 0 Td [( pararectal f)-43(istula, ICG-angiog)14.1(raph)12(y)42(, rectum\242)37.1(s angioarchitectonics)]TJ /T1_1 1 Tf 0.01 Tc 0.018 Tw -4.948 -1.909 Td [(C)19(ONFL)-33(ICTS)5( OF)5( INTE)25(REST)62(:)]TJ /T1_0 1 Tf 0 Tc 0.023 Tw 10.361 0 Td [( The authors declare no conf)-22(licts of interest)]TJ /T1_1 1 Tf 0.037 Tc -0.021 Tw -10.361 -2.617 Td [(F)3.2(O)-4.6(R)8.7( )0.5(C)-17.4(I)-15.6(T)45.4(A)37.5(T)-24.5(I)-1.3(ON:)]TJ /T1_2 1 Tf 0.023 Tc -0.012 Tw 6.423 0 Td [( )0.5(K)-20.5(h)-14(i)-15.8(t)-36.8(a)-10.2(r)-60.6(y)-24.2(a)-7.6(n)]TJ /Span<>> BDC ( )Tj EMC 4.757 0 Td [(A)-23(.)15(G)-11.6(.)-23.5(, )0.5(A)-10.3(d)-15.8(i)-8.3(z)-11.2(o)-10.3(v)]TJ /Span<>> BDC ( )Tj EMC 5.404 0 Td [(S)-9.6(.)-23.9(A)-23(.)-23.5(, )0.5(A)-11.7(l)-16.7(i)-5.9(b)-24.6(e)-16.1(k)-3.7(o)-10.3(v)]TJ /Span<>> BDC ( )Tj EMC 6.199 0 Td [(A)-23(.)-28.6(Z)-22.9(.)-23.5(, )0.5(K)-18.2(i)-7.4(s)-11.2(l)-8.3(y)-24.1(a)-11.2(k)-3.7(o)-10.3(v)]TJ /Span<>> BDC ( )Tj EMC 6.521 0 Td [(V)39.7(.)-1.9(N)-2.8(.)-23.5(, )0.5(O)-15.9(r)-19.1(e)-16.1(k)-16.8(h)-10.9(o)-10.3(v)]TJ /Span<>> BDC ( )Tj EMC 5.955 0 Td [(A)-23(.)-23.9(A)-23(.)-23.5(, )0.5(K)-20.5(h)-14(i)-15.8(t)-36.8(a)-10.2(r)-60.6(y)-24.1(a)-7.6(n)]TJ /Span<>> BDC ( )Tj EMC 6.851 0 Td [(V)39.7(.)-23.9(A)-23(.)-23.5(, )0.5(O)-12.5(p)-20.1(l)-16.7(i)-3.2(m)-8.3(a)-11.2(k)-16.8(h)]TJ /Span<>> BDC ( )Tj EMC 6.483 0 Td [(K)-27(.)-26.9(S)-9.6(.)-23.5(, )0.5(G)-14.2(o)-15.6(l)-20.9(o)-10.3(v)-51.8(i)-3.1(n)-7.9(a)]TJ /Span<>> BDC ( )Tj EMC 6.256 0 Td [(A)-23(.)-23.9(A)-23(.)23( )]TJ 0.283 Tw -54.854 -1.2 Td [(I)2.3(C)-4.7(G)-25.2(-)-13.1(a)-7.6(n)-11.9(g)-28.9(i)-6.8(o)-18.6(g)-13.5(r)-30.8(a)-8.8(p)-15.9(h)-14.9(y f)-25.2(o)-11.8(r r)-19.1(e)-19.1(c)-41.5(t)-36.8(a)-11.4(l a)-13(d)-17.7(v)-28.4(a)-7.6(n)-10(c)-9.7(e)-11.5(m)-16.6(e)-11.5(n)-17.3(t f)-47.1(l)-37.8(a)-8.8(p i)-3.2(n p)-20.1(a)-18.1(t)-46.2(i)-11(e)-11.5(n)-17.3(t)-48.9(s w)-45.7(i)-15.8(t)-26.1(h a)-7.6(n)-7.8(a)-11.4(l f)-63(i)-7.4(s)-29.2(t)-22.4(u)-8.3(l)-37.8(a)-26.6(s)-15.5(. )]TJ /T1_0 1 Tf 0.033 Tc -0.033 Tw [(K)13.9(ol)3.6(op)2.5(r)3.1(o)3.4(k)-19.2(t)2.2(ol)3.7(o)-3.3(g)-13.2(i)6.7(a)5.8(.)]TJ /T1_2 1 Tf 0.013 Tc 0.293 Tw 42.948 0 Td [( 2)-18.9(0)-13.8(2)-1.2(4;2)-20.3(3)-4(\()27.7(1)34.3(\))4.6(:)-11.4(9)-10.5(1)16.4(\226)-15.2(9)-20.8(9)13.4(.)-10.3( \()-10.9(i)-13.2(n)-10.3( R)-16.5(u)-31.9(s)-32.2(s)-25.5(.)33.2(\).)13( )]TJ 0.023 Tc -0.023 Tw -42.948 -1.2 Td [(h)-17.2(t)-49.4(t)-29.4(p)-18.7(s)-8(:)1.9(/)84.7(/)36.4(d)-11.1(o)-12.5(i.)2.7(o)-11.8(r)-16.7(g)-22.8(/)11.2(1)14(0)6.5(.)-5.6(3)7.9(3)-15.9(8)1.3(7)4.6(8/)7.9(2)-8.9(0)9.3(7)-1.9(3)-13.3(-)41.2(7)10.7(55)-8.9(6)-26.7(-)9.7(2)-8.9(0)-3.8(2)8.8(4)-28.5(-)9.7(2)-10.3(3)-13.3(-)55.1(1)26.9(-)-4.2(91)26.9(-)-4.2(9)-10.8(9)]TJ /T1_1 1 Tf 0.01 Tc -0.015 Tw 0.005 -2.617 Td [(\026\020\021\033\030)5( \020\036\017)5( \013\033\021\033\013\023\030\037\023:)]TJ /T1_0 1 Tf 0 Tc -0.01 Tw 10.511 0 Td ( \201\030\025\016\n\027 \207.\201., \224\214\221 \253\222\023\025\021\025\ \006\031\t\013\026\002 \005\n\023\022\021\025\203\026 \253\212\241\200-\240\ \031\030\025\203\025\021\026\273, \205\023.)Tj /Span<>> BDC ( )Tj EMC (\216\026\032\f\n\023\n\003\031\031\027\026, \030.)Tj /Span<>> BDC ( )Tj EMC (92 \201, \212\n\t\024\n\027-\021\026-\200\n\021\205, 344011, )Tj 0.023 Tw -10.516 -1.2 Td (\212\n\t\t\025\002; e-mail: suliman_adizov@mail.ru)Tj /T1_1 1 Tf 0.01 Tc 0.012 Tw 0.005 -1.2 Td [(ADDRESS)5( F)13(OR)5( C)19(ORRESPONDEN)23(CE:)]TJ /T1_0 1 Tf 0 Tc 0.017 Tw 14.038 0 Td [( Adizov S.A., Clinical hospital \253RZD-Medicine\273, V)33(ar)-34(folomeev)16.1(a st., 92A)12(, R)19(ostov-on-Don, 344011, R)22(ussia; e-mail: )]TJ 0 Tw -14.043 -1.2 Td (suliman_adizov@mail.ru)Tj 0 -2.792 TD (\200\026\024\026 \033\n\t\024\205\033\023\031\021\025\002)Tj /Span<>> BDC ( )Tj EMC (\227 13.11.2023)Tj /Span<>> BDC ( )Tj EMC 19.488 0 Td (\n\t\023\031 \030\n\032\026\005\n\024\013\025)Tj /Span<>> BDC ( )Tj EMC (\227 19.12.2023)Tj /Span<>> BDC ( )Tj EMC 18.78 0 Td (\032\025\021\002\024\n \013)Tj /Span<>> BDC ( )Tj EMC (\033\205\005\023\025\013\026\203\025\025)Tj /Span<>> BDC ( )Tj EMC (\227 12.02.2024)Tj ( )Tj -38.268 -1.375 Td (Received)Tj /Span<>> BDC ( )Tj EMC (\227 13.11.2023)Tj /Span<>> BDC ( )Tj EMC 19.488 0 Td (Revised)Tj /Span<>> BDC ( )Tj EMC (\227 19.12.2023)Tj /Span<>> BDC ( )Tj EMC 18.78 0 Td (Accepted for publication)Tj /Span<>> BDC ( )Tj EMC (\227 12.02.2024)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 70.936 420.3799 Tm (\023\023\034\226\034\022\031\034)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf 0 Tc 0.234 Tw 10 0 0 10 70.8661 396.0239 Tm (\200 \023\030\026\022\021\017\004\036\f\022\024\005 \022\024\035\024\023\ \030\024\022\021\024\035\024\020\017\017 \024\007\027\017\n \017)Tj /Span<>> BDC ( )Tj EMC (\027\026\017\002\024)Tj 0 Tw (-)Tj 0.082 Tw 0 -1.218 TD (\035\036\036 \004\026\f\021\024 \r\f\021\030\036\004\026\033\013\017\b\f\ \016 \023\026\021\024\035\024\020\017\004\036\f\022\017\b \f\024\f\021\024\ \016\027\017\005 )Tj 0.094 Tw T* (\016\r\035\016\033\021\f\016 \f\r\017\013\017 \023\030\016\n\024\005 \022\ \017\001\022\017, \030\026\f\023\030\024\f\021\030\026\027\036\027\027\024\ \f\021\034 )Tj 0.024 Tw T* (\022\024\021\024\030\t\b \f\024\f\021\026\r\035\016\036\021 \024\022\024\ \035\024 10\22612)Tj /Span<>> BDC ( )Tj EMC (\f\035\031\004\026\036\r \027\026)Tj /Span<>> BDC ( )Tj EMC (100)Tj /Span<>> BDC ( )Tj EMC (\021\t\f. )Tj 0.132 Tw T* (\004\036\035\024\r\036\022 \017)Tj /Span<>> BDC ( )Tj EMC (\007\024 30\22645% \r)Tj /Span<>> BDC ( )Tj EMC (\024\002\013\036\005 \f\021\030\031\022\021\031\030\036 \022\024\035\024\ \023\030\024\022)Tj 0 Tw (-)Tj 0.046 Tw T* (\021\024\035\024\020\017\004\036\f\022\017\b \026\002\024\035\036\r\026\ \027\017\005 [1,2]. \200)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\034\001\017\027\f\021\r\036 \f\035\031)Tj 0 Tw (-)Tj 0.216 Tw T* (\004\026\036\r \f\r\017\013\017 \235\024\030\n\017\030\031\033\021\f\016\ \022\026\022 \017\f\b\024\007 \024\f\021\030\024\020\024 \023\026\030\026\ )Tj 0 Tw (-)Tj 0.076 Tw T* (\023\030\024\022\021\017\021\026 \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \021\030\031\007\024\f\023\024\f\024\002\ \027\024\020\024 \r\024\030\026\f\021\026 \(\007\024 )Tj 0.081 Tw T* (50)Tj /Span<>> BDC ( )Tj EMC (\035\036\021\), \004\026\013\036)Tj /Span<>> BDC ( )Tj EMC (\227 \031)Tj /Span<>> BDC ( )Tj EMC (\n\031\032\004\017\027, \004\021\024 \024\002\031\f\035\024\r\035\017\r\026\ \036\021 \r\t\f\024)Tj 0 Tw (-)Tj 0.064 Tw T* (\022\031\033 \f\024\006\017\026\035\034\027\031\033 \027\026\004\017\n\024\ \f\021\034 \007\026\027\027\024\005 \027\024\024\035\024\020\017\004\036\ \f\022\024\005 )Tj 0 Tw T* (\036\007\017\027\017\006\t [3].)Tj 0.187 Tw T* (\223\021\024 \022\026\f\026\036\021\f\016 \b\017\030\031\030\020\017\004\ \036\f\022\024\020\024 \035\036\004\036\027\017\016, \021\024, \027\036\f\ \n\024\021\030\016 )Tj 0.227 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC (\026\022\021\017\r\027\024\036 \017\f\023\024\035\034\024\r\026\027\017\ \036 \f\024\r\030\036\n\036\027\027\t\b \f\235\017\027\022\021\036)Tj 0 Tw (-)Tj 0.271 Tw T* (\030\024\f\024\b\030\026\027\016\033\013\017\b \r\n\036\001\026\021\036\035\ \034\f\021\r \(\035\017\020\017\030\024\r\026\027\017\036 \f\r\017\013\026\ )Tj 0.365 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\n\036\032\f\235\017\027\022\021\036\030\027\024\n \023\030\024\f\021\030\ \026\027\f\021\r\036 )Tj /T1_0 1 Tf 0 Tw (\(LIFT\))Tj /T1_2 1 Tf 0.365 Tw (, \035\026\036\030\027\026\016 )Tj 0.301 Tw T* [(\024\002\035\017\021\036\030\026\006\017\016 )0.6(\f\r\017\013\026 )]TJ /T1_0 1 Tf 0 Tw 8.945 0 Td (\(FiLac\))Tj /T1_2 1 Tf 0.301 Tw [(, )0.5(\r\017\007\036\024\026\f\f\017\f\021\017\030\024\r\026\027\027\024\036 )]TJ 0.193 Tw -8.945 -1.218 Td [(\035\036\004\036\027\017\036 \023\030\016\n\024\022\017\001\036\004\027\t\ \b )0.5(\f\r\017\013\036\005 \f)]TJ /Span<>> BDC ( )Tj EMC (\017\f\023\024\035\034\024\r\026\027\017\036\n )Tj 0 Tw T* (\235\017\f\021\031\035\024\f\022\024\023\026 )Tj /T1_0 1 Tf 6.277 0 Td [(\(V)42(AAFT\))]TJ /T1_2 1 Tf 0.261 Tw ( \017)Tj /Span<>> BDC ( )Tj EMC (\007\030., \220\235\235\036\022\021\017\r\027\024\f\021\034 \021\026\022\ \017\b )Tj 0.202 Tw -6.277 -1.218 Td (\n\026\035\024\017\027\r\026\017\r\027\t\b \n\036\021\024\007\017\022 \024\ \f\021\026\036\021\f\016 \007\017\f\022\031\021\026\002\036\035\034\027\024\ \005. )Tj 0.155 Tw T* (\230\026\022, \027\026\023\030\017\n\036\030, \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\r\t\023\024\035\027\036\027\017\017 )Tj /T1_0 1 Tf 0 Tw (LIFT)Tj /T1_2 1 Tf 0.155 Tw (-\n\036\021\024\007\017\022\017 \023\030\024)Tj 0 Tw (-)Tj 0.385 Tw T* [(\006\036\027\021 \031\f\023\036\001\027\t\b \r\n\036\001\026\021\036\035\ \034\f\021\r )0.5(\f\024\f\021\026\r\035\016\036\021 40\22680%, )]TJ 0.327 Tw T* (\026)Tj /Span<>> BDC ( )Tj EMC (\030\026\r\017\021\017\036 \026\027\026\035\034\027\024\005 \017\027\022\ \024\027\021\017\027\036\027\006\017\017 \027\026\002\035\033\007\026\036\ \021\f\016 )Tj 0.108 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (1,5\2266% \f\035\031\004\026\036\r [4\2266]. \253\216\017\030\031\030\020\ \017\004\036\f\022\017\005 \031\f\023\036\b\273 \017\f)Tj 0 Tw (-)Tj T* (\023\024\035\034\024\r\026\027\017\016 )Tj /T1_0 1 Tf 5.593 0 Td (FiLaC)Tj /T1_2 1 Tf 0.079 Tw (-\021\036\b\027\017\022\017, \r)Tj /Span<>> BDC ( )Tj EMC (\021\024\n \004\017\f\035\036 \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r )Tj 0.193 Tw -5.593 -1.218 Td (\f)Tj /Span<>> BDC ( )Tj EMC (\030\036\006\017\007\017\r\026\n\017 \f\r\017\013\036\005, \f\024\f\021\026\ \r\035\016\036\021 69,7%, \026)Tj /Span<>> BDC ( )Tj EMC (\f\030\036\007\027\036)Tj 0 Tw (-)Tj 0.459 Tw T* (\r\r\036\001\036\027\027\026\016 \004\026\f\021\024\021\026 \026\027\026\ \035\034\027\024\005 \017\027\022\024\027\021\017\027\036\027\006\017\017\ )Tj /Span<>> BDC ( )Tj EMC (\227 )Tj 0.331 Tw T* (1% [7]. \215\024)Tj /Span<>> BDC ( )Tj EMC (\007\026\027\027\t\n \007\030\031\020\024\020\024 \n\036\021\026\026\027\ \026\035\017\026, \004\026\f\021\024\021\026 )Tj 0.148 Tw 23.244 34.098 Td (\220\235\235\036\022\021\017\r\027\024\020\024 \023\030\017\n\036\027\036\ \027\017\016 \007\026\027\027\024\005 \n\036\021\024\007\017\022\017 \007\ \024\f\021\017)Tj 0 Tw (-)Tj T* (\020\026\036\021 \021\024\035\034\022\024 63% [8].)Tj -0.002 Tw T* (\203\026\017\002\024\035\036\036 \017\031\004\036\027\027\t\n \023\024\007\ \b\024\007\024\n \022 \b\017\030\031\030\020\017\004\036\f\022\024\n\031\ \035\036)Tj 0 Tw (-)Tj 0.042 Tw T* (\004\036\027\017\033 \f\035\024\032\027\t\b \021\030\026\027\f- \017)Tj /Span<>> BDC ( )Tj EMC (\220\022\f\021\030\026\f\235\017\027\022\021\036\030\027\t\b \f\r\017\013\ \036\005 )Tj 0.079 Tw T* (\024\f\021\026\036\021\f\016 \017\f\f\036\004\036\027\017\036 \f\r\017\013\ \026 \023\030\016\n\024\005 \022\017\001\022\017 \f)Tj /Span<>> BDC ( )Tj EMC (\027\017\r\036\007\036)Tj 0 Tw (-)Tj 0.222 Tw T* (\027\017\036\n \023\024\035\027\024\f\035\024\005\027\024\020\024 \035\024\ \f\022\031\021\026 \023\030\016\n\024\005 \022\017\001\022\017. \230\026\ \022\026\016 )Tj 0.782 Tw T* (\n\036\021\024\007\017\022\026 \024\002\036\f\023\036\004\017\r\026\036\021\ \007\024\035\020\024\f\030\024\004\027\024\036 \026\022\030\t\021\017\036\ )Tj 0.09 Tw T* (\f\r\017\013\026)Tj /Span<>> BDC ( )Tj EMC (\227 \007\024)Tj /Span<>> BDC ( )Tj EMC (87% \f\035\031\004\026\036\r, \f\024\023\030\024\r\024\032\007\026\036\021\ \f\016 \004\026\f\021\024\021\024\005 )Tj 0.099 Tw T* [(\026\027\026\035\034\027\024\005 )0.5(\017\027\022\024\027\021\017\027\036\027\006\017\017 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC [(\023\030\036\007\036\035\026\b )0.5(7\22620,4%, \026)]TJ /Span<>> BDC ( )Tj EMC (\030\017)Tj 0 Tw (-)Tj 0.004 Tw T* (\f\022\026 \030\036\006\017\007\017\r\026)Tj /Span<>> BDC ( )Tj EMC (\227 \007\024)Tj /Span<>> BDC ( )Tj EMC (7,4% [4,5,9]. \215\030\017)Tj /Span<>> BDC ( )Tj EMC (\r\t\023\024\035\027\036\027\017\017 \023\024)Tj 0 Tw (-)Tj 0.238 Tw T* [(\007\024\002\027\t\b \024\023\036\030\026\006\017\005, )0.5(\002\036\031\f\035\024\r\027\024, \022\035\033\004\036\r\t\n\017 \220\021\ \026\023\026\n\017 )]TJ 0.084 Tw T* (\016\r\035\016\033\021\f\016 \021\036\b\027\024\035\024\020\017\016 \235\ \024\030\n\017\030\024\r\026\027\017\016 \035\024\f\022\031\021\026 \f)Tj /Span<>> BDC ( )Tj EMC (\026\007\036\022)Tj 0 Tw (-)Tj -0.039 Tw T* (\r\026\021\027\t\n \022\030\024\r\024\f\027\026\002\032\036\027\017\036\n\ \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\r\036\007\036\027\017\016 \023\035\026\f\021\017\022\017 \002\ \036 )Tj 0 Tw T* (\027\026\021\016\032\036\027\017\016 \021\022\026\027\036\005.)Tj 0.557 Tw T* (\221\024\r\030\036\n\036\027\027\t\n \n\036\021\024\007\024\n \024\006\036\ \027\022\017 \023\036\030\235\031\017\017 \021\022\026\027\036\005 )Tj 0.157 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC 0.908 0 Td [(\026\027\020\017\024\026\030\b\017\021\036\022\021\024\027\017\022\017 )0.5(\016\r\035\016\036\021\f\016 )0.5(\017\027\021\030\026\024\023\036\030\026\006\017\024\027\027\026\016 )]TJ 0.314 Tw -0.908 -1.218 Td (\235\035\031\024\030\036\f\006\036\027\021\027\026\016 \026\027\020\017\024\ \020\030\026\235\017\016 \017\027\007\024\006\017\026\027\017\027\024\n \ \036\035\036)Tj 0 Tw (-)Tj 0.124 Tw T* (\027\t\n \(\222\037\003\) \()Tj /T1_0 1 Tf (Indocyanine Green\))Tj /Span<>> BDC ( )Tj EMC (\227 )Tj /T1_2 1 Tf 0 Tw (ICG-\026\027\020\017\024\020\030\026\235\017\016. )Tj 0.356 Tw T* [(\222\037\003 \023\030\036\007\f\021\026\r\035\016\036\021 )0.5(\f\024\002\024\005 \021\030\017\022\026\030\002\024\006\017\026\027\017\027\ \024\r\024\036 )0.5(\f\024)]TJ 0 Tw (-)Tj 0.316 Tw T* (\036\007\017\027\036\027\017\036, \030\026\f\021\r\024\030\017\n\024\036\ \r)Tj /Span<>> BDC ( )Tj EMC (\r\024\007\036, \002\t\f\021\030\024 \017)Tj /Span<>> BDC ( )Tj EMC (\026\022\021\017\r\027\024 )Tj 0.175 Tw T* [(\f\r\016\t\r\026\033\013\036\036\f\016 )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC [(\002\036\035\022\026\n\017 )0.5(\023\035\026\n\t \017)]TJ /Span<>> BDC ( )Tj EMC 16.065 0 Td [(\017\n\036\033\013\036\036 )0.5(\002\035\026)]TJ 0 Tw (-)Tj 0.238 Tw -16.065 -1.218 Td (\020\024\023\030\017\016\021\027\t\005 \023\030\024\235\017\035\034 \002\ \036\024\023\026\f\027\024\f\021\017, \004\021\024 \007\036\035\026\036\ \021 \036\020\024 )Tj 0.305 Tw T* (\023\036\030\f\023\036\022\021\017\r\027\t\n \007\035\016 \017\f\023\024\ \035\034\024\r\026\027\017\016 \r)Tj /Span<>> BDC ( )Tj EMC (\026\027\020\017\024\020\030\026\235\017\017 )Tj 0.447 Tw T* ([10\22612]. \212\026\027\027\t\005 \235\035\033\024\030\036\f\006\036\027\ \021\027\t\005 \023\030\036\023\026\030\026\021 \031\032\036 )Tj 0.255 Tw T* (\031\f\023\036\001\027\024 \017\f\023\024\035\034\031\036\021\f\016 \r)Tj /Span<>> BDC ( )Tj EMC (\022\024\035\024\030\036\022\021\026\035\034\027\024\005 \b\017\030\031\030\ \020\017\017, )Tj 0.251 Tw T* [(\b\017\030\031\030\020\017\017 \r\036\030\b\027\017\b )0.5(\024\021\007\036\035\024\r \240\025\230, \021\030\026\027\f\023\035\026\027\ \021\024\035\024\020\017\017, )]TJ -0.062 Tw T* (\024\027\022\024\035\024\020\017\017, \017)Tj /Span<>> BDC ( )Tj EMC (\030\026\f\f\n\026\021\030\017\r\026\036\021\f\016 \022\026\022 \024\f\027\ \024\r\027\024\005 \024\030\017\036\027\021\017\030 )Tj 0.239 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\024\002\036\f\023\036\004\036\027\017\017 \002\036\024\023\026\f\027\024\ \f\021\017 \007\026\027\027\t\b \r\n\036\001\026\021\036\035\034\f\021\r\ )Tj 0.17 Tw T* ([13,14]. \210\007\027\026\022\024 \027\026\031\004\027\t\036 \030\026\002\ \024\021\t \023\024)Tj /Span<>> BDC ( )Tj EMC (\017\f\023\024\035\034\024\r\026\027\017\033 )Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 0 Tw 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\033\030\031\030\213\b)-20.9(\035\231\213\233\t \021\032)50(\b)42(\032\231\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj -51.938 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 23, \023\0221)69(, 202)69(4)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 23, \023\0221)69(, 202)69(4)]TJ /T1_5 1 Tf 25 0 0 25 28.115 56.0378 Tm (92)Tj ET endstream endobj 1599 0 obj [1622 0 R] endobj 1600 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(IC)31(G-\013\001\202\220\025\202\002\013\225\220\205 \r\022\025\227\016\001\n\016\ \n\013\017\016\006)-10(\026\r\013 \225\025\002\024\220\002\025\r\013\001\220\205 )]TJ 0 -1 TD [(\221\025\007\001\025\006)-9.9(\007\025\203\001\025\202)10(\025 \221\002\205\024\025\n\220\016\017\001\025\202)10(\025 \007\025\006\n\215)-19.9(\026)11(\013 \221\002\220\022\025\221\016\002\013\026\220\r\001\025\024 )]TJ T* [(\007\016\017\016\001\220\220 \006)-10(\007\025\217\001\020\207 \221\002\205\024\025\n\220\016\017\001\020\207\ \006\r\220\224\016\203)]TJ 31.181 2 Td [(IC)31(G-angiogr)21.1(aph)31(y for r)31(ectal adv)10(ancement flap in patients with anal f)-21(istulas)]TJ ET 0 0 0 1 K 1 j 1 J [0 2.997]0 d /GS1 gs q 1 0 0 1 46.0167 290.0103 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 43.0197 290.0103 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q [0 2.997]0 d q 1 0 0 1 46.0167 252.8025 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 43.0197 252.8025 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q BT 0 0 0 1 k /T1_1 1 Tf 10 0 0 10 42.5197 724.8299 Tm (https://doi.org/10.33878/2073-7556-2024-23-1-91-99)Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 0.023 Tw 19 0 0 19 63.5603 695.3259 Tm [(IC)31(G-\013\001\202\220\025\202\002\013\225\220\205 \r\022)-23.3(\025\227\016\001\n\016 \n\013\017\016\006)-10(\026\r\013 \225\025\002\024\220\002\025\r\013\001\220\205 )]TJ 2.286 -1.105 Td [(\221\025\007\001\025\006)-9.9(\007\025\203\001\025\202)10(\025 \221\002\205\024\025\n\220\016\017\001\025\202)10.1(\025 \007\025\006\n\215)-20(\026)11(\013 )]TJ -2.336 -1.105 Td [(\221\002\220\022)-23.3(\025\221\016\002\013\026\220\r\001\025\024 \007\016\017\016\001\220\220 \ \006)-10(\007\025\217\001\020\207 \221\002\205\024\025\n\220\016\017\001\020\207\ )]TJ 0 Tw 9.338 -1.105 Td (\006\r\220\224\016\203)Tj 0 0 0 1 k /GS1 gs 14 0 0 14 42.5197 607.822 Tm [(\204\220\026)11(\013\002\216\205\001\022)-23.2(\b)-31(.\031)72(.)]TJ -0.069 Tc 0.069 Tw 8.162 0 0 8.162 120.6429 612.484 Tm [(1,)-69(2)]TJ 0 Tc 0.023 Tw 14 0 0 14 131.9635 607.822 Tm [(, \b)-21(\201\220\222\025\r\022)-23.2(\021.\b)-31(.)]TJ 0 Tw 8.162 0 0 8.162 212.1623 612.484 Tm (1)Tj 0.023 Tw 14 0 0 14 216.7983 607.822 Tm [(, \b)-21(\007\220\f\016\n)10.1(\025\r\022)-23.3(\b)-31(.\211.)]TJ -0.069 Tc 0.069 Tw 8.162 0 0 8.162 310.1289 612.484 Tm [(1,)-69(2)]TJ 0 Tc 0.023 Tw 14 0 0 14 321.4495 607.822 Tm [(, \037)20(\220\006)-10(\007\205\n)10(\025\r\022)-23.2(\004.\213.)]TJ 0 Tw 8.162 0 0 8.162 409.7965 612.484 Tm (1)Tj 14 0 0 14 414.4325 607.822 Tm (, )Tj -26.565 -1.143 Td [(\036\002\016)21(\207\025\r\022)-23.2(\b)-31(.\b)-31(.)]TJ -0.069 Tc 0.069 Tw 8.162 0 0 8.162 117.8846 596.484 Tm [(1,)-69(2)]TJ 0 Tc 0.023 Tw 14 0 0 14 129.2052 591.822 Tm [(, \204\220\026)11(\013\002\216\205\001\022)-23.2(\004.\b)-31(.)]TJ 0 Tw 8.162 0 0 8.162 217.7761 596.484 Tm (2)Tj 0.023 Tw 14 0 0 14 222.4121 591.822 Tm [(, \036\221\007\220\024\013\207\022)-23.2(\037.\021.)]TJ 0 Tw 8.162 0 0 8.162 312.131 596.484 Tm (2)Tj 0.023 Tw 14 0 0 14 316.7669 591.822 Tm [(, \031)80(\025\007\025\r\220\001\013\022)-23.2(\b)-31(.\b)-31(.)]TJ -0.069 Tc 0.069 Tw 8.162 0 0 8.162 408.6697 596.484 Tm [(1,)-69(2)]TJ 0 Tc 0 Tw 5.83 0 0 5.83 42.5197 577.4827 Tm (1)Tj 0.023 Tw 10 0 0 10 45.8311 574.1527 Tm [(\003\240)31(\211 \253\037\007\220\001\220\017\016\006\n\013\205 \f\025\007\216\001\220\ \227\013 \253\033\223\255)-73(-\005\016\201\220\227\220\001\013\273 \(\215\007.\022)-23.3(\004\013\002\225\025\007\025\024\016\016\r\013, \201.\022)-23.3(9)35(2 \b)-52(, \202)62(.\022)-23.3(\033\025\006)-10(\026)11(\025\r-\001\013)-84(-)-51.9(\255\025\001\215)31(, 3)58(440)87(1)212(1)69(, )]TJ 0 Tw -0.331 -1.2 Td (\033\025\006\006\220\205\))Tj ( )Tj 5.83 0 0 5.83 42.5197 553.4827 Tm (2)Tj 0.023 Tw 10 0 0 10 45.8311 550.1527 Tm [(\210\031\214)42(\240)21(\036)20(\240 \004\036 \253\033\025\006)-10(\026)11(\025\r\006\n\220\203 \202)10.1(\025\006\215\201\013\002\006)-10(\026\r\016\001\001\020\203 \024\016\201\220\227\220\001\006\n\220\203 \215\ \001\220\r\016\002\006\220\026)11(\016\026\273 \005\220\001\222\201\002\013\r\013 \033\025\006\006\220\220\ )]TJ -0.331 -1.2 Td [(\(\213\013\207\220\017\016\r\013\001\006\n\220\203\022)-23.2(\221\016\002)-31(., \201.\022)-23.3(2)47(9, \202)62(.\022)-23.3(\033\025\006)-10(\026)11(\025\r-\001\013)-83.9(-)-52(\255\025\001\215)31(, 3)58(44022, \033\025\006\006\220\205\))]TJ /T1_1 1 Tf 0.005 Tw 9 0 0 9 90.7087 519.6488 Tm (\037\036\035\034: \n\203\031\021\013\026 \203\031\023\031\t\n\n\005\032\026\ \016\021\n\t\024\025 \025\t\033\n\023\022\016\n\027\026\021\025\002 ICG-\ \026\021\202\025\n\202\032\026\f\025\025 \030\023\002 \f\n\032\003\025\032\ \n\027\026\021\025\002 \033\n\023\021\n\t\023\n\017\021\n\202\n \023\n\t\ \013\205\024\026 )Tj 0.023 Tw 0 -1.111 TD (\033\032\025)Tj /Span<>> BDC ( )Tj EMC (\023\031\006\031\021\025\025 \t\023\n\204\021\020\004 \033\032\002\003\n\ \013\025\001\031\006\021\020\004 \t\027\025\211\031\017.)Tj 0.126 Tw T* [(\201\037\215\036\217\220\235 )0.5(\215)]TJ /Span<>> BDC ( )Tj EMC [(\240\036\220\255\200\235: \005\020\023\n )0.5(\027\020\033\n\023\021\031\021\n \033\032\n\t\033\031\013\024\025\027\021\ \n\031 )0.5(\013\n\202\n\032\024\021\n\031 )0.5(\025\t\t\023\031\030\n\027\026\021\025\031, \n\t\021\n\027\026\021\021\n\ \031 \021\026)]TJ /Span<>> BDC ( )Tj EMC (\025\016\205\006\031\021\025\025 )Tj -0.01 Tw T* (\025\021\024\032\026\n\033\031\032\026\203\025\n\021\021\n\017 ICG-\026\021\ \202\025\n\202\032\026\f\025\025 \025)Tj /Span<>> BDC ( )Tj EMC (\031\031 \027\025\030\031\n\016\026\033\025\t\031\017 \033\032\025)Tj /Span<>> BDC ( )Tj EMC (\023\031\006\031\021\025\025 \t\023\n\204\021\020\004 \033\032\002\003\n\ \013\025\001\031\006\021\020\004 \t\027\025\211\031\017 \t)Tj /Span<>> BDC ( )Tj EMC (\021\025\016)Tj 0 Tw (-)Tj 0.109 Tw T* (\027\031\030\031\021\025\031\003 \033\n\023\021\n\t\023\n\017\021\n\202\n\ \023\n\t\013\205\024\026 \033\032\002\003\n\017 \013\025\001\013\025. \216\ )Tj /Span<>> BDC ( )Tj EMC (\025\t\t\023\031\030\n\027\026\021\025\031 \005\020\023\025 \027\013\023\ \007\006\031\021\020 9 \033\026\203\025\031\021\024\n\027: 6)Tj /Span<>> BDC ( )Tj EMC (\(66,7%\) )Tj 0.023 Tw T* (\003\205\204\006\025\021 \025)Tj /Span<>> BDC ( )Tj EMC (3)Tj /Span<>> BDC ( )Tj EMC (\(33,3%\) \204\031\021\211\025\021\020.)Tj 0.157 Tw T* [(\212\036\221\214\035\034\220\201\220\235: \005\023\026\202\n\030\026\032\ \002 \033\032\n\027\031\030\031\021\025\007 \025\021\024\032\026\n\033\031\ \032\026\203\025\n\021\021\n\017 )0.5(ICG-\026\021\202\025\n\202\032\026\f\025\025 \005\020\023\n \027\020\002\ \027\023\031\021\n 3 \024\025\033\026 \026\021\202\025\n)]TJ 0 Tw (-)Tj 0.109 Tw T* (\026\032\004\025\024\031\013\024\n\021\025\013\025 \033\032\002\003\n\017\ \013\025\001\013\025: \t)Tj /Span<>> BDC ( )Tj EMC (3-\003\002, 4-\003\002 \025)Tj /Span<>> BDC ( )Tj EMC (5-\007 \030\025\t\024\026\023\022\021\020\003\025 \027\031\024\027\002\003\ \025 \033\032\002\003\n\013\025\001\031\006\021\020\004 \026\032\024\031\ \032\025\017, \t\n\n\024)Tj 0 Tw (-)Tj 0.036 Tw 0 -1.111 TD (\027\031\024\t\024\027\031\021\021\n. \n\t\023\031\030\205\007\211\026\002\ \030\031\024\026\023\022\021\026\002 \004\032\n\021\n\003\031\024\032\025\ \002 \027\025\030\031\n\016\026\033\025\t\031\017 \033\n\013\026\016\026\ \023\026, \006\024\n \027\032\031\003\002 \021\026\t\024\205\033\023\031\ \021\025\002 \026\032\024\031)Tj 0 Tw (-)Tj 0.114 Tw 0 -1.111 TD (\032\025\026\023\022\021\n\017 \f\026\016\020 \021\031 \025\003\031\023\n\ \016\021\026\006\025\003\n\017 \032\026\016\021\025\203\020 \021\031\016\ \026\027\025\t\025\003\n \n\024 \001\025\032\025\021\020 \f\n\032\003\025\ \032\205\031\003\n\202\n \023\n\t\013\205\024\026. \255\030\021\026\013\n\ \005\020\023\025 )Tj 0.008 Tw T* [(\027\020\002\027\023\031\021\020 )0.6(\t\023\031\030\205\007\211\025\031 )0.5(\025\016\003\031\021\031\021\025\002 )0.6(\027)]TJ /Span<>> BDC ( )Tj EMC 14.441 0 Td [(\027\031\021\n\016\021\n\003 )0.6(\n\024\024\n\013\031: )0.5(\033\032\025)]TJ /Span<>> BDC ( )Tj EMC 9.647 0 Td [(\001\025\032\025\021\031 )0.5(\033\n\023\021\n\t\023\n\017\021\n\202\n )0.5(\023\n\t\013\205\024\026 )0.5(\027)]TJ /Span<>> BDC ( )Tj EMC 14.171 0 Td [(1/3 )0.5(\n\013\032\205\204\021\n\t\024\025 )]TJ 0.221 Tw -38.259 -1.111 Td (\033\032\002\003\n\017 \013\025\001\013\025 \021\026\005\023\007\030\026\ \023\n\t\022 \021\031\016\021\026\006\025\024\031\023\022\021\n\031 \205\ \030\023\025\021\031\021\025\031 \027\031\021\n\016\021\n\202\n \n\024\024\ \n\013\026, \027\020\032\026\204\026\007\211\031\031\t\002 \027)Tj /Span<>> BDC ( )Tj EMC (\205\030\023\025\021\031\021\025\025 )Tj 0.025 Tw T* (\t\032\031\030\021\031\202\n \027\032\031\003\031\021\025 \021\026\t\024\ \205\033\023\031\021\025\002 \f\026\016\020 \003\026\013\t\025\003\026\023\ \022\021\n\017 \f\023\007\n\032\031\t\203\031\021\203\025\025 \030\n)Tj /Span<>> BDC ( )Tj EMC (61,5 \t\031\013. \033\n)Tj /Span<>> BDC ( )Tj EMC (\t\032\026\027\021\031\021\025\007 \t)Tj /Span<>> BDC ( )Tj EMC (\025\021\024\026\013\024\021\n\017 )Tj -0.026 Tw T* (\013\025\001\013\n\017 \(58,2 \t\031\013.\), \026)Tj /Span<>> BDC ( )Tj EMC (\033\032\025 \001\025\032\025\021\031 \023\n\t\013\205\024\026 \027)Tj /Span<>> BDC ( )Tj EMC (1/4 \n\013\032\205\204\021\n\t\024\025)Tj /Span<>> BDC ( )Tj EMC (\227 \027)Tj /Span<>> BDC ( )Tj EMC (\030\n\t\024\n\027\031\032\021\n\003 \(p)Tj /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (0,05\) \205\030\023\025\021\031\021\025\025 \t\032\031\030\021\031\202\n\ )Tj 0.11 Tw T* (\027\032\031\003\031\021\025 \021\026\t\024\205\033\023\031\021\025\002 \ \f\026\016\020 \003\026\013\t\025\003\026\023\022\021\n\017 \f\023\205\n\ \032\031\t\203\031\021\203\025\025 \030\n)Tj /Span<>> BDC ( )Tj EMC (77,6 \t\031\013., \024\n \031\t\024\022 \027)Tj /Span<>> BDC ( )Tj EMC (1,26 \032\026\016\026 \033\n)Tj /Span<>> BDC ( )Tj EMC (\t\032\026\027\021\031\021\025\007 )Tj 0.023 Tw T* (\t)Tj /Span<>> BDC ( )Tj EMC (\024\026\013\n\027\020\003 \033\n\013\026\016\026\024\031\023\031\003 \205\ )Tj /Span<>> BDC ( )Tj EMC (\033\026\203\025\031\021\024\n\027 \t)Tj /Span<>> BDC ( )Tj EMC (\001\025\032\025\021\n\017 \f\n\032\003\025\032\205\031\003\n\202\n \023\ \n\t\013\205\024\026 \027)Tj /Span<>> BDC ( )Tj EMC (1/3 \n\013\032\205\204\021\n\t\024\025 \033\032\002\003\n\017 \013\025\001\ \013\025.)Tj 0.195 Tw T* (\221\201\222\035\223\224\036\217\215\036: \033\032\025)Tj /Span<>> BDC ( )Tj EMC (\023\031\006\031\021\025\025 \t\023\n\204\021\020\004 \033\032\002\003\n\ \013\025\001\031\006\021\020\004 \t\027\025\211\031\017 \t)Tj /Span<>> BDC ( )Tj EMC (\021\025\016\027\031\030\031\021\025\031\003 \033\n\023\021\n\t\023\n\017\ \021\n\202\n \023\n\t\013\205\024\026 ICG-)Tj -0.034 Tw 0 -1.111 TD (\026\021\202\025\n\202\032\026\f\025\002 \033\n\016\027\n\023\002\031\024\ \027)Tj /Span<>> BDC ( )Tj EMC (\025\021\024\032\026\n\033\031\032\026\203\025\n\021\021\020\004 \205\t\023\ \n\027\025\002\004 \027\025\016\205\026\023\025\016\025\032\n\027\026\024\ \022 \t\n\t\205\030\020 \033\032\002\003\n\017 \013\025\001\013\025, \006\ \024\n \t\033\n\t\n\005)Tj 0 Tw (-)Tj -0.022 Tw 0 -1.111 TD (\t\024\027\205\031\024 \027\020\005\n\032\205 \202\032\026\021\025\203 \f\ \n\032\003\025\032\n\027\026\021\025\002 \033\n\023\021\n\t\023\n\017\021\ \n\202\n \023\n\t\013\205\024\026, \026)Tj /Span<>> BDC ( )Tj EMC (\024\026\013\204\031 \033\n\016\027\n\023\002\031\024 \n\203\031\021\025\ \024\022 \013\032\n\027\n\t\021\026\005\204\031\021\025\031 )Tj 0 Tw T* (\023\n\t\013\205\024\026.)Tj /T1_2 1 Tf 0.01 Tc 0.018 Tw 8 0 0 8 42.5596 314.3796 Tm [(\037\036\035\034\033\032\031\033)5( \030\036\027\032\026:)]TJ /T1_1 1 Tf 0 Tc 0.023 Tw 8.493 0 Td ( \033\032\002\003\n\013\025\001\031\006\021\020\017 \t\027\025\211, ICG-\ \026\021\202\025\n\202\032\026\f\025\002, \026\021\202\025\n\026\032\004\ \025\024\031\013\024\n\021\025\013\026 \033\032\002\003\n\017 \013\025\001\ \013\025)Tj /T1_2 1 Tf 0.01 Tc 0.018 Tw -8.493 -1.909 Td [(\037\027\025\024\036\023\037\022)5( \023\025\022\033\021\033\030\027\032:)]TJ /T1_1 1 Tf 0 Tc 0.023 Tw 10.401 0 Td ( \026\027\024\n\032\020 \016\026\002\027\023\002\007\024 \n\005 \n\024\t\ \205\024\t\024\027\025\025 \013\n\021\f\023\025\013\024\026 \025\021\024\ \031\032\031\t\n\027)Tj /T1_2 1 Tf 0.033 Tc 0.146 Tw -10.401 -2.617 Td [(\020\036\017)4.7( \016\023\022\023\021\027\032\026\025\023\017:)]TJ /T1_3 1 Tf 0.023 Tc 0.151 Tw 9.318 0 Td ( \216\017\021\026\030\034\016\027)Tj /Span<>> BDC ( )Tj EMC (\202.\206., \202\007\017\024\r)Tj /Span<>> BDC ( )Tj EMC (\221.\202., \202\035\017\002\036\022\024\r)Tj /Span<>> BDC ( )Tj EMC (\202.\003., \025\017\f\035\016\022\024\r)Tj /Span<>> BDC ( )Tj EMC (\200.\203., \210\030\036\b\024\r)Tj /Span<>> BDC ( )Tj EMC (\202.\202., \216\017\021\026\030\034\016\027)Tj /Span<>> BDC ( )Tj EMC (\200.\202., \210\023\035\017\n\026\b)Tj /Span<>> BDC ( )Tj EMC (\025.\221. ICG-)Tj 0.033 Tw -9.323 -1.2 Td (\026\027\020\017\024\020\030\026\235\017\016 \r)Tj /Span<>> BDC ( )Tj EMC (\024\006\036\027\022\036 \022\026\004\036\f\021\r\026 \235\024\030\n\017\ \030\024\r\026\027\017\016 \023\024\035\027\024\f\035\024\005\027\024\020\ \024 \023\030\016\n\024\022\017\001\036\004\027\024\020\024 \035\024\f\022\ \031\021\026 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\024\023\036\030\026\021\017\r\027\024\n \035\036\004\036\027\017\017 \f\ \035\024\032\027\t\b \023\030\016)Tj 0 Tc 0 Tw (-)Tj 0.023 Tc 0.024 Tw 0 -1.2 TD (\n\024\022\017\001\036\004\027\t\b \f\r\017\013\036\005. )Tj /T1_1 1 Tf -0.023 Tw (\222\n\023\n\033\032\n\013\024\n\023\n\202\025\002.)Tj /T1_3 1 Tf 0.024 Tw ( 2024; \021.)Tj /Span<>> BDC ( )Tj EMC (23, \225)Tj /Span<>> BDC ( )Tj EMC (1, \f.)Tj /Span<>> BDC ( )Tj EMC [(91\22699. )0.5(https://doi.org/10.33878/2073-7556-2024-23-1-91-99)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 0 Tc 0.023 Tw 18 0 0 18 120.8123 226.6332 Tm [(IC)31(G-angiogr)21.1(aph)31(y for r)31(ectal adv)10(ancement )]TJ 1.875 -1.167 Td [(flap in patients with anal f)-21(istulas)]TJ 0 0 0 1 k /GS1 gs 0 Tw 14 0 0 14 42.5197 181.1293 Tm [(Alek)11(sandr\022)-23.2(G.\022)-23.3(Khitar)-30.9(y)21(an)]TJ -0.069 Tc 0.069 Tw 8.162 0 0 8.162 174.7553 185.7913 Tm [(1,)-69(2)]TJ 0 Tc 0.023 Tw 14 0 0 14 186.076 181.1293 Tm [(, Suleiman\022)-23.2(A)-31(.\022)-23.3(Adiz)10.1(ov)]TJ 0 Tw 8.162 0 0 8.162 305.4502 185.7913 Tm (1)Tj 0.023 Tw 14 0 0 14 310.0862 181.1293 Tm [(, Alber)-19.9(t\022)-23.3(Z.\022)-23.3(Alibek)11.1(ov)]TJ -0.069 Tc 0.069 Tw 8.162 0 0 8.162 420.6823 185.7913 Tm [(1,)-69(2)]TJ 0 Tc 0 Tw 14 0 0 14 432.0029 181.1293 Tm (, )Tj -27.82 -1.143 Td [(V)31(asiliy\022)-23.2(N.\022)-23.3(Kisly)21(ak)11.1(ov)]TJ 8.162 0 0 8.162 153.2238 169.7913 Tm (1)Tj 0.023 Tw 14 0 0 14 157.8598 165.1293 Tm [(, Alek)11(sey\022)-23.2(A)-31(.\022)-23.3(Or)31(ekh)11(ov)]TJ -0.069 Tc 0.069 Tw 8.162 0 0 8.162 278.4103 169.7913 Tm [(1,)-69(2)]TJ 0 Tc 0.023 Tw 14 0 0 14 289.7309 165.1293 Tm [(, V)30(er)21(a\022)-23.2(A)-31(.\022)-23.3(Khitar)-31(y)21(an)]TJ 0 Tw 8.162 0 0 8.162 399.2911 169.7913 Tm (2)Tj 14 0 0 14 403.9271 165.1293 Tm (, )Tj -25.815 -1.143 Td [(K)20(seniy)21(a\022)-23.2(S.\022)-23.3(Oplimakh)]TJ 8.162 0 0 8.162 158.8661 153.7913 Tm (2)Tj 0.023 Tw 14 0 0 14 163.502 149.1293 Tm [(, Anastasia\022)-23.2(A)-31(.\022)-23.3(Golovina)]TJ -0.069 Tc 0.069 Tw 8.162 0 0 8.162 298.7096 153.7913 Tm [(1,)-69(2)]TJ 0 Tc 0 Tw 5.83 0 0 5.83 42.5197 134.79 Tm (1)Tj 0.023 Tw 10 0 0 10 45.8311 131.46 Tm [(Priv)10(ate h)10.9(ealthcar)31.1(e institution \253Clinical Hospital \253Russian Railw)20.1(ay)-21(-Medicine\273 \(V)31(ar)-10(folomee)11(v)10(a\022)-23.3(st., 9)35(2A)-31(, Rostov)-51.9(-on-)]TJ -0.331 -1.2 Td [(Don, 3)58(440)87(1)212(1)69(, Russia\))]TJ 0 Tw ( )Tj 5.83 0 0 5.83 42.5197 110.7901 Tm (2)Tj 0.023 Tw 10 0 0 10 45.8311 107.4601 Tm [(Rostov State Medical Univ)12.1(er)20(sit)-20(y \(Nakhich)11.1(e)11(v)10(ansky per)52(., 2)47(9, Rostov)-52(-on-Don, 3)58(44022, Russia\))]TJ /T1_1 1 Tf 9 0 0 9 90.7087 88.9561 Tm [(AIM: to ev)16(aluate ICG-angiog)14.1(raph)12(y for the f)-43(istula adv)16(ancement f)-22(lap.)]TJ ET 1 0.68 0 0.12 k /GS0 gs q 1 0 0 1 42.5197 528.1533 cm 0 0 m 0 0 l 0 -11.339 l 42.52 -11.339 l 42.52 0 l h f Q BT 0 0 0 0 k /T1_2 1 Tf 0 Tw 9 0 0 9 47.6607 519.226 Tm (\021\033\r\035\f\033)Tj ET 1 0.68 0 0.12 k q 1 0 0 1 42.5197 97.4604 cm 0 0 m 0 0 l 0 -11.339 l 42.52 -11.339 l 42.52 0 l h f Q BT 0 0 0 0 k /T1_2 1 Tf 9 0 0 9 45.2263 88.5332 Tm (ABSTRACT)Tj 1 0.68 0 0.12 k /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\033\030\031\030\213\b)-20.9(\035\231\213\233\t \021\032)50(\b)42(\032\231\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj /T1_4 1 Tf 25 0 0 25 512.002 56.0378 Tm (91)Tj ET q 0 g 0 G 0 j 0 J /Fm1 Do Q 0 0 0 0 k 368.504 725.67 59.155 11.338 re f /PlacedPDF /MC0 BDC q 369.135 736.808 m 368.896 736.808 368.703 736.616 368.703 736.376 c 368.703 736.376 l 368.703 726.285 l 368.703 726.045 368.896 725.853 369.135 725.853 c 369.135 725.853 l 427.035 725.853 l 427.273 725.853 427.469 726.045 427.469 726.285 c 427.469 726.285 l 427.469 736.376 l 427.469 736.616 427.273 736.808 427.035 736.808 c 427.035 736.808 l h W n q 0 g -0.0000005 -10.9560913 -10.9560913 0.0000005 398.0855785 736.8086309 cm BX /Sh0 sh EX Q Q q 368.504 725.67 59.155 11.337 re W n 0 0 0 0.84 k q 1 0 0 1 385.2169 732.4249 cm 0 0 m -0.025 0.1 -0.063 0.196 -0.112 0.287 c -0.157 0.374 -0.218 0.451 -0.292 0.515 c -0.37 0.582 -0.46 0.632 -0.558 0.664 c -0.669 0.701 -0.786 0.719 -0.903 0.717 c -1.076 0.722 -1.247 0.681 -1.4 0.6 c -1.536 0.526 -1.652 0.42 -1.74 0.292 c -1.83 0.158 -1.895 0.008 -1.934 -0.149 c -2.018 -0.48 -2.018 -0.827 -1.934 -1.158 c -1.896 -1.316 -1.83 -1.466 -1.74 -1.602 c -1.653 -1.731 -1.536 -1.837 -1.4 -1.912 c -1.247 -1.993 -1.076 -2.033 -0.903 -2.029 c -0.774 -2.032 -0.647 -2.006 -0.528 -1.955 c -0.427 -1.906 -0.337 -1.837 -0.263 -1.753 c -0.185 -1.665 -0.124 -1.563 -0.082 -1.453 c -0.034 -1.338 0 -1.218 0.019 -1.094 c 0.635 -1.094 l 0.624 -1.297 0.578 -1.497 0.497 -1.684 c 0.421 -1.857 0.312 -2.015 0.175 -2.146 c 0.039 -2.277 -0.123 -2.379 -0.3 -2.446 c -0.492 -2.519 -0.695 -2.555 -0.9 -2.552 c -1.15 -2.557 -1.397 -2.506 -1.625 -2.404 c -1.829 -2.307 -2.01 -2.169 -2.157 -1.997 c -2.308 -1.821 -2.423 -1.617 -2.497 -1.397 c -2.655 -0.924 -2.655 -0.412 -2.497 0.061 c -2.423 0.281 -2.307 0.485 -2.157 0.661 c -2.01 0.833 -1.829 0.973 -1.625 1.07 c -1.398 1.174 -1.15 1.226 -0.9 1.222 c -0.707 1.223 -0.515 1.196 -0.329 1.14 c -0.159 1.088 0.001 1.006 0.144 0.898 c 0.278 0.793 0.39 0.662 0.473 0.513 c 0.562 0.349 0.615 0.167 0.629 -0.019 c 0 -0.019 l 0 0 l f Q q 1 0 0 1 386.3458 733.5723 cm 0 0 m 0.584 0 l 0.584 -1.328 l 0.662 -1.204 0.771 -1.103 0.9 -1.033 c 1.046 -0.951 1.213 -0.91 1.381 -0.914 c 1.627 -0.9 1.869 -0.979 2.058 -1.137 c 2.234 -1.312 2.325 -1.556 2.305 -1.803 c 2.305 -3.596 l 1.716 -3.596 l 1.716 -1.976 l 1.724 -1.817 1.678 -1.66 1.585 -1.53 c 1.486 -1.43 1.347 -1.379 1.206 -1.392 c 1.114 -1.39 1.024 -1.408 0.94 -1.445 c 0.865 -1.479 0.798 -1.529 0.744 -1.591 c 0.687 -1.656 0.645 -1.73 0.616 -1.812 c 0.586 -1.896 0.571 -1.986 0.571 -2.077 c 0.571 -3.615 l 0 -3.615 l 0 0 l f Q q 1 0 0 1 389.692 731.1235 cm 0 0 m 0 -0.099 0.014 -0.198 0.043 -0.292 c 0.069 -0.382 0.112 -0.466 0.17 -0.54 c 0.229 -0.611 0.304 -0.669 0.388 -0.709 c 0.486 -0.754 0.594 -0.776 0.702 -0.773 c 0.845 -0.78 0.987 -0.742 1.108 -0.664 c 1.217 -0.582 1.296 -0.468 1.336 -0.337 c 1.881 -0.337 l 1.827 -0.603 1.675 -0.838 1.456 -0.996 c 1.35 -1.073 1.231 -1.131 1.105 -1.169 c 0.971 -1.208 0.831 -1.229 0.691 -1.227 c 0.509 -1.227 0.328 -1.191 0.16 -1.121 c 0.007 -1.063 -0.13 -0.972 -0.244 -0.855 c -0.356 -0.73 -0.44 -0.583 -0.491 -0.422 c -0.548 -0.243 -0.576 -0.056 -0.574 0.133 c -0.575 0.313 -0.545 0.493 -0.486 0.664 c -0.426 0.826 -0.335 0.974 -0.22 1.102 c 0.004 1.375 0.338 1.534 0.691 1.535 c 0.883 1.539 1.072 1.495 1.243 1.408 c 1.402 1.326 1.541 1.209 1.649 1.067 c 1.759 0.922 1.838 0.757 1.883 0.582 c 1.932 0.396 1.945 0.203 1.92 0.013 c 0 0.013 l 0 0 l 1.342 0.377 m 1.335 0.468 1.315 0.557 1.283 0.643 c 1.253 0.724 1.209 0.798 1.153 0.863 c 1.097 0.922 1.03 0.97 0.957 1.004 c 0.874 1.043 0.783 1.063 0.691 1.062 c 0.6 1.062 0.509 1.044 0.425 1.009 c 0.345 0.976 0.273 0.926 0.213 0.863 c 0.153 0.799 0.105 0.724 0.072 0.643 c 0.037 0.559 0.017 0.468 0.014 0.377 c 1.355 0.377 l h f Q q 1 0 0 1 393.8116 731.7051 cm 0 0 m -0.012 0.144 -0.082 0.276 -0.194 0.366 c -0.31 0.452 -0.451 0.495 -0.595 0.489 c -0.675 0.488 -0.755 0.476 -0.831 0.452 c -0.918 0.424 -0.998 0.375 -1.062 0.311 c -1.142 0.229 -1.202 0.131 -1.24 0.024 c -1.29 -0.132 -1.312 -0.296 -1.304 -0.459 c -1.304 -0.569 -1.292 -0.677 -1.267 -0.784 c -1.244 -0.885 -1.202 -0.983 -1.145 -1.07 c -1.09 -1.154 -1.016 -1.224 -0.93 -1.275 c -0.833 -1.33 -0.722 -1.356 -0.611 -1.352 c -0.457 -1.357 -0.307 -1.301 -0.194 -1.195 c -0.078 -1.077 -0.005 -0.922 0.011 -0.757 c 0.587 -0.757 l 0.556 -1.055 0.419 -1.332 0.202 -1.538 c -0.022 -1.721 -0.306 -1.815 -0.595 -1.803 c -0.777 -1.806 -0.958 -1.771 -1.126 -1.7 c -1.293 -1.642 -1.445 -1.547 -1.57 -1.421 c -1.68 -1.297 -1.763 -1.151 -1.814 -0.993 c -1.87 -0.822 -1.898 -0.643 -1.896 -0.462 c -1.898 -0.276 -1.871 -0.091 -1.817 0.087 c -1.766 0.252 -1.682 0.405 -1.57 0.537 c -1.459 0.664 -1.323 0.766 -1.168 0.834 c -0.991 0.914 -0.798 0.955 -0.603 0.954 c -0.457 0.954 -0.311 0.935 -0.17 0.895 c -0.039 0.858 0.084 0.799 0.194 0.72 c 0.302 0.643 0.393 0.543 0.459 0.428 c 0.531 0.298 0.572 0.155 0.582 0.008 c 0 0.008 l 0 0 l f Q q 1 0 0 1 394.8712 733.5723 cm 0 0 m 0.577 0 l 0.577 -2.048 l 1.615 -0.985 l 2.322 -0.985 l 1.323 -1.944 l 2.417 -3.604 l 1.716 -3.604 l 0.919 -2.337 l 0.577 -2.669 l 0.577 -3.604 l 0 -3.604 l h f Q q 1 0 0 1 398.712 732.5762 cm 0 0 m 0.436 0 l 0.436 0.218 l 0.429 0.352 0.448 0.486 0.488 0.614 c 0.521 0.705 0.577 0.786 0.651 0.85 c 0.717 0.905 0.795 0.943 0.879 0.961 c 0.966 0.979 1.056 0.988 1.145 0.988 c 1.28 0.993 1.416 0.981 1.548 0.954 c 1.548 0.505 l 1.509 0.516 1.469 0.523 1.429 0.528 c 1.379 0.532 1.33 0.532 1.28 0.528 c 1.209 0.53 1.14 0.511 1.081 0.473 c 1.019 0.419 0.987 0.337 0.999 0.255 c 0.999 -0.011 l 1.498 -0.011 l 1.498 -0.441 l 1.009 -0.441 l 1.009 -2.622 l 0.436 -2.622 l 0.436 -0.428 l 0.005 -0.428 l 0.005 0 l 0 0 l f Q q 1 0 0 1 401.7535 729.8965 cm 0 0 m -0.191 -0.003 -0.381 0.032 -0.559 0.104 c -0.715 0.167 -0.856 0.264 -0.972 0.388 c -1.091 0.512 -1.181 0.659 -1.238 0.82 c -1.356 1.18 -1.356 1.567 -1.238 1.925 c -1.181 2.087 -1.091 2.234 -0.972 2.358 c -0.856 2.481 -0.715 2.578 -0.559 2.643 c -0.199 2.78 0.198 2.78 0.558 2.643 c 0.714 2.578 0.855 2.481 0.972 2.358 c 1.09 2.234 1.181 2.087 1.237 1.925 c 1.355 1.567 1.355 1.18 1.237 0.82 c 1.181 0.659 1.09 0.512 0.972 0.388 c 0.855 0.266 0.713 0.169 0.558 0.106 c 0.38 0.034 0.191 -0.002 0 0 c 0 0.454 m 0.115 0.451 0.23 0.479 0.332 0.534 c 0.424 0.586 0.502 0.659 0.562 0.746 c 0.624 0.836 0.669 0.936 0.695 1.041 c 0.752 1.26 0.752 1.491 0.695 1.71 c 0.669 1.816 0.625 1.916 0.562 2.005 c 0.502 2.091 0.423 2.163 0.332 2.215 c 0.123 2.323 -0.126 2.323 -0.335 2.215 c -0.427 2.163 -0.505 2.091 -0.566 2.005 c -0.628 1.916 -0.673 1.816 -0.699 1.71 c -0.756 1.491 -0.756 1.26 -0.699 1.041 c -0.672 0.936 -0.627 0.836 -0.566 0.746 c -0.506 0.659 -0.427 0.586 -0.335 0.534 c -0.232 0.478 -0.117 0.451 0 0.454 c f Q q 1 0 0 1 403.5515 732.5762 cm 0 0 m 0.531 0 l 0.531 -0.505 l 0.55 -0.43 0.583 -0.359 0.629 -0.297 c 0.681 -0.229 0.74 -0.167 0.807 -0.114 c 0.877 -0.059 0.956 -0.014 1.039 0.019 c 1.123 0.053 1.213 0.07 1.304 0.069 c 1.52 0.069 l 1.52 -0.486 l 1.395 -0.467 l 1.269 -0.467 l 1.178 -0.468 1.087 -0.488 1.004 -0.526 c 0.917 -0.565 0.839 -0.625 0.778 -0.699 c 0.716 -0.783 0.669 -0.878 0.643 -0.98 c 0.604 -1.104 0.584 -1.233 0.586 -1.362 c 0.586 -2.603 l 0.01 -2.603 l 0.01 0 l 0 0 l f Q q 1 0 0 1 409.0202 729.9683 cm 0 0 m -0.577 0 l -0.577 0.364 l -0.649 0.23 -0.759 0.121 -0.893 0.047 c -1.022 -0.029 -1.169 -0.07 -1.32 -0.072 c -1.595 -0.095 -1.866 0.002 -2.064 0.194 c -2.234 0.413 -2.316 0.687 -2.295 0.964 c -2.295 2.608 l -1.719 2.608 l -1.719 1.014 l -1.735 0.843 -1.689 0.67 -1.588 0.531 c -1.492 0.433 -1.357 0.382 -1.219 0.39 c -1.116 0.387 -1.012 0.406 -0.917 0.446 c -0.84 0.479 -0.772 0.531 -0.72 0.595 c -0.667 0.661 -0.63 0.738 -0.611 0.82 c -0.588 0.911 -0.577 1.003 -0.577 1.097 c -0.577 2.611 l 0 2.611 l 0 0 l f Q q 1 0 0 1 409.6413 732.5762 cm 0 0 m 0.545 0 l 0.545 -0.353 l 0.617 -0.209 0.736 -0.094 0.882 -0.026 c 1.03 0.04 1.19 0.073 1.352 0.072 c 1.535 0.075 1.717 0.038 1.883 -0.037 c 2.031 -0.106 2.161 -0.208 2.263 -0.334 c 2.366 -0.465 2.442 -0.615 2.489 -0.775 c 2.54 -0.948 2.566 -1.127 2.566 -1.307 c 2.566 -1.479 2.542 -1.651 2.497 -1.817 c 2.455 -1.973 2.385 -2.121 2.29 -2.252 c 2.099 -2.522 1.789 -2.682 1.458 -2.68 c 1.369 -2.681 1.28 -2.674 1.193 -2.659 c 1.11 -2.644 1.028 -2.618 0.951 -2.584 c 0.875 -2.552 0.802 -2.509 0.736 -2.457 c 0.671 -2.406 0.615 -2.343 0.571 -2.273 c 0.571 -3.575 l -0.005 -3.575 l -0.005 0 l 0 0 l 2.008 -1.307 m 2.008 -1.191 1.993 -1.076 1.963 -0.964 c 1.936 -0.859 1.89 -0.759 1.828 -0.669 c 1.768 -0.584 1.69 -0.514 1.599 -0.462 c 1.503 -0.409 1.395 -0.382 1.286 -0.385 c 1.072 -0.372 0.867 -0.467 0.738 -0.638 c 0.607 -0.836 0.543 -1.072 0.555 -1.31 c 0.554 -1.433 0.57 -1.557 0.603 -1.676 c 0.631 -1.781 0.68 -1.879 0.747 -1.965 c 0.809 -2.044 0.886 -2.109 0.975 -2.157 c 1.071 -2.206 1.178 -2.23 1.286 -2.229 c 1.401 -2.232 1.517 -2.205 1.618 -2.148 c 1.708 -2.096 1.785 -2.025 1.843 -1.939 c 1.903 -1.85 1.945 -1.751 1.968 -1.646 c 1.995 -1.535 2.008 -1.421 2.008 -1.307 c f Q q 1 0 0 1 415.1662 729.9683 cm 0 0 m -0.545 0 l -0.545 0.353 l -0.616 0.211 -0.734 0.099 -0.879 0.034 c -1.027 -0.031 -1.187 -0.065 -1.349 -0.064 c -1.532 -0.067 -1.714 -0.03 -1.88 0.045 c -2.028 0.113 -2.158 0.214 -2.26 0.34 c -2.364 0.47 -2.441 0.62 -2.486 0.781 c -2.538 0.958 -2.564 1.143 -2.563 1.328 c -2.568 1.536 -2.536 1.742 -2.468 1.938 c -2.41 2.097 -2.319 2.242 -2.202 2.364 c -2.101 2.471 -1.977 2.555 -1.838 2.608 c -1.705 2.659 -1.563 2.685 -1.421 2.685 c -1.338 2.685 -1.256 2.678 -1.174 2.664 c -1.091 2.648 -1.01 2.624 -0.932 2.589 c -0.855 2.556 -0.783 2.514 -0.717 2.462 c -0.652 2.411 -0.597 2.349 -0.553 2.279 c -0.553 3.606 l 0.024 3.606 l 0.024 0 l 0 0 l -2.008 1.277 m -2.009 1.166 -1.994 1.056 -1.965 0.948 c -1.939 0.845 -1.896 0.748 -1.835 0.661 c -1.777 0.578 -1.699 0.508 -1.61 0.459 c -1.404 0.355 -1.162 0.355 -0.956 0.459 c -0.866 0.512 -0.789 0.585 -0.73 0.671 c -0.671 0.762 -0.626 0.862 -0.6 0.966 c -0.572 1.076 -0.558 1.188 -0.558 1.301 c -0.543 1.542 -0.612 1.781 -0.751 1.979 c -0.88 2.14 -1.078 2.229 -1.283 2.22 c -1.402 2.224 -1.52 2.196 -1.623 2.138 c -1.714 2.083 -1.793 2.009 -1.852 1.92 c -1.911 1.828 -1.954 1.725 -1.977 1.617 c -1.999 1.505 -2.01 1.392 -2.008 1.277 c f Q q 1 0 0 1 417.9787 730.5499 cm 0 0 m -0.004 -0.052 0.005 -0.104 0.026 -0.151 c 0.052 -0.185 0.094 -0.202 0.136 -0.197 c 0.197 -0.197 l 0.223 -0.2 0.25 -0.2 0.276 -0.197 c 0.276 -0.595 l 0.199 -0.619 l 0.101 -0.64 l 0 -0.656 l -0.085 -0.656 l -0.187 -0.66 -0.288 -0.635 -0.377 -0.584 c -0.461 -0.528 -0.516 -0.437 -0.528 -0.337 c -0.648 -0.451 -0.792 -0.534 -0.951 -0.579 c -1.106 -0.628 -1.269 -0.654 -1.432 -0.656 c -1.546 -0.657 -1.659 -0.641 -1.769 -0.608 c -1.872 -0.579 -1.967 -0.531 -2.053 -0.468 c -2.136 -0.405 -2.203 -0.324 -2.25 -0.231 c -2.3 -0.127 -2.326 -0.012 -2.324 0.104 c -2.33 0.24 -2.299 0.375 -2.236 0.497 c -2.181 0.594 -2.101 0.675 -2.005 0.733 c -1.905 0.791 -1.795 0.833 -1.681 0.855 c -1.562 0.88 -1.442 0.899 -1.32 0.914 c -1.222 0.933 -1.123 0.947 -1.022 0.956 c -0.938 0.963 -0.855 0.977 -0.773 0.999 c -0.708 1.014 -0.649 1.046 -0.6 1.092 c -0.556 1.144 -0.533 1.211 -0.536 1.28 c -0.534 1.344 -0.553 1.408 -0.59 1.46 c -0.624 1.507 -0.668 1.544 -0.72 1.569 c -0.775 1.596 -0.834 1.613 -0.895 1.62 c -0.955 1.624 -1.016 1.624 -1.076 1.62 c -1.215 1.625 -1.354 1.591 -1.474 1.519 c -1.581 1.45 -1.647 1.333 -1.652 1.206 c -2.231 1.206 l -2.227 1.354 -2.185 1.498 -2.108 1.625 c -2.041 1.733 -1.951 1.824 -1.843 1.891 c -1.729 1.96 -1.603 2.007 -1.472 2.032 c -1.329 2.072 -1.183 2.098 -1.036 2.109 c -0.908 2.109 -0.781 2.096 -0.656 2.069 c -0.538 2.044 -0.425 2 -0.321 1.939 c -0.225 1.88 -0.143 1.8 -0.083 1.705 c -0.02 1.599 0.012 1.478 0.008 1.354 c 0.008 0.013 l 0 0 l -0.576 0.728 m -0.674 0.667 -0.785 0.631 -0.9 0.624 c -1.028 0.612 -1.155 0.594 -1.283 0.571 c -1.343 0.561 -1.402 0.547 -1.46 0.528 c -1.515 0.511 -1.566 0.485 -1.612 0.451 c -1.657 0.419 -1.692 0.376 -1.716 0.327 c -1.742 0.267 -1.755 0.203 -1.753 0.138 c -1.755 0.079 -1.735 0.021 -1.697 -0.024 c -1.661 -0.067 -1.615 -0.103 -1.564 -0.127 c -1.509 -0.154 -1.451 -0.171 -1.392 -0.181 c -1.335 -0.19 -1.278 -0.196 -1.222 -0.197 c -1.152 -0.196 -1.083 -0.188 -1.015 -0.173 c -0.94 -0.156 -0.87 -0.127 -0.805 -0.088 c -0.74 -0.048 -0.684 0.004 -0.64 0.066 c -0.594 0.134 -0.571 0.215 -0.574 0.297 c -0.574 0.725 l h f Q q 1 0 0 1 418.3371 732.5762 cm 0 0 m 0.434 0 l 0.434 0.784 l 0.996 0.784 l 0.996 0 l 1.527 0 l 1.527 -0.43 l 0.996 -0.43 l 0.996 -1.822 l 0.993 -1.874 0.993 -1.927 0.996 -1.979 c 1 -2.018 1.011 -2.056 1.031 -2.09 c 1.05 -2.122 1.079 -2.146 1.113 -2.159 c 1.162 -2.177 1.213 -2.185 1.265 -2.183 c 1.387 -2.183 l 1.428 -2.181 1.469 -2.175 1.509 -2.165 c 1.509 -2.608 l 1.323 -2.629 l 1.261 -2.633 1.199 -2.633 1.137 -2.629 c 1.013 -2.633 0.89 -2.619 0.771 -2.587 c 0.688 -2.564 0.613 -2.52 0.553 -2.459 c 0.499 -2.4 0.462 -2.328 0.446 -2.25 c 0.427 -2.155 0.416 -2.059 0.415 -1.963 c 0.415 -0.428 l -0.019 -0.428 l -0.019 0 l 0 0 l f Q q 1 0 0 1 420.7277 731.1235 cm 0 0 m 0 -0.099 0.014 -0.198 0.042 -0.292 c 0.068 -0.382 0.112 -0.466 0.17 -0.54 c 0.229 -0.611 0.303 -0.669 0.388 -0.709 c 0.486 -0.754 0.593 -0.776 0.701 -0.773 c 0.845 -0.78 0.987 -0.742 1.107 -0.664 c 1.216 -0.582 1.296 -0.468 1.336 -0.337 c 1.88 -0.337 l 1.827 -0.603 1.674 -0.838 1.456 -0.996 c 1.349 -1.073 1.231 -1.131 1.105 -1.169 c 0.973 -1.208 0.836 -1.228 0.699 -1.227 c 0.512 -1.23 0.327 -1.196 0.154 -1.126 c 0.003 -1.066 -0.133 -0.973 -0.244 -0.855 c -0.356 -0.73 -0.44 -0.583 -0.491 -0.422 c -0.548 -0.243 -0.576 -0.056 -0.574 0.133 c -0.575 0.313 -0.546 0.493 -0.486 0.664 c -0.426 0.826 -0.336 0.974 -0.221 1.102 c 0.002 1.374 0.334 1.532 0.685 1.535 c 0.877 1.539 1.067 1.495 1.238 1.408 c 1.396 1.326 1.535 1.209 1.644 1.067 c 1.753 0.922 1.833 0.757 1.878 0.582 c 1.927 0.396 1.939 0.203 1.915 0.013 c -0.002 0.013 l 0 0 l 1.341 0.377 m 1.335 0.468 1.315 0.557 1.283 0.643 c 1.253 0.724 1.209 0.798 1.153 0.863 c 1.096 0.926 1.027 0.978 0.951 1.014 c 0.868 1.054 0.777 1.074 0.685 1.073 c 0.594 1.073 0.504 1.055 0.419 1.02 c 0.339 0.986 0.267 0.937 0.207 0.874 c 0.147 0.81 0.099 0.735 0.066 0.653 c 0.031 0.569 0.011 0.479 0.008 0.388 c 1.349 0.388 l h f Q q 1 0 0 1 423.5192 730.7994 cm 0 0 m 0.002 -0.142 0.073 -0.274 0.191 -0.353 c 0.312 -0.423 0.45 -0.458 0.59 -0.454 c 0.651 -0.458 0.711 -0.458 0.773 -0.454 c 0.839 -0.447 0.904 -0.43 0.967 -0.406 c 1.024 -0.385 1.075 -0.349 1.116 -0.303 c 1.155 -0.252 1.174 -0.189 1.168 -0.125 c 1.166 -0.057 1.138 0.008 1.089 0.056 c 1.033 0.107 0.967 0.146 0.895 0.17 c 0.809 0.201 0.72 0.226 0.629 0.245 c 0.329 0.33 l 0.224 0.352 0.121 0.38 0.019 0.415 c -0.076 0.446 -0.166 0.491 -0.247 0.55 c -0.327 0.608 -0.391 0.683 -0.436 0.771 c -0.486 0.873 -0.511 0.986 -0.507 1.1 c -0.512 1.226 -0.475 1.351 -0.404 1.456 c -0.333 1.551 -0.243 1.63 -0.138 1.687 c -0.028 1.747 0.092 1.788 0.215 1.809 c 0.337 1.832 0.462 1.843 0.587 1.843 c 0.716 1.844 0.845 1.83 0.972 1.801 c 1.09 1.774 1.202 1.727 1.304 1.663 c 1.404 1.598 1.488 1.513 1.551 1.413 c 1.621 1.3 1.663 1.173 1.676 1.041 c 1.076 1.041 l 1.059 1.155 0.989 1.253 0.887 1.307 c 0.78 1.355 0.665 1.38 0.547 1.378 c 0.5 1.381 0.452 1.381 0.403 1.378 c 0.35 1.373 0.298 1.36 0.247 1.341 c 0.2 1.325 0.157 1.297 0.122 1.262 c 0.087 1.224 0.069 1.174 0.071 1.124 c 0.069 1.058 0.096 0.995 0.146 0.951 c 0.202 0.903 0.267 0.866 0.337 0.842 c 0.424 0.811 0.512 0.786 0.603 0.768 c 0.917 0.701 l 1.021 0.678 1.124 0.65 1.224 0.616 c 1.319 0.584 1.409 0.539 1.49 0.481 c 1.662 0.359 1.762 0.16 1.755 -0.05 c 1.76 -0.189 1.723 -0.326 1.649 -0.443 c 1.582 -0.551 1.491 -0.642 1.384 -0.709 c 1.267 -0.778 1.14 -0.827 1.007 -0.855 c 0.873 -0.885 0.735 -0.9 0.598 -0.9 c 0.443 -0.902 0.29 -0.883 0.141 -0.845 c 0.01 -0.812 -0.114 -0.753 -0.223 -0.674 c -0.324 -0.601 -0.407 -0.504 -0.465 -0.393 c -0.527 -0.269 -0.559 -0.131 -0.558 0.008 c 0.019 0.008 l 0 0 l f Q 0.146 0.941 0.992 0.044 k q 1 0 0 1 372.9062 729.3892 cm 0 0 m 3.612 2.406 l 3.612 5.296 l 0 5.296 l h f Q 0 0.889 0.676 0 k q 1 0 0 1 376.5186 729.3892 cm 0 0 m -3.612 2.406 l -3.612 5.296 l 0 5.296 l h f Q 0.694 0.076 0.209 0 k q 1 0 0 1 374.7125 735.3145 cm 0 0 m -2.2 0 -3.984 -1.784 -3.984 -3.984 c -3.984 -6.184 -2.2 -7.968 0 -7.968 c 2.2 -7.968 3.984 -6.184 3.984 -3.984 c 3.984 -1.784 2.2 0 0 0 c 0 -6.993 m -1.662 -6.993 -3.009 -5.646 -3.009 -3.984 c -3.009 -2.322 -1.662 -0.975 0 -0.975 c 1.662 -0.975 3.009 -2.322 3.009 -3.984 c 3.009 -5.646 1.662 -6.993 0 -6.993 c f Q 0 0.235 0.86 0 k q 1 0 0 1 376.9137 729.2803 cm 0 0 m -1.118 -1.208 -3.015 -1.281 -4.237 -0.159 c -5.159 0.688 -5.459 2.005 -4.999 3.156 c -5.833 3.687 l -6.736 1.681 -5.843 -0.679 -3.836 -1.582 c -2.218 -2.311 -0.312 -1.881 0.836 -0.528 c 0 0 l f Q 0 0 0 0.6 k q 1 0 0 1 369.1348 736.8087 cm 0 0 m -0.238 0 -0.432 -0.193 -0.432 -0.432 c -0.432 -10.524 l -0.432 -10.763 -0.238 -10.956 0 -10.956 c 57.901 -10.956 l 58.139 -10.956 58.333 -10.763 58.333 -10.524 c 58.333 -0.432 l 58.333 -0.193 58.139 0 57.901 0 c h 57.901 -11.155 m 0 -11.155 l -0.348 -11.155 -0.631 -10.872 -0.631 -10.524 c -0.631 -0.432 l -0.631 -0.084 -0.348 0.199 0 0.199 c 57.901 0.199 l 58.249 0.199 58.532 -0.084 58.532 -0.432 c 58.532 -10.524 l 58.532 -10.872 58.249 -11.155 57.901 -11.155 c f Q EMC Q endstream endobj 1601 0 obj <> endobj 1623 0 obj <>stream Adobe Illustrator CS6 (Windows) 2021-04-12T11:45:36+05:00 2021-06-02T10:28:09+05:00 2021-06-02T10:28:09+05:00 1 False False 20.868494 3.999928 Millimeters Cyan Magenta Yellow Black Default Swatch Group 0 C=0 M=24 Y=86 K=0 PROCESS 100.000000 CMYK 0.000000 23.504999 86.022697 0.000000 C=69 M=8 Y=21 K=0 PROCESS 100.000000 CMYK 69.369003 7.635600 20.892700 0.000000 C=0 M=89 Y=68 K=0 PROCESS 100.000000 CMYK 0.000000 88.946404 67.623398 0.000000 C=15 M=94 Y=99 K=4 PROCESS 100.000000 CMYK 14.578501 94.070297 99.160698 4.416000 C=0 M=0 Y=0 K=84 PROCESS 100.000000 CMYK 0.000000 0.000000 0.000000 84.000000 C=0 M=0 Y=0 K=35 PROCESS 100.000000 CMYK 0.000000 0.000000 0.000000 35.000000 C=0 M=0 Y=0 K=60 PROCESS 100.000000 CMYK 0.000000 0.000000 0.000000 60.000004 Document application/pdf proof:pdf xmp.did:804244B35A9BEB118A6FC3C256996E2F uuid:08e30110-bdb7-4606-97ca-63fb62cbcecc uuid:21079f76-f6d7-4329-b725-f2fb35af5114 uuid:722f8893-0b3c-4402-87fb-c713f1fa0e26 uuid:21079f76-f6d7-4329-b725-f2fb35af5114 uuid:21079f76-f6d7-4329-b725-f2fb35af5114 proof:pdf saved xmp.iid:804244B35A9BEB118A6FC3C256996E2F 2021-04-12T11:45:42+05:00 Adobe Illustrator CS6 (Windows) / endstream endobj 1622 0 obj <>/Border[0 0 0]/H/N/Rect[366.504 739.008 429.659 723.67]/Subtype/Link/Type/Annot>> endobj 1624 0 obj <> endobj 1478 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1479 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1480 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1481 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1482 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1630 0 obj [1632 0 R 1633 0 R 1634 0 R 1635 0 R 1636 0 R 1637 0 R 1638 0 R 1639 0 R 1640 0 R 1641 0 R 1642 0 R 1643 0 R 1644 0 R 1645 0 R 1646 0 R 1647 0 R 1648 0 R 1649 0 R 1650 0 R 1651 0 R 1652 0 R 1653 0 R 1654 0 R 1655 0 R 1656 0 R 1657 0 R 1658 0 R 1659 0 R 1660 0 R 1661 0 R 1662 0 R 1663 0 R 1664 0 R 1665 0 R 1666 0 R] endobj 1631 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.099 Tw 8 0 0 8 70.8661 731.2159 Tm (8.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(S)15(t)-32(ijns)]TJ /Span<>> BDC ( )Tj EMC [(RCH, de G)20(r)-33(aaf)]TJ /Span<>> BDC ( )Tj EMC [(EJR, P)20(unt)]TJ /Span<>> BDC ( )Tj EMC [(CJ)15(A, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. L)35(ong-ter)-16(m Oncol)30(o)-15.9(gical )]TJ 0.06 Tw -1.296 -1.25 Td [(and F)10(unc)-15.9(t)-32(ional Outcomes of Chemor)-32.9(adio)17(t)-13(her)-33(apy F)10(oll)30(o)-14(wed b)12(y Or)-32(gan-)]TJ 0.066 Tw 0 -1.25 TD [(Sp)32(ar)-37(ing T)50(r)-33(ansanal End)-16(oscopic Micr)-32(osur)-31.9(ger)-24(y for Dist)15.1(al R)13(ec)-16(t)15.1(al Cancer: )]TJ -0.053 Tw T* [(T)47(he C)20(AR)-11.9(T)25(S S)15(tud)17(y. )]TJ /T1_1 1 Tf [(J)30.1(AMA Surg)]TJ /T1_0 1 Tf [(. 2019 Jan 1;154\(1\):47\22654. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1001/)Tj T* [(jamasur)-31.9(g.2018.3752)]TJ 0 0 0 1 k /GS1 gs 0.138 Tw T* (9.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Ba)-17(ch)]TJ /Span<>> BDC ( )Tj EMC [(SP, Gilber)-21.9(t)]TJ /Span<>> BDC ( )Tj EMC [(A, Br)-32(o)-16(ck)]TJ /Span<>> BDC ( )Tj EMC [(K, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. R)-9.9(adical sur)-32(ger)-24(y ver)-9.9(sus or)-32(gan )]TJ 0.262 Tw -1.296 -1.25 Td [(p)25(r)-24(eser)-31.9(v)-15(a)15(t)-32(ion v)-16(ia shor)-22(t-cour)-9.9(se r)-33(adio)17(t)-13(her)-32.9(apy foll)30(o)-14(wed b)12(y tr)-33(ansanal )]TJ 0.033 Tw T* [(end)-16(oscopic micr)-32(osur)-32(ger)-23.9(y for ear)-30(l)35(y-st)15.1(a)-17(ge r)-23.9(ec)-16(t)15(al cancer \(TREC\): a r)-33(an)]TJ 0 Tw (-)Tj 0.104 Tw T* [(d)-16(omised, open-l)-16(abel feasibil)-30.9(i)-24(t)-9.9(y stud)17(y. )]TJ /T1_1 1 Tf (Lancet Gastroenterol Hepatol)Tj /T1_0 1 Tf 0 Tw (. )Tj 0.023 Tw T* [(2021 F)10(eb;6\(2\):92\226105. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1016/S2468-1253\(20\)30333-2)Tj 0 0 0 1 k /GS1 gs 0.061 Tw T* (10.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Gar)-32(c)-23.9(ia-A)-25(guil)-16(ar)]TJ /Span<>> BDC ( )Tj EMC [(J, P)40(a)15(t)-32(il)]TJ /Span<>> BDC ( )Tj EMC [(S, Goll)35.1(ub)]TJ /Span<>> BDC ( )Tj EMC [(MJ, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Or)-32(gan P)35(r)-23.9(eser)-32(v)-15(a)15(t)-32(ion in )]TJ -0.053 Tw -1.796 -1.25 Td [(P)40(a)15(t)-32(ients )0.5(W)-16(i)-24(t)-13(h R)13(ec)-16(t)15(al )0.5(A)15(deno)-16(car)-32(c)-24(inoma )0.5(T)49.9(r)-23.9(ea)15(ted W)-16(i)-24(t)-13(h )0.5(T)45(o)17(t)15(al Neoad)17(juv)-15(ant )]TJ 0 Tw T* [(T)47(her)-33(apy. )]TJ /T1_1 1 Tf -0.015 Tw 3.672 0 Td (J Clin Oncol)Tj /T1_0 1 Tf [(. 2022 A)10(ug 10;40\(23\):2546\2262556. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1200/)Tj -3.672 -1.25 Td [(JC)13(O.22.00032)]TJ 0 0 0 1 k /GS1 gs 0.294 Tw T* (11.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(T)40(emmink)]TJ /Span<>> BDC ( )Tj EMC 4.101 0 Td [(SJD, )0.5(P)30(ee)-12(ter)-9.9(s)]TJ /Span<>> BDC ( )Tj EMC 5.668 0 Td [(K)20(C, )0.5(Bahad)-16(oer)]TJ /Span<>> BDC ( )Tj EMC 5.992 0 Td [(RR, )0.5(e)-12(t)]TJ /Span<>> BDC ( )Tj EMC 3.123 0 Td [(al. )0.5(Inter)-14.9(na)15(t)-32(ional )]TJ 0.159 Tw -20.68 -1.25 Td [(W)12(a)15(tch & W)12(ai)-24(t Da)15(t)15(abase \(IWWD\) Consor)-22(t)-32(ium. W)12(a)15(tch and w)-12(ai)-24(t af)-28(ter )]TJ 0.071 Tw T* [(neoad)17(juv)-15(ant tr)-23.9(ea)15(tment in r)-24(ec)-16(t)15(al cancer: com)10(p)32.1(ar)-37(ison of outcomes in )]TJ 0.021 Tw T* [(p)32(a)15(t)-32(ients wi)-24(t)-13(h and wi)-23.9(t)-13(hout a com)10(ple)-12(te r)-24(esponse a)15(t f)-28(ir)-10(st r)-24(eassess)26(ment )]TJ 0.029 Tw T* [(in )0.5(t)-13(he Inter)-14.9(na)15(t)-32(ional )0.5(W)12(a)15(tch )0.5(& W)12(ai)-24(t )0.5(Da)15(t)15(abase )0.5(\(IWWD\). )]TJ /T1_1 1 Tf 21.519 0 Td [(Br )0.5(J Surg)]TJ /T1_0 1 Tf (. 2023 )Tj 0.023 Tw -21.519 -1.25 Td [(Ma)15(y 16;110\(6\):676\226684. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1093/bjs/znad051)Tj 0 0 0 1 k /GS1 gs 0.241 Tw T* (12.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Geubels)Tj /Span<>> BDC ( )Tj EMC [(BM, Me)-10.9(yer)]TJ /Span<>> BDC ( )Tj EMC [(VM, v)-15(an W)22(estr)-24(eenen)]TJ /Span<>> BDC ( )Tj EMC [(HL, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC (al. On Behalf )Tj 0.191 Tw -1.796 -1.25 Td [(O)-32(f T)47(he Dutch W)12(a)15(tch And W)12(ai)-24(t Consor)-21.9(t)-32(ium. R)11(ole of L)35(o)-16(cal E)35(x)-13(c)-24(ision )]TJ 0.222 Tw T* [(for Suspec)-16(ted R)13(egr)-31.9(o)-14(w)-24(t)-13(h in a W)12(a)15(tch and W)12(ai)-24(t S)15(tr)-32.9(a)14.9(teg)16.1(y for R)13(ec)-16(t)15(al )]TJ 0 Tw T* (Cancer. )Tj /T1_1 1 Tf 0.201 Tw 3.398 0 Td (Cancers \(Basel\).)Tj /T1_0 1 Tf [( 2022 Jun 23;14\(13\):3071. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.3390/)Tj -3.398 -1.25 Td [(cancer)-10(s14133071)]TJ 0 0 0 1 k /GS1 gs 0.044 Tw T* (13.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(L)70(ynn)]TJ /Span<>> BDC ( )Tj EMC [(PB, V)25(an der V)25(alk)]TJ /Span<>> BDC ( )Tj EMC [(MJM, Cl)-16(aassen)]TJ /Span<>> BDC ( )Tj EMC [(YHM, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Chemor)-33(adia)15(t)-32(ion )]TJ 0.087 Tw -1.796 -1.25 Td [(and L)35(o)-16(cal E)35(x)-12.9(c)-24(ision V)30(er)-9.9(sus T)45(o)17(t)15(al Mesor)-23.9(ec)-16(t)15(al E)35(x)-13(c)-24(ision for T2N0 R)13(ec)-16(t)15(al )]TJ 0.335 Tw T* [(Cancer: Com)10.1(p)31.9(ar)-36.9(ison of S)-16(hor)-22(t- and L)35(ong-T)40(er)-16(m Outcomes F)10(r)-31.9(om 2 )]TJ 0.011 Tc 0.414 Tw T* [(P)34.8(r)-32.1(ospec)-16.1(t)-32.2(i)-16.1(ve S)14.9(tudies. )]TJ /T1_1 1 Tf (Ann Surg.)Tj /T1_0 1 Tf [( 2023 Jan 1;277\(1\):e96\226e102.)11( )]TJ 0 Tc 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td [(10.1097/SL)-35(A.0000000000005052)]TJ 0 0 0 1 k /GS1 gs 0.002 Tw -1.847 -1.25 Td (14.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Gonz\341lez)Tj /Span<>> BDC ( )Tj EMC [(JEB, L)-31.9(aver)-15(nia)]TJ /Span<>> BDC ( )Tj EMC [(HC, F)10(r)-33(a)-17(ga)]TJ /Span<>> BDC ( )Tj EMC [(JGP, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. L)35(ong-ter)-15.9(m outcomes )]TJ 0.03 Tw -1.796 -1.25 Td [(of tr)-33(ansanal end)-16(oscopic micr)-31.9(osur)-32(ger)-24(y for cl)-31(inical com)10(ple)-12(te r)-23.9(esponse )]TJ -0.006 Tw T* [(af)-28(ter neoad)17(juv)-15(ant tr)-24(ea)15(tment in T2-3 r)-23.9(ec)-16(t)15(al cancer. )]TJ /T1_1 1 Tf (Surg Endosc.)Tj /T1_0 1 Tf ( 2022 )Tj 0.023 Tw T* [(Ma)15(y;36\(5\):2906\2262913. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1007/s00464-021-08583-y)Tj 0 0 0 1 k /GS1 gs -0.012 Tw T* (15.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Busha)15(t)-32(i)]TJ /Span<>> BDC ( )Tj EMC [(M, P)20(ucc)-23.9(iar)-24(ell)-30.9(i)]TJ /Span<>> BDC ( )Tj EMC [(S, Gennar)-31.9(o)]TJ /Span<>> BDC ( )Tj EMC [(N, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. L)35(o)-16(cal e)-18(x)-12.9(c)-24(ision in r)-24(ec)-16(t)15(al )]TJ 0.074 Tw -1.796 -1.25 Td [(cancer p)32(a)15(t)-32(ients wi)-24(t)-13(h major or com)10.1(ple)-12(te cl)-31(inical r)-24(esponse af)-28(ter neo)]TJ 0 Tw (-)Tj 0.129 Tw T* [(ad)17(juv)-15(ant )0.5(t)-13(her)-33(apy: )0.5(a case-ma)15(tched )0.5(stud)17(y. )]TJ /T1_1 1 Tf [(Int )0.5(J Colorectal )0.5(Dis.)]TJ /T1_0 1 Tf ( 2019 )Tj 0.023 Tw T* [(Dec;34\(12\):2129\2262136. d)-15.9(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1007/s00384-019-03420-0)Tj 0 0 0 1 k /GS1 gs 0.084 Tw T* (16.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Gar)-32(c)-23.9(ia-A)-25(guil)-16(ar)]TJ /Span<>> BDC ( )Tj EMC [(J, R)13(enfr)-31.9(o)]TJ /Span<>> BDC ( )Tj EMC [(L)-34.9(A, Cho)-14(w)]TJ /Span<>> BDC ( )Tj EMC [(OS, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Or)-32(gan p)25(r)-24(eser)-31.9(v)-15(a)15(t)-32(ion )]TJ 0.017 Tw -1.796 -1.25 Td [(for cl)-31(inical T2N0 dist)15(al r)-23.9(ec)-16(t)15(al cancer using neoad)17(juv)-15(ant chemor)-32.9(adio)]TJ 0 Tw (-)Tj 0.017 Tw T* [(t)-13(her)-33(apy and l)30(o)-16(cal e)-17.9(x)-13(c)-24(ision \(A)16(C)13(OSOG Z6041\): r)-24(esul)56.1(ts of an open-l)-15.9(abel, )]TJ 0.267 Tw T* [(single-ar)-15.9(m, mul)56(t)-32(i-inst)-32(i)-24(tut)-32(ional, phase 2 tr)-36.9(ial. )]TJ /T1_1 1 Tf (Lancet Oncol.)Tj /T1_0 1 Tf ( 2015 )Tj 0.023 Tw T* [(N)-14(ov;16\(15\):1537\2261546. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1016/S1470-2045\(15\)00215-6)Tj 0 0 0 1 k /GS1 gs 0.228 Tw T* (17.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Rull)-31(ier)]TJ /Span<>> BDC ( )Tj EMC [(E, R)10.9(ouane)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(P, T)60.1(uech)]TJ /Span<>> BDC ( )Tj EMC [(JJ, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Or)-32(gan p)25(r)-24(eser)-32(v)-15(a)15(t)-32(ion for )]TJ 0.175 Tw -1.796 -1.25 Td [(r)-24(ec)-16(t)15.1(al cancer \(GRECC)20(AR 2\): a p)25(r)-32(ospec)-16(t)-32(i)-16(ve, r)-33(and)-16(omised, open-l)-16(abel, )]TJ -0.001 Tw T* [(mul)56(t)-32(icentr)-23.9(e, phase 3 tr)-37(ial. )]TJ /T1_1 1 Tf 0 Tw (Lancet.)Tj /T1_0 1 Tf -0.001 Tw ( 2017 Jul 29;390\(10093\):469\226479. )Tj 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1016/S0140-6736\(17\)31056-5)Tj 0 0 0 1 k /GS1 gs 0.002 Tc 0.349 Tw -1.847 -1.25 Td (18.)Tj /Span<>> BDC ( )Tj EMC 1.804 0 Td (Jones)Tj /Span<>> BDC ( )Tj EMC (H, Al-Najami)Tj /Span<>> BDC ( )Tj EMC (I, Cunningham)Tj /Span<>> BDC ( )Tj EMC [(C. Q)-15.9(ual)-30.9(i)-23.9(t)-9.9(y of l)-30.9(ife af)-27.9(ter)2( )]TJ 0 Tc 0.067 Tw -1.804 -1.25 Td [(r)-24(ec)-16(t)15.1(al-p)25(r)-24(eser)-32(v)-16(ing tr)-24(ea)15(tment of r)-24(ec)-16(t)15(al cancer. )]TJ /T1_1 1 Tf (Eur J Surg Oncol.)Tj /T1_0 1 Tf ( 2020 )Tj 0.023 Tw T* [(N)-14(ov;46\(11\):2050\2262056. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1016/j.ejso.2020.07.018)Tj 0 0 0 1 k /GS1 gs -0.006 Tw T* (19.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Ar)-24(ef)]TJ /Span<>> BDC ( )Tj EMC [(A, A)-14(bd)42(all)-16(a)]TJ /Span<>> BDC ( )Tj EMC [(A, Dr)-24(el)-31(ichman)]TJ /Span<>> BDC ( )Tj EMC [(ER. T)47(he R)11(ole of L)35(o)-16(cal E)35(x)-13(c)-24(ision af)-28(ter )]TJ 0.008 Tw -1.796 -1.25 Td [(Neoad)17(juv)-15(ant T)47(her)-32.9(apy for L)35(o)-16(call)35(y A)15(d)-17(v)-15(anced R)13(ec)-16(t)15(al Cancer: A Dif)-56(fer)-23.9(ent )]TJ 0 Tw T* [(P)30(er)-10(spec)-15.9(t)-32(i)-16(ve. )]TJ /T1_1 1 Tf 0.249 Tw 5.452 0 Td [(Clin Colon R)21(ectal Surg.)]TJ /T1_0 1 Tf [( 2022 N)-14(ov 29;36\(4\):290\226294. )]TJ 0 Tw -5.452 -1.25 Td [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1055/s-0042-1758808)Tj 0 0 0 1 k /GS1 gs 0.16 Tw -1.847 -1.25 Td (20.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Ser)-24(r)-33(a-Ar)-32.9(a)-17(c)-24(il)]TJ /Span<>> BDC ( )Tj EMC [(X, P)30(er)-37(ica)15(y)]TJ /Span<>> BDC ( )Tj EMC [(C, Badia-Cl)30(osa)]TJ /Span<>> BDC ( )Tj EMC [(J, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. S)-16(hor)-22(t-ter)-15.9(m out)]TJ 0 Tw (-)Tj 0.128 Tw -1.796 -1.25 Td [(comes of chemor)-33(adio)17(t)-12.9(her)-33(apy and l)30(o)-16(cal e)-17.9(x)-13(c)-24(ision ver)-10(sus t)17(o)17(t)15(al meso)]TJ 0 Tw (-)Tj 0.225 Tw T* [(r)-24(ec)-16(t)15.1(al e)-18(x)-13(c)-23.9(ision in T2-T3ab,N0,M0 r)-24(ec)-16(t)15.1(al cancer: a mul)56(t)-32(icentr)-23.9(er)-33(an)]TJ 0 Tw (-)Tj 0.044 Tw T* [(d)-16(omised, contr)-32(olled, phase III tr)-37(ial \(t)-13(he T)35(A)17(U-TEM stud)17(y\). )]TJ /T1_1 1 Tf (Ann Oncol)Tj /T1_0 1 Tf 0 Tw (. )Tj 0.023 Tw T* [(2023 Jan;34\(1\):78\22690. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1016/j.annonc.2022.09.160)Tj 0 0 0 1 k /GS1 gs 0.201 Tw T* (21.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Hall)-16(am)]TJ /Span<>> BDC ( )Tj EMC (S, Messenger)Tj /Span<>> BDC ( )Tj EMC [(DE, T)47(homas)]TJ /Span<>> BDC ( )Tj EMC [(MG. A Sy)-13(stema)15(t)-32(ic R)13(ev)-16(iew of )]TJ 0.266 Tw -1.796 -1.25 Td [(L)35(o)-16(cal E)35(x)-13(c)-24(ision Af)-28(ter Neoad)17.1(juv)-15(ant T)47.1(her)-33(apy for R)13(ec)-16(t)15(al Cancer: Ar)-23.9(e )]TJ 0.065 Tw 29.055 75 Td [(ypT0 T)59.9(umor)-9.9(s t)-13(he L)-32(imi)-23.9(t? )]TJ /T1_1 1 Tf [(Dis Colon R)21(ectum)]TJ /T1_0 1 Tf [(. 2016 O)-16(c)-16(t;59\(10\):984\22697. )]TJ 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1097/DCR.0000000000000613)Tj 0 0 0 1 k /GS1 gs 0.294 Tw -1.847 -1.25 Td (22.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(v)-15(an )0.5(G)20(r)-32(oningen)]TJ /Span<>> BDC ( )Tj EMC 6.661 0 Td [(JT, )0.5(v)-15(an )0.5(Ha)-17(gen)]TJ /Span<>> BDC ( )Tj EMC 6.694 0 Td [(P, )0.5(T)45(ollenaar)]TJ /Span<>> BDC ( )Tj EMC 5.41 0 Td [(RA, )0.5(e)-12(t)]TJ /Span<>> BDC ( )Tj EMC 3.15 0 Td [(al. )0.5(Dutch )]TJ 0.009 Tc 0.352 Tw -23.711 -1.25 Td [(Col)29.6(or)-24.4(ec)-16.4(t)14.6(al A)9.6(udi)-24.4(t. Ev)-15.4(al)34.6(ua)14.6(t)-32.4(ion of a Com)9.6(ple)-12.3(t)-32.4(ion T)44.6(o)16.6(t)14.7(al Mesor)-24.4(ec)-16.4(t)14.7(al)9( )]TJ 0 Tc 0.157 Tw T* [(E)35(x)-13(c)-23.9(ision in P)40(a)15.1(t)-32(ients Af)-28(ter L)35(o)-16(cal E)35(x)-13(c)-23.9(ision of R)12.9(ec)-15.9(t)15(al Cancer: A W)20(or)-24(d )]TJ 0.006 Tc 0.349 Tw T* [(of Caut)-31.8(ion. )]TJ /T1_1 1 Tf [(J N)18.2(atl Com)16.2(p)46.2(r Canc N)18.2(etw)]TJ /T1_0 1 Tf [(. 2018 Jul;16\(7\):822\226828.)6( )]TJ 0 Tc 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.6004/jnccn.2018.7026)Tj 0 0 0 1 k /GS1 gs 0.178 Tw -1.847 -1.25 Td (23.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(P)40(ar)-24(k)]TJ /Span<>> BDC ( )Tj EMC 2.13 0 Td [(SH, )0.5(Cho)]TJ /Span<>> BDC ( )Tj EMC 3.566 0 Td [(SH, )0.5(Choi)]TJ /Span<>> BDC ( )Tj EMC 3.845 0 Td [(SH, )0.5(e)-12(t)]TJ /Span<>> BDC ( )Tj EMC 2.911 0 Td [(al. )0.6(MRI )0.5(Assess)26(ment )0.6(of )0.5(Com)10(ple)-11.9(te )]TJ 0.021 Tw -14.248 -1.25 Td [(R)13(esponse t)17(o P)35(r)-24(eoper)-32.9(a)15(t)-32(i)-16(ve Chemor)-33(adia)15.1(t)-32(ion T)47(her)-33(apy for R)13(ec)-16(t)15(al Cancer: )]TJ 0.29 Tw T* [(2020 Guide for P)35(r)-33(a)-17(c)-16(t)-32(ice fr)-32(om t)-12.9(he K)25(or)-23.9(ean S)-15.9(o)-16(c)-24(ie)-12(t)-10(y of A)-14(bd)-16(ominal )]TJ 0 Tw T* [(R)-10(adiol)30(o)-16(g)16(y. )]TJ /T1_1 1 Tf 0.344 Tw 4.826 0 Td [(K)18(orean J R)20(adiol.)]TJ /T1_0 1 Tf [( 2020;21\(7\):812\226828. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.3348/)Tj -4.826 -1.25 Td (kjr.2020.0483)Tj 0 0 0 1 k /GS1 gs 0.262 Tw T* (24.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(F)10(elder)]TJ /Span<>> BDC ( )Tj EMC [(SI, P)40(a)15(t)-32(il)]TJ /Span<>> BDC ( )Tj EMC [(S, K)25(enned)17.1(y)]TJ /Span<>> BDC ( )Tj EMC [(E, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. )0.5(End)-16(oscopic F)10(ea)15(tur)-24(e and )]TJ 0.226 Tw -1.796 -1.25 Td [(R)13(esponse R)13(ep)25(r)-32(oduc)-24(ibil)-30.9(i)-24(t)-10(y in T)60(umor Assess)26(ment af)-28(ter Neoad)17(juv)-14.9(ant )]TJ 0.046 Tw T* [(T)47(her)-33(apy for R)13(ec)-16(t)15(al A)15(deno)-16(car)-31.9(c)-24(inoma. )]TJ /T1_1 1 Tf (Ann Surg Oncol.)Tj /T1_0 1 Tf ( 2021 28:5205\226)Tj 0.023 Tw T* [(5223. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1245/s10434-021-09827-w)Tj 0 0 0 1 k /GS1 gs 0.316 Tw T* (25.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(K)25(o)]TJ /Span<>> BDC ( )Tj EMC (HM, Choi)Tj /Span<>> BDC ( )Tj EMC [(YH, L)35(ee)]TJ /Span<>> BDC ( )Tj EMC [(JE, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Combina)15(t)-32(ion Assess)26(ment of )]TJ 0.032 Tw -1.796 -1.25 Td [(Cl)-31(inical Com)10(ple)-12(te R)13(esponse of P)40.1(a)15(t)-32(ients W)-16(i)-24(t)-12.9(h R)13(ec)-16(t)15(al Cancer F)10(oll)30.1(o)-14(wing )]TJ 0.012 Tc 0.452 Tw T* [(Chemor)-33.2(adio)16.8(t)-13.2(her)-33.2(apy W)-16.2(i)-24.2(t)-13.2(h End)-16.2(oscopy and Ma)-17.2(gne)-12.2(t)-32.3(ic R)12.8(esonance)12( )]TJ 0 Tc 0 Tw T* [(Ima)-17(ging. )]TJ /T1_1 1 Tf 0.135 Tw 4.037 0 Td [(Ann Colop)46(roctol.)]TJ /T1_0 1 Tf [( 2019 A)10(ug;35\(4\):202\226208. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.3393/)Tj -4.037 -1.25 Td [(a)-17(c.2018.10.15)]TJ 0 0 0 1 k /GS1 gs -0.006 Tw T* (26.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Sant)-32(ia)-17(go)]TJ /Span<>> BDC ( )Tj EMC 3.814 0 Td [(I, )0.5(Bar)-32.9(a)15(t)15(a)]TJ /Span<>> BDC ( )Tj EMC 3.617 0 Td [(M, )0.5(F)-19(igueir)-23.9(ed)-16(o)]TJ /Span<>> BDC ( )Tj EMC 5.615 0 Td [(N, )0.5(e)-11.9(t)]TJ /Span<>> BDC ( )Tj EMC 2.058 0 Td [(al. )0.6(T)47(he )0.5(spl)-31(i)-24(t )0.6(scar )0.5(sign )0.6(as )0.5(an )]TJ 0.053 Tw -16.9 -1.25 Td [(indica)15(t)17(or of sust)15(ained com)10(ple)-12(te r)-24(esponse af)-28(ter neoad)17(juv)-15(ant t)-13(her)-32.9(apy )]TJ 0.028 Tw T* [(in r)-24(ec)-15.9(t)15(al cancer. )]TJ /T1_1 1 Tf [(Eur R)20(adiol)]TJ /T1_0 1 Tf [(. 2020 Jan;30\(1\):224\226238. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1007/)Tj T* (s00330-019-06348-9)Tj 0 0 0 1 k /GS1 gs 0.018 Tw T* (27.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Na)-17(g)17(tegaal)]TJ /Span<>> BDC ( )Tj EMC [(ID, Gl)35(ynne-Jones)]TJ /Span<>> BDC ( )Tj EMC [(R. Ho)-14(w t)17(o measur)-24(e tumour r)-24(esponse )]TJ -0.028 Tw -1.796 -1.25 Td [(in r)-24(ec)-16(t)15(al cancer? An e)-18(xpl)-16(ana)15(t)-32(ion of discr)-24(ep)32(anc)-24(ies and suggest)-32(ions for )]TJ 0 Tw T* [(im)10(p)25(r)-32(ovement. )]TJ /T1_1 1 Tf 0.004 Tw 5.817 0 Td [(Cancer T)56(reat R)21(ev)]TJ /T1_0 1 Tf [(. 2020 Mar;84:101964. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1016/j.)Tj -5.817 -1.25 Td [(c)-16(tr)-32(v.2020.101964)]TJ 0 0 0 1 k /GS1 gs 0.048 Tw T* (28.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Smi)-24(t)-12.9(h)]TJ /Span<>> BDC ( )Tj EMC 2.651 0 Td [(FM, )0.5(Ahad)]TJ /Span<>> BDC ( )Tj EMC 3.875 0 Td [(A, )0.6(P)30(er)-24(ez)]TJ /Span<>> BDC ( )Tj EMC 3.473 0 Td [(RO, )0.5(e)-12(t)]TJ /Span<>> BDC ( )Tj EMC 2.66 0 Td [(al. )0.5(L)35.1(o)-16(cal )0.5(E)35(x)-13(c)-23.9(ision )0.5(T)40(echniques )0.6(for )]TJ 0.149 Tw -14.455 -1.25 Td [(R)13(ec)-16(t)15(al )0.6(Cancer )0.6(Af)-28(ter )0.6(Neoad)17(juv)-15(ant )0.6(Chemor)-33(adio)17(t)-12.9(her)-33(apy: )0.6(Wha)15(t )0.5(Ar)-23.9(e )0.5(W)22(e )]TJ 0 Tw T* (Doing? )Tj /T1_1 1 Tf 0.187 Tw 3.2 0 Td [(Dis Colon R)21(ectum)]TJ /T1_0 1 Tf [(. 2017 F)10(eb;60\(2\):228\226239. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1097/)Tj -3.2 -1.25 Td (DCR.0000000000000749)Tj 0 0 0 1 k /GS1 gs -0.023 Tw T* (29.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Bao)Tj /Span<>> BDC ( )Tj EMC 1.718 0 Td [(QR, )0.6(F)10(er)-24(r)-33(ar)-37(i)]TJ /Span<>> BDC ( )Tj EMC 4.351 0 Td [(S, )0.6(Capell)-31(i)]TJ /Span<>> BDC ( )Tj EMC 3.794 0 Td [(G, )0.6(e)-12(t)]TJ /Span<>> BDC ( )Tj EMC 1.972 0 Td [(al. )0.6(R)13(ec)-16(t)15(al )0.5(Sp)32(ar)-37(ing )0.6(App)25(r)-32(oa)-17(ches )0.6(af)-28(ter )]TJ 0.096 Tw -13.631 -1.25 Td [(Neoad)17(juv)-15(ant T)50(r)-24(ea)15.1(tment for R)13(ec)-16(t)15(al Cancer: A Sy)-13(stema)15(t)-31.9(ic R)13(ev)-16(iew and )]TJ 0.009 Tw T* [(Me)-12(t)15(a-Anal)35.1(y)-13(sis Com)10(p)32(ar)-36.9(ing L)35(o)-16(cal E)35(x)-13(c)-23.9(ision and W)12(a)15(tch and W)12(ai)-23.9(t. )]TJ /T1_1 1 Tf 0 Tw (Cancers )Tj T* (\(Basel\).)Tj /T1_0 1 Tf 0.023 Tw [( 2023 Jan 11;15\(2\):465. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw [(10.3390/cancer)-9.9(s15020465)]TJ 0 0 0 1 k /GS1 gs -0.012 Tw T* (30.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(P)30(er)-24(ez)]TJ /Span<>> BDC ( )Tj EMC (RO, Habr-Gama)Tj /Span<>> BDC ( )Tj EMC [(A, S\343o Jul)-31(i\343o)]TJ /Span<>> BDC ( )Tj EMC [(GP, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. T)50(r)-33(ansanal end)-16(oscop)]TJ 0 Tw (-)Tj 0.064 Tw -1.796 -1.25 Td [(ic micr)-32(osur)-31.9(ger)-24(y for r)-23.9(esidual r)-24(ec)-16(t)15(al cancer af)-28(ter neoad)17(juv)-15(ant chemo)]TJ 0 Tw (-)Tj 0.049 Tw T* [(r)-33(adia)15(t)-31.9(ion t)-13(her)-33(apy is asso)-16(c)-24(ia)15.1(ted wi)-24(t)-13(h signif)-28(icant immedia)15(te p)32(ain and )]TJ 0.277 Tw T* [(hospi)-24(t)15.1(al r)-24(eadmission )0.5(r)-33(a)15(tes. )]TJ /T1_1 1 Tf [(Dis Colon )0.5(R)21(ectum.)]TJ /T1_0 1 Tf ( 2011 54:545\226551. )Tj 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1007/DCR.0b013e3182083b84)Tj 0 0 0 1 k /GS1 gs -0.01 Tw -1.847 -1.25 Td (31.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Calmels)Tj /Span<>> BDC ( )Tj EMC [(M, L)-32(abiad)]TJ /Span<>> BDC ( )Tj EMC [(C, L)35(el)30(ong)]TJ /Span<>> BDC ( )Tj EMC [(B, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. L)35(o)-16(cal e)-18(x)-13(c)-23.9(ision af)-28(ter neoad)17(ju)]TJ 0 Tw (-)Tj -0.025 Tw -1.796 -1.25 Td [(v)-15(ant chemor)-32.9(adio)17(t)-13(her)-33(apy for mid and l)30(o)-14(w r)-24(ec)-16(t)15(al cancer: a mul)56.1(t)-32(icentr)-37(ic )]TJ 0.142 Tw T* [(F)10(r)-24(ench stud)16.9(y fr)-31.9(om t)-13(he GRECC)20(AR gr)-32(oup. )]TJ /T1_1 1 Tf (Colorectal Dis.)Tj /T1_0 1 Tf ( 2023 Sep 7. )Tj 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1111/codi.16742)Tj 0 0 0 1 k /GS1 gs 0.01 Tc 0.373 Tw -1.847 -1.25 Td (32.)Tj /Span<>> BDC ( )Tj EMC 1.836 0 Td (\202\r\007\036\036\027\022\024)Tj /Span<>> BDC ( )Tj EMC (\200.\202., \203\036\r\024\035\034\f\022\017\b)Tj /Span<>> BDC ( )Tj EMC (\202.\202., \207\030\024\007\f\022\017\005)Tj /Span<>> BDC ( )Tj EMC (\202.\217., \017)Tj /Span<>> BDC ( )Tj EMC 23.592 0 Td [(\f\024\026\r.)10( )]TJ 0 Tc 0.134 Tw -25.428 -1.25 Td [(\230\030\026\027\f\026\027\026\035\034\027\026\016 )0.5(\220\027\007\024\f\022\024\023\017\004\036\f\022\026\016 \n\017\022\030\024\ \b\017\030\031\030\020\017\016 \r)]TJ /Span<>> BDC ( )Tj EMC (\035\036\004\036\027\017\017 \002\024\035\034)Tj 0 Tw (-)Tj 0.147 Tw T* (\027\t\b \f)Tj /Span<>> BDC ( )Tj EMC (\007\024\002\030\024\022\026\004\036\f\021\r\036\027\027\t\n\017 \027\024\ \r\024\024\002\030\026\024\r\026\027\017\016\n\017 \017)Tj /Span<>> BDC ( )Tj EMC (\030\026\027\027\017\n \030\026\022\024\n )Tj -0.002 Tw T* (\023\030\016\n\024\005 \022\017\001\022\017. )Tj /T1_1 1 Tf (\207\025\005\025\032\t\013\025\017 \n\021\013\n\023\n\202\025\006\031\t\013\ \025\017 \204\205\032\021\026\023.)Tj /T1_0 1 Tf ( 2021;20\(6\):13\226)Tj 0.318 Tw T* [(22. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.21294/1814-4861-2021-20-6-13-22)Tj 0 0 0 1 k /GS1 gs 0.318 Tw [( / A)15(v)12(deenko)]TJ /Span<>> BDC ( )Tj EMC (V.A., )Tj 0.051 Tw T* [(Nevolsk)-15.9(ikh)]TJ /Span<>> BDC ( )Tj EMC [(A.A., Br)-32(odsk)-31.9(y)]TJ /Span<>> BDC ( )Tj EMC [(A.R., e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. T)50(r)-32.9(ansanal end)-16(oscopic micr)-32(osur)]TJ 0 Tw 27.286 0 Td (-)Tj 0.104 Tw -27.286 -1.25 Td [(ger)-24(y in t)-13(he tr)-24(ea)15(tment of p)32(a)15(t)-32(ients wi)-23.9(t)-13(h benign neopl)-16(as)26(ms and ear)-30(l)35(y )]TJ 0.147 Tw T* [(r)-24(ec)-15.9(t)15(al cancer. )]TJ /T1_1 1 Tf [(Siber)-37(ian Jour)-14(nal of Oncology)]TJ /T1_0 1 Tf (. 2021;20\(6\):13\22622. \(in )Tj 0.023 Tw T* [(Russ.\). d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.21294/1814-4861-2021-20-6-13-22)Tj 0 0 0 1 k /GS1 gs 0.206 Tw T* (33.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(P)30(el)56(tr)-36.9(ini)]TJ /Span<>> BDC ( )Tj EMC [(R., Im)10.1(per)-33(a)15(t)17(or)-24(e)]TJ /Span<>> BDC ( )Tj EMC [(N., Di Nuz)-24(zo)]TJ /Span<>> BDC ( )Tj EMC [(M.M. e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. T)45(o)-14(w)-12(ar)-24(ds per)]TJ 0 Tw 25.49 0 Td (-)Tj 0.139 Tw -27.286 -1.25 Td [(sonal)-31(ized )0.6(tr)-24(ea)15(tment )0.5(of )0.5(T2N0 )0.6(r)-24(ec)-16(t)15(al )0.6(cancer: )0.6(A )0.5(sy)-13(stema)15.1(t)-32(ic )0.6(r)-24(ev)-16(iew )0.6(of )]TJ 0.032 Tw T* [(l)30(ong-ter)-15.9(m )0.5(oncol)30(o)-16(gical )0.5(outcomes )0.6(of )0.6(neoad)17(juv)-15(ant )0.6(t)-13(her)-33(apy )0.6(foll)30(o)-14(wed )0.6(b)12(y )]TJ 0.062 Tw T* [(l)30(o)-16(cal e)-17.9(x)-13(c)-24(ision. )]TJ /T1_1 1 Tf (J Gastroenterol Hepatol)Tj /T1_0 1 Tf [(. 2022 A)10(ug;37\(8\):1426\2261433. )]TJ 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1111/jgh.15898)Tj /T1_2 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\033\030\031\030\213\b)-20.9(\035\231\213\233\t \021\032)50(\b)42(\032\231\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj -51.938 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 23, \023\0221)69(, 202)69(4)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 23, \023\0221)69(, 202)69(4)]TJ /T1_3 1 Tf 25 0 0 25 28.115 56.0378 Tm (90)Tj ET endstream endobj 1632 0 obj <>/Border[0 0 0]/H/N/Rect[262.057 708.512 291.968 699.056]/Subtype/Link/Type/Annot>> endobj 1633 0 obj <>/Border[0 0 0]/H/N/Rect[70.8661 698.512 137.042 689.216]/Subtype/Link/Type/Annot>> endobj 1634 0 obj <>/Border[0 0 0]/H/N/Rect[162.4 648.512 271.568 639.216]/Subtype/Link/Type/Annot>> endobj 1635 0 obj <>/Border[0 0 0]/H/N/Rect[262.057 618.512 291.968 609.056]/Subtype/Link/Type/Annot>> endobj 1636 0 obj <>/Border[0 0 0]/H/N/Rect[70.8661 608.512 115.29 599.216]/Subtype/Link/Type/Annot>> endobj 1637 0 obj <>/Border[0 0 0]/H/N/Rect[167.816 548.512 237.824 539.216]/Subtype/Link/Type/Annot>> endobj 1638 0 obj <>/Border[0 0 0]/H/N/Rect[262.057 508.512 291.968 499.056]/Subtype/Link/Type/Annot>> endobj 1639 0 obj <>/Border[0 0 0]/H/N/Rect[70.8661 498.512 127.162 489.216]/Subtype/Link/Type/Annot>> endobj 1640 0 obj <>/Border[0 0 0]/H/N/Rect[85.6442 448.512 193.892 439.216]/Subtype/Link/Type/Annot>> endobj 1641 0 obj <>/Border[0 0 0]/H/N/Rect[161.766 408.512 258.798 399.216]/Subtype/Link/Type/Annot>> endobj 1642 0 obj <>/Border[0 0 0]/H/N/Rect[164.966 368.512 262.438 359.216]/Subtype/Link/Type/Annot>> endobj 1643 0 obj <>/Border[0 0 0]/H/N/Rect[165.662 318.512 274.83 309.216]/Subtype/Link/Type/Annot>> endobj 1644 0 obj <>/Border[0 0 0]/H/N/Rect[85.6442 278.512 194.812 269.216]/Subtype/Link/Type/Annot>> endobj 1645 0 obj <>/Border[0 0 0]/H/N/Rect[165.662 248.512 256.357 239.216]/Subtype/Link/Type/Annot>> endobj 1646 0 obj <>/Border[0 0 0]/H/N/Rect[85.6442 208.512 168.3 199.216]/Subtype/Link/Type/Annot>> endobj 1647 0 obj <>/Border[0 0 0]/H/N/Rect[162.8 158.512 264.072 149.216]/Subtype/Link/Type/Annot>> endobj 1648 0 obj <>/Border[0 0 0]/H/N/Rect[318.085 728.512 426.765 719.216]/Subtype/Link/Type/Annot>> endobj 1649 0 obj <>/Border[0 0 0]/H/N/Rect[318.085 678.512 402.261 669.216]/Subtype/Link/Type/Annot>> endobj 1650 0 obj <>/Border[0 0 0]/H/N/Rect[494.498 638.512 524.409 629.056]/Subtype/Link/Type/Annot>> endobj 1651 0 obj <>/Border[0 0 0]/H/N/Rect[303.307 628.512 348.371 619.216]/Subtype/Link/Type/Annot>> endobj 1652 0 obj <>/Border[0 0 0]/H/N/Rect[338.503 588.512 437.015 579.216]/Subtype/Link/Type/Annot>> endobj 1653 0 obj <>/Border[0 0 0]/H/N/Rect[494.498 548.512 524.409 539.056]/Subtype/Link/Type/Annot>> endobj 1654 0 obj <>/Border[0 0 0]/H/N/Rect[303.307 538.512 349.747 529.216]/Subtype/Link/Type/Annot>> endobj 1655 0 obj <>/Border[0 0 0]/H/N/Rect[494.498 508.512 524.409 499.056]/Subtype/Link/Type/Annot>> endobj 1656 0 obj <>/Border[0 0 0]/H/N/Rect[303.307 498.512 370.867 489.216]/Subtype/Link/Type/Annot>> endobj 1657 0 obj <>/Border[0 0 0]/H/N/Rect[489.898 468.512 524.409 459.056]/Subtype/Link/Type/Annot>> endobj 1658 0 obj <>/Border[0 0 0]/H/N/Rect[303.307 458.512 360.811 449.216]/Subtype/Link/Type/Annot>> endobj 1659 0 obj <>/Border[0 0 0]/H/N/Rect[494.498 428.512 524.409 419.056]/Subtype/Link/Type/Annot>> endobj 1660 0 obj <>/Border[0 0 0]/H/N/Rect[303.307 418.512 382.075 409.216]/Subtype/Link/Type/Annot>> endobj 1661 0 obj <>/Border[0 0 0]/H/N/Rect[424.821 378.512 511.029 369.056]/Subtype/Link/Type/Annot>> endobj 1662 0 obj <>/Border[0 0 0]/H/N/Rect[318.085 328.512 426.501 319.216]/Subtype/Link/Type/Annot>> endobj 1663 0 obj <>/Border[0 0 0]/H/N/Rect[318.085 288.512 384.093 279.216]/Subtype/Link/Type/Annot>> endobj 1664 0 obj <>/Border[0 0 0]/H/N/Rect[335.219 238.512 462.026 229.216]/Subtype/Link/Type/Annot>> endobj 1665 0 obj <>/Border[0 0 0]/H/N/Rect[342.415 198.512 469.222 189.216]/Subtype/Link/Type/Annot>> endobj 1666 0 obj <>/Border[0 0 0]/H/N/Rect[318.085 148.512 380.749 139.216]/Subtype/Link/Type/Annot>> endobj 1701 0 obj <> endobj 1700 0 obj <> endobj 1699 0 obj <> endobj 1698 0 obj <> endobj 1697 0 obj <> endobj 1696 0 obj <> endobj 1695 0 obj <> endobj 1694 0 obj <> endobj 1693 0 obj <> endobj 1692 0 obj <> endobj 1691 0 obj <> endobj 1690 0 obj <> endobj 1689 0 obj <> endobj 1688 0 obj <> endobj 1687 0 obj <> endobj 1686 0 obj <> endobj 1685 0 obj <> endobj 1684 0 obj <> endobj 1683 0 obj <> endobj 1682 0 obj <> endobj 1681 0 obj <> endobj 1680 0 obj <> endobj 1679 0 obj <> endobj 1678 0 obj <> endobj 1677 0 obj <> endobj 1676 0 obj <> endobj 1675 0 obj <> endobj 1674 0 obj <> endobj 1673 0 obj <> endobj 1672 0 obj <> endobj 1671 0 obj <> endobj 1670 0 obj <> endobj 1669 0 obj <> endobj 1668 0 obj <> endobj 1667 0 obj <> endobj 1628 0 obj [1702 0 R 1703 0 R 1704 0 R 1705 0 R 1706 0 R 1707 0 R] endobj 1629 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\032)30(\002\013\001\006\013\001\013\007\216\001\020\016 \232\001\201\025\024\220\ \n\002\025\207\220\002\215\002\202\220\017\016\006\n\220\016 \r\024\016\ \013\026)11(\016\007\216\006)-10(\026\r\013 )]TJ 0 -1 TD [(\221\002\220\022\002\013\n\016 \221\002\205\024\025\203 \n\220\n\220 \221\ \025\006)-10(\007\016 \007\215\017\016\r\025\203 \220\007\220 )]TJ T* [(\207\220\024\220\025\007\215\017\016\r\025\203 \026)11(\016\002\013\221\220\220\022\236 \001\212\013\001\006\020 \220\022\002\016\ \222)21.1(\215\007\216)21(\026)11(\013\026\020)]TJ 32.955 2 Td [(T)20(r)21(ansanal endoscopic micr)20(osur)31(ger)-31(y af)-31(ter r)21(adiation or ch)11(emor)21(adiation )]TJ 7.251 -1 Td [(th)11(er)21(apy for r)31(ectal cancer\022\236 peculiarities and r)31(esults)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0.303 Tw 10 0 0 10 42.5197 724.8299 Tm (\215\024\004\031\036\r \230\026\030\026\f \215\036\021\030\024\r\017\004\ )Tj /Span<>> BDC ( )Tj EMC (\227 \022\026\027\007\017\007\026\021 \n\036\007\017\006\017\027\f\022\017\ \b )Tj -0.075 Tw 0 -1.218 TD (\027\026\031\022, \f\021\026\030\001\017\005 \027\026\031\004\027\t\005 \ \f\024\021\030\031\007\027\017\022 \024\021\007\036\035\036\027\017\016 \ \035\031\004\036\r\024\020\024 )Tj 0.04 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\b\017\030\031\030\020\017\004\036\f\022\024\020\024 \035\036\004\036\027\ \017\016 \026\002\024\035\036\r\026\027\017\005 \026\002\007\024\n\017\027\ \026\035\034)Tj 0 Tw (-)Tj 0.031 Tw T* (\027\024\005 \024\002\035\026\f\021\017 \204\217\203\037 \017\n\036\027\017\ \202.\205. \037\t\002\026)Tj /Span<>> BDC ( )Tj EMC (\227 \235\017\035\017\026\035 \205\206\207\211 )Tj 0.353 Tw T* [(\253\203\204\222\037 \030\026\007\017\024\035\024\020\017\017\273 \204\017\ \027\007\030\026\r\026 )0.5(\217\024\f\f\017\017, \210\002\027\017\027\f\022; )]TJ 0 Tw T* (SPIN-\022\024\007: 1858-0968; ORCID: 0000-0002-9243-6519)Tj 0.038 Tw 0 -1.218 TD (\204\017\b\026\035\201\r\026 \236\035\017\016 \236\030\034\036\r\027\026\ )Tj /Span<>> BDC ( )Tj EMC (\227 \r\030\026\004-\024\027\022\024\035\024\020 \024\021\007\036\035\036\ \027\017\016 )Tj 0.04 Tw 0 -1.218 TD (\035\031\004\036\r\024\020\024 \017)Tj /Span<>> BDC ( )Tj EMC (\b\017\030\031\030\020\017\004\036\f\022\024\020\024 \035\036\004\036\027\ \017\016 \026\002\024\035\036\r\026\027\017\005 \026\002)Tj 0 Tw (-)Tj 0.03 Tw T* (\007\024\n\017\027\026\035\034\027\024\005 \024\002\035\026\f\021\017 \204\ \217\203\037 \017\n\036\027\017 \202.\205. \037\t\002\026)Tj /Span<>> BDC ( )Tj EMC (\227 \235\017)Tj 0 Tw (-)Tj 0.095 Tw T* (\035\017\026\035\026 \205\206\207\211 \253\203\204\222\037 \030\026\007\017\ \024\035\024\020\017\017\273 \204\017\027\007\030\026\r\026 \217\024\f\f\ \017\017, )Tj 0 Tw T* (\210\002\027\017\027\f\022; ORCID: 0000-0002-9449-2135)Tj 0.158 Tw T* (\207\036\030\036\024\r\f\022\026\016 \230\026\021\034\016\027\026 \215\026\ \r\035\024\r\027\026)Tj /Span<>> BDC ( )Tj EMC (\227 \007\024\022\021\024\030 \n\036\007\017\006\017\027)Tj 0 Tw (-)Tj 0.45 Tw 0 -1.218 TD (\f\022\017\b \027\026\031\022, \023\030\024\235\036\f\f\024\030, \020\035\ \026\r\027\t\005 \027\026\031\004\027\t\005 \f\024\021\030\031\007)Tj 0 Tw (-)Tj 0.334 Tw 0 -1.218 TD (\027\017\022 \024\021\007\036\035\036\027\017\016 \035\031\004\036\r\024\ \005 \007\017\026\020\027\024\f\021\017\022\017 \204\217\203\037 \017\n\036\ \027\017 )Tj 0.285 Tw 0 -1.218 TD (\202.\205. \037\t\002\026)Tj /Span<>> BDC ( )Tj EMC (\227 \235\017\035\017\026\035\026 \205\206\207\211 \253\203\204\222\037 \ \030\026\007\017\024\035\024\020\017\017\273 )Tj 0.259 Tw T* (\204\017\027\007\030\026\r\026 \217\024\f\f\017\017, \210\002\027\017\027\ \f\022; SPIN-\022\024\007: 5837-3465; )Tj 0 Tw T* (ORCID: 0000-0002-3549-4499)Tj 0.139 Tw T* (\003\017\002\017\030\024\r \217\031\f\035\026\027 \205\016\030\017\021\024\ \r\017\004)Tj /Span<>> BDC ( )Tj EMC (\227 \r\030\026\004-\023\026\021\024\035\024\020\024\026\027\026\021\024\ \n )Tj 0.615 Tw T* (\023\026\021\024\035\024\020\024\026\027\026\021\024\n\017\004\036\f\022\ \024\020\024 \024\021\007\036\035\036\027\017\016 \204\217\203\037 \017\n\ \036\027\017 )Tj 0.285 Tw T* (\202.\205. \037\t\002\026)Tj /Span<>> BDC ( )Tj EMC (\227 \235\017\035\017\026\035\026 \205\206\207\211 \253\203\204\222\037 \ \030\026\007\017\024\035\024\020\017\017\273 )Tj 0.259 Tw T* (\204\017\027\007\030\026\r\026 \217\024\f\f\017\017, \210\002\027\017\027\ \f\022; SPIN-\022\024\007: 6704-9766; )Tj 0 Tw T* (ORCID: 0000-0001-5252-0436.)Tj 0.035 Tw T* (\204\016\035\017\027\026 \221\024\235\017\016 \202\027\026\021\024\035\034\ \036\r\027\026)Tj /Span<>> BDC ( )Tj EMC (\227 \n\035\026\007\001\017\005 \027\026\031\004\027\t\005 \f\024)Tj 0 Tw (-)Tj 0.134 Tw T* (\021\030\031\007\027\017\022, \r\030\026\004-\030\036\027\021\020\036\027\ \024\035\024\020 \024\021\007\036\035\036\027\017\016 \035\031\004\036\r\ \024\005 \007\017\026\020)Tj 0 Tw (-)Tj 0.215 Tw T* (\027\024\f\021\017\022\017 \204\217\203\037 \017\n\036\027\017 \202.\205\ . \037\t\002\026)Tj /Span<>> BDC ( )Tj EMC (\227 \235\017\035\017\026\035\026 \205\206\207\211 )Tj 0.353 Tw T* [(\253\203\204\222\037 \030\026\007\017\024\035\024\020\017\017\273 \204\017\ \027\007\030\026\r\026 )0.5(\217\024\f\f\017\017, \210\002\027\017\027\f\022; )]TJ 0 Tw T* (ORCID: 0000-0002-4524-0839)Tj -0.037 Tw T* (\210\030\036\b\024\r \222\r\026\027 \202\027\026\021\024\035\034\036\r\017\ \004)Tj /Span<>> BDC ( )Tj EMC (\227 \r\030\026\004-\024\027\022\024\035\024\020 \024\021\007\036\035\036\ \027\017\016 )Tj 0.04 Tw T* (\035\031\004\036\r\024\020\024 \017)Tj /Span<>> BDC ( )Tj EMC (\b\017\030\031\030\020\017\004\036\f\022\024\020\024 \035\036\004\036\027\ \017\016 \026\002\024\035\036\r\026\027\017\005 \026\002)Tj 0 Tw (-)Tj 0.03 Tw T* (\007\024\n\017\027\026\035\034\027\024\005 \024\002\035\026\f\021\017 \204\ \217\203\037 \017\n\036\027\017 \202.\205. \037\t\002\026)Tj /Span<>> BDC ( )Tj EMC (\227 \235\017)Tj 0 Tw (-)Tj 0.095 Tw T* (\035\017\026\035\026 \205\206\207\211 \253\203\204\222\037 \030\026\007\017\ \024\035\024\020\017\017\273 \204\017\027\007\030\026\r\026 \217\024\f\f\ \017\017, )Tj 0 Tw T* (\210\002\027\017\027\f\022)Tj 0.478 Tw T* (\215\036\021\030\024\r \214\036\024\027\017\007 \210\035\036\020\024\r\017\ \004)Tj /Span<>> BDC ( )Tj EMC (\227 \022\026\027\007\017\007\026\021 \n\036\007\017\006\017\027)Tj 0 Tw (-)Tj 0.886 Tw T* [(\f\022\017\b \027\026\031\022, \026\r\036\007\031\033\013\017\005 )0.5(\024\021\007\036\035\036\027\017\036\n \035\031\004\036\r\024\020\024 )]TJ 0.04 Tw 23.244 40.187 Td (\017)Tj /Span<>> BDC ( )Tj EMC (\b\017\030\031\030\020\017\004\036\f\022\024\020\024 \035\036\004\036\027\ \017\016 \026\002\024\035\036\r\026\027\017\005 \026\002\007\024\n\017\027\ \026\035\034)Tj 0 Tw (-)Tj -0.026 Tw T* [(\027\024\005 )0.6(\024\002\035\026\f\021\017 )0.6(\204\217\203\037 )0.6(\017\n\036\027\017 )0.6(\202.\205. )0.6(\037\t\002\026)]TJ /Span<>> BDC ( )Tj EMC 15.001 0 Td [(\227 )0.6(\235\017\035\017\026\035\026 )0.6(\205\206\207\211 )]TJ 0.353 Tw -15.001 -1.218 Td [(\253\203\204\222\037 \030\026\007\017\024\035\024\020\017\017\273 \204\017\ \027\007\030\026\r\026 )0.5(\217\024\f\f\017\017, \210\002\027\017\027\f\022; )]TJ 0 Tw T* (SPIN-\022\024\007: 4559-3613)Tj 0.114 Tw T* (\222\r\026\027\024\r \221\036\030\020\036\005 \202\027\026\021\024\035\034\ \036\r\017\004)Tj /Span<>> BDC ( )Tj EMC (\227 \007\024\022\021\024\030 \n\036\007\017\006\017\027\f\022\017\b )Tj 0.076 Tw T* (\027\026\031\022, \004\035\036\027-\022\024\030\030\036\f\023\024\027\007\ \036\027\021 \217\202\203, \007\017\030\036\022\021\024\030 \204\217\203\ \037 \017\n\036)Tj 0 Tw (-)Tj 0.064 Tw 0 -1.218 TD (\027\017 \202.\205. \037\t\002\026)Tj /Span<>> BDC ( )Tj EMC (\227 \235\017\035\017\026\035\026 \205\206\207\211 \253\203\204\222\037 \ \030\026\007\017\024\035\024\020\017\017\273 )Tj 0.018 Tw 0 -1.218 TD (\204\017\027\007\030\026\r\026 \217\024\f\f\017\017, \210\002\027\017\027\ \f\022, \023\030\024\235\036\f\f\024\030 \022\026\235\036\007\030\t \024\ \027)Tj 0 Tw (-)Tj 0.068 Tw T* (\022\024\035\024\020\017\017 \017)Tj /Span<>> BDC ( )Tj EMC (\030\036\027\021\020\036\027\024\030\026\007\017\024\035\024\020\017\017\ \017\n\036\027\017 \200.\215. \216\026\030\004\036\027\022\024 )Tj 0.385 Tw T* (\n\036\007\017\006\017\027\f\022\024\020\024 \017\027\f\021\017\021\031\021\ \026 \217\211\212\203, \204\024\f\022\r\026; SPIN-\022\024\007: )Tj 0 Tw T* (4264-5167; ORCID: 0000-0001-7689-6032)Tj 0.109 Tw T* (\025\026\023\030\017\027 \202\027\007\030\036\005 \212\n\017\021\030\017\ \036\r\017\004)Tj /Span<>> BDC ( )Tj EMC (\227 \007\024\022\021\024\030 \n\036\007\017\006\017\027\f\022\017\b )Tj 0.094 Tw 0 -1.218 TD (\027\026\031\022, \023\030\024\235\036\f\f\024\030, \026\022\026\007\036\ \n\017\022 \217\202\203, \026\022\026\007\036\n\017\022 \217\202\210, \004\ \035\036\027 )Tj -0.006 Tw 0 -1.218 TD (\215\030\036\017\007\017\031\n\026 \217\202\203, \004\035\036\027 \215\030\ \036\017\007\017\031\n\026 \217\202\210 \003\026\f\035\031\032\036\027\027\ \t\005 )Tj 0.018 Tw 0 -1.218 TD [(\r\030\026\004 \217\024\f\f\017\017, \020\036\027\036\030\026\035\034\027\ \t\005 )0.5(\007\017\030\036\022\021\024\030 )0.5(\205\206\207\211 \253\203\204\222\037 )0.5(\030\026)]TJ 0 Tw (-)Tj 0.084 Tw T* [(\007\017\024\035\024\020\017\017\273 \204\017\027\007\030\026\r\026 \217\ \024\f\f\017\017, )0.5(\210\002\027\017\027\f\022, \026\r\036\007\031\033\013\017\005 )]TJ 0.271 Tw T* (\022\026\235\036\007\030\024\005 \024\027\022\024\035\024\020\017\017 \017\ )Tj /Span<>> BDC ( )Tj EMC (\030\036\027\021\020\036\027\024\030\026\007\017\024\035\024\020\017\017\ \017\n\036\027\017 )Tj 0.033 Tw T* (\200.\215. \216\026\030\004\036\027\022\024 \n\036\007\017\006\017\027\f\ \022\024\020\024 \017\027\f\021\017\021\031\021\026 \217\211\212\203; OR\ CID: )Tj 0 Tw T* (0000-0001-8784-8415)Tj /T1_2 1 Tf 0.023 Tw 0 -2.436 TD (INFORMATION ABOUT THE AUTHORS \(ORCID\))Tj /T1_1 1 Tf 0 Tw 0 -1.218 TD [(Alek)-10(se)-10.9(y A. Nevolsk)-15.9(ikh)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0001-5961-2958)Tj T* [(Ale)-18(x)-10.9(ander R. Br)-31.9(odsk)-16(iy)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0002-4709-1726)Tj T* [(V)-15(iole)-12(t)-30(t)15.1(a A. A)15(v)12(deenko)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0002-2678-016X)Tj T* [(T)40(ar)-33(as P. P)10.1(o)-16(chuev)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0002-9243-6519)Tj T* [(Y)35(ul)-31(ia Y)35.1(u. Mihalev)-15(a)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0002-9449-2135)Tj T* [(T)40(a)15(t)-32(iana P. Ber)-23.9(ezovsk)-16.9(a)15(y)22(a)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0002-3549-4499)Tj T* [(Rusl)-16(an F. Z)-15.9(ibir)-32(ov)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0001-5252-0436)Tj T* [(S)-16(o\237a A. M)16.1(y)22(al)-31(ina)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0002-4524-0839)Tj T* [(Iv)-15(an A. Or)-23.9(ehov)]TJ T* [(L)35(eonid O. P)30.1(e)-12(tr)-32(ov)]TJ /Span<>> BDC ( )Tj EMC (\227 SPIN code: 4559-3613)Tj T* [(Ser)-32(ge)-11(y A. Iv)-14.9(anov)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0001-7689-6032)Tj T* [(Andr)-24(e)-10.9(y D. K)-16(ap)25(r)-37(in)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0001-8784-8415)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 42.5896 286.4219 Tm [(\r\031\024\034\033)48(\026)45(\024)-10(\223\033)48(\026/REFERENCES)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0 Tc 0.038 Tw 8 0 0 8 42.5197 273.5872 Tm (1.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (\025\026\023\030\017\027)Tj /Span<>> BDC ( )Tj EMC [(\202.\212., )0.5(\221\021\026\030\017\027\f\022\017\005)]TJ /Span<>> BDC ( )Tj EMC 10.568 0 Td (\200.\200., \234\026\b\026\007\024\r\026)Tj /Span<>> BDC ( )Tj EMC [(\202.\210. \221\024\f\021\024\016\027\017\036 )0.5(\024\027\022\024)]TJ 0 Tw (-)Tj 0.178 Tw -11.864 -1.25 Td (\035\024\020\017\004\036\f\022\024\005 \023\024\n\024\013\017 \027\026\f\ \036\035\036\027\017\033 \217\024\f\f\017\017 \r)Tj /Span<>> BDC ( )Tj EMC (2022 \020\024\007\031. \204.: \204\203\222\210\222 )Tj 0.026 Tw 0 -1.25 TD (\017\n. \215.\202. \206\036\030\006\036\027\026)Tj /Span<>> BDC ( )Tj EMC [(\227 \235\017\035\017\026\035 \205\206\207\211 \253\203\204\222\037 \030\ \026\007\017\024\035\024\020\017\017\273 )0.5(\204\017\027\007\030\026\r\026 )]TJ -0.008 Tw T* [(\217\024\f\f\017\017. 2022. ISBN 978-5-85502-283-4 / K)-16(ap)25(r)-37(in)]TJ /Span<>> BDC ( )Tj EMC [(A.D., S)15(t)15(ar)-36.9(insk)-32(y)]TJ /Span<>> BDC ( )Tj EMC (V.V., )Tj 0.159 Tw T* [(S)-16(hakhzad)-15.9(ov)-15(a)]TJ /Span<>> BDC ( )Tj EMC 5.638 0 Td [(A.O. )0.6(T)47(he )0.5(st)15(a)15(te )0.6(of )0.5(oncol)30(o)-15.9(gical )0.5(car)-23.9(e )0.5(t)17(o )0.5(t)-12.9(he )0.5(popul)-16(a)15(t)-31.9(ion )]TJ 0.121 Tw -5.638 -1.25 Td [(of Russia in 2022. M.: P.A. Her)-24(zen M)-24(osco)-13.9(w S)14.9(t)15.1(a)15(te Medical R)13(esear)-32(ch )]TJ -0.026 Tw T* [(Inst)-32(i)-23.9(tute)]TJ /Span<>> BDC ( )Tj EMC 3.864 0 Td [(\227 )0.5(Br)-32.9(anch )0.5(of )0.5(t)-12.9(he )0.5(F)10(eder)-33(al )0.6(S)15(t)15(a)15(te )0.5(Budge)-11.9(t)15(ar)-24(y )0.5(Inst)-31.9(i)-24(tut)-32(ion )0.6(\231NMIC )]TJ 0.099 Tw -3.864 -1.25 Td [(of R)-10(adiol)30.1(o)-16(g)16(y\232 of t)-13(he Ministr)-23.9(y of Heal)56(t)-13(h of Russia. 2022. \(in Russ.\). )]TJ 0.023 Tw T* (ISBN 978-5-85502-283-4.)Tj 0.018 Tc 0.647 Tw T* (2.)Tj /Span<>> BDC ( )Tj EMC 1.349 0 Td [(\204\017\027\017\f\021\036\030\f\021\r\024 \003\007\030\026\r\024\024\b\030\ \026\027\036\027\017\016 \217\024\f\f\017\005\f\022\024\005 \205\036\007\ \036\030\026\006\017\017.)18( )]TJ 0 Tc 0.318 Tw -1.349 -1.25 Td [(\025\035\017\027\017\004\036\f\022\017\036 )0.5(\030\036\022\024\n\036\027\007\026\006\017\017. \217\026\022 \023\030\016\ \n\024\005 \022\017\001\022\017. [\224\035\036\022\021\030\024\027\027\t\ \005 )]TJ 0.297 Tw T* [(\030\036\f\031\030\f]. \217\031\002\030\017\022\026\021\024\030 \022\035\ \017\027\017\004\036\f\022\017\b \030\036\022\024\n\036\027\007\026\006\017\ \005. URL: ht)-29.9(tps://)]TJ 0.009 Tc 0.349 Tw T* [(cr.minzdr)-32.7(av.gov.r)-21.6(u/schema/554_2. / Ministr)-23.7(y of Heal)56.3(t)-12.7(h of t)-12.7(he)9( )]TJ 0 Tc 0.053 Tw T* [(Russian F)10(eder)-32.9(a)15(t)-32(ion. Cl)-31(inical r)-24(ecommend)42(a)15(t)-32(ions. R)13(ec)-16(t)15(al cancer. [elec)]TJ 0 Tw (-)Tj 0.008 Tw T* [(tr)-32(onic r)-24(esour)-32(ce]. Rubr)-37(ica)15(t)17(or of cl)-31(inical r)-24(ecommend)42(a)15(t)-32(ions. \(in Russ.\). )]TJ 0.023 Tw T* [(URL: ht)-29.9(tps://cr.minzdr)-32.9(av.gov.r)-22(u/schema/554_2.)]TJ 0.096 Tw T* (3.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Da)15(t)-30(t)15(ani)]TJ /Span<>> BDC ( )Tj EMC (M, Heald)Tj /Span<>> BDC ( )Tj EMC (RJ, Goussous)Tj /Span<>> BDC ( )Tj EMC [(G, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Oncol)30(o)-16(gical and Sur)-31.9(v)-16(i)-16(v)-15(al )]TJ 0.295 Tw -1.296 -1.25 Td [(Outcomes in W)12(a)15.1(tch and W)12.1(ai)-24(t P)40(a)15(t)-32(ients W)-16(i)-23.9(t)-13(h a Cl)-31(inical Com)10(ple)-11.9(te )]TJ 0.018 Tc 0.635 Tw T* [(R)13.5(e)0.5(s)0.5(p)0.5(o)0.5(n)0.6(s)0.5(e)0.5( A)0.6(f)-27.5(t)0.5(e)0.5(r)0.5( N)0.5(e)0.5(o)0.5(a)0.5(d)17.5(j)0.6(u)0.5(v)-14.5(a)0.5(n)0.5(t)0.5( C)0.5(h)0.5(e)0.5(m)0.5(o)0.6(r)-32.5(a)0.5(d)0.5(i)0.5(o)17.5(t)-12.5(h)0.6(e)0.5(r)-32.5(a)0.5(p)0.5(y)0.5( f)0.5(o)0.5(r)0.5( R)13.5(e)0.5(c)-15.5(t)15.6(al)18.1( )]TJ 0 Tc 0 Tw T* (Cancer. )Tj /T1_4 1 Tf 0.219 Tw 3.416 0 Td [(A Systematic R)21(evie)10(w and P)15(ooled Analysis. Ann Surg. )]TJ /T1_1 1 Tf 0 Tw (2018 )Tj 0.023 Tw 25.639 23.75 Td [(Dec;268\(6\):955\226967. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw [(10.1097/SL)-35(A.0000000000002761)]TJ 0 0 0 1 k /GS1 gs 0.009 Tc 0.349 Tw T* (4.)Tj /Span<>> BDC ( )Tj EMC 1.322 0 Td [(v)-14.7(an der V)25.2(alk)]TJ /Span<>> BDC ( )Tj EMC [(MJM, Hill)-30.7(ing)]TJ /Span<>> BDC ( )Tj EMC [(DE, Bast)-31.8(iaanne)-11.7(t)]TJ /Span<>> BDC ( )Tj EMC [(E, e)-11.7(t)]TJ /Span<>> BDC ( )Tj EMC [(al. IWWD)9( )]TJ 0 Tc 0.236 Tw -1.322 -1.25 Td [(Consor)-22(t)-31.9(ium. L)35.1(ong-ter)-16(m )0.5(outcomes )0.5(of )0.5(cl)-31(inical )0.5(com)10(ple)-12(te )0.5(r)-24(esponder)-9.9(s )]TJ 0.143 Tw T* [(af)-28(ter neoad)17.1(juv)-15(ant tr)-24(ea)15.1(tment for r)-24(ec)-15.9(t)15(al cancer in t)-12.9(he Inter)-15(na)15(t)-32(ional )]TJ -0.023 Tw T* [(W)12(a)15(tch & W)12(ai)-23.9(t Da)15(t)15.1(abase \(IWWD\): an inter)-15(na)15(t)-32(ional mul)56(t)-32(icentr)-23.9(e r)-24(egistr)-24(y )]TJ 0 Tw T* [(stud)17(y. )]TJ /T1_4 1 Tf 2.86 0 Td (Lancet)Tj /T1_1 1 Tf 0.144 Tw [(. 2018 Jun 23;391\(10139\):2537\2262545. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1016/)Tj -2.86 -1.25 Td (S0140-6736\(18\)31078-X)Tj 0 0 0 1 k /GS1 gs 0.3 Tw T* (5.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Cer)-24(d)42(an-Sant)15.1(a)-17(cr)-22(uz)]TJ /Span<>> BDC ( )Tj EMC [(C, V)25(ail)-16(a)15.1(t)-32(i)]TJ /Span<>> BDC ( )Tj EMC [(BB, Jul)-31(iao)]TJ /Span<>> BDC ( )Tj EMC [(GPS, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. W)12(a)15(tch and )]TJ 0.151 Tw -1.296 -1.25 Td [(w)-12(ai)-24(t: )0.6(Why, )0.6(t)17(o )0.5(whom )0.6(and )0.5(ho)-14(w. )]TJ /T1_4 1 Tf 12.856 0 Td [(Surgical )0.6(Oncology)]TJ /T1_1 1 Tf [(. )0.5(2022 )0.6(43-101774. )]TJ 0 Tw -12.856 -1.25 Td [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td [(10.1016/j.sur)-31.9(onc.2022.101774)]TJ 0 0 0 1 k /GS1 gs 0.193 Tw -1.847 -1.25 Td (6.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(F)10(ok)-17(as)]TJ /Span<>> BDC ( )Tj EMC [(E, S)-24(chlensk)-17(a-L)-31.9(ange)]TJ /Span<>> BDC ( )Tj EMC [(A, P)10(ol)-15.9(a)15(t)]TJ /Span<>> BDC ( )Tj EMC [(B, e)-11.9(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Chemor)-32.9(adio)17(t)-13(her)-33(apy )]TJ 0.044 Tw -1.296 -1.25 Td [(Pl)35(us )0.6(Induc)-16(t)-32(ion )0.6(or )0.6(Consol)-31(id)42(a)15(t)-32(ion )0.6(Chemo)17(t)-13(her)-32.9(apy )0.5(as )0.6(T)45(o)17(t)15(al )0.6(Neoad)17(juv)-15(ant )]TJ 0.001 Tw T* [(T)47(her)-33(apy for P)40(a)15(t)-32(ients W)-16(i)-24(t)-13(h L)35(o)-16(call)35.1(y A)15.1(d)-17(v)-15(anced R)13(ec)-16(t)15(al Cancer: L)35(ong-ter)-15.9(m )]TJ 0.286 Tw T* [(R)13(esul)56(ts of t)-13(he C)20(A)15(O/ARO/AIO-12 R)-10(and)-16(omized Cl)-31(inical T)50(r)-37(ial. )]TJ /T1_4 1 Tf 0 Tw [(J)30(AMA )]TJ T* (Oncol)Tj /T1_1 1 Tf -0.019 Tw [(. 2022 Jan 1;8\(1\):e215445. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1001/jamaoncol.2021.5445)Tj 0 0 0 1 k /GS1 gs 0.14 Tw T* (7.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Gar)-32(c)-23.9(ia-A)-25(guil)-16(ar)]TJ /Span<>> BDC ( )Tj EMC 6.203 0 Td [(J, )0.5(R)13(enfr)-31.9(o)]TJ /Span<>> BDC ( )Tj EMC 4.043 0 Td [(L)-35(A, )0.6(Cho)-14(w)]TJ /Span<>> BDC ( )Tj EMC 4.093 0 Td [(OS, )0.5(e)-12(t)]TJ /Span<>> BDC ( )Tj EMC 2.78 0 Td [(al. )0.6(Or)-32(gan )0.5(p)25(r)-24(eser)-31.9(v)-15(a)15(t)-32(ion )]TJ 0.017 Tw -18.415 -1.25 Td [(for cl)-30.9(inical T2N0 dist)15(al r)-23.9(ec)-16(t)15(al cancer using neoad)17(juv)-15(ant chemor)-32.9(adio)]TJ 0 Tw (-)Tj 0.017 Tw T* [(t)-13(her)-32.9(apy and l)30(o)-16(cal e)-17.9(x)-13(c)-24(ision \(A)16(C)13(OSOG Z6041\): r)-24(esul)56.1(ts of an open-l)-15.9(abel, )]TJ 0.267 Tw T* [(single-ar)-15.9(m, mul)56(t)-32(i-inst)-32(i)-24(tut)-32(ional, phase 2 tr)-37(ial. )]TJ /T1_4 1 Tf (Lancet Oncol.)Tj /T1_1 1 Tf ( 2015 )Tj 0.023 Tw T* [(N)-14(ov;16\(15\):1537\2261546. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1016/S1470-2045\(15\)00215-6)Tj /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\033\030\031\030\213\b)-20.9(\035\231\213\233\t \021\032)50(\b)42(\032\231\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj /T1_5 1 Tf 25 0 0 25 512.8644 56.0378 Tm (89)Tj ET endstream endobj 1702 0 obj <>/Border[0 0 0]/H/N/Rect[361.061 280.883 469.308 271.587]/Subtype/Link/Type/Annot>> endobj 1703 0 obj <>/Border[0 0 0]/H/N/Rect[466.151 230.883 496.063 221.427]/Subtype/Link/Type/Annot>> endobj 1704 0 obj <>/Border[0 0 0]/H/N/Rect[274.961 220.883 354.064 211.587]/Subtype/Link/Type/Annot>> endobj 1705 0 obj <>/Border[0 0 0]/H/N/Rect[289.739 190.883 390.666 181.587]/Subtype/Link/Type/Annot>> endobj 1706 0 obj <>/Border[0 0 0]/H/N/Rect[396.288 140.883 496.063 131.427]/Subtype/Link/Type/Annot>> endobj 1707 0 obj <>/Border[0 0 0]/H/N/Rect[369.756 90.8833 478.924 81.5872]/Subtype/Link/Type/Annot>> endobj 1713 0 obj <> endobj 1712 0 obj <> endobj 1711 0 obj <> endobj 1710 0 obj <> endobj 1709 0 obj <> endobj 1708 0 obj <> endobj 1627 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 0 0 0 1 k /GS1 gs /T1_0 1 Tf -0.007 Tw 10 0 0 10 70.8661 724.8299 Tm (\027\036\002\035\026\020\024\023\030\017\016\021\027\t\n \024\021\007\026\ \035\036\027\027\t\n \030\036\031\035\034\021\026\021\026\n \023\030\017\ )Tj /Span<>> BDC ( )Tj EMC (\027\026\035\017)Tj 0 Tw (-)Tj 0 -1.218 TD (\004\017\017 ypT2 \022\026\021\036\020\024\030\017\017 \024\023\031\b\024\ \035\017.)Tj 0.825 Tw T* [(\200 )0.5(\030\026\027\007\024\n\017\017\030\024\r\026\027\027\024\n )0.5(\017\f\f\035\036\007\024\r\026\027\017\017 )0.6(GRECC)20(AR2 )]TJ -0.001 Tw T* (\031)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\034\027\t\b \f)Tj /Span<>> BDC ( )Tj EMC (cT2-3N0-1 \024\023\031\b\024\035\016\n\017 \017)Tj /Span<>> BDC ( )Tj EMC (\b\024\030\024\001\017\n \024\021\r\036\021\024\n )Tj 0.094 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC (\216\214\230 81 \023\026\006\017\036\027\021\031 \002\t\035\017 \r\t\023\ \024\035\027\036\027\t \230\224\204. \215\030\017)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\n )Tj 0.129 Tw T* (\031)Tj /Span<>> BDC ( )Tj EMC (44 \(54%\) \002\t\035\017 \r\t\016\r\035\036\027\t \f\021\026\007\017\017\ ypT0-1. \204\036\f\021\027\t\036 )Tj 0.119 Tw 0 -1.218 TD (\030\036\006\017\007\017\r\t \031\f\021\026\027\024\r\035\036\027\t \031\ )Tj /Span<>> BDC ( )Tj EMC (9% \017)Tj /Span<>> BDC ( )Tj EMC (\024\021\007\026\035\036\027\027\t\036 \n\036\021\026\f\021\026)Tj 0 Tw (-)Tj 0.227 Tw 0 -1.218 TD (\t \031)Tj /Span<>> BDC ( )Tj EMC (14%, \026)Tj /Span<>> BDC ( )Tj EMC (5-\035\036\021\027\016\016 \024\002\013\026\016 \017)Tj /Span<>> BDC ( )Tj EMC (\002\036\030\036\006\017\007\017\r\027\026\016 \r\t)Tj 0 Tw (-)Tj 0.18 Tw T* (\032\017\r\026\036\n\024\f\021\034 \f\024\f\021\026\r\017\035\017 82% \017\ )Tj /Span<>> BDC ( )Tj EMC (70%, \f\024\024\021\r\036\021\f\021\r\036\027\027\024. )Tj 0.269 Tw T* (\003\026\r\036\030\001\026\033\013\017\036 \230\204\224 \002\t\035\017 \r\ \t\023\024\035\027\036\027\t 27 \023\026\006\017\036\027\021\026\n )Tj 0.167 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC [(ypT2-3 \022\026\021\036\020\024\030\017\036\005 )0.5(\024\023\031\b\024\035\017. )0.5(\210\007\027\026\022\024 \026\r\021\024\030\t )0.5(\024\021\n\036)]TJ 0 Tw (-)Tj 0.244 Tw T* (\004\026\033\021, \004\021\024, \031\004\017\021\t\r\026\016 \027\036\002\ \024\035\034\001\024\005 \030\026\n\036\030 \024\f\021\026\021\024\004\027\ \024\005 )Tj 0.076 Tw 0 -1.218 TD [(\024\023\031\b\024\035\017 )0.6(\031)]TJ /Span<>> BDC ( )Tj EMC 4.445 0 Td [(\023\026\006\017\036\027\021\024\r )0.6(\f)]TJ /Span<>> BDC ( )Tj EMC 5.376 0 Td [(\022\026\021\036\020\024\030\017\036\005 )0.6(\024\023\031\b\024\035\017 )0.5(ypT2, )0.5(\026)]TJ 0 Tw (-)Tj -9.821 -1.218 Td (\r\036\030\001\026\033\013\026\016 \230\204\224 \031)Tj /Span<>> BDC ( )Tj EMC (\027\017\b \n\024\032\036\021 \002\t\021\034 \027\036\024\023\030\026\r\007\ \026\027\027\024\005.)Tj 0.269 Tw 0 -1.218 TD (\207\036\030\036\006\017\007\017\r\027\026\016 \021\030\036\b\035\036\021\ \027\016\016 \r\t\032\017\r\026\036\n\024\f\021\034 \r)Tj /Span<>> BDC ( )Tj EMC (\027\026\001\036\n )Tj 0.142 Tw T* [(\017\f\f\035\036\007\024\r\026\027\017\017 )0.6(\f\024\f\021\026\r\017\035\026 )0.5(80,4)]TJ /Span<>> BDC ( )Tj EMC 12.768 0 Td (\261)Tj /Span<>> BDC ( )Tj EMC 0.874 0 Td [(10,4%, )0.5(\004\021\024, )0.6(\r)]TJ /Span<>> BDC ( )Tj EMC 5.761 0 Td (\006\036\035\024\n, )Tj 0.784 Tw -19.404 -1.218 Td [(\f\024\024\021\r\036\021\f\021\r\031\036\021 )0.6(\007\026\027\027\t\n )0.5(\035\017\021\036\030\026\021\031\030\t )0.5(\(75,0\22686,9%\) )]TJ 0.051 Tw T* ([12\22616]. \215\030\017)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\n \023\024\022\026\026\021\036\035\034 \024\002\013\036\005\ \021\030\036\b\035\036\021\027\036\005 \r\t)Tj 0 Tw (-)Tj 0.343 Tw T* [(\032\017\r\026\036\n\024\f\021\017 )0.6(\023\030\036\007\f\021\026\r\035\016\036\021\f\016 )0.5(\024\021\027\024\f\017\021\036\035\034\027\024 )0.6(\027\036\r\t\f\024)]TJ 0 Tw (-)Tj 0.059 Tw T* (\022\017\n)Tj /Span<>> BDC ( )Tj EMC (\227 83,3)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC [(10,8% )0.5(\r\r\017\007\031 \f\n\036\030\021\017 \023\026\006\017\036\027\021\024\r\ )0.5(\024\021 \022\024\027)]TJ 0 Tw (-)Tj T* (\022\031\030\017\030\031\033\013\017\b \026\002\024\035\036\r\026\027\017\ \005.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 70.936 444.7358 Tm [(\020)21(\026\027\r\242\224\034\022\031\034)]TJ 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0 Tc 0.438 Tw 10 0 0 10 70.8661 420.3798 Tm (\221\035\036\007\031\036\021 \f\022\026\026\021\034, \004\021\024 \027\026\ \001 \024\023\t\021 \023\030\017\n\036\027\036\027\017\016 \230\224\204 \ )Tj 0.22 Tw T* (\031)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\034\027\t\b \217\215\025 \023\024\f\035\036 \214\230/\216\214\ \230 \023\024\022\026\026\035, \004\021\024 \007\026\027\027\t\005 )Tj 0.224 Tw T* [(\n\036\021\024\007 )0.5(\n\024\032\027\024 )0.5(\f\004\017\021\026\021\034 )0.6(\220\235\235\036\022\021\017\r\027\t\n )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 16.815 0 Td (\002\036\024\023\026\f\027\t\n. )Tj 0.532 Tw -16.815 -1.218 Td (\200\t\032\017\r\026\036\n\024\f\021\034 \002\036 \f\021\024\n\t \f\024\ \f\021\026\r\017\035\026 92,9%, \004\021\024, )Tj 0.065 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC (\027\026\001 \r\020\035\016\007, \016\r\035\016\036\021\f\016 \b\024\030\ \024\001\017\n \030\036\031\035\034\021\026\021\024\n. \211)Tj /Span<>> BDC ( )Tj EMC (\023\026)Tj 0 Tw (-)Tj 0.041 Tw T* (\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (cCR \035\024\022\026\035\034\027\024\036 \017\f\f\036\004\036\027\017\036\ \024\023\031\b\024\035\017 \f)Tj /Span<>> BDC ( )Tj EMC (\006\036\035\034\033 )Tj 0.508 Tw T* (\023\024\007\021\r\036\030\032\007\036\027\017\016 \023\024\035\027\024\020\ \024 \024\021\r\036\021\026 \027\036\006\036\035\036\f\024\024\002\030\026\ \027\024, )Tj 0.21 Tw T* (\027\036\f\036\021 \r)Tj /Span<>> BDC ( )Tj EMC (\f\036\002\036 \035\017\001\027\017\005 \030\017\f\022 \023\024\f\035\036\ \024\023\036\030\026\006\017\024\027\027\t\b \024\f)Tj 0 Tw (-)Tj 0.133 Tw T* [(\035\024\032\027\036\027\017\005, )0.5(\r\024\n\024\032\027\t\b )0.5(\235\031\027\022\006\017\024\027\026\035\034\027\t\b )0.6(\027\026\030\031\001\036\027\017\005. )]TJ 0.244 Tw T* (\200\024\n\024\032\027\024\f\021\034 \017)Tj /Span<>> BDC ( )Tj EMC (\006\036\035\036\f\024\024\002\030\026\027\024\f\021\034 \023\030\017\n\ \036\027\036\027\017\016 \021\026\022)Tj 0 Tw (-)Tj 0.262 Tw T* (\021\017\022\017 \026\022\021\017\r\027\024\020\024 \007\017\027\026\n\017\ \004\036\f\022\024\020\024 \027\026\002\035\033\007\036\027\017\016 \026\ )Tj /Span<>> BDC ( )Tj EMC (\023\026)Tj 0 Tw (-)Tj 0.277 Tw T* (\006\017\036\027\021\026\n\017 \f)Tj /Span<>> BDC ( )Tj EMC (cCR \r)Tj /Span<>> BDC ( )Tj EMC (\027\026\f\021\024\016\013\036\036 \r\030\036\n\016 \023\024\007\021\r\036\ \030\032\007\036\027\026 )Tj 0.067 Tw T* (\n\027\024\020\024\004\017\f\035\036\027\027\t\n\017 \017\f\f\035\036\007\ \024\r\026\027\017\016\n\017 \017)Tj /Span<>> BDC ( )Tj EMC (\n\036\021\026\026\027\026\035\017\026\n\017 )Tj 0.188 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC [(\026\022\030\036\023\035\036\027\026 \030\024\f\f\017\005\f\022\017\n\017\ )0.5(\022\035\017\027\017\004\036\f\022\017\n\017 \030\036\022\024\n\036\027)]TJ 0 Tw (-)Tj T* (\007\026\006\017\016\n\017 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\217\215\025.)Tj 0.059 Tw T* (\200\n\036\f\021\036 \f)Tj /Span<>> BDC ( )Tj EMC [(\021\036\n, \021\026\022\021\017\022\026 )0.5(\035\036\004\036\027\017\016 \023\026\006\017\036\027\021\024\r )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC (nCR \r)Tj /Span<>> BDC ( )Tj EMC (\027\026)Tj 0 Tw (-)Tj -0.093 Tw T* (\f\021\024\016\013\036\036 \r\030\036\n\016 \024\022\024\027\004\026\021\ \036\035\034\027\024 \027\036 \024\023\030\036\007\036\035\036\027\026. \ \221\024\020\035\026\f\027\024 )Tj 0.624 Tw T* (\022\035\017\027\017\004\036\f\022\017\n \030\036\022\024\n\036\027\007\026\ \006\017\016\n \204\017\027\007\030\026\r\026 \217\024\f\f\017\017, )Tj 0.069 Tw T* (\023\030\017)Tj /Span<>> BDC ( )Tj EMC (\024\021\f\031\021\f\021\r\017\017 cCR \023\024\022\026\026\027\024 \r\t\ \023\024\035\027\036\027\017\036 \230\204\224. \211)Tj /Span<>> BDC ( )Tj EMC (\023\026)Tj 0 Tw (-)Tj 0.312 Tw T* (\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\027\017\022\017\n\017 \024\023\031\b\024\035\016\n\017 \r\024 \n\027\024\ \020\017\b \f\035\031\004\026\016\b )Tj 0.15 Tw T* (\220\021\024 \024\027\026\004\026\036\021 \r\t\023\024\035\027\036\027\017\ \036 \022\026\035\036\004\026\013\017\b \b\017\030\031\030\020\017\004\036\ \f\022\017\b )Tj 0.216 Tw T* (\r\n\036\001\026\021\036\035\034\f\021\r. \025\024\027\006\036\023\006\017\ \016 \007\017\027\026\n\017\004\036\f\022\024\020\024 \027\026\002\035\033\ \007\036)Tj 0 Tw (-)Tj 0.192 Tw T* [(\027\017\016 )0.5(\026)]TJ /Span<>> BDC ( )Tj EMC 3.24 0 Td [(\220\021\017\n\017 )0.6(\023\026\006\017\036\027\021\026\n\017, )0.5(\023\030\017\n\036\027\016\036\n\026\016 )0.6(\r)]TJ /Span<>> BDC ( )Tj EMC 15.203 0 Td [(\030\016\007\036 )0.5(\017\f)]TJ 0 Tw (-)Tj -0.017 Tw -18.443 -1.218 Td (\f\035\036\007\024\r\026\027\017\005 \026)Tj /Span<>> BDC ( )Tj EMC (\030\031\002\036\032\024\n, \016\r\035\016\036\021\f\016 \f\023\024\030\027\ \024\005 \017)Tj /Span<>> BDC ( )Tj EMC (\027\036 \017\n\036\036\021 )Tj 0.249 Tw T* (\007\024\f\021\026\021\024\004\027\024\020\024 \023\024\007\021\r\036\030\ \032\007\036\027\017\016 \r)Tj /Span<>> BDC ( )Tj EMC (\030\026\n\022\026\b \030\026\027\007\024\n\017\017)Tj 0 Tw (-)Tj 0.071 Tw T* [(\030\024\r\026\027\027\t\b )0.6(\022\035\017\027\017\004\036\f\022\017\b )0.5(\017\f\f\035\036\007\024\r\026\027\017\005. )0.6(\203\026\001 )0.5(\024\023\t\021 )0.6(\r\t)]TJ 0 Tw (-)Tj -0.029 Tw T* (\023\024\035\027\036\027\017\016 \230\224\204 \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (nCR \023\024\f\035\036 \216\214\230 \r)Tj /Span<>> BDC ( )Tj EMC (\022\026\004\036\f\021\r\036 )Tj 0.101 Tw T* (\030\026\f\001\017\030\036\027\027\024\005 \002\017\024\023\f\017\017 \024\ \027\t \030\026\027\036\036 \030\026\f\023\024\035\026\020\026\r\001\036\ \005\f\016 )Tj 0.003 Tw T* (\024\023\031\b\024\035\017 \023\024\022\026\t\r\026\036\021, \004\021\024\ \023\030\017\n\036\027\036\027\017\036 \007\026\027\027\024\020\024 \n\036\ \021\024\007\026 )Tj 0.079 Tw 23.244 64.543 Td (\r\024\n\024\032\027\024 \017)Tj /Span<>> BDC ( )Tj EMC (\002\036\024\023\026\f\027\024. \215\030\017\n\036\027\036\027\017\036 \ \036\020\024 \024\020\030\026\027\017\004\036\027\024 )Tj 0.109 Tw 0 -1.218 TD (\031\022\024\005 \022\026\021\036\020\024\030\017\036\005 \023\026\006\017\ \036\027\021\024\r)Tj /Span<>> BDC ( )Tj EMC (\227 \023\024\032\017\035\t\b, \024\f\035\026\002\035\036\027)Tj 0 Tw (-)Tj 0.199 Tw 0 -1.218 TD (\027\t\b, \f)Tj /Span<>> BDC ( )Tj EMC (\r\t\030\026\032\036\027\027\024\005 \f\024\023\031\021\f\021\r\031\033\013\ \036\005 \023\026\021\024\035\024\020\017\036\005 \017\035\017 )Tj 0.226 Tw 0 -1.218 TD (\r)Tj /Span<>> BDC ( )Tj EMC 0.933 0 Td [(\f\035\031\004\026\016\b )0.6(\022\026\021\036\020\024\030\017\004\036\f\022\024\020\024 )0.6(\024\021\022\026\026 )0.5(\024\021 )0.5(\030\026\007\017\022\026\035\034\027\024\020\024 )]TJ 0.09 Tw -0.933 -1.218 Td (\b\017\030\031\030\020\017\004\036\f\022\024\020\024 \r\n\036\001\026\021\ \036\035\034\f\021\r\026. \211)Tj /Span<>> BDC ( )Tj EMC (\007\026\027\027\t\b \023\026\006\017\036\027\021\024\r )Tj -0.026 Tw 0 -1.218 TD (\230\224\204 \027\036 \021\024\035\034\022\024 \023\024\r\024\035\016\036\ \021 \024\023\030\036\007\036\035\017\021\034 \023\026\021\024\n\024\030\ \235\024\035\024\020\017)Tj 0 Tw (-)Tj -0.044 Tw 0 -1.218 TD (\004\036\f\022\017\005 \b\026\030\026\022\021\036\030 \024\f\021\026\021\ \024\004\027\t\b \017\n\036\027\036\027\017\005 \f\021\036\027\022\017 \ \022\017\001\022\017 )Tj 0.003 Tw 0 -1.218 TD (\017)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\021\017\022\031 \035\036\004\036\027\017\016, \027\024 \017\ )Tj /Span<>> BDC ( )Tj EMC (\n\024\032\036\021 \f\021\026\021\034 \030\026\007\017\022\026\035\034\027\ \t\n \b\017)Tj 0 Tw (-)Tj 0.168 Tw T* (\030\031\030\020\017\004\036\f\022\017\n \r\n\036\001\026\021\036\035\034\ \f\021\r\024\n \f)Tj /Span<>> BDC ( )Tj EMC (\024\021\027\024\f\017\021\036\035\034\027\024 \027\036\r\t)Tj 0 Tw (-)Tj T* (\f\024\022\017\n \030\017\f\022\024\n \n\036\f\021\027\024\020\024 \030\036\ \006\017\007\017\r\026.)Tj /T1_2 1 Tf 0.023 Tw 0 -2.436 TD (\223\030\032\255\020\034\036 \032\026\020\017\022\017\026)Tj /T1_0 1 Tf 0.065 Tw 0 -1.218 TD [(\025)-4.1(\024)-4.3(\027)1.7(\006)-6(\036)-6.8(\023)2.2(\006)-6(\017)-5.4(\016 \017)]TJ /Span<>> BDC ( )Tj EMC [(\007)-6(\017)2.7()-9.9(\026\005)1.7(\027 \017)-2.4(\f)3.1(\f)-38.9(\035)-6.8(\036)-19(\007)-4.4(\024)-4.3(\r)-8.9(\026\027)1.7(\017)-5.5(\016)13.7(:)]TJ /T1_3 1 Tf [( \217)11.8(\031)6.6(\027)-0.8(\n)10.1(\023)11.6(\022\t)4(\013)12.7(\025)-11.5(\004)]TJ /Span<>> BDC ( )Tj EMC [(\201)-2.3(.)7.3(\201)-2.3(.)7.9(, )]TJ 0 Tw T* [(\215)20.8(\027)2.1(\026)4.3(\021)3.8(\n)9.6(\027)]TJ /Span<>> BDC ( )Tj EMC [(\207)-2.1(.)7.3(\201)-2.3(.)7.8(, \222)16.1(\026)1.8(\033)6.4(\032)6.4(\025)7.2(\021)]TJ /Span<>> BDC ( )Tj EMC [(\201)-2.2(.)-9.6(\200)1.4(.)]TJ /T1_0 1 Tf 0.68 Tw T* [(\221)-4.6(\002)-9.9(\024)0.7(\030 \017)]TJ /Span<>> BDC ( )Tj EMC [(\024)-11.8(\002)3(\030)-11.4(\026)-6.3(\002)-9.9(\024)-10.9(\021)-17.7(\022)-19.1(\026 \n)1.3(\026)-11.8(\021)-9.9(\036)-1.7(\030)-7.6(\017)-0.6(\026)-33.1(\035)-2.5(\024)-4.3(\r)10.5(:)]TJ /T1_3 1 Tf [( \213)14.2(\032\n\030)1.4(\t)4(\013)12.7(\025)10.1(\017)]TJ /Span<>> BDC ( )Tj EMC [(\201)-2.3(.)29.3(\212)93.9(.)7.8(, )]TJ 0 Tw T* [(\201)13.7(\027)-0.8(\030)1.9(\031)-0.9(\031)2.3(\021)10.7(\013)9.9(\n)]TJ /Span<>> BDC ( )Tj EMC [(\216)24.4(.)7.3(\201)-2.3(.)7.8(, \240)10.6(\025)-11.5(\004)7.6(\026)-5.2(\023)3.4(\031)6.6(\027)2.1(\026)]TJ /Span<>> BDC ( )Tj EMC [(\223)26.6(.)27.5(\223)26.6(.)7.8(, )8.9(\n)10.8(\006\205)3.5(\031)6.6(\027)]TJ /Span<>> BDC ( )Tj EMC [(\220)65(.)29.3()29.4(.)]TJ /T1_0 1 Tf 0.018 Tc 1.537 Tw T* [(\221)35.2(\021)-3.5(\026)6.2(\021\017)15.7(\f)-18(\021\017)22.5(\004)9.8(\036)7.6(\f)16.4(\022)-1.1(\026)-3(\016)18( \024)6.2(\002)21(\030)6.6(\026)11.7(\002)8.2(\024)7.1(\021\022)-1.1(\026)21.7(:)]TJ /T1_3 1 Tf -0.002 Tc 1.557 Tw 12.904 0 Td [( \201)11.7(\027)-2.8(\030\031)-2.9(\031\021)8.7(\013)7.8(\n)]TJ /Span<>> BDC 5.581 0 Td ( )Tj EMC [(\216)22.3(.)5.3(\201)-4.3(.)5.8(,)-2( )]TJ -0.012 Tc 0.012 Tw -18.485 -1.218 Td [(\217\031)-5.4(\027)-12.8(\n)-1.8(\023\022)-11.9(\t)-8(\013)0.7(\025)-23.5(\004)]TJ /Span<>> BDC 4.589 0 Td ( )Tj EMC [(\201)-14.3(.)-4.7(\201)-14.3(.)]TJ /T1_0 1 Tf 0.002 Tc 0.279 Tw -4.589 -1.218 Td [(\203)7.2(\026\023)4.2(\017\f)-10.8(\026)1.7(\027)3.7(\017)-6.7(\036)2.1( \021)-7.9(\036)-3.3(\022\f)-34(\021)-19.5(\026)5.7(:)]TJ /T1_3 1 Tf 0 Tc 0.281 Tw 7.975 0 Td [( \217)11.7(\031)6.6(\027)-0.8(\n)10.1(\023)11.7(\022\t)4(\013)12.7(\025)-11.5(\004)]TJ /Span<>> BDC ( )Tj EMC [(\201)-2.3(.)7.3(\201)-2.3(.)7.8(, \201)13.7(\027)-0.8(\030)1.9(\031)-0.9(\031)2.3(\021)10.7(\013)9.9(\n)]TJ /Span<>> BDC ( )Tj EMC [(\216)24.4(.)7.3(\201)-2.3(.)7.8(, )]TJ -0.027 Tc 0.027 Tw -7.975 -1.218 Td [(\240)-16.4(\025)-38.5(\004)-19.4(\026)-32.2(\023)-23.6(\031)-20.4(\027)-24.9(\026)]TJ /Span<>> BDC 3.894 0 Td ( )Tj EMC [(\223.)0.5(\223.)]TJ /T1_0 1 Tf 0 Tc 0 Tw -3.894 -1.218 Td [(\217)5.5(\036)-19(\007)-20.1(\026\022)-32.6(\021)-17.7(\017)1.4(\030)-11.8(\024)-4.2(\r)-9(\026\027)1.8(\017)-8.7(\036)6.5(:)]TJ /T1_3 1 Tf 1.017 Tw [( \213)14.1(\032\n\030)1.4(\t)4(\013)12.7(\025)10.1(\017)]TJ /Span<>> BDC ( )Tj EMC [(\201)-2.3(.)29.3(\212)93.9(.)7.8(, )8.8(\n)10.8(\006\205)3.5(\031)6.6(\027)]TJ /Span<>> BDC ( )Tj EMC [(\220)65(.)29.3()29.3(.)7.8(, )]TJ 0.89 Tw T* [(\213\031)-0.9(\032\031)-14.4(\016)2.2(\n)9.7(\027)-1.3(\t)4(\013)12.7(\026)2.1(\002)]TJ /Span<>> BDC ( )Tj EMC [(\220)65.1(.)29.3()29.3(.)7.8(, \221)14.3(\025)1.8(\005)8.1(\025)4.7(\032\n)9.6(\027)]TJ /Span<>> BDC ( )Tj EMC [(\212)93.9(.)76.6(\225)54.7(.)7.8(, \240)11.3(\002)7.9(\023)9.6(\025)7.2(\021)9.5(\026)]TJ /Span<>> BDC ( )Tj EMC [(\207)-2.1(.)7.3(\201)-2.3(.)7.9(, )]TJ 0 Tw T* [(\255)0.5(\032\031)-26(\004)4.7(\n)9.6(\027)]TJ /Span<>> BDC ( )Tj EMC [(\215)28.9(.)7.3(\201)-2.3(.)7.8(, )8.8(\031\024)6(\032\n)9.6(\027)]TJ /Span<>> BDC ( )Tj EMC [(\035)25(.)43.7(\255)27.6(.)]TJ /T1_2 1 Tf 0.023 Tw 0 -2.436 TD (AUTHORS CONTRIBUTION)Tj /T1_0 1 Tf -0.016 Tw 0 -1.218 TD [(C)-6.5(o)0.8(nce)-0.7(p)-12.3(t a)2.4(n)-4.6(d d)-5.5(e)-13.3(s)-16.6(i)3.2(g)1.2(n o)-2.1(f t)-16.7(h)-5.3(e s)-20(t)-12.8(ud)-10.9(y)-11.7(:)]TJ /T1_3 1 Tf [( A)3.6(l)4.8(ek)-17.5(s)5(e)-2.5(y)]TJ /Span<>> BDC ( )Tj EMC [(A)-12.6(.)]TJ /Span<>> BDC ( )Tj EMC [(N)2.3(e)-4(v)7.6(o)-1(l)-28.6(s)9.1(k)-18.5(i)7.9(k)5.3(h)-6(, )]TJ 0 Tw T* [(S)5.6(e)-1.7(r)2.3(g)-2.5(e)-2.5(y)]TJ /Span<>> BDC ( )Tj EMC [(A)-12.6(.)]TJ /Span<>> BDC ( )Tj EMC [(I)14.1(v)10.8(a)-0.8(n)1.9(o)-0.6(v)33.6(, A)3.8(n)-0.6(d)5.3(r)2.4(e)-2.5(y)]TJ /Span<>> BDC ( )Tj EMC [(D)23.9(.)]TJ /Span<>> BDC ( )Tj EMC [(K)12.8(a)-0.8(p)1.5(r)-35.3(i)8.5(n)]TJ /T1_0 1 Tf 1.15 Tw T* [(C)-6.5(o)-5.8(l)-19(l)-14.3(e)-9.4(c)-32.5(t)-37.3(i)3.2(o)0.8(n a)2.4(n)-4.6(d p)-3.8(r)-6(o)-7(ce)-13.3(s)-12.8(s)-16.6(i)7.1(n)-1.9(g o)-2.2(f t)-16.7(h)-5.3(e m)1.8(a)-8.4(t)-15.2(e)-2.1(r)-48(i)]TJ 0 Tw 21.758 0 Td (-)Tj 0.002 Tc -0.002 Tw -21.758 -1.218 Td [(a)0.5(l)-20.5(:)]TJ /T1_3 1 Tf 0 Tc 0.596 Tw 1.042 0 Td [( A)3.6(l)4.9(e)-28.6(x)5(a)-0.8(n)-0.6(d)-1(e)-1.7(r)]TJ /Span<>> BDC ( )Tj EMC [(R)-2.5(.)]TJ /Span<>> BDC ( )Tj EMC [(B)6(r)2.4(o)-7.8(d)-1.4(s)9.1(k)-18.5(iy)16.5(, V)-5.4(i)3(o)-1.1(l)4.8(e)-4.4(t)-28.1(t)2.3(a)]TJ /Span<>> BDC ( )Tj EMC [(A)-12.6(.)]TJ /Span<>> BDC ( )Tj EMC [(A)8.6(v)7.1(d)-0.9(e)-6.2(e)-2.6(n)7.5(k)12.9(o)-3.7(, )]TJ 0 Tw -1.042 -1.218 Td [(Y)33.7(u)2.8(l)4.3(i)5.9(a)]TJ /Span<>> BDC ( )Tj EMC [(Y)33.7(u)7.7(.)]TJ /Span<>> BDC ( )Tj EMC [(M)10.5(i)8.4(h)4.8(al)4.8(e)-3.9(v)10.7(a)-13.9(, T)49.7(ar)7.7(a)-3(s)]TJ /Span<>> BDC ( )Tj EMC [(P)81.5(.)]TJ /Span<>> BDC ( )Tj EMC [(P)25(o)-8.3(c)1.8(h)8.2(u)1.2(e)-4(v)]TJ /T1_0 1 Tf -0.007 Tc 1.119 Tw T* [(St)-34.7(a)-15.4(t)-44.4(i)-4.3(s)-27(t)-44.4(i)-1.8(c)-18.8(a)-8.5(l)-7( p)-10.8(r)-13(o)-14(c)-6.8(e)-20.3(s)-19.8(s)-23.6(in)-8.9(g)2(:)]TJ /T1_3 1 Tf 0 Tc 1.112 Tw 10.2 0 Td [( V)-5.5(i)3(o)-1.1(l)4.8(e)-4.4(t)-28.1(t)2.3(a)]TJ /Span<>> BDC ( )Tj EMC [(A)-12.6(.)]TJ /Span<>> BDC ( )Tj EMC [(A)8.6(v)7.1(d)-1(e)-6.2(e)-2.6(n)7.5(k)13(o)-3.8(, )]TJ -0.005 Tc 0.005 Tw -10.2 -1.218 Td [(A)-1.4(le)-5.3(k)-22.5(se)-7.5(y)]TJ /Span<>> BDC 2.941 0 Td ( )Tj EMC [(A)-17.6(.)]TJ /Span<>> BDC 1.08 0 Td ( )Tj EMC [(N)-2.7(e)-9(v)2.6(o)-6.1(l)-33.6(s)4.1(k)-23.4(i)2.9(kh)]TJ /T1_0 1 Tf 0 Tc 0.881 Tw -4.021 -1.218 Td [(W)3.1(r)-48(i)-6(t)-37.4(i)7.1(n)-1.9(g o)-2.2(f t)-16.7(h)-5.2(e t)-15.1(e)-23.9(x)-36(t)-20.1(:)]TJ /T1_3 1 Tf [( A)3.6(l)4.8(ek)-17.5(s)4.9(e)-2.4(y)]TJ /Span<>> BDC ( )Tj EMC [(A)-12.6(.)]TJ /Span<>> BDC ( )Tj EMC [(N)2.4(e)-4(v)7.6(o)-1.1(l)-28.6(s)9.1(k)-18.5(i)7.9(k)5.3(h)-6(, )]TJ 0 Tw T* [(V)-5.5(i)3(o)-1.1(l)4.8(e)-4.4(t)-28(t)2.3(a)]TJ /Span<>> BDC ( )Tj EMC [(A)-12.6(.)]TJ /Span<>> BDC ( )Tj EMC [(A)8.6(v)7.1(d)-1(e)-6.2(e)-2.5(n)7.5(k)12.9(o)-3.7(, Y)33.7(u)2.8(l)4.3(i)5.9(a)]TJ /Span<>> BDC ( )Tj EMC [(Y)33.8(u)7.7(. M)10.5(i)8.4(h)4.8(al)4.8(e)-3.9(v)10.8(a)]TJ /T1_0 1 Tf 0.006 Tc -0.006 Tw T* [(E)11.6(dit)-31.4(i)13.1(n)4.1(g)15(:)]TJ /T1_3 1 Tf 0 Tc 0.52 Tw 3.238 0 Td [( A)3.6(l)4.9(e)-28.6(x)5(a)-0.8(n)-0.6(d)-1(e)-1.7(r)]TJ /Span<>> BDC ( )Tj EMC [(R)-2.5(.)]TJ /Span<>> BDC ( )Tj EMC [(B)6(r)2.4(o)-7.8(d)-1.4(s)9.1(k)-18.5(iy)16.5(, T)49.8(ar)7.7(a)-3(s)]TJ /Span<>> BDC ( )Tj EMC [(P)81.4(.)]TJ /Span<>> BDC ( )Tj EMC [(P)25(o)-8.3(c)1.8(h)8.2(u)1.2(e)-4(v)33.6(, )]TJ 1.152 Tw -3.238 -1.218 Td [(T)49.7(a)-4.9(t)-25.2(i)5.9(a)-0.8(n)4.9(a)]TJ /Span<>> BDC ( )Tj EMC [(P)81.4(.)]TJ /Span<>> BDC ( )Tj EMC [(B)0.8(e)-1.7(r)2.4(e)-17(z)12.4(o)-0.6(v)-3.9(s)9.1(k)15.8(a)-5.8(y)3.8(a)-14(, R)10.2(us)9.3(l)3.3(a)-0.8(n)]TJ /Span<>> BDC ( )Tj EMC [(F)65.2(.)]TJ /Span<>> BDC ( )Tj EMC [(Z)9.6(i)9.1(b)3.3(i)9.4(r)2.4(o)-0.6(v)33.6(, )]TJ 0 Tw T* [(S)5.6(o)9.7(\233)6.5(a)]TJ /Span<>> BDC ( )Tj EMC [(A)-12.5(.)]TJ /Span<>> BDC ( )Tj EMC [(M)4.3(y)3.8(al)4.3(i)8.4(n)4.8(a)-14(, I)14.1(v)10.8(a)-0.8(n)]TJ /Span<>> BDC ( )Tj EMC [(A)-12.6(.)]TJ /Span<>> BDC ( )Tj EMC [(O)-4.1(r)2.5(eh)1.8(ov)33.6(, L)-3.6(e)-6.2(on)6.2(i)3(d)]TJ /Span<>> BDC ( )Tj EMC [(O)13.2(.)]TJ /Span<>> BDC ( )Tj EMC [(P)24(e)-4.4(t)-5.4(r)2.4(o)-0.6(v)]TJ /T1_2 1 Tf 0.023 Tw 0 -2.436 TD (\255\026\036\031\036\025\034\224 \017\225 \032\026\020\017\022\032\221 \(\ ORCID\))Tj /T1_0 1 Tf 0.034 Tw 0 -1.218 TD (\203\036\r\024\035\034\f\022\017\b \202\035\036\022\f\036\005 \202\035\036\ \022\f\036\036\r\017\004)Tj /Span<>> BDC ( )Tj EMC (\227 \007\024\022\021\024\030 \n\036\007\017\006\017\027)Tj 0 Tw (-)Tj 0.039 Tw T* (\f\022\017\b \027\026\031\022, \026\n\036\f\021\017\021\036\035\034 \007\ \017\030\036\022\021\024\030\026 \023\024)Tj /Span<>> BDC ( )Tj EMC (\035\036\004\036\002\027\024\005 \030\026\002\024)Tj 0 Tw (-)Tj 0.152 Tw T* (\021\036 \204\217\203\037 \017\n\036\027\017 \202.\205. \037\t\002\026)Tj /Span<>> BDC ( )Tj EMC (\227 \235\017\035\017\026\035 \205\206\207\211 \253\203\204\222\037 )Tj 0.09 Tw T* (\030\026\007\017\024\035\024\020\017\017\273 \204\017\027\007\030\026\r\ \026 \217\024\f\f\017\017, \210\002\027\017\027\f\022; SPIN-\022\024\007\ : )Tj 0 Tw T* (3787-6139; ORCID: 0000-0001-5961-2958)Tj 0.145 Tw T* [(\207\030\024\007\f\022\017\005 )0.5(\202\035\036\022\f\026\027\007\030 )0.6(\217\031\021\036\027\034\036\r\017\004)]TJ /Span<>> BDC ( )Tj EMC 14.166 0 Td [(\227 )0.5(\022\026\027\007\017\007\026\021 )0.6(\n\036\007\017)]TJ 0 Tw (-)Tj 0.065 Tw -14.166 -1.218 Td (\006\017\027\f\022\017\b \027\026\031\022, \r\030\026\004-\b\017\030\031\ \030\020 \024\021\007\036\035\036\027\017\016 \035\031\004\036\r\024\020\ \024 \017)Tj /Span<>> BDC ( )Tj EMC (\b\017)Tj 0 Tw (-)Tj 0.232 Tw T* (\030\031\030\020\017\004\036\f\022\024\020\024 \035\036\004\036\027\017\016\ \026\002\024\035\036\r\026\027\017\005 \026\002\007\024\n\017\027\026\035\ \034\027\024\005 )Tj 0.288 Tw T* [(\024\002\035\026\f\021\017 )0.5(\204\217\203\037 )0.6(\017\n\036\027\017 )0.5(\202.\205. )0.5(\037\t\002\026)]TJ /Span<>> BDC ( )Tj EMC 14.836 0 Td [(\227 )0.5(\235\017\035\017\026\035 )0.5(\205\206\207\211 )]TJ 0.353 Tw -14.836 -1.218 Td [(\253\203\204\222\037 \030\026\007\017\024\035\024\020\017\017\273 \204\017\ \027\007\030\026\r\026 )0.5(\217\024\f\f\017\017, \210\002\027\017\027\f\022; )]TJ 0 Tw T* (ORCID: 0000-0002-4709-1726)Tj 0.025 Tw T* [(\202\r\007\036\036\027\022\024 )0.5(\200\017\024\035\036\021\021\026 )0.6(\202\027\007\030\036\036\r\027\026)]TJ /Span<>> BDC ( )Tj EMC 12.874 0 Td [(\227 )0.5(\022\035\017\027\017\004\036\f\022\017\005 )0.6(\024\030\007\017)]TJ 0 Tw (-)Tj -0.036 Tw -12.874 -1.218 Td (\027\026\021\024\030 \204\217\203\037 \017\n\036\027\017 \202.\205. \037\ \t\002\026)Tj /Span<>> BDC ( )Tj EMC (\227 \235\017\035\017\026\035 \205\206\207\211 \253\203\204\222\037 )Tj 0.407 Tw T* [(\030\026\007\017\024\035\024\020\017\017\273 \204\017\027\007\030\026\r\ \026 )0.5(\217\024\f\f\017\017, \210\002\027\017\027\f\022; ORCID: )]TJ 0 Tw T* (0000-0002-2678-016X)Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\033\030\031\030\213\b)-20.9(\035\231\213\233\t \021\032)50(\b)42(\032\231\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj -51.938 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 23, \023\0221)69(, 202)69(4)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 23, \023\0221)69(, 202)69(4)]TJ /T1_5 1 Tf 25 0 0 25 28.1526 56.0378 Tm (88)Tj ET endstream endobj 1626 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\032)30(\002\013\001\006\013\001\013\007\216\001\020\016 \232\001\201\025\024\220\ \n\002\025\207\220\002\215\002\202\220\017\016\006\n\220\016 \r\024\016\ \013\026)11(\016\007\216\006)-10(\026\r\013 )]TJ 0 -1 TD [(\221\002\220\022\002\013\n\016 \221\002\205\024\025\203 \n\220\n\220 \221\ \025\006)-10(\007\016 \007\215\017\016\r\025\203 \220\007\220 )]TJ T* [(\207\220\024\220\025\007\215\017\016\r\025\203 \026)11(\016\002\013\221\220\220\022\236 \001\212\013\001\006\020 \220\022\002\016\ \222)21.1(\215\007\216)21(\026)11(\013\026\020)]TJ 32.955 2 Td [(T)20(r)21(ansanal endoscopic micr)20(osur)31(ger)-31(y af)-31(ter r)21(adiation or ch)11(emor)21(adiation )]TJ 7.251 -1 Td [(th)11(er)21(apy for r)31(ectal cancer\022\236 peculiarities and r)31(esults)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0.075 Tw 10 0 0 10 42.5197 724.8299 Tm (\002\024\035\034\027\t\b \031\007\026\036\021\f\016 \r\t\023\024\035\027\ \017\021\034 \030\026\007\017\022\026\035\034\027\031\033 \230\204\224, \ \017)Tj /Span<>> BDC ( )Tj EMC (\r\t)Tj 0 Tw (-)Tj 0.329 Tw 0 -1.218 TD (\032\017\r\026\036\n\024\f\021\034 \017\b \f\030\026\r\027\017\n\026 \f)Tj /Span<>> BDC ( )Tj EMC (\r\t\032\017\r\026\036\n\024\f\021\034\033 \023\024\f\035\036 )Tj 0.456 Tw T* (\024\002\t\004\027\024\020\024 \b\017\030\031\030\020\017\004\036\f\022\024\ \020\024 \r\n\036\001\026\021\036\035\034\f\021\r\026 [3,4,29]. )Tj 0.088 Tw T* (\215\030\017)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\n \004\026\f\021\024\021\026 \f\024\b\030\026\027\036\027\017\ \016 \023\030\016\n\024\005 \022\017\001\022\017 \022\026\022 \024\030)Tj 0 Tw (-)Tj 0.159 Tw T* (\020\026\027\026 \017)Tj /Span<>> BDC ( )Tj EMC (\r\t\032\017\r\026\036\n\024\f\021\034 \002\036 \f\021\024\n\t \007\024\ \f\021\017\020\026\033\021 85\22690% )Tj 0.141 Tw T* ([29]. \221\035\036\007\031\036\021 \024\021\n\036\021\017\021\034, \004\021\ \024 \r)Tj /Span<>> BDC ( )Tj EMC (\027\026\001\036\005 \030\026\002\024\021\036 \023\024\022\026\026)Tj 0 Tw (-)Tj 0.39 Tw 0 -1.218 TD (\021\036\035\034 \022\031\n\031\035\016\021\017\r\027\024\005 \021\030\036\ \b\035\036\021\027\036\005 \r\t\032\017\r\026\036\n\024\f\021\017 \002\036\  )Tj -0.04 Tw 0 -1.218 TD (\f\021\024\n\t \f\024\f\021\026\r\017\035 92,9)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (6,9%, \004\021\024 \r)Tj /Span<>> BDC ( )Tj EMC (\006\036\035\024\n \f\024\024\021\r\036\021\f\021\r\031\036\021 )Tj 0 Tw T* (\007\026\027\027\t\n \007\030\031\020\017\b \017\f\f\035\036\007\024\r\026\ \027\017\005.)Tj 0.207 Tw T* (\025\024\035\017\004\036\f\021\r\024 \027\026\002\035\033\007\036\027\017\ \005 \r)Tj /Span<>> BDC ( )Tj EMC (\027\026\001\036\005 \030\026\002\024\021\036 \023\030\036\007\f\021\026\ \r)Tj 0 Tw (-)Tj 0.114 Tw T* (\035\016\036\021\f\016 \027\036\002\024\035\034\001\017\n \r)Tj /Span<>> BDC ( )Tj EMC (\f\030\026\r\027\036\027\017\017 \f)Tj /Span<>> BDC ( )Tj EMC (\007\026\027\027\t\n\017 \n\036\021\026\026\027\026)Tj 0 Tw (-)Tj 0.148 Tw T* (\035\017\024\r \017)Tj /Span<>> BDC ( )Tj EMC [(\n\027\024\020\024\006\036\027\021\030\024\r\t\b )0.5(\017\f\f\035\036\007\024\r\026\027\017\005)]TJ /Span<>> BDC ( )Tj EMC 17.101 0 Td (\227 \r\f\036\020\024 20 )Tj 0.227 Tw -17.101 -1.218 Td [(\023\026\006\017\036\027\021\024\r. )0.6(\211)]TJ /Span<>> BDC ( )Tj EMC 6.031 0 Td [(\002\024\035\034\001\036\005 )0.5(\004\026\f\021\017 )0.6(\023\026\006\017\036\027\021\024\r )0.5(\023\030\017\n\036\027\016\035\017 )]TJ 0.094 Tw -6.031 -1.218 Td (\023\030\024\035\024\027\020\017\030\024\r\026\027\027\t\005 \030\036\032\ \017\n \216\214\230 \r)Tj /Span<>> BDC ( )Tj EMC (\f\024\004\036\021\026\027\017\017 \f)Tj /Span<>> BDC ( )Tj EMC (\022\024\027\f\024)Tj 0 Tw (-)Tj 0.354 Tw T* [(\035\017\007\017\030\031\033\013\036\005 )0.6(\b\017\n\017\024\021\036\030\026\023\017\036\005, )0.5(\017\027\021\036\027\f\017\r\027\024\036 )0.6(\024\002\035\031\004\036)]TJ 0 Tw (-)Tj 0.168 Tw T* (\027\017\036 \r)Tj /Span<>> BDC ( )Tj EMC (\f\024\004\036\021\026\027\017\017 \f)Tj /Span<>> BDC ( )Tj EMC (\022\024\027\f\024\035\017\007\017\030\031\033\013\036\005 \b\017\n\017\024\ \021\036\030\026\023\017)Tj 0 Tw (-)Tj 0.082 Tw T* (\036\005 \002\t\035\024 \023\030\024\r\036\007\036\027\024 1 \023\026\006\ \017\036\027\021\022\036. \230\024\035\034\022\024 \r)Tj /Span<>> BDC ( )Tj EMC (4 \f\035\031\004\026\016\b )Tj 0.079 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (20 \023\030\024\r\024\007\017\035\017 \214\230/\216\214\230 \002\036 \022\ \024\027\f\024\035\017\007\026\006\017\017. \221\035\036\007\031\036\021\ )Tj 0.115 Tw T* (\f\022\026\026\021\034, \004\021\024 \r)Tj /Span<>> BDC ( )Tj EMC (\027\026\f\021\024\016\013\036\036 \r\030\036\n\016 \027\036 \r\t\t\r\026\ \036\021 \f\024\n\027\036)Tj 0 Tw (-)Tj 0.041 Tw T* (\027\017\005, \004\021\024 \022\024\027\f\024\035\017\007\017\030\031\033\ \013\026\016 \b\017\n\017\024\021\036\030\026\023\017\016 \220\235\235\036\ \022\021\017\r)Tj 0 Tw (-)Tj -0.015 Tw T* (\027\036\036 \023\024)Tj /Span<>> BDC ( )Tj EMC (\f\030\026\r\027\036\027\017\033 \f)Tj /Span<>> BDC ( )Tj EMC (\017\027\007\031\022\006\017\024\027\027\024\005 \023\024)Tj /Span<>> BDC ( )Tj EMC (\004\026\f\021\024\021\036 \023\024\035\027\t\b )Tj 0.176 Tw T* [(\024\021\r\036\021\024\r, )0.5(\004\021\024 )0.6(\024\f\024\002\036\027\027\024 )0.5(\r\026\032\027\024 )0.5(\007\035\016 )0.5(\023\026\006\017\036\027\021\024\r )0.6(\f)]TJ /Span<>> BDC ( )Tj EMC 20.308 0 Td (\007\017\f)Tj 0 Tw (-)Tj 0.189 Tw -20.308 -1.218 Td (\021\026\035\034\027\t\n\017 \024\023\031\b\024\035\016\n\017 \023\030\016\ \n\024\005 \022\017\001\022\017 [6,10]. \222\n\036\027\027\024 )Tj 0.114 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC 0.821 0 Td [(\220\021\017\b )0.5(\f\035\031\004\026\016\b )0.6(\023\030\017\n\036\027\036\027\017\036 )0.6(\024\030\020\026\027\024\f\024\b\030\026\027\016\033\013\017\b )0.5(\n\036)]TJ 0 Tw (-)Tj 0.011 Tw -0.821 -1.218 Td (\021\024\007\024\r \035\036\004\036\027\017\016 \024\f\024\002\036\027\027\ \024 \024\023\030\026\r\007\026\027\024, \021\026\022 \022\026\022 \023\024\ \r\024\035\016)Tj 0 Tw (-)Tj T* (\036\021 \017\002\036\032\026\021\034 \023\024\032\017\027\036\027\027\ \024\005 \022\024\035\024\f\021\024\n\t.)Tj 0.23 Tw T* (\217\016\007 \017\f\f\035\036\007\024\r\026\021\036\035\036\005 \r)Tj /Span<>> BDC ( )Tj EMC (\f\r\024\017\b \030\026\002\024\021\026\b \024\021\n\036\004\026\035\017\ \027\036)Tj 0 Tw (-)Tj 0.654 Tw T* [(\007\024\023\031\f\021\017\n\024 )0.6(\r\t\f\024\022\031\033 )0.5(\004\026\f\021\024\021\031 )0.5(\023\024\f\035\036\024\023\036\030\026\006\017\024\027\027\t\b )]TJ 0.28 Tw T* (\024\f\035\024\032\027\036\027\017\005 \031)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\034\027\t\b \023\024\f\035\036 \216\214\230 \f)Tj /Span<>> BDC ( )Tj EMC (\023\024\f\035\036\007\031\033\013\036\005 )Tj 0.015 Tw T* [(\230\224\204. \230\026\022, P)30(er)-24(ez R. \017)]TJ /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. [30] \024\021\n\036\021\017\035\017 \024\f\035\024\032\ \027\036\027\017\016 )Tj 0.077 Tw T* (\031)Tj /Span<>> BDC ( )Tj EMC 0.754 0 Td [(56% )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 3.323 0 Td [(23 )0.5(\023\026\006\017\036\027\021\024\r, )0.6(\023\030\017)]TJ /Span<>> BDC ( )Tj EMC 7.956 0 Td [(\220\021\024\n )0.5(\031)]TJ /Span<>> BDC ( )Tj EMC 2.959 0 Td [(30% )0.5(\024\f\035\024\032\027\036\027\017\016 )]TJ 0.607 Tw -14.993 -1.218 Td [(\023\024\021\030\036\002\024\r\026\035\017 )0.5(\023\024\r\021\024\030\027\t\b )0.5(\020\024\f\023\017\021\026\035\017\026\006\017\005. )0.6(\210\007\027\026\022\024 )]TJ 0.121 Tw T* [(\220\021\017 \007\026\027\027\t\036 \027\036 \f\024\020\035\026\f\031\033\ \021\f\016 )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC [(\027\026\001\017\n\017 )0.5(\030\036\031\035\034\021\026\021\026\n\017: )]TJ 0.044 Tw T* (\n\t \024\021\n\036\021\017\035\017 \024\f\035\024\032\027\036\027\017\016\ \031)Tj /Span<>> BDC ( )Tj EMC (20% \023\026\006\017\036\027\021\024\r, \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\n )Tj 0.162 Tw T* (\024\f\035\024\032\027\036\027\017\016 3 \f\021\036\023\036\027\017)Tj /Span<>> BDC ( )Tj EMC (\227 \021\024\035\034\022\024 \031)Tj /Span<>> BDC ( )Tj EMC (5%, \027\017 \r)Tj /Span<>> BDC ( )Tj EMC (\024\007\027\024\n )Tj 0.29 Tw T* (\f\035\031\004\026\036 \024\027\017 \027\036 \023\030\017\r\036\035\017 \ \022)Tj /Span<>> BDC ( )Tj EMC (\023\024\r\021\024\030\027\024\005 \020\024\f\023\017\021\026\035\017\026\ )Tj 0 Tw (-)Tj 0.108 Tw T* [(\006\017\017 \023\026\006\017\036\027\021\024\r. \217\036\031\035\034\021\ \026\021\t )0.5(\022\030\031\023\027\t\b \023\024\023\031\035\016\006\017\024\027\027\t\b\ )]TJ -0.039 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\n\027\024\020\024\006\036\027\021\030\024\r\t\b \017\f\f\035\036\007\024\ \r\026\027\017\005, \r)Tj /Span<>> BDC ( )Tj EMC (\022\024\021\024\030\t\b \023\030\017\n\036\027\016)Tj 0 Tw (-)Tj -0.004 Tw T* [(\035\017 )0.5(\230\224\204, )0.5(\023\024\022\026\t\r\026\033\021, )0.5(\004\021\024 )0.5(\027\036\023\024\f\030\036\007\f\021\r\036\027\027\t\036 )0.6(\030\036\031\035\034\021\026)]TJ 0 Tw (-)Tj 0.034 Tw T* (\021\t \007\026\027\027\024\005 \n\036\021\024\007\017\022\017 \r)Tj /Span<>> BDC ( )Tj EMC (\027\026\004\017\021\036\035\034\027\024\005 \f\021\036\023\036\027\017\ \026\r\017\f\016\021 )Tj 0.004 Tw T* (\024\021 \f\021\026\027\007\026\030\021\017\026\006\017\017 \017)Tj /Span<>> BDC ( )Tj EMC (\024\023\t\021\026 \b\017\030\031\030\020\026 [12,20,21]. \025\030\024\n\ \036 )Tj 0.437 Tw T* (\021\024\020\024, \004\026\f\021\024\021\026 \024\f\035\024\032\027\036\027\ \017\005 \023\030\016\n\024\023\030\024\023\024\030\006\017\024\027\026\035\ \034\027\024 )Tj 0.145 Tw T* [(\026\r\017\f\017\021 )0.6(\024\021 )0.5(\020\035\031\002\017\027\t )0.5(\030\036\036\022\006\017\017 )0.6(\n\036\024\030\036\022\021\026\035\034\027\024\005 )0.6(\022\035\036\021)]TJ 0 Tw (-)Tj 0.228 Tw T* (\004\026\021\022\017 [20]. \210\002\013\026\016 \004\026\f\021\024\021\026\ \023\024\f\035\036\024\023\036\030\026\006\017\024\027\027\t\b \024\f)Tj 0 Tw (-)Tj 0.105 Tw T* (\035\024\032\027\036\027\017\005 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\024\021\030\026\002\024\021\026\027\027\024\005 \021\036\b\027\017\022\036\ \b\017\030\031\030\020\017\004\036\f\022\017\b )Tj 0.118 Tw T* (\r\n\036\001\026\021\036\035\034\f\021\r \002\036 \030\036\036\022\006\ \017\017 \n\036\024\030\036\022\021\031\n\026 \f\024\f\021\026\r\035\016\ \036\021 )Tj 0.224 Tw T* (\024\022\024\035\024 20%, \026)Tj /Span<>> BDC ( )Tj EMC (\024\f\035\024\032\027\036\027\017\016)Tj /Span<>> BDC ( )Tj EMC (\241)Tj /Span<>> BDC ( )Tj EMC (3 \f\021\036\023\036\027\017 \023\024)Tj /Span<>> BDC ( )Tj EMC [(Cl)-16(av)-16(ien-)]TJ 0 Tw T* [(Dind)-16(o \027\036 \023\030\036\r\t\001\026\036\021 10% [12,20,21].)]TJ 0.225 Tw T* (\215\030\017\n\036\030\027\024 \031)Tj /Span<>> BDC ( )Tj EMC (\022\026\032\007\024\020\024 \021\030\036\021\034\036\020\024 \023\026\006\ \017\036\027\021\026 \023\024\f\035\036 \230\224\204 )Tj 0.464 Tw T* (\023\030\017)Tj /Span<>> BDC ( )Tj EMC 2.217 0 Td [(\023\026\021\024\n\024\030\235\024\035\024\020\017\004\036\f\022\024\n )0.6(\017\f\f\035\036\007\024\r\026\027\017\017 )0.6(\r\t\016\r\035\016)]TJ 0 Tw (-)Tj 0.199 Tw -2.217 -1.218 Td [(\033\021\f\016 \235\026\022\021\024\030\t \027\036\002\035\026\020\024\023\ \030\017\016\021\027\024\020\024 )0.5(\023\030\024\020\027\024\026, \021\030\036\002\031\033)]TJ 0 Tw (-)Tj 0.073 Tw T* (\013\017\036 \r\t\023\024\035\027\036\027\017\016 \026\r\036\030\001\026\ \033\013\036\005 \230\204\224 [18,20,22,29,31]. )Tj 0.364 Tw T* (\215\030\017)Tj /Span<>> BDC ( )Tj EMC 2.217 0 Td [(\220\021\024\n )0.5(\023\030\024\023\024\030\006\017\016 )0.6(\002\024\035\034\027\t\b, )0.6(\022\024\021\024\030\t\n )0.5(\r\t\023\024\035\027\016)]TJ 0 Tw (-)Tj 0.228 Tw -2.217 -1.218 Td (\033\021\f\016 \026\r\036\030\001\026\033\013\017\036 \024\023\036\030\026\ \006\017\017, \f\024\f\021\026\r\035\016\036\021 \027\036 \002\024\035\036\ \036 )Tj 0.086 Tw 23.244 64.543 Td (\023\024\035\024\r\017\027\t \024\021 \021\036\b, \022\024\n\031 \024\027\ \017 \023\024\022\026\026\027\t [12,20,22]. \230\026\022, )Tj 0.672 Tw T* [(\023\024\f\035\036 )0.6(\023\026\021\024\n\024\030\235\024\035\024\020\017\004\036\f\022\024\005\ )0.6(\024\006\036\027\022\017 )0.5(\023\030\036\023\026\030\026\021\024\r )]TJ -0.044 Tw T* (\031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r, \r\022\035\033\004\036\027\027\t\b \r\ )Tj /Span<>> BDC ( )Tj EMC (\n\027\024\020\024\006\036\027\021\030\024\r\024\036 \235\030\026\027\006\ \031)Tj 0 Tw (-)Tj 0.12 Tw T* [(\f\022\024\036 \017\f\f\035\036\007\024\r\026\027\017\036 \020\030\031\023\ \023\t GRECC)20(AR [17], \023\024\022\026\026\027\017\016 )]TJ 0.113 Tw T* (\022)Tj /Span<>> BDC ( )Tj EMC (\026\r\036\030\001\026\033\013\036\005 \230\204\224 \017\n\036\035\017 \ 42% \002\024\035\034\027\t\b \(108/257\), )Tj 0 Tw T* (\027\024 \024\027\026 \002\t\035\026 \r\t\023\024\035\027\036\027\026 \035\ \017\001\034 \r)Tj /Span<>> BDC ( )Tj EMC (42 \f\035\031\004\026\016\b \(38,8%\).)Tj 0.009 Tw 0 -1.218 TD (\200 \027\026\001\036\005 \030\026\002\024\021\036 \235\026\022\021\024\030\ \t \027\036\002\035\026\020\024\023\030\017\016\021\027\024\020\024 \023\ \030\024\020\027\024\026 )Tj 0.027 Tw 0 -1.218 TD (\002\t\035\017 \r\t\016\r\035\036\027\t \031)Tj /Span<>> BDC ( )Tj EMC (7)Tj /Span<>> BDC ( )Tj EMC (\(35,0%\) \002\024\035\034\027\t\b, \026)Tj /Span<>> BDC ( )Tj EMC (\026\r\036\030\001\026\033\013\017\036 )Tj 0.084 Tw T* (\230\204\224 \r\t\023\024\035\027\036\027\t \035\017\001\034 \r)Tj /Span<>> BDC ( )Tj EMC (2 \(28,6%\) \f\035\031\004\026\016\b. \211)Tj /Span<>> BDC ( )Tj EMC (\024\f\021\026\035\034)Tj 0 Tw (-)Tj 0.054 Tw T* (\027\t\b 5 \023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\023\024\022\026\026\027\017\016\n\017 \022)Tj /Span<>> BDC ( )Tj EMC (\026\r\036\030\001\026\033\013\036\005 \230\204\224 )Tj 0.049 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC [(2 \(10,0%\) \f\035\031\004\026\016\b \017\n\036\035\026\f\034 yp\2301s)26(m3, \r)]TJ /Span<>> BDC ( )Tj EMC (2 \(10,0%\))Tj /Span<>> BDC ( )Tj EMC (\227 )Tj 0.218 Tw T* (yp\2302 \022\026\021\036\020\024\030\017\016 \024\023\031\b\024\035\017 \ \017)Tj /Span<>> BDC ( )Tj EMC (\036\013\036 \031)Tj /Span<>> BDC ( )Tj EMC (1 \(5,0%\) \023\026\006\017\036\027)Tj 0 Tw (-)Tj 0.222 Tw 0 -1.218 TD (\021\026 \f)Tj /Span<>> BDC ( )Tj EMC (yp\230is)Tj /Span<>> BDC ( )Tj EMC (\227 \023\024\035\024\032\017\021\036\035\034\027\026\016 \006\017\030\022\ \031\035\016\030\027\026\016 \020\030\026\027\017\006\026 )Tj 0.104 Tw 0 -1.218 TD (\030\036\036\022\006\017\017. \221\035\036\007\031\036\021 \f\022\026\026\ \021\034, \004\021\024 \027\017 \031)Tj /Span<>> BDC ( )Tj EMC (\024\007\027\024\020\024 \017)Tj /Span<>> BDC ( )Tj EMC (5)Tj /Span<>> BDC ( )Tj EMC (\023\026)Tj 0 Tw (-)Tj 0.255 Tw 0 -1.218 TD (\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\027\036\002\035\026\020\024\023\030\017\016\021\027\t\n\017 \235\026\022\ \021\024\030\026\n\017 \023\030\024\020\027\024\026, )Tj 0.159 Tw T* (\024\021\022\026\026\r\001\017\b\f\016 \024\021 \023\024\r\021\024\030\027\ \024\005 \024\023\036\030\026\006\017\017, \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\n\036\007\017\026\027\036 )Tj 0.151 Tw T* (\027\026\002\035\033\007\036\027\017\016 31,5 \n\036\f\016\006\036\r \027\ \036 \r\024\027\017\022\035\017 \n\036\f\021\027\t\036 \030\036)Tj 0 Tw (-)Tj 0.238 Tw T* (\006\017\007\017\r\t. \221\030\026\r\027\017\r\026\016 \007\026\027\027\t\ \036 \027\026\f\021\024\016\013\036\020\024 \017\f\f\035\036\007\024\r\026\ )Tj 0 Tw (-)Tj 0.107 Tw T* (\027\017\016 \f)Tj /Span<>> BDC ( )Tj EMC (\030\036\031\035\034\021\026\021\026\n\017 \035\036\004\036\027\017\016\ \002\024\035\034\027\t\b \217\215\025 \002\036 \023\030\036\007)Tj 0 Tw (-)Tj T* [(\001\036\f\021\r\031\033\013\036\020\024 )0.5(\024\002\035\031\004\036\027\017\016, )0.5(\f\035\036\007\031\036\021 \024\021\n\036\021\017\021\034, )0.5(\004\021\024 \031)]TJ /Span<>> BDC ( )Tj EMC (\r\f\036\b )Tj 0.304 Tw T* (5)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (pT2 \022\026\021\036\020\024\030\017\036\005, \r\024\027\017\022\035\017\ \n\036\f\021\027\t\036 )Tj 0.014 Tw T* (\030\036\006\017\007\017\r\t [32]. \230\026\022\017\n \024\002\030\026\024\ \n, pT2 \023\024\f\035\036 \230\224\204 \017)Tj /Span<>> BDC ( )Tj EMC (ypT2 )Tj 0.07 Tw T* [(\023\024\f\035\036 )0.6(\214\230/\216\214\230 )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC 6.817 0 Td (\230\224\204)Tj /Span<>> BDC ( )Tj EMC 1.903 0 Td [(\227 )0.6(\220\021\024 )0.5(\027\036 )0.6(\024\007\027\024 )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC 7.338 0 Td [(\021\024 )0.6(\032\036, )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 3.615 0 Td (\030\017\f\022\017 )Tj 0.126 Tw -19.674 -1.218 Td (\n\036\f\021\027\024\020\024 \030\036\006\017\007\017\r\026 \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (ypT2 \027\026\004\017\021\036\035\034\027\024 )Tj 0 Tw T* (\n\036\027\034\001\036.)Tj 0.131 Tw T* (\200 \035\017\021\036\030\026\021\031\030\036 \n\026\035\024 \007\026\027\ \027\t\b \024)Tj /Span<>> BDC ( )Tj EMC (\004\026\f\021\024\021\036 \n\036\f\021\027\t\b \030\036\006\017)Tj 0 Tw (-)Tj 0.228 Tw T* (\007\017\r\024\r \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r, \024\021\022\026\026\r\001\017\b\f\016\ \024\021 \026\r\036\030\001\026\033\013\036\005 )Tj 0.163 Tw T* (\230\204\224. \200)Tj /Span<>> BDC ( )Tj EMC (\024\f\027\024\r\027\024\n, \030\036\004\034 \017\007\036\021 \024)Tj /Span<>> BDC ( )Tj EMC (\030\036\021\030\024\f\023\036\022\021\017\r\027\t\b \017\f)Tj 0 Tw (-)Tj 0.525 Tw T* (\f\035\036\007\024\r\026\027\017\016\b \f)Tj /Span<>> BDC ( )Tj EMC (\n\026\035\t\n \022\024\035\017\004\036\f\021\r\024\n \027\026\002\035\033\ \007\036\027\017\005. )Tj 0.228 Tw T* (\200)Tj /Span<>> BDC ( )Tj EMC [(\f\017\f\021\036\n\026\021\017\004\036\f\022\024\n \024\002\024\030\036\ Hall)-15.9(am)]TJ /Span<>> BDC ( )Tj EMC (S. \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. [21] )Tj 0.012 Tw T* [(\004\026\f\021\024\021\026 \n\036\f\021\027\t\b )0.5(\030\036\006\017\007\017\r\024\r )0.5(\031)]TJ /Span<>> BDC ( )Tj EMC [(\023\026\006\017\036\027\021\024\r )0.5(ypT2 \022\026\021\036\020\024)]TJ 0 Tw (-)Tj 0.086 Tw T* (\030\017\036\005, \024\021\022\026\026\r\001\017\b\f\016 \024\021 \026\ \r\036\030\001\026\033\013\036\005 \230\204\224, \f\024\f\021\026\r\017\035\ \026 )Tj -0.028 Tw T* (23,6% [95% \212\222 13,0\22636,1%]. \215\030\017)Tj /Span<>> BDC ( )Tj EMC (ypT1 \022\026\021\036\020\024\030\017\017 \007\026\027)Tj 0 Tw (-)Tj 0.045 Tw T* (\027\t\005 \023\024\022\026\026\021\036\035\034 \f\024\f\021\026\r\017\035\ 12,1% [95% \212\222 6,3\22619,4%], )Tj 0.059 Tw T* (\026)Tj /Span<>> BDC ( )Tj EMC (\023\030\017 ypT3)Tj /Span<>> BDC ( )Tj EMC (\227 59,6% [95% \212\222 32,6\22683,8%], \030\026\035\017\004\017\016 )Tj 0.037 Tw T* [(\f\021\026\021\017\f\021\017\004\036\f\022\017 \027\026\004\017\n\t\036\ )0.5(\()]TJ /T1_2 1 Tf 0 Tw (\032)Tj /T1_1 1 Tf 0.037 Tw /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (0,001\). \200)Tj /Span<>> BDC ( )Tj EMC (\007\030\031\020\024\n \017\f\f\035\036)Tj 0 Tw (-)Tj 0.105 Tw T* [(\007\024\r\026\027\017\017 )0.5(Geubels )0.6(B.M. )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 10.289 0 Td [(\f\024\026\r\021. )0.5([12] )0.5(\004\026\f\021\024\021\026 )0.6(\n\036\f\021\027\t\b )]TJ 0.07 Tw -10.289 -1.218 Td (\030\036\006\017\007\017\r\024\r \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \023\024\f\035\036 \035\024\022\026\035\ \034\027\024\020\024 \017\f\f\036\004\036\027\017\016 )Tj -0.012 Tw T* (\024\023\031\b\024\035\017 \f\024\f\021\026\r\017\035\026 22%, \r\f\036\n\ \023\026\006\017\036\027\021\026\n \002\t\035\026 \r\t\023\024\035)Tj 0 Tw (-)Tj T* (\027\036\027\026 \026\r\036\030\001\026\033\013\026\016 \230\204\224.)Tj 0.238 Tw T* (\210\021\007\026\035\036\027\027\t\036 \n\036\021\026\f\021\026\t \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\b\024\030\024\001\017\n \024\021)Tj 0 Tw (-)Tj 0.069 Tw T* (\r\036\021\024\n \027\026)Tj /Span<>> BDC ( )Tj EMC (\214\230/\216\214\230, \022\024\021\024\030\t\n \r\t\023\024\035\027\016\ \033\021 \035\024\022\026\035\034\027\024\036 \017\f)Tj 0 Tw (-)Tj 0.122 Tw T* (\f\036\004\036\027\017\036 \024\023\031\b\024\035\017, \r)Tj /Span<>> BDC ( )Tj EMC (\006\036\035\024\n \024\021\n\036\004\026\033\021\f\016 \024\021\027\024\ \f\017\021\036\035\034\027\024 )Tj 0.221 Tw T* (\030\036\007\022\024 \017)Tj /Span<>> BDC ( )Tj EMC (\004\026\013\036 \r\f\021\030\036\004\026\033\021\f\016 \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\n\036\f\021\027\t\n )Tj 0.275 Tw T* (\030\036\006\017\007\017\r\024\n [15,18]. \200)Tj /Span<>> BDC ( )Tj EMC (\027\026\001\036\n \017\f\f\035\036\007\024\r\026\027\017\017 \021\024\035\ \034\022\024 )Tj 0.007 Tw T* (\031)Tj /Span<>> BDC ( )Tj EMC (1 \(5%\) \017)Tj /Span<>> BDC ( )Tj EMC (20 \023\026\006\017\036\027\021\024\r \002\t\035\017 \024\021\n\036\004\036\ \027\t \024\021\007\026\035\036\027\027\t\036 )Tj 0.119 Tw T* (\n\036\021\026\f\021\026\t \r)Tj /Span<>> BDC ( )Tj EMC (\f\024\004\036\021\026\027\017\017 \f)Tj /Span<>> BDC ( )Tj EMC (\n\036\f\021\027\t\n \030\036\006\017\007\017\r\024\n. \200)Tj /Span<>> BDC ( )Tj EMC (\030\026)Tj 0 Tw (-)Tj 0.012 Tw T* [(\002\024\021\036 P)30(el)56(tr)-37(ini [33] \007\024\f\021\024\r\036\030\027\t\b \030\026\035\017\004\017\005\ \n\036\032\007\031 ypT0-)]TJ 0.07 Tw T* [(T)35(is-T1 \017)]TJ /Span<>> BDC ( )Tj EMC (ypT2 \r)Tj /Span<>> BDC ( )Tj EMC (\004\026\f\021\017 \024\021\007\026\035\036\027\027\024\020\024 \n\036\021\ \026\f\021\026\017\030\024\r\026\027\017\016 )Tj 0.192 Tw T* (\023\024\035\031\004\036\027\024 \027\036 \002\t\035\024)Tj /Span<>> BDC ( )Tj EMC (\227 1,7% \017)Tj /Span<>> BDC ( )Tj EMC (4,3%, \f\024\024\021\r\036\021\f\021\r\036\027\027\024, )Tj 0 Tw T* (\()Tj /T1_2 1 Tf (p)Tj /T1_1 1 Tf 0.017 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,66\). \215\030\017)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\n \027\026\035\017\004\017\036 ypT2 \022\026\021\036\020\024\ \030\017\017 \024\023\031\b\024\035\017 )Tj 0.035 Tw T* (\021\026\022\032\036 \007\024\f\021\024\r\036\030\027\024 \027\036 \r\035\ \017\016\035\024 \027\026)Tj /Span<>> BDC ( )Tj EMC (\004\017\f\035\024 \n\036\f\021\027\t\b \030\036\006\017)Tj 0 Tw (-)Tj 0.061 Tw T* (\007\017\r\024\r)Tj /Span<>> BDC ( )Tj EMC (\227 3,4% \017)Tj /Span<>> BDC ( )Tj EMC (8,7%, \f\024\024\021\r\036\021\f\021\r\036\027\027\024, \()Tj /T1_2 1 Tf 0 Tw (p)Tj /T1_1 1 Tf 0.061 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,30\). \203\024 )Tj 0.086 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC 0.836 0 Td [(\r )0.6(\021\024\n, )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 3.583 0 Td [(\r )0.6(\007\030\031\020\024\n )0.5(\f\035\031\004\026\036 )0.6(\r\017\007\027\026 )0.6(\021\036\027\007\036\027\006\017\016 )0.6(\022)]TJ /Span<>> BDC ( )Tj EMC 15.275 0 Td (\002\024\035\036\036 )Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 0 Tw 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\033\030\031\030\213\b)-20.9(\035\231\213\233\t \021\032)50(\b)42(\032\231\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj /T1_3 1 Tf 25 0 0 25 512.9144 56.0378 Tm (87)Tj ET endstream endobj 1625 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.118 Tw 10 0 0 10 70.8661 724.8299 Tm (\023\030\016\n\024\005 \022\017\001\022\017 \f)Tj /Span<>> BDC ( )Tj EMC (\023\026\b\024\r\024\005 \035\017\n\235\026\007\036\027\220\022\021\024\n\ \017\036\005 R0. \203\017 )Tj 0.085 Tw 0 -1.218 TD (\r)Tj /Span<>> BDC ( )Tj EMC (\024\007\027\024\n \f\035\031\004\026\036 \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\023\024\022\026\026\027\017\016\n\017 \022)Tj /Span<>> BDC ( )Tj EMC (\026\r\036\030)Tj 0 Tw (-)Tj 0.016 Tw T* (\001\026\033\013\036\005 \230\204\224 \017)Tj /Span<>> BDC ( )Tj EMC (\n\036\f\021\027\024\020\024 \023\030\024\020\030\036\f\f\017\030\024\r\026\ \027\017\016 \024\021\n\036\004\036\027\024 )Tj 0.071 Tw T* (\027\036 \002\t\035\024. \212\r\024\036 \023\026\006\017\036\027\021\024\ \r \031\n\036\030\035\017 \r \023\030\024\006\036\f\f\036 \027\026\002\035\ \033)Tj 0 Tw (-)Tj 0.048 Tw T* (\007\036\027\017\016: \r)Tj /Span<>> BDC ( )Tj EMC (\024\007\027\024\n \f\035\031\004\026\036 \027\026)Tj /Span<>> BDC ( )Tj EMC (\f\030\024\022\036 31,4 \n\036\f\016\006\026 \024\021 \024\021\007\026)Tj 0 Tw (-)Tj 0.005 Tw T* [(\035\036\027\027\024\020\024 )0.6(\n\036\021\026\f\021\026\017\030\024\r\026\027\017\016, )0.6(\r)]TJ /Span<>> BDC ( )Tj EMC 12.251 0 Td (\007\030\031\020\024\n)Tj /Span<>> BDC ( )Tj EMC 3.12 0 Td [(\227 )0.5(\027\026)]TJ /Span<>> BDC ( )Tj EMC 2.449 0 Td [(\f\030\024\022\036 )0.5(31,5 )]TJ 0 Tw -17.821 -1.218 Td (\n\036\f\016\006\036\r \024\021 \022\024\027\022\031\030\017\030\031\033\ \013\036\020\024 \026\002\024\035\036\r\026\027\017\016.)Tj 0.236 Tw T* (\025\031\n\031\035\016\021\017\r\027\026\016 \021\030\036\b\035\036\021\027\ \016\016 \004\026\f\021\024\021\026 \n\036\f\021\027\t\b \030\036\006\017\ \007\017)Tj 0 Tw (-)Tj 0.206 Tw T* (\r\024\r \f\024\f\021\026\r\017\035\026 6,2)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (6,1%. \210\002\013\026\016 \017)Tj /Span<>> BDC ( )Tj EMC (\002\036\030\036\006\017\007\017\r\027\026\016 )Tj 0.233 Tw T* [(\021\030\036\b\035\036\021\027\016\016 )0.6(\r\t\032\017\r\026\036\n\024\f\021\034 )0.6(\f\024\f\021\026\r\017\035\017, )0.5(\f\024\024\021\r\036\021\f\021\r\036\027)]TJ 0 Tw (-)Tj 0.076 Tw T* (\027\024, 83,3)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (10,8% \017)Tj /Span<>> BDC ( )Tj EMC (80,4)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (10,4%, \026)Tj /Span<>> BDC ( )Tj EMC (\r\t\032\017\r\026\036\n\024\f\021\034 \002\036 )Tj 0 Tw T* (\f\021\024\n\t)Tj /Span<>> BDC ( )Tj EMC (\227 92,9)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (6,9%.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 70.936 554.3378 Tm [(\037\036)10(\032\223\212\226\034\022\031\034)]TJ 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0 Tc 0.077 Tw 10 0 0 10 70.8661 529.9818 Tm (\214\024\022\026\035\034\027\024\036 \017\f\f\036\004\036\027\017\036 \024\ \023\031\b\024\035\017 \023\024\f\035\036 \214\230/\216\214\230 \016\r\035\ \016\036\021)Tj 0 Tw (-)Tj 0.186 Tw T* (\f\016 \007\017\f\022\031\021\026\002\036\035\034\027\t\n \r\024\023\030\ \024\f\024\n, \027\026)Tj /Span<>> BDC ( )Tj EMC (\022\024\021\024\030\t\005 \023\024\022\026 \027\036\021 )Tj 0.015 Tw T* (\024\007\027\024\027\026\004\027\024\020\024 \024\021\r\036\021\026. \215\ \030\017)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\n \030\016\007 \026\r\021\024\030\024\r \r)Tj /Span<>> BDC ( )Tj EMC (\030\026\n\022\026\b )Tj 0.409 Tw T* (\023\030\024\f\023\036\022\021\017\r\027\t\b \017\f\f\035\036\007\024\r\026\ \027\017\005 \023\030\024\007\024\035\032\026\033\021 \023\030\017\n\036\ )Tj 0 Tw (-)Tj 0.106 Tw T* (\027\016\021\034 \220\021\024\021 \n\036\021\024\007 \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (cCR \017\035\017 nCR [11\22616], )Tj 0.195 Tw T* (\021\024\020\007\026 \022\026\022 \027\026\004\017\021\036\035\034\027\024\ \036 \004\017\f\035\024 \017\f\f\035\036\007\024\r\026\021\036\035\036\005\ \f\004\017)Tj 0 Tw (-)Tj 0.103 Tw T* (\021\026\033\021 \220\021\024 \027\036\006\036\035\036\f\024\024\002\030\ \026\027\t\n [17\22619]. \214\033\002\026\016 \021\024\021\026\035\034)Tj 0 Tw (-)Tj -0.002 Tw T* (\027\026\016 \002\017\024\023\f\017\016 \024\027\t \024\023\031\b\024\035\ \036\r\024\020\024 \030\031\002\006\026 \017\035\017 \024\f\021\026\021\024\ \004\027\024\005 )Tj 0.054 Tw T* (\024\023\031\b\024\035\017 \(\230\224\204, \230\224\210, \230\202\204IS,\ \021\030\026\027\f\026\027\026\035\034\027\024\036 \023\024\035\027\024\ \f\021\036\027)Tj 0 Tw (-)Tj -0.037 Tw T* (\027\024\036 \031\007\026\035\036\027\017\036\) \023\030\036\007\023\024\ \035\026\020\026\036\021 \023\024\035\027\024\f\021\036\027\027\024\036 \ \017\f\f\036\004\036\027\017\036 )Tj 0.081 Tw T* [(\031\004\026\f\021\022\026 )0.5(\021\022\026\027\017 \022\017\001\022\017 \f)]TJ /Span<>> BDC ( )Tj EMC 9.771 0 Td [(\023\024\f\035\036\007\031\033\013\017\n )0.5(\031\001\017\r\026\027\017\036\n )0.5(\007\036)]TJ 0 Tw (-)Tj 0.136 Tw -9.771 -1.218 Td (\235\036\022\021\026. \203\036\f\n\024\021\030\016 \027\026)Tj /Span<>> BDC ( )Tj EMC (\n\026\035\024\017\027\r\026\017\r\027\024\f\021\034 \220\021\024\020\024\ \b\017\030\031\030)Tj 0 Tw (-)Tj 0.226 Tw T* (\020\017\004\036\f\022\024\020\024 \r\n\036\001\026\021\036\035\034\f\021\ \r\026, \004\026\f\021\024\021\026 \023\024\f\035\036\024\023\036\030\026\ \006\017\024\027)Tj 0 Tw (-)Tj 0.139 Tw T* (\027\t\b \024\f\035\024\032\027\036\027\017\005 \f\024\f\021\026\r\035\016\ \036\021 \024\022\024\035\024 20%, \017)Tj /Span<>> BDC ( )Tj EMC (\022\024\021\024\030\t\b )Tj 0.109 Tw T* (\024\f\035\024\032\027\036\027\017\016)Tj /Span<>> BDC ( )Tj EMC (\241)Tj /Span<>> BDC ( )Tj EMC (3 \f\021\036\023\036\027\017 \023\024)Tj /Span<>> BDC ( )Tj EMC [(\022\035\026\f\f\017\235\017\022\026\006\017\017 Cl)-15.9(av)-16(ien-)]TJ 0.314 Tw T* [(Dind)-16(o)]TJ /Span<>> BDC ( )Tj EMC (\227 8\22610% [12,20,21]. \204\027\024\020\017\036 \026\r\021\024\030\t \ \024\021\n\036)Tj 0 Tw (-)Tj 0.331 Tw T* [(\004\026\033\021 )0.5(\027\036\002\035\026\020\024\023\030\017\016\021\027\t\005 )0.6(\235\031\027\022\006\017\024\027\026\035\034\027\t\005 )0.6(\030\036\031\035\034\021\026\021 )]TJ 0.124 Tw T* (\035\024\022\026\035\034\027\t\b \n\036\021\024\007\024\r \017\f\f\036\004\ \036\027\017\016 \024\023\031\b\024\035\017 \r)Tj /Span<>> BDC ( )Tj EMC (\f\030\026\r\027\036\027\017\017 )Tj 0.044 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\027\036\024\023\036\030\017\030\024\r\026\027\027\t\n\017 \023\026\006\017\ \036\027\021\026\n\017 [8,18]. \025\030\024\n\036 \021\024\020\024, )Tj 0.279 Tw T* (\235\017\002\030\024\027\t\036 \017)Tj /Span<>> BDC ( )Tj EMC (\030\031\002\006\024\r\t\036 \017\n\036\027\036\027\017\016 \r)Tj /Span<>> BDC ( )Tj EMC (\024\022\030\031\032\026\033\013\036\005 )Tj 0.124 Tw T* (\022\035\036\021\004\026\021\022\036 \026\021\030\031\007\027\016\033\021\ \023\024\f\035\036\007\031\033\013\036\036 \r\t\016\r\035\036\027\017\036\ \023\024\r)Tj 0 Tw (-)Tj -0.008 Tw T* (\021\024\030\027\024\020\024 \030\024\f\021\026 \024\023\031\b\024\035\017\ [5,18]. \200)Tj /Span<>> BDC ( )Tj EMC (\f\035\031\004\026\036, \036\f\035\017 \021\030\036\002\031\036\021)Tj 0 Tw (-)Tj 0.124 Tw T* (\f\016 \026\r\036\030\001\026\033\013\026\016 \230\204\224 \023\030\017\ )Tj /Span<>> BDC ( )Tj EMC (\r\t\016\r\035\036\027\017\017 \027\036\002\035\026\020\024\023\030\017\016\ \021)Tj 0 Tw (-)Tj 0.056 Tw T* (\027\t\b \235\026\022\021\024\030\024\r \023\030\024\020\027\024\026 \(\ \241)Tj /Span<>> BDC ( )Tj EMC (ypT2, N+, \r\024\r\035\036\004\036\027\017\036 \037\206\217, )Tj 0.211 Tw T* (\023\036\030\017\027\036\r\030\026\035\034\027\026\016 \017\035\017 \f\024\ \f\031\007\017\f\021\026\016 \017\027\r\026\017\016, \007\036\023\024\017\ \021\t )Tj 0.153 Tw T* (\024\023\031\b\024\035\017\) \017\035\017 \f\023\026\f\017\021\036\035\034\ \027\026\016 \230\204\224 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\r\t\016\r\035\036\027\017\017 \030\036)Tj 0 Tw (-)Tj 0.137 Tw T* (\006\017\007\017\r\026, \b\017\030\031\030\020\017\004\036\f\022\017\036\ \r\n\036\001\026\021\036\035\034\f\021\r\026, \022\026\022 \023\030\026\ \r\017\035\024, )Tj 0.359 Tw T* (\027\024\f\016\021 \024\002\f\021\030\031\022\021\017\r\027\t\005 \b\026\ \030\026\022\021\036\030 \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\023\030\024\r\024\032\007\026\033\021\f\016 )Tj 0.415 Tw T* (\002\024\035\034\001\017\n \004\017\f\035\024\n \023\024\f\035\036\024\023\ \036\030\026\006\017\024\027\027\t\b \024\f\035\024\032\027\036\027\017\005\ )Tj -0.011 Tw T* (\023\024)Tj /Span<>> BDC ( )Tj EMC (\f\030\026\r\027\036\027\017\033 \f)Tj /Span<>> BDC ( )Tj EMC (\230\224\204 \023\024)Tj /Span<>> BDC ( )Tj EMC (\023\024\r\024\007\031 \023\024\r\021\024\030\027\024\020\024 \030\024\f\ \021\026 \024\023\031)Tj 0 Tw (-)Tj 0.068 Tw T* (\b\024\035\017 \027\026)Tj /Span<>> BDC ( )Tj EMC (\235\024\027\036 \026\022\021\017\r\027\024\020\024 \007\017\027\026\n\017\ \004\036\f\022\024\020\024 \027\026\002\035\033\007\036\027\017\016 )Tj 0.13 Tw T* (\026)Tj /Span<>> BDC ( )Tj EMC 1.252 0 Td [(\023\026\006\017\036\027\021\026\n\017 )0.6(\f)]TJ /Span<>> BDC ( )Tj EMC 6.062 0 Td [(cCR )0.5([19]. )0.6(\207\024\035\036\036 )0.5(\023\024\035\024\r\017\027\t )0.5(\023\026\006\017\036\027)]TJ 0 Tw (-)Tj -0.008 Tw -7.314 -1.218 Td (\021\024\r \023\024\f\035\036 \230\224\204 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\r\t\016\r\035\036\027\017\017 \031)Tj /Span<>> BDC ( )Tj EMC (\027\017\b \027\036\002\035\026\020\024\023\030\017\016\021\027\t\b )Tj 0.07 Tw T* (\235\026\022\021\024\030\024\r \023\030\024\020\027\024\026 \r)Tj /Span<>> BDC ( )Tj EMC (\023\030\017\027\006\017\023\036 \024\021\022\026\t\r\026\033\021\f\016\ \024\021 \r\t)Tj 0 Tw (-)Tj 0.087 Tw T* (\023\024\035\027\036\027\017\016 \026\r\036\030\001\026\033\013\036\005\ \230\204\224 \f)Tj /Span<>> BDC ( )Tj EMC (\r\t\f\024\022\017\n \030\017\f\022\024\n \023\024\r)Tj 0 Tw (-)Tj T* (\021\024\030\027\024\020\024 \030\024\f\021\026 \024\023\031\b\024\035\017\ [12,22].)Tj 0.267 Tw T* (\221\035\036\007\031\036\021 \f\022\026\026\021\034, \004\021\024 \r)Tj /Span<>> BDC ( )Tj EMC (\027\026\f\021\024\016\013\036\036 \r\030\036\n\016 \002\024\035\034\001\ \017\027)Tj 0 Tw (-)Tj 0.599 Tw T* (\f\021\r\024 \017\f\f\035\036\007\024\r\026\021\036\035\036\005 \f\004\017\ \021\026\033\021 \027\036\006\036\035\036\f\024\024\002\030\026\027\t\n\ )Tj 0.074 Tw 23.244 64.543 Td (\r\t\023\024\035\027\036\027\017\036 \230\224\204 \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\026\030\036\020\017\f\021\030\017\030\024\r\026\027\027\t\n )Tj 0.031 Tw 0 -1.218 TD (cCR. \210\007\027\026\022\024 \r\026\032\027\024 \023\024\027\017\n\026\021\ \034, \004\021\024 \032\036 \021\026\022\024\036 cCR. \200)Tj /Span<>> BDC ( )Tj EMC (\027\026)Tj 0 Tw (-)Tj 0.266 Tw 0 -1.218 TD (\f\021\024\016\013\036\036 \r\030\036\n\016 cCR \024\023\030\036\007\036\ \035\016\036\021\f\016 \023\024)Tj /Span<>> BDC ( )Tj EMC (\f\024\r\024\022\031\023\027\024\f\021\017 )Tj 0.343 Tw 0 -1.218 TD (\030\036\031\035\034\021\026\021\024\r \021\030\036\b \022\035\017\027\017\ \004\036\f\022\017\b \017\f\f\035\036\007\024\r\026\027\017\005, \030\036\ \022)Tj 0 Tw (-)Tj 0.12 Tw 0 -1.218 TD [(\021\026\035\034\027\024\020\024 )0.5(\023\026\035\034\006\036\r\024\020\024, \220\027\007\024\f\022\024\023\017\ \004\036\f\022\024\020\024 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 18.022 0 Td (\204\217\230 \f)Tj /Span<>> BDC ( )Tj EMC 2.781 0 Td (\017\f)Tj 0 Tw (-)Tj 0.724 Tw -20.803 -1.218 Td (\023\024\035\034\024\r\026\027\017\036\n \030\036\032\017\n\026 \007\017\ \235\235\031\017\024\027\027\024-\r\r\036\001\036\027\027\t\b )Tj 0.204 Tw T* [(\017\024\002\030\026\032\036\027\017\005. )0.6(\217\036\022\021\026\035\034\027\024\036 )0.5(\023\026\035\034\006\036\r\024\036 )0.5(\017\f\f\035\036\007\024\r\026\027\017\036, )]TJ 0.15 Tw 0 -1.218 TD (\027\036\f\n\024\021\030\016 \027\026)Tj /Span<>> BDC ( )Tj EMC (\f\r\024\033 \023\030\024\f\021\024\021\031, \016\r\035\016\036\021\f\016\ , \023\024-\r\017\007\017\n\024\n\031, )Tj 0.231 Tw T* (\022\035\033\004\036\r\t\n \n\036\021\024\007\024\n \007\017\026\020\027\ \024\f\021\017\022\017. \213\f\035\017 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\023\026\035\034\023\026)Tj 0 Tw (-)Tj 0.278 Tw T* [(\006\017\017 )0.5(\024\027\t )0.5(\030\026\027\036\036 )0.5(\f\031\013\036\f\021\r\024\r\026\r\001\036\005 )0.6(\024\023\031\b\024\035\017 )0.5(\024\023\030\036\007\036)]TJ 0 Tw (-)Tj 0.671 Tw T* [(\035\016\033\021\f\016 )0.6(\017\255\016\r\035\036\027\017\036, )0.5(\001\036\030\024\b\024\r\026\021\024\f\021\034, )0.5(\027\036\030\024\r\027\024\f\021\034 )]TJ 0.35 Tw T* (\f\021\036\027\022\017 \017\035\017 \024\f\021\026\021\024\004\027\026\016\ \024\023\031\b\024\035\034, \220\021\024 \016\r\035\016\036\021\f\016 \024\ \f)Tj 0 Tw (-)Tj 0.252 Tw T* (\027\024\r\026\027\017\036\n \022)Tj /Span<>> BDC ( )Tj EMC (\021\024\n\031, \004\021\024\002\t, \022\026\022 \n\017\027\017\n\031\n,\ \031\f\024\n\027\017\021\034\f\016 )Tj 0.261 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (cCR. \224\027\007\024\f\022\024\023\017\004\036\f\022\017\005 \n\036\021\ \024\007, \023\024)Tj /Span<>> BDC ( )Tj EMC (\007\026\027\027\t\n \n\027\024\020\017\b )Tj 0.289 Tw T* [(\017\f\f\035\036\007\024\r\026\021\036\035\036\005, )0.6(\016\r\035\016\036\021\f\016 )0.6(\002\024\035\036\036 )0.5(\r\026\032\027\t\n )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 19.196 0 Td (\024\006\036\027\022\036 )Tj 0.098 Tw -19.196 -1.218 Td (\r\027\031\021\030\017\023\030\024\f\r\036\021\027\024\020\024 \022\024\n\ \023\024\027\036\027\021\026 \024\023\031\b\024\035\017, \021.\022. \204\ \217\230 \027\036 )Tj 0.027 Tw T* (\023\024\r\024\035\016\036\021 \007\017\235\235\036\030\036\027\006\017\ \030\024\r\026\021\034 \027\036\027\026\004\017\021\036\035\034\027\t\036\ \017\n\036)Tj 0 Tw (-)Tj 0.061 Tw T* (\027\036\027\017\016 \f\035\017\017\f\021\024\005 \024\002\024\035\024\004\ \022\017, \021\026\022\017\036 \022\026\022 \023\024\r\036\030\b\027\024\ \f\021\027\026\016 )Tj -0.042 Tw T* (\016\r\026, \024\f\021\026\021\024\004\027\026\016 \026\007\036\027\024\ \n\026\021\024\027\026\016 \017\035\017 \007\026\032\036 \024\023\031\b\ \024\035\036\r\026\016 )Tj 0.215 Tw T* (\021\022\026\027\034 [5,11,23,24]. \025\024\035\024\027\024\f\022\024\023\ \017\016 \f)Tj /Span<>> BDC ( )Tj EMC (\235\024\021\024\235\017\022\f\026\006\017\036\005 )Tj 0.333 Tw T* (\(\007\035\016 \023\024\f\035\036\007\031\033\013\036\020\024 \f\030\026\ \r\027\036\027\017\016 \r)Tj /Span<>> BDC ( )Tj EMC (\f\035\031\004\026\036 \023\030\017\027\016\021\017\016 )Tj 0.048 Tw T* (\030\036\001\036\027\017\016 \024)Tj /Span<>> BDC ( )Tj EMC (\027\026\002\035\033\007\036\027\017\017 \026)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\n\) \f\036\020\024\007\027\016 \016\r\035\ \016)Tj 0 Tw (-)Tj 0.151 Tw T* (\036\021\f\016 \027\026\017\002\024\035\036\036 \027\026\004\017\n\t\n \ \n\036\021\024\007\024\n \007\017\026\020\027\024\f\021\017\022\017 cCR.\ )Tj -0.018 Tw T* (\200\n\036\f\021\036 \f)Tj /Span<>> BDC ( )Tj EMC (\021\036\n, \204\217\230 \f)Tj /Span<>> BDC ( )Tj EMC (\017\f\023\024\035\034\024\r\026\027\017\036\n \f\024\r\030\036\n\036\027\ \027\t\b \030\036)Tj 0 Tw (-)Tj 0.118 Tw T* [(\032\017\n\024\r )0.5(\023\030\036\007\024\f\021\026\r\035\016\036\021 )0.6(\007\024\023\024\035\027\017\021\036\035\034\027\031\033 )0.6(\017\027\235\024\030\n\026\006\017\033 )]TJ -0.022 Tw T* (\024)Tj /Span<>> BDC ( )Tj EMC (\f\024\f\021\024\016\027\017\017 \f\021\036\027\022\017 \022\017\001\022\ \017, \030\036\020\017\024\027\026\035\034\027\t\b \035\017\n\235\026\021\ \017\004\036)Tj 0 Tw (-)Tj -0.005 Tw T* (\f\022\017\b \031\035\024\r. \206\024\r\024\030\017\021\034 \024)Tj /Span<>> BDC ( )Tj EMC (cCR \n\024\032\027\024 \021\024\035\034\022\024 \r)Tj /Span<>> BDC ( )Tj EMC (\021\036\b \f\035\031\004\026)Tj 0 Tw (-)Tj 0.019 Tw T* (\016\b, \022\024\020\007\026 \027\036\021 \023\030\017\027\026\022\024\r\ \024\f\021\026\021\024\004\027\024\005 \024\023\031\b\024\035\017 \r)Tj /Span<>> BDC ( )Tj EMC (\f\021\036\027\022\036 )Tj 0.2 Tw T* (\022\017\001\022\017, \017)Tj /Span<>> BDC ( )Tj EMC (\024\021\f\031\021\f\021\r\031\033\021 \007\026\027\027\t\036 \024)Tj /Span<>> BDC ( )Tj EMC (\023\024\030\026\032\036\027\017\017 \035\017\n\235\026)Tj 0 Tw (-)Tj 0.085 Tw T* (\021\017\004\036\f\022\017\b \031\035\024\r \n\036\024\030\036\022\021\ \031\n\026 [25]. \200)Tj /Span<>> BDC ( )Tj EMC (\023\024\f\035\036\007\027\017\036 \020\024\007\t )Tj 0.059 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\024\006\036\027\022\031 \204\217\230 \r\027\036\f\036\027\t \017\n\036\ \027\036\027\017\016, \f\024\020\035\026\f\027\024 \022\024\021\024\030\t\ \n )Tj 0.092 Tw T* (\022)Tj /Span<>> BDC ( )Tj EMC [(\f\035\031\004\026\016\n cCR )0.5(\024\021\027\024\f\016\021 )0.5(mrTRG1 \017)]TJ /Span<>> BDC ( )Tj EMC 13.931 0 Td [(\021\024\035\034\022\024 )0.5(\021\036 \r\026\030\017\026\027\021\t )]TJ 0.057 Tw -13.931 -1.218 Td (mrTRG2, \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\022\024\021\024\030\t\b \024\023\030\036\007\036\035\016\036\021\f\016 \ \f\017\n\023\021\024\n \253\030\026\f\013\036)Tj 0 Tw (-)Tj 0.012 Tw T* [(\023\035\036\027\027\024\020\024 \030\031\002\006\026\273. \216\026\030\026\ \022\021\036\030\027\t\n\017 )0.5(\023\030\017\027\026\022\026\n\017 \023\024\f\035\036\007)]TJ 0 Tw (-)Tj -0.01 Tw T* (\027\036\020\024 \016\r\035\016\036\021\f\016, \023\024\n\017\n\024 \021\ \024\027\022\024\020\024 \030\031\002\006\026 \023\024)Tj /Span<>> BDC ( )Tj EMC (\r\027\031\021\030\036\027\027\036\n\031 )Tj 0.116 Tw T* (\022\024\027\021\031\030\031, \027\026\035\017\004\017\036 \235\017\002\030\ \024\027\024\020\024 \030\031\002\006\026 \030\026\035\017\004\027\024\ \005 \021\024\035)Tj 0 Tw (-)Tj T* (\013\017\027\t \023\024)Tj /Span<>> BDC ( )Tj EMC (\027\026\030\031\032\027\024\n\031 \022\024\027\021\031\030\031 [26].)Tj 0.117 Tw T* (\215\030\024\002\035\036\n\026 cCR \026\022\035\033\004\026\036\021\f\016\ \r)Tj /Span<>> BDC ( )Tj EMC (\021\024\n, \004\021\024 \023\024\004\021\017 \031)Tj /Span<>> BDC ( )Tj EMC (\023\024\035\024)Tj 0 Tw (-)Tj 0.142 Tw T* (\r\017\027\t \023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (cCR \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\017\f\f\035\036\007\024\r\026\027\017\017 \031\007\026\035\036\027\027\024\ )Tj 0 Tw (-)Tj 0.236 Tw T* [(\020\024 )0.5(\023\030\036\023\026\030\026\021\026 )0.5(\r\t\016\r\035\016\036\021\f\016 )0.6(\024\f\021\026\021\024\004\027\026\016 )0.6(\024\023\031\b\024\035\034 )0.5([27]. )]TJ 0.01 Tw T* (\200)Tj /Span<>> BDC ( )Tj EMC (\027\026\001\036\n \017\f\f\035\036\007\024\r\026\027\017\017 \031)Tj /Span<>> BDC ( )Tj EMC (2 \017)Tj /Span<>> BDC ( )Tj EMC (5 \023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (cCR \002\t\035\026 )Tj -0.001 Tw T* (\024\f\021\026\021\024\004\027\026\016 \024\023\031\b\024\035\034 \023\024\ )Tj /Span<>> BDC ( )Tj EMC (\007\026\027\027\t\n \023\026\021\024\n\024\030\235\024\035\024\020\017\004\ \036\f\022\024)Tj 0 Tw (-)Tj 0.068 Tw T* (\020\024 \017\f\f\035\036\007\024\r\026\027\017\016. \215\030\017\004\017\ \027\024\005 \220\021\024\020\024 \016\r\035\016\036\021\f\016 \235\036\027\ \024\n\036\027 )Tj 0.168 Tw T* [(\235\030\026\020\n\036\027\021\026\006\017\017 )0.6(\024\023\031\b\024\035\017 )0.5(\r\f\035\036\007\f\021\r\017\036 )0.6(\214\230, )0.5(\023\030\017)]TJ /Span<>> BDC ( )Tj EMC 18.696 0 Td (\022\024\021\024\030\024\n )Tj 0.16 Tw -18.696 -1.218 Td (\027\036\022\030\024 \024\023\031\b\024\035\017 \017)Tj /Span<>> BDC ( )Tj EMC (\036\036 \f\024\022\030\026\013\036\027\017\036 \023\030\024\017\f\b\024\ \007\017\021 \027\036 \024\021 )Tj 0.033 Tw T* (\023\036\030\017\235\036\030\017\017 \022)Tj /Span<>> BDC ( )Tj EMC (\006\036\027\021\030\031 \017\035\017 \024\021 \n\036\024\030\036\022\021\ \031\n\026 \022)Tj /Span<>> BDC ( )Tj EMC (\f\035\017\017\f\021\024\005 )Tj 0.06 Tw T* (\024\002\024\035\024\004\022\036, \026)Tj /Span<>> BDC ( )Tj EMC (\023\024\r\f\036\n\036\f\021\027\024 \r)Tj /Span<>> BDC ( )Tj EMC (\024\023\031\b\024\035\017, \023\030\017\r\024\007\016 \022)Tj /Span<>> BDC ( )Tj EMC (\024\002\030\026)Tj 0 Tw (-)Tj -0.001 Tw T* (\024\r\026\027\017\033 \n\036\035\022\017\b \f\022\024\023\035\036\027\017\ \005 \024\023\031\b\024\035\036\r\t\b \022\035\036\021\024\022 \r)Tj /Span<>> BDC ( )Tj EMC (\030\026)Tj 0 Tw (-)Tj 0.193 Tw T* (\027\t\b \004\026\f\021\016\b \035\024\032\026 \024\023\031\b\024\035\017\ [23,27,28]. \205\030\026\020\n\036\027\021\026\006\017\016 )Tj 0.199 Tw T* (\024\023\031\b\024\035\017 \r\f\021\030\036\004\026\036\021\f\016 \r)Tj /Span<>> BDC ( )Tj EMC (40\22680% \f\035\031\004\026\036\r \017)Tj /Span<>> BDC ( )Tj EMC (\016\r\035\016\036\021\f\016 )Tj 0.219 Tw T* (\024\f\027\024\r\027\024\005 \023\030\017\004\017\027\024\005 \n\036\f\021\ \027\t\b \030\036\006\017\007\017\r\024\r \023\024\f\035\036 \230\224\204\ )Tj 0.043 Tw T* (\023\030\017)Tj /Span<>> BDC ( )Tj EMC (\023\024\035\027\024\n \023\026\021\024\n\024\030\235\024\035\024\020\017\ \004\036\f\022\024\n \024\021\r\036\021\036 [23,27,28]. )Tj 0.308 Tw T* (\210\007\027\026\022\024, \027\036\f\n\024\021\030\016 \027\026)Tj /Span<>> BDC ( )Tj EMC (\r\t\f\024\022\031\033 \004\026\f\021\024\021\031 \023\024\r\021\024\030\ \027\024\020\024 )Tj 0.029 Tw T* (\030\024\f\021\026 \024\023\031\b\024\035\017 \023\024\f\035\036 \230\224\ \204 \(22\22625%\), \002\024\035\036\036 \004\036\n \031)Tj /Span<>> BDC ( )Tj EMC (90% )Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0 Tw 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\033\030\031\030\213\b)-20.9(\035\231\213\233\t \021\032)50(\b)42(\032\231\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj -51.938 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 23, \023\0221)69(, 202)69(4)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 23, \023\0221)69(, 202)69(4)]TJ /T1_3 1 Tf 25 0 0 25 28.14 56.0378 Tm (86)Tj ET endstream endobj 1473 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1474 0 obj <>/ExtGState<>/Font<>/ProcSet[/PDF/Text]/Properties<>/Shading<>/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1475 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1476 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1477 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1721 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\032)30(\002\013\001\006\013\001\013\007\216\001\020\016 \232\001\201\025\024\220\ \n\002\025\207\220\002\215\002\202\220\017\016\006\n\220\016 \r\024\016\ \013\026)11(\016\007\216\006)-10(\026\r\013 )]TJ 0 -1 TD [(\221\002\220\022\002\013\n\016 \221\002\205\024\025\203 \n\220\n\220 \221\ \025\006)-10(\007\016 \007\215\017\016\r\025\203 \220\007\220 )]TJ T* [(\207\220\024\220\025\007\215\017\016\r\025\203 \026)11(\016\002\013\221\220\220\022\236 \001\212\013\001\006\020 \220\022\002\016\ \222)21.1(\215\007\216)21(\026)11(\013\026\020)]TJ 32.955 2 Td [(T)20(r)21(ansanal endoscopic micr)20(osur)31(ger)-31(y af)-31(ter r)21(adiation or ch)11(emor)21(adiation )]TJ 7.251 -1 Td [(th)11(er)21(apy for r)31(ectal cancer\022\236 peculiarities and r)31(esults)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0.067 Tw 10 0 0 10 42.5197 578.6938 Tm (\023\030\036\007\035\024\032\036\027\024 \r\t\023\024\035\027\036\027\017\ \036 \021\024\021\026\035\034\027\024\005 \n\036\024\030\036\022\021\031\ \n\220\022\021\024)Tj 0 Tw (-)Tj 0.048 Tw 0 -1.218 TD (\n\017\017 \(\230\204\224\), \027\024 \r\r\017\007\031 \r\t\030\026\032\036\ \027\027\024\005 \f\024\023\031\021\f\021\r\031\033\013\036\005 \023\026\ )Tj 0 Tw (-)Tj -0.004 Tw T* (\021\024\035\024\020\017\017, \f\021\026\030\004\036\f\022\024\020\024 \r\ \024\030\026\f\021\026 \017\035\017 \032\036\035\026\027\017\016 \023\026\ \006\017\036\027\021\026 )Tj 0.045 Tw 0 -1.218 TD (\f\024\b\030\026\027\017\021\034 \024\030\020\026\027, \023\026\006\017\036\ \027\021\t \024\021\022\026\026\035\017\f\034 \024\021 \b\017\030\031\030\ \020\017\004\036)Tj 0 Tw (-)Tj 0.161 Tw 0 -1.218 TD (\f\022\024\020\024 \035\036\004\036\027\017\016 \r)Tj /Span<>> BDC ( )Tj EMC (\024\002\255\036\n\036 \030\036\036\022\006\017\017 \017\035\017 \220\022\ \f\021\017\030\023\026\006\017\017 )Tj 0 Tw 0 -1.218 TD (\023\030\016\n\024\005 \022\017\001\022\017.)Tj 0.029 Tw 0 -1.218 TD (\204\036\021\024\007\017\022\026 \r\t\023\024\035\027\036\027\017\016 \230\ \224\204 \023\024\007\030\026\031\n\036\r\026\035\026 \023\024\007 \f\024\ \002\024\005 )Tj 0.106 Tw 0 -1.218 TD (\n\026\030\022\017\030\024\r\022\031 \f\035\017\017\f\021\024\005 \027\026\ )Tj /Span<>> BDC ( )Tj EMC (\030\026\f\f\021\024\016\027\017\017 10)Tj /Span<>> BDC ( )Tj EMC (\n\n \024\021 \022\030\026\016 )Tj 0.301 Tw 0 -1.218 TD (\024\023\031\b\024\035\017, \f)Tj /Span<>> BDC ( )Tj EMC [(\007\026\035\034\027\036\005\001\017\n \023\024\035\027\024\f\021\036\027\ \027\t\n )0.5(\017\f\f\036\004\036\027\017\036\n )]TJ 0.129 Tw T* (\027\024\r\024\024\002\030\026\024\r\026\027\017\016 \r)Tj /Span<>> BDC ( )Tj EMC [(\023\030\036\007\036\035\026\b \r\017\031\026\035\034\027\024 )0.5(\027\036\017\n\036\027\201\027)]TJ 0 Tw (-)Tj 0.126 Tw T* (\027\024\005 \f\035\017\017\f\021\024\005 \007\024)Tj /Span<>> BDC ( )Tj EMC (\023\026\030\026\030\036\022\021\026\035\034\027\024\005 \022\035\036\021\ \004\026\021\022\017 \017)Tj /Span<>> BDC ( )Tj EMC (\031\001\017)Tj 0 Tw (-)Tj T* (\r\026\027\017\036\n \007\036\235\036\022\021\026 \022\017\001\022\017 \r\ )Tj /Span<>> BDC ( )Tj EMC (\023\024\023\036\030\036\004\027\024\n \027\026\023\030\026\r\035\036\027\ \017\017.)Tj -0.055 Tw T* (\212\035\016 \f\021\026\021\017\f\021\017\004\036\f\022\024\005 \024\002\ \030\026\002\024\021\022\017 \017\f\023\024\035\034\024\r\026\035\017 \022\ \024\n\n\036\030)Tj 0 Tw (-)Tj 0.043 Tw T* [(\004\036\f\022\017\036 \002\017\024\n\036\007\017\006\017\027\f\022\017\036\ \023\026\022\036\021\t P)35(r)-36.9(is)26(m 3.1 \017)]TJ /Span<>> BDC ( )Tj EMC [(IBM SPS)17.1(S )]TJ 0.301 Tw T* [(S)15(t)15(a)15(t)-32(ist)-32(ics 23.0.0.0. \202\027\026\035\017 \r\t\032\017\r\026\036\n\024\f\021\017\ \002\024\035\034\027\t\b )]TJ 0.032 Tw T* (\023\030\024\017\r\024\007\017\035\017 \023\024)Tj /Span<>> BDC ( )Tj EMC [(\n\036\021\024\007\031 K)-16(apl)-16(an-Meier. \212\035\016 \f\030\026\r\027\036\027\017\016 )]TJ 0.24 Tw T* (\022\030\017\r\t\b \r\t\032\017\r\026\036\n\024\f\021\017 \017\f\023\024\ \035\034\024\r\026\035\017 \035\024\020\026\030\017\235\n\017\004\036)Tj 0 Tw (-)Tj 0.003 Tw T* (\f\022\017\005 \030\026\027\020\024\r\t\005 \022\030\017\021\036\030\017\ \005. \210\006\036\027\022\031 \r\t\032\017\r\026\036\n\024\f\021\017 \023\ \030\024)Tj 0 Tw (-)Tj 0.001 Tw T* (\r\024\007\017\035\017 \023\024)Tj /Span<>> BDC ( )Tj EMC (3-\035\036\021\027\017\n \023\024\022\026\026\021\036\035\016\n. \215\030\ \017)Tj /Span<>> BDC ( )Tj EMC (\030\026\f\004\036\021\036 \024\002\013\036\005 )Tj -0.004 Tw T* [(\r\t\032\017\r\026\036\n\024\f\021\017 \253\f\024\002\t\021\017\036\n\273\ )0.5(\f\004\017\021\026\035\017 \f\n\036\030\021\034 \023\026\006\017\036\027\ \021\026. )]TJ 0.024 Tw T* (\215\030\017)Tj /Span<>> BDC ( )Tj EMC (\030\026\f\004\036\021\036 \002\036\030\036\006\017\007\017\r\027\024\005\ \r\t\032\017\r\026\036\n\024\f\021\017 \253\f\024\002\t\021\017)Tj 0 Tw (-)Tj 0.144 Tw T* [(\036\n\273 )0.5(\f\004\017\021\026\035\017 )0.6(\n\036\f\021\027\t\005 )0.5(\030\036\006\017\007\017\r, )0.5(\024\021\007\026\035\036\027\027\024\036 )0.6(\n\036\021\026\f\021\026)]TJ 0 Tw (-)Tj T* (\017\030\024\r\026\027\017\036 \017\035\017 \f\n\036\030\021\034 \023\026\ \006\017\036\027\021\026 \024\021 \035\033\002\024\005 \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\017\004\017\027.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 42.5896 274.2438 Tm [(\033\034\020)21(\223)50(\r\241)46(\024)52(\026)45(\024\232)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0 Tc 0.35 Tw 10 0 0 10 42.5197 249.8878 Tm (\215\030\024\007\024\035\032\017\021\036\035\034\027\024\f\021\034 \b\017\ \030\031\030\020\017\004\036\f\022\024\020\024 \r\n\036\001\026\021\036\035\ \034\f\021\r\026 )Tj 0.081 Tw T* (\022\024\035\036\002\026\035\026\f\034 \024\021 40 \007\024)Tj /Span<>> BDC ( )Tj EMC (210 \n\017\027\031\021 \(\n\036\007\017\026\027\026)Tj /Span<>> BDC ( )Tj EMC (\227 117)Tj /Span<>> BDC ( )Tj EMC (\n\017)Tj 0 Tw (-)Tj -0.069 Tw T* (\027\031\021\). \210\002\255\036\n \022\030\024\r\024\023\024\021\036\030\ \017 \027\036 \023\030\036\r\t\001\026\035 40 \n\035. \204\036\007\017\026\ \027\026 )Tj 0.082 Tw T* (\007\035\017\021\036\035\034\027\024\f\021\017 \023\024\f\035\036\024\023\ \036\030\026\006\017\024\027\027\024\020\024 \022\024\005\022\024-\007\027\ \016 \f\024\f\021\026)Tj 0 Tw (-)Tj T* (\r\017\035\026 5 \(3\22625\) \007\027\036\005.)Tj 0.121 Tw T* [(\210\f\035\024\032\027\036\027\027\024\036 )0.6(\021\036\004\036\027\017\036 )0.5(\023\024\f\035\036\024\023\036\030\026\006\017\024\027\027\024\020\024 )0.5(\023\036\030\017\024\007\026 )]TJ 0.209 Tw T* (\027\026\002\035\033\007\026\035\024\f\034 \031)Tj /Span<>> BDC ( )Tj EMC (4)Tj /Span<>> BDC ( )Tj EMC (\(20,0%\) \002\024\035\034\027\t\b. \223\026\013\036 \r\f\036\020\024 \024\ \021)Tj 0 Tw (-)Tj 0.191 Tw T* (\n\036\004\026\035\017\f\034 \024\f\035\024\032\027\036\027\017\016 I \f\ \021\036\023\036\027\017 \023\024)Tj /Span<>> BDC ( )Tj EMC (\022\035\026\f\f\017\235\017\022\026\006\017\017 )Tj 0.25 Tw T* [(Cl)-16(av)-15.9(ien-Dind)-16(o, \023\024\007\030\026\031\n\036\r\026\033\013\017\036 \023\024\007 \f\ \024\002\024\005 \035\033\002\t\036 )]TJ 0.554 Tw T* (\024\021\022\035\024\027\036\027\017\016 \024\021 \027\024\030\n\026\035\ \034\027\024\020\024 \023\024\f\035\036\024\023\036\030\026\006\017\024\027\ \027\024\020\024 )Tj 0.115 Tw T* (\023\036\030\017\024\007\026, \r)Tj /Span<>> BDC ( )Tj EMC (\021\024\n \004\017\f\035\036 \035\017\b\024\030\026\007\022\026 \017\035\ \017 \027\036\024\002\b\024\007\017\n\024\f\021\034 )Tj 0.388 Tw T* (\f\n\036\027\t \035\036\022\026\030\f\021\r\036\027\027\024\005 \021\036\ \030\026\023\017\017. \203\036\f\024\f\021\024\016\021\036\035\034\027\024\ \f\021\034 )Tj 0.446 Tw T* (\001\r\024\r \031\001\017\021\024\020\024 \007\036\235\036\022\021\026 \022\ \017\001\022\017 \002\t\035\026 \031\f\021\026\027\024\r\035\036\027\026\ )Tj 0.033 Tw T* (\031)Tj /Span<>> BDC ( )Tj EMC 0.71 0 Td (3)Tj /Span<>> BDC ( )Tj EMC 0.765 0 Td [(\(15,0%\) )0.5(\023\026\006\017\036\027\021\024\r )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC 8.82 0 Td [(\023\024\021\030\036\002\024\r\026\035\026 )0.5(\023\024\r\021\024\030\027\024\020\024 )0.6(\b\017)]TJ 0 Tw (-)Tj 0.043 Tw -10.296 -1.218 Td (\030\031\030\020\017\004\036\f\022\024\020\024 \r\n\036\001\026\021\036\035\ \034\f\021\r\026 \r)Tj /Span<>> BDC ( )Tj EMC (\024\007\027\024\n \f\035\031\004\026\036)Tj /Span<>> BDC ( )Tj EMC (\227 5,0% )Tj 0.056 Tw 23.244 49.93 Td [(\(Cl)-16(av)-15.9(ien-Dind)-16(o 3 \f\021\036\023\036\027\017\), \004\021\024 \f\024\023\024\f\021\026\r\ \017\n\024 \f)]TJ /Span<>> BDC ( )Tj EMC (\007\026\027\027\t)Tj 0 Tw (-)Tj 0.118 Tw T* (\n\017 \026\030\031\002\036\032\027\t\b \030\026\002\024\021, \r)Tj /Span<>> BDC ( )Tj EMC (\004\026\f\021\027\024\f\021\017 \f)Tj /Span<>> BDC ( )Tj EMC (\017\f\f\035\036\007\024\r\026\027\017\036\n )Tj 0.069 Tw T* [(T)35(A)17(U-TEM [20]. \210\f\035\024\032\027\036\027\017\016 IV \017)]TJ /Span<>> BDC ( )Tj EMC (V \f\021\036\023\036\027\017, \021\026\022\017\036 \022\026\022 )Tj 0.303 Tw T* [(\023\024\035\017\024\030\020\026\027\027\026\016 \027\036\007\024\f\021\026\ \021\024\004\027\024\f\021\034 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC (\f\n\036\030\021\034 \023\026\006\017\036\027\021\026, )Tj 0 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\017\f\f\035\036\007\024\r\026\027\017\017 \024\021\n\036\004\036\027\t \ \027\036 \002\t\035\017.)Tj 0.28 Tw T* (\215\030\017 \023\026\021\024\n\024\030\235\024\035\024\020\017\004\036\f\ \022\024\n \017\f\f\035\036\007\024\r\026\027\017\017 \017)Tj /Span<>> BDC ( )Tj EMC (5 \023\026)Tj 0 Tw (-)Tj 0.242 Tw T* (\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (cCR \022\026\021\036\020\024\030\017\016 \024\023\031\b\024\035\017 ypT0\ \002\t\035\026 \031\f\021\026)Tj 0 Tw (-)Tj 0.599 Tw T* (\027\024\r\035\036\027\026 \r)Tj /Span<>> BDC ( )Tj EMC (3 \f\035\031\004\026\016\b \(\023\026\021\024\n\024\030\235\024 IV \f\021\ \036\023\036\027\017 )Tj 0.126 Tw T* (\023\024)Tj /Span<>> BDC ( )Tj EMC (\214\026\r\027\017\022\024\r\024\005)Tj /Span<>> BDC ( )Tj EMC [(\206.\202., C)20(AP)]TJ /Span<>> BDC ( )Tj EMC (\227 0\), \r)Tj /Span<>> BDC ( )Tj EMC (\024\007\027\024\n)Tj /Span<>> BDC ( )Tj EMC [(\227 ypT1s)26(m1 )]TJ 0.043 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\r)Tj /Span<>> BDC ( )Tj EMC (\036\013\036 \024\007\027\024\n)Tj /Span<>> BDC ( )Tj EMC (\227 ypT3 \022\026\021\036\020\024\030\017\016. \200)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \f)Tj /Span<>> BDC ( )Tj EMC (nCR \022\026)Tj 0 Tw (-)Tj 0.083 Tw T* (\021\036\020\024\030\017\016 ypT \002\t\035\026 \023\030\036\007\f\021\026\ \r\035\036\027\026 ypT0)Tj /Span<>> BDC ( )Tj EMC (\227 \r)Tj /Span<>> BDC ( )Tj EMC (3 \f\035\031\004\026\016\b, )Tj -0.07 Tw T* [(ypT)35(is)]TJ /Span<>> BDC ( )Tj EMC (\227 \r)Tj /Span<>> BDC ( )Tj EMC [(3, ypT1s)26(m1)]TJ /Span<>> BDC ( )Tj EMC (\227 \r)Tj /Span<>> BDC ( )Tj EMC [(2, ypT1s)26(m2)]TJ /Span<>> BDC ( )Tj EMC (\227 \r)Tj /Span<>> BDC ( )Tj EMC [(2, ypT1s)26(m3)]TJ /Span<>> BDC ( )Tj EMC (\227 )Tj 0 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (2, ypT2)Tj /Span<>> BDC ( )Tj EMC (\227 \r)Tj /Span<>> BDC ( )Tj EMC (2, ypT3)Tj /Span<>> BDC ( )Tj EMC (\227 \r)Tj /Span<>> BDC ( )Tj EMC (1 \f\035\031\004\026\036 \(\230\026\002\035.)Tj /Span<>> BDC ( )Tj EMC (1\).)Tj 0.059 Tw T* (\203\036\002\035\026\020\024\023\030\017\016\021\027\t\036 \235\026\022\021\ \024\030\t \023\030\024\020\027\024\026 \002\t\035\017 \r\t\016\r\035\036\ \027\t )Tj 0.105 Tw T* (\031)Tj /Span<>> BDC ( )Tj EMC (7)Tj /Span<>> BDC ( )Tj EMC (\(35%\) \023\026\006\017\036\027\021\024\r: \r\024\r\035\036\004\036\027\ \017\036 \037\206\217)Tj /Span<>> BDC ( )Tj EMC (\227 \031)Tj /Span<>> BDC ( )Tj EMC (1)Tj /Span<>> BDC ( )Tj EMC (\(5,0%\) )Tj 0.004 Tw T* [(\002\024\035\034\027\024\020\024, )0.5(T1s)26(m3 )0.5(\023\030\017)]TJ /Span<>> BDC ( )Tj EMC 8.762 0 Td [(\024\023\031\b\024\035\016\b )0.6(\f)]TJ /Span<>> BDC ( )Tj EMC 4.691 0 Td [(\017\027\r\026\017\036\005 )0.6(\r)]TJ /Span<>> BDC ( )Tj EMC 4.843 0 Td (\023\030\036\007\036\035\026\b )Tj 0.05 Tw -18.296 -1.218 Td (\023\024\007\f\035\017\017\f\021\024\020\024 \f\035\024\016)Tj /Span<>> BDC ( )Tj EMC (\227 \031)Tj /Span<>> BDC ( )Tj EMC (2)Tj /Span<>> BDC ( )Tj EMC (\(10,0%\) \002\024\035\034\027\t\b, \017\027\r\026\017\016 )Tj 0.104 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\n\t\001\036\004\027\t\005 \f\035\024\005)Tj /Span<>> BDC ( )Tj EMC (\227 \031)Tj /Span<>> BDC ( )Tj EMC (2)Tj /Span<>> BDC ( )Tj EMC (\(10,0%\), \r)Tj /Span<>> BDC ( )Tj EMC (\n\036\024\030\036\022\021\026\035\034\027\031\033 )Tj 0.201 Tw T* (\022\035\036\021\004\026\021\022\031)Tj /Span<>> BDC ( )Tj EMC (\227 \031)Tj /Span<>> BDC ( )Tj EMC (2 \023\026\006\017\036\027\021\024\r \017)Tj /Span<>> BDC ( )Tj EMC (\036\013\036 \r)Tj /Span<>> BDC ( )Tj EMC (\024\007\027\024\n \f\035\031\004\026\036 )Tj 0.143 Tw T* (\027\024\r\024\024\002\030\026\024\r\026\027\017\036 \002\t\035\024 \023\ \030\036\007\f\021\026\r\035\036\027\024 \f)Tj /Span<>> BDC ( )Tj EMC (\017\027\r\026\017\r\027\t\n )Tj 0.384 Tw T* [(\030\024\f\021\024\n \n\031\006\017\027\024\027\024\005 )0.5(\026\007\036\027\024\022\026\030\006\017\027\024\n\t. \200\f\036\n \023\026\ \006\017)]TJ 0 Tw (-)Tj 0.112 Tw T* (\036\027\021\026\n \002\t\035\017 \023\030\036\007\035\024\032\036\027\t\ \026\r\036\030\001\026\033\013\017\036 \230\204\224. \210\007\027\026\022\ \024 )Tj 0.136 Tw T* (\r\f\036\020\024 \026\r\036\030\001\026\033\013\026\016 \021\024\021\026\ \035\034\027\026\016 \230\204\224 \002\t\035\026 \r\t\023\024\035\027\036\ \027\026 )Tj 0.056 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (2 \017)Tj /Span<>> BDC ( )Tj EMC (7)Tj /Span<>> BDC ( )Tj EMC (\(28,6%\) \f\035\031\004\026\016\b)Tj /Span<>> BDC ( )Tj EMC (\227 \031)Tj /Span<>> BDC ( )Tj EMC (\024\007\027\024\005 \023\026\006\017\036\027\021\022\017 \002\t\035\017\ )Tj 0.143 Tw T* [(\r\t\016\r\035\036\027\t )0.6(\f\030\026\031 )0.5(\007\r\026 )0.5(\027\036\002\035\026\020\024\023\030\017\016\021\027\t\b )0.6(\235\026\022\021\024\030\026 )0.6(\(\017\027)]TJ 0 Tw (-)Tj 0.071 Tw T* [(\r\026\017\016 \024\023\031\b\024\035\017 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC [(\n\036\024\030\036\022\021\026\035\034\027\031\033 )0.5(\022\035\036\021\004\026\021\022\031 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC (\027\036\002\035\026)Tj 0 Tw (-)Tj 0.22 Tw T* (\020\024\023\030\017\016\021\027\t\005 \020\017\f\021\024\035\024\020\017\ \004\036\f\022\017\005 \021\017\023 \024\023\031\b\024\035\017\), \r\024\ \r\021\024)Tj 0 Tw (-)Tj 0.088 Tw T* (\030\024\n \f\035\031\004\026\036)Tj /Span<>> BDC ( )Tj EMC (\227 ypT3 \022\026\021\036\020\024\030\017\016 \024\023\031\b\024\035\017\ . \200)Tj /Span<>> BDC ( )Tj EMC (\024\f\021\026\035\034\027\t\b )Tj 0.199 Tw T* (\022\035\017\027\017\004\036\f\022\017\b \f\017\021\031\026\006\017\016\b\ , \r\r\017\007\031 \024\021\022\026\026 \023\026\006\017\036\027\021\024\ \r \024\021 )Tj 0.027 Tw T* (\026\r\036\030\001\026\033\013\036\005 \230\204\224, \023\030\024\r\024\ \007\017\035\024\f\034 \026\022\021\017\r\027\024\036 \007\017\027\026\n\ \017\004\036)Tj 0 Tw (-)Tj 0.03 Tw T* (\f\022\024\036 \027\026\002\035\033\007\036\027\017\036. \203\017 \r)Tj /Span<>> BDC ( )Tj EMC (\024\007\027\024\n \f\035\031\004\026\036 \n\036\f\021\027\024\020\024 \030\ \036\006\017)Tj 0 Tw (-)Tj 0.117 Tw T* [(\007\017\r\026 )0.5(\024\023\031\b\024\035\017 )0.6(\023\030\017)]TJ /Span<>> BDC ( )Tj EMC 7.902 0 Td [(\007\017\027\026\n\017\004\036\f\022\024\n )0.5(\027\026\002\035\033\007\036\027\017\017 )0.6(\r\t\016\r)]TJ 0 Tw (-)Tj -7.902 -1.218 Td (\035\036\027\024 \027\036 \002\t\035\024.)Tj 0.573 Tw T* [(\215\030\017 )0.5(\n\036\007\017\026\027\036 )0.6(\027\026\002\035\033\007\036\027\017\016 )0.6(31,5 )0.5(\(3\22654\) )0.5(\n\036\f\016\006\036\r )]TJ 0.983 Tw T* (\024\021\007\026\035\036\027\027\t\036 \n\036\021\026\f\021\026\t \002\t\ \035\017 \007\017\026\020\027\024\f\021\017\030\024\r\026\027\t )Tj 0.06 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (2)Tj /Span<>> BDC ( )Tj EMC (\(10,0%\))Tj /Span<>> BDC ( )Tj EMC (\f\035\031\004\026\016\b. \204\036\f\021\027\t\005 \030\036\006\017\007\017\ \r \027\026)Tj /Span<>> BDC ( )Tj EMC (\f\030\024\022\036 12,3 )Tj 0.061 Tw T* (\n\036\f\016\006\036\r \002\t\035 \r\t\016\r\035\036\027 \r)Tj /Span<>> BDC ( )Tj EMC (\024\007\027\024\n \f\035\031\004\026\036 \(5,0%\) \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017)Tj 0 Tw (-)Tj 0.201 Tw T* (\036\027\021\026 \f)Tj /Span<>> BDC ( )Tj EMC (ypT0 \(cT2\) \022\026\021\036\020\024\030\017\036\005 \024\023\031\b\024\ \035\017 \r)Tj /Span<>> BDC ( )Tj EMC (\f\024\004\036\021\026\027\017\017 )Tj -0.024 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\024\007\027\024\f\021\024\030\024\027\027\017\n \n\036\021\026\f\021\026\ \021\017\004\036\f\022\017\n \023\024\030\026\032\036\027\017\036\n \023\ \026\b\024)Tj 0 Tw (-)Tj -0.037 Tw T* [(\r\t\b )0.5(\035\017\n\235\026\021\017\004\036\f\022\017\b )0.6(\031\035\024\r )0.5(\(\030\026\f\006\036\027\036\027\024 )0.6(\022\026\022 )0.5(\024\021\007\026\035\036\027\027\024\036 )]TJ 0.062 Tw T* [(\n\036\021\026\f\021\026\017\030\024\r\026\027\017\036\). )0.5(\215\026\006\017\036\027\021\031 \002\t\035\026 \r\t\023\024\035\027\036\ \027\026 \035\026\023\026)]TJ 0 Tw (-)Tj 0.031 Tw T* (\030\024\f\022\024\023\017\004\036\f\022\026\016 \002\030\033\001\027\024\ -\023\030\024\n\036\032\027\024\f\021\027\026\016 \220\022\f\021\017\030\ \023\026\006\017\016 )Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0 Tw 9 0 0 9 42.5197 730.483 Tm (\020\004\206\f\t\204\004 1.)Tj 0 0 0 1 k /GS1 gs /T1_4 1 Tf ( \207\n\n\024\027\031\024\t\024\027\025\031 \013\023\025\021\025\006\031\ \t\013\n\202\n \025)Tj /Span<>> BDC ( )Tj EMC [(\033\026\024\n\003\n\032\f\n\023\n\202\025\006\031\t\013\n\202\n \t\024\026\ \030)0.5(\025\032\n\027\026\021\025\002 \005\n\023\022\021\020\004)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0 -1.2 TD [(T)48(able 1)47(.)]TJ 0 0 0 1 k /GS1 gs /T1_4 1 Tf [( Com)16.1(pliance of clinical and pathomor)-17.7(phological staging of patients)]TJ ET 0 0 0 1 K 0.5 w /GS2 gs q 1 0 0 1 42.5197 715.181 cm 0 0 m 90.959 0 l S Q q 1 0 0 1 42.7697 703.7118 cm 0 0 m 0 11.219 l S Q q 1 0 0 1 133.4783 715.181 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 133.4783 703.9618 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 178.8327 715.181 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 224.187 715.181 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 269.5413 715.181 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 314.8957 715.181 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 360.25 715.181 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 405.6043 715.181 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 450.9586 715.181 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 496.313 703.9618 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 42.7697 692.2426 cm 0 0 m 0 11.469 l S Q q 1 0 0 1 133.2283 703.7118 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 133.4783 692.4926 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 178.8327 703.7118 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 224.187 703.7118 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 269.5413 703.7118 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 314.8957 703.7118 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 360.25 703.7118 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 360.25 692.4926 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 405.6043 703.7118 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 450.9586 703.7118 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 496.313 692.4926 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 42.7697 681.0234 cm 0 0 m 0 11.219 l S Q q 1 0 0 1 133.2283 692.2426 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 133.4783 681.0234 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 178.8327 692.2426 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 178.8327 681.0234 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 224.187 692.2426 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 224.187 681.0234 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 269.5413 692.2426 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 269.5413 681.0234 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 314.8957 692.2426 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 314.8957 681.0234 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 360.25 692.2426 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 360.25 681.0234 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 405.6043 692.2426 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 405.6043 681.0234 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 450.9586 692.2426 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 450.9586 681.0234 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 496.313 681.0234 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 42.5197 680.7734 cm 0 0 m 90.959 0 l S Q q 1 0 0 1 42.7697 669.5541 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 133.4783 680.7734 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 133.4783 669.5541 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 178.8327 680.7734 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 178.8327 669.5541 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 224.187 680.7734 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 224.187 669.5541 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 269.5413 680.7734 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 269.5413 669.5541 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 314.8957 680.7734 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 314.8957 669.5541 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 360.25 680.7734 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 360.25 669.5541 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 405.6043 680.7734 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 405.6043 669.5541 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 450.9586 680.7734 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 450.9586 669.5541 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 496.313 669.5541 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 42.5197 669.3041 cm 0 0 m 90.959 0 l S Q q 1 0 0 1 42.7697 658.085 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 133.4783 669.3041 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 133.4783 658.085 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 178.8327 669.3041 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 178.8327 658.085 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 224.187 669.3041 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 224.187 658.085 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 269.5413 669.3041 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 269.5413 658.085 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 314.8957 669.3041 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 314.8957 658.085 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 360.25 669.3041 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 360.25 658.085 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 405.6043 669.3041 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 405.6043 658.085 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 450.9586 669.3041 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 450.9586 658.085 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 496.313 658.085 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 42.5197 657.835 cm 0 0 m 90.959 0 l S Q q 1 0 0 1 42.7697 646.6157 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 133.4783 657.835 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 133.4783 646.6157 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 178.8327 657.835 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 178.8327 646.6157 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 224.187 657.835 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 224.187 646.6157 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 269.5413 657.835 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 269.5413 646.6157 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 314.8957 657.835 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 314.8957 646.6157 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 360.25 657.835 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 360.25 646.6157 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 405.6043 657.835 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 405.6043 646.6157 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 450.9586 657.835 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 450.9586 646.6157 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 496.313 646.6157 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 42.5197 646.3657 cm 0 0 m 90.959 0 l S Q q 1 0 0 1 42.7697 635.1465 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 133.4783 646.3657 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 133.4783 635.1465 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 178.8327 646.3657 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 178.8327 635.1465 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 224.187 646.3657 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 224.187 635.1465 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 269.5413 646.3657 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 269.5413 635.1465 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 314.8957 646.3657 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 314.8957 635.1465 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 360.25 646.3657 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 360.25 635.1465 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 405.6043 646.3657 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 405.6043 635.1465 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 450.9586 646.3657 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 450.9586 635.1465 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 496.313 635.1465 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 42.5197 634.8965 cm 0 0 m 90.959 0 l S Q q 1 0 0 1 42.7697 623.6773 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 133.4783 634.8965 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 133.4783 623.6773 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 178.8327 634.8965 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 178.8327 623.6773 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 224.187 634.8965 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 224.187 623.6773 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 269.5413 634.8965 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 269.5413 623.6773 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 314.8957 634.8965 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 314.8957 623.6773 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 360.25 634.8965 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 360.25 623.6773 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 405.6043 634.8965 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 405.6043 623.6773 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 450.9586 634.8965 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 450.9586 623.6773 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 496.313 623.6773 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 42.5197 623.4273 cm 0 0 m 90.959 0 l S Q q 1 0 0 1 42.7697 612.2081 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 133.4783 623.4273 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 133.4783 612.2081 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 178.8327 623.4273 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 178.8327 612.2081 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 224.187 623.4273 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 224.187 612.2081 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 269.5413 623.4273 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 269.5413 612.2081 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 314.8957 623.4273 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 314.8957 612.2081 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 360.25 623.4273 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 360.25 612.2081 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 405.6043 623.4273 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 405.6043 612.2081 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 450.9586 623.4273 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 450.9586 612.2081 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 496.313 612.2081 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 42.5197 611.9581 cm 0 0 m 90.959 0 l S Q q 1 0 0 1 42.7697 600.7388 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 133.4783 611.9581 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 133.4783 600.7388 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 178.8327 611.9581 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 178.8327 600.7388 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 224.187 611.9581 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 224.187 600.7388 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 269.5413 611.9581 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 269.5413 600.7388 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 314.8957 611.9581 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 314.8957 600.7388 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 360.25 611.9581 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 360.25 600.7388 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 405.6043 611.9581 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 405.6043 600.7388 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 450.9586 611.9581 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 450.9586 600.7388 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 496.313 600.7388 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 42.5197 600.4888 cm 0 0 m 90.959 0 l S Q q 1 0 0 1 133.4783 600.4888 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 178.8327 600.4888 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 224.187 600.4888 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 269.5413 600.4888 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 314.8957 600.4888 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 360.25 600.4888 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 405.6043 600.4888 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 450.9586 600.4888 cm 0 0 m 45.604 0 l S Q BT /GS1 gs /T1_3 1 Tf 8 0 0 8 46.8205 695.0772 Tm (\021\f\t\b\t\201\r\217\220\004\235 \220\004\003\r\n\002\006\t\235)Tj 26.509 1.434 Td (\200\002\217\003\003\r\006\004\212\r\003\t\201\r\217\220\004\235 \220\004\ \003\r\n\002\006\t\235)Tj -6.443 -1.434 Td (\200\004\003\002\214\002\006\226\002\f\002\n\t\201\r\217\220\004\235)Tj 24.779 0 Td (\021\f\t\b\t\201\r\217\220\004\235)Tj -32.764 -1.434 Td (ypT0/is)Tj 6.257 0 Td (ypT1)Tj 5.669 0 Td (ypT2)Tj 5.669 0 Td (ypT3)Tj 5.669 0 Td (ypT4)Tj 5.609 0 Td (y\217N0)Tj 5.669 0 Td (y\217N1)Tj 5.669 0 Td (y\217N2)Tj /T1_1 1 Tf -52.446 -1.433 Td (cT2 \()Tj /T1_4 1 Tf (n)Tj /T1_1 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (8\))Tj 13.569 0 Td (5)Tj 5.669 0 Td (3)Tj 0 1 1 0 k /GS0 gs /T1_3 1 Tf 5.641 -0.001 Td (\231)Tj 0 0 0 1 k /GS1 gs /T1_1 1 Tf 5.669 0.001 Td (\226)Tj 5.669 0 Td (\226)Tj -36.218 -1.434 Td (cT3 \()Tj /T1_4 1 Tf (n)Tj /T1_1 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (10\))Tj 13.569 0 Td (4)Tj 5.669 0 Td (2)Tj 5.669 0 Td (2 )Tj 0 1 1 0 k /GS0 gs /T1_3 1 Tf 5.641 -0.001 Td (2)Tj 0 0 0 1 k /GS1 gs /T1_1 1 Tf 5.669 0.001 Td (\226)Tj -36.218 -1.434 Td (cT4 \()Tj /T1_4 1 Tf (n)Tj /T1_1 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (2\))Tj 13.541 0 Td (\226)Tj 5.697 0 Td (2)Tj 5.641 0 Td (\226)Tj 5.669 0 Td (\226)Tj 0 1 1 0 k /GS0 gs /T1_3 1 Tf 5.669 -0.001 Td (\231)Tj 0 0 0 1 k /GS1 gs /T1_1 1 Tf -36.218 -1.433 Td (cN0 \()Tj /T1_4 1 Tf (n)Tj /T1_1 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (8\))Tj 0 1 1 0 k /GS0 gs /T1_3 1 Tf 41.887 -0.001 Td (8)Tj 0 0 0 1 k /GS1 gs /T1_1 1 Tf 5.669 0.001 Td (\226)Tj 5.669 0 Td (\226)Tj -53.226 -1.434 Td (cN1 \()Tj /T1_4 1 Tf (n)Tj /T1_1 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (10\))Tj 41.915 0 Td (9)Tj 0 1 1 0 k /GS0 gs /T1_3 1 Tf 5.641 -0.001 Td (1)Tj 0 0 0 1 k /GS1 gs /T1_1 1 Tf 5.669 0.001 Td (\226)Tj -53.226 -1.434 Td (cN2 \()Tj /T1_4 1 Tf (n)Tj /T1_1 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (2\))Tj 41.915 0 Td (2)Tj 5.641 0 Td (\226)Tj 0 1 1 0 k /GS0 gs /T1_3 1 Tf 5.669 -0.001 Td (\231)Tj 0 0 0 1 k /GS1 gs -53.226 -1.434 Td (\034\003\002\n\002)Tj /T1_1 1 Tf 13.569 0.001 Td (9)Tj 5.669 0 Td (5)Tj 5.669 0 Td (3)Tj 5.669 0 Td (3)Tj 5.641 0 Td (\226)Tj 5.447 0 Td (19)Tj 5.919 0 Td (1)Tj 5.669 0 Td (0)Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\033\030\031\030\213\b)-20.9(\035\231\213\233\t \021\032)50(\b)42(\032\231\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj /T1_5 1 Tf 25 0 0 25 512.8021 56.0378 Tm (85)Tj ET endstream endobj 1720 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 70.936 724.8299 Tm (\023\023\034\226\034\022\031\034)Tj 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0 Tc -0.055 Tw 10 0 0 10 70.8661 700.4739 Tm (\217\026\022 \023\030\016\n\024\005 \022\017\001\022\017 \(\217\215\025\)\ \026\027\017\n\026\036\021 6 \n\036\f\021\024 \r)Tj /Span<>> BDC ( )Tj EMC (\f\021\030\031\022\021\031\030\036 )Tj 0.021 Tw 0 -1.218 TD (\035\024\022\026\004\036\f\021\r\036\027\027\t\b \027\024\r\024\024\002\ \030\026\024\r\026\027\017\005 \r)Tj /Span<>> BDC ( )Tj EMC (\217\024\f\f\017\017, \f\024\f\021\026\r)Tj 0 Tw (-)Tj 0.232 Tw T* (\035\016\016 5,8% \f\030\036\007\017 \035\024\022\026\004\036\f\021\r\036\ \027\027\t\b \027\024\r\024\024\002\030\026\024\r\026\027\017\005 )Tj 0.123 Tw T* (\031)Tj /Span<>> BDC ( )Tj EMC (\n\031\032\004\017\027 \017)Tj /Span<>> BDC ( )Tj EMC (4,6%)Tj /Span<>> BDC ( )Tj EMC (\227 \031)Tj /Span<>> BDC ( )Tj EMC (\032\036\027\013\017\027. \217\026\f\023\030\024\f\021\030\026\027\036\027\ \027\024\f\021\034 )Tj 0.003 Tw T* (\220\021\024\005 \235\024\030\n\t \026\002\024\035\036\r\026\027\017\016\ \r)Tj /Span<>> BDC ( )Tj EMC (\217\024\f\f\017\017 \r)Tj /Span<>> BDC ( )Tj EMC (2022 \020\024\007\031 \f\024\f\021\026)Tj 0 Tw (-)Tj -0.066 Tw 0 -1.218 TD (\r\017\035\026 124,6 \004\036\035\024\r\036\022 \027\026)Tj /Span<>> BDC ( )Tj EMC (100000 \027\026\f\036\035\036\027\017\016 [1]. \215\030\017)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\n )Tj -0.032 Tw 0 -1.218 TD (\002\024\035\034\001\026\016 \004\026\f\021\034 \002\024\035\034\027\t\b\ \f)Tj /Span<>> BDC ( )Tj EMC (\r\023\036\030\r\t\036 \r\t\016\r\035\036\027\027\024\005 \024\023\031\b\ \024)Tj 0 Tw (-)Tj T* (\035\034\033 \017\n\036\036\021 III-IV \f\021\026\007\017\033 \026\002\024\ \035\036\r\026\027\017\016 \(51,6%\).)Tj 0.138 Tw T* (\221\021\026\027\007\026\030\021\024\n \035\036\004\036\027\017\016 \002\ \024\035\034\027\t\b \n\036\f\021\027\024\030\026\f\023\030\024\f\021\030\ \026\027\036\027)Tj 0 Tw (-)Tj 0.153 Tw T* [(\027\t\n\017 )0.5(\235\024\030\n\026\n\017 )0.6(\217\215\025 )0.5(\016\r\035\016\036\021\f\016 )0.5(\023\030\017\n\036\027\036\027\017\036 )0.6(\b\017\n\017\024\035\031)]TJ 0 Tw (-)Tj 0.328 Tw 0 -1.218 TD (\004\036\r\024\005 \021\036\030\026\023\017\017 \(\216\214\230\), \035\017\ \002\024 \017\027\021\036\027\f\017\r\027\t\b \030\036\032\017\n\024\r )Tj 0.068 Tw 0 -1.218 TD (\035\031\004\036\r\024\005 \021\036\030\026\023\017\017 \(\214\230\) \f)Tj /Span<>> BDC ( )Tj EMC (\024\021\f\030\024\004\036\027\027\t\n \b\017\030\031\030\020\017\004\036\ \f\022\017\n )Tj -0.025 Tw 0 -1.218 TD [(\r\n\036\001\026\021\036\035\034\f\021\r\024\n )0.5([2]. )0.5(\215\030\017\n\036\030\027\024 )0.5(\031)]TJ /Span<>> BDC ( )Tj EMC [(10\22625% )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 18.427 0 Td [(\027\017\b )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC (\030\036)Tj 0 Tw (-)Tj 0.248 Tw -18.427 -1.218 Td (\031\035\034\021\026\021\036 \035\036\004\036\027\017\016 \024\021\n\036\ \004\026\036\021\f\016 \023\024\035\027\024\036 \017\f\004\036\027\024\r\ \036\027\017\036 )Tj 0.182 Tw 0 -1.218 TD (\024\023\031\b\024\035\017, \024\f\024\002\036\027\027\024 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\017\f\023\024\035\034\024\r\026\027\017\017 \r)Tj /Span<>> BDC ( )Tj EMC (\017\027\021\036\030\r\026\035\036 )Tj 0.137 Tw 0 -1.218 TD (\n\036\032\007\031 \026\r\036\030\001\036\027\017\036\n \024\002\035\031\ \004\036\027\017\016 \017)Tj /Span<>> BDC ( )Tj EMC (\024\023\036\030\026\006\017\036\005 \022\024\027\f\024)Tj 0 Tw (-)Tj -0.001 Tw 0 -1.218 TD (\035\017\007\017\030\031\033\013\036\005 \b\017\n\017\024\021\036\030\026\ \023\017\017 [3\2266]. \221\024\r\030\036\n\036\027\027\t\036 \023\024\007\ )Tj 0 Tw (-)Tj 0.208 Tw 0 -1.218 TD (\b\024\007\t \022)Tj /Span<>> BDC ( )Tj EMC (\r\036\007\036\027\017\033 \023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\023\024\035\027\t\n \022\035\017\027\017\004\036\f\022\017\n )Tj 0.572 Tw T* (\024\021\r\036\021\024\n \(cCR\) \023\030\036\007\023\024\035\026\020\026\ \033\021 \024\030\020\026\027\024\f\024\b\030\026\027\016\033\013\036\036\ )Tj -0.026 Tw 0 -1.218 TD (\035\036\004\036\027\017\036, \023\024\007 \022\024\021\024\030\t\n \023\ \024\007\030\026\031\n\036\r\026\036\021\f\016 \035\017\002\024 \007\017\ \027\026\n\017)Tj 0 Tw (-)Tj 0.105 Tw 0 -1.218 TD [(\004\036\f\022\024\036 )0.5(\027\026\002\035\033\007\036\027\017\036 )0.6(\026)]TJ /Span<>> BDC ( )Tj EMC 9.792 0 Td [(\023\026\006\017\036\027\021\024\n, )0.6(\035\017\002\024 )0.5(\r\t\023\024\035\027\036\027\017\036 )]TJ 0.01 Tw -9.792 -1.218 Td (\035\024\022\026\035\034\027\024\020\024 \017\f\f\036\004\036\027\017\016\ \024\027\t \030\031\002\006\026 \027\026)Tj /Span<>> BDC ( )Tj EMC (\n\036\f\021\036 \030\026\027\036\036 \f\031)Tj 0 Tw (-)Tj 0 -1.218 TD (\013\036\f\021\r\024\r\026\r\001\036\005 \024\023\031\b\024\035\017 [7\226\ 9].)Tj 0.356 Tw T* (\221\030\036\007\017 \n\036\021\024\007\024\r \021\030\026\027\f\026\027\ \026\035\034\027\024\020\024 \035\024\022\026\035\034\027\024\020\024 \031\ \007\026\035\036)Tj 0 Tw (-)Tj 0.285 Tw T* (\027\017\016 \024\023\031\b\024\035\017 \023\030\016\n\024\005 \022\017\001\ \022\017 \027\026\017\002\024\035\036\036 \030\026\f\023\030\024\f\021\030\ \026)Tj 0 Tw (-)Tj 0.186 Tw T* (\027\036\027\027\t\n\017 \016\r\035\016\033\021\f\016 \021\030\026\027\f\ \026\027\026\035\034\027\024\036 \220\027\007\024\f\022\024\023\017\004\036\ \f\022\024\036 )Tj 0.463 Tw T* (\n\017\022\030\024\b\017\030\031\030\020\017\004\036\f\022\024\036 \r\n\036\ \001\026\021\036\035\034\f\021\r\024 \(\230\224\204\), \021\030\026\027\f\ )Tj 0 Tw (-)Tj 0.089 Tw T* [(\026\027\026\035\034\027\t\036 )0.6(\220\027\007\024\f\022\024\023\017\004\036\f\022\017\036 )0.6(\024\023\036\030\026\006\017\017 )0.5(\(\230\224\210\) )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 19.465 0 Td (\021\030\026\027\f)Tj 0 Tw (-)Tj 0.021 Tw -19.465 -1.218 Td [(\026\027\026\035\034\027\026\016 \n\026\035\024\017\027\r\026\017\r\027\ \026\016 \b\017\030\031\030\020\017\016 \(T)35(AMIS\). \212\026\027\027\t\036 )]TJ 0.12 Tw T* [(\b\017\030\031\030\020\017\004\036\f\022\017\036 )0.6(\r\n\036\001\026\021\036\035\034\f\021\r\026 )0.5(\023\024\r\024\035\016\033\021 )0.6(\r\t\023\024\035\027\016\021\034 )]TJ 0.312 Tw T* (\023\024\035\027\024\f\035\024\005\027\024\036 \017\f\f\036\004\036\027\017\ \036 \024\023\031\b\024\035\017 \007\024)Tj /Span<>> BDC ( )Tj EMC (\024\022\030\031\032\026\033\013\036\005 )Tj 0.068 Tw T* (\n\036\024\030\036\022\021\026\035\034\027\024\005 \022\035\036\021\004\ \026\021\022\017 \f)Tj /Span<>> BDC ( )Tj EMC (\023\024\f\035\036\007\031\033\013\017\n \031\001\017\r\026\027\017)Tj 0 Tw (-)Tj 0.147 Tw T* (\036\n \007\036\235\036\022\021\026. \215\030\017)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\n \027\026\017\002\024\035\036\036 \f\021\026\027\007\026\030\ \021\017\024\r\026\027\027\024\005 )Tj 0.268 Tw T* (\b\017\030\031\030\020\017\004\036\f\022\024\005 \021\036\b\027\017\022\024\ \005 \027\026)Tj /Span<>> BDC ( )Tj EMC (\f\036\020\024\007\027\016\001\027\017\005 \007\036\027\034 \016\r)Tj 0 Tw (-)Tj 0.187 Tw T* (\035\016\036\021\f\016 \230\224\204. \230\224\204)Tj /Span<>> BDC ( )Tj EMC (\227 \027\026\017\002\024\035\036\036 \220\235\235\036\022\021\017\r\027\ \t\005 \b\017\030\031\030)Tj 0 Tw (-)Tj 0.375 Tw T* (\020\017\004\036\f\022\017\005 \n\036\021\024\007 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\007\024\002\030\024\022\026\004\036\f\021\r\036\027\027\t\b \024\023\031\ \b\024\035\016\b )Tj 0.109 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC [(\030\026\027\027\036\n \(cT)35(is-T1s)26(m1/s)26(m2\) \217\215\025. \200\n\036\f\021\036 \f)]TJ /Span<>> BDC ( )Tj EMC (\021\036\n, \031)Tj /Span<>> BDC ( )Tj EMC (\023\026)Tj 0 Tw (-)Tj 0.087 Tw T* (\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC [(\n\036\f\021\027\024\030\026\f\023\030\024\f\021\030\026\027\036\027\027\ \t\n\017 )0.5(\024\023\031\b\024\035\016\n\017 )0.5(\023\024)]TJ 0 Tw (-)Tj 0.101 Tw T* (\f\035\036 \214\230/\216\214\230 \r\024\023\030\024\f \024)Tj /Span<>> BDC ( )Tj EMC (\006\036\035\036\f\024\024\002\030\026\027\024\f\021\017 \023\030\017\n\ \036\027\036\027\017\016 )Tj -0.033 Tw T* (\230\224\204 \024\f\021\026\036\021\f\016 \007\017\f\022\031\021\026\002\ \036\035\034\027\t\n. \210\f\024\002\036\027\027\024 \220\021\024 \022\026\ \f\026\036\021\f\016 )Tj 0.108 Tw T* (\f\035\031\004\026\036\r cCR. \215\030\017)Tj /Span<>> BDC ( )Tj EMC (\023\024\004\021\017 \023\024\035\027\024\n \022\035\017\027\017\004\036\ \f\022\024\n \024\021\r\036\021\036 )Tj 0.138 Tw 0 -1.218 TD (\(nCR\) \220\021\026 \024\023\006\017\016 \n\024\032\036\021 \024\022\026\ \026\021\034\f\016 \027\036 \021\024\035\034\022\024 \r\026\032\027\024\ \005 )Tj 0.084 Tw 0 -1.218 TD (\007\017\026\020\027\024\f\021\017\004\036\f\022\024\005 \023\030\024\006\ \036\007\031\030\024\005, \027\024 \017)Tj /Span<>> BDC ( )Tj EMC (\030\026\007\017\022\026\035\034\027\t\n \b\017)Tj 0 Tw (-)Tj 0.001 Tw 0 -1.218 TD (\030\031\030\020\017\004\036\f\022\017\n \r\n\036\001\026\021\036\035\034\ \f\021\r\024\n [10], \023\030\017\r\024\007\016\013\017\n \022)Tj /Span<>> BDC ( )Tj EMC (\017)Tj 0 Tw (-)Tj 0.014 Tw T* (\035\036\004\036\027\017\033 \023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\f\024\b\030\026\027\036\027\017\036\n \036\f\021\036\f\021\r\036\027\027\ \024\020\024 \026)Tj 0 Tw (-)Tj T* (\023\017\030\026\021\036\035\034\027\024\020\024 \026\023\023\026\030\026\ \021\026 \023\030\016\n\024\005 \022\017\001\022\017.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 70.936 115.9298 Tm (\017\034\r\241)Tj 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0 Tc 0.121 Tw 10 0 0 10 70.8661 91.5738 Tm (\037\036\035\034 \027\026\f\021\024\016\013\036\020\024 \017\f\f\035\036\ \007\024\r\026\027\017\016)Tj /Span<>> BDC ( )Tj EMC (\227 \026\027\026\035\017 \030\036\031\035\034\021\026)Tj 0 Tw (-)Tj 0.059 Tw T* (\021\024\r \035\036\004\036\027\017\016 \002\024\035\034\027\t\b \217\215\ \025 \f)Tj /Span<>> BDC ( )Tj EMC (\b\024\030\024\001\017\n \024\021\r\036\021\024\n \027\026)Tj /Span<>> BDC ( )Tj EMC (\214\230/)Tj -0.039 Tw 23.244 64.543 Td (\216\214\230, \022\024\021\024\030\t\n \002\t\035\017 \r\t\023\024\035\027\ \036\027\t \b\017\030\031\030\020\017\004\036\f\022\017\036 \r\n\036\001\ \026)Tj 0 Tw (-)Tj T* (\021\036\035\034\f\021\r\026 \r)Tj /Span<>> BDC ( )Tj EMC (\024\002\255\036\n\036 \230\224\204.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 0.01 Tc 0.018 Tw 14 0 0 14 303.3769 676.1179 Tm [(\f\026\017\031\034\022\024\232)5( \031)5(\016)-18.3(\240\034)-31(\024)35(\037\226\232)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0 Tc -0.019 Tw 10 0 0 10 303.3071 651.7618 Tm (\200 \204\217\203\037 \017\n. \202.\205.)Tj /Span<>> BDC ( )Tj EMC (\037\t\002\026 \r)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\017\024\007 \f)Tj /Span<>> BDC ( )Tj EMC (2019 \023\024)Tj /Span<>> BDC ( )Tj EMC (2023 \020\020. \b\017)Tj 0 Tw (-)Tj 0.076 Tw T* (\030\031\030\020\017\004\036\f\022\017\036 \r\n\036\001\026\021\036\035\034\ \f\021\r\026 \r)Tj /Span<>> BDC ( )Tj EMC (\024\002\255\036\n\036 \230\224\204 \023\024\f\035\036 \214\230/)Tj 0.011 Tw T* (\216\214\230 \002\t\035\017 \r\t\023\024\035\027\036\027\t 20 \002\024\035\ \034\027\t\n \(15 \n\031\032\004\017\027/5)Tj /Span<>> BDC ( )Tj EMC (\032\036\027)Tj 0 Tw (-)Tj 0.201 Tw 0 -1.218 TD (\013\017\027\) \f)Tj /Span<>> BDC ( )Tj EMC (\026\007\036\027\024\022\026\030\006\017\027\024\n\024\005 \023\030\016\n\ \024\005 \022\017\001\022\017 \f)Tj /Span<>> BDC ( )Tj EMC (cCR \017\035\017 )Tj -0.044 Tw 0 -1.218 TD (nCR. \204\036\007\017\026\027\026 \r\024\030\026\f\021\026 \002\024\035\ \034\027\t\b \f\024\f\021\026\r\017\035\026 61 \(26\22677\) )Tj -0.013 Tw 0 -1.218 TD (\020\024\007. \211)Tj /Span<>> BDC ( )Tj EMC (4 \023\026\006\017\036\027\021\024\r \002\t\035\017 \022\035\017\027\017\ \004\036\f\022\017 \031\f\021\026\027\024\r\035\036\027\t \027\024)Tj 0 Tw (-)Tj -0.021 Tw T* (\r\024\024\002\030\026\024\r\026\027\017\016 I \f\021\026\007\017\017, \ \031)Tj /Span<>> BDC ( )Tj EMC (4)Tj /Span<>> BDC ( )Tj EMC (\227 II \017)Tj /Span<>> BDC ( )Tj EMC (\031 12)Tj /Span<>> BDC ( )Tj EMC (\227 III \f\021\026\007\017\017.)Tj 0.395 Tw T* (\211 \r\f\036\b \023\026\006\017\036\027\021\024\r \024\023\031\b\024\035\ \017 \030\026\f\023\024\035\026\020\026\035\017\f\034 \r)Tj /Span<>> BDC ( )Tj EMC (\007\017\f)Tj 0 Tw (-)Tj 0.291 Tw T* (\021\026\035\034\027\t\b \024\021\007\036\035\026\b \023\030\016\n\024\005\ \022\017\001\022\017, \004\021\024 \023\030\036\007\023\024\035\026\020\ \026\035\024 )Tj 0.336 Tw 0 -1.218 TD [(\r\t\023\024\035\027\036\027\017\036 )0.6(\035\017\002\024 )0.5(\002\030\033\001\027\024-\023\030\024\n\036\032\027\024\f\021\027\024\005\ )0.6(\220\022\f\021\017\030)]TJ 0 Tw (-)Tj 0.179 Tw 0 -1.218 TD (\023\026\006\017\017, \035\017\002\024 \024\004\036\027\034 \027\017\022\ \024\005 \023\036\030\036\007\027\036\005 \030\036\036\022\006\017\017 \ \023\030\016)Tj 0 Tw (-)Tj 0.189 Tw 0 -1.218 TD (\n\024\005 \022\017\001\022\017. \211)Tj /Span<>> BDC ( )Tj EMC (17)Tj /Span<>> BDC ( )Tj EMC (\(85,0%\) \023\026\006\017\036\027\021\024\r \002\t\035 \023\030\017\n\036\ \027\036\027 )Tj 0.138 Tw T* (\023\030\024\035\024\027\020\017\030\024\r\026\027\027\t\005 \030\036\032\ \017\n \214\230 \r)Tj /Span<>> BDC ( )Tj EMC (\007\024\036 50 \206\030 \(2)Tj /Span<>> BDC ( )Tj EMC (\327)Tj /Span<>> BDC ( )Tj EMC (25\) )Tj 0.291 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\f\024\004\036\021\026\027\017\017 \f)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\024\030\026\035\034\027\t\n \023\030\017\036\n\024\n \022\026\ \023\036\006\017\021\026\002\017)Tj 0 Tw (-)Tj 0.088 Tw T* (\027\026 \r)Tj /Span<>> BDC ( )Tj EMC (\007\024\036 825)Tj /Span<>> BDC ( )Tj EMC (\n\020/\n)Tj 0 Tw 5.83 0 0 5.83 384.0574 484.5998 Tm (2)Tj 0.088 Tw 10 0 0 10 386.9724 481.2698 Tm ( \007\r\026\032\007\t \r)Tj /Span<>> BDC ( )Tj EMC (\007\036\027\034. \200)Tj /Span<>> BDC ( )Tj EMC (\023\024\f\035\036\007\031\033\013\036\n )Tj 0.158 Tw -8.367 -1.218 Td (\031)Tj /Span<>> BDC ( )Tj EMC (14 \002\024\035\034\027\t\b \023\030\024\r\024\007\017\035\017 \022\024\027\ \f\024\035\017\007\017\030\031\033\013\031\033 \b\017\n\017\024)Tj 0 Tw (-)Tj 0.237 Tw T* (\021\036\030\026\023\017\033 \r)Tj /Span<>> BDC ( )Tj EMC [(\030\036\032\017\n\036 FOLFO)17.1(X6 \(\r 1 \f\035\031\004\026\036 \r)]TJ /Span<>> BDC ( )Tj EMC (\022\024\035\017\004\036)Tj 0 Tw (-)Tj 0.034 Tw T* (\f\021\r\036 2 \006\017\022\035\024\r, \r)Tj /Span<>> BDC ( )Tj EMC (12)Tj /Span<>> BDC ( )Tj EMC (\227 4 \017)Tj /Span<>> BDC ( )Tj EMC (\r \036\013\036 \024\007\027\024\n)Tj /Span<>> BDC ( )Tj EMC (\227 6 \006\017\022\035\024\r\). )Tj 0.071 Tw T* (\215\030\024\035\024\027\020\017\030\024\r\026\027\027\t\005 \030\036\032\ \017\n \214\230 \r)Tj /Span<>> BDC ( )Tj EMC (\007\024\036 54 \206\030 \r)Tj /Span<>> BDC ( )Tj EMC (\f\024\004\036\021\026)Tj 0 Tw (-)Tj 0.054 Tw T* [(\027\017\017 )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC [(\023\036\030\024\030\026\035\034\027\t\n )0.5(\023\030\017\036\n\024\n \022\026\023\036\006\017\021\026\002\017\027\026\ )0.5(\002\t\035 )0.5(\023\030\017)]TJ 0 Tw (-)Tj -0.006 Tw T* (\n\036\027\036\027 \r)Tj /Span<>> BDC ( )Tj EMC (2 \f\035\031\004\026\016\b \(10,0%\). \211)Tj /Span<>> BDC ( )Tj EMC (1 \(5,0%\) \023\026\006\017\036\027\021\022\017 \023\030\017)Tj 0 Tw (-)Tj 0.125 Tw T* (\n\036\027\017\035\017 \017\027\021\036\027\f\017\r\027\024\036 \024\002\ \035\031\004\036\027\017\036 \r)Tj /Span<>> BDC ( )Tj EMC (\007\024\036 25\206\030 \(5)Tj /Span<>> BDC ( )Tj EMC (\327)Tj /Span<>> BDC ( )Tj EMC (5\) )Tj 0.145 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (4)Tj /Span<>> BDC ( )Tj EMC [(\006\017\022\035\026\n\017 )0.5(\022\024\027\f\024\035\017\007\017\030\031\033\013\036\005 )0.5(\b\017\n\017\024\021\036\030\026\023\017\017 )0.6(\r)]TJ /Span<>> BDC ( )Tj EMC 20.789 0 Td (\030\036)Tj 0 Tw (-)Tj -20.789 -1.218 Td [(\032\017\n\036 FOLFO)17.1(X6.)]TJ 0.237 Tw T* (\217\026\f\f\021\024\016\027\017\036 \024\021 \026\027\026\035\034\027\024\ \020\024 \022\030\026\016 \007\024)Tj /Span<>> BDC ( )Tj EMC (\027\017\032\027\036\020\024 \023\024\035\033\f\026 )Tj 0.161 Tw T* [(\024\023\031\b\024\035\017 )0.6(\022\024\035\036\002\026\035\024\f\034 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 9.761 0 Td [(\007\017\026\023\026\024\027\036 )0.6(\024\021 )0.5(2 )0.5(\007\024)]TJ /Span<>> BDC ( )Tj EMC 8.294 0 Td (7)Tj /Span<>> BDC ( )Tj EMC 0.893 0 Td [(\f\n )0.5(\(\n\036)]TJ 0 Tw (-)Tj 0.051 Tw -18.949 -1.218 Td (\007\017\026\027\026)Tj /Span<>> BDC ( )Tj EMC 2.733 0 Td [(\227 )0.5(4 )0.5(\f\n\). )0.5(\217\026\n\036\030 )0.6(\024\023\031\b\024\035\017 )0.5(\023\024\f\035\036 )0.5(\023\030\024\r\036\007\036\027\027\024\020\024 )]TJ -0.025 Tw -2.733 -1.218 Td (\035\036\004\036\027\017\016 \r\026\030\034\017\030\024\r\026\035 \r)Tj /Span<>> BDC ( )Tj EMC (\023\030\036\007\036\035\026\b \024\021 1,4 \007\024)Tj /Span<>> BDC ( )Tj EMC (6,0 \f\n \r)Tj /Span<>> BDC ( )Tj EMC (\007\017\026)Tj 0 Tw (-)Tj 0.042 Tw T* (\n\036\021\030\036 \023\024)Tj /Span<>> BDC ( )Tj EMC (\007\026\027\027\t\n \204\217\230-\017\f\f\035\036\007\024\r\026\027\017\ \016 \(\n\036\007\017\026\027\026)Tj /Span<>> BDC ( )Tj EMC (\227 \f\024)Tj 0 Tw (-)Tj T* (\f\021\026\r\017\035\026 2,5 \f\n\).)Tj 0.112 Tw T* (\204\036\007\017\026\027\026 \017\027\021\036\030\r\026\035\026 \n\036\032\ \007\031 \214\230 \017)Tj /Span<>> BDC ( )Tj EMC (\024\023\036\030\026\006\017\036\005 \f\024\f\021\026\r\017)Tj 0 Tw (-)Tj 0.186 Tw T* (\035\026 22 \(12\22678\) \027\036\007\036\035\017. \211)Tj /Span<>> BDC ( )Tj EMC (5)Tj /Span<>> BDC ( )Tj EMC (\(25,0%\) \002\024\035\034\027\t\b, \r\022\035\033)Tj 0 Tw (-)Tj 0.289 Tw T* (\004\036\027\027\t\b \r)Tj /Span<>> BDC ( )Tj EMC (\017\f\f\035\036\007\024\r\026\027\017\036, \002\t\035 \026\030\036\020\ \017\f\021\030\017\030\024\r\026\027 cCR )Tj 0.092 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC [(\023\030\024\r\036\007\036\027\027\024\036 \027\036\024\026\007\255\033\r\ \026\027\021\027\024\036 \035\036\004\036\027\017\036. )0.5(\025)]TJ /Span<>> BDC ( )Tj EMC (cCR \024\021)Tj 0 Tw (-)Tj 0.022 Tw T* (\027\024\f\017\035\017 \f\035\031\004\026\017, \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\022\024\021\024\030\t\b \023\024)Tj /Span<>> BDC ( )Tj EMC (\f\024\r\024\022\031\023\027\024\f\021\017 \007\026\027\027\t\b )Tj 0.736 Tw T* (\023\026\035\034\006\036\r\024\020\024 \017\f\f\035\036\007\024\r\026\027\ \017\016, \n\026\020\027\017\021\027\024-\030\036\024\027\026\027\f\027\ \024\005 )Tj 0.284 Tw T* (\021\024\n\024\020\030\026\235\017\017 \024\030\020\026\027\024\r \n\026\ \035\024\020\024 \021\026\026 \(\204\217\230)Tj /Span<>> BDC ( )Tj EMC (\227 TRG1,2\) )Tj 0.105 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\220\027\007\024\f\022\024\023\017\004\036\f\022\024\005 \022\026\030\021\ \017\027\t \(\023\035\024\f\022\017\005 \002\036\035\t\005 \030\031\002\036\ \006/)Tj 0.366 Tw T* (\021\036\035\036\026\027\020\017\220\022\021\026\017\017\) \027\036 \002\ \t\035\024 \026\030\036\020\017\f\021\030\017\030\024\r\026\027\024 \023\ \030\017)Tj 0 Tw (-)Tj 0.194 Tw T* (\027\026\022\024\r \024\f\021\026\021\024\004\027\024\005 \024\023\031\b\ \024\035\017. \200)Tj /Span<>> BDC ( )Tj EMC (15 \f\035\031\004\026\016\b \230\224\204 \002\t\035 )Tj 0.176 Tw T* (\r\t\023\024\035\027\036\027 \023\026\006\017\036\027\021\026\n \f)Tj /Span<>> BDC ( )Tj EMC (nCR, \023\024\007 \022\024\021\024\030\t\n \023\024\027\017\n\026\035\017\ )Tj 0.118 Tw T* (\023\024\007\024\030\036\027\017\036 \027\026)Tj /Span<>> BDC ( )Tj EMC (\027\026\035\017\004\017\036 \017\035\017 \n\017\027\017\n\026\035\034\027\ \t\036 \023\030\017\027\026\022\017 )Tj 0.235 Tw T* (\024\f\021\026\021\024\004\027\024\005 \024\023\031\b\024\035\017 \(\204\ \217\230)Tj /Span<>> BDC ( )Tj EMC (\227 TRG2-3, \220\027\007\024\f\022\024\023\017\004\036)Tj 0 Tw (-)Tj 0.125 Tw T* (\f\022\024\036 \017\f\f\035\036\007\024\r\026\027\017\036)Tj /Span<>> BDC ( )Tj EMC (\227 \023\024\r\036\030\b\027\024\f\021\027\026\016 \016\r\026, \022\030\ \026\f\027\t\005 )Tj -0.024 Tw T* (\030\031\002\036\006, \023\024\022\030\t\021\t\005 \235\017\002\030\017\027\ \024\n, \n\017\027\017\n\026\035\034\027\026\016 \024\f\021\026\021\024\004\ \027\026\016 )Tj 0.042 Tw T* (\024\023\031\b\024\035\036\r\026\016 \017\035\017 \026\007\036\027\024\n\ \026\021\024\027\026\016 \021\022\026\027\034\). \200\f\036\n \023\026\006\ \017\036\027)Tj 0 Tw (-)Tj 0.004 Tw T* (\021\026\n \f)Tj /Span<>> BDC ( )Tj EMC (nCR \r)Tj /Span<>> BDC ( )Tj EMC (\f\024\024\021\r\036\021\f\021\r\017\017 \f)Tj /Span<>> BDC ( )Tj EMC (\022\035\017\027\017\004\036\f\022\017\n\017 \030\036\022\024\n\036\027\007\ \026)Tj 0 Tw (-)Tj 0.177 Tw T* (\006\017\016\n\017 \204\017\027\007\030\026\r\026 \217\024\f\f\017\017 \ [2] \002\t\035\024 \023\030\036\007\r\026\030\017\021\036\035\034\027\024\ )Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0 Tw 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\033\030\031\030\213\b)-20.9(\035\231\213\233\t \021\032)50(\b)42(\032\231\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj -51.938 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 23, \023\0221)69(, 202)69(4)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 23, \023\0221)69(, 202)69(4)]TJ /T1_3 1 Tf 25 0 0 25 28.2152 56.0378 Tm (84)Tj ET endstream endobj 1719 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\032)30(\002\013\001\006\013\001\013\007\216\001\020\016 \232\001\201\025\024\220\ \n\002\025\207\220\002\215\002\202\220\017\016\006\n\220\016 \r\024\016\ \013\026)11(\016\007\216\006)-10(\026\r\013 )]TJ 0 -1 TD [(\221\002\220\022\002\013\n\016 \221\002\205\024\025\203 \n\220\n\220 \221\ \025\006)-10(\007\016 \007\215\017\016\r\025\203 \220\007\220 )]TJ T* [(\207\220\024\220\025\007\215\017\016\r\025\203 \026)11(\016\002\013\221\220\220\022\236 \001\212\013\001\006\020 \220\022\002\016\ \222)21.1(\215\007\216)21(\026)11(\013\026\020)]TJ 32.955 2 Td [(T)20(r)21(ansanal endoscopic micr)20(osur)31(ger)-31(y af)-31(ter r)21(adiation or ch)11(emor)21(adiation )]TJ 7.251 -1 Td [(th)11(er)21(apy for r)31(ectal cancer\022\236 peculiarities and r)31(esults)]TJ ET 0 0 0 1 K 1 j 1 J [0 2.997]0 d /GS1 gs q 1 0 0 1 46.0167 213.9707 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 43.0197 213.9707 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q [0 2.997]0 d q 1 0 0 1 46.0167 167.1629 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 43.0197 167.1629 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q 0 j 0 J q 1 0 0 1 42.5197 103.4937 cm 0 0 m 453.543 0 l S Q BT /GS0 gs /T1_0 1 Tf 0.023 Tw 18 0 0 18 123.369 723.8861 Tm [(T)20(r)21(ansanal endoscopic micr)20.1(osur)31(ger)-31(y af)-30.9(ter )]TJ -1.062 -1.167 Td [(r)21(adiation or ch)11(emor)21(adiation th)11(er)21(apy for r)31(ectal )]TJ 2.529 -1.167 Td [(cancer\022)-23.2(\236 peculiarities and r)31(esults)]TJ 0 0 0 1 k /GS1 gs 0 Tw 14 0 0 14 42.5197 657.3822 Tm [(Alek)11(sey\022)-23.2(A)-31(.\022)-23.3(Ne)11(v)10(olskikh)]TJ 8.162 0 0 8.162 167.4755 662.0442 Tm (1)Tj 0.023 Tw 14 0 0 14 172.1115 657.3822 Tm [(, Ale)21(x)11(ander\022)-23.2(R.\022)-23.3(Br)20(odskiy)]TJ 0 Tw 8.162 0 0 8.162 304.5755 662.0442 Tm (1)Tj 0.023 Tw 14 0 0 14 309.2115 657.3822 Tm [(, Violet)-19.9(ta\022)-23.3(A)-31(.\022)-23.3(A)20(v)10(deenk)11.1(o)]TJ 0 Tw 8.162 0 0 8.162 437.0557 662.0442 Tm (1)Tj 14 0 0 14 441.6916 657.3822 Tm (, )Tj -28.512 -1.143 Td [(T)40(ar)21(as\022)-23.3(P)94(.\022)-23.2(P)9.9(och)11(ue)10.9(v)]TJ 8.162 0 0 8.162 134.4654 646.0442 Tm (1)Tj 0.023 Tw 14 0 0 14 139.1014 641.3822 Tm [(, Y)40(ulia\022)-23.2(Y)40(u.\022)-23.3(Mihale)11(v)10(a)]TJ 0 Tw 8.162 0 0 8.162 251.5741 646.0442 Tm (1)Tj 0.023 Tw 14 0 0 14 256.2101 641.3822 Tm [(, T)40(atiana\022)-23.3(P)94(.\022)-23.3(Ber)31(e)21(z)10(ov)10(skay)21(a)]TJ 0 Tw 8.162 0 0 8.162 398.7966 646.0442 Tm (1)Tj 14 0 0 14 403.4326 641.3822 Tm (, )Tj -25.779 -1.143 Td [(Ruslan\022)-23.2(F)94(.\022)-23.3(Zibir)20(ov)]TJ 8.162 0 0 8.162 134.2682 630.0442 Tm (1)Tj 0.023 Tw 14 0 0 14 138.9042 625.3822 Tm [(, Sof)-21(ia\022)-23.3(A)-31(.\022)-23.3(My)21(alina)]TJ 0 Tw 8.162 0 0 8.162 242.7664 630.0442 Tm (1)Tj 0.023 Tw 14 0 0 14 247.4024 625.3822 Tm [(, Iv)10(an\022)-23.3(A)-30.9(.\022)-23.3(Or)31(eh)11(ov)]TJ 0 Tw 8.162 0 0 8.162 342.1656 630.0442 Tm (1)Tj 0.023 Tw 14 0 0 14 346.8015 625.3822 Tm [(, Leonid\022)-23.2(O.\022)-23.3(P)10(etr)20(ov)]TJ 0 Tw 8.162 0 0 8.162 448.4105 630.0442 Tm (1)Tj 14 0 0 14 453.0464 625.3822 Tm (, )Tj -29.323 -1.143 Td [(Ser)31(gey\022)-23.3(A)-30.9(.\022)-23.3(Iv)10(anov)]TJ -0.069 Tc 0.069 Tw 8.162 0 0 8.162 139.6447 614.0442 Tm [(1,)-69(3)]TJ 0 Tc 0.023 Tw 14 0 0 14 150.9653 609.3822 Tm [(, Andr)31(ey\022)-23.2(D.\022)-23.3(K)41(aprin)]TJ 0 Tw 8.162 0 0 8.162 256.8722 614.0442 Tm (2,3)Tj 5.83 0 0 5.83 42.5197 595.043 Tm (1)Tj 0.023 Tw 10 0 0 10 45.8311 591.713 Tm [(A)-31(.T)40(s)10(yb Medical Radiological Resear)31(ch Centr)31.1(e\022)-23.3(\236 Br)21(anch of th)11(e National Medical Resear)31(ch Radiological Center )]TJ -0.331 -1.2 Td [(of th)11(e Ministr)-30.9(y of Health of th)11.1(e Russian F)19.9(eder)21.1(ation \(Mar)20(shal Zh)11(uk)11(ov\022)-23.3(st., 1)75(0, K)41(aluga r)31(egion, Obninsk, 2)69(4903)138(1)69(, )]TJ 0 Tw 0 -1.2 TD (Russia\))Tj ( )Tj 5.83 0 0 5.83 42.5197 559.043 Tm (2)Tj 0.023 Tw 10 0 0 10 45.8311 555.713 Tm [(National Medical Resear)31.1(ch Radiological Centr)31(e of th)11.1(e Ministr)-30.9(y of Health of th)11(e Russian F)20(eder)21(ation \(K)40.9(or)20(ole)11(v)10(a\022)-23.2(st., )]TJ -0.331 -1.2 Td [(4, K)41(aluga r)31.1(egion, Obninsk, 2)69(4903)138(1)69(, Russia\))]TJ 0 Tw ( )Tj 5.83 0 0 5.83 42.5197 535.0431 Tm (3)Tj 0.023 Tw 10 0 0 10 45.8311 531.7131 Tm [(P)10(eoples)-41.9(\237 Friendship Univ)12(er)20(sit)-19.9(y of Russia, RUDN Univ)12(er)20(sit)-19.9(y \(Miklukh)11(o-Maklay)21(a\022)-23.3(st., 6, Moscow)22(, 1)212(1)137.9(7)127.1(1)138(9)34(8, Russia\))]TJ /T1_1 1 Tf 0.068 Tw 9 0 0 9 90.7087 513.2092 Tm [(INTR)19(ODUCTION: )0.5(the stand)26(ard treatment for patients with )0.5(locally adv)16(anced rectal cancer is the use of chemoradio)]TJ 0 Tw (-)Tj 0.106 Tw 0 -1.111 TD [(therap)12(y \(CRT\) or intensiv)13(e radiation therap)12(y \(RT\) regimens with delayed surg)12(er)-43(y)32.1(. Moreov)13(er)61(, in 10\22625% of cases, )]TJ -0.008 Tw T* [(patients e)-15(xper)-36.9(ience com)16(plete disappearance of the tumor dur)-36.9(ing treatment. Cur)-16(rent app)46(roaches to the manag)11.9(ement )]TJ 0.038 Tw T* [(of cases with a good response in)11(v)13(olv)13(e org)12(an-spar)-37(ing treatment in patients with a com)16(plete clinical response \(cCR\), )]TJ 0.04 Tw T* [(which means dynamic obser)-42(v)16(ation of the patient, or local e)-15(xcision of the scar at the site of a p)46(re-e)-15(xisting tumor in )]TJ 0.023 Tw 0 -1.111 TD [(cases of a near com)16.1(plete clinical response \(nCR\).)]TJ 0.013 Tw 0 -1.111 TD (AIM: to analyze the results of treatment of patients with rectal cancer \ who had a good response to RT/CRT and who )Tj 0.023 Tw T* [(under)-32(w)12(ent transanal endoscopic microsurg)12.1(er)-43(y \(TEM\).)]TJ -0.018 Tc 0.003 Tw T* [(P)45(A)45(TIENT)-10(S A)53(ND METHODS: from 2019 to 2023, 20 patients with rectal adenocarcinoma un\ der)-32(w)12(ent TEM af)-46(ter RT/CRT)62.9(. In all)-18( )]TJ -0.023 Tw T* [(patients, the tumors w)12(ere located in the distal rectum, which req)14(uired either abdominoper)-36.9(ineal resection or ultra low ante)]TJ 0 Tc 0 Tw (-)Tj -0.018 Tc T* [(r)-37(ior rectal resection. The median inter)-42(v)16(al betw)12(een RT and surg)12(er)-43(y w)13(as 22 \(12\22678\) w)12(eek)-23(s. In 5 \(25.0%\) patients included)-18( )]TJ 0.023 Tw T* [(in the study)42(, a cCR w)13(as registered for neoadjuv)16(ant treatment. In 15 cases, TEM w)13(as per)-34(for)-14(med in patients with nCR.)]TJ 0 Tc 0.17 Tw T* [(RESUL)30(T)-10(S: operation time w)13(as 117 minutes, the blood loss w)13(as 40 ml. A com)16(plicated postoperativ)13(e per)-36.9(iod w)13(as )]TJ 0.147 Tw T* [(obser)-41.9(v)12.9(ed in 4)]TJ /Span<>> BDC ( )Tj EMC [(\(20.0%\) patients, among whom the most ser)-37(ious com)16(plication w)13(as suture failure of the sutured )]TJ -0.003 Tw 0 -1.111 TD (intestinal defect)Tj /Span<>> BDC ( )Tj EMC (\227 in 3)Tj /Span<>> BDC ( )Tj EMC [(\(15.0%\) patients. U)22(nfav)13(orable p)46(rognosis factors w)12(ere identif)-42.9(ied in 7)]TJ /Span<>> BDC ( )Tj EMC (\(35%\) patients, while )Tj 0.074 Tw 0 -1.111 TD [(f)-43(inal TEM w)13(as per)-34(for)-13.9(med in only 2)]TJ /Span<>> BDC ( )Tj EMC [(\(28.6%\) of them. In o)13(ther clinical situations, activ)12.9(e follow-up of patients w)13(as )]TJ 0.006 Tw T* [(per)-34(for)-13.9(med)]TJ /Span<>> BDC ( )Tj EMC [(\227 local tumor recur)-15.9(rence w)13(as no)13(t detected in an)11(y case. With a median follow-up of 31.5 \(3-54\) months, )]TJ -0.024 Tw T* [(signs of distant metastases w)12(ere recorded )0.5(in 2)]TJ /Span<>> BDC ( )Tj EMC [(\(10.0%\) cases. Local relapse at 12.3 months w)13(as detected in one case )]TJ -0.015 Tw T* [(\(5.0%\). The cumulativ)13.1(e three-year local recur)-15.9(rence rate w)13(as 6.2)]TJ /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC [(6.1%. Ov)13(erall and disease-free three-year sur)-42(viv)16(al )]TJ 0.023 Tw T* [(rates w)11.9(ere 83.3)]TJ /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (10.8% and 80.4)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC [(10.4%, respectiv)13.1(ely)42(, and stoma-free sur)-42(viv)16(al w)13(as 92.9)]TJ /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (6.9%.)Tj 0.081 Tw T* [(C)21(ON)22(CLUSION: despite the fact that TEM in patients with rectal cancer af)-46(ter RT is an ef)-40(fectiv)12.9(e and safe method of )]TJ 0.041 Tw T* [(treatment, its use in patients with cCR to conf)-43(ir)-14(m a com)16(plete response is inapp)46(rop)46(r)-37(iate and car)-16(r)-37(ies an unnecessar)-43(y )]TJ -0.02 Tw T* [(r)-37(isk of postoperativ)13(e com)16(plications and possible functional dysfunction. The main indication for \ the use of TEM af)-46(ter )]TJ 0.034 Tw 0 -1.111 TD [(RT/CRT is nCR, when local e)-15(xcision of the scar at the site of a p)46(re-e)-15(xisting tumor allows no)13(t only to deter)-14(mine their )]TJ 0.059 Tw 0 -1.111 TD [(pathological nature and treatment app)46(roach, but also for most patients it is a radical surgical inter)-41.9(v)12.9(ention with a )]TJ 0.023 Tw T* [(relativ)13.1(ely low r)-37(isk of local relapse.)]TJ /T1_2 1 Tf 0.01 Tc -0.01 Tw 8 0 0 8 42.5597 247.9399 Tm [(KEYW)22(ORDS:)]TJ /T1_1 1 Tf 0 Tc 0.028 Tw 4.948 0 Td [( rectal cancer)61(, transanal endoscopic microsurg)12.1(er)-43(y)42(, chemoradio)13.1(therap)12.1(y)42(, radiation therap)12(y)42(, com)16.1(plete clinical response, nearly com)16.1(plete )]TJ 0.023 Tw -4.953 -1.2 Td (clinical response)Tj /T1_2 1 Tf 0.01 Tc 0.018 Tw 0.005 -1.909 Td [(C)19(ONFL)-33(ICT)5( OF)5( INTE)25(REST)62(:)]TJ /T1_1 1 Tf 0 Tc 0.023 Tw 9.871 0 Td [( The authors declare that there is no conf)-22(lict of interest)]TJ /T1_2 1 Tf 0.032 Tc -0.043 Tw -9.871 -2.617 Td [(F)2.8(O)-5(R)8.3( C)-17.8(I)-16(T)45(A)37.1(T)-24.8(I)-1.7(ON:)]TJ /T1_3 1 Tf 0.019 Tc -0.035 Tw 6.341 0 Td [( N)-14(e)-15.2(v)-14.8(o)-15(l)-52.5(s)-10.5(k)-40.5(i)-6(k)-16.2(h)]TJ /Span<>> BDC ( )Tj EMC [(A)-22.3(.)-23.3(A)-22.4(.)-22.9(, B)-5.4(r)-15.2(o)-19.8(d)-24(s)-10.5(k)-40.5(i)-16.6(y)]TJ /Span<>> BDC ( )Tj EMC [(A)-22.4(.R)-20.7(.)-22.9(, A)8.2(v)-16.2(d)-14.7(e)-24.6(e)-10.8(n)-8.2(k)-3.1(o)]TJ /Span<>> BDC ( )Tj EMC [(V)40.3(.)-23.3(A)-22.4(.)-22.9(, Po)-16.1(c)-9.6(h)-6.4(u)-11.9(e)-15.2(v)]TJ /Span<>> BDC ( )Tj EMC [(T)53.1(.)1.5(P)108.4(.)-22.9(, M)-9.2(i)-3.6(h)-7.7(a)-10.8(l)-23(e)-15.2(v)-27.8(a)]TJ /Span<>> BDC ( )Tj EMC [(Y)51.9(.)52.2(Y)52(.)-22.9(, B)-18.4(e)-11.5(r)-18.5(e)-23.2(z)-10.6(o)-9.6(v)-28.3(s)-10.5(k)-23.6(a)-14.3(y)-23.6(a)]TJ /Span<>> BDC ( )Tj EMC [(T)53.1(.)1.6(P)108.3(.)-22.9(, Z)-12.9(i)-5.3(b)-18.9(i)-5.3(r)-15.2(o)-9.7(v)]TJ /Span<>> BDC ( )Tj EMC [(R)-20.8(.)1(F)68.8(.)-22.8(, M)-12.9(y)-23.5(a)-10.8(l)-16.1(i)-2.6(n)-7.2(a)]TJ /Span<>> BDC ( )Tj EMC [(S)-9(.)-23.3(A)-22.3(.)-22.9(,)19( )]TJ 0.023 Tc 0.019 Tw -6.346 -1.2 Td [(O)-15.9(r)-19.1(e)-13.8(h)-10.9(o)-10.3(v)]TJ /Span<>> BDC ( )Tj EMC [(I)-10.3(.)-23.9(A)-22.9(.)-23.6(, P)-4.2(e)-22.3(t)-30.8(r)-15.8(o)-10.3(v)]TJ /Span<>> BDC ( )Tj EMC [(L)-29.5(.)12.4(O)11.4(.)-23.5(, I)11.7(v)-28.3(a)-7.6(n)-12(o)-10.3(v)]TJ /Span<>> BDC ( )Tj EMC [(S)-9.6(.)-23.9(A)-23(.)-23.5(, K)-30.4(a)-8.8(p)-13.7(r)-56.4(i)-3.2(n)]TJ /Span<>> BDC ( )Tj EMC [(A)-23(.)1.4(D)16.4(. T)43.2(r)-30.8(a)-7.6(n)-11.2(s)-24.7(a)-7.6(n)-7.8(a)-11.4(l e)-11.5(n)-14.5(d)-11.1(o)-15.8(s)-17.7(c)-6.5(o)-8.3(p)-18.6(i)-5(c m)-14.5(i)-5(c)-22.3(r)-15.8(o)-15.8(s)-8.8(u)-7.6(r)-16.7(g)-14.4(e)-12.1(r)-60.6(y a)-14.4(f)-66.2(t)-24.6(e)-12.1(r r)-30.8(a)-13(d)-15.8(i)-5.1(a)-18.2(t)-46.2(i)-6.8(o)-9.2(n o)-11.8(r c)-10.2(h)-15.1(e)-11.5(m)-12.4(o)-11.8(r)-30.8(a)-13(d)-15.8(i)-5.1(a)-18.2(t)-46.2(i)-6.8(o)-9.1(n t)-26(h)-15.2(e)-12(r)-30.8(a)-8.8(p)-19.6(y f)-25.2(o)-11.8(r)23( )]TJ 0.02 Tc -0.035 Tw 0 -1.2 TD [(r)-18.4(e)-18.3(c)-40.8(t)-36.1(a)-10.7(l)0.5( c)-20.8(a)-6.9(n)-9.3(c)-9(e)-11.3(r)]TJ /Span<>> BDC ( )Tj EMC [(\227 p)-24(e)-18.4(c)-11.3(u)-7.7(l)-16(i)-4.3(a)-9.5(r)-55.7(i)-15(t)-45.5(i)-10.3(e)-22.1(s)0.5( a)-6.8(n)-13.8(d r)-18.4(e)-22(s)-8.1(u)-7.7(l)-14.6(t)-48.2(s)-14.8(. )]TJ /T1_1 1 Tf 0.026 Tc -0.026 Tw [(K)10.6(o)-3.3(lo)-3.4(p)-0.8(rok)-22.5(t)-1(o)-3.4(lo)-6.6(g)-16.4(i)3.4(a)2.5(.)]TJ /T1_3 1 Tf 0.02 Tc -0.035 Tw 24.983 0 Td [( 2)-8.2(0)-3.1(2)9.5(4)11(;)10.5(2)-9.6(3)6.7(\()38.5(1)45(\))15.2(:)-3.1(8)-10.4(2)10.5(\226)-4.5(9)-16.1(0)7.2(.)0.5( \(i)-2.5(n R)-5.8(u)-21.1(s)-21.6(s)-14.8(.)44(\))11.1(. h)-16.5(t)-48.6(t)-28.7(p)-18(s)-7.3(:)2.7(/)85.4(/)37.1(d)-10.3(o)-11.8(i)0.5(.)3.4(o)-11.1(r)-15.9(g)-22.1(/)11.9(1)14.8(0)7.2(.)-4.9(3)8.6(3)-15.1(8)2(7)5.3(8)0.7(/)8.6(2)-8.1(0)10(7)-1.2(3)-12.6(-)42(7)11.4(5)1.1(5)-8.2(6)-26(-)10.5(2)-8.2(0)-3.1(2)9.6(4)-27.8(-)]TJ -0.032 Tc 0.032 Tw -24.983 -1.2 Td [(2)-65.3(3)-68.3(-1)-28.1(-)-80.2(8)-66.2(2)-42.9(-)-59.1(9)-71.8(0)]TJ /T1_2 1 Tf 0.01 Tc 0.04 Tw 0.005 -2.617 Td [(\026\020\021\033\030)5( \020\036\017)5( \013\033\021\033\013\023\030\037\023:)]TJ /T1_1 1 Tf 0 Tc 0.045 Tw 10.62 0 Td ( \201\027\030\031\031\021\013\n \216\025\n\023\031\024\024\026 \201\021\030\ \032\031\031\027\021\026, \240\212\217\037 \025\003. \201.\225.)Tj /Span<>> BDC ( )Tj EMC (\037\020\005\026)Tj /Span<>> BDC ( )Tj EMC [(\227 \f\025\023\025\026\023 \225\210\213\214 \253\217\240\215\037 \032\026\ \030\025\n\023\n\202\025\025\273 )0.5(\240\025\021\016\030\032\026\027\026 \212\n\t\t\025\025, )]TJ 0.023 Tw -10.625 -1.2 Td (\205\023.)Tj /Span<>> BDC ( )Tj EMC (\240\026\032\001\026\023\026 \241\205\013\n\027\026, \030.)Tj /Span<>> BDC ( )Tj EMC (10, \222\026\023\205\204\t\013\026\002 \n\005\023\026\t\024\022, \255\005\ \021\025\021\t\013, 249031, \212\n\t\t\025\002; e-mail: avdeenko.vita@ya\ ndex.ru)Tj /T1_2 1 Tf 0.01 Tc -0.023 Tw 0.005 -1.2 Td [(ADDRESS)5( F)13(OR)5( C)19(ORRESPONDEN)23(CE:)]TJ /T1_1 1 Tf 0 Tc -0.018 Tw 13.969 0 Td [( Violetta A. A)14(v)32.9(deenk)13.1(o, A.T)58(syb Medical R)20(adiological R)21(esearch Centre)]TJ /Span<>> BDC ( )Tj EMC [(\227 Branch of the N)18(ational Medical R)21.1(esearch )]TJ 0.051 Tw -13.974 -1.2 Td [(R)20(adiological Center of the Ministr)-42.9(y of Health of the R)22(ussian F)10.9(ederation, Marshal Zhuk)13(ov st., 10; K)17(alug)12(a region, Obninsk, 249031, R)22(ussia; e-mail: )]TJ 0 Tw T* [(av)33(deenk)13(o.vita@yande)-14.9(x.ru)]TJ 0 -2.792 TD (\200\026\024\026 \033\n\t\024\205\033\023\031\021\025\002)Tj /Span<>> BDC ( )Tj EMC (\227 09.10.2023)Tj /Span<>> BDC ( )Tj EMC 19.488 0 Td (\n\t\023\031 \030\n\032\026\005\n\024\013\025)Tj /Span<>> BDC ( )Tj EMC (\227 22.12.2023)Tj /Span<>> BDC ( )Tj EMC 18.78 0 Td (\032\025\021\002\024\n \013)Tj /Span<>> BDC ( )Tj EMC (\033\205\005\023\025\013\026\203\025\025)Tj /Span<>> BDC ( )Tj EMC (\227 12.02.2024)Tj ( )Tj -38.268 -1.375 Td (Received)Tj /Span<>> BDC ( )Tj EMC (\227 09.10.2023)Tj /Span<>> BDC ( )Tj EMC 19.488 0 Td (Revised)Tj /Span<>> BDC ( )Tj EMC (\227 22.12.2023)Tj /Span<>> BDC ( )Tj EMC 18.78 0 Td (Accepted for publication)Tj /Span<>> BDC ( )Tj EMC (\227 12.02.2024)Tj ET 1 0.68 0 0.12 k /GS0 gs q 1 0 0 1 42.5197 521.7134 cm 0 0 m 0 0 l 0 -11.339 l 42.52 -11.339 l 42.52 0 l h f Q BT 0 0 0 0 k /T1_2 1 Tf 9 0 0 9 45.2263 512.7861 Tm (ABSTRACT)Tj 1 0.68 0 0.12 k /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\033\030\031\030\213\b)-20.9(\035\231\213\233\t \021\032)50(\b)42(\032\231\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj /T1_4 1 Tf 25 0 0 25 512.8394 56.0378 Tm (83)Tj ET endstream endobj 1716 0 obj [1722 0 R] endobj 1717 0 obj <>stream q /GS0 gs /Fm0 Do Q 0 0 0 1 K 1 j 1 J [0 2.997]0 d /GS1 gs q 1 0 0 1 74.3631 131.4104 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 71.3661 131.4104 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q [0 2.997]0 d q 1 0 0 1 74.3631 84.6026 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 71.3661 84.6026 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q BT 0 0 0 1 k /T1_0 1 Tf 10 0 0 10 70.8661 724.8299 Tm (https://doi.org/10.33878/2073-7556-2024-23-1-82-90)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0.023 Tw 19 0 0 19 71.906 695.3259 Tm [(\032)30(\002\013\001\006\013\001\013\007\216\001\020\016 \232\001\201\025\024\220\ \n\002\025\207\220\002\215\002\202\220\017\016\006\n\220\016 \r\024\016\ \013\026)11.1(\016\007\216\006)-10(\026\r\013 )]TJ 2.896 -1.105 Td [(\221\002\220\022)-23.3(\002\013\n\016 \221\002\205\024\025\203 \n\220\n\220 \221\025\006)-9.9(\007\016 \007\215\017\016\r\025\203 \220\007\220 )]TJ -0.927 -1.105 Td [(\207\220\024\220\025\007\215\017\016\r\025\203 \026)11(\016\002\013\221\220\220\022)-23.3(\236 \001\212\013\001\006\020 \220\022)-23.3(\002\016\222)21(\215\007\216)20.9(\026)11.1(\013\026\020)]TJ 0 0 0 1 k /GS1 gs 0 Tw 14 0 0 14 70.8661 628.822 Tm [(\213\016\r\025\007\216\006\n\220\207\022)-23.2(\b)-31(.\b)-31(.)]TJ 8.162 0 0 8.162 168.5325 633.484 Tm (1)Tj 0.023 Tw 14 0 0 14 173.1684 628.822 Tm [(, \214\002\025\201\006\n\220\203\022)-23.2(\b)-31(.\033)124(.)]TJ 0 Tw 8.162 0 0 8.162 261.8373 633.484 Tm (1)Tj 0.023 Tw 14 0 0 14 266.4733 628.822 Tm [(, \b\r\201\016\016\001\n)10.1(\025\022)-23.3(\004.\b)-31(.)]TJ 0 Tw 8.162 0 0 8.162 358.2218 633.484 Tm (1)Tj 0.023 Tw 14 0 0 14 362.8578 628.822 Tm [(, \034\025\017\215\016\r\022)-23.2(\032.\034.)]TJ 0 Tw 8.162 0 0 8.162 439.165 633.484 Tm (1)Tj 14 0 0 14 443.801 628.822 Tm (, )Tj -26.638 -1.143 Td [(\005\220\207)10(\013\007\016\r\013\022)-23.2(\200.\200.)]TJ 8.162 0 0 8.162 169.7373 617.484 Tm (1)Tj 0.023 Tw 14 0 0 14 174.3732 612.822 Tm [(, \214\016\002\016\222\025\r\006\n\013\205\022)-23.2(\032.\034.)]TJ 0 Tw 8.162 0 0 8.162 281.5639 617.484 Tm (1)Tj 0.023 Tw 14 0 0 14 286.1999 612.822 Tm [(, \211\220\f\220\002\025\r\022)-23.2(\033)124(.\210.)]TJ 0 Tw 8.162 0 0 8.162 372.1671 617.484 Tm (1)Tj 0.023 Tw 14 0 0 14 376.8031 612.822 Tm [(, \005\205\007\220\001\013\022)-23.2(\021.\b)-31(.)]TJ 0 Tw 8.162 0 0 8.162 459.648 617.484 Tm (1)Tj 14 0 0 14 464.284 612.822 Tm (, )Tj -28.101 -1.143 Td [(\036\002\016)21(\207\025\r\022)-23.2(\030.\b)-31(.)]TJ 8.162 0 0 8.162 146.5812 601.484 Tm (1)Tj 0.023 Tw 14 0 0 14 151.2171 596.822 Tm [(, \034\016\026\002\025\r\022)-23.2(\035.\036.)]TJ 0 Tw 8.162 0 0 8.162 232.0042 601.484 Tm (1)Tj 0.023 Tw 14 0 0 14 236.6402 596.822 Tm [(, \030\r\013\001\025\r\022)-23.2(\021.\b)-31(.)]TJ -0.069 Tc 0.069 Tw 8.162 0 0 8.162 317.749 601.484 Tm [(1,)-69(3)]TJ 0 Tc 0.023 Tw 14 0 0 14 329.0696 596.822 Tm [(, \037)41(\013\221\002\220\001\022)-23.3(\b)-30.9(.\255.)]TJ 0 Tw 8.162 0 0 8.162 409.8849 601.484 Tm (2,3)Tj 5.83 0 0 5.83 70.8661 582.4827 Tm (1)Tj 0.023 Tw 10 0 0 10 74.1775 579.1527 Tm [(\005\016\201\220\227\220\001\006\n\220\203 \002\013\201\220\025\007\025\202\ \220\017\016\006\n\220\203 \001\013\215\017\001\020\203 \227\016\001\026\ \002 \220\024.\022)-23.3(\b)-31(.\210.\022)-23.2(\226\020\f\013\022)-23.3(\236 \225\220\007\220\013\007 \210\031\214)42(\240 \253\213\005\030\226 \002\013\201\220\025\007\025\202\220\220\273 )]TJ -0.331 -1.2 Td [(\005\220\001\222\201\002\013\r\013 \033\025\006\006\220\220 \(\215\007.\022\ )-23.3(\005\013\002\013\007\013 \223)20(\215\n)10(\025\r\013, \201.\022)-23.3(1)75.1(0, \037)41(\013\007\215\217\006\n\013\205 \025\f\007\013\006)-10(\026\216, \202)62(.\022)-23.3(\036\f\001\220\001\006\n, 2)69(4903)138(1)69(, \033\025\006\006\220\205\))]TJ 0 Tw ( )Tj 5.83 0 0 5.83 70.8661 558.4827 Tm (2)Tj 0.023 Tw 10 0 0 10 74.1775 555.1527 Tm [(\210\031\214)42(\240 \253\213\005\030\226 \002\013\201\220\025\007\025\202\220\220\273 \005\ \220\001\222\201\002\013\r\013 \033\025\006\006\220\220 \(\215\007.\022)-23.3(\037)31(\025\002\025\007\016\r\013, \201.\022)-23.3(4, \037)41(\013\007\215\217\006\n\013\205 \025\f\007\013\006)-10(\026\216, \202)62(.\022)-23.3(\036\f\001\220\001\006\n, )]TJ -0.331 -1.2 Td [(2)69(4903)138(1)69(, \033\025\006\006\220\205\))]TJ 0 Tw ( )Tj 5.83 0 0 5.83 70.8661 534.4828 Tm (3)Tj 0.023 Tw 10 0 0 10 74.1775 531.1528 Tm [(\210\031)83(\b\036)20(\240 \004\036 \253\033\025\006\006\220\203\006\n\220\203 \215\001\220\r\016\ \002\006\220\026)11.1(\016\026 \201\002\215\217\f\020 \001\013\002\025\201\025\r\273 \(\215\007\ .\022)-23.2(\005\220\n)-10(\007\215)21(\207\025-\005\013\n)-9.9(\007\013\205, \201.\022)-23.3(6, \202)62(.\022)-23.4(\005\025\006\n\r\013, 1)212(1)138(7)127(1)138(9)34(8, )]TJ 0 Tw -0.331 -1.2 Td (\033\025\006\006\220\205\))Tj /T1_0 1 Tf 0.101 Tw 9 0 0 9 119.0551 500.6489 Tm (\216\216\036\200\036\217\215\036: \t\024\026\021\030\026\032\024\n\003 \023\ \031\006\031\021\025\002 \005\n\023\022\021\020\004 \003\031\t\024\021\n\ \032\026\t\033\032\n\t\024\032\026\021\031\021\021\020\003\025 \f\n\032\003\ \026\003\025 \032\026\013\026 \033\032\002\003\n\017 \013\025\001\013\025\ \(\212\222\) )Tj 0.217 Tw 0 -1.111 TD (\002\027\023\002\031\024\t\002 \033\032\025\003\031\021\031\021\025\031 \ \004\025\003\025\n\023\205\006\031\027\n\017 \024\031\032\026\033\025\025\ \(\206\035\220\), \023\025\005\n \025\021\024\031\021\t\025\027\021\020\ \004 \032\031\204\025\003\n\027 \023\205\006\031\027\n\017 \024\031\032\026\ \033\025\025 \(\035\220\) )Tj 0.02 Tw T* (\t)Tj /Span<>> BDC ( )Tj EMC 0.645 0 Td [(\n\024\t\032\n\006\031\021\021\020\003 )0.5(\004\025\032\205\032\202\025\006\031\t\013\025\003 )0.6(\027\003\031\001\026\024\031\023\022\t\024\027\n\003. )0.7(\032\025)]TJ /Span<>> BDC ( )Tj EMC 21.908 0 Td [(\r\024\n\003 )0.6(\027)]TJ /Span<>> BDC ( )Tj EMC 3.168 0 Td [(10\22625% )0.5(\t\023\205\006\026\031\027 )0.5(\205)]TJ /Span<>> BDC ( )Tj EMC 7.596 0 Td [(\033\026\203\025\031\021\024\n\027 )0.5(\021\026)]TJ /Span<>> BDC ( )Tj EMC 6.09 0 Td [(\f\n\021\031 )0.6(\023\031\006\031\021\025\002 )]TJ 0.124 Tw -39.408 -1.111 Td (\n\024\003\031\006\026\031\024\t\002 \033\n\023\021\n\031 \025\t\006\031\ \016\021\n\027\031\021\025\031 \n\033\205\004\n\023\025. \207\n\027\032\031\ \003\031\021\021\020\031 \033\n\030\004\n\030\020 \013)Tj /Span<>> BDC ( )Tj EMC (\027\031\030\031\021\025\007 \t\023\205\006\026\031\027 \t)Tj /Span<>> BDC ( )Tj EMC (\004\n\032\n\001\025\003 \n\024\027\031\024\n\003 )Tj 0.067 Tw T* (\033\032\031\030\033\n\023\026\202\026\007\024 \n\032\202\026\021\n\t\n\004\ \032\026\021\002\007\211\031\031 \023\031\006\031\021\025\031 \205)Tj /Span<>> BDC ( )Tj EMC (\033\026\203\025\031\021\024\n\027 \t)Tj /Span<>> BDC ( )Tj EMC (\033\n\023\021\020\003 \013\023\025\021\025\006\031\t\013\025\003 \n\024\ \027\031\024\n\003 \(cCR\), \033\n\030 \013\n\024\n)Tj 0 Tw (-)Tj 0.201 Tw 0 -1.111 TD (\032\020\003 \033\n\030\032\026\016\205\003\031\027\026\031\024\t\002 \030\ \025\021\026\003\025\006\031\t\013\n\031 \021\026\005\023\007\030\031\021\ \025\031 \016\026)Tj /Span<>> BDC ( )Tj EMC (\033\026\203\025\031\021\024\n\003, \023\025\005\n \027\020\033\n\023\021\ \031\021\025\031 \023\n\013\026\023\022\021\n\202\n \025\t\t\031\006\031\ \021\025\002 )Tj 0.02 Tw 0 -1.111 TD [(\016\n\021\020 )0.6(\032\205\005\203\026 )0.5(\021\026)]TJ /Span<>> BDC ( )Tj EMC 6.148 0 Td [(\003\031\t\024\031 )0.6(\032\026\021\031\031 )0.6(\t\205\211\031\t\024\027\n\027\026\027\001\031\017 )0.6(\n\033\205\004\n\023\025 )0.6(\027)]TJ /Span<>> BDC ( )Tj EMC 17.07 0 Td [(\t\023\205\006\026\002\004 )0.6(\033\n\006\024\025 )0.6(\033\n\023\021\n\202\n )0.6(\013\023\025\021\025\006\031\t\013\n\202\n )0.6(\n\024\027\031\024\026 )0.5(\(nCR\).)]TJ 0.056 Tw -23.218 -1.111 Td (\037\036\035\034 \215\207\207\035\036\200\255\216\201\217\215\243: \026\021\ \026\023\025\016 \032\031\016\205\023\022\024\026\024\n\027 \023\031\006\ \031\021\025\002 \005\n\023\022\021\020\004 \212\222 \t)Tj /Span<>> BDC ( )Tj EMC (\004\n\032\n\001\025\003 \n\024\027\031\024\n\003 \021\026)Tj /Span<>> BDC ( )Tj EMC (\035\220/\206\035\220, \013\n\024\n\032\020\003 )Tj 0.023 Tw T* (\005\020\023\025 \027\020\033\n\023\021\031\021\020 \024\032\026\021\t\026\ \021\026\023\022\021\020\031 \r\021\030\n\003\025\013\032\n\004\025\032\205\ \032\202\025\006\031\t\013\025\031 \027\003\031\001\026\024\031\023\022\t\ \024\027\026 \(\220\230\240\).)Tj -0.013 Tw T* (\201\037\215\036\217\220\235 \215)Tj /Span<>> BDC ( )Tj EMC (\240\036\220\255\200\235: \027)Tj /Span<>> BDC ( )Tj EMC (\033\031\032\025\n\030 \t)Tj /Span<>> BDC ( )Tj EMC (2019 \033\n)Tj /Span<>> BDC ( )Tj EMC (2023 \202\202. \004\025\032\205\032\202\025\006\031\t\013\025\031 \027\003\ \031\001\026\024\031\023\022\t\024\027\026 \027)Tj /Span<>> BDC ( )Tj EMC (\n\005\b\031\003\031 \220\230\240 \033\n\t\023\031 \035\220/\206\035\220\ )Tj 0.099 Tw T* (\005\020\023\025 \027\020\033\n\023\021\031\021\020 20 \005\n\023\022\021\ \020\003 \t)Tj /Span<>> BDC ( )Tj EMC (\026\030\031\021\n\013\026\032\203\025\021\n\003\n\017 \033\032\002\003\n\ \017 \013\025\001\013\025. \214)Tj /Span<>> BDC ( )Tj EMC (\027\t\031\004 \033\026\203\025\031\021\024\n\027 \n\033\205\004\n\023\025\ \032\026\t\033\n\023\026\202\026\023\025\t\022 )Tj 0.167 Tw T* (\027)Tj /Span<>> BDC ( )Tj EMC (\030\025\t\024\026\023\022\021\020\004 \n\024\030\031\023\026\004 \033\032\ \002\003\n\017 \013\025\001\013\025, \006\024\n \033\032\031\030\033\n\023\ \026\202\026\023\n \027\020\033\n\023\021\031\021\025\031 \023\025\005\n\ \005\032\007\001\021\n-\033\032\n\003\031\204\021\n\t\024\021\n\017 \r\013\ \t)Tj 0 Tw (-)Tj 0.038 Tw T* (\024\025\032\033\026\203\025\025, \023\025\005\n \n\006\031\021\022 \021\ \025\016\013\n\017 \033\031\032\031\030\021\031\017 \032\031\016\031\013\ \203\025\025 \033\032\002\003\n\017 \013\025\001\013\025. \240\031\030\025\ \026\021\026 \025\021\024\031\032\027\026\023\026 \003\031\204\030\205 \035\ \220 \025)Tj /Span<>> BDC ( )Tj EMC (\n\033\031\032\026\203\025\031\017 )Tj 0.059 Tw T* (\t\n\t\024\026\027\025\023\026 22 \(12\22678\) \021\031\030\031\023\025.\ \214)Tj /Span<>> BDC ( )Tj EMC (5)Tj /Span<>> BDC ( )Tj EMC (\(25,0%\) \005\n\023\022\021\020\004, \027\013\023\007\006\031\021\021\020\ \004 \027)Tj /Span<>> BDC ( )Tj EMC (\025\t\t\023\031\030\n\027\026\021\025\031, \005\020\023 \016\026\032\031\ \202\025\t\024\032\025\032\n\027\026\021 cCR )Tj 0.023 Tw 0 -1.111 TD (\021\026)Tj /Span<>> BDC ( )Tj EMC (\033\032\n\027\031\030\031\021\021\n\031 \021\031\n\026\030\b\007\027\026\ \021\024\021\n\031 \023\031\006\031\021\025\031. \216)Tj /Span<>> BDC ( )Tj EMC (15 \t\023\205\006\026\002\004 \220\230\240 \005\020\023 \027\020\033\n\023\ \021\031\021 \033\026\203\025\031\021\024\026\003 \t)Tj /Span<>> BDC ( )Tj EMC (nCR.)Tj 0.079 Tw 0 -1.111 TD (\212\036\221\214\035\034\220\201\220\235: \003\031\030\025\026\021\026 \033\ \032\n\030\n\023\204\025\024\031\023\022\021\n\t\024\025 \004\025\032\205\ \032\202\025\006\031\t\013\n\202\n \027\003\031\001\026\024\031\023\022\t\ \024\027\026 \t\n\t\024\026\027\025\023\026 117 \003\025\021\205\024, \n\ \005\b\031\003\026 )Tj 0.064 Tw T* (\013\032\n\027\n\033\n\024\031\032\025)Tj /Span<>> BDC ( )Tj EMC [(\227 40 \003\023. \255\t\023\n\204\021\031\021\021\n\031 \024\031\006\031\ \021\025\031 \033\n\t\023\031\n\033\031\032\026\203\025\n\021\021\n\202\n\ )0.5(\033\031\032\025\n\030\026 \021\026\005\023\007\030\026\023\n\t\022 \205\ )]TJ /Span<>> BDC ( )Tj EMC (4)Tj /Span<>> BDC ( )Tj EMC (\(20,0%\) \005\n\023\022)Tj 0 Tw (-)Tj -0.033 Tw T* (\021\020\004, \t\032\031\030\025 \013\n\024\n\032\020\004 \021\026\025\005\ \n\023\031\031 \t\031\032\022\031\016\021\020\003 \n\t\023\n\204\021\031\ \021\025\031\003 \002\027\023\002\023\026\t\022 \021\031\t\n\t\024\n\002\ \024\031\023\022\021\n\t\024\022 \001\027\n\027 \205\001\025\024\n\202\n\ \030\031\f\031\013\024\026 )Tj 0.056 Tw T* (\013\025\001\013\025)Tj /Span<>> BDC ( )Tj EMC (\227 \205)Tj /Span<>> BDC ( )Tj EMC (3)Tj /Span<>> BDC ( )Tj EMC (\(15,0%\) \033\026\203\025\031\021\024\n\027. \217\031\005\023\026\202\n\ \033\032\025\002\024\021\020\031 \f\026\013\024\n\032\020 \033\032\n\202\ \021\n\016\026 \005\020\023\025 \027\020\002\027\023\031\021\020 \205)Tj /Span<>> BDC ( )Tj EMC (7)Tj /Span<>> BDC ( )Tj EMC (\(35%\) \033\026\203\025\031\021)Tj 0 Tw (-)Tj 0.132 Tw T* (\024\n\027, \033\032\025)Tj /Span<>> BDC ( )Tj EMC (\r\024\n\003 \016\026\027\031\032\001\026\007\211\026\002 \220\240\230 \005\ \020\023\026 \027\020\033\n\023\021\031\021\026 \024\n\023\022\013\n \205\ )Tj /Span<>> BDC ( )Tj EMC (2)Tj /Span<>> BDC ( )Tj EMC (\(28,6%\) \025\016)Tj /Span<>> BDC ( )Tj EMC (\021\025\004. \216)Tj /Span<>> BDC ( )Tj EMC (\n\t\024\026\023\022\021\020\004 \013\023\025\021\025\006\031\t\013\025\004\ )Tj 0.103 Tw T* (\t\025\024\205\026\203\025\002\004 \033\032\n\027\n\030\025\023\n\t\022 \ \026\013\024\025\027\021\n\031 \030\025\021\026\003\025\006\031\t\013\n\031\ \021\026\005\023\007\030\031\021\025\031 \016\026)Tj /Span<>> BDC ( )Tj EMC (\005\n\023\022\021\020\003\025)Tj /Span<>> BDC ( )Tj EMC (\227 \021\025 \027)Tj /Span<>> BDC ( )Tj EMC (\n\030\021\n\003 \t\023\205\006\026\031 \003\031\t\024\021\n\202\n )Tj 0.057 Tw T* (\032\031\203\025\030\025\027\026 \n\033\205\004\n\023\025 \027\020\002\027\ \023\031\021\n \021\031 \005\020\023\n. \032\025)Tj /Span<>> BDC ( )Tj EMC (\003\031\030\025\026\021\031 \021\026\005\023\007\030\031\021\025\002 31\ ,5 \(3\22654\) \003\031\t\002\203\031\027 \033\032\025\016\021\026\013\025\ \n\024\030\026\023\031\021\021\n\202\n )Tj 0.087 Tw T* [(\003\031\024\026\t\024\026\016\025\032\n\027\026\021\025\002 )0.5(\005\020\023\025 \016\026\032\031\202\025\t\024\032\025\032\n\027\026\021\ \020 )0.5(\027)]TJ /Span<>> BDC ( )Tj EMC (2)Tj /Span<>> BDC ( )Tj EMC (\(10,0%\) \t\023\205\006\026\002\004. \240\031\t\024\021\020\017 \032\031\ \203\025\030\025\027 \021\026)Tj /Span<>> BDC ( )Tj EMC (\t\032\n\013\031 12,3 \003\031\t\002\203\031\027 )Tj 0.114 Tw 0 -1.111 TD [(\005\020\023 )0.6(\027\020\002\027\023\031\021 )0.6(\027)]TJ /Span<>> BDC ( )Tj EMC 6.581 0 Td [(\n\030\021\n\003 )0.6(\t\023\205\006\026\031 )0.6(\(5,0%\). )0.5(\222\205\003\205\023\002\024\025\027\021\026\002 )0.7(\024\032\031\004\023\031\024\021\002\002 )0.6(\006\026\t\024\n\024\026 )0.6(\003\031\t\024\021\020\004 )0.5(\032\031\203\025\030\025\027\n\027 )0.5(\t\n\t\024\026\027\025\023\026 )]TJ 0.066 Tw -6.581 -1.111 Td (6,2)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (6,1%. \255\005\211\026\002 \025)Tj /Span<>> BDC ( )Tj EMC (\005\031\016\032\031\203\025\030\025\027\021\026\002 \024\032\031\004\023\ \031\024\021\002\002 \027\020\204\025\027\026\031\003\n\t\024\022 \t\n\t\ \024\026\027\025\023\025, \t\n\n\024\027\031\024\t\024\027\031\021\021\n\ , 83,3)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (10,8% )Tj 0.023 Tw 0 -1.111 TD (\025)Tj /Span<>> BDC ( )Tj EMC (80,4)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (10,4%, \026)Tj /Span<>> BDC ( )Tj EMC (\027\020\204\025\027\026\031\003\n\t\024\022 \005\031\016 \t\024\n\003\020\ )Tj /Span<>> BDC ( )Tj EMC (\227 92,9)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (6,9%.)Tj -0.011 Tw T* [(\221\201\222\035\223\224\036\217\215\036: )0.5(\021\031\t\003\n\024\032\002 )0.5(\021\026)]TJ /Span<>> BDC ( )Tj EMC 11.607 0 Td [(\024\n, )0.5(\006\024\n \220\230\240 )0.5(\205)]TJ /Span<>> BDC ( )Tj EMC [(\005\n\023\022\021\020\004 )0.5(\212\222 )0.5(\033\n\t\023\031 \035\220)]TJ /Span<>> BDC ( )Tj EMC 15.198 0 Td (\227 \r\f\f\031\013\024\025\027\021\020\017 \025)Tj /Span<>> BDC ( )Tj EMC (\005\031\016\n\033\026\t\021\020\017 \003\031\024\n\030 \023\031\006\031\ )Tj 0 Tw (-)Tj 0.065 Tw -26.805 -1.111 Td (\021\025\002, \033\032\025\003\031\021\031\021\025\031 \031\202\n \205)Tj /Span<>> BDC ( )Tj EMC (\033\026\203\025\031\021\024\n\027 \t)Tj /Span<>> BDC ( )Tj EMC (cCR \t)Tj /Span<>> BDC ( )Tj EMC (\203\031\023\022\007 \033\n\030\024\027\031\032\204\030\031\021\025\002 \ \033\n\023\021\n\202\n \n\024\027\031\024\026 \021\031\203\031\023\031\t\ \n\n\005\032\026\016\021\n \025)Tj /Span<>> BDC ( )Tj EMC (\021\031\t\031\024 )Tj 0.201 Tw T* (\027)Tj /Span<>> BDC ( )Tj EMC (\t\031\005\031 \023\025\001\021\025\017 \032\025\t\013 \033\n\t\023\031\n\ \033\031\032\026\203\025\n\021\021\020\004 \n\t\023\n\204\021\031\021\025\ \017, \027\n\016\003\n\204\021\020\004 \f\205\021\013\203\025\n\021\026\023\ \022\021\020\004 \021\026\032\205\001\031\021\025\017. \255\t\021\n\027\021\ \020\003 )Tj 0.14 Tw 0 -1.111 TD (\033\n\013\026\016\026\021\025\031\003 \013)Tj /Span<>> BDC ( )Tj EMC (\033\032\025\003\031\021\031\021\025\007 \220\230\240 \033\n\t\023\031 \035\ \220/\206\035\220 \002\027\023\002\031\024\t\002 nCR, \027)Tj /Span<>> BDC ( )Tj EMC (\t\023\205\006\026\031 \013\n\024\n\032\n\202\n \023\n\013\026\023\022\021\ \n\031 \025\t\t\031\006\031\021\025\031 \016\n\021\020 )Tj 0.131 Tw 0 -1.111 TD [(\032\205\005\203\026 \033\n\016\027\n\023\002\031\024 \021\031 \024\n\023\ \022\013\n \n\033\032\031\030\031\023\025\024\022 \025\004 \033\026\024\n\ \003\n\032\f\n\023\n\202\025\006\031\t\013\205\007 )0.5(\033\032\025\032\n\030\205 \025)]TJ /Span<>> BDC ( )Tj EMC (\024\026\013\024\025\013\205 \023\031\006\031\021\025\002, \021\n \025)Tj /Span<>> BDC ( )Tj EMC (\030\023\002 )Tj 0.041 Tw T* (\005\n\023\022\001\025\021\t\024\027\026 \033\026\203\025\031\021\024\n\027\ \002\027\023\002\031\024\t\002 \032\026\030\025\013\026\023\022\021\020\ \003 \004\025\032\205\032\202\025\006\031\t\013\025\003 \027\003\031\001\ \026\024\031\023\022\t\024\027\n\003 \t)Tj /Span<>> BDC ( )Tj EMC (\n\024\021\n\t\025\024\031\023\022\021\n \021\031\027\020\t\n)Tj 0 Tw (-)Tj 0.023 Tw T* (\013\025\003 \032\025\t\013\n\003 \003\031\t\024\021\n\202\n \032\031\203\ \025\030\025\027\026.)Tj /T1_2 1 Tf 0.01 Tc 0.033 Tw 8 0 0 8 70.906 165.3796 Tm [(\037\036\035\034\033\032\031\033)5( \030\036\027\032\026:)]TJ /T1_0 1 Tf 0 Tc 0.038 Tw 8.508 0 Td ( \032\026\013 \033\032\002\003\n\017 \013\025\001\013\025, \024\032\026\021\ \t\026\021\026\023\022\021\026\002 \r\021\030\n\t\013\n\033\025\006\031\t\ \013\026\002 \003\025\013\032\n\004\025\032\205\032\202\025\002, \004\025\ \003\025\n\023\205\006\031\027\026\002 \024\031\032\026\033\025\002, \023\ \205\006\031\027\026\002 \024\031\032\026\033\025\002, \033\n\023)Tj 0 Tw (-)Tj 0.023 Tw -8.513 -1.2 Td (\021\020\017 \013\023\025\021\025\006\031\t\013\025\017 \n\024\027\031\024\ , \033\n\006\024\025 \033\n\023\021\020\017 \013\023\025\021\025\006\031\ \t\013\025\017 \n\024\027\031\024)Tj /T1_2 1 Tf 0.01 Tc 0.018 Tw 0.005 -1.909 Td [(\037\027\025\024\036\023\037\022)5( \023\025\022\033\021\033\030\027\032:)]TJ /T1_0 1 Tf 0 Tc 0.023 Tw 10.401 0 Td ( \026\027\024\n\032\020 \016\026\002\027\023\002\007\024 \n\005 \n\024\t\ \205\024\t\024\027\025\025 \013\n\021\f\023\025\013\024\026 \025\021\024\ \031\032\031\t\n\027)Tj /T1_2 1 Tf 0.033 Tc -0.015 Tw -10.401 -2.617 Td [(\020\036\017)4.7( )0.5(\016\023\022\023\021\027\032\026\025\023\017:)]TJ /T1_3 1 Tf 0.023 Tc -0.01 Tw 9.157 0 Td [( )0.5(\203\036\r\024\035\034\f\022\017\b)]TJ /Span<>> BDC ( )Tj EMC 5.551 0 Td [(\202.\202., )0.5(\207\030\024\007\f\022\017\005)]TJ /Span<>> BDC ( )Tj EMC 6.665 0 Td [(\202.\217., )0.5(\202\r\007\036\036\027\022\024)]TJ /Span<>> BDC ( )Tj EMC 6.565 0 Td [(\200.\202., )0.5(\215\024\004\031\036\r)]TJ /Span<>> BDC ( )Tj EMC 5.581 0 Td [(\230.\215., )0.5(\204\017\b\026\035\036\r\026)]TJ /Span<>> BDC ( )Tj EMC 6.604 0 Td [(\236.\236., )0.5(\207\036\030\036\024\r\f\022\026\016)]TJ /Span<>> BDC ( )Tj EMC 8.466 0 Td [(\230.\215., )0.5(\003\017\002\017\030\024\r)]TJ /Span<>> BDC ( )Tj EMC 6.085 0 Td [(\217.\205.,)23( )]TJ -0.015 Tw -54.678 -1.2 Td (\204\016\035\017\027\026)Tj /Span<>> BDC ( )Tj EMC (\221.\202., \210\030\036\b\024\r)Tj /Span<>> BDC ( )Tj EMC (\222.\202., \215\036\021\030\024\r)Tj /Span<>> BDC ( )Tj EMC (\214.\210., \222\r\026\027\024\r)Tj /Span<>> BDC ( )Tj EMC (\221.\202., \025\026\023\030\017\027)Tj /Span<>> BDC ( )Tj EMC (\202.\212. \230\030\026\027\f\026\027\026\035\034\027\t\036 \220\027\007\ \024\n\017\022\030\024\b\017\030\031\030\020\017\004\036\f\022\017\036 \r\ \n\036\001\026\021\036\035\034\f\021\r\026 \023\030\017)Tj /Span<>> BDC ( )Tj EMC [(\030\026\022\036)23( )]TJ 0.052 Tw 0 -1.2 TD (\023\030\016\n\024\005 \022\017\001\022\017 \023\024\f\035\036 \035\031\004\ \036\r\024\005 \017\035\017 \b\017\n\017\024\035\031\004\036\r\024\005 \021\ \036\030\026\023\017\017)Tj /Span<>> BDC ( )Tj EMC (\227 \027\033\026\027\f\t \017)Tj /Span<>> BDC ( )Tj EMC (\030\036\031\035\034\021\026\021\t. )Tj /T1_0 1 Tf -0.023 Tw (\222\n\023\n\033\032\n\013\024\n\023\n\202\025\002.)Tj /T1_3 1 Tf 0.052 Tw ( 2024; \021.)Tj /Span<>> BDC ( )Tj EMC (23, \225)Tj /Span<>> BDC ( )Tj EMC (1, \f.)Tj /Span<>> BDC ( )Tj EMC [(82\22690.)23( )]TJ -0.023 Tw T* (https://doi.org/10.33878/2073-7556-2024-23-1-82-90)Tj ET 1 0.68 0 0.12 k /GS0 gs q 1 0 0 1 70.8661 509.1533 cm 0 0 m 0 0 l 0 -11.339 l 42.52 -11.339 l 42.52 0 l h f Q BT 0 0 0 0 k /T1_2 1 Tf 0 Tc 0 Tw 9 0 0 9 76.0071 500.226 Tm (\021\033\r\035\f\033)Tj 1 0.68 0 0.12 k /T1_1 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\033\030\031\030\213\b)-20.9(\035\231\213\233\t \021\032)50(\b)42(\032\231\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj -51.938 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 23, \023\0221)69(, 202)69(4)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 23, \023\0221)69(, 202)69(4)]TJ /T1_4 1 Tf 25 0 0 25 28.1276 56.0378 Tm (82)Tj ET q 0 g 0 G 0 j 0 J /Fm1 Do Q 0 0 0 0 k 396.85 725.67 59.155 11.338 re f /PlacedPDF /MC0 BDC q 397.481 736.808 m 397.242 736.808 397.049 736.616 397.049 736.376 c 397.049 736.376 l 397.049 726.285 l 397.049 726.045 397.242 725.853 397.481 725.853 c 397.481 725.853 l 455.382 725.853 l 455.62 725.853 455.815 726.045 455.815 726.285 c 455.815 726.285 l 455.815 736.376 l 455.815 736.616 455.62 736.808 455.382 736.808 c 455.382 736.808 l h W n q 0 g -0.0000005 -10.9560913 -10.9560913 0.0000005 426.4320445 736.8086309 cm BX /Sh0 sh EX Q Q q 396.85 725.67 59.155 11.337 re W n 0 0 0 0.84 k q 1 0 0 1 413.5634 732.4249 cm 0 0 m -0.025 0.1 -0.063 0.196 -0.112 0.287 c -0.157 0.374 -0.218 0.451 -0.292 0.515 c -0.37 0.582 -0.46 0.632 -0.558 0.664 c -0.669 0.701 -0.786 0.719 -0.903 0.717 c -1.076 0.722 -1.247 0.681 -1.4 0.6 c -1.536 0.526 -1.652 0.42 -1.74 0.292 c -1.83 0.158 -1.895 0.008 -1.934 -0.149 c -2.018 -0.48 -2.018 -0.827 -1.934 -1.158 c -1.896 -1.316 -1.83 -1.466 -1.74 -1.602 c -1.653 -1.731 -1.536 -1.837 -1.4 -1.912 c -1.247 -1.993 -1.076 -2.033 -0.903 -2.029 c -0.774 -2.032 -0.647 -2.006 -0.528 -1.955 c -0.427 -1.906 -0.337 -1.837 -0.263 -1.753 c -0.185 -1.665 -0.124 -1.563 -0.082 -1.453 c -0.034 -1.338 0 -1.218 0.019 -1.094 c 0.635 -1.094 l 0.624 -1.297 0.578 -1.497 0.497 -1.684 c 0.421 -1.857 0.312 -2.015 0.175 -2.146 c 0.039 -2.277 -0.123 -2.379 -0.3 -2.446 c -0.492 -2.519 -0.695 -2.555 -0.9 -2.552 c -1.15 -2.557 -1.397 -2.506 -1.625 -2.404 c -1.829 -2.307 -2.01 -2.169 -2.157 -1.997 c -2.308 -1.821 -2.423 -1.617 -2.497 -1.397 c -2.655 -0.924 -2.655 -0.412 -2.497 0.061 c -2.423 0.281 -2.307 0.485 -2.157 0.661 c -2.01 0.833 -1.829 0.973 -1.625 1.07 c -1.398 1.174 -1.15 1.226 -0.9 1.222 c -0.707 1.223 -0.515 1.196 -0.329 1.14 c -0.159 1.088 0.001 1.006 0.144 0.898 c 0.278 0.793 0.39 0.662 0.473 0.513 c 0.562 0.349 0.615 0.167 0.629 -0.019 c 0 -0.019 l 0 0 l f Q q 1 0 0 1 414.6923 733.5723 cm 0 0 m 0.584 0 l 0.584 -1.328 l 0.662 -1.204 0.771 -1.103 0.9 -1.033 c 1.046 -0.951 1.213 -0.91 1.381 -0.914 c 1.627 -0.9 1.869 -0.979 2.058 -1.137 c 2.234 -1.312 2.325 -1.556 2.305 -1.803 c 2.305 -3.596 l 1.716 -3.596 l 1.716 -1.976 l 1.724 -1.817 1.678 -1.66 1.585 -1.53 c 1.486 -1.43 1.347 -1.379 1.206 -1.392 c 1.114 -1.39 1.024 -1.408 0.94 -1.445 c 0.865 -1.479 0.798 -1.529 0.744 -1.591 c 0.687 -1.656 0.645 -1.73 0.616 -1.812 c 0.586 -1.896 0.571 -1.986 0.571 -2.077 c 0.571 -3.615 l 0 -3.615 l 0 0 l f Q q 1 0 0 1 418.0385 731.1235 cm 0 0 m 0 -0.099 0.014 -0.198 0.043 -0.292 c 0.069 -0.382 0.112 -0.466 0.17 -0.54 c 0.229 -0.611 0.304 -0.669 0.388 -0.709 c 0.486 -0.754 0.594 -0.776 0.702 -0.773 c 0.845 -0.78 0.987 -0.742 1.108 -0.664 c 1.217 -0.582 1.296 -0.468 1.336 -0.337 c 1.881 -0.337 l 1.827 -0.603 1.675 -0.838 1.456 -0.996 c 1.35 -1.073 1.231 -1.131 1.105 -1.169 c 0.971 -1.208 0.831 -1.229 0.691 -1.227 c 0.509 -1.227 0.328 -1.191 0.16 -1.121 c 0.007 -1.063 -0.13 -0.972 -0.244 -0.855 c -0.356 -0.73 -0.44 -0.583 -0.491 -0.422 c -0.548 -0.243 -0.576 -0.056 -0.574 0.133 c -0.575 0.313 -0.545 0.493 -0.486 0.664 c -0.426 0.826 -0.335 0.974 -0.22 1.102 c 0.004 1.375 0.338 1.534 0.691 1.535 c 0.883 1.539 1.072 1.495 1.243 1.408 c 1.402 1.326 1.541 1.209 1.649 1.067 c 1.759 0.922 1.838 0.757 1.883 0.582 c 1.932 0.396 1.945 0.203 1.92 0.013 c 0 0.013 l 0 0 l 1.342 0.377 m 1.335 0.468 1.315 0.557 1.283 0.643 c 1.253 0.724 1.209 0.798 1.153 0.863 c 1.097 0.922 1.03 0.97 0.957 1.004 c 0.874 1.043 0.783 1.063 0.691 1.062 c 0.6 1.062 0.509 1.044 0.425 1.009 c 0.345 0.976 0.273 0.926 0.213 0.863 c 0.153 0.799 0.105 0.724 0.072 0.643 c 0.037 0.559 0.017 0.468 0.014 0.377 c 1.355 0.377 l h f Q q 1 0 0 1 422.1581 731.7051 cm 0 0 m -0.012 0.144 -0.082 0.276 -0.194 0.366 c -0.31 0.452 -0.451 0.495 -0.595 0.489 c -0.675 0.488 -0.755 0.476 -0.831 0.452 c -0.918 0.424 -0.998 0.375 -1.062 0.311 c -1.142 0.229 -1.202 0.131 -1.24 0.024 c -1.29 -0.132 -1.312 -0.296 -1.304 -0.459 c -1.304 -0.569 -1.292 -0.677 -1.267 -0.784 c -1.244 -0.885 -1.202 -0.983 -1.145 -1.07 c -1.09 -1.154 -1.016 -1.224 -0.93 -1.275 c -0.833 -1.33 -0.722 -1.356 -0.611 -1.352 c -0.457 -1.357 -0.307 -1.301 -0.194 -1.195 c -0.078 -1.077 -0.005 -0.922 0.011 -0.757 c 0.587 -0.757 l 0.556 -1.055 0.419 -1.332 0.202 -1.538 c -0.022 -1.721 -0.306 -1.815 -0.595 -1.803 c -0.777 -1.806 -0.958 -1.771 -1.126 -1.7 c -1.293 -1.642 -1.445 -1.547 -1.57 -1.421 c -1.68 -1.297 -1.763 -1.151 -1.814 -0.993 c -1.87 -0.822 -1.898 -0.643 -1.896 -0.462 c -1.898 -0.276 -1.871 -0.091 -1.817 0.087 c -1.766 0.252 -1.682 0.405 -1.57 0.537 c -1.459 0.664 -1.323 0.766 -1.168 0.834 c -0.991 0.914 -0.798 0.955 -0.603 0.954 c -0.457 0.954 -0.311 0.935 -0.17 0.895 c -0.039 0.858 0.084 0.799 0.194 0.72 c 0.302 0.643 0.393 0.543 0.459 0.428 c 0.531 0.298 0.572 0.155 0.582 0.008 c 0 0.008 l 0 0 l f Q q 1 0 0 1 423.2177 733.5723 cm 0 0 m 0.577 0 l 0.577 -2.048 l 1.615 -0.985 l 2.322 -0.985 l 1.323 -1.944 l 2.417 -3.604 l 1.716 -3.604 l 0.919 -2.337 l 0.577 -2.669 l 0.577 -3.604 l 0 -3.604 l h f Q q 1 0 0 1 427.0585 732.5762 cm 0 0 m 0.436 0 l 0.436 0.218 l 0.429 0.352 0.448 0.486 0.488 0.614 c 0.521 0.705 0.577 0.786 0.651 0.85 c 0.717 0.905 0.795 0.943 0.879 0.961 c 0.966 0.979 1.056 0.988 1.145 0.988 c 1.28 0.993 1.416 0.981 1.548 0.954 c 1.548 0.505 l 1.509 0.516 1.469 0.523 1.429 0.528 c 1.379 0.532 1.33 0.532 1.28 0.528 c 1.209 0.53 1.14 0.511 1.081 0.473 c 1.019 0.419 0.987 0.337 0.999 0.255 c 0.999 -0.011 l 1.498 -0.011 l 1.498 -0.441 l 1.009 -0.441 l 1.009 -2.622 l 0.436 -2.622 l 0.436 -0.428 l 0.005 -0.428 l 0.005 0 l 0 0 l f Q q 1 0 0 1 430.1 729.8965 cm 0 0 m -0.191 -0.003 -0.381 0.032 -0.559 0.104 c -0.715 0.167 -0.856 0.264 -0.972 0.388 c -1.091 0.512 -1.181 0.659 -1.238 0.82 c -1.356 1.18 -1.356 1.567 -1.238 1.925 c -1.181 2.087 -1.091 2.234 -0.972 2.358 c -0.856 2.481 -0.715 2.578 -0.559 2.643 c -0.199 2.78 0.198 2.78 0.558 2.643 c 0.714 2.578 0.855 2.481 0.972 2.358 c 1.09 2.234 1.181 2.087 1.237 1.925 c 1.355 1.567 1.355 1.18 1.237 0.82 c 1.181 0.659 1.09 0.512 0.972 0.388 c 0.855 0.266 0.713 0.169 0.558 0.106 c 0.38 0.034 0.191 -0.002 0 0 c 0 0.454 m 0.115 0.451 0.23 0.479 0.332 0.534 c 0.424 0.586 0.502 0.659 0.562 0.746 c 0.624 0.836 0.669 0.936 0.695 1.041 c 0.752 1.26 0.752 1.491 0.695 1.71 c 0.669 1.816 0.625 1.916 0.562 2.005 c 0.502 2.091 0.423 2.163 0.332 2.215 c 0.123 2.323 -0.126 2.323 -0.335 2.215 c -0.427 2.163 -0.505 2.091 -0.566 2.005 c -0.628 1.916 -0.673 1.816 -0.699 1.71 c -0.756 1.491 -0.756 1.26 -0.699 1.041 c -0.672 0.936 -0.627 0.836 -0.566 0.746 c -0.506 0.659 -0.427 0.586 -0.335 0.534 c -0.232 0.478 -0.117 0.451 0 0.454 c f Q q 1 0 0 1 431.8979 732.5762 cm 0 0 m 0.531 0 l 0.531 -0.505 l 0.55 -0.43 0.583 -0.359 0.629 -0.297 c 0.681 -0.229 0.74 -0.167 0.807 -0.114 c 0.877 -0.059 0.956 -0.014 1.039 0.019 c 1.123 0.053 1.213 0.07 1.304 0.069 c 1.52 0.069 l 1.52 -0.486 l 1.395 -0.467 l 1.269 -0.467 l 1.178 -0.468 1.087 -0.488 1.004 -0.526 c 0.917 -0.565 0.839 -0.625 0.778 -0.699 c 0.716 -0.783 0.669 -0.878 0.643 -0.98 c 0.604 -1.104 0.584 -1.233 0.586 -1.362 c 0.586 -2.603 l 0.01 -2.603 l 0.01 0 l 0 0 l f Q q 1 0 0 1 437.3666 729.9683 cm 0 0 m -0.577 0 l -0.577 0.364 l -0.649 0.23 -0.759 0.121 -0.893 0.047 c -1.022 -0.029 -1.169 -0.07 -1.32 -0.072 c -1.595 -0.095 -1.866 0.002 -2.064 0.194 c -2.234 0.413 -2.316 0.687 -2.295 0.964 c -2.295 2.608 l -1.719 2.608 l -1.719 1.014 l -1.735 0.843 -1.689 0.67 -1.588 0.531 c -1.492 0.433 -1.357 0.382 -1.219 0.39 c -1.116 0.387 -1.012 0.406 -0.917 0.446 c -0.84 0.479 -0.772 0.531 -0.72 0.595 c -0.667 0.661 -0.63 0.738 -0.611 0.82 c -0.588 0.911 -0.577 1.003 -0.577 1.097 c -0.577 2.611 l 0 2.611 l 0 0 l f Q q 1 0 0 1 437.9877 732.5762 cm 0 0 m 0.545 0 l 0.545 -0.353 l 0.617 -0.209 0.736 -0.094 0.882 -0.026 c 1.03 0.04 1.19 0.073 1.352 0.072 c 1.535 0.075 1.717 0.038 1.883 -0.037 c 2.031 -0.106 2.161 -0.208 2.263 -0.334 c 2.366 -0.465 2.442 -0.615 2.489 -0.775 c 2.54 -0.948 2.566 -1.127 2.566 -1.307 c 2.566 -1.479 2.542 -1.651 2.497 -1.817 c 2.455 -1.973 2.385 -2.121 2.29 -2.252 c 2.099 -2.522 1.789 -2.682 1.458 -2.68 c 1.369 -2.681 1.28 -2.674 1.193 -2.659 c 1.11 -2.644 1.028 -2.618 0.951 -2.584 c 0.875 -2.552 0.802 -2.509 0.736 -2.457 c 0.671 -2.406 0.615 -2.343 0.571 -2.273 c 0.571 -3.575 l -0.005 -3.575 l -0.005 0 l 0 0 l 2.008 -1.307 m 2.008 -1.191 1.993 -1.076 1.963 -0.964 c 1.936 -0.859 1.89 -0.759 1.828 -0.669 c 1.768 -0.584 1.69 -0.514 1.599 -0.462 c 1.503 -0.409 1.395 -0.382 1.286 -0.385 c 1.072 -0.372 0.867 -0.467 0.738 -0.638 c 0.607 -0.836 0.543 -1.072 0.555 -1.31 c 0.554 -1.433 0.57 -1.557 0.603 -1.676 c 0.631 -1.781 0.68 -1.879 0.747 -1.965 c 0.809 -2.044 0.886 -2.109 0.975 -2.157 c 1.071 -2.206 1.178 -2.23 1.286 -2.229 c 1.401 -2.232 1.517 -2.205 1.618 -2.148 c 1.708 -2.096 1.785 -2.025 1.843 -1.939 c 1.903 -1.85 1.945 -1.751 1.968 -1.646 c 1.995 -1.535 2.008 -1.421 2.008 -1.307 c f Q q 1 0 0 1 443.5127 729.9683 cm 0 0 m -0.545 0 l -0.545 0.353 l -0.616 0.211 -0.734 0.099 -0.879 0.034 c -1.027 -0.031 -1.187 -0.065 -1.349 -0.064 c -1.532 -0.067 -1.714 -0.03 -1.88 0.045 c -2.028 0.113 -2.158 0.214 -2.26 0.34 c -2.364 0.47 -2.441 0.62 -2.486 0.781 c -2.538 0.958 -2.564 1.143 -2.563 1.328 c -2.568 1.536 -2.536 1.742 -2.468 1.938 c -2.41 2.097 -2.319 2.242 -2.202 2.364 c -2.101 2.471 -1.977 2.555 -1.838 2.608 c -1.705 2.659 -1.563 2.685 -1.421 2.685 c -1.338 2.685 -1.256 2.678 -1.174 2.664 c -1.091 2.648 -1.01 2.624 -0.932 2.589 c -0.855 2.556 -0.783 2.514 -0.717 2.462 c -0.652 2.411 -0.597 2.349 -0.553 2.279 c -0.553 3.606 l 0.024 3.606 l 0.024 0 l 0 0 l -2.008 1.277 m -2.009 1.166 -1.994 1.056 -1.965 0.948 c -1.939 0.845 -1.896 0.748 -1.835 0.661 c -1.777 0.578 -1.699 0.508 -1.61 0.459 c -1.404 0.355 -1.162 0.355 -0.956 0.459 c -0.866 0.512 -0.789 0.585 -0.73 0.671 c -0.671 0.762 -0.626 0.862 -0.6 0.966 c -0.572 1.076 -0.558 1.188 -0.558 1.301 c -0.543 1.542 -0.612 1.781 -0.751 1.979 c -0.88 2.14 -1.078 2.229 -1.283 2.22 c -1.402 2.224 -1.52 2.196 -1.623 2.138 c -1.714 2.083 -1.793 2.009 -1.852 1.92 c -1.911 1.828 -1.954 1.725 -1.977 1.617 c -1.999 1.505 -2.01 1.392 -2.008 1.277 c f Q q 1 0 0 1 446.3252 730.5499 cm 0 0 m -0.004 -0.052 0.005 -0.104 0.026 -0.151 c 0.052 -0.185 0.094 -0.202 0.136 -0.197 c 0.197 -0.197 l 0.223 -0.2 0.25 -0.2 0.276 -0.197 c 0.276 -0.595 l 0.199 -0.619 l 0.101 -0.64 l 0 -0.656 l -0.085 -0.656 l -0.187 -0.66 -0.288 -0.635 -0.377 -0.584 c -0.461 -0.528 -0.516 -0.437 -0.528 -0.337 c -0.648 -0.451 -0.792 -0.534 -0.951 -0.579 c -1.106 -0.628 -1.269 -0.654 -1.432 -0.656 c -1.546 -0.657 -1.659 -0.641 -1.769 -0.608 c -1.872 -0.579 -1.967 -0.531 -2.053 -0.468 c -2.136 -0.405 -2.203 -0.324 -2.25 -0.231 c -2.3 -0.127 -2.326 -0.012 -2.324 0.104 c -2.33 0.24 -2.299 0.375 -2.236 0.497 c -2.181 0.594 -2.101 0.675 -2.005 0.733 c -1.905 0.791 -1.795 0.833 -1.681 0.855 c -1.562 0.88 -1.442 0.899 -1.32 0.914 c -1.222 0.933 -1.123 0.947 -1.022 0.956 c -0.938 0.963 -0.855 0.977 -0.773 0.999 c -0.708 1.014 -0.649 1.046 -0.6 1.092 c -0.556 1.144 -0.533 1.211 -0.536 1.28 c -0.534 1.344 -0.553 1.408 -0.59 1.46 c -0.624 1.507 -0.668 1.544 -0.72 1.569 c -0.775 1.596 -0.834 1.613 -0.895 1.62 c -0.955 1.624 -1.016 1.624 -1.076 1.62 c -1.215 1.625 -1.354 1.591 -1.474 1.519 c -1.581 1.45 -1.647 1.333 -1.652 1.206 c -2.231 1.206 l -2.227 1.354 -2.185 1.498 -2.108 1.625 c -2.041 1.733 -1.951 1.824 -1.843 1.891 c -1.729 1.96 -1.603 2.007 -1.472 2.032 c -1.329 2.072 -1.183 2.098 -1.036 2.109 c -0.908 2.109 -0.781 2.096 -0.656 2.069 c -0.538 2.044 -0.425 2 -0.321 1.939 c -0.225 1.88 -0.143 1.8 -0.083 1.705 c -0.02 1.599 0.012 1.478 0.008 1.354 c 0.008 0.013 l 0 0 l -0.576 0.728 m -0.674 0.667 -0.785 0.631 -0.9 0.624 c -1.028 0.612 -1.155 0.594 -1.283 0.571 c -1.343 0.561 -1.402 0.547 -1.46 0.528 c -1.515 0.511 -1.566 0.485 -1.612 0.451 c -1.657 0.419 -1.692 0.376 -1.716 0.327 c -1.742 0.267 -1.755 0.203 -1.753 0.138 c -1.755 0.079 -1.735 0.021 -1.697 -0.024 c -1.661 -0.067 -1.615 -0.103 -1.564 -0.127 c -1.509 -0.154 -1.451 -0.171 -1.392 -0.181 c -1.335 -0.19 -1.278 -0.196 -1.222 -0.197 c -1.152 -0.196 -1.083 -0.188 -1.015 -0.173 c -0.94 -0.156 -0.87 -0.127 -0.805 -0.088 c -0.74 -0.048 -0.684 0.004 -0.64 0.066 c -0.594 0.134 -0.571 0.215 -0.574 0.297 c -0.574 0.725 l h f Q q 1 0 0 1 446.6836 732.5762 cm 0 0 m 0.434 0 l 0.434 0.784 l 0.996 0.784 l 0.996 0 l 1.527 0 l 1.527 -0.43 l 0.996 -0.43 l 0.996 -1.822 l 0.993 -1.874 0.993 -1.927 0.996 -1.979 c 1 -2.018 1.011 -2.056 1.031 -2.09 c 1.05 -2.122 1.079 -2.146 1.113 -2.159 c 1.162 -2.177 1.213 -2.185 1.265 -2.183 c 1.387 -2.183 l 1.428 -2.181 1.469 -2.175 1.509 -2.165 c 1.509 -2.608 l 1.323 -2.629 l 1.261 -2.633 1.199 -2.633 1.137 -2.629 c 1.013 -2.633 0.89 -2.619 0.771 -2.587 c 0.688 -2.564 0.613 -2.52 0.553 -2.459 c 0.499 -2.4 0.462 -2.328 0.446 -2.25 c 0.427 -2.155 0.416 -2.059 0.415 -1.963 c 0.415 -0.428 l -0.019 -0.428 l -0.019 0 l 0 0 l f Q q 1 0 0 1 449.0742 731.1235 cm 0 0 m 0 -0.099 0.014 -0.198 0.042 -0.292 c 0.068 -0.382 0.112 -0.466 0.17 -0.54 c 0.229 -0.611 0.303 -0.669 0.388 -0.709 c 0.486 -0.754 0.593 -0.776 0.701 -0.773 c 0.845 -0.78 0.987 -0.742 1.107 -0.664 c 1.216 -0.582 1.296 -0.468 1.336 -0.337 c 1.88 -0.337 l 1.827 -0.603 1.674 -0.838 1.456 -0.996 c 1.349 -1.073 1.231 -1.131 1.105 -1.169 c 0.973 -1.208 0.836 -1.228 0.699 -1.227 c 0.512 -1.23 0.327 -1.196 0.154 -1.126 c 0.003 -1.066 -0.133 -0.973 -0.244 -0.855 c -0.356 -0.73 -0.44 -0.583 -0.491 -0.422 c -0.548 -0.243 -0.576 -0.056 -0.574 0.133 c -0.575 0.313 -0.546 0.493 -0.486 0.664 c -0.426 0.826 -0.336 0.974 -0.221 1.102 c 0.002 1.374 0.334 1.532 0.685 1.535 c 0.877 1.539 1.067 1.495 1.238 1.408 c 1.396 1.326 1.535 1.209 1.644 1.067 c 1.753 0.922 1.833 0.757 1.878 0.582 c 1.927 0.396 1.939 0.203 1.915 0.013 c -0.002 0.013 l 0 0 l 1.341 0.377 m 1.335 0.468 1.315 0.557 1.283 0.643 c 1.253 0.724 1.209 0.798 1.153 0.863 c 1.096 0.926 1.027 0.978 0.951 1.014 c 0.868 1.054 0.777 1.074 0.685 1.073 c 0.594 1.073 0.504 1.055 0.419 1.02 c 0.339 0.986 0.267 0.937 0.207 0.874 c 0.147 0.81 0.099 0.735 0.066 0.653 c 0.031 0.569 0.011 0.479 0.008 0.388 c 1.349 0.388 l h f Q q 1 0 0 1 451.8657 730.7994 cm 0 0 m 0.002 -0.142 0.073 -0.274 0.191 -0.353 c 0.312 -0.423 0.45 -0.458 0.59 -0.454 c 0.651 -0.458 0.711 -0.458 0.773 -0.454 c 0.839 -0.447 0.904 -0.43 0.967 -0.406 c 1.024 -0.385 1.075 -0.349 1.116 -0.303 c 1.155 -0.252 1.174 -0.189 1.168 -0.125 c 1.166 -0.057 1.138 0.008 1.089 0.056 c 1.033 0.107 0.967 0.146 0.895 0.17 c 0.809 0.201 0.72 0.226 0.629 0.245 c 0.329 0.33 l 0.224 0.352 0.121 0.38 0.019 0.415 c -0.076 0.446 -0.166 0.491 -0.247 0.55 c -0.327 0.608 -0.391 0.683 -0.436 0.771 c -0.486 0.873 -0.511 0.986 -0.507 1.1 c -0.512 1.226 -0.475 1.351 -0.404 1.456 c -0.333 1.551 -0.243 1.63 -0.138 1.687 c -0.028 1.747 0.092 1.788 0.215 1.809 c 0.337 1.832 0.462 1.843 0.587 1.843 c 0.716 1.844 0.845 1.83 0.972 1.801 c 1.09 1.774 1.202 1.727 1.304 1.663 c 1.404 1.598 1.488 1.513 1.551 1.413 c 1.621 1.3 1.663 1.173 1.676 1.041 c 1.076 1.041 l 1.059 1.155 0.989 1.253 0.887 1.307 c 0.78 1.355 0.665 1.38 0.547 1.378 c 0.5 1.381 0.452 1.381 0.403 1.378 c 0.35 1.373 0.298 1.36 0.247 1.341 c 0.2 1.325 0.157 1.297 0.122 1.262 c 0.087 1.224 0.069 1.174 0.071 1.124 c 0.069 1.058 0.096 0.995 0.146 0.951 c 0.202 0.903 0.267 0.866 0.337 0.842 c 0.424 0.811 0.512 0.786 0.603 0.768 c 0.917 0.701 l 1.021 0.678 1.124 0.65 1.224 0.616 c 1.319 0.584 1.409 0.539 1.49 0.481 c 1.662 0.359 1.762 0.16 1.755 -0.05 c 1.76 -0.189 1.723 -0.326 1.649 -0.443 c 1.582 -0.551 1.491 -0.642 1.384 -0.709 c 1.267 -0.778 1.14 -0.827 1.007 -0.855 c 0.873 -0.885 0.735 -0.9 0.598 -0.9 c 0.443 -0.902 0.29 -0.883 0.141 -0.845 c 0.01 -0.812 -0.114 -0.753 -0.223 -0.674 c -0.324 -0.601 -0.407 -0.504 -0.465 -0.393 c -0.527 -0.269 -0.559 -0.131 -0.558 0.008 c 0.019 0.008 l 0 0 l f Q 0.146 0.941 0.992 0.044 k q 1 0 0 1 401.2527 729.3892 cm 0 0 m 3.612 2.406 l 3.612 5.296 l 0 5.296 l h f Q 0 0.889 0.676 0 k q 1 0 0 1 404.865 729.3892 cm 0 0 m -3.612 2.406 l -3.612 5.296 l 0 5.296 l h f Q 0.694 0.076 0.209 0 k q 1 0 0 1 403.0589 735.3145 cm 0 0 m -2.2 0 -3.984 -1.784 -3.984 -3.984 c -3.984 -6.184 -2.2 -7.968 0 -7.968 c 2.2 -7.968 3.984 -6.184 3.984 -3.984 c 3.984 -1.784 2.2 0 0 0 c 0 -6.993 m -1.662 -6.993 -3.009 -5.646 -3.009 -3.984 c -3.009 -2.322 -1.662 -0.975 0 -0.975 c 1.662 -0.975 3.009 -2.322 3.009 -3.984 c 3.009 -5.646 1.662 -6.993 0 -6.993 c f Q 0 0.235 0.86 0 k q 1 0 0 1 405.2601 729.2803 cm 0 0 m -1.118 -1.208 -3.015 -1.281 -4.237 -0.159 c -5.159 0.688 -5.459 2.005 -4.999 3.156 c -5.833 3.687 l -6.736 1.681 -5.843 -0.679 -3.836 -1.582 c -2.218 -2.311 -0.312 -1.881 0.836 -0.528 c 0 0 l f Q 0 0 0 0.6 k q 1 0 0 1 397.4813 736.8087 cm 0 0 m -0.238 0 -0.432 -0.193 -0.432 -0.432 c -0.432 -10.524 l -0.432 -10.763 -0.238 -10.956 0 -10.956 c 57.901 -10.956 l 58.139 -10.956 58.333 -10.763 58.333 -10.524 c 58.333 -0.432 l 58.333 -0.193 58.139 0 57.901 0 c h 57.901 -11.155 m 0 -11.155 l -0.348 -11.155 -0.631 -10.872 -0.631 -10.524 c -0.631 -0.432 l -0.631 -0.084 -0.348 0.199 0 0.199 c 57.901 0.199 l 58.249 0.199 58.532 -0.084 58.532 -0.432 c 58.532 -10.524 l 58.532 -10.872 58.249 -11.155 57.901 -11.155 c f Q EMC Q endstream endobj 1718 0 obj <> endobj 1723 0 obj <>stream Adobe Illustrator CS6 (Windows) 2021-04-12T11:45:36+05:00 2021-06-02T10:28:09+05:00 2021-06-02T10:28:09+05:00 1 False False 20.868494 3.999928 Millimeters Cyan Magenta Yellow Black Default Swatch Group 0 C=0 M=24 Y=86 K=0 PROCESS 100.000000 CMYK 0.000000 23.504999 86.022697 0.000000 C=69 M=8 Y=21 K=0 PROCESS 100.000000 CMYK 69.369003 7.635600 20.892700 0.000000 C=0 M=89 Y=68 K=0 PROCESS 100.000000 CMYK 0.000000 88.946404 67.623398 0.000000 C=15 M=94 Y=99 K=4 PROCESS 100.000000 CMYK 14.578501 94.070297 99.160698 4.416000 C=0 M=0 Y=0 K=84 PROCESS 100.000000 CMYK 0.000000 0.000000 0.000000 84.000000 C=0 M=0 Y=0 K=35 PROCESS 100.000000 CMYK 0.000000 0.000000 0.000000 35.000000 C=0 M=0 Y=0 K=60 PROCESS 100.000000 CMYK 0.000000 0.000000 0.000000 60.000004 Document application/pdf proof:pdf xmp.did:804244B35A9BEB118A6FC3C256996E2F uuid:08e30110-bdb7-4606-97ca-63fb62cbcecc uuid:21079f76-f6d7-4329-b725-f2fb35af5114 uuid:722f8893-0b3c-4402-87fb-c713f1fa0e26 uuid:21079f76-f6d7-4329-b725-f2fb35af5114 uuid:21079f76-f6d7-4329-b725-f2fb35af5114 proof:pdf saved xmp.iid:804244B35A9BEB118A6FC3C256996E2F 2021-04-12T11:45:42+05:00 Adobe Illustrator CS6 (Windows) / endstream endobj 1722 0 obj <>/Border[0 0 0]/H/N/Rect[394.85 739.008 458.005 723.67]/Subtype/Link/Type/Annot>> endobj 1724 0 obj <> endobj 1714 0 obj [1725 0 R 1726 0 R 1727 0 R 1728 0 R 1729 0 R 1730 0 R 1731 0 R 1732 0 R 1733 0 R 1734 0 R 1735 0 R 1736 0 R 1737 0 R 1738 0 R 1739 0 R 1740 0 R 1741 0 R 1742 0 R 1743 0 R 1744 0 R 1745 0 R 1746 0 R 1747 0 R 1748 0 R 1749 0 R 1750 0 R 1751 0 R 1752 0 R 1753 0 R 1754 0 R 1755 0 R 1756 0 R 1757 0 R 1758 0 R 1759 0 R 1760 0 R 1761 0 R 1762 0 R 1763 0 R 1764 0 R] endobj 1715 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\034\002\025\202\001\025)21(\222 \006)-10(\026)11(\016\221\016\001\220 \221\025\r\002\016\217)-20.9(\201\016\001\220\203 \026)11(\013\222\025\r\025\202)10.1(\025 \201\001\013 \r\022\007\016\017\016\001\220\220 )]TJ 0 -1 TD [(\221\025\006)-10(\026)-31(\026\002\013\r\024\013\026\220\017\016\006\n)10(\025\202)10(\025 \013\001\013\007\216\001\025\202)10(\025 \001\016\201\016\002\217\013\001\220\205)]TJ 42.45 1 Td [(Pr)20(ognoses of injur)-30.9(y scale in sur)31(gical tr)31(eatment )]TJ 4.112 -1 Td [(of post-tr)21(aumatic anal incontinence)]TJ /T1_1 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 42.5896 724.8299 Tm [(\r\031\024\034\033)48(\026)45(\024)-10(\223\033)48(\026)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf 0 Tc 8 0 0 8 42.5197 711.9952 Tm (1.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(P)30(er)-32(gial)-30.9(io)17(t)-32(is)]TJ /Span<>> BDC ( )Tj EMC [(V, Bell)30(os)]TJ /Span<>> BDC ( )Tj EMC [(I, )0.5(F)19.9(anak)-15.9(i)]TJ /Span<>> BDC ( )Tj EMC [(M, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. R)-24(isk )0.5(f)16(a)-17(c)-16(t)17(or)-10(s for )0.5(sever)-24(e per)-36.9(i)]TJ 0 Tw (-)Tj 0.093 Tw -1.296 -1.25 Td [(neal tr)-33(auma dur)-36.9(ing childbir)-22(t)-12.9(h: An upd)42(a)15(ted me)-12(t)15(a-anal)35(y)-13(sis. )]TJ /T1_3 1 Tf 0 Tw (European )Tj 0.007 Tc 0.349 Tw 0 -1.25 TD [(Jour)-13.6(nal of Obstetr)-36.6(ics and Gynecology and R)21.3(ep)46.4(roductiv)13.3(e Biology.)]TJ /T1_2 1 Tf 0 Tc 0 Tw 27.638 0 Td ( )Tj 0.023 Tw -27.638 -1.25 Td [(2020;247:94\226100. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw [(10.1016/j.ejo)-16(gr)-23.9(b.2020.02.025)]TJ 0 0 0 1 k /GS1 gs 0.013 Tc 0.466 Tw T* (2.)Tj /Span<>> BDC ( )Tj EMC 1.334 0 Td [(Bl)30.3(omquist)]TJ /Span<>> BDC ( )Tj EMC (JL, Mu\361oz)Tj /Span<>> BDC ( )Tj EMC [(A, Car)-23.7(r)-31.6(oll)]TJ /Span<>> BDC ( )Tj EMC [(M, e)-11.6(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Asso)-15.7(c)-23.6(ia)15.4(t)-31.7(ion of)13( )]TJ 0 Tc 0.193 Tw -1.334 -1.25 Td [(Del)-31(i)-16(ver)-23.9(y M)-23.9(ode W)-16(i)-23.9(t)-13(h P)30.1(el)30(v)-16(ic Fl)30(o)-16(or Disor)-23.9(der)-10(s Af)-28(ter Childbir)-22(t)-13(h. )]TJ /T1_3 1 Tf 0 Tw [(J)30(AMA. )]TJ /T1_2 1 Tf 0.023 Tw T* [(2018;320:2438\2262447. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw [(10.1001/J)15(AMA.2018.18315)]TJ 0 0 0 1 k /GS1 gs -0.031 Tw T* (3.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(KM G, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Can we im)10(p)25(r)-32(ove on t)-13(he dia)-16.9(gnosis of t)-13(hir)-24(d degr)-23.9(ee tear)-10(s? )]TJ /T1_3 1 Tf 0.221 Tw -1.296 -1.25 Td [(Eur J Obstet Gynecol R)21(ep)46(rod Biol. )]TJ /T1_2 1 Tf [(2002;101:19\22621. d)-15.9(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1016/)Tj T* (S0301-2115\(01\)00495-X)Tj 0 0 0 1 k /GS1 gs 0.289 Tw T* (4.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(F)20(ar)-24(r)-33(ar)]TJ /Span<>> BDC ( )Tj EMC [(D, T)60(uf)-56(fnell)]TJ /Span<>> BDC ( )Tj EMC [(DJ, R)-10(ama)-17(ge)]TJ /Span<>> BDC ( )Tj EMC [(C. Inter)-31.9(vent)-32(ions for w)-14(omen in )]TJ 0.061 Tw -1.296 -1.25 Td [(subsequent p)25(r)-23.9(egnanc)-24(ies foll)30(o)-13.9(wing obste)-12(tr)-37(ic anal sphinc)-15.9(ter injur)-24(y t)17(o )]TJ 0.113 Tw T* [(r)-24(educe )0.5(t)-13(he r)-37(isk )0.5(of r)-24(ecur)-23.9(r)-24(ent injur)-23.9(y and )0.5(asso)-16(c)-24(ia)15(ted har)-15.9(ms. )]TJ /T1_3 1 Tf 0 Tw (Cochrane )Tj 0.009 Tw T* [(Database of Systematic R)21.1(evie)10(ws.)]TJ /T1_2 1 Tf [( 2014;2014. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1002/14651858.)Tj T* (CD010374.pub2)Tj 0 0 0 1 k /GS1 gs 0.005 Tc 0.349 Tw T* (5.)Tj /Span<>> BDC ( )Tj EMC 1.31 0 Td [(P)40.2(andi)-23.8(t)]TJ /Span<>> BDC ( )Tj EMC [(B. Mana)-16.8(gement of T)47.2(hir)-23.7(d and F)10.2(our)-21.8(t)-12.8(h-degr)-23.7(ee P)30.2(er)-36.8(ineal)5( )]TJ 0 Tc 0 Tw -1.31 -1.25 Td [(T)40(ear)-10(s. )]TJ /T1_3 1 Tf 0.036 Tw 2.63 0 Td [(Smar)-39.9(t Obstet Gynecol Handb.)]TJ /T1_2 1 Tf [( 2018;101\226101. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.5005/jp/)Tj -2.63 -1.25 Td [(bo)-16(ok)-10(s/13082_12)]TJ 0 0 0 1 k /GS1 gs 0.169 Tw T* (6.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Sul)56(t)15(an)]TJ /Span<>> BDC ( )Tj EMC [(A)58.1(H, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Anal end)-16(osono)-16(gr)-33(aphy and cor)-24(r)-24(el)-16(a)15(t)-31.9(ion wi)-24(t)-13(h in )]TJ -0.048 Tw -1.296 -1.25 Td [(v)-16(i)-24(tr)-31.9(o and in v)-15.9(i)-16(vo ana)15(t)17(omy. )]TJ /T1_3 1 Tf (Br J Surg.)Tj /T1_2 1 Tf [( 1993;80:508\226511. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1002/)Tj T* (bjs.1800800435)Tj 0 0 0 1 k /GS1 gs 0.052 Tw T* (7.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(T)47(hak)-17(ar)]TJ /Span<>> BDC ( )Tj EMC [(R, Sul)56(t)15(an)]TJ /Span<>> BDC ( )Tj EMC [(A)58(H. Anal end)-16(osono)-16(gr)-33(aphy and i)-24(ts r)-31.9(ole in assess)]TJ 0 Tw (-)Tj 0.285 Tw -1.296 -1.25 Td [(ing t)-13(he incont)-32(inent p)32(a)15(t)-32(ient. )]TJ /T1_3 1 Tf [(Best Practice and R)21(esearch: Clinical )]TJ 0.149 Tw T* [(Obstetr)-36.9(ics and Gynaecology.)]TJ /T1_2 1 Tf [( 2004;18:157\226173. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1016/j.bpo)Tj (-)Tj T* [(bg)16(yn.2003.09.007)]TJ 0 0 0 1 k /GS1 gs -0.024 Tw 29.055 30 Td (8.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (Oom)Tj /Span<>> BDC ( )Tj EMC 1.985 0 Td [(DMJ, )0.6(W)21.9(est)]TJ /Span<>> BDC ( )Tj EMC 4.166 0 Td [(RL, )0.6(S)-24(chouten)]TJ /Span<>> BDC ( )Tj EMC 5.372 0 Td [(WR, )0.6(e)-12(t)]TJ /Span<>> BDC ( )Tj EMC 2.664 0 Td [(al. )0.6(De)-12(tec)-16(t)-32(ion )0.6(of )0.5(anal )0.6(sphinc)-16(ter )]TJ 0.048 Tw -15.483 -1.25 Td [(defec)-16(ts in female p)32(a)15(t)-32(ients wi)-23.9(t)-13(h fecal incont)-32(inence: A com)10(p)32(ar)-37(ison of )]TJ 0.02 Tw T* [(3-dimensional tr)-32.9(ansper)-37(ineal ul)56.1(tr)-33(asound and 2-dimensional end)-16(oanal )]TJ 0.004 Tc -0.004 Tw T* [(ul)55.9(tr)-33.1(asound. )]TJ /T1_3 1 Tf 0.35 Tw 5.238 0 Td [(Dis Colon R)21(ectum.)]TJ /T1_2 1 Tf ( 2012;)Tj /T1_3 1 Tf 0 Tc 0 Tw (5)Tj /T1_2 1 Tf 0.004 Tc 0.35 Tw 11.163 0 Td [(5:646\226652. )0.5(d)-16.1(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs -0.004 Tw 7.47 0 Td (10.1097/)Tj 0 Tc 0 Tw -23.87 -1.25 Td (DCR.0b013e318251dca1)Tj 0 0 0 1 k /GS1 gs 0.107 Tw T* (9.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(A)-14(br)-33(ams)]TJ /Span<>> BDC ( )Tj EMC 3.328 0 Td [(P, )0.5(Ander)-9.9(sson )0.5(K-E, )0.6(Apost)17(ol)-31(idis)]TJ /Span<>> BDC ( )Tj EMC 12.271 0 Td [(A, )0.5(e)-12(t)]TJ /Span<>> BDC ( )Tj EMC 2.249 0 Td [(al. )0.6(6t)-13(h )0.5(Inter)-14.9(na)15(t)-32(ional )]TJ 0.022 Tc 0.809 Tw -19.144 -1.25 Td [(Consul)55.6(t)14.6(a)14.6(t)-32.4(ion on Incont)-32.4(inence. R)12.6(ecommend)41.6(a)14.6(t)-32.4(ions of t)-13.4(he)22( )]TJ 0 Tc 0.228 Tw T* [(Inter)-15(na)15.1(t)-32(ional S)-23.9(c)-24(ient)-32(if)-28(ic Commi)-24(t)-30(tee: EV)37(AL)50.1(U)17.9(A)15.1(TION A)51.1(ND TREA)15(TMENT )]TJ 0.163 Tw T* [(OF URIN)13(AR)-14(Y INC)13(ONTINENCE, PEL)65(VIC ORGA)51.1(N PROL)-34.9(APSE A)51(ND F)24(AEC)20(AL )]TJ 0.012 Tc -0.012 Tw T* [(IN)0.5(C)13.4(ON)0.5(TIN)0.5(ENC)0.5(E.)0.5( )]TJ /T1_3 1 Tf 0.428 Tw 7.127 0 Td [(N)18.4(e)0.5(uro)0.5(ur)0.5(ol U)22.4(ro)0.5(dyn)]TJ /T1_2 1 Tf 7.461 0 Td [(. 2)0.5(018)0.5( Sep)0.5(;37)0.5(\(7\))0.5(:22)0.5(71\226)0.5(2272)0.5(.)12( )]TJ 0 Tc 0 Tw -14.588 -1.25 Td [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td [(10.1002/N)13(A)17(U.23551)]TJ 0 0 0 1 k /GS1 gs 0.132 Tw -1.847 -1.25 Td (10.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Hull)Tj /Span<>> BDC ( )Tj EMC (TL, Milsom)Tj /Span<>> BDC ( )Tj EMC [(JW. P)30(el)30(v)-16(ic fl)30(o)-16(or disor)-23.9(der)-10(s. )]TJ /T1_3 1 Tf [(Surg Clin N)17(or)-40(th Am)]TJ /T1_2 1 Tf 0 Tw (. )Tj 0.023 Tw -1.796 -1.25 Td [(1994 Dec;74\(6\):1399\226413. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1016/S0039-6109\(16\)46489-3)Tj 0 0 0 1 k /GS1 gs 0.216 Tw T* (11.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Cl)-16(av)-15.9(ien)]TJ /Span<>> BDC ( )Tj EMC [(P, )0.6(Sanabr)-37(ia)]TJ /Span<>> BDC ( )Tj EMC 8.473 0 Td [(J, )0.5(S)15(tr)-33(asber)-31.9(g)]TJ /Span<>> BDC ( )Tj EMC [(S. )0.5(P)35(r)-32(oposed )0.5(cl)-15.9(assif)-28(ica)15(t)-32(ion )0.5(of )]TJ -0.014 Tw -10.269 -1.25 Td [(com)10(pl)-31(ica)15.1(t)-32(ion of sur)-31.9(ger)-24(y wi)-24(t)-13(h e)-18(x)-10.9(am)10(ples of ut)-32(il)-31(i)-24(t)-9.9(y in cholecy)-12.9(stec)-16(t)17(omy. )]TJ /T1_3 1 Tf 0 Tw T* [(Surg)12(er)-43(y)]TJ /T1_2 1 Tf 0.023 Tw (. 1992;111:518\226526. PMID: 1598671.)Tj 0.029 Tw T* (12.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Dind)-16(o)]TJ /Span<>> BDC ( )Tj EMC 2.632 0 Td [(D, Demar)-21.9(t)-32(ines N )0.5(and Cl)-16(av)-15.9(ien)]TJ /Span<>> BDC ( )Tj EMC [(P)25(A. )0.5(Cl)-16(assif)-28(ica)15(t)-31.9(ion of )0.5(sur)-32(gical )]TJ 0.102 Tw -4.428 -1.25 Td [(com)10(pl)-31(ica)15.1(t)-32(ions: a new p)25(r)-32(oposal wi)-24(t)-12.9(h ev)-15(al)35(ua)15(t)-32(ion in a cohor)-22(t of 6336 )]TJ -0.023 Tw T* [(p)32(a)15(t)-32(ients and r)-24(esul)56(ts of a sur)-32(ve)-10.9(y. )]TJ /T1_3 1 Tf [(Annals of Surg)12(er)-42.9(y.)]TJ /T1_2 1 Tf ( 2004;240\(2\):205\226)Tj 0.027 Tc 0.95 Tw T* [(2)0.5(1)0.6(3)0.5(.)0.5( )0.5(P)0.5(M)0.5(I)0.5(D)0.6(:)0.5( )0.5(1)0.5(5)0.5(2)0.5(7)0.6(3)0.5(5)0.5(4)0.5(2)0.5(.)0.6( P)0.6(M)0.5(C)0.5(1)0.5(3)0.6(6)0.5(0)0.5(1)0.5(2)0.5(3)0.6(,)0.5( )0.5(d)-15.5(o)0.5(i)0.5(:)]TJ /Span<>> BDC 21.129 0 Td ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs -0.027 Tw 1.21 0 Td [(1)0.5(0)0.5(.)0.6(1)0.5(0)0.5(9)0.5(7)0.5(/)0.6(0)0.5(1)0.5(.)]TJ 0 Tc 0 Tw -22.338 -1.25 Td [(sl)-16(a.0000133083.54934.ae)]TJ 0 0 0 1 k /GS1 gs 0.167 Tw T* (13.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(S)15(tuar)-21.9(t)]TJ /Span<>> BDC ( )Tj EMC (A, Ignell)Tj /Span<>> BDC ( )Tj EMC [(C, \326r)-15(n\366 A K. Com)10(p)32(ar)-36.9(ison of tr)-33(ansper)-37(ineal and )]TJ 0.13 Tw -1.796 -1.25 Td [(end)-16(oanal ul)56.1(tr)-33(asound in de)-12(tec)-15.9(t)-32(ing r)-24(esidual )0.5(obste)-12(tr)-37(ic )0.5(anal sphinc)-16(ter )]TJ 0 Tw T* [(injur)-23.9(y. )]TJ /T1_3 1 Tf -0.047 Tw 2.861 0 Td (Acta Obstet Gynecol Scand. )Tj /T1_2 1 Tf [(2019;98:1624\2261631. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1111/)Tj -2.861 -1.25 Td [(ao)-16(gs.13701)]TJ /T1_1 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 42.5896 444.7359 Tm (REFERENCES)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf 0 Tc 8 0 0 8 42.5197 431.9012 Tm (1.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(P)30(er)-32(gial)-30.9(io)17(t)-32(is)]TJ /Span<>> BDC ( )Tj EMC [(V, Bell)30(os)]TJ /Span<>> BDC ( )Tj EMC [(I, )0.5(F)19.9(anak)-15.9(i)]TJ /Span<>> BDC ( )Tj EMC [(M, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. R)-24(isk )0.5(f)16(a)-17(c)-16(t)17(or)-10(s for )0.5(sever)-24(e per)-36.9(i)]TJ 0 Tw (-)Tj 0.093 Tw -1.296 -1.25 Td [(neal tr)-33(auma dur)-36.9(ing childbir)-22(t)-12.9(h: An upd)42(a)15(ted me)-12(t)15(a-anal)35(y)-13(sis. )]TJ /T1_3 1 Tf 0 Tw (European )Tj 0.007 Tc 0.349 Tw T* [(Jour)-13.6(nal of Obstetr)-36.6(ics and Gynecology and R)21.3(ep)46.4(roductiv)13.3(e Biology.)]TJ /T1_2 1 Tf 0 Tc 0 Tw 27.638 0 Td ( )Tj 0.023 Tw -27.638 -1.25 Td [(2020;247:94\226100. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw [(10.1016/j.ejo)-16(gr)-23.9(b.2020.02.025)]TJ 0 0 0 1 k /GS1 gs 0.013 Tc 0.466 Tw T* (2.)Tj /Span<>> BDC ( )Tj EMC 1.334 0 Td [(Bl)30.3(omquist)]TJ /Span<>> BDC ( )Tj EMC (JL, Mu\361oz)Tj /Span<>> BDC ( )Tj EMC [(A, Car)-23.7(r)-31.6(oll)]TJ /Span<>> BDC ( )Tj EMC [(M, e)-11.6(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Asso)-15.7(c)-23.6(ia)15.4(t)-31.7(ion of)13( )]TJ 0 Tc 0.193 Tw -1.334 -1.25 Td [(Del)-31(i)-16(ver)-23.9(y M)-23.9(ode W)-16(i)-23.9(t)-13(h P)30.1(el)30(v)-16(ic Fl)30(o)-16(or Disor)-23.9(der)-10(s Af)-28(ter Childbir)-22(t)-13(h. )]TJ /T1_3 1 Tf 0 Tw [(J)30(AMA. )]TJ /T1_2 1 Tf 0.023 Tw T* [(2018;320:2438\2262447. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw [(10.1001/J)15(AMA.2018.18315)]TJ 0 0 0 1 k /GS1 gs -0.031 Tw T* (3.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(KM G, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Can we im)10(p)25(r)-32(ove on t)-13(he dia)-16.9(gnosis of t)-13(hir)-24(d degr)-23.9(ee tear)-10(s? )]TJ /T1_3 1 Tf 0.221 Tw -1.296 -1.25 Td [(Eur J Obstet Gynecol R)21(ep)46(rod Biol. )]TJ /T1_2 1 Tf [(2002;101:19\22621. d)-15.9(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1016/)Tj T* (S0301-2115\(01\)00495-X)Tj 0 0 0 1 k /GS1 gs 0.289 Tw T* (4.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(F)20(ar)-24(r)-33(ar)]TJ /Span<>> BDC ( )Tj EMC [(D, T)60(uf)-56(fnell)]TJ /Span<>> BDC ( )Tj EMC [(DJ, R)-10(ama)-17(ge)]TJ /Span<>> BDC ( )Tj EMC [(C. Inter)-31.9(vent)-32(ions for w)-14(omen in )]TJ 0.061 Tw -1.296 -1.25 Td [(subsequent p)25(r)-23.9(egnanc)-24(ies foll)30(o)-13.9(wing obste)-12(tr)-37(ic anal sphinc)-15.9(ter injur)-24(y t)17(o )]TJ 0.113 Tw T* [(r)-24(educe )0.5(t)-13(he r)-37(isk )0.5(of r)-24(ecur)-23.9(r)-24(ent injur)-23.9(y and )0.5(asso)-16(c)-24(ia)15(ted har)-15.9(ms. )]TJ /T1_3 1 Tf 0 Tw (Cochrane )Tj 0.009 Tw T* [(Database of Systematic R)21.1(evie)10(ws.)]TJ /T1_2 1 Tf [( 2014;2014. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1002/14651858.)Tj T* (CD010374.pub2)Tj 0 0 0 1 k /GS1 gs 0.005 Tc 0.349 Tw T* (5.)Tj /Span<>> BDC ( )Tj EMC 1.31 0 Td [(P)40.2(andi)-23.8(t)]TJ /Span<>> BDC ( )Tj EMC [(B. Mana)-16.8(gement of T)47.2(hir)-23.7(d and F)10.2(our)-21.8(t)-12.8(h-degr)-23.7(ee P)30.2(er)-36.8(ineal)5( )]TJ 0 Tc 0 Tw -1.31 -1.25 Td [(T)40(ear)-10(s. )]TJ /T1_3 1 Tf 0.036 Tw 2.63 0 Td [(Smar)-39.9(t Obstet Gynecol Handb.)]TJ /T1_2 1 Tf [( 2018;101\226101. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.5005/jp/)Tj -2.63 -1.25 Td [(bo)-16(ok)-10(s/13082_12)]TJ 0 0 0 1 k /GS1 gs 0.169 Tw T* (6.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Sul)56(t)15(an)]TJ /Span<>> BDC ( )Tj EMC [(A)58.1(H, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Anal end)-16(osono)-16(gr)-33(aphy and cor)-24(r)-24(el)-16(a)15(t)-31.9(ion wi)-24(t)-13(h in )]TJ -0.048 Tw -1.296 -1.25 Td [(v)-16(i)-24(tr)-31.9(o and in v)-15.9(i)-16(vo ana)15(t)17(omy. )]TJ /T1_3 1 Tf (Br J Surg.)Tj /T1_2 1 Tf [( 1993;80:508\226511. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1002/)Tj T* (bjs.1800800435)Tj 0 0 0 1 k /GS1 gs 0.052 Tw T* (7.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(T)47(hak)-17(ar)]TJ /Span<>> BDC ( )Tj EMC [(R, Sul)56(t)15(an)]TJ /Span<>> BDC ( )Tj EMC [(A)58(H. Anal end)-16(osono)-16(gr)-33(aphy and i)-24(ts r)-31.9(ole in assess)]TJ 0 Tw (-)Tj 0.285 Tw -1.296 -1.25 Td [(ing t)-13(he incont)-32(inent p)32(a)15(t)-32(ient. )]TJ /T1_3 1 Tf [(Best Practice and R)21(esearch: Clinical )]TJ 0.149 Tw T* [(Obstetr)-36.9(ics and Gynaecology.)]TJ /T1_2 1 Tf [( 2004;18:157\226173. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1016/j.bpo)Tj (-)Tj T* [(bg)16(yn.2003.09.007)]TJ 0 0 0 1 k /GS1 gs -0.024 Tw 29.055 30 Td (8.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (Oom)Tj /Span<>> BDC ( )Tj EMC 1.985 0 Td [(DMJ, )0.6(W)21.9(est)]TJ /Span<>> BDC ( )Tj EMC 4.166 0 Td [(RL, )0.6(S)-24(chouten)]TJ /Span<>> BDC ( )Tj EMC 5.372 0 Td [(WR, )0.6(e)-12(t)]TJ /Span<>> BDC ( )Tj EMC 2.664 0 Td [(al. )0.6(De)-12(tec)-16(t)-32(ion )0.6(of )0.5(anal )0.6(sphinc)-16(ter )]TJ 0.048 Tw -15.483 -1.25 Td [(defec)-16(ts in female p)32(a)15(t)-32(ients wi)-23.9(t)-13(h fecal incont)-32(inence: A com)10(p)32(ar)-37(ison of )]TJ 0.02 Tw T* [(3-dimensional tr)-32.9(ansper)-37(ineal ul)56.1(tr)-33(asound and 2-dimensional end)-16(oanal )]TJ 0.004 Tc -0.004 Tw T* [(ul)55.9(tr)-33.1(asound. )]TJ /T1_3 1 Tf 0.35 Tw 5.238 0 Td [(Dis Colon R)21(ectum.)]TJ /T1_2 1 Tf ( 2012;)Tj /T1_3 1 Tf 0 Tc 0 Tw (5)Tj /T1_2 1 Tf 0.004 Tc 0.35 Tw 11.163 0 Td [(5:646\226652. )0.5(d)-16.1(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs -0.004 Tw 7.47 0 Td (10.1097/)Tj 0 Tc 0 Tw -23.87 -1.25 Td (DCR.0b013e318251dca1)Tj 0 0 0 1 k /GS1 gs 0.107 Tw T* (9.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(A)-14(br)-33(ams)]TJ /Span<>> BDC ( )Tj EMC 3.328 0 Td [(P, )0.5(Ander)-9.9(sson )0.5(K-E, )0.6(Apost)17(ol)-31(idis)]TJ /Span<>> BDC ( )Tj EMC 12.271 0 Td [(A, )0.5(e)-12(t)]TJ /Span<>> BDC ( )Tj EMC 2.249 0 Td [(al. )0.6(6t)-13(h )0.5(Inter)-14.9(na)15(t)-32(ional )]TJ 0.022 Tc 0.809 Tw -19.144 -1.25 Td [(Consul)55.6(t)14.6(a)14.6(t)-32.4(ion on Incont)-32.4(inence. R)12.6(ecommend)41.6(a)14.6(t)-32.4(ions of t)-13.4(he)22( )]TJ 0 Tc 0.228 Tw T* [(Inter)-15(na)15.1(t)-32(ional S)-23.9(c)-24(ient)-32(if)-28(ic Commi)-24(t)-30(tee: EV)37(AL)50.1(U)17.9(A)15.1(TION A)51.1(ND TREA)15(TMENT )]TJ 0.163 Tw T* [(OF URIN)13(AR)-14(Y INC)13(ONTINENCE, PEL)65(VIC ORGA)51.1(N PROL)-34.9(APSE A)51(ND F)24(AEC)20(AL )]TJ 0.012 Tc -0.012 Tw T* [(IN)0.5(C)13.4(ON)0.5(TIN)0.5(ENC)0.5(E.)0.5( )]TJ /T1_3 1 Tf 0.428 Tw 7.127 0 Td [(N)18.4(e)0.5(uro)0.5(ur)0.5(ol U)22.4(ro)0.5(dyn)]TJ /T1_2 1 Tf 7.461 0 Td [(. 2)0.5(018)0.5( Sep)0.5(;37)0.5(\(7\))0.5(:22)0.5(71\226)0.5(2272)0.5(.)12( )]TJ 0 Tc 0 Tw -14.588 -1.25 Td [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td [(10.1002/N)13(A)17(U.23551)]TJ 0 0 0 1 k /GS1 gs 0.132 Tw -1.847 -1.25 Td (10.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Hull)Tj /Span<>> BDC ( )Tj EMC (TL, Milsom)Tj /Span<>> BDC ( )Tj EMC [(JW. P)30(el)30(v)-16(ic fl)30(o)-16(or disor)-23.9(der)-10(s. )]TJ /T1_3 1 Tf [(Surg Clin N)17(or)-40(th Am)]TJ /T1_2 1 Tf 0 Tw (. )Tj 0.023 Tw -1.796 -1.25 Td [(1994 Dec;74\(6\):1399\226413. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1016/S0039-6109\(16\)46489-3)Tj 0 0 0 1 k /GS1 gs 0.216 Tw T* (11.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Cl)-16(av)-15.9(ien)]TJ /Span<>> BDC ( )Tj EMC [(P, )0.6(Sanabr)-37(ia)]TJ /Span<>> BDC ( )Tj EMC 8.473 0 Td [(J, )0.5(S)15(tr)-33(asber)-31.9(g)]TJ /Span<>> BDC ( )Tj EMC [(S. )0.5(P)35(r)-32(oposed )0.5(cl)-15.9(assif)-28(ica)15(t)-32(ion )0.5(of )]TJ -0.014 Tw -10.269 -1.25 Td [(com)10(pl)-31(ica)15.1(t)-32(ion of sur)-31.9(ger)-24(y wi)-24(t)-13(h e)-18(x)-10.9(am)10(ples of ut)-32(il)-31(i)-24(t)-9.9(y in cholecy)-12.9(stec)-16(t)17(omy. )]TJ /T1_3 1 Tf 0 Tw T* [(Surg)12(er)-43(y)]TJ /T1_2 1 Tf 0.023 Tw (. 1992;111:518\226526. PMID: 1598671.)Tj 0.029 Tw T* (12.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Dind)-16(o)]TJ /Span<>> BDC ( )Tj EMC 2.632 0 Td [(D, Demar)-21.9(t)-32(ines N )0.5(and Cl)-16(av)-15.9(ien)]TJ /Span<>> BDC ( )Tj EMC [(P)25(A. )0.5(Cl)-16(assif)-28(ica)15(t)-31.9(ion of )0.5(sur)-32(gical )]TJ 0.102 Tw -4.428 -1.25 Td [(com)10(pl)-31(ica)15.1(t)-32(ions: a new p)25(r)-32(oposal wi)-24(t)-12.9(h ev)-15(al)35(ua)15(t)-32(ion in a cohor)-22(t of 6336 )]TJ -0.023 Tw T* [(p)32(a)15(t)-32(ients and r)-24(esul)56(ts of a sur)-32(ve)-10.9(y. )]TJ /T1_3 1 Tf [(Annals of Surg)12(er)-42.9(y)]TJ /T1_2 1 Tf (. 2004;240\(2\):205\226)Tj 0.027 Tc 0.95 Tw T* [(2)0.5(1)0.6(3)0.5(.)0.5( )0.5(P)0.5(M)0.5(I)0.5(D)0.6(:)0.5( )0.5(1)0.5(5)0.5(2)0.5(7)0.6(3)0.5(5)0.5(4)0.5(2)0.5(.)0.6( P)0.6(M)0.5(C)0.5(1)0.5(3)0.6(6)0.5(0)0.5(1)0.5(2)0.5(3)0.6(,)0.5( )0.5(d)-15.5(o)0.5(i)0.5(:)]TJ /Span<>> BDC 21.129 0 Td ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs -0.027 Tw 1.21 0 Td [(1)0.5(0)0.5(.)0.6(1)0.5(0)0.5(9)0.5(7)0.5(/)0.6(0)0.5(1)0.5(.)]TJ 0 Tc 0 Tw -22.338 -1.25 Td [(sl)-16(a.0000133083.54934.ae)]TJ 0 0 0 1 k /GS1 gs 0.167 Tw T* (13.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(S)15(tuar)-21.9(t)]TJ /Span<>> BDC ( )Tj EMC (A, Ignell)Tj /Span<>> BDC ( )Tj EMC [(C, \326r)-15(n\366 A K. Com)10(p)32(ar)-36.9(ison of tr)-33(ansper)-37(ineal and )]TJ 0.13 Tw -1.796 -1.25 Td [(end)-16(oanal ul)56.1(tr)-33(asound in de)-12(tec)-15.9(t)-32(ing r)-24(esidual )0.5(obste)-12(tr)-37(ic )0.5(anal sphinc)-16(ter )]TJ 0 Tw T* [(injur)-23.9(y. )]TJ /T1_3 1 Tf -0.047 Tw 2.861 0 Td (Acta Obstet Gynecol Scand. )Tj /T1_2 1 Tf [(2019;98:1624\2261631. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1111/)Tj -2.861 -1.25 Td [(ao)-16(gs.13701)]TJ /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\033\030\031\030\213\b)-20.9(\035\231\213\233\t \021\032)50(\b)42(\032\231\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj /T1_4 1 Tf 25 0 0 25 512.0145 56.0378 Tm (81)Tj ET endstream endobj 1725 0 obj <>/Border[0 0 0]/H/N/Rect[119.02 689.291 217.443 679.995]/Subtype/Link/Type/Annot>> endobj 1726 0 obj <>/Border[0 0 0]/H/N/Rect[131.02 659.291 219.355 649.995]/Subtype/Link/Type/Annot>> endobj 1727 0 obj <>/Border[0 0 0]/H/N/Rect[233.71 639.291 263.622 629.835]/Subtype/Link/Type/Annot>> endobj 1728 0 obj <>/Border[0 0 0]/H/N/Rect[42.5197 629.291 121.623 619.995]/Subtype/Link/Type/Annot>> endobj 1729 0 obj <>/Border[0 0 0]/H/N/Rect[199.342 589.291 263.622 579.835]/Subtype/Link/Type/Annot>> endobj 1730 0 obj <>/Border[0 0 0]/H/N/Rect[42.5197 579.291 93.2315 569.995]/Subtype/Link/Type/Annot>> endobj 1731 0 obj <>/Border[0 0 0]/H/N/Rect[223.918 559.291 263.622 549.835]/Subtype/Link/Type/Annot>> endobj 1732 0 obj <>/Border[0 0 0]/H/N/Rect[42.5197 549.291 96.9594 539.995]/Subtype/Link/Type/Annot>> endobj 1733 0 obj <>/Border[0 0 0]/H/N/Rect[233.71 529.291 263.622 519.835]/Subtype/Link/Type/Annot>> endobj 1734 0 obj <>/Border[0 0 0]/H/N/Rect[42.5197 519.291 94.2315 509.995]/Subtype/Link/Type/Annot>> endobj 1735 0 obj <>/Border[0 0 0]/H/N/Rect[214.278 489.291 263.622 479.835]/Subtype/Link/Type/Annot>> endobj 1736 0 obj <>/Border[0 0 0]/H/N/Rect[42.5197 479.291 101.207 469.995]/Subtype/Link/Type/Annot>> endobj 1737 0 obj <>/Border[0 0 0]/H/N/Rect[465.921 689.291 496.063 679.835]/Subtype/Link/Type/Annot>> endobj 1738 0 obj <>/Border[0 0 0]/H/N/Rect[274.961 679.291 352.664 669.995]/Subtype/Link/Type/Annot>> endobj 1739 0 obj <>/Border[0 0 0]/H/N/Rect[289.739 619.291 355.674 609.995]/Subtype/Link/Type/Annot>> endobj 1740 0 obj <>/Border[0 0 0]/H/N/Rect[379.111 599.291 488.279 589.995]/Subtype/Link/Type/Annot>> endobj 1741 0 obj <>/Border[0 0 0]/H/N/Rect[453.665 529.291 496.063 519.995]/Subtype/Link/Type/Annot>> endobj 1742 0 obj <>/Border[0 0 0]/H/N/Rect[274.961 519.291 358.52 509.995]/Subtype/Link/Type/Annot>> endobj 1743 0 obj <>/Border[0 0 0]/H/N/Rect[466.151 489.291 496.063 479.835]/Subtype/Link/Type/Annot>> endobj 1744 0 obj <>/Border[0 0 0]/H/N/Rect[274.961 479.291 312.272 469.995]/Subtype/Link/Type/Annot>> endobj 1745 0 obj <>/Border[0 0 0]/H/N/Rect[119.02 409.197 217.443 399.901]/Subtype/Link/Type/Annot>> endobj 1746 0 obj <>/Border[0 0 0]/H/N/Rect[131.02 379.197 219.355 369.901]/Subtype/Link/Type/Annot>> endobj 1747 0 obj <>/Border[0 0 0]/H/N/Rect[233.71 359.197 263.622 349.741]/Subtype/Link/Type/Annot>> endobj 1748 0 obj <>/Border[0 0 0]/H/N/Rect[42.5197 349.197 121.623 339.901]/Subtype/Link/Type/Annot>> endobj 1749 0 obj <>/Border[0 0 0]/H/N/Rect[199.342 309.197 263.622 299.741]/Subtype/Link/Type/Annot>> endobj 1750 0 obj <>/Border[0 0 0]/H/N/Rect[42.5197 299.197 93.2315 289.901]/Subtype/Link/Type/Annot>> endobj 1751 0 obj <>/Border[0 0 0]/H/N/Rect[223.918 279.197 263.622 269.741]/Subtype/Link/Type/Annot>> endobj 1752 0 obj <>/Border[0 0 0]/H/N/Rect[42.5197 269.197 96.9594 259.901]/Subtype/Link/Type/Annot>> endobj 1753 0 obj <>/Border[0 0 0]/H/N/Rect[233.71 249.197 263.622 239.741]/Subtype/Link/Type/Annot>> endobj 1754 0 obj <>/Border[0 0 0]/H/N/Rect[42.5197 239.197 94.2315 229.901]/Subtype/Link/Type/Annot>> endobj 1755 0 obj <>/Border[0 0 0]/H/N/Rect[214.278 209.197 263.622 199.741]/Subtype/Link/Type/Annot>> endobj 1756 0 obj <>/Border[0 0 0]/H/N/Rect[42.5197 199.197 101.207 189.901]/Subtype/Link/Type/Annot>> endobj 1757 0 obj <>/Border[0 0 0]/H/N/Rect[465.921 409.197 496.063 399.741]/Subtype/Link/Type/Annot>> endobj 1758 0 obj <>/Border[0 0 0]/H/N/Rect[274.961 399.197 352.664 389.901]/Subtype/Link/Type/Annot>> endobj 1759 0 obj <>/Border[0 0 0]/H/N/Rect[289.739 339.197 355.674 329.901]/Subtype/Link/Type/Annot>> endobj 1760 0 obj <>/Border[0 0 0]/H/N/Rect[379.111 319.197 488.279 309.901]/Subtype/Link/Type/Annot>> endobj 1761 0 obj <>/Border[0 0 0]/H/N/Rect[453.665 249.197 496.063 239.901]/Subtype/Link/Type/Annot>> endobj 1762 0 obj <>/Border[0 0 0]/H/N/Rect[274.961 239.197 358.52 229.901]/Subtype/Link/Type/Annot>> endobj 1763 0 obj <>/Border[0 0 0]/H/N/Rect[466.151 209.197 496.063 199.741]/Subtype/Link/Type/Annot>> endobj 1764 0 obj <>/Border[0 0 0]/H/N/Rect[274.961 199.197 312.272 189.901]/Subtype/Link/Type/Annot>> endobj 1804 0 obj <> endobj 1803 0 obj <> endobj 1802 0 obj <> endobj 1801 0 obj <> endobj 1800 0 obj <> endobj 1799 0 obj <> endobj 1798 0 obj <> endobj 1797 0 obj <> endobj 1796 0 obj <> endobj 1795 0 obj <> endobj 1794 0 obj <> endobj 1793 0 obj <> endobj 1792 0 obj <> endobj 1791 0 obj <> endobj 1790 0 obj <> endobj 1789 0 obj <> endobj 1788 0 obj <> endobj 1787 0 obj <> endobj 1786 0 obj <> endobj 1785 0 obj <> endobj 1784 0 obj <> endobj 1783 0 obj <> endobj 1782 0 obj <> endobj 1781 0 obj <> endobj 1780 0 obj <> endobj 1779 0 obj <> endobj 1778 0 obj <> endobj 1777 0 obj <> endobj 1776 0 obj <> endobj 1775 0 obj <> endobj 1774 0 obj <> endobj 1773 0 obj <> endobj 1772 0 obj <> endobj 1771 0 obj <> endobj 1770 0 obj <> endobj 1769 0 obj <> endobj 1768 0 obj <> endobj 1767 0 obj <> endobj 1766 0 obj <> endobj 1765 0 obj <> endobj 1468 0 obj <>/Font<>/ProcSet[/PDF/Text/ImageC]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1469 0 obj <>/Font<>/ProcSet[/PDF/Text/ImageC]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1470 0 obj <>/Font<>/ProcSet[/PDF/Text/ImageC]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1471 0 obj <>/Font<>/ProcSet[/PDF/Text/ImageC]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1472 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1816 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.008 Tc 0.243 Tw 10 0 0 10 70.8661 724.8299 Tm (\017)Tj /Span<>> BDC ( )Tj EMC (\031\020\035\024\n \024\f\021\026\021\024\004\027\024\020\024 \007\036\235\ \036\022\021\026 \r\027\031\021\030\036\027\027\036\020\024 \f\235\017\027\ \022)Tj 0 Tc 0 Tw (-)Tj 0.008 Tc 0.109 Tw 0 -1.218 TD (\021\036\030\026, \017\n\036\030\016\036\n\t\n \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\023\024\n\024\013\017 \230\215\211\003\222. \230\026\022\017\n \024\002\ \030\026)Tj 0 Tc 0 Tw (-)Tj 0.008 Tc 0.139 Tw T* [(\024\n, )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 2.956 0 Td [(\017\f\f\035\036\007\024\r\026\027\017\017 )0.5(\002\t\035\024 )0.6(\023\030\024\007\036\n\024\027\f\021\030\017\030\024\r\026\027\024)]TJ /Span<>> BDC ( )Tj EMC 18.154 0 Td [(\227)8( )]TJ 0.54 Tw -21.11 -1.218 Td [(\004\036\n \002\024\035\034\001\036 \024\023\030\036\007\036\035\016\036\ \n\t\005 \007\036\235\036\022\021 \r\027\031\021\030\036\027\027\036\020\ \024)8( )]TJ 0.287 Tw T* [(\f\235\017\027\022\021\036\030\026, \021\036\n \n\036\027\036\036 \220\235\ \235\036\022\021\017\r\027\024 \b\017\030\031\030\020\017\004\036\f\022\024\ \036)8( )]TJ -0.008 Tw T* (\035\036\004\036\027\017\036.)Tj 0 Tc 0.109 Tw 0 -1.218 TD (\215\024\035\031\004\036\027\027\t\036 \027\026\n\017 \030\036\031\035\034\ \021\026\021\t \027\036\f\022\024\035\034\022\024 \024\021\035\017\004\026\ \033\021\f\016 )Tj 0.202 Tw 0 -1.218 TD (\024\021 \r\t\001\036\024\023\017\f\026\027\027\t\b, \021\026\022 \022\026\ \022 \031\002\036\007\017\021\036\035\034\027\024\005 \022\024\030\030\036\ \035\016)Tj 0 Tw (-)Tj 0.188 Tw T* (\006\017\024\027\027\024\005 \r\026\017\n\024\f\r\016\017 \n\036\032\007\ \031 \f\021\036\023\036\027\034\033 \027\036\007\036\030\032\026\027\017\ \016 )Tj 0.025 Tw T* (\023\024\f\035\036 \b\017\030\031\030\020\017\004\036\f\022\024\020\024 \ \035\036\004\036\027\017\016, \024\006\036\027\017\r\026\036\n\024\005 \023\ \030\017)Tj /Span<>> BDC ( )Tj EMC (\023\024)Tj 0 Tw (-)Tj 0.199 Tw T* (\n\024\013\017 \024\023\030\024\f\027\017\022\024\r \017)Tj /Span<>> BDC ( )Tj EMC [(\023\024\022\026\026\021\036\035\036\005 )0.5(\224\217\211\003\222 )0.5(\017\035\017 )0.5(\230\215\211\003\222 )]TJ 0.15 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\220\235\235\036\022\021\017\r\027\024\f\021\034\033 \f\235\017\027\022\021\ \036\030\024\023\035\026\f\021\017\022\017 \023\024\035\031\004\036\027\024\ \027\036 )Tj 0.286 Tw 0 -1.218 TD (\002\t\035\024. \210\007\027\026\022\024 \r)Tj /Span<>> BDC ( )Tj EMC (\024\021\035\017\004\017\036 \024\021 \027\026\001\036\020\024 \017\f\f\035\ \036\007\024\r\026\027\017\016, )Tj 0.042 Tw 0 -1.218 TD [(Cl)-16(aes Ignell \017)]TJ /Span<>> BDC ( )Tj EMC (\f\024\026\r\021\024\030\t [5] \024\006\036\027\017\r\026\035\017 \r\t\030\ \026\032\036\027\027\024\f\021\034 )Tj 0.215 Tw 0 -1.218 TD (\027\036\007\036\030\032\026\027\017\016 \017)Tj /Span<>> BDC ( )Tj EMC (\f\021\036\023\036\027\034 \023\024\f\035\036\030\024\007\024\r\024\005 \ \021\030\026\r\n\t \031)Tj /Span<>> BDC ( )Tj EMC (\023\026)Tj 0 Tw (-)Tj 0.143 Tw T* (\006\017\036\027\021\024\022 \023\024\f\035\036 \023\036\030\r\017\004\027\ \024\020\024 \b\017\030\031\030\020\017\004\036\f\022\024\020\024 \035\036\ \004\036\027\017\016, )Tj 0.043 Tw T* [(\023\030\024\017\r\036\007\036\027\027\024\020\024 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC [(\030\024\007\024\r\024\n )0.5(\026\035\036. \215\024\022\026\026\021\036\035\017 )0.5(\007\024)]TJ /Span<>> BDC ( )Tj EMC (\024\023\036)Tj 0 Tw (-)Tj -0.01 Tw T* [(\030\026\006\017\017 )0.5(\027\036 )0.6(\024\006\036\027\017\r\026\035\017\f\034, )0.5(\026)]TJ /Span<>> BDC ( )Tj EMC 10.336 0 Td [(\023\024\f\035\036\024\023\036\030\026\006\017\024\027\027\t\036 )0.6(\030\036\031\035\034)]TJ 0 Tw (-)Tj 0.053 Tw -10.336 -1.218 Td (\021\026\021\t \026\027\026\035\017\017\030\024\r\026\035\017\f\034 \004\ \036\030\036 6 \n\036\f\016\006\036\r \023\024\f\035\036 \b\017\030\031\ \030)Tj 0 Tw (-)Tj T* (\020\017\004\036\f\022\024\020\024 \035\036\004\036\027\017\016.)Tj 0.115 Tw T* [(\200 )0.5(\024\021\035\017\004\017\036 )0.5(\024\021 )0.5(\r\t\001\036\024\023\017\f\026\027\027\024\020\024 )0.5(\017\f\f\035\036\007\024\r\026\027\017\016, )0.6(\027\026\001\036\005 )]TJ -0.03 Tw T* (\006\036\035\034\033 \002\t\035\024 \024\023\030\036\007\036\035\017\021\ \034 \023\030\024\020\027\024\f\021\017\004\036\f\022\031\033 \027\026\004\ \017\n\024\f\021\034 )Tj 0.16 Tw T* (\023\024\022\026\026\021\036\035\036\005, \023\024\035\031\004\026\036\n\ \t\b \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\007\024\024\023\036\030\026\006\017\024\027\027\024\n \031\035\034)Tj 0 Tw (-)Tj 0.128 Tw T* [(\021\030\026\r\031\022\024\r\024\n \017\f\f\035\036\007\024\r\026\027\017\ \017 )0.5(\027\026)]TJ /Span<>> BDC ( )Tj EMC (\031\f\023\036\001\027\024\f\021\034 \r\t\023\024\035\027\036)Tj 0 Tw (-)Tj 0.358 Tw T* (\027\017\016 \024\021\f\030\024\004\036\027\027\024\005 \f\235\017\027\022\ \021\036\030\024\023\035\026\f\021\017\022\017 \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\022 )Tj 0 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\023\024\f\035\036\030\024\007\024\r\t\n \026\027\026\035\034\027\t\n \027\ \036\007\036\030\032\026\027\017\036\n.)Tj 0.338 Tw T* (\215\030\017 \026\027\026\035\017\036 \023\024\035\031\004\036\027\027\t\ \b \030\036\031\035\034\021\026\021\024\r, \027\036 \031\007\026\035\024\ \f\034 )Tj 0.27 Tw T* (\r\t\016\r\017\021\034 \022\024\030\030\036\035\016\006\017\024\027\027\t\ \b \r\026\017\n\024\f\r\016\036\005 \n\036\032\007\031 \023\024)Tj 0 Tw (-)Tj 0.016 Tw T* (\022\026\026\021\036\035\016\n\017 \023\030\036\007\024\023\036\030\026\ \006\017\024\027\027\024\005 \031\035\034\021\030\026\r\031\022\024\r\024\ \005 \007\017\026\020)Tj 0 Tw (-)Tj 0.108 Tw T* (\027\024\f\021\017\022\017 \017)Tj /Span<>> BDC ( )Tj EMC (\220\235\235\036\022\021\017\r\027\024\f\021\034\033 \b\017\030\031\030\020\ \017\004\036\f\022\024\020\024 \035\036\004\036\027\017\016 )Tj 0.462 Tw T* (\023\024\f\035\036\030\024\007\024\r\024\020\024 \026\027\026\035\034\027\ \024\020\024 \027\036\007\036\030\032\026\027\017\016. \215\030\017)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\n )Tj 0.075 Tw T* (\027\026\001\036 \026\022\035\033\004\036\027\017\036 \027\036 \024\021\ \030\017\006\026\036\021 \020\035\026\r\036\027\f\021\r\031\033\013\036\005\ \030\024\035\017 )Tj 0.121 Tw T* (\224\217\211\003\222 \r)Tj /Span<>> BDC ( )Tj EMC (\024\006\036\027\022\036 \f\021\036\023\036\027\017 \023\024\r\030\036\032\ \007\036\027\017\016 \023\030\024\n\036\032\027\024\f\021\017 )Tj 0.05 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\027\036\026\n\036\027\017\n\024\f\021\017 \220\021\024\020\024 \n\036\021\ \024\007\026 \007\017\026\020\027\024\f\021\017\022\017 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\023\035\026)Tj 0 Tw (-)Tj 0.704 Tw T* (\027\017\030\024\r\026\027\017\017 \b\017\030\031\030\020\017\004\036\f\022\ \024\020\024 \035\036\004\036\027\017\016. \217\036\031\035\034\021\026\ \021\t )Tj 0.305 Tw T* (\017\f\f\035\036\007\024\r\026\027\017\016, \r)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\r\031\033 \024\004\036\030\036\007\034, \f\r\017\007\036\021\ \036\035\034\f\021\r\031\033\021 )Tj 0.123 Tw T* (\024)Tj /Span<>> BDC ( )Tj EMC (\021\024\n, \004\021\024 \030\026\n\036\030 \007\036\235\036\022\021\026\ \f\235\017\027\022\021\036\030\027\024\020\024 \022\024\n\023\035\036\022\ \f\026 )Tj 0.18 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\017\036 \023\026\030\026\n\036\021\030\t, \022\026\022 \030\ \026\n\036\030 \007\036\235\036\022\021\026 \027\026\030\031\032\027\024\ \020\024 )Tj 0.054 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC 0.804 0 Td [(\r\027\031\021\030\036\027\027\036\020\024 )0.6(\f\235\017\027\022\021\036\030\024\r, )0.5(\021\024\035\013\017\027\026 )0.6(\027\024\032\036\022 )0.5(m.lev)-15(a)15(t)17.1(or )]TJ 0.146 Tw -0.804 -1.218 Td [(ani, )0.5(\026)]TJ /Span<>> BDC ( )Tj EMC [(\021\026\022\032\036 )0.5(\031\020\024\035 \017\b )0.5(\r\023\035\036\021\036\027\017\016 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC [(\023\030\024\007\024\035\034\027\031\033 )0.5(\n\t\001)]TJ 0 Tw (-)Tj 0.22 Tw T* (\006\031 \026\027\026\035\034\027\024\020\024 \022\026\027\026\035\026, \ \026\027\024\030\036\022\021\026\035\034\027\t\005 \031\020\024\035 \r)Tj /Span<>> BDC ( )Tj EMC (\023\024\022\024\036, )Tj 0.194 Tw T* (\023\030\017)Tj /Span<>> BDC ( )Tj EMC (\027\026\021\031\032\017\r\026\027\017\017 \017)Tj /Span<>> BDC ( )Tj EMC (\f\032\026\021\017\017, \026\n\023\035\017\021\031\007\026 \f\024\022\030\ \026\013\036\027\017\016 )Tj 0.125 Tw T* (\023\031\002\024\030\036\022\021\026\035\034\027\024\005 \n\t\001\006\t,\ \027\026\035\017\004\017\036 \030\036\022\021\024\006\036\035\036 \017)Tj /Span<>> BDC ( )Tj EMC (\017\027\r\026)Tj 0 Tw (-)Tj 0.107 Tw T* (\020\017\027\026\006\017\017 \023\030\016\n\024\005 \022\017\001\022\017\ \027\036 \r\035\017\016\033\021 \027\026)Tj /Span<>> BDC ( )Tj EMC (\030\036\031\035\034\021\026\021 \r\021\024)Tj 0 Tw (-)Tj 0.088 Tw T* (\030\017\004\027\024\005 \(\024\021\f\030\024\004\036\027\027\024\005\) \ \f\235\017\027\022\021\036\030\024\023\035\026\f\021\017\022\017. \025\030\ \031\023\027\t\036 )Tj 0.484 Tw T* (\007\036\235\036\022\021\t \026\027\026\035\034\027\t\b \f\235\017\027\022\ \021\036\030\024\r \(\002\024\035\036\036 120)Tj 0 Tw (\260)Tj 0.484 Tw (\) \027\036 )Tj 0.098 Tw T* (\007\024\035\032\027\t \024\f\021\026\027\026\r\035\017\r\026\021\034 \b\ \017\030\031\030\020\024\r \024\021 \026\022\021\017\r\027\024\005 \b\017\ \030\031\030)Tj 0 Tw (-)Tj T* (\020\017\004\036\f\022\024\005 \021\026\022\021\017\022\017.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 70.936 115.9298 Tm [(\020)21(\026\027\r\242\224\034\022\031\034)]TJ 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0 Tc 0.219 Tw 10 0 0 10 70.8661 91.5738 Tm [(\224\235\235\036\022\021\017\r\027\024\f\021\034 )0.6(\024\021\f\030\024\004\036\027\027\024\020\024 )0.5(\b\017\030\031\030\020\017\004\036\f\022\024\020\024 )0.6(\035\036\004\036)]TJ 0 Tw (-)Tj 0.11 Tw T* (\027\017\016 \026\027\026\035\034\027\024\005 \017\027\022\024\027\021\017\ \027\036\027\006\017\017 \023\024\f\035\036\030\024\007\024\r\024\020\024\ \020\036\027\036\026 )Tj 0.22 Tw 23.244 64.543 Td (\027\036 \026\r\017\f\017\021 \024\021 \r\036\035\017\004\017\027\t \007\ \036\235\036\022\021\026 \026\027\026\035\034\027\t\b \f\235\017\027\022\ )Tj 0 Tw (-)Tj 0.291 Tw T* [(\021\036\030\024\r, \030\036\020\017\f\021\030\017\030\031\036\n\t\b )0.5(\023\030\017)]TJ /Span<>> BDC ( )Tj EMC [(\026\027\024\030\036\022\021\026\035\034\027\024\005 )0.5(\031\035\034\021\030\026)]TJ 0 Tw (-)Tj 0.435 Tw T* (\r\031\022\024\r\024\005 \007\017\026\020\027\024\f\021\017\022\036. \212\ \026\035\034\027\036\005\001\017\036 \017\f\f\035\036\007\024\r\026\027\017\ \016 )Tj 0.149 Tw T* (\007\024\035\032\027\t \002\t\021\034 \027\026\023\030\026\r\035\036\027\ \t \027\026)Tj /Span<>> BDC ( )Tj EMC (\r\t\016\r\035\036\027\017\036 \023\030\024\020\027\024\f\021\017)Tj 0 Tw (-)Tj 0.582 Tw T* (\004\036\f\022\024\020\024 \023\024\021\036\027\006\017\026\035\026 \031\ \035\034\021\030\026\r\031\022\024\r\024\005 \007\017\026\020\027\024\f\ \021\017\022\017 )Tj 0 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\007\024\035\020\024\f\030\024\004\027\024\n \023\036\030\017\024\007\036\ .)Tj /T1_2 1 Tf 0.023 Tw 0 -2.436 TD (\223\030\032\255\020\034\036 \032\026\020\017\022\017\026)Tj /T1_0 1 Tf 0.125 Tw 0 -1.218 TD [(\025)-4.1(\024)-4.3(\027)1.7(\006)-6(\036)-6.8(\023)2.2(\006)-6(\017)-5.4(\016 \017)]TJ /Span<>> BDC ( )Tj EMC [(\007)-6(\017)2.7()-9.9(\026\005)1.7(\027 \017)-2.4(\f)3.1(\f)-38.9(\035)-6.8(\036)-19(\007)-4.4(\024)-4.3(\r)-8.9(\026\027)1.7(\017)-5.5(\016)13.7(:)]TJ /T1_3 1 Tf -0.01 Tc 0.135 Tw [( \240\026)-8.2(\032)-4(\013)2.7(\026)-8.2(\032)-2.5(\022)-15.7(\002\021)]TJ /Span<>> BDC 19.982 0 Td ( )Tj EMC [(\200)-8.5(.)19.3(\212)83.9(.)-2.2(,)-10( )]TJ 0.01 Tw -19.982 -1.218 Td [(\035)-4.1(\205)-1.2(\013\022)-15.7(\002\021)-6.2(\n\027)]TJ /Span<>> BDC 3.782 0 Td ( )Tj EMC [(\201)-12.3(.)10.1(\240)9.4(.)-2.1(,)-10( \222)6.6(\025)-6.7(\t\031)-30.6(\023)-6.7(\031)-3.3(\027)]TJ /Span<>> BDC 5.673 0 Td ( )Tj EMC [(\200)-8.6(.)33.7(\255)17.7(.)-2.2(,)-10( \201)-3.6(\202)-3.4(\026)-8.2(\033)-5.5(\n\027)]TJ /Span<>> BDC 5.139 0 Td ( )Tj EMC [(\240)9.4(.)-2.7(\201)-12.2(.)]TJ /T1_0 1 Tf 0 Tc 0.861 Tw -14.594 -1.218 Td [(\221)-4.6(\002)-9.9(\024)0.7(\030 \017)]TJ /Span<>> BDC ( )Tj EMC [(\024)-11.8(\002)3(\030)-11.4(\026)-6.3(\002)-9.9(\024)-10.9(\021)-17.7(\022)-19.1(\026 \n)1.3(\026)-11.8(\021)-9.9(\036)-1.7(\030)-7.6(\017)-0.6(\026)-33.1(\035\026)3.7(:)]TJ /T1_3 1 Tf -0.003 Tc 0.864 Tw [( \222)13.6(\025\t)6.8(\031)-23.6(\023\031)3.6(\027)]TJ /Span<>> BDC 19.174 0 Td ( )Tj EMC [(\200)-1.6(.)40.6(\255)24.7(.)4.8(,)-3( )]TJ -0.01 Tc 0.01 Tw -19.174 -1.218 Td [(\240\026)-8.2(\032)-4.1(\013)2.7(\026)-8.1(\032)-2.5(\022)-15.7(\002\021)]TJ /Span<>> BDC 4.382 0 Td ( )Tj EMC [(\200)-8.6(.)19.3(\212)83.9(.)-2.1(,)-10( \035)-4.1(\205)-1.2(\013\022)-15.7(\002\021)-6.1(\n\027)]TJ /Span<>> BDC 6.019 0 Td ( )Tj EMC [(\201)-12.3(.)10.1(\240)9.5(.)]TJ /T1_0 1 Tf 0.018 Tc 1.507 Tw -10.4 -1.218 Td [(\221)35.2(\021)-3.5(\026)6.2(\021\017)15.7(\f)-18(\021\017)22.5(\004)9.8(\036)7.6(\f)16.4(\022)-1.1(\026)-3(\016)18( \024)6.2(\002)21(\030)6.6(\026)11.7(\002)8.1(\024)7.1(\021\022)-1(\026)21.7(:)]TJ /T1_3 1 Tf -0.01 Tc 1.535 Tw 12.874 0 Td [( \035)-4.1(\205)-1.2(\013\022)-15.7(\002\021)-6.2(\n\027)]TJ /Span<>> BDC 5.54 0 Td ( )Tj EMC [(\201)-12.3(.)10.1(\240)9.5(.)-2.2(,)-10( )]TJ 0.01 Tw -18.415 -1.218 Td [(\240\026)-8.2(\032)-4.1(\013)2.7(\026)-8.1(\032)-2.5(\022)-15.7(\002\021)]TJ /Span<>> BDC 4.382 0 Td ( )Tj EMC [(\200)-8.6(.)19.3(\212)83.9(.)]TJ /T1_0 1 Tf 0.002 Tc 0.442 Tw -4.382 -1.218 Td [(\203)7.2(\026\023)4.2(\017\f)-10.8(\026)1.7(\027)3.7(\017)-6.7(\036)2.1( \021)-7.9(\036)-3.3(\022\f)-34(\021)-19.5(\026)5.7(:)]TJ /T1_3 1 Tf 0 Tc 0.444 Tw 8.138 0 Td [( \240)10.2(\026)1.8(\032)5.9(\013)12.7(\026)1.8(\032)7.5(\022)-5.7(\002)10.3(\021)]TJ /Span<>> BDC ( )Tj EMC [(\200)1.4(.)29.3(\212)93.9(.)7.8(, \222)16.6(\025)3.3(\t)9.8(\031)-20.6(\023)3.3(\031)6.6(\027)]TJ /Span<>> BDC ( )Tj EMC [(\200)1.4(.)43.7(\255)27.7(.)7.8(, )]TJ -0.01 Tc 0.01 Tw -8.138 -1.218 Td [(\035)-4.1(\205)-1.2(\013\022)-15.7(\002\021)-6.2(\n\027)]TJ /Span<>> BDC 3.782 0 Td ( )Tj EMC [(\201)-12.3(.)10.1(\240)9.4(.)]TJ /T1_0 1 Tf 0 Tc 0 Tw -3.782 -1.218 Td [(\217)5.5(\036)-19(\007)-20.1(\026\022)-32.6(\021)-17.7(\017)1.4(\030)-11.8(\024)-4.2(\r)-9(\026\027)1.8(\017)-8.7(\036)6.5(:)]TJ /T1_3 1 Tf 0.695 Tw [( \240)10.2(\026)1.8(\032)5.9(\013)12.7(\026)1.8(\032)7.5(\022)-5.7(\002)10.3(\021)]TJ /Span<>> BDC ( )Tj EMC [(\200)1.5(.)29.3(\212)93.9(.)7.8(, \222)16.6(\025)3.3(\t)9.8(\031)-20.6(\023)3.3(\031)6.6(\027)]TJ /Span<>> BDC ( )Tj EMC [(\200)1.3(.)43.8(\255)27.6(.)7.8(, )]TJ -0.007 Tc 0.007 Tw 0 -1.218 TD [(\201)-0.6(\202\026)-5.2(\033)-2.5(\n)2.6(\027)]TJ /Span<>> BDC 2.831 0 Td ( )Tj EMC [(\240)12.4(.\201)-9.3(.)]TJ /T1_2 1 Tf 0 Tc 0.023 Tw -2.831 -2.436 Td (AUTHORS CONTRIBUTION)Tj /T1_0 1 Tf 0.083 Tw 0 -1.218 TD [(C)-6.5(o)0.8(nce)-0.7(p)-12.3(t a)2.4(n)-4.6(d d)-5.5(e)-13.3(s)-16.6(i)3.2(g)1.2(n o)-2.2(f t)-16.7(h)-5.3(e s)-20(t)-12.8(ud)-10.9(y)-11.8(:)]TJ /T1_3 1 Tf [( D)-3.2(a)-0.8(n)6.2(i)3.4(i)7.5(l)]TJ /Span<>> BDC ( )Tj EMC [(R)-2.5(.)]TJ /Span<>> BDC ( )Tj EMC [(M)5.2(ar)-2.5(k)15.9(ar)-40.2(y)3.8(a)-0.8(n)-6(, )]TJ 1.23 Tw 0 -1.218 TD [(A)3.6(l)4.8(e)-27.3(\004)6.3(a)-0.8(n)-0.6(d)-0.9(e)-1.7(r)]TJ /Span<>> BDC ( )Tj EMC 5.344 0 Td [(M)5.4(.)]TJ /Span<>> BDC ( )Tj EMC 2.401 0 Td [(L)-3.6(u)4.6(k)-18.5(i)5.9(a)-0.7(n)1.9(o)-0.6(v)33.6(, )0.5(D)-2(m)5.9(i)0.9(t)-5.4(r)-40.2(y)]TJ /Span<>> BDC ( )Tj EMC 9.249 0 Td [(O)13.1(.)]TJ /Span<>> BDC ( )Tj EMC 2.282 0 Td [(K)10.9(i)11(s)4.9(e)-1.9(l)4.9(e)-4(v)33.5(, )]TJ 0 Tw -19.277 -1.218 Td [(M)10.5(i)7.9(k)5.3(h)4.8(a)-2(i)7.4(l)]TJ /Span<>> BDC ( )Tj EMC [(A)-12.5(.)]TJ /Span<>> BDC ( )Tj EMC [(A)2.8(ga)-0.8(p)-4.9(o)-0.6(v)]TJ /T1_0 1 Tf -0.047 Tw 0 -1.218 TD [(C)-6.5(o)-5.8(l)-19(l)-14.3(e)-9.4(c)-32.5(t)-37.4(i)3.2(o)0.9(n a)2.4(n)-4.6(d p)-3.8(r)-6(o)-7(ce)-13.3(s)-12.8(s)-16.5(i)7.1(n)-1.9(g o)-2.2(f m)1.8(a)-8.4(t)-15.2(e)-2(r)-48(i)5.1(a)-1.5(l)-22.5(:)]TJ /T1_3 1 Tf [( D)-2(m)5.8(i)0.9(t)-5.4(r)-40.2(y)]TJ /Span<>> BDC ( )Tj EMC [(O)13.1(.)]TJ /Span<>> BDC ( )Tj EMC [(K)10.9(i)11(s)5(e)-2(l)4.9(e)-4(v)33.6(, )]TJ 0 Tw T* [(D)-3.2(a)-0.8(n)6.2(i)3.4(i)7.4(l)]TJ /Span<>> BDC ( )Tj EMC [(R)-2.4(.)]TJ /Span<>> BDC ( )Tj EMC [(M)5.2(ar)-2.5(k)15.8(ar)-40.2(y)3.8(a)-0.8(n)-6(, A)3.6(l)4.8(e)-27.3(\004)6.3(a)-0.8(n)-0.6(d)-0.9(e)-1.7(r)]TJ /Span<>> BDC ( )Tj EMC [(M)5.4(.)]TJ /Span<>> BDC ( )Tj EMC [(L)-3.6(u)4.6(k)-18.5(i)6(a)-0.8(n)1.9(o)-0.6(v)]TJ /T1_0 1 Tf -0.007 Tc 0.961 Tw 0 -1.218 TD [(St)-34.7(a)-15.4(t)-44.4(i)-4.3(s)-27(t)-44.4(i)-1.8(c)-18.8(a)-8.5(l)-7( p)-10.8(r)-13(o)-14(c)-6.8(e)-20.3(s)-19.8(s)-23.5(in)-8.9(g)2(:)]TJ /T1_3 1 Tf 0.001 Tc 0.953 Tw 10.042 0 Td [( A)4.6(l)5.8(e)-26.2(\004)7.3(ande)-0.7(r)]TJ /Span<>> BDC 5.068 0 Td ( )Tj EMC [(M)6.4(.)]TJ /Span<>> BDC 2.125 0 Td ( )Tj EMC [(L)-2.6(u)5.7(k)-17.5(i)6.9(an)2.9(ov)34.7(,)1( )]TJ 0 Tc 0 Tw -17.235 -1.218 Td [(D)-3.2(a)-0.8(n)6.2(i)3.4(i)7.4(l)]TJ /Span<>> BDC ( )Tj EMC [(R)-2.4(.)]TJ /Span<>> BDC ( )Tj EMC [(M)5.2(ar)-2.5(k)15.8(ar)-40.2(y)3.8(a)-0.8(n)]TJ /T1_0 1 Tf -0.101 Tw 0 -1.218 TD [(W)3.1(r)-48(i)-6(t)-37.4(i)7.1(n)-1.9(g o)-2.2(f t)-16.7(h)-5.3(e t)-15.2(e)-23.9(x)-36(t)-20.1(:)]TJ /T1_3 1 Tf [( D)-3.1(a)-0.8(n)6.2(i)3.4(i)7.4(l)]TJ /Span<>> BDC ( )Tj EMC [(R)-2.5(.)]TJ /Span<>> BDC ( )Tj EMC [(M)5.2(ar)-2.5(k)15.8(ar)-40.2(y)3.8(a)-0.8(n)-5.9(, D)-2(m)5.8(i)0.9(t)-5.4(r)-40.2(y)]TJ /Span<>> BDC ( )Tj EMC [(O)13.1(.)]TJ /Span<>> BDC ( )Tj EMC [(K)10.9(i)11(s)5(e)-2(l)4.9(e)-4(v)33.6(, )]TJ 0.001 Tc -0.001 Tw 0 -1.218 TD [(A)4.6(l)5.8(e)-26.3(\004)7.3(ande)-0.7(r)]TJ /Span<>> BDC 3.882 0 Td ( )Tj EMC [(M)6.4(.)]TJ /Span<>> BDC 1.172 0 Td ( )Tj EMC [(L)-2.6(u)5.6(k)-17.4(i)6.9(an)2.9(ov)]TJ /T1_0 1 Tf 0.006 Tc -0.006 Tw -5.053 -1.218 Td [(E)11.6(dit)-31.4(i)13.1(n)4.1(g)15(:)]TJ /T1_3 1 Tf 0 Tc 0.628 Tw 3.238 0 Td [( D)-3.2(a)-0.8(n)6.2(i)3.4(i)7.4(l)]TJ /Span<>> BDC ( )Tj EMC [(R)-2.5(.)]TJ /Span<>> BDC ( )Tj EMC [(M)5.3(ar)-2.5(k)15.8(ar)-40.2(y)3.8(a)-0.8(n)-6(, D)-2(m)5.8(i)1(t)-5.4(r)-40.2(y)]TJ /Span<>> BDC ( )Tj EMC [(O)13.1(.)]TJ /Span<>> BDC ( )Tj EMC [(K)10.9(i)11(s)4.9(e)-1.9(l)4.8(e)-4(v)33.6(, )]TJ 0 Tw -3.238 -1.218 Td [(M)10.5(i)7.9(k)5.3(h)4.8(a)-2(i)7.4(l)]TJ /Span<>> BDC ( )Tj EMC [(A)-12.5(.)]TJ /Span<>> BDC ( )Tj EMC [(A)2.8(ga)-0.8(p)-4.9(o)-0.6(v)]TJ /T1_2 1 Tf 0.023 Tw 0 -2.436 TD (\255\026\036\031\036\025\034\224 \017\225 \032\026\020\017\022\032\221 \(\ ORCID\))Tj /T1_0 1 Tf 0.391 Tw 0 -1.218 TD (\204\026\030\022\026\030\034\016\027 \212\026\027\017\017\035 \217\026\235\ \026\220\035\036\r\017\004)Tj /Span<>> BDC ( )Tj EMC (\227 \022.\n.\027., \007\024\006\036\027\021 )Tj 0.192 Tw 0 -1.218 TD (\022\026\235\036\007\030\t \b\017\030\031\030\020\017\017 \205\205\204 \204\ \206\211 \017\n. \204.\200.)Tj /Span<>> BDC ( )Tj EMC (\214\024\n\024\027\024\f\024\r\026; )Tj 0 Tw 0 -1.218 TD (ORCID 0000-0003-2711-2400)Tj 0.194 Tw 0 -1.218 TD (\214\031\022\034\016\027\024\r \202\035\036\022\f\026\027\007\030 \204\026\ \022\f\017\n\024\r\017\004)Tj /Span<>> BDC ( )Tj EMC (\227 \024\030\007\017\027\026\021\024\030 \022\026)Tj 0 Tw (-)Tj 0.346 Tw 0 -1.218 TD (\235\036\007\030\t \b\017\030\031\030\020\017\017 \205\205\204 \204\206\211\ \017\n. \204.\200.)Tj /Span<>> BDC ( )Tj EMC (\214\024\n\024\027\024\f\024\r\026; )Tj 0 Tw 0 -1.218 TD (ORCID 0000-0002-2768-4305)Tj 0.193 Tw 0 -1.218 TD (\025\017\f\036\035\036\r \212\n\017\021\030\017\005 \210\035\036\020\024\ \r\017\004)Tj /Span<>> BDC ( )Tj EMC (\227 \022.\n.\027., \205\206\207\211 \253\203\204\222\037 )Tj 0.482 Tw 0 -1.218 TD (\022\024\035\024\023\030\024\022\021\024\035\024\020\017\017 \017\n\036\027\ \017 \202.\203.)Tj /Span<>> BDC ( )Tj EMC (\217\t\032\017\b\273 \204\017\027\007\030\026\r\026 )Tj 0 Tw T* (\217\024\f\f\017\017; ORCID 0000-0001-8332-7540)Tj 0.693 Tw 0 -1.218 TD (\202\020\026\023\024\r \204\017\b\026\017\035 \202\027\007\030\036\036\r\ \017\004)Tj /Span<>> BDC ( )Tj EMC (\227 \007.\n.\027., \023\030\024\235\036\f)Tj 0 Tw (-)Tj 0.362 Tw 0 -1.218 TD (\f\024\030, \023\030\024\235\036\f\f\024\030 \022\026\235\036\007\030\t \ \b\017\030\031\030\020\017\017 \205\205\204 \204\206\211 \017\n. )Tj 0 Tw 0 -1.218 TD (\204.\200.)Tj /Span<>> BDC ( )Tj EMC (\214\024\n\024\027\024\f\024\r\026; ORCID 0000-0002-6569-7078)Tj /T1_2 1 Tf 0.023 Tw 0 -2.436 TD (INFORMATION ABOUT THE AUTHORS \(ORCID\))Tj /T1_0 1 Tf 0 Tw 0 -1.218 TD [(Dani)-16(il R. Mar)-23.9(k)-17(ar)-23.9(y)22(an)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0003-2711-2400)Tj 0 -1.218 TD [(Alek)-10(sandr M. L)35.1(uk)-16(ianov)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0001-8332-7540)Tj 0 -1.218 TD [(Dmi)-24(tr)-23.9(y)]TJ /Span<>> BDC ( )Tj EMC (O.)Tj /Span<>> BDC ( )Tj EMC (Kiselev)Tj /Span<>> BDC ( )Tj EMC (\227 0000-0001-8332-7540)Tj 0 -1.218 TD (Mikhail)Tj /Span<>> BDC ( )Tj EMC (A.)Tj /Span<>> BDC ( )Tj EMC [(A)-24.9(gapov)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0002-6569-7078)Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\033\030\031\030\213\b)-20.9(\035\231\213\233\t \021\032)50(\b)42(\032\231\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj -51.938 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 23, \023\0221)69(, 202)69(4)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 23, \023\0221)69(, 202)69(4)]TJ /T1_5 1 Tf 25 0 0 25 28.1276 56.0378 Tm (80)Tj ET endstream endobj 1814 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\034\002\025\202\001\025)21(\222 \006)-10(\026)11(\016\221\016\001\220 \221\025\r\002\016\217)-20.9(\201\016\001\220\203 \026)11(\013\222\025\r\025\202)10.1(\025 \201\001\013 \r\022\007\016\017\016\001\220\220 )]TJ 0 -1 TD [(\221\025\006)-10(\026)-31(\026\002\013\r\024\013\026\220\017\016\006\n)10(\025\202)10(\025 \013\001\013\007\216\001\025\202)10(\025 \001\016\201\016\002\217\013\001\220\205)]TJ 42.45 1 Td [(Pr)20(ognoses of injur)-30.9(y scale in sur)31(gical tr)31(eatment )]TJ 4.112 -1 Td [(of post-tr)21(aumatic anal incontinence)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0.004 Tc 0.049 Tw 10 0 0 10 42.5197 396.0239 Tm [(\023\030\036\007\024\023\036\030\026\006\017\024\027\027\024\005 \031\035\ \034\021\030\026\r\031\022\024\r\024\005 \007\017\026\020\027\024\f\021\ \017\022\017 \007\035\016)4( )]TJ 0.114 Tw 0 -1.218 TD (\024\006\036\027\022\017 \030\036\031\035\034\021\026\021\024\r \b\017\030\ \031\030\020\017\004\036\f\022\024\020\024 \035\036\004\036\027\017\016 \ \023\024\f\035\036)Tj 0 Tc 0 Tw (-)Tj 0.004 Tc 0.422 Tw T* [(\030\024\007\024\r\024\005 )0.5(\026\027\026\035\034\027\024\005 )0.5(\017\027\022\024\027\021\017\027\036\027\006\017\017. )0.5(\215\024\022\026\026\021\036\035\034\027\024,)3.9( )]TJ 0.253 Tw T* [(\004\021\024 \b\017\030\031\030\020\017\004\036\f\022\024\036 \035\036\004\ \036\027\017\036 \027\026\004\017\021\036\035\034\027\024 \031\035\031\004\ \001\017\035\024)4( )]TJ 0.128 Tw T* (\235\031\027\022\006\017\024\027\026\035\034\027\024\036 \f\024\f\021\024\ \016\027\017\036 \017)Tj /Span<>> BDC ( )Tj EMC (\022\026\004\036\f\021\r\024 \032\017\027\017 \031)Tj /Span<>> BDC ( )Tj EMC (\023\026)Tj 0 Tc 0 Tw (-)Tj 0.004 Tc 0.325 Tw T* (\006\017\036\027\021\024\022, \023\030\017\027\016\r\001\017\b \031\004\026\ \f\021\017\036 \r)Tj /Span<>> BDC ( )Tj EMC [(\017\f\f\035\036\007\024\r\026\027\017\017, \004\021\024)4( )]TJ 0.655 Tw T* [(\023\024\007\021\r\036\030\032\007\026\036\021\f\016 )0.6(\007\017\027\026\n\017\022\024\005 )0.5(\023\024\022\026\026\021\036\035\036\005 )0.5(W)22(e)-18(xner)4( )]TJ 0.015 Tw T* [(Incont)-32(inence S)-24(cor)-24(e, FIQL \017)]TJ /Span<>> BDC ( )Tj EMC (PISQ-12. \210\007\027\026\022\024 \022\024\030\030\036\035\016)Tj 0 Tc 0 Tw (-)Tj 0.004 Tc -0.009 Tw T* (\006\017\024\027\027\t\036 \r\026\017\n\024\f\r\016\017 \n\036\032\007\ \031 \023\024\022\026\026\021\036\035\016\n\017 \023\030\036\007\024\023\ \036)Tj 0 Tc 0 Tw (-)Tj 0.004 Tc 0.24 Tw T* (\030\026\006\017\024\027\027\024\005 \031\035\034\021\030\026\r\031\022\ \024\r\024\005 \007\017\026\020\027\024\f\021\017\022\017 \017)Tj /Span<>> BDC ( )Tj EMC (\017\n\036\027\036)Tj 0 Tc 0 Tw (-)Tj 0.004 Tc 0.088 Tw T* [(\027\017\016\n\017 \030\036\031\035\034\021\026\021\024\r \024\006\036\027\ \024\004\027\t\b \001\022\026\035 \024\022\026\026\035\017\f\034 \035\017\ \002\024)4( )]TJ -0.035 Tw T* [(\f\021\026\021\017\f\021\017\004\036\f\022\017 )0.5(\027\036\027\026\004\017\n\t\n\017, )0.5(\035\017\002\024 )0.5(\017\n\036\035\017 )0.5(\n\026\035\031\033 )0.5(\f\017\035\031,)4( )]TJ 0.149 Tw T* (\004\021\024 \027\036 \023\024\r\024\035\016\036\021 \r\024\f\023\030\017\ \027\017\n\026\021\034 \017\b \r)Tj /Span<>> BDC ( )Tj EMC (\022\026\004\036\f\021\r\036 \023\030\024)Tj 0 Tc 0 Tw (-)Tj 0.004 Tc 0.048 Tw T* [(\020\027\024\f\021\017\004\036\f\022\017\b. \230\026\022\017\n \024\002\030\ \026\024\n, \n\024\032\027\024 \023\030\036\007\023\024\035\024\032\017\ \021\034,)4( )]TJ 0.231 Tw T* (\004\021\024, \027\036\f\n\024\021\030\016 \027\026)Tj /Span<>> BDC ( )Tj EMC [(\023\036\030\r\024\f\021\036\023\036\027\027\031\033 \r\026\032\027\024\f\ \021\034 \224\217\211\003\222)4( )]TJ 0.243 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\023\030\036\007\024\023\036\030\026\006\017\024\027\027\024\005 \007\017\ \026\020\027\024\f\021\017\022\036 \017)Tj /Span<>> BDC ( )Tj EMC [(\023\035\026\027\017\030\024\r\026\027\017\017)4( )]TJ 0.05 Tw T* (\b\017\030\031\030\020\017\004\036\f\022\024\020\024 \035\036\004\036\027\ \017\016 \202\230\215, \220\235\235\036\022\021\017\r\027\024\f\021\034 \ \b\017\030\031\030)Tj 0 Tc 0 Tw (-)Tj 0.004 Tc 0.088 Tw T* [(\020\017\004\036\f\022\024\020\024 \035\036\004\036\027\017\016 \027\036\ \026\r\017\f\017\021 \024\021 \r\036\035\017\004\017\027\t \007\036\235\ \036\022\021\026)4( )]TJ 0.185 Tw T* (\r\027\031\021\030\036\027\027\036\020\024 \017\035\017 \027\026\030\031\ \032\027\024\020\024 \f\235\017\027\022\021\036\030\024\r, \030\036\020\017\ \f\021\030\017)Tj 0 Tc 0 Tw (-)Tj 0.004 Tc 0.107 Tw T* (\030\031\036\n\t\b \027\026)Tj /Span<>> BDC ( )Tj EMC (\224\217\211\003\222, \026)Tj /Span<>> BDC ( )Tj EMC [(\021\026\022\032\036 \024\021 \021\026\022\017\b \023\026\030\026\n\036\021\ \030\024\r, \022\026\022)4( )]TJ -0.04 Tw T* (\021\024\035\013\017\027\026 \035\036\r\024\005 \017)Tj /Span<>> BDC ( )Tj EMC [(\023\030\026\r\024\005 \027\024\032\036\022 m. lev)-15(a)15(t)17(or ani, \026)]TJ /Span<>> BDC ( )Tj EMC [(\021\026\022\032\036)4( )]TJ -0.081 Tw T* [(\031\020\024\035 )0.5(\017\b )0.5(\r\023\035\036\021\036\027\017\016 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 8.177 0 Td [(\023\030\024\007\024\035\034\027\031\033 )0.5(\n\t\001\006\031 )0.5(\026\027\026\035\034\027\024\020\024 )0.5(\022\026)]TJ 0 Tc 0 Tw (-)Tj 0.004 Tc 0.043 Tw -8.177 -1.218 Td (\027\026\035\026, \026\027\024\030\036\022\021\026\035\034\027\t\005 \031\ \020\024\035 \r)Tj /Span<>> BDC ( )Tj EMC (\023\024\022\024\036, \023\030\017)Tj /Span<>> BDC ( )Tj EMC [(\027\026\021\031\032\017\r\026\027\017\017)4( )]TJ 0.334 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC [(\f\032\026\021\017\017, \026\n\023\035\017\021\031\007\026 \f\024\022\030\ \026\013\036\027\017\016 \023\031\002\024\030\036\022\021\026\035\034\027\ \024\005)4( )]TJ 0.2 Tw T* (\n\t\001\006\t, \027\026\035\017\004\017\036 \030\036\022\021\024\006\036\ \035\036 \017)Tj /Span<>> BDC ( )Tj EMC [(\017\027\r\026\020\017\027\026\006\017\017 \023\030\016\n\024\005)4( )]TJ 0.124 Tw T* [(\022\017\001\022\017. )0.5(\210\007\027\026\022\024 )0.5(\235\031\027\022\006\017\024\027\026\035\034\027\t\036 )0.5(\023\030\024\002\t )0.5(\027\036 )0.5(\r\t\016\r\017\035\017)4( )]TJ 0.169 Tw T* (\031)Tj /Span<>> BDC ( )Tj EMC [(\007\026\027\027\t\b \023\026\006\017\036\027\021\024\022 \024\023\031\013\ \036\027\017\016 \n\t\001\006 \021\026\024\r\024\020\024 \007\027\026,)4( )]TJ 0.121 Tw 23.244 31.663 Td (\004\021\024, \023\024)Tj /Span<>> BDC ( )Tj EMC (\r\f\036\005 \r\017\007\017\n\024\f\021\017, \024\002\031\f\035\024\r\035\ \036\027\024 \n\024\035\024\007\t\n \r\024)Tj 0 Tc 0 Tw (-)Tj 0.004 Tc 0.038 Tw T* (\030\026\f\021\024\n \007\026\027\027\024\005 \020\030\031\023\023\t. \214\ \017\001\034 \027\036\022\024\021\024\030\t\036 \026\f\023\036\022\021\t\ \022\026)Tj 0 Tc 0 Tw (-)Tj 0.004 Tc -0.017 Tw T* [(\004\036\f\021\r\026 \032\017\027\017, \021\026\022\017\036 \022\026\022\ \022\026\004\036\f\021\r\024 \f\036\022\f\031\026\035\034\027\024\005 \032\ \017\027\017)4( )]TJ 0.049 Tw T* [(\023\024\f\035\036 \b\017\030\031\030\020\017\004\036\f\022\024\020\024 \ \035\036\004\036\027\017\016 \023\030\024\007\036\n\024\027\f\021\030\017\ \030\024\r\026\035\017)4( )]TJ 0.2 Tw T* (\023\030\016\n\031\033 \f\r\016\034 \f)Tj /Span<>> BDC ( )Tj EMC [(\220\b\024\020\030\026\235\017\004\036\f\022\017\n\017 \017\n\036\027\036\ \027\017\016\n\017 m.)4( )]TJ 0 Tw T* [(lev)-15(a)15(t)17(or ani.)]TJ 0.008 Tc 0.532 Tw T* (\200 \017\f\f\035\036\007\024\r\026\027\017\017, \024\023\031\002\035\017\ \022\024\r\026\027\027\024\n \r)Tj /Span<>> BDC ( )Tj EMC [(2021 \020\024\007\031,)8( )]TJ 0.28 Tw T* [(Cl)-16(aes)]TJ /Span<>> BDC ( )Tj EMC (Ignell \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021\024\030\t [13] \021\026\022\032\036 \026\027\026\035\017\ \017\030\024\r\026)Tj 0 Tc 0 Tw (-)Tj 0.008 Tc 0.211 Tw T* [(\035\017 )0.5(\r\026\017\n\024\f\r\016\034 )0.5(\n\036\032\007\031 )0.5(\f\021\036\023\036\027\034\033 \202\230\215, )0.5(\f\017\n\023\021\024\n\026\n\017)8( )]TJ 0.462 Tw T* (\026\027\026\035\034\027\024\005 \017\027\022\024\027\021\017\027\036\027\ \006\017\017 \017)Tj /Span<>> BDC ( )Tj EMC (\023\024\022\026\026\021\036\035\016\n\017, \023\024\035\031)Tj 0 Tc 0 Tw (-)Tj 0.008 Tc 0.251 Tw T* (\004\026\036\n\t\n\017 \r)Tj /Span<>> BDC ( )Tj EMC (\b\024\007\036 \224\217\211\003\222 \017)Tj /Span<>> BDC ( )Tj EMC (\230\215\211\003\222. \200)Tj /Span<>> BDC ( )Tj EMC [(\017\f\f\035\036\007\024\r\026\027\017\036)8( )]TJ 0.156 Tw T* (\r\024\001\035\017 \023\026\006\017\036\027\021\022\017 \f)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\r\017\004\027\024\005 \b\017\030\031\030\020\017\004\036\f\022\ \024\005 \023\035\026)Tj 0 Tc 0 Tw (-)Tj 0.008 Tc 0.316 Tw T* [(\f\021\017\022\024\005 \202\230\215 \027\036\023\024\f\030\036\007\f\021\ \r\036\027\027\024 \023\024\f\035\036 \036\f\021\036\f\021\r\036\027\027\ \t\b)8( )]TJ 0.188 Tw T* [(\030\024\007\024\r, \r\t\023\024\035\027\036\027\027\024\005 \r\030\026\004\ \024\n-\023\030\024\022\021\024\035\024\020\024\n. \223\036\030\036 6)8( )]TJ 0.27 Tw T* (\n\036\f\016\006\036\r \023\024\f\035\036 \023\036\030\r\017\004\027\024\ \005 \f\235\017\027\022\021\036\030\024\023\035\026\f\021\017\022\017 \023\ \026)Tj 0 Tc 0 Tw (-)Tj 0.008 Tc 0.072 Tw T* [(\006\017\036\027\021\022\026\n \023\030\036\007\035\026\020\026\035\024\f\ \034 \026\023\024\035\027\017\021\034 \024\023\030\024\f\027\017\022 W)22(e)-18(xner)8( )]TJ 0.048 Tw T* [(Incont)-32(inence S)-24(cor)-24(e \017)]TJ /Span<>> BDC ( )Tj EMC (\023\024\r\021\024\030\027\024 \023\030\024\005\021\017 \031\035\034\021\ \030\026\r\031\022\024)Tj 0 Tc 0 Tw (-)Tj 0.008 Tc 0.081 Tw T* (\r\024\036 \017\f\f\035\036\007\024\r\026\027\017\036 \027\026)Tj /Span<>> BDC ( )Tj EMC [(\023\030\036\007\n\036\021 \024\f\021\026\021\024\004\027\t\b \007\036\235\ \036\022\021\024\r)8( )]TJ 0.316 Tw T* [(\f\235\017\027\022\021\036\030\027\024\020\024 )0.5(\022\024\n\023\035\036\022\f\026. )0.5(\215\024\035\031\004\036\027\027\t\036 )0.5(\030\036\031\035\034\021\026\021\t)8( )]TJ 0.247 Tw T* [(\023\024\r\024\035\017\035\017 \026\r\021\024\030\026\n \017\f\f\035\036\ \007\024\r\026\027\017\016 \f\007\036\035\026\021\034 \r\t\r\024\007\t)8( )]TJ -0.015 Tw T* (\024)Tj /Span<>> BDC ( )Tj EMC (\027\026\035\017\004\017\017 \f\021\026\021\017\f\021\017\004\036\f\022\017\ \027\026\004\017\n\024\005 \f\r\016\017 \n\036\032\007\031 \f\021\036\ )Tj 0 Tc 0 Tw (-)Tj 0.008 Tc -0.055 Tw T* (\023\036\027\034\033 \023\024\f\035\036\030\024\007\024\r\024\005 \021\030\ \026\r\n\t \023\030\024\n\036\032\027\024\f\021\016\n\017 \017)Tj /Span<>> BDC ( )Tj EMC (\023\024\022\026)Tj 0 Tc 0 Tw (-)Tj 0.008 Tc 0.049 Tw T* (\026\021\036\035\016\n\017 \230\215\211\003\222 \(\020\035\031\002\017\027\ \026, \007\035\017\027\026 \017)Tj /Span<>> BDC ( )Tj EMC [(\031\020\024\035 \024\f\021\026\021\024\004\027\024\020\024)8( )]TJ 0.081 Tw T* (\007\036\235\036\022\021\026\) \017)Tj /Span<>> BDC ( )Tj EMC (\224\217\211\003\222 \(\020\035\031\002\017\027\026, \007\035\017\027\026\ \017)Tj /Span<>> BDC ( )Tj EMC [(\031\020\024\035 \007\036\235\036\022\021\026\).)8( )]TJ 0.048 Tw T* (\025\030\024\n\036 \021\024\020\024, \f\021\026\021\017\f\021\017\004\036\ \f\022\017 \027\026\004\017\n\024\005 \024\022\026\026\035\026\f\034 \022\ \024\030)Tj 0 Tc 0 Tw (-)Tj 0.008 Tc 0.213 Tw T* [(\030\036\035\016\006\017\016 \n\036\032\007\031 \r\t\030\026\032\036\027\ \027\024\f\021\034\033 \027\036\007\036\030\032\026\027\017\016 \020\026\ \024\r)8( )]TJ 0.012 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC [(\f\021\031\035\026 \(\f\024\020\035\026\f\027\024 \001\022\026\035\036 W\ )22(e)-18(xner Incont)-32(inence S)-24(cor)-24(e\))8( )]TJ 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0 Tc 0 Tw 9 0 0 9 42.5197 730.483 Tm (\020\004\206\f\t\204\004 3.)Tj 0 0 0 1 k /GS1 gs /T1_3 1 Tf ( \221\021\026\006\031\021\025\002 P \030\023\002 \013\n\r\f\f\025\203\025\ \031\021\024\n\027 \013\n\032\032\031\023\002\203\025\025)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0 -1.2 TD [(T)48(able 3.)]TJ 0 0 0 1 k /GS1 gs /T1_3 1 Tf [( P)16(-v)16(alues for cor)-15.8(relation coef\233cients)]TJ ET q 42.52 428.18 453.543 281 re W n q /GS0 gs 453.543294 0 0 281.0048738 42.5196838 428.1741424 cm /Im0 Do Q Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\033\030\031\030\213\b)-20.9(\035\231\213\233\t \021\032)50(\b)42(\032\231\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj /T1_4 1 Tf 25 0 0 25 512.9018 56.0378 Tm (79)Tj ET endstream endobj 1815 0 obj <>stream Adobed     '$''''$25552;;;;;;;;;;   %%#(((((#,0000,7;;;7;;;;;;;;;;   %%#(((((#,0000,7;;;7;;;;;;;;;;   %%#(((((#,0000,7;;;7;;;;;;;;;;<J""  KQQ !"#$%&'()*123456789:ABCDEFGHIJRSTUVWXYZabcdefghijqrstuvwxyzX!1AQa"q2D$BTrR#b %&'()*3456789:CEFGHIJSUVWXYZcdefghijstuvwxyz?"H'H-$@[b b nي~يDE`f(~R `f(~R IH'H-$@[b b nي~يDE`f(~R `f(~R IH'H-$@] -׭; nǴL."c7U?2/\#{ΟF{9Aa-vc".F> r7؍?:uWa[}*x3QT{˶i8JP?TvE]q~7;]K~oy#}yJ1&+$,ʃ=ew60oi4EKoyՔG:OμNuLaU){TkvjE/aKR6 \'d1h_~t%b7\j-f&cٰu^LIxEKoy#}\ rը)j;akEW4C cR6b\R aq$P.EO\#{ζZ%j~~4+OhRXRZ y =E/\#{ΟFJ-5Bx" f7JޓQ"LRǙ]K~oy"|"i}P$J-&6lgݬ;. C TlC"[p>Yӡ|3sIk'A h߂\#{ΟFxj0+^ G}Cl&b{ĊWeᦅVTpoF]Koy"[A/V10"l̀vH cbim9H8F#eh|o~t%ȿb7=VŷS<[\[ڴX6C1io~t%b7k2VkU免dlŕ)`bGbZƙ>;1%nDkXFAC"i9KWNs0x4Rq ƅyF> r7؍?:W굪aW4I+^g{ŚVhUmGs#jo`1$Gj"#}.ET2{D*Ics[pl\/GoQ½yژ1[0\'4EK~oy">UsDI-{-=@sXÅ".EO\#{Ϋ=[Iu9ͦ'" Ɖ𕄴6p8wTqڰs@;LEg.ES"Gd{?F> r7؍?:חѫJ1yӣէQvQvea*ZkQ٨汜 7`-yYK~oy#})SĶ7@c3oN"OA{Z흖F> r7؍?:+Rs]Kq5?ou)Nڵws$*Ktx /K#}.FUSQTVJu*6eG1̂S*W{MjO,LqsaEg.FO\#{άѾ*TsqXƓЩQMae*;.K1ր" mw6I:C"0ș=jԦ\ _\#{ΟFhR]j;g NK} {LujR.L@w`@[F> r/؍?:,:vڅDQhB/隘~nZڛ{Nڧ$w@Y%ȿb7K~oyֻ=(mW3ZXdlÉt^|Kف}z͓mA9 @ZF> r7؍?:R&ժRӰTyʏ /P r/؍?:Cylmg΀|%?`mC\L8 ހWEkF OΡKoyyMnf" sI'6]j+bm9!4m|o~t%ȿb7ONNPSu&TU1[&]t# LYE|o~t%b7v7Z U"IGj<JGԭUQ̦uưS%IKoy#}pUFS0[Mƙ{̓[x;#mJ/vv_FL!Ȝw6K3 J8JoC LH,Y5f] wLj`98rԙ" r/؍?:|_~uck n,6\u.uܫSf0<͖D,. EK~oy"an:U6B8ߥU^ȉ`˼?F> r/؍?:/H?3MwUa$30FiJn9k ;v4_"#}.FR}Syu>vTm*mIbWs+XaR=R@U@qxn<  r7؍)KoyjRw% Rj gmJ-. !+; 딩+Us٨v "ډ@Uo~u&z#ȥ#`Z]R+ڵ[(`mW.-B&:CM@*47gj'J">r؍|+o;] Ъ"/OݿO Ⱦ?v>؃/"OC}tȟb΀,?Ao"}>:"/OݿO Ⱦ?v>'؃/"OC}tȟb΀,?Ao!>:"/?ݿO uS+苝7?]56؆\);΀a):PKc9~)<5cP?:"5\-*΢M, oyFҫVvLơ~tEPt*µm89 iD v*_浴FPcy\OcP?:~)<5. -}W}X:Co;rn YH9Ĺv8ܕ_'>ơ~u1/qգI*>X ",%*5+U`;u/" $rIB~u'>ơ~tE޻0Ŕݺn\YRj KpV}6\TJ*h3Iw?Pqa_WDQ{M^x6!lUX4Sk i-kr5)<5cP?:"r6k:]9>pk]`,G$a1A¨q)y@\cP?:~)<5."`5͇08S]}+Y~ˁ5] RyCjO'>ơ~tE 4aF.72dԙO +kO(]F~CZ<2_'>ơ~tEZ:50ުM-3ܕAQΪ‘M-v2'>ơ~tRyCj@]'WkʵhmLɧazM{tcP?:~)<5.$̚ڭZAKOԱ6IjsYIw?PqaW#CX?\-QP?X6y4C3, ;ΟO(}CU=}EkVIkA S\f ɸТc(o'>ơ~tEWz4"LU [Q NM-p?O(}C;΀lO Ю׵jk͵ڙl03hҬT))<5cP?:"O! 6-s8ڎ xm;3 Hr> M/ifM9hvw\'cP?:~)<5. E{3mA8Se6`{SIw?Pq_SNM­WǶW8f@+, ͗Ty{'>ơ~u=3k)ԡIPZ%̈`6{.:# 0y͘3kG(}C;΀Fas3f)%,Ȫ\ *LHyfFu\GcP?:~)<5/cRe7l ~J,nJVeFEG<KRyCjO'>ơ~tEJXFӤNV_2j/t*;y{;#hC+~)<5cP?:"+FQqPR*yhSrf<}6i74'>ơ~tRyCj@_@ɴiUm]짰ݷfR<괝KoeԪuPqIw}D7b60H'!G(5+^ ڂ8x?O(}Cơ~tRyCj@]'r*Xv NsE\{[!<>EH;k gm&.Iw?Pq{O浮y>Un< 8[L7 7uIw?Pqg~%M:i>mULIhnEF*uGUaڎq8F˜;ΧOGj'/Vn1:ma3mqeJTcCuSP=!yK]\ߤޚc9_Ft/eIwv˪WR`6ݵPECn^#hu#RV3V{9/)<5cP?:"3y3l$asɨr9SX3\cP?:~)<5.ɘz曆nE曃#N 46*Q.s0u;PqIww' Unyks]5 znD=gR_;νޘ\\SAq^g݆4FvlW ;ΟO(}CɔkVѪ]BKFAњ>H$5{.hrPqIwwǒpS•'Sh.$l;0wGֵZ)cjVsܶA.Iw?Pqѫib_I&:QޡSBgV{vFK '>ơ~tRyCj@]pj J`bBHʅVs&Usimv2\cP?:~)<5.rVu溧8.Oɔ؞zJns.vgc%'>ơ~u>c6z-mji-@q]}Ia!Ѫ"KJUqLÊ_][Wi;l1ؽNP7p$Sa03 NbpibRCA5f!Ĝƈ[m_=w+Qo(7Loi69aq~!s)|.tBxnRqfrۻlWjfõ}L N@r{3Wu1]mzZ3UR<}>Puzs_ @  1. s\w䳶 1r%7YvmJp "FAx>R*T |ReAJYXL"Fpnr{m0_=9GW N&]9K 1qUs98r2',/ml)W(kk~/miRm1I3x5!v&2dm>O /m-$lL6\9J:{Y,=sRu0iU4[Fث͇ 7 -7hW)5BVL4z |;`ZL%cy U1 ,P5hpڨ !oO&aisF dln> Sm&&4Va1,P]mF "`ƫQ" hƚo? uz%A+:B)S$\w$ @Re+>?̺~E|yl`WAQ' 5=or&QS_ XסQfәfmy([l!{5"L3w azx;Ri`ɼtE"YX*5A1C.1C'Ry*q[͐SCI.M"_ _!S;8kQ{kZs;@ke+\4TWk>h *۾TEɜs:CJmxnӃrDր^/1mxkZ H;;Mz%ruFu}WiAlY HE"ӭCMUّ!okDrSN,Wiu*j q"P%41 m[dd5;g@/v)c^(Eiٍ"ӷ_m(zX#}a Ю!܊]nfw9v9Nўq@^"/KĚΡ^LDHiuZu15j}64\[ VTmZ F1'*rg'1+C\׻Yv9@^.'B6zE]ԋ- /$KSk]i<@_z"= 1 mWr/_Eʠ"" "-C(4.O`[\ɴ_TenöaO"{zJm(2z-z=J7ZF(mN)̺tsh'%`8f*4Z$A=\Y'AYL>no /u~n#V0>Z&DmѪ}ɜ* rUbr(9,{Tq[XЦj6mQHy@^:/[ȵ82c.֗g։$@VX;R&Ue&m"S ODq@\/`(n]ٷM&-ey'_v&21k;"]i3"{9CG;5k0쑲69)R!/. =@[t97{W]+S4}StPH @DECcpFb[DǷ>ֱErG'9@U5iWq0`h%K [YlK֢DZ]6]&NVE*6)VZP.m v6d v)iYsy .mJ߶k6MžJwBsvÝq '$ 8 m5]o@^ÿ0uzql;o# @DD@DD@DE?)?[h ƁoG'GϵB"Q{laQeh 5l%Z؊ L\| /Ev\F{$Q{Mnf1T`벥@Z 8rFNMa񴪌;*D>&wɄEUmu:.c9"/U;G X@,B ?S UM[#j?y[ s:/l\H;N'YcQhc64b=пVRܛRjT PǣLhx)90$IF`=+N]"X <ٱ9]b""""j4JCiȎ+4鲓0֌e+>?̺~E|ynf%!{x^0EIԪb(Pu:| ~Z3q(jܫԤ~@ 4ZeȺ>¿:8uW5L.&SG\rHRU;WX/N:#ۯ/:$3":MWϗ_ *۾TE=LQ6K\ @u/!GZ$Zt3Ҥi"NB&q8NP֩m\=2?!Ѣ5o+DEr_XJsqx^t: a@hKfSs)\ֺH.^* .η.r?)Qe*cı"ƶ,6{ ujGOOKam3OP2EKu DE;G/7fgi]I. u|vkt86PGSX_9sHL+ C1T.AOqڦDj,?.rkXy}gHE7!q(z16'|%Ϫ6OEV(cxXZ5quFqEh"r\ /uDŹPmNm-RCmz5&Ix"wX/U_j䋕]W?! .Uzf NI؇5 < ^lW&s40SR<\ .G'iip-a)Vf W_E =0O""iz/}&w(-i4cC|D]KOMSn63YDi{4`>a^YHq铺{ xlu<74i. Es'LEZ~r~@;0 h(~a݉cZhl׫_ ӫҖLe"aqH \ʕJ!)[ < 'bpuz3Q{5Za ߊԩmaoN?M arwF.\R>j~ sG`{$@\ .|1.e1UuN"i-L]nNCm0ԦhRr/nW4c0C_"< t [3[K}l1Su"L6m`arihw^PXcks|;F鹯b,#hq1xjWi1c66 #zNIʕ[je9?B+\YθVEԹ],(Y[*]ta0Mk`3$Nuyw p빣e3J2jORQvX[8zLҢTuWb%bNV~AmJ*m2rirȀ|6|ג",Lo˩~UUò ÊX^lCׂA|z~?4EӪ"QPx>q<T 0cS>+~bu' i /!okTw΀)˟`V)˟`VGV6G|ͯQ:".}[S.}[Uy[V6G|oOoT|!okTwΟ9[+ rtޅ)9Iq8J-f96|!okTwκBy[7ӯU XA"-8k?9s r1O#uٵ*;@Wϰ+}|ϰ+}ʣ+}_tCf_S>)S>*ٵ*;O rQͯQ:|!okTw΀)˟`V)˟`VGV6G|ͯQ:"yk9S|FPPThmKع߂o^.r(QEOU^ |ws+}_tEN\ܧN\ܪ>ٵ*;Oٵ*;@Wϰ+}|ϰ+}ʣ+}_tAf_S>)S>*@L'F6].lKĮW+}_u!b[Vo'py0Nx'N\ܧN\ܪmʎ+}_tEN\ܧN\ܪ>ٵ*;Oٵ*;@Wϰ+}|ϰ+}ʣ+}_tCf_S>)S>*ٵ*;O)S>*mʎ+}_tEN\ܧN\ܪ>ٵ*;O rQͯQ:|!okTw΀)˟`V)˟`VGV6G|ͯQ:".}[S.}[U9[V6G|oOoT|!okTwΟy[+ r> rQͯQ:|!okTw΀)˟`VeEymXN>rٵ*;VQUuZ`k^Go@]7\ʘV[ VD%¹ςo^NXN*& 4N@Mٵ*;@Wϰ+}|ϰ+}ʣ+}_tCf_S>)S>*ٵ*;Omʎ9s rG!r3:H4A#u!ͯQ:oxL@{MMZNE|ϰ+}|ϰ+}ʣ+}_tCf_S>)S>*ٵ*;Oٵ*;@Wϰ+}|ϰ+}ʣ+}_tCf_S>+/Fc x:pUM\ ^7V6G|\:SY~!5 Ԫ"d k1ZPcbG6i2bp޺QO i qOa\OF+УLS\+ØڻnfNh`zY5M傩a&8-T1mvӫ<Înt~CsYJ˝@ld[ 1khAŧd@^#%)nG ƫ,lAQR UÚ$DI+iFwթ6vO`e5v8T氨*4A-:Xw(+g8wl{\63Zg `놖Sy.þlh}ĭ`m!.9혼 gR`}H}vmBI'#,!nVM0ez̠-.Tt]½z?̺~E|yzEu u ^,m{< [TO/H8;ZU HZcSw5*۾""96q048 E9O^֧J4-4oxt-f~h9:M{BZZ"FS"w8zhkҩV? G1xL&&ZOjsy1 EǢY]QF`&m/r[c0Ž!m:̦lhp'q2y#aDž/bi < E.dHmv u܎t0*|*PQv͐"Vң Ws0O\[@eN7V6Ⰶ:F'P @\R.:pWJ_PS±hϴ[f7-N"݉8RxUI5âD'DE"km~UXR\p` sv(-D)b݁bt[UuMan$N&ȫUhXfv Aikfx(5""""".^0x?Xm6TWN9.p13"u\C1eTF*g\f@^b9.*Ov#BR{^i;! E7M54\tmUJpVQ{F LǂEH2]05Xs81-8Zbᇤ"x0y_(=' FsOCe#`Nς"?N&j=q˱ӣO\r"".ʥ:L9 _ 5iQTi4)6ѱN:;NiVYB*J"HЫ"*'6DjNE_ѿc9& YTbC v4hsYnF'69pwaπֻ,@_UDDժ"Qs؏IBz~Qe7hPn}%D$lg8⬫>:l95'nk -Ad"r,&$֧QG6&/y})K Khjhxlٱ'zX,>52C$+w"Ʊk4 e .Zboahc1ꬥU. kKiҪ^蝺@0Db/5mfRKv_fLcq RX:`v4iK,CF^Mm7HvU*{݇I@~`hmV-ڀm!l^/iҩYs(im͗m&:xq.ObqӶ Q&O:c-n[6;R*MƐX*bdyA1i!=*m鲖 N& 15k?g_ .J>j*U=}Q@E ܞ>˃ZTnӣDE7cjLk FZ74 k K\ױk^: /fu身e7 c&Ɗ%E=:9 )[X1Hk p@#څ'AQ};Mii$6sd@]W<^l4qӷ_m(+DѧD=apXt$/59[* +vXC̻yeY^ k6/.i{'"B{>058rbsia\\I6&DEHsM !̆aAԩʸZ{]PlA| .*H?L~BU$\"""" Ԏd ܻ]-ֺ) k\d :%znk1%{d$;zr:MLDE7Lx}G;h|F'# -) gsݑYxGX[_N^ӥ@&L3 g+3εm.KĆS -$Ԝ BKx7r5""""/Kcɭs)ocU=9 DEe-7*P8?r=NkKi,a`7Bҧ|LUQ³\=C0qB:4Ni, .s2/7"1|:pM^\R`c6ɒdKyOULX-j~D:jDE_'9vPg6` @ nd@^,BFbf69Ƃ"~Ei*:xWllƚ,k0p+VI|MSBE{m0.Qz<؎Mm1Myi-7pR\f)WQߑiK%O DE?qOŜa-6 @ dl쵺2ZYwa\ܵQz9wZhS-G`TPhs}%ŵLSsH A3{4 R/أ ykhsab}WG V{JqNe9?BsQe͝_6fZ;VDE[+n!` K6혈_%= 6)5i`hZ-i~d""+r"ҠZ| { !7uRNk. v4T@^X5:6C]X-G9[~ }*2׹]"$sKsi/Ш֪"憐]ޓG^?+r8Q ϯSa.L97MU õp! L{F4?wzCeFFF3P{0t 'Gњ?wzMƻj7{CZ@!jK]3A(zh54M lUcsOQ+ a[Y$6 kh5Pb`j(D~WO[OWuɢ"=o?q_]rh[OWtD~W\ .]=o?q_&\}܍n7 PKkD~WXӷ_m([OWtD~W\ .]=o?q_&D~WO[OWuɢ"=o?q_]rhGܔk159nS+D~WQ/_Eʠ.]=o?q_&D~WO[OWuɢ"=o?q_]rh[OWtD~W\ .]{ތb=~#0x\E7b@_5]_?ob~89 .]=o?q_&D~WO[OWuɢ"=o?q_]rh[OWtD~W\ .]=o?q_&ؼG GpOpgPS*RKw][C|Ezߢ`+'+u8~4@]g'+zߢ`+MY~_{B08ι%*~~y/zQz(cp=*uv[X6Dp]W.]u8~4@]g'+zߢ`+MY~8DEzߢ`+'+u8~4@]g'+,_6p8}er ?5?o"7Gێ׫_/We6Dp D~WX۩!C`\"=o?q_]rh[OWtD~W\ .]=o?q_&D~W]|G Fvc)0te9?B>8~4@]g'+zߢ`+MY~8DEzߢ`+z'+u8~4@]g'+9˹G0eUʀTk Kgv4Z٧^ʍqR.na6@_>6'4Cq51iFs*Ιf3^+ɮ08WF`Nu9Hi[&w) FDU:5"+1X6:mµJC5 ɉu Rg78@sgF뮧ic+Qcifֽ Z1xbZ0q ܠ..8CX fj9'~1F۪úqIr]k{M`p.c0@\=_Fqk"4+ f97QsEpO0E \u!Oj ._@Wap֧EG'.ԷS[m:kBsEFiUfFC k A1Wnՙ?5sk S"rF3Z2hݵI*ccZt]Za=w_rb)•VbK#`>EWjf=?QƝ0K6xѺV1iX`aip,ny Z޻W)pKs,zBõzpPiP$ e_%bipUƵ_NF\^읲FȌ4EVcSKc a  ڍo]_Ovvh *\A\kP{1Kĵ0]c"˱*r* pඑ6C[p@_4폚Oml|Pz߆PPI+8k.{C@ ^Q@b춫`8Q&'0mŤWiZf!*bSkh ni_ژ5Y@ҢL2[Ԫ0̡b)w9ҢA2 p@^fEJƝ3IQ![}JCej\1L!vd;~ͅ5󼟈Saيn6T-l:CA洹-Mxf8.LSgF *>Pp5e랓vEʃ.gʸZq85aHk 8l'u&V!>-3dC 9:9{T66 l@Ua(.ӥWc_%Z/bqT|O[e&:=zD<㫶MWI7u<6ի>͸"g9@^ ql2Q%63'^/FZ,eF}:--'{.`dn%mqjVۮYk..%hВC1_n RR\C"OaU6h}J$Kvs[Ѭ-q@yEԧ Fp7-_)`jXo5R XbL ^=Jul .(PmBk˘UyOp151j i~!Ԟ!0fG־l3lc).6DгgI^yG j~HهÌ5vd Eܞ1zX{vDLA"9#=oBUzCnH-~¹TDDDE¿]rRz>JIk7BUkK  #b1U;4s\%zؿPz8#eFRƻfG6cR~569u*2f#G]J5,B6> 4uh/+=<5L5vVsF\u@eWp̻BrW^'a2btbJ"GU8]VTqN[U)鴰RZHi9/d$uB1.ǼTA#>Q e:UjΣP0t;8B"Znc4۩ьO6Q[ۉ\B"/l >|osbld˳5.J-zEOSn\m1|< S=w84^L6-8Ѭ\Ǿ b1_EHy8M,@L2H="'( _K9>kVMF:7I@WWQvR-.5v #󾵰6'gm xw`10Nj3-i kz6|E& 6\>إI;BF=P XSgƃP]MÞ{DӠj:}jEGa6Nإ1bc;mcc yktn@̸k-P:ժLN&0;k\=uÿ0uzqnWwFˠ"" "" "%>o BlDfEjPYo9S?1k.6EO$`I?=wL6*+aVͧAI+)''5\U~ȧEm59YzUy_qVh֥U7iap2H3̔EG5f~Y\TIpsYSchWF6'd q}%,VkFH;-P]b0qvV@ LY۳bz=V=1,\!mZnHyW*7]vl`[g-tů=7gu^~I`QFYEiC$ J"nr۩!C`\"y+רּn\ևwm^Ac +cja*Q6Zf=s߅~!bC*T@7v>4bE*x3i-D4z=V(F^ǰ=i!hU-W Ċ~ɦ 7Z|GX>G\+N,5o #iiWsM&ˈ'0kz?P=e2XfjdIc$ȘZ5haWkOm^^SO4U;Z괚kYiEPTf(b6A[͖j"}qZR=e۝m23znrV6Q_yBjx5*mm6Z H.l o*:@nJŀ܆Eâ"""""/n!8N{i56m'dPxu^00vD=֍/&>G SYk\aK$-9Ee\?IJfsv:fɞn F#M-60 rڍZwqtƾJ?QCtG#ahѫc\爦di?_Ef,Эe:NcJ6m=vcLRY1ʕ^, psNM~#ְF0wADC` x'*>6Oj^ H!|׭|b8Xk2SC%SyQkӆl`]%bu11 5qg K!u7A}uЪ"Q]79*Q]79*UNM\n\-`97pLkia.f7l2zm֨i:_9[NZT]Wߴr[NZT]Wߴr[NZT]Wߴr[NZUk?g_*V0?ӖG*rw(xZ᪷f`t 7/Eu6$e?+~P*[NZ+~P*[NZk~P*[NZk~P*[NZk~Py#aDž/wuh/)/]! 66!ri 6!ri 2!ri 2!ri 6!= 1 mWr\O'rM0is놵B~0Ӗ.UU6!>V0?Ӗ.UU6!>0?Ӗ.UU6!>0Ӗ.UU6!>0Ӗ.Uu~n#ߴr1L#U0U]"@E"au_k~SmoC9j"Qu_k~SeoC9j"Qu_k~SmoC9j"Qu_k~SmoC9j"Qu_+~SmoC9j"Qu_+~SmoC9j"?N&j=q鸿GjTw+]KQƩ"՚쉾K[NZT]Wߴr[NZT]Wߴr[NZT]Wߴr[NZU*~~ymoC9j} lGZwF.OUq9-٫\10t1e| H`?-@\.moC9j| H`?-@\.moC9j| H`?-@\.eoC9j| H`?-@\.eoC9j| H`?-@\.moC9j| H`-@\MO_i tڌwL9%EOM?/YNQGn/ DTj | H`?-@\.eoC9j| H`?-@\.moC9j| H`?-@\.moC9j| H`?-@\_7HTr[NZJXlaC{XsDdOE]Wߴr[NZT]Wߴr[NZT]Wߴr[NZT]Wߴr[NZT]Wߴr[NZU7l`?4ק6!z<\/(+n v;e@jPQѪ"Qx|Q~Nh bV'zBB9Z^.3-h!t|Xg`^!y=hh%׈ V`' /mjL5/ȶ .=,ݢ^تD4vD:R6_R*3e6.@^/79b&RWǎygh8\;֣=(9^mQkI%Q%{zS@6R0 ,\;6G~;@^/*ME):U5fq߭TK9{ЧKf$lQ^ )涣sI05*d$;1LMm'is\jeƨEVbM@uF4-x+ʞ~$jSЦL $ot)SW1VCyDpx U/&v9"ernR A|}_ k?g_ .I۾TEu|vkWo <.Qu^~6HUzAcگ"Pu~n#WOoF?ؠ.T氲sX@DD@DD@DD@DD@DD@](~MzcC|DDDDDDDDDDR퇚?ml<M]Gÿ0tDDDDDDDDDDDDDDDDVI|J?5?o"=6P# ]_O vXӛ$*y9q~!SDDDDDDDDDDDDDDD^sOy oi/ШҪ"1<.(ROf mIu&Rb9ʡ-6H]pJ!i- 33p_\- iU(Tc0*l4aHШLlB"(rhTu;- ^auCFX\٘/Ot0xgզ b&{OIpnW0b P>o *TK:M\|1Uf&aկ7hH6ӨʌAoAĴ1 ayܓ᫅{;鶋opdtz:N7⋩{ ,kA.X=&yq GN⵹{1 n&i|}Oȯ -M·Etd 1l1JG}7R/5.Ϯ1yx,Qb)W ;'"5zYkh7cjeO. @Sc990gaș l5unK>+R:٪dKl q>ab0t*Я@L>jhp}joA'֦?h5;SB"jܩZ`)U,zEvX <0l|62ù׻ S[{뺡1Ηnya:jJYI 3bhȘ7kQomm 6^"`(`fAWTbɅs iS=K 9Mg`G6ٙTm,='ҥK wJ˪A7pEڞ۾TEZ}caK Kl,$B/!z\ ̭LաYQvã0Z0GR"R4+ omt?6+r'3eZpͬ9cL^~#0xSvCR,1rsR:6'2 [R9P˶YzNF=LS]vc4ڡUɔb\4D WӠugT9GeEb=J86i;>!aE=wha9%#ALDeD$I,!mZAuBCl@gUz9qxԍ9/׿m-.%$ENkHqvԮ-hyfo2D/{<ʸ|%P5*6_EFﱖB"QyF]e:ki^Dؽz|*=xF3j\*(݋[ ˸:U"ήګJölK>+s]Үi36Ek=i ;xpW>S->y`!V2@&ˌ@E?0Lz[8Q{Dju^;AÓWo&@W/#ӯv&]RJ &F;h UؒiW{)a~sl:hrS%vl8!:C]}0bW+47hRc\3̞wl]fQqO:ݢ]Z5Z0.L=cG]O+5%T})u?WI]F[{n t Z `a uMˉt$Ew$0UU: E&01rԅ9'9,Wݴ1{R MkZn z֬k {@-t rDw CfǛj5~aQŹ]l?W.ɘ&a]L Gm3sOc #Y\]]Ꮼ }Iؐ-29'pհRžJdG`Hqxŕyy<0ھvIq <'/QvZF7LWD leޑ)͆L-X/',8r(ӫ֯JjsaɄ%eԹ[AkS *U!t@5#8$?kYC haVSoiD4@59Oǿ{NP-ZdYmX\*6 +sR6v,vKc"w*kaZf2sjTlA3:TY6nlTe69㤥O,F6aJ[ SըCDId(rWqVIS 8)ɜ3VeZtPsy;L:76yjL kzA\-qfRڪڔ[2f8Ic]v&.!m02= /\r7'իZ0 )8wvk\slC^seTl;1i4jxJaT59 2/FTWzU2dEâ""""".ɘ*XwMGƾ!Q, CSU N*9΋05b (E8VJOSFja0]WsKvkׇ 7{TҦ(mAN9ZykiST&χ֖85D1fOZ"92,&0PF]$[ULR·6Uc6O c|dyVTq,sjnrc@`jaO:Ӫh/<` /tr$mJphS1smW&8qL^ H~@ݜ t*aLFШ o8/3z܍t8#y1UPeZ<8l,In҈Ӫ"Q[ToNb|B"O'1S!sX≮U04̀/yX>R Vp]'1S!9n"^ZkdD!s6m<5/Mvԉ6:.ØO /!z>%hiI ِOLI6mI3suO*~7 .VXz5Uj5"o֋I%zLV<! *~79.M,u/Yu*)"zѼ.q6S C@30b|JVaPNzfr y[ToNb|H*~7'1S!r~?̺~E|y}Jr$9W흦$oݧr"tO'n_vE?i\O .aOݧr|?i\k?g_-ܿ'?˗E臢|ج?7L᪴; @%|⧶>j+w\HO%?˖>r؟۴.@\.7/O bnsܿ'?˓7/OE"r؟۴.Oܿ'?ː0 bn>r؟۴.@VrG寶 _GEZ"r+b@n <^`@޹ܿ'?ː0 bn>r؟۴.@\.7/O bnsܿ'?˓7/OE"r؟۴.Oܿ'?ː 1 mWrܱ+7hRTPڃm |$ۗݧr"tO'n_vE?i\O .aOݧr|?i\]?n_vܧr"WOoF?تr؟۴.]r'b1OaSZN X@_99. bn>r؟۴.@\.7/O bnsܿ'?˓7/OE"r؟۴.Oܿ'?ː0 bn>r؟۔.@\.7/O bnmr_'9}/*sm QT{ٶ4Awo7/OE"r؟۴.Oܿ'?ː0 bnS>r؟۴.@\.7/O bnSs T]/n_v-Ldr"zql;o# _E^W.R5}f 7/OE"r؟۴.Oܿ'?ː0 bn>r؟۴.@\.7/O bnsܿ'?˓7/OE"r؟۴.Oܿ'?ː0Sv7/O:>r*1 `}=6P(wܭ|FR4 k bnsܿ'?˓7/OE"r؟۴.Oܿ'?ː0 bn>r؟۴.@\_7HTr bntW36i3ma3@_3E?)\O .aOܧr|?i\]?n_vݧr"tO'n_vE?i\O .az?5|?i\E;W Nv9ǜa  /"Ԫ"ޛGy^o-c헵6+# OuJpmKC-ob"vޛGy\ymAͰ;fIk!w0ސRR-^C|Pw;z7ӤlQM@)hsb]2@Z:~~l٘e1M{ׄ}(tE:tK@3Y} 'L3QϣY Ѵƿ'1ͣ{׃K| zRh_K &QԨhh%`"6ޛGy^^hc5Z~ɱ1 *q^᰸U}:la{Z Em6޼8Yݶ"vac>Y)R v3$pE6޼>ѭhuFCOHt[VO}E {kvH}{QK"ޛGy^(nZms)S$eZ/׆b6y5Q=osT\A:oo5*_Ve+oMoʮMoʮ֢ -o5*Oo5*Z qd? qdj""1[u WjoV0縉{ĮY:As`sewαc&W|Z>j(oMoʮMoʮ֢ -o5*Oo5*Z qd? qdj""1[t1[uf%ޏrZ{]q{.cMoʮAo <.Qm~ɭU:~~ɭU:DEc&W|c&W|Q7ߕ]7ߕ]D@[8߲k~UwΟ8߲k~Uwεv<ijyͭQ~ ;z1[uAcگ"P7ߕ]7ߕ]D@[8߲k~UwΟ8߲k~Uwεm~ɭU:~~ɭU:DEc&W|c&W|Q7ߕ]f&/*V9;@s`95u~n#"(>ɭU:~~ɭU:9 -o5*Oo5*Z qd? qdj""1[t1[uoMoʮMoʮ֢ -o5*Oo5*Z|~/D:P=ڠ=DCL qdtܡt97{W@[8߲k~UwΟ8߲k~Uwεm~ɭU:~~ɭU:DEc&W|c&W|Q7ߕ]󬳔1[1iSuޚc14yYͧ^{6Lh qd{~7ߕ]7ߕ]D@[8߲k~UwΟ8߲k~Uwεm~ɭU:~~ɭU:DEc&W|c&W|Q7ߕ]7ߕ]D@[8߲k~UwάV8ւMONqF<5ڦdl@\k}ԟS6SCƢNqވa{XMq@8tȀOL]?"<˧Wǐ&[ҢC^g 0OVuJnݙ8/3v N@q9V60څ}R]T h![((b*a˪7ds85S{ib]Ϫj9p̞G8jTu#VJ̫X<L  ;_#f-5z$ E3h-GQ}u\PcƿyNHû V.0ǜ0'`熊cj y  %LT[f4j omJNcG5LlfHJ" k]JZ~ryl9 `F4pJs\c]JL uȷ0t0UJnXn`S!6䛂Fy]ܩ h98,F?PըKK@ySw5*۾"# B4ԧ͇l` pK`VUjSبֻe3-$a@[u? ex\H 4?6]n'`7@; Snp8CT;Pm=!x W+ 鹂/'f[FDzۣ m6jLk]9,ldE*|w)Vk˛-:Ȥ \Ɇ2$>ȪƇ@"\FZT7ꭨ^)Wm*pyɕVpV֬{MR)r)z9']Mu'a+eZ!@y=LUTHPĺ*H˘j=]8v%§NGFs~t= Om=\'A~ y~ c&KIp%9kL ;be7q>LJ8oYcuWkycߢO B*5jaa;b DɼD_g52ZNӶK wkYơm*Uk.CE9/ l5v9 d=1}B.qc=&mJjegUd5v@Qw'˶ݵB~L[hv繭ĊAC:7&N.yEX5jm08'y*8[ uqZSn\4e{_ti*FYѷXٷ[=*mGmU)ſ]$br'VŜUR-c料l8#L?Il15iTsu6$@k:"09#zrn9clP "" -J7Ise w08WR4)^9q~˚$8y cW ٙi"qN&d$;[@^L304UQ3u7}Ub# [SӆH9uFT.va؜]7ViMc^YW. 1ߐ3PL\S8&#Q*3)$DvU֡My孨ױeѥ8'l=-LNcRNyxnIxw5響mgSZNC#1uI*Vls|FdpOR7FS8FW=$"#_KB7^~Ш_g -ta>R슕?Z&Ҵõpe`V#1S2,MT4O!e'EAP}G=Zߑv;TPpa0 *)rfszGJsUSReޟd/Ck?UǭEq(rV vG ƶܵ^K2bT5)KN*L95 (gb9?֋^W=龿2z6w֥ZϦ36PWҧ۔r Шaac';@( c9Smghs6&\x+ఘ>Pœ=|KA\,k)uSf.Vi{O4yJkaChGemQE͗=']e03E!; ,px;7:bg47!-3]Ș\ت *Qc^DX*8)9=.{6z&'5z9lSnzB"" ֪"Q]79*Q]79*Q]79*W%[M*T 0Sl :+ޜs{9aBy0t-Chkny؎xi90E7B*Tug8@hw0ހEw0ހEw0ހEw0ހ/OL]?"<_%?+՛Z# vWw|H`+E"0_|H`+E"0_|H`+E"0_|H`+E.Y:A>0_=b&r;viUwH "Oml|W`B++>0_"u/>0_"u~/>0_"u/>0_"u/>0_"?N-}x\o'/V#r8Q,nÁ'EH`+E"0_|H`+E"0_|H`+E"0_|H`+E"0_|H`+EW?! .U}3J1xV5.}P̰! _~W ! [~W ! [~W ! _~W ! BKx7Y!עy:&j*T8w(8DAbB/_/>0_q HE"0_|H`+&  EH`+[~W L$& ! _~W !#H$L$B.A_!=C\.G0HH$\.=C\'z \)r_'9}CJޏ#{CT fCjni p]z Oi p]zߴ Oi p]z Oi p*~~y=oC\)7Њ ~E.]}/E(aiFvj wELn:/=oC\ .A_!=C\ .A_!=C\ .A_!=oC\ .A_!=C\ .A_!=C\ .A[&]Wz SMvca4(OM?/U^S7!Vk-c_~WEH`+_~WEH`+_~WEH`+_~W]+ NP_~W W9:-MQ͐v /"0_|H`+E"0_|H`+E"0_|H`+E"0_|H`+E"0_|H`+E/_ѿc9潏i pG>07N 먈ת"L ױ˃>KxΠ o0u)(cjS(r{@@ETW*bjͱZ%[d8n%קRi%lE(ƻA9+5sKLcL];~l؝; .SҼ]>vpᅴh;um'(2>ixik&ݽuO8e6RTvF v@r&zQu:[U*=XvHEMNg7-qdcTc{:!Lf"'KIq/`@]R.O ܧpf}3` 3]B66Zg)Qa l3vhI^6}^k1Z,W9Fe&"$1tԠ.=&bJ[Ji\$E:úmJo}&է͑bs@[>?̺~E|y}Oȯ "" "" "" "53 @?Mg E?w*۾"" "" "" "" .?N-}x\#aDž "" "" "" "" .*H?L~BU$\""""""""""""".П7\ -G\ad氀hNB;::rټaAVs+ӡɿھO\ryCro$TQR퇚"867rwF.?5?o[&@]7O ar۩!C`\"""""""""".spąO'.5vXӛ$*y9qsi!z?4EЪ"(bK jmiiB` uG4jTfZ%x-@^{yne@6bŐr/&fs-̌bhO M܃[8_W^eG5%Tv sAm4 ?'S m X^/,CV"&0p$E-zޔbhKaB}]Hy+'LbŽOթ FȱߪjzUSEe>hKj6zKK+ N4Diةt^L`_Ns`6 nY- Sgk^07QZSH82"O\Yl%bX;M{GUU#xm)PܝE$7GgުRʘNz*6,%&/ @ZQ/q[8pMܛp['z;51UNEe"ggU睆jH;Eeže+ h9=0t"9UϭCsA~`6 Xbt0X&4WUah2- u.}ސrAz\dĺ4Pz~sPNFHkSʵps 9湿Ҵ$::{F{]E(c5"R]:m/s@lظq\! TiH; mGGA~!Z5m=,d8JάA:֭L9AٵPNS QEq.o:+4pŠ3>QZaQ}X5`"F6(v'O CTĵS i^XmEx5yk6X &?Ms0d[d6%v^r'dv0UCZa0"j{nc梥Sw5Ez?F~RʃiLh$xO(apjQMsԪR^ ѭQKd1kv LK֧ևzZ &-y>TR2sF%št̆ΏHyD G @/JHq6a{v`Exң_KVb Cj{DM$ Z،>԰jP^zM4g@#KMg5/eƹ\Db-cia_mOOh.ـpEc1Nw'U`E̩P2l W^.0m uM5ϲ@.qKHPk^ p.4 dwb&{Z֚LFF"hC@FȁWpo$ `=7HH+w<`pa 1 jTG/cgݰ tEⱘrfG1(W u"!n:Schaz-̼mńWxkiI鵀d\ <~,IuF5N8 "k_Qƣ1upcdds?6rtpDqawug? 7M^KPs@]5  0Ӗ@B0[źj HgcQ (,+61FaFHFtbpXd&  +Œ6a!5!at6c,,cXHl$6- '3HVeƜQHXHlZEa)Ł:9ѫpáa!t,:sM{@ $3+Fey|,:݄Hp&a0м+DF$nã$6 ᑆ BN"aaؙ͂4cV2c4,2vBBDSa!d,,%2XXd,6qbc$s8!Y/qM,II0Ƥk8"5aaa!1âa)I:" #i(HHH!"X#BB¼wH BBN!!GPUYvt97{W](~Mzuap!H똷Ӭ C`q<^aM{AfFcR<+RTMݧS˘;9'ik\݂f @]Ju9>ό~${As9Euz.cѩR&h|f:[Wir r*q-,'1khpsF;#ofggn6xJ"856rwF.J. -c15YXm3Ur<. U(@lk6Lڰ1i+3F5!'0 i" a7i#PCqw{j\ֹ ZDEb93}j" qYaw^)4߂kG7X7dYL/ =<&T;ÔaP[ƿ 04Z6CKKA$Er5aG B:‘mf4N";VsXbUS D7$ $mHr="}0 `$A.`OXX%؝9M= #dF@]=Z+;! ڃ$Ș ơQy:PUunɠP DZx\O"ѬI.sZ4-F2:XG9{$ksv/Snhz=ЩZZbaC[u?( +`+6lo`b8E\S JzOKz.v 8>B5j9RmRLpm%rXbaRX^ KTҭ-{g8ƽH P_; tt>mezF"wPVk(5uuPV^>-vcHPxt*aYeR@/{Pq:"hrUSL)7gm0IsZ|Kqo[Te,cjWP5\I'%VejTh2ZΓrs@7k TC:HkM&_3'S_*B 1Su(,qkd]5VĻ ί)w~՗$Sžj4t:K9?B~NLOKA@ zج/(8zI%6I:0E:ea`0( 3H]YM89õkW`1J.R,Y]71&dU¸\Z[W[ !s[Ef1.8.^؇R G8`kiP3]UKf;M1鲐m@ݞzh\MUЩB*C-e$ZFΫTb ĽTdl45evfaJ|F$;>CFt6NSصyV|[SC@cZ9_<3CvUc*Ȯs\ - ^]b 5^m荮i5:qѪ"Q[Oo6*[Oo6*[Oo6/38 kFWm8I NMcMZA 6%OR?ٿE"S; V [446ع]~)Ooyy7XԠKs AF$kszn-.Z w/Knߊm@Zl- 9IND 9rnߊm@U"nߊm@U"nߊm@\.__rW;zX`zDt_=>w?.=a} -OGhOj"vގП>w?.=a} -OGhOj"_ } -]{U0IΗ@؁"Oml|Wb^t"M9c|Z]'??E~z;BoS|Z]'??E~z;BoS|Zӷ_m(9Sn7Q(ˡA?E~z;BoS|Z]'??E~z;BoS|Z]'??H?L~BU$\g+r#RK[Uh4sm&/&>w?.=a} -OGhOj"vގП>w?.=a} -OGhOj"vގП>w?.=u~n#|ZF[8Kpܗn ti%kg4RC`5}]ž_39.|ZގП) E!WvAqGhOj~z;BoWw?'x#ƊC`Hlݼ&\z.|ZގП) E!WvAqGhOj~z;BoR1Ӑ!!!!'[- (~Mz1\ &៊OAv^`ۊ?(]'??E~z;BoS|Z]'??R퇚?-GIr&Z867˯O܍O^WyxX /|Z]'??E~z;BoS|Z]'??E~z;BoS|Z]'??VI|W} -S˾:H%>sESBEJ[xK"j  ,/GhOj"vގП>w?.=a} -OGhOj"vގП>w?.=vXӛ$*y9G|Z sw&ma]{[OEeQE]'??E~z;BoS|Z]'??E~z;BoS|Z]'??^sO{?ގПտUC N#U]Y9v\ME}uҪ"Q8M<תHLKc\_crf%i{3 hz@UR {5q&)\ֺbWr+) S9^W'bqOzXUk%ن/Aܐw/xHWҦƶEW䁜-5qT(bZi1"Ze!nrB?:0T,v r-2~ ~EAH;S龰6?l45odz{jz5n֍rȨJv . Aܾ{w+z}|V9꿤[ds"uݢ&T*o3VYXcv6lA f-j2mMnrFue+>?̺~E|yN7{i=fI-P_&9İ4KK\׃ H@Z(JiҨ0hoI덡2Ir1۪Q#3#@^J/ZVZ 9>KdU7?ap%-H&8E.Y:AxuyE^cM ]v C\&)~ `nE@\-Oml|T{nc梀kE;v܆d:"ES4q^l $DSaOxfQNR6v\ׇNPz"E9+qg)X4H&NY->"Ms\ ̖m[x 2C@28Y[4TWsZ͜;5L]E"0On`ڂuYw"VPsjc7.E"(/4UVi-l¡GCesZeHh$7J" 1 mWr/_Eʠ"" "+(ѩT\fI[8LruV015 i#i"z1t*sM{\su;OC\M59i[ M -x-vH@^R/K Ș_<( 4\Mmȸa0R<>vbvgj'XE.П7^EnB6. QCL _o(cibC 1neENk?q"IsX$qNtEgNZHh#>廅 ~1)c6?a}jl;[s /%N3kNNMbh3b!T:خZk/Ah$@@^b/R E<3E%k>$MR(VV:m{U[' "Cro.Rio< uPA6'_?ݨډ!y跰\uB\9hL69O]4 ~;i3B"n7qoFi8d}s` s cCfևq/"ԩmar=0$2|kpƚ_6Ki;Q: /Wӏa|?\=867ˠ"" "" ""]4`vbvB"zAr>s9D-fn)̭Qe=` ؀z}/R 3b @텑(IMCViie&xE+pݾkz98j6V71EPc1U)E&h'iN3"bSBE{m0.Qo%bPa_!. If+*N}m9t/OxUj)@Þրrq*% el:b/@Z(܍}")U!.{2dN.w rjҠivIk9HItc]@^R_7HTrY\EL0) ~r%]5V:%T2$mj,D@DD@DET|m,#q-y^1imR2v2vA q+/ls0ŚGyiwH%А^OGJZ4G^v!p{DB='G8ƇȌ vD<:A@^B60Ú~jXoFK MikSk幍8\T!qA$O興Ӫ"Q*ikI0 6"0A+_[BpH2d7\]|̭O+<5qh?``cEM&cRىvsUZv=9GJ"akb'ca@I53`F& icaKÔAēI@_EkŷK]=e (iy}jR#ZaIߋf<֗Bt@_E]qf77'Im&ZXFb,CyGM6s*6>]3s.GJ* V$V^p9^K9Iвlɍ$_$Eqf hF]=) SJ,.֐ݐoD奥p<䝣'3&V$@94ELLg7'Rj$H?L~BU$\""""g(R m`m96ez؆(aFUc%ɰ3)8$u%uZzT?"Tc΂ֶrio'tJoT=츴dH37\II;@] Nŵ9JZh _<-ijTD4}7i\σ& F̘6@]L.+xVČSJ*$e]{8 <:ѧTQQh;M; $gu2%W6]WN.cI$ECaQȘz3V6W`{fbr!Ź'qEbԧLӨ9N%cb^0?3 $\ 4ۮbOrI@]'V? n06Jki ߨ}mӦ=LF!J2ժH!Ŧl'L/J8 02>/p5_ goj~q7PUga6ЩFs{U~6ln_[܀$VNx5Z< ;~{;ϟƷ9 *nqNYΐhWƷ9 *$VN|5Ew>[܀Ew>[܀/OL]?"dEʢdcSM*cSMO;7@\53_ j~.pxJ14v&TEgnc栺zaQvolT]Wvol j~"Qu_ j~|1G`?E|1G`?Ƨ .UUƧ'volo <.Q}'#}nEdEʮП7XcSM헿迤bq,8,%oYJ;1&ODk cP~|1G`?E|1G`?Ƨ .UUƧ'volT]Wvol j~"Qu_ j~|1G`?E|1G`?Ƨ +Croc=OSQѣ4Wkfy\volT]Wvol j~"Qu_ j~|1G`?E|1G`?Ƨ .UN߶kcSM[B? #~)RuVD֣a6^volT]Wvol j~"Qu_ j~|1G`?E|1G`?Ƨ .UUƧ'volT]Wvol j~"Ujn51G`?t/ovK$a"O },ʕ(RvQI2,4^volT]Wvol j~"Qu_ j~|1G`?E|1G`?Ƨ .UvXӛ$*y9k1G`?ˣ xB_{yGl|UƧ'volT]Wvol j~"Qu_ j~|1G`?E|1G`?Ƨ .UUƧ'volU9l`?4קƧ/C}*%S+l'6@_bDDժ"QXtj=X:VV}9=by_|yĴ؆X]9s˞)g`T9*'5S+r.#[+T4piE?pt^r:Lks-ޣ.mUm>sg LKFo.MG⃎V^4YJT"- |;.9h?x 5͞wl1mayS S.1 ¥葦ӈhk2:["du`9`px(^+8H$iAy*I" TY{:6)&4ɍBzBi=JO,痙'xW7@%ŴnPJiHڻ">rl8pְpKvFw)|!MsSp޼>m|> ӫM,qno௥詡v6'gvGe b|PKq>) ڌ,OcY~$Us9ݷfHOL]?"<˧Wǐ'F7J0׺g.c/Cp86PsR鹕\jAE3x8W2|3 &Fl""8?.RJUn*-!Ȳ"t/9HlE7UsE6ZpmS LcʕhkX`8ӂE.Y:Ak#0t0JV겳 pƶZfJa|a(\wTa@ny /EJ>j(^HP;FۛLĘEL}:c5|hRpivn2 k / GJ(եW42{" ^?&aV}cU!ih{'lA٘14]A8AÇs g@ nhp܎j'ىP4nIbkզm:uIѲIt8!a_ͪW{bG2^_Nֹ .YY|C݇c׽XKK 3ԵL},CV# YbP6Oo5aT ]'wP pSgh2b$}rۀ~QوcjL NYozql;o# ]Gÿ0tDDDDDDDD]-^H3 sSYmrsfH0sE"y&b!bWs{VVcDia>+{,7'HUuYNfr,_JXN9άڬl6KX:$2FdzE}UnsuF6ɨc"Ujn5R &iק^\Uj9S,Z6uss4T ؘ9+==6P(OM?8,J/cEGSYIӴIhr5Q\8&==n@ gsEņskѧQ.k]I5 i ?#`s;mgQL s$A .]U[G )1&u~y`siѴT9OcC BFZF=ct0t \I]+ NZ+QQMs;Cqor?D7;@\J" "" ""q<}&Ky !ٴ6$.iKɼPsE'S 1A&xD].NFo;J6 'dؑE"1`YU+ҦUU۩NT@L 0aq8-)׊&Smgdp D]qoiG׭q4Gs+2#b!ߣNOZ"k2@p,~ۣd4AED@֪"Qk14]^!MEu.t9ja )`-Hؤڭ{۳%@K5y:ya \Ú">rpm7 m2\ =F/B$A"&:GE}v'v9-`)aQASqe NH`Q<\mC4qvPt*#>O,{2|>\ciCTGYVwԪK+@#g맱y\5`}_XK (e:e"L@^]WRlk9;'5_L62Jv)4-z5_HVٮ4Z6X\͙33 ?8z˜ekv@j"Iy4=)V?OڏuBҦǺZGFܼ1uvcBg`k~rϢTV5jVmaoD9n^Of ':)'[SNڏu^&10bγqg+a)z*nEf+X%)z?y>y6( ZGAFYSE;Lgo.Kw4Z#(;%6D{AcOiÚL .1˧WǗ}=0t"bKJml:KrlGr1\ɕ5:5cj?S"vm˝DES&aEzc KCCAn2yoZTzSsE}%цzY^9oxQhTQNe!I`ԫU+Ԧh1.">z#Ewv!-ljQltʴRLAËmEk?g_ .J>j*U=}Q@ErF>թbZa4*q-OZtN=*Ej%jC)5=&M=&b09µ]3L8ɢ"|PWmF⨗VibuןNUj݌{^햊A;%xzIC UR>-uc\5X")9ɺ_Kie<.*A8mm@8.]xyAm6v. u|vkt\>qG}6 7Ϣ"sFW+0hsq2ɦn8i: iR\ݝ;Ru\ . \ÿaĀ;-)m8S` Gb(kcLlmBӊu.~Mc[)PӫMO:MHuj;ZZ5Sd r*MrH_<㛨V'%rk/_Eʠ"" -Mz&rݦC1-pW_<QFaP5KvvFP@^?r BjnNY65SwnewԥEV=ڒ)p@]\"JԣW0,1V)lU#Oe؊6,ֆo""+zTS>r.v422fVo*bQ4y#Ͱ4-:h|BKx7r5""""/syKBTsUiD7]X{v#ע3ӌd; <ĺW?[=WTj8N˽:EyV^1b]i)sNlҬ:‹= ¸EJ.\(՟hgћBtnYr^7ʯYX- ٘fNe]WZ8:F'R&W9}mK[qT@]c/q4.PcEE39Rz)Bh`u]Nш\:_7HTr"QKWuisS֪SF72$]\ .˸^Les8= 8DD 5[;7*]8Sw>ett;,wXo+ԥX4h3Μio?,;Rﭹ7ݢ{Y6[g*LӼ/k_ɔM:ъG6m8H%z?4Eת"h8&J +h8&J +h8&J]CV8o4-犝-Cc@]f٥ܴs s\>wom{chsH5#0 i~8&P{q4KYNX@͔ۊü07 io~EGǹ6h8-?[Æ:=Oa4&`\s\?ONqv)~<&qFN"L v 0cQps\$9G4{fr4{frUN{7ip`D/z!Ib?(Wa˧Wǐc]%-ODi,Gjxgc+ӠN@j{^LKkШ3ipm/kKDZވ~X'~XTv25$'+C)Pv uVӪڌ s 2?Ey?V5b[8=mw'z#&yK2g cKDZ ۾.KDZވX'/G=uj6꽭pn]I@]w?#? O嫞 "4ls8SS X3`eZlpd@uH.C~Q?w#y>Cv/+a9PsêZ [y9xLFوwPkfRins@^w?#? OrVF+ ug2UxWuq8<=\S)M08C\Ll>~Re,ugac+cPso0!sy"Ѻ5ХĹ[M8, ".G~Q?w#yǓ926|U06C'  .Of5Hs];nTE%:(AAI{v\6mxވ~X'G"9#=oBTEz#Ib?(SKDZ@]w#? O嫘a2Nѻ'-T8Fѭkak݇4ÃtE~z!Ib?(SKDZ<6"ꍩPOcd8@otդ5jpocj $ E6̙oKDZވ~X'գKps(M*-:LTlGz j15^M1Nh.C~Q?wѬ֬L)p苍˓r Zs w Fq؃kF!s۰莓dE]%-ODi,Gjk.G~Q?w#qȀDi,Gj~z#Ib?(WJnhR5M&"5(.G~Q?w#x>E̗scK3h'@)r.Pf!ԛE9@6/z_ވX'.G~Q?qXMvKA{:kr•<3ҢT94oz!Ib?(SKDZɸW}L]_UDs3Fpe_S :EŌc!T Ԡ.}ޏn QL)l型.G~Q?9^i?ڧzc]%-ODi,Gj㗼C&Ѭ}s4OB" O]%-^'rc1q5 vu Nx9l;GۊꢭP 6Kdu,;/WKDZވX'ե)b+٨W 6[4׬שLYahv$Egw#e茈,Da?  a|LPk\<: 3Ob0Ŧ2ȦvEs؀I~Un:Ed0l9~z!Ib?(Vÿ0tEz#Ib?(SKDZ@]w#? O嫎DEz#Ib?(SKDZ￐3_ϟ\mX-sD@^w?#? Orc1|Mck^(/plVVy9Ϊ*k( & N(.G~Q?w#yqZ4L䌂~MV9pP{(=vHsKAPw?#N'$*0B2sZu=MؗժPKXXr'j 5"ehS3 GCj8XIfh@]8?Grݎ֣_,e26L O媟OM? .KDZވ~X'W&PűqUB{if5"ER04pᱵM&RqkM1ȶh.C~Q?w?#i39ak⪂GK^$mD(`* ]:8mS,fdl{w#? O*8NyLR5kk n˾vRgv>VZJq !dE]%-] |' Gpݍ0C™5 H=!~" b@$aNle^9oVU@$AР(~z!Ib?(SKDZ@]w?#? O嫎DEz!Ib?(SKDZW:tp±8tUKajF]%-ODi,Gj7p5qf(5e='inGrnؚ>vޙ;G{?ވX'.G~Q?: }Xv3lis։RF9ᨖ7j ƣ6̠-Di,Gj| +^aY 4`NK73KsBZ'i~H8>^'̑Gd.rshЪ"Q[Nn"?x *5\(U@.9?EaN"}Pꌬ@kNftPoGܝmjYZ^͇nw\?x .8j>4 n*,>QV$Q#RÊ p'fNfuNn"Jb)W ehcSCR5!z߄NaOZͪz"\aOs9gm9/m*˨Ҭn٨C亮J7e4IUtg<9Eo7Os9Vtg<9?OL]?"dEf .O^ka9u1o 3-hNJ<1up&ݰd$mz2"NSn-mrKln&/W؜0u`c1xQQюh1Vr6O? 9oާ̀ZOZ˅r<|W)yPRNAN2&^' ~m($mz2~r6Oxf NIMqhZH%zxSOCOʏmQL>ɸj? 9oާ̟MoS@WXaĜkE'1Ԩhڍ)C)on7ccفSI>d$mz2"&LU7Qc][ef=5U]s5M8שE; @3rUMoSON@7 +|P8s+2L],;`puN7zFrF$U|lKL J 9oާ̽F9/0Kܨ1v \Ea|r"auMoSON@7 .QWI>d$mz2"8œ>.Y /oG"bn~r6O? 9oާ̀L 1 (N*84ki"*ʸFj JDq;տMoSON@7 , ` ;׊q-'U^ԩZY46aBcGj$mz2~r6OK|ŚU\꘎hs-`iaQ<&*JxΤF3 6Vr6O? 9oާ̀yrz3*rgq|NwAf*f#yqږ#z 9oާ̀E?AF k~QfI>d$mz2"0Sѩ{)\/O +^FTœ>QP$mz2~r6Ok18*x:81v,;ڏymS8lw)T[[l2Z2[MoSON@7 -~r{֫;V&>h)HȞ1&`*5TBšN ٩~r6Oe9m#>dE_ÿ0uJ9/1yPas4G6h  9oާ̀D]_' ~m?iM|Er6O? 9oާ̀ET.OG5]7hl~D@g?iM|I>dEa,L{)sUýZA$#ESNWمeppvH 9oާ̟MoS@[}"b}]ia]{ꘆA\;(T9o_xKpcKKihڅN@7'' ~my+MJ/שWa.vR,t^{1jaDtjTDzlX6N@7)NAG-4z==6P(g%F'Sʃ TҤ #E 2-qu~r6OhN'pbWeV0n EyF5>Gi@g$_I>d$mz2")[Tvaim2rjllܬr^? Vn#Ί|Ij5qVr6O? 9oާ̀l nN}u]SpƙhGlf+p1' XV1vaەI>d$mz2"eJ>;p=s/8tvs|WI>d$mz2"uMoSON@7 .UuUK09 S\X$mz2~r6OC|f z٫qxGq- vM2g=9SjPs]O n`f]~r6O? 9oާ̀nOfkXp9ڎTԫ[gkp >Z7z_?u^y3!Xr$mz2~r6OoS 5k5=vT"eG^ZTۉujM[56uO?iM|nHJ\}WmZb۴A J" " Ѫ"Qz"<\)TݲtZ[L{j4=92 W˅*')ajTɪGeפY,5:x{6[- 5yk) o 1TCi'`=ETc=fzW֋)nh :J <[5v$$4ɋ. K,3ɮkzQc@I!EfTYغx֚7Fm  ..7W.k^""""==0t._@RcQqrIW'3I\ *w$T {$g#p|}~nO<@/!nSf+k{@+8f,2*ԑP&y78 R:3#'Ѧ5@G-k,KjҧRQaݲLEJ˪(9zN;mق\@\yU[y iSo;8ZoؽG')aCaH $rHgܰ)Wꢍ:MstDrQ_j䋕]_SQs֞pQN7{XƗ=$r]p,M'Ryn>Z9BՉ 2~pJyuڃAxu#;Ϙi'A*rF>!W+Kiaú N$U}2A7][p&Q8{hVT. 70Iig E#a|^0_[`KZZ5(sM 0 8MlXz4&=KeܕmW8w󔛴;"&LdOh7(OGCvLUH/*:&0.k_;$M#G [ڎMm&UĜNTTc5N?h:ZRZܧH q}.PaKhS8"$EO(=lF:H;s x#/\"-gz2Wci:&6?BD2r.ڼf8LF!}*N{i^@RU]L;-A H*+Pfu-P įb:8NVK`s5HnMN/!$K H91(eWqm28fyUF.l@vG=WaV&s5&}Z4`66ˆei㰴+pg>*I)0NQ*j[ U4psUI‘֊4rv L(ŒK+EMM]b"6xɎ::\M D +==6P(OM? -'b@Z.X%`(aXUnb7>^E_}<+\Rs=2r xjR(TV 8m?b`8@^U.B*ϩMg/NQNWaQ$Tt{$g+?PO eWS=01fz@>J<ؚMZuX\|eXm`gsu93FWݢDBþ_$~Rj".(UXQO]"$ܽ|HOwdT-@^@:ǹ]ʛ|bv8^þ_$~Rj|;G*/9BND9&:NcyklfwKwdT-O|HOEԣ5CEFb5u>W}LCj ۄ +C/?)St^SʼLa67 |Ys UQ _)] :$X*|;G*.1cNIY9x#߇|HOwdT-@^N*hɖ¡U^UZJg؏ܲR:OLLZ _)]'zW؎EL]Júm6do^þ_$~Rj"C=_nce*k8<8.χ|HOwdT-@^5:|D6bb:!۬C["";z~#?S/?)Sxnn]oא:YK";cLCp:/k/?)S>#?P>=/u*{qk=f3贲q i֊{?JZ.!mm*spvc˘ _)],zW^MШꇛa0Ex?J _)OPWe|;G*þ_$~Rj" An5^u.-y$n%{JZZyF8C=T䆏)f#_׵ZJmQiyPC@ޫ,`TNqM2#?S/?)SxNs\Y.`踵䎣v7Sʤqj\I=Vþ_$~RjKf"{ikTh!6PpSw̱Sw̺|HOwdT-@\bǫM2z/z./?)S>#?P?Sw̬ўnvm;-x^þ^$~Rj|;G*/ l{ KiWZC Un,| wdT-O|HOE 1*)S8~PsNcEx>#?S/?)Sx5\u 9y uxl}4WfЃ׉C{{JZZOO/ڤa@CD.G1c}G*smp1U2"#E|;G*.1cYu|;G*þ_$~Rj"SIr&aSh9u^þ_$~Rj"C=_n1ctJZPWd _)]þ^$~Rj|;G*.1cY)ud3e3"ZJ8Lq$5ٝϫ7su^þ_$~Rj|;G*/ l}2 )WiiZǂ`qqyXٸgy;G*þ^$~Rj"نk)Whx 0T I{_Jt9cN$AsAOSNpQT{ykG5rޡ7|˿ҾVT~ \2HluM'5|;G*/DNv tYCiYN f ZD|HOwdT-@^9u*c=f.(i u3/{JZGaAm7SXܘZ"~PS4@sZ@ wdT-O|HOEⶏ(b2ׇNkaD0P;j!׈ZJr=c\ MLc2"#DEPWd _)]þ_$~Rj|;G*.1c=C=_nAZJ _)Vz(l |} ~;׹ZJH112d#Um7Ӯ7&u ZJfLUZlZǂ:)\b!·NwdT-O|HOE沝v xE׭4|ڬSӀel{J_Lk8Jqc\9 i7"" Ӫ"챘k;.kg5a88:4ƝKu)K*4=ͮX*hU {!gr"(Q\ӷR3"Gr"V񍣉{\ʘ^t4S "H6큇9n)k[B_4?ggh44e+>?̺~E|"=RXƽsXeŤ4U^qj9 qo|BO+Hs8a]`)6qPUEfaYKmJ[1a%sUkM\Z@=GU׊fGdôgp]8RѧSmLĉG^BJiR)*4$ ёp-{6{&XKg#4jc)Ӳ_CsI}P²L3*dċNy]O$mh:GVmHP4EVFӵ"BZ׺_츴zJN":Ձ&@Sv齮v\ o(,5Cid /,b1n}7a^[M WɔD: Cfh0vl1U;q*ԩV q\J׀`Ay3[kiH";arkr%JU '":U+;b~5ۀQ e{܍V sa9("l u6aS H#joB'T84~ejsi~ $7ŗ}ڸN; 2 e2јJKc*aMZXvjnD6 9 .)za{i6Itu0XQB6 8I$.֜p*b(sX&% _2e 3wYc~ "J4߈j$4f\[4E & 4D;h"%fT2G k@#;*1u141T1U)Pvk\D< 2M;ֶq^RV8K6Z̠*=!r?!b0*H_<.$5 [@5i{%n5i{ּKK@#9 2]kYq*Tq4a#٦7Way!*T:͡Z&D gdEĻ YkMkZ@=F.ꘃSjs;ڎڳOGkQ\Gs!)dFEq_.}GV}:x;\ꅁv]O"BW2̵$@Xm kn,g@:/7 β/e'K&/%V"= X>M*%%܀#6&9KOKm~Jn98rn"ZZ~BQ`݊5)]/WrKNZ @Ѧ-9<35 v\Nj+;dP&ڠ/NkL cKrkA$LllocZu77i%C <[k7m .}VpbH.jLEi>6z*76G,czV=տ"10ki4ڦE&#r k0 &W?ͷѨ~9poy IGq/)sγiZ&F4[R5ڮ/hH#r"YU 'e$%Sv齮sH1WSsK=gүPԎ4O|g*Y_Lxym6"ME_(~Mzc?G|Ec(ԪX<0KZHy)ҩYւ]C rGb9{/ֶp#kvk̽seӻ!!sVSsI i$3Wcw71vgt+. aN:UWlND&J>-DyNzw6kL8:~s~3`wD*l=U &CZFzCR /8l~" ż82s , iniߵ 'gr*5\@5gSS 3n6^q 1]YRS pt^6Mykøh!y>~Q]l?W.e1sX%ŭ$:U+;bh.=u0\4q5[\7'ePm\_J}>ii $E3Zqe73i1W0 qcLw݊ ]!難x`A g1!W[m,k8CD)Tqh q/@OVPncSƞJ}l]A [4yU9kU9)LC \ p={ig@:+(ЪQiSuFLr]&bq8+Ԫ`귘D3d\G&U=6B-e6DfVހSBf1Ɨ8։'{mFӑZ{MpxWS{X於- ;XpR4j X8Y\la깔u*1 MFZ,qi81@\|Sַj=Tr',pSyi$tl~'[ Ɩ6 ָ 63[o(3I8:>->qѴ$'TE$D@Ԫ"Q[Tos?Eo1S)To"O1S([:3t¡k 3s._18nOWzZ^Y"*fCJkrU KaUx籮=+j`EVԤ׵r"9E_uVmܤΫ^kvZ嘚˚9ִH#q]ɔ׵znmC/!{ɔLk@i?؀|l5j6ݖHiuC=#ؿ/,c겍7[@LOFFsu+UCV!`s}l?/ߝy4k(U^%[p7r;݅`%|O/AX$gj+aik7|O/ɯ\\C(i6HȈIܻOKU j`EFW^^^[~t bko΀9:LGV>ι'l.A}jʘJxumMÁu@/UeWn)u ӭ9US Hߝ>rؿ)Acگ"WйsѾSɼDQxz5PC .s+~7~tE" r*7O\4ʍo_bj 3vi}iU8wyj r*7O\4ʍ^[扩s\1hiBysYv(b_Ϲ%'gt s+~7~t%߳MߝhQ~_K!O* \k06M93>z/K+~7~t%߳MߝhBJ5]q~"G?j6l%߳Mߝt~=8nv^^^[~t bko΀uRqnK]j*kQͦݖnpEߝ>ؿ/ױ"*)45;th<Azؿ^^[~tEC|gW'KQflf5\^^[~tEayKR Φʢ֛N,cXԘXL7- bkoΟy{_mGsX=hOʸN}76c|N bkoΟy{_mSF3}\;$ZGRCHĻ{K;#Akv/S//}:|@^5.VQV+In'99L`>W磟|RoG׷@XwF.W\|>3Fv.E/EO/EO/r3JNQkM۳N,ceJx4?Խ/ߝycFZTk+jsi8_S#^^^[~t bko΀?.GS%Ķ5ChjWs6"ߝYK~]eF8lzm'O *AF澁wܭ|F#JhX\^^[~tEYU!GtNyAS֟@0܎c%ߝ>ؿ/3ThkA- ݋BzZ^q0zEߝ>ؿ/+cvajW{2"6]qsE6 fݫ bkoΟy{_m븍\P`spąO'-O/륯*Ѭ6'OMt|Oߝ>ؿ.aOߝ>ؿ/)c0ja{)U ض0x_,Kkt=.K bkoΟy{_my;iÃkjh䀩XʸfYði`/ߝsM3h찒Ѹʷױ<ۨݗnZt= bkoΟy{_mCj0=jlOx^#=vb&߀/_Ck XJp4Wcv` h숈ժ"=wEzSV3tXyq EI{N޸GX9!V Iq_9̯Vi5J4Qi%{&D ٠.Nޒw=f!KRfu+i)}W Bf r^\ ;zI{8ӂ`EAνRK6<@]$=gX:/ciSRi-`vAzҜY~* ( D9YvRw;]qVhk0ݤ[YGҚ%)Р-MQ}9nEFf:&,w :u0Ɗwijvg[@1Q:z+~G|YϯbgTwΞQ:DEدLMz=R<07ŮY:Asobg:bgTwΨ폚"W_ʎױ_*;ZȀ}{?WtW_ʎֲ -^~={?Wugױ_*;O^~k""y']ގW5hq{KFW/د󮋒?N-}x\"W_ʎױ_*;ZȀ}{?WtW_ʎֲ -^~={?Wugױ_*;O^~k"-6& e<6Sr.5&!_.T$훞ps^ݟ{~3JW4"a`GX(DpQ]XֱQs $ֱb?g_gT&  $ֱb?g_gT& ckzmX9+k:?: U`uGAoѾk]_?obPΜv*ITwΞQ:9 -^~={?Wugױ_*;O^~k""W_ʎױ_*;ZȀ}{?WtW_ʎֲ -^~={?WukD96.2D:{?Wur_'9l+~G|دd@[>Q:z+~G|YϯbgTwΞQ:DEد3.ozG|QJ߶h^+Wٯp7z+~G|wF.}{?WtW_ʎֲ -^~={?Wugױ_*;O^~k""W_ʎױ_*;ZȀ}{?WtW_ʎֲ -^~YC5i^GoZJ?5?o"=:WUʯcy6k+~G|۩!C`\"W_ʎױ_*;ZȀ}{?WtW_ʎֲ -^~={?Wugױ_*;]v'\z!*lL!vXӛ$*y9r޽Q:z+~G|YϯbgTwΞQ:DEدbgTwεl+~G|دd@[>Q:z+~G|YϯbgTwν_GP gּ7l`?4TD@֪"U m&W$1wiޯDEH`jmX@nl?[ԳSK57`܃rSql.o>ʎ.7/*\99Z\\D9:/_ c18C)5j5fZx*aj;qyK1 \]0&lWudZ|2v`NdaXaچ!9a{Mje~/wZ5rх Ef۝R Ϥ|pLuà:ѹu4y' SaG{]?96hv 4l j9E GkCy.ٝ_<^Ln=;p; .g/Ldޥ[j8=ZNp ܇bq>bu[Aͧ^L+_LSQ}%G25N{mAa un =2 M-}<=OR6R a+Q^:(biujmv[~NHAXo<>(1ljfҩT;4l gUS21ԩc(ܹ7zY'b&9lUt.WxGN&> L]Ġ.&P4Øj)a tۓZ &;iqޤOL]?"@!}Oȯ .ϕ\9C Z ,'4t F?(a^ NZ8U ͻgj"s@y5!.g\b]L"Bq= e @(X zuۊpn6ODL=l 6bga/m)kd9W+1[Bʹ6 lGúS􅥭eٴ vXŒ.*Z+*P;A͸"2vdjBl=fdtL9-PVQ[Z6"Eh"FD(Su:ڽm\;0@@(3PQիihqk)E] NWJF@Ue΂Hg)\.TѩB*C͊F LDF55Cɭ-#y3.>j*U=}Q@^i* $ȖGj1>&گfh^ *ԦǴp>X.iֵv`4 .-\9`Pm\-mH}p/&Va*8xzSּj1`0 x粓9psE66; IRw/r2: kphgY@]5 U >*(!g:Ԑm&+Wqx7bY[ZuPׇOTڍ*M DQ p  pƊ$mڀa*Ǯ`6FG"^5[8Bꅔ0 Ӌ]iNd#ePSj"Iq2Z1u6^[f4RD*3.~/\UOs @^#v Q;5Mktw-SZ,RfW8@׹N"l#> r#_A%sCGcEGF'#vq;@̄EDZcM,MFm:r\Fc) ʽU*;hmp^U^VUO,eZ^ɧIhzXMR]_Șm=U`ٍ;T\RѲop}٩f4xu_NCk[a|3_Y*BC@X ^*#01Y!dE2`x؀9|5ϟƷy3@Sa ,4HaͽJɵCC!`ozk{?or"r7'UpsZ, v)LN9sץƷ9 /8rn5z{.~nȂNJ~bV #FEףϟƷ9 *@@"?ors@\.__rɼ*݊eo_sԃ-^_39gSi}/'~.aq4j8kv_^jn^! c"Tp?|6F(" c\.O7@'jn^! V?M"p?|6F(" c\.O7@'jn^clj I \ ]+]_?obmSP kw#ÂUM*AD3pzau ~Ѹ>Tp?"u ~Ѹ>Tp?"u ~Ѹ>Tp?"u ~Ѹ>Tp?"u ~Ѹ>Tp?"u ~Ѹ>Tp?"(~Mzq~Tp?"u ~Ѹ>Tp?"u ~Ѹ>Tp?"u ~Ѹ>Tp?"u ~Ѹ>Tp?"jn5|6F(:^uF7%H5(OM?}*oÌh1<4^jn@\.O7@'jn@\.O7@'jn@\.O7@'jn@\_7HTrjn]I^G0SSs&W lˑu ~Ѹ>Tp?"u ~Ѹ>Tp?"u ~Ѹ>Tp?"u ~Ѹ>Tp?"u ~Ѹ>Tp?"鱀^zn^#^_(ah f7i@p;QЪ"W V*l`G>K #٨K\[- "^yGpT(maR.l3QI;HO^QW٨h v'shM@H!3V~JTYԮNcv2AH9#RQ= -i ť)>ae99v6hn6Fe+>?̺~E|yzEP7jH9Lvb0c*EJn4 6\tZs({6oEz00l9<7dᚋ-v"9꿆2E6&Zd͠"}UYY2Wn^{e9ŌO't`0X؁UMeMBeh狯οU;+Ѥq")8S x;F ::,QmQO\kZLlZZ3E:۾TEEXk]W Cj{CLIiaxHPurRk*6ZcDIm/~AW)9;>)?dS hn]ϡN<5j4鴴Y"yT_CX26lPȄ='@7 .m} c>\+ 4w\. x7}6c)9E1Zoxpo <.Q}M~XƆsU\ֈh{&|_|> Ƿ+Tem;eݱ3dE"9"rF1ilkp{-w۬/yn0ñ2*1p`CMbfp(_a0hv iimB6VK1xmaQK}e=2H$[J"w )unfmQMCdZeTz-SK]-l$E_j䋕]W?! .UzF|u!P59Ɨ{B{]Qlv["QtZ^ a4tZC]^LuU䳏cY}(ШTXH$Ch9 .)mQ\BKU{KCԔ|Î >^}lEĮП7[9P(*2hh!ŭsR1qHb+rN3l!hiј܀^sXY9 "" ""b6>l[(`xȸ9.aIS\M:t>汥d&u (bjעGְz$0Ts/i\(ԧKÆ|l6O cy?V;ZeAEƢq;1xnTFm(SkaLAԕ;aM}\;ًkֺ*#e3u*yCronXnǢ&lq6ظDD]@a' l4O'{oko>0]!>VU^ݘ)1ðVLh8 # kh .\kvÞwiUnsN 5ͦI!m8\pjT]B#7Lm]sKIktIj@^W rEhmܶHZN?M arwF.3#xGu *jtZ_nr۩!C.QtXpcQt8͛[U)5\ڍkA@r@\.f;ݏniR,cd~ hoB1A=YۈuP`Ti;0%1"vI(bMA !ѝ:UمesR!˛y+~!Sr݂yE!غԘ:9#NR9r(z3N5Xt؀$D@DD@DY Ɔ 58Sg3CNA@\b.ΩB5Tspl5ؘڞ=hS PY u̠/"Ѫ"QKaߍ=ɰƞERwOrl;i(క hqL44Jq_R81]~e8Q5X]Na̓pW~a*SR h Ls0c]ې[|NmjBV=Ż/0CX~;1òkmI2`noO hScj\vF%oR*:;e!L /?)bؼM5:buW;h膃nWW\;MF:^[كw.#a8I«9s1UG=k}TCC6NPQf:e,2F?m74H10˶č;צ}6 i7-r6u 8W>mR"XEW6i+l/ ^(N2_RL%{0`0 <Q4"4y ,>ǫ p (qܛi@QE-~4&ÿ{-˧WǗ=6b1|P=ia.to|~Q̀(Wʴ!zH]JM' Oi;?#d oq_ +*tRnpk)_TzERvW8<s#֮r4Z#d oq_ +GVSub T`pk!`ђHqp6]^2VE2~r8/+=UTmKDt/w>T*rPY~s1w\?9[G˨#qNS}JZԘp鹢H$ Sw5꿐9Xq#dEOܛTԤuM:9+}?9[G59sU5MP 5~4 Bޒce}-kX0 r 9T~r8/~Q̀zS*pVj!l ZvZp -26w-VE2~r8/Hq؜;hAiuJmت x!S}'9ͬ)S,ج99WA`?(OVE2"𘺸Bd  .')+~jva/ oq_ /-z.[`(>05Ӳ9M7}i#4 oq_'+}[@7H13:tKA}7\v` EÜy~Q̟#dE?9[GA`?(@^Z7qMQYa=4+?#d oq_ *r2)-se%;DguK]:+9֨ցV6͑b oq_'+}Mv Ãrn9ɘ+59R,8B*nki 2oUr8/~Q̀""gQi #YY&-kVu**U"Rq_-VE2~r8/ouOD=2cNW}{aۅk3Pt"ar#dE[ lwc.2)G~Q̟#dEr%)>vp4k֥vy{V+}?9[GG6»)<2a$GHp5ǫ@ `SZ#d oq_ *+blEb_ak$Xn\ae:THNWfQ oq_,9T9q#2"867ˮH W*-j( Ss` hVE2"z#d oq_ /-A`?(OVE2"ׯVb4~E,i?VΊ#d oq_ *ؗ;!9!!nUWlk[XQ3(|ص9[GA`?(@[ 17XqIsEQ%=# V5 `nǫٟk oq_'+}[KaB vZƊa T~r8/~Q̀ǥ8էQpm&9h#!sfJ}%23h{M@s$vCz oq_'+}m3lPUhN{ LīLY .sUQ.i$.I9[GE:S]n!u'L /"Ҫ"yڟ+O@Vs?SDEg;SDi9D{xڕ9QMu,zTsa7 /?SޕWQ,acZe ^3ܥ)Uts1؉@];ScOX(;u0Sip$:zUe&TpSh%^\gj~8s?W Y:T8h}2Tp><8lZuca_".v;SqoI1Fs}Nk(RsՄ=zʕRgW`eJ5L수%{J"9ڟ)qPDE>v;SVǔqxG՝Jm _1]˿gU/{`2EKtc|u}(٫ML<!yֿpzv o/gۋ,=bv%H̛ -Ovf&;7u\ֳ]xIp =YGEc_..oL]G,N'/vh~ƛFÆz@^=?H}')ļöY0wmO5ya-胸zqX/,WxT&* /pn/nDѥ"*O)a<~hUޓDֵW ;7]/\XSu ujžU[p -nQĺ(!N ΢싊.!;SZ80xbYGoDͬ]ˁ u[Q]˿gU/>j(_˿gU)  =@/:<}z$,4{}ɂZFF]g/Ůk  u='9͡#i7[kM8luqjR1My GA26MWORlb*6:p)mH:yҾ_#hc+Dݖj'q8Q0z+<Šam&ʅ{H/L,bJ8ǶSO͠on,\Ԁ_g'+W@1΀<i˨ƉW{I*PpIzG$Qb*vVO~ q~CnT98c0ܦiUR8s6Hz49_PYTh$hI@^{'Wbn0[ 'مg/mnVۡ^#q4zJ* 'NT:s++a)4XԦ!ob]^ŴV79E*c+m6 _p$ck uv~JqHSv"ssyt8r6#x0R{۪դwE036xJe؜CMObY_k-b=Y*<wll/9p8cRjxඥ79?hl$^%c=gZq(rF%8ZMn@E|.߳i>9 /{w.WO̟ w~e"^zE\K^hή*EL!sjM,̰dƆ]:̮gTqk18KZ o 5ly[SaJ9ͦ׹Z\@^\]l*pU150Z2/EI",uAXvDP>rhq 9{a{W 8& 6$X6eH#5s%통ȁO^z/>Q1uٴ%MّH=%Y9C[$ yܞyeR(ԨYKD0`ӊ#[؜-VmLy \-V̑Z"H"KѬ-Tk[hm@61~Ϋ^-S}k|mq_˿gU+>zE_3b%sꂐ¶}KTpݵ6KHxDP8l #4Z̓{=;0~FsסSRi?`lݻԫ?0 5 7;iH&l/8ck[u1y+K$Sw ׬ja𘺎 AtiŸFIf@+YQSiWZڎMˈ`zOi]Z[ٕO kj]~h ;f%t|KG)46ԧMlI3.ZVy>NؙϴեKHWnԧOv[. 9jW?~Ϋ[>m#j~ΫOu_?2Q{ w~d_˿gU/~ΫV|(S}n716gt.uwW~pcp< 4ES:Χ-n6? }#mOZl8~D*BTe:W]V6aQ2[HX~+XyP6+ni1hu}"#L"{Z}$# Ʌ#6e{Ln"|mj؂m4aSגIG?R\3vA!SdB4 K#7.`46Hxٲ/I!&݊:nhٙb%t.33jLv!5H蛉UV8KM|p$E/L}!^OjpاҦ)Q!0rԮs.WO̷}<6P# @]/J="HP$1 , f2L 'o"VapOsYLs;[LhL[jr:ickRzM4.i9xEH}'5.s 86we'yXa,;ٲ=k9MO3+T{YRXjtjO>+C*xX%e o(]OMnk?Y Qw~c8K 6n8BjfbKy'!2hSmsO_ZVDyhakA "@^+}$u6q{=Ko2CT15%ױ-6&5qޣbjիmLFM#-$buT.cjT9Vv0_r?ܻu_?2|.߳i_˿gU']:x(u_?2Q*]qL-$!svTIE@T1oĝ3@^M?J="dKZyezO)W`<O MgF2f} dd UTZxuSUԛNikmiEH&~#y-NjzK%Tbd7dZNWXUP},[k hn#1\81T^Cm׋hg>is+\H%Hw= m|McB!%͆ݳ 4K^(ʓLժLH7r=f6*AlK\ :"Fd(舀Ӫ"Nܛ'q[wKd=ɲw'zIހNܵG&aE'vU\KNd^Nx)ՙ-pp;'Yo$ef٧:dI;Ikp { ݃&)70s0u0vnX2oR$I;9>7SNEJ,-=p^;=mJb*M!ܘo]|'z"Ϣϊ M;3g̍P4DRknw^'z"҃$ǹnޒw-(;rA{'z"}:R!챎sj 9'f*~Sw̿FE͘Le75Uiȋ-Z5j{eŇٶ" /Ξ.jvo6imak @Vl-iɆ$@@_yRTskbT; 6>PXoTi(|ԍ+p"Lo-eo5m,$܎W%tWo,;{ C0D/@L@_߂;LeQ~T~Q~Tla)`*fVQ9v4>+T9TTwAר2vYmNU(Wu C8SUԍv͇ Ej\BX.tmY0"E he@Lx-峊z*l!}@@_b-*:ZrK:.Oq_?)_"8ي-5^VҫFNacX>K=@~#MZ͢]la1ps^"Itͧ5 |+qvjs"6@U Qs[\d1ͭ~SW\b1 R{9E]KTiUOk+jL􋳓u |cyspd8˘WOn䀀8+b7|8ي/"O ԧJpcdElW,*TTsK $E9FkiCc<}pklp0<"M2X8f?# psi:J /w.5 pI&3.'91*U9GjQ!FBvg}@@_ᙬ5Atܢ-][s;;{ؾ /v!ak媎e's4.=._q_?)_ /ϸɥ +5a Tq4.}qd1/U@@_jj*ը+fŎel9GpUkR!ًW$Eg!t+cXy.S\cvZLُ | +ԤkI͒]A^+]ވaͼ0KvIvN+"8ي'f*~Sw̿G@Hf*~Sw̞M2 />M28X4)?psi /tpb~'9(|?TuwQ OF}Z_XQuSytxgl֧wmmml:v ~xs9Ęŵ^.ۊʵB>stream endstream endobj 1811 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 9 0 0 9 70.8661 730.4829 Tm (\020\004\206\f\t\204\004 2.)Tj 0 0 0 1 k /GS1 gs /T1_1 1 Tf ( \222\n\032\032\031\023\002\203\025\n\021\021\026\002 \003\026\024\032\025\ \203\026)Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 0 -1.2 TD [(T)48(able 2)16(.)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf [( Cor)-15.9(relation matr)-36.9(ix)]TJ ET q /GS0 gs 221.1023475 0 0 212.6999699 70.8661504 496.4790116 cm /Im0 Do Q q /GS0 gs 422.3165792 0 0 414.1809118 70.8661641 80.4641163 cm /Im1 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\033\030\031\030\213\b)-20.9(\035\231\213\233\t \021\032)50(\b)42(\032\231\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj -51.938 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 23, \023\0221)69(, 202)69(4)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 23, \023\0221)69(, 202)69(4)]TJ /T1_3 1 Tf 25 0 0 25 28.19 56.0378 Tm (78)Tj ET endstream endobj 1812 0 obj <>stream Adobed     '$''''$25552;;;;;;;;;;   ####''',,,   ####''',,,   ####''',,,""  8G!1"A2Qa#BRqrb$3CS %&'()*456789:DEFGHIJTUVWXYZcdefghijstuvwxyz!1A"Qaq2BRbr #$%&'()*3456789:CDEFGHIJSTUVWXYZcdefghijstuvwxyz?h0Q@EPQEQEQ@EPQEQEQ@EPQEQEQ@EPQEQEQ@EPQES7^3xA>S2d}8UZnMt fQ(۰Š!9F-ԦIۗN0.袊@QEQ@EPQEQEQ@EPh0Q@EPQEQEQ@EPQEQEc r)S%Cwd9U r}"hY׹pƏlXќԢyHź-p+2ī; $ʻC-~P %V;!샕&VǕѹE]x:g~<6:xljQ+tQEX(( (((( (h0Q@EPQEQEQ@EPQEQE 1X$a '^^QϚAnvV%cw cN ;,dn,Ws+ʼ ^mr'˿NgCcBU E|j5VmɨuLag(=X$w=J}iqY6=I$~I5&g.+ě\GD[Y$Pk JKjʊ$kswg;sU:H/{K]B"Ez!pr7ϧ_kwMeO:*NҩlMF9&l!R]7 q +_NvtسuQM]QtuuQEIQEQ@WCt jm2 heHg,5Q75+}H>\Q\͓?fÜYJ5o4`Qd}lX xqtGz%Ip(]*ssC3n G''#L7\KM3&@ېz4iIj8)AϿ}@ז[3o+!2઱S+KꑇkĄsbIp$"DUe1}-}9KnӯBM97#=M4Q,J F\l;=ڻ_?w Y0,IQNNUnIU#3F{F.„8=JK\G p%hܯr餍#2@9R-mZʓI`pFA#PH< df;+bC;G匑 PJ>1z y'o5^Z>:I.Ͻޓ>7Te)(7)4Jd|\]rƄ 8>TmnPn<6y]ht#:J/*$ܝ_*NJʗ҈N,V鎠뚿/}Z^*xY29u P BYͼ27$=C6U3Kul[T#=yl]neDq%֛ ҄W!cj!˕1S/ 6Wwv/_=NㅶO2qQo"5y&BU@rjf[<]SV9%*QUwor@/K8#Ȧ^$6>EyI$nP;d{ti=b;vP!TѨ=8PI=̜82I>l IURץ-kE1^Uu%FUJG-6=f}ݙy0r3dL/~n,ȁ1.޵H1d+9K4Z<^5pǦ4MwokÞ"e .ɕQޑZo,ko{4vG$#N1dUv2Ϛ' f 6\ן*AEGm4XQinGP9P Hl UC;Od%M𺺜ᔆ_N[X) -)rJ(㏇\*ϠQu^}#á:Jv]R5xM%O61=̙a@vݚ`,(Pt's72XKaUNXL\)]$g(c$ziȻu#A˂N.VtJI(ƊM5 {<٤D{{HܟjOlݝeʙK1/ϷU,aO$6GÑ-l7s`T TcDcۨT͇'\VfnwM::(8@(+K@ct)eL@ vI`7Ps;OtqܪYzSuZ+DP2,%=_Q4NJ=PAi4w4%THFGA~jy!Py(S5iNXk~3.31eGS[jPėr?*<=&w95t!k!#isΨim^PLeϰь@략)'-+KvF&|^ j9ZQW|7& 7R7R r:wW.xCo-)3 qPLϕt sdp3\K[XL: DT cn.{-G|}):(Jxf)[R:((<*]_P~U>uq"[܏*':a6l]G< ߵj*FES?5\ӸBO؟1#ݫ;{式crj8_#ܾ#ͣ9P6y!^T,EPQEh0Q@EPQEQEQ@EPQET5׺1pNA@=HJ2Mfmӥ-YEr\UZE}m:Lb։jңn[J`NAt tڝ7VSK$㗘6+J4XzH$xJ1hӢ\T11KjS[tlu:f Ta ̜T/3]Nve P@㉫eU422mn*W[>zt xSMZAqZEA6-e x 2 k{1 qpF;HlgqҭH QW->[j rNYя. Тq%YblG jeoGQIw &SA,눃Cz; T3r IbN5A{|͚]3d*A#rKM2 yWc"zIP}8<#Z7D{n+AG4SMÀ{ӫ˥0'QE'Q@O/okY;A'JV+>mH]1SAoPjV{oe ™7DW{3 k};x6uf6 pZZ5E–XҍzˉuԲnt\JBz<j;Y-&*#>fMzv d qҩmVC,'"BH#O\Vk#g„q6Y7,ՌjҊOkzh J@檋MnWl8rؒ)&E~;y1VTݛb,:Ibh/=跍բnU!"瘣eGέ1T\עJ2jVUQV9(3}s%C άuτ:'1_;Θk{[<|_ p}أ|W,Aٚjv~/RO3ͼ [C,T r﯄؟5xGW`vqGq}5x}B+Y4ڭ;m kDƮ kve]$NY]ItjJK AIs(SZj[`ÓJRUiBr1,h(i$!&((h0Q@EPQEQEQ@EPQEyUVNenb3cs3A"y@LkKfѥHBnF 0Q.6t~MRSPuZ}%NCcĄ*Í%9lj^рب!@cү`KK\Lf(cG wb.$P<0psE__ݕ #Ạv 2ϾrQt|zZσ\^TaE*9ׄKW@aYR%Yvs*-5S 1˛cwSӢkY6a 5k lX3< t.9*esS-S[p#=iq.=KCͿ a3|#:ؔ0|hǵStĬ5R$@n᠊e_`2:H9'OJ=!ɓZ]M^!ƹiMҹ q}D'm2,oy^lնOJ68};s\Bum HQRLbG?8:ܷImh)yJP@ {o+)KjXnsSgc%.22.d0wL$d1:L-&1? vߡwmg}jtw o]4'CIaIJJM:.7iU^fHIbN}'q*7]خOym")n.ܱvY,[Ia>5u,SPV%7޻|wWIB#ouE r3QgWg̺d󋂏-mYh$M*qq V/!6v1F\Ф89b@ Qs818k⩒B# Oe(AUrۥEs-diϤm+N=Gx{U!WDUIU tQEIQE== J?0ۨv%%L*ƥ>l9bHf++B.!كX{6A-h( ʂ\qy5{u7fveN2Sp$ӬL| hH̬B.neTaqtzE[VS35ui\>Jm!϶*=1ʌTFYOstB6}`8yԚFvuDAc 8[qc`'ko,- ?"!.G'8>Q^x!cikv*i=qk6׾3k/lw,dT`E^x)-3U|d:֧Cj۶\iŔpoIS6pa8(YkG҉jh~O#ܾ2mO#0 7w3I.mMYn_]$ 'ե }js.B\͏,g9Iѥ%®暵K'N}qO*ib1n(EPh0Q@EPQEQEQ@EPQEIQ&BGvƭ8,2p3& 3Opb2F rUUM_uؤ㚐ŗ 4e[:5FKUzu #2)Q`U+[ys=J#DɴH5w0 0zUE vx{Ǜv?kS&ik|QQKMu 亍(I,po=բI$P-ѥ4d+h IF(d-Mcw=tw4Iv#ç\Ok$a8;AGq uj_QsS^$o–]sƩq*:j(pQEqsRpI:֤"A&)a9nHGQLk }U+qi4H wKKyD שؕ(*$f ͍źS,.APӸzy4]#mJ8)IJ^-MyX-m =Ar+aGW-,k==,dy P lr0sK'I$mjPWvxhXKtDXW#& 8+XbVީ(aЀrn'bFٺI K~+8#UTPz jU߻OʱN1O~jF7v& TnnU K(w#2rZ".Q:$QN,p2q֩nK&s#IҠOUzJ$I<ɨntK'&P\cT"q*]( (KIųu\ iĴ$]3v_r1=U{pi4tA5S:o -OSa8 zu~gxX\h`M'GdI/g r*mo!4(ʞƺm;#=I>jqd+ٹv'INyj4U>.wnl,eN5MeRn)F+i"J`z2Jmm-0.˳c0S'$y[qTtW(@.uO,b {t3ja /1Ls#\Ys=q<by]+[7 IA!hz'U.#kͻ%nI`)> ms?gj^]]IՌ͸Tʥ+*`@ V|ﭽ5ZWL>]]Յ=8\YEK4j-Rgb)*uGuJ'#o`)5X^ +']wԡҢd(YeAǷMhz]M[3R2 p9WF_iO# {x vZ>Wbio[ ә.f9|tԼ:w7]}uФ,9]ZiBq ⤦8JuUhhpx1mܸq}xڶM``)emJN2Š(QEh0Q@EPQEQEQ@EPQEppO[ՔB:z]Y} mMKQf۴Uۺ}`G4Lݨ㟈1哞UGb ]v(1H! `23uQ5` 4j)(ˉUhK^ *V[Z^Q7@IK`0=9k Ms-ؒA:ˁ0lǀH殪׈-~< *tշۺ'mÔTg)r# uVU[Kp\Nx ȕ@푦hT< $rv{w/"*!˥. yIr2v<TUHݥVg,HM.ٕDkƀET`S7v{|jd~v`\fkK6޻lgڡn,Cey 4.p7;lGY5ak;e58֚::ӔllZBI(U4oWF5sXalyy$ZI^"%ߛSt=Q5;(gFٙ;;ε(-B9Q8bd^R=}uToZݵ]q' FmN9SoVn2to;jUKkfpҋ$a09kw[!ã'Z8ƒS}Up#%鸆Ҭ)Ps§k\[jJ(e =!I5IX*@'q8`}qVa܄pYr:KrzۈX04x1RRfRZRX K9b7Ux}_E-8UvM|K4fV#"po?.l~*MD$Ba_kEWxHeb]jMIZ%bl3(uZ):I$ZzkpZM%u3!n2RUhuN &E1/ǎԹ T3O1{r~gT r!^.ٷo[Sٺӭ&6r4pp`G2ATz$:W2:UWjNZͧH9Q):C3T[OKo5.;`g5^^-Gt#aNĞIk6]r$#Ϛu{8(#ok3*$rS7zU]H9JttTVրZ|V yҕ9vv8cu(Mɸh.TNʥV*]-~ 2ۚYho,{6⭎X׳69hyw5EvkcXYdsuˮ}fvYK**3Θխ*֗ KnțOZҦL<+x%hs,R6B덣c"e"$v% c"|{f pǑVH\(6#oK8^y 7#k'iqۣ͉D*nPi*[KOM-ަ q^<$"=Uء7WKpCFXNGB{PۛIu;#I3Le&a8}v'?5]+ YppP׽5,l&CN-$֎+Z,j)gpTFW""n߷5/=V #g&YlX'X=TVi9R]ͭwrЭotu#0 v ]`equuĘip|릏o vh w#Αu飮]&#oqîne(ݲ+M//P̎Zݭ6 \վZt J9g$gա}F/7L\enJhź4qc6|Eg]&|*w"tR`R~.UYZ X>e,/>gؔ!;ۓv-.=HFLBTHa=׃h}?gj=zgl1ӷ#a7XG->ܔkF.UƏM/w.t,iY!HrTV' `纤Z5\3̣wh@cT*jjWW^2xl ~ia,p*6YF\iԝDR8OŞ$x*Q@h0Q@EPQEQEQ@EPQEyUV^6æKl%̌p =)Ix$\EhDs7ysx{iY*ARy$ңjj3YSnYTWqRi΀kY^9]$a.R+jW>Y2Cc&t]Y[ ۞X JtSrљ{qp 20AחVjwq#%,'*gCk^K aF}AP<}1Qb嗑ȪRk˙ 'A!W/ Ct'S. ,1:8POr;VicVi8O](U}NhPhp9tmj{n{`#>W[$MS]m\El*m]uxE}4ȶKT֯qPXqœK,ZtR4BY  Pm!y5Z2NKFs'4UW׳LPxx}IzVM+hH)|"W \%0KN*hUY;{G֥(9^ƕ6c%`V\Z_J)m#ɴA\gR=Vλ=zclÆᇑs]7NɮtRibSnade|X:L$͉I ;;7>@^Xs' }R(^UNWi>[@7q[ݳB%C 猃QtR}6:U-6RQqI6Vy;]sCvF rF9VZ^xۋw428rw"1s$:h)eycfjʭڥjjRG*,@gؔ/>gؔ+Dʫ|DʡZ.co3˰G1ӷy#(EPQEh0Q@EPQEQEQ@EPQEy\k,5Gt֬l*Uspq]]@j]:Ʊ$dKvIHϋB@N6Ϋ*VH˰zUNJrxJqsS}Eett.#J6E.@q{_;".VL$ui-ŗ2H6 . 0bvv2G*֚K؅bX"`v$Ϟv:6,,Lg<,ьZvri,^@^MA-홓,18$w9⫼%!DP 26$0IT}N)&ٖb c)P㵟x"ˁ&N"1]jV.E.3x&a-όZ,w Z[*\v:w4x\׎l(E#׭D=3[XǶ5 JK.ThkXmfkv^ XBdpz R;X8E*q`UcOFs ȓ019M:eN ))_Q|Pp15L"'^oWZBm7#f[nlfueSnh?&KhH^G:$@#.`Nzmbc+"N C Π[wq+\OBxI,Qm(HWi#>zu:(Ljm6ZeQ`\ii%zvTnaAR:1T}G}r8,U':6 FWj^Fbq.8e>zm?Y-mC[;FG%.~OR5>J>M)NqMѻ]"i8@똋NXYPy,m˒{[G4Ql^;ʄ#k.r[ $gD$r4Sck bbd(%N+zU=q` $-ğ~hms"*9 uΝ^qnf?C&*ʫ4ӍKT,2M%aaGfH l˰c);\oh}ԿYP!к4UZ/UU/ӷ#t뫧-ng&PHX03{Wt #Os񼪒UI2@Sj[M**Qivr^z.<8VHJX9;מs:^;r "w")A.^jt[u`Lg$ $k֥ҰںAQX\),FJFT#o62nR+7@A ί,,cFiGi%uc* o}wXӚկ?\pl<UM_.UgiST՝lٙb. C<ͱ,}~(,񷋇Ƃ Irʯi5 WU& 8< YwV UXXE*%YIoiT'[υFNj)87[%G}x6p@gPK$"mF#8*^.2]KdiYQ@8`&IqSuk[hvz,ܑy)Vx3;DvOq5oY8Ա9&I֎֦uĺQP%$%5yUiQ'{u—R48ʫ` 2A֩=x^NSch Qnbƣwokn{!H:ve]4ٮniH !PfԪ{6HϨ%HԤDJTUMkV蝀ePѺH+˘#dyF2vM{T}w-r$XYVQ˚5'U[ڭ̷Q2 jI=iS[]eyDer/Rz gU*{^4T mSr̔b#SMFeUhUx܊q"D,NH$T>sLmWN ³0#ʦ*k8 4]:sPMC%Z.׉ "FW1qd,%چ&A>Xj6Mmsm2% SvR?ʚN2Ihzu.WIN*VIU:ƙttN[]%㶻ᘲmz)zŕilPIR&B8 |aMx'RH M;'^+h&(:EFQ0"o׾y i55If'%#=8띻_8ϒiJqѩ(1$ʞV 3 PI1*lbg )R!%x?ʚΠ*9{Z"x}ֱN{`QťkqZځlE&_h+9uSvc&cW!f\|)\aMxgU2@OSD /pRiM{`@moKY-cHp}^薺-oKȧYK4}qaMxgUpƚ%G^4'rAmFP!_hvח7{{%`A]?Sҳi4[wc3Wj&je@e.=g4Wh}?gj$I8'Sx33ܗ`؀/l2hXO I fXģnJWiZ*+#:|rv=($Ӎutt1-I9< :ҕoJ:ԸGI5Ь2= Z&^d~YⷒHHCȫn5|gȻ:_}@4d\*$Vie  -F.Hܼg*obdpN@S$)@2+nfQIfN&={0 M)-]'H^x̒8<˖jtT_^„F;j&ΏݚninxXjMywqo$Gl6UF;sKk rLfa*{Mk9.asqP6m"eE>4YBYT#үkb熰b$TpӜ~5a[ىpI-Ho!'#[OskK,62^UK/2ah[*1*^6~H#DN3̒zŻWztN^eVlmKG+[JT k|?nn5Hp3{/04QR|r|hiɳ٤4+E(mQq1qUTS݊Y8$2SַK;_{?GъY;FM14Zq_PoLwD{IlgR^xl$(I;dz{TD;֎qHd# ׋4*0R`0;쏢%WW۩1r{un4H>]U țRےMgQV83 H坚)딶@0#M6f 6qjáҜ.)x[S`;$d*9R-.G ik$#hQ;s*UMej=q$dH%x/ďLJe ;el]mcՏZې6}*4q%8ʑZޠ=QZPlSs‹\O ؞G'X^QNogVLQea0Ag^N|_|n]9SqiFSVuG_|n_MG[,i*.vPg9Ǧ cESlOQRAiNS);6|_hJ8KE9Is&((h0 _=vsk2D cTkc,x/Sʒ2F˙'UQh2mm;'|vĹ(sUuN;鶺ëe2MJ> K,3pL&ܸ4{CJ&$]6#+q]IZesq(Ȓ3n# yehbKW ' .g>*UR{ڧ'gSlOY,ŤE&ۥ@)EHUD1[NJm~ `In7D&n؇nM.;Ij sx5umQܳۤr)HBg*9 Om|&8; m9QJM5&ܭW*$.bmgKKuyYIw>pIϢf[O -VbZ>+X_5+L䱼yƑXbT8 '?=:S iW֫pbnmqVU$OsCKIVnjjZRkcO$9fAR|jOȲ"p$U/76A y'E-q::,PbrW Uu}A#+ȒFRSq%Wp1UYJeUֽ:{;C,JYproK5:Z5OVrEn AnXv}i`;*Q: dqdvHYdH pC"qw1z-:╽--1!9F}tKMi]D7^ i$GRU+_[#Y⍎;Gۿ/=Z ;oy1#+'{U|-x)Y5I.3v|ifץȸqɣy'͍Hi}hkRvBXwZi};OrS8pU:K=><Ngi0m wRA4ԳAڮ9cSMnk8""+x&aOUdb?̶*M{HmVaH' ZDǖ@|zR#C!GA79P"7њgJDaȇE%BIi*8"F*j2qTp1hw[5k t^I4Uayqʩշ<yD3,"y-ME %i@MaW]ՐEnyE\ 1)1UH2+!`3ם/^BVn`*"7c<#IJ15y `\sw55dehUM\hQZPp[m3LJ<} /o\Ԑ?m),o,anSrkH(?:fj"W&#˜]7f{by>'/8>Q]5fJg m?S{c$<Nu-1rϝ'g|n_MG+wQEj]o[Ǩj14n99IV5:|O{T8Mydը* NY[NjJMX8J*2juI(Q@h0Q@^1ڥ`:EZE+Ëc$Y6*@bgNc2מ/ɸFhmӟ%&)EF�㚉*IRk{,wv$q(h= 0Kr};48M[o8p*& ?% `eVh$(TjGë+7e%Fyu^:;"#)):JBq\U[@/A LU"l`@]RL P.Vw v 6\s86 ws*7U]$s5\",tۿ=ԗsINN1SZ.}c'oV#,Q$Hw*Đroop?4o;.}IG'ryAg@R{ċ/)$|hǢdcm$`:1I!oH*"R'xJ*jQg*.eOu%@<ƉD2KpUpyKSp:-|t y'0Yzyxd)Tp+7@YN`P*3$w$#x'6(T].1=I1ResrR!x0,~)8r{%檥)~?rkKMq#p<$YA x6T4΍,{H>WCvj [ 9uWۮߏAQļ˜͎5=|3Gы_G9)e zl_" Ǣ?X!HKPL2nxL ooٚk-k5ήVw>{n2tG6 5̜lɫҶUhtwyqZ^< o$(I@#Hդw<6j:׉[Ku3G$W$>WAENjW)tD=U(G4Rk4S]Z[,:DSRe7J$OQE@(h0jz]5-Cەئ3" g>zi|(UŃOp^g5柣!-%xё s&6V$>)iD 3yҏu(~m鹟%cr2y3AI99۫/ j 0KdH2hCe] 0|Ry1m1 CύrAqelȷI(h!jV'x{i)&,$&ݚ0L{BYjΩ>4㈅IF0XJY2x'eMRMl7ž{  S ːOeNw,.᷶A"dveQԗϻm6sk}^@bU!U9IIӎ_<#4m9$7'HŦWi[j7j6xJI 26vE.Qt(br 呣\i/9(오y};Jn4)X,ΊA`s\b$uؕ4`2zSXX+6U]jdxt&L{)u/lyi }^OrRUTE!?w6'{Ԇ#i]hnT\!LAIH{LZ: j%Z[Rj\; )`ހ`WsϠ6"X-`E.xuizr~Z뾀tOu*4NrHRV$E=ēҗ$#*Z_R%LΚnO0h`;|qO acI11ZB]h^0S>@=2;Iv'`-AS*WS8ztZ ;9fsyj"if \ wU0>Fk9Xi۵ >*xگL(_v}8?*(jkj{ȸ^Cp=iB'b0UP=DȜ&<58va("c R@<"0|r @"T) y"6Pȯ"A"0 6!c|q)PG?>I1"DmJu:wwϵ^dx_h~{MC*c^ \mAPĜ^q~*Z>#] ;6ty{N7mw -=~jڪ<WAٍ[ZsOuywsN#޾c (Q@EPh0Q@EPQE"i02#Fb^C5_iؕU ʤ13["1 A"+߃ +qsopXepbw>UkmCY*oBԧp5L]iʟYJӷZ{6J4V#۪fawKUk@,v#pux >iJ34Ωu2AϦu>.ni]qhV7m |~m ,TZULF vG(ŢzRSW6+C 4nXȐ;9KtY@p6I'2 V*+rz?W1, ey- =#[yPMP??׏*v8 䞴̶ѡ'n]>yt4.:"M+wjCM {(D*,3 l9P95e' 7&J(ΘN=؆>1G?46>oop?5c n⏍:?)-f]$S|~ҡV&j*]mpKH,{ɯdHYH.$n,dv{4qg;]2}9NUip"*&k[p I[nFt7*Ҍ`b6֮rH$R8} I>t XGJ 1m8Qҗ=6V<nb1/dy"؊܊R0VʏcNpb"ߡ$Ӵ$8Q|Z_uݞ]hC[$򿢧?׿(H AUJkm+AUvLՋWfbsxE6^tNfi> hVpd e&hNUAȳE,ª] "E; =+U 2q+p4v&:ʽ5pkZZkM妇8BObvw̪mGwZkWȕ_\IBm⊡Dž5 '%X:kI*:r{M9xֳ3& *taSH[N".#MnaP5U$s=:]ALmlɞ$e!~ W)~}:Tb6ܣ%XɬUjZ'j*3.Yh^nz!ێc$W'Z6Bă XjYѪE:D^E(h0Q@U;?\JUw!¬-Z9 C23΋SvV凋9ҰpK3\,ꩺۀ:ݐ۷'60vvJV*IFdhrdTV-ʤ],ފGR[MWR)f6aTܸH'pQ)$p9u 1Cr"vUo/ [\GwoY*\85VR D%"%$*>iZ%M8G:3%=lꛖ7GXxĄV5\M[kH|^n o,(9'8 qs~7Npc2s^7bM +NXSX4K=ا(@ M ϕz_>;D5lF)}E 7\|œ59o$z>korqPQTQ`iĆ2I>[쏦 M;^Ҽw9e_[ $asbHR(HI &.28? T^03f;)f૶kI$좶wqqy3T̩shzU_x>;M)ƌs@(R~X4Р >n,E ( 1RVj[Ic&8LA==iP=)2.vi^RX=kL'? {4m"Gu&5b(Z܊>\jQ m5,2y N>9eTSTSvFߗ,cDrbXv 9ϲ>PHX IG!7^yF,@~+ܙ9'T`{N>9>n|h9P\LjF}wROu=Mͱ9@Yc[j/So_ ]Q~*}ruysV/xŝ؋ĦN՟1%]e@jϘW,A~SxZJby >bn% Q||ߒ"j><(((h0 uD6<8lr@ J_ڽzn"@<NQLs0ZE"|f{U\ZUzHHcU擔 IUs[]Ayݷ!fPpG5%O_Hkkm6mde$ =ԙ.c7&R|ug>Jui6j\NRi6WjHpHxQ %z . _,K{ 3p{4< +I\(lcRt_Nԅs,[*'XqxWz`QUFnk,*€Ndwjnbc`\]UR}k/V) >&$߈rk)^juq׬/H#t")01fZż24s7`ǜ꫚JNijY>lfͣZ=k{\c]GL3b4:e,#3=Mywwv2WHӔĻ$KrOQdiWΤ"˾*m#yIU^,%(\]j/lm"ppK8$s uhzf]^:pHG#NC7SY4uo`ž+2B25kZg[w{)ݟeJ7ϟ=~KI 9Z>6/ϟo?錙7I:Ir׏Z)͓|^,Ѐ%=h^~|Q?Gъr]%ީOj#IxkꞴz$TE@_?a .Rc{#ND>k>f4a]&9d>~)]zyY5|&jxX'#,*L֊6iA)(8H'uypJqo]kEF{|@; ɵ{dks!*GƊdN f4ŽP 9Q$mqTcT}d9zsd>~(() 5Sӵ%snOSolENP2O{eQubW=|9sXů[?kgĖN%gΘFGcQfwڵak.辇el`BA+."8=>5}.ŕR}_MGǟ)=Chh<؋bo>; *SJZQ7Ҵ>. ҏ5BdWRE8%p<__p. Ln򲪔h\(@K C=54Z^ôԫZPD#FP1c1rjG*F{XxPʰ8Q<ՕEd9ETQEh0 ȃҒbm˥. ΙA4J$uAEK))ێ|BIUy7a\_ wjetĒIK.@$PiCfÜ0T%$PtkZs6mfܑϻ=ԻF[ n|.fhHn- ҵŭwK. }RKWUjS}=5ec)b5:I'zIQjhL`,Ki%K9-hgԵ ,54D {xV\>;#G#+|7Xv-6&qUxJѶLmm(Y*lC0kԮn@QH gT'3馵-+;ehTbsJ\kbYS\,9U[vaRAP00@bh!qVv#oNU66d$s!#,;syU\sB*bJ'qVJJ7]KEUW3jN:Ѱ:/6Bo5BET# sRc" Q06^^nBomY#( ve$94+v3HbcA4[ ?ZUogliaKXXxqtmtD]pDwOJϳOo׫|?n*%<ةlJ(.8L|vOu/Fq<7ګݱXab9e_ b6hp,dLycj^.}|}AϷpՏ:\&3LdzKϳO?Ggc1D0hUtKO$j1q\2ch `vq|ԞEDjqs[L[STjc@f*G &<~\D(@b٧ʟg`~:b٧ʷ .88|vO㨑&2wRBuiF^dzO?GL.0d=i󏎯eF|NE*\@z1V(m5Mi Ɍ{j\퍽u ۰ngiWV薠\O?Gt'Զ SwyA5(㈔@GU?FRI$XpL,h2@jbԦp<݊qr1cT~~.`&.6>l~}RHIcb:O%XUT)O.^juд% *-o')3'}/>>U^~ּ'=Av鹺DHy I466T x]{eE>֋s좹ŏ WĖvvl͞ v0! 3wl]=1x~њZ_(e*FӆPjj͇쏤:')^H#OTg]4w*m~vH H2<5ÐT zLWOI*[! 8ݕ$yG9_*e듡^f_5j(%\UmݶlLgRNR&v-^g (QEh0Q@o2Hxcb9F>E1yq_UJ [\- iFo6dT67ow1aW*ɮJ=ĕ3J˫T /O+۔<>t]'R>. T ֚Dp7XB #J^]uOKf@ Y˙T'*ST{x82S|a+vEF(WӺ%ZY[v߾=iYSsj9r)gJ[Fh& D.Xm*=r$ӬeA# kxA=9Y$x£EJ1ן*.uH lFv,$ht*:$[jԮemuK$*ݻ`3U׺ŵBG 22I7VW-+qG$fcIY!9rY=}zZe'O Xn0ËiUqy_YjN;wg2<\]uF.E[8k9ǢѫV$aI,7;_oO||j3-׌gy-QfҢ S2<zHٜzq>dy?%xoؔutU 5ZӔ_=Q Ă݄pz✋#*tCTmV2<O-ϲ>PnL9:qJUiqHQ-lG8C'O(w0U5\;37}^ɏd?lHt7J֨:m|G=Sc<;yE"%efӮVk#̞)z)o+?iiRU:[0.?"n>!>lNtϵRA&}u+eڀ(pǶH&c? '!ND$QƑNbJZDAI~ &c>N:qǞ|,zk.ch?( @䟂<DZݎA<@3k`'͏}S2<oВ~k߻J Қ_3?N|'~ >?rkJ /=q5=Mͱ9@?~{s좹>scW7^r[><_|T3wlm8fhxvvm>6fߵfzKϫ˻b}#`V=}>0N<#Š(P ((h0Q@L rjDTvi(JUjִ}` =G3P[%ca ߱#xύ%3Yaspz)EHƥ:,FֻMEry#|ԙtm:hlH8 # |*u\Jd,|UF&OWV޺հ)Qx)vw,r ece9c;330rNje*_^ՖՏ5Xk-\|}>$BaҨ)R袀nXUPz:}*(+PB{E"4ػIiI.D(Ic(1J$_=T {T(H ]_>Hao.<732sJ:׎ЧLRA1^@Qv ^QE637IE Lݸ9QE e˫gQE'jޱ.m,)X7 親>v?+RN|Ճ JF:,|O-aʹCbI妲Nw/6C`vS, n㇇o,r3191=XDf=Rg6{>Kcivk%q\ROVm%vݑկ.]2-У@yt^S76]뻁2>stream Adobed     '$''''$25552;;;;;;;;;;   %%#(((((#,0000,7;;;7;;;;;;;;;;   %%#(((((#,0000,7;;;7;;;;;;;;;;   %%#(((((#,0000,7;;;7;;;;;;;;;;7_p""  ^C !"#$%&'()*123456789:ABCDEFGHIJQRSTUVWXYZabcdefghijqrstuvwxyzo!1AQaq"2BTRs#$3Db%5Cc &'()*46789:EFGHIJSUVWXYZdefghijrtuvwxyz?"Coon̑`w?UO5}b"O_BGpo?>Gpo?} /Sw#WТ"K}HGXчU : "O_Bj0}'9aP/wOZWUPqLR0WSp鶦Yh%E^ȿ1T|f4+Rx/-cCtin,WWS %| ʟ#7T*1 i5_,8&PF rݥm|W*|W*8Rkn{WC]ƪ0Vɵ@T|W*|WQ|FJ;ii3;,hC[(UCn e;}_G ʳRԧ6BsV &ESm@7sL +~GpoTU4jUg8@{ U-ϪaK MyV;GT.q@Z#7T*ESM{G~"v2WTvy5˂ۚj{NGpo?>Gpo?} ,WߜarGpoTVY b*W Uĸ +1ZZً 0k +GpoT?U`SWøe`{Fyx-WE@ق">GpoTU<9v&+=0Rqi}CQ[t*ά EPw0S=fZnZP }*'o:FpV>GGpo?}>#a E#7ʟ#7ʾ|W*|WQ\ҨAX_-קEbO8;.$E;}_G qGOG1M6kt|&J.v"WQ;}_G1U+PSLSkmPb1+cN.',e7e2>E^ȿ1UW* WWS %J"?>GpoUwQl>SZݮ"FaF"&w+~P#7T*|W*G{ԪQ٪ KƝPaT}"iu3uGpoTU߇b*PQuzRewRj2l/"wO?n`._UŅŦ&si?og̪rFQ@[4xi*Zoɲ |ĂcVN˯S综/?T?U+jt{L8Z|ĸIE;}\~;}\~x*G !$XOTXffX?T?U4Pa*Bsvb`mkӚxvTjל>Eo qG qGwa)öWS.p/M֕O(7e0AiyAq7"|W*|W*ʧBvեO% ,I=!͞QaT EW qG qGe՘%RsFm P0ZmEk_OWSZxP!q>GpoTV霹QPϢ'Al2l%J646xidEg ʟ#7ʂ|#pد;U՜HBLM  s"}hWw#SwR|)䧖Xj DÊIm*\/Ϫ"OW(pc08KtYO9wV4r~E;}\~ʾEVQ?8U8񥌧sipojyE_w#Sw]<1UK/f5]&0nWQ;}_G\E*QuA4˦ke cOjThkI4OR9ʽ TjS prK'zL= E*Tj+Es@Q;}\~;}\~6GAFl8sxh|Vl£R%lP;?#7T*)0 ^%aPI"Z %tq|]v!扪֜Ҷ8q'؀2U :Ъ"j|x6nyU'hcfP[H!;pncDcLl"cL8>`ԦW4~4EhļAO8OR"9g_aY6ˀ1r6^?\O:jf7bktp 埦/:1x /DA0s72V'TTfN^{bO~"Fp348e278汯VV'5'8ɘ$e翦/:1x /Iev[ēxpL{zq/jϴ&9/1x'}U~w:ALyu h ^Mb_MOʮ &jqBY @}}> Tv!i'*O!r^ubO~"If]'1PO%/:1x /F¨Uii=;FdKuK]Uο2Wg?_5JnXJү՚ƇTX#='<" L^3u b@^ vp44Ȩ3]Yn KRCVWRG> =1x'z'PĴqpu7M 0CH9 U sy+ʿL^3u xw|C8ygooqU 7~~g2`vaCKLhZT8&9ZEw4~~gQ^i^jry2g/T*p^q?_/:E8 GܭHnVU`N7ujj,CI_ bO~"j>OSsTP5yuAP 2 n/Q{ϥR@f2ayu<ߊq.):!Y PV-F鶓r8uQym8gah}7̓51x /wͪ굈iR5[OFaUzw*œG73OC_ bO~"M{X p ZuU C*c] οL^3u b@^GS~*c5^^IVF\{&ty^ibO~" 7a ԩ2V4SRZ$t9 /1x'z=.BQX$\u$絛` nLO&/<1x+pߢ^7Pi (qpU/%~ϳFfɓ3u1x /TE/:1x /S{Ztp  .-ey?L^3uy8¦ZʄԤٹa[x~0VJfݥdzA翦/:1x /0{ ݽo8_>d8ɨɂlqm74XU_/:1x /YkC0Z  f%pNA9d V@V&Oo,pϳ{^NVAuƼ%R:5$P-J:Z=3)?_/:EUx.)PcQm! u':9Hw\/KuL^3u b@^JahϮjUjIy?L^3u צcZFjn-tXgcUhaiKt%_bO~"p>jTyA6[xVׇg?_0!~ylpNSU_LQQS&~g~g@^WSZ)s 8A_84>I--Z1x /Mv鲑-3#ң(ү:js3k~~g'J*=c嬨MJm4 <_Ss̭qi0. l?_/:EgVm\[)SY4s\ˈ~g?_ Uڏi.k阭,w,=JCCjq{1x'}'Ԫbݞp50^Gba}GUqCԡqX|r}c ӧL3y?L^3u+:?}7kK贝H,p0U{Rh{K ܆ _~~gݳ8 DLE?gN\2N_bO~"a°n@'w`86&nL3u矦/:1x /[V5n !@t!BqkpnKJ~({k [̠Ѫ"`~Fԭ5g@b<zg3Ue" vkqu`uuUi楣[-DE48F/S2c{JN)2nG=Vⱂ_ mVē /J5ej3!|f2KITEߴlcbUC"$34 {8=Ga)Q&,c{JF'e"'LTaˬ=;e=)ѓ8,Zѕ4X;u5䢥VIiހgox^?w_?b2U h\?Ddu^cw_E򨈀8=oɫpzoP"""""""""""""""/%Z}q./ EȈ}\?}Ġ,/1ίkp_:gO`}?^?4xkpzoW/&@DD@DD@DD@DD@_W}թ)\*?!޺>AZ•K)*ھ1}?7_{W "" "" "" "" ".N &/_wi?E)rU^H{f?¹Ҫ"8J&]K-A 6Ũ i Vu?Mg$0$u+c7b\@VI04n뿎\^ØL i|1pmfŀqhVJU+_apP[6_pE @eSᾓ_ Yn QUjRHs\@_wQؚT}`G櫡0uJn'("OjUgƹJ|5n Xj[*6rK^ lMFKI:Cpn!x|N$<+`C]@_!w_ < q$Cd .}RѴX֗>+G3PWccඣOZ~ *Ѥej^2H&9-bN2d]GhT,U~6r֊lO,OΟ88p N |-p4+ahK+2GuJ`I[p e 8\ELV.z?Lek9 -:\vE&(9[rA/S_ӡUغFF(g._jpM 5 SqX5ZuKd#bU/aTU{Ůsj=HWM zU_Msf r[>gv'G}6ƈ~ KxqZjQcsō"l~? Sk4֩kDՠ߾V4*2cZ;~pu"4-=\ 8uW/PWvB/g-txjlý&LX/?DDEXRk浣Rbpc\VΥ2r{VNU_O|iv$ubaC17[:kX@Zu< ѩMك괻-2ߝ@6 SvUqtYMes4db08`(ө]hvFAnb@3X2f6*Ґ 5 M7CI wE˧g>^<*:&Ź¯o7MZbf$,1^8~7 f!1xg g =峻?y+7ͅy51/"$40ߵ*x"LObI;{>&@"y@^t U8Zhiek`*45^a`f WU?95iNOif/Z&kozS)Va^yrE󣂽p؊Х$?1- ٩ZeLp5p-%n<_貎& mZa$`8RwTN)DPD .xsEZ4M#PKh0OTL2seU1ŝY[x{=yith7.GHqЃG"\'[ S# i}8W}@j>dD憟VCpJ8p(V~}5)Leu0Lckmŗc3Dk/kp_:?=|".TaqZ^Z\';\-pÜCKkECNt2},KAԻ I6:D_Y@\]j:,<+\ @ xµNuTuZm3$sY ^f4Qp\zm}Fix]\LV1JrM 7/*Qڦ"e0NjyĂ%d'=F<[k8:}C>Wa)a߉,"Zt)b\@s&\ -y:Jmn6>8k 5eMg;ZKj НX'֬*fZAMp{ @\v,MLsȑR} 9+F(7^`1_R#㈮ʕ*4HI! cx ()SFzu~u& (⯽SSp| 5E#^>0 /5TM8UA#[|kp鉪pT9Ŏ٤ УV>'Gk3}l,?J@XR"ay+OgKRJXM:|iz.ZK4 e=W08ΩIJH-!IEQX1 fzYMwpO1QWJLE:5oܦpb"=⪲>s򷸏 vskSSHN`8jӘe 5pn}2EZلNXx0O e'uGUљ -*NQ}785nx&25x#hԣ8']-y=Anip Ψ2Xmmp~/ 8<ҦȽg}GH<El]4醖vrׇe i>pUqe DWYHbCXkG|~25fPeKnJx$c2>B"skE &ې$pOJ14piȕVP11ekL\vq8ꭨ:ӒFf/̠/8zz.Sֹ3r__"rWuN+ꢉhxis2 pڸj_)*a^ꔝ ͐Ӫ"8AZ•K)*ھ1}?7_{W "" "" "" "" ".N &/_wi?E)rU^H{f?¹Ԫ"ɞW8h!Ǹ@m]gSѩHNҫȁ]?rj^EphT]kh7ۀ=KT^1^Wgihdۚ.ާ{^ElsO QafI=r;Ogbv>؀>>oSb"ōvf'Q-8^;kԣQ6=`/Xmj/8ʾ/8\>JM^'["~8w]|C?ا˾? P#["~8w]|C?ا˾? P#["~8w]|C?ا˾? P#["~8w]|C?ا˾? P#["Z\?<4*v"C36Z}e?)8Moܦo͐""7["~8w]|C?ا˾? P#["~8w]|C?ا˾? P#["~8w]|C?ا˾? P#["~8w]|C?ا˾? P#["~8w]|C?ا˾? P#[".ñ_BjKXXCO+_ST8@c4@!Dn["~8w]|C?ا˾? P#["~8w]|C?ا˾? P#["~8w]|C?ا˾? P#["~8w]|C?ا˾? P#["y)q8\5V1nSpe:U|Zuq-b1ԇ7`.+8^{7iد3m4!o#egҦ+[0qqm /@n7 62`b~ؼj(1~m7S}<cg4~}Pqb^ɒ 2)HXB ,w]o{>s{. /DDDDDDDDDDDD_wGmM_ܚ}q./ x'qV/DDDDDDDDDDDD]#߿J.%gyu}3\{DDDDDDDDDDDDD[8pD?yǯ_ܚ}/5|"""""""""""""" ?OJyQ]q jw_@\TD@DD@DD@DD@DD@DD@_gOM~W)*ھ1w_1|".N & /DDDDDDDDDDDD_uMǿc+¯G1֪"rUH/}KaZK`"[=v_ i(^qo71{'1gWu8}N̽hbܳpL0)J5E|E_ ++_S\D`R`*0R;J`j-oK/n7 ZsO;Lv7|?ɬN!Bh4Z@}WAy?Xݙ5jS*6sCnj{ it X@^: @39~sG?./|8|Mrc+:;f|o~ʢ.4q}LN)J`a~gNEEԣV>`*SkT{9tp>KST隷/}'֧UwaM55?1\'ҨoMH.ÊNA0N} B""JOP >0V42|D0 q4٩Y\ cXf|?[mrjs lpI2R}J.[~kh?N-$ig5y" ""O6ꖗ: J"" @Y\KE1_У䛱8ʅ~ ?L@_.p,%z؜8Ɩ֤HQsML3tSOP}z8M#sXFP]^Mv4vXĹ(5e5>l;G)== F,MWy | \_'YͧL=7;0tG.5]tLэY| "Ɍ56:E.Xv֣n `iic C5hS@.e"x<%Un%ك*-,yC }p]q}-&Zk)WŲhkA0Z^ӈ X-yu.C"?}īh`unB~qx]~ °X-«1v*\ܽ 7?=|/,gHR{Y ĶvH,$zF0#SYsKن-2 h'"c8N NV(dNm㢻4*a~|rqR} uа_)QsU7o.&VtOZ5H\*|P΢&845kqE{pI4׫y1|[kTե!v@] ?OJyQ]q~Lp(QK9;K_߅.?7_{W/?xjDD_A}M{ I.h6|. Xn$*2+ ve,lz\.wOZ\1a$i%|.'2Uf)3/mC)ifm=#c۩ba):͵@_<[P᫷KKDnH:Bp gV_ 593s ``L /_yi?ԸFVcZq4yCvSE]6cL@_^*U)5ϪApkF5@ZOm8k6 |-ڼNQVnɯ"_SMuvͨ48e"Z-N pP{*  ܙ/Egɧ3k T'\ :Mķ-V7mPk)r|x\!M+Z辏 |NcN#C rת"K֌MYsfWoq&1j5E_05}/n5L$VEĶ#14s6)DZ2fdH|ž+wj}503h`1Lxk X$e k(SsY+F*r~qtՠ#)Qk iЁU&|]u^Ϝ˿s}0ʎڡK* iB.UX0hcEȀNB0U[Z,zpُhw}XN&Jo!h5`f@&kw m*]T-#L$@_qGomlC>z)mFܬw;S x=+iK$XA_<iWƚ# RYQ.5FBcuZyߚ"HY pzoP""".{k1uڝfږXdhc05ytk1 !G)-|Cn8Ѡmˋ p D W""?CR+\᠀sm$Z >)p- dN{l9\;5b`O)h]guIjbN թÝ Mz"",Z8n!]-LPRqkH1 B*OqRv("Ӫ<ĸ+P.Eޑ{j_۠0 j /xk`yſy, S<̨Kn!M[:H8vaˉ{J09gW_p8RŸ9 M־W" \Swa5UZ`^bQC4vmWc8V8:6S,.*#&h;_GE3\{^Yq Po}'aTsFܕqxhYv,#1PpXfv*k:(>k=b1Z,= I}2ךDysaY8ȀѳrK}qxگʌַN-{FSp:{\<5W:ydBI3~un.Z*5)bqK/[8EyS4yS4Eu0u)Uc1lזYm F' !K*Ma--k {""NpgZ53zEЫwNvw4L @:/DEܡ(Oъ52Gxk[VmJ -ŤIg?E[ ?K=I¤:>,|F }5|""`<;pzmuƸo'Beux4ZP=ꅎD@]X;u)Ť{:^KqorvdYf8_l.SlVe3ٗ͛Kj_aٌuJn{6[f_icc0vʹ.?3m:깼^n c,Nu.qԍ""&qTq<{vF{|ڶrc<.; KWi˭ !B@___v*q& n21ڈb޵e o tyKwj}}!oupO1|".N & /:,bqfRCuJL1 }H_8ұxM~, 5y'4rf(ԡRcXrSsŢ"ڟWR5`u7kaq0Ux16!7޸(6-»6a3^70*43H:FQ}_\&/WRp5 cWge|eB/;_uMǿc+Ъ":<5G7Ϊ q0q*m5p}y1tk7 [DmNYIۑW9ƒf}LfaY>fgżCE2iLu_^!Fg!kf5c൏؊]c9ٔ66s@_eP{zqS1|i[uFԟ[a|?&8~>SO Qaf}]^/_L IέL +q] qOX3v0`z+SӡOQHln8LadĚdMK|UbV!u?c0TFb| rvˬN.7ܽWP~ RcZ yw]o|" "" "" "" "?[mrjEtEx'qV_s?Kµ|2" "" "" "" "_`>Ww/~q(?,g輳/1Π"" "" "" "" "7x-en0@_O!>O_a!?ƾ=}5|"?WmrjDDDDDDDDDDDDDE~AZ•K}թ)\*?!ހʟ⛀⯽SSpU|b"""""""""""""/bE~]6cL@_⛏lW/_uMǿc+Ѫ"pirj%|oO>+$w B>!P=BcDE}NʧܕOj⩽oz^RP⬨TkM?;.eSJvU>&q%FL `(pi.$E}Nʧܕ =9D9=O@ROi-:Xy?q^l>Zn ֨\v/4n+øj|Khl4|>9 ߂$+~ ۽A>Zq߭$+~ |P*wni~P@T|P)O}BZq߭۽AQO}B>9 ߂i~POwnEG>9 ߂—#31'Re/|[w/5--9s /'>[SoW[w'N;z"oO|s_ӎmޠ-8|s>IϨVN;z|[w *>IϨV'>[U-8 ӎmޠ'>[SoW[w'N;z"o_]x'mzAe2Ip|[w/~Pq,G|KS^P7OZ"ߒ|s>IϨVN;z|[w *>IϨV'>[U-8 ӎmޠ'>[SoW[w'N;z"oO|s_ӎmޠ-8|sv|s` |ZtV\6e7+ӎmޠMyS_sTiPUy;ű_ZJopApIϨV>SQŰ[B%̤ @\_wnEG>9 ߂$+~ ۽A>Zq߭$+~ |P*wni~P@T|P)O}BZq߭۽AQO}B>9 ߂i~POwnEG>9 ߂-Ʃh=N]p-8 'n"qk4@]-]ZL&W|P+IϨVN;z|[w *>IϨV'>[U-8 ӎmޠ'>[SoW[w'N;z"\$j^aK/0r_O}B௴5#T,K۽AQO}B>9 ߂i~POwnEG>9 ߂$+~ ۽A>Zq߭$+~ |P*wni~P@T|P)O}BZq߭۽Aw<S(V*Ҥ־^-(|-GUbZ]?$+Gӧ]k`X`$+~ |P*wni~P@T|P)O}BZq߭۽AQO}B>9 ߂i~POwnEG>9 ߂$+~ ۽A>Zq߭$+~ |P*wni~P@T|P)O}BZq߭۽C /q 5FIi$@+~IϨV.)|"AmLE*D|[w *>IϨV'>[U-8 ӎmޠ'>[SoW[w'N;z"oO|s_ӎmޠ-8|s>IϨVN;z|[w *>IϨVXpN#a*-@9] /i~P|KaSM>E$+~ |P*wni~P@T|P)O}BZq߭۽AQO}B>9 ߂i~POwnEG>9 ߂$+~ ۽A>Zq߭$+~ 'V;pn61xwυv\&f[w/\kŸ?8ƯgvYKJҪ"ช|475J3ĭv9aRe! -u:Y0"VǑ88Nj{iWRx,@i^ ULbk5ƾv7薆x&/kMfs9,8:k[]s [ʁf~bg&2Ԁ]Ja2VpkK|"@ i cpplbZP̸G]\_שS}Bc(uqL {1Rf enhk;lV`gu܎fC=EϜ˿s}(p++1y%]u@_*ܚ}5|"" "" "" "" "" " \_Oo@_ G]#߿J"?=|/,gp Yl?? O_a!>O@DD@DD@DD@DD@_wGmM_ܚ}__Vs.z_aj W;ʏm/.*" "" "" "" "" "" /?xj~T}_hУ?Zd > CIrAafqphZFQcIs\ 3wtR/0a hpi0 x}'UKs2/b2gn(0jT֮[e4ã-ZOӭDPmWЧQ ח ;a»XܥpLCxU*M4v@mBܳ,'mel]@=;r$7&5|*Λ Wp`8~+SqJh0mc=.գ\u'Uc+}2dzl<7q # 4 ԙ\:'Ӧk8~zs[gFq;\xTul8fe-?bjUG3?>&&pIvT ުge,NkF.̶o޷6j/t@U5S|z!n\3X Pt+ѯ+PoN(݅\8<7`X1/ĺ+&*jӬfs`jphzq1c8p ]h~ϦE0טoe |5: \O9 oU)RR[RXCd8q..~%xc):RLVk[ٔ/1ίkp_:@@  Īap0IͨKɨ#]"p:tp}:e0Eg8.a;Kq,awfiہ|-_RB۴e r^mpeJI."s<86iZu@CpAޒિ (bk8WK]p3X9F5k⠳{ZL7P$XeN!OVS:i {P\EZxjE/} 3dͧjWV\{B,bG2U &;![ڹx//*09*I8-1ހeq_Fkr~ڌrN0V },MafP92=KhC8?B<١y٘ټX()t(uw@sw@Oi5?D?yǠ. q1 -s[sA-ʟ {[04W^ (өC n{*Hsb #uGRSÙauGꎤ=`]-n-Ʃbtͫ[XA5,I@YV^ :iSkROZ \p1VZi3J٧0ίX?CAs#]Kp׺ lʮɹ!nfaf&!8l 8\/?_|2|d%C @V;U8⺜KPel5s]xs#` X_xtw.7j({9ksg:4莳JT0{ki1Dr7XW԰cM|fg26|WD#(ԯ^`J $Rx T7\ޓ]B"Өqg;0PS ij^L.*bk]e$pX\{-Z*᩹̆liyU{ԩsIe&ͪȀʒDq(p%z5@;i5,mCLGiSܲ& 3UU\#";^!`nssL :oW C N&ZɥvB"y1i`8j:+R@O A9c5^T\Ci}gNM+T^Cj:[`CI6_'Gu?shpͩWiU\(33]"'8 cbAMK;Vai6kK f$ȂvNpugh*ֶ{MD؀CCjTFytnAsHҵ:41}"hcΛ:cqqp VO0U EBi1kP8t+l,C@2>vn y:`&N"q{4m2V'ԣZ*bDCpchS͙q.SpU8*p4gBo6@XPTsAM&9?fPSj[H_.6>/Z.Ż_Mi??ϭ&B3Å'Ԣ5̬H1r%b"EpLpPҥMxnb9 gŧqLahIe0.ѩtJPVe,0m$lXG">MЩV]aR/yй聹OVzes[PXcw?0u^](k14FG4%k`F!¥v6F id@Ib"|> ي*4:4F8w,q/ Jk\6,L]Kصߏch350ڮ{I;w]ob“*14tZ7(Oq.QGsJ+$A p?IKK 6\Xo=eSReR*>]༢ĆkցdԪ"{[y4 ECA}Wwp :%{\+ ]&VX8>Wxc*̆_ESi1T\ZwX@\F,o;Q^ʭqZLpKU*9K};55, ăݢW+4-ԎhwU;,؊'P:y=sӧؾ&jQbCDpp(8c^<IC[0 ,w]o{>s{. /DDDDDDDDDDDD_wGmM_ܚ}q./ x'qV/DDDDDDDDDDDD]#߿J.%gyu}3\{DDDDDDDDDDDDD[8pD?yǯ_ܚ}5|"""""""""""""" ?OJyQ]q jw_@\TD@DD@DD@DD@DD@DD@_gOM~W)*ھ1ywp_1|.N & /DDDDDDDDDDDD_uMǿc+¯G1ժ"y)|4C?ܺ: ¾eICs. R8pk?rjݣ'8 N6ҪG#ZbPy)}Jk˘Kq6X+Gh>E,As hTMۚƧܨG֝5>;rZv@Y6Á-/4ɞ+xjl3Spl8W1.ou-ˍq,J.*`6ʅxE~oO|wn&U}ߕ>Q?-ߑ|wn&T~oZ_(]S#+*"~oO|wn&U}ߕ>Q?-ߑ|wn&T~oZ_(]S#+*"~o_[Kq&'Wh;])Ȝ//G> ʾΗǟ#& ^QW9ϗ0ma|Ⱦ;7~*|Sw7/|c}ߕnSw7Ⱦ;7~*G> ʟ(]PȾ;7~*|Sw7/|c}ߕnSw7Ⱦ;7~*G> ʟ(]PȾ;7~*|Sw7/|c}ߕnSw7~O,?KS׭T2D |?>1GW~U<#c11ujuP4ClEߩS_ i|_wO|cw_ >EߩV>1GW~TG> ʀ~EߩS_ i|_wO|cw_ >EߩV>1GW~TG> ʀ~EߩWcɯ%e*ue%O"k#+*-8'VVMauG @[S/[^Ϥ 긿"Mgx^1GZ6CQ@ |_w@["M/M߄ʴQ?>1GW~TE/M߄ʟ"MK#+*|_w@["M/M߄ʴQ?>1GW~TE/M߄ʟ"MK#+*|_w@["M'n"݄pkj-8|_w[/(x4urV5] jO'8ϯú#M8J|wn&Uq},>*bF1GW~TE/M߄ʟ"MK#+*|_w@["M/M߄ʴQ?>1GW~TE/M߄ʟ"MK#+*|_w@_uOq&'Sp)Ȝ_"Mq\y>(jss f|_w@["M/M߄ʴQ?>1GW~TE/M߄ʟ"MK#+*|_w@["M/M߄ʴQ?>1GW~TE/M߄ʟ"MK#+*|_w@_[䇓\Wz8N5)G ө]k+gKVk叨\ V\wa:,efSf!mG:([_ >EߩV>1GW~TG> ʀ~EߩS_ i|_wO|cw_ >EߩV>1GW~TG> ʀ~EߩS_ i|_wO|cw_ >EߩV>1GW~TG> ʀ~EߩS_ i|_wO|c8SE 8w:AQD"o|Ⱦ;7~*GZUYRk. .;G> ʀ~EߩS_ i|_wO|cw_ >EߩV>1GW~TG> ʀ~EߩS_ i|_wO|cw_ >EߩV>1GW~TG> ʀ~EߩW[8aP=Cms|/>1GW~U~Yq\~ CVs<s/~oO|wn&U}ߕ>Q?-ߑ|wn&T~oZ_(]S#+*"~oO|wn&U}ߕ>Q?-ߑ|wn&T~oZ_(]S#+*"~o_O6;n61M. Ai_w__c78+a^-:J֪"&_T%z;V64Ui?0WpZel1&oe<'S(Wm0FQG1˓BIՙU4 l?Xn&ʥkI|irsE¡`ַ%AVe88@OqUv c59Ēg@_X9^Tn!0NX?Lñ-ѡ"yJ;*p0;AVh|ǂݧ1lɇĵpf}38H= &L .7ܽ9x~ʢ"""""""""""/&_wGmM@_8je<ĸ+P"""""""""""".%pkp_:?=|"""""""""""""-w?[8Exk~O@DD@DD@DD@DD@_wGmM_ܚ}__Vs.z_aj W;ʏm/.*" "" "" "" "" "" /?xj~T}_lФv /%m֪Y"`Oy@]|kUc*˪9m--o,b^L܎K58~fqK~g~ pɄ8\E}(n&Nsd85** X7X;|@V,^*\uՎ,x!CRfrR"q.K6j;`Xjioii՞ )osIe,VNšg{阸`Y}i懆漷˿s}x/u8n:%[S-,?H˿s}Qs zO*UHSش^yP {0WÌ}1/-?68 egyR38Oâ"$_W%sGHP%7J. qmf̸^|/<FLEF@mK#Yc'cjTČ3 1A@_2ܚ).E][u\ &#x]W#qtf{> [<ͺ"D@DE6$ԭ{نH]f6rQuTpelVx6k$ [ :FT ik\~5h}fpo8yMˋa 0 ^o%I!jaie0$؀eb F EbϫL 1bI *p N7^\L[h(OoZ|-Kqu0)ӦX< MC|m|C~pgJnp@X")p8|7iQ(2j4ry0Q-lӮh@\_YSz0y5%lkK8/TCX yhX/E?.;x蜡AjaùE]#߿J #~GWR:@ yu}3\{DDR\@}&7a\hU^7k9p@۪Ḽ\jƹQ'Y(S |:(Z_) v+`ժq- s@_.p[T YFQَѮ;fk,75&GSh@.<"en0]/_ VTc nkpaj}j8-ڍ۽]!?ƾ=}^?4DE?+cR vgnkxn ڕ<݇ZM6@\_B8OͩU>mƫ Þ'TVQQ*6i3zvͲ"t_S_X^MAUCmma0Ԩ &'n!ƟD4@N /EǂpF7>)԰*Wo-,p<_\*m&V쩚M.^ܚz J>on*g g8/>@DWah;ZQv8 Т *79PVh8FpQ}&/gVQk]Uh4!UWa0>fUW `'tEE|.~իyaÞa;kV.h/c5;8_7"4_P Í֭篦۔v]$-&SWspI_GS@] ?OJyQ]q^O. ZSjGѠ;/KwW‡e|Fa@1DYa¸^ *U*S*vLZ vV71ZA7F;`|>XUVXjuw)᰸ZϮR@ڍ"u0\Daq5kWm,~3|/ a$b[iA|/e.!V-N8s15 \4 f'DEȾ KϫWmCGbFb X#EOpT;j0]i@_:⛏lW.}'pR^Ç :v`܃\-<*4_MoDCpЪ"$Ly<~]!`1وJ Mkc'uNpOɧ81T!F]uLA/ej-etE8ߒ76kx4}7۬--4"wb Q<ۛ6mh|xWTSzCX.s$u*>Ri+4EB*OfZ 9.9@=[EFcZ*0Ml홰ꫭ,*5i>*P{@[h@_RƵFE>s{./`gox^?w_ExlEL%VVdfhp+8JT*3*b ""JfYo+{> U5)zo,jf߹|j .~,q flUshcE԰^vT]P<5b8n&#OOs+vy"=f88ĺ:eK^]q61P*Ա5(i@h~cr%}c7T8tr6ϗpzoP"""WPڌ  `*ի&>vnM۶@]|wb7=mVItt)lF$bU8\@i-*7C&оak8NgjƱm؞fz4p(`ھdk&}=)0](0xj4hE04Z/^Q繵\ Gr6_6x&#SK\6InqC1@[^x8j"eСqzܽv74?:'ڹŸez}*U+˜ 3LGxcpىef@yHDEoqxJTKFh )0m7UxJM!m:Ƥo|/DE<&fVv3_D1TN.1g[l2Ϋ*I4?i"=ـay.Rcvfs#Xj?}Ġ,/1ίkp_:wıj0 Xrq< /VSY|DGתʗlisCKscd@_^|I t|XFUxſv 9JT@_^=jc^544TpoYN>UBڽG9403qAU&\K12\r F:1~PRdz8 MG .i[n0@_O!?ƾ=}^?4ECmJ8u*Qqk(vge1ӋSGg٤f| / {)`<ꋪļ%=R唩8v'?Ȁ?j6O>O@S i 9pڐ`c .#`ً; Npg &dYmp(0 ;oۧ3)1.gKz ;n*uN \|^ t K41]U4)Wes\旚H(_6>Q`)}L[ «kyy+1 [?m=~g;B_ Ÿ1Ԗa;L,Z;YآeZ^݉.* /}<=:UT6ñ-5Yq4i+OөM"F <.\4{BEG 3?qnvUb|M5hLI$swB/*6&a]-=AMKebƭ|D8f!>k5'./WsB90#x^Qw_E򨈀8=oɫpzoP"""""""""""""""/%Z}q./ EȈ}\?}Ġ,/1ίkp_:gO`}?^T?ƾ=}^?4DDDDDDDDDDDDEt8=_ɫ_aj W;ʏm/_Vs.z""""""""""""""""""?*n_gOM~W˿ӂlywp_1|" "" "" "" "$n=\}ג?7ُ@Ҫ"~ #5woS2Oժ5ezN [;]]ƺ/m4ZZ2rz|Ԩ{vq-u8qдM±R_8 ra69Z7z|bY4٘ۧWc^r<ާ!O7zRyZI}hxp0,FμGN)WSplUkM+XNf7^I+KWk*`"S ʟ 8f~U7~T_/?T39:|? ߕ<?n@q?Ng_;OwO?O~*"/suO3?*|ӪW/SSʀS ʾ@q?|?nOw@_ENg]o'|;15RR\EV+?n3S`sMkG('[qLN&6U I֝9+NgXyaRx`p<?n@q?Ng_;OwO?O~*"/suO3?*|ӪW/SSʀS ʟ 8f~U7~T_/?T39:|? ߕ<?n@q?/n"GRXLVfy/SVv+ j%8R4uFߐsuO3?*^{i{eNq~K?n@q?Ng_;OwO?O~*"/suO3?*|ӪW/SSʀS ʟ 8f~U7~T_/?T39:|? ߕ<?n)3ěNX9v+8ohܹd})ӪWR"*Nf9sw_Ow@_ENgOsuO3?*?O~*y/SP|ӪSS ʾwʞ7~TE_ 8f~T?T3_? ߕ}9:>@q?|?nOw@^䟒\WqZ8M66-V/c/F3Nw9`0O"lW0}WjY$|qmg {9:>@q?|?nOw@_ENgOsuO3?*?O~*y/SP|ӪSS ʾwʞ7~TE_ 8f~T?T3_? ߕ}9:>@q?|?nOw@_ENgOsuO3?*?O~*?O~*";pZOm@j4\DA&lkS ʷ|קUΣRHqݺ_/?T39:|? ߕ<?n@q?Ng_;OwO?O~*"/suO3?*|ӪW/SSʀS ʟ 8f~U7~T_/?T3ɞ%(pxv1aTQCt}y(7~U[+Rbʏiv"lP+S ʟ 8f~U7~T_/?T39:|? ߕ<?n@q?Ng_;OwO?O~*"/suO3?*|ӪW/SSʀS ʾ whbgegE^7~UJ׫[qQ|afq?EӪ"l%|Ѩ]&s 9atV=RAD6=+her<֭!PXI{O| 6 "$j;E*@}%1fU03ƜT.gXGӬh*Su8{A'E|/ѕ~DE̩ZN!3+\Kut)4&r06{.NL1ը$z1m`8 ײ(ʀ_{AL .7ܽ9x~ʢ"""""""""""/&_wGmM@_8je<ĸ+P"""""""""""".%pkp_:?=|"""""""""""""-w?[8Exk~OkpzoW/&@DD@DD@DD@DD@_W}թ)\*?!޺>AZ•K)*ھ1}?7_{W "" "" "" "" ".N &/_yi?Eh)rU^H{f?¹Ԫ"ɎxÇfT$6.N1] 0G&_" ֩)תLkg|>.բyFs `85Q}(ͦCZA3=j`wk1 a${ F z>C^ރ-wF:OeQGI"@@\|/ jkF!eܓdYn.SUQXэl17r\j Q̫M\Zs^>or)0bJeVO u72*KH4 ԪTe*\PNN+k;Džج'60>hm6z: AH-0 lF62*xsZC[[KP5k?5ݭ6\R"ݣ:8 L\ðt}T5qAƨ/ɒZp2h\s'1eX EFץ[YpҐѪʷ 6"7$v.#Wd:DKxٍc2;<@ m3zLOs~[5O0dmSe6Dv[[`V591 CAUU8.2 YuB31HOqݥtOh|41c[#ʑDtpT]r5~E`R,tĴ`6 եu05bR7M'@ܲ-}V?(VŜ3]%W-#ӦA\DUNG0NѵLUÊ̬ * GSXCn<78k @ha*1j 2{֦;8ZTNDZĺw&,>#q6f̵.:H#N7\b֑>tWĻ5(ٶW5C '@n|Ca@Z /kHi j@-3-.16첛L8N'өJ\!+L]&# pM1M{OD1iE a1-7L2F+µ T8e:o+ZQuJYhwMN?N4[KgfŌZe_ HQ>Ra M7$rYa8 2? oFRuOryVRN es]cXu FNxi5,}ŀDu%c_ڬZJ(CV*2u Xz `i5~zG Ai 8gX@[bqBZ<0pm<:ubkfQ^3Z?([]PY3#ԍ򍕚N/jmBNk:6 3^Z_YLv%Cb&olT,;?j|U-qsE20plp[U +Lՙݙd1CR:8sEq4]Y~|k z^?4p :ϨP(ѧ&.KxR}GUX8nٹn4@QL&c5V^;@7I-ݘvR{ax=ZWӭS M:9C)菺9Lu^;ucu[Y 9` N`׫O#^T$DkM:5;@aL&O"\;)i(@9Nak>Qҩ\6j/cCaP0 *:LI$zʺÚx.ֱmLER״A ~A S`JW.ֺ4sj\X y\\i4Ria!]ڠ* ,u,;;J pA{ mp~qGҦ3ђ=JX)ۡeJF'ɯP2Z?v?s{6bfLG,w_CIRS3Ec483 W-=Zgĉ.+aj5xzm}B:W 0e|_l^;˷Wz23jkkT,\={ѣ[C ò] ]|.&)apTjT$թٗZC7N`1 hkoj=Z_(Npӊ kjT{1o&E*SR5:*e'ۇUDC^X@oH(pQm:q˅6`ܒ[-:\R:;hm AGض1TIO)Y86 hN%ԇeA/asdE8.F Pi4`bx] 8 x9XSlHDbw[SH1,p0 ޕҧ İS`heZ $4ːgl6UŠi֚u/"dcyQ]qM 7 Z:YS7kTT6 Q]qEDDD]ð0;CI @9A渋8 -4 zNpp ~B:-qcJeaXs]n_WG(xi18DAqkq ukUC%2[WO *FA*<z +O`asUٽ  "Lef{aVng|-`νwNHՔϤf s+aS Xֆe<>F"iZZDAdxEG"1X\j8b&Oz.N &.6#868ju̲Cr{v|m8';M*0.ct3{@ʕM"ڤ8 KĜzu͑HzW0KG TW3RfI-Qg왇 vNC35_+c]O1,.=(uvժ"$.{&;S<4D6t!E乵Fn3s9}nCu.Z-행Cnz.o("j2M?kmfS-`i ܽb)IėdØ N r:,sjKXN;,~PxxWse1OI(=JQk]Gwชxz;WbqUSCHh֢"LM(Z{ 7FEN;ˤ40 gox^?w_ .7܀U}5|"?[mrj"DD@DD@DD@DD@DD@E<ĸ+W/%Zw/~q+GE3\{^Yq Pl?? 7x /_C/|z"""""""""""""_WmrjEt/ڵ?+Gu?G/SRT\CiqQ}?7_{W/?xjDDDDDDDDDDDDD_wi?m8/}ג?7ُ_ ⛏lW ֪"xh>zfnX/%fp/q{W ZVVD0ճø4Whզh z [: tq>I:J(ѥp5if=nT@UxGڬp9E^+i`+9дrW7;Uָ F9 /g WC%9ƒO5ܧPUcj6rPϛ;O6w0DE{p!|'DxZ 8V|^\֪7\5h8EZP-x(z9=ʞs_z?}k~CS?X+|*yTEߥYO׈b5#P~G=e?K^#'kO_G@_mZPŷʜ+ڻ< 켗kO_G򯸣VȚ{n׈bk~CWTK^#Y_5#SkO_G/-x(z~G=e|OO9=ʀ?X)ZP>s_z?<*"o׈bk~CWTK^#!p, ͂I?X)ZP>s_z?<*"o׈bk~CWTK^#Y_5#SkO_G/-x(z~G=e|OO9=ʀ?X+%ԯỊS1 &H-^m5#W{_pAq#h+H $Vej;Źt$kf)}ox#N&ΛWk~CWʺ[1aiq.[lVeG~{>K^#Y_5#SkO_G`6R+}'g}k~CS?X+|*yU8Q߾{2v}W~G=e?K^#'kO_G[lVes_z?<*"y%o]>،eYYRSMWvo=g7us_z?}k~CS?X+|*yTEߥYO׈b5#P~G=e?K^#'kO_G@_mZP-x(z9=ʞs_z?z^D87ZC ZcwS+k+Vsq2^BV;{2Աq#w귌% jߥYO׈b5#P~G=e?K^#'kO_G@_mZP-x(z9=ʞs_z?}k~CS?X+|*yTEߥYO׈b5#P~G=e?K^#'kO_G@^|q  ²&Myq0K#ԸYUyOVx?-{4*2nWyTEߥYO׈b5#P~G=e?K^#'kO_G@_mZP-x(z9=ʞs_z?}k~CS?X+|*yTEߥY_I'X1GӥVEK|*.*f'x$M-x(z~G=e|OO9=ʀ?X)ZP>s_z?<*"o׈bk~CWTK^#Y_5#SkO_G/-x(z&>O~0+TeN 콙'FWyUJT}N s0ROw4ת"L k-~&b$nky?BBŽA \?է Tp&vM@yEHw5Yx>x }&84i\EP5r;JNdT(g v_X$ ]܀*c*sNchWѧe0g#@ ieZh%Y9coŨԦƾJQ;EDDE>s{./`gox^?w_E򨈀8=oɫpzhOo_ 8j"dD@DD@DD@DD@E?}Į_`>V H #<G"kzh;yY\w.q|K0R``?@1Gz[8p v_O!?ƾ=}^?4DDDDDDDDDDDDEt8=_ɫ_aj W;ʏm/_Vs.z""""""""""""""""""?*n_gOM~W˿ӂlw_1|"" "" "" "" "$n=\}ג?7ُ@Ъ"%8{84@l'l(7vb40Dyf>ONRcX<ԥ5'4 e: )OT~1iTPF/Z#!է@K0:mU(֧I2>RM}G1kCb\*Cnp^{B``mJyGs*\Xs%L+iTuXOk]E̊-vr)5)xT>}45t0Nkq*s{. /_A`)v'Aؖ5Sb]#]WϮs*Sf-!knW!XgZpΨ[^êq,nhI4Z\SO4Ue\}+F,q. v`kqΩ( cG̝egGX 3MZBA1\/vb@h>rܦv(:|;h0[[mqF, :OM*eg9ٷ xfVsF'ఴpc!(YRfZeZͮJ" 5E\ךIs2cicn" \L7XZujWլ_󹽘455]3U:<4/DDEZւ$X*4 zC4 4KNu7A#`8WSOϙUVqnpIiR5,ݛUp^û\apǛ>p3KvCM"#5{|g=~ \1Y@]Z#_50e rӧԓ<'8faAϜCFCKXVPʥ&[HF+RrSXVc&roN&0]{bD%ZY&S\%N4Lꥯq5 tO[ʆЮ10P OipDpiצ0k{u]l%:4ÙP76q(R9WaPQ-`9͗cէ_ɞ7R1F$/?VPUNc;0Y1曚ش;"N-jah:L-AN ~Ju^S uX-/0O NJ1~PQ1*toT53\,yAwfzqhɥ@S`8\1_==£b/)S8j UAqq;yWO=:L <>!/h +E50*ӤӇsHIo8@[^ӪK0[\l֎bML,eqBq_!jJ:. ΡU[Gcx ^V7N 4d ῴU~ Mꎊt߄q&3.׽Ԏ$Û.te&7ZaEGXfZMc[a^Z% @]w,>'SE1NNعzDܭ'յ01=wSkHsYX>F2"ҧDZy7Q$6>tE`=;Rj;BS0)#Rr^ #}Zohڮ\kSuP-egOեW Uh8Vހ`?(p>o8l̬ N|g__Qĸ p`qt͒J*?!ހ`xS[S7i<Gj?0uScIV3sٹ5|iږ5y@[41L)y%Yi鲳6G`k 7ژZ;ZEpuxgy[e:uf [U68"͞CF ecP3[u/#pǶQ/ 'WfpoVkx $qɨc%! "|D0_O_)(~BW/'JCEُ22%! "|D0_O_)(~BW/'JCEُ22%! "z~NTo8wa˝ .l1W?[mrj" _`ȟ!+Q SfBW//yyE?!+Q S%! "ǙLǙ@_c?>BW//yyEJ+WZ8c0ՃZBBa S[ıxSk9T ؈\ <{'s$q!ޗc%! "|D0_O_)(~BW/'JCEُ22%! "|D0_O_)(~BW/'JCEُ22%! "|D0_O_)(~BW/( _`Ⱦ?1S1P&*xw Ì^Rx/{aw%! "ʋpnyE?!+Q S%! "ǙLǙ@_c?>BW//yyE?!+Q S%! "ǙLǙ@_c?>BW//yyE!kQ SyQN'C=/7e&Ym,1WtH_1jD0_OO )e3e}JCD _`Ⱦ;1S1PD0_OO )e3e}JCD _`Ⱦ;1S1PD0_O_A¸N v"#;CD4^]+|1Ӫ"$->Obz@Ijq ڗצm6=ep OEF4bCou>Ta"cMAEkK\{$P ɗv 5*<6E)A,kI-,;hZ`yBKq:E'!Tac*8j6r"G<_4\gLg%cxe Ƃo%N[En `sִ+o|NZBgRHpu)cYV=H&|]u^Ϝ˿s}QpzoW/&/DDDDDDDDDDDDDDD_s?Kµ|2 \_ }@Yg^c?Ǹ/_Eyuk-w?"i5?D?i58=_ɫpzoW "" "" "" "" / jw_] ?OJyQ]qEDDDDDDDDDDDDDDDDDE~T}_ʟ⛀⯽}ߗͧ/b"DD@DD@DD@DD@E^H{f?¹|*$n=\Ԫ" .% UBr7;ц`q<7LCĶzlRpeBP D -9@6v"\ңfpX3\ T4?GK[<=<0~vL69"oV1:Uٜ, "GV$t*pϤ" T8KUQhiϔQRNJWj`g.>n/RX½轭43N}tB"\&A4*TC=sZ|ZƖ#tw]o{>s{. /]> q5Ě ڄ #)n x1B!ppm\ދH.< Tuէ`sh$p-zjSSx}6<Ө1ݝ. +q2?JTkC"#h)0Ԫ70u6e\"» KXp4G [8.DU^ ܚ陒2S|0|@4輁wYtw}E_`t3A E֣qaYG᝴tsB0oû ywd\IۚJT)Qk]nbOI& (*Z>nYͽ,E~kk%:PחMELzM2~k83a|/)*45pk?3L2"򾃵u"5w?5|" ,Tpcs`rI. ᳿;KI u7Cjԩh f426@]7`0W @ҧ@I9N/XPn*Z u|&iD}esGoۻI$S"2@6[4s*TqQs֍kPW pQlөX 4iʫYkfs\7AմR6K(qiҮL9ݮ%@[a<>gRmlKk4͗+!9^믇ฆ*k`,1TXACtOP4+oi{\HƟGih ^OSr؈ڀl`ƙN&TVdRS6!ǼJ c5qP@WTc)Ml@lDk>&yv CP6|;7ƺ-5OOegY<&a]w%aO; %Mm0.ŵ$Iwy.N'yZL 3#3i?QcC[s9u0jvqp׏ yخ(:L-* vdO.@p:ʵSm0BJk/k]"M #Ú LC]N.(qnW i3Cِ㘙=BqT𴩹v^\ $|n\*ogJc|Ls"yg^c?Ǹ/_Eyu z5YI熒t taO:Ɯ=7Ve.͸_3e,yLԪң^A{DcZ'}'L.4+ <.z_%/q q9bXƲs P*?!ހaWʯGX Up8l%+aى.Ċ! ٹH0݇cN `oҨCQOkNLaRvJT)AbFj`E:&T5IMƱkVZo96t[:ͥMI5@ E\Cai e6>C;9̍+I0y#=ړ)y![qÝKt;ʊң/P43Et8TN:ml=ԍWZ Nҹ^%NkSu"E$_).F?VRezx2AzcWTXDkO.EGaGنi/{qSbdew_ͧ Q~Ru fib8aFlb"Qu=z*04;FҪ Z Б}],7Ҭ*'܅w9,3":EV@dM9d70#WNZ4 ݅™K9?7-FFZ 4CʞQ|`Q\*.q"6Gᵸp2e6>Y1mWQ8,=:O"fpI,png1nQ 2 [KQ{4y؇f¨ӡ&Sm "#2;Eu8:h~sLNy޾eL HvAժ"#, uPk6AɌ S8pKO #pǎ;wS5ob TC {6P48N )y/Ĺ}ZF-n!R~YiՍo)' ¾0 :œg԰XaEELZ3@[nXGҭIوT$v wwJkժ>W 4 nOg R\T5\旗7M[෸g ©:'9.%2@ž&|]u^Ϝ˿s}QpzoW/&/DDDDDDDDDDDDDDD_s?Kµ|2 \_ }@Yg^c?Ǹ/_Eyuk-w?"|zi58=_ɫpzoW "" "" "" "" / jw_] ?OJyQ]qEDDDDDDDDDDDDDDDDDE~T}_ʟ⛀⯽}ͧb"DD@DD@DD@DD@E^H{f?¹|*$n=\֪"+o(ᢥzvm{  ~ fqԸ/uZu'@HnF#c**_%X۾kjS>].Z}9-\76jF79& j+趝WڭsHvŐL?|1BD+57v8+Qe 2: /Y< سx7 k;Ĭ{@n,O&w5kppIsp_lϜ`˿s};Q|rdrd#G/DE#G'G(~K}G(~I;QD@_w;QJ|'*`Gh;⭐Ή^@ܚ#G'G(~K}G(~I;QD@_w;Q|rdrd#G/DE#G'G(~K}G(~Kx#8*kT؁+ J6漉}q./ EG(~I;QD@_w;Q|rdrd#G/DE#G'G(~K}G(~K.%GQTR[Is8+}@_a%[Q{v\Ͷ#G.73\{E#G'G(~K}G(~I;QD@_w;Q|rdrd#G/DE#G+pHu=jj02H y7x /Oĸ8,%CM~\ |rd?D/i5Gp9C?O#PO""#POw?S%w?S$?|" /?>Gp9C?_p#GhFc@dz?:'|G(~IGmM_w?S$?|" /?>Gp9C?_Gp9C?O#PO""#POw?S%Wɟ'8t┱U188ϒ31Uz4_RN-'c. }թ)\*?!ހw?S$?|" /?>Gp9C?_Gp9C?O#PO""#POw?S%w?S$?|" /?>Gp9C?_ָϓ _j:TYʎ"K}!|rd)*ھ1}G(~I;QD@_w;Q|rdrd#G/DE#G'G(~K}G(~K<8!G2m >V9pC}!.~]6cL@O#POw?S%w?S$?|" /?>Gp9C?_Gp9C?O#PO""#POo|' `aǣ ::)_uMǿc+ת".! UO`5wp~ɠz_8b6M6k{č![j(bjUSs2E7<XvlpHPbbZn# Գ,:z-|7XWf?J]ǒ"w'5N|1._%%kUΘ2:\8PHR i +wq*֢1iTAi kZ4hw )D@Y37/r|]u@_*ܚ}5|"" "" "" "" "" " \_Oo@_ G]#߿J"?=|/,gp Yl?? O_a!?ƾ=}5|"?WmrjDDDDDDDDDDDDDE~AZ•K}թ)\*?!ހʟ⛀⯽SSpU|b"""""""""""""/bE~]6cL@_⛏lW/_uMǿc+Ъ" .#M ӐDj?p5I W0@-W P;WFnνSMek|q3a+ay-4'0ZjsjTsbTb(b;n)Dvpa`P?{G-L4mmÞھFƆ5@^ U8*8F}E5|"" ,S}g6=ѩ'e;Lv"7 ڕ0aLđ|xnUViY{ *XiRk 2m螗[ +q,-J@)k.?eq\\s0AB>碫qc116o$E+{:xʅѦ!޴z4TMwod 6~Yf}K𭯖#R̚'\V)`9=Ԝ!׀ c7 JbSv!Cǚ O xpc{0t5IS+,]֢1O{Z}+iP< Wo2) '`fge#3Ekp_:?=|",h@X E>jva~6+DuCXb0t (i䵫yGF'S8S-h~yISNL+ ۛNq<|'u,3>mX9 [Lϡ=dQű8vPcBrdE}' Th NFcKnPTTḾ2)U 2aJ}my+6JTUͨ^oMyG5TqhbF%v%VRth՟di; /w ONJMl~l: hpzj&Vh;1s0dpmIӬWNvcVѮ̰/8LEʟyPTm*,/ ku%}_^?4H2,Pp3x`Wej]q`ok*I^0P³FOI-k=e: k7;dhl#=3lb%rql63M7-k4X /r8>AXwjƊ5>'}09\*U^ )dzM°Skw X|gmWU֪*SȈ(4Cm&٬NrޱMw˝NH8թIVڛ4WK+ ԰X=#uRs\XG) sKkZ26 .v#.: ajaiݎ'P㼫g}(maʧ3sT5qN/#M@uF*87@nƇPB1>1atE7q )Y .{X&`qgT`֪Xƺ@m|/Ule5ƇkOèJ$Kuc0~ UaM6= uU~'@`0w6z9iÜX+[^!E.\I**kVsa2(8&"^=Ø5 5QB ;rM.zyj^b5q.z"""-&a麫IZCL"apԨb0źs|yd G nBzjx@V᭛\య±9^f#V`Ѡ}0 u@_GKp pk uihOUĩiaxe~ڑ8 5^Yiqpf{u4X0ĺ*Au@]1C0ΦʟA|})RXjbpsY3D9w|#СBdÏBCUGnR4 :Z4.RcPWbI֐%X BC GZuBES8EǥN2ZNNFT`6USOVG=RqZ .ϕ?7_{W/?xjEbqޓm`s+0|,=L5:5 w~ch_[#v(yCDڮ`5ZӨkly?CX)(A曳CZZ5#u[* #66{g62DsU!\Pn:) 晙@]7h8]YV^t6cR8%M M`ECEjhsW˟(1G&Zp,js!gW<[ЩMS̴ܹ"VFLwaXgHqoRf&Tm`/w8maFX[H:7_C.;C^?l ) Ѫ"$0P=yM\溥7pZbict]Hp=fvoM GK>EP1`7I1Gu7MŵuHE W1ciroUOT{ U*0{#$Z'A@Z#^15ܸNp1N;3>+sFZ ZiɁ<"y3zU^^ 2:cg-V֤Zױn8;"!nn *8 q:qV Na$x/eB1$Aiz. -<Q*|r3WƢ"/<Q*|r3WcͫJ)q~Q'(u_.{;zTVq7@]<Q*|r3W&x]R'6Cߓ\T8_9ez/-h1.G.ɞ G(?>L_9G&ЯG˚4@dLp_9GgQ?_LO9GgQ?_+eqR`=<"S!(0A "r3Sʸx .Wc{Z\k2Wӧh#@b"r3SʹcXe 眏shad <vT"Vt." ԋGv~LO9GX^)GUeIm&'p!ijyf\ԃ Ev<.XWRpi9LtE_կũ9i9s+gQ?\,gL_9GgQ?_LO9GgQ?_#F뽴%0 W1 ZUA4NW Zw~LO9GgQ?\G e:Xj Y1ƋaL)2zPr0g Oʟ&x/ U8b;kߛ@7P1ˀ0 .ɞ G(?]oSEta p'OL_9G 8,9lHr ܥ**UMoqS%HgQ?O<Q*?bibYq#[ 5 ,]ZbF%geo LbibIm\݉q !{Q]qE3?gɞ G(?|j /3gɞ G(?|j /3?gɞ G(?|j뵤Hhsլ:"=cQ?O<Q*xC_QEG9m"W5if]C1Z`8"LO9G'UL#T)hifr$d!^ #ʎ5)Qs iqyf@gQ?O<Q*Cpp괃uǴk ""U5bY\}"r"C7@]<Q*0\?3 [u|Yn1 "wd29/{ \[2 HӪ"jؿ%jҢQTtjqi#^k;!ݣۢ>k>sW?" ^!^5 p̿ڡ+._?EʛP 8O5Y)O%?"<+q4)+UYΩ=|UL8 L8M5?n2АJOxx$Hyc»T`!ݞL13uIw5*nYMĈ9̂^2S /c &ڬVrV iyߗ~5LSp~ ujbV!K2s~k΀]\+tk2=\=7˲υp^f"irDjᢷkΟ'_~tEfV⟇{" R^5hO5E\̩x;gV%` ,Oy7FZ{5@Wԡ0ch; is"ϨNmV c3qf7z'_~t=k. ϊqt)?=菣ޫn?Sٞ"rdq=k󯦧Hjq LOgz9ey"/=k'?_|R V }jBˋA_]{ɿ5ONQֿ:"ᵰx8sygUm|֓Sp V&"/ᝌ\N¿kΟ'_~tE19l}gTT37Y?BϊIPcq,%}>_&_>Oy9FZs?);G ml^IC*Px2?u'.-7o'=k&_kW5+Wz$v"P +Oy9FZ_8l.UT]Y-`|/-U+@^s~Sp^Zn+mIe.36",gqOy7FZi~=azT=ٛ5>G-:<+q5* %Fѥpĉ'_~t=k#qx6Q]SZD@XN8bQ~F4p$:w'?_[O23pjC w@ZyS4Vp o^k[`4<p>Oy7FZ0U@bYvny`x}|L-):Oy7FZ{5@Up}Jcp©mH[*JLC*ch<5;PdԨO4]B=k'?_q).'6Cǔ+ˉ]4FCOwT=k'?_06'TcP4*ai-ͼaqxF&|60WngײvuZ'_~t=k-ʎc: KdɂW/[Hjq LOgG,Ws~.R-M{ܮ'?_>Oy7FZIjXu|ѓ.:3ܣ[Ø+R0ŕ{rN\x+~Oy9FZ{5@[8WwVi+Iu,2@&5ٝHp8^b=U{5ONQֿ:"v/Ø˹v5:lpu2˜=kTs~k΀|2:QGkC\SjV°2X@s_Gu?/.Q~sX5K2/yi qGRjSQ3tEHkΟ'_~tEHkΟ'_~tEKU cLe#B=& tY|s~k΀,gᛉ!3˳kf+8s;Zw1!ZEݣZ F rUo~k΀+*CKv%<ҨĺITo~k΀WŽ KA?nKlyupO1R|o~yMN. n/yia⓲fo"_MQֿ:|o~77S [O mPàAhQq1QC|噛ZH/kΟ'_~tEwWf/ NZwi4 KG.KV#+Ch7h=$;'?_>Oy9FZcWq4T-I/v߄WBH-p-&IΫ_kΟ'_~tEnpÆ+ ZcJKIى 7JM^'hm&r k'_~u|?x?of;?,49@Ԫ"VJou2[&1 nḮ-N_qglT59aazUm %KYuS)s]쇤~dDwZ~U%7@ӰK\^)vѣDUX%$ Ze|#4j5LR89懗R^>qo'OϭQ_ 3G$EcHoj+cD8$b9-RxxfUici<9WKet>*LhN`q\  ~QP7ʀL .7ܽ=x~ʢ""H)a{*u{G=2Xe?Gs)R}Oj О!} SЬ%.=;~ԃQ=p#ժ)N YKV9M")E."8 463Ʊ xacb1 ௺&&b^iak7vD³;?$1 \2Ǧ,luva0!l"WT龍:1RZ>ۼ-.1JkCs{ /u_iFBۍ>Û[>l~>jȩC#6Ԁ"!}ST)Qu8z;U?H9MX|V12*ZPPcr /}q./ Ճqă()nw ]'8fk@C@E爈bKQ[P5 : 1L>-ԩӪj9Rn@Z D(_]WR*s|݀9p50NG6C ܬu@>kH^O TjER6qخy SqjLt v{*qRQ vas:. C1RĊh  ?=|/,g!np8T|875 *tCMےX'eL|6@R.Qًf<'4^% `hnỠ/A_mUiqR5@!ϬZ;Ɲ%W+Pӧ;w n@_ g?r0_[OG-.hRD=r$ILBYW+;tA%ya!?ƾ=}^T?ƾ=pJahuLphss xu&a::uڊXevѭD/EaFOhh5ܮR]KiTVF /S 5^H3 qNcq/~hѥƕFQYG}1ipwTEPWR0t(УT-OzN)Wᅤj531q:; *8=_ɫUggv-K2 CŊDD]~BlSPvTQv"wۙ^L9MrEv SNaK{r|PA @8WpyZ- &:.,4곳IPs3df?7,;@ vĜu18 Fقc5[qvsAy•K8S\|mL5jenFdm|__@\TD@DD@E0}!֦ 6j_!}X:BCPD0vkINe&Fp/H:/y5Q5dSOi{)si>!ag6PA^G ~>Tki kc,u3 u*U)_Rgrr*n_iP*UhHP뱬.' S QDvVu.G \Gn ]J"e0Wq<;in;Z.|gNO[lR.hW7Rǻ AN2l2%N[[a\ nj{#tPB.N &*+ӥB6>W2L~.N & /DDE1) x#ۄût}v-0$g xN4E7P^q Ib=H_yEūˆ̦rU`pHb~mB xu^Tng) "H!}#N u6ӤIݔ~7?y,a( sU÷%?D)@_E>H{f?¹ehf%h7潴ZMMS\7TZ/c>hqaժ"Ɍ{o|y.+*a&20L$uOx \8HٻUG[{ Q:.(*UN,ð2^H%sr-WЩRZʅp VK0܀r`VRCY;3tE(w}S5R7w5s{./emabIu^+Ī[H<B9/,E_!$/+Q / /qf7Nipru(1fK]Bv/+Q /'y_a |Xٳ$̢ƺ$Z|9ag+ y]=,D0!$E|{*IaPy-hzN#r}>>,?!$/+Q / //;١BFuo"eIy[Dg;Joq J5 ^ƲHp ǩ] j5T1Q @Zxk׫S^1ğn.ida\/"`cEqf:u$NWD0w7 5WD) MўPkQ\ o_~l{y]2c%|y-UN?ygH1 lH}ǚ R^E!$/+Q / /gdzq/-˔if^Ae4ڑTXˋt=r!$/+Q / /f;NJ!W< ԭSI)C[Ei#B;W~D0Cb8šuZ6xk@\*?!޾ɟ#'K] %7K>C V$cpjpc @^lKC I^W_@_ KC I^W_@_ 㝇f"=!@sHJo~γk( Q4cbu[eWk)2Kn)1f Я/+Q /'y_a |o)1׸k2684H E q_;kKC& p|_!$/+Q / /jc^,GǶJ=$<}7y_a ?KC H*n^|3 1tpkvB~¢~;J=9J:ʳ;zDy_C^W_O"|KJ:L~Vҩgs(ӫ4Lk 뙀A KC I^W_@_6|}K{6[OE=G@6/kTMBj0۷~p-C׉ \oJm$jQSk4/+Q /'y_a |<DzJ٩H:7Ii!WGSMAI$sv\A-KC I^W_@_7_v'frόt%c[>[J)y|W~D0m{76]FF>Lש^PU~\/+Q /.z`;JktvFbu@֪"y)/&W')ejO8l-n\kzS2bZ~Ip\O5\{i[ɼZ3Sm\×CO>s9;@R2:Ʈ:\h m:+Oxqs{./`gox^?w_E/p0Ś ʄb\#{/Eݩi'Rp>vU|@e;s xjP"n},%SQľN*R{ B =͐Ȣ*47T#8'&}(ZK[<Qc'kJ7]T'6ޤa^iO S ʕk5|i٣hQ}iap`pw֪HP$wJ'Nq{ATE稾崰A԰*j@i64%t90+bTkߚlu6#Ql?? o ð}`{Wu"~,zlJ=F[qT'\E?E!?ƾ=}^?4J*j6ahO@E/ +Uag)v屟WF":8L.-K {@cX@_0ﰘV-Ӭ-ͨkZ`08g`uR%)|J/ppEm^vrq."i9ĸluy gRu' Vd4sLI-S NZݒi7 ;@WQpzoW/B?ƴ.<@+PqX4\a*4Wk7 ¶ +0T"$8 mԳ*`( F '?G[^G [ѥ1|/ÈR±F8bb^kӥI"S4EȾ !\ !&0*Mةp?m:V{kTyr#A/ ?OJyQ]q& p-رRkͩyQ]qEDDDDDDE|. +a]ڹ:Y,u.èV;*@9PS}C'OևFvC0)eO8a&7lhPƢ/mcFZӶ"Y gQ\+u*e:ز@_<9 ӯYCS׽SOqcȼ]`7hܠ(?xj~T}_0\ <=-L3*P5`j-%MtUx<&vS)cΞԀ1}ͧL>0l%j5N%Iui??E)j׭Mه_<\drw0+Qk٤#x] Ky/ 1%?Kܗ AE(CxjoÐ@Jm[xm rуn/sJĐh嘈|R/oOPEU=O3Qevo $8oy /_uMǿc+QSLjAkgF˵|I1@am;r@Ъ"y'o R,mU}^ͅh#X$ZZNTFꘊ!} QR8OJZl^PUe'T T il0DLyKC Sqe527թSI5iS0Ǒ缻kl7 *Ըf)gPuG4H{38|zF5F` D\n!!~!ժSuFȂzӦLm64<"L .7ܽ9x~ʮ -᭩N-!mBFW!qwTc0o}\;YNR{Gf A< gd2B4@_D)ul=*uO0 .M\{2[H1q+M<z-РAZ9?JI+G-\<ƗpmfQ}%/*=*q :o. Fc_53U:>O}5|"" )kHsL{eF&#"\@]>P59Y@D6[ èRyԀpܗ]| /w-t"-*a3ArlqbEL9@pw^PA:k\I}@$E.-L]idZB""Z^SS>zUEhcZ 4xNm&Zѕy \_Lycb=Bbf)gҦjq˝.mLV-qss9#N(ea#)89Z 7 _8Vm6ӧDJ5#Ss xk8vլsXXP0.iŗ;<;_GEDEw0͡KJ[Tq5CLz.gPYƝ73 }@Yg^c?Ǹ/_EyuU=i2Z ©~]t֛]\n^(E<+3 MHsY^NvSwx -S)À.G5կ;8vQQ`9| /oXs\ԩèԦցFgӎD\yIDRObQ4Ma| /wIgٚf@KZ6],wÂQ5W\ֹ3x/[8ExkXSps k+D?yǠ. GꆽRZ]"8\֫[>nծ&Ӡ1] R*U5tsEĆ- r[|~JݦJs:sS4h|W΢"?'( mrܯ\s#MN=csZ3Hy B .7\g5 [;¶%jvc6pDEG1y?WmrjDEeQGx]oтJL.QLg"",_bSEvg:< 64q$Q}Kbaid 4HAm*-1X X繹@i;a2֐ڹEΣjХBRw9""&8x xvaiIe2H/snO5>T\Cit|/ڵ?+Gu?oǎ9Ӫ:sS.cb0>V` 6:s-v{DEwR.cK]6 w-F1zlS$Nw5CH| /yIB@8uS/EW;x,_ o; Fm<){49Y_8I+b_eJώ/aKҡV08ʹ\}SSp/|b?*n@EyB>jo֖g;Xuh(t8֩VTX[$H\74pTۉ--. //o@RJM{vj8m= R9Ԇ1vB􋵕 J>ZL`m% A>+^Q1GT.,89@_<8`F 1akA/!:]wm8'}ߗͧ-WI閖+v0QwP4%:N #%2NV?*Kg c<.u vOqx\-<;rM%͸deデѬxvBcWuh\̕ثP{YMU`s˧OwZA> ҝWp c;hfl1 y#Sq Ѫ"%8xgƻjF*$]3¶sZ)5ٜ Byh>hyc|uj*L]i&n0@-Ip7PƯ&o\7U&LT#D8u0bu@^LIp7S xo?|j/%OO\7TE xo?>Ip7PƢ/\7T%O@_Ip7S xo?|j \_\7U;(p!oRZ |o '.F߂*"_eKQ7ʟ$o~ Q}.F߂*|o '/E_$o~ KQ7ʀ5w/~q+KQ7ʺO9L%z|ZwL3 /kp_:'/'p8)WPýIm|o '/E_$o~ KQ7ʀ5|o '.F߂*"_eKQ7ʟ$o~ Q}.F߂*|o '/[8?$o~ 7:z/k ڬ!IQ!?ƾ=z8Vtp4;*\5_?KQ7ʀ5|o '.F߂*"_eKQ7ʟ$o~ Q}.F߂*|o '/E_$o~ KQ7ʀh8=_ɫALFqY*fac xo?|j/%OO\7TE xo?>Ip7PƢ/\7T%O@_Ip7S xo?Q}թ)\*?!޾o'X+F)CI\8ߓX W֩^&v7 /Ip7V#E`RB/E_$o~ KQ7ʱE`V)_˿ӂlW xo?}G< Y[Š8|uA97m@^JIp7S xo?|j/%OO\7TE xo?>Ip7PƢ/\7T%O@_⛏lW-\7U+g":7>و :Ҫ"|Xy5Z-VXjD?RO;u*}lG\Q\1q 10c}o'0UTT73E<9,ֱuiUh_eOOz_eOOz@g27p,@_u6E~]6cL_˿ӂlʵh)rU^H{f?¹Ӫ"ɞ%It2vc w>ScJ5]lJ'éqO'sXqU dwy5X*9 \m=N(թHSV_ 07X|U}z 喿qkB۩ L>*9ശeN"<?$dSW-@HL3MQ2G(ԊfEJ [a4CC= 0uF62f5_ ¨pjPG{ձm݌$dZuS܀ˇ`8K O922]^9fbFkv5!q8 S);ܬL؈訧i>m<ektE801%|./X:x T,mu]u@_*ܚ}5|"" "" "" "" "" " \_Oo@_ G]#߿J"?=|/,gp Yl?? Ok~O@DD@DD@DD@DD@_wGmM_ܚ}__Vs.z_aj W;ʏm/.*" "" "" "" "" ""-8t-TpW3^Tgj^TgjJ}c wϰ dWSd_wi?S Zw[\'+ESmB~p;°y9Å* s91o o 0*A{CMqL .7ܽ9x~ʢ""K>S碮wKے)ۚT߉A=FJj\et̹8^5vnS01{g\7+0w$ӧ@8 .bǪ"%73u '!1 @Rh ,5J[ SL{[穚kM5-}8& Xg z^(8|.* ^|8s"sfs :X1tQ /)KQ׻&:J|O{0{:m沕6fakD^b؇Z՜cMQ ~=؊;l=GQXf(de\#3}*E3/`sHa7iV+ ;=:cs""aqplS9D}Y0pUߘ KNhS{JJ -pMnSɠ@\9EivtrTʦ xn~KB2ķ斀ryE#NkQ1Cv_/S.+U\]J.tn38mi A&fu.dA'"L.K$2M6LS*:$dxT/'}vmsZD7nT,qk"ez%Z3߈i'ըQt- xc[P5s `|-*X.(SQsh#HilML%V֤a2$H BJ!X̵@=Pz1:=,3ϧ4;hLISécaژ6Ǝ|7%q+Co,ʔNFāq#8pY-jMf7 VңNՠjXH,?81QYi05;qGVAYcj3^.ƹT-,.%y"6FiҧMRIgr:D.8]jjXyh>BA0Lmj 0K7;nЮϓR?pT c)9YI$i/1ίkp_:8 ^V̸jUSU)u Cɹs4i~j1Ю#De'WDFn-F)5K^8qWin[F|,-W<\+'^s *ҥ:5`ps 궪UWsD6% Rw, @_ZxN Q}:Xzc2LTt_5pLq8sV@HSZH$: Ӯ ,}6h6Y2eP/f9/]!w]khP5\ڔsԟDEXS jXzHWR$ԹW){f ,i$g%Zq,F豏POC/|z|z"/t::z*{Ľ,2|ax/AzELÜƹrN8 ,bhv"l- Z鲝BA5=헳! e?GI_:%^viFW5ad<,i{skHQԩp5줂]?4bY}JxgφiNQYSZ)ԧp`8a|nXU㸪,S2)LnhOz",V`GSk} .}ZFJzضkmpNChrHU5*"$ִ5h ,7_RI*/}&i"4Cm&٬Nt Ηޱ5.v:I:\ "p,=,F%ƨ:kqn%la1upU[ZzuM*mT_W1~Է5a(hTj?6yleinsTm'@4fF-VoꔪɂMm#\ @]`(aq J&: 9\f4LLzxl q*50sH uwT)@hd VZʕS=Z-{)p8|ps/@ԊKrmL/E|% py|l;6Nįqn̠i :$*qMFSXVQcC<K} zXjm`z. x_Gu?w#_q!=EyQ]qEDDDDDD__^ͪa `Qös.t x5vafFٷ;!tI "*tQV5+WLegJ NvPc\z*+ezKX5M`I8|Ck;Oz cu-bUx|mᱎ\92C JsT9.^ p4EQvb+QmK{WZLkS9k3tAhKhд\Ox{4/?xj^Tgja  RDD\4^B`0Z @:h0 XVQT"H His 1H@"XB& qH "`X'.kAx <0,@4h'^ Q"bAS` [}rXęZ.r偮'ֶp4Ax) ŰF @`h`x E<+ JcH2$g,$Ah V @`2ԃx@`X @`0)b 0`bZⒼ `x I[@`1X΄_- Eb/$܀PJ r `)^by)`p/V@`N ϰRE`49H#5o $`x @4 8)c^ A8 @`x  @ @4 bȺ@SR ~0.r 27G;1&B@"- `:Pk@ZXAX%@`0F"b=ϰ d @V4Wp eϰ d;(e}ߗͧb|"" /ݖKӮm,[$kQRc*QA4ZcAhp->$TcjFL Jg򚍩>A6;} 00 aEfy)J= M{aSSaö|#ұ/`>2גeku,&@_K[J ?\M,܀L靂gfh7Y-sXt rqmL9øܮٷsFΩZXWYꆆS9 dEU \$81Orpz}&2;ieD|e^?īԧR!_I/uH:1ժ"~#Ku،qUňmaSӮS a C_Qŭqp;:8Wis<ꡀH /8PkZ4D6@\qMzQ+ oIi-yC]vv*!sO%H qa* $ʩ"^$v' JbDf'bJo_VD)V#ʊ?Gvc]$7ժ&a47/q&Lo8si4t4$.+E ۭa ;uWAKK U#ɨFE|Ĵx @i&+&;Uǵxph|Ϟ`˿s}w]o|" "" "" "" "?[mrjEtEx'qV_s?Kµ|2" "" "" "" "_`>Ww/~q(?,g輳/1Π"" "" "" "" "7x-en0@_O!?ƾ=}^?4DDDDDDDDDDDDEt8=_ɫ_aj W;ʏm/_Vs.z"""""""""""""""""уBkAKhxݮs>h_eOOz_eOOz@g27p,@-_u6E~]6cL_˿ӂlʵh)rU^H{f?¹֪"Ɏ#Ku،&,Cnnf":a94!I%N =&K|ꡀH 侖.j*{r||/v$nq#0; 㿵\MzM ^My9*v1U8 h:-7 `:c6EvJ?vS%(Wde2Qgox^?w_e,IN'U.\i x(},?O/?Yb~|#E(Q},?O/?Yb~|#E(WpzoT~|NT18d>G"_uEG?Sؠ/E__$?hHQg"T_uEG?Sؠ/E__$?hHQg"T_uEG?Sؠ/_s?KµO,?_EhVS-t dEhا,?@_ hHQg~|Eا,?@_ hHQg~|E}]/?Yb|y5Cja8bRYL4 /kp_:?&,ELg}pL4 j#E(Q},?O/?Yb~|#E(Q},?O/?Yb~|#E(V},?V?IQnD@Zxk׫S|q'AzHhg)\//?Yb~|#E(Q},?O/?Yb~|#E(Q},?O/?Ybܚz8N?18peKhHQg"T_uEG?Sؠ/E__$?hHQg"T_uEG?Sؠ/E__$?hHQg" jw__u { Tb1?-2{ W&kqULW}*a(Q},?O/?Yb~|#E(Q},?O/?Yb~|#E(Q},?O/?Yb~|#E+F*] EEj Z5Q7k)Wx 1{QI@De#E+@k#^U^C֧8_ hHQg~|5^HY`'U=i/E__$?hHQgHY`'U=i/E__$?hHQgHY`'U=i/E__$?hHQgnY4^ZRlavmX/_wk?_$}'?(;xxCIo}bi`~|#E(Q},?O/?Yb~|#E(Q},?O/?Yb}ג?7ُO/?Yb;0v+6 1@ת"ɬ[p^LWLEzFCtVpn:p6wC_ m:8 "64_I_]Z2^!K .@貞fs[M$ ,Eò*14\ 6 滝NN&;BIhG"'h4]RWHo܀3M0ȐIZS;8TQŵXb8 iu3`2w_GC`0兔jo.sIqyW,ViUL5'أ:ije\3C="lRwT)n k2n'8fGS}3hN(v.Ӥe\%V|C(զچIj~p PokC] uLa99@Zq=1JbZ^0&5XU8x684ёrA]GSQ- -qkp0f)ďNĞP;ahbT 5^Yw_X,5,)ТܴD גw]o|"n]JZkVv22eSiR5iH+BlMn$0U)d-dr" (m. ah$COojҭE݊ /''d+QZ~(!8}; ;iڧ/j* G@^~G0x!B s>&M[T*a~O b<,7.mg^c?Ǹ/_EyuVuv쩸MF5s},Mm ey7vsp[08ZIyͣ@|/apjWCMj[ -~!Z|=0p78Ud-)9"t_z1=e\jLlsS&f9 O[WQꚍf\íw?l?ķZTKF *Miiu{7µؤ̯$K^~<Ġ-i5?D?yǠ"/ʍ\K)ӫTէJ*8 ~Ҷ 鰺M~IQ8WqJo8>lkX$5[i *Т;V8/j2Nh@_otl6g{_T\kV]HWVaWhRZZd/=EF3UHT:".c/b# NjQ~SZ׆sZ8=_ɫ޳kmA|""ԙ_BOW{Wk>:O\i̒a|/_jPUsF;a{^;lTPu&Uk_fJo؂#XEJ)~3 BLE7Ӥ@'Gz2 |%Ĝ#qa˘0Eh 0UժR/kI ƧT}kСHRVK# ډ@ZAZ•K. a8 þ+4͑3ʏm/.*" "" "/5趍*ƚO3HNѭXUjPm7.JԳc+yˢ qz.4Tk\TshG?͘cEk۔g/X@_zw ,KTW GܲZ@sXW c)baYO~&,k39K />E-|EcB }F KX9K'E_/7mgkW#"?xjU rXz_Ep0MJ,VԨ2^;Q}_mBGcVj,lʄCOy[|5ñ#T,mHa] (Q} ~*M`2ځ_窷UzK0{ Og /E茢&.'Ycpi1p "K0,p 9ڹ:5-$u>kFJ"U~]6cL\n g5T`5^dFum8'vx Z藱ۼȻq%Z;Zl}JLNWSÛ1Waai}*-/+ $/E^ XVWe8\]|! ,^[ F}_9ebULdP"8 3&)s3y[⸬E3L26tDg9jQ싙XzKo pJFG @[hgox^?w_ .7܀Utg^ڈpsC\@]|'8N֛_]d|t]؃/qtFE V|=l3*ۮI|]'X&z,uPiRDH\t@]WKRZ@u yAı5 ʄhblDES*Yu݄._[GmM_ܚop)Ul3^ZAP~Yq Wyg^c?Ǹ/@E3 uC+ҡEAf2 m3V8+"Hӹj""軍q߉U[ʎ)[Kꣴa  .< 5*$i 2ӥSUl`<Ļ[h6KZ?~;'WCP::Ԡ8]k+gO`C/|z|z"p/{ 5uncYZ@%}sN+yS[L,6 Y!1'_KX\@[ m.;|~] QcUUl  : .ʹs%p.z_aj W;ʏm/.*" "" .c8ZJ52ѫ9h$MRn<n#^Im5\D@[Mbk8EC+mw=1{E*h h24@""c|xLԭE;F4<+2:N\t@]?S RFVvf5yE,AzaWwNDJ /?xj~T}_Gc7`V(;QP Cn#R'=#ٷ6c#N"0~b*4Q,ƇDE֫|=3J(GLx*n2b; av^$4d):U6b%,i|XtH\D@[ ֧J) s#E]6cL_˿ӂlۈû-Fv حD@[+ÍW;9?j潵19FEsGúls4=$Yk8zf<W$:ZZ .ǻ K " @cA0df1'N/.!FgƵ7- ")xh;R##rG, p(1ݞNE)rҪ"ɾ$Ƈױh. . )sQ;$QN .#Ζd\r.z5\S d45s^yaxvUchyb\8 mTgU>@04YGdmNK9Pa](өZL3dqWivm: #X tIuտpfnOX ˚t@[4_M:ĬխA48-(|]u^!d/=~'UuZ5nf2f@^di^IQ:OWN!Ƣ/WN!~DE~Dy'D|j/y'D?i^IQ:@_ܚi^IQ:_OO(eS85?L?0XӪ"d_eJO?"~ҼuȀ5~Ҽuȟ$C /E_$C'+?'_Q}+?'_JO?""_eKO?"~ҼuȀ5}q./ G+?'_xvq Tq_uQ,5,]yB/y'D?i^IQ:@_i^IQ:O_N!Ƣ/WN!~DE~Dy'D|j_`>WO~E9Ga= n6&,k?=|(%}j5ˆf6#~DE~D'D|j/y'D?i^IQ:@_i^IQ:OWN!Ƣ/WN!~DEgO`~Evy,M>%]YvZ_C/|z/+p<{+l2f$C /E_$C'+?'_Q}+?'_JO?""_eJO?"~ҼuȀ5~Ҽuȟ$C -?WmrjE4|y1RU8:_ e:y'D|j/y'D?i^IQ:@_i^IQ:OWN!Ƣ/WN!~DE~Dy'DQ}թ)\*?!޾l8qk ~Zo׼-N7üıo 뺻r"/WN!~DE~Dy'D|j/y'D?i^IQ:@_i^IQ:OWN!Ƣ/WN!~DE~DĹp3 }[89}Vd~\- qo22#6vNCX5DEԼV}jt[ـ7~J.>q)SaװT%w8!}N>37 <3{Iۭ ~@EDZW UHԭJ5sH$)`5Tg3 ]:!؜]:( DL|š5H{ 42-1dE .7ܽzr m&rܼ˿s}VMcA=V+."kaLVm7ԒedL47ael]i-Xn'Ạkɭ-l9p$yE$5 0Zpc־qSclzq,U|*zx@`66Đ@@_9< k`O .ÈWTkjy'- ` 0h quN)X6-jfZ$74 S{F pzoWV7`bsf*jAgS9A!HZĝ-LX /;DDDR֗h$YѤI O_a!>O@Y5qOA+| \#bJ=UfaHN5,{em"|k`O $A26^v_c*5a4_Əv6ĜK Ir:3AY234D/yq[<ֆ $γ3F`M굁D Au..6q)a4bi!uUpwJvpzoW/oۿ܂$DY9oO1 kSeln>c+kSwĖ0 99X E0t1ds8_mPQ0jTDctbI=IWc5=wcCP{3L@_9I31ٻX95Hn_Zo4CrnzolKH$r;AR!]*a1cy p $Z-a-ZK1A 4 h%|ef8WUmL>Pg-&plV>Ԯqs I@ZT}_ʋp^?*ھ1A x} G b0[^E$Mj1żǭ}ok_iS~l5H{/lt7 k9Ȣ&:E-3bg,y/,p`bټ2:2kb0-tѭQ2R1sYd;nB"AJ%$j vo}lm޾ŜSxJkbC & sV)թIjS:E"干ǭ}חͧj~Tja{ z˯ӂl\` '`I|+TS5ۅ)nmX$ĀN-0DEI I:{>uTc]Qs`9߿.zъn*6ROM(q0Hi"QMdj 8CIS_zE|;Yu6֊` O@<=ǵi~\` |'9#/+Z\e.UjT4HH N_a꿅ԫN@3@&PȖ8QR$[p 1]'a{kbhPshI)$, υg@ Ԫ"lhy:3U.axl}k(TufRZy=k㼙 8>$I&ݓs2O)| Rk/fPԢ\ȣ /E,ߑO.w@_@Yp?? "|X~DEL .7ܾY0AN_qTŻԤ^0tG[ /[/y֯gp k~ҼW~Ty=E*#{TSys]s2LI[xo(x4;3Sc&y=E*J{U]P ;\T|h.`8SnsgK͗~ҼW~Ty=E*"McQ@h/M1[m@je 1.+)WewOWRʀn?İe\־q_PǺ8˝N乫J{U]Wq!ջN:|9/][3'_ߕ?i^OQJ+*"{<'΀]ma; v&XÜZH.+)WewOWRʀuxP'=2bZ#n3V? $ri^OQJ+* q|4c8byNhTAb~ҼW~Ty=E*[qGf*V)h,lis=_3ubh} c4Lty=E*J{U]P ϱ=:)eYtvBܷc cW._by=E*J{U]Pqx}J ~V4g*h0~7ui^OQJ+*~ҼW~TEV{i%`'x7q15MAN 7` =J2Opu `5j͐&k'"g^c?Ǹ/_qY8:-F3TabѬy=E*}?+)WewOWRʀu8N7.eŴ_V2h|6໿'_ߕ?i^OQJ+*"b8;fb4 la$RwĹԞj Ey=E*J{U]P#=9ōqV1\$kX.y=E*J{U]PL YQk.vzl|iy=E*J{U]P#ruW+&c!yB~ҼW~Ty=E*>?v*rT Ky4>T\Ci}wx M0#[8qn#xV\ "_OJ{U]S2/E'_ߕ?i^OQJ+*"a;XI[$H*q-|Tk2z$DX.+)WewOWRʀT>jur|skFoj}J :e41I+J{U]S2.}(!ԝR&0 l hh'.'uɖr3.^Y#/t?i^OQJ+*~ҼW~TEͥk2=2Z<q U`ׂ {Gec2+)Wew@[T}_)-[Dߴ'_ߕ?i^OQJ+*"7bQ[S+̄KtGX d %}+)WewO_Rʀ586)0Ն 5eۡ9@[n(j鱥2Էi^OQJ+*~ҼW~TEqn*kRXY-cD4u'41fvi^OQJ+*~ҼW~TEwǻ }" Z4ȸ_Si??y?E*1\RS8fù٬ /<[8`-i|Ws2+)Wew@\8 XCZFX_Y"/yAZ? eUˏK{U]W_#q,= c1tևPs9H4 endstream endobj 1819 0 obj <>stream endstream endobj 1818 0 obj <>stream endstream endobj 1809 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\034\002\025\202\001\025)21(\222 \006)-10(\026)11(\016\221\016\001\220 \221\025\r\002\016\217)-20.9(\201\016\001\220\203 \026)11(\013\222\025\r\025\202)10.1(\025 \201\001\013 \r\022\007\016\017\016\001\220\220 )]TJ 0 -1 TD [(\221\025\006)-10(\026)-31(\026\002\013\r\024\013\026\220\017\016\006\n)10(\025\202)10(\025 \013\001\013\007\216\001\025\202)10(\025 \001\016\201\016\002\217\013\001\220\205)]TJ 42.45 1 Td [(Pr)20(ognoses of injur)-30.9(y scale in sur)31(gical tr)31(eatment )]TJ 4.112 -1 Td [(of post-tr)21(aumatic anal incontinence)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0.005 Tw 10 0 0 10 274.9606 603.0499 Tm (\211)Tj /Span<>> BDC ( )Tj EMC (3)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\022 \r)Tj /Span<>> BDC ( )Tj EMC (\030\026\027\027\036\n \023\024\f\035\036\024\023\036\030\026\006\017\024\ \027\027\024\n \023\036\030\017\024\007\036 )Tj -0.011 Tw 0 -1.218 TD (\002\t\035\017 \r\t\016\r\035\036\027\t \024\f\035\024\032\027\036\027\017\ \016 I \017)Tj /Span<>> BDC ( )Tj EMC (II \f\021\036\023\036\027\017 \023\024)Tj /Span<>> BDC ( )Tj EMC (\022\035\026\f\f\017)Tj 0 Tw (-)Tj 0.013 Tw T* [(\235\017\022\026\006\017\017 )0.5(Cl)-16(av)-16(ien-Dind)-15.9(o [10,11] \(1 )0.5(\020\036\n\026\021\024\n\026 \r)]TJ /Span<>> BDC ( )Tj EMC (\024\002\035\026\f\021\017 )Tj 0.143 Tw 0 -1.218 TD (\024\023\036\030\026\006\017\017, \023\024\021\030\036\002\024\r\026\r\001\ \026\016 \022\024\027\f\036\030\r\026\021\017\r\027\024\020\024 \035\036\ \004\036\027\017\016 )Tj 0.212 Tw 0 -1.218 TD (\017)Tj /Span<>> BDC ( )Tj EMC (2 \f\036\030\024\n\t \023\024\f\035\036\024\023\036\030\026\006\017\024\027\ \027\024\005 \030\026\027\t, \023\024\021\030\036\002\024\r\026\r)Tj 0 Tw (-)Tj 0.343 Tw 0 -1.218 TD [(\001\017\036 \007\030\036\027\017\030\024\r\026\027\017\016\). \221\030\036\ \007\027\017\005 )0.5(\023\036\030\017\024\007 \027\026\002\035\033\007\036\027\017\016 )]TJ 0.178 Tw 0 -1.218 TD (\026)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\026\n\017 \f\024\f\021\026\r\017\035 7 \n\036\ \f\016\006\036\r \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\n\026\022\f\017\n\026\035\034)Tj 0 Tw (-)Tj 0.056 Tw 0 -1.218 TD (\027\024\n \023\036\030\017\024\007\036)Tj /Span<>> BDC ( )Tj EMC (\227 4)Tj /Span<>> BDC ( )Tj EMC (\020\024\007\026. \221\030\036\007\027\017\005 \002\026\035\035 \r\t\030\ \026\032\036\027\027\024\f\021\017 )Tj 0.1 Tw 0 -1.218 TD (\026\027\026\035\034\027\024\005 \017\027\022\024\027\021\017\027\036\027\ \006\017\017 \023\024)Tj /Span<>> BDC ( )Tj EMC [(\001\022\026\035\036 W)22(e)-18(xner \f\024\f\021\026\r\017\035 )]TJ 0.111 Tw 0 -1.218 TD (13 \(SD)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (3,5\). \215\030\017)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\n \017)Tj /Span<>> BDC ( )Tj EMC (\026\027\026\n\027\036\f\021\017\004\036\f\022\017\b \007\026\027\027\t\b\ )Tj -0.035 Tw T* [(\f\035\036\007\024\r\026\035\024, )0.5(\004\021\024 \021\016\032\036\f\021\034 )0.5(\030\026\030\t\r\026 \023\030\024\n\036\032\027\024\f\021\017 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC (\030\024\007\026\b )Tj 0 Tw 0 -1.218 TD (\027\036 \024\021\030\026\032\026\035\026 \021\016\032\036\f\021\034 \023\ \024\f\035\036\030\024\007\024\r\024\005 \017\027\022\024\027\021\017\027\ \036\027\006\017\017.)Tj -0.003 Tw 0 -1.218 TD [(\221\030\036\007\027\017\036 )0.5(\023\024\022\026\026\021\036\035\017 )0.6(\017\027\022\024\027\021\017\027\036\027\006\017\017 )0.6(\023\024)]TJ /Span<>> BDC ( )Tj EMC 16.433 0 Td [(\001\022\026\035\036 )0.5(W)22(e)-18(xner )]TJ 0.023 Tw -16.433 -1.218 Td [(Incont)-32(inence S)-24(cor)-24(e \017)]TJ /Span<>> BDC ( )Tj EMC (\022\026\004\036\f\021\r\026 \032\017\027\017 \023\024)Tj /Span<>> BDC ( )Tj EMC (\001\022\026\035\026\n FIQL )Tj 0.117 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (PISQ-12 \007\024)Tj /Span<>> BDC ( )Tj EMC (\r\t\023\024\035\027\036\027\017\016 \r\n\036\001\026\021\036\035\034\f\021\ \r\026 \f\024\f\021\026\r\017\035\017, )Tj 0.172 Tw 0 -1.218 TD (\f\024\024\021\r\036\021\f\021\r\036\027\027\024, 13 \(\261)Tj /Span<>> BDC ( )Tj EMC (3,5\), 1,9 \(\261)Tj /Span<>> BDC ( )Tj EMC (0,5\) \017)Tj /Span<>> BDC ( )Tj EMC (17 \(\261)Tj /Span<>> BDC ( )Tj EMC (6,8\). )Tj 0.222 Tw 0 -1.218 TD (\215\024\022\026\026\021\036\035\017 \024\023\017\f\026\021\036\035\034\ \027\024\005 \f\021\026\021\017\f\021\017\022\017 \023\030\036\007\f\021\ \026\r\035\036\027\t )Tj 0 Tw 0 -1.218 TD (\r)Tj /Span<>> BDC ( )Tj EMC (\021\026\002\035\017\006\036 1.)Tj -0.012 Tc 0.081 Tw 0 -1.218 TD [(\222 \021\026\002\035\017\006\t \r\017\007\027\024, \004\021\024 \023\024\ \f\035\036 \b\017\030\031\030\020\017\004\036\f\022\024\020\024 \035\036\ \004\036\027\017\016)-12( )]TJ -0.057 Tw 0 -1.218 TD [(\r\f\036 )0.5(3 )0.5(\023\024\022\026\026\021\036\035\016 )0.5(\r\t\030\026\032\036\027\027\024\f\021\017 )0.5(\026\027\026\035\034\027\024\020\024 )0.5(\027\036\007\036\030\032\026\027\017\016)-11.9( )]TJ -0.005 Tw 0 -1.218 TD (\017)Tj /Span<>> BDC ( )Tj EMC (\031\030\024\r\027\016 \022\026\004\036\f\021\r\026 \032\017\027\017 \031\ \035\031\004\001\017\035\017\f\034, \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\n )Tj /T1_2 1 Tf 0 Tc 0 Tw (p)Tj /T1_1 1 Tf -0.012 Tc 0.012 Tw 19.687 0 Td [(-v)-15(al)35.1(ue)-12( )]TJ 0.075 Tw -19.687 -1.218 Td [(\007\035\016 \r\f\036\b \021\030\036\b \027\026\004\036\027\017\005 \f\024\ \f\021\026\r\017\035 \n\036\027\036\036 0,05 \(\030\026\027\017\006\026\ )-12( )]TJ 0.101 Tw 0 -1.218 TD [(W)22(e)-18(xner)]TJ /Span<>> BDC ( )Tj EMC (\227 <)Tj /Span<>> BDC ( )Tj EMC (0,01, \030\026\027\017\006\026 PISQ-12)Tj /Span<>> BDC ( )Tj EMC (\227 <)Tj /Span<>> BDC ( )Tj EMC [(0,01, \030\026\027\017\006\026)-12( )]TJ 0.008 Tw 0 -1.218 TD (FIQL)Tj /Span<>> BDC ( )Tj EMC (\227 <)Tj /Span<>> BDC ( )Tj EMC [(0,01\). \212\035\016 \024\006\036\027\022\017 \023\030\024\020\027\024\f\ \021\017\004\036\f\022\024\020\024 \r\035\017\016\027\017\016)-12( )]TJ 0.014 Tw 0 -1.218 TD (\023\024\022\026\026\021\036\035\036\005 \031\035\034\021\030\026\r\031\ \022\024\r\024\005 \007\017\026\020\027\024\f\021\017\022\017 \027\026)Tj /Span<>> BDC ( )Tj EMC (\030\036\031\035\034\021\026)Tj 0 Tc 0 Tw (-)Tj -0.012 Tc -0.044 Tw 0 -1.218 TD (\021\t \035\036\004\036\027\017\016 \023\030\024\r\036\007\036\027\026 \024\ \006\036\027\022\026 \030\026\027\017\006\t \n\036\032\007\031 \027\026\ \004\036\027\017)Tj 0 Tc 0 Tw (-)Tj -0.012 Tc 0 -1.218 TD (\016\n\017 \024\006\036\027\024\022 \022\026\004\036\f\021\r\026 \032\017\ \027\017 \007\024)Tj /Span<>> BDC ( )Tj EMC (\024\023\036\030\026\006\017\017 \017)Tj /Span<>> BDC ( )Tj EMC (\023\024\f\035\036.)Tj 0 Tc 0.017 Tw 0 -1.218 TD (\215\024\f\035\036 \023\030\024\r\036\007\036\027\017\016 \022\024\030\030\ \036\035\016\006\017\024\027\027\024\020\024 \026\027\026\035\017\026 \017\ )Tj /Span<>> BDC ( )Tj EMC (\024\006\036\027)Tj 0 Tw (-)Tj 0.08 Tw 0 -1.218 TD [(\022\017 )0.5(\f\021\026\021\017\f\021\017\004\036\f\022\024\005 )0.6(\027\026\004\017\n\024\f\021\017 )0.6(\030\036\031\035\034\021\026\021\024\r )0.6(\002\t\035\024 )0.5(\024\002)]TJ 0 Tw (-)Tj 0.222 Tw 0 -1.218 TD (\027\026\030\031\032\036\027\024, \004\021\024 \036\007\017\027\f\021\r\036\ \027\027\t\n\017 \023\026\030\026\n\036\021\030\026\n\017, \n\036\032\007\ \031 )Tj 0.385 Tw 0 -1.218 TD (\022\024\021\024\030\t\n\017 \031\007\026\035\024\f\034 \027\026\005\021\ \017 \f\021\026\021\017\f\021\017\004\036\f\022\017 \027\026\004\017\n\031\ \033 )Tj 0.533 Tw 0 -1.218 TD (\022\024\030\030\036\035\016\006\017\033, \024\022\026\026\035\017\f\034\ \023\024\022\026\026\021\036\035\017 \001\022\026\035\t PISQ-)Tj 0.125 Tw 0 -1.218 TD (12 \023\024\f\035\036 \035\036\004\036\027\017\016 \017)Tj /Span<>> BDC ( )Tj EMC (\001\017\030\017\027\t \035\036\r\024\005 \027\024\032\022\017 \035\036\r\ \026\021\024\030\026, )Tj 0.074 Tw 0 -1.218 TD (\026)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\032\036 \030\026\027\017\006\t \023\024\022\026\026\021\036\ \035\036\005 PISQ-12 \f)Tj /Span<>> BDC ( )Tj EMC (\026\027\024\030\036\022\021\026\035\034)Tj 0 Tw (-)Tj 0.233 Tw 0 -1.218 TD (\027\t\n \031\020\035\024\n \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\027\026\021\031\032\017\r\026\027\017\017. \200)Tj /Span<>> BDC ( )Tj EMC (\024\002\024\017\b \f\035\031\004\026\016\b \r\036)Tj 0 Tw (-)Tj 0.151 Tw 0 -1.218 TD (\035\017\004\017\027\026 \022\024\220\235\235\017\006\017\036\027\021\026\ \022\024\030\030\036\035\016\006\017\017 \f\024\f\021\026\r\017\035\026\ \024\021 0,3 )Tj 0.26 Tw 0 -1.218 TD (\007\024)Tj /Span<>> BDC ( )Tj EMC [(0,5, \004\021\024 )0.5(\f\024\024\021\r\036\021\f\021\r\031\036\021 )0.5(\f\035\026\002\024\005 \f\017\035\036 )0.5(\022\024\030\030\036\035\016\006\017\017 )]TJ 0 Tw 0 -1.218 TD (\(\230\026\002\035.)Tj /Span<>> BDC ( )Tj EMC (2,)Tj /Span<>> BDC ( )Tj EMC (3\).)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 275.0305 115.9298 Tm [(\037\036)10(\032\223\212\226\034\022\031\034)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0.004 Tc 0.872 Tw 10 0 0 10 274.9606 91.5738 Tm (\215\024\035\031\004\036\027\027\t\036 \030\036\031\035\034\021\026\021\ \t \031\022\026\t\r\026\033\021 \027\026)Tj /Span<>> BDC ( )Tj EMC (\024\021\f\031\021)Tj 0 Tc 0 Tw (-)Tj 0.004 Tc 0.658 Tw T* [(\f\021\r\017\036 \023\030\024\020\027\024\f\021\017\004\036\f\022\024\005\ \027\026\004\017\n\024\f\021\017 \023\024\022\026\026\021\036\035\036\ \005)4( )]TJ ET q /GS0 gs 221.1023475 0 0 357.9409407 42.5196833 244.8723019 cm /Im0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 0 Tc 0 Tw 10 0 0 10 263.622 241.3959 Tm ( )Tj 0.151 Tw 9 0 0 9 42.5197 230.5959 Tm (\022\t\217\210\b\002\220 9.)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf ( \230\004\n\202\032\026\003\003\026 \026\021\026\023\022\021\n\202\n \013\ \026\021\026\023\026. \201)Tj /Span<>> BDC ( )Tj EMC (\227 2D \230\212\214\221\215, )Tj -0.018 Tw 0 -1.2 TD [(\033\032\n\030\n\023\022\021\n\031 )0.6(\t\031\006\031\021\025\031. )0.6(\213)]TJ /Span<>> BDC ( )Tj EMC 9.423 0 Td [(\227 )0.5(3D )0.6(\230\212\214\221\215, )0.5(\t\026\202\025\024\024\026\023\022\021\n\031 )0.7(\t\031\006\031\021\025\031. )]TJ -0.012 Tw -9.423 -1.2 Td (1)Tj /Span<>> BDC ( )Tj EMC [(\227 \t\024\031\021\013\026 \021\025\204\021\031\026\003\033\205\023\002\ \032\021\n\202\n )0.5(\n\024\030\031\023\026 \033\032\002\003\n\017 \013\025\001\013\025, 2)]TJ /Span<>> BDC ( )Tj EMC (\227 )Tj -0.033 Tw T* (\027\021\205\024\032\031\021\021\025\017 \t\f\025\021\013\024\031\032, 3\ )Tj /Span<>> BDC ( )Tj EMC (\227 \f\032\026\202\003\031\021\024\020 \032\031\013\024\n\027\026\202\025\ \021\026\023\022\021\n\017 )Tj 0.091 Tw T* (\033\031\032\031\202\n\032\n\030\013\025, 4)Tj /Span<>> BDC ( )Tj EMC (\227 \033\032\n\t\027\031\024 \003\n\006\031\027\n\202\n \033\205\016\020\ \032\002, 5)Tj /Span<>> BDC ( )Tj EMC (\227 \205\032\031\024\032\026, )Tj 0.173 Tw T* (6)Tj /Span<>> BDC ( )Tj EMC (\227 \033\032\n\t\027\031\024 \027\023\026\202\026\023\025\211\026, 7)Tj /Span<>> BDC ( )Tj EMC (\227 \030\031\f\031\013\024 \024\013\026\021\031\017 \033\031\032\031\030\ \021\031\017 )Tj -0.005 Tw T* (\t\024\031\021\013\025 \026\021\026\023\022\021\n\202\n \013\026\021\026\ \023\026 \025)Tj /Span<>> BDC ( )Tj EMC (\016\026\030\021\031\017 \t\024\031\021\013\025 \033\032\031\030\030\027\ \031\032\025\002 \027\023\026)Tj 0 Tw (-)Tj T* (\202\026\023\025\211\026)Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 0.051 Tw T* [(F)-16(igure )0.5(9)32(.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf [( Echog)14(ram )0.5(of )0.5(the anal )0.5(canal. \201)]TJ /Span<>> BDC ( )Tj EMC 16.343 0 Td [(\227 2D )0.5(ER)27(US, longitu)]TJ 0 Tw (-)Tj 0.058 Tw -16.343 -1.2 Td (dinal section. \213)Tj /Span<>> BDC ( )Tj EMC [(\227 3D ER)27(US, sagittal section. 1)]TJ /Span<>> BDC ( )Tj EMC [(\227 w)13(all of the )]TJ 0.006 Tw T* [(low)12(er am)16(pulla of the rectum, 2)]TJ /Span<>> BDC ( )Tj EMC [(\227 inter)-13.9(nal sphincter)61(, 3)]TJ /Span<>> BDC ( )Tj EMC (\227 frag)Tj 0 Tw (-)Tj 0.087 Tw T* [(ments of the rectov)16(aginal sep)13(tum, 4)]TJ /Span<>> BDC ( )Tj EMC [(\227 lumen of the bladder)61(, )]TJ 0.091 Tw T* (5)Tj /Span<>> BDC ( )Tj EMC (\227 urethra, 6)Tj /Span<>> BDC ( )Tj EMC [(\227 lumen of the v)16(agina, 7)]TJ /Span<>> BDC ( )Tj EMC (\227 tissue defect of )Tj -0.005 Tw T* [(the )0.5(anter)-37(ior )0.5(w)13(all )0.5(of )0.5(the )0.5(anal )0.5(canal )0.5(and )0.5(the )0.5(poster)-37(ior )0.5(w)13(all )0.5(of )0.5(the )]TJ 0 Tw T* [(v)16(aginal v)13(estibule)]TJ ET 1 0.68 0 0.12 k /GS0 gs 42.52 480.109 21.907 21.907 re f BT 0 0 0 0 k /T1_4 1 Tf 11 0 0 11 50.2666 487.075 Tm (\032)Tj ET 1 0.68 0 0.12 k 42.52 244.897 21.907 21.907 re f BT 0 0 0 0 k /T1_4 1 Tf 11 0 0 11 50.2721 251.8628 Tm (\225)Tj 1 0.68 0 0.12 k 9 0 0 9 42.5197 730.483 Tm (\020\004\206\f\t\204\004 1.)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf ( \n\013\026\016\026\024\031\023\025 \n\033\025\t\026\024\031\023\022\021\ \n\017 \t\024\026\024\025\t\024\025\013\025)Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf T* [(T)48(able 1)47(.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf [( Descr)-36.9(ip)13(tiv)13(e statistics)]TJ ET 0 0 0 1 K 0.5 w /GS2 gs q 1 0 0 1 42.5197 715.181 cm 0 0 m 79.62 0 l S Q q 1 0 0 1 42.7697 703.9617 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 122.1398 715.181 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 122.1398 703.9617 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 184.502 715.181 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 184.502 703.9617 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 246.8642 715.181 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 246.8642 703.9617 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 309.2264 715.181 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 309.2264 703.9617 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 371.5886 715.181 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 371.5886 703.9617 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 433.9508 715.181 cm 0 0 m 62.612 0 l S Q q 1 0 0 1 433.9508 703.9617 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 496.313 703.9617 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 42.5197 703.7117 cm 0 0 m 79.62 0 l S Q q 1 0 0 1 42.7697 692.5005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 122.1398 703.7117 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 122.1398 692.5005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 184.502 703.7117 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 184.502 692.5005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 246.8642 703.7117 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 246.8642 692.5005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 309.2264 703.7117 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 309.2264 692.5005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 371.5886 703.7117 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 371.5886 692.5005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 433.9508 703.7117 cm 0 0 m 62.612 0 l S Q q 1 0 0 1 433.9508 692.5005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 692.5005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 692.2505 cm 0 0 m 79.62 0 l S Q q 1 0 0 1 42.7697 681.0392 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 122.1398 692.2505 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 122.1398 681.0392 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 184.502 692.2505 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 184.502 681.0392 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 246.8642 692.2505 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 246.8642 681.0392 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 309.2264 692.2505 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 309.2264 681.0392 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 371.5886 692.2505 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 371.5886 681.0392 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 433.9508 692.2505 cm 0 0 m 62.612 0 l S Q q 1 0 0 1 433.9508 681.0392 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 681.0392 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 680.7892 cm 0 0 m 79.62 0 l S Q q 1 0 0 1 42.7697 669.5779 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 122.1398 680.7892 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 122.1398 669.5779 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 184.502 680.7892 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 184.502 669.5779 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 246.8642 680.7892 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 246.8642 669.5779 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 309.2264 680.7892 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 309.2264 669.5779 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 371.5886 680.7892 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 371.5886 669.5779 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 433.9508 680.7892 cm 0 0 m 62.612 0 l S Q q 1 0 0 1 433.9508 669.5779 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 669.5779 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 669.3279 cm 0 0 m 79.62 0 l S Q q 1 0 0 1 42.7697 658.1166 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 122.1398 669.3279 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 122.1398 658.1166 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 184.502 669.3279 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 184.502 658.1166 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 246.8642 669.3279 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 246.8642 658.1166 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 309.2264 669.3279 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 309.2264 658.1166 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 371.5886 669.3279 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 371.5886 658.1166 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 433.9508 669.3279 cm 0 0 m 62.612 0 l S Q q 1 0 0 1 433.9508 658.1166 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 658.1166 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 657.8666 cm 0 0 m 79.62 0 l S Q q 1 0 0 1 42.7697 646.6553 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 122.1398 657.8666 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 122.1398 646.6553 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 184.502 657.8666 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 184.502 646.6553 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 246.8642 657.8666 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 246.8642 646.6553 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 309.2264 657.8666 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 309.2264 646.6553 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 371.5886 657.8666 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 371.5886 646.6553 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 433.9508 657.8666 cm 0 0 m 62.612 0 l S Q q 1 0 0 1 433.9508 646.6553 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 646.6553 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 646.4053 cm 0 0 m 79.62 0 l S Q q 1 0 0 1 42.7697 635.194 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 122.1398 646.4053 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 122.1398 635.194 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 184.502 646.4053 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 184.502 635.194 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 246.8642 646.4053 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 246.8642 635.194 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 309.2264 646.4053 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 309.2264 635.194 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 371.5886 646.4053 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 371.5886 635.194 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 433.9508 646.4053 cm 0 0 m 62.612 0 l S Q q 1 0 0 1 433.9508 635.194 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 635.194 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 634.944 cm 0 0 m 79.62 0 l S Q q 1 0 0 1 122.1398 634.944 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 184.502 634.944 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 246.8642 634.944 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 309.2264 634.944 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 371.5886 634.944 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 433.9508 634.944 cm 0 0 m 62.612 0 l S Q BT /GS1 gs /T1_4 1 Tf 8 0 0 8 141.7211 706.5463 Tm (\255\006\r\240\b.)Tj 8.703 0 Td (SD)Tj 6.441 0 Td (\215\r\240\t\004\b\004)Tj 8.646 0 Td (\215\t\b.)Tj 7.628 0 Td (\215\004\220\217.)Tj 7.257 0 Td (\022\004\213\206\006\002\217)Tj /T1_1 1 Tf -50.688 -1.433 Td (Wexner \212\210)Tj 12.622 0 Td (13,1)Tj 8.045 0 Td (3,5)Tj 7.545 0 Td (13,5)Tj 8.045 0 Td (5,0)Tj 7.545 0 Td (20,0)Tj 7.795 0 Td (15,0)Tj -51.598 -1.433 Td (Wexner \215\210\221\214\213)Tj 12.872 0 Td (2,8)Tj 7.795 0 Td (2,9)Tj 7.795 0 Td (2,0)Tj 7.795 0 Td (0,0)Tj 7.795 0 Td (9,0)Tj 7.795 0 Td (9,0)Tj -51.848 -1.433 Td (PISQ-12 \212\210)Tj 12.622 0 Td (17,0)Tj 8.045 0 Td (6,8)Tj 7.545 0 Td (18,0)Tj 8.045 0 Td (5,0)Tj 7.545 0 Td (27,0)Tj 7.795 0 Td (22,0)Tj -51.598 -1.433 Td (PISQ-12 \215\210\221\214\213)Tj 12.872 0 Td (8,2)Tj 7.795 0 Td (3,5)Tj 7.795 0 Td (9,0)Tj 7.795 0 Td (2,0)Tj 7.545 0 Td (15,0)Tj 7.795 0 Td (13,0)Tj -51.598 -1.433 Td (FIQL \212\210)Tj 12.872 0 Td (1,9)Tj 7.795 0 Td (0,6)Tj 7.795 0 Td (1,9)Tj 7.795 0 Td (1,0)Tj 7.795 0 Td (3,0)Tj 7.795 0 Td (2,0)Tj -51.848 -1.433 Td (FIQL \215\210\221\214\213)Tj 12.872 0 Td (3,6)Tj 7.795 0 Td (0,5)Tj 7.795 0 Td (3,8)Tj 7.795 0 Td (2,8)Tj 7.795 0 Td (4,2)Tj 7.795 0 Td (1,4)Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\033\030\031\030\213\b)-20.9(\035\231\213\233\t \021\032)50(\b)42(\032\231\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj /T1_5 1 Tf 25 0 0 25 512.9518 56.0378 Tm (77)Tj ET endstream endobj 1810 0 obj <>stream Adobed     '$''''$25552;;;;;;;;;;   %%#(((((#,0000,7;;;7;;;;;;;;;;   %%#(((((#,0000,7;;;7;;;;;;;;;;   %%#(((((#,0000,7;;;7;;;;;;;;;;""   u!12A"3QqrBaR#Tb$%CDS &'()*456789:EFGHIJUVWXYZcdefghijstuvwxyzu!1AQaq"2rBRb#S4Ccs $%&'()*356789:DEFGHIJTUVWXYZdefghijtuvwxyz?VƵһrZwfz˺9GafWAd7@ !;?~aIJHu<%,n1_2rpX$$9xKZ|#Ac)pw$`\HZ଑nCTL*Z[!i1 U7w*!#-J{>ryJ+1&j BvJXВm Rُ.g9Ȣn"it0IYߴ?>309-6=brćÎW<ܴ4BM4yg0#i[t67Vi4KNAQM[PGO)*вSrVI4z|;p]} jB yܩ4![)*J±rEՃEҷxWȩ;uTҹO1[e:Տ[\qǛg~eJ>LuX>Eb l M~Q3BR2&g<GVc1`$,⽙W@;2Gdi, 5噅18$L)DsI.QSdRDHqnZm~$65l#Gy/o+*nَYaRBTM#Kv͜㙆MRJՅtPZaܬX]ѝX.xei;#Ǖu8ƕyT:ɜHr<( 7FՀ0.nB6QB_YHn%n\hm-S[+M[di;y_ yT͐N4q|2YUW1KHO-*;V+o'!1S4Diyneg} 6`G Ra+KVah)}Xʓ𻕖 j&n O O|8yVTGS3GxZCV Z-V0 N wܻpC b*eD.u 'hOLǍVw~Qm=WZ\aA}# QTҠ;cSix"ӮpQuDݸ*SцFxY /pf?9Lp@g,1 R pKnR*퐣D 1F-8aZ(%vZ=v=䟄\2pZvs$$$ǏnAXQ4W' =i.iYdUHmyq+f5 k9yɸ+l#Gn\LTX*%ʖTl yIJԱeFA19\4C:GE pMdoֳ #G0%aћ*\5Wͥus&IlĕmB:`eVCKHZi𺩤)lY+6RJB!U 0HxHvla5(1 VuiʏCtxL0ju vUǘHi˲<?Ro/Ǣ?E2t}Qf2ex\ܣ4$ Q#PRBR8A M:)ֻnVi.e^0I0HUN+~=!gvy"RºS@IIHX#lSj[Y9%m9.l?5TGh-dJC)c&YrPr "8kmKZTvc0fg*r2ӱă1睢Yi\fޙ4T3vEFN-0,&V= -,KY~|;yK/5)*O"ҚV9 m?p"]|K/~01YvN[r'r1%NX<zr9?(.oJJƺI \oWO-5)Anbԍ@ B "8 3%p2*Q !L<\sؙg}yc6vGCGTH\3 9 11i>U.hfcL#G xx%7ZS^c,̔q 7`{AQ@X% 4mc@H ^ǑN6 ߘ\X`Idrˈ8FbϕzDN2ZJA5,vPKJAI ?lp8<*%RВ/ZƁI{bk@ 554EYX@40#G,pJZY ) tbJJAbd<:yeHª:VTHc0w}.uMCQs!nnm7qnY^lhHᄥQ%b8\=2*@(&j9;7jG*nfIX4I"0K!Wă*'J.z9ddM["U};tt`;w;\'*T* d zSȚ^YD͘wGR (4G$I 4r7Rx2n܈浓'1mv$,DQspZU=%MM9!)P% vcNiajWrq?H#3H!cfiBJH=C:/!Zփn4+\j#l\,Mg:'$□$j>U*X;N08ͷ| mCZK nh< u:~>TîbsLrȳfJZ"rB+?pNɊhyfJVDzk bmeV*^ȟakohհt` oFt16dՁRyTs1rAVcduIB1) ;>ɧqR*S+Ȟ ZFص0Miy~:i:=o.֍g&K9I4RGXq9=|l@_# J镧2CGceCjc>EN:nZiiĦ{i2q;Bte3--H; cGq3Ҝ6ɖ 0ؤ)q\l-/V̉KB\M W5s-pm+ RwGM?\1XC w<Qv͕RP,dC8D-_fYo.S7k #k}n<@ǹ]q5h b }H"fY%JFIH812ˮDG+ xKe5 %?(B 37וWP#ZݦMOXqijg{2q !=^KO')2մQY 1T݉)%@ԧ 8< !)ŝXSy*_4pZr<4<ڊd+| lPEo#5ڮ 顎dIYG{%2},f NН YNELh18?!KL4(YW)7AW7B1`ֱrs^ dIYP$,ۘ*斡@7ǡeg: WyT:ҕOZ6edr>fBK98/&fbhZ+&:s\ycrU:.*kxҼhn-'0SCᓉNIh"JR@Cl0 z3@wAcB:Urn]21c\㛅&$lɶL{;RXyJX жJO8MCHH%,2B ^NKHq{bpy邕 ttzJJR $jUX6#mm̮qſȄe``GU?ps.. ~%JP }qgaҺȈ/uRz-<{lբWp@o2W2Pf^ThAD* MҢX1ү- R0>x+*)"0y/0fmȳX4{+)2+l\*/p+ISyO$+O4$fC㬤lX;̭1iWYtlosa*Ù4o)6iѯx [#jT A8)ISA!'r~.\͉ m3dL|hɪ])[O$^342ˢŹ/itqO-v؂z,%%rEq2qK*GV6O- U yҗttytǝuEe;M|)̘C )  GEkso#]ZȐotydTs t:ݧۙ1{4(82x4v@߸'*1#Z<2ӷ3hR>}NyZu6yǖ))au'U>&).9e[&;G2 jY/kW3N##V"^ `kX{b7_& cM2ZKWhtw9FTK*XJH=Qh#Ύ7A\Z#'E02rQ"d6 KBPAag#=Hv#3٢c mq֓:^*Rf.;gbC(7qZ ).l4A`G3yBrZ N6dݴg9{-:}'!ˢ:M6ԵCYILIŇI*){%!˝ZzS# *rǚ*yv+ :Z1s'AYR20Lv\3|'jEewGOG8PvBRtvNȴ̔>KH7 GTqeRJ#h\g*JG:bFiJq4r4/Jhi9E+c%RhV*+QT86-u,febtMĜBf"\F !S ImJ $(0wՎԄX 4rܺz,%IPc,.+Cʘ ZgL#d+R#;]^&.q0u{#K]cL̀sv?;ӆ 1)(Re GIOSaN`$ǿ'C\82-V90 ZrpL!\d'JÝKsx H%M椪)]{֡cl =d,J#[tlBs_#Au%.Zlx$ehK&Vi + B2tm $Ԟc(۳#_]f^z: Dž&ț2e p$&V ;}IRژƶj#d ș&nT2[sp׽7E/yն-(pQ *sT "ɒFd磓D;aa! 5reD>T=m|s\cь7tDH\ȞF8ڻ'"B3!mو4d pFcr}y.00XUgl- MtE89Hb FsfHU?qp#G)ܗ.r/M%εxfD;);;#V;M');+iMԪC|W3N7M Ej;MM]^:Sq.$DRH֍䜓=$Z>@Ӝhq+d`SOB*qqK%.ǀG#eNd0r#Xd[6s0(K3.ZIK3 <'عAciKQJZn W]'jG CE}E+d[$ x[VNDL20rQ%ēR&-ȘYx#sQ\ lPؼxZC@KQ@p_V pXh*Hdu񫛣 ͏yemKlDʛJ!c_-cd#tqUxjg&JTǗ5D?CJZZR-$,s6k5h<a@F8qkYգ= |g1 KAvGP! M G8ER8 .oU-$@8itv;H\sfy1ܠCƎf6by).@1W/a0l=%*ud6Z+@Ma2#K즊0zOg<=ء芟(0 KQ ^8S yN ^#Ra'<$)q} YwΘϢn'9Xg Rc<};DŅIAWX!#Ċ<DT $$Tw-ȊJ3l=z)VI^eRǜ; ;sKTɪBn}SK  Q%!YpZPMLr2gX^ģ6.#[͡fn%cO8iHiN7O榇GI}dCn\K%*:eЭy7#!Oy(do~"W* ^ )9$|F%XFD)SՍ3- ԋ[|:sE_UǛuEe;.#93H NA817>SlaI 0]i@-i^lP 8@9zdx< D0)sx^X۞;HR=-`N=%[ylG).B'好+@5$v y&J bU,aZǜzG3,%KKܠQ)͞PƤ;cRN-DL^ I;@.X%/U:I&y">EJ B//U y1q;SO^uJP8Ax8,,H6"hYQ(Ll1W*YB1r*Mؓ,S&SiI5ځ+B֌(cLΟ35ahw.lreKGGG8&R X Ý(gS horMTiILTo<5I%ZSr -H]i3 W Lݹ;A'e)e>PT\v4$?1`x$_$5u5$SG9WtSRAQR $p`/(y9@E#K<:;9B,N&m!I/vy:5tift"=TM%Lę%qs?N|xQfp sl"&MQ׋ԫfcV+=R|s 2t t?&I. Y 0'tv&V"B%뎫pPO.cl#lJQ5rHQbcZ4,E2t^ipp]GK1('R:|v.f,'tkP?A;2d8NlLT.C][^5ep!El"Q9H2W,r (8ZUpC7$6JĥI=-J6ֵR=".9/Jq0fIX4r`dɚh93%a mdēy,U~ +'P 6Hh6'kWޗE+x{w&VQ~AfK B&RHd)Q>JG+aVw(?jTmc\Tc\%9YgJ׀w3q4q핗]+UYGzh͘f\b`dߌp(F!v:%4 Et=Xph&`@ C@+Y2I!%O©!1ΝĐ镰MFߨhXnwB!s}nW U)m@/.ϐVI;i_ gP9h6p)Dy, /-Dd7lQ7kFe~tQ$-"2x{y U21, `f`Ǻ8bR(lyGMŤIɕ,4# d ޓ34NC$9evZZchby6:ZMCI*).qW]# 318P '앪A=S(\C/gʼ5(.ULbX#y9dycH S0(ZFgZ71%[l3^}vE/w/ &hDl,Hq7 rb[fk">%h+B&\bA!ENХ؉IEy)up$#% e*R+ IcVffb͎g.$ Kzm3G\7@S457;a!;- f]KZwhӠ83[if0WĨ %c']nb!hSb 1[B7=ʏ:Ǯ3V'q\v &f5GOjHϤkV;oRTN1\QZcVas`RML%{ G K$)IǙ35iR /#(`‡rb2yW ,.#wxhsjvf$6qC,'tuyS0 Be9DU#JSq i+6KFyH;XMp9A2RGX%TpVf̃EL:Buj[58yHd\{DF8sg[}ejSu$}iy^xB)jUj,pvtݢ$4As$/iI[R[^Nz)p]$z4bLZ>?aRT^00Shx(KAb97@)W4:"c f2A[ #*82F4tѣFԴy(2<[|Խ05Zښhѹ/8b܃KEK%C\s]tW)k#4)"w{㒬d K  u$fD3hvU5\s(\alUGGw=M3c[I`!#G(3H WU{<(=5[$6i) Rs{#S%KY3Fs[!U=`ю1{ tV]3 SP3`ǙG Xrk9[ԚwG/M6(FoU<1?}Ü?'IYxɳJ(|q 8\ R_|tܻ);'=%TVDYZ fXc$ ڭ@FMyyL,LZIQI6 {%SXrB@J4u9.j%f!!(zŒFް&ɵl$:J'x{*Dp0ɟo,rx)*Ze;34B恷BZ>wpG8nՍikq6Ui7*F%< 拤M`|p5cOϖBn+%chS Xe*lBR|ô^b͹k.۸c`44mcwٺ*e&!G^4aȕ9R~ Oؑ13P~0.<^ R"B4 ;cO%'Juqyz-z>ONYN!*HE+Gi&iá)(IںP'x$ޔ2_Í;aGV9%)L"V9@NrzI&( [V=(b34h$ MCS Qٸ軒6Y X.o ;ɺiklfaikt]$fq΅ 0HHr~//Y*RvvhW">qxqg,qӮF1)RӠ*j.IΎk&ZȞ-!HK[Ν/\,K x2XLb[\xKS@L igkc .ϒAePLsʦ! }0|-sbY"mLLśmLjA-AGA*IWnLtd."e3 Sp@h,ZŰ'%.M yNKrs9)MuT(:YqvXMD.H̃BM:'VLe;?U@B&Xbn20#jd)`z$ W,oK撺(6˒GRq[a6IcZ!D^G_XrL$e'L13 )ģjQ\}@5j̖AkH:CA|8dquH"q<'q}ie{ GfK):'cg *nc<6)%\ǣZo 9=J^ *`(805g˛%@pȷybH*x*bIBq h2j Ntj$9PTwtR T,MHRm|>󖎅ϒY*0^2`qպd5cYO1u5Lw/. 5s;$FC2l+ZTTfmF1szv9Ks+[K6XHԴh`qGeiPDgW&Κ,/qK2Qq;79+p"|kh| q Ĭ|h !s-9S' $6dJ&<ɤ5Re+"`11CG4y8Dsk$if5 oVhb1(cZemKpĀxZFS8[aXMUǚ (PeRTP=@Jw^=,A\ 3& / Ϧ7*b,62 ̗, ʏG9nwGbvd<`cI Bh\ǑrRJe(,p)4nJAL\I6,7j*a5Xv':CEIY99coYy'1[;]rAW*LSD,?}@Gg'XuNR j#༌f^*tų"

_6q`ƑHlL&De h%yu{k}nv)Tjq,|[UzqSZN<{2U,#8+$A#S+R*)ߥ0A茣! o-xD}5|ãGr&DZ<> by'9GZTaBR^\ǃ|#r.8}XV`7\䋺ByU7sÌV(jh&m IL: pꘔa!Yr;!X\ 3ܺYq (L4nTG^p陇؜v1c)i͋x'r̲f!Y$|z9ɫ 7FJ[SXh67t3UJ 4krB61~N3p+C-s4%Jdɜ=TidWA pmӒԽ67dsjCo2  ^dh <98*b%ˇE))ۘvFO1-U06š; }s89%ȨcvNԘ#|#+&_٤G9[7:J0d˚QG/%Q!2E!эެD[N9U%.{{y.s\uu,!ǗLg9+(i~^*/ B[ fve b`=' -ehucKIɪ\7%Y{Ajt  XaԈ*r8y%&=>|ǖ^PEKSḣ.4ғDTW>5d:(@u6 봺M쀐ê陠Br3`c iBH.ēHIٳG2i$ a"̜kvu]F5N!8u JkI鑍%dmrFREKvCb,}k&tN}ÜsS+i$,2snU͏o p8pW( \r1ul%*T7RRNq&A; {]!YUsk0tL,E A xGRpćdE"2LΚVRsJ(FEZ.dc>t=1B淥L;irbBS"X1ԓ.#/ ddo7@7" 2Ŗc;ɋ](A|إ*ٔ YFjsT*a')f ֋4uj S󒹆QJI6h^VfbaMuDt|[潮(w߼6WQVG;.J HH'Rы/=XTBY zѣ鸎FS*:nQdJF%7,cz9Hmی GRxbs0q!Ux >ly!`܁hj c$%H2ML4@bװL. hWnVLrngL'Jɳi7ipixm9FeyZ,Ggs:hr  YtNG(qs *bA|HmZ$s12Osɜ-#,R 2𸷋qə(3f^fqĢqiDH.3]2Bvg){E}hLP @):\"* ٠)p<+c-A ZAi#{[rtcG%H,T^Z6pd%Irb2e H AVGv.̎x!ݤ6E(F Ѡa8)4y,dQ${;[9Hq*"D]D<:δҚ_|+uԴ`kCm\iK6%h~T!d9:ERMbfI&^;xJ];JjikӳJFp.D:X1 )]`oԭAtӰHhX.&lnhJ%,t@.[Q$=H뎮LN,,.re%d)Ga75ai s# 9AerФKd0Tg0Ajս6P%5ؒ $v\#%\b.p*Nz N. uv֤n%u:wLpq.A\tȖ&XHUG 8|\hLThR0ҥ@qr&ģpk>H&i A*8i9$6H|;.w9VsTQ E|09V6;MQx Yu98{E4YXqJ19+hW3 *f.\x<<%IP"/܍+ Brlᖄ%­XZ,o* vy1I@i+e 3#4-IG@pE-ahp/m eSthcqn)~dZ4')7 2^)<~9m'=/ޒAJd3Nű2Ydlַ[f=!ML[m.q`3''%{4Ȃ7IeD!]Q#l6Ă ="ˁF%r̾l)!aEDLb2@. / 2RXFTC \"T3 Q,*S!r,; B x.UL$0 C1&<&5!nF` j[I:^T Fxf,+Ku[{0 Zo48.ʺ8N N 13't\=f;+LZ:\N;nZʶxa6C|n 9g5,9H%|Tvra}hhL؉hK,.NKRI8'*+~ew B:_ܢ xձ6KMhH JÙHVh",Mik}qsXMJ/'RQɊH0kx8rYb%V{A^*Jđcx!.X7G\RmΔEA8u8dpV4 >ԕ)-;$|fodre|.c>,˳R|]Cq̸#.T2+F/H6t,&b˥MUh/5@̈p;IBdFqWSiŇ8ֳZC1%r[' i,įX VRg`)Ia/k`1h'ۓ$ 7Nԍ)!#hUAvrJړ< c*); #9:jS Ţۙ\%ȋys@8;< ZR-1q8l.$]C{sCH!\Xw>h y |cV)ioDu*§~2R(MeG2dKVc0Ĭb1 8?ΪhRze`ZsXRzżmټD4ϾdfDƉ1ҧ"DcuXTmɆQɟɳgyJb.\&c CnRǙn B1 Vp:3w9U#lWF4Vv4M('ck#|`a I!-#Ӹ42 +fK aK7bzѣxyBzRK6%̤J&G' )!)HxSC \4ks\\Z7Jh=)'MvjMUL*I̱Fs˘kx5+RIlU՚H8il쁚!qE=W38Iahd6*|SAqWT;mJ; '&I LL-$Zc)_S*C6LI*E$GMU_ـ0փZ^ZXJlB,~XR9`٭0@)ʖ70)q/QDf^`}Fo;l 2b\ĂmlGX d "`J 1P*|spFJ GcQ|J#p: ]SH;^ɴu^9#ä;!Gp?3#!c#9}qMPp>~h>|$̜U?V.yPDcZJ{cv^8 .^p1/aWw.(4qLAF8䉉or;wpk\Qq)10?ZGY~ʇ ) ҎH1Z4qĢ S͇#PbN􎖤v8 ,uۿH7딥旴0$n$>6T8ɫjF%J; sb8hà!9V 1–M"P=埸\vYKZ4vyHM<ҥ%aLI&Z9$rT$W9B!楆Gd8ͷB pٚ7p-sZ4t$\·B9ܝ!*V h|.Tbd+/0َ d[t] ᕛb7{Qbico6r'Hdqs}O;v6HVz8H>ZΠ( Z;9XltX +D`FKe$>d(K,$wXbimEfuZ`:tiNb81[)X.(rs1gh"dv'Xg>B07RQ [#.gSnT&8g@VŹK/ d`O#-[t" p:w6ڮ{s,S:R)v\ieY k/o%;'%U;sQX"- l>NwOO+;Ƥ#D0fm$ʚ e Y+adf#W'KJN`rRU(A~5D2d1F b k3ƢFxj,1I<)J쀑H(94Ѣ(F4h(cF"(h/x(ѣbepxe$MAG~ZJd+ ?e!^j^`h5&< \x-)4Ɩ 2]x/͎k")6Nc"LVPcio4ybD,R-$AU4|-5AsMX }.טvh }|.#]1zɛz dҌhýehX͛y,(G2d"9#*ţ?&YnzV8cF̩CyjaS5q̲Y}1sXMJw饫f :Ǜ 3n"*P"zىvԈhB34~P7AR}LFd_WZcF H|eҚBÎpI﮳|x˞Ee`m|<(Խh@hba$!j%k&s*#):ٶ+Kd?JV[7#y.ѢqÀDq@0GT4U_9J:@Ĕ`oRm*%|85ZrULv $ h#ŧfGsI2yv1tJ*6RkO(LP_ےJ5Q0|VY3948s/ʸyB,(TG!2F510kWxܫ\R9R!E#A{\0EXkAs1ᡋŮvF$4ȩsIʙ\RfX:t,^ d:0XukX43;ԶWTW%ƍY%5ZlpG@N+lN\&T(PfniaԠ˙N\f墅QB=K`K)Hx(ѣF(F3ƈ-4kFxW- Ȉͮu~ftWFVLuH3cO3A^dD.&z-3$Э2CZ3=Q氲&.fPHQg!RHL Md7 >(N^j-Ue6|-Y`LM "R Os1HYLaGh$@#Sg ed|ҺW<;˶Rn$ 4N;AĥN- e2o) I+1͑.D2RvR-yLϲ7EG+&s% g@3\jIÄ":1s*U7]aSNHTl;h=%prR89;晪7kGo+Іt9t-w 1x_\_#3tZ:o)LhfϼG p|BT `BTDc6 l 6} I;AQQEER.!V x/aqE1JI9!C(F^q;]\]L#DԦΑjGJDQE#H*6O V*Eq, csu@i-Pzskxˆl2 WKbHLi4͵ 57QšK$PDzTH% [kJ(skTk0wkn-$KK,SDPis Ǝ:@ bTCw$` ~ٞ:9@sT)L{%hW;  Ikà)%5$Gu|M&.ZAS89gtfO:ƄQ $cr' )Q1mxMt屮KP"hbVj7O r{'kOVp o\NQ>ro'&@n1>Z@?80GOm 9C)T/Դh93/YPTz:;7 tpiĦilRs%DϨI\9~ig:}Jo#C#+3b@9JO:aFNO~*f;<)rzҩYpҏaKaR\nc|'3&X%/[@7G5.3nF.b.1 j ,uK}LLl.-.mA 33Ggc#9}q"h>h>'q߄}>!P\ZBM1I''h17j™IH}9/EZ4L%@1pxquEF0BTzB+pA]ysIXE S `^r._3vvؤK($T^ S[:^W!6AGYLFq,-TYAԇ+Kb$$}Ԫ$1#Gg\wStAdo$qR,iDaph3ՑDgr"a- v 7XX8=Zua"bܥ%Il"PXĞCC#lT3[Մr)sH&|W\xX6rai);sP8U;DQc3uGL0Gb0nX"%D:wC0'dWI1a1JlBG,b@L{ߋ@Gg S]qser:1ldQڞO;b(rpȆ2dd VdIR `ŵcEK;P*hN3EGg c',$ǩ&fNʐ\ j(I0cC! 3R=iH 3 DQE =b(Ff*"(hwkx|EQhщGWQь`< ^QJ4"{ [t)t{X"frypfb) ❚Xv -c,LLfƫZW9B h)%~/6o?7Nʈe%$Ƚ21K,v'E,$$(%$ˑ)-.RRWĊ]\Z4Qĝ"(hՅ!b(F#m6Mgcc#9}q|ãGrUC'?.;Gc 4lwxO&\]~\Tǫ}H}9I;!(FHԌ"(hԍH(FF&F QEA-e !vZQDcAqю&X5.Q GN.)Gi@XrLqe  GAh(K¢Ǝ48 EH¦ZF]C8<qԍqR ȃ:9iJQQ ^c9I;َ̔ h7fM'SR0,nDړyb lMQs61qU,یG<fk{\<8 [l7p+,kGIǫ B6v .ZT\gxry𶤵 5]WG02J^vGmr<.I %ALu\+c05#LmL\칩@mW"IX J516hdz.S+iegJks<]G3n\Xz"tS-Jl0+e ,gF"BQxNʆVh\O#'`hB91<[rS–hÉUhY 682+HK;8yCk} vf%͟#hvW u,"<1\{(s(k9xl2e!"94 #.hh𱣊.h0D+ƈѣ.ѡ+x(ѡ0#Qu/!ssFXR"*$&,JJBJtJC4Un/1A 6)4I0Ipbmed_w+r I 2ȹI*x a9c Y(թHHP(8>UʓY3&LB$lNɫ5xl"Qgiy:]}r]j6U+&8d'V"(r"(TVQD#C9TwS "(-=bKJA(q2 ≮?ao3hDǑOGN"1갟~rxi$ k’0rC퍶QEE6/ڍEZ4QdmۍEZ4Shi@f"(hӊAH>PE n gmˊ"#B/d㈤(1Q{ĶR+(ѣwдQ=4T&ef=qCmDveBaIŘSIK^4t?i~hH:*˖BhS6P\- Tt11<wK@Ḛ5 m#末/*aS)pܶlKĠfcc0&bʶ< ̴R4 QpvmVg6蔸aFtX@ڐŌr&|9)RvR9iIpH0ItkVpR yW8'dc2| cRЮx; Y= ]&IE]AZ5yU7T h"u:Dp` |\ziV30KQ`@#t5HwK=M3\KqѩS -)D28C+ y#xBMrrg*LÐ}G?T6,PftJ*l16>5Z_@$n-s rpJr^7H$(]1@fr?+/4Vy 0LFEJ)=X%8'%􈢊!4+ƈ-Ƅx4- j@}Ѩb(1hS(hbD"HXR\D]c9i#0W1J%8&deRjZT/h5zB:tØI#H{7%a$aֵ@AZRH OEذΰJ~1WxU "~Y\⨗\z\4݄%%;(H9"XKr, QExUA(ޚE)!BЩZ 툥Qa2,)] G-Ėu-;kQDcG;{^D] m#l R]GpO3?/jjQ~GU3?"#N"1각AL?6:$91Vo"(hNm0 #È(hB Ǫ2uE1&Fq$񈸺Ѣ A E;b(FCP }1nR#%jѻaM"(FaN0/H,(hKBLBT "o)m .#k,1^ uEZ4MI9B-m^egc#9}q|ãGrE^描#G$>9']>/G#8=C}Ҟh Kj@a|ӞqLj8F/AtOp=x4s>ZLnzgW'1z }7. }7-,ij1ٟ-]4bDGo]E{Io[Y0csGF~i! Khh KjOAOpE3 "ϖa#F/AOpAOpE3 !ٟ-]7;3嫴F^hh Jz }7-,ij1ٟ-]4bDGo]DGo[Y0cs>ZL$h6Pt+H}C}آϔ_=4d'ET=g>kQgHmj{csGƌ~i! Jz7-,i/_Wi^C#E{Io[Y0_Wi/ 17.X}C}֢Q06l,h^Pt;hC}Ԣc0 c92nh7#4TdXJs^hћ4^ :0륄t4 bG\,h6? Khh KjFa?;3嫴f|vh6Pt'8}C}ڢNvgWij18ыm>OAOpE3 !ٟ-]7;3嫴F^hh Jz }7-,if|vϖ 1z }7)6Pta?;3嫴f|vHыm>OAOpE3 !ٟ-]7;3嫴F^hh Jz }7-,ij1ٟ-]4bDGoS]>mQgH~vgWiLj18ыm>OAOpE3 "ϖa#F/AtOp=>H=3bq'8}C}Ҟhh KjZLvgWiƌ *XcAdaՐAR99\@e7\!IMc #O\>B&)s b{/zT_6!IM!IMclG#G^#缏}%EobޡObޡf1|4}oy?OXߎ{/zT_6!IM!IMclG#G^#缏}%EobޡObޡf1|4}oy?OXߎ{/zT_6!IM!IMclG#G^#缏}%EobޡObޡf1|4}oy?OXߎ{/zT_6!IM!IMclG#G^#缏}%EobޡObޡf1|4}oy?OXߎ{/zT_6!IM!IMclG#G^#眑}%EobޡObޡf1|4}s9#b?OXr8^ =hTO{-:c{MGlq1HƋ?h#!NFjIr7i$pc!.qqhyS"Ae-):gKM @Əb>|KTKuA1}|??Q_;ךH4o𹮽R"yv3۞8wqFF-x#ml\OI (H [fHBĆ(O|/|rzK8gmvF4\%P9t=x2Bk\p$G)R5ϼktbޡ;Cmh~#(:fOP1Q0^#mCޒ?׫=M(x?: }8@|k8dp@b]lG#G=䏗=?cD6b:y)A `@ޑ5ͽz{Sz=z{SzX==?c~9#G+IQ|؇%7[om3V @Z5H==?c|/?)TL'!e\₪fO&B&Z壊y♳=^K!6g4 +$%FZfy;W1ˎ''}}:tSc# \R HJ PXVʔ *1\ ek|ny/kda {76ڊ{X[|j4t'BBGdbt%cA &%r8AkHb-DIJ *R-W$`@dqlD1P3sX]|KQդ]jˉƊL%)ࢯpY:#V%i8GR> rjH!ގۙhe<dOxk\G.jpEmEDc rpBj^#r *o?n\Ff?)[312P5 =TLTZz4NMV,eJBiv JdZK"RuNa\W#C֐uq?jYTDnKH=/%$jO)c-E*0<܎ΰvթ/& mՋ]5IU1,χ{UԺDWR{`l5G . a;6e*Y/0%4O,W:WxJ&]xt3)%su -ͨb=Ѷ>ձF/?y_+:R0r$P0涃uo/"s,h-M7ݪ[?-]捰~R_4u/}Á%V)?q`f4hdlnSO/s |ni xYCMoQ~Z74UzAVyA8w/N൲X/ʉP+M%%4(qZdcC[ MqDLjפJ2n'/&~? cJ[$m #9!Q)  G[y8U~)diOa9JK*d G"4iKHS/*jg +{b7j,2](H:c$Y u#0b9X^N.@[m i v*4w򸢉HvA"(ѣF-4hѢ(@4h(cF"(hѣF-4hѢ(F4h(ѣF"(hѣF1h6osi^kl?Gk 6mmcy9%x%*dkyM;8HF0`?›僤>hkIVWbbQFroW܎:|_ɿ\grF-/spL⁋h5sO&vQL%u )Fi%'u#ɉI+,mK4RshH b NAo HFvGQBX nqp/|N7yq_U|_U 6*N1;r^MGXɸlR֒XX\P5ZO!8iK"V ܨ1TF$b"8IXtF!AAq;Hm+( siB5Лu TM1}#;Joބ}>q?3@O&DB>ɶQ;K2Kcw߬boOG T_ep>jx8obHHd8ϾA-ِ%J-+ \W\cRҕ\$(^:ߴ bLJ*KAc";8p)b%AUOc%iiX+Q#[+LMXT=MZ|21Xr%mO8 laR1$LL(8)9p-v#0g > vt o9/V1Z)epx b EׯH%. q0E3'Exc`z v1J'’*r`@ě&V2Da*9U s(֢xhFAEZhѣDQE4hQEF4EQhѣFEZ4hѣDQE4hQEF4EQhѣFEZ4hѣDQE4h\RhѣA:; GTPg4Mg27ۚ}X9hXѕJrhcvՈsTiQYZ%KW;ir)B~0클5ȍO,O/ JOG6l -M$ ܐH&=\~"AeL@:`*G24tG$K0>r9c! 'ZmUBΜ]1~O XS{:o.IjlN;DG  %j-ކD5Zm=>|$R{D l=,h]Xrv'hiq`HJ)"l$c2ScѣZvhX˭-`恜m{cƏ<9C1ΛقMTJ2 OȢR?؍з]%-+%b|#GE2G*RNIIj^*pʘS|tjSEc5ș=OV㡫e'hh` 8FJ8?m9IiЪ2TdCr[= t~97G K7_bH`' *Zò{5FSSr+[O G6V mdJ¢UIZ%${^$u펇LġM2TA4e GG-*>DqXd,lp4Nۇdf|Al$q ݡ6&7*q}5nЛu y%E=")Aٝ$H$?WR\KΒ)R'd쮀c})zp7})zO&]w!YmN#? tO.='}}!߄pE;W1 7橎#*+QE!㲍4EQhѣF$|fQ!F˵@Pbh`5ad⓳5Z(R5kG[Da$m+#bLxsVPҹlr~B狯€ KݦǜdT̵l~qay0QO'b 0⊖ IJ~Qhy]8j-*S=SNt I*,bFXQ2Z[xK _ ![+h[49IA][C ;5;\*pwyg!.ni3irI*A;_چ'eM0KQQԝEC|Krvnk7GXQ[GEcG׀I%ab,dyηU7)=I>fGPbk lXI$9^Y+ 1է&[%Izhki]:6vCfH5l7 ou# xFIv KZ҉r1KR@s@A6g FHPu$\)iα[ΠDQ #b~:R}89G[( $N/(~+-I$1MipZ4 Gق\>Y*w49Ş>nl:r+{)I m̞!=PrtU}^A-P|]F!=c]&#!ONFks#/)__/_ 6wf,2\0h8v!)6OlP$  ^L)Ѹ*[znaezxw:H!V %,9Rq~ۓcp x*bcVqGؼu[?lK( ,puWH MOircq3n3`n(9 =sf`Gd5@PLadu1c2!ܐ֏p@ؑ>K*(|D<>H)ڌ#eU:ba(p!cANJ6H%.Ihϕ eqI:$DZP!XIG$KJ@RH p0s\) %b* 0Jh-[Bh8Xheq5fR^Jzy*Rj^^ #V;uZ4LK 8C;F-f&,!3GZ^S|tj1?eV& } b5N;ܴukj/QEGm4h(ѣ4h4EZ4+EZ4 tZ8Maʜ_ad [&f&cF:'淍~?}#;Joބz'淍~?}#;JoބO&DB>IQ&y>꣌<+S~{Y\0ߚ;بET4hQ[x$t{FKT:>\'JeAY[ޛ'1Hq6 %\ť01eIVyNXJf8p.@*XgQ-K HW;؞Ps bH =^tbDh YI+?--;$ *93 ; EbF7hycݭm?+ۘpV,혲_9~z<½#P ΦJHuJDH 'OZYB  Rj9йu*C?IL41@.6_M|9,4숢-j- C=o1+64DQE9 5 jVݑ *.-A5"(ŭVQEF  BѡHjI6tKѢEGth!T>h.e@ \DɷhBCVLs BKZr@/ffbu L#Vyv p1>y %)8[`GE@N!oU&X9z +] F z*'2r1ؑQE$2j+i&#"3R.- pvEQhђ"EZ4fэ..hѠ<EZ4hѣDL)X:Cf0`?1>b L4tojwt\@63 R+걅/Jʲ"DQE0]hЪX 9H06SEZ4mQAfZ8MaN/{bn}Sezkщ˱n[p{\y/%7B=f -j8_ɶQ;&y>꣌<+S~{Y\0ߚ;بET4h7woL s^pǰxh},'kw#ɣ0;F6;0xuͺdؕ폛2l.bG913 *(i|/eT69J)H؞)\qMX*GCvF{ zۦtporhDsb$˖Rf) J_d@si,!H)$hU1*Hjplws+ 2TKF*;%j{QBe|t8NTIW0C) bXxT4ɨ#vV2ڰ"dV[Xn/JC9WTyoU3q>[1hjh|(BYJ ,rZe`\ WCV) ʚt YT9hs~FfE.-9+ #tKl|hb..-*R$ "F zh/ 6(Ѣ>pot..Bh؛r Z:a]hŹZ8gRxM muEB9HRtd99&Z 'qxfگd H ptit[x=oȻB{ՍgҴhbWd2@-lHSVOTsl]OĭRV6X e,aFZeA3PVC˜ NJ5E$d]L#2L"2{Lg"W:02h7UKFK&w8|Ŗ, )vS|Ս\z" Z+gdX.h%K t %TMo$!D|8VR-u~VURDm -;Jl)fkaדWmxFY( LT]$q-Ф`"(h,&X(hv7H}֗&4,!3GZ'OY_Չd#~k\Uw#15N;EW[/WH(ht@(ѡcuA"Edz1t*q}5nЛu 8MNMF'.WSֱok)?3G~kxڎk%?3@O&DB>ɶQ;K2Kcw߬boOG T_ep>~jx8obe<&xi 2<49څZDP=Tk$-a\cLbԥ-rTNvǦ`BBX1H(:P¥* 0s&åsIN}qV`\xTΥ>JcZZ ~ud"6#[7+ ѣ!U{`<qw z>* } .u!rWj )8isRF@Fy.<7*XDOċ14ݫvX)@ Amc @WndwoUHϡV)#% PZH%bfN'jSO6h0PB@MthQ'`,\Z4vg_*HZt]b..h։mk|rYvhu%ªh$BwFG Hα& qStL6pNFdr'īkoVmKF"K &:A$xS,5J),k4 W!k@w:3#q귁hѓ( ̙5rQ+?!:\K`gLC) zˡ['q"ׁm](`Ѣq M)d|V}QΑ1aNTˑDmL &`stNѴL/d)v $s)[` bQ>j s5ڥ8 iȸcr*ͭ#緵tDfbg *QJY J(jTr{G%<!b0XeU=~sg5G.\89'-1ap(%'*id;b Lߨ GKֹ;Gw6/[ڮ3\*(9X/ -)MD:mWzDQEɶQ;&y>꣌<+S~{Y\0ߚ;بikx6r'2$6ap#]#%!T+**R JF9L2p$9SHt`u\do dER ٓ=ڀ$.:="N@# CyԬ$ ?l+ǣ=)7;=*kLЕ nrEn79) )D7+q=%dz[WԉiiXV {oOlX6#+Ζ%QC~QlMBR]zI#¯6VUp4Bf*\@IbŇ#3\s(p= }"2ϗJS-$_Eer‚̥%.-1ēA`iHȥ\}9#ha4ĕ (Ф T:MZvQ,;+$LFdH1գEF#(6 pP;"T" X@-*4!䤀H@&GsT9*+]]-ֆFȈ {ND5-RxF$֊ [剺< $aC1>Uu$|ٔ~t`ZQ0hBa)RŁ^?dvP[D摭T 'jݡ6&796WM_z15wO ǔS~#_o,/ޗS~g`? MЀO&DB>ɶQ;&y>꣌<+S~{Y\0ߚ;ب*G9chp7 M.S1/a jOjQI6XNe0쎢tѰ(*f#f# +$0JZ:m-dJPVr-1c7%v*haa|cvYXGvnsG|%C^=Zu/-S7܆':bTD$Kw`7GgãNU*j,ݑ<+ah(%c펼`as콷|hs)0쾼 I_9z\L~f+GQԔ,m Mpմw+y2ʖJG.b#a1!/(LG*ʟ,KM-ɶQ;&y>꣌<+S~{Y\0T@$;SѰy(`;7Cu0HB9C4R<*b31BDGlp'bp@eRDuSq2yF~RWQb c5 -ۢ@mSZtN"I$N5s-hxZXp"# >EL.\6o!@:r娫P sW2y&JT3*^odKb)-z jW66I3ִ뻲Kb5qֵܴT26P:%׾ѣRpQ(JztCD%yJp6ZZ)4{!lj.hdM&MRLB~ .`(;rI$ylɤk 6X]V{-zBFQbTG[.x|1E#Ѷ֍RO)BU,HPNj'u :QL6vBTl)pfn#1XW7&L\vv s?*S̚ -a[׳e|YnҬE`N{+#}-p j$nueL#9n_9z\ nqZڨrPp),Pb>HWFdŭTJo,!(] +3ܘ ;d`=x@kʻ 4湬hIkT E0b$}a㎜Dlׯf);'@R5^䕡 J+e*ĻTݔZl6vOi8uE!d%2 ht6@Fv7 4s -2 ĤbH$0.Vl҈͡@Տ9iv~Qq9:[B\7J7u5h$D{*Vo@ ʗ-kpUv}kK(< 5\-p69q5 kAT1K=- OjR6Ԏ)`AGli,,3nWCEZDqUa%@#ksh4(L'+!\NtIQV:\(͛,/lv;"bBJohow\x 4R`|l2E\$ݽ Fxq)( *R{/4-I^pHmnJ 1Vhnt aZ:c9g nk#}hQ,Rx,JR։ %;Η,>.} <$8kYcG;'ɐԜ㐒NM3i2*,T,mdpZ4r) 1N53uBb7^8-$e2]hu)I-bm})ͣ TÒ󺎳qZ4^ZÂ٣)$QTA ;E9PsP%7 ҢѢr9KڰWfV1>5#-98\+T_%)YV.H% d׮9\GDMϮ8yG(7 UCFxl)VvZI}Q9H&$ 'jݡ6&7_8hMNMF'.Wތr<X ,+\y_%7B=W'9NX_.QUcV$h|tch"ZH G7$,ZʆKF2z K@zA>7p9FSɵO$n=ϓ4TEa4܃n^ʰiCe+"uCMŠZG_0mBw:q'i"paA܌ԫci'M o٬@ސfa9[3eG` M)t Z\(&a-)0-憏">s Ac?TF !,R +\uͰD<#^-S@kWۍkXD $N֍SR9Ǚ-k(,(:rҵ$$8K78`%J#Iv<#;&[䣸`${ FO l9hħke֏`-R!J4,BQITA=l<({m:{TD9I5l#/2+wGQ<'@Pakemc2Й|3a!DTz~NLxOS+7%;u|#,-h4L֎:ed|XzɣuDt@שR<'?j8bD| 5jN:n>ZeJG0b%OPtlGX/|Į@BH>sT44kVC-5KE 80H5,4Y/؁TY5E=4${׿Z4pLD z9|&ϛ"FZS,"İg6]KvR=㑍L82T! n=TѱNќX,J 58׷0[NpRFi ^wnInqVcM .9;ւW丕 _f+AF>1Iry`i$sۘ`I1ik6BPl"䡒)][K% xmn7)&Me2GZ̸D$_'T)Bl#ZEjJA!t!g͌vl*fbe7RNM ?!rAA>GE©J04C0.#[ܤWNW cT6M2Ph^c.Q!ږzJoQ\.ϢEKDs6_$) QXx3g ) w)/ Q4b F0! el׶ *'\ш[+I+'{p{EWNSԸqk'WS9<6SGyhS(kb%ВHI`b -(p4qeʗ*g6wdtlbs.CX Vp{ +!'s9ɝ2w6JB%5ԝIVKu+dvkk2JZn:J-FJRzP&-@tOH T8n@nKoshYba%m)r$Ф =D>:sָS @|-aB~d$Ẍ!JV/u@9.p0`heԼ,j7\@6/.Z93iskZw w GQQ1%baBX쉌%6dNRXS:\ms\LNԶP/l+\7Qb.Vu\Vϔ('aŠI%ETHf9eZo nsĪn F8:I/bE%)< xRHq8)*PXۗ_6pTJѣ\ad,!p&bΕ-%P)8QBv Ϝ7;DDR[!HԞqsҚ\ws0f(Hm>'qrĆ\Bx6ohö-dX8)gGDn6yUW+ $k$tzH0 eI!@Z 8^`eς'P9OK 1y2)]*0@h4_V?8I3]*C:Sf {!v[@#0Q0$$8;:rY)$/HQttBV1 W*)"F:'4H7;H,CXgoF EXYDdjI)81o/b(KIJÂ2M;"j&IeGLҐpbyDвPѣFk(|Ƌ^K#ҕ4!24ji:έۋM.DI9l:s3AHlv?'e usZ^#grdH@xZXYpᗉr8vMnu;myeKFxhyABmcaeE3x<,D9'g'6Ѿg(ϩ.a؝|a 0W4%[6;]#7b=:0J1s&Qh@E6H ˓G2nPQ e; AbqJ9Kխ*p)]$g 8[knXsxݹ^ʉ8Fel C;w9<>%|5ބ?T{< KbT-g#Rί"Un8ʳ9kDJ^;-$Ed [&fF詣cňOpճBlMo*rlMz19v>=&!2c6Ga=%ǖS~#r2V?si ait=?3@M&O|̷ d[ rmA5-d&^_Tqtz]Ǔep>56yKR%NL|Ԯ{%KR%lQ_)ssy6GÇΰp'.5KԒvn.U4$5 ȱȴ|R%@)̀6uǖAJ5?S{:] Q-+=vX~5|!Ӵ62fbmJcIjj6X/rIAh"LrOpc1ZI5*95b椮jT̔N'N4&zs1LN9Cie(L(G4 4l8L-s0B,.M mURc4<&?3N_ޗ +]U6q$lHB^:\vRb^pw!]zQ];mCޕm _ou[$iȁűn{xI x98fm j Ld푴+֢;UGMQT g VEY|8\!~tL1]dKn5,-/uZƇ5"1H^\/yLɌnfó@Aͩo"~/8! uk-9ɟ E,Y9[J3 ,LBM17ʂ }m|$`eSkGyDõ7Qtv\J⩙zIäTVG?Tm,c'lи)7[/]-A +FxI PV,QerL }qXQ.Lesa$yK uH$ĥn(?a0&j1 KKs1ޯ9D \C)fY؜$Qw8bqhp}0ṞcH'e`:hpuK.[ f(p%v쒥1f}h#xp(b9*&Ar,a1@ + aԂU お3 9eեXim W*Ƶ{| blFuG;X-:i HLĔb8g)(y`Cw2qҋKlLqbsSAT1C-\9MiH F4.aeq븝@T=CZeMLpؼjRdr҂8 ?I7.*Jv[BȔ%,QFHTNb,Y H!'S*jg-HVZ:R<g~b98>Q IeKK8w Gk9VY2Y +LGX3 "A><-SeOD|AiЛu 9$G,-bn}Sezkщ˱ 2X 3'  iT~g`? MЏGȲV$a \y߾%7BO&Nb;,]kFi$e6 CPwo+qQ]wL{NL||?PA&>~i*=X H Tݝ*bi펯X!zB J2I&_Hֺ X[ɠ3=8*+[ auac-^aBh}rcFT$H B-G? Y,˷8ع2UI 6r\ɚ{ he mۻdC,vxG91K"um\5UhL#9-;ǤRTTԧIeߪ;S'&%%!(-*cf뎷 #1j6CBCF2i&r̚]H4wc gsJS7hk/ Åw]Pȃ)7U֍=\Ɉ3Fb6mLN1J2sK C9rL' mᏬjKKi^T/ "<(7w&D\8Xs ROz c1^}s fPsQX/+ SDаҒ%SH[A\qfdnqk$ Y#P֫cq[+a*^: Jo1; N 0 6U12^ƶ Bԩ!#a#gxw͵ݯyZ4qfl%_m4E5xDqXdɰƹ)}nTTHRD.j`mXǑ&ah1 $%⹼rp); }PkR(lcNg5TRQQh7sv}cZwƵD1.hB-5I)dP7"P:$T*)#B.j// FwWC$Q[V܃IN.a̴f21۠"qƛ*dɅ)l{ X;-;7iOHQPpL9cUFi[m9 9ܛ]tM%9њ>ly:jP&-$[A˕y9Gd$%(JEuN hM2|Yq67;+ |n":? Z>mêZԐAɫ;RK%%)*Rl#ث rf-RR18){Í=VpeQHͧ b;]Z4pe,0H!ce ;fT|&8 DqT$^ +Y3]ua՝MLƪc|ȣ⣍Ɯ`-:W%Or=¶R*z;C㳛ܨ-40gk90W2b3뫥@E#cwN>%GQ?R%!;$Eb~ Rаt&6㖯eFt':{(|ݎ7!c_{wEȴ:Ghy̎Z4u> @@ϖ6~RJ5e˘h)>$rO,M*3RK [FgM!y Ո ♄sO\7$wbc\G9nGaRJ UWhuO'Veh#8N{}Xv?Phf!c0]0+gGJ6#hcO,Mwִh奈6f #ғ`d\8$);0XvG=0PYOd?6ӛqfQzqk%sPY\"}ѣܝpU,9'O/p]Ǡ%R= :Ѳd.]dF &?;y05!a^oϳa,ϼy47F3D vW_n #IJc(m[C"GAy9ܫLLSE<2xRe ЗCi5[@ ]dTǚ3ҹWLiR"J V) d;;_r'SKu~|da\uL7{ˉuگ06R;6qG*N{#''8T(&_MH ahJ 7tgxMD.hraBZC7lqeb*0`%2 ~5Nҙ˒]i|7׸c-^Na.żJ7TVUJƛ /J%JU <cG."1)RIHce]|)5B8ȼxI(Jm 7HCIsn>sb0̶yT#6x c42 r`_!k$iTm2d| ^;5s)2GhGp|j Zw+0䱈I=xP HI`ǩ 0@K8sd8" i{ݓOJG˥HQqD<|+W6&jŔ>'ëjLKQ HDm-0Ex[pZ4&f?N/{bn}SezkфcFWϕ=y-Jb#\k {.Y8&-4b1RJQ JL(`` ; xŌ5U:V"tśT~h<~ oio|rFu;sSEW%k#ѐÁ髫EE$t;2v1TBRt9܌OYPa#VXG I8y[ m!H%DSVe%<7"(ot4Z6B,rEŨ+R }M8Ti =X[~H8xњLjJcIVc9ťDdx )@|2$KJXdʪS6Gm;WE1<7pqi>D->j~HTIIz44P/ʊr܄t `fi~y FԽEGs j+Bvm.]_(+/F)b c۴htd10sp#a0]2eC@ 4EQhѣF;#:FJ2el6/:3~W|O=i>kxt]dh1JFNZ*4{ 0r̓m!D?qQEJB@H ,,=L OYDkƈ#4hѢEOpտBlMo+T 'jߡ6&796WM^DsQqGv߽?5oG ǏS~ O&NttGӼw3Ln<&l$ 6|_UtDZY\~#v' $W'}}>ms[$vߠbai-ߩXgs*GT.H=գ1ogP-sow ǜT UKx!TV֕@4\~^Z;9K KDp_JFsvC3o9sG8\_&I=;z"غ$ZL>gk 1{LxSmhI>_9/T3:Iy8L # 8R"ē-׎`=JM=Qd_umf@,VH:aa\Y JKl51GNJ~I[,s0kR4zTеd=X 8uBlَe,ʻdZ4lDՎL1S ]GO56q*I :9342% UxӾ 96XK2T1f]/pVUF|+*_4{W?3#ڨ/"gY_z y_D²#"(4hQEF4EQh1FEZ4hѣDQE4hQEƍ4EQhѣFEZ4hѣDQE4hQEƍ4EQhѣFEZ4hѣDQE4hQEF4EQh1FE4h(}y%7T?Nу +{roۈ?y#OA> |9S/x0\Vo#Dž%\ʼٖeQQEτ4h(ѣF 4k$?NE,!zp@ՍV3}v5#Ƕ?se;W-S880kr 7|e"ZI]Ê$KvV(T%U Ѕ/>a G8n2uFQs#4EQh1F?*8ș@-bn}X6)~[\MJEPg_U+ctkT&mK%<@"Gv߽߶߼"<H~O&L(=6K+e()w3K2Kcw߬c|/5dU"@ ];W1,Z9ɔk}AP]rLր5[ -3=z-YA̾A\K[Jc ؀-h1Vғ&JYsRfD l˖A)mD9J8)M&B%cgMa2ZBtvHvJY"4V*}`{CMU;^Xb,.E fl=g Fk@;&a=kE0v2ɉ)H.Bԣ4S NVy)48f~%4T"\{#,l$ҕUrM6d8l؛|y%zLՎ,Ն?E֍+,mtQ2[>TqS,K\yR!*>A%$칵TM^ଫE9_5b[ʳ'5g:QA)nO3𬯽i>Uadbe3p3wQEXhѣDQE4hQEƍ4EQhѣFEZ4hѣDQE4hQEF4EQhѣFEZ4hѣDQE4hQEƍ4EQhFEZ hѣDQE4hQEF4EGSy򾞗t蔕 Gwz/pW;N.$::[&)UO#Oȕ+! v:|+ ֶ'1sAcF "DRҎ}qȈ+@4h(P1DZ$إZ3Xn4hr¦#S%)H.Bօ&I!Ǚ|tzGK# 8\ ^IMMSKNq8Fv<ׁ6]_$Q^&z]1 d%,{Ĕl-~_ID͓6hTĵj= {#|W,.Jqim#dPchNL$|QEm4h(ѣF4VlR7ܹmЛu YK*rBlMo*R?2}J1/w+~s>}#;JoބzEoNgC~g`? MЀO&[h]h {|" eoѮ ,4L}GwG1y;W1~I #=TKe'GY\ljk+iXX0ۈ_M Zr9rDF<2^6/Jm຤4t HR\!C;)Z%r r9%5Y0=.L:6KJh{b I/j:Ɓ#à-KVE$<@7PV=hp)3ev Otqk8)%rRLr08Mps|()鰵)c$#=Vt- yKF68ݠdmD;jiLFUsx 6"I2/ Jis=wӖF! l-JhNq&Z'smȟ,=,R#RaPF. $R9OmF]3ty s_zI8{&C48$AB #zT*Dҕ%WChz|ߔK!ˆ:Lzkp%G Ls`t##&gWj $~fLd"|{#rߝɟbL${EQV4hѢ(A4h(ѣF"(ѣF-4hѢ(F4h(ѣF"(hѣF-4hѢ(A4h(#F"(ѣ8vNDQKbZ4ХhRGUOJ rT#.oĻKJѢ\ P}`k(E/ҁQ\:VEi n|hFwNIf.X:;"ISdIbSdl mWF EԞ it.фr5r0@sT~,!@U;ܱ9)"&tp#Gl~rJej`+r7R<46˫`ђlċ.eGM`G SE-4gg EPŗ$lyI#$ΝXfѣp BJ cSc̙hԨ?SGV|&HF}9dB짌 ,ζn=R|Xm_Y%XTdωQpaĩCe)N%EEc|2EJNXNEBH;N(A(6Y!At#/*\T=R I%t1P%z 4׀\`:^1O=UiRҏ9A$lsT@J89 1 kK\ʛBꜣ5 ʖ !!lX]G+8 #2g!篫2q&KxrJqȰ?0x9H(XM@_GXJVIV{ -XȢ8@ w겴7EV=h+w(RW-H$8(H ;ʝ Zl)#ЭEJxofyUBONG1'.QJA8(XR3' %螲V` ntMgZ }aGSq*3SeqhMYBqEEj(:fAp@\|&bi=P*H-R8,R- W:(LSw^*mz@'HEM OBgGrѣ(^bGuZ=Z_#h%`L3 D Ar+ 2NemK̚;ۖN_-`Ptt1tN)R~)Is(VgK='  8<)Q` 7}F ]a-v#ʴh% ~S&jGf匚h=QQDlL"]+ZFuYh-%Yq д|4Ips&XJG6cdGFaP)RTqɑ) JU9]e3(y @'h8 I&Knh| *aK_ Sٗ(nlǪ&\ xp -)!5| ĩIe,Kg#sb~Lt tQ%Η-dоaȕєTɨq;1.*3b~2 D:LC-M3%K "x3yAyH=QBGvL A ~&9W:S Y \HF,l]ѣOI&cgb}v*y5I TN.iQB[{yB%(P)\(>-X贴WVž -,L-<2&M L6fm*ڑxq>mFhB7}e-tƤ$]ӂ;5r4JXլre+647.z-TI)Lvl&L5QoT0VJR*5GluUJ;{,;3rGhb9%lPi]p[}qNLրF IDv\^ZLWkAܪZ-Z'.k铈T{dř!%_WkGi:nDХ|TDFlٴZPIo<' 4ԫ=˕bn}Y+=˖ 7Ya2}J1~gcd9GG?3G3 Qv {~g`? MЀO&G{G {M܌g۟؄:_Tqtz]Ǔep>23i! "VY\JvG.>vbP1Nj([X"8;wiэuL,qaw8*i#a]2p ůft,T(SlR ($0}Mo.HFjХʼn{c1^SMv)H/;S* ysⵖKk_ psG6b^ё7+FG)bJ*%cRWCprW<)X[` JX*jA!#6xۥ)+L5\Zek-C" E2 Q4s;Ԑ,We-Z4p9̝# K[guG^JR(je(Ep )2%f\Ғ lw5 x}Iv#Vs5֐/o>! becr X9}dzgaFLl)5#8eMIB\(IM5!.tl)i7`r*z LB~Qᨴ; v0㿭dsLε`h\@wӒ6Ӻ6fAw%)xOd|&d4T( #.`¤HSǯZIgAx"tX4:2 &r:&ju"bTXi@C189θ]@{Mx-7* &[V-;)ӲT6R(Kzn&:kA_6 H2Z~.c٠= 0G>kS&ssf/|$˟yhȕ.h [BSv59XIQ3 䝫Ц۞:uH6p"DsO8,oq8/rM-r!h9BDŁZ 5rPR q:|p%*,BՒh|jZK}+3\7eG8pTE)?k-hH$ٔly!a@R@*:G&k'E]y@d`{o)k4t:WN],b:K)+ICp9VTt0Z+$.rCbj8\:k_ 9?֜>"{-r$o1F/0@a')o1lg.P8Jجѐ zj4EVIDӆ'aӉ$6X b;yo*'}$J(;>N>Y 4xː^F0*L/,ScMKVm Fm%Duln6lM#prTVK!s??Sc3ȭ93;%&n"U\:q %ASq:T!3 &<%)ʨ $9ݐAM/h|TMHJ ˥hdr%?ل^ QROAPYܟ$.$P";1&?t`+#_G| >B6ޣa/7Z4y?'rIs P=e;ļd8mIJZʔTl|erHr q9&uD=Ԭ8[]6&7J &sRܹhЛu ,qWތ$0q>f8\&2B&V>bBbY t}#;Joބw&a1V>a`}#;JoބO&DB>ɶQ;&y>꣌<+T~Y\0ߚ;بg--s k8@9EGfnKc,#6ؔ'@/!hƩJ12Jœr9$X'W_LLjc3c4ҥHQ|Y:H^6Xul8PX$ c)FoX`v226&ۻ]v-;0E {mzpL`4yn6OҌ 8X :TthZwe W4@ kb9"ce#u\qG0b.V2ݍJҷHHe%)qR Č{ }4GNv[vS#0=l^:x# \Dҕޙh琄Y;E`T.jZ9bƤ[xJs8Pr 2؉ȭ1bid%@H,`}F@7>FpCgy-ُ"6VZ6D,g-9 ,(Ѵf@+M; [ѡRTH 4x::jRpP"k(j\ٌ]l!-`NJ6LW65h1nt ![f>c0%8hх<~n\\XqNac؎E+a.su+@,* n.!J *9dK!;HH)WJT'6#HcZJdU#y[2CAh"/p9,zLXޗa։)R”Ɔ*Rgv#r'aP ʦw}e Mq2uIKUO y `܆DlEa̴h dk&rGVJ<=,6>Zp`tlP NI 9@:-yf@dw%UＭ;)vJ0 X \vV\G rbʓRR<:M3F^EIFvPE.FpoZ3ǧ,48^PPBR΢f8C 0vߢTq8ԐR,Vׯ%o5%akXa=#Z ^5GN.Y3\RO7JJGK,RZV8O'3(lL .} u:vn+FxdBRvV+# &X;G81*Z7!v2jԢUFFCQKgHp#wokۊBٖWYK竗!N;- &LDPJRATzbSm0h2 , V 'б:F K>sۿI$c'qy]Z䯖ۀ»ZbJ/5sVB'>v.jR78#*a,+Jl=rARpStwb85mdtnTp 4r11`xʹ'amnsSHPV}pM?&r$͘ iA`˜OANa6'-|S\rpVלD_;ˁY \eGv߽O&DB>ɶQ;K2Kcw߬boOG T_ep>jx8obN ݃k ȧ:N4<_ M|m=qR=(b$)dIu-,c6*CGq dE9JRT تHGYPhREe}+= &(䤆uLA.j8~YF\tR?#h|Fئlm[|:3:#eDZ 2LJd3 w8$6Ȗ6ׇD\12+!YIPY,uG)*LRN ;0>Id1tEfJ+T%qmYf=rDx]FcQQWϞ@IJ&E*~rMYDBfT17OdkR0ѫ +HdcrsefN$wity } ;؁;6TCR>7 W$*zv)A MQ^VIRp! HGz<4bh3ħd4=ѐ)\wht7ph-zG.82y! taͦ-^C@QGd)D+7y^5nP]M( DnJ15@;.6^( İ0vX{X\^xAٜסWQ 1>/.ihN+.nۅ*5US Lc%ĽGWJx3r@7.2ιLlT^q}c<>|.-Z5xF4r88쪌NsK)cpbO+ .lQ;%ֿ;Gan&$CCC{Q_5ER @qRhϔfe`g !F -G:T,q6 kTS$LPl 'RN= hB4%)Ұ =ȋI%_OK8?h;+sD[kjߙl0C(lZ\O)AJU1 i;|7(W3 RBҺф<%2H`v"[\VN.aRՔ4ed{pw}8ahw8A%S$2F#ź Vi (PB?3lB5:y_1˄qwztܐ1+NPZ&BKQNCH͐bz㠙9JtB8i+!gMI`IW£qp`JTůMaUTbXڕNEhц=m SH`=#7م ۽w1(g|bLY>rR蔔byIiR-%HLwS@5ݣ9 3J* P|;r4e,!opAw`BDɒh¶HK-`s.؈ =K%)$z]#99 VS@M #{G_VD8/n& k@,ԉP!qWۊLm1e?G(2FcBzK vFuƫ v2"k:ָ[9_hZu+)) Rze\CcHZIfhꦐHtӲ*A\6Ԭc@.lcLVҠS:%M$[U-(m`ٚP@I\9j ~2-@d b H֜gTild4]kk[u5W QVH-;0R`s#A9tAr-RE]kV;1Ȫ(.lD3LFI2GeәIߡb#,.^H^ydy`1S31QBmH~ɶQ;&y>꣌<+S~{Y\0ߚ;ب1 $#C(u@t^/Ao8tmuH}nmCC8"JB\V>0iRU6Q@|٣ET>'˲|2TbTV]E:B9)+x]-ǍuiѐLwlrdf-Mѣ7LQ0y=`)FZeMBoiD 6tyr$X93R@LŅ)﶐qH܋xa+ Y:Aas]{G7}msj($Ws@A"'HZ-5NA#3H- ecd \{z%f $$mQ܅`yFTM#٦񒘂SuC}D.ug;YF̙`,]嚐kai*ik)C6"2+@&_rLT,ϳD o1^7;d_x3plkݐu+ӊR˺k3:Q7}쏖O?)Otv\q Z:زԗlSYE+-.^fcls̖V i'lԲ7'5xdߌmuHkƍ4`}8+g-[Ụun #SN.؆N"ͷz[=%#K:Vqa4h^*|rVHӸ쫝 nnPK+k]#,RRJFhdK\4p@ 0N3 Mmv}Phe0 J]3/sϒSdJD^AѣamPjdO"cڧ.C$&ؗ$Qj-Ѿei/xs+*)Ȼ4kYO2u*VVT9؃2cDyJV1)HJYH jWR뼑͎Jf}>F ZPeᴇ5iipŅwšktMT:69&X ~G QekFPii,{#1k'pFqYOB=5<2$i&j3i@ߺ;Q&7IJ/"Ucç=JYT WE^8|>O)b<ЗEյ:2R3/p8U0=RG1ZZrpA4zFҷ9_8F +0۠V=/L|`+G"Ҕ2${,F'H` :m(IXLA:rcu2BǶ=&#yOĶyњ-.!2_?>#OMxb&)yqqssYDyy3+R=yl Ԗ|zaQ*X% $43K[elM1hsBlMo+nlor١6&77|,+t}#;JoބzA+@r9xDy?%7BO&DB>ɶQ;&y>꣌<+S~{Y\0;ب5sΡR@Mq=!:~K|T]S~ vv 9Me3,K3genjGS $@٢mSY6L!UОaƫ{G9 X:PSALu8GU.n$VoMCRZK66ف䜲ZSaw @mbpY7u=M/g+X2o"i쏓1k!O~1֐ټv|VԾC- $ss o^4 PK-de}Қ3JMX\q 7宲2f{ VѣGSVg#eDMus \eS^ Zo0VWH&H&_x# 4h`$UF %2=4ݹ q=sduFSDOw0218E;Ƈ W-Ae)aؚ$M.@fDbk% !L#3¼h!%i2EW|;mrlCQT #!´hp %Y9C &jsN̄A3gBq f/4#-vAlnx[ea*eCpc/a!#Ȼbt̊<a h&bi+XşxT*IUXn`s28$ZOrIcxёse'.ً&:SA?A2T;>vdRmT!/~+{)E(s'iA;?@5%e31(\{KDL8GŌ ZwsyD#.qyv*\M"NbAJKE0JrGD칹b+VeFh|3qܟ T4AF2]`b"c1LٮȐm(@&¥X&%G@Fͩe/H*JJ)lz튚0֜.\PI $!h}#;JoބzEoNgC~g`? MЀO&DB>IQ&y>꣌<+S~{Y\0ߚ;بYM'Ț|{#䜲"z@ 0T=.RfKX:0TODq uȟDK<Y\1 {=kdPǴcmzUhwFPN]pPE6fYl}X_{ݨ*$(.mR"q@ltZ\vRwHP cTl@xKHE) gZ.ԥZ3BQIFJҒLWE-cyh6jbPf:9gucp;PchmuzǏz 睗Is@ *ONejX4Ckc2sdN7F'Sv'*F4)+ЖI6'XUha,V9PP2c3D4W[ cę,6cPK;=IdH`4GafN)YXFHat3.(%i$Z)sӎK@?RRS'bB%جǣO)XURmbY,:(ᔞi$[ÄMmG._ nH)k9#a`wÆL~i\vZsA0)r4vX4_ )iAq׭ ##4jKO cǍ e65WspB֜,<@ 2p )]-WKsYR exa*||Qo!7oTejwJLR!{7qݚ!y7xϟzi^x`l1\a'R0"|2elr^W$ybz\z0HDA'J$: ea <\mft:핧\ZV Zn/76<@qegb%(!-!qJ d  N_[QSUP+^\鵭::($]0-YC,mɱ(/b3 1Fz~N&F' XϮ:~VnY,-aqpxq0vFAs#5;!X*p3E3!Oy8xu7**h<΍0ܛȦCQ=!+tIek1=X9IQ&y>꣌<+S~Y\0ߚ;بET4h<ԑTWE݅w*&JhF&c1]񄞆ΕqTk x`Gz0|)eh|Pqmcѣ}212=cKiDW>[SNrK.JTf2(OEa-2)g@ W6XK;i1v"h_g>Q Ff' \<;'eUs6D-Ї>[zȖ6p˖JMM12N$*9.ZuFZ.C"# JT"cNCi\&n).7]bsz0r`6i ԥfMdM>zZe rR@ (A.yJ9YvH*% @ :~rj8nC06yP,Ғ!3@JK[ʄ2*M$((~xtH0ehѱ>4MJ#['ȳ\IHA:F. ,fI-LpJGzuH@HV%7 _=ka.﵇sTM$ϒG)%N&I`nxn{֍Lq*u$-D^\) !$вpjL#mVkPA!~wRTx[\ dx[C1d*>|r'R(4q1un*bS#7KLW;~uslk0ݍX`JN)< ܁~Pax-i.i 'GLp5)je%)Rd拓 a˚)JRI9e, J"#4JRTӶ9%`9I)f\&{≡q;1\WSnu/Ej]c)7t7oF<!X QWtTEe-B)$a-bi:`xrBRKKԖ&ȗ2*^ebʨn\YP;xDdw%i8&7'N!jvzN$ԥZV~ex -scde6&6їI8I^:f`.hhHt,A@b/ >|=R#'SsmA3*0-GG"gr3!?3G_V}>Gv߽O&DB>ɶQ;&y>꣌<+T~{Y\0;بET4h_DNJ>Y)rŠ6Fи} n8$FG)@N)J& /XpRY)`JBvlnӵ/,^xޡ`mɵ7iM+4xJMi@q:.Ij*E7p*@_TuK\4A #|w$)R[1c0-3,(Н)  t 5[qȯ{&z&Mk㼵ē^oKָ85<05Z vx.Z6fǺ&vG[G$a╳)j9\c F{?qm|όt-To7̭ǵJE%g1I򀒙fT jpw~D/eԅBz!|y  fyG2za YБ|Wq8xZv73sZt'JJB%%%JpP%{EOH5Ih#ʉD8I;=.|3S%Tqn #^[h&Y^IE5U9XnszYPZv|O&&H GjWqꏮ.1)D` tN:F;q/R,!N ܓ|I]=;S'Y F?ʧHIly)E+ F nu*CySId(ICvG$\2uI]g`rk_E4A:Ѥ(]lw:ɣTWhֶB5xP9mECl%bۣdϘ+HQۮ8Љgk`Z1zXpu@K:F,lVˤ}Q|RhO {o?IJlOlNd`9}I0N@rl-R6J,5HsN4y:04smaaUi9,ekWZ-{&VÔ@ڱv#HddT(ZTz%ZmGș!RR`t0v 5U1GLțSG桌̄0R%;J Y$g_d(Ib :#rw'H¨V0FZ1YNXuZ'd;}C4.>zA9cMY,^F:;f内2G`yW*8'"v0 Pc+' QG+[iXPbsDm|kHWW[+yVRnp=# vJ$+.G%"ZF`4y&aJz@J@؋F@!`"(hh0/4VlRܹmЛu YK*rBlMo*R?2}y97m9xDy%7B="~f3!?3@O&DB>IUJDq;g>r5jBg9%Ns.:*='}}!߄pE;W1)q8ZglCa < wZ*QY%<еk8&Zt(:H#P^mX#GF? Zʘ e K91QD`ƍ4jd jp7avzk Fу9njA,MV; b#<"r~a19\t@W1Ke( Jѣ¤BPVȡ:iqKN=Q) G9dw@.gJ@T؁F2uR7}4GA*Z8n ku\lddE{cmJ!Z; v]RTMc6_+GxԺ$eGAUa7XxDe-jwBa3V9@J5/쉯 =+O8) g$%;! }ZEp8+F l;OlpKR-)NI%E+HR 3-9P1ųܪi-ɧZ6N@xVPdI&e$H!{]XfTԑhXSp (O 8n}zq_o'ȴ4srY{YX a<7+ꍃ΃2K4ڤv|&`iPK0IY%ٓf"n|_Zѣ&p-PP|>=Bc[6G,::k%"ٜi'EWQ;)!|ɟi(9n @S 8RD4C3puY2E:GoCvSkZ;r'j2g(071sR#m.E{"x:C3p1R "\Z:Lf9Zmn:֍DVnyRK/WhJ6ːuGN0Z$Aa$#|˕s)n`衛&20/-0UMJQ9"3= +⦙GS;PQ$KE:JPrgMmiYz15 `otMD&J:)$q{]n$JWiaf R0Xѣ_+Ją"\Isy籓LűXa|D­A 3j7ƪ6ͣDLe:NWUSɲֶ׮(yڭ HT>zfRܮy&;,.N,!)RUP?BLGg׾wւ\nt7K9ܬs b<vZ$3o"c&e.1͔n̉;HZs)!1vԥPbΈܔ+A璹Fi:)"Đe!H(F#@x/QuEAbUf؛pV:͊_V-bn}R8F'+U1r'o*s>?}#;JoބzC_NgC~g`? MЀO&BM4\Y$nl:3k؋ DǾ7c. ysDžx amhyalyC t 1—R5rfxuvKCҭ9%r6&$-%cy5x~p1 fL )Lc6N-(XݸQGQ 4 lg)&׳N90GJd+!@۳8cU'12hE"Nmr1W!*rzxtKmL8,BhmkA\4\44pXY595AZk\Rn"ӴY3+('b`oRGd)D篫? 1%Dd@,mY!gh+&abdRR6 |SO]#ƥ' #_}NϽLW0L $K8anJ6nR*PD&-倏wesd2G3i9I9 ""֍ f3|<qAeAt,xIHȥsuj*kW7Z4rauH. (8*l. "eK*50ht-D8 QT8z)$%M_!i P%!Bs6HEhU(%ޤW9p $՚8;+Z65{Ef,aV 쥁vFþjѢ6@ ,ڣ8զP۔TLZHb 7sː+F**r6La솑$2ke3 XBPږmGK:}w*jPF,2 2|! **aR tYh Y Ґ+hTևRx+Zr] F:9Iha/t1>NpZGCrѣ3Iр )2^">-'d0qEZ4T@]#Z:oZ ݽtX#2\ #6bQ('GPՈqZO-G5&T  @&T M{i@u($jHjKGC$(vG,Т'd}Bc/RM,x]髤.M::m? cֻ"mt l'hjLbl3q Z:Va3HJ' IDxqcoCɘHfLEY\ٻ2TV sȼ-AI `R#pz SX$b:bn*a`:YBF =,?-kcs;<4`[ٌIFL^f$ĬY^ |єRhAMVD+G&HX -]lOZoDxLHvQ1Pc8UճH ;rMI_yNopLÚ#7*.HNp\[ A|q@:VZ4S5ѽxp얝3L̨x7 -k%42-l`~ҀPugԦ1#֏)6O6h*\1 \t@=6r\2֕}3?WO - C.8x6 #3鋋4K UbM]ws4-g+ n*j .PX?Ub6Ϧ!)@!D sR蒃-VTd ``}M#$ችVڠi͆s[nggiCzt(T䨙<%iE\Y㮕3$N-V9Co(c4yQ^8(#=UD*iq]}@YqW vaopJ1b>Mt>qOƻ?TZ(RDM/#2.Ճ!)C}*%I! CYg~*}[#hhSlsØb|J3Q%*$$PH$d8#"Z9^Ed$1w]8,99nZ&ffOIk6&7e $E.^  o//eS)BbS V#aTk9 S;BH~!50+Z nkP$Ǘ,u`u=e^̬0x 2yɳT)IMV%L;4ǧ*&䞸Zjmq\*h,Xñy@ skM?4 |>h3|hɘ1ZyS,`&Hڔ}QEvoF7ϊ٬k*DuF('+GIVgX˓ˎv%`^6kzѥ`<,YwGJFjY: FeG{: xWZl> zЉ7Q?_hM1O=Fၭ'^?f.D9gw`sIh*QE_ 9:P5#0A$ƍ}8_#!T<Ŀ#sH":_ƻ=ckhR?O㶍1h_GſJ5#Q'g\[O#9U(J()$?wN1h>_N|k{ݴI\L%%@::;J0Eae"XQrcGsQEAM`4EQh1FEZ4hѣDQEţF4uEZ4hѣDQE4hQEF4EQhѣF5Лu T]h}#;Joބ}">q?3@ endstream endobj 1820 0 obj <>stream xmp.did:D98F57F2EAB4EE11A00290D41B5DC313 endstream endobj 1805 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.225 Tw 10 0 0 10 70.8661 724.8299 Tm (\214\024\n\024\027\024\f\024\r\026 \f)Tj /Span<>> BDC ( )Tj EMC (\032\026\035\024\002\026\n\017 \027\026)Tj /Span<>> BDC ( )Tj EMC (\027\036\r\024\n\024\032\027\024\f\021\034 \023\024\035\027\024)Tj 0 Tw (-)Tj 0.012 Tw 0 -1.218 TD (\006\036\027\027\024\020\024 \022\024\027\021\030\024\035\016 \022\017\001\ \036\004\027\024\020\024 \f\024\007\036\030\032\017\n\024\020\024 \023\024\ \f\035\036 \030\024)Tj 0 Tw (-)Tj 0.012 Tw T* (\007\024\r\024\005 \021\030\026\r\n\t. \222)Tj /Span<>> BDC ( )Tj EMC (\027\017\b \023\036\030\r\017\004\027\024\030\024\032\026\r\001\017\b \002\ \t\035\024 74%. )Tj -0.022 Tw T* [(\221\030\036\007\027\017\005 )0.5(\r\024\030\026\f\021 )0.5(\023\026\006\017\036\027\021\024\022 )0.5(\f\024\f\021\026\r\017\035 33)]TJ /Span<>> BDC ( )Tj EMC 16.707 0 Td [(\020\024\007\026 )0.5(\(SD)]TJ /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC 4.349 0 Td (5\), )Tj -0.063 Tw -21.055 -1.218 Td (\022\024\035\017\004\036\f\021\r\024 \030\024\007\024\r \024\021 1 \007\024\ )Tj /Span<>> BDC ( )Tj EMC (3, \026)Tj /Span<>> BDC ( )Tj EMC (\f\030\036\007\027\036\036 \r\030\036\n\016 \f)Tj /Span<>> BDC ( )Tj EMC (\n\024\n\036\027\021\026 )Tj -0.104 Tw T* (\023\024\016\r\035\036\027\017\016 \f\017\n\023\021\024\n\024\r \007\024\ )Tj /Span<>> BDC ( )Tj EMC (\024\002\030\026\013\036\027\017\016 \026)Tj /Span<>> BDC ( )Tj EMC (\023\024\n\024\013\034\033)Tj /Span<>> BDC ( )Tj EMC (\227 39 )Tj -0.055 Tw 0 -1.218 TD (\n\036\f\016\006\036\r \(\030\026\002\030\024\f: 0\226240)Tj /Span<>> BDC ( )Tj EMC (\n\036\f\016\006\036\r, \n\024\007\026: 24\). \200\f\036\n \023\026)Tj 0 Tw (-)Tj 0.039 Tw 0 -1.218 TD [(\006\017\036\027\021\022\026\n )0.5(\023\024\f\035\036 )0.6(\023\036\030\r\017\004\027\024\005 )0.5(\031\f\021\026\027\024\r\022\017 )0.5(\007\017\026\020\027\024\026 )0.6(\002\t\035\024 )]TJ 0.08 Tw T* [(\r\t\023\024\035\027\036\027\024 )0.6(\224\217\211\003\222 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 8.527 0 Td [(\200-\030\036\032\017\n\036 )0.6(\f)]TJ /Span<>> BDC ( )Tj EMC 5.143 0 Td (3D-\n\024\007\036\035\017\030\024\r\026\027\017\036\n )Tj 0 Tw -13.67 -1.218 Td (\017)Tj /Span<>> BDC ( )Tj EMC (\230\215\211\003\222 \007\035\016 \024\006\036\027\022\017 \r\t\001\036\031\ \022\026\026\027\027\t\b \023\026\030\026\n\036\021\030\024\r.)Tj -0.035 Tw 23.244 10.96 Td (\200 \030\036\031\035\034\021\026\021\036 \007\026\027\027\024\005 \023\ \030\036\007\024\023\036\030\026\006\017\024\027\027\024\005 \031\035\034\ \021\030\026\r\031\022\024)Tj 0 Tw (-)Tj 0.114 Tw T* (\r\024\005 \007\017\026\020\027\024\f\021\017\022\017 \002\t\035\017 \r\t\ \016\r\035\036\027\t \007\036\235\036\022\021\t \027\026\030\031\032\027\ \024)Tj 0 Tw (-)Tj 0.121 Tw T* (\020\024 \f\235\017\027\022\021\036\030\026 \f)Tj /Span<>> BDC ( )Tj EMC (\007\017\026\f\021\026\024\n \n\t\001\036\004\027\t\b \r\024\035\024\022\ \024\027 \024\021 47 )Tj 0.03 Tw T* (\007\024)Tj /Span<>> BDC ( )Tj EMC (116 \020\030\026\007\031\f\024\r \(\217\017\f.)Tj /Span<>> BDC ( )Tj EMC (6\). \212\017\026\023\026\024\027 \030\026\n\036\030\024\r \007\036\235\ \036\022)Tj 0 Tw (-)Tj T* (\021\024\r \200\202\221 \f\024\f\021\026\r\017\035 \024\021 76 \007\024)Tj /Span<>> BDC ( )Tj EMC (177 \020\030\026\007\031\f\024\r \(\217\017\f.)Tj /Span<>> BDC ( )Tj EMC (7\).)Tj -0.004 Tc 0.029 Tw T* [(\203\026\030\031\001\036\027\017\016 \006\036\035\024\f\021\027\024\f\021\ \017 \f\021\030\031\022\021\031\030 \n\t\001\036\004\027\024\020\024 \022\ \026\030\022\026\f\026)-4( )]TJ 0.17 Tw 0 -1.218 TD [(\026\027\026\035\034\027\024\020\024 \022\026\027\026\035\026 )0.5(\r\t\016\r\035\016\035\017\f\034 \031)]TJ /Span<>> BDC ( )Tj EMC [(\r\f\036\b \023\026\006\017\036\027\021\024\022 )0.5(\022\026\022)-4( )]TJ 0.147 Tw 0 -1.218 TD (\023\030\017)Tj /Span<>> BDC ( )Tj EMC (2D, \021\026\022 \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\017 3D \224\217\211\003\222. \211)Tj /Span<>> BDC ( )Tj EMC (8)Tj /Span<>> BDC ( )Tj EMC [(\(22,8%\) \023\026\006\017\036\027\021\024\022)-4( )]TJ -0.009 Tw T* (\002\t\035\017 \024\021\n\036\004\036\027\t \030\031\002\006\024\r\t\036\ \017\n\036\027\036\027\017\016 \035\036\r\024\005 \027\024\032\022\017\ \035\036)Tj 0 Tc 0 Tw (-)Tj -0.004 Tc 0.041 Tw T* (\r\026\021\024\030\026 \f)Tj /Span<>> BDC ( )Tj EMC (\004\026\f\021\017\004\027\t\n \024\021\030\t\r\024\n \036\036 \r)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\022\f\017\n\026\035\034\027\024\n \027\026)Tj 0 Tc 0 Tw (-)Tj -0.004 Tc 0.083 Tw T* (\023\030\026\r\035\036\027\017\017, \031)Tj /Span<>> BDC ( )Tj EMC (3 \023\026\006\017\036\027\021\024\022)Tj /Span<>> BDC ( )Tj EMC [(\227 \n\t\001\036\004\027\t\036 \023\031\004\022\017 \035\036\r\024\005)-4( )]TJ -0.048 Tw T* (\027\024\032\022\017 \027\036 \024\023\030\036\007\036\035\016\035\017\f\ \034 \017)Tj /Span<>> BDC ( )Tj EMC (\002\t\035\017 \026\n\036\013\036\027\t \002\036\f\235\024\030\n\036\027\ )Tj 0 Tc 0 Tw (-)Tj -0.004 Tc 0.138 Tw 0 -1.218 TD [(\027\t\n\017 \030\031\002\006\024\r\t\n\017 \021\022\026\027\016\n\017 \023\ \024\027\017\032\036\027\027\024\005 \220\b\024\020\036\027\027\024\f\021\ \017.)-3.9( )]TJ 0.22 Tw 0 -1.218 TD (\212\026\027\027\t\n \023\026\006\017\036\027\021\022\026\n \r)Tj /Span<>> BDC ( )Tj EMC (\026\027\026\n\027\036\036 \r\t\023\024\035\027\016\035\026\f\034 \r\026\ \022\031)Tj 0 Tc 0 Tw (-)Tj -0.004 Tc 0.085 Tw 0 -1.218 TD (\031\n-\220\022\f\021\030\026\022\006\017\016 \023\035\024\007\026. \(\217\ \017\f.)Tj /Span<>> BDC ( )Tj EMC 11.721 0 Td [(8\). \221\035\036\007\031\036\021 \024\021\n\036\021\017\021\034, \004\021\ \024)-3.9( )]TJ -0.023 Tw -11.721 -1.218 Td (\024\023\030\036\007\036\035\016\036\n\t\036 \030\031\002\006\024\r\t\036\ \017\n\036\027\036\027\017\016 \023\030\017)Tj /Span<>> BDC ( )Tj EMC [(\022\024\n\023\035\036\022\f\027\024\n)-4( )]TJ 0.22 Tw T* (\224\217\211\003\222 \r)Tj /Span<>> BDC ( )Tj EMC [(\023\030\024\036\022\006\017\017 \035\036\r\024\005 \027\024\032\022\017\ /\023\031\004\022\026 \035\036\r\026\021\024\030\026 \r\024)-4( )]TJ 0 Tw T* (\r\f\036\b \f\035\031\004\026\016\b \002\t\035\017 \023\024\007\021\r\036\ \030\032\007\036\027\t \017\027\021\030\026\024\023\036\030\026\006\017\024\ \027\027\024.)Tj 0 Tc 0.234 Tw T* (\211 \021\030\036\b \023\026\006\017\036\027\021\024\022 \(8,5%\) \f)Tj /Span<>> BDC ( )Tj EMC (\007\036\235\036\022\021\024\n \021\022\026\027\036\005 \023\030\036\007\ )Tj 0 Tw (-)Tj 0.419 Tw T* [(\007\r\036\030\017\016 )0.6(\r\035\026\020\026\035\017\013\026, )0.5(\002\035\026\020\024\007\026\030\016 )0.6(\224\217\211\003\222 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 18.029 0 Td (\200-\030\036\032\017\n\036 )Tj 0.231 Tw -18.029 -1.218 Td (\017)Tj /Span<>> BDC ( )Tj EMC (\f)Tj /Span<>> BDC ( )Tj EMC (3D-\n\024\007\036\035\017\030\024\r\026\027\017\036\n, \023\024\n\017\n\024\ \r\017\031\026\035\017\026\006\017\017 \017)Tj 0 Tw (-)Tj 0.248 Tw T* (\n\036\027\036\027\017\005 \n\t\001\036\004\027\t\b \r\024\035\024\022\024\ \027 \203\202\221, \031\007\026\035\024\f\034 \024\023\030\036\007\036)Tj 0 Tw (-)Tj 0.317 Tw T* (\035\017\021\034 \f\r\017\013\036\r\024\005 \007\036\235\036\022\021 \026\ \007\027\036\005 \f\021\036\027\022\017 \023\030\036\007\007\r\036\030\017\ \016 )Tj 0.343 Tw T* (\r\035\026\020\026\035\017\013\026 \017)Tj /Span<>> BDC ( )Tj EMC (\007\017\f\021\026\035\034\027\024\005 \004\026\f\021\017 \030\036\022\021\ \024-\r\026\020\017\027\026\035\034\027\024\005 )Tj 0.185 Tw T* (\023\036\030\036\020\024\030\024\007\022\017, \004\021\024 \023\024\007\021\ \r\036\030\007\017\035\024\f\034 \017\027\021\030\026\024\023\036\030\026\ \006\017\024\027\027\024 )Tj 0 Tw T* (\(\217\017\f.)Tj /Span<>> BDC ( )Tj EMC (9\).)Tj 0.22 Tw T* (\222 35 \023\026\006\017\036\027\021\024\022, \r\022\035\033\004\036\027\ \027\t\b \r)Tj /Span<>> BDC ( )Tj EMC (\017\f\f\035\036\007\024\r\026\027\017\036, \030\036)Tj 0 Tw (-)Tj 0.212 Tw T* [(\022\024\027\f\021\030\031\022\006\017\016 )0.5(\f\235\017\027\022\021\036\030\027\024\020\024 \022\024\n\023\035\036\022\ \f\026 )0.5(\002\t\035\026 \r\t\023\024\035)]TJ 0 Tw (-)Tj 0.086 Tw T* (\027\036\027\026 \r\f\036\n 35 \032\036\027\013\017\027\026\n. \221\030\036\ \007\027\036\036 \r\030\036\n\016 \r\n\036\001\026\021\036\035\034)Tj 0 Tw (-)Tj 0.185 Tw T* (\f\021\r\026 \f\024\f\021\026\r\017\035\024 64 \n\017\027\031\021\t \(\030\ \026\002\030\024\f: 30\226142 \n\017\027.\). )Tj ET q 70.866 378.516 221.102 214.3 re W n q /GS0 gs 221.1023475 0 0 214.3804669 70.8661504 378.4348643 cm /Im0 Do Q Q q 70.866 165.796 221.102 210.72 re W n q /GS0 gs 221.1023475 0 0 210.7794385 70.8661504 165.7366045 cm /Im1 Do Q Q BT 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0 Tw 10 0 0 10 291.9685 165.7959 Tm ( )Tj 0.061 Tw 9 0 0 9 70.8661 154.9959 Tm [(\022\t\217\210\b\002\220 )0.5(7.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf [( )0.5(\230\004\n\202\032\026\003\003\026 )0.5(3D )0.5(\230\212\214\221\215, )0.5(\026\013\t\025\026\023\022\021\n\031 )0.6(\t\031\006\031\021\025\031. )0.5(\201)]TJ /Span<>> BDC ( )Tj EMC 23.567 0 Td (\227 )Tj 0.011 Tw -23.567 -1.2 Td (\030\031\f\031\013\024 \027\021\205\024\032\031\021\021\031\202\n \t\f\025\ \021\013\024\031\032\026 47 \202\032\026\030\205\t\n\027. \213)Tj /Span<>> BDC ( )Tj EMC (\227 \030\031\f\031\013\024 )Tj 0.159 Tw 0 -1.2 TD [(\027\021\205\024\032\031\021\021\031\202\n )0.5(\t\f\025\021\013\024\031\032\026 )0.6(177 \202\032\026\030\205\t\n\027. )0.5(\222\032\026\t\021\026\002 )0.6(\023\025\021\025\002)]TJ /Span<>> BDC ( )Tj EMC 23.567 0 Td (\227 )Tj 0 Tw -23.567 -1.2 Td (\013\n\021\024\205\032\020 \021\031\025\016\003\031\021\031\021\021\n\202\ \n \027\021\205\024\032\031\021\021\031\202\n \t\f\025\021\013\024\031\032\ \026.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0.203 Tw T* [(F)-16(igure 7)124(.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf [( ER)27(US 3D sonog)14(ram, axial section. \201)]TJ /Span<>> BDC ( )Tj EMC (\227 defect of )Tj 0.091 Tw T* [(the inter)-14(nal sphincter 47 deg)14(rees. \213)]TJ /Span<>> BDC ( )Tj EMC [(\227 defect of the inter)-13.9(nal )]TJ 0.086 Tw T* [(sphincter 177 deg)14(rees. The red line is the contours of the un)]TJ 0 Tw (-)Tj T* [(chang)12(ed inter)-13.9(nal sphincter)]TJ ET q 303.307 165.796 221.102 180.977 re W n q /GS0 gs 221.1023475 0 0 181.0110436 303.307086 165.7612254 cm /Im2 Do Q Q BT 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0.052 Tw 9 0 0 9 303.3071 154.9959 Tm (\022\t\217\210\b\002\220 8.)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf ( 3D \230\212\214\221\215, \013\n\t\n\031 \013\n\032\n\021\026\032\021\n\031\ \t\031\006\031\021\025\031. 1)Tj /Span<>> BDC ( )Tj EMC (\227 \033\032\026)Tj 0 Tw (-)Tj 0.07 Tw T* (\027\026\002 \021\n\204\013\026 m. levator ani, 2)Tj /Span<>> BDC ( )Tj EMC (\227 \005\031\t\f\n\032\003\031\021\021\020\031 \032\205\005\203\n\027\020\ \031 \025\016)Tj 0 Tw (-)Tj 0.076 Tw T* [(\003\031\021\031\021\025\002 )0.6(\027)]TJ /Span<>> BDC ( )Tj EMC 4.511 0 Td [(\016\n\021\031 )0.6(m. )0.5(levator )0.6(ani, )0.6(3)]TJ /Span<>> BDC ( )Tj EMC 9.048 0 Td [(\227 )0.5(\027\021\205\024\032\031\021\021\025\017 )0.6(\t\f\025\021\013\024\031\032, )]TJ 0 Tw -13.559 -1.2 Td (4)Tj /Span<>> BDC ( )Tj EMC (\227 \202\023\205\005\n\013\026\002 \033\n\032\203\025\002 \021\026\032\205\ \204\021\n\202\n \t\f\025\021\013\024\031\032\026)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0.065 Tw T* [(F)-16(igure 8.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf [( 3D ER)27(US, obliq)14.1(ue coronal section. 1)]TJ /Span<>> BDC ( )Tj EMC [(\227 r)-37(ight leg m. )]TJ 0.099 Tw T* [(lev)16(ator ani, 2)]TJ /Span<>> BDC ( )Tj EMC [(\227 shapeless cicatr)-36.9(icial chang)12(es in the zone m. )]TJ 0.111 Tw T* [(lev)16(ator ani, 3)]TJ /Span<>> BDC ( )Tj EMC [(\227 inter)-14(nal sphincter)61(, 4)]TJ /Span<>> BDC ( )Tj EMC [(\227 deep por)-40(tion of the )]TJ 0 Tw T* [(e)-15(xter)-14(nal sphincter)]TJ ET 1 0.68 0 0.12 k /GS0 gs 70.866 570.909 21.907 21.907 re f BT 0 0 0 0 k /T1_1 1 Tf 11 0 0 11 78.613 577.8745 Tm (\032)Tj ET 1 0.68 0 0.12 k 70.866 354.608 21.907 21.907 re f BT 0 0 0 0 k /T1_1 1 Tf 11 0 0 11 78.6186 361.5739 Tm (\225)Tj 1 0.68 0 0.12 k /T1_3 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\033\030\031\030\213\b)-20.9(\035\231\213\233\t \021\032)50(\b)42(\032\231\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj -51.938 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 23, \023\0221)69(, 202)69(4)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 23, \023\0221)69(, 202)69(4)]TJ /T1_4 1 Tf 25 0 0 25 28.1774 56.0378 Tm (76)Tj ET endstream endobj 1806 0 obj <>stream Adobed     '$''''$25552;;;;;;;;;;   ####''',,,   ####''',,,   ####''',,,""   _!14AQq"a#23brBRT $%&'()*56789:CDEcFGHIJSUVWXYZdefghijstuvwxyz q!1"AQa2qs5Br#RS3b %DE$&'()*46789:CFGHIJTUVWXYZcdefghijtuvwxyz?HجI3 P5M .ؽ_Lo֥ՠbm*qc` l7p.uX]+t+IbΥ-o#XdbMi׿~IfuǼ]z=˶/C#E#^rN+U5NӯJ]Zz[lvձ/~KQƐ+,֡* GqW1)뫎TcnI7:;y4-eClJ=ҩ 7RovI⿻8пw͕;.-t/etjQ~KQƖ_* ,SO^_vW׮weCluk+R~_4Tibx4*s.-t?eN˭K] {]q- G] [쾊ҮNtSO%SO}䫛M[~SSU*OeU/Ζt_E[WXb+Jf*W7O5o'MtU}>_,쾊ҮrSO%SUuoO5o'MOj#OR^o(8bV(7 Ǝ]ej'&FOD͹="Ztçc`zEi+B<\!GyswOQjN~>J,Se}z8|g՞)9?RVZ~y *uW\t2AڟL~E:oߟPX=?vW׫Q?^$;'zXuANHL|N[O Q:mEحT^}j##'r\UX:KYrкPJK !7ҺݵܓT4c*|`uM}5H"9fr(z5H' K$!f:"_bK(;[Z@Ni΁EU]NQ\9/|%V~\=UUaPT7BuO=4!b/G>>N 䎡w~uQ:n<&*KInSD'uϹ՝7֡j(; _HVDX7qWGg#whh@9nHZٌRtu )y>IBӳ?}FvIOS۝#JyahQ~I7RڙM4tY Y}YSH1'Ќ+tO֩>>arEfto~./3}uJҰ Fy>I}UV) c6蟭S4}}j9n3:7?SuѾT^u4ytKO`Εi{S8Et?U;?UsWUO'UjzJ <[1MWWR+F~ '+'S_U?wNoYPyҷ}->c}ä j4+u4 gҪ~sO?TWpZf ֎֨Pucօ{Ti8"Gj4{OCez9msΔ-kAvI :)=`NПvëmm?C]MnMma$Ѻ=:="=][/SIpkMnO[u].rMԑi,t"֗ ,張_w6go'~qG.iuh8?W*Z9sUz\{׮G@c= ,X6J+,XJ*TXb*TRbŊTRJŋ)RJ+,XJ*TX;TRQ I`7}wf+ ="<5 P+EJb^6$P1wu2pn41p6}FGjTo0~}Z|D`?7Kk1Rh-QJOݸB 4(oHYBX&ZV\!eTTloH In 4jN(Œ?֭]Z Z)RNGiZĻ_\L8M1!w)ŠmeP*PV@}jw]$ݻ}Fp!0d$ЦVy9:J`L1z7y~]J+[i,v 9W$>!_lt+}Ǵ8^k(JmE@8PXB'Q1wm@AkKk)RБDAlQj@)RWh.dX2wR7VzrH-UJm0Y ?Ek@b%cZ~FHƄZB=KWRUN1_T"X wBX4%nao JUWnf6H^*EiXb*TRbŊTRJŋ)RJ+,XJ*TXb*TRbŊTRJ4zJ?ڐQfQԂk{Ώ;=\TYr:w=SfG.iux8?W*Z9sUz\{׮G@c ,X6J+,XJ*TXb*TRbŊTRJŋgRJ*( $5L-謳'*U.}-T~aNYLY8+Il1IntMetԩ*Rma՚žP ,0$NBo0,*T|k $c"*hEEJ(ʮRI^|Zm^Н%ZսCZo[]6(~P+ME)m EUJ[R 4ZU9`JGZґ J9յ)(pK@Nc\Ud33[V TR ^TC`BPmAME6K[; rx E۔IRЅi --,VxaJn\PP q-ɩ"R6wHL|a Tt}/Y|.Z@)O]K,2Du#M #}bK&}?CK3wB^^{[U56R̆>Zƶb*RO1TKaBX*bť*TF4P1)V*R9O>" b*RfYրl`Vv([LSn TT Mԃٺڼ!5\R$0[<}SkaLwHbZkMB(keŴr+֮(6 2ք̒}3Ez::JT\^n[vw1 ш;KV\!]J`I"뛝WIZFXwk * I0C|\-%~ii ҲgaohޥU{ktb핅XP9›^+˝D_dT]6?A}0i]A9擼TV,XJRJŋ)RJ+,XJ*TXb*TRbŊTRJ4zJ?ڐQfQԂk{Ώ;=\TYr:w=SfG.iuh8?W*ZwsUz\{׮G@c= ,X6J+,XJ*TXb*TRbH }@ἜRJ+=q+^Vi'mJ8O8\v+X|s ewv+3ags/땑`c- T)RtYzR;H`$kuڦOt7c̋. 7)dzYuIkt nЄ%?pIJ\=!IE33AJs#iRzw=P;:=sV=^o-]J*)I?Vn-Zn X;h'pR &1X˛i<LIۓs+^D[KrJ~>JOEeVCx}m.L̂vʽ_TtE%#H'p$^K+s֊W].3oVva !|\(jqn.ڮ߸qla>   2B*Vq)P$Jݾ6̰[Uûa֖ԣg3J]S)O&VJ6-﫶#V,KmHr@ ' լV`J]Αnܭekk\TYG.iuh8?W*ZwsUz[׮G@c= ,X6J+,XJ*TXN(3'*TXzӬuWGUBF)g%܇[L La6.n @QnϖBJ=Qc[.۲Jg,ɯM֮җ^QPǚoZt&P]eEܔ$;ogHd -"aBq}j<$8㺝ݔg[إU&%z*8~*l! ۹+}tBi r`*, =џ%(&ˣ-p ^;>fTmSm3M&K\'4/ta:y'ְ!$kЭh-ll/5~)zBSxh$!3RoR`$qG#Qx6 %DzFdJQ䗮g<*e&n*{PԬcJ *=|4ѺE[]'ސX JqC#rZ8Hv ﳟ 5ղ,V) @{Rx( "`]q]ؒVV%-WmEZ~h[-nkA݋EUJ%#,Js%C2G)`$L@:6`f]%a'y;0|:YtҖtF`$p} Ah$]\-귬B^ٺs;j_85;ʕ+*v Y'*!#pYq7!NR"eía`Hp>zٴz2vXHS2s,(! `[V|oWH *0_d6ˀ6:7o5hpvQJ% E `J^t4U۲]ŠAfM'dR7EzOfv6Ц 2}ƒАuTn HĂB\*np{*W[j/_)Ja9 w_HI bTkupy]9 #%@Mz fqd}z N(eiCuBPV\ӑH{HRj#,8VtNcJN Fbۖ[J-e@|aO5'rI$Nb@3|Ran*SA$*kbՍ],M͇L.j+Qo*V4 5iZT}[J2{Zo*P֟J 7.[;;+]Ar H4֊6N/v(n7]q+Oc(Fu+*NĞGpV] +쮍ߤkwZZ/v4?r%FAA`HD{:TќAfFXUu.-ia6zGBe cd},.{vPvT<}}ֱ I\λ꫗:ǡϥ[mM`qmZ$`|=Jdhh4.XfK cQY` \*V$!dA\~ѺGC_UBHw0kѺjnPNCxOAҺR *ޖ(8t=-b:밁V'uB@ȸ.Vf}S7UUJ?h0#t}¦u${]ҝE{:+ꞓktrRP[>J{uD-{h+,WR*TXb*TR7hi Z÷@v=DW#{3>kk\TYG.iuh8?W*ZwsUz\{׮G@c= ,X6J+f c Jl2<4m+uA-"*T ʺ$OA!@ykNGWt[!LJRtun UNүzROkuG[A/&>*e b?Y%vuJ$Z-ӛL: w\b=ۀتabKVLuػ,t4:0%G UtK,omJo, GCa}13P8nuLؙv& nהU”nOBdjӐ8_Du$# 8عzm{.WIiBaA%Zp.zLAk6\Sf-tpcrkHJU HczA_'Q˻]o~VĄ۶V@p᫤k,Zw Y$n. .sV%hgG+xvYC[8k-gxg(:Y\^q*;n?R׶/dk6-'iK/\^ouU*cÒwnG]N!WRӭ+@>5@LhwH](o}/u͛Z,i:Y䁸<Ѻ*˗zZʖvx֛J΢݀}7N0h+[Gՠ]Ջ<-.b]?` )R=[jջNemnj_ZtNQt%a C;ͿqoNZIPQշJSxU6]' 衱UF4vpXJڝRw=- |X+oEaմ@ΣrfͲ;JiZQ~hH![塵 54bOUh0_W;m1Rinɸ$d]>rHMR's\>~/lBcHF%8$ՔJ&ILˆ$"2 cAuz\zR +qVҸ&-qRSm"VO:H#ʵx֥c+X@TLWGJSH c˾ūV56<% u+Y[jүj%b Wz5֮{ce.إJւ;E ]Uyw:J['G IZWAVWimzz=t%smi:h=VZ43Q7oJg6Ql{k_pA|]=n+VIKC/TE}Z{Я=c>ӽh:T%l)ÖYm^kƖ,_ #?tk*ޠFOԉ-%֓]5hѼTԩ]J=M^V$)'Ͼ_j#q,'z2?ds,XJ*TFUGR 4zJ?ڐRwy۠Gz+ӽ5K5׮GNg|O,^G.iux8?W*ZwsUz\{׮G@c= ,XdI(.[MRp>]dЍ$%4H7DY;o['bw ݱW.,PdWZβ駢QETv$j,ZY*WJŔc w:lt[fz㄂Gi "N(jZC$,K7|ʧn (*66REwmZlˇSĞ5ӵn:;5_FymWkjYJRaԃRYee o#2J02B|7z*W_q) y;?V6Zqr纺nHDm+⫙:;]Mա(nrI"84`vɇ. `™UsB)R6^qWl_3νV-) g " mW-NHN#y5Bn[ *n>Άۣ X;6{Q4^sC@\;\=PJ\Uu@6cvU#Œ@bI PU׳ӕҊva }}v:?JwzGKMABBP>zӓ]A{ J&x5xݸ$r|{=:AK3$tndѰU֠QL6-ibUJ+7-;I- ?t5tzti֭ ]٩*^PZ[t˩o%n 8JR\qqV{3:B &NNvjk:15 +*k-v9}coO 7VZ^7"2TKzMqǫz}pvCC(a d TW_|p*ޒ\6<*aJgUuSػm7e$ 1ʽM~h,.KZ B\kz\M7mSqC9mX\v2/7MGpyRztYA++kOAnG @!ޚjxvI<%K5Vֻ)v9A V*٬y1: ]\pZ/H|4=ZR)޼7YISzH*N;xkjӕܶL'UK0`m ex*\H^:5UJ\"ib㫹}+nZ! H:l^6z  :g<^WѺ6"$,Rc,5Om144?X(FjM Zt,@XdBUK} xx#x?U/ A'GjWDVЁinWhwKZ8-[`@,"Rz!RP)v ?Z.RqfE`)’vWwIISg Qla̍6,!UJ*ЭZJKI@+m!=_a&= : iUԥݵfgwlS] IH@pA}E ʬ.*UJebF%[ }J}Ui$B觨@x(!ԀJV.doƹ`yJ+7Vg׬60X*[GK7 y[gWt£eԙ.]~vIRw^NʊOżW:'t4ꓐBMh)fca9vZigI3+]oїA`.5DA ir3͎E|T+KCצMt,.LZA)"ZqU%)RJ(y(jAFVGR U:<;t\cEr:w=SfOG.iuh8?W*Z9sUz[׮G@c= +4D-ڪϩbU|:Xpj.z-%S"ײ ДM l#WϮ DLM`$E[)-SnJTۂNN^IDۚeKNeVAd1Qz4g"68I"Y8B*󶪜 pSPmR +NV=8IW /\Vޙ|[.̀ۇummoZ%t uX V\C]qo+Q,FI3ԟ\tz[( V8'.5}ջ-k@ E:pTt{Sh! jɧٰlY2x`UNk]:6XI&%*RԵuJ}iuzRtZ,5oY -wR{h07n ];iĂ(m>;7!ԓPqCW`ӱJP]Aέ<9&IJR1p (W>%Ki$;>9oY b0!+mJUizM@9RzJ/i# *;>56\U6'u.(;t ;ٗCk\^w65 uMrRrΫEux}/MluP&Y^Pm<Ү F$ǝUޏqWTt!V@lw'ˠGJ{V4Gy L9 YZ٥;E CbV VXQb+{-ڼz/A_dS 8q]^m*B%@6o-A}Y Ň]@ޑ4\ X^M&vIlY!=y]9naاc6T%>4fOz_No\i'e q\{w,JWt JyFJ2'V/dNW:7bm}B Y VT.bҽm@mIkltgF<@\A[O{XDu U'A2YLѻi$SOe6;(hF>ZQ689maBU5"En]:Igƺ]>I s ~[H 5线m*T&Kv/fI +&yj4@/V!э" rR􆏌`R*vcsd:pU7N#kCAq%JOZt|,^+Q~H0XA#4}kp7NON:5IMwZAie lp^tvĺ41mp hp; i-WG-pu\ ^yv஥zh[;gC*.jЕ\H{7A>A^fIBAt!)>Mٷ-^Qm$dAսPhc\BNҮumL1QDIB(FjT[:nvWJkku ZXN9cwRW@hgَFV9-vK$[$AAZ`l+[1cU\ :>Ww/ZvێBD9'ȼKrAQtZ:%xFq J͢.J6Y]J@#kwXCfDZ}I_7l I.% hi GM*~w{";ٞ]?Գ]ztfztRuG.iux8?4^pnu^vk|]Uq/Wbَ+~{RY*݊=۱5 \%LdmxXX(toެ\ӤL(ZH1%*gI]-J*<֮\} bw_ 97>*c3S6UZY#g`CE;TD]>ܾHW:%$@<[*$>H/\LEh5#Vy^sao7")%̩xAH V~{nҒX9!י{IԐt|+? }#GF fLd3"uِ @қV:ğXWaJ+M[J.%J2R%wRB%I2H(YcWd&=ҏZ 8*p9=9 RYkAX \Vbkd\J! bw1Һ?XU:|sgI /\JA$|} *XjY5LN8rRu- F֟9 J]ҔJ$#JoBX(*6a#!'\+I47U Y@kEd~4@mX9mvJʗjطq`ECJ.$+.%6-AjvPoj7Fw&'gzʴų_=Z)EOP4m*TQv+2V0IUrMppH` ԤA;^~O=%gr4HrQF\jҕhdб^'{m;F>8H; mESbhDm֍Sg#"fѨ6vO 䫢Z*![=?zIVom v.ªv2m ݴvm[颳hꓕqɅ-rOIB0c6Kel!4UVb}!j xϦ ` '"y$*$q5VhjsD"YGY*m/kkchjJ>V:+8|#+p(/wImc) *RYDh ZX[wҞ<^.Y-dpuv"Xlv'+BzƤSmIJ>s3ǽ½QM, kI[{UcpMNmN  }_ Rrxפ}uҺ?f6t7 Q}Eo¯$ gzEtJ xc>]7h)Lq$ ,΂F: R9 |s N=rN*6$}c|ҷJz=ť*RnjJu9֎AuJ VJf`h;:3ck^ݦj,2@^Nn-uU#[rVK%T&}Iu:U N+I)( NGaH7_YvFé %KBATdK;ghA]gEd[#e^N cLUUתU}%V_F.tnKgrSroZ=YAÒ2uWzLJG#VԢvӽ9cyֈ\Ɛbi!5RG]<Puo][>l{Mƃ'Fhq=o Bu]BJpujdy_ᤞnZ Rvp &c7: /D4a]xRz,QxfZG'l f2Iѹ*gF]a"E۝ 1n)au]k_R-[ĄrI^z=m2﬒Ix}5ym+ٶSmSb>^HMGH#Ha!8ⳬ]LKkJԵ&4_-CI D{譕EA=9 4:F$AfαQMu̸6-ԯ&C@+IIVY<+5˧ +Gq,Y P=R8:9}1F50݊q =+$Fk%kcUďkA1Re75t6m\2 -**HAy+|ŵU?hQ}hRJFP=c1\FX&vm#%F݇%pݼITAe.oA+lzUJwLA(Mŀ5 jJ毣[5e]lT\.iP0V2Y Hn`*s-. D<1s m9Z\m6E릱(+4,{!u7QHi5tUA Bd\%EiA[&85Ҹdۤtmh*6Q26mtL{e6㿵/s,{lYk"bEx[,gB:qHJˆ~tv*q?ZXl6{$&`0Ki&)N9W78V6׀ 87ĒI.K4AJWyLI #:+BOgNbɺ$xz˥6ҐNrۀg'te c@B.4:vݡW$ FKA|WMޗxtti7/);@fITCG! R 2^  Q^@\+c{Q]o' қcL9f]! }so9-E[@N4EgLu* (k5DH# q\#CDFz8XHp}I ?qcA=X/[;\R_mQ<}nٹq!7mRA>إÎTXZZo7=['RKhՋz7JZѮR~#WYtҶI+FJfn.v`fsp-jךbٴͮ#A3jX0P]KtA<VtE&CXXYD,zS_3UA)nH)@༏^]WRAge),6$c\+tetKPҡUy0[IuiJ҇%\Z.e׸Im|&QWyUh1M4:-:˝V.nzupf y]JJe Xk:H8B%EKsVl𩧙[p،Σ½UU+ bH@&alj8jn/@j@ {KPFadlǖmMmZ;RwT U/ej-IcD#C' NfEЭhm%X9Rޙa !Ae!CCP^ڈ pz,JIr۷QXs] A٦c*2=hGI6HYCLZs[eaj}-{ KK% puUzgB-W V8W-{o!RdȜҐ:-^@#]M:)jpBd*r#\{]\pZ vշH^pJ:FB {^跺9BJGhJpTD>:t=8H`Kptn+ZT@w7[qu8VTc ȋ}#ax{@'U+zz7I-tVPIP@PEzRAL#qxʷֽ]Icn)WJ<=S~%"(afk ppn4<AˆI3U-pjTBέ&峆ݒNjڬuzSQ%bXcMszU: ,7SOjXwafUQ 4JB /ӟEќdI i= ä.UޔhuS n*'MWC)Spu+E dn<޶[*i*%$6djE2IqIt zgQW--;rWUDouGQw SoR N~:-=HKs 5MPi >Q^wGjl>Mq`i㴲2  %%-s ; 7]ޥJ_B:OA6U[]%L\j"t[W~JIAĐp9u9Zƾd+R6Tel/ [)Rt[J)iw,LِRX+ҥ!`Etmкj\ҭ&ͅ߅PUGR 4zJ?ڐRwy۠Gz+fztRuӽ5K5נG.b7 r箪:=WUv"*;|ïV}:z;W6a&GVx)h26*F>ZX^&>`K52 rOΧ\J**ٺh)Ja.ҭmD:aw;_AL u8r4l{!Π;zbE3(GzQy5z'^EF^wX ]xW,bؼ|L*/-`7H7NqDf)JQҋ} TBC@5դ,v$ 'EcII {5.4UZ  qRrU7\}E\i vuOBIj`noO\u+=%؅( NMʕM\^{!ݺ:?t^zw[M,^?mZvH $$)}L7@dUK8kHz0%{X|wpS@fLm U*Wg\(PJ68zjB-ݺl"ߕxZ.VZV[HnDS =k;-Dc|U|P k|+F -]ʊV;*I:(Nl {KKnN)]6힮B:=JԳ 9r[ѕq`LG+?JR, 9c:; kx md/Uv:hfF3.-1 qT*VүtS+p]vt&xQl^raҞ*alL=5p6ߤ#mF,1E|[:2kJݢdLws'tm=EsX=:xo°HAC-AJ$¯c7.d[2E]ൠl edsnckC\TlI% `I$r4Ѓ*D0bC%ϥ+Qxt ǘ+gKB:U) :߶%g H܋,)}꾱IOH8|w5=Pi.} ڣD*åXvn hrj]_Nέ0Ish'tGT4D5$8 d k3ANDoNaL~\ skҭ$խ K+_ $}}]"RG?!?xsZ^,cz8.])ZL/ܐraVMd.#7sAh):Vgq7yAhHAHÀ)HQIp IIT}6xuʇ6ײGnĂGkgI~.wڹe ;t-\\^ ٕUNIRQt Po3:8M։px+I/]wdJD%-I ]P9ל*ZiRR{4}zoYԓ\+z:zNQcѭYPj n.MM[CvPR[7tAM࢕#˖GԓPHڂ6y*6֕j?inVإu=T$?M(U-iPK]  JI Q(7@ZJ;*}˝i+Y!}բݤ-`4MԯWf峜Ä* 8Z*(Jήu%=;H?X%}PֻXp- Xzotp j4HjFJ4GH`9Fmx#5U@pSޠ=. Jo f 3\:U rgt~尕DC+NAWp=FkT%i& EIs6A Go Wzq1sTaL _|+PW/U!78ךlB3]ޯVmj:yup\TbM*SXM )+JnP|ZTG3I*=2]qTnEhfT1*ƬQ*~w{"ծR\j?^oQԉ$ eWJ|FNb1PdGkCc|UtyA=3߀#W{VHRDkOGnQVYG \zrgcEJ%-+m)[mfa6L1 ZNRepYuz% @&kSVgk 0c empv(TNvf8FSUU`Me[/ Pl<5}8;ѭ-$JE/ "M&˴<7DSjUrԫLw(Urn drEzb-Y$)ZAqF fdZ `.su;TGUpZW:vly* ]Tz)MV%WeK3Z:7Ol otH\Xz#{4UUkPXaئ/)U\nM!J-%Y!.&!"(dކG:9d(H֗mI$qzVKӐ"$`n;QGXE(0Cj+HnH RĞGBBMf֖~w4&Vj!D x˿hl5Ob^%`nL6TrymWiMUT[^T$T wWN$/ʽ~-A( k{d+W'MzBQ[!܉ZtuB+,eK@U(h5a:A<춎0£1+%jm(F8>_I$-D2STgtZGEZ 2łĞm\^|]JFJ^O]7r,r`Ҽl[s ArK!8u*zP4nbҋ g*VjtWM= oyfk[oPMfxF$nG^ /REJAAW^!EBx$BSJ@=X }c~oۂ-º]ar+[Rk;)EE'p>+s5uD ^˩KhZ",TAݾ.k:oO)El$xgQt^2XHuXd䊺#Lf>"U1oG$Z~ټ)PKZB6 e͵6JR|[we77JZ2yq'Q+!Iybk#۾%IJ@)' W:类u=rB >d2qªOc UmH5Bq*t%ZR\vH@zg۴֔av+I Zw5z-= mKs_W]z\kR^nM~2Ք 9wX.} 0l-ob%hsM.&GK ihq\E5Ǟ5失 WmEi$f2z5-V%7-ﶰ~c5z]]]s)>MſN0 I]ΝzJIEǽc-XlJDO)j-4){uNĦ)5 #qpWP֞;2¼z?X\qzIęmґr Z;~F,C3(;vv:M&l$K: ФS{oz vGG{a-`N[ %!mr.PbAT"(Jzm$ϖbQx Qh"<"J#~$*VnHYZ]P]8N#q@ )EY|n\s)xT9So 5uU viզUt4誹fIy;zE,r\0~Mc%_,(BڷaA*Rh@V`HRhi:8XB KNk*!%4GxF=ZU:<;t\cEu>]-]'mnWV.gĄeNX'2V;{eJnֻ[:agez+LZ:j=u6}=RTH5;kxU)Ǒ;h=&EԡJ⹺%3] m˼ӊӀ-j^8F)b4x) iqc,$إUp} W\Dq`Bn/CWrJ`kokHryWB[H5$-'qVhahUUֻI -,=˖V5z3tΔRT:X;LUu]5$-AuZQ#K݈޵RUյztU\ ?tiބhUN~Z[6JW#bl"$ɢvߊ`dp!ĊrYjyRU齢dA H2ŕ⾑u:TGl7={ ClXW>C |[u1}:g؈!acRfؚfJmC#[ mZҾR+ #۶{>L(m!`ӆIyztcJ;@H+ś7] /JROWa.wZ\hI=gPe"iu -+[85*Vސo\҄:JC'+W(ض;’ ϖiub΄!01\WF'pqN_jҰňk*iP)uVY:w PUOd՜ B %8KFUUwrz" eiHxիt@0J>@JJ`>({xR)l`rN0\rPmaT<V=A$ VُNi&ECDyZ[]'P,N LBCݑf"Ubr:74sMZF`,R`oRn \piaI?ZЬjIAFIra5ӏUr:3\ i!U% 1*ߜOt:4n䂖٫>$t+S'`m}Tcu{ߠ7O=:'A_DA.eYze?W#ݑj^jH7qJ]5 a cB Qr_o]+\mWT.$| oJꮚ}V[:*; yZzE@%D\½o־m,yI>Wh"Hqj=k9\涙1 3 ˮGJLZ[a$vf)#ƣ[YBHYbxKwR0X3ʅH,K"6TmS-cx#Y~0p;Cm]W^] z@2 P|N q#(Rl7m!|*\7Җ5g *p!#*j\Ro_-1 jpY$m]XBW=,t[1 BhBTKg-ٳQ 5-ZJdF~JIh80B+L~턨9<bfa!upH,H5b6b/cbpkI=)RFs:ڸn%{,3ްz8'?-q)FUdUW^JW9-ԩ\Ast^b(AIrAqƻXmݣ-|]+[v*\/Z:9Ki2vg3 "}7 UZS=vw91[9ҙR]q[뎮[l(M’ZuO- mVkp`iKIZG!{5Gyr UVp BO5KGtAhGJUG:q@ۙ:3yiP8bJ-BԸA:[at*NS,ߋbjƹ Pb PnJtzqܘp8frL<}= QdNgOG̑~֗cTw[Gz+N_Ȋ xzǢ>5{RK<X Vynֻ\MdZB#Eg֛vEk_u86IHY&b^נ#tEn)=oS eI&3遚gJ_H+en.Nj՜tYQyhUQlu1T$icNBJ*K+Z.Y BB1%`Iԅ85]s0]MfHAPXJ%5W]t[A֊He]IB8W:JOMzB?mDQDgdrֽSr>'#4sMA΅QIcͣqʱ)HL-5:UޅzOJܹa QBNB 5Һ-e}uںIr$Ԇ-vg95B+#ixTyJXdbb׌9I!I'_ )Cdn͹aYl -rYKHVt<ט7gNM=z/ttb::VYe@5MGL UjB II W/@N:-[7Ju0=KrM*S:]ȽRJNmKvpdCX,A{ 3Z8-7z'GI[-MzkP1!#T"垆GGः[v}\P=!m1s ..6CKmL5b@}Є)ZJKn ns6z,;"WX6ԴlYw"SI*u$+8>꒶EVtGTJ߽Gnv=DS!=ynǩ^޼_V7{>@E|(NThE#s)7Bp˾"5w=uVXǢQs `F tz֝b_CqXo']I$}DxH%T4GNZyD%iUl<|5vnu$eE!jd}L|ZКL^oD݀T6G0L @T\JOHHXn ycEՅop[/&$$BgK|xR`$NG&&u)n> #0x!YmnhȐi*])+`=! JBt/9wϦUSykA0"7h^qZ %&ؠۡ1Z$*RS`Zgҵ%anVΘk.m$jf|n .![uzևGU(k$pE8LgMJ<I¥ZyқUbǸ;TXWHђ\$K]%OFt%;JB jzP@9W\ޱҬt~Ԥ($08g}H0iC8EuYqقpY 收0\Z*J) +Z7i ;:حK@M%6Kδ|_@t$e#Ztnk [r)D-rZkΣסhĒ>P\ އ;z0*x4-8(60ȕ*W VM :f04+ZnK,tkvHJ( *.J4pS RϹďD-@dt e"M cg?zsRw*ez 'HOubH to q Swsyv:] OҬ$q!ԨY=gPZTq,W=R#>;Kq\= a_H:_ZuB= mj$@ GTtJEڿ+ʕ7[R + klF9#)i8Rg{q۫4]/پt t 랭XѺdg?}%t)G|KS:"@wӈ?>CvX;s\)5{7,eג<DM3+An 7"R:G ^^Z@V*.mgJOĤ5:Ϭzg^ii'*AEġ]T$)0kJiפWAjBԟ#w{uwAiݛ. }qP@Ի7RQ0l E]nev q#rOl@:RCB+cA#wnt'^BĻB#*5Q?: 5IlpG=3M-Z#$D]4\}%v~@AIPK" n;Hn$87WѯXv4s,[$^kq 'Jʏn}/'Bj͐EI.$*RV\BuOF6 %IL-m.K 7VV҆gH@ۃ 7WV*%Nh^.Rfˈv"ƋgUP]n"A 86Jd-qzǣZoiKiﯙnhKQх$\P@y:ZJ]' s?[fb+kfĴ-s9PF;A2t2YÌT n;R]cuǺJR[]@ijԄJҀ̨߹'{Z/NEl4@j]G4N Yp2Za)$PW^nwPR.uΏ-%ٞ5ຟSb@ZĤ 8wR/꒔B8EƒD}I uuz%~v+XP|5:i JF~: hfiHcRPO l6_4t8&=!3/XB" mi#(:Mv:4tsiɶ a.v=] "Yyva̸.ҁJPdQeJx Hn%vnun /[IQYfg=Yq}6 (Uȷj/zsR[M vifʑl0])WfOђ7[9訚UDUUФ6LqyBI)qKV+$[)f*UY/)$$ջ[P7 LPtaw/kUdbVK߽nv=DQubt@:on{zwT6X}9U@L ""S*?HlwUnֻ\]Nk]t@sm]Ov\@k^BtJ32; 769|o( -u0;:# }j(JmaZڹ>CNh )7r**3ӻκZ[ng!YFIqPLVod;P`LTH$ ) "]!<\O^ڂPM4Y"DaȮnX] k-K+X^q҇iaq\GWeFBq-^aAvRHW)=-@ ^^>]U I?*N@1;J5FZRlw]JuC*S(nm0X) 20ґ+Hr-9W pT#k,o(F>ڙrwc\vv$ PcKK6c7hN WRj~V a?*ލj(8Ƽ%Ju 7Wm'६yy "5W4DǤU g7&l*R UԯCz2z8]\) $ րtzյ9*գNN/R_ij*ljwgHcՏe[61sHTv0DD͆"+!z܏sּNXƖBhծ TMm^$d%_OE_TmR9-ISjkVFv:X%)@ Ci`.q\#\uswɸӰrf=.C_}вp\է4]2/[Vv%L@|_zw!$1$7Lׯ7,u}vl9R/Y#ܒUH|GoBl56GFѱFxeG瑈%U/h UGn l!P#"s5="6a:°0F5HAZt"ިP7]Ttb}K,  |\2qUsF!'j+ JQiLnҳ^5{"Gi $:Ė}ַJRd_+nmZhr"nR UGiNE*h:\bq_KktljT-&iakufWI_Eڀ."aÚK-9#*7xG$@A;*8ƺtק/z϶$U Jĭ9ǪOH.t}PVP'xg~z",MTH=QcmݶJ**ug^}z.܋=0}t`N dUFINpV]H(DO2Uzf&w ¹UuS^EJOLmMӸ?9{ı480 !Wk=&Ҭimp:~^V'jUήWpo$*|W-اfVq"IZVG/7~xL*9~LC[>QYzWF_EXBTҤ)@FYN= ";.H ,L1] B-%@5t.`kM-$;})5muУ(f "[~:ԫ bb{+a6O,'ZTw_2~!f$ X!U@ ҐB@Ө15cč4sr>+ eclB wvB&@,TuHm)ٹp(e;S(8$͎4*XJВ;>@jjEݑn "Azv?NeD,*.n Ft:%AS%[.bTt"H7]e,408a[Kh+@I8-Uru)pwR,[W Y:-jQ'||zJPwKwqĀI]N#j+w‡ي_dB&u s5֓RpUUR:oIFġ"C|^UՔj 'K`[wZ%GLMsIRB)}X_!i[-:|hq,3b[(1=O^-e8DKڊ\媫zMJ0S@xEVG-u.;IZdWfI}`SE@M;uUUQb;gSA<9WE] vǗp:HZn- v,Ķ#ZGKDiD𵦠ma4$b*CiٵVtuwJS,0)} m[L>iEC-j;ʤ'VX.vV;)S6)W^+*$>II7 \}a!LshdK+bS ^oF=Umb. +y/嫣yN qPBn6G孼Ԇ[P%]JGCF^#uJTuR[F]83m..鋎 7Q Eӵl 7GW67IwY\TЧ`y   s m#Q{PiAD]uz8M눑ƺ,P_dW-BT?ƻC |5*'5ME{9wVa$R;S1ݳqm>տ'Qԫ09Ԃk{Ώ-zV3SfqR:۩08|]G&x* q Q.u^vk|]UBۮRC':oY)`Hjَ+}:lu$mDWb@#8j#b_G beu^[h= ZHޥJ?XWm #龗9W?~[j($ MU_niM$j}kR.%C8JKq%ҾbXo F&J4`NJTnl"-Q;Nx}jg'YRCb:RYƠwr۹nIdjBD|\/gb]W#{}m؍)iWbh?֨A;wWeimE+A(d]NWhl+B]RT;~;g  Nϐ :@%ZҢ$a*;}b'/4g`iG,3K숁q`p.*k)XLeIVQt(#AqK4j잏Ԣڷ-u2]p(9V0XJƤy,I @iQS{mZ!]fޠTUo9ݚҺRRҥ%(@BQliJR $א裬ouE=ii6z=ՐTJBJC*,@$K4Q$\~2zav* LRaWTAYR@=Rz()!@ywrXEEbq#]8`Y@J+Ҭ2[P pPϡnJVVJIm~ܥ#>SR-@$p\ܔ&-!̚)>5iJʎ!X:+v5mk m!}i%(B i\nĒJ 08#nY%s7bMpKqS TJ)z Hց'TW A"X9gct[MN>_5!WEVٸaMtFl29mofNيb FFHC%{ uk_-UJw՗,lRBA'%KgCR]D< ֢R[iR8WCU=HRPd8ϱA=i L;KHFҩ'HN W$QnH!sFM ԄIYD 'Jƣ ĵzNmHIQVrM[lp(FE ٱG T9w-ju)D<]>I D/;_KQK pj=(-NaKTƢo JV`#@3XT)W]T Ek$GαuGˋK! >IF`?Z`6b\T­d \TC&e)!%JeJ>~qS` ,dHRbUL_giElP[Tp=5غo ]{*! L 4 =*H$yA4Wjݡ:uUW @e{^~ʍ*J~t7HHJC@Γ,6K_}UGmP\hoBݴ_HO2OP-\Έ ЅS"攱,*D@*+:QkZ}]>D. -}kk\TYG.m/xËPeՠbehdҎ Uttf:^/еct  Cvo/S:꾗ъJʬ:Ӵ=čpڱ-=Q-X#Mxv#ms*X/ZCH1<l\Hԣ$N+DR\1ܡllJ3 M1*-$ Ȓ6!E5eڥ]taH>Jm┤363ʱt[:]! j\drR jvֲq=;StO4kM8.J􎨺J7XtKyWw%v|.7i]Uw?Z4:\jTqʠɘCRް*WWk2ތSqv_qDzO@Ԥm$$ƹ=%*H /SeF9Wj;_)a&:XqYzvH4Tjp,θ"M%)bР0 ~zܾmBG'fd4XʹВ(MMl:rh ;IFNA㸪q4􎐢Fȫ* z|1.ReČCCVco y&: Zdcuv&%[I,!pUuRiRvLX$a P gg\G<6Ά u>ʋEF>="]!b{g'F kWY.֝ jb|Ӌa* [,$HMr+tw2@-' C5޲C#w~kҭJ{Gy!T-HyԊb4\^ # lT-xfդz6׺81xª5Q$ʔ[QJ59w3iGJY_GR ( Ow@(E՝")R2w*l7F5I# Z q$=T[W^ȫ+]8+\P Q㺽/Fڶ(%ZI+/uz{+Mɱp԰w~,WOH ;D!xr豑vm;(*YLjh)~bJU\ָ)I9cVڙ 8!}4Z%lbOTQIpeNڍd89qElmŦ(RpvaJ*P\ b5p>r۪eVˎ$ƬCBV4'dNkgC(%$J"s蚯+˛G pFPr*U{z0Jxe Y MyRM6`w.W|(HP8j# nSmjV[JIB19;2{iK9vCh]I HK>Y@CpQFyiё]Jte+%K*`Ɂ[Is';:O(I4։\ * 'j#h](@&d+wJP(]Ө5(C%jtB, /_X:-$8TDn;\7oPmd>FtdZE|*:}%4r1{d(mvr_v%_DzzBbk y YM(5]q` lQ|4ƛ2Rw:Hz@6dIeB֢.A WT Y;nuhfNS1T'<(F[n:+O-69*oH(!20E֝_Y\@lyh'[ۼ:&r]~w>D%ChOj+ny+l>23YٽJqvvPRCz'KE;<+Ү*:FۃqwUtjҋ*Ιi{d)t8vtoMcOi9)W^ǥujC@oEe=][`I drk-]?h:u*#%/,1AӺJm(* NTl;ʿ2 Bbݻ$}Qjċj~D+OzJ`t U .R`? tE^HJ% ۵E (SUJv]1nB\C KQ.Cj}=ڐb#p1R@@nhv*R!j˺:I}j$ȧqoFBCMZ5(OН IROzB}"||ލЂ!B@aVSe@+(=<>fvԻQ<~TIXROδWL; ();ʶ!kEvU@H <7hi ÷KGz+ӽ5K5׮GNg|O,^G.iuh8?W*ZwsUz\{׮G@c= ӭ0 8wmHإ)$|lW ђm|W޴Rq}4tE(֒q1_DYubzOD- /F o쉟xn:a\ӭC. ]AS(}f1嚆 wJC@VfBic&ZFQcPVAJC?Es:cMsMW6s"&*64J` rV*B=; qI{ @Zd1qSgS;zZKZȜd4Uvu}V5$җ7!PgQ]JW] H*" a1\^J !CzQ6eƚEl1N63m!,T]VYZGUԩkfh6itfBGZs4UW\uV;/ 庴FjgY{U0k.v |0ծ$U69Dz'АZ3Aj3T˅\UڥGѴڈ%z)!CTP( v+ n-2\^޻HOc,1pVҞUUk@Ƽ8Ը`H991#tP(UU85T5{p{d2[B^kGVv؞kmBbCh g tLo q4ڥ[<jѺ"nXPdE UsA[;%n/-$]Br؞{$zoD60֐E]'b4AurM-!EA{`(-qҭ$Ÿ_UA |8s $bJb] rõN{"l;W=Bŕ[HA,sӗEHI}%[f<+=ŇuzuhSla]܂# si49 6*u1U*Vko[A %?k}jzei+V;6Rs"t.<+Їn;<۶:~NG^p# Vt $#4+mCQE*Vttn{TDo߾KJ]&ؑmnR,xkpFYPNalUh "@ҙFZ$21ŰsD,4)WLQHdps`^Z6(ZҢc$9P艴ǵZiʶQ^8*`v%GMm{MRd&[RAV\k e&HA-% ֏zBCKt[Kc#Z#D5eђ" a)N+O R_HQ*RJ: MNxv}Τ\T-ČWq}\ -VuDVCJ8CyٕXp«NJЭ)W!bp,䢻i=2ҵ:nIb<gGXZ$;X}0whkr'ԫ 0uqąB"OT{U6I9uUM[&YI+r;t.ڊ%HI ~<+uVOmq*(0RIW*]&F[]D~aRsXk\2U9e 5Yt 9bb cAJV@]iNҰwh]u+h1[/OI􀛥 7ZM1qA$z4qtivo% ̌P4v2RVX%B谖QQ-^ 6 eQA'H( HT%son5JKԫZbϒ Bwψ5#fb_*rR7lر! 3Fy:Z꫽nFjS1S]~Ӻ5oJU5@ ƽ-YVT u-]!jITay T89r :0 ;!pqɦQd.v>D)R֫ɵcJp,7ݾOB퉽/=Ǽ"ڐ `pmd]貐PEsyoyjadJut" `wZu*[ W1!6:ܞ- -+`PUjyR~εj->TL#| X@A$qδ)R#BiM-7 u.0oαH, 4mu珗uUΛl(#{+]Οj\(< l"8\vJ*T9ozk r.Niqʶ%ZAUW>.{;dPɨW rM~*uWWRjARϦKzlR l 2 rr IJ@OW=mVTFjŋ5*TGM=Vo%H)V#sݏQO#{3>kk@G.iuh8?W*ZwsUz\{׮G@c= ,PbmJ7,%@ J3[wC%cX)RK*r»r#ɾl*;8zލvvHr@}50b Fbʊ 3]q*=J%ZإJ.)*RI."#dH+ԕн*]`QnR@tnƘmaeLn÷"cb 0^fV-]X;#?.{+BI q?=s_DMԄ1@󧮎& A2*Ylcn}4ߔ PJ6'5 ]TG@K]kXvTdN%Ynڣ'A) ^.nv8ffE3KYkMHc4UGAD75*Uٙp3UVX"'#)3ZCsيV:6mւ^Yznm TGj,-;8 E<)ި"бLZcs[ 6V8S),zMY*׳)X*mi B,9:[+X АG:r/#A$nUJ I0TC`nRA+`A~dhOfyiKȫ1 m# tVipM-1e-: *(#eGR IQ- |)un|@Y. Aܶh{]J0<ʵ2e|e'mC]^`%D$XzmS+BXBC㉦"-tm/qhnKjLp*T(U䐗O2]ВJJI!d9v(g%LEP|v-W3b](kQ)OQ ʹ)IsB_ 0E"E-?X =9pX׆W V`jMJU*6UC**>ؚ+Wr)- 3 RJZg,afTrFݪdJ}ҭEp@^BR!Q Z{MKSS&Hpr)U݋ad0]]Ü sjIRڿ*Rp=ǔnkI8FK2WRn0;=c]d m"87?[UNGynWSpZ顷]d1R}#mNjUK껸6fBx7i.9e'!}e|[FpT$38jvR]AMۧ\!l[snKKi6-% z),RJ*QզQԂ7]txv޹ǨtfztRuӽ5K5נG.iux8?W*Z9sUz\{׮G@c= ,X6J+}z`$*T3WE~zj y p%BA[mHaHcfJU(†J.կz ޮ,&-fX ;* [Df"wjQ]R(&ըOXNŠTҠ8*At6tY%5ip&Vwל6;%q4hV,-J嵢ڛi:aY>B>C^{ 9RIϗz-vJL(54GFK!=_5Y-.Bb9\٭EдzBjZkHAMP*3id55Y eֈ`ƽ*}Do s1-88v&m&Ԟ{M+L rmV:Wcڥ*V;lpc|e zEQe'LNmڮV-q\4p'z3KI.8aRƪiM$AzBĎnѶm a'n[{vY {[Jޡ=jS&PPCƭQ`4 mi:vn"&0SZǴ1'+p)+\{GJ6BGPWCZI:{崍ҵЮ*l}/y⹝ J Z 龭V’ `yj jqCC4}f4* *R8Ҵulj1WRcJ i1UѕqI 跅Kz{M)"We(qOuk *K-#"ՕoAvs^ ƊTD='7pudz+J% s17IKcT s`@WwQ5Y~"86s ; H=U]z)HR 0jt1rປv\oذE2>^jԛZ y eU53խ$)Eeshڐ*+q)ՠ6Od9qG^=$\&z ͼLNHk_s|d7 vxq"8y$'{d+B*VwJBBĤgXϨY,] XIq.kѾ .\ U9Q fM]ޘnX`) MӸWƨZbJoR-\\'ߋB ԕ-P L~Z&5XAĹU`V<OJ㊐!n*R^s w>RdA¨n \:7nm;GR[ҥJcM-S{oRY v#b +ZZ'i_ {^}X7$y+ttK)*C'CXb*TRbŋRJhi GM*~w{";ٞ]?Գ]ztfztRuG.iuh8?W*Z9sUz[׮G@c= ,X6J+,XJ*T1厨Vjǖ͡Jt+}>ɵs2 x~ѮK 78A_B=au g, R]$`(xu}݊]CLVL+}6VysoW YҳIvиmCsi0@j7S14iQh,p"jaWHnX#rhjw+aDWm(Ud'wk֎rvܷx W&uv2 &$i|NMA .▧\ AŴPH~^ͤ)Q$6ޔc$9F8p#E`6 :*p1۹JZB4uHbm[J|?\?`GR {5hJȅnV|V}PjbE.7*$I9*S:r}EWK8ssӕu%=mJI}MԷzzJ:2UwzZ(M`% ŋ)R0TXb*TRbŊTRJ4zJ?ڐQզQԂk{Ώ;=\TYr:w=SfG.iuh8?W*Z9sUz\{׮?@c= V,X6J+,XJ*TXb*TRUu&<oZuZ:} ö~C\ UhJ(cXwAGLA˃ !* "088^-JU:JR{5d xTl[;fsU$LwJRRΑ)ye͐LiZHX:mRrtTZNst}*!(ck8<5jbPYYIT`L2D*MoVc/KmF[Dv-9jZ []aUR틛i+dsviH)X/Cvb@%ęOsYS!M,wu5Pkja,%a.> n]@?>-# |f{U$ yS%.\RHj_l"6x)]fU`4)Rg6 wkuS_ C0q8Pࡸ׷Zq%*IPb@ aU;EJ4 VeÓp;hAw׬oh:*B{ۑ5 `OU 8P-xQ\T*5qE[%wDV>j(. 3"~j  XN+=ގTNF4;]惎;f;DQ$.$xxUJ:T4@9wEZ (FzGCFP m$FX/t\ @纻 K0/ AR&2٦ u(pbv9|^wդҍpo^y@Ut:g@6o> IQaLe2D/KAmiܖG>FW0Z4yG3k M7)TCE!E0d9ǓK]%'xtCCQm"J\kBF|I;shkiK-6G 1$RT&ې@!&Y+!VVR$NϺVC}5.T] .s Hnm_!E/1J.K#FC>tVJ~q.@q}wP@RU*Xv8Q#7AHw>P۸TH N5.ܸo/R-AڢU+:z@-$nXP=$NYqgzZ9JwVQbں$j,gRP}5g*Sn@%#;Ij"(VRkTURJK0~j&Cˀ ZYEu(0X¯T=-qD MeTV𥮢0>*t$(RH (soURpË^Y^jp rynv<}2ՐAP+H}u6TW1ꃙ)Yl<Ep&d`7v`;W HL8~?%_YpX'< G`ٶH$_\ZGpEkFnvRۚ` 50e( Tzml%w.,l+WLG꘧w*]L>NۤUB!ОO5۬Xb*h]J,RJ*V,XJ*TXb*TRbŋRJhY G*~w{";ٞ]?Գ]ztfztRuG.m9#KB SG qkn430'X)v爪 JIT몽?A$u\:gtC)i$7s S{1qmk#Rѳp+d%H*hE8L=lt%HZR-RTDAj@" UMx= ,X_f8/SS?U5jV,XNq5;CWUMOTםXb;1^?U5?/S^vbŋS<z/TUMyڕm{;1^?U5Ln,8$TN54=c#p qL+zT:MCيoSY;Hkݫc(O4ƗEjiۻ#DC˻@)vhŊX5*%q^pbqUZ"YDt0{jH&!DI )l̊sj/җ%wJRNd!Q U},HP> wU&¾Њ$>-%)ӟiK.r>XF}Ui{qޓ~Kcu/~"p[uh6\Pu.岋kuWmwsg[饊yBbTgvR{EMiP9Cl!>(0xm-4>3΍}fzERbX/ TFÖ+Du~X,Ey^ :N8ȇRg{4D^&;;[`Kx JiجXJ̫(%N$Q=XRO`9ig7NZTLp dOॸgZ -p |)ZGW]k'?Z29QÖVVdJ](!2)ʱbŊUp*_4:£`+XTJ$9dҋ!&L\)](:R)N9+X/CX6dUף;H/ԫJRh; WM߼H* y`WGbL)WMdQ =:@EIߧ'Lj҅r@Ƨib+' 6:OZ\^E|o-{[VmX@e P eJŋ)RJ+,XJ*TXb*TRbŊTRJŋ)RJ+,XJ(y(jAFVGR U:<;t\cEr:w=SfOG.8|26XZ0FIux8?*oYm)%sUz\{=;QD^)]r0hq/W^iZmt֩,^v% bв1QhImp:'jAAѴZASiuU?Jŋ+֮5;4?UOj~ T+,Xq٧q~SN5ةXb5N<+'_SuU?Jŋ)\jvi\: v*V,XMjSO TUOkRbŊkWxWN5?~]1<`!x6HZ"bW t_- bg[ ~&>vw.hRY씢 SN_jΎ:"$$/z v[#0 sv,[5p>u/ݥ^C2O }$CXQuW.ۚm_IE&NR鞌ql;<#M EGf%&evaZ-"2S*}u~k#Uy{vAPLAП~꾔Jeg[Qoh[t;ɸ.*biA9X1x+t.itr;ˑ]]XZ)DySY/4aCN;EU>lFC{ YxR+Ρ-֮aDm \X`@E_2 rOeiMUJ ez{@hG*S!_vC:uJ1${M bQUԮPI7~3qI%kbz Q'T2IXJ¢XR݋{-ʁ"ͻ}ԇd&SCIb*HUVFūe6솶S*V,XJ*TXb*TRbŋRJ,RJ*V,XJ*TXb*TRbŋRJ,RJ*QզQԂ7]txv޹ǨtfztRuӽ5K5נ endstream endobj 1807 0 obj <>stream Adobed     '$''''$25552;;;;;;;;;;   ####''',,,   ####''',,,   ####''',,,""    q!1A"Qas234Sqr#BRCDbct $%&'()*56789:EFGHIJTUVWXYZdefghijuvwxyz q!1AQ"2aqr$3Bs5RSUbc #%&'()*46789:CDEFGHIJTVWXYZdefghijtuvwxyz?ΤJߡI$ `!U{ۆ5qI$afxS"+mc eW.۶i!yߜIn~xNf\ vv7.3w q78Y\FmqAIm"? vVK|ݷD#>}B%߃R8(&Gc?ΞņOMw?ZO.!. QN/3"_1+Ѓ ;ǽZU}snj{W2^iGR{$]qFl_doϨD{+~ }J\ڻw?wg۫jH/e)pdEq}>گI ˹=_Pws1cNnH;aؤ $GwrK">'3Ǧ$/'.'M[ B=r{t!$GwrK"?j3?lzkB}r{t#.'M[ BH9}w$t\$pJz=3-^ۦ+O>T6 oE-:.@΋8GE?VmKBv|y/zn_H)#irt_ܒӢ 迹#_hiTT/+n{wr*G>T>bP~FbAmNw{#mKBP#cS=@OaH #.A'j,\?#Gi?VGvꗢzϾ[۟'5#};$}2ڃ4i\Q/;};L>8(bz r:j'ri}̭z*F$vݥ!xݛqb0#9@Z~%[ ֜&3\SZU$,3ĥ僿x/?./M .>?N.>?,pO%e(M ;^wF zùHnaG;s$l/%w~,/%w~3} ԣGzKBiߏm(~={?e&ҡ\JGzKBiߏm*SF)Fؗ(.&䴨y0#f&RG!y>F7;գמhs hA" í09ͲI eHh5u *L<%iPa.U{A<%=T G ݎ#J @%H$\LcZwtZ"k^rO:^{ޝ|}c{ӹZCZ>!=aN>0'.g/ 0v|S·Wݻ}nw':2{s`7 e}q;P:Ďx^ww0?RQZmԻT~Db.\ St_b|G I[}h|=wZ\Omw|>a.%}KGI"迸&Gt#u1pG ݱ#g?x]֏Y5ۻ Ь78Շpvf{K\G:],t׶JZļgMrxV.X>aiGQ3ٛ 2;n1010#D|~{x[׾?%B.tRA%7X\/gbh/k8F{3{aWsc(J}-/ݟsKv~Kg]3Ħ"xWJi;.3yDThOddfe\8XL0$cfa?1G 0UJ7#qcNŽ˰2;uY8oP19In >ëx\~7 P[ lp;caidt aDIEur[6*q8*7ff<6RC=!Uf6!owܛ K߻KZ980'Nu6HϹ#L %3{mݬXnAqˇL6rZMB @s ΢fALvwj[Jݶyj{[#Zh *Z<.jy|$eӤl]Ctܮ݉cA E@ւjB|\tz7{wFxsa/tyʆ|6\hoD{dyKchMOnGtJBhG] ^}> U wY;YcL ۻX?Y CۏUƞCV=k|4`&Ln)w9W7Mzt "< Rs־Hz%־Hz-'V8߃P1hkZ 5LýZwX|ՠ$־Hz%־I673CL{+~}BDýZwX|ՠ$־Hz%%lcʨFl_dg‡"q=>zPv!ywX|թ˸<6`n|)ٛ& l?I"(\'d(͋9((7/E Ӄ}vZ]8>ݞn #d.ҏvHJ>ؾ߃R|R]>ݞnу}vZ?I"(\{|B8GI=Fw{Mݶ!yn8[CalVFVsQfw,/T6\ÏK.C#hiV/m}"j=f_n<T6! >|B8GI?V;=Z#w۷,/Vnm q6#YbuHC;vSo>;!JTTņ&9K<ٌ?ll5^pwt` f\M% w 2,ߌ!tw 15&ʧ )dOʲ'X 8W{I H} KϺqymob#Lv܏YcE  he"Z&/J~~7(86]?qK*n,!sF8S77#9G|7/QkV4h+/+ߓ۸iR0}iX=gÞlzr`כ,tܔgvd? *D￲nq $Kw$`כ_R^;웇\J'}p+$zX53%cvlpVFq>rPd? *G &ŝpI`baLQ$}*g%Y9;L$pQ #%(HzӾ^c#֝z$}*g%Y9;L$pQ #%!y{H|޶*@IJrwvI;:(4o(w/?֝zev{h}M$m".N΃ZD|;=7+}zݞ7_›z=znmM$m".N΃ZD|pQ·ܾIz^WMu)צѺܿRFfaЛxpz:Z{D#fwBP^.n7k1+Q{nyBIx#fk, urrjiqGtI6O@J8Vm{B}~m/{78@g7s1ij1.s`:a񱌋KݺݛvlFǬ0DA-.pă/I O{9MlbgR15aaŰœlPi~8w^Nܻrn0ݸ=ss^b./Gg&jΣ^hn{tpޣ]^v{ ܾV{/D\t;xn_+=I%P$I!BI$!BI$! $HB$I!BI'!Bù&IJ*!JTCij4IMD&nT8:BQ?I$+rTJ%$ISe &uI$BJO:wBs!EYn(<99Oq}/ܤI! eL(I$+"NBK$B+ۤf8❅QC!'JBdlT@b¹dHPBqcI!BI$!BI$! $HB$I!BI$!BHqȑmR4+/~iIBo\E*WI$)Q!Dq$$+I AohEJwd(? B^m^MOqLF|gv:stʑ:q:PLI! 誅`I$#E2I$BfTRU&yN 'BITc^!݃U5S]3K`Fu,|B8m'yϻ W.o.Өؔ2N2H#l! s+ptM٪k \Ť9 '-!2/M | ^)mBa$IBI$!BI$!I[S6^;=MkwN ݎa3D8l6'q17 PRw1Q&e59҉)^cI)Lbo0rɺīr,_;1XLgrZ̳qQU{(PĆFk1y8LQ0K$0u^-.$6Pɦ &TFA.^JpN)nLnv฼(q)v8 HxANRem-$tIM6qCspQCEXH]CW(V;ᙷK.@'Xn]p ۆ] LWbb.>;1<^et;{763.és:d!4MmY &VH)$HB4$N$UU`YH1ҝ+yGt;L*njcn?Kp9{N&k6~L8H{bS$-!V&ypT)q2VL|ROlЊǘ.9+#DTfU.Sc MGBI'$!XUu!A9I$kGqn8|/NFd\'8\u/:X9 8pyC0i+Q"=B8?@ff+qt,xFSΦCMM!xQsix=S֨BNM ɺQc=*Z aaCI;/ {(KnlbP6LI!BI$!BH7#cƳľ_йUo[(^{=c۷7RbvԀI-!$IB{&2.#1ywfo[?};/?}; Σ86w@GqVm:ΣK[z+^~x7w~bAyw ՊI-!$IB$kK>Hh̉-m9SvR{? t t=ظxC@-^`w~qw^.+8pI3%=e'@q]; D,cr @١i[M{ +J Ћ?e5EfpDnYPtN5~`ݘ-ÆE)t麰pWI-5@h+t kpn WW0`qMi{ڑl9ncP/Wɍ{2W9 >+bzTd!cbckFrSa澾eᇴA-IZ,9)&yNA!YlinT&.+ps*IY30ic\mם*k*X!WZMZ0džZ`i{)*'ZuD*P Fbtul4{I' DW PzT>6>bQI`0;H,Ef\w gTBRjtfBr817Kf/7{ݛ8=6&7N~a5y6iN2pNgH/-9@P7 p 4L*`oi22wIn Qҝ{[8Ă{e5jB$ȅqSjWsBNo[;2I'OPbAp>_֖HmQK$oSBٹyqGFCb? LsbTc ɤxvzFyzd`p mTॠL͕L(TdBs[,Xjq(vh6kװK ]fC1|RI8)C'[;"(E$%6Ocp/b($I L1`/qUw w.4L;RۣؤEI]GtnbOI KCߔ_!%ěN$z#28y8 (^.wQ3h<y-0w8k2`Qh&+|Fb qk {RvQo F нۤ\) )W V@h8?Di SP/ ̖h춇ϡÁ%Tk[Bg``2:fݻ,  %}Z MwVx;5\ZpvúšJ0M{{ YTG8KX쮍lsg!Ɨ޹Jd0Pg(B_ puI+ލff>`f1"\h.gpng~D6`y]on+wFy{&L]i;P\Jc~R{;e +>Ѵ UI%1쎩͈tvHI[= /̵pshͪ"@&O#E:~1/l$v1mML:,;k'6AM)dkBL8R{0jN O[`09&OMӎk^]:A? @'fS!643ӧqbPI8 0qOƙWU.9?-+&H3_dXZܭhC!Z*ilajl1&Eպ]჊p1V%g.8Bc#N[' t]N D% cCh.,+6`CRN9̏k@Jz7ٻsGrD;,pÉ5Imv.$ t.ys`5 j;7{pp .-\-ɝ F QHpiTAW:+nnFٱ^}72kI+۳sa=6!z;C߄ dC[V MH:aţH,Bbb(ұ;C 5gbC w3pWcEn}ѹq}kkpsa'#Vɯ- FҀqZjF}!tuiubĂhЎxG}60 ̴ AO3u01=#} QfB &k-H/ v1@E< .bxvSwE#QqBNV1b6XY28kj3Ṙ9PI$!kjW5ZS`APj2!y۵ٙsJ,V ͦn {5-x1y\..l1,} oP) gNSc",t^cVxsIJԜu'c-*&OT!KqA@432Uj IH"Q3vP \<^d B yԯt{;>I7I$ B;=Mh7/.U}bvԽض?ݻs{u $KEd!$IB{&2.#1ywfo[?};/?}; Σ86w@GqVm:ΣK[z+^~x7w~bAyw ՊJQ-ṫzYzBS|wX[kV^le^Ef7\7Hh9Ic.E;'.#7kw nZ|7pf:,[K0]'"n@ctnFg1{(d\F5ԛJ3c2]%C#Rsβ;<9CP5аah`$hh+sqqA4 ߻F\6~ 5 :E" 5&}ש"(fKm#,Z1>hfUC,h-vQs-ncÜf@o8n Dž [!efc=xNjm[Gp荠Gtl.HU˒d6hU,JtI+I%.@PHn, ާt✒z d9hqvohY54r-ѺZ぀ ԓ#A7\mK;N jT$ԤdΣ}Fy ۠v*-5]4ahmkJ-)4̘3&((DSR2c[NuʯKR x] FK^bvtnэp015-ua.-6gBH1GhkFU*sk!8juЄհۊ$EVщp9YO/N7^~0[`LNT6sKENe/vB 4V6lK7з wFܘ|&;meč9n|&eٍ Qi"+hti=:L%殶(Bb{2WV&CΘn~uwn)hq;/e04H"#hCfd~K[qu 5NQól!B --d|fk!ؘYKm"v'uob 2vVNs&$g 4/kkQ YyVE`$JK=:5 s*ݟH`@ FPٚ[!;nyviZ9V{vkhCI.KI7T_FYЍl,6膮V6^$/vHp9-=H譐"s&Ssbnl2_ s٨5ZsLvɣq>ڼ\]NRZO=) v32|ABv\ [$ts۩<)K($u E< 1AMb+Tbs-hnpT!t;9x8尘Et590Hԁ]ܾ?;{L[q$3wh~]x'+%ĉӵs#CCt1cWeN9]Ъ:7mQ2%G3iN}!{X۷v6xd456MwmѸsCyD8e5h;ex[v20[a5&ݙKn\1]3ɤ8E!՝ <־BeZ8= ^1@:+ä5ɼBhZH7\V;.&xkអ!z[N3ծ4=O|t,h{Zג25ڹbG=KMxt&?0qZqp_c`AP*AilH%P:"Emcc|Bv mv PG;8a7ỊB I|}Ïo8Tn3!3M^V]υ6\p1@h&[n^Y9KG/Te9@q諓DF8aUܚ)]t*8ZuM`b7 ]$Nx;{c0?賣FWEwQZ2=ԓѫJ)b m !Aͤ /Ktn<]:׃1]DҜPh>1^T:)|pĬdI)v`uKU[L;Z*yZhn. 8dl#1!3n.sf3Xܘxl^Inlkgt<i>w+W ,Ԑ6ڋcYEٮt{ae ƌes5'h}E0B|ƜF1Pt?v<6b>gH8Lbsɨ.|@^/{1s0Z {ɂ+ysyĢKinZkG4D3J+ld%V@,)aҼZ݋lj{$+ZIuJ1>a᧢?=m9ZفzfSX&Υk\ SWB9I EsNI%-IF]{K[@6Tav-yS o8wAw'13&q[:h*/̯9VxGk3Hqֽ|m\[8 !],KgkP 5ܯ-V:Zir@\KS\ht2rk+C/p;Bwu i[h'  hFӠ7Spqp#b&hQqvIh;AQ(Bd{miskpfD41p"hv,OlK r^3tj ;%r$pevjS:Χs,Fͺf\0k0*6꫺w&$9qcčhV;taQtu ]s3SuQ|i/dʸlkdg0շ1][66!8fO;̕9\8O uqYL7T Ts.|ۋ4 Aumj*~vidXCVx@a\Xj9Ŋg2azkџbf錣I-΃dɑCWuPG>*ޜw}b<4poN/X8 T7JSa30j HT)Qh4 Wq30 䵞pn!4g1^n7 3^Al8A6Lu*9BnTA a>W:gm+p7GA9L'BmlŰZbR $Z$(2gФFBGasEou =فqhZo p2o>£D9JPͭ""h<IjvdPE:,v>j0+ƫ{C2P@o07۠$|e1o{;ovde5ޅ-2=Qv8yע{non/9]pݺ3sX۟ Ih! $HB#1ywɌ˽@Y1:*廡zۓ>[߭^ۓ>[߭^ΣZ8H6(֎ zs K;Γޕ߯/z<{}~g^^x_ϹQn [ Uwu n;Bh;>1;].ͺH 7ŢGyLI`!*@E^Ve/'+vX A3dBq ZS̗` 4t.D]#H,-%E]nAskE^WAk]F tkT"feB|t[30 1 a.313@<%M-$vR; 8iyN%Z+s#$q9(uMyJ̭kX2\js\d]L P3n$`֊ zdD0IqD^Fs 5BM{0W{퀍d $1^L2I]š/q8xU‘4„B[8P3=F4]V0֒Ѱ$Ct +ޜnwbd=.qc=ج!k8TnS+6CO9] %9NQ5[u[hnF&t3*evUY( 16F*VhFM/J |V!B#KGaUdf'K_.t,F#,`c`fu$(Z[&"y-. \HhD`CQFF/k]eNns8_{&uD4LYӉ5$N]T'[00gfbITfߌwMӌWnM7C<=͉ `.7֍vFV ՎtbӓYs6'J=aH{٢C]z.γ݋qGo*+Us[poI?/s۳zqw[9Av5-&a+g3r5ptM͋ۧunV`589fF10& wsc|Xq3 ،]n+KKuɡp@ȑN[7%+5#"`p=45w%F6a?m JKs|r7;wKS /.46hݛ{x\/8hWu>:}v0_ٛ(v9NDy*r7.l6N`cEvegkG7M{,a&^Pj)ރ:3s:B5=h4E= QpRXNkf;$ p=gV#_#s3K[VHa;זNn,8wuW1q0o#F:N ep5|dsBKdQy-dHBm9mVJ.1v-)Q8_THy(9bݵ_hXE]>U ڦH+,XEZ.ex^z'6+m a5aInee6]jPo!uMnk_rg2ر&\7XfEv[wu!5i!zwvf#- \G:div\HrmVVZӓPp[2;Q]`WEiFps Ƕ $qqw&+x7DM|w.nA WՄַpN . 8n'GTv ¸!#",Íg*FfvIZֽ Wg;t_f>'D m xdɉiЋךWؼ+G=B#qOJ#_MVlPgilY[iۺ66Ln!q'΄*1-X[Bx(;2,onR۵`Fe65H95B{0vzb# ØF*qd#! }$ܥJ&n*DP ]Ķ|#W`L{8ois\>/LN}uz|LP d; ih{I(sH2CÄu%b8 3[a:Lj2moeAv(6cYX*bXu"F1~۳ۑ9ߟ sQ'cr۷g"I$V^I$!PɌ˽@Fq\cf5RK1}8!cjDUÜ1uK+L.-/dw.W-*-^20188Ht{K6}wA¦ܣ ْޜ!|L,1nMwGJ9Xhȁ7V_J0.t z/own~#pۈܞ6q@qhrϹ86.HOfU\\-%ƃY 2HBu\" Y(]LCqX+LB3^s9xBl8C=I3%F76yA ZEWwnf^1qM/PHeݎmb(LTEk92䑦HZgBpc]4v;scˆhËqE'L5#fͺ9[ eL'1& ZgAO үNx-G.6981գg$ֶ4iJ۝4KkvSrŗ3֢>>+$vJ^KI I:`a1`o q8d|ҤiE{+ilvL{)L*.ZY;riey=YE޻i*k#"KD9pq6Ya'F\6C@.H1mB86\(`HD]sI71\F )"iuj]NVe[DdnYu;`Et=Hcp .ta qp`I*&3sޝӻqۇH9Z kRh hj}keعg @gu^]q׻ d2H\f`6S"1;mA eKM1䲼#ElƷ,6G=@iO`V)-˹K&ל>.`(3'݉{,bN/wR܎O$ji#-՗unp\]XCr7 wy1_+>y8H/1Rs.B$ēQX#>:Vs+7 S&|}ߺwECh6q|\L|Lx7h{h!Kii2$ϼ[׹a<#1H+[p@s"ܠ6Z=%zM,6s\"EH=\nHŨ&ALXE!mu(Get`H/cXX|7vGf t|rˎӸBhW)8ٽS7 NICK v}kƎf͝'ZZÉs wt DGזFD2XM'Yf,7Wok$5AV?8 &Kd ziUm׃pVK0\ 1[5|f7 }Z ɻ0 9I҉b8MـڰzE|v[a~w2Wk0]ԑ$1ٿhf{4&&+ {KlVȘ^rh$dPѝ/\R=͸Y@4>! aq"-Fh8\uhW[fœ'1M"ep=PVAۭᇌ&8zap9O kN WYc|G Z)X.fJ d!wi{LzWWkNy5Fi yjƞnt)̒r)C(Z1Ң \']9Ճ(|18&_ T'- i=Y `8 y#R s;c #6c1j aT{yEJwy-w۩kC йqai8== kxeՠ$\ s`|i$fW\f"0NkvFZ$ŗtJ s3VV{8 "5"5LՎ1(kF+P Ѻ+9hhy$Dl<-7:J*j(uLYkC.4Bf#ZW1ߑsaMJ7whye&aAXl[CIp1 sA O˒Aqp8b%kjn7Ơ5Ae ܌[q\3$Yׯw>>#7>n8٩q6H M$ Ƙntfh{phd /nf;Cτn@0] \aal"yWKểWr c`)#V66 t7nci$sqsn< ɀt\No$zvU^7;( o)hJEāU8  .9"# Փd~e{ E $4qġ#R JnblFr^䙆-$~:]vmܦ7^xcc6g 9 υXmbظ|G_(:vRۍu;|w{_"L,k٤4dsmcN.t h $VCĵc핇2@TnSuCƏmpBHw nlW|!٧)0fծqi/Mqmm,̀簜2*&.ܡ7{^##KR:Pa{V5Bv nƙRvI9AShfO5CĪ4q`‹]0K ̂Ztqi31`M@}p[Xf 2־6M z &.Xs\LS\>>3nX UHG@,COe'?) X 'Ӆ:A;KG R~-=w6;w&)vV d9ݥ|2ab49ik !Pw{q9n6.[pkN+{E[7V;oS]/oݻǻsavDZؑ]+#Xm I25C"LEF-u% qc Oa K)Ȗzh/DYfG3ICCd/; n枖+3pw;rbgGY4<%sIw׆`; X\\ӊ!m/nwXVnZj6l2P M5WgCg &KDo vmЉΈAӬV4ղF* LjD/f Uo(Pj!yN[NnwKNWB-2 Y] /;N„),5 3(p<0!Zh@2eW'(jlVZIM3lU'pn v^ƌfcT$jY] *ȤY(EPؚA5}m$4fU uj;x-w>̨kl"-EB1 "vK]w@%\EDR.i0NXs? $q%8f #HyU^ T UHpBn l<@C;ώ+Q&n | Ѵ^#@ev*\-R(T{h6pm{[bhBQ!9 \d`082C'6dѸ4ԥ!$]B)0n pUo`؅m܎8aw\k0hޝ SR5Mn(b1 W6qr#kX%pK0t_tc|L@K^N5NhCLE)g j1Π+ngxdn)3٨W+#5@-DSF6|[TE`R.ULk7LK{ૂ쎙;!2}!۽Q'B417qݻۍWI$BI$!B5e҂dÙv؝L>;뗓{wFJ~:/aܾ^@ΫO-o$"a)wr{wwjNz V7w`Xq~„ƒ M5TܦݲUשSY@ȞrmZ0@ÆLAj/7vcbn|f$y[tcX%\&n hTqPR;6!&b{)^n<#dݴ NzIBgqH=f$UE; !ǡK0Zg@9S:cc&&B2dpq^!ܺ69ՓB@Q p fP].|@:mnf;oG| 8 xn!h,spwh a./_:kQ(t p qr?$B9ѹ31{4!_vbaa q;da<'c8˞a<+^v@i]Ck˟Z7^)1^T%꺵ʑҽ®>d!;r؇Ȁ v|xx{7I,hiAy;v\}a^~.#pFcDdfq@B #=5eL-[h&ܮiŭf[tMܸݻ"36h\?)ﱓ+n"h9,:2&Vs%sE)1#_vr2bPv_4/w^7.6;xn݆#$ >b g _!5?}nl&n33Qh xPB[1^FG8<1ld5qy=5;18Xx$=M;Mїs<|,| ǿ L<5'l/K|}q.o8Kpò$Mӛq5p{Csq`iZmԦw88&IZ@{+ۥ3ipBw5e8ɛ0{[vM(NPXOh唸5&P4e(i kHN`DqM C;f@sV5n=za|\"7&6 pp@#eDA3Taq22>a߹ÆkK1Lfs4A>sp;3gQ0Si^0[ jeip&U* @)ZZ[{nE+uf}V/ثnG?nGg֐xƢ =a1]Ik;4 LVs.WwLMŊ<[G2͖ߤZSFPЊsՋkå9+LU6i焖m KAK* {Y,lSHM*b*NԤSP#0N$$lϞS ݪp*H-!(nB!QD.dJRvWh: 2JZbb 3A0 g4զ;u^n6q1mhơy#sj"6CV˞C"rRZ +ʃڜo@p E)~[zἴt": 7}r|sx6&њ{Zhvaǰ,43иDr{ ԡ=)RRqNP@|)yxt弮u; y{-&$|R7'rT)*/Aa5eBW4A2[常 0N@=f,Y˨yEq9Qg#=݆0K嶠h^`v )vÃ<ĜRqB7.&`'J~&kÚ|ߋC$ 'u<j u.ۢʠK˷Žgfc;੉ag|{LW)-w)w;A`݇ۓQ11p|+ TM˾ۘD{AܪI$V]I$!BXs/((N,9oJ ɾ=Px㺌y?}noX'ﺍ5ήa8d.=5]#kq7Gs>r]ܦuzO/AL4w50L_|twS3)j"uA 60]nf^ỤhGvEd;vkZ@ ǘ!'z״l|W> IpďB$\ P4iƬ)]Ǭo]N`L4@wX/ x;0bg^ԒZ6Rx**ũanv ЅL[;o|vm?hcULnA)Ѫ7);븦Onp8y UI%Є$I!BdÙ~AFqq̻zPVMNugu轇s{ zy?}noXή·ɓ` &U.\f8yaax߯>;,<"lg}^|{06vudVid1(v]c2ғp9¥&5GK 4Ng 7ZaHV_1&H¦j8,@ns6gpy4@p#9!L.g*+|#ZnW>Y\yfŠ"r,XtAAh%i: t!z1`|&QW9S6uA= Ńԗ0nJDCdT7P9·! ~`E\@ZΧiUx]XXvv&j8:}얙,sijN|.KEn XخZcȖ; (aA^^&>sbAc!jFnI0AFmWwa|h9E(k\U1p^ ,@MԵ(?F4)-B@b@֜E7UgɒJxw%G6+/ܘA.k.Zn`/Mzqpp1$PvZ.V!iLi!Z\Vnۧ4QKևEJɒq /upi'{|1I߽{xs<2F)րEDRxg2Xx4.TsG.Q4KzR%킕cp8McLt0N( ]Dd35jEtuVXX8C ͻshڏG#,ɋM o WuXm,|.9qT-Lmi5v*:L hkrYQf10 (,\ii[nWbIep:phUsNv>R4D) tYUv=%ZK bJ J>#[&̙Vk7@aie<#rI,`b6(F#0 a4C&6Up5a27ʹ)ZeSaF7״+sam⧤V;؛پ8;u7sc9 ,pL 4XoVpsDwfwvo::n!ݕY%j[+@ڴAQ Z?BˎLl 8Xخ\ 4-"WRFb6iS$I! B$@$<ծڜBz`u :KN&}Ch `*WX|wm{q12br vtO'@d&zɽ N&6)"v#@hJ`8pGYD`ҦRӻ0ߘ3wHTƩtX]6ba|>#$ӈ2tkBK7Vy@0lڮOۻw>nq49$m6vd+]6@s\7I8sn-ĮLum@;8PTtw3w<s1^W9N"M僆cCh%Ğbme|usnasЈҤX++hvMJCN, VkGNUaɵN>V#؍0*ٛ lp.5F6#4̍Nvt ՛N1mݭmbU8b)Pkvd0L.}tlxHlCRZȊ0rs!xA98h ,b6/+w+'/gzp xv k.#lMW(s F}i[8"ABe0HY׌6,bFe,)ώwv.''@/wv@hnQ|eA; c&~͈K 50 T)4ҎZV JNᩰ,7C!v$58` AmM9L9ZD1-rC0݊~a4 s@ihHcrC̠S2SHJ뒥 ]׌7 , ]f:O2K|7W;cNZD ֐FF2)Xl $!7o 8ܦoxܑ^j/$uOqey31!noO0ݵl[QE(ޮI-!$IBk'˷ 5e҂obu0T8;^OE=uk7=+轇s{ zΫqvc~TVVUq9x^X}X}s9w߼y0ڛ#2U$8Qkp}gp@kn+ۆ̟M(˵@Z!ԫh3f\6RX+~Sc8: (8f֋EZ}jyjUUfMˉ½M =aNb$/<Зnix‘ÊDsk̽vݎss1.sA)hes&q jPӬ;\ ϝ E.ΥJ7rX5f6 ۙy|&; &Cz{ź0FHsnAtaãMlBphm !eƹTPPϳ tqk(4k+qf6l7]F>a3uպd =φ}l7& $;F+i#vpy͉rˆrH>fDmSdꋲrZ8̩&h0\*.;;ˈ=9ZOJy p [s|cXncx;4S{+ޗnL2=, <+MdJrgEchk\@PMsnBotvCbL v>|h,'~>e,+1ZW7>.w}kZT&ISc,]! q iijt8۹8Q,bJݍ~#,Cw$ -x[@nwAā M`XY 5J%aE" &+++^(xۛsL9xxt l&RQ4ܸl P38"LAMca w!px 3A$ OJ[Z=7K\ (9^pq{FFX:mnn0x 4^8<7:ĶySx#unWf"]xgf 妨OfS4Ej\!\W *B_a̤X ό0x"AA7336@[@̸;w`"0ߌ*6Za5Q!h8R.݂0"9Z`d B[L)a#0.h&n n4wI9I/1Wpݺw&;[>E11Җy K'%ƙֽuL-T u^̷:@/(nf =с[/q 2ВwٺY13UVp+d*1z[ѺNskNbj 0e?IE9skn+#s ȟXnc7(d4H=5. a$Xec00&&0-)3eh&T_N.L|mryhqlwP^F;t3@q 7)&mz۹Hm p¦Pz;rsa8) q94i`zY>n6 M߿l"C߹sw=.dӭVfSjʱIIcj3Շ R-eW_n $aADUzۋ C0oQн/{1HnLaV%' 7^d8OeŃnV.?hvT¸צYb}FUG- CZqp8a`n^SDbaI8[ Ɓ,'JzhUX"$;(RB$iyƷW--$4I'Yl Zn5!Jssng Z[BVab5k:I=2@=k 5uض].͖Le2kUf[>b*)]n. <2iν<-,>uMW97۷ F(hXnj[}7 7.3V8&6 Lg%ɐ1Zc00 +]fe{EW1$bIttf6Id3L'ZhM=£t!a !HScN3ImK?1Y/ν=g ͜{#6^KLAbCBuYItq9v7tm:9tW'L$RRB߁1@@2lp3Bv]f7YPb5׺f07M oYZ%HD:5v>FN 9 uRXɸ pHu9HO ,lf9bn|s3Xn'aYcn}pźћ7 BAMq%ـ*=l^v!>9qI)e2@Z5W['YGi8䗴4kBzE 0dOy5$i;VOXZwN`6y4l]>:Lڷc_a/֖Uv9 1fJoxvSFU.Q'Y\Շ{۳Vh0lTl]N'8 <ZB\lLa`ւzZ%Jj# ܤ 4[hytP%)@.WK$5= mYߋbn}ÇF;H9Kb\$YWcscaE`ױν]ټ[|G w6^Zu ŽƹZʙ\V!3Z6 -2D+4qMcjqqT$ MV`4d^PBչ79iEE`jk2lOYpZ`3[.fffyμMψ1;R+DYRe9ѾMLWy+pٟm67,%wap'9B‚q)H9Qۼ FnP.?tzǹ0KevՎ%w){ 4sHĪ5q9yl\+u? Xm^M1\g0K *g3 Ґ/Г% MBφXi/Y $I %"!7o|o7o< ߍT䎻;2oP-=|gwwmݞBI$BI$!B-!gE9hG[;wQ//㢦nӫpd9 BV^oG#wyA3ި ΢a](Hyo'/ޖ+{.y;O~8Hcr=8x{v D`^LJhCVyLq֊Z.sn8ѻ@|zdu"}5Q7fP 's\&E{ }#) sR9vn?6\M=sFh)Lڤ J4 !z8NnbA=N!syg+ +ut-' 4&;a3KyhE-w.!NJC{/e X<0;^&cAL8o7"Gx&YrGa{񪘼g~lN{)][z:wgۙ.:Hbӻ=I-!$IB[/3qE9hG[;wQ//BoTw{P{zL䷪;΢a](Hp>( 4brK?=~']?Yڽen`ۼq8Ʈǟ+Z:@Sk('^nh{LJ;"+]B&  (UZ^+ůKs24.-FRH#6Ɍqƥ  [v'J@HofnFn 3+L@B&0`I|Rz4厌JBMeP̊0J\c\GJ'rⴸ4w/ A'Uc1C9.qlՏIJBz C'H\)lR=[LäAT $&Zye%b7f{=HU(=w&kcOZM쾚 d&1"]J[vd'unR >IFء Ϲ7&+lt<ʛ 1];A;3v&IBrHλ̳3DFtTl Lf9nŒ :LpΡ 1ws7 b\^8ձ5m9h8|VL~"t:v6siikr26E3-ɢ:5Ic"h'Up~buaڬ9!0H0،fbvRb3CO$NV8hK]eҷ1g>V8$kn{cp5ƺV×7k׭Ke։ZI-aExuau^;|J ͵B.x\q@{v9<|s[ vi1EMlxrFIVT9ARaKCG64ZbK٥z ;s\,G0@pi.^?tdIc eigRJY&Hh9XeJjGʃ% ps9<>t!emwF.;0%w/ `dk[h"ѽظX[p y- ]fa -:Ւ&y ^ڐGn斐\dBJѮ|R/Sv#riRKn78:+BO,:R;t7t1{#AML,GJoFnܖl|MB99W:FrFrX/_Nd{7$wkY1\b%8| $]xk #bĝql4@8g4p-nٙcNq::Cq7sCDPG&L+"ĺCzKs屲W#]SIAPxn>7y\ݺF.!!h<5^c?qaq&籯iy-'mccNuY̎|5hƌ̨9`]y]Xam6un 6(w%%`/Sy0qL_^t6lς00I8Ptzw?8| ăr/^uX$!TQ"Jp;ٜLRزFW`WHethy84KtjoH ڸ4bR)Bw4tW;9ܕ~;pK.0#y1rb6[%Ο$kݧal0pYcrGa{<^H볿jܭ^f-; ^NFmlvQ`BI$BI$!B-B8x᜴#x;뗗{P{zL䷪;轄n(=н&r[ΣP1N2mq19X^Y}.]w?}GԽ%bqw$Z+/IB)਄RfW0H{RoLHB\3FN QhEzH1HUH/ *M(BH3T3p~a8AuG1!6@4y цe6;GpF%@EBlyyE <2;HQ?j<%a GBCtykOe<-$\(]e=,֣i|j! ՅKbgnAǰ(!斋V6U 7dpTǸۛt1ǒX*Ӱy6ix|ddPv@p0p6*yXdЌWuN.\#lXucYsuv.۷s4D@zN1еsMi#9iZ 925/Vy!hxqw Vn 1;-! {wuk+ n[Ӏ74mYyoc>h[<ah4*e|sc:{hAT4V:VQ۔1іCq$\I^kh@V[`nqn +n,q,FWۺ#[Y E$ec*Ռ e"#qVϽ \J(pn&6KIi1lkm11w@kKp1($Y;J7u|7 69$`67~V0,B KLIIVULa]Ь+K@\ O"Gbݲ]F.!8BkIKݘs_J<6xvfw&L9@w;ǿ8cÚ`!Eg/h23ț\ܠ#&NL20¦ kLHBv Xnn#c~5lj1}h.vi-%0CN({.{Donnss!٢$f*Qp<5U[œe@ 1Quվ{FnpYmc ͫĮ^u{ @4 mb#)&7\Z+I5j*jfB799v S,,q0q'W>&Re stі8F.(q%`0e X3ʑe;*rbn(~s5#Fڜ߹s="- n9ō7J{[ψbtURJAG(P=i %8.."iMp=0,R5̤(oᜄ!#N$N<{ڼR-X p̸ekaZr@uSg.§]h3@H0eԺMf WEtPۧ,آnfַB <,#H59X/3ݍZ/1$Eons΀̒vԞ~9ߎ_sv7cx}׍y}@ ;&Uiܬp&pm57 U*řcJπ:l٣U~3qƇ?" :&! S\n\7`O}ȱ G p*V d8FEu!7{0b!mM?0pX@F'+N/ҫ~9~3."jٰwnم$ng6u6Eg5c Y6Y˭Qp*C%,$хQۯ]67¦u-1 Bۛng5ԁBn{ ܻL6O&u0vl}p=]6.v츲cʸ!SVQ6 1T"*Bw!:+afhI<ݘۧw!΀@MWS{t؝{w)IƁ Y9CwiZ^Cޒr g`sA^Hq)j 4J}o3 <^O+_mнUoO6AI$B$I! P"x᜴#-B8?=Px㺍yKzߎF g%Q@ΣP1N2mq19X^Y}.]w?}GԽ%bqw$Z+/IBJ@ 'ԱqUS &N xgqf "FŎ&"IP$4>!4AN.7#Dܢ/ Zj!S2 .|q sQѴ X֋ݸ qgQ̌^蝒T{~0/L5'p.{ c$DO/hj9݊rk\9U\X$R "7bZoԄ/n,.)ƖW8o>& &tdRb6Qv؛ "F8|ק72wn1,9*ͦ8`4<:v#z$tȩ_ 91+vCB.-(Bw&ݸ[9@,yM`f͆n!iqM<8۔>F1{07֌\[nn6I!SS(Ţ -Y78x(nŠMId\~ci"yub`A5~pE-l\F 73i:oELM-8jͨlѝ Ocxj+g_ \ N`n[ۄC-U b m1:#Mi. q ^`:8<.t adAHnv.Hnuv< YA:AC-.2sK-mYh0٧HCI$Sk/as-w1g '3 LXL,Vaaa5{Ah"KA1;JrnLq` -wX8{|f?c9sDi]6M<7?'V5+Z9F\@q .q"g3E֚֕ (UmiB.W;6Z@H+I~n+scDLhm;Wgs 97Fr815$̸սۜ9ÎkH0L6|"5Ŝem9#c@ :\hAIMǹ1h7^[hW4;˿./c1I?t_"n]f6 s1n}|Mb4MSX AykB-P(K){D̑~n% p@$^;252\H&o3tl&I3}jr8W2wB؅I'YJ<$Ǘ@C�Bscb%KQKvUpw?+Zg11 5sG>EL~vw@֊ 4lo59+ 64A sj@^K\O\1`}*SeSu3kG5 Z<hWf/hv'f.@"$ -1%[χA5k̾< ً[a86ewXٛ8\<6Zc9g8| &Ȍxv'f-z&M-kJTѵR&We<\Fl=VU#a^'={=Ϲ.3Cb5"sE2.hp۟nE^οbeytdtA;eDbBܲbTnSMi7U,b@eM %w1@Wt:i;*뛺qr0xW@7.uv FaBz|^4ɐSYh:d:;{4hqĒV;Efl{@xg=%;ჹ؄Ks {叺˳c9F͝ 㸹\h@tO^2O h<4HVtf#sR;(.I9HA$oVpcb TWz/Ų J.kX&c+0ZZZN<6 \ t5\:먺Bn Q ݻՈ\FPn@pT?Gb36.s/Μܻ݄q Fgɮ{'j,iPS]D)^^Y8eh {zx ͇&qLHPܘܟR{!$h8X5%>7YcL^O/+}~~YBW?[q?ۡ$ZUBI$!^8g-erЎ+!wT8{^_G#wyA3ި/7BoTwΣP1N2mq19X^Y}.]w?}GԽ%bqw$Z+/IBI$! N)XaXҸy RI2t!*[*=UWWd@ޢP2;!a)3 S/#\eJmDҭH S.9e(^f&#F'2<ǥ!6>sqw&) <봎e?ϡ{qc qr@䚄2rMZIuPxc#KC+;iS k imXqa1Դ9FIK񿖢⠄%=vF<&'ލD޿Y,Td;[nVtk^Z%*mס3 Vs,wSN -ҼקBK Fj+Q}{llwU7TPhWzeHr@ 7p0e{qr:֋!ss 0I-+w_a#"q>..#>H"YX]fGi> 5ZǑZ8l^B Yh佣_Ua99db Ѕ?tѭIoV7{s=;tn3 i1Dq+UY#kIcta$ &腙4ֹ"(?M ֘a7\9DQ;<\p{WaKgd/ wv>,3Tץx{{>xjaz{  >"hue3jJW]\^x^S!wХ ͹7vb0bc!eBb;pᵏn 3v=bqry'5 0.n`0wAкDYMYF txВWYYC F-UiJ]Io~!nK`I+~(sHp;27V@ &A`X@=)OcR)i4 cI|yN9pY%X ^`H 핻[$Ί6 ssA͝Mnͺ123t 91h+]I,f;+\Ǐg!Fs?}wNua2n/`۷n&+ gUsKu9a÷ATiR+݊&j oGOeиZFFD۰q"!z #6I&VO3ѣ؞t7L+|6{=) hoajX(JHBSmhhh 9WI$B!I%>7AFOVX3 7^VoOn+}~~YB I$W^I$!BlpZ VCǟln0мLPƆ1f&\ُ=bn\FGMb JG9㰆Ǘ:bha!ĻUP5W\+ӊXah@>j7fnsP'Qjzv M||VFoG<+mPYka l*Mg q8nkLcp!B7Q8v vb35a,2g$kw^ p ~󷓬^>~'IےFǸaZɹ ]H,Fjp~ c,"xCj+3.D/{$T]k'VC.{vb6;ܢ@>@Q:Ia5|Ù4u&nV DW8Fps 2֙pL+OD6{d7C&Zh\Ʋ;.-VM1phݾ#kKA74s#8Ƥ z۹x8ፀLb([BBX~{u~>3yq_s9q9 n=Ǹ؎mC&څ3Aq ZuխA'*W8 Kh N47\K5<W0q;)$;R*U<\fU/nNfPV\ vnMF64r5>b]dKA2DyWz{2P#@5JM-Z.4qB!s8;bfO`z[z1 9K ]E)?0uD|uArRr+ہ d2uqOnV9\s8ۘ-e٧<0%2d[  jv-)@IHBLaaaE][I!B$I!B4J}ok欱g|1y?o|ޟf ^VoOnIjT! $HB"x᜴#-Y%杺<|6wq `3^$(cHQQO2I$|%OJ(I$BB ›\ъOrx:Ds/tM8pZ t/Q'!0TFV҃T!yoF,xZHк*ytAp]qF#nc q(s@Cמ[s+T/tab;\"u$GM[0U mU3Mf7<=y1*\iUfS  ¸/pveyv]^DIIp '. Z8%MJ;f70p$MzI R|]qge`n kA9ٌY&4 jHk9t}`VfJbh Ŗ4pm;)NpƗ7NHHViMn)0Hiۛ}Lq$Ta.UQDAκb(&ᙷ c\nRн %tXcA jBayXc et\wۜn}9o9S{1Cs$ DZ4\!e;R5)sZ69H֋S@hi9*2H)Bc;2"ۗ 876I pv!c C@QՃ]ZˍI(=q͙ zbF. q}K; k@=A"J)2,pŃz Z3kjlRtBhvt|RA=)4m[M]mxA=I$!BI$! $HB$k栣Aħ,;ੋ{oO6^z~'t KUuI$B!P WNSq;k7B^*i۫?t,=A)=Gܿ>>R,wvrrK;ЀΣ|Ҁ;IivX}sքtԹ8KN]ϱf_5/'ݮs3 0M2ɬ̷A$VVjd%7.v>b졭#RfEJg;}vI$\afI$+!W;}v3هl$I! Ufa $HBsهl#;}vp.7"AA$"R;x=anA'?;aAsBA$jPR!oټЌ~$U:PX:zXV6I$!BVU"RN:gTjCs! p kKqFa^ ۓӛ3IxzQ8yJKf[j'U,pE i㰝FLWsALgk{dSks B%ۀk0Rq)#3@5E:8" Ӂ xeQ[l]@" CsvnRrxh$:O kI.ؕ+;1K6 Paft1dՑ(J ZAiN@j\틚ޚ2/y5BQ~(s1F@4gDw 45G0A7>r&`qq194 )*e} V鲵4{Yԑa`0cann5 =2w4[\N*2j8*cxGf =k4;VUdDqFc\锍9$BKrj+aELstWn!5Y 4 $!XU]ZRVDfz0>`$I !$IBI$!BI$!Iy4@T #i|zVx6\NC.tU`3b:KIo#rܷZI-!$IB['C|%杺dvoUӷVKUXzR{;w}n}9m~}|XﯰE=wΤJbj ۹Dʦ&qX7Y ^ckLP.e&.K!,0Z <Vĸ#ht a璾?s7< ^!8 ^%)GBJPqVw>I$G!{w>s)$I#yxp^箝ϵz_oI$Gtpn^"s)w>I$tpn^"=t}7#N|RI$8AΎ Ä5Cƥ9J^^箝ϵz71".İHtF0 k[a $HPֆYI$B!$IBI$!BI$!I$B!${ /J=ywgnU; nFnO~z+nFnO~$Z+/EBI$%e5hM q IIm4B{1~b<,6 9 uPv4b 4zHvS'ß AdM{*9H2$FjGܿ>>R/;u?|7 snvl|7۬4`I^8<62g#@ΣFM!-:`x e )){3 ȉnaEn"i]7k7v[tYcp$ׂ8FB.E;|ZYnH hI*pN'=BG{Q +~{?ֽہpRd#l݇5 iS,;OjP#}J޷kn3 ݆KET߻/IE|&N░g2 $ iGvW~׏Z[w7!HgR ia9ׁU8#_gFG{Qݦ߻/o Ԍ]ˏ0^qҬp(Q p(Q Jx7SNG{?h߄Sh߄^ >!. >!UIЌ0//יݿV^gGv =Zp(Q pxUUfɃ5\AƗE DWWLm ~woըvaxg؎ Hx^]) rKq$t66| >S8t*GqT p;R>Z;H#ςTk~ }R=nxOz?gKBZ;#I;=a\o 9Ac7~6 0f'B-%6L짎n\nG,ˮi0 Au^˗֎FS4I_χzk^x7_'s߃Rwzt=WŨ\gfmWP$_8wG<_dg鯓D;v`BV^#/z񩲪=OmTdx؇ ‘\6 oՍkof ; ;j^;??vn!"BOxL܉pca#*޼샶Wɾo{FWri/I8Gξ2e֋ئmC- n6(I _oldol07@7sa 8 ס%6N&6> ٮ8\PK\#E UgtW^ƺ#3AO1k{a|k& ǀC ym/^JX[2c0;h6]T:P"w T"SDVg(tJVBI$!JI$!BI$!I$B(I$BIK<Ҁc]Yxۺq9Bۑ~[߭^ۑ~[߭BdRI4D"HѨJ^SzjUܵq_9Vns b;r0ڋ&7^ܛ۫:Do)"nsac>&\{}帟_}pz(|l^$Jk#pQIn&4f5wlZ45=T}wGZpw!v`b%NnmǹKw> 08sOw;>stream Adobed     '$''''$25552;;;;;;;;;;   ####''',,,   ####''',,,   ####''',,,z""   w!1AQ"aq4R23SrsBb #C$%&'()*56789:DEFGHIJTUVWXYZcdefghijtuvwxyz w!1AQ"2aqRs#3BSrb $%&'()*456789:CDEFGHIJTUVWXYZcdefghijtuvwxyz?]B@!A@!A@!A@!A@!A@!A@!A@!A@.-&* @H%A/;]7?*nrb햨Pók6+ 27`H9:;+I1 9.WGcu!R‚PX;tmחEЕ'T1r LTB.s!q+ %7Mh4:Q(uGnzXʩ`ShOIq#Q>nz-Bf&,heb*=L9F͛$:DxpX ɊR>xn_BhaҠ$%IUA!LՐ$kdLRHHx x㈼Bb`" " " " " " " sg4$:Y\^\'z )MU0~E'JDk15K$AE4i:9(%ʔJ#h B " ]B@!A@N϶8ߡUKJ: " r@BnH- N^OT'jK(U5C!N(jZR'3#͚ouTG/ex >4REûPEnx:HiԔW0RC֊hZml.v } +)3{ݬi|&+ |A΍${sQs^OZB\hB_,d'MC.lSe!Y|3!M|`zHmmC<>8 TL"Z򢸗YC PT,I&'x6GJ-, Ļ|!'%O<1djzj|Fm%$kaxnmlKΘ&:-Z*J,xB*dS*%'<\|R\ʉLF%{"JCZoąEebϡK«^} _oOd>hz}t^&>|/R|t! x>A)˻Qh D|5IL6g"J2Cx pRiʘ*fwrL/IQBTF3Ź{tI]e됙/$"˜_gxn D]M'gNJ#rOA.]~[A R=J$(1&L(JYԹJJ NօuO@iIcP h(\a&*eчaxt`9;G+3ӕ:#r[ȔKh~49dB_Ԯ\ٞDTĤ@d":Q=4LX&Kdʝ2ZSa %AZԏz>RT/O0Zg#Vdhv>Ւ'6zXanZE 'bTURH`uF"iOJ #AqFav!r0iwd@UR.-%Z("yQ#\y"_ROR1s49aE [/L\ɚMnF֤rꐵ6=cA|t@XB<_ŕ1 wM#2JaW4IK-ءpAQhlu+\p"ċLcǪiG;|<{y+V@ӭD=1<oLϗ#=y9*^9ZƤ[y^>Z5"ִԴRn]dP[|9"]+tC,%KBGm"9~WL~rsډEfE*].+#Z򥢄;nmg}ԽLXō(#c:DgI|<'\rтjH`NZ RAX71m~%h]%4/6٠w"ɫavscs1_~&(1(jB@@.T]C^8R RU=(Ar:-Vr؎/VjzV{6:( #rd O A-+_gNƗKnmꄰ-]ECow rh:j[Pb{ J”5nZOv-Y !vp"\NqfFՓNtr[o<@ gbli g&w cye=߉ x{CV8U6v,)2iB0pu"Jkڐ'b܍RRR R0ΩEv`4$R?곶odrε1y7Q<8&\$!.B+5c=9f! %m,O~l*!/A#^إԱZqw-of!d鄙,L;G-HGqLW O:HjDqJ_A+IZ 9$7 Qc.lk.;M6[ݘ\bB8-ؘ•MyָĦ">R%I&aC9jt#AaۄD&`JP(Q'H>HԢhHl=rFREt Y پUՊO#Q] _WH|Y#Уv_'͓]0Q )>|ORZrOO.+[ƑԢl{yW U.m%<$j9ǂ}HUnUJWSRjZf(Z9re> UXIg9 YTɇgOs|2"̵-$-;.is/eG' fR ŏ 5o) i{1'-hmԗ#ޯO:/RBɒ@gv9ŕ ;\vA)K& OevU,`tW+>PNjh6,C3Dë<+ c otBkjJMFU;Lr=(2pf>^bOC-ӥR.|52F8:=Tin^!{Y_-k pםkxQQ[iZq e 61BIT%+JT7 <ӕLB}R/bKz}?'Nu֒u_ 8mTl ʙֹmdxd/.ІJIi匌5quRzj:3ִH7pGkBBBIݱFPfD,*N}pCH+V $Bcb2G!qɀjk-jMmsETذg` Ս.L%%:ap/ycL\Ԭ!y&&H/:NJs\}TIߴ}iȀWfҹcc@&59Q *npx'Q(%!1t+Kq~؛!;Aq6Q\b~J]-)(eKUOf%rСrѪtZ)+G;!J % 1#H$JzC8ZJU#B{&\av349خ,OBOVbHGGN+MS޻=2犅HJ;OR @0Q 9Hxcif!.\Hs4}Q0O,;ep)s_\/eլ\]$Zi>ΔhL'ْz_#Uk^8&zUn6U*L ͜XB- ]BD$}P)ٕ#T iޜ}"3cjjObr#sԇF<=J-iHq-1"f)* hyYH:]r:|RT|BM@yk q6xR$ՠWb|ʔj<ӜGݢ"M D*P >O)C059AD8v7GQNXy OU*sQ*)8p>F׷jx9I^cL,"fQT>xN2&`@9gv%J^be:@3#H/q1K'.ꪪKݧܯ,^ytb$1ػq޳fq _­R!:=,D0 O|<3"n2e8ieM hBJJzrGxf:GkR\R7kkWc<7hF\ߨ+GeM%DI N)QG@Tւ571JiI`#&hV) >X1ﱔ߿9xUOfQ7W@]!~)>Ӹ>iIXt$74o*2I@S9ʪkWQ=2NM9("tKM\X(dF޻Uub}{jWwɌ;䟷l\}䟷l\WB#f=zW:Yy恞+f ЄD#`$%]iiK`=^ݡQJǩ-,ʢ_ !fJʗ2'=VI-g>;&9+O!b(cw"9u|d`I$e$_ JPLGNXq5Q_8zWqhWm.6\7F&6@tfCF$ˮsJn#!gfff##Й:RTLN &uTx,z]D5p9 \.x5mZ:z( nJƧtmN/gZEMGMO,4D܁r9shU %@؝#jgro*4UJ6t\)$ ᗊ F A%%ͯz=Õ!A$9>(*6Քp0r#kVgm%+ᡠꃃEX t=_DndhhGTr9E DSVS:R]@;c3Q1̰EJ8$׎<".I&*H3gtQqCԗ%C5:IaRn]gٔ.5 "񸑦'[+;[w*hqi`Yq;8{et4Odyl$!GʚTi C39OңU5JJg1F:tL{ Kw䃈Ӥ5;_',3 IdYivVi(,GRĴ`)s[xu*R! Uw\ P@ᗏ0-POKV`t/-FGUYe0 'LDu\N=&*RTc,})DA6 yHi콢uJe%LRNs-ҴIVwgEi.됺vM,#i%J ðXm%K!UYD<\LCuq7 NWC!q*A e@"l,B9z00LxO,gDD LMF9DhƿƊ"bMN=AqIq_V@j>_ 9'ZGH)chcZi[A#$ k4TpUAkƞ2_oLFY+I 1z}B@9+Bq*IBj6@]BD2_o }(@ӗ_G?5u}UDHG%.S] $G²3 O 5mKD㑙Pk|4coV1YC,3+WWbPOphQ I.C3ԤUHK aV>(Ñd;x1AeI, p%Wv|<0̛9kIWXga|nt"'xƔhţy)BepOxSE`_``iQrT9ѻK `elIH=@-q66I$sw?gMQRqE ݙDLAB[l>RdӪ R Gpǧ2d&H!|g(5 KTUk4mLݸrJ=rKipZ3;&cy =+J ̎v0as@F"XfLIQs-OI?G1k TenCiaĐ_9g"lAx̉KHIch6hlzVHG}J`t>&t{Cm,6)Ύz2YmJ1蜎^Ex$$%AZ%w,XNxJƦi~c`lAv@s߮H>PBKՎͣ) Z<$+IRc ޥze4U JK\[o'PǚvVDG6SԹF Uҳu: b#y: t[/$%ظq=H=i?oy>ظ!oGۂ"(4{hs&ETā͂"c$Z|B(BZIT[% +sԇFT)FvrQTE+{({y <8{ 6 4p =AlK{*-s(>_#3Kuk(A %H=3ES6PQ<K');yg5IJ*FW, 8%:[OPcOhRTN$do,QkxM#)GD9Ɲ-:mvrTԠ؈Y!7W1<TYDSPYgC~||tمhJTŘxb⍏[S NW92cxv!l-l͢ɣ8k7*2>I$q1O}I'%i)˩Ԝky#G9R <ܺ]@?Yb;.ZMȼʒf&\1Kkl G?''KDs%"TM]hmp 0W4\[ԑ~-_#DⲊ:sZ7(0yd-NKhɮr!I) KqAo-m[< rOh*͓'kDǠd' .sz[DG*Zwawc) pceO2T61T&; D=B'<_ivAMH,8)f50$ܧےDq]F{SԞb%RRuB=ɋRU3 -OͲ\`o~>o&`Qd؞`8[X\n%KK%77/(FY)<d+#l&ZJ'=I2j67O(tr)WY3wBNM S:XTiP1oROfLSԕ%āV_!nrskaJV׈&xPA]BDFz#`S;c#M)+ qkش~y#g-l}߀SF:`0,"h>/)J}< cBų[Ԧj4M*JvJb3F`)@ddef'; 舊JTLڢl%Ԥ? "FVFNʘ.. LB'|ɉWI$8$|6r%kT\vBMf+&69GbWFN"lYZK'(c0kbt@*? DԢZ_$-aʘY wͱ36sf?5RkBgLnȣdpJ>GKTN,"鞺ųl(1DtSi0 f,JY7Q1r֍-2PT Acę*0 bd zM|XX,k~2]#-i\`y/" m5ef$ vkPXw]Uy }mO$VRSa1@G=Sq-D,|r}-uN^˝pKM R)v=eKdB91"ˋV' RҐ XX?hGMR;R@I x#MFzjĢTIpl<4HJ(8B0)sp))6? Sӡvؐ:JX-ݕ{d: -*3{Vi IIle3e)\RA H,PfMW !q]dqY^ilDžDFz+jԢH 2z ʖ-|IrM̹&0p }RPNiWxIV:ۆAu}ڑH;2=sH(K@* x^Ș9wW)<|YU: S珰PNJ2--ݱniXd,5 @E7&؁М]+11#V#isQ$N곀۶$=*[45*I5|iL -ҢYYFKdCV9qzJF2 U @!Y0RZG4"KN@$>T=%) -ǀ6#IXۏ"cN HnACCϱಅ kcnQդiէ)J1JRlA[K?[U$$UpʨCک*T/fdve/j$? u[N1h> J& ]hQE_F1<.Nj |鞤\uTh#b~> LX q4!&dĆ I>vjgת)"JhK`NҐynH];rFMk {[c69Ɉ9a DLhPz?59D,x.aZ7%чUAhi.U{I2GPZk}ljA;ǴDQUpMnH>A>'tIm\☘SB BΚMG֤5?^sW qRMD(I>rc[ $ |oR5<]R;j&6"?$iߘ'0"$}t64%QO%O)fMBU1 LF%BC]BDyDu޹P<Yi&{uq3.V;qhy;eޝ1 ^:EsLpq6^#-_7ѨxȏlckG*HJ>$ҦRL~yqqsuzxPIA y̵02C>vI8(Q~G~$/: 2BGT%f9I*Z^'KBze:,;TBC'u$ rǸzO[6 o i4"T#c5+ `":9 (V@#Fseg18]ef ȾvTe=G2KR 9mWЀ;1,Gզj&RZݑb^.tbgԶ3ɹk@ooS(?+4\"#r(e+Pʛ-2fzW#JϬMyIR&K*J֠A耐F{cFVF(!a{$hu)Q{F-Y?mps#AI+)DĆ["fqD̰#'Rg5P$? VQCqhq]7n-lm i y4t\ q6S_Bm:F6sxS)=SI<.T$!J'pdKI2YOJJ[v1kxEw>qO b`gDߪsRJR_>h`['Oy#&,`k?"y;HRBLuP>/sz֏oL?#>f<өgT}x1oO:! X}x ,0^/N-DMd\ߩR*^mBb5) Zfz5Th~g̳1 h05]s@'BNau `t"Ò4&)J5J;:޼#BS:r-2ZlGui-hy6bT [\6dWom *6=".57:QiS(J$w˒(n|p]!i(T-3 J $D66MZ僔#Z5GBMͺTa oD̝=sm4ozdIB2TT|rSH %DݏMȒ %Sf)L.37e  *BF[k a^9;ܻê^$ECRɖK,tXBҠPQ#4sjw)t[ I;1Tfkǥ35k_$olr' nPRu SY^K2zNxϗ2VR*}ܹz.\$ɴoL($!UKpH;yOfc=G9^}>V!|QI{*hd.pAдR}^=A 'RĩGj*afWbLSy$RD“A&e ^/iԒhWrX*NZyl2rfWfYMQl#g4qAjK$Ls䏵ȼ&-J 4J2H&`)f$5=bfIM D@G$&} eBًI $1TJr*xRm9NMӪ@X8 >'d$,QGН–8gboSbJ9|_F[Rz#) fz+J\nSjK&x10b]BDؚ4*-Fz}Gdz+یRWPwϜTSnrOe! H9_o9ڈ<VG.㛞]ؗkG/BwIPϵT%Is zLjL D|u(ӡ$cfߒHJxܨ>:@`W*>Os҂AgNRtZY%) 䎪Pzʡ9\d!FK.ZHu0Iy#Hq6Q,W'FjDŽ|Rw< !}u$\GrI\=[ RJӫp 6]3ZrωxcKA6_!U< sZ/e9[&)L2lh B8][ir݀y[fI-EO0Z>TBOMU)TrὡP'Pi.V}rB)(@u-@ĨѾ@~  A~nyh{g`nWp_BU|95aS_1<ʃ[D`TR S8ԡ]F I4ZimhED~SSʃ@Q )Y w\,s4ߪ( lcLBrwUl*,R ޏ/YըI'1@ϟ0%AA"1,+O!")J_/16c9u2/P:ZuW <]R¦O+Lasߏ݉2Y(|(9rvIC}i@TsIV ٣pD'Q*Z 9A%kW@<Ĵ1)d O|&@%)c*;" w ঁTOqQOT bΜjsؑh7LIr4%'WD8+.y=8.q~KW+ՊC >,i'ĩ0֦ZY΁HV[S)J9?HOsJfH1yCԋ*RGi!洚yl܉inTLuM[묧>K1ޯ GO#}Y^>G*|ySΨB/^ َJxH%@4u ~cfYТ&8ٳ,LUҭecĘ~l5ՠZȐ#4|<}D)wYKM3 D &^ v4m@$8 (P}ݮݑy E#<1yH6߉X=h3^n| gEyR廛 R>7ZҔҐ.=9&PDo- heiصšݖӤw.I"ζ5;γ !iB,z+'#D&ZUπxO>L;\_s| L(J[ͻ_nCxuSmx_Q]r|B.ZQApb“`CkT=2y#mBly14g\PBJA)R]%ty&.yA>r5롁#o9liu*QJk&.dJ 7>$&UYNm*9g5'"Iڪb181(r@Lڀoޏ4=|ۼr*T 쏻̧]) /&O"C[mKH\rՒRDI W;F&|F7:ED}DZu3PjSש"ޱOnW"m0f?$=RnKvt! >A]BU *z&BgYib?$ZO~a+Y9@L=SD=F~a5?o=oʏi*vָ`:ȣr.$x}ICvRx35 &PV:ى}/R}IW)MJ RދrIWv!3nWPt孮ɧ1֔GFanVӝBDX-8JOTyڔ[v'<Lfۆjq A#W8Oe EM<TI)$I)2޹aϊZʈ`n)$pkG$DI\ނ%jg12o7RcwFӖ!R7cr_'IY"Y/[9Nc,oY+wR H-y%::ZM%6 8 3<|)-Yf>JYnFDQj-a!d.a]XAHܯ2eB6 r4[%S(1$,>%LW(@ Ҏ "vːԨt%XAO Lcs$sFY5W ݡUyirR:-NgA!CQ$aNO7S=gP )fpG`O7_ր1 sr a{dR8ul4!dU|Rxԡ {]F ]ߎ"$r%#OA:^:LuK[묧>K1ޯ#>f<өgT}x1oO:$! X}x /8. f|rU]kFwӡ145>]2% g7CY7Ч&C9FYR{Ĉ}(t9 'D* KB YmɕZM@O1Y} icϺ2E=yR\|,&$FfBsSkIE2HS2;GFKII)l\<:.LT23ٴ|N]I.r҉`$d6;Rr\8r\ɈH$!ǣ{4-?JRJ0@geTd%4#7L.L%jZUB"4|甴i n"rg;=*hA)xi!Wqs!{u~4#t$Ȑ@Ni4 HRd BP_kIqzk.WD2"bԞzv[웑ᆙڑ- nRG$h]K^FZp&%3g#Ig1R٢$Mto'@*0lA^D"bBG !I%*/ڠoߏ5 \-Z\d*fm>Lr>RfMD4>cD\$dܛGSk$-.F{Lc rRyhUH1@!LDuAXi@擴 $={M^>'5{M=Mw:y& yc0t5>ޑ(eL乀?=4{/.9~&Co3+Џ.Q$r@JdLuw1]Bj6@]B ?(Sr5P+}`xIYKB|>7/y^S8&MQqD~d>r4́Jnl[()\5s1Eiey۟XzesA~W>+J5Z!JɄpEXaYru3ΐVII+pQoIZQ:3hu 9"ܚLVI%>%u9/RL|QiB3TPܿMr炫ʜ$F⭗J"c 4laЌ(+ᠱRA, &]zX~UDu7|~L쨨7{lcL붓>J6Z:3Ggw0 㲕}7uCqbH~$}I5en䴕LV'R8ݧ}RX^Zy7E}f8Rcsrܩ.NA/E!@@)WZ($;qi]NN\DJ| Wf1CW9..9\ͥVc;'(nMNBBvBJ0,㏙1kȪ,£,t|,ɓ*R8ǔF)g EauOV m;t 5H2a2ǔSթRhDU8{~ZrPzUM)4=Srq T'SND,C]sZә >$,ؠ{|!w_سr{V teC4ĝdjQ*ndgo'~&Kw[@ӡACUlI%VB:9xcڳXu&.l&J`R9=8`mkm E*qJ;ƈ!%Y%R@)'>#? )b$>Ɛ}NO'R)<NĤBz*!J qT,sf 67/4пh\FE&Iv|gkiJF U\l}>ryY]j'P In~I4鮀W~yʺYiRYۤ= )Q 떗V%-ʳ9SM5L̫T$@z'hӪ륋:=֢.e}prf92+T{lWª#r:Z*_('ɿ:Z9.WQN_]SHFįW#}bOKt{p>F՜tjp u{Dxcȟ>}^J-bv\Kܢ:_~ӋPD)+9KtM->!Og%dž>^2>ScuHn R`:iz{vd"j!mTRmύ͜-+I :;F\zҹ9Lk7܎rܩ)#9u\rI\DT%_X}J%+Y\ajS$5(!N;%.d \9_W h9>M/&4i/rc-olBh\V>ڀG=eN;Z2E@I==%&^# RU(k/fD@b%+Q''|ǗZIJ%` mk?;U\Z=*AL/*4~^N'LdX374[TeߴCO)w*<ϯ]Bj6@]^|}R$`˔Q$ $^O g$~Wjm@PU4J\+$4cK]PbeCV)'1=;Olr}G_U^|Ѻ_dK),t8<+KiGEN8XzBrP2cn'/&5&dziԨ%F4LjK) ">^U6m|LoJeu, :셱I\#؁uףHvk@(j_$O7?2uAZCE Q3O.Y T{ y_{S*_sLKڊOTTƙi8}}s,8:'oE^y ,H#'uЂաe!8lL A$,_; iZÃV!moMIp>ۜ}<4t6is&3'6kljfg:+'M(KI%GQ& 5N;y@|kJT(7;`3 #R;V3җ)N89gPfԗ) ]xaEAL&󽄠hn/m 鯑fdy7Nv q,c;Z5VZw AZu*hbmRTPCPWJ]mn^g2WuIu{᣷"N(mg.TGMȉNniF`<2gj>h,pN/ NDO7+Ybae薕SQ'Ã&Qy&u{<Ȏե/ikCsBzԽS36DN銖 K<1rSQKcb|Khm >6baov;^'[]Q׼ܸ Ȃ7K }" 76Y5E@\GV<|]$7%uX=q;bR3cZC%; 4)K[G IK;;ܡ$;Nh=\ҕM)H c̹<*W(ʙfbX#MГxGreaFqe̩>'(LQpf[K"/9:z&_#Jd!$`%`wU;h39c2WgP)Gy9 cJ7*%+{XuSE&>ΏnGȟ>}^J"E{*"Bׂ"܃Mr'!>uv`|nnZC}+HmB?L| Gӥ=fŢqAXNdN|K #qc])V,/6 _}a}{0p֘FNq|.$L#.$t2 .UУZ ٩`gBb)ŋ mD!TI7{9Oɩ;-1d,Ҷ577U+G"pB)@Sa~$:\ۀwB/G}ᥨ_Byt$Meo,xr@"gN:7_D's*zǙ4^0%%駱 "cT[sfE6k^g6Fn豷' qKCeW9:ȋ9?V;b;rj ~Uä6te=!(a#zrgzi檭f`$/s+>hBTf5Mܥ?A*\Ί왼ҺH c;NJNig%K̥tf3]v=sUZMNUsa@YЧRTNA0>w(ʖFzI(X-꺔_9vrcrIn*hBfxDYR>)Iz$v )"lJꥱ'לW6%tf"LէLO ? J@d5%*.w@Q wB,M3qZƁ^7 Fd (j| \-F\u>3JBdz䊒|>W,-J%IU?>ȥc @㊈BwPAXaiԵ9zBo.?brw zTPI>>|8NV) SrA$vtVbR^ӕ2/PT$v;џ"re|e}gi! >A]] z먞i0Y <||@cVw*K%9Րj#0eWd`:|k7y⽌FrIZPD2R8$9G'plz^T4! ?m?JVTiƅCeZG|0uM$QM}ɸܭ6?luau5HSm2֬"Nc9%i"ts Hw)1 U΀_ДsB? ui*b%<BTz1H5WNA=+;_gS\F̎~љΔrnu0CrLPEi[!uHttܝ2rJB35BjW-h(Hsxe.ͤ&ɴF*Z3v5Z:ȮJ|7mRr!kEL@e-+ND)j衰Bu/`0Ni\MDg:~NI%+t”z=oHTlZ90V;:EkV yo@AHk1t&}6K6  bM|Vʔ68HZobS@ G)˼=:BAS>}UZTIٚØuʁ%$ p8s5ƒ21HpV$P>2"`kݑϑ{"{n*3Aq>\eJZI'{*e Oy+B-A7g`VO[6'vi.j$Vd8 QI 1SqvjbO_sr~2jZS lWҕMHIiAAvzY.Z. C:UwQfR>1AH罬hun:c1> pݟJ̤R^ tbdo8gW%DH>{A θ3AѾ'Pe&QyhQ.xS+A)J!=T9c%,aΈZ(͚ӥmx^m-iasq6Vel"'-sf) Hq y;9*\yBJnG҅&Qޡ'_PҮ`$&YIcJb{" & (6ܻ.y=KወSk#BdȱHS?GKԥZY5 C#*N(,%{;U&G[5ԕ6c5 "cNPPTpia4sPrH)&:UX 5+;ʮHOh4q5UDD|UN{C% "^k"6JRK`M'ԛPSn4D V+Q)[ܯFze;L)7 t{p>DݪT}xg/vQ^>Aʒu@rVf֍'%YxZWʜvyc銩A;;G#%_F ק얭ղ˴lST3@|n#q H.V5>@Q+׀$ A1 ])+6Z։Ea1DF:*RdlN=ۿ]!2f=8揘Jݧ>()N')ew^奲s[N-<.ۛ>d娪(&!c"tRjQm$l3\DDŽp(^j^ZgtR ; wűрwor(H]Rf%#n7R+Tk4l%)6l{ f rI(CO}"p^;xjpv M@^9ORRyzE6ITj1ǞRJ i%[(ΨfUDG4j6; xJ 'aNPIkFj٩ wuٚjL-| <ASSjD;0״ЬRH[ lowO\2Z&R$) RpA G%I n+gH4\tI2L:h-PG/ʚt VTJI]VfRhB ,R0~,zbП/ۡ~Vd-D9Wi.k"r j51?{'M9ER5YϵDT=+>C>["_nַ\}79:MzjM! Z#)|.\VKZc9coP2w$kG5 8h2%a` ni>%2;A-\w5Vf6` m:.j'B4Xj%3R1PM^Nh@9XNJ9v.r t㢢Q%cÒǿ Ul<"pI|JBӭE O1U-4 z@RJ8521@X&aTu$/7U꼨sG'>r.S%j9D"Q/QGrIʴx!GsEN큷ex쨘~ {[eE֍+.i'S1^x_RWIyrrDT_NISԒGdo$sRBj&MTIпǬ5oΛqcv B]Sd>]@ʡj.GX]GfRӽe31%m#Ԙ5ceh>2l(xR"77y⺄LƝ =577;QJZ$0pCG ^ؘ˕TQŧ)N#%JB@y!nSMZ Z}pP+Z؃O03 \u=V#żY/Y+_RۍIDߌ} Dx{i=ڹTէd=cc:O~uq^ru8+}28)!kt@/bsL2'hlnZzev ]fЧ"sZס"3jD̔W_ 葭(LzPm?%!&QWV 9ɢn$&R+e0ə#y'.rP5-xT @a4StJt$dRO/JN[DS=U8 s3J O(K% h:ĉa0j;=%I>8M s[0aolk{ w$ Ce3P`9nRӪTقZ\K8J!Nݣ1reBaUG `o762ƴZchlqg}jΊ KjH,RʦS>7($#I4˘op"3B*ҥ-$C1{PX9 mo=s*"oe^!o9 (JT{T$ЃCϚ:`MOU)!q)knD 2PE.΢ `Eecv$H?[m\duj|)Z]!*IlAK>aIv=e:]Tӥ*1!\#-^f.aCKKw_/ZMG9ILM3p<'AijB"d 3 8"PsvnN#h.Fr.a|* ,R >N"DDfIp-ѻ 1";O|R&:I>lf(&9Z㦗.Le!gl-厨$eo9 q6=K!]&lK|}ҙ$2!/cj8ٸ*y!a@9]NU/C! )jQ'7>RY L8 R_MkQq?lj<)7 f'_ ?}wj^>1YDH䢤e? D(Bx0A\R1V*P=HNoE/.nl^>KI! %<˩{>֩zǍ9ۙ\neAj ,$G&Y)4W14`>~IV ,!NJ['Vuc+&<<ٷ[h%es )'eQH)]5ԂtNNluRHfWykr~Ljyb1J%eٴI*w)OѻbLj ip7e-k!l2u-6B삚g*f=1F ]d: l4|NKLn,jj;%x5ZM {Rzy(q2Ā@9G{%o-I0<ÈB"x IsIVr7b$.#r|@5ţr$K%+k,LZ&/I#;3ԕr ]Ph1G9tj]-emj {Ox,ÙZ[+k j5 oj9N3w i"`URSMčFFxq> 3VVb\T@ HetrД$`ED^CV|(iʞ, 'wF˞i5PS;Nbՠ17.)c}Klp؛$48 bS)2$TOi3g$Р*yQK1 KHv߲>o&5snq`u%F TAKpUE$(J&AԙMtq3%`̀ P@a- oZ\!vaz==֦"8^k\5S$uTD)$s ncBJ櫭0') ,d!DD@bo1 `y(-یDOgB} rRY^rcu4|hQ. z=l24|,cmWE RRjI4;~2m7OdO&|9kBq} ]R{zҢRdp[Uz` !i޳_j>G7̧S=^>OOI+NzvJ*HtwsIN/3z0+y;V*m<=!OHf |^Mfmժ:d)$*pthh9o>iA'$b E\yKH?8ܤ a5'-䣧$v :tYlԴ*c,qk쉆i[6a A: n73`sN4Mrښv7g,-fM1p}4f>^b&]` Hy?Sͪ\%*YHSzX5K6RX}1s\ooMg9m67 68٬wq+1:=/) Sa 'XZp5IW*-F|T7dGGGS3}zr~3래<f}%qRtKQin"&=%6-[UWV^KѬ61lXE6F-[(anQ5r/ּuzALKrz#`@ii! mD*QQw'4 pvdԴ\x}J%JKMqA,AFַۀy+i4.rɄ8T73gA*42B@su1jYuvt>Fi ySl vh kˣPj* +/+jT#I˦\H+Y@l9L%jڪ&5,qlOGYַZk[Uцe{hp8a\D%sߦ<8JA'ZO)D#mTҪ)1#h 5WڎŐV L$Ś#nG"LB塍+ `vQ0@[e1>EY+QHxs'6װuNv[\KEm|+&؜S:Ixcp@s|VylA@1rq#NZH9K k$ycժT̗6T7jx2JR )$ RPS()9X\F1)Eje.tqozv#j\@9 (\#$N2hyV|!NBGG˚ꚠ C&-ĈnZTL5(9qMAQ[@ 0qx^DZݰ.]t _dUH*G)evs 5oNY?5-x͖&ʞReIdZqx )dFzq+RˊH)< L6vɅT"X*Z@,TXxaFilQ \X4qϬ-h̷;BLe Q}-*KRO/8ej`ꨭߠ:"2F2!2d(.i'MP2#u_"@K,Z,zJ11+%;1kW2^Dd`@wѩPkZ:V'2"ۄfW*'hxPA,xjfrj s% ~MiZQLR,ZZZ@znI҃@ eGt9uծ#䙧Й~baE(jghQ2[6_%iXxAֻMERCی}.H_dBF* FCzW*pycRcdb䏙vO&>̽m!L ]Sy\(qа7H>¦^/ N{R=Gcy~&Gڏ>Pii0z"J>)iRCR/j>/+ Moj>G/TK,li.uWic𞰈#u%M;eH* Ui#Z/ӄ6IsUՉ d e3ij Q2GK?i K Z#1ˬ]@nt:%toɌyEuߢ[2ܬQQ>Y`I<LJR:SsqN[hwVt@ /R4s*C!.RYdOJIdP~*WU5#8sm3 xh>9M**j ӄTWL}B#խ"Y= >ij%kJ3ʰT}/.t#V eQ87 wJzMe#et]s,q:yk.풑ًzuD& &b!=v0L]SjHt霛 0R$ XfU1unjdTw7]bcй"i$먜wt\tSB6.[Ќ/=2O҆kugW:Y$.1vp9X* 50""#PWto17 9A8T>)@}(2?o^1>"~jYn~>|DԳ>T@5[F꫼bUU1nsTMqvIZK8+Ց0?$Ys8HHQ票j{-xkҤ2AvBdSIMn$9NS撤V\䄹`7c]U{vqG [ uS %ec ;/s:ey99_Tԟ4҄PJRl;/#zMDL|. >v&dp4Ga"ٵgx ]x'0UAĬ\Xs 7q=J$˜&bRAr89ր96/H'! v>x[+R'2aܩ-]SI=e -EbDIy෩6ٔ ϔFF:\ɲhlюZı\\. I3ZtU-eVO s}xvň D%9s2TɰXߎ4mRyɊҠn3i "YuP<}yQu+Dy&bC1IܐtWVx-Z[%S:vYEmp?e9CY>ziTR[}LsdϒV:Z8Qw<%sl玊N&Rwe#\n5]GB2$)`یdW646B t|.͑S:OSJ2F-"b/[KNh3ֲTMyF$S2fy`Kc(GJF3^ #"HQ?4m*P9tx#jJ2Z8(hW(M:V%g.=,"zB̵ UF!>\UzH5!gT T9 X s u4FgWWH:Pd28|lޭ <|h#9zH}#;Vdjʗͅ9 ͈K+K9:%OE). kF9*H3TVsRa%)s졏1׶h<[*bcАR,vLMgՔz ,&i.dfфJJvt%ܬ>*B e9Tz@2JD9)P-KT_O#*+&Ĭ[.;-'tqTZYy\M֒Xwj%kϜG3;⥭l'ɟ=+;Å4)2WEK%A RJ44d ! pcz˗ݬqi/7|Qp=4u'1DLB!1ق ]SEܳu*4}7Ig'ӥ{ZoT{:=G_;JjcG_-LY=!c+\)!ԭyπ1#D~% EW"c)bFS8-dJk!&[hf2ޥ`2q: b&$!LtnϜn"bId&6zZcTԔߤT/NKr8ۋIhշpcG*XQv, l ] chR27p4GGPJ4t#.|<úT *RNA'Nӛ_aĝBRTKx2tV#ͫdSc8 jeSyk gzY铧[REHTR@!V !A3TLV0 L#{)ŚۆW`M;&\bOR]79z\ k 25RJ3A(A#"@\0Qpaw$%jRCqJ(D7˖7C0k!nBkMXuF$AȎ0F̤s|T8cz9#cGEfm$c@*H缞` y;='֑ߺ,&ug>&՜*U̝&<֡}+zFW j VxqI(g8U-cLi5̌;{9mM75G ]VXAӚR +)r+ Ԗ#~B$JU4:F݁sN%: 'w&^pObͣj(GdǛ fC\VU#*4n.sѢSZYjyqX[Ĩtyq:ڨ9 uJe/ҡr.`E5-A3WVpP~a &Նc=4|gjq(mҖ]g bU.)b{ı 9*Ze Pp vI'G>ճ={W B@ 0R_6ԨAMehTPm*%c%aЂm~kkgk,yqT&\j1!HXb±A"hÐ.b4N'GtIi :I T ]-RNJbxoQiJ .= !=dss&VNG' ژpОעE- z9!2Du,-wH)ifi .zL^ĐH[F yO=wA-S!XlQj2צiSeMI.^| ŹWt&D Jqߎb|}{:euOm<:8>f^2 ENcjƱT%)H5x8|^+3I_>~S':SQko']TՓPSQ8>4]Sw;s+"v؂zT-7=B AA+6,_)-R33YTEh!%DT#j[BClI%TL˧;!Љ#k_ |P(%R ^>ް{$H-@%өJZiN 5k҉Z͊RHٮol= =DQ4hr8(4[GEPjc6NA -I.>_&kQ6nQ2l%!(Z PRl*X@;՛_07(7L꒛twTT!&=1@JO}A߸'r5J=VRwLgzMGl?eKW&~ȯ4u1I>"\RJq$>|RD?-gtą%QD#Œ=^+{S-^tfޫ>_̟K_QLLI8Gзҳߘ>6-`]S@oq:_b<ĝQiݳL}j-7۶wTjXDHq|% ?f>\cyj#y@ :mY1&))%V*8"p}|{!=DT l{ُYvqWƍMx Jpk}4DFzs1Hk{絊w[1Zf]-@R"4sO,&͑:5rV˛v".cC":N &,8y }I+H6/Fcܿ[C&=J="\zvc) YM:5JGL6(T(l>'+~B$ *,ucx$ըͽ0{ۅ*31櫕cpwYN@"iĀCn؏'z%r"JPT/؞cBZ/-,1B8|Ŕ%M[?Ȓ̞wAP!+A-Dbٻa9thP%$9՘G&)Wt7oUWj4K ]|;*E|Lk/ 4<ޫE*]EHaJ'c˖N#d1J'ʒ0TFC:s)֠E#1e,vVs$Sa%gѸ3  ZI4_X֌MWMDZfGs eԨiA #eϒJP৉x20􁨿#Q9JZ$vrhwlHT38nY\^&kH<-VC#02uVg:/, #֞^}+ *J|B4ꉠHgB@v*08Uxو9`F Ȑ:Ԧ<%S9z@*XW/Tu[6ͪT(Rp+Q8 RB.co-+jk/EzOays{vthԯ:(,esoM/:t*IJ‚f)$vsU- .\۴43V5\03 40呇>n_2O*s9?\r9QyA@J/n}cIPq Ť8# 3 3+ IDRo5>|U35Bu\}Ks W/a6Q|:S\K4R\w͓3U2Y)IRZVRa[$7OI>r&&WDk!{ H|j[HǫB,8LrhdqE"|,$S|9OQ-JPX'Bfsҽx!/x|!25)D Ma\B99KMKn]XЈ~dɲ/,ҐnwNld[ (RDʦZOG4oYws:l &+fі?AQ1JwI9%I-nx :IR4r4_X3ԓG)h:TMN $!NSTK%&Nrۭb*M.Җwv<ri|.3RZyk_rbsZ.NKr6dꍍW؜TT2IL!/)v` @u+#P*%6 HӹNN2tk q\T\)٪ EB\dȭh,"JJyKKʜ$itHҭ2ҕH!fbj&hJK<2\CԽn eLBs8TwxX x$/vezgE\}޼yDʒ 1<ё(૨0FNw˘R]cE•AP"h?R9B]xc&l@ؖz> j.º2B,x/qqԕͳ W+舏/L(`KIL22 ꖢ }^ћV2-h6wZyv9'/I'4zNb%5'} INYj}c3$x5)܏CYDV>/'4_o]'?,oꧺ$אo]S/wQ7vK>RcjazLm0̟{l1ʓAsZil; 9OsnKFH|;-bA]SSʤ M̿Lc|Yw!ec.Qe|3ݲT@\ &ĕ^>sJRgJ ҕ%@GG'OTIIfZbf%#,n޻R񶥹yQ2% _",@M[ZCŦUk%m!kr6P` 8$9RSz᷒>ƨtג{ؼ|hJiJKct8\,aV$l}-N}Anw*{EyioF)@޶t K2{`!/i1Ziw躣%O4C#LWu\G Ψ㘰UT#وx;+FAPEK4tJ4%,%%#sTu) QSQς>v̪|̔ cK.5mG/EٹU77pA!kq` =SLjX`}T^*_瑱AWFz}luP`}Z>ޚrD5܆V xZ>h$12.DܰizNsmgiB1Rَ ѶHy.mx$k|7$˦OKc}^ *yCZπ$n[Qq)h<5U䳁poFRX?o5Љ%2e^i, S<ӥ&Y$RzlCl_ V4r%gB5#֬3mM1mw Whc_LA"ǫ-#Ĕy`*p-cB9IK J cW4j53?&i&,!EbAK#=O$̖J\piC o1YaQjYX9`/` ֽVf>vrN]fKJ[&,6im@rOyaʒ;'PB%4 YOB:T&uUͬ=$>grL YPdsu1 &\D<,/sZk/D`Ç.9ok]s=]#+eEㅎ+y= "_ut@?>$Љ29 ] Σ|XF&N.7C˞qx ˎFz)U$䊐a0 I160؇ݤg񒻎K \rnDC|/u8nŠ;%*P* G(J\TɓN%WS)jQjCPUZ 5K]W!8SDA![{`=}2Y+f+p⹒C.v{!(ډ2!'Iʻ3&:xsKY!C_BZň?\bP6@Ov,MZ}tv1YT& v포t֠: WR4搫C$ЄSJCUQ6S7 ak| JdZ8z [Lbȵ^p6 kH>tx`}y]ozbx |4|~L"\uS-K)*Jv>$jt*a Tj@-ŘFR 2rM+biexH0J5Hj]ymUp،ۀ2(<)kq81."Ń ^UTFhlpyawk_sZQ%Cj$-{*IGlQ*&m2)耥(|~͚%ɗ%O_6EAl2r,MNNMW)͘\) Rnbk.qE/uG}/S?V׋qek|♮v Wz Jzi(S{,FB}%`叭7Q*l2GK&&M>Hחr6É R[x:e봺:d k@%5 8y^\Mϟ.TrGDh~lXo%N-ۂ8fxvw:B seq{\,dAt)LK* f!]U$x^j#$nIVZ: )BZ%)OI 9{(2ԫ5 E4K>׏Ddʑ2ZLI@JR1[ux\,a q9"$U9*iyM&RY[whHO:jRl1WEr;7SB J}Z6l#^ 4x/uuTf&F̙WtrlݱIR_P:40$q tI+.aU*W¥ 2§ˍɬiut+HZ(oq"oE,UWK~0ZW&znR6:eJP+Q':r.m/gbuGp\B6VQ _jdqOezVTF9pи*GIQ#֧|)9aOi}H:K1#$CYj-a.DpRP1!Zh ]S<ږ1>% F^CݛYIQ l+8͐՘q>>g2d|>s3S\l24ԡDJHy*PUOOM 72^ꑗ(Өi=%`)$O$*aĎ~:nIBG1,L폥V_QjIs"ݑG$sr&&kyK>/hZs?n}{)v?},9Q8I,GzYYH;?Jg(ii!PI"Yㄻ^>f2[I5S)oYXuk䱠]%,N 8'i4Ip۸VnZNaTTlnH? NwMIQN΂G%fbG2N&^BH><<zjr,Qx9$07 {v87S+,˖;-,bʹ%{yO`8tYVI;!i lkFR4:ig jPDR_"c($MR˘|n t.D5 #U%t(Pf-&L1XlO%ec1A#d \<RieD+g)1$xjȓ._Q O)BJGxm4H 4V sG $iK7BJK y#RЎkR-pߍhR:r΅mSјu .ĎƤt.tq G$J%}ňBSy>OMH@RMˈFO* dsiOICgPfK jA,y|]ep#<@n+^ĎsF"EZ ҀZe 6'&_'ZURLsZ:k 9 7,8 ?LM6eid+vsю~ ;+\bi;LDtRY"$* w!'-eͼH Rmo`DYI,g"r+^d|mlnX*1;: ַȸA jZXHGLRmaęS(BDk!l:lZYE; a԰ { IDZ/g)*Bj#GğVzd͉Mdž?]&LLR[wѲَs *~ #T8\gn8S*H* J!Z B)7ٕx̡HIRA[6ΧƩɔsՠ&\gbr4[Wv[!fiae2menG6@BvGL)=5, ݷerǪ(ٻx]Z *I(J!$,es%IsGZºkZGY5&g^v-k* ~TZiR_: =1Hݠ1M&%HGxZM)@y+K.T0{ݷ7PJi4e֠' bc4^=~BeM@Loh\՚ J,|$,t(RXW`b=8oRpmO|r*]FSy:DΤرeUњ%! 1$W|Ե$ #4I@ -mY^VE7W-)lGcip VG+&"2lːfL(v5沄,Lsic>^'jLd-F΍IJFCAxpmt+]`@h + (qMeZACZ]`\ЪBʒPuy8q/h"bkUB !,c}7&ΖHLUSs偯kX㣎#y 6ļZ܁?sDLZvZ͜,$KnDNVN]`}Uf9QTf)8FĄ{aW'b@JKU#^[.n '$C2oqm1qj@j y\>l(j&‡&94%&MNNM,! C* *%l}EusA%.Q% nBCTx=&ɔeZ>aBah=n.([%K@ nHفG\$"Īa@动%VPvhu5HM$vK:k*o8+奋XTxCPgʖdS$@3w|,TY $y{"T1 mac×-ͅsTyIꦋ┏m" I@IO GHQ]t؜CNA 8zRyjWV үO揙MjJHdc4žS@+J.P <kW\7'R+Y'reQϢF2S4K,H5e(HnF XNj'- i$8N/Nh JSZүoc2S4IX{1b#+>aZe >dDIզ*"&ruqΫW5D'*PKv;1Й\V]_yHdI /P 4/plsYt&rRAc[RfPP|N8iҀ4Ґ螢A4vM*cϴ=TfIZ\ Ԓpgh'W\'SևR4sY+QQu{MOK'/d.l( >"*Z+|iYN.dBҢfK &NيL]h!L|>\OOɪ-9Sj&i,}yJB^TmNOHV|LkS1!AI!P\^yW+=%h[L~2.=hdGp'̣Wc]]c1=I~e'V-bA]SGΥzsB2F=7~¦z@| N꿡ROO;TeQJ;%JQQ~Hj- RL)j#HȅB/b 4RQQ!Fsd˜f$(|,jir aAF㽱Y 5UËs A(98"&8S*Z8Fj5 uҵ bA&w#LA UĢஉ鲍E$3RP adK2ҰKl,SυeJ]^8HdIB| K`D(3I#P@JWXF jJ eR掂j*H)!RRcG)ddsMGUqlo8"<~Iy I#!Kj%LeE,qVx 1#))SIFvpZ4޼p GKP<  J-$I F魔;FuZ}b%JeDh#(R 'HJY$6.l|h%JS6D씪f[W@i PHcx@L9g,,9~ʃKJD"j5R0hZ蓷FGIh!yuFFJ*KD_͉D$sPctq"l( ~#4Txc)Ai$Ax똒Jgʅ`GnzjpE bvLAPR,q)֕oKÐ排iZA[86z aNVƫ#YaLT&sMD*blqMg՚#R) * rnM1:]NLRДNjU`Z(U=S'{%fH4ܷm8*.u($,I>0Gw)\`V@~";M9a`9/ߏ.ju "yA'dGڕ3HW(M)Y^+R܆g1Ikl8N)Ag5,B0du%C_xze2R -7H`,<#h|Ƿ3 bhdun f2_׻)xGb7jܑ|ɜ$dsR  F( )bH1PP \GA{mدԹ/!I,48JAQ>/V@ N zX<>Avo{ Au ӽwrLuԝG(#Besn$TH7sz3N8c[zd%XpS82W1d;ґfL49K]#պf`S !3*XNZ$t-.az*.Ic-{ U6)>hjW,yIZQ-SY[6c<ژ.r@ܷhLTB!&|(0lpfs^wfaHI@s!L S]ry.ȂDi(-"OJJ]j9;>)2VmulZ1_$U4N\(JFP-ON`t]z*`0W{ui*3#N 盔AhssnJB$ا p;r"ڔMW/R':QQ鴚):)b\1$JDy7$#U49G{ 3b :VRқNѹoYc)EP#<ɪJ,yP+]iAAA$hk"`e(v;̢e3,rR59А#r&B9ރ{{˝T*Xv@ z c;M"xifH'ǘp#z!Ыٮ:=4D+SvPP P q)Z:` +c97/}_ %UT_;0ėnwU6:B M4=u@=~agE*|>l9;Y)f)!6$@ TVl$m~kJCs`ɠyaMC ,K[~;swၗ> ˉY͎NRΖA]&aE]j*X*T6rcU5ET!}>{-=.SrlA$j@R#\o @ c| {{S:fGHj'(RP<3+QʉƓ%хx1 'wIL6[,94 mҩ w>fHGJin >ƞQ**%ʘ(Y~䬲v~υ؎@Q:7,YL>&siP+BNǿ.LvHH ߼|WJfmpDtY3-촮HDLt8*z)DǶDc,A ̀.AE @"mV WYﹿ9]`;@T|AMRF~# dA)fCeP<>ZAU-}~Ub'r,cFw. yq`;%-l`lHp]^@|y;&k32SH7DyIh9XEjl3h/DGFtBwnb @۪^^tؐ;+{Q5զZxu<&ɻNFnt꫺w2QNS%iڛfFyst$5D(OG^4rMSg{ňh`% J@ 3M'=ԮP#raJ2gH,l>染f2*q B"`" 8^ib pGP(dAp`l}=*|i@IkO2HS! =OL^ >u=QzSE-c\JH xC_I¤]ƏԺM;$KBR6 nBQLA]BE)%^L/áVSCW47i?IeɘsJKiUCbnXZҪXIK7΋U+UȖȖ1I\RT}e%H"lF\ʺzA:}AWMh7:H tQC4T&|#Q sR\7&&!Bx2;ia+󳽀}s~>O|ox)QnPܿp{Nr)ia#x29>G >>}ECr;- Bx2;ia#{+_Ͼc w[?Kg嘆(~, Bx2;ia#{+_Ͼc w[?Kg;-%3^' oEwg{ 3PGŒ;-%3hTݴ0MN`}Z}sf2^LǪZK~Sܡ_8=}ECdq**wlD-7i9jo0E/X_)a .Q"$D{=uR9cV#.xc$-?F!ە_Q,չ7zu~q^_ zI \m C㕏,ʃI1 Z=QG-M_&x⽄=6b8~"!ZiKpS/*eg+FW&8(ISy(婼swWGE'7 /o{ŭa6pcQ2Ƀ3+e\8Sra9Zo0E3/5y&H7RfgaeHs1=9_2Y0{r‹ltDV1kt~f9{g>Οa_vaH~isz?h4c7xϫ3`'ݠOGۂ>'sz?hw7_">{.y/Ί29gF&SKO `s"nU]2T )%5%!L>TDf(8p'wʉ?7&鏬jNV9( >F ~DáL&J' *!#!1@]B@!A@!A@!A@!A!D0ABABABABABABABABABAA@!A@!A@!A@!A@!A@!A@!A@!A@!A@!A@!A@!A@!A@ endstream endobj 1823 0 obj <>stream endstream endobj 1822 0 obj <>stream endstream endobj 1821 0 obj <>stream endstream endobj 24 0 obj <> endobj 25 0 obj <> endobj 26 0 obj <> endobj 27 0 obj <> endobj 28 0 obj <> endobj 1844 0 obj <>/ExtGState<>/Font<>/ProcSet[/PDF/Text]/Properties<>/Shading<>/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1845 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1846 0 obj <>/Font<>/ProcSet[/PDF/Text/ImageC]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1847 0 obj <>/Font<>/ProcSet[/PDF/Text/ImageC]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1848 0 obj <>/Font<>/ProcSet[/PDF/Text/ImageC]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1859 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\034\002\025\202\001\025)21(\222 \006)-10(\026)11(\016\221\016\001\220 \221\025\r\002\016\217)-20.9(\201\016\001\220\203 \026)11(\013\222\025\r\025\202)10.1(\025 \201\001\013 \r\022\007\016\017\016\001\220\220 )]TJ 0 -1 TD [(\221\025\006)-10(\026)-31(\026\002\013\r\024\013\026\220\017\016\006\n)10(\025\202)10(\025 \013\001\013\007\216\001\025\202)10(\025 \001\016\201\016\002\217\013\001\220\205)]TJ 42.45 1 Td [(Pr)20(ognoses of injur)-30.9(y scale in sur)31(gical tr)31(eatment )]TJ 4.112 -1 Td [(of post-tr)21(aumatic anal incontinence)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0.57 Tw 10 0 0 10 42.5197 456.9139 Tm (\017\n\036\027\036\027\017\005 \024\006\036\027\017\r\026\035\026\f\034\ \023\024)Tj /Span<>> BDC ( )Tj EMC (\001\022\026\035\026\n-\024\023\030\024\f\027\017\022\026\n\017 )Tj -0.022 Tw 0 -1.218 TD [(\f\021\036\023\036\027\017 \026\027\026\035\034\027\024\005 \022\024\027\ \021\017\027\036\027\006\017\017 )0.5(\(W)22(e)-18(xner Incont)-32(inence )]TJ 0.13 Tw T* [(S)-24(cor)-23.9(e\) \017)]TJ /Span<>> BDC ( )Tj EMC (\022\026\004\036\f\021\r\026 \032\017\027\017 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\026\027\026\035\034\027\024\n \027\036\007\036\030\032\026\027\017\017 \ )Tj 0.332 Tw T* [(\(FIQL scor)-23.9(e, PISQ-12\), \022\024\021\024\030\t\036 \026\023\024\035\027\016\035\017\ \f\034 \023\026\006\017)]TJ 0 Tw (-)Tj 0.246 Tw T* (\036\027\021\022\026\n\017 \f\026\n\024\f\021\024\016\021\036\035\034\027\ \024 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\023\024\n\024\013\017 \024\027\035\026\005\027-\023\035\026\021)Tj 0 Tw (-)Tj 0.121 Tw T* (\235\024\030\n\t \004\036\030\036 3, 6, 12, 24 \n\036\f\016\006\036\r \023\ \024\f\035\036 \r\n\036\001\026\021\036\035\034)Tj 0 Tw (-)Tj 0.037 Tw T* [(\f\021\r\026. )0.5(\203\017 \024\007\027\026 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC [(\023\026\006\017\036\027\021\024\022 )0.5(\027\036 )0.5(\024\021\022\026\026\035\026\f\034 )0.5(\024\021 \031\004\026\f\021\017\016 )]TJ 0 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\017\f\f\035\036\007\024\r\026\027\017\017.)Tj 0.131 Tw T* (\221\021\026\021\017\f\021\017\004\036\f\022\017\036 \030\026\f\004\201\021\ \t \002\t\035\017 \023\030\024\r\036\007\036\027\t \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\023\024\n\024)Tj 0 Tw (-)Tj 0.02 Tw T* [(\013\017 \023\030\024\020\030\026\n\n\027\024\020\024 \024\002\036\f\023\ \036\004\036\027\017\016 R-S)15(tudio \(R Cor)-24(e T)40(eam )]TJ 0.076 Tw T* [(\(2019\). R: A l)-16(angua)-17(ge and env)-16(ir)-31.9(onment for st)15(a)15(t)-32(ist)-31.9(ical )]TJ 0.286 Tw T* [(com)10(put)-32(ing. R F)10(ound)42(a)15(t)-32(ion for S)15(t)15(a)15(t)-32(ist)-31.9(ical Com)10(put)-32(ing, )]TJ 0.563 Tw T* [(V)-15(ienna, A)10(ustr)-37(ia. URL ht)-30(tps://www.R-p)25.1(r)-32(ojec)-16(t.or)-31.9(g/\). )]TJ 0.264 Tw T* (\215\030\024\r\036\007\036\027\026 \024\006\036\027\022\026 \023\024\035\ \031\004\036\027\027\t\b \023\026\030\026\n\036\021\030\024\r, \022\024\030\ \030\036)Tj 0 Tw (-)Tj 0.029 Tw T* (\035\016\006\017\017 \n\036\032\007\031 \023\024\022\026\026\021\036\035\ \016\n\017 \211\003\222, \007\026\027\027\t\n\017 \024\006\036\027\024\004\ \027\t\b )Tj -0.028 Tw T* (\001\022\026\035 \017)Tj /Span<>> BDC ( )Tj EMC (\023\026\030\026\n\036\021\030\026\n\017 \023\026\006\017\036\027\021\024\ \022 \023\024\f\035\036 \023\030\024\r\036\007\036\027\017\016 \035\036)Tj 0 Tw (-)Tj 0.034 Tw T* (\004\036\027\017\016. \215\030\017)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\r\036\007\036\027\017\017 \026\027\026\035\017\026 \022\024\ \030\030\036\035\016\006\017\005 \017\f\023\024\035\034)Tj 0 Tw (-)Tj -0.001 Tw T* [(\024\r\026\035\017\f\034 \f\035\036\007\031\033\013\017\036 )0.5(\023\024\022\026\026\021\036\035\017: \024\006\036\027\017\r\026\036\n\t\ \036 \023\026\030\026)]TJ 0 Tw (-)Tj 0.079 Tw T* (\n\036\021\030\t \031\f\023\036\b\026 \024\023\036\030\026\006\017\017 \017\ )Tj /Span<>> BDC ( )Tj EMC (\022\026\004\036\f\021\r\026 \032\017\027\017 \(\027\026\004\036\027\017\ \036 )Tj 0.027 Tw T* [(\024\006\036\027\024\004\027\024\005 \001\022\026\035\t W)22(e)-17.9(xner Incont)-32(inence S)-24(cor)-24(e \007\024)]TJ /Span<>> BDC ( )Tj EMC (\024\023\036)Tj 0 Tw (-)Tj 0.228 Tw T* (\030\026\006\017\017 \017)Tj /Span<>> BDC ( )Tj EMC (\023\024\f\035\036, \027\026\004\036\027\017\036 \001\022\026\035\t FIQ\ L \007\024)Tj /Span<>> BDC ( )Tj EMC (\024\023\036\030\026\006\017\017 )Tj 0.068 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\023\024\f\035\036, \027\026\004\036\027\017\036 \001\022\026\035\t PIS\ Q-12 \007\024)Tj /Span<>> BDC ( )Tj EMC (\024\023\036\030\026\006\017\017 \017)Tj /Span<>> BDC ( )Tj EMC (\023\024)Tj 0 Tw (-)Tj 0.121 Tw T* (\f\035\036, \030\026\027\017\006\026 \r\t\001\036\031\022\026\026\027\027\ \t\b \001\022\026\035\), \023\024\022\026\026\021\036\035\017, \023\024\ )Tj 0 Tw (-)Tj 0.192 Tw T* (\035\031\004\036\027\027\t\036 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\031\035\034\021\030\026\r\031\022\024\r\024\005 \007\017\026\020\027\024\ \f\021\017\022\036 \(\030\026\n\036\030 )Tj 0.123 Tw T* (\007\036\235\036\022\021\026 \027\026\030\031\032\027\024\020\024 \f\235\ \017\027\022\021\036\030\026, \017\n\036\030\016\036\n\t\005 \r)Tj /Span<>> BDC ( )Tj EMC (\004\026\f\026\b )Tj -0.076 Tw T* (\031\f\035\024\r\027\024\020\024 \006\017\235\036\030\002\035\026\021\026\ \017)Tj /Span<>> BDC ( )Tj EMC (\020\030\026\007\031\f\026\b \024\022\030\031\032\027\024\f\021\017, \030\ \026\n\036\030 )Tj -0.012 Tw T* (\007\036\235\036\022\021\026 \r\027\031\021\030\036\027\027\036\020\024 \ \f\235\017\027\022\021\036\030\026, \017\n\036\030\016\036\n\t\005 \r)Tj /Span<>> BDC ( )Tj EMC (\004\026\f\026\b )Tj -0.07 Tw T* (\031\f\035\024\r\027\024\020\024 \006\017\235\036\030\002\035\026\021\026\ \017)Tj /Span<>> BDC ( )Tj EMC (\020\030\026\007\031\f\026\b \024\022\030\031\032\027\024\f\021\017, \021\ \024\035\013\017)Tj 0 Tw (-)Tj 0.067 Tw T* (\027\026 \035\036\r\024\005 \017)Tj /Span<>> BDC ( )Tj EMC [(\023\030\026\r\024\005 \027\024\032\036\022 m.lev)-15(a)15(t)17.1(or ani, \026)]TJ /Span<>> BDC ( )Tj EMC (\021\026\022\032\036 \031\020\024\035 )Tj -0.016 Tw T* (\017\b \r\023\035\036\021\036\027\017\016 \r)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\007\024\035\034\027\031\033 \n\t\001\006\031 \026\027\026\035\ \034\027\024\020\024 \022\026\027\026\035\026, )Tj T* (\026\027\024\030\036\022\021\026\035\034\027\t\005 \031\020\024\035 \r)Tj /Span<>> BDC ( )Tj EMC (\023\024\022\024\036, \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\027\026\021\031\032\017\r\026\027\017\017 \017)Tj /Span<>> BDC ( )Tj EMC (\f\032\026)Tj 0 Tw (-)Tj 0.106 Tw T* (\021\017\017, \026\n\023\035\017\021\031\007\026 \f\024\022\030\026\013\036\ \027\017\016 \023\031\002\024\030\036\022\021\026\035\034\027\024\005 \n\ \t\001\006\t, )Tj 0.21 Tw 23.244 64.543 Td (\027\026\035\017\004\017\036 \030\036\022\021\024\006\036\035\036 \017)Tj /Span<>> BDC ( )Tj EMC (\017\027\r\026\020\017\027\026\006\017\017 \023\030\016\n\024\005 \022\017\ \001\022\017\). )Tj -0.002 Tw T* (\003\027\026\004\036\027\017\036 Rs 0\2260,19 \023\030\017\027\017\n\026\ \035\024\f\034 \022\026\022 \253\024\004\036\027\034 \f\035\026\002\024\036\ \273, )Tj 0.123 Tw T* (0,20\2260,39)Tj /Span<>> BDC ( )Tj EMC (\227 \022\026\022 \253\f\035\026\002\024\036\273 \017)Tj /Span<>> BDC ( )Tj EMC (0,40\2260,59)Tj /Span<>> BDC ( )Tj EMC (\227 \022\026\022 \253\031\n\036)Tj 0 Tw (-)Tj -0.041 Tw T* (\030\036\027\027\024\036\273, 0,60\2260,79)Tj /Span<>> BDC ( )Tj EMC (\227 \022\026\022 \253\f\017\035\034\027\024\036\273 \017)Tj /Span<>> BDC ( )Tj EMC (0,80\2261,0)Tj /Span<>> BDC ( )Tj EMC (\227 \022\026\022 )Tj 0.161 Tw T* (\253\024\004\036\027\034 \f\017\035\034\027\024\036\273. \217\036\031\035\ \034\021\026\021\t \f\004\017\021\026\035\017\f\034 \f\021\026\021\017\f\ \021\017\004\036)Tj 0 Tw (-)Tj T* (\f\022\017 \027\026\004\017\n\t\n\017, \023\030\017)Tj /Span<>> BDC ( )Tj EMC (P)Tj /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (0,05 \(2-\f\021\024\030\024\027\027\017\005\).)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 275.0305 627.4059 Tm [(\033\034\020)21(\223)50(\r\241)46(\024)52(\026)45(\024\232)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0 Tc 0.149 Tw 10 0 0 10 274.9606 603.0499 Tm (\200 \017\f\f\035\036\007\024\r\026\027\017\017 \023\030\017\027\016\035\ \017 \031\004\026\f\021\017\036 35 \023\026\006\017\036\027\021\024\022,\ \f\024)Tj 0 Tw (-)Tj 0.073 Tw T* (\024\021\r\036\021\f\021\r\024\r\026\r\001\017\b \022\030\017\021\036\030\ \017\016\n \r\022\035\033\004\036\027\017\016. \200\f\036 \024\027\017 \024\ \002)Tj 0 Tw (-)Tj 0.194 Tw T* (\030\026\021\017\035\017\f\034 \r)Tj /Span<>> BDC ( )Tj EMC (\211\027\017\r\036\030\f\017\021\036\021\f\022\031\033 \022\035\017\027\017\ \022\031 \204\206\211 \017\n. \204.\200. )Tj ET q /GS0 gs 221.1023475 0 0 183.4117178 42.5196833 553.5962033 cm /Im0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0 Tw 10 0 0 10 263.622 553.5748 Tm ( )Tj 0.152 Tw 9 0 0 9 42.5197 542.7748 Tm (\022\t\217\210\b\002\220 5.)Tj 0 0 0 1 k /GS1 gs /T1_4 1 Tf ( \230\004\n\202\032\026\003\003\026 \024\032\026\021\t\033\031\032\025\021\ \031\026\023\022\021\n\202\n \205\023\022\024\032\026\016\027\205\013\n)Tj 0 Tw (-)Tj 0.026 Tw 0 -1.2 TD (\027\n\202\n \025\t\t\023\031\030\n\027\026\021\025\002. 1)Tj /Span<>> BDC ( )Tj EMC (\227 \033\032\n\t\027\031\024 \021\025\204\021\031\026\003\033\205\023\002\ \032\021\n\202\n \n\024\030\031)Tj 0 Tw (-)Tj 0.067 Tw T* (\023\026 \033\032\002\003\n\017 \013\025\001\013\025, 2)Tj /Span<>> BDC ( )Tj EMC (\227 \026\021\n\032\031\013\024\026\023\022\021\020\017 \205\202\n\023, \ 3)Tj /Span<>> BDC ( )Tj EMC (\227 \033\032\n\t\027\031\024 )Tj 0 Tw T* (\027\023\026\202\026\023\025\211\026, 4)Tj /Span<>> BDC ( )Tj EMC (\227 \033\032\n\t\027\031\024 \003\n\006\031\027\n\202\n \033\205\016\020\ \032\002, 5)Tj /Span<>> BDC ( )Tj EMC (\227 \205\032\031\024\032\026)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0.113 Tw T* [(F)-16(igure )0.5(5.)]TJ 0 0 0 1 k /GS1 gs /T1_4 1 Tf [( )0.5(Echog)14(ram )0.5(transper)-37(ineal )0.5(ultrasound. )0.6(1)]TJ /Span<>> BDC ( )Tj EMC [(\227 )0.5(lumen )0.5(of )]TJ 0.001 Tw T* [(the low)12(er am)16(pullar por)-40(tion of the rectum, 2)]TJ /Span<>> BDC ( )Tj EMC [(\227 anorectal ang)13(le, )]TJ 0 Tw T* (3)Tj /Span<>> BDC ( )Tj EMC [(\227 v)16(aginal lumen, 4)]TJ /Span<>> BDC ( )Tj EMC (\227 bladder lumen, 5)Tj /Span<>> BDC ( )Tj EMC (\227 urethra)Tj ET q 274.961 176.596 221.102 386.084 re W n q /GS0 gs 221.1023475 0 0 386.2689248 274.9606228 176.4108667 cm /Im1 Do Q Q BT 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 10 0 0 10 496.063 176.5959 Tm ( )Tj 0.183 Tw 9 0 0 9 274.9606 165.7959 Tm (\022\t\217\210\b\002\220 6.)Tj 0 0 0 1 k /GS1 gs /T1_4 1 Tf ( \230\004\n\202\032\026\003\003\026 3D \230\212\214\221\215, \013\n\003\005\ \025\021\025\032\n\027\026\021\021\020\031 \t\031\006\031)Tj 0 Tw (-)Tj 0.091 Tw T* (\021\025\002. \201)Tj /Span<>> BDC ( )Tj EMC (\227 \026\013\t\025\026\023\022\021\026\002 \025)Tj /Span<>> BDC ( )Tj EMC (\t\026\202\025\024\024\026\023\022\021\026\002 \033\023\n\t\013\n\t\024\022\ , \030\031\f\031\013\024 )Tj 0.025 Tw T* [(\217\201\207 )0.5(47 \202\032\026\030\205\t\n\027. )0.6(\213)]TJ /Span<>> BDC ( )Tj EMC [(\227 )0.5(\026\013\t\025\026\023\022\021\026\002 )0.5(\025)]TJ /Span<>> BDC ( )Tj EMC 14.958 0 Td [(\013\n\032\n\021\026\032\021\026\002 )0.6(\033\023\n\t\013\n\t\024\022, )]TJ -0.017 Tw -14.958 -1.2 Td (\030\031\f\031\013\024 \217\201\207 116 \202\032\026\030\205\t\n\027. \222\ \032\026\t\021\026\002 \023\025\021\025\002)Tj /Span<>> BDC ( )Tj EMC (\227 \013\n\021\024\205\032\020 \021\031\025\016)Tj 0 Tw (-)Tj T* (\003\031\021\031\021\021\n\202\n \217\201\207.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0.137 Tw T* [(F)-16(igure )0.6(6)16(.)]TJ 0 0 0 1 k /GS1 gs /T1_4 1 Tf [( )0.5(3D )0.5(ER)27(US )0.6(sonog)14(ram, )0.5(combined )0.5(sections. )0.6(\201)]TJ /Span<>> BDC ( )Tj EMC 21.314 0 Td [(\227 )0.5(axial )]TJ 0.166 Tw -21.314 -1.2 Td [(and sagittal plane, defect ofEA)50(S 47 deg)14.1(rees. \213)]TJ /Span<>> BDC ( )Tj EMC (\227 axial and )Tj 0.124 Tw T* [(coronal plane, EA)50(S defect of 116 deg)14(rees. The red line is the )]TJ 0 Tw T* [(contours of the unchang)12.2(ed EA)50(S)]TJ ET 1 0.68 0 0.12 k /GS0 gs 274.961 540.773 21.907 21.907 re f BT 0 0 0 0 k /T1_3 1 Tf 11 0 0 11 282.7075 547.739 Tm (\032)Tj ET 1 0.68 0 0.12 k 274.961 338.94 21.907 21.907 re f BT 0 0 0 0 k /T1_3 1 Tf 11 0 0 11 282.7131 345.9061 Tm (\225)Tj 1 0.68 0 0.12 k /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\033\030\031\030\213\b)-20.9(\035\231\213\233\t \021\032)50(\b)42(\032\231\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj /T1_5 1 Tf 25 0 0 25 512.8394 56.0378 Tm (75)Tj ET endstream endobj 1860 0 obj <>stream Adobed     '$''''$25552;;;;;;;;;;   ####''',,,   ####''',,,   ####''',,,""  |!1A"Qaq2#BR3S $%&'()*456789:CDEFGHIJTUVWXYZbcdefghijrstuvwxyz!1AQ"aq2BR#$Cb %&'()*3456789:DEFGHIJSTUVWXYZcdefghijrstuvwxyz?5;GZ*7_$l2_lT?X= DnpS*RkkZ9\d$+]79s\\, #Dקy xgc 5[)?> +q p!7@34rtŰcֳ c@kZhPlI! HBI$!I$B!$IBH  GiX)n;a}r\]!nۚ6w5qpm;E׾ppsřwk=کbaaqȝƁZaY{^8 0>鹹#cݨ2e5 =bj"]z'bDi;i~>\C%l 3CNԔ7yM-T?smaٯ^D 9(0 <2N& ȃlpNN7S i?Zx2&R]\TVWRG pc|VbISj@*I$!BI$!I$B!$IBI$!BI$!I$B!$IBI$!BI$!I$B!$N %IsPJ^6>lFaz'4_y\;G'+ pH 2DW y8!L2Z'G5nzWb0 Ӡ5Ah@̕2<^ ,-Sg !w6t\V c08;-4WI%JaBI$! $HB.bTxmxN$wy(Bxg va]X x~>|F<<<8oMpXUB~,. FQʹ^PԻvsRgQ-OVs̏ivħ5CSǂ|<·n'HֺA˒V"N']@I$+BI$!BI$! $HB$"ITپHBӆ5"EOa:K̇Aװr$k /"$n`{)qSWXt ÁT{\s (JI.#1100Y8|[]bM4+ى\r,]mlPRR\Yn#$|%ͷ$Dw56 )Dfo#] sE:wKļN,oޞ˷w(Sˈ:P l'i/G+AI5yW35 [;f+C42K<q< "6@+%JdpzJ.Xt$zpk7' $ͳvv[`{\N*:# Fҙ"V5n0y 3(tE4sI'R^%!kcU˃B<3ƐQ+ِdž01p2eH{cW&׵m0? b4 붻p;FkD]I$Q B fxC -pH}h&yA$I! (BI$!I$B,$]` !e w.p 8tNLE3=5iqns 'W]S) CwJڡslx&Hn#Zo6n)ˁpl\ؤi.FJbJ`Ɔ'~%qg X8S<*q5xIgEo? qpw8÷avÝ\q ;\gʘfE3WA9p#"#խn{o,J︯6 kItܭ0s:%AZ7͗8٣]0{Z 236W84 ɒhD&bGWKsh-H %StbwF{ΪHLcG;;q LI33 d4$8b5JK[&1 ZVIP,yfyAt]+aܘ ֒L(VZf;gIhI0uP$A/2i 3s2z1wqؚ㳁>x:Ⱥiӻ ݊{4!Shv,-5Q#qcre=qwMp5lm\G@'H=I)|nk@;Aux~{aqkL) ltN9MIv#r6B8"DӝvBKzۜGZ#H g n,b0Na;1] T/?|>^d.u{F)29I*w` 0ـ Ix]3h\apoq nj@j% .񲷤$.UZ ^ X;pGa̓b:9Ё]LtIN3̸ӉI8CA v3q] Q6qcaG\﹵f;[ 0g)s0G$@8iqԔ6D#Z1)8%=idee nsE冺Ȏe+2dwPdd+Zљql%XM*Au]zdHq3 'S i:! ӊq/ѫAhhO;ska TZ0l2;h'eOGOnQSl$bzjا㤙S6g7kvk:Bs|uXlf=5%jMfd@uUbfTv0_*Jnl%p^5S*T.yP%|>!0 {d7gREoإ%vX­VHu5}k:xCFM v! ocFI%VWN!$IBI$!BSѶW&vHB~flaqC6ӪzI$+BI$!BI$! )i;ݠd;6gL85  N9cKCZI&'`4>s]\0=0ͪ|xc?5O-zG֠'`=mgiQFZ^ ;pdak dPM7gί{fơ`-ƌ,V39٨, #.X k2^i\ #5y?xI 0:MX>®aq~3p`55/p6=U|×\qGc#zkI,\\؎ F$D#CK\a$s5hr~gEyfqcpS|Z늢)iD]e4Q^1 `4j qn ZAFT||nԗy7r !s<3p i,H:W@usIJYy6׀_Ctե9Òu@˵=4 e{Q=_W%qagSZڧ2́# CI';yt4arG*!J ̄A> 0]DE8u m d4>^8h}%imϧIh  PaQy8gWgHP-$XZ_ p&Å%qiW (%y[kRWn be~8[eӢi=78C"0Bg-T B}W-UHuJ/$e 0@+!5YJ8xa~&|\"OAv& c uXӵs răk?@Lg+MUPm&Iw ŧܦ la08tD'xCF#rCa-$I(!BI$!I$B!I$+BI$!BKeq[4%E<,>oܰi ~78\n+r`a$ƀday׿E3Nw]eX˩b`5 U \K3P)f6烚r#z}gcG[ 6Q\g)GqȊ@7x z֓묿'.5dJ{U8~IZx8 fT(%e5PA~dȃe-8C& hF/x?F Ya\:FskFDv킬9T*\'5t]AcC]I9wk0 $K*;/B7L-ׁ]=fW& k\:ɞv͘ N&'gQÜp撬9΀ؽj+$F ؕƨ+N\uj H*ܨjHIiKG"f`K4یvjVp^'f‚f+2u0\ keY,qi!hʄ_$䠷Ӻ̷w8"L[}nK .'8nn ۋ؍!z) "^2 3vA^/[-`lP 8/v^ {՘wi$EIzI$!BI$tc":2D`P! N7I#7Y3\I$+BI$!B}*|cN] Z&Ҁp Рʏoy@sf@CPipwkatm:γVOTqHɃ}+K[:6 8#~.)'2m JM"q.8xčVk#ZN&WXmb6Z$D˛B!eST8p0:<|[058DPc$tFbyF\<>6u[M3%0knr[M/iT-6h:5A+L\l`45/lx8bH@}UWǵy ]ʫ)4#TlMUk+0vvⵣ0lsNc3"07S.(\HK_PFf۰1xx;;H->ԬtsKh &pE3 @3s9/lKAn=+fS.pst}i˝0p.2%B-/ik f` k/@ ZӰz- gK +0-p&ux,lR<{2Br<<37`[&:Z򨹸X8b A7 ۠8* Z 1 xTw1+ b^CaWACK.ع $<Z+u|>>0>5zMI*3Ȭ#\ Hʫ#,2%).(e-K9pѲ FIƓqt6[xi*~ jלQAG'VtCXq^IרZ^akFwLJe{.aft@D-і_y${@P-vY 6?,ѺGL@3{72e~cR2 N`91՚ؾHy! $JP=X+^pic dD{sq1RH.ڹbc8浍H@SGz\Gh8D!S+_ebaY$I&frW)0fOY8CpJjIt-ʴ-v&1p9DOyKdM*F-Qڏ%%jjfXĦm';J4;PhVXч:G0CpeZu2t qQTIBն[^39miՌdeqi`\V6pryUH_Ѻw @p;?gbh$#ny@gGF}{C #b %^f7 hs^ ApBI$YRBI$!BI$+BLvǓ `jlVAvs#uw to0|ǵ` [D=ܬ]666lWa0:I>4>ׄ18fkg.IpN@i%hRw}nj1ńh׾EfD2%AN %8r4`dBUlTV){ +.qq.qwXTRI#?pj/+_+'X[Iܠ<6tkt@<w-&ӡ]  iAFd!W/;NkIxޡY1ZxlH` }Rφ @nfvWy߇s]^PpK~~z6JLƼɊ嚅&-; ثqY;&+XZ npɈܽp%N՘F&)-.CjP-ƙǾiަ\^ hLB;b!߾5GJ-zÇ 'e¯Xm$oe&pRѳ^j[B-en.4c$q3grKcro%8cNcy; 9F3Ms02pO-Ͳ.B¹xbl.q.bV9 eD; $8?Bs~ bҨ7nVt:dyak6 9pHvkUS\3hf&y+pNdZi|Y} mK3)0^7rA' 018VChIs[p eę}s/ý!W'0|^1qْ&dܹT[evxXg]c<3f rhxn'8 pi{&16\&spmg R@HQ8:vN,s\qndnɍJn8 N ΰ3Ž{U&r2٠ؿ)]"Dt狏H;$.1Y3:hT03zP\Ѱ]fJ@>tQQiAi8?x Jfoj:?78Ѳw!5·4g!M{OLP(41{\^⎓$ϸ2 R QP )%@tE2t=|f`/kXXA Wx%8~n_l.;-lZ_932` EC+ptOV0L|숌'5i`tvS[EZԼ4G%!f l` :r8oR֬JBXOcZ#0CiʞxgazyM eF`jݖ7-袡HbbպTX/ !Ht9oL8N^Ǖ]c▜B2t*MfC]m@I %7X>Wp{m-fX q{@|aˊj{49L`rP%en]q-"I . 6761j8f#@Ȣ8x oK-u zs&SS;bJ.x`? Hؠa3-HlVϋ]:jR@@s zjV󀁁ܸfcSSas]JK/sqYv3B-y@gű/2@KIYÅꁙeRn` ULμѥVZAD4ZT5cs0Z(W1lL7b9WKi<-Ǵ4,4>MVXLjqs ڶ E_U_Fo BhTԭMT9ٌ5k%6qͩ3 ΈJz5Smp.rbS^_8'c0b s+NJR4 4PRaQptpJT-iF#\QN 3?N{Cd. \Kݘj"aظ !g$@-lԪZjIQ[+nV1th;UH'MK3fi870t Ko`x=Œ~-5M49ۻS٪ƚ7. f.#Z-N`{s]熼Ae.vcq8,L'gq䵾+`m=GRt7`⥱m\h]E]%7#<}GI9%ul` k9s[D8WU;%\=+5Ә`lq p2q4K1 s7cZ6텑`8<ƀIZv U1HaPߨ lIemK^Xf".eT53ޞ)K6VZB# i$qnsh5ܱ2EmsnP=}AIe檊 N8cSϕV09O:!DibMcSZ:+JϦ\q'_I줌E()u<漐9%hh4h"GH Fki/#=u1\ ڛR 3tq *41kz"GIa$,K&PJXg@O"څF op~wJHXBhu9QVZ:Vi42vX!BLMդZ*RhifJTNC7'yp &bB!V{E4Z`3 acirbH[U5&X)T894b. |gѫh& O ! WP8\ni0UFj9%g-ֳVDpt#EV*u-Ux< L^,GhnLL6({iOiBknn#]*`΅djtl6[+wɅN7F啬s 8>bq!k39( ~3˟j&;3tq<ҮL괩Yasdƫj>2Ci*cٛ8.CEA!b[o{[dg *Lc %vo]*s;k53VQ{%On=ֈ߸JA:{tX$uzz/ցnwa+2ꢦnH0bd!&aM;-ԜIkzu@91;v+jU &7ysIv䴩Z(ڬMjptYw3՞z ,q2EZ6# d$VكN9 -ApD!m!&H'S R\OCF;Xx2.y E٤bAV0$ BKdLLf6/#iِ޳Sv&fIlMwžCKC0HHjO6qV[8jnTqA: F+/v0O؍Ixcf3L:W;7p]6 CytKkp. IiLauNFi aSק.p8>W1 DXXYᆝ)xrh9{ h; 'vkba ?Z<,cɔ }E!DϦ뽱S5dft\ʥ?H:F ][8v*8cqk0\@OrRClBC.$CX!T :$gBl)>jkHxFJ qB *]8oIXܜ$f^[Vv`kN|C&jإ8@Ȉ'D! `{jV\cM9LrLekD; &YEHe`KH䬞w[8PhVgmgD㌨,@q8a ͦ:p1ܧӧF'9NDB'pQkz蓐 V8TѐrKg^D96! 3ز5E 9RZQq 7oF-Rl{%CZ^X$!bn c uOU$ U K s\oj a.$l쓦k=ɂrTNiҳ OY`AVZݳWjuRmGC"F2ul|z7аRyXTf3rB=TL 29h\L\U]Bo4Behk9z7H9G+fSn93Hx"q: Unp{XL[i^s HsDK%.ձ7dȼ 6:|4#aNxZf@aGR[St(f1Q%56{'en?|'eHh4̈ :"׈5g٥v8P29&g\xwyb!j2*,@:D,V׀Z~kT0 P>o $K= 0ʔiȓ戂Fa[Zp~@\17ih,`H'X)ldΒDU kqƫ7SM]ʯVJlxV-͝\4w*[OTzZ'+yɷkYSl.nR4vS62iqעC M!K|h'18N`rRl o:zKqiϝl`S[ߪOmDr*êˍ5*7S8)~# DzA]^:6Co66 v fqXxG31X!x Lq^]@^q8n!7Xp[@;ot@ L]#@ޱ\,5E^Wq t1,NHTc #ś݊<m8{K-~1!dD2oIsмt8q"KJ+l'k6 Z>M<=_m yhl7d0pgRR =qiinKx<07K2Cr&S8w N#3X]@=Ytp8LL/ 1OCqK\o+mވ.V c5nW}V–fER&ת$d5KM`S|Szaꨐ~;ߟ=b7#˸\'|npk]Ӣ`-Ҽg_0XLaOh c g#|0K:cda#5mvۦQ8<[<W- <~'Hj9O0^s3 1M3 < +Ͷ<^m 3XPڟdӳقĴ5(?XG Ӟ_/XB=ô֍-sia)F BkV.0<[N^9hQ;Āz9g|6aa$#8P F<<"p% ޷Cj$ʥhmJBhsFAf6 `5[]>䳪 #Ip2Dy!Ae8Ssa +60Z q*!DꧣR--a`!45lNWfvA48q؍ʶʏ4fS4nj6ZZ 1}L#rHBl[K\4` 8PnAw6ӝCn|u2#u,mV/pEM̝ch[\9xy&Ԩs2#Q+ipÈ+ȴ BݻkY Ĺ [2G9;))KARӨEq0w(.)λ+!a)ŖsFΝg? ښ7 }Zwb *u ƅ/A$`eH5Ë9H)Y^ʅPRɢp 6w.P KL P#ė6Ok'3r>2yytegdb <³B-.cR l|>Pi@%]UFک\]3TR"dŽ[6a=)-'HbAy-i,;N᱉H"]/9)%WSuZGa [p =ci7b 6zOHF# ]ihé8h>^-a5T~zH[zr"/5^axOsKH b V$fkMYAy 09vo=Aq+>]m0 a YŜ -`D E@ѫ%,,ʷXCd:,Q8˲R-JZn~A ++ Mv[ױpP6e9^iK{RZHM>Jb0Rf!m-; m 2U;ߟN]9n2qac4c 5I1 '/FC0Vci/~gē'u1DO@jWcĸ'݉Pv%bJ3,qXBod+:I\F<6F2LrQh a=iM5X_. ƾE/ϑEQʄ+ Dp!<(0b0fА$b7WYMրZaQ mWCfDݢPnʐn͈Ht&( O2vU#!.v!DǽgN7H4Q^i%ω':]1P%VTqY:e߲h`CpC8=謁.cK%l<ɎCrv1=$ڵn:;H%"2F ͩpl6sB(e t[=y$ J07KF@f(dH3³-1jFĶ6aLc(I H7"+7 uUmIᄸ / a~16qz7(sD??04T0Ȱb Lϩ R!+̯ yˇ|!k!4[^ GIf m\snIO$I+! $HB$I! !C"5Y3-IFͧ~q{(P.ӨN&+`y&1V92$.S6+Qⴕ[@xb{Ѧ ¸-cN[:T)ZQP+tj&Ey#ضRm\ '/ߧVž}a9H -6. p6:aTEq3`6VF-½Y+Rs\d n-`qNr8sb`̙}\8Tp 3cXrh[JsnCLj2CHߪ̡jtXWb05؛@mgEDN],tske%NҩC"9v_ŴNݢ}p~+s.{g1-Jt(iyr*欲3L*t^< -Zeh́\ZC0?+ B' n C+SYT}w(41~7hp6nItp@Q+3J;ݏ:eÉi2Zqq:0[5cpl՝ ɓ/wD'8! sDݞʥ/hq 5CsKOh5ņDw PHݙZ9F P~wZ*9LXUB!XFrzfi8+EՅH 3; 8)kkdYRU" EN(K,'9cUa48\`L¨3ԫg6qNxǓuj=hcNZ+ZY`R`q=T:xR/ ĭWcvp\#81>V;ַs>]=O]Põi+8˞5`~E#^K`ȜTx&`f0Mh)nNp2k:h^fpLE5P߲U.}9c@z@UV$^*wSu)>x{3 )}V!MD9oJW8MeZs2`_ai$`W_x͠g љmJ{CZ@qrqfsF}t8A+0G= 2Ӏ8'{h nSC$oLgV312"}_U|Sa9ᅄSaIhMca9qrsbfc]f渔pQqB_9-G[N ~cƱ@}}R8w} LyA>ܻ{rI$Rv{ՁA->µ$IaBI$!BI"fƎvAuNbF %~7999k%ByeW1.rCl,2='w סI&V!$IdBJRvP|-8+zk*yRi:H5 ρA>dk{#1A\3́,:enjFlW u[oF8yet"1Xuڮ\'zkU嘘g ŤG%vX#Iy,Wq7f[Y٪H&(ױ8 :pTuZo1F!IKhQa:~@ۚ{t^ )֠Z2TV炚9$q v"$,@-*n4AvzVNI),D:5[sHj'E,1Dqܶ)<bo7Yڃw1,۩Q!zhFU3vfoGD~㤵>yƑc<7{%ɪuZ]MŮtr@eX2q5e6feX3#k7PT9h}SRxc{PNapx1=P>R7~҅G c/8Oo ]>|'w7m$Iy{k. (p鸨_t8xM젌\ݕ^ Ax.,=p1I&s `0p\G:MvhXaj H*Xq/$s-!U' ұj Dvkk=tO{xF /NNnqhU&]#yW(517eZ? v+NoMj%O&w8N/4My[ܨdrmq`l*pZC):^h$bs=ʒ%.`Oq(,6hթynM}'T3jg!\ wMta y"VX1lByqLn[W7bOu3hY-];+o9^H+y- al ĶLrw)O ^s1qxp+l"mp)0კ$=41p c d&@ZX`IGe>DCyuxl)X5 >kjZZ Wgsaysu$N`pţEpxym򸒇3}M|/ `|R:5crv -{:ʁ[A x*ȚXqH P;ܿfp qn=TҊ APgAN5mFaLwE2H7D!Y^`Ϭ=4wBu|>D1߆ Dvު90p̧{$2B1w!Y8͠!U&uq>8< fUIl<Hv*S[ܪ]L`ci&qwdΉ~|qDW}pp_D`lH7pchDSw -s1u$Tf &*036hBՀ洸NgT&[CW=)Ma0іDz?ėpX 6-U\l3-Iݚю@VV8r? ֽm8|<<\v)#WZpL "wXh3= R@\D a8|< $MG8o kqW0qz:Ov>vg8q/" ˅ fPo Mp&;>)yKv$Z\L& s1)i8 25 B#i^9ӉeRiq.l7B1;j67FN'Se2[Nء 1*HI갲I&XMemVqaPPD:vReU1ʴo92/spGֱĝI=dyE+K+kA;q=^UB37W^]D3@vQ(MցzεcunF\=*xCYXBe{ßH*.و$n[{#'LUؘiV̅k8l?I/ qdd .%I,ZdQz&rE|d3  o 2ev O(-x<"C6OTSz8/ ;W6Q0q1sb0ƚ,*ф$5*`kT. NŤlNhVs p8n1{ ijFelG1D8.[‘uvNS@ dJװ։pcPV$HhZN81 8%H]&' qcdpzRN(q&+)YwDPi P״2l8aK8/c2 *: nW< Zx\g2@[IAgm/p,4r\Ȣ ex aaf ǧcp_K~ Č7hI5Mpv.nk0'+O\apҶ4 ߚ˧Rܔ8mCy/99-0ļe]8ذH>xXzmhp4ǰ*K[I# ˵Y}MB_a 0D8Is4=Wt/LN#À6j}tjip xjQd̨I$7/~gIv=x,b7 G &&a,H>ꄙsp]5$.1v'sZǷgJ1HUpq A lWpXo$z[;k8{0Ty{ˈ%|@&l.eo1q ^3b,p8FV1цϗUs0nGڸ>quGknbJp4JU /pa H-`[0!A;8C,4/I'_h&G* ר' C[jG_I*|b@t I`'s517=7rn kd=Lro $Nm&>KpRn> !1Y} 8/  :98 90\ZFgؘCL]AƲ].JBom83qjnWp}0_P=0C Imr7 pL<3N@Qn;ssK#0 +Q>'!1]6]Y:8 65ٚ6J4 w9tmM:ﰎرDp sq<'gqYay `-~TYoDYrAGzv$8<<@ ک|;(vPb;? $yVߋb+ 8L5OE4GOŗ6uoUn'[pm{-1N1)q8nq'<3m nPo..H)%>p~i.3`M n 5]-:AB#%c^DQB1$qs~껣;߶]Øz|Tq 81̔+1[[ ppݑWA^ BQH햅puWN% ~ʕ XwisX  "VYD)[s1uX.VP%jgDS)xW\>'l7eA:e#^O`aa mV8A;1/> Bh]d8¤c5Gry֐O'❝{0e=UᰰjI$z-p1Lxq0wfpbvڮ^)I&l2{C =AX8&uH$fԼȟt~p0>0ǰ`րaaY.avIpZ,IB1<bu,Xe&X=;) L,u1́QgFqUļMWg@..$V>|@+F|hb0:_ⶡ7[|G܍͐I<⛀Fz6V#v%&85ݔb O vbKb<)Clrxu1;`S$I#R[" ZT\葆+48r_:& 流Hg1"o'"]OdG}Ť_yj E֎])Tmn"1,+=OɇSڕwĸBcAQh1*C&E=>5;U*@oL*㊧蓔 7֦\M% %RI}b[.Ozg =Ҟ+۔65r! .5i:hNZ! ;,Lna;IPGmk*VPCe]tlMa;V;}1aD4!BFL@ޞ85-k o5Ffx5PZ/sppm H!FT! KH!Q: (j=!ܚ eG`Y< څB) [\؄Z\M׋:!ʛXwX$!Bq5K<'Tt @Qb n9,tX!Pԡ4TyT-;UFvZ f7(8S!afF*9RfD|TZ哗B]cp<6<H>Z i bFUl75o1],DS<0^,]? Lj;f<;spM.qK¹XH>Y::YEPޑQO3Y; ŵ#=#8HL<3{+X mN5:\CatfIӸHZxe~SlvAha!4#$F$q 98 sNi'<ˉ{BW3"3wz';1'䢄,U!pR4k1q]Z eZ:zLn9J,hXZ|f3 Z yVu4z[-| A\'$ h.=ӥ<ңurꀓJ 62ZqVp]jf=2gp\ ǾЎ 9=hd{*qX΀oVY`sDj2O:q; >p(ilbֵ;v>rf #6S'Sy9vu).851~I]k6in! ;QE^!˄dá n-1'&%}Xظ\B>$P1sSv KU n@jBQB"/ 8ׄp:+TYȼZ xM 8gΘim& &;{Є!@TyAЌ\vݒaȗH#l7P%B' #E! gPk0Ruh-y G7bhBKNȍEja12 5 S-Sy ,HB֛t*CF21*g @l&V !dzK%Ѝ e9`W-Ӈ5Uk9ژ]u6)Pk3ft5k:8_zVtwn B̴U#%3Emׂ,H% ' .Тx7G Rp)o΄Yk-1+| V ZQP謂rW$ ØVIx$h.W=@B41x(M 9n+X6FbB>!"Z`ؙV=DoK(Q%_<-{ =֜cyGF٘YRL$b0|a]Iyl=d FK=s w$l|]:#fe*zRB%}`Sp!7O ^yhp eg`?9:䅄ZCL=HOa Bf ̅V00yN60ƹ`u 8X׸}}d 9yĪmDӊP0=nUx/Nf:MyVlHh]._k{@- v|]A&TbI#QNd I( vcᱭµֵIx{[,n H0`)51obf1Tr WL:jN wBq\3ZI{셭$ZFtXw aj1^p x.u ugf*{480a8x.u}RxG懗u x;̍ӱ]$:PpQ b*0^ƌ6567*1 =j~atGq>>+eI+ԃ tÚ+kqq^## s CcWHnc$Szk}af]w$rgq:8ϮC @<_X`zKc@i$IW0P= VbHf!lnEOmh܀\$ ,!"al['ȗ(n#4vM \I`7(H-aaH޽ҿ b:FBW45shNa ˕Li'$֗ƜB'F&Qj/O,GUVV\n h#`:t'Eze&IN};aI;&p8GIŗI-xKO%O (!]@88X,#@{hZqK$YI. nb>I'eoOq*共]gyNbS8eta%d*FhnnʸU10=m\BD:pR-Kt%Ƕn`ieʴTqp<P_vZvr[5'yH 1s5&eZ>qpDu[';4WHu퀵_q-` P4}wmb7 %27TN`s7*eyh9y8XZZ4gZj%f>!o&,Cч1&\١̐'iIŇI0}B%4AktRuN\[-8oLnc;ɀSkZlA]Fki0ۆ pc@KNVL'*RˏySi<[΀8#TXB`xcc}Թ3Qs' TtR㍧uiAX%rI k *' wln].nZĨ Aш7jUa$n8^瓋@=EPkNN1zp088ڀ"{ jfsG(>3-5 PMܺ+k %e'pD5[/iTƒ[pxnn~+{;y yjKv)¦ZN$)dX W`d2=eN'A-oS+kq8-5 wBFmsL<Ֆ<6KTuUf1yT#RmÛöB z&2Ϧu Zaq$4V2wsaX.t':$81+`dv#Anc`itoaa4B!UH/-ke;FI0@. q74k#Yb%tP'hT-~ulgօp#9)cn5;s}!kg%3R{PUcxYa38W:8 F=x3 &5T|=JjPRQshAд'u'O]np1@ ykc\J'觴+08Փ%IDQk(pAwy}54<µA v3q)KV} kGKuX}o]eJ[ӒY B2 .Ի4}k a`#W|DJy] 47+ _9loި83!1WcqZ;cSX=YNuZm"]E 'TnV,./!/q׿H(^LJbN!oYƆ/>=A>.mu].s)9H9,r..w[2;Z ßrd_$ ٠ 3%<@ J'{ƱL0cs k0ح=%+u hl煮: K4S ztD+! -N=Vowp1ܸp}Oi%\0^KTcDrKr+Qt]k\t0入{=>\a\>\g8h ||l7@ tRP/mZaMUz cVJ8 tOlܭd5ڨ^`!UG0 qY8{oD41Pڍ:HVc[N.U:Irkj9ƢnV:'a$.B@آY`HgHVTIP-#)Gh&$((@tDxS#)t ,kBN21fwZP{ `:flX =f@{p(tn-?q^upUTiҸꗌq 00!@,1Z0z9S' . #rDRxC88eOxqxτ=J .b]1'``9.,ݧOIgx.#1;hWanI_pd1N59'3"ap />K,- o6H=ګ z Uc51Ic8.4~4ˌ<\zk! > 9c\ BżF;VDLA-Je-\Y:Li{+RqL-$Os87h) HD!]`c08$)UXKu`eE7F]V8]U%8q*Ȍ,gFy4<Ƴ%عO֤JBys(Kq~ 1 G\9V-L7()h6H߂+ixEqMhRsLe%TlG.Ȣm5Zi11Y$תU蝚y$: d',lG9 ԿOMv GEHyF# x?4 _Zo٤*i)JS.UJF\x#CWL ]?\ |v1'(ԵxXy3pcJiWSQoB5 A\o 1`6;ɘcL7fp8J*tA>[9bHPAVq9T$βpH8xTE8'ZӤ}p`3>\Ff@[abb3ᷓyH< B/c*'bn/C{G\x'W0 Gla 0 tPkTyaH+LP&4d*xV 2;tkq`h@Ҵ3p{s [ b'Uܗe$RJx;!4LVLlԻi]s$v4 fi$./C޲ k5w.0==RI,J"=}#;GFg:˜9lf7*3]Iܗ% YVr|n>;C'F7˯.n %)q!84Q)$8xa:pxP+ᣍ&f -h3^V6DNP =?1qqw NRdSJ ٤>trI#,-<1 ^i, q^w<;6p0\#M; 1΂5kYƩ8[L;S@' ;(B1_8i>8bKF{ua1q6虅\Eu[;^Cp7 Ao8v ^G8w 0lF:*`xi6G I$3(Wp=#ĵiy~s>Hl8o,s,q\AiI"bT!hi i9&{JE3If$\Bu>()`ެ Ut]tkV)tLNH/< Wbb i>5O)aOK㮾cMU|F x!n("  \b~P 1^pdB#~kq3b}pB;Z01s7oWk=׻A]br%!UER hF**k=Az,pݒm]pcs`:aY(*q-Fj}ܨ9jZyyu bƙX(Ym a:7@Rsi&xf?ÈF (Dj8b+)"rHЉ>! GP,zpi .; }&m: D' L^vBd%ـH͆Qfz6Ogll6k^;8W볚YdW 5X#n;pن*x~'(v)cYfRW唌IVO%fqrc@^N``6t?EUKᰜΔAo?I;4 nI(U$ cpR#Ք AlrM^7%yNxlVN%ԲPSm GjWhw"YΊ9sQIv)4%`p<=p{ѭ|hCCo4;8zF0s1줔A{BcDHgAņ) /:7g `iZI$8 Ps<O29qwE;lt9SD i)ג: h@\w쵿aҖtktq\Yc>9k N+GUF\JoZgP;i^li.%{6Z^wCqA0m;t+waĴz3H32hXn&,AMgR4;ujEp 3F|18 ;6 2W V4{ J{ msH+YMy ^$IC5K Ղ)2c_R2`]$lTu}RKI vZ,fQoBdbaC%ԕh$5UXi9}4/42u03 K%3MS88u f-{T+,8QTŘO"תDB͵P%"k(B+Xv3*x$7+=w:\ܡSu:0y+Rc- 9L2KIj'kѪ[QsX[z*[Exp8n$C>Of1Zb5qNFakq10sIi$X wU^$cg5fä*8+ N% @ݱ y3Ӄ8u%Ni%`z6sUzapo!]uWfO! 'VaͲy"8fyN`7:}^'Ua\52HHiQ#NRiiV%e ᙊ 5>ݚ7e7<;ٗ)Fpۇh%qL)HkqDq=EHW`!&.s{ Tǿ? LKo` gե#T =UH#a 0|qB>8a6ƽW;+Y7w[{͢}XU8^N"=N-9`SrNp&aenx,/ R\nRܕw p=Vˇ /ϼI$κ:3=|\Rimu#sF+XNRӰ>WovP I$D Y_ Y#igY^..S3ʽ8 pX4Oi]#Ȑ2:me_2֧S4Oj&q"-a!=cs]qXv l\^N6s\0F >f: x{ n *R&W!AΝ^"Ky怺~$KsEIT`= _.`퓮pن 0LN$IV{Oe28, 2w ;]p.]Đ;m:؎vI$tw!Wx8ً8\)`i=6 5}?֭h%ϐ9$I,!T7j ̏r\A`ln\I$ !R("vXHs oO0th ,6j'$.K {[w^ '_cɓʶs^`!9f :\ F*:jL0!P sogZhՒnW-73L%NXF !XFK_Qgk^\艭|NyݒƯ6!7sFy#Ex9NxZ#mtD J]9#ȅF'A`ZGb5?\pVz? L<3#W#+n]&`BoF/ul=8pDV&.4k\wUV!qsnJn6K裛+S t`Fl2IK9 zJR$˭]1rֻ<[`2FܲqpD;3z%z'0w*^*ap٫ O1\k@ de0v+CO̐HoAa#Ei;*'tUL jJYX`sYHOpV_tI$,ak30 &Z.҄:鐸k<w! @ ik@e6< ôbbgIQ2:ש r0;GJ`d+^}vLݭ˰d:#Tqkqc01\IMNJ1wZ)KstND㟄Ff GU5kx6Yt#wy%*|98ih=1hK7^(=s6|&. $OcB`4t\4uDn3D.ĦVx/sv\)p4JQn# v0jHKvA8 NEvxd9)Æ:wy8fc%LJ18N BDy&$n踃B~+lxkoEA8D%,>?`9'sMzIBI$KB"z8e`J=[ pCr<<;Y'Iu)Uz,aTˎE:`$}s$RDz2 *n8OQN\]ON)F˝=E( '4ec'ӼS.>< Y蠟/8nqffeY)Rĵ弅< m Uvr3); n@! Ja;$#h0 OVwA<;Y*ABz:D@5s[ V1*xn&!Bz nf}Ce!66-k]bUw\0QBN1"u[>vKF/(v*Xwpp*q>ipWuHFsUB+p=9hX xl4lR؜;v*qz<&FgzIrs`G".& >+0I$Hl53s 1tf[Hװt 'GT%vp"=^FNГEnL!n#\O%l8fjLʜ=e(_MTI6LCg&2>`w({qd{Q!&2q#>V? \8w;g$ˡbRL,$+pu& Fa++>@09+3ט؀PbƪZq]OHuߕF=dI$,=@ BAht9*˗ ;􂜶.q;D%)$ %M4"sff#{ d̩dgG٪Y$VUIܦ" sW%,ڊY, [9ww46\ @!%Q\gaIBK(BB56LFc䅁)H9"D Kyڴ63 |K! `*4{c *u rnNrB'΀4˒Xw~- Z+ԥ"ZPD!UCHy7k [s n9nd!H,jj(BcI؅EƝN K'0r**MFbpX(BZ*H* l~]Tɒ.@'~J\:tĀ*$[M9m4U8XY.fhs'm!QtVuQe>/#0}dPf$יyt5ި\ tR 6&Tr!Ks0fyq }4P3e40 r)ݶג H;]q픔* ?4쥼E0z7}qAy1pfJ:Mc^e%>/Ds4凑d!YÜw=D³v\ 41KgcyUQ{ä!Uqsܫ,I:fRM2'ֻh s!I05-N'2\FkHC]'s+N:TEl,{Q̢DYY]gsba4lCkDŵ3y&}rXxC_? #35.8\@Qީڗ{DE*|,OW@4dgpوkAV=Nm' Mbp|C[fH\/qpMNW.'e[7ks g:Hsp NVq\&x@>\I:61Qpap5fF)W>?Z~Q1XXe o+q]JJPUGSLg,ny 0B iYs:+s~.$,ϑaVI:=֕\ʰ0A&ΐ; <<^% Bj;.UGih >0*wXi$pJa{=СBCZ}}S p qT[G`Lv+)BO@ٟ)W 6USP~,W1]a /UAR dʾJ endstream endobj 1861 0 obj <>stream Adobed     '$''''$25552;;;;;;;;;;   %%#(((((#,0000,7;;;7;;;;;;;;;;   %%#(((((#,0000,7;;;7;;;;;;;;;;   %%#(((((#,0000,7;;;7;;;;;;;;;;%""   o!1AQ"aq234Bs#SrDRbt$c %&'()*56789:CEFGHIJTUVWXYZdefghijuvwxyz s!1AQa2q"r3Bs#5RCb$Sc %&'()*46789:DEFGHIJTUVWXYZdefghijtuvwxyz?gtiʠ?[ * or|}^/Wߌ/eNu?ҝ*tP;NST7I$jjlDH;㩮:*% ABJRM0q @Q$Eo>R> Ϩǵysjl e6m}6LDҮ+1< *Kk#yثf~%ㆆʔec얘[o!29NWQV{+͚wjҘZj-كvv|7ypkX-C;g7:2*G*LG^"VWhf6KxO Pp3)sXK^n^7K;\6p e:/>..'r=Adtְgd"QnD]m[O;xY^EMT/rq ȩI)] 69bֶj}P߄[ 4%гU{A$K_3֭3/xnXjA-bYh`I)0b]6sS*t9N8]t::6aidnAHp3) Ym(B]QpS;HhC> qQ v!, +wնm̓U-V۴%}rG?Q`䩇?x62m'E[JUU <骤p2ʃT y e*Q*!Εp jP{a#FaC^+]hnH7v̐߷7G{°2 UcycŋM#OjNC)M䭻ǴTNTY'RvaP[j7Ԯg(h.h^Vfvk߾"xp9!#%D1LqbAmǣ:v.a8AH&̓vQPk kV3{Mɾ6zKw݁UF rb)waFDgU@|Ng! 4K0V6}q Wq'LsnomvZl#Ɠ~kD6nֈh? d!z3SU)E:q\;V\=H%td1#|#V6܎DF&4e.GZڒ)-sT2%E^ϫw{O+{>˳S~xnd+Ҹ2ZnJ ) J6]x?1#;+٨lHUt80D"PZK)K LM8d}4$R:W9ΰst!Qum$@N l*gFI}v;ݔl-H3.(O4䐸:gDP6Vyuhl5 >R\k#dI0xQ)Rmi6Pa^NLיԘʎ/uڅXq  md UzˌUu`n7ڃ\wto,piW5)jX]1r}y! .㏅uzM~^]:'imȊrc1<|{Uu;zF50VR6t)r^HwdUozD! I$!BI$!I$B!$IBI$!BI$!I$B!$IBI$!BI$!I$B!$IBuʅ 5ٍ9`կ{%rok휗L jϏSKOaPI$i{F$m[C6Z/ PF֞AQHXW}ʆ23ņɺuǬ=2i)U,K}lЪ06w*܁cCQUmSɡԃI.Ӑ#.9SenLGb@q Nn¬p2"c\de C"%Snx2~нvAۀS$<;bJNm DorI\];5cj4lnDFԙ<eeHRu!;JSacnd Zф %ٓ*2H#|v#Y# ,4! <> D;. .՛@!FC\/%j:atbTc vVXH6+dRaadlf9 5I"P\;d0^im -SGN,<ӜDn]I&F1=;&uCKr̝Gxׯ,! 3R;MJu|,ԙ<> 2oΧiJj[ajزnNKS d=aKN$^MZNv m8/|7U55qj%BʸDpRSn0ʈI bKȈDjYk+ WA<.F@#psA dP$pս Vv*{F L^'-RekiXɱBFVZfȲ 1қ5l| )mr|mK1Yd;mkʽ[@x kJ$1HJUC\bR716N67ss`5UjXO1 5",N3MSp5o2pz\ < ެ_kݧ6a L&<Gv;zxi{7o?jR\ƹTmVTm]Ibᮠx-9M Uv( KV V˟\9+~[ys%xOJ eW,h,Mkca9e}9j6u= ۉ "弫i+֋3VQP| +;oa`y_? =Mc9E !^bm7L|¹Rar.ܣ(ūW瀫G;X.JzseoRQ!z 0RgJMc@+*cl9/;ܬÅv*&v'B]Q{ۓء=EOm1 neUvRPe <! Z-$`[33:@!ez5 U:Uk9c*t9$t\e76FasN=b.yNmvT5 -..OXxo '.Ms9e(M\osF7Qqp^P;6 s>\M/yk q'"x181a ꆥlJKnNAJiE5a912(Ha1eXpw U]jmynߊVͲ9ǰ{ J RZNG22س&(|+0*Q-o8\X%)j7Ok`oi Nb@S;.%A: SZf[ae1E*a.VCjA{Aq1i9 J)Xn՞1P ݈=MLl)6dvݶ9'7 z(Hw5x: ߴUKD^yCcH[kHYP#ɱhv9@ljTY/;ccKwsm⽚TĕS69S9 вSޱ0c?sKn,:^&EIX\q,M-kD6B+<7r|]ژP8S [VT,@lsKdysggPDdE('Qh9RĔ ut!Ggk P\>&SNtty-zs@nTcq-+dj.6" OnCwܶ=>. r̰ B9;^ߩ82,zƭFd^0iЬ*IwEu9iq>7K/N]x5*QLcͶ$Q6q%QQ`ACj^Z@Wɻ^Χ3Æ֤˚?zl*f64}Me:Gt Mqc6*+tmnXTi=p%;z\=z{U&Vu4)ER%e#cǣN4=kzI$LSBI$!BI$!I$B!$IBI$!BI$!I$B!$IBI$!BI$!@Zkti9ig`f^[|#|Lηխ 7 kG1!l\/;?튷ߔ҂>AfVuE1_Iٜ:vZ$/2{UPĦjRγu([GE [&Q~$OM,:!LR9LM!-u^`ܤD5!SڶAkx,a5VFa+[N.iŦ#>뜶-4ѻ93f #1\[9X 8D X ࢭ-ˌa/#64|ýz!&բM6.@0"ꬒ9a=܆rx1X_P1e+w$b[jDŽ4Zȶde{m$Ed/n7s@>-MOu"ƽ6&{ܗi\xhbOsl#qUwYE2I&@H-n-rī}L 0^HL <{l-pkn ث0]{q7׹0ko4{:MjǬ<oHeW6Rs_Hc+g/v-ƚ{M&Ԧ0p0>Up. knԥWsiwTF`Pa~ݧ6a 6=͸!I ^w$9Sf@ܨ2nnjAqI$! $HB$I!BI$!BI$! $t!B$HB$I!BI$!BI$!O Y^5y;kmңXޘ֠ZjBV_^voo)jeF卭OaA7\ Td٦l 13=j٨ۂټ[(Ǩ"Ť6%s=X,8کQMȇ4Æ9!)XPH@9' nLPe^}448h|HֵZ aSMmb [)i l2%MIyiR.,uG ݼ#17WJy߇Fr&Crk[~M: H6-UUhSfwD$'Ĵ@:wp+iEGhMUM$V.|*ӵ&{!ÝVY Cg^!\YѦȔݞ`KSȑۥd9SW9cU2HC\b4\-0^6ABG9pB=rKEWKƆ97L'Цʕ7^ y؝V͖%2fOmBP5sAM@FBɼyU^~uv+p` ]7M7Dt\(<-hn.$GHw8yeYMLY^m[3hޞۛD%2Xks`j˚h}oSy?fݯX@Ē3HV͑=z/IR`xlKoY)䝒Dd:HVUTp !׾c? VH0Wȼ])|dGj-j&fbKi'>Ve6nUjcO%oF@ݻol(-sd'0p5 0e^amN`#`R51v')^:(2#bv]7Yn23V@ Yqy$%Z/ԫs2B67<MX*/.ӬI*Di'W"4ԅR>°斸lӪm=Jꁳ8IW1O3n;xxҀ5ߝ ̭P_:Uܦ*?IU!Svt na`{,D7ݒք/Gf7 X߂mG3R&s@zN^9.==O-/ i-GK2]n)l܇Gk) 4)]U;xAx¦wTߨ@Å[#l (T0*?@P|tn U{!QD6Uh72OhfDI7-_ Za3;jXY#$cʤ6:\':^raʕQq\7NҠAn#^~˶yPgZJzV\ڕ ]OеEvMσ:Ed@bѱYuAL$,>KKqqsY5Y VMv@.ꮳ5'ъO|,HW,pǎ*׈hZl&xJpϬ|ŎI'e&~N hd@].#KA6+wRpR[OllX$oά\)6Xq p.>UL\w(qrx+kIwQra%z#Y$.O*m*Ì٠ݶ>gu­afF8 Qu h^LVuCp& ɘ]Y`{-@GKǮ{-`7 s`3sݝB9p~**oqp3$p -v30x.qTqcut+`ZGP c1t nE-QK4c  &LؘN٫3vz)0}&n89.\+56tL+k5} (>$^7hfp#m3W),TJ.nFJM2H?Zcpp&%6kdSeEq cڔ`oCZu3$Ea"З!cA6<,g% O{݈`ߩYVyӧY|=YR;͜UkXb~^IT 42#pd ևpuLـuZ[wBk}-skuQq 8߱Y$^Ɇ`R4JGև&H^BIg/5V4[D4c@#xk"psIh"&,nY/c+f@ prAد$rSָspǩN οzW\.֖Z#U\-xû,aqwcy},7f5SMیxNcCyTwNX[gW~mN٢Zc#yVȸ몷\u8} E]?y^-l)T1PI'&/MBI$! $HB$I!BI$!BI$! $HB$I!BI$!B(=E"Js:B_t9UJ~+-ՎU۩eRq Y^Ɨ ,c27 rr4TjhQcȈRR QJg@ N[s~Ea[az,mi@:2F{ -P'gHu!h͵3 uz#r iݤI;kyy3cؚBYOzrZY%lxJj nǞԝRF 08#ht:>ƿtKF"%^vaȥNSlV1A!AsXb QZ\ɬ;Z\_;xj=m[J^č_nA;כR T<.josm?JٓE[ ]ܡ upoK1TBxv4ba"@@uZoe`K;͹K\ct^%5>R]ƣCF ϕlM{όI)5 BhV%&xhΰrVɐFPNMn7.[fX܂')Z Z;3] idNs1{kB(TeJRHă0W'!um[TucH,.d©DCՖN71Ri tt9:W gc[3Q{rN dz{jdKȩjlYre|<iSajMfTH! Jcނ-:񯱹!:WAp[i()bby_&=YT4aC nƁaĞ%gm}Xuۣ`='j[z82N&#)FJB5W>n5ujFY7I Q<ᣂ6Fْ#";YtCƴ0<&+0q|;J[MGr߼WW[=3:Z 7 !ˁns{KG^$}*vzma;H_U H0ъ} q6qr^'YD4SNOg(4/@]-DfߎP{_z;EgQe0shLch?:sy:֍-g?T^6fX?Ѵj.#k,cÓ\u6β)` / ]U3GVCfz9ى aRZЪGc>c`h NjSGaeEָ|q;bd2Neb"e1րt(551v2+ ӭC^.˻F2]Ux, dήd8[rnN4| 8v;&*y!dVE휚ە[<ֳqSe^TzV˲2U兖fI4pk'jof^ʊ ^ma\n^cy+H"\|nt:4D5Ȭ`IY#  tvDnQI +^}Х27̽;ϳtYBI$! $HB$I!Bsg41o#idi4JcABuFQԛ*ޭ!f.hU6͙IHR1ө%dpNccVpTC#t* Uv,P 0s I$$I!BI$!BI$! $HB$I!BI$!BF>ӟGz Bl8]!AKJ>[|cB싎rw~ӯV9L;ੴه,@+@m j@MVieMЯ98Nr`}Pe@Dr;! t3zS *Mq Lu`I& $Yaarn "uJwzBelYep0Xx`;0X*,q!rQrel*9z/i^*+¦ֹ6&uz{i1r*t Ĕ> ^.A:CȔYn_V| mͶ>M bm烜cuywv j|Z hVz^>d5k-)7Isf0Am_ӇDY<ޔ<7pa8ē޽J,q `i)5v6Zֈ ˎ8;ϑDõk %Xf){o$"Э..Eht^8.'<!GITǡt{0k+lrW8*70Aa?4_ū0uM5}VTaɺ7%ضԽ&;*SmolCt.8F:`*IWShVJ.SP'mrbvT m1Cve6n7Tg8"`yon{>c:oX6 lt %7̮mQ٘{$=][嚣kڋ\K(oFNy^wzJ-Qo9]wŕqfH׋8HpI1PA/RMۯ$4nӸ~xio][Kڨ4CRrʻ(nբ8x 7+Q坑Msg^pTIɋBI$!BI$! $HB$I!BI$!B36DXp7kZ#<`iCζKtkҢ}ٿTj 5ik`ڛSmZu*t2(SeN@k_ai&E"͊%*cv5:5&u_tN}6CKuMcTF IYI7ܵ5_iOljUNC@c!n8\ E3kl+\CrڳMr04#J'cjHK˯Cch!tWak$hXWC^V1n9! {VD8ss2*l9:R曔6|l,P*5gT#˛ohRaִ7Y˶_mV,#htbj6 ƼZkpH ̯]m3o^Nl}HX&Kk45AH\ߊ@ThUU۳ͥw}DC$?m8ɢ$NL^I$!BI$'!!Em1dI-pəped3w4] my?d%<$ypT*r+mWgEcJSّaj3-<#I*$B⼭6}axl^7ݭ] J-`cs.=d4:H %FX"l-3y(`0Y\!y_+cfhӀhGYK6%؀ߪV 6T2[Mԝ3-Cyu2SaXƗ-P^&Ѡw`ދ|2Cw (T05\ jߨHco@Ӄ2YI'Ph+M-=;"cwvɗZe2QN[HZh Y$Ti6V9u^VO5["UvL;U3Zplw*56 Cg =B1ԶBX1z'R49Y "个b ԫ˛m*|ցoܨ{nkh{I+t {>襸7$R#5╁ckkDqz,1Fow5SN4,q/Ԫ_5ǻ!{V[8{T IZpZwUkY8kB{Yq\+tsU|8mdnkb,KHV I#=dh9p; rBvW ,9l0ȼi/kdkLauahk8uxAfhȡ ve]D6LO1UCK'AlqR<&ʇ4"-M! u;e ^l+ѧUZK ^Cé=N0XZ8;jva? wb1kMl'w7j1ٷ)svAnZt ±_ux%9#tٓNF7G0KHv&!=C59 14w Hi'Ukj:S;=}y5iv m*Dҩa{eCq 2'^ڳb6]~v E׫R`Yg:O[: t&s,D< h֤IsZzgLQ{q<둆.%6i5d5 PiVz| Tc*'qU]|ZضAlA{ܔFʹ%׹j'hx_@U#aQL>;F^T_A.:̕8B2 >}@.1?0lS A.z%r*J'zzg 08=K'?Y, ō9 Ob )u4m)b ɠ/֯j&Чl/TK/"7 *ҲX!hlָkijw f7cax Al1j )lqid-'6?*Iiu:/;6;E*S=3+^_,Sia n8qab#voPn),NtTsԷ-iY04r2IXvMSTB^6d{ yb.|kN.ꎜ[ٶ:;#dž%MPQ6"5<χRkhkOH1 -{!:-mf4p}Ky]ȻNꟊ^?caw_ZϗH^UpuSZBKm}FGwc^FYBNT' "vL)aUNa: &u:"Mހ̤ qN0l,fBU]^wb?fӔRyÂ@S:@C HzED ά*ot&ٝq%z I zQ0'yvs'In\&H'sTbuW6B$؝/tInF8/R(Sf'k֍.\LtVXqv(Ha uh{+&1j.Gy;7t^ӷU]2]`rMu qk֫c 06rdVȞ.󟰻YoZ+n@%͛|%Ti`4aMPp#n#-F2WhKD Y3^](R;&v}1?#Z&ϱ +3V&j0漓Ap(bJt`9.ӼETLO*RmWb mF[PbߘA$IIeBI$!I$B!$B!K1wFKdQ옻zTytw?>1UGy?[v5_WmvBygnfJͮ4(V:Ȱ/jiNL+AF]J ZJ LfV93JZ nӘZ#qN} m %U-y|Ѩ1=aZCYd뾰zxxJWN#g&ցl*sCPGF qxw]I$ -ā[i9Rx!lK`AL4"{ >u趡heUXGrl9,18s HM΄*\4I"UA^L<0*Z&K QZp(kG r iDgixb\wFSs4S} ʔRcØ ;MX=-~ )w[_*Tiaoc+{*>pų='Yφ-~&t&ue>%.<@E,Mx=,-p2yn˒5\bM=Ul8MLфXV*y6`TcĕJމ1)i5 [ͤ,iJfBƀ`+#.TyN#k8a`oIR7g#Lxu6흍t :i0 "A)Oc|!e[mP5-kH";ףJښ)P`-pq=vZ|!9"@'l`,靔 ,fzkVM18ܞy~Whk.ݝcN>+̪bXe*6m*U6ĺp|jaͮxөxޢϞgVLs+S\IQIn1sI|~[Og}@7"ť"t2OB6&Sٶn6Z 2UyOjrmg41ؒ\- FCwT#!4pM+I[T8CP6=)W!  ^&5MazB`ɻW*l{KVkc dɻ=F`8.M C`^I&Jۣ7ln۪Ìq\us-<ʧ:+(Tf %7xc\ (}UOfA6. v6m߈-^UpxǼ7 A^<.^KxݜcT_E9qBS#{(69j, {L n):`&DIcMœ m/dB@2#x۩TqVCI 5eGb9@LCSlBuZw\AhG.+m,3$8Q8Siݑ{*w{N6YfF:SD+m9X5-qk6(*|d ]mHܫQC\VѰX8ɹ2RO]o>U3>:^oh >qVV2#/"6ԦC5 \mUiڠA[NVCy'mp4@{Btv\zЄI91tT! $HB$I!BI'B!DDn$ eGΫ* wUooeIUy#l{by/Uz ScpkP6ct[<\dZ um90ii3k{t-kBa$D+,4i6=jOp-:,mVIbs\A#\X zx͸:d!zZkc9O|&l[>i qNW:J0Vl$;,SFjb~t`HP! hkw&6}xsqӚBt|ضad-al\j]nzUss4'e2sgljW27,i˱ k]\-wRuSRi=,Nxsե!5#Ut ktY8mED, mr#$󺤽!m۞i\BUtk m:/xA1ڱ0:\q]'чQ.229HëD97,:PTskXE#!9® <~H8bs"Aj;y/!mx s^0Ȱ>5_j6U8^ZYvKLVB0[llt6* k"8x6[4c]X7sڪҟlWZcO^0Epel1/7Jͷ o #.nQCG]akSw<#v9m$kD ۜr8']r:CoڶaJ߱oRk ;s^OG(Li&ق@4_T('hd !xحq'6<]N.uM] XALԪo8vI2ny1KQ#@8b2AG}+h=di̘|ØEg6i+wM/crԨYbpBm~iڗg3gX)mwR jV$jof檶x#r rͼRqFZ_a̡b2)PәMJY/HUmXsGH,T֓6#<1x7YvVTI_zcgv {9xd'ίS؜Pi<ؑk5f6ŶgkVY^>A`ڶ*ђOڶzx4%8e&a<]Al:hslF҅[XC|>*5׊A⛁F{Λm4c}Ţ-:8<ٵ_TńE8 b}|+A_ >@qu8ъbNMڪ?OyU&8mZ5xoPI at@ۧm[KOgh˭[GzCNq^U:5v}`6!5? 586s 5YPLJ=<&\/6v]Tij%1f}T*SlLdxhr:heF;OvբGkSIlyULKr^>ձ7ewfe9-p&F4Ə{O \߫@A)|D9pÁaef6ǀZdp i'2W1E'׺I'LSB$!G]ܤVޤse]wrҕ[zY|V|Y){~FL8e[g&JtI51B8ܷidk;rF,sl+v(|#iUA^bABCC35n-qZ/,*Fc1XyN-sp.jSum-p{Q=!c&\4Eвv\/](u#odnm.jNZVEqcȠ2d*(E7qbё;lE f3[)ZODz%c Ŝs˥a!B4 )+Fun"- $3&ЏxCazI+z46SgLG=!'< ߸g$ݧp ~urZL:cV>*Z]NTsɎ<*M+uwF AѼ #ܗ!9<ݢ0*6s G,2T8_"zA'xͻٰ tw5ߑl,FTq!W7V ;b1qUZ3+O\ؑOwM+];Lc UUe7f5P۸bڲI̜ X' IcX* I pV{>@&B]*.sm Vh pyT)k9M: \Jv)Ssw"(@GIj\ ҳTCԦG^nUxVu ̨*;hkC\pev{M6 % +[{7[: ^A.voeY# =(`|ܝ\+15,MP3G2sF!'ζc^ s"d*٫Rqc鹮i Jmmh:I[ϩL0/(g抍И^ Mt20pG3)E7M$%$u;8iLsl:D v9$%`MM©l\s[\pkvn}j8s1 d *x) p *${fۘ! K6* cCҜUy{=X&<̍尋rsݘ l[̥,s9_kߑm, mʢӼ$F39Bm [dK44b\N)n`pTvf̀UB`} iIZ㩹>)J#t$ٷ΂`,aNvB8@@!7%2 "Ih&}*96| {M ϼ4< 7AcZ >Ыsg@씛֬Lźi{h=gp\b''I_1'I4GLx>5T| NQDZu 6(ӧIs#uLRC 7* TLÛT3!ݿB(0tf%YieH6N^: " wH HxeYM2mFQi` «Z{ nNini4!zFi_)Eʦ33Xw<fBw.t!e @U5\Rn:7I rPJjS"+(! KPCwZݺ\\pz "437 t <9,L8\5!yչ&u6`=`nI]-ZqUsLk0 00:S'କ3vƁ`քc_#BhV69/kvz{s6 {_#I x% #0Vhp{bpiRj"4Y[ 8)r5:IRRycub&N>X٩V47x+r{Hy,m;|0YOlO4iRh [XD4ѕ0iq=ѺkU= ImKKևI& "[t&fk;==hBX5L.Цl|6A{fz.b G+rX]V `Ÿ[UM}Uc#=e[+RhANui!,TN86qUOsS 7rTkT`4\}tQx 6 5|;E};y[ .ѽ{#wA}:>\@bjSڶv=1<\JژM)i:M2!pWqB'(͢a5G$I),BK* UAN,(JmVgMc̽dץ4ݮ =6i$IBN;X!Z.좝VhjYH'iٵRu'\<"0_VŦ>f1sAiu!Esv;B6FKin,p|TY[f} 1 " n~T5YV *fqS*0yt6fTVK- CMa 9h>7iSZ}C*(#%;g*;Mfc&!-6̊[HL:9s*xi4d{_CM>d8rw^Cvu*v[+TpdUb铁>H^õR3} 7#EY ^(A#| SOY'YU8e 1sZZ` ԬleQTLЃ9U-p7{׸|(2\$Wv+YsiY~l=|T-{˞GPw|':AfC֋<WR~ϳ5Uizqʤl͊6!b B6j2R)X#\#=g %m:iL`)Tf` G/)Bc-'@jl\Ł `{Zq'8 Jlp5j8Nc̤SboܳHu.د2呏-=Tca{foaCB{b4)km^ 7luw>^u1N<[nY6FSbN7^٭`Ӑ gR"07wMIgm/ k+ .w0K1qf_h{V8d}P}Jj[ QG,.GZKK^5VJʢхdIU.V% ضjwwF-k#I!.vNn.+l<.ͻ24rVH dR5Y-ggE[I+b^v@k0Hj.a\(ߩReju3>Ǹ"s^yiqY;̕i;X)7S{uVM-˙_*[K sD6ח_gm9sZgh odW7kو34𕡏anֈCKE,,Y% h-9jjWͻzjsKBpqR][%geGՠ_hNI cmv>I Ø4Feճ: @k\AqچI1&P8gq#>%nT]m׋[2zҶN孚EkSS49L|9-3G_p#puoZNm6dby(BeMҘjs;*)4O6d8D*;+eA#y `E)eV5Cdp rjl;fI'0ɻKQQqkt9q@I$P M}KTv%A~*i}^->ZI}|K?o >g)rMz25$I51BI$!Zσ'>-a(P%"QH٣2vt,{%H|NZ|VjpAЮsu9?iu`Á[*LO .f?_!AC;=2zX^.BA{qpTU:AGeK(ů!pڹ#spsHwѶSN Bᬨ MvmDn7Xn|b'kuLMJE} (SRp{LlÖ:wFv4nmORE!CcⰈtFV^ڤn㰅%ڶvKzO0p^~X vJsTkFnpsڸ,ӱΑ6Lm1'[v*±#^EU-RIiq Հ.(Kڈl*Iߙ ҡ&hBCrbIbOtnC*7"FJcg. V6n-sAӎ)ŀ< 98jUZʅo=h~!܎*Ӻ懴IgI7x >vZP-i5xZ^ F` ewSsQNJLpvZlW׉Ke q&@FE F`5FZ}VkJM7Vf`s's̔!͇6aYM߬+f %Q["ciiH8$mSj6ws7GOe ^D+|eXdW9JkoK晐G^cϕm *G}N_7Ҩnww3_ν!6ힵY1W詎 v O'9"y !22 =Ā/ JM VzK꼽76E|"/ =s"0[V쭨" Bv s۵Dnn$_V唴R5haԦIu*f8 5 n踹S L;spV5Όl#h);uzpCs^jnҟh.cܙ8n4EպuG4nF#Q ۴S;tȃU jcMy*[~l? YT,eF{-'?iQ7:3%)#|Nlsv8sƸ8 0C"A xZjaŮ+# Ldk$p u*܇7r#hBpGR4#wxW;+kit?D,7 H/2#jelV9б▐!EgH+m4y-`6"jW,yG '5$I91BI$!I[O)쏽U$!y| g.D6!eZ-mcfj.5ErڠA$p^s = C|00k+\I884xrrV#k!LXC|t"AvAj+;L.&Ku -.w6cnjuжԶ)q6!g,:J4BYXu,MG> M݈iM4É--6%ު"ڏ/:H;ゃZ^`)v6-{I#\CS2Iv{b, +{[|'m UKaabuzbD9g4@;,btDC3(] +bq,"4*{4C`JiZH qY>; yu! J5Mn=I;[Pe0F*"1)յ&Fƕ.Pt^ X6r1:{K,m 7u)5< F@v8gԇ *A' >ԡ m\7DIt (88= *w'a`NnEꮨawe3y&B aڼ2^ sHPrGAi{Iڛv?u/f`s\TZPpk 'qVm,JVMNL^dZij\$q[Rű:=*u$IVM1W2WKX)P>"C^axvwlH6Wl˚ĕuKqb}G5{'5( i 8ޛ|)x;C4$=@q+5KĚ6(Bn5VK19u s EIkRd3pH;P H"[FݥHn^bSZ,rqoR ,6.Q" W+ldd)<9#!^IaHĭ\:'NY14Z'Xr;NZ,ExBگ>jU>:#LDŽۋi&n xg Z`b gaX׃nHmۆ"*fN&āxULg=A[3&zךA3%Kj8,&@ṵJvpےi/ )p3x懈?7d2zrɡfM l1Uic*, jwwgCJv :P_>`9͟WƫJ)}{l5~jI$! $HB$I!B%"y 3rr:7bj Jl19A>nM'V"یX]Vv:[uJ EmϐD5`X\fA-A9xSi؝թBXȎ '1Dn3Ԟ]ȋgv0rsr7@i{],$BtAz]/=S^9pC#[!lqt^MX+AȐ:d nU`C7ЍU<'7psvyJG*A'WNc! :a8(QkX uqkqlr!Ap<78RTiQVϲ:fʴ**%aRibUSsX`Ͱ>F^رVJXZ@8SmuECn gU_5ddqꬂ3Ra!! ;5Hʨ^*w7 ;SCHe*gLHJjIa{ ŒIȫX63B(YعZY. CQV}B$3csHp  R`$xU͝@ vuOmMIj+ʯuU/sK 6La3Qñ OԎH(դI 5Qܒɮwf[]0ef %r[RpVP,m6t!I\n*E6vA:К928qL1L*dTJntnnaAPzXsCH"X A),*5鹯898q+\::Qa&ǜo=tgU85I$qݹÔ*ѿ B]7mH蓛~qA;|Q>I癋ɹ<9^yvO.mZ^ ;uiWmޑ*JY. u]51zcrAsYp/U[0DRUMԨ5g9+82,N*i IB_hƒ*mToD-.sQz!79)ZvZy(Oe n Ij8JVkLIF6}RlOBdi0Ea; 8嬡 *=N *GT*(9`E7h<ߌ9F^vZ!6a*MӹV*Ɛ TӦ]%݁Vܳ[)"jJn]BT-WҦzfʫSbZ;<J٤i~';3 &hڨtGSgPpW݀nK:/Ce͢n'"mgұ=7ۭt {KM$H AII~7F(೤B6aUgk@cD_l&lnнd j"m3pؑwgU ZቻAYy߼@3UC Jn`*#hdmJ68nnk2vr! k>'ZZGUT8hNcWXZ6f"o' uoY ` =+k&Ga6Lw1 qa֔*KHBI!t Uq86Ӈ'j0WwTIN/!URj^* d7T㵳;YF2@'!yhq @Rn"cm׺Zc#7IvJn^"3xJnYؐ:Ҿ¢(B@g{pHKs0D 69*٦V,}3,'9i*2Go>1:_7qw.ܜHBYPÿ68ƪ8K4|! 0ۊs*.6wEEl1`HTZZ2b&^w)m-q`Ğ !P5k Uԩ¡9Bvʮ,9cV2fW7h; mة:T*3|cZt#BWw Z0Qj8f) .v&sW_{.'.؃kmzqWxf\oTDù߾.!Æ1B,G0~"wK~r7x*c\&C2r9S~E{tL7X˕[ZN#̲oқ_55%YmB>JZD}InΤ( e`!{#sp Wf[z#`?]Bٳq#%eέM\6g!JԨIcm="pl0ڶ&V1ّoEguP_^-hȪMgY!w"o'5msq8/~j$J$!W-DM|/Y2s5*г O4:dl\E73w9#ca7Z_YC{eE$,cf2d;h|ޣ8ų7=I$!I$B!$IBš twIOjm5 CKF5OG1 Rޙ$!C#Ȏj؏"ܥs2HB_5OGg#Ȧ)\LSG5OGMSܥs2HB5OG?E<+! ?DsTyT58q4S* ! Mfei%lezWPGxJ&˘{A~{!$6n-XT#p P*o̹^vnz np]r.TkjmVR`Bgmaͻ~T1GXބ/KEJDg%`k]o qxp{ !YX^7Bz4Mu-ñ6# 8' ~]L*QS!A +c;BزAA+!5L:燪'AB%=-0Re@䚿c/;I 8I\B+1"@<DQ/.zU%@U,VLp*ܯ4wBV @ {I{83n"<{*sꀌi `IEEZΘiu6b g:ǥ>Al h@MԬd/Jl..GҠpR6:l7\$N!Vn1'CHO=YL! u+L)`,%bOf`L@)7=X7k&W&^]uXJ7P>rw|>P7}>~uo0e6 @`Kkp2^NO&m  >ؚ=YȪI$!$IBI$!BI$!I$B!$IBI$!BWҸަ" WҸބ!)$7B I%q+B(I\oJz" WҸބ!)$7B KCE; g]oJz]4A .i8ި3hU3i^KM &' Fk]oaA>3l!RCeske:>߱;X} (FDGj#6V;sh.j}va8$ql{67ȟ(l)2Kj0=U58PcJ,F5F,e7k(ӈx fVH=uGz(GL:-;΁bQ!i#;go웇hRM'vC\^Kkh<'y;e!LluW&9D,hS* ݉=:]hMk5B!AY|GaVM0ʂiea[d! ATE>.++(sI7*G7mpR[w7On qLq#-I!nBʋpx 5od}mn6J=;Y$=PI&4 \!eyȼ+m֌ƥl,ci550RBt\%p!Bu&=ѼHmuCȡpH"@ pP.S g4ӑ+%cZuZy()#xO=هUǑpj !.-<ی%ߜgA둁|5UGL `x6dWrRѳhI6p=Ͷ!6s\i$Ҹޚ!Nk!Nk BCA. 6 V6Rn60z)3wF,;(ק0ӾFLR,;J_::4O/6-ltXךtj6C<ڎݘ}Oc)y Jq4C EHTf&3؝rU#7ԱY436zDv72|^ű};"*RN4ux>ϰl YOmY7=Xa>(GwR\%3rl%; U9 I\#)(;Gv~lo ShYS^䇠<§q{/$=>߫D#|Qܱg,A}ʟWB$=>ߩy!0^^y bGkF'@jOPݍ-Ks[@xU (XOT Ⱦ?eO vJZ:M9}`Rg cANڤ ^s$;yx/@CaS8 q⡎a}R|3 @+FI AXOT Ⱦ?eO w%GyGihϜ\% <3oin6p]k;y!0^K@yOۛn. }s3敞x;'+EXOT Ⱦ?eO zu^VegTr($;gݺ;'i@=gwHz*}RCaS8S2VBo#G=Lc:G[H~E,~'*G_r}R͢.RmJe݀Nަõ0dE6Lq+<T/~䇠<§q{y$=Kj4V.zٷ}|E,~'*G_r}? +}՛E9͞CKS)4׺az qԼT/~;0 *8]0A*bA\/c>YS?"?ŕ?.Rت49M'5QVZg@yO^Hz*}WR__r}~E,~'*]] T/~䇠<§q{yHG_r}~E,~'*]] 4Td^K@yOE)W'VKT+G^rmZ^䇠<§"^H*}/~8I?^r]Z?"H*}/~䉠<§"+E+~%ٿVȼoĻ7eO@yOEԼTd^^p!rȼĻ?eO~E+&*Hz*}/~䇠<§"Ȅo"lŕ?g,V!0Ƚ l߫D#|Og,VȼĻ?eO@yOEԼ4Td^^p!rȼoĻ7eO~E+~%ٿ+]a 4Td^K@yOE "W&VKZ]]XB$=>ߩy!0^^p!rȽ?eOWMT !0^K@yO+~E+&*G^mн@yO^Hz*}W$F\/y_6YS?"lŕ?.Hz*}RCaS8$B7{ʟg,Aut/GCaS8 q "7{ʟ?"?eO !z? qԼT/~8IG^m~E+&*]] T/~䇠<§q{yHo?"lŕ?#/y_6YS^䇠<§q{/$=>߫Do?"lŕ?#/y\T ! lߩy!0^^p #|N?vaeOȽ?eO z? qԼT/~8IG^m~E+&*]] T/~䇠<§q{yHo?"lŕ?#/y_6YS@I)BI$,<\r v%BNlLW]-{;!l9܃`T=/vnbK[~2O l nzҶokvoGg.G0TU+g͖:42C@`$2u5$CRir%M6ܩN/?imVM7qDwe7$VRwTRN%l[EYX`,k)v'knsWf"jVHŲ-xhiݹ+^.*` Ыk q:boTq;vT݋z ËAzrqysQsrM6$/%ѨAA˱cgm{APMe΋bS`!uT:a<;dFGc$ V9C,sLɠu[̼|ݔ4yǙoq(m NKpR[[e16& ˘?ãʽ]ٳ[O`w%5@mt #4w0UyCYQ2\KLDzft%bz#qn"LSE½y9Y<c%Eʃ P=Z~ G*w\>'YH .IffZ j]zxsiCLd\zh{(ٍ-ew)j>4ttSNc 2c}T4_=OHKSV^Eɣ+##^վ=Թkk mtH=ѣTiY:Ãfߊm iU-&j:8XYش̚r m&Xւ@gtҶ#mЉ2a54i#WͳgVG88 k۽J{'uNضK^6*h ^ A!-X'/[FxF[=(ߨ1>+'L.}mM*eίPh!zݢ7ӽ4T$0l7xq ~ ,a,u6Y7'J7m#|{HZ[98x_ۻaiHg/rvvQ1ȒSF6Qa[sssGw̷-m4@i.i6Ng-mneze=ʔ7nXN{%IORX㹮kstxs]B-y'}1AYڋkSjK`UlӶ3\Y\ !y`]U|ϕ^j2-2p ӷ_͸8м:S]"1Gv %JY6+~S;h.2/p)9@! ضT/pf.d=kAȃi{kXL,/klkP& ym**:I8FKM|tb6aq~9 oZ"uT_$N+(;>h6|Qc(K(бpgƺp[w;zglH 9En!lU9GdTa{H4$Hޕ]O&Sʭm:smpTZu7ԁq݈V6/c܂)ݬD]P8*i A|blpYfkGKFFK-[39ܗȪNwB\52ڂ*gt(;=2&*͎TaV6Ztg;þWo"-htnرEl.+a:vFB~TUqUԈOo"Ҩ]ۂ7Gb(uvZHoE]0J}f6{N&1ρVleGUʹfɳ$YU6-^$ ϊVvݴ F$ďwy^YT8W(III䝒mw$1`N?0W H[1zll hT;Sc)BeZcEpDOPe&2Y3'ʲCA0@e̬dόݮub#않hv +Թn'*O}1Tm6/:4dYdǓ^śMf4u5LwnHWx|Q[Br0܄+,su9Q7$y?evѐ烀xM$vP7*JTִ"jҜNo+]s #y*؎dd珹sz9ö|CYvT*Ar+;O{%iɏN:_mJ`% `0!YR]?L9CUdsNj77n̩wYg,q֞AR)퍳6{VqĈc}bHŌ{:_ TrxgB7j}oҨ~˶Rhi(d\Ls1^*[1Tn]EέpB`p9SeMC.Y+}ģ:>>GΨMtIӜoέڨWJ*F;*.٨>E2Sv *lM6ʴT^Ϣ ^9ywު=OSvMO/BУS-ȔEک[ԎJ%ͰK9mnqwao7^9.M{JǵyT\r]l$:cP $o-ҝOxh=bǏϚQjJYܻd6'R)ۻen)-1R2wC(i6xsoa},Lڄ2ؐAc)5āAZм-N`Ne2~Zu/0,K]=@u.pks$&WGQcݬJ*;uUwt[aַԺYB; Sm4!ztjt>3ioRD*.nVXƁRq+-n>L필UH [H{:2xYTی-mɉ )[56]RRU/^nӵ"ì?x9߂PuJpޘtp5"MPtV6Öf86'$,/kZ*ؒ։sp 7TQu!hkFknMkx @;rav"ʺJYk'm<l7#A:'㫘9kXm B5KrNay z\ b5#8bZ{>iͷ[ӗVP<`w$ɨ9eϾYxJGNvەNx7qT^.&^uoĶp/xksl Cz܋N ˸@[솵69cJgGa6nIPlo 2 Z=*鎎'krTMRg7 L`&_ܭM՜@@erEf˷NI˻@XA-Np^ȴ>hyuf-Q9[bsV֦]`nkܤf`cxT]ج/Vr-:NB V5YC|m2 C9+kڶwhq1CT;tsn +)8_Ps6p ]exkI9lJMfG@vUIbwl` f*SMX 擞繄 s&a}){ [:LؘMhțr[4%I|҉*Z,364 o| >-; uIhc"fv# 3!:_ۙOb{CIiv/36t3wf53-2N即`IdsL}N%lm;.NiSZ{kO#Id l#D<2(6B7f}ኖ!mMkq_Y': =HBKkjmo1F gնg_ɕm.yִԌIMŶuZZ]O$;)CcMv;@Tx\qYXfFE^Z{Qq; B:-Ѧ͕-k qZ4vQ+xpIB@ǩy'SuB-{ds%PM;+6 8K"c]f^ܫtlal!gtl9kЅWetŪ\*%m;NH>hq4=J;@~{wHA#1{9BZR<0|5%JgnR D7g[]~fK4IV䍏56Ռ2mH`^+ɣUU;ݼK؀kI% Bp CUߴ 'vH򀢒rX E:v"sߊI$Bh2_^1.pI$]d76Ԅ)T\@t5R,ltZj_mL(nJMۇ9S09^!Y4rE &y*T("$nw2=ebmn1r\ͭH4UGՌQCU*mL.&w[n߷v7LR"LK{tZK*g M.-Vu i ø'{48F%O1Z R\,ֵ/Zh"#I$Y I*V+)I$!b T$2IXCRl$I! TY1I2ud-.yw1,nVZ3SXT9NFSn@Ѵq{qʝ}'r ]k$JM|OY.`MN%'Jy`~״Cfo7GG< մr {7#֣Ln6:  ~9*S<9oP+y1hͱQMx(Ʃ.D~ $2ls=kvڶl_Y0a&6 >ߛ眭J.Rn톋˃7{qŇc. 4MA7&pI{J )`حdÈ=ޘpr79>:>g)ҨMΰyny.Ӏ^~C)ryPmbV{F7}xOh{ʠ3H7xe%D+}-\ Hs r#Q^>;>`*l ǂMug"Fkr*L6q/?yk*A.y5⥎F;Vj9nm(#Xo%ː*ZI$Z:8!\9ʏlS8癬ug88-#~C,,,d.g0Y*48 UpsOh^y7mQg dQ2cTZOdD~=X0rZp"u0n" CF-qeU'i/f`uI̛vmN=US1$2{Tuѭ t,/()`$WT4GH;NPﶛFK卩0``5_mT4շmv8h=88*8Ba2qȕ ԑi o' AnN0켙Jc DBV|#@vhc"An) lCi*k\؄%9 8/naUS:_hGW*l|8ߩ t-Yw-6аE CLDbN|j4"ح| KNNC-MσR-M] Í:cF/GPQ. L&ѡWiv&0ӵs}w;qz;&*> đh85MǓEbV  5b4⚏DL]Mfx^ȜFmd9ZOJ<`$/Af`pmM[y' w贞'V=Nhe3,w|[*#ejF 88'jSNyEq:**p>LUdU{ZTi1pcZ֓wfi:;:h]ď]L\]25܈s 'XS\ Czir~LmXhGdRv ժ$a 4M6#)<6aŭ%4fQfk."N@вMybdaq&ֹe oc5$f{sgg{|=Mm*z9VfRF\[mѫbѪB'lԞHH.9&"Fj^^4=(c$cfA{ҩ׷쵁s"k5lTM9i,ā{sq)^n6jU$N!ְf6 {LH ]u #$bGxn$' ,x 7L/k@3URZ=׵2F!g;^6GN_@We[o:ׁ0SD$E%֮В,b nRPaV8S[ */sxWX ; ?aڍ糤7Ȳ(lWT4*~#eŨkgl Huv~UkJ]@2<ʼgW6zTx'ꁰ@n\S2=8[GL]Qgp5&,zhGl fݙH=J~yoj3fH s mQl.6|Ev8kB5~to 2V]S0~Keo T,6gS|&<,%]!zM\Պc5r[Tk J 7 0:sdѼQ$e+*}{=lw &ĕp;eZjr(3~Y7= b-ǵM  [M

2UÚCiֽzd90\"OXf-IZ1 2!_gՒ^;B6z"sPɺ0okTΨ#Hê;mbrɻ vW=]QyI8d>PrB܋K_+4smYM,{&l`rS4A^$v'X0/x/*6G):Y-: 92lը<ܯ9|堶<_ڻ+7P[i>u(=4[XFn羵ijXFD9|,oֈn6t)Gz[!]J鰲4׉odvӰԆIX8D\lܦA]UKOW缓ҧ㪎c$biTD8܃Zk{R F t(Tϼo/+i= vMcCm!SrQ́p>yZȜz7{H ޡ'Sh>{XTyL{ 5m`4U-ǜD'7diYf^%K&L f aYyͻ*4(wٻߙ"+41͸f &Gj͢ܟV2m:'P*50.{ #\:A-n7!]."xqDjCMMPlηf%H<faѴ1걦YI1oMRaܹ1W썢UڪpmnDz{"kHcVGH:-$_h7j7ACze eq~˩kmL)Ѩjè'A:gK#KB|_2 Ԍ(cA$k{z뀹'eZ cvmeg` +q'XP !ZfZJVѶתm)2@q\xE]vm56r[ADI!cDJmcL<΍j٭-czB(/ 'Zƚ'q͸Bg^eyqZmTx?Ub?_v'W75|dcj턚D nY*;'Sn^yLÅQ]J\h $h x)K6dҔɔ2 W7'o$g+mH*gIݎoo;aob=jV&U=a = m6~@ګU}vSsI Z6 `J|+ 8|O$H}|zSv+ -Ido ' -pǿ]_ч #g]gX>bQIJF#v.Ǫ[i~V_';5YR`<Ռ]!=ZN6YVT@&Uϫi 0妐ۆGFBFǛoÇ]78G8#pZ| [C<1`.{Z4yލُ,z'3FwVa3ZHAH=훩2nX3>lm8g+;«::Y;o#1:\s$w/d{bƣGYΎvnEz>A6\?8GRV{:E/GhV͍bjNx-s `ps!8qުk剃P;sZ%ndopI1~MSk `A+mQ͇-  fga;Q&v8>u(Ls\[Am{6ò6N#Hi87I^o?C`ڪ?k. TOKSRо(f,xO) 4Bإ^1v~ugZF&d]r*)%g" .(lZ' I8eiաN4DxySٲ7&A.@̕\nOem-ݠ 6'SԨrpm%5WQpEf`msJPIu;ytALC}K䚏ۙXxe)UvGy, zz6msD@_x`z{#:83%{)}UW4 !mCiqT465繌sNZ%dn^' z|qDxʆaVfQX +_>L .̽R%y46ktRm"bSnsP mN h 1i׽ ӧYn#t*=jMGUx 9:ie NR^m^ LQKW&Y;ڄ*"\Ƒd`=(' 4|Ni!W .J sMR 39*{ci]F K4:pH.s\Иኌ\9ozTLn՗!X4jn\FDI {mMsrqDZ?m=)Z eؽJirCw>^.JL঵J@B"-Tj: =)±X,4㢿lL}^qxM+a( ndyTFS:gT*;tZ6Q{[a֟[+Qz2]Y=7ըwYM:)lcܨծr&~LT8e:e}iU$;'چtt^Zݭ߱=͝$IWSuno*u7VPoYX7u7Ҽ]Rl~z͵/fWPv٣SCpKs34}MjΓaBB&1ŴPڍHIwޔͿ&*)ZA!bd8[bSg*l|*&l4..$D+6T\qi [1ۀL5%r ړHBeX5 &Ɏc2_YԨyua/^qo9wrø_!ֳ떳XhS}X A w{soX /#S"yk=Mͣhp-uZΜm`gz5jTs\rJE"6!e{KfSFW0oq tK+q; %8z%fxW[ل# /mc*S#tiܩN1 i3K@0j3e>WsObPCrUYNW3Kyk@Bu+@;ַnܦ\$gr}l6ۨ`R*'tȪsJMa35O^I N՘Xm^մL8o`Uv~k-rsʍިשjݡރ3x8z nT;ܸqEס4wS-C.8٭;=e\+ F<y賷y?${72o[0n/]۴ZnK}) j ) h)U'lν;~ƘpVRRmw_( r,D ,MJTR;,C^c(}x̕640 j*:C.q8 @L+?y7/߁WvmEk>KY'.Gh}SRwSA蓔ki6|g`3s$-|-ܮw4 dnj܉Ҕq+k .W-YKSfݭ\%@u+T(lEHϻ@KT ;FM~~'88꫌s펣X$y: ) dlE\ɶگEB`.\vmUwo6;A-I=+Z0舟*M~6 @ Mܫt)4\`N|O-s6=E2 .nvfVFCRɉ2/R͝OBOmvv 62UJ7R+lm l&7pEYG˝|ZKHU.|E<.nW$!䖃v[ &umjߖD6ZD i Ryon!̑m VnGR&?Ĕ n|G3Z|#uf{@B[9WjNOBĘ}iRhkhaqZ(r Z0x1Ju+rڎIpBav.kT!tUR 8nI7+Kh[nZC7xsͯpqsGzM,sopr4 ޢƉ}r+˩1* {׳Qh w+x`GSrkE9\יn16 1Vugv>󽐰BMب>vF.qZ8+Z?U!긾owT6zm_Ii;qPq n^I$rb+w7J\)LZMA7u7Ҽ]Rl~z %3M:'|GkBX){x̾ҢKW:O g r&)aM3yGE04 I" ESS2"fʀn"Eױ^ˋQ&TFgM1$ZA{ aV9flGi勺 6ݫiMt-,s ѯJIv+P̗+03羢#VT7BQnfҨ*h<EϕXդ&wˊȵ[Uw'+.k(J6fZB$2#μTRh^·WhU:/ۿ!M Lθyjs#{(PEEbxZB*ֆ [GR`q-VU6Yުƙ1oR}ۇt5q B=W{]$ dd6>ܻ3\`X1,vS=1G#m mjkmPe=s8x r~p;ګP60qq SWu[G`dUV>8lN"V9B^0k!Y5TplrV#ބ, nQ`7[WiCcܓ;*sv |,6^z?est[+$e;:WGVi(icԎ.J껭`Nn8D $tTH>RRp|yOensx4u-Wُ* ߬٪qul\&̦#>:L9Kkp,mb'x4YVvS54@ ;;,:,uí@pi& X{M֪Z48b`ژ+5nјq1~Lybp*5MBAS69 6q1!flYG5M˖QD"Ƶ(]2p`n;5Xad+%*[y8*[MwUp٠giJkIE䑶Tk6|sBTP~Ҿ i ɭٕJoR{$9YB ^Vq|4ȓ~.Clk\Ѻ,'gbٛh/]noY9,-˭WdBc)G$*ypCcUbR,*HL-pޤbfy!y;.Moh2ˎ+<,;-kӼ־w}b-^"x虲:b[vFE& {O%5eF MOiʼVڽU) (;;k {q[i߷vՔqxVBoo?Z暎@A}98lVe\lORP3qi!B>`D{aܪd.D\8bݡ)1+,do9piu,vaht6fTiӛs[k);*'y7k4/c8NRTʠTLNGJz^ԛ#|5Ӗmh!)TkR`Oh皔-R*֐@*+бL׵ *L;7BX xaQWEԞ؂F[[RpO1,z+ic|.ZCa#=V\yaOm4τ:L qWyF]OwI"' [n#J:Y | Dvr1fpomXB췓*S.M-晷.nG \Ɵb=>M֘q"5sH/kvpD k$Eo7tGobx}(0VI_J]'c}*=BDR>򟏳)?Az$IhB's*u>;T3*}̖ޛ<厖or-K ZLJ"cA]* 3$-Lm[u{\V WԬ?ʵ˚$nDS1@AkxtL+qY Uj*l6(BC3xམh?n`{H8Qi@, -謵Iڈe'k|+ lF'H66…6Qu:s7 ׿e.Zdegi[&:mƶ&z6)e(˯,yE-%!Rڦ(FtLM AuFQnŪmL][H c5M Ky*_#9 VQ17oRM^xVf翚ӳ o |eWM@j> 2P E[[T*UyGp8y}ZGc^+!h n `v1| h;TghQ.wQN_BSQh8m5jlԶvʕ,zV;ECm9i4j[W,soh-ȋF +fKLctX .⍦\XE+s 8I홂zL8:$r~J m b"\K9xĸ zOOfݪu^Z_]{m6&H8ASpm2ݭ-vZT.Zr mQ8hi`cq9{)US6zS3p6fѸ(CZ4gmyy^{+m@lVqq{:'hF]NaT]|-* 1ͣhm{8$0 m#;ou4T3B]+#"#%7ӸptH_$d{m >y5eұYMSb`-_%#w[4wŽv+lŚ=;zOۈV 4\hΝ_;V6M[E:#:瀹]O:ti9lC{Z6Ϭ7y`^ĀVHlhL;Z\*0f`֦/BLJյ6'`RSa+^ƇUpH0Y. 3}C5žS¼\`H庬k0Wl&I)QEC3pNp^ݕդw:BN קOe:>ةR|"JQD.qj_iK\ebrY dqkQ*O'STO;xQ I£EseJU.Io8—mcOeFBH`/٪:xMq!rQzKE;CXr{6bp뾢-RM w%2|loy&mT^$u9 oRޓ1"3QCvLFE]lme!{<^LkKC}%PR(lfZ3zͪڴv!0í_MRfl7sshj};M -{6IslO&4 ex Gb,o-lC23fTl$,yW|ڻ)ZZ ?/saf/ݨL.(hIص (I'Kgp6eQP ]mΗRlpdSi;5@gxfa  rOc_$o C8=|QxW=2+5< {sȬl[&ݥ$[8kmNL5`\ּJs4ș1maz\m̝F鋃ULb8+ٝY_qYk͑g[qJpp.l=ւأW0cm8 ${sbm9: >QZPOo2f纑q&],e9A.63L!kM7橩hnzΰsu鋸HӭۙM͊ͶT&( Խ@ѫztw*>ͼ$!YehժYcUlQb P~! p<'s܀cҼ{GD]z ;Q R -g Tp?TR]>ܝ+ew|e\`I>XOVbeKiGCʎ6[6HI?sPOborU ۶GDZ BmNww:ӷ55u@FHjT*Ce|Xb`[-V> 5岹ɠ{i8Rި~i/K6%/0Z]R@=f[im[wcZo)\+u@AuDD{6,dd!5I-@x7 Xaq tljÌlxִGw7RT$q& q;suVts$b75\o  }ʭgs6.~V6G݌u{*PpI,k\ܬq4i G&ZRCh$qu#A0 )Rje10qrl;;j,ky4:^ϸ{c՚9sAkiEШI 2m\[j418^jPUګ8two7Jw56.-[Xֵf+d=>T2粒8.yvnru:gbySUVvx32Gd샔 7Kv-F /_*˙#ό/kaCgkx@\\nS$ ,)vNzQBfiiyI*N*?oYWAS$a#mT2͹ Zi'b.B܇C)9:8v 6CrNLغ=GImfyjEzMKuD*:R]Ȗ_V\KA ف6UbW5(#{ +@98-f6We _~3,jc v@o΄w/duFWURu/kŤ\-m[U>ZZo൮RMJ޺Mi*RGS4?# ɷ9\Kd#--$j "ha{1cϊe¢V Vb:A:IIj,KM0x .kmcQdf7-3IY0aqxv榜睆Ee aEMvWFN) gWFFK Acjs^ 6ʨ"a7]VF@,yޢN`46͏F*Mqc`׊_#y#UghWdo6wgR@=ͩDK(UpmRY`e S D3U4 f<ÈWm=KUGnAqB}m;J m她>Y g,.~O>ٽ֜x5(cMOieFa!=DbnsKA';toH= CMJWE9ք(9W,w-$ҬݐqY0#$>Q{ QjH֮ڎ. oR:$۠n;h4$k[n=!3v'%0b/٪D '`O;?5oj$FϩTSۙG߃0q>7T kH;-1R'1۹gq+YMGCPA䅑k!/[N,l jfn;j.`Z3]Bu{U*麈|U)[?ST/q_6/Yyzܢ_l^I$j+ɲtv*zptRU>_|PΓǘ/':ܟO7mls׬Rrg}9zӧ$6 oz>̰9/CHb؋GH" .٬mVsZ, [Ƨzwހ28x#V[]- B@IoΨfQU$vp^vgv$:* ck8ML]ރJLxB+7caM@^}L6kJS!+ ]uj 'xi"]%I-NQ# ,3\ -UX8Eօͩh/#Ss]wljtyg`pcC`LqG4@b"2ujf02l^抡q.9ZtމvuC6@ZF.&ɵ H`ke c#BF?l\| 3܄4qq[s]:;FS7 Ah [ w=db4Qy[!h:Z2j lxv[T-|cecjn0*Qp$ /W'}~+_٪5X$qB\KZ E?%fnH IRT| cEjTy9x;@s@3F](Qc 7Ro)7x[Qy^ F1 'ʼSvy: 'MVҧj1R=:9+,۱`2m_к?U9BZn vv9?W/EA\ğ ] ]])$wRϴno?ɓ1~Ps%!&:VL <*k1ȃqcVqs Y]hn79,-":ALTR9ԶqibF0㏝RalhT-~MG끫3{*w`*:k@9dF|+uiU#.6]#I2#&"W0s4T67nJM`_ A(3gFщ<!c6̛Z^aELJyKKŅ Rsn&*kpOksd k 5 ֖Pɦ0R]\sԲkDgn` AY9$פ!2n|:@54-[tV@ siˊٶjBFkRIYNu80L!T6{  E:LdfbX,5^(l*A$1 _bzyK>HT;u8=59i BkA>O$ͮpʄm6$Lvܤ? [&˵n'Nn06`'9 @{2HpjӪQJ7IdRE$B[džSe2o mO;}DRqz}$<+OUw[["uӋ36VҁةL[iք-//QlL$.tB˔WnnAQmaGV M͑*7Z]fM@ݱhb<(S {!BivBqZ(>qZqT| u7fx2y*tn/8zJ*COBGr(}LEؽI$4!WC֦*U }:0A'_L/Yy&G w\3zͳ3ҦKc5vʬ K]UէWXLqDb,˃ gGZF9(#٢q5$3>`wݏƃ/-t5 {Y|0Sa2:x[An&FmObu9#K2;('\&1S[J6T%` ťXx8Ʌ^U reg61S#4شPkEQ\oڪwZ;pՌM}r8T^$%aGm[lK^#2 _jIy0::ݔMAiYw6j w*lwL0cu8&,p<, {7&b5 ԴtYWv2Cz7&u,-a'y9 W([^շT;6WiyLTޙ-ً=SU؞  <=ʛ&Hli)$ҝVI$b!YpÑb9-TqCW;CG|]ckK3`c{",;qI kɾj%S;fHuVxma,ާg׵>Ujo9v  zٴm4ZnUhNU~w)ȝIKH@W#C!q͏a,%Lr< LG$}=-vJO"%]7`c]ˊɢJ`SsD0_|PΓaByKyɟ/'<=X1*-A /xܵ־㫔.ĥAd9A=C&21~Bfi.QMg4溧.X)lVrMGG\lfRapٶQqdGt!$X2+PP=,SJm9i[R4oΡQڙ-p znrBNyh8DJ#A7;B (k|6#51; A|I? 9A2ժ`b.l-cT]/isEv +F~Nm5 .%qi@㾇:A(s ܷFf;\͒¥GS3㖸_R4\8_6Pr7rEFOv}gUu,i/[^5su G{E:ͧΐ8(.T|55=Q[ck<2A!tUӾ%Ë3#Z6d}Sf~;k MDÇH/Kvf6spWAa@u \0m{E'ЯMsh9|iG ga'ivF˞ ln2Fv5UUh-#3⡪3.BWO-L 9( 8ALUMŮPM?m*Y՞ N\zKj]͍85) :N)(V#r^G6:[Xp-poEжHi.6̻_*z9 s8L]ssT\k:uoeڍ]+1xx`-s&ЧvUjd8q^o-kAL.amٍ:a<3gГ˜yCas(O],R GQuP 07'utRG4=w,̷Nos20}R~ͳm7]J}xUٛR+Ic"^1+q!Puvꁏ:u{QԪ%`F;ݎچkvܸ k'rv1qc3ILd>]Phw%P[>˳Pq!Αԛ )-MA2LWwNh$^eUF<Bqp45>LtH2>o ]A$\I'Y9aI8\,&\qq 5yDxTv9T|)NL6CX@@\ ,=;=gls]8ܛVS$7b,A',nf{г؅ Mayܫ>o;ͨA:\\("Iܪ7u"Ƚr@$8*vg̴$2Z~!h kϑM!-Dme`@k9lBgtskP|LH%]jhQ3s% RG9>.+kvZC!{G 8]Υ5~&eo@"YH5@%l^E@Q٪d6#oYOIdpڕ` eGZHY^_%rP%.$Kժw'Fe 11YѝlwDppU*݌tIyxFns׺ORrT?+i,Y}`&yQ@w`H#"Rh}_l=^5|&^Hmۻjkq=>eg70f=쫲m:#ʹw)0 w"-@qrdW66ŨvXn*#rH<5=G%Ð=W{Mm+U佣f4 &Vim|ZƎM7I^DӪe،.6O_|:X̂aV9RHԡ0%Шmf&zѻ.hוn5ּ88W+LǩQS"DBj0t6joܦLC+ZM$HXLdɌ>ufBJQJ)٬! $S&l{G[8*wBssv.AVNF`GrC7a Ԣb|9t#ȡ)n{'&Bf KRɔ3Ǔwmm2i%\8ۭ=V: srgB*ΗKv/mxF ~kI$4!WG󳤪U<*]*>#Tot|^v{O@(*g}Խe*lAܣG#j~+g^`o߅UO+jxTxCӿl-Gh+R}3B%S!%NJ[cl_SL- =r;Ep7lD.Sgg㼘T0,lcX9٫fN:T; kn <,$/9'X%iU koD5v8E&W:egom7s|ZGzϐ\)RkKp0;|SvM{p#=a&դp.0W?q+Nk%Kk,Os596*[jEC m'v ZDK`_b3gu1fTѮ}Ǯ&kE6V%t8RYv`g?QH;P_M{ߑ +gq.cߺKM"lSaEF9 4+өMc``Fj-kjӁipp(y!74mWČ.(ٖ#osN9S'B~ţ2|[ugT߱2]{ϹC#he{!>|P4vq1]Dt 65 >u) _6q`>8q8O}61sHJx$oNx#psRh2cRi-RB7*[*{C8Bm`|^v!L oNlsRBJj . HtTsA3X%}"CbG Q'uԑ%NlB>tRm6Ri'1`h)dL3B;u1mI}9;n in ]#1I  0Y`!npoScL_2E+,& ϑe @&N'BT*alT\,g ;[N,12!ء-f  F#{*΢ YnK7õX[?)voL-_y3vu_4=7GT^6ȼ\6kmu:̨au-&E-]bpc갴 ܼ͎hSUH7~!tBAqUÍ{vI# Li/*uyGj;h={Jkkm~$A~X Vy?.LZ6,yuG,WvHeu8 [.ǑkM%IҖ0suZNYoQj;fXr$lݦ2X2x+t֣L xo#Es*Ӗ5vMkd˾ wвH#vݥ6GRdRP2rR{h!S&R!E  d,{j5, 8`u6*IS\xd,&N"/<6MB8OsE+ 5rF\7chpՕ?H:*q&*{{|S@Ͱ \y^y ߴyI$TЄ!]cURgITRUA_|'jt|^(RwC*4}9Ubq߶W߶Wp5AK ""Vι*ga -A+w5{%E=!:\jUst].|lN+mژwZ[GiMHKʥm۳oPa8NcC:wMXIm*Luvz2Uý[9f:(tSlj4H8d-̢E NO*UW{r[N* 6@'1U:]J0$9꣉mL@Ms ٨h'\U s*Haq*Fj2I!eU]H "\.8ܒ#$[#kYI@,,Ӯ Lg`ֹ*I0:Az`x+djI9L+ px*ݿV)Twb{SdD*WB77|'np,4 ثHTP։DqbsP74B[/7U4)DChif6 `[%@'C( U7-6*EعC^ h5 a*ԶqB2d¼/e`7p)n*7)/&w(={iC(1D{l}u) :ɹQJ鐅B7 $ `ϊ{[ddBX7{S n}B 1r )3DtO l&ɔUmOTF*ꮸ<:*3A.A@^o"xTWm`+lM4mwuW}z`ߡzYmu*,~yʕ|#1Ui|gyx\}ݚszퟶ}'M9zK쾳p6K%Kd_gJ'6uŪ+tSښހ-yx/IQlxmsk/Us| uXaV6~(uj֢Tr\u (l׮4F}7HZX0Ma9a A~8f3N$9TByj郺Tٱ|o7zMpשrM1Y'u.D5A si j{tBֲZƊs]n!A~Y咑H- IóQIL##H:vQJ="|6\Ӫ8MtIsÈAŮHc!s>Y:sw7M \;6 ~mM:nečAoJeR6?b4Ag6 D=t!6>8UTM/BpAfvlٖ!OgZR`]8^+=[{g6O"8^U+Šn W@S; UwI٨!{N`|AMXXFVS|GW[NlS-mrT mlaՋB?# k58xFgR{;sHXHcMjC6˙L^ !'eF11H= }c< 5(׶e ;`ۨS E^,cF 5Cq\UpnSlWtև[rj! %4Y;NS۫i 5 s[-GiH&h5&XL@Lt%d8"DCu&.Ĕ'I@&TD&D2p$n8h 9,L$.q;ajt$($n L(I$!@X*k NVQN%*9:g%l%2E"L8&@ LOWUu*ꮺ<:.3d^y#iھz#iھzI$!\;QU*اJ0Pg]韶}zg~ ŏϹRcGܩQw?Vwf~;׬g^JMqkjbvUE bZ1ͱ ZITG(;&&tr\F r$Tεà葛MZ۸av^Ӵ7Li~ͶNk1f k4% ,\{A{n+fR8ٯ7mta~Zؑ8-j`zL9-B'Qv뻰^%m6j-#\$lOPfU)\sakӬH$:)%$! < `2--x- ZUczqQ.uNs\ey~ <wfN&Q qI89B V{ ^iEBI8= {P A\*)Sw:NklTnS %zU1 >e+ѼYp[8Fa{[8F@@S+b>M!9^*Vvx.6T+c ݽJn@u'HXmY^nkmUy} K#+chG{0>F`˒cb2K hN0昞[ Jov6DGZǶ9Y7@!%沙,A I,:7y6T"\&C~&P_vi5J8q OaP x+ax_!s d@* ӢNWmf`MwTvRd +vݜFl@L:4`OYPKclFn eT]BB T$޽=D0Sm]Zfe{Ze#7:am] !tE> V۽N "9$!5bB6<`$2d]"1)i$$!`Jh&fIK e4,LHBI$!Bt'B\t! Y5&8J雤S'L&1tŀ3*U]pytJ]rg{%^`ߡzui6O !zŏ9RcGܩQw?Vwf~;׬g^I$jb'W!vkMD9_98P7N`^4[JNAC7OX K\ӘGms$ 6ζT,.7;4@!}* o+t{L:8h*l6*dI U䁪ȌDZ.ө {l,ذ p{9 \54Uӽ$IW9P'Id Zav+R!^q}1nw̿TIÍ,Wn`a7+ֻ`OJHjwl ,E3 TBW}b s:i%^Lgz׻F&;T )! %T{MT\]! rWIkTt\+8T&ӁK04<~;^JNk,H(rkdZvVFWg69)`KPFvW쇶f *ml}:;/]w-#4؅ )*d)Q" kHH7*6[J%$XWY˰9]EAWD{#M& qE+Fv2vӵ .p&F?h2;c8ȾWByOj3g[y7LmUsDן쏕+ ,>s7M16Z˜Z7RK'pKaqY2h̨t,.vo@!;{vy4z|I赛dNFWBq)RddGZʄ 22I+ST029st2ILP IH k\ &NL K )$HB$I!BI$!BI'B I$B 3BdN,,RkZR<.SPlGy^}7ڵ+ToVe{ӱ|hWG`\Ѹ"+Ѹʢ,R  ~ QfEct^5ཚ/rLI"ʲ79ڦ4naRB{)D/:zN^iԘ5l+ʭ${Mqj$m*E^u5\A{z'Yr;5=TO>Rz*"TI6U^_`{ק:s_FV)ҰVE$gLIʱ;ubi9Xd,+onbET W4Opi^DUg4.k`bjPW[~ERBiR> נYyt<ĴM|]2HBaJttOtL)7dȕJq"$!A#e>`*X"I$$[ d,$! ʈ I$t!Bd,aa$IYX(%`]$$,$2t! Բp=JڮȓJ$ʔOoBeӱ|<^W;3̽TI$4!Wotw@Tb;*`Bwy4^i}yc޽d^5:{wQI% srzݩlխY\M2zI$! $HB$2HBA_-м9]z`@u:?ĕWɫ*c2 Lvo9tYd~e3TsjOת9c@%1%rn^Omuݖ{cy (ICuM(uM4;G4LRzG Rxq6SXsY^Uz[@~zul}1/MvꍡLt6bNtT$pcFD*Ȳ2^FWi׍3cz~N-6ܒҲX>7gNJ|%~4 A s&ԒUgGa"dC 6ĬzF2rn!awX@X1FX5.I"لMUyD"Mdv1|XV-d!kSl`"<m2yl[]>+ɭJ#?`q,VxBBE (B[) r *t%؁=j6nmW,ZI崡 M`gHYޓakI\`akKkA$2d]vd5R:Ѽ1wgΪY%q|.qNeYUX^5hCZ:TrɵV樿 Is/LpU9E;mZL[۔^>McpkD铡 d do2I%"- R)[HJ#LI! +)M'@)$HBĨI$;( $d!eH@I$!BI'Bp=K+ԭ<]UyJ]r7̡K2}iؾe+֝TI$4!Wotw@ThܩJq֣1 t>3y4^vO{7rI)BI$! $HB$I!BhF#L麁3/GWY&7LCLA[F.GҴ`۬!xɛU ]>`" +J+[ Ul׹Rtxv-M"ln'8;gnRx2AfJ/_]fTI3|Nsc҇e& `G 7iyNH,ە(~(i?%rjlݗ:4 !Ƶx.ɜOZ[3ꂛwwAqLNl2^W+r5vXkfEnTη>] #$kl.N!hUNKa!,m<[7jv`e$l{UjPxÁZF-"xB9!cA_J|ʐ֑N<:Va 0R豎qmߛM*|RRoQ!UJ}*B)}yicGGU*n{]%zj%l6O=/ԒI%54!WIsR(babrJ.D]9Cپ+v]]J:H|p\U@Co`=)xީ ϩʴ=4vZH%-W4Ǝ !CGcET/ף,/M ,AGf [%o{=^7GY^Yk1"_RJף{Լn^Py?6o(,AU+cR7/ף{hu5pmEjB3nrwWGcEs[a˶sS*Sc 6uq -3>=n^rn^P֐= =eY6HfU쓎H#EgGcE4r=YKCei,  ? 4m:R6b)U]GcNõUkd߆ad&?-Ҩ\W{!yC[V a$vhShp9-;ڎ6mxt]-qxsmm'WL[Z4)VUmi|OSפVIҫXgXM,]3 ͙B[KR z)Ýт\zl?MMޛ&G:\2<%E$ )WM tѦ$u'7)Bc9$0A_rfW w-lm{X;" `g ]RI$:#yA *n"¶)I$nWG[gwI$nWvGWgw=?hiIM9dNu#tRڎZG^ָB ?ۿw88ܓrNI:7Nn*lӦ1h` ?ۿdIDo7U!ymQUE$NӢ7¶(+ln"%,$pZn)#X,xk^ZC_|.##cccDo WZS%. 孍s0$UO5,͞Hv)IIWLX$dR5Ey4|/ X A 5Wnhrhf*" }rs6K^I3VvT9H8@KLKij"6S lqkPmI2lTEr!l|*֠Κu4Ji>'z*[ -?Qz4]+$d!LTB`"I+rXn BI$ x$I@dVI$BAʀ+3I$BI$!bP $HB' $@i){tB[q#$f[+qRNI)IJE5I$B!$IBI$!BI$!IJ><:TTåEu`zmi|OU[nmS)|Փ6o8A۞ite]\wQ\s2o1ۨ{nT֦*8&ȋ(3f{IxuW88;qE$5j(l?IFײWd`pJ6EiJ 9u%tAqa…iZdDkcv1:J}3@KxXD=dңYa{76͍S sH%.K`;ɼֶ,M"LJٶ?b^_F-uB < -sb1ev.4ki} XF[.,Fy+* s"ٟ3aPq#䞔΃Al\|=&J• ݼ֗wRQN^ Vų Eav@c`^@"2:_ȜQdʹ&PLv.B xXvRF,iбS6}Y pAMou#TkIG }ξO]ݡJ%ozc>:7@o/|>9#waooa8^^w"-OoZ4&K=)2As3^5T! İ㝢(cg(5kdz*.irl*:FĀ1rMOTӅRJ &<" xhy}018G:uBD;{.)cӺDޮŵSm/M=ʔ5%p>olm!آ}{HiM+7RӜ٪ ꆕ!샒Khm35CRJf cubL=RiW%eSʼUڨƌ:ʶڌxiX#de%F̬LHB, $HB$I!BI$!Bt$!BI$! $HB$.mpPVzT*Q}S)[Svz*gnfJ:Wl3c=R.!Jgu r)g 0-(!_M{b (nV7詴|7[U]. 2LSuz+.xz4-%V$U"eI$B!ti+}BIB!2IB!2I!BI'B!2IB!2I'B$! $$!B$2! Ꞻ;>b]UGrlT %mj5G6m՚I$B'L!BI'L!BI$! ҹ $!`qHK+EUi(Lv-il8ZY6z5qs1HU).;%9&l"oAxDQ *}H`:y9}V/# EVEYFcoOjکr^dv>wBmhu0IP֒ ?: [/Kko~.e*{U]ܧӫ=="4ݨ1^G-}/Bp1}EctCd)h'QmPηA9^=]hPWSiC\{`׃{%۶=k 2:{D?dpĶh:ysiμtZ%?#IUk>stream endstream endobj 1862 0 obj <>stream endstream endobj 1856 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.503 Tw 10 0 0 10 70.8661 724.8299 Tm [(\023\024\035\031\004\036\027\027\t\036 )0.6(\021\030\036\b\n\036\030\027\t\036 )0.5(\007\026\027\027\t\036, )0.5(\023\030\036\007\f\021\026\r\035\036\027\027\t\036 )]TJ 0.457 Tw 0 -1.218 TD (\r)Tj /Span<>> BDC ( )Tj EMC (\r\017\007\036 \253\022\031\002\026\273, \024\002\030\026\002\026\021\t\r\ \026\035\017\f\034 \027\036\023\024\f\030\036\007\f\021\r\036\027\027\024\ )Tj 0.217 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC [(\031\035\034\021\030\026\r\031\022\024\r\024\n \023\030\017\002\024\030\ \036 )0.5(\017\035\017 \027\026)]TJ /Span<>> BDC ( )Tj EMC 15.76 0 Td [(\022\024\n\023\034\033\021\036\030\036 )0.5(\f\024 )]TJ 0 Tw -15.76 -1.218 Td (\f\023\036\006\017\026\035\017\017\030\024\r\026\027\027\t\n \023\030\024\ \020\030\026\n\n\027\t\n \024\002\036\f\023\036\004\036\027\017\036\n.)Tj -0.008 Tc 0.127 Tw T* [(\210\021\007\036\035\034\027\024 \024\021\n\036\021\017\n, \004\021\024 \ \r\f\036 \026\027\026\021\024\n\017\004\036\f\022\017\036 \f\021\030\031\ \022\021\031\030\t,)-8( )]TJ -0.055 Tw T* (\024\023\030\036\007\036\035\016\036\n\t\036 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (2D \224\217\211\003\222, \r\017\031\026\035\017\017\030\024\r\026\035\017\ \f\034 \017)Tj /Span<>> BDC ( )Tj EMC [(\023\030\017)-8( )]TJ 0 Tw 0 -1.218 TD (\030\036\022\024\027\f\021\030\031\022\006\017\017 \021\030\036\b\n\036\030\ \027\024\020\024 \017\024\002\030\026\032\036\027\017\016 \(\217\017\f.\ )Tj /Span<>> BDC ( )Tj EMC (4\).)Tj 0 Tc 0.328 Tw 23.244 7.307 Td (\210\007\027\026\022\024 \r)Tj /Span<>> BDC ( )Tj EMC (\f\035\031\004\026\036 \021\030\036\b\n\036\030\027\024\020\024 \017\024\ \002\030\026\032\036\027\017\016 \027\036\023\024)Tj 0 Tw (-)Tj 0.397 Tw 0 -1.218 TD (\f\030\036\007\f\021\r\036\027\027\024 \024\006\036\027\017\r\026\035\017\ \f\034 \n\t\001\036\004\027\t\036 \r\024\035\024\022\027\026 \027\026)Tj 0 Tw (-)Tj 0.389 Tw T* (\030\031\032\027\024\020\024 \f\235\017\027\022\021\036\030\026 \f)Tj /Span<>> BDC ( )Tj EMC (\024\023\030\036\007\036\035\036\027\017\036\n \030\026\n\036\030\026 \036\ \020\024 )Tj 0.025 Tw T* (\007\036\235\036\022\021\026 \017)Tj /Span<>> BDC ( )Tj EMC (\021\024\004\027\024\020\024 \031\020\035\026 \007\036\235\036\022\021\026\ \027\026)Tj /Span<>> BDC ( )Tj EMC (\026\022\f\017\026\035\034\027\024\n \f\036\004\036)Tj 0 Tw (-)Tj 0.098 Tw T* (\027\017\017. \203\026\030\031\032\027\t\005 \f\235\017\027\022\021\036\030\ \r\t\016\r\035\016\036\021\f\016 \r)Tj /Span<>> BDC ( )Tj EMC (\r\017\007\036 \022\024\035\034\006\026 )Tj 0.092 Tw T* (\f\030\036\007\027\036\005 \017\035\017 \023\024\r\t\001\036\027\027\024\ \005 \220\b\024\020\036\027\027\024\f\021\017, \030\026\f\023\024\035\024\ \032\036\027)Tj 0 Tw (-)Tj 0.019 Tw 0 -1.218 TD (\027\024\020\024 \r)Tj /Span<>> BDC ( )Tj EMC (\f\030\036\007\027\036\005 \017)Tj /Span<>> BDC ( )Tj EMC (\007\017\f\021\026\035\034\027\024\005 \004\026\f\021\017 \026\027\026\035\ \034\027\024\020\024 \022\026\027\026\035\026 )Tj 0.109 Tw 0 -1.218 TD (\f)Tj /Span<>> BDC ( )Tj EMC (\027\026\035\017\004\017\036\n \007\017\235\235\036\030\036\027\006\017\030\ \024\r\022\017 \027\026)Tj /Span<>> BDC ( )Tj EMC (\023\031\004\022\017 \023\024\007\022\024\032\027\024\005, )Tj 0 Tw T* (\023\024\r\036\030\b\027\024\f\021\027\024\005 \017)Tj /Span<>> BDC ( )Tj EMC (\020\035\031\002\024\022\024\005 \023\024\030\006\017\017.)Tj 0.109 Tw T* (\210\006\036\027\017\r\026\035\f\016 \007\036\235\036\022\021 \n\t\001\036\ \004\027\t\b \r\024\035\024\022\024\027 \r\027\031\021\030\036\027\027\036\ \020\024 )Tj 0.231 Tw T* [(\f\235\017\027\022\021\036\030\026, )0.6(\022\024\021\024\030\t\005 )0.5(\r\t\016\r\035\016\036\021\f\016 )0.6(\r)]TJ /Span<>> BDC ( )Tj EMC 15.134 0 Td [(\r\017\007\036 )0.5(\027\026\030\031\001\036\027\017\016 )]TJ 0.467 Tw -15.134 -1.218 Td (\006\036\035\024\f\021\027\024\f\021\017 \026\027\220\b\024\020\036\027\027\ \024\020\024 \022\024\035\034\006\026 \027\026)Tj /Span<>> BDC ( )Tj EMC (\026\022\f\017\026\035\034\027\024\005 )Tj 0.326 Tw 0 -1.218 TD (\023\035\024\f\022\024\f\021\017 \f)Tj /Span<>> BDC ( )Tj EMC (\024\023\030\036\007\036\035\036\027\017\036\n \021\024\004\027\024\020\024\ \031\020\035\026 \030\026\030\t\r\026. )Tj 0.027 Tw 0 -1.218 TD (\215\030\017)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\n \n\t\001\036\004\027\t\036 \r\024\035\024\022\027\026 \035\ \036\r\024\005 \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\026\r\024\005 \027\024\032\022\017/)Tj 0.064 Tw 0 -1.218 TD [(\023\031\004\022\024\r m. lev)-15(a)15(t)17(or ani \024\002\t\004\027\024 \r\t\016\r\035\016\033\021\f\016 \r)]TJ /Span<>> BDC ( )Tj EMC (\r\017\007\036 \035\017)Tj 0 Tw (-)Tj 0.246 Tw T* (\027\036\005\027\t\b \f\021\030\031\022\021\031\030 \023\024\027\017\032\ \036\027\027\024\005 \220\b\024\020\036\027\027\024\f\021\017, \r\023\035\ \036\021\026)Tj 0 Tw (-)Tj 0.201 Tw T* (\033\013\017\b\f\016 \r)Tj /Span<>> BDC ( )Tj EMC (\020\035\031\002\024\022\031\033 \023\024\030\006\017\033 \027\026\030\031\ \032\027\024\020\024 \f\235\017\027\022\021\036\030\026. )Tj 0.118 Tw T* (\212\024\023\024\035\027\017\021\036\035\034\027\024\036 \021\030\026\027\ \f\023\036\030\017\027\036\026\035\034\027\024\036 \031\035\034\021\030\026\ \r\031\022\024\r\024\036 )Tj 0.032 Tw T* (\017\f\f\035\036\007\024\r\026\027\017\036 \r\t\023\024\035\027\016\035\024\ \f\034 \f)Tj /Span<>> BDC ( )Tj EMC (\023\030\017\n\036\027\036\027\017\036\n \004\030\036\f\022\024\032)Tj 0 Tw (-)Tj -0.025 Tw T* (\027\024\020\024 \022\024\027\r\036\022\f\027\024\020\024 \007\026\021\004\ \017\022\026 \f)Tj /Span<>> BDC ( )Tj EMC (\004\026\f\021\024\021\024\005 3 \204\206\006 \r)Tj /Span<>> BDC ( )Tj EMC (\023\024\035\024\032\036)Tj 0 Tw (-)Tj T* (\027\017\017 \035\036\032\026 \027\026)Tj /Span<>> BDC ( )Tj EMC (\035\036\r\024\n \002\024\022\031.)Tj -0.01 Tc 0.13 Tw T* (\207\035\026\020\024\007\026\030\016 \024\023\017\f\026\027\027\024\n\031\ \022\024\n\023\035\036\022\f\027\024\n\031 \023\030\024\021\024\022\024\ \035\031 \031\035\034)Tj 0 Tc 0 Tw (-)Tj -0.01 Tc 0.298 Tw T* (\021\030\026\r\031\022\024\r\024\005 \024\006\036\027\022\017 \f\021\030\ \031\022\021\031\030 \026\023\017\030\026\021\036\035\034\027\024\020\024\ \026\023\023\026)Tj 0 Tc 0 Tw (-)Tj -0.01 Tc 0.21 Tw T* [(\030\026\021\026 )0.5(\023\030\016\n\024\005 )0.5(\022\017\001\022\017, )0.5(\n\024\032\027\024 )0.6(\024\023\030\036\007\036\035\017\021\034 )0.5(\022\035\017\027\017\004\036\f\022\017-)]TJ 0.62 Tw T* [(\027\026\004\017\n\t\036 \235\031\027\022\006\017\024\027\026\035\034\027\ \t\036 \017\n\036\027\036\027\017\016 \n\t\001\036\004\027\t\b)-9.9( )]TJ 0.032 Tw T* (\f\021\030\031\022\021\031\030 \024\030\020\026\027\024\r \n\026\035\024\ \020\024 \021\026\026, \024\006\036\027\017\021\034 \027\026\035\017\004\ \017\036 \f\024\023\031\021)Tj 0 Tc 0 Tw (-)Tj -0.01 Tc 0.093 Tw T* (\f\021\r\031\033\013\017\b \026\027\026\021\024\n\024-\235\031\027\022\006\ \017\024\027\026\035\034\027\t\b \017\n\036\027\036\027\017\005 \(\023\030\ \024)Tj 0 Tc 0 Tw (-)Tj -0.01 Tc 0.1 Tw T* (\035\026\002\017\030\024\r\026\027\017\036 \023\036\030\036\007\027\036\005\ \f\021\036\027\022\017 \023\030\016\n\024\005 \022\017\001\022\017 \r)Tj /Span<>> BDC ( )Tj EMC (\023\030\036\007)Tj 0 Tc 0 Tw (-)Tj -0.01 Tc 0.137 Tw T* (\007\r\036\030\017\036 \r\035\026\020\026\035\017\013\026 \017)Tj /Span<>> BDC ( )Tj EMC [(\f\017\n\023\021\024\n \017\027\r\026\020\017\027\026\006\017\017, \r\036\ \035\017\004\017\027\031)-10( )]TJ 0.114 Tw T* (\026\027\024\030\036\022\021\026\035\034\027\024\020\024 \031\020\035\026\ \r)Tj /Span<>> BDC ( )Tj EMC (\023\024\022\024\036, \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\027\026\021\031\032\017\r\026\027\017\017 \017)Tj /Span<>> BDC ( )Tj EMC (\f\024)Tj 0 Tc 0 Tw (-)Tj -0.01 Tc -0.051 Tw T* (\022\030\026\013\036\027\017\017 \n\t\001\006 \023\030\024\n\036\032\027\ \024\f\021\017, \f\n\036\013\036\027\017\036 \f\021\036\027\024\022 \r\035\ \026\020\026)Tj 0 Tc 0 Tw (-)Tj -0.01 Tc 0.09 Tw T* [(\035\017\013\026 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC [(\007\017\f\021\026\035\034\027\024\n )0.5(\027\026\023\030\026\r\035\036\027\017\017, )0.5(\017\f\022\035\033\004\017\021\034 )0.5(\023\024\007\021\036\022\026)]TJ 0 Tc 0 Tw (-)Tj -0.01 Tc T* (\027\017\036 \n\024\004\017 \017)Tj /Span<>> BDC ( )Tj EMC (\017\n\036\030\017\021\034 \031\030\036\021\030\024\r\036\017\022\026\035\ \034\027\t\005 \031\020\024\035, \217\017\f.)Tj /Span<>> BDC ( )Tj EMC (5\).)Tj 0 Tc 1.388 Tw T* (\216\017\030\031\030\020\017\004\036\f\022\026\016 \030\036\022\024\027\f\ \021\030\031\022\006\017\016 \f\235\017\027\022\021\036\030\027\024-\035\ \036)Tj 0 Tw (-)Tj 0.76 Tw T* (\r\026\021\024\030\027\024\020\024 \022\024\n\023\035\036\022\f\026 \r\t\ \023\024\035\027\016\035\026\f\034 \r)Tj /Span<>> BDC ( )Tj EMC (\031\f\035\024\r\017\016\b )Tj 0.099 Tw T* (\211\027\017\r\036\030\f\017\021\036\021\f\022\024\005 \025\035\017\027\017\ \022\017 \204\206\211 \017\n. \204.\200.)Tj /Span<>> BDC ( )Tj EMC (\214\024\n\024\027\024\f\024\r\026 )Tj 0.047 Tw T* (\023\024)Tj /Span<>> BDC ( )Tj EMC (\n\036\021\024\007\017\022\036 \023\035\026\f\021\017\022\017 \r\027\026\ \b\035\036\f\021\273 \r)Tj /Span<>> BDC ( )Tj EMC (\f\024\004\036\021\026\027\017\017 \f)Tj /Span<>> BDC ( )Tj EMC (\035\036\r\026)Tj 0 Tw (-)Tj 0.136 Tw T* (\021\024\030\024\023\035\026\f\021\017\022\024\005 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\007\017\026\020\027\024\f\021\017\030\024\r\026\027\027\024\n \027\026)Tj /Span<>> BDC ( )Tj EMC (\007\024\024\023\036\030\026)Tj 0 Tw (-)Tj -0.025 Tw T* (\006\017\024\027\027\024\n \220\021\026\023\036 \017)Tj /Span<>> BDC ( )Tj EMC (\023\024\007\021\r\036\030\032\007\036\027\027\024\n \017\027\021\030\026\ \024\023\036\030\026\006\017\024\027\027\024 )Tj 0.07 Tw T* [(\023\024\r\030\036\032\007\036\027\017\017 m. lev)-15(a)15(t)17(or ani. \204\036\021\024\007\017\022\026 \023\030\036\007\023\024\035\026\ \020\026\035\026 )]TJ 0.42 Tw T* (\024\f\021\030\024\036 \r\t\007\036\035\036\027\017\036 \022\030\026\036\ \r \007\036\235\036\022\021\026 \023\024\r\030\036\032\007\036\027\027\024\ \020\024 )Tj 0.324 Tw T* (\f\235\017\027\022\021\036\030\027\024\020\024 \022\024\n\023\035\036\022\ \f\026 \027\026)Tj /Span<>> BDC ( )Tj EMC (\007\024\f\021\026\021\024\004\027\024\n \030\026\f\f\021\024\016)Tj 0 Tw (-)Tj 0.33 Tw T* (\027\017\017 \007\035\016 \235\024\030\n\017\030\024\r\026\027\017\016 \027\ \026\b\035\036\f\021\026 \032\017\027\036\f\023\024\f\024\002\027\t\b )Tj 0.274 Tw T* (\n\t\001\036\004\027\t\b \021\022\026\027\036\005 \027\036 \n\036\027\036\ \036 1 \f\n. \217\031\002\006\024\r\026\016 \021\022\026\027\034 )Tj 0.074 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC 1.28 0 Td [(\n\036\f\021\036 )0.5(\021\030\026\r\n\t )0.6(\027\036 )0.5(\017\f\f\036\022\026\035\026\f\034 )0.5(\007\035\016 )0.6(\031\r\036\035\017\004\036\027\017\016 )0.6(\023\035\024)]TJ 0 Tw (-)Tj -0.01 Tw -1.28 -1.218 Td (\013\026\007\017 \f\024\023\024\f\021\026\r\035\036\027\017\016 \022\030\ \026\036\r \f\235\017\027\022\021\036\030\026 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\031\001\017\r\026\027\017\017. )Tj 0.004 Tw T* (\205\017\022\f\026\006\017\016 \f\235\024\030\n\017\030\024\r\026\027\027\ \t\b \n\t\001\036\004\027\024-\235\017\002\030\024\027\t\b \035\024)Tj 0 Tw (-)Tj -0.014 Tw T* [(\f\022\031\021\024\r \023\030\024\017\r\024\007\017\035\026\f\034 \031\ \035\024\r\t\n\017 )0.5(\215-\024\002\030\026\027\t\n\017 \001\r\026\n\017 )]TJ 0.198 Tw T* [(V)-15(icr)-24(yl 3\2260)]TJ /Span<>> BDC ( )Tj EMC (\017\035\017 2\2260)Tj /Span<>> BDC ( )Tj EMC (\023\024)Tj /Span<>> BDC ( )Tj EMC (\021\017\023\031 \253\001\r\026-\023\026\035\034\021\024\273)Tj /Span<>> BDC ( )Tj EMC (\227 \r\027\026\b)Tj 0 Tw (-)Tj 0.074 Tw T* (\035\201\f\021. \202\027\021\017\002\017\024\021\017\022\024\023\030\024\ \235\017\035\026\022\021\017\022\026 \023\030\024\r\024\007\017\035\026\f\ \034 \031)Tj /Span<>> BDC ( )Tj EMC (\r\f\036\b )Tj 0.541 Tw T* (\023\026\006\017\036\027\021\024\r. \200\f\036 \r\n\036\001\026\021\036\035\ \034\f\021\r\026 \002\t\035\017 \r\t\023\024\035\027\036\027\t )Tj 0 Tw T* (\b\017\030\031\030\020\024\n-\022\024\035\024\023\030\024\022\021\024\035\ \024\020\024\n.)Tj 0.315 Tw T* [(\224\235\235\036\022\021\017\r\027\024\f\021\034 )0.5(\b\017\030\031\030\020\017\004\036\f\022\024\020\024 \035\036\004\036\027\ \017\016 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC (\026\r\017\f\017)Tj 0 Tw (-)Tj 0.33 Tw T* (\n\024\f\021\017 \024\021 \021\017\023\026 \023\030\036\007\024\023\036\030\ \026\006\017\024\027\027\t\b \220\b\024\020\030\026\235\017\004\036\f\022\ \017\b )Tj ET q 70.866 535.541 221.102 94.322 re W n q /GS0 gs 221.1023475 0 0 94.346609 70.8661351 535.5168011 cm /Im0 Do Q Q BT 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf -0.04 Tw 9 0 0 9 70.8661 524.7413 Tm [(\022\t\217\210\b\002\220 )0.6(3.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf [( )0.5(\230\004\n\202\032\026\003\003\026 )0.6(2D )0.6(\230\212\214\221\215, )0.6(\033\032\n\030\n\023\022\021\n\031 )0.6(\t\031\006\031\021\025\031. )0.6(\207\024\032\n)]TJ 0 Tw (-)Tj -0.032 Tw 0 -1.2 TD (\031\021\025\031 \026\021\026\023\022\021\n\202\n \013\026\021\026\023\026\ . 1)Tj /Span<>> BDC ( )Tj EMC (\227 \t\024\031\021\013\026 \021\025\204\021\031\026\003\033\205\023\002\ \032\021\n\202\n \n\024)Tj 0 Tw (-)Tj 0.118 Tw T* (\030\031\023\026 \033\032\002\003\n\017 \013\025\001\013\025, 2)Tj /Span<>> BDC ( )Tj EMC (\227 \027\021\205\024\032\031\021\021\025\017 \t\f\025\021\013\024\031\032\ , 3)Tj /Span<>> BDC ( )Tj EMC (\227 \021\026)Tj 0 Tw (-)Tj 0.275 Tw T* (\032\205\204\021\020\017 \t\f\025\021\013\024\031\032, 4)Tj /Span<>> BDC ( )Tj EMC (\227 \r\033\025\024\031\023\025\017 \025)Tj /Span<>> BDC ( )Tj EMC (\033\n\030\r\033\025\024\031\023\025\026\023\022\021\026\002 )Tj 0.01 Tw 0 -1.2 TD (\027\020\t\024\025\023\013\026, 5)Tj /Span<>> BDC ( )Tj EMC (\227 \021\n\204\013\026/\033\205\006\n\013 m. levator ani, 6)Tj /Span<>> BDC ( )Tj EMC (\227 \033\n\030\013\n\204\021\026\002 )Tj 0 Tw 0 -1.2 TD (\013\023\031\024\006\026\024\013\026)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0.081 Tw 0 -1.2 TD [(F)-16(igure 3.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf [( 2D ER)27(US sonog)14(ram, longitudinal section. The struc)]TJ 0 Tw (-)Tj 0.098 Tw 0 -1.2 TD (ture of the anal canal. 1)Tj /Span<>> BDC ( )Tj EMC [(\227 w)13(all of the low)12.1(er am)16(pulla of the )]TJ 0.106 Tw T* (rectum, 2)Tj /Span<>> BDC ( )Tj EMC [(\227 inter)-13.9(nal sphincter)61(, 3)]TJ /Span<>> BDC ( )Tj EMC [(\227 e)-15(xter)-13.9(nal sphincter)61(, 4)]TJ /Span<>> BDC ( )Tj EMC (\227 )Tj 0.004 Tw 0 -1.2 TD (epithelium and subepithelial lining, 5)Tj /Span<>> BDC ( )Tj EMC [(\227 leg/bundle m. lev)16(ator )]TJ 0 Tw 0 -1.2 TD (ani, 6)Tj /Span<>> BDC ( )Tj EMC (\227 subcutaneous tissue)Tj ET q 70.866 198.196 221.102 208.041 re W n q /GS0 gs 221.1023475 0 0 208.1386888 70.8661504 198.0986736 cm /Im1 Do Q Q BT 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0.183 Tw 9 0 0 9 70.8661 187.3959 Tm (\022\t\217\210\b\002\220 4.)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf ( \230\004\n\202\032\026\003\003\026 3D \230\212\214\221\215, \013\n\003\005\ \025\021\025\032\n\027\026\021\021\020\031 \t\031\006\031)Tj 0 Tw (-)Tj 0.241 Tw T* (\021\025\002 \(\026\013\t\025\026\023\022\021\026\002 \025)Tj /Span<>> BDC ( )Tj EMC (\t\026\202\025\024\024\026\023\022\021\026\002 \033\023\n\t\013\n\t\024\022\ \). \207\024\032\n\031\021\025\031 )Tj 0.048 Tw T* (\026\021\026\023\022\021\n\202\n \013\026\021\026\023\026. 1)Tj /Span<>> BDC ( )Tj EMC (\227 \t\024\031\021\013\026 \021\025\204\021\031\026\003\033\205\023\002\ \032\021\n\202\n \n\024\030\031\023\026 )Tj 0.037 Tw T* (\033\032\002\003\n\017 \013\025\001\013\025, 2)Tj /Span<>> BDC ( )Tj EMC (\227 \027\021\205\024\032\031\021\021\025\017 \t\f\025\021\013\024\031\032\ , 3)Tj /Span<>> BDC ( )Tj EMC (\227 \021\026\032\205\204\021\020\017 )Tj 0.295 Tw T* [(\t\f\025\021\013\024\031\032, )0.5(4)]TJ /Span<>> BDC ( )Tj EMC [(\227 \r\033\025\024\031\023\025\017-\033\n\030\r\033\025\024\031\023\025\ \026\023\022\021\026\002 )0.6(\027\020\t\024\025\023\013\026, )]TJ -0.03 Tw T* (5)Tj /Span<>> BDC ( )Tj EMC (\227 \021\n\204\013\026/\033\205\006\n\013 m. levator ani, 6)Tj /Span<>> BDC ( )Tj EMC (\227 \033\n\030\013\n\204\021\026\002 \013\023\031\024\006\026\024\013\026\ )Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0.175 Tw T* [(F)-16(igure 4.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf [( 3D ER)27(US echog)14.1(ram, combined sections \(axial and )]TJ -0.027 Tw T* (sagittal plane\). The structure of the anal canal. 1)Tj /Span<>> BDC ( )Tj EMC [(\227 w)13(all of the )]TJ 0.071 Tw T* [(low)12(er am)16.1(pulla of the rectum, 2)]TJ /Span<>> BDC ( )Tj EMC [(\227 inter)-13.9(nal sphincter)61(, 3)]TJ /Span<>> BDC ( )Tj EMC [(\227 e)-14.9(x)]TJ 0 Tw (-)Tj 0.001 Tw T* [(ter)-14(nal sphincter)61(, 4)]TJ /Span<>> BDC ( )Tj EMC (\227 epithelium-subepithelial lining, 5)Tj /Span<>> BDC ( )Tj EMC (\227 leg/)Tj 0 Tw T* [(bundle m. lev)16.1(ator ani, 6)]TJ /Span<>> BDC ( )Tj EMC (\227 subcutaneous tissue)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\033\030\031\030\213\b)-20.9(\035\231\213\233\t \021\032)50(\b)42(\032\231\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj -51.938 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 23, \023\0221)69(, 202)69(4)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 23, \023\0221)69(, 202)69(4)]TJ /T1_4 1 Tf 25 0 0 25 28.2525 56.0378 Tm (74)Tj ET endstream endobj 1857 0 obj <>stream Adobed     '$''''$25552;;;;;;;;;;   ####''',,,   ####''',,,   ####''',,,""  !1AQ"aq2B#R3E $%&'()*456789:CDFGHIJSTUVWXYZbcdefghijrstuvwxyz!1A"Qaq2BRr#3 $%&'()*456789:CDEFGHIJSTUVWXYZbcdefghijstuvwxyz?d];24۬0i!0ީ]W?OdG\@iWZȉƌ"U{֙ M3WHkG%V+ sK79 )@x;Na5Kw(%ƒt$z_VGB|-oFP#\_'T" Qn->{[q,:#RL;I700;UBn:ZoXf F9O&u/Q>Y.KG0SxċJrq{1o}gM|ﻓ;yQqܳtЍ|k[`NWEdC.qѪW! [a{Yh1rmZxHqHZ=u7 f}Rmo~#6ّKsv XvgfO{4EC0S C{+x]Th0sGDPߟ' +=ÎTqy3;8\zﺲ(}9gO;`+I/]a9GLH[LKŬ% ҃S whsQ,|%w^`✵_gO3̱8$o_xz}Q%T=>-;k{mV5f.KF7(ѬE6x\:|GH[`SԊ''η2cAt=QdIqZ6vZxi7GŠ(E4Z-in4@m~f2D9h#,#+B4zx>Z]]2qǿU":K\`F ic!ْhW%*ݯڴqaq#ćcLB*|y'9e}ߛsf fܶV }Β]Nd۪4w0WƓ6$kkIVkԿv˕ ϤYk>GkÊGzHwo\+xexa]+X4 t}\#sbZz}J4O:@QT|O 0r\G+¡í.{q|H44͗J^+ƯHܳ ]ovd*CFqI@%vg5[?!)pjܕx '&q$ vp z8\VK0h:|[hQzxRm@wCE.WoOK.4#_ 7:eqolRۉSќdFi_f'&eݘ/-7^!elgP|ppN̂*oD[;i Hi?ҴH>:0:;BR;@&V6:0SHJԏD8K l5|!/WٔF|=_: f 8 i$GOn';۝K2"g>B%“dKPoֵ| W_yh]oz 8i9'}Fx*~"+ӊ>5yܝ'Hw:^4x۬f7A#F?x[+k]/8^W!myٯ[r%ͬce_ypawZ~/HӕhqK:YLd :۔hהY'f.,egĕb|#^$a+>O/;P|_^o^c'iH,Ҡ.r]א9z W{? J6~|'RAS/_+)X>~h]vAB+l7H]ѯeO~ 2)Tѹ&~ Bg CQ-M{rZo? ͭ!m7HR;O|vis7^ j_|#_omfW#)0t;8{^<R[ubwKDhiGQ;DtZBs]i4r<;vž=U2!\k]3)L^ۙsI%#1YAtUUJwIKʳ6cYRD5//9e63~ s\}Y}uS*X#󾪗F>N@jƹ&zj39io267Eh79}?{] Y5Ѓv\|LWu7|fjJǸ Љ0I\D&AaUq @-.i"5Syu1b&]Cڃoyv<ĕFUZr~^%:jQW7 *cݧ`Qu93\$fD:%TQ&g4sdm(ѪqXK9+dR4KJyNSƣ7IbCfx|&Rf/EY=IRd ìdTdsSGil@V)h m 摨UJ%>g ?splnRYxןWʍ)N'3IŜe7uKz`;u*` geqe+=)KKDqsh׮|IC^N?NgTU<2Zzcī 4H.m[BΛWLox8I^ @Sӯ+]hdhyqnOHߺc.2LsNQo S묲w(==bR5W*4t|T^ךmZU)U1p`آFi3~|Hѭ$|ҊW]‚UtD}7\pڛZ!sPG';ow iq4Du̪\눁3HѮWi/gυ<X$-qZ8E:S^-x|I(LPc3#4Im9qHHh7QPH־<#OEЈ/ ^76qq;{A=qXև8JaD၅lgN6=[V&0EEC94rF}f8Pz^N# ﾩ>xqkuK4>K$8G#a"^?[y^{$HePSVۤ +0cd*x]G9hs^Z1&f=$}?'u.'||Wi0dԾC߮aŜc'qfKplpcrV$C>7TʉcEk>'^RwhO;k˓M"E4Qs|jTR!O(s.êgMm9՗Up=maEP0QNO0L~}:?}Ⓦ# ]t.<o=p#1NjQ$f=>eNgK/({' "@#oyφ(B1p${gZEt-ۢ[J؝kU|% GUF沗MuX>SË̝L8d)xO]mto9pΉq,RΏJyxL~ene'Ϩp|FrxSxNxzx"箭r*y[VyèRn[̝4eikU:n(9\֛#FoޝZ=m6pbזָ-Hռ/g¼G!&ȕ82|OP80N3;n|<2iHUfqwLŒ QRg5yۋôpJ7/q8tOnzEG$P:3 XKqtij}kr;6[ղ|-Jpooq_{8C=d>qpQ=="J֭pQ܌PY;TZ*\lZ[i; fhXa2_#F;|=,C#j>RToG?N߇^Gq*U AV7փ ߵNd.{ Zui랃gFz4pEwr H5Ʌ j`o7BBqq$L^t{|FS9 5޵)&!5GN8v%v4f;5%>Sj^)DbGҬ*2m0Tz=]7+4_mZ|1W;jS~3f[?'hTs\;x l̨ڊ۫WČ^ pBrIW;!+rϨ5WDwÀCoBҠ4*[P #-*U1ᛁ;SP1ELח$a pHdC)9uPkx\D˺^w蹸r|*U?LcT9cHW2:<ߥփa hFg uibq=vurdtף][uJusW spr:Hg!KMq#q6dh1z5j%H[L|LC2%pmpC(DojlvGF~M,uTu1O 5&]- GE%q ѣ垎)ąXq=ڻaW€O+"N}CfQ'F}>:z|8E pCMY$OIZ%VKŲZj.Fz0qN`1yn8oL]0W4._p'͝ݚp`˅'d{GY>P8@7=Md,ԌpڥO4k W(+{ o1^Iq3c{G#0dT_b3)Wؽ6CYFyecAs2Ey4iB)OضǝjXÏ.0.]m*Q)ze[kd9:za(oxTǑ1Yx ϳц>jg1FF|LFoxV4bcVC^֢ή+SUx:edWfQը1<o  kSuޜ"+t&l55]ĒmԾ%x(NN;w.5t˄2zs 1 &ϿW>|vqr'>K1Hw op45)s\C\+>/i.a-;On~b efWTtKq3uAJ\o\9X)Um^ SWfO? Ĺ IN8}K>O_1/TN1$] }f>9_#bJ zq{>cbxp" >&bEtw6܂ѥJ8mMpc%l&n/^#ĸ.iȶUCzDs_ݲ>mx|>{en=Pn\YIp󗪻te;4[IH Gv<b;꿺(us陆Ъ$O ,xS~hx{J;K?{5#3~"',\^78{. :,X!8>o:aMk?-7ß0>7K]ňca78 P%p;uc|Q%K]$!츱g)2HWj 8lx\^$JR&-g^;5/KtSۨQGkO Sռj "Ivj^`ڠ4Yt}yqo* P$_ǿւP tuDW&p M b96 kK /ʍmcB\2&/f{N8_sa)pϰ~'ϴSoͭ|խ|^d\xpĵzo1-&2 ]$țŋ 1e]4kg\({H(PS8DxP9of?Q>g#89Σ88|n,xbFezzA̩&zQ: A{nnv.l#FL~R^vgc kqr\|<Q^#s|K$lc mX取lC3)K&ZzW|&vArx,p(Fs i .ZmFf|g0{QSO4n5x>'MXqAҏ<>8H 7ir56|eOKq|k*v %q`~4众dpz?WYNp8LxRO]Z A9 a_0KNBX;|{=uiǸ:pRizEVgUʖX$#Fi9ޘx|UQmߓT=18W'{< ~~<81Rg0}ڕͦ4'Kf2YN!Cpº Nhb8Hq#%,78ҵ?|xcli믛sץ9DzY̑+r 싗r>T _q 4}2%go 4%"ɉVǸXQ~CSt*gɚ.&9uUΰ4\-#p L vPW𾳼>U믯KjA~S%a6t3\ NR|'jr͍urpd^sD8_IJ1X Z.<YćL23>V)aD}:sG^>le8UETMZ2wAC`Z]v4pHPC!Zr¿$,RV.Lt:l XKxpz_Ke]m}6O@v~ qyI ='M&G/a8'/ D>Y28I(Z7ΩOv!GJcŃ)\h.0?^-o9 ,cèW4Z|pXe^V{jg6,lL\IQ sˣ} e ,%LO^o/JWJRza2#Md+7֯qJΘUF*^_FP%\%=u.acZF0b4Km3kT+ \A PL AKD"ZqF#+jU^T~}b|J0Tœ(oOnr%Fr8f^X9sFl8uĹ $їs#`R xOEуjbG5h]V:g{h. 4_/7(FLg~+>X2f%y^$V|:N8ss8ϦؑYeq'ÌF]Q|'sMTvEJKh06`")耍ˍLtͦ L 7zSxfʊ;ky 7;a]F;^$`lι k`,pF.i$Obz{Q!̣#(X̧Z5zx.Th8<Bq-`A+zI%6ZJI(ܗi !坽=IF:=BcsADUhV`bAJ4i?j>],~OT\l}[C2m^qzx :u^`C`4k>4c CZ& q cWÍx'ݭM)Y>zՃUĈ]g8N ׳xʏ !Ϧ ND=$Ϧ 焏TU; O$u-jH$_Ԉ_asQpq%Up2R@/FnOv_-,ٱ]]ht=w.1}VweifhLewM s0JݶTM6-G:n6yX_Akԏ/yՇ3r<(Y5?G\23[H Ej\I#UqeU*\S/dr'%^wYE#URN@12EGius_Os@=(S\_lj[Is^bTNs뀔A(p9=LJQ!(>mGⴾ~D|BW9Ę:'/N|%+Ư8e3G8[\A"mC| _i϶U \8C-G4֍P!{HB~))OK늩0.8BY}|/:qԢx݌xg^:H9֠֐]1ȺZq ݛ\*"XK6F˥ON<0Mkv?闇ru^YW[8!0}ۨ/?.%8Fܪ>ʂ!C08Yj@aep99/|ܺLU i xo_O;+/o31HGbtȑ(P6ٜNv$dGWͩzۉIag;&psd@t룅2nQ߄OJ$XÈB%6s_c>DN[/Vޚ㧷 ˆG[Jk#Y:Wo I ^HijЧQP9D[lZeZ؂a͎#EOn౟//NQ[_xɻ;ֶgƌ 'RI.Qd߰3ruE]%~$)io8iq1{-X\NmN # hܐE)ȼ8!=$~7~'$I/<5hޤͮ>|>$HōW39\m:6[Fk8=$iu[-!AP5s8sG]dx%. }RW7ԸZ @*q$lg@Z|k76@c0YDKp5i警]Lb&H &wjeGR#+?]^9,F vSUhĶZ0_dBԨH"H(jנh;B՘pd4kg3IUuo^~?._Gߺr<-Lbhu}հ丱)ľed|?zO]N42\AHk0 q̒MAR9@;'2NQXxqω)FQǞ+đI&X*1GVWgp}D2^"B&z{O {wqkAY.̓9ZU77teԨ &jKR)=|8(K^sk~ 8| c$ |#qE/2_>o^w%>K GkO"_1f(3J%pEӌVZ\}Q!l B18P}6"6r ƎI~76L$>UN o)P6v3r)Ky~OKǟTHRmr˕cFUd񷶳(ԛ{4xp'> W:Czk%DnVRNH(ӽuW':Nꕦv:\8!$+_Botsdžqaÿ Fػsk߭)zyY%wqܷuپpQэ jJNJR7g {eKuw4``t@ֵ"Ă_B \7ėS|U>ߓ}:8sV<L8dnO zg60$^x6ߏG- k{$'5}g"Qg֮7vOCw^=KDk`%% ѫS paYuJ{pdBUOVC]O1 8$Z_~)NV2CRBw{'5G2K:[޵w帼P#קzS]FPnp-(`ڪ /PGrTO I[/|W@Nֽ;4hSP7luU]r#F|'yJ=RHn[n'-}wR5xsNc.12}><^TbG5H;z]L'j54ƴDEE53$XHdhB\NrLcnj8䔴_ޫ#9ID]|uޏ9/MX>}Me_p$\I2O:дC:  9~86u-:[}zrs=P4OJnW<^n^||J[G?{u> gN%1S.𾳼Hue6|4fė[%˔K'Uv-ls) \8"b˨ÏвcVX)bh3GjWQlDɎҭM뻝jӨLJ/|rQ>4ZLrz[ ľ cpx:K{JUh}G1s3evsNZ kF]KE.Ni MdI֯o5v,u‚L2y/.s iK>[r|<|HY)!ϯmcNQp1 ȸ)dk3.y~a+*t^kœ}xcgdTdINkU"D%}  V:B_<?[@V-l<)r-5.>s@Oԩ+׏>$a%MD=鍯S?g+S}5Qh q`r콮eGC`QWq t (ӽwR.(!.ڪIq o? NŽ=朢Gs^ !F^Ѭ=6n :(j?&k=Sj1gp&%?R)B{A:#>ZVqq%;i&Pu"1+kyN_VP!NiN>#*Wyp8džWZԮkNєx0~zmԔah`x`7"nV@hcȧZmOEy ETTGONypx' ՛yy˂3HOh1ׁxIw9uhPfv֍wCyDTiM vP0;'#Z矄1!f|b2'.vߕn9 É ROrEk\3 J2+*o5Z& mSԩ=P/<,ioUg&kHîѮrZޠ-Y' $Af>8|~qP"/Zk v:>49{쨼l6- M/v'25xIT~\hp.e0Ďş5\A8nqWjdC]IƇ?0 ¾C\/P("Zbѭ5\,BB\Xm{ģu>/| #3#ֆkk|%̠tF#k>vV:// gh0@8m%ȷt46A4b;ͨ\EG$qNhӭgJpB9~gVYou/b/r/߮L1(N GzgS2mڧS!A֢Ul6uK(4VkCycČ$zbe(fm!S(0a}|Z>4:쌣)5kjUc M*19f -Kq.~ѲtcoG6SĬ.Y\0(NK)1vΊN*\08ss$QVeZ1S|~Cd? r$Mkt _ˆuίʊu臱#YTo'xRCZ++6.6az t}$3a/ܥR2HB4k#ÄCoK9~T> T8)7^/vqg> c GQ ^KOI5J}joO2!sZMLO ʰh[NԨ@LtQZw^<9ƸDžğI |ڔx<V."Aǻx "8|.)̛Ϯ\?Rc0,H^.֎n%)4u4&6HHRɨ QR18Hhח~Z=߃}igx G=t6&~{ܷ3lpHl9^c cXڝI()^Gۡh5)Ck-BN[I.*b˦*U7ӝAAP5 JAL8VnG<xϋ9dp}g q929Ip8\.HIDxMc^+σCˁX/I]DiԬXLkj 5IJvse'6KYy>@BH~HV^q#8c *\HIp~>Z8%C\Ѱ6ʌ.6*fLAq u6I:Ihׯ|pPE: "aNGI2P $z[#渱eMuw<¼HN<bnwm4$c1j i&[ :4 H)LnWzQL:/\T4Ň$leYKk%Ds}S"\kTFo;*|D FOG.pri>}&Sie^R)UܐLUдzs672FHѪx\f<8=~Mmo!g.ϙFSQr;x|>S凚2'ÕRGwӿѪ=e t $X=]FYŴŮUʔYRNt{iT^ @-3x㌒Zz67ѯoeӋip/ֿ~ 3.Yﻮ{˃yn'.q>|D6O-[N8pHNJU޴4FPV|MJ@kpEhnsZ5wMjoY$(jK!߳J,{ݗ][Wˉ.Vxf:f~W~CrgֱV^{qK&D^츼.Z07&neUᵜ"{t8.-mȒڠFyD[?l9+|K\g> 8͸dIgn#>g\C. H\.7U$/`wq79HXCC&uJjRij=IdoU]S} ,}ҬEjRuG9,N;[˝!Ƅ <;#щ1B0mkE;j? Jq(Z$-J'# JPb9YXI(>(,k7pÉ' }ϜkښzXwbEy54IP!&_NZA0 T^ t׭MVik-!FhFJXE[ڃAA/Mɓg^nV3ǎFy'$jV(5r]x>_\I=qA;׹w巉%)@8_:;987|.)WPSmU湎QgN.FcE $4{usR[rͽD[bOEiײ-q(sd`Tdt]j>T/7œbz+7.Wx‡ċ/Z9Rn .$i{XmjoU%]Q5֜G3H|MF"YN$$p~7zkƗf(Ǫ+ŜqwڵG&k14 FӐD)DTkE| -ksn?I{8TXۘe5 .'-37!.MS[>eDGZ_Kgϋ'z.mkzw-7RPI<@kV78K8 ^*`F={\|"<~m(_K6=DWg^ yp\.#(Rɍz ^ 2pJgzҌbLmĹ "&vZW\e.#{:|\3fx}~^W %3_ /t%߲Ձ<030<|$xo/=czXr(2br=FlʫΗÔxx\^cD{x.u۞Λ+]v5 ifD 5=e 1ѷOwףr%>/j=WF1.zק^ i#9Gm^QwO*|$FgRi{ah%aWJҴ}>d9e795_r8(BOLl;Mf&W1_>|#C #r5ח91e3åzXܾ]y?<0=p$5@=Thu<ӪM0C7X [#7oJ.<Md6帾߁4<^$(|ˡ)O%׽p!38D{W~s-G8T+m5Q~O~ ÅCǯ$ޠVn^|^,bJXvA*ZE ;P@-zDxl۾z payRq8)P*WhËovy!@o z^qi+T_'G 20b,9ڑP0"KĖ-hY1js L4\jPÌ#\ IqF9߃Io]owx'Ŕc*eVċ^!d8Kz/C7ruqPlizE1mGfz{U׺· ^ԛ3Ni,kʅtb46NLU%S8Pҡޜ>2qğPngy.*&b>]GXJP8e)xZkلƽr$c'?oOzm66u“Epc''pL–+\'CqCY/=kR2D)-ʞ1a#I#/n^_Y_9nk_kB. (}-{*-_IN4"F4\LpǸ*@^ upY2nW/]o7˒m-|ח|||c  )Zf]*m&.U4,"h?ʶaFysp8R(|>  $Smm>C';Gݠ[NI q39mBDj: Uoy 8&_CO(5|z֘|锡DŽcbl)myoėW/mBncŒh@?3:OF;^6AZj ߶Vr hp/#jJX@h1ȍxyYܥ Dc9?8ܨI>(e(Dϙי0q8"dmz/j}*{fsu6;U.ް^d*n7i4kqexx./m'mn/8ϚNs9nzf:22ǷR!%l.e'9"89^bFqCGF9'GRV3H7.WCašp:t>S2s=D:${w^;yN,}2RhƲt#Haרf@q*MJrC1ugF[L A$qt5`1t#V/rxx./ $:JDh^׻GAJ=R}K})V2`C>BBQ#:$!Ѵ^f k% 8@DŽ5|O}Ss[{ÈTJKgjv=-i|a ;KbWh4H7R7I^` 4jgN7<:׉]yI`3^]ݷje կ&Փx2x `=iPq4%E=@M0.?v_אq"pB;Z5Up.Ae\XGYBscăZņ+ݩrW=7Õd5\zf[9kP'.H$:ծcKCs~ #2x~ 1C{: q!(qm;hU쁠.>BSxR'bttd VSYx x#&_z~gVG^ O]=]u*i$X5*sH&l dX7`#Z4isJ<Ə_xs+6򼦺S)rcFxj[,ɨHQf5.H,3t'Ak]HZKb`p.q4`JQq%x5KzSb+ٯ~×/' mll91ˑ_!K~}>HφGᥨb>NԺfi:icέCqA  GpL8 F#h"ӻ:!gN,8<Ìb{kO*(ޫ>|!8,d0>]z L#mn@y 8Pr`K]/o:.y:_ܽͣ*ў*e{@IT% FeSfnUA F3Y>8<“%ϖa3>K5( vSPp#h*g./^O Gs>=pSKԝ6kOx|oe838.(ӟ׉Ã._N&Pp|fNtT*A}.:1CBu}BZK$1&Vuwb%5 ܼ1'> 1g^)~yp|w87է뜸O$sM]w?c~#ŋrM]\gLӯuq>[qPXKk@iLFLM!DɲPs4V9 VqKFSdf¾O3䘜/sp mXc^ -#./@|XveCpI[ѴSџA&H&Q:,/gQqi^+e闋Ψ}<)>S}R>xjYOCuNjǡ z9XK> Kŧc{AA ,sLdAnW3=K,2uiSQ^ 78N}Uncox|n_˥. sN 9V|Y^·ڭ_UK=שcƔV>ML%ΛD Z2v h׃}f\fIqħ?|/Ŝ^d)u@%^N8VHoeջx4M ATǠ37xFq~幎CK<'<=BlvuҜ&(LMb縟qU.vd3ڧO pAFx'%%OpWq8lr- O~y^7amOj 1^qkhL)]DNÉ4Y&ևL_F._rix O Z? rx%g[ ѣ^1+mdž7]WSj&tq;jGj T|W,{8ѵpxycm63RSniQ)uG@ 5=SQ":kh.?ץ26#X>COŜ7z)/[/ZM.CK) NhnUcӓ@Z镹Qe5 lpFk\"O' vCIJ\>7EpIB]^~owA$8$$`FΫ}l C&r uï~?i48\텩703BysxKxәDQ4j|V`=5GO0צ||~x0922V~n2Wq{ipmESR OMS1XL()˒RjFy8]`UOgȮ1HNwC^oW+N$tWk߁qm 9Y6G{c۾BHITEΒWT~,5Å p%bT׳Hpe9i|˕5<&buLm-3 x0djFb%ߒv Ϧs0T1uE_XFÁ6Ǯk 2u t벉gQFr-.^\IΧ9E`G.I@1BBz]h9Cq#>,.1YgFTcg08 3q)6F7)caB$92\'>Thy|Zy=;V\yKfVDW^-~É"*_WRMis|~?|<&6m}|_(ު]>m!:^@sΐX adMWp$JSp\55|_G uN흫[~).qˬyVn[%rm#Ǖ5K(pxWpRzjUgNjpd ko9_?Kw|r_JR.'PQ;z|(ռ|8k#˧\W\sF^_1Vqc7\3R.v+t?Dsj9 ѬJQx=pxdo=ﮗ1>\QE0r?>>2t1"Xk5kG.փχP-6qBjn3G GzK)֘Fz#B=D1(R ƽGŏWk\}ή$_zy()d;bI;Y5ڱ%ӥQ<Ë+d\ˏ)p9' ̎eӟ,|rCŸNcj(9HLѯ௬r3帼YO۷Č^%ϑÕJ36lp:V=>-7ض#WS 8);O#F_!9׺H~j~ q='ʍ+n \~Zqz^k>y߄o<*F;PD(#FKӨ.5$IfM=ˑDU.4{tňvFˋ@)v#qbHXx|K:yW=R+S^GE8]%wPYvFwyd ^o= #Œ: +A9{3'3?rL{69gem&ַY.iN#Dh L (:rkxt3\fN=\. N<ZSLKrc>jQ!={ Yk| r FRu=Ru |3pXÚcm\or|2Gq8#^ԮۅJe!3rIbI%_湟m8XpӆF<[ 1..$4bq$'}{20r:u4ۭo#>x\.(-vuQ J':L d^G-WK,moKɯw 9Oi;qQ YR1KP#e^:#xH f %tZ^+cUQzˆ1*!s:{ŻZh2kݠq\$hWzlEϞËW-7N'Q~U&/MF۸qxo+:pn!)N렌ڐFNT{\2+b^DM|{Jo- J;BB~͜;.ayko+ǖG\eJV9V2^}r(ѥFۻZM_ӧ,Q:jAp 褍H2P3g;:r1k\ x(6c;z}8*U|#t2"}Ԍ:3s]d(.6Fr/+aFQ<~C?$: @{`ɨǕsG^Nau{3ph_9x"Y LE z+1Ъ0v#F!ŏOʋa%n`ב|KV*oғ֎{Mo][Sc澵ܼJpwf^YZ J,ydʓF-xVAϷI5/&|ă>,8b#]#\)qSu;a^?œ5˲ Rw~?>C~ /&Q1@mlJfS\x-NtI;[?p:S\E.˃x}],pH%\\_wwC^湳N> ܮ{APR8ߢ#jsFtq!.\^VȼnpQi)/jQGQ^}e9m)e&Cmi#nȮ f1-05ɕtBA5s+!x 2mߝ|w'9?3q2\\)7@.q|Ŕ9]8z~d^2TadR0XW[SKcbܷ:[6`(ѯ#C8ӛB 곚׍|k\&< AK.^O9N+FITG}z X˅+,RX+; jE_q.{Mçz2;4k9'<ħK/T"9p<2m^ |kŌFHCYjѭĄ6@mĢ}=}/phxΩ=%zT v׋_֛c|)0.!+G׹6~]tNHŇӗ0^]qAk77Ǘ8,Ap0ѭB= :S32^z\/THc}[[˗#Fxtԋէ:r`ѧ8 FSE^qfjNwFy^\ŠǽI?o7xc}F㫸if`?(]55"#Fc_~y:q 5*ö@*z]eij ;zpm6:d)>C3ὟOՆx\4DIZ؀HFr\t~w:x1xpUPWF.48KwMAy~|.fा >Fw'䰷cEi1k?}qfQ۩8} 6~ˡr4hJW>~iEYZE#^In4FS.tF{绬<~IxgFM]zJ]ԣ u'؁J4k//.R{jY zc{z 0:ˑV]f5ݶƫxGF6ֈ5b!Lxc!X_=QŜ8QxoIoՃ>7EEIi rFNf幩ē)FRâ2\yӶǗ:LWXpKFH{2aMJqX% `֍ƌ{P~i{?x'ʺ>j30}A "+Ge3r<`(+"4ks>Ri|: (c#hN2]>xgo6zc2rF:D7U=5_1ע1ugw:SⲉƕlX{Nr\9I%IE% vxXBIE s:hѫύˋe(Ktב'8޵O.zΝoו]|>7EjBgRwdR9:-uFrܼO2`̌ǘ[z}HXio'gY9aB1ގ'Nk\HxHvn\s#F9^'1VTWY\gbRꋝïwMcKR[TCp fmcm/⏲M5Jn]i=5Iy3Fy<'|:${ oW<1xpi{2K~^$~X8( 5vFex=S?9px;*KETק,zzy)\XxҖd#xgͭ9{ _*nǑ.\@ ]7Ip)e^zrѨbԾm(}5.LYA,zI{2\61#Z'n$_kW7 <% 4j}'ݍU>7CI^CyAc)vq _Ը=]6\OTbKs+ݩJe6f ѣUxuvpdEVwmhP}Sxb%5# \KFWFbypb4wՑl/z1q82x1qz8ě(DmJn3 FpxߊuwAc_~Eԁ[[ֈ%$o\2\Ar4j3$|'ʲ"R)۩ZvkaM (Ѭ#/ضu|"G6RwJ3Nйѣ g&)_Crh;cFC-N82AFyY"q<8J^lǖd|W8;\O`-T5#FT0}Mb/9u6۶"Xٯ?~B}>(60m3^3` ֻ{W \|#Yyk5ψˮ+gw;ۭo|BS IǗQuWE^[u=]2fֶH< (FFssxnhb=6Vr|9"ES1Fi^^z}KU]+^? N<)]Į}j33%auFz p^ᑋԲs: ïw֪+xlںp*P+'o NY.GE52qxsZ1-t-D'gc$Yh.`ĸ5a9#)Nxoxo9*Q}_/]z${Wρ*3: 7%Jze招(ZyR#F<>r%*ϑtV|~s\xxƚ_Vɇ^^CQ!5ɪ"u AvyZJc4Hj8X9HO%pyy*־A8^:vqyq8.g%} zPaUN\K0c7P*Y%pqW\.Fj80 v'Y6X`}X1FQNR6m[f7Ly@QJv(Ѭg##dܧ;㒛Nџc^ϙ^w38R#(w+@ȰLִ%v ?dqFÜa9J$3k3aG[Kym'` TҗX1)ӈF}BKJRI(h#Fpg6]ݭ0pQ(uOWSƴ5] Y6#Fq kԋ72s3D|%:qDT#szUȐJFhSc>TԦx'O\ȋ@FYtc[.8HL/x^:Uˎk[kOUp[=[\r{7]}_5ڗ55NldmƎ'ܠGmeȜFJ[vP|ߩtda(QUK#,oyn8B,0?F亣R>uBQFNPRdKO]J\0Zt&:[>`+(Ѫ''磃']ip= .F]Uk.\4hѮG,sFBr֫KnթCp>K+tPDd9QUF[myҔrz>ljqU?/h\!"izS'%{NձKW薈*C̤ѨCudNox 07&uץ'nijޮ~Xם̫8q1'zcn]#f^2lTv353p欥L?i&Țڃ@FqR"[xVW'j\\N Ѩp~ Z @'ص8n.ˑB1u { Q-7sD]t%$h3X>;֣.$$.7ʏU>[!.hԡhkVbA*ɝQ Whs@duF[8SھȐ]O򣪹Ѝp+sѩ{^Q$W}U._{7xjctC*=jVjF@8eЭX޲qh Iשsq=ΙA2l ثLJS4h~?ևp"AyG?Ok x%\w;W5K nKL%֛R4jroBGUjⓇnG:{z ѫId,5($}?*:~_ӦfYkܘ2URh/J /f5'7Cy68i'2E]g?u?p?*r'b6Mz\T#K^99KIG;z+Oo^/Ϭ|ʇ!h u4i'/3˃Ł'yzW81BFzZ\7_뽇oq./H%Fcr<&tעǮq7؝j{ endstream endobj 1858 0 obj <>stream Adobed     '$''''$25552;;;;;;;;;;   ####''',,,   ####''',,,   ####''',,,""  w!1A"Qaq23BRSb#$cr %&'()*456789:CDEFGHIJTUVWXYZdefghijstuvwxyz w!1AQ"a2qBRb#3rS $%&'()*456789:CDEFGHIJTUVWXYZcdefghijstuvwxyz?F!;9r; 1lLT(wTĎȺk$]#^+gQ2BAPRsF&կʞPW,9QVPD$j 1#!ʹG@*x%rVi<N4膕-\ބ=8692HJk v쎹qIC@'4WZэxW/g(a)JG&H Yf%q)Rj+gqJT!,!@4琥TfКc+֋A+kZI+@!7!@%$8M h]_jщ>*D'`(h 5ه>ciT'vPRp̄A=d;46'@x (vJ@ܣb.ptmq@Vb}uԊw>,d"<֙T'nz'%6bAJ{.|   #3|Ĭz43A*Jւx*j#qĵ"\&;8 ;mTyGD8B09Q|yKJB.NkJeHde1I*c0sR9N\PAש 'NGY#a`uƪK}8q[A"QD)HpkFt.qJ"v>6c%b5c9$8J*1/0nNJ,;hJ|F،s,[#^p p44D\%c؜Su|KěEڦK ,/U$>T,2yT.!$b'5qŌwkZZW;0i%>YY=`g ;k٤1]A կ;DD hT%51A$fB`׾hϲ-URB K0;&8 aJ&/V&JJ8"0O*yD3ߠd4Sȣ5g 7B\E@U2fv&V T)-*.J6!j'lJ1e1leΑ _4qy[0ULXV0Q4G٧I­2ƩA+P3& Ux|q\SmOvuT`ӼUA+qsH imN*$xQ 'mT9[6Q5 QGOq8( oͲJ88K Dޕ9 gnǍi_{25 J>QAC ya<.nbhL@VE6)'ap'^ªx)vxIݜąuu^ 1X<P0 26iϵ-_Z%AVgaH룖$yD5ye6b*bD<}^mv}JN 0Jd! x@!A@!A@AAAAѳ[[v42)pdýu,JallT.gW̙lRʤNZm;*\EF75qcA0F.+I\r~NTZK\(A5[Mǔj |MsP%i)PpG <|WrRUESd*I5TILk2XThL(- HRT JHpA F!?!aDv۱)G%D&duI+|D!,!6٤jN*4Ű4R-%Αa4cphU0 SPVSJT!wjQZd Is'réftݵM^"RU'0 NUDBzղbȦmxYqElGAš Lо1ポ#*k/w'+BhB Ɲbl,z1?fT+KvKdUͷh2K (P0=7[d2͗9AJǞu @-J3w3FƒwʜaQ/{pJI"H:܂#W'5n9dC^mrNL9#pP7Q,ڃ^ple&@^i`  q <%DOlX!A#,cP=wU4)%b1B+®FKc3$Zb< BZ5dlë J kZJ)`kMf Qc5Ԕ){5٤Tk3sW]f|k0,ѰWv-1i-b%t֙CMxQZA8*#e$K{T|0g%Hs䋥wmeHJf,1)/m61Sii@Rq8* xG"pi3+m/n6V%ID1 Nh*ɘ׈z¥m;I%9IPmNJAyEmuMZt$V7?AiG4b"uI⋹.mfca;|zEiiwqꮷIZzNIۤpPYRSSCRy<}fRy ^q~3HVT`x\nj킁 ǗuRmrRZN$TQJ &gcS%٪`A]:#àT{/g -&b@:xv%# %42e0^e' 8 Igsq= [ mdƔ(gwRʴ>LZSB~9)QغRz^>%.%P9x6=CIŀ i98V[İ 1PMUod6@׻ǸX j\wyeR#vs76$qmBE>hI9iR%ua LCi{޺\f%ϯj%R7P\]auQ->t)"ْ$`f~jPZTTQER8\SQ4nҲcuMxWfI|QΧr涗3ӕjl0i;׍GWsRP9PL$oԗw6)EΗ=@FIgADI9ƘIq*W9»*nKd1X[\MQ"J(JA4B[y\2-X= V.Q1dKR 5Fg&.<4U}_ߑp RͥAhВ:+&Pz (UFp(ç"H+&LJ)!PU^`* "MC1[$ Dn ~ !v~MK;R|ķ/N4ЃJANTw2pQaR&RzXEAK#yMs}m! DS$\8VQW *ubhS9 BN+**B"a^  1S͊]nea(s%'ѼvBn閿:B~ Rz)V*6=QZ+ #lʹcBtS^P0\g0Xƚh IJ6Kl4, 4B;h ! ! ! ! ! x $8#~ʡ W,- |l;nʵ|S&D! JRu$g1 F!_uI\޹fp6U'=(6/4DpDq 75`gMx$.fok'RY;bI Jl@=z ϚR j q:_tƍH8[pgȳƴLpQπ<9!,!=/ގ54h$uzTI|h 6/RD%vĐH:"iJT|Gi( JBҴ~jO叛lbZ) 1r@Ppl82jHZp. .vBѳFӞ^Pu+5Q'h3%Nf*6WztOh'!<4|l3 u6v>ƮK.F#I12(do;xE{gBuF.D\%n7Q.YwFA/5K1"Dl2L 84˕2Bo)Kc+a# x{ vfmiBz &yimF {$.ƨ7KB%i`tD$s咚ꏒjAY&Xv#lŗ %S&(a[cѭ lw+S">|Z9Jeb@%@2ew:clTFY/Zde׹KgV"6sAHN` Sa hGGuvm.+HҮvقJThi⌳;596ƔSdZdU&K\*؃wH5DN{QU;cMض\Ջ%K t3vZ(mQX =V^WW ) uq CsQGcBst:! ZfDh-W(wO*RS I4JKӅTPFVtm:DXCF KFꮵuHA :hy%561d\ (S잦L-dYknVT Bw$^3IRJjT8ΣwUaƦ8l$̉5q\@h  ;F%32kW2#m\)f|d,J3TOѢaŹRƫhKfYK8)|g%R68uA͟-V@w 6Dɡ$%Or*CK88 qI^38lʵQ&+p#9]\C]J#LBDːnPxct)@JB@1TM%(*t .h\ת+7q EE[k썁F8.41N1ў>ܪANN DӇ t5-$uCjZeK *2%;sd1l[|^4$0:l(qZi7opAJЭ,\.d F҂J\ԇU9Ӓ24瀒@1Rr9?AjL , 25 Jc9q\@U9-3e0AKu$aN[6T8U4B$}d`Q#(AB"cZTlw}d u^NŠfbqI$9B8ҤCdbs)|<-7d.z.BҲ @r3-QATĒ*K4#E$H9BuN^BCA@ #BABABABAF!vfmrt0N-NzJ>NDv %ҥkmvi1j3>IMɎjJӄSeSfO-;:qs1Cx%g:Dl6G7NٽU@V/2Xne{N阏:GBۊT$E8U|n:9;Щ;BP٥egl2x޹ K- #.0vɴrJ7Lg(,,[H$& q%GWUF3-ѻ#42jH J]Dh c@ `j8pd/%m0aT һ]82U.Awdՙ%eHԎlb.\GHg vBؐrj.]ݠ]#tPZ;$k ;Zg2RYx"n"ɖ2RO(#U#"խ3jDZ h'^7_ -5ܢ">tىT$Ԡձ $MQYp@ycWhL wb#mTh 25ԋz_;V3xm0YECK{gM֋tR4V"7w7BgZ@L# C`&/=!%Ƽ.mum3K zravWDvK"SvMꀴ>1ic#nŪpԂUOGo4$ʈ" ,FHT"A=3 Rٔ+ç:%˔IPI$3 Mw6V1pHRԹy. fQkJV Ü0٦QP=P\l0n3נHJKUUdZ3_.mwo/8q@»ثuAn|t!D4{L#xa}ՐsnV؋함E.T[ )J!!5<7U榛Ȉ#l.\aAi3g<\5ΰX}͟9[:RՒI`(rpuƄ B 1%L:5${5@1.ADQvDn6lC0}ic^L/٣~crq%[xpmUdUI#άн+NqЪ>qr=ڤXmr%?)-:㡎;&F۰&?WڽNI=cl<ABABABABZ4]TM !&N%%S%!ʖH8slv7ET“INᑠ*I 4<gwRUɫm%W*u)GWMj2/cRulIIF bh)" `(Zvd!<+T5p\\gTP,$e{CǞNz<;nOBfIFI94@TuF)D;DɉSbbv)+RbS%q) 8jj: ĵFg-|+!a@Jr_>2X "c9N5J#ѺXGו4"T$t1]FWKp%p }jWYW4al# ٫T^E˃bU)*"]/+rF|}t5.Sl#=SERg 1%';c;|)*ۥL\G I4Y"rvL!HP J ҥ!6Ol -{VmhH?؀EBfNX o+a҄EjzPoIw ґ v eX#D20aiP =9^6GU]s]5UokKey;BC6Q8p|^ ~µLNj._HvtRBȥIqqSerD6y|SMGjpib[:O n\i b"LJ5~<#$hD( fw"F6 ҹy\ՐT3uE1F³3. pjZVSP=<-JݜĔ'TOX Qg%*fKPw$PYn#f6fڙQ(\N59ظwB !%ʗ%8e! <@F 6I(-Bf4b-jQu(Q$bwi#"b>3՝3U'Иrv)ٞ+H1%Vw\Iꒂ(֥ Τ)R\Qst[P=X\sBvk@:+$Eq4L|%r%Ԃæ5P {~(SS6dŦ _6ZPS5(*ؐ(x `nNv'j+7=11;5w,`U0i@rzI> V=SH*)ҖßL%gOA%f6}  ^ū5og{u7w-MѮT 0 1˖吿l.GZ\usyY{mOhq#8-D%-@ o&by B.RY%+mj*AKIH3rolL} )H7^hF#5ce lYMĶI5<尐SNiRI$ԃn;&L"Q -L~:ՏҌsh,Qj",!*H*JID;-,wyXvZm`rmɱW%{A CZX[~#znԤh*AZN,lWo$|n$ e8ESS9 8䀕\r4JCb-@'tݖG66R@'<}FL(5 AVc2\Q#B*>$BZTdOi˪)ؕ,2Q2iJY%jI{\aU['Dچ:Yc Т&>K?p}apaf ^9͋@P+HB`O(mJTުKˁpTU'jLmB RR"t0&`A$fV@/|dE;L$K=AUklYi6 yn,=n4ΘX<'DC`$7A9GܭW)-LoGgv&Iyr.ؕO|n^0nl&gWk]ܕs?j=6QZŚm=0aÍqMZ\F$]+GJG'⢲7 CE`T KuxIU,+Τ Q4:i mSٜ nHe(kXu*)Vf6|CXs($XXr(Hלp\M\2hײlI0JZ"kaˠaQYWH/nՐ*Z„ENRq%n'+U80Cj w+!C[E;$ɧv u"18M‚=aJWE&^Nt Q2* [>*VJHpA;qVϽaXG=)cX TZढ़P4iڞR\SQ5'U:Eӈ0Um*Ba\$i#!^SB˟0, ..GIX%;d8OeҦ+#S2N$Գ66 ¶yBjg 4(VXDz .b'!eLHRT* T <BAAAAAAAAAFk]Y#F:d[K Pt7h<0yyx7Ss;XLHBCQ3!eLPٔ܅'BD3eXUVot6uI $a Zœoxg\DkwjC4jeu~#Ąx/f yfRBqh6Iv-Y[y5H}qNڇ/n1M+eJT2l@(z%aYQJRkpx B Յb[j92'yEQT y)Ď5Q[wd5Ah"M咏l,ZXI;>pmhcC`̙k.Jd(I Ǯ6j=n< Xn? <B@p-44nL-IK 1p}iiyV8 8 {Z)pb'&YԼAQ$1d2RJ éN-3f\ÈRBtup֤Hv.5 YIzV!N%BKS:mJ iAI~vL QBD>:j*4WQϺL *!N u h2+Am}ēJ'AqglcOpv ReNXҢ oMd)/PRQf&t}(=PUI[Uˣ-bcJ""2<$`WEWJ`_&>ʮMlR jݖ=7_r*Gg{@ʘp*b@aHF$ ;G:Ec%O^~ƛ)"V'%$\ XHR@w_Ve-)JR{DЁIpXKѱkZp-V6{CiPIXҹ5"sP>G"MLDT/'jTe9vM<1N"JBAw`AdhW%%s/Q`qp"ܩ$x$F65!Rոx gYxޣ@R T+A0n".$Tr手R._i%ʙ06I[BL*YvuN!9ȃȳx ΉSȓɠMO@j"w7$%)Y41}^ݑ2Zw@ +58:3msSO}`}bsN⪦nmPE h0w9KZ;#' wR3JJR FNةVI,gSۉz[QWo=HFwn+s Rw&8tW5 !r>R.,D|;LV$υ1JI Բ|]e  TvfXN7*zK 7J==a\$n8J}1j+2 u>zф׎O[lnv{ \N4Vm㬁B ! ! ! ! Fh-Md6>!aZYj3tݨPx,G@#+ׂvʐ W>lsy\izciӒ%$&OBI))!гVYA#e(,pqp*hTkx)f{첝{,QϭGhDBhU0o+HŒRDE@Zf\UP^pjS٤ܢ0LS'J]J%S$r@V&觎+ؤ{K4O$GOS,:s^u25P(|Ձ4âk6wŮm%U:P6j qR6iJK$*BIm( [^P:Pg*V9+)čIH/Lh2%{8T 5uGM۸TԎqcD`Vc fkʭk\B*f3IjQhiSVg-E1C1fԕKr 2HrRrsoW W2X_f=UX{yN#lcj=jimU8>)];W;$,tvDb]ct 1ff 3hmrǪjY4VT]kbja v(I RWɓsK;V6*|s];&xӣf`{؀|PY~J[2J׀/ ڈJF!ωjld{18רuGZf$ôR)٪\8ұLOD0C(F*滤5t#cTZhHڅ9hIyxUu"ǴOAR0]Iv競6ʒ _[1dz(kdj\Vk[J ܖ0r٢px"3ִaQI, UCx(.ZцgY$. eZ65, EI>bEwrU٣e̴2Ip y4sdo,n#BC%nMH8SN"hmo.6kFk[@50 4Zqs/y0C?ur6PyےH_/fdmvӵ`3S- NElD.T% C9'h;<4J!5b#^Wsf  ' _G~YH-8qYmrh`1Q(ne 3iN[n|T_U̚$rh{<gg GGs( V n 5tN$aV'!/ۥ Y`+ym{$&Pu*F QG&v9=]AKG_F p41qqpns$ tch@+9IrPU(KJNY4c= RŻJ2,aw&LIbƇ$yėS%SU\"Z9˕)-]OK uҐQ+O0Ku=}S&FiH B̝I Qw#Hp%pJ\v$A)S-NrPbʓNHC6pl))p <8s2 V]mF*l "Y[B(â-59J,CtQ M&tS6OIZ7lu;qLJDMlouw ٬Bz:8U]ccvKD.g}ODFɛ^ιk[% U1SHTD)b%RG +m=bAA@9͢(a `;)$g&pq+3ț 8k+̃Zpڧ;.;K<q\Gn㖤gIͷFYdLJ٭3Dc7j(QiڑL䑋0Pk’/{v3e l/lr&:b Ύ5VjR\^ k3t츖+P |,J'RxE٦)BY)z>gA$ xĝ#fBI5*Y#KuDŽ}%n<$$S,h]F7FfusDiHRޡ@rl~%RҽKAP Z*oZGs6YajAZ䙅v5>ݭ$p:dl|>wnbek1 t>=t~0ònûH:S)%H;q}ћQT5aVVwz%Q*J %kV*hq|nDlM"4#Zĩm\6`l~߳lɑ*beJ$r^n2xh۔yTEaPWh,Ϧj7w>r(hVGV[I51K\+m3[&R\)BHn!)0,PTQ>q&Kzq6mlB}ΚEz1qN"n1`&4pkZp$M>٦l,/y-"٪'mdN!jiBHd5&%D,@함4yB"ot(ْU|jRͲȔ-U"N>grݽ{0:eth=D!x!!e򓴬(v}wfct{|HHI:CxhfdK*< n_C+^^>Y=[:%K!>X(I{+T٣Ygdc y+3IlBa+HZyf< J!Dݠs^ТŚZJXC4%*_64ׅsfe9Wp9AKh {h;Gp{g*K=i/A{;fY`v$NS^fWަJos@,w%{t&1LT[S%-%H{lSq0B1aK\As- RJ5PwΜ'%,x*䒢5-Br2K#:%PSƷJd|b9XX*]ա@]H{̑3nD $҅DT$ `qs pB_7Җ0 qD6uz$(FE$^h”.f%ɉQf_flܚ9X=G53@| tv d׏%ݝu_9Jg[<9DYDE*2dR-jPDP$B-ثWxzɜpKPGۥʒHle#N >gXbWnq_]˕B׀7Y;S2ZT*EEuWu$rԑB:Q*Ӊ$j<9LM)1GRP* 1'qR[dfoZ\!a%.ۖbD8Y-Egv|`MÙ i- ݴr8\1Gy-֧R<2kAnn)!C0 |>a ҈3sAQre °CbIb'g1x$p+ 4[]ai;('-I^OKsڛHu1-]J ]0ozlZ)%s#R{9at0{-d$܀FDbQ-Zi`[v cSlXi59;BkjfV61pr"%YadS ȸ յr 4O>1#X -I({74Nhq <[9eC%eX<2+Sdw^$bKR9PA9I]HQBTEz4i){:B:Dw7wsv!!j Uu+,@JR!Ú؅m1Mr,Ϛ]Y2nD%le5x:A$_ZhG5)O@ ;˲2cso:  l{6F"G*I{;/*>9X2} L^1İwOةIZI\::<&=g{=[\A)ٳvae!!IJIztrzwGrAghX'jQ= ֙]%T//Ｅ(eJOp6)UL$ ֩xDGn^qօDD?fHl:OQ-.8?.#Dshy#7.(jWKhA60%8zm; ҔqR+Je (X+)FDW֟srd̘BH*2Rij9Y.A[NM(2%T*@ JGmK?ۖU }"_¢Y9qv0f!SEqhZ!}>Al2% 4Q[$[>ǻha4=®|JTɞR j`DJZBT|Ql|ZIf>1ؙD(̓8+c>:JZ8FGs%[̌ĄҡLJ˩G (s&~1^ڔ' u1eؒnE-K#.qA! ! ! ! mM#K8U.ZC`: &#BXUTG(#] )b&ޖTؖxBf!R+II(1HV7bS-|bH-ӗTB!ZZ>!@(LbczR*TÊnWunHV!  B  B  B  I Gg{r|pݡq#Ukܠ:ues'ᱜUgGm>>rT-RIQG;&JwLU+aV.ZAmmHYGr/YSS6̹I6x%QQv\*аA+!K]H~ӳıC(J8$nLTƃ9AiW˞"8֦]uf-;Tu =( 1tRp)OaW^y*謌xm4b"<GZ@2p)S%O-ҒkN0mF`FАSf:|N $ eB)hKq2 3X Wm4{1l',ٹ Ꮗ *a) PIX&SHJ"V.?pZ0;^5Z.{1\Qk](d9jRK5 VQ|)LE@3$j(Zth\B,IJ kx, BABAuqDAeu #['ĘsUi"gYٚ5 *e"k-s)zg| rU%G#Hp+}%*#؄k#ڏ{avZlj">G^vnr1sI7gŸ\t>֭ftԄPE=H쎓fDɔ AB !DAôe9C +Ty I1;9ދerͱ﾿,7;2%± h\щCЩhCGc M9E$3v=ۧFc{b 9n\^a*\؄#.ds_n&}ZmR:3{9mqQ݂9֦y !!K-9@-\CEwO֏lc&Zd%Jf Gd-%ӵTw L!eB;u-((% x$l2Ђ@4Ai/Xfl=ܚ1$Hйfr *vB QbDZ>yk]fo;4{[YwU:+-v\ZwF yzG+cH.y%/~[ͱXFͲ"P :0&܎0T$o?}8>"YLIυwMX! fۥsj(kP 1H%:4x¹DiɬALw=SwWbTU%`3 d$ gx+b " " " Ub{6+! ƥe㐁æ-h* Y u|*3#ϖ:Z| agN !./ih4L(ahB,@!A@!A@/IdkEͱA6hLa'ijm{l!SK,p=IJJ<$AVaDrDYI93 $J\ӾcGPmPA-) b%`L+^hkr< qcV2$N 19+X*GUw7dڶ\Xg`Xֵ5/uQݝZeR촳h⠃>BA@!Aw}U JB``sE@K8p>dvA`^6mIǁˣ <5!lȺv=B<+GIzw_lZLRN`-( &gbUM-Zc8p,сWpfGЂ9l!Xe._i(_5A26E2& Fe EZmwi޺FMk/J3 ,fD~%SPlTB9`s( հSZRd;{9IG.6Tc%c z,ctӱhT\p$jF*dAw#pm֍UL!#_:z,/N}i,J1T`/9gO)L_W&VR{e u^6HpdalÁjUAO $JXZ DcWvv>ʴ)׻ }! oPK%vr¼6:] FwF7I,a'XEED VJ=\[C YYwu&EJ #KGA13T(&M_.i(<āIwcc1C6q{ 7]S# bQ|i^=*~9u+B_QbkܮeHJ=Qk`3`I!KP7Z-juF4ua(K =m"*l `W] [z NI8$AE%H$2i!&.ǶwVj'-BF=ovtb A/k O'숖|î5&2lvp( } 14zhekld_-B!KeNqd#O1x%DPxcIضɍ0&js&SϞwJrP%Ek{SdM.FTQ٤`^ F. ^ֻ%cBbV4/ d>:xs"F lFnڠlHr>ӵm"\jT) 7 @#"ĥY$6m;&5sZN&` Ī ֙F6AV״˒D%T^bko`m+i$>vEC* qz0Ghs1렍c YXb8I#kMVs(c6_LJAIN|Q`>}$uU{mr̥&V9kB0LMR7Gw?jvdzI"Z g0NRs}2 A'lx 6" ao2nm%mw 1p6h mLDӻz:T vܫiDUJճL ( 6=̩R6]L!$Ћ 7u$t$vZ8rb4Yώ`])܁ƴiKFX^ۢseJb9JG8Dcu'ڗh^pu Ge]¥(5XžDfP;?t+6C,َ4;},OeTJ>v څ&nG璗Vő`L]Rlr8ѭ%A)RE ӻ66vygo98Qzw&@W䚓%~dlSPޯHR/3S=a$r q7C݌W R mfY,B)]ӶCx7G7G5ov%Ν'*laNdL 2B.\p@.H 'q[? {ZD+8 *zEr>}Q X/E-jq#bdA{QTZ6[fE%MV2 4w%9:aJqhsu rWq-;vI&KBYXRlAQ"ěWlP*D %c`Afɳw_`=G;7fIBvJy0TCMqB*b˾)* #Ѷ B+$iܭO"ձ(q8.Fd35 ZX,Zgs=l&L[l$ťK8h<+g^h zЀd3 Т`)f\];& ֶ1s( Ձ0`BJ!dIr 5a֥= UH4kt +4 Xp6 &H2f$1JRnjrPH+T^kub"Na~QnhU1 L"K%*KÉ/pLuAl*Ě:wW^#*݁yCc5 m*Ti0x"6smA ()ITMuHIF ԜiP5JI5u`I XTVDD|IZITɁUQ[݀F͋v0fTS1[FuLBAYIQ5)Vq`QHHMb˹CR]"@^JAv֠^#]AFngIğ!*'|ŕLKJQQAid+p7eFH)`ϯōcp s:4.ѶhtD xJLfugzi+i%;6)skJOJ 貆1NARaO4>bK+v%MЬLl$$(o{g 儖ctzq ~6^S]ajeR_a 1o(Z!]I{mqx"Vʢd@Z>߬QRJQ);fF+vr(Zd|QTKP3ŝgl~˴-@;BT1 j8&n(NdlY@ 10!DA!DA!DAVp5fwB6R:(N~.ꨢP)Izh΀@/Qo}vVK'ED=i%n̩[vtP#vptMj7Tz,-\r+IKdaR ɲb**q1-( mbkKnl6eR.rJ= |!S1Nԉ(1`.8ow_grIJRIV$ӂ:F-%'hĔ\0q-{h8,1h\l 0U> 5(t`?\$pnO4[=N΄#nnJ;ұoOtyhwex!JBT*\=nS )Fxll5(F@[< qkG2*6q`mfвW{h"YSgJnE^fBT nJz9~3ni&9xcp\M7mq9֥ri]!JLeFSEvȁIEnMKRЄire*0E&r`{ p @ŒX]Y ,T dI o3cs Ib`-o6Jf!LbɟN% 8(:i VFGAe9{K{.y 0)DZ QA;S2ԴcG+~a-In-n&TC$?E)*Q>%BcpAg:>֙- Of#qyQ8S6gogSSMAI6n$ijTK nL!7Xt&JP7B21ofbKUɥ؜X絗jh15LOZΠh{є҇:Mٔ;:>2;%0BȣtcPѕ;$v䃻JRH!@EARɩXP,_F[l2,\uG(aDʼn ;w&J$LBŷ jDTf T J`xF҅QmTfD+;}@GP\ˆ?urS*z*(,P)"Ń'xq(3[3[PT**U@s *ZֲJhkn1=AtE;h8m;)p7Zr n"",Wtg+R߷(v͢s) ]HMb(+]F4LQhikP .B3W};5sC5ʆg22H׮>*P#r/cL*V4'H?TMc,#0[mh kU7 lQ2k` g3%$̸рsjqbPr(/L8qA VPnueϬxqHhj14nF $b>vnn݄PRiH;DŚvI a$ZI4&ҞTbרfeIJUnH){`&_ J)SF[V Fd|R8` ׁ1m [~7KhERQ{<b)Ub•1r.AE6yrG:1KZvjJiII'XvZAFhpU)+m[a@KLmA55J'ԡO/ (rKIggeܽbh2FkLiJzR7rڻ1IQADǖV' BN! x " " JܗWx:ݯٿz/#ieZj!V1 AA@ 9Y3)A&@us1k۽QRQd؉LMą ۜtI|٧3zHđ\Š(.q1^鞴e18&D}E +I)A"ǂ,16"pec"#m(ItKF RQ%y u>.ٳrXWx{ .lkFRƠʹ=QY-1blonoh oDCG4K*LR*ASӟ.B–; ;Gٛy*2ZBJI.TuFy=^ȷLNR*hf$moŸBP5/rUz+|] \< oT5i,tvAEy=;c#ύxI01R$) 1NQV01R V߶eJJ攕S8ѣ sL0:: ("5smF6aBEql܅(I+MBOn;k;kN:旒yịFUB+t0T~kM&@9ֵ")IPXXB[W%% iGn$G[\ӈRYA.z ZZ=)DrWCWA uK;&0+5U^s\MI!X je ( t!)_V 5yQƵ"X@B$$.ֱVϼ&A̮`*r+|0߫dSp@z-ExE)) E5">jQ)"[A0#,XSN90b(z)x WszC-#^3i27 KE1=)n-9bYgS:ZU\o ؔI. GϜAS%vLb6Hzb-u!Ghh~jy-$:o,vmu e.2A޻ׅUx 0""xyKf QB1شDc}8'Fq誛b]V:l4k2ꮙC~2w7B#R 1z- ࡆR@ wDDJP*HޖoM:x j F3ZS[ +\:'6Q:|&8YX%"1ظ#w;D*sAtvsJJVk3G H[ئl{*tBCľQ^”uuU@&:ԥ&131na. QKVU)Im$$3^&28劬)(1*O- ;%=nGМjwOM#"o@R EkE'="@oS5TnƆmאh8l32t;7lS'YtopI8!'>`%%kw iC(.#ZSGtTs$ p*N~C06ʍi eK,é'# ip,l)RJ%N:U"Ie/hQAoah 8`VVj \\$kfʹ.Ks*a3A@C\">ܟ2# *IR1)]n H`MK5o>cʰ$DA=bx:HI_FRe%t 1Bq {3A\1kRЉZ0vT 5S5"2Fat^U\|IjO<" _)H!LZ(ڜ^*KsK3QRfʀned Đ=;bpvo1:WaP@q 4{-vKB:CtVZ[nc v9i=eF؟jiip;g+*PP F(%5h_$oAVJ1)zXgQn˟=s%R'%]-^je6 gjhB;+$eHDX,dOjmrko)-qFէπWc'+P+|C;/Yw7B> l|-&s ` K3x3\tϊ920B'g$Θ.3][yך4)[ @'hJz<=فf(513vd;4u$biCEVVy{  /b] m>"9D4S&E(_B06B|EP7h_ %QVRkvoH+Ah k0(eLQ@QQ' hV)))`;$ S2E` 2`.jrjL͜S@D5:+bfofZS%TA2d7q%ܩ[a S:GfzVq(Krtl/ HQs;2Z%4i@(x(E#( V-^KF$̩bP~b 3 2@翵5l+ZSF?3lψKJ;WuڱA k^ZiΠ^Yvuk ; '| +"BcB96`r֙`w#5p {!9pQdUFڡؔASR`taHq'gJ@!U$X2]\4ɊjW4G 1f]+xtW#½&.;B㈋$ԝf&JK R÷2IN̤* S, @L:A|@)C֗h!;> =Ls nٳ>dFD6es íD\J ('e7lVnhqPݾ&.m1įn`u&<3(kXOB`{BW˝)dIJBqz|;v56-rw8Tt^ NjQB )vFԎM[.$#zB3Y9 +a" " JܗWx:ݯٿz/= ]!0B!i)6P#\$5 Am+-&$vŹ>hr;,P @ Ɣw%AI J3°a90ODI ƢHp UD]Ε9\A I&Y'=.{$,2NE42dmݒw`ip#U as$mt*dc!%p0 7ic4xعe: 'hNЉrR.Z)DY;eLlwEDRǥY`w B١CF\D\–i=ĊhUH%.l P3%'0D@|;l6IBPJ*S5P ƕWd"7"tT.pA2A+;ŴI6ixgcn6=r `tsXJ5]|V\7JGEPBR-є|[DI5֢ -z"h"ժ'h9Ë5O ;3^DFwge$1)& fRԶJ-jhJC*ZW V)2Q$F|Ђ7H8HTn꠸+C0ᎡRQ|9JL FlUd(%4j): |Q$Η͕0Ĭ! s5Gȴ2#HӻAg058lo۴EN5H#I[V%(!J]uo q'E|$ ej UAkŲpqSw*MhSF )RJ,B:MKN A1r2ִ.S8Ã϶MZPҊչ5*QZ]q.炩μ(EDLo.R5}Y7$ 9;zЄLE2$gV$(3% +j5[\bm$pkGW*鹎m:igyrb(-i:Gy4 5rKƩh,.m[aAZfn+a{TmP@*d(}ԜC{$=YުG˜W=[ 6 ̣1Zc$g̜P &FVˆok۶x'ˣx~͈X2 !EH'(=Ґ&LRTbM7GY J$Mxu/ Դ8-P@'tP7&ph~4;Zx}͑[PU2Z]TG4'M^$j;K7,v[:H fS}$5BH{BhM+-k` Mh׀J-Y`\wq*]0c/i4 u/Od$Jm i?fgO&opH 53VK HHKa0m3%^)i)5jȺJY멺cK쪗.jD@PuM*YrJ1Ϥ,,4M7CZ4{2G#%})KNɧ7TԌ׫<و+B(HYX`$ C#bB Gۦ;&Ҭx%MH[ZVz;g!9xq!ݣlrD΍`] d{M;ܪTahJŔ{bRI =^wC;$]bPOfI)R+V!  B  LƸZfإV<^zpH˔ cc;HQ ¬ct}n8g gc}N:ZfIJ10 I!0t氙T%mrA˘:RIK6mƅɟ$͒J=*(hABhxGXqɶhzcLN4):0,r>DA%(14"8!tL(L WYp"Xl;JRGJ"/zopъbCT!1rC h A.o. Ai)PVf5EBV,XgJƒKFkVvA6׍S{#-t7mqQ2UˡZ< ~$DStQnov9#9[\)3kL $)[.J(NqGK<}3m&ޥJ(kNQ()`%C%z=Fe"q5*g0d"KTͥD}$Ml" ݐ`eb[/RR,ÙYei^Aʙz)W4i,7t^+{GW0oL zaJ˽=1_N™]ٙ7U3g3.8PRCU)[FJɔE/i<2IJP&w:In}i!>k)D+U1*/yX^wpʛݩ!@ %FN-t%)JJA#u9HByWP(+يV$0o7Y pS.Y|k4"J"'p;(b!E +D%~ IUֹ"6\jĵ(;SGth2Р1 DGEk8NJЂl2U 1 &ZQ.[Z2`J+L [6I|1jR\cLtBE#ߎ]nS3qn!IsH>)GtݓRVh슦1Egun}]-hRF ,я KAI޴a"}r*6GZb%̘)\xnx38%+(~zA cԔߠ<)a( ! I%T1> }b 4S~%|87+Aꂤ$ {JJҴj tj[cdl*RR`>&E3PuMl!k+ 7 lrԐ vp36nYŖpTK8d,{p凗UڄvgJ %MSCxN"s%|HݔVRlZ6wC3˓6f"vPޢW D#kCn%RAn5]i5'JԄJSR`hX5Vdz 9-ROި:THC6j2HHW&V 0Ս`A UD+ 1U7%)|.\kPSSB.M>"HqRNHj"b0e-2Uj{ԂRBǤm a)ip4VF%UV tikpM{4U* ZMA#GEwOfR$:&E*PC)Rͽj] 1KT +٥$6Xa@5'y_h) b0_vd{~'KʀH1GsLO.%<ڈRU1%JsI`=iQA 3I (|eK c;=E) CX!ϴ2I~橵٥<`*:++d-p;2;3hXtRl:hvYr6u^4'=5h]eme"IRYLR@ޟOP?|f٣,1Z;WJgLI 0:y1" i$4 0)Ill`ҦCR\0PaPs/L&O }.l6YM"'I d )M(<&W,+vA•3A`X7N…Fu*,/LNuQ1Dʱf*ݥBg!0VG!%PSk\SA1!a!q|bJ<Ok*4./gΓ+U-S-@]3O\pBzG@`nwLH#3_tX)̖ؒ=2rӈ(r/|QMIq*0Puu1>f/E:]1ӳOa>be D,L5'ѶF%ؕ8hr{MW(u/ge0_N.^"pCG#TKDƎY FĶGʛ\ JqD[Ȇ ݆/vNI,%=>r*5MJuo㎤BF HR>_GUwm%&dbӖWdR=!5 /ce- T@)6>dU 3)QO}Q4$h"^϶JHR q8, z#ϹG jc3X.:˻KHZe%-F/ੈ՘ ‰fQ^h,7>iqgdd"^=UvpbJ238H,Nزj$1m3 Yօ^*qg*-c4B=Jf] HROOE/fRBE0HR1}X=i JP-+ Վ\kLAaFxcG$ IJ "Qb,Dv#l` R3Idұ[-Vghu^'9^'P>Tmq F@4 8@#or6aDXgimS[T ٣J@r*\#+l:XlaPM0K$i*S,?izMFHRрD fm6)G&S:fZ>ʰUs%G V@-2(!Ptnk MAVJ$aGF ZF{ZV޵3h=Z^&2HܡVwg0]=[5cR'"d) XRV$)"vqON"TDHZOZB%@K&@~ǯmm4,ݑjnyXV-HƄ![4AAAF!ϴKڥg C ҴHZMRb;L8CcIZNU aˠQ/E'uD{L͔HWQP Rj tJIrk kN^ӵKp.{ʘB^Ҩ.w⸤yOQpRKisgQx0xbR'(DEquPAB0Dber7w+GBL h%cU\#d+<Ը8 ݘM K5Tm>?${m[99=jn4/ Ґ$jRqt?a> 95(G6: cvR.VC_ k)6RS ]\tmK ÷nm 6#YK0!eC">XRhq # vHr}#Lsu Z(Z>ƞG֋mTO)+ ܞM~L%\k֠7HK)8|{ g)*)gk.Ax"+3xJ{R*s\:*M8;:K)*QI4$FT3 7 )GDаBP9 $&5g)^:\">i+`.jFQ$X+r^;MZ4KT e-O&$1(-lג[5UۣR `P~HL3Åa3x^/V7p"OY|Jɩk̎87 P zRpq 'hIDfIL*MjUp;cц%DI䤨+W,KuR> ,dmվH%I*ЂAdb$3TòQmN`8f}26EzQ؞bR 4/[BZFicB3I^*>nؒV~ ᧖6,TzKeF2iyLWmDKe TZ9ijٝ1 03ۮƼkfxvDQ\0-bD=#҇\ى % @uH̹@w1M{L݌H=`zA ڌ֋; UDD[-iŀL%NeZ{*{Tm9Ypo3zG *ۤcȸNn"Z1` f>(8BYV6KK*}(B83PFښ+.jQ1D2!֔jr'#=C8>!$Qc"hXFSF.1ԡigRi6 $ SpbU! –nH5'gYJV\EtSTVTM{~̢'vR`@jb$7>& x=ct`lJxj&4 kKukiPF ) #$r0 5:ۛ*Q8PWP{0N/8A;][V¥R|1 Ųrp1g{OǴLs j`_UyB= B  F!Z=a*gig,t[B9DXZ>ؙ2TeBwКZ@G ^hku;J\3[g7Z\$kn8Dւ6C}GmkI'pRI:/ -r{m8ag,k$(׷vݕn%!|OϚZ*rҩƦ, EWtfU=)C`aat4xy&m= ݩVZ/H js.ѳhܔS06661`QrOu1D(ϊ佨JV+ZRJA +gCBBN:f-r+*J(gp DܨwJ tD}Ld$PrSw|Lۦ22K)Xdhdo 0@44R!Tu d9 S'w*$!ٸc:!N KKQXxT%˘ʚ@Ԕ^"DtQrsZ hbIJ73&jE2˖AĪSӋt1i .eEͅE UlC;$/,VpS㸋27>dݾH&v&Vx2 ƻ+0@┐9֠TPC&R!sej8\pQ-1F e ^ٴ)ӡ!UQ=Eڧ*X4 < N8t|Mk$ I%تkTLc5FxT7Xv`G3V83`Kh/:)x4b#LK6n"h2S#,;|چej! dT =ê)OpcaKy&S%ӽZ*d5'tDDsHRݱaS*6bOlg# dJ*Ѽ1F<J9Zj݄hAhus OyH15"l&*Xã,.@^]]NG,\ҏUP3SNEHfA8V ܖ=2LW]x QQ qk.ɰlru*"ꖅ7e|!<)2 RBE^ȉ;>vii/q YU<׈LJ^;$BX娮@LZ QsA j =Xy@wn=1bs-$ h@s~['tBdP5Lo@\t+DZZd`^8BZ;Hky$L J]$AlpzR[>g$ "򽆪\9K>s^:.g*%&TkÁ;0$ʜKd<AF!R&RHyXEݳh 5p(B8!9DX(\yGԇ B0bJ\jTܳ 3o-bVhdℵ19AĀ1CSE5?]kQQRRUz%fu,A D*$*) 0"^+xW9R-n֨RiDDDX>ܣL36T }iHŴ ,Kc}㡕p3V+v8qUPNr)l H$«Nէtلv -CP]v!NQDKJ0 4)f+2{ړ- P$uG 'cZ,̷Tq +FMgi©rVlW :)ʸ4.{k@̓Ms̴Vy4%tq'wIme٦l\( Hb%Z-,4ɅdO4f +WۢѬĄ!H,Kљ˖-{"N% ̨ā^ }d}D"Z bƜцAr%}8H֭bHI*±#Ps'EYvtAtF㘠V5g+Ih(LKצHM6BKsK%$%k)ܩ]V*%@"ң7D5aN7gQ(%EUmLR2dX^IR\H6H2H ! '3 2e* 5|JcLjTɧ!】Arz ]3DjЂY.lI6I# gNLэT3] D GwQLL%K4"8-Ӌ6MtR UThK6!ѐ@48Bgl7sFhۑ|T )Dl0%O)a)Q)r\QZC:q8ڥ`Thl CIJsGs dL,'[/l&-$!L9;5Q[a#KG BȺH L! NpV58\Jzh=cr*pUl$k(:Ul[m^8"Um`| ,T('.rYZ>.1f^"5}dvf)3J2,dr7cD\1YVU>3K h:tTЗ} ;q}R>,͞(x>;ݘ0J!ma8Pn+}q-R&p:jS4ѣ[)8lB0 4K[\kUK*}fvӒ! r GtE;&8 HDpd&)\Cxa?0pvB>3,MwDY]ؤ%SKK4PPDAA/4Z;gWɘsv܅S#kOCZ7f>x%C `zEyʹ#k+h^\HV1..! F!{L.QJS2њNcfetmq,B(I:ק6Ce mJJ$V%iVo,!­ БqoWm:޸XGl@s$M~822ڹU%h SPܷL[-A"]֡qrv|;Nȕ)L!8YDH8{ܙ=63I@TP(%J+{p1=Le Ґd$.!h;݆zgSvK 3Jp RM-$w<WsgضIIJҥnH 0ƨ B  B  B  B  B  B  ! ;^훳XxFܡAX>˿yUs7U-z(/`tRcЯ퀈V fKm3$'I%Jl4gؔvn' dS\D!VC߂ F!ёuVeֹpsMȤZ IcxU%BZMBW.bJTIIvE&zdJ^5.-ېZeLO4"%m2&rsJAP Ul/`VQRI>R1&YΜrSHTӔިc^HRKnjBCD!IӁ EuI0&&H`nR57C㡈QIƅ$PXr=FN$.E:r=F1mER#,m -%I9iL XyFҬ{bq -OsL0eY0n*H|44V+H3yQܺ;R+RLIC!Z{cѓ LNd;Lj/j|ϱm5Pcj;vIxZV)3NfHQ"RA|F& .;TmT!4Lqp02Z$ 8e)T%U%sZgv*CA>J;f-kd hGrvNLn:\+B"bleD$EAAAAAAAAAAAAAAAAAAAAAAAAAAA/vc6T1cbjJФCA,aVI \tzJ2϶.b)N얲JtmIP(z[ Ss7&<طAiJŔ{kN 3ۂ0whVհH\PNn^ƒLI#oF!n|ϵ;VFjui4c}( B  B  B  B  B  ! ! ! :" " " ֵ4`.;ǑA 43HAڤlh.H bҁZq!],íccs[RyB~`wi);XNUA0wsc'mGgX{P 6MNɤ+j|5@-L+Y[%&GhsxYWJR<Jj6AQx#A8HfmRd TsVSSq8>)([FS-WDM$:DaS6Y[օ9'(y9pN,jZqBxV{IOsJz.LG!y؛^ iH+U3 +icN]4#"tZ FMc8@ 0i2o_,)_ԵJٶtvTH)LB@JA,Fqz·zWs;hVO\F!ȕ2tcMHishKhMC#.ݰۥ(kR!bIwE$I$3V@uNr* =:Jf:bf+eڒK&!MO9&49! b`"3 n]w!Q{ otnͤ0QWZvl챵DŽmYݚKKuvvBLϥQ*]֐a~J9Imq6I%rHbhN"VЂ-+ ,FQt|Fo1mS#1J Yb.+!!DA!DA!DA!DA!DA!DA! knȂZ"0AW6|%S"RC:-(!],#BA=D9C*l^ /*/i_xILiRKaeL[ (PVt͘Jڦ/V`/gKb+dnMCڜ z(۾[\9(eD$xʽ j6AQxGӂ>g#yvm:Hc}JA J>^v{}@Ģ)F$1݌+{Ĝb#sYH%qDuӛAx9ACSگ6͟&@6b%֔ \{e){Ag2F!$uܭgPTJT XpRBc` AAP7pFpr1xGEyU(G$O:b >92yQO@>o`w>kyl-{:7xOym~.z1HH9U ҂."Yx[|6 nT0U.I [.`+.c|RL;n<:d eTD[#+dPn8!Y B  B  I2=p]O%RI *VW>h*dS*Z@!%E#uQ3ܒ1]KL7'H+I*8ԒuKN%>u v# @cU7b/dq- \m.Z! FLwABABABABABABA\]DA81:i9is;P:/1ww*$>x|8dz Mdd {|.db9 \`RM[4gH@h&K{[:N\Pc]zv䤥\$ҡLre7 oey];t('JÊ#1Pq`'j\䶙-Kw _ iZt Ws]wljulCs|e".i8&kV`RP+!AAA\BAy\N J *l" EDZPu-A tGћpn[ūMo=G*!z\^QQKݍ' gr;:j$lX0um'`󶉲^3AX0wRo:nͳ?'-s -ZЂ."Y7vC(;#:A(hR$FjWj`| MOis<1S=mS艾gKF*#Or;!XѲ}iP͓n ! xP2& B  B  B*2V2  8P%BF M "3dz&2P@)Tą9뿂+BYF2F;[KRE͎󷁁<'/,X^UUPcL!n$#hO>:bODU3xn_3KH\[D;:[7L=X 6cFy;s B9ByFR| AF#06aفgm+O q-oufl$cV5`p$WkkhƗƂU#l&68H$JV&7G!#Q''=GJaDgكϝ.PvyJ+S3m;Q7F9I'\ R%)5fqHضyjf% + Nr^-[AX5;qj o?4M㹵iY$NuB0M7!jY|£T=^wf3h4iH]fi܏skL6bH $P1Fҽ`o)wQtZlbum^xkqY+* )ֵ [JRȖLfvi/_b*Ym egQ1*&۵m i)f^ͳeLDԤ̛6e*@![AF!(#>6Cpl hoˮ7 HHD:"_1>>'0E9hCyЅ #J HH!7! ! !uA@  ]\]DAAA־^^TJGm«i-"i"R a&-~Я>wv.WsZ "1cwL4E&wZKnmhwDIG'OX ϜeJSLze/"`" " " " "  endstream endobj 1865 0 obj <>stream endstream endobj 1864 0 obj <>stream endstream endobj 1853 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\034\002\025\202\001\025)21(\222 \006)-10(\026)11(\016\221\016\001\220 \221\025\r\002\016\217)-20.9(\201\016\001\220\203 \026)11(\013\222\025\r\025\202)10.1(\025 \201\001\013 \r\022\007\016\017\016\001\220\220 )]TJ 0 -1 TD [(\221\025\006)-10(\026)-31(\026\002\013\r\024\013\026\220\017\016\006\n)10(\025\202)10(\025 \013\001\013\007\216\001\025\202)10(\025 \001\016\201\016\002\217\013\001\220\205)]TJ 42.45 1 Td [(Pr)20(ognoses of injur)-30.9(y scale in sur)31(gical tr)31(eatment )]TJ 4.112 -1 Td [(of post-tr)21(aumatic anal incontinence)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0.273 Tw 10 0 0 10 42.5197 724.8299 Tm (\f)Tj /Span<>> BDC ( )Tj EMC (\030\026\035\017\004\027\024\005 \f\021\036\023\036\027\034\033 \023\024\ \r\030\036\032\007\036\027\017\016 \f\235\017\027\022\021\036\030\027\024\ \020\024 )Tj 0.248 Tw 0 -1.218 TD (\022\024\n\023\035\036\022\f\026 \023\024)Tj /Span<>> BDC ( )Tj EMC (\007\026\027\027\t\n \224\217\211\003\222 \017)Tj /Span<>> BDC ( )Tj EMC (\230\215\211\003\222. \200)Tj /Span<>> BDC ( )Tj EMC (\017\f\f\035\036\007\024)Tj 0 Tw (-)Tj 0.135 Tw T* (\r\026\027\017\017 \023\030\017\027\016\035\017 \031\004\026\f\021\017\036\ 35 \032\036\027\013\017\027, \023\036\030\036\027\036\f\001\017\b \024\021\ )Tj 0 Tw (-)Tj 0.156 Tw T* (\f\030\024\004\036\027\027\031\033 \030\036\022\024\027\f\021\030\031\022\ \006\017\033 \f\235\017\027\022\021\036\030\027\024-\035\036\r\026\021\024\ \030\027\024\020\024 )Tj 0.018 Tw T* (\022\024\n\023\035\036\022\f\026 \023\024)Tj /Span<>> BDC ( )Tj EMC (\023\024\r\024\007\031 \023\024\f\035\036\030\024\007\024\r\024\005 \026\ \027\026\035\034\027\024\005 \017\027\022\024\027)Tj 0 Tw (-)Tj 0.171 Tw T* (\021\017\027\036\027\006\017\017 \r)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\017\024\007 2019\2262022)Tj /Span<>> BDC ( )Tj EMC (\020\020. \r)Tj /Span<>> BDC ( )Tj EMC (\204\203\210\037 \204\206\211 \017\n. )Tj 0 Tw 0 -1.218 TD (\204.\200. \214\024\n\024\027\024\f\024\r\026.)Tj 0.13 Tw 0 -1.218 TD (\025\030\017\021\036\030\017\017 \r\022\035\033\004\036\027\017\016: \r)Tj /Span<>> BDC ( )Tj EMC (\017\f\f\035\036\007\024\r\026\027\017\017 \023\030\017\027\016\035\017 \ \031\004\026)Tj 0 Tw (-)Tj 0.094 Tw T* (\f\021\017\036 \023\026\006\017\036\027\021\022\017 \f\021\026\030\001\036\ 18 \035\036\021 \f)Tj /Span<>> BDC ( )Tj EMC (\022\035\017\027\017\004\036\f\022\024\005 \022\026\030\021\017)Tj 0 Tw (-)Tj 0.418 Tw T* (\027\024\005 \026\027\026\035\034\027\024\005 \017\027\022\024\027\021\017\ \027\036\027\006\017\017 \030\026\035\017\004\027\024\005 \f\021\036\023\ \036\027\017 )Tj 0.032 Tw T* [(\r\t\030\026\032\036\027\027\024\f\021\017, )0.5(\r\024\027\017\022\001\036\005 \r\f\035\036\007\f\021\r\017\036 \030\024\ \007\024\r\024\005 \021\030\026\r)]TJ 0 Tw (-)Tj 0.097 Tw T* (\n\t \023\030\024\n\036\032\027\024\f\021\017, \022\024\021\024\030\t\036\ \023\036\030\036\027\036\f\035\017 \b\017\030\031\030\020\017\004\036\f\ \022\024\036 )Tj 0.21 Tw 0 -1.218 TD (\035\036\004\036\027\017\036 \r)Tj /Span<>> BDC ( )Tj EMC (\204\203\210\037 \204\206\211 \017\n. \204.\200. \214\024\n\024\027\024\f\ \024\r\026. \025\030\024\n\036 )Tj 0.338 Tw 0 -1.218 TD [(\021\024\020\024, \024\002\016\026\021\036\035\034\027\t\n\017 \022\030\ \017\021\036\030\017\016\n\017 )0.5(\r\022\035\033\004\036\027\017\016 \002\t\035\017 )]TJ 0.032 Tw 0 -1.218 TD [(\023\024\007\021\r\036\030\032\007\036\027\027\t\005 )0.6(\007\026\027\027\t\n\017 )0.5(\031\035\034\021\030\026\r\031\022\024\r\024\020\024 )0.6(\017\f\f\035\036\007\024)]TJ 0 Tw (-)Tj -0.038 Tw T* (\r\026\027\017\016 \007\036\235\036\022\021 \026\023\017\030\026\021\036\ \035\034\027\024\020\024 \026\023\023\026\030\026\021\026 \026\027\026\035\ \034\027\024\020\024 \022\026)Tj 0 Tw (-)Tj -0.016 Tw T* (\027\026\035\026, \f\024\020\035\026\f\017\036 \023\026\006\017\036\027\021\ \024\022 \027\026)Tj /Span<>> BDC ( )Tj EMC (\031\004\026\f\021\017\036 \r)Tj /Span<>> BDC ( )Tj EMC (\017\f\f\035\036\007\024\r\026\027\017\017.)Tj 0.215 Tw T* (\025\030\017\021\036\030\017\017 \017\f\022\035\033\004\036\027\017\016:\ \024\021\022\026 \023\026\006\017\036\027\021\024\022 \024\021 \031\004\ \026\f\021\017\016 )Tj 0.149 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\017\f\f\035\036\007\024\r\026\027\017\017, \024\021\f\031\021\f\021\r\017\ \036 \023\030\017\027\026\022\024\r \235\017\017\004\036\f\022\024\020\ \024 )Tj 0.203 Tw T* (\007\036\235\036\022\021\026 \f\235\017\027\022\021\036\030\027\024\020\024\ \022\024\n\023\035\036\022\f\026, \026\027\026\035\034\027\024\036 \027\ \036\007\036\030)Tj 0 Tw (-)Tj T* (\032\026\027\017\036 \035\033\002\024\005 \007\030\031\020\024\005 \220\021\ \017\024\035\024\020\017\017.)Tj 0.12 Tw T* [(\200\f\036\n \023\026\006\017\036\027\021\022\026\n, \024\002\030\026\021\ \017\r\001\017\n\f\016 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC (\211\027\017\r\036\030\f\017\021\036\021\f\022\031\033 )Tj 0.017 Tw T* (\022\035\017\027\017\022\031 \204\206\211 \017\n. \204.\200. \214\024\n\024\ \027\024\f\024\r\026 \f)Tj /Span<>> BDC ( )Tj EMC (\032\026\035\024\002\026\n\017 \027\026)Tj /Span<>> BDC ( )Tj EMC (\027\036)Tj 0 Tw (-)Tj 0.019 Tw T* (\r\024\n\024\032\027\024\f\021\034 \023\024\035\027\024\006\036\027\027\ \024\020\024 \022\024\027\021\030\024\035\016 \026\027\026\035\034\027\024\ \020\024 \007\036\030)Tj 0 Tw (-)Tj 0.184 Tw T* (\032\026\027\017\016, \023\030\024\r\024\007\017\035\026\f\034 \r\f\036\f\ \021\024\030\024\027\027\016\016 \024\006\036\027\022\026 \026\027\026\021\ \024\n\017)Tj 0 Tw (-)Tj -0.039 Tw T* (\004\036\f\022\024\005 \017)Tj /Span<>> BDC ( )Tj EMC (\235\031\027\022\006\017\024\027\026\035\034\027\024\005 \006\036\035\024\ \f\021\027\024\f\021\017 \f\235\017\027\022\021\036\030\027\024\020\024 \ )Tj 0.167 Tw T* (\022\024\n\023\035\036\022\f\026. \210\006\036\027\022\026 \026\027\026\021\ \024\n\017\004\036\f\022\024\005 \006\036\035\024\f\021\027\024\f\021\017\ \n\t)Tj 0 Tw (-)Tj 0.185 Tw T* (\001\036\004\027\024\020\024 \022\026\030\022\026\f\026 \r\t\023\024\035\ \027\016\035\017\f\034 \r)Tj /Span<>> BDC ( )Tj EMC (\024\021\007\036\035\036\027\017\017 \031\035\034\021\030\026)Tj 0 Tw (-)Tj -0.016 Tw T* (\r\031\022\024\r\024\005 \007\017\026\020\027\024\f\021\017\022\017 \205\ \206\207\211 \253\203\204\222\037 \022\024\035\024\023\030\024\022\021\024\ \035\024\020\017\017 )Tj 0 Tw T* (\017\n\036\027\017 \202.\203. \217\t\032\017\b\273 \204\017\027\007\030\ \026\r\026 \217\024\f\f\017\017 \(\217\017\f.)Tj /Span<>> BDC ( )Tj EMC (1\).)Tj 0.383 Tw T* (\215\030\024\006\036\007\031\030\026 \224\217\211\003\222 \r\t\023\024\035\ \027\016\035\026\f\034 \f)Tj /Span<>> BDC ( )Tj EMC (\017\f\023\024\035\034\024\r\026\027\017\036\n )Tj 0.655 Tw T* (\r\027\031\021\030\017\023\024\035\024\f\021\027\024\020\024 \n\031\035\034\ \021\017\004\026\f\021\024\021\027\024\020\024 \220\027\007\024\030\036\022\ \021\026\035\034)Tj 0 Tw (-)Tj 0.149 Tw T* (\027\024\020\024 \035\017\027\036\005\027\024\020\024 \007\026\021\004\017\ \022\026 8883 \f)Tj /Span<>> BDC ( )Tj EMC (\004\026\f\021\024\021\024\005 4\22612)Tj /Span<>> BDC ( )Tj EMC (\204\206\006, )Tj 0.472 Tw T* (\022\024\021\024\030\026\016 \023\024\r\024\035\016\035\026 \024\006\036\ \027\017\021\034 \f\021\030\031\022\021\031\030\t \026\027\026\035\034\027\ \024\020\024 )Tj 0.153 Tw T* (\022\026\027\026\035\026 \r)Tj /Span<>> BDC ( )Tj EMC (\030\036\032\017\n\026\b \035\017\027\036\005\027\024\020\024 \f\022\026\ \027\017\030\024\r\026\027\017\016 \017)Tj /Span<>> BDC ( )Tj EMC (\021\030\036\b)Tj 0 Tw (-)Tj -0.004 Tw T* (\n\036\030\027\024\005 \026\r\021\024\n\026\021\017\004\036\f\022\024\005\ \030\036\022\024\027\f\021\030\031\022\006\017\017 \017\024\002\030\026\ \032\036\027\017\016 )Tj 0.242 Tw T* (\(\200-\030\036\032\017\n)Tj /Span<>> BDC ( )Tj EMC (\227 \030\036\026\035\034\027\026\016 \r\017\031\026\035\017\026\006\017\ \016 \017\024\002\030\026\032\036\027\017\016, )Tj 0 Tw T* (\217\017\f.)Tj /Span<>> BDC ( )Tj EMC (2\).)Tj 0.108 Tw T* (\215\030\017 \224\217\211\003\222 \r)Tj /Span<>> BDC ( )Tj EMC (\030\036\032\017\n\036 \030\036\026\035\034\027\024\020\024 \f\022\026\027\ \017\030\024\r\026\027\017\016 \r)Tj /Span<>> BDC ( )Tj EMC (\023\024)Tj 0 Tw (-)Tj 0.031 Tw T* (\022\024\036, \002\036 \r\024\035\036\r\t\b \f\024\022\030\026\013\036\027\ \017\005, \024\006\036\027\017\r\026\035\017 \f\035\036\007\031\033\013\017\ \036 )Tj 0.233 Tw T* [(\023\026\030\026\n\036\021\030\t: \021\024\035\013\017\027\031 )0.5(\f\021\036\027\022\017 \027\017\032\027\036\026\n\023\031\035\016\030\027\ \024\020\024 )0.5(\024\021)]TJ 0 Tw (-)Tj 0.007 Tw T* (\007\036\035\026 \023\030\016\n\024\005 \022\017\001\022\017, \b\017\030\ \031\030\020\017\004\036\f\022\031\033 \017)Tj /Span<>> BDC ( )Tj EMC (\026\027\026\021\024\n\017\004\036\f\022\031\033 )Tj 0.084 Tw T* (\007\035\017\027\031 \026\027\026\035\034\027\024\020\024 \022\026\027\026\ \035\026; \021\024\035\013\017\027\031 \017)Tj /Span<>> BDC ( )Tj EMC (\006\036\035\024\f\021\027\024\f\021\034 \027\026)Tj 0 Tw (-)Tj 0.251 Tw T* [(\030\031\032\027\024\020\024 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC [(\r\027\031\021\030\036\027\027\036\020\024 )0.5(\f\235\017\027\022\021\036\030\026; )0.5(\021\024\035\013\017\027\031 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC (\006\036)Tj 0 Tw (-)Tj 0.252 Tw T* (\035\024\f\021\027\024\f\021\034 \035\036\r\024\005 \017)Tj /Span<>> BDC ( )Tj EMC [(\023\030\026\r\024\005 \027\024\032\022\017/\023\031\004\022\026 m. lev)-15(a)15(t)17(or )]TJ 0.146 Tw T* [(ani, )0.5(\026)]TJ /Span<>> BDC ( )Tj EMC [(\021\026\022\032\036 )0.5(\031\020\024\035 \017\b )0.5(\r\023\035\036\021\036\027\017\016 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC [(\023\030\024\007\024\035\034\027\031\033 )0.5(\n\t\001)]TJ 0 Tw (-)Tj 0.302 Tw T* (\006\031 \026\027\026\035\034\027\024\020\024 \022\026\027\026\035\026, \ \006\036\035\024\f\021\027\024\f\021\034 \030\036\022\021\024-\r\026\020\ \017\027\026\035\034)Tj 0 Tw (-)Tj 0.179 Tw T* (\027\024\005 \023\036\030\036\020\024\030\024\007\022\017 \(\217\200\221\ \), \030\026\n\036\030 \007\036\235\036\022\021\026 \027\026\030\031\032\ \027\024\020\024 )Tj 0.226 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\r\027\031\021\030\036\027\027\036\020\024 \f\235\017\027\022\021\036\030\ \026 \(\217\017\f.)Tj /Span<>> BDC ( )Tj EMC (3\). \212\035\016 \017\n\036\030\036\027\017\016 )Tj 0.357 Tw T* (\023\030\024\021\016\032\036\027\027\024\f\021\017 \007\036\235\036\022\021\ \026 \024\006\036\027\017\r\026\035\f\016 \031\020\024\035 \007\036\235\036\ \022\021\026 )Tj 0.103 Tw T* (\n\t\001\036\004\027\024\020\024 \022\026\030\022\026\f\026 \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\026\007\031\f\026\b. \211\004\026\f\021\024\022 \024\022\030\031\ \032\027\024\f\021\017 )Tj -0.009 Tw T* (\026\027\026\035\034\027\024\020\024 \022\026\027\026\035\026, \030\026\r\ \027\t\005 \024\007\027\024\n\031 \004\026\f\031 \031\f\035\024\r\027\024\ \020\024 \006\017)Tj 0 Tw (-)Tj 0.066 Tw T* (\235\036\030\002\035\026\021\026, \f\024\024\021\r\036\021\f\021\r\031\036\ \021 30)Tj 0 Tw (\260)Tj 0.066 Tw (. \203\026\023\030\017\n\036\030, \007\036\235\036\022\021 \f)Tj /Span<>> BDC ( )Tj EMC (11 )Tj 0 Tw T* (\007\024)Tj /Span<>> BDC ( )Tj EMC (2 \004 \023\024)Tj /Span<>> BDC ( )Tj EMC (\031\f\035\024\r\027\024\n\031 \006\017\235\036\030\002\035\026\021\031 \ \f\024\024\021\r\036\021\f\021\r\031\036\021 90)Tj (\260)Tj (.)Tj 0.014 Tw 23.244 64.543 Td (\215\030\017 \023\030\024\r\036\007\036\027\017\017 \023\030\024\002 \f)Tj /Span<>> BDC ( )Tj EMC (\027\026\021\031\032\017\r\026\027\017\036\n \017)Tj /Span<>> BDC ( )Tj EMC (\r\024\035\036\r\t\n \f\024)Tj 0 Tw (-)Tj 0.218 Tw T* [(\022\030\026\013\036\027\017\036\n \026\027\031\f\026 \(\023\030\024\002\ \026 \200\026\035\034\f\026\035\034\r\t\) )0.5(\024\006\036\027\017\r\026\035\017\f\034 )]TJ 0.118 Tw T* [(\f\035\036\007\031\033\013\017\036 \023\024\022\026\026\021\036\035\017\ : )0.5(\026\n\023\035\017\021\031\007\026 \023\024\007\r\017\032\027\024\f\021\017\ \023\031)]TJ 0 Tw (-)Tj 0.147 Tw T* (\002\024\030\036\022\021\026\035\034\027\024\005 \n\t\001\006\t, \f\021\036\ \023\036\027\034 \f\n\036\013\036\027\017\016 \r\035\026\020\026\035\017\ \013\026 )Tj 0.112 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\n\024\004\036\r\024\020\024 \023\031\t\030\016 \r)Tj /Span<>> BDC ( )Tj EMC (\007\017\f\021\026\035\034\027\024\n \027\026\023\030\026\r\035\036\027\017\ \017, \023\030\024)Tj 0 Tw (-)Tj 0.308 Tw T* (\035\026\002\017\030\024\r\026\027\017\036 \f\021\036\027\022\017 \023\030\ \016\n\024\005 \022\017\001\022\017 \r\024 \r\035\026\020\026\035\017\013\ \036, )Tj 0 Tw 0 -1.218 TD (\f\017\n\023\021\024\n \r\027\031\021\030\036\027\027\036\005 \017\027\r\ \026\020\017\027\026\006\017\017 \023\030\016\n\024\005 \022\017\001\022\ \017.)Tj 0.131 Tw 0 -1.218 TD (\212\026\035\036\036, \027\036 \r\t\027\017\n\026\016 \007\026\021\004\017\ \022 \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\f\r\036\021\026 \022\017\001\022\017, \r)Tj /Span<>> BDC ( )Tj EMC (\021\036)Tj 0 Tw (-)Tj 0.255 Tw T* (\004\036\027\017\036 60 \f\036\022\031\027\007 \023\030\024\r\024\007\017\ \035\026\f\034 \006\017\030\022\031\035\016\030\027\026\016 \026\023\017\ \f\034 )Tj 0.111 Tw T* (\026\027\026\035\034\027\024\020\024 \022\026\027\026\035\026 \f)Tj /Span<>> BDC ( )Tj EMC (\017\f\023\024\035\034\024\r\026\027\017\036\n \023\024\f\035\036\007\024\ \r\026\021\036\035\034)Tj 0 Tw (-)Tj 0.086 Tw T* (\027\t\b \021\030\026\027\f\022\024\030\024\027\026\030\027\t\b/\035\017\ \027\036\005\027\t\b \007\r\031\b\n\036\030\027\t\b \f\030\036\024\r )Tj 0.139 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC 1.345 0 Td [(\030\026\f\f\021\024\016\027\017\017 )0.6(65 )0.5(\n\n )0.5(\(\024\021 )0.6(240 )0.5(\007\024)]TJ /Span<>> BDC ( )Tj EMC 12.854 0 Td [(300\) )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC 3.05 0 Td (\017\027\021\036\030\r\026\035\024\n )Tj 0.124 Tw -17.249 -1.218 Td (\f\022\026\027\017\030\024\r\026\027\017\016 0,15 \n\n, \004\021\024 \024\ \002\036\f\023\036\004\017\r\026\035\024 \023\024\035\031\004\036\027\017\ \036 )Tj 0.004 Tw 0 -1.218 TD (\024\002\255\036\n\027\024\020\024 \021\030\036\b\n\036\030\027\024\020\024\ \n\026\f\f\017\r\026 \017\024\002\030\026\032\036\027\017\016. \003\026\ \021\036\n )Tj ET q /GS0 gs 195.5905594 0 0 260.867404 274.9606323 290.4126253 cm /Im0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.254 Tw 9 0 0 9 274.9606 279.5445 Tm [(\022\t\217\210\b\002\220 )0.6(1.)]TJ 0 0 0 1 k /GS1 gs /T1_3 1 Tf [( )0.5(\214\023\022\024\032\026\016\027\205\013\n\027\n\017 )0.5(\026\033\033\026\032\026\024 )0.6(Flex )0.5(Focus )0.6(500 )0.5(BK )]TJ 0 Tw 0 -1.2 TD (Medical \(\200\026\021\025\002\))Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf -0.015 Tw T* [(F)-16(igure 1)47(.)]TJ 0 0 0 1 k /GS1 gs /T1_3 1 Tf [( Ultrasound machine Fle)-15(x F)11.9(ocus 500 BK Medical \(Den)]TJ 0 Tw (-)Tj T* (mark\))Tj ET q 274.961 122.596 221.102 114.044 re W n q /GS0 gs 221.1023816 0 0 114.0446519 274.9606344 122.595841 cm /Im1 Do Q Q BT 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf -0.033 Tw 9 0 0 9 274.9606 111.7959 Tm (\022\t\217\210\b\002\220 2.)Tj 0 0 0 1 k /GS1 gs /T1_3 1 Tf ( \216\021\205\024\032\025\033\n\023\n\t\024\021\n\017 \003\205\023\022\024\ \025\006\026\t\024\n\024\021\020\017 \r\021\030\n\032\031\013)Tj 0 Tw (-)Tj T* (\024\026\023\022\021\020\017 \023\025\021\031\017\021\020\017 \030\026\024\ \006\025\013 \t)Tj /Span<>> BDC ( )Tj EMC (\006\026\t\024\n\024\n\017 4\22612)Tj /Span<>> BDC ( )Tj EMC (\240\210\203 \(8883\))Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.002 Tw T* [(F)-16(igure 2)16(.)]TJ 0 0 0 1 k /GS1 gs /T1_3 1 Tf [( Intracavitar)-42.9(y multifreq)14.1(uency endorectal linear trans)]TJ 0 Tw (-)Tj T* [(ducer with a freq)14.2(uency of 4\22612)]TJ /Span<>> BDC ( )Tj EMC (MHz \(8883\))Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\033\030\031\030\213\b)-20.9(\035\231\213\233\t \021\032)50(\b)42(\032\231\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj /T1_4 1 Tf 25 0 0 25 512.8768 56.0378 Tm (73)Tj ET endstream endobj 1854 0 obj <>stream Adobed     '$''''$25552;;;;;;;;;;   ####''',,,   ####''',,,   ####''',,,""   {!1AQaq"2B#RSbr $%&'()*3456789:CDEFGHIJTUVWXYZcdefghijstuvwxyz!1AQaq"BR2Cb #$%&'()*3456789:DEFGHIJSTUVWXYZcdefghijrstuvwxyz?ԊRj^MR]Sd ߽/(km-( JWb$^GRRK J8='2(+9^ ]RϷE.EwPl#JkÄ387Pb&tEϟ<sdz+ مѱa;{\uy[ʶKɉ0}oR(ho`^8϶H*i8Vh9K[P!.EPB T"@LHRZKbPB*T#B@DJ(8.z7y:ET= J8/ ,ͷQ7ElQsAI)ӮWv)`.K̄x]tp hz Q̎4RIi ٪UF!ҩD|W̕/es*,-S3m}6Y-#d'UYNDž=kL)1NuQ{iyT}Q=›wn ы^$bcSbќŭ<{p-U>ޕj+rD;U ٘GaerGZKu-\m|>6C¦u>vGxUޕ,^.aS_+[dl7eU FJnL"7vbwJwW= ;el^p{rŶS3ʕbͫîZf8ﮍrWur83BYcUħ85F3TjZzНҽzBv"N"7qYcmI0uL^T2Uջ's]%5@ݹ&( 8pҀJ^{4u7u @6֑gl),\BYjWiO"d;M^8N˩eI,&e4NQȚHtṿQ;9檨myPSsBB/I HBUE}E3LO3zҽuunem箪2{obuB'Q[M˅W"'K__,:*n^7eyvn̞X/7ǃcw~91Tv Wt]3]2k\evK$wW-tT(^p|o' 8+-/saj)i2+vW+m;X^o&u8gTnܘq}tޙ ^ޢ;10k]X_ҸD&ȼ?24~oB@!@!!@Bgz!^,ɍ6 6FWfS=<.;.$ī`ŝ$®zˎ՝Uq= !q2H] TiXLN竕@*"8. ko4b"g{Fgba1ٹbrTY3FQ)Ō59~m[;3VBA9)%B[r]kנId*pК^/D@j؀>X{/e;#<\W,6=i5#'SRa뗕=aJK$ tTN`tЎk*B'I,< +=#}vE6xM"W ҍBp5n#UAGJNߥ6 )l֒w,]-mOV[)X"xZԃnn짴YV:G$_)g,l,-/}qqtՍ=isCnȯqn^誺8bPX;(9QPt>5>ƁΎ3<{BdO,Fȭ\,K]ҩs%.Rn 9x4[\RW Ki=eao@`,;ȝ F9ċ:"WEWJ-~L XV#ʪR)[T֞UNHoz ͆qaUZ{a,>"j{OI}1zOBL %BYC{!JS洴aVtB/Q^!<tɄCЕA Py~sD8cCQvnjQzyʵvRв0kx_býu̫QҎ d8С˧sȝKym^m:N< ~)lz! &`BB=wPPPzkIKTr%XE/K!׉Y !¨4O,fbqX1xQbibw3SKV}SOFrS.[6 9*S<К*M.~V=O"5;9o/gCF5Z[=1F SU&.Vܔ;T,iPdh[Jmð"Og>ANSBR}= GY :u hˆ@'M']Y@T$ 10 &sԖxHLpK%)7(bnB:77cIx^ "B҉wu"RAAyF 0LmRbI; ]#P t_m6#f-^cN4"7YTt#@ۣ #TM x#J^4eR5Y*@,N( (lR4!ʎVf- ⎲9$pI,W .F̠4{! ΐ"'.)*ʘy{/փ! 4o6.DWVN`whpӡ$쮢iX ,7v XZqK<|EPMʒuӼG]-;RӔR'JX7PfqI)Q#zGOD'lЄs ˜&s+j+zmXCGr{i= wf,w>\MSDSLxvn!th0sX]]&\K ݶ% U;=YH `KZt=; lJL(yaU^,y06ab|zEԍ]jƽ;ï}f4jĚo"tkZB-W. <;n<{~Le-Ԟx5o#*ptm&?Ծ я'{^t숈vg $6TI lO'3øwb)S+]΋Eiƫw,[8bi֝5"3j ?⚣("'D#\'E@`w,e%/11>i *{Ь5ɢ+<<0O*PSWpGٺېuV Vчڻ-]!:#Zl&JS69^dLK8Q6mxgSvՁh蚢'FO-Ş7=4^%UU5EZ;T4! ׯΗBB׀H"Cz="T$,!1O{N$I6 xĞ.+PZO]RW͆ [ie5afJ7.kS[T8{TkVak?fn:scͷD#ȟJEzʪ-k|JjI#:aUVHsun8L[oC{1;Z^ꦭܴ?emnOM.rn^bF&8IE7l/3lyzH`UVh2u>$m%_֛M;12^&[:Z8ۣp8MsN :(5SE13D^"#+{+G+\FdU>LC5Tӽo>7uب:10Hxv7%ULUV533Q;>Gtg#ywa`ms=Đwr/)Fz<\ܓ}́>a:ݸ; ́FZ}nh'MLr6$\C߼جt{% F<)tΫ:R{fYA=ƝMOu0#>ThWpdd"Ct<# u]M墊}kL"~uqMB#!ȇ :xK CubN$lVeK=ĝMN19iARϻDbo~fjhC`x4'2b5IJmeb[SZvK dx{K#L17~:ǟo'L8ƻV#ř"v.o\=]caVN.rOMk{s=хкFB׌Ln)!.n{ILT4rsu9XUEtWhLENɆ5WT?ZmmvXĜ%[ȁV`L/N>;;YƨDBkm6}L&[ŇTn|;Fծf{Ff3GR4LShKRʍ=ev63(6COu<!TN:=sut_?=ISc=HӶki%̈zb2 a+תyGuyj#N%ORXR=wiz=Nҍ{"׬(y^OBzoGui8|Ӊnay;kݔZapx"ו'wcOa˽Xyz_+;dC]]瀎jNb펃X׹a"qZ%;8l~F:uksGIsԞ&xRTEYrqg+){$1+V2,yM !yO:sԤvv3Ԟ]WĞWEіOCd-7 nC 8|Y}O/'YTӶK 'pdlGCdy 駩[uz0ORaՁpWcb[{e]V'lӻcίK'|mz(. ^tJ628:<~gM:R[ziF Adhݑ@2k 7`y' iKtU]8ؔSVVu{U4՜Ec@I2&ӓ<\R?dr962KYg\ч1;9CmOQ9h%-5,xbmAJmF wAc@9Nst.rRSiӫDZ;Tu٪ç c):xijTu8Q5^"Lhʕ"T$B\x= Ag"1UD(Db>RΩQE5-a$ayOv\xkLor_4]ᛸ98153>$9n⌅ 6 T\ 1xQh4_-zt[)FՠjSUɭDCPIF{&jZw3:YW9HGT둰*^UETlcgwK [ bIF͆=[*6ÈWhQyBL* o"AEUzPj'*#XEۂ4tHӅ h jhQ NXzud Q^HΝ']D\b8RNKؗYolol:CSzֽJ'e$RToj'1, 7MDf'd= :`0АA=x n5}nZZF0K:'B`yK6k(bVh$'tg]&m+[Q0%)h׊lƱ~uNzBlqa2<  eL d7νeӱ3|oXpܣ)$K: DMWNbM7SǜNꢞ,SK՜>wF蘍Ѻ7.-U5hKnw4U\S|STlS gqutbny*ƙ10e_+Kom%`F˧6QXJnUUl8PkDgSU4Uof.&j{7ۗXщTͦ应˼8sWjyoپHzMb6ge.;QԢt X¢4De=G.k.4"/6l*vsN=Cxz%FèN:ܳ6:#}_4kbEւ\e` A+tf!@Hҫ߲p!e8o !2lC gPMę&)ffhDNꈦ =JT7U{bg =;UU2D)N&7Q[ӉbDLDj}u1FkSMSNwæ)gT:/g krp[tgZ܅ecvC`:dbI]v\霟$auǍ\9X$(ׯ7쎂pSubn<;n=5Uc_(k6|>쮬Z ws][mS|t> pP}GDWz.=:pQ?A#D^b׽Qw =h413 '"b#xDG$B9ėu8nG_QwnNQU|-Q,:5~mV}_0p7q7YMeqZ ]t7z vuRHgjlj:G^nܰ$%E%oXxu%ytp[`5bŠد'4mSM@;ԃ=fWO0ˢ5M^w6}Op?͉L{fkrՉU4NtaQ\Q1}Ӂ:&x:Kn&JwVk磬^bD6C cȯΛk*e,a"EDyNVqgNT5FDr1>?~p׃Ü9bQE1fgEUDN;0?rQ«FÊΫMKpƊb&ܶue4LbGF)t$v.etR8KcԄaZfH:C8JHr" ntV0hj4w'EVzKqA+wբu1^rDq:5DD1LDt$Bsa MwUgfG܆ Qgje46t)i¦8MܘT^隦g,*bff&"b5^hƧ[yM4xӿh1:xUSEqMќ$wuOe\Z%ոnOHȲș$v(cW^}TGiVtlfiZp⚷6,LZF4D)xvt*O*!y%"+\& ɆUvnD.*NDqavqdGmn8Jc = _ U7ќNKx|.x8abE8%:jՍω{U1vYDn8{b+=DnYĜ[_{;#ms҃ Io\.125s6oe7McD ĚHjR@U⺨aR0\\k=ͱO'2o1j;)eܘTSNu`Uz1jPِe3,Xa\0ܨ=s^[@nQaΫE1v_"y6ȩįr22}}NzSETZ8XD5S3eU(:qb(oTDLL]uE9Ufa.{)TClvm6\۲WIJ릙#DU1⺵Rm6cCtcF-s6pϲj: 2|64>WIy0HHNZd ԪLfvDZ-=InVĪbf͢6BٙahJ%Ԧ P۩8b;dzzzQqIpbz@Z%-ڢW@Y+79!2 Q9ׂēgrJs Hq^␑ I(@q084UzqC48d=иS".Ѿf%e7h62ۢvt['o5n |=rx{۸+=8REJnaxK^h(/57"} ԧR/ւk;q;|EPr|)hԂO/ ^o{^nRݿ,MBI~[^p&T q!۷_==k>84:m8" %3k2Du54TrK3ؕ`ab3LTO%Q7w(&Q)QڸL]L~{ϲqOjNrXlv3sc 10w x{qfgf^oGgCt kԍ]jnjJѣRu6:3H,h#\88Q. 7Jji^jZE1isMUTw7 7ޛ7F51uN0'sgkWzSwEUMDxBL>YtIRa2-+8_iE]3ESMZb[ ~9ţ}Lߢb.-u@ %f= O0nU@+,Ψy2^阼QIZav{' ȬcZ$3T1d\#p j;+L +UxQSye;tщ]3^:㻣9%. fֽ\^%PxBSdA{[ cI8vh^\>BU3UsjgNzn\ ]׃|1ثĈ쩪9448qĈeU5T׉꫙UEke^UW^-3:/:x,l-ڡa9U*;)&N!k^$d*ʼՍg{8qM=í*E8U{dqMusTӨ.hvaW3T[+Ӝjک=InhuN\ =Gn ZXb:S,,]О"4 Z&3Z67̈́'$ Fۙ.T{d(Q*v n覜xWSU{:"L߲?SM(E꘯.,v/-"ݪ4%&^*$7qfĬ`FCt<nuwJdXM ڲ\ҼtQUxM H(x^0tbصS/NNX[:8y{,{Z<7bp_*z]6ĎژĽM8Lgz%LYMHǃtޥisUTɩv`ZfqΞį*Z{V .G*7%#)3xHSʾaf9¦6Q> ߸ qh_{yΩj۟T>jF]2Eú?^%Cpahgsզ'/lGS8<Nv0FܹﰫӪ6Rdb${%Bn ]NJJ\0 4GG>ԲX5Epv7][XLXbLѝ5հޕnM mRmIko/ҸrtR D缂g z 0bInL& ex^&WZLh(vpdrI;&*tX 6Ϣ$٥ 9:Ƥv׃2b0 Ɗd2WM1` ]L $˄PAN iQ+DvʘME{ucmV Pͻ' }3P/hTɇ =QfWp*^FtnZ=j㗦Lӡ-5E\Є)U"iQ!z!@ӟݦ r޹^h"NKe/7 Mvȋza6z⇚sLw;y::?e*\ȶN,30ލB Xo &ɍd]%bYihC:&SbuDtc$UW4t_}LnEģO^{"n5q-ET3xI\ØƢ#\E9lzDnctWTJׇ)h#.fA 67+ɚ 8i^g8,װΫS{eZ#4OHr=٢km0UYe1:&7U;٘NU;M8{oLz4wS=DuF$x4o徦y*8k$54"@XP ^,޵ 8@{)|v{C#jh P6I?hx4'Io% vvpm.66vR4\kay$@)#Y)f%w nO7(i fh+X2jm|aQ;E\^'.J>O2]UuLH"nA!@G<4Lٍs5^(W6O66fe&mdnfF^Ze Uvf_cN")cH!>,";4F3â81B 9v([D ؘfӜ쁕6д(d<#LA ceɶE93@IydG{dd^30BӢwLH%x40fujd=-cΕuձ6O%5,>l~(DvHT628 ,{4t ,km,xhSf"wZgGi~.68*fkjmtSKq` ÎI=!07XBC +]**f4R%VAߓgeG0 o[mfQ Go ,, TXuRqHm%܋ChsLBEB$xPHtWd ҄!Ld;uх4 N2ݦ17TYfM@<Ъʻ)B{Y&xm\#lO``"B,xSL·}σS\F74Nct9s"Ar &YMx{ 'My|&̛gK !)ZeuULLƭU٘Ί*SVnLy-4~K>R̤:C5iQ2?q[LxpNԍɲG} 8;4̳!qYDŧ}9LMtF[g6ʨUQKykޘDbΘR4HۍJlX ^ *:Y;~reP a F{NB،9Ӧ-ʊNyTf.Uw,%siDTmUO{eL+=7c<9ٳ&)*f V>sb72kOM[I^35E6Xw"zy1[ë́;1faDa@A2$h6a kee$'8Uͭvua3{E`n2M3~&6iӇ_LB,ic^PdP2(4C&g9+Y+ ̒%UAFV/bfLƸe^.&'sU\2ErycI."RɊdN h.{c^M#4 k[`PM Ϋ l [3A(82[[aASacS=">Sk^*jy6$$SOb2~w b ;\77kk*jL&QW+"JfP^!o [ȧ$W׏ؒ҉iK4Mՙʖ_ȉ*,ϣy)v9sInsq¦TZ˪ϳ죷gvE$=Fk{yn_,rn(i_(iy#9i}r=t#է]e')7I9xg[Ў=4&zAG;wgoS.omqep ig4G睼ݻH{e.[îiT ^à+ai5I Xg8ԸQz1#'½KD6^#37EtlxuS31Dvu*ŧ8s{rk'vF tE8u:] :]иBtZ :r[Kҋj<4_dn{.ѫW=y3|J{Gxs23 97*7 n, V 'h'w ELn-834*Xw=螷Oqܕn-^ Yf*8b]NZn~4ZNq5ͽk1+nFs5i3clF\֒2.R<|hNdgRaO"F9\k2 N1 \&W֕պ)0WdS32;GNnqh—p"D$qzq2/2cU1:pʚbf,4363:Y 2\lv憐)bC l3"w'xPsEq+FY+;H fkT(xUg!lO `k`KقH/lL R$ϙ"DIٳjyhp!`6(׸`< D F "HED-s&҂w9SlZdr3Z!7ZY)aCȂc}g1MQ5F"s3ͧh8v׶ap $Ire$ȍaGvĽDL" &Ǿm#"ؓU31Z"ݔEG MQkߡ5 P5dFqs\$ZjYؾӣBeMZKآ$>ɲGXKkMn:kšMxĴվ&xz{&eWZI^%֍kЂ ֖*')8)y 7>҇ۧC,|wҀmT vD츾/0j򈞍"Kn| эG.6XCHjDc%hph$#{V1s9V&ëNooRWUOjè6Io|L*kioh)_ɮ+P&11TF׺QiUWsN;\M3עbWMMȪ8, wM af-"ա^s9sms2-2ޒd9Hʲv[*"m38R7&誚&UUDeYOh8Q}qwPѺpcbDM1+%135D>&bd$T, "IP$%BpL,{OH[:]@ PBBKL'W Ը_f8tk1ɶKK(Μ fMtHm%z .G8e{2kB;|%ry<LFCMM.ce3>xQ2¬X3ʣ3FS cUIh1 ݈c̪&Pb8X $Vė88;LfN7\霈#B\\H*z(B@1C؇ؽRRSHח(vM~,TLMu!Cs$v9o')4jSɔK،=q\f"92F4ڦ)sI8yak}= eh)pakQX)v̋- ^_vj7;!L }͍^-QM,zh .:d)G"@̂X}YsR'ޠ&{ c Q3qu-LN,Q{č7h*Ū*ÜJ&ggܵE/f=k9rL*]EsKIn)p[LjLmL)y hO<>򢹎Zn~Ʈ:KU8aGu0ʨJwtYfgTK\EX(k*Tp],n8μIL[(>{x=5k;B~Mkv.\ot$xAXfP@ɫ*KeYԖ%%U;)"0Bd*ݮiRDbaU3xHe! <usQclE T(D!RFF7M|~Kpn"Zp+yOFty5.GY$㮲1vF跽rE,87;*hHɪf\aW:ʒU[gj0/6d^Wzݸ0#m}gueΈSRzj60y5 If20ʱFūLoyg(hiZ/n5;Y>b8lji7ћ6{{p=5bUrCD]?-'H9mXvg4h˷G=!'q_'x^Qs(up"wXyos|[ jZ" hE>]|o؋9e^M ^*5I]1 ,f7.o؞ܶWN5i7 gQ}[i*tL+r(8ug ) ؂sSnlSU17/8/"oOfۺ=mO=45Ukq13jm7NLLIjcNY_\%;`i{`U]fm*نv;Hjaj⩙o3y7bQ)O x0eE!85GsNSb4"~9o[ActX5@ryiTUun)ªpbc{# 4i:asQh7oL٩ؒgZq&O.K9<޾rw5qy|M}\eU8cMؐ&-tP#S* O]s~U 6s&/n;YpU:b{9mNUͩfvD]{=ݺ(-zjbi{$tX3eq1o.XĕfP7hfLieg)q7릜]֦/4aUTDs>r u>8,ŝt2eWL19{fIҧ53^WEĹuE7QjnWSܸX1DF'bNwՁSU㘏9L1UsvSFs]n@3l*LH銩cNo)Si *}1M/kFv[lj'x|,T[u%N-5G_8W&>qn$. h[UCt7p^\LY"1^J =MѬ|h`! h*{v69MtO UqDg6:0X(UuD$Ċik{7zӞd'9̅s[W yR XyNWlu Ōoߧ5ME]kGF}W\e6*bSLՕ1yg&TQDi,i(4SOr3)RyKg=EsmZe9]{|FY 'mVGFطCn.$G9>!fݾ]¡$v9x1o6qף_1;wx4OkOM9O7+k#gwQeR#Z[x_.nvg CϑQ;}>ɔv|\&B{2tlOnxy39]afPtla6U|>J|Q4s{1-77mEԞ L6:r>b= }oUݲM>R`3V8jiW>^.4U6yseTF[,j-UZ'.v^Rґ+-*8gVЏuφtr:tvH_rQ=m]٫$n V.uw+Q JJB)KZ)pmh֣;օ'(醥>iIΖ(*~9ugl۞;xg=OپQث CQɱESw'f[Jomܸsϓ54=ALJI῝IvU6ud.+:DqLOA3n s1":%ŒDZ10骪1'Z}m)W(򧳄zQQMi6wW5UMSC{VѢNgM4SixyCFuWB4VTƸIU1TZbEQTog\ *tjXu"qS'Wb XX0U^U:a6රvF5_4qpMy:5keVYYF%XUET͛ ,zqӔ! =1aM,-Ʈі-{=*;+Wt=+]$5S[ܽ0"e35ˣ_%^+MK:Se,pM311k)DRӋ4K,) ӹ[LZl1V#1€4^Jv7΢s߃w[a6[ _]5Kۢih+UDu꼧9<*jl\ѷD/7DgGI˻aCѴ6+ 2:\<<:)WSŒ:'4rU7ou`5`g:{*Ī♌S~Bݭ>qF_ oFH]~Y4AI&gȃ<#DjrQG[meLloq1sxzhmDOg轟tȎmcxx$RJF鳈ȏޙgnidQ0䱩>0tUgmE/olN 1grkV/WD{nnbԽzd TGhM'nZUv,:g`U]JuQ3*T;#-vZ}KꮞAҐecƔH\9geLuXjɖzܭN.uNMN!94%YRƥzѤ8Թf;:(ƥr{7 bzzqx(xe3h;g]#þ$YPpsTL9e]#u]kk+WkQbxŶqZ} k:uS^&$ogўmZ B́ZCʴG@344,EETj'8QV5W;4ﳾQ}9'F5X^%sz>q-ɉG/3iIzriF,NrM6{Q79x-p7M-hxWf2mC5iQkZ0mU 8ۏvv{ڦ. ylqcѾ8okDcZLʮZh\kl# Jj7aMSD5ju\J#Uqbs;OwUյ:IC4Xo.&F.Zo:ќ̬贒8)8q2jkuSMa63`ZxSc3g;( Y 樂Q+Wyu5Ԯ.f'VsuQ;U,dBȎ̳jp"3,ڜa4y0?r)ڨ$|=4/gGoElBDx[eݾRcrtJ'A%G}؎~! D^{-$("|A}r#|[ygS(mZȐrBk,ReͳFeNs&hOE`&hŻ8nޕXo[؝4kC}ʾ/UQ{ĩ>Ss^̓h5x:O$D:ehax"`XKQfBʟUVDuaS8GF{+MF窊DgUd>vn-ɇbMfh״4JD4SKgԬETk[MZ+T=j/64L*"Rn|*'}x\|Ow~4n§}SVYNYzhxk'UyME1>#e->%xtGZ#O1]`ПgMs}x0$;'E,DYZDU5bUꙫCԜFŢ}n87z#-wR;U1MT)]@O ;*ĪbUvKUY+9yLfT{wWyH:R"f2+E1'K źğL7/pǐ^>+=K/7oxq=jGkF‚bX-+F5D%7Ɗ43e檢uDeIԇR8[LN%}F9↯rnl|xJ樯}xYѡJcnVǪ9lLlozaZ>)Ms&(dT՞'T2ov.5TU3U]9'E-&vM^ _378}E7&vt ;E qkw i:}Mj=ƧV/^nM)"T*K/k7zD* Xg'$1vt r`NKJoxWT^8낦Dج0cE31i51L/fTUi;guDdѲ#FZźctaʨ*X|V:fɅ]:js+]e8QZfaF HULi ǦgNpΜx,싘 p]200t%RqlZl;2aVsx4")|F« v%[Υ&oY窦iEC &<cri-n*CQiBN&TZUhҵE &@`7.op={!M71)HbSdazg9%DNzU|Fvs:$HHM1/^LvLDJJpe1g.yޒ| L;ɎE7|8ªXDj,I[jDM%TMu\Q8G4n9ݽ1-q+g gR3Tvfpm1F}]i.uxXq5ӇL'ƫ8ÊcuN禌-b5Uf&i{h8PX!6ҤW4ŦK2 #LE3 VDȔ!yLMt r[ʅUq8DT4MӖP>w$uStWoqDqUZnz4nzqfsQ5EorWpSZ^3_мaIj3s֮.M,~dsFܘ1MFiR4`n0bo\aiS:8Wz8tTf+f16hVݻݘM{4"';_I@bHX;_BW ]ŞDuіLՉ=VZWw=x)щjj&mEv]Yca`D'S*wͫL3˾5|2Lˉ'MWf2tQSTQٴgQ-Xo4[vE4;(æE;}k՚Úܹ# Оҭ UU!͝ydd)SMJ!K:i5D)8b*I%7a9.\,Npҧ,Gu'?Px[tͩ{Lw5UMSjiRL7U[tMQDw-j>usQpXxQ|~b8ΨQ9q#=,pX$.3Xw 2)f%x;ckzÌ;Dq O49h t^-4k/nLeSraW4DΜ'CSFlkA`Lg^w0Hnq#jyDM 9î-3CE1l<ښ7=]}Ӊ7%sF-ubFhp*âS;f-qiiwF4bU]:+>9UCb=ΎN.ܑ;؞Oʛ6GD.>Ms\MYmyDPњsz k+\lIv/E8*sETU3*ZSy(IcdLZݍLĮwS{͙<cpfZD(/-Jm1O6e0|(&Oiu3@M?m29,qLlYхTWކ3917^>]F|l6RjN_oeh4VCr 9əQ2#9[K3&fZg%Q4ע&f&&ӣKT_[qn*͉k7;c,c}HnyXыUQjb"flf.UaaܵӉ\NqgLow1hqܶm+mk[q{̔e^;(#>ɶ!-N —%s紈sKuM)oi{4ݽID¿{-q;xNkæܴSEXo39a*պwLoi8g-q1^gtiN5DLLﯖSI rXPs6 .χLzut#kf$hN/!3k+YM+laUOe=5YnLtWUh ̉9cd'H ،lU!q6d(ma9䴺 WZ)ײC#X=Hu/}NLڙŮ/h|>(}GRSWQ}GZb"z|YjwD[T9>BDND?!dAE,+β{/ %uC ZNH+ 46L*fb9q&7ۛyNظo)7}UMSq8EToj'}MwLN7Vg)76&&fgc 2Jlsc08cУDFIif;u;Q[rVQToaQopf.qn5ӉѢdSԖ6NM.TPM Mab0TPՅTgnjqxEv"kųji'%bS|j,nj91:t+Q] ȍݯc+:f5EYgMvŠ+&'6-Fm11vݬSig3h1`s]4iXU |(j=ؘXxƫFDw (0}j!{D(vF.d'NbnS!:"tެhDwnF$DVUoy_-XXxZ#U37_Y!#ranwLxѕUex:8kwcN;vU*"uS3jok:13, 1R+!`Q6g]Ņt꺋fc]󻖜mV (uƍ㵰ܚRj!aS4LƆ7f56(Ѣ0zر^ 6ydym]c8[zaUA\ofTEqx褣*b'S]*Ύ)tkj-\JbV.tDEV6Zd(͈%}uUf(g&TUoo4]|R=E׹&jQ9_egv39Zb_Uv-S8zrkv{l5Q0 lfmq ҪfBYq_Ah5(>kT;uDu& :Fq^qv+ \\1R4 !d7 :#o%i%Ѳ#a9{H2$E˶U $vûr7Nƫi,<.  (čg3Tͯ,?vF1QUq00-zbhi{UUcu%ԜyïpbEYLoi>kvni͹jvbFQ1;ڦ֦f,F]A1$@Ά3Y )2DtYIŤqtܑ_dІs*,t3UwUcgQ10ʎī{99~QܦCc%xMqs\2LmAXͪ'7nN\nz|1«ӃW4X{ *b<:bXbs4Ms1KVC5ז^rk{)E;8QGbA1MN&LL &+݊;Vʸy1]zcR4PF $JNMc0ܻKL  xUhDZt纛tʨ:hb"Cq0Ţh"i-1/OqWLf"4&J-,b) 3բKTվcetgE,^K]iک]kZƍ-\8L"p,Le0ÊYQiLQ}1-\1+[L,JtgqbcQE;*#"-3W Xb׺)jŊffEQf-%3=]EbN6UUg\Ikb Z \\ :Hg#Uf#b:o.m5n]Tuυ6[kh&svZVjã p覈9io;fʛ jU);BʢAda11(I C*^iL8gqGr%W 7ƞF[FTOWQ4xL\:bfb"׋ÜHaz&&'ldʼntэʖ-3i)  +J6ₜ)/1zEQh=#if-F-L"KC;q&gFw$i2CԹV͔T- w4E1fh7LE=>W=%ۯuG=azwR4n}o)U3P&Ø{gE[َ^h{a *.Q/~`9xΕ1|D0|VuSL]sjh/33"7>&ƣ /^-{؉7Qoq"17]TuYӖTƻg)YNE!i9/NG$CkA&Z^OE 6@:Ԇ䰡&q+ɪmjbѷY;[paSŧ3}kNʦ3s VEb*{ru'64ZӋX:xtGe}b)wDMsM3h峐ctFk, m[ӥM7'6jfEP>ys}ywQ\UV>$v6tn.jbٵƘ{|pQ)1jfb4EvMAn8xQl :mmL۲ˉ <e P jV3iiʽ_RXDb& WsQWre1CLkļYUdq &(Z6#Pm .S0M?r=I^om58ʮCdSVĢ+cojc49L7T[xH䔐/HR l]eܤ %ak݋]:yʲ(nld,hZZ=ٸ&o>Dd Һ uG"1L߻3FS&3FS*sLN&&0 endstream endobj 1855 0 obj <>stream Adobed     '$''''$25552;;;;;;;;;;   ####''',,,   ####''',,,   ####''',,,""   g!1AQaq2"3BR #$%&'()*456789:CDEFGHIJSTUVWXYZbcdefghijrstuvwxyz 'e!Q1"ABSb #$%&'()*23456789:CDEFGHIJqRTUVWXYZacdefghijrstuvwxyz?ѢKq D uTQs K3pRe0  "_ bT1B U]֢f@ "-:ARP⤡TIRE1ԩv#: A*Z֪ZA7"ERъ.@j(M D)03^5̚"! %AMN(E@ ʓKnFu!Jj 3)0(@}^#'4"m:dxKAX@Q;$zQDJIB%nbEib JPTFFe(AI ")DB;Dlh !((]c/R×LiTiZf- 9MnԩMvEb<41|@|VU7S5d7Sh8ą, ur-ڔF|v'#6Ҿ>a'Қ:J|I78nSv:g4ldȾX/4cJz_/Ց<~:칹$›xtNjTuHmO2|Ŏ4ƞndjDz{M &gx]AdW^SL2`Ɇ5:IV,fiflpEfz,i_ 1Տe׎5X,[) [[1YyƬGizK*%W+4[-"NY;JbPw`me0|&T0tlSpsѬt=Qh"v)} ̦Tptlv}Jv+T[TFPʆΚ-4k(7'y*_q\\V6E,73Sr9G.ʵf"9.+wfV eFW&V/r%c6-S\rzzb `Z455S/NȍG 1gg6Q15b$ 0XŅ'('Zǟb 'j7PTBeI^f+:'(yVyO9 (=P +:'(b,U0[A缯,(ѷOdx8,ܩ*1]1zCtNWF"G*( 9DЬ*q]1=>$C$Cqj5h 2"&@u8˚aYV-: Z3Nt(y "\ˎ)6&eP20 1ذɘtYL9#"X.C0`MɌc#*J~e`5Bx9~vFH uS'=Me=(cMfV=csJv)йQN2DPēz“zMNǾt,xcJTaAۡ/FT%q,ބiq cYƃmiI*J;@A N' #8GiEp . cJ̤;2deAbxbx*ucJȖcƔezGE`M<[ȸ$,pǚSLKL"$M6e&>S6aiҾq9c7cJY)l, fi8I|QpSyګk<A{Ҽa[N-,y<#(S:}Mtw3ѧ;<TNB0hF1-9'H--&瑐)e|s `}Mtwy쓵QM*r):G-fk7?շVLX,,+Ҵ#LLgv 3`|-A:Gmfk78տf;Vtջ\10NS W< ;$^8&9t7Ye5,e1n+cao9c}3LR]E ^ˎ}z46)^ցldr}TgX`kceXUe+yYT^^0+4n-˷wĩ|,IQ<08fcAWK8ƉaّD6,m/)aH{ Q}\Wxy'L+^d+)Lenm>MRRn-Ŷ7K/h`x%t&W+&fi1oPQdX/4:,8 @|^ߤas!v҅sq:twc)M _ v7k^\Ԙ8^0,1RXk'y ̻//rx<-^'w֌F,p9<H* B)DQ'2kÙ@0<5UaY[MӢ=FE`q6vf;L\, qa\Ehu+H"c9 !bf&bx2.;DdW 22ni ǖ^,$'c7#crK,%7'Gc66V;&98Fsk a(_pHx5@Kf'Z?#z#(kFfGu.dܨȅxVXGec=>:𝅌YbkL>"gYV9K*>oFZV! a0- ES!m w˶DK , 38Þ18{% l'ڣ=N;vZ[RǕ;U#2)Fvʹ-U^=(Fj~]ADԪ%\[rSd&(J3`^67i.l"sd$lZUh[bYc#drgڔ,A1-#<тYm<ɻ9Цw-Bm5O*g, w< BEE Y.6$fʦ0 Sʼt΅6%6J(Ѵ]7[J'O*sTJ'l@p)ڐʥac>Ϛ畔d:Yrr7B1mUAc_lL.Q p@-Lf*`Yi+K =l.$vQKt!7B)(:ӰA6i@? beIX}EM1ge;DٲY]MYFrfczihL8&osSp'\:/A. qVYDDLJ#+ ;CXSMULFa]c{ܝr1Zlr<'i~&^ø&,l,)8ոɽhsL'97 &MYCp*J8w M1q=C`5A8j"x Y'Xcfo\c/4ۗ>$Eal-e,V.R|f%ym%m3XO'5֘,Eޭɛϔ¶8_ eK5nl&볕MTCV72'D*q;R$*\s0wU5RHL7o59Vce8"/>M8E\q4D׆|eXBhky.& ,ZZ0}<7 Xl1""9Y# ?,p<ҸV7 FHfa+vQeI\un󳩻Ω$S$MqUc!`q')69G,0<&0%s:U2DX|b2pS䶘m0%TQ$V7!1f"h|-0%ֵT5S$67'1&pN+\ "miUU*"LUa}E G<  .[iKJTy8㸒y'_"xDE~ItKTI-k mELd' M1l^p<<)cVsgm|̫`.phntP)4l6s@dtFj^m\xo `QkN1;<.`VVSڱWpM7Sa9n8$Dc>}i KaD໊,f=334ޥeJ=j8ec/JrzKnjϢ]c+aK.gXٶcj'ԋ| q.B<$~Y1.ɺ3wB"o&"-c0H̺\R0KOgF[1bm'si$b&I<5E H^3(d۔'kz~2L\Sn1^FJtH;3Rx$cĺu 5{(cc91a{ 5X=瓻Qއ+!WmtEY:DX(Ʊ4`ջc%m5 e̼nF۵F2uh}) +EܫeaJHw]94/W乘nޫ/rߝ{[oPi %W-Zb< c.o cEkym^xfi׷>L懲)NS-ˢN,Qhs^j3KQ|1,kcLiYLNPW.W:eE& GYbk |*tׂq*K99/W4-;T/BmfqBQ[;,#pXiXv+:j,My7j4@e28HWJ۠oXYV&x>ȈG (&.ytYcEyWV4ّh3!7Q\܁Ooa[4 )35 "mLF]0p tQkTf;@۴]v$046E^^0K(̭b1r^Օ*g(){ni[묥S6* T6k6IXM1VO*þ5L ,dC3![+3|﶐Shyv8%l1!c8KIƉx^1 Dܳ-0h1N P3j L 0RnR&`H&fKMYjf"@ }#i(9D 6Af0Hc 5BnB[54u3fBkPS@[!.k_tVȹעeNt` HJ TY 8:Ԅ@BM]Dm-#XbSZ}H[r|RƀEpBal9s"I(&6-J( -1X#:R7̝wZ$ ,_Y̥YZF4R`I@PV $$.:$ Ҫ:~D;Iw SYǤARɯHD0D曩E#(HJ\}5-oLx "^h*MlյW8fMF)&,mUj9lp ,$o]21lvD:]Y1JR=dIV@ U&@;4۲"ZA7T(4ɖTn+uEJܕ0 v1$%[BhU*$YЖ²5u&]~d%T 0B]vIpm%(LHZ c2D W9 $^ ɊԹJu*U &393|A2b P2jE*9d( Ikd`}%5W%ɶPn)Hvp kMQ6ڠJc1+'0VLR "A.AWQ@FH.̣"> wLȽJ+uPrh' dY)Qis2-&)QgD͸RH.5.UnrV+%S g0(H}A3y gT".UUJ"68@-6ƙ b 5Q)PtN*$!֋J`0Q Z& @m;UdݳxQqYdgH7fe*/mTD+JҡARj bH9 kdάa gJ M& VJ I 7Z㮤 vHEdL]xD2Eڤ 8LfQ+DIC* X&@oPRӵ8 IuH33 Rb_RX[ӂJ&,m蚠r "QHګM#r9Dc$B@=S4`n@eL\)bΓtBJ/,!,kRna5(Z34Di/X\ͲCd8$J,LE83( }3 k8&kA n)H8(LfZ J4R0P$ L[qBۢs4(.V6JY.4 Z j2$q  _e8ЂPd#N`@!llTbR2 M3%nP$.Gþ3f f/#06("nJcDm0D\͌IKdtz9#YP&*gjE*UIiBF8N|cQ*HIscNr:MP"ʉ(L̠{QA$E,$\LU6*$p2.N !5w蛐!% [;LoJזlLLA4@ TvKhlI1Ƒ If8MB- $kq 3Vv"ʸѩjJP`rh$($H&cBRE Npc:+@.$ٌ?@փb 0B5Q I.DV'2z I/ȨS"$EҋN0!}kTXˋX8A&@ȮȔ ;K`k^vJ][7]W6Imap\͍c3)*Qȼj-"UwCwEDRpJiP(_zA@WdlrATDfBʂ [j d`.JpD 6xiBM&M r32qjSRbs 0b5,COBEgdohЛ(HcD@X{ݾ&" קk9B ʅҀ!\'X!k(@V$WJPZMK.LhjK Cn2,UT(@\jjDC"@X&bɬPhqQ3D) /AeJY~t\Djŭrk]&J$٠+p3 kB͒nPcڲK^&=J/\"\1r#\{`(b"StUEEDKѴ&J 4.BY… \"ֻap* 1e(lV/ս9Y]!do V9tE&Bk)N "IUޣL_مD#xuP|BY$f&!4D%ԃ",AyEn@#Slip$푴[-?֣81IJ= 1KT]UZ&cX\$D(I0|J&̀+MxEP@U7'lvH^(p)pfjKE!"6h e|@,2zq-{7mQ![0f7 MUR\@pģl]Rbu[[(YTG2FB^(EB̘CڮrZ,qЅRKYĨ /%5NH܉DmS Ԙ˜j" s g!(5hc5D1"AP)pܸoy2ܗ_ P0Pw*\+Dee!"`58K&ԩqoXr˷s4YͳK#MV`Z[ralnDDT /9\(dBa3u*axp$ P ys(/QtZ4-"&aM\. nPyрR¢nRٳ5HH.&Y[KТE%MA (U ZgnMEELB&&J"Q֑H7FI%[HMhTi DdL0SEf@lPf-:ɁHת+mRqbǚ:)hjZLK h*Tw]rAI 7.5E*)7QD- uMIdԉ1ܮkNu ::`r|0[‚ȸkbgᓉ\ (EBQ M("bu"1kt@0DHTM /3NeTb';(2 d!(YNAf.o$@E u.کmqC_P` ZA@5J`tIƋ@ mPo)PEhI` cT$N8o #=E#BE0 /c[BNpUdy1PL]3`vJB6H7E%3Va0I ƹDҖ8\h+A5Z.mk7ËEJv@31*gY}ŠRzq0.LU-ꨴ"D % 288﫥0$VjjJLKb@ lљ1xB@*@P4_ uV-n.55+7A-aDSE)j-u .7*LFUlD4(H̢W4|2A06U]pQL)[UZZkUV2 &nNRcQzB:D㪖bYyWQVTU)m@ endstream endobj 1867 0 obj <>stream endstream endobj 1866 0 obj <>stream endstream endobj 1852 0 obj <>stream q /GS0 gs /Fm0 Do Q 0 0 0 1 K 1 j 1 J [0 2.997]0 d /GS1 gs q 1 0 0 1 74.3631 540.8533 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 71.3661 540.8533 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q [0 2.997]0 d q 1 0 0 1 74.3631 513.2455 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 71.3661 513.2455 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q 0 j 0 J q 1 0 0 1 70.8661 459.1763 cm 0 0 m 453.543 0 l S Q BT 0 0 0 1 k /T1_0 1 Tf 0.025 Tw 9 0 0 9 119.0551 730.4919 Tm [(P)45(A)45(TIENT)-9.9(S A)53(ND METHOD: it w)13(as a p)46(rospectiv)13.1(e tw)12(o-center study)32(. The study enrolled 35 w)12(omen with obstetr)-37(ic per)-37(ineal )]TJ -0.03 Tw 0 -1.111 TD [(trauma follow)12(ed by anal incontinence, who under)-31.9(w)12(ent delayed reconstruction of the sphincter)23(-lev)16(ator com)16(ple)-15(x in the )]TJ -0.014 Tw T* [(per)-37(iod 2019\2262022)]TJ /Span<>> BDC ( )Tj EMC [(at the Lomonosov Moscow S)28(tate U)22(niv)13(ersity R)21(esearch and Educational Center)51(. Preoperativ)13(ely ER)27(US )]TJ 0.024 Tw T* [(and TPUS w)13(as conducted. All patients under)-32(w)12(ent ov)13(erlap sphincteroplasty with subsecuent follow up. Af)-45.9(ter surg)12(er)-42.9(y )]TJ 0.009 Tw T* [(all patients w)12(ere ask)17(ed to f)-43(ill online-for)-14(ms with q)14(uestions from )0.5(W)30(e)-15(xner Incontinence Score, FIQL and PISQ-12 score. )]TJ 0.023 Tw 0 -1.111 TD [(Satistical ev)16(aluation with cor)-15.9(relation analysis w)13(as per)-33.9(for)-14(med.)]TJ 0.003 Tw 0 -1.111 TD [(RESUL)30(T)-10(S: the patients)33.1(\242 mean ag)12(e w)13(as 33 years \(SD)]TJ /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC [(5\), the number of bir)-40(ths v)16(ar)-37(ied from 1 to 3, and the mean time )]TJ -0.016 Tw T* [(from sym)16(p)13(tom onset to specialist visit w)13(as 39 months \(rang)12(e: 0\226240)]TJ /Span<>> BDC ( )Tj EMC [(months\). Defects in the e)-15(xter)-14(nal anal sphincter )]TJ 0.043 Tw T* [(\(EA)50(S\) )0.5(counted )0.5(47 )0.5(to )0.5(116 )0.5(deg)14(rees. )0.6(The )0.5(rang)12(e )0.5(of )0.5(defect )0.6(sizes )0.5(in )0.5(the )0.5(inter)-13.9(nal )0.5(anal )0.5(sphincter )0.5(\(IA)50(S\) )0.5(rang)12(ed )0.5(from )0.5(76 )0.5(to )]TJ 0.029 Tw T* [(177 deg)14(rees. The av)13(erag)12(e follow-up per)-36.9(iod for patients w)13(as 7 months, with a maximum per)-36.9(iod of 4 years. The av)12.9(er)]TJ 0 Tw 44.743 0 Td (-)Tj -0.006 Tw -44.743 -1.111 Td [(ag)12(e deg)14(ree of incontinence according to the W)30(e)-15(xner Incontinence Score and q)14(uality of life according to the FIQL and )]TJ 0.023 Tw T* [(PISQ-12 scale before the inter)-42(v)13(ention w)12(ere 13 \(SD)]TJ /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (3.5\), 1.9 \(SD)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0.5\) and 17 \(SD)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC [(6.8\), respectiv)13(ely)32(. Af)-45.9(ter the )]TJ -0.011 Tw T* [(treatment, the scores w)12(ere 2,8\(SD)]TJ /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (2,9\), 3,6\(SD)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,6\), 8,2\(SD)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC [(3,5\). N)17(o cor)-16(relation w)13(as found betw)12(een ultrasound )]TJ 0.023 Tw T* [(parameters and the results of the incontinence g)14(rade and q)14.1(uality of life scores.)]TJ 0.007 Tw 0 -1.111 TD [(C)21(ON)22(CLUSION: the ef)-40(fectiv)13(eness of surgical treatment of postpar)-39.9(tum anal incontinence did no)13(t depend on the size of )]TJ 0.023 Tw 0 -1.111 TD [(the inter)-13.9(nal or e)-15(xter)-13.9(nal sphincter defect, as w)12(ell as on o)13(ther factors obtained by ultrasound diagnostics.)]TJ /T1_1 1 Tf 0.01 Tc -0.01 Tw 8 0 0 8 70.9061 565.2226 Tm [(KEYW)22(ORDS:)]TJ /T1_0 1 Tf 0 Tc 0.023 Tw 4.948 0 Td [( anal incontinence, O)25.1(A)49.9(SIS, sphincteroplasty)42.1(, obstetr)-36.9(ic injur)-43(y of the per)-37(ineum, anal incontinence, 3D ultrasound e)-14.9(x)10(amination)]TJ /T1_1 1 Tf 0.01 Tc 0.018 Tw -4.948 -1.909 Td [(C)19(ONFL)-33(ICT)5( OF)5( INTE)25(REST)62(:)]TJ /T1_0 1 Tf 0 Tc 0.023 Tw 9.871 0 Td [( The authors declare no conf)-22(lict of interest)]TJ /T1_1 1 Tf 0.037 Tc 0.062 Tw -9.871 -2.617 Td [(F)3.2(O)-4.6(R)8.7( C)-17.5(I)-15.6(T)45.4(A)37.6(T)-24.5(I)-1.3(ON:)]TJ /T1_2 1 Tf 0.023 Tc 0.071 Tw 6.507 0 Td [( M)-8.7(a)-10.2(r)-30.8(k)-24.2(a)-10.2(r)-60.6(y)-24.1(a)-7.6(n)]TJ /Span<>> BDC ( )Tj EMC [(D)16.4(.R)-21.4(.)-23.5(, L)-25.6(u)-9.6(k)-41.1(i)-5.1(a)-7.6(n)-11.9(o)-10.2(v)]TJ /Span<>> BDC ( )Tj EMC [(A)-23(.)-7.3(M)-7.1(.)-23.5(, K)-18.2(i)-7.4(s)-22.9(e)-17.9(l)-23.7(e)-15.8(v)]TJ /Span<>> BDC ( )Tj EMC [(D)16.4(.)12.4(O)11.4(.)-23.5(, A)-8.4(g)-8.1(a)-8.8(p)-22.3(o)-10.3(v)]TJ /Span<>> BDC ( )Tj EMC [(M)-7.1(.)-23.9(A)-23(. P)-18.6(r)-15.8(o)-18.6(g)-8.8(n)-11.9(o)-15.8(s)-22.9(e)-22.8(s o)-12.1(f i)-3.2(n)-14.4(j)-3.5(u)-7.6(r)-60.6(y s)-17.7(c)-21.5(a)-11.4(l)-23.7(e i)-3.2(n s)-8.7(u)-7.6(r)-16.7(g)-29(i)-4.9(c)-21.5(a)-11.4(l t)-30.8(r)-19.1(e)-13(a)-18.2(t)-26.1(m)-16.6(e)-11.5(n)-17.3(t o)-12.1(f p)-22.3(o)-15.8(s)-29.3(t)23.8(-)]TJ 0.011 Tw -6.512 -1.2 Td [(t)-30.8(r)-30.8(a)-9.1(u)-7(m)-8.3(a)-18.2(t)-46.2(i)-5(c a)-7.6(n)-7.8(a)-11.4(l i)-3.2(n)-10(c)-6.5(o)-9.2(n)-17.3(t)-46.1(i)-3.2(n)-16.2(e)-11.4(n)-10(c)-9.8(e)-6.8(. )]TJ /T1_0 1 Tf 0.033 Tc -0.033 Tw [(K)13.9(ol)3.6(op)2.4(r)3.2(o)3.4(k)-19.2(t)2.2(ol)3.6(o)-3.2(g)-13.2(i)6.7(a)5.8(.)]TJ /T1_2 1 Tf 0.023 Tc 0.011 Tw 19.945 0 Td [( 2)-8.9(0)-3.8(2)8.8(4)10.2(;)9.8(2)-10.3(3)6(\()37.7(1)44.3(\))14.5(:)29.3(7)12.6(1)26.4(\226)-23.7(8)-1.5(1)4.2(. \()-0.9(i)-3.2(n R)-6.5(u)-21.9(s)-22.3(s)-15.5(.)43.2(\))10.4(. h)-17.2(t)-49.4(t)-29.4(p)-18.7(s)-8(:)1.9(/)84.7(/)36.4(d)-11(o)-12.6(i.)2.8(o)-11.8(r)-16.8(g)-22.8(/)11.3(1)13.9(0)6.5(.)-5.5(3)7.9(3)-16(8)1.3(7)4.6(8/)8(2)-9(0)9.3(7)-1.9(3)-13.3(-)41.2(7)10.7(55)-8.9(6)-26.7(-)9.7(2)-8.9(0)-3.8(2)8.8(4)-28.5(-)9.7(2)-10.3(3)-13.3(-)55.1(1)26.9(-)41.2(7)12.6(1)26.9(-)-25.2(8)-1.5(1)]TJ /T1_1 1 Tf 0.01 Tc 0.035 Tw -19.94 -2.617 Td [(\026\020\021\033\030)5( \020\036\017)5( \013\033\021\033\013\023\030\037\023:)]TJ /T1_0 1 Tf 0 Tc 0.04 Tw 10.611 0 Td ( \035\205\013\022\002\021\n\027 \201\023\031\013\t\026\021\030\032 \240\026\ \013\t\025\003\n\027\025\006, \240\210\214 \025\003. \240.\216.)Tj /Span<>> BDC ( )Tj EMC (\035\n\003\n\021\n\t\n\027\026, \013\026\f\031\030\032\026 \004\025\032\205\ \032\202\025\025 \225\225\240, \035\n\003\n\021\n\t\n\027\t\013\025\017 \ \033\032\n\t\033\031\013\024, )Tj 0.023 Tw -10.616 -1.2 Td (\030.)Tj /Span<>> BDC ( )Tj EMC (27, \013\n\032\033.)Tj /Span<>> BDC ( )Tj EMC (10, \240\n\t\013\027\026, 119192, \212\n\t\t\025\002; e-mail: alexmaxl@m\ ail.ru)Tj /T1_1 1 Tf 0.01 Tc -0.036 Tw 0.005 -1.2 Td [(ADDRESS)4.9( F)13(OR)5( C)19(ORRESPONDEN)23(CE:)]TJ /T1_0 1 Tf 0 Tc -0.031 Tw 13.942 0 Td [( Ale\004ander M. Lukyanov)63.1(, R)21(esident of the Depar)-40(tment of Surg)12(er)-43(y \2461 of the Medical R)21(esearch Educational Center)61.1(, )]TJ 0.023 Tw -13.947 -1.2 Td [(Lomonosov Moscow S)28.1(tate U)22(niv)13(ersity)42(, Lomonosovsky p)46(r)23(-t, 27, bld.)]TJ /Span<>> BDC ( )Tj EMC [(10, Moscow)52(, 199192, R)22(ussia; e-mail: ale)-15(xmaxl@mail.ru)]TJ 0 Tw 0 -2.792 TD (\200\026\024\026 \033\n\t\024\205\033\023\031\021\025\002)Tj /Span<>> BDC ( )Tj EMC (\227 21.08.2023)Tj /Span<>> BDC ( )Tj EMC 19.488 0 Td (\n\t\023\031 \030\n\032\026\005\n\024\013\025)Tj /Span<>> BDC ( )Tj EMC (\227 05.10.2023)Tj /Span<>> BDC ( )Tj EMC 18.78 0 Td (\032\025\021\002\024\n \013)Tj /Span<>> BDC ( )Tj EMC (\033\205\005\023\025\013\026\203\025\025)Tj /Span<>> BDC ( )Tj EMC (\227 12.02.2024)Tj ( )Tj -38.268 -1.375 Td (Received)Tj /Span<>> BDC ( )Tj EMC (\227 21.08.2023)Tj /Span<>> BDC ( )Tj EMC 19.488 0 Td (Revised)Tj /Span<>> BDC ( )Tj EMC (\227 05.10.2023)Tj /Span<>> BDC ( )Tj EMC 18.78 0 Td (Accepted for publication)Tj /Span<>> BDC ( )Tj EMC (\227 12.02.2024)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 70.936 396.0239 Tm (\023\023\034\226\034\022\031\034)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf 0 Tc 0.021 Tw 10 0 0 10 70.8661 371.6679 Tm (\202\022\031\001\036\030\f\022\026\016 \021\030\026\r\n\026 \023\030\024\ \n\036\032\027\024\f\021\017 \(\202\230\215\) III\226IV \f\021\036\023\036\ )Tj 0 Tw (-)Tj 0.092 Tw 0 -1.218 TD (\027\017, \016\r\035\016\016\f\034 \r\036\007\031\013\036\005 \023\030\017\ \004\017\027\024\005 \023\024\f\021\021\030\026\r\n\026\021\017\004\036\f\ \022\024\020\024 )Tj 0.299 Tw T* (\026\027\026\035\034\027\024\020\024 \027\036\007\036\030\032\026\027\017\ \016 \(\202\203\), \027\026\004\017\021\036\035\034\027\024 \f\027\017\032\ \026\036\021 )Tj 0.072 Tw T* (\022\026\004\036\f\021\r\024 \032\017\027\017 [1]. \217\026\f\023\030\024\ \f\021\030\026\027\036\027\027\024\f\021\034 \202\230\215 \f\024\b\030\026\ )Tj 0 Tw (-)Tj 0.203 Tw T* (\027\016\036\021\f\016 \027\026)Tj /Span<>> BDC ( )Tj EMC (\031\030\024\r\027\036 8\22610% \r\f\036\b \036\f\021\036\f\021\r\036\027\ \027\t\b \030\024\007\024\r, )Tj 0 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\021\036\027\007\036\027\006\017\017 \022)Tj /Span<>> BDC ( )Tj EMC (\f\027\017\032\036\027\017\033 \027\036 \027\026\002\035\033\007\026\036\ \021\f\016 [2].)Tj 0.662 Tw T* (\210\f\024\002\036\027\027\024\f\021\034\033 \035\036\004\036\027\017\016\ \023\024\f\035\036\007\f\021\r\017\005 \026\022\031\001\036\030\f\022\024\ \005 )Tj 0.208 Tw T* (\021\030\026\r\n\t \016\r\035\016\036\021\f\016 \027\036\024\002\b\024\007\ \017\n\024\f\021\034 \023\030\017\r\035\036\004\036\027\017\016 \n\036\032\ )Tj 0 Tw (-)Tj 0.085 Tw T* (\007\017\f\006\017\023\035\017\027\026\030\027\024\005 \022\024\n\026\027\ \007\t \f\023\036\006\017\026\035\017\f\021\024\r \027\036\026\r\017\f\017\ \n\024 )Tj 0.118 Tw T* (\024\021 \f\030\024\022\026 \021\030\026\r\n\t [3,4]. \230\026\022, \023\ \030\017)Tj /Span<>> BDC ( )Tj EMC (\030\026\027\027\036\005 \007\017\026\020\027\024\f\021\017\022\036 )Tj 0.054 Tw T* (\026\022\031\001\036\030\f\022\024\005 \021\030\026\r\n\t \r)Tj /Span<>> BDC ( )Tj EMC (\030\024\007\024\r\024\n \026\035\036, \f\024\020\035\026\f\027\024 \f\024\ \r\030\036)Tj 0 Tw (-)Tj 0.113 Tw T* (\n\036\027\027\t\n \f\021\026\027\007\026\030\021\026\n [5], \023\024\022\ \026\026\027\026 \027\036\026\n\036\007\035\017\021\036\035\034\027\026\ \016 )Tj -0.055 Tw T* (\030\036\022\024\027\f\021\030\031\022\006\017\016 \021\026\024\r\024\020\ \024 \007\027\026 \f)Tj /Span<>> BDC ( )Tj EMC (\023\030\017\r\035\036\004\036\027\017\036\n \b\017\030\031\030\020\026-\ )Tj 0.2 Tw T* (\023\030\024\022\021\024\035\024\020\026, \026)Tj /Span<>> BDC ( )Tj EMC (\023\030\017 \024\021\f\030\024\004\036\027\027\024\005 \f\235\017\027\022\ \021\036\030\024\023\036\030\017\027\036\024)Tj /Span<>> BDC (-)Tj EMC 0.222 Tw T* [(\023\035\026\f\021\017\022\036 \f\024\f\021\026\r \n\036\032\007\017\f\006\ \017\023\035\017\027\026\030\027\024\005 )0.5(\022\024\n\026\027\007\t \036\013\036 )]TJ 0.291 Tw T* (\001\017\030\036)Tj /Span<>> BDC ( )Tj EMC [(\227 \023\030\024\022\021\024\035\024\020\017, \020\017\027\036\022\024\035\ \024\020\017, )0.5(\235\031\027\022\006\017\024\027\026\035\034\027\t\036 )]TJ 0 Tw T* (\007\017\026\020\027\024\f\021\t \017)Tj /Span<>> BDC ( )Tj EMC (\027\036\005\030\024\b\017\030\031\030\020\017.)Tj 1.027 Tw T* (\025\030\026\036\031\020\024\035\034\027\t\n \022\026\n\027\036\n \035\036\ \004\036\002\027\024-\007\017\026\020\027\024\f\021\017\004\036\f\022\024\ )Tj 0 Tw (-)Tj 0.361 Tw T* [(\020\024 )0.5(\023\030\024\021\024\022\024\035\026 )0.5(\016\r\035\016\036\021\f\016 )0.6(\r\017\031\026\035\017\026\006\017\016 )0.6(\f\021\036\023\036\027\017 )0.5(\023\024)]TJ 0 Tw (-)Tj 0.634 Tw T* [(\r\030\036\032\007\036\027\017\016 )0.5(\n\t\001\036\004\027\024\020\024 \022\026\030\022\026\f\026, \024\f\027\024\ \r\027\031\033 )0.5(\030\024\035\034 )]TJ 0.131 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC 0.837 0 Td [(\022\024\021\024\030\024\005 )0.5(\017\020\030\026\036\021 )0.6(\031\035\034\021\030\026\r\031\022\024\r\026\016 )0.5(\007\017\026\020\027\024\f\021\017\022\026 )0.6([6,7]. )]TJ 0.063 Tw -0.837 -1.218 Td (\223\031\r\f\021\r\017\021\036\035\034\027\024\f\021\034 \017)Tj /Span<>> BDC ( )Tj EMC (\f\023\036\006\017\235\017\004\027\024\f\021\034 \220\027\007\024\030\036\ \022\021\026\035\034\027\024\020\024 )Tj -0.086 Tw T* (\211\003\222 \f)Tj /Span<>> BDC ( )Tj EMC (3D-\n\024\007\036\035\017\030\024\r\026\027\017\036\n \027\036 \031\f\021\ \031\023\026\036\021 \n\026\020\027\017\021\027\024-\030\036\024)Tj 0 Tw (-)Tj 0.087 Tw T* (\027\026\027\f\027\024\005 \021\024\n\024\020\030\026\235\017\017, \026)Tj /Span<>> BDC ( )Tj EMC (\023\024\021\024\n\031, \031\004\017\021\t\r\026\016 \027\026\004\017\021\ \036\035\034)Tj 0 Tw (-)Tj 0.062 Tw T* (\027\024 \n\036\027\034\001\031\033 \f\021\024\017\n\024\f\021\034 \017\f\ \f\035\036\007\024\r\026\027\017\016 \017)Tj /Span<>> BDC ( )Tj EMC (\r\024\n\024\032\027\024\f\021\034 )Tj 0.078 Tw 23.244 32.881 Td [(\024\002\255\036\n\027\024\005 )0.6(\030\036\022\024\027\f\021\030\031\022\006\017\017 )0.6(\023\026\021\024\035\024\020\017\004\036\f\022\024\020\024 )0.5(\023\030\024\006\036\f\f\026, )]TJ 0.25 Tw T* [(\031\022\026\026\027\027\t\005 \n\036\021\024\007 \r\017\031\026\035\017\ \026\006\017\017 )0.5(\016\r\035\016\036\021\f\016 \253\024\035\024\021\t\n )]TJ 0 Tw T* (\f\021\026\027\007\026\030\021\024\n\273 \007\017\026\020\027\024\f\021\017\ \022\017 \026\022\031\001\036\030\f\022\024\005 \021\030\026\r\n\t [8].)Tj 0.332 Tw T* (\215\024\f\035\036 \031\f\021\026\027\024\r\035\036\027\017\016 \007\017\ \026\020\027\024\026 \202\203 \f)Tj /Span<>> BDC ( )Tj EMC (\023\024\007\021\r\036\030\032\007\036\027)Tj 0 Tw (-)Tj 0.231 Tw T* (\027\t\n \007\036\235\036\022\021\024\n \f\235\017\027\022\021\036\030\027\ \024\020\024 \022\024\n\023\035\036\022\f\026 \r\f\021\026\036\021 \r\024\ )Tj 0 Tw (-)Tj 0.524 Tw T* (\023\030\024\f \024)Tj /Span<>> BDC ( )Tj EMC (\r\t\002\024\030\036 \023\036\030\r\017\004\027\024\005 \021\036\b\027\024\ \035\024\020\017\017 \035\036\004\036\027\017\016. )Tj 0.075 Tw T* (\230\030\026\007\017\006\017\024\027\027\024 \f\004\017\021\026\036\021\f\ \016, \004\021\024 \027\026\035\017\004\017\036 \007\036\235\036\022\021\ \026 \026\027\026\035\034)Tj 0 Tw (-)Tj 0.025 Tw T* (\027\t\b \f\235\017\027\022\021\036\030\024\r \023\030\024\021\016\032\036\ \027\027\024\f\021\034\033 \002\024\035\036\036 100\260)Tj 0 Tw 5.83 0 0 5.83 491.9858 326.2859 Tm ( )Tj 10 0 0 10 493.4901 322.9559 Tm (\016\r\035\016\036\021)Tj (-)Tj -0.019 Tw -19.018 -1.218 Td (\f\016 \023\024\022\026\026\027\017\036\n \022)Tj /Span<>> BDC ( )Tj EMC (\b\017\030\031\030\020\017\004\036\f\022\024\n\031 \035\036\004\036\027\017\ \033, \026)Tj /Span<>> BDC ( )Tj EMC (\n\036\027\034\001\017\005 )Tj 0.134 Tw T* (\030\026\n\036\030 \023\024\r\024\035\016\036\021 \027\026\004\017\027\ \026\021\034 \035\036\004\036\027\017\036 \f)Tj /Span<>> BDC ( )Tj EMC (\002\026\024\r\024\005 \022\024\027)Tj 0 Tw (-)Tj -0.039 Tw T* (\f\036\030\r\026\021\017\r\027\024\005 \021\036\030\026\023\017\017 \017\ )Tj /Span<>> BDC ( )Tj EMC (\027\036\005\030\024\n\024\007\031\035\016\006\017\017 [9]. \221)Tj /Span<>> BDC ( )Tj EMC (\007\030\031\020\024\005 )Tj 0.034 Tw T* (\f\021\024\030\024\027\t, \r)Tj /Span<>> BDC ( )Tj EMC (\n\036\032\007\031\027\026\030\024\007\027\t\b \023\031\002\035\017\022\026\ \006\017\016\b \r\f\021\030\036\004\026\036\021\f\016 )Tj 0.058 Tw T* (\n\027\036\027\017\036 \024)Tj /Span<>> BDC ( )Tj EMC [(\027\036\024\002\b\024\007\017\n\024\f\021\017 \024\002\016\026\021\036\ \035\034\027\024\020\024 )0.5(\r\t\023\024\035\027\036\027\017\016 )]TJ 0.184 Tw T* (\b\017\030\031\030\020\017\004\036\f\022\024\005 \022\024\030\030\036\022\ \006\017\017 \007\036\235\036\022\021\026 \n\t\001\036\004\027\024\020\024\ \022\026\030)Tj 0 Tw (-)Tj T* (\022\026\f\026 \035\033\002\024\020\024 \030\026\n\036\030\026 \023\030\ \017)Tj /Span<>> BDC ( )Tj EMC (\036\020\024 \r\t\016\r\035\036\027\017\017 [10].)Tj -0.005 Tw T* [(\037\036\035\034\033 )0.5(\027\026\001\036\020\024 )0.5(\017\f\f\035\036\007\024\r\026\027\017\016 )0.5(\f\021\026\035\024 )0.5(\017\031\004\036\027\017\036 )0.6(\r\024\n\024\032)]TJ 0 Tw (-)Tj 0.23 Tw T* [(\027\024\f\021\017 )0.5(\017\f\023\024\035\034\024\r\026\027\017\016 )0.6(\023\024\022\026\026\021\036\035\036\005 )0.6(\220\027\007\024\030\036\022\021\026\035\034\027\024\020\024 )]TJ 0.17 Tw T* (\(\224\217\211\003\222\) \017)Tj /Span<>> BDC ( )Tj EMC [(\021\030\026\027\f\023\036\030\017\027\036\026\035\034\027\024\020\024 )0.5(\031\035\034\021\030\026\r\031\022\024\r\024\020\024 \017\f)]TJ 0 Tw (-)Tj -0.037 Tw T* (\f\035\036\007\024\r\026\027\017\016 \(\230\215\211\003\222\) \007\035\016\ \024\023\030\036\007\036\035\036\027\017\016 \021\026\022\021\017\022\017\ \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\020)Tj 0 Tw (-)Tj 0.393 Tw T* (\027\024\017\030\024\r\026\027\017\016 \030\036\031\035\034\021\026\021\ \024\r \b\017\030\031\030\020\017\004\036\f\022\024\020\024 \035\036\004\ \036\027\017\016 )Tj 0 Tw T* (\023\024\f\021\021\030\026\r\n\026\021\017\004\036\f\022\024\005 \026\027\ \026\035\034\027\024\005 \017\027\022\024\027\021\017\027\036\027\006\017\ \017.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0.01 Tc 0.018 Tw 14 0 0 14 303.3769 128.1078 Tm [(\f\026\017\031\034\022\024\232)5( \031)5(\016)-18.3(\240\034)-31(\024)35(\037\226\232)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf 0 Tc 0.112 Tw 10 0 0 10 303.3071 103.7519 Tm [(\215\030\024\r\036\007\036\027\024 )0.6(\023\030\024\f\023\036\022\021\017\r\027\024\036 )0.5(\007\r\031\006\036\027\021\030\024\r\024\036 )0.6(\017\f\f\035\036\007\024\r\026)]TJ 0 Tw (-)Tj -0.046 Tw T* [(\027\017\036 \220\235\235\036\022\021\017\r\027\024\f\021\017 )0.5(\024\021\f\030\024\004\036\027\027\024\020\024 \b\017\030\031\030\020\017\ \004\036\f\022\024\020\024 \035\036)]TJ 0 Tw (-)Tj -0.018 Tw T* [(\004\036\027\017\016 )0.6(\023\024\f\035\036\030\024\007\024\r\t\b )0.5(\021\030\026\r\n )0.5(\023\030\024\n\036\032\027\024\f\021\017 )0.6(\031)]TJ /Span<>> BDC ( )Tj EMC 17.801 0 Td (\023\026\006\017\036\027\021\024\022 )Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 0 Tw 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\033\030\031\030\213\b)-20.9(\035\231\213\233\t \021\032)50(\b)42(\032\231\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj -51.938 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 23, \023\0221)69(, 202)69(4)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 23, \023\0221)69(, 202)69(4)]TJ /T1_5 1 Tf 25 0 0 25 28.165 56.0378 Tm (72)Tj ET endstream endobj 1849 0 obj [1868 0 R] endobj 1850 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\034\002\025\202\001\025)21(\222 \006)-10(\026)11(\016\221\016\001\220 \221\025\r\002\016\217)-20.9(\201\016\001\220\203 \026)11(\013\222\025\r\025\202)10.1(\025 \201\001\013 \r\022\007\016\017\016\001\220\220 )]TJ 0 -1 TD [(\221\025\006)-10(\026)-31(\026\002\013\r\024\013\026\220\017\016\006\n)10(\025\202)10(\025 \013\001\013\007\216\001\025\202)10(\025 \001\016\201\016\002\217\013\001\220\205)]TJ 42.45 1 Td [(Pr)20(ognoses of injur)-30.9(y scale in sur)31(gical tr)31(eatment )]TJ 4.112 -1 Td [(of post-tr)21(aumatic anal incontinence)]TJ ET 0 0 0 1 K 1 j 1 J [0 2.997]0 d /GS1 gs q 1 0 0 1 46.0167 284.4104 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 43.0197 284.4104 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q [0 2.997]0 d q 1 0 0 1 46.0167 247.2026 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 43.0197 247.2026 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q BT 0 0 0 1 k /T1_1 1 Tf 10 0 0 10 42.5197 724.8299 Tm (https://doi.org/10.33878/2073-7556-2024-23-1-71-81)Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 0.023 Tw 19 0 0 19 51.9748 695.3259 Tm [(\034\002\025\202\001\025)21(\222 \006)-10(\026)11(\016\221\016\001\220 \221\025\r\002\016\217)-20.9(\201\016\001\220\203 \026)11(\013\222\025\r\025\202)10(\025 \201\001\013 \r\022)-23.3(\007\016\017\016\001\220\220 )]TJ 2.086 -1.105 Td [(\221\025\006)-10(\026)-31(\026\002\013\r\024\013\026\220\017\016\006\n)10.1(\025\202)10(\025 \013\001\013\007\216\001\025\202)10.1(\025 \001\016\201\016\002\217\013\001\220\205)]TJ 0 0 0 1 k /GS1 gs 0 Tw 14 0 0 14 42.5197 649.822 Tm [(\005\013\002\n\013\002\216\205\001\022)-23.2(\255.\033)124(.)]TJ 8.162 0 0 8.162 133.411 654.484 Tm (1)Tj 0.023 Tw 14 0 0 14 138.0469 649.822 Tm [(, \035\215\n\216\205\001\025\r\022)-23.2(\b)-31(.\005.)]TJ 0 Tw 8.162 0 0 8.162 232.3156 654.484 Tm (1)Tj 0.023 Tw 14 0 0 14 236.9515 649.822 Tm [(, \037)20(\220\006\016\007\016\r\022)-23.2(\255.\036.)]TJ 0 Tw 8.162 0 0 8.162 323.0307 654.484 Tm (2)Tj 0.023 Tw 14 0 0 14 327.6667 649.822 Tm [(, \b\202)10(\013\221\025\r\022)-23.2(\005.\b)-31(.)]TJ 0 Tw 8.162 0 0 8.162 409.4475 654.484 Tm (3)Tj 5.83 0 0 5.83 42.5197 635.4827 Tm (1)Tj 0.023 Tw 10 0 0 10 45.8311 632.1527 Tm [(\005\031)-11(\240 \220\024\016\001\220 \005.\004.\022)-23.3(\035\025\024\025\001\025\006\025\r\013, \225\013\n\215\007\216)21(\026)11(\016\026 \225\215\001\201\013\024\016\001\026)11(\013\007\216\001\025\203 \024\016\201\220\227\220\001\020 \(\215\007.\022\ )-23.3(\035\016\001\220\001\006\n\220\016 \031)80(\025\002\020, \201.\022)-23.3(1)69(, \202)62(.\022)-23.3(\005\025\006\n\r\013, )]TJ -0.331 -1.2 Td [(1)212(1)138(999)125(1)69(, \033\025\006\006\220\205\))]TJ 0 Tw ( )Tj 5.83 0 0 5.83 42.5197 611.4827 Tm (2)Tj 0.023 Tw 10 0 0 10 45.8311 608.1527 Tm [(\210\031\214)42(\240 \253\213\005\030\226 \n)10(\025\007\025\221\002\025\n)-9.9(\026)11(\025\007\025\202\220\220 \220\024\016\001\220 \b)-30.9(.\213.\022)-23.3(\033\020\217\220\207\273 \005\220\001\222\201\002\013\r\013 \033\025\006\ \006\220\220 \(\215\007.\022)-23.3(\021\013\007\205\024\013 \b)-20.9(\201\220\007\205, \201.\022)-23.3(2, \202)62.1(.\022)-23.3(\005\025\006\n\r\013, )]TJ -0.331 -1.2 Td [(1)125(23)58(423, \033\025\006\006\220\205\))]TJ 0 Tw ( )Tj 5.83 0 0 5.83 42.5197 587.4828 Tm (3)Tj 0.023 Tw 10 0 0 10 45.8311 584.1528 Tm [(\210\031)83(\b\036)20(\240 \004\036 \253\214\013\007\026\220\203\006\n\220\203 \225\016\201\016\ \002\013\007\216\001\020\203 \215\001\220\r\016\002\006\220\026)11.1(\016\026 \220\024\016\001\220 \030\024\024\013\001\215\220\007\013 \037)40.9(\013\001\026)11(\013\273 \(\215\007.\022)-23.3(\b)-31(.\213\016\r\006\n)10(\025\202)10(\025, \201.\022)-23.3(1)150(4, )]TJ -0.331 -1.2 Td [(\202)62(.\022)-23.3(\037)41(\013\007\220\001\220\001\202\002\013\201, 2360)25(4)103(1)69(, \033\025\006\006\220\205\))]TJ /T1_1 1 Tf 0.013 Tw 9 0 0 9 90.7087 553.6489 Tm (\037\036\035\034: \n\203\031\021\013\026 \033\032\n\202\021\n\t\024\025\006\ \031\t\013\n\202\n \033\n\024\031\021\203\025\026\023\026 \033\n\013\026\ \016\026\024\031\023\031\017 \r\021\030\n\032\031\013\024\026\023\022\021\ \n\202\n \205\023\022\024\032\026\016\027\205\013\n\027\n\202\n \025\t\t\ \023\031\030\n\027\026\021\025\002 )Tj -0.002 Tw 0 -1.111 TD (\(\230\212\214\221\215\) \025)Tj /Span<>> BDC ( )Tj EMC (\024\032\026\021\t\033\031\032\025\021\031\026\023\022\021\n\202\n \205\023\ \022\024\032\026\016\027\205\013\n\027\n\202\n \025\t\t\023\031\030\n\027\ \026\021\025\002 \(\220\214\221\215\) \027)Tj /Span<>> BDC ( )Tj EMC (\004\025\032\205\032\202\025\006\031\t\013\n\003 \023\031\006\031\021\025\ \025 \033\n\t\024\024\032\026\027)Tj 0 Tw (-)Tj 0.023 Tw T* (\003\026\024\025\006\031\t\013\n\202\n \026\021\026\023\022\021\n\202\n \ \021\031\030\031\032\204\026\021\025\002 \(\201\217\).)Tj 0.302 Tw T* (\201\037\215\036\217\220\235 \215)Tj /Span<>> BDC ( )Tj EMC (\240\036\220\255\200\235: \033\032\n\027\031\030\031\021\n \033\032\n\t\033\ \031\013\024\025\027\021\n\031 \030\027\205\203\031\021\024\032\n\027\n\031\ \025\t\t\023\031\030\n\027\026\021\025\031 \r\f\f\031\013\024\025\027\021\ \n\t\024\025 \n\024\t\032\n)Tj 0 Tw (-)Tj 0.188 Tw T* (\006\031\021\021\n\202\n \004\025\032\205\032\202\025\006\031\t\013\n\202\ \n \023\031\006\031\021\025\002 \033\n\t\023\031\032\n\030\n\027\020\004\ \024\032\026\027\003 \033\032\n\003\031\204\021\n\t\024\025 \205)Tj /Span<>> BDC ( )Tj EMC (\033\026\203\025\031\021\024\n\013 \t)Tj /Span<>> BDC ( )Tj EMC (\032\026\016\023\025\006\021\n\017 \t\024\031\033\031\021\022\007 )Tj 0.028 Tw 0 -1.111 TD (\033\n\027\032\031\204\030\031\021\025\002 \t\f\025\021\013\024\031\032\021\ \n\202\n \013\n\003\033\023\031\013\t\026 \033\n)Tj /Span<>> BDC ( )Tj EMC (\030\026\021\021\020\003 \230\212\214\221\215 \025)Tj /Span<>> BDC ( )Tj EMC (\220\214\221\215. \216)Tj /Span<>> BDC ( )Tj EMC (\025\t\t\023\031\030\n\027\026\021\025\025 \033\032\025\021\002\023\025 \ \205\006\026\t\024\025\031 35 \204\031\021)Tj 0 Tw (-)Tj 0.048 Tw 0 -1.111 TD [(\211\025\021 )0.5(\t)]TJ /Span<>> BDC ( )Tj EMC [(\026\021\026\023\022\021\020\003 )0.5(\021\031\030\031\032\204\026\021\025\031\003, )0.6(\027\n\016\021\025\013\001\025\003 )0.5(\027\t\023\031\030\t\024\027\025\031 )0.5(\026\013\205\001\031\032\t\013\n\017 )0.6(\024\032\026\027\003\020 )0.5(\(\201\220\), )0.5(\013\n\024\n\032\020\003 )0.5(\005\020\023\026 )0.5(\027\020\033\n\023\021\031\021\026 )]TJ 0.023 Tw T* (\n\024\t\032\n\006\031\021\021\026\002 \032\031\013\n\021\t\024\032\205\013\ \203\025\002 \t\f\025\021\013\024\031\032\021\n-\023\031\027\026\024\n\032\ \021\n\202\n \013\n\003\033\023\031\013\t\026 \027)Tj /Span<>> BDC ( )Tj EMC (\033\031\032\025\n\030 2019\2262022)Tj /Span<>> BDC ( )Tj EMC (\202\202.)Tj 0.068 Tw T* (\212\036\221\214\035\034\220\201\220\235: \t\032\031\030\021\025\017 \027\ \n\016\032\026\t\024 \033\026\203\025\031\021\024\n\013 \t\n\t\024\026\027\ \025\023 33 \202\n\030\026 \(SD)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (5\), \013\n\023\025\006\031\t\024\027\n \032\n\030\n\027 \027\026\032\022\ \025\032\n\027\026\023\n \n\024 1 )Tj -0.028 Tw T* (\030\n)Tj /Span<>> BDC ( )Tj EMC (3, \026)Tj /Span<>> BDC ( )Tj EMC (\t\032\031\030\021\031\031 \027\032\031\003\002 \n\024 \033\n\002\027\023\ \031\021\025\002 \t\025\003\033\024\n\003\n\027 \030\n)Tj /Span<>> BDC ( )Tj EMC (\n\005\032\026\211\031\021\025\002 \013)Tj /Span<>> BDC ( )Tj EMC (\t\033\031\203\025\026\023\025\t\024\205 \t\n\t\024\026\027\025\023\n 39\ \003\031\t\002\203\031\027 \(\032\026\016\005\032\n\t: )Tj 0.045 Tw T* (0\226240)Tj /Span<>> BDC ( )Tj EMC (\003\031\t\002\203\031\027, \003\n\030\026)Tj /Span<>> BDC ( )Tj EMC (\227 24\). \213\020\023\025 \027\020\002\027\023\031\021\020 \030\031\f\031\ \013\024\020 \021\026\032\205\204\021\n\202\n \026\021\026\023\022\021\n\ \202\n \t\f\025\021\013\024\031\032\026 \(\217\201\207\) \t)Tj /Span<>> BDC ( )Tj EMC (\030\025\026\t\024\026\016\n\003 )Tj -0.017 Tw 0 -1.111 TD (\003\020\001\031\006\021\020\004 \027\n\023\n\013\n\021 \n\024 47 \030\n\ )Tj /Span<>> BDC ( )Tj EMC (116 \202\032\026\030\205\t\n\027. \200\025\026\033\026\016\n\021 \032\026\ \016\003\031\032\n\027 \030\031\f\031\013\024\n\027 \027\021\205\024\032\ \031\021\021\031\202\n \026\021\026\023\022\021\n\202\n \t\f\025\021\013\ \024\031\032\026 )Tj 0.098 Tw 0 -1.111 TD (\(\216\201\207\) \t\n\t\024\026\027\025\023 \n\024 76 \030\n)Tj /Span<>> BDC ( )Tj EMC (177 \202\032\026\030\205\t\n\027. \207\032\031\030\021\025\017 \033\031\032\ \025\n\030 \021\026\005\023\007\030\031\021\025\002 \016\026)Tj /Span<>> BDC ( )Tj EMC (\033\026\203\025\031\021\024\013\026\003\025 \t\n\t\024\026\027\025\023 \ 7 \003\031\t\002\203\031\027 )Tj -0.007 Tw T* (\033\032\025)Tj /Span<>> BDC ( )Tj EMC (\003\026\013\t\025\003\026\023\022\021\n\003 \033\031\032\025\n\030\031)Tj /Span<>> BDC ( )Tj EMC (\227 4 \202\n\030\026. \207\032\031\030\021\025\031 \033\n\013\026\016\026\ \024\031\023\025 \024\002\204\031\t\024\025 \026\021\026\023\022\021\n\202\ \n \021\031\030\031\032\204\026\021\025\002 \033\n)Tj /Span<>> BDC ( )Tj EMC (\001\013\026\023\031 Wexner )Tj 0.01 Tw T* [(Incontinence )0.5(Score )0.5(\025)]TJ /Span<>> BDC ( )Tj EMC [(\013\026\006\031\t\024\027\026 )0.5(\204\025\016\021\025 )0.5(\033\n)]TJ /Span<>> BDC ( )Tj EMC [(\001\013\026\023\026\003 )0.5(FIQL )0.5(\025)]TJ /Span<>> BDC ( )Tj EMC [(PISQ-12 )0.5(\030\n)]TJ /Span<>> BDC ( )Tj EMC (\027\003\031\001\026\024\031\023\022\t\024\027\026 \t\n\t\024\026\027\023\ \002\023\025 13 \(SD)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (3,5\), )Tj 0.107 Tw T* (1,9 \(SD)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,5\) \025)Tj /Span<>> BDC ( )Tj EMC (17 \(SD)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (6,8\), \t\n\n\024\027\031\024\t\024\027\031\021\021\n. \n\t\023\031 \023\ \031\006\031\021\025\002 \013\n\023\025\006\031\t\024\027\n \005\026\023\ \023\n\027 \033\n)Tj /Span<>> BDC ( )Tj EMC (\205\013\026\016\026\021\021\020\003 \001\013\026\023\026\003 )Tj 0.063 Tw T* (\t\n\t\024\026\027\025\023\n 2,8 \(SD)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (2,9\), 3,6 \(SD)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,6\), 8,2 \(SD)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (3,5\), \t\n\n\024\027\031\024\t\024\027\031\021\021\n. \222\n\032\032\031\ \023\002\203\025\025 \003\031\204\030\205 \033\n\013\026\016\026\024\031\ \023\002\003\025 )Tj 0.023 Tw T* (\214\221\215 \025)Tj /Span<>> BDC ( )Tj EMC (\032\031\016\205\023\022\024\026\024\026\003\025 \n\203\031\021\013\025 \ \024\002\204\031\t\024\025 \021\031\030\031\032\204\026\021\025\002 \025\ )Tj /Span<>> BDC ( )Tj EMC (\013\026\006\031\t\024\027\026 \204\025\016\021\025 \027\020\002\027\023\ \031\021\n \021\031 \005\020\023\n.)Tj 0.001 Tw T* (\216\235\216\255\200\235: \004\025\032\205\032\202\025\006\031\t\013\n\031\ \023\031\006\031\021\025\031 \033\n\t\023\031\032\n\030\n\027\n\202\n \026\ \021\026\023\022\021\n\202\n \021\031\030\031\032\204\026\021\025\002 \030\ \031\003\n\021\t\024\032\025\032\205\031\024 \027\020\t\n\013\205\007 \r\ \f\f\031\013\024\025\027)Tj 0 Tw (-)Tj 0.043 Tw T* (\021\n\t\024\022 \027\021\031 \016\026\027\025\t\025\003\n\t\024\025 \n\024\ \027\031\023\025\006\025\021\020 \030\031\f\031\013\024\026 \027\021\205\ \024\032\031\021\021\031\202\n \025)Tj /Span<>> BDC ( )Tj EMC (\021\026\032\205\204\021\n\202\n \t\f\025\021\013\024\031\032\n\027 \025\ )Tj /Span<>> BDC ( )Tj EMC (\030\032\205\202\025\004 \026\021\026\024\n\003\025\006\031)Tj 0 Tw (-)Tj 0.002 Tw 0 -1.111 TD (\t\013\025\004 \025\016\003\031\021\031\021\025\017 \003\020\001\031\006\ \021\n\202\n \013\026\032\013\026\t\026, \n\005\205\t\023\n\027\023\031\021\ \021\020\004 \032\n\030\n\027\n\017 \024\032\026\027\003\n\017. \214\023\ \022\024\032\026\016\027\205\013\n\027\026\002 \030\025\026\202\021\n\t\024\ \025\013\026, \005\205\030\205\006\025 )Tj -0.009 Tw 0 -1.111 TD (\021\031\016\026\003\031\021\025\003\020\003 \030\025\026\202\021\n\t\024\ \025\006\031\t\013\025\003 \025\021\t\024\032\205\003\031\021\024\n\003 \ \030\023\002 \033\023\026\021\025\032\n\027\026\021\025\002 \004\025\032\ \205\032\202\025\006\031\t\013\n\017 \032\031\013\n\021\t\024\032\205\013\ \203\025\025, \021\031 \002\027\023\002\031\024)Tj 0 Tw (-)Tj 0.023 Tw T* (\t\002 \033\032\031\030\025\013\024\n\032\n\003 \r\f\f\031\013\024\025\027\ \021\n\t\024\025 \023\031\006\031\021\025\002 \033\n\t\023\031\032\n\030\ \n\027\n\017 \026\021\026\023\022\021\n\017 \025\021\013\n\021\024\025\021\ \031\021\203\025\025.)Tj /T1_2 1 Tf 0.01 Tc 0.118 Tw 8 0 0 8 42.5596 318.3796 Tm [(\037\036\035\034\033\032\031\033)5( \030\036\027\032\026:)]TJ /T1_1 1 Tf 0 Tc 0.123 Tw 8.593 0 Td ( \026\021\026\023\022\021\n\031 \021\031\030\031\032\204\026\021\025\031\ , OASIS, \t\f\025\021\013\024\031\032\n\033\023\026\t\024\025\013\026, \026\ \013\205\001\031\032\t\013\026\002 \024\032\026\027\003\026 \033\032\n\003\ \031\204\021\n\t\024\025, \026\021\026\023\022\021\026\002 \025\021\013\n\ \021\024\025\021\031\021\203\025\002, )Tj 0.023 Tw -8.598 -1.2 Td (3D-\205\023\022\024\032\026\016\027\205\013\n\027\n\031 \025\t\t\023\031\ \030\n\027\026\021\025\031)Tj /T1_2 1 Tf 0.01 Tc 0.018 Tw 0.005 -1.909 Td [(\037\027\025\024\036\023\037\022)5( \023\025\022\033\021\033\030\027\032:)]TJ /T1_1 1 Tf 0 Tc 0.023 Tw 10.401 0 Td ( \026\027\024\n\032\020 \016\026\002\027\023\002\007\024 \n\005 \n\024\t\ \205\024\t\024\027\025\025 \013\n\021\f\023\025\013\024\026 \025\021\024\ \031\032\031\t\n\027)Tj /T1_2 1 Tf 0.022 Tc -0.04 Tw -10.401 -2.617 Td [(\020\036)0.5(\017)5.4( )0.5(\016\023)0.5(\022\023)0.5(\021\027)0.5(\032\026)0.5(\025\023)0.5(\017:)]TJ /T1_3 1 Tf 0.012 Tc -0.035 Tw 8.945 0 Td [( \204\026)0.5(\030\022\026)0.5(\030\034\016)0.5(\027)]TJ /Span<>> BDC ( )Tj EMC [(\212)0.5(.\217)0.5(., \214\031)0.5(\022\034)0.5(\016\027)0.5(\024\r)]TJ /Span<>> BDC ( )Tj EMC [(\202)0.5(.\204.)0.5(, \025\017)0.5(\f\036)0.5(\035\036\r)]TJ /Span<>> BDC 17.087 0 Td ( )Tj EMC [(\212.)0.5(\210.,)0.5( \202\020\026)0.5(\023\024)0.5(\r)]TJ /Span<>> BDC ( )Tj EMC [(\204.\202)0.5(.)0.5( \215)0.5(\030\024\020)0.5(\027\024)0.5( \f\021)0.5(\036\023\036)0.5(\027\017)0.5( \023)0.5(\024\r)0.5(\030\036\032)0.5(\007\036\027)0.5(\017\005)0.5( \021\026)0.5(\024\r\024)0.5(\020\024 \007)0.5(\027\026 \r)]TJ /Span<>> BDC 26.951 0 Td ( )Tj EMC [(\035\036)0.5(\004\036)0.5(\027\017\017)12( )]TJ 0.01 Tc -52.988 -1.2 Td [(\023)0.5(\024\f)0.5(\021)0.5(\021\030)0.5(\026)0.5(\r\n)0.5(\026)0.5(\021\017)0.5(\004)0.5(\036\f)0.5(\022)0.5(\024\020)0.5(\024)0.5( \026\027)0.5(\026)0.5(\035)0.5(\034\027)0.5(\024)0.5(\020\024)0.5( \027)0.5(\036)0.5(\007\036)0.5(\030)0.5(\032\026)0.5(\027)0.5(\017)0.5(\016.)0.5( )]TJ /T1_1 1 Tf -0.01 Tw [(\222)0.5(\n)0.5(\023\n)0.5(\033)0.5(\032)0.5(\n\013)0.5(\024)0.5(\n\023)0.5(\n)0.5(\202)0.5(\025\002)0.5(.)]TJ /T1_3 1 Tf -0.035 Tw 27.256 0 Td [( 2)0.5(02)0.5(4)0.5(; \021)0.5(.)]TJ /Span<>> BDC 3.469 0 Td ( )Tj EMC [(2)0.5(3,)0.5( \225)]TJ /Span<>> BDC 2.477 0 Td ( )Tj EMC [(1)0.5(, )0.5(\f.)]TJ /Span<>> BDC 1.871 0 Td ( )Tj EMC [(7)0.5(1\226)0.5(8)0.5(1.)0.5( h)0.5(tt)0.5(p)0.5(s)0.5(:/)0.5(/)0.5(do)0.5(i)0.5(.o)0.5(r)0.5(g/)0.5(1)0.5(0.)0.5(3)0.5(38)0.5(7)0.5(8/)0.5(20)0.5(7)0.5(3-)0.5(7)0.5(55)0.5(6)0.5(-2)0.5(0)0.5(24)0.5(-)]TJ 0.023 Tc -0.023 Tw -35.073 -1.2 Td (23-1-71-81)Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 0 Tc 0.023 Tw 18 0 0 18 105.83 221.0333 Tm [(Pr)20(ognoses of injur)-30.9(y scale in sur)31(gical tr)31.1(eatment )]TJ 2.091 -1.167 Td [(of post-tr)21.1(aumatic anal incontinence)]TJ 0 0 0 1 k /GS1 gs 0 Tw 14 0 0 14 42.5197 175.5294 Tm [(Daniil\022)-23.2(R.\022)-23.3(Markar)-30.9(y)21(an)]TJ 8.162 0 0 8.162 156.5976 180.1914 Tm (1)Tj 0.023 Tw 14 0 0 14 161.2336 175.5294 Tm [(, Ale\207ander\022)-23.2(M.\022)-23.3(Lukianov)]TJ 0 Tw 8.162 0 0 8.162 300.4314 180.1914 Tm (1)Tj 0.023 Tw 14 0 0 14 305.0674 175.5294 Tm [(, Dmitr)-30.9(y\022)-23.3(O.\022)-23.3(Kisele)11.1(v)]TJ 0 Tw 8.162 0 0 8.162 411.1417 180.1914 Tm (2)Tj 14 0 0 14 415.7776 175.5294 Tm (, )Tj -26.661 -1.143 Td [(Mikhail\022)-23.2(A)-31(.\022)-23.3(Agapov)]TJ 8.162 0 0 8.162 149.6401 164.1914 Tm (3)Tj 5.83 0 0 5.83 42.5197 145.1901 Tm (1)Tj 0.023 Tw 10 0 0 10 45.8311 141.8601 Tm [(Lomonosov Moscow State Univ)12.1(er)20(sit)-20(y \(Leninskie Gor)-31(y\022)-23.3(st., 1)69(, Moscow)22(, 1)212(1)138(999)125(1)69(, Russia\))]TJ 0 Tw ( )Tj 5.83 0 0 5.83 42.5197 133.1901 Tm (2)Tj 0.023 Tw 10 0 0 10 45.8311 129.8601 Tm [(R)20(y)21(zhikh National Medical Resear)31(ch Center of Colopr)20.1(octology \(Saly)21(ama Adily)21(a\022)-23.3(st., 2, Moscow)22(, Russia\))]TJ 0 Tw ( )Tj 5.83 0 0 5.83 42.5197 121.1902 Tm (3)Tj 0.023 Tw 10 0 0 10 45.8311 117.8602 Tm [(Immanuel K)41(ant Baltic F)19.9(eder)21.1(al Univ)12(er)20(sit)-19.9(y \(Ne)11(v)10(sk)11(ogo\022)-23.3(st., 1)150(4 A)-31(, K)41(aliningr)21.1(ad, 2360)87(1)112.1(6, Russia\))]TJ /T1_1 1 Tf -0.016 Tw 9 0 0 9 90.7087 99.3562 Tm [(AIM: )0.5(to ev)16(aluate )0.5(the p)46(redictiv)13.1(e v)16(alue of )0.5(endorectal )0.5(ultrasound )0.6(\(ER)27(US\) )0.5(and transper)-37(ineal )0.5(ultrasound \(TPUS\) in )0.5(surgi)]TJ 0 Tw (-)Tj 0.023 Tw T* (cal treatment of post-traumatic anal incontinence \(AI\).)Tj ET 1 0.68 0 0.12 k /GS0 gs q 1 0 0 1 42.5197 562.1533 cm 0 0 m 0 0 l 0 -11.339 l 42.52 -11.339 l 42.52 0 l h f Q BT 0 0 0 0 k /T1_2 1 Tf 0 Tw 9 0 0 9 47.6607 553.226 Tm (\021\033\r\035\f\033)Tj ET 1 0.68 0 0.12 k q 1 0 0 1 42.5197 107.8604 cm 0 0 m 0 0 l 0 -11.339 l 42.52 -11.339 l 42.52 0 l h f Q BT 0 0 0 0 k /T1_2 1 Tf 9 0 0 9 45.2263 98.9331 Tm (ABSTRACT)Tj 1 0.68 0 0.12 k /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\033\030\031\030\213\b)-20.9(\035\231\213\233\t \021\032)50(\b)42(\032\231\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj /T1_4 1 Tf 25 0 0 25 512.0519 56.0378 Tm (71)Tj ET q 0 g 0 G 0 j 0 J /Fm1 Do Q 0 0 0 0 k 368.504 725.67 59.155 11.338 re f /PlacedPDF /MC0 BDC q 369.135 736.808 m 368.896 736.808 368.703 736.616 368.703 736.376 c 368.703 736.376 l 368.703 726.285 l 368.703 726.045 368.896 725.853 369.135 725.853 c 369.135 725.853 l 427.035 725.853 l 427.273 725.853 427.469 726.045 427.469 726.285 c 427.469 726.285 l 427.469 736.376 l 427.469 736.616 427.273 736.808 427.035 736.808 c 427.035 736.808 l h W n q 0 g -0.0000005 -10.9560913 -10.9560913 0.0000005 398.0855785 736.8086309 cm BX /Sh0 sh EX Q Q q 368.504 725.67 59.155 11.337 re W n 0 0 0 0.84 k q 1 0 0 1 385.2169 732.4249 cm 0 0 m -0.025 0.1 -0.063 0.196 -0.112 0.287 c -0.157 0.374 -0.218 0.451 -0.292 0.515 c -0.37 0.582 -0.46 0.632 -0.558 0.664 c -0.669 0.701 -0.786 0.719 -0.903 0.717 c -1.076 0.722 -1.247 0.681 -1.4 0.6 c -1.536 0.526 -1.652 0.42 -1.74 0.292 c -1.83 0.158 -1.895 0.008 -1.934 -0.149 c -2.018 -0.48 -2.018 -0.827 -1.934 -1.158 c -1.896 -1.316 -1.83 -1.466 -1.74 -1.602 c -1.653 -1.731 -1.536 -1.837 -1.4 -1.912 c -1.247 -1.993 -1.076 -2.033 -0.903 -2.029 c -0.774 -2.032 -0.647 -2.006 -0.528 -1.955 c -0.427 -1.906 -0.337 -1.837 -0.263 -1.753 c -0.185 -1.665 -0.124 -1.563 -0.082 -1.453 c -0.034 -1.338 0 -1.218 0.019 -1.094 c 0.635 -1.094 l 0.624 -1.297 0.578 -1.497 0.497 -1.684 c 0.421 -1.857 0.312 -2.015 0.175 -2.146 c 0.039 -2.277 -0.123 -2.379 -0.3 -2.446 c -0.492 -2.519 -0.695 -2.555 -0.9 -2.552 c -1.15 -2.557 -1.397 -2.506 -1.625 -2.404 c -1.829 -2.307 -2.01 -2.169 -2.157 -1.997 c -2.308 -1.821 -2.423 -1.617 -2.497 -1.397 c -2.655 -0.924 -2.655 -0.412 -2.497 0.061 c -2.423 0.281 -2.307 0.485 -2.157 0.661 c -2.01 0.833 -1.829 0.973 -1.625 1.07 c -1.398 1.174 -1.15 1.226 -0.9 1.222 c -0.707 1.223 -0.515 1.196 -0.329 1.14 c -0.159 1.088 0.001 1.006 0.144 0.898 c 0.278 0.793 0.39 0.662 0.473 0.513 c 0.562 0.349 0.615 0.167 0.629 -0.019 c 0 -0.019 l 0 0 l f Q q 1 0 0 1 386.3458 733.5723 cm 0 0 m 0.584 0 l 0.584 -1.328 l 0.662 -1.204 0.771 -1.103 0.9 -1.033 c 1.046 -0.951 1.213 -0.91 1.381 -0.914 c 1.627 -0.9 1.869 -0.979 2.058 -1.137 c 2.234 -1.312 2.325 -1.556 2.305 -1.803 c 2.305 -3.596 l 1.716 -3.596 l 1.716 -1.976 l 1.724 -1.817 1.678 -1.66 1.585 -1.53 c 1.486 -1.43 1.347 -1.379 1.206 -1.392 c 1.114 -1.39 1.024 -1.408 0.94 -1.445 c 0.865 -1.479 0.798 -1.529 0.744 -1.591 c 0.687 -1.656 0.645 -1.73 0.616 -1.812 c 0.586 -1.896 0.571 -1.986 0.571 -2.077 c 0.571 -3.615 l 0 -3.615 l 0 0 l f Q q 1 0 0 1 389.692 731.1235 cm 0 0 m 0 -0.099 0.014 -0.198 0.043 -0.292 c 0.069 -0.382 0.112 -0.466 0.17 -0.54 c 0.229 -0.611 0.304 -0.669 0.388 -0.709 c 0.486 -0.754 0.594 -0.776 0.702 -0.773 c 0.845 -0.78 0.987 -0.742 1.108 -0.664 c 1.217 -0.582 1.296 -0.468 1.336 -0.337 c 1.881 -0.337 l 1.827 -0.603 1.675 -0.838 1.456 -0.996 c 1.35 -1.073 1.231 -1.131 1.105 -1.169 c 0.971 -1.208 0.831 -1.229 0.691 -1.227 c 0.509 -1.227 0.328 -1.191 0.16 -1.121 c 0.007 -1.063 -0.13 -0.972 -0.244 -0.855 c -0.356 -0.73 -0.44 -0.583 -0.491 -0.422 c -0.548 -0.243 -0.576 -0.056 -0.574 0.133 c -0.575 0.313 -0.545 0.493 -0.486 0.664 c -0.426 0.826 -0.335 0.974 -0.22 1.102 c 0.004 1.375 0.338 1.534 0.691 1.535 c 0.883 1.539 1.072 1.495 1.243 1.408 c 1.402 1.326 1.541 1.209 1.649 1.067 c 1.759 0.922 1.838 0.757 1.883 0.582 c 1.932 0.396 1.945 0.203 1.92 0.013 c 0 0.013 l 0 0 l 1.342 0.377 m 1.335 0.468 1.315 0.557 1.283 0.643 c 1.253 0.724 1.209 0.798 1.153 0.863 c 1.097 0.922 1.03 0.97 0.957 1.004 c 0.874 1.043 0.783 1.063 0.691 1.062 c 0.6 1.062 0.509 1.044 0.425 1.009 c 0.345 0.976 0.273 0.926 0.213 0.863 c 0.153 0.799 0.105 0.724 0.072 0.643 c 0.037 0.559 0.017 0.468 0.014 0.377 c 1.355 0.377 l h f Q q 1 0 0 1 393.8116 731.7051 cm 0 0 m -0.012 0.144 -0.082 0.276 -0.194 0.366 c -0.31 0.452 -0.451 0.495 -0.595 0.489 c -0.675 0.488 -0.755 0.476 -0.831 0.452 c -0.918 0.424 -0.998 0.375 -1.062 0.311 c -1.142 0.229 -1.202 0.131 -1.24 0.024 c -1.29 -0.132 -1.312 -0.296 -1.304 -0.459 c -1.304 -0.569 -1.292 -0.677 -1.267 -0.784 c -1.244 -0.885 -1.202 -0.983 -1.145 -1.07 c -1.09 -1.154 -1.016 -1.224 -0.93 -1.275 c -0.833 -1.33 -0.722 -1.356 -0.611 -1.352 c -0.457 -1.357 -0.307 -1.301 -0.194 -1.195 c -0.078 -1.077 -0.005 -0.922 0.011 -0.757 c 0.587 -0.757 l 0.556 -1.055 0.419 -1.332 0.202 -1.538 c -0.022 -1.721 -0.306 -1.815 -0.595 -1.803 c -0.777 -1.806 -0.958 -1.771 -1.126 -1.7 c -1.293 -1.642 -1.445 -1.547 -1.57 -1.421 c -1.68 -1.297 -1.763 -1.151 -1.814 -0.993 c -1.87 -0.822 -1.898 -0.643 -1.896 -0.462 c -1.898 -0.276 -1.871 -0.091 -1.817 0.087 c -1.766 0.252 -1.682 0.405 -1.57 0.537 c -1.459 0.664 -1.323 0.766 -1.168 0.834 c -0.991 0.914 -0.798 0.955 -0.603 0.954 c -0.457 0.954 -0.311 0.935 -0.17 0.895 c -0.039 0.858 0.084 0.799 0.194 0.72 c 0.302 0.643 0.393 0.543 0.459 0.428 c 0.531 0.298 0.572 0.155 0.582 0.008 c 0 0.008 l 0 0 l f Q q 1 0 0 1 394.8712 733.5723 cm 0 0 m 0.577 0 l 0.577 -2.048 l 1.615 -0.985 l 2.322 -0.985 l 1.323 -1.944 l 2.417 -3.604 l 1.716 -3.604 l 0.919 -2.337 l 0.577 -2.669 l 0.577 -3.604 l 0 -3.604 l h f Q q 1 0 0 1 398.712 732.5762 cm 0 0 m 0.436 0 l 0.436 0.218 l 0.429 0.352 0.448 0.486 0.488 0.614 c 0.521 0.705 0.577 0.786 0.651 0.85 c 0.717 0.905 0.795 0.943 0.879 0.961 c 0.966 0.979 1.056 0.988 1.145 0.988 c 1.28 0.993 1.416 0.981 1.548 0.954 c 1.548 0.505 l 1.509 0.516 1.469 0.523 1.429 0.528 c 1.379 0.532 1.33 0.532 1.28 0.528 c 1.209 0.53 1.14 0.511 1.081 0.473 c 1.019 0.419 0.987 0.337 0.999 0.255 c 0.999 -0.011 l 1.498 -0.011 l 1.498 -0.441 l 1.009 -0.441 l 1.009 -2.622 l 0.436 -2.622 l 0.436 -0.428 l 0.005 -0.428 l 0.005 0 l 0 0 l f Q q 1 0 0 1 401.7535 729.8965 cm 0 0 m -0.191 -0.003 -0.381 0.032 -0.559 0.104 c -0.715 0.167 -0.856 0.264 -0.972 0.388 c -1.091 0.512 -1.181 0.659 -1.238 0.82 c -1.356 1.18 -1.356 1.567 -1.238 1.925 c -1.181 2.087 -1.091 2.234 -0.972 2.358 c -0.856 2.481 -0.715 2.578 -0.559 2.643 c -0.199 2.78 0.198 2.78 0.558 2.643 c 0.714 2.578 0.855 2.481 0.972 2.358 c 1.09 2.234 1.181 2.087 1.237 1.925 c 1.355 1.567 1.355 1.18 1.237 0.82 c 1.181 0.659 1.09 0.512 0.972 0.388 c 0.855 0.266 0.713 0.169 0.558 0.106 c 0.38 0.034 0.191 -0.002 0 0 c 0 0.454 m 0.115 0.451 0.23 0.479 0.332 0.534 c 0.424 0.586 0.502 0.659 0.562 0.746 c 0.624 0.836 0.669 0.936 0.695 1.041 c 0.752 1.26 0.752 1.491 0.695 1.71 c 0.669 1.816 0.625 1.916 0.562 2.005 c 0.502 2.091 0.423 2.163 0.332 2.215 c 0.123 2.323 -0.126 2.323 -0.335 2.215 c -0.427 2.163 -0.505 2.091 -0.566 2.005 c -0.628 1.916 -0.673 1.816 -0.699 1.71 c -0.756 1.491 -0.756 1.26 -0.699 1.041 c -0.672 0.936 -0.627 0.836 -0.566 0.746 c -0.506 0.659 -0.427 0.586 -0.335 0.534 c -0.232 0.478 -0.117 0.451 0 0.454 c f Q q 1 0 0 1 403.5515 732.5762 cm 0 0 m 0.531 0 l 0.531 -0.505 l 0.55 -0.43 0.583 -0.359 0.629 -0.297 c 0.681 -0.229 0.74 -0.167 0.807 -0.114 c 0.877 -0.059 0.956 -0.014 1.039 0.019 c 1.123 0.053 1.213 0.07 1.304 0.069 c 1.52 0.069 l 1.52 -0.486 l 1.395 -0.467 l 1.269 -0.467 l 1.178 -0.468 1.087 -0.488 1.004 -0.526 c 0.917 -0.565 0.839 -0.625 0.778 -0.699 c 0.716 -0.783 0.669 -0.878 0.643 -0.98 c 0.604 -1.104 0.584 -1.233 0.586 -1.362 c 0.586 -2.603 l 0.01 -2.603 l 0.01 0 l 0 0 l f Q q 1 0 0 1 409.0202 729.9683 cm 0 0 m -0.577 0 l -0.577 0.364 l -0.649 0.23 -0.759 0.121 -0.893 0.047 c -1.022 -0.029 -1.169 -0.07 -1.32 -0.072 c -1.595 -0.095 -1.866 0.002 -2.064 0.194 c -2.234 0.413 -2.316 0.687 -2.295 0.964 c -2.295 2.608 l -1.719 2.608 l -1.719 1.014 l -1.735 0.843 -1.689 0.67 -1.588 0.531 c -1.492 0.433 -1.357 0.382 -1.219 0.39 c -1.116 0.387 -1.012 0.406 -0.917 0.446 c -0.84 0.479 -0.772 0.531 -0.72 0.595 c -0.667 0.661 -0.63 0.738 -0.611 0.82 c -0.588 0.911 -0.577 1.003 -0.577 1.097 c -0.577 2.611 l 0 2.611 l 0 0 l f Q q 1 0 0 1 409.6413 732.5762 cm 0 0 m 0.545 0 l 0.545 -0.353 l 0.617 -0.209 0.736 -0.094 0.882 -0.026 c 1.03 0.04 1.19 0.073 1.352 0.072 c 1.535 0.075 1.717 0.038 1.883 -0.037 c 2.031 -0.106 2.161 -0.208 2.263 -0.334 c 2.366 -0.465 2.442 -0.615 2.489 -0.775 c 2.54 -0.948 2.566 -1.127 2.566 -1.307 c 2.566 -1.479 2.542 -1.651 2.497 -1.817 c 2.455 -1.973 2.385 -2.121 2.29 -2.252 c 2.099 -2.522 1.789 -2.682 1.458 -2.68 c 1.369 -2.681 1.28 -2.674 1.193 -2.659 c 1.11 -2.644 1.028 -2.618 0.951 -2.584 c 0.875 -2.552 0.802 -2.509 0.736 -2.457 c 0.671 -2.406 0.615 -2.343 0.571 -2.273 c 0.571 -3.575 l -0.005 -3.575 l -0.005 0 l 0 0 l 2.008 -1.307 m 2.008 -1.191 1.993 -1.076 1.963 -0.964 c 1.936 -0.859 1.89 -0.759 1.828 -0.669 c 1.768 -0.584 1.69 -0.514 1.599 -0.462 c 1.503 -0.409 1.395 -0.382 1.286 -0.385 c 1.072 -0.372 0.867 -0.467 0.738 -0.638 c 0.607 -0.836 0.543 -1.072 0.555 -1.31 c 0.554 -1.433 0.57 -1.557 0.603 -1.676 c 0.631 -1.781 0.68 -1.879 0.747 -1.965 c 0.809 -2.044 0.886 -2.109 0.975 -2.157 c 1.071 -2.206 1.178 -2.23 1.286 -2.229 c 1.401 -2.232 1.517 -2.205 1.618 -2.148 c 1.708 -2.096 1.785 -2.025 1.843 -1.939 c 1.903 -1.85 1.945 -1.751 1.968 -1.646 c 1.995 -1.535 2.008 -1.421 2.008 -1.307 c f Q q 1 0 0 1 415.1662 729.9683 cm 0 0 m -0.545 0 l -0.545 0.353 l -0.616 0.211 -0.734 0.099 -0.879 0.034 c -1.027 -0.031 -1.187 -0.065 -1.349 -0.064 c -1.532 -0.067 -1.714 -0.03 -1.88 0.045 c -2.028 0.113 -2.158 0.214 -2.26 0.34 c -2.364 0.47 -2.441 0.62 -2.486 0.781 c -2.538 0.958 -2.564 1.143 -2.563 1.328 c -2.568 1.536 -2.536 1.742 -2.468 1.938 c -2.41 2.097 -2.319 2.242 -2.202 2.364 c -2.101 2.471 -1.977 2.555 -1.838 2.608 c -1.705 2.659 -1.563 2.685 -1.421 2.685 c -1.338 2.685 -1.256 2.678 -1.174 2.664 c -1.091 2.648 -1.01 2.624 -0.932 2.589 c -0.855 2.556 -0.783 2.514 -0.717 2.462 c -0.652 2.411 -0.597 2.349 -0.553 2.279 c -0.553 3.606 l 0.024 3.606 l 0.024 0 l 0 0 l -2.008 1.277 m -2.009 1.166 -1.994 1.056 -1.965 0.948 c -1.939 0.845 -1.896 0.748 -1.835 0.661 c -1.777 0.578 -1.699 0.508 -1.61 0.459 c -1.404 0.355 -1.162 0.355 -0.956 0.459 c -0.866 0.512 -0.789 0.585 -0.73 0.671 c -0.671 0.762 -0.626 0.862 -0.6 0.966 c -0.572 1.076 -0.558 1.188 -0.558 1.301 c -0.543 1.542 -0.612 1.781 -0.751 1.979 c -0.88 2.14 -1.078 2.229 -1.283 2.22 c -1.402 2.224 -1.52 2.196 -1.623 2.138 c -1.714 2.083 -1.793 2.009 -1.852 1.92 c -1.911 1.828 -1.954 1.725 -1.977 1.617 c -1.999 1.505 -2.01 1.392 -2.008 1.277 c f Q q 1 0 0 1 417.9787 730.5499 cm 0 0 m -0.004 -0.052 0.005 -0.104 0.026 -0.151 c 0.052 -0.185 0.094 -0.202 0.136 -0.197 c 0.197 -0.197 l 0.223 -0.2 0.25 -0.2 0.276 -0.197 c 0.276 -0.595 l 0.199 -0.619 l 0.101 -0.64 l 0 -0.656 l -0.085 -0.656 l -0.187 -0.66 -0.288 -0.635 -0.377 -0.584 c -0.461 -0.528 -0.516 -0.437 -0.528 -0.337 c -0.648 -0.451 -0.792 -0.534 -0.951 -0.579 c -1.106 -0.628 -1.269 -0.654 -1.432 -0.656 c -1.546 -0.657 -1.659 -0.641 -1.769 -0.608 c -1.872 -0.579 -1.967 -0.531 -2.053 -0.468 c -2.136 -0.405 -2.203 -0.324 -2.25 -0.231 c -2.3 -0.127 -2.326 -0.012 -2.324 0.104 c -2.33 0.24 -2.299 0.375 -2.236 0.497 c -2.181 0.594 -2.101 0.675 -2.005 0.733 c -1.905 0.791 -1.795 0.833 -1.681 0.855 c -1.562 0.88 -1.442 0.899 -1.32 0.914 c -1.222 0.933 -1.123 0.947 -1.022 0.956 c -0.938 0.963 -0.855 0.977 -0.773 0.999 c -0.708 1.014 -0.649 1.046 -0.6 1.092 c -0.556 1.144 -0.533 1.211 -0.536 1.28 c -0.534 1.344 -0.553 1.408 -0.59 1.46 c -0.624 1.507 -0.668 1.544 -0.72 1.569 c -0.775 1.596 -0.834 1.613 -0.895 1.62 c -0.955 1.624 -1.016 1.624 -1.076 1.62 c -1.215 1.625 -1.354 1.591 -1.474 1.519 c -1.581 1.45 -1.647 1.333 -1.652 1.206 c -2.231 1.206 l -2.227 1.354 -2.185 1.498 -2.108 1.625 c -2.041 1.733 -1.951 1.824 -1.843 1.891 c -1.729 1.96 -1.603 2.007 -1.472 2.032 c -1.329 2.072 -1.183 2.098 -1.036 2.109 c -0.908 2.109 -0.781 2.096 -0.656 2.069 c -0.538 2.044 -0.425 2 -0.321 1.939 c -0.225 1.88 -0.143 1.8 -0.083 1.705 c -0.02 1.599 0.012 1.478 0.008 1.354 c 0.008 0.013 l 0 0 l -0.576 0.728 m -0.674 0.667 -0.785 0.631 -0.9 0.624 c -1.028 0.612 -1.155 0.594 -1.283 0.571 c -1.343 0.561 -1.402 0.547 -1.46 0.528 c -1.515 0.511 -1.566 0.485 -1.612 0.451 c -1.657 0.419 -1.692 0.376 -1.716 0.327 c -1.742 0.267 -1.755 0.203 -1.753 0.138 c -1.755 0.079 -1.735 0.021 -1.697 -0.024 c -1.661 -0.067 -1.615 -0.103 -1.564 -0.127 c -1.509 -0.154 -1.451 -0.171 -1.392 -0.181 c -1.335 -0.19 -1.278 -0.196 -1.222 -0.197 c -1.152 -0.196 -1.083 -0.188 -1.015 -0.173 c -0.94 -0.156 -0.87 -0.127 -0.805 -0.088 c -0.74 -0.048 -0.684 0.004 -0.64 0.066 c -0.594 0.134 -0.571 0.215 -0.574 0.297 c -0.574 0.725 l h f Q q 1 0 0 1 418.3371 732.5762 cm 0 0 m 0.434 0 l 0.434 0.784 l 0.996 0.784 l 0.996 0 l 1.527 0 l 1.527 -0.43 l 0.996 -0.43 l 0.996 -1.822 l 0.993 -1.874 0.993 -1.927 0.996 -1.979 c 1 -2.018 1.011 -2.056 1.031 -2.09 c 1.05 -2.122 1.079 -2.146 1.113 -2.159 c 1.162 -2.177 1.213 -2.185 1.265 -2.183 c 1.387 -2.183 l 1.428 -2.181 1.469 -2.175 1.509 -2.165 c 1.509 -2.608 l 1.323 -2.629 l 1.261 -2.633 1.199 -2.633 1.137 -2.629 c 1.013 -2.633 0.89 -2.619 0.771 -2.587 c 0.688 -2.564 0.613 -2.52 0.553 -2.459 c 0.499 -2.4 0.462 -2.328 0.446 -2.25 c 0.427 -2.155 0.416 -2.059 0.415 -1.963 c 0.415 -0.428 l -0.019 -0.428 l -0.019 0 l 0 0 l f Q q 1 0 0 1 420.7277 731.1235 cm 0 0 m 0 -0.099 0.014 -0.198 0.042 -0.292 c 0.068 -0.382 0.112 -0.466 0.17 -0.54 c 0.229 -0.611 0.303 -0.669 0.388 -0.709 c 0.486 -0.754 0.593 -0.776 0.701 -0.773 c 0.845 -0.78 0.987 -0.742 1.107 -0.664 c 1.216 -0.582 1.296 -0.468 1.336 -0.337 c 1.88 -0.337 l 1.827 -0.603 1.674 -0.838 1.456 -0.996 c 1.349 -1.073 1.231 -1.131 1.105 -1.169 c 0.973 -1.208 0.836 -1.228 0.699 -1.227 c 0.512 -1.23 0.327 -1.196 0.154 -1.126 c 0.003 -1.066 -0.133 -0.973 -0.244 -0.855 c -0.356 -0.73 -0.44 -0.583 -0.491 -0.422 c -0.548 -0.243 -0.576 -0.056 -0.574 0.133 c -0.575 0.313 -0.546 0.493 -0.486 0.664 c -0.426 0.826 -0.336 0.974 -0.221 1.102 c 0.002 1.374 0.334 1.532 0.685 1.535 c 0.877 1.539 1.067 1.495 1.238 1.408 c 1.396 1.326 1.535 1.209 1.644 1.067 c 1.753 0.922 1.833 0.757 1.878 0.582 c 1.927 0.396 1.939 0.203 1.915 0.013 c -0.002 0.013 l 0 0 l 1.341 0.377 m 1.335 0.468 1.315 0.557 1.283 0.643 c 1.253 0.724 1.209 0.798 1.153 0.863 c 1.096 0.926 1.027 0.978 0.951 1.014 c 0.868 1.054 0.777 1.074 0.685 1.073 c 0.594 1.073 0.504 1.055 0.419 1.02 c 0.339 0.986 0.267 0.937 0.207 0.874 c 0.147 0.81 0.099 0.735 0.066 0.653 c 0.031 0.569 0.011 0.479 0.008 0.388 c 1.349 0.388 l h f Q q 1 0 0 1 423.5192 730.7994 cm 0 0 m 0.002 -0.142 0.073 -0.274 0.191 -0.353 c 0.312 -0.423 0.45 -0.458 0.59 -0.454 c 0.651 -0.458 0.711 -0.458 0.773 -0.454 c 0.839 -0.447 0.904 -0.43 0.967 -0.406 c 1.024 -0.385 1.075 -0.349 1.116 -0.303 c 1.155 -0.252 1.174 -0.189 1.168 -0.125 c 1.166 -0.057 1.138 0.008 1.089 0.056 c 1.033 0.107 0.967 0.146 0.895 0.17 c 0.809 0.201 0.72 0.226 0.629 0.245 c 0.329 0.33 l 0.224 0.352 0.121 0.38 0.019 0.415 c -0.076 0.446 -0.166 0.491 -0.247 0.55 c -0.327 0.608 -0.391 0.683 -0.436 0.771 c -0.486 0.873 -0.511 0.986 -0.507 1.1 c -0.512 1.226 -0.475 1.351 -0.404 1.456 c -0.333 1.551 -0.243 1.63 -0.138 1.687 c -0.028 1.747 0.092 1.788 0.215 1.809 c 0.337 1.832 0.462 1.843 0.587 1.843 c 0.716 1.844 0.845 1.83 0.972 1.801 c 1.09 1.774 1.202 1.727 1.304 1.663 c 1.404 1.598 1.488 1.513 1.551 1.413 c 1.621 1.3 1.663 1.173 1.676 1.041 c 1.076 1.041 l 1.059 1.155 0.989 1.253 0.887 1.307 c 0.78 1.355 0.665 1.38 0.547 1.378 c 0.5 1.381 0.452 1.381 0.403 1.378 c 0.35 1.373 0.298 1.36 0.247 1.341 c 0.2 1.325 0.157 1.297 0.122 1.262 c 0.087 1.224 0.069 1.174 0.071 1.124 c 0.069 1.058 0.096 0.995 0.146 0.951 c 0.202 0.903 0.267 0.866 0.337 0.842 c 0.424 0.811 0.512 0.786 0.603 0.768 c 0.917 0.701 l 1.021 0.678 1.124 0.65 1.224 0.616 c 1.319 0.584 1.409 0.539 1.49 0.481 c 1.662 0.359 1.762 0.16 1.755 -0.05 c 1.76 -0.189 1.723 -0.326 1.649 -0.443 c 1.582 -0.551 1.491 -0.642 1.384 -0.709 c 1.267 -0.778 1.14 -0.827 1.007 -0.855 c 0.873 -0.885 0.735 -0.9 0.598 -0.9 c 0.443 -0.902 0.29 -0.883 0.141 -0.845 c 0.01 -0.812 -0.114 -0.753 -0.223 -0.674 c -0.324 -0.601 -0.407 -0.504 -0.465 -0.393 c -0.527 -0.269 -0.559 -0.131 -0.558 0.008 c 0.019 0.008 l 0 0 l f Q 0.146 0.941 0.992 0.044 k q 1 0 0 1 372.9062 729.3892 cm 0 0 m 3.612 2.406 l 3.612 5.296 l 0 5.296 l h f Q 0 0.889 0.676 0 k q 1 0 0 1 376.5186 729.3892 cm 0 0 m -3.612 2.406 l -3.612 5.296 l 0 5.296 l h f Q 0.694 0.076 0.209 0 k q 1 0 0 1 374.7125 735.3145 cm 0 0 m -2.2 0 -3.984 -1.784 -3.984 -3.984 c -3.984 -6.184 -2.2 -7.968 0 -7.968 c 2.2 -7.968 3.984 -6.184 3.984 -3.984 c 3.984 -1.784 2.2 0 0 0 c 0 -6.993 m -1.662 -6.993 -3.009 -5.646 -3.009 -3.984 c -3.009 -2.322 -1.662 -0.975 0 -0.975 c 1.662 -0.975 3.009 -2.322 3.009 -3.984 c 3.009 -5.646 1.662 -6.993 0 -6.993 c f Q 0 0.235 0.86 0 k q 1 0 0 1 376.9137 729.2803 cm 0 0 m -1.118 -1.208 -3.015 -1.281 -4.237 -0.159 c -5.159 0.688 -5.459 2.005 -4.999 3.156 c -5.833 3.687 l -6.736 1.681 -5.843 -0.679 -3.836 -1.582 c -2.218 -2.311 -0.312 -1.881 0.836 -0.528 c 0 0 l f Q 0 0 0 0.6 k q 1 0 0 1 369.1348 736.8087 cm 0 0 m -0.238 0 -0.432 -0.193 -0.432 -0.432 c -0.432 -10.524 l -0.432 -10.763 -0.238 -10.956 0 -10.956 c 57.901 -10.956 l 58.139 -10.956 58.333 -10.763 58.333 -10.524 c 58.333 -0.432 l 58.333 -0.193 58.139 0 57.901 0 c h 57.901 -11.155 m 0 -11.155 l -0.348 -11.155 -0.631 -10.872 -0.631 -10.524 c -0.631 -0.432 l -0.631 -0.084 -0.348 0.199 0 0.199 c 57.901 0.199 l 58.249 0.199 58.532 -0.084 58.532 -0.432 c 58.532 -10.524 l 58.532 -10.872 58.249 -11.155 57.901 -11.155 c f Q EMC Q endstream endobj 1851 0 obj <> endobj 1869 0 obj <>stream Adobe Illustrator CS6 (Windows) 2021-04-12T11:45:36+05:00 2021-06-02T10:28:09+05:00 2021-06-02T10:28:09+05:00 1 False False 20.868494 3.999928 Millimeters Cyan Magenta Yellow Black Default Swatch Group 0 C=0 M=24 Y=86 K=0 PROCESS 100.000000 CMYK 0.000000 23.504999 86.022697 0.000000 C=69 M=8 Y=21 K=0 PROCESS 100.000000 CMYK 69.369003 7.635600 20.892700 0.000000 C=0 M=89 Y=68 K=0 PROCESS 100.000000 CMYK 0.000000 88.946404 67.623398 0.000000 C=15 M=94 Y=99 K=4 PROCESS 100.000000 CMYK 14.578501 94.070297 99.160698 4.416000 C=0 M=0 Y=0 K=84 PROCESS 100.000000 CMYK 0.000000 0.000000 0.000000 84.000000 C=0 M=0 Y=0 K=35 PROCESS 100.000000 CMYK 0.000000 0.000000 0.000000 35.000000 C=0 M=0 Y=0 K=60 PROCESS 100.000000 CMYK 0.000000 0.000000 0.000000 60.000004 Document application/pdf proof:pdf xmp.did:804244B35A9BEB118A6FC3C256996E2F uuid:08e30110-bdb7-4606-97ca-63fb62cbcecc uuid:21079f76-f6d7-4329-b725-f2fb35af5114 uuid:722f8893-0b3c-4402-87fb-c713f1fa0e26 uuid:21079f76-f6d7-4329-b725-f2fb35af5114 uuid:21079f76-f6d7-4329-b725-f2fb35af5114 proof:pdf saved xmp.iid:804244B35A9BEB118A6FC3C256996E2F 2021-04-12T11:45:42+05:00 Adobe Illustrator CS6 (Windows) / endstream endobj 1868 0 obj <>/Border[0 0 0]/H/N/Rect[366.504 739.008 429.659 723.67]/Subtype/Link/Type/Annot>> endobj 1870 0 obj <> endobj 1839 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1840 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1841 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1842 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1843 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1876 0 obj [1878 0 R 1879 0 R 1880 0 R 1881 0 R 1882 0 R 1883 0 R 1884 0 R 1885 0 R 1886 0 R 1887 0 R] endobj 1877 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.025 Tw 8 0 0 8 70.8661 731.2159 Tm (2.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Must)15(af)16(a)]TJ /Span<>> BDC ( )Tj EMC 3.393 0 Td [(CT, )0.5(Cihan)]TJ /Span<>> BDC ( )Tj EMC 3.875 0 Td [(A, )0.5(e)-12(t)]TJ /Span<>> BDC ( )Tj EMC 2.085 0 Td [(al. )0.5(Cl)30(osing )0.6(P)30(er)-37(ianal )0.6(F)-19(istul)-16(as )0.6(Using )0.5(a )0.5(L)-31.9(aser: )]TJ 0.044 Tw -10.649 -1.25 Td [(L)35(ong-T)40(er)-16(m R)13(esul)56(ts in 103 P)40(a)15(t)-32(ients. )]TJ /T1_1 1 Tf [(Dis Colon R)21(ectum. )]TJ /T1_0 1 Tf 0 Tw (2018;61:5:00\226)Tj 0.023 Tw 0 -1.25 TD [(00. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1097/DCR.0000000000001038)Tj 0 0 0 1 k /GS1 gs 0.134 Tw T* (3.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(W)-16(ilhelm)]TJ /Span<>> BDC ( )Tj EMC [(A, F)-19(iebig)]TJ /Span<>> BDC ( )Tj EMC [(A, Kr)-32.9(a)10(wezak)]TJ /Span<>> BDC ( )Tj EMC [(M. F)-19(i)-16(ve year)-10(s of e)-18(xper)-36.9(ience wi)-24(t)-13(h )]TJ 0.272 Tw -1.296 -1.25 Td [(t)-13(he F)-19(iL)-32(aC l)-16(aser for f)-28(istul)-16(a-in-ano mana)-17(gement l)30(ong-ter)-16(m foll)30(o)-14(w-)]TJ 0.244 Tw T* [(up )0.6(fr)-32(om )0.6(a )0.5(single )0.6(inst)-32(i)-23.9(tut)-32(ion. )]TJ /T1_1 1 Tf 12.883 0 Td [(T)54(ech )0.6(Colop)46(roctol)]TJ /T1_0 1 Tf [(. )0.5(2017;21:269\226276. )]TJ 0 Tw -12.883 -1.25 Td [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1007/s10151-017-1599-7)Tj 0 0 0 1 k /GS1 gs 0.178 Tw -1.847 -1.25 Td (4.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Z)10(akhar)-37(ian)]TJ /Span<>> BDC ( )Tj EMC 4.349 0 Td [(A.V., )0.6(K)25(ost)15(ar)-24(ev)]TJ /Span<>> BDC ( )Tj EMC 6.084 0 Td [(I.V., )0.6(Bl)-16(a)-17(god)42(ar)-15(ny)]TJ /Span<>> BDC ( )Tj EMC 6.988 0 Td [(L.A., )0.6(e)-12(t)]TJ /Span<>> BDC ( )Tj EMC 3.427 0 Td [(al. )0.6(Im)9.9(p)32(a)-16.9(c)-16(t )0.5(of )]TJ 0.066 Tw -22.144 -1.25 Td [(t)-13(he me)-12(t)-13(hod of inter)-14.9(nal opening cl)30(osur)-24(e of anal f)-28(istul)-16(a on outcomes )]TJ 0.007 Tc 0.35 Tw T* [(af)-28.3(ter l)-16.3(aser f)-28.2(istul)-16.3(a coa)-17.2(gul)-16.2(a)14.8(t)-32.2(ion. P)34.8(r)-24.2(el)-31.2(iminar)-24.1(y r)-24.2(esul)55.8(ts of r)-33.2(and)-16.3(om)]TJ 0 Tc 0 Tw (-)Tj 0.252 Tw T* [(ized cl)-31(inical tr)-37(ial. )]TJ /T1_1 1 Tf 0 Tw [(K)17.9(olop)46.1(roktologia)]TJ /T1_0 1 Tf 0.252 Tw (. 2022;21\(3\):33\22642. \(in Russ.\). )Tj 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.33878/2073-7556-2022-21-3-33-42)Tj 0 0 0 1 k /GS1 gs 0.106 Tw -1.847 -1.25 Td (5.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(A)15(degbol)-16(a)]TJ /Span<>> BDC ( )Tj EMC 4.082 0 Td [(SO, )0.5(Sahnan)]TJ /Span<>> BDC ( )Tj EMC 4.827 0 Td [(K, )0.6(T)44.9(ozer)]TJ /Span<>> BDC ( )Tj EMC 3.497 0 Td [(P, )0.5(e)-11.9(t)]TJ /Span<>> BDC ( )Tj EMC 2.204 0 Td [(al. )0.6(Emer)-32(ging )0.5(Da)15.1(t)15(a )0.5(on )0.6(F)-19.1(istul)-15.9(a )]TJ 0.073 Tw -15.906 -1.25 Td [(L)-32(aser Cl)30(osur)-23.9(e \(F)-19(iL)-32(aC\) for t)-13(he T)50(r)-24(ea)15(tment of P)30(er)-36.9(ianal F)-19(istul)-16(as; P)40(a)15(t)-31.9(ient )]TJ 0.023 Tw T* [(Selec)-16(t)-32(ion and Outcomes. )]TJ /T1_1 1 Tf (Clin Exp Gastroenterol)Tj /T1_0 1 Tf (. 2021;14:467\226475.)Tj 0.124 Tw T* (6.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (de Bonnechose)Tj /Span<>> BDC ( )Tj EMC [(G, L)35(efevr)-23.9(e)]TJ /Span<>> BDC ( )Tj EMC [(JH, A)9.9(uber)-21.9(t)]TJ /Span<>> BDC ( )Tj EMC [(M, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. L)-31.9(aser abl)-16(a)15(t)-32(ion of )]TJ 0.155 Tw -1.296 -1.25 Td [(f)-28(istul)-15.9(a tr)-32.9(a)-17(c)-16(t )0.5(\(L)-35(AFT\) )0.5(and )0.5(com)10(ple)-18(x )0.5(f)-28(istul)-16(a-in-ano: )0.5(\231t)-13(he )0.5(ideal )0.5(indica)]TJ 0 Tw (-)Tj 0.023 Tw T* [(t)-32(ion\232 is becoming clear)-23.9(er\246 )]TJ /T1_1 1 Tf [(T)54(ech Colop)46(roctol)]TJ /T1_0 1 Tf (. 2020;24\(7\):695\226701.)Tj 0.126 Tw T* (7.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (Isik)Tj /Span<>> BDC ( )Tj EMC [(O, Gul)16(cu)]TJ /Span<>> BDC ( )Tj EMC [(B, Oztur)-23.9(k)]TJ /Span<>> BDC ( )Tj EMC [(E. L)35(ong-ter)-16(m outcomes of l)-16(aser abl)-16(a)15(t)-32(ion )]TJ 0.025 Tw -1.296 -1.25 Td [(of f)-28(istul)-16(a tr)-32.9(a)-17.1(c)-15.9(t for f)-28(istul)-16(a-in-ano: a consider)-33(able opt)-32(ion in sphinc)-16(ter )]TJ 0 Tw T* [(p)25(r)-24(eser)-31.9(v)-15(a)15(t)-32(ion. )]TJ /T1_1 1 Tf 0.023 Tw 5.627 0 Td [(Dis Colon R)21(ectum)]TJ /T1_0 1 Tf (. 2020;6:831\226836.)Tj 0.158 Tw -5.627 -1.25 Td (8.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(L)-32(aur)-23.9(e)-12(t)-30(t)15(a)]TJ /Span<>> BDC ( )Tj EMC [(A, F)20(al)16(co)]TJ /Span<>> BDC ( )Tj EMC [(N, S)15(t)17(o)-16(cco)]TJ /Span<>> BDC ( )Tj EMC [(E, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Anal F)-19(istul)-16(a L)-31.9(aser Cl)30(osur)-24(e: )]TJ 0.011 Tc 0.414 Tw -1.296 -1.25 Td [(t)-13.1(he leng)16.8(t)-13.1(h of f)-28.1(istul)-16.2(a is t)-13.1(he A)-25.1(chilles\245 heel. )]TJ /T1_1 1 Tf [(T)53.8(ech Colop)45.8(roctol.)]TJ /T1_0 1 Tf 0 Tc 0 Tw 27.638 0 Td ( )Tj -27.638 -1.25 Td (2018;22\(12\):933\226939.)Tj -0.032 Tw T* (9.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Khi)-24(t)15(ar)-23.9(y)22(an)]TJ /Span<>> BDC ( )Tj EMC [(A.G., K)25(ov)-15(alev)]TJ /Span<>> BDC ( )Tj EMC [(S.A., Kisl)30.1(ov)]TJ /Span<>> BDC ( )Tj EMC [(V.A., e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. R)13(esul)56.1(ts of tr)-23.9(ea)15(tment )]TJ 0.187 Tw -1.296 -1.25 Td [(of tr)-33(anssphinc)-15.9(ter and e)-18(xtr)-32.9(asphinc)-16(ter f)-28(istul)-15.9(as of t)-13(he r)-24(ec)-16(tum using )]TJ 0.027 Tw T* [(modif)-28(ied FIL)-35(A)16(C technol)30(o)-16(g)16(y. )]TJ /T1_1 1 Tf [(Bulletin of Emerg)12(ency and R)21(econstructiv)13.1(e )]TJ 0 Tw T* [(Surg)12(er)-43(y.)]TJ /T1_0 1 Tf 0.023 Tw ( 2016;1\(3\):447\226457. \(in Russ.\).)Tj 0.016 Tw 29.055 33.75 Td (10.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Ma)15(t)-32(iny)22(an)]TJ /Span<>> BDC ( )Tj EMC 3.95 0 Td [(A.V. )0.5(T)50(r)-24(ea)15(tment )0.5(of )0.5(tr)-32.9(ans- )0.5(and e)-17.9(xtr)-33(asphinc)-16(ter )0.6(f)-28(istul)-16(as )0.5(of )]TJ 0.101 Tw -5.746 -1.25 Td [(t)-13(he r)-24(ec)-16(tum b)12(y l)-16(aser t)-13(her)-15.9(mal obl)-31(i)-24(ter)-33(a)15(t)-32(ion of t)-13(he f)-28(istul)-15.9(a cour)-9.9(se. Dis. )]TJ 0.104 Tw T* [(candid)42(a)15(te of Medical S)-24(c)-24(iences: 14.10.21. M)-23.9(osco)-14(w, 2021. 122 p. \(in )]TJ 0 Tw T* (Russ.\).)Tj 0.142 Tw T* (11.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Oztur)-23.9(k)]TJ /Span<>> BDC ( )Tj EMC [(E, )0.5(Gul)16.1(cu)]TJ /Span<>> BDC ( )Tj EMC [(B. )0.5(L)-32(aser )0.6(abl)-16(a)15(t)-32(ion )0.5(of )0.5(F)-19(istul)-16(a )0.5(T)50(r)-33(a)-17(c)-16(t: )0.5(A )0.5(sphinc)-16(ter )]TJ 0.238 Tw -1.796 -1.25 Td [(p)25(r)-24(eser)-31.9(v)-16(ing me)-12(t)-13(hod for )0.5(tr)-24(ea)15(t)-32(ing F)-19(istul)-15.9(a-in-Ano. )]TJ /T1_1 1 Tf [(Dis )0.5(Colon R)21(ectum.)]TJ /T1_0 1 Tf 0 Tw ( )Tj 0.023 Tw T* [(2014;57:360\226364. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1097/DCR.0000000000000067)Tj 0 0 0 1 k /GS1 gs 0.156 Tw T* (12.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Gor)Tj /Span<>> BDC ( )Tj EMC [(I.V. Combined minimall)35.1(y inv)-15(asi)-16(ve me)-12(t)-13(hod of tr)-23.9(ea)15(tment of )]TJ 0.056 Tw -1.796 -1.25 Td [(r)-24(ec)-15.9(t)15(al f)-28(istul)-15.9(a. Disser)-22(t)15(a)15(t)-32(ion of t)-13(he Candid)42(a)15(te of Medical S)-24(c)-24(iences; S)15(t. )]TJ 0.023 Tw T* [(P)30(e)-12(ter)-9.9(sbur)-32(g, 2022. 120 p. \(in Russ.\).)]TJ 0.131 Tw T* (13.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(K)25(ost)15(ar)-24(ev)]TJ /Span<>> BDC ( )Tj EMC (I.V., Kiselev)Tj /Span<>> BDC ( )Tj EMC [(D.O., Bl)-16(a)-17(god)42(ar)-15(ny)]TJ /Span<>> BDC ( )Tj EMC [(L.A., e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Com)10(p)32(ar)-33(a)15(t)-32(i)-16(ve )]TJ 0.233 Tw -1.796 -1.25 Td [(anal)35(y)-13(sis of t)-13(he r)-24(esul)56.1(ts of tr)-24(ea)15(tment of tr)-33(ans- and e)-18(xtr)-32.9(asphinc)-16(ter )]TJ 0.063 Tw T* [(f)-28(istul)-15.9(as )0.5(of )0.5(t)-12.9(he )0.5(r)-24(ec)-16(tum )0.6(b)12(y )0.5(t)-13(he )0.6(me)-12(t)-13(hod )0.5(of )0.6(t)-13(her)-16(mal )0.6(obl)-31(i)-24(ter)-33(a)15(t)-31.9(ion )0.5(of )0.5(t)-13(he )]TJ 0.008 Tw T* [(f)-28(istul)-15.9(a p)32(assa)-17(ge using a diode l)-16(aser or monopol)-16(ar elec)-15.9(tr)-32(o)-16(coa)-17(gul)-16(a)15(t)-32(ion. )]TJ /T1_1 1 Tf 0.016 Tw T* [(V)33(estnik khir)-43(yrgii im.I.I.)]TJ /Span<>> BDC ( )Tj EMC [(Grek)13(ov)16(a.)]TJ /T1_0 1 Tf [( 2020;4:36\22643. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.24884/0042-)Tj T* (4625-2020-179-4-36-43)Tj 0 0 0 1 k /GS1 gs 0.256 Tw T* (14.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Giamund)-15.9(o)]TJ /Span<>> BDC ( )Tj EMC [(P, Eser)-32(c)-24(izio)]TJ /Span<>> BDC ( )Tj EMC [(L, Ger)-32.9(a)-17(c)-24(i)]TJ /Span<>> BDC ( )Tj EMC [(M, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. F)-19(istul)-15.9(a-tr)-33(a)-17(c)-16(t L)-32(aser )]TJ 0.134 Tw -1.796 -1.25 Td [(Cl)30(osur)-23.9(e \(F)-19(iL)-32(aCTM\): l)30.1(ong-ter)-16(m r)-24(esul)56(ts and new oper)-33(a)15(t)-31.9(i)-16(ve str)-32.9(a)15(tegies. )]TJ /T1_1 1 Tf 0.032 Tw T* [(T)54(ech Colop)46(roctol)]TJ /T1_0 1 Tf [(. 2015;19:449\226453. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1007/s10151-015-1282-)Tj T* (9)Tj 0 0 0 1 k /GS1 gs 0.012 Tw T* (15.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(V)25(asil)-31(iev)]TJ /Span<>> BDC ( )Tj EMC [(S.V., Ned)-16(ozomov)-15(anny)]TJ /Span<>> BDC ( )Tj EMC [(A.I., P)10(opov)]TJ /Span<>> BDC ( )Tj EMC [(D.E., e)-11.9(t)]TJ /Span<>> BDC ( )Tj EMC [(al. L)-32(aser coa)-17(g)]TJ 0 Tw (-)Tj 0.086 Tw -1.796 -1.25 Td [(ul)-16(a)15(t)-31.9(ion in combina)15(t)-32(ion wi)-23.9(t)-13(h LIFT for tr)-32.9(anssphinc)-16(ter)-37(ic anal f)-28(istul)-15.9(as. )]TJ /T1_1 1 Tf 0 Tw T* [(K)18(olop)46(roktologia)]TJ /T1_0 1 Tf 0.065 Tw [(. 2021; 20;2:35\22641. \(in Russ.\). d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.33878/2073-)Tj T* (7556-2021-20-2-35-41)Tj 0 0 0 1 k /GS1 gs 0.015 Tw T* (16.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(S)15(tell)-31(ingwer)-23.9(f)]TJ /Span<>> BDC ( )Tj EMC [(ME, v)-15(an P)35(r)-33(aa)-17(g)]TJ /Span<>> BDC ( )Tj EMC [(EM, T)45(ozer)]TJ /Span<>> BDC ( )Tj EMC [(P)35(J, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Sy)-12.9(stema)15(t)-32(ic r)-24(ev)-15.9(iew )]TJ 0.148 Tw -1.796 -1.25 Td [(and me)-12(t)15.1(a-anal)35(y)-13(sis of end)-16(or)-24(ec)-16(t)15.1(al ad)-17(v)-15(ancement fl)-16(ap and l)-31(iga)15(t)-32(ion of )]TJ 0.232 Tw T* [(t)-13(he inter)-10(sphinc)-16(ter)-36.9(ic f)-28(istul)-16(a tr)-32.9(a)-17(c)-16(t for cr)-24(ypt)17(o)-16(gl)-16(andul)-16(ar and Cr)-31.9(ohn\245s )]TJ 0.023 Tw T* [(high per)-37(ianal f)-28(istul)-15.9(as. )]TJ /T1_1 1 Tf (BJS Open)Tj /T1_0 1 Tf (. 2019;3:231\226241.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0 Tw 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\033\030\031\030\213\b)-20.9(\035\231\213\233\t \021\032)50(\b)42(\032\231\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj -51.938 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 23, \023\0221)69(, 202)69(4)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 23, \023\0221)69(, 202)69(4)]TJ /T1_3 1 Tf 25 0 0 25 28.165 56.0378 Tm (70)Tj ET endstream endobj 1878 0 obj <>/Border[0 0 0]/H/N/Rect[98.0624 718.512 206.742 709.216]/Subtype/Link/Type/Annot>> endobj 1879 0 obj <>/Border[0 0 0]/H/N/Rect[85.6442 678.512 179.116 669.216]/Subtype/Link/Type/Annot>> endobj 1880 0 obj <>/Border[0 0 0]/H/N/Rect[85.6442 628.512 212.452 619.216]/Subtype/Link/Type/Annot>> endobj 1881 0 obj <>/Border[0 0 0]/H/N/Rect[379.807 678.512 488.487 669.216]/Subtype/Link/Type/Annot>> endobj 1882 0 obj <>/Border[0 0 0]/H/N/Rect[471.682 598.512 524.409 589.056]/Subtype/Link/Type/Annot>> endobj 1883 0 obj <>/Border[0 0 0]/H/N/Rect[303.307 588.512 381.387 579.216]/Subtype/Link/Type/Annot>> endobj 1884 0 obj <>/Border[0 0 0]/H/N/Rect[434.938 558.512 524.409 549.056]/Subtype/Link/Type/Annot>> endobj 1885 0 obj <>/Border[0 0 0]/H/N/Rect[303.307 548.512 307.307 539.216]/Subtype/Link/Type/Annot>> endobj 1886 0 obj <>/Border[0 0 0]/H/N/Rect[471.682 518.512 524.409 509.056]/Subtype/Link/Type/Annot>> endobj 1887 0 obj <>/Border[0 0 0]/H/N/Rect[303.307 508.512 377.387 499.216]/Subtype/Link/Type/Annot>> endobj 1897 0 obj <> endobj 1896 0 obj <> endobj 1895 0 obj <> endobj 1894 0 obj <> endobj 1893 0 obj <> endobj 1892 0 obj <> endobj 1891 0 obj <> endobj 1890 0 obj <> endobj 1889 0 obj <> endobj 1888 0 obj <> endobj 1874 0 obj [1898 0 R 1899 0 R 1900 0 R 1901 0 R 1902 0 R 1903 0 R 1904 0 R 1905 0 R 1906 0 R 1907 0 R 1908 0 R 1909 0 R] endobj 1875 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\034\205\026\220\007\016\026\001\220\203 \025\221\020\026 \221\002\220\024\ \016\001\016\001\220\205 \024\016\026)11.1(\025\201\013 \007\013\222\016\002\001\025\203 \n)10(\025\013\202)-20(\215\007\205\227\220\220 )]TJ 0 -1 TD [(\221\002\220\022\007\016\017\016\001\220\220 \026\002\013\001\006- \220\022\ \232\n\006)-10(\026\002\013\006\225\220\001\n)-9.9(\026)11(\016\002\001\020\207 \006\r\220\224\016\203 \221\002\205\024\025\203 \n\220\ \n\220)]TJ 37.587 1 Td [(Fiv)12(e)-52(-y)10(ear e)21(xperience of laser coagulation in th)11(e tr)31(eatment )]TJ 6.214 -1 Td [(of tr)21.1(ans- and supr)21.1(asphincteric anal f)-20.9(istulas)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0.023 Tw 10 0 0 10 42.5197 724.8299 Tm (\255\026\036\031\036\025\034\224 \017\225 \032\026\020\017\022\032\221\(\ ORCID\))Tj /T1_2 1 Tf 0.295 Tw 0 -1.218 TD [(\025\024\f\021\026\030\036\r )0.5(\222\r\026\027 )0.6(\200\026\f\017\035\034\036\r\017\004)]TJ /Span<>> BDC ( )Tj EMC 12.246 0 Td [(\227 )0.5(\007.\n.\027., )0.5(\026\r\036\007\031\033\013\017\005 )]TJ 0.1 Tw -12.246 -1.218 Td (\024\021\007\036\035\036\027\017\036\n \n\026\035\024\017\027\r\026\017\ \r\027\024\005 \023\030\024\022\021\024\035\024\020\017\017 \017)Tj /Span<>> BDC ( )Tj EMC (\021\026\024\r\024\005 )Tj 0.103 Tw T* (\b\017\030\031\030\020\017\017 \205\206\207\211 \253\203\204\222\037 \022\ \024\035\024\023\030\024\022\021\024\035\024\020\017\017 \017\n\036\027\017\ \202.\203. )Tj 0.255 Tw T* (\217\t\032\017\b\273 \204\017\027\007\030\026\r\026 \217\024\f\f\017\017\ , \007\024\006\036\027\021 \022\026\235\036\007\030\t \022\024\035\024)Tj 0 Tw (-)Tj 0.218 Tw T* (\023\030\024\022\021\024\035\024\020\017\017 \205\206\207\210\211 \212\215\ \210 \253\217\024\f\f\017\005\f\022\026\016 \n\036\007\017\006\017\027\f\ \022\026\016 )Tj 0.011 Tw 0 -1.218 TD (\026\022\026\007\036\n\017\016 \027\036\023\030\036\030\t\r\027\024\020\024\ \023\030\024\235\036\f\f\017\024\027\026\035\034\027\024\020\024 \024\002\ \030\026\024)Tj 0 Tw (-)Tj 0 -1.218 TD (\r\026\027\017\016\273; ORCID 0000-0002-1778-0571)Tj 0.314 Tw T* (\003\026\b\026\030\016\027 \202\035\036\022\f\026\027\007\030 \200\017\035\ \036\027\024\r\017\004)Tj /Span<>> BDC ( )Tj EMC (\227 \026\f\023\017\030\026\027\021, \r\030\026\004-)Tj 0.294 Tw T* (\022\024\035\024\023\030\024\022\021\024\035\024\020 \024\021\007\036\035\ \036\027\017\016 \n\026\035\024\017\027\r\026\017\r\027\024\005 \023\030\ \024\022\021\024)Tj 0 Tw (-)Tj 0.082 Tw T* (\035\024\020\017\017 \017)Tj /Span<>> BDC ( )Tj EMC (\021\026\024\r\024\005 \b\017\030\031\030\020\017\017 \205\206\207\211 \ \253\203\204\222\037 \022\024\035\024\023\030\024\022\021\024)Tj 0 Tw (-)Tj 0.088 Tw T* (\035\024\020\017\017 \017\n\036\027\017 \202.\203. \217\t\032\017\b\273 \ \204\017\027\007\030\026\r\026 \217\024\f\f\017\017; ORCID )Tj 0 Tw 0 -1.218 TD (0000-0003-1701-142X)Tj 0.422 Tw 0 -1.218 TD (\207\035\026\020\024\007\026\030\027\t\005 \214\036\024\027\017\007 \202\ \035\036\022\f\036\036\r\017\004)Tj /Span<>> BDC ( )Tj EMC (\227 \007.\n.\027., \023\030\024)Tj 0 Tw (-)Tj 0.728 Tw 0 -1.218 TD (\235\036\f\f\024\030 \022\026\235\036\007\030\t \022\024\035\024\023\030\ \024\022\021\024\035\024\020\017\017 \205\206\207\210\211 \212\215\210 )Tj 0.309 Tw T* [(\253\217\024\f\f\017\005\f\022\026\016 )0.6(\n\036\007\017\006\017\027\f\022\026\016 )0.6(\026\022\026\007\036\n\017\016 )0.5(\027\036\023\030\036\030\t\r\027\024\020\024 )]TJ 0 Tw T* (\023\030\024\235\036\f\f\017\024\027\026\035\034\027\024\020\024 \024\002\ \030\026\024\r\026\027\017\016\273)Tj 0.254 Tw T* (\230\017\021\024\r \202\035\036\022\f\026\027\007\030 \236\030\034\036\r\ \017\004)Tj /Span<>> BDC ( )Tj EMC (\227 \007.\n.\027., \030\031\022\024\r\024\007\017\021\036\035\034 )Tj 0.121 Tw T* (\024\021\007\036\035\026 \024\002\013\036\005 \017)Tj /Span<>> BDC ( )Tj EMC (\030\036\022\024\027\f\021\030\031\022\021\017\r\027\024\005 \022\024\035\ \024\023\030\024\022\021\024\035\024\020\017\017 )Tj 0.221 Tw T* (\205\206\207\211 \253\203\204\222\037 \022\024\035\024\023\030\024\022\021\ \024\035\024\020\017\017 \017\n\036\027\017 \202.\203. \217\t\032\017\b\273\ )Tj 0 Tw T* (\204\017\027\007\030\026\r\026 \217\024\f\f\017\017; ORCID 0000-0002-16\ 36-8075)Tj 0.149 Tw 23.244 24.356 Td [(\204\031\007\030\024\r \202\027\007\030\036\005 )0.5(\202\027\026\021\024\035\034\036\r\017\004)]TJ /Span<>> BDC ( )Tj EMC 12.527 0 Td [(\227 \022.\n.\027., )0.5(\027\026\031\004\027\t\005 )0.5(\f\024)]TJ 0 Tw (-)Tj 0.062 Tw -12.527 -1.218 Td [(\021\030\031\007\027\017\022 )0.6(\024\021\007\036\035\036\027\017\016 )0.5(\024\002\013\036\005 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 11.961 0 Td [(\030\036\022\024\027\f\021\030\031\022\021\017\r\027\024\005 )0.6(\022\024\035\024)]TJ 0 Tw (-)Tj 0.274 Tw -11.961 -1.218 Td (\023\030\024\022\021\024\035\024\020\017\017 \205\206\207\211 \253\203\204\ \222\037 \022\024\035\024\023\030\024\022\021\024\035\024\020\017\017 \017\ \n\036\027\017 )Tj 0.043 Tw T* (\202.\203. \217\t\032\017\b\273 \204\017\027\007\030\026\r\026 \217\024\ \f\f\017\017, \007\024\006\036\027\021 \022\026\235\036\007\030\t \022\024\ )Tj 0 Tw (-)Tj -0.026 Tw T* (\035\024\023\030\024\022\021\024\035\024\020\017\017 \205\206\207\210\211\ \212\215\210 \253\217\024\f\f\017\005\f\022\026\016 \n\036\007\017\006\017\ \027\f\022\026\016 )Tj 0.133 Tw T* (\026\022\026\007\036\n\017\016 \027\036\023\030\036\030\t\r\027\024\020\024\ \023\030\024\235\036\f\f\017\024\027\026\035\034\027\024\020\024\024\002\ \030\026\024)Tj 0 Tw (-)Tj 0 -1.218 TD (\r\026\027\017\016\273; ORCID 0000-0002-1207-5988)Tj 0.217 Tw 0 -1.218 TD (\025\017\f\036\035\036\r \212\n\017\021\030\017\005 \210\035\036\020\024\ \r\017\004)Tj /Span<>> BDC ( )Tj EMC (\227 \022.\n.\027., \r\030\026\004 \031\035\034\021\030\026)Tj 0 Tw (-)Tj 0.248 Tw T* (\r\031\022\024\r\024\005 \007\017\026\020\027\024\f\021\017\022\017 \205\ \206\207\211 \253\203\204\222\037 \022\024\035\024\023\030\024\022\021\024\ \035\024)Tj 0 Tw (-)Tj 0.251 Tw T* (\020\017\017 \017\n\036\027\017 \202.\203. \217\t\032\017\b\273 \204\017\ \027\007\030\026\r\026 \217\024\f\f\017\017; ORCID )Tj 0 Tw T* (0000-0001-8332-7540)Tj /T1_1 1 Tf 0.023 Tw 0 -2.436 TD (INFORMATION ABOUT THE AUTHORS \(ORCID\))Tj /T1_2 1 Tf 0 Tw 0 -1.218 TD [(Iv)-15(an V. K)25.1(ost)15(ar)-24(ev)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0002-1778-0571)Tj 0 -1.218 TD [(Ale)-18(x)-10.9(ander V. Z)10(akhar)-23.9(y)22(an)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0003-1701-142X)Tj T* [(L)35(eonid A. Bl)-15.9(a)-17(god)42(ar)-15(ny)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0002-1081-1793)Tj T* [(Ale)-18(x)-10.9(ander Y)35(u. T)35(i)-24(t)17.1(ov)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0002-1636-8075)Tj T* [(Andr)-24(e)-10.9(y A. Mudr)-32(ov)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0002-1207-5988)Tj T* [(Dmi)-24(tr)-23.9(y O. Kiselev)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0001-8332-7540)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 42.5896 444.7359 Tm [(\r\031\024\034\033)48(\026)45(\024)-10(\223\033)48(\026)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf 0.367 Tw 8 0 0 8 42.5197 431.9012 Tm (1.)Tj /Span<>> BDC ( )Tj EMC 1.325 0 Td (\204\026\021\017\027\016\027)Tj /Span<>> BDC ( )Tj EMC (\202.\200., \025\024\f\021\026\030\036\r)Tj /Span<>> BDC ( )Tj EMC (\222.\200., \207\035\026\020\024\007\026\030\027\t\005)Tj /Span<>> BDC ( )Tj EMC (\214.\202., \017)Tj /Span<>> BDC ( )Tj EMC [(\f\024\026\r\021.)10( )]TJ 0 Tc 0.007 Tw -1.325 -1.25 Td (\214\036\004\036\027\017\036 \f\r\017\013\036\005 \023\030\016\n\024\005\ \022\017\001\022\017 \n\036\021\024\007\024\n \035\026\036\030\027\024\ \005 \021\036\030\n\024\024\002\035\017\021\036\030\026)Tj 0 Tw (-)Tj 0.071 Tw 0 -1.25 TD (\006\017\017 \f\r\017\013\036\r\024\020\024 \b\024\007\026 \(\f\017\f\021\ \036\n\026\021\017\004\036\f\022\017\005 \024\002\024\030\). )Tj /T1_4 1 Tf 0 Tw (\222\n\023\n\033\032\n\013\024\n\023\n\202\025\002. )Tj /T1_2 1 Tf 0.023 Tw T* [(2019;18\(3\):7\22619. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.33878/2073-7556-2019-18-3-7-19)Tj 0 0 0 1 k /GS1 gs 0.025 Tw T* (2.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Must)15(af)16(a)]TJ /Span<>> BDC ( )Tj EMC 3.393 0 Td [(CT, )0.5(Cihan)]TJ /Span<>> BDC ( )Tj EMC 3.875 0 Td [(A, )0.5(e)-12(t)]TJ /Span<>> BDC ( )Tj EMC 2.085 0 Td [(al. )0.5(Cl)30(osing )0.6(P)30(er)-37(ianal )0.6(F)-19(istul)-16(as )0.6(Using )0.5(a )0.5(L)-31.9(aser: )]TJ 0.044 Tw -10.649 -1.25 Td [(L)35(ong-T)40(er)-16(m R)13(esul)56(ts in 103 P)40(a)15(t)-32(ients. )]TJ /T1_4 1 Tf [(Dis Colon R)21(ectum. )]TJ /T1_2 1 Tf 0 Tw (2018;61:5:00\226)Tj 0.023 Tw T* [(00. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1097/DCR.0000000000001038)Tj 0 0 0 1 k /GS1 gs 0.134 Tw T* (3.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(W)-16(ilhelm)]TJ /Span<>> BDC ( )Tj EMC [(A, F)-19(iebig)]TJ /Span<>> BDC ( )Tj EMC [(A, Kr)-32.9(a)10(wezak)]TJ /Span<>> BDC ( )Tj EMC [(M. F)-19(i)-16(ve year)-10(s of e)-18(xper)-36.9(ience wi)-24(t)-13(h )]TJ 0.272 Tw -1.296 -1.25 Td [(t)-13(he F)-19(iL)-32(aC l)-16(aser for f)-28(istul)-16(a-in-ano mana)-17(gement l)30(ong-ter)-16(m foll)30(o)-14(w-)]TJ 0.244 Tw T* [(up )0.6(fr)-32(om )0.6(a )0.5(single )0.6(inst)-32(i)-23.9(tut)-32(ion. )]TJ /T1_4 1 Tf 12.883 0 Td [(T)54(ech )0.6(Colop)46(roctol)]TJ /T1_2 1 Tf [(. )0.5(2017;21:269\226276. )]TJ 0 Tw -12.883 -1.25 Td [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1007/s10151-017-1599-7)Tj 0 0 0 1 k /GS1 gs -0.05 Tw -1.847 -1.25 Td (4.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (\003\026\b\026\030\016\027)Tj /Span<>> BDC ( )Tj EMC (\202.\200., \025\024\f\021\026\030\036\r)Tj /Span<>> BDC ( )Tj EMC (\222.\200., \207\035\026\020\024\007\026\030\027\t\005)Tj /Span<>> BDC ( )Tj EMC (\214.\202., \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. \200\035\017\016\027\017\036 )Tj 0.075 Tw -1.296 -1.25 Td [(\f\023\024\f\024\002\026 )0.5(\026\022\030\t\021\017\016 )0.5(\r\027\031\021\030\036\027\027\036\020\024 )0.6(\f\r\017\013\036\r\024\020\024 )0.5(\024\021\r\036\030\f\021\017\016 )0.5(\027\026)]TJ /Span<>> BDC ( )Tj EMC 23.687 0 Td (\030\036\031\035\034\021\026)Tj 0 Tw (-)Tj 0.068 Tw -23.687 -1.25 Td (\021\t \035\036\004\036\027\017\016 \f\r\017\013\036\005 \023\030\016\n\024\ \005 \022\017\001\022\017 \n\036\021\024\007\024\n \035\026\036\030\027\ \024\005 \022\024\026\020\031\035\016\006\017\017. )Tj 0.022 Tw T* (\215\030\036\007\r\026\030\017\021\036\035\034\027\t\036 \030\036\031\035\ \034\021\026\021\t \030\026\027\007\024\n\017\017\030\024\r\026\027\027\ \024\020\024 \017\f\f\035\036\007\024\r\026\027\017\016. )Tj /T1_4 1 Tf 0 Tw T* (\222\n\023\n\033\032\n\013\024\n\023\n\202\025\002.)Tj /T1_2 1 Tf 0.321 Tw [( 2022;21\(3\):33\22642. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.33878/2073-7556-)Tj T* (2022-21-3-33-42)Tj 0 0 0 1 k /GS1 gs 0.106 Tw T* (5.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(A)15(degbol)-16(a)]TJ /Span<>> BDC ( )Tj EMC 4.082 0 Td [(SO, )0.5(Sahnan)]TJ /Span<>> BDC ( )Tj EMC 4.827 0 Td [(K, )0.6(T)44.9(ozer)]TJ /Span<>> BDC ( )Tj EMC 3.497 0 Td [(P, )0.5(e)-11.9(t)]TJ /Span<>> BDC ( )Tj EMC 2.204 0 Td [(al. )0.6(Emer)-32(ging )0.5(Da)15.1(t)15(a )0.5(on )0.6(F)-19.1(istul)-15.9(a )]TJ 0.073 Tw -15.906 -1.25 Td [(L)-32(aser Cl)30(osur)-23.9(e \(F)-19(iL)-32(aC\) for t)-13(he T)50(r)-24(ea)15(tment of P)30(er)-36.9(ianal F)-19(istul)-16(as; P)40(a)15(t)-31.9(ient )]TJ 0.023 Tw T* [(Selec)-16(t)-32(ion and Outcomes. )]TJ /T1_4 1 Tf (Clin Exp Gastroenterol)Tj /T1_2 1 Tf (. 2021;14:467\226475.)Tj 0.124 Tw T* (6.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (de Bonnechose)Tj /Span<>> BDC ( )Tj EMC [(G, L)35(efevr)-23.9(e)]TJ /Span<>> BDC ( )Tj EMC [(JH, A)9.9(uber)-21.9(t)]TJ /Span<>> BDC ( )Tj EMC [(M, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. L)-31.9(aser abl)-16(a)15(t)-32(ion of )]TJ 0.155 Tw -1.296 -1.25 Td [(f)-28(istul)-15.9(a tr)-32.9(a)-17(c)-16(t )0.5(\(L)-35(AFT\) )0.5(and )0.5(com)10(ple)-18(x )0.5(f)-28(istul)-16(a-in-ano: )0.5(\231t)-13(he )0.5(ideal )0.5(indica)]TJ 0 Tw (-)Tj 0.023 Tw T* [(t)-32(ion\232 is becoming clear)-23.9(er\246 )]TJ /T1_4 1 Tf [(T)54(ech Colop)46(roctol)]TJ /T1_2 1 Tf (. 2020;24\(7\):695\226701.)Tj 0.126 Tw T* (7.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (Isik)Tj /Span<>> BDC ( )Tj EMC [(O, Gul)16(cu)]TJ /Span<>> BDC ( )Tj EMC [(B, Oztur)-23.9(k)]TJ /Span<>> BDC ( )Tj EMC [(E. L)35(ong-ter)-16(m outcomes of l)-16(aser abl)-16(a)15(t)-32(ion )]TJ 0.025 Tw -1.296 -1.25 Td [(of f)-28(istul)-16(a tr)-32.9(a)-17.1(c)-15.9(t for f)-28(istul)-16(a-in-ano: a consider)-33(able opt)-32(ion in sphinc)-16(ter )]TJ 0 Tw T* [(p)25(r)-24(eser)-31.9(v)-15(a)15(t)-32(ion. )]TJ /T1_4 1 Tf 0.023 Tw 5.627 0 Td [(Dis Colon R)21(ectum)]TJ /T1_2 1 Tf (. 2020;6:831\226836.)Tj 0.158 Tw -5.627 -1.25 Td (8.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(L)-32(aur)-23.9(e)-12(t)-30(t)15(a)]TJ /Span<>> BDC ( )Tj EMC [(A, F)20(al)16(co)]TJ /Span<>> BDC ( )Tj EMC [(N, S)15(t)17(o)-16(cco)]TJ /Span<>> BDC ( )Tj EMC [(E, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Anal F)-19(istul)-16(a L)-31.9(aser Cl)30(osur)-24(e: )]TJ 0.011 Tc 0.414 Tw -1.296 -1.25 Td [(t)-13.1(he leng)16.8(t)-13.1(h of f)-28.1(istul)-16.2(a is t)-13.1(he A)-25.1(chilles\245 heel. )]TJ /T1_4 1 Tf [(T)53.8(ech Colop)45.8(roctol.)]TJ /T1_2 1 Tf 0 Tc 0 Tw 27.638 0 Td ( )Tj -27.638 -1.25 Td (2018;22\(12\):933\226939.)Tj 0.163 Tw T* (9.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (\216\017\021\026\030\034\016\027)Tj /Span<>> BDC ( )Tj EMC (\202.\206., \025\024\r\026\035\036\r)Tj /Span<>> BDC ( )Tj EMC (\221.\202., \025\017\f\035\024\r)Tj /Span<>> BDC ( )Tj EMC (\200.\202., \f)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. \217\036\031\035\034\021\026\021\t )Tj 0.33 Tw -1.296 -1.25 Td (\035\036\004\036\027\017\016 \021\030\026\027\f\f\235\017\027\022\021\036\ \030\027\t\b \017)Tj /Span<>> BDC ( )Tj EMC (\220\022\f\021\030\026\f\235\017\027\022\021\036\030\027\t\b \f\r\017\013\ \036\005 \023\030\016)Tj 0 Tw (-)Tj 0.262 Tw 29.055 37.5 Td (\n\024\005 \022\017\001\022\017 \f)Tj /Span<>> BDC ( )Tj EMC [(\017\f\023\024\035\034\024\r\026\027\017\036\n \n\024\007\017\235\017\006\ \017\030\024\r\026\027\027\024\005 FIL)-35(A)16(C \021\036\b\027\024)]TJ 0 Tw (-)Tj 0.006 Tc -0.006 Tw T* (\035\024\020\017\017. )Tj /T1_4 1 Tf 0.35 Tw 3.301 0 Td [(\216\031\t\024\021\025\013 )0.5(\021\031\n\024\023\n\204\021\n\017 )0.6(\025)]TJ /Span<>> BDC ( )Tj EMC 11.176 0 Td [(\027\n\t\t\024\026\021\n\027\025\024\031\023\022\021\n\017 )0.5(\004\025\032\205\032\202\025\025.)6( )]TJ /T1_2 1 Tf 0 Tc 0 Tw -14.477 -1.25 Td (2016;1\(3\):447\226457.)Tj 0.216 Tw T* (10.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (\204\026\021\017\027\016\027)Tj /Span<>> BDC ( )Tj EMC 3.97 0 Td [(\202.\200. )0.5(\214\036\004\036\027\017\036 )0.6(\021\030\026\027\f- )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC [(\220\022\f\021\030\026\f\235\017\027\022\021\036\030\027\t\b )0.6(\f\r\017\013\036\005 )]TJ 0.248 Tw -5.766 -1.25 Td (\023\030\016\n\024\005 \022\017\001\022\017 \n\036\021\024\007\024\n \035\ \026\036\030\027\024\005 \021\036\030\n\024\024\002\035\017\021\036\030\ \026\006\017\017 \f\r\017\013\036\r\024\020\024 )Tj 0.023 Tw T* (\b\024\007\026. \212\017\f. \022\026\027\007. \n\036\007. \027\026\031\022\ : 14.10.21. \204\024\f\022\r\026, 2021. 122 \f.)Tj 0.142 Tw T* (11.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Oztur)-23.9(k)]TJ /Span<>> BDC ( )Tj EMC [(E, )0.5(Gul)16.1(cu)]TJ /Span<>> BDC ( )Tj EMC [(B. )0.5(L)-32(aser )0.6(abl)-16(a)15(t)-32(ion )0.5(of )0.5(F)-19(istul)-16(a )0.5(T)50(r)-33(a)-17(c)-16(t: )0.5(A )0.5(sphinc)-16(ter )]TJ 0.238 Tw -1.796 -1.25 Td [(p)25(r)-24(eser)-31.9(v)-16(ing me)-12(t)-13(hod for )0.5(tr)-24(ea)15(t)-32(ing F)-19(istul)-15.9(a-in-Ano. )]TJ /T1_4 1 Tf [(Dis )0.5(Colon R)21(ectum.)]TJ /T1_2 1 Tf 0 Tw ( )Tj 0.023 Tw T* [(2014;57:360\226364. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1097/DCR.0000000000000067)Tj 0 0 0 1 k /GS1 gs 0.173 Tw T* (12.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (\206\024\030)Tj /Span<>> BDC ( )Tj EMC (\222.\200. \025\024\n\002\017\027\017\030\024\r\026\027\027\t\005 \n\026\ \035\024\017\027\r\026\017\r\027\t\005 \n\036\021\024\007 \035\036\004\036\ \027\017\016 )Tj 0.254 Tw -1.796 -1.25 Td (\f\r\017\013\036\005 \023\030\016\n\024\005 \022\017\001\022\017. \212\017\ \f. \022\026\027\007. \n\036\007. \027\026\031\022; \221\026\027\022\021\ -\215\036\021\036\030\002\031\030\020, )Tj 0.023 Tw T* (2022. 120 \f.)Tj 0.004 Tc 0.35 Tw T* (13.)Tj /Span<>> BDC ( )Tj EMC 1.814 0 Td (\025\024\f\021\026\030\036\r)Tj /Span<>> BDC ( )Tj EMC (\222.\200., \025\017\f\036\035\036\r)Tj /Span<>> BDC ( )Tj EMC (\212.\210., \207\035\026\020\024\007\026\030\027\t\005)Tj /Span<>> BDC ( )Tj EMC (\214.\202., \017)Tj /Span<>> BDC ( )Tj EMC [(\f\024\026\r\021.)4( )]TJ 0 Tc 0.062 Tw -1.814 -1.25 Td (\221\030\026\r\027\017\021\036\035\034\027\t\005 \026\027\026\035\017 \030\ \036\031\035\034\021\026\021\024\r \035\036\004\036\027\017\016 \021\030\ \026\027\f- \017)Tj /Span<>> BDC ( )Tj EMC (\220\022\f\021\030\026\f\235\017\027)Tj 0 Tw (-)Tj -0.018 Tw T* (\022\021\036\030\027\t\b \f\r\017\013\036\005 \023\030\016\n\024\005 \022\ \017\001\022\017 \n\036\021\024\007\024\n \021\036\030\n\024\024\002\035\ \017\021\036\030\026\006\017\017 \f\r\017\013\036)Tj 0 Tw (-)Tj -0.014 Tw T* (\r\024\020\024 \b\024\007\026 \f)Tj /Span<>> BDC ( )Tj EMC (\023\024\n\024\013\034\033 \007\017\024\007\027\024\020\024 \035\026\036\ \030\026 \017\035\017 \n\024\027\024\023\024\035\016\030\027\024\005 \220\ \035\036\022\021\030\024)Tj 0 Tw (-)Tj T* (\022\024\026\020\031\035\016\006\017\017. )Tj /T1_4 1 Tf 0.212 Tw 5.471 0 Td (\216\031\t\024\021\025\013 \004\025\032\205\032\202\025\025 \025\003. \215\ .\215. \210\032\031\013\n\027\026.)Tj /T1_2 1 Tf ( 2020;4:36\22643. )Tj 0 Tw -5.471 -1.25 Td [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.24884/0042-4625-2020-179-4-36-43)Tj 0 0 0 1 k /GS1 gs 0.256 Tw -1.847 -1.25 Td (14.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Giamund)-15.9(o)]TJ /Span<>> BDC ( )Tj EMC [(P, Eser)-32(c)-24(izio)]TJ /Span<>> BDC ( )Tj EMC [(L, Ger)-32.9(a)-17(c)-24(i)]TJ /Span<>> BDC ( )Tj EMC [(M, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. F)-19(istul)-15.9(a-tr)-33(a)-17(c)-16(t L)-32(aser )]TJ 0.134 Tw -1.796 -1.25 Td [(Cl)30(osur)-23.9(e \(F)-19(iL)-32(aCTM\): l)30.1(ong-ter)-16(m r)-24(esul)56(ts and new oper)-33(a)15(t)-31.9(i)-16(ve str)-32.9(a)15(tegies. )]TJ /T1_4 1 Tf 0.032 Tw T* [(T)54(ech Colop)46(roctol)]TJ /T1_2 1 Tf [(. 2015;19:449\226453. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1007/s10151-015-1282-)Tj T* (9)Tj 0 0 0 1 k /GS1 gs 0.001 Tc 0.349 Tw T* [(1)0.5(5)0.6(.)]TJ /Span<>> BDC 1.297 0 Td ( )Tj EMC 0.5 0 Td [(\200)0.6(\026)0.5(\f)0.6(\017)0.5(\035)0.6(\034)0.5(\036)0.6(\r)]TJ /Span<>> BDC 3.824 0 Td ( )Tj EMC [(\221)0.5(.)0.6(\200)0.5(.)0.6(,)0.5( \203)0.6(\036)0.5(\007)0.6(\024)0.5()0.6(\017)0.5(\n)0.6(\024)0.5(\r)0.6(\026)0.5(\027)0.6(\t)0.5(\005)]TJ /Span<>> BDC 9.635 0 Td ( )Tj EMC [(\202)0.5(.)0.6(\222)0.6(.)0.5(,)0.5( \215)0.6(\024)0.5(\023)0.6(\024)0.5(\r)]TJ /Span<>> BDC 5.703 0 Td ( )Tj EMC [(\212)0.5(.)0.6(\213)0.6(.)0.5(,)0.5( \017)]TJ /Span<>> BDC 3.543 0 Td ( )Tj EMC [(\f)0.5(\024)0.6(\026)0.5(\r)0.6(\021)0.5(.)1( )]TJ 0.009 Tc 0.351 Tw -24.503 -1.25 Td [(\210\023\t\021 \022\024\n\002\017\027\017\030\024\r\026\027\027\024\020\024\ \017\f\023\024\035\034\024\r\026\027\017\016 \035\026\036\030\027\024\ \005 \022\024\026\020\031\035\016\006\017\017)9.1( )]TJ 0.001 Tc 0.349 Tw T* (\r)Tj /Span<>> BDC 0.475 0 Td ( )Tj EMC [(\f)0.5(\024)0.5(\004)0.5(\036)0.5(\021)0.5(\026\027)0.5(\017)0.5(\017)0.5( \f)]TJ /Span<>> BDC 5.872 0 Td ( )Tj EMC [(\n)0.5(\036)0.5(\021)0.5(\024)0.5(\007\017)0.5(\022)0.5(\024)0.5(\005)0.5( L)0.5(I)0.5(F)0.5(T)0.5( \023)0.5(\030)0.5(\017)]TJ /Span<>> BDC ( )Tj EMC [(\035\036)0.5(\004)0.5(\036)0.5(\027)0.5(\017)0.5(\017)0.5( \021)0.5(\030)0.5(\026)0.5(\027)0.5(\f)0.5(\f\235)0.5(\017)0.5(\022)0.5(\021)0.5(\036)0.5(\030)0.5(\027)0.5(\t)0.5(\b)1( )]TJ 0.01 Tc 0.37 Tw -6.347 -1.25 Td [(\f\r\017\013\036\005 )0.5(\023\030\016\n\024\005 )0.5(\022\017\001\022\017. )]TJ /T1_4 1 Tf -0.01 Tw 11.094 0 Td (\222\n\023\n\033\032\n\013\024\n\023\n\202\025\002.)Tj /T1_2 1 Tf 0.37 Tw [( )0.5(2021; )0.5(20;2:35\22641.)10( )]TJ 0 Tc 0 Tw -11.094 -1.25 Td [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.33878/2073-7556-2021-20-2-35-41)Tj 0 0 0 1 k /GS1 gs 0.015 Tw -1.847 -1.25 Td (16.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(S)15(tell)-31(ingwer)-23.9(f)]TJ /Span<>> BDC ( )Tj EMC [(ME, v)-15(an P)35(r)-33(aa)-17(g)]TJ /Span<>> BDC ( )Tj EMC [(EM, T)45(ozer)]TJ /Span<>> BDC ( )Tj EMC [(P)35(J, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Sy)-12.9(stema)15(t)-32(ic r)-24(ev)-15.9(iew )]TJ 0.148 Tw -1.796 -1.25 Td [(and me)-12(t)15.1(a-anal)35(y)-13(sis of end)-16(or)-24(ec)-16(t)15.1(al ad)-17(v)-15(ancement fl)-16(ap and l)-31(iga)15(t)-32(ion of )]TJ 0.232 Tw T* [(t)-13(he inter)-10(sphinc)-16(ter)-36.9(ic f)-28(istul)-16(a tr)-32.9(a)-17(c)-16(t for cr)-24(ypt)17(o)-16(gl)-16(andul)-16(ar and Cr)-31.9(ohn\245s )]TJ 0.023 Tw T* [(high per)-37(ianal f)-28(istul)-15.9(as. )]TJ /T1_4 1 Tf (BJS Open)Tj /T1_2 1 Tf (. 2019;3:231\226241.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 42.5896 103.7519 Tm (REFERENCES)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf 0 Tc 0.096 Tw 8 0 0 8 42.5197 90.9172 Tm (1.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Ma)15(t)-32(iny)22(an)]TJ /Span<>> BDC ( )Tj EMC 4.03 0 Td [(A.V., )0.6(K)25(ost)15(ar)-24(ev)]TJ /Span<>> BDC ( )Tj EMC 5.92 0 Td [(I.V., )0.5(Bl)-15.9(a)-17(god)42(ar)-15(ny)]TJ /Span<>> BDC ( )Tj EMC 6.824 0 Td [(L.A., )0.6(e)-12(t)]TJ /Span<>> BDC ( )Tj EMC 3.263 0 Td [(al. )0.5(F)-19(istul)-15.9(a )0.5(l)-15.9(aser )]TJ 0.008 Tc 0.349 Tw -21.333 -1.25 Td [(abl)-15.7(a)15.3(t)-31.7(ion for anal f)-27.7(istul)-15.7(as \(sy)-12.7(stema)15.3(t)-31.7(ic r)-23.7(ev)-15.7(iew\). )]TJ /T1_4 1 Tf -0.008 Tw [(K)18.3(olop)46.3(roktologia)]TJ /T1_2 1 Tf 0 Tc 0 Tw (. )Tj 0.329 Tw 29.055 1.25 Td [(2019;18\(3\):7\22619. \(in Russ.\). d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.33878/2073-7556-2019-18-)Tj T* (3-7-19)Tj /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\033\030\031\030\213\b)-20.9(\035\231\213\233\t \021\032)50(\b)42(\032\231\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj /T1_5 1 Tf 25 0 0 25 512.8518 56.0378 Tm (69)Tj ET endstream endobj 1898 0 obj <>/Border[0 0 0]/H/N/Rect[116.94 409.197 239.747 399.901]/Subtype/Link/Type/Annot>> endobj 1899 0 obj <>/Border[0 0 0]/H/N/Rect[69.716 379.197 178.396 369.901]/Subtype/Link/Type/Annot>> endobj 1900 0 obj <>/Border[0 0 0]/H/N/Rect[57.2978 339.197 150.769 329.901]/Subtype/Link/Type/Annot>> endobj 1901 0 obj <>/Border[0 0 0]/H/N/Rect[192.078 289.197 263.622 279.741]/Subtype/Link/Type/Annot>> endobj 1902 0 obj <>/Border[0 0 0]/H/N/Rect[42.5197 279.197 97.7834 269.901]/Subtype/Link/Type/Annot>> endobj 1903 0 obj <>/Border[0 0 0]/H/N/Rect[351.461 359.197 460.14 349.901]/Subtype/Link/Type/Annot>> endobj 1904 0 obj <>/Border[0 0 0]/H/N/Rect[289.739 269.197 420.546 259.901]/Subtype/Link/Type/Annot>> endobj 1905 0 obj <>/Border[0 0 0]/H/N/Rect[406.591 239.197 496.063 229.741]/Subtype/Link/Type/Annot>> endobj 1906 0 obj <>/Border[0 0 0]/H/N/Rect[274.961 229.197 278.961 219.901]/Subtype/Link/Type/Annot>> endobj 1907 0 obj <>/Border[0 0 0]/H/N/Rect[289.739 179.197 416.546 169.901]/Subtype/Link/Type/Annot>> endobj 1908 0 obj <>/Border[0 0 0]/H/N/Rect[394.887 98.2133 496.063 88.9172]/Subtype/Link/Type/Annot>> endobj 1909 0 obj <>/Border[0 0 0]/H/N/Rect[274.961 88.2133 296.592 78.9172]/Subtype/Link/Type/Annot>> endobj 1921 0 obj <> endobj 1920 0 obj <> endobj 1919 0 obj <> endobj 1918 0 obj <> endobj 1917 0 obj <> endobj 1916 0 obj <> endobj 1915 0 obj <> endobj 1914 0 obj <> endobj 1913 0 obj <> endobj 1912 0 obj <> endobj 1911 0 obj <> endobj 1910 0 obj <> endobj 1873 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.01 Tc 0.223 Tw 10 0 0 10 70.8661 724.8299 Tm (\023\024\f\035\036 \023\030\017\n\036\027\036\027\017\016 \035\026\036\030\ \027\t\b \021\036\b\027\024\035\024\020\017\005 \f)Tj /Span<>> BDC ( )Tj EMC (\007\026\027\027\t)Tj 0 Tc 0 Tw (-)Tj 0.01 Tc 0.139 Tw 0 -1.218 TD (\n\017 \n\036\021\026\026\027\026\035\017\026 Sameh)Tj /Span<>> BDC ( )Tj EMC (H.E. \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. \(2020\), \r\022\035\033)Tj 0 Tc 0 Tw (-)Tj 0.01 Tc 0.099 Tw T* (\004\017\r\001\036\020\024 \030\036\031\035\034\021\026\021\t 26 \017\f\ \f\035\036\007\024\r\026\027\017\005 \f)Tj /Span<>> BDC ( )Tj EMC [(\f\031\n\n\026\030\027\t\n)10( )]TJ 0.044 Tw T* [(\022\024\035\017\004\036\f\021\r\024\n )0.5(1378 )0.5(\023\026\006\017\036\027\021\024\r, )0.5(\022\024\021\024\030\t\n )0.5(\002\t\035\026 )0.5(\r\t\023\024\035)]TJ 0 Tc 0 Tw (-)Tj 0.01 Tc 0.099 Tw T* [(\027\036\027\026 \017\024\035\017\030\024\r\026\027\027\026\016 \n\036\021\ \024\007\017\022\026 LIFT, \n\024\032\027\024 \031\r\017\007\036\021\034\ )10( )]TJ 0.096 Tw T* [(\024\004\036\027\034 \f\b\024\032\017\036 \023\024\022\026\026\021\036\035\ \017 \026\032\017\r\035\036\027\017\016 \f\r\017\013\036\005. \230\026\022\ ,)10( )]TJ 0.202 Tw 0 -1.218 TD (\r)Tj /Span<>> BDC ( )Tj EMC (\007\026\027\027\024\n \n\036\021\026\026\027\026\035\017\036 \023\030\017\ \r\024\007\017\021\f\016 \f\030\036\007\027\016\016 \004\026\f\021\024)Tj 0 Tc 0 Tw (-)Tj 0.01 Tc 0.173 Tw 0 -1.218 TD (\021\026 \026\032\017\r\035\036\027\017\016 \023\030\017)Tj /Span<>> BDC ( )Tj EMC [(\017\f\023\024\035\034\024\r\026\027\017\017 \017\024\035\017\030\024\r\ \026\027\027\024\005)10( )]TJ 0.062 Tw T* (\n\036\021\024\007\017\022\017 LIFT, \030\026\r\027\026\016 76,5%. \224\021\ \024 \n\024\032\036\021 \f\r\017\007\036\021\036\035\034)Tj 0 Tc 0 Tw (-)Tj 0.01 Tc 0.095 Tw T* (\f\021\r\024\r\026\021\034 \024)Tj /Span<>> BDC ( )Tj EMC (\021\024\n, \004\021\024 \f\026\n\026 \022\024\026\020\031\035\016\006\017\ \016 \f\021\036\027\024\022 \f\r\017\013\036)Tj 0 Tc 0 Tw (-)Tj 0.01 Tc 0.226 Tw T* (\r\024\020\024 \b\024\007\026 \f)Tj /Span<>> BDC ( )Tj EMC [(\023\024\n\024\013\034\033 )0.5(\007\017\024\007\027\024\020\024 \035\026\036\030\026, \r\036\030\024\016\ \021\027\024,)10( )]TJ 0.115 Tw T* (\017\n\036\036\021 \r\021\024\030\024\f\021\036\023\036\027\027\024\036 \ \017\035\017 \r\f\023\024\n\024\020\026\021\036\035\034\027\024\036 \027\ \026\004\036)Tj 0 Tc 0 Tw (-)Tj 0.01 Tc -0.02 Tw 0 -1.218 TD (\027\017\036, \r)Tj /Span<>> BDC ( )Tj EMC (\021\024 \r\030\036\n\016 \022\026\022 \024\f\027\024\r\027\031\033 \030\ \024\035\034 \r)Tj /Span<>> BDC ( )Tj EMC (\007\024\f\021\017\032\036\027\017\017 \023\024)Tj 0 Tc 0 Tw (-)Tj 0.01 Tc 0.079 Tw 0 -1.218 TD [(\035\024\032\017\021\036\035\034\027\024\020\024 \030\036\031\035\034\021\ \026\021\026 \027\036\f\036\021 \027\026\007\036\032\027\024\036 \026\022\ \030\t\021\017\036)10( )]TJ 0.122 Tw 0 -1.218 TD (\r\027\031\021\030\036\027\027\036\020\024 \f\r\017\013\036\r\024\020\024\ \024\021\r\036\030\f\021\017\016 \017)Tj /Span<>> BDC ( )Tj EMC (\017\024\035\016\006\017\016 \f\r\017)Tj 0 Tc 0 Tw (-)Tj 0.01 Tc 0.06 Tw T* [(\013\036\r\024\020\024 \b\024\007\026 \024\021 \023\030\024\f\r\036\021\026\ \023\030\016\n\024\005 )0.5(\022\017\001\022\017. )0.5(\211\022\026\026\027\027\t\036)10( )]TJ 0.03 Tw T* [(\023\030\036\007\023\024\035\024\032\036\027\017\016 \017\n\036\033\021 \ \024\002\255\036\022\021\017\r\027\024\036 \023\024\007\021\r\036\030\032\ \007\036\027\017\036)10( )]TJ 0.163 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\023\024\n\024\013\034\033 \n\024\030\235\024\035\024\020\017\004\036\f\022\ \024\020\024 \017\f\f\035\036\007\024\r\026\027\017\016 \017\f\f\036)Tj 0 Tc 0 Tw (-)Tj 0.01 Tc -0.044 Tw T* [(\004\036\027\027\t\b \023\024\f\035\036 \035\026\036\030\027\024\005 \022\ \024\026\020\031\035\016\006\017\017 \f\r\017\013\036\r\t\b \b\024\007\024\ \r,)10( )]TJ -0.029 Tw T* (\023\030\017)Tj /Span<>> BDC ( )Tj EMC (\022\024\021\024\030\024\n \027\017 \r)Tj /Span<>> BDC ( )Tj EMC [(\024\007\027\024\n \f\035\031\004\026\036 \027\036 \002\t\035\024 \r\t\016\ \r\035\036\027\024 \017\b)10( )]TJ 0 Tw T* (\023\024\035\027\024\005 \024\002\035\017\021\036\030\026\006\017\017 [1\ 0].)Tj 0 Tc -0.036 Tw T* (\223\021\024 \022\026\f\026\036\021\f\016 \022\024\n\002\017\027\026\006\ \017\017 \035\026\036\030\027\024\005 \022\024\026\020\031\035\016\006\017\ \017 \f)Tj /Span<>> BDC ( )Tj EMC (\023\035\026)Tj 0 Tw (-)Tj 0.159 Tw T* (\f\021\017\022\024\005 \r\027\031\021\030\036\027\027\036\020\024 \f\r\017\ \013\036\r\024\020\024 \024\021\r\036\030\f\021\017\016 \f\035\017\017\f\ \021\024-)Tj 0.148 Tw T* [(\n\t\001\036\004\027\t\n )0.5(\035\024\f\022\031\021\024\n, )0.6(\026\032\017\r\035\036\027\017\036 )0.6(\024\021\n\036\004\036\027\024 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 19.666 0 Td (70,2% )Tj 0.434 Tw -19.666 -1.218 Td (\f\035\031\004\026\036\r. \215\030\017)Tj /Span<>> BDC ( )Tj EMC (\f\030\026\r\027\036\027\017\017 \023\024\035\031\004\036\027\027\t\b \030\ \036\031\035\034\021\026\021\024\r )Tj 0.147 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC 0.816 0 Td [(\220\235\235\036\022\021\017\r\027\024\f\021\034\033 )0.5(\n\036\021\024\007\026 )0.6(\035\017\022\r\017\007\026\006\017\017 )0.5(\f\r\017\013\026 )0.5(\023\031\021\036\n )]TJ 0.415 Tw -0.816 -1.218 Td [(\027\017\r\036\007\036\027\017\016 )0.5(\035\024\f\022\031\021\026 \002\036 \017\f\023\024\035\034\024\r\026\027\ \017\016 )0.5(\035\026\036\030\027\024\005 )]TJ 0.403 Tw T* (\022\024\026\020\031\035\016\006\017\017, \021\026\022\032\036 \n\024\032\ \027\024 \031\r\017\007\036\021\034 \007\024\r\024\035\034\027\024 \f\b\024\ )Tj 0 Tw (-)Tj 0.238 Tw T* [(\032\017\036 \023\024\022\026\026\021\036\035\017 \026\032\017\r\035\036\ \027\017\016. \230\026\022, S)15.1(tell)-31(ingwer)-23.9(f)]TJ /Span<>> BDC ( )Tj EMC (M.E. )Tj 0.224 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC [(\f\024\026\r\021. \(2019\) \023\030\024\r\036\035\017 \n\036\021\026\026\ \027\026\035\017 )0.5(\007\026\027\027\t\b, \r)]TJ /Span<>> BDC ( )Tj EMC (\022\024)Tj 0 Tw (-)Tj 0.487 Tw T* (\021\024\030\024\n \f\030\026\r\027\017\r\026\035\017\f\034 \030\036\031\ \035\034\021\026\021\t \035\036\004\036\027\017\016 \f\r\017\013\036\005\ )Tj 0.158 Tw T* (\n\036\021\024\007\024\n LIFT \017)Tj /Span<>> BDC ( )Tj EMC (\n\036\021\024\007\024\n \027\017\r\036\007\036\027\017\016 \035\024\f\022\ \031\021\026. \200)Tj /Span<>> BDC ( )Tj EMC (\030\026)Tj 0 Tw (-)Tj 0.244 Tw T* [(\002\024\021\036 )0.5(\023\030\024\007\036\n\024\027\f\021\030\017\030\024\r\026\027\t )0.6(\f\024\023\024\f\021\026\r\017\n\t\036 )0.5(\023\024\022\026\026\021\036)]TJ 0 Tw (-)Tj 0.207 Tw T* (\035\017 \026\032\017\r\035\036\027\017\016 \f\r\017\013\036\005 \023\030\ \017)Tj /Span<>> BDC ( )Tj EMC (\017\f\023\024\035\034\024\r\026\027\017\017 \007\026\027\027\t\b )Tj 0.246 Tw T* (\021\036\b\027\024\035\024\020\017\005, \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\n \f\030\036\007\027\016\016 \004\026\f\021\024\021\026 \026\ \032\017\r\035\036\027\017\016 )Tj 0.02 Tw T* (\023\030\017)Tj /Span<>> BDC ( )Tj EMC (\027\017\r\036\007\036\027\017\017 \035\024\f\022\031\021\026 \f\024\f\021\ \026\r\017\035\026 74,6% \(65,6\22683,7\) )Tj 0.027 Tw T* ([16]. \207\036\031\f\035\024\r\027\024, \220\021\024 \035\017\001\034 \f\ \030\036\007\027\017\036 \006\017\235\030\t, \023\024\035\031\004\036\027\ )Tj 0 Tw (-)Tj 0.073 Tw T* (\027\t\036 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\024\002\030\026\002\024\021\022\036 \024\021\024\002\030\026\027\027\t\b\ \007\035\016 \n\036\021\026\026\027\026\035\017\026 \023\031)Tj 0 Tw (-)Tj 0.026 Tw T* (\002\035\017\022\026\006\017\005, \024\007\027\026\022\024 \024\027\017 \ \007\024\r\024\035\034\027\024 \004\036\021\022\024 \024\021\030\026\032\ \026\033\021 \r\024)Tj 0 Tw (-)Tj 0.205 Tw T* (\n\024\032\027\024\f\021\017 \n\036\021\024\007\026 \027\017\r\036\007\036\ \027\017\016 \035\024\f\022\031\021\026 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\035\036\004\036\027\017\017 )Tj 0 Tw T* (\f\r\017\013\036\005.)Tj 0.519 Tw T* (\230\026\022\017\n \024\002\030\026\024\n, \023\016\021\017\035\036\021\ \027\017\005 \024\023\t\021 \017\f\023\024\035\034\024\r\026\027\017\016\ )Tj 0.293 Tw T* [(\035\026\036\030\027\024\005 )0.6(\022\024\026\020\031\035\016\006\017\017 )0.5(\023\030\024\007\036\n\024\027\f\021\030\017\030\024\r\026\035 )0.6(\027\036\f\022\024\035\034)]TJ 0 Tw (-)Tj 0.221 Tw T* [(\022\024 \235\026\022\021\024\r: )0.5(\r\027\036 \026\r\017\f\017\n\024\f\021\017 )0.5(\024\021 \r\026\030\017\026\027\021\026 )0.5(\026\022\030\t\021\017\016 )]TJ 0.192 Tw T* (\r\027\031\021\030\036\027\027\036\020\024 \f\r\017\013\036\r\024\020\024\ \024\021\r\036\030\f\021\017\016, \n\036\021\024\007\017\022\026 \035\026\ \036\030)Tj 0 Tw (-)Tj 0.258 Tw T* [(\027\024\005 \022\024\026\020\031\035\016\006\017\017 \f\024\023\030\024\ \r\024\032\007\026\036\021\f\016 )0.5(\027\017\022\024\005 \017\027\021\036\027\f\017\r)]TJ 0 Tw (-)Tj 0.121 Tw T* (\027\024\f\021\034\033 \017)Tj /Span<>> BDC ( )Tj EMC (\027\036\002\024\035\034\001\024\005 \023\030\024\007\024\035\032\017\021\ \036\035\034\027\024\f\021\034\033 \002\024\035\036\r\024\020\024 )Tj 0.23 Tw T* (\f\017\027\007\030\024\n\026; \n\036\021\024\007 \f\024\023\030\016\032\036\ \027 \f)Tj /Span<>> BDC ( )Tj EMC (\024\021\f\031\021\f\021\r\017\036\n \007\035\017\021\036\035\034)Tj 0 Tw (-)Tj 0.329 Tw T* (\027\t\b \024\020\030\026\027\017\004\036\027\017\005 \235\017\017\004\036\ \f\022\024\005 \026\022\021\017\r\027\024\f\021\017 \023\026\006\017\036\ \027)Tj 0 Tw (-)Tj 0.031 Tw T* (\021\024\r; \f\030\036\007\027\016\016 \007\035\017\021\036\035\034\027\024\ \f\021\034 \023\030\036\002\t\r\026\027\017\016 \r)Tj /Span<>> BDC ( )Tj EMC (\f\021\026\006\017\024\027\026\030\036 )Tj 0.16 Tw T* [(\023\024\f\035\036 )0.5(\024\023\036\030\026\006\017\017 )0.5(\f\024\f\021\026\r\035\016\036\021 )0.5(3\2264)]TJ /Span<>> BDC ( )Tj EMC [(\007\027\016 )0.5(\(Me)]TJ /Span<>> BDC ( )Tj EMC 17.735 0 Td (=)Tj /Span<>> BDC ( )Tj EMC 0.893 0 Td (3,5\), \004\021\024 )Tj 0.12 Tw -18.628 -1.218 Td [(\f\r\017\007\036\021\036\035\034\f\021\r\031\036\021 )0.5(\024)]TJ /Span<>> BDC ( )Tj EMC (\021\024\n, \004\021\024 \026)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\026\n\017 \027\036 \021\030\036\002\031)Tj 0 Tw (-)Tj 0.041 Tw T* (\036\021\f\016 \007\035\017\021\036\035\034\027\024\036 \027\026\002\035\ \033\007\036\027\017\036 \r)Tj /Span<>> BDC ( )Tj EMC (\031\f\035\024\r\017\016\b \f\021\026\006\017\024\027\026\030\026, )Tj 0.029 Tw T* (\026)Tj /Span<>> BDC ( )Tj EMC (\n\036\021\024\007\017\022\026 \017\n\036\036\021 \n\026\035\024\017\027\ \r\026\017\r\027\t\005 \b\026\030\026\022\021\036\030 \017)Tj /Span<>> BDC ( )Tj EMC (\n\024\032\036\021 )Tj 0.319 Tw 23.244 64.543 Td (\002\t\021\034 \r\022\035\033\004\036\027\026 \r)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\036\004\036\027\034 \f\021\026\006\017\024\027\026\030\026\ \n\036\013\026\033\013\017\b )Tj 0.11 Tw T* (\021\036\b\027\024\035\024\020\017\005; \f\026\n\026 \023\024)Tj /Span<>> BDC ( )Tj EMC (\f\036\002\036 \035\026\036\030\027\026\016 \022\024\026\020\031\035\016\ \006\017\016 \f\r\017)Tj 0 Tw (-)Tj 0.033 Tw T* (\013\036\r\024\020\024 \b\024\007\026 \016\r\035\016\036\021\f\016 \035\017\ \001\034 \f\024\f\021\026\r\027\024\005 \004\026\f\021\034\033 \024\023\036\ \030\026)Tj 0 Tw (-)Tj 0.003 Tw T* (\006\017\017 \023\024)Tj /Span<>> BDC ( )Tj EMC (\035\017\022\r\017\007\026\006\017\017 \f\r\017\013\026, \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\n \r\026\032\027\036\005\001\031\033 \030\024\035\034 )Tj 0.254 Tw T* (\017\020\030\026\036\021 \027\026\007\036\032\027\024\036 \026\022\030\t\ \021\017\036 \r\027\031\021\030\036\027\027\036\020\024 \f\r\017\013\036\ \r\024\020\024 )Tj 0.154 Tw T* (\024\021\r\036\030\f\021\017\016 \f)Tj /Span<>> BDC ( )Tj EMC (\006\036\035\034\033 \017\024\035\016\006\017\017 \b\024\007\026 \024\021\ \023\030\024\f\r\036\021\026 \023\030\016)Tj 0 Tw (-)Tj 0.125 Tw 0 -1.218 TD (\n\024\005 \022\017\001\022\017. \210\f\035\024\032\027\036\027\017\016 \ \r)Tj /Span<>> BDC ( )Tj EMC (\030\026\027\027\036\n \023\024\f\035\036\024\023\036\030\026\006\017\024\ \027)Tj 0 Tw (-)Tj 0.145 Tw 0 -1.218 TD (\027\024\n \023\036\030\017\024\007\036 \002\t\035\017 \026\235\017\022\ \f\017\030\024\r\026\027\t \035\017\001\034 \r)Tj /Span<>> BDC ( )Tj EMC (3)Tj /Span<>> BDC ( )Tj EMC (\(2,5%\) )Tj 0.065 Tw T* (\f\035\031\004\026\016\b, \004\021\024 \f\r\017\007\036\021\036\035\034\f\ \021\r\031\036\021 \024)Tj /Span<>> BDC ( )Tj EMC (\002\036\024\023\026\f\027\024\f\021\017 \007\026\027\027\024\005 )Tj 0 Tw T* (\n\036\021\024\007\017\022\017.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 303.3769 578.6938 Tm [(\020)21(\026\027\r\242\224\034\022\031\034)]TJ 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0 Tc 0.297 Tw 10 0 0 10 303.3071 554.3378 Tm (\203\026 \f\036\020\024\007\027\016\001\027\017\005 \007\036\027\034 \n\036\ \021\024\007 \035\026\036\030\027\024\005 \022\024\026\020\031\035\016\006\ \017\017 )Tj 0.21 Tw T* (\f\r\017\013\036\005 \026\027\016\035 \f\r\024\033 \027\017\001\031 \f\030\ \036\007\017 \007\030\031\020\017\b \b\017\030\031\030\020\017\004\036)Tj 0 Tw (-)Tj 0.212 Tw T* (\f\022\017\b \f\023\024\f\024\002\024\r \035\036\004\036\027\017\016. \203\ \036\f\n\024\021\030\016 \027\026)Tj /Span<>> BDC ( )Tj EMC (\021\024, \004\021\024 \023\024\035\031)Tj 0 Tw (-)Tj 0.252 Tw T* [(\004\036\027\027\t\036 \030\036\031\035\034\021\026\021\t )0.5(\027\036 \023\030\024\007\036\n\024\027\f\021\030\017\030\024\r\026\035\017\ \027\026\004\017)]TJ 0 Tw (-)Tj 0.196 Tw T* (\n\024\020\024 \023\030\036\r\024\f\b\024\007\f\021\r\026 \n\036\021\024\ \007\017\022\017 \027\026\007 \007\030\031\020\017\n\017 \001\017\030\024\ \022\024 )Tj 0.847 Tw T* (\023\030\017\n\036\027\016\036\n\t\n\017 \r\n\036\001\026\021\036\035\034\ \f\021\r\026\n\017, \017\f\023\024\035\034\024\r\026\027\017\036 )Tj 0.513 Tw T* [(\035\026\036\030\027\024\005 )0.5(\022\024\026\020\031\035\016\006\017\017 )0.6(\023\024\r\024\035\017\035\024 )0.6(\n\017\027\017\n\017\017\030\024\r\026\021\034 )]TJ 0.205 Tw T* [(\021\030\026\r\n\026\021\017\004\036\f\022\024\036 )0.6(\r\024\007\036\005\f\021\r\017\036 )0.5(\027\026)]TJ /Span<>> BDC ( )Tj EMC 13.996 0 Td [(\021\022\026\027\017 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 3.726 0 Td (\n\t\001\036\004\027\t\036 )Tj 0.065 Tw -17.722 -1.218 Td (\r\024\035\024\022\027\026 \f\235\017\027\022\021\036\030\026. \204\036\021\ \024\007\017\022\026 \023\024\022\026\026\035\026 \f\r\024\036 \023\024\ \035\027\024\036 )Tj 0.054 Tw T* [(\f\024\024\021\r\036\021\f\021\r\017\036 \021\026\022\017\n \023\024\027\ \016\021\017\016\n, )0.5(\022\026\022 \n\026\035\024\017\027\r\026\017\r\027\024\f\021\034 )]TJ -0.044 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC [(\f\235\017\027\022\021\036\030\024\f\002\036\030\036\020\026\033\013\017\ \005 )0.5(\b\026\030\026\022\021\036\030. \212\026\035\034\027\036\005\001\036\036\ \030\026)]TJ 0 Tw (-)Tj -0.03 Tw T* (\r\017\021\017\036 \007\026\027\027\024\005 \021\036\b\027\024\035\024\020\ \017\017 \n\024\032\036\021 \002\t\021\034 \f\r\016\026\027\024 \f)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\036\036 )Tj 0.063 Tw T* (\027\026\007\036\032\027\t\n \026\022\030\t\021\017\036\n \r\027\031\021\ \030\036\027\027\036\020\024 \f\r\017\013\036\r\024\020\024 \024\021\r\036\ \030)Tj 0 Tw (-)Tj -0.017 Tw T* (\f\021\017\016, \004\021\024 \023\024\r\024\035\017\021 \r)Tj /Span<>> BDC ( )Tj EMC (\023\024\035\027\024\005 \n\036\030\036 \030\036\026\035\017\024\r\026\021\ \034 \021\036 \023\030\036)Tj 0 Tw (-)Tj 0.075 Tw T* (\017\n\031\013\036\f\021\r\026, \022\024\021\024\030\t\n\017 \024\002\035\ \026\007\026\036\021 \035\026\036\030\027\026\016 \022\024\026\020\031\035\ \016\006\017\016 )Tj 0.007 Tw T* (\021\022\026\027\036\005 \f)Tj /Span<>> BDC ( )Tj EMC (\n\017\027\017\n\026\035\034\027\t\n \030\017\f\022\024\n \030\026\r\017\ \021\017\016 \023\024\f\035\036\024\023\036\030\026)Tj 0 Tw (-)Tj T* (\006\017\024\027\027\t\b \024\f\035\024\032\027\036\027\017\005.)Tj /T1_2 1 Tf 0.023 Tw 0 -2.436 TD (\223\030\032\255\020\034\036 \032\026\020\017\022\017\026)Tj /T1_0 1 Tf 0.184 Tw 0 -1.218 TD [(\025)-4.1(\024)-4.3(\027)1.7(\006)-6(\036)-6.8(\023)2.2(\006)-6(\017)-5.4(\016 \017)]TJ /Span<>> BDC ( )Tj EMC [(\007)-6(\017)2.7()-9.9(\026\005)1.7(\027 \017)-2.3(\f)3.1(\f)-38.9(\035)-6.8(\036)-19(\007)-4.4(\024)-4.3(\r)-8.9(\026\027)1.7(\017)-5.5(\016)13.7(:)]TJ /T1_3 1 Tf [( \222)15.6(\n)-0.8(\t\024)6.9(\026)1.8(\032\031)6.6(\027)]TJ /Span<>> BDC ( )Tj EMC [(\215)28.8(.)28.5(\216)24.3(.)7.8(, )]TJ -0.011 Tc 0.011 Tw T* [(\221\026)-25.4(\004)-3.4(\026)-9.2(\032\002)-0.8(\021)]TJ /Span<>> BDC 3.248 0 Td ( )Tj EMC [(\201)-13.3(.)17.5(\216)13.3(.)]TJ /T1_0 1 Tf 0 Tc 0.768 Tw -3.248 -1.218 Td [(\221)-4.6(\002)-9.9(\024)0.7(\030 \017)]TJ /Span<>> BDC ( )Tj EMC [(\024)-11.8(\002)3(\030)-11.4(\026)-6.3(\002)-9.9(\024)-10.9(\021)-17.7(\022)-19.1(\026 \n)1.3(\026)-11.8(\021)-9.9(\036)-1.7(\030)-7.6(\017)-0.6(\026)-33.1(\035)-2.5(\024)-4.3(\r)10.4(:)]TJ /T1_3 1 Tf -0.011 Tc 0.779 Tw [( \221\026)-25.4(\004)-3.4(\026)-9.2(\032\002)-0.8(\021)]TJ /Span<>> BDC 19.293 0 Td ( )Tj EMC [(\201)-13.3(.)17.5(\216)13.4(.)-3.2(,)-11( )]TJ 0 Tc 0 Tw -19.293 -1.218 Td [(\222)15.6(\n)-0.8(\t\024)6.9(\026)1.9(\032\031)6.6(\027)]TJ /Span<>> BDC ( )Tj EMC [(\215)28.8(.)28.5(\216)24.3(.)]TJ /T1_0 1 Tf 0.018 Tc 1.726 Tw T* [(\221)35.2(\021)-3.5(\026)6.2(\021\017)15.6(\f)-18(\021\017)22.5(\004)9.8(\036)7.6(\f)16.4(\022)-1.1(\026)-3(\016)18( \024)6.2(\002)21(\030)6.6(\026)11.7(\002)8.1(\024)7.1(\021\022)-1.1(\026)21.7(:)]TJ /T1_3 1 Tf -0.011 Tc 1.755 Tw 13.093 0 Td [( \221\026)-25.4(\004)-3.4(\026)-9.1(\032\002)-0.8(\021)]TJ /Span<>> BDC 5.225 0 Td ( )Tj EMC [(\201)-13.3(.)17.5(\216)13.3(.)-3.2(,)-11( )]TJ 0 Tc 0 Tw -18.318 -1.218 Td [(\222)15.6(\n)-0.8(\t\024)6.9(\026)1.9(\032\031)6.6(\027)]TJ /Span<>> BDC ( )Tj EMC [(\215)28.8(.)28.5(\216)24.3(.)]TJ /T1_0 1 Tf 0.002 Tc -0.002 Tw T* [(\203)7.2(\026\023)4.2(\017\f)-10.8(\026)1.7(\027)3.7(\017)-6.7(\036)2.1( \021)-7.9(\036)-3.4(\022\f)-34(\021)-19.5(\026)5.7(:)]TJ /T1_3 1 Tf 0 Tc 0 Tw 7.694 0 Td [( \222)15.6(\n)-0.8(\t\024)6.9(\026)1.9(\032\031)6.6(\027)]TJ /Span<>> BDC ( )Tj EMC [(\215)28.8(.)28.5(\216)24.3(.)7.8(, \221)11(\026)-14.4(\004)7.6(\026)1.8(\032)10.7(\002)10.2(\021)]TJ /Span<>> BDC ( )Tj EMC [(\201)-2.3(.)28.6(\216)24.3(.)7.8(,)]TJ /T1_0 1 Tf -7.694 -1.218 Td [(\217)5.5(\036)-19(\007)-20.1(\026\022)-32.6(\021)-17.7(\017)1.5(\030)-11.8(\024)-4.4(\r)-8.8(\026\027)1.8(\017)-8.7(\036)6.5(:)]TJ /T1_3 1 Tf 0.55 Tw [( \220)52.8(\025)7.7(\024)4.1(\n)9.6(\027)]TJ /Span<>> BDC ( )Tj EMC [(\201)-2.3(.)27.5(\223)26.7(.)7.8(, \213)3.8(\023)9(\026)12.2(\202)3.7(\n\030)4.9(\026)1.8(\032)5.4(\021)7.7(\020)10.1(\017)]TJ /Span<>> BDC ( )Tj EMC [(\035)25(.)7.4(\201)-2.3(.)7.8(, )]TJ 0 Tw T* [(\240)8.4(\205)7.1(\030)2.7(\032\n)9.6(\027)]TJ /Span<>> BDC ( )Tj EMC [(\201)-2.2(.)7.3(\201)-2.3(.)7.8(, \222)16.6(\025)3.3(\t)9.8(\031)-20.6(\023)3.4(\031)6.6(\027)]TJ /Span<>> BDC ( )Tj EMC [(\200)1.4(.)43.7(\255)27.6(.)]TJ /T1_2 1 Tf 0.023 Tw 0 -2.436 TD (AUTHORS CONTRIBUTION)Tj /T1_0 1 Tf 0.27 Tw 0 -1.218 TD [(C)-6.5(o)0.8(nce)-0.7(p)-12.3(t a)2.4(n)-4.6(d d)-5.5(e)-13.3(s)-16.6(i)3.2(g)1.2(n o)-2.2(f t)-16.6(h)-5.3(e s)-20(t)-12.8(ud)-10.9(y)-11.8(:)]TJ /T1_3 1 Tf [( I)14(v)10.8(a)-0.8(n)]TJ /Span<>> BDC ( )Tj EMC [(V)53.1(.)]TJ /Span<>> BDC ( )Tj EMC [(K)13.3(o)3.4(s)-10.8(t)2.4(ar)2.4(e)-4(v)33.6(, )]TJ -0.005 Tc 0.005 Tw T* [(A)-1.4(le)-33.6(xa)-5.8(n)-5.6(d)-6(e)-6.7(r)]TJ /Span<>> BDC 3.884 0 Td ( )Tj EMC [(V)48.1(.)]TJ /Span<>> BDC 0.955 0 Td ( )Tj EMC [(Z)0.6(a)-3.3(kha)-4.8(r)-45.2(y)-1.1(a)-5.9(n)]TJ /T1_0 1 Tf 0 Tc 1.014 Tw -4.839 -1.218 Td [(C)-6.5(o)-5.8(l)-19(l)-14.3(e)-9.4(c)-32.5(t)-37.3(i)3.2(o)0.8(n )0.5(a)2.4(n)-4.6(d )0.6(p)-3.8(r)-6(o)-7(ce)-13.3(s)-12.8(s)-16.6(i)7.1(n)-1.9(g )0.6(o)-2.2(f )0.6(t)-16.7(h)-5.3(e )0.5(m)1.8(a)-8.4(t)-15.1(e)-2.1(r)-48(i)5.1(a)-1.5(l)-22.5(:)]TJ /T1_3 1 Tf 0 Tw ( )Tj T* [(A)3.6(l)4.8(e)-28.6(x)5(a)-0.8(n)-0.6(d)-1(e)-1.6(r)]TJ /Span<>> BDC ( )Tj EMC [(V)53.1(.)]TJ /Span<>> BDC ( )Tj EMC [(Z)5.6(a)1.8(k)5.3(h)4.8(ar)-40.2(y)3.8(a)-0.8(n)-6(, I)14(v)10.8(a)-0.8(n)]TJ /Span<>> BDC ( )Tj EMC [(V)53.2(.)]TJ /Span<>> BDC ( )Tj EMC [(K)13.3(o)3.3(s)-10.7(t)2.3(ar)2.4(e)-3.9(v)]TJ /T1_0 1 Tf -0.007 Tc 0.859 Tw T* [(St)-34.7(a)-15.4(t)-44.4(i)-4.3(s)-27(t)-44.4(i)-1.8(c)-18.8(a)-8.5(l)-7( p)-10.8(r)-13(o)-14(c)-6.8(e)-20.3(s)-19.8(s)-23.5(in)-8.9(g)1.9(:)]TJ /T1_3 1 Tf -0.005 Tc 0.857 Tw 9.94 0 Td [( A)-1.4(le)-33.6(xa)-5.8(n)-5.6(d)-6(e)-6.7(r)]TJ /Span<>> BDC 4.969 0 Td ( )Tj EMC [(V)48.1(.)]TJ /Span<>> BDC 1.807 0 Td ( )Tj EMC [(Z)0.6(a)-3.3(kha)-4.8(r)-45.2(y)-1.1(a)-5.9(n)-11(,)-5( )]TJ 0 Tc 0 Tw -16.717 -1.218 Td [(I)14(v)10.8(a)-0.8(n)]TJ /Span<>> BDC ( )Tj EMC [(V)53.2(.)]TJ /Span<>> BDC ( )Tj EMC [(K)13.4(o)3.3(s)-10.7(t)2.3(ar)2.4(e)-4(v)]TJ /T1_0 1 Tf 1.263 Tw T* [(W)3.1(r)-48(i)-6(t)-37.4(i)7.1(n)-1.9(g )0.5(o)-2.2(f t)-16.7(h)-5.3(e t)-15.2(e)-23.9(x)-35.9(t)-20.1(:)]TJ /T1_3 1 Tf [( I)14(v)10.8(a)-0.8(n)]TJ /Span<>> BDC ( )Tj EMC 16.393 0 Td [(V)53.1(.)]TJ /Span<>> BDC ( )Tj EMC [(K)13.3(o)3.4(s)-10.7(t)2.3(ar)2.4(e)-4(v)33.6(, )]TJ -0.005 Tc 0.005 Tw -16.393 -1.218 Td [(A)-1.4(le)-33.6(xa)-5.8(n)-5.6(d)-6(e)-6.7(r)]TJ /Span<>> BDC 3.884 0 Td ( )Tj EMC [(V)48.1(.)]TJ /Span<>> BDC 0.955 0 Td ( )Tj EMC [(Z)0.6(a)-3.3(kha)-4.8(r)-45.2(y)-1.1(a)-5.9(n)]TJ /T1_0 1 Tf 0.006 Tc -0.006 Tw -4.839 -1.218 Td [(E)11.6(dit)-31.4(i)13.1(n)4.1(g)15(:)]TJ /T1_3 1 Tf 0 Tc 0.374 Tw 3.238 0 Td [( A)3.6(l)4.8(e)-28.6(x)5(a)-0.8(n)-0.6(d)-1(e)-1.6(r)]TJ /Span<>> BDC ( )Tj EMC [(Y)33.7(u)7.7(. T)-2.7(i)0.9(t)1.4(o)-0.6(v)33.6(, L)-3.6(e)-6.2(o)0.5(n)6.1(i)3.1(d)]TJ /Span<>> BDC ( )Tj EMC [(A)-12.6(.)]TJ /Span<>> BDC ( )Tj EMC [(B)5.1(l)3.3(a)-0.8(g)-2.5(o)-7.8(d)1.9(ar)-14.6(n)6.2(y)16.5(, )]TJ 0 Tw -3.238 -1.218 Td [(A)3.8(n)-0.6(d)5.2(r)2.4(e)-2.5(y)]TJ /Span<>> BDC ( )Tj EMC [(A)-12.5(.)]TJ /Span<>> BDC ( )Tj EMC [(M)5.6(u)-1.6(d)5.2(r)2.4(o)-0.6(v)33.6(, D)-1.9(m)5.8(i)0.9(t)-5.4(r)-40.2(y)]TJ /Span<>> BDC ( )Tj EMC [(O)13.1(.)]TJ /Span<>> BDC ( )Tj EMC [(K)11(i)11(s)4.9(e)-1.9(l)4.8(e)-4(v)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\033\030\031\030\213\b)-20.9(\035\231\213\233\t \021\032)50(\b)42(\032\231\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj -51.938 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 23, \023\0221)69(, 202)69(4)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 23, \023\0221)69(, 202)69(4)]TJ /T1_5 1 Tf 25 0 0 25 28.14 56.0378 Tm (68)Tj ET endstream endobj 1872 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\034\205\026\220\007\016\026\001\220\203 \025\221\020\026 \221\002\220\024\ \016\001\016\001\220\205 \024\016\026)11.1(\025\201\013 \007\013\222\016\002\001\025\203 \n)10(\025\013\202)-20(\215\007\205\227\220\220 )]TJ 0 -1 TD [(\221\002\220\022\007\016\017\016\001\220\220 \026\002\013\001\006- \220\022\ \232\n\006)-10(\026\002\013\006\225\220\001\n)-9.9(\026)11(\016\002\001\020\207 \006\r\220\224\016\203 \221\002\205\024\025\203 \n\220\ \n\220)]TJ 37.587 1 Td [(Fiv)12(e)-52(-y)10(ear e)21(xperience of laser coagulation in th)11(e tr)31(eatment )]TJ 6.214 -1 Td [(of tr)21.1(ans- and supr)21.1(asphincteric anal f)-20.9(istulas)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0.527 Tw 10 0 0 10 42.5197 517.8039 Tm [(\023\036\030\036\r\016\t\r\026\036\021\f\016 )0.5(\004\026\f\021\034 \f\r\017\013\026 \r)]TJ /Span<>> BDC ( )Tj EMC (\n\036\032\f\235\017\027\022\021\036\030\027\024\n )Tj 0.13 Tw 0 -1.218 TD [(\023\030\024\f\021\030\026\027\f\021\r\036, )0.5(\023\030\017\r\024\007\017\035\024 \022)]TJ /Span<>> BDC ( )Tj EMC [(\r\024\024\002\027\024\r\035\036\027\017\033 )0.5(\f\024\024\002\013\036)]TJ 0 Tw (-)Tj 0.044 Tw T* [(\027\017\016 )0.6(\022\017\001\022\017 )0.5(\f\024 )0.5(\f\r\017\013\036\r\t\n )0.6(\b\024\007\024\n. )0.5(\200\036\030\024\016\021\027\036\036 )0.6(\r\f\036\020\024, )0.5(\220\021\024 )]TJ 0.214 Tw T* [(\024\002\255\016\f\027\016\036\021\f\016 )0.5(\024\021\f\031\021\f\021\r\017\036\n \022\026\022\024\020\024-\035\017\002\ \024 \007\036\005\f\021\r\017\016 )0.5(\027\036)]TJ 0 Tw (-)Tj 0.241 Tw T* (\023\024\f\030\036\007\f\021\r\036\027\027\024 \027\026)Tj /Span<>> BDC ( )Tj EMC (\r\027\031\021\030\036\027\027\036\036 \f\r\017\013\036\r\024\036 \024\021\ \r\036\030\f\021\017\036, )Tj 0.071 Tw T* (\021\036\n \f\026\n\t\n \036\020\024 \001\017\030\017\027\026, \023\030\036\ \r\t\001\026\033\013\026\016 \007\017\026\n\036\021\030 3 \n\n, )Tj 0.225 Tw T* (\031)Tj /Span<>> BDC ( )Tj EMC (\004\026\f\021\017 \023\026\006\017\036\027\021\024\r \f\023\024\f\024\002\ \f\021\r\024\r\026\035\026 \023\024\r\021\024\030\027\024\n\031 \023\024\ )Tj 0 Tw (-)Tj 0.147 Tw T* [(\016\r\035\036\027\017\033 )0.6(\f\024\024\002\013\036\027\017\016 )0.6(\n\036\032\007\031 )0.5(\023\030\024\f\r\036\021\024\n )0.5(\023\030\016\n\024\005 )0.6(\022\017\001)]TJ 0 Tw (-)Tj 0.241 Tw T* (\022\017 \017)Tj /Span<>> BDC ( )Tj EMC (\f\r\017\013\036\r\t\n \b\024\007\024\n, \027\036\f\n\024\021\030\016 \027\ \026)Tj /Span<>> BDC ( )Tj EMC (\036\020\024 \023\036\030\036\r\016\022\031 )Tj 0.284 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\n\036\032\f\235\017\027\022\021\036\030\027\024\n \023\030\024\f\021\030\ \026\027\f\021\r\036. \230\026\022\032\036 \r)Tj /Span<>> BDC ( )Tj EMC (\007\026\027\027\024\005 )Tj 0.149 Tw T* (\020\030\031\023\023\036 \002\024\035\034\027\t\b \002\t\035\017 \007\024\ \f\021\017\020\027\031\021\t \002\024\035\036\036 \b\031\007\001\017\036\ \030\036)Tj 0 Tw (-)Tj 0.082 Tw T* (\031\035\034\021\026\021\t \026\032\017\r\035\036\027\017\016 \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \032\036\027\f\022\024\020\024 \023\024\ \035\026)Tj /Span<>> BDC ( )Tj EMC (\227 )Tj -0.004 Tw T* (57%, \023\024)Tj /Span<>> BDC ( )Tj EMC (\f\030\026\r\027\036\027\017\033 \f)Tj /Span<>> BDC ( )Tj EMC (86% \031)Tj /Span<>> BDC ( )Tj EMC (\n\031\032\004\017\027, \024\007\027\026\022\024 \030\026\035\017\004\017\ \016 )Tj -0.022 Tw T* (\023\030\017)Tj /Span<>> BDC ( )Tj EMC (\007\026\027\027\024\n \024\002\255\036\n\036 \r\t\002\024\030\022\017 \027\ \036 \007\024\f\021\017\020\035\017 \f\021\026\021\017\004\036\f\022\024\ \005 )Tj 0 Tw T* (\027\026\004\017\n\024\f\021\017 \()Tj /T1_2 1 Tf (p)Tj /T1_1 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,054\).)Tj 0.014 Tc 0.23 Tw T* (\215\030\017 \024\002\024\002\013\036\027\017\017 \007\026\027\027\t\b \017\ )Tj /Span<>> BDC ( )Tj EMC (\r\f\036\b 3 \020\030\031\023\023 \017)Tj /Span<>> BDC ( )Tj EMC (\024\006\036\027)Tj 0 Tc 0 Tw (-)Tj 0.014 Tc 0.194 Tw T* (\022\036 \r\035\017\016\027\017\016 \031\022\026\026\027\027\t\b \r\t\001\ \036 \235\026\022\021\024\030\024\r \027\026)Tj /Span<>> BDC ( )Tj EMC [(\004\026\f\021\024\021\031)14( )]TJ 0.5 Tw T* (\026\032\017\r\035\036\027\017\016, \002\t\035\024 \031\f\021\026\027\024\ \r\035\036\027\024, \004\021\024 \036\007\017\027\f\021\r\036\027)Tj 0 Tc 0 Tw (-)Tj 0.014 Tc 0.236 Tw T* [(\027\t\n \235\026\022\021\024\030\024\n, \f\021\026\021\017\f\021\017\004\ \036\f\022\017 \027\026\004\017\n\024 \r\035\017\016\033\013\017\n)14( )]TJ 0.307 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC [(\004\026\f\021\024\021\031 \023\024\035\024\032\017\021\036\035\034\027\t\ \b \030\036\031\035\034\021\026\021\024\r, \016\r\035\016\036\021\f\016\ )14( )]TJ 0.454 Tw T* [(\007\017\026\n\036\021\030 \r\027\031\021\030\036\027\027\036\020\024 \f\ \r\017\013\036\r\024\020\024 \024\021\r\036\030\f\021\017\016. \230\026\022\ )14( )]TJ 0.071 Tw T* (\023\030\017)Tj /Span<>> BDC ( )Tj EMC (\007\017\026\n\036\021\030\036 \f\r\017\013\036\r\024\020\024 \024\021\r\ \036\030\f\021\017\016 \002\024\035\036\036 3 \n\n \023\024)Tj 0 Tc 0 Tw (-)Tj 0.014 Tc 0.043 Tw T* [(\035\024\032\017\021\036\035\034\027\t\005 \030\036\031\035\034\021\026\ \021 )0.5(\002\t\035 \007\024\f\021\017\020\027\031\021 \031)]TJ /Span<>> BDC ( )Tj EMC (24)Tj /Span<>> BDC ( )Tj EMC 18.842 0 Td [(\(54,5%\))14( )]TJ 0.008 Tw -18.842 -1.218 Td (\017)Tj /Span<>> BDC ( )Tj EMC (44 \023\026\006\017\036\027\021\024\r, \026)Tj /Span<>> BDC ( )Tj EMC (\023\030\017 \007\017\026\n\036\021\030\036 \024\021\r\036\030\f\021\017\ \016)Tj /Span<>> BDC ( )Tj EMC (\252)Tj /Span<>> BDC ( )Tj EMC (3,0)Tj /Span<>> BDC ( )Tj EMC [(\n\n)14( )]TJ 0.219 Tw T* (\f\r\017\013\036\r\024\005 \b\024\007 \026\032\017\035 \r)Tj /Span<>> BDC ( )Tj EMC (58)Tj /Span<>> BDC ( )Tj EMC (\(75,3%\) \017)Tj /Span<>> BDC ( )Tj EMC [(77 \f\035\031\004\026\036\r)14( )]TJ 0 Tc 0 Tw T* (\()Tj /T1_2 1 Tf 0.384 0 Td (\032)Tj /T1_1 1 Tf 0.014 Tc /Span<>> BDC 0.492 0 Td ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,025\).)Tj 0 Tc 0.189 Tw -0.876 -1.218 Td (\215\030\017 \024\006\036\027\022\036 \002\024\035\036\r\024\020\024 \f\017\ \027\007\030\024\n\026 \r)Tj /Span<>> BDC ( )Tj EMC (\023\024\f\035\036\024\023\036\030\026\006\017\024\027)Tj 0 Tw (-)Tj 0.245 Tw T* (\027\024\n \023\036\030\017\024\007\036 \f\021\026\021\017\004\036\f\022\ \017 \027\026\004\017\n\024\005 \030\026\027\017\006\t \n\036\032\007\031\ )Tj 0.266 Tw T* (\020\030\031\023\023\026\n\017 \027\036 \r\t\016\r\035\036\027\024. \200\ )Tj /Span<>> BDC ( )Tj EMC (\023\036\030\r\t\036 \f\031\021\022\017 \017\027\021\036\027\f\017\r)Tj 0 Tw (-)Tj -0.024 Tw T* (\027\024\f\021\034 \002\024\035\017, \r)Tj /Span<>> BDC ( )Tj EMC (\f\030\036\007\027\036\n, \f\024\f\021\026\r\035\016\036\021 3,0\2264,0 \ \(1\2268\) \002\026\035\035\026 )Tj 0.049 Tw T* (\023\024)Tj /Span<>> BDC ( )Tj EMC (\200\202\234, \022)Tj /Span<>> BDC ( )Tj EMC (5-\n \f\031\021\022\026\n \023\024\f\035\036 \024\023\036\030\026\006\017\ \017 \002\024\035\036\r\024\005 \f\017\027\007)Tj 0 Tw (-)Tj 0.022 Tw T* [(\030\024\n, )0.6(\r)]TJ /Span<>> BDC ( )Tj EMC 2.741 0 Td [(\f\030\036\007\027\036\n, )0.6(\f\024\f\021\026\r\035\016\035 )0.6(2,0 )0.6(\002\026\035\035\026 )0.6(\(0\2266\), )0.5(\026)]TJ /Span<>> BDC ( )Tj EMC 15.786 0 Td [(\022 )0.6(10 )0.5(\f\031\021)]TJ 0 Tw (-)Tj -18.526 -1.218 Td (\022\026\n \f\024\f\021\026\r\017\035 0,5 \002\026\035\035\026 \(0\2264\)\ .)Tj 0.149 Tw T* (\230\026\022\032\036 \023\030\024\r\024\007\017\035\024\f\034 \026\027\022\ \036\021\017\030\024\r\026\027\017\036 \023\026\006\017\036\027\021\024\r\ \f)Tj /Span<>> BDC ( )Tj EMC (\023\024)Tj 0 Tw (-)Tj 0.601 Tw T* [(\n\024\013\034\033 \001\022\026\035\t \026\027\026\035\034\027\024\005 \017\ \027\022\024\027\021\017\027\036\027\006\017\017 W)22(e)-18(xner )]TJ 0.023 Tw T* (\(0)Tj /Span<>> BDC ( )Tj EMC (\002\026\035\035\024\r)Tj /Span<>> BDC ( )Tj EMC (\227 \027\024\030\n\026\035\034\027\026\016 \235\031\027\022\006\017\016\ \007\036\030\032\026\027\017\016, 20)Tj /Span<>> BDC ( )Tj EMC (\002\026\035)Tj 0 Tw (-)Tj 0.355 Tw T* (\035\024\r)Tj /Span<>> BDC ( )Tj EMC 2.036 0 Td [(\227 )0.5(\027\036\007\036\030\032\026\027\017\036 )0.6(\r\f\036\b )0.5(\022\024\n\023\024\027\036\027\021\024\r )0.6(\022\017\001\036\004\027\024\020\024 )]TJ 0.256 Tw 21.208 43.841 Td (\f\024\007\036\030\032\017\n\024\020\024 \f)Tj /Span<>> BDC ( )Tj EMC (\027\026\030\031\001\036\027\017\036\n \022\026\004\036\f\021\r\026 \032\ \017\027\017 \017)Tj /Span<>> BDC ( )Tj EMC (\027\036)Tj 0 Tw (-)Tj 0.553 Tw T* (\024\002\b\024\007\017\n\024\f\021\034\033 \030\036\020\031\035\016\030\027\ \024\020\024 \027\024\001\036\027\017\016 \023\030\024\022\035\026\007\024\ \022\). )Tj 0.274 Tw T* (\200)Tj /Span<>> BDC ( )Tj EMC (\030\036\031\035\034\021\026\021\036 \026\027\026\035\017\026 \023\024\ \022\026\026\021\036\035\036\005 \023\024)Tj /Span<>> BDC ( )Tj EMC (\001\022\026\035\036 \002\t\035\024 )Tj 0.027 Tw T* (\031\f\021\026\027\024\r\035\036\027\024, \004\021\024 \007\026\027\027\t\ \036 \n\036\021\024\007\017\022\017 \027\036 \024\022\026\t\r\026\033\021\ \r\t)Tj 0 Tw (-)Tj 0.046 Tw T* (\030\026\032\036\027\027\024\020\024 \r\035\017\016\027\017\016 \027\026\ )Tj /Span<>> BDC ( )Tj EMC (\235\031\027\022\006\017\033 \007\036\030\032\026\027\017\016 \022\017\001\ \036\004\027\024)Tj 0 Tw (-)Tj 0.072 Tw T* (\020\024 \f\024\007\036\030\032\017\n\024\020\024. \211\030\024\r\036\027\ \034 \002\026\035\035\024\r \007\024)Tj /Span<>> BDC ( )Tj EMC (\024\023\036\030\026\006\017\017 \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\017 )Tj 0.09 Tw T* (\024\006\036\027\022\036 \004\036\030\036 3 \n\036\f\016\006\026 \023\024\ \f\035\036 \r\n\036\001\026\021\036\035\034\f\021\r\026 \f\021\026\021\017\ \f)Tj 0 Tw (-)Tj 0.126 Tw T* (\021\017\004\036\f\022\017 \027\026\004\017\n\024 \027\036 \024\021\035\ \017\004\026\035\f\016 \027\036\026\r\017\f\017\n\024 \024\021 \r\026\030\ \017)Tj 0 Tw (-)Tj 0.385 Tw T* (\026\027\021\026 \026\022\030\t\021\017\016 \r\027\031\021\030\036\027\027\ \036\020\024 \f\r\017\013\036\r\024\020\024 \024\021\r\036\030\f\021\017\ \016. )Tj 0.044 Tw T* (\215\024\035\031\004\036\027\027\t\036 \007\026\027\027\t\036 \027\026\030\ \016\007\031 \f)Tj /Span<>> BDC ( )Tj EMC (\023\026\030\026\n\036\021\030\026\n\017 \007\026\r\035\036\027\017\016 \ )Tj 0.055 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\026\027\026\035\034\027\024\n \022\026\027\026\035\036 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\f\235\017\027\022\021\036\030\024\n\036\021\030\017\017 \f\r\017\007\036\ \021\036\035\034)Tj 0 Tw (-)Tj 0.176 Tw T* (\f\021\r\031\036\021 \024\002 \024\021\f\031\021\f\021\r\017\017 \r\t\030\ \026\032\036\027\027\024\020\024 \r\035\017\016\027\017\016 \r\n\036\001\ \026)Tj 0 Tw (-)Tj 0.068 Tw T* [(\021\036\035\034\f\021\r )0.5(\027\026)]TJ /Span<>> BDC ( )Tj EMC 4.628 0 Td [(\235\031\027\022\006\017\024\027\026\035\034\027\024\036 )0.6(\f\024\f\021\024\016\027\017\036 )0.5(\003\202\215\025 )0.6(\027\036\026\r\017)]TJ 0 Tw (-)Tj 0.174 Tw -4.628 -1.218 Td (\f\017\n\024 \024\021 \r\026\030\017\026\027\021\026 \026\022\030\t\021\ \017\016 \r\027\031\021\030\036\027\027\036\020\024 \f\r\017\013\036\r\024\ \020\024 )Tj 0 Tw T* (\024\021\r\036\030\f\021\017\016 \(\230\026\002\035.)Tj /Span<>> BDC ( )Tj EMC (4\).)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 275.0305 310.7779 Tm [(\037\036)10(\032\223\212\226\034\022\031\034)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0.189 Tw 10 0 0 10 274.9606 286.4219 Tm [(\202\027\026\035\017 )0.5(\030\036\031\035\034\021\026\021\024\r )0.5(\035\036\004\036\027\017\016 )0.5(\023\030\017)]TJ /Span<>> BDC ( )Tj EMC 14.798 0 Td [(\f\030\024\022\026\b )0.5(\027\026\002\035\033\007\036)]TJ 0 Tc 0 Tw (-)Tj 0.01 Tc 0.222 Tw -14.798 -1.218 Td (\027\017\016 \026)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\026\n\017, \023\030\036\r\t\001\026\033\013\ \017\b 3 \n\036\f\016\006\026, \023\030\024)Tj 0 Tc 0 Tw (-)Tj 0.01 Tc 0.344 Tw T* [(\007\036\n\024\027\f\021\030\017\030\024\r\026\035, \004\021\024 \035\026\ \036\030\027\026\016 \022\024\026\020\031\035\016\006\017\016 \f\r\017\013\ \026)10( )]TJ 0.058 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\022\024\n\002\017\027\026\006\017\017 \f)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\036\r\016\022\024\005 \f\r\017\013\036\r\024\020\024 \b\024\ \007\026 \r)Tj /Span<>> BDC ( )Tj EMC (\n\036\032)Tj 0 Tc 0 Tw (-)Tj 0.01 Tc 0.541 Tw T* [(\f\235\017\027\022\021\036\030\027\024\n \023\030\024\f\021\030\026\027\f\ \021\r\036 \023\024\022\026\026\035\026 \027\026\017\035\031\004\001\017\ \036)10( )]TJ 0.221 Tw T* [(\030\036\031\035\034\021\026\021\t \f\030\036\007\017 \f\023\024\f\024\002\ \024\r \026\022\030\t\021\017\016 \r\027\031\021\030\036\027\027\036\020\ \024)10( )]TJ 0.161 Tw T* [(\f\r\017\013\036\r\024\020\024 \024\021\r\036\030\f\021\017\016 \(\004\026\ \f\021\024\021\026 \026\032\017\r\035\036\027\017\016 \f\r\017\013\036\005\ )10( )]TJ 0.011 Tw T* [(76,7%\). )0.5(\230\036\n )0.5(\027\036 )0.5(\n\036\027\036\036, )0.5(\f\021\026\021\017\f\021\017\004\036\f\022\017\005 )0.5(\026\027\026\035\017 )0.5(\027\036 )0.5(\r\t)]TJ 0 Tc 0 Tw (-)Tj 0.01 Tc 0.322 Tw T* [(\016\r\017\035 \027\026\004\017\n\t\b \023\030\036\017\n\031\013\036\f\021\ \r \007\026\027\027\024\005 \022\024\n\002\017\027\026\006\017\017)10( )]TJ 0.139 Tw T* (\023\036\030\036\007 \035\026\036\030\027\024\005 \022\024\026\020\031\035\ \016\006\017\036\005 \r)Tj /Span<>> BDC ( )Tj EMC (\f\024\004\036\021\026\027\017\017 \f)Tj /Span<>> BDC ( )Tj EMC (\027\017\r\036)Tj 0 Tc 0 Tw (-)Tj 0.01 Tc 0.279 Tw T* (\007\036\027\017\036\n \f\035\017\017\f\021\024-\n\t\001\036\004\027\024\ \020\024 \035\024\f\022\031\021\026 \(\004\026\f\021\024\021\026 \026)Tj 0 Tc 0 Tw (-)Tj 0.01 Tc 0.044 Tw T* [(\032\017\r\035\036\027\017\016 )0.5(70,2%\). )0.5(\207\024\035\036\036 )0.5(\021\024\020\024, )0.5(\023\030\017)]TJ /Span<>> BDC ( )Tj EMC 14.835 0 Td [(\021\036\b )0.5(\030\026\n\036\030\026\b )0.5(\r\t)]TJ 0 Tc 0 Tw (-)Tj 0.01 Tc 0.17 Tw -14.835 -1.218 Td (\002\024\030\024\022, \r\022\035\033\004\036\027\027\t\b \r)Tj /Span<>> BDC ( )Tj EMC [(\f\030\026\r\027\017\021\036\035\034\027\t\005 \026\027\026\035\017, \002\ \t\035\026)10( )]TJ 0.181 Tw T* (\026\235\017\022\f\017\030\024\r\026\027\026 \035\017\001\034 \021\036\027\ \007\036\027\006\017\016 \r)Tj /Span<>> BDC ( )Tj EMC [(\023\024\035\034\031 2-\b \220\021\017\b)10( )]TJ 0.091 Tw T* (\r\026\030\017\026\027\021\024\r \026\022\030\t\021\017\016 \r\027\031\021\ \030\036\027\027\036\020\024 \f\r\017\013\036\r\024\020\024 \024\021\r\036\ \030)Tj 0 Tc 0 Tw (-)Tj 0.01 Tc 0.06 Tw T* [(\f\021\017\016 )0.5(\023\024)]TJ /Span<>> BDC ( )Tj EMC 3.473 0 Td (\f\030\026\r\027\036\027\017\033 \f)Tj /Span<>> BDC ( )Tj EMC 5.7 0 Td [(\036\020\024 \031\001\017\r\026\027\017\036\n )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC (\023\024\n\024\013\034\033 \024\021)Tj 0 Tc 0 Tw (-)Tj 0.01 Tc 0.003 Tw -9.173 -1.218 Td (\007\036\035\034\027\t\b \001\r\024\r \(\004\026\f\021\024\021\026 \026\ \032\017\r\035\036\027\017\016 54,8%, )Tj /T1_2 1 Tf 0 Tc 0 Tw (\032)Tj /T1_1 1 Tf 0.01 Tc 0.003 Tw /Span<>> BDC 18.708 0 Td ( )Tj EMC (>)Tj /Span<>> BDC ( )Tj EMC [(0,05\).)10( )]TJ 0.686 Tw -18.708 -1.218 Td [(\221\030\026\r\027\017\r\026\016 )0.5(\023\024\035\031\004\036\027\027\t\036 )0.5(\023\024\022\026\026\021\036\035\017 )0.5(\026\032\017\r\035\036\027\017\016)10( )]TJ 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 0 Tc 0.111 Tw 9 0 0 9 42.5197 730.483 Tm (\020\004\206\f\t\204\004 4.)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf ( \213\026\023\023\022\021\026\002 \n\203\031\021\013\026 \f\205\021\013\203\ \025\025 \030\031\032\204\026\021\025\002 \033\n)Tj /Span<>> BDC ( )Tj EMC (\001\013\026\023\031 \026\021\026\023\022\021\n\017 \025\021\013\n\021\024\ \025\021\031\021\203\025\025 Wexner \030\n)Tj /Span<>> BDC ( )Tj EMC (\025)Tj /Span<>> BDC ( )Tj EMC (\033\n\t\023\031 \004\025\032\205\032\202\025\006\031\t\013\n\202\n )Tj 0 Tw 0 -1.2 TD (\023\031\006\031\021\025\002)Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf T* [(T)48(able 4.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf [( W)30.1(e)-15(xner anal incontinence scale q)14.2(uestionnaire before and af)-45.7(ter surg)12(er)-43(y)]TJ ET 0 0 0 1 K 0.5 w /GS2 gs q 1 0 0 1 42.5197 704.381 cm 0 0 m 153.321 0 l S Q q 1 0 0 1 42.7697 683.5618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 195.8405 704.381 cm 0 0 m 85.039 0 l S Q q 1 0 0 1 195.8405 683.5618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 280.8799 704.381 cm 0 0 m 85.039 0 l S Q q 1 0 0 1 280.8799 683.5618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 365.9193 704.381 cm 0 0 m 85.039 0 l S Q q 1 0 0 1 365.9193 683.5618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 450.9586 704.381 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 450.9586 683.5618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 496.313 683.5618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 42.5197 683.3118 cm 0 0 m 153.321 0 l S Q q 1 0 0 1 42.7697 672.1005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 195.8405 683.3118 cm 0 0 m 85.039 0 l S Q q 1 0 0 1 195.8405 672.1005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 280.8799 683.3118 cm 0 0 m 85.039 0 l S Q q 1 0 0 1 280.8799 672.1005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 365.9193 683.3118 cm 0 0 m 85.039 0 l S Q q 1 0 0 1 365.9193 672.1005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 450.9586 683.3118 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 450.9586 672.1005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 672.1005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 671.8505 cm 0 0 m 153.321 0 l S Q q 1 0 0 1 42.7697 660.6393 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 195.8405 671.8505 cm 0 0 m 85.039 0 l S Q q 1 0 0 1 195.8405 660.6393 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 280.8799 671.8505 cm 0 0 m 85.039 0 l S Q q 1 0 0 1 280.8799 660.6393 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 365.9193 671.8505 cm 0 0 m 85.039 0 l S Q q 1 0 0 1 365.9193 660.6393 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 450.9586 671.8505 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 450.9586 660.6393 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 660.6393 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 660.3893 cm 0 0 m 153.321 0 l S Q q 1 0 0 1 195.8405 660.3893 cm 0 0 m 85.039 0 l S Q q 1 0 0 1 280.8799 660.3893 cm 0 0 m 85.039 0 l S Q q 1 0 0 1 365.9193 660.3893 cm 0 0 m 85.039 0 l S Q q 1 0 0 1 450.9586 660.3893 cm 0 0 m 45.604 0 l S Q BT /GS1 gs /T1_4 1 Tf 8 0 0 8 92.6494 690.9465 Tm (\200\r\006\t\002\240 \002\204\r\b\220\t)Tj 15.97 0.6 Td (\035\020)Tj /Span<>> BDC ( )Tj EMC (+)Tj /Span<>> BDC ( )Tj EMC (\200\255\215\200)Tj -0.866 -1.2 Td (Me \(min\231max\))Tj 11.834 1.2 Td (\035\020)Tj /Span<>> BDC ( )Tj EMC (+)Tj /Span<>> BDC ( )Tj EMC (\255\215\035)Tj -1.204 -1.2 Td (Me \(min\231max\))Tj 11.866 1.2 Td (\035\020)Tj /Span<>> BDC ( )Tj EMC (+)Tj /Span<>> BDC ( )Tj EMC (\223\026\017)Tj -1.236 -1.2 Td (Me \(min\231max\))Tj /T1_5 1 Tf 11 0.6 Td (\n)Tj /T1_1 1 Tf -53.244 -2.033 Td (\007\024 \024\023\036\030\026\006\017\017)Tj 22.238 0 Td (1,0)Tj /Span<>> BDC ( )Tj EMC (\(0\2265\))Tj 10.63 0 Td (1,5)Tj /Span<>> BDC ( )Tj EMC (\(0\2266\))Tj 10.63 0 Td (1,0 \(0\2268\))Tj 8.798 0 Td (>)Tj /Span<>> BDC ( )Tj EMC (0,05)Tj -52.295 -1.433 Td (\023\024\f\035\036 \024\023\036\030\026\006\017\017)Tj 22.238 0 Td (1,5)Tj /Span<>> BDC ( )Tj EMC (\(0\2266\))Tj 10.63 0 Td (1,5)Tj /Span<>> BDC ( )Tj EMC (\(0\2267\))Tj 10.63 0 Td (1,5)Tj /Span<>> BDC ( )Tj EMC (\(0\2269\))Tj 8.798 0 Td (>)Tj /Span<>> BDC ( )Tj EMC (0,05)Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 9 0 0 9 42.5197 643.67 Tm (\020\004\206\f\t\204\004 5.)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf ( \n\013\026\016\026\024\031\023\025 \030\026\027\023\031\021\025\002 \027\ )Tj /Span<>> BDC ( )Tj EMC (\026\021\026\023\022\021\n\003 \013\026\021\026\023\031 \030\n)Tj /Span<>> BDC ( )Tj EMC (\025)Tj /Span<>> BDC ( )Tj EMC [(\033\n\t\023\031 \004\025\032\205\032\202)0.5(\025\006\031\t\013\n\202\n \023\031\006\031\021\025\002 \033\n)]TJ /Span<>> BDC ( )Tj EMC (\030\026\021\021\020\003 \t\f\025\021\013\024\031\032\n\003\031\024\032\025\ \025)Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf T* [(T)48(able 5.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf [( Sphincterometr)-42.8(y before and af)-45.9(ter surg)12.1(er)-43(y)]TJ ET /GS2 gs q 1 0 0 1 42.5197 628.368 cm 0 0 m 170.329 0 l S Q q 1 0 0 1 42.7697 616.8987 cm 0 0 m 0 11.219 l S Q q 1 0 0 1 212.8484 628.368 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 212.8484 617.1487 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 255.3681 628.368 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 297.8878 628.368 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 297.8878 617.1487 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 340.4075 628.368 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 382.9272 628.368 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 382.9272 617.1487 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 416.9429 628.368 cm 0 0 m 79.62 0 l S Q q 1 0 0 1 416.9429 616.8987 cm 0 0 m 0 11.219 l S Q q 1 0 0 1 496.313 616.8987 cm 0 0 m 0 11.219 l S Q q 1 0 0 1 42.7697 605.6796 cm 0 0 m 0 11.219 l S Q q 1 0 0 1 212.5984 616.8987 cm 0 0 m 42.77 0 l S Q q 1 0 0 1 212.8484 605.6796 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 255.3681 616.8987 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 255.3681 605.6796 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 297.8878 616.8987 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 297.8878 605.6796 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 340.4075 616.8987 cm 0 0 m 42.77 0 l S Q q 1 0 0 1 340.4075 605.6796 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 382.9272 605.6796 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 416.9429 605.6796 cm 0 0 m 0 11.219 l S Q q 1 0 0 1 496.313 605.6796 cm 0 0 m 0 11.219 l S Q q 1 0 0 1 42.5197 605.4296 cm 0 0 m 170.329 0 l S Q q 1 0 0 1 42.7697 575.0182 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 212.8484 605.4296 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 212.8484 575.0182 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 255.3681 605.4296 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 255.3681 575.0182 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 297.8878 605.4296 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 297.8878 575.0182 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 340.4075 605.4296 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 340.4075 575.0182 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 382.9272 605.4296 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 382.9272 575.0182 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 416.9429 605.4296 cm 0 0 m 79.62 0 l S Q q 1 0 0 1 416.9429 575.0182 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 496.313 575.0182 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 42.5197 574.7682 cm 0 0 m 170.329 0 l S Q q 1 0 0 1 42.7697 544.357 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 212.8484 574.7682 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 212.8484 544.357 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 255.3681 574.7682 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 255.3681 544.357 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 297.8878 574.7682 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 297.8878 544.357 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 340.4075 574.7682 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 340.4075 544.357 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 382.9272 574.7682 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 382.9272 544.357 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 416.9429 574.7682 cm 0 0 m 79.62 0 l S Q q 1 0 0 1 416.9429 544.357 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 496.313 544.357 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 42.5197 544.107 cm 0 0 m 170.329 0 l S Q q 1 0 0 1 212.8484 544.107 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 255.3681 544.107 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 297.8878 544.107 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 340.4075 544.107 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 382.9272 544.107 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 416.9429 544.107 cm 0 0 m 79.62 0 l S Q BT /GS1 gs /T1_4 1 Tf 8 0 0 8 230.4886 619.7333 Tm (\035\020)Tj /Span<>> BDC ( )Tj EMC (+)Tj /Span<>> BDC ( )Tj EMC (\200\255\215\200, Me)Tj 10.968 0 Td (\035\020)Tj /Span<>> BDC ( )Tj EMC (+)Tj /Span<>> BDC ( )Tj EMC (\255\215\035, Me)Tj /T1_5 1 Tf 9.953 -0.716 Td (\n)Tj /T1_4 1 Tf 4.554 0.6 Td (\025\002\006\214\004\f\001\b\013\r )Tj -0.008 Tw -1.814 -1.2 Td (\213\b\004\201\r\b\t\235 \(\214\214 \006\003.)Tj /Span<>> BDC ( )Tj EMC (\217\003.\))Tj 0 Tw -23.765 -0.117 Td (\031\002 )Tj 4.561 0 Td (\200\002\217\f\r)Tj 6.069 0 Td (\031\002)Tj 4.561 0 Td (\200\002\217\f\r)Tj /T1_1 1 Tf -38.198 -1.433 Td (\221\030\036\007\027\036\036 \007\026\r\035\036\027\017\036 \023\024\022\ \024\016 \(\n\n \030\021. \f\021.\):)Tj 1.063 -1.2 Td (\204\031\032\004\017\027\t)Tj T* (\240\036\027\013\017\027\t)Tj 22 1.2 Td (38)Tj T* (36)Tj 5.315 1.2 Td (39)Tj T* (38)Tj 5.315 1.2 Td (37)Tj T* (39)Tj 5.315 1.2 Td (36)Tj T* (38)Tj 4.074 1.2 Td (>)Tj /Span<>> BDC ( )Tj EMC (0,05)Tj 7.018 0 Td (43\22661)Tj T* (41\22663)Tj -50.1 -1.433 Td (\204\026\022\f\017\n\026\035\034\027\024\036 \007\026\r\035\036\027\017\036\ \f\024\022\030\026\013\036\027\017\016 \(\n\n \030\021. \f\021.\))Tj 1.063 -1.2 Td (\204\031\032\004\017\027\t)Tj 0 -1.2 TD (\240\036\027\013\017\027\t)Tj 21.75 1.2 Td (159)Tj T* (139)Tj 5.315 1.2 Td (154)Tj T* (131)Tj 5.315 1.2 Td (148)Tj T* (160)Tj 5.315 1.2 Td (146)Tj T* (146)Tj 4.324 1.2 Td (>)Tj /Span<>> BDC ( )Tj EMC (0,05)Tj 6.518 0 Td (121\226227)Tj T* (110\226178)Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\033\030\031\030\213\b)-20.9(\035\231\213\233\t \021\032)50(\b)42(\032\231\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj /T1_6 1 Tf 25 0 0 25 512.9018 56.0378 Tm (67)Tj ET endstream endobj 1871 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.28 Tw 10 0 0 10 70.8661 298.5999 Tm (\023\036\030\017\024\007\036 \023\024\r\024\035\016\036\021 \024\002\255\ \036\022\021\017\r\027\024, \027\026)Tj /Span<>> BDC ( )Tj EMC (\030\026\027\027\017\b \f\030\024\022\026\b, )Tj 0 Tw 0 -1.218 TD (\022\024\027\f\021\026\021\017\030\024\r\026\021\034 \026\032\017\r\035\ \036\027\017\036 \017\035\017 \030\036\006\017\007\017\r \f\r\017\013\026\ .)Tj 0.02 Tw T* (\200\024 \r\f\036\b \024\f\021\026\035\034\027\t\b \f\035\031\004\026\016\ \b \030\036\006\017\007\017\r\026, \022\024\020\007\026 \026\032\017\r\035\ \036)Tj 0 Tw (-)Tj 0.036 Tw T* (\027\017\016 \f\r\017\013\036\r\024\020\024 \b\024\007\026 \027\036 \024\ \021\n\036\004\026\035\024\f\034, \023\026\006\017\036\027\021\026\n \021\ \026\022\032\036 )Tj 0 Tw T* (\r\t\023\024\035\027\016\035\017\f\034 \r\t\001\036\024\023\017\f\026\027\ \027\t\036 \n\036\021\024\007\017\022\017.)Tj 0.079 Tw T* (\215\024\f\035\036\024\023\036\030\026\006\017\024\027\027\t\005 \022\024\ \005\022\024-\007\036\027\034 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\r\f\036\b \r\026\030\017\026\027\021\026\b )Tj 0.073 Tw T* [(\035\017\022\r\017\007\026\006\017\017 \r\027\031\021\030\036\027\027\036\ \020\024 )0.5(\f\r\017\013\036\r\024\020\024 \024\021\r\036\030\f\021\017\016 \022\024\ \035\036)]TJ 0 Tw (-)Tj 0.007 Tw T* (\002\026\035\f\016 \024\021 1 \007\024)Tj /Span<>> BDC ( )Tj EMC (9 \007\027\036\005 \(\204\036)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (3,5\). \221\021\026\021\017\f\021\017\004\036\f\022\017 \027\026\004\017\ )Tj 0 Tw (-)Tj 0.029 Tw T* (\n\t\b \030\026\035\017\004\017\005 \n\036\032\007\031 \020\030\031\023\ \023\026\n\017 \023\024)Tj /Span<>> BDC ( )Tj EMC (\007\026\027\027\024\n\031 \023\024\022\026\026\021\036)Tj 0 Tw (-)Tj T* (\035\033 \027\036 \r\t\016\r\035\036\027\024 \()Tj /T1_1 1 Tf (\032)Tj /T1_0 1 Tf /Span<>> BDC ( )Tj EMC (>)Tj /Span<>> BDC ( )Tj EMC (0,05\).)Tj 0.059 Tw T* (\221 \006\036\035\034\033 \024\006\036\027\022\017 \r\035\017\016\027\017\ \016 \030\026\035\017\004\027\t\b \235\026\022\021\024\030\024\r \027\026\ )Tj /Span<>> BDC ( )Tj EMC (\004\026)Tj 0 Tw (-)Tj 0.1 Tw T* [(\f\021\024\021\031 )0.5(\026\032\017\r\035\036\027\017\016 )0.5(\f\r\017\013\036\005 \023\030\017)]TJ /Span<>> BDC ( )Tj EMC 13.067 0 Td (\022\026\032\007\024\n \017)Tj /Span<>> BDC ( )Tj EMC 4.758 0 Td (\r\026\030\017\026\027\021\024\r )Tj -0.006 Tw -17.825 -1.218 Td (\026\022\030\t\021\017\016 \r\027\031\021\030\036\027\027\036\020\024 \f\ \r\017\013\036\r\024\020\024 \024\021\r\036\030\f\021\017\016 \002\t\035\ \023\030\024)Tj 0 Tw (-)Tj 0.251 Tw T* (\r\036\007\036\027 \024\007\027\024\235\026\022\021\024\030\027\t\005 \026\ \027\026\035\017. \230\026\022, \r)Tj /Span<>> BDC ( )Tj EMC (\026\027\026\035\017 \002\t\035\017 )Tj 0.106 Tw T* (\r\022\035\033\004\036\027\t \f\035\036\007\031\033\013\017\036 \235\026\ \022\021\024\030\t: \023\024\035, \r\026\030\017\026\027\021 \030\026\f\023\ \024)Tj 0 Tw (-)Tj 0.171 Tw T* (\035\024\032\036\027\017\016 \f\r\017\013\026 \023\024)Tj /Span<>> BDC ( )Tj EMC (\024\021\027\024\001\036\027\017\033 \022)Tj /Span<>> BDC ( )Tj EMC (\026\027\026\035\034\027\024\n\031 \f\235\017\027\022)Tj 0 Tw (-)Tj 0.264 Tw T* (\021\036\030\031, \027\026\035\017\004\017\036/\024\021\f\031\021\f\021\r\ \017\036 \026\021\036\022\024\r, \f\026\n\024\f\021\024\016\021\036\035\ \034\027\024\036 )Tj 0.222 Tw T* (\017\035\017 \b\017\030\031\030\020\017\004\036\f\022\024\036 \r\f\022\030\ \t\021\017\036 \024\f\021\030\024\020\024 \023\026\030\026\023\030\024\022\ \021\017\021\026 )Tj 0.342 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC 1.048 0 Td [(\026\027\026\n\027\036\036, )0.5(\027\026\035\017\004\017\036/\024\021\f\031\021\f\021\r\017\036 )0.5(\023\030\036\007\r\026\030\017\021\036\035\034\027\024\020\024 )]TJ 0.186 Tw 22.196 21.92 Td [(\007\030\036\027\017\030\024\r\026\027\017\016 )0.6(\f\r\017\013\026 )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC 10.194 0 Td [(\023\024\n\024\013\034\033 )0.5(\035\026\021\036\022\f\027\024\005 )0.6(\035\017\020\026\021\031)]TJ 0 Tw (-)Tj 0.052 Tw -10.194 -1.218 Td (\030\t, \007\035\017\027\026 \f\r\017\013\036\r\024\020\024 \b\024\007\026\ , \035\024\022\026\035\017\026\006\017\016 \r\027\031\021\030\036\027\027\ \036\020\024 )Tj 0.163 Tw T* (\f\r\017\013\036\r\024\020\024 \024\021\r\036\030\f\021\017\016 \(\230\026\ \002\035.)Tj /Span<>> BDC ( )Tj EMC (2,3\). \215\030\017)Tj /Span<>> BDC ( )Tj EMC (\026\027\026\035\017\036 \r\035\017)Tj 0 Tw (-)Tj 0.206 Tw T* (\016\027\017\016 \007\026\027\027\t\b \235\026\022\021\024\030\024\r \027\ \026)Tj /Span<>> BDC ( )Tj EMC (\030\036\031\035\034\021\026\021\t \035\036\004\036\027\017\016, \022\026\ \022 )Tj 0.197 Tw T* (\r\027\031\021\030\017 \020\030\031\023\023, \021\026\022 \017)Tj /Span<>> BDC ( )Tj EMC (\n\036\032\007\031 \020\030\031\023\023\026\n\017 \f\021\026\021\017\f\021\ \017\004\036\f\022\017 )Tj 0.035 Tw T* (\027\026\004\017\n\024\020\024 \017\b \r\035\017\016\027\017\016 \r)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\034\001\017\027\f\021\r\036 \f\035\031\004\026\036\r \027\036\ \r\t)Tj 0 Tw (-)Tj 0.067 Tw T* (\016\r\035\036\027\024 \()Tj /T1_1 1 Tf 0 Tw (p)Tj /T1_0 1 Tf 0.067 Tw /Span<>> BDC ( )Tj EMC (>)Tj /Span<>> BDC ( )Tj EMC [(0,05\). )0.5(\210\007\027\026\022\024 \r\027\031\021\030\017 \020\030\031\023\023\t )0.5(\214\230)]TJ /Span<>> BDC ( )Tj EMC (+)Tj /Span<>> BDC ( )Tj EMC (\215\221\204\215, )Tj -0.026 Tw T* (\023\030\017)Tj /Span<>> BDC ( )Tj EMC (\007\017\026\n\036\021\030\036 \r\027\031\021\030\036\027\027\036\020\024\ \f\r\017\013\036\r\024\020\024 \024\021\r\036\030\f\021\017\016, \023\030\ \036)Tj 0 Tw (-)Tj -0.009 Tw T* (\r\t\001\026\033\013\036\n 3)Tj /Span<>> BDC ( )Tj EMC 5.56 0 Td [(\n\n, \030\036\031\035\034\021\026\021\t )0.5(\002\t\035\017 \f\021\026\021\017\f\021\017\004\036\f\022\017 )0.5(\027\026)]TJ 0 Tw (-)Tj 0.011 Tw -5.56 -1.218 Td (\004\017\n\024 \b\031\032\036 \023\024)Tj /Span<>> BDC ( )Tj EMC (\f\030\026\r\027\036\027\017\033 \f)Tj /Span<>> BDC ( )Tj EMC (\021\036\n\017 \f\035\031\004\026\016\n\017, \022\024\020\007\026 \007\017\ \026)Tj 0 Tw (-)Tj 0.099 Tw T* [(\n\036\021\030 \r\027\031\021\030\036\027\027\036\020\024 )0.5(\024\021\r\036\030\f\021\017\016 \002\t\035)]TJ /Span<>> BDC ( )Tj EMC 14.111 0 Td (\252)Tj /Span<>> BDC ( )Tj EMC (3 \n\n \()Tj /T1_1 1 Tf 0 Tw (p)Tj /T1_0 1 Tf 0.099 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,033\). )Tj 0.133 Tw -14.111 -1.218 Td (\222\n\036\030\036\027\017\036 \007\017\026\n\036\021\030\026 \r\027\031\ \021\030\036\027\027\036\020\024 \f\r\017\013\036\r\024\020\024 \024\021\ \r\036\030)Tj 0 Tw (-)Tj 0.214 Tw T* (\f\021\017\016 \023\030\024\017\r\024\007\017\035\024\f\034 \023\030\017\ )Tj /Span<>> BDC ( )Tj EMC (\023\024\n\024\013\017 \224\217\211\003\222. \215\030\017\004\017\027\024\ \005 )Tj -0.006 Tw T* (\002\024\035\036\036 \004\026\f\021\024\020\024 \030\036\006\017\007\017\ \r\026 \f\r\017\013\026 \023\024\f\035\036 \214\230)Tj /Span<>> BDC ( )Tj EMC (+)Tj /Span<>> BDC ( )Tj EMC (\215\221\204\215 \031)Tj /Span<>> BDC ( )Tj EMC (\023\026)Tj 0 Tw (-)Tj 0.278 Tw T* (\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\036\036 \001\017\030\024\022\017\n \007\017\026\n\036\021\030\ \024\n \r\027\031\021\030\036\027\027\036\020\024 )Tj 0.178 Tw T* (\f\r\017\013\036\r\024\020\024 \024\021\r\036\030\f\021\017\016 \007\024\ \f\021\026\021\024\004\027\024 \023\024\027\016\021\027\t. \212\017\026\n\ \036\021\030 )Tj 0.298 Tw T* (\024\021\r\036\030\f\021\017\016 \002\024\035\036\036 3 \n\n \027\036 \023\ \024\r\024\035\016\035 \027\026\007\036\032\027\024 \017\024)Tj 0 Tw (-)Tj 0.256 Tw T* (\035\017\030\024\r\026\021\034 \022\026\027\026\035 \f\r\017\013\026 \024\ \021 \023\030\024\f\r\036\021\026 \023\030\016\n\024\005 \022\017\001\022\ \017, )Tj 0.139 Tw T* (\004\021\024 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\030\026\f\f\026\f\t\r\026\027\017\017 \001\024\r\027\024\020\024 \n\026\ \021\036\030\017\026\035\026, \022\024\021\024\030\t\n )Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf -0.014 Tw 9 0 0 9 70.8661 730.483 Tm (\020\004\206\f\t\204\004 2.)Tj 0 0 0 1 k /GS1 gs /T1_1 1 Tf ( \207\032\026\027\021\025\024\031\023\022\021\020\017 \026\021\026\023\025\ \016 \032\031\016\205\023\022\024\026\024\n\027 \023\031\006\031\021\025\ \002 \027)Tj /Span<>> BDC ( )Tj EMC (\202\032\205\033\033\026\004 \025\t\t\023\031\030\n\027\026\021\025\002 \ \027)Tj /Span<>> BDC ( )Tj EMC (\016\026\027\025\t\025\003\n\t\024\025 \n\024 \032\026\016\023\025\006\021\ \020\004 \f\026\013\024\n\032\n\027 )Tj 0 Tw 0 -1.2 TD (\(n)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (121\))Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf T* [(T)48(able 2)16(.)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf [( Com)16.1(parativ)13(e analysis of treatment results \(n)]TJ /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (121\))Tj ET 0 0 0 1 K 0.5 w /GS2 gs q 1 0 0 1 70.8661 704.381 cm 0 0 m 136.313 0 l S Q q 1 0 0 1 71.1161 692.9117 cm 0 0 m 0 11.219 l S Q q 1 0 0 1 207.1791 704.381 cm 0 0 m 51.024 0 l S Q q 1 0 0 1 207.1791 693.1617 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 258.2028 704.381 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 300.7224 704.381 cm 0 0 m 51.024 0 l S Q q 1 0 0 1 300.7224 693.1617 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 351.746 704.381 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 394.2657 704.381 cm 0 0 m 51.024 0 l S Q q 1 0 0 1 394.2657 693.1617 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 445.2894 704.381 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 487.809 704.381 cm 0 0 m 37.1 0 l S Q q 1 0 0 1 487.809 693.1617 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 524.6594 692.9117 cm 0 0 m 0 11.219 l S Q q 1 0 0 1 71.1161 681.6926 cm 0 0 m 0 11.219 l S Q q 1 0 0 1 206.9291 692.9117 cm 0 0 m 51.274 0 l S Q q 1 0 0 1 207.1791 681.6926 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 258.2028 692.9117 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 258.2028 681.6926 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 300.7224 692.9117 cm 0 0 m 51.024 0 l S Q q 1 0 0 1 300.7224 681.6926 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 351.746 692.9117 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 351.746 681.6926 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 394.2657 692.9117 cm 0 0 m 51.024 0 l S Q q 1 0 0 1 394.2657 681.6926 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 445.2894 692.9117 cm 0 0 m 42.77 0 l S Q q 1 0 0 1 445.2894 681.6926 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 487.809 681.6926 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 524.6594 681.6926 cm 0 0 m 0 11.219 l S Q q 1 0 0 1 70.8661 681.4426 cm 0 0 m 136.313 0 l S Q q 1 0 0 1 71.1161 660.6313 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 207.1791 681.4426 cm 0 0 m 51.024 0 l S Q q 1 0 0 1 207.1791 660.6313 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 258.2028 681.4426 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 258.2028 660.6313 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 300.7224 681.4426 cm 0 0 m 51.024 0 l S Q q 1 0 0 1 300.7224 660.6313 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 351.746 681.4426 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 351.746 660.6313 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 394.2657 681.4426 cm 0 0 m 51.024 0 l S Q q 1 0 0 1 394.2657 660.6313 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 445.2894 681.4426 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 445.2894 660.6313 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 487.809 681.4426 cm 0 0 m 37.1 0 l S Q q 1 0 0 1 487.809 660.6313 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 524.6594 660.6313 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 70.8661 660.3813 cm 0 0 m 136.313 0 l S Q q 1 0 0 1 71.1161 620.37 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 207.1791 660.3813 cm 0 0 m 51.024 0 l S Q q 1 0 0 1 207.1791 620.37 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 258.2028 660.3813 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 258.2028 620.37 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 300.7224 660.3813 cm 0 0 m 51.024 0 l S Q q 1 0 0 1 300.7224 620.37 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 351.746 660.3813 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 351.746 620.37 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 394.2657 660.3813 cm 0 0 m 51.024 0 l S Q q 1 0 0 1 394.2657 620.37 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 445.2894 660.3813 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 445.2894 620.37 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 487.809 660.3813 cm 0 0 m 37.1 0 l S Q q 1 0 0 1 487.809 620.37 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 524.6594 620.37 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 70.8661 620.12 cm 0 0 m 136.313 0 l S Q q 1 0 0 1 71.1161 589.7087 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 207.1791 620.12 cm 0 0 m 51.024 0 l S Q q 1 0 0 1 207.1791 589.7087 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 258.2028 620.12 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 258.2028 589.7087 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 300.7224 620.12 cm 0 0 m 51.024 0 l S Q q 1 0 0 1 300.7224 589.7087 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 351.746 620.12 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 351.746 589.7087 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 394.2657 620.12 cm 0 0 m 51.024 0 l S Q q 1 0 0 1 394.2657 589.7087 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 445.2894 620.12 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 445.2894 589.7087 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 487.809 620.12 cm 0 0 m 37.1 0 l S Q q 1 0 0 1 487.809 589.7087 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 524.6594 589.7087 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 70.8661 589.4587 cm 0 0 m 136.313 0 l S Q q 1 0 0 1 71.1161 559.0474 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 207.1791 589.4587 cm 0 0 m 51.024 0 l S Q q 1 0 0 1 207.1791 559.0474 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 258.2028 589.4587 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 258.2028 559.0474 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 300.7224 589.4587 cm 0 0 m 51.024 0 l S Q q 1 0 0 1 300.7224 559.0474 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 351.746 589.4587 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 351.746 559.0474 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 394.2657 589.4587 cm 0 0 m 51.024 0 l S Q q 1 0 0 1 394.2657 559.0474 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 445.2894 589.4587 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 445.2894 559.0474 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 487.809 589.4587 cm 0 0 m 37.1 0 l S Q q 1 0 0 1 487.809 559.0474 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 524.6594 559.0474 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 70.8661 558.7974 cm 0 0 m 136.313 0 l S Q q 1 0 0 1 71.1161 518.7861 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 207.1791 558.7974 cm 0 0 m 51.024 0 l S Q q 1 0 0 1 207.1791 518.7861 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 258.2028 558.7974 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 258.2028 518.7861 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 300.7224 558.7974 cm 0 0 m 51.024 0 l S Q q 1 0 0 1 300.7224 518.7861 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 351.746 558.7974 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 351.746 518.7861 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 394.2657 558.7974 cm 0 0 m 51.024 0 l S Q q 1 0 0 1 394.2657 518.7861 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 445.2894 558.7974 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 445.2894 518.7861 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 487.809 558.7974 cm 0 0 m 37.1 0 l S Q q 1 0 0 1 487.809 518.7861 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 524.6594 518.7861 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 70.8661 518.5361 cm 0 0 m 136.313 0 l S Q q 1 0 0 1 207.1791 518.5361 cm 0 0 m 51.024 0 l S Q q 1 0 0 1 258.2028 518.5361 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 300.7224 518.5361 cm 0 0 m 51.024 0 l S Q q 1 0 0 1 351.746 518.5361 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 394.2657 518.5361 cm 0 0 m 51.024 0 l S Q q 1 0 0 1 445.2894 518.5361 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 487.809 518.5361 cm 0 0 m 37.1 0 l S Q BT /GS1 gs /T1_2 1 Tf 8 0 0 8 97.3801 690.0118 Tm (\017\204\r\b\t\004\r\214\013\005 \212\004\006\004\214\r\003\006)Tj 15.737 0.717 Td (\035\020)Tj /Span<>> BDC ( )Tj EMC (+)Tj /Span<>> BDC ( )Tj EMC (\200\255\215\200, )Tj /T1_3 1 Tf (n)Tj /T1_2 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (43)Tj 12.031 0 Td (\035\020)Tj /Span<>> BDC ( )Tj EMC (+)Tj /Span<>> BDC ( )Tj EMC (\255\215\035, )Tj /T1_3 1 Tf (n)Tj /T1_2 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (47)Tj 11.725 0 Td (\035\020)Tj /Span<>> BDC ( )Tj EMC (+)Tj /Span<>> BDC ( )Tj EMC (\223\026\017, )Tj /T1_3 1 Tf (n)Tj /T1_2 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (31)Tj /T1_3 1 Tf 11.354 -0.716 Td (\n)Tj /T1_2 1 Tf -36.635 -0.717 Td (\033\004\202\t\f\r\b\t\r)Tj 6.666 0 Td (\022\r\204\t\240\t)Tj 5.027 0 Td (\033\004\202\t\f\r\b\t\r)Tj 6.666 0 Td (\022\r\204\t\240\t)Tj 5.027 0 Td (\033\004\202\t\f\r\b\t\r)Tj 6.666 0 Td (\022\r\204\t\240\t)Tj /T1_0 1 Tf -47.193 -1.433 Td (\217\036\031\035\034\021\026\021\t \035\036\004\036\027\017\016 \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\026\b )Tj T* (\017\f\f\035\036\007\024\r\026\027\017\016, )Tj /T1_1 1 Tf (n)Tj /T1_0 1 Tf ( \(%\))Tj 18.014 0.6 Td (33)Tj /Span<>> BDC ( )Tj EMC (\(76,7\))Tj 5.846 0 Td (10)Tj /Span<>> BDC ( )Tj EMC (\(23,3\))Tj 5.846 0 Td (33)Tj /Span<>> BDC ( )Tj EMC (\(70,2\))Tj 5.846 0 Td (14)Tj /Span<>> BDC ( )Tj EMC (\(29,8\))Tj 5.846 0 Td (17)Tj /Span<>> BDC ( )Tj EMC (\(54,8\))Tj 5.846 0 Td (14)Tj /Span<>> BDC ( )Tj EMC (\(45,2\))Tj 5.697 0 Td (0,129)Tj -52.943 -2.033 Td (\200\026\030\017\026\027\021 \030\026\f\023\024\035\024\032\036\027\017\016\ \f\r\017\013\026:)Tj 1.063 -1.2 Td (\215\024\007\022\024\032\027\026\016)Tj /Span<>> BDC ( )Tj EMC (+)Tj /Span<>> BDC ( )Tj EMC (\023\024\r\036\030\b\027\024\f\021\027\026\016 \023\024\030\006\017\016)Tj T* (\206\035\031\002\024\022\026\016 \023\024\030\006\017\016)Tj T* (\224\022\f\021\030\026\f\235\017\027\022\021\036\030\027\t\005)Tj 16.951 2.4 Td (26)Tj /Span<>> BDC ( )Tj EMC (\(81,3\))Tj 0.25 -1.2 Td (7)Tj /Span<>> BDC ( )Tj EMC (\(63,6\))Tj 1.301 -1.2 Td (\226)Tj 4.545 2.4 Td (6)Tj /Span<>> BDC ( )Tj EMC (\(18,7\))Tj T* (4)Tj /Span<>> BDC ( )Tj EMC (\(36,4\))Tj 1.301 -1.2 Td (\226)Tj 4.295 2.4 Td (17)Tj /Span<>> BDC ( )Tj EMC (\(77,2\))Tj 0.25 -1.2 Td (7)Tj /Span<>> BDC ( )Tj EMC (\(63,6\))Tj T* (9)Tj /Span<>> BDC ( )Tj EMC (\(64,3\))Tj 5.846 2.4 Td (5)Tj /Span<>> BDC ( )Tj EMC (\(22,8\))Tj T* (4)Tj /Span<>> BDC ( )Tj EMC (\(26,4\))Tj T* (5)Tj /Span<>> BDC ( )Tj EMC (\(35,7\))Tj 5.596 2.4 Td (10)Tj /Span<>> BDC ( )Tj EMC (\(76,9\))Tj 0.592 -1.2 Td (4)Tj /Span<>> BDC ( )Tj EMC (\(40\))Tj -0.343 -1.2 Td (3)Tj /Span<>> BDC ( )Tj EMC (\(37,5\))Tj 5.846 2.4 Td (3)Tj /Span<>> BDC ( )Tj EMC (\(23,1\))Tj 0.343 -1.2 Td (6)Tj /Span<>> BDC ( )Tj EMC (\(60\))Tj -0.343 -1.2 Td (5)Tj /Span<>> BDC ( )Tj EMC (\(62,5\))Tj 5.447 2.4 Td (0,821)Tj T* (0,459)Tj 0.842 -1.2 Td (1)Tj -53.785 -1.433 Td (\203\026\035\017\004\017\036/\024\021\f\031\021\f\021\r\017\036 \026\021\ \036\022\024\r:)Tj 1.063 -1.2 Td (\207\036 \026\021\036\022\024\r)Tj 0 -1.2 TD (\221 \026\021\036\022\026\n\017)Tj 18.28 1.2 Td (21)Tj T* (12)Tj 6.096 1.2 Td (5)Tj T* (5)Tj 5.596 1.2 Td (12)Tj T* (21)Tj 6.096 1.2 Td (8)Tj T* (6)Tj 5.596 1.2 Td (10)Tj 0.25 -1.2 Td (9)Tj 5.846 1.2 Td (9)Tj T* (3)Tj 4.118 1.2 Td (0,113)Tj T* (0,867)Tj -52.943 -1.433 Td (\200\f\022\030\t\021\017\036 \023\026\030\026\023\030\024\022\021\017\021\ \026:)Tj 1.063 -1.2 Td (\221\026\n\024\023\030\024\017\r\024\035\034\027\024)Tj 0 -1.2 TD (\216\017\030\031\030\020\017\004\036\f\022\017)Tj 18.53 1.2 Td (8)Tj -0.25 -1.2 Td (25)Tj 6.096 1.2 Td (2)Tj T* (8)Tj 5.596 1.2 Td (10)Tj T* (24)Tj 6.096 1.2 Td (5)Tj T* (9)Tj 5.596 1.2 Td (11)Tj 0.25 -1.2 Td (9)Tj 5.846 1.2 Td (4)Tj T* (7)Tj 4.118 1.2 Td (0,763)Tj T* (0,353)Tj -52.943 -1.433 Td (\215\030\036\007\r\026\030\017\021\036\035\034\027\024\036 \007\030\036\027\ \017\030\024\r\026\027\017\036 )Tj 0 -1.2 TD (\035\026\021\036\022\f\027\024\005 \035\017\020\026\021\031\030\024\005:\ )Tj 1.063 -1.2 Td (\212\026)Tj T* (\203\036\021)Tj 17.293 1.2 Td (4)Tj /Span<>> BDC ( )Tj EMC (\(100\))Tj -0.343 -1.2 Td (29)Tj /Span<>> BDC ( )Tj EMC (\(74,3\))Tj 6.689 1.2 Td (0)Tj /Span<>> BDC ( )Tj EMC (\(0\))Tj -0.842 -1.2 Td (10)Tj /Span<>> BDC ( )Tj EMC (\(25,7\))Tj 5.846 1.2 Td (11)Tj /Span<>> BDC ( )Tj EMC (\(68,7\))Tj T* (22)Tj /Span<>> BDC ( )Tj EMC (\(70,9\))Tj 6.096 1.2 Td (5)Tj /Span<>> BDC ( )Tj EMC (\(31,3\))Tj T* (9)Tj /Span<>> BDC ( )Tj EMC (\(29,1\))Tj 6.189 1.2 Td (9)Tj /Span<>> BDC ( )Tj EMC (\(60\))Tj T* (8)Tj /Span<>> BDC ( )Tj EMC (\(50\))Tj 5.846 1.2 Td (6)Tj /Span<>> BDC ( )Tj EMC (\(40\))Tj T* (8)Tj /Span<>> BDC ( )Tj EMC (\(50\))Tj 5.105 1.2 Td (0,310)Tj T* (0,197)Tj /T1_1 1 Tf 7 0 0 7 70.8661 507.0515 Tm (\032\025\003\031\006\026\021\025\031: \032\026\t\006\031\024 \027\020\033\ \n\023\021\031\021 \t)Tj /Span<>> BDC ( )Tj EMC (\033\n\003\n\211\022\007 \013\032\025\024\031\032\025\002 \225\025\001\031\ \032\026)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf -0.03 Tw 9 0 0 9 70.8661 487.7476 Tm [(\020\004\206\f\t\204\004 )0.6(3.)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf [( )0.5(\224\026\t\024\n\024\026 )0.6(\016\026\204\025\027\023\031\021\025\002 )0.7(\t\027\025\211\031\017 )0.6(\033\032\002\003\n\017 )0.5(\013\025\001\013\025 )0.6(\027)]TJ /Span<>> BDC ( )Tj EMC 23.866 0 Td [(\202\032\205\033\033\026\004 )0.6(\025\t\t\023\031\030\n\027\026\021\025\002 )0.5(\027)]TJ /Span<>> BDC ( )Tj EMC 9.867 0 Td [(\016\026\027\025\t\025\003\n\t\024\025 )0.6(\n\024 )0.5(\032\026\016\023\025\006\021\020\004 )0.5(\033\026\032\026\003\031\024\032\n\027)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0 Tw -33.734 -1.2 Td [(T)48(able 3.)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf [( F)27.1(req)14(uency of anal \233stula healing)]TJ ET /GS2 gs q 1 0 0 1 70.8661 472.4456 cm 0 0 m 181.667 0 l S Q q 1 0 0 1 71.1161 432.4264 cm 0 0 m 0 39.769 l S Q q 1 0 0 1 252.5334 472.4456 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 252.5334 432.4264 cm 0 0 m 0 39.769 l S Q q 1 0 0 1 312.061 472.4456 cm 0 0 m 31.181 0 l S Q q 1 0 0 1 312.061 432.4264 cm 0 0 m 0 39.769 l S Q q 1 0 0 1 343.2421 472.4456 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 343.2421 432.4264 cm 0 0 m 0 39.769 l S Q q 1 0 0 1 402.7697 472.4456 cm 0 0 m 31.181 0 l S Q q 1 0 0 1 402.7697 432.4264 cm 0 0 m 0 39.769 l S Q q 1 0 0 1 433.9508 472.4456 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 433.9508 432.4264 cm 0 0 m 0 39.769 l S Q q 1 0 0 1 493.4783 472.4456 cm 0 0 m 31.431 0 l S Q q 1 0 0 1 493.4783 432.4264 cm 0 0 m 0 39.769 l S Q q 1 0 0 1 524.6594 432.4264 cm 0 0 m 0 39.769 l S Q q 1 0 0 1 70.8661 432.1764 cm 0 0 m 181.667 0 l S Q q 1 0 0 1 71.1161 420.9651 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 252.5334 432.1764 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 252.5334 420.9651 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 312.061 432.1764 cm 0 0 m 31.181 0 l S Q q 1 0 0 1 312.061 420.9651 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 343.2421 432.1764 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 343.2421 420.9651 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 402.7697 432.1764 cm 0 0 m 31.181 0 l S Q q 1 0 0 1 402.7697 420.9651 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 433.9508 432.1764 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 433.9508 420.9651 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 493.4783 432.1764 cm 0 0 m 31.431 0 l S Q q 1 0 0 1 493.4783 420.9651 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 420.7151 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 70.8661 420.7151 cm 0 0 m 181.667 0 l S Q q 1 0 0 1 71.1161 409.5038 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 252.5334 420.7151 cm 0 0 m 59.778 0 l S Q q 1 0 0 1 252.5334 409.5038 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 312.061 409.5038 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 342.9921 420.7151 cm 0 0 m 60.028 0 l S Q q 1 0 0 1 343.2421 409.5038 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 402.7697 409.5038 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 433.7008 420.7151 cm 0 0 m 60.028 0 l S Q q 1 0 0 1 433.9508 409.5038 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 493.4783 409.5038 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 409.5038 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 70.8661 409.2538 cm 0 0 m 181.667 0 l S Q q 1 0 0 1 71.1161 398.0425 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 252.5334 409.2538 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 252.5334 398.0425 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 312.061 409.2538 cm 0 0 m 31.181 0 l S Q q 1 0 0 1 312.061 398.0425 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 343.2421 409.2538 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 343.2421 398.0425 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 402.7697 409.2538 cm 0 0 m 31.181 0 l S Q q 1 0 0 1 402.7697 398.0425 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 433.9508 409.2538 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 433.9508 398.0425 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 493.4783 409.2538 cm 0 0 m 31.431 0 l S Q q 1 0 0 1 493.4783 398.0425 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 397.7925 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 70.8661 397.7925 cm 0 0 m 181.667 0 l S Q q 1 0 0 1 71.1161 386.5812 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 252.5334 397.7925 cm 0 0 m 59.778 0 l S Q q 1 0 0 1 252.5334 386.5812 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 312.061 386.5812 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 342.9921 397.7925 cm 0 0 m 60.028 0 l S Q q 1 0 0 1 343.2421 386.5812 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 402.7697 386.5812 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 433.7008 397.7925 cm 0 0 m 60.028 0 l S Q q 1 0 0 1 433.9508 386.5812 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 493.4783 386.5812 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 386.5812 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 70.8661 386.3312 cm 0 0 m 181.667 0 l S Q q 1 0 0 1 71.1161 375.1199 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 252.5334 386.3312 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 252.5334 375.1199 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 312.061 386.3312 cm 0 0 m 31.181 0 l S Q q 1 0 0 1 312.061 375.1199 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 343.2421 386.3312 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 343.2421 375.1199 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 402.7697 386.3312 cm 0 0 m 31.181 0 l S Q q 1 0 0 1 402.7697 375.1199 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 433.9508 386.3312 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 433.9508 375.1199 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 493.4783 386.3312 cm 0 0 m 31.431 0 l S Q q 1 0 0 1 493.4783 375.1199 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 374.8699 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 70.8661 374.8699 cm 0 0 m 181.667 0 l S Q q 1 0 0 1 71.1161 363.6587 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 252.5334 374.8699 cm 0 0 m 59.778 0 l S Q q 1 0 0 1 252.5334 363.6587 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 312.061 363.6587 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 342.9921 374.8699 cm 0 0 m 60.028 0 l S Q q 1 0 0 1 343.2421 363.6587 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 402.7697 363.6587 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 433.7008 374.8699 cm 0 0 m 60.028 0 l S Q q 1 0 0 1 433.9508 363.6587 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 493.4783 363.6587 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 363.6587 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 70.8661 363.4087 cm 0 0 m 181.667 0 l S Q q 1 0 0 1 71.1161 352.1974 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 252.5334 363.4087 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 252.5334 352.1974 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 312.061 363.4087 cm 0 0 m 31.181 0 l S Q q 1 0 0 1 312.061 352.1974 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 343.2421 363.4087 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 343.2421 352.1974 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 402.7697 363.4087 cm 0 0 m 31.181 0 l S Q q 1 0 0 1 402.7697 352.1974 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 433.9508 363.4087 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 433.9508 352.1974 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 493.4783 363.4087 cm 0 0 m 31.431 0 l S Q q 1 0 0 1 493.4783 352.1974 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 351.9474 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 70.8661 351.9474 cm 0 0 m 181.667 0 l S Q q 1 0 0 1 71.1161 340.7361 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 252.5334 351.9474 cm 0 0 m 59.778 0 l S Q q 1 0 0 1 252.5334 340.7361 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 312.061 340.7361 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 342.9921 351.9474 cm 0 0 m 60.028 0 l S Q q 1 0 0 1 343.2421 340.7361 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 402.7697 340.7361 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 433.7008 351.9474 cm 0 0 m 60.028 0 l S Q q 1 0 0 1 433.9508 340.7361 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 493.4783 340.7361 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 340.4861 cm 0 0 m 0 11.461 l S Q q 1 0 0 1 70.8661 340.4861 cm 0 0 m 181.667 0 l S Q q 1 0 0 1 71.1161 329.2748 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 252.5334 340.4861 cm 0 0 m 59.778 0 l S Q q 1 0 0 1 252.5334 329.2748 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 312.061 329.2748 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 342.9921 340.4861 cm 0 0 m 60.028 0 l S Q q 1 0 0 1 343.2421 329.2748 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 402.7697 329.2748 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 433.7008 340.4861 cm 0 0 m 60.028 0 l S Q q 1 0 0 1 433.9508 329.2748 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 493.4783 329.2748 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 329.2748 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 70.8661 329.0248 cm 0 0 m 181.667 0 l S Q q 1 0 0 1 252.5334 329.0248 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 312.061 329.0248 cm 0 0 m 31.181 0 l S Q q 1 0 0 1 343.2421 329.0248 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 402.7697 329.0248 cm 0 0 m 31.181 0 l S Q q 1 0 0 1 433.9508 329.0248 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 493.4783 329.0248 cm 0 0 m 31.431 0 l S Q BT /GS1 gs /T1_2 1 Tf 8 0 0 8 117.3813 449.411 Tm (\017\204\r\b\t\004\r\214\013\r \212\004\006\004\214\r\003\006\013)Tj 18.948 1.8 Td (\030\004\217\003\002\003\004 )Tj -1.006 -1.2 Td (\213\004\202\t\f\r\b\t\235)Tj 0.281 -1.2 Td (\035\020)Tj /Span<>> BDC ( )Tj EMC (+)Tj /Span<>> BDC ( )Tj EMC (\200\255\215\200,)Tj /T1_3 1 Tf 1.066 -1.2 Td (n)Tj /T1_2 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (43)Tj /T1_3 1 Tf 6.736 1.8 Td (\n)Tj /T1_2 1 Tf 4.262 1.8 Td (\030\004\217\003\002\003\004 )Tj -1.006 -1.2 Td (\213\004\202\t\f\r\b\t\235)Tj 0.768 -1.2 Td (\035\020)Tj /Span<>> BDC ( )Tj EMC (+)Tj /Span<>> BDC ( )Tj EMC (\255\215\035)Tj /T1_3 1 Tf 0.579 -1.2 Td (n)Tj /T1_2 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (47)Tj /T1_3 1 Tf 6.736 1.8 Td (\n)Tj /T1_2 1 Tf 4.262 1.8 Td (\030\004\217\003\002\003\004 )Tj -1.006 -1.2 Td (\213\004\202\t\f\r\b\t\235)Tj 0.652 -1.2 Td (\035\020)Tj /Span<>> BDC ( )Tj EMC (+)Tj /Span<>> BDC ( )Tj EMC (\223\026\017,)Tj /T1_3 1 Tf 0.695 -1.2 Td (n)Tj /T1_2 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (31)Tj /T1_3 1 Tf 6.736 1.8 Td (\n)Tj /T1_0 1 Tf -54.13 -3.233 Td (\204\031\032\004\017\027\t)Tj 24.822 0 Td (25/29)Tj 5.798 0 Td (0,054)Tj 5.54 0 Td (22/34)Tj 5.798 0 Td (0,288)Tj 5.54 0 Td (12/19)Tj 5.798 0 Td (0,288)Tj -53.297 -1.433 Td (\240\036\027\013\017\027\t)Tj 25.072 0 Td (8/14)Tj 11.089 0 Td (11/13)Tj 11.589 0 Td (5/12)Tj -47.749 -1.433 Td (\212\035\017\027\026 \b\024\007\026)Tj /Span<>> BDC ( )Tj EMC (>)Tj /Span<>> BDC ( )Tj EMC (30 \n\n)Tj 24.822 0 Td (23/30)Tj 6.298 0 Td (1,0)Tj 5.04 0 Td (19/31)Tj 5.798 0 Td (0,094)Tj 5.79 0 Td (7/16)Tj 5.548 0 Td (0,285)Tj -53.297 -1.433 Td (\212\035\017\027\026 \b\024\007\026)Tj /Span<>> BDC ( )Tj EMC (\252)Tj /Span<>> BDC ( )Tj EMC (30 \n\n)Tj 24.822 0 Td (10/13)Tj 11.339 0 Td (14/16)Tj 11.339 0 Td (10/15)Tj -47.499 -1.433 Td (\212\017\026\n\036\021\030 \r.\f.\024.)Tj /Span<>> BDC ( )Tj EMC (\252)Tj /Span<>> BDC ( )Tj EMC (3,0 \n\n)Tj 24.822 0 Td (28/34)Tj 5.798 0 Td (0,033)Tj 5.54 0 Td (22/30)Tj 5.798 0 Td (0,740)Tj 5.79 0 Td (8/13)Tj 5.548 0 Td (0,716)Tj -53.297 -1.433 Td (\212\017\026\n\036\021\030 \r.\f.\024. 3,1\2265,0 \n\n)Tj 25.322 0 Td (4/9)Tj 10.839 0 Td (11/17)Tj 11.589 0 Td (9/18)Tj -47.749 -1.433 Td (\214\024\022\026\035\017\026\006\017\016 \r.\f.\024. \023\024)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\036\007\027\036\005 \023\024\035\031\024\022\030\031\032\027\ \024\f\021\017)Tj 24.822 0 Td (13/19)Tj 5.798 0 Td (0,116)Tj 5.54 0 Td (14/20)Tj 5.798 0 Td (0,704)Tj 5.79 0 Td (6/14)Tj 5.548 0 Td (0,366)Tj -53.297 -1.433 Td (\214\024\022\026\035\017\026\006\017\016 \r.\f.\024. \023\024)Tj /Span<>> BDC ( )Tj EMC (\026\007\027\036\005 \023\024\035\031\024\022\030\031\032\027\024\f\021\ \017)Tj 24.822 0 Td (18/20)Tj 11.339 0 Td (17/22)Tj 11.339 0 Td (10/16)Tj -47.499 -1.433 Td (\214\024\022\026\035\017\026\006\017\016 \r.\f.\024. \023\024)Tj /Span<>> BDC ( )Tj EMC (\002\024\022\024\r\024\005 \023\024\035\031\024\022\030\031\032\027\024\f\ \021\017)Tj 25.322 0 Td (2/4)Tj 11.339 0 Td (3/5)Tj 11.339 0 Td (1/1)Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\033\030\031\030\213\b)-20.9(\035\231\213\233\t \021\032)50(\b)42(\032\231\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj -51.938 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 23, \023\0221)69(, 202)69(4)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 23, \023\0221)69(, 202)69(4)]TJ /T1_5 1 Tf 25 0 0 25 28.1274 56.0378 Tm (66)Tj ET endstream endobj 1834 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1835 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1836 0 obj <>/Font<>/ProcSet[/PDF/Text/ImageB/ImageC]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1837 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1838 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1932 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\034\205\026\220\007\016\026\001\220\203 \025\221\020\026 \221\002\220\024\ \016\001\016\001\220\205 \024\016\026)11.1(\025\201\013 \007\013\222\016\002\001\025\203 \n)10(\025\013\202)-20(\215\007\205\227\220\220 )]TJ 0 -1 TD [(\221\002\220\022\007\016\017\016\001\220\220 \026\002\013\001\006- \220\022\ \232\n\006)-10(\026\002\013\006\225\220\001\n)-9.9(\026)11(\016\002\001\020\207 \006\r\220\224\016\203 \221\002\205\024\025\203 \n\220\ \n\220)]TJ 37.587 1 Td [(Fiv)12(e)-52(-y)10(ear e)21(xperience of laser coagulation in th)11(e tr)31(eatment )]TJ 6.214 -1 Td [(of tr)21.1(ans- and supr)21.1(asphincteric anal f)-20.9(istulas)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf -0.003 Tw 10 0 0 10 42.5197 408.2019 Tm (\027\026\030\031\032\027\024\020\024 \f\r\017\013\036\r\024\020\024 \024\ \021\r\036\030\f\021\017\016, \004\021\024 \023\030\017\r\024\007\017\035\ \024 \022)Tj /Span<>> BDC ( )Tj EMC (\026)Tj 0 Tw (-)Tj -0.041 Tw 0 -1.218 TD [(\021\030\031\007\027\036\027\017\033 )0.6(\024\021\021\024\022\026 )0.5(\220\022\f\f\031\007\026\021\026 )0.6(\023\024)]TJ /Span<>> BDC ( )Tj EMC 12.98 0 Td [(\022\026\027\026\035\031 )0.5(\f\r\017\013\026 )0.6(\f)]TJ /Span<>> BDC ( )Tj EMC 6.398 0 Td (\023\024\f\035\036)Tj 0 Tw (-)Tj 0.181 Tw -19.378 -1.218 Td (\007\031\033\013\017\n \024\002\024\f\021\030\036\027\017\036\n \020\027\ \024\005\027\024-\r\024\f\023\026\035\017\021\036\035\034\027\024\020\024\ \023\030\024)Tj 0 Tw (-)Tj 0.192 Tw T* (\006\036\f\f\026 \r)Tj /Span<>> BDC ( )Tj EMC (\023\026\030\026\030\036\022\021\026\035\034\027\024\005 \022\035\036\021\ \004\026\021\022\036. \215\024\f\035\036 \030\026\r\017\021\017\016 )Tj -0.021 Tw T* (\007\026\027\027\t\b \024\f\035\024\032\027\036\027\017\005 \r\f\036\n \023\ \026\006\017\036\027\021\026\n, \023\036\030\036\027\036\f\001\017\n \035\ \026)Tj 0 Tw (-)Tj -0.005 Tw T* (\036\030\027\031\033 \022\024\026\020\031\035\016\006\017\033, \f)Tj /Span<>> BDC ( )Tj EMC (\006\036\035\034\033 \026\007\036\022\r\026\021\027\024\020\024 \007\030\ \036\027\017\030\024\r\026)Tj 0 Tw (-)Tj 0.007 Tw T* [(\027\017\016 )0.5(\023\030\024\017\r\024\007\017\035\024\f\034 )0.6(\002\024\035\036\036 )0.5(\001\017\030\024\022\024\036 )0.5(\017\f\f\036\004\036\027\017\036 )0.5(\021\022\026\027\036\005 )]TJ -0.049 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\024\002\035\026\f\021\017 \027\026\030\031\032\027\024\020\024 \f\r\017\ \013\036\r\024\020\024 \024\021\r\036\030\f\021\017\016 \027\026)Tj /Span<>> BDC ( )Tj EMC (\020\035\031\002\017\027\031 )Tj 0.074 Tw T* (\007\024)Tj /Span<>> BDC ( )Tj EMC (1,5\2262,0 \f\n. \200)Tj /Span<>> BDC ( )Tj EMC [(\007\026\035\034\027\036\005\001\036\n \030\026\r\017\021\017\016 )0.5(\023\024\007\024\002\027\t\b \024\f)]TJ 0 Tw (-)Tj -0.035 Tw T* (\035\024\032\027\036\027\017\005 \027\036 \024\021\n\036\004\026\035\024\ \f\034. \221\035\036\007\031\036\021 \024\021\n\036\021\017\021\034, \004\ \021\024 \f\030\036\007\017 )Tj 0.098 Tw T* (\023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\023\024\035\024\032\017\021\036\035\034\027\t\n \017\f\b\024\007\024\n,\ \r)Tj /Span<>> BDC ( )Tj EMC (3/35 \(8,6%\) )Tj 0.022 Tw T* (\f\035\031\004\026\016\b \023\024)Tj /Span<>> BDC ( )Tj EMC (\007\026\027\027\t\n \224\217\211\003\222, \004\036\030\036 2 \n\036\f\016\ \006\026 \023\024\f\035\036 \024\023\036)Tj 0 Tw (-)Tj 0.14 Tw T* (\030\026\006\017\017, \002\t\035\017 \r\t\016\r\035\036\027\t \211\003-\023\ \030\017\027\026\022\017 \024\f\021\026\021\024\004\027\024\005, \004\026\ )Tj 0 Tw (-)Tj 0.279 Tw T* [(\f\021\017\004\027\024 )0.6(\024\002\035\017\021\036\030\017\030\024\r\026\027\027\024\005 )0.6(\f\r\017\013\036\023\024\007\024\002\027\024\005 )0.5(\023\024\035\024\f\021\017 )]TJ 0.15 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\007\017\f\021\026\035\034\027\024\005 \004\026\f\021\017 \026\027\026\035\ \034\027\024\020\024 \022\026\027\026\035\026. \025\035\017\027\017\004\036\ \f\022\026\016 )Tj 0.404 Tw T* (\f\017\n\023\021\024\n\026\021\017\022\026 \031)Tj /Span<>> BDC ( )Tj EMC (\007\026\027\027\t\b \023\026\006\017\036\027\021\024\r \024\021\f\031\021\ \f\021\r\024\r\026\035\026, )Tj -0.045 Tw T* (\002\t\035\024 \024\021\n\036\004\036\027\024 \026\032\017\r\035\036\027\ \017\036 \022\026\022 \r\027\031\021\030\036\027\027\036\020\024, \021\026\ \022 \017)Tj /Span<>> BDC ( )Tj EMC (\027\026)Tj 0 Tw (-)Tj 0.132 Tw T* [(\030\031\032\027\024\020\024 )0.5(\f\r\017\013\036\r\t\b )0.5(\024\021\r\036\030\f\021\017\005. )0.6(\210\007\027\026\022\024 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 17.347 0 Td [(2-\b )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 2.97 0 Td (\021\030\036\b )Tj -0.03 Tw -20.317 -1.218 Td (\f\035\031\004\026\036\r \r)Tj /Span<>> BDC ( )Tj EMC (\021\036\004\036\027\017\036 \023\036\030\017\024\007\026 \007\024)Tj /Span<>> BDC ( )Tj EMC (6)Tj /Span<>> BDC ( )Tj EMC (\n\036\f\016\006\036\r \023\024\f\035\036 \024\023\036\030\026)Tj 0 Tw (-)Tj 0.104 Tw T* (\021\017\r\027\024\020\024 \r\n\036\001\026\021\036\035\034\f\021\r\026 \ \023\030\024\017\024\001\035\024 \024\021\022\030\t\021\017\036 \027\026\ \030\031\032)Tj 0 Tw (-)Tj 0.047 Tw T* [(\027\024\020\024 )0.5(\f\r\017\013\036\r\024\020\024 )0.6(\024\021\r\036\030\f\021\017\016, )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 12.249 0 Td [(\022\024\027\f\021\026\021\017\030\024\r\026\027 )0.6(\030\036\006\017\007\017\r )]TJ 0.146 Tw -12.249 -1.218 Td [(\f\r\017\013\026. )0.5(\200)]TJ /Span<>> BDC ( )Tj EMC 4.168 0 Td [(3-\036\n )0.5(\f\035\031\004\026\036 )0.5(\023\026\006\017\036\027\021 )0.5(\027\026\b\024\007\017\021\f\016 )0.6(\023\024\007 )0.5(\007\017\027\026)]TJ 0 Tw (-)Tj 0.015 Tw -4.168 -1.218 Td (\n\017\004\036\f\022\017\n \027\026\002\035\033\007\036\027\017\036\n. \211\ )Tj /Span<>> BDC ( )Tj EMC (\r\f\036\b \024\f\021\026\035\034\027\t\b \023\026\006\017\036\027\021\024\ \r )Tj 0.049 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC [(\023\024\035\024\032\017\021\036\035\034\027\t\n )0.5(\017\f\b\024\007\024\n )0.5(\024\023\036\030\026\006\017\017, \023\024)]TJ /Span<>> BDC ( )Tj EMC 17.085 0 Td [(\007\026\027\027\t\n )0.5(\211\003\222 )]TJ 0.27 Tw -17.085 -1.218 Td (\n\024\027\017\021\024\030\017\027\020\026, \024\f\021\026\021\024\004\027\ \t\b \f\r\017\013\036\r\t\b \b\024\007\024\r \017)Tj /Span<>> BDC ( )Tj EMC (\023\024\035\024)Tj 0 Tw (-)Tj 0.102 Tw T* (\f\021\036\005 \r\t\016\r\035\036\027\024 \027\036 \002\t\035\024, \021\022\ \026\027\017 \r)Tj /Span<>> BDC ( )Tj EMC (\024\027\036 \030\026\f\023\024\035\024\032\036\027\017\016 )Tj 0.116 Tw T* (\f\r\017\013\036\005 \017\n\036\035\017 \024\007\027\024\030\024\007\027\ \031\033, \f\n\036\001\026\027\027\031\033 \220\b\024\020\036\027\027\024\ \f\021\034 )Tj 0.142 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC [(\r\017\031\026\035\034\027\024 )0.5(\023\030\036\007\f\021\026\r\035\016\035\017 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC [(\f\036\002\016 )0.5(\030\031\002\006\024\r\031\033 \021\022\026\027\034. )]TJ 0.065 Tw 23.244 32.881 Td (\215\026\006\017\036\027\021\026\n \f)Tj /Span<>> BDC ( )Tj EMC (\030\036\006\017\007\017\r\024\n \f\r\017\013\026 \r)Tj /Span<>> BDC ( )Tj EMC (\023\024\f\035\036\007\031\033\013\036\n \002\t\035\024 )Tj 0.197 Tw T* (\r\t\023\024\035\027\036\027\024 \036\020\024 \017\f\f\036\004\036\027\017\ \036 \f)Tj /Span<>> BDC ( )Tj EMC (\031\001\017\r\026\027\017\036\n \f\235\017\027\022\021\036\030\026. )Tj 0.318 Tw T* (\230\026\022\017\n \024\002\030\026\024\n, \r)Tj /Span<>> BDC ( )Tj EMC (\024\021\007\026\035\036\027\027\024\n \023\024\f\035\036\024\023\036\030\ \026\006\017\024\027\027\024\n )Tj 0.249 Tw T* (\023\036\030\017\024\007\036 \023\024\f\035\036 \035\026\036\030\027\024\ \005 \022\024\026\020\031\035\016\006\017\017 \f\r\017\013\026 \f)Tj /Span<>> BDC ( )Tj EMC (\023\035\026)Tj 0 Tw (-)Tj 0.159 Tw T* (\f\021\017\022\024\005 \r\027\031\021\030\036\027\027\036\020\024 \f\r\017\ \013\036\r\024\020\024 \024\021\r\036\030\f\021\017\016 \f\035\017\017\f\ \021\024-)Tj 0.143 Tw T* (\n\t\001\036\004\027\t\n \035\024\f\022\031\021\024\n \b\024\030\024\001\ \017\005 \030\036\031\035\034\021\026\021 \f\024\b\030\026\027\016\035\f\ \016 )Tj 0 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (70,2% \(33/47\) \027\026\002\035\033\007\036\027\017\016\b.)Tj 0.012 Tw T* (\200 \020\030\031\023\023\036 \035\026\036\030\027\024\005 \022\024\026\ \020\031\035\016\006\017\017 \f)Tj /Span<>> BDC ( )Tj EMC (\031\001\017\r\026\027\017\036\n \r\027\031\021\030\036\027)Tj 0 Tw (-)Tj 0.174 Tw T* (\027\036\020\024 \024\021\r\036\030\f\021\017\016 \(\214\230)Tj /Span<>> BDC ( )Tj EMC (+)Tj /Span<>> BDC ( )Tj EMC (\211\200\210\) \026\032\017\r\035\036\027\017\036 \f\r\017\013\026 \023\ \030\024)Tj 0 Tw (-)Tj 0.02 Tw T* (\017\024\001\035\024 \031)Tj /Span<>> BDC ( )Tj EMC (17/31 \(54,8%\) \023\026\006\017\036\027\021\024\r. \222)Tj /Span<>> BDC ( )Tj EMC (11 \023\026\006\017\036\027\021\024\r, )Tj 0.089 Tw T* (\031)Tj /Span<>> BDC ( )Tj EMC (\022\024\021\024\030\t\b \026\032\017\r\035\036\027\017\016 \f\r\017\013\ \036\r\024\020\024 \b\024\007\026 \027\036 \024\021\n\036\004\036\027\024\ , )Tj 0.246 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (4 \f\035\031\004\026\016\b \017\027\026\004\026\035\034\027\024 \002\t\035\ \026 \026\235\017\022\f\017\030\024\r\026\027\026 \220\023\017)Tj 0 Tw (-)Tj 0.207 Tw T* (\021\036\035\017\026\006\017\016 \027\026\030\031\032\027\024\020\024 \f\ \r\017\013\036\r\024\020\024 \024\021\r\036\030\f\021\017\016, \024\007\027\ \026\022\024 )Tj 0.007 Tw T* (\023\030\017)Tj /Span<>> BDC ( )Tj EMC (\r\t\023\024\035\027\036\027\017\017 \022\024\027\021\030\024\035\034\027\ \024\020\024 \224\217\211\003\222 \002\t\035\024 \r\t\016\r\035\036\027\024\ )Tj 0.028 Tw T* (\f\024\b\030\026\027\036\027\017\036 \r\027\031\021\030\036\027\027\036\020\ \024 \f\r\017\013\036\r\024\020\024 \024\021\r\036\030\f\021\017\016 \017\ )Tj /Span<>> BDC ( )Tj EMC (\f\r\017)Tj 0 Tw (-)Tj 0.105 Tw T* (\013\036\r\024\020\024 \b\024\007\026, \017\007\031\013\036\020\024 \r)Tj /Span<>> BDC ( )Tj EMC (\n\t\001\036\004\027\024\005 \021\022\026\027\017 \f\235\017\027\022\021\ \036\030\026 )Tj -0.033 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC 0.717 0 Td [(\024\022\026\027\004\017\r\026\033\013\036\020\024\f\016 )0.6(\f\035\036\023\024 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 10.91 0 Td [(\023\024\007\022\024\032\027\024-\032\017\030\024\r\024\005 )0.6(\022\035\036\021)]TJ 0 Tw (-)Tj -0.009 Tw -11.628 -1.218 Td (\004\026\021\022\036. \200)Tj /Span<>> BDC ( )Tj EMC (\023\024\f\035\036\007\031\033\013\036\n, \007\026\027\027\t\n \023\026\006\ \017\036\027\021\026\n \r)Tj /Span<>> BDC ( )Tj EMC (\031\f\035\024\r\017\016\b )Tj -0.037 Tw T* (\023\036\030\036\r\016\024\004\027\024\020\024 \022\026\002\017\027\036\ \021\026 \023\030\024\r\036\007\036\027\026 \007\030\036\027\017\030\031\ \033\013\026\016 \035\026)Tj 0 Tw (-)Tj 0.015 Tw T* (\021\036\022\f\027\026\016 \035\017\020\026\021\031\030\026 \017 \r)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\017\024\007 \007\024)Tj /Span<>> BDC ( )Tj EMC (3 \n\036\f\016\006\036\r \023\024\f\035\036 \023\036\030)Tj 0 Tw (-)Tj -0.029 Tw T* (\r\017\004\027\024\020\024 \r\n\036\001\026\021\036\035\034\f\021\r\026 \ \f\r\017\013 \035\017\022\r\017\007\017\030\024\r\026\035\f\016 \007\030\ \031\020\017\n )Tj 0.136 Tw T* (\r\026\030\017\026\027\021\024\n \b\017\030\031\030\020\017\004\036\f\022\ \024\020\024 \035\036\004\036\027\017\016: \017\f\f\036\004\036\027\017\036\ \f\r\017)Tj 0 Tw (-)Tj 0.286 Tw T* (\013\026 \f)Tj /Span<>> BDC ( )Tj EMC (\023\035\026\f\021\017\022\024\005 \r\027\031\021\030\036\027\027\036\020\ \024 \f\r\017\013\036\r\024\020\024 \024\021\r\036\030\f\021\017\016 )Tj 0.056 Tw T* [(\f\035\017\017\f\021\024-\n\t\001\036\004\027\t\n )0.5(\035\024\f\022\031\021\024\n \f\021\036\027\022\017 \023\030\016\n\024\005\ \022\017\001\022\017, )]TJ 0.041 Tw T* (\017\f\f\036\004\036\027\017\036 \f\r\017\013\026 \f)Tj /Span<>> BDC ( )Tj EMC (\031\001\017\r\026\027\017\036\n \f\235\017\027\022\021\036\030\026. \230\ \026\022\017\n \024\002)Tj 0 Tw (-)Tj 0.017 Tw T* (\030\026\024\n, \n\036\021\024\007 \224\217\211\003\222 \023\024\022\026\ \026\035 \f\036\002\016 \r)Tj /Span<>> BDC ( )Tj EMC (\022\026\004\036\f\021\r\036 \r\026\032\027\024\020\024 )Tj 0.049 Tw T* (\007\017\026\020\027\024\f\021\017\004\036\f\022\024\020\024 \017\f\f\035\ \036\007\024\r\026\027\017\016, \022\024\021\024\030\024\036 \023\030\017\ )Tj /Span<>> BDC ( )Tj EMC (\023\035\026\027\024)Tj 0 Tw (-)Tj 0.039 Tw T* [(\r\t\b \024\002\f\035\036\007\024\r\026\027\017\016\b )0.5(\023\026\006\017\036\027\021\024\r \r)]TJ /Span<>> BDC ( )Tj EMC (\023\024\f\035\036\024\023\036\030\026\006\017\024\027\027\024\n )Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0 Tw 9 0 0 9 42.5197 730.483 Tm (\020\004\206\f\t\204\004 1.)Tj 0 0 0 1 k /GS1 gs /T1_3 1 Tf ( \206\026\032\026\013\024\031\032\025\t\024\025\013\026 \202\032\205\033\ \033 \025\t\t\023\031\030\n\027\026\021\025\002 \(n)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (121\))Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0 -1.2 TD [(T)48(able 1)47(.)]TJ 0 0 0 1 k /GS1 gs /T1_3 1 Tf [( Character)-36.9(istics of the study g)14.2(roups \(n)]TJ /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (121\))Tj ET 0 0 0 1 K 0.5 w /GS2 gs q 1 0 0 1 42.5197 715.181 cm 0 0 m 210.014 0 l S Q q 1 0 0 1 42.7697 694.3618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 252.5334 715.181 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 252.5334 694.3618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 314.8956 715.181 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 314.8956 694.3618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 377.2579 715.181 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 377.2579 694.3618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 439.6201 715.181 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 439.6201 694.3618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 496.313 694.3618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 42.5197 694.1118 cm 0 0 m 210.014 0 l S Q q 1 0 0 1 42.7697 682.9005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 252.5334 694.1118 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 252.5334 682.9005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 314.8956 694.1118 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 314.8956 682.9005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 377.2579 694.1118 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 377.2579 682.9005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 439.6201 694.1118 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 439.6201 682.9005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 682.6505 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 42.5197 682.6505 cm 0 0 m 210.014 0 l S Q q 1 0 0 1 42.7697 671.4392 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 252.5334 682.6505 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 252.5334 671.4392 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 314.8956 682.6505 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 314.8956 671.4392 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 377.2579 682.6505 cm 0 0 m 62.612 0 l S Q q 1 0 0 1 377.2579 671.4392 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 439.6201 671.4392 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 671.4392 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 42.5197 671.1892 cm 0 0 m 210.014 0 l S Q q 1 0 0 1 42.7697 659.9779 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 252.5334 671.1892 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 252.5334 659.9779 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 314.8956 671.1892 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 314.8956 659.9779 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 377.2579 671.1892 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 377.2579 659.9779 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 439.6201 671.1892 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 439.6201 659.9779 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 659.9779 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 659.7279 cm 0 0 m 210.014 0 l S Q q 1 0 0 1 42.7697 648.5166 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 252.5334 659.7279 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 252.5334 648.5166 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 314.8956 659.7279 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 314.8956 648.5166 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 377.2579 659.7279 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 377.2579 648.5166 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 439.6201 659.7279 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 439.6201 648.5166 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 648.5166 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 648.2666 cm 0 0 m 210.014 0 l S Q q 1 0 0 1 42.7697 598.6553 cm 0 0 m 0 49.361 l S Q q 1 0 0 1 252.5334 648.2666 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 252.5334 598.6553 cm 0 0 m 0 49.361 l S Q q 1 0 0 1 314.8956 648.2666 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 314.8956 598.6553 cm 0 0 m 0 49.361 l S Q q 1 0 0 1 377.2579 648.2666 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 377.2579 598.6553 cm 0 0 m 0 49.361 l S Q q 1 0 0 1 439.6201 648.2666 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 439.6201 598.6553 cm 0 0 m 0 49.361 l S Q q 1 0 0 1 496.313 598.6553 cm 0 0 m 0 49.361 l S Q q 1 0 0 1 42.5197 598.4053 cm 0 0 m 210.014 0 l S Q q 1 0 0 1 42.7697 558.394 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 252.5334 598.4053 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 252.5334 558.394 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 314.8956 598.4053 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 314.8956 558.394 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 377.2579 598.4053 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 377.2579 558.394 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 439.6201 598.4053 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 439.6201 558.394 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 496.313 558.394 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 42.5197 558.144 cm 0 0 m 210.014 0 l S Q q 1 0 0 1 42.7697 518.1328 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 252.5334 558.144 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 252.5334 518.1328 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 314.8956 558.144 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 314.8956 518.1328 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 377.2579 558.144 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 377.2579 518.1328 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 439.6201 558.144 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 439.6201 518.1328 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 496.313 518.1328 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 42.5197 517.8828 cm 0 0 m 210.014 0 l S Q q 1 0 0 1 42.7697 497.0715 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 252.5334 517.8828 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 252.5334 497.0715 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 314.8956 517.8828 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 314.8956 497.0715 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 377.2579 517.8828 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 377.2579 497.0715 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 439.6201 517.8828 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 439.6201 497.0715 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 496.313 497.0715 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 42.5197 496.8215 cm 0 0 m 210.014 0 l S Q q 1 0 0 1 42.7697 485.6102 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 252.5334 496.8215 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 252.5334 485.6102 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 314.8956 496.8215 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 314.8956 485.6102 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 377.2579 496.8215 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 377.2579 485.6102 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 439.6201 496.8215 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 439.6201 485.6102 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 485.6102 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 485.3602 cm 0 0 m 210.014 0 l S Q q 1 0 0 1 42.7697 454.9489 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 252.5334 485.3602 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 252.5334 454.9489 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 314.8956 485.3602 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 314.8956 454.9489 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 377.2579 485.3602 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 377.2579 454.9489 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 439.6201 485.3602 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 439.6201 454.9489 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 496.313 454.9489 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 42.5197 454.6989 cm 0 0 m 210.014 0 l S Q q 1 0 0 1 252.5334 454.6989 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 314.8956 454.6989 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 377.2579 454.6989 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 439.6201 454.6989 cm 0 0 m 56.943 0 l S Q BT /GS1 gs /T1_2 1 Tf 8 0 0 8 105.884 701.7463 Tm (\017\204\r\b\t\004\r\214\013\005 \212\004\006\004\214\r\003\006)Tj 19.985 0.6 Td (\035\020)Tj /Span<>> BDC ( )Tj EMC (+)Tj /Span<>> BDC ( )Tj EMC (\200\255\215\200)Tj 0.474 -1.2 Td (\()Tj /T1_4 1 Tf (n)Tj /T1_2 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (43\))Tj 7.66 1.2 Td (\035\020)Tj /Span<>> BDC ( )Tj EMC (+)Tj /Span<>> BDC ( )Tj EMC (\255\215\035)Tj 0.135 -1.2 Td (\()Tj /T1_4 1 Tf (n)Tj /T1_2 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (47\))Tj 7.692 1.2 Td (\035\020)Tj /Span<>> BDC ( )Tj EMC (+)Tj /Span<>> BDC ( )Tj EMC (\223\026\017)Tj 0.103 -1.2 Td (\()Tj /T1_4 1 Tf (n)Tj /T1_2 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (31\))Tj /T1_4 1 Tf 8.951 0.6 Td (p)Tj /T1_1 1 Tf -52.536 -2.033 Td (\204\031\032\004\017\027\t, )Tj /T1_3 1 Tf (n)Tj /T1_1 1 Tf 29.264 0 Td (29)Tj 7.795 0 Td (34)Tj 7.795 0 Td (19)Tj 6.598 0 Td (0,75**)Tj -51.453 -1.433 Td (\240\036\027\013\017\027\t, )Tj /T1_3 1 Tf (n)Tj /T1_1 1 Tf 29.264 0 Td (14)Tj 7.795 0 Td (13)Tj 7.795 0 Td (12)Tj -44.854 -1.433 Td (\221\030\036\007\027\017\005 \r\024\030\026\f\021, \204\036 \(\017\027\021\ \036\030\r\026\035\) \035\036\021)Tj 27.499 0 Td (41)Tj /Span<>> BDC ( )Tj EMC (\(20\22670\))Tj 7.795 0 Td (45)Tj /Span<>> BDC ( )Tj EMC (\(27\22668\))Tj 7.795 0 Td (40)Tj /Span<>> BDC ( )Tj EMC (\(29\22660\))Tj 8.246 0 Td (>)Tj /Span<>> BDC ( )Tj EMC (0,05*)Tj -51.336 -1.433 Td (\212\035\017\021\036\035\034\027\024\f\021\034 \026\027\026\n\027\036\026\ \026\002\024\035\036\r\026\027\017\016, \204\036 \(\017\027\021\036\030\ \r\026\035\) \n\036\f.)Tj 27.749 0 Td (6)Tj /Span<>> BDC ( )Tj EMC (\(1\226120\))Tj 7.795 0 Td (7)Tj /Span<>> BDC ( )Tj EMC (\(1\226204\))Tj 7.703 0 Td (9,5)Tj /Span<>> BDC ( )Tj EMC (\(1\22684\))Tj 8.089 0 Td (>)Tj /Span<>> BDC ( )Tj EMC (0,05*)Tj -51.336 -1.433 Td (\230\030\026\027\f\f\235\017\027\022\021\036\030\027\t\005 \f\r\017\013,\ )Tj /T1_3 1 Tf (n)Tj /T1_1 1 Tf (:)Tj 1.063 -1.2 Td (\215\024\007\022\024\032\027\026\016 \023\024\030\006\017\016)Tj 0 -1.2 TD (\215\024\r\036\030\b\027\024\f\021\027\026\016 \023\024\030\006\017\016)Tj 0 -1.2 TD (\206\035\031\002\024\022\026\016 \023\024\030\006\017\016)Tj -1.063 -1.2 Td (\224\022\f\021\030\026\f\235\017\027\022\021\036\030\027\t\005 \f\r\017\013\ , )Tj /T1_3 1 Tf (n)Tj /T1_1 1 Tf 29.264 4.8 Td (43)Tj 0.25 -1.2 Td (7)Tj -0.25 -1.2 Td (25)Tj T* (11)Tj 0.25 -1.2 Td (0)Tj 7.545 4.8 Td (39)Tj 0.25 -1.2 Td (3)Tj -0.25 -1.2 Td (19)Tj T* (17)Tj 0.25 -1.2 Td (8)Tj 7.545 4.8 Td (23)Tj 0.25 -1.2 Td (0)Tj -0.25 -1.2 Td (13)Tj T* (10)Tj 0.25 -1.2 Td (8)Tj 6.098 4.8 Td (0,05**)Tj /T1_3 1 Tf (*)Tj /T1_1 1 Tf -51.203 -6.233 Td (\214\024\022\026\035\017\026\006\017\016 \r.\f.\024, )Tj /T1_3 1 Tf (n)Tj /T1_1 1 Tf (:)Tj 1.063 -1.2 Td (\003\026\007\027\016\016)Tj 0 -1.2 TD (\215\036\030\036\007\027\016\016)Tj 0 -1.2 TD (\207\024\022\024\r\026\016)Tj 28.201 2.4 Td (20)Tj 0 -1.2 TD (19)Tj 0.25 -1.2 Td (4)Tj 7.545 2.4 Td (22)Tj T* (20)Tj 0.25 -1.2 Td (5)Tj 7.545 2.4 Td (15)Tj T* (15)Tj 0.25 -1.2 Td (1)Tj 6.598 2.4 Td (0,85*)Tj -51.703 -3.833 Td (\203\026\035\017\004\017\036 \026\021\036\022\024\r, )Tj /T1_3 1 Tf (n)Tj /T1_1 1 Tf (:)Tj 1.063 -1.2 Td (\203\036\021 \026\021\036\022\024\r)Tj T* (\215\024\007\022\024\032\027\t\005)Tj 0 -1.2 TD (\222\001\017\024\026\027\026\035\034\027\t\005)Tj 28.201 2.4 Td (26)Tj 0 -1.2 TD (11)Tj 0.25 -1.2 Td (6)Tj 7.545 2.4 Td (20)Tj T* (14)Tj 0 -1.2 TD (13)Tj 7.795 2.4 Td (19)Tj 0.25 -1.2 Td (6)Tj T* (6)Tj 6.348 2.4 Td (0,29**)Tj -51.453 -3.833 Td (\221 \023\030\036\007\r\026\030\017\021\036\035\034\027\t\n \007\030\036\ \027\017\030\024\r\026\027\017\036\n \035\026\021\036\022\f\027\024\005 \ \035\017\020\026\021\031\030\024\005)Tj 0 -1.2 TD (\207\036 \023\030\036\007\r\026\030\017\021\036\035\034\027\024\020\024\ \007\030\036\027\017\030\024\r\026\027\017\016 \035\026\021\036\022\f\027\ \024\005 \035\017\020\026\021\031\030\024\005)Tj 29.514 1.2 Td (4)Tj -0.25 -1.2 Td (39)Tj 7.795 1.2 Td (16)Tj T* (31)Tj 7.795 1.2 Td (15)Tj T* (16)Tj 5.732 1.2 Td (<)Tj /Span<>> BDC ( )Tj EMC (0,001)Tj /T1_3 1 Tf (***)Tj /T1_1 1 Tf -50.586 -2.633 Td (\215\036\030\017\024\007 \027\026\002\035\033\007\036\027\017\036, \n\036\ \f.)Tj 27.749 0 Td (15)Tj /Span<>> BDC ( )Tj EMC (\(3\22628\))Tj 7.795 0 Td (16)Tj /Span<>> BDC ( )Tj EMC (\(3\22628\))Tj 7.795 0 Td (27)Tj /Span<>> BDC ( )Tj EMC (\(3\22652\))Tj 7.996 0 Td (>)Tj /Span<>> BDC ( )Tj EMC (0,05*)Tj -51.336 -1.433 Td (\200\f\022\030\t\021\017\036 \024. \023\026\030\026\023\030\024\022\021\017\ \021\026:)Tj 1.063 -1.2 Td (\b\017\030\031\030\020\017\004\036\f\022\024\036)Tj T* (\f\026\n\024\f\021\024\016\021\036\035\034\027\024\036)Tj 28.201 1.2 Td (33)Tj T* (10)Tj 7.795 1.2 Td (32)Tj T* (15)Tj 7.795 1.2 Td (15)Tj T* (16)Tj 6.348 2.4 Td (0,057**)Tj /T1_3 1 Tf 7 0 0 7 42.5197 443.2142 Tm (\032\025\003\031\006\026\021\025\031: *)Tj /Span<>> BDC ( )Tj EMC (\227 \032\026\t\006\245\024 \027\020\033\n\023\021\031\021 \t)Tj /Span<>> BDC ( )Tj EMC [(\033\n\003\n\211\022\007 \024\031\t\024\026 \240\026\021\021\026\226\214\ )50.5(\025\024\021\025; **)]TJ /Span<>> BDC ( )Tj EMC (\227 \032\026\t\006\031\024 \027\020\033\n\023\021\031\021 \t)Tj /Span<>> BDC ( )Tj EMC (\033\n\003\n\211\022\007 \013\032\025\024\031\032\025\002 \225\025\001\031\ \032\026; ***)Tj /Span<>> BDC ( )Tj EMC (\227 \032\026\016\023\025\006\025\002 \003\031\204\030\205 )Tj T* [(\033\n\013\026\016\026)49(\024\031\023\002\003\025 1-\017 \025)]TJ /Span<>> BDC ( )Tj EMC (2-\017 \202\032\205\033\033\020, 1-\017 \025)Tj /Span<>> BDC ( )Tj EMC [(3-\017 \202\032\205\033\033\020 \t\024\026)49.4(\024\025\t\024\025\006\031\t\013\025 \016\021\026\006\025\003\020 \(\024\ \031\t\024 \225\025\001\031\032\026\))]TJ 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\033\030\031\030\213\b)-20.9(\035\231\213\233\t \021\032)50(\b)42(\032\231\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj /T1_5 1 Tf 25 0 0 25 512.7895 56.0378 Tm (65)Tj ET endstream endobj 1931 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.157 Tw 10 0 0 10 70.8661 724.8299 Tm (\220\023\017\021\036\035\017\017\030\024\r\026\027\t; \023\030\017\027\ \026\022\024\r \r\024\r\030\026\021\026 \026\002\024\035\036\r\026\027\ \017\016 )Tj 0 Tw 0 -1.218 TD (\r\t\016\r\035\036\027\024 \027\036 \002\t\035\024.)Tj -0.064 Tw T* (\230\026\022\032\036 \r)Tj /Span<>> BDC ( )Tj EMC (\030\026\n\022\026\b \023\030\024\021\024\022\024\035\026 \022\035\017\027\ \017\004\036\f\022\017\b \017\f\f\035\036\007\024\r\026\027\017\005 )Tj 0.234 Tw T* (\007\035\016 \024\006\036\027\022\017 \r\035\017\016\027\017\016 \024\023\ \036\030\026\006\017\005 \027\026)Tj /Span<>> BDC ( )Tj EMC (\235\031\027\022\006\017\024\027\026\035\034\027\024\036 )Tj 0.253 Tw T* (\f\024\f\021\024\016\027\017\036 \026\023\017\030\026\021\036\035\034\027\ \024\020\024 \026\023\023\026\030\026\021\026 \023\030\016\n\024\005 \022\ \017\001\022\017 )Tj 0.1 Tw T* (\007\024)Tj /Span<>> BDC ( )Tj EMC (\r\n\036\001\026\021\036\035\034\f\021\r\026 \017)Tj /Span<>> BDC ( )Tj EMC (\004\036\030\036 3 \n\036\f\016\006\026 \023\024\f\035\036 \024\023\036\ \030\026\006\017\017 )Tj 1.129 Tw 0 -1.218 TD (\r\t\023\024\035\027\016\035\026\f\034 \f\235\017\027\022\021\036\030\024\ \n\036\021\030\017\016. \212\024\023\024\035\027\017\021\036\035\034\027\ \024 )Tj 0.245 Tw 0 -1.218 TD [(\023\030\024\r\024\007\017\035\024\f\034 \026\027\022\036\021\017\030\024\ \r\026\027\017\036 )0.5(\023\026\006\017\036\027\021\024\r \f)]TJ /Span<>> BDC ( )Tj EMC (\023\024\n\024\013\034\033 )Tj 0.007 Tw T* [(\001\022\026\035\t \026\027\026\035\034\027\024\005 )0.5(\017\027\022\024\027\021\017\027\036\027\006\017\017 )0.6(W)22(e)-18(xner \(0 \002\026\035\035\024\r)]TJ /Span<>> BDC ( )Tj EMC 21.11 0 Td (\227 )Tj 0.044 Tw -21.11 -1.218 Td (\027\024\030\n\026\035\034\027\026\016 \235\031\027\022\006\017\016 \007\ \036\030\032\026\027\017\016, 20 \002\026\035\035\024\r)Tj /Span<>> BDC ( )Tj EMC (\227 \027\036\007\036\030)Tj 0 Tw (-)Tj 0.345 Tw T* [(\032\026\027\017\036 \r\f\036\b \022\024\n\023\024\027\036\027\021\024\r\ )0.5(\022\017\001\036\004\027\024\020\024 \f\024\007\036\030\032\017\n\024\020\ \024 )]TJ 0.02 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\027\026\030\031\001\036\027\017\036\n \022\026\004\036\f\021\r\026 \032\ \017\027\017 \017)Tj /Span<>> BDC ( )Tj EMC (\027\036\024\002\b\024\007\017\n\024\f\021\034\033 \030\036)Tj 0 Tw (-)Tj 0 -1.218 TD (\020\031\035\016\030\027\024\020\024 \027\024\001\036\027\017\016 \023\030\ \024\022\035\026\007\024\022\).)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 70.936 542.1598 Tm [(\033\034\020)21(\223)50(\r\241)46(\024)52(\026)45(\024\232)]TJ 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0 Tc 0.209 Tw 10 0 0 10 70.8661 517.8038 Tm (\210\023\036\030\026\021\017\r\027\t\036 \r\n\036\001\026\021\036\035\034\ \f\021\r\026 \f)Tj /Span<>> BDC ( )Tj EMC (\023\030\017\n\036\027\036\027\017\036\n \035\026\036\030)Tj 0 Tw (-)Tj 0.095 Tw 0 -1.218 TD (\027\024\005 \022\024\026\020\031\035\016\006\017\017 \f)Tj /Span<>> BDC ( )Tj EMC (\030\026\035\017\004\027\t\n\017 \r\026\030\017\026\027\021\026\n\017 \ \026\022\030\t\021\017\016 )Tj 0.177 Tw T* (\r\027\031\021\030\036\027\027\036\020\024 \f\r\017\013\036\r\024\020\024\ \024\021\r\036\030\f\021\017\016 \002\t\035\017 \r\t\023\024\035\027\036\ \027\t )Tj 0.14 Tw T* (121 \023\026\006\017\036\027\021\031. \200)Tj /Span<>> BDC ( )Tj EMC (\026\r\017\f\017\n\024\f\021\017 \024\021 \r\026\030\017\026\027\021\026\ \026\022\030\t\021\017\016 )Tj 0.076 Tw T* (\r\027\031\021\030\036\027\027\036\020\024 \f\r\017\013\036\r\024\020\024\ \024\021\r\036\030\f\021\017\016 \023\026\006\017\036\027\021\t \030\026\ \f\023\030\036)Tj 0 Tw (-)Tj 0.091 Tw T* (\007\036\035\017\035\017\f\034 \f\035\036\007\031\033\013\017\n \024\002\ \030\026\024\n: \035\026\036\030\027\026\016 \022\024\026\020\031\035\016\ \006\017\016 )Tj 0 Tw T* [(\f\r\017\013\036\r\024\020\024 )0.5(\b\024\007\026 )0.6(\f)]TJ /Span<>> BDC ( )Tj EMC 7.453 0 Td [(\031\001\017\r\026\027\017\036\n )0.6(\r\027\031\021\030\036\027\027\036\020\024 )0.5(\f\r\017\013\036\r\024\020\024 )]TJ 0.026 Tw -7.453 -1.218 Td (\024\021\r\036\030\f\021\017\016 \(\214\230)Tj /Span<>> BDC ( )Tj EMC (+)Tj /Span<>> BDC ( )Tj EMC (\211\200\210\))Tj /Span<>> BDC ( )Tj EMC (\227 31 \023\026\006\017\036\027\021; \035\026\036\030\027\026\016 \022\ \024\026\020\031)Tj 0 Tw (-)Tj 0.037 Tw T* (\035\016\006\017\016 \f\r\017\013\026 \f)Tj /Span<>> BDC ( )Tj EMC (\023\035\026\f\021\017\022\024\005 \r\027\031\021\030\036\027\027\036\020\ \024 \f\r\017\013\036\r\024\020\024 \024\021)Tj 0 Tw (-)Tj 0.026 Tw T* (\r\036\030\f\021\017\016 \f\035\017\017\f\021\024-\n\t\001\036\004\027\t\ \n \035\024\f\022\031\021\024\n \(\214\230)Tj /Span<>> BDC ( )Tj EMC (+)Tj /Span<>> BDC ( )Tj EMC (\221\204\214\))Tj /Span<>> BDC ( )Tj EMC (\227 )Tj 0.106 Tw T* (47 \023\026\006\017\036\027\021\024\r; \035\026\036\030\027\026\016 \022\ \024\026\020\031\035\016\006\017\016 \f\r\017\013\036\r\024\020\024 \b\024\ \007\026 )Tj 0.286 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\f\024\004\036\021\026\027\017\017 \f)Tj /Span<>> BDC ( )Tj EMC (\036\020\024 \023\036\030\036\r\016\022\024\005 \r)Tj /Span<>> BDC ( )Tj EMC (\n\036\032\f\235\017\027\022\021\036\030\027\024\n )Tj -0.058 Tw T* (\023\030\024\f\021\030\026\027\f\021\r\036 \(\214\230)Tj /Span<>> BDC ( )Tj EMC (+)Tj /Span<>> BDC ( )Tj EMC (\215\221\204\215\))Tj /Span<>> BDC ( )Tj EMC (\227 43 \023\026\006\017\036\027\021\026. \221\035\036\007\031\036\021 \024\ \021)Tj 0 Tw (-)Tj 0.047 Tw T* [(\n\036\021\017\021\034, )0.5(\004\021\024 \023\026\006\017\036\027\021\t )0.5(\r\022\035\033\004\026\035\017\f\034 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC (\030\026\n\022\026\b \030\026\027\007\024\n\017)Tj 0 Tw (-)Tj 0.108 Tw T* (\017\030\024\r\026\027\027\t\b \017\f\f\035\036\007\024\r\026\027\017\005\ , \004\021\024 \024\002\031\f\035\026\r\035\017\r\026\035\024 \f\b\024\007\ )Tj 0 Tw (-)Tj 0.075 Tw T* (\027\t\005 \f\024\f\021\026\r \020\030\031\023\023. \213\007\017\027\f\021\ \r\036\027\027\t\n \024\021\035\017\004\017\036\n \016\r\035\016\035\024\ \f\034 )Tj 0.174 Tw T* [(\r\022\035\033\004\036\027\017\036 \023\026\006\017\036\027\021\024\r )0.5(\021\024\035\034\022\024 \f)]TJ /Span<>> BDC ( )Tj EMC (\021\030\026\027\f\f\235\017\027\022\021\036\030\027\t\n\017 )Tj -0.004 Tw T* (\f\r\017\013\026\n\017 \r)Tj /Span<>> BDC ( )Tj EMC (\017\f\f\035\036\007\024\r\026\027\017\017 2, \021\024\020\007\026 \022\026\ \022 \r)Tj /Span<>> BDC ( )Tj EMC (\017\f\f\035\036\007\024\r\026\027\017\017 )Tj 0.269 Tw T* (1 \r\b\024\007\017\035\017 \021\026\022\032\036 \023\026\006\017\036\027\ \021\t \f)Tj /Span<>> BDC ( )Tj EMC (\220\022\f\021\030\026\f\235\017\027\022\021\036\030\027\t\n\017 )Tj 0.081 Tw T* (\f\r\017\013\026\n\017 1\2262)Tj /Span<>> BDC ( )Tj EMC (\f\021\036\023\036\027\017 \f\035\024\032\027\024\f\021\017. \204\036\007\ \017\026\027\026 \f\030\036\007\027\036\020\024 )Tj -0.032 Tw T* (\023\036\030\017\024\007\026 \027\026\002\035\033\007\036\027\017\016 \026\ )Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\026\n\017 \f\024\f\021\026\r\017\035\026 16\ )Tj /Span<>> BDC ( )Tj EMC (\(3\226)Tj 0 Tw T* (52\) \n\036\f\016\006\036\r.)Tj 0.004 Tc 0.069 Tw T* (\215\024 \023\024\035\031, \r\024\030\026\f\021\031, \035\024\022\026\035\ \017\026\006\017\017 \r\027\031\021\030\036\027\027\036\020\024 \f\r\017\ \013\036)Tj 0 Tc 0 Tw (-)Tj 0.004 Tc 0.3 Tw T* (\r\024\020\024 \024\021\r\036\030\f\021\017\016, \027\026\035\017\004\017\ \033/\024\021\f\031\021\f\021\r\017\033 \023\026\030\026\030\036\022\021\ \026\035\034)Tj 0 Tc 0 Tw (-)Tj 0.004 Tc 0.133 Tw T* [(\027\t\b \026\021\036\022\024\r, \007\035\017\021\036\035\034\027\024\f\ \021\034\033 \026\027\026\n\027\036\026 \026\002\024\035\036\r\026\027\ \017\016,)4( )]TJ 0.489 Tw T* [(\f\026\n\024\f\021\024\016\021\036\035\034\027\024\n\031 \017\035\017 \b\ \017\030\031\030\020\017\004\036\f\022\024\n\031 \r\f\022\030\t\021\017\033\ )4( )]TJ -0.054 Tw T* (\024\f\021\030\024\020\024 \023\026\030\026\023\030\024\022\021\017\021\026\ \031\f\035\024\r\027\t\036 \020\030\031\023\023\t \027\036 \017\n\036\035\ \017 \f\021\026)Tj 0 Tc 0 Tw (-)Tj 0.004 Tc -0.009 Tw T* (\021\017\f\021\017\004\036\f\022\017 \027\026\004\017\n\t\b \030\026\035\ \017\004\017\005 \(\230\026\002\035.)Tj /Span<>> BDC ( )Tj EMC [(1\). \221\021\026\021\017\004\036\f\022\017)4( )]TJ 0.469 Tw T* [(\027\026\004\017\n\t\036 \030\026\035\017\004\017\016 \n\036\032\007\031\ )0.5(\020\030\031\023\023\024\005 \214\230)]TJ /Span<>> BDC ( )Tj EMC (+)Tj /Span<>> BDC ( )Tj EMC [(\215\221\204\215)4( )]TJ 0.208 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\026\n\017 \214\230)Tj /Span<>> BDC ( )Tj EMC (+)Tj /Span<>> BDC ( )Tj EMC (\221\204\214 \017)Tj /Span<>> BDC ( )Tj EMC (\214\230)Tj /Span<>> BDC ( )Tj EMC (+)Tj /Span<>> BDC ( )Tj EMC [(\211\200\210 \002\t\035\017 \r\t\016\r\035\036\027\t)4( )]TJ 0.093 Tw T* (\023\030\017)Tj /Span<>> BDC ( )Tj EMC [(\f\030\026\r\027\036\027\017\017 \r\026\030\017\026\027\021\024\r \030\026\ \f\023\024\035\024\032\036\027\017\016 \f\r\017\013\036\r\024\020\024)4( )]TJ 0.019 Tw T* [(\b\024\007\026 \024\021\027\024\f\017\021\036\035\034\027\024 \027\026\030\ \031\032\027\024\020\024 \026\027\026\035\034\027\024\020\024 \f\235\017\ \027\022\021\036\030\026.)4( )]TJ 0.142 Tw T* [(\200\t\016\r\035\036\027\027\t\036 \030\026\035\017\004\017\016 \002\t\035\ \017 \024\002\031\f\035\024\r\035\036\027\t \030\026\027\017\006\036\005\ )3.9( )]TJ 0.074 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\022\030\017\021\036\030\017\016\b \r\022\035\033\004\036\027\017\016 \r\ )Tj /Span<>> BDC ( )Tj EMC (\017\f\f\035\036\007\024\r\026\027\017\016, \021.\022. \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023)Tj 0 Tc 0 Tw (-)Tj 0.004 Tc 0.147 Tw T* (\023\031, \020\007\036 \035\026\036\030\027\026\016 \021\036\030\n\024\022\ \024\026\020\031\035\016\006\017\016 \f\024\004\036\021\026\035\026\f\034\ \f)Tj /Span<>> BDC ( )Tj EMC (\023\036)Tj 0 Tc 0 Tw (-)Tj 0.004 Tc 0.342 Tw T* (\030\036\r\016\022\024\005 \f\r\017\013\026 \r)Tj /Span<>> BDC ( )Tj EMC [(\n\036\032\f\235\017\027\022\021\036\030\027\024\n \023\030\024\f\021\030\ \026\027\f\021\r\036)3.9( )]TJ 0.256 Tw T* (\r\022\035\033\004\026\035\017\f\034 \021\024\035\034\022\024 \023\026\006\ \017\036\027\021\t \f)Tj /Span<>> BDC ( )Tj EMC [(\021\030\026\027\f\f\235\017\027\022\021\036\030\027\t\n)3.9( )]TJ 0.304 Tw 23.244 64.543 Td (\030\026\f\023\024\035\024\032\036\027\017\036\n \f\r\017\013\036\r\024\020\ \024 \b\024\007\026. \230\026\022\032\036 \002\t\035\017 \r\t)Tj 0 Tc 0 Tw (-)Tj 0.004 Tc 0.46 Tw 0 -1.218 TD [(\016\r\035\036\027\t \f\021\026\021\017\f\021\017\004\036\f\022\017\036 \ \030\026\035\017\004\017\016 \n\036\032\007\031 \020\030\031\023\023\024\ \005)4( )]TJ 0.043 Tw 0 -1.218 TD (\214\230)Tj /Span<>> BDC ( )Tj EMC (+)Tj /Span<>> BDC ( )Tj EMC (\215\221\204\215 \f)Tj /Span<>> BDC ( )Tj EMC (2 \007\030\031\020\017\n\017 \020\030\031\023\023\026\n\017 \023\024)Tj /Span<>> BDC ( )Tj EMC [(\004\026\f\021\024\021\036 \f\035\031\004\026\036\r)4( )]TJ 0.159 Tw 0 -1.218 TD (\023\030\036\007\r\026\030\017\021\036\035\034\027\024\020\024 \007\030\036\ \027\017\030\024\r\026\027\017\016 \f\r\017\013\026 \f)Tj /Span<>> BDC ( )Tj EMC [(\023\024\n\024\013\034\033)4( )]TJ 0.134 Tw 0 -1.218 TD (\035\026\021\036\022\f\027\024\005 \035\017\020\026\021\031\030\t, \021.\ \022. \r)Tj /Span<>> BDC ( )Tj EMC (\007\026\027\027\031\033 \020\030\031\023\023\031 \027\036 \r\022\035\033\ )Tj 0 Tc 0 Tw (-)Tj 0.004 Tc 0.169 Tw 0 -1.218 TD (\004\026\035\017\f\034 \023\026\006\017\036\027\021\t \f)Tj /Span<>> BDC ( )Tj EMC (\020\035\031\002\024\022\017\n\017 \026\021\036\022\026\n\017 \017, \f\024\ \024\021\r\036\021)Tj 0 Tc 0 Tw (-)Tj 0.004 Tc 0.316 Tw T* (\f\021\r\036\027\027\024, \007\r\031\b\220\021\026\023\027\024\036 \035\036\ \004\036\027\017\036 \023\030\017\n\036\027\016\035\024\f\034 \f\031\013\ \036)Tj 0 Tc 0 Tw (-)Tj 0.004 Tc T* (\f\021\r\036\027\027\024 \030\036\032\036.)Tj 0 Tc 0.277 Tw T* [(\215\030\017 )0.5(\r\f\036\b )0.5(\r\026\030\017\026\027\021\026\b )0.6(\026\022\030\t\021\017\016 )0.5(\r\027\031\021\030\036\027\027\036\020\024 )0.6(\f\r\017\013\036)]TJ 0 Tw (-)Tj 0.288 Tw T* [(\r\024\020\024 \024\021\r\036\030\f\021\017\016 \023\024\035\024\032\017\ \021\036\035\034\027\t\n )0.5(\017\f\b\024\007\024\n \024\023\036\030\026\006\017\017 )]TJ 0.193 Tw T* (\f\004\017\021\026\035\024\f\034 \023\024\035\027\024\036 \036\020\024 \ \026\032\017\r\035\036\027\017\036 \r\n\036\f\021\036 \f)Tj /Span<>> BDC ( )Tj EMC (\027\026\030\031\032)Tj 0 Tw (-)Tj 0.129 Tw T* (\027\t\n \024\021\r\036\030\f\021\017\036\n. \221)Tj /Span<>> BDC ( )Tj EMC (\031\004\036\021\024\n \r\f\036\b \r\026\030\017\026\027\021\024\r \026\ \022\030\t\021\017\016 )Tj -0.013 Tw T* [(\r\027\031\021\030\036\027\027\036\020\024 \f\r\017\013\036\r\024\020\024\ )0.5(\024\021\r\036\030\f\021\017\016 \026\032\017\r\035\036\027\017\036 \f\r\ \017\013\026 )]TJ 0.007 Tw T* (\024\021\n\036\004\036\027\024 \r)Tj /Span<>> BDC ( )Tj EMC (83/121 \(68,6%\) \027\026\002\035\033\007\036\027\017\016\b, \030\036\006\ \017\007\017\r)Tj /Span<>> BDC ( )Tj EMC (\227 )Tj 0.028 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC 0.734 0 Td [(38/121 )0.5(\(31,4%\) )0.5(\027\026\002\035\033\007\036\027\017\016\b. )0.6(\217\026\f\f\n\026\021\030\017\r\026\016 )0.5(\031\f\035\024\r)]TJ 0 Tw (-)Tj 0.109 Tw -0.734 -1.218 Td [(\027\t\036 )0.5(\020\030\031\023\023\t )0.5(\024\021\007\036\035\034\027\024, )0.6(\023\024\f\035\036 )0.5(\214\230)]TJ /Span<>> BDC ( )Tj EMC 13.613 0 Td (+)Tj /Span<>> BDC ( )Tj EMC 0.841 0 Td [(\215\221\204\215 )0.5(\026\032\017\r\035\036\027\017\036 )]TJ 0.021 Tw -14.455 -1.218 Td (\f\r\017\013\026 \024\021\n\036\004\036\027\024 \031)Tj /Span<>> BDC ( )Tj EMC (33)Tj /Span<>> BDC ( )Tj EMC (\(76,7%\) \017)Tj /Span<>> BDC ( )Tj EMC (43 \023\026\006\017\036\027\021\024\r. \221\030\036\007\017 )Tj 0.147 Tw T* (10 \(23,3%\) \f\035\031\004\026\036\r \030\036\006\017\007\017\r\026 \f\r\ \017\013\026, \r)Tj /Span<>> BDC ( )Tj EMC (\026\r\017\f\017\n\024\f\021\017 )Tj 0.073 Tw T* (\024\021 \f\024\b\030\026\027\016\033\013\036\005\f\016 \004\026\f\021\017\ \b\024\007\026, \n\024\032\027\024 \030\026\f\f\n\026\021\030\017\r\026\ \021\034 )Tj 0.076 Tw T* (3 \024\f\027\024\r\027\t\b \021\017\023\026: 1\))Tj /Span<>> BDC ( )Tj EMC (\031)Tj /Span<>> BDC ( )Tj EMC (3 \023\026\006\017\036\027\021\024\r \023\030\024\017\024\001\036\035 \023\ \036\030\036)Tj 0 Tw (-)Tj 0.227 Tw T* (\b\024\007 \021\030\026\027\f\f\235\017\027\022\021\036\030\027\024\020\024\ \f\r\017\013\026 \r)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\036\036 \023\030\024\f\021\024\005)Tj /Span<>> BDC ( )Tj EMC (\227 )Tj 0.213 Tw T* (\017\027\021\036\030\f\235\017\027\022\021\036\030\027\t\005, \021\024 \036\ \f\021\034 \023\030\024\017\024\001\035\024 \026\032\017\r\035\036\027\ \017\036 )Tj 0.091 Tw T* (\004\026\f\021\017 \f\r\017\013\026, \017\007\031\013\036\005 \r)Tj /Span<>> BDC ( )Tj EMC (\021\024\035\013\036 \027\026\030\031\032\027\024\020\024 \f\235\017\027\ \022\021\036\030\026, )Tj 0.079 Tw T* (\023\030\017)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\n \f\024\b\030\026\027\016\035\f\016 \031\004\026\f\021\024\ \022 \f\r\017\013\036\r\024\020\024 \b\024\007\026 \n\036\032\007\031 )Tj 0.242 Tw T* (\030\026\027\024\005 \r)Tj /Span<>> BDC ( )Tj EMC (\024\002\035\026\f\021\017 \n\036\032\f\235\017\027\022\021\036\030\027\024\ \005 \002\024\030\024\007\t \017)Tj /Span<>> BDC ( )Tj EMC (\r\027\031)Tj 0 Tw (-)Tj 0.059 Tw T* [(\021\030\036\027\027\017\n )0.6(\f\r\017\013\036\r\t\n )0.5(\024\021\r\036\030\f\021\017\036\n; )0.6(2\))]TJ /Span<>> BDC ( )Tj EMC 14.737 0 Td (\031)Tj /Span<>> BDC ( )Tj EMC 0.736 0 Td (4)Tj /Span<>> BDC ( )Tj EMC 0.791 0 Td [(\023\026\006\017\036\027\021\024\r )0.6(\024\021)]TJ 0 Tw (-)Tj 0.119 Tw -16.265 -1.218 Td (\n\036\004\036\027\024 \f\024\b\030\026\027\036\027\017\036 \f\r\017\013\ \026 \002\036 \r\t\030\026\032\036\027\027\t\b \017\n\036\027\036)Tj 0 Tw (-)Tj -0.06 Tw T* (\027\017\005; 3\))Tj /Span<>> BDC ( )Tj EMC (\031)Tj /Span<>> BDC ( )Tj EMC (3 \023\026\006\017\036\027\021\024\r \f\r\017\013 \023\036\030\036\001\036\ \035 \r)Tj /Span<>> BDC ( )Tj EMC (\021\026\022 \027\026\t\r\026\036\n\t\005 )Tj 0.224 Tw T* (\253\027\036\023\024\035\027\t\005 \027\026\030\031\032\027\t\005 \f\r\017\ \013\273, \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\n \r\t\016\r\035\016\035\024\f\034 )Tj 0.36 Tw T* [(\f\024\024\002\013\036\027\017\036 \n\036\032\007\031 )0.5(\027\026\030\031\032\027\t\n \f\r\017\013\036\r\t\n \024\021\r\036\030\f\ \021\017)]TJ 0 Tw (-)Tj 0.095 Tw T* (\036\n \017)Tj /Span<>> BDC ( )Tj EMC (\027\036 \007\024)Tj /Span<>> BDC ( )Tj EMC (\022\024\027\006\026 \026\032\017\r\001\036\005 \030\026\027\024\005 \r\ )Tj /Span<>> BDC ( )Tj EMC (\023\030\024\036\022\006\017\017 \n\036\032)Tj 0 Tw (-)Tj 0.343 Tw T* (\f\235\017\027\022\021\036\030\027\024\005 \002\024\030\024\007\t, \024\ \007\027\026\022\024 \f\r\016\017 \f)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\f\r\036\021\024\n )Tj 0.312 Tw T* (\023\030\016\n\024\005 \022\017\001\022\017 \027\036 \024\021\n\036\004\026\ \035\024\f\034. \215\024\f\035\036 2-\b \n\036\f\016\006\036\r )Tj 0.108 Tw T* (\007\017\027\026\n\017\004\036\f\022\024\020\024 \027\026\002\035\033\007\ \036\027\017\016 \023\026\006\017\036\027\021\026\n \f)Tj /Span<>> BDC ( )Tj EMC (\030\036\006\017\007\017\r\024\n )Tj 0.121 Tw T* (\f\r\017\013\026 1-\020\024 \021\017\023\026 \r\t\023\024\035\027\036\027\ \024 \017\f\f\036\004\036\027\017\036 \n\024\f\021\017\022\026 \021\022\026\ )Tj 0 Tw (-)Tj 0.14 Tw T* (\027\036\005 \n\036\032\007\031 \r\027\031\021\030\036\027\027\017\n \024\ \021\r\036\030\f\021\017\036\n \017)Tj /Span<>> BDC ( )Tj EMC (\030\026\027\024\005 \r)Tj /Span<>> BDC ( )Tj EMC (\024\002\035\026)Tj 0 Tw (-)Tj 0.134 Tw T* (\f\021\017 \n\036\032\f\235\017\027\022\021\036\030\027\024\005 \002\024\ \030\024\007\t \r)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\f\r\036\021 \022\017\001\022\017 \023\024\007 )Tj -0.029 Tw T* (\n\036\f\021\027\024\005 \026\027\036\f\021\036\017\036\005. \215\030\017\ )Tj /Span<>> BDC ( )Tj EMC (\030\036\006\017\007\017\r\026\b 2-\020\024 \017)Tj /Span<>> BDC ( )Tj EMC (3-\020\024 \021\017\023\024\r )Tj 0.015 Tw T* (\023\026\006\017\036\027\021\026\n \r\t\023\024\035\027\036\027\024 \017\ \f\f\036\004\036\027\017\036 \f\r\017\013\026 \f)Tj /Span<>> BDC ( )Tj EMC (\031\001\017\r\026\027\017\036\n )Tj 0.018 Tw T* (\f\235\017\027\022\021\036\030\026. \215\030\017)Tj /Span<>> BDC ( )Tj EMC (\024\006\036\027\022\036 \030\036\031\035\034\021\026\021\024\r \r)Tj /Span<>> BDC ( )Tj EMC (\023\024\f\035\036\024\023\036\030\026\006\017)Tj 0 Tw (-)Tj 0.115 Tw T* (\024\027\027\024\n \023\036\030\017\024\007\036, \023\030\036\r\t\001\026\ \033\013\036\n 3 \n\036\f\016\006\026, \030\036\006\017\007\017\r\024\r \ )Tj 0 Tw T* (\026\002\024\035\036\r\026\027\017\016 \027\036 \024\021\n\036\004\036\027\ \024.)Tj 0.109 Tw T* (\200 \020\030\031\023\023\036 \035\026\036\030\027\024\005 \022\024\026\ \020\031\035\016\006\017\017 \r)Tj /Span<>> BDC ( )Tj EMC (\022\024\n\002\017\027\026\006\017\017 \f)Tj /Span<>> BDC ( )Tj EMC (\027\017)Tj 0 Tw (-)Tj 0.195 Tw T* [(\r\036\007\036\027\017\036\n )0.6(\f\035\017\017\f\021\024-\n\t\001\036\004\027\024\020\024 )0.6(\035\024\f\022\031\021\026 )0.5(\026\032\017\r\035\036\027\017\036 )]TJ -0.047 Tw T* (\f\r\017\013\026 \024\021\n\036\004\036\027\024 \r)Tj /Span<>> BDC ( )Tj EMC (35)Tj /Span<>> BDC ( )Tj EMC (\(74,4%\) \017)Tj /Span<>> BDC ( )Tj EMC (47 \f\035\031\004\026\036\r. \200)Tj /Span<>> BDC ( )Tj EMC (3)Tj /Span<>> BDC ( )Tj EMC (\f\035\031\004\026)Tj 0 Tw (-)Tj 0.069 Tw T* [(\016\b, )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 2.178 0 Td [(\002\035\017\032\026\005\001\036\n )0.5(\023\024\f\035\036\024\023\036\030\026\006\017\024\027\027\024\n )0.5(\023\036\030\017\024\007\036, )0.6(\002\t\035\017 )]TJ -0.006 Tw -2.178 -1.218 Td (\026\235\017\022\f\017\030\024\r\026\027\t \024\f\035\024\032\027\036\027\ \017\016 \r)Tj /Span<>> BDC ( )Tj EMC (\r\017\007\036 \030\026\r\017\021\017\016 \024\f\021\030\024\020\024 )Tj -0.063 Tw T* (\023\026\030\026\023\030\024\022\021\017\021\026. \210\002\024\f\021\030\ \036\027\017\036 \r\024\f\023\026\035\017\021\036\035\034\027\024\020\024\ \023\030\024\006\036\f\f\026 )Tj -0.011 Tw T* (\031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \023\030\024\017\024\001\035\024 \027\ \026)Tj /Span<>> BDC ( )Tj EMC (5-\036, 7-\036 \017)Tj /Span<>> BDC ( )Tj EMC (17-\036 \f\031\021\022\017 \023\024\f\035\036 )Tj 0.134 Tw T* (\024\023\036\030\026\021\017\r\027\024\020\024 \r\n\036\001\026\021\036\035\ \034\f\021\r\026. \200\f\036\n \023\026\006\017\036\027\021\026\n \002\t\ \035\024 )Tj 0.306 Tw T* (\r\t\023\024\035\027\036\027\024 \r\f\022\030\t\021\017\036 \023\026\030\ \026\023\030\024\022\021\017\021\026 \f)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\r\036\007\036\027\017\036\n )Tj 0.183 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\f\r\017\013\036\r\024\005 \b\024\007 \007\030\036\027\017\030\031\033\013\ \036\005 \035\026\021\036\022\f\027\024\005 \035\017\020\026\021\031\030\ \t. )Tj 0.136 Tw T* [(\200\036\030\024\016\021\027\024\005 \023\030\017\004\017\027\024\005 )0.5(\024\f\035\024\032\027\036\027\017\016 \016\r\035\016\035\024\f\034 )0.5(\002\t\f\021\030\024\036 )]TJ 0.151 Tw T* [(\f\022\035\036\017\r\026\027\017\036 )0.6(\030\026\027\t )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 8.507 0 Td [(\023\030\024\036\022\006\017\017 )0.5(\030\026\027\036\036 )0.6(\f\031\013\036\f\021\r\031\033\013\036\020\024 )]TJ 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0 Tw 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\033\030\031\030\213\b)-20.9(\035\231\213\233\t \021\032)50(\b)42(\032\231\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj -51.938 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 23, \023\0221)69(, 202)69(4)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 23, \023\0221)69(, 202)69(4)]TJ /T1_3 1 Tf 25 0 0 25 28.2026 56.0378 Tm (64)Tj ET endstream endobj 1924 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\034\205\026\220\007\016\026\001\220\203 \025\221\020\026 \221\002\220\024\ \016\001\016\001\220\205 \024\016\026)11.1(\025\201\013 \007\013\222\016\002\001\025\203 \n)10(\025\013\202)-20(\215\007\205\227\220\220 )]TJ 0 -1 TD [(\221\002\220\022\007\016\017\016\001\220\220 \026\002\013\001\006- \220\022\ \232\n\006)-10(\026\002\013\006\225\220\001\n)-9.9(\026)11(\016\002\001\020\207 \006\r\220\224\016\203 \221\002\205\024\025\203 \n\220\ \n\220)]TJ 37.587 1 Td [(Fiv)12(e)-52(-y)10(ear e)21(xperience of laser coagulation in th)11(e tr)31(eatment )]TJ 6.214 -1 Td [(of tr)21.1(ans- and supr)21.1(asphincteric anal f)-20.9(istulas)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0.07 Tw 10 0 0 10 42.5197 724.8299 Tm [(\032\017\007\022\024\f\021\027\t\b \r\022\035\033\004\036\027\017\005 )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC (\023\024\027\017\032\036\027\027\024\005 \220\b\024\020\036\027\027\024\f\ \021\034\033 )Tj 0.141 Tw 0 -1.218 TD (\(\217\017\f.)Tj /Span<>> BDC ( )Tj EMC 2.505 0 Td [(2\207\). )0.5(\215\030\017)]TJ /Span<>> BDC ( )Tj EMC 4.089 0 Td [(\023\024\f\035\036\007\031\033\013\036\n )0.6(\224\217\211\003\222 )0.5(\004\036\030\036 )0.6(2 )0.5(\n\036\f\016\006\026 )]TJ 0.119 Tw -6.594 -1.218 Td (\(\217\017\f.)Tj /Span<>> BDC ( )Tj EMC (2\200\) \024\027\026 \024\023\036\030\026\006\017\016 \023\030\036\007\f\ \021\026\r\035\036\027\026 \235\017\002\030\024\027\t\n\017 )Tj 0.045 Tw T* [(\021\022\026\027\016\n\017 \f\030\036\007\027\036\005 \020\017\023\024\220\ \b\024\020\036\027\027\024\f\021\017, )0.5(\004\021\024 \f\024\024\021\r\036\021\f\021\r\031\036\021 )]TJ 0.064 Tw 23.244 3.653 Td (\235\024\030\n\017\030\024\r\026\027\017\033 \030\031\002\006\024\r\024\005\ \021\022\026\027\017, \026\032\017\r\035\036\027\017\033 \f\r\017\013\026\ . )Tj -0.029 Tw T* (\215\030\017)Tj /Span<>> BDC ( )Tj EMC (\022\035\017\027\017\004\036\f\022\024\n \024\f\n\024\021\030\036 \031)Tj /Span<>> BDC ( )Tj EMC (\007\026\027\027\024\020\024 \023\026\006\017\036\027\021\026 \022\026\022\ \027\026)Tj 0 Tw (-)Tj 0.085 Tw T* (\030\031\032\027\024\036, \021\026\022 \017)Tj /Span<>> BDC ( )Tj EMC (\r\027\031\021\030\036\027\027\036\036 \f\r\017\013\036\r\t\036 \024\021\ \r\036\030\f\021\017\016 \002\t\035\017 )Tj ET q 42.52 557.011 221.102 110.551 re W n q /GS0 gs 221.1023475 0 0 110.6712149 42.5196833 556.8905423 cm /Im0 Do Q Q q /GS0 gs 221.1023475 0 0 116.9129653 42.5196833 438.0976036 cm /Im1 Do Q q 42.52 316.996 221.102 119.036 re W n q /GS0 gs 221.1023475 0 0 119.073581 42.5196833 316.9584443 cm /Im2 Do Q Q BT 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.06 Tw 9 0 0 9 42.5197 306.1958 Tm (\022\t\217\210\b\002\220 1.)Tj 0 0 0 1 k /GS1 gs /T1_3 1 Tf ( \230\212\214\221\215 \033\026\203\025\031\021\024\026 \t)Tj /Span<>> BDC ( )Tj EMC (\032\031\203\025\030\025\027\n\003 \t\027\025\211\026 \033\n\t\023\031 \027\ \020)Tj 0 Tw (-)Tj 0 -1.2 TD (\033\n\023\021\031\021\025\002 \035\220)Tj /Span<>> BDC ( )Tj EMC (+)Tj /Span<>> BDC ( )Tj EMC (\207\240:)Tj 0.211 Tw T* (\201\) \230\212\214\221\215 \030\n)Tj /Span<>> BDC ( )Tj EMC (\n\033\031\032\026\203\025\025: \(1\))Tj /Span<>> BDC ( )Tj EMC (\227 \024\032\026\021\t\t\f\025\021\013\024\031\032\021\020\017 \t\027\025\ \211 )Tj 0.143 Tw T* (\033\032\002\003\n\017 \013\025\001\013\025, \033\032\n\004\n\030\002\211\ \025\017 \006\031\032\031\016 \033\n\027\031\032\004\021\n\t\024\021\205\ \007 \033\n\032\203\025\007 )Tj 0 Tw T* (\021\026\032\205\204\021\n\202\n \t\f\025\021\013\024\031\032\026)Tj 0.013 Tw T* (\213\) \230\212\214\221\215 30 \030\031\021\022: \(1\))Tj /Span<>> BDC ( )Tj EMC (\227 \t\027\025\211\031\033\n\030\n\005\021\020\017 \024\002\204 \033\n\t\ \023\031 \023\026\016\031\032)Tj 0 Tw (-)Tj 0.21 Tw T* (\021\n\017 \024\031\032\003\n\013\n\026\202\205\023\002\203\025\025; \(2\ \))Tj /Span<>> BDC ( )Tj EMC (\227 \016\n\021\026 \033\031\032\031\027\002\016\013\025 \t\027\025\211\031\ \027\n\202\n )Tj 0 Tw T* (\004\n\030\026 \027)Tj /Span<>> BDC ( )Tj EMC (\003\031\204\t\f\025\021\013\024\031\032\021\n\003 \033\032\n\t\024\032\026\ \021\t\024\027\031.)Tj 0.024 Tw T* (\216\) 3D \230\212\214\221\215 60 \030\031\021\022: \(1\))Tj /Span<>> BDC ( )Tj EMC (\227 \024\032\026\021\t\t\f\025\021\013\024\031\032\021\020\017 \t\027\025\ \211 \033\032\002)Tj 0 Tw (-)Tj 0.109 Tw T* [(\003\n\017 )0.5(\013\025\001\013\025, )0.5(\033\032\n\004\n\030\002\211\025\017 )0.5(\006\031\032\031\016 )0.5(\033\n\027\031\032\004\021\n\t\024\021\205\007 )0.5(\033\n\032\203\025\007 )0.5(\021\026)]TJ 0 Tw (-)Tj T* (\032\205\204\021\n\202\n \t\f\025\021\013\024\031\032\026 \(\032\031\203\ \025\030\025\027 \t\027\025\211\026\).)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.016 Tw T* [(F)-16(igure 1)47(.)]TJ 0 0 0 1 k /GS1 gs /T1_3 1 Tf [( Endorectal ultrasound navig)12(ation of a patient with a )]TJ 0 Tw T* [(recur)-15.9(rence of the \233stula af)-45.8(ter LC)]TJ /Span<>> BDC ( )Tj EMC (+)Tj /Span<>> BDC ( )Tj EMC [(LIFT)79.1(:)]TJ 0.207 Tw T* [(\201\) Endorectal ultrasound navig)12(ation before surg)12(er)-42.9(y)12(: \(1\))]TJ /Span<>> BDC ( )Tj EMC (\227 )Tj 0.193 Tw T* [(transsphincter)-36.9(ic anal \233stula, passing through the super\233cial )]TJ 0 Tw T* [(por)-40(tion of the e)-14.8(xter)-14(nal sphincter)]TJ 0.006 Tw T* [(\213\) Endorectal ultrasound navig)12(ation 30 d)26(ay)12(: \(1\))]TJ /Span<>> BDC ( )Tj EMC [(\227 \233stula-lik)17.1(e )]TJ 0.029 Tw T* [(cord af)-46(ter laser coagulation; \(2\))]TJ /Span<>> BDC ( )Tj EMC [(\227 zone of lig)12(ation of the \233s)]TJ 0 Tw (-)Tj T* [(tula tract in the intersphincter)-36.7(ic space.)]TJ 0.074 Tw T* [(\216\) 3D )0.5(endorectal )0.5(ultrasound )0.5(navig)12(ation )0.5(60 d)26(ay)12(: \(1\))]TJ /Span<>> BDC ( )Tj EMC 20.969 0 Td (\227 trans)Tj 0 Tw (-)Tj 0.006 Tw -20.969 -1.2 Td [(sphincter)-36.9(ic anal \233stula, passing through the super\233cial )0.5(por)-40(tion )]TJ 0 Tw T* [(of the e)-14.9(xter)-14(nal sphincter \(\233stula recur)-15.7(rence\).)]TJ ET q 274.961 559.407 221.102 107.716 re W n q /GS0 gs 223.5797094 0 0 107.7165334 273.7219601 559.4069282 cm /Im3 Do Q Q q 274.961 445.874 221.102 111.532 re W n q /GS0 gs 221.1023475 0 0 111.6314771 274.9606228 445.7755103 cm /Im4 Do Q Q BT 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 10 0 0 10 496.063 445.8746 Tm ( )Tj ET q 274.961 327.796 221.102 116.078 re W n q 221.1023475 0 0 116.1927694 274.9606228 327.6818306 cm /Im5 Do Q Q BT /T1_2 1 Tf 10 0 0 10 496.063 327.7959 Tm ( )Tj -0.021 Tw 9 0 0 9 274.9606 316.9959 Tm (\022\t\217\210\b\002\220 2.)Tj 0 0 0 1 k /GS1 gs /T1_3 1 Tf ( \230\212\214\221\215)Tj /Span<>> BDC ( )Tj EMC (\227 \033\026\203\025\031\021\024\026 \033\n\t\023\031 \023\025\013\027\025\ \030\026\203\025\025 \t\027\025\211\031\027\n)Tj 0 Tw (-)Tj T* (\202\n \004\n\030\026 \003\031\024\n\030\n\003 \035\220)Tj /Span<>> BDC ( )Tj EMC (+)Tj /Span<>> BDC ( )Tj EMC (\207\240:)Tj 0.167 Tw T* (\201\) \230\212\214\221\215 \030\n)Tj /Span<>> BDC ( )Tj EMC (\n\033\031\032\026\203\025\025: \(1\))Tj /Span<>> BDC ( )Tj EMC (\227 \027\021\205\024\032\031\021\021\031\031 \t\027\025\211\031\027\n\031\ \n\024)Tj 0 Tw (-)Tj 0.131 Tw T* (\027\031\032\t\024\025\031; \(2\))Tj /Span<>> BDC ( )Tj EMC (\227 \024\032\026\021\t\t\f\025\021\013\024\031\032\021\020\017 \t\027\025\ \211 \033\032\002\003\n\017 \013\025\001\013\025, )Tj -0.026 Tw T* [(\033\032\n\004\n\030\002\211\025\017 )0.6(\006\031\032\031\016 )0.6(\202\023\205\005\n\013\205\007 )0.6(\033\n\032\203\025\007 )0.6(\021\026\032\205\204\021\n\202\n )0.6(\t\f\025\021\013\024\031\032\026; )]TJ 0 Tw T* (\(3\))Tj /Span<>> BDC ( )Tj EMC (\227 \021\026\032\205\204\021\n\031 \t\027\025\211\031\027\n\031 \n\024\027\ \031\032\t\024\025\031.)Tj 0.012 Tw T* (\213\) \230\212\214\221\215 30 \030\031\021\022: \(1\))Tj /Span<>> BDC ( )Tj EMC (\227 \t\027\025\211\031\033\n\030\n\005\021\020\017 \024\002\204 \027)Tj /Span<>> BDC ( )Tj EMC (\016\n\021\031 \032\026\021\031\031 )Tj 0 Tw T* (\n\033\032\031\030\031\023\002\031\003\n\202\n \t\027\025\211\026 \033\n\ \t\023\031 \023\026\016\031\032\021\n\017 \013\n\026\202\205\023\002\203\ \025\025.)Tj 0.012 Tw T* (\216\) \230\212\214\221\215 60 \030\031\021\022: \(1\))Tj /Span<>> BDC ( )Tj EMC (\227 \027\021\205\024\032\031\021\021\025\017 \t\f\025\021\013\024\031\032\ ; \(2\))Tj /Span<>> BDC ( )Tj EMC (\227 \023\n)Tj 0 Tw (-)Tj 0.11 Tw T* [(\013\026\023\022\021\020\031 )0.5(\032\205\005\203\n\027\020\031 )0.5(\025\016\003\031\021\031\021\025\002 )0.5(\027)]TJ /Span<>> BDC ( )Tj EMC 13.536 0 Td [(\016\n\021\031 )0.5(\032\026\021\031\031 )0.5(\n\033\032\031\030\031\023\002\031\003\n\202\n )]TJ 0 Tw -13.536 -1.2 Td (\t\027\025\211\026; \(3\))Tj /Span<>> BDC ( )Tj EMC (\227 \021\026\032\205\204\021\020\017 \026\021\026\023\022\021\020\017 \t\ \f\025\021\013\024\031\032)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.075 Tw T* [(F)-16(igure 2)16(.)]TJ 0 0 0 1 k /GS1 gs /T1_3 1 Tf [( Endorectal ultrasound navig)12.1(ation of a patient af)-46(ter )]TJ 0 Tw T* (LC)Tj /Span<>> BDC ( )Tj EMC (+)Tj /Span<>> BDC ( )Tj EMC [(LIFT)79.1(:)]TJ 0.207 Tw T* [(\201\) Endorectal ultrasound navig)12(ation before surg)12(er)-42.9(y)12(: \(1\))]TJ /Span<>> BDC ( )Tj EMC (\227 )Tj 0.129 Tw T* [(inter)-13.9(nal \233stula opening; \(2\))]TJ /Span<>> BDC ( )Tj EMC [(\227 transsphincter)-36.9(ic anal \233stula, )]TJ 0.187 Tw T* [(passing )0.5(through )0.5(the )0.5(deep )0.5(por)-40(tion )0.5(of )0.5(the )0.5(e)-15(xter)-14(nal )0.5(sphincter; )]TJ 0 Tw T* (\(3\))Tj /Span<>> BDC ( )Tj EMC [(\227 e)-14.9(xter)-14(nal \233stula opening.)]TJ 0.006 Tw T* [(\213\) Endorectal ultrasound navig)12(ation 30 d)26(ay)12(: \(1\))]TJ /Span<>> BDC ( )Tj EMC [(\227 \233stula-lik)17.1(e )]TJ 0.074 Tw T* [(mass in the area of a p)46(reviously de\233ned \233stula af)-46(ter laser co)]TJ 0 Tw (-)Tj T* (agulation.)Tj 0.137 Tw T* [(\216\) Endorectal ultrasound navig)12(ation 60 d)26(ay)12(: \(1\))]TJ /Span<>> BDC ( )Tj EMC [(\227 inter)-13.9(nal )]TJ 0.126 Tw T* (sphincter; \(2\))Tj /Span<>> BDC ( )Tj EMC [(\227 local scar)-15.9(r)-37(ing in the area of the p)46(reviously )]TJ 0 Tw T* (de\233ned \233stula; \(3\))Tj /Span<>> BDC ( )Tj EMC [(\227 e)-14.8(xter)-14(nal sphincter)]TJ ET 1 0.68 0 0.12 k /GS0 gs 42.52 557.011 21.907 21.907 re f BT 0 0 0 0 k /T1_2 1 Tf 11 0 0 11 50.2666 563.9766 Tm (\032)Tj ET 1 0.68 0 0.12 k 274.961 559.406 21.907 21.907 re f BT 0 0 0 0 k /T1_2 1 Tf 11 0 0 11 282.7075 566.3719 Tm (\032)Tj ET 1 0.68 0 0.12 k 42.52 316.996 21.907 21.907 re f BT 0 0 0 0 k /T1_2 1 Tf 11 0 0 11 50.2666 323.9615 Tm (\026)Tj ET 1 0.68 0 0.12 k 274.961 327.796 21.907 21.907 re f BT 0 0 0 0 k /T1_2 1 Tf 11 0 0 11 282.7075 334.7615 Tm (\026)Tj ET 1 0.68 0 0.12 k 42.52 438.032 21.907 21.907 re f BT 0 0 0 0 k /T1_2 1 Tf 11 0 0 11 50.2721 444.998 Tm (\225)Tj ET 1 0.68 0 0.12 k 274.961 445.876 21.907 21.907 re f BT 0 0 0 0 k /T1_2 1 Tf 11 0 0 11 282.7131 452.8415 Tm (\225)Tj ET 0 1 1 0 K 1.5 w 4 M q 1 0 0 1 411.65 534.1758 cm 0 0 m 40.295 0 l S Q 0 1 1 0 k q 1 0 0 1 405.4567 534.1758 cm 0 0 m 8.966 -3.262 l 8.966 3.266 l h f Q BT 0 0 0 0 k /T1_2 1 Tf 13 0 0 13 459.4961 529.9819 Tm (1)Tj -27.889 -1.523 Td (1)Tj 25.425 10.704 Td (1)Tj -25.005 -22.482 Td (1)Tj 2.284 13.186 Td (2)Tj 19.886 7.619 Td (2)Tj -3.227 1.754 Td (3)Tj 1 0.68 0 0.12 k /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\033\030\031\030\213\b)-20.9(\035\231\213\233\t \021\032)50(\b)42(\032\231\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj /T1_4 1 Tf 25 0 0 25 512.8268 56.0378 Tm (63)Tj ET endstream endobj 1925 0 obj <>stream Adobed     '$''''$25552;;;;;;;;;;   ####''',,,   ####''',,,   ####''',,,""  !1"AQa2Br#Rq$b %&'()*3456789:CDEFGHIJSTUVWXYZcdefghijstuvwxyz!1"AQaq2RB 3 #$%&'()*456789:CDEFGHIJSTUVWXYZbcdefghijrstuvwxyz?A,Q9ΔVF;hXe#(6s29Hȇ'e=Hz]߻\\= ڥ#j{}yоv6% ̪>.9=zgsrK\DoP;Ro&íOY#\ְp5<,4-3c@;%nY;{3[p}Hޝj'ɌA9vSOL}lfސߣmmSm%<2D[YJO\*<q)wZܗbMΓ>FLzֲ[{v|oC>ͺ-11bdUzkorf6XA%$RfņJz9]KC{5+Zl_Kn6d,6w2ȫ` 2e o/hVpȩZMǴ2uEoEn1L֤ܔmNF6ͧ\k}cNHuIpZ[dN3ĦߣSS } .O e+-jSɷGoOAuN^̿U9iN{eT|IZz!OWںNܐߓ'k 2كݒ+=]2j.Ӊɯ~w [#KQG4e2ͼhtSɜxUjk4}ӱ8~22GƓ!)>F8!3y[v*:ܶX]! 7V` jjkO v6 i~Gv;vukuhs֕ufz+)q rTOc FL(Lfte#[㫭c|:BUkGN䇳H]/f]ؼ7γ8J !:~њ!(Et$al%F6 ]Lv:ZeNpipgH>[NHnoJ`Z7YzGS^;aُsC pNZ<٬puTNj^zM2V~/"hmL56lMwjnrIaQ |{<8vSS[NŽc9on^;ukG[M贿7 x_5FAz. iB{A2,C5\!eae)>TqxEUq?Pܾzqt&?i坔hoWRMG!P5SJۊZ]Hdf .(=edez:}ֵ/Kϳ58,^iЭm&K}T*0Fj"sM5UjiW`7~=;!.P^Զw{{ݼ6w>~CS8uc*d HVJaEBK2\Е[r#H՛>vPev;hU \«5TFrc#NV.Ϡ=UڢM?"vzͽ?v}#nl2jC][(62 vh$()MBdU5VhɌeVл=l&\7خVcn>Fe:R4GMؾv/Eoeٙ)M|F)HN4AAGUTJrmɲy+Ok?kLcaO@b%9n/gY;;}^Vi^܄ M3x H5Hޭ¶̳I6NKIslFvŭSdVƹܧF@Z4ۜ{'\I^dMp_`%IRv͆?=ñH'8I=[bEEzG]H ^6e,|-c å?8':+ 9<~Oq0܎b1{5l؏\w'^Oz.ۻWf&9&bGWǴ6Ai uK#sO,l*NYqɸ#[Q+kƵu.ղNf|1~~ FiO =#sGt[ 㬗f᤻|]$ɼH۔&yT()Q.Άo.=2T9vd~ >>e5R-sںO+Y Ohߔ{.7;Q׼[.)k|[j=ac[^y 'f1gΪwNSUc̗._Ʊ>3?fv>$hKݭmD{a]F=!VSh-M!)E99BMh7=mԣ7šCtuV[#x.{ܘ/?Ff֝;:;f#ߙ笳-8KA^$2-h6!MMsVmm<]K@dz30yk 2|G:n#vksM7k0n|c &H: a(ĺ/OڗvpƍamN%.W&[]q g-c͋)G7;$. 쟮F1 漢Gw{fُJ;OjGv;*9'Ѵqbl4 fvzɞ+㮧ol%r݇{s%{9m;ٜ K;H.8Ddk-P)guMC\Nvq]MMsfܐ$qYt},I{S[DW/!r>i~za煳 e ^ k2^kk#=[QΡ.;$ɗgk?;vʝ0Z:~iIGIOj{^qhN}TKH-kj0IռCU]:פB-0۹{&=3zd$ּf}'9kf!Ri5dL;-.c1h.WՆ܁cΧq? 7aɻ2/Z?6~E%!}2:$Z5w ؏bx9t\bƗnٌBSc(E脒aIiޚtvyTJhORO,i: wlUR񩬽z?Wa]{l=nf]gu;zkXG6Pq$ $j 8-L\ p(53BX[$o~*eEcv}Ϲ?YDϵK%c{7<C<{tjI_ڻI[p:uND. lW:nfwsn54u(DZ,5bl.e4A܁7g=q$|Vx{ ߠRRղO"WŘdI%Z;eܞf;J{p#) h"YKx4;r)զa:I$0/٩ V-6'a6_$I%W_2/5R=McKvy-ZncۍFUPfj)sxMd#m@ֶ'% vkèPJ*:`n< 4 ѺN uѝ˱˳'Sxx*'۽oBU\B]O8Zmn-)FNwl Z×/67c GoQ@?<.is?rl8=GRIcnNH{)N-HۆX3)`>,V8)csΕ}~ voܔv){rFG'? {vc-QRv!Jlrvn}7TC콦= :\kH7-CDͨVx_`6;1rw⺡ ũ'iiCfzgc秷wѰuMkkmcsُ]Qδw7{njOx:~sZTlC湴zU5#X69&<*ȫz\cYhG"RfK4$YyuNh{]qw'( G>jh-S GgNs+t81}'w^T-t[HJPN#ƚzɤ{7uXK&,s+9prz.ê3Wٙn{ Foi'/٭ܻ'`4ۛ&"HjNP!7Rc\fM3N47 lMi9çUGLΦ@8F7QC/-J7@ĺn6cA[|=Q=ۦmjg7x:dZ_(89U곩|6w{S݀n0_Yxq)ϞaFv1|a.d!)[jb##k`dm«t<㙾Yfǒ˫֣gɽNnHF>iA#=SwV{׋7q"M Ssӻ},%/Q'5(9蜽Y5ȥZ| }7!){'{ѹ^TifEݹ0d,%uN!|k b~[//HӬdBV!651F5>)(=[WNهײHˆz,`J,EtIo].އ2!xtݴCq h7v.UƓ`,x*AgVvv;sܚ."=/ߵ ;HO\fܫk)Gn2c^p+B21VjBR/]DVOvHs;kFgoQ˭Q_GvOr/RTg9<ƒۨ: lmbsfh6'4o*/zcf2EJ?nu=#-_xm+~K{{atPݛ˧j0AញHMijksٻ\7w^ 雽 DyeZòv[sۧu;v'`*|]\V* ]&}D:^sƏs~5=oԥ"07=fnA1IQ@߅%`)Nn%:MMoaځHD|wgws{lOY.Kϴ;Odi= JN:S]nXJ?+9k1ٻO)0¼N4hece][nͯv$]{?#*ܗTVn{.:8#@A1HA qYl*Zd{3,ގ\@qs@Q 9楅І?7E(xN^zN~nUWEKgͷ?W׷#b=k0ӕ;}.xMqoȝ1c`O~*6Ric6cd..n_mi#<CS\7;,;RKN{]'᜙FD)mk?v.-me;CͧGJkovYU|c=A> #X hVGi͏PTHT馆#srB.X7:ZAYY]mw;?idi6=[qa=P4F1ǻ=2;]yB55̩cHi,Щ.!;ц8Ê4v@UMMk{Gg0w{4w G2:S͕n=vB[{ӕFM̠~ bNlݛ FJivLfV!85ZАԍ n9b*R܎>e'ˬN=K#p[?SN= ٶΧhͶj& `:b:f.rW^k3 uoS|5vm:bQ>H|lt8Tcfް.pnVԔJ ~.sPCxHHv ɕQ?i<Ǯ_qgY.׵;U݊]߷I=cT"ꮹqo|{[ߕ |=}{ػ{D=VĝxcМqh dH{N%:7{y~E v(uR_~:Gh٧| ,)N>?vsѰkf$o9ookj+緸ɓxh+[F}$Xأ,Dk%ެtP29ٹ,'RS؜Y.}zh/6yC:ΏF;la=aMe(!(݆A9vǪ>R4r]qm}Һ6wX解zQ;mt[^.]f2)Hbghc;kcBAc{EJKtP5`lX\\pxLoA%55d{Rw#:a}"Y(ͯn<˴W v1'w7$WƯb< s&q:ǁ1jB.Mb˳Ag9#m O4ݾϱN"$O+i}nAM͟J{}ދ-NlJ}zY$K }.r MT=}{a*| )Ҕc~I#Ėia'Ak*Qjj9c'/j2u{]"}It~QσD'Su nfȵ46c>2bogm. Wx 9:s|*)m&VګKҡBnT1F;EFy}j}#Y^k}?[.Y7j Z؏j anG[okpj[쟠W˭Nw$ƍaGKiz.p^kwknԳ$Xmk"G I,Ύske.ӹP{hSr&I+vInnr#N7Kv}D3=AE&VAEY7L'1f^1[Vβnv4템a'*b宊V]}vJ?j}O[kn\4Sa]t n˫iٗfb(3@]]>qiY6Ym'4S'u|jSg7 Ch(\tƴ9)6pk/s'e|mMd[ip:W4haChpºalRYb@0?allK$u8^x}@ki56d3)fwhz7Z@}j9K2ƌit Ă#E8;,Yɷ"#f>c8N\+TSᑮ'UC1lvkEIO,v%zݚևǺmݿe'E|_~'RH.c~]o1ދ{k)|d,/O%>c-O<':kL[nXapVjgBzk]l%]}-Izoҽr'j.Ԍ<ƌq^͹1=L>{&v;o /LVJEMMEY;ԯXE\jVc}s_η^̽Nnwؽ ڄ!(q-:/[?G }wYڗEWG@ 2Jj} QMi:mϳ ڶˬ浤?3}aƺLkV&2sGZ\ri=I9.d'$2WZ6鍩J3ٱ ܌nVU9s/7:ńd%8 aƝqp U|쾁لekaW[btXݧ;rǪK 6'J]idH)8alum==Pb2٬]Y{>LH"<|{;][g zT_J/L-Ƙe&p5KXk*MV(X/k.׻Hhw ߌnm»ݔUiXKm.T\8U!;h3OfeDS|Rʹgd)g-d{Vچ)m$TKS66am ܞeNkhݟު][ +"uZȎRt 8-mku;:"XoG۾vr47\>t}b.^IgE4k:숧PTùJLy 6>ˎp6\9[Z#7흫یaOL"F?}cmD o$^O_Jvm[7]YϞގ]k!<0nN++r2<_F /ƯN^"'6#CLx4[? e(bcTl< AaIS^Ƈr$K#~z7?"kZ~Y=XRܝ>8-nRyԽwO~Xޚ%Ò5nv] tOvK٧X>T؈+',3<)o;WZjdoJےc#jZz >. 2j1SpL1PhN"y@ $ 6RwvGƁhFrU/H\v.hw#(:~?T6=h.F؅pi<̭mYl iQר-LO }-j;_|naY"h~hۃlS˛4L;'Lb >bcb!d#F,+kCml#DuV6/C_)Q6`7L: M]&Ԗq 8S~/}"4F u7l19и7;!uRA;oxY uJA7 +붅D]v8XByԭ#"l-sli!C~*u<5|qܷvDE$z|orffm|,v]Gl+&]|:vlw^6+\tk[g'BPQeNsqڧ][En{_21wG6]-ν;\'foS=OeK&+]Gi,? n<>Lk%OD0d9sy֯]q͢ z-KU.̗suڜw&|7ҏm GqOqKԛY37fm*]貚͏JWglvmeh7kbu>< |m\!{wA= jW0q'@\NF,C Zvl>ȯ>vxg Ej>Js;{;pbEۄ!JUWӏQ&X-n{c&#j]pUXn7,,nyL37vv,Tíc߃-@kG'7x"ڇSSYϚMɒrǁBy!ƩBoIFgE+hz bvL.ͽ͹Gzf!M\Wj{gݾۡQ%a!Ѵ:j:;2}6ذyz jl4Y<Ω=BیWA:bD_!/Cmm̻D6$:D ֘Ai܎%;d0Jdxk[;GD%{5zSwov2rCϵF=.5}{t}-&7,n)ÝT2wnӥ=ɯ_'5zz2al>|ڋө>Ժ[-e&q') :hñ{pSY쳓yq^n݌oI/EH>U;NoQ!66$\6' #[ lʨ]T zm:fW?7 Gm/ {5-INȏ<ŴYwc&OȾD l7^= vݽ/{<7`^I|#;<ƨ 'ow"KzRrpa_*R+E&H; 'P FfmCA^2&]^ 2ez/v}=|VUԔѴ9pauJ3i: ee<=c6clmo&">uMPA=ƭWjz }Mm{f˶.k kfD) h~f\fELxy8}Wp^:CQ3aWx@*j9#ڗ]dns1cWghGnd]}K{&OGv;[PYc`Gh 'Zv%-Ypse3lPJEVZ3#KKWM1XUM߇ѭִ[PvNvWD>,}׬^Vā=ԫݩ>nl܌BY(gmoM'c>H22gLK6a(kј6j]̑('8,zZ+Խk7;H>E}&POհuAmm:8kFSknmS|nkc 2hc7ӽY]fϥm h^4`.B e:T=ڞJQM}tT}P~Cӱ٦lunxnR'-?omDCKZ uJM# XYpj G&fjNک =nԬ[zرJ9ۂW[k7{&hiip%,DO1g# )`6*.r7VIEdnlmcz6ӹGGlO]I3v{6'ԝTjvj߆"f5^Ƴuխ$a}v,˚jqXrdIv|Z>uƵD{نrNΰavw z = }΋k^2ۜ}̎7Ter@P./6THp̨'>c@Zk&w;lFW.zuݟ[ͷ<"^>MfCIv❴mXtNAUkZڎS'W{N>n~Wz쾂w6F0ܟ5Г؄YJyg>;JɐvvH~y8Y ˗Tn1zde՞@NN#>08T<ص@4M 4t{<vq[I5)#{qd;rlTXWw(J_13N Uf:ӥedp6VMqY>\SKQޜ6r^5(Ǫ'ܱ֟b㦦cST l1@-MT{Glӻ =@ܞ~u$c'̓_KW# Fs}ڃc'V6%-j=&q}orQW7{d'U /zoM6_1fKsp2SM{Dg(FN{TFi{Љ/= ٢a>/?&|tUOt$\NC Wވ_+u;Gpfk33{u-R~).H @T>?LB2ڞ>t vvKlmg 5K6Md 7k8ZHYk䫆8\؅Ʊ[2ů]S\7vӻ7nmvK~ۗy`"';z?=ovŷ [Kz3ǫ7^5Wԉzil, $Z}r576VmmR`ke7+ObqU37%] yT{Ť46k͟DhucloI7$WkA ؙuݍcEgb^|踫:stNLF(  c]ZǍsЋzv}%J! kww$ｎl(:ѭT9Λ֖[x^`bOLqt~ua*ݾ,сp1k}JG\W/B6/s%D;H .ڗ?.,-tLI(uL%MKlHuJ{t~GT|[m8KiYpp,ڻJ;Yg;AגgBw$ cI/7:;Jpڷ6}q&>0:Wn;b.8)y&,,}<{%rFw ;w *jkMw<ӎ%=y|9קl>=gm>~DGZ f04a!dfЂQr_u SP wT5wU^ǰv}ou1G٥%}ewOzq>MevF::OL&Zm!l#[+{wV2J=1_=m-oϳݖOYCbQ̚[zQ;Bn5&jGЕ!a˚Vm{/WZѲ|I¾L>kxnilJT-ջċkEs@r QW\Y9ءFqܢ*WO;5ZO@H<#}S{ ﾰ/zv mJ;{3w+h5g bx~GZ?YǺ="u4[,3ΦX2{46q5Rc4ӾZivɆN)k2? 1k{&;p~Z{NV%~Ƿ}]QZCvcj6yCu,7'0ZMsD@E褆X2۫ksoQ9DL2]#㮃oozP}NŸZ^ӵg b8u6P7*\ۃ+!lqi{ޓ̣SF wX.UG,rXߊjh#wǹ9}nsս(mfjƷ[}cʏ>H>h)-f~!׍\ P7*ڇθ%M`ޗ;_E5wv{>;~zLkG[FMDIn vvKfFdH}\^ru*úHdux,cljh MJJ q#Xףz?v_G;;'EݥZ֫66GM}g3xGPL3jnj~c>1CB:v0W- Wiڔ Jx{?ھzGnNܻ簘9d\\ejƫZNջ;VDF(M=InFoCsӳJ2U#}?&>zi&Rd*ď6*jkE߱#zOoz}3Y[1#)Bekg67qRg #2;oLxԉfM/N3Q M^Ml6z>1bRk#n{;ӹεXE*6<:'<*v;>IکC]S%vJuGtNQρ"JVLqPΥ|5pۃ,}HimtttCթ$(ѽdSt#`ͯ0φv .5=nKw%Na>u蔬y#rZ+SXUe'cYMʥJ3w&V^2.UKMWZ(GX =GYZIC_~]hٖo/g1x[.h.lp!QdRf5svOZFO5jw+>ϋa$}>:[ZY$S+Kv9YQ?wx oyɷF[Z2Oaz?U ~xuC;PWgA&UW*D ,d=K&5Gq ޶*8+Mrp}x~ehκ-4% j~FGZF'+aC箜; US98$Zz;j1s v=דq{XtJS:c~Qַz[RFļ .em뻜̆]g?gcf~;?e{D:6TW\dw2y7gz^.\k>,fIWII/ٍVGgnVʚfFU}梨zjC^QrX@5C}o8iƐ{0i n"9S]n ?Ok{q5eon2ygka;FЯn}ރh$u(hv;C _97SJ0:88vѪM핚hc闱l[f콳r[voɮ_?jߜI>7z7blн\o'Nu}cv}޸ژc4& #lOsdonӀrhآ_#L9\7^N nHU |U>c)y8HV?K[ ;\ΘU≭fe}jf}@ {nCġ SSZm'zLTM{4!(<{;r[}IΘvX-19εM#Z]Vyc^A8Œs#-mzK,Q5흻kzgbd/ݬ7J1a=.r;>V޺OGfaC E nXN!cȨnOwc: s*[ɳ/gt&k{\{dc(nKwl[v}Jf3D4s No):{I/eg߈oL>^e5>+edt0C@D6ʧ&jo3U{,#o2CV}k7ig{;2zk{+z6Zf.{΁JA;INi4X3[ʭ݁.s+kaSZ')<#AKsMڤsxӾdܜڏ mٵ5L8.49TlH@eq9ѠF\׎sXjj\TM "S4~=n"ԟG]==ݹOw fżkgkel"5_G[Gmmqd=cJZ*+]oˏflJUe/߰ݟZܲd8Eb ٶF/_ :F'bK:rS.@y6VKwj巶M D8ƣ ~LIS p'RSJuB>ơHwv菳O'zߣ%XRiTmdZ=n3HK۞݄ƍYi[+ۥnJߝL95NAp)uMܔzGrkf 7tyG*~TK$-jhv1<$k]Dٜ%Ct.ݸ7į .G\XG)qZloJ<\;xJ߳L,tSۈzd8q)M]s;Җ{ջIVt.>5z8t irn HX5wֿȏx==a;r$F[P>D/C9vrSbM^d S%izAT].vk̅/R6`UgYnf~{>̄2ʶΝ0Eْ/Rd#v_ IaZz#E55 I`{{\+s4s*7skn.u+߭?c?GqG籫byKn{7 NNXqX]dtRpsU U/R bo딯>6kv9Čp^$yz[_bٕInuMTkArq}lsE+W ߬᙭dٌ TOɉ3H\Ž\id4*WmB-G4}ڜo2ls=ϷBrWr xi0Lqf֏lo,anA֖r}ksҘM:coGy6 ;g&u7%>_73Mktc{HT9k6qk5/W K9_6k$uJ=gW]sGnG99AZWv<*:7[xG-jiŌpwFZDwϚnvw⡿鯷4&Ūmմ qҺ;@y}7ɹtPծ}La N<Ǜͮ F=zlߟg(m3Z^ޘp [jBM;$lfu"{>e2i>bLKmUsgb RvsF[?cN!0$;֏v=>k mu6[|Tc8ܬzkm lsZ`_4ڠ TsMvY6]r>) ^5 _m6kՕZ "À;U Zю@ѭ7D+jys%sà ,G&K o= _%N=n>a̦УZٷV;RU?)ٱQ9~ZӴL=%{)xEֶ)qkq&Ue/SK$)k wm{]UξZ`[DvǘɿA^N窋XƋACNyZر40\s%Yڽr<-ڨ!71@~ϯFxVLa{ۃ/Q8unIddxhJZlӢi;\J[v٫ٳ+OޔWֻj2G{tۓڶŹ?!vNmf?oa&ρ=Œ MFKSX;rXڈ=dolNQwta#nZܪ5Ѽ 7|pL"tYu[{LdJda"ȕ"c ܅#"Ka<6Y=pZl7ۮӦI=liёxνY3,$,0%qZ>.I.$isK5n:æ7Zƌdg*aMSZ{F`GvC[nn8} k1 \گӂFj.ksRˇ!Ȑ17[WKgS=y#Y;{n2+$VMfT_~Ϥ7@QG>"gT MleOcIg~HݗPvckc*wՍuU jkQڻ)9ѵzFb$ _ζ{;ִw@w<*@(oFphN_*ƱIR،~[צ^؁M&}u{;ԆFkW^$,߸ɐUyksL:] uYqnw v"kI~abH]VN.%^0x8MrH|Ξv7kiGf.ywu|~`@,WOsl4/{r,Fj~1Ө1ʥ/ #k&TN+SOTNӉ]?=)Y}2}ɠ25&ǑXΎT9UsDFOl}<֧ve\\b?mjzZvr;q}Z|"6Dݺb )$l۫i_4h/.{qW8 ͩQbKv-Qc>,nON2A(-}S>f\4]MV)D_ng(&q:zv@঴!ݗE< ~xn* . nz"Wom"x nbF}75}7qgk/sIFjd}vɯq6 H' "ZDZ-xwN xk{eKƆ~: x{x0-Mnգ"b!7VHq9HR+Z{NpT_VvXR܉%5%fCemb`s7D݊4%ٌ ICGݴ+bZ<"^}ӵ&;$zėQC[]Z=nR\N)#p&%U554#tHɇ'vDRׇ\JKyqNx]rF7k?˻D?Ke[ql1칝jrU!9 HTj`Ŭ=썬xVFJ&3i~1%֕G&澖0 :o۪ \fR qȐUI#ݾjOkly55ݞ/[1*\"u;UtٶwAT}ݭ}oky g22NʗDw8r_=Ppa`f^EvؖWFUvb CW0Q1avN(!$|U4 $>&$ߵMJa$uzw_[λ^&< ݘm !/Yޕ+Y=N"J^|v%Ue7euC{ir/R.'+&$n ֫gўLlec7h߷A=;$-T`%-WH>4%4)(iet*; hFv~7ʴLMPj1\{t|5%:t$ӀD]qZy& xƝ$)tlvlEf8I$OԑfÝ]^$kSX8٬}5^ `$OI{t)u5ܜbW\cOvq dvDlɜ>=D.@<`NnNވٿukgSX]lB$]㭌v#gĐ)Z܌YfUzv~so(RE5ᥐJjk+%穬gzOzRgKvʈ2޳лWɤy˄'KRi;wʑ5 I B$s.tOQINM#{kvE8XmIթ!s0$mtWt6wN2^h^(ɡTlWn8bJ2>CT^BP\,kp*$54-yi߅H6;We~^sd{o&uc/U"k]^{OhPbt]c(al޶vμ5{^dzc:vnqkYp) @ԕ/UZH}d [筯:7= /ON b߶կ:uU9 tH/aj[MMi&Hx~]mӮo76Gq!#1{]rSY4α$қ1 %ZdvazwbSHgG+Ȇܶyu`yH!X-ezluMز$3__[nH_l9ipk58nlsJ&=]H.Zin"lvБq<]ٮe%u HOsz RC8k8=Tm˝uO>\YHѫ}g* ioi &Kn8aw8aNU5/\ecp&F.۲w oy} ڸߘ>J$'ZlagSV ΍,.C6Uyv m17oOV|7r*4폅=0vFiRn5k}Me>mw~d?{VC9kksmL~}SA]S=4`aQ8kHHÛ)퀇3 yuZl;Wg+8}:wb4N[֝Kǧu>*JnkI{FI+]o>'flJLx}=+]w,zu鐆;1y ~KΐH~`ZO7_x]<]czҰutwsFh7#32nu"e} 9vnG[P|e>]q[};M#DyKff2Sn]NaTRWZ3| F^Sӛ,z.3ۋg՟G]vMN;MszI$8WKEɢ鬫I)|~4^$IMM t$IMMLj%Ki${)GC+֓-ĭ2tW 8ҥ9Q_?CW{$$:Br#K7IaI2u54,rۓoZ-CRWyI$CQǻP֪D}$K%)Ւf^lt}f"{$RWө_JɤNDae ^<鮑 a%_Ix='t}VeheaT}F S^kIW2GٓXsQʷi5+GP6K"iNϵ+N!_X;QoY;OLnY:j$42oMBNԲʞd:cdSSJN\/{~'~M \an+p'7h,'x?;Z` ͥD]+zFeg V蝘,s\MߟajZHZ(jilʴkM۶=E1_jmw Ƣx7,%Z%3hho#oe f%W֣sv;pU{Ƌr#D/mollMG;1 nGƛbEJVzv]PN;&z'NHnkYziZjTzi֫/یޮ~ؙ7%6BfY2rJ`\֗woWv*\|{C7%ng[~t{oB֓wogjvm|~I8ۤ4ou]Ԇ1>NJ.K;qݛwCE>ŇM&# l:!}sj2w$ \OEٖ磻6>&H8úIb"Xix8Il=A]Rcu|@p+5~>Zuz;;?RYHzYVF's.!ў߮n8^|=!"=pےcGɟYgn쾔ӿR<$^lyOڛ![&N m7 ="t Z sQ6N_.BfV;h1Lk#qwO掞ImECw1|N3Ty9gfNz6=O[ߕǣw} rMȞn5z[|&`ތ~fjz1f]4UZ-mV cnbwNNǷ@OvoKbx4,IOW]^V4ݾÿϿ:^/GRiDgw(QsL{Dײb¦rPOƙ.Mȇ 7 /-dlYw.X}U.7 -O>gqj:T{6u}lw!_P/%yꃦGI&C:)]{:ISSB$ym]1}:t:1;h4sI+fWWVTdgV[4R5㬙 |CK.*u56&Qi+KۃWzqӦI%Z]?o`*}-@BmWe9=%BIk[b˘|Cћ=ov=߅ud{mw4 ƽJ :E4׿pW1[V*J6h2 9kc0 ,-ZbbՑ'i$JjjїUf>1zi$Jjjwф/KW,ZI.9Y#I$U=]U=ZgۦN:5ƁWOWI$SSUV[Ω4qLI$M&ۢ5Up&I$ljz+nVi&)PkSULN>\GIg%wtEʷzf.d/8t \}RINMbKmSֳ?n>z@2Y)թͽ{K6~LkgҾFҺWIt Xumk7<>D|iR 'S٩h1d(/:#\&=n:d^֟i]zz|+f$*I'\%cU^:dSSUwƈ`~M$IMMR\_ @N/ԦI:dԡB}3jlA]rױYfgN+(s~4)n{/hT&/[ gn;qT@y/W endstream endobj 1926 0 obj <>stream AdobedC     '$''''$25552;;;;;;;;;;:  }!1AQ"5s#2aqBR$CS %&'()*346789:DEFGHIJTUVWXYZbcdefghijrtuvwxyz?{r;ܜ-?4k0WPV]|$N32crV J)0S q'pv# ~dS]!^ MْRzqcp(Q";[܄TŤaS;)0/PDTJPh)M&HUd}Ɠ}3EA0,-% C`)G%dulFۺ2dvkmfXJұ,vUuSՇ춛.\LDV\(9E)=%Vf9I07*#)w,U-guL8AJJ9Ez)v!Q^ba}$I:S`U^2ܭt9H8͏Γi%&Uҥ!:jbAdǛa ~Fo]PsfyHa7-dM"XM$vdB.ڮ̌ k{y\荦\Z^Oq6uEKŝdbe$udzU#v=%6 񺅥>)^lvˋiZUN؎*D%4Iǫ$J^hlNgqQfqU]@}]Nl 5q^HitЕW β[4ts 6"/$tJOaVQ4AB^5=X~cr̳. S͝f6E+{ZgsAƛasY6e2"ah7RqРLS(E@ïN,m{izMBuĢEpR5ŃۙByY-1 cN)z^W-+;ɀw7>F[ֵTEc>Å 98ӊONfi#yO8 Glc/%ªj0e7RX 5iJL%*5H٤ 8'Rx#4;`ӝa MC fJʕz%{*1CZěƳo%&pA*= 2$+>̤EZZgZf@O:8F8 #WABњ]`?4!F*#Ҡ==XZJc92+^'Lp- Wlcmou4TDzEC(dPj9 w&)wJY HhUoIi,RΒuY)4Eo (QOeHL$##ʪ(}rۏy6\qBQ<c ŠNrk kBk F0Տ  N0H6ci&8Vqxuc2G)q ʨsDU2he9Ʌ% &9',U8sRp'×w&t8D-:L6OB#օ=^/-K( N%J';)/%2O3.ࢅ >ʅEsXme\t!K(Ԕ01Ei.2T3]0Ml,8T.%R ɘZMoyʺHΜ*\s Ұ%ຜG5 \HmQ[I\1l.4B,ҕ@|)J` P8L8gHh I1Gx\ЕrMb<(Sr3![̢XBV: FJ H1"KYV+ &fh9iDӵ)NHaٕ"jR,Eo$_jZU%MO?tì9fBJ'.d 72w|:Ԅ[Ӏ[eI*uII汆Zz#DDe,yhJs+M.zcqJ<썳=51 1r-Ո $JkdPrAU10QS]8PJ(UGAǹK0Fi)7 >SXP^py yL!TG `!\9 cY@_N<1! hlɢp^ - 0R@ qX*h~ZŶEeVCI̍p}8ja< 5GDcJ mA LJӗ"&݄U u"VS .I򖬣2@A"qYpU.٩þdXwP2aVr53vYɳlKd,pEO;j~AՄ){Z$^&5W: ڒ-Q"8̪qE6ҥתb;YlRPU<R3lK*U3')f̭7VÊY3c nvpUBI-FEࠣNg@ȝ[G,:5\as:!-N츖f%Р;2G!RRMu! TG ҝP> +̒*0, 8㜄ovcBzΠo̬#UW3P];8kZÁ+Dֵ NgImTaA_KBI 8!8P)IOp@bcu 'x+de 8⺃Yj]u*لQ9-T!nQqm;6#: ʻ(Rq{y q9ҊK/Y2n{K̓Ίʾ\PqH iIB+E V ԧEs uDŽÂL4 ĈD/jRM"SoVV5x)JBBL% ֢'E:AQ$z[~aR ΐ!d(U$I!5[ kV%= Kt+X@;mFKHz~nۑCsij ()HIJAnFnיK-2P @gs-ii(@}7@ 6.5sy=\ͲdKYJjv]^~΅% 7I\LrOt89*bc;~b{{Mc=A҅+u} |U5/KYΠ"@=%ή~h@(Hх!L53DEN!E' 쎵4RŠ 8҉ɱm6t#+hnN׳eh-g֤)9\ASYG$5*0ݲIZQD5Ɋ(U*shHiCHJfsw4t8w4icaARXĒKʂu еNE1UN?+qm!?5:!XI6Sro 8u nR{y]8ɤ\Q<W&)WKn՘KekDSέF U&TyXu֍R0J dԐN0ʦݯ>9 jTU1B ݧJ %֬H[d qLA@DvHT%J Om2֜ahL0·t1WP@/H'dyRJg['}_ "ݴu2 YsIZXB\nҁ8bAlL1.˛d!ٷ 2n 5dRs s&Y}n4!+}1/xM*BO&(!R3RZ&uiMȱkI%WI*vrϖf)ʆ#vhf0B zEz-BiΊcMMJѳyUJN#0ȗR\V# [YJq'`[ j CZA5iDYtDeTT*8g&kĉkbfXMFecHBCʼOl%N\a9D) s;ˠRtC OvG  t8UZa%CNP(iϏejb]tāCEjhw [O2o&Q(!慻&jNGRh+cI#pD.̓1Tn*8p8#y4 ԎdI'YiER'm'rr=XKM5Tڃ*URʋ7s!bR\/jhɵL((!cڎY+Z:HnmQrY*JT+N^ڎH+dJ:E-D}Ly*|ǥۨq f D)ĤTV9eM"*Lzc ío%%"$f8MԈo=x慅W,aP)ӌԃii :q*ZjiN%P f UtMcfGbR'P PfaYu$]HR_x&7Ӧ qWvD{9 U3iI]ShdKU4 .*E3{Z7ymFZQYyL$]:O Mu+2Rs9he&+ ⠦+-w2OP`f(jR\e J^h"]&HH}7kHM12Nk|ͤUͥ4%FL"v~^FQ QR+0>q]fm9U&F\4LN֓-IzbY͔۔^p2/YEЀ1 @˅R)yIǶ"N-㍭ VtUԩyZf&›Ʌ#0،Ĵ”*:bγ$36 :F/4G-m }K*C)=Pˈ$0$rkdPg3g̾FM!ON M%KSf}+ ˡfd!Н5 1q[j_wnZEEBa$`BD7=k .*CffL`vy&c*ADMJ%(Lq髭:0"*Rkk ]w2roBjz!FÏ2. D4tV!MK$㪡tҐkEʕU+@BCrڼIVb AaVK qJzlZ! B*?Ks*g@tR]!24xFh[KlfߥѢD|]4B8)L+ a W+S8BsB,PMuм7ǥ4J\ ,EQ`$BZTѭDV)YIh I;"( HqBR3" iI!G %I:J֚XZZ̑8s]:h` w[)%2&g JeʚQU)9;Ny4q-D6EWcL^RSקۖ\ŸyۢYa9KZV *)a 6+AƑN0ҤJTRKi*VMC tSƝ\ zԬ]S9Q: J 1=A тgLuVqH fy(AZt1%m4Sd'VUk$IJ{<*su!,CZ3%ݻq.D48a0JDt٫ i֫7Em pKpHm<*(q{՛g*Y&ΎS&'uBjpsBЕSA(Z e)PDHal=^y2nsL+8*eLEө8`H_+|98"'$8̀F.,KYrXVp"K;VZ$LnA>͌ OiF Xq" 1! oPL 7eu @+uǬ;&`=v@ شo+7,dCK=F @rHU"ەʾ#8.m[M]:wqCjKRs,[ƑܓiE[yɒہ(YS;ZM#Hx5GBNhZ)\sC[)y#:7(bIl8/,S 90uҘ;,& I8lsBꥭ|96BB!4\+v7ք'xBN;LMqўa*V6f RRd\cD f8BЪL:D:FW:$6do Z zeQ+?#)*RpB( Xlzk:$ɖK+rBbZuUJt, ZDnj]%Ӂ3GbӮ8A~TkE'VҦASE<"uɧy j 8A\}W0(N&_&Uk-t CpV1bܞ}ę{zЕ]L+ME$\@Lm-7˻v̌ɇd S kS:0WLz:IP ƵPJC"TG⑁&E/a̛iMo arB@z@ Wq!eʈqz g BTQ4B 9SC:F1еfHBkT*3WPta%D q!R”<& X扇yJ&j8ÉHT3W4-]Кf1lr5DV*mw5h\ k0-vNi *54|oBB1j4JtԆQVsHpa% Տ rh=4z;XwcHSMI1S9H@4CeD%WY@C.CvIGKC Gǫczw(QQ좣eƒ#Dw(JT'(QQ쪣EG=W:=TzG=Tr^19Szc׌r;xǯ=|ǯcz_1=x#ՏFhcՏVp$$`:o47WMa+unzp endstream endobj 1927 0 obj <>stream Adobed     '$''''$25552;;;;;;;;;;   ####''',,,   ####''',,,   ####''',,,""   }!1A"Qaq2B$3bcr #%&'()*456789:CDEFGHIJRSTUVWXYZdefghijstuvwxyz }!1A"Qaq2BR#Cb $%&'()*3456789:DEFGHIJSTUVWXYZcdefghijrstuvwxyz?Q]%{!BJ""!B""!B""! P""!BI֖48n~! pl`$ biZhs-Avd1#"^ +Lm\N^BYocObc!v6Z@82Ȗ]! e\@ pVJ] %G)8|8gxL19 fr,Yl"5`FU*- =BkpΙYm8XzSKI$H"'ZFaszynڶsq+$uӥĺ{^fĐXEea~sPvvn~ܛMz̊!y~KᶱzD[47bH!$EXD"[c% {7`M6:`!E6Ѯ# MA'fD^+32@Bm p$l J T,AfNaUafRhD7ilI,EH=bDXE%E؇d{rx#(=0B87jzM 1"Cr#m:tlnXD7B. Io r9PڷB),\;=T$36n@q8",ȡOdv8vmpkL,"$XOdSP׋!R2MH"CAADDBLBp*e ""! P""!B!B""!B)PQ]%{!B""!B!B""!BB!BJ""!pX(LnK4SSAYsm¾i[a I 4L\v'[nx{F_m @B;PuOMQ'Dt֜]mfXY0piŎƚn=Kdzv>ڶ"")P!B""!B!B""! R!B""!B!B""! B"")B$"!TY 3z!Mv#ٔcdD6r#U,- h\} fJO1ad!HsIziBw{;,nk8^{7)vms݃A4Ǔiا {^Md+MVf7&ƀ'dUp;! -@Poysliz +|4ˠ0\%_4w8omOv.YUJDD!B!DDBJQ]%{!B""!B!B""!B""B""!B"")h. IB*ӃatI 4X"&2O mPWrsEN$q2O)VsA[ VFw{Mm**aD:;.ǂnC۹cUhf֞N*uUVksM]no{s#M:ImoO Y4޳zmgh-feh2Z}nf\3,gVy;;5@1dBɕ`eٍ)Y=X+!tݧQud,lY-"p8uYZ5t8#-sg`{^bÖ,d "0faR1 G5 p4^{ D>ϭաӱ:Z=s `H<@E_d4eE91Brzњ$@鐗wC%{GOK@]E+&K XB=lun&J p8M!כz-Vcf IC;6֕Ntk6weGew T՚Fh¹\pe(N)^JLYY {\c ?YZ=M{ot֖Xٲ@3:PE5g\=#HӛbK .*m¢fk6(]+iݵG ك̴Ҭ4uIŠ"XH"SRFEmsw!|͗o O|@kvvDZ(4R0BB si=]kl&nYPB4*xAXE$P #Ia1}W1XYZBPV30!GW+ݍi|h˥TX0mpVQe BY37StfFZܕ!YӦ-,\8j pXip*4{B#kIoHZd2UB!B""!PBQ]%{!B""!B!B""!B""!B(R"5`,&7UٚʠG[O;aZz) `ѵƀrX0YojO)XI̐\0誛fi,h+ dtF+Hf!flq=˷zд7o2'8ӭAi! EW*Nuoj@V5}mxԬZFAx:M 2{}jPY[X6+dEU=gutw<4cmu`[X +V֧[U0Ĵm;fai9)VlkKb+,E]h$ɳč /Zt]/ =*͂)6EMYߢiR]1gm^{Dzڵ}I1kmZ@0G Oh}Notmh$UUq6 -["hIsU1)1*K(7H! -k6wM&HJB/Yh;75 m2C엟Ҭ-+J i6G $E-4kP oX=g+'kii ب5$ IyugC3sIP! t[cBk1н'M: .ݽx@$Ͱ;+$0XuT^O-WQ1rn_Nmלo;kFcڴb0@.a{bs!]#+puQdcSV p!wka45e֗^$d@Gue4;Ϸc_dţt{%!¼bٱl.۹T ȴ8 ]f޳+[ss.Vqp~B?B>ܖa\@,k8aU4X.,5/c|B;%˵ЭGќ m"1W@t0blk#XU5kج..2C(O\!^qkњFW,d Z,Ӭ-*ɗcn[bHiNɛK ,lͰtnِy\ZPbE4XѬ$YXY8a1Ha+BSVգ҈vL!`Et\\ 2ȵjXq9. $!qlZ@9!tm:ì2κ Z9܄3*-tFuŖo`i;u-HV5m--.;;Fk?ܵߨ{V+KH~V<0~^5UH qBK#K=F=3Rf#0J cŘmd!vE`ֳU.ce˟"gcf515HqqK87NKd ,6΁=;}5K!C8M\2Db..4-plD+Ck7D(NGI] ,hOQ$ ˜%!QoEZֵ0b۽kA^Ȇ$fote*\N򆹼x[F1k 9kƒ h&٤6qM-uf{CZcXE1ᥦyLMG]l8Rf\#/h-c[Lw ]H6pi{L4>6^r6E&H6p- : _R-`E/t2.J EPHj<" ]li4fX_1{Wm>u9V:.ѡ=]{^Y[;X5ϱh6#O bP,茊t#%%1"/Z`[%E)-U(B]u4f=m;V4u^M\ʞmuO\& ֝wu4;AjgAs[i~LeHv5Z:\$wIcVpMDE'"vJvذ1ahNK2GI]]uKucUqƝd뭲O6x+F4 tY9t{&6M>KUn6b!q!"b,@uɼ04Ѕvٽ떞A{0iVh>Ռil}y+IU ܁$9@{%˳x617;5萵``  Z*I7셬h=Tw 1ٔ=ņ'Ӣ]fI*`NukKgC-@پюvZؠI6h,J o4 jD4l=YYoXqh&St6(H-; l \eDŽ$mm|6/{ Za$mP$fL3%UiVk*sm lvRRhMm,qwFX$+G%K^@;fBPE=6َҬu.iL-Hcj2}Sr$Y WvxSCKT hJH]2oz zǽ[_3KcuvbmMu9`H N5[lm[h+p}qʄDWRJBDD!B(BQ]%{!B""B""!B""!B!B" BĔ(*Rm IqF8VBF1):`fB s{qd7 D-֞m֬YXN[`.c^\*%"VWu]n&{܃+ad,2s'RNj1hȘDh I6[D*/:޲س؝el&=tRBYho7Pg !lb О`n'eOY}k4Y6`u*ktNXdLodB#4b#s1U(+-zӳ흴'8!Kt=ibm﫼] 4䘉nD!pGZxOu,HAVb +(]JM$[V0fQ39(BHCl[08^1cq:{!p6]Ɯ9FoPrVqG!pXβXjC-Co B'WGH!rXNŁ(&̝AS#EmW䕑#@!sd4h)cuKH  euhYX*;m< " nlæņEY vX3Fז)֜6RS4 }]r:H# ҋɳ&̵ʽp %KL 8GJ=ϝ^/ٞJn2.áڷU2#\U*ʤ-W#{aL:Vs]b!-*(툵o1+lai7C |zӁ3ظlє/ZuuweKij>(U ^'^V&i DN45̈0F'QdXnnp~BIӘo1N\+sm};F7mZa/Y}l 'E 4wttѵii"xKK\CqMLYV+^>$ԋddq]z0ȑ VԬq`dkm\ӴOuzH,t/,w؛[PgSHs}5J⻶/6:be!:|cjcj3mZtEd(0^֫[Hh\$N5Jkr/B ePLgxm]Jhc#Y\sfKNNFi{=`{7)GqE+GPŶG" hXcꆓvrs(2@3 MRl^ h=jhk A ^-ų851W!J^ui.xhmh͎`R777*\ddŹ`iqNApmꚘm91m]hq[qA hiRgE4-!]e`0Eb ^3޽[ZEt.%DȑMp;לўt~mm Z8ŀ N ke#V' u4V7k1]Sa0TݼB3. Bl # L<9`(Bߣi}xu{ ,, xpsZ4 :La%X te3׍rzebmbVZ{ʫOYvl6oe &֎-sk +/G klZDf!-0oҀUvt[Zh]uds0vCah09nfbܧrZM/884i¢gttvuMkh al;RWh)P"!B!B"" T Q]%{!B)B""!B"" "!B LKZ\CEI0”*hO"nkYGtHQXn,sn"l^ \Hx,2q{Z3 @+ΐ  JXTB`i2W#Yi@e\pH2Ӝͯ =<^;7`=֥Ʈ.%!f'ZQv4 H`5XB`QuO]QHëT3ZÉV!9G>Ҳؑ] '\K3-juKn>E8eEwmx&V0bvWx%t4==^m-BY qЄ#F-,총tf7G,'oӎ GģV##4ZK+ ֙2%|H1p+Ӏ )*Vit=%msm4w%AhӰGG-Gxst @ֺdB2:Z(GZp #tDFJ \nLЅƑn1!]O@a~J,>ڱHw$Y4-)s].6^jjUr/qc`Rm+')n _i`HfO=h7PYpZM"4|ȵdLr[Sd2&'HCLgdv3B%zo&̘"^hFi="gkgV׶va{f`^f;#\' ݅vWlT\yqJ֊:  k#R-,%7< gi  K&$7dn,Ng98,/}dBpqea8c= 8ӠJP/4k뼶z*Z3k +=zS_zmG4IÞx{j,x H!gWHRDx9}^&207ŭ1G9J%|M ЗYe*Ӭ} GLÑvڍK'¥DEAu>^iD=M"3\e#RmZȾf ѫ5 BaVCXZD4­xK딸],ȑuurK:6 &&$0+gi,+v6`†䴍" q%N ݀^j P 458 v}h4u9,kY}Pе [ce0gxÔ#ڱ-IvUm\flX fc(%e8L ȴ! vm/iW3s,ɨ'<l4õ5H vXXZ+Y4ScKxq5;UbpbɁ(ɻ)mR< $ p-]>}l+; אYֳK4{+'j`&YbKe[z=lgjnENyAgjuE:\ `7r.c(Bh75Ьxs}ڱeEql]bތ%}7@;E+o]v@{W "36K1(!SGfdpU:Vg`'u&w*]J0R)DDB!BDD! Q]%{!BB!B""!BMtbXր0]oPFey9T 4n6b , +fi1WA(7H-8s,eՆ6&olD w]h`IαW)ܳ)^-cka]zćZWOuK]gedk֌8OmpA=G 6XO+Kz]\!)N]Tb<2m4/I Եx%o?C k|kvf[j.ڹ9{Aa9jl\@AH93W6Us[uP:ǚ@*y-/K ejdz?,; ֤8FH\}#V9֬~ {B:,9<}uG6لiǽ{a h GS/ mr,Zom5 6mWv \kikigj֚TJz6`[ci:ЁlkWfl6M ȇL0t!eω%ȷf|H5U ܢB%C#fDf̚ȺÄ5$3GCkHsg"0re%h-,Y5f5;iq(sf3\ ΘBLs74+1`=2 "i`dzV٬,-afKCXۤ"6nt05C,VkQÆq8TJΑ%mvgkvA.Rffr~hu-q7! !&e挎 Dޒ [zwZ떑tEbhk̐uf\{ sڷ-G{C8X-+Nl`Qk]]$x 4kcBa;\fmN+V|!qehk ˛4.ƃ֎YYpQq̷Y΍2c myۆϊu;oE;Il 6Fɿ vM+Vd^$l`7vcTOsuF:!׵^T#^"Dls uҖ^@ܽ!a+ &B\\$ZYq3<ں @1{WSηtXѣ$ ,Uhp}X񀋔 'RWuh! $Hؔ:֥vqqbqlzpYe4׾s%ig[60[!#+vb ɸD5D"EydIZ斸2\`.UDĆd wZd]uiW6tdhg֌ '[nilHFA ;Xpap}l]E[06835+rq8B ̬9WjpǿfKE^MW4UzLF@.Zkt ۾\F>qĸgFӺƶ mia@[vkߍ&لu6ss9X>JB~7O`嵍#;|\xuDVR BbEiD VP3ZLh jIcf;p CKWkK}tVrug78$7-nh ]kd^-zWX=f_ 3}zg%j]}.k^@NX(s AK\YgG"26L"CVو3z 4wіff%C`L^Em;\p" Kcp AZ[+Mܑh_fފlT'5ŋxTbYҽ`cxL2JrNbePβ:ćLӳYcKVrSUVdXCXLpZ BvYp̖^["$j4Iy sGh M6og Wu X=s̀mbAv@NץZ>̲xc < ΌG26WƊ&6),ta u` YZpvVnk@ :5C&rc]g`iwBb6omH6kAqd. q(ҴK]= d}6gRNS9*^n T}hɘ(8̒G2uWc֞]γaCIjvɁ>s\Zt{.ɖt7Z$gII-(m~UfYp%aH*f{5tDE(BDD!B(BQ]%{!B""!B!B",)kKhĘB)Es"mqȰ$HYkNB&̴@SUI -sXs89mܪY0E'8dt]enpZo4AxԞ2Umai"@$$HV:#1[u *Ƥ6ˈ']$*-$44tfxxƑ@p)9Dzs;l-Im.tF'

J_m~` pny+ͣ3 _m[b`6a.\+Nמs.Sl-F4m%| /PXR(*̑ K3 Qp[g֬wPXa0Es ƇM dZ Mmm%gapw+y36ԑiZe㫣g뾝c-с3E 3K,@#?P 5D v(߂yENG'`kK,hz$WLQLq<Ih%i(E=5ZNf{CkOdX[6^Zm$,s ?E: ='|Vy EDeD/.TrTA/e/Sv9 nE/Sk%G2hbhOnҦRv:LGP\1A2VtHs9gfth 4a9vn4ŵC {0A6.1gfr$JZakGYYZ j2gfnì s:+:Ezm RF8*& #Gd)Tq.:tԖ͑menK1d若dtGAPo;-pÈ=": ׃FN=8iϐA&) pg$:44Fiզda;1^Ie 0:]{d8TeYZEYM[p\2x̯im6f"ȰzٮfEACAm/69TRap.բ,g0}!l' 1YxY# Z6(BM]-,znِr #E`#Z:/Vꘒ$nOA^۬mͯ[+ {1h\8U*edT a٭qh=Rj룘y5:M.-m1uk$oMs[La'0ɶ*RX 9&2J}$"qnb]#2Z2NՀ!@b/ *`k.6q `ZaQWA "Z8A5qH<9kH& M.ŬXm\^_h:yna֘Y9щ1R r0 S"4Cc@h7哚mRP]GEJJFa&hTPt:+5kwq~V vjwMǵ450`٠XNt82 Tƈ DDxXHUB۬m$-5Ӭέ]c}4rqqg1WBtaX{2 op> swEMĬ/HF©D!r-İ|.,[4O /BFc;T \k !aA=YUj . cKK2lӵ! 탴tfnOJRcU,D`6xɧh,"S0  <熤]^FA͵UTdB ۶oΫ! tWy`5\4r/.۴9e%Uamx'gU7  dk(B;{֚]v+W{2 V=%!yw.Uu^/Z@&^dvMZ0t.잉Uд!aǒL;F|gq 3jbj/Jn&r](%eg}։y.{Z:seƥntj#R_̊3W1y)׽CJX `Y6Is*.sf=%A8APiY;Y0U64I={Sdͯ7ޣT &YزCII;ɔE(1\rHi( 0+Fnf,I總$'!P!B""B"" T Q]%{!B""B""!R\@)6 \`4mqr`XI&2m<S-1NŤ`cg6dNjO)LDDB!B""!PB)B"" T""!F)B$[qI! t$fB_7FP4! \Gr)YYBۑs) !jB;<%,#x!1]u LK뽥ғY|6O:C8СMXXBT+8't>F-l5}9R,CEE9yM[-m C !M,l8ˏwy2 -4)PB")n"64F PR_ٱ&ȶ s"qQYkK&r +Ds@(p zHIkA/pkFdYnme;X˛z+,gvg@ܳUm|LRZyPE1.a)vg]yK>1V} RDD!B(RDD!B PDD! @Q]%{(R!P)B8 plș N9leulo8c kccLrJ A-I$I&PSikG4;0 m<>stream AdobedC     '$''''$25552;;;;;;;;;;;  !1AQ"q2aBRb #$%&'()*3456789:CDEFGHIJSTUVWXYZcdefghijrstuvwxyz?UWU'{V?L4+^WyZCFnNg| nN 3 1l[:oF֙! dg3qvp@ e9gꜪ&{H%L`+< 5( ܲ0 Q̫lʓ]ՑFMH£XP]w Z]8mYp!Pyddcc+Žܶ$m۝t3W#J힎ZpI$v&FRa~Yki:5w [$xgzWorMմZNm"m^곶dg"EGoBN`ׇ@IH!R;f CܷAqVmI{Ne$i8UqqXAsbʥЈne͵ ڭQQ\c+bⰷ#P3(' &ˊ ԩ#  ot͊Yc&b6ץG'Hp#q{&FxI̋(7k*AkE_z^l ! [Ofj{I, Z*W8~{Dn\emHh"׺8A7jGm6׫mz:pmDf Gls^Ɲ2iHhl&ִwŁ[B׮Mrgp[גxH:ƒը w 7SkQg$嘷oR;YS,^ ^OcWW}Mgi` 1g|R)qߥ/2:"',66`-dP}y^Wy^U#<-/I~ݿǸd2~դ,!($\3UW4-wMaWy^Vpږ憠Z/=#-T8 6P1RYKv-¤ $dAcl(x#q[H̆́"'=Up&`  "7 9pd6T@׋̻ B]V*`Ŗ`QQ^Uv l:ʳZjmկWgah3a7ڎTŕhɈ1|I^-FHdμfMрpB t R0*MlۑRX (! ,fLgYnc1P:uoKe,m ( `g^F6FNbFgZ<N AזMnQK qD0NܷT|nGIp+#9eѭm—wd QiR- A p:Rm+Jsk(pq$v߾XV`@ĊQYG‹jII biNG#&df& ;>_$ז.§ 0,D*+ϵr{0[3Z*bVa#8ʪu,`3wLf EwsFKpF3=C p&3Gt9u{vn3RcjUn"Hѩ]*dP5fY hk`׷me7WvJvR50=oøGAfޙx ȉX<憕 iw sc$I˯++UWoC|6 T+򼫜(эt]"GaEEKX 2 YTJm.0b25{@! pJubN1;+ܲ3M]U dr23ʭmS ^QZn2UXI2ѭ]\iŘ9w֍6YT, ]g67AwEQpĮr$]¨e2n* 3Q9SE]*^cwoIԀ):&6fsB g0eHMk:Y;C4;z=Aݸ`0qvYr n<:TÌ]!c qW(_ÀgY"Lts[RqP;"\n 0Ub9 tGwK^P0 G *Ѱͣ-uz5hqE8̄hU Z5l.Y#Ld35o{B eCgF)/tA.Mlw3`Ka6o0ċX;gbwn]$[_ըW+qbds\kWm\23z5cI~-[NMTLKmG={gR+c!uK:W3E8,dNt/˖n_Fo\')γ+kl-eՉ7~)tUW%¬7uy^W>'K7-wÇ&:::cuaADIŶ11&Y˶=K[ZAs>ΖGX)2eci{W`V9 l9Ӛrɂ"XbjqsS9S`kOoKm9 Rr˦b&{!x25rU*-N-"{ woxvɌ룦QXjF+aMw;[}L'KEp%s My@UWy^WySh^BM)\\-^ηt.j)1qT9 ZA2LBu%EGy@;5^u&d iA*+.6T HxXkT/hJ)9oʀUWy^WyVyxAq \A'kC0dsە\6-5ې2 ^CHU; u;a{{BNvkl,Pfznp$U%&',|VdU[.9fAXGa^ .ȓs媗ҷaĨDtLU|J @&IA΅maTVG?F;'NБ-ڦ 6`k D\n^w.@t{ZNe4hpbl}'NoIDHi͸+N$`ٮ6=,< qWCVL 0.Hf:l,C6 uT80Z]<l.<\ I|` ٲ;ɭJXXtJYx޸+[^0mgV+Dݸn#N[At-W `dfcUQ#IE΃dT }*9*23$וMnPUZtsR29wBD$(R#Yw[$mt$W+pMҸPz⧵eTp%^[VDf ƴ_W(%("3' ŵ`PGK]d?H[h03&{\~f:<5*Dݕ^$5 rRZFK0U_k -qA-:W՛mɹ\v+>固NXTm'+1y+,uAqݰ2^ғH{* !bz"bސst/AZfժtuC :3*(mIsP3 p̰ uB_sm++UWy^WyV4,\++Y=:(}>+b`sz{k e@` 3\0,+ g|WJ[aA# 5*hpcTdJt)W2D0jHe1szR5WBY@'-dԷko2.LZ8]I8漄4[wE3> W] Jp=VF[Nq'5aÂ@2Bԝʹ(≎VKqq'i7aUPoE2 1ES^i]u 9e.C$e)@BR5fjѭڸm"Hbcj . 6*xӫX FLvhBwVuq2ı5gKdyA@ H3k]dR lss#K%H:"qi&ւmY jzexhXqA k\k1 NdD׽5udj̉kg6b[h^%n8$#`:9Im-y@ 2Պ[ϥ[ 2&o_UU]FNw9]EozF.#10J ..G$"&HlkאR2}y^Wy^TE&b l3tUWy^WyR4sGkXwڲ.+1A3˶YǙ F&pfJ k{:8xhVH2a%{憀kX ^hcNPcy~GgRUJZ\rDU9֞.\=L(vDvopfnZbyxdFUin׎"وv3>B!@_IiIdHđF!YC%p=1PhԹa:"ca*֟Z4{jA$VpyERz{59`lWSݶXѿlkJcKeU)l69"GPgC1T, :HmeSJSmٳf9eW8DF"A'PEIsH/[>h[(HȨšc:aAZz[m Hgj墚3\@(F'WB]Yj21Q3 T|Ng=p͉Ѷd'ߴUn jR0LyLUҬ,\@MmwLR\1Ép Uօutf;θבLuQU9Б5>ki:96\`܋.bH=X[)Wy^Wy^PUWy^WyR_2j#~}H2#etfE`I mZ6m s88Fj^ 60fi5=6ջeij>G X]UZv-q=߶hC7|C'^ӘRи] Ɂmhx6̓5 樶B`'nU]9}IUUFU|0@鑞Vms]N CCD!AKIm-v~3DbY7n &{Ӏjȃֻt]nApLz[w9)9fzb*k!C29n GcQڶ -2"u綻dրe!BbkۏoIXAm zS_MsJn nb]d楺5sF%nq0 ; ԷA w I:Kҋ:XU(e*^c_ٯ.l H$ 6ĚAr$y@\xk0.v@P՛I-L "2SWt0Ӷ m9 B|<-#ZUyu ff-ْ9V59tc}N= tc Mao9ЧqMݲk+(UWy^WyShbtbb[Yea0g] qt9e2:Km$']M0 1=xcfD7S@i[EoK*pmTUWy^WyRh/!VX]J \GTW.`D=bU|b'ke-xy@",L9 ;!E'% mWrþY 4Lm 8Gb+֐$ W8B$AcP% A&̬ mL)Sw{5}J- nLݪp!ax鄁FZjWB\Y |%tDp93]b&arБU +냿mYt˞Bu6UYg4k+a_"-o|tD6m䙃 oBt-!fV\מyvgMRp ,gVel\g ˓זJvU{v` Nygڸy F *yT+m,  gVcYfD>CZ6,;Fgb@P3uu(ÐhH T2)WNͼ I.Mq5ߺ.pNU摤s"v+WQu*FN 9#w'1llm>#R+\0 tͥ{'iShg-[,ٮ{*‹CmϊLMtalvf"ls sTlee jbA3#^2hN` ڥhMxlf+vˮ)& Ö Tjy^Wy^U#N[KWVʭFՋh&M9Q"@(pUWy^Wy][k:-œD yQDdk1 '>{XqAșj|-lpz2ll[&\2smҐpv4dcXU]$+b'i״U^f ;9Y1Dٚ9hkLԶ,b.)-j 9FGEy7{VU*ht՚ë]tv*r@f+MneKbdiV'#TO1Do׈̌׷w#TxaTՋ9^[p{3V-M,, z*-*^vv/ =gFJ0G=:uz$ +իj~PA̘<D莥{a(@{.xˈN]_ %WJh;&uX8 mzdnqr:xl+f{,`eVkI4LlD! b+(UWy^Wy]$]R5i w]f܀uκLJ1ѰR }vu5x&&fDG%N.]2VA¼®8y'1\Vo\B2wIW 2Ƹ$ԫȐ >S[D!A٘בa;#157Xp8J@W(`dUo6-\WJgHef(IOHؒ$f rVFZXѫWpE1wvU!q %@^+\,֢zUɋm1=ZY$Za5g]"OeSYdjT$j$3^́V7ʈ -),9٘1˷S"NqيJl]Ljkj7q%dXa΢7Bg&sQ˾WJݮkM$Lf"bD\`B)+֚a5:jy^Wy^WUWy^Wy]ykG,,h:"T+W&u쳇[AaDM{$ Iuץf k\й@ -:D9D^#/S]p8,7EF jNk*%nԳ<멞Ѷ0(2cVZ%Be[Dنc3Q2mN` <)D- sFGQ$琀bҒN3et%FB3 ! */ x\2^IDHÈ X %@kٺn²a1¸LldO-Ofēl$U{ deMx,`Pd $5Z3c\Bܵ*@5 $aĤ^Wy^Wy@[CH`ZK)KhgYH3Jt ! x48Dt'I'%XA9k4rE #ZFȐ d.On^ #2 $^+)2W ehW$1P*avғR6@zw@bdٗiQ*' 9Ws: .g9+ c15  lBZp)竳#W-'h%O:ޓnw5 DץFrGR@Ndb9Jt*\OkS5X'VȞһKuK y&\KʅՆQ"54{jŇ$׬b$JH`ڕ2'U`a``rnPP N+F`Wǃ (9m/8$qvU[g[8Nܓ5Y-!DB@icuR++ʱ'3vYQ·@U@D֠I Z t[i%7.^ȶn>="mr#=Sו{\.FŢCuapj Z5y^Wv<}]嵉I#\oSs'WB@Ք^XfpΡ[S&R3 W8kU AYx-j`a#nޕpQ "c("`dg#59LΡ^0u@ [!=%:Gc\au|O-zTR@tuH F׮9kQpbU׸v]l0bFKS^Ŵ Ż;r+҆'l2{ܫ>stream AdobedC     '$''''$25552;;;;;;;;;;:  =I!1A"Qa2q#B $%&'()*3456789:CDEFGHIJRSTUVWXYZbcdefghijrstuvwxyz񃄅?UTw̡zN/n5*TE:o:ɂW(L w݅$}X  fĵd|Hz/sZlj7V6'[qS>%Wj앭LS67NCɅʭm~mxuNc9H k:6~Ml>'S^(H$mh8\+Z쥀MŚex:s*x1E/ZbSbuvN3\s쭉y#ٻs}l&Tav6`Ro7[6!?z+Q Xs_O&Kg.V*TR?9eY!&PD.#P˒|<%g2bM)ENVUTQ8+7BRJx<|+0 86:UI6"q.϶՘p8T!HZ @ر#G%qrOv՟6$g!l*dla) ;zZ8M%F"Udrm5|}%*pHҵ'U. 苪y8,&ukZ8vFrf*sA{Մ5 Ɋ.bݚ@⤍b_z3;ď.3$c2ʩIerK<$'\$cA{f` 辻4b.4,lS&k\\_M {q@vn;<`HV-yuT$)ƹ N͎{&=Rk՗)A{kͰ׏N*X4\,W7 b -_]k^G8N ii,;b%.RX$랥J*TؑqcmUTgSq}N{dETTR'p\/"dѢ:V)rN퇷EpŕE؋qU_2>KRJ*T@UT .NƯERJ+.Gg8-YƖPQ .oӺLܫPm\ p5e ` C[VhE 7ױ'i[fbKA\dmbsZq0M)W*AN<]*ǔIjI$HGy4nLI(#Toe&&\bTWc[)&Ax^*D|륈%浯nz'ᅉdC)RNtIM, ikw\2"Q{Y3 :و䥺E.3T傀t ?k]8s$؆<ڹ5ԙJ,j.NXmN5*Ymv\RG7ݍ,Níonb,Mċ~r7\*P}"⹱M`Llj x#c%lr["<r8$tVc&b#DSra( J؛  x7L!>aGMɭL& H#1ko|-pL̒eRGdMOLщ_:^sQL 7,` ;?ƴ^[b$v@}5C!A Nn kF3x 7  -ENO,rhU&SyfԩRJ݃IĦEy Ɨ՜i#)*wi@UT\.L ϛRJ[$6IݛΖ+NH`2m8"l=h6iC#77V,lڀ7[q08P t&6my.5q 0 #BuN)7"(,ܕ;!%NI`6ٴmf:{:K}kEJ*TRUTN#V*T]JcKZ:hFV#2ekk]Ie1Hk7dQZLp'3tZah2dpZ2hyQ4j,͵rØjш42&'AҰ{iX50k*zi#S!WO%$l_/my#)싲^{^ʮ\V.ervҘ`zݮMͨ=k#˜p6`0A^xIeslܝ4ylj^;wQ&ݭk#Â/s|l-޷+eh$VSr9sf*O$.L-7o1+2fbW[Sa]}f.B5ŵkZMZ!l޳lkUb!N,(+n] QD kV {kPK _B6WF1^Hݷ[ 2G=ɶnw鲺$Vb$ [*lUӓYxцB bA{]Mr*i C@7H,׭\>\A1+F ;5щf7yC ܋l5ňY'U f|!3jɰbN(~*I` Õp@?ֱִE{}{gZ]r7k5/xO(,PSulNf6j*TRJUTRJ(blE +4Xq~z\qpH7[&.Έ#\. BNb u'k.'Gb@qַAe+#\$-^tGP$ۥD*BI r"0&v smMta(!ѡkWm \`82)nBT_-R|>r8J5e++xΧA!A m}+agɑAˮi:^Sxԝ۫ @db#Sqcۥzxn8a qp+ qGn;8pHZ pm,LzБ`+tFWI f݄[¢Ĉ\\E1؉,I崙ZB,)vk+&@4ݮݕ %v1ېCp,9$jlLr}@ U 4I+ؿ=`;·@If Bn;-_Ji@23hH2y[kCt-:Zw-Z1 C)̮."ZB\;KkEJ*To Q`,Pt:_[8+>*9hУI'n@UTRJ+3aef),H{l:_~aGXãeuC,rDInv-[6f:_& `SٶcaW CkN*EUՄqbOeJJTm]8w5--yp&S*͔Hmu`[H_6i p(n78n&,H:5ڮtʠ.a`@R.Iwև,Dg3,FRJxKrE-5?6e;<,.UUMNM34K(6w C%v渽2Y \E[%+m"p+bZ{H 3ހ#8ٷj?ki!Rrm~E!YYPT{^<%1Y=q-sRJ+8Zd,TJ* UTRJ+ M## tQ%v-!Uqm,Fbf]č幆\F"K }+] oj ou$ڋ\JN0`C[d8"6brXqbrH,DʃokQ4sB H;|x01(Za4K t̹hN鰎xX: 1!<1n7_ں 3ie Kr#}lw2#BɖU$6۴9H&ǷEKu0 Zm[`ت%b eW0.Mv5Yx@؁nr>:I3l{9EpCYuo.Nub !BHmޭIȒu mpHzэ+"U̾ 8֑ضsi]0b-- [hXa㴲r8BZARA ؊UTRJ+ʲ*FqJ*Qrm;{BaD/6sb11^8ؐ21Qz_0Y\%p^L}g,Ȥhk[BM 7 q6pQv_2+DUIb5g6= m=T a!B.݅VՋQh/#O$v@ⓩyJl1.cXM @m!A\Cq=ĝt98*"A*m̠ ֆFfap ܟ Z[E0$E;V<<#x[B' /]V.; f]  bd^iAQs:.Ea~ffi8ɹ2ݣaԺ 0Ikt WWXd6 3{kk^\`bK cдqI-c+OVV䌠mwN\ 6@w:VMbZ8!l߂aטciZ4 c۹QLOp|c+ˉ[ XXᓪN20OlEسvk082WGs~Ƥ Ā m ֈySKa`B3)1XZxE,.-@;ih 5]n3;3m$5J*V6+OvּXtr[fQϥn0N] <0\厥n7{TˇCQ{v<6Mo{iz..Mt [ITssQr4,rv$ؖʊNtQI^,b&(5  Ôi 7xo!UC_ $ryL#&?V3NUBH:QN Kr3>r2I ģjUj^JIDH6_mr'㦗0wmz9CXhhׇ:W1.I-  b4xWP½q 3߿1('\|rֲ\6 q.d@]ּL6d/8.AY:H8 31MuwXka[龣^60v-n:, pOxssfgF)&Hf@-Eaυۨ޳HoԍA%s"LQcܠ8uĹtc[k]J*TRUTRJ+$b k^D\l9W>eif.scڲY\f [}+%j4mtW++].V#V% e 7>ta`Dv&YRH%XذHxb 2ɷM㦊S #9L%Xe[>S("CmT\s F|ق&lwԚh>[C8xa) PIőF^QO5d n"FEix@q9hX׹cj>0X2Wzw7;vk *TY$RIq3nPO]|O³42#-)bI:׃] V'Mb:EP.Uw<49%oq`5;}rIK.+j帑MlV d.H6&a0yk0Ȅ4-e&oz#Y$5C8~`y$IѦ,\XF ʹ%\؃n"2sfZVL<@6$tlg`\(X km\LU)#!7_XԩRJp pc3n.|Hs,/[8?[&xq ^n7@o!H&7ƛ/~*UTRJ*T^Iܚ)Ln lWI+{ 6+aD .AlQ#pMJW ]to^qq)nR۵zp3gkb*}AZ١DblM6,"-2 Ojw75UpXv^,qJą@z+K@bbM5-289= N]0>d,T~kmۥvE؅uwCb\ *Kv a^G,i e;G>D;(V9 BTb>tVS!#,mZ1 p:B[٨bYS(u7^S 0#He;+~).!,n,=$5XH#A77*@uϭ`GƸh0Co xIp8QZl,o"7(N5UpJgI2V)F=qq,00eW4 7nJ^$Rr0> L~*h屰ygJ:bu5J*TRUTRJ*VH!ʋs^e6`Ab4p;9^+>Pg$t@s YߣM\ Yk}a0dI- \۽r"lts[!0gEfq,M\į+g (aݘ޵츼\#~-FX6ht5ȲLAF̧(V@1F`v ڠĜT-`Dl7>|' ƼZE:K-)M43`vRJ LV2JUqըıMJUTRJ*TSC`("⽉ 2 NvLcF%qcMrwmr@ 6ФN6AqwcXZ0RQz> {ĕb֭6`%:☪ŭsϦN£+1]V-Ht I"9x:#3_{7bycmkqJp)Hz8"@ VTk! fjM0%BE/bFJP}M` )X\$ۚmYAٙu;GI$*n^.kD+\$R\H65"Wv5]¨0eX^\Džx dӺ{ pFDkYTt$Ψ0-Ͷ[m cnV \tZO%3yg+ A2M̒3rMkRJ*TUTRJ+RmFFCfׄP^Tw0vNl'[]#$("z'qec`;h.Uŕy!ڮx3 v١Qqszc]p7d}N1CMt .$L"~-2etu C#ht۶UTRJ*VK#ExM}{.{!w17 nVU+u@.Qՙk e^K6pl#$i+‹3TԞmDp[<0mK4 5фuSq~Ϝ*ګT_nX#: K5P4lu@ ^׭85e)ֵ)WxmCX/oJ'l6\efH ;DY06j e|} +dXe3Hu w kk5 {6f蹷4# arnv oe$2GrT٭`p7ڡR-/S|þ4L M?fi h|-R\T@X[7J-G #Uk5lϿs}/Zn̛ېz+l`WΌXڼ02mEkmku*TRJ*PUTRJ*T[:|ğ* d;lx+f i"-CVk)W"2@%:BsqH+َkݰmNRGhΡ7:"]cW\HU#as\g)|甠[+÷reQ7ߺpM {c0بaR$KRwlK@2|Ӌ\c{e|[*EZMHC`T_B+`X,yJ_iadTTwmjxAI$2˗g^u6b\/c}| 2eW\Ĝ\Sa[27M]i0Xy]7$Xʀ5 ^$ٌ7kaV#ϸWjq]elR%̎{p>ư&wRJ*TRUTRJ*V\[e-qaz rN:aJ'_uĸ-Ts aடLLnu*jG"xTg _(pf+EJ*k=5 ίu"myb#FslLU(X&tnjÇيZ;a/[$xeU\\p|+e:[hՔsa $(/f7|s;kx^9S9c[-WD]PcaF\)z# OI|l2&hXDxBd'Rs*Ѣpx Inn2<Hm{VkFƯs$EٙkhH|[JܞL+gfV,ZYgH\涝]Qʶ!\$N1XXhXGsam ICJ lߥNH3m2iMx&Ki"=`4׏>stream Adobed     '$''''$25552;;;;;;;;;;   ####''',,,   ####''',,,   ####''',,,""  !1AQ"a2#BDq $%&'()*3456789:CEFGHIJRSTUVWXYZbcdefghijrstuvwxyz u!1"AaQq2B%Rb#CSTUcr $&'()*3456789:DEFGHIJVWXYZdefghijstuvwxyz?BWH^W<Ԇ E#Az 9N2`>yDû}moV0!íqܝ}Rbս6n~lj.׶BhBP$!B)BC|cUI$IzT,3 &u6njL! qNw7 .8zq^<61l6 OP{G=8Ms\,统GK =Y[K v*Bn?o!i JE OLpwc#Ӥ1gK%U!N:[WىnW@b'ӟoFNjZX>bKNpL5@x.p0P .!ߐ;eqo#wxnQblV@[zVbK}ڨaazF$8@QnxS+!y :F1 tۖ:t>rB,; x' &Dv[P^Ӧxw4{E3ù1h^ڣh;IA5KjZ\0$Bt/83ǹ9=Jg4{Ey/LQ_qZQ¨ByǩP7(*P--Qʯc^2*pT`4Z]ւHWfPH1pk\kA$! ϧLk|x(>1BݡQfNuF4fRWs,HЪqŮ4A0A /8)[GTNcPj^E18 _OfJ Ԧ~GU?0ӧ RoɢB5@3I{ʭ1!NayykO7/Nb7sYZ.5f5 CVNtB3JM`v17 _gPrnbGtYV4U4\A-hD 6<'a2qG0 `T`= 8oF$!j ߱lsN(;C0\ѥwĹM>O-/jBi+/@BDfnvjÏ0\,t¿uRduأBѹ{}kkw֏dn3l@x~彟U8\B)]J!BPYY*OYNE喭-HjF {4 (Bt=o3vX 3 J v`QҌw0;W$V0mַAURuJQfeg AV JWJ 2LU7`3@DHm[F$73'H^.#XieuڔxkmJ7oV}Z۫qn;so|2lb|]yܠ$X} M.n>+s}XSFI"o\MQ 3jЧDpHPWQv˳CZ^㹔>0iqOiiaۻ܆b&}5 ĺ냁tR9Ϧ]`\`U=&EiU = i͸ D(R#8-Tm"I8T$_E X.R O ]ZAݎѵü5g.kk njn2{EC( iic;4!S#mRce] hԜ#Y@ tdhsULhP!+!hc]Eyɇq,waKvg-oZ.WL0LpEE%ŢoSa5 *}Wɳr{H!f au9-k%w3ӊs*ng(َ[\";:Cr^R\V.*j ïB!te3Q-<&Me~<Ve2P$0D޳WZ[q9!@֬]ng* t$4F<Z6v018u8'1=J3 ٺAZ[ܾa5NC26dBs,SP1Pqm~;V斒Ra1$#*6˜\ Wf!~V8x9I>E OT[F&<0Al7H}k@פӡ|  BBf 1G 23!@orǀ·,yy-.L\6.zSwۧoNw3;Cq{ZI=H+Ȑu!a H3sJH^U_E.]gkC P+d憙 +w/ Ѥu6p݃yh&UN`w52fP[!'`Llh;V+A; "_"vw'c? c\ÌpW7RU'^G<7䜁vmn7`q%c`]"4 w3/kN⮰V6m=$m}Vp+güƴ Xhs櫋C̅gwJaMC,l5(^v%M %D!Pl@spiCY&:bvf,hp$0Q"@GwwN{K{t ,$#MfŊN7CQ46һ#*6*~iMI2-J|˅T|gvZPob9;V(5 Γ}ڝi0=5tGv=.݁35Q;l񬎪tI5j|$g +fn*-%HGpSX^۶p@xpo9ބ+lvӔm-ce} 8s}kn;׆`yZᎱ@bWSE#}FNLqI ewN~3wa{ ɴOhHNCAe ˱at[ݍt[~эrxqti`R2au;{T|gZm hov=c9ib{`{GtkM8;j{V!Mײ<h伖h >p֍a^Qꫨ ~ kismM yˏ/8sD%LB^lǁc2vWJ.x ]jC1F3h,=Av,;-Gmev`L7K5A5ч;Q U:[- erRrܹԪ.ݥB;vg,N jBBBERB PqY\IV1%J8yˍ6G0ʹWkX)G@!ZT!JЄ!B]k:sDrX^{fخ2H\d긳/~!n#RW[5 ;.Ӧ? \ H;RԶHbmEf+%W͋ ݖ h Ǖs{[GWQ /+C]8p]N9 bIBAI@,\LBA53%{V8Kֿ ] IΖӸS 6.ŻnppxRw?6L}yk.+^].WuON1puͫ Nָ!mD s3Jh+0auִ e]u+,5hH#.  Lȍ/du{U-ZJHi v%Y3fR@, n`!(qƬ摬k~NM a#"Xn#ΥEc"UPe `vc$! N#GJsIhç'ipC@>8)㐍'=`Ϸ> vBxh dsS[\L@|ơHx+EPtAΡ9"@75ufC BZ ʄ-[VݱÛ\ֻ&DWgvrqLWp{6&3<6c8yXsJLinRaWvEԪ8 :J b7b58l'yʖaF'x= x1ufLBSq9X3 M]~ tM'6, b9cل48H^뵪laff.KQG^64;INd@a ^~PoN|7TO$$/R->5IƋ۲-bVuMR_{{E̝LO+toÂ$P$ďFRӛǀ[ ӄi+St:-iQTj9 {ΔޥOQa^ӦA_Oh&;iƛrv{[NN1`,n8$N.1`:82[RѰ;fa8خW{iv_%T8=G0W=]Dߔ$FR{m64ގA^| ?$ixh8xsKb|-XvF2Nfo7gf912Bձ6Q|<諪,Mx3^!Ϝ)ZR͊Np(1e_?K`Tmv+pNN\ `dGl?&V.KdNˌ捥;vs.a2eRk&Zise<Á\0}@˩n{̇kٰѳcvd PzӴ%xvlF89"bp#8.310]ӰZ f.}U=XkJ-$5N pFa(aM71FpEN.NYh`蝊չj3m4;$QBK|-&}ٱ;ۮ0kbEx80 DK;;VZfc2 C FoW;{ qʸRfB!p;Cp1=fAp  6#0ROvc gKF%3g=&66[Ӌ+]XfVQM'J{"h.Ј\^s_>ɂ+7tf ֓0^j[SzխkfVM:ƻ}_ftBv;;(s`Wl852es^Ŏ`N(->%aAY}}QֻhzFnVZ2k[ba;,VU}I5$#Nэжrvh;J仑ܦO#`pƚV=ɝZ(bKF։/}7Į^atv~';1r`QX< hxzJ֐C[C Ii8W4MXah"#t*HYc\D8 㹯ZK67#We$F`\4\`ѹ-+[7&+I9$^)mk״sr/ԡmQfƋhט%h>~1 =~ I:6\@Fx& lkY ڱŧ=tsP7 W0i3DjA3`4|q~1 =~ =~FS)~%ɥ=G w QOˋמ]zIDTM::-44 5#j-6syGG%=+nTv'cضm9؎6bb߮8yZS,%taX$ZN%C@ԬaCh>osd2axft^j8" 8Iȸ\ 0,x<7Wy%][vU o!:tȤ-瑢*2ZH)I\sl"9 aضS3 uZ˳mX./i3ORݫi.郰݆s{53sٶ^،n#Mi$u"Xp'SuÏVN&Ä`ԖMF8) :u9`hQX 4s|MЉF^]CiVױt"Wp1Qlakq i ܶ3o۱^kĞv$h 9 I +jœNTD>B 6Ӌ:M3_j161)]~/r_͓K$4 qˀ]sI%m&2oȫ8g(BԅSh۾18(8;XcHhnr p֥rxd6wōBJ!B*BJ&! T!B* (RJֻA4! ׵lqGX7[U]@kXֺ^d+;0DV`nd!p^״mxXp{綇U,Jgۙ2In0"|m]~H\>Ɍҽ8wȬmvCZ.9ˠ~cv!]KASY\N?>;Mj|*&6}zM aJw?ddl's|QAasqp&́Iv![FtT\ަ)A TWªu0``v>wq;6׆N8&*!7BdLjaorPhs! tػH4C@*vݷm͇'L 8]ѹq3f;%n%tRQϑM%_RYktj+`ӫ2|/ *NJZ݁>V),=iuhs׉c8k{C}H l?xy-kgp{1؝Ǿ3tv֤i C+mel$,}@9T"^f׶bs{@Ww_a^p\֌c#P/cHit+j1mZKۃZApRlh@$2_vP^pRdI'e,kYفn|cXL<F|ڍd nZRu:]((DFK\DPcrMm8x8kx8m{N\fcE k't);3d]*ݤ'V.Qu1HC^% ٺ2`ָόG::3I{'=C;npv.˴`,H5( n°p!bE'L) )!-;DlxCi8W9<\L;oOe.dl0ϳmp;cVw#k\ۃ* dY(ڵU w"*е.izB]3Ã:.-7A=kff1 %[kOu,\2&C`JYy \rcM12(&\K7ٰalM#5L.A,L;w?>\75Yȓ٨Zm'腨̣QnBRN 2Pjqv7";ʵl[&ɆN'HVf4vp|p:%wىwÏ-X]va+_tc̾dʢ U)⠡Jx]f3:7[fW,13 2z؄!B*!BBЄ)BB(RJB T!B*B)P$!B)B!B(B(B&!CB3ܭaj-fT"xB !m/pZaq^7t0z. qAx8bz$L䝑B;cqMtfW/ ,`hUO5=fv NfЮcpi񒑸%1(C6b[kO%.ٗG%r5A7]ՅY"|jvo{ԋBm+1d*v.fɳr}"}7I"}=8G]" uѰ*/fáy\ qRݍJSwv{#|ܾEeyv\-5sXn-. 6?tfKCA=ŃtFg'BaM04; hT!gxF5k^ | L"wc=x7IY=/{}f&; 7_(T7 xHBM :+gtLB'4#rgi16Di{}dvӵ}Ã-BN0c:JL:0Nqe m-baFP4\llldi1طbC๹G|R0w7e9ٮ'I9$liv!pq3ֶ_:.擊H\ϣlDمּV1VvsQ ͶGgj<9[eqL' xbg@vwcg.^+qD\![f0ZgD;KW<^2S,Y-6t)\#\ c I}7 |e˳?eʹB.⍫1pAH裗5[AYXPȍ%Z.7lD uIq{<4Vs\I4!BI4)P*LmI+RZ:J*Zf!9 EЅmچųL.;J;c7d3#b0-sZ =@AHc*HMTN>1\Æ^$ڎE1JBJ(B(B!BBIBBi!BBBJL I PSWBLHCH! n#s/XLfTmX8pvȬ,L:A"E ,I fn7iaMPi8gr ~g!_dba"P۶ggxja&ZhZ,iXq.g"ñpGpq4/=~wa ګ֖Z) `9݆Qi4.@ΥJm$isA#+/t1^l*>*SH׊8sO ZӑR*ߑPNtŌe^|}#qlly}%{ܥ~0 y7Dž\Xܾ-RvkC[uاPkpxh-iBs06\2M]9Fp\0ppV~Ë13 %jws\9Q.J1 ҵ7A8Gg?,oSFEQqR|57\i8-p Cd5#j4Xڋzֲ;g'g;9^N?EJ/L;z' P6r& L&b`BٳP%S=@/ NKzB8I8>;9 u0v^dEZm (Z# FS#.;{n+0l\=o.It67;O>T Ʀc&hYݲ!Dz.4kvg9Z`4vƊvnLqc%@WAXUKhLVk5 ߌ Sx[N.ϵa2H r\״㳤`xW!X#Nuڶ &1F":Hnɾ$7i! 6ɝٝOSmL˅8yj:C%aQGth'Tiրi'-,{?s17ispy){!+fV3^iLڝ<V XnJȜ/7 'r6kN#Elm;NxKs v 'y%5cd8^+874" c`1oxx=^RiC.{?vf`^ԗܸ`Lj!B&BBM%&0ALB .ݶ`v;ى8M )Ӧ KoPp R-H\Wt .kvKL7es I!I /@B$B! P&!BHB(RBBB(B!B!4$Z (BԨ[QʘBCj$Zf\Q3Ee)D!$!_,*[ tX+HLzFE(S'Hx8l``I6),T-+DPMhxcLۥn8xsx vǙ}Ɗ2nଵk^8IFPP,.n`FEdfJ/ !]p%]s2`fZ)@`Jā"(YN&1ɍ vi3<~F\8|ӊ\2n)="K栄 RAi$bK?A ֐ND_rvP׈i++Lx (vMkMI̸(RB,FŏÓ4iYvm(Y/tammy!){I7M 6 p &h-k ^f-I XE( P!PB!B!J! Mcl)Bvc8N+0pƯpk|E5:tJ6IrB&\wt|ӄ"5 l6bLFB T&)B!MRJ! P&i! BЅ(P! T)PMBBAU؀!YJ&!RIBoUbBI 2z$Ј!W<0KB $J *&fn+ XpspU|4AKv!펤mShPa0 *FBN>+ѐLL`yNYˋ@[0`c_f$d)d^`P?./t*jgE3;z[a(BAHn*.qL!a~1cwX-"a`=cx*-)D a&L Pqf%7@m`pĈ*0V@@H 4rH(Bs 9CIschhs-R&Qu;JI In,F,\،6B>FCf L dA9l8`ZhqdW 9吥n4|! Uj! P!B!B!Bhk-%8$!B6ÇVY +MZޢI&JHB=6ۀݛ, aWoKVƱB P!B)B!BB PHBJB T! !J! )PB! P!B P&J! J:!$B㨄9ѭi:BW*xʂOPbƅ EoPērQ}(3 uxXA \"֏vsٟ. qE^`lCCY!e)IBS?FU'v2t#r,Dh:u5 jy/̪JNTw?Ѵb1!slօʿC0Bph:|!qX>)n@ ArpLP0PJ!Q-HB%B@P(*.=6i&.TB!B!4$(BBi! T)PL !J@L=icfAB "1\m88B982a R00l63 CX4& Rk%:l֎:M8:Bl@b Y!i=s:L{ cDOĬ/s0qLbӟ5r8RUE0H$]G! 7's10݊07@sKk45ABC,V 8 4MXx=&.baۜ ?-/4Tr (p5BUW[R GjD^*PlgD7)"!  ^\$"y ܒAB-q" i)QȔRy Z aU$F֚֡)ID  '+DOƺՀ ]4!"=nhU\!(Pnƌ3KSBHB!B!RBB!V+(R!B*BJ!4!J!B*B(B)1 q !#l06 ;C0%ǙD1{{׀Ga b$̅K΃eRZvi9I1!s$k+7) QR{GCin PcqzG$U6>.1Wd0 :3{{SM gJ11 #:qlZ$ ȣ `6MA Z6\g`tCrZ\\th &.l64ffoGO"Q ȪLIʄ!_wjvpfk6Md&`a LIMB)IB P& T!B B(B4 F`ORBHBfT)Bi!P(MBP@S !Є 4ޙCZu:I`y &PPWku`d.2`#@9Ћ(sf iH ";0VSz%Dit T,3}!BE=hhS! 3gĂJ &!F)PZi''(B ʨt(xS" !!L R^aY7IMWP!$Є!!4! #F`8B#T!B*B!%:uI3 B,! 3^ ҥ]G Bشqܪq.qvs)!\?u='6Nl}{y.Sx'00OPV6 wU3h>.ݯh`0^2)cʉa\ꔀiQ $p;?s;ipq eqi \C #3GXGX BDDI B#yQ#yRBhBHTHT*#yQ#yRBBDDBIB:Ǖ:Ǖ 'z!:Ǖ:Ǖ$&!JHTHT$!:Ǖ:Ǖ!PD,248+HTHTJ%$ЅG0JCHڭ#yQ#yQ(&P!T6mCXbUu*$u*N"%#yQ#yP!AjCtS#yQ#yRBBDDI4$!Adu*$u*hB\dVHTHTHI4!f|d~P5N,lTHT!B#yQ#yP!JZE+HTHTŜP$|xͤ=07/ dDL8%H!ffF;/>+3v-~0 JGXGX2MB $qLQ#yQ#yRBi!B$u*$u*ԡDDI ! THTHT!$! PGXGX J BBx,jyq_,UY"hB;ʪB*QeU ;ʪ V*J &![;3(Ѕl(")V*D@M%(V*D@Bj+gwYFwuT%BeUP@Bl(@DЄ+gwYFwuT%BeUPBhB;ʪ V*J &![;3(R[;3P[;3 QeU @D&![;3(l("hB;ʪM U;ʪ Jl("V*D@M$)V*D@B[;34![;ʂu endstream endobj 1938 0 obj <>stream Cyan Magenta Yellow Black 06_07 endstream endobj 1937 0 obj <>stream endstream endobj 1936 0 obj <>stream endstream endobj 1935 0 obj <>stream endstream endobj 1934 0 obj <>stream Cyan Magenta Yellow Black 06_03 endstream endobj 1933 0 obj <>stream Cyan Magenta Yellow Black 06_02 endstream endobj 1923 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.315 Tw 10 0 0 10 70.8661 724.8299 Tm (\r\027\031\021\030\036\027\027\036\020\024 \f\r\017\013\036\r\024\020\024\ \024\021\r\036\030\f\021\017\016 \n\036\021\024\007\024\n \027\017\r\036\ )Tj 0 Tw (-)Tj 0.202 Tw 0 -1.218 TD [(\007\036\027\017\016 )0.5(\f\035\017\017\f\021\024-\n\t\001\036\004\027\024\020\024 )0.5(\035\024\f\022\031\021\026 )0.5(\(\214\230)]TJ /Span<>> BDC ( )Tj EMC (+)Tj /Span<>> BDC ( )Tj EMC (\221\204\214\), \r\024 )Tj 0.155 Tw T* (\r\021\024\030\024\005 \020\030\031\023\023\036 \023\030\024\017\r\024\007\ \017\035\026\f\034 \035\026\036\030\027\026\016 \022\024\026\020\031\035\ \016\006\017\016, )Tj 0.382 Tw T* (\007\024\023\024\035\027\036\027\027\026\016 \023\036\030\036\r\016\022\ \024\005 \f\r\017\013\036\r\024\020\024 \b\024\007\026 \r)Tj /Span<>> BDC ( )Tj EMC (\n\036\032)Tj 0 Tw (-)Tj 0.084 Tw T* (\f\235\017\027\022\021\036\030\027\024\n \023\030\024\f\021\030\026\027\f\ \021\r\036 \(\214\230)Tj /Span<>> BDC ( )Tj EMC (+)Tj /Span<>> BDC ( )Tj EMC (\215\221\204\215\) [14]. \230\026\022\017\n )Tj -0.03 Tw T* (\024\002\030\026\024\n, \r)Tj /Span<>> BDC ( )Tj EMC (\203\204\222\037 \022\024\035\024\023\030\024\022\021\024\035\024\020\017\ \017 \017\n\036\027\017 \202.\203.)Tj /Span<>> BDC ( )Tj EMC (\217\t\032\017\b )Tj 0.053 Tw 0 -1.218 TD [(\002\t\035 \027\026\022\024\023\035\036\027 )0.5(\024\023\t\021 \023\030\017\n\036\027\036\027\017\016 )0.5(\024\023\036\030\026\006\017\005, )0.5(\023\030\017)]TJ /Span<>> BDC ( )Tj EMC (\022\024\021\024)Tj 0 Tw (-)Tj 0.052 Tw 0 -1.218 TD (\030\t\b \r\t\023\024\035\027\016\035\026\f\034 \022\024\026\020\031\035\ \016\006\017\016 \f\021\036\027\024\022 \f\r\017\013\036\r\024\020\024 \b\ \024\007\026 )Tj -0.015 Tw T* (\007\017\024\007\027\t\n \035\026\036\030\024\n \f)Tj /Span<>> BDC ( )Tj EMC (3 \030\026\035\017\004\027\t\n\017 \r\026\030\017\026\027\021\026\n\017\ \026\022\030\t)Tj 0 Tw (-)Tj T* (\021\017\016 \r\027\031\021\030\036\027\027\036\020\024 \f\r\017\013\036\ \r\024\020\024 \024\021\r\036\030\f\021\017\016.)Tj 0.072 Tw T* [(\025\030\017\021\036\030\017\016\n\017 )0.6(\r\022\035\033\004\036\027\017\016 )0.6(\023\026\006\017\036\027\021\024\r )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 15.544 0 Td (\017\f\f\035\036\007\024\r\026\027\017\036)Tj /Span<>> BDC ( )Tj EMC 6.066 0 Td (1 )Tj 0.185 Tw -21.61 -1.218 Td (\002\t\035\017: \021\030\026\027\f\f\235\017\027\022\021\036\030\027\t\005\ \f\r\017\013, \220\022\f\021\030\026\f\235\017\027\022\021\036\030\027\t\ \005 )Tj 0.143 Tw 0 -1.218 TD (\f\r\017\013 \023\030\016\n\024\005 \022\017\001\022\017 1\2262)Tj /Span<>> BDC ( )Tj EMC (\f\021\036\023\036\027\017 \f\035\024\032\027\024\f\021\017; \024\021\f\031\ \021)Tj 0 Tw (-)Tj 0.185 Tw 0 -1.218 TD [(\f\021\r\017\036 )0.5(\031)]TJ /Span<>> BDC ( )Tj EMC 3.556 0 Td [(\023\026\006\017\036\027\021\026 )0.6(\020\035\031\002\024\022\017\b )0.5(\026\021\036\022\024\r )0.5(\023\024)]TJ /Span<>> BDC ( )Tj EMC 13.373 0 Td [(\b\024\007\031 )0.5(\f\r\017\013\026; )]TJ 0.037 Tw -16.929 -1.218 Td (\024\021\f\031\021\f\021\r\017\036 \r)Tj /Span<>> BDC ( )Tj EMC (\026\027\026\n\027\036\036 \030\026\007\017\022\026\035\034\027\t\b \024\ \023\036\030\026\006\017\005 \023\024)Tj /Span<>> BDC ( )Tj EMC (\023\024)Tj 0 Tw (-)Tj 0.155 Tw 0 -1.218 TD (\r\024\007\031 \f\r\017\013\026 \023\030\016\n\024\005 \022\017\001\022\017\ . \200)Tj /Span<>> BDC ( )Tj EMC (\017\f\f\035\036\007\024\r\026\027\017\036 2 \002\t\035\017 )Tj -0.009 Tw T* [(\r\022\035\033\004\036\027\t )0.6(\023\026\006\017\036\027\021\t )0.5(\021\024\035\034\022\024 )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC 12.2 0 Td [(\021\030\026\027\f\f\235\017\027\022\021\036\030\027\t\n )0.6(\030\026\f)]TJ 0 Tw (-)Tj -12.2 -1.218 Td (\023\024\035\024\032\036\027\017\036\n \f\r\017\013\036\r\024\020\024 \b\ \024\007\026.)Tj 0.001 Tw T* (\025\030\017\021\036\030\017\016\n\017 \027\036\r\022\035\033\004\036\027\ \017\016 \r)Tj /Span<>> BDC ( )Tj EMC (\017\f\f\035\036\007\024\r\026\027\017\016 \002\t\035\017: \f\r\017)Tj 0 Tw (-)Tj 0.014 Tw T* (\013\017 \027\026)Tj /Span<>> BDC ( )Tj EMC (\235\024\027\036 \r\024\f\023\026\035\017\021\036\035\034\027\t\b \026\002\ \024\035\036\r\026\027\017\005 \022\017\001\036\004\027\017\022\026 )Tj 0.209 Tw T* (\(\016\r\036\027\027\t\005 \022\024\035\017\021, \002\024\035\036\027\034\ \025\030\024\027\026\), \024\027\022\024\035\024\020\017\004\036\f\022\024\ \020\024 )Tj 0.495 Tw T* [(\023\030\024\006\036\f\f\026, \f\023\036\006\017\235\017\004\036\f\022\026\ \016 )0.5(\220\021\017\024\035\024\020\017\016 \f\r\017\013\036\005 \(\021\031)]TJ 0 Tw (-)Tj 0.235 Tw T* [(\002\036\030\022\031\035\036, \026\022\021\017\027\024\n\017\022\024\)\ . )0.5(\210\023\036\030\026\006\017\016 \027\036 \r\t\023\024\035\027\016\035\026\ \f\034 )]TJ 0.079 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\f\035\031\004\026\036 \027\026\035\017\004\017\016 \023\024)Tj /Span<>> BDC ( )Tj EMC (\b\024\007\031 \f\r\017\013\026 \020\035\031\002\024\022\017\b \(\023\036\ \035\034\r\017\024)Tj 0 Tw (-)Tj 0.106 Tw T* (\030\036\022\021\026\035\034\027\t\005, \030\036\021\030\024\030\036\022\ \021\026\035\034\027\t\005\) \026\021\036\022\024\r. \223\026\f\021\017\ \023\026\006\017)Tj 0 Tw (-)Tj 0.103 Tw T* (\036\027\021\024\r \007\035\016 \023\024\007\020\024\021\024\r\022\017 \022\ )Tj /Span<>> BDC ( )Tj EMC (\035\026\036\030\027\024\005 \022\024\026\020\031\035\016\006\017\017 \f\ \r\017\013\026 )Tj 0.023 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\022\026\004\036\f\021\r\036 1-\020\024 \220\021\026\023\026 \035\036\004\ \036\027\017\016 \023\030\024\017\r\024\007\017\035\024\f\034 \r\f\022\030\ \t)Tj 0 Tw (-)Tj 0.005 Tw T* (\021\017\036 \017)Tj /Span<>> BDC ( )Tj EMC 2.358 0 Td [(\007\030\036\027\017\030\024\r\026\027\017\036 )0.5(\026\021\036\022\024\r \f)]TJ /Span<>> BDC ( )Tj EMC 10.25 0 Td [(\023\030\024\r\036\007\036\027\017\036\n )0.5(\007\030\036\027\017\030\031)]TJ 0 Tw (-)Tj 0.133 Tw -12.608 -1.218 Td (\033\013\036\005 \035\026\021\036\022\f\027\024\005 \035\017\020\026\021\ \031\030\t. \200\021\024\030\024\005 \220\021\026\023 \r\t\023\024\035\027\ \016\035\f\016 )Tj 0 Tw T* (\004\036\030\036 1\2263)Tj /Span<>> BDC ( )Tj EMC (\n\036\f\016\006\026 \023\024\f\035\036 \023\030\024\r\036\007\036\027\017\ \016 \035\017\020\026\021\031\030\t.)Tj -0.028 Tw T* [(\200 )0.5(\024\002\024\017\b )0.5(\017\f\f\035\036\007\024\r\026\027\017\016\b )0.5(\017\f\023\024\035\034\024\r\026\035\026\f\034 )0.5(\n\024\013\027\024\f\021\034 )0.5(\017)]TJ 0 Tw (-)Tj 0.058 Tw T* (\035\031\004\036\027\017\016 \035\026\036\030\026, \f\024\f\021\026\r\035\ \016\033\013\026\016 12 \200\021 \f)Tj /Span<>> BDC ( )Tj EMC (\027\036\023\030\036\030\t\r\027\t\n )Tj 0.132 Tw T* [(\030\036\032\017\n\024\n )0.5(\030\026\002\024\021\t )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC 8.365 0 Td [(\f\022\024\030\024\f\021\034\033 )0.6(\r\t\r\036\007\036\027\017\016 )0.6(\f\r\036\021\024\r\024\007\026 )]TJ 0.063 Tw -8.365 -1.218 Td (\023\024)Tj /Span<>> BDC ( )Tj EMC (\022\026\027\026\035\031 \f\r\017\013\026 \251 1 \n\n/\f\036\022\031\027\ \007\031. \211)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r, \022\024\021\024)Tj 0 Tw (-)Tj 0.071 Tw T* (\030\t\n \r\t\023\024\035\027\016\035\026\f\034 \035\026\036\030\027\026\ \016 \022\024\026\020\031\035\016\006\017\016 \f)Tj /Span<>> BDC ( )Tj EMC (\031\001\017\r\026\027\017\036\n )Tj 0.087 Tw T* (\r\027\031\021\030\036\027\027\036\020\024 \f\r\017\013\036\r\024\020\024\ \024\021\r\036\030\f\021\017\016 \(\214\230)Tj /Span<>> BDC ( )Tj EMC (+)Tj /Span<>> BDC ( )Tj EMC (\211\200\210\), \026)Tj /Span<>> BDC ( )Tj EMC (\021\026\022)Tj 0 Tw (-)Tj 0.008 Tw T* (\032\036 \023\026\006\017\036\027\021\024\r, \r\b\024\007\016\013\017\b \ \r)Tj /Span<>> BDC ( )Tj EMC (\017\f\f\035\036\007\024\r\026\027\017\036 1, \031)Tj /Span<>> BDC ( )Tj EMC (\022\024\021\024\030\t\b )Tj 0.068 Tw T* [(\023\030\024\017\r\024\007\017\035\024\f\034 \026\022\030\t\021\017\036\ )0.5(\r\027\031\021\030\036\027\027\036\020\024 \f\r\017\013\036\r\024\020\024\ \024\021)]TJ 0 Tw (-)Tj 0.366 Tw T* (\r\036\030\f\021\017\016 \n\036\021\024\007\024\n \027\017\r\036\007\036\ \027\017\016 \f\035\017\017\f\021\024-\n\t\001\036\004\027\024\020\024 \ )Tj 0.21 Tw T* (\035\024\f\022\031\021\026 \(\214\230)Tj /Span<>> BDC ( )Tj EMC (+)Tj /Span<>> BDC ( )Tj EMC (\221\204\214\), \017\f\023\024\035\034\024\r\026\035\f\016 \007\017\024\ \007\027\t\005 \035\026\036\030 )Tj -0.028 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\007\035\017\027\024\005 \r\024\035\027\t 1470 \027\n \(\026\023\023\026\ \030\026\021 \035\026\036\030\027\t\005 \n\036\007\017\006\017\027)Tj 0 Tw (-)Tj -0.019 Tw T* (\f\022\017\005 \253\202\221\230\273, \217\024\f\f\017\016\). \200)Tj /Span<>> BDC ( )Tj EMC (\017\f\f\035\036\007\024\r\026\027\017\017 2 \r\024 \r\f\036\b \f\035\031\ \004\026)Tj 0 Tw (-)Tj -0.013 Tw T* [(\016\b \023\030\017\n\036\027\016\035\f\016 \007\017\024\007\027\t\005 )0.5(\035\026\036\030 \253\222\217\224-\023\024\035\033\f\273 )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC (\007\035\017\027\024\005 )Tj 0.119 Tw T* [(\r\024\035\027\t )0.5(1560 )0.6(\027\n. )0.5(\230\036\b\027\017\022\026 )0.5(\024\023\036\030\026\021\017\r\027\t\b )0.6(\r\n\036\001\026\021\036\035\034\f\021\r )]TJ 0 Tw T* (\023\024\007\030\024\002\027\024 \023\030\036\007\f\021\026\r\035\036\027\ \026 \r)Tj /Span<>> BDC ( )Tj EMC (\f\021\026\021\034\016\b [13,14].)Tj 0.057 Tw T* (\221 \006\036\035\034\033 \024\006\036\027\022\017 \024\f\024\002\036\027\ \027\024\f\021\036\005 \030\026\f\023\024\035\024\032\036\027\017\016 \f\ \r\017\013\036)Tj 0 Tw (-)Tj 0.052 Tw T* (\r\024\020\024 \b\024\007\026 \017)Tj /Span<>> BDC ( )Tj EMC (\036\020\024 \b\026\030\026\022\021\036\030\017\f\021\017\022, \024\023\030\ \036\007\036\035\036\027\017\016 \035\024\022\026\035\017)Tj 0 Tw (-)Tj 0.053 Tw T* (\026\006\017\017 \017)Tj /Span<>> BDC ( )Tj EMC (\007\017\026\n\036\021\030\026 \r\027\031\021\030\036\027\027\036\020\024\ \f\r\017\013\036\r\024\020\024 \024\021\r\036\030\f\021\017\016, )Tj -0.057 Tw T* (\r\t\016\r\035\036\027\017\016 \026\021\036\022\024\r \017)Tj /Span<>> BDC ( )Tj EMC (\r\021\024\030\017\004\027\t\b \f\r\017\013\036\r\t\b \b\024\007\024\r \r\ \f\036\n )Tj -0.048 Tw T* (\023\026\006\017\036\027\021\026\n \007\024)Tj /Span<>> BDC ( )Tj EMC (\024\023\036\030\026\006\017\017 \r\t\023\024\035\027\016\035\024\f\034 \ \220\027\007\024\030\036\022\021\026\035\034\027\024\036 )Tj 0.324 Tw T* (\031\035\034\021\030\026\r\031\022\024\r\024\036 \017\f\f\035\036\007\024\ \r\026\027\017\036 \(\224\217\211\003\222\). \200\024 \n\027\024\020\024\ \n )Tj 0 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC (\024\f\027\024\r\026\027\017\017 \030\036\031\035\034\021\026\021\024\r\ \224\217\211\003\222 \024\023\030\036\007\036\035\016\035\017\f\034 \023\ \024\022\026)Tj (-)Tj 0.158 Tw T* (\026\027\017\016 \022)Tj /Span<>> BDC ( )Tj EMC (\r\024\n\024\032\027\024\f\021\017 \r\t\023\024\035\027\036\027\017\016\ \f\235\017\027\022\021\036\030\024\f\002\036\030\036)Tj 0 Tw (-)Tj -0.025 Tw T* (\020\026\033\013\036\005 \024\023\036\030\026\006\017\017 \f)Tj /Span<>> BDC ( )Tj EMC (\017\f\023\024\035\034\024\r\026\027\017\036\n \007\017\024\007\027\024\ \020\024 \035\026\036\030\026 )Tj 0.024 Tw 23.244 64.543 Td [(\007\035\016 )0.5(\035\036\004\036\027\017\016 )0.5(\f\035\024\032\027\t\b )0.5(\f\r\017\013\036\005. )0.6(\200)]TJ /Span<>> BDC ( )Tj EMC 13.678 0 Td (\023\024\f\035\036\024\023\036\030\026\006\017\024\027\027\024\n )Tj 0.006 Tw -13.678 -1.218 Td (\023\036\030\017\024\007\036, \f)Tj /Span<>> BDC ( )Tj EMC (\006\036\035\034\033 \024\006\036\027\022\017 \023\030\024\006\036\f\f\026\ \026\032\017\r\035\036\027\017\016 \030\026\027\t, )Tj 0.268 Tw T* [(\022\026\027\026\035\026 )0.5(\f\r\017\013\026 )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC 7.424 0 Td [(\r\027\031\021\030\036\027\027\036\020\024 )0.6(\f\r\017\013\036\r\024\020\024 )0.5(\024\021\r\036\030\f\021\017\016 )]TJ 0.014 Tw -7.424 -1.218 Td (\022\024\027\021\030\024\035\034\027\t\036 \224\217\211\003\222 \023\030\ \024\017\r\024\007\017\035\017\f\034 \004\036\030\036 1 \017)Tj /Span<>> BDC ( )Tj EMC (2 \n\036\f\016)Tj 0 Tw (-)Tj T* (\006\026 \023\024\f\035\036 \024\023\036\030\026\006\017\017 \(\217\017\f\ . 1\2262\).)Tj 0.493 Tw T* (\200 \022\026\004\036\f\021\r\036 \023\030\017\n\036\030\026 \023\030\017\ \r\024\007\017\n \007\r\026 \022\035\017\027\017\004\036\f\022\017\b )Tj 0 Tw 0 -1.218 TD (\f\035\031\004\026\016.)Tj 0.198 Tw 0 -1.218 TD (\200 \023\036\030\r\024\n \f\035\031\004\026\036 \(\217\017\f.)Tj /Span<>> BDC ( )Tj EMC (1\) \023\030\036\007\f\021\026\r\035\036\027\026 \f\036\030\017\016 \220\ \b\024)Tj 0 Tw (-)Tj 0.331 Tw T* (\020\030\026\n\n \027\026)Tj /Span<>> BDC ( )Tj EMC (\030\026\027\t\b \220\021\026\023\026\b \b\017\030\031\030\020\017\004\036\ \f\022\024\020\024 \035\036\004\036\027\017\016. )Tj 0.646 Tw T* (\203\026)Tj /Span<>> BDC ( )Tj EMC (\030\017\f\031\027\022\036 1\202 \023\030\024\007\036\n\024\027\f\021\030\ \017\030\024\r\026\027\026 \220\b\024\020\030\026\n\n\026 )Tj 0.318 Tw T* (\026\007\027\036\020\024 \021\030\026\027\f\f\235\017\027\022\021\036\030\ \027\024\020\024 \f\r\017\013\026 \023\030\016\n\024\005 \022\017\001\022\ \017. )Tj 0.031 Tw T* (\200\027\031\021\030\036\027\027\036\036 \f\r\017\013\036\r\024\036 \024\ \021\r\036\030\f\021\017\036 \030\026\f\023\024\035\024\032\036\027\024 \ \r)Tj /Span<>> BDC ( )Tj EMC (\023\030\024)Tj 0 Tw (-)Tj -0.033 Tw 0 -1.218 TD (\036\022\006\017\017 \026\007\027\036\005 \026\027\026\035\034\027\024\005\ \022\030\017\023\021\t, \017\n\036\036\021 \007\017\026\n\036\021\030 2\ ,5)Tj /Span<>> BDC ( )Tj EMC (\n\n, )Tj 0.022 Tw 0 -1.218 TD (\024\021 \024\021\r\036\030\f\021\017\016 \004\036\030\036 \023\024\r\036\ \030\b\027\024\f\021\027\031\033 \023\024\030\006\017\033 \027\026\030\031\ \032\027\024)Tj 0 Tw (-)Tj -0.001 Tw 0 -1.218 TD (\020\024 \f\235\017\027\022\021\036\030\026 \017\007\036\021 \023\030\016\ \n\024\035\017\027\036\005\027\t\005 \026\027\220\b\024\020\036\027\027\t\ \005 \f\r\017)Tj 0 Tw (-)Tj -0.042 Tw T* (\013\036\r\024\005 \b\024\007 \023\030\024\021\016\032\036\027\027\024\f\ \021\034\033 35 \n\n, \001\017\030\017\027\024\005 \007\024)Tj /Span<>> BDC ( )Tj EMC (3,7)Tj /Span<>> BDC ( )Tj EMC (\n\n, )Tj 0.8 Tw T* (\022\024\021\024\030\t\005 \007\030\036\027\017\030\031\036\021\f\016 \027\ \026)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\017\026\027\026\035\034\027\031\033 \022\024\032\031. )Tj 0.238 Tw T* (\212\026\027\027\024\n\031 \023\026\006\017\036\027\021\031 \r\t\023\024\ \035\027\036\027\024 \024\023\036\030\026\021\017\r\027\024\036 \r\n\036\ \001\026)Tj 0 Tw (-)Tj 0.137 Tw T* (\021\036\035\034\f\021\r\024 \r)Tj /Span<>> BDC ( )Tj EMC (\024\002\255\036\n\036 \214\025)Tj /Span<>> BDC ( )Tj EMC (+)Tj /Span<>> BDC ( )Tj EMC (\215\221\204\215. \215\024\f\035\036\024\023\036\030\026\006\017\024\027\ \027\t\005 )Tj 0.142 Tw T* (\023\036\030\017\024\007 \023\030\024\021\036\022\026\035 \002\036 \024\ \f\035\024\032\027\036\027\017\005. \215\030\017)Tj /Span<>> BDC ( )Tj EMC (\r\t\023\024\035\027\036\027\017\017 )Tj 0.143 Tw T* (\022\024\027\021\030\024\035\034\027\024\020\024 \224\217\211\003\222 \004\ \036\030\036 1 \n\036\f\016\006 \023\024\f\035\036 \024\023\036\030\026\ \006\017\017 )Tj 0.307 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC (\220\b\024\020\030\026\n\n\036 \r\027\031\021\030\036\027\027\036\036 \f\ \r\017\013\036\r\024\036 \024\021\r\036\030\f\021\017\036 \024\021)Tj 0 Tw (-)Tj 0.276 Tw T* (\004\036\021\035\017\r\024 \027\036 \r\017\031\026\035\017\017\030\031\ \036\021\f\016 \(\217\017\f.)Tj /Span<>> BDC ( )Tj EMC (1\207\). \203\026)Tj /Span<>> BDC ( )Tj EMC (\031\030\024\r\027\036 )Tj -0.003 Tw T* (\n\036\032\f\235\017\027\022\021\036\030\027\024\020\024 \023\030\024\f\021\ \030\026\027\f\021\r\026, \r)Tj /Span<>> BDC ( )Tj EMC (\024\027\036 \030\026\027\036\036 \r\t\023\024\035)Tj 0 Tw (-)Tj 0.03 Tw T* (\027\036\027\027\024\005 \023\036\030\036\r\016\022\017 \f\r\017\013\036\ \r\024\020\024 \b\024\007\026 \024\023\030\036\007\036\035\016\033\021\f\ \016 \035\024)Tj 0 Tw (-)Tj 0.132 Tw T* (\022\026\035\034\027\t\036 \002\036\f\235\024\030\n\036\027\027\t\036 \021\ \022\026\027\017 \f\030\036\007\027\036\005 \220\b\024\020\036\027\027\024\ \f\021\017, )Tj 0.081 Tw T* [(\002\036 )0.5(\032\017\007\022\024\f\021\027\t\b )0.6(\r\022\035\033\004\036\027\017\005. )0.5(\200)]TJ /Span<>> BDC ( )Tj EMC 13.085 0 Td [(\023\030\024\036\022\006\017\017 )0.5(\007\017\f\021\026\035\034\027\024\005 )]TJ 0.155 Tw -13.085 -1.218 Td (\004\026\f\021\017 \f\r\017\013\026 \024\023\030\036\007\036\035\016\033\ \021\f\016 \036\007\017\027\017\004\027\t\036 \026\027\220\b\024\020\036\ \027\027\t\036 )Tj 0.204 Tw T* (\032\017\007\022\024\f\021\027\t\036 \r\022\035\033\004\036\027\017\016,\ \004\021\024 \n\024\032\036\021 \f\024\024\021\r\036\021\f\021\r\024\r\026\ \021\034 )Tj 0.024 Tw T* (\027\036\023\024\035\027\024\005 \024\002\035\017\021\036\030\026\006\017\ \017 \f\r\017\013\026. \215\030\017)Tj /Span<>> BDC ( )Tj EMC (\023\024\r\021\024\030\027\024\n \224\217\211\003\222 )Tj 0.089 Tw T* (\004\036\030\036 2 \n\036\f\016\006\026 \(\217\017\f.)Tj /Span<>> BDC ( )Tj EMC (1\200\) \r)Tj /Span<>> BDC ( )Tj EMC (\024\027\036 \030\026\027\036\036 \023\030\024\r\036\007\036\027\027\024\ \005 )Tj -0.022 Tw T* (\024\023\036\030\026\006\017\017 \r\t\016\r\035\036\027\024 \f\024\b\030\ \026\027\036\027\017\036 \020\017\023\024\220\b\024\020\036\027\027\024\020\ \024 \021\016\032\026 )Tj 0.179 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\027\026\035\017\004\017\036\n \020\017\023\036\030\220\b\024\020\036\027\ \027\t\b \r\022\035\033\004\036\027\017\005 \r)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\f\r\036\021\036, )Tj 0.138 Tw T* (\004\021\024 \f\r\017\007\036\021\036\035\034\f\021\r\024\r\026\035\024 \ \024)Tj /Span<>> BDC ( )Tj EMC (\r\024\n\024\032\027\024\f\021\017 \030\026\r\017\021\017\016 \030\036\ )Tj 0 Tw (-)Tj 0.114 Tw T* [(\006\017\007\017\r\026 )0.5(\f\r\017\013\026. \210\007\027\026\022\024 )0.5(\023\030\017)]TJ /Span<>> BDC ( )Tj EMC [(\022\035\017\027\017\004\036\f\022\024\n )0.5(\024\f\n\024\021\030\036 )0.5(\f\024 )]TJ 0.263 Tw T* (\f\021\024\030\024\027\t \023\036\030\017\026\027\026\035\034\027\024\005\ \022\024\032\017 \024\023\030\036\007\036\035\016\035\f\016 \023\035\024\ \f\022\017\005 )Tj 0.18 Tw T* (\030\031\002\036\006, \002\036 \023\030\017\027\026\022\024\r \r\024\f\ \023\026\035\036\027\017\016. \212\026\027\027\t\005 \023\026\006\017\036\ \027\021 )Tj 0.244 Tw T* [(\027\026\b\024\007\017\035\f\016 \023\024\007 \007\017\027\026\n\017\004\ \036\f\022\017\n )0.5(\027\026\002\035\033\007\036\027\017\036\n. \223\036\030\036 )]TJ -0.033 Tw T* (6)Tj /Span<>> BDC ( )Tj EMC (\n\036\f\016\006\036\r \023\024\f\035\036 \024\023\036\030\026\021\017\r\ \027\024\020\024 \r\n\036\001\026\021\036\035\034\f\021\r\026 \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017)Tj 0 Tw (-)Tj -0.016 Tw T* [(\036\027\021\026 \023\030\024\017\024\001\035\024 \f\026\n\024\023\030\024\ \017\r\024\035\034\027\024\036 )0.5(\r\f\022\030\t\021\017\036 \024\f\021\030\024\020\024 )]TJ 0.193 Tw T* (\023\026\030\026\023\030\024\022\021\017\021\026, \002\t\035 \007\017\026\ \020\027\024\f\021\017\030\024\r\026\027 \030\036\006\017\007\017\r \f\r\ \017\013\026. )Tj 0.303 Tw T* (\200)Tj /Span<>> BDC ( )Tj EMC [(\023\024\f\035\036\007\031\033\013\036\n \r\t\023\024\035\027\036\027\026\ \030\026\007\017\022\026\035\034\027\026\016 )0.5(\024\023\036\030\026\006\017\016 )]TJ 0 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\024\002\255\036\n\036 \017\f\f\036\004\036\027\017\016 \f\r\017\013\026\ \f)Tj /Span<>> BDC ( )Tj EMC (\031\001\017\r\026\027\017\036\n \f\235\017\027\022\021\036\030\026.)Tj 0.355 Tw T* (\200 \022\026\004\036\f\021\r\036 2-\020\024 \022\035\017\027\017\004\036\ \f\022\024\020\024 \023\030\017\n\036\030\026 \023\030\036\007\f\021\026\ \r)Tj 0 Tw (-)Tj 0.285 Tw T* (\035\036\027\026 \f\036\030\017\016 \220\b\024\020\030\026\n\n \f)Tj /Span<>> BDC ( )Tj EMC (\022\035\017\027\017\022\024-\017\027\f\021\030\031\n\036\027\021\026\035\ \034\027\024\005 )Tj 0.204 Tw T* (\022\026\030\021\017\027\024\005 \026\032\017\r\035\036\027\017\016 \f\r\ \017\013\026. \203\026)Tj /Span<>> BDC ( )Tj EMC (\030\017\f\031\027\022\036 2\202 \023\030\036\007)Tj 0 Tw (-)Tj 0.688 Tw T* (\f\021\026\r\035\036\027\026 \220\b\024\020\030\026\n\n\026 \026\007\027\ \036\020\024 \021\030\026\027\f\f\235\017\027\022\021\036\030\027\024\020\ \024 )Tj 0.169 Tw T* (\f\r\017\013\026, \017\007\031\013\036\020\024 \004\036\030\036 \020\035\ \031\002\024\022\031\033 \023\024\030\006\017\033 \027\026\030\031\032\027\ \024\020\024 )Tj 0.231 Tw T* [(\f\235\017\027\022\021\036\030\026. \212\026\027\027\024\n\031 )0.5(\023\026\006\017\036\027\021\031 \r\t\023\024\035\027\016\035\024\f\034 \ \026\027\026\035\024)]TJ 0 Tw (-)Tj 0.365 Tw T* (\020\017\004\027\024\036 \024\023\036\030\026\021\017\r\027\024\036 \r\n\ \036\001\026\021\036\035\034\f\021\r\024 \(\214\230)Tj /Span<>> BDC ( )Tj EMC (+)Tj /Span<>> BDC ( )Tj EMC (\215\221\204\215\), )Tj 0.407 Tw T* (\023\024\f\035\036\024\023\036\030\026\006\017\024\027\027\t\005 \023\036\ \030\017\024\007 \023\030\024\021\036\022\026\035 \002\036 \024\f\035\024\ \032)Tj 0 Tw (-)Tj 0.234 Tw T* [(\027\036\027\017\005. )0.5(\215\030\017)]TJ /Span<>> BDC ( )Tj EMC 5.375 0 Td [(\022\024\027\021\030\024\035\034\027\024\n )0.5(\r\t\023\024\035\027\036\027\017\017 )0.5(\224\217\211\003\222 )0.6(\004\036\030\036 )]TJ 0.061 Tw -5.375 -1.218 Td (1)Tj /Span<>> BDC ( )Tj EMC (\n\036\f\016\006 \r)Tj /Span<>> BDC ( )Tj EMC (\024\027\036 \024\023\036\030\026\021\017\r\027\024\020\024 \r\n\036\001\ \026\021\036\035\034\f\021\r\026 \007\017\235\235\036)Tj 0 Tw (-)Tj 0.202 Tw T* (\030\036\027\006\017\030\031\036\021\f\016 \023\030\036\030\t\r\017\f\021\ \t\005 \f\r\017\013\036\023\024\007\024\002\027\t\005 \021\016\032 \002\036\  )Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0 Tw 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\033\030\031\030\213\b)-20.9(\035\231\213\233\t \021\032)50(\b)42(\032\231\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj -51.938 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 23, \023\0221)69(, 202)69(4)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 23, \023\0221)69(, 202)69(4)]TJ /T1_2 1 Tf 25 0 0 25 28.115 56.0378 Tm (62)Tj ET endstream endobj 1922 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\034\205\026\220\007\016\026\001\220\203 \025\221\020\026 \221\002\220\024\ \016\001\016\001\220\205 \024\016\026)11.1(\025\201\013 \007\013\222\016\002\001\025\203 \n)10(\025\013\202)-20(\215\007\205\227\220\220 )]TJ 0 -1 TD [(\221\002\220\022\007\016\017\016\001\220\220 \026\002\013\001\006- \220\022\ \232\n\006)-10(\026\002\013\006\225\220\001\n)-9.9(\026)11(\016\002\001\020\207 \006\r\220\224\016\203 \221\002\205\024\025\203 \n\220\ \n\220)]TJ 37.587 1 Td [(Fiv)12(e)-52(-y)10(ear e)21(xperience of laser coagulation in th)11(e tr)31(eatment )]TJ 6.214 -1 Td [(of tr)21.1(ans- and supr)21.1(asphincteric anal f)-20.9(istulas)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0.09 Tw 10 0 0 10 42.5197 724.8299 Tm (\r\t\023\024\035\027\016\035\024\f\034 \r\f\022\030\t\021\017\036 \026\021\ \036\022\024\r, \026)Tj /Span<>> BDC ( )Tj EMC (\f \023\024\n\024\013\034\033 \035\026\036\030\026 )Tj 0.05 Tw 0 -1.218 TD [(\024\002\030\026\002\026\021\t\r\026\035\026\f\034 )0.6(\004\026\f\021\034 )0.5(\f\r\017\013\026, )0.5(\023\030\024\b\024\007\016\013\026\016 )0.6(\004\036\030\036 )0.6(\021\024\035)]TJ 0 Tw (-)Tj 0.05 Tw T* (\013\031 \026\027\026\035\034\027\024\020\024 \f\235\017\027\022\021\036\ \030\026 / \f\021\036\027\022\031 \023\030\016\n\024\005 \022\017\001\022\ \017 [9]. )Tj 0.04 Tw T* (\210\021\027\024\f\017\021\036\035\034\027\024 \023\030\024\f\r\036\021\026\ \f\r\017\013\036\r\024\020\024 \b\024\007\026 \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\006\036\f\f\024\r, )Tj 0.065 Tw T* (\023\030\024\017\f\b\024\007\016\013\017\b \r)Tj /Span<>> BDC ( )Tj EMC (\021\022\026\027\016\b, \024\022\030\031\032\026\033\013\017\b \f\r\017\013\ , \r)Tj /Span<>> BDC ( )Tj EMC (\030\026\002\024\021\036 )Tj -0.032 Tw T* (\204\026\021\017\027\016\027\026 \202.\200., \025\024\f\021\026\030\036\r\ \026 \222.\200. \f)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. \(2021\), \r\t\023\024\035)Tj 0 Tw (-)Tj 0.046 Tw 0 -1.218 TD [(\027\036\027\027\024\005 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC [(\203\204\222\037 \022\024\035\024\023\030\024\022\021\024\035\024\020\017\ \017 )0.5(\017\n\036\027\017 )0.5(\202.\203.)]TJ /Span<>> BDC ( )Tj EMC (\217\t\032\017\b, )Tj 0.244 Tw 0 -1.218 TD (\002\t\035\024 \031\f\021\026\027\024\r\035\036\027\024, \004\021\024 \023\ \024\035\027\024\005 \024\002\035\017\021\036\030\026\006\017\017 \f\r\017\ \013\026 )Tj 0.114 Tw T* (\023\024\007 \007\036\005\f\021\r\017\036\n \035\026\036\030\027\024\005\ \022\024\026\020\031\035\016\006\017\017 \027\036 \023\030\024\017\f\b\024\ \007\017\021, )Tj 0.146 Tw T* (\027\036\022\030\024\021\017\004\036\f\022\017\036 \017\n\036\027\036\027\ \017\016 \021\022\026\027\036\005 \f\021\036\027\024\022 \f\r\017\013\036\ \r\024\020\024 )Tj 0.008 Tw T* (\b\024\007\026 \023\024)Tj /Span<>> BDC ( )Tj EMC (\024\022\030\031\032\027\024\f\021\017 \017\n\036\033\021 \027\036\030\026\ \r\027\024\n\036\030\027\t\005 \b\026\030\026\022\021\036\030, )Tj -0.005 Tw T* (\026)Tj /Span<>> BDC ( )Tj EMC (\020\035\031\002\017\027\026 \027\036\022\030\024\026 \022\024\035\036\002\ \035\036\021\f\016 \024\021 0,5 \007\024)Tj /Span<>> BDC ( )Tj EMC (2 \n\n [10]. \224\021\017 )Tj 0.111 Tw 0 -1.218 TD [(\007\026\027\027\t\036 )0.5(\007\036\n\024\027\f\021\030\017\030\031\033\021 )0.6(\r\024\n\024\032\027\024\f\021\034 )0.5(\017\f\023\024\035\034\024\r\026\027\017\016 )]TJ -0.022 Tw 0 -1.218 TD (\n\036\021\024\007\017\022\017 \r)Tj /Span<>> BDC ( )Tj EMC (\024\f\027\024\r\027\024\n \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\023\030\016\n\024\035\017\027\036\005\027\t\n\017 )Tj 0.12 Tw 0 -1.218 TD (\f\r\017\013\026\n\017, \002\036 \020\035\031\002\024\022\017\b \026\021\ \036\022\024\r \017)Tj /Span<>> BDC ( )Tj EMC (\r\021\024\030\017\004\027\t\b \f\r\017\013\036)Tj 0 Tw (-)Tj -0.02 Tw T* (\r\t\b \b\024\007\024\r. \200)Tj /Span<>> BDC ( )Tj EMC (\f\035\031\004\026\036 \027\026\035\017\004\017\016 \023\026\030\026\030\ \036\022\021\026\035\034\027\t\b \026\021\036\022\024\r )Tj 0.207 Tw T* (\030\036\022\024\n\036\027\007\031\036\021\f\016 \017\b \r\f\022\030\t\021\ \017\036 \f)Tj /Span<>> BDC ( )Tj EMC (\031\f\021\026\027\024\r\022\024\005 \007\030\036\027\017\030\031)Tj 0 Tw (-)Tj 0.142 Tw T* (\033\013\036\005 \035\026\021\036\022\f\027\024\005 \035\017\020\026\021\ \031\030\t. \214\036\004\036\027\017\036 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\n \027\024\f\017\021 )Tj 0 Tw T* (\n\027\024\020\024\220\021\026\023\027\t\005 \b\026\030\026\022\021\036\030\ .)Tj 0.376 Tw T* (\203\026\017\002\024\035\034\001\017\005 \017\027\021\036\030\036\f \023\ \030\036\007\f\021\026\r\035\016\036\021 \027\036\024\002\b\024\007\017\n\ \024\f\021\034 )Tj 0.334 Tw T* (\026\022\030\t\021\017\016 \017)Tj /Span<>> BDC ( )Tj EMC (\r\t\002\024\030 \f\023\024\f\024\002\026 \026\022\030\t\021\017\016 \r\ \027\031\021\030\036\027\027\036\020\024 )Tj 0.411 Tw T* (\f\r\017\013\036\r\024\020\024 \024\021\r\036\030\f\021\017\016. \212\026\ \027\027\026\016 \023\030\024\002\035\036\n\026 \024\002\031\f\035\024\r\ )Tj 0 Tw (-)Tj 0.209 Tw T* (\035\036\027\026 \021\036\n, \004\021\024 \023\024\022\026\026\021\036\035\ \034 \004\026\f\021\024\021\t \026\032\017\r\035\036\027\017\016 \f\r\017\ )Tj 0 Tw (-)Tj 0.496 Tw T* (\013\036\005 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\035\026\036\030\027\024\005 \022\024\026\020\031\035\016\006\017\017, \ \002\036 \022\026\022\024\020\024-\035\017\002\024 )Tj 0.18 Tw T* (\026\022\030\t\021\017\016 \r\027\031\021\030\036\027\027\036\020\024 \f\ \r\017\013\036\r\024\020\024 \024\021\r\036\030\f\021\017\016, \r\026\030\ \034\017)Tj 0 Tw (-)Tj 0.147 Tw T* (\030\031\036\021 \r)Tj /Span<>> BDC ( )Tj EMC (\001\017\030\024\022\024\n \007\017\026\023\026\024\027\036)Tj /Span<>> BDC ( )Tj EMC (\227 \024\021 20 \007\024)Tj /Span<>> BDC ( )Tj EMC (89% [2,11]. )Tj 0.394 Tw T* (\212\024\023\024\035\027\017\021\036\035\034\027\024\036 \026\022\030\t\ \021\017\036 \r\027\031\021\030\036\027\027\036\020\024 \f\r\017\013\036\ \r\024\020\024 )Tj 0.019 Tw T* (\024\021\r\036\030\f\021\017\016, \002\036\031\f\035\024\r\027\024, \n\024\ \032\036\021 \023\024\r\t\f\017\021\034 \001\026\027\f\t \027\026)Tj /Span<>> BDC ( )Tj EMC (\026)Tj 0 Tw (-)Tj 0.412 Tw T* [(\032\017\r\035\036\027\017\036 )0.6(\f\r\017\013\026. )0.5(\215\030\017)]TJ /Span<>> BDC ( )Tj EMC 10.507 0 Td [(\026\027\026\035\017\036 )0.6(\023\031\002\035\017\022\026\006\017\005 )0.5(\031\f\021\026)]TJ 0 Tw (-)Tj 0.229 Tw -10.507 -1.218 Td (\027\024\r\035\036\027\024 \027\036\f\022\024\035\034\022\024 \027\026\017\ \002\024\035\036\036 \004\026\f\021\024 \r\f\021\030\036\004\026\033\013\ \017\b\f\016 )Tj 0.082 Tw T* (\r\026\030\017\026\027\021\024\r \024\002\030\026\002\024\021\022\017 \r\ \027\031\021\030\036\027\027\036\020\024 \f\r\017\013\036\r\024\020\024 \ \024\021\r\036\030)Tj 0 Tw (-)Tj 0.174 Tw T* (\f\021\017\016 \023\024\f\035\036 \r\t\023\024\035\027\036\027\017\016 \220\ \021\026\023\026 \035\026\036\030\027\024\005 \022\024\026\020\031\035\016\ \006\017\017 )Tj 0.224 Tw T* (\f\r\017\013\036\r\024\020\024 \b\024\007\026. \212\026\027\027\t\005 \220\ \021\026\023, \023\024)Tj /Span<>> BDC ( )Tj EMC (\027\026\001\036\n\031 \n\027\036\027\017\033, )Tj 0.059 Tw T* (\016\r\035\016\036\021\f\016 \022\035\033\004\036\r\t\n \n\024\n\036\027\ \021\024\n \035\033\002\024\020\024 \b\017\030\031\030\020\017\004\036\f\ \022\024)Tj 0 Tw (-)Tj 0.133 Tw T* (\020\024 \r\n\036\001\026\021\036\035\034\f\021\r\026 \023\024)Tj /Span<>> BDC ( )Tj EMC (\023\024\r\024\007\031 \f\r\017\013\036\005 \023\030\016\n\024\005 \022\017\ \001\022\017, )Tj -0.025 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\024\f\024\002\036\027\027\024\f\021\017 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\f\035\024\032\027\t\b \017\b \r\026\030\017\026\027\021\026\b. \213\f\035\ \017 \024\002\024\002)Tj 0 Tw (-)Tj 0.016 Tw T* (\013\017\021\034 \035\017\021\036\030\026\021\031\030\027\t\036 \007\026\ \027\027\t\036, \021\024 \022\030\024\n\036 \r\026\030\017\026\027\021\026\ , \022\024\020\007\026 )Tj 0.013 Tw T* (\r\027\031\021\030\036\027\027\036\036 \024\021\r\036\030\f\021\017\036 \ \027\017\022\026\022 \027\036 \024\002\030\026\002\026\021\t\r\026\036\021\ \f\016, \022\030\024)Tj 0 Tw (-)Tj -0.04 Tw T* (\n\036 \035\026\036\030\027\024\005 \022\024\026\020\031\035\016\006\017\ \017, \f\031\013\036\f\021\r\031\036\021 3 \f\023\024\f\024\002\026 \026\ \r\036\030)Tj 0 Tw (-)Tj 0.039 Tw T* (\001\036\027\017\016 \r\n\036\001\026\021\036\035\034\f\021\r\026. \200)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\r\031\033 \024\004\036\030\036\007\034, \220\021\024 \031\001\ \017\r\026)Tj 0 Tw (-)Tj 0.256 Tw T* (\027\017\036 \r\027\031\021\030\036\027\027\036\020\024 \f\r\017\013\036\ \r\024\020\024 \024\021\r\036\030\f\021\017\016 \024\021\007\036\035\034\ \027\t\n\017 )Tj 0.14 Tw T* (\031\035\024\r\t\n\017 \001\r\026\n\017 \017\035\017 \023\031\021\036\n\ \027\026\035\024\032\036\027\017\016 Z-\024\002\030\026\027\024\020\024\ )Tj 0.133 Tw T* (\001\r\026. \200\021\024\030\t\n \023\024)Tj /Span<>> BDC ( )Tj EMC (\004\026\f\021\024\021\036 \016\r\035\016\036\021\f\016 \r\026\030\017\026\ \027\021 \026\022\030\t\021\017\016 )Tj 0.327 Tw T* [(\r\027\031\021\030\036\027\027\036\020\024 )0.6(\f\r\017\013\036\r\024\020\024 )0.5(\024\021\r\036\030\f\021\017\016 )0.6(\f)]TJ /Span<>> BDC ( )Tj EMC 16.36 0 Td [(\023\024\n\024\013\034\033 )0.6(\035\024)]TJ 0 Tw (-)Tj 0.185 Tw -16.36 -1.218 Td (\f\022\031\021\026 \(\f\035\017\017\f\021\024-\023\024\007\f\035\017\017\ \f\021\t\005, \f\035\017\017\f\021\024-\n\t\001\036\004\027\t\005, )Tj 0.244 Tw T* (\022\024\032\027\024-\026\027\026\035\034\027\t\005\). \230\026\022\032\036\ \f\021\026\035\017 \023\024\016\r\035\016\021\034\f\016 \030\026\002\024\ \021\t, )Tj 0.217 Tw T* (\020\007\036 \017\f\023\024\035\034\024\r\026\035\026\f\034 \022\024\n\002\ \017\027\026\006\017\016 \035\026\036\030\027\024\005 \022\024\026\020\031\ \035\016)Tj 0 Tw (-)Tj 0.191 Tw T* (\006\017\017 \f\r\017\013\036\r\024\020\024 \b\024\007\026 \f)Tj /Span<>> BDC ( )Tj EMC (\n\036\021\024\007\017\022\024\005 \023\036\030\036\r\016\022\017 \f\r\017\ \013\026 )Tj 0.21 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\n\036\032\f\235\017\027\022\021\036\030\027\024\n \023\030\024\f\021\030\ \026\027\f\021\r\036 \(LIFT\). \203\026\f\022\024\035\034\022\024 )Tj -0.018 Tw T* (\f\017\035\034\027\024 \027\026)Tj /Span<>> BDC ( )Tj EMC (\004\026\f\021\024\021\031 \026\032\017\r\035\036\027\017\016 \f\r\017\013\ \026 \n\024\032\036\021 \023\024\r\035\017\016\021\034 )Tj 0.193 Tw T* (\f\023\024\f\024\002 \026\022\030\t\021\017\016 \r\027\031\021\030\036\027\ \027\036\020\024 \f\r\017\013\036\r\024\020\024 \024\021\r\036\030\f\021\ \017\016 )Tj 0.28 Tw T* (\n\024\032\027\024 \031\002\036\007\017\021\034\f\016 \f)Tj /Span<>> BDC ( )Tj EMC (\023\024\n\024\013\034\033 \030\016\007\026 \023\030\017\n\036\030\024\r\ . \230\026\022, )Tj -0.003 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC 0.703 0 Td [(\030\026\002\024\021\036 )0.5(\204\026\021\017\027\016\027\026)]TJ /Span<>> BDC ( )Tj EMC 7.262 0 Td [(\202.\200. )0.5(\(2021\) )0.5(\002\t\035\024 )0.5(\031\f\021\026\027\024\r\035\036\027\024, )0.6(\004\021\024 )]TJ 0.098 Tw -7.965 -1.218 Td (\f\030\036\007\017 31)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\026, \031)Tj /Span<>> BDC ( )Tj EMC (\022\024\021\024\030\t\b \r\027\031\021\030\036\027\027\036\036 \024\021\ \r\036\030\f\021\017\036 )Tj 0.207 Tw 23.244 64.543 Td [(\031\001\017\r\026\035\024\f\034 \024\021\007\036\035\034\027\t\n\017 )0.5(\001\r\026\n\017, \004\026\f\021\024\021\026 \026\032\017\r\035\036\027\ \017\016 )]TJ 0.12 Tw T* (\f\024\f\021\026\r\017\035\026 54,8%, \026 \031)Tj /Span<>> BDC ( )Tj EMC (14)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r, \022\024\021\024\030\t\n \r\t\023\024\ \035)Tj 0 Tw (-)Tj 0.005 Tw T* (\027\036\027\024 \026\022\030\t\021\017\036 \024\021\r\036\030\f\021\017\ \016 \f\035\017\017\f\021\024-\n\t\001\036\004\027\t\n \035\024\f\022\031\ )Tj 0 Tw (-)Tj 0.024 Tw T* (\021\024\n, \026\032\017\r\035\036\027\017\016 \f\r\017\013\026 \031\007\ \026\035\024\f\034 \007\024\f\021\017\004\034 \r)Tj /Span<>> BDC ( )Tj EMC (65,3% \f\035\031)Tj 0 Tw (-)Tj 0.053 Tw T* (\004\026\036\r [10,13]. \200)Tj /Span<>> BDC ( )Tj EMC (\f\021\026\021\034\036 \200\026\f\017\035\034\036\r\026)Tj /Span<>> BDC ( )Tj EMC (\221.\200. \f)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. \(2021\) )Tj -0.057 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\017\f\f\035\036\007\024\r\026\027\017\017 \206\024\030)Tj /Span<>> BDC ( )Tj EMC (\222.\202. \(2022\) \023\030\024\007\036\n\024\027\f\021\030\017\030\024\ \r\026\027\t )Tj -0.011 Tw 0 -1.218 TD [(\007\024\r\024\035\034\027\024 \b\024\030\024\001\017\036 \030\036\031\035\ \034\021\026\021\t )0.5(\023\030\017\n\036\027\036\027\017\016 \n\036\021\024\007\017\022\017, )]TJ 0.238 Tw 0 -1.218 TD (\f\024\004\036\021\026\033\013\036\005 \035\026\036\030\027\031\033 \022\ \024\026\020\031\035\016\006\017\033 \f\r\017\013\036\r\024\020\024 \b\024\ \007\026 )Tj 0.227 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\036\020\024 \023\036\030\036\r\016\022\024\005 \r)Tj /Span<>> BDC ( )Tj EMC (\n\036\032\f\235\017\027\022\021\036\030\027\024\n \023\030\024\f\021\030\ \026\027\f\021\r\036 )Tj 0.248 Tw T* ([12,16]. \215\030\017)Tj /Span<>> BDC ( )Tj EMC (\007\026\027\027\024\n \f\024\004\036\021\026\027\017\017 \026\032\017\r\ \035\036\027\017\036 \f\r\017\013\026 )Tj 0.054 Tw T* (\023\030\024\017\024\001\035\024 \031)Tj /Span<>> BDC ( )Tj EMC (88,2% \023\026\006\017\036\027\021\024\r, \026)Tj /Span<>> BDC ( )Tj EMC (\023\030\017 \017\024\035\017\030\024\r\026\027\027\024\005 )Tj 0 Tw T* (\n\036\021\024\007\017\022\036 LIFT)Tj /Span<>> BDC ( )Tj EMC (\227 \r)Tj /Span<>> BDC ( )Tj EMC (74,1% \f\035\031\004\026\036\r [12].)Tj 0.347 Tw 0 -1.218 TD (\230\026\022\017\n \024\002\030\026\024\n, \027\026)Tj /Span<>> BDC ( )Tj EMC (\f\036\020\024\007\027\016\001\027\017\005 \007\036\027\034 \024\021\f\031\ \021\f\021\r\031\036\021 )Tj 0.068 Tw 0 -1.218 TD [(\036\007\017\027\026\016 \022\024\027\006\036\023\006\017\016 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC [(\024\021\027\024\001\036\027\017\017 )0.5(\007\036\005\f\021\r\017\005 \f)]TJ /Span<>> BDC ( )Tj EMC (\r\027\031\021\030\036\027)Tj 0 Tw (-)Tj 0.081 Tw 0 -1.218 TD [(\027\017\n )0.5(\f\r\017\013\036\r\t\n )0.6(\024\021\r\036\030\f\021\017\036\n)]TJ /Span<>> BDC ( )Tj EMC 11.47 0 Td [(\227 )0.5(\031\001\017\r\026\021\034 )0.5(/ )0.5(\027\036 )0.6(\031\001\017\r\026\021\034, )]TJ 0.033 Tw -11.47 -1.218 Td (\031\001\017\r\026\021\034 / \r\t\023\024\035\027\017\021\034 \026\022\030\ \t\021\017\036 \024\021\r\036\030\f\021\017\016 \f)Tj /Span<>> BDC ( )Tj EMC (\023\024\n\024\013\034\033 )Tj -0.022 Tw T* (\035\024\f\022\031\021\026 \017\035\017 \017\f\023\024\035\034\024\r\026\ \021\034 \035\026\036\030\027\031\033 \022\024\026\020\031\035\016\006\017\ \033 \r)Tj /Span<>> BDC ( )Tj EMC (\f\024)Tj 0 Tw (-)Tj 0.346 Tw T* (\004\036\021\026\027\017\017 \f)Tj /Span<>> BDC ( )Tj EMC (\n\036\021\024\007\017\022\024\005 LIFT. \230\030\036\002\031\036\021\f\016\ \023\030\024\r\036\007\036\027\017\036 )Tj 0.107 Tw T* [(\f\030\026\r\027\017\021\036\035\034\027\t\b, )0.6(\032\036\035\026\021\036\035\034\027\024 )0.5(\030\026\027\007\024\n\017\017\030\024\r\026\027\027\t\b )0.6(\017\f)]TJ 0 Tw (-)Tj 0.128 Tw T* [(\f\035\036\007\024\r\026\027\017\005, )0.5(\022\024\021\024\030\t\036 \n\024\020\035\017 \002\t \023\030\024\007\036\ \n\024\027\f\021\030\017\030\024\r\026\021\034 )]TJ 0.252 Tw T* (\220\235\235\036\022\021\017\r\027\024\f\021\034 \021\024\020\024 \017\035\ \017 \017\027\024\020\024 \f\023\024\f\024\002\026 \024\002\030\026\002\024\ \021\022\017 )Tj 0.221 Tw T* (\r\027\031\021\030\036\027\027\036\020\024 \f\r\017\013\036\r\024\020\024\ \024\021\r\036\030\f\021\017\016 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\017\f\023\024\035\034\024\r\026)Tj 0 Tw (-)Tj 0.119 Tw T* [(\027\017\017 )0.5(\021\036\b\027\024\035\024\020\017\017 )0.5(\035\026\036\030\027\024\005 )0.5(\022\024\026\020\031\035\016\006\017\017 )0.6(\f\r\017\013\026. )0.5(\037\036\035\034\033 )]TJ 0.452 Tw T* (\007\026\027\027\024\005 \023\031\002\035\017\022\026\006\017\017 \016\r\ \035\016\036\021\f\016 \026\027\026\035\017 \030\036\031\035\034\021\026\ \021\024\r )Tj 0.153 Tw T* (\035\036\004\036\027\017\016 \023\026\006\017\036\027\021\024\r, \022\024\ \021\024\030\t\n \023\030\017\n\036\027\036\027\026 \021\036\b\027\024\035\ \024\020\017\016 )Tj 0.28 Tw T* (\035\026\036\030\027\024\005 \022\024\026\020\031\035\016\006\017\017 \f\ \r\017\013\026 \r)Tj /Span<>> BDC ( )Tj EMC (\205\206\207\211 \253\203\204\222\037 \022\024\035\024)Tj 0 Tw (-)Tj 0.105 Tw T* (\023\030\024\022\021\024\035\024\020\017\017 \017\n\036\027\017 \202.\203\ . \217\t\032\017\b\273 \204\017\027\007\030\026\r\026 \217\024\f\f\017\017\ , )Tj 0.141 Tw T* (\023\030\017)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\n \027\026\017\002\024\035\034\001\017\005 \017\027\021\036\ \030\036\f \023\030\036\007\f\021\026\r\035\016\036\021 \024\006\036\027\ \022\026 )Tj 0.217 Tw T* (\004\026\f\021\024\021\t \026\032\017\r\035\036\027\017\016 \r)Tj /Span<>> BDC ( )Tj EMC (\026\r\017\f\017\n\024\f\021\017 \024\021 \f\023\024\f\024\002\026 \026\ )Tj 0 Tw (-)Tj T* (\022\030\t\021\017\016 \r\027\031\021\030\036\027\027\036\020\024 \f\r\017\ \013\036\r\024\020\024 \024\021\r\036\030\f\021\017\016.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.01 Tc 0.018 Tw 14 0 0 14 275.0305 335.1338 Tm [(\f\026\017\031\034\022\024\232)5( \031)5(\016)-18.3(\240\034)-31(\024)35(\037\226\232)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0 Tc 0.236 Tw 10 0 0 10 274.9606 310.7778 Tm (\221 \f\036\027\021\016\002\030\016 2018)Tj /Span<>> BDC ( )Tj EMC (\020. \023\024)Tj /Span<>> BDC ( )Tj EMC (\n\026\030\021 2023)Tj /Span<>> BDC ( )Tj EMC (\020. \027\026)Tj /Span<>> BDC ( )Tj EMC (\002\026\036 \205\206\207\211 )Tj 0.864 Tw T* (\253\203\204\222\037)Tj /Span<>> BDC ( )Tj EMC (\022\024\035\024\023\030\024\022\021\024\035\024\020\017\017 \017\n\036\027\ \017 \202.\203.)Tj /Span<>> BDC ( )Tj EMC (\217\t\032\017\b\273 )Tj 0.096 Tw T* (\204\017\027\007\030\026\r\026 \217\024\f\f\017\017 121 \023\026\006\017\ \036\027\021\031 \f)Tj /Span<>> BDC ( )Tj EMC (\021\030\026\027\f- \017)Tj /Span<>> BDC ( )Tj EMC (\220\022\f\021\030\026\f)Tj 0 Tw (-)Tj 0.168 Tw T* (\235\017\027\022\021\036\030\027\t\n\017 \f\r\017\013\026\n\017 \023\030\ \016\n\024\005 \022\017\001\022\017 \002\t\035\017 \r\t\023\024\035)Tj 0 Tw (-)Tj 0.368 Tw T* (\027\036\027\t \024\023\036\030\026\021\017\r\027\t\036 \r\n\036\001\026\ \021\036\035\034\f\021\r\026 \f)Tj /Span<>> BDC ( )Tj EMC (\023\030\017\n\036\027\036\027\017\036\n )Tj 0.382 Tw T* (\035\026\036\030\027\024\005 \022\024\026\020\031\035\016\006\017\017 \f\ \r\017\013\036\r\024\020\024 \b\024\007\026. \200)Tj /Span<>> BDC ( )Tj EMC (\021\036\004\036\027\017\036 )Tj 0.207 Tw T* (\031\022\026\026\027\027\024\020\024 \023\036\030\017\024\007\026 \r\030\ \036\n\036\027\017 \024\023\036\030\026\006\017\017 \f)Tj /Span<>> BDC ( )Tj EMC (\023\030\017\n\036\027\036)Tj 0 Tw (-)Tj 0.22 Tw T* (\027\017\036\n \035\026\036\030\027\024\005 \022\024\026\020\031\035\016\ \006\017\017 \f\024\004\036\021\026\035\017\f\034 \f)Tj /Span<>> BDC ( )Tj EMC (3 \030\026\035\017\004)Tj 0 Tw (-)Tj 0.176 Tw T* (\027\t\n\017 \r\026\030\017\026\027\021\026\n\017 \026\022\030\t\021\017\ \016 \r\027\031\021\030\036\027\027\036\020\024 \f\r\017\013\036\r\024\020\ \024 )Tj 0.047 Tw T* (\024\021\r\036\030\f\021\017\016. \230\026\022, \r)Tj /Span<>> BDC ( )Tj EMC (\030\026\n\022\026\b \027\026\031\004\027\024\020\024 \017\f\f\035\036\007\ \024\r\026\027\017\016, \020\007\036 )Tj 0.016 Tw T* [(\r\t\023\024\035\027\016\035\026\f\034 )0.5(\f\030\026\r\027\017\021\036\035\034\027\026\016 \024\006\036\027\022\026\ \030\036\031\035\034\021\026\021\024\r )0.5(\022\024\026)]TJ 0 Tw (-)Tj 0.024 Tw T* [(\020\031\035\016\006\017\017 )0.5(\f\021\036\027\024\022 \f\r\017\013\036\r\024\020\024 )0.5(\b\024\007\026 \f)]TJ /Span<>> BDC ( )Tj EMC 14.101 0 Td [(\023\024\n\024\013\034\033 )0.5(\007\017\024\007\027\024\020\024 )]TJ 0.197 Tw -14.101 -1.218 Td (\035\026\036\030\026 \017)Tj /Span<>> BDC ( )Tj EMC (\n\024\027\024\023\024\035\016\030\027\024\005 \220\035\036\022\021\030\024\ \022\024\026\020\031\035\016\006\017\017 \(\017\f\f\035\036)Tj 0 Tw (-)Tj 0.06 Tw T* (\007\024\r\026\027\017\036)Tj /Span<>> BDC ( )Tj EMC 3.72 0 Td [(1\), )0.5(\r\027\031\021\030\036\027\027\036 )0.6(\f\r\017\013\036\r\024\036 )0.5(\024\021\r\036\030\f\021\017\036 )0.6(\026\022\030\t\r\026)]TJ 0 Tw (-)Tj -0.016 Tw -3.72 -1.218 Td (\035\024\f\034 \035\017\002\024 \024\021\007\036\035\034\027\t\n\017 \031\ \035\024\r\t\n\017 \001\r\026\n\017, \035\017\002\024 \f)Tj /Span<>> BDC ( )Tj EMC (\023\024\n\024)Tj 0 Tw (-)Tj -0.032 Tw T* (\013\034\033 \027\017\r\036\007\036\027\017\016 \f\035\017\017\f\021\024\ -\n\t\001\036\004\027\024\020\024 \035\024\f\022\031\021\026 \f\021\036\027\ \022\017 )Tj 0.11 Tw T* (\023\030\016\n\024\005 \022\017\001\022\017 [10,13]. \200)Tj /Span<>> BDC ( )Tj EMC (\030\026\n\022\026\b \007\017\026\005\027\026 2-\020\024 \f\030\026\r)Tj 0 Tw (-)Tj 0.104 Tw T* (\027\017\021\036\035\034\027\024\020\024 \017\f\f\035\036\007\024\r\026\027\ \017\016 \(\017\f\f\035\036\007\024\r\026\027\017\036 2\) \023\026\006\017\ \036\027)Tj 0 Tw (-)Tj 0.158 Tw T* (\021\t \030\026\027\007\024\n\017\017\030\024\r\026\035\017\f\034 \r)Tj /Span<>> BDC ( )Tj EMC (2)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\t. \200)Tj /Span<>> BDC ( )Tj EMC (\024\007\027\024\005 \020\030\031\023\023\036 )Tj -0.028 Tw T* (\r\t\023\024\035\027\016\035\026\f\034 \035\026\036\030\027\026\016 \022\ \024\026\020\031\035\016\006\017\016 \f\r\017\013\026 \f)Tj /Span<>> BDC ( )Tj EMC (\023\035\026\f\021\017\022\024\005 )Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 0 Tw 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\033\030\031\030\213\b)-20.9(\035\231\213\233\t \021\032)50(\b)42(\032\231\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj /T1_3 1 Tf 25 0 0 25 512.002 56.0378 Tm (61)Tj ET endstream endobj 1829 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1830 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1831 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1832 0 obj <>/ExtGState<>/Font<>/ProcSet[/PDF/Text]/Properties<>/Shading<>/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1833 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1947 0 obj <>stream q /GS0 gs /Fm0 Do Q 0 0 0 1 K 1 j 1 J [0 2.997]0 d /GS1 gs q 1 0 0 1 74.3631 427.5757 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 71.3661 427.5757 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q [0 2.997]0 d q 1 0 0 1 74.3631 390.3679 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 71.3661 390.3679 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q 0 j 0 J q 1 0 0 1 70.8661 336.2986 cm 0 0 m 453.543 0 l S Q BT 0 0 0 1 k /T1_0 1 Tf 5.83 0 0 5.83 70.8661 733.048 Tm (1)Tj 0.023 Tw 10 0 0 10 74.1775 729.718 Tm [(R)20(y)21(zhikh National Medical Resear)31(ch Center of Colopr)20.1(octology \(Saly)21(ama Adily)21(a\022)-23.3(st., 2, Moscow)22(, 1)125(23)58(423, Russia\))]TJ 0 Tw ( )Tj 5.83 0 0 5.83 70.8661 721.0481 Tm (2)Tj 0.023 Tw 10 0 0 10 74.1775 717.7181 Tm [(Russian Medical Academ)21.1(y of Continuous Pr)20(ofessional Education \(Barrikadnay)21.1(a\022)-23.3(st., 2/1-1)69(, Moscow)22(, 1)125(2)23(5)23(99)35(3, )]TJ 0 Tw -0.331 -1.2 Td (Russia\))Tj /T1_1 1 Tf -0.033 Tw 9 0 0 9 119.0551 687.2142 Tm [(AIM: to estimate the results of treatment for trans- and e)-14.9(xtrasphincter)-36.9(ic anal f)-43(istulas by laser coagulation depending )]TJ 0.023 Tw 0 -1.111 TD [(on the method of inter)-14(nal f)-43(istula closure.)]TJ 0.126 Tw T* [(P)45(A)45(TIENT)-9.9(S A)53(ND METHODS: the study included 121 patients under)-32(w)12(ent surg)12(er)-43(y with laser coagulation of the anal )]TJ 0.066 Tw T* [(f)-43(istulas in combination with 3 dif)-40(ferent w)13(ays of inter)-14(nal f)-43(istula closure ov)13(er a 5-year per)-37(iod. F)12(or)-39.9(ty)-13.9(-three patients )]TJ 0.026 Tw T* [(w)12(ere )0.5(included )0.5(in the )0.5(g)13.9(roup )0.5(of )0.5(laser )0.5(coagulation )0.5(of anal )0.5(f)-43(istulas )0.5(with )0.5(its lig)12(ation in )0.5(the intersphincter)-37(ic f)-43(istula tract )]TJ 0.012 Tw 0 -1.111 TD (\(LC)Tj /Span<>> BDC ( )Tj EMC (+)Tj /Span<>> BDC ( )Tj EMC (LIFT\), 47)Tj /Span<>> BDC ( )Tj EMC [(\227 in the g)14(roup of laser coagulation of the f)-43(istula with the inter)-14(nal opening closure with a adv)16(ance)]TJ 0 Tw (-)Tj 0.056 Tw 0 -1.111 TD [(ment )0.5(f)-21.9(lap )0.5(\(LC)]TJ /Span<>> BDC ( )Tj EMC 5.705 0 Td (+)Tj /Span<>> BDC ( )Tj EMC 0.788 0 Td [(AF\), )0.5(31)]TJ /Span<>> BDC ( )Tj EMC 3.207 0 Td [(\227 )0.5(in )0.5(the )0.5(g)14(roup )0.5(of )0.5(laser )0.6(coagulation )0.6(of )0.5(the )0.5(anal )0.5(f)-43(istulas )0.5(with )0.5(sutur)-37(ing )0.5(of )0.5(the )0.5(inter)-14(nal )0.5(f)-43(is)]TJ 0 Tw (-)Tj 0.033 Tw -9.701 -1.111 Td [(tulous opening by separate sutures \(L)30(T)]TJ /Span<>> BDC ( )Tj EMC (+)Tj /Span<>> BDC ( )Tj EMC [(SIF)11(O\). P)18(atients w)12(ere ag)12(ed 42 \(20-70\) years, 82 males. The follow-up w)13(as )]TJ 0.008 Tw T* [(19 \(3-52\) months. Preoperativ)13.1(ely)42(, 1 and 2 months af)-46(ter surg)12(er)-43(y)42(, the patients under)-32(w)12(ent ultrasound to ev)16(aluate the )]TJ 0.05 Tw T* [(p)46(rocess of f)-43(istula healing and early detection of recur)-16(rences. T)53(o assess the functional results, sphincterometr)-43(y w)13(as )]TJ 0.023 Tw T* [(per)-34(for)-13.9(med before the surg)12(er)-43(y and 3 months af)-46(ter surg)12(er)-42.9(y)32(.)]TJ 0.094 Tw T* [(RESUL)30(T)-10(S: )0.6(in )0.5(the )0.6(L)30(T)]TJ /Span<>> BDC ( )Tj EMC 7.811 0 Td (+)Tj /Span<>> BDC ( )Tj EMC 0.826 0 Td [(LIFT )0.6(g)13.9(roup, )0.6(f)-43(istula )0.6(healing )0.6(rev)13(ealed )0.5(in )0.6(33/43 )0.5(\(76.7%\) )0.6(patients, )0.6(in )0.5(the )0.5(L)30(T)]TJ /Span<>> BDC ( )Tj EMC 29.607 0 Td (+)Tj /Span<>> BDC ( )Tj EMC 0.826 0 Td [(AF )0.5(g)14(roup)]TJ /Span<>> BDC ( )Tj EMC 3.883 0 Td [(\227 )0.5(in )]TJ 0.099 Tw -42.954 -1.111 Td [(33/47 \(70.2%\) patients, in the L)30(T)]TJ /Span<>> BDC ( )Tj EMC (+)Tj /Span<>> BDC ( )Tj EMC [(SIF)11(O g)14(roup)]TJ /Span<>> BDC ( )Tj EMC (\227 in 17/31 \(54.8%\) patients \(p)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC [(0.129\). The only identif)-43(ied )]TJ 0.088 Tw T* [(factor that show)12(ed a signif)-42.9(icant ef)-39.9(fect on positiv)13(e result in the L)30(T)]TJ /Span<>> BDC ( )Tj EMC (+)Tj /Span<>> BDC ( )Tj EMC [(LIFT g)14(roup w)13(as the diameter of the inter)-13.9(nal )]TJ 0.005 Tw 0 -1.111 TD [(f)-43(istulous opening. Thus, if the diameter of the f)-43(istulous opening w)13(as more than 3 mm, positiv)13(e result occur)-16(red in 24 )]TJ 0.037 Tw 0 -1.111 TD [(\(54,5%\), and if the diameter of the opening w)13(as)]TJ /Span<>> BDC ( )Tj EMC (\244)Tj /Span<>> BDC ( )Tj EMC [(3,0 mm, the anal f)-43(istulas healed in 58 \(75,3%\) out of 77 cases )]TJ 0.033 Tw T* (\(p)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC [(0,025\). The hospital stay w)13(as 3.5 d)26(ays. Com)16(plications dur)-36.9(ing surg)12(er)-43(y and the immediate postoperativ)13(e per)-37(iod )]TJ 0.023 Tw T* [(occur)-15.9(red only in 3 \(2.5%\) cases.)]TJ 0.013 Tw T* [(C)21(ON)22(CLUSION: laser coagulation has p)46(rov)13(en to be a sphincter)23.1(-saving surg)12(er)-43(y alter)-14(nativ)12.9(e to con)11(v)13(entional one for anal )]TJ -0.018 Tw T* [(f)-43(istula in a selected g)14(roup of patients, with a high lev)13(el of safety reg)12(ardless of the method of inter)-14(nal f)-42.9(istula closure. )]TJ 0.038 Tw T* [(The )0.6(best )0.5(healing )0.6(rates )0.6(w)12(ere )0.6(rev)13(ealed )0.6(when )0.5(laser )0.6(coagulation )0.7(w)13(as )0.5(combined )0.6(with )0.5(lig)11.9(ation )0.5(of )0.5(the )0.6(anal )0.5(f)-42.9(istulas )0.6(in )0.5(the )]TJ 0.033 Tw T* [(intersphincter)-36.9(ic tract \(76.7%\), but the search for the most reliable method of isola\ ting the anal f)-43(istulas should be )]TJ 0 Tw T* (continued.)Tj /T1_2 1 Tf 0.01 Tc -0.01 Tw 8 0 0 8 70.9061 451.9449 Tm [(KEYW)22(ORDS:)]TJ /T1_1 1 Tf 0 Tc 0.023 Tw 4.948 0 Td [( anal f)-43(istula, laser coagulation, LIFT)74(, adv)16.1(ancement f)-22(lap,FiLaC)]TJ /T1_2 1 Tf 0.01 Tc 0.018 Tw -4.948 -1.909 Td [(CONFLICT)5( OF)5( INTERESTS:)]TJ /T1_1 1 Tf 0 Tc 0.023 Tw 10.434 0 Td ( The authors declare no conflicts of interest)Tj /T1_2 1 Tf 0.037 Tc 0.149 Tw -10.434 -2.617 Td [(F)3.2(O)-4.6(R)8.7( )0.5(C)-17.5(I)-15.5(T)45.4(A)37.5(T)-24.5(I)-1.3(ON:)]TJ /T1_3 1 Tf 0.023 Tc 0.158 Tw 6.593 0 Td [( )0.5(K)-11.2(o)-15.8(s)-29.3(t)-36.8(a)-10.2(r)-19.1(e)-15.8(v)]TJ /Span<>> BDC ( )Tj EMC 4.597 0 Td [(I)-10.3(.)40.6(V)39.7(.)-23.5(, )0.5(Z)-34(a)-11.2(k)-16.8(h)-8.3(a)-10.2(r)-60.6(y)-24.2(a)-7.6(n)]TJ /Span<>> BDC ( )Tj EMC 7.005 0 Td [(A)-23(.)40.6(V)39.7(.)-23.5(, )0.5(K)-18.2(i)-7.4(s)-22.9(e)-18(l)-23.7(e)-15.8(v)]TJ /Span<>> BDC ( )Tj EMC 5.83 0 Td [(D)16.4(.)12.4(O)11.4(.)-23.5(, )0.5(B)-10.4(l)-37.8(a)-10.8(g)-10.2(o)-20.4(d)-9.3(a)-10.2(r)-35.9(n)-14.9(y)]TJ /Span<>> BDC ( )Tj EMC 7.715 0 Td [(L)-29.5(.)-23.9(A)-23(.)-23.5(, )0.5(M)-5.7(u)-10.4(d)-10.4(r)-15.8(o)-10.3(v)]TJ /Span<>> BDC ( )Tj EMC 5.952 0 Td [(A)-23(.)-23.9(A)-23(.)-23.5(, )0.5(T)-17.3(i)-15.8(t)-21.9(o)-10.3(v )0.5(A)-23(.)51.6(Y)12.6(u)-9(. . F)-29(i)-14.5(v)-18.7(e)-30.9(-)-17.7(y)-20.5(e)-13(a)-10.2(r )0.5(e)-33.1(x)-24.7(p)-24.7(e)-12.1(r)-56.4(i)-11(e)-11.5(n)-10(c)-9.7(e )0.5(o)-12.1(f)23( )]TJ 0.15 Tw -37.697 -1.2 Td [(l)-37.8(a)-26.6(s)-22.9(e)-12.1(r c)-6.5(o)-18.2(a)-10.8(g)-9.5(u)-8.4(l)-37.8(a)-18.2(t)-46.2(i)-6.8(o)-9.2(n i)-3.2(n t)-26.1(h)-15.1(e t)-30.7(r)-19.1(e)-13(a)-18.2(t)-26.1(m)-16.6(e)-11.5(n)-17.3(t o)-12.1(f t)-30.8(r)-30.8(a)-7.6(n)-11.2(s)-12.6(- a)-7.6(n)-14.5(d s)-8.8(u)-6.2(p)-13.7(r)-30.8(a)-26.6(s)-9.3(p)-15.9(h)-14(i)-3.2(n)-10(c)-41.5(t)-24.7(e)-12.1(r)-56.4(i)-5(c a)-7.6(n)-7.8(a)-11.4(l f)-63(i)-7.4(s)-29.3(t)-22.3(u)-8.4(l)-37.8(a)-26.6(s)-15.5(. )]TJ /T1_1 1 Tf 0.033 Tc -0.033 Tw [(K)13.9(ol)3.7(op)2.4(r)3.1(o)3.4(k)-19.2(t)2.3(ol)3.6(o)-3.3(g)-13.2(i)6.7(a)5.9(.)]TJ /T1_3 1 Tf 0.013 Tc 0.16 Tw 43.366 0 Td [( 2)-18.9(0)-13.8(2)-1.2(4;2)-20.3(3)-4(\()27.7(1)34.3(\))4.5(:)-5.8(5)-5(9)-32.5(\226)34.3(7)1.2(0)-3.5(.)-10.3( \()-10.9(i)-13.2(n)-10.3( R)-16.5(u)-31.9(s)-32.3(s)-25.5(.)33.2(\).)13( )]TJ 0.012 Tc -0.012 Tw -43.366 -1.2 Td [(h)-28.2(t)-60.4(t)-40.4(p)-29.7(s)-19(:)-9.1(/)73.7(/)25.4(d)-22.1(o)-23.5(i)-11.2(.)-8.3(o)-22.8(r)-27.7(g)-33.8(/1)3(0)-4.5(.)-16.6(3)-3.1(3)-26.9(8)-9.7(7)-6.4(8)-11(/)-3.1(2)-19.9(0)-1.7(7)-12.9(3)-24.3(-)30.2(75)-10.6(5)-19.9(6)-37.8(-)-1.2(2)-20(0)-14.8(2)-2.2(4)-39.5(-)-1.3(2)-21.3(3)-24.3(-)44.1(1)15.9(-)-18.9(5)-5.9(9)-34.6(-)30.2(70)]TJ /T1_2 1 Tf 0.01 Tc 0.111 Tw 0.005 -2.617 Td [(\026\020\021\033\030)5( )0.6(\020\036\017)5( )0.5(\013\033\021\033\013\023\030\037\023:)]TJ /T1_1 1 Tf 0 Tc 0.116 Tw 10.762 0 Td [( )0.5(\221\026\004\026\032\002\021 )0.6(\201.\216., )0.6(\225\210\213\214 )0.6(\253\217\240\215\037 )0.6(\013\n\023\n\033\032\n\013\024\n\023\n\202\025\025 )0.6(\025\003\031\021\025 )0.6(\201.\217.)]TJ /Span<>> BDC ( )Tj EMC 24.505 0 Td [(\212\020\204\025\004\273 )0.6(\240\025\021\016\030\032\026\027\026 )0.6(\212\n\t\t\025\025, )0.6(\205\023.)]TJ /Span<>> BDC ( )Tj EMC 13.275 0 Td [(\207\026\023\002\003\026 )0.6(\201\030\025\023\002, )0.6(\030.)]TJ /Span<>> BDC ( )Tj EMC 7.442 0 Td (2, )Tj 0.023 Tw -55.989 -1.2 Td (\240\n\t\013\027\026, 123423, \212\n\t\t\025\002; e-mail: surgeon2108@ic\ loud.com)Tj /T1_2 1 Tf 0.01 Tc 0.055 Tw 0.005 -1.2 Td [(ADDRESS)5( F)13(OR)5( C)19(ORRESPONDEN)23(CE:)]TJ /T1_1 1 Tf 0 Tc 0.06 Tw 14.125 0 Td [( Zakhar)-36.9(ian A.V)61(., Ryzhikh N)18(ational Medical R)21(esearch Center of Colop)46(roctology)42.1(, Salyama Adilya st., 2, Moscow)52.1(, )]TJ 0.023 Tw -14.13 -1.2 Td [(123423, R)22(ussia; e-mail: surg)12(eon2108@icloud.com)]TJ 0 Tw 0 -2.792 TD (\200\026\024\026 \033\n\t\024\205\033\023\031\021\025\002)Tj /Span<>> BDC ( )Tj EMC (\227 05.12.2023)Tj /Span<>> BDC ( )Tj EMC 19.488 0 Td (\n\t\023\031 \030\n\032\026\005\n\024\013\025)Tj /Span<>> BDC ( )Tj EMC (\227 22.12.2023)Tj /Span<>> BDC ( )Tj EMC 18.78 0 Td (\032\025\021\002\024\n \013)Tj /Span<>> BDC ( )Tj EMC (\033\205\005\023\025\013\026\203\025\025)Tj /Span<>> BDC ( )Tj EMC (\227 12.02.2024)Tj ( )Tj -38.268 -1.375 Td (Received)Tj /Span<>> BDC ( )Tj EMC (\227 05.12.2023)Tj /Span<>> BDC ( )Tj EMC 19.488 0 Td (Revised)Tj /Span<>> BDC ( )Tj EMC (\227 22.12.2023)Tj /Span<>> BDC ( )Tj EMC 18.78 0 Td (Accepted for publication)Tj /Span<>> BDC ( )Tj EMC (\227 12.02.2024)Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 70.936 274.2439 Tm (\023\023\034\226\034\022\031\034)Tj 0 0 0 1 k /GS1 gs /T1_3 1 Tf 0 Tc 0.015 Tw 10 0 0 10 70.8661 249.8879 Tm (\221\030\036\007\017 \f\024\r\030\036\n\036\027\027\t\b \n\036\021\024\007\ \024\r \035\036\004\036\027\017\016 \f\r\017\013\036\005 \023\030\016\n\024\ \005 )Tj 0.262 Tw 0 -1.218 TD (\022\017\001\022\017 \027\026)Tj /Span<>> BDC ( )Tj EMC (\f\036\020\024\007\027\016\001\027\017\005 \007\036\027\034 \001\017\030\ \024\022\024\036 \023\030\017\n\036\027\036\027\017\036 )Tj 0.005 Tw T* [(\023\024\035\031\004\017\035 )0.5(\f\023\024\f\024\002 \035\026\036\030\027\024\005 )0.5(\022\024\026\020\031\035\016\006\017\017 )0.5([1\22615]. \200)]TJ /Span<>> BDC ( )Tj EMC 19.921 0 Td (\026\030\031)Tj 0 Tw (-)Tj 0.012 Tw -19.921 -1.218 Td [(\002\036\032\027\024\005 \035\017\021\036\030\026\021\031\030\036 )0.5(\n\036\021\024\007\017\022\026 \023\024\035\031\004\017\035\026 \026\002\ \002\030\036\r\017\026\021\031\030\031 )]TJ -0.116 Tw T* [(F)-19(iL)-32(aC\250 \(F)-19(istul)-16(a L)-32(aser Cl)30(oser\). \221\023\024\f\024\002 \024\021\027\024\f\017\021\f\016 \022)]TJ /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 )Tj -0.047 Tw T* (\f\235\017\027\022\021\036\030\024\f\002\036\030\036\020\026\033\013\017\ \b \r\n\036\001\026\021\036\035\034\f\021\r \017)Tj /Span<>> BDC ( )Tj EMC (\f\r\016\026\027 \f)Tj /Span<>> BDC ( )Tj EMC (\022\024\026)Tj 0 Tw (-)Tj -0.054 Tw T* (\020\031\035\016\006\017\036\005 \f\021\036\027\024\022 \f\r\017\013\036\ \r\024\020\024 \b\024\007\026 \f)Tj /Span<>> BDC ( )Tj EMC (\023\024\n\024\013\034\033 \007\017\024\007\027\024\020\024 )Tj -0.03 Tw T* (\035\026\036\030\026, \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\n \r)Tj /Span<>> BDC ( )Tj EMC (\030\026\n\022\026\b \r\n\036\001\026\021\036\035\034\f\021\r\026 \027\036\ \023\030\024\017\r\024)Tj 0 Tw (-)Tj -0.012 Tw T* (\007\017\021\f\016 \022\026\022\024\020\024-\035\017\002\024 \023\036\030\ \036\f\036\004\036\027\017\016 \f\021\030\031\022\021\031\030 \026\023\017\ \030\026\021\036\035\034)Tj 0 Tw (-)Tj -0.002 Tw T* (\027\024\020\024 \026\023\023\026\030\026\021\026 \023\030\016\n\024\005\ \022\017\001\022\017 \(\003\202\215\025\). \203\036\f\n\024\021\030\016\ \027\026)Tj /Span<>> BDC ( )Tj EMC (\021\024, )Tj 0.041 Tw T* (\004\021\024 \f)Tj /Span<>> BDC ( )Tj EMC 2.334 0 Td [(\n\024\n\036\027\021\026 \023\024\016\r\035\036\027\017\016 )0.5(\007\026\027\027\024\005 \021\036\b\027\024\035\024\020\017\017 )0.5(\023\030\024\001\035\024 )]TJ 0.089 Tw -2.334 -1.218 Td (\031\032\036 \002\024\035\036\036 10 \035\036\021, \036\007\017\027\024\005\ \022\024\027\006\036\023\006\017\017 \024)Tj /Span<>> BDC ( )Tj EMC (\027\036\024\002\b\024\007\017\n\024)Tj 0 Tw (-)Tj 0.19 Tw T* (\f\021\017 \f\023\036\006\017\026\035\034\027\024\020\024 \026\022\030\t\ \021\017\016 \r\027\031\021\030\036\027\027\036\020\024 \f\r\017\013\036\ \r\024\020\024 )Tj 0.011 Tw T* (\024\021\r\036\030\f\021\017\016, \f\023\024\f\024\002\036 \036\020\024 \ \026\022\030\t\021\017\016 \027\036 \f\031\013\036\f\021\r\031\036\021 \ [1,4]. )Tj 0.075 Tw T* (\230\026\022\032\036 \r)Tj /Span<>> BDC ( )Tj EMC (\030\026\n\022\026\b \023\030\024\r\036\007\036\027\027\t\b \017\f\f\035\ \036\007\024\r\026\027\017\005 \027\036 \002\t\035\024 )Tj 0.307 Tw 23.244 20.703 Td (\031\f\021\026\027\024\r\035\036\027\024 \235\026\022\021\024\030\024\r,\ \022\024\021\024\030\t\036 \n\024\020\035\017 \002\t \024\022\026\026\021\ \034 )Tj 0.329 Tw T* (\r\035\017\016\027\017\036 \027\026)Tj /Span<>> BDC ( )Tj EMC (\030\017\f\022 \030\026\r\017\021\017\016 \030\036\006\017\007\017\r\026\ \026\002\024\035\036\r\026\027\017\016 )Tj 0 Tw T* ([1,4]. \215\024)Tj /Span<>> BDC ( )Tj EMC (\007\026\027\027\t\n \024\021\007\036\035\034\027\t\b \026\r\021\024\030\ \024\r, \r\036\030\024\016\021\027\024\f\021\034 \023\024)Tj (-)Tj -0.038 Tw T* (\035\031\004\036\027\017\016 \b\024\030\024\001\017\b \030\036\031\035\034\ \021\026\021\024\r \035\036\004\036\027\017\016 \031\r\036\035\017\004\017\ \r\026\036\021\f\016 )Tj 0.08 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\f\035\031\004\026\016\b \023\030\036\007\r\026\030\017\021\036\035\034\027\ \024\005 \031\f\021\026\027\024\r\022\017 \007\030\036\027\017\030\031\033\ \013\036\005 )Tj 0.145 Tw T* [(\035\026\021\036\022\f\027\024\005 \035\017\020\026\021\031\030\t \(se)-12(t)17(on\) \007\024)]TJ /Span<>> BDC ( )Tj EMC (\r\n\036\001\026\021\036\035\034\f\021\r\026 \f)Tj /Span<>> BDC ( )Tj EMC (\017\f)Tj 0 Tw (-)Tj 0.182 Tw T* (\023\024\035\034\024\r\026\027\017\036\n \035\026\036\030\026, \026)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\032\036 \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \f\024 \f\r\017)Tj 0 Tw (-)Tj 0.149 Tw T* [(\013\036\r\t\n )0.5(\b\024\007\024\n )0.5(\007\035\017\027\024\005 )0.5(\n\036\027\036\036 )0.6(3 )0.5(\f\n )0.5([8]. )0.5(\216\026\030\026\022\021\036\030\017\031\016 )]TJ 0.109 Tw T* (\023\026\030\026\n\036\021\030\t \035\026\036\030\027\024\005 \022\024\026\ \020\031\035\016\006\017\017, \r)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\034\001\017\027\f\021\r\036 \017\f)Tj 0 Tw (-)Tj 0.107 Tw T* (\f\035\036\007\024\r\026\027\017\005 \017\f\023\024\035\034\024\r\026\035\ \026\f\034 \007\035\017\027\026 \r\024\035\027\t \017\035\031\004\036\027\ \017\016 )Tj 0.221 Tw T* (1470 \027\n \f)Tj /Span<>> BDC ( )Tj EMC (\n\024\013\027\024\f\021\034\033 8\22612)Tj /Span<>> BDC ( )Tj EMC (\200\021. \221\022\024\030\024\f\021\034 \023\030\024\r\036\007\036)Tj 0 Tw (-)Tj 0.182 Tw T* (\027\017\016 \f\r\036\021\024\r\024\007\026 \023\024)Tj /Span<>> BDC ( )Tj EMC (\f\r\017\013\036\r\024\n\031 \b\024\007\031 \022\024\035\036\002\026\035\ \026\f\034 \024\021 1 )Tj 0.081 Tw T* (\007\024)Tj /Span<>> BDC ( )Tj EMC (3)Tj /Span<>> BDC ( )Tj EMC (\n\n \r)Tj /Span<>> BDC ( )Tj EMC (\f\036\022\031\027\007\031. \025\026\022 \023\030\026\r\017\035\024, \024\ \023\036\030\026\006\017\016 \r\t\023\024\035\027\016)Tj 0 Tw (-)Tj -0.015 Tw T* (\035\026\f\034 \023\026\006\017\036\027\021\026\n \f)Tj /Span<>> BDC ( )Tj EMC (\021\030\026\027\f\f\235\017\027\022\021\036\030\027\t\n\017 \f\r\017\013\ \026\n\017, \030\036\032\036 )Tj 0.339 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\017\027\021\036\030- \017)Tj /Span<>> BDC ( )Tj EMC (\220\022\f\021\030\026\f\235\017\027\022\021\036\030\027\t\n\017 \f\r\017\ \013\026\n\017 \023\030\016\n\024\005 )Tj 0.142 Tw T* (\022\017\001\022\017. \210\021\007\036\035\034\027\t\036 \026\r\021\024\030\ \t \(\216\017\021\026\030\034\016\027)Tj /Span<>> BDC ( )Tj EMC (\202.\206., 2016\) \030\036)Tj 0 Tw (-)Tj 0.117 Tw T* (\022\024\n\036\027\007\024\r\026\035\017 \017\f\023\024\035\034\024\r\026\ \021\034 \024\023\036\030\026\006\017\033, \r)Tj /Span<>> BDC ( )Tj EMC (\021.\004. \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017)Tj 0 Tw (-)Tj 0.046 Tw T* (\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\027\026\035\017\004\017\036\n \023\026\030\026\030\036\022\021\026\035\034\ \027\t\b \026\021\036\022\024\r. \215\030\017)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\n )Tj ET 1 0.68 0 0.12 k /GS0 gs q 1 0 0 1 70.8661 695.7183 cm 0 0 m 0 0 l 0 -11.339 l 42.52 -11.339 l 42.52 0 l h f Q BT 0 0 0 0 k /T1_2 1 Tf 0 Tw 9 0 0 9 73.5728 686.791 Tm (ABSTRACT)Tj 1 0.68 0 0.12 k /T1_0 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\033\030\031\030\213\b)-20.9(\035\231\213\233\t \021\032)50(\b)42(\032\231\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj -51.938 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 23, \023\0221)69(, 202)69(4)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 23, \023\0221)69(, 202)69(4)]TJ /T1_5 1 Tf 25 0 0 25 28.115 56.0378 Tm (60)Tj ET endstream endobj 1944 0 obj [1948 0 R] endobj 1945 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\034\205\026\220\007\016\026\001\220\203 \025\221\020\026 \221\002\220\024\ \016\001\016\001\220\205 \024\016\026)11.1(\025\201\013 \007\013\222\016\002\001\025\203 \n)10(\025\013\202)-20(\215\007\205\227\220\220 )]TJ 0 -1 TD [(\221\002\220\022\007\016\017\016\001\220\220 \026\002\013\001\006- \220\022\ \232\n\006)-10(\026\002\013\006\225\220\001\n)-9.9(\026)11(\016\002\001\020\207 \006\r\220\224\016\203 \221\002\205\024\025\203 \n\220\ \n\220)]TJ 37.587 1 Td [(Fiv)12(e)-52(-y)10(ear e)21(xperience of laser coagulation in th)11(e tr)31(eatment )]TJ 6.214 -1 Td [(of tr)21.1(ans- and supr)21.1(asphincteric anal f)-20.9(istulas)]TJ ET 0 0 0 1 K 1 j 1 J [0 2.997]0 d /GS1 gs q 1 0 0 1 46.0167 213.4103 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 43.0197 213.4103 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q [0 2.997]0 d q 1 0 0 1 46.0167 176.2025 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 43.0197 176.2025 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q BT 0 0 0 1 k /T1_1 1 Tf 10 0 0 10 42.5197 724.8299 Tm (https://doi.org/10.33878/2073-7556-2024-23-1-59-70)Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 0.023 Tw 19 0 0 19 82.3136 695.3259 Tm [(\034\205\026\220\007\016\026\001\220\203 \025\221\020\026 \221\002\220\024\ \016\001\016\001\220\205 \024\016\026)11(\025\201\013 \007\013\222\016\002\001\025\203 )]TJ -1.32 -1.105 Td [(\n)10(\025\013\202)-20(\215\007\205\227\220\220 \221\002\220\022)-23.3(\007\016\017\016\001\220\220 \026\002\013\001\006- \220\022)-23.3(\232\n\006)-10(\026\002\013\006\225\220\001\n)-10(\026)11(\016\002\001\020\207 )]TJ 6.536 -1.105 Td (\006\r\220\224\016\203 \221\002\205\024\025\203 \n\220\n\220)Tj 0 0 0 1 k /GS1 gs 0 Tw 14 0 0 14 42.5197 628.822 Tm [(\037)31(\025\006)-10(\026)11(\013\002\016\r\022)-23.3(\030.\004.)]TJ -0.069 Tc 0.069 Tw 8.162 0 0 8.162 124.367 633.484 Tm [(1,)-69(2)]TJ 0 Tc 0.023 Tw 14 0 0 14 135.6876 628.822 Tm [(, \211\013\207)10(\013\002\205\001\022)-23.2(\b)-31(.\004.)]TJ 0 Tw 8.162 0 0 8.162 221.1926 633.484 Tm (1)Tj 0.023 Tw 14 0 0 14 225.8286 628.822 Tm [(, \037)20(\220\006\016\007\016\r\022)-23.2(\255.\036.)]TJ 0 Tw 8.162 0 0 8.162 311.9078 633.484 Tm (1)Tj 0.023 Tw 14 0 0 14 316.5437 628.822 Tm [(, \214\007\013\202)10(\025\201\013\002\001\020\203\022)-23.2(\035.\b)-31(.)]TJ 0 Tw 8.162 0 0 8.162 431.0282 633.484 Tm (2)Tj 14 0 0 14 435.6641 628.822 Tm (, )Tj -28.082 -1.143 Td [(\005\215\201\002\025\r\022)-23.2(\b)-31(.\b)-31(.)]TJ -0.069 Tc 0.069 Tw 8.162 0 0 8.162 118.9066 617.484 Tm [(1,)-69(2)]TJ 0 Tc 0.023 Tw 14 0 0 14 130.2272 612.822 Tm [(, \032)30(\220\026)11(\025\r\022)-23.2(\b)-31(.\200.)]TJ 0 Tw 8.162 0 0 8.162 203.7625 617.484 Tm (1)Tj 5.83 0 0 5.83 42.5197 598.4827 Tm (1)Tj 0.023 Tw 10 0 0 10 45.8311 595.1527 Tm [(\210\031\214)42(\240 \253\213\005\030\226 \n)10(\025\007\025\221\002\025\n)-9.9(\026)11(\025\007\025\202\220\220 \220\024\016\001\220 \b)-30.9(.\213.\022)-23.3(\033\020\217\220\207\273 \005\220\001\222\201\002\013\r\013 \033\025\006\ \006\220\220 \(\215\007.\022)-23.3(\021\013\007\205\024\013 \b)-20.9(\201\220\007\205, \201.\022)-23.3(2, \202)62.1(.\022)-23.3(\005\025\006\n\r\013, )]TJ -0.331 -1.2 Td [(1)125(23)58(423, \033\025\006\006\220\205\))]TJ 0 Tw ( )Tj 5.83 0 0 5.83 42.5197 574.4827 Tm (2)Tj 0.023 Tw 10 0 0 10 45.8311 571.1527 Tm [(\210\031\214)21(\036)20(\240 \255\034\036 \033)21(\005\b\213\034\036 \005\220\001\222\201\002\013\r\013 \033\025\006\006\220\ \220 \(\215\007.\022)-23.2(\214\013\002\002\220\n\013\201\001\013\205, \201.\022)-23.3(2/1)69(, \006)-10(\026\002)-31(.\022)-23.3(1)69(, \202)62(.\022)-23.2(\005\025\006\n\r\013, 1)125(2)23(5)23(99)35(3, \033\025\006\006\220\205\))]TJ /T1_1 1 Tf -0.026 Tw 9 0 0 9 90.7087 552.6488 Tm [(\037\036\035\034 \215\207\207\035\036\200\255\216\201\217\215\243: \025\016\ \205\006\025\024\022 \032\031\016\205\023\022\024\026\024\020 \004\025\032\ \205\032\202\025\006\031\t\013\n\202\n )0.5(\023\031\006\031\021\025\002 \033\026\203\025\031\021\024\n\027 \t)]TJ /Span<>> BDC ( )Tj EMC (\024\032\026\021\t- \025)Tj /Span<>> BDC ( )Tj EMC (\r\013\t\024\032\026\t\f\025\021\013\024\031\032)Tj 0 Tw (-)Tj 0.07 Tw 0 -1.111 TD (\021\020\003\025 \t\027\025\211\026\003\025 \033\032\002\003\n\017 \013\025\ \001\013\025 \t)Tj /Span<>> BDC ( )Tj EMC (\025\t\033\n\023\022\016\n\027\026\021\025\031\003 \023\026\016\031\032\021\ \n\017 \013\n\026\202\205\023\002\203\025\025 \027)Tj /Span<>> BDC ( )Tj EMC (\016\026\027\025\t\025\003\n\t\024\025 \n\024 \t\033\n\t\n\005\026 \016\026\ \013\032\020\024\025\002 )Tj 0.023 Tw T* (\027\021\205\024\032\031\021\021\031\202\n \t\027\025\211\031\027\n\202\n\ \n\024\027\031\032\t\024\025\002.)Tj 0.067 Tw T* (\201\037\215\036\217\220\235 \215)Tj /Span<>> BDC ( )Tj EMC (\240\036\220\255\200\235: \016\026)Tj /Span<>> BDC ( )Tj EMC (5-\023\031\024\021\025\017 \033\031\032\025\n\030 121 \033\026\203\025\031\ \021\024\205 \027\020\033\n\023\021\031\021\020 \n\033\031\032\026\024\025\ \027\021\020\031 \027\003\031\001\026\024\031\023\022\t\024\027\026 \t)Tj /Span<>> BDC ( )Tj EMC (\033\032\025)Tj 0 Tw (-)Tj 0.084 Tw T* [(\003\031\021\031\021\025\031\003 )0.6(\023\026\016\031\032\021\n\017 )0.5(\013\n\026\202\205\023\002\203\025\025 )0.6(\t\027\025\211\031\027\n\202\n )0.6(\004\n\030\026 )0.5(\027)]TJ /Span<>> BDC ( )Tj EMC 21.027 0 Td [(\t\n\006\031\024\026\021\025\025 )0.6(\t)]TJ /Span<>> BDC ( )Tj EMC 5.505 0 Td [(3 )0.5(\032\026\016\023\025\006\021\020\003\025 )0.5(\027\026\032\025\026\021\024\026\003\025 )0.5(\016\026\013\032\020\024\025\002 )0.5(\027\021\205\024)]TJ 0 Tw (-)Tj 0.061 Tw -26.532 -1.111 Td (\032\031\021\021\031\202\n \t\027\025\211\031\027\n\202\n \n\024\027\031\ \032\t\024\025\002.43 \033\026\203\025\031\021\024\026 \005\020\023\025 \ \027\013\023\007\006\031\021\020 \027)Tj /Span<>> BDC ( )Tj EMC (\202\032\205\033\033\205 \023\026\016\031\032\021\n\017 \013\n\026\202\205\ \023\002\203\025\025 \t\027\025\211\031\027\n\202\n \004\n\030\026 )Tj 0.041 Tw T* (\027)Tj /Span<>> BDC ( )Tj EMC (\t\n\006\031\024\026\021\025\025 \t)Tj /Span<>> BDC ( )Tj EMC (\031\202\n \033\031\032\031\027\002\016\013\n\017 \027)Tj /Span<>> BDC ( )Tj EMC (\003\031\204\t\f\025\021\013\024\031\032\021\n\003 \033\032\n\t\024\032\026\ \021\t\024\027\031 \(\035\220)Tj /Span<>> BDC ( )Tj EMC (+)Tj /Span<>> BDC ( )Tj EMC (\207\240\), 47)Tj /Span<>> BDC ( )Tj EMC (\227 \027)Tj /Span<>> BDC ( )Tj EMC (\202\032\205\033\033\205 \023\026\016\031\032\021\n\017 \013\n\026)Tj 0 Tw (-)Tj 0.033 Tw T* (\202\205\023\002\203\025\025 \t\027\025\211\026 \t)Tj /Span<>> BDC ( )Tj EMC (\033\023\026\t\024\025\013\n\017 \027\021\205\024\032\031\021\021\031\202\ \n \t\027\025\211\031\027\n\202\n \n\024\027\031\032\t\024\025\002 \t\023\ \025\016\025\t\024\n-\003\020\001\031\006\021\020\003 \023\n\t\013\205\024\ \n\003 \(\035\220)Tj /Span<>> BDC ( )Tj EMC (+)Tj /Span<>> BDC ( )Tj EMC (\207\240\035\), )Tj 0.022 Tw T* (31)Tj /Span<>> BDC ( )Tj EMC (\227 \027)Tj /Span<>> BDC ( )Tj EMC (\202\032\205\033\033\205 \023\026\016\031\032\021\n\017 \024\031\032\003\ \n\013\n\026\202\205\023\002\203\025\025 \t\027\025\211\031\027\n\202\n \ \004\n\030\026 \t)Tj /Span<>> BDC ( )Tj EMC (\205\001\025\027\026\021\025\031\003 \027\021\205\024\032\031\021\021\031\ \202\n \t\027\025\211\031\027\n\202\n \n\024\027\031\032\t\024\025\002 )Tj 0.037 Tw T* (\n\024\030\031\023\022\021\020\003\025 \001\027\026\003\025 \(\035\220)Tj /Span<>> BDC ( )Tj EMC (+)Tj /Span<>> BDC ( )Tj EMC (\214\216\207\). \207\032\031\030\021\025\017 \027\n\016\032\026\t\024 \033\ \026\203\025\031\021\024\n\027)Tj /Span<>> BDC ( )Tj EMC (\227 42 \(20\22670\) \202\n\030\026. \240\205\204\006\025\021)Tj /Span<>> BDC ( )Tj EMC (\227 82, \204\031\021\211\025\021)Tj /Span<>> BDC ( )Tj EMC (\227 )Tj 0.041 Tw T* (39. \207\032\031\030\021\025\017 \033\031\032\025\n\030 \021\026\005\023\ \007\030\031\021\025\002 \016\026)Tj /Span<>> BDC ( )Tj EMC (\033\026\203\025\031\021\024\026\003\025 \t\n\t\024\026\027\025\023 19 \(\ 3\22652\) \003\031\t\002\203\031\027. \216)Tj /Span<>> BDC ( )Tj EMC (\033\031\032\025\n\033\031\032\026\203\025\n\021\021\n\003 \033\031\032\025\ \n\030\031 )Tj -0.032 Tw T* [(\(\030\n )0.5(\n\033\031\032\026\203\025\025, )0.6(\006\031\032\031\016 )0.5(1 )0.5(\025)]TJ /Span<>> BDC ( )Tj EMC 9.731 0 Td [(2 )0.5(\003\031\t\002\203\026 )0.5(\033\n\t\023\031 )0.5(\027\003\031\001\026\024\031\023\022\t\024\027\026\) )0.6(\033\026\203\025\031\021\024\026\003 )0.6(\027\020\033\n\023\021\002\023\t\002 )0.5(\214\221\215 )0.5(\003\n\021\025\024\n\032\025\021\202 )0.5(\030\023\002 )0.5(\n\203\031\021\013\025 )]TJ 0.1 Tw -9.731 -1.111 Td (\033\032\n\203\031\t\t\026 \016\026\204\025\027\023\031\021\025\002 \t\027\ \025\211\031\017 \025)Tj /Span<>> BDC ( )Tj EMC (\032\026\021\021\031\202\n \027\020\002\027\023\031\021\025\002 \032\031\ \203\025\030\025\027\n\027 \016\026\005\n\023\031\027\026\021\025\002. \200\ \023\002 \n\203\031\021\013\025 \027\023\025\002\021\025\002 \n\033\031\032\ \026\203\025\017 )Tj -0.034 Tw T* (\021\026)Tj /Span<>> BDC ( )Tj EMC (\f\205\021\013\203\025\n\021\026\023\022\021\n\031 \t\n\t\024\n\002\021\025\ \031 \016\026\033\025\032\026\024\031\023\022\021\n\202\n \026\033\033\026\ \032\026\024\026 \033\032\002\003\n\017 \013\025\001\013\025 \030\n)Tj /Span<>> BDC ( )Tj EMC (\027\003\031\001\026\024\031\023\022\t\024\027\026 \025)Tj /Span<>> BDC ( )Tj EMC (\006\031\032\031\016 3 \003\031\t\002\203\026 )Tj 0.023 Tw 0 -1.111 TD (\033\n\t\023\031 \n\033\031\032\026\203\025\025 \033\026\203\025\031\021\ \024\026\003 \027\020\033\n\023\021\002\023\026\t\022 \t\f\025\021\013\024\ \031\032\n\003\031\024\032\025\002.)Tj 0.259 Tw 0 -1.111 TD (\212\036\221\214\035\034\220\201\220\235: \027)Tj /Span<>> BDC ( )Tj EMC (\202\032\205\033\033\031 \035\220)Tj /Span<>> BDC ( )Tj EMC (+)Tj /Span<>> BDC ( )Tj EMC (\207\240 \016\026\204\025\027\023\031\021\025\031 \t\027\025\211\026 \n\ \024\003\031\006\031\021\n \205)Tj /Span<>> BDC ( )Tj EMC (33/43)Tj /Span<>> BDC ( )Tj EMC (\(76,7%\) \033\026\203\025\031\021\024\n\027, \027)Tj /Span<>> BDC ( )Tj EMC (\202\032\205\033\033\031 )Tj 0.145 Tw T* (\035\220)Tj /Span<>> BDC ( )Tj EMC (+)Tj /Span<>> BDC ( )Tj EMC (\207\240\035)Tj /Span<>> BDC ( )Tj EMC (\227 \205)Tj /Span<>> BDC ( )Tj EMC (33/47 \(70,2%\) \033\026\203\025\031\021\024\n\027, \027)Tj /Span<>> BDC ( )Tj EMC (\202\032\205\033\033\031 \035\220)Tj /Span<>> BDC ( )Tj EMC (+)Tj /Span<>> BDC ( )Tj EMC (\214\216\207)Tj /Span<>> BDC ( )Tj EMC (\227 \205)Tj /Span<>> BDC ( )Tj EMC (17/31)Tj /Span<>> BDC ( )Tj EMC (\(54,8%\) \033\026\203\025\031\021\024\n\027 \(\032)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,129\). )Tj 0.002 Tc 0.349 Tw T* [(\036)0.5(\030)0.6(\025)0.6(\021)0.5(\t)0.6(\024)0.5(\027)0.6(\031)0.5(\021)0.6(\021)0.6(\020)0.5(\003)0.6( \205)0.6(\t)0.6(\024)0.5(\026)0.6(\021)0.5(\n)0.6(\027)0.6(\023)0.5(\031)0.6(\021)0.5(\021)0.6(\020)0.5(\003)0.6( \f)0.5(\026)0.6(\013)0.5(\024)0.6(\n)0.6(\032)0.5(\n)0.6(\003)0.5(,)0.6( \033)0.5(\032)0.6(\n)0.5(\030)0.6(\031)0.5(\003)0.6(\n)0.5(\021)0.6(\t)0.6(\024)0.5(\032)0.6(\025)0.5(\032)0.6(\n)0.5(\027)0.6(\026)0.5(\027)0.6(\001)0.6(\025)0.5(\003)0.6( \t)0.6(\024)0.6(\026)0.5(\024)0.6(\025)0.5(\t)0.6(\024)0.5(\025)0.6(\006)0.5(\031)0.6(\t)0.6(\013)0.5(\025)0.6( \016)0.5(\021)0.6(\026)0.5(\006)0.6(\025)0.5(\003)0.6(\n)0.5(\031)0.6( \027)0.5(\023)0.6(\025)0.6(\002)0.5(\021)0.6(\025)0.5(\031)2( )]TJ 0 Tc 0.092 Tw T* (\021\026)Tj /Span<>> BDC ( )Tj EMC (\006\026\t\024\n\024\205 \033\n\023\n\204\025\024\031\023\022\021\020\004\ \032\031\016\205\023\022\024\026\024\n\027 \027)Tj /Span<>> BDC ( )Tj EMC (\202\032\205\033\033\031 \035\220)Tj /Span<>> BDC ( )Tj EMC (+)Tj /Span<>> BDC ( )Tj EMC (\207\240, \n\013\026\016\026\023\t\002 \030\025\026\003\031\024\032 \027\ \021\205\024\032\031\021\021\031\202\n \t\027\025\211\031\027\n\202\n )Tj 0.065 Tw T* (\n\024\027\031\032\t\024\025\002. \220\026\013, \033\032\025)Tj /Span<>> BDC ( )Tj EMC (\030\025\026\003\031\024\032\031 \t\027\025\211\031\027\n\202\n \n\024\027\ \031\032\t\024\025\002 \005\n\023\031\031 3 \003\003 \033\n\023\n\204\025\ \024\031\023\022\021\020\017 \032\031\016\205\023\022\024\026\024 \005\020\ \023 \030\n\t\024\025\202)Tj 0 Tw (-)Tj 0.065 Tw T* (\021\205\024 \205)Tj /Span<>> BDC ( )Tj EMC (24)Tj /Span<>> BDC ( )Tj EMC (\(54,5%\) \025\016)Tj /Span<>> BDC ( )Tj EMC (44 \033\026\203\025\031\021\024\n\027, \026)Tj /Span<>> BDC ( )Tj EMC (\033\032\025 \030\025\026\003\031\024\032\031 \n\024\027\031\032\t\024\025\ \002)Tj /Span<>> BDC ( )Tj EMC (\244)Tj /Span<>> BDC ( )Tj EMC (3,0 \003\003 \t\027\025\211\031\027\n\017 \004\n\030 \016\026\204\025\023\ \027)Tj /Span<>> BDC ( )Tj EMC (58)Tj /Span<>> BDC ( )Tj EMC (\(75,3%\) )Tj 0.091 Tw T* (\025\016)Tj /Span<>> BDC ( )Tj EMC (77 \021\026\005\023\007\030\031\021\025\017 \(\032)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC [(0,025\).\207\032\031\030\021\002\002 \033\032\n\030\n\023\204\025\024\031\ \023\022\021\n\t\024\022 )0.5(\013\n\017\013\n-\030\021\002 \(\240\031\) \t\n\t\024\026\027\025\023\026\ 3,5. \255\t\023\n\204\021\031\021\025\002 \027\n )]TJ 0.023 Tw T* (\027\032\031\003\002 \n\033\031\032\026\203\025\025 \025)Tj /Span<>> BDC ( )Tj EMC (\005\023\025\204\026\017\001\031\003 \033\n\t\023\031\n\033\031\032\026\203\ \025\n\021\021\n\003 \033\031\032\025\n\030\031 \016\026\f\025\013\t\025\ \032\n\027\026\021\020 \023\025\001\022 \027)Tj /Span<>> BDC ( )Tj EMC (3 \(2,5%\) \t\023\205\006\026\002\004.)Tj 0.092 Tw 0 -1.111 TD (\221\201\222\035\223\224\036\217\215\036: \003\031\024\n\030 \023\026\016\ \031\032\021\n\017 \013\n\026\202\205\023\002\203\025\025 \016\026\032\031\ \013\n\003\031\021\030\n\027\026\023 \t\031\005\002 \027)Tj /Span<>> BDC ( )Tj EMC (\013\026\006\031\t\024\027\031 \t\f\025\021\013\024\031\032\n\t\005\031\032\ \031\202\026\007\211\031\202\n \027\003\031)Tj 0 Tw (-)Tj 0.236 Tw 0 -1.111 TD (\001\026\024\031\023\022\t\024\027\026, \t\033\n\t\n\005\021\n\202\n \t\n\ \t\024\026\027\025\024\022 \013\n\021\013\205\032\031\021\203\025\007 \030\ \023\002 \024\032\026\030\025\203\025\n\021\021\020\004 \t\033\n\t\n\005\ \n\027 \023\031\006\031\021\025\002 \t\027\025\211\031\017 \033\032\002\003\ \n\017 )Tj 0.131 Tw T* (\013\025\001\013\025 \027)Tj /Span<>> BDC ( )Tj EMC (\n\024\n\005\032\026\021\021\n\017 \202\032\205\033\033\031 \033\026\203\ \025\031\021\024\n\027. \216\021\031 \016\026\027\025\t\025\003\n\t\024\025\ \n\024 \t\033\n\t\n\005\026 \016\026\013\032\020\024\025\002 \027\021\205\ \024\032\031\021\021\031\202\n \t\027\025\211\031\027\n\202\n )Tj 0.04 Tw T* (\n\024\027\031\032\t\024\025\002 \003\031\024\n\030\025\013\026 \033\032\ \n\030\031\003\n\021\t\024\032\025\032\n\027\026\023\026 \027\020\t\n\013\ \025\017 \205\032\n\027\031\021\022 \005\031\016\n\033\026\t\021\n\t\024\ \025. \217\026\025\023\205\006\001\025\031 \033\n\013\026\016\026\024\031\ \023\025 \006\026\t\024\n)Tj 0 Tw (-)Tj 0.12 Tw T* (\024\020 \016\026\204\025\027\023\031\021\025\002 \016\026\f\025\013\t\025\ \032\n\027\026\021\020 \033\032\025)Tj /Span<>> BDC ( )Tj EMC (\t\n\006\031\024\026\021\025\025 \023\026\016\031\032\021\n\017 \013\n\026\ \202\205\023\002\203\025\025 \t)Tj /Span<>> BDC ( )Tj EMC (\033\031\032\031\027\002\016\013\n\017 \t\027\025\211\031\027\n\202\n \004\ \n\030\026 \027)Tj /Span<>> BDC ( )Tj EMC (\003\031\204)Tj 0 Tw (-)Tj 0.066 Tw T* (\t\f\025\021\013\024\031\032\021\n\003 \033\032\n\t\024\032\026\021\t\024\ \027\031 \(76,7%\), \n\030\021\026\013\n \033\n\025\t\013 \021\026\025\005\ \n\023\031\031 \021\026\030\031\204\021\n\202\n \t\033\n\t\n\005\026 \025\ \016\n\023\002\203\025\025 \t\027\025\211\031\027\n\202\n \004\n\030\026\ )Tj 0.023 Tw T* (\n\024 \033\032\n\t\027\031\024\026 \033\032\002\003\n\017 \013\025\001\013\ \025 \030\n\023\204\031\021 \005\020\024\022 \033\032\n\030\n\023\204\031\ \021.)Tj /T1_2 1 Tf 0.01 Tc 0.015 Tw 8 0 0 8 42.5596 247.3795 Tm [(\037\036\035\034\033\032\031\033)5( )0.6(\030\036\027\032\026:)]TJ /T1_1 1 Tf 0 Tc 0.02 Tw 8.489 0 Td [( )0.5(\t\027\025\211 )0.6(\033\032\002\003\n\017 )0.6(\013\025\001\013\025, )0.6(\023\026\016\031\032\021\026\002 )0.7(\013\n\026\202\205\023\002\203\025\002, )0.6(\033\031\032\031\027\002\016\013\026 )0.6(\t\027\025\211\031\027\n\202\n )0.6(\004\n\030\026 )0.6(\027)]TJ /Span<>> BDC ( )Tj EMC 29.898 0 Td [(\003\031\204\t\f\025\021\013\024\031\032\021\n\003 )0.7(\033\032\n\t\024\032\026\021\t\024\027\031, )0.6(\t\023\025\016\025\t\024\n-)]TJ 0.023 Tw -38.392 -1.2 Td (\003\020\001\031\006\021\020\017 \023\n\t\013\205\024, FiLaC)Tj /T1_2 1 Tf 0.01 Tc 0.018 Tw 0.005 -1.909 Td [(\037\027\025\024\036\023\037\022)5( \023\025\022\033\021\033\030\027\032:)]TJ /T1_1 1 Tf 0 Tc 0.023 Tw 10.401 0 Td ( \026\027\024\n\032\020 \016\026\002\027\023\002\007\024 \n\005 \n\024\t\ \205\024\t\024\027\025\025 \013\n\021\f\023\025\013\024\026 \025\021\024\ \031\032\031\t\n\027)Tj /T1_2 1 Tf 0.033 Tc -0.005 Tw -10.401 -2.617 Td [(\020\036\017)4.7( \016\023\022\023\021\027\032\026\025\023\017:)]TJ /T1_3 1 Tf 0.023 Tc 0 Tw 9.167 0 Td ( \025\024\f\021\026\030\036\r)Tj /Span<>> BDC ( )Tj EMC (\222.\200., \003\026\b\026\030\016\027)Tj /Span<>> BDC ( )Tj EMC (\202.\200., \025\017\f\036\035\036\r)Tj /Span<>> BDC ( )Tj EMC (\212.\210., \207\035\026\020\024\007\026\030\027\t\005)Tj /Span<>> BDC ( )Tj EMC (\214.\202., \204\031\007\030\024\r)Tj /Span<>> BDC ( )Tj EMC (\202.\202., \230\017\021\024\r)Tj /Span<>> BDC ( )Tj EMC (\202.\236. \215\016\021\017\035\036\021\027\017\005 \024\023\t\021 \023\030\ \017)Tj 0 Tc (-)Tj 0.023 Tc 0.041 Tw -9.172 -1.2 Td (\n\036\027\036\027\017\016 \n\036\021\024\007\026 \035\026\036\030\027\024\ \005 \022\024\026\020\031\035\016\006\017\017 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\035\036\004\036\027\017\017 \021\030\026\027\f- \017)Tj /Span<>> BDC ( )Tj EMC (\220\022\f\021\030\026\f\235\017\027\022\021\036\030\027\t\b \f\r\017\013\ \036\005 \023\030\016\n\024\005 \022\017\001\022\017. )Tj /T1_1 1 Tf -0.023 Tw (\222\n\023\n\033\032\n\013\024\n\023\n\202\025\002.)Tj /T1_3 1 Tf 0.041 Tw [( 2024;)23( )]TJ 0.024 Tw 0 -1.2 TD (\021.)Tj /Span<>> BDC ( )Tj EMC (23, \225)Tj /Span<>> BDC ( )Tj EMC [(1, )0.5(\f.)]TJ /Span<>> BDC ( )Tj EMC (59\22670. https://doi.org/10.33878/2073-7556-2024-23-1-59-70)Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 0 Tc 0.023 Tw 18 0 0 18 97.5317 150.0332 Tm [(Fiv)12(e)-52(-y)10(ear e)21(xperience of laser coagulation in th)11.1(e )]TJ -0.834 -1.167 Td [(tr)31(eatment of tr)21(ans- and supr)21(asphincteric anal f)-21(istulas)]TJ 0 0 0 1 k /GS1 gs 0 Tw 14 0 0 14 42.5197 104.5292 Tm [(Iv)10(an\022)-23.3(V)62(.\022)-23.2(K)40.9(ostar)31(e)11(v)]TJ -0.069 Tc 0.069 Tw 8.162 0 0 8.162 132.7432 109.1912 Tm [(1,)-69(2)]TJ 0 Tc 0.023 Tw 14 0 0 14 144.0638 104.5292 Tm [(, Ale)21(x)11(ander\022)-23.2(V)62(.\022)-23.3(Z)21(akhar)-30.9(y)21(an)]TJ 0 Tw 8.162 0 0 8.162 289.9677 109.1912 Tm (1)Tj 0.023 Tw 14 0 0 14 294.6037 104.5292 Tm [(, Dmitr)-30.9(y\022)-23.3(O.\022)-23.3(Kisele)11.1(v)]TJ 0 Tw 8.162 0 0 8.162 400.678 109.1912 Tm (1)Tj 14 0 0 14 405.3139 104.5292 Tm (, )Tj -25.914 -1.143 Td [(Leonid\022)-23.2(A)-31(.\022)-23.3(Blagodarny)]TJ 8.162 0 0 8.162 165.5999 93.1912 Tm (2)Tj 0.023 Tw 14 0 0 14 170.2359 88.5292 Tm [(, Andr)31(ey\022)-23.2(A)-31(.\022)-23.3(Mudr)20(ov)]TJ -0.069 Tc 0.069 Tw 8.162 0 0 8.162 283.9126 93.1912 Tm [(1,)-69(2)]TJ 0 Tc 0.023 Tw 14 0 0 14 295.2332 88.5292 Tm [(, Ale)21(x)11(ander\022)-23.2(Y)40(u.\022)-23.3(Titov)]TJ 0 Tw 8.162 0 0 8.162 412.5217 93.1912 Tm (1)Tj ET 1 0.68 0 0.12 k /GS0 gs q 1 0 0 1 42.5197 561.1533 cm 0 0 m 0 0 l 0 -11.339 l 42.52 -11.339 l 42.52 0 l h f Q BT 0 0 0 0 k /T1_2 1 Tf 9 0 0 9 47.6607 552.226 Tm (\021\033\r\035\f\033)Tj 1 0.68 0 0.12 k /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\033\030\031\030\213\b)-20.9(\035\231\213\233\t \021\032)50(\b)42(\032\231\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj /T1_4 1 Tf 25 0 0 25 512.7895 56.0378 Tm (59)Tj ET q 0 g 0 G 0 j 0 J /Fm1 Do Q 0 0 0 0 k 368.504 725.67 59.155 11.338 re f /PlacedPDF /MC0 BDC q 369.135 736.808 m 368.896 736.808 368.703 736.616 368.703 736.376 c 368.703 736.376 l 368.703 726.285 l 368.703 726.045 368.896 725.853 369.135 725.853 c 369.135 725.853 l 427.035 725.853 l 427.273 725.853 427.469 726.045 427.469 726.285 c 427.469 726.285 l 427.469 736.376 l 427.469 736.616 427.273 736.808 427.035 736.808 c 427.035 736.808 l h W n q 0 g -0.0000005 -10.9560913 -10.9560913 0.0000005 398.0855785 736.8086309 cm BX /Sh0 sh EX Q Q q 368.504 725.67 59.155 11.337 re W n 0 0 0 0.84 k q 1 0 0 1 385.2169 732.4249 cm 0 0 m -0.025 0.1 -0.063 0.196 -0.112 0.287 c -0.157 0.374 -0.218 0.451 -0.292 0.515 c -0.37 0.582 -0.46 0.632 -0.558 0.664 c -0.669 0.701 -0.786 0.719 -0.903 0.717 c -1.076 0.722 -1.247 0.681 -1.4 0.6 c -1.536 0.526 -1.652 0.42 -1.74 0.292 c -1.83 0.158 -1.895 0.008 -1.934 -0.149 c -2.018 -0.48 -2.018 -0.827 -1.934 -1.158 c -1.896 -1.316 -1.83 -1.466 -1.74 -1.602 c -1.653 -1.731 -1.536 -1.837 -1.4 -1.912 c -1.247 -1.993 -1.076 -2.033 -0.903 -2.029 c -0.774 -2.032 -0.647 -2.006 -0.528 -1.955 c -0.427 -1.906 -0.337 -1.837 -0.263 -1.753 c -0.185 -1.665 -0.124 -1.563 -0.082 -1.453 c -0.034 -1.338 0 -1.218 0.019 -1.094 c 0.635 -1.094 l 0.624 -1.297 0.578 -1.497 0.497 -1.684 c 0.421 -1.857 0.312 -2.015 0.175 -2.146 c 0.039 -2.277 -0.123 -2.379 -0.3 -2.446 c -0.492 -2.519 -0.695 -2.555 -0.9 -2.552 c -1.15 -2.557 -1.397 -2.506 -1.625 -2.404 c -1.829 -2.307 -2.01 -2.169 -2.157 -1.997 c -2.308 -1.821 -2.423 -1.617 -2.497 -1.397 c -2.655 -0.924 -2.655 -0.412 -2.497 0.061 c -2.423 0.281 -2.307 0.485 -2.157 0.661 c -2.01 0.833 -1.829 0.973 -1.625 1.07 c -1.398 1.174 -1.15 1.226 -0.9 1.222 c -0.707 1.223 -0.515 1.196 -0.329 1.14 c -0.159 1.088 0.001 1.006 0.144 0.898 c 0.278 0.793 0.39 0.662 0.473 0.513 c 0.562 0.349 0.615 0.167 0.629 -0.019 c 0 -0.019 l 0 0 l f Q q 1 0 0 1 386.3458 733.5723 cm 0 0 m 0.584 0 l 0.584 -1.328 l 0.662 -1.204 0.771 -1.103 0.9 -1.033 c 1.046 -0.951 1.213 -0.91 1.381 -0.914 c 1.627 -0.9 1.869 -0.979 2.058 -1.137 c 2.234 -1.312 2.325 -1.556 2.305 -1.803 c 2.305 -3.596 l 1.716 -3.596 l 1.716 -1.976 l 1.724 -1.817 1.678 -1.66 1.585 -1.53 c 1.486 -1.43 1.347 -1.379 1.206 -1.392 c 1.114 -1.39 1.024 -1.408 0.94 -1.445 c 0.865 -1.479 0.798 -1.529 0.744 -1.591 c 0.687 -1.656 0.645 -1.73 0.616 -1.812 c 0.586 -1.896 0.571 -1.986 0.571 -2.077 c 0.571 -3.615 l 0 -3.615 l 0 0 l f Q q 1 0 0 1 389.692 731.1235 cm 0 0 m 0 -0.099 0.014 -0.198 0.043 -0.292 c 0.069 -0.382 0.112 -0.466 0.17 -0.54 c 0.229 -0.611 0.304 -0.669 0.388 -0.709 c 0.486 -0.754 0.594 -0.776 0.702 -0.773 c 0.845 -0.78 0.987 -0.742 1.108 -0.664 c 1.217 -0.582 1.296 -0.468 1.336 -0.337 c 1.881 -0.337 l 1.827 -0.603 1.675 -0.838 1.456 -0.996 c 1.35 -1.073 1.231 -1.131 1.105 -1.169 c 0.971 -1.208 0.831 -1.229 0.691 -1.227 c 0.509 -1.227 0.328 -1.191 0.16 -1.121 c 0.007 -1.063 -0.13 -0.972 -0.244 -0.855 c -0.356 -0.73 -0.44 -0.583 -0.491 -0.422 c -0.548 -0.243 -0.576 -0.056 -0.574 0.133 c -0.575 0.313 -0.545 0.493 -0.486 0.664 c -0.426 0.826 -0.335 0.974 -0.22 1.102 c 0.004 1.375 0.338 1.534 0.691 1.535 c 0.883 1.539 1.072 1.495 1.243 1.408 c 1.402 1.326 1.541 1.209 1.649 1.067 c 1.759 0.922 1.838 0.757 1.883 0.582 c 1.932 0.396 1.945 0.203 1.92 0.013 c 0 0.013 l 0 0 l 1.342 0.377 m 1.335 0.468 1.315 0.557 1.283 0.643 c 1.253 0.724 1.209 0.798 1.153 0.863 c 1.097 0.922 1.03 0.97 0.957 1.004 c 0.874 1.043 0.783 1.063 0.691 1.062 c 0.6 1.062 0.509 1.044 0.425 1.009 c 0.345 0.976 0.273 0.926 0.213 0.863 c 0.153 0.799 0.105 0.724 0.072 0.643 c 0.037 0.559 0.017 0.468 0.014 0.377 c 1.355 0.377 l h f Q q 1 0 0 1 393.8116 731.7051 cm 0 0 m -0.012 0.144 -0.082 0.276 -0.194 0.366 c -0.31 0.452 -0.451 0.495 -0.595 0.489 c -0.675 0.488 -0.755 0.476 -0.831 0.452 c -0.918 0.424 -0.998 0.375 -1.062 0.311 c -1.142 0.229 -1.202 0.131 -1.24 0.024 c -1.29 -0.132 -1.312 -0.296 -1.304 -0.459 c -1.304 -0.569 -1.292 -0.677 -1.267 -0.784 c -1.244 -0.885 -1.202 -0.983 -1.145 -1.07 c -1.09 -1.154 -1.016 -1.224 -0.93 -1.275 c -0.833 -1.33 -0.722 -1.356 -0.611 -1.352 c -0.457 -1.357 -0.307 -1.301 -0.194 -1.195 c -0.078 -1.077 -0.005 -0.922 0.011 -0.757 c 0.587 -0.757 l 0.556 -1.055 0.419 -1.332 0.202 -1.538 c -0.022 -1.721 -0.306 -1.815 -0.595 -1.803 c -0.777 -1.806 -0.958 -1.771 -1.126 -1.7 c -1.293 -1.642 -1.445 -1.547 -1.57 -1.421 c -1.68 -1.297 -1.763 -1.151 -1.814 -0.993 c -1.87 -0.822 -1.898 -0.643 -1.896 -0.462 c -1.898 -0.276 -1.871 -0.091 -1.817 0.087 c -1.766 0.252 -1.682 0.405 -1.57 0.537 c -1.459 0.664 -1.323 0.766 -1.168 0.834 c -0.991 0.914 -0.798 0.955 -0.603 0.954 c -0.457 0.954 -0.311 0.935 -0.17 0.895 c -0.039 0.858 0.084 0.799 0.194 0.72 c 0.302 0.643 0.393 0.543 0.459 0.428 c 0.531 0.298 0.572 0.155 0.582 0.008 c 0 0.008 l 0 0 l f Q q 1 0 0 1 394.8712 733.5723 cm 0 0 m 0.577 0 l 0.577 -2.048 l 1.615 -0.985 l 2.322 -0.985 l 1.323 -1.944 l 2.417 -3.604 l 1.716 -3.604 l 0.919 -2.337 l 0.577 -2.669 l 0.577 -3.604 l 0 -3.604 l h f Q q 1 0 0 1 398.712 732.5762 cm 0 0 m 0.436 0 l 0.436 0.218 l 0.429 0.352 0.448 0.486 0.488 0.614 c 0.521 0.705 0.577 0.786 0.651 0.85 c 0.717 0.905 0.795 0.943 0.879 0.961 c 0.966 0.979 1.056 0.988 1.145 0.988 c 1.28 0.993 1.416 0.981 1.548 0.954 c 1.548 0.505 l 1.509 0.516 1.469 0.523 1.429 0.528 c 1.379 0.532 1.33 0.532 1.28 0.528 c 1.209 0.53 1.14 0.511 1.081 0.473 c 1.019 0.419 0.987 0.337 0.999 0.255 c 0.999 -0.011 l 1.498 -0.011 l 1.498 -0.441 l 1.009 -0.441 l 1.009 -2.622 l 0.436 -2.622 l 0.436 -0.428 l 0.005 -0.428 l 0.005 0 l 0 0 l f Q q 1 0 0 1 401.7535 729.8965 cm 0 0 m -0.191 -0.003 -0.381 0.032 -0.559 0.104 c -0.715 0.167 -0.856 0.264 -0.972 0.388 c -1.091 0.512 -1.181 0.659 -1.238 0.82 c -1.356 1.18 -1.356 1.567 -1.238 1.925 c -1.181 2.087 -1.091 2.234 -0.972 2.358 c -0.856 2.481 -0.715 2.578 -0.559 2.643 c -0.199 2.78 0.198 2.78 0.558 2.643 c 0.714 2.578 0.855 2.481 0.972 2.358 c 1.09 2.234 1.181 2.087 1.237 1.925 c 1.355 1.567 1.355 1.18 1.237 0.82 c 1.181 0.659 1.09 0.512 0.972 0.388 c 0.855 0.266 0.713 0.169 0.558 0.106 c 0.38 0.034 0.191 -0.002 0 0 c 0 0.454 m 0.115 0.451 0.23 0.479 0.332 0.534 c 0.424 0.586 0.502 0.659 0.562 0.746 c 0.624 0.836 0.669 0.936 0.695 1.041 c 0.752 1.26 0.752 1.491 0.695 1.71 c 0.669 1.816 0.625 1.916 0.562 2.005 c 0.502 2.091 0.423 2.163 0.332 2.215 c 0.123 2.323 -0.126 2.323 -0.335 2.215 c -0.427 2.163 -0.505 2.091 -0.566 2.005 c -0.628 1.916 -0.673 1.816 -0.699 1.71 c -0.756 1.491 -0.756 1.26 -0.699 1.041 c -0.672 0.936 -0.627 0.836 -0.566 0.746 c -0.506 0.659 -0.427 0.586 -0.335 0.534 c -0.232 0.478 -0.117 0.451 0 0.454 c f Q q 1 0 0 1 403.5515 732.5762 cm 0 0 m 0.531 0 l 0.531 -0.505 l 0.55 -0.43 0.583 -0.359 0.629 -0.297 c 0.681 -0.229 0.74 -0.167 0.807 -0.114 c 0.877 -0.059 0.956 -0.014 1.039 0.019 c 1.123 0.053 1.213 0.07 1.304 0.069 c 1.52 0.069 l 1.52 -0.486 l 1.395 -0.467 l 1.269 -0.467 l 1.178 -0.468 1.087 -0.488 1.004 -0.526 c 0.917 -0.565 0.839 -0.625 0.778 -0.699 c 0.716 -0.783 0.669 -0.878 0.643 -0.98 c 0.604 -1.104 0.584 -1.233 0.586 -1.362 c 0.586 -2.603 l 0.01 -2.603 l 0.01 0 l 0 0 l f Q q 1 0 0 1 409.0202 729.9683 cm 0 0 m -0.577 0 l -0.577 0.364 l -0.649 0.23 -0.759 0.121 -0.893 0.047 c -1.022 -0.029 -1.169 -0.07 -1.32 -0.072 c -1.595 -0.095 -1.866 0.002 -2.064 0.194 c -2.234 0.413 -2.316 0.687 -2.295 0.964 c -2.295 2.608 l -1.719 2.608 l -1.719 1.014 l -1.735 0.843 -1.689 0.67 -1.588 0.531 c -1.492 0.433 -1.357 0.382 -1.219 0.39 c -1.116 0.387 -1.012 0.406 -0.917 0.446 c -0.84 0.479 -0.772 0.531 -0.72 0.595 c -0.667 0.661 -0.63 0.738 -0.611 0.82 c -0.588 0.911 -0.577 1.003 -0.577 1.097 c -0.577 2.611 l 0 2.611 l 0 0 l f Q q 1 0 0 1 409.6413 732.5762 cm 0 0 m 0.545 0 l 0.545 -0.353 l 0.617 -0.209 0.736 -0.094 0.882 -0.026 c 1.03 0.04 1.19 0.073 1.352 0.072 c 1.535 0.075 1.717 0.038 1.883 -0.037 c 2.031 -0.106 2.161 -0.208 2.263 -0.334 c 2.366 -0.465 2.442 -0.615 2.489 -0.775 c 2.54 -0.948 2.566 -1.127 2.566 -1.307 c 2.566 -1.479 2.542 -1.651 2.497 -1.817 c 2.455 -1.973 2.385 -2.121 2.29 -2.252 c 2.099 -2.522 1.789 -2.682 1.458 -2.68 c 1.369 -2.681 1.28 -2.674 1.193 -2.659 c 1.11 -2.644 1.028 -2.618 0.951 -2.584 c 0.875 -2.552 0.802 -2.509 0.736 -2.457 c 0.671 -2.406 0.615 -2.343 0.571 -2.273 c 0.571 -3.575 l -0.005 -3.575 l -0.005 0 l 0 0 l 2.008 -1.307 m 2.008 -1.191 1.993 -1.076 1.963 -0.964 c 1.936 -0.859 1.89 -0.759 1.828 -0.669 c 1.768 -0.584 1.69 -0.514 1.599 -0.462 c 1.503 -0.409 1.395 -0.382 1.286 -0.385 c 1.072 -0.372 0.867 -0.467 0.738 -0.638 c 0.607 -0.836 0.543 -1.072 0.555 -1.31 c 0.554 -1.433 0.57 -1.557 0.603 -1.676 c 0.631 -1.781 0.68 -1.879 0.747 -1.965 c 0.809 -2.044 0.886 -2.109 0.975 -2.157 c 1.071 -2.206 1.178 -2.23 1.286 -2.229 c 1.401 -2.232 1.517 -2.205 1.618 -2.148 c 1.708 -2.096 1.785 -2.025 1.843 -1.939 c 1.903 -1.85 1.945 -1.751 1.968 -1.646 c 1.995 -1.535 2.008 -1.421 2.008 -1.307 c f Q q 1 0 0 1 415.1662 729.9683 cm 0 0 m -0.545 0 l -0.545 0.353 l -0.616 0.211 -0.734 0.099 -0.879 0.034 c -1.027 -0.031 -1.187 -0.065 -1.349 -0.064 c -1.532 -0.067 -1.714 -0.03 -1.88 0.045 c -2.028 0.113 -2.158 0.214 -2.26 0.34 c -2.364 0.47 -2.441 0.62 -2.486 0.781 c -2.538 0.958 -2.564 1.143 -2.563 1.328 c -2.568 1.536 -2.536 1.742 -2.468 1.938 c -2.41 2.097 -2.319 2.242 -2.202 2.364 c -2.101 2.471 -1.977 2.555 -1.838 2.608 c -1.705 2.659 -1.563 2.685 -1.421 2.685 c -1.338 2.685 -1.256 2.678 -1.174 2.664 c -1.091 2.648 -1.01 2.624 -0.932 2.589 c -0.855 2.556 -0.783 2.514 -0.717 2.462 c -0.652 2.411 -0.597 2.349 -0.553 2.279 c -0.553 3.606 l 0.024 3.606 l 0.024 0 l 0 0 l -2.008 1.277 m -2.009 1.166 -1.994 1.056 -1.965 0.948 c -1.939 0.845 -1.896 0.748 -1.835 0.661 c -1.777 0.578 -1.699 0.508 -1.61 0.459 c -1.404 0.355 -1.162 0.355 -0.956 0.459 c -0.866 0.512 -0.789 0.585 -0.73 0.671 c -0.671 0.762 -0.626 0.862 -0.6 0.966 c -0.572 1.076 -0.558 1.188 -0.558 1.301 c -0.543 1.542 -0.612 1.781 -0.751 1.979 c -0.88 2.14 -1.078 2.229 -1.283 2.22 c -1.402 2.224 -1.52 2.196 -1.623 2.138 c -1.714 2.083 -1.793 2.009 -1.852 1.92 c -1.911 1.828 -1.954 1.725 -1.977 1.617 c -1.999 1.505 -2.01 1.392 -2.008 1.277 c f Q q 1 0 0 1 417.9787 730.5499 cm 0 0 m -0.004 -0.052 0.005 -0.104 0.026 -0.151 c 0.052 -0.185 0.094 -0.202 0.136 -0.197 c 0.197 -0.197 l 0.223 -0.2 0.25 -0.2 0.276 -0.197 c 0.276 -0.595 l 0.199 -0.619 l 0.101 -0.64 l 0 -0.656 l -0.085 -0.656 l -0.187 -0.66 -0.288 -0.635 -0.377 -0.584 c -0.461 -0.528 -0.516 -0.437 -0.528 -0.337 c -0.648 -0.451 -0.792 -0.534 -0.951 -0.579 c -1.106 -0.628 -1.269 -0.654 -1.432 -0.656 c -1.546 -0.657 -1.659 -0.641 -1.769 -0.608 c -1.872 -0.579 -1.967 -0.531 -2.053 -0.468 c -2.136 -0.405 -2.203 -0.324 -2.25 -0.231 c -2.3 -0.127 -2.326 -0.012 -2.324 0.104 c -2.33 0.24 -2.299 0.375 -2.236 0.497 c -2.181 0.594 -2.101 0.675 -2.005 0.733 c -1.905 0.791 -1.795 0.833 -1.681 0.855 c -1.562 0.88 -1.442 0.899 -1.32 0.914 c -1.222 0.933 -1.123 0.947 -1.022 0.956 c -0.938 0.963 -0.855 0.977 -0.773 0.999 c -0.708 1.014 -0.649 1.046 -0.6 1.092 c -0.556 1.144 -0.533 1.211 -0.536 1.28 c -0.534 1.344 -0.553 1.408 -0.59 1.46 c -0.624 1.507 -0.668 1.544 -0.72 1.569 c -0.775 1.596 -0.834 1.613 -0.895 1.62 c -0.955 1.624 -1.016 1.624 -1.076 1.62 c -1.215 1.625 -1.354 1.591 -1.474 1.519 c -1.581 1.45 -1.647 1.333 -1.652 1.206 c -2.231 1.206 l -2.227 1.354 -2.185 1.498 -2.108 1.625 c -2.041 1.733 -1.951 1.824 -1.843 1.891 c -1.729 1.96 -1.603 2.007 -1.472 2.032 c -1.329 2.072 -1.183 2.098 -1.036 2.109 c -0.908 2.109 -0.781 2.096 -0.656 2.069 c -0.538 2.044 -0.425 2 -0.321 1.939 c -0.225 1.88 -0.143 1.8 -0.083 1.705 c -0.02 1.599 0.012 1.478 0.008 1.354 c 0.008 0.013 l 0 0 l -0.576 0.728 m -0.674 0.667 -0.785 0.631 -0.9 0.624 c -1.028 0.612 -1.155 0.594 -1.283 0.571 c -1.343 0.561 -1.402 0.547 -1.46 0.528 c -1.515 0.511 -1.566 0.485 -1.612 0.451 c -1.657 0.419 -1.692 0.376 -1.716 0.327 c -1.742 0.267 -1.755 0.203 -1.753 0.138 c -1.755 0.079 -1.735 0.021 -1.697 -0.024 c -1.661 -0.067 -1.615 -0.103 -1.564 -0.127 c -1.509 -0.154 -1.451 -0.171 -1.392 -0.181 c -1.335 -0.19 -1.278 -0.196 -1.222 -0.197 c -1.152 -0.196 -1.083 -0.188 -1.015 -0.173 c -0.94 -0.156 -0.87 -0.127 -0.805 -0.088 c -0.74 -0.048 -0.684 0.004 -0.64 0.066 c -0.594 0.134 -0.571 0.215 -0.574 0.297 c -0.574 0.725 l h f Q q 1 0 0 1 418.3371 732.5762 cm 0 0 m 0.434 0 l 0.434 0.784 l 0.996 0.784 l 0.996 0 l 1.527 0 l 1.527 -0.43 l 0.996 -0.43 l 0.996 -1.822 l 0.993 -1.874 0.993 -1.927 0.996 -1.979 c 1 -2.018 1.011 -2.056 1.031 -2.09 c 1.05 -2.122 1.079 -2.146 1.113 -2.159 c 1.162 -2.177 1.213 -2.185 1.265 -2.183 c 1.387 -2.183 l 1.428 -2.181 1.469 -2.175 1.509 -2.165 c 1.509 -2.608 l 1.323 -2.629 l 1.261 -2.633 1.199 -2.633 1.137 -2.629 c 1.013 -2.633 0.89 -2.619 0.771 -2.587 c 0.688 -2.564 0.613 -2.52 0.553 -2.459 c 0.499 -2.4 0.462 -2.328 0.446 -2.25 c 0.427 -2.155 0.416 -2.059 0.415 -1.963 c 0.415 -0.428 l -0.019 -0.428 l -0.019 0 l 0 0 l f Q q 1 0 0 1 420.7277 731.1235 cm 0 0 m 0 -0.099 0.014 -0.198 0.042 -0.292 c 0.068 -0.382 0.112 -0.466 0.17 -0.54 c 0.229 -0.611 0.303 -0.669 0.388 -0.709 c 0.486 -0.754 0.593 -0.776 0.701 -0.773 c 0.845 -0.78 0.987 -0.742 1.107 -0.664 c 1.216 -0.582 1.296 -0.468 1.336 -0.337 c 1.88 -0.337 l 1.827 -0.603 1.674 -0.838 1.456 -0.996 c 1.349 -1.073 1.231 -1.131 1.105 -1.169 c 0.973 -1.208 0.836 -1.228 0.699 -1.227 c 0.512 -1.23 0.327 -1.196 0.154 -1.126 c 0.003 -1.066 -0.133 -0.973 -0.244 -0.855 c -0.356 -0.73 -0.44 -0.583 -0.491 -0.422 c -0.548 -0.243 -0.576 -0.056 -0.574 0.133 c -0.575 0.313 -0.546 0.493 -0.486 0.664 c -0.426 0.826 -0.336 0.974 -0.221 1.102 c 0.002 1.374 0.334 1.532 0.685 1.535 c 0.877 1.539 1.067 1.495 1.238 1.408 c 1.396 1.326 1.535 1.209 1.644 1.067 c 1.753 0.922 1.833 0.757 1.878 0.582 c 1.927 0.396 1.939 0.203 1.915 0.013 c -0.002 0.013 l 0 0 l 1.341 0.377 m 1.335 0.468 1.315 0.557 1.283 0.643 c 1.253 0.724 1.209 0.798 1.153 0.863 c 1.096 0.926 1.027 0.978 0.951 1.014 c 0.868 1.054 0.777 1.074 0.685 1.073 c 0.594 1.073 0.504 1.055 0.419 1.02 c 0.339 0.986 0.267 0.937 0.207 0.874 c 0.147 0.81 0.099 0.735 0.066 0.653 c 0.031 0.569 0.011 0.479 0.008 0.388 c 1.349 0.388 l h f Q q 1 0 0 1 423.5192 730.7994 cm 0 0 m 0.002 -0.142 0.073 -0.274 0.191 -0.353 c 0.312 -0.423 0.45 -0.458 0.59 -0.454 c 0.651 -0.458 0.711 -0.458 0.773 -0.454 c 0.839 -0.447 0.904 -0.43 0.967 -0.406 c 1.024 -0.385 1.075 -0.349 1.116 -0.303 c 1.155 -0.252 1.174 -0.189 1.168 -0.125 c 1.166 -0.057 1.138 0.008 1.089 0.056 c 1.033 0.107 0.967 0.146 0.895 0.17 c 0.809 0.201 0.72 0.226 0.629 0.245 c 0.329 0.33 l 0.224 0.352 0.121 0.38 0.019 0.415 c -0.076 0.446 -0.166 0.491 -0.247 0.55 c -0.327 0.608 -0.391 0.683 -0.436 0.771 c -0.486 0.873 -0.511 0.986 -0.507 1.1 c -0.512 1.226 -0.475 1.351 -0.404 1.456 c -0.333 1.551 -0.243 1.63 -0.138 1.687 c -0.028 1.747 0.092 1.788 0.215 1.809 c 0.337 1.832 0.462 1.843 0.587 1.843 c 0.716 1.844 0.845 1.83 0.972 1.801 c 1.09 1.774 1.202 1.727 1.304 1.663 c 1.404 1.598 1.488 1.513 1.551 1.413 c 1.621 1.3 1.663 1.173 1.676 1.041 c 1.076 1.041 l 1.059 1.155 0.989 1.253 0.887 1.307 c 0.78 1.355 0.665 1.38 0.547 1.378 c 0.5 1.381 0.452 1.381 0.403 1.378 c 0.35 1.373 0.298 1.36 0.247 1.341 c 0.2 1.325 0.157 1.297 0.122 1.262 c 0.087 1.224 0.069 1.174 0.071 1.124 c 0.069 1.058 0.096 0.995 0.146 0.951 c 0.202 0.903 0.267 0.866 0.337 0.842 c 0.424 0.811 0.512 0.786 0.603 0.768 c 0.917 0.701 l 1.021 0.678 1.124 0.65 1.224 0.616 c 1.319 0.584 1.409 0.539 1.49 0.481 c 1.662 0.359 1.762 0.16 1.755 -0.05 c 1.76 -0.189 1.723 -0.326 1.649 -0.443 c 1.582 -0.551 1.491 -0.642 1.384 -0.709 c 1.267 -0.778 1.14 -0.827 1.007 -0.855 c 0.873 -0.885 0.735 -0.9 0.598 -0.9 c 0.443 -0.902 0.29 -0.883 0.141 -0.845 c 0.01 -0.812 -0.114 -0.753 -0.223 -0.674 c -0.324 -0.601 -0.407 -0.504 -0.465 -0.393 c -0.527 -0.269 -0.559 -0.131 -0.558 0.008 c 0.019 0.008 l 0 0 l f Q 0.146 0.941 0.992 0.044 k q 1 0 0 1 372.9062 729.3892 cm 0 0 m 3.612 2.406 l 3.612 5.296 l 0 5.296 l h f Q 0 0.889 0.676 0 k q 1 0 0 1 376.5186 729.3892 cm 0 0 m -3.612 2.406 l -3.612 5.296 l 0 5.296 l h f Q 0.694 0.076 0.209 0 k q 1 0 0 1 374.7125 735.3145 cm 0 0 m -2.2 0 -3.984 -1.784 -3.984 -3.984 c -3.984 -6.184 -2.2 -7.968 0 -7.968 c 2.2 -7.968 3.984 -6.184 3.984 -3.984 c 3.984 -1.784 2.2 0 0 0 c 0 -6.993 m -1.662 -6.993 -3.009 -5.646 -3.009 -3.984 c -3.009 -2.322 -1.662 -0.975 0 -0.975 c 1.662 -0.975 3.009 -2.322 3.009 -3.984 c 3.009 -5.646 1.662 -6.993 0 -6.993 c f Q 0 0.235 0.86 0 k q 1 0 0 1 376.9137 729.2803 cm 0 0 m -1.118 -1.208 -3.015 -1.281 -4.237 -0.159 c -5.159 0.688 -5.459 2.005 -4.999 3.156 c -5.833 3.687 l -6.736 1.681 -5.843 -0.679 -3.836 -1.582 c -2.218 -2.311 -0.312 -1.881 0.836 -0.528 c 0 0 l f Q 0 0 0 0.6 k q 1 0 0 1 369.1348 736.8087 cm 0 0 m -0.238 0 -0.432 -0.193 -0.432 -0.432 c -0.432 -10.524 l -0.432 -10.763 -0.238 -10.956 0 -10.956 c 57.901 -10.956 l 58.139 -10.956 58.333 -10.763 58.333 -10.524 c 58.333 -0.432 l 58.333 -0.193 58.139 0 57.901 0 c h 57.901 -11.155 m 0 -11.155 l -0.348 -11.155 -0.631 -10.872 -0.631 -10.524 c -0.631 -0.432 l -0.631 -0.084 -0.348 0.199 0 0.199 c 57.901 0.199 l 58.249 0.199 58.532 -0.084 58.532 -0.432 c 58.532 -10.524 l 58.532 -10.872 58.249 -11.155 57.901 -11.155 c f Q EMC Q endstream endobj 1946 0 obj <> endobj 1949 0 obj <>stream Adobe Illustrator CS6 (Windows) 2021-04-12T11:45:36+05:00 2021-06-02T10:28:09+05:00 2021-06-02T10:28:09+05:00 1 False False 20.868494 3.999928 Millimeters Cyan Magenta Yellow Black Default Swatch Group 0 C=0 M=24 Y=86 K=0 PROCESS 100.000000 CMYK 0.000000 23.504999 86.022697 0.000000 C=69 M=8 Y=21 K=0 PROCESS 100.000000 CMYK 69.369003 7.635600 20.892700 0.000000 C=0 M=89 Y=68 K=0 PROCESS 100.000000 CMYK 0.000000 88.946404 67.623398 0.000000 C=15 M=94 Y=99 K=4 PROCESS 100.000000 CMYK 14.578501 94.070297 99.160698 4.416000 C=0 M=0 Y=0 K=84 PROCESS 100.000000 CMYK 0.000000 0.000000 0.000000 84.000000 C=0 M=0 Y=0 K=35 PROCESS 100.000000 CMYK 0.000000 0.000000 0.000000 35.000000 C=0 M=0 Y=0 K=60 PROCESS 100.000000 CMYK 0.000000 0.000000 0.000000 60.000004 Document application/pdf proof:pdf xmp.did:804244B35A9BEB118A6FC3C256996E2F uuid:08e30110-bdb7-4606-97ca-63fb62cbcecc uuid:21079f76-f6d7-4329-b725-f2fb35af5114 uuid:722f8893-0b3c-4402-87fb-c713f1fa0e26 uuid:21079f76-f6d7-4329-b725-f2fb35af5114 uuid:21079f76-f6d7-4329-b725-f2fb35af5114 proof:pdf saved xmp.iid:804244B35A9BEB118A6FC3C256996E2F 2021-04-12T11:45:42+05:00 Adobe Illustrator CS6 (Windows) / endstream endobj 1948 0 obj <>/Border[0 0 0]/H/N/Rect[366.504 739.008 429.659 723.67]/Subtype/Link/Type/Annot>> endobj 1950 0 obj <> endobj 1942 0 obj [1951 0 R 1952 0 R 1953 0 R 1954 0 R 1955 0 R 1956 0 R 1957 0 R 1958 0 R 1959 0 R 1960 0 R 1961 0 R 1962 0 R 1963 0 R] endobj 1943 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 0 0 0 1 k /GS1 gs /T1_0 1 Tf 8 0 0 8 70.8661 731.2159 Tm [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td [(10.1016/j.semr)-32.9(ad)-16(onc.2016.02.006)]TJ 0 0 0 1 k /GS1 gs 0.326 Tw -1.847 -1.25 Td (14.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(T)40(a)15(t)15(ar)-24(yn)]TJ /Span<>> BDC ( )Tj EMC [(B, Kr)-24(yzhani)-15.9(vsk)-17(a)]TJ /Span<>> BDC ( )Tj EMC [(A, Dy)22(ak)-15.9(i)-16(v)]TJ /Span<>> BDC ( )Tj EMC [(I, Andr)-36.9(i)-16(i)-16(v)]TJ /Span<>> BDC ( )Tj EMC [(A. Sur)-32(v)-16(i)-16(v)-15(al of )]TJ 0.102 Tw 27.259 1.25 Td [(p)32(a)15(t)-32(ients wi)-24(t)-13(h r)-23.9(ec)-16(t)15(al cancer. )]TJ /T1_1 1 Tf (Wiad Lek)Tj /T1_0 1 Tf (. 2021;74\(9 cz 1\):2044\2262051. )Tj 0.023 Tw 0 -1.25 TD (PMID: 34725274.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 70.936 688.2959 Tm (REFERENCES)Tj 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0 Tc 0.073 Tw 8 0 0 8 70.8661 675.4612 Tm (1.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(S)-16(k)-16(ipenko)]TJ /Span<>> BDC ( )Tj EMC [(O.G., S)-15.9(hel)35(ygin Y.A., A)-25(chk)-17(asov)]TJ /Span<>> BDC ( )Tj EMC [(S.I. Me)-11.9(t)15(ast)15(a)15(t)-32(ic col)30(or)-24(ec)-15.9(t)15(al )]TJ 0.023 Tw -1.296 -1.25 Td (cancer. M., 2020. 424)Tj /Span<>> BDC ( )Tj EMC (c. \(in Russ.\).)Tj 0.236 Tw T* (2.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Sar)-33(ah)]TJ /Span<>> BDC ( )Tj EMC [(B, S)15(tr)-37(ingf)-28(ield)]TJ /Span<>> BDC ( )Tj EMC (SB, Fleshman)Tj /Span<>> BDC ( )Tj EMC [(JW. Spec)-24(ial)-31(iza)15.1(t)-32(ion im)10(p)25(r)-32(oves )]TJ 0.279 Tw -1.296 -1.25 Td [(outcomes in r)-23.9(ec)-16(t)15(al cancer sur)-31.9(ger)-24(y. )]TJ /T1_1 1 Tf (Surg Oncol)Tj /T1_0 1 Tf (. 2021;37:101568. )Tj 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td [(10.1016/j.sur)-31.9(onc.2021.101568)]TJ 0 0 0 1 k /GS1 gs 0.111 Tw -1.847 -1.25 Td (3.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(V)25(an Cutsem)]TJ /Span<>> BDC ( )Tj EMC [(E, N)-14(or)-24(dl)-30.9(inger)]TJ /Span<>> BDC ( )Tj EMC [(B, A)15(d)42(am)]TJ /Span<>> BDC ( )Tj EMC [(R, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. T)45(o)-14(w)-12(ar)-24(ds a p)31.9(an-Eur)-31.9(o)]TJ 0 Tw (-)Tj 0.149 Tw -1.296 -1.25 Td [(pean consensus on t)-13(he tr)-24(ea)15(tment of p)32(a)15(t)-32(ients wi)-24(t)-13(h col)30(or)-24(ec)-16(t)15.1(al l)-31(i)-16(ver )]TJ 0 Tw T* [(me)-12(t)15(ast)15.1(ases. )]TJ /T1_1 1 Tf 0.137 Tw 5.099 0 Td [(Eur )0.5(J )0.5(Cancer)]TJ /T1_0 1 Tf [(. )0.5(2006;42\(14\):2212\2262221. )0.5(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw 18.224 0 Td (10.1016/j.)Tj -23.324 -1.25 Td (ejca.2006.04.012)Tj 0 0 0 1 k /GS1 gs 0.085 Tw T* (4.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(A)15(d)42(am)]TJ /Span<>> BDC ( )Tj EMC [(R, de G)20.1(r)-33(amont)]TJ /Span<>> BDC ( )Tj EMC [(A, F)-19(iguer)-32.9(as)]TJ /Span<>> BDC ( )Tj EMC [(J, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. of t)-12.9(he EGOSLIM \(E)35(xper)-21.9(t )]TJ 0.29 Tw -1.296 -1.25 Td [(G)20(r)-32(oup on OncoSur)-32(ger)-23.9(y mana)-17(gement of LIver Me)-12(t)15(ast)15(ases\) gr)-32(oup. )]TJ 0.213 Tw T* [(Mana)-17(ging synchr)-32(onous l)-31(i)-16(ver me)-12(t)15.1(ast)15(ases fr)-31.9(om col)30(or)-24(ec)-16(t)15(al cancer: a )]TJ 0.25 Tw T* [(mul)56(t)-32(idisc)-23.9(ipl)-31(inar)-24(y inter)-15(na)15(t)-32(ional consensus. )]TJ /T1_1 1 Tf [(Cancer T)56(reat R)21(ev)]TJ /T1_0 1 Tf (. 2015 )Tj 0.023 Tw T* [(N)-14(ov;41\(9\):729\22641. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw [(10.1016/j.c)-15.9(tr)-32(v.2015.06.006)]TJ 0 0 0 1 k /GS1 gs 0.155 Tw T* (5.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Ki)-24(t)]TJ /Span<>> BDC ( )Tj EMC [(O.I., Gevor)-24(k)-32(y)22(an Y)35(u.A., S)-16(old)42(a)15(tk)-16(ina)]TJ /Span<>> BDC ( )Tj EMC [(N.V., e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. F)10(r)-24(equency and )]TJ 0.201 Tw -1.296 -1.25 Td [(spec)-16(tr)-21.9(um )0.5(of )0.5(KRA)35(S )0.5(gene )0.5(mut)15(a)15(t)-32(ions )0.5(in )0.5(ad)-17(v)-15(anced )0.5(col)30(or)-23.9(ec)-16(t)15(al )0.5(cancer. )]TJ /T1_1 1 Tf 0.116 Tw T* [(Clinical and mor)-18(phological features. Molecular Medicine)]TJ /T1_0 1 Tf (. 2015;5:26\226)Tj 0.238 Tw T* [(29. A)15(v)-15(ail)-15.9(able b)12(y ht)-30(tps://molmed)17(jour)-14.9(nal.r)-22(u/r)-21.9(u/24999490-2015-05-)]TJ 0.023 Tw T* [(05 \(a)-17(ccessed: 20.01.2023\). \(in Russ.\).)]TJ 0.35 Tw T* (6.)Tj /Span<>> BDC ( )Tj EMC 1.297 0 Td [(V)28.6(od)-16.4(ol)-16.4(a)-24.4(zhsk)-32.4(y)]TJ /Span<>> BDC ( )Tj EMC [(D.I., Ant)16.7(one)-12.4(ts)]TJ /Span<>> BDC ( )Tj EMC [(A.V., Dv)-15.4(adnenko)]TJ /Span<>> BDC ( )Tj EMC [(K.V., e)-12.4(t)]TJ /Span<>> BDC ( )Tj EMC [(al. T)46.7(he )]TJ 0.193 Tw -1.297 -1.25 Td [(r)-24(el)-16(a)15.1(t)-32(ionship of KRA)35(S gene mut)15(a)15(t)-31.9(ions wi)-24(t)-13(h cl)-31(inical and p)32(a)15(t)-13(hol)30(o)-16(gi)]TJ 0 Tw (-)Tj 0.088 Tw T* [(cal )0.5(fea)15(tur)-24(es )0.5(of )0.6(col)30(or)-24(ec)-16(t)15(al )0.6(cancer )0.5(in )0.6(p)32(a)15(t)-32(ients )0.5(in )0.6(t)-13(he )0.5(sout)-12.9(h )0.5(of )0.5(Russia. )]TJ /T1_1 1 Tf 0.212 Tw T* [(Inter)-14(national Jour)-13.9(nal of Exper)-37(imental Education)]TJ /T1_0 1 Tf (. 2014;1-1: 65-68. )Tj -0.035 Tw T* [(A)15(v)-15(ail)-15.9(able b)12(y ht)-29.9(tps://e)-18(xpeduca)15(t)-31.9(ion.r)-22(u/r)-22(u/ar)-21.9(t)-32(icle/v)-15.9(iew?id=4517 \(d)42(a)15(te )]TJ 0.023 Tw T* [(of addr)-24(ess: 20.01.2023\). \(in Russ.\).)]TJ 0.016 Tw T* (7.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Ki)-24(t)]TJ /Span<>> BDC ( )Tj EMC [(O.I., Gevor)-23.9(k)-32(y)22(an Y)35(u.A., S)-16(old)42(a)15(tk)-15.9(ina)]TJ /Span<>> BDC ( )Tj EMC [(N.V., e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. R)13(esul)56(ts of r)-24(epea)15(t)]TJ 0 Tw (-)Tj 0.073 Tw -1.296 -1.25 Td [(ed l)-30.9(i)-16(ver r)-24(esec)-16(t)-32(ions in me)-12(t)15.1(ast)15(a)15(t)-32(ic col)30(or)-23.9(ec)-16(t)15(al cancer. )]TJ /T1_1 1 Tf [(Surg)12(er)-42.9(y. Jour)-13.9(nal )]TJ 0.093 Tw 29.055 32.5 Td [(named af)-46(ter N.I. Pirogov)]TJ /T1_0 1 Tf [(. 2022;8:45\22652. \(in Russ.\). d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.17116/)Tj T* [(hir)-22(ur)-31.9(gia202208145)]TJ 0 0 0 1 k /GS1 gs 0.062 Tw T* (8.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (Ahmad)Tj /Span<>> BDC ( )Tj EMC [(NZ, A)-14(bbas)]TJ /Span<>> BDC ( )Tj EMC (MH, Khan)Tj /Span<>> BDC ( )Tj EMC [(SU, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC (al. \202)Tj /Span<>> BDC ( )Tj EMC [(me)-12(t)15(a-anal)35(y)-12.9(sis of t)-13(he r)-32(ole )]TJ -0.027 Tw -1.296 -1.25 Td [(of di)-16(ver)-21.9(t)-32(ing ileost)17.1(omy af)-28(ter r)-24(ec)-16(t)15.1(al cancer sur)-31.9(ger)-24(y. )]TJ /T1_1 1 Tf (Int J Colorectal Dis.)Tj /T1_0 1 Tf 0 Tw ( )Tj 0.023 Tw T* [(2021 Mar;36\(3\):445\226455. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1007/s00384-020-03771-z)Tj 0 0 0 1 k /GS1 gs 0.147 Tw T* (9.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(T)40(ao)]TJ /Span<>> BDC ( )Tj EMC (K, Gao)Tj /Span<>> BDC ( )Tj EMC [(J, W)22(ei)]TJ /Span<>> BDC ( )Tj EMC [(Z, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. R)-24(isk f)16(a)-17(c)-15.9(t)17(or)-10(s for anast)17(omo)17(t)-32(ic leak)-17(a)-17(ge )]TJ 0.132 Tw -1.296 -1.25 Td [(af)-28(ter r)-24(ec)-15.9(t)15(al cancer sur)-32(ger)-24(y. )]TJ /T1_1 1 Tf 0 Tw (Chinese. )Tj /T1_0 1 Tf 0.132 Tw 15.27 0 Td [(2018 Apir)-30(l 25;21\(4\):384\226387. )]TJ 0.023 Tw -15.27 -1.25 Td (PMID: 29682707.)Tj 0.004 Tc 0.35 Tw T* (10.)Tj /Span<>> BDC ( )Tj EMC 1.812 0 Td [(Ki)-24(t)]TJ /Span<>> BDC ( )Tj EMC 1.772 0 Td [(O.I., )0.5(Gevor)-24(k)-32(y)22(an )0.6(Y)34.9(u.A., )0.6(S)-16(old)42(a)14.9(tk)-16(ina)]TJ /Span<>> BDC ( )Tj EMC 14.859 0 Td [(N.V. )0.6(e)-12.1(t)]TJ /Span<>> BDC ( )Tj EMC 3.709 0 Td [(al. )0.6(Har)-24(d)-17(w)-12(ar)-24(e)4( )]TJ 0 Tc 0.331 Tw -22.152 -1.25 Td [(inter)-10(st)-31.9(i)-24(t)-32(ial anast)17(omosis in col)30(or)-24(ec)-16(t)15(al cancer: immedia)15.1(te r)-24(esul)56(ts. )]TJ /T1_1 1 Tf 0.003 Tc -0.003 Tw T* [(K)18(olop)45.9(roktologia)]TJ /T1_0 1 Tf 0.35 Tw [(. )0.5(2016;1:48\22653. )0.5(\(in )0.5(Russ.\). )0.5(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs -0.003 Tw 21.007 0 Td (10.33878/2073-)Tj 0 Tc 0 Tw -21.007 -1.25 Td (7556-2016-0-1-48-53)Tj 0 0 0 1 k /GS1 gs 0.336 Tw T* (11.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(K)25(ope)-12(tz)]TJ /Span<>> BDC ( )Tj EMC (S, Chang)Tj /Span<>> BDC ( )Tj EMC [(GJ, O)-24(ver)-16(man)]TJ /Span<>> BDC ( )Tj EMC [(MJ, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Im)10(p)25(r)-32(oved sur)-32(v)-16(i)-15.9(v)-15(al )]TJ 0.001 Tc 0.349 Tw -1.796 -1.25 Td [(in me)-11.9(t)15.1(ast)15.1(a)15.1(t)-32(ic col)30.1(or)-23.9(ec)-15.9(t)15(al cancer is asso)-16(c)-23.9(ia)15.1(ted wi)-24(t)-12.9(h ad)-16(opt)-31.9(ion of)1( )]TJ 0 Tc 0.319 Tw T* [(hep)32(a)15(t)-32(ic r)-23.9(esec)-16(t)-32(ion and im)10(p)25(r)-32(oved )0.5(chemo)17(t)-13(her)-33(apy. )]TJ /T1_1 1 Tf 20.798 0 Td [(J Clinical )0.5(Oncol.)]TJ /T1_0 1 Tf 0 Tw ( )Tj 0.023 Tw -20.798 -1.25 Td [(2009;27\(22\):3677\22683. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw [(10.1200/JC)13(O.2008.20.5278)]TJ 0 0 0 1 k /GS1 gs 0.341 Tw T* (12.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Dossa)Tj /Span<>> BDC ( )Tj EMC 2.87 0 Td [(F, )0.6(A)-25(cuna)]TJ /Span<>> BDC ( )Tj EMC 4.274 0 Td [(SA, )0.6(R)-24(ickles)]TJ /Span<>> BDC ( )Tj EMC 5.178 0 Td [(A)35(S, )0.6(e)-12(t)]TJ /Span<>> BDC ( )Tj EMC 3.145 0 Td [(al. )0.6(Asso)-16(c)-24(ia)15(t)-32(ion )0.6(Be)-12(t)-32(ween )]TJ 0.04 Tw -17.263 -1.25 Td [(A)15(d)17(juv)-15(ant Chemo)17.1(t)-13(her)-33(apy and O)-24(ver)-32.9(all Sur)-32(v)-16(i)-16(v)-14.9(al in P)40(a)15(t)-31.9(ients W)-16(i)-24(t)-13(h R)13(ec)-16(t)15(al )]TJ 0.007 Tc 0.349 Tw T* [(Cancer and P)40.1(a)15.1(t)-12.8(hol)30.1(o)-15.9(gical Com)10.1(ple)-11.9(te R)13(esponse Af)-27.9(ter Neoad)17.1(juv)-14.9(ant)7( )]TJ 0.35 Tw T* [(Chemo)16.7(t)-13.3(her)-33.3(apy and R)12.6(esec)-16.3(t)-32.3(ion. )]TJ /T1_1 1 Tf [(J)29.7(AMA Oncol.)]TJ /T1_0 1 Tf [( 2018;4\(7\):930\226937.)7.1( )]TJ 0 Tc 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1001/jamaoncol.2017.5597)Tj 0 0 0 1 k /GS1 gs -0.028 Tw -1.847 -1.25 Td (13.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Joye)Tj /Span<>> BDC ( )Tj EMC [(I, Hauster)-15.9(mans)]TJ /Span<>> BDC ( )Tj EMC [(K. Which P)40(a)15(t)-32(ients W)-16(i)-23.9(t)-13(h R)13(ec)-16(t)15(al Cancer Do N)-14(o)17(t )]TJ 0.185 Tw -1.796 -1.25 Td [(Need R)-10(adio)17(t)-13(her)-32.9(apy? )]TJ /T1_1 1 Tf [(Semin R)20(adiat Oncol.)]TJ /T1_0 1 Tf ( 2016 Jul;26\(3\):199\226204. )Tj 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td [(10.1016/j.semr)-32.9(ad)-16(onc.2016.02.006)]TJ 0 0 0 1 k /GS1 gs 0.326 Tw -1.847 -1.25 Td (14.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(T)40(a)15(t)15(ar)-24(yn)]TJ /Span<>> BDC ( )Tj EMC [(B, Kr)-24(yzhani)-15.9(vsk)-17(a)]TJ /Span<>> BDC ( )Tj EMC [(A, Dy)22(ak)-15.9(i)-16(v)]TJ /Span<>> BDC ( )Tj EMC [(I, Andr)-36.9(i)-16(i)-16(v)]TJ /Span<>> BDC ( )Tj EMC [(A. Sur)-32(v)-16(i)-16(v)-15(al of )]TJ 0.102 Tw -1.796 -1.25 Td [(p)32(a)15(t)-32(ients wi)-24(t)-13(h r)-23.9(ec)-16(t)15(al cancer. )]TJ /T1_1 1 Tf (Wiad Lek)Tj /T1_0 1 Tf (. 2021;74\(9 cz 1\):2044\2262051. )Tj 0.023 Tw T* (PMID: 34725274.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0 Tw 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\033\030\031\030\213\b)-20.9(\035\231\213\233\t \021\032)50(\b)42(\032\231\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj -51.938 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 23, \023\0221)69(, 202)69(4)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 23, \023\0221)69(, 202)69(4)]TJ /T1_4 1 Tf 25 0 0 25 28.0776 56.0378 Tm (58)Tj ET endstream endobj 1951 0 obj <>/Border[0 0 0]/H/N/Rect[85.6442 738.512 198.139 729.216]/Subtype/Link/Type/Annot>> endobj 1952 0 obj <>/Border[0 0 0]/H/N/Rect[85.6442 642.757 186.571 633.461]/Subtype/Link/Type/Annot>> endobj 1953 0 obj <>/Border[0 0 0]/H/N/Rect[257.457 612.757 291.968 603.301]/Subtype/Link/Type/Annot>> endobj 1954 0 obj <>/Border[0 0 0]/H/N/Rect[70.8661 602.757 127.138 593.461]/Subtype/Link/Type/Annot>> endobj 1955 0 obj <>/Border[0 0 0]/H/N/Rect[149.662 552.757 240.045 543.461]/Subtype/Link/Type/Annot>> endobj 1956 0 obj <>/Border[0 0 0]/H/N/Rect[490.498 682.757 524.409 673.301]/Subtype/Link/Type/Annot>> endobj 1957 0 obj <>/Border[0 0 0]/H/N/Rect[303.307 672.757 365.243 663.461]/Subtype/Link/Type/Annot>> endobj 1958 0 obj <>/Border[0 0 0]/H/N/Rect[403.337 642.757 500.161 633.461]/Subtype/Link/Type/Annot>> endobj 1959 0 obj <>/Border[0 0 0]/H/N/Rect[471.365 582.757 524.409 573.301]/Subtype/Link/Type/Annot>> endobj 1960 0 obj <>/Border[0 0 0]/H/N/Rect[303.307 572.757 373.387 563.461]/Subtype/Link/Type/Annot>> endobj 1961 0 obj <>/Border[0 0 0]/H/N/Rect[393.727 532.757 482.431 523.461]/Subtype/Link/Type/Annot>> endobj 1962 0 obj <>/Border[0 0 0]/H/N/Rect[318.085 482.757 417.861 473.461]/Subtype/Link/Type/Annot>> endobj 1963 0 obj <>/Border[0 0 0]/H/N/Rect[318.085 452.757 430.58 443.461]/Subtype/Link/Type/Annot>> endobj 1976 0 obj <> endobj 1975 0 obj <> endobj 1974 0 obj <> endobj 1973 0 obj <> endobj 1972 0 obj <> endobj 1971 0 obj <> endobj 1970 0 obj <> endobj 1969 0 obj <> endobj 1968 0 obj <> endobj 1967 0 obj <> endobj 1966 0 obj <> endobj 1965 0 obj <> endobj 1964 0 obj <> endobj 1940 0 obj [1977 0 R 1978 0 R 1979 0 R 1980 0 R 1981 0 R 1982 0 R 1983 0 R 1984 0 R 1985 0 R] endobj 1941 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\033\016\222)21(\215\007\216)21(\026)11(\013\026\020 \002\016\222\016\n\227\220\220 \221\002\205\024\025\203 \n\220\ \n\220 \221\002\220\022\024\016\026)11(\013\006)-10(\026)11(\013\026\220\017\016\006\n)10(\025\024\022\002\013\n\016)]TJ 42.522 0 Td [(Results of r)31(ectal r)31(esection in metastatic cancer)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0.018 Tc -0.018 Tw 10 0 0 10 42.5197 724.8299 Tm [(\221)35.2(\021)-3.5(\026)6.2(\021\017)15.6(\f)-18(\021\017)22.5(\004)9.8(\036)7.6(\f)16.4(\022)-1.1(\026)-3(\016)18( \024)6.2(\002)21(\030)6.6(\026)11.7(\002)8.1(\024)7.1(\021\022)-1.1(\026)21.7(:)]TJ /T1_2 1 Tf -0.005 Tc 0.005 Tw 11.349 0 Td [( \216)7.5(\023)4(\026)-4.1(\030\025\003)5.3(\025\032)-5(\n)4.7(\027)-2.9(\026)]TJ /Span<>> BDC 5.644 0 Td ( )Tj EMC [(\035)20(.)22.5(\223)21.6(.)]TJ /T1_1 1 Tf 0.002 Tc -0.002 Tw -16.993 -1.218 Td [(\203)7.2(\026\023)4.2(\017\f)-10.8(\026)1.7(\027)3.7(\017)-6.7(\036)2.1( \021)-7.9(\036)-3.4(\022\f)-34(\021)-19.5(\026)5.7(:)]TJ /T1_2 1 Tf -0.01 Tc 0.01 Tw 7.694 0 Td [( \207)-3.2(\n\023)-3.8(\030)-5.2(\026)-8.2(\024\013)2.7(\025)-2.8(\021\026)]TJ /Span<>> BDC 5.198 0 Td ( )Tj EMC [(\217)18.8(.)18.5(\216)14.3(.)]TJ /T1_1 1 Tf 0 Tc 0 Tw -12.891 -1.218 Td [(\217)5.5(\036)-19(\007)-20.1(\026\022)-32.6(\021)-17.7(\017)1.5(\030)-11.8(\024)-4.4(\r)-8.8(\026\027)1.8(\017)-8.7(\036)6.5(:)]TJ /T1_2 1 Tf -0.01 Tc 0.01 Tw [( \210)91.4(\031)-3.4(\027)-10.7(\n)-5.1(\032)-4.1(\013)-23.9(\002\021)]TJ /Span<>> BDC 11.006 0 Td ( )Tj EMC [(\223)16.6(.)-2.7(\201)-12.2(.)-2.2(,)-10( \222)5.6(\n\023)-6.7(\031)-11.4(\t)-6(\021\025)-2.3(\013\n\027)]TJ /Span<>> BDC 7.226 0 Td ( )Tj EMC [(\036)12.8(.)19.3(\217)18.9(.)]TJ /T1_3 1 Tf 0 Tc 0.023 Tw -18.232 -2.436 Td (PARTICIPATION OF AUTHORS)Tj /T1_1 1 Tf 0 Tw 0 -1.218 TD [(C)-6.5(o)0.8(nce)-0.7(p)-12.3(t a)2.4(n)-4.6(d d)-5.4(e)-13.3(s)-16.6(i)3.2(g)1.2(n o)-2.2(f t)-16.7(h)-5.3(e s)-19.9(t)-12.8(ud)-10.9(y)-11.8(:)]TJ /T1_2 1 Tf [( O)-7.4(l)4.8(e)-3.5(g)]TJ /Span<>> BDC ( )Tj EMC [(I)2.5(.)]TJ /Span<>> BDC ( )Tj EMC [(K)10.9(i)0.9(t)]TJ /T1_1 1 Tf 1.665 Tw 0 -1.218 TD [(C)-6.5(o)-5.8(l)-19(l)-14.3(e)-9.4(c)-32.5(t)-37.3(i)3.2(o)0.8(n a)2.4(n)-4.6(d p)-3.8(r)-6(o)-6.9(ce)-13.3(s)-12.8(s)-16.6(i)7.1(n)-1.9(g o)-2.2(f m)1.8(a)-8.4(t)-15.2(e)-2.1(r)-48(i)5.1(a)-1.5(l)-22.5(:)]TJ /T1_2 1 Tf 0 Tw ( )Tj 1.038 Tw 0 -1.218 TD [(O)-7.4(l)4.7(ga)]TJ /Span<>> BDC ( )Tj EMC [(K)-13.6(.)]TJ /Span<>> BDC ( )Tj EMC [(B)0.8(on)-0.6(d)1.9(ar)2.4(e)-2.6(n)7.5(k)12.9(o)-3.7(, A)3.6(l)4.8(e)-28.5(x)4.9(a)-0.7(n)-0.6(d)-1(e)-1.7(r)]TJ /Span<>> BDC ( )Tj EMC [(E)19.8(.)]TJ /Span<>> BDC ( )Tj EMC [(A)3.8(n)6.2(i)11(s)-8.3(i)8.4(m)-1.1(o)-0.6(v)33.6(, )]TJ 0 Tw T* [(M)5.2(ar)-35.3(i)8.4(n)4.8(a)]TJ /Span<>> BDC ( )Tj EMC [(A)-12.5(.)]TJ /Span<>> BDC ( )Tj EMC [(G)4.9(us)7.8(ar)2.4(e)-4(v)10.9(a)]TJ /T1_1 1 Tf -0.007 Tc 0.007 Tw T* [(St)-34.7(a)-15.4(t)-44.4(i)-4.3(s)-27(t)-44.4(i)-1.8(c)-18.8(a)-8.5(l)-7( p)-10.8(r)-13(o)-13.9(c)-6.9(e)-20.2(s)-19.8(s)-23.6(in)-8.9(g)2(:)]TJ /T1_2 1 Tf -0.006 Tc 0.006 Tw 9.088 0 Td [( L)18.9(y)-2.2(u)0.5(b)-11.9(o)-6.6(v)]TJ /Span<>> BDC 2.927 0 Td ( )Tj EMC [(Y)51.6(.)]TJ /Span<>> BDC 0.914 0 Td ( )Tj EMC [(V)-5.3(l)-2.7(a)-10.4(d)-4.6(i)2.4(mi)3.4(r)-3.6(o)-6.6(v)4.9(a)]TJ /T1_1 1 Tf -0.007 Tc 0.007 Tw -12.93 -1.218 Td [(W)-3.9(r)-55(i)-13(t)-44.4(in)-8.9(g)-7( t)-22.2(e)-30.9(x)-42.9(t)-27.1(:)]TJ /T1_2 1 Tf 0 Tc 0 Tw 5.27 0 Td [( N)8.7(a)-4.9(t)2.3(al)4.3(i)5.9(a)]TJ /Span<>> BDC ( )Tj EMC [(V)53.1(.)]TJ /Span<>> BDC ( )Tj EMC [(S)5.6(o)-1.1(l)0.5(d)1.9(a)-4.9(t)-6.8(k)-18.5(i)8.4(n)4.8(a)]TJ /T1_1 1 Tf 0.006 Tc -0.006 Tw -5.27 -1.218 Td [(E)11.6(dit)-31.4(i)13.1(n)4.1(g)15(:)]TJ /T1_2 1 Tf 0 Tc 0 Tw 3.238 0 Td [( Y)33.7(u)6.1(r)-35.3(i)]TJ /Span<>> BDC ( )Tj EMC [(A)-12.5(.)]TJ /Span<>> BDC ( )Tj EMC [(G)-1.4(e)-4(v)7.6(o)1.3(r)-2.5(k)-21.7(y)3.8(a)-0.8(n)-6(, E)20.6(v)8.2(g)-2.5(e)-2.6(n)6.2(y)]TJ /Span<>> BDC ( )Tj EMC [(N)13(.)]TJ /Span<>> BDC ( )Tj EMC [(K)13.4(o)-1.1(l)4.8(e)-18(s)9.6(n)6.2(i)7.9(k)12.9(o)-0.6(v)]TJ /T1_3 1 Tf 0.023 Tw -3.238 -2.436 Td (\255\026\036\031\036\025\034\224 \017\225 \032\026\020\017\022\032\221 \(\ ORCID\))Tj /T1_1 1 Tf 0.184 Tw T* (\025\017\021 \210\035\036\020 \222\r\026\027\024\r\017\004)Tj /Span<>> BDC ( )Tj EMC (\227 \007.\n.\027., \023\030\024\235\036\f\f\024\030, \026\022\026\007\036\ \n\017\022 )Tj -0.018 Tw T* (\217\202\203, \206\036\027\036\030\026\035\034\027\t\005 \007\017\030\036\ \022\021\024\030 \205\206\207\211 \253\203\204\222\037 \024\027\022\024\035\ \024\020\017\017\273 )Tj 0.054 Tw T* (\204\017\027\007\030\026\r\026 \217\024\f\f\017\017, \020.)Tj /Span<>> BDC ( )Tj EMC (\217\024\f\021\024\r-\027\026-\212\024\027\031, \217\024\f\f\017\016; OR\ CID )Tj 0 Tw T* [(0000-0003-3061-6108; eL)-31.9(ibr)-33(ar)-24(y SPIN: 1728-0329)]TJ 0.081 Tw T* [(\206\036\r\024\030\022\016\027 \236\030\017\005 )0.5(\202\030\021\031\001\036\r\017\004)]TJ /Span<>> BDC ( )Tj EMC 11.581 0 Td [(\227 \007.\n.\027., )0.5(\023\030\024\235\036\f\f\024\030, \026)]TJ 0 Tw (-)Tj 0.489 Tw -11.581 -1.218 Td (\r\036\007\031\033\013\017\005 \024\021\007\036\035\036\027\017\036\n \026\ \002\007\024\n\017\027\026\035\034\027\024\005 \024\027\022\024\035\024\020\ \017\017 )Tj 0.301 Tw T* (\225 2 \205\206\207\211 \253\203\204\222\037 \024\027\022\024\035\024\020\ \017\017\273 \204\017\027\007\030\026\r\026 \217\024\f\f\017\017, )Tj 0.268 Tw T* (\020.)Tj /Span<>> BDC ( )Tj EMC (\217\024\f\021\024\r-\027\026-\212\024\027\031, \217\024\f\f\017\016; OR\ CID 0000-0003-1957-)Tj 0 Tw T* [(7363; eL)-32(ibr)-32.9(ar)-24(y SPIN: 8643-2348)]TJ 0.446 Tw T* (\221\024\035\007\026\021\022\017\027\026 \203\026\021\026\035\034\016 \200\ \026\f\017\035\034\036\r\027\026)Tj /Span<>> BDC ( )Tj EMC (\227 \007.\n.\027., \r\036\007\031)Tj 0 Tw (-)Tj 0.301 Tw T* (\013\017\005 \027\026\031\004\027\t\005 \f\024\021\030\031\007\027\017\022\ \205\206\207\211 \253\203\204\222\037 \024\027\022\024\035\024\020\017\017\ \273 )Tj 0.054 Tw T* (\204\017\027\007\030\026\r\026 \217\024\f\f\017\017, \020.)Tj /Span<>> BDC ( )Tj EMC (\217\024\f\021\024\r-\027\026-\212\024\027\031, \217\024\f\f\017\016; OR\ CID )Tj 0 Tw T* [(0000-0002-0118-4935; eL)-31.9(ibr)-33(ar)-24(y SPIN: 8392-6679)]TJ 0.392 Tw T* (\025\024\035\036\f\027\017\022\024\r \213\r\020\036\027\017\005 \203\017\ \022\024\035\026\036\r\017\004)Tj /Span<>> BDC ( )Tj EMC (\227 \007.\n.\027., \f\021\026\030)Tj 0 Tw (-)Tj 0.802 Tw T* (\001\017\005 \027\026\031\004\027\t\005 \f\024\021\030\031\007\027\017\022\ , \026\r\036\007\031\033\013\017\005 \024\021\007\036\035\036)Tj 0 Tw (-)Tj 0.57 Tw T* (\027\017\036\n \202\002\007\024\n\017\027\026\035\034\027\024\005 \024\027\ \022\024\035\024\020\017\017 \2251 \f)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\024\005 )Tj 0.088 Tw 23.244 35.316 Td [(\030\036\027\021\020\036\027\220\027\007\024\r\026\f\022\031\035\016\030\ \027\t\b )0.5(\n\036\021\024\007\024\r \007\017\026\020\027\024\f\021\017\022\017 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC (\035\036)Tj 0 Tw (-)Tj 0.188 Tw T* (\004\036\027\017\016 \205\206\207\211 \253\203\204\222\037 \024\027\022\024\ \035\024\020\017\017\273 \204\017\027\007\030\026\r\026 \217\024\f\f\017\ \017, )Tj 0.337 Tw T* (\020.)Tj /Span<>> BDC ( )Tj EMC (\217\024\f\021\024\r-\027\026-\212\024\027\031, \217\024\f\f\017\016; OR\ CID:0000-0001-9749-)Tj 0 Tw T* [(709X; eL)-31.9(ibr)-33(ar)-24(y SPIN: 8434-6494)]TJ 0.082 Tw T* (\206\031\f\026\030\036\r\026 \204\026\030\017\027\026 \202\035\036\022\f\ \026\027\007\030\024\r\027\026)Tj /Span<>> BDC ( )Tj EMC (\227 \022.\n.\027., \026\r\036\007\031\033)Tj 0 Tw (-)Tj -0.064 Tw T* (\013\026\016 \024\021\007\036\035\036\027\017\036\n \030\026\007\017\024\ \035\024\020\017\017 \205\206\207\211 \253\203\204\222\037 \024\027\022\024\ \035\024\020\017\017\273 )Tj 0.054 Tw 0 -1.218 TD (\204\017\027\007\030\026\r\026 \217\024\f\f\017\017, \020.)Tj /Span<>> BDC ( )Tj EMC (\217\024\f\021\024\r-\027\026-\212\024\027\031, \217\024\f\f\017\016; OR\ CID )Tj 0 Tw 0 -1.218 TD [(0000-0002-9426-9662, eL)-31.9(ibr)-33(ar)-24(ySPIN: 9040-5476)]TJ 0.013 Tw T* (\207\024\027\007\026\030\036\027\022\024 \210\035\034\020\026 \025\024\027\ \f\021\026\027\021\017\027\024\r\027\026)Tj /Span<>> BDC ( )Tj EMC (\227 \026\f\023\017\030\026\027\021 \205\206\207\211 )Tj 0.07 Tw T* (\253\203\204\222\037 \024\027\022\024\035\024\020\017\017\273 \204\017\027\ \007\030\026\r\026 \217\024\f\f\017\017, \020.)Tj /Span<>> BDC ( )Tj EMC (\217\024\f\021\024\r-\027\026-)Tj 0 Tw T* (\212\024\027\031, \217\024\f\f\017\016; ORCID 0000-0002-9543-4551)Tj 0.003 Tw T* (\202\027\017\f\017\n\024\r \202\035\036\022\f\026\027\007\030 \213\r\020\ \036\027\034\036\r\017\004)Tj /Span<>> BDC ( )Tj EMC (\227 \r\030\026\004-\024\027\022\024\035\024\020 \024\021)Tj 0 Tw (-)Tj 0.054 Tw 0 -1.218 TD [(\007\036\035\036\027\017\016 )0.6(\026\002\007\024\n\017\027\026\035\034\027\024\005 )0.5(\024\027\022\024\035\024\020\017\017 )0.6(\2251 )0.5(\205\206\207\211 )0.5(\253\203\204\222\037 )]TJ 0.334 Tw 0 -1.218 TD (\024\027\022\024\035\024\020\017\017\273 \204\017\027\007\030\026\r\026\ \217\024\f\f\017\017, \020.)Tj /Span<>> BDC ( )Tj EMC (\217\024\f\021\024\r-\027\026-\212\024\027\031, )Tj 0 Tw 0 -1.218 TD (\217\024\f\f\017\016; ORCID 0000-0003-1891-9528)Tj 0.048 Tw T* (\200\035\026\007\017\n\017\030\024\r\026 \214\033\002\024\r\034 \236\030\ \034\036\r\027\026)Tj /Span<>> BDC ( )Tj EMC (\227 \007.\n.\027., \023\030\024\235\036\f\f\024\030, )Tj 0.261 Tw T* (\030\031\022\024\r\024\007\017\021\036\035\034 \024\021\007\036\035\026 \ \035\036\022\026\030\f\021\r\036\027\027\024\020\024 \035\036\004\036\027\ \017\016 \024\023\031)Tj 0 Tw (-)Tj 0.195 Tw T* [(\b\024\035\036\005 )0.6(\205\206\207\211 )0.5(\253\203\204\222\037 )0.5(\024\027\022\024\035\024\020\017\017\273 )0.5(\204\017\027\007\030\026\r\026 )0.6(\217\024\f\f\017\017, )]TJ 0.268 Tw T* (\020.)Tj /Span<>> BDC ( )Tj EMC (\217\024\f\021\024\r-\027\026-\212\024\027\031, \217\024\f\f\017\016; OR\ CID 0000-0003-4236-)Tj 0 Tw T* [(6476; eL)-32(ibr)-32.9(ar)-24(y SPIN: 4857-6202)]TJ /T1_3 1 Tf 0.023 Tw 0 -2.436 TD (INFORMATION ABOUT THE AUTHORS \(ORCID\))Tj /T1_1 1 Tf 0 Tw 0 -1.218 TD [(Oleg I. Ki)-23.9(t)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0003-3061-6108)Tj T* [(Y)35(ur)-37(i A. Gevor)-23.8(k)-32(y)22(an)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0003-1957-7363)Tj T* [(Na)15(t)15(al)-31(ia V. S)-15.9(old)42(a)15(tk)-16(ina)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0002-0118-4935)Tj T* [(Ev)-21(geny N. K)25.1(olesnikov)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0001-9749-709X)Tj T* [(Mar)-37(ina A. Gusar)-23.8(ev)-15(a)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0002-9426-9662)Tj T* [(Ol)16(ga K. Bond)42.1(ar)-24(enko)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0002-9543-4551)Tj T* [(Ale)-18(x)-10.9(ander E. Anisimov)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0003-1891-9528)Tj T* [(L)70(yubov Y. Vl)-15.9(adimir)-32(ov)-14.9(a)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0003-4236-6476)Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 42.5896 335.1339 Tm [(\r\031\024\034\033)48(\026)45(\024)-10(\223\033)48(\026)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0 Tc 0.219 Tw 8 0 0 8 42.5197 322.2992 Tm (1.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (\221\022\017\023\036\027\022\024)Tj /Span<>> BDC ( )Tj EMC (\210.\206., \234\036\035\t\020\017\027)Tj /Span<>> BDC ( )Tj EMC (\236.\202., \202\004\022\026\f\024\r)Tj /Span<>> BDC ( )Tj EMC (\221.\222. \204\036\021\026\f\021\026\021\017\004\036\f\022\017\005 )Tj 0.023 Tw -1.296 -1.25 Td (\022\024\035\024\030\036\022\021\026\035\034\027\t\005 \030\026\022. \204\ ., 2020. 424 \f.)Tj 0.236 Tw 0 -1.25 TD (2.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Sar)-33(ah)]TJ /Span<>> BDC ( )Tj EMC [(B, S)15(tr)-37(ingf)-28(ield)]TJ /Span<>> BDC ( )Tj EMC (SB, Fleshman)Tj /Span<>> BDC ( )Tj EMC [(JW. Spec)-24(ial)-31(iza)15.1(t)-32(ion im)10(p)25(r)-32(oves )]TJ 0.279 Tw -1.296 -1.25 Td [(outcomes in r)-23.9(ec)-16(t)15(al cancer sur)-31.9(ger)-24(y. )]TJ /T1_2 1 Tf (Surg Oncol)Tj /T1_1 1 Tf (. 2021;37:101568. )Tj 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td [(10.1016/j.sur)-31.9(onc.2021.101568)]TJ 0 0 0 1 k /GS1 gs 0.111 Tw -1.847 -1.25 Td (3.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(V)25(an Cutsem)]TJ /Span<>> BDC ( )Tj EMC [(E, N)-14(or)-24(dl)-30.9(inger)]TJ /Span<>> BDC ( )Tj EMC [(B, A)15(d)42(am)]TJ /Span<>> BDC ( )Tj EMC [(R, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. T)45(o)-14(w)-12(ar)-24(ds a p)31.9(an-Eur)-31.9(o)]TJ 0 Tw (-)Tj 0.149 Tw -1.296 -1.25 Td [(pean consensus on t)-13(he tr)-24(ea)15(tment of p)32(a)15(t)-32(ients wi)-24(t)-13(h col)30(or)-24(ec)-16(t)15.1(al l)-31(i)-16(ver )]TJ 0 Tw T* [(me)-12(t)15(ast)15.1(ases. )]TJ /T1_2 1 Tf 0.137 Tw 5.099 0 Td [(Eur )0.5(J )0.5(Cancer)]TJ /T1_1 1 Tf [(. )0.5(2006;42\(14\):2212\2262221. )0.5(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw 18.224 0 Td (10.1016/j.)Tj -23.324 -1.25 Td (ejca.2006.04.012)Tj 0 0 0 1 k /GS1 gs 0.085 Tw T* (4.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(A)15(d)42(am)]TJ /Span<>> BDC ( )Tj EMC [(R, de G)20.1(r)-33(amont)]TJ /Span<>> BDC ( )Tj EMC [(A, F)-19(iguer)-32.9(as)]TJ /Span<>> BDC ( )Tj EMC [(J, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. of t)-12.9(he EGOSLIM \(E)35(xper)-21.9(t )]TJ 0.29 Tw -1.296 -1.25 Td [(G)20(r)-32(oup on OncoSur)-31.9(ger)-24(y mana)-17(gement of LIver Me)-12(t)15(ast)15(ases\) gr)-32(oup. )]TJ 0.213 Tw T* [(Mana)-17(ging synchr)-32(onous l)-31(i)-16(ver me)-12(t)15.1(ast)15(ases fr)-31.9(om col)30(or)-24(ec)-16(t)15(al cancer: a )]TJ 0.25 Tw T* [(mul)56(t)-32(idisc)-23.9(ipl)-31(inar)-24(y inter)-15(na)15(t)-32(ional consensus. )]TJ /T1_2 1 Tf [(Cancer T)56(reat R)21(ev)]TJ /T1_1 1 Tf (. 2015 )Tj 0.023 Tw T* [(N)-14(ov;41\(9\):729\22641. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw [(10.1016/j.c)-15.9(tr)-32(v.2015.06.006)]TJ 0 0 0 1 k /GS1 gs 0.272 Tw T* (5.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (\025\017\021)Tj /Span<>> BDC ( )Tj EMC (\210.\222., \206\036\r\024\030\022\016\027)Tj /Span<>> BDC ( )Tj EMC (\236.\202., \221\024\035\007\026\021\022\017\027\026)Tj /Span<>> BDC ( )Tj EMC (\203.\200., \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. \223\026\f\021\024\021\026 )Tj 0.114 Tw -1.296 -1.25 Td (\017)Tj /Span<>> BDC ( )Tj EMC (\f\023\036\022\021\030 \n\031\021\026\006\017\005 \020\036\027\026 )Tj /T1_2 1 Tf 0 Tw [(KRA)50(S)]TJ /T1_1 1 Tf 0.114 Tw ( \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\030\026\f\023\030\024\f\021\030\026\027\036\027\027\024\n \022\024\035\024\ \030\036\022\021\026\035\034)Tj 0 Tw (-)Tj 0.059 Tw T* (\027\024\n \030\026\022\036. \025\035\017\027\017\022\024-\n\024\030\235\ \024\035\024\020\017\004\036\f\022\017\036 \024\f\024\002\036\027\027\024\ \f\021\017. )Tj /T1_2 1 Tf 0 Tw (\240\n\023\031\013\205\023\002\032\021\026\002 )Tj T* (\003\031\030\025\203\025\021\026. )Tj /T1_1 1 Tf 0.161 Tw 4.687 0 Td (2015;5:26\22629. \212\024\f\021\031\023\027\024 \023\024)Tj /Span<>> BDC ( )Tj EMC [(ht)-30(tps://molmed)17.1(jour)-15(nal.r)-22(u/)]TJ 0.023 Tw -4.687 -1.25 Td [(r)-22(u/24999490-2015-05-05 \(\007\026\021\026 \024\002\030\026\013\036\027\017\ \016: 20.01.2023\).)]TJ -0.013 Tw T* (6.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (\200\024\007\024\035\026\032\f\022\017\005)Tj /Span<>> BDC ( )Tj EMC 5.79 0 Td [(\212.\222., )0.5(\202\027\021\024\027\036\006)]TJ /Span<>> BDC ( )Tj EMC 5.869 0 Td [(\202.\200., )0.5(\212\r\026\007\027\036\027\022\024)]TJ /Span<>> BDC ( )Tj EMC 6.794 0 Td [(\025.\200., )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 2.839 0 Td [(\f\024\026\r\021. )0.5(\221\r\016\034 )]TJ 0.318 Tw -22.588 -1.25 Td (\n\031\021\026\006\017\005 \020\036\027\026 )Tj /T1_2 1 Tf 0 Tw [(KRA)50(S)]TJ /T1_1 1 Tf 0.318 Tw ( \f)Tj /Span<>> BDC ( )Tj EMC (\022\035\017\027\017\022\024-\023\026\021\024\035\024\020\017\004\036\f\022\ \017\n\017 \024\f\024\002\036\027\027\024\f\021\016\n\017 )Tj 0.184 Tw T* (\022\024\035\024\030\036\022\021\026\035\034\027\024\020\024 \030\026\022\ \026 \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \033\020\026 \217\024\f\f\017\017. )Tj /T1_2 1 Tf 0 Tw (\240\031\204\030\205\021\026\032\n\030\021\020\017 )Tj 0.014 Tc 0.523 Tw T* (\204\205\032\021\026\023 \r\013\t\033\031\032\025\003\031\021\024\026\023\ \022\021\n\202\n \n\005\032\026\016\n\027\026\021\025\002.)Tj /T1_1 1 Tf [( 2014;1-1: 65-68.)14( )]TJ 0.015 Tc 0.555 Tw T* (\212\024\f\021\031\023\027\024 \023\024)Tj /Span<>> BDC ( )Tj EMC [(ht)-30.2(tps://e)-18.1(xpeduca)14.8(t)-32.1(ion.r)-22.1(u/r)-22.1(u/ar)-22.1(t)-32.2(icle/v)-16.1(iew?id=4517)15( )]TJ 0 Tc 0.023 Tw T* (\(\007\026\021\026 \024\002\030\026\013\036\027\017\016: 20.01.2023\).)Tj 0.096 Tw 29.055 30 Td (7.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (\025\017\021)Tj /Span<>> BDC ( )Tj EMC (\210.\222., \206\036\r\024\030\022\016\027)Tj /Span<>> BDC ( )Tj EMC (\236.\202., \221\024\035\007\026\021\022\017\027\026)Tj /Span<>> BDC ( )Tj EMC (\203.\200., \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. \217\036\031\035\034\021\026\021\t )Tj 0.256 Tw -1.296 -1.25 Td (\023\024\r\021\024\030\027\t\b \030\036\036\022\006\017\005 \023\036\004\ \036\027\017 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\n\036\021\026\f\021\026\021\017\004\036\f\022\024\n \022\024\035\024\030\ \036\022\021\026\035\034)Tj 0 Tw (-)Tj 0.258 Tw T* [(\027\024\n )0.6(\030\026\022\036. )]TJ /T1_2 1 Tf 4.752 0 Td [(\206\025\032\205\032\202\025\002. )0.6(\241\205\032\021\026\023 )0.6(\025\003. )0.6(\217.\215. )0.6(\025\032\n\202\n\027\026. )]TJ /T1_1 1 Tf 0 Tw 16.927 0 Td (2022;8:45\22652. )Tj -21.679 -1.25 Td [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td [(10.17116/hir)-21.9(ur)-32(gia202208145)]TJ 0 0 0 1 k /GS1 gs 0.062 Tw -1.847 -1.25 Td (8.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (Ahmad)Tj /Span<>> BDC ( )Tj EMC [(NZ, A)-14(bbas)]TJ /Span<>> BDC ( )Tj EMC (MH, Khan)Tj /Span<>> BDC ( )Tj EMC [(SU, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC (al. \202)Tj /Span<>> BDC ( )Tj EMC [(me)-12(t)15(a-anal)35(y)-12.9(sis of t)-13(he r)-32(ole )]TJ -0.027 Tw -1.296 -1.25 Td [(of di)-16(ver)-21.9(t)-32(ing ileost)17.1(omy af)-28(ter r)-24(ec)-16(t)15.1(al cancer sur)-31.9(ger)-24(y. )]TJ /T1_2 1 Tf (Int J Colorectal Dis.)Tj /T1_1 1 Tf 0 Tw ( )Tj 0.023 Tw T* [(2021 Mar;36\(3\):445\226455. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1007/s00384-020-03771-z)Tj 0 0 0 1 k /GS1 gs 0.147 Tw T* (9.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(T)40(ao)]TJ /Span<>> BDC ( )Tj EMC (K, Gao)Tj /Span<>> BDC ( )Tj EMC [(J, W)22(ei)]TJ /Span<>> BDC ( )Tj EMC [(Z, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. R)-24(isk f)16(a)-17(c)-15.9(t)17(or)-10(s for anast)17(omo)17(t)-32(ic leak)-17(a)-17(ge )]TJ 0.132 Tw -1.296 -1.25 Td [(af)-28(ter r)-24(ec)-15.9(t)15(al cancer sur)-32(ger)-24(y. )]TJ /T1_2 1 Tf 0 Tw (Chinese. )Tj /T1_1 1 Tf 0.132 Tw 15.27 0 Td [(2018 Apir)-30(l 25;21\(4\):384\226387. )]TJ 0.023 Tw -15.27 -1.25 Td (PMID: 29682707.)Tj -0.017 Tw T* (10.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (\025\017\021)Tj /Span<>> BDC ( )Tj EMC (\210.\222., \206\036\r\024\030\022\016\027)Tj /Span<>> BDC ( )Tj EMC (\236.\202., \221\024\035\007\026\021\022\017\027\026)Tj /Span<>> BDC ( )Tj EMC (\203.\200., \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. \202\023\023\026\030\026\021\027\t\005 )Tj 0.015 Tc 0.555 Tw -1.796 -1.25 Td (\n\036\032\022\017\001\036\004\027\t\005 \026\027\026\f\021\024\n\024 \023\ \030\017)Tj /Span<>> BDC ( )Tj EMC (\022\024\035\024\030\036\022\021\026\035\034\027\024\n \030\026\022\036:\ \027\036\023\024)Tj 0 Tc 0 Tw (-)Tj 0.016 Tc 0.576 Tw T* (\f\030\036\007\f\021\r\036\027\027\t\036 \030\036\031\035\034\021\026\021\ \t. )Tj /T1_2 1 Tf -0.016 Tw (\222\n\023\n\033\032\n\013\024\n\023\n\202\025\002.)Tj /T1_1 1 Tf 0.576 Tw [( 2016;1:48\22653.)16( )]TJ 0 Tc 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.33878/2073-7556-2016-0-1-48-53)Tj 0 0 0 1 k /GS1 gs 0.336 Tw -1.847 -1.25 Td (11.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(K)25(ope)-12(tz)]TJ /Span<>> BDC ( )Tj EMC (S, Chang)Tj /Span<>> BDC ( )Tj EMC [(GJ, O)-24(ver)-16(man)]TJ /Span<>> BDC ( )Tj EMC [(MJ, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Im)10(p)25(r)-32(oved sur)-32(v)-16(i)-15.9(v)-15(al )]TJ 0.001 Tc 0.349 Tw -1.796 -1.25 Td [(in me)-11.9(t)15.1(ast)15.1(a)15.1(t)-32(ic col)30.1(or)-23.9(ec)-15.9(t)15(al cancer is asso)-16(c)-23.9(ia)15.1(ted wi)-24(t)-12.9(h ad)-16(opt)-31.9(ion of)1( )]TJ 0 Tc 0.319 Tw T* [(hep)32(a)15(t)-32(ic r)-23.9(esec)-16(t)-32(ion and im)10(p)25(r)-32(oved )0.5(chemo)17(t)-13(her)-33(apy. )]TJ /T1_2 1 Tf 20.798 0 Td [(J Clinical )0.5(Oncol.)]TJ /T1_1 1 Tf 0 Tw ( )Tj 0.023 Tw -20.798 -1.25 Td [(2009;27\(22\):3677\22683. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw [(10.1200/JC)13(O.2008.20.5278)]TJ 0 0 0 1 k /GS1 gs 0.341 Tw T* (12.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Dossa)Tj /Span<>> BDC ( )Tj EMC 2.87 0 Td [(F, )0.6(A)-25(cuna)]TJ /Span<>> BDC ( )Tj EMC 4.274 0 Td [(SA, )0.6(R)-24(ickles)]TJ /Span<>> BDC ( )Tj EMC 5.178 0 Td [(A)35(S, )0.6(e)-12(t)]TJ /Span<>> BDC ( )Tj EMC 3.145 0 Td [(al. )0.6(Asso)-16(c)-24(ia)15(t)-32(ion )0.6(Be)-12(t)-32(ween )]TJ 0.04 Tw -17.263 -1.25 Td [(A)15(d)17(juv)-15(ant Chemo)17.1(t)-13(her)-33(apy and O)-24(ver)-32.9(all Sur)-32(v)-16(i)-16(v)-14.9(al in P)40(a)15(t)-31.9(ients W)-16(i)-24(t)-13(h R)13(ec)-16(t)15(al )]TJ 0.007 Tc 0.349 Tw T* [(Cancer and P)40.1(a)15.1(t)-12.8(hol)30.1(o)-15.9(gical Com)10.1(ple)-11.9(te R)13(esponse Af)-27.9(ter Neoad)17.1(juv)-14.9(ant)7( )]TJ 0.35 Tw T* [(Chemo)16.7(t)-13.3(her)-33.3(apy and R)12.6(esec)-16.3(t)-32.3(ion. )]TJ /T1_2 1 Tf [(J)29.7(AMA Oncol.)]TJ /T1_1 1 Tf [( 2018;4\(7\):930\226937.)7.1( )]TJ 0 Tc 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1001/jamaoncol.2017.5597)Tj 0 0 0 1 k /GS1 gs -0.028 Tw -1.847 -1.25 Td (13.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Joye)Tj /Span<>> BDC ( )Tj EMC [(I, Hauster)-15.9(mans)]TJ /Span<>> BDC ( )Tj EMC [(K. Which P)40(a)15(t)-32(ients W)-16(i)-23.9(t)-13(h R)13(ec)-16(t)15(al Cancer Do N)-14(o)17(t )]TJ 0.185 Tw -1.796 -1.25 Td [(Need R)-10(adio)17(t)-13(her)-32.9(apy? )]TJ /T1_2 1 Tf [(Semin R)20(adiat Oncol.)]TJ /T1_1 1 Tf ( 2016 Jul;26\(3\):199\226204. )Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 0 Tw 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\033\030\031\030\213\b)-20.9(\035\231\213\233\t \021\032)50(\b)42(\032\231\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj /T1_5 1 Tf 25 0 0 25 512.8394 56.0378 Tm (57)Tj ET endstream endobj 1977 0 obj <>/Border[0 0 0]/H/N/Rect[57.2978 289.595 158.225 280.299]/Subtype/Link/Type/Annot>> endobj 1978 0 obj <>/Border[0 0 0]/H/N/Rect[229.11 259.595 263.622 250.139]/Subtype/Link/Type/Annot>> endobj 1979 0 obj <>/Border[0 0 0]/H/N/Rect[42.5197 249.595 98.7913 240.299]/Subtype/Link/Type/Annot>> endobj 1980 0 obj <>/Border[0 0 0]/H/N/Rect[121.315 199.595 211.699 190.299]/Subtype/Link/Type/Annot>> endobj 1981 0 obj <>/Border[0 0 0]/H/N/Rect[289.739 299.595 385.586 290.299]/Subtype/Link/Type/Annot>> endobj 1982 0 obj <>/Border[0 0 0]/H/N/Rect[374.991 269.595 471.814 260.299]/Subtype/Link/Type/Annot>> endobj 1983 0 obj <>/Border[0 0 0]/H/N/Rect[289.739 199.595 412.546 190.299]/Subtype/Link/Type/Annot>> endobj 1984 0 obj <>/Border[0 0 0]/H/N/Rect[365.381 159.595 454.084 150.299]/Subtype/Link/Type/Annot>> endobj 1985 0 obj <>/Border[0 0 0]/H/N/Rect[289.739 109.595 389.514 100.299]/Subtype/Link/Type/Annot>> endobj 1994 0 obj <> endobj 1993 0 obj <> endobj 1992 0 obj <> endobj 1991 0 obj <> endobj 1990 0 obj <> endobj 1989 0 obj <> endobj 1988 0 obj <> endobj 1987 0 obj <> endobj 1986 0 obj <> endobj 1939 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 70.936 724.8299 Tm [(\037\036)10(\032\223\212\226\034\022\031\034)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0 Tc -0.011 Tw 10 0 0 10 70.8661 700.4739 Tm (\210\020\030\026\027\017\004\036\027\017\016 \007\026\027\027\024\020\024\ \017\f\f\035\036\007\024\r\026\027\017\016 \002\t\035\017 \024\002\031\f\ \035\024\r\035\036)Tj 0 Tw (-)Tj 0.029 Tw 0 -1.218 TD (\027\t \002\024\035\034\001\017\n \f\023\036\022\021\030\024\n \024\021\007\ \026\035\036\027\027\024\020\024 \n\036\021\026\f\021\026\021\017\004\036\ \f\022\024\020\024 )Tj 0.229 Tw T* (\023\024\030\026\032\036\027\017\016 \031)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\034\027\t\b \030\026\022\024\n \023\030\016\n\024\005 \022\017\ \001\022\017, \r\022\035\033)Tj 0 Tw (-)Tj 0.064 Tw T* (\004\036\027\027\t\b \r)Tj /Span<>> BDC ( )Tj EMC (\r\t\002\024\030\022\031, \026)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\032\036 \035\024\022\026\035\017\026\006\017\036\005 \023\036\ \030\r\017\004\027\024\005 )Tj 0.32 Tw T* (\024\023\031\b\024\035\017 \r\024 \r\f\036\b \024\021\007\036\035\026\b \ \023\030\016\n\024\005 \022\017\001\022\017: \r\036\030\b\027\036-, )Tj 0.333 Tw 0 -1.218 TD (\f\030\036\007\027\036- \017)Tj /Span<>> BDC ( )Tj EMC (\027\017\032\027\036\026\n\023\031\035\016\030\027\t\005. \210\f\027\024\ \r\027\t\n \031\f\035\024\r\017\036\n )Tj 0.069 Tw 0 -1.218 TD (\r\022\035\033\004\036\027\017\016 \023\026\006\017\036\027\021\024\r \r\ )Tj /Span<>> BDC ( )Tj EMC (\017\f\f\035\036\007\024\r\026\027\017\036 \002\t\035\024 \027\026\035\017\ \004\017\036 )Tj 0.265 Tw T* [(\030\036\036\022\021\026\002\036\035\034\027\024\005 )0.5(\023\036\030\r\017\004\027\024\005 \024\023\031\b\024\035\017 \023\030\016\ \n\024\005 \022\017\001\022\017 )]TJ 0 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\027\036\030\036\036\022\021\026\002\036\035\034\027\t\b \024\021\007\026\ \035\036\027\027\t\b \n\036\021\026\f\021\026\t.)Tj 0.189 Tw T* (\207\024\035\034\027\t\036 \023\024\035\031\004\017\035\017 \022\024\n\023\ \035\036\022\f\027\024\036 \035\036\004\036\027\017\036, \r\022\035\033\004\ \026\033)Tj 0 Tw (-)Tj 0.238 Tw 0 -1.218 TD [(\013\036\036 \024\023\036\030\026\021\017\r\027\024\036 \035\036\004\036\ \027\017\036, )0.5(\035\036\022\026\030\f\021\r\036\027\027\031\033 \021\036\030\026\023\017\ \033 )]TJ 0.031 Tw 0 -1.218 TD (\017)Tj /Span<>> BDC ( )Tj EMC (\023\030\036\007\024\023\036\030\026\006\017\024\027\027\031\033 \035\031\ \004\036\r\031\033 \021\036\030\026\023\017\033 \031)Tj /Span<>> BDC ( )Tj EMC (\004\026\f\021\017 \002\024\035\034)Tj 0 Tw (-)Tj 0.004 Tw 0 -1.218 TD [(\027\t\b. )0.6(\215\024\f\035\036 )0.5(\b\017\030\031\030\020\017\004\036\f\022\024\020\024 )0.6(\r\n\036\001\026\021\036\035\034\f\021\r\026 )0.5(\023\024)]TJ /Span<>> BDC ( )Tj EMC 19.195 0 Td (\023\024\r\024\007\031 )Tj 0.212 Tw -19.195 -1.218 Td (\030\026\022\026 \023\030\016\n\024\005 \022\017\001\022\017 \024\023\026\ \f\027\t\n \024\f\035\024\032\027\036\027\017\036\n \016\r\035\016\036\021\ )Tj 0 Tw (-)Tj 0.249 Tw 0 -1.218 TD (\f\016 \027\036\f\024\f\021\024\016\021\036\035\034\027\024\f\021\034 \026\ \027\026\f\021\024\n\024\026, \004\026\f\021\024\021\026 \022\024\021\024\ \030\024\005, )Tj 0.293 Tw 0 -1.218 TD (\023\024)Tj /Span<>> BDC ( )Tj EMC (\007\026\027\027\t\n \035\017\021\036\030\026\021\031\030\t, \n\024\032\036\ \021 \007\024\f\021\017\020\026\021\034 25% [8]. )Tj 0.513 Tw 0 -1.218 TD [(\203\036\f\024\f\021\024\016\021\036\035\034\027\024\f\021\034 )0.6(\026\027\026\f\021\024\n\024\026 )0.5(\024\f\024\002\036\027\027\024 )0.5(\027\036\032\036\035\026)]TJ 0 Tw (-)Tj 0.078 Tw 0 -1.218 TD [(\021\036\035\034\027\026 )0.6(\031)]TJ /Span<>> BDC ( )Tj EMC 3.802 0 Td [(\002\024\035\034\027\t\b )0.6(\n\036\021\026\f\021\026\021\017\004\036\f\022\017\n )0.6(\030\026\022\024\n, )0.5(\023\024\f\022\024\035\034\022\031 )]TJ 0.334 Tw -3.802 -1.218 Td (\036\036 \030\026\r\017\021\017\036 \024\021\024\007\r\017\020\026\036\021\ \f\030\024\022\017 \023\030\024\r\036\007\036\027\017\016 \035\036\022\026\ \030)Tj 0 Tw (-)Tj 0.105 Tw 0 -1.218 TD (\f\021\r\036\027\027\024\005 \021\036\030\026\023\017\017, \022\024\021\024\ \030\026\016 \027\036\024\002\b\024\007\017\n\026 \220\021\024\005 \022\026\ \021\036\020\024)Tj 0 Tw (-)Tj 0.232 Tw 0 -1.218 TD (\030\017\017 \002\024\035\034\027\t\b. \215\030\024\r\036\007\036\027\027\ \t\036 \017\f\f\035\036\007\024\r\026\027\017\016 \r\t\016\r\017\035\017\ )Tj 0.134 Tw 0 -1.218 TD (\235\026\022\021\024\030\t \030\017\f\022\026 \030\026\r\017\021\017\016\ \027\036\f\024\f\021\024\016\021\036\035\034\027\024\f\021\017 \026\027\ \026\f\021\024)Tj 0 Tw (-)Tj 0.11 Tw T* (\n\024\026, \f\030\036\007\017 \022\024\021\024\030\t\b \027\026\017\002\ \024\035\036\036 \027\026\004\017\n\t\n\017 \016\r\035\016\033\021\f\016\ )Tj -0.034 Tw T* (\n\031\032\f\022\024\005 \023\024\035, \024\032\017\030\036\027\017\036 \ \017\035\017 \023\024\027\017\032\036\027\027\024\036 \023\017\021\026\027\ \017\036, \035\024)Tj 0 Tw (-)Tj 0.099 Tw T* (\022\026\035\017\026\006\017\016 \024\023\031\b\024\035\017 \r)Tj /Span<>> BDC ( )Tj EMC (\027\017\032\027\036\026\n\023\031\035\016\030\027\024\n \024\021\007\036\ \035\036 \023\030\016)Tj 0 Tw (-)Tj 0.022 Tw T* (\n\024\005 \022\017\001\022\017, \023\030\024\r\036\007\036\027\017\036 \ \023\030\036\007\024\023\036\030\026\006\017\024\027\027\024\005 \b\017\n\ \017\024\035\031)Tj 0 Tw (-)Tj 0.248 Tw T* (\004\036\r\024\005 \021\036\030\026\023\017\017, \027\026\035\017\004\017\ \036 \r\t\030\026\032\036\027\027\024\005 \022\024\n\024\030\002\017\007\ \027\024\005 )Tj 0.095 Tw T* (\023\026\021\024\035\024\020\017\017 \017)Tj /Span<>> BDC ( )Tj EMC (\007\030\031\020\017\036 [9]. \200)Tj /Span<>> BDC ( )Tj EMC (\007\026\027\027\024\n \017\f\f\035\036\007\024\r\026\027\017\017 \027\036\ )Tj 0 Tw (-)Tj -0.015 Tw T* [(\f\024\f\021\024\016\021\036\035\034\027\024\f\021\034 )0.6(\022\024\035\024\030\036\022\021\026\035\034\027\024\020\024 )0.6(\026\027\026\f\021\024\n\024\026 )0.5(\027\026\002\035\033)]TJ 0 Tw (-)Tj 0.06 Tw T* (\007\026\035\026\f\034 \r)Tj /Span<>> BDC ( )Tj EMC (\027\036\002\024\035\034\001\024\n \023\030\024\006\036\027\021\036 \f\035\ \031\004\026\036\r \(6%\), \023\030\017\004\036\n, )Tj 0.027 Tw T* (\021\024\035\034\022\024 \031)Tj /Span<>> BDC ( )Tj EMC (\021\036\b \002\024\035\034\027\t\b, \022\024\021\024\030\t\n \002\t\035\ \017 \r\t\023\024\035\027\036\027\t \027\017)Tj 0 Tw (-)Tj -0.006 Tw T* (\022\017\036 \023\036\030\036\007\027\017\036 \030\036\036\022\006\017\017\ \023\030\016\n\024\005 \022\017\001\022\017. \210\007\027\026\022\024 \f\ \021\026\021\017)Tj 0 Tw (-)Tj 0.131 Tw T* (\f\021\017\004\036\f\022\017\005 \026\027\026\035\017 \027\036 \r\t\016\ \r\017\035 \027\026\004\017\n\024\005 \026\r\017\f\017\n\024\f\021\017\ )Tj 0.375 Tw T* [(\004\026\f\021\024\021\t )0.5(\030\026\r\017\021\017\016 )0.5(\027\036\f\024\f\021\024\016\021\036\035\034\027\024\f\021\017 )0.5(\022\024\035\024\030\036\022\021\026\035\034)]TJ 0 Tw (-)Tj 0.294 Tw T* (\027\024\020\024 \026\027\026\f\021\024\n\024\026 \024\021 \007\030\031\ \020\017\b \022\035\017\027\017\004\036\f\022\017\b \235\026\022\021\024\ \030\024\r )Tj -0.015 Tw T* (\023\030\017)Tj /Span<>> BDC ( )Tj EMC (\n\036\021\026\f\021\026\021\017\004\036\f\022\024\n \030\026\022\036 \023\ \030\016\n\024\005 \022\017\001\022\017. \224\021\017 \007\026\027\027\t\ \036 )Tj 0.126 Tw T* (\n\024\020\031\021 \f\r\017\007\036\021\036\035\034\f\021\r\024\r\026\021\ \034 \024)Tj /Span<>> BDC ( )Tj EMC (\021\024\n, \004\021\024 \n\036\021\026\f\021\026\021\017\004\036\f\022\024\ \036 )Tj 0.022 Tw T* (\023\024\030\026\032\036\027\017\036 \024\021\007\026\035\036\027\027\t\b\ \024\030\020\026\027\024\r \027\036 \r\035\017\016\036\021 \027\026)Tj /Span<>> BDC ( )Tj EMC (\004\026\f\021\024\021\031 )Tj 0 Tw T* (\030\026\r\017\021\017\016 \027\036\f\024\f\021\024\016\021\036\035\034\ \027\024\f\021\017 \026\027\026\f\021\024\n\024\026.)Tj -0.006 Tc 0.007 Tw T* (\215\030\036\r\036\027\021\017\r\027\026\016 \017\035\036\024\f\021\024\n\ \026 \023\030\017\r\026\027\026 \f\n\016\020\004\017\021\034 \022\035\017\ \027\017\004\036)Tj 0 Tc 0 Tw (-)Tj -0.006 Tc -0.081 Tw T* (\f\022\017\036 \023\030\024\016\r\035\036\027\017\016 \030\026\r\017\r\001\ \036\005\f\016 \027\036\f\024\f\021\024\016\021\036\035\034\027\024\f\021\ \017 \026\027\026)Tj 0 Tc 0 Tw (-)Tj -0.006 Tc -0.015 Tw 0 -1.218 TD (\f\021\024\n\024\026 \017)Tj /Span<>> BDC ( )Tj EMC (\f\027\017\017\021\034 \004\017\f\035\024 \023\024\r\021\024\030\027\t\b\ \024\023\036\030\026\021\017\r\027\t\b \r\n\036)Tj 0 Tc 0 Tw (-)Tj -0.006 Tc 0.08 Tw 0 -1.218 TD (\001\026\021\036\035\034\f\021\r. \210\023\036\030\026\021\017\r\027\t\036\ \r\n\036\001\026\021\036\035\034\f\021\r\026 \023\024)Tj /Span<>> BDC ( )Tj EMC [(\026\022\030\t\021\017\033)-6( )]TJ 0.094 Tw 0 -1.218 TD (\017\035\036\024\f\021\024\n\t \r\t\023\024\035\027\016\033\021\f\016, \r\ )Tj /Span<>> BDC ( )Tj EMC (\f\030\036\007\027\036\n, \r)Tj /Span<>> BDC ( )Tj EMC (\f\030\024\022\017 2\2264)Tj /Span<>> BDC ( )Tj EMC (\n\036)Tj 0 Tc 0 Tw (-)Tj -0.006 Tc 0.208 Tw T* (\f\016\006\026 [10]. \200)Tj /Span<>> BDC ( )Tj EMC (\023\030\036\007\f\021\026\r\035\036\027\027\024\n \017\f\f\035\036\007\024\ \r\026\027\017\017 \031)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\034)Tj 0 Tc 0 Tw (-)Tj -0.006 Tc 0.129 Tw T* [(\027\t\b \n\036\021\026\f\021\026\021\017\004\036\f\022\017\n \030\026\022\ \024\n \023\030\016\n\024\005 \022\017\001\022\017 \026\022\030\t\021\017\ \036)-6( )]TJ 0.089 Tw 0 -1.218 TD [(\017\035\036\024\f\021\024\n\t \002\t\035\024 )0.5(\r\t\023\024\035\027\036\027\024 )0.5(\027\036 \r\f\036\n \002\024\035\034\027\t\n \(79%\).)-6( )]TJ 0.034 Tw 0 -1.218 TD (\025\026\032\007\024\n\031 \023\016\021\024\n\031 \002\024\035\034\027\024\ \n\031 \030\026\022\024\n \023\030\016\n\024\005 \022\017\001\022\017 \f\ )Tj /Span<>> BDC ( )Tj EMC (\n\036)Tj 0 Tc 0 Tw (-)Tj -0.006 Tc -0.033 Tw 0 -1.218 TD (\021\026\f\021\026\021\017\004\036\f\022\017\n \023\024\030\026\032\036\027\ \017\036\n \024\021\007\026\035\036\027\027\t\b \024\030\020\026\027\024\ \r \017\035\036\024)Tj 0 Tc 0 Tw (-)Tj -0.006 Tc 0.068 Tw 0 -1.218 TD (\f\021\024\n\026 \027\036 \002\t\035\026 \026\022\030\t\021\026, \026)Tj /Span<>> BDC ( )Tj EMC (\f\030\036\007\027\017\036 \f\030\024\022\017 \007\024)Tj /Span<>> BDC ( )Tj EMC [(\026\022\030\t\021\017\016)-6( )]TJ 0.268 Tw 0 -1.218 TD [(\f\024\f\021\026\r\017\035\017 18 \n\036\f\016\006\036\r. \211\004\017\021\ \t\r\026\016 \220\021\024\021 \235\026\022\021, \n\024\032\027\024)-6( )]TJ 0.329 Tw 0 -1.218 TD [(\023\030\036\007\023\024\035\024\032\017\021\034, \004\021\024 \004\026\f\ \021\034 \002\024\035\034\027\t\b \n\036\021\026\f\021\026\021\017\004\036\ \f\022\017\n)-6( )]TJ 0.168 Tw 23.244 64.543 Td [(\030\026\022\024\n \023\030\016\n\024\005 \022\017\001\022\017 \023\024\035\ \031\004\017\035\026 \002\t )0.5(\023\030\036\017\n\031\013\036\f\021\r\024 \024\021)-6( )]TJ 0 Tw T* (\235\024\030\n\017\030\024\r\026\027\017\016 \023\024\f\021\024\016\027\027\ \024\005 \022\024\035\024\f\021\024\n\t.)Tj 0 Tc 0.187 Tw T* (\215\024\022\026\026\021\036\035\017 \024\002\013\036\005 \017)Tj /Span<>> BDC ( )Tj EMC (\002\036\f\f\024\002\t\021\017\005\027\024\005 \r\t\032\017\r\026\036\n\024\ \f\021\017 )Tj 0.186 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\023\030\036\007\f\021\026\r\035\036\027\027\024\005 \020\030\031\023\023\ \036 \002\024\035\034\027\t\b \n\036\021\026\f\021\026\021\017\004\036\f\ \022\017\n )Tj 0.016 Tw T* (\030\026\022\024\n \023\030\016\n\024\005 \022\017\001\022\017 \f\024\f\021\ \026\r\017\035\017, \f\024\024\021\r\036\021\f\021\r\036\027\027\024, 24\ ,6 )Tj 0.003 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (18,5 \n\036\f\016\006\036\r, \004\021\024 \022\024\030\030\036\035\017\030\ \031\036\021 \f)Tj /Span<>> BDC ( )Tj EMC (\007\026\027\027\t\n\017 \035\017\021\036\030\026\021\031)Tj 0 Tw (-)Tj T* (\030\t [11].)Tj 0.257 Tw 0 -1.218 TD (\215\024\f\035\036 \024\023\036\030\026\021\017\r\027\024\020\024 \035\036\ \004\036\027\017\016 \007\026\035\034\027\036\005\001\036\036 \023\030\024\ \020\030\036\f)Tj 0 Tw (-)Tj 0.101 Tw 0 -1.218 TD (\f\017\030\024\r\026\027\017\036 \n\036\021\026\f\021\026\021\017\004\036\ \f\022\024\020\024 \023\024\030\026\032\036\027\017\016 \024\021\007\026\ \035\036\027\027\t\b )Tj 0.075 Tw T* (\024\030\020\026\027\024\r \027\026\002\035\033\007\026\035\024\f\034 \031\ )Tj /Span<>> BDC ( )Tj EMC (\002\024\035\034\001\017\027\f\021\r\026 \002\024\035\034\027\t\b \(71%\)\ )Tj 0.086 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\016\r\035\016\035\024\f\034 \004\026\013\036 \r\f\036\020\024\ \n\036\021\026\f\021\026\021\017\004\036\f\022\017\n \023\024\030\026\032\ \036)Tj 0 Tw (-)Tj 0.12 Tw T* (\027\017\036\n \023\036\004\036\027\017, \002\030\033\001\017\027\t \017\ )Tj /Span<>> BDC ( )Tj EMC [(\035\036\020\022\017\b. )0.5(\200)]TJ /Span<>> BDC ( )Tj EMC (\027\026\001\036\n \017\f\f\035\036\007\024)Tj 0 Tw (-)Tj 0.438 Tw 0 -1.218 TD (\r\026\027\017\017 \027\026\004\017\n\024 \031\b\031\007\001\017\035\024\ \r\t\032\017\r\026\036\n\024\f\021\034 \002\024\035\034\027\t\b )Tj 0.279 Tw 0 -1.218 TD (\023\030\024\020\030\036\f\f\017\030\024\r\026\027\017\036 \026\002\024\ \035\036\r\026\027\017\016, \f\r\016\026\027\027\024\036 \f)Tj /Span<>> BDC ( )Tj EMC (\n\036\021\026)Tj 0 Tw (-)Tj 0.154 Tw 0 -1.218 TD [(\f\021\026\021\017\004\036\f\022\017\n )0.6(\023\024\030\026\032\036\027\017\036\n )0.5(\002\030\033\001\017\027\t, )0.6(\023\036\004\036\027\017 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 19.827 0 Td (\n\031\035\034)Tj 0 Tw (-)Tj 0.332 Tw -19.827 -1.218 Td (\021\017\024\030\020\026\027\027\024\036 \023\024\030\026\032\036\027\017\ \036. \203\026\023\030\024\021\017\r \n\036\021\026\f\021\026\021\017\004\ \036\f\022\024\036 )Tj 0.085 Tw 0 -1.218 TD (\023\024\030\026\032\036\027\017\036 \035\036\020\022\017\b \027\026\004\ \017\n\024 \027\036 \023\024\r\035\017\016\035\024 \027\026)Tj /Span<>> BDC ( )Tj EMC (\r\t\032\017\r\026)Tj 0 Tw (-)Tj 0 -1.218 TD (\036\n\024\f\021\034 \023\026\006\017\036\027\021\024\r.)Tj -0.024 Tw 0 -1.218 TD [(\215\030\017 \026\027\026\035\017\036 )0.5(\030\036\031\035\034\021\026\021\024\r )0.5(\035\036\004\036\027\017\016 )0.5(\030\026\022\026 \023\030\016\n\024\005 \022\017\001\022\017 )]TJ -0.042 Tw 0 -1.218 TD (\f)Tj /Span<>> BDC ( )Tj EMC (\024\021\007\026\035\036\027\027\t\n\017 \n\036\021\026\f\021\026\026\n\ \017 \r)Tj /Span<>> BDC ( )Tj EMC (\026\r\017\f\017\n\024\f\021\017 \024\021 \r\026\030\017\026\027)Tj 0 Tw (-)Tj 0.041 Tw T* (\021\026 \035\036\004\036\027\017\016 \024\022\026\026\035\024\f\034, \004\ \021\024 \002\024\035\036\036 \r\t\f\024\022\017\036 \023\024\022\026\026\ \021\036\035\017 )Tj 0.201 Tw 0 -1.218 TD [(\r\t\032\017\r\026\036\n\024\f\021\017 )0.6(\002\t\035\017 )0.5(\023\024\035\031\004\036\027\t )0.6(\r)]TJ /Span<>> BDC ( )Tj EMC 14.384 0 Td [(\020\030\031\023\023\036 )0.5(\023\026\006\017\036\027\021\024\r, )]TJ -0.025 Tw -14.384 -1.218 Td (\022\024\021\024\030\t\036 \023\024\035\031\004\017\035\017 \b\017\030\031\ \030\020\017\004\036\f\022\024\036 \035\036\004\036\027\017\036 \017)Tj /Span<>> BDC ( )Tj EMC (\b\017\n\017\024\021\036)Tj 0 Tw (-)Tj 0.038 Tw 0 -1.218 TD [(\030\026\023\017\033 )0.5(\023\024)]TJ /Span<>> BDC ( )Tj EMC [(\f\030\026\r\027\036\027\017\033 )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC [(\023\026\006\017\036\027\021\026\n\017, )0.6(\031)]TJ /Span<>> BDC ( )Tj EMC [(\022\024\021\024\030\t\b )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC (\022\024\n)Tj 0 Tw (-)Tj 0.154 Tw T* (\023\035\036\022\f \035\036\004\036\027\017\016 \002\t\035\026 \r\022\035\ \033\004\036\027\026 \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\036\007\024\023\036\030\026\006\017\024\027\027\026\016 )Tj 0.089 Tw T* (\023\030\024\035\024\027\020\017\030\024\r\026\027\027\026\016 \035\031\004\ \036\r\026\016 \021\036\030\026\023\017\016. \216\031\007\001\017\036 \030\ \036\031\035\034)Tj 0 Tw (-)Tj 0.186 Tw T* [(\021\026\021\t )0.5(\035\036\004\036\027\017\016 )0.6(\002\024\035\034\027\t\b )0.6(\n\036\021\026\f\021\026\021\017\004\036\f\022\017\n )0.5(\030\026\022\024\n )0.5(\023\030\016)]TJ 0 Tw (-)Tj 0.084 Tw T* (\n\024\005 \022\017\001\022\017 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\r\022\035\033\004\036\027\017\017 \r)Tj /Span<>> BDC ( )Tj EMC (\022\024\n\023\035\036\022\f \035\036\004\036\027\017\016 \023\030\024)Tj 0 Tw (-)Tj 0.132 Tw T* (\035\024\027\020\017\030\024\r\026\027\027\024\005 \023\030\036\007\024\023\ \036\030\026\006\017\024\027\027\024\005 \035\031\004\036\r\024\005 \021\ \036\030\026\023\017\017 )Tj 0.301 Tw T* ([13] \n\024\032\027\024 \024\002\255\016\f\027\017\021\034 \026\007\036\ \030\032\022\024\005 \023\030\024\r\036\007\036\027\017\016 \b\017)Tj 0 Tw (-)Tj 0.096 Tw T* (\n\017\024\021\036\030\026\023\017\017 \r)Tj /Span<>> BDC ( )Tj EMC (\021\036\030\026\023\036\r\021\017\004\036\f\022\017\b \007\024\026\b \027\ \026)Tj /Span<>> BDC ( )Tj EMC (3\2264)Tj /Span<>> BDC ( )Tj EMC (\n\036\f\016\006\026 )Tj 0.034 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\f\r\016\017 \f)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\r\036\007\036\027\017\036\n \035\031\004\036\r\024\005 \021\ \036\030\026\023\017\017. \200)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\n \022\024\027)Tj 0 Tw (-)Tj -0.046 Tw T* (\021\036\022\f\021\036 \027\026\001\017 \007\026\027\027\t\036 \023\024\007\ \021\r\036\030\032\007\026\033\021 \030\036\031\035\034\021\026\021\t \007\ \030\031\020\017\b )Tj 0.223 Tw T* [(\017\f\f\035\036\007\024\r\026\027\017\005 )0.6([12\22614] )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 10.993 0 Td [(\f\r\017\007\036\021\036\035\034\f\021\r\031\033\021 )0.6(\r)]TJ /Span<>> BDC ( )Tj EMC 8.329 0 Td (\023\024\035\034\031 )Tj -0.038 Tw -19.322 -1.218 Td (\027\026\004\026\035\026 \035\036\004\036\027\017\016 \031)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\034\027\t\b \f)Tj /Span<>> BDC ( )Tj EMC (\020\036\027\036\030\026\035\017\024\r\026\027\027\t\n \030\026\022\024\ \n )Tj 0.056 Tw T* (\023\030\016\n\024\005 \022\017\001\022\017 \f)Tj /Span<>> BDC ( )Tj EMC (\f\017\f\021\036\n\027\024\005 \b\017\n\017\024\021\036\030\026\023\017\036\ \005 \r)Tj /Span<>> BDC ( )Tj EMC (\f\024\004\036\021\026)Tj 0 Tw (-)Tj T* (\027\017\017 \f)Tj /Span<>> BDC ( )Tj EMC (\021\026\030\020\036\021\027\t\n\017 \023\030\036\023\026\030\026\021\026\ \n\017.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 303.3769 249.8878 Tm [(\020)21(\026\027\r\242\224\034\022\031\034)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0 Tc 0.136 Tw 10 0 0 10 303.3071 225.5318 Tm [(\203\017\022\026\016 )0.5(\023\036\030\036\007\027\016\016 \030\036\036\022\006\017\016 )0.5(\023\030\016\n\024\005 )0.5(\022\017\001\022\017 \f)]TJ /Span<>> BDC ( )Tj EMC (\235\024\030\n\017)Tj 0 Tw (-)Tj 0.238 Tw T* (\030\024\r\026\027\017\036\n \023\030\036\r\036\027\021\017\r\027\024\005\ \017\035\036\024\f\021\024\n\t \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\n\036\021\026\f\021\026\021\017)Tj 0 Tw (-)Tj 0.214 Tw T* (\004\036\f\022\024\n \030\026\022\036 \f\024\023\030\024\r\024\032\007\026\ \036\021\f\016 \023\030\017\036\n\035\036\n\024\005 \004\026\f\021\024\021\ \024\005 )Tj 0.312 Tw T* (\027\036\f\024\f\021\024\016\021\036\035\034\027\024\f\021\017 \026\027\026\ \f\021\024\n\024\026 \(5,9%\) \017)Tj /Span<>> BDC ( )Tj EMC (\023\024\f\035\036\024\023\036)Tj 0 Tw (-)Tj 0.1 Tw T* (\030\026\006\017\024\027\027\024\005 \035\036\021\026\035\034\027\024\f\021\ \017 \(1,2%\). \211)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\034\027\t\b \f)Tj /Span<>> BDC ( )Tj EMC (\020\036\027\036\030\026)Tj 0 Tw (-)Tj 0.105 Tw T* (\035\017\024\r\026\027\027\024\005 \235\024\030\n\024\005 \030\026\022\026\ \023\030\016\n\024\005 \022\017\001\022\017 \023\030\036\007\023\024\004\ \021\017)Tj 0 Tw (-)Tj 0.073 Tw T* (\021\036\035\034\027\024 \027\026\004\017\027\026\021\034 \035\036\004\036\ \027\017\036 \f)Tj /Span<>> BDC ( )Tj EMC (\f\017\f\021\036\n\027\024\005 \b\017\n\017\024\021\036\030\026\023\017\017\ )Tj 0 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\f\024\004\036\021\026\027\017\017 \f)Tj /Span<>> BDC ( )Tj EMC (\021\026\030\020\036\021\027\t\n\017 \023\030\036\023\026\030\026\021\026\ \n\017.)Tj /T1_2 1 Tf 0.023 Tw 0 -2.436 TD (\223\030\032\255\020\034\036 \032\026\020\017\022\017\026)Tj /T1_1 1 Tf 0 Tw 0 -1.218 TD [(\025)-4.1(\024)-4.3(\027)1.7(\006)-6(\036)-6.8(\023)2.2(\006)-6(\017)-5.4(\016 \017)]TJ /Span<>> BDC ( )Tj EMC [(\007)-6(\017)2.7()-9.9(\026\005)1.8(\027 \017)-2.4(\f)3.1(\f)-38.9(\035)-6.8(\036)-19(\007)-4.4(\024)-4.3(\r)-8.9(\026\027)1.7(\017)-5.5(\016)13.7(:)]TJ /T1_3 1 Tf -0.029 Tc 0.029 Tw [( \222)-12.4(\025)-21.3(\024)]TJ /Span<>> BDC 16.858 0 Td ( )Tj EMC [(\255)-1.4(.\215.)]TJ /T1_1 1 Tf 0 Tc 0.559 Tw -16.858 -1.218 Td [(\221)-4.6(\002)-9.9(\024)0.7(\030 \017)]TJ /Span<>> BDC ( )Tj EMC [(\024)-11.8(\002)3(\030)-11.4(\026)-6.3(\002)-9.9(\024)-10.9(\021)-17.7(\022)-19.1(\026 \n)1.3(\026)-11.8(\021)-9.9(\036)-1.7(\030)-7.6(\017)-0.6(\026)-33.1(\035\026)3.7(:)]TJ /T1_3 1 Tf [( \213)1.1(\n)5.3(\021)6.6(\030)4.8(\026)1.9(\032\031)2.3(\021)10.7(\013)9.8(\n)]TJ /Span<>> BDC ( )Tj EMC [(\255)27.6(.)27.5(\222)8.6(.)7.8(, )]TJ 0 Tw T* [(\201)9.3(\021)10.1(\025)3.3(\t)6.4(\025)4.6(\003)4(\n)9.7(\027)]TJ /Span<>> BDC ( )Tj EMC [(\201)-2.3(.)30.3(\036)22.8(.)7.8(, \210)98(\205)6.7(\t)10.3(\026)1.8(\032\031)6.6(\027)2.1(\026)]TJ /Span<>> BDC ( )Tj EMC [(\240)19.4(.)7.3(\201)-2.3(.)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\033\030\031\030\213\b)-20.9(\035\231\213\233\t \021\032)50(\b)42(\032\231\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj -51.938 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 23, \023\0221)69(, 202)69(4)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 23, \023\0221)69(, 202)69(4)]TJ /T1_5 1 Tf 25 0 0 25 28.0651 56.0378 Tm (56)Tj ET endstream endobj 1824 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1825 0 obj <>/ExtGState<>/Font<>/ProcSet[/PDF/Text]/Properties<>/Shading<>/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1826 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1827 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1828 0 obj <>/Font<>/ProcSet[/PDF/Text]/Properties<>/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 2002 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\033\016\222)21(\215\007\216)21(\026)11(\013\026\020 \002\016\222\016\n\227\220\220 \221\002\205\024\025\203 \n\220\ \n\220 \221\002\220\022\024\016\026)11(\013\006)-10(\026)11(\013\026\220\017\016\006\n)10(\025\024\022\002\013\n\016)]TJ 42.522 0 Td [(Results of r)31(ectal r)31(esection in metastatic cancer)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0.114 Tw 10 0 0 10 274.9606 724.8299 Tm (\021\036\030\026\023\017\017 \f\024\f\021\026\r\017\035\026 32,5 \n\036\f\ \016\006\026, \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\r\036\007\036\027\017\017 \035\031)Tj 0 Tw (-)Tj 0 -1.218 TD (\004\036\r\024\005 \021\036\030\026\023\017\017)Tj /Span<>> BDC ( )Tj EMC (\227 15,8 \n\036\f\016\006\036\r \()Tj /T1_2 1 Tf (p)Tj /T1_1 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,004\) \(\217\017\f.)Tj /Span<>> BDC ( )Tj EMC (3\).)Tj 0.077 Tw T* (\200\t\032\017\r\026\036\n\024\f\021\034 \002\024\035\034\027\t\b \n\036\ \021\026\f\021\026\021\017\004\036\f\022\017\n \030\026\022\024\n \023\030\ \016)Tj 0 Tw (-)Tj 0.253 Tw T* (\n\024\005 \022\017\001\022\017 \021\026\022\032\036 \026\r\017\f\036\035\ \026 \017)Tj /Span<>> BDC ( )Tj EMC (\024\021 \027\026\035\017\004\017\016 \n\036\021\026\f\021\026)Tj 0 Tw (-)Tj 0.371 Tw T* (\021\017\004\036\f\022\024\020\024 \023\024\030\026\032\036\027\017\016 \ \023\036\004\036\027\017 \023\024\f\035\036 \024\023\036\030\026\021\017\ \r\027\024\020\024 )Tj 0.201 Tw T* [(\035\036\004\036\027\017\016. )0.5(\215\030\017)]TJ /Span<>> BDC ( )Tj EMC [(\220\021\024\n )0.5(\n\036\007\017\026\027\026 \r\t\032\017\r\026\036\n\024\f\021\017 )0.5(\023\030\017)]TJ /Span<>> BDC ( )Tj EMC 20.878 0 Td (\024\021)Tj 0 Tw (-)Tj 0.058 Tw -20.878 -1.218 Td [(\f\031\021\f\021\r\017\017 \n\036\021\026\f\021\026\021\017\004\036\f\022\ \024\020\024 )0.5(\023\024\030\026\032\036\027\017\016 \023\036\004\036\027\017 \f\024\f\021\ \026)]TJ 0 Tw (-)Tj 0.221 Tw T* (\r\017\035\026 33,4)Tj /Span<>> BDC ( )Tj EMC (\n\036\f\016\006\026, \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\n\036\021\026\f\021\026\021\017\004\036\f\022\024\n \023\024\030\026\032\ \036\027\017\017 )Tj 0.059 Tw T* (\023\036\004\036\027\017)Tj /Span<>> BDC ( )Tj EMC (\227 \r)Tj /Span<>> BDC ( )Tj EMC (2 \030\026\026 \n\036\027\034\001\036: 15,8 \n\036\f\016\006\026 \()Tj /T1_2 1 Tf 0 Tw (p)Tj /T1_1 1 Tf 0.059 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,0002\) )Tj 0 Tw T* (\(\217\017\f.)Tj /Span<>> BDC ( )Tj EMC (4\).)Tj 0.579 Tw T* (\210\006\036\027\022\026 \235\026\022\021\024\030\024\r \030\017\f\022\026\ \r\t\032\017\r\026\036\n\024\f\021\017 \002\024\035\034\027\t\b )Tj 0.247 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\023\030\017\n\036\027\036\027\017\036\n \030\036\020\030\036\f\f\017\024\ \027\027\024\005 \n\024\007\036\035\017 \023\030\024\023\024\030\006\017\ \024)Tj 0 Tw (-)Tj 0.227 Tw 0 -1.218 TD [(\027\026\035\034\027\t\b )0.6(\030\017\f\022\024\r )0.5(\025\024\022\f\026 )0.5(\023\024\022\026\026\035\026, )0.5(\004\021\024 )0.5(\022\026\027\006\036\030\024\n\026\021\024 )]TJ 0.063 Tw 0 -1.218 TD (\002\030\033\001\017\027\t \023\024\f\035\036 \035\036\004\036\027\017\016\ \r)Tj /Span<>> BDC ( )Tj EMC (4,1 \030\026\026 \023\024\r\t\001\026\036\021 \001\026\027\f\t )Tj 0.233 Tw 0 -1.218 TD (\031\n\036\030\036\021\034 \r)Tj /Span<>> BDC ( )Tj EMC (\035\033\002\024\005 \017\027\021\036\030\r\026\035 \r\030\036\n\036\027\ \017; \001\026\027\f\t \027\026\f\021\031)Tj 0 Tw (-)Tj 0.129 Tw T* (\023\035\036\027\017\016 \035\036\021\026\035\034\027\024\020\024 \017\f\ \b\024\007\026 \023\024\f\035\036 \024\023\036\030\026\006\017\017 \r)Tj /Span<>> BDC ( )Tj EMC (\035\033\002\024\n )Tj -0.006 Tw T* (\023\030\024\n\036\032\031\021\022\036 \r\030\036\n\036\027\017 \023\030\ \017)Tj /Span<>> BDC ( )Tj EMC (\027\026\035\017\004\017\017 \n\036\021\026\f\021\026\024\r \r)Tj /Span<>> BDC ( )Tj EMC (\023\036\004\036)Tj 0 Tw (-)Tj 0.114 Tw T* (\027\017 \r)Tj /Span<>> BDC ( )Tj EMC (2,9 \030\026 \r\t\001\036, \004\036\n \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\017\b \024\021\f\031\021\f\021\r\017\017; \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\023\030\024)Tj 0 Tw (-)Tj 0.417 Tw T* [(\r\036\007\036\027\017\017 \035\031\004\036\r\024\005 )0.5(\021\036\030\026\023\017\017 \002\036 \023\030\036\007\024\023\036\030\026\ \006\017\024\027\027\024\005 )]TJ 0.088 Tw T* (\b\017\n\017\024\021\036\030\026\023\017\017 \002\024\035\034\027\t\n \n\ \036\021\026\f\021\026\021\017\004\036\f\022\017\n \030\026\022\024\n \023\ \030\016)Tj 0 Tw (-)Tj 0.054 Tw T* (\n\024\005 \022\017\001\022\017 \001\026\027\f\t \035\036\021\026\035\034\ \027\024\020\024 \017\f\b\024\007\026 \r\t\001\036 \r)Tj /Span<>> BDC ( )Tj EMC (2,2 \030\026, )Tj 0.015 Tw T* [(\004\036\n )0.5(\023\030\017)]TJ /Span<>> BDC ( )Tj EMC [(\036\036 )0.5(\024\021\f\031\021\f\021\r\017\017. )0.5(\215\024\r\t\001\026\036\021 )0.5(\001\026\027\f\t \f\n\036\030\021\017 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 20.925 0 Td (1,5 )Tj 0.144 Tw -20.925 -1.218 Td (\017)Tj /Span<>> BDC ( )Tj EMC (\024\007\027\024\r\030\036\n\036\027\027\024\036 \023\024\030\026\032\036\ \027\017\036 \024\021\007\026\035\036\027\027\t\n\017 \n\036\021\026\f\021\ \026)Tj 0 Tw (-)Tj T* (\026\n\017 \027\036\f\022\024\035\034\022\017\b \024\030\020\026\027\024\ \r.)Tj -0.056 Tw T* (\221\021\026\021\017\f\021\017\004\036\f\022\017\005 \026\027\026\035\017\  \023\024\022\026\026\035, \004\021\024 \021\026\022\017\036 \023\024\022\ \026\026\021\036\035\017, )Tj 0.013 Tw T* (\022\026\022 \023\024\035, \r\024\030\026\f\021 \002\024\035\034\027\t\b\ , \f\021\036\023\036\027\034 \007\017\235\235\036\030\036\027\006\017\030\ \024\r\022\017 )Tj 0.331 Tw T* [(\024\023\031\b\024\035\017, )0.5(\n\036\021\026\f\021\026\021\017\004\036\f\022\024\036 )0.5(\023\024\030\026\032\036\027\017\036 )0.6(\030\036\020\017\024\027\026\030\027\t\b )]TJ -0.024 Tw T* (\035\017\n\235\024\031\035\024\r \027\026\004\017\n\024 \027\036 \r\035\ \017\016\035\017 \027\026)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\020\030\036\f\f\017\030\024\r\026\027\017\036 )Tj -0.02 Tw T* (\026\002\024\035\036\r\026\027\017\016 \023\024\f\035\036 \035\036\004\036\ \027\017\016 \017)Tj /Span<>> BDC ( )Tj EMC (\r\t\032\017\r\026\036\n\024\f\021\034 \002\024\035\034\027\t\b )Tj 0 Tw T* (\n\036\021\026\f\021\026\021\017\004\036\f\022\017\n \030\026\022\024\n \ \023\030\016\n\024\005 \022\017\001\022\017.)Tj ET 0 0 0 0 k /GS0 gs 42.52 570.362 221.102 165.49 re f /PlacedPDF /MC0 BDC 0 0.008 0.049 0 k 42.52 570.362 221.102 165.49 re f BT 0 0 0 1 k /GS1 gs /C2_0 1 Tf 4.495 0 0 4.648 129.4069 727.5025 Tm <024E>Tj 0.744 0 Td <026D>Tj 0.372 0 Td <0267>Tj 0.496 0 Td <0264>Tj 0.496 0 Td <0270>Tj 0.619 0 Td <0262>Tj 0.497 0 Td <0279>Tj /TT0 1 Tf 0.497 0 Td ( )Tj /C2_0 1 Tf 0.249 0 Td <023C>Tj 0.62 0 Td <0275>Tj 0.743 0 Td <0260>Tj 0.62 0 Td <0262>Tj 0.497 0 Td <025C>Tj 0.496 0 Td <025A>Tj 0.496 0 Td <025F>Tj 0.496 0 Td <0266>Tj 0.737 0 Td <0268>Tj 0.496 0 Td <026B>Tj 0.496 0 Td <026C>Tj 0.495 0 Td <0262>Tj ET q 42.52 570.362 221.102 165.49 re W n 0 0.994 1 0 K 0.557 w 2 J /GS0 gs q 1 0 0 1 128.292 722.2004 cm 0 0 m 0 0.471 0.372 0.849 0.836 0.849 c 1.3 0.849 1.672 0.471 1.672 0 c 1.672 -0.472 1.3 -0.849 0.836 -0.849 c 0.372 -0.849 0 -0.472 0 0 c h S Q Q BT /C2_0 1 Tf 4.495 0 0 4.648 133.8341 720.2371 Tm <0241>Tj 0.619 0 Td <025A>Tj 0.496 0 Td <025C>Tj 0.496 0 Td <025F>Tj 0.496 0 Td <026A>Tj 0.496 0 Td <0272>Tj /TT0 1 Tf 0.744 0 Td (.)Tj 0.249 0 Td ( )Tj 0.249 0 Td ( )Tj 0.249 0 Td ( )Tj ET 0 0.994 1 0 k /GS0 gs q 1 0 0 1 156.6783 721.908 cm 0 0 m 2.228 0 l h f Q 0 0.994 1 0 K 0.279 w 2 J q 1 0 0 1 156.6785 721.9082 cm 0 0 m 2.228 0 l 0 0 l h S Q q 1 0 0 1 157.7925 720.7947 cm 0 0 m 0 2.255 l h f Q q 1 0 0 1 157.7929 723.0492 cm 0 0 m 0 0 l 0 -2.254 l 0 0 l h S Q BT 0 0 0 1 k /GS1 gs /C2_0 1 Tf 4.495 0 0 4.648 162.6129 720.2371 Tm <0250>Tj 0.743 0 Td <025F>Tj 0.496 0 Td <0267>Tj 0.496 0 Td <0261>Tj 0.495 0 Td <026D>Tj 0.372 0 Td <026A>Tj 0.496 0 Td <0262>Tj 0.497 0 Td <026A>Tj /TT0 1 Tf 0.496 0 Td (.)Tj ET 0 0 0 0 k /GS0 gs 62.577 715.785 195.474 -127.026 re f* 0 0 0 0.25 K q 1 0 0 1 95.0585 589.3153 cm 0 0 m 0 126.47 l S Q q 1 0 0 1 127.5397 589.3153 cm 0 0 m 0 126.47 l S Q q 1 0 0 1 160.0212 589.3153 cm 0 0 m 0 126.47 l S Q q 1 0 0 1 192.5024 589.3153 cm 0 0 m 0 126.47 l S Q q 1 0 0 1 224.9842 589.3153 cm 0 0 m 0 126.47 l S Q q 1 0 0 1 62.577 600.8099 cm 0 0 m 194.916 0 l S Q q 1 0 0 1 62.577 612.305 cm 0 0 m 194.916 0 l S Q q 1 0 0 1 62.577 623.7995 cm 0 0 m 194.916 0 l S Q q 1 0 0 1 62.577 635.2941 cm 0 0 m 194.916 0 l S Q q 1 0 0 1 62.577 646.7892 cm 0 0 m 194.916 0 l S Q q 1 0 0 1 62.577 658.2838 cm 0 0 m 194.916 0 l S Q q 1 0 0 1 62.577 669.7783 cm 0 0 m 194.916 0 l S Q q 1 0 0 1 62.577 681.2729 cm 0 0 m 194.916 0 l S Q q 1 0 0 1 62.577 692.7677 cm 0 0 m 194.916 0 l S Q q 1 0 0 1 62.577 704.2626 cm 0 0 m 194.916 0 l S Q 0 0.994 1 0 K 0.557 w q 1 0 0 1 95.4206 691.4039 cm 0 0 m 1.615 0 l 1.615 -1.364 l 2.312 -1.364 l 2.312 -2.728 l 2.618 -2.728 l 2.618 -4.091 l 2.73 -4.091 l 2.73 -5.483 l 3.148 -5.483 l 3.148 -6.846 l 3.733 -6.846 l 3.733 -8.21 l 4.708 -8.21 l 4.708 -9.575 l 5.655 -9.575 l 5.655 -10.938 l 6.156 -10.938 l 6.156 -12.302 l 7.159 -12.302 l 7.159 -13.693 l 7.438 -13.693 l 7.438 -15.057 l 7.855 -15.057 l 7.855 -16.421 l 8.552 -16.421 l 8.552 -17.784 l 8.608 -17.784 l 8.608 -19.148 l 9.081 -19.148 l 9.081 -20.54 l 9.834 -20.54 l 9.834 -21.904 l 11.282 -21.904 l 11.282 -23.268 l 13.956 -23.268 l 13.956 -24.631 l 14.012 -24.631 l 14.012 -25.995 l 14.151 -25.995 l 14.151 -27.359 l 15.6 -27.359 l 15.6 -28.751 l 15.934 -28.751 l 15.934 -30.114 l 17.996 -30.114 l 17.996 -31.478 l 17.996 -32.842 l 18.33 -32.842 l 18.33 -34.206 l 18.859 -34.206 l 18.859 -35.569 l 19.249 -35.569 l 19.249 -36.961 l 19.946 -36.961 l 19.946 -38.325 l 21.004 -38.325 l 21.004 -39.689 l 21.952 -39.689 l 21.952 -41.053 l 23.205 -41.053 l 23.205 -42.416 l 23.985 -42.416 l 23.985 -43.808 l 25.322 -43.808 l 25.322 -45.172 l 25.768 -45.172 l 25.768 -46.536 l 26.715 -46.536 l 26.715 -47.899 l 30.086 -47.899 l 30.086 -49.263 l 33.401 -49.263 l 33.401 -50.627 l 34.626 -50.627 l 34.626 -52.018 l 38.638 -52.018 l 38.638 -53.438 l 39 -53.438 l 39 -54.885 l 39.752 -54.885 l 39.752 -56.305 l 40.727 -56.305 l 40.727 -57.724 l 41.423 -57.724 l 41.423 -59.171 l 43.652 -59.171 l 43.652 -60.646 l 44.767 -60.646 l 44.767 -62.121 l 45.518 -62.121 l 45.518 -63.569 l 47.886 -63.569 l 47.886 -65.043 l 48.416 -65.043 l 48.416 -66.575 l 51.201 -66.575 l 51.201 -68.3 l 52.316 -68.3 l 52.316 -70.137 l 52.678 -70.137 l 52.678 -71.946 l 54.071 -71.946 l 54.071 -73.755 l 56.271 -73.755 l 56.271 -75.648 l 58.444 -75.648 l 58.444 -77.763 l 72.233 -77.763 l 72.233 -81.02 l 72.763 -81.02 l 72.763 -84.276 l 88.642 -84.276 l 96.776 -84.276 l 107.027 -84.276 l 107.779 -84.276 l 116.972 -84.276 l 120.538 -84.276 l 120.761 -84.276 l 139.035 -84.276 l 142.405 -84.276 l S Q 0 0.994 1 0 k q 1 0 0 1 94.3065 691.2648 cm 0 0 m 2.228 0 l h f Q 0.279 w q 1 0 0 1 94.3062 691.2648 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 95.4207 690.1515 cm 0 0 m 0 2.227 l h f Q q 1 0 0 1 95.4206 692.3781 cm 0 0 m 0 0 l 0 -2.227 l 0 0 l h S Q q 1 0 0 1 95.9778 690.1515 cm 0 0 m 2.228 0 l h f Q q 1 0 0 1 95.9775 690.1515 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 97.092 689.0382 cm 0 0 m 0 2.227 l h f Q q 1 0 0 1 97.0919 691.2648 cm 0 0 m 0 0 l 0 -2.227 l 0 0 l h S Q q 1 0 0 1 96.5349 688.4811 cm 0 0 m 2.228 0 l h f Q q 1 0 0 1 96.5347 688.4814 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 97.6491 687.3678 cm 0 0 m 0 2.227 l h f Q q 1 0 0 1 97.6492 689.5948 cm 0 0 m 0 0 l 0 -2.227 l 0 0 l h S Q q 1 0 0 1 97.092 687.3687 cm 0 0 m 2.228 0 l h f Q q 1 0 0 1 97.0919 687.3685 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 98.2062 686.2545 cm 0 0 m 0 2.227 l h f Q q 1 0 0 1 98.2061 688.4814 cm 0 0 m 0 0 l 0 -2.227 l 0 0 l h S Q q 1 0 0 1 97.092 685.6983 cm 0 0 m 2.228 0 l h f Q q 1 0 0 1 97.0919 685.6984 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 98.2062 684.585 cm 0 0 m 0 2.227 l h f Q q 1 0 0 1 98.2061 686.8118 cm 0 0 m 0 0 l 0 -2.227 l 0 0 l h S Q q 1 0 0 1 97.6491 684.585 cm 0 0 m 2.229 0 l h f Q q 1 0 0 1 97.6492 684.5851 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 98.7633 683.4717 cm 0 0 m 0 2.227 l h f Q q 1 0 0 1 98.7633 685.6984 cm 0 0 m 0 0 l 0 -2.227 l 0 0 l h S Q q 1 0 0 1 98.2062 682.9155 cm 0 0 m 2.228 0 l h f Q q 1 0 0 1 98.2061 682.9152 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 99.3204 681.8022 cm 0 0 m 0 2.227 l h f Q q 1 0 0 1 99.3205 684.0284 cm 0 0 m 0 0 l 0 -2.227 l 0 0 l h S Q q 1 0 0 1 98.7633 681.8013 cm 0 0 m 2.228 0 l h f Q q 1 0 0 1 98.7633 681.8018 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 99.8775 680.6889 cm 0 0 m 0 2.227 l h f Q q 1 0 0 1 99.8777 682.9152 cm 0 0 m 0 0 l 0 -2.227 l 0 0 l h S Q q 1 0 0 1 99.8775 680.6889 cm 0 0 m 2.229 0 l h f Q q 1 0 0 1 99.8777 680.6885 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 100.9917 679.5756 cm 0 0 m 0 2.226 l h f Q q 1 0 0 1 100.9918 681.8018 cm 0 0 m 0 0 l 0 -2.227 l 0 0 l h S Q q 1 0 0 1 100.4346 679.0185 cm 0 0 m 2.228 0 l h f Q q 1 0 0 1 100.4346 679.0185 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 101.5488 677.9052 cm 0 0 m 0 2.227 l h f Q q 1 0 0 1 101.549 680.1318 cm 0 0 m 0 0 l 0 -2.227 l 0 0 l h S Q q 1 0 0 1 101.5488 677.9052 cm 0 0 m 2.229 0 l h f Q q 1 0 0 1 101.549 677.9055 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 102.663 676.7919 cm 0 0 m 0 2.227 l h f Q q 1 0 0 1 102.6635 679.0185 cm 0 0 m 0 0 l 0 -2.227 l 0 0 l h S Q q 1 0 0 1 101.5488 676.2357 cm 0 0 m 2.229 0 l h f Q q 1 0 0 1 101.549 676.2355 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 102.663 675.1224 cm 0 0 m 0 2.227 l h f Q q 1 0 0 1 102.6635 677.3488 cm 0 0 m 0 0 l 0 -2.227 l 0 0 l h S Q q 1 0 0 1 102.1059 675.1224 cm 0 0 m 2.229 0 l h f Q q 1 0 0 1 102.1062 675.1221 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 103.2201 674.0091 cm 0 0 m 0 2.227 l h f Q q 1 0 0 1 103.2204 676.2355 cm 0 0 m 0 0 l 0 -2.227 l 0 0 l h S Q q 1 0 0 1 102.663 673.452 cm 0 0 m 2.229 0 l h f Q q 1 0 0 1 102.6635 673.4521 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 103.7772 672.3387 cm 0 0 m 0 2.227 l h f Q q 1 0 0 1 103.7776 674.5654 cm 0 0 m 0 0 l 0 -2.227 l 0 0 l h S Q q 1 0 0 1 102.663 672.3387 cm 0 0 m 2.229 0 l h f Q q 1 0 0 1 102.6635 672.3388 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 103.7772 671.2254 cm 0 0 m 0 2.227 l h f Q q 1 0 0 1 103.7776 673.4521 cm 0 0 m 0 0 l 0 -2.227 l 0 0 l h S Q q 1 0 0 1 103.2201 670.6692 cm 0 0 m 2.229 0 l h f Q q 1 0 0 1 103.2204 670.6691 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 104.3352 669.5559 cm 0 0 m 0 2.227 l h f Q q 1 0 0 1 104.3348 671.7822 cm 0 0 m 0 0 l 0 -2.227 l 0 0 l h S Q q 1 0 0 1 104.3352 669.5559 cm 0 0 m 2.228 0 l h f Q q 1 0 0 1 104.3348 669.5558 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 105.4485 668.4426 cm 0 0 m 0 2.227 l h f Q q 1 0 0 1 105.4489 670.6691 cm 0 0 m 0 0 l 0 -2.227 l 0 0 l h S Q q 1 0 0 1 105.4485 667.8855 cm 0 0 m 2.229 0 l h f Q q 1 0 0 1 105.4489 667.8857 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 106.5636 666.7443 cm 0 0 m 0 2.255 l h f Q q 1 0 0 1 106.5633 668.9991 cm 0 0 m 0 0 l 0 -2.254 l 0 0 l h S Q q 1 0 0 1 108.2349 666.7443 cm 0 0 m 2.228 0 l h f Q q 1 0 0 1 108.2347 666.7448 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 109.3491 665.631 cm 0 0 m 0 2.255 l h f Q q 1 0 0 1 109.3491 667.8857 cm 0 0 m 0 0 l 0 -2.254 l 0 0 l h S Q q 1 0 0 1 108.2349 665.631 cm 0 0 m 2.228 0 l h f Q q 1 0 0 1 108.2347 665.6313 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 109.3491 664.5177 cm 0 0 m 0 2.227 l h f Q q 1 0 0 1 109.3491 666.7448 cm 0 0 m 0 0 l 0 -2.227 l 0 0 l h S Q q 1 0 0 1 108.2349 663.9615 cm 0 0 m 2.228 0 l h f Q q 1 0 0 1 108.2347 663.9614 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 109.3491 662.8482 cm 0 0 m 0 2.227 l h f Q q 1 0 0 1 109.3491 665.0747 cm 0 0 m 0 0 l 0 -2.227 l 0 0 l h S Q q 1 0 0 1 109.9062 662.8482 cm 0 0 m 2.229 0 l h f Q q 1 0 0 1 109.9063 662.8481 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 111.0204 661.7349 cm 0 0 m 0 2.227 l h f Q q 1 0 0 1 111.0204 663.9614 cm 0 0 m 0 0 l 0 -2.227 l 0 0 l h S Q q 1 0 0 1 110.4633 661.1778 cm 0 0 m 2.228 0 l h f Q q 1 0 0 1 110.4632 661.1781 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 111.5775 660.0645 cm 0 0 m 0 2.227 l h f Q q 1 0 0 1 111.5777 662.2914 cm 0 0 m 0 0 l 0 -2.227 l 0 0 l h S Q q 1 0 0 1 112.1346 660.0645 cm 0 0 m 2.229 0 l h f Q q 1 0 0 1 112.1349 660.0648 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 113.2488 658.9512 cm 0 0 m 0 2.227 l h f Q q 1 0 0 1 113.249 661.1781 cm 0 0 m 0 0 l 0 -2.227 l 0 0 l h S Q q 1 0 0 1 112.1346 658.395 cm 0 0 m 2.229 0 l h f Q q 1 0 0 1 112.1349 658.395 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 113.2488 657.2817 cm 0 0 m 0 2.227 l h f Q q 1 0 0 1 113.249 659.5081 cm 0 0 m 0 0 l 0 -2.227 l 0 0 l h S Q q 1 0 0 1 112.6917 657.2817 cm 0 0 m 2.229 0 l h f Q q 1 0 0 1 112.6918 657.2817 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 113.8059 656.1684 cm 0 0 m 0 2.227 l h f Q q 1 0 0 1 113.8062 658.395 cm 0 0 m 0 0 l 0 -2.227 l 0 0 l h S Q q 1 0 0 1 113.2488 655.6113 cm 0 0 m 2.229 0 l h f Q q 1 0 0 1 113.249 655.6118 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 114.363 654.4989 cm 0 0 m 0 2.227 l h f Q q 1 0 0 1 114.3634 656.7251 cm 0 0 m 0 0 l 0 -2.227 l 0 0 l h S Q q 1 0 0 1 113.8059 654.498 cm 0 0 m 2.229 0 l h f Q q 1 0 0 1 113.8062 654.4984 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 114.9201 653.3847 cm 0 0 m 0 2.227 l h f Q q 1 0 0 1 114.9204 655.6118 cm 0 0 m 0 0 l 0 -2.227 l 0 0 l h S Q q 1 0 0 1 114.363 652.8285 cm 0 0 m 2.229 0 l h f Q q 1 0 0 1 114.3634 652.8284 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 115.4772 651.7152 cm 0 0 m 0 2.227 l h f Q q 1 0 0 1 115.4776 653.9417 cm 0 0 m 0 0 l 0 -2.227 l 0 0 l h S Q q 1 0 0 1 115.4772 651.7152 cm 0 0 m 2.229 0 l h f Q q 1 0 0 1 115.4776 651.7153 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 116.5923 650.6019 cm 0 0 m 0 2.227 l h f Q q 1 0 0 1 116.592 652.8284 cm 0 0 m 0 0 l 0 -2.227 l 0 0 l h S Q q 1 0 0 1 116.0352 650.0457 cm 0 0 m 2.228 0 l h f Q q 1 0 0 1 116.0348 650.0454 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 117.1485 648.9324 cm 0 0 m 0 2.227 l h f Q q 1 0 0 1 117.1489 651.1587 cm 0 0 m 0 0 l 0 -2.227 l 0 0 l h S Q q 1 0 0 1 117.7065 648.9324 cm 0 0 m 2.228 0 l h f Q q 1 0 0 1 117.7061 648.9321 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 118.8207 647.8191 cm 0 0 m 0 2.227 l h f Q q 1 0 0 1 118.8206 650.0454 cm 0 0 m 0 0 l 0 -2.227 l 0 0 l h S Q q 1 0 0 1 118.2636 647.8191 cm 0 0 m 2.228 0 l h f Q q 1 0 0 1 118.2634 647.8187 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 119.3778 646.7058 cm 0 0 m 0 2.227 l h f Q q 1 0 0 1 119.3778 648.9321 cm 0 0 m 0 0 l 0 -2.227 l 0 0 l h S Q q 1 0 0 1 119.3778 646.1487 cm 0 0 m 2.228 0 l h f Q q 1 0 0 1 119.3778 646.1487 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 120.492 645.0354 cm 0 0 m 0 2.227 l h f Q q 1 0 0 1 120.4919 647.262 cm 0 0 m 0 0 l 0 -2.227 l 0 0 l h S Q q 1 0 0 1 119.9349 645.0354 cm 0 0 m 2.228 0 l h f Q q 1 0 0 1 119.9347 645.0354 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 121.0491 643.9221 cm 0 0 m 0 2.227 l h f Q q 1 0 0 1 121.0491 646.1487 cm 0 0 m 0 0 l 0 -2.227 l 0 0 l h S Q q 1 0 0 1 121.0491 643.365 cm 0 0 m 2.228 0 l h f Q q 1 0 0 1 121.0491 643.3654 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 122.1633 642.2517 cm 0 0 m 0 2.227 l h f Q q 1 0 0 1 122.1632 644.4788 cm 0 0 m 0 0 l 0 -2.227 l 0 0 l h S Q q 1 0 0 1 124.3917 642.2517 cm 0 0 m 2.229 0 l h f Q q 1 0 0 1 124.3918 642.2521 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 125.5059 641.1384 cm 0 0 m 0 2.227 l h f Q q 1 0 0 1 125.5062 643.3654 cm 0 0 m 0 0 l 0 -2.227 l 0 0 l h S Q q 1 0 0 1 127.7343 640.5822 cm 0 0 m 2.229 0 l h f Q q 1 0 0 1 127.7347 640.5822 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 128.8494 639.4689 cm 0 0 m 0 2.227 l h f Q q 1 0 0 1 128.8492 641.6954 cm 0 0 m 0 0 l 0 -2.227 l 0 0 l h S Q q 1 0 0 1 128.8494 639.4689 cm 0 0 m 2.228 0 l h f Q q 1 0 0 1 128.8492 639.4688 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 129.9636 638.3277 cm 0 0 m 0 2.255 l h f Q q 1 0 0 1 129.9633 640.5822 cm 0 0 m 0 0 l 0 -2.254 l 0 0 l h S Q q 1 0 0 1 132.7491 637.7706 cm 0 0 m 2.228 0 l h f Q q 1 0 0 1 132.749 637.7711 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 133.8633 636.6582 cm 0 0 m 0 2.227 l h f Q q 1 0 0 1 133.8632 638.8844 cm 0 0 m 0 0 l 0 -2.226 l 0 0 l h S Q q 1 0 0 1 133.3062 636.6582 cm 0 0 m 2.229 0 l h f Q q 1 0 0 1 133.3062 636.6583 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 134.4204 635.5449 cm 0 0 m 0 2.226 l h f Q q 1 0 0 1 134.4204 637.7711 cm 0 0 m 0 0 l 0 -2.226 l 0 0 l h S Q q 1 0 0 1 133.8633 634.9887 cm 0 0 m 2.228 0 l h f Q q 1 0 0 1 133.8632 634.9883 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 134.9775 633.8754 cm 0 0 m 0 2.226 l h f Q q 1 0 0 1 134.9776 636.1016 cm 0 0 m 0 0 l 0 -2.227 l 0 0 l h S Q q 1 0 0 1 134.9775 633.8754 cm 0 0 m 2.229 0 l h f Q q 1 0 0 1 134.9776 633.875 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 136.0917 632.7621 cm 0 0 m 0 2.227 l h f Q q 1 0 0 1 136.0918 634.9883 cm 0 0 m 0 0 l 0 -2.227 l 0 0 l h S Q q 1 0 0 1 135.5346 632.205 cm 0 0 m 2.229 0 l h f Q q 1 0 0 1 135.5349 632.205 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 136.6488 631.0917 cm 0 0 m 0 2.227 l h f Q q 1 0 0 1 136.649 633.3183 cm 0 0 m 0 0 l 0 -2.227 l 0 0 l h S Q q 1 0 0 1 137.763 630.5346 cm 0 0 m 2.229 0 l h f Q q 1 0 0 1 137.7634 630.535 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 138.8772 629.4213 cm 0 0 m 0 2.227 l h f Q q 1 0 0 1 138.8775 631.6483 cm 0 0 m 0 0 l 0 -2.227 l 0 0 l h S Q q 1 0 0 1 138.8772 629.4213 cm 0 0 m 2.229 0 l h f Q q 1 0 0 1 138.8775 629.4217 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 139.9923 628.308 cm 0 0 m 0 2.227 l h f Q q 1 0 0 1 139.9919 630.535 cm 0 0 m 0 0 l 0 -2.227 l 0 0 l h S Q q 1 0 0 1 139.9923 627.7518 cm 0 0 m 2.228 0 l h f Q q 1 0 0 1 139.9919 627.7517 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 141.1065 626.6385 cm 0 0 m 0 2.227 l h f Q q 1 0 0 1 141.1061 628.865 cm 0 0 m 0 0 l 0 -2.227 l 0 0 l h S Q q 1 0 0 1 142.2207 626.0814 cm 0 0 m 2.228 0 l h f Q q 1 0 0 1 142.2205 626.0817 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 143.3349 624.9681 cm 0 0 m 0 2.227 l h f Q q 1 0 0 1 143.3346 627.195 cm 0 0 m 0 0 l 0 -2.227 l 0 0 l h S Q q 1 0 0 1 142.7778 624.9681 cm 0 0 m 2.228 0 l h f Q q 1 0 0 1 142.7777 624.9684 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 143.892 623.8548 cm 0 0 m 0 2.227 l h f Q q 1 0 0 1 143.8918 626.0817 cm 0 0 m 0 0 l 0 -2.227 l 0 0 l h S Q q 1 0 0 1 145.5633 623.2986 cm 0 0 m 2.228 0 l h f Q q 1 0 0 1 145.5632 623.2984 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 146.6775 622.1853 cm 0 0 m 0 2.227 l h f Q q 1 0 0 1 146.6776 624.4117 cm 0 0 m 0 0 l 0 -2.227 l 0 0 l h S Q q 1 0 0 1 146.6775 621.072 cm 0 0 m 2.229 0 l h f Q q 1 0 0 1 146.6776 621.0717 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 147.7917 619.9587 cm 0 0 m 0 2.227 l h f Q q 1 0 0 1 147.792 622.1851 cm 0 0 m 0 0 l 0 -2.227 l 0 0 l h S Q q 1 0 0 1 147.2346 619.4025 cm 0 0 m 2.229 0 l h f Q q 1 0 0 1 147.2348 619.4023 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 148.3488 618.2892 cm 0 0 m 0 2.226 l h f Q q 1 0 0 1 148.3489 620.5151 cm 0 0 m 0 0 l 0 -2.226 l 0 0 l h S Q q 1 0 0 1 148.3488 617.7321 cm 0 0 m 2.229 0 l h f Q q 1 0 0 1 148.3489 617.7323 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 149.463 616.6188 cm 0 0 m 0 2.227 l h f Q q 1 0 0 1 149.4633 618.8456 cm 0 0 m 0 0 l 0 -2.227 l 0 0 l h S Q q 1 0 0 1 150.5772 615.5055 cm 0 0 m 2.229 0 l h f Q q 1 0 0 1 150.5775 615.5057 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 151.6923 614.3922 cm 0 0 m 0 2.227 l h f Q q 1 0 0 1 151.6919 616.619 cm 0 0 m 0 0 l 0 -2.227 l 0 0 l h S Q q 1 0 0 1 152.8065 613.836 cm 0 0 m 2.201 0 l h f Q q 1 0 0 1 152.8063 613.8357 cm 0 0 m 2.2 0 l 0 0 l h S Q q 1 0 0 1 153.8928 612.7227 cm 0 0 m 0 2.227 l h f Q q 1 0 0 1 153.8925 614.949 cm 0 0 m 0 0 l 0 -2.227 l 0 0 l h S Q q 1 0 0 1 166.707 610.4682 cm 0 0 m 2.228 0 l h f Q q 1 0 0 1 166.7071 610.4679 cm 0 0 m 2.228 0 l 0 0 l h S Q q 1 0 0 1 167.8212 609.3549 cm 0 0 m 0 2.227 l h f Q q 1 0 0 1 167.821 611.5813 cm 0 0 m 0 0 l 0 -2.227 l 0 0 l h S Q q 1 0 0 1 167.2641 607.1283 cm 0 0 m 2.228 0 l h f Q q 1 0 0 1 167.2643 607.1279 cm 0 0 m 2.228 0 l 0 0 l h S Q q 1 0 0 1 168.3783 606.015 cm 0 0 m 0 2.227 l h f Q q 1 0 0 1 168.3782 608.2413 cm 0 0 m 0 0 l 0 -2.227 l 0 0 l h S Q q 1 0 0 1 182.8638 607.1283 cm 0 0 m 2.229 0 l h f Q q 1 0 0 1 182.8639 607.1279 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 183.978 606.015 cm 0 0 m 0 2.227 l h f Q q 1 0 0 1 183.9783 608.2413 cm 0 0 m 0 0 l 0 -2.227 l 0 0 l h S Q q 1 0 0 1 191.2212 607.1283 cm 0 0 m 2.228 0 l h f Q q 1 0 0 1 191.2209 607.1279 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 192.3354 606.015 cm 0 0 m 0 2.227 l h f Q q 1 0 0 1 192.3353 608.2413 cm 0 0 m 0 0 l 0 -2.227 l 0 0 l h S Q q 1 0 0 1 201.2499 607.1283 cm 0 0 m 2.228 0 l h f Q q 1 0 0 1 201.2496 607.1279 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 202.3641 606.015 cm 0 0 m 0 2.227 l h f Q q 1 0 0 1 202.364 608.2413 cm 0 0 m 0 0 l 0 -2.227 l 0 0 l h S Q q 1 0 0 1 202.3641 607.1283 cm 0 0 m 2.228 0 l h f Q q 1 0 0 1 202.364 607.1279 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 203.4783 606.015 cm 0 0 m 0 2.227 l h f Q q 1 0 0 1 203.4784 608.2413 cm 0 0 m 0 0 l 0 -2.227 l 0 0 l h S Q q 1 0 0 1 211.2786 607.1283 cm 0 0 m 2.228 0 l h f Q q 1 0 0 1 211.2782 607.1279 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 212.3928 606.015 cm 0 0 m 0 2.227 l h f Q q 1 0 0 1 212.3926 608.2413 cm 0 0 m 0 0 l 0 -2.227 l 0 0 l h S Q q 1 0 0 1 214.6212 607.1283 cm 0 0 m 2.228 0 l h f Q q 1 0 0 1 214.6214 607.1279 cm 0 0 m 2.228 0 l 0 0 l h S Q q 1 0 0 1 215.7354 606.015 cm 0 0 m 0 2.227 l h f Q q 1 0 0 1 215.7353 608.2413 cm 0 0 m 0 0 l 0 -2.227 l 0 0 l h S Q q 1 0 0 1 215.1783 607.1283 cm 0 0 m 2.228 0 l h f Q q 1 0 0 1 215.1781 607.1279 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 216.2925 606.015 cm 0 0 m 0 2.227 l h f Q q 1 0 0 1 216.2925 608.2413 cm 0 0 m 0 0 l 0 -2.227 l 0 0 l h S Q q 1 0 0 1 233.5356 607.1283 cm 0 0 m 2.229 0 l h f Q q 1 0 0 1 233.536 607.1279 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 234.6507 606.015 cm 0 0 m 0 2.227 l h f Q q 1 0 0 1 234.6504 608.2413 cm 0 0 m 0 0 l 0 -2.227 l 0 0 l h S Q q 1 0 0 1 236.8791 607.1283 cm 0 0 m 2.228 0 l h f Q q 1 0 0 1 236.8792 607.1279 cm 0 0 m 2.228 0 l 0 0 l h S Q q 1 0 0 1 237.9933 606.015 cm 0 0 m 0 2.227 l h f Q q 1 0 0 1 237.9931 608.2413 cm 0 0 m 0 0 l 0 -2.227 l 0 0 l h S Q q 1 0 0 1 129.9636 639.4689 cm 0 0 m 2.228 0 l h f Q q 1 0 0 1 129.9633 639.4688 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 131.0778 638.3277 cm 0 0 m 0 2.255 l h f Q q 1 0 0 1 131.0777 640.5822 cm 0 0 m 0 0 l 0 -2.254 l 0 0 l h S Q q 1 0 0 1 130.5207 639.4689 cm 0 0 m 2.228 0 l h f Q q 1 0 0 1 130.5205 639.4688 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 131.6349 638.3277 cm 0 0 m 0 2.255 l h f Q q 1 0 0 1 131.6346 640.5822 cm 0 0 m 0 0 l 0 -2.254 l 0 0 l h S Q q 1 0 0 1 137.763 632.205 cm 0 0 m 2.229 0 l h f Q q 1 0 0 1 137.7634 632.205 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 138.8772 631.0917 cm 0 0 m 0 2.227 l h f Q q 1 0 0 1 138.8775 633.3183 cm 0 0 m 0 0 l 0 -2.227 l 0 0 l h S Q q 1 0 0 1 142.2207 626.0814 cm 0 0 m 2.228 0 l h f Q q 1 0 0 1 142.2205 626.0817 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 143.3349 624.9681 cm 0 0 m 0 2.227 l h f Q q 1 0 0 1 143.3346 627.195 cm 0 0 m 0 0 l 0 -2.227 l 0 0 l h S Q q 1 0 0 1 142.7778 624.9681 cm 0 0 m 2.228 0 l h f Q q 1 0 0 1 142.7777 624.9684 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 143.892 623.8548 cm 0 0 m 0 2.227 l h f Q q 1 0 0 1 143.8918 626.0817 cm 0 0 m 0 0 l 0 -2.227 l 0 0 l h S Q q 1 0 0 1 142.7778 624.9681 cm 0 0 m 2.228 0 l h f Q q 1 0 0 1 142.7777 624.9684 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 143.892 623.8548 cm 0 0 m 0 2.227 l h f Q q 1 0 0 1 143.8918 626.0817 cm 0 0 m 0 0 l 0 -2.227 l 0 0 l h S Q q 1 0 0 1 144.4491 624.9681 cm 0 0 m 2.228 0 l h f Q q 1 0 0 1 144.449 624.9684 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 145.5633 623.8548 cm 0 0 m 0 2.227 l h f Q q 1 0 0 1 145.5632 626.0817 cm 0 0 m 0 0 l 0 -2.227 l 0 0 l h S Q q 1 0 0 1 144.4491 624.9681 cm 0 0 m 2.228 0 l h f Q q 1 0 0 1 144.449 624.9684 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 145.5633 623.8548 cm 0 0 m 0 2.227 l h f Q q 1 0 0 1 145.5632 626.0817 cm 0 0 m 0 0 l 0 -2.227 l 0 0 l h S Q q 1 0 0 1 146.1204 623.2986 cm 0 0 m 2.228 0 l h f Q q 1 0 0 1 146.1204 623.2984 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 147.2346 622.1853 cm 0 0 m 0 2.227 l h f Q q 1 0 0 1 147.2348 624.4117 cm 0 0 m 0 0 l 0 -2.227 l 0 0 l h S Q q 1 0 0 1 149.463 617.7321 cm 0 0 m 2.229 0 l h f Q q 1 0 0 1 149.4633 617.7323 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 150.5772 616.6188 cm 0 0 m 0 2.227 l h f Q q 1 0 0 1 150.5775 618.8456 cm 0 0 m 0 0 l 0 -2.227 l 0 0 l h S Q q 1 0 0 1 151.6923 615.5055 cm 0 0 m 2.2 0 l h f Q q 1 0 0 1 151.6919 615.5057 cm 0 0 m 2.2 0 l 0 0 l h S Q q 1 0 0 1 152.8065 614.3922 cm 0 0 m 0 2.227 l h f Q q 1 0 0 1 152.8063 616.619 cm 0 0 m 0 0 l 0 -2.227 l 0 0 l h S Q q 1 0 0 1 152.2494 615.5055 cm 0 0 m 2.201 0 l h f Q q 1 0 0 1 152.2491 615.5057 cm 0 0 m 2.2 0 l 0 0 l h S Q q 1 0 0 1 153.3357 614.3922 cm 0 0 m 0 2.227 l h f Q q 1 0 0 1 153.3353 616.619 cm 0 0 m 0 0 l 0 -2.227 l 0 0 l h S Q q 1 0 0 1 153.8928 613.836 cm 0 0 m 2.228 0 l h f Q q 1 0 0 1 153.8925 613.8357 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 155.007 612.7227 cm 0 0 m 0 2.227 l h f Q q 1 0 0 1 155.0069 614.949 cm 0 0 m 0 0 l 0 -2.227 l 0 0 l h S Q q 1 0 0 1 156.6783 613.836 cm 0 0 m 2.228 0 l h f Q q 1 0 0 1 156.6785 613.8357 cm 0 0 m 2.228 0 l 0 0 l h S Q q 1 0 0 1 157.7925 612.7227 cm 0 0 m 0 2.227 l h f Q q 1 0 0 1 157.7929 614.949 cm 0 0 m 0 0 l 0 -2.227 l 0 0 l h S Q q 1 0 0 1 157.7925 613.836 cm 0 0 m 2.228 0 l h f Q q 1 0 0 1 157.7929 613.8357 cm 0 0 m 2.228 0 l 0 0 l h S Q q 1 0 0 1 158.9067 612.7227 cm 0 0 m 0 2.227 l h f Q q 1 0 0 1 158.9068 614.949 cm 0 0 m 0 0 l 0 -2.227 l 0 0 l h S Q q 1 0 0 1 158.9067 613.836 cm 0 0 m 2.229 0 l h f Q q 1 0 0 1 158.9068 613.8357 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 160.0209 612.7227 cm 0 0 m 0 2.227 l h f Q q 1 0 0 1 160.0212 614.949 cm 0 0 m 0 0 l 0 -2.227 l 0 0 l h S Q q 1 0 0 1 159.4638 613.836 cm 0 0 m 2.229 0 l h f Q q 1 0 0 1 159.464 613.8357 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 160.578 612.7227 cm 0 0 m 0 2.227 l h f Q q 1 0 0 1 160.5784 614.949 cm 0 0 m 0 0 l 0 -2.227 l 0 0 l h S Q q 1 0 0 1 165.5928 613.836 cm 0 0 m 2.228 0 l h f Q q 1 0 0 1 165.5927 613.8357 cm 0 0 m 2.228 0 l 0 0 l h S Q q 1 0 0 1 166.707 612.7227 cm 0 0 m 0 2.227 l h f Q q 1 0 0 1 166.7071 614.949 cm 0 0 m 0 0 l 0 -2.227 l 0 0 l h S Q q 1 0 0 1 182.8638 607.1283 cm 0 0 m 2.229 0 l h f Q q 1 0 0 1 182.8639 607.1279 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 183.978 606.015 cm 0 0 m 0 2.227 l h f Q q 1 0 0 1 183.9783 608.2413 cm 0 0 m 0 0 l 0 -2.227 l 0 0 l h S Q q 1 0 0 1 191.2212 607.1283 cm 0 0 m 2.228 0 l h f Q q 1 0 0 1 191.2209 607.1279 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 192.3354 606.015 cm 0 0 m 0 2.227 l h f Q q 1 0 0 1 192.3353 608.2413 cm 0 0 m 0 0 l 0 -2.227 l 0 0 l h S Q q 1 0 0 1 201.2499 607.1283 cm 0 0 m 2.228 0 l h f Q q 1 0 0 1 201.2496 607.1279 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 202.3641 606.015 cm 0 0 m 0 2.227 l h f Q q 1 0 0 1 202.364 608.2413 cm 0 0 m 0 0 l 0 -2.227 l 0 0 l h S Q q 1 0 0 1 202.3641 607.1283 cm 0 0 m 2.228 0 l h f Q q 1 0 0 1 202.364 607.1279 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 203.4783 606.015 cm 0 0 m 0 2.227 l h f Q q 1 0 0 1 203.4784 608.2413 cm 0 0 m 0 0 l 0 -2.227 l 0 0 l h S Q q 1 0 0 1 211.2786 607.1283 cm 0 0 m 2.228 0 l h f Q q 1 0 0 1 211.2782 607.1279 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 212.3928 606.015 cm 0 0 m 0 2.227 l h f Q q 1 0 0 1 212.3926 608.2413 cm 0 0 m 0 0 l 0 -2.227 l 0 0 l h S Q q 1 0 0 1 214.6212 607.1283 cm 0 0 m 2.228 0 l h f Q q 1 0 0 1 214.6214 607.1279 cm 0 0 m 2.228 0 l 0 0 l h S Q q 1 0 0 1 215.7354 606.015 cm 0 0 m 0 2.227 l h f Q q 1 0 0 1 215.7353 608.2413 cm 0 0 m 0 0 l 0 -2.227 l 0 0 l h S Q q 1 0 0 1 215.1783 607.1283 cm 0 0 m 2.228 0 l h f Q q 1 0 0 1 215.1781 607.1279 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 216.2925 606.015 cm 0 0 m 0 2.227 l h f Q q 1 0 0 1 216.2925 608.2413 cm 0 0 m 0 0 l 0 -2.227 l 0 0 l h S Q q 1 0 0 1 233.5356 607.1283 cm 0 0 m 2.229 0 l h f Q q 1 0 0 1 233.536 607.1279 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 234.6507 606.015 cm 0 0 m 0 2.227 l h f Q q 1 0 0 1 234.6504 608.2413 cm 0 0 m 0 0 l 0 -2.227 l 0 0 l h S Q q 1 0 0 1 236.8791 607.1283 cm 0 0 m 2.228 0 l h f Q q 1 0 0 1 236.8792 607.1279 cm 0 0 m 2.228 0 l 0 0 l h S Q q 1 0 0 1 237.9933 606.015 cm 0 0 m 0 2.227 l h f Q q 1 0 0 1 237.9931 608.2413 cm 0 0 m 0 0 l 0 -2.227 l 0 0 l h S Q q 42.52 570.362 221.102 165.49 re W n 0.557 w q 1 0 0 1 94.3062 691.5432 cm 0 0 m 0 0.464 0.372 0.835 0.836 0.835 c 1.3 0.835 1.672 0.464 1.672 0 c 1.672 -0.464 1.3 -0.835 0.836 -0.835 c 0.372 -0.835 0 -0.464 0 0 c h S Q q 1 0 0 1 95.9775 690.4298 cm 0 0 m 0 0.464 0.372 0.835 0.836 0.835 c 1.3 0.835 1.672 0.464 1.672 0 c 1.672 -0.464 1.3 -0.835 0.836 -0.835 c 0.372 -0.835 0 -0.464 0 0 c h S Q q 1 0 0 1 96.5347 688.7598 cm 0 0 m 0 0.464 0.372 0.835 0.836 0.835 c 1.3 0.835 1.672 0.464 1.672 0 c 1.672 -0.464 1.3 -0.835 0.836 -0.835 c 0.372 -0.835 0 -0.464 0 0 c h S Q q 1 0 0 1 97.0919 687.6465 cm 0 0 m 0 0.464 0.372 0.835 0.836 0.835 c 1.3 0.835 1.672 0.464 1.672 0 c 1.672 -0.464 1.3 -0.835 0.836 -0.835 c 0.372 -0.835 0 -0.464 0 0 c h S Q q 1 0 0 1 97.0919 685.9767 cm 0 0 m 0 0.464 0.372 0.835 0.836 0.835 c 1.3 0.835 1.672 0.464 1.672 0 c 1.672 -0.464 1.3 -0.835 0.836 -0.835 c 0.372 -0.835 0 -0.464 0 0 c h S Q q 1 0 0 1 97.6492 684.8635 cm 0 0 m 0 0.464 0.372 0.835 0.836 0.835 c 1.3 0.835 1.672 0.464 1.672 0 c 1.672 -0.464 1.3 -0.835 0.836 -0.835 c 0.372 -0.835 0 -0.464 0 0 c h S Q q 1 0 0 1 98.2061 683.1935 cm 0 0 m 0 0.464 0.372 0.835 0.836 0.835 c 1.3 0.835 1.672 0.464 1.672 0 c 1.672 -0.464 1.3 -0.835 0.836 -0.835 c 0.372 -0.835 0 -0.464 0 0 c h S Q q 1 0 0 1 98.7633 682.0802 cm 0 0 m 0 0.464 0.372 0.835 0.836 0.835 c 1.3 0.835 1.672 0.464 1.672 0 c 1.672 -0.464 1.3 -0.835 0.836 -0.835 c 0.372 -0.835 0 -0.464 0 0 c h S Q q 1 0 0 1 99.8777 680.9668 cm 0 0 m 0 0.464 0.372 0.835 0.836 0.835 c 1.3 0.835 1.672 0.464 1.672 0 c 1.672 -0.464 1.3 -0.835 0.836 -0.835 c 0.372 -0.835 0 -0.464 0 0 c h S Q q 1 0 0 1 100.4346 679.2971 cm 0 0 m 0 0.464 0.372 0.835 0.836 0.835 c 1.3 0.835 1.672 0.464 1.672 0 c 1.672 -0.464 1.3 -0.835 0.836 -0.835 c 0.372 -0.835 0 -0.464 0 0 c h S Q q 1 0 0 1 101.549 678.1838 cm 0 0 m 0 0.464 0.372 0.835 0.836 0.835 c 1.3 0.835 1.672 0.464 1.672 0 c 1.672 -0.464 1.3 -0.835 0.836 -0.835 c 0.372 -0.835 0 -0.464 0 0 c h S Q q 1 0 0 1 101.549 676.5138 cm 0 0 m 0 0.464 0.372 0.835 0.836 0.835 c 1.3 0.835 1.672 0.464 1.672 0 c 1.672 -0.464 1.3 -0.835 0.836 -0.835 c 0.372 -0.835 0 -0.464 0 0 c h S Q q 1 0 0 1 102.1062 675.4005 cm 0 0 m 0 0.464 0.372 0.835 0.836 0.835 c 1.3 0.835 1.672 0.464 1.672 0 c 1.672 -0.464 1.3 -0.835 0.836 -0.835 c 0.372 -0.835 0 -0.464 0 0 c h S Q q 1 0 0 1 102.6635 673.7305 cm 0 0 m 0 0.464 0.372 0.835 0.836 0.835 c 1.3 0.835 1.672 0.464 1.672 0 c 1.672 -0.464 1.3 -0.835 0.836 -0.835 c 0.372 -0.835 0 -0.464 0 0 c h S Q q 1 0 0 1 102.6635 672.6171 cm 0 0 m 0 0.464 0.372 0.835 0.836 0.835 c 1.3 0.835 1.672 0.464 1.672 0 c 1.672 -0.464 1.3 -0.835 0.836 -0.835 c 0.372 -0.835 0 -0.464 0 0 c h S Q q 1 0 0 1 103.2204 670.9471 cm 0 0 m 0 0.464 0.372 0.835 0.836 0.835 c 1.3 0.835 1.672 0.464 1.672 0 c 1.672 -0.464 1.3 -0.835 0.836 -0.835 c 0.372 -0.835 0 -0.464 0 0 c h S Q q 1 0 0 1 104.3348 669.8341 cm 0 0 m 0 0.464 0.372 0.835 0.836 0.835 c 1.3 0.835 1.672 0.464 1.672 0 c 1.672 -0.464 1.3 -0.835 0.836 -0.835 c 0.372 -0.835 0 -0.464 0 0 c h S Q q 1 0 0 1 105.4489 668.1641 cm 0 0 m 0 0.464 0.372 0.835 0.836 0.835 c 1.3 0.835 1.672 0.464 1.672 0 c 1.672 -0.464 1.3 -0.835 0.836 -0.835 c 0.372 -0.835 0 -0.464 0 0 c h S Q q 1 0 0 1 108.2347 667.0369 cm 0 0 m 0 0.471 0.372 0.849 0.836 0.849 c 1.3 0.849 1.672 0.471 1.672 0 c 1.672 -0.472 1.3 -0.849 0.836 -0.849 c 0.372 -0.849 0 -0.472 0 0 c h S Q q 1 0 0 1 108.2347 665.9097 cm 0 0 m 0 0.464 0.372 0.835 0.836 0.835 c 1.3 0.835 1.672 0.464 1.672 0 c 1.672 -0.464 1.3 -0.835 0.836 -0.835 c 0.372 -0.835 0 -0.464 0 0 c h S Q q 1 0 0 1 108.2347 664.2397 cm 0 0 m 0 0.464 0.372 0.835 0.836 0.835 c 1.3 0.835 1.672 0.464 1.672 0 c 1.672 -0.464 1.3 -0.835 0.836 -0.835 c 0.372 -0.835 0 -0.464 0 0 c h S Q q 1 0 0 1 109.9063 663.1264 cm 0 0 m 0 0.464 0.372 0.835 0.836 0.835 c 1.3 0.835 1.672 0.464 1.672 0 c 1.672 -0.464 1.3 -0.835 0.836 -0.835 c 0.372 -0.835 0 -0.464 0 0 c h S Q q 1 0 0 1 110.4632 661.4564 cm 0 0 m 0 0.464 0.372 0.835 0.836 0.835 c 1.3 0.835 1.672 0.464 1.672 0 c 1.672 -0.464 1.3 -0.835 0.836 -0.835 c 0.372 -0.835 0 -0.464 0 0 c h S Q q 1 0 0 1 112.1349 660.3431 cm 0 0 m 0 0.464 0.372 0.835 0.836 0.835 c 1.3 0.835 1.672 0.464 1.672 0 c 1.672 -0.464 1.3 -0.835 0.836 -0.835 c 0.372 -0.835 0 -0.464 0 0 c h S Q q 1 0 0 1 112.1349 658.6733 cm 0 0 m 0 0.464 0.372 0.835 0.836 0.835 c 1.3 0.835 1.672 0.464 1.672 0 c 1.672 -0.464 1.3 -0.835 0.836 -0.835 c 0.372 -0.835 0 -0.464 0 0 c h S Q q 1 0 0 1 112.6918 657.5601 cm 0 0 m 0 0.464 0.372 0.835 0.836 0.835 c 1.3 0.835 1.672 0.464 1.672 0 c 1.672 -0.464 1.3 -0.835 0.836 -0.835 c 0.372 -0.835 0 -0.464 0 0 c h S Q q 1 0 0 1 113.249 655.8901 cm 0 0 m 0 0.464 0.372 0.835 0.836 0.835 c 1.3 0.835 1.672 0.464 1.672 0 c 1.672 -0.464 1.3 -0.835 0.836 -0.835 c 0.372 -0.835 0 -0.464 0 0 c h S Q q 1 0 0 1 113.8062 654.7767 cm 0 0 m 0 0.464 0.372 0.835 0.836 0.835 c 1.3 0.835 1.672 0.464 1.672 0 c 1.672 -0.464 1.3 -0.835 0.836 -0.835 c 0.372 -0.835 0 -0.464 0 0 c h S Q q 1 0 0 1 114.3634 653.1068 cm 0 0 m 0 0.464 0.372 0.835 0.836 0.835 c 1.3 0.835 1.672 0.464 1.672 0 c 1.672 -0.464 1.3 -0.835 0.836 -0.835 c 0.372 -0.835 0 -0.464 0 0 c h S Q q 1 0 0 1 115.4776 651.9935 cm 0 0 m 0 0.464 0.372 0.835 0.836 0.835 c 1.3 0.835 1.672 0.464 1.672 0 c 1.672 -0.464 1.3 -0.835 0.836 -0.835 c 0.372 -0.835 0 -0.464 0 0 c h S Q q 1 0 0 1 116.0348 650.3235 cm 0 0 m 0 0.464 0.372 0.835 0.836 0.835 c 1.3 0.835 1.672 0.464 1.672 0 c 1.672 -0.464 1.3 -0.835 0.836 -0.835 c 0.372 -0.835 0 -0.464 0 0 c h S Q q 1 0 0 1 117.7061 649.2101 cm 0 0 m 0 0.464 0.372 0.835 0.836 0.835 c 1.3 0.835 1.672 0.464 1.672 0 c 1.672 -0.464 1.3 -0.835 0.836 -0.835 c 0.372 -0.835 0 -0.464 0 0 c h S Q q 1 0 0 1 118.2634 648.0968 cm 0 0 m 0 0.464 0.372 0.835 0.836 0.835 c 1.3 0.835 1.672 0.464 1.672 0 c 1.672 -0.464 1.3 -0.835 0.836 -0.835 c 0.372 -0.835 0 -0.464 0 0 c h S Q q 1 0 0 1 119.3778 646.4274 cm 0 0 m 0 0.464 0.372 0.835 0.836 0.835 c 1.3 0.835 1.672 0.464 1.672 0 c 1.672 -0.464 1.3 -0.835 0.836 -0.835 c 0.372 -0.835 0 -0.464 0 0 c h S Q q 1 0 0 1 119.9347 645.314 cm 0 0 m 0 0.464 0.372 0.835 0.836 0.835 c 1.3 0.835 1.672 0.464 1.672 0 c 1.672 -0.464 1.3 -0.835 0.836 -0.835 c 0.372 -0.835 0 -0.464 0 0 c h S Q q 1 0 0 1 121.0491 643.644 cm 0 0 m 0 0.464 0.372 0.835 0.836 0.835 c 1.3 0.835 1.672 0.464 1.672 0 c 1.672 -0.464 1.3 -0.835 0.836 -0.835 c 0.372 -0.835 0 -0.464 0 0 c h S Q q 1 0 0 1 124.3918 642.5307 cm 0 0 m 0 0.464 0.372 0.835 0.836 0.835 c 1.3 0.835 1.672 0.464 1.672 0 c 1.672 -0.464 1.3 -0.835 0.836 -0.835 c 0.372 -0.835 0 -0.464 0 0 c h S Q q 1 0 0 1 127.7347 640.8607 cm 0 0 m 0 0.464 0.372 0.835 0.836 0.835 c 1.3 0.835 1.672 0.464 1.672 0 c 1.672 -0.464 1.3 -0.835 0.836 -0.835 c 0.372 -0.835 0 -0.464 0 0 c h S Q q 1 0 0 1 128.8492 639.7332 cm 0 0 m 0 0.472 0.372 0.849 0.836 0.849 c 1.3 0.849 1.672 0.472 1.672 0 c 1.672 -0.471 1.3 -0.849 0.836 -0.849 c 0.372 -0.849 0 -0.471 0 0 c h S Q q 1 0 0 1 132.749 638.0496 cm 0 0 m 0 0.464 0.372 0.835 0.836 0.835 c 1.3 0.835 1.672 0.464 1.672 0 c 1.672 -0.464 1.3 -0.835 0.836 -0.835 c 0.372 -0.835 0 -0.464 0 0 c h S Q q 1 0 0 1 133.3062 636.9363 cm 0 0 m 0 0.464 0.372 0.835 0.836 0.835 c 1.3 0.835 1.672 0.464 1.672 0 c 1.672 -0.464 1.3 -0.835 0.836 -0.835 c 0.372 -0.835 0 -0.464 0 0 c h S Q q 1 0 0 1 133.8632 635.2664 cm 0 0 m 0 0.464 0.372 0.835 0.836 0.835 c 1.3 0.835 1.672 0.464 1.672 0 c 1.672 -0.464 1.3 -0.835 0.836 -0.835 c 0.372 -0.835 0 -0.464 0 0 c h S Q q 1 0 0 1 134.9776 634.153 cm 0 0 m 0 0.464 0.372 0.835 0.836 0.835 c 1.3 0.835 1.672 0.464 1.672 0 c 1.672 -0.464 1.3 -0.835 0.836 -0.835 c 0.372 -0.835 0 -0.464 0 0 c h S Q q 1 0 0 1 135.5349 632.483 cm 0 0 m 0 0.464 0.372 0.835 0.836 0.835 c 1.3 0.835 1.672 0.464 1.672 0 c 1.672 -0.464 1.3 -0.835 0.836 -0.835 c 0.372 -0.835 0 -0.464 0 0 c h S Q q 1 0 0 1 137.7634 630.813 cm 0 0 m 0 0.464 0.372 0.835 0.836 0.835 c 1.3 0.835 1.672 0.464 1.672 0 c 1.672 -0.464 1.3 -0.835 0.836 -0.835 c 0.372 -0.835 0 -0.464 0 0 c h S Q q 1 0 0 1 138.8775 629.6997 cm 0 0 m 0 0.464 0.372 0.835 0.836 0.835 c 1.3 0.835 1.672 0.464 1.672 0 c 1.672 -0.464 1.3 -0.835 0.836 -0.835 c 0.372 -0.835 0 -0.464 0 0 c h S Q q 1 0 0 1 139.9919 628.0303 cm 0 0 m 0 0.464 0.372 0.835 0.836 0.835 c 1.3 0.835 1.672 0.464 1.672 0 c 1.672 -0.464 1.3 -0.835 0.836 -0.835 c 0.372 -0.835 0 -0.464 0 0 c h S Q q 1 0 0 1 142.2205 626.3603 cm 0 0 m 0 0.464 0.372 0.835 0.836 0.835 c 1.3 0.835 1.672 0.464 1.672 0 c 1.672 -0.464 1.3 -0.835 0.836 -0.835 c 0.372 -0.835 0 -0.464 0 0 c h S Q q 1 0 0 1 142.7777 625.247 cm 0 0 m 0 0.464 0.372 0.835 0.836 0.835 c 1.3 0.835 1.672 0.464 1.672 0 c 1.672 -0.464 1.3 -0.835 0.836 -0.835 c 0.372 -0.835 0 -0.464 0 0 c h S Q q 1 0 0 1 145.5632 623.577 cm 0 0 m 0 0.464 0.372 0.835 0.836 0.835 c 1.3 0.835 1.672 0.464 1.672 0 c 1.672 -0.464 1.3 -0.835 0.836 -0.835 c 0.372 -0.835 0 -0.464 0 0 c h S Q q 1 0 0 1 146.6776 621.3503 cm 0 0 m 0 0.464 0.372 0.835 0.836 0.835 c 1.3 0.835 1.672 0.464 1.672 0 c 1.672 -0.464 1.3 -0.835 0.836 -0.835 c 0.372 -0.835 0 -0.464 0 0 c h S Q q 1 0 0 1 147.2348 619.6803 cm 0 0 m 0 0.464 0.372 0.835 0.836 0.835 c 1.3 0.835 1.672 0.464 1.672 0 c 1.672 -0.464 1.3 -0.835 0.836 -0.835 c 0.372 -0.835 0 -0.464 0 0 c h S Q q 1 0 0 1 148.3489 618.0104 cm 0 0 m 0 0.464 0.372 0.835 0.836 0.835 c 1.3 0.835 1.672 0.464 1.672 0 c 1.672 -0.464 1.3 -0.835 0.836 -0.835 c 0.372 -0.835 0 -0.464 0 0 c h S Q q 1 0 0 1 150.5775 615.7837 cm 0 0 m 0 0.464 0.372 0.835 0.836 0.835 c 1.3 0.835 1.672 0.464 1.672 0 c 1.672 -0.464 1.3 -0.835 0.836 -0.835 c 0.372 -0.835 0 -0.464 0 0 c h S Q q 1 0 0 1 152.8063 614.1137 cm 0 0 m 0 0.464 0.365 0.835 0.822 0.835 c 1.278 0.835 1.643 0.464 1.643 0 c 1.643 -0.464 1.278 -0.835 0.822 -0.835 c 0.365 -0.835 0 -0.464 0 0 c h S Q q 1 0 0 1 166.7071 610.746 cm 0 0 m 0 0.464 0.371 0.835 0.835 0.835 c 1.3 0.835 1.671 0.464 1.671 0 c 1.671 -0.464 1.3 -0.835 0.835 -0.835 c 0.371 -0.835 0 -0.464 0 0 c h S Q q 1 0 0 1 167.2643 607.4066 cm 0 0 m 0 0.464 0.371 0.835 0.835 0.835 c 1.3 0.835 1.671 0.464 1.671 0 c 1.671 -0.464 1.3 -0.835 0.835 -0.835 c 0.371 -0.835 0 -0.464 0 0 c h S Q Q 0 0 0 1 K 0.557 w /GS1 gs q 1 0 0 1 62.577 589.3153 cm 0 0 m 194.916 0 l S Q q 1 0 0 1 62.577 590.4286 cm 0 0 m 0 -1.113 l S Q q 1 0 0 1 95.0585 590.4286 cm 0 0 m 0 -1.113 l S Q q 1 0 0 1 127.5397 590.4286 cm 0 0 m 0 -1.113 l S Q q 1 0 0 1 160.0212 590.4286 cm 0 0 m 0 -1.113 l S Q q 1 0 0 1 192.5024 590.4286 cm 0 0 m 0 -1.113 l S Q q 1 0 0 1 224.9842 590.4286 cm 0 0 m 0 -1.113 l S Q q 1 0 0 1 257.4932 590.4286 cm 0 0 m 0 -1.113 l S Q q 1 0 0 1 69.0675 589.8719 cm 0 0 m 0 -0.557 l S Q q 1 0 0 1 75.5584 589.8719 cm 0 0 m 0 -0.557 l S Q q 1 0 0 1 82.049 589.8719 cm 0 0 m 0 -0.557 l S Q q 1 0 0 1 88.5398 589.8719 cm 0 0 m 0 -0.557 l S Q q 1 0 0 1 95.0585 589.8719 cm 0 0 m 0 -0.557 l S Q q 1 0 0 1 101.549 589.8719 cm 0 0 m 0 -0.557 l S Q q 1 0 0 1 108.0399 589.8719 cm 0 0 m 0 -0.557 l S Q q 1 0 0 1 114.5305 589.8719 cm 0 0 m 0 -0.557 l S Q q 1 0 0 1 121.0491 589.8719 cm 0 0 m 0 -0.557 l S Q q 1 0 0 1 127.5397 589.8719 cm 0 0 m 0 -0.557 l S Q q 1 0 0 1 134.0305 589.8719 cm 0 0 m 0 -0.557 l S Q q 1 0 0 1 140.5211 589.8719 cm 0 0 m 0 -0.557 l S Q q 1 0 0 1 147.0397 589.8719 cm 0 0 m 0 -0.557 l S Q q 1 0 0 1 153.5306 589.8719 cm 0 0 m 0 -0.557 l S Q q 1 0 0 1 160.0212 589.8719 cm 0 0 m 0 -0.557 l S Q q 1 0 0 1 166.5117 589.8719 cm 0 0 m 0 -0.557 l S Q q 1 0 0 1 173.0029 589.8719 cm 0 0 m 0 -0.557 l S Q q 1 0 0 1 179.5213 589.8719 cm 0 0 m 0 -0.557 l S Q q 1 0 0 1 186.0118 589.8719 cm 0 0 m 0 -0.557 l S Q q 1 0 0 1 192.5024 589.8719 cm 0 0 m 0 -0.557 l S Q q 1 0 0 1 198.9935 589.8719 cm 0 0 m 0 -0.557 l S Q q 1 0 0 1 205.5119 589.8719 cm 0 0 m 0 -0.557 l S Q q 1 0 0 1 212.0024 589.8719 cm 0 0 m 0 -0.557 l S Q q 1 0 0 1 218.4936 589.8719 cm 0 0 m 0 -0.557 l S Q q 1 0 0 1 224.9842 589.8719 cm 0 0 m 0 -0.557 l S Q q 1 0 0 1 231.5025 589.8719 cm 0 0 m 0 -0.557 l S Q q 1 0 0 1 237.9931 589.8719 cm 0 0 m 0 -0.557 l S Q q 1 0 0 1 244.4843 589.8719 cm 0 0 m 0 -0.557 l S Q q 1 0 0 1 250.9748 589.8719 cm 0 0 m 0 -0.557 l S Q q 1 0 0 1 257.4932 589.8719 cm 0 0 m 0 -0.557 l S Q BT 0 0 0 1 k /TT0 1 Tf 4.495 0 0 4.648 59.5123 582.89 Tm (-)Tj 0.371 0 Td (2)Tj 0.496 0 Td (0)Tj 6.793 0 Td (0)Tj 6.978 0 Td (2)Tj 0.496 0 Td (0)Tj 6.729 0 Td (4)Tj 0.496 0 Td (0)Tj 6.73 0 Td (6)Tj 0.496 0 Td (0)Tj 6.73 0 Td (8)Tj 0.496 0 Td (0)Tj 6.488 0 Td (1)Tj 0.496 0 Td (0)Tj 0.496 0 Td (0)Tj /C2_0 1 Tf -30.052 -1.858 Td <023C>Tj 0.62 0 Td <026A>Tj 0.496 0 Td <025F>Tj 0.496 0 Td <0266>Tj 0.744 0 Td <0279>Tj /TT0 1 Tf 0.496 0 Td ( )Tj /C2_0 1 Tf 0.249 0 Td <0268>Tj 0.496 0 Td <026C>Tj /TT0 1 Tf 0.495 0 Td ( )Tj /C2_0 1 Tf 0.249 0 Td <0269>Tj 0.497 0 Td <026A>Tj 0.496 0 Td <0268>Tj 0.496 0 Td <025C>Tj 0.496 0 Td <025F>Tj 0.496 0 Td <025E>Tj 0.62 0 Td <025F>Tj 0.496 0 Td <0267>Tj 0.49 0 Td <0262>Tj 0.497 0 Td <0279>Tj /TT0 1 Tf 0.497 0 Td ( )Tj /C2_0 1 Tf 0.249 0 Td <0268>Tj 0.496 0 Td <0269>Tj 0.496 0 Td <025F>Tj 0.496 0 Td <026A>Tj 0.496 0 Td <025A>Tj 0.496 0 Td <0270>Tj 0.619 0 Td <0262>Tj 0.497 0 Td <0262>Tj /TT0 1 Tf 0.497 0 Td (,)Tj 0.249 0 Td ( )Tj /C2_0 1 Tf 0.249 0 Td <0266>Tj 0.744 0 Td <025F>Tj 0.496 0 Td <026B>Tj /TT0 1 Tf 0.496 0 Td (.)Tj ET q 1 0 0 1 62.577 715.7849 cm 0 0 m 194.916 0 l S Q q 1 0 0 1 71.8533 714.6438 cm 0 0 m 0 1.141 l S Q q 1 0 0 1 108.9589 714.6438 cm 0 0 m 0 1.141 l S Q q 1 0 0 1 146.0927 714.6438 cm 0 0 m 0 1.141 l S Q q 1 0 0 1 183.2263 714.6438 cm 0 0 m 0 1.141 l S Q q 1 0 0 1 220.36 714.6438 cm 0 0 m 0 1.141 l S Q q 1 0 0 1 257.4932 714.6438 cm 0 0 m 0 1.141 l S Q q 1 0 0 1 64.4153 715.2004 cm 0 0 m 0 0.585 l S Q q 1 0 0 1 71.8533 715.2004 cm 0 0 m 0 0.585 l S Q q 1 0 0 1 79.2632 715.2004 cm 0 0 m 0 0.585 l S Q q 1 0 0 1 86.7012 715.2004 cm 0 0 m 0 0.585 l S Q q 1 0 0 1 94.1111 715.2004 cm 0 0 m 0 0.585 l S Q q 1 0 0 1 101.549 715.2004 cm 0 0 m 0 0.585 l S Q q 1 0 0 1 108.9589 715.2004 cm 0 0 m 0 0.585 l S Q q 1 0 0 1 116.3969 715.2004 cm 0 0 m 0 0.585 l S Q q 1 0 0 1 123.8349 715.2004 cm 0 0 m 0 0.585 l S Q q 1 0 0 1 131.2448 715.2004 cm 0 0 m 0 0.585 l S Q q 1 0 0 1 138.6827 715.2004 cm 0 0 m 0 0.585 l S Q q 1 0 0 1 146.0927 715.2004 cm 0 0 m 0 0.585 l S Q q 1 0 0 1 153.5306 715.2004 cm 0 0 m 0 0.585 l S Q q 1 0 0 1 160.9402 715.2004 cm 0 0 m 0 0.585 l S Q q 1 0 0 1 168.3782 715.2004 cm 0 0 m 0 0.585 l S Q q 1 0 0 1 175.7884 715.2004 cm 0 0 m 0 0.585 l S Q q 1 0 0 1 183.2263 715.2004 cm 0 0 m 0 0.585 l S Q q 1 0 0 1 190.6643 715.2004 cm 0 0 m 0 0.585 l S Q q 1 0 0 1 198.0739 715.2004 cm 0 0 m 0 0.585 l S Q q 1 0 0 1 205.5119 715.2004 cm 0 0 m 0 0.585 l S Q q 1 0 0 1 212.9221 715.2004 cm 0 0 m 0 0.585 l S Q q 1 0 0 1 220.36 715.2004 cm 0 0 m 0 0.585 l S Q q 1 0 0 1 227.7697 715.2004 cm 0 0 m 0 0.585 l S Q q 1 0 0 1 235.2076 715.2004 cm 0 0 m 0 0.585 l S Q q 1 0 0 1 242.6178 715.2004 cm 0 0 m 0 0.585 l S Q q 1 0 0 1 250.0552 715.2004 cm 0 0 m 0 0.585 l S Q q 1 0 0 1 257.4932 715.2004 cm 0 0 m 0 0.585 l S Q q 1 0 0 1 62.577 589.3153 cm 0 0 m 0 126.47 l S Q q 1 0 0 1 63.6633 589.3153 cm 0 0 m -1.087 0 l S Q q 1 0 0 1 63.6633 600.8099 cm 0 0 m -1.087 0 l S Q q 1 0 0 1 63.6633 612.305 cm 0 0 m -1.087 0 l S Q q 1 0 0 1 63.6633 623.7995 cm 0 0 m -1.087 0 l S Q q 1 0 0 1 63.6633 635.2941 cm 0 0 m -1.087 0 l S Q q 1 0 0 1 63.6633 646.7892 cm 0 0 m -1.087 0 l S Q q 1 0 0 1 63.6633 658.2838 cm 0 0 m -1.087 0 l S Q q 1 0 0 1 63.6633 669.7783 cm 0 0 m -1.087 0 l S Q q 1 0 0 1 63.6633 681.2729 cm 0 0 m -1.087 0 l S Q q 1 0 0 1 63.6633 692.7677 cm 0 0 m -1.087 0 l S Q q 1 0 0 1 63.6633 704.2626 cm 0 0 m -1.087 0 l S Q q 1 0 0 1 63.6633 715.7571 cm 0 0 m -1.087 0 l S Q q 1 0 0 1 63.1061 592.1819 cm 0 0 m -0.529 0 l S Q q 1 0 0 1 63.1061 595.049 cm 0 0 m -0.529 0 l S Q q 1 0 0 1 63.1061 597.9155 cm 0 0 m -0.529 0 l S Q q 1 0 0 1 63.1061 600.8099 cm 0 0 m -0.529 0 l S Q q 1 0 0 1 63.1061 603.6769 cm 0 0 m -0.529 0 l S Q q 1 0 0 1 63.1061 606.5436 cm 0 0 m -0.529 0 l S Q q 1 0 0 1 63.1061 609.4101 cm 0 0 m -0.529 0 l S Q q 1 0 0 1 63.1061 612.305 cm 0 0 m -0.529 0 l S Q q 1 0 0 1 63.1061 615.1715 cm 0 0 m -0.529 0 l S Q q 1 0 0 1 63.1061 618.0381 cm 0 0 m -0.529 0 l S Q q 1 0 0 1 63.1061 620.9052 cm 0 0 m -0.529 0 l S Q q 1 0 0 1 63.1061 623.7995 cm 0 0 m -0.529 0 l S Q q 1 0 0 1 63.1061 626.6661 cm 0 0 m -0.529 0 l S Q q 1 0 0 1 63.1061 629.5333 cm 0 0 m -0.529 0 l S Q q 1 0 0 1 63.1061 632.4276 cm 0 0 m -0.529 0 l S Q q 1 0 0 1 63.1061 635.2941 cm 0 0 m -0.529 0 l S Q q 1 0 0 1 63.1061 638.1612 cm 0 0 m -0.529 0 l S Q q 1 0 0 1 63.1061 641.0278 cm 0 0 m -0.529 0 l S Q q 1 0 0 1 63.1061 643.9221 cm 0 0 m -0.529 0 l S Q q 1 0 0 1 63.1061 646.7892 cm 0 0 m -0.529 0 l S Q q 1 0 0 1 63.1061 649.6558 cm 0 0 m -0.529 0 l S Q q 1 0 0 1 63.1061 652.5223 cm 0 0 m -0.529 0 l S Q q 1 0 0 1 63.1061 655.4169 cm 0 0 m -0.529 0 l S Q q 1 0 0 1 63.1061 658.2838 cm 0 0 m -0.529 0 l S Q q 1 0 0 1 63.1061 661.1503 cm 0 0 m -0.529 0 l S Q q 1 0 0 1 63.1061 664.0449 cm 0 0 m -0.529 0 l S Q q 1 0 0 1 63.1061 666.9117 cm 0 0 m -0.529 0 l S Q q 1 0 0 1 63.1061 669.7783 cm 0 0 m -0.529 0 l S Q q 1 0 0 1 63.1061 672.6451 cm 0 0 m -0.529 0 l S Q q 1 0 0 1 63.1061 675.5395 cm 0 0 m -0.529 0 l S Q q 1 0 0 1 63.1061 678.4063 cm 0 0 m -0.529 0 l S Q q 1 0 0 1 63.1061 681.2729 cm 0 0 m -0.529 0 l S Q q 1 0 0 1 63.1061 684.1397 cm 0 0 m -0.529 0 l S Q q 1 0 0 1 63.1061 687.0344 cm 0 0 m -0.529 0 l S Q q 1 0 0 1 63.1061 689.9009 cm 0 0 m -0.529 0 l S Q q 1 0 0 1 63.1061 692.7677 cm 0 0 m -0.529 0 l S Q q 1 0 0 1 63.1061 695.6623 cm 0 0 m -0.529 0 l S Q q 1 0 0 1 63.1061 698.5289 cm 0 0 m -0.529 0 l S Q q 1 0 0 1 63.1061 701.3958 cm 0 0 m -0.529 0 l S Q q 1 0 0 1 63.1061 704.2626 cm 0 0 m -0.529 0 l S Q q 1 0 0 1 63.1061 707.1569 cm 0 0 m -0.529 0 l S Q q 1 0 0 1 63.1061 710.0237 cm 0 0 m -0.529 0 l S Q q 1 0 0 1 63.1061 712.8906 cm 0 0 m -0.529 0 l S Q q 1 0 0 1 63.1061 715.7571 cm 0 0 m -0.529 0 l S Q BT /TT0 1 Tf 4.495 0 0 4.648 54.7761 587.9223 Tm (0)Tj 0.496 0 Td (,)Tj 0.249 0 Td (1)Tj -0.745 2.474 Td (0)Tj 0.496 0 Td (,)Tj 0.249 0 Td (2)Tj -0.745 2.473 Td (0)Tj 0.496 0 Td (,)Tj 0.249 0 Td (3)Tj -0.745 2.473 Td (0)Tj 0.496 0 Td (,)Tj 0.249 0 Td (4)Tj -0.745 2.473 Td (0)Tj 0.496 0 Td (,)Tj 0.249 0 Td (5)Tj -0.745 2.473 Td (0)Tj 0.496 0 Td (,)Tj 0.249 0 Td (6)Tj -0.745 2.474 Td (0)Tj 0.496 0 Td (,)Tj 0.249 0 Td (7)Tj -0.745 2.473 Td (0)Tj 0.496 0 Td (,)Tj 0.249 0 Td (8)Tj -0.745 2.473 Td (0)Tj 0.496 0 Td (,)Tj 0.249 0 Td (9)Tj -0.745 2.473 Td (1)Tj 0.496 0 Td (,)Tj 0.249 0 Td (0)Tj -0.745 2.474 Td (1)Tj 0.496 0 Td (,)Tj 0.249 0 Td (1)Tj -0.745 2.473 Td (1)Tj 0.496 0 Td (,)Tj 0.249 0 Td (2)Tj /C2_0 1 Tf 0 4.648 -4.6521 0 49.7614 618.5645 Tm <0244>Tj 0.598 0 Td <026D>Tj 0.48 0 Td <0266>Tj 0.719 0 Td <026D>Tj 0.48 0 Td <0265>Tj 0.598 0 Td <0279>Tj 0.604 0 Td <026C>Tj 0.479 0 Td <0262>Tj 0.599 0 Td <025C>Tj 0.479 0 Td <0267>Tj 0.598 0 Td <025A>Tj 0.598 0 Td <0279>Tj /TT0 1 Tf 0.598 0 Td ( )Tj /C2_0 1 Tf 0.24 0 Td <025E>Tj 0.598 0 Td <0268>Tj 0.598 0 Td <0265>Tj 0.598 0 Td <0279>Tj /TT0 1 Tf 0.604 0 Td ( )Tj /C2_0 1 Tf 0.24 0 Td <025C>Tj 0.479 0 Td <0275>Tj <0260>Tj 1.437 0 Td <0262>Tj 0.599 0 Td <025C>Tj 0.479 0 Td <0272>Tj 0.838 0 Td <0262>Tj 0.599 0 Td <026F>Tj ET q 1 0 0 1 257.4932 589.3153 cm 0 0 m 0 126.47 l S Q q 1 0 0 1 256.3793 589.3153 cm 0 0 m 1.114 0 l S Q q 1 0 0 1 256.3793 600.8099 cm 0 0 m 1.114 0 l S Q q 1 0 0 1 256.3793 612.305 cm 0 0 m 1.114 0 l S Q q 1 0 0 1 256.3793 623.7995 cm 0 0 m 1.114 0 l S Q q 1 0 0 1 256.3793 635.2941 cm 0 0 m 1.114 0 l S Q q 1 0 0 1 256.3793 646.7892 cm 0 0 m 1.114 0 l S Q q 1 0 0 1 256.3793 658.2838 cm 0 0 m 1.114 0 l S Q q 1 0 0 1 256.3793 669.7783 cm 0 0 m 1.114 0 l S Q q 1 0 0 1 256.3793 681.2729 cm 0 0 m 1.114 0 l S Q q 1 0 0 1 256.3793 692.7677 cm 0 0 m 1.114 0 l S Q q 1 0 0 1 256.3793 704.2626 cm 0 0 m 1.114 0 l S Q q 1 0 0 1 256.3793 715.7571 cm 0 0 m 1.114 0 l S Q q 1 0 0 1 256.936 592.1819 cm 0 0 m 0.557 0 l S Q q 1 0 0 1 256.936 595.049 cm 0 0 m 0.557 0 l S Q q 1 0 0 1 256.936 597.9155 cm 0 0 m 0.557 0 l S Q q 1 0 0 1 256.936 600.8099 cm 0 0 m 0.557 0 l S Q q 1 0 0 1 256.936 603.6769 cm 0 0 m 0.557 0 l S Q q 1 0 0 1 256.936 606.5436 cm 0 0 m 0.557 0 l S Q q 1 0 0 1 256.936 609.4101 cm 0 0 m 0.557 0 l S Q q 1 0 0 1 256.936 612.305 cm 0 0 m 0.557 0 l S Q q 1 0 0 1 256.936 615.1715 cm 0 0 m 0.557 0 l S Q q 1 0 0 1 256.936 618.0381 cm 0 0 m 0.557 0 l S Q q 1 0 0 1 256.936 620.9052 cm 0 0 m 0.557 0 l S Q q 1 0 0 1 256.936 623.7995 cm 0 0 m 0.557 0 l S Q q 1 0 0 1 256.936 626.6661 cm 0 0 m 0.557 0 l S Q q 1 0 0 1 256.936 629.5333 cm 0 0 m 0.557 0 l S Q q 1 0 0 1 256.936 632.4276 cm 0 0 m 0.557 0 l S Q q 1 0 0 1 256.936 635.2941 cm 0 0 m 0.557 0 l S Q q 1 0 0 1 256.936 638.1612 cm 0 0 m 0.557 0 l S Q q 1 0 0 1 256.936 641.0278 cm 0 0 m 0.557 0 l S Q q 1 0 0 1 256.936 643.9221 cm 0 0 m 0.557 0 l S Q q 1 0 0 1 256.936 646.7892 cm 0 0 m 0.557 0 l S Q q 1 0 0 1 256.936 649.6558 cm 0 0 m 0.557 0 l S Q q 1 0 0 1 256.936 652.5223 cm 0 0 m 0.557 0 l S Q q 1 0 0 1 256.936 655.4169 cm 0 0 m 0.557 0 l S Q q 1 0 0 1 256.936 658.2838 cm 0 0 m 0.557 0 l S Q q 1 0 0 1 256.936 661.1503 cm 0 0 m 0.557 0 l S Q q 1 0 0 1 256.936 664.0449 cm 0 0 m 0.557 0 l S Q q 1 0 0 1 256.936 666.9117 cm 0 0 m 0.557 0 l S Q q 1 0 0 1 256.936 669.7783 cm 0 0 m 0.557 0 l S Q q 1 0 0 1 256.936 672.6451 cm 0 0 m 0.557 0 l S Q q 1 0 0 1 256.936 675.5395 cm 0 0 m 0.557 0 l S Q q 1 0 0 1 256.936 678.4063 cm 0 0 m 0.557 0 l S Q q 1 0 0 1 256.936 681.2729 cm 0 0 m 0.557 0 l S Q q 1 0 0 1 256.936 684.1397 cm 0 0 m 0.557 0 l S Q q 1 0 0 1 256.936 687.0344 cm 0 0 m 0.557 0 l S Q q 1 0 0 1 256.936 689.9009 cm 0 0 m 0.557 0 l S Q q 1 0 0 1 256.936 692.7677 cm 0 0 m 0.557 0 l S Q q 1 0 0 1 256.936 695.6623 cm 0 0 m 0.557 0 l S Q q 1 0 0 1 256.936 698.5289 cm 0 0 m 0.557 0 l S Q q 1 0 0 1 256.936 701.3958 cm 0 0 m 0.557 0 l S Q q 1 0 0 1 256.936 704.2626 cm 0 0 m 0.557 0 l S Q q 1 0 0 1 256.936 707.1569 cm 0 0 m 0.557 0 l S Q q 1 0 0 1 256.936 710.0237 cm 0 0 m 0.557 0 l S Q q 1 0 0 1 256.936 712.8906 cm 0 0 m 0.557 0 l S Q q 1 0 0 1 256.936 715.7571 cm 0 0 m 0.557 0 l S Q EMC BT 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0.066 Tw 9 0 0 9 42.5197 559.4147 Tm [(\022\t\217\210\b\002\220 )0.6(1.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf [( )0.5(\255\005\211\026\002 )0.6(\027\020\204\025\027\026\031\003\n\t\024\022 )0.5(\005\n\023\022\021\020\004 )0.6(\003\031\024\026\t\024\026\024\025\006\031)]TJ 0 Tw (-)Tj 0 -1.2 TD (\t\013\025\003 \032\026\013\n\003 \033\032\002\003\n\017 \013\025\001\013\ \025)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0.181 Tw T* [(F)-16(igure 1)47(.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf [( Ov)13(erall sur)-42(viv)16(al of patients with metastatic rectal )]TJ 0 Tw T* (cancer)Tj ET 0 0 0 0 k /GS0 gs 42.52 351.021 221.102 165.49 re f /PlacedPDF /MC1 BDC 0 0.008 0.049 0 k 42.52 351.021 221.102 165.49 re f BT 0 0 0 1 k /GS1 gs /C2_1 1 Tf 4.495 0 0 4.648 129.4069 508.1613 Tm <024E>Tj 0.744 0 Td <026D>Tj 0.372 0 Td <0267>Tj 0.496 0 Td <0264>Tj 0.496 0 Td <0270>Tj 0.619 0 Td <0262>Tj 0.497 0 Td <0279>Tj /TT1 1 Tf 0.497 0 Td ( )Tj /C2_1 1 Tf 0.249 0 Td <023C>Tj 0.62 0 Td <0275>Tj 0.743 0 Td <0260>Tj 0.62 0 Td <0262>Tj 0.497 0 Td <025C>Tj 0.496 0 Td <025A>Tj 0.496 0 Td <025F>Tj 0.496 0 Td <0266>Tj 0.737 0 Td <0268>Tj 0.496 0 Td <026B>Tj 0.496 0 Td <026C>Tj 0.495 0 Td <0262>Tj ET q 42.52 351.021 221.102 165.49 re W n 0 0.994 1 0 K /GS0 gs q 1 0 0 1 128.292 502.8592 cm 0 0 m 0 0.471 0.372 0.849 0.836 0.849 c 1.3 0.849 1.672 0.471 1.672 0 c 1.672 -0.472 1.3 -0.849 0.836 -0.849 c 0.372 -0.849 0 -0.472 0 0 c h S Q Q BT /C2_1 1 Tf 4.495 0 0 4.648 133.8341 500.8959 Tm <0241>Tj 0.619 0 Td <025A>Tj 0.496 0 Td <025C>Tj 0.496 0 Td <025F>Tj 0.496 0 Td <026A>Tj 0.496 0 Td <0272>Tj /TT1 1 Tf 0.744 0 Td (.)Tj 0.249 0 Td ( )Tj 0.249 0 Td ( )Tj 0.249 0 Td ( )Tj ET 0 0.994 1 0 k /GS0 gs q 1 0 0 1 156.6783 502.5672 cm 0 0 m 2.228 0 l h f Q 0 0.994 1 0 K 0.279 w q 1 0 0 1 156.6785 502.567 cm 0 0 m 2.228 0 l 0 0 l h S Q q 1 0 0 1 157.7925 501.4539 cm 0 0 m 0 2.255 l h f Q q 1 0 0 1 157.7929 503.708 cm 0 0 m 0 0 l 0 -2.254 l 0 0 l h S Q BT 0 0 0 1 k /GS1 gs /C2_1 1 Tf 4.495 0 0 4.648 162.6129 500.8959 Tm <0250>Tj 0.743 0 Td <025F>Tj 0.496 0 Td <0267>Tj 0.496 0 Td <0261>Tj 0.495 0 Td <026D>Tj 0.372 0 Td <026A>Tj 0.496 0 Td <0262>Tj 0.497 0 Td <026A>Tj /TT1 1 Tf 0.496 0 Td (.)Tj ET 0 0 0 0 k /GS0 gs 62.577 496.444 195.474 -127.026 re f* 0 0 0 0.25 K q 1 0 0 1 95.0585 369.9741 cm 0 0 m 0 126.47 l S Q q 1 0 0 1 127.5397 369.9741 cm 0 0 m 0 126.47 l S Q q 1 0 0 1 160.0212 369.9741 cm 0 0 m 0 126.47 l S Q q 1 0 0 1 192.5024 369.9741 cm 0 0 m 0 126.47 l S Q q 1 0 0 1 224.9842 369.9741 cm 0 0 m 0 126.47 l S Q q 1 0 0 1 62.577 381.4687 cm 0 0 m 194.916 0 l S Q q 1 0 0 1 62.577 392.9638 cm 0 0 m 194.916 0 l S Q q 1 0 0 1 62.577 404.4583 cm 0 0 m 194.916 0 l S Q q 1 0 0 1 62.577 415.9529 cm 0 0 m 194.916 0 l S Q q 1 0 0 1 62.577 427.448 cm 0 0 m 194.916 0 l S Q q 1 0 0 1 62.577 438.9426 cm 0 0 m 194.916 0 l S Q q 1 0 0 1 62.577 450.4371 cm 0 0 m 194.916 0 l S Q q 1 0 0 1 62.577 461.9317 cm 0 0 m 194.916 0 l S Q q 1 0 0 1 62.577 473.4265 cm 0 0 m 194.916 0 l S Q q 1 0 0 1 62.577 484.9214 cm 0 0 m 194.916 0 l S Q 0 0.994 1 0 K 0.557 w q 1 0 0 1 95.0585 472.0627 cm 0 0 m 0.362 0 l 0.362 -1.363 l 1.978 -1.363 l 1.978 -2.728 l 2.674 -2.728 l 2.674 -4.091 l 2.98 -4.091 l 2.98 -5.483 l 3.092 -5.483 l 3.092 -6.846 l 4.095 -6.846 l 4.095 -8.21 l 4.541 -8.21 l 4.541 -9.574 l 4.791 -9.574 l 4.791 -10.938 l 5.07 -10.938 l 5.07 -12.302 l 6.017 -12.302 l 6.017 -13.693 l 6.212 -13.693 l 6.212 -15.057 l 6.518 -15.057 l 6.518 -16.421 l 7.521 -16.421 l 7.521 -17.784 l 8.218 -17.784 l 8.218 -19.148 l 8.914 -19.148 l 8.914 -20.54 l 8.97 -20.54 l 8.97 -21.904 l 9.444 -21.904 l 9.444 -23.268 l 10.196 -23.268 l 10.196 -24.659 l 11.644 -24.659 l 11.644 -26.051 l 12.591 -26.051 l 12.591 -27.442 l 13.789 -27.442 l 13.789 -28.834 l 14.319 -28.834 l 14.319 -30.226 l 14.374 -30.226 l 14.374 -31.589 l 16.297 -31.589 l 16.297 -32.981 l 18.358 -32.981 l 18.358 -34.373 l 18.358 -35.764 l 18.692 -35.764 l 18.692 -37.156 l 19.221 -37.156 l 19.221 -38.548 l 19.472 -38.548 l 19.472 -39.939 l 19.5 -39.939 l 19.5 -41.331 l 19.528 -41.331 l 19.528 -42.722 l 19.611 -42.722 l 19.611 -44.114 l 21.366 -44.114 l 21.366 -45.505 l 23.567 -45.505 l 23.567 -46.897 l 25.656 -46.897 l 25.656 -48.289 l 25.684 -48.289 l 25.684 -49.681 l 26.13 -49.681 l 26.13 -51.072 l 27.077 -51.072 l 27.077 -52.492 l 28.776 -52.492 l 28.776 -53.911 l 29.556 -53.911 l 29.556 -55.331 l 30.448 -55.331 l 30.448 -56.75 l 31.255 -56.75 l 31.255 -58.17 l 31.339 -58.17 l 31.339 -59.588 l 34.264 -59.588 l 34.264 -61.036 l 34.988 -61.036 l 34.988 -62.511 l 36.855 -62.511 l 36.855 -64.014 l 39.334 -64.014 l 39.334 -65.517 l 40.114 -65.517 l 40.114 -67.02 l 45.129 -67.02 l 45.129 -68.578 l 47.914 -68.578 l 47.914 -70.109 l 48.499 -70.109 l 48.499 -71.724 l 49.809 -71.724 l 49.809 -73.394 l 51.563 -73.394 l 51.563 -75.314 l 52.678 -75.314 l 52.678 -77.234 l 72.596 -77.234 l 72.596 -80.546 l 73.125 -80.546 l 73.125 -83.858 l 89.004 -83.858 l 97.138 -83.858 l 107.389 -83.858 l 108.142 -83.858 l 117.334 -83.858 l 120.9 -83.858 l 121.123 -83.858 l 139.397 -83.858 l 142.767 -83.858 l S Q 0 0.994 1 0 k q 1 0 0 1 93.7494 471.924 cm 0 0 m 2.228 0 l h f Q 0.279 w q 1 0 0 1 93.749 471.9236 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 94.8636 470.8107 cm 0 0 m 0 2.227 l h f Q q 1 0 0 1 94.8634 473.0369 cm 0 0 m 0 0 l 0 -2.227 l 0 0 l h S Q q 1 0 0 1 94.3065 470.8107 cm 0 0 m 2.228 0 l h f Q q 1 0 0 1 94.3062 470.8103 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 95.4207 469.6974 cm 0 0 m 0 2.227 l h f Q q 1 0 0 1 95.4206 471.9236 cm 0 0 m 0 0 l 0 -2.227 l 0 0 l h S Q q 1 0 0 1 95.9778 469.1403 cm 0 0 m 2.228 0 l h f Q q 1 0 0 1 95.9775 469.1403 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 97.092 468.027 cm 0 0 m 0 2.227 l h f Q q 1 0 0 1 97.0919 470.2536 cm 0 0 m 0 0 l 0 -2.227 l 0 0 l h S Q q 1 0 0 1 96.5349 468.027 cm 0 0 m 2.228 0 l h f Q q 1 0 0 1 96.5347 468.0273 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 97.6491 466.9137 cm 0 0 m 0 2.227 l h f Q q 1 0 0 1 97.6492 469.1403 cm 0 0 m 0 0 l 0 -2.227 l 0 0 l h S Q q 1 0 0 1 97.092 466.3575 cm 0 0 m 2.228 0 l h f Q q 1 0 0 1 97.0919 466.3572 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 98.2062 465.2442 cm 0 0 m 0 2.227 l h f Q q 1 0 0 1 98.2061 467.4706 cm 0 0 m 0 0 l 0 -2.227 l 0 0 l h S Q q 1 0 0 1 97.092 465.2442 cm 0 0 m 2.228 0 l h f Q q 1 0 0 1 97.0919 465.244 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 98.2062 464.1309 cm 0 0 m 0 2.227 l h f Q q 1 0 0 1 98.2061 466.3572 cm 0 0 m 0 0 l 0 -2.227 l 0 0 l h S Q q 1 0 0 1 98.2062 463.5738 cm 0 0 m 2.228 0 l h f Q q 1 0 0 1 98.2061 463.5739 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 99.3204 462.4605 cm 0 0 m 0 2.227 l h f Q q 1 0 0 1 99.3205 464.6873 cm 0 0 m 0 0 l 0 -2.227 l 0 0 l h S Q q 1 0 0 1 98.2062 462.4605 cm 0 0 m 2.228 0 l h f Q q 1 0 0 1 98.2061 462.4606 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 99.3204 461.3472 cm 0 0 m 0 2.227 l h f Q q 1 0 0 1 99.3205 463.5739 cm 0 0 m 0 0 l 0 -2.227 l 0 0 l h S Q q 1 0 0 1 98.7633 461.3472 cm 0 0 m 2.228 0 l h f Q q 1 0 0 1 98.7633 461.3473 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 99.8775 460.2339 cm 0 0 m 0 2.227 l h f Q q 1 0 0 1 99.8777 462.4606 cm 0 0 m 0 0 l 0 -2.227 l 0 0 l h S Q q 1 0 0 1 98.7633 459.6777 cm 0 0 m 2.228 0 l h f Q q 1 0 0 1 98.7633 459.6773 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 99.8775 458.5644 cm 0 0 m 0 2.227 l h f Q q 1 0 0 1 99.8777 460.7906 cm 0 0 m 0 0 l 0 -2.227 l 0 0 l h S Q q 1 0 0 1 99.8775 458.5644 cm 0 0 m 2.229 0 l h f Q q 1 0 0 1 99.8777 458.5643 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 100.9917 457.4511 cm 0 0 m 0 2.227 l h f Q q 1 0 0 1 100.9918 459.6773 cm 0 0 m 0 0 l 0 -2.227 l 0 0 l h S Q q 1 0 0 1 99.8775 456.894 cm 0 0 m 2.229 0 l h f Q q 1 0 0 1 99.8777 456.8943 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 100.9917 455.7807 cm 0 0 m 0 2.227 l h f Q q 1 0 0 1 100.9918 458.0076 cm 0 0 m 0 0 l 0 -2.227 l 0 0 l h S Q q 1 0 0 1 100.4346 455.7807 cm 0 0 m 2.228 0 l h f Q q 1 0 0 1 100.4346 455.781 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 101.5488 454.6674 cm 0 0 m 0 2.227 l h f Q q 1 0 0 1 101.549 456.8943 cm 0 0 m 0 0 l 0 -2.227 l 0 0 l h S Q q 1 0 0 1 101.5488 454.1112 cm 0 0 m 2.229 0 l h f Q q 1 0 0 1 101.549 454.111 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 102.663 452.9979 cm 0 0 m 0 2.227 l h f Q q 1 0 0 1 102.6635 455.2243 cm 0 0 m 0 0 l 0 -2.227 l 0 0 l h S Q q 1 0 0 1 102.1059 452.9979 cm 0 0 m 2.229 0 l h f Q q 1 0 0 1 102.1062 452.9976 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 103.2201 451.8846 cm 0 0 m 0 2.227 l h f Q q 1 0 0 1 103.2204 454.111 cm 0 0 m 0 0 l 0 -2.227 l 0 0 l h S Q q 1 0 0 1 102.663 451.3275 cm 0 0 m 2.229 0 l h f Q q 1 0 0 1 102.6635 451.3279 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 103.7772 450.2142 cm 0 0 m 0 2.227 l h f Q q 1 0 0 1 103.7776 452.441 cm 0 0 m 0 0 l 0 -2.227 l 0 0 l h S Q q 1 0 0 1 102.663 450.2142 cm 0 0 m 2.229 0 l h f Q q 1 0 0 1 102.6635 450.2146 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 103.7772 449.1009 cm 0 0 m 0 2.227 l h f Q q 1 0 0 1 103.7776 451.3279 cm 0 0 m 0 0 l 0 -2.227 l 0 0 l h S Q q 1 0 0 1 103.2201 448.5447 cm 0 0 m 2.229 0 l h f Q q 1 0 0 1 103.2204 448.5446 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 104.3352 447.4035 cm 0 0 m 0 2.254 l h f Q q 1 0 0 1 104.3348 449.6579 cm 0 0 m 0 0 l 0 -2.254 l 0 0 l h S Q q 1 0 0 1 104.3352 447.4035 cm 0 0 m 2.228 0 l h f Q q 1 0 0 1 104.3348 447.4035 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 105.4485 446.2902 cm 0 0 m 0 2.255 l h f Q q 1 0 0 1 105.4489 448.5446 cm 0 0 m 0 0 l 0 -2.254 l 0 0 l h S Q q 1 0 0 1 105.4485 445.7331 cm 0 0 m 2.229 0 l h f Q q 1 0 0 1 105.4489 445.7335 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 106.5636 444.6207 cm 0 0 m 0 2.227 l h f Q q 1 0 0 1 106.5633 446.8469 cm 0 0 m 0 0 l 0 -2.227 l 0 0 l h S Q q 1 0 0 1 106.5636 444.6198 cm 0 0 m 2.228 0 l h f Q q 1 0 0 1 106.5633 444.6202 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 107.6778 443.5065 cm 0 0 m 0 2.227 l h f Q q 1 0 0 1 107.6775 445.7335 cm 0 0 m 0 0 l 0 -2.227 l 0 0 l h S Q q 1 0 0 1 107.6778 442.9503 cm 0 0 m 2.228 0 l h f Q q 1 0 0 1 107.6775 442.9502 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 108.792 441.837 cm 0 0 m 0 2.227 l h f Q q 1 0 0 1 108.7919 444.0635 cm 0 0 m 0 0 l 0 -2.227 l 0 0 l h S Q q 1 0 0 1 108.2349 441.837 cm 0 0 m 2.228 0 l h f Q q 1 0 0 1 108.2347 441.8369 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 109.3491 440.7237 cm 0 0 m 0 2.227 l h f Q q 1 0 0 1 109.3491 442.9502 cm 0 0 m 0 0 l 0 -2.227 l 0 0 l h S Q q 1 0 0 1 108.2349 440.1666 cm 0 0 m 2.228 0 l h f Q q 1 0 0 1 108.2347 440.1669 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 109.3491 439.0533 cm 0 0 m 0 2.227 l h f Q q 1 0 0 1 109.3491 441.2802 cm 0 0 m 0 0 l 0 -2.227 l 0 0 l h S Q q 1 0 0 1 110.4633 439.0542 cm 0 0 m 2.228 0 l h f Q q 1 0 0 1 110.4632 439.0539 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 111.5775 437.94 cm 0 0 m 0 2.227 l h f Q q 1 0 0 1 111.5777 440.1669 cm 0 0 m 0 0 l 0 -2.227 l 0 0 l h S Q q 1 0 0 1 112.1346 437.3838 cm 0 0 m 2.229 0 l h f Q q 1 0 0 1 112.1349 437.3839 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 113.2488 436.2705 cm 0 0 m 0 2.227 l h f Q q 1 0 0 1 113.249 438.4972 cm 0 0 m 0 0 l 0 -2.227 l 0 0 l h S Q q 1 0 0 1 112.1346 436.2705 cm 0 0 m 2.229 0 l h f Q q 1 0 0 1 112.1349 436.2706 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 113.2488 435.1572 cm 0 0 m 0 2.227 l h f Q q 1 0 0 1 113.249 437.3839 cm 0 0 m 0 0 l 0 -2.227 l 0 0 l h S Q q 1 0 0 1 112.6917 434.6001 cm 0 0 m 2.229 0 l h f Q q 1 0 0 1 112.6918 434.6006 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 113.8059 433.4877 cm 0 0 m 0 2.227 l h f Q q 1 0 0 1 113.8062 435.7139 cm 0 0 m 0 0 l 0 -2.227 l 0 0 l h S Q q 1 0 0 1 113.2488 433.4868 cm 0 0 m 2.229 0 l h f Q q 1 0 0 1 113.249 433.4872 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 114.363 432.3744 cm 0 0 m 0 2.226 l h f Q q 1 0 0 1 114.3634 434.6006 cm 0 0 m 0 0 l 0 -2.227 l 0 0 l h S Q q 1 0 0 1 113.2488 431.8173 cm 0 0 m 2.229 0 l h f Q q 1 0 0 1 113.249 431.8175 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 114.363 430.704 cm 0 0 m 0 2.227 l h f Q q 1 0 0 1 114.3634 432.9309 cm 0 0 m 0 0 l 0 -2.227 l 0 0 l h S Q q 1 0 0 1 113.2488 430.704 cm 0 0 m 2.229 0 l h f Q q 1 0 0 1 113.249 430.7042 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 114.363 429.5907 cm 0 0 m 0 2.227 l h f Q q 1 0 0 1 114.3634 431.8175 cm 0 0 m 0 0 l 0 -2.227 l 0 0 l h S Q q 1 0 0 1 113.2488 429.0345 cm 0 0 m 2.229 0 l h f Q q 1 0 0 1 113.249 429.0342 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 114.363 427.9212 cm 0 0 m 0 2.227 l h f Q q 1 0 0 1 114.3634 430.1475 cm 0 0 m 0 0 l 0 -2.227 l 0 0 l h S Q q 1 0 0 1 113.8059 427.9212 cm 0 0 m 2.229 0 l h f Q q 1 0 0 1 113.8062 427.9209 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 114.9201 426.8079 cm 0 0 m 0 2.227 l h f Q q 1 0 0 1 114.9204 429.0342 cm 0 0 m 0 0 l 0 -2.227 l 0 0 l h S Q q 1 0 0 1 115.4772 426.8079 cm 0 0 m 2.229 0 l h f Q q 1 0 0 1 115.4776 426.8076 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 116.5923 425.6946 cm 0 0 m 0 2.227 l h f Q q 1 0 0 1 116.592 427.9209 cm 0 0 m 0 0 l 0 -2.227 l 0 0 l h S Q q 1 0 0 1 117.7065 425.1375 cm 0 0 m 2.228 0 l h f Q q 1 0 0 1 117.7061 425.1376 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 118.8207 424.0242 cm 0 0 m 0 2.227 l h f Q q 1 0 0 1 118.8206 426.2509 cm 0 0 m 0 0 l 0 -2.227 l 0 0 l h S Q q 1 0 0 1 119.3778 424.0242 cm 0 0 m 2.228 0 l h f Q q 1 0 0 1 119.3778 424.0243 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 120.492 422.9109 cm 0 0 m 0 2.227 l h f Q q 1 0 0 1 120.4919 425.1376 cm 0 0 m 0 0 l 0 -2.227 l 0 0 l h S Q q 1 0 0 1 119.3778 422.3538 cm 0 0 m 2.228 0 l h f Q q 1 0 0 1 119.3778 422.3542 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 120.492 421.2414 cm 0 0 m 0 2.227 l h f Q q 1 0 0 1 120.4919 423.4676 cm 0 0 m 0 0 l 0 -2.227 l 0 0 l h S Q q 1 0 0 1 119.9349 421.2414 cm 0 0 m 2.228 0 l h f Q q 1 0 0 1 119.9347 421.241 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 121.0491 420.1272 cm 0 0 m 0 2.227 l h f Q q 1 0 0 1 121.0491 422.3542 cm 0 0 m 0 0 l 0 -2.227 l 0 0 l h S Q q 1 0 0 1 121.0491 419.5431 cm 0 0 m 2.228 0 l h f Q q 1 0 0 1 121.0491 419.5432 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 122.1633 418.4298 cm 0 0 m 0 2.254 l h f Q q 1 0 0 1 122.1632 420.6843 cm 0 0 m 0 0 l 0 -2.254 l 0 0 l h S Q q 1 0 0 1 122.7204 417.8736 cm 0 0 m 2.229 0 l h f Q q 1 0 0 1 122.7204 417.8732 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 123.8346 416.7603 cm 0 0 m 0 2.227 l h f Q q 1 0 0 1 123.8349 418.9866 cm 0 0 m 0 0 l 0 -2.226 l 0 0 l h S Q q 1 0 0 1 123.2775 416.7603 cm 0 0 m 2.229 0 l h f Q q 1 0 0 1 123.2776 416.7604 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 124.3917 415.647 cm 0 0 m 0 2.227 l h f Q q 1 0 0 1 124.3918 417.8732 cm 0 0 m 0 0 l 0 -2.226 l 0 0 l h S Q q 1 0 0 1 124.3917 415.0908 cm 0 0 m 2.229 0 l h f Q q 1 0 0 1 124.3918 415.0905 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 125.5059 413.9775 cm 0 0 m 0 2.227 l h f Q q 1 0 0 1 125.5062 416.2037 cm 0 0 m 0 0 l 0 -2.227 l 0 0 l h S Q q 1 0 0 1 124.9488 413.9775 cm 0 0 m 2.229 0 l h f Q q 1 0 0 1 124.949 413.9771 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 126.063 412.8642 cm 0 0 m 0 2.227 l h f Q q 1 0 0 1 126.0634 415.0905 cm 0 0 m 0 0 l 0 -2.227 l 0 0 l h S Q q 1 0 0 1 125.5059 412.3071 cm 0 0 m 2.229 0 l h f Q q 1 0 0 1 125.5062 412.3072 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 126.6201 411.1938 cm 0 0 m 0 2.227 l h f Q q 1 0 0 1 126.6203 413.4204 cm 0 0 m 0 0 l 0 -2.227 l 0 0 l h S Q q 1 0 0 1 128.2923 411.1938 cm 0 0 m 2.228 0 l h f Q q 1 0 0 1 128.292 411.1938 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 129.4065 410.0805 cm 0 0 m 0 2.227 l h f Q q 1 0 0 1 129.4061 412.3072 cm 0 0 m 0 0 l 0 -2.227 l 0 0 l h S Q q 1 0 0 1 128.8494 409.5234 cm 0 0 m 2.228 0 l h f Q q 1 0 0 1 128.8492 409.5238 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 129.9636 408.4101 cm 0 0 m 0 2.227 l h f Q q 1 0 0 1 129.9633 410.6371 cm 0 0 m 0 0 l 0 -2.227 l 0 0 l h S Q q 1 0 0 1 131.0778 407.8539 cm 0 0 m 2.228 0 l h f Q q 1 0 0 1 131.0777 407.8539 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 132.192 406.7406 cm 0 0 m 0 2.227 l h f Q q 1 0 0 1 132.1918 408.9672 cm 0 0 m 0 0 l 0 -2.227 l 0 0 l h S Q q 1 0 0 1 133.3062 406.7406 cm 0 0 m 2.229 0 l h f Q q 1 0 0 1 133.3062 406.7405 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 134.4204 405.6273 cm 0 0 m 0 2.227 l h f Q q 1 0 0 1 134.4204 407.8539 cm 0 0 m 0 0 l 0 -2.227 l 0 0 l h S Q q 1 0 0 1 133.8633 405.0702 cm 0 0 m 2.228 0 l h f Q q 1 0 0 1 133.8632 405.0706 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 134.9775 403.9569 cm 0 0 m 0 2.227 l h f Q q 1 0 0 1 134.9776 406.1838 cm 0 0 m 0 0 l 0 -2.227 l 0 0 l h S Q q 1 0 0 1 138.8772 403.4007 cm 0 0 m 2.229 0 l h f Q q 1 0 0 1 138.8775 403.4005 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 139.9923 402.2874 cm 0 0 m 0 2.227 l h f Q q 1 0 0 1 139.9919 404.5138 cm 0 0 m 0 0 l 0 -2.227 l 0 0 l h S Q q 1 0 0 1 141.6636 401.7303 cm 0 0 m 2.228 0 l h f Q q 1 0 0 1 141.6633 401.7305 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 142.7778 400.617 cm 0 0 m 0 2.227 l h f Q q 1 0 0 1 142.7777 402.8439 cm 0 0 m 0 0 l 0 -2.227 l 0 0 l h S Q q 1 0 0 1 142.2207 400.0608 cm 0 0 m 2.228 0 l h f Q q 1 0 0 1 142.2205 400.0611 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 143.3349 398.9475 cm 0 0 m 0 2.227 l h f Q q 1 0 0 1 143.3346 401.1739 cm 0 0 m 0 0 l 0 -2.226 l 0 0 l h S Q q 1 0 0 1 143.892 398.3913 cm 0 0 m 2.228 0 l h f Q q 1 0 0 1 143.8918 398.3911 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 145.0062 397.278 cm 0 0 m 0 2.227 l h f Q q 1 0 0 1 145.0063 399.5045 cm 0 0 m 0 0 l 0 -2.227 l 0 0 l h S Q q 1 0 0 1 145.5633 396.7209 cm 0 0 m 2.228 0 l h f Q q 1 0 0 1 145.5632 396.7211 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 146.6775 395.6076 cm 0 0 m 0 2.227 l h f Q q 1 0 0 1 146.6776 397.8344 cm 0 0 m 0 0 l 0 -2.227 l 0 0 l h S Q q 1 0 0 1 146.6775 395.0514 cm 0 0 m 2.229 0 l h f Q q 1 0 0 1 146.6776 395.0511 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 147.7917 393.9381 cm 0 0 m 0 2.227 l h f Q q 1 0 0 1 147.792 396.1645 cm 0 0 m 0 0 l 0 -2.227 l 0 0 l h S Q q 1 0 0 1 166.707 391.6836 cm 0 0 m 2.228 0 l h f Q q 1 0 0 1 166.7071 391.6834 cm 0 0 m 2.228 0 l 0 0 l h S Q q 1 0 0 1 167.8212 390.5703 cm 0 0 m 0 2.255 l h f Q q 1 0 0 1 167.821 392.8245 cm 0 0 m 0 0 l 0 -2.254 l 0 0 l h S Q q 1 0 0 1 167.2641 388.3437 cm 0 0 m 2.228 0 l h f Q q 1 0 0 1 167.2643 388.3434 cm 0 0 m 2.228 0 l 0 0 l h S Q q 1 0 0 1 168.3783 387.2304 cm 0 0 m 0 2.227 l h f Q q 1 0 0 1 168.3782 389.4568 cm 0 0 m 0 0 l 0 -2.227 l 0 0 l h S Q q 1 0 0 1 182.8638 388.3437 cm 0 0 m 2.229 0 l h f Q q 1 0 0 1 182.8639 388.3434 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 183.978 387.2304 cm 0 0 m 0 2.227 l h f Q q 1 0 0 1 183.9783 389.4568 cm 0 0 m 0 0 l 0 -2.227 l 0 0 l h S Q q 1 0 0 1 191.2212 388.3437 cm 0 0 m 2.228 0 l h f Q q 1 0 0 1 191.2209 388.3434 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 192.3354 387.2304 cm 0 0 m 0 2.227 l h f Q q 1 0 0 1 192.3353 389.4568 cm 0 0 m 0 0 l 0 -2.227 l 0 0 l h S Q q 1 0 0 1 201.2499 388.3437 cm 0 0 m 2.228 0 l h f Q q 1 0 0 1 201.2496 388.3434 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 202.3641 387.2304 cm 0 0 m 0 2.227 l h f Q q 1 0 0 1 202.364 389.4568 cm 0 0 m 0 0 l 0 -2.227 l 0 0 l h S Q q 1 0 0 1 202.3641 388.3437 cm 0 0 m 2.228 0 l h f Q q 1 0 0 1 202.364 388.3434 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 203.4783 387.2304 cm 0 0 m 0 2.227 l h f Q q 1 0 0 1 203.4784 389.4568 cm 0 0 m 0 0 l 0 -2.227 l 0 0 l h S Q q 1 0 0 1 211.2786 388.3437 cm 0 0 m 2.228 0 l h f Q q 1 0 0 1 211.2782 388.3434 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 212.3928 387.2304 cm 0 0 m 0 2.227 l h f Q q 1 0 0 1 212.3926 389.4568 cm 0 0 m 0 0 l 0 -2.227 l 0 0 l h S Q q 1 0 0 1 214.6212 388.3437 cm 0 0 m 2.228 0 l h f Q q 1 0 0 1 214.6214 388.3434 cm 0 0 m 2.228 0 l 0 0 l h S Q q 1 0 0 1 215.7354 387.2304 cm 0 0 m 0 2.227 l h f Q q 1 0 0 1 215.7353 389.4568 cm 0 0 m 0 0 l 0 -2.227 l 0 0 l h S Q q 1 0 0 1 215.1783 388.3437 cm 0 0 m 2.228 0 l h f Q q 1 0 0 1 215.1781 388.3434 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 216.2925 387.2304 cm 0 0 m 0 2.227 l h f Q q 1 0 0 1 216.2925 389.4568 cm 0 0 m 0 0 l 0 -2.227 l 0 0 l h S Q q 1 0 0 1 233.5356 388.3437 cm 0 0 m 2.229 0 l h f Q q 1 0 0 1 233.536 388.3434 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 234.6507 387.2304 cm 0 0 m 0 2.227 l h f Q q 1 0 0 1 234.6504 389.4568 cm 0 0 m 0 0 l 0 -2.227 l 0 0 l h S Q q 1 0 0 1 236.8791 388.3437 cm 0 0 m 2.228 0 l h f Q q 1 0 0 1 236.8792 388.3434 cm 0 0 m 2.228 0 l 0 0 l h S Q q 1 0 0 1 237.9933 387.2304 cm 0 0 m 0 2.227 l h f Q q 1 0 0 1 237.9931 389.4568 cm 0 0 m 0 0 l 0 -2.227 l 0 0 l h S Q q 1 0 0 1 103.7772 448.5447 cm 0 0 m 2.229 0 l h f Q q 1 0 0 1 103.7776 448.5446 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 104.8923 447.4035 cm 0 0 m 0 2.254 l h f Q q 1 0 0 1 104.892 449.6579 cm 0 0 m 0 0 l 0 -2.254 l 0 0 l h S Q q 1 0 0 1 120.492 421.2414 cm 0 0 m 2.228 0 l h f Q q 1 0 0 1 120.4919 421.241 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 121.6062 420.1272 cm 0 0 m 0 2.227 l h f Q q 1 0 0 1 121.6063 422.3542 cm 0 0 m 0 0 l 0 -2.227 l 0 0 l h S Q q 1 0 0 1 126.6201 412.3071 cm 0 0 m 2.229 0 l h f Q q 1 0 0 1 126.6203 412.3072 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 127.7343 411.1938 cm 0 0 m 0 2.227 l h f Q q 1 0 0 1 127.7347 413.4204 cm 0 0 m 0 0 l 0 -2.227 l 0 0 l h S Q q 1 0 0 1 130.5207 409.5234 cm 0 0 m 2.228 0 l h f Q q 1 0 0 1 130.5205 409.5238 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 131.6349 408.4101 cm 0 0 m 0 2.227 l h f Q q 1 0 0 1 131.6346 410.6371 cm 0 0 m 0 0 l 0 -2.227 l 0 0 l h S Q q 1 0 0 1 137.763 405.0702 cm 0 0 m 2.229 0 l h f Q q 1 0 0 1 137.7634 405.0706 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 138.8772 403.9569 cm 0 0 m 0 2.227 l h f Q q 1 0 0 1 138.8775 406.1838 cm 0 0 m 0 0 l 0 -2.227 l 0 0 l h S Q q 1 0 0 1 142.2207 401.7303 cm 0 0 m 2.228 0 l h f Q q 1 0 0 1 142.2205 401.7305 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 143.3349 400.617 cm 0 0 m 0 2.227 l h f Q q 1 0 0 1 143.3346 402.8439 cm 0 0 m 0 0 l 0 -2.227 l 0 0 l h S Q q 1 0 0 1 142.7778 400.0608 cm 0 0 m 2.228 0 l h f Q q 1 0 0 1 142.7777 400.0611 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 143.892 398.9475 cm 0 0 m 0 2.227 l h f Q q 1 0 0 1 143.8918 401.1739 cm 0 0 m 0 0 l 0 -2.226 l 0 0 l h S Q q 1 0 0 1 144.4491 398.3913 cm 0 0 m 2.228 0 l h f Q q 1 0 0 1 144.449 398.3911 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 145.5633 397.278 cm 0 0 m 0 2.227 l h f Q q 1 0 0 1 145.5632 399.5045 cm 0 0 m 0 0 l 0 -2.227 l 0 0 l h S Q q 1 0 0 1 144.4491 398.3913 cm 0 0 m 2.228 0 l h f Q q 1 0 0 1 144.449 398.3911 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 145.5633 397.278 cm 0 0 m 0 2.227 l h f Q q 1 0 0 1 145.5632 399.5045 cm 0 0 m 0 0 l 0 -2.227 l 0 0 l h S Q q 1 0 0 1 144.4491 398.3913 cm 0 0 m 2.228 0 l h f Q q 1 0 0 1 144.449 398.3911 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 145.5633 397.278 cm 0 0 m 0 2.227 l h f Q q 1 0 0 1 145.5632 399.5045 cm 0 0 m 0 0 l 0 -2.227 l 0 0 l h S Q q 1 0 0 1 149.463 395.0514 cm 0 0 m 2.229 0 l h f Q q 1 0 0 1 149.4633 395.0511 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 150.5772 393.9381 cm 0 0 m 0 2.227 l h f Q q 1 0 0 1 150.5775 396.1645 cm 0 0 m 0 0 l 0 -2.227 l 0 0 l h S Q q 1 0 0 1 151.6923 395.0514 cm 0 0 m 2.2 0 l h f Q q 1 0 0 1 151.6919 395.0511 cm 0 0 m 2.2 0 l 0 0 l h S Q q 1 0 0 1 152.8065 393.9381 cm 0 0 m 0 2.227 l h f Q q 1 0 0 1 152.8063 396.1645 cm 0 0 m 0 0 l 0 -2.227 l 0 0 l h S Q q 1 0 0 1 152.2494 395.0514 cm 0 0 m 2.201 0 l h f Q q 1 0 0 1 152.2491 395.0511 cm 0 0 m 2.2 0 l 0 0 l h S Q q 1 0 0 1 153.3357 393.9381 cm 0 0 m 0 2.227 l h f Q q 1 0 0 1 153.3353 396.1645 cm 0 0 m 0 0 l 0 -2.227 l 0 0 l h S Q q 1 0 0 1 153.8928 395.0514 cm 0 0 m 2.228 0 l h f Q q 1 0 0 1 153.8925 395.0511 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 155.007 393.9381 cm 0 0 m 0 2.227 l h f Q q 1 0 0 1 155.0069 396.1645 cm 0 0 m 0 0 l 0 -2.227 l 0 0 l h S Q q 1 0 0 1 156.6783 395.0514 cm 0 0 m 2.228 0 l h f Q q 1 0 0 1 156.6785 395.0511 cm 0 0 m 2.228 0 l 0 0 l h S Q q 1 0 0 1 157.7925 393.9381 cm 0 0 m 0 2.227 l h f Q q 1 0 0 1 157.7929 396.1645 cm 0 0 m 0 0 l 0 -2.227 l 0 0 l h S Q q 1 0 0 1 157.7925 395.0514 cm 0 0 m 2.228 0 l h f Q q 1 0 0 1 157.7929 395.0511 cm 0 0 m 2.228 0 l 0 0 l h S Q q 1 0 0 1 158.9067 393.9381 cm 0 0 m 0 2.227 l h f Q q 1 0 0 1 158.9068 396.1645 cm 0 0 m 0 0 l 0 -2.227 l 0 0 l h S Q q 1 0 0 1 158.9067 395.0514 cm 0 0 m 2.229 0 l h f Q q 1 0 0 1 158.9068 395.0511 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 160.0209 393.9381 cm 0 0 m 0 2.227 l h f Q q 1 0 0 1 160.0212 396.1645 cm 0 0 m 0 0 l 0 -2.227 l 0 0 l h S Q q 1 0 0 1 159.4638 395.0514 cm 0 0 m 2.229 0 l h f Q q 1 0 0 1 159.464 395.0511 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 160.578 393.9381 cm 0 0 m 0 2.227 l h f Q q 1 0 0 1 160.5784 396.1645 cm 0 0 m 0 0 l 0 -2.227 l 0 0 l h S Q q 1 0 0 1 182.8638 388.3437 cm 0 0 m 2.229 0 l h f Q q 1 0 0 1 182.8639 388.3434 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 183.978 387.2304 cm 0 0 m 0 2.227 l h f Q q 1 0 0 1 183.9783 389.4568 cm 0 0 m 0 0 l 0 -2.227 l 0 0 l h S Q q 1 0 0 1 191.2212 388.3437 cm 0 0 m 2.228 0 l h f Q q 1 0 0 1 191.2209 388.3434 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 192.3354 387.2304 cm 0 0 m 0 2.227 l h f Q q 1 0 0 1 192.3353 389.4568 cm 0 0 m 0 0 l 0 -2.227 l 0 0 l h S Q q 1 0 0 1 201.2499 388.3437 cm 0 0 m 2.228 0 l h f Q q 1 0 0 1 201.2496 388.3434 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 202.3641 387.2304 cm 0 0 m 0 2.227 l h f Q q 1 0 0 1 202.364 389.4568 cm 0 0 m 0 0 l 0 -2.227 l 0 0 l h S Q q 1 0 0 1 202.3641 388.3437 cm 0 0 m 2.228 0 l h f Q q 1 0 0 1 202.364 388.3434 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 203.4783 387.2304 cm 0 0 m 0 2.227 l h f Q q 1 0 0 1 203.4784 389.4568 cm 0 0 m 0 0 l 0 -2.227 l 0 0 l h S Q q 1 0 0 1 211.2786 388.3437 cm 0 0 m 2.228 0 l h f Q q 1 0 0 1 211.2782 388.3434 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 212.3928 387.2304 cm 0 0 m 0 2.227 l h f Q q 1 0 0 1 212.3926 389.4568 cm 0 0 m 0 0 l 0 -2.227 l 0 0 l h S Q q 1 0 0 1 214.6212 388.3437 cm 0 0 m 2.228 0 l h f Q q 1 0 0 1 214.6214 388.3434 cm 0 0 m 2.228 0 l 0 0 l h S Q q 1 0 0 1 215.7354 387.2304 cm 0 0 m 0 2.227 l h f Q q 1 0 0 1 215.7353 389.4568 cm 0 0 m 0 0 l 0 -2.227 l 0 0 l h S Q q 1 0 0 1 215.1783 388.3437 cm 0 0 m 2.228 0 l h f Q q 1 0 0 1 215.1781 388.3434 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 216.2925 387.2304 cm 0 0 m 0 2.227 l h f Q q 1 0 0 1 216.2925 389.4568 cm 0 0 m 0 0 l 0 -2.227 l 0 0 l h S Q q 1 0 0 1 233.5356 388.3437 cm 0 0 m 2.229 0 l h f Q q 1 0 0 1 233.536 388.3434 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 234.6507 387.2304 cm 0 0 m 0 2.227 l h f Q q 1 0 0 1 234.6504 389.4568 cm 0 0 m 0 0 l 0 -2.227 l 0 0 l h S Q q 1 0 0 1 236.8791 388.3437 cm 0 0 m 2.228 0 l h f Q q 1 0 0 1 236.8792 388.3434 cm 0 0 m 2.228 0 l 0 0 l h S Q q 1 0 0 1 237.9933 387.2304 cm 0 0 m 0 2.227 l h f Q q 1 0 0 1 237.9931 389.4568 cm 0 0 m 0 0 l 0 -2.227 l 0 0 l h S Q q 42.52 351.021 221.102 165.49 re W n 0.557 w q 1 0 0 1 93.749 472.202 cm 0 0 m 0 0.464 0.372 0.835 0.836 0.835 c 1.3 0.835 1.672 0.464 1.672 0 c 1.672 -0.464 1.3 -0.835 0.836 -0.835 c 0.372 -0.835 0 -0.464 0 0 c h S Q q 1 0 0 1 94.3062 471.0886 cm 0 0 m 0 0.464 0.372 0.835 0.836 0.835 c 1.3 0.835 1.672 0.464 1.672 0 c 1.672 -0.464 1.3 -0.835 0.836 -0.835 c 0.372 -0.835 0 -0.464 0 0 c h S Q q 1 0 0 1 95.9775 469.4186 cm 0 0 m 0 0.464 0.372 0.835 0.836 0.835 c 1.3 0.835 1.672 0.464 1.672 0 c 1.672 -0.464 1.3 -0.835 0.836 -0.835 c 0.372 -0.835 0 -0.464 0 0 c h S Q q 1 0 0 1 96.5347 468.3053 cm 0 0 m 0 0.464 0.372 0.835 0.836 0.835 c 1.3 0.835 1.672 0.464 1.672 0 c 1.672 -0.464 1.3 -0.835 0.836 -0.835 c 0.372 -0.835 0 -0.464 0 0 c h S Q q 1 0 0 1 97.0919 466.6356 cm 0 0 m 0 0.464 0.372 0.835 0.836 0.835 c 1.3 0.835 1.672 0.464 1.672 0 c 1.672 -0.464 1.3 -0.835 0.836 -0.835 c 0.372 -0.835 0 -0.464 0 0 c h S Q q 1 0 0 1 97.0919 465.5223 cm 0 0 m 0 0.464 0.372 0.835 0.836 0.835 c 1.3 0.835 1.672 0.464 1.672 0 c 1.672 -0.464 1.3 -0.835 0.836 -0.835 c 0.372 -0.835 0 -0.464 0 0 c h S Q q 1 0 0 1 98.2061 463.8523 cm 0 0 m 0 0.464 0.372 0.835 0.836 0.835 c 1.3 0.835 1.672 0.464 1.672 0 c 1.672 -0.464 1.3 -0.835 0.836 -0.835 c 0.372 -0.835 0 -0.464 0 0 c h S Q q 1 0 0 1 98.2061 462.739 cm 0 0 m 0 0.464 0.372 0.835 0.836 0.835 c 1.3 0.835 1.672 0.464 1.672 0 c 1.672 -0.464 1.3 -0.835 0.836 -0.835 c 0.372 -0.835 0 -0.464 0 0 c h S Q q 1 0 0 1 98.7633 461.6256 cm 0 0 m 0 0.464 0.372 0.835 0.836 0.835 c 1.3 0.835 1.672 0.464 1.672 0 c 1.672 -0.464 1.3 -0.835 0.836 -0.835 c 0.372 -0.835 0 -0.464 0 0 c h S Q q 1 0 0 1 98.7633 459.9559 cm 0 0 m 0 0.464 0.372 0.835 0.836 0.835 c 1.3 0.835 1.672 0.464 1.672 0 c 1.672 -0.464 1.3 -0.835 0.836 -0.835 c 0.372 -0.835 0 -0.464 0 0 c h S Q q 1 0 0 1 99.8777 458.8426 cm 0 0 m 0 0.464 0.372 0.835 0.836 0.835 c 1.3 0.835 1.672 0.464 1.672 0 c 1.672 -0.464 1.3 -0.835 0.836 -0.835 c 0.372 -0.835 0 -0.464 0 0 c h S Q q 1 0 0 1 99.8777 457.1726 cm 0 0 m 0 0.464 0.372 0.835 0.836 0.835 c 1.3 0.835 1.672 0.464 1.672 0 c 1.672 -0.464 1.3 -0.835 0.836 -0.835 c 0.372 -0.835 0 -0.464 0 0 c h S Q q 1 0 0 1 100.4346 456.0593 cm 0 0 m 0 0.464 0.372 0.835 0.836 0.835 c 1.3 0.835 1.672 0.464 1.672 0 c 1.672 -0.464 1.3 -0.835 0.836 -0.835 c 0.372 -0.835 0 -0.464 0 0 c h S Q q 1 0 0 1 101.549 454.3893 cm 0 0 m 0 0.464 0.372 0.835 0.836 0.835 c 1.3 0.835 1.672 0.464 1.672 0 c 1.672 -0.464 1.3 -0.835 0.836 -0.835 c 0.372 -0.835 0 -0.464 0 0 c h S Q q 1 0 0 1 102.1062 453.2759 cm 0 0 m 0 0.464 0.372 0.835 0.836 0.835 c 1.3 0.835 1.672 0.464 1.672 0 c 1.672 -0.464 1.3 -0.835 0.836 -0.835 c 0.372 -0.835 0 -0.464 0 0 c h S Q q 1 0 0 1 102.6635 451.606 cm 0 0 m 0 0.464 0.372 0.835 0.836 0.835 c 1.3 0.835 1.672 0.464 1.672 0 c 1.672 -0.464 1.3 -0.835 0.836 -0.835 c 0.372 -0.835 0 -0.464 0 0 c h S Q q 1 0 0 1 102.6635 450.4929 cm 0 0 m 0 0.464 0.372 0.835 0.836 0.835 c 1.3 0.835 1.672 0.464 1.672 0 c 1.672 -0.464 1.3 -0.835 0.836 -0.835 c 0.372 -0.835 0 -0.464 0 0 c h S Q q 1 0 0 1 103.2204 448.8229 cm 0 0 m 0 0.464 0.372 0.835 0.836 0.835 c 1.3 0.835 1.672 0.464 1.672 0 c 1.672 -0.464 1.3 -0.835 0.836 -0.835 c 0.372 -0.835 0 -0.464 0 0 c h S Q q 1 0 0 1 104.3348 447.6957 cm 0 0 m 0 0.471 0.372 0.849 0.836 0.849 c 1.3 0.849 1.672 0.471 1.672 0 c 1.672 -0.472 1.3 -0.849 0.836 -0.849 c 0.372 -0.849 0 -0.472 0 0 c h S Q q 1 0 0 1 105.4489 446.0118 cm 0 0 m 0 0.464 0.372 0.835 0.836 0.835 c 1.3 0.835 1.672 0.464 1.672 0 c 1.672 -0.464 1.3 -0.835 0.836 -0.835 c 0.372 -0.835 0 -0.464 0 0 c h S Q q 1 0 0 1 106.5633 444.8986 cm 0 0 m 0 0.464 0.372 0.835 0.836 0.835 c 1.3 0.835 1.672 0.464 1.672 0 c 1.672 -0.464 1.3 -0.835 0.836 -0.835 c 0.372 -0.835 0 -0.464 0 0 c h S Q q 1 0 0 1 107.6775 443.2285 cm 0 0 m 0 0.464 0.372 0.835 0.836 0.835 c 1.3 0.835 1.672 0.464 1.672 0 c 1.672 -0.464 1.3 -0.835 0.836 -0.835 c 0.372 -0.835 0 -0.464 0 0 c h S Q q 1 0 0 1 108.2347 442.1152 cm 0 0 m 0 0.464 0.372 0.835 0.836 0.835 c 1.3 0.835 1.672 0.464 1.672 0 c 1.672 -0.464 1.3 -0.835 0.836 -0.835 c 0.372 -0.835 0 -0.464 0 0 c h S Q q 1 0 0 1 108.2347 440.4455 cm 0 0 m 0 0.464 0.372 0.835 0.836 0.835 c 1.3 0.835 1.672 0.464 1.672 0 c 1.672 -0.464 1.3 -0.835 0.836 -0.835 c 0.372 -0.835 0 -0.464 0 0 c h S Q q 1 0 0 1 110.4632 439.3322 cm 0 0 m 0 0.464 0.372 0.835 0.836 0.835 c 1.3 0.835 1.672 0.464 1.672 0 c 1.672 -0.464 1.3 -0.835 0.836 -0.835 c 0.372 -0.835 0 -0.464 0 0 c h S Q q 1 0 0 1 112.1349 437.6622 cm 0 0 m 0 0.464 0.372 0.835 0.836 0.835 c 1.3 0.835 1.672 0.464 1.672 0 c 1.672 -0.464 1.3 -0.835 0.836 -0.835 c 0.372 -0.835 0 -0.464 0 0 c h S Q q 1 0 0 1 112.1349 436.5489 cm 0 0 m 0 0.464 0.372 0.835 0.836 0.835 c 1.3 0.835 1.672 0.464 1.672 0 c 1.672 -0.464 1.3 -0.835 0.836 -0.835 c 0.372 -0.835 0 -0.464 0 0 c h S Q q 1 0 0 1 112.6918 434.8789 cm 0 0 m 0 0.464 0.372 0.835 0.836 0.835 c 1.3 0.835 1.672 0.464 1.672 0 c 1.672 -0.464 1.3 -0.835 0.836 -0.835 c 0.372 -0.835 0 -0.464 0 0 c h S Q q 1 0 0 1 113.249 433.7656 cm 0 0 m 0 0.464 0.372 0.835 0.836 0.835 c 1.3 0.835 1.672 0.464 1.672 0 c 1.672 -0.464 1.3 -0.835 0.836 -0.835 c 0.372 -0.835 0 -0.464 0 0 c h S Q q 1 0 0 1 113.249 432.0956 cm 0 0 m 0 0.464 0.372 0.835 0.836 0.835 c 1.3 0.835 1.672 0.464 1.672 0 c 1.672 -0.464 1.3 -0.835 0.836 -0.835 c 0.372 -0.835 0 -0.464 0 0 c h S Q q 1 0 0 1 113.249 430.9823 cm 0 0 m 0 0.464 0.372 0.835 0.836 0.835 c 1.3 0.835 1.672 0.464 1.672 0 c 1.672 -0.464 1.3 -0.835 0.836 -0.835 c 0.372 -0.835 0 -0.464 0 0 c h S Q q 1 0 0 1 113.249 429.3123 cm 0 0 m 0 0.464 0.372 0.835 0.836 0.835 c 1.3 0.835 1.672 0.464 1.672 0 c 1.672 -0.464 1.3 -0.835 0.836 -0.835 c 0.372 -0.835 0 -0.464 0 0 c h S Q q 1 0 0 1 113.8062 428.199 cm 0 0 m 0 0.464 0.372 0.835 0.836 0.835 c 1.3 0.835 1.672 0.464 1.672 0 c 1.672 -0.464 1.3 -0.835 0.836 -0.835 c 0.372 -0.835 0 -0.464 0 0 c h S Q q 1 0 0 1 115.4776 427.0862 cm 0 0 m 0 0.464 0.372 0.835 0.836 0.835 c 1.3 0.835 1.672 0.464 1.672 0 c 1.672 -0.464 1.3 -0.835 0.836 -0.835 c 0.372 -0.835 0 -0.464 0 0 c h S Q q 1 0 0 1 117.7061 425.4162 cm 0 0 m 0 0.464 0.372 0.835 0.836 0.835 c 1.3 0.835 1.672 0.464 1.672 0 c 1.672 -0.464 1.3 -0.835 0.836 -0.835 c 0.372 -0.835 0 -0.464 0 0 c h S Q q 1 0 0 1 119.3778 424.3029 cm 0 0 m 0 0.464 0.372 0.835 0.836 0.835 c 1.3 0.835 1.672 0.464 1.672 0 c 1.672 -0.464 1.3 -0.835 0.836 -0.835 c 0.372 -0.835 0 -0.464 0 0 c h S Q q 1 0 0 1 119.3778 422.6329 cm 0 0 m 0 0.464 0.372 0.835 0.836 0.835 c 1.3 0.835 1.672 0.464 1.672 0 c 1.672 -0.464 1.3 -0.835 0.836 -0.835 c 0.372 -0.835 0 -0.464 0 0 c h S Q q 1 0 0 1 119.9347 421.5196 cm 0 0 m 0 0.464 0.372 0.835 0.836 0.835 c 1.3 0.835 1.672 0.464 1.672 0 c 1.672 -0.464 1.3 -0.835 0.836 -0.835 c 0.372 -0.835 0 -0.464 0 0 c h S Q q 1 0 0 1 121.0491 419.8354 cm 0 0 m 0 0.472 0.372 0.849 0.836 0.849 c 1.3 0.849 1.672 0.472 1.672 0 c 1.672 -0.471 1.3 -0.849 0.836 -0.849 c 0.372 -0.849 0 -0.471 0 0 c h S Q q 1 0 0 1 122.7204 418.1518 cm 0 0 m 0 0.464 0.372 0.835 0.836 0.835 c 1.3 0.835 1.672 0.464 1.672 0 c 1.672 -0.464 1.3 -0.835 0.836 -0.835 c 0.372 -0.835 0 -0.464 0 0 c h S Q q 1 0 0 1 123.2776 417.0385 cm 0 0 m 0 0.464 0.372 0.835 0.836 0.835 c 1.3 0.835 1.672 0.464 1.672 0 c 1.672 -0.464 1.3 -0.835 0.836 -0.835 c 0.372 -0.835 0 -0.464 0 0 c h S Q q 1 0 0 1 124.3918 415.3685 cm 0 0 m 0 0.464 0.372 0.835 0.836 0.835 c 1.3 0.835 1.672 0.464 1.672 0 c 1.672 -0.464 1.3 -0.835 0.836 -0.835 c 0.372 -0.835 0 -0.464 0 0 c h S Q q 1 0 0 1 124.949 414.2552 cm 0 0 m 0 0.464 0.372 0.835 0.836 0.835 c 1.3 0.835 1.672 0.464 1.672 0 c 1.672 -0.464 1.3 -0.835 0.836 -0.835 c 0.372 -0.835 0 -0.464 0 0 c h S Q q 1 0 0 1 125.5062 412.5852 cm 0 0 m 0 0.464 0.372 0.835 0.836 0.835 c 1.3 0.835 1.672 0.464 1.672 0 c 1.672 -0.464 1.3 -0.835 0.836 -0.835 c 0.372 -0.835 0 -0.464 0 0 c h S Q q 1 0 0 1 128.292 411.4718 cm 0 0 m 0 0.464 0.372 0.835 0.836 0.835 c 1.3 0.835 1.672 0.464 1.672 0 c 1.672 -0.464 1.3 -0.835 0.836 -0.835 c 0.372 -0.835 0 -0.464 0 0 c h S Q q 1 0 0 1 128.8492 409.8019 cm 0 0 m 0 0.464 0.372 0.835 0.836 0.835 c 1.3 0.835 1.672 0.464 1.672 0 c 1.672 -0.464 1.3 -0.835 0.836 -0.835 c 0.372 -0.835 0 -0.464 0 0 c h S Q q 1 0 0 1 131.0777 408.1324 cm 0 0 m 0 0.464 0.372 0.835 0.836 0.835 c 1.3 0.835 1.672 0.464 1.672 0 c 1.672 -0.464 1.3 -0.835 0.836 -0.835 c 0.372 -0.835 0 -0.464 0 0 c h S Q q 1 0 0 1 133.3062 407.0191 cm 0 0 m 0 0.464 0.372 0.835 0.836 0.835 c 1.3 0.835 1.672 0.464 1.672 0 c 1.672 -0.464 1.3 -0.835 0.836 -0.835 c 0.372 -0.835 0 -0.464 0 0 c h S Q q 1 0 0 1 133.8632 405.3492 cm 0 0 m 0 0.464 0.372 0.835 0.836 0.835 c 1.3 0.835 1.672 0.464 1.672 0 c 1.672 -0.464 1.3 -0.835 0.836 -0.835 c 0.372 -0.835 0 -0.464 0 0 c h S Q q 1 0 0 1 138.8775 403.6791 cm 0 0 m 0 0.464 0.372 0.835 0.836 0.835 c 1.3 0.835 1.672 0.464 1.672 0 c 1.672 -0.464 1.3 -0.835 0.836 -0.835 c 0.372 -0.835 0 -0.464 0 0 c h S Q q 1 0 0 1 141.6633 402.0091 cm 0 0 m 0 0.464 0.372 0.835 0.836 0.835 c 1.3 0.835 1.672 0.464 1.672 0 c 1.672 -0.464 1.3 -0.835 0.836 -0.835 c 0.372 -0.835 0 -0.464 0 0 c h S Q q 1 0 0 1 142.2205 400.3391 cm 0 0 m 0 0.464 0.372 0.835 0.836 0.835 c 1.3 0.835 1.672 0.464 1.672 0 c 1.672 -0.464 1.3 -0.835 0.836 -0.835 c 0.372 -0.835 0 -0.464 0 0 c h S Q q 1 0 0 1 143.8918 398.6692 cm 0 0 m 0 0.464 0.372 0.835 0.836 0.835 c 1.3 0.835 1.672 0.464 1.672 0 c 1.672 -0.464 1.3 -0.835 0.836 -0.835 c 0.372 -0.835 0 -0.464 0 0 c h S Q q 1 0 0 1 145.5632 396.9992 cm 0 0 m 0 0.464 0.372 0.835 0.836 0.835 c 1.3 0.835 1.672 0.464 1.672 0 c 1.672 -0.464 1.3 -0.835 0.836 -0.835 c 0.372 -0.835 0 -0.464 0 0 c h S Q q 1 0 0 1 146.6776 395.3292 cm 0 0 m 0 0.464 0.372 0.835 0.836 0.835 c 1.3 0.835 1.672 0.464 1.672 0 c 1.672 -0.464 1.3 -0.835 0.836 -0.835 c 0.372 -0.835 0 -0.464 0 0 c h S Q q 1 0 0 1 166.7071 391.9756 cm 0 0 m 0 0.472 0.371 0.849 0.835 0.849 c 1.3 0.849 1.671 0.472 1.671 0 c 1.671 -0.472 1.3 -0.849 0.835 -0.849 c 0.371 -0.849 0 -0.472 0 0 c h S Q q 1 0 0 1 167.2643 388.622 cm 0 0 m 0 0.464 0.371 0.835 0.835 0.835 c 1.3 0.835 1.671 0.464 1.671 0 c 1.671 -0.464 1.3 -0.835 0.835 -0.835 c 0.371 -0.835 0 -0.464 0 0 c h S Q Q 0 0 0 1 K 0.557 w /GS1 gs q 1 0 0 1 62.577 369.9741 cm 0 0 m 194.916 0 l S Q q 1 0 0 1 62.577 371.0875 cm 0 0 m 0 -1.113 l S Q q 1 0 0 1 95.0585 371.0875 cm 0 0 m 0 -1.113 l S Q q 1 0 0 1 127.5397 371.0875 cm 0 0 m 0 -1.113 l S Q q 1 0 0 1 160.0212 371.0875 cm 0 0 m 0 -1.113 l S Q q 1 0 0 1 192.5024 371.0875 cm 0 0 m 0 -1.113 l S Q q 1 0 0 1 224.9842 371.0875 cm 0 0 m 0 -1.113 l S Q q 1 0 0 1 257.4932 371.0875 cm 0 0 m 0 -1.113 l S Q q 1 0 0 1 69.0675 370.5308 cm 0 0 m 0 -0.557 l S Q q 1 0 0 1 75.5584 370.5308 cm 0 0 m 0 -0.557 l S Q q 1 0 0 1 82.049 370.5308 cm 0 0 m 0 -0.557 l S Q q 1 0 0 1 88.5398 370.5308 cm 0 0 m 0 -0.557 l S Q q 1 0 0 1 95.0585 370.5308 cm 0 0 m 0 -0.557 l S Q q 1 0 0 1 101.549 370.5308 cm 0 0 m 0 -0.557 l S Q q 1 0 0 1 108.0399 370.5308 cm 0 0 m 0 -0.557 l S Q q 1 0 0 1 114.5305 370.5308 cm 0 0 m 0 -0.557 l S Q q 1 0 0 1 121.0491 370.5308 cm 0 0 m 0 -0.557 l S Q q 1 0 0 1 127.5397 370.5308 cm 0 0 m 0 -0.557 l S Q q 1 0 0 1 134.0305 370.5308 cm 0 0 m 0 -0.557 l S Q q 1 0 0 1 140.5211 370.5308 cm 0 0 m 0 -0.557 l S Q q 1 0 0 1 147.0397 370.5308 cm 0 0 m 0 -0.557 l S Q q 1 0 0 1 153.5306 370.5308 cm 0 0 m 0 -0.557 l S Q q 1 0 0 1 160.0212 370.5308 cm 0 0 m 0 -0.557 l S Q q 1 0 0 1 166.5117 370.5308 cm 0 0 m 0 -0.557 l S Q q 1 0 0 1 173.0029 370.5308 cm 0 0 m 0 -0.557 l S Q q 1 0 0 1 179.5213 370.5308 cm 0 0 m 0 -0.557 l S Q q 1 0 0 1 186.0118 370.5308 cm 0 0 m 0 -0.557 l S Q q 1 0 0 1 192.5024 370.5308 cm 0 0 m 0 -0.557 l S Q q 1 0 0 1 198.9935 370.5308 cm 0 0 m 0 -0.557 l S Q q 1 0 0 1 205.5119 370.5308 cm 0 0 m 0 -0.557 l S Q q 1 0 0 1 212.0024 370.5308 cm 0 0 m 0 -0.557 l S Q q 1 0 0 1 218.4936 370.5308 cm 0 0 m 0 -0.557 l S Q q 1 0 0 1 224.9842 370.5308 cm 0 0 m 0 -0.557 l S Q q 1 0 0 1 231.5025 370.5308 cm 0 0 m 0 -0.557 l S Q q 1 0 0 1 237.9931 370.5308 cm 0 0 m 0 -0.557 l S Q q 1 0 0 1 244.4843 370.5308 cm 0 0 m 0 -0.557 l S Q q 1 0 0 1 250.9748 370.5308 cm 0 0 m 0 -0.557 l S Q q 1 0 0 1 257.4932 370.5308 cm 0 0 m 0 -0.557 l S Q BT 0 0 0 1 k /TT1 1 Tf 4.495 0 0 4.648 59.5123 363.5488 Tm (-)Tj 0.371 0 Td (2)Tj 0.496 0 Td (0)Tj 6.793 0 Td (0)Tj 6.978 0 Td (2)Tj 0.496 0 Td (0)Tj 6.729 0 Td (4)Tj 0.496 0 Td (0)Tj 6.73 0 Td (6)Tj 0.496 0 Td (0)Tj 6.73 0 Td (8)Tj 0.496 0 Td (0)Tj 6.488 0 Td (1)Tj 0.496 0 Td (0)Tj 0.496 0 Td (0)Tj /C2_1 1 Tf -30.052 -1.858 Td <023C>Tj 0.62 0 Td <026A>Tj 0.496 0 Td <025F>Tj 0.496 0 Td <0266>Tj 0.744 0 Td <0279>Tj /TT1 1 Tf 0.496 0 Td ( )Tj /C2_1 1 Tf 0.249 0 Td <0268>Tj 0.496 0 Td <026C>Tj /TT1 1 Tf 0.495 0 Td ( )Tj /C2_1 1 Tf 0.249 0 Td <0269>Tj 0.497 0 Td <026A>Tj 0.496 0 Td <0268>Tj 0.496 0 Td <025C>Tj 0.496 0 Td <025F>Tj 0.496 0 Td <025E>Tj 0.62 0 Td <025F>Tj 0.496 0 Td <0267>Tj 0.49 0 Td <0262>Tj 0.497 0 Td <0279>Tj /TT1 1 Tf 0.497 0 Td ( )Tj /C2_1 1 Tf 0.249 0 Td <0268>Tj 0.496 0 Td <0269>Tj 0.496 0 Td <025F>Tj 0.496 0 Td <026A>Tj 0.496 0 Td <025A>Tj 0.496 0 Td <0270>Tj 0.619 0 Td <0262>Tj 0.497 0 Td <0262>Tj /TT1 1 Tf 0.497 0 Td (,)Tj 0.249 0 Td ( )Tj /C2_1 1 Tf 0.249 0 Td <0266>Tj 0.744 0 Td <025F>Tj 0.496 0 Td <026B>Tj /TT1 1 Tf 0.496 0 Td (.)Tj ET q 1 0 0 1 62.577 496.4437 cm 0 0 m 194.916 0 l S Q q 1 0 0 1 71.8533 495.3026 cm 0 0 m 0 1.141 l S Q q 1 0 0 1 108.9589 495.3026 cm 0 0 m 0 1.141 l S Q q 1 0 0 1 146.0927 495.3026 cm 0 0 m 0 1.141 l S Q q 1 0 0 1 183.2263 495.3026 cm 0 0 m 0 1.141 l S Q q 1 0 0 1 220.36 495.3026 cm 0 0 m 0 1.141 l S Q q 1 0 0 1 257.4932 495.3026 cm 0 0 m 0 1.141 l S Q q 1 0 0 1 64.4153 495.8593 cm 0 0 m 0 0.585 l S Q q 1 0 0 1 71.8533 495.8593 cm 0 0 m 0 0.585 l S Q q 1 0 0 1 79.2632 495.8593 cm 0 0 m 0 0.585 l S Q q 1 0 0 1 86.7012 495.8593 cm 0 0 m 0 0.585 l S Q q 1 0 0 1 94.1111 495.8593 cm 0 0 m 0 0.585 l S Q q 1 0 0 1 101.549 495.8593 cm 0 0 m 0 0.585 l S Q q 1 0 0 1 108.9589 495.8593 cm 0 0 m 0 0.585 l S Q q 1 0 0 1 116.3969 495.8593 cm 0 0 m 0 0.585 l S Q q 1 0 0 1 123.8349 495.8593 cm 0 0 m 0 0.585 l S Q q 1 0 0 1 131.2448 495.8593 cm 0 0 m 0 0.585 l S Q q 1 0 0 1 138.6827 495.8593 cm 0 0 m 0 0.585 l S Q q 1 0 0 1 146.0927 495.8593 cm 0 0 m 0 0.585 l S Q q 1 0 0 1 153.5306 495.8593 cm 0 0 m 0 0.585 l S Q q 1 0 0 1 160.9402 495.8593 cm 0 0 m 0 0.585 l S Q q 1 0 0 1 168.3782 495.8593 cm 0 0 m 0 0.585 l S Q q 1 0 0 1 175.7884 495.8593 cm 0 0 m 0 0.585 l S Q q 1 0 0 1 183.2263 495.8593 cm 0 0 m 0 0.585 l S Q q 1 0 0 1 190.6643 495.8593 cm 0 0 m 0 0.585 l S Q q 1 0 0 1 198.0739 495.8593 cm 0 0 m 0 0.585 l S Q q 1 0 0 1 205.5119 495.8593 cm 0 0 m 0 0.585 l S Q q 1 0 0 1 212.9221 495.8593 cm 0 0 m 0 0.585 l S Q q 1 0 0 1 220.36 495.8593 cm 0 0 m 0 0.585 l S Q q 1 0 0 1 227.7697 495.8593 cm 0 0 m 0 0.585 l S Q q 1 0 0 1 235.2076 495.8593 cm 0 0 m 0 0.585 l S Q q 1 0 0 1 242.6178 495.8593 cm 0 0 m 0 0.585 l S Q q 1 0 0 1 250.0552 495.8593 cm 0 0 m 0 0.585 l S Q q 1 0 0 1 257.4932 495.8593 cm 0 0 m 0 0.585 l S Q q 1 0 0 1 62.577 369.9741 cm 0 0 m 0 126.47 l S Q q 1 0 0 1 63.6633 369.9741 cm 0 0 m -1.087 0 l S Q q 1 0 0 1 63.6633 381.4687 cm 0 0 m -1.087 0 l S Q q 1 0 0 1 63.6633 392.9638 cm 0 0 m -1.087 0 l S Q q 1 0 0 1 63.6633 404.4583 cm 0 0 m -1.087 0 l S Q q 1 0 0 1 63.6633 415.9529 cm 0 0 m -1.087 0 l S Q q 1 0 0 1 63.6633 427.448 cm 0 0 m -1.087 0 l S Q q 1 0 0 1 63.6633 438.9426 cm 0 0 m -1.087 0 l S Q q 1 0 0 1 63.6633 450.4371 cm 0 0 m -1.087 0 l S Q q 1 0 0 1 63.6633 461.9317 cm 0 0 m -1.087 0 l S Q q 1 0 0 1 63.6633 473.4265 cm 0 0 m -1.087 0 l S Q q 1 0 0 1 63.6633 484.9214 cm 0 0 m -1.087 0 l S Q q 1 0 0 1 63.6633 496.4159 cm 0 0 m -1.087 0 l S Q q 1 0 0 1 63.1061 372.8407 cm 0 0 m -0.529 0 l S Q q 1 0 0 1 63.1061 375.7078 cm 0 0 m -0.529 0 l S Q q 1 0 0 1 63.1061 378.5744 cm 0 0 m -0.529 0 l S Q q 1 0 0 1 63.1061 381.4687 cm 0 0 m -0.529 0 l S Q q 1 0 0 1 63.1061 384.3358 cm 0 0 m -0.529 0 l S Q q 1 0 0 1 63.1061 387.2024 cm 0 0 m -0.529 0 l S Q q 1 0 0 1 63.1061 390.0689 cm 0 0 m -0.529 0 l S Q q 1 0 0 1 63.1061 392.9638 cm 0 0 m -0.529 0 l S Q q 1 0 0 1 63.1061 395.8303 cm 0 0 m -0.529 0 l S Q q 1 0 0 1 63.1061 398.6969 cm 0 0 m -0.529 0 l S Q q 1 0 0 1 63.1061 401.564 cm 0 0 m -0.529 0 l S Q q 1 0 0 1 63.1061 404.4583 cm 0 0 m -0.529 0 l S Q q 1 0 0 1 63.1061 407.325 cm 0 0 m -0.529 0 l S Q q 1 0 0 1 63.1061 410.192 cm 0 0 m -0.529 0 l S Q q 1 0 0 1 63.1061 413.0864 cm 0 0 m -0.529 0 l S Q q 1 0 0 1 63.1061 415.9529 cm 0 0 m -0.529 0 l S Q q 1 0 0 1 63.1061 418.82 cm 0 0 m -0.529 0 l S Q q 1 0 0 1 63.1061 421.6866 cm 0 0 m -0.529 0 l S Q q 1 0 0 1 63.1061 424.5809 cm 0 0 m -0.529 0 l S Q q 1 0 0 1 63.1061 427.448 cm 0 0 m -0.529 0 l S Q q 1 0 0 1 63.1061 430.3146 cm 0 0 m -0.529 0 l S Q q 1 0 0 1 63.1061 433.1812 cm 0 0 m -0.529 0 l S Q q 1 0 0 1 63.1061 436.0757 cm 0 0 m -0.529 0 l S Q q 1 0 0 1 63.1061 438.9426 cm 0 0 m -0.529 0 l S Q q 1 0 0 1 63.1061 441.8091 cm 0 0 m -0.529 0 l S Q q 1 0 0 1 63.1061 444.7038 cm 0 0 m -0.529 0 l S Q q 1 0 0 1 63.1061 447.5706 cm 0 0 m -0.529 0 l S Q q 1 0 0 1 63.1061 450.4371 cm 0 0 m -0.529 0 l S Q q 1 0 0 1 63.1061 453.304 cm 0 0 m -0.529 0 l S Q q 1 0 0 1 63.1061 456.1983 cm 0 0 m -0.529 0 l S Q q 1 0 0 1 63.1061 459.0652 cm 0 0 m -0.529 0 l S Q q 1 0 0 1 63.1061 461.9317 cm 0 0 m -0.529 0 l S Q q 1 0 0 1 63.1061 464.7985 cm 0 0 m -0.529 0 l S Q q 1 0 0 1 63.1061 467.6932 cm 0 0 m -0.529 0 l S Q q 1 0 0 1 63.1061 470.5597 cm 0 0 m -0.529 0 l S Q q 1 0 0 1 63.1061 473.4265 cm 0 0 m -0.529 0 l S Q q 1 0 0 1 63.1061 476.3211 cm 0 0 m -0.529 0 l S Q q 1 0 0 1 63.1061 479.1877 cm 0 0 m -0.529 0 l S Q q 1 0 0 1 63.1061 482.0546 cm 0 0 m -0.529 0 l S Q q 1 0 0 1 63.1061 484.9214 cm 0 0 m -0.529 0 l S Q q 1 0 0 1 63.1061 487.8157 cm 0 0 m -0.529 0 l S Q q 1 0 0 1 63.1061 490.6826 cm 0 0 m -0.529 0 l S Q q 1 0 0 1 63.1061 493.5494 cm 0 0 m -0.529 0 l S Q q 1 0 0 1 63.1061 496.4159 cm 0 0 m -0.529 0 l S Q BT /TT1 1 Tf 4.495 0 0 4.648 54.7761 368.5811 Tm (0)Tj 0.496 0 Td (,)Tj 0.249 0 Td (1)Tj -0.745 2.474 Td (0)Tj 0.496 0 Td (,)Tj 0.249 0 Td (2)Tj -0.745 2.473 Td (0)Tj 0.496 0 Td (,)Tj 0.249 0 Td (3)Tj -0.745 2.473 Td (0)Tj 0.496 0 Td (,)Tj 0.249 0 Td (4)Tj -0.745 2.473 Td (0)Tj 0.496 0 Td (,)Tj 0.249 0 Td (5)Tj -0.745 2.473 Td (0)Tj 0.496 0 Td (,)Tj 0.249 0 Td (6)Tj -0.745 2.474 Td (0)Tj 0.496 0 Td (,)Tj 0.249 0 Td (7)Tj -0.745 2.473 Td (0)Tj 0.496 0 Td (,)Tj 0.249 0 Td (8)Tj -0.745 2.473 Td (0)Tj 0.496 0 Td (,)Tj 0.249 0 Td (9)Tj -0.745 2.473 Td (1)Tj 0.496 0 Td (,)Tj 0.249 0 Td (0)Tj -0.745 2.474 Td (1)Tj 0.496 0 Td (,)Tj 0.249 0 Td (1)Tj -0.745 2.473 Td (1)Tj 0.496 0 Td (,)Tj 0.249 0 Td (2)Tj /C2_1 1 Tf 0 4.648 -4.6521 0 49.7614 399.2233 Tm <0244>Tj 0.598 0 Td <026D>Tj 0.48 0 Td <0266>Tj 0.719 0 Td <026D>Tj 0.48 0 Td <0265>Tj 0.598 0 Td <0279>Tj 0.604 0 Td <026C>Tj 0.479 0 Td <0262>Tj 0.599 0 Td <025C>Tj 0.479 0 Td <0267>Tj 0.598 0 Td <025A>Tj 0.598 0 Td <0279>Tj /TT1 1 Tf 0.598 0 Td ( )Tj /C2_1 1 Tf 0.24 0 Td <025E>Tj 0.598 0 Td <0268>Tj 0.598 0 Td <0265>Tj 0.598 0 Td <0279>Tj /TT1 1 Tf 0.604 0 Td ( )Tj /C2_1 1 Tf 0.24 0 Td <025C>Tj 0.479 0 Td <0275>Tj <0260>Tj 1.437 0 Td <0262>Tj 0.599 0 Td <025C>Tj 0.479 0 Td <0272>Tj 0.838 0 Td <0262>Tj 0.599 0 Td <026F>Tj ET q 1 0 0 1 257.4932 369.9741 cm 0 0 m 0 126.47 l S Q q 1 0 0 1 256.3793 369.9741 cm 0 0 m 1.114 0 l S Q q 1 0 0 1 256.3793 381.4687 cm 0 0 m 1.114 0 l S Q q 1 0 0 1 256.3793 392.9638 cm 0 0 m 1.114 0 l S Q q 1 0 0 1 256.3793 404.4583 cm 0 0 m 1.114 0 l S Q q 1 0 0 1 256.3793 415.9529 cm 0 0 m 1.114 0 l S Q q 1 0 0 1 256.3793 427.448 cm 0 0 m 1.114 0 l S Q q 1 0 0 1 256.3793 438.9426 cm 0 0 m 1.114 0 l S Q q 1 0 0 1 256.3793 450.4371 cm 0 0 m 1.114 0 l S Q q 1 0 0 1 256.3793 461.9317 cm 0 0 m 1.114 0 l S Q q 1 0 0 1 256.3793 473.4265 cm 0 0 m 1.114 0 l S Q q 1 0 0 1 256.3793 484.9214 cm 0 0 m 1.114 0 l S Q q 1 0 0 1 256.3793 496.4159 cm 0 0 m 1.114 0 l S Q q 1 0 0 1 256.936 372.8407 cm 0 0 m 0.557 0 l S Q q 1 0 0 1 256.936 375.7078 cm 0 0 m 0.557 0 l S Q q 1 0 0 1 256.936 378.5744 cm 0 0 m 0.557 0 l S Q q 1 0 0 1 256.936 381.4687 cm 0 0 m 0.557 0 l S Q q 1 0 0 1 256.936 384.3358 cm 0 0 m 0.557 0 l S Q q 1 0 0 1 256.936 387.2024 cm 0 0 m 0.557 0 l S Q q 1 0 0 1 256.936 390.0689 cm 0 0 m 0.557 0 l S Q q 1 0 0 1 256.936 392.9638 cm 0 0 m 0.557 0 l S Q q 1 0 0 1 256.936 395.8303 cm 0 0 m 0.557 0 l S Q q 1 0 0 1 256.936 398.6969 cm 0 0 m 0.557 0 l S Q q 1 0 0 1 256.936 401.564 cm 0 0 m 0.557 0 l S Q q 1 0 0 1 256.936 404.4583 cm 0 0 m 0.557 0 l S Q q 1 0 0 1 256.936 407.325 cm 0 0 m 0.557 0 l S Q q 1 0 0 1 256.936 410.192 cm 0 0 m 0.557 0 l S Q q 1 0 0 1 256.936 413.0864 cm 0 0 m 0.557 0 l S Q q 1 0 0 1 256.936 415.9529 cm 0 0 m 0.557 0 l S Q q 1 0 0 1 256.936 418.82 cm 0 0 m 0.557 0 l S Q q 1 0 0 1 256.936 421.6866 cm 0 0 m 0.557 0 l S Q q 1 0 0 1 256.936 424.5809 cm 0 0 m 0.557 0 l S Q q 1 0 0 1 256.936 427.448 cm 0 0 m 0.557 0 l S Q q 1 0 0 1 256.936 430.3146 cm 0 0 m 0.557 0 l S Q q 1 0 0 1 256.936 433.1812 cm 0 0 m 0.557 0 l S Q q 1 0 0 1 256.936 436.0757 cm 0 0 m 0.557 0 l S Q q 1 0 0 1 256.936 438.9426 cm 0 0 m 0.557 0 l S Q q 1 0 0 1 256.936 441.8091 cm 0 0 m 0.557 0 l S Q q 1 0 0 1 256.936 444.7038 cm 0 0 m 0.557 0 l S Q q 1 0 0 1 256.936 447.5706 cm 0 0 m 0.557 0 l S Q q 1 0 0 1 256.936 450.4371 cm 0 0 m 0.557 0 l S Q q 1 0 0 1 256.936 453.304 cm 0 0 m 0.557 0 l S Q q 1 0 0 1 256.936 456.1983 cm 0 0 m 0.557 0 l S Q q 1 0 0 1 256.936 459.0652 cm 0 0 m 0.557 0 l S Q q 1 0 0 1 256.936 461.9317 cm 0 0 m 0.557 0 l S Q q 1 0 0 1 256.936 464.7985 cm 0 0 m 0.557 0 l S Q q 1 0 0 1 256.936 467.6932 cm 0 0 m 0.557 0 l S Q q 1 0 0 1 256.936 470.5597 cm 0 0 m 0.557 0 l S Q q 1 0 0 1 256.936 473.4265 cm 0 0 m 0.557 0 l S Q q 1 0 0 1 256.936 476.3211 cm 0 0 m 0.557 0 l S Q q 1 0 0 1 256.936 479.1877 cm 0 0 m 0.557 0 l S Q q 1 0 0 1 256.936 482.0546 cm 0 0 m 0.557 0 l S Q q 1 0 0 1 256.936 484.9214 cm 0 0 m 0.557 0 l S Q q 1 0 0 1 256.936 487.8157 cm 0 0 m 0.557 0 l S Q q 1 0 0 1 256.936 490.6826 cm 0 0 m 0.557 0 l S Q q 1 0 0 1 256.936 493.5494 cm 0 0 m 0.557 0 l S Q q 1 0 0 1 256.936 496.4159 cm 0 0 m 0.557 0 l S Q EMC BT 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0.046 Tw 9 0 0 9 42.5197 340.0735 Tm [(\022\t\217\210\b\002\220 )0.6(2.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf [( )0.5(\213\031\t\t\n\005\020\024\025\017\021\026\002 )0.7(\027\020\204\025\027\026\031\003\n\t\024\022 )0.6(\005\n\023\022\021\020\004 )0.5(\003\031\024\026)]TJ 0 Tw (-)Tj T* (\t\024\026\024\025\006\031\t\013\025\003 \032\026\013\n\003 \033\032\002\ \003\n\017 \013\025\001\013\025)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0.017 Tw T* [(F)-16(igure )0.5(2)16(.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf [( )0.5(Ev)13(ent-free )0.5(sur)-42(viv)16(al )0.5(of )0.5(patients )0.5(with )0.5(metastatic )0.5(rectal )]TJ 0 Tw T* (cancer)Tj ET 0 0 0 0 k /GS0 gs 42.52 133.396 221.102 163.773 re f /PlacedPDF /MC2 BDC 0 0.008 0.049 0 k 42.52 133.396 221.102 163.773 re f BT 0 0 0 1 k /GS1 gs /C2_2 1 Tf 4.495 0 0 -4.6535 106.5614 141.7089 Tm <0244>Tj 0.62 0 Td <026D>Tj 0.372 0 Td <0266>Tj 0.744 0 Td <026D>Tj 0.372 0 Td <0265>Tj 0.62 0 Td <0279>Tj 0.497 0 Td <026C>Tj 0.495 0 Td <0262>Tj 0.497 0 Td <025C>Tj 0.496 0 Td <0267>Tj 0.496 0 Td <025A>Tj 0.496 0 Td <0279>Tj /TT2 1 Tf 0.497 0 Td ( )Tj /C2_2 1 Tf 0.249 0 Td <025E>Tj 0.62 0 Td <0268>Tj 0.496 0 Td <0265>Tj 0.62 0 Td <0279>Tj /TT2 1 Tf 0.491 0 Td ( )Tj /C2_2 1 Tf 0.249 0 Td <025C>Tj 0.496 0 Td <0275>Tj 0.743 0 Td <0260>Tj 0.62 0 Td <0262>Tj 0.497 0 Td <025C>Tj 0.496 0 Td <0272>Tj 0.744 0 Td <0262>Tj 0.497 0 Td <026F>Tj /TT2 1 Tf 0.372 0 Td ( )Tj 0.249 0 Td (\()Tj /C2_2 1 Tf 0.371 0 Td <0244>Tj 0.619 0 Td <025A>Tj 0.496 0 Td <0269>Tj 0.496 0 Td <0265>Tj 0.619 0 Td <025A>Tj 0.496 0 Td <0267>Tj /TT2 1 Tf 0.496 0 Td (-)Tj /C2_2 1 Tf 0.371 0 Td <0246>Tj 0.867 0 Td <025F>Tj 0.496 0 Td <0263>Tj 0.497 0 Td <025F>Tj 0.496 0 Td <026A>Tj /TT2 1 Tf 0.496 0 Td (\))Tj ET q 42.52 133.396 221.102 163.773 re W n 0.884 0.769 0 0 K 0.557 w /GS0 gs q 1 0 0 1 128.292 147.0046 cm 0 0 m 0 -0.464 0.372 -0.836 0.836 -0.836 c 1.3 -0.836 1.672 -0.464 1.672 0 c 1.672 0.464 1.3 0.836 0.836 0.836 c 0.372 0.836 0 0.464 0 0 c h S Q Q BT /C2_2 1 Tf 4.495 0 0 -4.6535 133.8341 148.9526 Tm <0241>Tj 0.619 0 Td <025A>Tj 0.496 0 Td <025C>Tj 0.496 0 Td <025F>Tj 0.496 0 Td <026A>Tj 0.496 0 Td <0272>Tj /TT2 1 Tf 0.744 0 Td (.)Tj 0.249 0 Td ( )Tj 0.249 0 Td ( )Tj 0.249 0 Td ( )Tj ET 0.884 0.769 0 0 k /GS0 gs q 1 0 0 1 156.6783 147.2832 cm 0 0 m 2.228 0 l h f Q 0.884 0.769 0 0 K 0.279 w q 1 0 0 1 156.6785 147.2834 cm 0 0 m 2.228 0 l 0 0 l h S Q q 1 0 0 1 157.7925 146.169 cm 0 0 m 0 2.228 l h f Q q 1 0 0 1 157.7929 146.1688 cm 0 0 m 0 0 l 0 2.229 l 0 0 l h S Q BT 0 0 0 1 k /GS1 gs /C2_2 1 Tf 4.495 0 0 -4.6535 162.6129 148.9526 Tm <0250>Tj 0.743 0 Td <025F>Tj 0.496 0 Td <0267>Tj 0.496 0 Td <0261>Tj 0.495 0 Td <026D>Tj 0.372 0 Td <026A>Tj 0.496 0 Td <0262>Tj 0.497 0 Td <026A>Tj /TT2 1 Tf 0.496 0 Td (.)Tj ET 0 0 0 0 k /GS0 gs 64.249 153.414 194.916 125.365 re f* 0 0 0 0.25 K q 1 0 0 1 68.984 278.2213 cm 0 0 m 0 -124.808 l S Q q 1 0 0 1 87.9268 278.2213 cm 0 0 m 0 -124.808 l S Q q 1 0 0 1 106.8977 278.2213 cm 0 0 m 0 -124.808 l S Q q 1 0 0 1 125.8683 278.2213 cm 0 0 m 0 -124.808 l S Q q 1 0 0 1 144.8112 278.2213 cm 0 0 m 0 -124.808 l S Q q 1 0 0 1 163.7818 278.2213 cm 0 0 m 0 -124.808 l S Q q 1 0 0 1 182.7524 278.2213 cm 0 0 m 0 -124.808 l S Q q 1 0 0 1 201.6952 278.2213 cm 0 0 m 0 -124.808 l S Q q 1 0 0 1 220.6664 278.2213 cm 0 0 m 0 -124.808 l S Q q 1 0 0 1 239.637 278.2213 cm 0 0 m 0 -124.808 l S Q q 1 0 0 1 64.2483 267.3819 cm 0 0 m 194.359 0 l S Q q 1 0 0 1 64.2483 256.5425 cm 0 0 m 194.359 0 l S Q q 1 0 0 1 64.2483 245.6748 cm 0 0 m 194.359 0 l S Q q 1 0 0 1 64.2483 234.8354 cm 0 0 m 194.359 0 l S Q q 1 0 0 1 64.2483 223.9677 cm 0 0 m 194.359 0 l S Q q 1 0 0 1 64.2483 213.1285 cm 0 0 m 194.359 0 l S Q q 1 0 0 1 64.2483 202.2611 cm 0 0 m 194.359 0 l S Q q 1 0 0 1 64.2483 191.4217 cm 0 0 m 194.359 0 l S Q q 1 0 0 1 64.2483 180.5543 cm 0 0 m 194.359 0 l S Q q 1 0 0 1 64.2483 169.7148 cm 0 0 m 194.359 0 l S Q q 1 0 0 1 64.2483 158.8474 cm 0 0 m 194.359 0 l S Q 0.884 0.769 0 0 K 0.557 w q 1 0 0 1 68.984 158.8474 cm 0 0 m 0.418 0 l 0.418 2.09 l 3.483 2.09 l 3.483 4.18 l 3.622 4.18 l 3.622 6.27 l 5.906 6.27 l 5.906 8.359 l 7.048 8.359 l 7.048 10.449 l 7.605 10.449 l 7.605 12.539 l 9.583 12.539 l 9.583 14.629 l 10.474 14.629 l 10.474 16.691 l 11.032 16.691 l 11.032 18.781 l 11.895 18.781 l 11.895 20.871 l 16.77 20.871 l 16.77 22.961 l 16.965 22.961 l 16.965 25.051 l 19.026 25.051 l 19.026 27.14 l 21.45 27.14 l 21.45 29.23 l 21.45 31.32 l 23.706 31.32 l 23.706 33.41 l 26.074 33.41 l 26.074 35.5 l 27.495 35.5 l 27.495 37.562 l 31.618 37.562 l 31.618 39.652 l 40.839 39.652 l 40.839 41.742 l 48.778 41.742 l 48.778 43.971 l 53.569 43.971 l 53.569 46.284 l 56.327 46.284 l 56.327 48.597 l 56.94 48.597 l 56.94 50.993 l 61.48 50.993 l 61.48 54.003 l 61.926 54.003 l 61.926 57.04 l 66.105 57.04 l 66.105 60.272 l 68.668 60.272 l 68.668 63.978 l 69.837 63.978 l 73.404 63.978 l 74.657 63.978 l 75.66 63.978 l 76.718 63.978 l 103.907 63.978 l 113.379 63.978 l 126.249 63.978 l 136.974 63.978 l 141.152 63.978 l 141.403 63.978 l 166.669 63.978 l S Q 0.884 0.769 0 0 k q 1 0 0 1 109.9062 200.7846 cm 0 0 m 2.229 0 l h f Q 0.279 w q 1 0 0 1 109.9063 200.7843 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 111.0204 199.6695 cm 0 0 m 0 2.229 l h f Q q 1 0 0 1 111.0204 199.6696 cm 0 0 m 0 0 l 0 2.229 l 0 0 l h S Q q 1 0 0 1 111.0204 200.7846 cm 0 0 m 2.229 0 l h f Q q 1 0 0 1 111.0204 200.7843 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 112.1346 199.6695 cm 0 0 m 0 2.229 l h f Q q 1 0 0 1 112.1349 199.6696 cm 0 0 m 0 0 l 0 2.229 l 0 0 l h S Q q 1 0 0 1 118.8207 203.013 cm 0 0 m 2.228 0 l h f Q q 1 0 0 1 118.8206 203.0134 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 119.9349 201.8988 cm 0 0 m 0 2.229 l h f Q q 1 0 0 1 119.9347 201.899 cm 0 0 m 0 0 l 0 2.229 l 0 0 l h S Q q 1 0 0 1 124.3917 207.4716 cm 0 0 m 2.229 0 l h f Q q 1 0 0 1 124.3918 207.4719 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 125.5059 206.3574 cm 0 0 m 0 2.229 l h f Q q 1 0 0 1 125.5062 206.3572 cm 0 0 m 0 0 l 0 2.229 l 0 0 l h S Q q 1 0 0 1 124.9488 209.7009 cm 0 0 m 2.229 0 l h f Q q 1 0 0 1 124.949 209.7012 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 126.063 208.5867 cm 0 0 m 0 2.228 l h f Q q 1 0 0 1 126.0634 208.5865 cm 0 0 m 0 0 l 0 2.229 l 0 0 l h S Q q 1 0 0 1 124.9488 209.7009 cm 0 0 m 2.229 0 l h f Q q 1 0 0 1 124.949 209.7012 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 126.063 208.5867 cm 0 0 m 0 2.228 l h f Q q 1 0 0 1 126.0634 208.5865 cm 0 0 m 0 0 l 0 2.229 l 0 0 l h S Q q 1 0 0 1 126.6201 209.7009 cm 0 0 m 2.229 0 l h f Q q 1 0 0 1 126.6203 209.7012 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 127.7343 208.5867 cm 0 0 m 0 2.228 l h f Q q 1 0 0 1 127.7347 208.5865 cm 0 0 m 0 0 l 0 2.229 l 0 0 l h S Q q 1 0 0 1 126.6201 209.7009 cm 0 0 m 2.229 0 l h f Q q 1 0 0 1 126.6203 209.7012 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 127.7343 208.5867 cm 0 0 m 0 2.228 l h f Q q 1 0 0 1 127.7347 208.5865 cm 0 0 m 0 0 l 0 2.229 l 0 0 l h S Q q 1 0 0 1 128.2923 209.7009 cm 0 0 m 2.228 0 l h f Q q 1 0 0 1 128.292 209.7012 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 129.4065 208.5867 cm 0 0 m 0 2.228 l h f Q q 1 0 0 1 129.4061 208.5865 cm 0 0 m 0 0 l 0 2.229 l 0 0 l h S Q q 1 0 0 1 132.7491 215.8038 cm 0 0 m 2.228 0 l h f Q q 1 0 0 1 132.749 215.8035 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 133.8633 214.7166 cm 0 0 m 0 2.201 l h f Q q 1 0 0 1 133.8632 214.7169 cm 0 0 m 0 0 l 0 2.201 l 0 0 l h S Q q 1 0 0 1 135.5346 219.1473 cm 0 0 m 2.229 0 l h f Q q 1 0 0 1 135.5349 219.1476 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 136.6488 218.0331 cm 0 0 m 0 2.229 l h f Q q 1 0 0 1 136.649 218.0332 cm 0 0 m 0 0 l 0 2.229 l 0 0 l h S Q q 1 0 0 1 136.0917 219.1473 cm 0 0 m 2.229 0 l h f Q q 1 0 0 1 136.0918 219.1476 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 137.2059 218.0331 cm 0 0 m 0 2.229 l h f Q q 1 0 0 1 137.2062 218.0332 cm 0 0 m 0 0 l 0 2.229 l 0 0 l h S Q q 1 0 0 1 137.763 223.0479 cm 0 0 m 2.229 0 l h f Q q 1 0 0 1 137.7634 223.0481 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 138.8772 221.9337 cm 0 0 m 0 2.23 l h f Q q 1 0 0 1 138.8775 221.9337 cm 0 0 m 0 0 l 0 2.23 l 0 0 l h S Q q 1 0 0 1 141.1065 223.0479 cm 0 0 m 2.228 0 l h f Q q 1 0 0 1 141.1061 223.0481 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 142.2207 221.9337 cm 0 0 m 0 2.23 l h f Q q 1 0 0 1 142.2205 221.9337 cm 0 0 m 0 0 l 0 2.23 l 0 0 l h S Q q 1 0 0 1 142.7778 223.0479 cm 0 0 m 2.228 0 l h f Q q 1 0 0 1 142.7777 223.0481 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 143.892 221.9337 cm 0 0 m 0 2.23 l h f Q q 1 0 0 1 143.8918 221.9337 cm 0 0 m 0 0 l 0 2.23 l 0 0 l h S Q q 1 0 0 1 143.3349 223.0479 cm 0 0 m 2.228 0 l h f Q q 1 0 0 1 143.3346 223.0481 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 144.4491 221.9337 cm 0 0 m 0 2.23 l h f Q q 1 0 0 1 144.449 221.9337 cm 0 0 m 0 0 l 0 2.23 l 0 0 l h S Q q 1 0 0 1 144.4491 223.0479 cm 0 0 m 2.228 0 l h f Q q 1 0 0 1 144.449 223.0481 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 145.5633 221.9337 cm 0 0 m 0 2.23 l h f Q q 1 0 0 1 145.5632 221.9337 cm 0 0 m 0 0 l 0 2.23 l 0 0 l h S Q q 1 0 0 1 171.7218 223.0479 cm 0 0 m 2.227 0 l h f Q q 1 0 0 1 171.7214 223.0481 cm 0 0 m 2.228 0 l 0 0 l h S Q q 1 0 0 1 172.8351 221.9337 cm 0 0 m 0 2.23 l h f Q q 1 0 0 1 172.8353 221.9337 cm 0 0 m 0 0 l 0 2.23 l 0 0 l h S Q q 1 0 0 1 181.1925 223.0479 cm 0 0 m 2.228 0 l h f Q q 1 0 0 1 181.1929 223.0481 cm 0 0 m 2.228 0 l 0 0 l h S Q q 1 0 0 1 182.3067 221.9337 cm 0 0 m 0 2.23 l h f Q q 1 0 0 1 182.3067 221.9337 cm 0 0 m 0 0 l 0 2.23 l 0 0 l h S Q q 1 0 0 1 194.0067 223.0479 cm 0 0 m 2.228 0 l h f Q q 1 0 0 1 194.007 223.0481 cm 0 0 m 2.228 0 l 0 0 l h S Q q 1 0 0 1 195.1218 221.9337 cm 0 0 m 0 2.23 l h f Q q 1 0 0 1 195.1214 221.9337 cm 0 0 m 0 0 l 0 2.23 l 0 0 l h S Q q 1 0 0 1 204.5925 223.0479 cm 0 0 m 2.228 0 l h f Q q 1 0 0 1 204.5928 223.0481 cm 0 0 m 2.228 0 l 0 0 l h S Q q 1 0 0 1 205.7067 221.9337 cm 0 0 m 0 2.23 l h f Q q 1 0 0 1 205.7067 221.9337 cm 0 0 m 0 0 l 0 2.23 l 0 0 l h S Q q 1 0 0 1 209.0502 223.0479 cm 0 0 m 2.228 0 l h f Q q 1 0 0 1 209.0499 223.0481 cm 0 0 m 2.228 0 l 0 0 l h S Q q 1 0 0 1 210.1635 221.9337 cm 0 0 m 0 2.23 l h f Q q 1 0 0 1 210.1638 221.9337 cm 0 0 m 0 0 l 0 2.23 l 0 0 l h S Q q 1 0 0 1 209.0502 223.0479 cm 0 0 m 2.228 0 l h f Q q 1 0 0 1 209.0499 223.0481 cm 0 0 m 2.228 0 l 0 0 l h S Q q 1 0 0 1 210.1635 221.9337 cm 0 0 m 0 2.23 l h f Q q 1 0 0 1 210.1638 221.9337 cm 0 0 m 0 0 l 0 2.23 l 0 0 l h S Q q 1 0 0 1 234.6507 223.0479 cm 0 0 m 2.228 0 l h f Q q 1 0 0 1 234.6504 223.0481 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 235.7649 221.9337 cm 0 0 m 0 2.23 l h f Q q 1 0 0 1 235.7648 221.9337 cm 0 0 m 0 0 l 0 2.23 l 0 0 l h S Q q 42.52 133.396 221.102 163.773 re W n 0.557 w q 1 0 0 1 68.1482 160.9372 cm 0 0 m 0 -0.464 0.372 -0.836 0.836 -0.836 c 1.3 -0.836 1.672 -0.464 1.672 0 c 1.672 0.464 1.3 0.836 0.836 0.836 c 0.372 0.836 0 0.464 0 0 c h S Q q 1 0 0 1 71.4911 162.6091 cm 0 0 m 0 -0.464 0.372 -0.836 0.836 -0.836 c 1.3 -0.836 1.672 -0.464 1.672 0 c 1.672 0.464 1.3 0.836 0.836 0.836 c 0.372 0.836 0 0.464 0 0 c h S Q q 1 0 0 1 71.4911 164.8385 cm 0 0 m 0 -0.464 0.372 -0.836 0.836 -0.836 c 1.3 -0.836 1.672 -0.464 1.672 0 c 1.672 0.464 1.3 0.836 0.836 0.836 c 0.372 0.836 0 0.464 0 0 c h S Q q 1 0 0 1 73.7197 167.0676 cm 0 0 m 0 -0.464 0.372 -0.836 0.836 -0.836 c 1.3 -0.836 1.672 -0.464 1.672 0 c 1.672 0.464 1.3 0.836 0.836 0.836 c 0.372 0.836 0 0.464 0 0 c h S Q q 1 0 0 1 74.8342 169.2966 cm 0 0 m 0 -0.464 0.372 -0.836 0.836 -0.836 c 1.3 -0.836 1.672 -0.464 1.672 0 c 1.672 0.464 1.3 0.836 0.836 0.836 c 0.372 0.836 0 0.464 0 0 c h S Q q 1 0 0 1 75.3911 170.9685 cm 0 0 m 0 -0.464 0.372 -0.836 0.836 -0.836 c 1.3 -0.836 1.672 -0.464 1.672 0 c 1.672 0.464 1.3 0.836 0.836 0.836 c 0.372 0.836 0 0.464 0 0 c h S Q q 1 0 0 1 77.6196 173.1979 cm 0 0 m 0 -0.464 0.372 -0.836 0.836 -0.836 c 1.3 -0.836 1.672 -0.464 1.672 0 c 1.672 0.464 1.3 0.836 0.836 0.836 c 0.372 0.836 0 0.464 0 0 c h S Q q 1 0 0 1 78.1768 175.427 cm 0 0 m 0 -0.464 0.366 -0.836 0.822 -0.836 c 1.278 -0.836 1.644 -0.464 1.644 0 c 1.644 0.464 1.278 0.836 0.822 0.836 c 0.366 0.836 0 0.464 0 0 c h S Q q 1 0 0 1 78.7341 177.6564 cm 0 0 m 0 -0.464 0.365 -0.836 0.822 -0.836 c 1.278 -0.836 1.644 -0.464 1.644 0 c 1.644 0.464 1.278 0.836 0.822 0.836 c 0.365 0.836 0 0.464 0 0 c h S Q q 1 0 0 1 79.8204 179.3283 cm 0 0 m 0 -0.464 0.372 -0.836 0.836 -0.836 c 1.3 -0.836 1.672 -0.464 1.672 0 c 1.672 0.464 1.3 0.836 0.836 0.836 c 0.372 0.836 0 0.464 0 0 c h S Q q 1 0 0 1 84.8347 181.5573 cm 0 0 m 0 -0.464 0.372 -0.836 0.836 -0.836 c 1.3 -0.836 1.672 -0.464 1.672 0 c 1.672 0.464 1.3 0.836 0.836 0.836 c 0.372 0.836 0 0.464 0 0 c h S Q q 1 0 0 1 84.8347 183.7865 cm 0 0 m 0 -0.464 0.372 -0.836 0.836 -0.836 c 1.3 -0.836 1.672 -0.464 1.672 0 c 1.672 0.464 1.3 0.836 0.836 0.836 c 0.372 0.836 0 0.464 0 0 c h S Q q 1 0 0 1 87.0633 186.0158 cm 0 0 m 0 -0.464 0.372 -0.836 0.836 -0.836 c 1.3 -0.836 1.672 -0.464 1.672 0 c 1.672 0.464 1.3 0.836 0.836 0.836 c 0.372 0.836 0 0.464 0 0 c h S Q q 1 0 0 1 89.2918 187.6877 cm 0 0 m 0 -0.464 0.372 -0.836 0.836 -0.836 c 1.3 -0.836 1.672 -0.464 1.672 0 c 1.672 0.464 1.3 0.836 0.836 0.836 c 0.372 0.836 0 0.464 0 0 c h S Q q 1 0 0 1 89.2918 189.9168 cm 0 0 m 0 -0.464 0.372 -0.836 0.836 -0.836 c 1.3 -0.836 1.672 -0.464 1.672 0 c 1.672 0.464 1.3 0.836 0.836 0.836 c 0.372 0.836 0 0.464 0 0 c h S Q q 1 0 0 1 91.5204 192.1462 cm 0 0 m 0 -0.464 0.372 -0.836 0.836 -0.836 c 1.3 -0.836 1.672 -0.464 1.672 0 c 1.672 0.464 1.3 0.836 0.836 0.836 c 0.372 0.836 0 0.464 0 0 c h S Q q 1 0 0 1 93.749 194.3753 cm 0 0 m 0 -0.464 0.372 -0.836 0.836 -0.836 c 1.3 -0.836 1.672 -0.464 1.672 0 c 1.672 0.464 1.3 0.836 0.836 0.836 c 0.372 0.836 0 0.464 0 0 c h S Q q 1 0 0 1 95.4206 196.0472 cm 0 0 m 0 -0.464 0.372 -0.836 0.836 -0.836 c 1.3 -0.836 1.672 -0.464 1.672 0 c 1.672 0.464 1.3 0.836 0.836 0.836 c 0.372 0.836 0 0.464 0 0 c h S Q q 1 0 0 1 99.3205 198.2766 cm 0 0 m 0 -0.465 0.372 -0.836 0.836 -0.836 c 1.3 -0.836 1.672 -0.465 1.672 0 c 1.672 0.464 1.3 0.836 0.836 0.836 c 0.372 0.836 0 0.464 0 0 c h S Q q 1 0 0 1 108.7919 200.5056 cm 0 0 m 0 -0.464 0.372 -0.836 0.836 -0.836 c 1.3 -0.836 1.672 -0.464 1.672 0 c 1.672 0.464 1.3 0.836 0.836 0.836 c 0.372 0.836 0 0.464 0 0 c h S Q q 1 0 0 1 116.592 202.7348 cm 0 0 m 0 -0.464 0.372 -0.836 0.836 -0.836 c 1.3 -0.836 1.672 -0.464 1.672 0 c 1.672 0.464 1.3 0.836 0.836 0.836 c 0.372 0.836 0 0.464 0 0 c h S Q q 1 0 0 1 121.6063 204.9641 cm 0 0 m 0 -0.464 0.372 -0.836 0.836 -0.836 c 1.3 -0.836 1.672 -0.464 1.672 0 c 1.672 0.464 1.3 0.836 0.836 0.836 c 0.372 0.836 0 0.464 0 0 c h S Q q 1 0 0 1 124.3918 207.1933 cm 0 0 m 0 -0.464 0.372 -0.836 0.836 -0.836 c 1.3 -0.836 1.672 -0.464 1.672 0 c 1.672 0.464 1.3 0.836 0.836 0.836 c 0.372 0.836 0 0.464 0 0 c h S Q q 1 0 0 1 124.949 209.4223 cm 0 0 m 0 -0.464 0.372 -0.836 0.836 -0.836 c 1.3 -0.836 1.672 -0.464 1.672 0 c 1.672 0.464 1.3 0.836 0.836 0.836 c 0.372 0.836 0 0.464 0 0 c h S Q q 1 0 0 1 129.4061 212.7661 cm 0 0 m 0 -0.464 0.372 -0.836 0.836 -0.836 c 1.3 -0.836 1.672 -0.464 1.672 0 c 1.672 0.465 1.3 0.836 0.836 0.836 c 0.372 0.836 0 0.465 0 0 c h S Q q 1 0 0 1 129.9633 215.5388 cm 0 0 m 0 -0.457 0.372 -0.822 0.836 -0.822 c 1.3 -0.822 1.672 -0.457 1.672 0 c 1.672 0.457 1.3 0.822 0.836 0.822 c 0.372 0.822 0 0.457 0 0 c h S Q q 1 0 0 1 133.8632 218.869 cm 0 0 m 0 -0.465 0.372 -0.836 0.836 -0.836 c 1.3 -0.836 1.672 -0.465 1.672 0 c 1.672 0.464 1.3 0.836 0.836 0.836 c 0.372 0.836 0 0.464 0 0 c h S Q q 1 0 0 1 136.649 222.7695 cm 0 0 m 0 -0.464 0.372 -0.836 0.836 -0.836 c 1.3 -0.836 1.672 -0.464 1.672 0 c 1.672 0.465 1.3 0.836 0.836 0.836 c 0.372 0.836 0 0.465 0 0 c h S Q Q 0 0.994 1 0 K 0.557 w q 1 0 0 1 68.984 158.8474 cm 0 0 m 2.312 0 l S Q q 1 0 0 1 71.2961 158.8474 cm 0 0 m 0.195 0.139 l S Q q 1 0 0 1 71.4911 161.2158 cm 0 0 m -0.195 1.031 l S Q q 1 0 0 1 71.2961 162.247 cm 0 0 m 0.808 0 l S Q q 1 0 0 1 72.1041 162.247 cm 0 0 m -0.056 0.641 l S Q q 1 0 0 1 72.0484 165.1171 cm 0 0 m 0.056 0.529 l S Q q 1 0 0 1 72.1041 165.6465 cm 0 0 m 0.975 0 l S Q q 1 0 0 1 73.079 165.6465 cm 0 0 m 0.084 0.585 l S Q q 1 0 0 1 73.1625 168.4608 cm 0 0 m -0.084 0.557 l S Q q 1 0 0 1 73.079 169.018 cm 0 0 m 0.697 0 l S Q q 1 0 0 1 73.7755 169.018 cm 0 0 m -0.056 1.114 l S Q q 1 0 0 1 73.7197 172.3618 cm 0 0 m 2.229 0 l S Q q 1 0 0 1 77.6196 172.9193 cm 0 0 m 0 2.229 l S Q q 1 0 0 1 78.1768 176.8203 cm 0 0 m -0.084 2.397 l S Q q 1 0 0 1 78.0933 179.2167 cm 0 0 m 0.084 -0.167 l S Q q 1 0 0 1 79.2913 180.1641 cm 0 0 m 0.111 2.424 l S Q q 1 0 0 1 79.4025 182.5882 cm 0 0 m -0.111 -0.195 l S Q q 1 0 0 1 81.4918 182.3934 cm 0 0 m 1.087 0.195 l S Q q 1 0 0 1 82.5784 182.5882 cm 0 0 m 0.028 0.919 l S Q q 1 0 0 1 82.6062 185.7372 cm 0 0 m -0.028 0.251 l S Q q 1 0 0 1 82.5784 185.9878 cm 0 0 m 1.699 0.306 l S Q q 1 0 0 1 85.9491 186.8517 cm 0 0 m 0 2.229 l S Q q 1 0 0 1 87.6205 189.6382 cm 0 0 m 0 2.229 l S Q q 1 0 0 1 88.7346 192.982 cm 0 0 m 2.062 -0.223 l S Q q 1 0 0 1 90.7961 192.7592 cm 0 0 m 0.167 0.223 l S Q q 1 0 0 1 90.9632 195.2114 cm 0 0 m -0.167 0.947 l S Q q 1 0 0 1 90.7961 196.1587 cm 0 0 m 0.641 0 l S Q q 1 0 0 1 91.4369 196.1587 cm 0 0 m 0.084 0.724 l S Q q 1 0 0 1 91.5204 199.1124 cm 0 0 m -0.084 0.446 l S Q q 1 0 0 1 91.4369 199.5583 cm 0 0 m 0.418 0 l S Q q 1 0 0 1 91.8548 199.5583 cm 0 0 m 0.223 1.226 l S Q q 1 0 0 1 92.0776 203.0134 cm 0 0 m 1.839 -0.084 l S Q q 1 0 0 1 93.9163 202.9298 cm 0 0 m -0.167 0.641 l S Q q 1 0 0 1 93.749 205.8 cm 0 0 m 0.167 0.529 l S Q q 1 0 0 1 93.9163 206.3294 cm 0 0 m 1.504 0.028 l S Q q 1 0 0 1 97.6492 206.3572 cm 0 0 m 0 2.229 l S Q q 1 0 0 1 98.7633 209.7012 cm 0 0 m 0 2.229 l S Q q 1 0 0 1 99.3205 213.6022 cm 0 0 m 0 2.202 l S Q q 1 0 0 1 100.9918 216.3605 cm 0 0 m 2.229 0 l S Q q 1 0 0 1 104.3348 217.476 cm 0 0 m 0.195 2.424 l S Q q 1 0 0 1 104.5299 219.8996 cm 0 0 m -0.195 -0.195 l S Q q 1 0 0 1 106.5633 219.7048 cm 0 0 m 1.839 0.195 l S Q q 1 0 0 1 108.402 219.8996 cm 0 0 m -0.167 0.362 l S Q q 1 0 0 1 108.2347 222.4908 cm 0 0 m 0.167 0.809 l S Q q 1 0 0 1 108.402 223.2994 cm 0 0 m 1.504 -0.251 l S Q q 1 0 0 1 112.1349 223.0481 cm 0 0 m 2.368 0.251 l S Q q 1 0 0 1 114.5027 223.2994 cm 0 0 m -0.139 -0.251 l S Q q 1 0 0 1 114.3634 225.278 cm 0 0 m 0.139 1.393 l S Q q 1 0 0 1 114.5027 226.671 cm 0 0 m 0.446 0 l S Q q 1 0 0 1 114.9484 226.671 cm 0 0 m -0.028 0.279 l S Q q 1 0 0 1 114.9204 229.1784 cm 0 0 m 0.028 0.893 l S Q q 1 0 0 1 114.9484 230.0708 cm 0 0 m 0.864 0 l S Q q 1 0 0 1 115.812 230.0708 cm 0 0 m 0.223 0.223 l S Q q 1 0 0 1 116.0348 232.5228 cm 0 0 m -0.223 0.947 l S Q q 1 0 0 1 115.812 233.4696 cm 0 0 m 1.142 0 l S Q q 1 0 0 1 116.9541 233.4696 cm 0 0 m 0.195 0.168 l S Q q 1 0 0 1 117.1489 235.866 cm 0 0 m -0.195 1.004 l S Q q 1 0 0 1 116.9541 236.8694 cm 0 0 m 1.309 0.112 l S Q q 1 0 0 1 120.4919 236.9815 cm 0 0 m 0 2.229 l S Q q 1 0 0 1 121.6063 240.3247 cm 0 0 m 0 2.229 l S Q q 1 0 0 1 122.7204 243.6691 cm 0 0 m 2.229 0 l S Q q 1 0 0 1 127.1775 243.6691 cm 0 0 m 1.978 -0.028 l S Q q 1 0 0 1 129.1555 243.6407 cm 0 0 m 0.251 0.028 l S Q q 1 0 0 1 129.4061 245.8979 cm 0 0 m -0.251 1.143 l S Q q 1 0 0 1 129.1555 247.0406 cm 0 0 m 1.365 -0.028 l S Q q 1 0 0 1 132.749 247.0123 cm 0 0 m 0 2.229 l S Q q 1 0 0 1 133.8632 250.3566 cm 0 0 m 2.229 0 l S Q q 1 0 0 1 138.3206 250.3566 cm 0 0 m 2.229 0 l S Q q 1 0 0 1 142.7777 250.3566 cm 0 0 m 2.229 0 l S Q q 1 0 0 1 147.2348 250.3566 cm 0 0 m 2.229 0 l S Q q 1 0 0 1 151.6919 250.3566 cm 0 0 m 2.061 0.056 l S Q q 1 0 0 1 153.7532 250.4121 cm 0 0 m 0.139 -0.056 l S Q q 1 0 0 1 153.8925 252.5854 cm 0 0 m -0.139 2.09 l S Q q 1 0 0 1 153.7532 254.6749 cm 0 0 m 0.139 0.139 l S Q q 1 0 0 1 154.4497 256.487 cm 0 0 m -0.083 2.424 l S Q q 1 0 0 1 154.3664 258.9106 cm 0 0 m 0.083 -0.195 l S Q q 1 0 0 1 156.6785 258.7158 cm 0 0 m 2.228 0 l S Q q 1 0 0 1 161.1356 258.7158 cm 0 0 m 2.228 0 l S Q q 1 0 0 1 165.5927 258.7158 cm 0 0 m 2.228 0 l S Q q 1 0 0 1 170.0498 258.7158 cm 0 0 m 2.228 0 l S Q q 1 0 0 1 174.5069 258.7158 cm 0 0 m 2.229 0 l S Q q 1 0 0 1 178.964 258.7158 cm 0 0 m 2.229 0 l S Q q 1 0 0 1 183.4211 258.7158 cm 0 0 m 2.229 0 l S Q q 1 0 0 1 187.8782 258.7158 cm 0 0 m 2.229 0 l S Q q 1 0 0 1 192.3353 258.7158 cm 0 0 m 2.006 0.195 l S Q q 1 0 0 1 194.341 258.9106 cm 0 0 m 0.223 -0.195 l S Q q 1 0 0 1 196.7925 258.7158 cm 0 0 m 2.229 0 l S Q q 1 0 0 1 201.2496 258.7158 cm 0 0 m 2.229 0 l S Q q 1 0 0 1 205.7067 258.7158 cm 0 0 m 2.229 0 l S Q q 1 0 0 1 210.1638 258.7158 cm 0 0 m 2.229 0 l S Q q 1 0 0 1 214.6214 258.7158 cm 0 0 m 2.228 0 l S Q q 1 0 0 1 219.0786 258.7158 cm 0 0 m 2.228 0 l S Q q 1 0 0 1 223.5357 258.7158 cm 0 0 m 2.228 0 l S Q q 1 0 0 1 227.965 258.7158 cm 0 0 m 2.228 0 l S Q 0 0.994 1 0 k q 1 0 0 1 151.6923 250.3566 cm 0 0 m 2.2 0 l h f Q 0.279 w q 1 0 0 1 151.6919 250.3566 cm 0 0 m 2.2 0 l 0 0 l h S Q q 1 0 0 1 152.8065 249.2415 cm 0 0 m 0 2.229 l h f Q q 1 0 0 1 152.8063 249.2411 cm 0 0 m 0 0 l 0 2.23 l 0 0 l h S Q q 1 0 0 1 193.4496 258.7158 cm 0 0 m 2.229 0 l h f Q q 1 0 0 1 193.4498 258.7158 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 194.5638 257.6016 cm 0 0 m 0 2.228 l h f Q q 1 0 0 1 194.5642 257.6014 cm 0 0 m 0 0 l 0 2.229 l 0 0 l h S Q q 1 0 0 1 230.7501 258.7158 cm 0 0 m 2.228 0 l h f Q q 1 0 0 1 230.7505 258.7158 cm 0 0 m 2.228 0 l 0 0 l h S Q q 1 0 0 1 231.8652 257.6016 cm 0 0 m 0 2.228 l h f Q q 1 0 0 1 231.8649 257.6014 cm 0 0 m 0 0 l 0 2.229 l 0 0 l h S Q q 42.52 133.396 221.102 163.773 re W n 0.557 w q 1 0 0 1 70.3767 162.0519 cm 0 0 m 0 -0.464 0.372 -0.836 0.836 -0.836 c 1.3 -0.836 1.672 -0.464 1.672 0 c 1.672 0.464 1.3 0.836 0.836 0.836 c 0.372 0.836 0 0.464 0 0 c h S Q q 1 0 0 1 70.9339 165.3957 cm 0 0 m 0 -0.464 0.372 -0.836 0.836 -0.836 c 1.3 -0.836 1.672 -0.464 1.672 0 c 1.672 0.464 1.3 0.836 0.836 0.836 c 0.372 0.836 0 0.464 0 0 c h S Q q 1 0 0 1 72.0484 168.7394 cm 0 0 m 0 -0.464 0.372 -0.836 0.836 -0.836 c 1.3 -0.836 1.672 -0.464 1.672 0 c 1.672 0.464 1.3 0.836 0.836 0.836 c 0.372 0.836 0 0.464 0 0 c h S Q q 1 0 0 1 72.6056 172.0832 cm 0 0 m 0 -0.464 0.372 -0.836 0.836 -0.836 c 1.3 -0.836 1.672 -0.464 1.672 0 c 1.672 0.464 1.3 0.836 0.836 0.836 c 0.372 0.836 0 0.464 0 0 c h S Q q 1 0 0 1 76.5055 175.427 cm 0 0 m 0 -0.464 0.372 -0.836 0.836 -0.836 c 1.3 -0.836 1.672 -0.464 1.672 0 c 1.672 0.464 1.3 0.836 0.836 0.836 c 0.372 0.836 0 0.464 0 0 c h S Q q 1 0 0 1 77.0627 178.7708 cm 0 0 m 0 -0.464 0.372 -0.836 0.836 -0.836 c 1.3 -0.836 1.672 -0.464 1.672 0 c 1.672 0.464 1.3 0.836 0.836 0.836 c 0.372 0.836 0 0.464 0 0 c h S Q q 1 0 0 1 78.1768 182.1146 cm 0 0 m 0 -0.464 0.366 -0.836 0.822 -0.836 c 1.278 -0.836 1.644 -0.464 1.644 0 c 1.644 0.464 1.278 0.836 0.822 0.836 c 0.366 0.836 0 0.464 0 0 c h S Q q 1 0 0 1 81.4918 186.0158 cm 0 0 m 0 -0.464 0.372 -0.836 0.836 -0.836 c 1.3 -0.836 1.672 -0.464 1.672 0 c 1.672 0.464 1.3 0.836 0.836 0.836 c 0.372 0.836 0 0.464 0 0 c h S Q q 1 0 0 1 84.8347 189.3596 cm 0 0 m 0 -0.464 0.372 -0.836 0.836 -0.836 c 1.3 -0.836 1.672 -0.464 1.672 0 c 1.672 0.464 1.3 0.836 0.836 0.836 c 0.372 0.836 0 0.464 0 0 c h S Q q 1 0 0 1 86.5061 192.7034 cm 0 0 m 0 -0.464 0.372 -0.836 0.836 -0.836 c 1.3 -0.836 1.672 -0.464 1.672 0 c 1.672 0.464 1.3 0.836 0.836 0.836 c 0.372 0.836 0 0.464 0 0 c h S Q q 1 0 0 1 89.849 196.0472 cm 0 0 m 0 -0.464 0.372 -0.836 0.836 -0.836 c 1.3 -0.836 1.672 -0.464 1.672 0 c 1.672 0.464 1.3 0.836 0.836 0.836 c 0.372 0.836 0 0.464 0 0 c h S Q q 1 0 0 1 90.4063 199.391 cm 0 0 m 0 -0.464 0.372 -0.836 0.836 -0.836 c 1.3 -0.836 1.672 -0.464 1.672 0 c 1.672 0.464 1.3 0.836 0.836 0.836 c 0.372 0.836 0 0.464 0 0 c h S Q q 1 0 0 1 90.9632 202.7348 cm 0 0 m 0 -0.464 0.372 -0.836 0.836 -0.836 c 1.3 -0.836 1.672 -0.464 1.672 0 c 1.672 0.464 1.3 0.836 0.836 0.836 c 0.372 0.836 0 0.464 0 0 c h S Q q 1 0 0 1 92.6348 206.0786 cm 0 0 m 0 -0.464 0.372 -0.836 0.836 -0.836 c 1.3 -0.836 1.672 -0.464 1.672 0 c 1.672 0.464 1.3 0.836 0.836 0.836 c 0.372 0.836 0 0.464 0 0 c h S Q q 1 0 0 1 96.5347 209.4223 cm 0 0 m 0 -0.464 0.372 -0.836 0.836 -0.836 c 1.3 -0.836 1.672 -0.464 1.672 0 c 1.672 0.464 1.3 0.836 0.836 0.836 c 0.372 0.836 0 0.464 0 0 c h S Q q 1 0 0 1 97.6492 212.7661 cm 0 0 m 0 -0.464 0.372 -0.836 0.836 -0.836 c 1.3 -0.836 1.672 -0.464 1.672 0 c 1.672 0.465 1.3 0.836 0.836 0.836 c 0.372 0.836 0 0.465 0 0 c h S Q q 1 0 0 1 98.2061 216.096 cm 0 0 m 0 -0.456 0.372 -0.822 0.836 -0.822 c 1.3 -0.822 1.672 -0.456 1.672 0 c 1.672 0.457 1.3 0.822 0.836 0.822 c 0.372 0.822 0 0.457 0 0 c h S Q q 1 0 0 1 103.2204 219.4262 cm 0 0 m 0 -0.465 0.372 -0.836 0.836 -0.836 c 1.3 -0.836 1.672 -0.465 1.672 0 c 1.672 0.465 1.3 0.836 0.836 0.836 c 0.372 0.836 0 0.465 0 0 c h S Q q 1 0 0 1 107.1205 222.7695 cm 0 0 m 0 -0.464 0.372 -0.836 0.836 -0.836 c 1.3 -0.836 1.672 -0.464 1.672 0 c 1.672 0.465 1.3 0.836 0.836 0.836 c 0.372 0.836 0 0.465 0 0 c h S Q q 1 0 0 1 113.249 226.671 cm 0 0 m 0 -0.465 0.372 -0.836 0.836 -0.836 c 1.3 -0.836 1.672 -0.465 1.672 0 c 1.672 0.465 1.3 0.836 0.836 0.836 c 0.372 0.836 0 0.465 0 0 c h S Q q 1 0 0 1 113.8062 230.0142 cm 0 0 m 0 -0.464 0.372 -0.836 0.836 -0.836 c 1.3 -0.836 1.672 -0.464 1.672 0 c 1.672 0.465 1.3 0.837 0.836 0.837 c 0.372 0.837 0 0.465 0 0 c h S Q q 1 0 0 1 114.9204 233.3586 cm 0 0 m 0 -0.465 0.372 -0.836 0.836 -0.836 c 1.3 -0.836 1.672 -0.465 1.672 0 c 1.672 0.465 1.3 0.836 0.836 0.836 c 0.372 0.836 0 0.465 0 0 c h S Q q 1 0 0 1 116.0348 236.7029 cm 0 0 m 0 -0.465 0.372 -0.837 0.836 -0.837 c 1.3 -0.837 1.672 -0.465 1.672 0 c 1.672 0.464 1.3 0.836 0.836 0.836 c 0.372 0.836 0 0.464 0 0 c h S Q q 1 0 0 1 119.3778 240.0461 cm 0 0 m 0 -0.465 0.372 -0.836 0.836 -0.836 c 1.3 -0.836 1.672 -0.465 1.672 0 c 1.672 0.465 1.3 0.836 0.836 0.836 c 0.372 0.836 0 0.465 0 0 c h S Q q 1 0 0 1 120.4919 243.3905 cm 0 0 m 0 -0.465 0.372 -0.837 0.836 -0.837 c 1.3 -0.837 1.672 -0.465 1.672 0 c 1.672 0.464 1.3 0.836 0.836 0.836 c 0.372 0.836 0 0.464 0 0 c h S Q q 1 0 0 1 128.292 246.7337 cm 0 0 m 0 -0.465 0.372 -0.836 0.836 -0.836 c 1.3 -0.836 1.672 -0.465 1.672 0 c 1.672 0.465 1.3 0.836 0.836 0.836 c 0.372 0.836 0 0.465 0 0 c h S Q q 1 0 0 1 131.6346 250.078 cm 0 0 m 0 -0.465 0.372 -0.837 0.836 -0.837 c 1.3 -0.837 1.672 -0.465 1.672 0 c 1.672 0.464 1.3 0.836 0.836 0.836 c 0.372 0.836 0 0.464 0 0 c h S Q q 1 0 0 1 152.8063 254.5356 cm 0 0 m 0 -0.464 0.365 -0.836 0.822 -0.836 c 1.278 -0.836 1.643 -0.464 1.643 0 c 1.643 0.465 1.278 0.836 0.822 0.836 c 0.365 0.836 0 0.465 0 0 c h S Q q 1 0 0 1 153.3353 258.4372 cm 0 0 m 0 -0.465 0.372 -0.836 0.836 -0.836 c 1.301 -0.836 1.672 -0.465 1.672 0 c 1.672 0.465 1.301 0.836 0.836 0.836 c 0.372 0.836 0 0.465 0 0 c h S Q Q 0 0 0 1 K 0.557 w /GS1 gs q 1 0 0 1 64.2483 278.2213 cm 0 0 m 194.331 0 l S Q q 1 0 0 1 68.984 277.1341 cm 0 0 m 0 1.087 l S Q q 1 0 0 1 87.9268 277.1341 cm 0 0 m 0 1.087 l S Q q 1 0 0 1 106.8977 277.1341 cm 0 0 m 0 1.087 l S Q q 1 0 0 1 125.8683 277.1341 cm 0 0 m 0 1.087 l S Q q 1 0 0 1 144.8112 277.1341 cm 0 0 m 0 1.087 l S Q q 1 0 0 1 163.7818 277.1341 cm 0 0 m 0 1.087 l S Q q 1 0 0 1 182.7524 277.1341 cm 0 0 m 0 1.087 l S Q q 1 0 0 1 201.6952 277.1341 cm 0 0 m 0 1.087 l S Q q 1 0 0 1 220.6664 277.1341 cm 0 0 m 0 1.087 l S Q q 1 0 0 1 239.637 277.1341 cm 0 0 m 0 1.087 l S Q q 1 0 0 1 258.5798 277.1341 cm 0 0 m 0 1.087 l S Q BT 0 0 0 1 k /TT2 1 Tf 4.495 0 0 -4.6535 67.8704 284.6281 Tm (0)Tj 3.966 0 Td (1)Tj 0.496 0 Td (0)Tj 3.724 0 Td (2)Tj 0.496 0 Td (0)Tj 3.724 0 Td (3)Tj 0.496 0 Td (0)Tj 3.719 0 Td (4)Tj 0.496 0 Td (0)Tj 3.724 0 Td (5)Tj 0.496 0 Td (0)Tj 3.723 0 Td (6)Tj 0.496 0 Td (0)Tj 3.719 0 Td (7)Tj 0.496 0 Td (0)Tj 3.724 0 Td (8)Tj 0.496 0 Td (0)Tj 3.724 0 Td (9)Tj 0.496 0 Td (0)Tj 3.47 0 Td (1)Tj 0.496 0 Td (0)Tj 0.496 0 Td (0)Tj /C2_2 1 Tf -30.231 -1.857 Td <023C>Tj 0.62 0 Td <026A>Tj 0.496 0 Td <025F>Tj 0.496 0 Td <0266>Tj 0.744 0 Td <0279>Tj /TT2 1 Tf 0.496 0 Td ( )Tj /C2_2 1 Tf 0.249 0 Td <0268>Tj 0.496 0 Td <026C>Tj /TT2 1 Tf 0.495 0 Td ( )Tj /C2_2 1 Tf 0.249 0 Td <0269>Tj 0.497 0 Td <026A>Tj 0.496 0 Td <0268>Tj 0.496 0 Td <025C>Tj 0.496 0 Td <025F>Tj 0.496 0 Td <025E>Tj 0.62 0 Td <025F>Tj 0.496 0 Td <0267>Tj 0.49 0 Td <0267>Tj 0.496 0 Td <0268>Tj 0.496 0 Td <0263>Tj /TT2 1 Tf 0.497 0 Td ( )Tj /C2_2 1 Tf 0.249 0 Td <0268>Tj 0.496 0 Td <0269>Tj 0.496 0 Td <025F>Tj 0.496 0 Td <026A>Tj 0.496 0 Td <025A>Tj 0.496 0 Td <0270>Tj 0.619 0 Td <0262>Tj 0.497 0 Td <0262>Tj /TT2 1 Tf 0.497 0 Td (,)Tj 0.249 0 Td ( )Tj /C2_2 1 Tf 0.249 0 Td <0266>Tj 0.743 0 Td <025F>Tj 0.496 0 Td <026B>Tj /TT2 1 Tf 0.496 0 Td (.)Tj ET q 1 0 0 1 64.2483 153.4138 cm 0 0 m 194.331 0 l S Q q 1 0 0 1 68.984 154.5282 cm 0 0 m 0 -1.114 l S Q q 1 0 0 1 87.9268 154.5282 cm 0 0 m 0 -1.114 l S Q q 1 0 0 1 106.8977 154.5282 cm 0 0 m 0 -1.114 l S Q q 1 0 0 1 125.8683 154.5282 cm 0 0 m 0 -1.114 l S Q q 1 0 0 1 144.8112 154.5282 cm 0 0 m 0 -1.114 l S Q q 1 0 0 1 163.7818 154.5282 cm 0 0 m 0 -1.114 l S Q q 1 0 0 1 182.7524 154.5282 cm 0 0 m 0 -1.114 l S Q q 1 0 0 1 201.6952 154.5282 cm 0 0 m 0 -1.114 l S Q q 1 0 0 1 220.6664 154.5282 cm 0 0 m 0 -1.114 l S Q q 1 0 0 1 239.637 154.5282 cm 0 0 m 0 -1.114 l S Q q 1 0 0 1 258.5798 154.5282 cm 0 0 m 0 -1.114 l S Q q 1 0 0 1 64.2483 278.2213 cm 0 0 m 0 -124.808 l S Q q 1 0 0 1 65.3347 278.2496 cm 0 0 m -1.087 0 l S Q q 1 0 0 1 65.3347 267.3819 cm 0 0 m -1.087 0 l S Q q 1 0 0 1 65.3347 256.5425 cm 0 0 m -1.087 0 l S Q q 1 0 0 1 65.3347 245.6748 cm 0 0 m -1.087 0 l S Q q 1 0 0 1 65.3347 234.8354 cm 0 0 m -1.087 0 l S Q q 1 0 0 1 65.3347 223.9677 cm 0 0 m -1.087 0 l S Q q 1 0 0 1 65.3347 213.1285 cm 0 0 m -1.087 0 l S Q q 1 0 0 1 65.3347 202.2611 cm 0 0 m -1.087 0 l S Q q 1 0 0 1 65.3347 191.4217 cm 0 0 m -1.087 0 l S Q q 1 0 0 1 65.3347 180.5543 cm 0 0 m -1.087 0 l S Q q 1 0 0 1 65.3347 169.7148 cm 0 0 m -1.087 0 l S Q q 1 0 0 1 65.3347 158.8474 cm 0 0 m -1.087 0 l S Q BT /TT2 1 Tf 4.495 0 0 -4.6535 54.7761 279.6394 Tm (-)Tj 0.371 0 Td (0)Tj 0.496 0 Td (,)Tj 0.249 0 Td (1)Tj -0.744 2.335 Td (0)Tj 0.496 0 Td (,)Tj 0.249 0 Td (0)Tj -0.745 2.329 Td (0)Tj 0.496 0 Td (,)Tj 0.249 0 Td (1)Tj -0.745 2.335 Td (0)Tj 0.496 0 Td (,)Tj 0.249 0 Td (2)Tj -0.745 2.329 Td (0)Tj 0.496 0 Td (,)Tj 0.249 0 Td (3)Tj -0.745 2.336 Td (0)Tj 0.496 0 Td (,)Tj 0.249 0 Td (4)Tj -0.745 2.329 Td (0)Tj 0.496 0 Td (,)Tj 0.249 0 Td (5)Tj -0.745 2.335 Td (0)Tj 0.496 0 Td (,)Tj 0.249 0 Td (6)Tj -0.745 2.329 Td (0)Tj 0.496 0 Td (,)Tj 0.249 0 Td (7)Tj -0.745 2.336 Td (0)Tj 0.496 0 Td (,)Tj 0.249 0 Td (8)Tj -0.745 2.328 Td (0)Tj 0.496 0 Td (,)Tj 0.249 0 Td (9)Tj -0.745 2.337 Td (1)Tj 0.496 0 Td (,)Tj 0.249 0 Td (0)Tj /C2_2 1 Tf 0 -4.6535 -4.6521 0 49.757 249.8199 Tm <0244>Tj 0.598 0 Td <026D>Tj 0.48 0 Td <0266>Tj 0.719 0 Td <026D>Tj 0.48 0 Td <0265>Tj 0.598 0 Td <0279>Tj 0.598 0 Td <026C>Tj 0.479 0 Td <0262>Tj 0.599 0 Td <025C>Tj 0.479 0 Td <0267>Tj 0.598 0 Td <025A>Tj 0.598 0 Td <0279>Tj /TT2 1 Tf 0.598 0 Td ( )Tj /C2_2 1 Tf 0.24 0 Td <025E>Tj 0.598 0 Td <0268>Tj 0.598 0 Td <0265>Tj 0.599 0 Td <0279>Tj /TT2 1 Tf 0.598 0 Td ( )Tj /C2_2 1 Tf 0.24 0 Td <025C>Tj 0.479 0 Td <0275>Tj <0260>Tj 1.437 0 Td <0262>Tj 0.599 0 Td <025C>Tj 0.479 0 Td <0272>Tj 0.838 0 Td <0262>Tj 0.599 0 Td <026F>Tj ET q 1 0 0 1 258.6076 278.2213 cm 0 0 m 0 -124.808 l S Q q 1 0 0 1 257.4932 278.2496 cm 0 0 m 1.087 0 l S Q q 1 0 0 1 257.4932 267.3819 cm 0 0 m 1.114 0 l S Q q 1 0 0 1 257.4932 256.5425 cm 0 0 m 1.114 0 l S Q q 1 0 0 1 257.4932 245.6748 cm 0 0 m 1.114 0 l S Q q 1 0 0 1 257.4932 234.8354 cm 0 0 m 1.114 0 l S Q q 1 0 0 1 257.4932 223.9677 cm 0 0 m 1.114 0 l S Q q 1 0 0 1 257.4932 213.1285 cm 0 0 m 1.114 0 l S Q q 1 0 0 1 257.4932 202.2611 cm 0 0 m 1.114 0 l S Q q 1 0 0 1 257.4932 191.4217 cm 0 0 m 1.114 0 l S Q q 1 0 0 1 257.4932 180.5543 cm 0 0 m 1.114 0 l S Q q 1 0 0 1 257.4932 169.7148 cm 0 0 m 1.114 0 l S Q q 1 0 0 1 257.4932 158.8474 cm 0 0 m 1.114 0 l S Q 0.884 0.769 0 0 K /GS0 gs q 1 0 0 1 164.1164 173.5881 cm 0 0 m 7.438 0 l S Q BT /GS1 gs /TT2 1 Tf 4.495 0 0 -4.6535 172.4729 175.2545 Tm ( )Tj 0.249 0 Td ( )Tj /C2_2 1 Tf 0.249 0 Td <0245>Tj 0.62 0 Td <026D>Tj 0.372 0 Td <0271>Tj 0.496 0 Td <025F>Tj 0.496 0 Td <025C>Tj 0.496 0 Td <025A>Tj 0.496 0 Td <0279>Tj /TT2 1 Tf 0.496 0 Td ( )Tj /C2_2 1 Tf 0.249 0 Td <026C>Tj 0.495 0 Td <025F>Tj 0.496 0 Td <026A>Tj 0.496 0 Td <025A>Tj 0.496 0 Td <0269>Tj 0.496 0 Td <0262>Tj 0.497 0 Td <0279>Tj /TT2 1 Tf 0.497 0 Td ( )Tj /C2_2 1 Tf 0.249 0 Td <0267>Tj 0.49 0 Td <025F>Tj /TT2 1 Tf 0.496 0 Td ( )Tj /C2_2 1 Tf 0.249 0 Td <0269>Tj 0.496 0 Td <026A>Tj 0.496 0 Td <0268>Tj 0.496 0 Td <025C>Tj 0.496 0 Td <0268>Tj 0.496 0 Td <025E>Tj 0.619 0 Td <0262>Tj 0.497 0 Td <0265>Tj 0.619 0 Td <025A>Tj 0.496 0 Td <026B>Tj 0.496 0 Td <0276>Tj ET 0 0.994 1 0 K /GS0 gs q 1 0 0 1 164.1164 179.3003 cm 0 0 m 2.033 0.306 l S Q q 1 0 0 1 168.3782 179.6069 cm 0 0 m 2.229 0 l S Q BT /GS1 gs /TT2 1 Tf 4.495 0 0 -4.6535 172.4729 180.9702 Tm ( )Tj 0.249 0 Td ( )Tj /C2_2 1 Tf 0.249 0 Td <0245>Tj 0.62 0 Td <026D>Tj 0.372 0 Td <0271>Tj 0.496 0 Td <025F>Tj 0.496 0 Td <025C>Tj 0.496 0 Td <025A>Tj 0.496 0 Td <0279>Tj /TT2 1 Tf 0.496 0 Td ( )Tj /C2_2 1 Tf 0.249 0 Td <026C>Tj 0.495 0 Td <025F>Tj 0.496 0 Td <026A>Tj 0.496 0 Td <025A>Tj 0.496 0 Td <0269>Tj 0.496 0 Td <0262>Tj 0.497 0 Td <0279>Tj /TT2 1 Tf 0.497 0 Td ( )Tj 0.249 0 Td ( )Tj /C2_2 1 Tf 0.249 0 Td <0269>Tj 0.49 0 Td <026A>Tj 0.496 0 Td <0268>Tj 0.496 0 Td <025C>Tj 0.496 0 Td <0268>Tj 0.496 0 Td <025E>Tj 0.62 0 Td <0262>Tj 0.497 0 Td <0265>Tj 0.619 0 Td <025A>Tj 0.496 0 Td <026B>Tj 0.496 0 Td <0276>Tj ET EMC BT 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0.018 Tw 9 0 0 9 42.5197 122.5959 Tm (\022\t\217\210\b\002\220 3.)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf ( \216\020\204\025\027\026\031\003\n\t\024\022 \005\n\023\022\021\020\004\ \003\031\024\026\t\024\026\024\025\006\031\t\013\025\003 \032\026)Tj 0 Tw (-)Tj 0.099 Tw 0 -1.2 TD (\013\n\003 \033\032\002\003\n\017 \013\025\001\013\025 \027)Tj /Span<>> BDC ( )Tj EMC [(\016\026\027\025\t\025\003\n\t\024\025 \n\024 \033\032\n\027\031\030\031\ \021\025\002 )0.5(\023\205\006\031\027\n\017 )]TJ 0 Tw 0 -1.2 TD (\024\031\032\026\033\025\025)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf -0.038 Tw 0 -1.2 TD [(F)-16(igure 3.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf [( Sur)-42(viv)16(al rate of patients with metastatic rectal cancer )]TJ 0 Tw T* [(depending on radiation therap)12.2(y)]TJ ET 0 0 0 0 k /GS0 gs 274.961 144.201 221.102 165.49 re f /PlacedPDF /MC3 BDC 0 0.008 0.049 0 k 274.961 144.201 221.102 165.49 re f BT 0 0 0 1 k /GS1 gs /C2_3 1 Tf 4.495 0 0 4.6519 339.0024 301.3383 Tm <0244>Tj 0.62 0 Td <026D>Tj 0.372 0 Td <0266>Tj 0.744 0 Td <026D>Tj 0.372 0 Td <0265>Tj 0.62 0 Td <0279>Tj 0.497 0 Td <026C>Tj 0.495 0 Td <0262>Tj 0.497 0 Td <025C>Tj 0.496 0 Td <0267>Tj 0.496 0 Td <025A>Tj 0.496 0 Td <0279>Tj /TT3 1 Tf 0.497 0 Td ( )Tj /C2_3 1 Tf 0.249 0 Td <025E>Tj 0.62 0 Td <0268>Tj 0.496 0 Td <0265>Tj 0.62 0 Td <0279>Tj /TT3 1 Tf 0.491 0 Td ( )Tj /C2_3 1 Tf 0.249 0 Td <025C>Tj 0.496 0 Td <0275>Tj 0.743 0 Td <0260>Tj 0.62 0 Td <0262>Tj 0.497 0 Td <025C>Tj 0.496 0 Td <0272>Tj 0.744 0 Td <0262>Tj 0.497 0 Td <026F>Tj /TT3 1 Tf 0.372 0 Td ( )Tj 0.249 0 Td (\()Tj /C2_3 1 Tf 0.371 0 Td <0244>Tj 0.619 0 Td <025A>Tj 0.496 0 Td <0269>Tj 0.496 0 Td <0265>Tj 0.619 0 Td <025A>Tj 0.496 0 Td <0267>Tj /TT3 1 Tf 0.496 0 Td (-)Tj /C2_3 1 Tf 0.371 0 Td <0246>Tj 0.867 0 Td <025F>Tj 0.496 0 Td <0263>Tj 0.497 0 Td <025F>Tj 0.496 0 Td <026A>Tj /TT3 1 Tf 0.496 0 Td (\))Tj ET q 274.961 144.201 221.102 165.49 re W n 0.884 0.769 0 0 K /GS0 gs q 1 0 0 1 360.7329 296.0419 cm 0 0 m 0 0.464 0.372 0.836 0.836 0.836 c 1.3 0.836 1.672 0.464 1.672 0 c 1.672 -0.464 1.3 -0.836 0.836 -0.836 c 0.372 -0.836 0 -0.464 0 0 c h S Q Q BT /C2_3 1 Tf 4.495 0 0 4.6519 366.2751 294.0946 Tm <0241>Tj 0.619 0 Td <025A>Tj 0.496 0 Td <025C>Tj 0.496 0 Td <025F>Tj 0.496 0 Td <026A>Tj 0.496 0 Td <0272>Tj /TT3 1 Tf 0.744 0 Td (.)Tj 0.249 0 Td ( )Tj 0.249 0 Td ( )Tj 0.249 0 Td ( )Tj ET 0.884 0.769 0 0 k /GS0 gs q 1 0 0 1 389.1195 295.7634 cm 0 0 m 2.228 0 l h f Q 0.884 0.769 0 0 K 0.279 w q 1 0 0 1 389.1194 295.7632 cm 0 0 m 2.228 0 l 0 0 l h S Q q 1 0 0 1 390.2337 294.6483 cm 0 0 m 0 2.229 l h f Q q 1 0 0 1 390.2339 296.8774 cm 0 0 m 0 0 l 0 -2.229 l 0 0 l h S Q BT 0 0 0 1 k /GS1 gs /C2_3 1 Tf 4.495 0 0 4.6519 395.0495 294.0946 Tm <0250>Tj 0.743 0 Td <025F>Tj 0.496 0 Td <0267>Tj 0.496 0 Td <0261>Tj 0.495 0 Td <026D>Tj 0.372 0 Td <026A>Tj 0.496 0 Td <0262>Tj 0.497 0 Td <026A>Tj /TT3 1 Tf 0.496 0 Td (.)Tj ET 0 0 0 0 k /GS0 gs 296.689 289.635 194.916 -127.05 re f* 0 0 0 0.25 K q 1 0 0 1 301.4249 163.1423 cm 0 0 m 0 126.493 l S Q q 1 0 0 1 320.3678 163.1423 cm 0 0 m 0 126.493 l S Q q 1 0 0 1 339.3387 163.1423 cm 0 0 m 0 126.493 l S Q q 1 0 0 1 358.3093 163.1423 cm 0 0 m 0 126.493 l S Q q 1 0 0 1 377.2521 163.1423 cm 0 0 m 0 126.493 l S Q q 1 0 0 1 396.2227 163.1423 cm 0 0 m 0 126.493 l S Q q 1 0 0 1 415.1933 163.1423 cm 0 0 m 0 126.493 l S Q q 1 0 0 1 434.1362 163.1423 cm 0 0 m 0 126.493 l S Q q 1 0 0 1 453.1073 163.1423 cm 0 0 m 0 126.493 l S Q q 1 0 0 1 472.0779 163.1423 cm 0 0 m 0 126.493 l S Q q 1 0 0 1 296.6892 174.1178 cm 0 0 m 194.359 0 l S Q q 1 0 0 1 296.6892 185.1205 cm 0 0 m 194.359 0 l S Q q 1 0 0 1 296.6892 196.1231 cm 0 0 m 194.359 0 l S Q q 1 0 0 1 296.6892 207.1268 cm 0 0 m 194.359 0 l S Q q 1 0 0 1 296.6892 218.1295 cm 0 0 m 194.359 0 l S Q q 1 0 0 1 296.6892 229.1324 cm 0 0 m 194.359 0 l S Q q 1 0 0 1 296.6892 240.1354 cm 0 0 m 194.359 0 l S Q q 1 0 0 1 296.6892 251.1106 cm 0 0 m 194.359 0 l S Q q 1 0 0 1 296.6892 262.1135 cm 0 0 m 194.359 0 l S Q q 1 0 0 1 296.6892 273.1164 cm 0 0 m 194.359 0 l S Q q 1 0 0 1 296.6892 284.1196 cm 0 0 m 194.359 0 l S Q 0.884 0.769 0 0 K 0.557 w q 1 0 0 1 301.4249 284.1196 cm 0 0 m 0.418 0 l 0.418 -4.569 l 2.312 -4.569 l 2.312 -9.164 l 3.622 -9.164 l 3.622 -13.761 l 4.791 -13.761 l 4.791 -18.329 l 5.906 -18.329 l 5.906 -22.925 l 7.605 -22.925 l 7.605 -27.494 l 16.77 -27.494 l 16.77 -32.09 l 19.026 -32.09 l 19.026 -36.658 l 21.45 -36.658 l 21.45 -41.254 l 21.45 -45.822 l 27.495 -45.822 l 27.495 -50.419 l 57.135 -50.419 l 58.806 -50.419 l 59.001 -50.419 l 69.837 -50.419 l 73.404 -50.419 l 74.657 -50.419 l 75.66 -50.419 l 76.718 -50.419 l 103.907 -50.419 l 125.357 -50.419 l 141.403 -50.419 l 162.714 -50.419 l 166.669 -50.419 l S Q 0.884 0.769 0 0 k q 1 0 0 1 357.39 233.9235 cm 0 0 m 2.228 0 l h f Q 0.279 w q 1 0 0 1 357.39 233.9236 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 358.5042 232.8093 cm 0 0 m 0 2.228 l h f Q q 1 0 0 1 358.5044 235.0378 cm 0 0 m 0 0 l 0 -2.228 l 0 0 l h S Q q 1 0 0 1 359.0613 233.9235 cm 0 0 m 2.228 0 l h f Q q 1 0 0 1 359.0613 233.9236 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 360.1755 232.8093 cm 0 0 m 0 2.228 l h f Q q 1 0 0 1 360.1757 235.0378 cm 0 0 m 0 0 l 0 -2.228 l 0 0 l h S Q q 1 0 0 1 359.0613 233.9235 cm 0 0 m 2.228 0 l h f Q q 1 0 0 1 359.0613 233.9236 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 360.1755 232.8093 cm 0 0 m 0 2.228 l h f Q q 1 0 0 1 360.1757 235.0378 cm 0 0 m 0 0 l 0 -2.228 l 0 0 l h S Q q 1 0 0 1 370.2042 233.9235 cm 0 0 m 2.229 0 l h f Q q 1 0 0 1 370.2043 233.9236 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 371.3184 232.8093 cm 0 0 m 0 2.228 l h f Q q 1 0 0 1 371.3185 235.0378 cm 0 0 m 0 0 l 0 -2.228 l 0 0 l h S Q q 1 0 0 1 373.5468 233.9235 cm 0 0 m 2.229 0 l h f Q q 1 0 0 1 373.547 233.9236 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 374.661 232.8093 cm 0 0 m 0 2.228 l h f Q q 1 0 0 1 374.6614 235.0378 cm 0 0 m 0 0 l 0 -2.228 l 0 0 l h S Q q 1 0 0 1 375.219 233.9235 cm 0 0 m 2.228 0 l h f Q q 1 0 0 1 375.2187 233.9236 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 376.3332 232.8093 cm 0 0 m 0 2.228 l h f Q q 1 0 0 1 376.3328 235.0378 cm 0 0 m 0 0 l 0 -2.228 l 0 0 l h S Q q 1 0 0 1 375.7752 233.9235 cm 0 0 m 2.229 0 l h f Q q 1 0 0 1 375.7756 233.9236 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 376.8903 232.8093 cm 0 0 m 0 2.228 l h f Q q 1 0 0 1 376.89 235.0378 cm 0 0 m 0 0 l 0 -2.228 l 0 0 l h S Q q 1 0 0 1 376.8903 233.9235 cm 0 0 m 2.228 0 l h f Q q 1 0 0 1 376.89 233.9236 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 378.0045 232.8093 cm 0 0 m 0 2.228 l h f Q q 1 0 0 1 378.0041 235.0378 cm 0 0 m 0 0 l 0 -2.228 l 0 0 l h S Q q 1 0 0 1 404.1621 233.9235 cm 0 0 m 2.228 0 l h f Q q 1 0 0 1 404.1624 233.9236 cm 0 0 m 2.228 0 l 0 0 l h S Q q 1 0 0 1 405.2763 232.8093 cm 0 0 m 0 2.228 l h f Q q 1 0 0 1 405.2762 235.0378 cm 0 0 m 0 0 l 0 -2.228 l 0 0 l h S Q q 1 0 0 1 425.8908 233.9235 cm 0 0 m 2.228 0 l h f Q q 1 0 0 1 425.8907 233.9236 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 427.005 232.8093 cm 0 0 m 0 2.228 l h f Q q 1 0 0 1 427.0051 235.0378 cm 0 0 m 0 0 l 0 -2.228 l 0 0 l h S Q q 1 0 0 1 441.4905 233.9235 cm 0 0 m 2.228 0 l h f Q q 1 0 0 1 441.4908 233.9236 cm 0 0 m 2.228 0 l 0 0 l h S Q q 1 0 0 1 442.6047 232.8093 cm 0 0 m 0 2.228 l h f Q q 1 0 0 1 442.6047 235.0378 cm 0 0 m 0 0 l 0 -2.228 l 0 0 l h S Q q 1 0 0 1 463.1913 233.9235 cm 0 0 m 2.228 0 l h f Q q 1 0 0 1 463.1914 233.9236 cm 0 0 m 2.228 0 l 0 0 l h S Q q 1 0 0 1 464.3055 232.8093 cm 0 0 m 0 2.228 l h f Q q 1 0 0 1 464.3058 235.0378 cm 0 0 m 0 0 l 0 -2.228 l 0 0 l h S Q q 1 0 0 1 467.091 233.9235 cm 0 0 m 2.229 0 l h f Q q 1 0 0 1 467.0913 233.9236 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 468.2061 232.8093 cm 0 0 m 0 2.228 l h f Q q 1 0 0 1 468.2057 235.0378 cm 0 0 m 0 0 l 0 -2.228 l 0 0 l h S Q q 274.961 144.201 221.102 165.49 re W n 0.557 w q 1 0 0 1 300.5891 279.8856 cm 0 0 m 0 0.464 0.372 0.836 0.836 0.836 c 1.3 0.836 1.672 0.464 1.672 0 c 1.672 -0.464 1.3 -0.836 0.836 -0.836 c 0.372 -0.836 0 -0.464 0 0 c h S Q q 1 0 0 1 302.8177 275.4285 cm 0 0 m 0 0.464 0.372 0.836 0.836 0.836 c 1.3 0.836 1.672 0.464 1.672 0 c 1.672 -0.464 1.3 -0.836 0.836 -0.836 c 0.372 -0.836 0 -0.464 0 0 c h S Q q 1 0 0 1 303.9321 270.4144 cm 0 0 m 0 0.464 0.372 0.836 0.836 0.836 c 1.3 0.836 1.672 0.464 1.672 0 c 1.672 -0.464 1.3 -0.836 0.836 -0.836 c 0.372 -0.836 0 -0.464 0 0 c h S Q q 1 0 0 1 305.0465 265.9576 cm 0 0 m 0 0.464 0.372 0.836 0.836 0.836 c 1.3 0.836 1.672 0.464 1.672 0 c 1.672 -0.464 1.3 -0.836 0.836 -0.836 c 0.372 -0.836 0 -0.464 0 0 c h S Q q 1 0 0 1 306.1607 261.5007 cm 0 0 m 0 0.464 0.372 0.836 0.836 0.836 c 1.3 0.836 1.672 0.464 1.672 0 c 1.672 -0.464 1.3 -0.836 0.836 -0.836 c 0.372 -0.836 0 -0.464 0 0 c h S Q q 1 0 0 1 307.832 257.0439 cm 0 0 m 0 0.464 0.372 0.836 0.836 0.836 c 1.3 0.836 1.672 0.464 1.672 0 c 1.672 -0.464 1.3 -0.836 0.836 -0.836 c 0.372 -0.836 0 -0.464 0 0 c h S Q q 1 0 0 1 317.2757 252.0299 cm 0 0 m 0 0.464 0.372 0.836 0.836 0.836 c 1.3 0.836 1.672 0.464 1.672 0 c 1.672 -0.464 1.3 -0.836 0.836 -0.836 c 0.372 -0.836 0 -0.464 0 0 c h S Q q 1 0 0 1 319.5042 247.573 cm 0 0 m 0 0.464 0.372 0.836 0.836 0.836 c 1.3 0.836 1.672 0.464 1.672 0 c 1.672 -0.464 1.3 -0.836 0.836 -0.836 c 0.372 -0.836 0 -0.464 0 0 c h S Q q 1 0 0 1 321.7328 243.1159 cm 0 0 m 0 0.464 0.372 0.836 0.836 0.836 c 1.3 0.836 1.672 0.464 1.672 0 c 1.672 -0.464 1.3 -0.836 0.836 -0.836 c 0.372 -0.836 0 -0.464 0 0 c h S Q q 1 0 0 1 321.7328 238.6591 cm 0 0 m 0 0.464 0.372 0.836 0.836 0.836 c 1.3 0.836 1.672 0.464 1.672 0 c 1.672 -0.464 1.3 -0.836 0.836 -0.836 c 0.372 -0.836 0 -0.464 0 0 c h S Q q 1 0 0 1 327.8615 234.2022 cm 0 0 m 0 0.464 0.372 0.836 0.836 0.836 c 1.3 0.836 1.672 0.464 1.672 0 c 1.672 -0.464 1.3 -0.836 0.836 -0.836 c 0.372 -0.836 0 -0.464 0 0 c h S Q Q 0 0.994 1 0 K 0.557 w q 1 0 0 1 301.4249 284.1196 cm 0 0 m 2.507 -0.056 l S Q q 1 0 0 1 304.4893 282.3925 cm 0 0 m 0.056 -1.811 l S Q q 1 0 0 1 304.5451 280.5818 cm 0 0 m 0.362 0 l S Q q 1 0 0 1 304.9072 280.5818 cm 0 0 m 0.139 0.139 l S Q q 1 0 0 1 305.0465 278.4926 cm 0 0 m -0.139 -1.476 l S Q q 1 0 0 1 304.9072 277.0163 cm 0 0 m 0.613 0 l S Q q 1 0 0 1 305.52 277.0163 cm 0 0 m 0.084 -0.195 l S Q q 1 0 0 1 305.6035 274.5929 cm 0 0 m -0.084 -1.114 l S Q q 1 0 0 1 305.52 273.4788 cm 0 0 m 1.198 0 l S Q q 1 0 0 1 308.3893 272.9216 cm 0 0 m 0 -2.229 l S Q q 1 0 0 1 310.0606 270.1361 cm 0 0 m 0 -2.229 l S Q q 1 0 0 1 310.6178 266.2362 cm 0 0 m 0.39 0.139 l S Q q 1 0 0 1 311.0079 266.3755 cm 0 0 m 0.167 -1.811 l S Q q 1 0 0 1 311.7322 262.8935 cm 0 0 m 0 -2.229 l S Q q 1 0 0 1 311.7322 258.4366 cm 0 0 m 0 -2.229 l S Q q 1 0 0 1 313.3758 255.6509 cm 0 0 m 1.644 0.084 l S Q q 1 0 0 1 315.0194 255.7347 cm 0 0 m 0.028 -0.641 l S Q q 1 0 0 1 315.0471 252.8654 cm 0 0 m -0.028 -0.669 l S Q q 1 0 0 1 315.0194 252.1969 cm 0 0 m 1.699 0.111 l S Q q 1 0 0 1 318.3901 251.7513 cm 0 0 m 0 -2.229 l S Q q 1 0 0 1 318.3901 247.2944 cm 0 0 m 0 -2.201 l S Q q 1 0 0 1 318.3901 245.0936 cm 0 0 m 0 -0.028 l S Q q 1 0 0 1 320.0614 244.5087 cm 0 0 m 0 -2.228 l S Q q 1 0 0 1 321.7328 241.7232 cm 0 0 m 2.145 -0.167 l S Q q 1 0 0 1 323.8778 241.5562 cm 0 0 m 0.084 0.167 l S Q q 1 0 0 1 323.9613 239.4946 cm 0 0 m -0.084 -1.504 l S Q q 1 0 0 1 323.8778 237.9906 cm 0 0 m 0.641 -0.167 l S Q q 1 0 0 1 325.0757 236.1523 cm 0 0 m 0.056 -1.699 l S Q q 1 0 0 1 325.1315 234.4529 cm 0 0 m 0.501 0.028 l S Q q 1 0 0 1 326.1899 232.8095 cm 0 0 m 0.167 -1.922 l S Q q 1 0 0 1 326.3572 230.8873 cm 0 0 m 0.39 0.251 l S Q q 1 0 0 1 328.9757 231.1382 cm 0 0 m 2.451 -0.251 l S Q q 1 0 0 1 331.4271 230.8873 cm 0 0 m -0.223 0.251 l S Q q 1 0 0 1 331.2042 228.9096 cm 0 0 m 0.223 -1.56 l S Q q 1 0 0 1 331.4271 227.3498 cm 0 0 m 0.501 0 l S Q q 1 0 0 1 331.9285 227.3498 cm 0 0 m -0.167 -0.111 l S Q q 1 0 0 1 331.7614 224.9825 cm 0 0 m 0.167 -1.171 l S Q q 1 0 0 1 331.9285 223.8115 cm 0 0 m 1.114 0 l S Q q 1 0 0 1 333.0429 223.8115 cm 0 0 m -0.167 0.057 l S Q q 1 0 0 1 332.8756 221.6393 cm 0 0 m 0.167 -1.393 l S Q q 1 0 0 1 333.0429 220.2463 cm 0 0 m 0.39 -0.279 l S Q q 1 0 0 1 335.6613 219.9677 cm 0 0 m 2.229 0 l S Q q 1 0 0 1 340.1184 219.9677 cm 0 0 m 0.724 0.279 l S Q q 1 0 0 1 340.843 220.2463 cm 0 0 m -0.167 -1.949 l S Q q 1 0 0 1 341.2328 216.6255 cm 0 0 m 1.031 0.084 l S Q q 1 0 0 1 342.2635 216.7093 cm 0 0 m 0.084 -1.198 l S Q q 1 0 0 1 342.3473 213.2823 cm 0 0 m 2.229 0 l S Q q 1 0 0 1 346.8044 213.2823 cm 0 0 m 0 -2.228 l S Q q 1 0 0 1 347.3613 209.3829 cm 0 0 m 0 -2.229 l S Q q 1 0 0 1 347.9185 205.4835 cm 0 0 m 0.334 -0.139 l S Q q 1 0 0 1 348.2529 205.3442 cm 0 0 m 0.223 -1.532 l S Q q 1 0 0 1 348.4757 201.5831 cm 0 0 m 0.919 -0.139 l S Q q 1 0 0 1 349.3951 201.4438 cm 0 0 m 0.195 -0.975 l S Q q 1 0 0 1 349.5899 198.241 cm 0 0 m -0.195 -0.697 l S Q q 1 0 0 1 349.3951 197.5444 cm 0 0 m 1.867 0.139 l S Q q 1 0 0 1 352.9328 197.1265 cm 0 0 m 0 -2.229 l S Q q 1 0 0 1 352.9328 192.67 cm 0 0 m 2.229 0 l S Q q 1 0 0 1 357.39 192.67 cm 0 0 m 2.229 0 l S Q q 1 0 0 1 361.847 192.67 cm 0 0 m 0 -2.229 l S Q q 1 0 0 1 361.847 188.2123 cm 0 0 m 2.229 0 l S Q q 1 0 0 1 366.3042 188.2123 cm 0 0 m 1.226 -0.027 l S Q q 1 0 0 1 367.5299 188.1851 cm 0 0 m -0.111 -1.087 l S Q q 1 0 0 1 367.4186 184.8702 cm 0 0 m 0.111 -1.365 l S Q q 1 0 0 1 367.5299 183.5055 cm 0 0 m 0.446 -0.307 l S Q q 1 0 0 1 370.2043 183.1985 cm 0 0 m 2.229 0 l S Q q 1 0 0 1 374.6614 183.1985 cm 0 0 m 2.229 0 l S Q q 1 0 0 1 379.1185 183.1985 cm 0 0 m 2.229 0 l S Q q 1 0 0 1 383.5756 183.1985 cm 0 0 m 2.2 0 l S Q q 1 0 0 1 386.3334 181.5269 cm 0 0 m 0 -2.228 l S Q q 1 0 0 1 388.005 178.742 cm 0 0 m 2.229 0 l S Q q 1 0 0 1 392.4622 178.742 cm 0 0 m 2.229 0 l S Q q 1 0 0 1 396.9193 178.742 cm 0 0 m 2.229 0 l S Q q 1 0 0 1 401.3763 178.742 cm 0 0 m 2.229 0 l S Q q 1 0 0 1 405.8334 178.742 cm 0 0 m 2.229 0 l S Q q 1 0 0 1 410.2906 178.742 cm 0 0 m 2.229 0 l S Q q 1 0 0 1 414.7477 178.742 cm 0 0 m 2.229 0 l S Q q 1 0 0 1 419.2048 178.742 cm 0 0 m 2.229 0 l S Q q 1 0 0 1 423.6619 178.742 cm 0 0 m 2.229 0 l S Q 0 0.994 1 0 k q 1 0 0 1 343.4616 213.282 cm 0 0 m 2.228 0 l h f Q 0.279 w q 1 0 0 1 343.4614 213.2823 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 344.5758 212.1678 cm 0 0 m 0 2.229 l h f Q q 1 0 0 1 344.5758 214.3967 cm 0 0 m 0 0 l 0 -2.229 l 0 0 l h S Q q 1 0 0 1 351.2619 197.6841 cm 0 0 m 2.228 0 l h f Q q 1 0 0 1 351.2615 197.6837 cm 0 0 m 2.229 0 l 0 0 l h S Q q 1 0 0 1 352.3752 196.569 cm 0 0 m 0 2.229 l h f Q q 1 0 0 1 352.3756 198.7982 cm 0 0 m 0 0 l 0 -2.229 l 0 0 l h S Q q 1 0 0 1 426.4479 178.7418 cm 0 0 m 2.228 0 l h f Q q 1 0 0 1 426.4479 178.742 cm 0 0 m 2.228 0 l 0 0 l h S Q q 1 0 0 1 427.5621 177.6276 cm 0 0 m 0 2.228 l h f Q q 1 0 0 1 427.5623 179.8553 cm 0 0 m 0 0 l 0 -2.228 l 0 0 l h S Q q 274.961 144.201 221.102 165.49 re W n 0.557 w q 1 0 0 1 303.3749 280.9998 cm 0 0 m 0 0.464 0.372 0.836 0.836 0.836 c 1.3 0.836 1.672 0.464 1.672 0 c 1.672 -0.464 1.3 -0.836 0.836 -0.836 c 0.372 -0.836 0 -0.464 0 0 c h S Q q 1 0 0 1 303.9321 277.0999 cm 0 0 m 0 0.464 0.372 0.836 0.836 0.836 c 1.3 0.836 1.672 0.464 1.672 0 c 1.672 -0.464 1.3 -0.836 0.836 -0.836 c 0.372 -0.836 0 -0.464 0 0 c h S Q q 1 0 0 1 304.4893 273.7571 cm 0 0 m 0 0.464 0.372 0.836 0.836 0.836 c 1.3 0.836 1.672 0.464 1.672 0 c 1.672 -0.464 1.3 -0.836 0.836 -0.836 c 0.372 -0.836 0 -0.464 0 0 c h S Q q 1 0 0 1 307.2751 270.4144 cm 0 0 m 0 0.464 0.372 0.836 0.836 0.836 c 1.3 0.836 1.672 0.464 1.672 0 c 1.672 -0.464 1.3 -0.836 0.836 -0.836 c 0.372 -0.836 0 -0.464 0 0 c h S Q q 1 0 0 1 308.9464 266.5148 cm 0 0 m 0 0.464 0.372 0.836 0.836 0.836 c 1.3 0.836 1.672 0.464 1.672 0 c 1.672 -0.464 1.3 -0.836 0.836 -0.836 c 0.372 -0.836 0 -0.464 0 0 c h S Q q 1 0 0 1 310.0606 263.1721 cm 0 0 m 0 0.464 0.372 0.836 0.836 0.836 c 1.3 0.836 1.672 0.464 1.672 0 c 1.672 -0.464 1.3 -0.836 0.836 -0.836 c 0.372 -0.836 0 -0.464 0 0 c h S Q q 1 0 0 1 310.6178 259.2722 cm 0 0 m 0 0.464 0.366 0.836 0.822 0.836 c 1.278 0.836 1.644 0.464 1.644 0 c 1.644 -0.464 1.278 -0.836 0.822 -0.836 c 0.366 -0.836 0 -0.464 0 0 c h S Q q 1 0 0 1 310.6178 255.9295 cm 0 0 m 0 0.464 0.366 0.836 0.822 0.836 c 1.278 0.836 1.644 0.464 1.644 0 c 1.644 -0.464 1.278 -0.836 0.822 -0.836 c 0.366 -0.836 0 -0.464 0 0 c h S Q q 1 0 0 1 313.9327 252.5868 cm 0 0 m 0 0.464 0.372 0.836 0.836 0.836 c 1.3 0.836 1.672 0.464 1.672 0 c 1.672 -0.464 1.3 -0.836 0.836 -0.836 c 0.372 -0.836 0 -0.464 0 0 c h S Q q 1 0 0 1 317.2757 248.6872 cm 0 0 m 0 0.464 0.372 0.836 0.836 0.836 c 1.3 0.836 1.672 0.464 1.672 0 c 1.672 -0.464 1.3 -0.836 0.836 -0.836 c 0.372 -0.836 0 -0.464 0 0 c h S Q q 1 0 0 1 317.2757 245.3445 cm 0 0 m 0 0.464 0.372 0.836 0.836 0.836 c 1.3 0.836 1.672 0.464 1.672 0 c 1.672 -0.464 1.3 -0.836 0.836 -0.836 c 0.372 -0.836 0 -0.464 0 0 c h S Q q 1 0 0 1 318.947 242.0018 cm 0 0 m 0 0.464 0.372 0.836 0.836 0.836 c 1.3 0.836 1.672 0.464 1.672 0 c 1.672 -0.464 1.3 -0.836 0.836 -0.836 c 0.372 -0.836 0 -0.464 0 0 c h S Q q 1 0 0 1 322.8472 238.1019 cm 0 0 m 0 0.464 0.372 0.836 0.836 0.836 c 1.3 0.836 1.672 0.464 1.672 0 c 1.672 -0.464 1.3 -0.836 0.836 -0.836 c 0.372 -0.836 0 -0.464 0 0 c h S Q q 1 0 0 1 323.9613 234.7592 cm 0 0 m 0 0.464 0.372 0.836 0.836 0.836 c 1.3 0.836 1.672 0.464 1.672 0 c 1.672 -0.464 1.3 -0.836 0.836 -0.836 c 0.372 -0.836 0 -0.464 0 0 c h S Q q 1 0 0 1 325.0757 231.4168 cm 0 0 m 0 0.464 0.372 0.836 0.836 0.836 c 1.3 0.836 1.672 0.464 1.672 0 c 1.672 -0.464 1.3 -0.836 0.836 -0.836 c 0.372 -0.836 0 -0.464 0 0 c h S Q q 1 0 0 1 330.0901 227.503 cm 0 0 m 0 0.472 0.372 0.849 0.836 0.849 c 1.3 0.849 1.672 0.472 1.672 0 c 1.672 -0.472 1.3 -0.85 0.836 -0.85 c 0.372 -0.85 0 -0.472 0 0 c h S Q q 1 0 0 1 330.647 224.1467 cm 0 0 m 0 0.464 0.372 0.836 0.836 0.836 c 1.3 0.836 1.672 0.464 1.672 0 c 1.672 -0.465 1.3 -0.836 0.836 -0.836 c 0.372 -0.836 0 -0.465 0 0 c h S Q q 1 0 0 1 331.7614 220.2463 cm 0 0 m 0 0.465 0.372 0.836 0.836 0.836 c 1.3 0.836 1.672 0.465 1.672 0 c 1.672 -0.464 1.3 -0.836 0.836 -0.836 c 0.372 -0.836 0 -0.464 0 0 c h S Q q 1 0 0 1 339.5615 216.9041 cm 0 0 m 0 0.464 0.372 0.836 0.836 0.836 c 1.3 0.836 1.672 0.464 1.672 0 c 1.672 -0.465 1.3 -0.836 0.836 -0.836 c 0.372 -0.836 0 -0.465 0 0 c h S Q q 1 0 0 1 341.2328 213.5609 cm 0 0 m 0 0.465 0.372 0.836 0.836 0.836 c 1.3 0.836 1.672 0.465 1.672 0 c 1.672 -0.464 1.3 -0.836 0.836 -0.836 c 0.372 -0.836 0 -0.464 0 0 c h S Q q 1 0 0 1 345.6899 209.6615 cm 0 0 m 0 0.464 0.372 0.836 0.836 0.836 c 1.3 0.836 1.672 0.464 1.672 0 c 1.672 -0.465 1.3 -0.836 0.836 -0.836 c 0.372 -0.836 0 -0.465 0 0 c h S Q q 1 0 0 1 346.2471 205.7611 cm 0 0 m 0 0.465 0.372 0.836 0.836 0.836 c 1.3 0.836 1.672 0.465 1.672 0 c 1.672 -0.464 1.3 -0.835 0.836 -0.835 c 0.372 -0.835 0 -0.464 0 0 c h S Q q 1 0 0 1 347.3613 201.8617 cm 0 0 m 0 0.465 0.372 0.836 0.836 0.836 c 1.3 0.836 1.672 0.465 1.672 0 c 1.672 -0.465 1.3 -0.836 0.836 -0.836 c 0.372 -0.836 0 -0.465 0 0 c h S Q q 1 0 0 1 348.4757 197.9624 cm 0 0 m 0 0.464 0.372 0.836 0.836 0.836 c 1.3 0.836 1.672 0.464 1.672 0 c 1.672 -0.465 1.3 -0.836 0.836 -0.836 c 0.372 -0.836 0 -0.465 0 0 c h S Q q 1 0 0 1 351.8187 192.9475 cm 0 0 m 0 0.465 0.372 0.836 0.836 0.836 c 1.3 0.836 1.672 0.465 1.672 0 c 1.672 -0.464 1.3 -0.835 0.836 -0.835 c 0.372 -0.835 0 -0.464 0 0 c h S Q q 1 0 0 1 360.7329 188.4909 cm 0 0 m 0 0.465 0.372 0.836 0.836 0.836 c 1.3 0.836 1.672 0.465 1.672 0 c 1.672 -0.464 1.3 -0.836 0.836 -0.836 c 0.372 -0.836 0 -0.464 0 0 c h S Q q 1 0 0 1 366.3042 183.4772 cm 0 0 m 0 0.465 0.372 0.836 0.836 0.836 c 1.3 0.836 1.672 0.465 1.672 0 c 1.672 -0.465 1.3 -0.836 0.836 -0.836 c 0.372 -0.836 0 -0.465 0 0 c h S Q q 1 0 0 1 385.2473 179.0206 cm 0 0 m 0 0.464 0.365 0.835 0.822 0.835 c 1.278 0.835 1.643 0.464 1.643 0 c 1.643 -0.465 1.278 -0.836 0.822 -0.836 c 0.365 -0.836 0 -0.465 0 0 c h S Q Q 0 0 0 1 K 0.557 w /GS1 gs q 1 0 0 1 296.6892 163.1423 cm 0 0 m 194.331 0 l S Q q 1 0 0 1 301.4249 164.2568 cm 0 0 m 0 -1.114 l S Q q 1 0 0 1 320.3678 164.2568 cm 0 0 m 0 -1.114 l S Q q 1 0 0 1 339.3387 164.2568 cm 0 0 m 0 -1.114 l S Q q 1 0 0 1 358.3093 164.2568 cm 0 0 m 0 -1.114 l S Q q 1 0 0 1 377.2521 164.2568 cm 0 0 m 0 -1.114 l S Q q 1 0 0 1 396.2227 164.2568 cm 0 0 m 0 -1.114 l S Q q 1 0 0 1 415.1933 164.2568 cm 0 0 m 0 -1.114 l S Q q 1 0 0 1 434.1362 164.2568 cm 0 0 m 0 -1.114 l S Q q 1 0 0 1 453.1073 164.2568 cm 0 0 m 0 -1.114 l S Q q 1 0 0 1 472.0779 164.2568 cm 0 0 m 0 -1.114 l S Q q 1 0 0 1 491.0208 164.2568 cm 0 0 m 0 -1.114 l S Q BT 0 0 0 1 k /TT3 1 Tf 4.495 0 0 4.6519 300.3114 156.7127 Tm (0)Tj 3.966 0 Td (1)Tj 0.496 0 Td (0)Tj 3.724 0 Td (2)Tj 0.496 0 Td (0)Tj 3.724 0 Td (3)Tj 0.496 0 Td (0)Tj 3.718 0 Td (4)Tj 0.496 0 Td (0)Tj 3.724 0 Td (5)Tj 0.496 0 Td (0)Tj 3.724 0 Td (6)Tj 0.496 0 Td (0)Tj 3.719 0 Td (7)Tj 0.496 0 Td (0)Tj 3.723 0 Td (8)Tj 0.496 0 Td (0)Tj 3.724 0 Td (9)Tj 0.496 0 Td (0)Tj 3.471 0 Td (1)Tj 0.496 0 Td (0)Tj 0.496 0 Td (0)Tj /C2_3 1 Tf -30.232 -1.857 Td <023C>Tj 0.62 0 Td <026A>Tj 0.496 0 Td <025F>Tj 0.496 0 Td <0266>Tj 0.744 0 Td <0279>Tj /TT3 1 Tf 0.496 0 Td ( )Tj /C2_3 1 Tf 0.249 0 Td <0268>Tj 0.496 0 Td <026C>Tj /TT3 1 Tf 0.495 0 Td ( )Tj /C2_3 1 Tf 0.249 0 Td <0269>Tj 0.497 0 Td <026A>Tj 0.496 0 Td <0268>Tj 0.496 0 Td <025C>Tj 0.496 0 Td <025F>Tj 0.496 0 Td <025E>Tj 0.62 0 Td <025F>Tj 0.496 0 Td <0267>Tj 0.49 0 Td <0267>Tj 0.496 0 Td <0268>Tj 0.496 0 Td <0263>Tj /TT3 1 Tf 0.497 0 Td ( )Tj /C2_3 1 Tf 0.249 0 Td <0268>Tj 0.496 0 Td <0269>Tj 0.496 0 Td <025F>Tj 0.496 0 Td <026A>Tj 0.496 0 Td <025A>Tj 0.496 0 Td <0270>Tj 0.619 0 Td <0262>Tj 0.497 0 Td <0262>Tj /TT3 1 Tf 0.497 0 Td (,)Tj 0.249 0 Td ( )Tj /C2_3 1 Tf 0.249 0 Td <0266>Tj 0.744 0 Td <025F>Tj 0.496 0 Td <026B>Tj /TT3 1 Tf 0.496 0 Td (.)Tj ET q 1 0 0 1 296.6892 289.635 cm 0 0 m 194.331 0 l S Q q 1 0 0 1 301.4249 288.4929 cm 0 0 m 0 1.142 l S Q q 1 0 0 1 320.3678 288.4929 cm 0 0 m 0 1.142 l S Q q 1 0 0 1 339.3387 288.4929 cm 0 0 m 0 1.142 l S Q q 1 0 0 1 358.3093 288.4929 cm 0 0 m 0 1.142 l S Q q 1 0 0 1 377.2521 288.4929 cm 0 0 m 0 1.142 l S Q q 1 0 0 1 396.2227 288.4929 cm 0 0 m 0 1.142 l S Q q 1 0 0 1 415.1933 288.4929 cm 0 0 m 0 1.142 l S Q q 1 0 0 1 434.1362 288.4929 cm 0 0 m 0 1.142 l S Q q 1 0 0 1 453.1073 288.4929 cm 0 0 m 0 1.142 l S Q q 1 0 0 1 472.0779 288.4929 cm 0 0 m 0 1.142 l S Q q 1 0 0 1 491.0208 288.4929 cm 0 0 m 0 1.142 l S Q q 1 0 0 1 296.6892 163.1423 cm 0 0 m 0 126.493 l S Q q 1 0 0 1 297.7756 163.1141 cm 0 0 m -1.087 0 l S Q q 1 0 0 1 297.7756 174.1178 cm 0 0 m -1.087 0 l S Q q 1 0 0 1 297.7756 185.1205 cm 0 0 m -1.087 0 l S Q q 1 0 0 1 297.7756 196.1231 cm 0 0 m -1.087 0 l S Q q 1 0 0 1 297.7756 207.1268 cm 0 0 m -1.087 0 l S Q q 1 0 0 1 297.7756 218.1295 cm 0 0 m -1.087 0 l S Q q 1 0 0 1 297.7756 229.1324 cm 0 0 m -1.087 0 l S Q q 1 0 0 1 297.7756 240.1354 cm 0 0 m -1.087 0 l S Q q 1 0 0 1 297.7756 251.1106 cm 0 0 m -1.087 0 l S Q q 1 0 0 1 297.7756 262.1135 cm 0 0 m -1.087 0 l S Q q 1 0 0 1 297.7756 273.1164 cm 0 0 m -1.087 0 l S Q q 1 0 0 1 297.7756 284.1196 cm 0 0 m -1.087 0 l S Q BT /TT3 1 Tf 4.495 0 0 4.6519 287.2126 161.7233 Tm (-)Tj 0.371 0 Td (0)Tj 0.496 0 Td (,)Tj 0.249 0 Td (1)Tj -0.743 2.366 Td (0)Tj 0.496 0 Td (,)Tj 0.249 0 Td (0)Tj -0.745 2.365 Td (0)Tj 0.496 0 Td (,)Tj 0.249 0 Td (1)Tj -0.745 2.366 Td (0)Tj 0.496 0 Td (,)Tj 0.249 0 Td (2)Tj -0.745 2.365 Td (0)Tj 0.496 0 Td (,)Tj 0.249 0 Td (3)Tj -0.745 2.367 Td (0)Tj 0.496 0 Td (,)Tj 0.249 0 Td (4)Tj -0.745 2.366 Td (0)Tj 0.496 0 Td (,)Tj 0.249 0 Td (5)Tj -0.745 2.365 Td (0)Tj 0.496 0 Td (,)Tj 0.249 0 Td (6)Tj -0.745 2.359 Td (0)Tj 0.496 0 Td (,)Tj 0.249 0 Td (7)Tj -0.745 2.366 Td (0)Tj 0.496 0 Td (,)Tj 0.249 0 Td (8)Tj -0.745 2.365 Td (0)Tj 0.496 0 Td (,)Tj 0.249 0 Td (9)Tj -0.745 2.365 Td (1)Tj 0.496 0 Td (,)Tj 0.249 0 Td (0)Tj /C2_3 1 Tf 0 4.6521 -4.6521 0 282.1978 192.387 Tm <0244>Tj 0.599 0 Td <026D>Tj 0.48 0 Td <0266>Tj 0.718 0 Td <026D>Tj 0.48 0 Td <0265>Tj 0.599 0 Td <0279>Tj 0.599 0 Td <026C>Tj 0.479 0 Td <0262>Tj 0.599 0 Td <025C>Tj 0.479 0 Td <0267>Tj 0.598 0 Td <025A>Tj 0.598 0 Td <0279>Tj /TT3 1 Tf 0.599 0 Td ( )Tj /C2_3 1 Tf 0.24 0 Td <025E>Tj 0.598 0 Td <0268>Tj 0.598 0 Td <0265>Tj 0.598 0 Td <0279>Tj /TT3 1 Tf 0.599 0 Td ( )Tj /C2_3 1 Tf 0.24 0 Td <025C>Tj 0.479 0 Td <0275>Tj <0260>Tj 1.437 0 Td <0262>Tj 0.599 0 Td <025C>Tj 0.479 0 Td <0272>Tj 0.838 0 Td <0262>Tj 0.599 0 Td <026F>Tj ET q 1 0 0 1 491.0485 163.1423 cm 0 0 m 0 126.493 l S Q q 1 0 0 1 489.9341 163.1141 cm 0 0 m 1.087 0 l S Q q 1 0 0 1 489.9341 174.1178 cm 0 0 m 1.114 0 l S Q q 1 0 0 1 489.9341 185.1205 cm 0 0 m 1.114 0 l S Q q 1 0 0 1 489.9341 196.1231 cm 0 0 m 1.114 0 l S Q q 1 0 0 1 489.9341 207.1268 cm 0 0 m 1.114 0 l S Q q 1 0 0 1 489.9341 218.1295 cm 0 0 m 1.114 0 l S Q q 1 0 0 1 489.9341 229.1324 cm 0 0 m 1.114 0 l S Q q 1 0 0 1 489.9341 240.1354 cm 0 0 m 1.114 0 l S Q q 1 0 0 1 489.9341 251.1106 cm 0 0 m 1.114 0 l S Q q 1 0 0 1 489.9341 262.1135 cm 0 0 m 1.114 0 l S Q q 1 0 0 1 489.9341 273.1164 cm 0 0 m 1.114 0 l S Q q 1 0 0 1 489.9341 284.1196 cm 0 0 m 1.114 0 l S Q 0.884 0.769 0 0 K /GS0 gs q 1 0 0 1 348.8379 276.0135 cm 0 0 m 7.438 0 l S Q BT /GS1 gs /TT3 1 Tf 4.495 0 0 4.6519 357.19 274.3486 Tm ( )Tj 0.249 0 Td ( )Tj /C2_3 1 Tf 0.247 0 Td <0249>Tj 0.743 0 Td <025A>Tj 0.496 0 Td <0270>Tj 0.619 0 Td <0262>Tj 0.497 0 Td <025F>Tj 0.496 0 Td <0267>Tj 0.496 0 Td <026C>Tj 0.495 0 Td <0275>Tj /TT3 1 Tf 0.743 0 Td ( )Tj /C2_3 1 Tf 0.249 0 Td <025B>Tj 0.619 0 Td <025F>Tj 0.496 0 Td <0261>Tj /TT3 1 Tf 0.495 0 Td ( )Tj /C2_3 1 Tf 0.249 0 Td <0266>Tj 0.743 0 Td <025F>Tj 0.496 0 Td <026C>Tj 0.489 0 Td <025A>Tj 0.496 0 Td <026B>Tj 0.496 0 Td <026C>Tj 0.495 0 Td <025A>Tj 0.496 0 Td <0261>Tj 0.495 0 Td <0268>Tj 0.496 0 Td <025C>Tj /TT3 1 Tf 0.496 0 Td ( )Tj /C2_3 1 Tf 0.249 0 Td <0269>Tj 0.497 0 Td <0268>Tj 0.496 0 Td <026B>Tj 0.496 0 Td <0265>Tj 0.62 0 Td <025F>Tj /TT3 1 Tf 0.496 0 Td ( )Tj /C2_3 1 Tf 0.249 0 Td <0268>Tj 0.496 0 Td <0269>Tj 0.497 0 Td <025F>Tj 0.496 0 Td <026A>Tj 0.496 0 Td <025A>Tj 0.496 0 Td <0270>Tj 0.619 0 Td <0262>Tj 0.497 0 Td <0262>Tj ET 0 0.994 1 0 K /GS0 gs q 1 0 0 1 348.8379 270.3032 cm 0 0 m 2.424 -0.167 l S Q q 1 0 0 1 353.4901 270.1361 cm 0 0 m 2.229 0 l S Q BT /GS1 gs /TT3 1 Tf 4.495 0 0 4.6519 357.19 268.6329 Tm ( )Tj 0.249 0 Td ( )Tj /C2_3 1 Tf 0.249 0 Td <0249>Tj 0.743 0 Td <025A>Tj 0.496 0 Td <0270>Tj 0.619 0 Td <0262>Tj 0.497 0 Td <025F>Tj 0.496 0 Td <0267>Tj 0.496 0 Td <026C>Tj 0.495 0 Td <0275>Tj /TT3 1 Tf 0.743 0 Td ( )Tj /C2_3 1 Tf 0.249 0 Td <026B>Tj /TT3 1 Tf 0.496 0 Td ( )Tj /C2_3 1 Tf 0.249 0 Td <0266>Tj 0.744 0 Td <025F>Tj 0.496 0 Td <026C>Tj 0.495 0 Td <025A>Tj 0.49 0 Td <026B>Tj 0.496 0 Td <026C>Tj 0.495 0 Td <025A>Tj 0.496 0 Td <0261>Tj 0.495 0 Td <025A>Tj 0.496 0 Td <0266>Tj 0.743 0 Td <0262>Tj /TT3 1 Tf 0.497 0 Td ( )Tj /C2_3 1 Tf 0.249 0 Td <025C>Tj /TT3 1 Tf 0.496 0 Td ( )Tj /C2_3 1 Tf 0.249 0 Td <0269>Tj 0.496 0 Td <025F>Tj 0.496 0 Td <0271>Tj 0.496 0 Td <025F>Tj 0.496 0 Td <0267>Tj 0.496 0 Td <0276>Tj /TT3 1 Tf 0.496 0 Td ( )Tj /C2_3 1 Tf 0.249 0 Td <0269>Tj 0.496 0 Td <0268>Tj 0.496 0 Td <026B>Tj 0.496 0 Td <0265>Tj 0.619 0 Td <025F>Tj /TT3 1 Tf 0.496 0 Td ( )Tj /C2_3 1 Tf 0.249 0 Td <0268>Tj 0.496 0 Td <0269>Tj 0.496 0 Td <025F>Tj 0.496 0 Td <026A>Tj 0.496 0 Td <025A>Tj 0.496 0 Td <0270>Tj 0.619 0 Td <0262>Tj 0.497 0 Td <0262>Tj ET EMC BT 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0.018 Tw 9 0 0 9 274.9606 133.3959 Tm (\022\t\217\210\b\002\220 4.)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf ( \216\020\204\025\027\026\031\003\n\t\024\022 \005\n\023\022\021\020\004\ \003\031\024\026\t\024\026\024\025\006\031\t\013\025\003 \032\026)Tj 0 Tw (-)Tj 0.002 Tw T* (\013\n\003 \033\032\002\003\n\017 \013\025\001\013\025 \027)Tj /Span<>> BDC ( )Tj EMC (\016\026\027\025\t\025\003\n\t\024\025 \n\024 \021\026\023\025\006\025\002\ \003\031\024\026\t\024\026\024\025)Tj 0 Tw (-)Tj T* (\006\031\t\013\n\202\n \033\n\032\026\204\031\021\025\002 \033\031\006\031\ \021\025 \033\n\t\023\031 \n\033\031\032\026\203\025\025)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0.057 Tw T* [(F)-16(igure 4.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf [( Sur)-42(viv)16(al rate of patients with metastatic rectal can)]TJ 0 Tw (-)Tj 0.007 Tw T* [(cer depending on the p)46(resence of metastatic liv)13(er d)26(amag)12(e af)-45.9(ter )]TJ 0 Tw T* [(surg)12(er)-43(y)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\033\030\031\030\213\b)-20.9(\035\231\213\233\t \021\032)50(\b)42(\032\231\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj /T1_4 1 Tf 25 0 0 25 512.7271 56.0378 Tm (55)Tj ET endstream endobj 2011 0 obj <> endobj 2012 0 obj <> endobj 2013 0 obj <> endobj 2014 0 obj <> endobj 2018 0 obj <>stream Adobe Illustrator CS6 (Windows) 2024-01-17T10:31:58+06:00 2024-01-17T10:34:43+05:00 2024-01-17T10:34:43+05:00 1 False True 139.983876 104.775000 Millimeters ArialMT Arial Regular Open Type Version 7.00 False arial.ttf Cyan Magenta Yellow Black Default Swatch Group 0 C=0 M=0 Y=0 K=100 CMYK PROCESS 0.000000 0.000000 0.000000 100.000000 C=0 M=99 Y=100 K=0 PROCESS 100.000000 CMYK 0.000000 99.398796 100.000000 0.000000 C=88 M=77 Y=0 K=0 PROCESS 100.000000 CMYK 88.366501 76.916100 0.000000 0.000000 C=0 M=0 Y=0 K=25 PROCESS 100.000000 CMYK 0.000000 0.000000 0.000000 25.000000 C=0 M=0 Y=0 K=0 CMYK PROCESS 0.000000 0.000000 0.000000 0.000000 C=0 M=1 Y=5 K=0 PROCESS 100.000000 CMYK 0.000000 0.802600 4.891997 0.000000 Document application/pdf 05_04 proof:pdf uuid:cf25442f-63b2-40f9-945f-410d062f41a4 uuid:fcd9cc44-44c1-4211-bd0d-c42b5a151676 Adobe PDF library 10.01 endstream endobj 2017 0 obj <>stream Adobe Illustrator CS6 (Windows) 2024-01-17T10:33:51+05:00 2024-01-17T10:34:25+05:00 2024-01-17T10:34:25+05:00 1 False True 139.983876 103.716667 Millimeters ArialMT Arial Regular Open Type Version 7.00 False arial.ttf Cyan Magenta Yellow Black Default Swatch Group 0 C=0 M=0 Y=0 K=100 CMYK PROCESS 0.000000 0.000000 0.000000 100.000000 C=0 M=99 Y=100 K=0 PROCESS 100.000000 CMYK 0.000000 99.398788 100.000000 0.000000 C=88 M=77 Y=0 K=0 PROCESS 100.000000 CMYK 88.366524 76.916145 0.000000 0.000000 C=0 M=0 Y=0 K=25 PROCESS 100.000000 CMYK 0.000000 0.000000 0.000000 25.000000 C=0 M=0 Y=0 K=0 CMYK PROCESS 0.000000 0.000000 0.000000 0.000000 C=0 M=1 Y=5 K=0 PROCESS 100.000000 CMYK 0.000000 0.802624 4.892039 0.000000 Document application/pdf proof:pdf uuid:0385cbab-dda7-4044-84ff-e325021302c6 uuid:89af7820-e032-4c98-830a-ad805ae908b9 endstream endobj 2016 0 obj <>stream Adobe Illustrator CS6 (Windows) 2024-01-17T10:36:38+06:00 2024-01-17T10:36:38+05:00 2024-01-17T10:36:38+05:00 1 False True 139.983876 104.775000 Millimeters ArialMT Arial Regular Open Type Version 7.00 False arial.ttf Magenta Yellow Black Default Swatch Group 0 C=0 M=0 Y=0 K=100 PROCESS 100.000000 CMYK 0.000000 0.000000 0.000000 100.000000 C=0 M=99 Y=100 K=0 PROCESS 100.000000 CMYK 0.000000 99.398788 100.000000 0.000000 C=0 M=0 Y=0 K=25 PROCESS 100.000000 CMYK 0.000000 0.000000 0.000000 25.000000 C=0 M=0 Y=0 K=0 CMYK PROCESS 0.000000 0.000000 0.000000 0.000000 C=0 M=1 Y=5 K=0 PROCESS 100.000000 CMYK 0.000000 0.802624 4.892039 0.000000 Document application/pdf 05_02 proof:pdf uuid:2236db54-0d8c-4937-9339-c7b6f5164841 uuid:c43c8210-a231-481d-8278-a6135d74e41c Adobe PDF library 10.01 endstream endobj 2015 0 obj <>stream Adobe Illustrator CS6 (Windows) 2024-01-17T10:38:25+06:00 2024-01-17T10:38:25+05:00 2024-01-17T10:38:25+05:00 1 False True 139.983876 104.775000 Millimeters ArialMT Arial Regular Open Type Version 7.00 False arial.ttf Magenta Yellow Black Default Swatch Group 0 C=0 M=0 Y=0 K=100 PROCESS 100.000000 CMYK 0.000000 0.000000 0.000000 100.000000 C=0 M=99 Y=100 K=0 PROCESS 100.000000 CMYK 0.000000 99.398788 100.000000 0.000000 C=0 M=0 Y=0 K=25 PROCESS 100.000000 CMYK 0.000000 0.000000 0.000000 25.000000 C=0 M=0 Y=0 K=0 CMYK PROCESS 0.000000 0.000000 0.000000 0.000000 C=0 M=1 Y=5 K=0 PROCESS 100.000000 CMYK 0.000000 0.802624 4.892039 0.000000 Document application/pdf 05_01 proof:pdf uuid:c12bb8aa-4894-40ec-ad58-52679a7457c0 uuid:3e247c31-988c-45e0-a796-6e5271111c7f Adobe PDF library 10.01 endstream endobj 2003 0 obj <> endobj 2004 0 obj <> endobj 2005 0 obj <> endobj 2006 0 obj <> endobj 2007 0 obj <> endobj 2008 0 obj <> endobj 2009 0 obj <> endobj 2010 0 obj <> endobj 2030 0 obj <> endobj 2031 0 obj <>stream H|y\SW'/BDD{ XQZ\iѱ.U RE[GTDTpWp .⮈+vI LmQkh@27N9s7fH#vp|2XGF)' y8h_Ï>:lx'1>=fO#'EM2uZ3f͞y |EI$y)+RWZ&}6flڼe+ع+3k<$9w4'O>s qJkoܼUzw**޻5bꖃAa S%ƨr@a0OHR4!K(^]QDq*ŗ̟955g5N}~+gWKҧi4^Z(J"=^JlMr7G+'q|9Q DCKh0F&  FƶF8a Tz(*Ex)>Jk_ R:+=%FIR%MYd)|H9+2[)jo 7E&fvNg6 CQ=!~vgmd˺^Խs:Zg_\ *j$ dNqG(^=a{1B\!׊sh)$dZK4D k8QJ Bz%C;rH=h9SL3)j800SLo؂Slc hnTOQ~ Ű&Jr NNO(S4)sn"-z{/N1>>^Y;E]H=7HrQt> @|::ju9:{Jm -iOPKe%b,?n6-K̴w1ݶmup^%iEK^Y bo[<;~#4yr<7zul0~wY} H`,Wc ؘ^lDcl8dv܍1EIBtTd֛5*PUT*Q%uY+ꪺuuCTꖪP3YU` 9B{:RGh@7ԍtnf:V溅Hh6\_RWuST9NS9'S :A'$StntLP/ "X/K2\+Jz^|^og%zSެ៶=v]z~W=@a8p6P}C_!}XG1>?֟O n1ܘpSnƱ͹s'r's 1;8{`\| {c?8p88 GpJjZX+'}2BF|*dl b="d $ElbrdcD6d#Bdȓe /ȧ(ԐQ 5&ԔQ,QsjA*JdJTjIiN2Q&Q+jMm(R;ʢԁԉ2YPJnu)zP\v.ˮC}/4 LCh( 4F(n5gfhn7!fffeF1f7{[-y%48Oh"@"&Ji4 ͤYLWUMџuȃհ:ȇ6&~a lmvNiWrW{>{LoojпC_ }5p^>ȇ2&$$ &bX*"OFU ^q@G1q\_o&ݴ1YwIqZ"qI\7D#=!+;>Ǹ~N<5P uSa B2Uf.&e̕e_9P X''T9C$_9WΗ "D.+¥Jke 7-r!.##iXt˿/MI)yVY*2Y.Jz%VUj(UjTsBūDRUPUکꬺ*[T=Uz>j!jjF1jT8}-X8GWd5MM8ʱÒp8X'IvR4'tڇ]8`g3Lr&;ӜPI4T*UjBOeF2MM3Q|nne2ߚ͏Lo7ۛS,?ǟ/+;*?_|h~6'/՜6gYs\0Eؔ撹lJs\3e溹anzmXEVUb].Yؖ mɶm۵C=۷#H;ʌ3^fUj] V`mL/eәs77%'$CR$!b 4bO1/!JQ2-1j P[$2XKP!t.z4Jֹl,ce5Iɠ<0*fM HD&Ȧl.el!_y~O}@?{O5Pg5\~/akڃ6<` tS3_73 tsP'EfN4%t V,܊םV"8 KXmt5K2|dVfج6kZ|b>5Qdg"nn_3Lyrm8%&L5t34l3䛹z/EbDM_qT^q(wwm?pA:̏BAUKZ 5ɢqgi_ʑ~5Γ%x/^]hޚM.եq!'?]U3%CGi~?_o@'P`*(o,C}]; 2 O\%(A h )J.=9dG̲S/Uf-c u%Sv!&21ERQ)Ћ1(Rk2q: xHa: *%Rox o>c߁%ѦФQ脻sZ>UŠLAW`+w.V̪DǴAF@P\7EG\A;4VzUƿ!`J|G0t/Cdܯ:5U5ߺ::z's( 0/*&DWkv8Vc7OM?ͼiw"3JYxtg ?.긥l+%G|lTjl^c>[aҩ_ĽЎP hj ⼗#H8 8nɈL\HU߾o}~] B_ta,Po2j2;@fɱr\.Snslꪆ*^uVjZUݲlk5m=j]G -0JuW|<|Ls)w"BEǥ ʔ)*6\1D}=j#p*=V cb62q: ͪ>ǥ}[)f` L5<*xy.˫P_5${ vմMd)$UZI,j%oL&.+:Gi<*Pz$Z9@E$5g, WY%Geʦ+Ll)CPiir6ڿ>@]du*Lۅ )IF^!VV  RKlΠ:IoJ?Fyq3ݢŴg&hʹɺ(ӝQ .tnt _R@]IRW|ޒ"*;UJ7l8u}1iP gb(KʬPQxSjxFqgvχ۳1Yܙ69{e/lLZBA R{-u+!CP%ND y$b >Ax6 49ɣ)Pd2y Zȣ-x!({\@L#n$N[ "(O@n܃U^p; uE4\IN[(r.c"9>ʃ s^J FC0<30 ș5M@){Pޱ DTkrFq(D%{Z͍0 j#+Zj5Gm68u, _xqD=pJ{Jry;l `',, f^"Ag].z,z,MM=iKQixW!C$brG,`8yasE4?ye|[VcWUE2gvo|6;B6&yӟ@8 bNyoN Qkb%SBMP`"["El!x懞fx]/ʂPf33W݋>֡Q!q(K0Lgx?iffnƻr":|65E5 D%6o7N:D"T9~j/`C]# I0B?,,qA/8+xpH*.l /7t&v;G&Ĺ ŃCx *]4?6|ZX0oPݡ2B`[DC~!QﲄQuuC$?eS|ͮsʳ.#AȾ$KÏ^ [?-[Ò#R9vGbH %ۖF4-$+2esu7Iu E>b=~-_o5:ַp7_nX֜9t r褈b4/Kx HjσPo:>n9n@0> hmji57pc|QN.uyAf'|y>9 )!f?Y[[oJ[|>W}>}dc:ݽ_~۱$mAXX͖:ԍQU +@HXPc@)+a :uLЕ!ek# ҆&@ -M&9zooWyZҫ\9O;$n>ui;Ȥ^y~[JPR=FEƟH,-,?V%Hw;uZ}]~Mg^}Hfc" @"îkuDWnM]L@jDC~GuN@[mQJ ﰂ^ ApZu)B\v(Pꊊ]v^K|Qhy_入T*-Er*n&P,..Vp%NpAhaLG i6VT@7tȬ6βt]"/9oWWnϹ6?†y2E]'&?xkW?h Sag VE9)nM2[DvU$KDP%L ּj|N*Ap׵<&==B88}Tr$|, $W"R\?OP;}ڷGsAyWpamJsn (:Kf,ȂWڰF|+|r ޡ W9EFbqBYsUӄ K'jwp /o IFSզEHp/*j˴vS'M ]հ? WCd}04 ]' \ll|>>7<\\I*ߠtA. ׇ^/ط*o%Wwq43 p2YHV *s9zzD|a1Ctצ]+ӝuh#x[]ji']d%G >4?>i3NJoߴlhgd͡( 3iV)3y)@|p|mDy>o-K( #NAf{%Z9+ )HMԤ[Pf57o=sRMA +Y N偏-'<?9yrvے/ Z?}p\8_$vL+`K7DS&C\_1G'zVh,C$L)i=5 kod^sP_3%VmLc=cMOW+K+~օǘS a?cv҈;O8Y: paO=])q6+=LyH:yG&ctXGy܊$O/;C g%peF=x,/{MN#O8֊P+ëOJ NQ'#a,Qfh3=!gX,ؐjdsRCR}q)Euݛ~{dcv^WxvW w/[wMokˆ_6.ٲuk-:8yJP@S:#I N& DD-~ "Zv?P?P|w}Jd?PcnK.qzJy`d!* nذ A"0Hp#!Q.hX dـ$inUuۜVW\i2ŭkR64+Y @nϐ3A.7=ͼmz&gmV->##EsٜP;='UUm|N"qstS9s6 s[v\$RQF B/]}+dE/jqF,dV+.O4c8 ʽwW5үW"  DKmAԆ'zQ! Ye<8ԜH$is Qt,+Ln\85Ƈ@5ٞM^uU;Gӏ5 >V) p0 t !8e 7K0D<5е.sma1Obp"1c$kX7e_{gk_iYZ) A&s{`FFXٯΔf'O׸sdgB(BA7HQ"#)zn68g_!/Uͩk(VN/|;gK]z[\ā5?8l|iȁ'&.x=}7HoVߦ8gqpQe1(Rf4ZYt&Nͨw֊FW]5C(?j9wהp^QUg;M6 YlHB!aPGИ)`(D0^BH1,(  C8-N-Tm)P*.uGo{=|=N40LӑQE9A#gXFu>s!~ʓXn\vsƴp})ƟFW {][!F=.l019OXTDݣfe-Zey 5YA*+:gu+ɫS"Wv38e„:XWQ$?m'9#tX[b);_r*e 85$&P$oM˯\)2m\S4fLey]w_˱o#*0e:}瞍o,&S{uBmnjf#_=&f[4[hW IS"4WQU>JYժJA`,E HݮoSj|o/y&W-1JW5!}mhayTÑ?1[=9qʿ6h8}I*Ukk(ʕ3+B2Nc(ee0'|9>*g2z ?ȏl?rT^jԂ@:w~ZWz/KvTİ1\⫦J܆;Ȁ{ZbÂ$8!8a韖rV2璴ϻ6FѪ8WIoqoL:)+*6ca_->Rn<1~ezzڢ@i'Ax=[lm~ىHMv۪PyVSASgMAcɐ& (-XF&e^MKJSrc  Dx0;%yvZ{Y',W&B(deX< [X E 0a2fʄ>h` ~OްpXziivyGNRzWVQC%w}tqܟ :xeWOiܺ5w⓷Tl+{6=+LүMEv/!JZry_D>IL_|پAiaOFnFeIS@gT .5)tiӥCd" βy9]5Ľr):PK>eJYj}踑9UoYn|+xǑHGmAudI+3fq]ՏOMd.^6wL6ZgQAi~id4[4HweȵZ^PhyAa/Om) M0,cT*?~3/b$>j2ji'* -fLS).I UgW:\ ?8͗پ#7o.{[W!Mߟ5 E2XO靭H8"gyF} 9گ dy~n;K'B8MxM@Qm?-EEj"0 r̶l(y)i35XoCs6 ތa@LBZ ~6C= j$ZVNlƹ>?`|0 X`ls>wQ@߫ Y;sxUhv ^Ԁ`A<}x(@0cmº+8ܔ7I&&33os:y~j0s0g;SKJ~7HdN%%|OAX%36K%.5i)GZ.}R%7lII9vcg9)hƫ[iUKL/Go+7)Ik)r;qNԣbhutvN鯝/N=}|L8ƒa?P3ůqX퇀U@glݎjDEZFQ h/ u3\CV)64fƣ8%KZ|MMNBߙj <NYhk}ћ,~>驼L2 [~6X1c$93VTiQ9_7t8ix|߫{!x{`9uz! Oujaۑ^8e2\%m`sL=hkph_j#)y=G׵3,5u?<(#SBWeux'Lsݕj{{ݻR+N껉}.2Zѳ8[Arͯ2\LO.f\:r"g6znma,9V;;\1aB.x{CJ#P\'EZ%Gz5ȷi#{΁.<]c"͇x=i|A]ٝg}_ <?_@>o 7qsMR~lCߏ~#\drt3\z=+Ǿf}MȻwzv"wp;.^MwqBz21~ 5ZGk-ioe^PbO֯Z;k{qkO%vMvy#3*ȅaؓ>h4nrWE!轐œv1U'#O!D=䢀J4,S< 3z9)Nnb /%P!8-7lkj;}񙍃K~ ZC{2 Rv*ɏ`#zz8#n"{iN#ߒ<|% tT 0FB}eR'vŻpst?HwNw鿊3:4KeN}v܍v(o`t5!s?4t|uX݂M3zH?ww3hy pz@Z_2.Gor_ҽD+M<'RiR,E_zvkv?"I+w#SE^&;ok fk y)i} {iXhLjc50 m9cGsYƪvgG Ю, eǰ~Q{( }8B#?E8vLB'>|' #}x~Ow~?0b_Cza=Ll#*_8΅\:6ܖ`W"qz>;&d_X|_C0領mS=hmjwjANj#5;/a/ ށ?w¬$fL!W'%m}T}w>o{]C24okMB}B`%nvHGRcf(Y[0:}m9r\9p1>{_roˋJ^b0=~ܙ!/z=2|ǫ˘n͐LiA7YcUO] ]Z&!m Kf@1j&Oj=4'ŸD⟑ʀDi&:um:/e\Uus$44!@&KBuJOH)KKIH- K3ЙڊZ VDA e)$T:S%ָ)2S2:(;KνggLT4R n<} ߾ۛAS#/Bg)cP]h&qZ31$Y:*?F=?767ԺyG<Nˣͨ׳n&.JX\Pw>bB`.=x7m^> UO1Z]^~gpF!7uңZ[wW'&kY8#dgv_{w9 NeJhz>kma_C:V3j]ݐd5שl;X)M9+l)i4!4ou;Oaѱ+KТׁg#UXN vk@(yUӆ_0"B˓gu"F5 4˱@e0 K}du_|q|`ϻw_Nu.QհB\u} +ܕ8O ܦ9x)c|9) Uw>y:9>;2ٿ3MD/"-|χ5Ĺ)ແ8~wgŬ# g䟝ǠZd8`X{Zh'0m h6+'}H컨@:j4C/hVh+ .j2.D8 &R1S{؟sߡ"4=}8E3b2No&ر oYhI֛;yx |lP VD=s aWXjAaGʨAĵOkWm4.F^UcՊ2z2%E!n7}w~uG)>bIءek$k;4܂n3Mo\koh:#NR*c_Q3;hs'w'!m y jm͘Kw*{Z-6Wp)lZt;kJz$q h_֗6OT1v#BOΡ`$߇Jtldu|dzZ̥l&QiʅgFs;9'W2r+E'V0 Gu.c?K }`;Qn:UٝH/E1u#7䶅vè֯st7|wr&[p 9m( ÿn`lvDdn/@:jߘBB{tr7_a_#ȺT/V4s4۳·ǾײOU1Z4Z-n]>(Ү E;|GXo 4>Ҭ-(} ;g_=jd:>)*]إQ>~RBiϹɟ_NlI6.4mZLkn9Y㘼8S)#Ȼ;U2Y\8N}šNS$9/۩ֹr8va!;]4 tj 8sz̓ӥAr~A4^CBhBϙs6r^G:n C`Oωzx*p[^H#0 : zc`(UX\|띠i"`IF\GyZ46.  Ƅץ^zC )hs6U&¢hڀo=bAW4Z4! ڧNӖPNփ(PPS5 u.<ߏ-yƾgn@wi=n5|N=E \T3ѦDs1q= }S1=;5]yyslG_#J>#qb6W95s//gC80 7e=}\P>!T?H4Cn  VFK(O@ￒ`_@d~-Zvh!^d hvjpI V1z1-A!A/ؔ1@f,ko(W:f#/!瀲+û-gݜBD?Fag8KiJ`cu7 bJBN7eٴkz.},vY(}yy܁%l=AV ]DzWKN:];)lpؼ'- ho= 4rzSگgITm+{=@vvc oxi&쵾p ]n:ZO[ި=1lGH_YdZmleD}}^Q5ƲW۝qMӟ3tTq6JNrT>%iRN}CZ-X/`pyW65}o8*͗F'kQV'qlsz84ֲ\xSA UJv#{6CCr:.5MN:p};%\A!TxZ зByV8M<-3|OPM_){jd$ZO8s~@m |kfMcu}42 r~;!ڳv8k} [UFw-U]?|#Aqy D~ln#O1λe"+DڳWkNp\3ъQ[;N4!"p\P( BP( BP( BP( BP( BP( BP( BP( BP(2QW4Ntʡ0Y`J&D;2@D񕺏Bi2LZ3tOtȩYM Oi=! nAotZq*R*JhA6d( RCqs;B @|X(AJEԄvOQRlH9C6ELEzzlwl)==P=|TmPf6`!PN/o=BhcrOb²붧Mj["br$GN)t#5(+Bme2Br8mrlaS#_($bŇfj?Dz dP%s=J" $V@H(){AV^^ZVɛ;lR=qKc@*H7;RId';T³ք7h($NH=X'!paOro D. ƂuDy]w()jj'ydXW[#` ½'Jy2֝mͻ!;SpЎ&3<>f?dJ{G8x9ɵ"OP'ޞzq4 α.AE#dY%Pz{ɯWUb=-c7.^x0/(qyxO0G ca&~eɂHjo 6w} *.2, .YBa,8\@ ]a4O9#5901ts@-ׅ_% -bF h4zeHGhӶ~r!v͈=*nwX[H=x` x3x3H[QX o]SJKj 0\ endstream endobj 2029 0 obj <> endobj 2032 0 obj <>stream H|yTTG_iEq׮Q#1$QAQBFTDDpW@77P\pA\5Kw5ƣ8fsnսnm_ Hcz`rDŽί`+4|AWZّck .ӣEt*ڟ6 `<>_ 00#&.~܌S\t>1zNx]  ^\Za1;v>v;cp?v^Dlч= $S:Dhmb ?EVHFT0Qa?I|g.;r bc t@Gv;6 Upp8?Q.|?NުT)Eqֺ\Zvjֻ]}|$YoP:wڭ;=zzw`?o ~o 2t~4r萏>f?}2~IN254 O>cfԬsbΛ咥 _sY+WN]6} 7el޲uvܵ;3+{}9<$/(s\ TvkoܬUY5w~g2_[p~СNdWɪ <_-,!U*jWh8N*Sĵ0S;u__n64L)}"M&I%qLLSd[(Py+/rL/=zިOo7 ahc` ] # akE֊NQJ%XV$%YIU6(YaRQʔJlhl 5#s'-εm [XYZ/X /o|o% q*|!@ IbG^!1L\%׉U3iS-//NRH ũRT$KKU-(FqbBm ő1Ibb{_ Pô&[(d*P)~)C1)r޹WzqzZ}}9Ł!֚) (ɶX[>OT{6Qh@CUÍO#K@[OբXgYD`QY~ySsjQMz~)KE%,[eff׮jsu޵skyƬU;66<<lg2{ f/3,L?8FMsb]63LV>a3D|'1˺i6XƟܻ\ȝgxBxS33澱bxE"3Xo.FLӺji2s"ťą?./u<NkU׶9B7mcu}bJּF{^7ϩ&2KkִOvMuN{dV /ʡ\O ÔGT@t1B8"*JntJ&w@=EE Jgy@ɛڡԞ:%*CGk$Lz2J:ݠTAȟH!#URݦj;(NԙPW.KaY*[Zֱl6 mV 9l;v]l7dY,a{>rQYl?;C0c#(;Ǝ1+b$;JiveX);.+cY9®k:n vU*uQmSE$DATD'Q#:Zхfլe4gsU{־{:sTQ$PG  c!Dｚ8@Lb#0cę$8n)BH (w&_=T: UU.˪T]QW5U*WTmZUӾБ:JGnctT7ӱ:N7-t>qDOp#܄r38n-888S85\s'bk`_qA8PqQ8XqNpRp#4N nŭ g |+-,ո:7&܌[p+nt7ϛlw.cznWAWb7;]uo=ZVUmXVUg=XO+l08B xCDBʄb14 b!.Ua[mv`eA"$A2@*4H7ܞ;p!_"w.ï!ZAkhA t70&̇`,ERrG Ɠ _4x <,b,x /c)^x :rx]l|VbVc X)=c>2S%e)@l$cHP$)҄Dd#&l&ce"Cl.[x@>EP$EQ45Ԉb15Ԍb)S WQ%S RKJtʐ2ZQkjCԖQ uN,u2PW u;=Oԃr'}~@]tɵ]vC}4`BCi 4FhuCq=7@3 v{9nO7 1C03܌0#(3ڌ1c7[o[-14x@Dw4T=Mfh&͢e#BlzDC5A> 6# [`+lv.Mscz{SC_2Uk[򇼟A>će7 &$dp-6)pG,R\ybX/6bg\8"R|#~0馍2M+NӢ@K⪸!*q}xTBTNYٙQ>uSw9ZBK"2Cv]e7=|-sd-ʁrhƊ89Q(%|]ȹr\ %r\.Ur\+In.ww_Oâ\UC~nOh%OɳPRVryG>UN+be"UCQbT3*^%dTj2ENWTgMuW*GrU/[Q}U?_ P 5X QC05\P#(5ZQc#l>j&ij:pQ\i:N9N>®Nw'w;Ýxg3ٙpfJBPy"t/ (Tzb,#4ڐqo>o9hgsw/|o~fz^ΟOg9<-_Wyj_ F9i~1̯9cΚs7)2Ŧ\4eSj)3 sӛn#7*uɺLvllmMmخپaGQf2RJ2Xkuf.,.ǽyW-I= Q5Ŕ" th{} UiQԌQ:$Z晪i1}ry{瞯0 lW5;Ҏk/۵v]ǎvnlqNSv8gsyѹ$9J_Q`Wh'sf!ʗ \9ǹ̷eoGd^³;DOaGp+G:J)Aㅕ;cn;| .eZI0mB~s{ /Bns*n[Ǎqnmƺ]L2]nnƻMm3 33m6snMw{$MqSn `({'<)O{*y=< XhSY:,2u,15}]bFVd5`XjkcuYj#¬4fYc֚uwYo6|UC ;˷dUvs f̓MmS)11fffef9&{)#JoHՐ r;PEh3s a~L:hՠ_jO;'LRt(}RuB͖lr.P 9G骚I(:r4OBjg< PSP_F xc*VIo`ixr *9@ b@KHQ pYT';bvz@Ϯ6kɝE%TkL+i 1O9L?7)P질JX^LiD)ZQtihCbI?OU)zMx6?ESS,6&B'ܝ%VLeR_A }t\gV5?'Ґ>5tJ7t π): t67RE ®ߡS¿45<VB;%{"s~ƨ֝PБЙS?ɟCiȇ~P4%J7X:ýyl )o-\UN A-TB͊NVO/ƣ;[ TI֐uQ-e[+9 ^`;uʠV`:[a ̨DN=_"ŕ憖vT g(DS[x?6G:a]q;NFd2x(Dr}C.#BT{Gd\tH|+~FVq2Kr]BWwC(|ehUW5TPZUue[#9nW=iP+ g?M*<.E>gPLT\$ VцSjXO)܍iHlVU9.mW@J1+GV`Q\˓tY^l&Y_(Fm2'N&q*.$ITdQ+yf0q_4>LMQ9}#AjQ%."`w>K]fz$.8*S6]ebLQuO Ls(ןNu?u'T SA`.T^pLdN27 PȠx_P^b7epuPOzV4/ Ì-<;4FSmTN֝D'qIv{m J7 JzwC,TI~Rɏfé;M8|DY?Vfrň8gU3O/Ƌ.6<{>lߞ΄1Ā؋w`,adg;` F Z}M#uLdmվM%}"(7w77݇="`7.߿1k~ꕹwfg&͋Ο;etLh?v#[48N_}{Ն=5J|W, }Qsm63- dvlF.abT4G'N$2fv#atRG@y-u0 i+bHrBs>WOK-HWZ0bE,Q@ wl2L]4 RFZN7ZCG!* rnn,0UU!'^0TR#!Em?*h{q)c go+w#SS\v& 5+he%fK>`q8eN0E$=Jtc;gij$1X,L[\M B ;Jgy۾{+i%v+زw-(>;|'90Λ,Y sʋ ?~sf`r^{O/jqw-bC l0?dO4Ɛ2(E|Tz62^> C!Xa8 yN33f7/v3ޕᳩ)Y "D,!pѦxuq!Q!'P|QHΨA9fD`Y x5ݝ ^Q{]CbVq`Cx3y<2!X(<k@V|4좱C‚yÀbw7Y%"(z%Oj(cT %)%,ßCNWwmvSu nv9Eh  E%W_~*iA?lα;:ӦFJU0(9ܶV7o!Y,˟Gv|<]=OK(Ĩ ǥm jN<}$ձ5+r-ZtSXT~@:Hea2nS_F*F(8-G"X_F$#+ϫV8RVѦ8EڼuM~:1aӕ^l~?B϶PMsa~!#.Ia܅’  t:]^Og֕.ʆU'Vu= kk`e۱݁`Zڍ{%IWkC'EyYă`ER}I寨upatQEkWS}L9%sÀ'࣌Ŭuwsȷ2>I/L -7h|oVz/w7w﫨'q{؎'nSj<֡nHXbDB JY  c@ -[3T!64bhlP6ɾ;|>?&x7ηUwPR~5^*yJߑ`$tܸ|HA&CwLۢwW12'4/27DbAhqdqDҭ/ DI#?k>JCr]dT4ۜCQHONH/ş v]#Zukf:US%l ;w:jRZnb` j5KawERWTz:_όB*/,W}Uy+qYNV@R$Pc-lp _' ; 6ZC[ǃG(LRL;"+&8r'_@x)1L9Vd'}xes<@=8#h]DYWMItLH[kk'|kYBQq B0.YYH)@jZ&5 xl *YZHt/|o9υ>yɓۖ\|aֲW 郻' cXHS\B\$œ2 :p4>$E>)ճ:Fcq(R&'aJIs`\{;X(%32) 6mckmBx\^Z. 84`s ACFyrrWIV yzzX?++3$c|orA}±VZ^}RJv:UDc2C1d@O=bɈƆ,UC&ۘ,w r#L-MwW#¶mų5w|n{-wn8[[6"5loVY/F=z~XJ!EPh8hp`snO)+h\Zƀ!`du+MnS4o y#1_b)nF =[g>O˪ֲ,OY_^4y32 M5~u4S?>)xƕm#;˅BI B!F I+w̰9z 7~^oN7дPMF]Cpzۑ=[Ozfף_&ߺ"fsKCGo 81vă/-@Z| =69 \:.ÌA9j0Z59toFVt0zBQs(!4;j:߹mMfC  Ac"PS2$Pщ @x " f`$`(t%t:PUk-}g].6~{{h`|'" jY﯋,w>oE>Gϰ(|.B'?Z  i))8w{ShO?^ /B\s{ Fz3l9] aDrfZ*K` V3j^IKN2/h12'/748ͨP322ij2.}vCYv"/ͮ(q\OY޵Rb_(:aTΣhwOSoYn|-d'HmCAuTI+3fq]ՏoOKd.^6w\6ZgQAi~id4[4`wom0ڣȵZ^PhyAa/Om+ M0,T*?~3/b$>j2ji'* ,fLScq$*\M ICVN!FXtp{Mh?W?w+_Uަ?%5 »+qb??>cgw"\D5{,话!'_EX^\w1ПG1/<|ɛaMJE+i&9ӳz MhA+jjiv}/x,W l}X̱瑲f:si^v=4hs17*hb)h$FDn|6xOa\rl,%g" b/30#@ ֘00}@~ zh艷;$5c 7D̳b\ޛ= H+BɤC'zh9'oM$tl%Tį@l9a)i( % W!]@*v;0E1~GM{ 5;:~(}F!c5@T򡎞eô+C-@+e' \Z0 sY ,d}9Uey, 9cx<*4y~WR;l]/Aj@u yfaʀ+@;&X* 07%? 6n=L+\NqL/Y57sƒ _>SI ӮA eI;CRf,gI sM>aѶKTM7[ҲER.icb-v}I*ц5zy,+Rp\ڴz6]]PhxK? !S!N'dؿx!("D`50Y*v:D `QzFjq>yګ锺g}!XMlebR.R3\b=K%-J&r! L\6 | M'rn,b4b>ϷU-?SxZT^J[-?Zs|1߬tLӯx:~d>0xx8WP<}sɜ:=3iKfQ}-2^oM:ND}& 1rFuvLc?V1c<;.kkHfg_Ub>e/x w{}#2?텳25Y,`g̽B=7c2u3,v7 69A_imsyvf(N WI*Xe=x(}+b&%?g~^P{%?qi͸y*E̦ohK31\' y 7m [C {HFVޒhHŔzUx;oG{< \w^S:3nbh_;V*k0\i W+Kt}o%"#e晍h[K'r6v'8;Nx=WLث ^='lbɑ!8t mީs y}H!o}O1=duPWv`l2xߤWD8O77xϛ r?eoԠY] /Wiw'*Yagde]#\d$EQh/:>!j{leO! 'Hv_%_`< ,ЧwXH)/s*=M*=%39=e#~&|έ V̻)m{ji[T7q]}HmMK ;w]mqA0+SEƴ4wxswnpfۂGxk3R3zoZk͟I1,g2 E5DjsãN(}[pzWUq{%!$ MpH,аɒP*RR2RKDҌyL I5 48|, x^a 'g5sh3.*<f&%*=C^?NEhcL}}&: } .ahfG'+qn n N:Y@1/r|g1hj'ޮ6 % rB8)7:v |+.;.R.*PA8 }4c D{L$9t";u>C T/w:zxvOqvzu@FLĹ[ v>[Eu",fR&N??6Ta*Q/|@(֡ZPj}lX2vP-4q-UKWX LI@Q< "u__'jQϤxv(th9I#=`Ly%נΈTxA~XWT猢e#8Gi?ZIIc[i>~vB^¹e[d3Jyi{!EV U<"i ۢ'aҹ^9={i%M织UHГs+X-!m&;<i-Ycns)[ITh~Gr!@DɕL|e վQRCu;NcjhxNUv'R?1zvQ~ y ma겵0\7ߝk}BF!ve;/ĻF- ڇ7&^ݯ\28F׈~/.ˠM'ƱsFqSÙ< }u[+}Q9)[O)4k8eFd'ei%WDOY9pJqviTnEŦOT~sblS%-[+M MӦspNb8&T.q{ Wu>᜞3tik0kP~sųQo*oG8Btө.A>s>w:G^(-: VW4?H5 <hJ@(7>)?z'hȁ>sQ((Qh~xMC1u)?PoC;{i7\Mi vh36kϧiV:M@|Ȃi๨>SAĴ%d 8639EM"}B `K~<P]ZnϢ[ SOQ{.Ȣ"94u)Q@LCϪ9tϩ9%aN$wf>I1ax]ĜΘpZ&keֹ xè{u'j//alu9Pg,q&ǫyWmJ0/c-η>yzFzx뼍9Wg9vwaufP56XOC_/B:gLN|W0w;t2ܡ%pGǻW!H죘MUCM +0 Mmou?-|?-O:(M~f[e`UQR>S*~1ؗ1Y_ ZGG7RU ^~fPfaF0+6(m%Ųq Yo+7J"RidkzЉ{"tؓ ΍ wx{0IA@oGGC7 0zYt[˜\kr y1y)^9hb"[HP r؅(^7 5z[(=LEF,.L/Ӳg۠CXaCBS3Jb(f+hjĕUC@Y;Ebu+ƛƺ}չ#9J9ݨ笼Czf_.Q]e=M@H${,HxF %$iD Zf{lnӂ Z2"PER:C[E8`NT{7A`Lq~y}}wq4I_w34cD\'gx2o5>J^JCv0xH"C%bo 0#8c? 0N9'H.` W2Q ϕ0z<19 ȹ)m7tf7n>`s.Y 2RXcC柱~ KXR?S v'5>A{}6Śޅ5 g|s=*]V&|lt^3w`o [ORՊ|^ՅҼ N7. 6oeCq o>-FUNyZ_1j~e~nA $V/ :ބ}ַnEMR/h+=FsK#BMoϫ~Xp#>>+tkNy3FiWG$MΠi{i>H?E=ZF {Tsrd!؊n=!x>N=,xSI*s%d;~Qx!Z Swl&yMc xdm]Aƌ~j l Ǩ./=Eu2ri u 69c5>r9OgosYixuǾD ;O}X/&vfp/p6"2 ;hH7boՎ}y xyiԎqX&m *kh#tīUUJ5X C^m(F~ G|mR"vs/l -j|1O; Y _m^? ګt/"3 K3"\6[(KޫI߄β7- / y06Q3h`ko6,` L*f?uPKM+1 L4r~~)˥bkݓwbm ww =0~˿^/N ]9Y}2xz9.~_Mm)Mbt²\T8tl" /<Φ W(㸐/7!`jV|׃ 0?XrHaElԔB-E?%vZ V/~`|"&փ!LY D bH g>++\ٴܕulѥ,ʼTl2+DD64NOY>}b*AәwN0m ;&KwKG~n܊FC?91V~0~.K??qoiA?7FyɝR;^I =ں -n]C&T`iH-LI#!JTRu > B/U$)icE* *SW>'vR*9{s].}a_1i6¾i}fW]eWx1MΦ߽[ \i@'/bg&#}F\/@1xW vl2 pl,`PZ'Giaz]B8l!`haXwG1"YV V[MXOr؃ czsCS+1{0Ƴ c-R:-K)${9+m?D#qQ#ܪb9 vgŏۃn8"I9AaW٤$lP:ujTk{5AD]ׯY&Iɺ |RaŠZ*û@^'#OuI-Ha|͘%Wz\˞)).B; %nKMəU9Sh M۵M5h̟zLMD8,Nc '\爮m݀1vd(ɂ^%]dF*őrbM><\ge\ۆ2ؐlk stF\1WF5` ȹCJJgYl۱΄> endobj 2033 0 obj <>stream H|yXSW/7BDAEȽ ܸV::8mU::PDAQq]{E\Iю'Lys{fXGtt6ap=aVtB֑*O@ !B#n{Sk, LVykDS\I]Hgq熑C+RO~t$t:IFA-27C̳y />Zi?@/c`bjߡc]ڭ=zS{wA:oa?ǣnj7~ĈH|5)z򔘩H9kvs&͛ H^W/YlVYn6o;vffeڽgy9BnC=vɢSϜ=w._*|7JoV;໻5P ďA*Y5Z' ÅB" YBBL=\&'qxY|(>g閬99qL p-O,P#i4V/-IRdH%\6&K+y,O `4 ] #   *#367z[q1 lhPBQ(JE饄(qBe\IU)YJrD)RN+ LNo 1"LQɦi] eB3'3=bgod`wE=YzG#ёsֹ;e2ƨ AB0_X) rS.-#*qX.>e`zpM@s;b\@qCB}F!RxʼnB@*HKϤ2doNC#4P9t9b&C # c98ŶF}(d*^S)~)}M1)Fpfy92;{K{7jhWM{V@Cv$88(:-@|::ru9:*mB[ԕ]8x~2%ռli55l6fc6&T6װ⦾]knsmsyWG‹TnW0gc#l1"lփ۸Ӵhȓ4Yr\=Ƹbl-0yyㅎNԺYu{膽it}jFz6ްWsꆼ-u|Oy6ӳMC(`c0HJl~F pċO3Va# v~3zS*TT*V%ꢺ.RuE]UTn\Ru:k V!GhO:BG(膺MtSL8\Q͆K"_\W*_2#>?>8sn89xNDNdN`~p=fbao}8`Cq8Ghcq 8_Iܒ8367&-܎0W\0܈p3n GXUX5X +`uXFH|Oe dCY!AAHMLl,ȦqR yl!eAEԀR#ԄR38jN-(\EIL)J-))C&$jE eR[jGYԞ:3ԑ:ѳY&B]7ԍ~>Y&$Dd›µpۤP,KrR5b(r+C8&/oK6&t4]8)NQ$.↨w=Gc~O jx " ,BR Evd}̑+ʡ+D*gȗu"r\$erEVr̗&En;D%ߕ{~yX~$? sWEɾ?ɓ<%BY"KE[Y&@V:YҊQT EQTjZxUJST;^uRU7]eUToGUT5@ T`5D Up5BTh5FjO j|G9vXrN;Nd8N :ݝ wF;Idg3Ù* B塊нЃУPM艱0hC56i9j>6ͿW[ћ^f{s?{y:?ݟer_5Z7xŜ29kΙs s\2Mbk\77Mo*J%2۲vЖ6ٶͶcv6gviGqfLJ+`U:X ֙{:8~λ]$Q"$DxS$DlӡF)#%V)ZEQ3FMjZfk jg73L>=9{& 4̻f]ͮnװ#H;ʮilײkv;Ʈk׳ v#k9Ns9u9oo E璸#{{(}A;Du_['*#1A(_'nsB^疦3ߖeWW{g ϲC=r(Q>͏pVVv:b@apvpN03,;i%=ô uZ7 CO9ϩrkn7ƭs ܆n#v1&˼vun6qLbrP3 7#Hm&inO7vn7Mu=σ/ǞY6̣0K9/fyK9¿ 7[[ɥԞz@1.dj&dG(y6ys ,Fab^R]I&e҃z$G +PRӣPm c*L a"9dPDY]5e7bH͹#` b-t ǒt{<\aEU4"cM0Yf z@$9KŒ<ۈk`w5EAq/WعQ۾Oڨ4A̕Ry΃釐ġq֤{=0Ix$<*7*a!O,M]IKGԒ#AU֧P0@N#:*@4X$944V,A(F<1(Ň.d@ >&YlV e-[p:|){@\O)T(= Z 3McG daM^hO)I.^>4-H~P lepq'HL&YY4MrJSnQCib l-e>? .hN$g[Ma.ƫ@1kxIGp(gj1̛/zBU &y&[ 9W>KvUd܋pסi\T<0Tehvf f !eY.*hRMlOvmم%27U- ?4!WK8Ӟc8XLvQ3)ӨJɠ:aePCꨣicCFNO$,e~yxAHTS9##hCjHA!lW^,a$h* bIrikMZY,y]^-V\7+AȜ8Lzѻ^Op<n{qV9&%tʆ4V\IN[s.Gs܍`rXE_ ?ӂ{hL/iFTơ93ܥ 0e?PytlUHn B:j6/ w,nM&[*PhZo=fUk5Us _xID]pJF{Qek5éwEor&yG7o<̓{K%&|Bx?Hr[bfףK54pGIu"ʮ*캩D TBOТ@$< V,xq=s_6-(o׻}CCmS!p1aPmϲF f/v ڔUMR"8hs|(8ki&mЫm) I.(A9f"W00_{ f_̾ؒ{d0Gy[~OTwD_Ky<~x'O}Q铞rփd2xs ]\=0G(Z| ..[cxX'g- DG 7xBm:#KϞ}уN ]5m\_9^qy\CMm"?r}C-cPi继 $d,PE9Far4 C, 5M~ۧ'#?W)s Q>rZMN_Z6| DRɬ284SEכ%-sG _'~'}&Kg()Լ7A wC1!]t0 !)t& \NF%?D\ >GAA|TEQ"\/У2^M\w޻;}gߝ&\1jU׎ 4LXֈR 1(+--QX)-a@t똠k8 mٚ mUR7iC 5IF=˸lj f7a1$˂c^s+TI(qQ& VwY07*!D@E=0SepXԕ] t2MM&j%WGm[qFq ;I"/~:Lޜ}㳻dx穽ƿdC ʥ;dsRRNbZSGYx8HyHJ&d;2G0j~zNUۖfհ ٲ*lU*M"þD-QF^ T\4=!Zw˦Hây\(z\`5 d&\R3G-\ }eGۏLt0$ȜI,0ʣ,:JQU̠h"Q#4i <9ɑHZ(WTp T;´45sat>lhjGyH|5&~.?2G.eW=?xI߬[|PSV.ׄQ4JQ4xfyzjpF<<9 ߒyu"EZjUޟI@T7|{reI{ZZ$F|zePnԁ`L?k#?'?<={C>|ՋI%(*BEǨȻ)s)=\E'q9-N :rOm@r@r.)Z D'p9 >ftk Q"W).^e//26 AxQ ?FǠp%sM Yâ([UMcsr;vq%I$6$i9e&4Ny/;8!_)r m-69i[&oIJe`{_[vcs3W-o:.BUUv@6VPeb%3Jߋ3[v]sއK+3tT:XRt(ovRnt܇gzA*Iۺ "8*4'z`G8) %]Bہ-h(xHdX8j\n۴߾r{o>T)=J> @`AYQoHq~LZNHV7;Ճ5, '5JEah:"-e,,/;YP,}%)`ŕfγT\m]Ceۜ̔ -3X*(\(75_ a6x Y.oiP ƅɎBGvx3OfW9t2KɣggCa7?ʜOI7Ili1S1 2$\}R͈ЉؾZ+e,BhqoY!Y+{ǽQou?mk\s_ kRpAA\ ,bpZ$֢ytLg2ԕnjG% Rk;5ڿ4utHg:2lj$cHwdSdgD [V}0v #y`tt*xe9ަ i&$,r xMAv"DBSł6,&ږ\`\WJ,0ߥ/<yEy^~-qA ރctmmb$%Rh1Sh@ 4کXCъ(v`5U륉4M }wyUzg>Qé5YѢ&.˝;˿,Ku= X`Oپ};rzZ/ikeqH豕:ƾ1:&yɟDX1GD9]tt}_~!c= DDDE@3(t9Imp%$KIDqRQU'%3NVHř^&C"oЫx jrL0yjzD0;| iy1 5dT䝒eT\ ))'KO.ÂB}j~Y2[hIJU>stEm}ʕP5Kټxɦnl>jJe\k\6 ?Yꪹ kl+y-\OSeUq}흒e^W,e[w{@ .LLM,HT4!G`m .5)ts2gYD._WQb6\ [jZ1K ^(8~dd_0uߌrߊ%u[}O%ILwا^d(YĹ\W?Md6^6ul(Fq?>?</Nt?[lmCZK},TЧݥwЭQR]%1Cm~<=͈}Y2jqwU2[)F+ÆK R^U}6\ xʼnvoV'Y{{E7\^T\*엯 ס:'Cýوe7QSnR/yEW@Fw\ Wd٤ugVN^`@/f+-vVo Ǣp f`>Pxii=V'XoN<7i7ȣx߇q5cv- {B5^<\al٘gy~Yo,0$kL}GnjE;m&KUXہqyc0.UxN> Xd)(ON`3"i)Lؿc~4毁 %/|XT`:*aKU"&oO^T PoL(?P^oNc=褁ч6_0Fs~&^9CےC5@' 7^cǬ/^*?}.Cy{ }0CggN'sB{={,˺ÞY;"$!b,~aI@u\X(ze-_t٥s3 4m MP+fS6}*h ]aP14hgiJoCzksUyK>?gc!D~cˈm\[3[wpkvOiE1o]RqVD.R H=H#3/<"Vq+*a|e'bR.Q]ţg8%Z|MNL2 |僓=97p|11h?V1<]X^Z[-b9>rq?Fߢ/lS׽MLfjq=#6^ 0ͪ'l e@/vԙᐙO\i8+Chx5Xb?q6prOT:Z =>wAys~\TOUꧨxr|1f`dr*[ngPqkEghwo^ĉD/} t@ǖ/l NEo$}r*Nm:vNm)\6 ho瞳 m{)׶eT#~I|Ơ:Oe[!f~&NP~=EyS~de;Q6dnԘeyNWIw߿m廸 Q\ᴯ٦FO$Lvރ!}2ͭfo-0yz-XŌm,lq|UsJ|DĚ3(N똕2q 6=y@62ҝ 7' ry1پ ,YSv*{x z/P2հވF9Zy6^w+F%^qFwFX$<)vQ~bםUJ\+cop8h>{loan8N#c9XCRx߃N-Y?(h(_jcixy܏k.,5D ȅ)>B%27O`ИXZKk7mÞ3mAF+wg 5?T.VZU鸺+%>?7씋Vb+"g6^%Gza+!U(^tH):r7rY Y X942w sGʮ>*t9]ք+eτmU^<ojkyϛnk6Ky^= )GZCq{Z4 mC35e.Ctߦϱ8e>٘*Myhղ~ YK"ő%|կUbuISE\Wڸ¼}&j(:~NΞAF+1w u9wb=lmuiߴ9$rꐐmG2V%W>\F_׏|D2DI.mrtqq~LD~V^gI }wlmQ }o] @0> ( y_ɐ'e~=R8f ͛!s|ݪ>1b_ Y\?pȺz5f'4`N;T~Op';rn'x^mm>frOv[l +7?1n޹3}IKA#w. e-h~Tapu/1!=%fI~*9P 5Qvek iKqe;Q2mj wZ)ϻC%dJP*J:}GW5'FψD𻅶,&MDz啓K6EPwx:FN5a28KuLN4kof!c%qinK Eڄ0FBueR@:g^pο&;|!Sa}uλ_^a h;:znTJk&Z{Z?2Ux99uKLs%zH\`fc5v2~#(ynY)O`ro?FY׃`^ dfΓnGUX|F؟4g\x͇adyBRķpY3x|yAeA=Chr2u5B?n!/m~?g;qhvP՞',req(/;Jmk+ơ7G[>Ljo\ǝ@msIK8O=6 wӍw|)v<՗~g' X( kS;-_™Pmӿ}7훟ľOOlz6b~7OѶԂh [Bzk"Wvqix7?j9K3Jruq!Vo]GyO.C!J=ýlZrO V/| yYzK-gţ9o<,V+`0Mͅ8sm:olV]* 'SMޭrK,ٞ'^9߻KDw,NA6oHEy6H:tdcvnwLJ)9?j1/:̘14gLjm<5_qx_JT>kw5C|G:@dD 7u ꤯W @78Ovlߞ!)o߄v[kz ]v welY͗Y&QM9|VgC7S^a:3kʆ1:zvHu23P* KT^NEY*eu,ahenFw Z`{|.@oOyUؖ{ydHmPG6 ~֩VHv1ٖ=)HOKD>:}d㖺( pUϻ{}/ I$1!Bu4hhzO/\ɹLu#;cb_~dzMł*؂|GUɩl>ȓvR\,FL8'vRZV;:eΓmֱ 4W;kbqY7wS/TY<^xV¦`5XDEeɧ;ՀbaJN55OkWh\ U#J1Y2.n/tVy} ?N9O+Bi]M6!S?pj5h~C3q*d(:Z:A1ɹZi~vL^M&Ň;=Cp_cTBE-zLœ5se4qXx7'L1kX-a*bC2ޙbk[F l>sɑmd5~Gץr xT`ըc`Bۘm?E۷\toc? ]}dЏ!b:Q۝Do~u"Ԇnnⶵ2 1 }z?&Y#GWv[d;;JMRNז텨ASል1EʵxTʱq 1e֥/?2hE3>I>|Ľ[c-T3ENCbB X$z#vbʪkk)dyI#t~ Wǫ"G/눎AG P1.6*"N5.~J3x16^2ڲ%`l"]hi1t_MSC;i3RuH^甪W559'Q%4Y :wS.>pggjTu.KFޝঢ়f\dO~^-D5^Zh|W߮gϜ5[{uP9d/x8gŞNuC ss뵏"(mzEԹ} 9m5{v> G5PaGxO"<qćo~"tĜ4sQS!;E;ȉ{597s2Ny7 j~xtZuC;ps;^~xq.tZC^ if{ݏC u|sszG>9Ao zX q{/>{x`5ʷ*tw;7,c?ޭE Xx\u>_1-و3:r'Е#`Eݭj2@jD<r\__3`ilsyybՉx8x#[m`U ۬É)c2 -|_*@ӴSw  0nr,0 ͳӎA(֋slK@Y8QulJZӀ~Љ{BGLӰuN?7<흠-~=;OyuӤP&v8<`3iTRނ5 68DZo|Kl"FĨui_ 7i{o$Ld93oR!2렿Wn1نZj:J%0/н'2N<ĺߛcպchKJ|+R!3RzQ1Kz&M83XSPm{6ֻi+/Yh^Ax"Й](IgI:a+:ވ8@]8{wNRj}j$Ko=k ʁ <`x1p 쭠nEz'=0ZA-`]XvE!9aE4rmGu+۰ iz6QM&lbgL~GYq K4 Xۂ!4$mZR1R5ܽI\λ bA[:T6Xfp`aLÏZa8:Tޛ@;v3{7}ϧ н~˽kKz(w%N[/_]z7E S0}ěϜ ׸F]>VY#1̝ԏ{倱蝐=($+B>;D^ j3֫:~s}TPNFy}|^})(*q9ǩ_q,+'^nzMl$9By!CMtع{GOոn{{vO޳yϙH7qYL7fxSKjs[zt{6C{\U!`:ƻIC^vBcRG WRclH5z7V[ Hs86MQiJ/Q}_)yUҍ1`O~ O7a[xϩu&dyhi{\֞9f׸~= 'Ybpa{<{bއ6s!&Z¿J#2[P2ބKпfqQơY~n4gO0>߶Sߧ ~Jxʳʽ gM5aH'JQޅ~n!JBuFm}; C{}wrLj7ki5|3%\@Jy.Ÿ Q܊3 )w+s5Eu]臰coF~(ێox6Vİ0O{ä |'MU|-8??9Jo-Xoz~]AvqХ迼W| c-u}{-{3=0ͻ;G58/z+|/pCbbB7#ǣ`=t e _̞y::<Df,kQ.<܏qD#* YlJLh4Fh4Fh4Fh4Fh4Fh4Fh4Fh4Fh41.h!1"z]~܈M_!M2TˆT\y컎i [݄{.cl83d GHptz;Cf?$A~*J]dA6Qb M}P)w . #Dr_P :Q?M) -aXÿvZ)˕kg)v/؍fBCK#ƽjhe|Be i#DNFĺ*s{cjOr"ӡBPȑA5ǬSZEnHW:`{ &UJ/J }%INDՋ[E=hStXhP)KixAF!Jf{4֋I΀jQܭzifNᯬ]h龄%'d0*D -ήtJX)+yyy V{Z#'X4Mh3x/)iZIQ3W.n6ƻb7-vER"zxREڣP0*Q&FE*ޛ Y5%zca+)ҲKZHȊ"eYia+,TRd$!;[`$_@26~RL KPLvxszzZF6]T~źo' wӨJ~ڼ+dɞD,L混uC`"+l:98}|N, [ʦϦٙ>>d CɁ/ry 8 FAm^k:c=T %|ZFY|*NA?(h6*'S`-靖E8j^y\{~ fXMwfel۳Ūn&We嬹YY0ӿN<@/B'x.h/=qIY n.p\qf]| l 氷&<#ch-;+a-#u0 Lv?MjA#`x؛촼P굀u dvIvR9oQ fcFKcFħB330dD|(m T?&B/|$ < = vNP%XA;A3LY/PĎT=CJ* d)v(SDx!fg·pAxmnvqipƳmn|HHK*Q *5]"5j!U+QJ"qut SsUC9Q8rr:Yy};;ީ 4u Dr\~ .@) Z)TAW/UKŔѧh1-wϡŔz4ZLbJG #|}k4>|_,a0Ks+̱<}]jonj]յ]Z.X`]+uק W/>2.2vRPGyRAAv+N|k?N(bnp+% {q~B xn" JQl/*4V}(;kB['yH蹫:pKosy \-yyy :Aaq^i0s|4=MQ&OΝ ֔MPl:95}ቼmF=5b"E8‰Q$xF)'44aͱGluo+Ɗ!>K}$[H̹$ⲝl{| '"UtA4M(,ԑHZ,Ԁn5ODWF5@wc4E, 1_ ffY]`,m' !},cE _]]کw{ǜ&0W%Vqzhzpf\a|57]+_Q0 Aa5uyCffV53Ut[bFJ6 K-O&<)Nj *tWS[R endstream endobj 2027 0 obj <> endobj 2034 0 obj <>stream H|yTSWǿK QPxqZuuu*[w(TV7D w\WDEIZюdnL߽'~o@Z" BF_(~*OqQ50|B0:?<46,!{M@_Sx'.fϋ+w:Fe?z ut= +) "4v7?ERDS#\ZLZtw\DD>K n;r`Ȏ:1vH jhs8Ώ{ԞOc*o"sѴкZrlզO|%YoT;uҵ;{|W>~%轁h!}&N 9=jF̘Y̝ }%I_}4y+WN]v] 7mN߲uvܵ{OFf}:|D=w,N9{pJkKo,U^Uw7[~p~С.%Pɪ!@-,!UʅWbq8U\!īc%eD 9/oeR?_64L)}"&J X3d[(Py'/M^Է{ z~~~>YYР20C+A2t6t50"TzJ)*J7(IJRIU6*J)gbR|<4pcqqv&i)Thrlmk ]9^ֿ_e}=oO92TPUTB",9ŵ^BxvS0qF\/VK&CSN1Ư$ $K#&S$@*I?H/W2dONK/5P949b&#c9Ŵfb;Pô[(4SLS2K98#ќb(m2VLakmmClmUuS^5P|cq$'E~q 5^G g^@{W[Ԗuu7> G;NcԱ$+`;͊vcv]b߰ˬ]a%*ƮRvde+g:uڮvITE.Fl!jEWVn*vc߲\U]WY:뜻QD@I@`0jvl3Ӌ(wtm<gL؎1!  @*ܙL>zS*TT*V%ꢺ.RuE]UTn\Ru:k V!GhO:BG(膺MtSL8\Q͆K"_\W*_2#>?>8sn89xNDNdN`~p=fbao}8`Cq8Ghcq 8_Iܒ8367&-܎0W\0܈p3n GXUX5X +`uXFH|Oe dCY!AAHMLl,ȦqR yl!eAEԀR#ԄR38jN-(\EIL)J-))C&$jE eR[jGYԞ:3ԑ:ѳY&B]7ԍ~>Y&$Dd›µpۤP,KrR5b(r+C8&/oK6&t4]8)NQ$.↨w=Gc~O jx " ,BR Evd}̑+ʡ+D*gȗu"r\$erEVr̗&En;D%ߕ{~yX~$? sWEɾ?ɓ<%BY"KE[Y&@V:YҊQT EQTjZxUJST;^uRU7]eUToGUT5@ T`5D Up5BTh5FjO j|G9vXrN;Nd8N :ݝ wF;Idg3Ù* B塊нЃУPM艱0hC56i9j>6ͿW[ћ^f{s?{y:?ݟer_5Z7xŜ29kΙs s\2Mbk\77Mo*J%2۲vЖ6ٶͶcv6gviGqfLJ+`U:X ֙{:8~λ]$Q"$DxS$DlӡF)#%V)ZEQ3FMjZfk jg73L>=9{& 4̻f]ͮnװ#H;ʮilײkv;Ʈk׳ v#k9Ns9u9oo E璸#{{(}A;Du_['*#1A(_'nsB^疦3ߖeWW{g ϲC=r(Q>͏pVVv:b@apvpN03,;i%=ô uZ7 CO9ϩrkn7ƭs ܆n#v1&˼vun6qLbrP3 7#Hm&inO7vn7Mu=σ/ǞY6̣0K9/fyK9¿ 7[[ɥԞz@1.dj&dG(y6ys ,Fab^R]I&e҃z$G +PRӣPm c*L a"9dPDY]5e7bH͹#` b-t ǒt{<\aEU4"cM0Yf z@$9KŒ<ۈk`w5EAq/WعQ۾Oڨ4A̕Ry΃釐ġq֤{=0Ix$<*7*a!O,M]IKGԒ#AU֧P0@N#:*@4X$944V,A(F<1(Ň.d@ >&YlV e-[p:|){@\O)T(= Z 3McG daM^hO)I.^>4-H~P lepq'HL&YY4MrJSnQCib l-e>? .hN$g[Ma.ƫ@1kxIGp(gj1̛/zBU &y&[ 9W>KvUd܋pסi\T<0Tehvf f !eY.*hRMlOvmم%27U- ?4!WK8Ӟc8XLvQ3)ӨJɠ:aePCꨣicCFNO$,e~yxAHTS9##hCjHA!lW^,a$h* bIrikMZY,y]^-V\7+AȜ8Lzѻ^Op<n{qV9&%tʆ4V\IN[s.Gs܍`rXE_ ?ӂ{hL/iFTơ93ܥ 0e?PytlUHn B:j6/ w,nM&[*PhZo=fUk5Us _xID]pJF{Qek5éwEor&yG7o<̓{K%&|Bx?Hr[bfףK54pGIu"ʮ*캩D TBOТ@$< V,xq=s_6-(o׻}CCmS!p1aPmϲF f/v ڔUMR"8hs|(8ki&mЫm) I.(A9f"W00_{ f_̾ؒ{d0Gy[~OTwD_Ky<~x'O}Q铞rփd2xs ]\=0G(Z| ..[cxX'g- DG 7xBm:#KϞ}уN ]5m\_9^qy\CMm"?r}C-cPi继 $d,PE9Far4 C, 5M~ۧ'#?W)s Q>rZMN_Z6| DRɬ284SEכ%-sG _'~'}&Kg()Լ7A wC1!]t0 !)t& \NF%?D\ >GAA|TEQ"\/У2^M\w޻;}gߝ&\1jU׎ 4LXֈR 1(+--QX)-a@t똠k8 mٚ mUR7iC 5IF=˸lj f7a1$˂c^s+TI(qQ& VwY07*!D@E=0SepXԕ] t2MM&j%WGm[qFq ;I"/~:Lޜ}㳻dx穽ƿdC ʥ;dsRRNbZSGYx8HyHJ&d;2G0j~zNUۖfհ ٲ*lU*M"þD-QF^ T\4=!Zw˦Hây\(z\`5 d&\R3G-\ }eGۏLt0$ȜI,0ʣ,:JQU̠h"Q#4i <9ɑHZ(WTp T;´45sat>lhjGyH|5&~.?2G.eW=?xI߬[|PSV.ׄQ4JQ4xfyzjpF<<9 ߒyu"EZjUޟI@T7|{reI{ZZ$F|zePnԁ`L?k#?'?<={C>|ՋI%(*BEǨȻ)s)=\E'q9-N :rOm@r@r.)Z D'p9 >ftk Q"W).^e//26 AxQ ?FǠp%sM Yâ([UMcsr;vq%I$6$i9e&4Ny/;8!_)r m-69i[&oIJe`{_[vcs3W-o:.BUUv@6VPeb%3Jߋ3[v]sއK+3tT:XRt(ovRnt܇gzA*Iۺ "8*4'z`G8) %]Bہ-h(xHdX8j\n۴߾r{o>T)=J> @`AYQoHq~LZNHV7;Ճ5, '5JEah:"-e,,/;YP,}%)`ŕfγT\m]Ceۜ̔ -3X*(\(75_ a6x Y.oiP ƅɎBGvx3OfW9t2KɣggCa7?ʜOI7Ili1S1 2$\}R͈ЉؾZ+e,BhqoY!Y+{ǽQou?mk\s_ kRpAA\ ,bpZ$֢ytLg2ԕnjG% Rk;5ڿ4utHg:2lj$cHwdSdgD [V}0v #y`tt*xe9ަ i&$,r xMAv"DBSł6,&ږ\`\WJ,0ߥ/<yEy^~-EwE */16^1QG^0Sh@ 4کXCъ(v`5U륉4M }wyzg>UikY٦.)_[%zqlo_-m}iב#ȗ^|=#4WIS"4GtL*|-Uq y:f؈oS4W7MvQ!J[1+5!;5"cjRGōZ~X?h +:JEPM_Rrn:)їi 7JqVV\}q1>NJ9qd:3u ?*ySz=S<#gHyLɅh)/~^,ɯ_ʍFFnuJ܆HyҧZ"܀V}NNx'ݑ#6^[k_&>hj훢jkc}W\4)+5g0g>k_}O*N;c|2zg N2ST'Ŏa-LJ %GUTO:YBUx n<~>52_mثRJb@c/$' KNfb2jd$˨;kVj|dXHL4eX1RdX0BW(b͏1T& CXjŝg5\ tXX[-Kn=y{Ѧoo<&fZɵ%?rn 3-q`{ϫnkzT+sBJBvFn$/3/ݒnC2}ؤX567MB~ƸFRB>Y:LFa,oY:J&K^rK-U]+bG'LS_L]',MLO=p*NrwrM^utbCI^Diz(vIq?)IYQTX`wO~Q%bkε"Z*``nŽ=  0Sr=M VSgSjQ:[&@-*6Jfc+z?CXeA` ďsG~aE#?.?Xο{D\a(rU~˫Kʄ5:_VĹ=H"y1ZnRͭ/yEW@w\JWhFlRzpT3}O 0֏~,QGs6ZP_;Dkз acѿJX;~c1*G cOzI k;i Є&yT}wZ#}0h]h߃ vy.[e h<RH"xg9Xc:+@>6P':i wXuL0$~qixsaL ]9DyJo: e|3a枞GhRmXG"Qj.UE*צoO^4 HHTh{Y}@/JX )[^4Fk4a$kX? 6W-9T cX~b}uzz"`" XswQC[3>8;sx5aSK-^ v Z2`4cmº+8ܔ7N{ IgH3{͹xH9Y/YknsƲe_9S=Dރ eYzhTi9,&}MvLYsF`UTՖ|c>9XL4IA hAYzp=ܣ3,{v%bh.z>]u).uv-8-#rIoGlջAG =$[ǀ*`=S첗brDF~x7ڀ ^UT`(iXKD vU\$,k5r79k@0qD7 xNYh~^,~Fty?#yienA|tX1c$93VH6~sHsL]71{}a`x%xqVc/z|' |aP;EYyTϥr3ḳ%rm~M Ÿw6>M8G_zD;0}"(Du'̹OQ/\r|1fbdr*[ngRqiňgh1wobĉ.D} t@ǖ/lNCo8/x"a4<4Cgz1̈́ڪhQ ysǸ)Kz'}mFlڌCsvg:VGWePcm49bDzb'm2F5AGĺVfB[}WQqwwޛL OCj!A["Zj2(J">Rdq8)>QuhvjKwv!\@Og~;==оWxn }K-U-AKj%[ 6)~*k g_0p-76w3η-zhϳ͝#S-Cݎr#{t Ƽ.+srH-hK-r-2 }652}'igf2״d~? Iin5{k!χɃԳ}l*fmeac*S#%LQG~vZǬ^8=89odcm0 gN |P û_n{0F_6ʳG[587*0f7* %yIۏh짭R\1 ~qD7F=8؛e{ sIv0;lumExFDR[?O~|^sf&ZD.TL)!&*ɗ־y"LwO^"Xid]um2Zѽ8[Ar22L]O4/!f\[=߷,9Z;`;u_ aB!$CJё'fΒ:Ρ)=g@;Rv5Q<ϡ|w&ԕ]){&l2hȗ੠}S\|vwc\?=\blgYPhLQ=ۣ?עYfg/l#m49l.w6L6e}ulj,ThSTGUlchX),~UKz6*5q@VC!tu9wrr7z\gIuU@ι{&~O(Egk36GN͑'Sh<⼐J<(rI6rtv~#/!Jjߨui+ϥsOԏc$?"=MeEfkb~ }l8917gFO GKoJ=)C끼Bx@97߅_h޴u/ ͵VՇ=k2.N4̊ZC{4;!sڡx8ّs{7o+T@s/P}ŸuSJyj뵽{1κ]Z 4sp;J(w&>Ǣ3N9{ k>\&h`r4$3e3 . B}I}!q 1hÐa?TؑC[P8ay8-CyQh^[qU7}8zo89F|P>hkKP^r8&ơ|b<'WnľO㱬KgpyTT7]eՒ}VzXjl>.yKa\߭j^4qnj.Ǚ[n/)6#Gd;wzRI>Vnn[f?u$_J]2&&gIw yeF,Dzס s#eRRLٶpW`xa @l>cRk㙨R;_=V^>I;'':meW'}*h#y,g Iy&ZsՋb+cw4roϚ5h qUG{?3,aǝ YxY;V6)YSHϦKEŮɅRM`\2tJ.R)fiE+/s3SϿ,s=0xEX:~{ʫ¶3l#Cj:ڶ=wNz4Gڌ<϶aHQFGz]&yGж7$#]F=el*8~{{IH"$ |$S"Ç)Sj ȣ̔VJTN&X_I3E(V()R"ZM͹{޽vϞ?Jm6vkW̳ZWw-u"]l%)ilx!4gtuO~ѱ+Т7q J#V{E&abtuq@$/<`Oidᗌ1 kp_wAd&|@ P4˹@e0o]N?}3//_LuQp|BLu} b6 +P2gq}9@tFC{ZlBNezh&k*TQ]>#?ҜONd@tп֟:g1b9j'ޡym.}tFo]ڡ_{E˔ͺ~z-9óA9CmzAL#XM*e;ߤv% &R9S瘸8%"HyY3,lŬ* gb NE#l"xZk) szz' q6L"*R/O>E l߁u[ 5iRkPG-jc).q@"nƻ|p=Ifꏑ,]C]jI>Ss^c2Z5f׵Kl&Sy;.KˠFs |m)ݾ ຤{Yl買t'c߅~L5 ]׉$*d||#6wsm4QVؽ4DT-19"V"glvLl/D :u GlQ.WݯǣLĦRW8GWq/.}9A+N*Y#Jk9-uM jW"s,UV][CLL)$k$K.c [gȿ:^9:~YGt >BNpqviTmYOuTqv1S:Aċі-gBNy{jjqNOiF;TRA|y'>a*R(X4ֹ28wa#>;S4ctY2 8?4$~\j9 mB#]v=~f޻W!{0lj>+tK;X}@n+IZjs{_BQ0*Pf,b.Wq> }0~p]b?^1h"Cn)}]%7*g\ Ivh3?~^@QӠ+dk1SsQA~ci˨ރgAyl81tE >b#~{ >܄~Cq#̧=Q qf)R@NC/9i!tFvbNnǼQ'=7߁#ӝvsszZH3~wm` xO^|sdP>RM jާ|ojnE,c-}1?=~x뼕9WU缞n'}f@m=?n-br<䪓ϝ1T=whF ?d(nU{!R#0:7 CHf;@ ENǃ{vosZfuN4(O@ů781ig-=['GW7ꜿSU^q  folv @Ѵ^d[ʲƉcdS" z N:*gžs!/}imChq~ͫ&}2q MpH?ЄǨ8IRvpr\1y&_{xW\b 8i5#FըK`?:eYםHkS}x3%(hg")5I}ҐgA]5 M(=v6ĕRӑW(YՇ\y>v E!֭ EC[R[ ҋge]j֣d6Ao™Q(ǚ:l +7vG5&O[yF+p=7 jŻIdB?FOR>#Nb} ō] qF o`cs2 |(WKW;`'^} \oVË_`oEu(B0584! jk2h|׼>/ G͡4 c,rQsh(|=[ކ=^HճqlljO7gC8gU?6{}նhHJ{uFJtjS8XX\q$6ળ%e9cYHL|~0.qqɒ.y~}|OP%{{+֖ (w %N[/KqMCjr?B_63*5Qϵ~:e?oL:s^9`=zdz> two󗈷"ޓ}eM^w=A#Um̠6c#7w:Oun$ПϞ9qZsdzrb!hZkׁ^̆M -0]:Lww T}w ل=!tw%tif17TkA?WMGgfo3 Z rػ+nn$_%ZW yŪ|gf'?ކ'0gvmw:Zz ߶Sߧ ~JxʳʽgM5aH'JQޅ~n!JBuFm};_'C{}wrLj7kwwCvc]{Qf<ȄnznǙrչ:.ޱ7?c@vm7HA\bX=}aF cR*VGÎ?S_77do' 8%_+x>>f=HC]=cs횿Qb^^w_Ogہ+v O߇Q2U/fϼ˝,IS_C"WYaZ5{(~Ǹ_&ʏ,^6%h4Fh4Fh4Fh4Fh4Fh4Fh4Fh4Fh4QO yi=J.vEnĉ&ѯr@*Ca\*N<G4?nB=T_@I16K_ELM2sW8Mvv ?UR@k. )N1>JKBaU9/iYJ?0J_X;R-Zz 펵`va3B!! %WR5X U>a!юnlb]H15'9Տ Pc!vԠcNP"7+cu*jǾ2$G'W-U¢)G:Bx4VVR%ƿ~4f P%=EP$g@X(}V4gWVՈ.K4ct_wœx2c"HgW:%| Wz=i+VEYE4 P<їu4_Y-ʤ+DBP7R]1QNɖZ")NG<)"H(N(G"M,`iُe-by$dR|,a[l[P2Tmt0MU4֭X<-SBd0l"qq\^/+Zѷ/}#<_FןT]|&L$&g7}-\gө|s2fo6T6w7|6ΔY$3߷h*(O| T(0 jH"\փ=`&*W8d/2 SQw*ɼF 8,FŴ' 0U9xG,řUJ h0TtuUV6ޝeݙ-Vu{6.+gʂRx:Y] MvGy!N"^0tkp⌻0|fT@>7v6=4)?h`h]<;O99k Q`s ,MfoQ|3RPf|03 _3%>R5Y7% fDo{\4zM Lh'Ie@5p*"r fg|"vb|VUvHW K!ÙR&"P 酜|7Э>;F0v>@-X ddjb8𼵛]'$v\\x[4!d*!JTrBJMHZHJRH*B];($H \zic9PN7N(j*u7}oggw 4u Dr\~ .@) Z)TAW/UKŔѧh1-wϡŔz4ZLbJG #|}k4>|_,a0Ks+̱yesގkک ]FVy΃uc`i``Z^LX` V 6)4${" PR5IJK~5̰u}:O6ɯ(^Ae\Fe줌QGRV"~ԝ((Q>DyRçE gSOM:aP_+"BDo -pȳ(? JX&ܲROzZO|IpIXd[YKp+%u&_/I؋+b=DvYUb3IMWZC]^(JgZ? NGB]USW^z{Scj3XCy7p5OG z3)e: \VkL4l0zО#GwŬ8,bDb,nR@jI$H^Iݩ<5<5xDv@`jreOFȌ cߟ&)s,@ h `dSvqʨ28vpD-|:Pa vp0B/\lfIBMBo[ɪ֞ vKʾ˖znlIv+3cJ.OO?㼘y^`b-m8g~qNaOz 94Yds֛,Ʊ9E9vSd)GS:M9˩|J`)aNhz2ΣLڟ;)E)N,urjyی {:j(DnpQHrl1RBO' sih;X cul묛5"g!6Vgc C|,—H(9sqIe;1SMNDBͫri-QX#ّd!|Xj(44j(hh3YJct̲Z+WXOB2vX8<-"z'%}S:9=M"`>J { ,am 0̸;^kn"V]Q0 Aa5u®yCffV53Ut[bFJ6 K-O&<)Nj *tWS[uKR7 endstream endobj 2025 0 obj [2035 0 R] endobj 2026 0 obj <>stream H\ˊ0>ExILZ- әzc .|K&𑜓#',cv/4Ӎqۚؕn5]==2A/8Q_vnsVf:lC7*.k^POzbsPTꉅlS6n捫;9baꡡT5J("rͿ}(wex$$_H =H tF {A3($ѓD2d2mA9RK:FF 88(88(88(88(HZ B2'}nsr껵nhiYe3檖/`c endstream endobj 2035 0 obj <> endobj 2036 0 obj <> endobj 2037 0 obj <> endobj 2038 0 obj <>stream Hj` rh@9 endstream endobj 2039 0 obj <>stream H\U xW{&dhǐ-I"mf:CW(/'+ 5)OW+U Wǁ[f 9ΑE 32iFL:i"-fZJTO{-C,^L1O<-j6tFS d/'dY ٫r#ayIT2DmVnZ­υ ;;{!@y ] mBO.xf{o;s٨xFf:ͦJb$WRjg>ss1XLO &(>?J eWO+Er4Go^a2UzXƨjڮ+4%RjYei5:c-n~|OGֈ%(zkUbeᦊeI(Š{,]^;slYs%p"al=9PSBU_U(E5[N,8R4rJZ YyE{/S"W"h +0G|k\k*RX$UW+t?BQoZBYg!c!ZT(.߱-T7\q,*T˱HsT IЇm-e󼌻4iGq%3y'3g"{_}<4ך~;V)u0VDR K4mEIs]V kAg9\sJ B*RP?`-7qOZ`ʊҹsfgyg&O5*udʯG 6t_&%8B|\"OoG/GztDGuڥsGF Z4%!pFPck7<l 21twd*K?{%xЍtDSr\̯KwƵ6>G0oK rN#)Ngu ai4ohB<BØ cΈrT4PT 1"9A $2ltHz`>NO1!Ln$61Àc>Mimf Kam3 zCIڦ /ry )vӍgy;V?x]%zp֍r\ڃ>n^ ٚ)pT&`$u8;ٺ1vrlG͋9ua7Fvwx{4t?wcRO:tlCd6M<ȍ˽,=rbmۺ{%JIIN88)ivĒl8sDlNk`AaMǰ )g8-uWc0C+(6` 塝s))6 s{CAzEH)`!KJ)XgaF^s#eGD>ڻBZ5tk`c+g կ X'RywM œBG8} 㢪C#9{ҟJ_,2[=UikK5mQ֔<7jS2/P/Ϲbնm|y~ȟ-ǜr#-/϶d 6Z h1-PgZH77ċ*9cZm)?hśgf0As+= `8\ӳ#mA7x2]L.׫e5ׂԟj[nÃ=SvzuUYaO5w :O{ 8 KQ ^ݗMpM#e`,Aˣ1rfkj65[\Q_ȵl|Ԯ}dsrSHbR gpQybGIc>O;,VV/A>kmh QQJ!\?5 4` ZC6 #Z*QrZ |NrG!K[&UD^ŃQm#̳!C857&W̢œT &mhRV GS4\vkP3 +Bч(vM]j)za77Dfwn?ѻ4BkߩsƙzLF@:l"#p`גlƉ{-s8v4CLVJ?k *MJxp:ԤhJoc%&`,|ɦjlXۃqpw9ΛЋ~vT3r''PآǭNe[/BOA5d1g6h)%8mlqnz1!:2Ut8epqCqlhs x[ċ݂pyvЛvH٠<8Xh*Ke2ps`` f*2k|4 HWQq_7kpoȽK;T K˞ςO'g^ JCkXEӍc÷GS9ap^Kkw3n2?yZM#&G {춵")!, %t?i7O_R7O>&#DMX{l уkMH߅U HY\!OC3Q0ˑFBp1rY~WxWitu튼FPHp-`9/V z%9|>GKN[${IJ:[@D sz\_}0:Ba1fԁÇP 02wxy{?{ONO>x_xka^Yx|R=W+&m'ð[Paj`%GyB +8)5 ,3'Ƣ 6ü?"$Q,ĕ@P&F#LC8!B޿XnL$=' s'ښgk ȪiB^1Z-/://98Wᄳ/I0F݈eR8 4&QL7p'a$*+XQ;"Fen űlnSG¡fCX\41xEy_RW}t;V ^e&,VOFƤ[vfx'p(X hO$(cd9TrdUv_D$$9+RtKyG* ;Fee4qJ^`73/TXc]( U! xĐnP7JvXl:P;7KN iNu}߼_ߎMɻT턛oR9aϳ٬MnR+$ZXI(7HT.֝E=@rܞ?OJRl|EeTWypowVVl&-cK k 6; 7M3h:)N#e =Ll2-LK2d:5RxrY}շ{z>)՞3T-S違#= jns鱹.<;aA鷀BjQ?F3-=)+ TscEr1>J8eȲct1"]dcx4ZqyFD|p17t:H[RYer+sjxq2(rN+®$Ă%gy҉دLnge8ϥ2uh:NZ$Nu.SFԭa: >L$72SE?4SwI} Nb'LrV,8`MS vu6јuf&ĩ!flM$vMj$3n7.lTuW?$jS8ke&xKѼ0oO]?xz*.ږ+;{$Nʟ֋>Y ƪ,w:5~23_1@-٤{ȡU50ϊ(DP -%AP d/_ Sy3L2OUl0}\o N(;_ޜq+2Ǿ;.Ư0~~1m@؁0r ̨ԁ0Le]mN6OF rVl{ rJ[X .56(F27vwgY%M[TV5܇Q ą d0C"2I8ŨҰOk&4,lhm)ѺO"D2*Au|v*"D#0^,Ź,ǒMoR;x/BLs*/oP!fPpde|,բY,\Kv_˚l,v$CONR %U ؑT0bn ep1=eICxY$p؄PҺL$`Z,a_؅eۏA9NvKIuDzCᅀHۻjSf}T:z׹eQ ;aeXݪ NMa_$C66aH4={+] ;(0Լ(TԚSfˏ/Pw>:jSGb7o2(}|?|t'1P?%qѓQ&+M ]CQGZ u;z^74!amGr~;xl7Yv'L3׆Vrk~x<25Cj6R(HbK \*J![X..A/?:CR;9KܴM}zLR)E)ʗOH+U\< OiE`;\[+L t E4#~b uYJ& @dUK6ʑkI1>uGQ{]n{K2=K9HPDi!)b cgRH"@GS vjY&@ ҔatXˌj,鵣N8^{>>~uJ<<HD s 8>Uea.Re_'P]آ3_iop{W?Ѯ'Z^:oOk]Ƽpa[_zDEmFIUuR/_~N&o~UT,q,@+"UNMt*CD *ڽju=yZ=:͝ϫj7d)6wK;^ɝ6*~|@< M|NzGm-;a9dd誥@8" E¡\O]Bcx `\,@iXUMH ȚȩD@$ Q&e+ˌ( C8hYFr)䄨 lC6m"crHmG\g@)_ ZEmxR>Viy< WF!VY}nXܷUm7/ZP}?rMU?uJGqX,f=oh|1񁥍dw ,hot >=Fd圵ܺXJdg &Y2!I b{$F:9֬Pj{Tȡ,T2P>hv,k7[8:j)9]tZ+3dOgUkv5iޜs#>DO[v7מ?_ [_Y'LǺ>~D?5^yu|SEG|ix#mvGe>P-AC` hcb4H~"k`qa3"P(Lc>=)a-քc8FVƩܢJ2N!!q*iipJx6(wQ>2l?L@nƩk k'xjRf![Gą;FD4\ 3JA$9~_EBlnnқ=so,jzN|[Mu.<:x5Uv?#/c#--ͥ q3}DwMAvdi[1}sA׸abN& l8 ^ t QV b|VW %?Śl4c|pLz,SQWkSP eܼ\՜#uzAvK,.лAܵCNc a1x(A~욣ۧ/؎GYF@5:VzZ KuzɎ:v-C)*$&y{ؾ}%>'뜇7LrI  BTcuqikʺ, nudJـ1$Ick5iLU؆J[ڬ։<iw~VVY:gjԢUgo.&gn2&OqskHΝdAThk˕1px s?2}lkӆ rp#Ÿ&vmt5W9;;[ :5zW%QRQ11' i1ݺt s-,؁)Qܓt .TР/:ns씎#e:Cim7ԧڗJ[^?,jqQˋ Z1\ bWG ",`u[jm^7aA ؈3J3J776ڃq L^im<0 nOjxꥇ$_? :4F_{W&ݷfűݻvw!Lپq jRI`NpM,'EN^l(cHSi 20c[KI3kSq: ڨ ka-(Ju$]G{gQ*HtU>4٥;LE$6566נ&mF+^gr`RjbPWZ($Pef4Ն,Ɖ[Ta;~09ؾOW/'&.צWM!~Rk8qYnY=?n_S/ {Wwc̎`9=l2WK;< YԯWadp(iUJO—'^޹jM60P3wi|F͟_O OM!9(q2l:Bt4(D p6k;Yƒ%4phʓRaB >(HuPPmkss.'I~`z}MB>5M>::L(?w:8qj/j}]rJz]"9`1|w~W~(J^ #y="l%Ŧ PWܠnlnnEяbo~aE"Nf '2/vL c I-SK.#[쮋F9{-z!WHD¶aUsD%Z*QO 64sWGO5O[< L=gHUr#xd] O{d9KyRzdHzȬ.stBڀŅɅb@;$n/9Eʄپ 61awk3Fq&jQQ=`zs\^pEXuF!Wn(A٤tyEDlqB$hC%j'Hwt˩ORr_%fl I _]3r&Ձa#N } wT"d4N!45s0ze`$ HLAy돩* e @*a+jȇ6U+kм,+ڨT(C"DI.s|7/?56 ;3wfݝuj;CWŮG-E&: UPy@C[@8Z% ҂@qI D*X)ReG<*׊{9gfۆb{};"'"`1/_Kԛ0(܇u^VR3Z%#_nqgpJ(`KMسz?~fvT\Lg?l~f13XLW vQ5 z=+{d7MB N_ܥGYF<8:#Y?n5Y183Z c0r&+`j/;mEUN% 9ɋ90 ^73iIb`،PjG,xSIm U+ 3'oVAW9Ol8{ȣ[׏QH 0cعBk̤G*Oh":k:+MitߒO YTɔOx )+#yVÞ ^: D PcE>Y'򐏝& ǎ0dS̊+h Y0te`E_L ] h_ ]02{et]q?`Lۦh0̕Ũ$auz4+꺖,z&'0Κ.z8=j*j^4 |ϗA-'LG:7C4Ng pgN8dw܋<% gF'RLecM9Dn2Y]KI;sM!2$=MI%x#&!ɴ/7-ah5+W&^ nn9vOy?qw=O'zK mEd躷 ׾ol?/y/k2Jbփ2{eqϩI`/i}ǘv}:K32M_=6眷R.&* r+!-r)e/9*^@3L*]A;hpNذai 6I,ncJ{=9,e7{w{Rr;HvYJzip3p2}_ӱcyf ⠕j&m$Yq{DØ^< 7&-Y-OpY7}]&eYV 0>2$UT~g1*1n(rg0gLrd< s?ԩ#R:Ik \L t"8)@ps@Iz;*s,≄MS>9K׹.e!.9_fhn)}YT69&3UVwPC]*fU\!OI#+rehGgݿIfd=] 2C1Oq7!?dsb}6pgiv0 k>$kp;p}oʊo]m8bfCgDXb 1?e"틜|D& y^n~(r9rSCLc-T(t~4;:qdq֘`()p;Mܠb4Xv//k"}emn!G~ZOF1Nc93Q8ʩǎ5ЯQOKlwܾ6?^x=|:<ʥvQo, o˳6[;d½B<ѻΙoG,3w!r͉:YsQTQ/q<)Am^$k"+݇w&N4X#dKwmg/[]2^E.Ib7GlK<سEԆ,ϖ8&?ڜ,_lcW0n6TEkA~%3j˼rΰbl[/_VX'Or_&մU{I]C|I㶰P`{nqw?μ!G-ƷV4y~vl%#4X]#tv氫B}9kSe1e t\[ji?WA#<#YXFS?;R2xyb}.P8e2m`=u- ϑwk@DШ's]Ш  J>"Yn_b\LOd+:ol91 i Q9Ӄ6=x{\kg,LGdV*LA\/S|{lvRݠ:a9e&Q8Cu@61h_;T*@r=WwC{t?ѽƚ2 ΁'ˆ}6(O7^h';o&z`7SQG6S&"Ē3CFnzm߀_i978fl $7/5W">vƷԃ ~^OOօȏ=ǐ _Qh=,w`^C\4G w^ȩs!uozD}Ԕ=ZVg[?loe]ѧ֯Z;k g)Bۭ^aHR z!紓$db'ymQ ccRB6+\{><>(v[jba jpmيx.*:ݗ/+Gy>BHx]ڡD;,HEЎu0q?nP挮Oq`XC?9*XxxIry1hDwoH~!;ה'A; x 99X!nV݉ﷀ7{MASȷ!E43%M2=YAV!g×%5a7[,7C g9"Y!ZW(90GHc)kl(c?Nqo=f,e[euhjK@a+0p0.mЮ@er`t P6cHnq#I9AР[̡q|3Q s۷m/{=?h@Fv]iQmny;_N ?rL!B gl؟sP͡2EKokO1~b6`FVL--41~E"Ws3 5wcZM@,*Qs#_+)7ET ~#|]])5֊O(6)ʄ"LJ.#حHQz&̻MqZ0# :~3q:2)lA>p䇻GrƑ*0 o8R;8w3A?Gu.n1-wlަa7l,N_/B֚ov<9e` AE;SI~d=u_\7~\0}^}#2S}=;0`=o/hG }[N9ݰwg<@Xϋik?Ne!V=hwo,r3C^0U~El"h>&~r4^Ja)5mf!6}c&©u~e1o , @W1qZO1EΣ1ΓTm%| ش4:c4Ⱦ@ޡrٷ}e{gn25f:̶ǠT$3㧽lȹ]BCth!=똇 ZD}Bz?:*tGE3(÷|^brv@JXmwA]먄pW}$31cZwTd@wtfL^6E;T>E}XTF})[1Z 7GO6w|9=0qL]/ $CTặiʳ?>ҨwȠdmB׫g*wgoBz]觡>}uA۠QVi!=ƾg^&tu J&X}|ukl{ Jiw$zOҕ4{Է&?+ɺOV cYb7 ТqH5#C]"0W |jx!"D^Uۭ /HNiyi}u9v T]1l_G]0 ĘM_tܮyw7dp'ߺL(j?l_u=iC={_ $t۔1i e{7e j}yC:9m^1L}[jȾq7?QmG'+qnrn N:(y"֛%g%|§ g5@_ Zޫy ݗ ޶ qR1zu2Mo{gGn'P/V9lDh+ .j2.bo.uv &Rt1˟P_}ÏZ(Po^t a o5-pQKww0s`lT~ F-X`a)j(4qr-ƥhϪ=RP"|=5CPnKIo/"kaGBGLBh]Cn~w%w!}:HqJ;11Lq4ܹ}!4ֹN;i[8Q^.oUZ-Lh/ƒ;_)CJZM6TLS-jm!]S:כLkq#@"n=|OW1v @K~CűZC%|CT;\ϖт1[w-ƒ'Yoޯߥrxݝx˄mLRst}7qQ{>Ce(0)N!U>Hƻnކ\7u3 Ɯ$S:g -qSdA\ivc#`+oG^(zn?7h h߸-8{= f?cuhuȁg_hwR1gW¾&Ueb(o[S4ں}PEADo0VV}[ÌO S5s׈,yJ;^aAY.(܅W5mOŦO*_?v1,{KF[6q M&Ss4`8&9WE4߹+5HqR BwBñ tdiTu][C88}?w @Bؓ Ҳ)WH)LQ" .ZP* "-S0PEj2Vh w}68sy|,ܧO~\.kuhΠ}JL~Q}fM7nwo;9N$pO\2/s>_Oq#!4 휽^1#r m/Sv a2q$Ϸ|$3` IYayZGlyn(}+ϬGٮ77_Bfoa} 5 ]chߴAX4r#Zy?$Q/w#TY<\=֛˨ \D: K9|_۷X3r&0EȚC0b>79jb>.WSnR%G,G|߱OEź^> !nXz>o5Qd.㑹 9 P@D[GaDן{rʺ o3p9fl}~Pv|P|y~ʇ#jo˸^ӹnf*2r?Ya) UgLhSUﻬ>fԒU<+O]){FyAU*ƃ.DLzvQN~\S1!5! gVkw[l]m̢ݤ%1xmƯ1$ Iq-(5ֻӄ3(3׳ozt2!HO.˯H'5;ݛ{eE{Dc4p֋jvԉ'ɴ-;^E}ލr bKc~ݦIz =m=mUw IԄu &Ѧ&{$Kٓs %$"6ƴ)r.Y~jmyi#IE[g4ٯ< N2|<S6!12rRS Jw>7^ƕRxT#Q凒YrG}d/aUFkڣQMֽMܳՌ<~NKýf}>q:/U20G#:mE1? V/azC1[;8u}o7 ƓBƞ2Z?sɧ #q<S^Pg"=r%7v"h^Ǿ6y &3'iۄ!(N@~(6On4dZ'?X̜6d-C=e%SkGyjE$xct7GP;oVh`}';Z0|1ωk0\1er%㈱}>?eܳwjQ·)_ڳ`w/ ϩp$o0Q㷱0aYVN&pʹ>߮S3߽6Vb5}N!T6ObEǦ; YN |i y!@o|B5s&'(_1 Fh4Fh4Fh4Fh4Fh4Fh4Fh4F'ţ@ |} 6@I`4@3Ql"|/[,˛r9. X 3<o7{k;tI(/~7%Β`;$[ Аe~!&&섈I+ӐƤäp^0e֬hD>~X'wMJ4is9{v[fdlm`al@8&4%ĀGd#'IRzv-dd4 $q4Nz;c$-{ Ȩdu7A&閳b;'1879c$;;Xje} K_5zC3$X7u2RAo^G=:>⟙ϐ'm""aY'Q)#!=)+*+s=v#'Q7*k"aXST:*%/dt˥? _r ݇!FQdwtga8QyDn苜iS36hbdd"%Fx0=cic #;1h7|21>㉣$'Sb 7mP'Oh$wObxwGbXg(mx,Š$(O'Sjhl"2hH1ݽ|o,b6 n4Q#y/H*kDp,n8<L}דJcp8Ng|rB!߇L>L2c~ؽϙSftA^4VE*:5βWhY\~EHl|ڜAZ@V_Q8^Rrpld@<E`($"JZ\s7(0v^.,9@AeXt$0%Ox)`HFJf^f=-̱_vndwX^ӶiɻzC}^{jЫWJ)6Yē(%%)'xfjtԼb#Ta rWjX-هpfu*O.G{GN%QsV` ˀ-{ۤh)`XmH7{K|nI)V MlMH &h5oIX0ڂQ`xJYF(W'REvJU ǯӲ/3ܧ]67H$~nALYp g ]L]6-X~~MP߱H:{U߲_Izjy5|q1nh7t#_x\ͣvd# t$`gʊjLr,: @ꟑ$pL pGaAL)s?FWsп}XB~z,!1XB` w‚Ȳf=By&P TiU 66!mĪC|45PSӠ|;y>jR3@t+Ja+uʩH͗NZjP@UZ7K!LPtЏ*QJJ<!9 īu^fZn \eX 6\L \pXr*$>) hS2`,$ )^ w6VV*nsw**uyi7eͤw<%Β,-`;&ţ=[Гm<,\KH6<z+I:~%h0kj1jVU@2S/kY?ҬzF{1犞PΩ[%I[BjQ2`\Z~H|HcYU=ȳ1ZR:$QV{yEY:ws9_uJpwqznj痜Nis2'q>u-2BڤfBG J/+]@\Aǁ,]ءm4"]m#דiue7MT޾, Ϯ9Big gB!R^zճd?E)H_}vE[\ׁ>kˋ/V2~ir2?89zKPߜ~#P+KJx8:$ωyZF(HI t}Fr&92~/gZ)5ɢ,)) WQ%EI \Iw9jStSm>i E;#p$9t$$>stream H\ˊ0Oe(^c ".869v1J ~bҁ>CNX^N,|hbMk[EJqtWulji YlAf5ꫬ,CE(RuG,ev4o\ߎy xzMP+QG)X~vOykk't#'"C$=BHBWy%{8 KS$pd 8#D2d2:A; !@jyb= Ѓ@z!C=dA RgH-:C2K|rnsVZ7&~4|,zNU-o+- endstream endobj 2040 0 obj <> endobj 2041 0 obj <> endobj 2042 0 obj <> endobj 2043 0 obj <>stream Hj` ch@7 endstream endobj 2044 0 obj <>stream H\U T{AWLQ\Ƶ gesI0QL1V1ƸUhjc֦ F$VԘjiiL;cs<A&?YOr~z~,es*J X}(x`~] @U~&f6.61MW>-o6o彫]Ua,K= r=lsS|OW! AZ^FO0Gt DEO]$#yG;ϤDk'LTut׎!Mۃ(z/6_A*Aw_F"XͨEd1i| NN4T,1H,G<ǯ(:h. (C=oM؍&y3klf; `ZiS#T|| Q+ EOϰ h"{p"iLa-L|z^ q®0f`Uuq'pB6M Qï8w4#1J0oG gAr-TKВgO[brJ3Ǣ#rm|d4rE?Q.vb Qxoe)P"w%#g$5CaN )bxU\>u樟B)nQWF4jeFt1"G7WVj,SZVj,yo jdr=`_ -8Ԋ+QudNSh 2ZGBп?t["]frYl-Lg?ŏ2Br%e9{U#72M(qNжhk{ڻZ%B>no91 0w3pp9 elԟh"#3JUTK}?D&&z<@ c$GTbhUN/ bEc7yE~/0*XRUULHP5mvJl)4Ze}šdlʹX7XZ? rqu#=%B:*JgP TֈAѪ,#H@a?HN(%b=mpœ {slYs%Ppb)\dU; !\'T܎Co:Π<r(~&**J_ U#觕Y[ӟEnqtéI-@ZnX}8$UE^ ,Y*\AKew9O<ӎrw90FI$WD)91\kq0 O*G[/O"џ!4Y"c`xy+w[5crKYB3dFkϟUZ~Z-vףEEFޭkΝ:wZ4%!HsFP1{ 1tWd2K?{%> tC7Sz#Mc~]#_7nv>yHonKwiO{}NW* NqxPlsF"uAaas:(GjCu əyh=?>ΠَYcN"Hi7cXR k8 ^N6v,Wlh=#ϐ.l7ՈxjkJ^̓,[F7{: l<٤$ս<gUc^_ScZlْK9u_NnvS{օ×wQz7qucаv]2{!Nu"@SEɼD^vY%kMs3(6%-L+fZo\mvKx秌٢~)7rBlKmŀ\ EyDQqixCzas>oЖRȫVyf4C[-)N5?=8x'Ŕ>XixZ?[s-H(*@EQk6JLHQU6_Xxd4 0(EPhtz&_(WЛţr3&>")Q@XS:o:`C_X !%add2S~ 6|8Cap\"s}H w! DY@i1GmW.FcM8| r`,s珗ϽW?Ξȏ䃧ōV핅Wyp'sr`2Ѷxr}> +MiEH(&]r'Rcx^1sb,`3̫sk/bJB\ DebD1$9S!~j*$=lNc0‌}&sBr;0aCCѫe1^:N8!8 cX`ڍXF.%_s (Bc2E$8zwV I%#jTPF/a0%4!j;LW?@*qe<LGc[QQfo-dhLnnow , l 0QFPQOR2&IXLy*'I\ew`/ {JD+L"Iwd*°cT]AE ps1a\ zJU>օPM uQn6ܡsynTׯ ͫ?+ON(GPV<4* 7&eBB{?Jbݩ\t ;0{=dyD.hɶ WTW{lS?k_||m{m_N8$vW ki0XIH f]˴In֩c M史 !=By%7Stgqpɲtq"]dc+6HD,ѐI8ZqyFQXBp1?Ut&HrYer+sxQ2*qN2*$% g{3לLd"e8e uh:AZ"Iu˩PFԭa: >l"7%?SZwq}c'LrV(`-K1vu6ј ]7clN36̦d &5Mo VtVV$Ws:QY䫟gRRu-kzeu Ty]ȥ_hvUZv`7#'׮w.7WfO1'sCe:b80yA7sT;i>0I0QvV`6] ¶ 3V ̀3C( "?[;Vc|Pvvᇑ9_ŭHpNp>z Fsȼ5ocTFG`ج#[DWh#S/$X?ն`X]ZlS{~u8or L3ȺVvhfzA .0'QaD* p؇QcŊ>бEVߢLV>XɨLuWץOPED|Q¨vd2Zj|l_y;^&Yó| ZEVTyyr1K#+e,DaeMRG1K8nXr !YԀ# MGC1 ''0lyԀW``S[7MZT28RM55X˾r_<[B>'?ɬd~zF! %X3י(6ra+0yF$ıR27(e3JH TZP_&Y D84Z@x(h)(I(Ky1D Je.;[#PYi+Ui$)qm7867969\I'襰EN㊰P,j ৈQQkN-=v@[|fN޻1󷧟Aᣫ?iWQ2)յ%4-Bk1XTi 4E^*}U#A6i —c7ۡe;|L,d6[^Fw$z,kNm?@*8 (3_ lO#p1 n=a\Q<tvns:Ea%xh:ZBZ/^;Q !xv3Wv "sAhH GQL i;UΕ4l;FD֦u6q||$I4R Q:*e*%UZ(?4-0uNkֿ&A@L( 2MUԊViiStjGmYr|K9D`1qռ"c0X~j sT]S MsS 쏞?t-?yש==+_*_5S޾%# Bl#RIY*G;Ƈ |xq+XXƒ9$(&NI?i&+`+T޷W}Agru;㾠]˖:wѓֿ{5CpX /]sC) Hq04R8Dd$C\ Ǹ=<9w Ee`EU#"#EPϡs$13 |$ +t)r/ﴅMJnZ loI+ wjs)ZRdECuQVzrC;ZT~:+ʐgjȫNUjWhhkF"ͷJ@}?Ϫa'Ygg 7?(oU=@B%R@ᷡ3gu&x5<79vsOH3.uG[wZY*/-/0AYϴjε +ZgB<H׿]0fy6UzYKW0"*:'r+1іbSe˼hUZ/:_hL cpwrD`lن5ݢҋ[:ԛ&InaMl֛%uzߠo06r[c{~}zRSB._*z0յV3pUnS&xO8O k С(麀07hRR|(: PX tt $wLؾs{: @o99cRBbVJci`Plz3), !,tPLDPyLyk0ԲUˎ=}Gɢʾ5'Tj__񎬐z&ZŸ?@~o$<-El~T5p=qƠmad0禊>unגJDSW msB\޼{#ݽhWj}%  dĖTv%As 7x[)Ә;UY IV%WԩC"bwN; IlSw +ۼrvY/0&7¡GbVgY`8X~5 F*,oC P8XL-VKtdUU:N85~ԒAPvPKB3Oĩ8flqQR3=@܌k0 j/N>ֈBF !O܃ī\<3*Nh@&ynJdcc=w}kųk6qB$η޺tϿyqK/&4}P6WGMnqM"SF:Np#Dx%)T>jfp4N:iB&xhI~^L;@eu]t݅B/NJFP=i#3`k6oZ*:4>kne.Sh xKH`D'峸֠5gjp:R{mn;v!NqحaQ]Q\WxxvYؘmY/ ;U mxԅ&m@xHUBPJ}KMP+RJ*Ej(WۀsgwܙΜ</qyV$3+*)7M2.:wf+WۀR` z  \ΠÌrD9툅QF=;{u}dԳ'i,Ȼ^B>J^*b M >=l"QS >\~_'kfR ,0@Sh W*Ujy ȩ% vGלtZPsĿxQ0걇׮9\v7,#c0cG<Қ9"1MQ0:S-`|4se{@՜Zk&N2 pf=e:l%$C:꒬G\BsZeX?/,'<|^0S` $&&RF[Eѯ| K/T>rCOU*k<;;_;pګ;ٲ,v>RhB7[6>ߔ"3oÀi#;8f4E"Ba,$ :YvW$(_`^dQ3w)EjO_a_nJ6F~pLϼMJM/ 'BNj7{Om"J9zyvڳJR4R:^҅R[|iwit&g$=IV}t B`7NIRR!j9ѨL$\d^.ry&Jhgh؞M#qTZR)0`9ͺ.ĴuuR1ͰtζL8 t'B܊8-J&1q ;d,Lχ`1m\3exaΊ]\x~%͋_|kd`$S~dN ,[I[vܮC$lKKgKDg #rSs{qq)Iv̚/>%$={pp̡үl#X՛^K^xK[FOOl\$෷44/n7=t"qjh1`I BH@1b ~ ]H˦y&DZ3!u9AMr)t%|EPc\!c~l.+"+G9Juz!rn84p9#QsΑɳb\L|Npi @Mݼϛ]gvHq%H [ooG)[648ߜ TT0F4?&Jwl3;.(J17A(u!+>؊fMOV>~Q%v?>fGɞV/ x%buZIQzJKg6uP; *Thi{({A&T;jc8_g6INLP|MzNQ+n0дIڪnBIQ!BBFUKhp%)"P" )2)U@Z;_CSۏ{y:#3ӛvn֯7u"F#X3O fZ5W,rt#m8B,_ӷSF:̧+vu6siy+>}s#@7G`O"pbja$V%BJQV#T!YU; IgD:O]]5νC^wu Ft$l Qň zI2 @$ˇ mb9c׷ ɹbr"tדiaGoE,",o<DE\~# ?o'=zL:MBR%Qb8Ly&:eGd11yAൈ4'9u hCzѣZji`n"*X@/Xޮ֨i@OUXn2 2MjSh!leRpv^LXg 5;JXWuN4,2iJX?^ba.{Ž&KKܯ B/ =TQ)L^Xt4d5vXnm̪|ybϘGDf*sDR|ؼ"2y"F'(ſ~]w9p2!GG̀ m6L.P [UW|L݌*50[ TU28ӚY6b'=@ mU|@ Qek2YS!Z)&_vUzkiE{5x+P>6X윮67Džom:"3~7pZ&xms7Rilf!0rB4ctN> dd._6b`5:VвZBonbKNďBHԺ!M)2FfUc6ݨBsQєBC%L`2{ݻr˭_dѳ@o j[S6!!lv;%?~ڶ(%x䌯B&10`!q&7)]`2kCP:%{DʖS kOIn"/k$! }/ݯ2^$;!9& 'a: T^tONԫЫ8XkMH(K?U"zMd_LG3"QhXd|f*@(:20ʆ6߆hB;#t=70XoayvpmS*w&0j;C a@ݵi$q 6uQ gmx؇J!Z_5YuQϮiUK HЋu1lIj<uܚդXm>pHq&թzd h' <1Eu֪y̝%[f)A]]#O:v8H ;Œg7{Q38A6ʆ)w/]qhk9y)fW̳kv[%ݚ픧J{`_\dR웰~{W06{ve8 |8+`O}\[[Xa(8'< vlX{?w,b5UpF~mo7y yu0cqu {8v@afOcLJ*V?ܗ}lVϽ%((`m K73NʪP bWb6feЁYqN8dE7FY\m>[o2gO۹ 8Ȑ-S# ! p)¾WlFmFfm6}F{iog/jlL־Te|t%*Al+b;dVh VY&j*_Ī5|"gl}vEzmđ.zf̚7S))qK7>NO풩啴zE=9[g/GA'vt)6Ah*%G3fKbyz.ls =Sz :Gq#5i9c;8W~}V2d|?}0]`3 |xt7^t|KrZG4gm9,>\7ZΑT'.Dk^МCϚ}zAN!6_I%}Te*BSN%UzWzG>u J'e)cd 㚬e [K]$o$6{ctMvN ΧQV]'m=!?ʥڔM_leW0oZTGk .,'pV۳t]7Fua'3AfRO_Gd>a~~[/b:@ Zlrˤ;8=/~4'(0}`!|3UdY)5RNwD{|y͑5y¼ km8wImoUI{,43_'r,hn⮙=aa 8 |kߟgURhe!&s)*NW?#/x9u]DO3ϩVI^.?Hl PJ3fZP`/Jυ np?kw™%ӕk}ן od8)tn. b_!e뎥k̋2ƕd<𛒡3F$nST~? ɰ-"_wava>{Q?gVУ:{vř N푋+J߶ْ wʄ g 9mA:$(wNki2[qL2]nHOt/A)f\ g ಈ3}6(oL7h';/{``0ߥ)l>VjE%NOߢ3 {}߁v3Rº2sSz ~+#`{z~W X?yN߽2ڷk~΃P7(ejs4C4Go%rZާۑ7NgO&LyMMyZjlǐֱ+1 Ukg_a]Yyʑ:+W72ck4`dՌ#`ߝ6+hccRF+\2qK{(Yro€P,Oo;^wKv}^Tό]o ?!ǽLƅ91 GhߛT SH!:@^ @OOԋ8Gn?=c Q͞vљ2 | ς]sȺ5 Nj]rdfu n1B+&|k|LOɐ~Y@Ch*i^Ռ~ӹyJ{ܱ\mˇr_ǕCڪ|(d]j]ʇA`]}w`><&Cc]se>WdS|J8O䱭;Mž!d,'Hw\Jx B̡N߰ѺO/'Ygtۗm}mp}`۟xzw v r[}ގuE[~vm$>|umƒl kn\­y~/*|\bu߸l|bMS6.QOtȓRA}x8_6}V0z R9 2߄.gr~[j\ 's^4t 2d+9pdhgSQx^pl>a{ej@4G in]/y)o3ү ]GjYo}Z+/gLJd3fƋ 14gMxh _$~L(CB0Y\X*OGN*}f_%&ֳGCbIQj[yۚj{hbW֦h"Yƙ8;_פ:*)Bi`5~fl0NyMP"CucKduz6*5]/ K]x Gm;/5FEd{s1S$/x#6\e@|{vịwZYc|twK87ez7!{Hv|'h;K~2\m+cdmձ -my۸Rc-R!#eF\#MP=z9,3V . Zz.=TY'PMdi1@0˝_}?]x;-o/|2RTNMWb'8 w\/g dSBp#K0[e)o|N} Fx9Y}JMҀ&n{^ICQ#SQ~mEa-.SV'SHv:bl%sH. fI/'^vMo<.ư*gp@| E2$%=+ %4&9wudwfc!!%e<{(ZYo#`3& gZ2d[~wwx=달K"{uҟ/y6jeu"Luwx*i-Uc>EZRljµ]'c.P2GG-ʩ~sa4Gw|f?G8m|[ .2KWi[=G`ūN&PVt(sw|fNQ'g =]Ϳ1Q\M\5'{y k@w/;ݾtTZol WEߓ>*#\k-KR2I|D}7^}T3ТoԷx;ew^/{;cw)URd.+,~qӬ､kU/-냼r>܅W-&7{Ħϭ4?5wqSAӖ+N6]gI]sӘ|-!=yH]W&^5Hטq{T&:, +u魱uo9uˊM8_9=ƩIti6Ks4<%kB_o*zNs6zl01d;7?7'r]tK67_^;`E[^LRc gi2\o509ϕ7ލr}P9<N`ҷ4l_:4e]6wH}] *cFc=qnP5OCW4yEk2p7Ӗ`boe\eu{^XB =3($@Q!BDDF, *X qft@b)[J,-mA.ZRJA⒯s<jҙδ3d~;sI/w-F׉m(/RfƓ!g 99$6T3f~9;eU6|bSgs65Q#¶ĢFyϞhd^d䏴i"inv[#{j\"s&ޛO@=5u95Qkc[\rm=H1瞜>m16cp9ffDwҎuj 60RpTBWe>+ccSc۔"]-׸o+è˞TUgY& p޸"ivmg,3:A])l5ƕGf#(_PkHG A@n L2"c4u <bȉ-38;?t%tG|=-b_&0h6(jܛo>'6 vO4'`A?~=z30REd^]QK@؛';i*1`l;Ɖ/N:)N` 彰]8"o,Dwr4]u]L[$Db=i ii7tBN 2/ќ"u"c*OU1o7ц c^QbK)c>9 $ 9%4v >T/VY| {8efSnfU˽ʘZPwc7Я3{=Pރo0Y;ke; yQW:N}͛$팃̨2 wv*ɑ /Q # d+L$Y~M{@w2~1z|_Ml c t+l+}hO6Վ7?3VsZϳ%Zh];듽/;0]J3D0z7|كio61&uV68S;1!ށU+͌wP֐EbMrȫcoF1_3^)P*agYbl#HP}cZ}#z>L߆'q!V00vަQ.3~;e5ޡsaf"~>!^x8H]cu`7;mh{a}qej܆RgoAM8[m/<~6Vrf:MoYY#ۑ:>JX|]e}ӆq\I6z&&; < }/L$oe6੠{KO0'3i^;f܋`#hnr:5 =ԽZp\f ۖp `h& f9*No0m4;8R_q <|zd m5mw3|W` h%45!ͤW쿂{[tΖw M^/uu'glG:㡎6R|Tcg*ՆZ+Ok׎j㉼Ǵt49bh$H7BmTĴ<_IJ_$M}}u 3|&d_3d)be8X!VV&F*g\U+J20eQJ٪J}|_pG'%e #rه$kL35`(f8>>{{h `X,=H;{WnI)vw!LH &`z7yn)jc.,y{%v g;RG:l\WenY wk" i8 #@1nxvlx A> &d5PwW+[kboHK߄vBϱ7LJ'cC y\ NlځN8 Vgr rY &XꟐwXbr!\1'\:C4py|o=KW,!\ðp%Dg +To66U*cI]$jԄ;slRKTBnDu' շPTwPIu/ӍX ^WE9F4]Toz9ܹN2~qA?цbEkkqOd˓;4͛=I\>80K>pff1,AU``סR [v8 ,Ųdċ0QtKNQj}5vmߡuPv:sN%)/eiKvVܺ }ּ[7麬gvD\z#I 8ثӱlkz.ێ; _?l5?fK WB]:ب6' pTO5~۱]=-8FgS]/T}i9;[ ϔ%f]InxioVYYz-[jexW2XhOQgG(POe-noNRz& Rӛ9:Umo&zZO=cUme" }W]0΅^y&6<`}3iGp*;:_i á,+y[aܒ<+҂Gՙ+)!XR"yET& Ɇɩċ+Fp%B's3W &)(NLjCR1I{RK9-3)Ǒ΃wZpCЀcCU>d4,P\!#ׂF>'[$iAQ 3ۻ{un]K ^}H+E.\DnI+ u-^m;P]TGn:Q} ./h}(Dh_pimPՉKBwY}Gc#5:&0\R eAâJCtÂ@ Ԏpc6cv- .F@ڈYAHM\\EEfj6@r: endstream endobj 2021 0 obj [2045 0 R] endobj 2022 0 obj <>stream H\͊0OPH.<d k |.l@G2&aUk,|lhf]iYIB^qT/_ B,LC1( ~i {ګB |lj6,ln@zf+Ks^ZBebN|.X9*L+ɶJAUVVaN~OxG"NU"rH@{42h#99r3ze‘%g P G-Y  :B;=CgU TB=dGCA=js)PgFs:$țn5=ޤ sQ 0/)l endstream endobj 2045 0 obj <> endobj 2046 0 obj <> endobj 2047 0 obj <> endobj 2048 0 obj <>stream Hj` `j~w@6N endstream endobj 2049 0 obj <>stream H\U T{A67MQ\ƍ" EeQA%(Ƞ$E1ZcDCтF5=MML$դ5ҞDw0h{޼޻.߻@^Āž];yf?H?Ε u,sJ  X|(dN < tƓǸ)X m3y^ES'%#sSD $a &{XR~RQe\6F6Oi#Jlq S Xe"Xꀺkyw x(#i!DK,fuUSnYa=u!NC˨66jstSYb-=LP2BZ[bwnj3"a{*vpdMh%+NQ(NvLKVz >j`+:}C]&&'C,ϋbha:')~Ყd̑%UtD^S6բL9NjڻZ%R}>|վz_y ] mB$n՜qq;D̤TF=mҧt}|'Qb"ӳ"_Mbhŏ*d{Ee̗Y- yF~!=&SRjꆺNk_[-EF˿O[\FQ'.p#]S"Yqy&dLT%S襕[4*P)eLh<%pKβrK0-'l9@E\^!څ@ [bYpB%jٰ8$h9'x7`}!҄8/gu\_S*2\}bK_K(T^љ >n("a mq ѢqYodj2kQf-[HhbSvWrW=(W1#eDp缘53k|*whdFh]i_ocYbs bTXc-FRo)J$We-Ռ^qIdߗM/{էsn,<8y L{9rUolyw)EH B˪LV?`|5\7rW,Zh9rN5qȤJ>l~7p@~1}<޽=z'޵KXN;  l`hJ Bӑҍ(c7op:o>.c61q$I$JR= 1ӡ)g3>ő6~S¼tg'E7ȥ;<^+&;ccPlsFau!as8HGCvIΔnv{NlAɳ 8FDfư$63z?ŜkYo<{潓3&m?sJ9S&B-30? sD!s5 Iy!HN01xxg-Q2eJ'1FO%)jcfFۍw'pיEAN^d>U&LǪ_^6u @٤KPy`vFgS2eU-/[܇܇ƥB=qͫ9u-:O3T q`]P M\͛Oky\Ԩ[T2D&ъJʩܖB68M+m)!( >qDI@ #\T9Fh2[\M H+7h90 _x1GYC1a?Θ9L߰VPѤ(̪/E tkca(U!*lE"`)orr1**˫!پ]0F}:gMzG0+DSڞ8c,B>F8q@HYO~Ezfëh]&ngnG}twT$aCbl |璦Wf5yRAXBЖq(xo\*h2/e IRVe ӈ-荡 'nUܱ\la.l]5k&.-s6 MCxu*kdž?r}l5{%Fgi{59/q79mmqo{˹ >sV_B/}!aM?p)艇d` =`4B}8n?]K8o CII?h-~?tNYuUK]/f#ܑlk>TC"Pd`?7 P]g޽d2 mplk Ot5t6t@G]_6IxW=g@@F^` 060vٍkؕA Z@[.Q,ofD|B]̶)TMA]bUoK @;|OuzF3S,> wag34/NJG) PZ=t Pr QlQǵqPJi|_0 x7"h@>3ݟ<}bfk~Zy*\yėoMͽ~zqN28wydk`2H&Ӂ}Cr&9\ ,%\Ho6x:MܔVi}:QD3m bC!],_:r0u%t״ɮ'z.h/ ?~#|\ )[zM\"WŷĪzK|OoUFVpEMh$~ApE~K 1R(F-p-Hpwt!ZS$&_oO"HcRW#IAY³Eۭ')t?R۝oC@pE?~t9 wZ;tJ;^ܕ(r q{UgO=AhSӷinin[Ͷ‡RZTRBRvlG?88ľqMu6qqy;}s센h Q VBR2blR;F4 )xYFKi0LBLϗݓ~ߣ⵭P(h*yA9ZI|Syauמõwlap;wl"]vƱW ol[='_2k Gf4wv-pWΟi2q乭+xQk:r+Ag=:gXF( Xb)b{܄6I1E ;!h  tVd]sМ!2ה;GRq™e/ ,[{Z/鍪>-"sm|EuU;~(?TUKݮg70[Y`QtY{>F2 =XC>SEhgkdr_蝱PJ`0Ʈb{-WE ZsjyN(PQLJ3D"'pQ %abg)d 5GZ0Y?H($;H*p54טT'Lpã(&"MZxQ`Tu4 -VG_Z?ݷvġȖ;پoO|X ^?غ?_ޠh@%s@v9!nfe~wFaOp@w{Q!2ři.t-%J3$l vjmx1}#sd1c`:4PPlcbM`QfQwz5AQ .*U=TwXZ4A` ~_3V:I1q '0U<1yYNn*9ujk brtoTd ('),c"rU$VI Ou % O2U Xɠ+oāZ,b̷׍d 1ރx{8Qt!^`јG Orl© lyI̙-ƅl 7>Q3#CY:iJ{i ?y@.qZ})G;ABV'pH6;c2qab,R/m/7{W C2\>%Sq:ޭ&4^yr;E9_$ڧlGEEkSCeӐ,sJ7aй1>I‚ y=Q+h}%p T6Eh6  sH|AB/ C?K"O^[k7ZvinxOmj07) rd[M_^Y2a Y:{pɢTW.5A߱:%$ZNMϢ!r!7y-X˭VKrZ1,.L ]o9eQvqI?x9㈚MD *Fg;@b0&=z"D;!v2UF)mf8b@H*3_[I" 9tjj;<(ۑ`H6@aX2ZOe9!:YH r/!3Q2u絶DU 7jv+.N-=>yW.77sl1տުGolӛgXo毣K7{Ϛufp| p}[8بg+&+y<ϓ  iz1$LŌP,fqyHeK-V `o;Lq|$sXsR6ikCML?T)-QnE'AvG=uttw@aDtP+P\<`Rr@5d:jIJX^˰Opؚ "/hDB([hP!tE@t0o,;t(%RR<}Ia }CcK4^FѾ+K"L e,"DF?B&L׶>Yn%[dY6wIȡ^q񬢑)|w (JQa-eүWn*2><.eE&(0bȪzUQ뒁YGBRaSut: ,RxΗ^:+}rr ke O8}`pٲt#e]ds:"´"+sC afF50!H "EFtz/TzyTǕũ+ 3mu]|#{ ^/#Hy$r)!IߢO2MkO㧹zH6 >1 sDw;^v,:.)πg3=~6߰7 |y&v.(~*'&wȴc{P9w)V:N9)c/2,\kk~Ivtd}_~!~QGAGA1a714zf]3c^ I5N+Fc9E 7`ՂPG^c K6ZuOf0i<מ!&]KYGoȴ@aAr>L@l2 OHdSxc&S$85BKY60h_}ҝR-5yrBx G3\&jl%՛U; ՈVm'r̛?QN%pY >l:DVz&P qmһ76HNW/YҁG^~S>[ؽ[}Ycwd7D(p?Ux*@I0K|0 ET~OᤜGd!2fHdƕ p s\קfXg\eY"# Fgɽ9I.Jq#8Hy8 ~J S@pi ϰ"7 r&7m}w>|>ıtblAh!F`c쫭ZuckCEK¤еCۘTi*H[ZcBU"UH6i#MVlbab~g}~{}7ctD?wpwBYNB93T]*gY ZSjc\QhH3!YY|$'BLD7fo;WKSߓ+ۋ?w''޽ ෑR^wB`r'bx8RUѐl񃢾.)s4Rf\$r>s٧뒚d<zȵv|SK==PWڀ %`tz0@m1Wf{VT5D*!i+Ǔd9~Æl>fQM!z_~襼껢ƨ[l~)(RFᬪ ---;u@]B:~}>7W6|gߦ+WG(cuɂV؞mn+TGOh dҗȎnF?6 K6X9Uџk8;}Yyfء?pbG+z٤;IIހw&KkK!D13ǼJ=i^ :"c(mK$tO9IƒIDC`t-&7AqJx)TFLUH<R-x$x9=k𤬛HAb=V5Lhp4 ҡ~sR|軶P\Emjd$}fzey33O+̝ @ώSG{com͏<: qXp/\\Ga(=)Tx%b>账2錨jh9,RI,7;A˘+qbIqp-cB9;8"ra2/D|uIGQ )S1i# cQ6`Kxz.9ā.p"F> hʒjy*}癮QLAT>*RQDZ+S l/[6c4$~gjcl?ܝ ^lN6dX`kRRKZSj>E;K˪KޥOsezMt)}X>c*P"Gxtᐬʁh"@Is!pH18KghL4I夥q#Bq%GJSłJ=/-CO.5J3Ҝ$K  94BQ׻Ykcxi(yQhP`OO/Lnֵu@s|kh/ ЯQD3qrЌt+)`9W;ߠ64Qt8M\ZjԎ1lI&qR!Jh ]r\Zv#wrUW9G Ōވ;h^oYD1W5ppFYGq.n仗!%D2 p<0Pb'ָbBHX zP#GIf 0fk& CRqh>2›`]qϲզ#wo\c-@.~p}V%I>z[Kϗ2-iE~?ɶ;y~#!lF7:E>NNq4c2{[\cӺwIt"SOI(187 XkA (.AE 3 s+džF lr(B:ajZN']&jU^b*r&'7 rhp"8dRFNݏBgaDL2Z]n-Ú~>*w7CC+*Ԑ|1BALHF) 7' ' N _w^gwFA[ Ynƚ(8!`,AHD%K%ESnЩ*."&"Hx).,:b&)KXFt :* dX-ZΩ{d.HWL.e=b^j4zoP)[Z`8?;{;6S @6)j)6TmQ8ryb) M,cQn!p}(EjMZLףZ|3{3sZ4-<4$zŮ#vNLrv^EQ8o='>Mlf&"(?1Qq2LR©)F9EV_,B(w޽ ePyHOm EJ) $"eLH[QfxMCQd|h\0 >/ (yeԸh[Ur7'ß9^ S5.^ iڤ6 tNW9 )x&̇[ьg>==ݷu5ؿ%+тY=PXW)7K{~V|׫X~U7YYiqt?u-;iUVri\dS*l* ըG}>ͮ~NS|[^*Q_?ޚ;!׃#yI&FϽe-epǿۗ̚iyJ^ ??r2rÔ^\(;,(Lc͓RP`ej>˗JSOmB0xJf,/hjY\b[]w|]݊/r$m$Ҟ}kk\QL߸18KoK),tʝ#c w!NX==;Gl $et#&G-c3Ox2Z.J~SO^|K,`P<{ X,9=bV^Gʹ[H딃 3:lw 4{i?߿g]1?*|W-OLfFM*~bvB{p*+ _@ּa--S!ʇ/c/\_]aQ|xviZ<ؿ9ge;wV1kХiAg-ާfż& ,6+7+zO%$bϸLT ·\q3sZqDR!{;ޛ,739|=:|k~b 7OSRo]2yҞ m; k% $hkl2v-l{r=ú!|3W%ӹCkTOiWЮerԈ{kfw n=kNzz;&c)g$ ?2YlJYB?ɸR[ݽ-}ڶTs$ʤ{bm u7߇Գcl+f Dlv&0J{{ƣgNGd4NgΟB9"WD`)/|D2Fomud'șJ38T)N1iumrwWq6^GEJۺ(]Wwep} 7; 7S̾{- }DëbY|!)%M~r,ikCӐPFN].jc"|A^ًAdLDe7| An!7[jo-蟡υ~ytn_h>ˣ?W&m7qp?;ѷFI/xKuyϱ8d?٘*ͣ5揁72Ha('GW͝5Ej qS]3]A w P3߉|m .bWn+~MaL }k;IL'SGF<܀J4(8e0·䌑JoRyi<}IK^i v. mD8Miƀ>taƭU0}EO+¸11&%ژ?(ᜣ9oL$.?=n.YA,[m,!/:a9)w)1֘_-3TԮ λOc\i`c.-Bantl!v빲g)Cݯg^Wp&;|!S|{_] L)Y@]m7׶ 5v)6dQJ[X/? yc'yvǦdI>$R:{?܌^lHVe˓vTPKk~źu/HEE* Re|]}͓Ϝ+SbgH2u?Aoy7[v+ڀ'||Svl}dm?f!.:EX-s"q.6ӹcGraڪrG ʋP< GzQ( Q(p &D| :GvLB'ޱWy>|7 '"9}W}wz?0|_Ka-Li#:_8΄X6ؖ`LgESxvlM2_c0m}2sַp#ޔ-vw`=t/h_m~A0+3EՅTF[eUZW!I ýl{:b+|}6}$fu7_e Lоok#daM mOB7}Xfk.㉡MޭrKrl[wlUx%·m|x2Bf%΢<%ONye2kvN8vkR{%8p&Z<̘1r&͚Y{&i4OqEωep"k4#NZ"Z$pS20q dW7:OP۷&fI«֘klͬ6w vʰ>h^Q9g*u>HY/પ3$$I 4-T )eiLJҌ)a1#)`E:LXRL)HVhlK "*3- Zd9y yv{޳ݳ| x^fgMNtG7keQ3.JeBݥT|I>lgtEhr*L)\'bjp3L :PuNhuM}W jTrcP*=uWD8y=wg$3}=ݮ㗡>}mo-ꮁFY҆l7kxױӯon[D6X)M9-JJRXo%!4ouOAѱ˰ Тq3ЕJFHxbtuqv <`OjZ"bUs z}pצQ!3u9 T˰GJ_wuwωYݽ=q[q9 '4Xva5{{^<mMSȸPv^ȑNk+\:He78i|A%oA{>=d9M I:(bQntO8+<-0Ca~r'jo=[ cr۬cjϯn_3xoxZO8f[?X/@iIźĹ}-+N5ڧ\jkK̃3wh4GY dT;]#`K o%YKhME;YxltPցGhz~ FOՂ"a߇MĵOPm4.Ն^WcՊbz2%E!Ю ;Nҵ:cIMH %t{ n^VKG 4LlXT猧胣8hZICic;h!~vT^ƹ+:d{s Πt\Xk; UxD8BEu;kJz%qh_6OU1v3 @OΡb$߇rdntl-s.絘KlQi-' Cs;k@t} 㻗E.{>Gw0T0{NB1r{(?6/qEu Mw3NTNy}TF dʯUĻ=F-)ۋNڇ7F)+^ݯLb9F׈~/.ˠM'r{{9_ SÙ< }Fc:ľH(UaƧS5߲Z#eIig BfuH waFf[UlDI ?.&J;1!^2r{}ͷtiݴ^v ;i3Rby^WJ551'Q4 v:wQ.p(`gjTu< ];YpN;<9?9]\5i.(*5~o 9sh3llM+qCŐmG{:%=QJ OE- 5R5=/bl FJPb,|.MR~>RȀ>s(cx [!rQƨE^z#QOs?,mI*-Ec m{!E8OhEi COE!-&{ޝaı(ijQꈽx~;-ާU U94wSԠh5I}CO͜ Ӳszv78%5 <4bF`57tht&v] <[e<>if{=!րD9Y=G>T?d5jMiq"{FO}Qީ=:嵐j*q=In91,澗ua˽OS7;?}:zВM!+]gSUDM< K0 cL@u?-|?-O.(f;e`UY>S"^Wh_ XLjG7QU^~ ffQ?`jr 鳆"i}8Ȗwe%ȵ4p5`|=}r&)?¯|흠,ƽ;HyuӤop&wccwWMx4L-URތ5?@m<i1y)9FEvj%QBneSh[jR{VY^A^&e'!ζCU M(=ZHERU+k)Y凜y}㗰v Ed;VWú}չh[J|=\&3RPYI0YffrÚihYC?l'7ʋZB#Wh.nUZ$: ^ް8= O/ܕ<Uon&$)5Ӑ !$B3f&fnS`NXay HR3a:U ꠎ:Zs@@XuBnѣ[r?m)N9K=3rqKϮoǻIICǷM]`ףּ MZ Jؿ}٘i&ߏ#9M{o8ea&n5}'hLIox>3y=H CˍfTVyGQ.U'Q|8Ǟ߂si@g{Cx غY=5{?A5 giٖ`k1D~oAA|.F6-ؗP(21l37'ѷ1g}X @m& ^O^2V):>thC{Яl͆]&!-(¾Mog1/aawo UyI_K1٬&l||!^ȳB܋hPꃔﶇq'gD~h4yƩJ{8ް6?}3@fmB[1G Q9ޫ` *`?ghlx aN/o'Y+| ~~ˤ {'# k[ؼWsX`lFY6[9]?yQ襠 d8U> 6As]neBJw~>9m>cBw BP|\K+LX{s|vdCADG4y;QlѴf$s!sj@\+'(.Ck ʜ ԌX!fމzz7lwl(==H=|Tp$TN3eE^zGP6Ċ.1>'1!ُu"ǂSH~9c'Z^1Ӆ\A9rX6 rrlaQ#_(8bEGfJ?DzdP)s:=J/$V@P(.{QV^Z\R,^$3FbD(Y+ajmKybk`OOc:4ju62uHW#D1Q ePg hGlmt㢦ƶPPs8[#DP)Gb %xWgЊF^ Xqk[:` ˃V< EEeA+E5˫̨mD:vi8~̻ 6׷M0}[}g~¦yi3}ϰ),`oq6i0+t\Dž;K~9p ְgl8L2E gyܗQ9M@ DZ\6`hg.jͥ` 'b"`oȔ,w`Kڞ;KeElZ{hmd]T)3ҍBa9dףqh7˦nB58a`} H,LlmȧM{I^Y_Y]`0" A;/ /00s9L@X^e|3%B/ƫ.6* {wRnW,vt ,Plg]هVZN@45d[C"DFTL`8;5uښi4D Aimw93w3?ÆO8`C,,9##Uwxj;N}^YJcGH7&or:=qH† Gxg!6,ea@c 0~@a߸c_zgZW }* G? c7Iy>apBT{W3jaS@&vy̑@ +|l@M}۝`^^ՙx MaFix'!x'>0z <~< 2!6*MJ #Wbm/IXYj@~ڣ>L#N6R;Fmst JaSk[(֩v;56=wCR^TFt; 8*Ǟp k*[&DZ[M|sLpTGO~[ø}qaq汍1<{ 4@݆OJM=q s`ߕ N<~mY\VFnߤJC1X{'Ҭ4{ir_H0d٤xtg<^sKW^?z Q? 4^=?Ky "jR:n,H$NiTeb]F },ciޣkM4߀%5]I1D/@1 <:XDBY,SA+L!Jz4IV6/0V|GUޕ}V҂sziΟ .wȹ!N@ YgQ՝N(8J[:IG"tՉ(J>*XDޕ[_uNZNW Z8C/?zQUuK"YVh"t:Ni#NtI]t IJ]2:?J=K*IMyOBdRjZl 5 -8RT)UJTz*I%ǖ$L>zU4M5M115 :ep"? ;O:u}VDBs|:Vb4$rZttI )9s̮|boΚߘfcKsm`bbuis\i1W+"r+ Z;J5b˰m[V%H]YI Y:MHˬˈn-Zp70͉,1$?q 46. ^F7W#t {@aqJζXccޫ#M}%m`.qln1O@ O!ki8+lԠ16 Rkq΋{Zչ]ʋ%Y:Dae9R1·ٗ§mw;})3sKr<А㋣Z , endstream endobj 2019 0 obj [2050 0 R] endobj 2020 0 obj <>stream H\͊0OPH.<d k |.l@G2&aUk,|lhf]iYIB^qT/_ B,LC1( ~i {ګB |lj6,ln@zf+Ks^ZBebN|.X9*L+ɶJAUVVaN~OxG"NU"rH@{42h#99r3ze‘%g P G-Y  :B;=CgU TB=dGCA=js)PgFs:$țn5=ޤ sQ 0/)l endstream endobj 2050 0 obj <> endobj 2051 0 obj <> endobj 2052 0 obj <> endobj 2053 0 obj <>stream Hj` `j~w@6N endstream endobj 2054 0 obj <>stream H\U T{A67MQ\ƍ" EeQ8 `b1x1nU(ZژQhjbڈFsϛw{{01BSyygnPwR:dȞǗyv:x1nJ0FDL^'񺗷dao#c@ye=ҝa],\pBz`wf w RMhesD MX| P9ぜT)ͻ&%Z.d&b?vvxxІy+QCwJL/@:IHӝhJs 4-4Gnl3Mm|v;_НQ4 4ҟ4VWH-Cmp!ZL6FD: S͑4i 7&ei8Rg;fp2Ƕ ͌aI5mf@4xI;[ܱ| !=cnWQ?/YyTWçݤU>_nt=|j+z}lz8.[gk*eP_qF;(W槱 d-l)؜/#9r=ik#Z=ѓ['&4aY&e=@xĶq\g\/iYȕM%R"9D%-NڪѠA/lӴ@E&6@+;@ݠ=zP Ѡp&;7K%?o޼fӐRR kaeaOyv(Rob')I1O:ljLb'`O1zT Gf!|&FqZ:Y,ٸB sٷrP/ɛ/LO쑚NϘWl)ubN4 lpW̽9 Nv0.$噆0"9tYRJFʔ)Ǽ/?ꧨ^jnm7> `8a8\g ÷fO8]{AƓ\T0Tf z{y!d(gj.Ayk aLʔQ0V*jlqr& ı7Ե<<Rcg+itB04q5o>UsYSjnR!:_#G+*r+s[ 2(7Q8/3*T$" Bf(f0yyK'̸NF`xɢƍs$m&ȎPr}S6٢ʈ.o1Ks52H"ܠ(g/| sg#HvZpbg Ƅy8cd 2}òo[AEs귢:3j*ЭABEW9{D튀Y^ȉǨ,G4fv}ol 7iܯ ՞Ni{R㌱55?#yf<éwU%Ix{Jcoqu,Hجr6R* &; a ifaۍoS;J&`-d󲹖"E\0c+s,"7%ǁAmͩT5rm&.((01˳J!ГlY1]VVo뙅q t nlWTl&} ޑS9ȆB)qO KZ\*^V+ˢI5.b B[ơdqA$FP*g-@_S$eJa[] L#C7ϞVYrSsQ=*Du7{XLex:( +6 !dԆ*4 Հ21C3sea A&GyŽ%.綃mJZ=ks| z5ѧ{'q0tG`  M@w/⼍3& $Il嶈zOO9fU{^o.y/_v;pGR@u%^߀$@u=zڒDDs-H&Xjm GAm~ t1ۦP7uU.1&:Vx>}YFNi4F3O܅f{P:5*=MLCijIt%0'oxCIZ(DI@kCF9A){}ho38JC ;4\zW)ڣү|gwg׮=f~kw:>(zs_65Rdg9F:ɐ xD L ətr)|>p!Y6O? 봪w6qS:[z_uGNʹ 7/pttџF`֕O;]'깠(@ys-8/Rjo6K\LpHJ_-=CUΦYQ71DtIQ={`,0KqXܻ], ]>хkM4B&;|?QR~#I_&2g R0m0HmwbV e=Yv0X޶[i]I\+{qW-ĭmV=lzMNNsoi[G/pKKr6`4{S}P<}`j4@wCc7ey繳|_αB|RF P60XIH IihWIh6 PƦh heb-TB3 1u,Ξc;?_.wO}׶BeOQhY['O:3煹S]{ޱ/qHv^5m/+?Z۞|ɠE+ڵ]9Ҧfc7{/b:|zNtPrC(Yl 䄸e|֛)kuo=]U܁*E=S̆g0:YlD8+Jg)t&†fMV-CȎEt;;njU B x;@b-6ڮF E Za`AG5TPa kv>O)'p}q\Xc$ŘC, )ꀝE"/*@2bi90s\LMh,(vJuه24B-tDQW#5Q,;3TBя.#ʓX(W T.(&lr6gSٮqT[Api%3_9u+5~v_}۾5nhf竿{1_i0dnHKHZKNi54;qH )S _]#wxD(A)XdF`y̅\ba+YI0 `͆"+ j#I X`18G.vr7p .^ ԓkRLT2_ۨG xI.:!^?ߐܓ5 Xob}6i'G KH& Izd9܎ש9GTdP1LʭVٓdX%b2<).|??nW*`%J hjZHY/3^71+xއaI4^DJӭx fDc1<ɱ) Zpc'm$1gz4:(cDiKzό eL): xCt:UVi0Ϗgkw\n+2Mj Grm?xF݆|論 W/!ߞJDT>iYyzp|p Xc'\IJzI~3Wn<,\eE##ّhx$w%_;)ymgR8} Xazt2N}Ԋ z[׫ev=O_𽯴ʡz\VZ/N}lˣh*>Th.%JMIŸֶiӧj_ f/Or8Ixk [DfNcs_\Js;(w;JmPK\W llw}8v8f-@K̓jI;(hSiu@cӚU;UJ !"D5UڦN4*el4bgG޻r>un~\-j`U]| n{ٽRH07MĢhJ ;rVF>^*ّZßy\#xGSh2(q߁J5d>qoGIkҗh=zOxQ&no z9˿7'K]<>n+CG5*8n"a/AKT#|EՠI gt=I!8Pd%(gX5hX$7`j'l|-P #Nh]h:mBcQ5zf)K4gNJnryVfyfjs7Sp:L4XTTWT`j\x芵C!gڧO3 @ xq |g#;h'pG=jc@ n+8RPI$|(ix#itB DQ#t.>?y9Wo Wlhٱ=ܤ$ʑ-;wle7}yag%3;?1`Hfu%&VSu_8}<|ޒ#j65Lt hd<` bT=NS$>2CL#4ihxf̻"|ijn%ZbD. f< fHh`\oGbo#N9SsA(cxk=QXd9F"1p1j@\Gm׹Z^U1ܨ٭ |:T_αh&{WzٲOonտb'.>kbיY-m4cŸIx[{ck&O A ܣl5'CS1f[ʫӽHyJ>sۋgw'ʏ7; ]}/xEn|,0)gLR)2ؾj p.33 ^nd}lf!l$"z9B,ƳFrj'L8(EJ_(T]+GD~-"^pWEA8~Kf IIOKp|,೘Kexs8_zުVHM{P ʝ*)>%0e}uAA4J8C؋ӊZk{+yy!kc %\C#(UW?ޫz|R{QAWT/gHk3Qwa$/xI0nR")U?#a˥D$ |>4}>Β!,$L%%߅{ٱ+<Aτtn |.߰7|X$K !.ꎡAzX;AJ'bk<˰Tr9&|A{`yTEe%zr%Zn_`v%ϰyj+$\:9F) -W ^^By͏$.@jM?i^{dv-1g!ņU ~JeD2(<ɧ" N}>vmN#/eq}JwJզ #5X[pTVMaa&}Ġxi2To"W$T#ZE1o\D9fDeE"4+3^jDP'[a녚@yAKFGT,v?#;]ϾfKOyOlaoe==|}=T%T/eTfQ >rLʘ#foHW* dx?Q>ra^a re ,lB$('@ +ōT'' y$%4r78)-Nm<7MpW,?>Na  ІeҲ6fkՍ - BmcR miI i UT?"mڤDZ4MZQ XW}=ylY99v&{ og9 q;vPv|L6e4/hUN1'SsE!jd݃jgg!_@O,[ )"RL R;OgL d' Y6Mm1,@=_k'o$?鱯|~ŷA\YYQ<T!O 2FU7T}բ:Jnž qP.[Hƚ"7Uu0 aV\khG[oߓOLO_ٴoŞ}L_yr\% V[c{ߺ}Rj?Eo<6I_^ ;%5/s{_`YTݧGK|wey ]cݶ~ ϩ5jӥa:&VCx2sYhH C*TίU'>ΉcF!LD,eb$1M$ƍ ƅZ3 _(NQ bK( <(Hs,77Vo FF^vDfS_ z gQZF=B??1~09}[͝>𭑫S>3WBRFMSC3f \A|FDN.҆<7qiQ;IPs%]ΚTK(..t]pi=莸g wU]% a+3sbx#N /=ë;x]g;~\9|syqfŹ^"!\jµ@PXz q#a-IBm&06 Iǡ<oζv =zWÏ޽q-~/;X$h m-ek?_~ʀҷsA 0d'ۮQ2Ǝc|̲}?ǟO895rMm]rM뎢%I=~JN?&AP4`y%t4̭e&(ɹ)j9DtVyPT<,hTKAb9Aw?Noh3TjvgLgV5Tch` H UCsl PRC 3!!$t$H'l:&@Xy_m+ lfƺk΢L`!X.#WL֎Un@\h B[ȻZuƚ,"b}IKL,l\,tT]bvkI; )R^1P3o-yA9lj8ݮ|~\_ݙ9͚F>; ^fŨmW1+Nxwω63 6o33'+#YZ8]'ň+EUg fS3 "i!΋.XuVIYZbuYG>KZ#;>S|UTe1¼8sTJIVٱxILwb"bRيrp Ҫ|]ھ_zSG2導[̽KywߤGd{3T4Ȱ/>) Fم ]Rz%@M3gPNͫszCX(3A M F94]4Aj|{2aMt cm26]los u4Ʊ1KVԴ>=}3 SS4fuAI)i2]űzJ !v)%tYj`xVUW܋fcF"I>~&>S<ȼɏ2 -A(Xl r ~ nw෼jmdFb/ .)oRqy%waGTO 9i?^+{Em#٬TL \ɗ͠6*\KWC$)kd`DFFMlʰ2Qǖ7h=k*ľ;\6pw=G:5'Ú:SB%hzngU AgQA+f|[ ٢n[>۰^& NjT?ıUW-UJLh._?DX%qeQ/Ce&FӒ܌7k*@d"auyAɻx$KFCj EbD5c9̴p1bM3!ĵIC*zn8%#_*\3Z^Zjlņ3b篟(HTQ;W|S/z3Bdv@1OYܰf/1!Z@M_7Nwv/Ҳ`@$Zv4D׭,.ɦ"UTp1?ٶT?7QݩS /(ׯkM[o록p׆_S2ߝZf͔_iִMV-KL\{mX]lߞߝ5 ڿ_D͗ė2rb~hϚGs,3 _#~OOby'WN 0Pu|09|gSY'/ti5I>o)x7/2Vh=#>jCox p, gOE<ǻ'[(V i\~ tbm|JZ|A47fr1^*ݱk|Woh11tY5`x' kVODCRρYu6nm&d(&hF˦_CV@zGoֲIp~L9T`S@Vim4FqZ!@{ ^Ig_1֠OᜋdxRacbxekUhWA/faNyIZ'CVm^^{<17.^~ 4ysvK5xwdytgo{Ua=Ix^4>g.ۻX'0d" 4s ؛>þ!!Φ|ѡSӉZOy\/8˛S3Tݤ*>=2=gP1$Ё\MC>$¾8ALrF*F uR&J<>xv^o@}г|Yc@+1Iec5Os~cH}@;+{3{ɁD]@'( LG^8[Ba&e-M7`y/;z;l=hV krhց![R|n/yђsS&A/Gs\8? lqu]?O wx9O׍h-UmA~{sHsgG˔k=c 7K\<3~>0]HoA=3qЬOL.~qNjҼ:*i|sv:T2 . ĹFp^V#+e < \=kQ;AVS3g?gTe,A5l+փöUy~wwd@p R#F $H -myju|U(JVjۊ(Vh⣥GԎک-:rC;sϷ|sΗA&{'vp4uzH.V5('жsxYNƶ)nzyU2;&Q/kHN{}vj l^&WpMov1ֳF뤧Wαsk2>AzFÚO,ŦD.ϑ%-{/e %{h?PmK5AKLm SDָ9 uX$C~3#wc9-F·З̝=S-#b]=$yRkv#EOu]FrK-%y }ԘѴoVwQrlvb߀^q[w}8H=;Fb. kkHfgdOW[[ m<}v/yDFN{LOq:XI.t/cOM,rEqٺ Y_sm .PrUF9Zy6^o}b&%Zux7&XčR"כI]әMǂu,˞cS=Y4Al8iNζ9C=:7p}(zp=}|-SuͣQ=&<ARCTO.c6^7OvBT8KeckA Z׶*+zwg#5h\uuWf'ܗ`pS.@B~9Y;ѲЗNn ';;`;+&UȇR'W|a?4 eDЕʮF>&|(ߝwLoY䕽(MMʹo~M\}s x䯑+)"F؂\=gAwF#ޡ_XAΎ_V|H$&%:;sOT'GP ")j%rN}[MmhC޷@g.?08ÿ}?~{H>+#B["[B7oںuvVsf>080/k}C2QW߹?`vB$T³yyx~Lnd.2>f'{-N%U8|>癴%Nbbh_NFȞ yj #N'h`jYs{']d,RȳfƫPטGV%7!cFkqqF>-)-$bo}nJVlU:H!)Y>* ({4q</#oXЋY9XfD}̟rbbcy0:rMol2;KuMΐ)4ko˕n8jK8Q.&|Oqb+{2Ty{u/Xn#R;W/GUΠYJΔvsmP]i?lChds 9o0ygzlOC"EλLivkUF<oHNῤ{W[P7T$8] _^a*/m08b3;v$FaQ(Wyz( *ˣP^~;:בBǰoB'sqʋaǤ(Oځ~3wx r"ӗ~o@7SX~(i@”6ү#KLΌmӿ̌m LoȴoyZD?>ΌgVۄ+5؞^V?'3Gn} Ѿ?rjM"{`{`~ C 1SX]HeU&ZXu{)||hJkޠ>ֿܻ׫#6 l^GRkXw3y[0 [=r LX8ې/)4އe+oFr>q}*$?u&^y]2.|Iw yA +dV,SrX4^&fcIH!g[K`{Ì)!#g۬IgO^=^'rȽIcNOY?<%2uL7%WpAzUQ y4 %}kb$m:isbW H ^L 5a՚Sxv1Z:@2:KBI!@@BuJϐRƤ$H-3ЙڊZ VDAe1,Δbieָ)2eJhAwιgGow==Pevd@wtfN^5r_zT -4]Jױ.T f}yJ-\-DB(/> <0m^> UZ]^ygpF!7uңZ[w1]O$ӟ׳|qF2czדj9~:CF::ޢh*mv֋1]}{=бV8{NdcҔbz=$;VB]쮚O@tP"FQc-16h'wޮ65r<8)7:vIڼ|+.;.Q.QA8 4c DT47X}:/<(:zxvOs.zu@FLŹ; pA} lP-(.Vh}jT M\tFRmu5V(Fg!SP"wZ!_K$]=FO [Bh]M}u8oz `z߰~I3q/Qu~Nux\>8sp9Ν4ĝ8RgGerC1 JO`)uPG3M!d[]CtWBOGEZk}mTc7d*VK}(oHFOyzϖт1wXr^k噶y\ ~:13N [ϻl?Iڷ?{Yd買stc߉zL5 /p[׉T*d#Anm]4Q筰{t7DT-ؙG%kJMv*XIJc29$}8|c8{?ʄo*f?cR Ͼ ZyR)g7}`_>U hQojٷXm4ƺ}PCAD_ḇXYf|J1%Yc-5"])} kg_ Y>@NppjTnUŦOT~sbt%-|H6Mn9ـ|:3(%wwN|Y\8N}U@P|^`wP9sep:vFi^ǓeɈq? ̓\h6B RM 36sDR7T ap_3x]bOzdq[^OP#U3 "6ʁ덀`4%$X(Ո i8'ho?^Qhѽ"El*}]Ũ7*43r.Ж2NX4֙@߶R4F+Z >A4\|Pߩ{b2jIzFYj &>؋~P}Zeϡ[SOa{>H|9L *ڌVDLGϪ9ϩ:-;1g`w#\Q;I3^ .i_~aNwFgb sqZkfֹx݃mb` xO^3 ^s3H5YLNV>d檹a'_ZpoՎCNpP2zF#̢Ajl{j[{>81;5]ѧ-ل;:PЕ|F*;^eA0ch00ƔTrA  gv?#XfXu/Q??%qeŏH 蛁WkoxOzqSi:5X跀ny`])>k(ևclI{WY޸Qy\Hk=_׃N:,gžmp#. aAhܻ$W7M gbx< Sh"IM nv_m6: 鴊f;"0 IPu&LDvtZZ{h(ww~u9F£UiGa XC)?C.|(wZH{ ]br6(I2~Iی4Uā{`>`*])8ig=Z^6"UcWKBNweڝW,Zkz.},v(cq~؁%lm>.!=߭ q|9lJ+vo>s[B?O=;'5<<@=+=@vVaÐ74xG'JxI#kSc72s[TV=>>-3vQX`ꔳ#91(JjF3Z 0PB47yoiS ޓ(e3Γ{pB9f-|j4M&U&v{6C;< r &'G\R6uw)W WRm4Hzq6V[>,H3~ ϡmڃx) 4q % 38>Ae8eOxcAmxkfMe5}4Ru_M gosI-8S{Vtږz+nZ"^c5Ǭu|yle#] <vD.B!gz8kHN^BqNK$ƫBPnA<,:]A+KP[xܲlVXX(*:(Z (/Zii?\p-~V?#-ǏyIN_0MVҌ}Z"f- V(GM2Gz+ǰM|l:o>`M@cfaSX86VH`E/hhv^9 _a`j#s4N{f !0 fh/ wK~^4_W]lUҝ]t; @k;Z>Jv $DI$ 5bc ٩ӖL_?$O*OwnDLwsϜ36Ⱦi}`]b䖎5geK 5w+(W;jJO/t=]ӔfR7" 4u.»H,Y5`Od=`¾t0˾p4O5هd%*Hɟ% NT=} 82T[WRMEEQ<~Td˄Hkonj勇q<:2̓/.<<`7pT:[Ii  <\r-m0Dm}׊_EA5h{&UоH%’;&ɥ 6g$nl'kxt}n/;n!:7lo""x#QYpD峴Qԟ4K-"g7qqU94I錺 G8#j/?h5;!eԽ,aiޣ]U&gێŮQ失"M>t>s/E}ܷ[Ҩܢ,WN*L! r4IV+ V|GUޕ[=9HӜ}aj1.`^KS;#ȹ;il_C2' )K+"tmJh| 7 ܗY_OΦ3gV v+9߲zUP!?馿gw;S(\SFBsU:)tUGA~R+ڲr[ԬċԔVj,ġǥ" Rl -% IDRUR$Q_3yuZ4\^4\h0TgaecQ`~mմHA$4ۣ'xϨ]fXF+wo.tg,S&`\4G3Nٙz7&o\o2Xl7ytR{\I1WRkʹB҅m*Oض-B9x[hH,^]$F%ZZ)Z"Ոp 錶7k M41K$}$S+@hl\jemsO4FHn= >쭋[P ޅVx"%b~M?^m.5# 2<pš,^^JԠ1j6 Rmq΋yZո]J%Y:Dae9b>Ǔw;< 3sKr3Wዣ:!( endstream endobj 2001 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.072 Tw 10 0 0 10 70.8661 359.4899 Tm [(12.0 )0.5(\(S)15(t)15(a)15(t)-34.9(S)-16(of)-28(t )0.5(Inc., )0.5(\221\234\202\). )0.6(\203\036\023\030\036\030\t\r\027\t\036 )0.5(\023\036\030\036\n\036\027\027\t\036 )]TJ 0.113 Tw 0 -1.218 TD (\023\030\036\007\f\021\026\r\035\036\027\t \n\036\007\017\026\027\024\005\ \(Me\) \017)Tj /Span<>> BDC ( )Tj EMC (\022\r\026\030\021\017\035\016\n\017 Q1 \017)Tj /Span<>> BDC ( )Tj EMC (Q3 )Tj 0.197 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\235\024\030\n\026\021\036 Me \(Q1)Tj /Span<>> BDC ( )Tj EMC (\227 Q3\). \025\026\021\036\020\024\030\017\026\035\034\027\t\036 \007\026\ \027\027\t\036 )Tj 0.283 Tw T* (\002\t\035\017 \023\030\036\007\f\021\026\r\035\036\027\t \r)Tj /Span<>> BDC ( )Tj EMC (\r\017\007\036 \026\002\f\024\035\033\021\027\024\005 \017)Tj /Span<>> BDC ( )Tj EMC (\024\021\027\024\f\017)Tj 0 Tw (-)Tj 0.254 Tw T* (\021\036\035\034\027\024\005 \004\026\f\021\024\021\t \(%\). \221\030\026\ \r\027\036\027\017\036 \027\036\023\030\036\030\t\r\027\t\b \023\024)Tj 0 Tw (-)Tj 0.124 Tw T* (\022\026\026\021\036\035\036\005 \023\024\007\020\030\031\023\023 \023\026\ \006\017\036\027\021\024\r \024\f\031\013\036\f\021\r\035\016\035\017 \f\ )Tj /Span<>> BDC ( )Tj EMC (\023\030\017)Tj 0 Tw (-)Tj 0.375 Tw T* (\n\036\027\036\027\017\036\n \022\030\017\021\036\030\017\016 \204\026\027\ \027\026\226\211\017\021\027\017, \002\017\027\024\n\017\027\026\035\034\ \027\t\036 )Tj 0.013 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC 0.682 0 Td [(\023\024\n\024\013\034\033 )0.6(\021\024\004\027\024\020\024 )0.5(\007\r\031\f\021\024\030\024\027\027\036\020\024 )0.6(\022\030\017\021\036\030\017\016 )0.5(\205\017\001\036\030\026, )]TJ 0.143 Tw -0.682 -1.218 Td (\022\030\017\021\017\004\036\f\022\017\005 \031\030\024\r\036\027\034 \027\ \026\004\017\n\024\f\021\017 )Tj /T1_1 1 Tf 0 Tw (\032)Tj /T1_0 1 Tf 0.143 Tw ( \023\030\017\027\017\n\026\035\017 \030\026\r)Tj 0 Tw (-)Tj 0.027 Tw T* [(\027\t\n )0.5(0,05. )0.5(\210\006\036\027\022\031 )0.5(\235\031\027\022\006\017\017 )0.5(\r\t\032\017\r\026\036\n\024\f\021\017 )0.6(\023\030\024\r\024\007\017\035\017 )]TJ 0.238 Tw T* (\n\036\021\024\007\024\n \025\026\023\035\026\027-\204\026\005\036\030\026\ . \215\030\017)Tj /Span<>> BDC ( )Tj EMC (\024\006\036\027\022\036 \023\030\024\020\027\024\f\021\017\004\036)Tj 0 Tw (-)Tj 0.129 Tw T* (\f\022\024\005 \027\026\004\017\n\024\f\021\017 \027\036\022\024\021\024\ \030\t\b \004\017\f\035\036\027\027\t\b \023\024\022\026\026\021\036\035\ \036\005 )Tj 0.065 Tw T* (\007\035\016 \023\030\024\020\027\024\026 \030\026\r\017\021\017\016 \030\ \036\006\017\007\017\r\026 \026\002\024\035\036\r\026\027\017\016 \021\026\ \022\032\036 )Tj 0 Tw T* (\017\f\023\024\035\034\024\r\026\035\f\016 ROC-\026\027\026\035\017.)Tj -0.074 Tw T* (\200\f\036 \030\026\f\f\n\024\021\030\036\027\027\t\036 \023\024\022\026\ \026\021\036\035\017 \017\n\036\035\017 \030\026\f\023\030\036\007\036\035\ \036\027\017\036, )Tj 0 Tw T* (\024\021\035\017\004\027\024\036 \024\021 \027\024\030\n\026\035\034\027\ \024\020\024 \(\022\030\017\021\036\030\017\005 \234\026\023\017\030\024\ -\211\017\035\022\026\).)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 70.936 140.2859 Tm [(\033\034\020)21(\223)50(\r\241)46(\024)52(\026)45(\024\232)]TJ 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0 Tc 0.417 Tw 10 0 0 10 70.8661 115.9299 Tm [(\200 )0.5(\023\024\f\035\036\024\023\036\030\026\006\017\024\027\027\024\n )0.5(\023\036\030\017\024\007\036 )0.6(\027\036\f\024\f\021\024\016\021\036\035\034\027\024\f\021\034 )]TJ 0.28 Tw T* [(\022\024\035\024\030\036\022\021\026\035\034\027\024\020\024 )0.6(\026\027\026\f\021\024\n\024\026 )0.5(\030\026\r\017\035\026\f\034 )0.6(\031)]TJ /Span<>> BDC ( )Tj EMC 18.414 0 Td (5)Tj /Span<>> BDC ( )Tj EMC 1.012 0 Td (\(5,9%\) )Tj -0.029 Tw -19.426 -1.218 Td (\002\024\035\034\027\t\b, \017)Tj /Span<>> BDC ( )Tj EMC (\027\017\b 3 \n\031\032\004\017\027 \017)Tj /Span<>> BDC ( )Tj EMC (2 \032\036\027\013\017\027\t. \221\030\036\007\027\017\005 \r\024)Tj 0 Tw (-)Tj 0.148 Tw T* (\030\026\f\021 \002\024\035\034\027\t\b \002\t\035 56,3 \020\024\007\026\ . \210\021\007\026\035\036\027\027\t\036 \n\036\021\026\f\021\026\t )Tj 0.284 Tw 23.244 64.543 Td (\035\024\022\026\035\017\024\r\026\035\017\f\034 \r)Tj /Span<>> BDC ( )Tj EMC (\023\036\004\036\027\017 \(4 \002\024\035\034\027\t\b\) \017)Tj /Span<>> BDC ( )Tj EMC (\r \035\036\020\022\017\b )Tj -0.008 Tw T* (\(1)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\034\027\024\005\). \230\030\036\n \017)Tj /Span<>> BDC ( )Tj EMC (\220\021\017\b \002\024\035\034\027\t\b \(60,0%\) \002\t\035\026 \023\030\ \024)Tj 0 Tw (-)Tj 0.045 Tw T* (\r\036\007\036\027\026 \023\030\036\007\024\023\036\030\026\006\017\024\027\ \027\026\016 \035\031\004\036\r\026\016 \021\036\030\026\023\017\016. \221\ \030\036\007\027\036\036 )Tj 0.145 Tw T* [(\030\026\f\f\021\024\016\027\017\036 )0.5(\024\021 \026\027\024\022\031\021\026\027\027\024\005 )0.5(\035\017\027\017\017 )0.5(\007\024)]TJ /Span<>> BDC ( )Tj EMC [(\024\023\031\b\024\035\017 )0.5(\002\t\035\024 )]TJ -0.046 Tw T* [(5,1 )0.5(\f\n, )0.5(\021\024 )0.5(\036\f\021\034 )0.5(\023\026\006\017\036\027\021\026\n )0.6(\r\t\023\024\035\027\036\027\t )0.5(\027\017\022\017\036 )0.6(\030\036\036\022\006\017\017 )]TJ 0.12 Tw T* (\023\030\016\n\024\005 \022\017\001\022\017. \215\024\r\021\024\030\027\t\ \036 \024\023\036\030\026\021\017\r\027\t\036 \r\n\036\001\026\021\036\035\ \034)Tj 0 Tw (-)Tj 0.02 Tw T* [(\f\021\r\026 )0.6(\023\030\017)]TJ /Span<>> BDC ( )Tj EMC 3.78 0 Td [(\220\021\024\n )0.6(\002\t\035\017 )0.6(\r\t\023\024\035\027\036\027\t )0.6(1 )0.6(\002\024\035\034\027\024\n\031 )0.6(\(G)20(r)-33(ade)]TJ /Span<>> BDC ( )Tj EMC 17.308 0 Td (\221\), )Tj 1.489 Tw -21.088 -1.218 Td (\023\024\f\035\036\024\023\036\030\026\006\017\024\027\027\026\016 \035\036\ \021\026\035\034\027\024\f\021\034 \027\026\002\035\033\007\026\035\026\f\ \034 )Tj 0.045 Tw 0 -1.218 TD (\r)Tj /Span<>> BDC ( )Tj EMC (1)Tj /Span<>> BDC ( )Tj EMC (\(1,2%\) \f\035\031\004\026\036. \223\036\021\t\030\036\n \002\024\035\034\ \027\t\n \f)Tj /Span<>> BDC ( )Tj EMC (\027\036\f\024\f\021\024\016\021\036\035\034)Tj 0 Tw (-)Tj 0.241 Tw 0 -1.218 TD (\027\024\f\021\034\033 \022\024\035\024\030\036\022\021\026\035\034\027\024\ \020\024 \026\027\026\f\021\024\n\024\026 \r)Tj /Span<>> BDC ( )Tj EMC (\007\026\035\034\027\036\005\001\036\n )Tj 0.071 Tw 0 -1.218 TD (\002\t\035\017 \r\t\023\024\035\027\036\027\t \024\023\036\030\026\021\017\ \r\027\t\036 \r\n\036\001\026\021\036\035\034\f\021\r\026 \023\024)Tj /Span<>> BDC ( )Tj EMC (\026)Tj 0 Tw (-)Tj 0.176 Tw 0 -1.218 TD (\022\030\t\021\017\033 \023\030\036\r\036\027\021\017\r\027\024\005 \017\ \035\036\024\f\021\024\n\t, \r)Tj /Span<>> BDC ( )Tj EMC (\f\030\036\007\027\036\n, \004\036\030\036 )Tj 0 Tw 0 -1.218 TD (4,5 \n\036\f\016\006\026 \023\024\f\035\036 \024\023\036\030\026\006\017\ \017.)Tj 0.1 Tw 0 -1.218 TD (\221\021\026\021\017\f\021\017\004\036\f\022\017\005 \026\027\026\035\017\  \027\036 \r\t\016\r\017\035 \027\026\004\017\n\024\005 \026\r\017\f\017\ )Tj 0 Tw (-)Tj 0.061 Tw 0 -1.218 TD [(\n\024\f\021\017 \004\026\f\021\024\021\t \030\026\r\017\021\017\016 )0.5(\027\036\f\024\f\021\024\016\021\036\035\034\027\024\f\021\017 )0.5(\022\024\035\024\030\036\022)]TJ 0 Tw (-)Tj 0.167 Tw 0 -1.218 TD (\021\026\035\034\027\024\020\024 \026\027\026\f\021\024\n\024\026 \024\021\ \007\030\031\020\017\b \022\035\017\027\017\004\036\f\022\017\b \235\026\ \022\021\024)Tj 0 Tw (-)Tj 0.255 Tw 0 -1.218 TD (\030\024\r. \215\030\017)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\n \f\026\n\026 \027\036\f\024\f\021\024\016\021\036\035\034\ \027\024\f\021\034 \026\027\026\f\021\024\n\024\026 )Tj 0 Tw 0 -1.218 TD (\027\036)Tj /Span<>> BDC ( )Tj EMC (\023\024\r\035\017\016\035\026 \027\026)Tj /Span<>> BDC ( )Tj EMC (\r\t\032\017\r\026\036\n\024\f\021\034 \023\026\006\017\036\027\021\024\r\ .)Tj 0.014 Tw 0 -1.218 TD (\210\023\036\030\026\021\017\r\027\t\036 \r\n\036\001\026\021\036\035\034\ \f\021\r\026 \023\024)Tj /Span<>> BDC ( )Tj EMC (\026\022\030\t\021\017\033 \017\035\036\024\f\021\024\n\t )Tj 0.07 Tw 0 -1.218 TD (\002\t\035\017 \r\t\023\024\035\027\036\027\t 66)Tj /Span<>> BDC ( )Tj EMC (\(78,6%\) \002\024\035\034\027\t\n, \r)Tj /Span<>> BDC ( )Tj EMC (\f\030\036\007\027\036\n \004\036)Tj 0 Tw (-)Tj 0.102 Tw T* [(\030\036 )0.5(3,6 )0.5(\n\036\f\016\006\026, )0.6(\023\030\017)]TJ /Span<>> BDC ( )Tj EMC 8.543 0 Td [(\f\030\036\007\027\036\n )0.6(\023\036\030\017\024\007\036 )0.5(\023\024\f\035\036 )0.5(\023\036\030\r\017\004)]TJ 0 Tw (-)Tj -8.543 -1.218 Td (\027\024\005 \024\023\036\030\026\006\017\017 \r)Tj /Span<>> BDC ( )Tj EMC (17,9 \n\036\f\016\006\036\r.)Tj -0.067 Tw 0 -1.218 TD (\215\026\006\017\036\027\021\t \027\026\b\024\007\017\035\017\f\034 \023\ \024\007 \027\026\002\035\033\007\036\027\017\036\n \024\021 3 \007\024)Tj /Span<>> BDC ( )Tj EMC (88)Tj /Span<>> BDC ( )Tj EMC (\n\036)Tj 0 Tw (-)Tj 0.382 Tw 0 -1.218 TD (\f\016\006\036\r. \003\026)Tj /Span<>> BDC ( )Tj EMC (\r\030\036\n\016 \027\026\002\035\033\007\036\027\017\016 \n\036\f\021\027\ \t\b \030\036\006\017\007\017\r\024\r )Tj 0.473 Tw T* (\024\023\031\b\024\035\017 \027\036 \002\t\035\024, \007\026\035\034\027\ \036\005\001\036\036 \023\030\024\020\030\036\f\f\017\030\024\r\026\027\017\ \036 )Tj 0.458 Tw 0 -1.218 TD (\n\036\021\026\f\021\026\021\017\004\036\f\022\024\020\024 \023\024\030\026\ \032\036\027\017\016 \024\021\007\026\035\036\027\027\t\b \024\030\020\026\ \027\024\r )Tj 0.075 Tw 0 -1.218 TD (\r\t\016\r\035\036\027\024 \031)Tj /Span<>> BDC ( )Tj EMC (60)Tj /Span<>> BDC ( )Tj EMC (\(71,4%\) \002\024\035\034\027\t\b \017)Tj /Span<>> BDC ( )Tj EMC (\004\026\013\036 \023\030\024\016\r\035\016\035\024\f\034 )Tj 0.137 Tw 0 -1.218 TD (\n\036\021\026\f\021\026\021\017\004\036\f\022\017\n \023\024\030\026\032\ \036\027\017\036\n \023\036\004\036\027\017)Tj /Span<>> BDC ( )Tj EMC (\227 36)Tj /Span<>> BDC ( )Tj EMC (\(42,9%\) )Tj 0.128 Tw 0 -1.218 TD (\002\024\035\034\027\t\b, \002\030\033\001\017\027\t)Tj /Span<>> BDC ( )Tj EMC (\227 16)Tj /Span<>> BDC ( )Tj EMC (\(19%\) \002\024\035\034\027\t\b, \035\036\020\022\017\b)Tj /Span<>> BDC ( )Tj EMC (\227 )Tj -0.04 Tw 0 -1.218 TD (13)Tj /Span<>> BDC ( )Tj EMC (\(15,5%\). \215\030\017)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\n \f\021\026\021\017\f\021\017\004\036\f\022\017 \027\026\004\ \017\n\024 \023\030\024\020\030\036\f)Tj 0 Tw (-)Tj 0.193 Tw 0 -1.218 TD (\f\017\030\024\r\026\027\017\036 \024\023\031\b\024\035\017 \f)Tj /Span<>> BDC ( )Tj EMC (\023\024\030\026\032\036\027\017\036\n \023\036\004\036\027\017 \017)Tj /Span<>> BDC ( )Tj EMC (\035\036\020\022\017\b )Tj 0.044 Tw T* [(\027\026\002\035\033\007\026\035\024\f\034 )0.5(\031)]TJ /Span<>> BDC ( )Tj EMC [(\002\024\035\034\027\t\b, )0.5(\022\024\021\024\030\t\n )0.5(\002\t\035 \023\030\024\r\036\007\036\027 )0.5(\022\031\030\f )]TJ 0.04 Tw T* (\023\030\036\007\024\023\036\030\026\006\017\024\027\027\024\005 \b\017\n\ \017\024\035\031\004\036\r\024\005 \021\036\030\026\023\017\017 \()Tj /T1_1 1 Tf 0 Tw (\032)Tj /T1_0 1 Tf 0.04 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,023 )Tj 0 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC /T1_1 1 Tf 0.832 0 Td (\032)Tj /T1_0 1 Tf 0.081 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,014, \f\024\024\021\r\036\021\f\021\r\036\027\027\024\). \204\036\021\026\ \f\021\026\021\017\004\036\f\022\024\036 \023\024\030\026)Tj 0 Tw (-)Tj 0.181 Tw -0.832 -1.218 Td (\032\036\027\017\036 \027\036\f\022\024\035\034\022\017\b \024\030\020\026\ \027\024\r \r)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\006\036\f\f\036 \027\026\002\035\033\007\036\027\017\016 )Tj 0.14 Tw 0 -1.218 TD [(\r\t\016\r\035\036\027\024 )0.6(\031)]TJ /Span<>> BDC ( )Tj EMC 5.179 0 Td (11)Tj /Span<>> BDC ( )Tj EMC 1.372 0 Td [(\(13,1%\) )0.6(\002\024\035\034\027\t\b, )0.6(\004\026\013\036 )0.6(\220\021\024 )0.6(\002\t\035\017 )0.6(\023\036)]TJ 0 Tw (-)Tj -6.551 -1.218 Td (\004\036\027\034 \017)Tj /Span<>> BDC ( )Tj EMC (\002\030\033\001\017\027\026 \(6 \f\035\031\004\026\036\r\).)Tj 0.353 Tw 0 -1.218 TD (\221\021\026\002\017\035\017\026\006\017\016 \024\023\031\b\024\035\036\ \r\024\020\024 \023\030\024\006\036\f\f\026 \004\026\013\036 \027\026\002\ \035\033)Tj 0 Tw (-)Tj 0.467 Tw 0 -1.218 TD (\007\026\035\026\f\034 \031)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\034\027\t\b, \022\024\021\024\030\t\036 \023\024\035\031\004\ \026\035\017 \f\017\f\021\036\n\027\031\033 )Tj 0.116 Tw 0 -1.218 TD (\b\017\n\017\024\021\036\030\026\023\017\033 \007\024)Tj /Span<>> BDC ( )Tj EMC (\017)Tj /Span<>> BDC ( )Tj EMC (\023\024\f\035\036 \024\023\036\030\026\021\017\r\027\024\020\024 \035\036\ \004\036\027\017\016)Tj /Span<>> BDC ( )Tj EMC (\227 )Tj 0.141 Tw 0 -1.218 TD (20)Tj /Span<>> BDC ( )Tj EMC (\(38,5%\) \002\024\035\034\027\t\b, \023\024)Tj /Span<>> BDC ( )Tj EMC (\f\030\026\r\027\036\027\017\033 \f)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\034\027\t\n\017, \022\024)Tj 0 Tw (-)Tj 0.072 Tw T* (\021\024\030\t\n \r)Tj /Span<>> BDC ( )Tj EMC (\022\024\n\023\035\036\022\f \035\036\004\036\027\017\016 \r\022\035\033\ \004\036\027 \017)Tj /Span<>> BDC ( )Tj EMC (\022\031\030\f \023\030\036\007\024\023\036)Tj 0 Tw (-)Tj 0.218 Tw 0 -1.218 TD (\030\026\006\017\024\027\027\024\005 \035\031\004\036\r\024\005 \021\036\ \030\026\023\017\017)Tj /Span<>> BDC ( )Tj EMC (\227 4)Tj /Span<>> BDC ( )Tj EMC (\(12,5%\) \002\024\035\034\027\t\b )Tj 0 Tw 0 -1.218 TD (\()Tj /T1_1 1 Tf (\032)Tj /T1_0 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,013\).)Tj 0.039 Tw 0 -1.218 TD (\200\f\036\020\024 \026)Tj /Span<>> BDC ( )Tj EMC (\r\030\036\n\016 \027\026\002\035\033\007\036\027\017\016 \031\n\036\030\ \035\024 57)Tj /Span<>> BDC ( )Tj EMC (\(67,9%\) \002\024\035\034)Tj 0 Tw (-)Tj -0.028 Tw 0 -1.218 TD (\027\t\b. \204\036\007\017\026\027\026 \024\002\013\036\005 \r\t\032\017\ \r\026\036\n\024\f\021\017 \023\026\006\017\036\027\021\024\r \f\024\f\021\ \026)Tj 0 Tw (-)Tj 0 -1.218 TD (\r\017\035\026 24,6 \n\036\f\016\006\036\r \(\217\017\f.)Tj /Span<>> BDC ( )Tj EMC (1\).)Tj 0.056 Tw 0 -1.218 TD [(\204\036\007\017\026\027\026 \002\036\f\f\024\002\t\021\017\005\027\024\005\ )0.5(\r\t\032\017\r\026\036\n\024\f\021\017 \002\024\035\034\027\t\b )0.5(\n\036)]TJ 0 Tw (-)Tj 0.083 Tw 0 -1.218 TD (\021\026\f\021\026\021\017\004\036\f\022\017\n \030\026\022\024\n \023\030\ \016\n\024\005 \022\017\001\022\017)Tj /Span<>> BDC ( )Tj EMC (\227 18,5)Tj /Span<>> BDC ( )Tj EMC (\n\036\f\016\006\036\r )Tj 0 Tw 0 -1.218 TD (\(\217\017\f.)Tj /Span<>> BDC ( )Tj EMC (2\).)Tj 0.048 Tw 0 -1.218 TD (\207\t\035\026 \r\t\016\r\035\036\027\026 \f\021\026\021\017\f\021\017\004\ \036\f\022\017 \027\026\004\017\n\026\016 \026\r\017\f\017\n\024\f\021\ \034 )Tj 0.043 Tw 0 -1.218 TD [(\r\t\032\017\r\026\036\n\024\f\021\017 )0.6(\023\026\006\017\036\027\021\024\r )0.5(\024\021 )0.5(\023\030\024\r\036\007\036\027\017\016 )0.6(\035\031\004\036\r\024\005 )0.5(\021\036)]TJ 0 Tw (-)Tj 0.056 Tw 0 -1.218 TD (\030\026\023\017\017 \002\024\035\034\027\t\n \n\036\021\026\f\021\026\021\ \017\004\036\f\022\017\n \030\026\022\024\n \023\030\016\n\024\005 \022\017\ \001)Tj 0 Tw (-)Tj 0.023 Tw 0 -1.218 TD (\022\017. \230\026\022, \n\036\007\017\026\027\026 \r\t\032\017\r\026\036\ \n\024\f\021\034 \002\024\035\034\027\t\b \002\036 \035\031\004\036\r\024\ \005 )Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0.176 Tw 9 0 0 9 70.8661 730.483 Tm (\020\004\206\f\t\204\004 1.)Tj 0 0 0 1 k /GS1 gs /T1_1 1 Tf ( \222\023\025\021\025\006\031\t\013\026\002 \004\026\032\026\013\024\031\ \032\025\t\024\025\013\026 \005\n\023\022\021\020\004 \032\026\013\n\003\ )Tj 0 Tw 0 -1.2 TD (\033\032\002\003\n\017 \013\025\001\013\025)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf T* [(T)48(able 1)47(.)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf [( Clinical character)-36.8(istics of patients with rectal cancer)]TJ ET 0 0 0 1 K 0.5 w /GS2 gs q 1 0 0 1 70.8661 704.381 cm 0 0 m 150.486 0 l S Q q 1 0 0 1 71.1161 673.9618 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 221.3524 704.381 cm 0 0 m 71.116 0 l S Q q 1 0 0 1 221.3524 673.9618 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 292.2185 673.9618 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 70.8661 673.7118 cm 0 0 m 150.486 0 l S Q q 1 0 0 1 71.1161 662.5005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 221.3524 673.7118 cm 0 0 m 71.116 0 l S Q q 1 0 0 1 221.3524 662.5005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 292.2185 662.5005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 662.2505 cm 0 0 m 150.486 0 l S Q q 1 0 0 1 71.1161 631.8392 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 221.3524 662.2505 cm 0 0 m 71.116 0 l S Q q 1 0 0 1 221.3524 631.8392 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 292.2185 631.8392 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 70.8661 631.5892 cm 0 0 m 150.486 0 l S Q q 1 0 0 1 71.1161 620.3779 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 221.3524 631.5892 cm 0 0 m 71.116 0 l S Q q 1 0 0 1 221.3524 620.3779 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 292.2185 620.3779 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 620.1279 cm 0 0 m 150.486 0 l S Q q 1 0 0 1 71.1161 608.9166 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 221.3524 620.1279 cm 0 0 m 71.116 0 l S Q q 1 0 0 1 221.3524 608.9166 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 292.2185 608.9166 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 608.6666 cm 0 0 m 150.486 0 l S Q q 1 0 0 1 71.1161 549.4553 cm 0 0 m 0 58.961 l S Q q 1 0 0 1 221.3524 608.6666 cm 0 0 m 71.116 0 l S Q q 1 0 0 1 221.3524 549.4553 cm 0 0 m 0 58.961 l S Q q 1 0 0 1 292.2185 549.4553 cm 0 0 m 0 58.961 l S Q q 1 0 0 1 70.8661 549.2053 cm 0 0 m 150.486 0 l S Q q 1 0 0 1 71.1161 518.7941 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 221.3524 549.2053 cm 0 0 m 71.116 0 l S Q q 1 0 0 1 221.3524 518.7941 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 292.2185 518.7941 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 70.8661 518.5441 cm 0 0 m 150.486 0 l S Q q 1 0 0 1 71.1161 478.5328 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 221.3524 518.5441 cm 0 0 m 71.116 0 l S Q q 1 0 0 1 221.3524 478.5328 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 292.2185 478.5328 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 70.8661 478.2828 cm 0 0 m 150.486 0 l S Q q 1 0 0 1 71.1161 390.2715 cm 0 0 m 0 87.761 l S Q q 1 0 0 1 221.3524 478.2828 cm 0 0 m 71.116 0 l S Q q 1 0 0 1 221.3524 390.2715 cm 0 0 m 0 87.761 l S Q q 1 0 0 1 292.2185 390.2715 cm 0 0 m 0 87.761 l S Q q 1 0 0 1 70.8661 390.0215 cm 0 0 m 150.486 0 l S Q q 1 0 0 1 221.3524 390.0215 cm 0 0 m 71.116 0 l S Q BT /GS1 gs /T1_3 1 Tf 8 0 0 8 126.2905 686.1464 Tm (\200\002\220\004\213\004\003\r\f\001)Tj -0.009 Tw 12.237 1.2 Td (\022\004\220 \212\006\235\214\002\005 \220\t\230\220\t )Tj 0 Tw 2.305 -1.2 Td (\()Tj /T1_4 1 Tf (n)Tj /T1_3 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (84\))Tj -0.001 Tw -2.305 -1.2 Td (Me \(Q1; Q3\); )Tj /T1_4 1 Tf 0 Tw (n)Tj /T1_3 1 Tf -0.001 Tw ( \(%\))Tj /T1_0 1 Tf 0 Tw -18.78 -1.433 Td (\200\024\030\026\f\021, \035\036\021)Tj 20.596 0 Td (61)Tj /Span<>> BDC ( )Tj EMC (\(55; 66\))Tj -20.596 -1.433 Td (\215\024\035:)Tj T* (\032\036\027\013\017\027\t)Tj T* (\n\031\032\004\017\027\t)Tj 20.988 1.2 Td (42)Tj /Span<>> BDC ( )Tj EMC (\(50%\))Tj T* (42)Tj /Span<>> BDC ( )Tj EMC (\(50%\))Tj -20.988 -1.433 Td (\217\026\n\036\030 \024\023\031\b\024\035\017, \f\n)Tj 20.318 0 Td (6,0)Tj /Span<>> BDC ( )Tj EMC (\(5,0; 7,0\))Tj -20.318 -1.433 Td (\217\026\f\f\021\024\016\027\017\036 \024\021 \026\027\024\022\031\021\026\ \027\027\024\005 \035\017\027\017\017, \f\n)Tj 20.068 0 Td (8,0)Tj /Span<>> BDC ( )Tj EMC (\(7,0; 10,0\))Tj -20.068 -1.433 Td (\fT2)Tj 0 -1.2 TD (\fT3)Tj 0 -1.2 TD (\fT4\026)Tj 0 -1.2 TD (\fN0)Tj 0 -1.2 TD (\fN1)Tj 0 -1.2 TD (\fN2)Tj 21.146 6 Td (3)Tj /Span<>> BDC ( )Tj EMC (\(3,6%\))Tj -0.5 -1.2 Td (54)Tj /Span<>> BDC ( )Tj EMC (\(64,3%\))Tj 0 -1.2 TD (27)Tj /Span<>> BDC ( )Tj EMC (\(32,1%\))Tj 0.5 -1.2 Td (5)Tj /Span<>> BDC ( )Tj EMC (\(7,1%\))Tj -0.5 -1.2 Td (41)Tj /Span<>> BDC ( )Tj EMC (\(48,8%\))Tj 0 -1.2 TD (37)Tj /Span<>> BDC ( )Tj EMC (\(44,1%\))Tj -20.646 -1.433 Td (\215\030\036\007\024\023\036\030\026\006\017\024\027\027\024\036 \035\036\ \004\036\027\017\036:)Tj T* (\216\214\230)Tj T* (\215\216\230)Tj 20.988 1.2 Td (16)Tj /Span<>> BDC ( )Tj EMC (\(19%\))Tj T* (68)Tj /Span<>> BDC ( )Tj EMC (\(81%\))Tj -20.988 -1.433 Td (\221\021\036\023\036\027\034 \007\017\235\235\036\030\036\027\006\017\030\ \024\r\022\017:)Tj T* (G1)Tj T* (G2)Tj 0 -1.2 TD (G3-4)Tj 21.146 2.4 Td (6)Tj /Span<>> BDC ( )Tj EMC (\(7,1%\))Tj -0.5 -1.2 Td (67)Tj /Span<>> BDC ( )Tj EMC (\(79,8%\))Tj T* (11)Tj /Span<>> BDC ( )Tj EMC (\(13,1%\))Tj -20.646 -1.433 Td (\214\024\022\026\035\017\026\006\017\017 \024\021\007\026\035\036\027\027\ \t\b \n\036\021\026\f\021\026\024\r )Tj 0 -1.2 TD (\007\024)Tj /Span<>> BDC ( )Tj EMC (\035\036\004\036\027\017\016:)Tj T* (\023\036\004\036\027\034)Tj T* (\035\036\020\022\017\036)Tj T* (\027\036\030\036\020\017\024\027\026\030\027\t\036 \035\017\n\235\024\031\ \035\t)Tj T* (\002\030\033\001\017\027\026)Tj T* (\020\024\035\024\r\027\024\005 \n\024\020)Tj T* (\016\017\004\027\017\022\017)Tj T* (\027\026\007\023\024\004\036\004\027\017\022)Tj 20.646 7.2 Td (62)Tj /Span<>> BDC ( )Tj EMC (\(73,8%\))Tj T* (18)Tj /Span<>> BDC ( )Tj EMC (\(21,4%\))Tj 0.5 -1.2 Td (2)Tj /Span<>> BDC ( )Tj EMC (\(2,4%\))Tj -0.5 -1.2 Td (10)Tj /Span<>> BDC ( )Tj EMC (\(11,9%\))Tj 0.5 -1.2 Td (1)Tj /Span<>> BDC ( )Tj EMC (\(1,2%\))Tj T* (4)Tj /Span<>> BDC ( )Tj EMC (\(4,8%\))Tj T* (2)Tj /Span<>> BDC ( )Tj EMC (\(2,4%\))Tj 1 0.68 0 0.12 k /GS0 gs /T1_5 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\033\030\031\030\213\b)-20.9(\035\231\213\233\t \021\032)50(\b)42(\032\231\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj -51.938 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 23, \023\0221)69(, 202)69(4)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 23, \023\0221)69(, 202)69(4)]TJ /T1_6 1 Tf 25 0 0 25 28.1402 56.0378 Tm (54)Tj ET endstream endobj 2000 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\033\016\222)21(\215\007\216)21(\026)11(\013\026\020 \002\016\222\016\n\227\220\220 \221\002\205\024\025\203 \n\220\ \n\220 \221\002\220\022\024\016\026)11(\013\006)-10(\026)11(\013\026\220\017\016\006\n)10(\025\024\022\002\013\n\016)]TJ 42.522 0 Td [(Results of r)31(ectal r)31(esection in metastatic cancer)]TJ ET 0 0 0 1 K 1 j 1 J [0 2.997]0 d /GS1 gs q 1 0 0 1 46.0167 706.8466 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 43.0197 706.8466 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q [0 2.997]0 d q 1 0 0 1 46.0167 669.6388 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 43.0197 669.6388 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q 0 j 0 J q 1 0 0 1 42.5197 605.9696 cm 0 0 m 453.543 0 l S Q BT 0 0 0 1 k /T1_1 1 Tf 0.01 Tc -0.01 Tw 8 0 0 8 42.5596 731.2159 Tm [(KEYW)22(ORDS:)]TJ /T1_2 1 Tf 0 Tc 0.023 Tw 4.948 0 Td [( rectal resection, metastatic rectal cancer)61.1(, anastomosis failure, distant metastases, p)45.9(rev)13(entiv)13.1(e intestinal stoma)]TJ /T1_1 1 Tf 0.01 Tc 0.018 Tw -4.948 -1.909 Td [(C)19(ONFL)-33(ICT)5( OF)5( INTE)25(REST)62(:)]TJ /T1_2 1 Tf 0 Tc 0.023 Tw 9.871 0 Td [( The authors declare no conf)-22(lict of interest)]TJ /T1_1 1 Tf 0.015 Tc -0.044 Tw -9.871 -2.617 Td [(F)3.3(O)-4.5(R)8.8( C)-17.4(I)-15.5(T)45.5(A)37.5(T)-24.4(I)-1.2(ON:)]TJ /T1_3 1 Tf 0.001 Tc -0.035 Tw 6.114 0 Td [( K)-18.1(i)-15.7(t)]TJ /Span<>> BDC ( )Tj EMC [(O)11.4(.)-9.7(I)-10.2(.)-23.4(, G)-18.4(e)-15.7(v)-15.3(o)-11.7(r)-30.7(k)-45.6(y)-24.1(a)-7.5(n)]TJ /Span<>> BDC ( )Tj EMC [(Y)12.7(u)-8.9(.)-23.8(A)-22.9(.)-23.4(, S)-25.1(o)-15.5(l)-25(d)-9.2(a)-18.2(t)-28.3(k)-41(i)-3.1(n)-7.7(a)]TJ /Span<>> BDC ( )Tj EMC [(N)-2.7(.)40.7(V)39.8(.)-23.4(, K)-11.1(o)-15.5(l)-23.6(e)-22.7(s)-6.5(n)-14(i)-6.5(k)-3.6(o)-10.2(v)]TJ /Span<>> BDC ( )Tj EMC [(E)-5.6(.)-1.8(N)-2.7(.)-23.4(, G)-11.2(u)-21.8(s)-24.6(a)-10.1(r)-19(e)-15.7(v)-28.3(a)]TJ /Span<>> BDC ( )Tj EMC [(M)-7(.)-23.8(A)-22.9(.)-23.4(, B)-14.8(o)-9.1(n)-14.4(d)-9.2(a)-10.1(r)-19(e)-11.5(n)-8.7(k)-3.6(o)]TJ /Span<>> BDC ( )Tj EMC [(O)11.5(.K)-26.9(.)-23.4(, A)-12.5(n)-13.9(i)-7.3(s)-26(i)-3.1(m)-12.3(o)-10.2(v)]TJ /Span<>> BDC ( )Tj EMC [(A)-22.9(.)0.5(E)-5.5(.)-23.4(, V)-20.9(l)-37.7(a)-12.9(d)-15.7(i)-3.1(m)-14.5(i)-5.9(r)-15.7(o)-10.2(v)-28.3(a L)-29.4(.)51.7(Y)12.7(u)-8.9(.)1( )]TJ -0.001 Tc -0.036 Tw -6.119 -1.2 Td [(R)-6.7(e)-22.7(s)-8.8(u)-8.4(l)-15.4(t)-48.8(s )0.5(o)-12.1(f )0.5(r)-19(e)-19.1(c)-41.5(t)-36.7(a)-11.4(l )0.5(r)-19.1(e)-22.8(s)-22.8(e)-19.1(c)-41.5(t)-46.1(i)-6.8(o)-9.2(n )0.5(i)-3.2(n )0.5(m)-16.6(e)-22.3(t)-36.7(a)-26.6(s)-29.3(t)-36.8(a)-18.2(t)-46.1(i)-5(c )0.5(c)-21.4(a)-7.6(n)-10(c)-9.7(e)-12.1(r)30.7(. )]TJ /T1_2 1 Tf 0.009 Tc -0.009 Tw 19.777 0 Td [(K)13.9(ol)3.6(op)2.4(r)3.1(o)3.5(k)-19.2(t)2.2(ol)3.6(o)-3.2(g)-13.2(i)6.7(a)5.9(.)]TJ /T1_3 1 Tf -0.001 Tc -0.036 Tw 6.635 0 Td [( )0.5(2)-8.9(0)-3.8(2)8.9(4)10.2(;)9.8(2)-10.3(3)6.1(\()37.7(1)44.3(\))14.5(:)4.1(5)4.8(2)9.8(\226)-8.4(5)-19.6(8)-11.1(. )0.5(\()-0.9(i)-3.2(n )0.5(R)-6.4(u)-21.9(s)-22.3(s)-15.5(.)43.3(\))10.4(. )0.5(h)-17.2(t)-49.3(t)-29.4(p)-18.7(s)-8(:)2(/)84.7(/)36.4(d)-11(o)-12.5(i.)2.7(o)-11.7(r)-16.7(g)-22.8(/)11.2(1)14(0)6.6(.)-5.6(3)7.9(3)-15.9(8)1.3(7)4.7(8/)7.9(2)-8.9(0)9.4(7)-1.9(3)-13.3(-)41.2(7)10.7(5)0.5(5)-8.9(6)-26.7(-)9.7(2)-8.9(0)-3.7(2)8.8(4)-28.5(-)]TJ 0.031 Tc -0.031 Tw -26.412 -1.2 Td [(2)-2.3(3)-5.3(-)63.1(1)34.9(-5)12.7(2)20.1(-5)-11.6(8)]TJ /T1_1 1 Tf 0.01 Tc -0.016 Tw 0.005 -2.617 Td [(\026\020\021\033\030)5( \020\036\017)5( \013\033\021\033\013\023\030\037\023:)]TJ /T1_2 1 Tf 0 Tc -0.011 Tw 10.509 0 Td ( \207\n\023\030\026\024\013\025\021\026 \217\026\024\026\023\022\002 \216\ \026\t\025\023\022\031\027\021\026, \225\210\213\214 \253\217\240\215\037\ \n\021\013\n\023\n\202\025\025\273 \240\025\021\016\030\032\026\027\026\ \212\n\t\t\025\025, \205\023.)Tj /Span<>> BDC ( )Tj EMC (14-\002 \023\025\021\025\002, \030.)Tj /Span<>> BDC ( )Tj EMC (63, \212\n\t\024\n\027-\021\026-)Tj 0.023 Tw -10.514 -1.2 Td (\200\n\021\205, 344037, \212\n\t\t\025\002; \024\031\023. 8-918-545-3004\ ; e-mail: snv-rnioi@yandex.ru)Tj /T1_1 1 Tf 0.01 Tc 0.234 Tw 0.005 -1.2 Td [(ADDRESS)4.9( F)13(OR)5( C)19(ORRESPONDEN)23(CE:)]TJ /T1_2 1 Tf 0 Tc 0.239 Tw 14.483 0 Td [( Sold)26.1(atkina N)28(.V)61(., F)11(ederal S)28(tate Budg)12(etar)-43(y Institution \236N)18(ational Medical R)21(esearch Center of Oncology\237 )]TJ 0.199 Tw -14.488 -1.2 Td [(of the Ministr)-43(y of Health of the R)22(ussian F)11(ederation; )0.5(str)51(. 14th line, 63, R)19(ostov-on-Don, 344037, R)22(ussia; tel.: +7 \(918\) 545-30-04; e-mail: )]TJ 0 Tw 0 -1.2 TD [(sn)11(v-r)-14(nioi@yande)-14.9(x.ru)]TJ 0 -2.792 TD (\200\026\024\026 \033\n\t\024\205\033\023\031\021\025\002)Tj /Span<>> BDC ( )Tj EMC (\227 30.06.2023)Tj /Span<>> BDC ( )Tj EMC 19.488 0 Td (\n\t\023\031 \030\n\032\026\005\n\024\013\025)Tj /Span<>> BDC ( )Tj EMC (\227 21.07.2023)Tj /Span<>> BDC ( )Tj EMC 18.78 0 Td (\032\025\021\002\024\n \013)Tj /Span<>> BDC ( )Tj EMC (\033\205\005\023\025\013\026\203\025\025)Tj /Span<>> BDC ( )Tj EMC (\227 12.02.2024)Tj ( )Tj -38.268 -1.375 Td (Received)Tj /Span<>> BDC ( )Tj EMC (\227 30.06.2023)Tj /Span<>> BDC ( )Tj EMC 19.488 0 Td (Revised)Tj /Span<>> BDC ( )Tj EMC (\227 21.07.2023)Tj /Span<>> BDC ( )Tj EMC 18.78 0 Td (Accepted for publication)Tj /Span<>> BDC ( )Tj EMC (\227 12.02.2024)Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 42.5896 542.1599 Tm (\023\023\034\226\034\022\031\034)Tj 0 0 0 1 k /GS1 gs /T1_3 1 Tf 0 Tc 0.078 Tw 10 0 0 10 42.5197 517.8039 Tm (\217\026\022 \023\030\016\n\024\005 \022\017\001\022\017)Tj /Span<>> BDC ( )Tj EMC (\227 \030\026\f\023\030\024\f\021\030\026\027\036\027\027\026\016 \r)Tj /Span<>> BDC ( )Tj EMC (\f\021\030\031\022\021\031\030\036 )Tj 0.001 Tw 0 -1.218 TD (\024\027\022\024\035\024\020\017\004\036\f\022\024\005 \026\002\024\035\ \036\r\026\036\n\024\f\021\017 \024\023\031\b\024\035\034 \f)Tj /Span<>> BDC ( )Tj EMC (\r\t\f\024\022\017\n\017 )Tj 0.18 Tw T* (\023\024\022\026\026\021\036\035\016\n\017 \f\n\036\030\021\027\024\f\021\ \017 [1,2]. \215\030\017)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\n \027\026\017\002\024\035\036\036 )Tj 0.163 Tw T* (\004\026\f\021\024\005 \023\030\017\004\017\027\024\005 \016\r\035\016\036\ \021\f\016 \027\026\035\017\004\017\036 \024\021\007\026\035\201\027\027\ \t\b \n\036)Tj 0 Tw (-)Tj 0.092 Tw T* (\021\026\f\021\026\024\r, \004\026\013\036 \n\036\021\026\b\030\024\027\ \027\t\b ~ 40% \017)Tj /Span<>> BDC ( )Tj EMC (\030\036\032\036 \f\017\027\b\030\024\027)Tj 0 Tw (-)Tj 0.3 Tw T* (\027\t\b)Tj /Span<>> BDC ( )Tj EMC (\227 25%, \023\024\f\035\036\007\027\017\036 \026\f\f\024\006\017\017\030\ \024\r\026\027\t \f)Tj /Span<>> BDC ( )Tj EMC (\b\031\007\001\017\n )Tj 0.068 Tw T* (\023\030\024\020\027\024\024\n. \207\024\035\036\036 \023\024\035\024\r\ \017\027\t \023\026\006\017\036\027\021\024\r \n\036\021\026\f\021\026\021\ \017\004\036)Tj 0 Tw (-)Tj 0.219 Tw T* (\f\022\017\n \022\024\035\024\030\036\022\021\026\035\034\027\t\n \030\026\ \022\024\n \017\n\036\033\021 \027\036\030\036\036\022\021\026\002\036\035\ \034)Tj 0 Tw (-)Tj 0.018 Tw T* [(\027\024\036 \n\036\021\026\f\021\026\021\017\004\036\f\022\024\036 )0.5(\023\024\030\026\032\036\027\017\036 \024\021\007\026\035\036\027\027\t\b\ )0.5(\024\030\020\026\027\024\r )]TJ 0 Tw T* ([3,4].)Tj -0.003 Tw T* (\200 \f\r\016\017 \f)Tj /Span<>> BDC ( )Tj EMC (\023\024\016\r\035\036\027\017\036\n \220\235\235\036\022\021\017\r\027\t\ \b \f\b\036\n \023\024\035\017\b\017\n\017\024)Tj /Span<>> BDC (-)Tj EMC 0.368 Tw T* (\021\036\030\026\023\017\017, \023\030\017\n\036\027\036\027\017\036\n \021\ \026\030\020\036\021\027\024\005 \021\036\030\026\023\017\017, \030\026\f\ \001\017)Tj 0 Tw (-)Tj 0.27 Tw T* (\030\036\027\017\036\n \023\024\022\026\026\027\017\005 \007\035\016 \024\ \023\036\030\026\021\017\r\027\t\b \r\n\036\001\026\021\036\035\034\f\021\ \r, )Tj 0.313 Tw T* (\023\030\024\020\027\024 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\n\036\021\026\f\021\026\021\017\004\036\f\022\024\n \030\026\022\036 \023\ \030\016\n\024\005 \022\017\001\022\017 )Tj 0 Tw T* (\027\026\004\017\021\036\035\034\027\024 \031\035\031\004\001\017\035\f\ \016 [1,2,5,6].)Tj 0.01 Tw T* (\200 \027\026\f\021\024\016\013\036\036 \r\030\036\n\016 \002\024\035\034\ \027\t\036 \f)Tj /Span<>> BDC ( )Tj EMC (\023\024\021\036\027\006\017\026\035\034\027\024 \030\036\036\022\021\026\ )Tj 0 Tw (-)Tj 0.064 Tw T* [(\002\036\035\034\027\t\n\017 \n\036\021\026\f\021\026\026\n\017 )0.5(\007\024\035\032\027\t \023\024\035\031\004\026\021\034 \n\026\022\f\017\ \n\026\035\034)]TJ 0 Tw (-)Tj 0.019 Tw T* (\027\024 \220\235\235\036\022\021\017\r\027\031\033 \035\036\022\026\030\ \f\021\r\036\027\027\031\033 \021\036\030\026\023\017\033 \017)Tj /Span<>> BDC ( )Tj EMC (\024\023\036\030\017\030\024)Tj 0 Tw (-)Tj 0.22 Tw T* (\r\026\021\034\f\016 \022\026\022 \021\024\035\034\022\024 \023\030\024\006\ \036\f\f \f\021\026\027\036\021 \030\036\036\022\021\026\002\036\035\034\ \027\t\n. )Tj 0.303 Tw T* (\211)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\027\036\030\036\036\022\021\026\002\036\035\034\027\t\n \n\036\021\026\ \f\021\026\021\017\004\036\f\022\017\n )Tj -0.015 Tw T* [(\023\030\024\006\036\f\f\024\n \b\017\030\031\030\020\017\004\036\f\022\024\ \036 )0.5(\r\n\036\001\026\021\036\035\034\f\021\r\024 \n\024\032\036\021 \002\t\021\ \034 )]TJ 0 Tw T* (\220\021\026\023\024\n \022\024\n\023\035\036\022\f\027\024\020\024 \035\ \036\004\036\027\017\016 [7].)Tj 0.268 Tw T* [(\212\026\027\027\026\016 )0.6(\f\021\026\021\034\016 )0.5(\023\024\f\r\016\013\036\027\026 )0.6(\024\006\036\027\022\036 )0.5(\f\024\002\f\021\r\036\027\027\t\b )0.6(\030\036)]TJ 0 Tw (-)Tj 0.107 Tw T* [(\031\035\034\021\026\021\024\r )0.6(\030\036\036\022\006\017\017 )0.5(\023\030\016\n\024\005 )0.5(\022\017\001\022\017 )0.5(\023\030\017)]TJ /Span<>> BDC ( )Tj EMC 16.762 0 Td (\n\036\021\026\f\021\026\021\017\004\036)Tj 0 Tw (-)Tj -16.762 -1.218 Td (\f\022\024\n \030\026\022\036 \023\030\016\n\024\005 \022\017\001\022\017\ .)Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 0.01 Tc 0.018 Tw 14 0 0 14 42.5896 188.9979 Tm [(\f\026\017\031\034\022\024\232)5( \031)5(\016)-18.3(\240\034)-31(\024)35(\037\226\232)]TJ 0 0 0 1 k /GS1 gs /T1_3 1 Tf 0 Tc 0.249 Tw 10 0 0 10 42.5197 164.6418 Tm (\215\030\024\r\036\007\036\027 \026\027\026\035\017 \030\036\031\035\034\ \021\026\021\024\r \035\036\004\036\027\017\016 84 \002\024\035\034\027\t\ \b )Tj 0.265 Tw T* (\f\017\n\023\021\024\n\027\t\n \030\036\036\022\021\026\002\036\035\034\ \027\t\n \030\026\022\024\n \023\030\016\n\024\005 \022\017\001\022\017 \ )Tj 0.192 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\027\026\035\017\004\017\036\n \027\036\030\036\036\022\021\026\002\036\ \035\034\027\t\b \024\021\007\026\035\036\027\027\t\b \n\036\021\026\f\021\ \026)Tj 0 Tw (-)Tj 0.052 Tw T* [(\024\r )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 2.488 0 Td [(\f\021\026\007\017\036\005 )0.6(\026\002\024\035\036\r\026\027\017\016 )0.5(\024\021 )0.6(\fT2N0M1 )0.5(\007\024)]TJ /Span<>> BDC ( )Tj EMC 15.505 0 Td (\fT4\026N2M1 )Tj 0.226 Tw -17.993 -1.218 Td (\(\230\026\002\035.)Tj /Span<>> BDC ( )Tj EMC (1\), \023\024\035\031\004\026\r\001\017\b \035\036\004\036\027\017\036 \f\ )Tj /Span<>> BDC ( )Tj EMC (2015 \023\024)Tj /Span<>> BDC ( )Tj EMC (2020 \020\020. )Tj 0.038 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\205\206\207\211 \253\203\204\222\037 \024\027\022\024\035\024\020\017\017\ \273 \204\003 \217\205. \204\036\007\017\026\027\026 \r\024\030\026\f\021\ \026 )Tj 0.005 Tw T* [(\002\024\035\034\027\t\b )0.5(\f\024\f\021\026\r\017\035\026 )0.5(60,3 \(22\22682\) \020\024\007\026. )0.5(\221\030\036\007\017 \002\024\035\034\027\t\b )]TJ 0.197 Tw T* (\002\t\035\024 \030\026\r\027\024\036 \022\024\035\017\004\036\f\021\r\024\ \n\031\032\004\017\027 \017)Tj /Span<>> BDC ( )Tj EMC (\032\036\027\013\017\027 \(\023\024)Tj /Span<>> BDC ( )Tj EMC (42 )Tj -0.044 Tw 23.244 47.494 Td (\023\026\006\017\036\027\021\026\). \215\036\030\r\017\004\027\t\036 \024\ \023\031\b\024\035\017 \023\030\016\n\024\005 \022\017\001\022\017 \r\024\ \r\f\036\b )Tj 0.087 Tw T* (\f\035\031\004\026\016\b \017\n\036\035\017 \f\017\n\023\021\024\n\027\t\ \005 \b\026\030\026\022\021\036\030 \(\022\030\024\r\024\021\036\004\036\ \027\017\036, )Tj 0.521 Tw T* (\f\031\002\022\024\n\023\036\027\f\017\030\024\r\026\027\027\026\016 \022\ \017\001\036\004\027\026\016 \027\036\023\030\024\b\024\007\017\n\024\f\021\ \034\), )Tj 0.303 Tw T* (\027\024 \027\036 \r\024\r\035\036\022\026\035\017 \r)Tj /Span<>> BDC ( )Tj EMC (\024\023\031\b\024\035\036\r\t\005 \023\030\024\006\036\f\f \f\024\f\036\ \007\027\017\036 )Tj 0 Tw T* (\024\030\020\026\027\t.)Tj 0.303 Tw T* (\206\017\f\021\024\035\024\020\017\004\036\f\022\017 \031)Tj /Span<>> BDC ( )Tj EMC (\r\f\036\b \002\024\035\034\027\t\b \002\t\035\026 \031\f\021\026\027\024\ \r\035\036\027\026 )Tj 0.381 Tw T* (\026\007\036\027\024\022\026\030\006\017\027\024\n\026 \030\026\035\017\ \004\027\024\005 \f\021\036\023\036\027\017 \007\017\235\235\036\030\036\ \027\006\017)Tj 0 Tw (-)Tj -0.062 Tw T* (\030\024\r\022\017 \f)Tj /Span<>> BDC ( )Tj EMC (\023\030\036\024\002\035\026\007\026\027\017\036\n \031\n\036\030\036\027\ \027\024 \007\017\235\235\036\030\036\027\006\017\030\024\r\026\027)Tj 0 Tw (-)Tj 0.037 Tw T* (\027\024\005)Tj /Span<>> BDC ( )Tj EMC (\227 67)Tj /Span<>> BDC ( )Tj EMC (\(79,8%\) \002\024\035\034\027\t\b. \204\036\007\017\026\027\026 \030\026\ \n\036\030\026 \024\023\031\b\024)Tj 0 Tw (-)Tj 0.006 Tw T* (\035\017 \f\024\f\021\026\r\017\035\026 6,0 \(5,0; 7,0\) \f\n. \204\036\007\ \017\026\027\026 \030\026\f\f\021\024\016\027\017\036 \024\021 )Tj 0.06 Tw T* (\026\027\024\022\031\021\026\027\027\024\005 \035\017\027\017\017 \007\024\ )Tj /Span<>> BDC ( )Tj EMC (\024\023\031\b\024\035\017 \023\030\016\n\024\005 \022\017\001\022\017)Tj /Span<>> BDC ( )Tj EMC (\227 8,0 )Tj -0.014 Tw T* (\(7,0; 10,0\) \f\n. \207\024\035\034\001\017\027\f\021\r\024 \002\024\035\ \034\027\t\b)Tj /Span<>> BDC ( )Tj EMC (\227 52)Tj /Span<>> BDC ( )Tj EMC (\(61,9%\))Tj /Span<>> BDC ( )Tj EMC (\227 )Tj 0.146 Tw T* (\017\n\036\035\017 \f\021\026\007\017\033 \026\002\024\035\036\r\026\027\ \017\016 T3N1-2M1. \211)Tj /Span<>> BDC ( )Tj EMC (62)Tj /Span<>> BDC ( )Tj EMC (\(73,8%\) )Tj 0.459 Tw T* (\002\024\035\034\027\t\b \024\021\007\026\035\036\027\027\t\036 \n\036\021\ \026\f\021\026\t \007\024)Tj /Span<>> BDC ( )Tj EMC (\027\026\004\026\035\026 \035\036\004\036)Tj 0 Tw (-)Tj 0.12 Tw T* (\027\017\016 \035\024\022\026\035\017\024\r\026\035\017\f\034 \r)Tj /Span<>> BDC ( )Tj EMC (\023\036\004\036\027\017, \035\036\020\022\017\b)Tj /Span<>> BDC ( )Tj EMC (\227 18)Tj /Span<>> BDC ( )Tj EMC (\(21,4%\) )Tj 0.051 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC 0.801 0 Td (\002\030\033\001\017\027\036)Tj /Span<>> BDC ( )Tj EMC 4.132 0 Td [(\227 )0.5(10)]TJ /Span<>> BDC ( )Tj EMC 2.567 0 Td [(\(11,9%\). )0.5(\211)]TJ /Span<>> BDC ( )Tj EMC 4.541 0 Td (71)Tj /Span<>> BDC ( )Tj EMC 1.284 0 Td [(\(84,5%\) )0.5(\002\024\035\034\027\024\020\024 )0.6(\024\021)]TJ 0 Tw (-)Tj 0.012 Tw -13.325 -1.218 Td (\007\026\035\036\027\027\t\036 \n\036\021\026\f\021\026\t \035\024\022\026\ \035\017\024\r\026\035\017\f\034 \r)Tj /Span<>> BDC ( )Tj EMC (\024\007\027\024\n \024\030\020\026\027\036, )Tj 0.032 Tw T* (\031)Tj /Span<>> BDC ( )Tj EMC 0.709 0 Td [(\024\f\021\026\035\034\027\t\b )0.6(\023\026\006\017\036\027\021\024\r)]TJ /Span<>> BDC ( )Tj EMC 9.117 0 Td [(\227 )0.5(\024\007\027\024\r\030\036\n\036\027\027\024 )0.6(\r)]TJ /Span<>> BDC ( )Tj EMC 8.276 0 Td (2\2263)Tj /Span<>> BDC ( )Tj EMC 1.82 0 Td (\024\030\020\026)Tj 0 Tw (-)Tj 0.157 Tw -19.923 -1.218 Td (\027\026\b. \215\030\017)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\n \004\026\013\036 \r\f\036\020\024 \024\007\027\024\r\030\036\ \n\036\027\027\024 \n\036\021\026\f\021\026\t )Tj 0 Tw T* (\027\026\002\035\033\007\026\035\017\f\034 \r)Tj /Span<>> BDC ( )Tj EMC (\023\036\004\036\027\017 \017)Tj /Span<>> BDC ( )Tj EMC (\035\036\020\022\017\b \()Tj /T1_2 1 Tf (n)Tj /T1_3 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (4\).)Tj 0.367 Tw T* (\215\030\036\007\024\023\036\030\026\006\017\024\027\027\026\016 \023\030\ \024\035\024\027\020\017\030\024\r\026\027\027\026\016 \022\024\027\235\024\ \030\n\027\026\016 )Tj 0.345 Tw T* [(\035\031\004\036\r\026\016 \021\036\030\026\023\017\016 )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC (\030\026\007\017\024\n\024\007\017\235\017\022\026\006\017\036\005 \022\026\ \023\036\006\017\021\026)Tj 0 Tw (-)Tj 0.303 Tw T* (\002\017\027\024\n \023\030\024\r\036\007\036\027\026 16)Tj /Span<>> BDC ( )Tj EMC (\(19,0%\) \002\024\035\034\027\t\n. \210\f\021\026\035\034\027\t\036 )Tj 0.032 Tw T* [(\002\024\035\034\027\t\036 )0.5(\023\024\035\031\004\017\035\017 )0.6(3\2264)]TJ /Span<>> BDC ( )Tj EMC 9.766 0 Td [(\022\031\030\f\026 )0.5(\023\030\036\007\024\023\036\030\026\006\017\024\027\027\024\005 )0.6(\215\216\230 )]TJ 0.236 Tw -9.766 -1.218 Td [(\(\023\024 \f\b\036\n\036 FOLFO)17.1(X\) \f)]TJ /Span<>> BDC ( )Tj EMC (\023\030\017\n\036\027\036\027\017\036\n \021\026\030\020\036\021\027\024\ \005 \021\036\030\026)Tj 0 Tw (-)Tj 0.069 Tw T* (\023\017\017 \r)Tj /Span<>> BDC ( )Tj EMC (\026\r\017\f\017\n\024\f\021\017 \024\021 \n\031\021\026\006\017\024\027\ \027\024\020\024 \f\021\026\021\031\f\026 \024\023\031\b\024\035\017 )Tj -0.027 Tw T* (\(54)Tj /Span<>> BDC ( )Tj EMC (\(64%\) \002\024\035\034\027\t\b \f)Tj /Span<>> BDC ( )Tj EMC (\007\017\022\017\n \021\017\023\024\n \020\036\027\026 )Tj /T1_2 1 Tf 0 Tw [(KRA)50(S)]TJ /T1_3 1 Tf -0.027 Tw ( \023\024\035\031\004\026\035\017 )Tj -0.036 Tw T* (\017\027\020\017\002\017\021\024\030\t EGFR, 30)Tj /Span<>> BDC ( )Tj EMC (\(36%\) \002\024\035\034\027\t\b \f)Tj /Span<>> BDC ( )Tj EMC (\027\026\035\017\004\017\036\n \n\031\021\026)Tj 0 Tw (-)Tj T* (\006\017\005 \020\036\027\026 )Tj /T1_2 1 Tf [(KRA)50(S)]TJ /T1_3 1 Tf ( \023\024\035\031\004\026\035\017 \002\036\r\026\006\017\031\n\026\002\)\ .)Tj 0.21 Tw 0 -1.218 TD (\200\f\036\n \002\024\035\034\027\t\n \r\t\023\024\035\027\036\027\026 \027\ \017\022\026\016 \030\036\036\022\006\017\016 \023\030\016\n\024\005 )Tj 0.057 Tw 0 -1.218 TD (\022\017\001\022\017 \f)Tj /Span<>> BDC ( )Tj EMC (\n\036\024\030\036\022\021\031\n\220\022\021\024\n\017\036\005, \235\024\ \030\n\017\030\024\r\026\027\017\036\n \022\024\035\024)Tj 0 Tw (-)Tj 0.073 Tw 0 -1.218 TD (\030\036\022\021\026\035\034\027\024\020\024 \026\027\026\f\021\024\n\024\ \026 \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\036\r\036\027\021\017\r\027\024\005 \017\035\036\024\f\021\024\n\ \t. )Tj 0.277 Tw T* (\200)Tj /Span<>> BDC ( )Tj EMC (\023\024\f\035\036\007\031\033\013\036\n \r\t\023\024\035\027\016\035\017\ \f\034 \024\023\036\030\026\021\017\r\027\t\036 \r\n\036\001\026)Tj 0 Tw (-)Tj T* (\021\036\035\034\f\021\r\026 \023\024)Tj /Span<>> BDC ( )Tj EMC (\026\022\030\t\021\017\033 \017\035\036\024\f\021\024\n\t.)Tj 0.398 Tw T* (\215\024\f\035\036 \026\r\036\030\001\036\027\017\016 \b\017\030\031\030\ \020\017\004\036\f\022\024\020\024 \220\021\026\023\026 \035\036\004\036\ \027\017\016 )Tj 0.317 Tw T* [(\002\024\035\034\027\t\036 )0.6(\023\024\035\031\004\026\035\017 )0.5(\n\027\024\020\024\022\031\030\f\024\r\031\033 )0.6(\023\024\035\017\b\017\n\017\024\021\036\030\026)]TJ 0 Tw (-)Tj -0.008 Tw T* (\023\017\033, \021\026\030\020\036\021\027\031\033 \021\036\030\026\023\017\ \033 \017)Tj /Span<>> BDC ( )Tj EMC (\027\026\b\024\007\017\035\017\f\034 \023\024\007 \007\017\027\026\n\017\ \004\036)Tj 0 Tw (-)Tj T* (\f\022\017\n \027\026\002\035\033\007\036\027\017\036\n.)Tj 0.053 Tw T* [(\221\021\026\021\017\f\021\017\004\036\f\022\026\016 )0.6(\024\002\030\026\002\024\021\022\026 )0.5(\007\026\027\027\t\b )0.6(\023\030\024\r\024\007\017\035\026\f\034 )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC 20.803 0 Td (\017\f)Tj 0 Tw (-)Tj 0.503 Tw -20.803 -1.218 Td [(\023\024\035\034\024\r\026\027\017\036\n )0.6(\f\021\026\021\017\f\021\017\004\036\f\022\024\020\024 )0.5(\023\026\022\036\021\026 )0.5(S)-20.9(T)34.9(A)15.1(TIS)-21(TIC)20(A )]TJ 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 0 Tw 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\033\030\031\030\213\b)-20.9(\035\231\213\233\t \021\032)50(\b)42(\032\231\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj /T1_5 1 Tf 25 0 0 25 512.7645 56.0378 Tm (53)Tj ET endstream endobj 1997 0 obj [2055 0 R] endobj 1998 0 obj <>stream q /GS0 gs /Fm0 Do Q 0 0 0 1 K 1 j 1 J [0 2.997]0 d /GS1 gs q 1 0 0 1 74.3631 368.4103 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 71.3661 368.4103 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q [0 2.997]0 d q 1 0 0 1 74.3631 331.2025 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 71.3661 331.2025 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q BT 0 0 0 1 k /T1_0 1 Tf 10 0 0 10 70.8661 724.8299 Tm (https://doi.org/10.33878/2073-7556-2024-23-1-52-58)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0.023 Tw 19 0 0 19 156.49 695.3259 Tm [(\033\016\222)21(\215\007\216)21(\026)11(\013\026\020 \002\016\222\016\n\227\220\220 \221\002\205\024\025\203 \n\220\ \n\220 )]TJ 0 Tw 1.909 -1.105 Td [(\221\002\220\022)-23.3(\024\016\026)11.1(\013\006)-9.9(\026)11(\013\026\220\017\016\006\n)10(\025\024\022)-23.3(\002\013\n\016)]TJ 0 0 0 1 k /GS1 gs 0.023 Tw 14 0 0 14 70.8661 649.822 Tm [(\037)20(\220\026\022)-23.3(\036.\030., \031)70.1(\016\r\025\002\n\205\001\022)-23.3(\200.\b)-31(., \021\025\007\201\013\026\n\220\001\013\022)-23.3(\213.\004., \037)31(\025\007\016\006\001\220\n)10(\025\r\022)-23.3(\t.\213., \031)70(\215\006\013\002\016\r\013\022)-23.3(\005.\b)-31(., )]TJ 0 -1.143 TD [(\214\025\001\201\013\002\016\001\n)10.1(\025\022)-23.3(\036.\037., \b\001\220\006\220\024\025\r\022)-23.2(\b)-31(.\t., \004\007\013\201\220\024\220\002\025\r\013\022)-23.2(\035.\200.)]TJ 10 0 0 10 70.8661 616.1527 Tm [(\210\031\214)42(\240 \253\213\005\030\226 \025\001\n)10(\025\007\025\202\220\220\273 \005\220\001\222\201\002\013\r\013 \033\025\ \006\006\220\220 \(\215\007.\022)-23.3(1)150(4-\205 \007\220\001\220\205, \201.\022)-23.3(63, \202)62.1(.\022)-23.3(\033\025\006)-10(\026)11(\025\r-\001\013)-84(-)-52(\255\025\001\215)31.1(, 3)58(4403)69(7)127(, \033\025\006\006\220\205\))]TJ /T1_0 1 Tf 9 0 0 9 119.0551 597.6487 Tm (\037\036\035\034 \215\207\207\035\036\200\255\216\201\217\215\243: \025\016\ \205\006\025\024\022 \032\031\016\205\023\022\024\026\024\020 \032\031\016\ \031\013\203\025\025 \033\032\002\003\n\017 \013\025\001\013\025 \033\032\ \025)Tj /Span<>> BDC ( )Tj EMC (IV \t\024\026\030\025\025.)Tj 0.079 Tw 0 -1.111 TD (\201\037\215\036\217\220\235 \215)Tj /Span<>> BDC ( )Tj EMC (\240\036\220\255\200\235: \033\032\n\027\031\030\031\021 \032\031\024\032\ \n\t\033\031\013\024\025\027\021\020\017 \026\021\026\023\025\016 \032\031\ \016\205\023\022\024\026\024\n\027 \023\031\006\031\021\025\002 84 \005\n\ \023\022\021\020\004 \t\025\003\033\024\n\003\021\020\003 )Tj -0.027 Tw T* (\032\026\013\n\003 \033\032\002\003\n\017 \013\025\001\013\025 \t\024\026\ \030\025\025 \tT3-T4\026N0-2M1 \t)Tj /Span<>> BDC ( )Tj EMC (\003\031\024\026\t\024\026\024\025\006\031\t\013\025\003 \033\n\032\026\204\ \031\021\025\031\003 \n\024\030\026\023\031\021\021\020\004 \n\032\202\026\ \021\n\027, \013\n\024\n\032\020\003 )Tj 0.023 Tw T* (\005\020\023\025 \027\020\033\n\023\021\031\021\020 \032\031\016\031\013\ \203\025\025 \033\032\002\003\n\017 \013\025\001\013\025 \t)Tj /Span<>> BDC ( )Tj EMC (2015 \033\n)Tj /Span<>> BDC ( )Tj EMC (2020 \202\202.)Tj 0.296 Tw T* (\212\036\221\214\035\034\220\201\220\235: \021\031\t\n\t\024\n\002\024\031\ \023\022\021\n\t\024\022 \013\n\023\n\032\031\013\024\026\023\022\021\n\202\ \n \026\021\026\t\024\n\003\n\016\026 \032\026\016\027\025\023\026\t\022\ \205)Tj /Span<>> BDC ( )Tj EMC (5)Tj /Span<>> BDC ( )Tj EMC (\(5,9%\) \005\n\023\022\021\020\004, \033\n\t\023\031)Tj 0 Tw (-)Tj 0.132 Tw 0 -1.111 TD (\n\033\031\032\026\203\025\n\021\021\026\002 \023\031\024\026\023\022\021\ \n\t\024\022 \021\026\005\023\007\030\026\023\026\t\022 \027)Tj /Span<>> BDC ( )Tj EMC (1)Tj /Span<>> BDC ( )Tj EMC (\(1,2%\) \t\023\205\006\026\031. \255\033\031\032\026\024\025\027\021\020\ \031 \027\003\031\001\026\024\031\023\022\t\024\027\026 \033\n)Tj /Span<>> BDC ( )Tj EMC (\016\026\013\032\020\024\025\007 )Tj 0.082 Tw 0 -1.111 TD (\025\023\031\n\t\024\n\003\020 \005\020\023\025 \027\020\033\n\023\021\031\ \021\020 66)Tj /Span<>> BDC ( )Tj EMC (\(78,6%\) \005\n\023\022\021\020\003 \027)Tj /Span<>> BDC ( )Tj EMC (\t\032\031\030\021\025\031 \t\032\n\013\025 17,9 \003\031\t\002\203\031\027\ . \032\n\202\032\031\t\t\025\032\n\027\026\021\025\031 \016\026\005\n\023\ \031)Tj 0 Tw (-)Tj 0.057 Tw T* (\027\026\021\025\002 \027\020\002\027\023\031\021\n \205)Tj /Span<>> BDC ( )Tj EMC (60)Tj /Span<>> BDC ( )Tj EMC (\(71,4%\) \005\n\023\022\021\020\004 \025)Tj /Span<>> BDC ( )Tj EMC [(\006\026\211\031 \033\032\n\002\027\023\002\023\n\t\022 )0.5(\003\031\024\026\t\024\026\024\025\006\031\t\013\025\003 \033\n\032\026\204\ \031\021\025\031\003 \033\031\006\031\021\025 \(42,9%\), )]TJ 0.074 Tw T* (\005\032\007\001\025\021\020 \(19%\), \023\031\202\013\025\004 \(15,5%\)\ . \207\024\026\005\025\023\025\016\026\203\025\002 \n\033\205\004\n\023\031\ \027\n\202\n \033\032\n\203\031\t\t\026 \006\026\211\031 \n\024\003\031\006\ \031\021\026 \205)Tj /Span<>> BDC ( )Tj EMC (\005\n\023\022\021\020\004, \033\n\023\205\006\026\027)Tj 0 Tw (-)Tj 0.062 Tw T* [(\001\025\004 )0.5(\033\031\032\025\n\033\031\032\026\203\025\n\021\021\205\007 )0.5(\t\025\t\024\031\003\021\205\007 \004\025\003\025\n\024\031\032\026\033\025\ \007 )0.6(\033\n)]TJ /Span<>> BDC ( )Tj EMC [(\t\032\026\027\021\031\021\025\007 )0.5(\t)]TJ /Span<>> BDC ( )Tj EMC 28.2 0 Td [(\005\n\023\022\021\020\003\025, \013\n\024\n\032\020\003 )0.5(\027)]TJ /Span<>> BDC ( )Tj EMC (\013\n\003\033\023\031\013\t \023\031\006\031\021\025\002 )Tj 0.038 Tw -28.2 -1.111 Td [(\005\020\023 )0.6(\027\013\023\007\006\031\021 )0.6(\013\205\032\t )0.5(\033\032\031\030\n\033\031\032\026\203\025\n\021\021\n\017 )0.7(\023\205\006\031\027\n\017 )0.6(\024\031\032\026\033\025\025 )0.6(\(\032)]TJ /Span<>> BDC ( )Tj EMC 24.281 0 Td (=)Tj /Span<>> BDC ( )Tj EMC 0.77 0 Td [(0,01\). )0.6(\212\031\202\032\031\t\t\025\n\021\021\026\002 )0.5(\003\n\030\031\023\022 )0.5(\033\032\n\033\n\032\203\025\n\021\026\023\022\021\020\004 )]TJ -25.051 -1.111 Td (\032\025\t\013\n\027 \222\n\013\t\026 \033\n\013\026\016\026\023\026, \006\ \024\n \001\026\021\t\020 \021\026\t\024\205\033\023\031\021\025\002 \023\ \031\024\026\023\022\021\n\202\n \025\t\004\n\030\026 \205)Tj /Span<>> BDC ( )Tj EMC (\005\n\023\022\021\020\004 \032\026\013\n\003 \033\032\002\003\n\017 \013\ \025\001\013\025 IV \t\024\026)Tj 0 Tw (-)Tj 0.049 Tw T* (\030\025\025 \027\020\001\031 \027)Tj /Span<>> BDC ( )Tj EMC (4,1 \032\026\016\026 \033\032\025)Tj /Span<>> BDC ( )Tj EMC (\013\026\021\203\031\032\n\003\026\024\n\016\031 \005\032\007\001\025\021\ \020, \027)Tj /Span<>> BDC ( )Tj EMC (2,9 \032\026\016)Tj /Span<>> BDC ( )Tj EMC (\227 \033\032\025)Tj /Span<>> BDC ( )Tj EMC (\021\026\023\025\006\025\025 \003\031\024\026\t\024\026\016\n\027 \027)Tj /Span<>> BDC ( )Tj EMC (\033\031\006\031\021\025, \027)Tj /Span<>> BDC ( )Tj EMC (1,5)Tj /Span<>> BDC ( )Tj EMC (\227 )Tj 0.023 Tw T* (\033\032\025)Tj /Span<>> BDC ( )Tj EMC (\n\030\021\n\027\032\031\003\031\021\021\n\003 \033\n\032\026\204\031\021\ \025\025 \n\024\030\026\023\031\021\021\020\003\025 \003\031\024\026\t\024\ \026\016\026\003\025 \021\031\t\013\n\023\022\013\025\004 \n\032\202\026\ \021\n\027.)Tj 0.003 Tc 0.349 Tw 0 -1.111 TD (\221\201\222\035\223\224\036\217\215\036: \021\025\016\013\026\002 \033\031\ \032\031\030\021\002\002 \032\031\016\031\013\203\025\002 \033\032\002\003\ \n\017 \013\025\001\013\025 \t)Tj /Span<>> BDC ( )Tj EMC [(\f\n\032\003\025\032\n\027\026\021\025\031\003 \033\032\031\027\031\021\024\ \025\027\021\n\017 \025\023\031\n\t\024\n\003\020)3.1( )]TJ 0.001 Tc 0.35 Tw 0 -1.111 TD (\033\032\025)Tj /Span<>> BDC ( )Tj EMC 2.064 0 Td [(\003\031\024\026\t\024\026\024\025\006\031\t\013\n\003 )0.5(\032\026\013\031 )0.5(\t\n\033\032\n\027\n\204\030\026\031\024\t\002 \033\032\025\031\003\023\031\ \003\n\017 )0.5(\006\026\t\024\n\024\n\017 )0.5(\021\031\t\n\t\024\n\002\024\031\023\022\021\n\t\024\025 )0.5(\026\021\026\t\024\n\003\n\016\026)1( )]TJ 0 Tc 0.216 Tw -2.064 -1.111 Td (\(5,9%\) \025)Tj /Span<>> BDC ( )Tj EMC (\033\n\t\023\031\n\033\031\032\026\203\025\n\021\021\n\017 \023\031\024\026\ \023\022\021\n\t\024\025 \(1,2%\). \214)Tj /Span<>> BDC ( )Tj EMC (\005\n\023\022\021\020\004 \t)Tj /Span<>> BDC ( )Tj EMC (\202\031\021\031\032\026\023\025\016\n\027\026\021\021\n\017 \f\n\032\003\ \n\017 \032\026\013\026 \033\032\002\003\n\017 )Tj 0.125 Tw T* (\013\025\001\013\025 \033\032\031\030\033\n\006\024\025\024\031\023\022\021\ \n \021\026\006\025\021\026\024\022 \023\031\006\031\021\025\031 \t)Tj /Span<>> BDC ( )Tj EMC (\t\025\t\024\031\003\021\n\017 \004\025\003\025\n\024\031\032\026\033\025\ \025 \027)Tj /Span<>> BDC ( )Tj EMC (\t\n\006\031\024\026\021\025\025 \t)Tj /Span<>> BDC ( )Tj EMC (\024\026\032\202\031\024\021\020\003\025 \033\032\031)Tj 0 Tw (-)Tj T* (\033\026\032\026\024\026\003\025.)Tj /T1_2 1 Tf 0.01 Tc -0.031 Tw 8 0 0 8 70.9061 402.3795 Tm [(\037\036\035\034\033\032\031\033)5( \030\036\027\032\026:)]TJ /T1_0 1 Tf 0 Tc -0.026 Tw 8.444 0 Td ( \032\031\016\031\013\203\025\002 \033\032\002\003\n\017 \013\025\001\013\ \025, \003\031\024\026\t\024\026\024\025\006\031\t\013\025\017 \032\026\013\ \033\032\002\003\n\017 \013\025\001\013\025, \021\031\t\n\t\024\n\002\024\ \031\023\022\021\n\t\024\022 \026\021\026\t\024\n\003\n\016\026, \n\024\030\ \026\023\031\021\021\020\031 \003\031\024\026)Tj 0 Tw (-)Tj 0.023 Tw -8.449 -1.2 Td (\t\024\026\016\020, \033\032\031\027\031\021\024\025\027\021\026\002 \013\ \025\001\031\006\021\026\002 \t\024\n\003\026.)Tj /T1_2 1 Tf 0.01 Tc 0.018 Tw 0.005 -1.909 Td [(\037\027\025\024\036\023\037\022)5( \023\025\022\033\021\033\030\027\032:)]TJ /T1_0 1 Tf 0 Tc 0.023 Tw 10.401 0 Td ( \026\027\024\n\032\020 \016\026\002\027\023\002\007\024 \n\005 \n\024\t\ \205\024\t\024\027\025\025 \013\n\021\f\023\025\013\024\026 \025\021\024\ \031\032\031\t\n\027)Tj /T1_2 1 Tf 0.033 Tc 0.033 Tw -10.401 -2.617 Td [(\020\036\017)4.7( \016\023\022\023\021\027\032\026\025\023\017:)]TJ /T1_3 1 Tf 0.023 Tc 0.038 Tw 9.205 0 Td ( \025\017\021)Tj /Span<>> BDC ( )Tj EMC (\210.\222., \206\036\r\024\030\022\016\027)Tj /Span<>> BDC ( )Tj EMC (\236.\202., \221\024\035\007\026\021\022\017\027\026)Tj /Span<>> BDC ( )Tj EMC (\203.\200., \025\024\035\036\f\027\017\022\024\r)Tj /Span<>> BDC ( )Tj EMC (\213.\203., \206\031\f\026\030\036\r\026)Tj /Span<>> BDC ( )Tj EMC (\204.\202., \207\024\027\007\026\030\036\027\022\024)Tj /Span<>> BDC ( )Tj EMC (\210.\025., \202\027\017\f\017\n\024\r)Tj /Span<>> BDC ( )Tj EMC [(\202.\213.,)23( )]TJ 0.052 Tw -9.21 -1.2 Td (\200\035\026\007\017\n\017\030\024\r\026)Tj /Span<>> BDC ( )Tj EMC (\214.\236. \217\036\031\035\034\021\026\021\t \030\036\036\022\006\017\ \017 \023\030\016\n\024\005 \022\017\001\022\017 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\n\036\021\026\f\021\026\021\017\004\036\f\022\024\n \030\026\022\036. )Tj /T1_0 1 Tf -0.023 Tw (\222\n\023\n\033\032\n\013\024\n\023\n\202\025\002.)Tj /T1_3 1 Tf 0.052 Tw ( 2024; \021.)Tj /Span<>> BDC ( )Tj EMC (23, \225)Tj /Span<>> BDC ( )Tj EMC (1, \f.)Tj /Span<>> BDC ( )Tj EMC [(52\22658.)23( )]TJ -0.023 Tw 0 -1.2 TD (https://doi.org/10.33878/2073-7556-2024-23-1-52-58)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0 Tc 0.023 Tw 18 0 0 18 134.8244 305.0331 Tm [(Results of r)31(ectal r)31.1(esection in metastatic cancer)]TJ 0 0 0 1 k /GS1 gs 14 0 0 14 70.8661 280.5292 Tm [(Oleg\022)-23.3(I.\022)-23.2(Kit, Y)40(uri\022)-23.2(A)-31(.\022)-23.3(Ge)11(v)10(orky)21(an, Natalia\022)-23.3(V)62(.\022)-23.3(Soldatkina, Ev)10(geny\022)-23.2(N.\022)-23.3(K)41(olesnik)11.1(ov)21(, )]TJ 0 -1.143 TD [(Marina\022)-23.2(A)-31(.\022)-23.3(Gusar)31(e)11(v)10(a, Olga\022)-23.3(K.\022)-23.3(Bondar)31(enk)11.1(o, Ale)21(x)11(ander\022)-23.2(E.\022)-23.3(Anisimov)21(, )]TJ 0 Tw 0 -1.143 TD [(L)20(y)10(ubov\022)-23.3(Y)45(.\022)-23.3(Vladimir)20.1(ov)10(a)]TJ 0.023 Tw 10 0 0 10 70.8661 230.86 Tm [(National Medical Resear)31.1(ch Center of Oncology \(str)52.1(. 1)150(4th line, 63, Rostov)-51.9(-on-Don, 3)58(4403)69(7)127(, Russia\))]TJ /T1_0 1 Tf 9 0 0 9 119.0551 212.356 Tm [(AIM: to ev)16(aluate results of rectal resection in metastatic rectal cancer)51(.)]TJ 0.013 Tw 0 -1.111 TD [(P)45(A)45(TIENT)-9.9(S A)53(ND METHODS: a retrospectiv)13(e analysis of the results of treatment of 84 patients with sym)16(p)13(tomatic rectal )]TJ 0.023 Tw T* [(cancer at stag)12(e IV)72(, who under)-32(w)12(ent rectal resection in 2015-2020.)]TJ 0.042 Tw T* [(RESUL)30(T)-10(S: anastomo)13(tic leak dev)13.1(eloped in 5 \(5.9%\) patients. P)15(ostoperativ)13(e mor)-40(tality rate w)13(as 1 \(1.2%\). Ileostom)11(y )]TJ 0.226 Tw T* [(closure w)13(as per)-33.9(for)-14(med in 66 patients \(78.6%\) 17.9 months af)-46(ter initial surg)12(er)-43(y)32(. Prog)14(ression of the disease )]TJ 0.203 Tw 0 -1.111 TD [(w)13(as detected in 60 \(71.4%\) patients at following org)12.1(ans: liv)13(er \(42.9%\), per)-37(itoneum \(19%\), lungs \(15.5%\). )]TJ 0.131 Tw 0 -1.111 TD [(S)28(tabilization )0.5(w)13(as signif)-42.9(icantly higher af)-45.9(ter systemic chemo)13(therap)12(y before and af)-46(ter per)-37(ioperativ)13(e chemo)13(therap)12(y )]TJ 0.017 Tw T* [(com)16(par)-36.9(ing to patients who had p)46(reoperativ)13.1(e radiation )0.5(\(p)]TJ /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC [(0.013\). Propor)-40(tional Co)14(x reg)14(ression model r)-37(isk)-23(s show)12(ed )]TJ 0.025 Tw T* [(that the chances of death in patients with )0.5(adv)16(anced rectal cancer )0.5(af)-46(ter surg)12(er)-43(y w)13(as 4.1 times higher for per)-36.9(itoneal )]TJ 0.023 Tw T* [(carcinomatosis, 2.9 times for liv)13(er metastases and 1.5 for multi org)12(an metastasis.)]TJ 0.089 Tw T* [(C)21(ON)22(CLUSION: low anter)-36.9(ior resection with defunctioning ileostom)11.1(y is associated with accep)13(table anastomo)13(tic leak )]TJ 0.062 Tw T* [(rate \(5.9%\) and mor)-40(tality \(1.2%\). Systemic chemo)13(therap)12(y in combination with targ)12(et ag)12(ents is p)46(referable initial )]TJ 0.023 Tw T* [(treatment in patients with metastatic rectal cancer)51(.)]TJ ET 1 0.68 0 0.12 k /GS0 gs q 1 0 0 1 70.8661 606.1528 cm 0 0 m 0 0 l 0 -11.339 l 42.52 -11.339 l 42.52 0 l h f Q BT 0 0 0 0 k /T1_2 1 Tf 0 Tw 9 0 0 9 76.0071 597.2255 Tm (\021\033\r\035\f\033)Tj ET 1 0.68 0 0.12 k q 1 0 0 1 70.8661 220.8604 cm 0 0 m 0 0 l 0 -11.339 l 42.52 -11.339 l 42.52 0 l h f Q BT 0 0 0 0 k /T1_2 1 Tf 9 0 0 9 73.5728 211.9331 Tm (ABSTRACT)Tj 1 0.68 0 0.12 k /T1_1 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\033\030\031\030\213\b)-20.9(\035\231\213\233\t \021\032)50(\b)42(\032\231\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj -51.938 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 23, \023\0221)69(, 202)69(4)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 23, \023\0221)69(, 202)69(4)]TJ /T1_4 1 Tf 25 0 0 25 28.0527 56.0378 Tm (52)Tj ET q 0 g 0 G 0 j 0 J /Fm1 Do Q 0 0 0 0 k 396.85 725.67 59.155 11.338 re f /PlacedPDF /MC0 BDC q 397.481 736.808 m 397.242 736.808 397.049 736.616 397.049 736.376 c 397.049 736.376 l 397.049 726.285 l 397.049 726.045 397.242 725.853 397.481 725.853 c 397.481 725.853 l 455.382 725.853 l 455.62 725.853 455.815 726.045 455.815 726.285 c 455.815 726.285 l 455.815 736.376 l 455.815 736.616 455.62 736.808 455.382 736.808 c 455.382 736.808 l h W n q 0 g -0.0000005 -10.9560913 -10.9560913 0.0000005 426.4320445 736.8086309 cm BX /Sh0 sh EX Q Q q 396.85 725.67 59.155 11.337 re W n 0 0 0 0.84 k q 1 0 0 1 413.5634 732.4249 cm 0 0 m -0.025 0.1 -0.063 0.196 -0.112 0.287 c -0.157 0.374 -0.218 0.451 -0.292 0.515 c -0.37 0.582 -0.46 0.632 -0.558 0.664 c -0.669 0.701 -0.786 0.719 -0.903 0.717 c -1.076 0.722 -1.247 0.681 -1.4 0.6 c -1.536 0.526 -1.652 0.42 -1.74 0.292 c -1.83 0.158 -1.895 0.008 -1.934 -0.149 c -2.018 -0.48 -2.018 -0.827 -1.934 -1.158 c -1.896 -1.316 -1.83 -1.466 -1.74 -1.602 c -1.653 -1.731 -1.536 -1.837 -1.4 -1.912 c -1.247 -1.993 -1.076 -2.033 -0.903 -2.029 c -0.774 -2.032 -0.647 -2.006 -0.528 -1.955 c -0.427 -1.906 -0.337 -1.837 -0.263 -1.753 c -0.185 -1.665 -0.124 -1.563 -0.082 -1.453 c -0.034 -1.338 0 -1.218 0.019 -1.094 c 0.635 -1.094 l 0.624 -1.297 0.578 -1.497 0.497 -1.684 c 0.421 -1.857 0.312 -2.015 0.175 -2.146 c 0.039 -2.277 -0.123 -2.379 -0.3 -2.446 c -0.492 -2.519 -0.695 -2.555 -0.9 -2.552 c -1.15 -2.557 -1.397 -2.506 -1.625 -2.404 c -1.829 -2.307 -2.01 -2.169 -2.157 -1.997 c -2.308 -1.821 -2.423 -1.617 -2.497 -1.397 c -2.655 -0.924 -2.655 -0.412 -2.497 0.061 c -2.423 0.281 -2.307 0.485 -2.157 0.661 c -2.01 0.833 -1.829 0.973 -1.625 1.07 c -1.398 1.174 -1.15 1.226 -0.9 1.222 c -0.707 1.223 -0.515 1.196 -0.329 1.14 c -0.159 1.088 0.001 1.006 0.144 0.898 c 0.278 0.793 0.39 0.662 0.473 0.513 c 0.562 0.349 0.615 0.167 0.629 -0.019 c 0 -0.019 l 0 0 l f Q q 1 0 0 1 414.6923 733.5723 cm 0 0 m 0.584 0 l 0.584 -1.328 l 0.662 -1.204 0.771 -1.103 0.9 -1.033 c 1.046 -0.951 1.213 -0.91 1.381 -0.914 c 1.627 -0.9 1.869 -0.979 2.058 -1.137 c 2.234 -1.312 2.325 -1.556 2.305 -1.803 c 2.305 -3.596 l 1.716 -3.596 l 1.716 -1.976 l 1.724 -1.817 1.678 -1.66 1.585 -1.53 c 1.486 -1.43 1.347 -1.379 1.206 -1.392 c 1.114 -1.39 1.024 -1.408 0.94 -1.445 c 0.865 -1.479 0.798 -1.529 0.744 -1.591 c 0.687 -1.656 0.645 -1.73 0.616 -1.812 c 0.586 -1.896 0.571 -1.986 0.571 -2.077 c 0.571 -3.615 l 0 -3.615 l 0 0 l f Q q 1 0 0 1 418.0385 731.1235 cm 0 0 m 0 -0.099 0.014 -0.198 0.043 -0.292 c 0.069 -0.382 0.112 -0.466 0.17 -0.54 c 0.229 -0.611 0.304 -0.669 0.388 -0.709 c 0.486 -0.754 0.594 -0.776 0.702 -0.773 c 0.845 -0.78 0.987 -0.742 1.108 -0.664 c 1.217 -0.582 1.296 -0.468 1.336 -0.337 c 1.881 -0.337 l 1.827 -0.603 1.675 -0.838 1.456 -0.996 c 1.35 -1.073 1.231 -1.131 1.105 -1.169 c 0.971 -1.208 0.831 -1.229 0.691 -1.227 c 0.509 -1.227 0.328 -1.191 0.16 -1.121 c 0.007 -1.063 -0.13 -0.972 -0.244 -0.855 c -0.356 -0.73 -0.44 -0.583 -0.491 -0.422 c -0.548 -0.243 -0.576 -0.056 -0.574 0.133 c -0.575 0.313 -0.545 0.493 -0.486 0.664 c -0.426 0.826 -0.335 0.974 -0.22 1.102 c 0.004 1.375 0.338 1.534 0.691 1.535 c 0.883 1.539 1.072 1.495 1.243 1.408 c 1.402 1.326 1.541 1.209 1.649 1.067 c 1.759 0.922 1.838 0.757 1.883 0.582 c 1.932 0.396 1.945 0.203 1.92 0.013 c 0 0.013 l 0 0 l 1.342 0.377 m 1.335 0.468 1.315 0.557 1.283 0.643 c 1.253 0.724 1.209 0.798 1.153 0.863 c 1.097 0.922 1.03 0.97 0.957 1.004 c 0.874 1.043 0.783 1.063 0.691 1.062 c 0.6 1.062 0.509 1.044 0.425 1.009 c 0.345 0.976 0.273 0.926 0.213 0.863 c 0.153 0.799 0.105 0.724 0.072 0.643 c 0.037 0.559 0.017 0.468 0.014 0.377 c 1.355 0.377 l h f Q q 1 0 0 1 422.1581 731.7051 cm 0 0 m -0.012 0.144 -0.082 0.276 -0.194 0.366 c -0.31 0.452 -0.451 0.495 -0.595 0.489 c -0.675 0.488 -0.755 0.476 -0.831 0.452 c -0.918 0.424 -0.998 0.375 -1.062 0.311 c -1.142 0.229 -1.202 0.131 -1.24 0.024 c -1.29 -0.132 -1.312 -0.296 -1.304 -0.459 c -1.304 -0.569 -1.292 -0.677 -1.267 -0.784 c -1.244 -0.885 -1.202 -0.983 -1.145 -1.07 c -1.09 -1.154 -1.016 -1.224 -0.93 -1.275 c -0.833 -1.33 -0.722 -1.356 -0.611 -1.352 c -0.457 -1.357 -0.307 -1.301 -0.194 -1.195 c -0.078 -1.077 -0.005 -0.922 0.011 -0.757 c 0.587 -0.757 l 0.556 -1.055 0.419 -1.332 0.202 -1.538 c -0.022 -1.721 -0.306 -1.815 -0.595 -1.803 c -0.777 -1.806 -0.958 -1.771 -1.126 -1.7 c -1.293 -1.642 -1.445 -1.547 -1.57 -1.421 c -1.68 -1.297 -1.763 -1.151 -1.814 -0.993 c -1.87 -0.822 -1.898 -0.643 -1.896 -0.462 c -1.898 -0.276 -1.871 -0.091 -1.817 0.087 c -1.766 0.252 -1.682 0.405 -1.57 0.537 c -1.459 0.664 -1.323 0.766 -1.168 0.834 c -0.991 0.914 -0.798 0.955 -0.603 0.954 c -0.457 0.954 -0.311 0.935 -0.17 0.895 c -0.039 0.858 0.084 0.799 0.194 0.72 c 0.302 0.643 0.393 0.543 0.459 0.428 c 0.531 0.298 0.572 0.155 0.582 0.008 c 0 0.008 l 0 0 l f Q q 1 0 0 1 423.2177 733.5723 cm 0 0 m 0.577 0 l 0.577 -2.048 l 1.615 -0.985 l 2.322 -0.985 l 1.323 -1.944 l 2.417 -3.604 l 1.716 -3.604 l 0.919 -2.337 l 0.577 -2.669 l 0.577 -3.604 l 0 -3.604 l h f Q q 1 0 0 1 427.0585 732.5762 cm 0 0 m 0.436 0 l 0.436 0.218 l 0.429 0.352 0.448 0.486 0.488 0.614 c 0.521 0.705 0.577 0.786 0.651 0.85 c 0.717 0.905 0.795 0.943 0.879 0.961 c 0.966 0.979 1.056 0.988 1.145 0.988 c 1.28 0.993 1.416 0.981 1.548 0.954 c 1.548 0.505 l 1.509 0.516 1.469 0.523 1.429 0.528 c 1.379 0.532 1.33 0.532 1.28 0.528 c 1.209 0.53 1.14 0.511 1.081 0.473 c 1.019 0.419 0.987 0.337 0.999 0.255 c 0.999 -0.011 l 1.498 -0.011 l 1.498 -0.441 l 1.009 -0.441 l 1.009 -2.622 l 0.436 -2.622 l 0.436 -0.428 l 0.005 -0.428 l 0.005 0 l 0 0 l f Q q 1 0 0 1 430.1 729.8965 cm 0 0 m -0.191 -0.003 -0.381 0.032 -0.559 0.104 c -0.715 0.167 -0.856 0.264 -0.972 0.388 c -1.091 0.512 -1.181 0.659 -1.238 0.82 c -1.356 1.18 -1.356 1.567 -1.238 1.925 c -1.181 2.087 -1.091 2.234 -0.972 2.358 c -0.856 2.481 -0.715 2.578 -0.559 2.643 c -0.199 2.78 0.198 2.78 0.558 2.643 c 0.714 2.578 0.855 2.481 0.972 2.358 c 1.09 2.234 1.181 2.087 1.237 1.925 c 1.355 1.567 1.355 1.18 1.237 0.82 c 1.181 0.659 1.09 0.512 0.972 0.388 c 0.855 0.266 0.713 0.169 0.558 0.106 c 0.38 0.034 0.191 -0.002 0 0 c 0 0.454 m 0.115 0.451 0.23 0.479 0.332 0.534 c 0.424 0.586 0.502 0.659 0.562 0.746 c 0.624 0.836 0.669 0.936 0.695 1.041 c 0.752 1.26 0.752 1.491 0.695 1.71 c 0.669 1.816 0.625 1.916 0.562 2.005 c 0.502 2.091 0.423 2.163 0.332 2.215 c 0.123 2.323 -0.126 2.323 -0.335 2.215 c -0.427 2.163 -0.505 2.091 -0.566 2.005 c -0.628 1.916 -0.673 1.816 -0.699 1.71 c -0.756 1.491 -0.756 1.26 -0.699 1.041 c -0.672 0.936 -0.627 0.836 -0.566 0.746 c -0.506 0.659 -0.427 0.586 -0.335 0.534 c -0.232 0.478 -0.117 0.451 0 0.454 c f Q q 1 0 0 1 431.8979 732.5762 cm 0 0 m 0.531 0 l 0.531 -0.505 l 0.55 -0.43 0.583 -0.359 0.629 -0.297 c 0.681 -0.229 0.74 -0.167 0.807 -0.114 c 0.877 -0.059 0.956 -0.014 1.039 0.019 c 1.123 0.053 1.213 0.07 1.304 0.069 c 1.52 0.069 l 1.52 -0.486 l 1.395 -0.467 l 1.269 -0.467 l 1.178 -0.468 1.087 -0.488 1.004 -0.526 c 0.917 -0.565 0.839 -0.625 0.778 -0.699 c 0.716 -0.783 0.669 -0.878 0.643 -0.98 c 0.604 -1.104 0.584 -1.233 0.586 -1.362 c 0.586 -2.603 l 0.01 -2.603 l 0.01 0 l 0 0 l f Q q 1 0 0 1 437.3666 729.9683 cm 0 0 m -0.577 0 l -0.577 0.364 l -0.649 0.23 -0.759 0.121 -0.893 0.047 c -1.022 -0.029 -1.169 -0.07 -1.32 -0.072 c -1.595 -0.095 -1.866 0.002 -2.064 0.194 c -2.234 0.413 -2.316 0.687 -2.295 0.964 c -2.295 2.608 l -1.719 2.608 l -1.719 1.014 l -1.735 0.843 -1.689 0.67 -1.588 0.531 c -1.492 0.433 -1.357 0.382 -1.219 0.39 c -1.116 0.387 -1.012 0.406 -0.917 0.446 c -0.84 0.479 -0.772 0.531 -0.72 0.595 c -0.667 0.661 -0.63 0.738 -0.611 0.82 c -0.588 0.911 -0.577 1.003 -0.577 1.097 c -0.577 2.611 l 0 2.611 l 0 0 l f Q q 1 0 0 1 437.9877 732.5762 cm 0 0 m 0.545 0 l 0.545 -0.353 l 0.617 -0.209 0.736 -0.094 0.882 -0.026 c 1.03 0.04 1.19 0.073 1.352 0.072 c 1.535 0.075 1.717 0.038 1.883 -0.037 c 2.031 -0.106 2.161 -0.208 2.263 -0.334 c 2.366 -0.465 2.442 -0.615 2.489 -0.775 c 2.54 -0.948 2.566 -1.127 2.566 -1.307 c 2.566 -1.479 2.542 -1.651 2.497 -1.817 c 2.455 -1.973 2.385 -2.121 2.29 -2.252 c 2.099 -2.522 1.789 -2.682 1.458 -2.68 c 1.369 -2.681 1.28 -2.674 1.193 -2.659 c 1.11 -2.644 1.028 -2.618 0.951 -2.584 c 0.875 -2.552 0.802 -2.509 0.736 -2.457 c 0.671 -2.406 0.615 -2.343 0.571 -2.273 c 0.571 -3.575 l -0.005 -3.575 l -0.005 0 l 0 0 l 2.008 -1.307 m 2.008 -1.191 1.993 -1.076 1.963 -0.964 c 1.936 -0.859 1.89 -0.759 1.828 -0.669 c 1.768 -0.584 1.69 -0.514 1.599 -0.462 c 1.503 -0.409 1.395 -0.382 1.286 -0.385 c 1.072 -0.372 0.867 -0.467 0.738 -0.638 c 0.607 -0.836 0.543 -1.072 0.555 -1.31 c 0.554 -1.433 0.57 -1.557 0.603 -1.676 c 0.631 -1.781 0.68 -1.879 0.747 -1.965 c 0.809 -2.044 0.886 -2.109 0.975 -2.157 c 1.071 -2.206 1.178 -2.23 1.286 -2.229 c 1.401 -2.232 1.517 -2.205 1.618 -2.148 c 1.708 -2.096 1.785 -2.025 1.843 -1.939 c 1.903 -1.85 1.945 -1.751 1.968 -1.646 c 1.995 -1.535 2.008 -1.421 2.008 -1.307 c f Q q 1 0 0 1 443.5127 729.9683 cm 0 0 m -0.545 0 l -0.545 0.353 l -0.616 0.211 -0.734 0.099 -0.879 0.034 c -1.027 -0.031 -1.187 -0.065 -1.349 -0.064 c -1.532 -0.067 -1.714 -0.03 -1.88 0.045 c -2.028 0.113 -2.158 0.214 -2.26 0.34 c -2.364 0.47 -2.441 0.62 -2.486 0.781 c -2.538 0.958 -2.564 1.143 -2.563 1.328 c -2.568 1.536 -2.536 1.742 -2.468 1.938 c -2.41 2.097 -2.319 2.242 -2.202 2.364 c -2.101 2.471 -1.977 2.555 -1.838 2.608 c -1.705 2.659 -1.563 2.685 -1.421 2.685 c -1.338 2.685 -1.256 2.678 -1.174 2.664 c -1.091 2.648 -1.01 2.624 -0.932 2.589 c -0.855 2.556 -0.783 2.514 -0.717 2.462 c -0.652 2.411 -0.597 2.349 -0.553 2.279 c -0.553 3.606 l 0.024 3.606 l 0.024 0 l 0 0 l -2.008 1.277 m -2.009 1.166 -1.994 1.056 -1.965 0.948 c -1.939 0.845 -1.896 0.748 -1.835 0.661 c -1.777 0.578 -1.699 0.508 -1.61 0.459 c -1.404 0.355 -1.162 0.355 -0.956 0.459 c -0.866 0.512 -0.789 0.585 -0.73 0.671 c -0.671 0.762 -0.626 0.862 -0.6 0.966 c -0.572 1.076 -0.558 1.188 -0.558 1.301 c -0.543 1.542 -0.612 1.781 -0.751 1.979 c -0.88 2.14 -1.078 2.229 -1.283 2.22 c -1.402 2.224 -1.52 2.196 -1.623 2.138 c -1.714 2.083 -1.793 2.009 -1.852 1.92 c -1.911 1.828 -1.954 1.725 -1.977 1.617 c -1.999 1.505 -2.01 1.392 -2.008 1.277 c f Q q 1 0 0 1 446.3252 730.5499 cm 0 0 m -0.004 -0.052 0.005 -0.104 0.026 -0.151 c 0.052 -0.185 0.094 -0.202 0.136 -0.197 c 0.197 -0.197 l 0.223 -0.2 0.25 -0.2 0.276 -0.197 c 0.276 -0.595 l 0.199 -0.619 l 0.101 -0.64 l 0 -0.656 l -0.085 -0.656 l -0.187 -0.66 -0.288 -0.635 -0.377 -0.584 c -0.461 -0.528 -0.516 -0.437 -0.528 -0.337 c -0.648 -0.451 -0.792 -0.534 -0.951 -0.579 c -1.106 -0.628 -1.269 -0.654 -1.432 -0.656 c -1.546 -0.657 -1.659 -0.641 -1.769 -0.608 c -1.872 -0.579 -1.967 -0.531 -2.053 -0.468 c -2.136 -0.405 -2.203 -0.324 -2.25 -0.231 c -2.3 -0.127 -2.326 -0.012 -2.324 0.104 c -2.33 0.24 -2.299 0.375 -2.236 0.497 c -2.181 0.594 -2.101 0.675 -2.005 0.733 c -1.905 0.791 -1.795 0.833 -1.681 0.855 c -1.562 0.88 -1.442 0.899 -1.32 0.914 c -1.222 0.933 -1.123 0.947 -1.022 0.956 c -0.938 0.963 -0.855 0.977 -0.773 0.999 c -0.708 1.014 -0.649 1.046 -0.6 1.092 c -0.556 1.144 -0.533 1.211 -0.536 1.28 c -0.534 1.344 -0.553 1.408 -0.59 1.46 c -0.624 1.507 -0.668 1.544 -0.72 1.569 c -0.775 1.596 -0.834 1.613 -0.895 1.62 c -0.955 1.624 -1.016 1.624 -1.076 1.62 c -1.215 1.625 -1.354 1.591 -1.474 1.519 c -1.581 1.45 -1.647 1.333 -1.652 1.206 c -2.231 1.206 l -2.227 1.354 -2.185 1.498 -2.108 1.625 c -2.041 1.733 -1.951 1.824 -1.843 1.891 c -1.729 1.96 -1.603 2.007 -1.472 2.032 c -1.329 2.072 -1.183 2.098 -1.036 2.109 c -0.908 2.109 -0.781 2.096 -0.656 2.069 c -0.538 2.044 -0.425 2 -0.321 1.939 c -0.225 1.88 -0.143 1.8 -0.083 1.705 c -0.02 1.599 0.012 1.478 0.008 1.354 c 0.008 0.013 l 0 0 l -0.576 0.728 m -0.674 0.667 -0.785 0.631 -0.9 0.624 c -1.028 0.612 -1.155 0.594 -1.283 0.571 c -1.343 0.561 -1.402 0.547 -1.46 0.528 c -1.515 0.511 -1.566 0.485 -1.612 0.451 c -1.657 0.419 -1.692 0.376 -1.716 0.327 c -1.742 0.267 -1.755 0.203 -1.753 0.138 c -1.755 0.079 -1.735 0.021 -1.697 -0.024 c -1.661 -0.067 -1.615 -0.103 -1.564 -0.127 c -1.509 -0.154 -1.451 -0.171 -1.392 -0.181 c -1.335 -0.19 -1.278 -0.196 -1.222 -0.197 c -1.152 -0.196 -1.083 -0.188 -1.015 -0.173 c -0.94 -0.156 -0.87 -0.127 -0.805 -0.088 c -0.74 -0.048 -0.684 0.004 -0.64 0.066 c -0.594 0.134 -0.571 0.215 -0.574 0.297 c -0.574 0.725 l h f Q q 1 0 0 1 446.6836 732.5762 cm 0 0 m 0.434 0 l 0.434 0.784 l 0.996 0.784 l 0.996 0 l 1.527 0 l 1.527 -0.43 l 0.996 -0.43 l 0.996 -1.822 l 0.993 -1.874 0.993 -1.927 0.996 -1.979 c 1 -2.018 1.011 -2.056 1.031 -2.09 c 1.05 -2.122 1.079 -2.146 1.113 -2.159 c 1.162 -2.177 1.213 -2.185 1.265 -2.183 c 1.387 -2.183 l 1.428 -2.181 1.469 -2.175 1.509 -2.165 c 1.509 -2.608 l 1.323 -2.629 l 1.261 -2.633 1.199 -2.633 1.137 -2.629 c 1.013 -2.633 0.89 -2.619 0.771 -2.587 c 0.688 -2.564 0.613 -2.52 0.553 -2.459 c 0.499 -2.4 0.462 -2.328 0.446 -2.25 c 0.427 -2.155 0.416 -2.059 0.415 -1.963 c 0.415 -0.428 l -0.019 -0.428 l -0.019 0 l 0 0 l f Q q 1 0 0 1 449.0742 731.1235 cm 0 0 m 0 -0.099 0.014 -0.198 0.042 -0.292 c 0.068 -0.382 0.112 -0.466 0.17 -0.54 c 0.229 -0.611 0.303 -0.669 0.388 -0.709 c 0.486 -0.754 0.593 -0.776 0.701 -0.773 c 0.845 -0.78 0.987 -0.742 1.107 -0.664 c 1.216 -0.582 1.296 -0.468 1.336 -0.337 c 1.88 -0.337 l 1.827 -0.603 1.674 -0.838 1.456 -0.996 c 1.349 -1.073 1.231 -1.131 1.105 -1.169 c 0.973 -1.208 0.836 -1.228 0.699 -1.227 c 0.512 -1.23 0.327 -1.196 0.154 -1.126 c 0.003 -1.066 -0.133 -0.973 -0.244 -0.855 c -0.356 -0.73 -0.44 -0.583 -0.491 -0.422 c -0.548 -0.243 -0.576 -0.056 -0.574 0.133 c -0.575 0.313 -0.546 0.493 -0.486 0.664 c -0.426 0.826 -0.336 0.974 -0.221 1.102 c 0.002 1.374 0.334 1.532 0.685 1.535 c 0.877 1.539 1.067 1.495 1.238 1.408 c 1.396 1.326 1.535 1.209 1.644 1.067 c 1.753 0.922 1.833 0.757 1.878 0.582 c 1.927 0.396 1.939 0.203 1.915 0.013 c -0.002 0.013 l 0 0 l 1.341 0.377 m 1.335 0.468 1.315 0.557 1.283 0.643 c 1.253 0.724 1.209 0.798 1.153 0.863 c 1.096 0.926 1.027 0.978 0.951 1.014 c 0.868 1.054 0.777 1.074 0.685 1.073 c 0.594 1.073 0.504 1.055 0.419 1.02 c 0.339 0.986 0.267 0.937 0.207 0.874 c 0.147 0.81 0.099 0.735 0.066 0.653 c 0.031 0.569 0.011 0.479 0.008 0.388 c 1.349 0.388 l h f Q q 1 0 0 1 451.8657 730.7994 cm 0 0 m 0.002 -0.142 0.073 -0.274 0.191 -0.353 c 0.312 -0.423 0.45 -0.458 0.59 -0.454 c 0.651 -0.458 0.711 -0.458 0.773 -0.454 c 0.839 -0.447 0.904 -0.43 0.967 -0.406 c 1.024 -0.385 1.075 -0.349 1.116 -0.303 c 1.155 -0.252 1.174 -0.189 1.168 -0.125 c 1.166 -0.057 1.138 0.008 1.089 0.056 c 1.033 0.107 0.967 0.146 0.895 0.17 c 0.809 0.201 0.72 0.226 0.629 0.245 c 0.329 0.33 l 0.224 0.352 0.121 0.38 0.019 0.415 c -0.076 0.446 -0.166 0.491 -0.247 0.55 c -0.327 0.608 -0.391 0.683 -0.436 0.771 c -0.486 0.873 -0.511 0.986 -0.507 1.1 c -0.512 1.226 -0.475 1.351 -0.404 1.456 c -0.333 1.551 -0.243 1.63 -0.138 1.687 c -0.028 1.747 0.092 1.788 0.215 1.809 c 0.337 1.832 0.462 1.843 0.587 1.843 c 0.716 1.844 0.845 1.83 0.972 1.801 c 1.09 1.774 1.202 1.727 1.304 1.663 c 1.404 1.598 1.488 1.513 1.551 1.413 c 1.621 1.3 1.663 1.173 1.676 1.041 c 1.076 1.041 l 1.059 1.155 0.989 1.253 0.887 1.307 c 0.78 1.355 0.665 1.38 0.547 1.378 c 0.5 1.381 0.452 1.381 0.403 1.378 c 0.35 1.373 0.298 1.36 0.247 1.341 c 0.2 1.325 0.157 1.297 0.122 1.262 c 0.087 1.224 0.069 1.174 0.071 1.124 c 0.069 1.058 0.096 0.995 0.146 0.951 c 0.202 0.903 0.267 0.866 0.337 0.842 c 0.424 0.811 0.512 0.786 0.603 0.768 c 0.917 0.701 l 1.021 0.678 1.124 0.65 1.224 0.616 c 1.319 0.584 1.409 0.539 1.49 0.481 c 1.662 0.359 1.762 0.16 1.755 -0.05 c 1.76 -0.189 1.723 -0.326 1.649 -0.443 c 1.582 -0.551 1.491 -0.642 1.384 -0.709 c 1.267 -0.778 1.14 -0.827 1.007 -0.855 c 0.873 -0.885 0.735 -0.9 0.598 -0.9 c 0.443 -0.902 0.29 -0.883 0.141 -0.845 c 0.01 -0.812 -0.114 -0.753 -0.223 -0.674 c -0.324 -0.601 -0.407 -0.504 -0.465 -0.393 c -0.527 -0.269 -0.559 -0.131 -0.558 0.008 c 0.019 0.008 l 0 0 l f Q 0.146 0.941 0.992 0.044 k q 1 0 0 1 401.2527 729.3892 cm 0 0 m 3.612 2.406 l 3.612 5.296 l 0 5.296 l h f Q 0 0.889 0.676 0 k q 1 0 0 1 404.865 729.3892 cm 0 0 m -3.612 2.406 l -3.612 5.296 l 0 5.296 l h f Q 0.694 0.076 0.209 0 k q 1 0 0 1 403.0589 735.3145 cm 0 0 m -2.2 0 -3.984 -1.784 -3.984 -3.984 c -3.984 -6.184 -2.2 -7.968 0 -7.968 c 2.2 -7.968 3.984 -6.184 3.984 -3.984 c 3.984 -1.784 2.2 0 0 0 c 0 -6.993 m -1.662 -6.993 -3.009 -5.646 -3.009 -3.984 c -3.009 -2.322 -1.662 -0.975 0 -0.975 c 1.662 -0.975 3.009 -2.322 3.009 -3.984 c 3.009 -5.646 1.662 -6.993 0 -6.993 c f Q 0 0.235 0.86 0 k q 1 0 0 1 405.2601 729.2803 cm 0 0 m -1.118 -1.208 -3.015 -1.281 -4.237 -0.159 c -5.159 0.688 -5.459 2.005 -4.999 3.156 c -5.833 3.687 l -6.736 1.681 -5.843 -0.679 -3.836 -1.582 c -2.218 -2.311 -0.312 -1.881 0.836 -0.528 c 0 0 l f Q 0 0 0 0.6 k q 1 0 0 1 397.4813 736.8087 cm 0 0 m -0.238 0 -0.432 -0.193 -0.432 -0.432 c -0.432 -10.524 l -0.432 -10.763 -0.238 -10.956 0 -10.956 c 57.901 -10.956 l 58.139 -10.956 58.333 -10.763 58.333 -10.524 c 58.333 -0.432 l 58.333 -0.193 58.139 0 57.901 0 c h 57.901 -11.155 m 0 -11.155 l -0.348 -11.155 -0.631 -10.872 -0.631 -10.524 c -0.631 -0.432 l -0.631 -0.084 -0.348 0.199 0 0.199 c 57.901 0.199 l 58.249 0.199 58.532 -0.084 58.532 -0.432 c 58.532 -10.524 l 58.532 -10.872 58.249 -11.155 57.901 -11.155 c f Q EMC Q endstream endobj 1999 0 obj <> endobj 2056 0 obj <>stream Adobe Illustrator CS6 (Windows) 2021-04-12T11:45:36+05:00 2021-06-02T10:28:09+05:00 2021-06-02T10:28:09+05:00 1 False False 20.868494 3.999928 Millimeters Cyan Magenta Yellow Black Default Swatch Group 0 C=0 M=24 Y=86 K=0 PROCESS 100.000000 CMYK 0.000000 23.504999 86.022697 0.000000 C=69 M=8 Y=21 K=0 PROCESS 100.000000 CMYK 69.369003 7.635600 20.892700 0.000000 C=0 M=89 Y=68 K=0 PROCESS 100.000000 CMYK 0.000000 88.946404 67.623398 0.000000 C=15 M=94 Y=99 K=4 PROCESS 100.000000 CMYK 14.578501 94.070297 99.160698 4.416000 C=0 M=0 Y=0 K=84 PROCESS 100.000000 CMYK 0.000000 0.000000 0.000000 84.000000 C=0 M=0 Y=0 K=35 PROCESS 100.000000 CMYK 0.000000 0.000000 0.000000 35.000000 C=0 M=0 Y=0 K=60 PROCESS 100.000000 CMYK 0.000000 0.000000 0.000000 60.000004 Document application/pdf proof:pdf xmp.did:804244B35A9BEB118A6FC3C256996E2F uuid:08e30110-bdb7-4606-97ca-63fb62cbcecc uuid:21079f76-f6d7-4329-b725-f2fb35af5114 uuid:722f8893-0b3c-4402-87fb-c713f1fa0e26 uuid:21079f76-f6d7-4329-b725-f2fb35af5114 uuid:21079f76-f6d7-4329-b725-f2fb35af5114 proof:pdf saved xmp.iid:804244B35A9BEB118A6FC3C256996E2F 2021-04-12T11:45:42+05:00 Adobe Illustrator CS6 (Windows) / endstream endobj 2055 0 obj <>/Border[0 0 0]/H/N/Rect[394.85 739.008 458.005 723.67]/Subtype/Link/Type/Annot>> endobj 2057 0 obj <> endobj 1995 0 obj [2058 0 R 2059 0 R 2060 0 R 2061 0 R 2062 0 R 2063 0 R 2064 0 R 2065 0 R 2066 0 R 2067 0 R 2068 0 R 2069 0 R 2070 0 R 2071 0 R 2072 0 R 2073 0 R 2074 0 R 2075 0 R 2076 0 R 2077 0 R] endobj 1996 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\037)31(\025\001\026\002\025\007\220\002\215\016\024\013\205 \227\220\002\n\215\007\ \205\002\001\013\205 \201\220\007\013\026)11(\013\227\220\205 \220\022\f\025\n)10(\025\r\013\205 )]TJ 0 -1 TD [(\221\025\201\n)10(\025\217\001\013\205 \006\225\220\001\n)-10(\026)11(\016\002\025\026)11(\025\024\220\205 \221\002\220\022\007\016\017\016\001\220\220 \207\002\025\ \001\220\017\016\006\n\220\207 )]TJ T* [(\013\001\013\007\216\001\020\207 \026\002\016\224\220\001 \r\022\006\025\ \017\016\026)11(\013\001\220\220 \006\022\202)10(\016\024\025\002\002\025\016\024 3\2344\022\006)-10(\026)11(\013\201\220\220)]TJ 32.735 2 Td [(\021ontr)20(olled cir)31(cular dilatation and later)21.1(al subcutaneous sphincter)20(otom)21(y )]TJ 4.673 -1 Td [(for chr)20.1(onic anal f)-20.9(issur)31(es associated with h)11(emorrh)11(oids III-IV)]TJ /T1_1 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 42.5896 724.8299 Tm (REFERENCES)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf 0 Tc 0.24 Tw 8 0 0 8 42.5197 711.9952 Tm (1.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(A)-25(gapov)]TJ /Span<>> BDC ( )Tj EMC [(M.A., Al)-31(iev)]TJ /Span<>> BDC ( )Tj EMC [(F.S)-16(h., A)-24.9(chk)-17(asov)]TJ /Span<>> BDC ( )Tj EMC [(S.I., e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Cl)-30.9(inical guide)]TJ 0 Tw (-)Tj 0.191 Tw -1.296 -1.25 Td [(l)-31(ines. Anal f)-28(issur)-24(e. )]TJ /T1_3 1 Tf 0 Tw [(K)17.9(olop)46.1(roctologia)]TJ /T1_2 1 Tf 0.191 Tw (. 2021;20\(4\):10\22621. \(in Russ.\). )Tj 0 Tw 0 -1.25 TD [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.33878/2073-7556-2021-20-4-10-21)Tj 0 0 0 1 k /GS1 gs 0.109 Tw -1.847 -1.25 Td (2.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Ek)-24(t)17(ov)]TJ /Span<>> BDC ( )Tj EMC [(V.N. T)50(r)-24(ea)15(tment of anal f)-28(issur)-24(es wi)-23.9(t)-13(h l)-15.9(a)15(ter)-33(al subcut)15(aneous )]TJ -0.002 Tw -1.296 -1.25 Td [(sphinc)-16(ter)-31.9(o)17(t)17(omy. A)-14(bstr)-32.9(a)-17(c)-16(t diss. cand. med. sc)-24(iences. 1984; M., 157)]TJ /Span<>> BDC ( )Tj EMC (p. )Tj 0.023 Tw T* (\(in Russ.\).)Tj -0.028 Tw T* (3.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Gar)-32(c\355a-G)20.1(r)-33(aner)-32(o)]TJ /Span<>> BDC ( )Tj EMC (E, Sanahuja)Tj /Span<>> BDC ( )Tj EMC [(A, Gar)-31.9(c\355a-Ar)-16(mengol)]TJ /Span<>> BDC ( )Tj EMC [(J, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Anal end)-16(o)]TJ 0 Tw (-)Tj 0.23 Tw -1.296 -1.25 Td [(sono)-16(gr)-33(aphic ev)-15(al)35(ua)15(t)-32(ion af)-28(ter cl)30(osed l)-16(a)15(ter)-32.9(al subcut)15(aneous sphinc)]TJ 0 Tw (-)Tj T* [(ter)-32(o)17(t)17(omy. )]TJ /T1_3 1 Tf 0.293 Tw 4.472 0 Td [(Dis Colon R)21(ectum.)]TJ /T1_2 1 Tf [( 1998;41\(5\):598\226601. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1007/)Tj -4.472 -1.25 Td (BF02235266)Tj 0 0 0 1 k /GS1 gs 0.109 Tw T* (4.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (Nelson)Tj /Span<>> BDC ( )Tj EMC (R, Manuel)Tj /Span<>> BDC ( )Tj EMC (D, Gumienny)Tj /Span<>> BDC ( )Tj EMC [(C, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. A sy)-12.9(stema)15(t)-32(ic r)-23.9(ev)-16(iew and )]TJ 0.272 Tw -1.296 -1.25 Td [(me)-12(t)15(a-anal)35.1(y)-13(sis of t)-13(he tr)-24(ea)15(tment of anal f)-28(issur)-23.9(e. )]TJ /T1_3 1 Tf [(T)54(ech Colop)46.1(roctol. )]TJ /T1_2 1 Tf 0.023 Tw T* [(2017;21\(8\):605\226625. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1007/s10151-017-1664-2)Tj 0 0 0 1 k /GS1 gs 0.147 Tw T* (5.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Bol)-16(and)]TJ /Span<>> BDC ( )Tj EMC [(P)25(A, K)25(ell)35.1(y)]TJ /Span<>> BDC ( )Tj EMC [(ME, Donl)30(on)]TJ /Span<>> BDC ( )Tj EMC [(NE, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Mana)-16.9(gement opt)-32(ions for )]TJ 0.112 Tw -1.296 -1.25 Td [(chr)-32(onic anal f)-28(issur)-23.9(e: a sy)-13(stema)15.1(t)-32(ic r)-24(ev)-16(iew of r)-33(and)-16(omized contr)-31.9(olled )]TJ 0 Tw T* [(tr)-37(ials. )]TJ /T1_3 1 Tf 0.267 Tw 2.89 0 Td [(Inter)-14(national Jour)-13.9(nal of Colorectal Disease.)]TJ /T1_2 1 Tf ( 2020;35:1807\226)Tj 0.023 Tw -2.89 -1.25 Td [(1815. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1007/s00384-020-03699-4)Tj 0 0 0 1 k /GS1 gs 0.125 Tw T* (6.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Khr)-24(yuk)-15.9(in)]TJ /Span<>> BDC ( )Tj EMC [(R.Y)35(u., Zhar)-24(kov)]TJ /Span<>> BDC ( )Tj EMC [(E.E., Gol)30(ok)-24(t)-31.9(ionov)]TJ /Span<>> BDC ( )Tj EMC [(N.A., e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. T)50(r)-23.9(ea)15(tment )]TJ 0.206 Tw -1.296 -1.25 Td [(of chr)-32(onic anal f)-28(issur)-23.9(e bo)17(tul)-30.9(inum t)17(o)14(xin t)-10(ype A 40 U in com)10(p)32(ar)-37(i)]TJ 0 Tw (-)Tj 0.008 Tc 0.35 Tw T* [(son wi)-24(t)-13.1(h l)-16.1(a)14.9(ter)-33.1(al subcut)14.9(aneous sphinc)-16(ter)-32.1(o)16.9(t)16.9(omy \(NCT03855046\).)8( )]TJ /T1_3 1 Tf 0 Tc 0 Tw T* [(K)18(olop)46(roktologia)]TJ /T1_2 1 Tf 0.039 Tw [(. 2022;21\(1\):60\22670. \(in Russ.\). )0.5(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.33878/2073-)Tj T* (7556-2022-21-1-60-70)Tj 0 0 0 1 k /GS1 gs 0.125 Tw T* (7.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (Ebinger)Tj /Span<>> BDC ( )Tj EMC [(SM, Har)-23.9(d)17(t)]TJ /Span<>> BDC ( )Tj EMC [(J, W)12.1(ar)-10(schko)-14(w)]TJ /Span<>> BDC ( )Tj EMC [(R, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Oper)-33(a)15(t)-32(i)-15.9(ve and medical )]TJ -0.001 Tw -1.296 -1.25 Td [(tr)-24(ea)15(tment of chr)-32(onic anal f)-28(issur)-24(es-a r)-24(ev)-15.9(iew and ne)-12(t)-32(w)-14(or)-24(k me)-12(t)15(a-anal)35(y)]TJ 0 Tw 27.286 0 Td (-)Tj -0.003 Tw -27.286 -1.25 Td [(sis of r)-33(and)-16(omized contr)-32(olled tr)-36.9(ials. )]TJ /T1_3 1 Tf (J Gastroenterol.)Tj /T1_2 1 Tf ( 2017;52\(6\):663\226)Tj 0.023 Tw T* [(676. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1007/s00535-017-1335-0)Tj 0 0 0 1 k /GS1 gs 0.041 Tw T* (8.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Tk)-17(al)-31(ich)]TJ /Span<>> BDC ( )Tj EMC [(O.V., P)10(onomar)-23.9(enko)]TJ /Span<>> BDC ( )Tj EMC [(A.A., F)10(omenko)]TJ /Span<>> BDC ( )Tj EMC [(O.Y)35(u., e)-11.9(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Immedia)15.1(te )]TJ 0.005 Tw -1.296 -1.25 Td [(r)-24(esul)56.1(ts of com)10(ple)-18(x tr)-24(ea)15(tment of chr)-31.9(onic anal f)-28(issur)-23.9(e using bo)17(tul)-31(inum )]TJ 0.18 Tw T* [(t)17(o)14(xin t)-9.9(ype A \(ISRCTN 97413456\). )]TJ /T1_3 1 Tf 0 Tw [(K)18(olop)46(roktologia)]TJ /T1_2 1 Tf 0.18 Tw (. 2020;19\(1\):80\226)Tj 0.023 Tw T* [(99. \(in Russ.\). d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.33878/2073-7556-2020-19-1-80-99)Tj 0 0 0 1 k /GS1 gs 0.268 Tw T* (9.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (Nelson)Tj /Span<>> BDC ( )Tj EMC [(RL. Oper)-32.9(a)15(t)-32(i)-16(ve p)25(r)-32(o)-16(cedur)-24(es for f)-27.9(issur)-24(e in ano. )]TJ /T1_3 1 Tf 0 Tw (Cochrane )Tj 0.007 Tc 0.349 Tw -1.296 -1.25 Td [(D)0.5(a)0.5(t)0.5(ab)0.5(a)0.5(s)0.5(e)0.5( S)0.5(ys)0.5(t)0.5( R)21.5(e)0.5(v)0.5(.)]TJ /T1_2 1 Tf [( 2)0.5(0)0.5(1)0.5(0;)0.5(1)0.5(1)0.5(:)0.5(Cd)0.5(0)0.5(0)0.5(2)0.5(19)0.5(9)0.5(.)0.5( d)-15.5(oi)0.5(:)]TJ /Span<>> BDC 18.909 0 Td ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs -0.007 Tw [(1)0.5(0)0.5(.1)0.5(0)0.5(0)0.5(2/)0.5(1)0.5(4)0.5(65)0.5(1)0.5(8)0.5(58)0.5(.)]TJ 0 Tc 0 Tw -18.909 -1.25 Td (CD002199.pub4)Tj 0 0 0 1 k /GS1 gs 0.15 Tw T* (10.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(K)-16(amaev)-14.9(a)]TJ /Span<>> BDC ( )Tj EMC [(Z.Z., T)34.9(i)-23.9(t)17(ovA.Y)35(u., P)10(onomar)-23.9(eenko)]TJ /Span<>> BDC ( )Tj EMC [(A.A., e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. T)47(he pl)-16(a)-17(ce )]TJ 0.094 Tw -1.796 -1.25 Td [(of dil)-16(a)15(t)15(a)15(t)-32(ion me)-11.9(t)-13(hods and l)-16(a)15(ter)-33(al subcut)15.1(aneous sphinc)-16(ter)-32(o)17(t)17(omy for )]TJ 0.079 Tw T* [(t)-13(he inter)-14.9(nal anal sphinc)-16(ter sp)32(as)26(m l)-31(iquid)42.1(a)15(t)-32(ion \(sy)-13(stema)15(t)-32(ic l)-31(i)-23.9(ter)-33(a)15(tur)-23.9(e )]TJ 0.248 Tw T* [(r)-24(ev)-15.9(iew and me)-12(t)15(a-anal)35(y)-13(ses\). )]TJ /T1_3 1 Tf 0 Tw (Chirurg)Tj /T1_2 1 Tf 0.248 Tw (. 2022;7\(8\):19\22630. \(in Russ.\). )Tj 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.33920/med-15-2204-03)Tj 0 0 0 1 k /GS1 gs -0.012 Tw -1.847 -1.25 Td (11.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(T)35(i)-24(t)17(ov)]TJ /Span<>> BDC ( )Tj EMC [(A.Y)35(u., Ba)-17(gd)42(asar)-23.9(y)22(an)]TJ /Span<>> BDC ( )Tj EMC [(S.L., Or)-30(l)30(ov)-15(a)]TJ /Span<>> BDC ( )Tj EMC [(L.P., e)-11.9(t)]TJ /Span<>> BDC ( )Tj EMC [(al. P)30(neumodi)-15.9(vulsion )]TJ 0.103 Tw -1.796 -1.25 Td [(of t)-13(he anal sphinc)-16(ter in t)-13(he sur)-32(gical tr)-23.9(ea)14.9(tment of chr)-31.9(onic anal f)-27.9(is)]TJ 0 Tw (-)Tj T* [(sur)-24(e. )]TJ /T1_3 1 Tf 2.265 0 Td [(K)18(olop)46(roctologia)]TJ /T1_2 1 Tf 0.023 Tw (. 2009;1:10\22614. \(in Russ.\).)Tj 0.052 Tw 26.79 50 Td (12.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Gul)Tj /Span<>> BDC ( )Tj EMC (T, Khan)Tj /Span<>> BDC ( )Tj EMC (MM, Khan)Tj /Span<>> BDC ( )Tj EMC [(MA, e)-11.9(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Com)10(p)32(ar)-37(ison of contr)-32(olled-inter)]TJ 0 Tw 25.49 0 Td (-)Tj 0.158 Tw -27.286 -1.25 Td [(mi)-24(t)-30(tent anal dil)-16(a)15(t)15(a)15(t)-32(ion and l)-16(a)15(ter)-33(al inter)-15(nal sphinc)-16(ter)-31.9(o)17(t)17(omy in t)-13(he )]TJ 0.049 Tw T* [(tr)-24(ea)15.1(tment of )0.5(chr)-32(onic )0.5(anal )0.5(f)-28(issur)-23.9(es: )0.5(a p)25(r)-31.9(ospec)-16(t)-32(i)-16(ve )0.5(r)-33(and)-16(omized )0.5(stud)17.1(y. )]TJ /T1_3 1 Tf 0.023 Tw T* [(P)18(ak J Surg.)]TJ /T1_2 1 Tf [( 2016;32\(4\):218\226222. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1016/j.ijsu.2009.03.006)Tj 0 0 0 1 k /GS1 gs 0.137 Tw T* (13.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Gar)-32(c)-23.9(ia-A)-25(guil)-16(ar)]TJ /Span<>> BDC ( )Tj EMC (J, Belmonte)Tj /Span<>> BDC ( )Tj EMC [(C, W)20(ong)]TJ /Span<>> BDC ( )Tj EMC [(WD, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Open vs. cl)30(osed )]TJ 0.041 Tw -1.796 -1.25 Td [(sphinc)-16(ter)-31.9(o)17(t)17(omy )0.5(for )0.5(chr)-32(onic anal )0.5(f)-27.9(issur)-24(e: )0.5(l)30(ong-ter)-16(m )0.5(r)-23.9(esul)56(ts. )]TJ /T1_3 1 Tf 24.041 0 Td [(Dis )0.5(Colon )]TJ 0 Tw -24.041 -1.25 Td [(R)21(ectum.)]TJ /T1_2 1 Tf 0.023 Tw ( 1996;39\(4\):440\226443.)Tj -0.005 Tw T* (14.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Br)-32(o)-14(wn)]TJ /Span<>> BDC ( )Tj EMC [(CJ, Dubr)-24(euil)]TJ /Span<>> BDC ( )Tj EMC [(D, Sant)17(or)-31.9(o)]TJ /Span<>> BDC ( )Tj EMC [(L, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. L)-32(a)15(ter)-32.9(al inter)-15(nal sphinc)-16(ter)]TJ 0 Tw 25.49 0 Td (-)Tj -0.031 Tw -27.286 -1.25 Td [(o)17(t)17(omy is super)-37(ior t)17(o t)17(opical ni)-24(tr)-31.9(o)-16(gl)35(ycer)-37(in for heal)-31(ing chr)-32(onic anal f)-28(is)]TJ 0 Tw (-)Tj 0.079 Tw T* [(sur)-23.9(e and d)-16(oes no)17(t com)10(p)25(r)-32(omise l)30(ong-ter)-15.9(m fecal cont)-31.9(inence: six-year )]TJ 0.181 Tw T* [(foll)30(o)-14(w-up of a mul)56.1(t)-32(icenter, r)-33(and)-16(omized, contr)-32(olled tr)-37(ial. )]TJ /T1_3 1 Tf (Dis Colon )Tj 0 Tw T* [(R)21(ectum.)]TJ /T1_2 1 Tf 0.023 Tw [( 2007;50\(4\):442\226448. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1007/s10350-006-0844-3)Tj 0 0 0 1 k /GS1 gs -0.037 Tw T* (15.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Jensen)Tj /Span<>> BDC ( )Tj EMC [(SL, L)35(und)]TJ /Span<>> BDC ( )Tj EMC (F, Nielsen)Tj /Span<>> BDC ( )Tj EMC [(OV, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. L)-32(a)15.1(ter)-33(al subcut)15(aneous sphinc)]TJ 0 Tw (-)Tj 0.04 Tw -1.796 -1.25 Td [(ter)-32(o)17(t)17(omy ver)-10(sus anal dil)-16(a)15(t)15(a)15(t)-32(ion in t)-12.9(he tr)-23.9(ea)15(tment of f)-28(issur)-23.9(e in ano in )]TJ 0.127 Tw T* [(outp)32(a)15(t)-32(ients: a p)25(r)-32(ospec)-16(t)-32(i)-16(ve r)-33(and)-16(omised stud)17(y. )]TJ /T1_3 1 Tf (Br Med)Tj /Span<>> BDC ( )Tj EMC (J.)Tj /T1_2 1 Tf [( \(Cl)-31(in. R)13(es. )]TJ 0.023 Tw T* [(Ed.\). 1984;289\(6444\):528\226530. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1136/bmj.289.6444.528)Tj 0 0 0 1 k /GS1 gs -0.032 Tw T* (16.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Bosche)-12(t)-29.9(t)17(o)]TJ /Span<>> BDC ( )Tj EMC [(S, Giov)-15(annone)]TJ /Span<>> BDC ( )Tj EMC [(M, T)45(osoni)]TJ /Span<>> BDC ( )Tj EMC [(M, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Hydr)-32(opneuma)15.1(t)-32(ic anal )]TJ 0.135 Tw -1.796 -1.25 Td [(dil)-16(a)15(t)-31.9(ion in conser)-31.9(v)-15(a)15(t)-32(i)-16(ve tr)-23.9(ea)15(tment of chr)-32(onic anal f)-28(issur)-23.9(e: cl)-31(inical )]TJ 0.229 Tw T* [(outcomes and r)-33(and)-16(omized com)10(p)32(ar)-36.9(ison wi)-24(t)-13(h t)17(opical ni)-24(tr)-31.9(o)-16(gl)35(ycer)-37(in. )]TJ /T1_3 1 Tf 0.339 Tw T* [(T)54(ech Colop)46(roctology.)]TJ /T1_2 1 Tf [( 2004;8\(2\):89\22692. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1007/s10151-004-)Tj T* (0062-8)Tj 0 0 0 1 k /GS1 gs 0.229 Tw T* (17.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(R)13(enzi)]TJ /Span<>> BDC ( )Tj EMC [(A, Iz)-24(zo)]TJ /Span<>> BDC ( )Tj EMC [(D, Di Sar)-15(no)]TJ /Span<>> BDC ( )Tj EMC [(G, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Cl)-31(inical, manome)-12(tr)-36.9(ic, and )]TJ 0.101 Tw -1.796 -1.25 Td [(ul)56(tr)-32.9(asono)-16(gr)-33(aphic r)-23.9(esul)56(ts of pneuma)15(t)-32(ic ball)30.1(o)-16(on dil)-16(a)15(t)15(a)15(t)-32(ion vs. l)-16(a)15(ter)-32.9(al )]TJ 0.041 Tw T* [(inter)-15(nal sphinc)-15.9(ter)-32(o)17(t)17(omy for chr)-32(onic anal f)-28(issur)-23.9(e: a p)25(r)-32(ospec)-16(t)-31.9(i)-16(ve, r)-33(an)]TJ 0 Tw (-)Tj 0.218 Tw T* [(d)-16(omized, contr)-32(olled tr)-37(ial. )]TJ /T1_3 1 Tf [(Dis Colon R)21(ectum.)]TJ /T1_2 1 Tf ( 2008;51\(1\):121\226127. )Tj 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1007/s10350-007-9162-7)Tj 0 0 0 1 k /GS1 gs -0.03 Tw -1.847 -1.25 Td (18.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(P)-24(insk)]TJ /Span<>> BDC ( )Tj EMC (I, Czeiger)Tj /Span<>> BDC ( )Tj EMC [(D, L)-32(ichtman)]TJ /Span<>> BDC ( )Tj EMC [(D, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. T)47(he l)30(ong-ter)-16(m ef)-56(fec)-16(t of st)15(an)]TJ 0 Tw (-)Tj 0.033 Tw -1.796 -1.25 Td [(d)42(ar)-24(dized anal dil)-16(a)15(t)15(a)15(t)-32(ion for chr)-32(onic anal f)-27.9(issur)-24(e on anal cont)-32(inence. )]TJ /T1_3 1 Tf 0.023 Tw T* [(Ann Colop)46(roctol.)]TJ /T1_2 1 Tf [( 2021;37\(2\):115\226119. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw [(10.3393/a)-17(c.2020.03.16)]TJ 0 0 0 1 k /GS1 gs 0.128 Tw T* (19.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(S)-16(hel)35(ygin)]TJ /Span<>> BDC ( )Tj EMC [(Y.A., F)10(r)-31.9(ol)30(ov)]TJ /Span<>> BDC ( )Tj EMC [(S.A., Or)-30(l)30(ov)-15(a)]TJ /Span<>> BDC ( )Tj EMC [(L.P., e)-11.9(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Immedia)15.1(te r)-24(esul)56(ts )]TJ 0.026 Tw -1.796 -1.25 Td [(of com)10(p)25(r)-24(ehensi)-15.9(ve tr)-24(ea)15.1(tment of chr)-32(onic anal f)-28(issur)-23.9(e. )]TJ /T1_3 1 Tf 0 Tw [(K)18(olop)46(roctologia)]TJ /T1_2 1 Tf (. )Tj 0.023 Tw T* (2010;1\(31\):4\2269. \(in Russ.\).)Tj -0.003 Tw T* (20.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(S)-16(hel)35(ygin)]TJ /Span<>> BDC ( )Tj EMC [(Y.A., F)10(r)-32(ol)30.1(ov)]TJ /Span<>> BDC ( )Tj EMC [(S.A., T)35(i)-24(t)17(ov)]TJ /Span<>> BDC ( )Tj EMC [(A.Y)35(u., e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Anal incont)-32(inence in )]TJ 0.112 Tw -1.796 -1.25 Td [(p)32(a)15(t)-32(ients )0.5(under)-32(going )0.5(anal )0.5(f)-28(issur)-23.9(e )0.5(e)-18(x)-13(c)-24(ision )0.5(in )0.5(combina)15(t)-31.9(ion wi)-23.9(t)-13(h )0.5(l)-16(a)15(t)]TJ 0 Tw (-)Tj 0.166 Tw T* [(er)-33(al )0.5(subcut)15(aneous )0.5(sphinc)-15.9(ter)-32(o)17(t)17(omy. )]TJ /T1_3 1 Tf 0 Tw 14.894 0 Td [(K)18(olop)46(roctologia)]TJ /T1_2 1 Tf 0.166 Tw [(. )0.5(2008;3:18\22624. )]TJ 0.023 Tw -14.894 -1.25 Td (\(in Russ.\).)Tj 0.095 Tw T* (21.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(F)-19(ischer)]TJ /Span<>> BDC ( )Tj EMC [(M, T)47(her)-15.9(mann)]TJ /Span<>> BDC ( )Tj EMC [(M, T)50(r)-31.9(obisch)]TJ /Span<>> BDC ( )Tj EMC [(M, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. T)50(r)-24(ea)15(tment of p)25(r)-36.9(imar)-24(y )]TJ 0.138 Tw -1.796 -1.25 Td [(chr)-32(onic )0.6(f)-28(issur)-24(e-in-ano )0.6(b)12(y )0.6(anal )0.5(dil)-15.9(a)15(t)15(a)15(t)-32(ion )0.6(ver)-10(sus )0.6(sphinc)-16(ter)-32(o)17(t)17(omy: )0.6(A )]TJ 0.212 Tw T* [(d)-16(ouble-bl)-30.9(ind, r)-33(and)-16(omized, contr)-32(olled tr)-36.9(ial. )]TJ /T1_3 1 Tf [(Lang)12(enbeck)-23(s Arch Chir.)]TJ /T1_2 1 Tf 0 Tw ( )Tj 0.023 Tw T* [(1976;343:35\22644. d)-15.9(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1007/BF01261568)Tj /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\033\030\031\030\213\b)-20.9(\035\231\213\233\t \021\032)50(\b)42(\032\231\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj /T1_4 1 Tf 25 0 0 25 511.9395 56.0378 Tm (51)Tj ET endstream endobj 2058 0 obj <>/Border[0 0 0]/H/N/Rect[57.2978 699.291 184.105 689.995]/Subtype/Link/Type/Annot>> endobj 2059 0 obj <>/Border[0 0 0]/H/N/Rect[233.71 639.291 263.622 629.835]/Subtype/Link/Type/Annot>> endobj 2060 0 obj <>/Border[0 0 0]/H/N/Rect[42.5197 629.291 82.2956 619.995]/Subtype/Link/Type/Annot>> endobj 2061 0 obj <>/Border[0 0 0]/H/N/Rect[128.94 599.291 222.411 589.995]/Subtype/Link/Type/Annot>> endobj 2062 0 obj <>/Border[0 0 0]/H/N/Rect[77.716 559.291 175.188 549.995]/Subtype/Link/Type/Annot>> endobj 2063 0 obj <>/Border[0 0 0]/H/N/Rect[210.894 519.291 263.622 509.835]/Subtype/Link/Type/Annot>> endobj 2064 0 obj <>/Border[0 0 0]/H/N/Rect[42.5197 509.291 116.599 499.995]/Subtype/Link/Type/Annot>> endobj 2065 0 obj <>/Border[0 0 0]/H/N/Rect[73.716 469.291 167.188 459.995]/Subtype/Link/Type/Annot>> endobj 2066 0 obj <>/Border[0 0 0]/H/N/Rect[105.44 429.291 232.247 419.995]/Subtype/Link/Type/Annot>> endobj 2067 0 obj <>/Border[0 0 0]/H/N/Rect[198.507 409.291 263.622 399.835]/Subtype/Link/Type/Annot>> endobj 2068 0 obj <>/Border[0 0 0]/H/N/Rect[42.5197 399.291 93.2315 389.995]/Subtype/Link/Type/Annot>> endobj 2069 0 obj <>/Border[0 0 0]/H/N/Rect[57.2978 349.291 145.161 339.995]/Subtype/Link/Type/Annot>> endobj 2070 0 obj <>/Border[0 0 0]/H/N/Rect[398.859 689.291 488.194 679.835]/Subtype/Link/Type/Annot>> endobj 2071 0 obj <>/Border[0 0 0]/H/N/Rect[388.894 609.291 482.366 599.835]/Subtype/Link/Type/Annot>> endobj 2072 0 obj <>/Border[0 0 0]/H/N/Rect[394.991 569.291 484.006 559.995]/Subtype/Link/Type/Annot>> endobj 2073 0 obj <>/Border[0 0 0]/H/N/Rect[425.407 529.291 496.063 519.835]/Subtype/Link/Type/Annot>> endobj 2074 0 obj <>/Border[0 0 0]/H/N/Rect[274.961 519.291 297.777 509.995]/Subtype/Link/Type/Annot>> endobj 2075 0 obj <>/Border[0 0 0]/H/N/Rect[289.739 469.291 383.21 459.995]/Subtype/Link/Type/Annot>> endobj 2076 0 obj <>/Border[0 0 0]/H/N/Rect[414.856 439.291 491.208 429.835]/Subtype/Link/Type/Annot>> endobj 2077 0 obj <>/Border[0 0 0]/H/N/Rect[347.461 329.291 417.148 319.995]/Subtype/Link/Type/Annot>> endobj 2097 0 obj <> endobj 2096 0 obj <> endobj 2095 0 obj <> endobj 2094 0 obj <> endobj 2093 0 obj <> endobj 2092 0 obj <> endobj 2091 0 obj <> endobj 2090 0 obj <> endobj 2089 0 obj <> endobj 2088 0 obj <> endobj 2087 0 obj <> endobj 2086 0 obj <> endobj 2085 0 obj <> endobj 2084 0 obj <> endobj 2083 0 obj <> endobj 2082 0 obj <> endobj 2081 0 obj <> endobj 2080 0 obj <> endobj 2079 0 obj <> endobj 2078 0 obj <> endobj 19 0 obj <> endobj 20 0 obj <> endobj 21 0 obj <> endobj 22 0 obj <> endobj 23 0 obj <> endobj 2118 0 obj <>/Font<>/ProcSet[/PDF/Text/ImageB/ImageC]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 2119 0 obj <>/Font<>/ProcSet[/PDF/Text/ImageC]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 2120 0 obj <>/Font<>/ProcSet[/PDF/Text/ImageC]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 2121 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 2122 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 2133 0 obj [2135 0 R 2136 0 R 2137 0 R 2138 0 R 2139 0 R 2140 0 R 2141 0 R 2142 0 R 2143 0 R 2144 0 R 2145 0 R 2146 0 R 2147 0 R 2148 0 R 2149 0 R 2150 0 R 2151 0 R 2152 0 R 2153 0 R] endobj 2134 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.023 Tw 10 0 0 10 70.8661 724.8299 Tm (\255\026\036\031\036\025\034\224 \017\225 \032\026\020\017\022\032\221)Tj /T1_1 1 Tf 0.286 Tw 0 -1.218 TD [(\025\026\n\026\036\r\026 )0.5(\003.\003.)]TJ /Span<>> BDC ( )Tj EMC 6.003 0 Td [(\227 )0.5(\026\f\023\017\030\026\027\021 )0.6(\022\026\235\036\007\030\t )0.5(\022\024\035\024\023\030\024\022\021\024\035\024)]TJ 0 Tw (-)Tj 0.191 Tw -6.003 -1.218 Td (\020\017\017 \205\206\207\210\211 \212\215\210 \217\204\202\203\215\210 \ \204\017\027\007\030\026\r\026 \217\024\f\f\017\017; ORCID )Tj 0 Tw T* (0000-0003-3075-3110)Tj 0.28 Tw T* (\230\017\021\024\r \202.\236.)Tj /Span<>> BDC ( )Tj EMC (\227 \007.\n.\027., \030\031\022\024\r\024\007\017\021\036\035\034 \024\021\ \007\036\035\026 \024\002\013\036\005 )Tj 0.206 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC [(\030\036\022\024\027\f\021\030\031\022\021\017\r\027\024\005 )0.5(\022\024\035\024\023\030\024\022\021\024\035\024\020\017\017 \205\206\207\ \211 \253\203\204\222\037 )]TJ 0.482 Tw 0 -1.218 TD (\022\024\035\024\023\030\024\022\021\024\035\024\020\017\017 \017\n\036\027\ \017 \202.\203. \217\t\032\017\b\273 \204\017\027\007\030\026\r\026 )Tj 0 Tw 0 -1.218 TD (\217\024\f\f\017\017; ORCID 0000-0002-1636-8075)Tj 0.34 Tw T* (\216\030\033\022\017\027 \217.\236.)Tj /Span<>> BDC ( )Tj EMC (\227 \022.\n.\027., \r\030\026\004-\022\024\035\024\023\030\024\022\021\024\ \035\024\020 \024\021\007\036)Tj 0 Tw (-)Tj 0.205 Tw T* (\035\036\027\017\016 \024\002\013\036\005 \017)Tj /Span<>> BDC ( )Tj EMC (\030\036\022\024\027\f\021\030\031\022\021\017\r\027\024\005 \022\024\035\ \024\023\030\024\022\021\024\035\024\020\017\017 )Tj 0.221 Tw T* (\205\206\207\211 \253\203\204\222\037 \022\024\035\024\023\030\024\022\021\ \024\035\024\020\017\017 \017\n\036\027\017 \202.\203. \217\t\032\017\b\273\ )Tj 0 Tw T* (\204\017\027\007\030\026\r\026 \217\024\f\f\017\017; ORCID 0000-0003-05\ 56-1782)Tj 0.229 Tw 0 -1.218 TD (\202\027\024\f\024\r \222.\221.)Tj /Span<>> BDC ( )Tj EMC (\227 \022.\n.\027., \r\030\026\004-\022\024\035\024\023\030\024\022\021\024\ \035\024\020 \024\021\007\036\035\036)Tj 0 Tw (-)Tj 0.441 Tw 0 -1.218 TD (\027\017\016 \024\002\013\036\005 \017)Tj /Span<>> BDC ( )Tj EMC (\030\036\022\024\027\f\021\030\031\022\021\017\r\027\024\005 \022\024\035\ \024\023\030\024\022\021\024\035\024\020\017\017 )Tj 0.221 Tw 23.244 15.831 Td (\205\206\207\211 \253\203\204\222\037 \022\024\035\024\023\030\024\022\021\ \024\035\024\020\017\017 \017\n\036\027\017 \202.\203. \217\t\032\017\b\273\ )Tj 0 Tw 0 -1.218 TD (\204\017\027\007\030\026\r\026 \217\024\f\f\017\017; ORCID 0000-0002-90\ 15-2600)Tj 0.148 Tw T* (\234\036\035\t\020\017\027 \236.\202.)Tj /Span<>> BDC ( )Tj EMC (\227 \007.\n.\027., \023\030\024\235\036\f\f\024\030, \026\022\026\007\036\ \n\017\022 \217\202\203, )Tj 0.193 Tw T* [(\027\026\031\004\027\t\005 \030\031\022\024\r\024\007\017\021\036\035\034\ )0.5(\205\206\207\211 \253\203\204\222\037 \022\024\035\024\023\030\024\022\021\ \024\035\024)]TJ 0 Tw (-)Tj 0.052 Tw T* (\020\017\017 \017\n\036\027\017 \202.\203. \217\t\032\017\b\273 \204\017\ \027\007\030\026\r\026 \217\024\f\f\017\017, \026\r\036\007\031\033)Tj 0 Tw (-)Tj 0.015 Tw T* [(\013\017\005 )0.5(\022\026\235\036\007\030\024\005 )0.5(\022\024\035\024\023\030\024\022\021\024\035\024\020\017\017 )0.6(\205\206\207\210\211 )0.5(\212\215\210 )0.5(\217\204\202\203\215\210 )]TJ 0 Tw 0 -1.218 TD (\204\017\027\007\030\026\r\026 \217\024\f\f\017\017; ORCID 0000-0002-84\ 80-9362)Tj /T1_0 1 Tf 0.023 Tw 0 -2.436 TD (INFORMATION ABOUT THE AUTHORS \(ORCID\))Tj /T1_1 1 Tf 0 Tw 0 -1.218 TD [(Z)10(ar)-37(ina Z. K)-15.9(amaev)-14.9(a)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0003-3075-3110)Tj T* [(Alek)-10(sandr Y)35.1(u. T)35(i)-24(t)17(ov)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0002-1636-8075)Tj T* [(R)11(oman Ju.)]TJ /Span<>> BDC ( )Tj EMC [(Khr)-23.9(yuk)-16(in)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0003-0556-1782)Tj 0 -1.218 TD [(Iv)-15(an S.)]TJ /Span<>> BDC ( )Tj EMC (Anosov)Tj /Span<>> BDC ( )Tj EMC (\227 0000-0002-9015-2600)Tj 0 -1.218 TD [(Y)35(ur)-37(i A. S)-15.9(hel)35(yigin)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0002-8480-9362)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 70.936 529.9819 Tm [(\r\031\024\034\033)48(\026)45(\024)-10(\223\033)48(\026)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0 Tc 0.151 Tw 8 0 0 8 70.8661 517.1472 Tm (1.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (\202\020\026\023\024\r)Tj /Span<>> BDC ( )Tj EMC (\204.\202., \202\035\017\036\r)Tj /Span<>> BDC ( )Tj EMC (\205.\234., \202\004\022\026\f\024\r)Tj /Span<>> BDC ( )Tj EMC (\221.\222., \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. \025\035\017\027\017\004\036\f\022\017\036 )Tj 0.034 Tc 1.208 Tw -1.296 -1.25 Td (\030\036\022\024\n\036\027\007\026\006\017\017. \202\027\026\035\034\027\ \026\016 \021\030\036\013\017\027\026. )Tj /T1_3 1 Tf -0.034 Tw [(\222\n\023\n\033\032\n\013\024\n\023\n\202\025\002.)34( )]TJ /T1_1 1 Tf 0 Tc 0.023 Tw 0 -1.25 TD [(2021,20\(4\):10\22621. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.33878/2073-7556-2021-20-4-10-2)Tj 0 0 0 1 k /GS1 gs 0.005 Tc 0.349 Tw T* (2.)Tj /Span<>> BDC 0.805 0 Td ( )Tj EMC 0.505 0 Td [(\224)0.5(\022\021\024)0.5(\r)]TJ /Span<>> BDC ( )Tj EMC [(\200)0.5(.\203)0.5(. \214)0.5(\036\004)0.5(\036\027)0.5(\017\036)0.5( \026\027)0.5(\026\035)0.5(\034\027)0.5(\t\b)0.5( \021)0.5(\030\036)0.5(\013\017)0.5(\027)0.5( \002)0.5(\024\022)0.5(\024\r)0.5(\024\005)0.5( \023)0.5(\024\007)0.5(\022\024)0.5(\032\027)0.5(\024\005)5( )]TJ 0 Tc 0.218 Tw -1.31 -1.25 Td (\f\235\017\027\022\021\036\030\024\021\024\n\017\036\005. \202\r\021\024\ \030\036\235\036\030\026\021 \007\017\f. \022\026\027\007. \n\036\007. \027\ \026\031\022. 1984; \204., )Tj 0.023 Tw T* (157 \f.)Tj -0.028 Tw T* (3.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Gar)-32(c\355a-G)20(r)-32.9(aner)-32(o)]TJ /Span<>> BDC ( )Tj EMC (E, Sanahuja)Tj /Span<>> BDC ( )Tj EMC [(A, Gar)-31.9(c\355a-Ar)-16(mengol)]TJ /Span<>> BDC ( )Tj EMC [(J, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Anal end)-16(o)]TJ 0 Tw (-)Tj 0.23 Tw -1.296 -1.25 Td [(sono)-16(gr)-33(aphic ev)-15(al)35(ua)15(t)-32(ion af)-28(ter cl)30(osed l)-16(a)15(ter)-32.9(al subcut)15(aneous sphinc)]TJ 0 Tw (-)Tj T* [(ter)-32(o)17(t)17(omy. )]TJ /T1_3 1 Tf 0.293 Tw 4.472 0 Td [(Dis Colon R)21(ectum.)]TJ /T1_1 1 Tf [( 1998;41\(5\):598\226601. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1007/)Tj -4.472 -1.25 Td (BF02235266)Tj 0 0 0 1 k /GS1 gs 0.109 Tw T* (4.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (Nelson)Tj /Span<>> BDC ( )Tj EMC (R, Manuel)Tj /Span<>> BDC ( )Tj EMC (D, Gumienny)Tj /Span<>> BDC ( )Tj EMC [(C, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. A sy)-12.9(stema)15(t)-32(ic r)-23.9(ev)-16(iew and )]TJ 0.272 Tw -1.296 -1.25 Td [(me)-12(t)15(a-anal)35.1(y)-13(sis of t)-13(he tr)-24(ea)15(tment of anal f)-28(issur)-23.9(e. )]TJ /T1_3 1 Tf [(T)54(ech Colop)46.1(roctol. )]TJ /T1_1 1 Tf 0.023 Tw T* [(2017;21\(8\):605\226625. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1007/s10151-017-1664-2)Tj 0 0 0 1 k /GS1 gs 0.147 Tw T* (5.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Bol)-16(and)]TJ /Span<>> BDC ( )Tj EMC [(P)25(A, K)25(ell)35.1(y)]TJ /Span<>> BDC ( )Tj EMC [(ME, Donl)30(on)]TJ /Span<>> BDC ( )Tj EMC [(NE, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Mana)-16.9(gement opt)-32(ions for )]TJ 0.116 Tw -1.296 -1.25 Td [(chr)-32(onic anal f)-28(issur)-23.9(e: a sy)-13(stema)15.1(t)-32(ic r)-24(ev)-15.9(iew of r)-32.9(and)-16(omised contr)-32(olled )]TJ 0 Tw T* [(tr)-37(ials. )]TJ /T1_3 1 Tf 0.267 Tw 2.89 0 Td [(Inter)-14(national Jour)-13.9(nal of Colorectal Disease.)]TJ /T1_1 1 Tf ( 2020;35:1807\226)Tj 0.023 Tw -2.89 -1.25 Td [(1815. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1007/s00384-020-03699-4)Tj 0 0 0 1 k /GS1 gs 0.067 Tw T* (6.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (\216\030\033\022\017\027)Tj /Span<>> BDC ( )Tj EMC (\217.\236., \240\026\030\022\024\r)Tj /Span<>> BDC ( )Tj EMC (\213.\213., \206\024\035\024\022\021\017\024\027\024\r)Tj /Span<>> BDC ( )Tj EMC (\203.\202., \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. \214\036\004\036\027\017\036 )Tj 0.242 Tw -1.296 -1.25 Td (\b\030\024\027\017\004\036\f\022\024\005 \026\027\026\035\034\027\024\005\ \021\030\036\013\017\027\t \f)Tj /Span<>> BDC ( )Tj EMC (\017\f\023\024\035\034\024\r\026\027\017\036\n \002\024\021\031\035\017\ \027\017\004\036)Tj 0 Tw (-)Tj 0.132 Tw T* (\f\022\024\020\024 \021\024\022\f\017\027\026 \021\017\023\026 \202)Tj /Span<>> BDC ( )Tj EMC (\r \007\024\017\030\024\r\022\036 40 \213\212 \r)Tj /Span<>> BDC ( )Tj EMC (\f\030\026\r\027\036\027\017\017 \f)Tj /Span<>> BDC ( )Tj EMC (\002\024\022\024\r\024\005 )Tj 0.201 Tw T* (\023\024\007\022\024\032\027\024\005 \f\235\017\027\022\021\036\030\024\021\ \024\n\017\036\005 \(NCT03855046\). )Tj /T1_3 1 Tf 0 Tw (\222\n\023\n\033\032\n\013\024\n\023\n\202\025\002. )Tj /T1_1 1 Tf 0.023 Tw T* [(2022;21\(1\):60\22670. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.33878/2073-7556-2022-21-1-60-70)Tj 0 0 0 1 k /GS1 gs 0.125 Tw T* (7.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (Ebinger)Tj /Span<>> BDC ( )Tj EMC [(SM, Har)-23.9(d)17(t)]TJ /Span<>> BDC ( )Tj EMC [(J, W)12(ar)-9.9(schko)-14(w)]TJ /Span<>> BDC ( )Tj EMC [(R, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Oper)-33(a)15(t)-32(i)-15.9(ve and medical )]TJ -0.001 Tw -1.296 -1.25 Td [(tr)-24(ea)15(tment of chr)-32(onic anal f)-28(issur)-24(es-a r)-24(ev)-15.9(iew and ne)-12(t)-32(w)-14(or)-24(k me)-12(t)15(a-anal)35(y)]TJ 0 Tw 27.286 0 Td (-)Tj -0.003 Tw -27.286 -1.25 Td [(sis of r)-33(and)-16(omized contr)-32(olled tr)-36.9(ials. )]TJ /T1_3 1 Tf (J Gastroenterol.)Tj /T1_1 1 Tf ( 2017;52\(6\):663\226)Tj 0.023 Tw T* [(676. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1007/s00535-017-1335-0)Tj 0 0 0 1 k /GS1 gs 0.012 Tc 0.432 Tw T* (8.)Tj /Span<>> BDC ( )Tj EMC 1.331 0 Td (\230\022\026\035\017\004)Tj /Span<>> BDC ( )Tj EMC (\210.\200., \215\024\027\024\n\026\030\036\027\022\024)Tj /Span<>> BDC ( )Tj EMC (\202.\202., \205\024\n\036\027\022\024)Tj /Span<>> BDC ( )Tj EMC (\210.\236., \017)Tj /Span<>> BDC ( )Tj EMC [(\f\024\026\r\021.)12( )]TJ 0.011 Tc 0.423 Tw -1.331 -1.25 Td (\203\036\023\024\f\030\036\007\f\021\r\036\027\027\t\036 \030\036\031\035\ \034\021\026\021\t \022\024\n\023\035\036\022\f\027\024\020\024 \035\036\ \004\036\027\017\016 \b\030\024\027\017)Tj 0 Tc 0 Tw (-)Tj 0.004 Tc 0.35 Tw T* [(\004\036\f\022\024\005 \026\027\026\035\034\027\024\005 )0.5(\021\030\036\013\017\027\t \f)]TJ /Span<>> BDC ( )Tj EMC [(\023\030\017\n\036\027\036\027\017\036\n \002\024\021\031\035\024\021\024\ \022\f\017\027\026 \021\017\023)4( )]TJ 0.014 Tc 0.511 Tw T* (\202)Tj /Span<>> BDC ( )Tj EMC 1.325 0 Td [(\(ISRCTN )0.6(97413456\). )]TJ /T1_3 1 Tf -0.014 Tw 9.669 0 Td (\222\n\023\n\033\032\n\013\024\n\023\n\202\025\002.)Tj /T1_1 1 Tf 0.511 Tw [( )0.5(2020;19\(1\):80\22699.)14( )]TJ 0 Tc 0 Tw -10.994 -1.25 Td [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.33878/2073-7556-2020-19-1-80-99)Tj 0 0 0 1 k /GS1 gs 0.268 Tw -1.847 -1.25 Td (9.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (Nelson)Tj /Span<>> BDC ( )Tj EMC [(RL. Oper)-32.9(a)15(t)-32(i)-16(ve p)25(r)-32(o)-16(cedur)-24(es for f)-27.9(issur)-24(e in ano. )]TJ /T1_3 1 Tf 0 Tw (Cochrane )Tj 0.007 Tc 0.349 Tw -1.296 -1.25 Td [(D)0.5(a)0.5(t)0.5(ab)0.5(a)0.5(s)0.5(e)0.5( S)0.5(ys)0.5(t)0.5( R)21.5(e)0.5(v)0.5(.)]TJ /T1_1 1 Tf [( 2)0.5(0)0.5(1)0.5(0;)0.5(1)0.5(1)0.5(:)0.5(Cd)0.5(0)0.5(0)0.5(21)0.5(9)0.5(9)0.5(.)0.5( d)-15.6(o)0.5(i)0.5(:)]TJ /Span<>> BDC 18.909 0 Td ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs -0.007 Tw [(1)0.5(0)0.5(.1)0.5(0)0.5(0)0.5(2/)0.5(1)0.5(4)0.5(65)0.5(1)0.5(8)0.5(58)0.5(.)]TJ 0 Tc 0 Tw -18.909 -1.25 Td (CD002199.pub4)Tj 0 0 0 1 k /GS1 gs 0.172 Tw T* (10.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (\025\026\n\026\036\r\026)Tj /Span<>> BDC ( )Tj EMC 3.864 0 Td [(\003.\003., )0.5(\230\017\021\024\r)]TJ /Span<>> BDC ( )Tj EMC 4.833 0 Td [(\202.\236., )0.5(\215\024\027\024\n\026\030\036\027\022\024)]TJ /Span<>> BDC ( )Tj EMC 8.527 0 Td [(\202.\202., )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 3.212 0 Td [(\f\024\026\r\021. )0.5(\204\036\f\021\024 )]TJ 0.012 Tw -22.232 -1.25 Td (\007\017\035\026\021\026\006\017\024\027\027\t\b \n\036\021\024\007\024\r\ \030\036\035\026\022\f\026\006\017\017 \017)Tj /Span<>> BDC ( )Tj EMC (\002\024\022\024\r\024\005 \023\024\007\022\024\032\027\024\005 \f\235\017\ \027\022)Tj 0 Tw (-)Tj 0.043 Tw T* (\021\036\030\024\021\024\n\017\017 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\035\017\022\r\017\007\026\006\017\017 \f\023\026\n\026 \r\027\031\021\030\ \036\027\027\036\020\024 \026\027\026\035\034\027\024\020\024 \f\235\017\ \027\022)Tj 0 Tw (-)Tj 0.145 Tw T* (\021\036\030\026 \(\f\017\f\021\036\n\026\021\017\004\036\f\022\017\005 \ \024\002\024\030 \035\017\021\036\030\026\021\031\030\t \017)Tj /Span<>> BDC ( )Tj EMC (\n\036\021\026\026\027\026\035\017\). )Tj /T1_3 1 Tf 0 Tw (\206\025\032\205\032\202.)Tj /T1_1 1 Tf ( )Tj 0.023 Tw T* [(2022;7\2268:19\22630. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.33920/med-15-2204-03)Tj 0 0 0 1 k /GS1 gs 0.017 Tc 0.614 Tw T* (11.)Tj /Span<>> BDC ( )Tj EMC 1.863 0 Td (\230\017\021\024\r)Tj /Span<>> BDC ( )Tj EMC (\202.\236., \207\026\020\007\026\f\026\030\016\027)Tj /Span<>> BDC ( )Tj EMC (\221.\214., \210\030\035\024\r\026)Tj /Span<>> BDC ( )Tj EMC 18.833 0 Td (\214.\215., \017)Tj /Span<>> BDC ( )Tj EMC [(\f\024\026\r\021.)17( )]TJ 0.015 Tc 0.543 Tw -20.696 -1.25 Td (\215\027\036\r\n\024\007\017\r\031\035\034\f\017\016 \026\027\026\035\034\ \027\024\020\024 \f\235\017\027\022\021\036\030\026 \023\030\017)Tj /Span<>> BDC ( )Tj EMC [(\b\017\030\031\030\020\017\004\036\f\022\024\n)15( )]TJ 0.012 Tc 0.435 Tw T* [(\035\036\004\036\027\017\017 )0.5(\b\030\024\027\017\004\036\f\022\024\005 \026\027\026\035\034\027\024\005\ \021\030\036\013\017\027\t. )]TJ /T1_3 1 Tf -0.012 Tw [(\222\n\023\n\033\032\n\013\024\n\023\n\202\025\002.)12( )]TJ /T1_1 1 Tf 0 Tc 0 Tw 29.055 51.25 Td (2009,1\(27\):10\22614.)Tj 0.052 Tw T* (12.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Gul)Tj /Span<>> BDC ( )Tj EMC (T, Khan)Tj /Span<>> BDC ( )Tj EMC (MM, Khan)Tj /Span<>> BDC ( )Tj EMC [(MA, e)-11.9(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Com)10(p)32(ar)-37(ison of contr)-32(olled-inter)]TJ 0 Tw 25.49 0 Td (-)Tj 0.158 Tw -27.286 -1.25 Td [(mi)-24(t)-30(tent anal dil)-16(a)15(t)15(a)15(t)-32(ion and l)-16(a)15(ter)-33(al inter)-15(nal sphinc)-16(ter)-31.9(o)17(t)17(omy in t)-13(he )]TJ 0.049 Tw T* [(tr)-24(ea)15.1(tment of )0.5(chr)-32(onic )0.5(anal )0.5(f)-28(issur)-23.9(es: )0.5(a p)25(r)-31.9(ospec)-16(t)-32(i)-16(ve )0.5(r)-33(and)-16(omized )0.5(stud)17.1(y. )]TJ /T1_3 1 Tf 0.023 Tw T* [(P)18(ak J Surg.)]TJ /T1_1 1 Tf [( 2016;32\(4\):218\226222. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1016/j.ijsu.2009.03.006)Tj 0 0 0 1 k /GS1 gs 0.137 Tw T* (13.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Gar)-32(c)-23.9(ia-A)-25(guil)-16(ar)]TJ /Span<>> BDC ( )Tj EMC (J, Belmonte)Tj /Span<>> BDC ( )Tj EMC [(C, W)20(ong)]TJ /Span<>> BDC ( )Tj EMC [(WD, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Open vs. cl)30(osed )]TJ 0.041 Tw -1.796 -1.25 Td [(sphinc)-16(ter)-31.9(o)17(t)17(omy )0.5(for )0.5(chr)-32(onic anal )0.5(f)-27.9(issur)-24(e: )0.5(l)30(ong-ter)-16(m )0.5(r)-23.9(esul)56(ts. )]TJ /T1_3 1 Tf 24.041 0 Td [(Dis )0.5(Colon )]TJ 0 Tw -24.041 -1.25 Td [(R)21(ectum.)]TJ /T1_1 1 Tf 0.023 Tw ( 1996;39\(4\):440\226443.)Tj -0.005 Tw T* (14.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Br)-32(o)-14(wn)]TJ /Span<>> BDC ( )Tj EMC [(CJ, Dubr)-24(euil)]TJ /Span<>> BDC ( )Tj EMC [(D, Sant)17(or)-31.9(o)]TJ /Span<>> BDC ( )Tj EMC [(L, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. L)-32(a)15(ter)-32.9(al inter)-15(nal sphinc)-16(ter)]TJ 0 Tw 25.49 0 Td (-)Tj -0.031 Tw -27.286 -1.25 Td [(o)17(t)17(omy is super)-37(ior t)17(o t)17(opical ni)-24(tr)-31.9(o)-16(gl)35(ycer)-37(in for heal)-31(ing chr)-32(onic anal f)-28(is)]TJ 0 Tw (-)Tj 0.079 Tw T* [(sur)-23.9(e and d)-16(oes no)17(t com)10(p)25(r)-32(omise l)30(ong-ter)-15.9(m fecal cont)-31.9(inence: six-year )]TJ 0.181 Tw T* [(foll)30(o)-14(w-up of a mul)56.1(t)-32(icenter, r)-33(and)-16(omized, contr)-32(olled tr)-37(ial. )]TJ /T1_3 1 Tf (Dis Colon )Tj 0 Tw T* [(R)21(ectum.)]TJ /T1_1 1 Tf 0.023 Tw [( 2007;50\(4\):442\226448. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1007/s10350-006-0844-3)Tj 0 0 0 1 k /GS1 gs -0.037 Tw T* (15.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Jensen)Tj /Span<>> BDC ( )Tj EMC [(SL, L)35(und)]TJ /Span<>> BDC ( )Tj EMC (F, Nielsen)Tj /Span<>> BDC ( )Tj EMC [(OV, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. L)-32(a)15.1(ter)-33(al subcut)15(aneous sphinc)]TJ 0 Tw (-)Tj 0.04 Tw -1.796 -1.25 Td [(ter)-32(o)17(t)17(omy ver)-10(sus anal dil)-16(a)15(t)15(a)15(t)-32(ion in t)-12.9(he tr)-23.9(ea)15(tment of f)-28(issur)-23.9(e in ano in )]TJ 0.127 Tw T* [(outp)32(a)15(t)-32(ients: a p)25(r)-32(ospec)-16(t)-32(i)-16(ve r)-33(and)-16(omised stud)17(y. )]TJ /T1_3 1 Tf (Br Med)Tj /Span<>> BDC ( )Tj EMC (J.)Tj /T1_1 1 Tf [( \(Cl)-31(in. R)13(es. )]TJ 0.023 Tw T* [(Ed.\). 1984;289\(6444\):528\226530. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1136/bmj.289.6444.528)Tj 0 0 0 1 k /GS1 gs -0.032 Tw T* (16.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Bosche)-12(t)-29.9(t)17(o)]TJ /Span<>> BDC ( )Tj EMC [(S, Giov)-15(annone)]TJ /Span<>> BDC ( )Tj EMC [(M, T)45(osoni)]TJ /Span<>> BDC ( )Tj EMC [(M, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Hydr)-32(opneuma)15.1(t)-32(ic anal )]TJ 0.135 Tw -1.796 -1.25 Td [(dil)-16(a)15(t)-31.9(ion in conser)-31.9(v)-15(a)15(t)-32(i)-16(ve tr)-23.9(ea)15(tment of chr)-32(onic anal f)-28(issur)-23.9(e: cl)-31(inical )]TJ 0.229 Tw T* [(outcomes and r)-33(and)-16(omized com)10(p)32(ar)-36.9(ison wi)-24(t)-13(h t)17(opical ni)-24(tr)-31.9(o)-16(gl)35(ycer)-37(in. )]TJ /T1_3 1 Tf 0.339 Tw T* [(T)54(ech Colop)46(roctology.)]TJ /T1_1 1 Tf [( 2004;8\(2\):89\22692. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1007/s10151-004-)Tj T* (0062-8)Tj 0 0 0 1 k /GS1 gs 0.229 Tw T* (17.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(R)13(enzi)]TJ /Span<>> BDC ( )Tj EMC [(A, Iz)-24(zo)]TJ /Span<>> BDC ( )Tj EMC [(D, Di Sar)-15(no)]TJ /Span<>> BDC ( )Tj EMC [(G, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Cl)-31(inical, manome)-12(tr)-36.9(ic, and )]TJ 0.101 Tw -1.796 -1.25 Td [(ul)56(tr)-32.9(asono)-16(gr)-33(aphic r)-23.9(esul)56(ts of pneuma)15(t)-32(ic ball)30.1(o)-16(on dil)-16(a)15(t)15(a)15(t)-32(ion vs. l)-16(a)15(ter)-32.9(al )]TJ 0.041 Tw T* [(inter)-15(nal sphinc)-15.9(ter)-32(o)17(t)17(omy for chr)-32(onic anal f)-28(issur)-23.9(e: a p)25(r)-32(ospec)-16(t)-31.9(i)-16(ve, r)-33(an)]TJ 0 Tw (-)Tj 0.218 Tw T* [(d)-16(omized, contr)-32(olled tr)-37(ial. )]TJ /T1_3 1 Tf [(Dis Colon R)21(ectum.)]TJ /T1_1 1 Tf ( 2008;51\(1\):121\226127. )Tj 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1007/s10350-007-9162-7)Tj 0 0 0 1 k /GS1 gs -0.03 Tw -1.847 -1.25 Td (18.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(P)-24(insk)]TJ /Span<>> BDC ( )Tj EMC (I, Czeiger)Tj /Span<>> BDC ( )Tj EMC [(D, L)-32(ichtman)]TJ /Span<>> BDC ( )Tj EMC [(D, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. T)47(he l)30(ong-ter)-16(m ef)-56(fec)-16(t of st)15(an)]TJ 0 Tw (-)Tj 0.033 Tw -1.796 -1.25 Td [(d)42(ar)-24(dized anal dil)-16(a)15(t)15(a)15(t)-32(ion for chr)-32(onic anal f)-27.9(issur)-24(e on anal cont)-32(inence. )]TJ /T1_3 1 Tf 0.023 Tw T* [(Ann Colop)46(roctol.)]TJ /T1_1 1 Tf [( 2021;37\(2\):115\226119. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw [(10.3393/a)-17(c.2020.03.16)]TJ 0 0 0 1 k /GS1 gs 0.018 Tc 0.645 Tw T* (19.)Tj /Span<>> BDC ( )Tj EMC 1.867 0 Td (\234\036\035\t\020\017\027)Tj /Span<>> BDC ( )Tj EMC (\236.\202., \205\030\024\035\024\r)Tj /Span<>> BDC ( )Tj EMC (\221.\202., \210\030\035\024\r\026)Tj /Span<>> BDC ( )Tj EMC (\214.\215., \017)Tj /Span<>> BDC ( )Tj EMC [(\f\024\026\r\021.)18( )]TJ 0 Tc 0.343 Tw -1.867 -1.25 Td [(\203\036\023\024\f\030\036\007\f\021\r\036\027\027\t\036 )0.6(\030\036\031\035\034\021\026\021\t )0.5(\022\024\n\023\035\036\022\f\027\024\020\024 )0.5(\035\036\004\036\027\017\016 )0.6(\b\030\024\027\017\004\036)]TJ 0 Tw (-)Tj 0.023 Tw T* (\f\022\024\005 \026\027\026\035\034\027\024\005 \021\030\036\013\017\027\ \t. )Tj /T1_3 1 Tf 0 Tw (\222\n\023\n\033\032\n\013\024\n\023\n\202\025\002. )Tj /T1_1 1 Tf 18.531 0 Td (2010;1\(31\):4\2269.)Tj 0.217 Tw -18.531 -1.25 Td (20.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (\234\036\035\t\020\017\027)Tj /Span<>> BDC ( )Tj EMC (\236.\202., \205\030\024\035\024\r)Tj /Span<>> BDC ( )Tj EMC (\221.\202., \230\017\021\024\r)Tj /Span<>> BDC ( )Tj EMC (\202.\236., \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. \202\027\026\035\034\027\024\036 )Tj 0.002 Tc 0.349 Tw -1.796 -1.25 Td (\027\036\007\036\030\032\026\027\017\036 \031)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\034\027\t\b, \023\036\030\036\027\036\f\001\017\b \017\f\f\036\ \004\036\027\017\036 \026\027\026\035\034\027\024\005 \021\030\036)Tj 0 Tc 0 Tw (-)Tj 0.011 Tc 0.398 Tw T* (\013\017\027\t \r)Tj /Span<>> BDC ( )Tj EMC (\f\024\004\036\021\026\027\017\017 \f)Tj /Span<>> BDC ( )Tj EMC [(\002\024\022\024\r\024\005 \023\024\007\022\024\032\027\024\005 \f\235\017\ \027\022\021\036\030\024\021\024\n\017\036\005.)11( )]TJ /T1_3 1 Tf 0 Tc 0 Tw T* (\222\n\023\n\033\032\n\013\024\n\023\n\202\025\002.)Tj /T1_1 1 Tf 0.023 Tw ( 2008;3\(25\):18\22624.)Tj 0.095 Tw T* (21.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(F)-19(ischer)]TJ /Span<>> BDC ( )Tj EMC [(M, T)47(her)-15.9(mann)]TJ /Span<>> BDC ( )Tj EMC [(M, T)50(r)-31.9(obisch)]TJ /Span<>> BDC ( )Tj EMC [(M, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. T)50(r)-24(ea)15(tment of p)25(r)-36.9(imar)-24(y )]TJ 0.138 Tw -1.796 -1.25 Td [(chr)-32(onic )0.6(f)-28(issur)-24(e-in-ano )0.6(b)12(y )0.6(anal )0.5(dil)-15.9(a)15(t)15(a)15(t)-32(ion )0.6(ver)-10(sus )0.6(sphinc)-16(ter)-32(o)17(t)17(omy: )0.6(A )]TJ 0.212 Tw T* [(d)-16(ouble-bl)-30.9(ind, r)-33(and)-16(omized, contr)-32(olled tr)-36.9(ial. )]TJ /T1_3 1 Tf [(Lang)12(enbeck)-23(s Arch Chir.)]TJ /T1_1 1 Tf 0 Tw ( )Tj 0.023 Tw T* [(1976;343:35\22644. d)-15.9(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1007/BF01261568)Tj /T1_4 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\033\030\031\030\213\b)-20.9(\035\231\213\233\t \021\032)50(\b)42(\032\231\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj -51.938 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 23, \023\0221)69(, 202)69(4)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 23, \023\0221)69(, 202)69(4)]TJ /T1_5 1 Tf 25 0 0 25 28.0527 56.0378 Tm (50)Tj ET endstream endobj 2135 0 obj <>/Border[0 0 0]/H/N/Rect[148.278 504.443 271.086 495.147]/Subtype/Link/Type/Annot>> endobj 2136 0 obj <>/Border[0 0 0]/H/N/Rect[262.057 444.443 291.968 434.987]/Subtype/Link/Type/Annot>> endobj 2137 0 obj <>/Border[0 0 0]/H/N/Rect[70.8661 434.443 110.642 425.147]/Subtype/Link/Type/Annot>> endobj 2138 0 obj <>/Border[0 0 0]/H/N/Rect[157.286 404.443 250.758 395.147]/Subtype/Link/Type/Annot>> endobj 2139 0 obj <>/Border[0 0 0]/H/N/Rect[106.062 364.443 203.534 355.147]/Subtype/Link/Type/Annot>> endobj 2140 0 obj <>/Border[0 0 0]/H/N/Rect[149.286 314.443 276.094 305.147]/Subtype/Link/Type/Annot>> endobj 2141 0 obj <>/Border[0 0 0]/H/N/Rect[102.062 274.443 195.534 265.147]/Subtype/Link/Type/Annot>> endobj 2142 0 obj <>/Border[0 0 0]/H/N/Rect[85.6442 224.443 212.452 215.147]/Subtype/Link/Type/Annot>> endobj 2143 0 obj <>/Border[0 0 0]/H/N/Rect[226.853 204.443 291.968 194.987]/Subtype/Link/Type/Annot>> endobj 2144 0 obj <>/Border[0 0 0]/H/N/Rect[70.8661 194.443 121.578 185.147]/Subtype/Link/Type/Annot>> endobj 2145 0 obj <>/Border[0 0 0]/H/N/Rect[143.814 144.443 231.678 135.147]/Subtype/Link/Type/Annot>> endobj 2146 0 obj <>/Border[0 0 0]/H/N/Rect[427.206 484.443 516.541 474.987]/Subtype/Link/Type/Annot>> endobj 2147 0 obj <>/Border[0 0 0]/H/N/Rect[417.241 404.443 510.712 394.987]/Subtype/Link/Type/Annot>> endobj 2148 0 obj <>/Border[0 0 0]/H/N/Rect[423.337 364.443 512.353 355.147]/Subtype/Link/Type/Annot>> endobj 2149 0 obj <>/Border[0 0 0]/H/N/Rect[453.754 324.443 524.409 314.987]/Subtype/Link/Type/Annot>> endobj 2150 0 obj <>/Border[0 0 0]/H/N/Rect[303.307 314.443 326.123 305.147]/Subtype/Link/Type/Annot>> endobj 2151 0 obj <>/Border[0 0 0]/H/N/Rect[318.085 264.443 411.557 255.147]/Subtype/Link/Type/Annot>> endobj 2152 0 obj <>/Border[0 0 0]/H/N/Rect[443.203 234.443 519.554 224.987]/Subtype/Link/Type/Annot>> endobj 2153 0 obj <>/Border[0 0 0]/H/N/Rect[375.807 124.443 445.495 115.147]/Subtype/Link/Type/Annot>> endobj 2172 0 obj <> endobj 2171 0 obj <> endobj 2170 0 obj <> endobj 2169 0 obj <> endobj 2168 0 obj <> endobj 2167 0 obj <> endobj 2166 0 obj <> endobj 2165 0 obj <> endobj 2164 0 obj <> endobj 2163 0 obj <> endobj 2162 0 obj <> endobj 2161 0 obj <> endobj 2160 0 obj <> endobj 2159 0 obj <> endobj 2158 0 obj <> endobj 2157 0 obj <> endobj 2156 0 obj <> endobj 2155 0 obj <> endobj 2154 0 obj <> endobj 2132 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\037)31(\025\001\026\002\025\007\220\002\215\016\024\013\205 \227\220\002\n\215\007\ \205\002\001\013\205 \201\220\007\013\026)11(\013\227\220\205 \220\022\f\025\n)10(\025\r\013\205 )]TJ 0 -1 TD [(\221\025\201\n)10(\025\217\001\013\205 \006\225\220\001\n)-10(\026)11(\016\002\025\026)11(\025\024\220\205 \221\002\220\022\007\016\017\016\001\220\220 \207\002\025\ \001\220\017\016\006\n\220\207 )]TJ T* [(\013\001\013\007\216\001\020\207 \026\002\016\224\220\001 \r\022\006\025\ \017\016\026)11(\013\001\220\220 \006\022\202)10(\016\024\025\002\002\025\016\024 3\2344\022\006)-10(\026)11(\013\201\220\220)]TJ 32.735 2 Td [(\021ontr)20(olled cir)31(cular dilatation and later)21.1(al subcutaneous sphincter)20(otom)21(y )]TJ 4.673 -1 Td [(for chr)20.1(onic anal f)-20.9(issur)31(es associated with h)11(emorrh)11(oids III-IV)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 10 0 0 10 42.5197 724.8299 Tm (\()Tj /T1_2 1 Tf 0.386 0 Td (\032)Tj /T1_1 1 Tf 0.016 Tc 0.052 Tw /Span<>> BDC 0.494 0 Td ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,0085\), \f\021\026\021\017\f\021\017\004\036\f\022\017 \027\026\004\017\ \n\t\036 \030\026\035\017\004\017\016 \f\024)Tj 0 Tc 0 Tw (-)Tj 0.016 Tc -0.037 Tw -0.88 -1.218 Td [(\b\030\026\027\016\035\017\f\034 )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC 5.363 0 Td [(\027\026 )0.5(7 )0.6(\f\031\021\022\017 )0.5(\023\024\f\035\036 )0.5(\024\023\036\030\026\006\017\017 )0.5(\()]TJ /T1_2 1 Tf 0 Tc 0 Tw (\032)Tj /T1_1 1 Tf 0.016 Tc -0.037 Tw /Span<>> BDC 12.345 0 Td ( )Tj EMC 0.212 0 Td (=)Tj /Span<>> BDC ( )Tj EMC 0.727 0 Td [(0,0001\).)16( )]TJ 0.191 Tw -18.647 -1.218 Td (\221\021\024\035\034 \027\026\004\017\n\024\036 \f\027\017\032\036\027\017\ \036 \031\030\024\r\027\016 \002\024\035\036\r\024\020\024 \f\017\027\007\ )Tj 0 Tc 0 Tw (-)Tj 0.016 Tc 0.297 Tw 0 -1.218 TD (\030\024\n\026, \r\036\030\024\016\021\027\024, \f\r\016\026\027\024 \f\ )Tj /Span<>> BDC ( )Tj EMC (\220\235\235\036\022\021\017\r\027\024\f\021\034\033 \035\017\022)Tj 0 Tc 0 Tw (-)Tj 0.016 Tc 0.318 Tw T* (\r\017\007\026\006\017\017 \f\235\017\027\022\021\036\030\024\f\023\026\ \n\026. \200)Tj /Span<>> BDC ( )Tj EMC [(\035\017\021\036\030\026\021\031\030\036 \021\026\022 \032\036)16( )]TJ 0.175 Tw T* [(\036\f\021\034 \007\026\027\027\t\036 \024\002 \220\235\235\036\022\021\017\ \r\027\024\n \f\027\017\032\036\027\017\017 \002\024\035\036\r\024\020\024\ )16.1( )]TJ -0.029 Tw 0 -1.218 TD (\f\017\027\007\030\024\n\026 \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \023\024\f\035\036 \023\030\017\n\036\ \027\036\027\017\016 \007\017\035\026\021\026\006\017)Tj 0 Tc 0 Tw (-)Tj 0.016 Tc 0.214 Tw 0 -1.218 TD [(\024\027\027\t\b \f\b\036\n \035\017\022\r\017\007\026\006\017\017 \f\023\ \026\f\021\017\004\036\f\022\024\020\024 \f\024\f\021\024\016\027\017\016\ )16( )]TJ 0 Tw T* (\003\202\215\025 [11,12].)Tj 0 Tc 0.158 Tw T* (\221\024\020\035\026\f\027\024 \007\026\027\027\t\n \n\027\024\032\036\f\ \021\r\026 \030\026\035\017\004\027\t\b \017\f\021\024\004\027\017\022\024\ \r )Tj 0.171 Tw T* (\035\017\021\036\030\026\021\031\030\t, \n\036\021\024\007 \207\215\221 \ \023\024\r\024\035\016\036\021 \007\024\002\017\021\034\f\016 \017\035\ \036\004\036)Tj 0 Tw (-)Tj -0.019 Tw T* (\027\017\016 \216\202\230 \031)Tj /Span<>> BDC ( )Tj EMC (85,8\22698% \023\026\006\017\036\027\021\024\r [1,6,7], \r)Tj /Span<>> BDC ( )Tj EMC (\027\026\001\036\n \017\f\f\035\036)Tj 0 Tw (-)Tj -0.035 Tw 0 -1.218 TD (\007\024\r\026\027\017\017 \026\032\017\r\035\036\027\017\016 \023\024)Tj /Span<>> BDC ( )Tj EMC (\007\026\027\027\024\005 \n\036\021\024\007\017\022\036 \031\007\026\035\ \024\f\034 \007\024)Tj 0 Tw (-)Tj -0.037 Tw 0 -1.218 TD (\f\021\017\004\034 \031)Tj /Span<>> BDC ( )Tj EMC (100% \023\026\006\017\036\027\021\024\r \r)Tj /Span<>> BDC ( )Tj EMC (\f\030\024\022\017 \027\026\002\035\033\007\036\027\017\016 45)Tj /Span<>> BDC ( )Tj EMC (\007\027\036\005. )Tj 0.201 Tw 0 -1.218 TD (\211)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \024\f\027\024\r\027\024\005 \020\030\ \031\023\023\t \f)Tj /Span<>> BDC ( )Tj EMC (\023\030\017\n\036\027\036\027\017\036\n \025\037\212 )Tj 0.175 Tw T* (\026\032\017\r\035\036\027\017\016 \r)Tj /Span<>> BDC ( )Tj EMC (\031\022\026\026\027\027\t\036 \f\030\024\022\017 \007\024\f\021\017\020\ \027\031\021\024 \031)Tj /Span<>> BDC ( )Tj EMC (85,4% )Tj 0 Tw T* (\023\026\006\017\036\027\021\024\r, \026)Tj /Span<>> BDC ( )Tj EMC (\022 65 \007\027\033)Tj /Span<>> BDC ( )Tj EMC (\227 \031)Tj /Span<>> BDC ( )Tj EMC (87,5%.)Tj 0.023 Tw T* (\200\n\036\f\021\036 \f)Tj /Span<>> BDC ( )Tj EMC (\021\036\n, \031\004\017\021\t\r\026\016 \024\021\027\024\f\017\021\036\035\ \034\027\024 \r\t\f\024\022\031\033 \004\026\f\021\024)Tj 0 Tw (-)Tj 0.116 Tw T* (\021\031 \022\035\017\027\017\004\036\f\022\024\020\024 \023\030\024\016\ \r\035\036\027\017\016 \007\017\f\235\031\027\022\006\017\017 \026\027\026\ \035\034\027\024\020\024 )Tj 0.228 Tw T* (\f\235\017\027\022\021\036\030\026, \f\027\017\032\036\027\017\036 \021\024\ \027\031\f\026 \r\027\031\021\030\036\027\027\036\020\024 \026\027\026\035\ \034\027\024)Tj 0 Tw (-)Tj 0.294 Tw T* (\020\024 \f\235\017\027\022\021\036\030\026 \023\024)Tj /Span<>> BDC ( )Tj EMC (\007\026\027\027\t\n \023\030\024\235\017\035\024\n\036\021\030\017\017 \ \031)Tj /Span<>> BDC ( )Tj EMC (41,6% )Tj 0.079 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (26,1% \024\023\036\030\017\030\024\r\026\027\027\t\b \002\024\035\034\027\ \t\b \r)Tj /Span<>> BDC ( )Tj EMC (\210\206 \017)Tj /Span<>> BDC ( )Tj EMC (\025\206, \f\024\024\021\r\036\021)Tj 0 Tw (-)Tj 0.235 Tw T* [(\f\021\r\036\027\027\024, )0.5(\026)]TJ /Span<>> BDC ( )Tj EMC 4.863 0 Td [(\021\026\022\032\036 )0.5(\007\035\017\021\036\035\034\027\024\036 )0.6(\027\036\026\032\017\r\035\036\027\017\036 )0.6(\023\024\f\035\036)]TJ 0 Tw (-)Tj 0.355 Tw -4.863 -1.218 Td (\024\023\036\030\026\006\017\024\027\027\t\b \030\026\027 \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \024\f\027\024\r\027\024\005 \020\030\ \031\023\023\t )Tj 0.211 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC (45)Tj /Span<>> BDC ( )Tj EMC (\f\031\021\022\017 \023\024\f\035\036 \024\023\036\030\026\006\017\017, \ \n\t \n\024\032\036\n \023\030\036\007\023\024\035\024)Tj 0 Tw (-)Tj 0.035 Tw T* (\032\017\021\034, \004\021\024 45 \007\027\036\005)Tj /Span<>> BDC ( )Tj EMC (\227 \027\036\007\024\f\021\026\021\024\004\027\t\005 \f\030\024\022 \007\ \035\016 \026\022\035\033)Tj 0 Tw (-)Tj T* (\004\017\021\036\035\034\027\024\005 \024\006\036\027\022\017 \030\036\031\ \035\034\021\026\021\024\r \035\036\004\036\027\017\016.)Tj 0.14 Tw T* [(\215\024 )0.5(\007\026\027\027\t\n )0.5(\035\017\021\036\030\026\021\031\030\t, )0.5(\004\026\f\021\024\021\026 )0.6(\030\026\r\017\021\017\016 )0.5(\023\024\f\035\036\024\023\036)]TJ 0 Tw (-)Tj 0.346 Tw T* (\030\026\006\017\024\027\027\024\005 \203\202\221 \023\024\f\035\036 \023\ \030\017\n\036\027\036\027\017\016 \207\215\221 \007\024\f\021\017\020\026\ \036\021 )Tj 0.145 Tw T* (30,3% [13], \023\024)Tj /Span<>> BDC ( )Tj EMC (\007\030\031\020\017\n \017\f\021\024\004\027\017\022\026\n, \n\024\032\036\ \021 \007\024\f\021\017\020\026\021\034 )Tj 0.433 Tw T* (67% [14], \r)Tj /Span<>> BDC ( )Tj EMC (\f\024\r\030\036\n\036\027\027\024\005 \035\017\021\036\030\026\021\031\030\ \036 \024\023\017\f\t\r\026\033\021 )Tj 0.324 Tw T* (9,4\22611,4% [5\2267]. \215\030\017)Tj /Span<>> BDC ( )Tj EMC [(\023\030\017\n\036\027\036\027\017\017 )0.5(\007\017\035\026\021\026\006\017\024\027\027\t\b )]TJ -0.03 Tw T* [(\n\036\021\024\007\024\r \035\036\004\036\027\017\016 \f\023\026\f\021\017\ \004\036\f\022\024\020\024 )0.5(\f\024\f\021\024\016\027\017\016 \n\t\001\036\004\027\t\b )]TJ 0.082 Tw T* (\f\021\030\031\022\021\031\030 \003\202\215\025 \004\026\f\021\024\021\026\ \007\026\027\027\024\020\024 \024\f\035\024\032\027\036\027\017\016, \023\ \024)Tj /Span<>> BDC ( )Tj EMC (\007\026\027)Tj 0 Tw (-)Tj 0.227 Tw T* (\027\t\n \035\017\021\036\030\026\021\031\030\t, \f\024\f\021\026\r\035\016\ \036\021 35,7% [15], \024\007\027\026\022\024 \f\024 )Tj 0.153 Tw T* (\r\030\036\n\036\027 \017\f\023\024\035\034\024\r\026\027\017\016 \027\036\ \022\024\027\021\030\024\035\017\030\031\036\n\t\b \f\023\024\f\024\002\024\ \r )Tj 0.124 Tw T* (\007\017\035\026\021\026\006\017\017 \026\027\026\035\034\027\024\020\024\ \f\235\017\027\022\021\036\030\026 \007\026\027\027\t\005 \n\036\021\024\ \007 \023\030\036)Tj 0 Tw (-)Tj 0.203 Tw T* (\021\036\030\023\036\035 \n\027\024\032\036\f\021\r\024 \021\036\b\027\017\ \004\036\f\022\017\b \017\n\036\027\036\027\017\005, \027\026\023\030\026\ \r)Tj 0 Tw (-)Tj 0.059 Tw T* (\035\036\027\027\t\b \027\026)Tj /Span<>> BDC ( )Tj EMC (\031\f\024\r\036\030\001\036\027\f\021\r\024\r\026\027\017\036 \n\036\021\ \024\007\017\022\017 \007\017\035\026\021\026\006\017\017 )Tj 0.039 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\007\024\f\021\017\032\036\027\017\016 \002\024\035\036\036 \013\026\007\ \016\013\036\020\024 \r\024\007\036\005\f\021\r\017\016 \027\026)Tj /Span<>> BDC ( )Tj EMC (\021\022\026\027\017 )Tj 0.002 Tw T* (\003\202\215\025, \017,)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\017\n \024\002\030\026\024\n, \031\007\026\035\024\f\034 \f\ \027\017\017\021\034 \220\021\024\021 \023\024\022\026\026)Tj 0 Tw (-)Tj -0.043 Tw T* (\021\036\035\034 \007\024)Tj /Span<>> BDC ( )Tj EMC (0% \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\f\030\024\022\026\b \027\026\002\035\033\007\036\027\017\016 \024\021 6\ \007\024)Tj /Span<>> BDC ( )Tj EMC (24 \n\036\f\016\006\036\r )Tj 0.136 Tw T* ([16\22618]. \200)Tj /Span<>> BDC ( )Tj EMC (\021\024 \032\036 \r\030\036\n\016, \r)Tj /Span<>> BDC ( )Tj EMC (\f\024\r\030\036\n\036\027\027\024\005 \035\017\021\036\030\026\021\031\030\ \036, )Tj 0.483 Tw T* [(\023\024\f\r\016\013\036\027\027\024\005 )0.6(\023\030\017\n\036\027\036\027\017\033 )0.6(\022\024\027\021\030\024\035\017\030\031\036\n\024\005 )0.5(\023\027\036\r)]TJ 0 Tw (-)Tj 0.206 Tw T* (\n\024\007\017\r\031\035\034\f\017\017, \004\026\f\021\024\021\026 \030\026\ \r\017\021\017\016 \203\202\221 \007\024\f\021\017\020\026\035\026 41% \ )Tj 0.138 Tw T* ([18] \023\030\017)Tj /Span<>> BDC ( )Tj EMC [(\f\030\024\022\026\b \027\026\002\035\033\007\036\027\017\016 )0.5(2 \n\036\f\016\006\026. \221\021\024\035\034 \r\t\f\024)]TJ 0 Tw (-)Tj 0.026 Tw T* [(\022\026\016 )0.5(\004\026\f\021\024\021\026 )0.5(\030\026\r\017\021\017\016 )0.5(\007\026\027\027\024\020\024 )0.5(\024\f\035\024\032\027\036\027\017\016, )0.6(\r\036\030\024\016\021\027\024, )]TJ 0.53 Tw T* (\f\r\016\026\027\026 \f)Tj /Span<>> BDC ( )Tj EMC (\027\036\007\024\f\021\026\021\024\004\027\024 \017\027\007\017\r\017\007\ \031\026\035\017\017\030\024\r\026\027\027\t\n )Tj 0.037 Tw T* (\023\024\007\b\024\007\024\n, \017, \022\026\022 \f\035\036\007\f\021\r\017\ \036, \004\030\036\n\036\030\027\t\n \r\024\007\036\005\f\021\r\017)Tj 0 Tw (-)Tj 0.131 Tw T* (\036\n \027\026)Tj /Span<>> BDC ( )Tj EMC (\021\022\026\027\017 \003\202\215\025. \200)Tj /Span<>> BDC ( )Tj EMC (\027\026\001\036\n \017\f\f\035\036\007\024\r\026\027\017\017 \f)Tj /Span<>> BDC ( )Tj EMC (\023\030\017\n\036)Tj 0 Tw (-)Tj 0.193 Tw T* (\027\036\027\017\036\n \023\030\036\007\035\024\032\036\027\027\024\005 \ \027\026\n\017 \n\036\021\024\007\017\022\017 \025\037\212 \004\026\f\021\ \024\021\026 )Tj 0.142 Tw T* (\030\026\r\017\021\017\016 \021\030\026\027\017\021\024\030\027\024\005\ \203\202\221 \f\024\f\021\026\r\017\035\026 35,4%, \026)Tj /Span<>> BDC ( )Tj EMC (\023\030\017 )Tj -0.01 Tw T* (\017\f\023\024\035\034\024\r\026\027\017\017 \207\215\221)Tj /Span<>> BDC ( )Tj EMC (\227 30,4% \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\f\030\024\022\026\b \027\026\002\035\033\007\036\027\017\016 )Tj 0 Tw T* (45 \007\027\036\005.)Tj 0.004 Tc 0.086 Tw 23.244 64.543 Td (\215\024 \024\002\013\036\005 \004\026\f\021\024\021\036 \030\026\r\017\ \021\017\016 \023\024\f\035\036\024\023\036\030\026\006\017\024\027\027\t\ \b \024\f)Tj 0 Tc 0 Tw (-)Tj 0.004 Tc 0.053 Tw T* (\035\024\032\027\036\027\017\005 \r)Tj /Span<>> BDC ( )Tj EMC [(\f\030\026\r\027\017\r\026\036\n\t\b \020\030\031\023\023\026\b \021\026\ \022 \032\036 \023\024\035\031\004\036\027\t)4( )]TJ 0.035 Tw T* (\f\024\023\024\f\021\026\r\017\n\t\036 \030\036\031\035\034\021\026\021\ \t \()Tj /T1_2 1 Tf 0 Tc 0 Tw (\032)Tj /T1_1 1 Tf 0.004 Tc 0.035 Tw /Span<>> BDC 11.946 0 Td ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,2\), \024\007\027\026\022\024 \021\026\022\024\036 \024\f)Tj 0 Tc 0 Tw (-)Tj 0.004 Tc 0.25 Tw -11.946 -1.218 Td (\035\024\032\027\036\027\017\036, \022\026\022 \020\036\n\026\021\024\n\026\ \023\030\024\n\036\032\027\024\f\021\017, \f\021\026\021\017\f\021\017\004\ \036)Tj 0 Tc 0 Tw (-)Tj 0.004 Tc 0.127 Tw T* (\f\022\017 \004\026\013\036 \030\026\r\017\r\026\035\024\f\034 \023\024\ \f\035\036 \207\215\221 \()Tj /T1_2 1 Tf 0 Tc 0 Tw (\032)Tj /T1_1 1 Tf 0.004 Tc 0.127 Tw /Span<>> BDC 15.447 0 Td ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC [(0,014\); \027\026\001\017)4( )]TJ 0.283 Tw -15.447 -1.218 Td (\030\036\031\035\034\021\026\021\t \027\026\b\024\007\016\021 \023\024\007\ \021\r\036\030\032\007\036\027\017\036 \r)Tj /Span<>> BDC ( )Tj EMC (\007\030\031\020\017\b \022\035\017)Tj 0 Tc 0 Tw (-)Tj 0.004 Tc 0.128 Tw 0 -1.218 TD [(\027\017\004\036\f\022\017\b \017\f\f\035\036\007\024\r\026\027\017\016\b\ , \020\007\036 \031\022\026\t\r\026\036\021\f\016, \004\021\024 \030\017\ \f\022)4( )]TJ 0.186 Tw 0 -1.218 TD (\030\026\r\017\021\017\016 \020\036\n\026\021\024\n\t \023\030\024\n\036\ \032\027\024\f\021\017 \f\r\016\026\027 \027\036\023\024\f\030\036\007)Tj 0 Tc 0 Tw (-)Tj 0.004 Tc 0.154 Tw T* (\f\021\r\036\027\027\024 \f)Tj /Span<>> BDC ( )Tj EMC [(\024\f\024\002\036\027\027\024\f\021\016\n\017 \021\036\b\027\017\022\017\ \r\t\023\024\035\027\036\027\017\016 \207\215\221)4( )]TJ -0.004 Tw T* ([6,21].)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 275.0305 578.6938 Tm [(\020)21(\026\027\r\242\224\034\022\031\034)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0 Tc 0.14 Tw 10 0 0 10 274.9606 554.3378 Tm (\204\036\021\024\007 \025\037\212 \f\024\023\024\f\021\026\r\017\n \f)Tj /Span<>> BDC ( )Tj EMC (\n\036\021\024\007\024\n \207\215\221 \r)Tj /Span<>> BDC ( )Tj EMC (\220\235\235\036\022\021\017\r)Tj 0 Tw (-)Tj 0.413 Tw T* (\027\024\f\021\017 \035\017\022\r\017\007\026\006\017\017 \f\023\026\n\026\ \r\027\031\021\030\036\027\027\036\020\024 \026\027\026\035\034\027\024\ \020\024 )Tj 0.079 Tw T* (\f\235\017\027\022\021\036\030\026 \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \027\026)Tj /Span<>> BDC ( )Tj EMC (45 \f\031\021\022\017 \023\024\f\035\036 \024\023\036\030\026\006\017\017\ , )Tj 0.212 Tw T* (\026)Tj /Span<>> BDC ( )Tj EMC (\023\024\035\024\032\017\021\036\035\034\027\026\016 \007\017\027\026\n\017\ \022\026 \r)Tj /Span<>> BDC ( )Tj EMC (\024\021\027\024\001\036\027\017\017 \023\024\022\026\026\021\036)Tj 0 Tw (-)Tj 0.317 Tw T* [(\035\036\005 \r\027\031\021\030\017\026\027\026\035\034\027\024\020\024 \ )0.5(\007\026\r\035\036\027\017\016 \023\024\r\024\035\016\036\021 \023\030\036\ \007\023\024)]TJ 0 Tw (-)Tj 0.009 Tw T* (\035\024\032\017\021\034, \004\021\024 \023\030\024\007\036\n\024\027\f\021\ \030\017\030\024\r\026\027\027\024\036 \f\027\017\032\036\027\017\036 \021\ \024\027\031\f\026 )Tj 0.228 Tw T* (\r\027\031\021\030\036\027\027\036\020\024 \026\027\026\035\034\027\024\020\ \024 \f\235\017\027\022\021\036\030\026 \027\026)Tj /Span<>> BDC ( )Tj EMC (45 \f\031\021\022\017 \023\024)Tj 0 Tw (-)Tj 0.331 Tw T* [(\f\035\036\024\023\036\030\026\006\017\024\027\027\024\020\024 )0.6(\023\036\030\017\024\007\026 )0.5(\024\002\030\026\021\017\n\024. )0.6(\003\026\032\017\r\035\036\027\017\036 )]TJ 0.155 Tw T* (\007\024\f\021\017\020\027\031\021\024 \031)Tj /Span<>> BDC ( )Tj EMC (87,5% \023\030\017)Tj /Span<>> BDC ( )Tj EMC [(\f\030\024\022\036 \027\026\002\035\033\007\036\027\017\016 )0.5(65 \007\027\036\005 )]TJ 0.017 Tw T* (\031)Tj /Span<>> BDC ( )Tj EMC 0.694 0 Td [(\023\026\006\017\036\027\021\024\r )0.6(\f)]TJ /Span<>> BDC ( )Tj EMC 5.258 0 Td [(\023\030\017\n\036\027\036\027\017\036\n )0.6(\025\037\212 )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC 8.633 0 Td [(\031 )0.6(100% )0.5(\023\026\006\017\036\027\021\024\r )]TJ 0.1 Tw -14.585 -1.218 Td (\f)Tj /Span<>> BDC ( )Tj EMC (\023\030\017\n\036\027\036\027\017\036\n \207\215\221. \215\024)Tj /Span<>> BDC ( )Tj EMC (\004\026\f\021\024\021\036 \030\026\r\017\021\017\016 \023\024\f\035\036\ \024\023\036)Tj 0 Tw (-)Tj 0.304 Tw T* (\030\026\006\017\024\027\027\t\b \024\f\035\024\032\027\036\027\017\005,\ \r)Tj /Span<>> BDC ( )Tj EMC (\021\024\n \004\017\f\035\036 \022\035\017\027\017\004\036\f\022\017\b )Tj 0.121 Tw T* (\023\030\024\016\r\035\036\027\017\005 \021\030\026\027\017\021\024\030\ \027\024\005 \203\202\221 \021\026\022 \032\036 \023\024\035\031\004\036\ \027\t \f\024)Tj 0 Tw (-)Tj 0.147 Tw T* (\023\024\f\021\026\r\017\n\t\036 \030\036\031\035\034\021\026\021\t. \230\ \026\022\017\n \024\002\030\026\024\n, \r)Tj /Span<>> BDC ( )Tj EMC (\026\022\035\033\004\036)Tj 0 Tw (-)Tj 0.084 Tw T* (\027\017\036 \027\026\001\036\020\024 \017\f\f\035\036\007\024\r\026\027\ \017\016, \f\035\036\007\031\036\021 \007\024\002\026\r\017\021\034 \024\ )Tj /Span<>> BDC ( )Tj EMC (\027\036\024\002)Tj 0 Tw (-)Tj 0.209 Tw T* (\b\024\007\017\n\024\f\021\017 \007\026\035\034\027\036\005\001\036\020\024\ \n\024\027\017\021\024\030\017\027\020\026 \023\026\006\017\036\027\021\ \024\r \f\024 )Tj 0.002 Tw T* (\f\027\017\032\036\027\017\036\n \021\024\027\031\f\026 \r\027\031\021\030\ \036\027\027\036\020\024 \026\027\026\035\034\027\024\020\024 \f\235\017\ \027\022\021\036\030\026 )Tj -0.038 Tw T* (\007\035\016 \024\002\255\036\022\021\017\r\027\024\005 \024\006\036\027\ \022\017 \235\031\027\022\006\017\024\027\026\035\034\027\024\020\024 \f\ \024\f\021\024\016\027\017\016 )Tj 0.187 Tw T* (\003\202\215\025 \017)Tj /Span<>> BDC ( )Tj EMC (\022\035\017\027\017\004\036\f\022\024\020\024 \f\024\f\021\024\016\027\017\ \016 \023\026\006\017\036\027\021\024\r \r)Tj /Span<>> BDC ( )Tj EMC (\024\021\007\026)Tj 0 Tw (-)Tj T* (\035\036\027\027\t\036 \f\030\024\022\017 \027\026\002\035\033\007\036\027\ \017\016.)Tj /T1_4 1 Tf 0.023 Tw 0 -2.436 TD (\223\030\032\255\020\034\036 \032\026\020\017\022\017\026)Tj /T1_1 1 Tf 0.337 Tw 0 -1.218 TD [(\025)-4.1(\024)-4.3(\027)1.7(\006)-6(\036)-6.8(\023)2.2(\006)-6(\017)-5.4(\016 \017)]TJ /Span<>> BDC ( )Tj EMC [(\007)-6(\017)2.7()-9.9(\026\005)1.7(\027 \017)-2.4(\f)3.1(\f)-38.9(\035)-6.8(\036)-19(\007)-4.4(\024)-4.3(\r)-8.9(\026\027)1.7(\017)-5.5(\016)13.7(:)]TJ /T1_2 1 Tf -0.028 Tc 0.365 Tw [( \222)-11.9(\026)-26.3(\003)-21.1(\026)-27.1(\031)-21.4(\027)-25.9(\026)]TJ /Span<>> BDC 19.897 0 Td ( )Tj EMC [(\221.)-24.3(\221.)-20.1(,)-28( )]TJ -0.027 Tc 0.027 Tw -19.897 -1.218 Td [(\220)25.8(\025)-19.3(\024)-23(\n)-17.3(\027)]TJ /Span<>> BDC 2.519 0 Td ( )Tj EMC [(\201)-29.3(.)0.5(\223.)-19.1(,)-27( \231)-15.8(\031)-47.6(\023)-19.7(\020)-11.9(\202)-17(\025)-19.8(\021)]TJ /Span<>> BDC 6.248 0 Td ( )Tj EMC [(\223.)-19.7(\201)-29.2(.)]TJ /T1_1 1 Tf 0 Tc 0 Tw -8.767 -1.218 Td [(\221)-4.6(\002)-9.9(\024)0.7(\030 \017)]TJ /Span<>> BDC ( )Tj EMC [(\024)-11.8(\002)3(\030)-11.3(\026)-6.4(\002)-9.9(\024)-10.8(\021)-17.7(\022)-19.1(\026 \n)1.3(\026)-11.8(\021)-9.9(\036)-1.7(\030)-7.6(\017)-0.6(\026)-33.1(\035\026)3.7(:)]TJ /T1_2 1 Tf -0.028 Tc 0.028 Tw [( \222)-11.8(\026)-26.3(\003)-21.1(\026)-27.1(\031)-21.4(\027)-25.9(\026)]TJ /Span<>> BDC 15.908 0 Td ( )Tj EMC [(\221.)-24.3(\221.)]TJ /T1_1 1 Tf 0.018 Tc -0.021 Tw -15.908 -1.218 Td [(\221)35.2(\021)-3.5(\026)6.2(\021\017)15.6(\f)-18(\021\017)22.5(\004)9.8(\036)7.6(\f)16.4(\022)-1.1(\026)-3(\016)18( )0.5(\024)6.2(\002)21(\030)6.6(\026)11.7(\002)8.1(\024)7.1(\021\022)-1(\026)21.7(:)]TJ /T1_2 1 Tf -0.007 Tc 0.004 Tw 11.346 0 Td [( )0.5(\206)-3.5(\032)-1.6(\007)-1.7(\013)5.7(\025\021)]TJ /Span<>> BDC 3.254 0 Td ( )Tj EMC 0.229 0 Td [(\212)86.9(.)20.5(\223)19.6(.)0.8(,)-7( )0.5(\222)9.1(\026)-5.3(\003\026)-6.1(\031\027)-4.9(\026)]TJ /Span<>> BDC 5.604 0 Td ( )Tj EMC 0.229 0 Td [(\221)20.6(.)-3.3(\221)20.6(.)]TJ /T1_1 1 Tf 0.002 Tc -0.002 Tw -20.663 -1.218 Td [(\203)7.2(\026\023)4.2(\017\f)-10.8(\026)1.7(\027)3.7(\017)-6.7(\036)2.1( \021)-7.9(\036)-3.4(\022\f)-34(\021)-19.5(\026)5.7(:)]TJ /T1_2 1 Tf 0 Tc 0 Tw 7.694 0 Td [( \222)16.1(\026)1.7(\003)6.9(\026)1(\031)6.6(\027)2.1(\026)]TJ /Span<>> BDC ( )Tj EMC [(\221)27.6(.)3.7(\221)27.6(.)7.9(, \201)9.3(\021)3.8(\n)-0.8(\t)9.8(\n)9.6(\027)]TJ /Span<>> BDC ( )Tj EMC [(\215)28.9(.)43.7(\207)-2.1(.)]TJ /T1_1 1 Tf -7.694 -1.218 Td [(\217)5.5(\036)-19(\007)-20.1(\026\022)-32.6(\021)-17.7(\017)1.5(\030)-11.8(\024)-4.4(\r)-8.8(\026\027)1.8(\017)-8.7(\036)6.5(:)]TJ /T1_2 1 Tf 1.221 Tw [( \201)9.3(\021)3.8(\n)-0.8(\t)9.8(\n)9.7(\027)]TJ /Span<>> BDC ( )Tj EMC [(\215)28.8(.)43.7(\207)-2.1(.)7.8(, \220)52.8(\025)7.8(\024)4(\n)9.6(\027)]TJ /Span<>> BDC ( )Tj EMC [(\201)-2.3(.)27.5(\223)26.6(.)7.8(, )]TJ -0.007 Tc 0.007 Tw T* [(\231)4.2(\031)-27.6(\023\020)8.1(\202)3(\025\021)]TJ /Span<>> BDC 3.737 0 Td ( )Tj EMC [(\223)19.6(.\201)-9.3(.)]TJ /T1_4 1 Tf 0 Tc 0.023 Tw -3.737 -2.436 Td (AUTHORS CONTRIBUTION)Tj /T1_1 1 Tf 0.141 Tw T* [(C)-6.5(o)0.8(nce)-0.7(p)-12.3(t a)2.4(n)-4.6(d d)-5.5(e)-13.3(s)-16.6(i)3.2(g)1.2(n o)-2.2(f t)-16.7(h)-5.3(e s)-20(t)-12.8(ud)-10.9(y)-11.8(:)]TJ /T1_2 1 Tf [( Z)5.6(ar)-35.3(i)8.4(n)4.8(a)]TJ /Span<>> BDC ( )Tj EMC [(Z)4(.)]TJ /Span<>> BDC ( )Tj EMC [(K)12.9(a)-0.8(m)4.3(a)-4.5(e)-4(v)10.8(a)-14(, )]TJ 0 Tw T* [(A)3.6(l)4.8(ek)-17.5(s)7.8(a)-0.8(n)-0.6(d)5.3(r)]TJ /Span<>> BDC ( )Tj EMC [(Y)33.7(u)7.7(. T)-2.7(i)0.9(t)1.5(o)-0.6(v)33.6(, Y)33.7(u)6.1(r)-35.3(i)]TJ /Span<>> BDC ( )Tj EMC [(A)-12.6(.)]TJ /Span<>> BDC ( )Tj EMC [(S)15.3(h)1.9(e)-1.9(l)11(y)3(g)-14.5(i)8.4(n)]TJ /T1_1 1 Tf 1.014 Tw T* [(C)-6.5(o)-5.8(l)-19(l)-14.3(e)-9.4(c)-32.5(t)-37.3(i)3.2(o)0.8(n )0.5(a)2.4(n)-4.6(d )0.6(p)-3.8(r)-6(o)-7(ce)-13.3(s)-12.8(s)-16.6(i)7.1(n)-1.9(g )0.6(o)-2.2(f )0.6(t)-16.7(h)-5.3(e )0.5(m)1.8(a)-8.4(t)-15.1(e)-2.1(r)-48(i)5.1(a)-1.5(l)-22.5(:)]TJ /T1_2 1 Tf 0 Tw ( )Tj T* [(Z)5.6(ar)-35.3(i)8.5(n)4.8(a)]TJ /Span<>> BDC ( )Tj EMC [(Z)4(.)]TJ /Span<>> BDC ( )Tj EMC [(K)12.8(a)-0.8(m)4.4(a)-4.5(e)-4(v)10.8(a)]TJ /T1_1 1 Tf -0.007 Tc 1.191 Tw T* [(St)-34.7(a)-15.4(t)-44.4(i)-4.3(s)-27(t)-44.4(i)-1.8(c)-18.8(a)-8.5(l)-7( p)-10.8(r)-13(o)-14(c)-6.8(e)-20.3(s)-19.8(s)-23.6(in)-8.9(g)2(:)]TJ /T1_2 1 Tf 0 Tc 1.184 Tw 10.272 0 Td [( R)7.2(om)4.3(a)-0.8(n)]TJ /Span<>> BDC ( )Tj EMC [(Y)33.8(u)7.7(. K)0.7(h)6.2(r)-40.1(y)3.8(u)4.6(k)-18.5(i)8.4(n)-6(, )]TJ 0 Tw -10.272 -1.218 Td [(Z)5.6(ar)-35.3(i)8.5(n)4.8(a)]TJ /Span<>> BDC ( )Tj EMC [(Z)4(.)]TJ /Span<>> BDC ( )Tj EMC [(K)12.8(a)-0.8(m)4.4(a)-4.5(e)-4(v)10.8(a)]TJ /T1_1 1 Tf T* [(W)3.1(r)-48(i)-6(t)-37.4(i)7.1(n)-1.9(g o)-2.2(f t)-16.7(h)-5.3(e t)-15.2(e)-23.9(x)-36(t)-20(:)]TJ /T1_2 1 Tf [( Z)5.6(ar)-35.3(i)8.4(n)4.8(a)]TJ /Span<>> BDC ( )Tj EMC [(Z)4.1(.)]TJ /Span<>> BDC ( )Tj EMC [(K)12.8(a)-0.8(m)4.3(a)-4.5(e)-3.9(v)10.8(a)-14(, I)14(v)10.8(a)-0.8(n)]TJ /Span<>> BDC ( )Tj EMC [(S)2.1(.)]TJ /Span<>> BDC ( )Tj EMC [(A)3.8(n)2(o)3.3(s)4.9(o)-0.6(v)]TJ /T1_1 1 Tf 0.006 Tc -0.006 Tw T* [(E)11.6(dit)-31.4(i)13.1(n)4.1(g)15(:)]TJ /T1_2 1 Tf 0 Tc 0.829 Tw 3.238 0 Td [( I)14(v)10.9(a)-0.8(n)]TJ /Span<>> BDC ( )Tj EMC [(S)2.1(.)]TJ /Span<>> BDC ( )Tj EMC [(A)3.8(n)1.9(o)3.3(s)4.9(o)-0.6(v)33.6(, A)3.6(l)4.8(ek)-17.5(s)7.8(a)-0.8(n)-0.6(d)5.2(r)]TJ /Span<>> BDC ( )Tj EMC [(Y)33.7(u)7.7(. T)-2.6(i)0.9(t)1.4(o)-0.6(v)33.6(, )]TJ 0 Tw -3.238 -1.218 Td [(Y)33.7(u)6.1(r)-35.3(i)]TJ /Span<>> BDC ( )Tj EMC [(A)-12.5(.)]TJ /Span<>> BDC ( )Tj EMC [(S)15.3(h)1.9(e)-1.9(l)11(y)3(g)-14.5(i)8.4(n)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\033\030\031\030\213\b)-20.9(\035\231\213\233\t \021\032)50(\b)42(\032\231\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj /T1_5 1 Tf 25 0 0 25 512.927 56.0378 Tm (49)Tj ET endstream endobj 2129 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 70.936 566.5159 Tm [(\037\036)10(\032\223\212\226\034\022\031\034)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0 Tc 0.338 Tw 10 0 0 10 70.8661 542.1599 Tm [(\215\030\017 \024\006\036\027\022\036 \030\036\031\035\034\021\026\021\024\ \r )0.5(\024\002\255\036\022\021\017\r\027\024\020\024 \024\002\f\035\036\007\024\ \r\026)]TJ 0 Tw (-)Tj 0.029 Tw 0 -1.218 TD (\027\017\016 \235\031\027\022\006\017\024\027\026\035\034\027\024\020\024\ \f\024\f\021\024\016\027\017\016 \003\202\215\025 \r\t\016\r\035\036\027\ \024, \004\021\024 )Tj 0.179 Tw T* (\n\036\021\024\007 \025\037\212 \024\022\026\t\r\026\036\021 \002\024\035\ \036\036 \f\031\013\036\f\021\r\036\027\027\024\036 \r\035\017\016\027\017\ \036 )Tj 0.378 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC (\r\027\031\021\030\036\027\027\017\005 \017)Tj /Span<>> BDC ( )Tj EMC (\027\026\030\031\032\027\t\005 \026\027\026\035\034\027\t\036 \f\235\017\ \027\022\021\036\030\t )Tj 0.17 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC (7)Tj /Span<>> BDC ( )Tj EMC (\f\031\021\022\017 \023\024\f\035\036 \024\023\036\030\026\006\017\017. \ \203\026)Tj /Span<>> BDC ( )Tj EMC (45 \f\031\021\022\017 \023\024\f\035\036\024\023\036)Tj 0 Tw (-)Tj 0.177 Tw T* (\030\026\006\017\024\027\027\024\020\024 \023\036\030\017\024\007\026 \023\ \024)Tj /Span<>> BDC ( )Tj EMC (\031\030\024\r\027\033 \f\030\036\007\027\036\020\024 \007\026\r\035\036\ \027\017\016 )Tj 0.057 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\026\027\026\035\034\027\024\n \022\026\027\026\035\036 \r)Tj /Span<>> BDC ( )Tj EMC (\023\024\022\024\036, \b\026\030\026\022\021\036\030\017\031\033\013\036\ \020\024 \021\024\027\031\f )Tj 0.278 Tw T* (\r\027\031\021\030\036\027\027\036\020\024 \026\027\026\035\034\027\024\020\ \024 \f\235\017\027\022\021\036\030\026, \024\021\n\036\004\026\033\021\f\ \016 \f\024)Tj 0 Tw (-)Tj 0.322 Tw T* (\023\024\f\021\026\r\017\n\t\036 \030\036\031\035\034\021\026\021\t; \023\ \024)Tj /Span<>> BDC ( )Tj EMC (\023\024\022\026\026\021\036\035\016\n \007\026\r\035\036\027\017\016 )Tj 0.396 Tw T* (\023\030\017)Tj /Span<>> BDC ( )Tj EMC (\r\024\035\036\r\024\n \f\024\022\030\026\013\036\027\017\017 \023\024\035\ \031\004\036\027\027\t\036 \030\036\031\035\034\021\026\021\t )Tj 0.147 Tw T* (\021\026\022\032\036 \024\022\026\026\035\017\f\034 \f\024\023\024\f\021\ \026\r\017\n\t. \200\024\023\030\036\022\017 \f\031\013\036\f\021\r\031\033\ )Tj 0 Tw (-)Tj 0.002 Tw T* (\013\017\n \n\027\036\027\017\016\n \024)Tj /Span<>> BDC ( )Tj EMC (\023\024\r\030\036\032\007\036\027\017\017 \r\024\035\024\022\024\027 \003\ \202\215\025 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\023\030\024)Tj 0 Tw (-)Tj 0.344 Tw T* (\r\036\007\036\027\017\017 \007\017\035\026\021\026\006\017\024\027\027\024\ \005 \n\017\024\030\036\035\026\022\f\026\006\017\017, \r\035\036\022\031\ \013\036\005 )Tj 0.501 Tw 23.244 17.049 Td (\026)Tj /Span<>> BDC ( )Tj EMC (\f\024\002\024\005 \027\036\024\002\030\026\021\017\n\024\036 \027\026\030\ \031\001\036\027\017\036 \036\020\024 \235\031\027\022\006\017\017, )Tj 0.333 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\r\036\007\036\027\027\024\n \027\026\n\017 \017\f\f\035\036\ \007\024\r\026\027\017\017 \r\t\016\r\035\036\027\024 \r\t)Tj 0 Tw (-)Tj 0.307 Tw T* (\030\026\032\036\027\027\024\036 \f\021\026\021\017\f\021\017\004\036\f\022\ \017 \027\026\004\017\n\024\036 \023\024\r\t\001\036\027\017\036 \023\024\ )Tj 0 Tw (-)Tj 0.165 Tw T* (\022\026\026\021\036\035\036\005 \007\026\r\035\036\027\017\016 \r)Tj /Span<>> BDC ( )Tj EMC (\026\027\026\035\034\027\024\n \022\026\027\026\035\036 \r)Tj /Span<>> BDC ( )Tj EMC (\007\017\027\026\n\017\022\036 )Tj 0.403 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\024\f\027\024\r\027\024\005 \020\030\031\023\023\036, \007\036\n\024\027\ \f\021\030\017\030\031\033\013\036\036 \024\004\036\r\017\007\027\031\033\ )Tj 0.06 Tw T* (\021\036\027\007\036\027\006\017\033 \022)Tj /Span<>> BDC ( )Tj EMC (\027\024\030\n\026\035\017\026\006\017\017 \021\024\027\031\f\026 \n\t\001\ \036\004\027\t\b \f\021\030\031\022)Tj 0 Tw (-)Tj 0.051 Tw T* (\021\031\030 \003\202\215\025 \017)Tj /Span<>> BDC ( )Tj EMC (\024\002\030\026\021\017\n\024\f\021\034 \f\027\017\032\036\027\017\016 \ \021\024\027\031\f\026 \n\t\001\036\004\027\t\b )Tj 0.059 Tw T* (\f\021\030\031\022\021\031\030 \026\027\026\035\034\027\024\020\024 \032\ \024\n\026. \212\026\027\027\t\005 \235\026\022\021 \n\t \f\r\016\t\r\026\ )Tj 0 Tw (-)Tj -0.039 Tw T* [(\036\n )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC 1.862 0 Td [(\024\021\f\031\021\f\021\r\017\036\n )0.5(\235\026\022\021\017\004\036\f\022\024\020\024 )0.5(\023\024\r\030\036\032\007\036\027\017\016 )0.6(\r\024\035\024\022\024\027 )]TJ 0 Tw -1.862 -1.218 Td (\026\027\026\035\034\027\t\b \f\235\017\027\022\021\036\030\024\r.)Tj 0.016 Tc 0.241 Tw T* (\215\030\017 \024\006\036\027\022\036 \031\030\024\r\027\016 \002\024\035\ \036\r\024\020\024 \f\017\027\007\030\024\n\026 \f)Tj /Span<>> BDC ( )Tj EMC (\023\030\017\n\036)Tj 0 Tc 0 Tw (-)Tj 0.016 Tc 0.162 Tw T* [(\027\036\027\017\036\n )0.5(\001\022\026\035\t )0.6(\002\024\035\017 )0.5(\200\202\234, )0.5(\027\026\004\017\027\026\016 )0.5(\031\032\036 )0.6(\f\024 )0.5(\r\021\024\030\t\b)16.1( )]TJ 0.511 Tw T* [(\f\031\021\024\022 )0.5(\023\024\f\035\036\024\023\036\030\026\006\017\024\027\027\024\020\024 )0.5(\023\036\030\017\024\007\026, )0.5(\024\021\n\036\004\026\036\021\f\016)16( )]TJ 0.431 Tw T* [(\f\021\026\021\017\f\021\017\004\036\f\022\017 \027\026\004\017\n\024\036\ \f\027\017\032\036\027\017\036 \031\030\024\r\027\016 \002\024\035\017)16( )]TJ -0.03 Tw T* (\031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \020\030\031\023\023\t \025\037\212 \r\ )Tj /Span<>> BDC ( )Tj EMC (\f\030\026\r\027\036\027\017\017 \f)Tj /Span<>> BDC ( )Tj EMC [(\020\030\031\023\023\024\005 \207\215\221)16( )]TJ ET q 70.866 144.196 221.102 236.393 re W n q /GS0 gs 221.1023475 0 0 236.4666966 70.8661656 144.1222023 cm /Im0 Do Q Q BT 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0 Tc 0.038 Tw 9 0 0 9 70.8661 133.3959 Tm (\022\t\217\210\b\002\220 5.)Tj 0 0 0 1 k /GS1 gs /T1_3 1 Tf ( \207\032\031\030\021\031\031 \030\026\027\023\031\021\025\031 \027)Tj /Span<>> BDC ( )Tj EMC (\026\021\026\023\022\021\n\003 \013\026\021\026\023\031 \033\032\025)Tj /Span<>> BDC ( )Tj EMC (\027\n\023\031)Tj 0 Tw (-)Tj 0.022 Tw 0 -1.2 TD (\027\n\003 \t\n\013\032\026\211\031\021\025\025 \030\n)Tj /Span<>> BDC ( )Tj EMC (\n\033\031\032\026\203\025\025, \021\026)Tj /Span<>> BDC ( )Tj EMC (7 \025)Tj /Span<>> BDC ( )Tj EMC (45 \t\205\024\013\025 \033\n\t\023\031 \n\033\031\032\026)Tj 0 Tw (-)Tj T* (\203\025\025 \205)Tj /Span<>> BDC ( )Tj EMC (\033\026\203\025\031\021\024\n\027 \t\032\026\027\021\025\027\026\031\003\ \020\004 \202\032\205\033\033)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.02 Tc 0.122 Tw T* [(F)-16(igure 5.)]TJ 0 0 0 1 k /GS1 gs /T1_3 1 Tf [( The p)46(ressure in the anal canal dur)-37(ing v)13(oluntar)-43(y)20.1( )]TJ 0.089 Tw T* [(contraction before surg)12(er)-43(y)42(, on the 7th and 45th d)26(ays af)-46(ter)20.1( )]TJ -0.02 Tw T* [(surg)12(er)-43(y)]TJ ET q 303.307 144.196 221.102 235.209 re W n q /GS0 gs 221.1023475 0 0 235.2663564 303.3071165 144.1382758 cm /Im1 Do Q Q BT 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0 Tc 0.3 Tw 9 0 0 9 303.3071 133.3959 Tm [(\022\t\217\210\b\002\220 )0.5(6.)]TJ 0 0 0 1 k /GS1 gs /T1_3 1 Tf [( )0.5(\240\026\013\t\025\003\026\023\022\021\n\031 )0.5(\030\026\027\023\031\021\025\031 )0.5(\027)]TJ /Span<>> BDC ( )Tj EMC 17.264 0 Td [(\026\021\026\023\022\021\n\003 )0.5(\013\026\021\026\023\031 )]TJ 0.058 Tw -17.264 -1.2 Td (\033\032\025)Tj /Span<>> BDC ( )Tj EMC (\027\n\023\031\027\n\003 \t\n\013\032\026\211\031\021\025\025 \030\n)Tj /Span<>> BDC ( )Tj EMC (\n\033\031\032\026\203\025\025, \021\026)Tj /Span<>> BDC ( )Tj EMC (7 \025)Tj /Span<>> BDC ( )Tj EMC (45 \t\205\024\013\025 \033\n)Tj 0 Tw (-)Tj T* (\t\023\031 \n\033\031\032\026\203\025\025 \205)Tj /Span<>> BDC ( )Tj EMC (\033\026\203\025\031\021\024\n\027 \t\032\026\027\021\025\027\026\031\003\ \020\004 \202\032\205\033\033)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.039 Tw T* [(F)-16(igure 6)16(.)]TJ 0 0 0 1 k /GS1 gs /T1_3 1 Tf [( Maximal p)46(ressure in the anal canal dur)-36.9(ing v)13(oluntar)-42.9(y )]TJ 0.025 Tw T* [(contraction before surg)12(er)-43(y)42(, on the 7th and 45th d)26(ays af)-46(ter sur)]TJ 0 Tw 24.271 0 Td (-)Tj -0.012 Tc 0.012 Tw -24.271 -1.2 Td [(ge)-12(r)-55(y)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0 Tc 0.009 Tw -25.827 72.343 Td (\020\004\206\f\t\204\004 5.)Tj 0 0 0 1 k /GS1 gs /T1_3 1 Tf ( \224\026\t\024\n\024\026 \025)Tj /Span<>> BDC ( )Tj EMC (\t\024\032\205\013\024\205\032\026 \032\026\016\027\025\024\025\002 \033\ \n\t\023\031\n\033\031\032\026\203\025\n\021\021\020\004 \n\t\023\n\204\021\ \031\021\025\017, \016\026\f\025\013\t\025\032\n\027\026\021\021\020\004\ \027)Tj /Span<>> BDC ( )Tj EMC (\t\032\n\013\025 \030\n)Tj /Span<>> BDC ( )Tj EMC (45 \030\021\031\017 \033\n\t\023\031 )Tj 0 Tw T* (\n\033\031\032\026\203\025\025)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0 -1.2 TD [(T)48(able 5.)]TJ 0 0 0 1 k /GS1 gs /T1_3 1 Tf [( Incidence and structure of dev)13.3(elopment of postoperativ)13.2(e com)16.1(plications recorded up to 45 d)26(ays af)-46(ter surg)12(er)-43(y)]TJ ET 0 0 0 1 K 0.5 w /GS2 gs q 1 0 0 1 70.8661 704.381 cm 0 0 m 218.518 0 l S Q q 1 0 0 1 71.1161 673.9619 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 289.3839 704.381 cm 0 0 m 96.378 0 l S Q q 1 0 0 1 289.3839 673.9619 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 385.7618 704.381 cm 0 0 m 96.378 0 l S Q q 1 0 0 1 385.7618 673.9619 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 482.1398 704.381 cm 0 0 m 42.77 0 l S Q q 1 0 0 1 482.1398 673.9619 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 524.6594 673.9619 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 70.8661 673.7119 cm 0 0 m 218.518 0 l S Q q 1 0 0 1 71.1161 662.5005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 289.3839 673.7119 cm 0 0 m 96.378 0 l S Q q 1 0 0 1 289.3839 662.5005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 385.7618 673.7119 cm 0 0 m 96.378 0 l S Q q 1 0 0 1 385.7618 662.5005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 482.1398 673.7119 cm 0 0 m 42.77 0 l S Q q 1 0 0 1 482.1398 662.5005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 662.5005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 662.2505 cm 0 0 m 218.518 0 l S Q q 1 0 0 1 71.1161 651.0392 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 289.3839 662.2505 cm 0 0 m 96.378 0 l S Q q 1 0 0 1 289.3839 651.0392 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 385.7618 662.2505 cm 0 0 m 96.378 0 l S Q q 1 0 0 1 385.7618 651.0392 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 482.1398 662.2505 cm 0 0 m 42.77 0 l S Q q 1 0 0 1 482.1398 651.0392 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 651.0392 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 650.7892 cm 0 0 m 218.518 0 l S Q q 1 0 0 1 71.1161 639.578 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 289.3839 650.7892 cm 0 0 m 96.378 0 l S Q q 1 0 0 1 289.3839 639.578 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 385.7618 650.7892 cm 0 0 m 96.378 0 l S Q q 1 0 0 1 385.7618 639.578 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 482.1398 650.7892 cm 0 0 m 42.77 0 l S Q q 1 0 0 1 482.1398 639.578 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 639.578 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 639.328 cm 0 0 m 218.518 0 l S Q q 1 0 0 1 71.1161 628.1167 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 289.3839 639.328 cm 0 0 m 96.378 0 l S Q q 1 0 0 1 289.3839 628.1167 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 385.7618 639.328 cm 0 0 m 96.378 0 l S Q q 1 0 0 1 385.7618 628.1167 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 482.1398 639.328 cm 0 0 m 42.77 0 l S Q q 1 0 0 1 482.1398 628.1167 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 628.1167 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 627.8667 cm 0 0 m 218.518 0 l S Q q 1 0 0 1 71.1161 616.6554 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 289.3839 627.8667 cm 0 0 m 96.378 0 l S Q q 1 0 0 1 289.3839 616.6554 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 385.7618 627.8667 cm 0 0 m 96.378 0 l S Q q 1 0 0 1 385.7618 616.6554 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 482.1398 627.8667 cm 0 0 m 42.77 0 l S Q q 1 0 0 1 482.1398 616.6554 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 616.6554 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 616.4054 cm 0 0 m 218.518 0 l S Q q 1 0 0 1 71.1161 605.1941 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 289.3839 616.4054 cm 0 0 m 96.378 0 l S Q q 1 0 0 1 289.3839 605.1941 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 385.7618 616.4054 cm 0 0 m 96.378 0 l S Q q 1 0 0 1 385.7618 605.1941 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 482.1398 616.4054 cm 0 0 m 42.77 0 l S Q q 1 0 0 1 482.1398 605.1941 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 605.1941 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 604.9441 cm 0 0 m 218.518 0 l S Q q 1 0 0 1 71.1161 593.7328 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 289.3839 604.9441 cm 0 0 m 96.378 0 l S Q q 1 0 0 1 289.3839 593.7328 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 385.7618 604.9441 cm 0 0 m 96.378 0 l S Q q 1 0 0 1 385.7618 593.7328 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 482.1398 604.9441 cm 0 0 m 42.77 0 l S Q q 1 0 0 1 482.1398 593.7328 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 593.7328 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 593.4828 cm 0 0 m 218.518 0 l S Q q 1 0 0 1 289.3839 593.4828 cm 0 0 m 96.378 0 l S Q q 1 0 0 1 385.7618 593.4828 cm 0 0 m 96.378 0 l S Q q 1 0 0 1 482.1398 593.4828 cm 0 0 m 42.77 0 l S Q BT /GS1 gs /T1_2 1 Tf 8 0 0 8 141.8464 686.1465 Tm (\221\004\006\004\220\003\r\006 \002\217\f\002\202\b\r\b\t\005)Tj 20.091 1.2 Td (\200\004\204\t\r\b\003\013 \002\217\b\002\b\002\005 )Tj 1.308 -1.2 Td (\n\006\210\212\212\013 \(\021\037\031\))Tj 1.679 -1.2 Td (N)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (48)Tj 8.303 2.4 Td (\200\004\204\t\r\b\003\013 \220\002\b\003\006\002\f\001\b\002\005 )Tj 2.111 -1.2 Td (\n\006\210\212\212\013 \(\225\200\255\))Tj 1.633 -1.2 Td (N)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (46)Tj /T1_4 1 Tf 9.81 1.2 Td (\n)Tj /T1_1 1 Tf -53.422 -2.633 Td (\206\036\n\026\021\024\n\026 \023\030\024\n\036\032\027\024\f\021\017)Tj 31.244 0 Td (1)Tj /Span<>> BDC ( )Tj EMC (\(2,1%\))Tj 11.547 0 Td (10)Tj /Span<>> BDC ( )Tj EMC (\(21,7%\))Tj 9.797 0 Td (0,014)Tj -52.589 -1.433 Td (\025\030\024\r\024\021\036\004\036\027\017\036)Tj 32.703 0 Td (0)Tj 12.047 0 Td (0)Tj 8.653 0 Td (\226)Tj -53.403 -1.433 Td (\003\026\007\036\030\032\022\026 \n\024\004\036\017\f\023\031\f\022\026\027\ \017\016)Tj 31.244 0 Td (3)Tj /Span<>> BDC ( )Tj EMC (\(6,3%\))Tj 12.047 0 Td (2)Tj /Span<>> BDC ( )Tj EMC (\(4,4%\))Tj 9.547 0 Td (0,75)Tj -52.839 -1.433 Td (\212\035\017\021\036\035\034\027\024 \027\036\026\032\017\r\026\033\013\ \026\016 \030\026\027\026)Tj 30.994 0 Td (7)Tj /Span<>> BDC ( )Tj EMC (\(14,6%\))Tj 13.756 0 Td (0)Tj 8.089 0 Td (0,02)Tj -52.839 -1.433 Td (\025\035\017\027\017\004\036\f\022\017\036 \023\030\024\016\r\035\036\027\ \017\016 \203\202\221 \027\026)Tj /Span<>> BDC ( )Tj EMC (45 \f\031\021\022\017 \023\024\f\035\036 \024\023\036\030\026\006\017\017\ )Tj 30.744 0 Td (17)Tj /Span<>> BDC ( )Tj EMC (\(35,4%\))Tj 12.047 0 Td (14)Tj /Span<>> BDC ( )Tj EMC (\(30,4%\))Tj 10.047 0 Td (0,84)Tj -52.839 -1.433 Td (\230\030\024\n\002\024 \027\026\030\031\032\027\t\b \020\036\n\024\030\030\ \024\017\007\026\035\034\027\t\b \031\035\024\r)Tj 32.703 0 Td (0)Tj 10.589 0 Td (2)Tj /Span<>> BDC ( )Tj EMC (\(4,4%\))Tj 9.547 0 Td (0,14)Tj -52.839 -1.433 Td (\200\f\036\020\024)Tj 30.744 0 Td (30)Tj /Span<>> BDC ( )Tj EMC (\(62,5%\))Tj 12.047 0 Td (31)Tj /Span<>> BDC ( )Tj EMC (\(67,4%\))Tj 10.297 0 Td (0,2)Tj 1 0.68 0 0.12 k /GS0 gs /T1_5 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\033\030\031\030\213\b)-20.9(\035\231\213\233\t \021\032)50(\b)42(\032\231\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj -51.938 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 23, \023\0221)69(, 202)69(4)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 23, \023\0221)69(, 202)69(4)]TJ /T1_6 1 Tf 25 0 0 25 28.2152 56.0378 Tm (48)Tj ET endstream endobj 2130 0 obj <>stream Adobed     '$''''$25552;;;;;;;;;;   ####''',,,   ####''',,,   ####''',,,""   i!1Q"Aa#234qs$BRSTc %&'()CDbr*56789:EFGHIJUVWXYZdefghijtuvwxyzq !1A"2QaqB#Rr$34b %&'()*56789:CDEFGHIJSTUVWXYZcdefghijstuvwxyz?*\u=9#nc9,6w('DAeVW20af+ 9Z%sPq\C{X i -c2L.|S)Sxe{CuLRtɑh{gV(pDD*p4`Y*HŤU=ɅDZ#Bj6ΣVE'm`v+Vm n%YBY[_;9GK tHZ>Krך]uҢ,'=FLթ^$D\O&akS)pR]SkkfX`sMډ\=֟mq/ݼH1i%nBCGeIc}C d@=EjhѮ#*ΡUs  GrJ֕J}i_T).+Xı݊m*ZW)Jz5}R_ĸvKئҡz5}R_䧣ZW)JAKj+Xı݊m*zP)J oJ`\d% %õUq 74A Ԩ^i_T)֕J}{ڪ;,wbJ֕J}i_T).cv)^i_T)֕J}{ڪ;,wbJ֕J}i_T).cv)^i_T)֕J}{ڪ;,wbJ֕J}i_T).cv)^i_T)֕J}{ڪ;,wbJޒ-rd/ޯFSTWm'ZIq5QcT/FSkJ>H=pUEkؖ;MBkJ>OFSؗTV݉cT/FSoJ>H=pUEkؖ;M*zW)Jz5R_FpUEkؖ;MBkK>OFS{ڪ;,wbJ֕J}i_T*`%õUwbX6 ѭ+%=ҾORb\;UQZv%SiPNܠ'֯FSؗTWA!{' ,wbJ֕J}i_T).cv)^i_T)֕J}{ڪ;,wbJ֕J}i_T).cv)ڦy)uE <*N:F4=!0'{W4q/8$R3@|L:Wn((VYwL:%W(-4:v#>wE,h*Hnܠ soT=`wNAж 1N<xڮQTSVi5 p82% ڽ t,$2GWgW465CZHlJQYcDDڅzRUDɕr}qRiOEzuI6$cZ}BUSZjQ_Om# @#@2 7S rPU.E\RзpQmz/J$Ӫ@Hĕ^<;\ކAqs:FopC`Xx$41B@D|NLdFDfƫEQ}$ɓGkYBkYNڽ›WW*TDE{~m^_㺼62{Y*$NQ"--P["mN} lpݫ*-m/eyo;AՃ (r2(̋CCӶ4/ ZZ'ܤ,F 0 ACUtj6pJ"""ڽ›WW(j m^_""/ͫ){~҈6pJ"""ڽ›WW(j m^_"".SCp%\Hatڽ¿iDSE{6pQڽ¿iDDD_WSj ~m^M> ~m^Sj ~m^M+DDE{6pQ-aHuBIOl]vpQ*ڽ¿iDDD_WSj ~m^M+DDE_"֡ |oS?IM;TɾQYʨquͼIOjR FoRFOo@:=G_[+iny$hH{ i8TEH٤Ym72+)9鞕Pk @#P5RT?:uhd3;\!۵q#aAa%;<A(}+Up}G`9>5^[ kmkG,&IV;OyjThTgۏkS6PkVgY#Pt>p~וSyJǜT"/Wi4DDEo}ž!| ivME"- q)әT:k<ʕAo}\b7 ֔"PF鎃k!?Fnd2HW,*GAt+:-)\YVLp"KH3ehcIA$q'*M+i)UDEi4{zy{6DDD^^vMWi4DDEi4{zy{6DDD^^vMWi4DDEi4{zy{6DDD^^vMWi4DDEi4{zy{6DDD^^vMWi4DDE _ko!QW=V۵|x0jʪQɾW[[kd=ݣs.HkH]>h$9L722:^8'Vu Zv~'YH9`åH?6cܺPH TWJʩ xTeGpI[sK\m$8[ nDn=,L27Р,8/}B]yi=Iu*l5*uXs41΃ \L2IS1Zf9݉V(""R""%0)JB""%B?.Y1uA?.Y1Axa_@z_@z})JPPu˶_n?N:/֬λ}zMگگڪDD)DDDJsWi}r$KXASâ8!lf"sr+ 4/:⨊- ro0'oVI!lHP>'؍V'Sk\CguwT{I'=E')P)JQ)JQ)JQTWV#=TH wPL""FA۸MݍU+1&sk 0,d3g'tɌ}ij2YV'hYzxF9qo@{$/Xʏn9\G);8T*""R""%)J"""R""%)J"""R""%)J"""R""%)J"""'oSj?IMTɾUQYʨ1sZ,WMh"`WomK#oi U*Ā>tJB?eFBZ'u=2izyVB坕KOJ=efW87ԥG7_J$8p `8QㆨC61*4 \d32+D{aʹ<"ZA S}gtm @ҔV\Q)J4@uI $z"")8'' *5Σcfp]tɯۍF;yN#W`wQkFVm,c qCj>[E=c "hz4~]|cU۸Pu\T_@z_@z})JPPu˶_n?N:/֬λ}zt>h~~Q)JQa=>ow-'اƩ:cT`z`z""%)J"""R""%)J"""R""%)J"""Uf$/oo C;td)8:ܛ* T.$HEkheˮMDLi1.6vKmpH1ISc8GE*@@#I]!ZHuDA"4ܠI$dIܨD)DDDJRDDD)DDDJRDDD)DDDJRDDD)DDDJRDDD)DDDP$MmB 7㩵Wjaw7r;ܛ9Udzl Zs)hvg'{5ۅ#/׳1cT|$sh&htd ߻v<@`3]xvI,兤$h>FskzA//~PჩPt5A$w+Z>)]VJIeַ8m;ry={8m7Xػ8DZƺچ5[D0TΗ Nޔ$DJ(e v ʹ8*7 ˝el̩?=T"kkդjUX;Kz'$r) 1DL,OX:ΖQryuDCoy`mvsqwwVK$g HK^9.㙡^F C en%o3y.Lz^HEijKe֞>Y#ڗٌu";yx#m)6=$x/QkT=ڿ4gxg;EGnCne]z՘vT-_uzǁkGKR/txIiZ kYN?~nRB"/;Z~ e{cZ]qj܇|CMcW~T"/;1+(1+CW=i-+t>?5L?Dҽ?5MĩX''w?z""/;1+(1)~ J"""~ nRT""/;1+(1*60\t>T]QKu(Mjp}H[m%cSwDDEw?zy?7y^DDD^wyMcWQcSwDDEw?zy?7y^DDD^wyMcWQcW1QXN].T*'oSj"v5aw7rrnЭ\:?3d'MGNڑQmpsķ9/y$~kb% l@ T-&{$`alEbA'$ :Q_ .y_AU便4&5pb`U45(pt-kv_!k[SL1\" 7Y)1u7t{uR1)P"R""%~(蟗z:蟗zv<]=e ]=e>J(DEPtkZzFkUHde @۷/}gxZm2BI7<ճuzefct8 N*2dwvDS=k;\~K'jwQVҢUI*<|N#4>p9OAZN NBRmO8aYҔ˪DJ=k"""jPbShu>%Kĩ>)>%)J(DDJRDDD)DDDJRDDD)DDDJRDDDqMUS=ɿ4RG""䢽׈m%W(DDJRDDD)DDDJRDDD)DDDJRDDD)DDDJ*P (sl:ўӥEï)U/0C%`c33ڴ 'MZFh"%Lei=<^Ιj 2"Q)99(@7㩵 O$k] UQYʪèroTjomvG*1bI@z of<10 F F+wi`k8A5GJJv.ɷ .H8,LPǬu )E.QUԋ^X]lِp3  &knm洂"tЅ[Y(paY 4l.64yIs JZRd] -mјUuJRYaDD)DDDJU-%t0vQ, 3cnژ\f>sAoo ߵ1!{N%m~ѿUmؗ<1$lOdm]gӫRL1ꄹ0N 'CPtO˽}ojo2zQ]{"hzvu^rkYZui vR*QB",z凷7KYjX{sD=?&{^WsGL%ox+x[ ~O/ڸg;~ޏ\p>pB)*R/EB"%~W+Kn#>;3g^.t ,dz`k^&kq.xj4pi |HDR2RobjY;N%3$\>ű][mNg@ݻ98 }t;V+{CA_PPwP +zRgUDD)DDDJRDDEN5]hI>Ƅ/R kL@#!i b//Ġ zPk-^eh#AvyC7FBʮ*H3_5 d$T!k@OV'. 3rXI5օHW) 5-Z22Ii-&c\*K3@h%)J"""T]O&Ԫܛ*)nwQ^~""%)J"""R""%)J"""R""%)J"""R""/ʪ:xDBDV/8[TWڅKbDW@p=QVB&Nq Z_j&UNNJD)DDDP$mB7㩵Wjaw7r;ܛ9UN}<&5)k6ͮ1R8gMӡ1,Q4`a i\mjWTM9;~KުϽ]t{m|o TnE?$qTauJ&mt\nsEc!q$ѵQ,/\fG;gSg PUJ6O tsyDo>&))L-bҔV\Q)JSTDDY ѮLZ%Д=׮@uM5%Ӣ[aͳѧ(9uZZTJ?gIwR1YT8 'ȂvB'qO}:e {Kn.m8$"ioධgw&$LgT- <˻GgwMVnDdw^;ۉ>{Z;0UR})VWJx08%jKnnijN&7@7K0/'9""kyJ>?'fRIX*+A7 26ۂ,8m>pB)*-6-zxkPm׸IXG*juϸIXhO E^O=g{+?R7*F5(u+ث~PoڍTvU Q>O4O3[V܏U#شڵ/UM^DDD^v-6zyڽڽTe9sdxH“8qntPp}M^ ;hQgh%I5ң~*6-6-zyصSU>ܛ*Q?`OMJ[43\GԬ N}3hϦD]jmR .-@ &$M9vu6S m:3&:-8Z-ME9PG׶QJƈզůT""/;j~*}A}b?D?j DDS66~""ik(Zi-%,I$?!'ePMmQڣw]DYoikUXuMqY,yPWz&ђ5eGo ܲ1cp'885È%lZ$rK+^ԝJZI2>VKdٷg~ Nʹ_=^IQYIֹ:$ 5$)<=GTPU籡ee[ޜf-a"m~`juW rWjF)J+g19#88hRu  j94#UDE^Jaun2b0:y]f=i_@L9͖f#'7hq)ն'83'Q ʀLn:`@u!r5[b &YV`cZ'޾75hǂDcz}U.#3~SMןAٛK}}Otnw""e8_^̟"ⲚFiY$iTt3c9l+YǤ,{; -`yb@wM~TSk^ I"gy ej8S*M+xyBG1Tr9`'O\㺾&eL$7=|ͭ'dU  Nd8G{^\3"Hs! ӆT :GhRUR{>?w^}foz${>H{:/o*2=RNe* >~|{Dczc ew") D(² O(ub(ܾl᭎ʶ7 B̌˪n7`^ާmy}:n{Kni9!<7Qdؠj½yyJJ#ynwQqy)ϠWzT[{sOtnߔuGfҖ->S"".>?7P׆YP66lz%Y+gXh5fX{;<9:vv"]ןAٛy)Ԫ{6nw""#3|#3|ڔIizqyJ5ٲ2;کڗ.=ɿۏG3H6寋<~J#1+~-=ҋO;H>ϠWϠMw-=Z}ާDD\7^}foi#3|ޔIizpyJn%w->}Otnw;sB(02w88ٴ}ӄ`reʩ=HjԙXpu2~ۏń9 0eH81=rH 22X}b׭ןAٛԮvM۝{DEuGfw^}fok3K}}OtnwןAٛz@9v?<UsOt%7^}foҖ%۝{DE[N4(> .6zo R_P\u6Rè}ɾUQYʨ.qFj%LLK 4bg|7,\U ncsѤrڬAKhV;i,K*9j苵'䚠'EUUZ*ZWIΩXnt'iy]R*{ǶiCaw(>`mLJK h2 l)_ôyFj4D_(P2ugW{lFpnb;~^a"E;.S"f#G۩+eF2 Ӱt tֽ51}C%BUnHʡ'+OkHias`s{'JıϦC C8 -c\^6h'^;^qbrz^gC+rj):Fp/kCE69rpNT;1PO˽}oj$:}R5l(FMׂ`E̗ToVLU$wxax]=e5sFďTU='Н~SSTTDE\>yZO{e{k/_g:^""V>o8'w=/,o׀JWh:S1?o. J[cz*B*B ].LY\W̵(0O}gTugI_1o'`ډG^g]f@f. +6$Oj GO{[[D/fG}[ `ӝGG沷6F-ۃO ,IR7̀d|""04Z|PTFL"G`%a@RO(zeQ KTobo eqR֭ װnnGhm9Q*W4} =7yz~xjxj"""7αI~jQrPxu:<_ Y}bǬFBV#ne -quQ` @!qҭ L M$Knz{#3LBԩ7Xd9F ȜvtTն|6x4(%Ke13Lr$|V885/L{{rZG8U$g6hR3ʮڧQ\WMID@50-)$Fz2 vx6Ҩ$dvIr=f5\$@H.0DǩeuXM,Y46ڲ.vխ "JhcLt @| ,-B"XF7i53]\˜--i3 mŲrp'a-8jM)QT̒%ϸ`HD$sI0L`@h Q̩@!\jV ,{y꫊6n93SʋUsl1$MmZl^ApN̤ jw1}~Z)H#"zb ^[/wݞEvq7cNZˮJ]}% ZH#KĩtOZETDPemV ʒX欪F:&U]D;\+k]QaxHNշ8Hе ui&E6 Wh=A-U]ki3A%[9a! IU ıIϸV5"SUWen W5 7FnoGp]|es 8ZVi:9%֒3!wMjsТ{86!q15vqioYX>Ԩ03 .`[y}ܯR@ݴz%:ioMJvkpdҹk7wMgsh+Y܉v,vם"u H8GLln=eC84,::8piz 8CZp)3eRZԋokCL $m0f+q5i<=dmjmhmlo8V*DD_,# P O\W(B?.I1uA?.I1PuE.._J(DE#Q X"a2o }VEYs\63zo_GB@:_n?n|ZEakNɝ;Vz%:/$DDXS''E+a6:n * wگ\(UyA7'Z .RT")YWdDETOD3~HVSӮ@Di5X5!@#kezG<}ɾR5(u(GRA\y \popj5H'M_LTr@ϓCf1>#]U[Ώ(' 'Z5m"R]T&2}t>$HGibŹi#x1"*V-Xg(a="CQAYw6#C/Yyxexk]ZHr zՅPpwS;ý>g"(6rܦ?G}S!򎢫ӴddfXD[u=QPƟ{L&N l"9fCk|cG=h *7Ume71o9ۜyjo^.,m600XT R9*2m~A{[4xv֢TynE DVsm1 "X & 2+va@Wbݧ-2v0' #yx2̈!vAiUQu~Rers"ęs 5&K).,Ѱqw]61s[Tte`K֘gzS\9ФtʛT7 a7q (mu|iT7)dV*TI<"c6p-XL c Yڏq)[TDJW~Q+kТ""޽Xz2:x]|Vښ뻟`IfxC-m%J)[׎ ?/`}:PMmUڠXuM:&U@qUGg]i21W9߇o qVGBP.. ]b0"nr^%d*.SԊ܃T_= > $sjSpgUŧEǏpEMF\L@.NZj>1j8tn0`d@JǸ }4- {R1u-x:ts#XB2#Jgi.{Y@ē5F;;f\%:Zg\4EE$h O$gP (8*8>.4GF#4|rU0^ֲMtÌIqUMC=%4U /-t܋+GCx&>f%Z$ɌB)JfjwMSAZ'޾75](:"kYBkYO)R*wKoKۦ6eȆMS\ Ξ (JC_Ko8Wð{UU:qLJehnjQ*ڡ =H2VZ iim!sJRmx1D^]+ ""(:Thm?}1`E_RT]'؇Ʃ$J#IIf&9g,{nYČ"۽]r;>zqo-2 R:IN$-\g&U73\nMv'f@4W@4X_6i$&U:N[ns5{lny.0'5UܦNgg/xN_M:u'xaKD |GԮF<\95| eEꔝY1oCgIPVm,iqn;Tnd׳M)kE !:tU6J5iq~`>{jnaԩ4 a \xӧAэ#Eξ/MD,Ǔk 64<2oe8QyhxU 2< :[+ k*,ug k#6A""s酡;a `s\Zkbtd 5x&1R{}jXEV/.U pm $jV ypˮ wPXx_f Jx픍ԩ`aT;ȨMs=()֯#'}-[$""*%+({2L^)DNT5sOG TExxSNJs`=ԑ˷ Vڸ^/_ĸ#c ^EW$95ΒN3 U#ZJѨx b| =3qXԭ!KAV|0ʑz3[%,<­89l4\þ*yr7 Y@Kƞ=eo`|~ui>nGҧ\Xm$ +'?ZY;(&&C\nG+ T"jc[F% 7Zr'ږ?<PAADOũb74rhv_K@`""/ \3-'$_W(;d ev@~jBE "*Ƭ#)vB"A-Գx\cbbf8sR8r J8m#Vi=1B+5d}N ;nU;ZgyY2^fś99ށ8<@Lg1>@ɓp7I@RD FJ$A>wy+~K?薾u4Z噟wly㐚ˮ'4um}tob8wxATA쏮+JOo1N*BZ[D$\vaEwyD|V:$J""bn Qw\UZOo4H,ôP;E_?څTxez=>_y CwS=%̉$9teBිߛUBP* 5M3Xw>/kq~]־EikU.X`*>%J)^""'oSj?9MTɾUQYʨ6êF"Tdyz96Ic%a+o*AT[N :0g ٝȮ$Q$(".dA3>`k1(eZþ4.htwVCPC[n$SptYT c.ڎkI/})Su:.4OKO3$Cp 8Nq7WU$ҠzbH!{}3J [,BEc8bk[>%qN|N"19 Fy}zp|\F{c4Cr=]#ImVxsjZH!}jI@%\85'32)JɨWYQgNib1I:^Hi5eh tQsg,z<~-W,1֯.b7_O0F"+ ':Mon02>lT\1:G #\Kڎj58hmax0 8@S"5n\[Ѱ4dy{s$A,BϚ$j[ehbHiǷW0H\Un TyD#§`x LdOdz#UV~G]6v;Õ2* 6 Bȡsa ]\Ni)r嘫:zvui$QǺ@#\xPө5H^4,ō$S ;Hok4ApF;U_):A'5wlV$T}7*4FۢcEʯR.%X8:=_vʄMM_}7/}uz""&R(si(qק j>q9RW@tN|r=⹫ɾPq̷VvL ,* `8V4XLh&bns"W w͇n;s]P6H;FD$w"*QǸnQeOO'}H G`@FT>n6VI)EEƽU~im-1l?#j D&Ʈh4W`F"kYBkYw ?OJ|"0;=%SীY%> J@KG`J| ?R)Hh""IOe*E)-DDQ)W-]#P~W[l8ӁU3von2$;{W{ܮHlr":n\vo] A kS Uj[j(ެ~WFC9-m2D GDӾDH%r ?OJ|"[-DDY) 9$U& HzmLZn.cEחޯ yMvߪ$Lvݪ TAVv5cϐug iWDmW`3 Qi x۸\/2GYQY{Y%> xS^bUC=J|";=$DE?OJ|"ؖ""(g*,#. =_X_ [5DD])S,HRbG`DDQ)S,H v%""(g*ik(V%aVUaT$cujmixE3 v ?OC쾒wڈ""(}%> xWĴvIVx<01r&m%:|ucPMmTLvTVG{}g*q6-%eFѣ9 1k O47+$MwA%ʕU'98l=ynNhvݵ^hݻwMR)$dk˶T,eV xLdD_=_ +kj)\)4$6\0f L>,{MFp<!'\m7P3@Wh-~g3NPRd,,-͟idwµ)P""R""%*P^孭$hP=Gp+r{In(k\/)=IR)* "pMM.L0U^ ukUn Rlq5@sZI'uuPtO˽}oj4i,g)"SQQ4O˽}ojt=F kY u})*TDD)DDDJRDDD)DDD\/m"|pqЏ(#(yJ1&|& rʑn1:QDǖ89Zp:7IAA'}Vv1HAp+)E*j>Gըn}G9w8>TDJRDDD)DDDJRDDD7ϱI~juA}KV߲B6kjJDJRDDEGߗt_޳#߭7~]¢k^7};[y+7)(_+w?"OG ]L|K=Egj=zʪ{)J׊JR(ČQ q U;^..eh[ zuMZ4<F#qBM:5ƙqb褗eBJu8ln'Wۥȉ3{!U;uE'Vh_4$A;ʔ.! MŦ7.$gkc#$WoGP]:p2>TVYI1JRDDD:GBTW#CA>|Q__UDDJRDDEO$k)?/`}:Uv7VG{}g*ɾPkjޒ*FRVc;T3]Ms$Fn*Yoa2:Ia0ian߶pQcى^gn߻h;ToTr_SsSTIV.1ć2"pc_B)RSe2RCs\@8kxt4yl.Ƕg]]Ċ#ptq&:ƪޔB̈CJQOZӑu+,nqW-9v8kԃSӒPH|sd5Odj8&@SQov09Pmcr?kZpK*8E4fp6^Z.5PPz %#\#ظR<\htf0V*Zr>/ƽ h鲓@%$l-z4jDU,sc_58^# mgJLC*E{ZZR s[$wJRYcDD)DDDP5}3Oqp; #OOsm> A |5AWT'*9@`n&S#k w$BG篫7t U$ŧ863pktLsf& .ڏFFQaphql:3ñ8z}Ks5V Lዜ)5 F 1,ЕZ~]|cW0H4^oxg;Fj6q̴1r^\̸F˿9RRr<.Hq Tmdh83=֕ijU~ҿ7y7y~ҿ7y7y~ҿ7y7y~ҿ7y7y~ҿ7y7y~ҿ7y7y~ҿ7y7y~ҿ7y7y~gXh53w+á|2}zAB) {TWcMcURW11""/ڋroH5So.:Zo訥DE"?[_GUFޖWcEihihihihihihihcMcDDD_cMcDDDPdMmVG7^HnIFV'=jʪQɾW@iHDGf;4qE%Hߙ{{:!3Edڰ! 1 ̓pCuelr<$\qvԎ< ,T0A! rV=X/y787U+=+_[3\O(U骵hM6˫]sNeˀEȼW8uOSk^y{ZKmgcq!LHV*TDJRDDEKeI qiG-ռr'1(%}JcBj\WAe)sCc ⢗^j2ZYpp\B?.Y1uA?.Y1U:"kYBkYO)RB"%)J"""R""%)J"""R""%)J"""R""%)J"""R""/jՖd2@HG⫫-Ʋ,{f=g!fZ33'd:8qrxz"Ƣ=RxDZ*bX%Iz;TBsZcVv1!.a\`2@ 7NtFiXYy5*<C\E8u'M8| 7as㨚5sWclL!oJRYeDD)DDDJRDD_D&Ʃ DfƫEQ}R}(R})*QB"%)J"""R""%)J"""R""%)J"""R""%)J"""R""/Uaֿ6;ϖR""R""%)J"""T]O&Ԫ])nwQ^~""%)J"""R""%)J"""R""%)J"""R""%)J"""R""%)J"""'oSj?IMTɾUQYʨ=綅SE+.1RxJ%Hn&a$~f,Ѯ"Dyl*lX|1祼({Y%|j@\8pZyAjSD0EZҔ,Ȉ_""%)J""":'޾75N:'޾75](:"kYBkYO)R)JQ)JQ)JQ)JQ)JQ)JQTͧ^i0 E䪐=*ƙ{tngXb8[w~frB֤$FtN6L칭 ``'ڍh{t MܡYdPY vlAG1'ц!#1e VRIԮ/iak9wq[]#X)0u)PJR(JR(JR(JR(?9MR~_P&\u6Po:&UVG{}g*qp,IHڠj_ \&# B!܈[l,KMΰOM#5JᢇNP28D#,!zg&ΡX/IXkr-Ԋζq n2HY/O纥zEI/TLI9ȡ獥ckɨƚ=GR{u0wǗj6^\gq}Bd8g[RVYQ)JQ]l[hg1Hg#W2RdWf #t vM|;THDZx~>crp/vth*x'Ka@nsm{{6NGhVBhz1YXSGa=_uǁU..JRB"%)J"""R""%)J"""R""%)J"""R""%)J"""R""%)J"""R""%)J"""R""%)J"""R""%)J"""R""%)J"""R""%)J"""R""%)J"""R""(~_P&\u6K}Cqڡ*èroUaw7rryk1$nHӳ5dž_^XQ#$v +n9|Yƶ u9XT6YV15煢{LƏ0bܨ\B$fΫJRJ.R ̢\} 7[4[X8wQ}ZRPo~Vװ"&M%sf4퓀R>sZEƋHcZOVt*JRMuarZcF)2zb;(\_ۈcTc\яekJԌ㲅TvRqez~K84ѥJ)<7=!ilK] Ŋn\GRmQA挖GӢxl-jQm m#0'4aܡc l3Z~νLzsFďUѐ"31W4Pk= %7k= %L$wr{9;]vgg䩔H{w=ڪ(y{>JgYd*m)rGz'!ӓUEde :qBvD \2HeuԵ(4r8v=tF J4JQIlõX{H{wG&ۀzj=qėƴjOû}-p 9G4GWu'Mu'S)I*c|NNzCݪYd)Yd*e)%#rv9;]vgg䩔nNzCݧ'k!QCݬ[|2|ݬ[|2|2ޭH{w=ڪ({oOoORR;չ;]vUEvmSvmTRJGz'k!ӓސjYd)g䩕KGz'k!ӓސjn#&@S'P=Yd*>.%4@4H  iͼw TW 2bTbuWoGJn{>JJIH*ܝNNzCݪYd)Yd*e)%#[ސiH{TPk= %7k= %L$wrv9;]vgg䩔H{w=ڪ({oOoOW.)[ސiH{TPk= %7k= %L.r$;i%#[ސiH{TP%MqEktXPdd`v]u'Ql]F$hsh *02;eὃKm:~\dQWAæ3y=v7x30:i`1k8\* s%ȘYd)Yd*eD,Vr lhHPI1ީH{w=ڪuǖQh6scDĹ-cA&%~n{>Jn{>JaHhk{X*U$w\NNzCݮW [h$Gk^8N$. ggm>JRJGz'k!ӓސjAo.9!D[̧j})Q 0e :A\-Y,.C,Vlʌ0 k57r;V8I$LC-vnn5_ l tMINv0T3.`7b\ӱrH=_?uPW{("&45L9mwԢ)VHTTƽ{@45Lagi ^5ޯʷM=Jl4􆜒Jͷmu ']U)JȈJR(JR(JR(_& ,uFxm.K͵KVR2z_ oVH.ü,z"6[s+_Xՠ5L581u!Cq$ Ѡ5(!8=Ψse0H %)J+""%)J"""R""%)J"""R""%)J"""R""*b3yscL2V)؊;ZB2OjBNY52DHYBDD)DDDJRDDD)DDDJRDDD* mOeS(3?+rs״խ)ވ>ejC6:1Wڄ%uDXBShf-JV-hwa'3[M%7=i9j.׼Lqy:>$)ye ] pgbpIͤʢ[ъf,"Pf$JԮ ӵ5 쭱xVb HܶZUqSRDѩv[k64Z< æ0)ERIB atU) *mw:4o4dxEc^ [Sh2[U= u( KhUE_&`ES8 ( R>(q`vp͆L`H+o |74Ҧ(Ҭ Fv^E6HR*B+݌Ak4[B)8:]w/"B1-MB)s[X ni.F8q|U[x * oI=k`VT.g2FҵlZxn2#xL%bH_H-$M\Fy$© j@vK׌FMvO Pt5o-R#ܠ,o'9%js0[Ic j:pʕ.[B_m:wIgC7uϊYpWjk"M$ۆ8Rn.^B/yFp83QSCuJ/mYoEIËqazʌVk> }mpZVf{au #QU~\n...`tVw`imIlo>.Bzz-DT=ΡJB%=4ʬK" B\I;M$5l]uڂs{w^,#X[̹u_=~ /-DMM#/.-Ҡ ʎx(ZLe#!"^ƸdE4¸ĻVRwE5m6Rk1xc/AҤԬs IKT*g\HnnQIHBX&vS~@^:/jzR¹*0ՁG.sG@M]=Pw|CRim*dsdӢ6-uWwG!ɵK p;{aysG&3#"1vಌt}q^TŰX^cn䕭#ԓVkK.Ȗ3%NT@0gT\Ue-]kAsZ qx?,z?jz5Jx[< }(s=zIm -Wn+趵No{ȨM24&mbs SDSp.4o7\i3B"8B\Eg&n-ͮuy13*IF!KL9湥a ʢ}j=-P976D;CHbĔ*"/(JR(JR()J|)JQ)JQ)JQ)JQeau/.n[W!p;2;t{+IQsl-WEUwS9@]&y>jcki/COv{)W3/t" ͧZ h2k qK+n,>w+Iؿ^'iDqx0yXjYV@^H"yCVh@ }Ҙ m4;^ _qe U+8 -Fl,~/i hZ*tg1 jT3&t9Z=Np3Tm?NNA{btzZ꺎m:4ҤdkoVZG ć"Y*e>Փ:`.5u]ECQq hhpfNxxvUm"+SsP-r੿uzT@hinKYӱs}4][.L[l]0$w*/elT"ٹr^4y VEy`T{oVd,Vгg3=bHl'Sp{o ]Rz>-gKҼ: l`e`p%>"I-Xk>kMHu߾[$*@?Zv NJ: η%&4Ըj pثOP>) \h[ۓ1i#=W\7 pGF:Nm.5ԅN1CEֵ19.@h'qeFtS,$Mp"A\ Q|@}wn17ufJ t5I,!V\(@럣ڄ6 a:9XtuQHY{ w RN4y9"1I+t>Bn&\H`.5y*Lx\׹.m" 4$Bzigdp" @΃;k?w&PjtxX"e]{9Rz۝YyBBQIR{ZH$g/=,ppդeZWVs&;yN Sx5]R\_h r$»e.*U65R^9heF ӝVOaY$IrXwK*61׭d5MsUY.8] 11W󱷶"il3LLvVk<ְ h$ҹwj7GZ_ZZLW}Vmqi0QkIa13'h.y,0} }-lJJA0F͊fIaԷ}$5w6mv|>wU-Φ U\l=(>>Mļ@f v}2CH! p`3h7skFyo'+)5-Z!c' QhIӿד*tVs(cG{.s\IIlQPUT]U|A7V*8> 5cKlCB0 jN8IC,hSpf:'9DlF_>\ 79)77R}יM*#7HWljWjw}46[]o.̪;w"嶟x2Ue̋#0E_|l.}z`IPK8#IBJO/1 ^p{5: ˈ $E\OeZ|V V͢(#տAt] FIw WP]Oէa9iwXI-6pm‰>Rg;}M&ε*=ːv欤Z:v!%]ʅzҀb ^fF ﮌwܴ# ;OozԊd$  f|đϺ_uZ$qs$IwiOzKzS/ A|.Rpj}.oٞ!K^.nZ qROSC8V-gJsk%`ȑ+caeP]KqhB( XٵmjYKhEkX*эQs2}W[e ߄.Dn'I$ ϧ~Uj<$]d=u:f`ώT8$ҤWw821&Z5j|:\I Ǩ d--kj sv4)nXg,>)uզY͖E/S"{+/7jh2[OM: ݬB|hVC{3]5mKW:Nm`6{#,2]=zR LA9`C[T^nuf61ܩK;-5.ńűgI-/!QDzWLUҒUjSm)4`Ap8>O:8WE)S{Zڍp)wt-Z& dz>~FIchlAϼUq<+ibL4R,QCF R{%ikKww2I 8 mӐ -/]1O_mGH;3ؠ=q'vdS,c/}:uz'quZڬmF_JsIk/@ppu]BW\EZthm&U)W6qx֦]Hf'5/mZܝh]He>5+h/N+=`!؄rLwiz tU`}-9%2j,8x/wN"iHڎ (1N{Áz R)W?nuJLiSwEW#9Topf֩D5\zWt-TʄS$fMVY۲̍,o_z%'**.'ѮLnBhB́3ּ\s>dš晖 Rɓ6G@;G_-Ig |EG8f[L̎9G|<]zm..-eW\bLd+e*Pxv_R y-s <h [Xg9x3D(sZ\oe5C4t\CZjI<1z ޕ$ݜ6եhQ%vU:?$*u(܈hՌp=N+Z.9R"Kq!$n$IbD1b&6 ay.hjV^*% _|_SkTu/oJ>stream Adobed     '$''''$25552;;;;;;;;;;   ####''',,,   ####''',,,   ####''',,,""   s!"1AQa#5BRTr23Sbqcs $ %&'()*46789:CDEFGHIJUVWXYZdefghijtuvwxyz}!1A"Qa2BqR#3br$4 %&'()*56789:CDEFGHIJSTUVWXYZcdefghijstuvwxyz?tQEy`(7wP[ vyrNns4os%VlaIE&0SnOP** QV*4M@#BT')Ιiy1s4a&-ܾJ["C׷l)kp2X'RtJK[8&yj:mYi  lRyddGXǁ{3jsPeܭ \%1gt\5# ,xgլVQo.K\LRh|5n2Wuhhxs a7R[A"R*mFR89l v;zUjIcfGh+ Y%Q3;>P`m.W8VUW 'd&m ֹIknaB$S5-t5嶗Z2v/ci5 q/%kM(^+f{JҖРw@ʽtzU면T/n}jJN#t{]~c=NZROB)=*]Q"ke2xu(S6ߧRҒz)=*WPTͺxu)iI= p Ko^EBS6ߧQm׿O$("7].zm Oۯ~iGٷ^>ҖРw@ʽtzU면T/?n}*f{JZROB)=*WPTͺxu)iI= p Ko^EBS6ߧQm׿O$("7].zm].n;Nܺc8ҏ?n}-)'Azp Sh^*f{J+h`0;GJ4 ST$n#w2Z$w_Phv0EWgmR ť5Xip“jpjSkRjHbJdlTQEaePDDQEDDDQ("""Zzi}mjmBԚvqOMyG(EQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQ Sg|MSjVؾ& Ԭ #ѿ!TdfETr3_ @qm+[c)8aH&qHƈ7v<^nc L8WLmP9Guu v8Uf9H*F.HԦ닜\m-:jU(-:""("""F"=Y`ۜP$}3ȋeN}j(!q vOd1uЀIVeBuC 29iﵷɩ5⟁ޚ8!I<(((((((((((((((((((((((j5g=jPO5MdoXYҿZ#Iy( #=ZjcKy &\1sN8 Q%(M] 1QxwK}>F٪`K.suٰ96sְ鐹cESķhHc)!%wW;(&SeZڌ5(mSt^)֩u(4R8[^GϮUlaX(’֢")?jb4~`4zPhPNRɣNԧN G&LIiMg{o7 äg]9G5io-dPsT(<XtńuL!' ׏irY&A6|svOBҷk㪒)&_I햲&Zi844^k8=_BZKjC]# \u3JЫSZpdA L㸚uڇq2gPZZGQXnagHprkd̺i tdrjm mj8aTvVOM/Mg{UmJ(sԸsIpIə^Nky&:w;bu:Z+uZ/{̗IYqOMMo[VTTW",r޷-~*ʊ"""-~*2޷⬨"",r޷-~*ʊ"""'U۵ɉTR@>K:f[r Mӂ@r# hI ' ;w 80s奚4@ Qz7GT2ʓŚʳӵx&q 0 %0yuE/o#Ҡnӟ)Z>l%{,HS HX͟TsΤ@: V!gpț/$D:]V*R48n0g`S:׀-Kh7A@XO64PXMm-~*2޷⬨DXoF[UDDE[TeoYQDDDXoF[UDDE[TeoYQDDDXoF[UDDE[TeoYQDDDXoF[UDDE[TeoYQDDDXoF[UDDE[TeoYQDDDXoF[UDDE[TeoYQDDDXoF[UDDE[TeoYQDDDXoF[UDDE[TeoYQDDDJYg(\Gܸ;iB>j{665%02r4 G, ӿťO\xc{o0'4HM?_ LL֛2!Ջdi\!dĭ8f!a\'|T0xd$ŒаQi@7S,;_\ﱬsU}TyNo Mxl.sZ@&U2>8"7T`未݋[TicjT><7T{SVdz<+ÇJ]=D0ֵ9qQE%DDQEDDDQEDDDT+OM/MMV_{[VȽS;^k?5>("DDQEDDDQEDDDQEDDDV,dYQDDDK7]EP2MʓH"""(""("""("""("""("""("""("""("""("""("""("""("""("""("""("""("""("""|՟/mB>j{6adoX@:|V>P3Y\,m(6aG*ݬǧJТ7 ^,g@|ԣ$e.d2{X' .m+Ve>ugM7b39jݎQ$ ֽĸ@m|k VLe6Q׺2a6rLՖ()-z"" {%-&hIi%9EsDEc}&U&CXSyi ЌaOETXJSN {@ÃP̀H䜝Zzk}mkVss=ݿK5̖.1. 󭶞^X>jCz3Swp5 |ԙɲZ& 5PqOMO+++EQEQEQEQ_L=?Tk絇jB|C(((((((((((̥dPH,0V'f)$X03=>XyJ{YB'0Oc{KL"Ad,8W[Ra0EV*N dA!>2&dAes[jmaƻZh"xR1s {sVY"7aFʔ8שalU(`s[N Ddd-j()"""("""("""(""(Yb-Sg|MSj.AYFվ2[ X1$E$ugP^KyWk;Uo!y1`BX(i汦R[ ,ʯ`×/%{goE)k6j"9q Y+es%uOakk3M9  J=.P ?-k f 8ɜʧq=P԰<:ZeͭMFAQNXgR@.vݸ+ KP+;ˤnM>wvr29(ZiԞ"M 2 t8*wۆ)zgy1HS8cb8v8#ms9d d 9sfJ{Wך1<0eڶkAEB KaL7ʸTO ȶ a%PI[N:(iOC4#,mrN;h uL@yeOvqL&ODmj`ִ@rOIܬ=4yY9^K?57j(ؾJʊDEQ|DDEQ|DDEQ|DDEQ|DDEWW|D?eSveyaQI;FVTQEc|m_%eEc|l_%eEc|l_%eEc|l_%eEc|l_%eEc|l_%eEc|l_%eEc|l_%eEc|l_%eEc|l_%eEbQ|M.-JMp[ _ls̊uPuEnJ5D8ao:5,9˳9I5b+*+I""b(ؾJʊ"""j)u\q)a>gΕ6[!DF"0w.p|K\ gd^̤J,-͜8jx\`&H;5d"Km`rDy :vm-,` ß>ډh} ԭ3&qVT I@yb[kE̟tODAX ^ƈd{-$.a$;L OdZ3L4O5Ap7A.$NUQ|DJ[H ՕEql7/%2ZYb\Rǹ{A =GNA‚Zզ$֙ uy@#=VnS+8k 1<esʛ,PHv ByT}kzu<" d]pE;PN^!X0`qU 8F>= )F׹ N)5]{1kڮL-֥N&QHT4i1$4|`&("("""("""*&+OM/MId^)5⟁ޚETy"("""("""("""("""k絇jPm}2MS}E'oEQEQEQEQEQEQEQEQEQEQEQEQXοQXοާO{((z͐>t5cF- (*EhLyJ""(,""(Yb-Sg|MSj.AYFC5cb$2(ȅf%#᫋[tJ$@';Gڲj1i-+萂9*M·NWWϺAJ#l7uj:{)?hXQֽ5e79.{i25l* G2J}'.$ynL Vkܼ2L+N)SS3B+4^鞃dQ^E`- fȈڍOy 7ēHڼ0,^ `ebr vfVrT^&0hԸ@ܒVx:Ew=7U-`s4}6-ip$ rk\vK‹w;UI'T7gf(\ME #I|ت͌cqq".۪Π܌Vv[yoJʖ _n@ Flbgp8 N2ܒCC}FpUJIܳ&h22LdtnjѢW D{Z e2IQw]²ķI1Ė-6vv%ͫ"eY{KkoQxmnf`$ 1 OPt _O1BDaI\ (\88 b"{gcȭ5Ӽ%eEcQQaB>j{6jVX ?5g L.AYl:fmDLzTDEBhdT,pz;H'IlA W3X:[+q }cP4Hvn5xFU_ |;$u.u 'o.XP\qD5A[TkpjiOK{'1c+5϶̃{/lA;94mށ~;i:Ԯ#[n=.iV{s}-#܂06T^ 67X<ܩeױCfq:"RT ` nu(p.4F5n2Dž-QNP{LpK Oea,1L9dCڮ)"%Me-!$amnx;D,c*6cc[@41 )˳1[( A8L&gu@5D ˪/5*P=4y56Zzi}mjMCdL/G(y4!B}5&="GHy ""%DwCssvRYJ̎ 3Z7NT%$Ƨ@<`h((WuA]>R~!DEQEDDQEDDDQEDDDQEDDDQEDDDQEDDDQEDDDQEDDDQEDDDQEDDDQEDDDTGc:ےTGc:z>xҰtDDS""("""*=5"~`#A3oM{c+}hLy((Vؾ& T?_TڋjVFa:Z4|+<덱hZ^0HX:A8ps'52KlQrHG'cK[綐 Eq(ι~j ﺖ \׆mcxHsPlZõZBbbA0v>ڦ[Fr <eI/yɌe{s HTZ[6<D6 8MxnF[PRnV5n廲5Jv?*Z{\3$P^yi kp]A[DѲ4id` MU㥓ۨm85 &uE&WDSmi:8S")Ym9x̸lE,[pO $jCh";QEQE@>j{6j5g=jQr J7, Z qmҝP[e *$DR]M"D$$qġX@X{ ݐM%y"9W^Kxͼ v#9'NѴr 39VsZt=էs\Z 4nJ(7e^P$sZ=VZׁ޺m> ӲRu'SQ80XrV+׻KYKv>ByR-?Saⶆ=ÑuQ+GU}Z7kyF)k)mـA#P?ćҭP'TRg&YRApLA uV8mFZH`pR;!QXŦ @lYpuٝ[ka}gkWvؒDOxZ}:u䪒Ŝff9f'Z=4}Z}% ֡ 6 8Q}7r4p2^FZ0XqOMM+ŠyW {A""%v6^[MtmʞMߪ)ըz7N?wI,uQDX5aFI1tTVQBeK2bgS|u추.ϰ_loQd '^zQV~Ū!zmkoصQ=KǪaQRnz]7 p_:½(+(¼ܾZ]O{FQ4{OH+1vp0@} D^M̪^1ނnh#3h)1.q! Ѽyl'\C5R4c̐ GӔW+ \A!pr: ptEo+Mcȭt DD^nnXDDJ[<*w. ߌS*|՟/mE5*lc׸ 4g#m2|J #ӿwI,Q%(sQ4M/fhBѣ5v.;*gzk5-qĄ30AIr+] Ohi#c4n< ԟv¹D׮sYӫP[F; 0:UqZ˶+XTxo%Lu6IU&j ]-I+Mn Z 7itl׋tNWd@vL(g3FZqsssr8v9 /,- *"͒z `nJQ4FƝL%Z+.aMƵ%£"zUiR}jIֵIq0W^ ks##dqڊqΊzJ""("""Zzi}mjmBԚvqOMyG((ty$b7DCTqs*ƹ;zKrFC *˙V<=*9s$Jڐ-@p26uu,\D^@ƄjΣZ,aU ɁMNf&W` 67 A I5+H߱jT-o1UІ]^zí#_YX7 8* gn*>>VRnzZMid˛U4^|C&g4MI1tU]EQEQ :_K X!>zoP5S`z}k,]0NV/NPYe<7geUuG;)m<纘A ),#P63Y(bLN@B#8ۮ2Mē*"(""*v q #\kdD(YfKcʪ00351XaY ʊ$`8qQh;O5M#'Rw:Ęl"(""("""+4DDDY{bֲNDI!tdQ,~\Ina0&/1MQx0II"'cgQQ%Φ 78e:Ukp@du1 lgİqVk:cކzv7T{ Ī 3X\b01|}e8J\7%4I:Dk^%gո1GJa{^ZA eaeFhrjZ\+<y)UXo$b:1>/gnOS5]g֡]a]+g4tt1y7Rڛ #mv1[|*=u8m!W0\jnzX_8..5# =k2dZ/QpǤ|MqEUQDET?_Tڅ|՟/mE5+#ͻX<)*D{A6$X:[/zXq2oWj n!(4iyCI*F,03I8Vx<=bͭky%BL9 ..m5Sii;J>Z9:-eOes12U>5`kj={VRcc[Q/lM*xVpLsKZ@JɪL|HcTT92x`9UC6$ |( ܡX'}ʻWʞNj9hDvѼ-5pKNą>QXBZ:t羣ֵI0I'e5:Ԫrkyk49#WH  v'鲟k=ͯRu3" Z~F8Bn5Dq,d'E-{&kAsZ5I6@A},1Ax[m=ac8z5 '܈;dHRp^=öVQeK1RYa}rn' #׽+?X8=PZ^t' BѤ߾ld>hxf:E&Bf<*qOMK5-R5ZK\ȓ$HQqOMO򤲼"RGώޒ.\y) ]o= ][\h% >,ηy=t*I"':)֏E/Y`_EFʂC<ѿs(>jqbHg#έM}!Aȯ~Spsp==q (jH$]vY$xvWM?",^ꌏ*\3: !uc) > g5P ""\T-ܲOR#ru\Ko<.^}C0ix-8x|@o}(*)-y`'jcU]H 6PvL$<=aIgXBVAȌS+Fe<U(jӜud֐ƸMD^+-|r!CnZ=Ψeƛ`/RN`z׵ &<}Py[QEQEY_{JPuxt>YXE4vWY%ɶq"@=vP yQDDE,:Kc\tLhzݕG"ѮBO g'X-@OEq.Q$/V;K K(*pDqi;MGSπg^7̟JixV1K=aB 0-"d1+=Xgf U{ >.&ʤF6qּ9$h`ZtO5LzW }'ލL,R(((fPJMNx0I?z~7ZzDE_Կڏ43~1]f/k7#}",=WQ0[Γjڱq tUx֏>]/ް#ioJuV?Vz_{{b쿲ITN(ۭ2"(Yb-SgMSj.AYF闶v&l9*bA Mۓ^ mU]3#6eV!恩iژ(bLecr64 ]3QLL 0Wn/Eja4c[%KA} ]KJhT9}7k:vCx~Jj՝}9ZahEfqd^`؅I\wAqMSK+`xYݴ:żWZmżIFߴ9uU/cC-\D.ȪL{{ea NNƗ ..pS;  {YEg#AmVikQDIp"pD%G)Tm/!w. I;LQ4wN#q({WzU`ۤ:DLGĮȩߴq9xʔ,o=+Ii3}g.h%*TcH8SklI8Bpc^eEݦIa$*3HFsϝcZUdeԘ* zYh ρbմwk?Jڬ{m* X-  U[c%DsqcAu/vČHZK[KkiBOs<)bsmwst.ĀlV!TgP=4y5!=!"#¬qoq}:lk-.eѰ&H j*mΫz?w ϻYW%戉(kNQ?2Kꇂ+}ozsŭ㽛(DDAYfMD_y;*?<<j}TGs|v,,|ͤYdSXI+z^ϵorH[E:,"\"-RAx|̇iS3Op6*pH" Pe]~Υ[w D2tl˰_moVQN5Z'J@:K-Q~ZߧjV"4IǪݙ |5GW=zaㆫXRnzEI;}Pm 0Pq3OK}gZ!'WVuK99A?Zc#3{tχy*(<7)71>/NW&G~q]^Y} N=?\R'CK=Gܢ")|ݣo7N`{ԃ[3XQ"5""[,I-ЕIJlQ s{R=CtV8n3!1eo_w5Sn;PAj^\s00HGSMZZL7xIul.9)&4TH$Ҟ^jfχm3'ڼ#h9 2c2TZ8jX\kTϴi )h2$Xu!ܑlFkL'nY8@cXbQZn<]cltFq/cEϡ槀u^>#F.dDid*FU<xX䑥eL3cgoOԧ{2FCD&n'I @$FVBҗs?Eҿ0c>2.Ԣ",vϻF9k*(>|ݬ"",vϻA_9k*=Yc_BFXv'ID$8*zUg9e@drB+Om&FAEcA'_U9j+b~{4YXYCy`uי1aoЫ*LxRۈ#<"QV4p ǃYXRs3Q^vsפ,Zeu qr~$J+*@́o,U׌ouV؝fŤ2x W\S/K; JxG8n Iв7/~x{Həo:##¼ *{_JԜLɷ#P[q"O|ݬѨ"U[YO1q<Ρj5g=jQr J xnnFAu #Ơmhv =Ý+xl#-<'ȦzSMGrJv ΓCq)XmJf7*s'bJ4wTB$Î&&XN$J$6U3J{mJ-Ez&76 #&U}5٫IazJ k Vp^6,0\"@~Um$-3[ P /dQ4rkCKitNkA\f b%07ѓU[Ю#=$hYBPI#axUfZ sVgjqMJ|9<9\ahDdQIM1Iy;Ӳ.*x*<8i]imjp ֮tQEaMiQE KkoSj&Ճ/GךqOMO+*HAtXI`#c+G/} VW2)>֗L@907yԡN͓$""*]Hg5n<@кrrPթz7MWxRZ]4hq 4zL!lJ,"򽢊@u:+r9簚T)]-b>,QaHczOֿvA *f[M8jGiݍ5<=\BŧH =+xE0:hFl.v$ ju{_B8ǡ9BzDoXDWVQ*G#M R m"ͦZJ N_DLogIaذ#s>5Y1"]6"[bm=a֤&CسLg5E[|EOY7F猭w}[ȉFc?QW?U.RpwYʋ+ëYpF5J[Ț6d19}zqYb *1s}jG\٘'c=R{Go noZ-Y|# \$`]}OE+C˩s]#2ԓm\tCēo%#ys]K޵WgCG ~ ˳.C7|h# QE|"""o?R,͈Wh5m0!:|StDEvIS)6ًAiI'(?4}j'c.$mTiT-"=7ӅqDE::W$}5k:XF`}"J"^T[痤yDq{d4\\I,G;i A> DDS ( }Z%g4j|?iF~yIc4z&8~Í\OI ".y7pMJbm2wHjgj #NJX6P @uq[ |}ӰlotGGJA'TDE%de70¯3GiW%yC y3]vOB#y vXJLƃόdcOaoOB'ݩ^֔+ws"M0X[(rj.c,$v$~[o:O{kGĺ oK 7YF =OD sc4U{Zx[ұtz0UęGϨ2>2gPO+.H(;_qEViTQ@>j{6j5g=jQr J7, ڴ4PR1+ո,#MRcb q {l&Nsϱ\D HB:Sz{M&ՂD\U=sO-dy&pX̃ʭ&}:xKCW[6)wפOІUd1 ȃǼs8axVʼM usUA 'zv[z+ѩ< *OQaFfG(peZn$״'vunqcE kS.=܁ 4I4G)"SdchzYI GrD-ZH8 ^5QFXʖCjĀDAHRHw_) vbo]#oUy'[hRFᶣmC@FNN+ uK.{x`ibU#Q:m;|,]8[ZK8n3h^[tl )ԯ[wQjUQl^Kko$78A8VAKkoQxpn-$oy4pv0&ǭEѱWH *z$>T.ZӯG׷QjLԫIy%eǭړ2aS2$݌ȃV?(G^k2:RҼlek=fLvt|t(DDQoK-ߚKt#!<|3O(GYssX3"am=pGQpDD[+Y"rQI=pGGO{塴 pDDPWCbH{Tjr@ʣQl#3O(GX6#A)=bHQFB-1ʐv)f'jsjr[op;uF;|R&l26 "%WFRjwH5H1|IqtVCG8ڕKm!sA L7E꧸pp#"L-5;{!B;$r'kBN&\Fb\ ҉G~*$6P3L'h+eDQ;pNV' k+IOHc p7$d`wޞ.|ʳ7#ؑ␦hTN$7 5xߜqxYUG=Ǡ4z(nYU&-ϹRR /uH1~!VmMRGs4^G8GwE$:l覎L>[cwi!xr50-9 pA`sXڇypwdOH&RKdMg@[HnU0MPWD8Ѐ֟0] E!2 -:K!g;;aA>%)^$ӑwG;@oJݨ#&\sFI$ZgF ~1p=`UծAA>$Z|<4K 5F Np-$UωⷀFֲ3NHZkk1j3Qs p|+H%A:Uk>y0s.my^M^$ mպԷ( Wa=WU295Hh A䈲9s%"54x+\s/dGI>gZ\2"-V7F_|șfkYR(8kt)knaTAElt|%kҗh=.DD\'fi;̀>:dا1psRҎ_Zk7O C?2YuWGt}>DElԿڏDzWTh(+]ٷ $wj~FުXY#+ uyXt:ttVGJ#yQ^0[ΓjnY2.P 5!ZNȑ.InQ.Rρ!b;~Zx_ұlUʑ7 Hb#^#vGqWe1ԙ؛}u'kXVA:?\=B\:TQD>j{6DYB)Qɹ|~ iXqFIaM<kd2rP@о=Zdtt`;IjÖ)iq'C5S-;ydnU3nER)7xn`7|_ዕÕVkY eQwhE D 罋MlT*]F -dHk,6* o1/Pw55m:7:Fe^AI!έAED\JL;1TN]VQi-;&yԀ ~~J<+u 0:""v@ޯ^xcV--:Im\ T ~~Jk絇jY NOkgAۨ,"VC}}?z%n:mfJ"vAޯG}?z%n-i;OW~_QH kzT4ѠQ7)=Fb4կ]гy-Tp$O|-}b<#19~Vh坁An3͏cI A?k$15A39/]<9hAĜuyip6yf.S9G`w=aVHS_1~J9 0z4V@-fad4+%rց$`nO̶3=}Z+V;e~fk =&ƛ&MɅuX]dMA-D'Үܥ "N js= ʸ%ipp$G9psxBJoK}g(1>jCUItA jcnR9K O'5,Q[Xa_6`2@I1;,\NH,"vAޯG}?z%nb"""vAޯ^K_WȈY:$^2ZL UIC\YmDErf)o,s]Jnx6 `O y.6~kkq(ICI F{լuG!iYTnnL;⺌v)=JR<tnL>h6AZ8Hp}"b5X:׶&#NcQvAޯ[ ݭDDDwYeXF;ps*L\L7}WUls6Sq ˈxU4) LpdU&1#yދ",Roe4x0I$@3L0ԟ.g Ddv(\Wl 66Sz/ʇ'YκW}?z%iUtDDQ),8OTjcPB7Y~b\! R_ѿ%Ķ[ bH.Ai K,Sﵕb"dd&bͮeq5bff+߀i]knJm[f,+$i'T]}NUʎ-c^N`4:ex~pܷ J(M֭5/ ibBpծ\9:2^ns{ 6H]N{RjoJjT {*=h$\(""+5t""Vm gp%C3Ţ[GH 3w"aϖnT`W9ǛdF;>0axǚ&Vc:s%O"Mn$\Uʆ9KΎN yTiB׭62NrfrI⟁ޚSwp- ϼZEN+6}]An- ϼZE,~R)n- ϼZE,~R)n- ϼZE,~R}]Fn~}#5i:$/̚X:Rz}}tDD)Ρtcd^5Rx[ۉMdvS=zlp=_Zs9=- ϼZEb*6}]Fn}}ũ4R)`n- ײ?ZEd4)K_舊-8<@@xՀ?^jT dR3֏)A0T\s@*.$1}tYXEicbK"b(TE`s>Y4OAw7_G>hn}Ԛ*6)Yu舉f]3YE@T(ʁhTfz-"m/MRcAZɈ${ OJ"2{a-yE&wm"N<>cފplng?Gcl Ru¿˟ڼmIK-`ey`K}V )׍cȤZ.ui#­vEkElR8ACiqO]B#S8\F~ajS{kze"50vT=Gc;z&vЕ"JwCu-I`_舊7Cus-I)K_舊?Cup-e-9#l7oͣTsu|z|(M7tIjmn}V?8>",~R 舊7Cusn~Ԋ)`_j̲ٙ%<2>[@熦u T?_TtDRnT( mOp8en'%܌23qYP˥I H܌A1GVoYhd!&+3.wN@\ɌuG1q։$7iSss [-ֺFTg'Lsrm0ڌsii q!*d2'6J棪8z\h4ŠL0()-:""jha67QKG8Ttbxeׇm'Uh69,$ z C FJQ L\m UQw6Zuk.+ [d[!O,I\Ly.u-\ۃXx(|cҺ WRu,ĢCBN FZ\;eP_knsDLA'u0q._F9;8s!Yk IWRk:'>Mcx\ ^Z %z7uW; 5*Q  nAH<ȣh}c OM/MU9駒Gi1'y+LI6`ph|K9-R-,Q{XqhpnĀds'w MO NeƈɁ'`Jq㠜SZ+I,$DYQXMGDDDYQXMGDDDYQXMGDDDYR]n+@àY `grJ &k3U k-E5κjQXMGEDYQXMGDDDYQXMGDDDYTc/L<,dkxmfnMy2R#QyJA^ki|Hv?S k~A ""ʊhRh?""(Γx?X&.q{v[dM{qU7(א]ju6 d DZU* x.pNLX( z ->_p\) Уڴp"_ AeIM}M6YenȪ2|PJԫ5l4 ׏(բ1# [| M4JHչak%P*0+͢IԨ舋*(?"""ʊhRh?4DDE)YvRmeyfAO44Ne8?4 B;ɝ]"Kmd!*;sT6#Q'm kp'C1Je;v1OY*{o4&"hN~eOMmz>-{@8($`;:s:?N2DVk4QqkAs潮&H` VYQXMGEDEG[FmMhQs;pV?8>"kocQ[&(*+IhRhj5g=jK5[X*筼]Ŀ4q)E5+#›Znp:AP@E' Hu`TPIAMSTxf01%sU`Ke`:U{3DD!g:6N@5KxW;i8 mk{i4NjZK\`ΪdJ"*VmB]QP0b sg]c^ F:~E)kkQ[ @lSՏ-l砈´E%DDQEDDDQEDDDT+OM/MMV_{[V^)5⟁ޚETy"("""("""("""("""("""("""("""("""~nVsf7\9slrI-u uC48DB$`<5m5›#mȸ~tJmg5$. oJu6Q-qpvy5UfON ߵR:OvwExPBF=0`|GEQE|x݆iC}'ޚT-(vIYvQEEQEQ์qʇq׆Ȓcj6ѹGrQ04 Ĭ"Ԗ @v'()4Z`N:DQEDDDT{u?jEGOSF-{c+}hLy/((j5g=jPO5MdoXYo[k{]MO3^·Xv6>>dd*qkow42A2ybR-d6qA b}?:e_gu[3ȋyg7a%ւAeXÀ* FQ;q{HNVZ*R{=-p ":*dQ!u72w_{ ÏٻyV ߎjo,Hpv85%0  iɩ |K:׷ڭm_f6 !Ay>JM"'uI2I2I:zT3MM**JJ:o:o:o:o:o:o:jʊ"""ǯhʊ"""ǯhʊ"""ǯhʊ"""ǯhʊ"""ǯhʊ"""ǯhʊ"""ǯhʊ"""ǯhʊ"""ǯhʊ"""ǯ棯k*(ᣯk*(ᣯk*(j!F!z1=2+3fEw^mݎ~^,(R#{\k- h5y#**˩tr("yVtm!>fr;W^I!i4k-74Z&:jʊ""U S;1LVؾ& ԩ}͸&F%aFlU\nH&-ἱZK~ı›eRqə+N(Lq1Bn% 2!Mޭ\#1,1 AbN>AQo}=~`79A]ڀGقI-ȈIcs+p̪]]QD  q , q-ڎ k9mĈ.i +׉ 2-U+1ky-`v:4QEEIPDDQEDDDQEDDDT+OM/MMV_{[VȽS;^k?5>("DDQEDDDQEDDDQEDDDQEDDDQEDDDQEDDDQEDDDQEDDDQEDDDQEDDDQEDDDQEDDDQEDDDQEDDDQEDDDQEDDDQEDDDQEDDDQEDDDQEDDDQEDDDQEDDET?_Tڅ|՟/mE5+#Ei~OHXEOAKOAS>:ҽZ 2c 3*lg=`=PDҰ6nlH<3KJ|?%:DҠ6QP|u%>i~OHXEOAKOAS>:GdQ$t"ͧTi~OZ_S(:VfRT*dQ/)I+i)i>E:/)xKJ|?%GJ,z Zz EA֗~J#am=-=Nˮq'V*;+u2XFP+9;(:VH1 @2 DƊ/)xKJ|?%GJ,z Zz EA֗~J#am=-=NKJ|?%:DҰ6KOAS>:GdQ$t"ͧTi~OZ_S(:VfRT*dQ/)I+i)i>E:/)xKJ|?%GJ,z Zz E- 2L2AQsd'xKJ|?%GJ)6` X:/)xKJ|?%GJ,z Zz EA֗~J#am=-=NKJ|?%:DҰ6KOA^j5g=jJ/uK 젷dm9e7djPoX^:h1B@мW@,MhJe3hs^sqeड़Ckb7EF<Gil4iL$,72I;D΋DV&XcKM=50,K0k% m qIbzW֏rzVUTDXOZ=6'eE';֏rGYQIDDEܣbzVTRzc=h(؞{DDXOZ=6'eE'֏pQ=h{Q 9og8HqbJ""z]j|=Ԫִ $[R( UB{tSкGp`UyqEcw-Mer,35Ȁ' =^ay"]A =!]5jR{Ks /'l!yNt!ZCh3,yZ.i;֏pW֏pW2IĐ!rTt RZE*`;B> }IІ]ml؞{VLI63ނzs!=ng+l}1|*K^^˿q`z7Fb`N iS=s54 KD:g* Myrn0Cf7݉G^O *AڟMwǻ!u\k +8{ȡx"(\c+]zeE:Bš\=M3H0YauK4շ-[tF4Pw ꦥ@`6 Yh4&2zdQ[LcrZ<XwRZ\X62Ia Qz '>2Σ7cǕ:\gGu\eFHʢ+m Yb]; ϸ+mQd)9pkI@LtQEy`(((((((O]\YhwwVW\du\q0c:?(p"cTc5S-'/H~ƾ4^ s& tqEAHDD]M/%\\p ܬW$vwT5y$Q-.6A2ܱH& %@2FGoeLyEtYhE"|Hk8"'mn^) 8яj#I^ e:u!6KCH.yΠ8NY4>7^ֱwKL4S& -;\.$xwI0%1FBpA }gl:զ7'e_a,V,.&ր &I0xqm:lI-!f5N-+%4Gt. emlyYfgyZn#&zemgnn #sbG'n0qj)4-xC܇P9u$t>Ĺz?Ck>es+ 7@HT[خ!՝DCXk:L& 0#3BZV7rU(džZA"@23Pu:u6s燙s#2%J~%[hQ&1B8J@3K,@NXh9< BԖXX%Էs ƨJ<]^/.'1܇1 tBKԼή}vSԩUa-ͨ kB~נ3V1pAnqTq\;Q齱Iy(>9`ԽNɶ<3)_<5fbZz$fGh^hT# Kc w"9YXY| We)$lH\v˝h/ XP̰ k1U'Ȁpܛsp$c^TVZMJ4D5jз&'9[\θE5ﶻW1# .ܐ<&]іH`Xmu>FRN=E55tK;&`"D%y5Dt֎ =-eݨ\\J2) [΄ uԽ˞Ws)Y}a]MK<Á*n&\$9h sw Po)9^MÆHv2YjWKQcZQho3 N3-eQn urYZQi${Eqd*MB([(=R˓ZC6ucM]Yy]5bmj=p΋7bkqMzdsʵMsbmiIWxn,>#IXmZ5-1F|NL:' mXYLmFz/n]ǻ5+T6VFh;$q~/.%ic ;@N5iQtDfNVdKmn*S})hqV sqDZl/ttO kV N"u&Tieʇ:%Ak8w<ݣUUMZcRn.K>54p#IVB uyqjR3V g4Wp6lt mW[ΒF_xQ -|IemǶwƽ5΢LnɸPo JWcir l$llx;`:ZeTn̋5P" -*R $67S9N3*o140 t.1T&9m;)*y6<:p.`^<;:4'cYnlt9p*;>Bay(""("""("""("""("""("""("""("" tQEy`(((((((o^Kaw lx`wq?qohs)t >zQ.uCq9q̷8j+U?i DNrq!&qZtAp9c?^f*CgYAQM%Ԭ.e+f3uUȩ.9bZ^ +1)y+n] tuS98I*c]@"`Դ#/7RZ88 '#g Mk}:n 8b\$x$i*Z en%U"4 .Zi dTPuR%4kR|MGTyc3hˠ_'C$G2p{}{Hy c ~х^ INm&g[d*] CEພEH%$i Bw*[:Nxy {8Va-0IѪS[]DT⩾-5ϸ8e{E-; F yrn`R;ߚs&^ȃ4 ܊㶳x#=3u{kט1ፖq5(;e'44bzr<)TSmpMIsvvUUHs+UqCL~&GfHn#202Og<Vɵ}>L g1eb%ݶEmig Jn)2#.1[5厝=H*y9<֦3q4*Tϴ4pۨT)279Ψ$ 8[nTU>"jUg7s m_s0͆73 i[kX[U5և>#&YVKu +a_-{h0q 4v[ 6KM"kJIikP G.մJIebU.![H6fJSm'Ӧ}we t"V+v;R*$1e6ưuRSe*M$՜q޾<^ pr>5`80hp֐H ՆcIc2̨p Ke"of$#rj iWw%ȈyDJ yXi4ɬ騻e0|iX[rq<%~ E7Rql2$t Flf18 {M ZT*ڍ%shpKӪJi%5 Zb䵲P+18ʨyj-P7\E 9)E揨[}caIiu(*K kNmmqu1YC3MnWZD&s3)O[Zkiq# $򂡘i3?FNwu)kj<0Ȏk8::}cUAv$@Kֵxd{H-O* *G}37g*09>m~5[Y. .^a/MX>AiRҧviGnޑDjvXTpK]k tXqh:HT6 T傷.J&p՝iF.& Zڬ?l."ɸˇ@QEaz*c("""("""("""("""("""("""("""("""("" tQEy`((((((( cU)*Sڬ2+AtcEz!p;Cf}kUVs]|-9^/Rqk)Upr",g+ejPI*!l}ƖQ2km/Fy A8hS[յNIc{gxS<2̷X3:t)08Zu11*TZ)3OKUv/m^6ƵSFsi6E"k']?Oj6ZUy*ԨJq4ʵ﹒v%]Kpߌ?s2GI v6M>u@Ǡ[p[n+Lec+7ރ#8=n,sd2Hȟ;Gd'XyWb111& E*Dp'ƗîYyo'do]S5 ؘԪ粣i㓵>q| z##ם,a7S{KIּ6'Smۣ7g`]iViń%ڀ,JB'>LP Wu#>Zk6qu'Gm#36EJ:UݹzN];JԴmnX$ &l'J.c! FyYYfugǯ_* $ LXΘm|&e '5Rm6c`` b;)oVu2]UpycEqX^ Mݧ1$(FڸU_;*k.LtXktC5 g{ksZD澵EA%PwvyPO=,OWlx_$n:Jˋnq.sɒI;+Sx":t!]ľTAw 1siHkñoGVZ|= Zǖp!"AsVW]C)#+ :DݜcpiKgks9YGp1TIOSòޥFI$HͻLWf42 LAMu[oӊR/u R/sA 2|.b|)i:Nt7vFhu1ث_hqg'm¯9[;/?dzkOwaUejw ZE5үZuK8ONiӈsBDbH]Đʺm^D0<Պe$f1w`$U3@{l+ISФ29hTRi:{S8%I'5x*q=ns 5*զ8WTGv^59w w%{HxOOӓQy-,v:O>H4D,#||j5X[nljpi`vT6asy8:fguEQXYDDEQDDDEQDDDEQDDDEQDDDEQDDDEQDDDEQDDD@tQEy`(((((((((PZt HɏT팱+mDSV[9Grl lن*(((((((((((((((((( endstream endobj 2174 0 obj <>stream endstream endobj 2173 0 obj <>stream endstream endobj 2126 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\037)31(\025\001\026\002\025\007\220\002\215\016\024\013\205 \227\220\002\n\215\007\ \205\002\001\013\205 \201\220\007\013\026)11(\013\227\220\205 \220\022\f\025\n)10(\025\r\013\205 )]TJ 0 -1 TD [(\221\025\201\n)10(\025\217\001\013\205 \006\225\220\001\n)-10(\026)11(\016\002\025\026)11(\025\024\220\205 \221\002\220\022\007\016\017\016\001\220\220 \207\002\025\ \001\220\017\016\006\n\220\207 )]TJ T* [(\013\001\013\007\216\001\020\207 \026\002\016\224\220\001 \r\022\006\025\ \017\016\026)11(\013\001\220\220 \006\022\202)10(\016\024\025\002\002\025\016\024 3\2344\022\006)-10(\026)11(\013\201\220\220)]TJ 32.735 2 Td [(\021ontr)20(olled cir)31(cular dilatation and later)21.1(al subcutaneous sphincter)20(otom)21(y )]TJ 4.673 -1 Td [(for chr)20.1(onic anal f)-20.9(issur)31(es associated with h)11(emorrh)11(oids III-IV)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0.497 Tw 10 0 0 10 42.5197 615.2279 Tm (\n\026\022\f\017\n\026\035\034\027\024\020\024 \007\026\r\035\036\027\017\ \016 \002\t\035\017 \007\024\f\021\024\r\036\030\027\024 \027\017\032\036\ )Tj 0 Tw 0 -1.218 TD (\()Tj /T1_2 1 Tf (\032)Tj /T1_1 1 Tf 0.126 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,02\). \203\026)Tj /Span<>> BDC ( )Tj EMC (45 \f\031\021\022\017 \r)Tj /Span<>> BDC ( )Tj EMC (\024\002\036\017\b \020\030\031\023\023\026\b \007\036\n\024\027\f\021\030\ \017)Tj 0 Tw (-)Tj 0.174 Tw T* (\030\031\036\021\f\016 \027\036\022\024\021\024\030\024\036 \023\024\r\t\ \001\036\027\017\036 \023\024\022\026\026\021\036\035\036\005 \r\027\031\ \021\030\017\026)Tj 0 Tw (-)Tj 0.05 Tw 0 -1.218 TD (\027\026\035\034\027\024\020\024 \007\026\r\035\036\027\017\016 \r)Tj /Span<>> BDC ( )Tj EMC (\f\030\026\r\027\036\027\017\017 \f)Tj /Span<>> BDC ( )Tj EMC (\023\024\022\026\026\021\036\035\016\n\017 \027\026)Tj /Span<>> BDC ( )Tj EMC (7 )Tj 0.147 Tw 0 -1.218 TD (\007\036\027\034 \023\024\f\035\036 \024\023\036\030\026\006\017\017 \002\ \036 \027\026\004\017\n\024\005 \030\026\027\017\006\t \n\036\032\007\ \031 )Tj 0 Tw 0 -1.218 TD (\020\030\031\023\023\026\n\017 \017\f\f\035\036\007\024\r\026\027\017\016\ \()Tj /T1_2 1 Tf (\032)Tj /T1_1 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,48; )Tj /T1_2 1 Tf (\032)Tj /T1_1 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,94\) \(\217\017\f.)Tj /Span<>> BDC ( )Tj EMC (5,6\).)Tj 0.279 Tw T* (\230\026\022\017\n \024\002\030\026\024\n, \023\024\035\031\004\036\027\ \027\t\036 \f\024\023\024\f\021\026\r\017\n\t\036 \030\036\031\035\034)Tj 0 Tw (-)Tj 0.391 Tw T* (\021\026\021\t \023\026\030\026\n\036\021\030\024\r \f\030\036\007\027\036\ \020\024 \017)Tj /Span<>> BDC ( )Tj EMC (\n\026\022\f\017\n\026\035\034\027\024\020\024 \r\027\031)Tj 0 Tw (-)Tj 0.409 Tw T* [(\021\030\017\026\027\026\035\034\027\024\020\024 )0.5(\007\026\r\035\036\027\017\016 \023\030\017)]TJ /Span<>> BDC ( )Tj EMC (\r\024\035\036\r\024\n \f\024\022\030\026\013\036\027\017\017 )Tj 0.282 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC (45)Tj /Span<>> BDC ( )Tj EMC (\f\031\021\022\017 \023\024\f\035\036 \024\023\036\030\026\006\017\017, \ \022\024\f\r\036\027\027\024 \023\024\r\024\035\016\033\021 )Tj 0.29 Tw T* (\023\030\036\007\023\024\035\024\032\017\021\034 \024)Tj /Span<>> BDC ( )Tj EMC [(\030\026\r\027\024\027\026\004\027\024\n )0.5(\r\035\017\016\027\017\017 \f\030\026\r\027\017\r\026)]TJ 0 Tw (-)Tj 0.099 Tw T* [(\036\n\t\b \027\026\n\017 )0.5(\n\036\021\024\007\017\022 \035\017\022\r\017\007\026\006\017\017 )0.5(\f\023\026\n\026 )0.5(\027\026)]TJ /Span<>> BDC ( )Tj EMC (\235\031\027\022\006\017\033 )Tj 0 Tw T* (\027\026\030\031\032\027\024\020\024 \026\027\026\035\034\027\024\020\024\ \f\235\017\027\022\021\036\030\026.)Tj /T1_3 1 Tf T* (\027\t\b\007\006\005 \205\003\201\002\b\003\205\b\n\005\t\215\003\007\007\ \255\206 \003\201\002\003\207\007\b\007\215\210)Tj /T1_1 1 Tf 0.316 Tw T* [(\215\030\017 )0.5(\024\006\036\027\022\036 )0.5(\024\002\013\036\005 )0.6(\004\026\f\021\024\021\t )0.5(\030\026\r\017\021\017\016 )0.6(\023\024\f\035\036\024\023\036\030\026)]TJ 0 Tw (-)Tj 0.086 Tw T* [(\006\017\024\027\027\t\b \024\f\035\024\032\027\036\027\017\005 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC (\021\036\004\036\027\017\036 45 \f\031\021\024\022 \023\024\f\035\036 \024\ \023\036)Tj 0 Tw (-)Tj 0.174 Tw T* (\030\026\006\017\017 \f\021\026\021\017\f\021\017\004\036\f\022\017 \027\ \026\004\017\n\t\b \030\026\035\017\004\017\005 \r)Tj /Span<>> BDC ( )Tj EMC (\210\206 \017)Tj /Span<>> BDC ( )Tj EMC (\025\206 )Tj 0.116 Tw T* (\027\036 \023\024\035\031\004\036\027\024 \()Tj /T1_2 1 Tf 0 Tw (\032)Tj /T1_1 1 Tf 0.116 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,2\) \(\230\026\002\035.)Tj /Span<>> BDC ( )Tj EMC (5\). \200\n\036\f\021\036 \f)Tj /Span<>> BDC ( )Tj EMC (\021\036\n, \020\036\n\026)Tj 0 Tw (-)Tj 0.435 Tw T* (\021\024\n\026 \023\030\024\n\036\032\027\024\f\021\017 \007\024\f\021\024\ \r\036\030\027\024 \004\026\013\036 \030\026\r\017\r\026\035\026\f\034 \ )Tj 0.01 Tw 23.244 21.92 Td (\031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \r)Tj /Span<>> BDC ( )Tj EMC (\025\206 \()Tj /T1_2 1 Tf 0 Tw (\032)Tj /T1_1 1 Tf 0.01 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,014\), \004\021\024, \r\036\030\024\016\021\027\024, \002\t\035\024 \f\ \r\016)Tj 0 Tw (-)Tj T* (\026\027\024 \027\036\023\024\f\030\036\007\f\021\r\036\027\027\024 \f)Tj /Span<>> BDC ( )Tj EMC (\021\036\b\027\017\022\024\005 \r\t\023\024\035\027\036\027\017\016 \207\ \215\221.)Tj 0.569 Tw T* (\212\035\017\021\036\035\034\027\024\036 \026\032\017\r\035\036\027\017\ \036 \023\024\f\035\036\024\023\036\030\026\006\017\024\027\027\t\b \030\ \026\027 )Tj 0.076 Tw 0 -1.218 TD (\024\021\n\036\004\026\035\024\f\034 \031)Tj /Span<>> BDC ( )Tj EMC (7 \023\026\006\017\036\027\021\024\r \021\024\035\034\022\024 \r)Tj /Span<>> BDC ( )Tj EMC (\210\206 \()Tj /T1_2 1 Tf 0 Tw (\032)Tj /T1_1 1 Tf 0.076 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,02\). \203\017 )Tj 0.06 Tw 0 -1.218 TD (\031)Tj /Span<>> BDC ( )Tj EMC [(\024\007\027\024\020\024 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC [(\220\021\017\b \023\026\006\017\036\027\021\024\r )0.5(\f\023\026\n\026 )0.5(\200\202\221 \r\t\016\r\035\036\027\024 )0.5(\027\036 )]TJ -0.049 Tw 0 -1.218 TD (\002\t\035\024, \027\026\023\030\024\021\017\r, \031)Tj /Span<>> BDC ( )Tj EMC (4/7 \007\026\027\027\t\b \023\026\006\017\036\027\021\024\r \027\026\002\ \035\033\007\026\035\024\f\034 )Tj 0.071 Tw T* (\f\027\017\032\036\027\017\036 \021\024\027\031\f\026 \r\027\031\021\030\ \036\027\027\036\020\024 \026\027\026\035\034\027\024\020\024 \f\235\017\ \027\022\021\036\030\026. )Tj 0.085 Tw T* (\203\026)Tj /Span<>> BDC ( )Tj EMC (\235\024\027\036 \022\024\030\030\036\022\006\017\017 \n\036\f\021\027\024\ \005 \021\036\030\026\023\017\017 \f)Tj /Span<>> BDC ( )Tj EMC (\027\026\027\026\004\036\027\017\036\n )Tj 0.163 Tw T* [(\023\030\036\023\026\030\026\021\024\r )0.5(\027\026)]TJ /Span<>> BDC ( )Tj EMC 6.518 0 Td [(\024\f\027\024\r\036 )0.5(\007\017\024\022\f\017\n\036\021\017\035\021\036\021\030\026\020\017\007\ \030\024\023\017\030\017)]TJ 0 Tw (-)Tj 0.087 Tw -6.518 -1.218 Td (\n\017\007\017\027\026 \017)Tj /Span<>> BDC ( )Tj EMC (\f\r\036\004\026\n\017 \027\026)Tj /Span<>> BDC ( )Tj EMC [(\024\f\027\024\r\036 \035\026\027\024\035\017\027\026 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC (\023\030\024\023\024\035\017\f\026, )Tj 0.305 Tw T* (\027\026\023\030\026\r\035\036\027\027\t\b \027\026)Tj /Span<>> BDC ( )Tj EMC (\f\021\017\n\031\035\016\006\017\033 \n\036\f\021\027\t\b \030\036\023\026\ \030\026\021\017\r)Tj 0 Tw (-)Tj 0.056 Tw T* (\027\t\b \023\030\024\006\036\f\f\024\r, \031)Tj /Span<>> BDC ( )Tj EMC (1/7 \030\026\027\026 \026\032\017\035\026 \027\026)Tj /Span<>> BDC ( )Tj EMC (65 \f\031\021\022\017 \023\024\f\035\036 )Tj 0 Tw T* (\024\023\036\030\026\006\017\017.)Tj 0.008 Tc 1.157 Tw T* [(\025\035\017\027\017\004\036\f\022\017\036 \023\030\024\016\r\035\036\027\ \017\016 \021\030\026\027\017\021\024\030\027\024\005 \203\202\221)8( )]TJ 0.013 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC 1.243 0 Td (45)Tj /Span<>> BDC ( )Tj EMC 1.269 0 Td [(\f\031\021\022\017 )0.5(\023\024\f\035\036 )0.5(\024\023\036\030\026\006\017\017 )0.5(\024\021\n\036\021\017\035\017 )0.6(17/48 \(35,4%\))8( )]TJ 0.279 Tw -2.513 -1.218 Td (\023\026\006\017\036\027\021\024\r \210\206 \017)Tj /Span<>> BDC ( )Tj EMC (14/46 \(30,4%\))Tj /Span<>> BDC ( )Tj EMC (\227 \025\206 \()Tj /T1_2 1 Tf 0 Tc 0 Tw (\032)Tj /T1_1 1 Tf 0.008 Tc 0.279 Tw /Span<>> BDC 18.171 0 Td ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC [(0,84\).)8( )]TJ 0.499 Tw -18.171 -1.218 Td (\221\030\036\007\027\016\016 \024\006\036\027\022\026 \023\024)Tj /Span<>> BDC ( )Tj EMC [(\001\022\026\035\036 W)22(e)-18(xner \f\024\f\021\026\r\017\035\026 1)8( )]TJ 0.2 Tw T* (\(1; 3\) \017 2 \(2; 3\) \002\026\035\035\024\r \r)Tj /Span<>> BDC ( )Tj EMC [(\f\030\026\r\027\017\r\026\036\n\t\b \020\030\031\023\023\026\b,)8( )]TJ -0.008 Tw T* (\f\024\024\021\r\036\021\f\021\r\036\027\027\024.)Tj ET q 42.52 133.37 221.102 238.864 re W n q /GS0 gs 221.1023475 0 0 238.8673588 42.5196833 133.3667809 cm /Im0 Do Q Q BT 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 0 Tc 0.14 Tw 9 0 0 9 42.5197 122.5701 Tm (\022\t\217\210\b\002\220 3.)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf ( \207\032\031\030\021\031\031 \030\026\027\023\031\021\025\031 \027)Tj /Span<>> BDC ( )Tj EMC (\026\021\026\023\022\021\n\003 \013\026\021\026\023\031 \027)Tj /Span<>> BDC ( )Tj EMC (\033\n\013\n\031 )Tj 0.046 Tw 0 -1.2 TD (\030\n)Tj /Span<>> BDC ( )Tj EMC (\n\033\031\032\026\203\025\025, \021\026)Tj /Span<>> BDC ( )Tj EMC (7 \025)Tj /Span<>> BDC ( )Tj EMC (45 \t\205\024\013\025 \033\n\t\023\031 \n\033\031\032\026\203\025\025 \205\ )Tj /Span<>> BDC ( )Tj EMC (\033\026\203\025\031\021\024\n\027 )Tj 0 Tw T* (\t\032\026\027\021\025\027\026\031\003\020\004 \202\032\205\033\033)Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 0.051 Tw T* [(F)-16(igure 3.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf [( Pressure in the anal canal at rest before surg)12(er)-43(y)42(, on )]TJ 0 Tw T* [(d)26(ays 7 and 45 af)-45.9(ter surg)12.1(er)-43(y)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 0.083 Tw 0 72.346 TD (\020\004\206\f\t\204\004 4.)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf ( \215\016\003\031\021\031\021\025\031 \024\n\021\205\t\026 \216\201\207 \ \n\024\021\n\t\025\024\031\023\022\021\n \032\031\f\031\032\031\021\t\021\ \020\004 \016\021\026\006\031\021\025\017 \021\026)Tj /Span<>> BDC ( )Tj EMC (7 \025)Tj /Span<>> BDC ( )Tj EMC (45 \t\205\024\013\025 \033\n\t\023\031 \n\033\031\032\026\203\025\025 \205\ )Tj /Span<>> BDC ( )Tj EMC (\033\026\203\025\031\021\024\n\027 )Tj 0 Tw 0 -1.2 TD (\202\032\205\033\033 \025\t\t\023\031\030\n\027\026\021\025\002)Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf T* [(T)48(able 4.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf [( Chang)12.1(es in the tone of the inter)-13.8(nal anal sphincter relativ)13.2(e to the reference v)16(alues on d)26(ays 7 and 45 af)-46(ter surg)12(er)-43(y)]TJ ET 0 0 0 1 K 0.5 w /GS2 gs q 1 0 0 1 42.5197 704.381 cm 0 0 m 102.297 0 l S Q q 1 0 0 1 42.7697 692.9118 cm 0 0 m 0 11.219 l S Q q 1 0 0 1 144.8169 704.381 cm 0 0 m 68.031 0 l S Q q 1 0 0 1 144.8169 693.1618 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 212.8484 704.381 cm 0 0 m 68.031 0 l S Q q 1 0 0 1 280.8799 704.381 cm 0 0 m 39.685 0 l S Q q 1 0 0 1 280.8799 693.1618 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 320.565 704.381 cm 0 0 m 68.031 0 l S Q q 1 0 0 1 320.565 693.1618 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 388.5965 704.381 cm 0 0 m 68.031 0 l S Q q 1 0 0 1 456.628 704.381 cm 0 0 m 39.935 0 l S Q q 1 0 0 1 456.628 693.1618 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 496.313 692.9118 cm 0 0 m 0 11.219 l S Q q 1 0 0 1 42.7697 672.0926 cm 0 0 m 0 20.819 l S Q q 1 0 0 1 144.5669 692.9118 cm 0 0 m 68.281 0 l S Q q 1 0 0 1 144.8169 672.0926 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 212.8484 692.9118 cm 0 0 m 68.281 0 l S Q q 1 0 0 1 212.8484 672.0926 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 280.8799 672.0926 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 320.315 692.9118 cm 0 0 m 68.281 0 l S Q q 1 0 0 1 320.565 672.0926 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 388.5965 692.9118 cm 0 0 m 68.281 0 l S Q q 1 0 0 1 388.5965 672.0926 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 456.628 672.0926 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 496.313 672.0926 cm 0 0 m 0 20.819 l S Q q 1 0 0 1 42.5197 671.8426 cm 0 0 m 102.297 0 l S Q q 1 0 0 1 42.7697 660.6313 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 144.8169 671.8426 cm 0 0 m 68.031 0 l S Q q 1 0 0 1 144.8169 660.6313 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 212.8484 671.8426 cm 0 0 m 68.031 0 l S Q q 1 0 0 1 212.8484 660.6313 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 280.8799 671.8426 cm 0 0 m 39.685 0 l S Q q 1 0 0 1 280.8799 660.6313 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 320.565 671.8426 cm 0 0 m 68.031 0 l S Q q 1 0 0 1 320.565 660.6313 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 388.5965 671.8426 cm 0 0 m 68.031 0 l S Q q 1 0 0 1 388.5965 660.6313 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 456.628 671.8426 cm 0 0 m 39.935 0 l S Q q 1 0 0 1 456.628 660.6313 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 660.6313 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 660.3813 cm 0 0 m 102.297 0 l S Q q 1 0 0 1 42.7697 649.17 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 144.8169 660.3813 cm 0 0 m 68.031 0 l S Q q 1 0 0 1 144.8169 649.17 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 212.8484 660.3813 cm 0 0 m 68.031 0 l S Q q 1 0 0 1 212.8484 649.17 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 280.8799 660.3813 cm 0 0 m 39.685 0 l S Q q 1 0 0 1 280.8799 649.17 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 320.565 660.3813 cm 0 0 m 68.031 0 l S Q q 1 0 0 1 320.565 649.17 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 388.5965 660.3813 cm 0 0 m 68.031 0 l S Q q 1 0 0 1 388.5965 649.17 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 456.628 660.3813 cm 0 0 m 39.935 0 l S Q q 1 0 0 1 456.628 649.17 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 649.17 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 648.92 cm 0 0 m 102.297 0 l S Q q 1 0 0 1 42.7697 637.7087 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 144.8169 648.92 cm 0 0 m 68.031 0 l S Q q 1 0 0 1 144.8169 637.7087 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 212.8484 648.92 cm 0 0 m 68.031 0 l S Q q 1 0 0 1 212.8484 637.7087 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 280.8799 648.92 cm 0 0 m 39.685 0 l S Q q 1 0 0 1 280.8799 637.7087 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 320.565 648.92 cm 0 0 m 68.031 0 l S Q q 1 0 0 1 320.565 637.7087 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 388.5965 648.92 cm 0 0 m 68.031 0 l S Q q 1 0 0 1 388.5965 637.7087 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 456.628 648.92 cm 0 0 m 39.935 0 l S Q q 1 0 0 1 456.628 637.7087 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 637.7087 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 637.4587 cm 0 0 m 102.297 0 l S Q q 1 0 0 1 144.8169 637.4587 cm 0 0 m 68.031 0 l S Q q 1 0 0 1 212.8484 637.4587 cm 0 0 m 68.031 0 l S Q q 1 0 0 1 280.8799 637.4587 cm 0 0 m 39.685 0 l S Q q 1 0 0 1 320.565 637.4587 cm 0 0 m 68.031 0 l S Q q 1 0 0 1 388.5965 637.4587 cm 0 0 m 68.031 0 l S Q q 1 0 0 1 456.628 637.4587 cm 0 0 m 39.935 0 l S Q BT /GS1 gs /T1_4 1 Tf 8 0 0 8 62.0657 694.8118 Tm (\034\213\214\r\b\r\b\t\235 \003\002\b\210\217\004 )Tj -1.144 -1.2 Td (\b\210\003\006\r\b\b\r\n\002 \004\b\004\f\001\b\002\n\002 )Tj 2.768 -1.2 Td (\217\226\t\b\220\003\r\006\004)Tj 12.033 2.517 Td (7 \217\210\003\220\t \212\002\217\f\r \002\212\r\006\004\204\t\t)Tj /T1_3 1 Tf 15.916 -1.316 Td (\n)Tj /T1_4 1 Tf 5.775 1.316 Td (45 \217\210\003\220\t \212\002\217\f\r \002\212\r\006\004\204\t\t)Tj /T1_3 1 Tf 16.194 -1.316 Td (\n)Tj /T1_4 1 Tf -37.844 -0.117 Td (\021\037\031)Tj -0.489 -1.2 Td (N)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (48)Tj 9.039 1.2 Td (\225\200\255)Tj -0.535 -1.2 Td (N)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (46)Tj 13.954 1.2 Td (\021\037\031)Tj -0.489 -1.2 Td (N)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (48)Tj 9.039 1.2 Td (\225\200\255)Tj -0.535 -1.2 Td (N)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (46)Tj /T1_1 1 Tf -45.738 -1.433 Td (\221\023\026\n)Tj 14.695 0 Td (3)Tj /Span<>> BDC ( )Tj EMC (\(6,25%\))Tj 8.254 0 Td (12)Tj /Span<>> BDC ( )Tj EMC (\(26,1%\))Tj 8.098 0 Td (0,01)Tj 5.616 0 Td (5)Tj /Span<>> BDC ( )Tj EMC (\(10,4%\))Tj 8.254 0 Td (10)Tj /Span<>> BDC ( )Tj EMC (\(21,7%\))Tj 8.098 0 Td (0,27)Tj -53.016 -1.433 Td (\203\024\030\n\026)Tj 14.445 0 Td (7)Tj /Span<>> BDC ( )Tj EMC (\(14,65%\))Tj 8.504 0 Td (14)Tj /Span<>> BDC ( )Tj EMC (\(30,4%\))Tj 8.098 0 Td (0,05)Tj 5.366 0 Td (23)Tj /Span<>> BDC ( )Tj EMC (\(47,9%\))Tj 8.504 0 Td (24)Tj /Span<>> BDC ( )Tj EMC (\(52,2%\))Tj 8.098 0 Td (0,41)Tj -53.016 -1.433 Td (\221\027\017\032\036\027\017\036)Tj 14.445 0 Td (38)Tj /Span<>> BDC ( )Tj EMC (\(79,1%\))Tj 8.504 0 Td (20)Tj /Span<>> BDC ( )Tj EMC (\(43,5%\))Tj 8.098 0 Td (0,09)Tj 5.366 0 Td (20)Tj /Span<>> BDC ( )Tj EMC (\(41,7%\))Tj 8.504 0 Td (12)Tj /Span<>> BDC ( )Tj EMC (\(26,1%\))Tj 8.098 0 Td (0,25)Tj ET q 274.961 133.396 221.102 243.826 re W n q /GS0 gs 221.1023475 0 0 243.9087937 274.9606228 133.3138675 cm /Im1 Do Q Q BT 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 0.3 Tw 9 0 0 9 274.9606 122.5959 Tm [(\022\t\217\210\b\002\220 )0.5(4.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf [( )0.5(\240\026\013\t\025\003\026\023\022\021\n\031 )0.5(\030\026\027\023\031\021\025\031 )0.5(\027)]TJ /Span<>> BDC ( )Tj EMC 17.264 0 Td [(\026\021\026\023\022\021\n\003 )0.5(\013\026\021\026\023\031 )]TJ 0.041 Tw -17.264 -1.2 Td (\027)Tj /Span<>> BDC ( )Tj EMC (\033\n\013\n\031 \030\n)Tj /Span<>> BDC ( )Tj EMC (\n\033\031\032\026\203\025\025, \021\026)Tj /Span<>> BDC ( )Tj EMC (7 \025)Tj /Span<>> BDC ( )Tj EMC (45 \t\205\024\013\025 \033\n\t\023\031 \n\033\031\032\026\203\025\025 \205\ )Tj /Span<>> BDC ( )Tj EMC (\033\026)Tj 0 Tw (-)Tj T* (\203\025\031\021\024\n\027 \t\032\026\027\021\025\027\026\031\003\020\004\ \202\032\205\033\033)Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf -0.004 Tw T* [(F)-16(igure 4.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf [( Maximal p)45.9(ressure in the anal canal at rest before sur)]TJ 0 Tw 24.271 0 Td (-)Tj -24.271 -1.2 Td [(g)12(er)-43(y)42(, on the 7th and 45th d)26.2(ays af)-46(ter surg)12.1(er)-43(y)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\033\030\031\030\213\b)-20.9(\035\231\213\233\t \021\032)50(\b)42(\032\231\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj /T1_5 1 Tf 25 0 0 25 512.9769 56.0378 Tm (47)Tj ET endstream endobj 2127 0 obj <>stream Adobed     '$''''$25552;;;;;;;;;;   ####''',,,   ####''',,,   ####''',,,""  w!1"AQ2Ra#3Tb$Sq B %&'()*456789:CDEFGHIJUVWXYZcdefghijrstuvwxyz!1A"Qa2#RqB$ %&'()*3456789:CDEFGHIJSTUVWXYZbcdefghijrstuvwxyz?Ral7)upY"ع͑Ōhe3,mH%1E[yIOx%*6KU45z(gc3#dۃtqmy+밸!!#LٛsSO[b|cGXX31000gU,7jR,ѭ_ ,yGy/᧒N1J)EVbTtL[9Z;ڎ=j}VSRqVV$m##\߻Xw~K֥љu,딹^Zûz\9krzԷ3.e_r+Xw~K֧-a.OZFeb cC+4{+s cK#Z.Id8of]h9I+[${Rxyorz;wRh̺AWhe~Əu\-a.OZw=j[Y2 K;wSޗ'K}21Y_=)r%'ŗ *}Li" cc\H; 9@)Rb*+޼U{ؗl[#3_=ir"! pBz* w#h;nԐ$ $nc4I<$kɿH cF8xXxکASy6nU 펬LFLO=o7RRRBYEoy=%z/gÕb*Җv ƒ#%фTc[$5DPHD@DDD@DDD@DDD@DDD@DD S.^{/XtO_ّ6ֿ#Ҵ`b[瞢(ay"c3f٪NTC*pke*joDYI"6pAuX]9ؑO<~Ė61*3#mer֫Svp8\&|6,q¸$<7J5'lꨖ٘{}Y.y⨌>7p."6Yf{GY6 LO@nd dphAY1쑹psNp kT$)z?^^ Rb*+޶-/r 9}oZf8sCZpE;Z .Xl#6#gm_d|:5ɮ"${#8[&4t4X, DDD@DDD@DDD@DDD@DDD@;/^,S.^Ռݙik203hӴzn 97.4 208gޤ%CˈHl:Z,>etX#hkk$|#a8N7qq[(83q q* BJh)ib,Q41~]OIQLclxywE}s^Ek6q41Ded-p\䕱CԱ')[88"3Ózh4k%7;^!idB,[ m1}Ds[h'1ĶnikxVZʡn'1 cȔp8I8%[WUSG,H(0.sl $,W8XRwJޛo-q,\9(t0[W!M-+OۤNZ9&""" """ """ """ bt z)}Gׯj\ݙik203d`մƱxq)E(6f.k͛ʆWm\TZ:(a?d[qu57D#x”v|cSQɫM,ogϝ K</4cIyԣHG0 Ap=#f9Ag$G5zPڍމnɺGd1! h:Gh旒^ʶ>Tݡ``y%}b`kk{p Rb*+޵b[.zZ[nN)OۓlIf1xz06/SZf+RHW |8l+⫍pšдs׾=@vJ!-.~f7=Ÿ!bUUQLSɝ!FԵv*ڦRsY;QƆd*r|4ND9KQ-Cj&vydx't\Q W{2{uǺk, a6xkXOQW;]Ҩݡ)&u 6( -<:ГWS.A4X˘\cV&'_u!D702HpmKKsQӥ| I=/2V2Mo꘭/+|$Ep67R1;?n׹keH8?s}㗢. V6V 9ڋy aX=~ C5PciCbӛ)p"A֨GO ,ҕw>? 7RMzv̙*̴:umrn9^뒪&(>pD@DDD@DDD@DDD@DD S.^;/Xː[8m?fFpŽִʈ([ Hn7rީqܡU6wJ=&%a IC r]MLch-{]ubSڇDXF8X3gZ3uj8Yv3&WU@ ن{]RߤKV)6Jz%<q,`sΰwϖp7#_[$y[nrela/svۯr=)&=3Sg q 5hu& N8";d6/k]`|:-:+Q^q8||Ea[tZO^F8Xxx\dI&d.O̼RǞyPXx0ӓ&G;S0}cX֗ sX`7cŝ][6)\D7sUz?e{O. oWs AǍ i WK{b'k BU[X&s_$4Rʯlg_Fg_@"ίf~f~B/>ίlg_Fg_@"ʯf~f~B/>ʯlg_Fg_@"ίf~f~B]yU~FeWoto3?BOr3?BOreWoto6U~F3/#3/ zyu~FeWoto3?BOr3?BOrgWoto6u~F3/#3/ zkꪍaɜ#Ir0S\}[ə{{ N򫥩C`ϲ7ƛ:k{|i{{gWoto6u~F3/#3/ zyU~FeWoto3?BOr3?BOreWoto6u~F3/#3/ zyU~FeWotoM"Or3?BOrN(y_e5ڵYCrMbbLO_٢`lIUw״j|:l>(|K|3$(Ԣ馶i<8m=;!K呆k-,;ܵ4\S{En71X7c>_rW8jQ{4tUR<ЃvwM#q޸PbZ2b㨐F-i Լ_( Ȁok[ G6(c%REm\j,w )ە|>G?3ʽ>S9qʹq]a_D j zv~r*v6p%~{ZĆi" """ |ѓe~hda6pZHx8k3v٤i͐fpK[Z :I,G39]8-4 9hP/((M٪Ulۃ(Y(Ni4uѶxo(ޝ^kqnͮRM", D@DD S.^;/X-ٜ6֟DO_ّд֖5o!2?eHGrSWOŪe4Β))[hpx-i>lI<3 xnPĚTe7&B$Sj3˅x:\>&#!e,6.Rl@-m-r5ѡ mmHJ" ?^EW{ׂ؊{ dbfk35_[֙DD$ra[#+d|n2AsL2[;+iuߨ7@ Kz'GMzzftcPiDrΝ,OZaګl p/}&ڀoK(`cMYQXn,'57"ޚ "0ܧ'յ&+֖,lRZ#j(idXTɵ1.qՠ ң22#RS-9Hk]3| AHM:6jH@c"[`w0|q^`dhb sjO :8g{P$8ipJ\Vb`58v+d'D;y`&jBa CbcE3otW]md4U_gt޺p@3–6$pY$fnKz#!X)㈴4n.nnNc{1k 'XÇqOI[nRNmjj\Nj3pn3Üq!%Qm:igKzOUa^f_[֙/L""uKMώIX]2w- D&IV>Rd\" VEVI1b=x:꤮,@TX9W(-=alEU$qgnfAF|+%-2U^gZ#rA#iqNXj`owq[ TI8{5 ؀5PIv]H^OQLBXzAJN`,;2LnxDŽ k6kNԴ5Z3,ŲR1׶V㝧txpqzGr-T1DDE D@DDD@]GI]W6D~.({º0m/؈S/edsֈ /Xnc^:Ok:̘";/^,S.^Ռݙik203d`ҴʅbX,xê8AHkc\@pjT&0jfh(tZNn%ww(GJ2Rcqj5qmUM#qXrēp,(OIC5ttIQ4ѵRZ ·UqI,љ :@IU#c@#+@ԋ ,ȺZ8Ş9IJ8ΰ۔ZIֺm++ٞz2q$ \- PFi-s8\܀ )oGnFZ;$00^+qU898x(=Si0gCJ8)E4TʥWW)[^b&6H!7;]CxKzlfبi$5r nڗwPY"7wPKvC.ڲDcwuԻj;R$@7wPKvC.Ud&pu-v֧!^j"lNEt8pE:eZ5/ɐ$bhslA VτJ5!7tw{*4.cÆ]SޚdV͓ zWLZ.ANۚ2^`x0ǗMZش\wkwuzGjEW`iX;Kz"qYbRj{dr~`zD]^]CdwuՒ ɈVI*2{X_W8@5Zc2ƚssw *a4c k70\/bn&H6ki˘ HqXݺmRZЇ<8I'*Mu΍Z,.Qm^M5`O8zQ}+RWތ8\Im)<[Zc^uڝVXl ܙZIhv؍l px92xČb۷,8U,ْFwu^S5 $2o&yMmE`s^K5'QJbX65'Qoiv%SPTk_Iٵj]Ch?T <21ZR X'.vo̸LtQՑ*M=#͓ff HW7]24'$k m^MWٶ֍QNN4xJQE;iIhISo.ڗwW R` BWհJۥWAvM>]Qw&(Tx\y#:1!};]Y-#4xV򗴾 hM>\͵;W]=e-[Kedi1<բZkF3$;D nڗwW\H]^՗K #|n-,1TKd5ůuEkaIqTg<<97_n.$#I0 J+#7+˺TU5׍2žpi$%tM.'RI[n.zGx(:QQh5B<pANjG{I?i}F)̻tN:}4Mѭ^Otmlж&HHsHlIˊ\PXfV Y䵯klo~:GŋOɟyQ&v^.u Xma뚞ȧ,'ߕ]dFYoVCkZ[w RViofRύ_-zE ='+KVB@C16>Z~Y}[rjژ$~F-cqiʶ0I4O3>0C#= >OuGx1`OĔ0꒪+~B|k7DB-{CaA;VcT%ٖVtR{tc-ߦj"t1Êwt_e5ڼXwE]^ nO_ّ6ֿ#Դ |Z+ ębYq̽wS5 ,ir˶/,VZ-0;'lך%*^9MWjݜ3%>x%O=A{dR=Wxס$zB){U4|kЉ=Hd^q Nwz2G + Wԓf{G840!}M ӭ3KU;=-,),MR8xIT_ JӸe]0Q$/sb<2=l;&Ii']lx55[>6D%G8Gq􆕥8]Nn|6sƟ`8 pc%Ե&sKq10y%Zsս}oI 9 $ ꦧ/4s:`d~q{} %0c|q_(N%5QUMNrLre9 3U?'@^:Ix*I#WJ+ҌWx0NP%:Y˂O+$"7izè䣇iua7$ |M)h~Lx/]^WdWtR̀y`Gc](,؃mqDmmzx?Alʫ31q ^w8/yƽ(NHzq ^ws){U5E9cԆHzq ^wGxi)i)]uPRtRpQR\65?`=Zt#.ie\v"2%2JƸ lMK|KU$3M4. P@ӥ$\zvp*6O[m'h(.cǙ%Gx 55Ysjs836*a<0Dưu4Gje^`қ˽$OQ l&>};zf %Dq&6vI[LzoEy0{RۻwV(cSVN7:M_,gJ\](mqb$eGL^cCqi)9wEB Y"ܰm=39NN1MWWաxE(]WNեW+~bu i;Mik^9[}L:w{n] I7wWQnS\K!\l,e:nc <76)mTlxӔTynWשe?MB]N!KzB.UԎ^HzBe|m㱍^,W.^ՋљE%3DOO٢`մ;}tW6x :[ TǡD85-vm%KX\Ӯ^[3߂pxrpǏÞAK#I|;G>%%8aFqp跫[bY}{N#s{{jq Ѱeih!-xZSP9hvи4syw(|.c1.%b<4.u*yZT<-*+#k*;3J(hhX^(1+ gxll7BE\4-Rةù퍬 [[ `Ζ0Sb7##&oz1M͋ؾ7 x>5 4)9m8-|5q\2qa .l'OI4M#xY9Jxb998[ҽ'\\0|x)K YsQ̺2V=sU{Wj*RvU9Z^#U=Ueu_[֙9|N%liݚc'?,y,y,y,y,y,y,y,y=TuV% *HCYM{ySU\TϰgF7s*> vH9xW+ tx01OW׮+T欥td=XlzʎT0$ћIH?EwUGIYSMUF֙^0-*11#){ۃ,y,(OɾjQj7uI?ɜp8Ap-#_Cһ!.# 1@CZ ѧZVX~rkk1O'&#헹%˕q*J3XG&NmnsNtxxaF2/{ q!Ush{7Q*/xW{q^#6'>_ I{/M8v@x.43r]-,|OJ% | 6{cz. xN?{V\j͏i|dn0wJG~ʳXִ_bEAXKt͕̍kqB*(o? 11aHAܰȞǘI p~6>ÔmT(NS{7 0! IB1RNLZۮBcmE J䭎X""zD/G"½?^EW{Ų1\3b/Lf1xz0DDD@DDD@VYwɱVQaX!c N`57xV>:|#,-M>F? m]@U) X쮳6Vǃf%9I4s{hHԩ=++Ĝ'v蘆kK3tD7.Q0G8_g5 R5x2?QdjiEg oz`m/Iz$ u==gٳ⨄=\llސ^'I%]x{$5tdnCfSTj]+[!xk^9 Bmo 1('dqcޘ2[K^^ IB ^s1> |T-OڧopG>fR>)mKوDEDX8 y+q :v y٤P]85}$tG 2v؃XŚs-5al,wBQI6 5o"eQ2mWꐝ N0QOYO%VT4=/U9BJ4SN36& ;+!6 $nkC} [OM s)hutx: <JWDG3V-،%7QIJJӒZ8KNM>F.ym/*ZOHnB:qQl~-MW!Hȝ& [܏ΧBvR_P:sV^ɋcwTARE C@c.WI6XlFܖc^v8܇j3[SԪ}{ +MZ[ſx )bGqӧ8E֝ZUN \G&Cfx\L0Z~7"9۩$#KNeIZ>Im'$ɕ$\Y= ,jN>;]TkT {2.ٻp;A/S4J *-N2rZc~fB0EmtUY""+}Gׯjbt ze vg O_ّд֒Moc3ZH$MJݪSul4Ub͌MV߹'H' ^X"Si{u2<x~&\>'KxO`Ip1EؑbܺZjRhh7@UKZI]u2>hauD3BH^C'0aLHsXQoY6ZJ}K=qpZgMMjgG#dKlz tpqZg4Ia#K^.5 5`̶5?a ̓,W<7(6g,;7o5zqXx2SW<9ZѩEM>)Rb*+޼U{WfD.~|c`f1xz0DDD@DDD@Z*1&TR5:fssms|ֿmja(fϕRMKT;ޙ|ZFԇ7?:~[OcwP *C paĜ.7x܁Rзba*Ül^7I/x>1bI-z$$j%G]zx*zjb"Ӗ8v<4\bX4Oe9Ԏţnq|מC]:x8roe$Q}a;I4 G,K\3jzz]E5/X\RX2\i=:-<^peFXМ%%뙾)\k$\3mKB' aeM0-5"~ O#].-?eGO5Ƹ؋j/Թ{ pw-nX&vOڦ-al8lN'9ݘ헵up oƚĜғdhklĖ︀a" &M^6%,BS}Dɴf{Üm9:,kXִXt,8;("" WwI1 r/_'|5Ib"! S.^;/X-ٜ6ֿ#8m?}Ѵ7bo|84u yex+\$z~"+m7 ZZa'yca8\0L׾r[Ƹh7]|Q6yE.fߜear7 c̞Gك9F8xp{G5u6^mfE#+\*+(YQM<4DsZlZNJj6Q sc5.+lm|PHbXNXX8W|V\FD\VxQ”mj%/a 84$#(uj9dQZl e|k%|6E4)z?^Y[LV"ʞiWvOmMFk3=erHX+@=e,zŏY\e=edǬlzSW6=erǬ2DqcRǬQX+@=eq Nj42I4Ҁd"Y)a 60l,ytCV,x7IbTjN0ě7ҥ+H4pxRydrFPqEĘE\2F Jx./217ۅDeE..XKdvK5/IF+jV'TA襖6G/FB9H w[@W^m꥝.,ocuDʼnqsXrO>mzLbŒ 7Y>TxW-#Pw#"{`}\ '(x#X*^%+m-Vxڮ;7 N#xXN-aEEb;^; b"! S.^;/X-ٜ6ֿ#8m?fFӴʯ1Jm][X}b" {m*PlQc㭪#$ #h˒l ܰYx^/OYc,I9F [ʴRϔ; axbcy,kn-_ʫ2RzU8 6p_SkؼlGha%m5t/R=ߦJ gn0xN70M&xV4?&p}g }ތQހ""" """  e%{ch֏DkX4y17Wv/<0RMcr:PA!qij#<%кZZy9٘ae:IjJ@i^Q۩ܵ,LE OJM9\ZIk"mKZx_CK9w.*wRD@ˣk׵xN?{V23d`g Դ֖4TEK<Ԧ9xktKܠ-rVfx0a9 kV֢[_QC'aaerʰq^2gimsR|?',HͥXhKiQuLCS3"li` nЗ.1 k".M9!kV fvwşfݥxR8|@5Niq ;Η.#p[JJMwp7 ?jcTV]fw59G\-YiOTcY˸;jijJ槆 vΨA+߄V-E$SLXIK\/BAbö":Zzbqlf["TUb8&6(ݜ1Η$v됮 xLIb`bbLJ$cyQzje^/ 18iMK%8.[EiZ8X004 $bgI%kUen.xsf$T7PRTJ=/G"½W_JʜV46* s s~|b`mĎ)z)]ƣ$X<=H"(Q@H<=x{P,rjedڙG"(Q@H<=x{P,rjedڙG"(Q@H<=x{P,rjedڙGUI'¸4S=ZpʷMso$Aq wfz0j0%+p"ZZA:Jޣ;JRf?,UjMM=V饪ӬFQʭ&'6(<=x{T cx{S($X<=9G2j2EQLڀ cx{S($X<=r<=x{P,rjedڙGŊt_e5ڵ38 EߘVFfvKeEk3d`lÓq+TEձմġy^`#t lFg4A(xT?<݇Ԛ66]ekO5E0WĶ<~a|6e<\ ba/4<cVZt;7p2Ge<7˅Sc5$cvKcmlΤf0 /P'½MUqñ47f7gk!NWWBuڽϸ pT%aœCKG*\%U޴h#ÿa 4&eNM4h/G"Ľ9G"½ % h_=iRQqp I\\%9E\ XK4pD6dm.q`5+hp:PNd@(Kr@(Kr@(Kr@(X>x,p|Kr@(Kr@(Kr@(Kr@(Q ]wE6Pb)F-Ipq;&f&#iJ1bݴ,ή"a~gokiȘ_Y9WQ~x'ـ<\"a~gokkڊUg'蟷cO?nL/w9 ;{]^Au'O۳x ;{]NDx׵e]F~2~v ;q=MjMF*+#O?nίaKkxx%)Mp+zq06$%f-1M6\y ;{]\r.vƽO\Lat.8iٜZִj薒c'蟷cO?n ,~ `.&Rp8ᬱNRq}(JIovz ;{]NExמ)02*MdrU2( 6V.ip+8LfXe`5kKòis}):=E_?D2~vXĎ9χŽLNXJr[x*PT꛾F$p>1G8Ĵ˷fӆ sr<^|%>)x'O۳{KbEEcT[MRqs5}t<8xboIF:k%㝕,HCk{QndEOSWe5J01J*ޮս^ """ "" (*E q m[ " W[9nKNzDDD@DDD@kq\v֥ڶ71kk:8? q<p\2Q&*]5!*S, t?5u ƚB0(C̅ y.qݩ:/R)($|~c;D 2EXrW}.Zo,L)QNҌRU]$5=MDu5&6rlA5`8xQ> ›R˙J6ui#dԸE[$t7;k Y8@׮ LJ<%!-) $u@% ,{s;K#錷uo+a]:8cvk] x3„)^#O]XYyW%F~*O~D(JM)ɤG]"oNI+1,-,t%i:DWQЉj n޲ "h)+phIW5f UɈnd8B^ muɭzYqX2k整6a`x^Y|v1<^0)xZOJrRUMac|NxQÞ\Pb,6ܵGM%3Tbb-F%HP@b@,3auDTѾy%|.,k].K_ BKQ$v7Xh⃳Gkx)Ie✛Ȩp|ˇ>WbFq!Inz(dX)H)^٢7i ǘ] .wqD>5>۩۴f8.6788Äx\E4NڳO q\G3 c( M{&b|&a8Z +JKN{2 1Nqx̞$T=̕'vo:G0&LeeNktTqD!vpƵ ]h ,+5TqTjal;H &*:^O&67&`:. 9Wk E(]z׹sĜ&4nΎ0\L|),V((漏eFŌxhb,x&΢yiGђv駁Ɲ7kּu85-]l53kCH:eZXxSXR+Oi2W1uű80qb478mr-oZ([]7qxsÓ$'2qpSJk|G!xLT0,LJr,h|7J1U_H|hE8&}t_i[zm:X<KxFIORqaҍUCņᅉ nSΥ'"yU8ej]ILF58n#¼Cv#>#;3k}֦\gl aBBHWshE[6}6ddly7ۥt*!"mlin^* [`-Ŵ2ږEh[~WKÇ$#F ֝'֚3gWI2ǻ̗\&9ħ"ae\y'9[(*J-jտ.HC,g7>!)M%^1armEFt*Wx_0 ibQNTmn~J!/((x3α#J] M柃X-+dd4 YsmIU] ^sQy! }X`;Wa4\zͳNs4\ %`xW:%(^ 9%IMWooDtWW?Ss |KƔiOE-{M8X.2Ü4_[O>eǖ"Ì۞4#,N\Un"o00"Ɗyn)N;sN7vx52*fq͐mM^`i*$0=aV%˜{:QC8Xl6QJeѸF"{A)}z{Npe98goHŖyR9MFrWw<^*(pUzɺn/p<)a4HH' 8oNWۈr [`a7(&hfsO]&A 0$xmsgt< khe&7C19ƛf4x Rnܵ^}riḩc7)>J-M&\\L?6OJJYyVg/j9|HBiM>$>}'OE/E$xJN]-(0jZ:Z74?HnMIw0=d6c>m|^Vq7j](c-f!aEO$sM,{eulۣMŔl]Ҫ|I{c:ΜrMJ-C|LV2Pa8o+XP͛8mqYermhx^&,g,' ZʝUQĖ$,nRJ޺-qxRxX~gR&,!uFmԛDtcsj9_10Zr*xEE{hv1ӴE%d}ٚz)SauAQvQ+\ۼq&=E \t2h̯lmѹgvfQq?C$dC Ӕ\Tr}e&xʹO^fRŔ\p>gv6lv6>',),JrX-FSymkT'h`11 圖e6wf! @14]zef-DZepq.Yv?s)tuR NF s' XJfs Nwnn"MiCoQqJK~9i()F5 X8G9bGCqZIN-kQNPxL| `7E)x,*wJYDCN$K?xrJrY։ 'SISQ)\#pkyojqakH!l0hq#p$.jxG6wN7T2. p *r_u듢ٮB<Kv{f /n9]>t/aI|Z8Kec˅l8gĩ&QM Zz(myח'ax8 2gܤEJթE5VGPqlpg5WX:QX~ TPPU=9KY)#d3qz[y#7jN3|~q^ގ/p8,^+1e G99)TJ1zhіJo 4x78ǂI+'m7uh9/ϩc̠?>AeZloŰ'hCgO"[Wx}apR#%yqpZēxY)&rr*b7`p15qx1:%>+Wn=+j:qOuD`TEQl9skf: {i0 h.nWk{2ŋp+K>%5.%N#9>stream Adobed     '$''''$25552;;;;;;;;;;   ####''',,,   ####''',,,   ####''',,,""   i!"1QAaSq#23BT$ %&'()*4Rbr56789:CDEFGHIJUVWXYZcdefghijstuvwxyz!1A"2QaBq#Rb $%&'()*3456789:CDEFGHIJSTUVWXYZcdefghijrstuvwxyz?)Jy"!_g/(0\N`FpeǍ\wJ[I]jSӮN)o=98*E(%Ӳl拜ͧztO!H6t6D3uĿR-ɇgۨ=c]Q*8%CXt' %[K kf a .:Tv {MWrVb;K.:jgKlR+]^[)s\Zdiژ9tYLr"dߓ姬'W**T;yi1D!:$6#1֌J&SvE*m{xZCjc8C-0L.CG6͠K#|c43ę~ˆݡR^438Za֕Z.4[mJЏvM/:L* I_XH 8H=6!C'Z> {m~=۟STQC<)^mϿ= O4UC<)^mϿ= O4UC=b<{6 km~y[芑GpP0I*>K)I/§s*a/§s*a/§s*aF) `.>|{Yyt!T*M;wU7W\G \'&Yتa$h3o2[ۭ"X] !AcLJNDLyDyuZԭOb~3Y8I.,~pr|rTI/~3V:Ēa 2Vt("SAֿ,>_\JZ*ʣ_"G#> G#> 攥J""%+I≑$uV'3ꮢmf&<1gDDRL'`s= LY{R$ɞ[pps])JQjkZpߴ܂ (&hvz$ԯ]\4\]f|uҳSe=' 7Tv1W =2p1sgJRYrDD)DDDJRDDD)DDDJRDDD)DDDJRDDD)DDDJRDDD)DDDJRDDD)DDDJRDDD)DDDJRDDD)DDDJRDDD)DDDP/-ǧjmCl?AW ƺ7/jKpBT&-X8VVٱ5Sq/ |nr@õ -ZhmlmЦ6`zjQ/:ߴѢ{5mF\cÄ0bs\թZ}W<%2mثס,_Sޑwh]uZ$ϷkVqs-RAV*TD\3DDDP.q-N?ҖۗFEҏF}5ҏF}5)JDDUr<8N]RT#OOwa=Ėj%G2wwMUjH##<YaA uYv%UUg{Z+1.iQw_g c*C 3 L/?5ThYޅ6;^"*uF]k6J KZ2[{wF-lu{:O,CHT}ZY5ߍ+AyqpdK9#dh:dcޭ'@i;DzOYV:E{6Y%X"rJį8S4(P؀gWvck:vFOrZF񦛭,қ۰v1[ `cg Z[ܤY(2lϘzIZoö^WXݛ0FzMH"ӠX>[9r6vkvu9.}&isӋkCݎgYJj=sC]]htI&*BZ"e&ֵZت0 a0&WʚMñª'ѹj\P\D&#wQu.q-OfS.3KSkD<:d`؅z?!\ƛƻRJ""|j VFO֬!P""|i|k*Q]M]DDD]w7v@V_eۯXJơ߳a*Tl!JEzzjT*".ƛƻR_o_J"""|i|k(Ԣ"".ƛƻR_o_J"""|i|k(Ԣ"".ƛƻR_o_J"""|i|k(Ԣ"".ƛƻR_o_J"""|i|k(Ԣ"".ƛƻR}b[2!D4^\B9 ^ ֮U;%P]=vj%Ηi $PJ JPjF;H[ҕ 5{)5"}fGۂ YcD]m.aP6&dy)8m& #q2buB}ŷ\݋EIT<Sb 3={(*$.(UuJT;g> ]@?њ9$H W)PJDKY|͈Ȓ$H Ne/Z?|>ܓ_ YgAs](gAs\ҔDDDZ2~ 6j߈8Zՙ4py0mk$q%6:jc2>!հ/{Z`6c.,mMqb@r+&2*a"iکe )A}>m̫u>*RDkH;]') Tr"Iŝ^].7,CvHml֥ZK]7DHV7a%HEXۻcƵxuWaqvR\-X'wDֽn &U*$uB}̑U<({nO>bgԓWǸH1o" ` Eu-H`2s=0qH{E}OR-HFá QҠ컚G5eBʌnߴ5־m |4PPH#Jc:wb%i1Y#Fܐ13w=uoJS+v":lQ3WGmf-.Ikp :t3s"-ܞ{nr;׻¥iAɖQ>CD|IL% .\Gh1x1RZ&-iTsE؏]aj߳a*Tlݧ!JE׷=tx]vB""vRoԢ""._z([zJ"""vRoԢ"".kz(kzJ"""eRԢ"".oz(kzJ"""eRԢ"".[z([zJ"""vڔDDEWt'XWDm'gmՕCl?lʫk]XT$@Z&l.S}u\ey)Ǒ3wh>jьFԘywq^8f }Pj/))cb/Q9 nkv@=p!=rY6MBH RL$>vԧLc p\ZL\5{d׉p!O)P""R""(Z?ҖTk˟_KSFEҏF}5ҏF}5)JDDXn(R}~ q"""?-U:oMSjN >WB""R""%)J"""R""%)J"""R""%)J"""R""%)J"""R""%)J"""R""%)J"""R""%)J"""R""%)J"""R""(7H52~Z6M ʫ toOe5Ѽ=\&2)1ZivTO r$#I'ܪ.0d0"$g$y*φẆO)92ILۚ4cSPxl]ү) dZLH K\A\vS5Sci5րwէE}VHӨC]o)emu#QC(kk@s k^'UmJULZXD6N!ʰ] ҢaI0"-NDlmڅջl.ncZZKnn] ΂ڕIkYBSwlٍg>5&߉5G4a("@Mz[$C/XmuFTqB )<`zyT@g<*33 W4~TDJRDDD)DDDJRnˋiLlQlU G}>"W* mE$HE4B0B3F3u5UZ3o$$na}#2u'=*`qzꪢN7 sZ&F!0f&l2.eÚs- oR *"%)J"""R""%)J"""R""%)J"""R""%)J"""R""%)J"""RhW""%)J"""yh~=7S*a L5Ѽ=\F?}ukt5DZ# 峻֮Y\̏7 eOi4 *Fu-Xg)*o ka2M =ԯ I#nP]2PxlCԤ65A8F&IL]gû@]]As{FqCmV͍M_chsNyi1slqa_iU&0kqmi0$Wu[ $Ւ F wf U>IXQT MVt=Uv.Ž4I!o9]tmM&HMXJ2Q[=7x*g(L!~n;h٫Pl/EExf5"Rײ{^nAa/ ȁs_aUA%[Co E'$]k˟_KSʚ]ŵX,J?!\hiRNd(i2OpZ.A| 2,#vbV\vNվd[HH\j21G:cD(HcЅ{ :)vy O,{."Hozh\ҿ ~D]JV nw_#[X.RF3SolK!*}=tVv`YUYxoWPo_҅~}/>@73 U޲\Ҿ|ʪ".6 m(›GsJ"""hS w5DR bjP[isv)d(\՜'r.s"7/OSjCpA0INVsIq%ΒNdlI(I? MK"J3玿-;Qߛi?-fP`tI}Os*TA89 DDUN9;!Ӹ3\N5a9JU0qZDKf|6Þ:ݷ6"%cpuS&\"킅+Y\KK e*\ 1T=j]\Dzے~].k .`yIs",]w}U(G[\r 1cf 䇅S]L̨`kkxUB՘y2w$Amk] jM!Ỉq~IĸDDY߹I!AiCFÙ%c'ƧU+F_ahM:hDfQ͔J9(u> .nfnPvmGEXnBAGҮg B5t]J\$*+  ƱzcP.\B61VK9-iOWoOVVQcXI^ 1".[McT8d"'UZdZ})"d.J̊{;yXڂ_Immp߻U)O,.'{pϤh7f\zX],f0ӄEĿ[lN*;J#q|~Y0+8W@ruWm_QQjW]M+}T<RǦ'7/OS* 0Z^X=M=5j舋+}T<vu<R.%-خ-! zo?^zEW"l^E̷wTgH@76s50}:B'".)3Q&ְ؏mY{GdǮ48I#YWPø2 v<JƊH-$ !BJxU7"".ԮSp>"""JxU7""/;Id_Iwk7H׌zǛ_* |ZϳVhEi4iWq|drs+ڴeD5dc]JܨPi6;a,k% 2 J˵U!` ց F£=m|H4 mv{RiQV\W FuUSXio1xǗݮ=o\fxvf``9eϟM[RuGjv]vZn cEjbX$ W:}ZcE-k_]"؆8Z "tR~Ys)juXdJ?!\J?!\4*Q*~'k^^j9%Wۈ)?7U7KivR4sXfvY ak5f@2Z[‡".'U=#YGH3~I^Ul19je+i֢(:iVpG9B"".^] ~veǮfɡRK%3%;]evӀ9Z+48E$Vv ͺoLb=x J:ɓo\gw}v-"n9P17qA+=.Tk5`VcZ\F%Uf '&#IϦ-&Ha>b'V@ *纓6z#lYmZ| 6=2|ek\fp'ʯ+R$DJRDDEѰzT;F鿤Uvh5 h\v"%w8bY;m@#nhV5dlΌWXT=uڴvmQs/P7ch$arCYHwֹ xKWheGjZ).,4[+鞪kV=WM#<֎R٪ ;V.ٴ 1trCuMnхĤ-2B+鞵$xY";%T]lk-0_(.p- % ιʑє#5ynOǔwH*ԇ@G(DEkxU.$@2PGrOsJ|K4R5Ɯ [ <+o|Ek9@z6GFáЉ\'.L5]kU9A!u""]d}PW?'M-o?jX;{7DD^U+J,?gI?Ο:_Z }JOa]mWUG$b[c6o[ھlga uV9E$Օri.fiK \1RUV0A |=9/׃{Vʞ.-wb6b #KA$_M\5)>ᤴΫȓ QII ^La'8\z]BOR) <H- 6 I-^kspu!3험 ]ݍĞ +UhƣFWwF;#1L1M>8)#$c*0,k MkOKLQPGjX%m K&'^{;LN8HFs SPCHiu6c5.}0q4HkoChKۈឆ%OY0 v.K; 0isa a+h}'~M{S/|*&fm\np C'!~&O4 -/ˣauEjx'ȹet>w>`IQR|/|*Wi4鏘""/*y~Sʤ_Uӷ=_i0DD^U'G§IQ߷=_z+H<>`jGnR{"\LXIŠ$siUooyyX"mV¯|?ӷ=_~0Z* m=(ɵAYIQR|/|*Wkelw4鏘""^^T; nV;s9CqrffUPffn2I?d-o*ێ) A%7"Sa"[*71#yVOl3.<K{f-kN-=='Sk*(lVņ;8n5H"xW1y*ܗ@su~nMEp| H( TŇ [!G9GE\5#uĀ~W" #1*q,!}u7N[o.ty&9nNp<w0gXčnn<9ňEUzq_܊n: ޴xZIf* z׶V+r*ƺ>$ xP s=)`k6|uUIu*^? m1Xcm!jB_G>w>HqqKȓ=wqij^ASDQR|/|*x:vOtDL|xyT; T; O7?5HkL$O c?G§IQm>3>#]NmܛvȥaۊPiJ=DD^U'Gª2vNY .P:1de=vUMg7Zr̍ `n;'+Դhz;T/h&ediABR=NGX@JͬcYypIC EdQ'/HOԴ.GKkxt(2`## M4snk9V#IDHӂd0Y]*L ;nezu"~U'Gì67߉gJ֤m#k.,9uRDGQ)P{GQfu鏘""/*h~Ev7ȓ!edV{VZ5DTt#Sݚ^ฐ613tInn&Хܪ`j{g- )Xk ͽyʟy~Sʟ$XPX\>8kk`=hPrI$Mwٶ.[j[M'b9yQX1b|k*y~Sʤ_Uӷ=_0y}1gԬCF-MYUmкőrf`'8UT3*[77]Ơ &"gʹ quEuIv1)]S 우9]gE^b>N( FuA6ܐpX :mخ_dcf|zHT쥆J6˰l"\)X!3ݡkUI*U`$Xle]H<-q,aFL6\qq<8]bö- V+".p+V*.ȩdz&+-*pG0@i3.mM:lOJ~Ys)juU:ϷnCltZ-\>uf댈κQϰQ߰攥*T"%)J"""R""%)J"""R""%)J"""VgCMլ7P+&Ad&A;ޙ 1k%^( >%muE:*ƓXAh.i 0碧GA /=`r2ɤt0\q`R3u=RHϯSZMzD1Iqis];ˑR{ ` m6:Ff׷[/n-EqH4psQ~OI6'Lř:0W >塚(`PYUYcݯ֩QBDwZi{T9'R"RC ]Ng!w?!{qRWcQ(i^FiW7<CHn@Wb$(smsLMO!/J^|SB*V 1>R~FG .6I=/V7(x韖}~B>f҃YV}+80FZB.Cz㗯Oc Kqp?Ԩ /blO#23?I/u]2x;3*M)J%Al?AѰzoU] |kx*{/S}u&jQ )q`TWܸSߌTn{ %6: P[]bt6.HdՆϩZ$IXD莪z0S e* b|?r;lsv4;6 =?):}ЯFVN l="NGA|ܭIʕw``T8=גh]cA$7 κȻї8##fR#{,舫I Bsoߚ,'"PAߒI$y}:W.,J1by Eo-C}Tvu t$ >5.q-Oٌ h"y  JWRܕgAsQ7޾&Ra|M%(Ey]NM総{JG)u6~M総ro=}E)Tے[Q7=ɼ{ҘG_9SnInJG{x&}uH!0rܒܔ"ɼ]NM総{JBa|M%(Ey]NM総{JBa|M%(Eyo":ʛrKrP?&ǽuqɼ]RiH0rܒܔ"agu$ї"lg{gkꇺWpO:[WwCH 7"GX{$qdONmB",hONolNLma\纼RtgO' ~ TslGҞ-)eCSq4Tr*v']J yʻ]\ZwGPr:21j47SZH-q㢰jL ˟hkٜdSn^[R97޾{x^W7VndX nn'UL$*kό$% @$z/93OMǫO@Veĸ;~=]gt%5*;UVXOqjQϴn~ݫ.zHJ|ɁޔM{zW6ַ^U)*sdAT,T[[F`y]NM総JG)u6~M総{ro=}E)Tے[Q7~>?K,zdfy1׼֢\yIu=t~SGb m"șaV}u9usp_Iur'(Y"Yl"QtFһez"|o_{K ,IZo_7 3[!ʋrPǓy]C 緯}us%]TPѺAB Ю:9SnInJejz.BܮԌMƺ{)`ݙpI׳3\Iq}.X2&C[W¢<"C47` {5ChfL_Ow3fvZL`MX+FUu'ƺ7>7hkL 8D/C$wcÓG6+@)%T;WL.,HEw*#8,#w^D1eQfU4ۻ%{jMln",L8`.1~KHo7Tzl)uSZ*UúgvgcwP879c XNiJmXI͍ZCA8<6e{j {ݴm-0X,PCD ,RvuDDD]]v4MvuDDD]]v4Mr{哂n."k7jO,uY&@ @f-M~rT ^ᘃbA9L5m04x9:Zf4~{O5IʢFn4XcS,x.k-U`N_8R$DE\m,픙->e<GqSdl3CD0Adk4{A fFkp m=WUlzń+NɅ !<+4'8SlF:yy';$UѷFA4wjly>Lh/!M7_BZ@^uTS#0D |I gxLG=jhs5! znu{__ʗd*ɾ#U޸G*{5%0YJDDSLg_VԹd-,xBjŪ@Yhw_.L ʣ鑞櫱3,vǨ>SnM,mLJm si Q.urAĹB"PP )n~BIOm/V9T{w F%YC) 5}!|Lr+|"+4E\5]&RGaUewiap< Lʯ%vh5{sjZAl)0p NCJ(^QY1 }fGU';Q[9KfNa*M4puo/HZ_=U_e_Q{(S qh``d0߰}Q%Kg?9UG$&9'8s~G$VA5Ӑy#2+wr̚>~ov\idR Gf|evgTW]65kT""{h~=?SjX b!\UU5쾺1QKLttH(qvubѤ2-FU} BIIfʷ2R"PɳGiupfɕJ 5Zhikxw3{ͼ*)Ee5)DDDP.q-N:?ҖUۗFEҏF}5ҏF}5)JDDJRDDD)DDDJRDDD)DDDJRDDD)DDDJRDDD)DDDJRDDE ?-yfJzPכkj""R""UOlTs9Cހ䏳jF#\vɫ1W9ulT+7_Y8䲛Uw1so"`S KeQJӡxn1uw~iYc 13kK{-=Oծ<2 ~w}bv3L`[H2{E,.'>!mPfz ʃ,Bq_O.XmBvG9k9*+;&UWV6u$CϮ\+CGQQԭ-BUw ]Y3>4E$cbn-  &!I$(cKz XK9%xQdz)rӵ$*X\s $[a"|b㢙J񵹆;v>^Ric\!$*Idiߖ}/"~"O$5NfIo~kE'5 NgƤҔPJR{(V.PL+B*9xQ@.㡎vqTvTqk 9~ gm64 Xg?9UX"3O.7y?Uo ƛg~G$U K7I1u9墦|p1[;BQqD\{e[M-v,36#?71#*AuJ <׭)Jް(DEѰzoT;F鿤Uv~D쾺7hVY],6 ޻#orJɩ!3erX]rE粹>T^+T[C&:q93KidQw0isck@3<{QÍJtP YOf)pJZ]v7 M dӧSc\Ec| c]޸_RZ߁o, 55 s\{MSe.Mؚʅdfi+5 "%+2é\%,;FGQDZRꁭ~Ys)j}]yTkWatasJR)JQ)JQ)JQ)JQBO^o٬_Ҟ$)mZcUO_5yT|]f) 'Yߑz`dE-T+4I r>5t  0G?UUw#L.|I_#ujW1ecm0wW^YY.#WE, ǭ}j_9 Wʗd%ŀM7h/|gfUT&82pK/)yP9(,C=fn4KH6X%Z WpH \0۾$Ii8ݤ4E+ ٸ%iLc `n%:lF}>z1{(ZXS hm! ShkCHKmΊm=mire0 2="ҕ:]v=Z縃bmm$E 9"H^6]H$rV)XT,r⢫oWpTI&AnہHq$W>pq5uɻ6$c*fBL;u y-Åg.jxJNRd q!i98 6`a 8q0 H:-)JʈJRBDzVMS kߐj['DDSEs\ 搡)JQF鿤P?-ǦjeU٠ƺ7kx쾺j|v[ZfߐOuDi-y;ƫλK1^lvaۜgњ_(gu0&4*;A8&wXaYr*BKyӎsFXL.Ƹܾ4ܾ5*Qƺޔ"l-6R~Dx{n3LD7+LdSV9DE4ۗƻRUq|i|kQƛƹq|i|kQ\2Rܾ4ܾ5(M\҈_p읯_Nɿ )}dDE02;ƂDEiDDDUwW0enYpz όUB M5Ս&GE >2.qewsK )HUdJváKU$<IlQxocT\FDcyD=F;ŏ.xYYZ(U[8,J<%ɮvvZtPQ!RUs^Ė⑄ &n1hLS%w57Y.͚~[E⣚}=]aA0m϶5cS`oԙ$ZRUeBֿ,:_\JZWnJ5.~B3 ~B3 iJT""R""%)J"""R""%)J"""R""%)J"""R""%)J"""W(JR(JR>Q' ?,{\|O~Y) <|*""JRB""R""%)J"""R""%)J"""R""%)J"""TJɿ *uAKuȈhk\B""R""(7H52~Z6M ʫAtoOe5Ѽ_]s@LIdZ[2F ;0;J|Ƥȸ~HZDeW*"k/('66qH5?D6V+@<4_(f'eT='Ps^y罕)ksֱ/0 \&@Mi kĂ1o>Fڔȇew1,`egګhxsƵi n@5 OXҔV\)Q;Y>U{ϢeXC6锰 ~H+At*J>7C hd4ZJv)> i;08\:.?ҖT k̟_KS5.T~B3 ~B3 iJT""R""%)J"""R""%)J"""R""%)J"""R""%)J"""R""%)J"""R""%)J"""D7+LdSq?oWgȧ*t|U)JJR(JR(JR(Pn?-+_eӵk*[%Mp+JR~Z6M ʇ{h~=7S*ȃUѼ=\F?}uq5ޝkwk7A#BUHaƥp&Mr*wIgqW,KKc-˜xߖqPEO4dRYGc*3c,Yp*;YW_ ܽJU]+9cpSel9,Ӧi/2*lu:oih!\[஝nN9^Tt=D&Yp1l0iսp$ sJu.]H^X3Lm *TbX\DC^xی q!oIYU$1#8>q"\Ȩ{7d۪6N)g!N*ar$@s6jݴnc˴SU~2ƴ$+Cw{q3ݝR"% &;EU I?ҖUNEgS%ŌtWaqxJDD]{^"]DDD]{^"]DDD]{^"]DDD]{^"]DDD]{^"]DDD]{^"]DDD]{^"]DDD]{^"]DDD]{^"]DDD]{^"]DDD]{^"]DDD]{^"]DDD^7u !^Zfc+~8ߐ3ϷOTS2""xJkS+(kS+(kS+(kS+(kS+(kS+(s67O<\.DulHpU"N=>:Ư^7`v|٬Xjwq$dyU4eE3z*AĤ< p7l-G4T.siWn#'nDIfVo4H4`#kߵ*Z2ʥ \J{#Q 3A jگioFI1'׵)ڔDDEWt..aT99ҫ*yh~=7S*Aufʬr "}UtoOe4qUswj!%ODDRA)JQ""R""%)J"""R""%)J"""R""%)J"""R,Qd82 ǨQ)J"""ɨDmO/"0}ZE',]PSNKXs穴/mFqEj(Sg msD)E(JR(JR(JR49$$9xGүJ"""R""%)J"""R""(7H52Z6M ʫk]S}uto\jڌ]65$cިwz*XtJ]eXsUw[v̗KAն]Zv'O0d퓲7iAsT*luh/8\SEFX ."Lk%*f>#s!|]&4ST0c5Kw[ڵFVMi~X}W$ 0c\6qӿ\ҠȈv^f"IeXr =} RJ@;p{H Q9>=} RR%~={GTEM7ڏ&GU:R%~={GTEM7ڏдV$=} RR%~={GTEM7ڏ&GU:9+#'h=¢(>i~OOa4j?G'©Ԥ_wOi;GtAMr|*{ Q9>N$J{H ;poW lAhIr2t?ES[:,o,zI Gt wFY\56<$m)1}Nڣt` d}} i~OSc >s\#'h=©P Q9>=} RR%~={GTEM7ڏ&GU:9+#'h=¢(>i~OOa4j?G'©Ԥ_wOi;GtAMr|*{ Q9>N$J{H ;poSM7ڏu)% rWGN={DP}} i~OSI)h=v#*".GTMr|*Uz-%vFUAi%A^GtwOiQh)2VvػQ1 b7YQiaH-uM7ڏT!{(Y!$ԜւQ52=} Cqijheg%q9OX)eva,I}>w T@GtwOioO˨8=v]f@ i1,CgMza>dMr|*{ Q9>ExUnRnE -#Aҽ^Ӟ^J;$ۺQ\Ʃʽ{H ;p>B+9;U5Hl$O-Vn&S 8I;K OPD Yz"[MJKm{Z#63|*Pרir00q́'ιvzYI^"-iƹ )Jy"%)J"""R""%)J"""R""%)J"""R""(,-k T]3O#P%[aA ƨ{ҔQ VTÈ4ݤČq"˶[gs[KeR6ڼTy{fְ Zs'5"%)J"""R""%)J"""R""%)J"""R""%B{VPf8m4O> xw TT4]H`]i'Az%)J)DDJR(JR(JR(U:Z;¬:&:'[RD틺le" UN 1Xhz(ΑYZ] VZQO~}*L]:$b$'jU*I%@h {vT6w9jci28A %zW 7/{u\+,/.OF+*KH#0g̡Y4v%vkx y@{tk%[ɾeInˣbi+ Oy=pr>1_On6vwhZ OS+vL)Pfu^e=3h.[n'5T ZIcic:RdKg5ÑhV6V)즻ej\_7q núcg3YJZ{R긪\.njmY)m< ^ ^5][%S~cy#Ld\v݀:cH3KHЮxݸBRmVir+)P#A2;Z/]o9W"7I1"˽=&$GRO޲u'Tm‹U &qXi 3HoU4)xojsK)1 LD櫲YBvF:Hk*vUkjk^"ZsY~՛F_EkU{70s*4`B~%V[sei5\$2W PM 9t| iTʠae;Ӵ l.w"`9;yDɮ-A#I{X d<zQkhڨ͠7Jq[c&L{1ShT /N\FC\RԪ1{7UגKC)1̧M"wClm3Z*QocvX0C~)+I(gee Y@um jAeS536Ap8Ń'+b4BT{5uB\o`샎X~TenYkKZ`&`kFqU}צͨ6 Tb|2ok"ZڪVpU50Xpؙt݊TǢY:ZݠҤ\404Ŕ-Տ.I!gpGw`OC GUM;OFҩ1H LzwRKV[8NP RHu 9,D < `:R'UeG|Di{5ejs`xcٻhMJkprij5Nf/_]*`F0]!hyIl SNbc#bN%&S\9S#$ǛeK6I¸D['ucxnYjC$ 6+GClas^W:DfLҭRuq0I$Jx$J7Vw2wl*mT;u Z;:8sH"6#Z6z%=hm/vU'cv!) u=\ڛͪp665Rn8ۼ`'xK4C R?fECG3mB:Q bӿvRM 0.A{;y}!QkG CkݶѧV*9S/MX KiG]ѧUjn/-cirOjE'9/3ڰD{*)i_+FsTtz/ou -cT}Fl e ^Ldě~uvU)#!ޤ_Ay]YƱ)6RI"7SS:40.w컎T]ѵo*]0,<¤(Ӯ#$ޑY%`s$Xtcܥ~ϱl)w?f]ZRk Z nO& u-e/ҭUKEsYZ` u)]ydlvZ*lsC"\QF&/" ȳ\6P~&5* D `*;Nn4i}Ema+Rٰ⬭4Rr~6FDb@>'ckET(-B;jT`FE|#-AI9Y j];iRn^4\sG0C:bѴl0l5q6qLA 좖ٺ4ecs GȀUeu>dٍ VPMi ٹJIui󙡒H%>-+juWٳ6s4BXQٕaUlָx&<.kgFMkZ<"'ʹ)J(JR(JR(JR)Jy"%)J"""R""%)J"""R""%)J"""R""%)J"""R""%)J"""q>c лǺ|1b6@Ni(T!'~e#٭l]ga?#_+X8d[>퉯I{P"@UfUf;!H* 9+i"Ҿ>-m< :06( IjOam%#X!dwשGHN^GeP6 5M>%Yw%ΧsTQhZ0v>Tch<ѧ5ñ.nK@$l [FYjol6II88-lNf/ַvZyD팮N*.8u6A5eoUѻ&FBȽK.q{ߊ4ȂĬ$'=&![3A$Eٖ0; j+R.e kXRX` :Y${Ru&&eZokn<>Iw3iً7v *ԫ ~opi:~KCve}'lݻ)T+5Rv,,Lֽ+Ahbdf.sj I~QlOY[;31.#a;AϚL0wO& dIL1*1<>R4sewm*1Ңpީv ռpI._&F-OVIw%~dqXǪ龓 ܸ1Ө[sh HsewUTa=Q cZ-"a9M}5F촘6ZKJUe:deEӵ=QHR*4D_reֲsw[4kNH{s*;s$~s:TmB{]7]M]:l 0GLym{ mّSRNe npH;*3 wGc@ v:n(ea7i IWV2~2w13s,q62($;d 2{z}{1,lI;>j4yZSIܲ(=;yMސ;{& _#/-I\?ia{=6}S/Okm\@@Z:.aT]38̺1:kBӆHKg{"զUaX(10XH N$TmWd]1d̡bDca.2\dWƏw- WcZN:R)ʑ5O.@v\ք~ r5=(Ⱥ^a9(svVeAµ'S$Ii .UfƱ hguajOo|4;)SX?{i!8e"&EW:viْU\+<[#]oJ[.|DHK22=&4ieHeG"dvZ%NΨCkQȵ.kPUlhTnwX\b MmJNcReհ%ye+Q'i-/6GʻI&95ybG GZL wYKo}conddBgUWZ&W6-hnmF+Ճ:w)EEnխu+KpE)bp׺YKx؆ 8 Fs8bҸӤJ3I !Z[5GPv*5mJujRk\]LA$felv~mjL)S;2dYHRqs{ 'ld*ۀ ƥ-DBGNȰ>GӬīϲZ'@<=>YK)}:Jݣk0S!oDNCXO$ySHvvGqwoé~CY@/>D1wiJQt\)JQ)JQ)JQ)JQ)Jy"%)J"""R""%)J"""R""%)J"""R""%)J"""R""%)J"""ʭр#]yq_PBkpL0`w.z:j]Gî5jTkP@c}TYQsǦk}Be\i=q<]c\ fyipszU^/ G$ff1~/wqSmǺM2ń O?+"\Ě+'^!6rr!go1rXlW͢M{^M\dWԟXڂh5.6HTwqAFaVs;Nê«NjCKzhAP cK\숷 mou܃&#& rG-H=:)+ʻ3zvH;7 ǯ>nغ*VN5]z-`զMkOۇRqh !N23bZWC[O'-AO,ݫubqFjwd.Es`1E2aP0\=0>$'z]QبTMjEznikw]Q^fq"f Ou{6:RU)NB"qS:d(FHɬRkZizd餓Sm".Xp`3Ϣ˫k[XZBw"]q%*aʀ6=F[j "z#$0R #5Ⱦ*m}3HQfT.{XP4;'VٙR*"H\-|sXxxYamfi4U匒 ;ЮflntZ, 8.alς`ǍRr}_B/S~ףS TsM쀒r_ Lm4iR*܆{RU+2"%)J"""R""%)J"""R""%)J"""R"" )Jy"%)J"""R""%)J"""R""%)J"""R""%)J"""R""%)J"""R""%u1FdS"7{=]DE8H$ML$Evf,QJ=Kg>zl-&@$D1 0S)DXs^pqd,+QVΒ4b260bB rU~CNEp֖ l WTu+֕) 3s<\}TF-q CIdL "9b*;\Č%3*~: :zRG\\H$<= 80M+UEv|)G9Xs "N`W׭(v{>˴g38'Uۇ34[%T^ ce;o ZZc2C~VY>ʽiRGWֺ)\Hleh荭USW4]^(*dEr v^mij/ mfBPI5JRD#$r=V\׹h88"y ʷ-s*hʃNt66LZ"J(*:tDlo!$ID<ȓVꉊq{YĂRLT><3⸎/1vYTP~:׭*RZ7`pb8ge({"H|Jաv3{mL(@^HW5^NC* N7$όj>B(ױ;wz+#Aj*;sJ"{ݛ\s>3A%Ēd$PJR(JR(JR(JR endstream endobj 2176 0 obj <>stream endstream endobj 2175 0 obj <>stream endstream endobj 2123 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.086 Tw 10 0 0 10 70.8661 724.8299 Tm (\n\036\021\024\007\026 \035\017\022\r\017\007\026\006\017\017 \f\023\026\ \n\026 \r\t\023\024\035\027\016\035\026\f\034 \025\037\212 \026\027\026\ \035\034)Tj 0 Tw (-)Tj 0.385 Tw 0 -1.218 TD [(\027\024\020\024 \f\235\017\027\022\021\036\030\026 \023\030\017\002\024\ \030\024\n \230\202\212. ht)-30(tps://www.stqr.)]TJ 0 Tw T* [(r)-22(u/84651-2-088 \(\f\f\t\035\022\026 \027\026)]TJ /Span<>> BDC ( )Tj EMC (QR-\022\024\007 \017)Tj /Span<>> BDC ( )Tj EMC (\r\017\007\036\024\).)Tj ET q /GS0 gs 84.7543615 0 0 83.404293 70.8661345 606.5656613 cm /Im0 Do Q BT /T1_0 1 Tf 0.365 Tw 10 0 0 10 70.8661 590.8719 Tm [(\025\024\027\031\f\024\024\002\030\026\027\t\005 )0.6(\030\026\f\001\017\030\017\021\036\035\034 )0.6(\023\030\017\002\024\030\026, )0.5(\023\030\036\007\r\026\030\017)]TJ 0 Tw (-)Tj -0.009 Tw T* (\021\036\035\034\027\024 \r\007\036\021\t\005 \r)Tj /Span<>> BDC ( )Tj EMC (\f\021\036\030\017\035\034\027\031\033 \b\017\030\031\030\020\017\004\036\ \f\022\031\033 \023\036\030\004\026\021\022\031 )Tj 0.323 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\024\002\030\026\002\024\021\026\027\027\t\005 \r\026\036\035\017\027\024\ \r\t\n \n\026\f\035\024\n, \r\030\026\013\026\021\036\035\034)Tj 0 Tw (-)Tj 0.265 Tw T* [(\027\t\n\017 \007\r\017\032\036\027\017\016\n\017, )0.5(\r\023\030\026\r\035\016\016 \023\030\024\035\026\002\017\030\031\033\013\ \017\005 )0.5(\022\024\n)]TJ 0 Tw (-)Tj 0.186 Tw T* (\023\024\027\036\027\021 \020\036\n\024\030\030\024\017\007\026\035\034\027\ \024\005 \021\022\026\027\017 \r\027\031\021\030\036\027\027\036\020\024\ \020\036\n\024\030)Tj 0 Tw (-)Tj 0.114 Tw T* (\030\024\017\007\026\035\034\027\024\020\024 \f\023\035\036\021\036\027\017\ \016, \r\r\024\007\017\035\f\016 \r)Tj /Span<>> BDC ( )Tj EMC (\026\027\026\035\034\027\t\005 \022\026\027\026\035 )Tj 0.019 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\031\f\017\035\017\036\n \027\026)Tj /Span<>> BDC ( )Tj EMC [(\020\030\017\002\024\r\017\007\027\031\033 )0.5(\030\031\004\022\031 \027\036 \002\024\035\036\036 20\203. \200)]TJ /Span<>> BDC ( )Tj EMC (\030\036)Tj 0 Tw (-)Tj 0.136 Tw T* (\032\017\n\036 \030\036\026\035\034\027\024\020\024 \r\030\036\n\036\027\ \017 \027\026\002\035\033\007\026\035\024\f\034 \023\024\f\021\036\023\036\ \027\027\024\036 )Tj 0.217 Tw T* [(\f\027\017\032\036\027\017\036 \017\027\021\030\026\026\027\026\035\034\027\ \024\020\024 )0.5(\007\026\r\035\036\027\017\016 \007\024)]TJ /Span<>> BDC ( )Tj EMC (\f\021\026\002\017\035\034\027\024\005 )Tj 0.18 Tw T* (\024\f\021\026\027\024\r\022\017 \036\020\024 \f\027\017\032\036\027\017\ \016 \r)Tj /Span<>> BDC ( )Tj EMC (\021\036\004\036\027\017\036 30 \f\036\022. \215\030\017\002\024\030 )Tj 0.12 Tw T* (\017\r\035\036\022\026\035\f\016 \f)Tj /Span<>> BDC ( )Tj EMC (\235\017\022\f\026\006\017\036\005 \022\024\027\036\004\027\024\020\024 \ \023\024\022\026\026\021\036\035\016 \007\026\r)Tj 0 Tw (-)Tj 0.159 Tw T* (\035\036\027\017\016 \017)Tj /Span<>> BDC ( )Tj EMC (\r\030\036\n\036\027\017 \220\022\f\023\024\017\006\017\017 \023\030\017\ \002\024\030\026. \200)Tj /Span<>> BDC ( )Tj EMC (\022\024\027\021\030\024\035\034)Tj 0 Tw (-)Tj 0.202 Tw T* (\027\024\005 \020\030\031\023\023\036 \007\035\016 \035\017\022\r\017\007\ \026\006\017\017 \f\023\026\n\026 \200\202\221 \002\t\035\026 \023\030\017\ )Tj 0 Tw (-)Tj 0.447 Tw T* [(\n\036\027\036\027\026 )0.6(\026\022\030\t\021\026\016 )0.5(\207\215\221 )0.5(\023\024)]TJ /Span<>> BDC ( )Tj EMC 12.116 0 Td [(\f\021\026\027\007\026\030\021\027\024\005 )0.6(\n\036\021\024\007\017\022\036. )]TJ 0.275 Tw -12.116 -1.218 Td (\200)Tj /Span<>> BDC ( )Tj EMC (\024\002\036\017\b \020\030\031\023\023\026\b \r\t\023\024\035\027\016\035\ \024\f\034 \017\f\f\036\004\036\027\017\036 \021\030\036\013\017\027\t )Tj 0.08 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\b\017\030\031\030\020\017\004\036\f\022\024\036 \035\036\004\036\027\017\ \036 \020\036\n\024\030\030\024\016 \(\007\036\026\030\021\036\030\017\ \026\006\017\016 )Tj 0.234 Tw T* (\r\027\031\021\030\036\027\027\017\b \020\036\n\024\030\030\024\017\007\026\ \035\034\027\t\b \031\035\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\n\031\022\024\023\036\022\f\017\036\005 )Tj 0.156 Tw 23.244 32.881 Td (\017)Tj /Span<>> BDC ( )Tj EMC (\017\f\f\036\004\036\027\017\036 \027\026\030\031\032\027\t\b \020\036\n\ \024\030\030\024\017\007\026\035\034\027\t\b \031\035\024\r \017\035\017\ )Tj 0 Tw T* (\020\036\n\024\030\030\024\017\007\220\022\021\024\n\017\016\).)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 303.3769 676.1179 Tm [(\033\034\020)21(\223)50(\r\241)46(\024)52(\026)45(\024\232)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf 0 Tc 0 Tw 10 0 0 10 303.3071 651.7618 Tm (\027\t\b\007\006\005 \004\003\002\b\001\003\003 \201\215\007\217\n\003\220\ \005)Tj /T1_0 1 Tf 0.056 Tw T* (\215\030\017 \024\006\036\027\022\036 \002\024\035\036\r\024\020\024 \f\017\ \027\007\030\024\n\026 \r)Tj /Span<>> BDC ( )Tj EMC (\002\035\017\032\026\005\001\036\n \023\024\f\035\036)Tj 0 Tw (-)Tj 0.112 Tw T* (\024\023\036\030\026\006\017\024\027\027\024\n \023\036\030\017\024\007\036\ , \r)Tj /Span<>> BDC ( )Tj EMC (\024\f\027\024\r\027\024\005 \020\030\031\023\023\036 \n\036\007\017\026\ \027\026 )Tj 0.178 Tw 0 -1.218 TD (\f\021\036\023\036\027\017 \r\t\030\026\032\036\027\027\024\f\021\017 \002\ \024\035\017 \027\026)Tj /Span<>> BDC ( )Tj EMC (2 \f\031\021\022\017 \023\024\f\035\036 \024\023\036)Tj 0 Tw (-)Tj 0.064 Tw 0 -1.218 TD (\030\026\006\017\017 \f\024\f\021\026\r\017\035\026 4,5 \(3;6\) \002\026\ \035\035\026, \r)Tj /Span<>> BDC ( )Tj EMC (\022\024\027\021\030\024\035\034\027\024\005)Tj /Span<>> BDC ( )Tj EMC (\227 6 )Tj 0.188 Tw 0 -1.218 TD (\(5;7\) \002\026\035\035\024\r \()Tj /T1_3 1 Tf 0 Tw (\032)Tj /T1_0 1 Tf 0.188 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,0085\). \221\021\026\021\017\f\021\017\004\036\f\022\017 \027\026\004\ \017\n\t\036 )Tj 0.054 Tw T* (\030\026\035\017\004\017\016 \f\024\b\030\026\027\016\035\017\f\034 \r)Tj /Span<>> BDC ( )Tj EMC (\021\036\004\036\027\017\036 \r\f\036\020\024 \f\030\024\022\026 \027\026\ \001\036\020\024 )Tj -0.006 Tw T* (\027\026\002\035\033\007\036\027\017\016, \017)Tj /Span<>> BDC ( )Tj EMC (\027\026 7 \f\031\021\022\017 \n\036\007\017\026\027\026 \017\027\021\036\ \027\f\017\r\027\024\f\021\017 \002\024)Tj 0 Tw (-)Tj -0.03 Tw T* (\035\036\r\024\020\024 \f\017\027\007\030\024\n\026 \r)Tj /Span<>> BDC ( )Tj EMC (\024\f\027\024\r\027\024\005 \020\030\031\023\023\036 \f\024\f\021\026\r\ \017\035\026 2 \(1;3\) )Tj 0.092 Tw 0 -1.218 TD (\002\026\035\035\026, \r)Tj /Span<>> BDC ( )Tj EMC (\022\024\027\021\030\024\035\034\027\024\005)Tj /Span<>> BDC ( )Tj EMC (\227 5 \(4;6\) \002\026\035\035\024\r \()Tj /T1_3 1 Tf 0 Tw (\032)Tj /T1_0 1 Tf 0.092 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,0001\) )Tj 0 Tw 0 -1.218 TD (\(\217\017\f.)Tj /Span<>> BDC ( )Tj EMC (2\).)Tj /T1_2 1 Tf 0 -1.218 TD (\024\235\007\006\t\215\003\007\005\002\240\007\255\b \n\b\200\235\002\240\ \202\005\202\255 \002\b\203\b\007\215\204)Tj /T1_3 1 Tf 0.286 Tw T* [(\255\203\031\021\013\026 \f\205\021\013\203\025\n\021\026\023\022\021\n\202\ \n )0.5(\t\n\t\024\n\002\021\025\002 \024\n\021\205\t\026 \027\021\205\024)]TJ 0 Tw (-)Tj T* (\032\031\021\021\031\202\n \026\021\026\023\022\021\n\202\n \t\f\025\021\ \013\024\031\032\026)Tj /T1_0 1 Tf 0.303 Tw T* (\215\030\017 \007\024\f\021\024\r\036\030\027\024\n \f\027\017\032\036\027\ \017\017 \023\024\022\026\026\021\036\035\036\005 \f\030\036\007\027\036\ \020\024 )Tj 0.105 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC 0.855 0 Td [(\n\026\022\f\017\n\026\035\034\027\024\020\024 )0.6(\007\026\r\035\036\027\017\016 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 11.641 0 Td [(\026\027\026\035\034\027\024\n )0.6(\022\026\027\026\035\036 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 8.26 0 Td (\023\024)Tj 0 Tw (-)Tj 0.004 Tw -20.757 -1.218 Td [(\022\024\036 )0.5(\027\026)]TJ /Span<>> BDC ( )Tj EMC [(7 \f\031\021\022\017 )0.5(\023\024\f\035\036 )0.5(\024\023\036\030\026\006\017\017 )0.5(\031)]TJ /Span<>> BDC ( )Tj EMC [(\023\026\006\017\036\027\021\024\r )0.5(\024\f\027\024\r\027\024\005 )]TJ 0.077 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\022\024\027\021\030\024\035\034\027\024\005 \020\030\031\023\023 \()Tj /T1_3 1 Tf 0 Tw (p)Tj /T1_0 1 Tf 0.077 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,001; )Tj /T1_3 1 Tf 0 Tw (\032)Tj /T1_0 1 Tf 0.077 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,0001, \f\024\024\021\r\036\021)Tj 0 Tw (-)Tj 0.053 Tw T* (\f\021\r\036\027\027\024\), \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \025\037\212 \023\024\022\026\026\021\036\035\017\ \002\t\035\017 \007\024\f\021\024\r\036\030\027\024 )Tj -0.067 Tw T* (\027\017\032\036, \004\036\n \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \207\215\221 \()Tj /T1_3 1 Tf 0 Tw (\032)Tj /T1_0 1 Tf -0.067 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,001\). \203\026)Tj /Span<>> BDC ( )Tj EMC (45 \f\031\021\022\017 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\023\024)Tj 0 Tw (-)Tj -0.051 Tw T* (\r\t\001\036\027\017\017 \f\030\036\007\027\036\020\024 \017)Tj /Span<>> BDC ( )Tj EMC [(\n\026\022\f\017\n\026\035\034\027\024\020\024 )0.5(\r\027\031\021\030\017\026\027\026\035\034\027\024\020\024 )]TJ 0.131 Tw T* (\007\026\r\035\036\027\017\016 \r)Tj /Span<>> BDC ( )Tj EMC (\023\024\022\024\036 \r)Tj /Span<>> BDC ( )Tj EMC (\f\030\026\r\027\036\027\017\017 \f)Tj /Span<>> BDC ( )Tj EMC (7 \007\027\036\n \023\024\f\035\036 \024\023\036)Tj 0 Tw (-)Tj 0.021 Tw T* (\030\026\006\017\017, \r)Tj /Span<>> BDC ( )Tj EMC (\024\f\027\024\r\027\024\005 \020\030\031\023\023\036 \023\024\022\026\026\ \021\036\035\017 \n\026\022\f\017\n\026\035\034\027\024\020\024 )Tj 0.056 Tw T* (\007\026\r\035\036\027\017\016 \002\t\035\017 \007\024\f\021\024\r\036\030\ \027\024 \027\017\032\036, \004\036\n \r)Tj /Span<>> BDC ( )Tj EMC (\022\024\027\021\030\024\035\034\027\024\005 )Tj 0 Tw T* (\()Tj /T1_3 1 Tf (\032)Tj /T1_0 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,049\) \(\217\017\f.)Tj /Span<>> BDC ( )Tj EMC (3,4\).)Tj 0.119 Tw T* (\215\030\017 \024\006\036\027\022\036 \220\235\235\036\022\021\017\r\027\ \024\f\021\017 \f\030\026\r\027\017\r\026\036\n\t\b \027\026\n\017 \n\036\ )Tj 0 Tw (-)Tj 0.009 Tw T* (\021\024\007\017\022 \035\017\022\r\017\007\026\006\017\017 \f\023\026\n\ \026 \027\026)Tj /Span<>> BDC ( )Tj EMC (7 \f\031\021\022\017 \023\024\f\035\036 \024\023\036\030\026\021\017\r)Tj 0 Tw (-)Tj 0.239 Tw T* (\027\024\020\024 \r\n\036\001\026\021\036\035\034\f\021\r\026, \r)Tj /Span<>> BDC ( )Tj EMC (\022\024\027\021\030\024\035\034\027\024\005 \020\030\031\023\023\036 \f\ \021\026\021\017\f)Tj 0 Tw (-)Tj 0.126 Tw T* (\021\017\004\036\f\022\017 \004\026\013\036 \027\026\002\035\033\007\026\ \035\024\f\034 \f\024\b\030\026\027\036\027\017\036 \f\023\026\n\026 \200\ \202\221: )Tj 0.008 Tw T* (\031)Tj /Span<>> BDC ( )Tj EMC 0.686 0 Td [(3/48 )0.5(\(6,25%\) \023\026\006\017\036\027\021\024\r )0.5(\024\f\027\024\r\027\024\005 )0.5(\020\030\031\023\023\t )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC [(\031 )0.5(12/46 )]TJ 0 Tw -0.686 -1.218 Td (\(26,1%\) \()Tj /T1_3 1 Tf (\032)Tj /T1_0 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,01\))Tj /Span<>> BDC ( )Tj EMC (\227 \022\024\027\021\030\024\035\034\027\024\005.)Tj 0.214 Tw T* (\221\023\026\n \200\202\221 \027\026)Tj /Span<>> BDC ( )Tj EMC (45 \f\031\021\022\017 \023\024\f\035\036 \024\023\036\030\026\006\017\017\ , \024\023\030\036\007\036\035\016)Tj 0 Tw (-)Tj 0.205 Tw T* [(\033\013\017\005\f\016 )0.6(\023\024)]TJ /Span<>> BDC ( )Tj EMC 5.173 0 Td [(\023\024\r\t\001\036\027\017\033 )0.6(\b\024\021\016 )0.5(\002\t )0.5(\024\007\027\024\020\024 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 13.858 0 Td (\r\t\001\036\024)Tj 0 Tw (-)Tj 0.271 Tw -19.031 -1.218 Td [(\023\017\f\026\027\027\t\b )0.6(\023\024\022\026\026\021\036\035\036\005, )0.5(\f\024\b\030\026\027\016\035\f\016 )0.6(\031)]TJ /Span<>> BDC ( )Tj EMC 16.48 0 Td [(5/48 )0.5(\(10,9%\) )]TJ 0.005 Tw -16.48 -1.218 Td (\023\026\006\017\036\027\021\024\r \210\206 \017)Tj /Span<>> BDC ( )Tj EMC (\031 10/46 \(21,8%\))Tj /Span<>> BDC ( )Tj EMC (\227 \025\206, \030\036\031\035\034\021\026\021\t \f\024)Tj 0 Tw (-)Tj T* (\023\024\f\021\026\r\017\n\t \()Tj /T1_3 1 Tf (\032)Tj /T1_0 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,27\) \(\230\026\002\035.)Tj /Span<>> BDC ( )Tj EMC (4\).)Tj 0.019 Tw T* (\221\027\017\032\036\027\017\036 \021\024\027\031\f\026 \200\202\221 \031\ )Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \004\036\030\036 45 \f\031\021\024\022\ \023\024)Tj 0 Tw (-)Tj 0.115 Tw T* (\f\035\036 \024\023\036\030\026\006\017\017, \b\026\030\026\022\021\036\030\ \017\031\033\013\036\036\f\016 \f\027\017\032\036\027\017\036\n \f\030\036\ \007)Tj 0 Tw (-)Tj 0.079 Tw T* (\027\036\020\024 \007\026\r\035\036\027\017\016 \r)Tj /Span<>> BDC ( )Tj EMC (\026\027\026\035\034\027\024\n \022\026\027\026\035\036 \r)Tj /Span<>> BDC ( )Tj EMC (\023\024\022\024\036, \024\021\n\036\004\036\027\024 )Tj -0.019 Tw T* (\031)Tj /Span<>> BDC ( )Tj EMC (20/48 \(41,7%\) \023\026\006\017\036\027\021\024\r \210\206 \017)Tj /Span<>> BDC ( )Tj EMC (\031 12/46 \(26,1%\))Tj /Span<>> BDC ( )Tj EMC (\227 \025\206 )Tj 0 Tw 0 -1.218 TD (\()Tj /T1_3 1 Tf (\032)Tj /T1_0 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,25\) \(\230\026\002\035.)Tj /Span<>> BDC ( )Tj EMC (4\).)Tj /T1_3 1 Tf 0.14 Tw 0 -1.218 TD (\255\203\031\021\013\026 \t\n\013\032\026\024\025\024\031\023\022\021\n\017\ \f\205\021\013\203\025\025 \021\026\032\205\204\021\n\202\n \026\021\026\ \023\022)Tj 0 Tw (-)Tj 0 -1.218 TD (\021\n\202\n \t\f\025\021\013\024\031\032\026.)Tj /T1_0 1 Tf 0.303 Tw 0 -1.218 TD (\215\030\017 \007\024\f\021\024\r\036\030\027\024\n \f\027\017\032\036\027\ \017\017 \023\024\022\026\026\021\036\035\036\005 \f\030\036\007\027\036\ \020\024 )Tj 0.073 Tw 0 -1.218 TD (\017)Tj /Span<>> BDC ( )Tj EMC 0.823 0 Td [(\n\026\022\f\017\n\026\035\034\027\024\020\024 )0.6(\r\027\031\021\030\017\026\027\026\035\034\027\024\020\024 )0.6(\007\026\r\035\036\027\017\016 )0.5(\023\030\017)]TJ /Span<>> BDC ( )Tj EMC 19.961 0 Td (\r\024)Tj 0 Tw (-)Tj 0.136 Tw -20.784 -1.218 Td (\035\036\r\024\n \f\024\022\030\026\013\036\027\017\017 \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\026\b \027\026)Tj /Span<>> BDC ( )Tj EMC (7 \f\031\021\022\017 \023\024\f\035\036 \024\023\036)Tj 0 Tw (-)Tj 0.259 Tw 0 -1.218 TD [(\030\026\006\017\017 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 3.966 0 Td [(\f\030\026\r\027\036\027\017\017 )0.6(\f)]TJ /Span<>> BDC ( )Tj EMC 5.821 0 Td [(\007\024\024\023\036\030\026\006\017\024\027\027\t\n )0.6(\024\002\f\035\036\007\024\r\026)]TJ 0 Tw (-)Tj 0.307 Tw -9.787 -1.218 Td (\027\017\036\n \()Tj /T1_3 1 Tf 0 Tw (\032)Tj /T1_0 1 Tf 0.307 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,0001\), \r)Tj /Span<>> BDC ( )Tj EMC (\024\f\027\024\r\027\024\005 \020\030\031\023\023\036 \023\026\030\026\n\ \036\021\030\t )Tj ET q 70.866 122.57 221.102 236.08 re W n q /GS0 gs 221.1023475 0 0 236.2266115 70.8661198 122.4237146 cm /Im1 Do Q Q BT 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf -0.017 Tw 9 0 0 9 70.8661 111.7701 Tm (\022\t\217\210\b\002\220 2.)Tj 0 0 0 1 k /GS1 gs /T1_3 1 Tf ( \215\021\024\031\021\t\025\027\021\n\t\024\022 \005\n\023\031\027\n\202\ \n \t\025\021\030\032\n\003\026 \027)Tj /Span<>> BDC ( )Tj EMC (\t\032\026\027\021\025\027\026)Tj 0 Tw (-)Tj 0 -1.2 TD (\031\003\020\004 \202\032\205\033\033\026\004 \027)Tj /Span<>> BDC ( )Tj EMC (\024\031\006\031\021\025\031 7 \030\021\031\017 \033\n\t\023\031 \n\033\031\ \032\026\203\025\025)Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 0.087 Tw T* [(F)-16(igure 2)16(.)]TJ 0 0 0 1 k /GS1 gs /T1_3 1 Tf [( Intensity of pain syndrome within 7 d)26(ays af)-46(ter sur)]TJ 0 Tw 24.271 0 Td (-)Tj -0.012 Tc 0.012 Tw -24.271 -1.2 Td [(ge)-12(r)-55(y)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_5 1 Tf 0 Tc 0 Tw 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\033\030\031\030\213\b)-20.9(\035\231\213\233\t \021\032)50(\b)42(\032\231\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj -51.938 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 23, \023\0221)69(, 202)69(4)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 23, \023\0221)69(, 202)69(4)]TJ /T1_6 1 Tf 25 0 0 25 28.2026 56.0378 Tm (46)Tj ET endstream endobj 2124 0 obj <>stream AdobedC     '$''''$25552;;;;;;;;;;   7M!AQ"126at#3BRq $%&'()*45789:CDEFGHIJSTUVWXYZbcdefghijrsuvwxyz?UU#Z~XlAyGĢwF>Wf 75hѼG|*}MZZ\t[Q-;x[J yˮi˪-ֽ}vo!.,]*I IdLBBQaXY\qQؑDxfNp3/4î I 1p% +Y JA*Q6 $闟QDO"48@6&;yvÉi2B.l.MŮᢷwF>Wf 75hѼEn6iu%,]+I Id(Upfq.&v(uT ɝfA;OLKx'нWLKx'нGVp"b57,RHlZ[߫n2|t a.7(q*6E7JRvv"Ҩv8P{^s=slu=S}lB6;HHRV䤳lHBP$\hw n= )C2`S1P[ʅ Yq!gM^jnVW3jf[>Kഒ3 UL TYs(S M2^nVRMF?Tb\4{s Ѣ$&T>vjbyLmA%C0#*U1,AtBq]1,AtBqbPʕLg}K2SH9qPU=tz2{r2Mas[=In&mg|MK2+gkp۵:Q̨E  HБ׸C]O w`Y*ީGMjrȜ,mP$!KR8-ϿT}}Ѱce6t͇7a*c1o.\bO`j2 .4k juA$!z-h]Ŏ_V/ bd%K"-}9Slo:hZjBo1kzesBv9ұ3 :ܫr%:2[S;S\ZFƋFcKp6Jb1zeHqYv$ 8j\z ͱ F r"&U{<9VKafҠ ]`T;qnNwQt?P;6R T6:"ߥqgFOk7"JiWK@e,:U^|7!C]O Gn8ִxhӣ0{hZ 6m!Sĝǩ5j]U8jb|Բ=Ed3jT[oČkApM2ljr}ԬYZn:lvs(RFvVP$hۉޗŞG?67"3yR˭)7'(81nJT\zh}PL5t5,ʵC X'G1ȈU!{0L]S-KPKnI'@{;G+ e?cn|G^{+|{#!j})QCJ櫤 sD:mHH)IDARވ̫X# V*)bo`eyR T2T{AUXP6~%QJySnc$L5nHa3nLU*[f[#3#R_ČꈛqQKqS7̍C:l .2J32h"а)ajÅjnb2E 9`u]A ʬdɽ{ igWEt7s)!)S'@`}v0o~=?m:B^ :PijIiYR,.vb*Un2UBj"`L+Pu>^ m75[R bol~I7KrV*NSٵ*̛;plb1k=O%k?}G3 SɯnR=. 1:ԷuS|^bt*tNC|֣Rb)HotFr(܅KkSYrVmڳuZiѢ,KZ5ORfB5\KURENņ }Nrﰩwˊ.%6Ta6ZRRԩ7l2@AF:8#=(ˬ"Urf'>}Tc)WXܴp?.Sv djef|c?1w")n[Y[Yp@UC*U3?MK2fQjL26y]p /qPU ')?Z0 vx[6K]*\bI:Nq[S2l[Sd[uPsKL;fgSݞ .:\.Rmbl-,ٕrL,(JeR wW܁A[l)WIZI)];0ܮ au_ȤKKj/6P1Д?$MdA# ЙϧS)ͳ-ҡPj 1)U @ qI"'f0쓲 Q!״%&PV2}H qe.7gKs w]u9in!fj1H8֔6,I101^06fzd WHkqj Jr '(ˢj",)t1|m-hi*:BR/CMO0$YpÚd\ѣ1N+F7"]RiuSm ,|83)Y3+VVwSokj}Ocj&XafQ/,Yi`! H슀Ui#r:NR9RIpq#>x1AS+mTZ C]NLM.Umb6ʭ$#omԵ.9~kUJKU:C#V F_^ҘIa)u J֭E2..-|׌2cL0t)daҦKܨE4_n:mKh#c 料3UAs) -D xヰ̞zAt/,%XĪQkw*}P$6$I$}`J)-kSQ~Yx&d[DUU/,ݳA<_}hnF}:ɌWɬa7-71(%e(Umᒔbnu]c8fQ(ԣnRf30tFpf6iץڢ{ZHsTWWIU@isrͼHIX1UXUٝԅYtq#M {&>{]6|'ߙxZ2,/)yq(^BVǰF: faN U:[7WܒĶއh64i{q3aQݢ^s^}O[+eэW瘪WRKSs/:k1U&)J&mY`8\ =0'*<󏴵%)ld7qG Qp©2Z"dŹ|^ FzzzJv"tWM+m,$qfhW*2 %KhKt]V92B02?Um֘m!N)*J@P""8UqnIT^~bUi%KZօ%)HlT(5KIr"VT))6V uQT:J["mL2^ )6JIB5\k׶wnnN D No^JePo1$95LK.kjn2A;K2߭u]SLٟ [.D@w%Skfgm6Toh% %KZmWS#vHSwOH5mg.:\/k _E@U=tz2{r2xj%eQ[l<,Nb]2Lk3>71i3=R ljJ84!.Mr-8T1V%Hf< -Y[· Sr7c5F.d:M`i1c#[T͢L ?%|e[k4t J۲yorc*9a;+Uiy;=2ܲ%TQ6_Bi)J)DfI'I$\)Ӕ m)X@PQp.ʲ#un4-fPm'SJ[_u5$e%-`6 iq-Q%e \ã3%O m1u2S5ZV[@TJ\ʶ,p!vS$$ËՒC͔@USXד.2y5U̷bm{BlTTUuaF^(VOLZqm:Rwn2^;_-^ch;_-^chn@[HYiʤX7ڌpL[d4@ZJI҉JLjl0[ Nj M4뛇̛jfbyN0dc5|wnʾp5x ܶr]!*HFWkf,pf&?7Y3rγ69w5MƲ+T )bYmJ*)lI$:6QJ֪.jml ( 8 Sqt2'mXRH˧2MK ⧦rtӧ&.^mťIIqU%h؋NԤe&قRbWNH 6_IaмJԵYgb.b~SSO_x4fuv 8WҰxs^jZRmK>[em'⢠UU endstream endobj 2125 0 obj <>stream Adobed     '$''''$25552;;;;;;;;;;   ####''',,,   ####''',,,   ####''',,,""   o!1AQ"45ast26RTqr#$3%BSbc &'()*789:CDEFGHIJUVWXYZdefghijuvwxyz  q!1AQ"2a4qrBC#3s 5RSTb $%&'()*6789:DEFGHIJUVWXYZcdefghijtuvwxyz?袊DEWv"""?~f Ćml32RV`INrW^XœdMFSΥ-HH;n@R6r!*"Z6ITU/jx.h& kMNpáF:. M՝XVik>3!e5EQeqQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEд袊DEQL숈=P%"\8Lvg0'* <ςؾmyqvJRAy֩)+"٢RזPS X4ٰ8AүtgM^:z]:6WvR)2L2. qހu!H\RN ͂+$X2E&l> Z#~nMMCԣ\Ԥ1\%T. 1Mg5^IV4?n?'<L{B}J'gSIEV҄X:++Ҿ$U8.t+$cQo*.11 (ПRt?Ɲ;|Hq5x?xhO]Q -;|Hq4+E_Ï|CǴ'ԣ<lB}Jo+E_ÏN_*whEgequHH!95<l{B}J7+u#֨P^Ld6-};|Hq5x?xhO]QfӺWĊNҾ$U8Ћ<l{B}J!ccQ&=>wQD"ӧt?ƴ"K쩤iYiBs kox?E +t#xxUf>.W*N_+~WE&=>!ccWuY"ӧt?ƴ"ПR11 +$t?Ɲ;|Hq5x?61C+ӥ Z횓Ҿ$U8[:]jki{| 8Y .11 (ПRt?Ɲ;|Hq5x?xhO]Q -;|Hq4+E_Ï|CǴ'ԭMlۏ8c4Ҡ%)i:(o+E_Ï񩿢:[MTEGɗxYˣ<l{B}J>썟[W u8Jl7;LP$n( _.ƵZֱ-f _=Ipp Ο;sSglwԃF;hs@y""ɹ.(Ώ,<"+Ώ,<"+(czb7:)mn iJҥ$7s\8shg~7m6e&2,Fc5:<("":<3h""/3:<""":<3h""/3:<""":<3h""/3:<""":<3h""/3:<""":<3h""/3:<""":<3h""/3:<""":<3k""":<3h""/3:<""":<3h""/3:<""":<3h""(#ħ.;u!1R.&k*RRhHNEWuE٠˺i4Rs ilYBUƏ鞩W@ԲzYu(H.1N=qVс*WM x1eũ|J -2 Xy4z|~?MejN]i /zZKfͮ!ϵ t-tGUkd1\(k !pf@[n$h  e@\7#F+3!%I(VJT/˨5GIs̸^|BZ~"2ouInҴsש@8quQEa1ֈ﨟:uSjcCzh~=OUEVQy\8?Y}I:wW_{NMSwdg"XY+(""("""pcMWupǟߟ8TdxVNηwQEPXDDQEDDDQEDDDQEDDDQEDDDQEDDDQEDDDQEDDDQEDDDQEDDDQEDDDQEDDDQEDDDQEDDDQEDDDQEDDDQEDDDQEDDDQEDDE}p(#WmE٠𕾯(zgZء鞩h@մc1bK Fx<\!^dYVw5*(!E}k fZХ!=Jt59-{AҏCn~p)t -0[A3 ֩Yͦ&TJ i \)cCj? JHOQ{4fP+B۷Teِq4jWYQ5*41.2K8I8+ѦҚV1S)19x esEVQ1ֈ﨟:uRjcCzh~=OUEVQy\8?Y}I:wW_{NY1vMr,袊‚".bTpW& M Ros]*Ȝaۯj{#GI5*gL0'X;`G9Mý??q5]Ň{~~j+Y;:]QEQExMpL"C\]m)H_JSm\*]MRtx~YXY]QEekXDEpr2U+jK U}*;?WP IXQZQEQEQ\ؓ#A~L`--DhA䮚Ż3^*%:Bj0 9f+F[0˝HIV[6Fv}Qw""(,"""("""("""("""("""("""("""("""("".#WmqGA*j.}C=RзLKBִYÛf [ˌ]."H]ւݮln^Jf5? KӃ ʛŒӪ-( @X9/0]Q*hvQ)Ui1奬xHGuKH}i<-}Nnm1ZKhBS`V]ljw(ڋٙn"|YQJCijA`4)Yw >>]2ꗗ.5Y|ř݂ftniXֱ\^DD`QRӈ2q ^"(!py3] JF"y!P(j%e8TF,as2\h:uQjq2b(70iuhXTpEI|D]Z}7լSisB4 'OUSsZ9,A[(I1*KLByﮜ( AA"'(pe'땺V! ROTHIZA;/\&%x$6 @P* ^7H#lk\i8MZҋ%esܲohZp̔ts𸛀j?'I$,\CKv% )pd5!(VUltΦA-p܃m8*&"DtE&1AA#0LyX#R.4AuoꖅoIRTii"%Q״T|YǔPvByuΟq]JqW?FC-)dBHIAPڇ% -6a'{-hYU]yYSBШ^kM:`7W 01j؂#`xs3x̢}vWLg$-dVbG!#ZAiQtAhf I $*Eiht&Aʮ cm wkLJ5aCaҖS0W%iA6SJ(DUޗ[Fg 2X:hK!'6ECDj.,c5D=IXDD]®͵NۮWf'zm֥nIDD]QEekDD^T~9k ]3R5_WN7U:mB+QEQQ́mx_Ӓ*FrElū?\Ճ\L[s;Q˴R;6"-ݮp+mj}uq\"/ TͧUVT+Uu qY(mWUL6yWUL;J*.#{̈("" F}oۭ=Oo8C""+Z"""("""W&V}jr_5\s""ՅdK zDW]ra]EujqA""("". Rm#WmqGA*j.]UƏ鞩W[bzдjk fb&?=cuM /y*X| Y~CM*IPNka{T`!^`(g?KWtۨ ,Ձp1]=F"t0pC5 RyB4[[$e KSをWEsaӛ9R!VkC =/1H; ݚYk- ~;C*s^/,.a%ͱ@$NؾšQEQ1ֈ﨟:uk#%ƇD]XzGs˵!sU%bJB l%m kԒ5&~ \ Z { 꽥hU(QQi@$q{`l+U:5-{Nnnٹ{){n1fEVVT).Unv=NKy$$ D{_*hu=ڎƙk(BRKt2hnBѴcדS8!l)#oV[7tFqY`G\XȎ괚sm HP󎵝i}sg# ]lgq & '3XUy%= TM.!jv8|7m5Ҿ su[' + ~c1)F%O>$ 5`$$ht67OL 8L8ʱ@ӕeWj;rSsp *)J'RH5,{LXbl!a}u#QY߰O[({zfprDDR4QEkDDDQEDDDV}jr_5W:+;ٞ»3΁QEE~«Vo]fVء鞩h[bzѴP%F,@fcr!vS$*HvLL1ݝl++K)YqE@Xt9 zTz1i:&P+I(1O or.Ahuk4k #[IÌ6jc8*c"3mPdшYQ^fq~nZ",10`.8|M6^k.ǩI#L_b`G5[Ř|+5zx7ΗD M*:pxʑ,7B 3H|+>e;  ĄovVwi8m Bw%!#VUbF}dE\m7\CG0NqojiV$TM ীIݷ|&yۡm0}Cg`O,.ʹbw0r IJ,o'  E(ۧ?rNJJp` t_L ͹\)6pA~ #15wQAu\KdI'y2qq.9(7n25DZOz?n6Ԧ~.4jP=v{u˱61QSzWz>ee5;z?d`JWf'zmw%pmw6냵u(qԔDE^WVVDD===߱iPרi:1i29ǗMwN%_RCK:DYXVkpAQ^_DD^EyDDD\اceUW*=ZXpYO*o|Jo1TtGO͋v.gzUniamj+N+عAU;FУgdpG]>Vii;zh7SKl&Ǟƪ yUj 9;okUvzQ\@f'o-<E"&aS0V_:T,-4T>yWULZӞUg<ki;@BKmG|,". ;jB>D) 2[zXY+o۩11אGާo>pf.FRTyS""(""+L{/Ze~[qΈVȝDW]ra]EujqA""("".#WmqGA*j.}C=RзLKBҴkp]ˎe.婤2Cm yKr91ʐ)q9ˠcZrT6Bw7:h֧Y*s*u)8`aZ\`%]h 4MujTѝMa9 3b8D"e! hYf%DkwRǻ!PpNaZZ}TNgBu1]cܺ˛]!^}3EϪi.n 88Gi.#( 4QҪqʺE [ K)4> CB,\%($oړ0Kv/.'T*:u%6-hn30NB%JZV2-(*)I7:F$@V]CIfԪf)Q qu7+fI3]k&0 Zjjc s ]6/qņ Top&xT24ZTlWF1ֈ︟qfCb,ζcdRH6w84{eql- n"r~zxz$7|5"[SwfeĐ59ZC%Lk,r(z̬ Wt^*QS`s:6#[1l2rL4ML9". £p^+ˡPMG>\8?Y}I:|[&sLZ-0]zchJn Ks1""(,ۜs8>YV$եMa(hLn6!WUJ$Eڌ9aY!܉_wëa@lZ#+O *[cpVf6 TxLΰP,-kå*XM+7!$B&mY$&7H?Hi)Ş$*%/87Pa^X JJ~OMW]\Al F@w4]1)TcZ>zG2HØ xV9u*"*iXDQs> UEh1l0γu)^#hޛfg-n1e!-Y5τ@űLjd6 w=fӍV+)VoJRxXDfa=!s݋"G-LNn w VX;FaJ۔"no*A `_WjziS|8Gw3H5 @ 氶N -l[sP U}4e0 HRUb. $.EH Éq̴Q;H-$“:BBVpYV^P\+M×SL3r]Qac}S'1Y.7)o3!̢/#@FP:HO1ҧZ 1̘"lHvmJe4TEjm.«*26AԤW>`PK0J1:=mļt.GEuS"eȂA] -w{,I$5`n@`627oYv%`lu8>^+J"%}3*.͈oRMl=J L|H^rR2!`uUu9Qd7ɛX״9{3{`#mA"`Ĉ,, 9JZ#A9*K`N$9yPx)$H{M®CEi[jκ>i+R!sz +Tk^HV,I9 d ظnLLZ7wOvÞJRmBEŹ@5!s멝͏r3 ӣUujMNYfTtBwi$3 9wyQRQx7p3.CNA(Z|jMpZMûrXhHYMdgkv:npxI.2фMiE9tud79@Rju57s-;r?Dh3Fn.$nQѪ;yYiS~"V$f& pNa5X-G-ugk3otۮV^̓ג< XNR#tfNZ!MIW~붢]oIiPѤ؛P׎7IUE(zgZӴKX0ZLb-G~@d8RJH\@443Z MkvMkԦZֺ/eR:w\YiEQXYDD\XZ#~nphy5&䱵Xz_uV*K=ut@{w3U"/BjzVa'Uy?ޅw}'A\qB_n?w:uBtTGa!w*B4˟_=r;#΢;#΢G~al{Zin{{7IA+?M5= '{ji~gYZ@XW#:+|t>GEu]|n(6F޲Qq^Ea.&*&?uZxceUW*=vīFsGFDJ;E;َߌO]s9_3?lxWs>Rg뙝͟r3Ժ=USROwx xwWzjjdJ\~r:!g\"+dz? tTspZkjejճ_J7 5@37a É".=Mm{HW3w[UڹSr""Y?Uv~«ֱ+}_lPT-}C=RЀԴ/bʟ=$v+tʒU8P5)>i`5|CrChCCV@BT;r[(0]ѴM4VW+eƛ<1q6 *h i,>ֺ_KA u+yrpe)m^Jx <㞻+ LPru'&h%TCM)vKFnv*ߦiU4"V1t `h@"("":ukDwOuddXz_tJ;I-?u!I l6E4r(oԟ>;.ԍY^JTX !,li%$;ݐ̙"p~ؓu$rl =ɼEW}QEDUy%= TM.!jv8|7m5Ҿ su[' cMWmqaǟߟ鳊ANηadxWuy^EDQA@Z2HZ-H` Zp àq&8B [XTlT޲\ tEXV*83fA$FT 6YB,"ܿ8yvoLR@Pt ƫGB[ԛ#p]tPbs1-2hou鱎1hRvuc|D{1]΄;QHGmEHGmul]Ll)6Gw6}˔RSSTVU^}HYD)lw9Y+ %axjo$uc6.!2t >ퟻMMxwkئZ:'Օz S}η".?qi盛>0Vjo + + Uۭ(Gf盩UY^v;(@wFu':/^)A:UcɋWKˎxQt <Taa`oU†:*;ɧQ6'5;e1hyqJDLR, z +\qm)r;FĊ6zZZx`:>. =w@8&$7~ULjN~vj7's{u!Sz`}[޺"/Mq`e'HAQmɩ0/< I6Z԰tQl =Y+ Ne!^j1h|Z‚"*iu\@ jv8|m5F-IqY! ͡P;MlvaL-J@@I:+UzևUDapb3m&;Yܰvug tT!*՞!JaĤ\ UudgC-C;v Vd|55F1q`k6< IuE'mx곦3 77"FSB siRH˾ۯ@>խUy`FL77R]f+ N;SQ:kA^>.DDR41k’ҝinp)HF[ z%j{sIs.9DSc1KCbv^fXUD8 Jۥ1̬@OqPEa.kAk^v.!e iZEL+fTg!q]JKlb|v;!"' ڨisCDCˆ=v;_6RaԾhkAٜίuj{Jz=-%_Rʦnos8&F@N0XR&1#澕#Q8V0Xw1JCe*̥(ɩN3tZz~%ems,x 4.+}{iVӒpؓS9n֨->8PmgU'6jEaeKfĶ`b1QEŌu;'뾸1G}Dպmƴց Gc{2sV*quI$K]3R& Tp^YZ-k$13.5 WEpJPtW]/4d YknǟPU:eb\VF޲qm $7nz+k;/!QvvGxE9"SjDDRɋv.gzUu&-عAU[){qyk Zp+mg]Ec(Kp_釪B.;qQ>ΈU_m3oĶ%m(\UiO5l]udi6n]aLisA9 E Z21=V|+>3#[ 22Un?5k Ҫ\C1Q‰)ju[Cuki8^1en!`Ei O{jK#>@`o۩;}P>ͼpH@҇ʁ<6 &8L M6Zo4h6]媫Υw]Se^Pc^`-a#M.rA8Iω@9?BxUH Iy Yxq"$h-a uɪV1؋i$Hw{ܚٗku>M=E' A[*Iip2X^!LV}jr_5KWx(a]Eu(ڹpDfz"T.k5:lDD\.ve{HUr IJ+r~ ڧ*R2$$UMKn33[4WhIZE 9gbQU qanSZNk?efU\Q)7G Al}C=RзLKBгѝJYmn*Tm३sxY*J;-Rځ-+֋EpL6[N Ĕs,EBD0VUq0n$3$mP2ss{CTj=nophtYڞS‹Ԯd69.+B#CmRڎ:״k*Afא lH߁I"=J\`P}뾹Bc(nI$7dtUK$`6 `wT/IWUu\I Ѹ4lkD7QZQ6+o SIZKސn7ehzK(7Iu iR&# 66aZ1G}D-_qDE!\bwW]rb݋ޯZ]ٷn}?iw]=rĺ z*?3a9OP舋 oK\=s9Fb$k 1n]u5Cug@]E]looDͤJH%ۋ(wIX'f!Nկqyoo~QWvTݮuTv7m?ԍGc}f~>th{zfp$DE!DKiV %E "*^RN"Oq1OVzMϴy3;$D;cwÓVRR,4_/r{}4ՇTe:*F8Ԇw)G3>*+/^KV}jr_5ou:""-XWc"w=]J|»qA($,u5zlDEu]#9KFV芯P +'s0LdPUn W+`Un}!$bm=ru5\GjjYނ?EU\Q)7G > gnꖅ(zgZѴE֗t8U-Qn JҡwSKɏ%;A*VWB[ :% ZTb,4< >;y|2v:J(:IfnᚌN-^'=<8<@sfF P ݡqhQ=WX>T^>YQYDDEcOјSzDDEcOјSzDDE5;p,A̴ i]Z$S㵡"jXdF7xd 崕EcOјSzDDX>T^>YQDDD\Ӌᶔ+ BrܒPk–a/0 m!H^LHJ-myj>iQ"򈈼|ZQ>-Ԟwˣ]®͵Nۨn[hqԔDEۘSzf>T^eEekDDX>T^>YQDDDX>T^>YQDDDX>T^>YQDDDX>T^p6쎤^o$vFrEl_qDEݘSzˊ3=j7Wn+\r-ͼ舋lu <÷[3*}/V}uq\",s*}/V;u'ݺKp_釪txu=CN]Έ*}/V6$c2x'VT))9AZ08l[)T4^ڍͧj--N;Z'tY;d:ZIr)ʟKծ$E< knh]7l[tέY0Jw"fǔBֲ|Zx}I| ۩*;}C6X䈈*}/V㶥nl +Kۍi#!N7X)3;H>n#rXX~[cOO馫h34`|Mo4in N|cZUy+ ʟKխ2xIn+L{/0uYi”|LԞgpqϸ#v dNg+NB{BnQ7:y_V6xVڬ$8OyAbF,[fL6roSvL ؤv-(H&Z0奈 B-<&汽dpN"ăaS4 n9^&Ag_IѪs*{mdTEcqm@LnV\浤'dljca98@KѺ9ßS- G\{YZ*PIWnM*>_,2[5t|/k>nGZ}C=RЀҴk}7"/Ia%[ھQLu,⒆?&;isN%l l|mk\y.CMOINZҴ}JN,쁖Il]·=1tsY5JCGxc쫈6\4xNim YHExjp;~j\Ϸi﬜)}RVNη"Wզ_Zܗ4ou:""Յv2'{3ԭή\+;ٞxRdylDDU:]V芯~$<c7Wh߽uz-ģw3ʞw:NCΠsZ#vRo]}p.P𕺯(zgZء鞩h@Ӵ, kqkai epi{]Z 3Rv<^.SC\yC 4S IRM7{NGy^`z-]#VeZ.)b a}1D. ~:ǡښNLm!Z؛DkF؄ͅKnv̶ q$2WԃZ;xDh!+JQ̐Hz2HK^*D|\6+q~Y]Q?Dm7MQEQ1ֈ﨟:uRjcCzh~=OUEVQQEQEQEQEQEQExk]k]ƸUٶޛue7袊ֈ(((5Ȝ.&A-zbr5׷/5vQYpAd,"h+TaQNv,܋m+u Qd kiZlY)QE4DEsH}/3JS]TVC-$6=dlXEx"Ʋ6 7$zf($I$rsI2V\`F G 'Pt"hZCH "Vf{BB'@W#+(fRm۷%t&VI.2LU@!"+[̡˃2IJpt#JE9Ee1⣃i57$ 5kGI9tY$'5D U\pjs*ls}KhJ, pl6Blg/ ܶ{)bq1Oi3U.3#vVo]}pZoꖅ(zgZԴ#^t4ZTjWiZUm-0$/<$X $kԅraL`LN 9x ?޺'3(2\RE<a1j Ya $%cNҫT#GqfLz6*db(ڤ.B\CwBԩ Fp<^\s-{ߵAs[X~٥G,p{]} CSJ`|3nVSZ#~n;+i!KbI9A<3vSm%% #JTV*MMqhQ=WVY-oKZG/4U݄8$L $ I=uyE<>(Qu"",na]|(*+x}_0"""ʊyE<>򈈈Qu"",na]|(\*]Ms5x܀f:YSE\!rvl'4YXYؤhna]|++Z",na]|(*+x}_0"""ʊyE<>򈈈Qu"",na]|(*+x}_0"""ʊyE<>򈈈Qu"",na]|(*+x}_0"""ʊyE<>򈈈Qu"",na]|(*Ps"".';4yn9Ʊ%-6XK+hB_.CyyY;:Tʝl3K+ 6^V~«pHV%8m-/,{,-eXܥ⤪k-}C=RЭ"jpjN&AŐ:G-ʢմS1ő)fZ>PByRZ&R%&؛L(ŷagJdYe.P:Gy^`V֥OYGJ-asD0Qdъ` _MähRION {lXӪR11rSJc+CkA\ZX!DTIkȄcY -! ,@'Mg!\N~ץP Sa41lEL&Y:1%$w-5̌7nZX!OEQZDtʚ347]R2{0opفUQqchy cQ?O7]&mV4?n?'ƇD]QEeEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQ~«Vo]fVء鞩h[bzִaKXrWzc&C l6R[GIIQlZdt-M(VE| 5,| {ƱJf %[WӷP3C]yEmЮO5+4kP7  2WК] 隽ЛTEUK`K@x`6"ƁHͩשVt5uA ߩxmd:ˇ4FZzR㇓\+JY}G9&j`.$֊((DwO}pchy5cjqhQ=WV4?n?'袊+((((((((((((((((((((((((#Vo]}p4LKBW=3-״\B\mMZJMX؍EEf0[q/-*)T$s\j* $J`k[x6+Oz]'5ۣ1p-st-88FAsQi%-4I%D $(ݥiUt4:gbsZIۅ4v҈+mQm'e":[|6륖)F[*U{[Jf".NW殎粘gIe3A 8p cQ?O7]u;'뾤ܖ6_ucCz((((((((((((((((((((((((?efU\Q+7G ڋA+}_lPT-}C=RЀд袊DEQDDD\s*^o8d{<JTzk"JQ8e\q7J]ZeRR/'X#[N)V[A>kEutI4^YPуV:E:;WNj-I?:츥4T\n座_̻oEEqTc0sZM=Z'?C$X7`:C{⬋&7戾wL\jC*dɎөV?jkrSpl39 R$/k8 +_jo:U6<9=WfG)Q\4"JAuz5Mqs 94E˾&7戾w# JWpRiRIJA"~}S_Rh4*R ak״kAqZLo}ɍ/]}vLE!XǢ3W=ᚿWEœD_l8WJ4jT|[I;IJ8ui ̶RIlɍ/]}gNoRs.ـ}S_Rɍ/]}7戾wZ<- F:r"c~}S_RҦI_QK`wQqy*:eز R[:̘ߚ"ew֘8"q<0E@ 2V=Pԝ$tG5P Nthgxz/5Jt(hEz:f0Tm:Gs洊appk͖5\Y14E˾&7戾wE1c_ROjo]Lo}ɍ/]}vׇJb) =ᚿ1 >*(2S#G[R2pN9MkfLo}6>ԙm1i Z#>HmҀT CD.Jb(V/̨c~}U'GэvT+TkhH\\r\œD_l2c~h}]SHV1 >)Ef)Uqd.ߚ"ewmRz/5Jc~}UtQƝu8t+*itQmɍ/]}yⱰRBQwSH khmktzk[(c~}VtM綜JJs46!i*ɍ/]}14E˾)+_joǢ3W踲c~h}FLo}붊b) =ᚿ1 >*(q *:3[K. Apxך"ewּG03}8%B[ uZռq2$򕤟BqC-1ZWDcÍ x&6>nEf)[zkjGCDc*8? fsci{Q{{d50s\14E˾&7戾wE1_R_jo]Lo}ɍ/]}vLE!XǢ3W=ᚿWEœD_l.51ƣ"mm:<8ؖ"x)wZ[mqj6J..I0@v+%ƞ(\ JAx4%ʬc>}TTsۣ`s vhd3KX yƱ\6?A'6-&Vej$p\Ah;r!14E˾&7戾wE1 z/5Jc~}Ut\Y14E˾&7戾wE1c_R_jo]Lk}[Qqy5\2ҫ!6JQa}S>$#S@i!j #k1NB~*m+YtBש4PV1 >*OG A"xGthg:-z5&Wu+2`ըXѼ5Ύ*D:KBJ-;GYh[Y`i@7ݓD_l2c ˾)*_joǢ3W踠ŘȚN- @@#YE|,+Mj5M)iβj\dm:`H=u]Ѵ袊DEQDDDEQDDDEQDDDEBXLXۏ";)դeH$AMQaAbb˻(Μ#*ѤF"hڠy $H/F  U! +E%.KHP6"⤨W*gH)Ѯ*m^ꅌs*o  iܥ|v fQQEQEQ1nDo.!uV%AYT$۞pDLo }^r( kŠh"Ļj3B4:5T?-%Ti3"D_D #4pjCE>RnLᰫ"(,""(""(m8mבI^[k~[^!ITśB$Z#ُ\=mUziMML{qm  !i[>:{zXu4L8 4DZ ((_<";%dqĶm\ZRP9nt q:(?@:#HI^ cV+TJ*TZdAb$Q .&}%/qr *gIQd=I-^+&7ӤjiihIH- qX\Fd.(""("" Ҵ袊DEQDDDEQDDDEQDDDEQDDDEQDDDEQDDDEQDDDEQDDDEQDDDEQDDDEQDDDEQDDDEQDDDEQDDDEQDDDEQDDDEQDDDEQDDDEQDDDEQDDDEQDDDEQDDDEQDDDExk)k03 8v"[%=I-J&MX&0p Qeւ8p2fMŎL^NI\uk-P'/(Xr&;['膐;ChIXiQcZֆԩ>4b(01dBѣ6Juj<f&&p  Ci`#DFRU1>xV@kLV1dn/üM۪4^ GXQ®ꗘYZh7kڼ"Xh7sVC#6킑/xD)YHaD%W:tfS *TtGSLSph7sqb--*hZX:gE4ѫT~=2jThu6clz]0JR(̈pNz- AmGS)ҔY6`6=V$\d]vSJP2 ΦZSdL= zARjN*nc(Rs ߭,MV4RT}J&9TSp©s㓖Zd'e8Bd е'(NRof J";LVVm=Pԑmg5 ñ!@dWz i>4Pֽhc*bǍ9nߝ^X(Zqq#ؒAŗ '=l¶,ᒦ$ʅĴ^Z7 O1Mޏ\d]e=i'LRXTjj[j:mss mZoԈs5l\`fTk0em-]}һh uXo$\V?jKYS yUN h\M!$u$Ђ&FByE1\]3sK[^N*mQso"D^pj/aDʴ#KBҙJiu)֩UIᵲ2)iwY8$8+ 8A@Ȱ"ǫV%QPalo7Շ 9'&y_8ю٥Q:Y*5E*LCu7SSw:.IjmjkSTeԙIX=X/Evr0iM1ԇ KNqY*mc׮m3XHVQ.@* AȖ9Ja#(w@@f"= i 쥤UhE=Pxi,~9/l@ Eֶt-Hm3Vi=`xO%ssaRA ͏.5 n8 Q(I qF/of3nDaRPGR)iIjm>Vb^\t.֩Hҵo[X֥MkCqM0ڎ6"^ KS}M*4XefX<:C@l{zTy ! P[E is5m_kJ$<\i$Di1Ȣ,HCVԕF x0Ȼ]5.FuJzP0kZXd;QV,\ =zOB)3S@[4 F9S&R>$$DZ\Bsɸ#ns^/H2Ny;n1ޅVjW`F\3e*/c4Td s:,H'bni~hWЈƏ=809?U6̧z)}fL u 2n SI]<*Q-,T[qa!v&N`nuң 2af8iQiTew*=usZ ŵkgzviZ3ikRuLl yc 7EQerQEQEQEQEQEQEԴ袊DEQDDDEQDDDEQDDDEQDDDEQDDDEQDDDEQDDDEQDDDExwW(seNIbEK̭WI NJj+f z&8C,46uQ<G&4d!jqwByAղOgaPR/\cٓHxH7/DŽ&%]>øh7Z'U 6$Aqueam58 $^.7 Hng)'p;)ǁXur5-r/fc, 6}Hq)S@CF\Xڱ}|ZDg$XML)L-kpgReX }띬N^/onu@-\a*PBcrڴ4g{XeZgJ{qiš]5>M4J5]R*sE J_1 /.mXѴ3FSF}"QHk)nx,IDmDOKpnDҨ asA<^j97)#2DRE6rh[Æ3̬[He!yo}/~ZB146䖆TgJ v;1(F2^u(hp PIt*9}7 Ɩ=wz%\CBb3.Q{y-B-Z T2P/C2xtiN:R)PpCZ%yARZz!]-=1GmvOX)Eä fxÓ|e1ujmv u̙IZj>q6Α$\6L%#Ӯ;%ė B"anqELqx86*6 䃦nzbAi FGښ=;JոimH80HǛՍ!L)X?HuJM{p qkZ4Auw=:5S(oGi.{+ccafe*YӭEE24\A8:D7oXBP/u( 獲c¤y8B.)RT&Y\ybKeIʞqJl-k:_D۷^!ϰIDOɹ$dIȼNV!׼>U=#54EcN:jXXƱh`.$F$Y:8h_gKqƚqr%i`80k޷]ChbGP5{\S%*Û2d2Jd]Ԣз"`qG:vX ވWeZ+6{do+GG]3UZ&::m*Nn7.D$ZmTf^@~& 1aq=o::4+Mԃ;E H$`.rz3fIRAQV&޳T&D*.,kh5>ѥa+a !ܡ[yKgmB,&eKԀV8%\ՇlyGvO~ EFZ*uGC h"P0RR7Ŋi5x)vBKѪ+}>T 2'"Gjݣt7:,z]JTh¤{p^/u%c[-8SeoԁQ2"bB{F*g m Jj7TJV\גhJv,&bvujxZ#Ov kk|HqyL˖xp]Ra})֦b%1{l"9.%QeR]ӤmjpA0&ViYҡTW6LTs]8t0b%DWC궛t6*Eg6h«isfag0Ά{hn]Z7x=M d}g$pi0`&kuKr :藂Śέn!o!A- ORu\ QK8 *yil+fCN&,}m!HD) gΕ,#q8K &V**TpE&#bht)i5&i6ցR m2\j 90汣g5OOINaw;+jCS2$CyHJ\eO {^!"aS)}WQ-\r.9h]jz=-3G/^FXncۈF!0`Hz4\Xp\8xb™\QM`8Ҥ;-l8"Ӓ Hʁk;6@Tiy2$<ə!f[v)))Z㒦h.׉<WtH= z#*a.9{&G#FөJ]JvMc&LH\PNl%12^i}e4[%(- Mm+n0RS,߭BHQ}@iajcwtw8F@.΍UJ﫡Ѭ)bED9 a牓s{%V Zʭp4Zִ..qE {& c}3)h f[y\=Y6vv]֣ѲfқQ*.u!uz1U*ԧM_ifO$)Ëm&EKg)Z!,pg_u5q8LX7d3 ̆\)Jj!A@)7ŶOLu=1hkq3H_ q&C:.[[F5kkb!-sKKp\J^leCIsB/1s+2=JZV88Oo֧}ICpFzڡ]tBJM:z(a'i-c(`k+$QZu\L 0lЊ-X 29qvYG}FSJ!&ؾ| P |^=Ed8 yDGra tT1/_|ح4z_hߢȧZkPSsdO \\&aafۭr*KJlkZ&qdvXe4uz~J6#ysY.cCm||"K ձm]m ZR*6n_i)&U4Pg!%NKNҖ\ ʥfmZGu8l3`Ly0ZYO,r7MVA#ߞi..} J] "&J;Pt7F5M-GK5mQ8\r_2+ñ%i!Z\ eH!LeB9TjS 0Ħ(h J|$].@=vth:n(7BM75]\BG "\3H"P-q!Hh`IUQEQEQEQEQEQEQEQEQ endstream endobj 2178 0 obj <>stream endstream endobj 2177 0 obj <>stream endstream endobj 2113 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 2114 0 obj <>/ExtGState<>/Font<>/ProcSet[/PDF/Text]/Properties<>/Shading<>/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 2115 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 2116 0 obj <>/Font<>/ProcSet[/PDF/Text/ImageB]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 2117 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 2187 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\037)31(\025\001\026\002\025\007\220\002\215\016\024\013\205 \227\220\002\n\215\007\ \205\002\001\013\205 \201\220\007\013\026)11(\013\227\220\205 \220\022\f\025\n)10(\025\r\013\205 )]TJ 0 -1 TD [(\221\025\201\n)10(\025\217\001\013\205 \006\225\220\001\n)-10(\026)11(\016\002\025\026)11(\025\024\220\205 \221\002\220\022\007\016\017\016\001\220\220 \207\002\025\ \001\220\017\016\006\n\220\207 )]TJ T* [(\013\001\013\007\216\001\020\207 \026\002\016\224\220\001 \r\022\006\025\ \017\016\026)11(\013\001\220\220 \006\022\202)10(\016\024\025\002\002\025\016\024 3\2344\022\006)-10(\026)11(\013\201\220\220)]TJ 32.735 2 Td [(\021ontr)20(olled cir)31(cular dilatation and later)21.1(al subcutaneous sphincter)20(otom)21(y )]TJ 4.673 -1 Td [(for chr)20.1(onic anal f)-20.9(issur)31(es associated with h)11(emorrh)11(oids III-IV)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0.202 Tw 10 0 0 10 42.5197 115.9299 Tm [(\217\026\f\023\030\036\007\036\035\036\027\017\036 )0.5(\023\026\006\017\036\027\021\024\r, \f\024\020\035\026\f\027\024 \024\002\ \255\036\n\031 \r\t\023\024\035)]TJ 0 Tw (-)Tj 0.125 Tw 0 -1.218 TD (\027\036\027\027\024\020\024 \024\023\036\030\026\021\017\r\027\024\020\024\ \r\n\036\001\026\021\036\035\034\f\021\r\026 \023\024)Tj /Span<>> BDC ( )Tj EMC (\023\024\r\024\007\031 \020\036)Tj 0 Tw (-)Tj T* (\n\024\030\030\024\016, \023\030\036\007\f\021\026\r\035\036\027\024 \r)Tj /Span<>> BDC ( )Tj EMC (\021\026\002\035\017\006\036 3.)Tj 1.233 Tw 23.244 2.436 Td (\215\024\007 \f\023\017\027\026\035\034\027\024\005 \026\027\036\f\021\036\ \017\036\005 \r)Tj /Span<>> BDC ( )Tj EMC (\023\024\035\024\032\036\027\017\017 )Tj 0.923 Tw T* (\230\030\036\027\007\036\035\036\027\002\031\030\020\026 \023\026\006\017\ \036\027\021\026\n \023\030\024\r\024\007\017\035\026\f\034 \030\036\r\017\ )Tj 0 Tw (-)Tj 0.409 Tw T* [(\017\016 )0.5(\026\027\026\035\034\027\024\020\024 \022\026\027\026\035\026 )0.5(\007\035\016 \024\006\036\027\022\017 )0.5(\n\036\f\021\027\024\020\024 \f\021\026)]TJ 0 Tw (-)Tj 0.693 Tw T* (\021\031\f\026. \215\026\006\017\036\027\021\026\n \024\f\027\024\r\027\024\ \005 \020\030\031\023\023\t \r)Tj /Span<>> BDC ( )Tj EMC (\022\026\004\036\f\021\r\036 )Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0 Tw 9 0 0 9 42.5197 730.483 Tm (\020\004\206\f\t\204\004 1.)Tj 0 0 0 1 k /GS1 gs /T1_3 1 Tf ( \206\026\032\026\013\024\031\032\025\t\024\025\013\026 \033\026\203\025\ \031\021\024\n\027)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0 -1.2 TD [(T)48(able 1)47(.)]TJ 0 0 0 1 k /GS1 gs /T1_3 1 Tf [( Character)-36.9(istics of patients)]TJ ET 0 0 0 1 K 0.5 w /GS2 gs q 1 0 0 1 42.5197 715.181 cm 0 0 m 170.329 0 l S Q q 1 0 0 1 42.7697 703.7117 cm 0 0 m 0 11.219 l S Q q 1 0 0 1 212.8484 715.181 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 212.8484 703.9617 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 326.2343 715.181 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 439.6201 715.181 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 439.6201 703.9617 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 496.313 703.7117 cm 0 0 m 0 11.219 l S Q q 1 0 0 1 42.7697 682.8925 cm 0 0 m 0 20.819 l S Q q 1 0 0 1 212.5984 703.7117 cm 0 0 m 113.636 0 l S Q q 1 0 0 1 212.8484 682.8925 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 326.2343 703.7117 cm 0 0 m 113.636 0 l S Q q 1 0 0 1 326.2343 682.8925 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 439.6201 682.8925 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 496.313 682.8925 cm 0 0 m 0 20.819 l S Q q 1 0 0 1 42.5197 682.6425 cm 0 0 m 170.329 0 l S Q q 1 0 0 1 42.7697 671.4313 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 212.8484 682.6425 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 212.8484 671.4313 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 326.2343 682.6425 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 326.2343 671.4313 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 439.6201 682.6425 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 439.6201 671.4313 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 671.4313 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 671.1813 cm 0 0 m 170.329 0 l S Q q 1 0 0 1 42.7697 659.97 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 212.8484 671.1813 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 212.8484 659.97 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 326.2343 671.1813 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 326.2343 659.97 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 439.6201 671.1813 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 439.6201 659.97 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 659.97 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 659.72 cm 0 0 m 170.329 0 l S Q q 1 0 0 1 42.7697 629.3087 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 212.8484 659.72 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 212.8484 629.3087 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 326.2343 659.72 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 326.2343 629.3087 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 439.6201 659.72 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 439.6201 629.3087 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 496.313 629.3087 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 42.5197 629.0587 cm 0 0 m 170.329 0 l S Q q 1 0 0 1 42.7697 617.8474 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 212.8484 629.0587 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 212.8484 617.8474 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 326.2343 629.0587 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 326.2343 617.8474 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 439.6201 629.0587 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 439.6201 617.8474 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 617.8474 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 617.5974 cm 0 0 m 170.329 0 l S Q q 1 0 0 1 42.7697 606.3861 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 212.8484 617.5974 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 212.8484 606.3861 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 326.2343 617.5974 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 326.2343 606.3861 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 439.6201 617.5974 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 439.6201 606.3861 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 606.3861 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 606.1361 cm 0 0 m 170.329 0 l S Q q 1 0 0 1 42.7697 566.1248 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 212.8484 606.1361 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 212.8484 566.1248 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 326.2343 606.1361 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 326.2343 566.1248 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 439.6201 606.1361 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 439.6201 566.1248 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 496.313 566.1248 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 42.5197 565.8748 cm 0 0 m 170.329 0 l S Q q 1 0 0 1 42.7697 535.4636 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 212.8484 565.8748 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 212.8484 535.4636 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 326.2343 565.8748 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 326.2343 535.4636 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 439.6201 565.8748 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 439.6201 535.4636 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 496.313 535.4636 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 42.5197 535.2136 cm 0 0 m 170.329 0 l S Q q 1 0 0 1 42.7697 524.0023 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 212.8484 535.2136 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 212.8484 524.0023 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 326.2343 535.2136 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 326.2343 524.0023 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 439.6201 535.2136 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 439.6201 524.0023 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 524.0023 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 523.7523 cm 0 0 m 170.329 0 l S Q q 1 0 0 1 42.7697 512.541 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 212.8484 523.7523 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 212.8484 512.541 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 326.2343 523.7523 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 326.2343 512.541 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 439.6201 523.7523 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 439.6201 512.541 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 512.541 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 512.291 cm 0 0 m 170.329 0 l S Q q 1 0 0 1 42.7697 501.0797 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 212.8484 512.291 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 212.8484 501.0797 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 326.2343 512.291 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 326.2343 501.0797 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 439.6201 512.291 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 439.6201 501.0797 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 501.0797 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 500.8297 cm 0 0 m 170.329 0 l S Q q 1 0 0 1 42.7697 470.4184 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 212.8484 500.8297 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 212.8484 470.4184 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 326.2343 500.8297 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 326.2343 470.4184 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 439.6201 500.8297 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 439.6201 470.4184 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 496.313 470.4184 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 42.5197 470.1684 cm 0 0 m 170.329 0 l S Q q 1 0 0 1 212.8484 470.1684 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 326.2343 470.1684 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 439.6201 470.1684 cm 0 0 m 56.943 0 l S Q BT /GS1 gs /T1_2 1 Tf 8 0 0 8 107.8653 696.0117 Tm (\200\002\220\004\213\004\003\r\f\001)Tj 16.742 1.317 Td (\215\r\003\002\240 \f\t\220\t\240\004\204\t\t \217\212\004\213\214\004 \ \004\b\004\f\001\b\002\n\002 \217\226\t\b\220\003\r\006\004)Tj /T1_4 1 Tf 28.011 -1.316 Td (p)Tj /T1_2 1 Tf -25.442 -0.117 Td (\021\037\031)Tj -0.489 -1.2 Td (N)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (48)Tj 14.708 1.2 Td (\225\200\255)Tj -0.535 -1.2 Td (N)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (46)Tj /T1_1 1 Tf -40.777 -1.433 Td (\204\036\007\017\026\027\026 \r\024\030\026\f\021\026 \(\022\r\026\030\021\ \017\035\017\))Tj 25.049 0 Td (45,5)Tj /Span<>> BDC ( )Tj EMC (\(38,5; 50\))Tj 14.866 0 Td (40)Tj /Span<>> BDC ( )Tj EMC (\(36: 47\))Tj 12.038 0 Td (0,12)Tj -51.953 -1.433 Td (\204\036\007\017\026\027\026 \222\204\230 \(\022\r\026\030\021\017\035\017\ \))Tj 24.706 0 Td (27,7)Tj /Span<>> BDC ( )Tj EMC (\(24,7; 29,8\))Tj 14.173 0 Td (26,7)Tj /Span<>> BDC ( )Tj EMC (\(22,1; 31,6\))Tj 13.073 0 Td (0,35)Tj -51.953 -1.433 Td (\215\024\035)Tj 0 -1.2 TD (\204)Tj 0 -1.2 TD (\240)Tj 25.784 1.2 Td (31)Tj /Span<>> BDC ( )Tj EMC (\(64,6%\))Tj T* (17)Tj /Span<>> BDC ( )Tj EMC (\(35,4%\))Tj 14.173 1.2 Td (20)Tj /Span<>> BDC ( )Tj EMC (\(43,5%\))Tj T* (26)Tj /Span<>> BDC ( )Tj EMC (\(56,5%\))Tj 11.996 2.4 Td (0,12)Tj -51.953 -3.833 Td (\212\035\017\021\036\035\034\027\024\f\021\034 \026\002\024\035\036\r\026\ \027\017\016, \n\036\f)Tj 25.484 0 Td (24)Tj /Span<>> BDC ( )Tj EMC (\(26; 108\))Tj 14.423 0 Td (24)Tj /Span<>> BDC ( )Tj EMC (\(12; 60\))Tj 12.046 0 Td (0,15)Tj -51.953 -1.433 Td (\204\036\007\017\026\027\026 \002\024\035\036\r\024\020\024 \f\017\027\007\ \030\024\n\026, \002\026\035\035\t)Tj 26.6 0 Td (7)Tj /Span<>> BDC ( )Tj EMC (\(6;8\))Tj 14.173 0 Td (6)Tj /Span<>> BDC ( )Tj EMC (\(5;7\))Tj 10.929 0 Td (0,006)Tj -51.703 -1.433 Td (\217\024\007\t N)Tj 0 -1.2 TD (1)Tj T* (2)Tj T* (3)Tj 26.034 2.4 Td (6)Tj /Span<>> BDC ( )Tj EMC (\(12,5%\))Tj T* (8)Tj /Span<>> BDC ( )Tj EMC (\(16,7%\))Tj 0.25 -1.2 Td (2)Tj /Span<>> BDC ( )Tj EMC (\(4,2%\))Tj 13.673 2.4 Td (10)Tj /Span<>> BDC ( )Tj EMC (\(21,7%\))Tj 0.25 -1.2 Td (8)Tj /Span<>> BDC ( )Tj EMC (\(17,4%\))Tj 1.708 -1.2 Td (0)Tj 10.037 2.4 Td (0,29)Tj -51.953 -3.833 Td (\230\030\036\013\017\027\026, N)Tj T* (1)Tj 0 -1.2 TD (2)Tj 25.784 1.2 Td (44)Tj /Span<>> BDC ( )Tj EMC (\(91,7%\))Tj 0.5 -1.2 Td (4)Tj /Span<>> BDC ( )Tj EMC (\(8,3%\))Tj 13.766 1.2 Td (46)Tj /Span<>> BDC ( )Tj EMC (\(100%\))Tj 1.866 -1.2 Td (0)Tj 10.037 1.2 Td (0,27)Tj -51.953 -2.633 Td (\205\017\002\030\024\027\t\005 \023\024\035\017\023)Tj 26.034 0 Td (5)Tj /Span<>> BDC ( )Tj EMC (\(10,4%\))Tj 14.266 0 Td (12)Tj /Span<>> BDC ( )Tj EMC (\(26%\))Tj 12.246 0 Td (1)Tj -52.545 -1.433 Td (\221\021\024\030\024\032\036\r\024\005 \002\031\020\024\030\024\022)Tj 26.034 0 Td (5)Tj /Span<>> BDC ( )Tj EMC (\(10,4%\))Tj 14.266 0 Td (12)Tj /Span<>> BDC ( )Tj EMC (\(26%\))Tj 12.246 0 Td (1)Tj -52.545 -1.433 Td (\203\026\030\031\032\027\t\005 \020\036\n\024\030\030\024\005)Tj 25.876 0 Td (48)Tj /Span<>> BDC ( )Tj EMC (\(100%\))Tj 14.173 0 Td (46)Tj /Span<>> BDC ( )Tj EMC (\(100%\))Tj 12.496 0 Td (1)Tj -52.545 -1.433 Td (\200\027\031\021\030\036\027\027\017\005 \020\036\n\024\030\030\024\005)Tj 0 -1.2 TD (3 \f\021\026\007\017\016)Tj T* (4 \f\021\026\007\017\016)Tj 25.784 1.2 Td (34)Tj /Span<>> BDC ( )Tj EMC (\(70,8%\))Tj T* (14)Tj /Span<>> BDC ( )Tj EMC (\(29,2%\))Tj 14.173 1.2 Td (31)Tj /Span<>> BDC ( )Tj EMC (\(67,4%\))Tj T* (15)Tj /Span<>> BDC ( )Tj EMC (\(32,6%\))Tj 12.588 1.2 Td (1)Tj -0.592 -1.2 Td (0,83)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 9 0 0 9 42.5197 453.4491 Tm (\020\004\206\f\t\204\004 2.)Tj 0 0 0 1 k /GS1 gs /T1_3 1 Tf ( \207\024\032\205\013\024\205\032\026 \t\n\033\205\024\t\024\027\205\007\ \211\025\004 \016\026\005\n\023\031\027\026\021\025\017)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf T* [(T)48(able 2)16(.)]TJ 0 0 0 1 k /GS1 gs /T1_3 1 Tf [( S)28(tructure of comorbidities)]TJ ET /GS2 gs q 1 0 0 1 42.5197 438.1471 cm 0 0 m 170.329 0 l S Q q 1 0 0 1 42.7697 426.6779 cm 0 0 m 0 11.219 l S Q q 1 0 0 1 212.8484 438.1471 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 212.8484 426.9279 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 326.2343 438.1471 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 439.6201 438.1471 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 439.6201 426.9279 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 496.313 426.6779 cm 0 0 m 0 11.219 l S Q q 1 0 0 1 42.7697 405.8587 cm 0 0 m 0 20.819 l S Q q 1 0 0 1 212.5984 426.6779 cm 0 0 m 113.636 0 l S Q q 1 0 0 1 212.8484 405.8587 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 326.2343 426.6779 cm 0 0 m 113.636 0 l S Q q 1 0 0 1 326.2343 405.8587 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 439.6201 405.8587 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 496.313 405.8587 cm 0 0 m 0 20.819 l S Q q 1 0 0 1 42.5197 405.6087 cm 0 0 m 170.329 0 l S Q q 1 0 0 1 42.7697 394.3974 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 212.8484 405.6087 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 212.8484 394.3974 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 326.2343 405.6087 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 326.2343 394.3974 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 439.6201 405.6087 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 439.6201 394.3974 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 394.3974 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 394.1474 cm 0 0 m 170.329 0 l S Q q 1 0 0 1 42.7697 382.9361 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 212.8484 394.1474 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 212.8484 382.9361 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 326.2343 394.1474 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 326.2343 382.9361 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 439.6201 394.1474 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 439.6201 382.9361 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 382.9361 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 382.6861 cm 0 0 m 170.329 0 l S Q q 1 0 0 1 42.7697 371.4749 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 212.8484 382.6861 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 212.8484 371.4749 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 326.2343 382.6861 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 326.2343 371.4749 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 439.6201 382.6861 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 439.6201 371.4749 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 371.4749 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 371.2249 cm 0 0 m 170.329 0 l S Q q 1 0 0 1 42.7697 350.4135 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 212.8484 371.2249 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 212.8484 350.4135 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 326.2343 371.2249 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 326.2343 350.4135 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 439.6201 371.2249 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 439.6201 350.4135 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 496.313 350.4135 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 42.5197 350.1635 cm 0 0 m 170.329 0 l S Q q 1 0 0 1 42.7697 338.9523 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 212.8484 350.1635 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 212.8484 338.9523 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 326.2343 350.1635 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 326.2343 338.9523 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 439.6201 350.1635 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 439.6201 338.9523 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 338.9523 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 338.7023 cm 0 0 m 170.329 0 l S Q q 1 0 0 1 42.7697 327.491 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 212.8484 338.7023 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 212.8484 327.491 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 326.2343 338.7023 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 326.2343 327.491 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 439.6201 338.7023 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 439.6201 327.491 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 327.491 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 327.241 cm 0 0 m 170.329 0 l S Q q 1 0 0 1 42.7697 316.0297 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 212.8484 327.241 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 212.8484 316.0297 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 326.2343 327.241 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 326.2343 316.0297 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 439.6201 327.241 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 439.6201 316.0297 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 316.0297 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 315.7797 cm 0 0 m 170.329 0 l S Q q 1 0 0 1 42.7697 304.5684 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 212.8484 315.7797 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 212.8484 304.5684 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 326.2343 315.7797 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 326.2343 304.5684 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 439.6201 315.7797 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 439.6201 304.5684 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 304.5684 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 304.3184 cm 0 0 m 170.329 0 l S Q q 1 0 0 1 42.7697 293.1071 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 212.8484 304.3184 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 212.8484 293.1071 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 326.2343 304.3184 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 326.2343 293.1071 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 439.6201 304.3184 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 439.6201 293.1071 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 293.1071 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 292.8571 cm 0 0 m 170.329 0 l S Q q 1 0 0 1 42.7697 281.6459 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 212.8484 292.8571 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 212.8484 281.6459 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 326.2343 292.8571 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 326.2343 281.6459 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 439.6201 292.8571 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 439.6201 281.6459 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 281.6459 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 281.3959 cm 0 0 m 170.329 0 l S Q q 1 0 0 1 42.7697 270.1846 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 212.8484 281.3959 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 212.8484 270.1846 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 326.2343 281.3959 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 326.2343 270.1846 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 439.6201 281.3959 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 439.6201 270.1846 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 270.1846 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 269.9346 cm 0 0 m 170.329 0 l S Q q 1 0 0 1 42.7697 249.1233 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 212.8484 269.9346 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 212.8484 249.1233 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 326.2343 269.9346 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 326.2343 249.1233 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 439.6201 269.9346 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 439.6201 249.1233 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 496.313 249.1233 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 42.5197 248.8733 cm 0 0 m 170.329 0 l S Q q 1 0 0 1 212.8484 248.8733 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 326.2343 248.8733 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 439.6201 248.8733 cm 0 0 m 56.943 0 l S Q BT /GS1 gs /T1_2 1 Tf 8 0 0 8 105.1972 418.9779 Tm (\033\004\206\002\f\r\004\b\t\r)Tj 21.907 1.317 Td (\215\r\003\002\240 \f\t\220\t\240\004\204\t\t \217\212\004\213\214\004)Tj /T1_4 1 Tf 23.18 -1.316 Td (\n)Tj /T1_2 1 Tf -25.442 -0.117 Td (\021\037\031)Tj -0.489 -1.2 Td (N)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (48)Tj 14.708 1.2 Td (\225\200\255)Tj -0.535 -1.2 Td (N)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (46)Tj /T1_1 1 Tf -40.777 -1.433 Td (\202\030\021\036\030\017\026\035\034\027\026\016 \020\017\023\036\030\021\ \036\027\017\016)Tj 25.784 0 Td (14)Tj /Span<>> BDC ( )Tj EMC (\(29,2%\))Tj 14.423 0 Td (8)Tj /Span<>> BDC ( )Tj EMC (\(17,4%\))Tj 11.746 0 Td (0,57)Tj -51.953 -1.433 Td (\222\001\036\n\017\004\036\f\022\026\016 \002\024\035\036\027\034 \f\036\ \030\007\006\026)Tj 26.284 0 Td (4)Tj /Span<>> BDC ( )Tj EMC (\(8,3%\))Tj 15.632 0 Td (0)Tj 10.287 0 Td (0,3)Tj -52.203 -1.433 Td (\224\n\235\017\036\n\026 \035\036\020\022\017\b)Tj 26.626 0 Td (1)Tj /Span<>> BDC ( )Tj EMC (\(2%\))Tj 15.289 0 Td (0)Tj 10.63 0 Td (1)Tj -52.545 -1.433 Td (\230\030\024\n\002\024\021\017\004\036\f\022\026\016 \n\017\022\030\024\026\ \027\020\017\024\023\026\021\017\016. )Tj T* (\206\036\n\024\030\030\026\020\017\004\036\f\022\017\005 \r\026\f\022\031\ \035\017\021)Tj 27.742 1.2 Td (0)Tj 12.465 0 Td (1)Tj /Span<>> BDC ( )Tj EMC (\(2,17%\))Tj 11.746 0 Td (0,33)Tj -51.953 -2.633 Td (\230\030\024\n\002\024\235\017\035\017\016)Tj 26.626 0 Td (1)Tj /Span<>> BDC ( )Tj EMC (\(2%\))Tj 15.289 0 Td (0)Tj 10.63 0 Td (1)Tj -52.545 -1.433 Td (\221\026\b\026\030\027\t\005 \007\017\026\002\036\021)Tj 27.742 0 Td (0)Tj 12.715 0 Td (4)Tj /Span<>> BDC ( )Tj EMC (\(8,7%\))Tj 11.496 0 Td (0,11)Tj -51.953 -1.433 Td (\247\207\240*)Tj 26.626 0 Td (1)Tj /Span<>> BDC ( )Tj EMC (\(2%\))Tj 15.289 0 Td (0)Tj 10.63 0 Td (1)Tj -52.545 -1.433 Td (\216\210\207\214**)Tj 27.742 0 Td (0)Tj 12.715 0 Td (2)Tj /Span<>> BDC ( )Tj EMC (\(4,4%\))Tj 11.496 0 Td (0,33)Tj -51.953 -1.433 Td (\200\017\030\031\f\027\t\005 \020\036\023\026\021\017\021 \200)Tj 26.626 0 Td (1)Tj /Span<>> BDC ( )Tj EMC (\(2%\))Tj 15.289 0 Td (0)Tj 10.63 0 Td (1)Tj -52.545 -1.433 Td (\221\017\235\017\035\017\f)Tj 27.742 0 Td (0)Tj 12.465 0 Td (1)Tj /Span<>> BDC ( )Tj EMC (\(2,17%\))Tj 11.746 0 Td (0,33)Tj -51.953 -1.433 Td (\210\032\017\030\036\027\017\036)Tj 26.034 0 Td (3)Tj /Span<>> BDC ( )Tj EMC (\(6,25%\))Tj 14.173 0 Td (1)Tj /Span<>> BDC ( )Tj EMC (\(2,17%\))Tj 11.746 0 Td (0,37)Tj -51.953 -1.433 Td (\200\f\036\020\024 \023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\f\024\023\031\021\f\021\r\031\033\013\017\n\017 )Tj T* (\f\024\n\026\021\017\004\036\f\022\017\n\017 \026\002\024\035\036\r\026\ \027\017\016\n\017)Tj 25.784 1.2 Td (18)Tj /Span<>> BDC ( )Tj EMC (\(37,5%\))Tj 14.173 0 Td (16)Tj /Span<>> BDC ( )Tj EMC (\(34,7%\))Tj 12.588 0 Td (1)Tj /T1_3 1 Tf 7 0 0 7 42.5197 237.3886 Tm (\032\025\003\031\006\026\021\025\031: * \243\213\241)Tj /Span<>> BDC ( )Tj EMC [(\227 \002\016\027\031\021\021\026\002 \005\n\023\031\016\021\022 \204\031\ \023\205)34.4(\030\013\026, ** \206\255\213\035)]TJ /Span<>> BDC ( )Tj EMC (\227 \004\032\n\021\025\006\031\t\013\026\002 \n\005\t\024\032\205\013\024\ \025\027\021\026\002 \005\n\023\031\016\021\022 \023\031\202\013\025\004\ )Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 9 0 0 9 42.5197 218.0847 Tm (\020\004\206\f\t\204\004 3.)Tj 0 0 0 1 k /GS1 gs /T1_3 1 Tf ( \255\005\b\031\003 \n\033\031\032\026\024\025\027\021\n\202\n \027\003\031\ \001\026\024\031\023\022\t\024\027 \033\n)Tj /Span<>> BDC ( )Tj EMC [(\033\n\027\n\030\205 \t\n\033\205\024\t\024\027)0.5(\205\007\211\031\202\n \202\031\003\n\032\032\n\002)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0 -1.2 TD [(T)48(able 3.)]TJ 0 0 0 1 k /GS1 gs /T1_3 1 Tf [( The v)13.1(olume of surgical inter)-41.8(v)13(ention for concomitant hemor)-15.7(rhoids)]TJ ET /GS2 gs q 1 0 0 1 42.5197 202.7827 cm 0 0 m 173.163 0 l S Q q 1 0 0 1 42.7697 172.3635 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 215.6831 202.7827 cm 0 0 m 119.055 0 l S Q q 1 0 0 1 215.6831 172.3635 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 334.7382 202.7827 cm 0 0 m 119.055 0 l S Q q 1 0 0 1 334.7382 172.3635 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 453.7933 202.7827 cm 0 0 m 42.77 0 l S Q q 1 0 0 1 453.7933 172.3635 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 496.313 172.3635 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 42.5197 172.1135 cm 0 0 m 173.163 0 l S Q q 1 0 0 1 42.7697 151.3022 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 215.6831 172.1135 cm 0 0 m 119.055 0 l S Q q 1 0 0 1 215.6831 151.3022 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 334.7382 172.1135 cm 0 0 m 119.055 0 l S Q q 1 0 0 1 334.7382 151.3022 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 453.7933 172.1135 cm 0 0 m 42.77 0 l S Q q 1 0 0 1 453.7933 151.3022 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 496.313 151.3022 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 42.5197 151.0522 cm 0 0 m 173.163 0 l S Q q 1 0 0 1 42.7697 139.8409 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 215.6831 151.0522 cm 0 0 m 119.055 0 l S Q q 1 0 0 1 215.6831 139.8409 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 334.7382 151.0522 cm 0 0 m 119.055 0 l S Q q 1 0 0 1 334.7382 139.8409 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 453.7933 151.0522 cm 0 0 m 42.77 0 l S Q q 1 0 0 1 453.7933 139.8409 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 139.8409 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 139.5909 cm 0 0 m 173.163 0 l S Q q 1 0 0 1 215.6831 139.5909 cm 0 0 m 119.055 0 l S Q q 1 0 0 1 334.7382 139.5909 cm 0 0 m 119.055 0 l S Q q 1 0 0 1 453.7933 139.5909 cm 0 0 m 42.77 0 l S Q BT /GS1 gs /T1_2 1 Tf 8 0 0 8 109.2827 184.5481 Tm (\200\002\220\004\213\004\003\r\f\001)Tj 14.642 1.2 Td (\200\004\204\t\r\b\003\013 \002\217\b\002\b\002\005 \n\006\210\212\212\013\ )Tj 4.756 -1.2 Td (\(\021\037\031\))Tj -0.046 -1.2 Td (N)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (48)Tj 9.413 2.4 Td (\200\004\204\t\r\b\003\013 \220\002\b\003\006\002\f\001\b\002\005 \n\006\ \210\212\212\013 )Tj 5.56 -1.2 Td (\(\225\200\255\))Tj -0.091 -1.2 Td (N)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (46)Tj /T1_4 1 Tf 11.224 1.2 Td (\021)Tj /T1_1 1 Tf -53.419 -2.633 Td (\212\036\026\030\021\036\030\017\026\006\017\016 \r\027\031\021\030\036\ \027\027\017\b \020\036\n\024\030\030\024\017\007\026\035\034\027\t\b )Tj 0 -1.2 TD (\031\035\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\n\031\022\024\023\036\022\f\017\036\005, \017\f\f\036\004\036\027\017\036\ \027\026\030\031\032\027\t\b \031\035\024\r)Tj 26.492 1.2 Td (34)Tj /Span<>> BDC ( )Tj EMC (\(70,8%\))Tj 14.882 0 Td (31)Tj /Span<>> BDC ( )Tj EMC (\(67,4%\))Tj 12.057 0 Td (1)Tj -53.431 -2.633 Td (\206\036\n\024\030\030\024\017\007\220\022\021\024\n\017\016)Tj 26.492 0 Td (14)Tj /Span<>> BDC ( )Tj EMC (\(29,2%\))Tj 14.882 0 Td (15)Tj /Span<>> BDC ( )Tj EMC (\(32,6%\))Tj 11.464 0 Td (0,83)Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\033\030\031\030\213\b)-20.9(\035\231\213\233\t \021\032)50(\b)42(\032\231\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj /T1_5 1 Tf 25 0 0 25 512.8646 56.0378 Tm (45)Tj ET endstream endobj 2185 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 0.01 Tc 0.018 Tw 14 0 0 14 70.936 724.8299 Tm [(\f\026\017\031\034\022\024\232)5( \031)5(\016)-18.3(\240\034)-31(\024)35(\037\226\232)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0.008 Tc 0.103 Tw 10 0 0 10 70.8661 700.4739 Tm (\221 \f\036\027\021\016\002\030\016 2017 \020. \023\024)Tj /Span<>> BDC ( )Tj EMC (\016\027\r\026\030\034 2022 \020. \027\026)Tj /Span<>> BDC ( )Tj EMC [(\002\026\036 \205\206\207\211)8( )]TJ 0.157 Tw 0 -1.218 TD [(\253\203\204\222\037 )0.5(\022\024\035\024\023\030\024\022\021\024\035\024\020\017\017 )0.5(\017\n\036\027\017 )0.5(\202.\203. )0.5(\217\t\032\017\b\273 )0.5(\002\t\035\024)8( )]TJ 0.284 Tw T* (\023\030\024\r\036\007\036\027\024 \024\007\027\024\006\036\027\021\030\024\ \r\024\036 \023\030\024\f\023\036\022\021\017\r\027\024\036 \f\030\026\r\ \027\017)Tj 0 Tc 0 Tw (-)Tj 0.008 Tc 0.138 Tw T* [(\021\036\035\034\027\024\036 )0.5(\030\026\027\007\024\n\017\017\030\024\r\026\027\027\024\036 )0.5(\022\035\017\027\017\004\036\f\022\024\036 \017\f\f\035\036\007\024)]TJ 0 Tc 0 Tw (-)Tj 0.008 Tc 0.061 Tw T* (\r\026\027\017\036. \200)Tj /Span<>> BDC ( )Tj EMC [(\017\f\f\035\036\007\024\r\026\027\017\036 \002\t\035\024 \r\022\035\033\ \004\036\027\024 94 \023\026\006\017\036\027\021\026)8( )]TJ 0.24 Tw 0 -1.218 TD (\f)Tj /Span<>> BDC ( )Tj EMC [(\b\030\024\027\017\004\036\f\022\024\005 \026\027\026\035\034\027\024\005\ \021\030\036\013\017\027\024\005, \f\024\004\036\021\026\033\013\036\005\ \f\016)8( )]TJ -0.004 Tw 0 -1.218 TD (\f)Tj /Span<>> BDC ( )Tj EMC (\022\024\n\002\017\027\017\030\024\r\026\027\027\t\n \020\036\n\024\030\030\ \024\036\n 3\2264)Tj /Span<>> BDC ( )Tj EMC [(\f\021\026\007\017\017, \022\024\021\024\030\t\036)8( )]TJ 0.41 Tw T* (\002\t\035\017 \030\026\027\007\024\n\017\017\030\024\r\026\027\t \n\036\ \021\024\007\024\n \020\036\027\036\030\026\006\017\017 \f\035\031)Tj 0 Tc 0 Tw (-)Tj 0.008 Tc 0.128 Tw T* (\004\026\005\027\t\b \004\017\f\036\035 \r)Tj /Span<>> BDC ( )Tj EMC (\022\024\n\023\034\033\021\036\030\027\024\005 \023\030\024\020\030\026\n\ \n\036 \r)Tj /Span<>> BDC ( )Tj EMC (\024\f\027\024\r)Tj 0 Tc 0 Tw (-)Tj 0.008 Tc 0.025 Tw T* (\027\031\033 \(\210\206\) \017)Tj /Span<>> BDC ( )Tj EMC (\022\024\027\021\030\024\035\034\027\031\033 \(\025\206\) \020\030\031\023\ \023\t. \200)Tj /Span<>> BDC ( )Tj EMC [(\210\206 \r\024\001\035\024 48)8( )]TJ 0.125 Tw 0 -1.218 TD (\023\026\006\017\036\027\021\024\r, \022\024\021\024\030\t\n \r)Tj /Span<>> BDC ( )Tj EMC [(\022\026\004\036\f\021\r\036 \n\036\021\024\007\026 \035\017\022\r\017\007\ \026\006\017\017)7.9( )]TJ 0.067 Tw 0 -1.218 TD (\f\023\026\n\026 \200\202\221 \002\t\035\026 \r\t\023\024\035\027\036\027\ \026 \025\037\212 \026\027\026\035\034\027\024\020\024 \f\235\017\027\022\ )Tj 0 Tc 0 Tw (-)Tj 0.008 Tc 0.11 Tw 0 -1.218 TD (\021\036\030\026, \r)Tj /Span<>> BDC ( )Tj EMC (\022\024\027\021\030\024\035\034\027\031\033 \020\030\031\023\023\031)Tj /Span<>> BDC ( )Tj EMC (\227 46 \023\026\006\017\036\027\021\024\r, \022\024\021\024)Tj 0 Tc 0 Tw (-)Tj 0.008 Tc 0.156 Tw 0 -1.218 TD [(\030\t\n \002\t\035\026 \r\t\023\024\035\027\036\027\026 \207\215\221. \215\ \026\006\017\036\027\021\026\n \024\002\036\017\b \020\030\031\023\023)8( )]TJ 0.211 Tw 0 -1.218 TD (\r\t\023\024\035\027\016\035\024\f\034 \017\f\f\036\004\036\027\017\036 \ \021\030\036\013\017\027\t \017)Tj /Span<>> BDC ( )Tj EMC [(\b\017\030\031\030\020\017\004\036\f\022\024\036)8( )]TJ 0.091 Tw 0 -1.218 TD (\035\036\004\036\027\017\036 \f\024\023\031\021\f\021\r\031\033\013\036\020\ \024 \020\036\n\024\030\030\024\016 \r)Tj /Span<>> BDC ( )Tj EMC (\024\002\255\036\n\036 \007\036\026\030)Tj 0 Tc 0 Tw (-)Tj 0.008 Tc 0.001 Tw 0 -1.218 TD (\021\036\030\017\026\006\017\017 \r\027\031\021\030\036\027\027\017\b \020\ \036\n\024\030\030\024\017\007\026\035\034\027\t\b \031\035\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\n\031)Tj 0 Tc 0 Tw (-)Tj 0.008 Tc 0.026 Tw 0 -1.218 TD (\022\024\023\036\022\f\017\036\005 \017\035\017 \020\036\n\024\030\030\024\ \017\007\220\022\021\024\n\017\017, \r)Tj /Span<>> BDC ( )Tj EMC [(\026\r\017\f\017\n\024\f\021\017 \024\021)7.9( )]TJ 0 Tw T* (\036\020\024 \f\021\026\007\017\017.)Tj /T1_2 1 Tf 0 Tc 0.146 Tw 0 -1.218 TD (\021\006\t\003\r\006\t\t \220\f\211\201\r\b\t\235 \212\004\204\t\r\b\003\ \002 )Tj /Span<>> BDC ( )Tj EMC (\t\217\217\f\r\240\002\004\b\t\r:)Tj /T1_1 1 Tf 0 Tw ( )Tj 0.207 Tw 0 -1.218 TD [(\b\030\024\027\017\004\036\f\022\026\016 )0.6(\026\027\026\035\034\027\026\016 )0.5(\021\030\036\013\017\027\026 )0.6(\f\024 )0.5(\f\023\026\n\024\n )0.5(\f\235\017\027\022)]TJ 0 Tw (-)Tj 0.192 Tw 0 -1.218 TD (\021\036\030\026 \f)Tj /Span<>> BDC ( )Tj EMC [(\f\024\023\031\021\f\021\r\031\033\013\017\n )0.6(\027\026\030\031\032\027\t\n \017)]TJ /Span<>> BDC ( )Tj EMC 15.607 0 Td [(\r\027\031\021\030\036\027\027\017\n )0.5(\020\036)]TJ 0 Tw (-)Tj -0.043 Tw -15.607 -1.218 Td (\n\024\030\030\024\036\n 3\2264)Tj /Span<>> BDC ( )Tj EMC (\f\021\026\007\017\017; \r\024\030\026\f\021 18 \035\036\021 \017)Tj /Span<>> BDC ( )Tj EMC (\f\021\026\030\001\036; \017\027\235\024\030)Tj 0 Tw (-)Tj 0.085 Tw T* [(\n\017\030\024\r\026\027\027\024\036 )0.5(\f\024\020\035\026\f\017\036 )0.6(\023\026\006\017\036\027\021\026 )0.5(\027\026)]TJ /Span<>> BDC ( )Tj EMC 14.739 0 Td [(\023\030\017\027\016\021\017\036 )0.6(\031\004\026\f\021\017\016 )]TJ 0 Tw -14.739 -1.218 Td (\r)Tj /Span<>> BDC ( )Tj EMC (\017\f\f\035\036\007\024\r\026\027\017\017.)Tj /T1_2 1 Tf 0.008 Tc 0.301 Tw T* (\021\006\t\003\r\006\t\t \b\r \220\f\211\201\r\b\t\235 \212\004\204\t\r\ \b\003\002 )Tj /Span<>> BDC ( )Tj EMC (\t\217\217\f\r\240\002)Tj 0 Tc 0 Tw (-)Tj 0.008 Tc -0.008 Tw T* (\004\b\t\r: )Tj /T1_1 1 Tf 0.249 Tw 3.428 0 Td [(\027\026\035\017\004\017\036 \023\030\016\n\024\022\017\001\036\004\027\t\ \b \f\r\017\013\036\005; \027\026\035\017\004\017\036)8( )]TJ 0.126 Tw 19.816 34.098 Td (\r\t\030\026\032\036\027\027\t\b \030\031\002\006\024\r\t\b \017\n\036\027\ \036\027\017\005 \f\235\017\027\022\021\036\030\026 \(\023\036\022)Tj 0 Tc 0 Tw (-)Tj 0.008 Tc 0.471 Tw T* (\021\036\027\024\); \027\026\035\017\004\017\036 \r\t\030\026\032\036\027\ \027\t\b \030\031\002\006\024\r\t\b \017\n\036\027\036)Tj 0 Tc 0 Tw (-)Tj 0.008 Tc 0.375 Tw T* [(\027\017\005 \026\027\026\035\034\027\024\020\024 \022\026\027\026\035\026\ , \r\f\035\036\007\f\021\r\017\036 \023\036\030\036\027\036\f\036\027\027\ \t\b)8.1( )]TJ 0.679 Tw T* [(\030\026\027\036\036 )0.5(\024\023\036\030\026\021\017\r\027\t\b )0.5(\r\n\036\001\026\021\036\035\034\f\021\r; )0.5(\b\030\024\027\017\004\036\f\022\026\016)8( )]TJ 0.194 Tw T* (\026\027\026\035\034\027\026\016 \021\030\036\013\017\027\026 \002\036 \ \f\023\026\n\026 \f\235\017\027\022\021\036\030\026; \023\026\006\017\036\ \027)Tj 0 Tc 0 Tw (-)Tj 0.008 Tc 0.208 Tw T* (\021\t \f)Tj /Span<>> BDC ( )Tj EMC [(\r\024\f\023\026\035\017\021\036\035\034\027\t\n\017 \026\002\024\035\036\ \r\026\027\017\016\n\017 \022\017\001\036\004\027\017\022\026;)8( )]TJ 0.114 Tw T* (\f\024\n\026\021\017\004\036\f\022\017\036 \017)Tj /Span<>> BDC ( )Tj EMC (\023\f\017\b\017\004\036\f\022\017\036 \026\002\024\035\036\r\026\027\017\ \016 \r)Tj /Span<>> BDC ( )Tj EMC [(\f\021\026\007\017\017)8( )]TJ -0.008 Tw 0 -1.218 TD (\007\036\022\024\n\023\036\027\f\026\006\017\017.)Tj /T1_2 1 Tf 0 Tc 0.289 Tw 0 -1.218 TD [(\021\006\t\003\r\006\t\t \t\217\220\f\211\201\r\b\t\235 )0.5(\212\004\204\t\r\b\003\002 \t\213)]TJ /Span<>> BDC ( )Tj EMC (\t\217\217\f\r\240\002\004)Tj 0 Tw (-)Tj T* (\b\t\235: )Tj /T1_1 1 Tf 0.044 Tw 2.176 0 Td (\017\n\036\027\036\027\017\036 \024\002\255\036\n\026 \017)Tj /Span<>> BDC ( )Tj EMC (\b\024\007\026 \024\023\036\030\026\021\017\r\027\024\020\024 \r\n\036\001\ \026)Tj 0 Tw (-)Tj 0.372 Tw -2.176 -1.218 Td (\021\036\035\034\f\021\r\026 \(\017\027\021\030\026\024\023\036\030\026\006\ \017\024\027\027\024\); \027\036\r\t\023\024\035\027\036\027\017\036 \023\ \030\024)Tj 0 Tw (-)Tj T* (\021\024\022\024\035\026 \017\f\f\035\036\007\024\r\026\027\017\016 \023\ \026\006\017\036\027\021\024\n \027\026)Tj /Span<>> BDC ( )Tj EMC (\035\033\002\024\n \036\020\024 \220\021\026\023\036.)Tj 0.17 Tw 0 -1.218 TD [(\200\f\036\n \023\026\006\017\036\027\021\026\n, \r\024\001\036\007\001\017\ \n )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC [(\017\f\f\035\036\007\024\r\026\027\017\036, )0.5(\027\026)]TJ /Span<>> BDC ( )Tj EMC (\007\024)Tj 0 Tw (-)Tj 0.409 Tw 0 -1.218 TD (\024\023\036\030\026\006\017\024\027\027\024\n \220\021\026\023\036 \023\ \030\024\r\024\007\017\035\026\f\034 \023\030\024\235\017\035\024\n\036\021\ \030\017\016 )Tj 0.332 Tw 0 -1.218 TD (\007\035\016 \024\002\255\036\022\021\017\r\027\024\005 \024\006\036\027\ \022\017 \017\f\b\024\007\027\024\020\024 \235\031\027\022\006\017\024\027\ \026\035\034)Tj 0 Tw (-)Tj 0.438 Tw 0 -1.218 TD (\027\024\020\024 \f\024\f\021\024\016\027\017\016 \026\023\017\030\026\021\ \036\035\034\027\024\020\024 \026\023\023\026\030\026\021\026 \023\030\016\ \n\024\005 )Tj 0.244 Tw 0 -1.218 TD (\022\017\001\022\017 \(\003\202\215\025\) \f)Tj /Span<>> BDC ( )Tj EMC (\024\023\030\036\007\036\035\036\027\017\036\n \017)Tj /Span<>> BDC ( )Tj EMC (\024\006\036\027\022\024\005 \004\036\021\t\030\201\b )Tj 0.535 Tw 0 -1.218 TD (\023\026\030\026\n\036\021\030\024\r \r\027\031\021\030\017\026\027\026\035\ \034\027\024\020\024 \007\026\r\035\036\027\017\016: \f\030\036\007\027\036\ \020\024 )Tj 0.301 Tw 0 -1.218 TD (\017)Tj /Span<>> BDC ( )Tj EMC (\n\026\022\f\017\n\026\035\034\027\024\020\024 \r)Tj /Span<>> BDC ( )Tj EMC (\023\024\022\024\036, \f\030\036\007\027\036\020\024 \017)Tj /Span<>> BDC ( )Tj EMC (\n\026\022\f\017\n\026\035\034)Tj 0 Tw (-)Tj 0.147 Tw 0 -1.218 TD (\027\024\020\024)Tj /Span<>> BDC ( )Tj EMC [(\227 )0.5(\023\030\017)]TJ /Span<>> BDC ( )Tj EMC [(\r\024\035\036\r\024\n )0.5(\f\024\022\030\026\013\036\027\017\017. )0.5(\215\024\r\t\001\036\027\017\036 \b\024\021\016 )]TJ 0.048 Tw T* (\002\t \024\007\027\024\020\024 \017)Tj /Span<>> BDC ( )Tj EMC (\023\026\030\026\n\036\021\030\024\r \r\027\031\021\030\017\026\027\026\035\ \034\027\024\020\024 \007\026\r\035\036\027\017\016 )Tj -0.024 Tw 0 -1.218 TD (\r)Tj /Span<>> BDC ( )Tj EMC (\023\024\022\024\036 \007\036\n\024\027\f\021\030\017\030\024\r\026\035\024\ \027\026\035\017\004\017\036 \f\023\026\n\026 \200\202\221. \230\026\022\ \032\036 )Tj 0.276 Tw 0 -1.218 TD (\r\f\036 \023\026\006\017\036\027\021\t \023\030\024\b\024\007\017\035\017\ \026\027\022\036\021\017\030\024\r\026\027\017\036 \023\024)Tj /Span<>> BDC ( )Tj EMC (\001\022\026\035\036 )Tj -0.002 Tw 0 -1.218 TD [(\017\027\022\024\027\021\017\027\036\027\006\017\017 W)22(e)-18(xner \017)]TJ /Span<>> BDC ( )Tj EMC (\r\017\031\026\035\034\027\024-\026\027\026\035\024\020\024\r\024\005 \001\ \022\026)Tj 0 Tw (-)Tj 0.174 Tw T* (\035\036 \002\024\035\017 \(\200\202\234\) \007\035\016 \017\f\b\024\007\ \027\024\005 \024\006\036\027\022\017 \f\031\002\255\036\022\021\017\r\027\ \t\b )Tj 0.063 Tw T* [(\023\030\017\027\026\022\024\r \027\036\007\036\030\032\026\027\017\016\ )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC (\031\030\024\r\027\016 \002\024\035\036\r\024\020\024 \f\017\027\007\030\ \024\n\026 )Tj 0.055 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC (\007\024\024\023\036\030\026\006\017\024\027\027\024\n \220\021\026\023\036\ . \215\024\f\035\036 \023\030\024\r\036\007\036\027\027\024\020\024 \024\ \023\036)Tj 0 Tw (-)Tj 0.224 Tw T* (\030\026\021\017\r\027\024\020\024 \r\n\036\001\026\021\036\035\034\f\021\ \r\026 \r)Tj /Span<>> BDC ( )Tj EMC (\021\036\004\036\027\017\036 \r\f\036\020\024 \023\036\030\017\024\007\026\ )Tj -0.021 Tw T* (\027\026\b\024\032\007\036\027\017\016 \r)Tj /Span<>> BDC ( )Tj EMC (\f\021\026\006\017\024\027\026\030\036 \023\026\006\017\036\027\021\026\n\ \036\032\036\007\027\036\r\027\024 \023\030\024)Tj 0 Tw (-)Tj 0.403 Tw T* (\r\024\007\017\035\f\016 \024\f\n\024\021\030, \023\026\035\034\006\036\r\ \024\036 \017\f\f\035\036\007\024\r\026\027\017\036 \023\030\016\n\024\005\ )Tj 0.374 Tw T* (\022\017\001\022\017 \007\035\016 \024\006\036\027\022\017 \f\024\f\021\024\ \016\027\017\016 \023\024\f\035\036\024\023\036\030\026\006\017\024\027\027\ \t\b )Tj 0.135 Tw T* (\030\026\027 \017)Tj /Span<>> BDC ( )Tj EMC (\027\026 \023\030\036\007\n\036\021 \030\026\r\017\021\017\016 \r\024\n\ \024\032\027\t\b \024\f\035\024\032\027\036\027\017\005 )Tj 0.336 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\030\026\027\027\036\n \023\024\f\035\036\024\023\036\030\026\006\017\024\ \027\027\024\n \023\036\030\017\024\007\036, \024\006\036\027\017\r\026\035\ )Tj 0 Tw (-)Tj 0.158 Tw T* (\f\016 \031\030\024\r\036\027\034 \002\024\035\036\r\024\020\024 \f\017\027\ \007\030\024\n\026 \023\024)Tj /Span<>> BDC ( )Tj EMC (\001\022\026\035\036 \200\202\234 \007\024)Tj /Span<>> BDC ( )Tj EMC (7 )Tj 0.379 Tw T* (\007\027\016 \023\024\f\035\036\024\023\036\030\026\006\017\024\027\027\024\ \020\024 \023\036\030\017\024\007\026, \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\r\024\007\017\035\026\f\034 )Tj 0.168 Tw T* (\022\024\027\021\030\024\035\034\027\026\016 \023\030\024\235\017\035\024\ \n\036\021\030\017\016 \027\026)Tj /Span<>> BDC ( )Tj EMC (7 \f\031\021\022\017 \023\024\f\035\036 \024\023\036)Tj 0 Tw (-)Tj 0.115 Tw T* (\030\026\006\017\017. \212\035\016 \024\006\036\027\022\017 \026\032\017\ \r\035\036\027\017\016 \023\024\f\035\036\024\023\036\030\026\006\017\024\ \027\027\t\b )Tj 0.003 Tw T* [(\030\026\027, \004\026\f\021\024\021\t \r\024\027\017\022\027\024\r\036\ \027\017\016 )0.5(\030\036\006\017\007\017\r\024\r \026\002\024\035\036\r\026\027\017\016\ , )]TJ 0.282 Tw T* (\023\024\f\035\036\024\023\036\030\026\006\017\024\027\027\t\b \024\f\035\ \024\032\027\036\027\017\005, \235\031\027\022\006\017\024\027\026\035\034\ \027\024\020\024 )Tj 0.028 Tw T* [(\f\024\f\021\024\016\027\017\016 \003\202\215\025 \023\026\006\017\036\027\ \021\026\n )0.5(\023\030\024\r\024\007\017\035\f\016 \022\024\027\021\030\024\035\034\027\ \t\005 )]TJ 0.07 Tw T* (\024\f\n\024\021\030, \026\027\022\036\021\017\030\024\r\026\027\017\036\ \023\024)Tj /Span<>> BDC ( )Tj EMC [(\001\022\026\035\036 W)22(e)-18(xner \017)]TJ /Span<>> BDC ( )Tj EMC (\023\030\024\235\017\035\024)Tj 0 Tw (-)Tj T* (\n\036\021\030\017\016 \027\026)Tj /Span<>> BDC ( )Tj EMC (45 \f\031\021\022\017 \023\024\f\035\036 \024\023\036\030\026\006\017\017\ .)Tj 0.545 Tw T* [(\215\026\006\017\036\027\021\t \f\030\026\r\027\017\r\026\036\n\t\b )0.5(\020\030\031\023\023 \002\t\035\017 \f\024\023\024\f\021\026\r\017)]TJ 0 Tw (-)Tj 0.608 Tw 0 -1.218 TD (\n\t \023\024)Tj /Span<>> BDC ( )Tj EMC (\024\f\027\024\r\027\t\n \022\035\017\027\017\004\036\f\022\017\n \b\026\ \030\026\022\021\036\030\017\f\021\017\022\026\n )Tj 0 Tw 0 -1.218 TD (\(\230\026\002\035.)Tj /Span<>> BDC ( )Tj EMC (1,2\).)Tj 0.004 Tc 0.108 Tw 0 -1.218 TD (\215\030\017 \f\030\026\r\027\017\021\036\035\034\027\024\005 \024\006\036\ \027\022\036 \022\035\017\027\017\004\036\f\022\017\b \b\026\030\026\022\ \021\036\030\017)Tj 0 Tc 0 Tw (-)Tj 0.004 Tc -0.035 Tw T* [(\f\021\017\022 )0.5(\023\026\006\017\036\027\021\024\r \r)]TJ /Span<>> BDC ( )Tj EMC 7.252 0 Td [(\020\030\031\023\023\026\b )0.5(\017\f\f\035\036\007\024\r\026\027\017\016 )0.5(\030\024\007\t )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 12.482 0 Td (\026\027\026\n)Tj 0 Tc 0 Tw (-)Tj 0.004 Tc 0.182 Tw -19.734 -1.218 Td (\027\036\036 \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\022 \002\t\035\017 \027\036\024\f\035\024\ \032\027\036\027\027\t\036, \026)Tj /Span<>> BDC ( )Tj EMC [(\027\026\035\017\004\017\036)4( )]TJ 0.355 Tw 0 -1.218 TD [(\b\024\021\016 \002\t \024\007\027\024\020\024 \023\036\030\017\024\007\017\ \004\036\f\022\017 \027\036\r\023\030\026\r\035\016\033\013\036\020\024\f\ \016)4( )]TJ 0.134 Tw 0 -1.218 TD [(\r\027\031\021\030\036\027\027\036\020\024 )0.6(\020\036\n\024\030\030\024\017\007\026\035\034\027\024\020\024 )0.5(\031\035\026 )0.5(\030\026\f\006\036\027\017\r\026\035\024\f\034)4( )]TJ 0.111 Tw 0 -1.218 TD (\027\026\n\017, \022\026\022 \020\036\n\024\030\030\024\005 4 \f\021\026\ \007\017\017, \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\n \027\017 \031)Tj /Span<>> BDC ( )Tj EMC [(\024\007\027\024\020\024)4( )]TJ 0.223 Tw 0 -1.218 TD (\017)Tj /Span<>> BDC ( )Tj EMC 1.412 0 Td [(\023\026\006\017\036\027\021\024\r )0.5(\027\036 )0.5(\027\026\002\035\033\007\026\035\024\f\034 )0.5(\023\024\f\021\024\016\027\027\024\020\024 )0.5(\006\017\030\022\031)]TJ 0 Tc 0 Tw (-)Tj 0.004 Tc 0.419 Tw -1.412 -1.218 Td [(\035\016\030\027\024\020\024 )0.5(\r\t\023\026\007\036\027\017\016 )0.5(\r\027\031\021\030\036\027\027\017\b )0.5(\020\036\n\024\030\030\024\017\007\026\035\034\027\t\b)4( )]TJ -0.004 Tw 0 -1.218 TD (\031\035\024\r.)Tj ET q /GS0 gs 168.4800207 0 0 264.9579915 70.8661495 101.018152 cm /Im0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0 Tc 0 Tw 9 0 0 9 70.8661 90.1959 Tm (\022\t\217\210\b\002\220 1.)Tj 0 0 0 1 k /GS1 gs /T1_3 1 Tf ( \200\025\016\026\017\021 \025\t\t\023\031\030\n\027\026\021\025\002)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0 -1.2 TD [(F)-16(igure 1)47.1(.)]TJ 0 0 0 1 k /GS1 gs /T1_3 1 Tf [( S)28(tudy design)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\033\030\031\030\213\b)-20.9(\035\231\213\233\t \021\032)50(\b)42(\032\231\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj -51.938 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 23, \023\0221)69(, 202)69(4)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 23, \023\0221)69(, 202)69(4)]TJ /T1_5 1 Tf 25 0 0 25 28.2777 56.0378 Tm (44)Tj ET endstream endobj 2186 0 obj <>stream AdobedC     '$''''$25552;;;;;;;;;;, (`  u!1A"QU#23STVaq$eBR %&'()*456789:CDEFGHIJWXYZbcdfghijrstuvwxyz?jE e?r\Yq-p*8)zx#Mhx#Mk?ٽ\x#Mhx#Mhx#Mhx#Mhx#Mk?ٽ\x#Mk?ٽ\x#Mhx#Mhx#Mk?ٽ\x#Mhx#Mhx#Mk?ٽ\?ٽ\?ٽ\x#Mk?ٽ\?ٽ\?ٽ\x#Mk?ٽ\?ٽ\x#Mhx#Mhx#Mk?ٽ\?ٽr_s^<5lޮ_s^<Λ0_q]'x~1s4} CZcvᨓjEZ/RVZ(kۡ;9m8AZJ8p8+msweۧooh`oHK|jjJKe` ܸR )C#&2 Ɠ'(2c p[沑9XGUuoQINxr QIyO '?^1 CNO6sYIZBBy bۭM,re$uXL~>*Iyk"AZJNzqRB2H}`eF˨89RFX(9uRy˛Ik-=I':KEZ$íW{y#cŝ+:Yh֦ƒiQƲٔ3,Н̀.6.!%8KJ@z[3m 1N.Kae2ҍSQKG'E]mHqM4B`$p)O&ͷmRk'ue HJ 8\Y=vnܣقB[ [n%I%yO?^oQ:,<6*XR#9n/J7_Ӝr`Vݤby!ѺCS:Ke*IBPqo2yen$|*0iN6))s5+ ʍz&M7F;HҔ' ֞C$eDbnZݻISJLgP* ƞJNNys]6SF3[sԕ.1SuJwNH) <!%{zĥ(qK-DNy1S{iN"f>) ZJPWVgM@*Joeԧ&C~H*JR4ux<21ƴdl`bI|xP:JA(w[>GgꟌ߼#nt6J+S<- E֬k @$c}֣6ё\wFABB¸ѣ83a-J56˄ 7HҁXty=hp:䝕eO\$6BrH< %nHBa*F yY q&;VjjEZe\QEQEx@P)P#"() 8E{Ey (ml2k/y.*FAHIHT+(ǼkQ^EWQj(>?0o՚jEZ/RVZ(.ZK %)'H'Hp[Z%TpT# ׭Wex_jf?0o՚jEZ/RVZ(%WY] շߘɕjУ#vNpOkg6m2-0ܽ[vCLiIK;8R $ oNǕ$Z޹y+Jst4#RI Y<8V-R? 5ejQgdHR&UfJ"آmhKcIԒBX`jU$!PUBt+dZ^b{Yac-e Q$ 5dW26f<ӻKGZ(AP@ΐUS]lG& )&ѹ[E@ԐTTjD&1HR-BZBZR@ € ?ej%'T J 4 50k$͎: - t9 `'KE7ISg-"JQ J@bF5p{NA(g+[j90:'bir|n mzxm5p}9وy)hK BGɌs[6n.%-- W"?Ugl+&.Å@:[$)yR+tmjj&"Sʷ7)ԡXl$$ HH9I,~Np2CXB[IR0qQv-Ȝfw02|nh*NAɫ-QUN7ԇj@jEZ/RVZ(C;ҽ' AV=F|ތթ:sq&;)CR@uh2 ̈́(+Rt5xo@8ש:sqrcpIp$uG*$pKH '?YN[KJӜe$(gPZZ*R?0o՚jEZ/RVZ(j{)Lu,ZN,;oK`g̨{M6\,r!2:(k:JxT‘d!!m8َӁR(% AqVOqOb4쭵\u!RTn@y9˴M~0--d! yO+cڞAbKb4CJPz$Y5-sí\]}!T-Di{R\z,$lǼ6x`J%D%(Z HQ@<@ 0 ܬ4-hv (RZm@ Pxtd3z⶚7,!CqɞL}OB-BSDEsRto ow36-I{*3) b3%%Iq-᱐9qjG},7%KW&REY9}MHvjEZ/RVZ( Z1y^EWh1^r,7yr|)eMƄ ӞRO/)$vN_CϙR gvJR 'ԍy򽢊ׅ* )IΕc.>F*HMeX:o]'$dusVIJRR`WQUN7ԇj@jEZ/RVZܮ͎Ҧ7%N%!%+A$|Nx\J_Irō2r2VVZH-+DMߛf [6')S-'Jѥ#vr'ZմW骱Ȁx_ۑqD>8w]T7^~ސu 2~ i*W_LC*[a =njBRAЧN5{Gv=u-[nTV[Syv5-ȭ\Y(Q[njZZQ;ޠ+((e$=NF%\[:ZC:Q9歱hCem .ZЧ%Z {f$YTQӐ#isDM3i~T3rb><\Jq>_Tc8;6Ml6w,gCqTHN58ViirŔž7$)9н!:͞z/QT_ÏKmL:.WrqhirYZ-!zy ﲬc<$Y7oE 7'~!ЧO&ڋ)Hy XRaLI /' X´mm.DVFuI%n%(LJ#<[EiE3ʊ0p^춥\AOǭ[~әcq-1lKҚ/<(ǧk˱u&Nm4#[Iou$9jn=rcoۼ+LQXA91\[-ӡ8d]3T\iA: q:RB +km؄ mn >ZT\R Ju hmHusܕZջ^:ROmmr SS ͠){\X[JRUy%n6v2ł]mK-6Q N0NjvۂQ!CMuOKPo$:!!@ g<3^-ץ4e5pu:̕hQ !%IV~usV6ЗdG(ȊCaE/h'Z\u ׌<hZxD}ĴIiN)ЬF`g96:>![(amU+[Ht\՚>?0o՚jEZ/RVZX-^aŰu )!H V1k r;`-)$Tk-h}m8b 1SLyR)sRn)xZB8^j+d-3dJ%R'-k|˛#IHR9oNڑt] q/:uîp  zpegƟ2:.&JY[+iI0Ьm5m!A -4Ng ۣ@jòPy=V/<ʉ^-@R6[jq*Z֢)k<<*Ne\BĘme ')SҭVoZU:]Tf t4HIˆnjcbmqdjuQ!^&]OQybES$ɔ!\h[ĖTxȭ8P\LKy^9hX99Ԝktx>7cV)WIQ'9< [rTHϵ;-.e[ 5\{/ i$55j j8taDpj썲6\_B|**V8pn;ׅШi^ƞN*al-'|QChZ\<Ԑklt҄WL:\UԎ<-l^yǥjxxcz=z؝ڟm )m!Rw`'jڭZ8ҘЭQd5:Osq٨79{C:eT(IZ{aڡ 2Pi-5H!CP(΄W0+-j&t!׍ŠԄ8e)9FHk S NI!/BO dluRfe(\\m#~{'crޒe/rXBl( cXZdI1ISZʛ %:SȜ$1R5Y9}MHvjEZ/RVZ(((|ﾭXm>;<]c͒VPT0yxXaMaLXC <IÒvgfwfpmwj95 oz[h8z4.dmrs n_:ˉ s2#5jl#%ťť)QTry ݝe6䄡LN%*X_#'V +s (8,ćȜgV^-I-Șy#NWy8Uvf  9*.'|9y} {O͇:Dwo@BpqN](\ "SJÉd(o ( 9(((>?0o՚jEZ/RVZ((()}nޕy Ĕn.QjJDV{P!Ae= 3^X;<պJT֣9s<3mOn;yd%iCJUQ]WǘÖ [U%IszAPA*Bxg\LUQ3։1mʕ% >8䨷,w =n.4D8emIBu;ĂNA}w e;l ,5 YaRQyYMpBr[[B/BB@lB q+͖1SMڐRBIr)juJPq)CTeۖAw}bJ`3I|qjg_Diiu.oI#yM\՝x%T&]!(-d2p\{8w=9SXԘC6x1 n((*s 8YjEZ/RVZ((((({E{EQEQEUgq7!ڳPjE}ٸw"!1˱87%]P WH3y=:Fٛo9Q3#1ٛo9Q4~{yb緜(?fo=GHvf{tfo=GH3y=:Fٛo9Q3#1ٛo9Q4~{yb緜({yb緜({yb$Yw%K^f-ns?f/=GHvf{tfo=GH3y=:Fc7sأf;3y=:Fٛo9Q3#G緜(?fo=GHvf{t7sأf;3y=:Fc7sأh#G緜({yb^{ybxsVEje굸J֧*5@jEQEQEQEQEQED_fb((((jEQEQEQEQEQERq0"$ݪf HsUŗPH}8$28tQEQEQEQEQ@jEQEDbGvThi8JR'Uxx#li q+׾]y]j.yĮGc}bWyڋo>+E7XhwϬJ4{Qv;%w=]y]j.yĮGc}bWyڋo>+מ]y][@^6B\$jg: Qv;wڋo>+E7XhwϬJ4{Qv;%w=]y]j.yĮGc}bWyڋo>+E7XhwϬJ4{Qv;%w#lhnbPxyMYh(jEQE0/͗?hRtQEQEQEQEQEQEQUo2+%QEjEQE0/?hRtQEQTwݝuI%ۍVz 8p~rb}tҙRT-$C*ʴsmmMXd:n-LLN#%(*V Gus,q))L`KhyL: %GÒ.ҠKZ֠5@e:ohEJ1Ӎt8_emF}l95a\p`-a.`'#6V.kTnoI%Z1ջm6h(~0eV?O5VJ((jEQE0/?hRtQEQQ-ݦG0<^u0yUdVW%vRT\qZZI$e Irgd,ay|Xݾ `18V*?5X)Q*BB\pj #O^#&^["_EްZp(85ǔV ע1yIHuЕऺ:* 9*)+ " BeDGPB7 K`1f7!2iHeҜƧyC :y4tǵ^u1Wgn'uGL{UYۉQywTtǵ^u1Wgn'uGL{UYۉQywTtǵ^u1Wgn'uGL{UYۉTfM8 J.!gP-^h(jEQEQEQEsK۠gJf0<}Q=(8uIϭIB1UyHBڒ9> su-@0dܘ98R[p[٨`ϓ.qH}=uDZ`peChBBV3k+M-{2\';32p{\.0m ȐD6[Ku>LlÞG=VڝI>bR⭩)kHDr'˩BO5(̾u2$DdVtQEQEQEPjznl ue:JJ5ډ?ڒM<ԕިlvGf~+%w=3y]+QDٟI]j&WjJT{Q6gRWzډ?ڒM<ԕު~ Ws[ۢhq Ξ<rM9Af\v,DL= y "_Fj,>fG]+QDٟI]j&WjJUlK{vn;%jm!ARVh*L.-ڄ ^!V\:;ztk#V*,i^T1?N[.-Nר(q\6LEgwOX96Ё*yIWmׄD9ĀOnWtq쌯k{KI)>UPִޝzdw:tw뵑ߨ;׮G~G|^Yzdw:tw뵑ߨ;׮G~G|^Yzdw[jFLdpS6kd{T oZ`d8$sujke~_;KG醪EQ^d+WB)'}{#h2>7g~ͮ5Vj(1~":l-dCZƢ3Xz4ScHhSN5'@ȭLm&Iu Fu!W]f3e@$I<lo)/ܡ%֊ A IʲGΖ$\4q-撡<½N)|Bu !*$ Cʌ:[C`tǒĦ$$x a6|s=pVZZFT@ U:%Lv\BVFF ۍ]iAhZBRAҟYi+qd! rN$JHe*q $Y2RC-.4B' V2Y$5Z~GJjke~_;KG醪Uݮ)-VgA[RR~Uw`lmp3qBI jQJQZ6jo7yjI}F=df546N*cj&oGjKE3դ:aZ=gԅ0ݲKe<[2ۊHXN #;tv6.m٩O?%c2[oypZdPӏ<ӈK6ʝHV [r];Z]yCJV:[W oN,B*BֵQ!hm䨨db8U7Got^5 ׯwgyYኩ;ywZqςT- pkRr#zT[nQʝkIjUԶߔn҆Ԁ ᕞaH'kGBR;cD,6@s@SK73L-]JH/+ TiN00:d:VtLq=Z> n5?UufO5QEV]RVj"cwOD_|>>īn졋NUA,2xI9' paaBJ\J.3Hm:uNJm(B=BE@L:v˄>Tx)+ãrr.G)95#mԽ!J'I y$$Bnkf*!_ ƈcj :4 Blj)gF k.B tT H*JndwV%$i&tot7GnwFǧƠvta\ jֶACZ%'#:6DMܖPU!@)ja"f>[{i8$|;I j ҕ@jke~_;KG醪\;\+^h JФhP @\z32:Dd!+,(%ʢ k&ϱb2Ly2跔B]WXrp3[/xn6Rs q|d`ε.L!A- kox lTMJ OZQ

5i!,#rjB].DPAR<H .fȕcMm-cŷ ,8*'5OGt:K—Va!:Pq׭-ppuSJK8F F/'-gk0ks{\}cƅ9uJh@C9JW8<ZY1ÌT:҂m⢠RBq#lGҜy._} $pjxwCUf(˿3?ڼB*\VˢRFePm\jPhI:Bh4'#0-Eh 8H<+Uܙ% IqqJFFResz^UpY^ἕrKg3Ϡ`97hg|v3¼dۜ[ njP4*I9 FhdA|Ʌo({'GG?/}>J?^{QOfײ~^4|~٣쟗%dk.~|%iHqǗĎk쟗%dh({'GG?/}>J?^{QOfײ~^4|~٭QlU+h^o5)DkV!Lq J>BNVؒ->\l*Bdd(8zEQEQ@jEQEr]n[e\Aqq!8BT@ 6vH}BV#`@|k./vg^UMk [HZt)QEy&1տ睙E\hfEt|?":hyٟ{4_<Ƚ/vg^GM;3r/}睙E\hfEt|?":hyٟ{4_<Ƚ/vg^GM;3r/}睙E\hfEt|?":hyٟ{4_<Ƚ;Yh=t^Mm1L$%#rjiIHJvbp\\9fEﵢ^O$,c1m:)IqA Η P]QEPjEQECm'xF6mfQMmd$Rxr  T섬 I'(#UQEQEQEQEQEQU_Yﳨ? U((jEQEC'xF6mfQMwPw05n`4JP)3pXZҭ$p49.S!yʴ̘e3-eVԜgڏ2S$-ml!xd)%ENRǎzޅC&Tk2^{h&EX7 ,F%%{iB}:C;6LIS$4e/nu-*!zx:Ƴ\8Ů,mܩSX[%I^gXʜZ;3y7g@a*ygr5<(}[8NъܺLlhV<<+2N?1ЮvB$b egQu̬=<.[GG2h(V}m[ϭؠm``h*)|e#-PNz^N1T2h(V}m[ϭأY{x]o+>b egQu̬=<.[GG2h(V}m[ϭأY{x]o+>bx Aݣخ((jEQEQEQEQEQQ,r0OLj(((((jEQEQEQEQEW88 X]ZR%{aZ΁)EQEQEQEQEQ@jEBmuҙ6ԴK8t'\<&wThG/ѣlgwF-<&wthG/ѣlgwF-<&wthG/ѣlgwF-<&wthG/ѣlgwF-<&wthG/K[+LJڬkTtK1Vs9m[e;4x#mL_Q3G?}D[e;4x#mL_Q3G?}D[e;4x#mL_Q3G?}D[e;4x#mL_Q3G?}D[e;4x#mLv]npB?D[e>Ķz( jEV-n>Vf3+!iiV)$yFiN$Dw^eXuG!kHJ̓ǚf$f$'HpheC )D 0rH#Ck+3^ׄ⽯{^WsŴez5% Kh[)J JO?ƴ//aރiCyXPR0wRdq4fў8״Q^d|%Q^וy^ke_{MoUejEV-n>&e޶zMn֖tli%mE6HPeŒ\ʚf0miZXJ'>Fδ\FLyn\aeE$$u xɞ2ݿ>ILM#ɌVrjF2s\-ў ղP}6BI)It%ݩʁ"Sf!Ў+ZtiNA9ZUWk4 Ɍ&qjz4mDP) kp+mnDŅMPꘐΕu^5ҥi( = T}t.C-:~ J+W%j~9]i|Ę i2N: \+n*N҄[䆣jf@:`<&=W;xyvH^m R@ -`O/S; L92KLʉ@g7.$!K V,<3y9ySQm8;G!ct&VFQǓqZ f< u;R̀ɏ$-0*Rtj u[.V)M[=xr@[i(ޔa >EXvz"ګâ+![ҒJ ǔU[-o-jEV-n>EQ^5h((08rc b((.hwQqwv۩u!\cAԒt)$Bt #$Q*Q$ʼq׵G^|(醪EjEV-n>y7]$18Ps$r:=vaי )iR%+r@5]w>zfPRBp1Li&Dj=*SH֕a@Nycäʭ"*FW~KN5VL]wVQԗJƔ4rVF^%4%-TuRgWy9:i{{^9++2U+~mٟ{wi!  |=&KKqR)㭶JwJX^zJm pӯzLqǯ]s6`lrV#K J OZM2ĦyL&㥔:[Kz Z$fFb4m$4ӍH:wmKJAc[t#4ٗto:  <H9bޫb'V;e;!6z P<*j>qT7$V$Iҭ' jreZ &)C4 Xx]qI ݉"HݨMVVNTx$ '8t¸m-,KNĨ.2j^8E7hn-$&:Bֹg 88q ydGaRPA} C><06B vRR +r㖴]6jb3mp%U jJPIyZ"[;/).n)Klﲢ gWkcQbE[-*}88- 8WKM -Zr)N]N@Qv"P-1!6UR,ap̰ q*;E)qFR'-hJtB(vVTE x=gkڛ&:b^4pۡ+ZIs\vʹܧ DH5 dXZ. 8w $k{{q1]mۃ5)Rx2evt} +-Nt QPWyRy\LuTSp$qox7`j) '-o-jEV-n>Rmj|pi6jZ2RP Ȓ#ȕ)nKqȔTD,1Ťgs$8JGwCM\KqKmZZJ@@F9k\]q|֌8VQ̫@[]g”"j,+NaY>x[4JŐ!7)R TI$y}*֓n6Ɯq)6] {ΥXP*$ DeۑDy3dDWZƨZT(9i$9S\{'o7jĨhu Z[:H^x+ N8 cb-]KKiIC4I|:⊚Q+*:O((wb-$"KooЦ.*tUx g C)nrSODiRDW]F0:F@PEhpez, L hH SgIBJ+2p\o}0YhjEV-n>ט68T(I<y-s)o0e>&k̞'8ׂe:1p
k $: Uo5\b(ƀDp8שYWD<ԡ=W+/ )Rf uJJo*RN5q #[bσ8)Pd5%(8Yeht$qYI&DPIƧR[@\ZWu6rdt%4: Jx$ލ{{_ի3^wep#YBm*ӍZT15ove҉^8h%g:zm͎QKKSI8!$n)qܒt6D*=`=x ^]c5D/W2Tq_ ]rCu3q!HF8D'=ci9-)*(iP*'k+ne{x΍ZʚԦW\Bʁ>rhi:2{;TimzytËH&b{է>k C A J ASw3#]o ,n@J5U+rɻ͡ՖڝkJ )y($ EX 㞵x͡gDyt%^;dmƐӫkĶ-I& ǻhe ̎8yĺCgfKm> ӡ¿s͊I\&䲹-Gr9zՌ،V Hy$F QxÒl3u4jPV/9^jCI}2C$ΊliҍjPjEV-n>X:i*JRIJRV} ]l3O+z2pNpB[leEse2 Ã1ExI(JUc 8r*uO&.픃H׺l:&q\u6k,hQ$ř}euAwv xq<*o9g~޸G lmK JP*NyO%vl"8Ԉ3oR*:ҙ啯PI !@g f&hMCH.e *Ixmܵ)߅'͗:a\ljJK^BH"-exWjqӗ'×I_u*m#mj- n KJRSH#'%G9nӳQ}q mWtk@BPRF`s]wh.0-]CIB"{앪7T4!%D+XW 9:-2wp)uӏwP ]ѓ,޷V1^lSZ 8'W'Udf{d 0ԗ\uK!9ʀy)f,WxحtuPPp)D(1"anS)SlKM68% ɋ}*~`_VɌZDr5i#Us F[P$,q;6RIoQM]{A a.MĒ˨yMTRIԔi8s]ɹn9bJ3PU0TapR9 n6g^AHbt[+TΧBRRUcQV8ukDYK]X6*~U@EtMNZKv~~=RZAuwP``sW$ODϴҟfn-#x Hz NΪ#q߸CC:upJǖOb[_;>7*:Qޑ3r\G5oDf蒝l02qi.(u'F#sp+;W|oY\PM5sKu/_j9M I >L[IR8C y͈obƾL8KruKe N Fy*ŲP_ңGqzDHK Ou(iOQU}7Q UjEV-n>EQEm•-!E ԂFpy2+:+) J! Sb˂ {BH P@&޵5)=:*JPB\+)(IZJR $$ؔ_i|Rj A QEx@EWIjK[`x+i^g[ tr5MhbzZ ^`(7R+^[ˏpmfa$ܶ (QJV֭.W- aݴۺžl5mDed\%[qq%!.%ƀ@)ʹ*omZfn[JWH@[[̄dpԄuo^6xň d[ yKYHPXZZ"lw˱%Nka)(Y)s98W;ۋSsYBKJm@)$gEWflVԌB4x|ZuOD_T;k$l϶)2%:}!.80!C$p<ⲏ(3 d R8pi=Q@p:R QSWNTΒtt6eTV!Xv=¹c콚<%v:JXSȓ`q[cXm-yAy(<~ ӜNl}(*0L)\ FOYt&P\/MRPfoeѕnL :㌍(IlC56oJ6Z)JZ - p98rU~*&.FtrJJТez8mT|4˥ԕ$XsY'd2nLFbS%.8ÛoR`QԬj'f69v>FKېLYABIWԒJƥ6ڙЭ&Rt=|g#g,D2q$FP\( '#xX{$d-R\`vۇ+CYpy1^'er+Xr:2!QOU9+8;7er *Z}ҵ)@┕} f.,;m^aԍN]5efaˌS 5)=)@ X^IAЬ yj\d^dN0SÈbxh)EQEQEQEQEQ@jEQEQEQEQEQKk3iur"&L6N]2:C^ $ $˃֯h((((jEAiEHDfE:yĶI?@em~vsQ;}[j9ߨ쭿tvVڎw:o+oG;ݕQG@em~vsQ;}[j9ߨ쭿tvVڎw:o+oG;ݕQG@em~vsTET}ͤ0mR%Lp3X85RHTW;@pEKv>VZu(Ⱅ'PH psEbn*ck9RBNp*Rh[6:%o.!Jm)*5]Nt1 C%ZyHVd.% Q JIՀI {ntu".:!AMg=OWό,+V Y*fD4:8iKE\xj<(veaM%  u\Am-\,A/6Sq=PYcr3qPCУȕp t"dG"so6۲* k@*1\MqM%E K͒8OUǏ56KbJeXVq Z887{-댐T[Zhⵔ)p>pMږ@Ji싫hr6 ޷k:km&ϥ*RQ% <:Je#8pjC!HP2 G9~ QC[%IP8 <ˬvHJBBTW)Y9zSpdKe/y+q uYIɭ&ϱ!Q^Dm/vaayƒ ] ۗ4ۓ%-)*1Ӿr9uQEUke_{MoUejEV-n>EUh|4mk\$ԄnԤg<[M#a-KY 㯴YHJ2Ud6kX l2d6 h4MAYV(]v!.]ڠku!-ܔƤj's\췉ʃ;{4H|C%yMj U<#]\];N%DhBPpw Re<)$&n7kz1l4D)*NB}[]͝$_-eҧLt} $(8k!.'LoQッrVVwfX)v-cϸ hm ;jծ薈Swqo;gq-mI6 P3&HXmFz:2ɌY+FˁN=-yLIuj8p:`Rz׳۴{ͲlO2E撆-)@ ADMKmM5O[ݎźC-uP քFR6-й66VH-6+qJB*-Kc.K aNʉ8Vu%LbJ7iyƋm&QKNXz,NpZ796w-^p:WRPQ'=c*x6k5F)cl)La#9xէg^<Êq:|P) `+Ɯ vNVK3Tm-8iZO>zr\_M ;$ .P$jN83- jI.4'I`n[m u$H$9V7$NYh4 iJq@(rz5-l!KS%7-O)p$]*/J7a@jEV-n>EQEWpy:RI H88h(-{EWQEQU}7Q UjEV-n>EQPKxbkSLGeЧP% @JV$q99._nmQ*4EMd\+(!sz56ߤBӦr2–74)*%C$ƺ}ډrmh2fA}+{v B9]kl`WE)) !ą+98N9mh+WZv'&dfJpC$qo1x{s;ZbG}{ĩkGVr/A\~"Ց3Ha:B򟖃ԍ'ЩFصm -VJ޵#ZS x5vXJGG]q>riqՐ6TGJDڛl̥.֕0 BUÏ-dS7FZYԭ(P^iR<:s-W-5-.d*:՛ݠh] %˥[jZ| 'Q(Mi6R]^N50^gЩm͹DDS^g!B $8Zu6 qO4p ]kǣQi#?xÖ0^I(e/-N-GHPk|+feQ?>S[#Jw͑?!'l;~ ه" Sqd(:'QQ$_:芏m1:1--u./AGpk\+2DH^ݺӼ ȣ'ҭ 5*8evt԰oHRW0SumaV\z:ҳ%ġHC}JJN@嬑7CPk BJ{z^!stQEUke_{MoUejEV-n>EQQ+,;uN3"6,R#'Aq?C y[unG9ԥg5;gDB yiڝ9p%i‰$\32]gBǐ;9 *S/xe$Iϣ]62!-4Rv,Cn$,gEQ\R/Vz LZS)sBB`[AcLDO3,RrqoE.c F7;y4Ro}Q#Gy%Me9Q[d5Ih{ƚ֝ӍZ31ƴh,ku "|e8ŖARgۼ]F0JA'3zrqM@J҂B8`ѯ'zKwf.u :SOæ]'w޷7sY98쑖PTHJnBpZV#㈭B͟SN:,$CBS!wih!eTEjg[f^vt#Ju!+)$hyxƅ1ûBנ 9ƽL:ۏoJ>pv (LMyBCCHߴu:sv)R<"oh2Цy6RR mAc2T.HS|8jkt+D -I+Czǩ8'(*/J7a@jEV-n>EQU3Hf3ݦ[NB\RutrH-$ڞ-/dDK[RJy9kۦ¸0n-cu$##Fǟ*<;Bl! ^qiJ3XsDs!76d!ӸBZh  ӭ..U4&l<)Cfc{EQEy^^sрyk(29+(m&[Qn9 tю|c-w^WQ\oIPTAoǂ8LJ! 2 p #5m%KHQAԒ@$LYEQU}7Q UjEV-n>E8<1T{e.{lkƸ@2l6*N++ֻ%h.OX[~\>,$a%Il( q,GwۦTU"LŰ,#Ѕ:KeOP:vd=T /<֭CDh(QIרċН]wf,( |#ϣE\\CHjirRgKXmW OQ$d,<@MĶk|AHNx199MV8qϳ-![[$+92+8̨B3DsXMMmAH, ӌqb[[?$Ȑ,JbQT-$,oÉc|\[ͺʏ!ԆYr9ɏK_z /iM(I,+Cƭ6.-:.ζfNc/ƒ21sUj IN]-W NlѐFF'r3hoŵ_'[W;@n(ov㍤A!iѕj$ 9SظY)qE3QI]@JQ B0V4'ANj'n& *D|8ݥY* g5ma҅DZ‚%xՂTxq [,>|F*NwSrp8<lψ"/:Ӽ}><|Ґm2dJ!Зea9Ht)pRhVElq[Ŷr:#g5ݘ=܈oBF((Ѝh! ʵ0jII`JelKJ 4o3V9sƼgdz>s#]San V5(u|k!EQEQEq.:6TiCd!* gq^X莈q:ҙЅ)'[)<~jY$ Z% Bo^5cZS' r zYfKZL$$ݎh#RTPqǚ,_ml N$KmEL?!m% +NqWX (T΂OҲdyV7Y9[Wf%Qd*B\CqR^ )$ƶvv>CV72.i݅׬:Sl$L!Ɣa#iѣ3-}!$4Z<%HG`YcַJu+HRRTP^ g+ -KBQ$-q] )_=$yy Gq'qVء'si1!.<56ڊP #I93 ʆ8#C mXq]QEQEQU}7Q UjEV-n>EQEQEB|)+ Cϼ Z[%iY9>qUsL]K&-,LdJ.{9w%H:H#ƌ<(e)|d+۞:Kh"EAEiW3%0HCPw:pNY5ٛz mZ@K (,8Jȵ\[ bPRz iA9ҝD5 }mP"]\N[J'1YLmTZ.\t [*Y@gӢ᳗WZOpTDEQEQET(sNa-y u dVl0ffM(m!#Yky1糼uۋuORa$dĚʊ((*/J7a@jEG,>stream endstream endobj 2184 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\037)31(\025\001\026\002\025\007\220\002\215\016\024\013\205 \227\220\002\n\215\007\ \205\002\001\013\205 \201\220\007\013\026)11(\013\227\220\205 \220\022\f\025\n)10(\025\r\013\205 )]TJ 0 -1 TD [(\221\025\201\n)10(\025\217\001\013\205 \006\225\220\001\n)-10(\026)11(\016\002\025\026)11(\025\024\220\205 \221\002\220\022\007\016\017\016\001\220\220 \207\002\025\ \001\220\017\016\006\n\220\207 )]TJ T* [(\013\001\013\007\216\001\020\207 \026\002\016\224\220\001 \r\022\006\025\ \017\016\026)11(\013\001\220\220 \006\022\202)10(\016\024\025\002\002\025\016\024 3\2344\022\006)-10(\026)11(\013\201\220\220)]TJ 32.735 2 Td [(\021ontr)20(olled cir)31(cular dilatation and later)21.1(al subcutaneous sphincter)20(otom)21(y )]TJ 4.673 -1 Td [(for chr)20.1(onic anal f)-20.9(issur)31(es associated with h)11(emorrh)11(oids III-IV)]TJ ET 0 0 0 1 K 1 j 1 J [0 2.997]0 d /GS1 gs q 1 0 0 1 46.0167 560.8533 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 43.0197 560.8533 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q [0 2.997]0 d q 1 0 0 1 46.0167 523.6455 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 43.0197 523.6455 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q 0 j 0 J q 1 0 0 1 42.5197 469.5764 cm 0 0 m 453.543 0 l S Q BT 0 0 0 1 k /T1_1 1 Tf 0.085 Tw 9 0 0 9 90.7087 730.4919 Tm [(sphinctero)13.1(tom)11(y \(BPS\). In bo)13(th g)14(roups, patient under)-32(w)12(ent chronic anal f)-42.9(issure e)-15(xcision and surgical treatment of )]TJ 0 Tw 0 -1.111 TD [(hemor)-16(rhoids.)]TJ 0.029 Tw T* [(RESUL)30(T)-10(S: the postoperativ)13.1(e pain in g)14(roup CCD w)13(as signif)-43(icantly low)12(er than in the BPS g)14(roup dur)-37(ing all 7 d)26(ays af)-46(ter )]TJ 0.094 Tw T* [(surg)12(er)-43(y )0.5(\(p)]TJ /Span<>> BDC ( )Tj EMC 4.429 0 Td (=)Tj /Span<>> BDC ( )Tj EMC 0.827 0 Td [(0.0085; )0.5(p)]TJ /Span<>> BDC ( )Tj EMC 4.223 0 Td (=)Tj /Span<>> BDC ( )Tj EMC 0.827 0 Td (0.0001)Tj /Span<>> BDC ( )Tj EMC 3.123 0 Td [(\227 )0.5(on )0.5(the second )0.6(and )0.5(the )0.5(7th )0.5(d)26(ays, )0.5(respectiv)13(ely\). )0.5(On )0.5(the )0.5(7th )0.5(d)26(ay )0.5(af)-46(ter )0.5(surg)12(er)-43(y )]TJ 0.191 Tw -13.428 -1.111 Td [(according to the p)46(rof)-43(ilometr)-42.9(y the CCD method w)13(as more ef)-39.9(fectiv)13(e in liq)14(uid)26(ation inter)-14(nal sphincter h)12(yper)-40(tonia )]TJ 0.029 Tw 0 -1.111 TD (\(p)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0.01\), on the 45th)Tj /Span<>> BDC ( )Tj EMC [(\227 bo)13(th methods w)12(ere com)16(parable \(p)]TJ /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC [(0.27\). On the 45th d)26(ay af)-45.9(ter the surg)12(er)-43(y)42(, v)16(alues of )]TJ 0.052 Tw 0 -1.111 TD [(rest intraanal p)46(ressure descr)-37(ibing of the CCD and BPS methods had a com)16(parable ef)-40(fect on inter)-14(nal anal sphincter )]TJ 0.042 Tw T* [(function )0.5(\(p)]TJ /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC 5.508 0 Td [(0.45\), )0.5(as )0.5(w)12(ell )0.5(as )0.5(the )0.5(e)-15(xter)-13.9(nal )0.5(sphincter )0.5(\(p)]TJ /Span<>> BDC ( )Tj EMC 16.857 0 Td (>)Tj /Span<>> BDC ( )Tj EMC 0.775 0 Td [(0.05\). )0.5(On )0.5(the )0.5(45th )0.5(af)-46(ter )0.5(surg)12(er)-43(y)42(, the rate )0.5(of )0.5(postopera)]TJ 0 Tw (-)Tj 0.07 Tw -23.14 -1.111 Td [(tiv)13(e w)12(ounds healing in the BPS g)14(roup w)13(as 100%, in the CCD g)14(roup)]TJ /Span<>> BDC ( )Tj EMC (\227 85.4% \(p)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC [(0.02\). P)15(er)-37(ineal hematoma w)13(as )]TJ -0.02 Tw T* [(statistically more common in the BPS g)14(roup \(p)]TJ /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC [(0.014\). In the freq)14(uency of the incidence anal incontinence clinical )]TJ 0.023 Tw T* [(manifestations \(AI\) on the 45th d)26(ay)42.1(, CCD and BPS g)14(roups w)12(ere com)16(parable \(p)]TJ /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0.84\).)Tj -0.033 Tw T* [(C)21(ON)22(CLUSION: )0.6(CCD )0.5(and )0.6(BPS )0.5(methods )0.6(of )0.5(inter)-13.9(nal )0.5(anal )0.6(sphincter )0.5(h)12(yper)-39.9(tonia )0.5(liq)13.9(uid)26(ation )0.5(are )0.5(com)16(parable )0.5(in )0.5(the )0.6(ef)-40(fectiv)13(e)]TJ 0 Tw (-)Tj 0.061 Tw T* [(ness, the ov)13(erall incidence of postoperativ)13.1(e com)16(plications, including tem)16(porar)-43(y AI. The adv)16(antag)12(es of CCD method )]TJ 0.023 Tw T* [(are a lesser pain syndrome and a low incidence of per)-36.9(ineal hematoma in the near postoperativ)13(e per)-37(iod.)]TJ /T1_2 1 Tf 0.01 Tc -0.01 Tw 8 0 0 8 42.5596 585.2226 Tm [(KEYW)22(ORDS:)]TJ /T1_1 1 Tf 0 Tc 0.023 Tw 4.948 0 Td [( chronic anal f)-43(issure, C)-18(AF)105(, spas)33(m of inter)-14(nal anal sphincter)61(, inter)-14(nal anal sphincter h)12(yper)-39.9(tonia, controlled circular dilation, CCD)]TJ /T1_2 1 Tf 0.01 Tc 0.018 Tw -4.948 -1.909 Td [(C)19(ONFL)-33(ICT)5( OF)5( INTE)25(REST)62(:)]TJ /T1_1 1 Tf 0 Tc 0.023 Tw 9.871 0 Td [( the authors declare no conf)-22(lict of interest)]TJ /T1_2 1 Tf 0.037 Tc 0.157 Tw -9.871 -2.617 Td [(F)3.2(O)-4.6(R)8.7( C)-17.4(I)-15.6(T)45.4(A)37.5(T)-24.5(I)-1.2(ON:)]TJ /T1_3 1 Tf 0.023 Tc 0.166 Tw 6.601 0 Td [( K)-30.4(a)-9.6(m)-8.3(a)-15(e)-15.8(v)-28.4(a)]TJ /Span<>> BDC ( )Tj EMC [(Z)-22.9(.)-28.6(Z)-22.9(.)-23.4(, T)-17.3(i)-15.8(t)-21.9(o)-10.3(v A)-23(.)51.6(Y)12.6(u)-9(.)-23.5(, K)-20.5(h)-6.6(r)-60.6(y)-21.5(u)-9.6(k)-41.1(i)-3.2(n R)-21.4(.)51.6(Y)12.7(u)-9(.)-23.5(, A)-12.6(n)-11.9(o)-15.8(s)-19.1(o)-10.3(v)]TJ /Span<>> BDC ( )Tj EMC [(I)-10.3(.)-26.9(S)-9.6(.)-23.5(, S)-10.3(h)-15.1(e)-18(l)-8.3(y)-17.2(g)-28.9(i)-3.2(n)]TJ /Span<>> BDC ( )Tj EMC [(Y)51.3(.)-23.9(A)-22.9(. \221)-16.4(o)-9.3(n)-17.3(t)-30.8(r)-15.7(o)-15.6(l)-28.4(l)-23.7(e)-21(d c)-38.2(i)-6(r)-11.7(c)-12.1(u)-8.4(l)-37.8(a)-10.2(r d)-15.8(i)-7.1(l)-37.8(a)-18.2(t)-36.8(a)-18.2(t)-46.2(i)-6.8(o)-9.2(n a)-7.6(n)-14.5(d l)-37.8(a)-18.2(t)-24.7(e)-12.1(r)-30.8(a)-11.4(l)23.1( )]TJ 0.135 Tw -6.606 -1.2 Td [(s)-8.8(u)-13.5(b)-18.6(c)-12.1(u)-16.3(t)-36.8(a)-7.6(n)-16.1(e)-21(o)-13.3(u)-21.9(s s)-9.3(p)-15.9(h)-14(i)-3.2(n)-10(c)-41.5(t)-24.7(e)-12.1(r)-15.8(o)-15.8(t)-21.9(o)-9.2(m)-15.4(y f)-25.2(o)-11.8(r c)-10.2(h)-6.6(r)-15.8(o)-9.2(n)-14(i)-5(c a)-7.6(n)-7.8(a)-11.4(l f)-63(i)-7.4(s)-22.3(s)-8.8(u)-7.6(r)-19.1(e)-22.8(s a)-26.6(s)-22.3(s)-19.1(o)-16.8(c)-38.2(i)-5.1(a)-18.2(t)-24.7(e)-21(d w)-45.7(i)-15.8(t)-26.1(h h)-15.1(e)-11.5(m)-12.4(o)-11.8(r)-40.5(r)-28.4(h)-10.9(o)-12.5(i)-8.8(d)-24.7(s I)-26.6(I)-26.6(I)12.4(-)12.4(I)-36(V)39.7(. )]TJ /T1_1 1 Tf 0.033 Tc -0.033 Tw [(K)14(ol)3.6(op)2.4(r)3.1(o)3.5(k)-19.2(t)2.2(ol)3.6(o)-3.3(g)-13.2(i)6.8(a)5.8(.)]TJ /T1_3 1 Tf 0.013 Tc 0.145 Tw 48.377 0 Td [( 2)-18.9(0)-13.8(2)-1.2(4;2)-20.3(3)-4(\()27.7(1)34.3(\))4.5(:)-5.7(4)-24.2(2\226)-18.5(5)28.2(1)-5.7(.)13( )]TJ 0.023 Tc 0.024 Tw -48.377 -1.2 Td [(\()-0.9(i)-3.2(n)]TJ /Span<>> BDC ( )Tj EMC [(R)-6.5(u)-21.9(s)-22.3(s)-15.5(.)43.2(\))10.4(.)]TJ /Span<>> BDC ( )Tj EMC [(h)-17.1(t)-49.4(t)-29.4(p)-18.7(s)-8(:)1.9(/)84.7(/)36.4(d)-11.1(o)-12.5(i.)2.7(o)-11.8(r)-16.7(g)-22.8(/)11.2(1)14(0)6.5(.)-5.6(3)7.9(3)-15.9(8)1.3(7)4.6(8/)7.9(2)-8.9(0)9.3(7)-1.9(3)-13.3(-)41.2(7)10.7(55)-8.9(6)-26.7(-)9.7(2)-8.9(0)-3.8(2)8.7(4)-28.4(-)9.7(2)-10.3(3)-13.4(-)55.1(1)26.9(-)-30.2(4)-14.2(2)12.2(-)-7.9(5)38.2(1)]TJ /T1_2 1 Tf 0.01 Tc 0.108 Tw 0.005 -2.617 Td [(\026\020\021\033\030)5( \020\036\017)5( \013\033\021\033\013\023\030\037\023:)]TJ /T1_1 1 Tf 0 Tc 0.113 Tw 10.757 0 Td ( \222\026\003\026\031\027\026 \221.\221., \225\210\213\214 \253\217\240\215\ \037 \013\n\023\n\033\032\n\013\024\n\023\n\202\025\025 \025\003\031\021\ \025 \201.\217.)Tj /Span<>> BDC ( )Tj EMC (\212\020\204\025\004\273 \240\025\021\016\030\032\026\027\026 \212\n\t\t\ \025\025, \205\023.)Tj /Span<>> BDC ( )Tj EMC (\207\026\023\002\003\026 \201\030\025\023\002, \030.)Tj /Span<>> BDC ( )Tj EMC (2, )Tj 0.023 Tw -10.762 -1.2 Td (\240\n\t\013\027\026, 123423, \212\n\t\t\025\002; \003\n\005. \024\031\023\ .:)Tj /Span<>> BDC ( )Tj EMC (+7 \(915\) 005-34-85; e-mail: zkamaeva1990@gmail.com)Tj /T1_2 1 Tf 0.01 Tc 0.088 Tw 0.005 -1.2 Td [(ADDRESS)5( F)13(OR)5( C)19(ORRESPONDEN)23(CE:)]TJ /T1_1 1 Tf 0 Tc 0.093 Tw 14.191 0 Td [( K)17(amaev)16(a Z.Z., Ryzhikh N)18(ational Medical R)21(esearch Center of Colop)46.1(roctology)42(, Salyama Adilya st., 2, Moscow)52(, )]TJ 0.023 Tw -14.196 -1.2 Td [(123423, R)22(ussia; tel.:)]TJ /Span<>> BDC ( )Tj EMC [(+7 \(915\) 005-34-85; e-mail: zk)11(amaev)16(a1990@gmail.com)]TJ 0 Tw 0 -2.792 TD (\200\026\024\026 \033\n\t\024\205\033\023\031\021\025\002)Tj /Span<>> BDC ( )Tj EMC (\227 15.11.2023)Tj /Span<>> BDC ( )Tj EMC 19.488 0 Td (\n\t\023\031 \030\n\032\026\005\n\024\013\025)Tj /Span<>> BDC ( )Tj EMC (\227 19.12.2023)Tj /Span<>> BDC ( )Tj EMC 18.78 0 Td (\032\025\021\002\024\n \013)Tj /Span<>> BDC ( )Tj EMC (\033\205\005\023\025\013\026\203\025\025)Tj /Span<>> BDC ( )Tj EMC (\227 12.02.2024)Tj ( )Tj -38.268 -1.375 Td (Received)Tj /Span<>> BDC ( )Tj EMC (\227 15.11.2023)Tj /Span<>> BDC ( )Tj EMC 19.488 0 Td (Revised)Tj /Span<>> BDC ( )Tj EMC (\227 19.12.2023)Tj /Span<>> BDC ( )Tj EMC 18.78 0 Td (Accepted for publication)Tj /Span<>> BDC ( )Tj EMC (\227 12.02.2024)Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 42.5896 408.2019 Tm (\023\023\034\226\034\022\031\034)Tj 0 0 0 1 k /GS1 gs /T1_3 1 Tf 0 Tc 0.244 Tw 10 0 0 10 42.5197 383.8459 Tm (\203\026\017\002\024\035\036\036 \220\235\235\036\022\021\017\r\027\t\n \ \f\023\024\f\024\002\024\n \035\036\004\036\027\017\016 \f\023\026\f\021\ \017)Tj 0 Tw (-)Tj 0.173 Tw 0 -1.218 TD (\004\036\f\022\024\020\024 \f\024\f\021\024\016\027\017\016 \n\t\001\036\ \004\027\t\b \f\021\030\031\022\021\031\030 \r\027\031\021\030\036\027\027\ \036\020\024 )Tj 0.038 Tw T* (\026\027\026\035\034\027\024\020\024 \f\235\017\027\022\021\036\030\026 \ \(\200\202\221\), \023\024)Tj /Span<>> BDC ( )Tj EMC (\007\026\027\027\t\n \f\024\r\030\036\n\036\027\027\024\005 )Tj 0.367 Tw T* [(\035\017\021\036\030\026\021\031\030\t, \023\030\017\027\016\021\024 )0.5(\f\004\017\021\026\021\034 \002\024\022\024\r\031\033 \023\024\007\022\024\ \032\027\031\033 )]TJ -0.046 Tw T* (\f\235\017\027\022\021\036\030\024\021\024\n\017\033 \(\207\215\221\), \022\ \024\021\024\030\026\016 \001\017\030\024\022\024 \023\030\017\n\036\027\ \016\036\021\f\016 )Tj -0.013 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\n\017\030\024\r\024\005 \023\030\026\022\021\017\022\036 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\035\036\004\036\027\017\017 \b\030\024\027\017\004\036\f\022\024\005 \026\ \027\026\035\034)Tj 0 Tw (-)Tj 0.019 Tw T* (\027\024\005 \021\030\036\013\017\027\t \(\216\202\230\) [1\2264]. \212\026\ \027\027\026\016 \n\036\021\024\007\017\022\026 \023\024\r\024\035\016)Tj 0 Tw (-)Tj 0.048 Tw T* (\036\021 \027\026\007\036\032\027\024 \035\017\022\r\017\007\017\030\024\ \r\026\021\034 \f\023\026\n \200\202\221 \017)Tj /Span<>> BDC ( )Tj EMC (\007\024\002\017\021\034\f\016 \026)Tj 0 Tw (-)Tj -0.031 Tw T* (\032\017\r\035\036\027\017\016 \021\030\036\013\017\027\t \002\024\035\036\ \036, \004\036\n \031)Tj /Span<>> BDC ( )Tj EMC (90% \023\026\006\017\036\027\021\024\r [5\2267] )Tj 0.285 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC 0.954 0 Td [(\027\017\022\024\005 )0.6(\004\026\f\021\024\021\024\005 )0.5(\030\036\006\017\007\017\r\026 )0.5(\026\002\024\035\036\r\026\027\017\016. )0.6(\210\007\027\026\022\024 )]TJ 0.376 Tw -0.954 -1.218 Td (\030\017\f\022 \030\026\r\017\021\017\016 \024\f\035\024\032\027\036\027\ \017\005 \r)Tj /Span<>> BDC ( )Tj EMC (\023\024\f\035\036\024\023\036\030\026\006\017\024\027\027\024\n )Tj 0.137 Tw T* (\023\036\030\017\024\007\036 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\035\036\004\036\027\017\017 \216\202\230 \r)Tj /Span<>> BDC ( )Tj EMC (\f\024\004\036\021\026\027\017\017 \f)Tj /Span<>> BDC ( )Tj EMC (\020\036\n\024\030\030\024\036\n )Tj 0.193 Tw T* (\023\024\007\027\017\b \f\021\026\007\017\005 \023\031\021\036\n \030\026\ \f\f\036\004\036\027\017\016 \n\t\001\036\004\027\t\b \r\024\035\024)Tj 0 Tw (-)Tj 0.165 Tw T* (\022\024\027 \200\202\221 \027\036 \023\024\r\024\035\016\036\021 \f\004\ \017\021\026\021\034 \220\021\031 \n\036\021\024\007\017\022\031 \017\f\022\ \035\033)Tj 0 Tw (-)Tj 0.067 Tw T* [(\004\017\021\036\035\034\027\024\005 )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC 5.396 0 Td [(\023\024\002\031\032\007\026\036\021 )0.6(\022\024\035\024\023\030\024\022\021\024\035\024\020\024\r )0.5(\r\f\036\020\024 )0.5(\n\017\030\026 )]TJ 0.059 Tw -5.396 -1.218 Td (\023\030\024\007\024\035\032\026\021\034 \023\024\017\f\022 \027\036 \n\036\ \027\036\036 \220\235\235\036\022\021\017\r\027\024\020\024, \027\024 \002\ \024\035\036\036 )Tj 0.041 Tw T* (\013\026\007\016\013\036\020\024 \f\023\024\f\024\002\026 \035\036\004\036\ \027\017\016 \f\023\026\f\021\017\004\036\f\022\024\020\024 \f\024\f\021\ \024\016\027\017\016 )Tj 0 Tw T* (\003\202\215\025 [6,8].)Tj 0.053 Tw T* (\210\007\027\017\n \017)Tj /Span<>> BDC ( )Tj EMC (\n\036\021\024\007\024\r \035\017\022\r\017\007\026\006\017\017 \f\023\026\ \n\026 \200\202\221, \017\f\022\035\033\004\026)Tj 0 Tw (-)Tj 0.031 Tw T* [(\033\013\036\020\024 )0.5(\030\026\f\f\036\004\036\027\017\036 )0.6(\n\t\001\036\004\027\t\b )0.6(\f\021\030\031\022\021\031\030 )0.5(\003\202\215\025, )0.5(\016\r\035\016\036\021)]TJ 0 Tw (-)Tj 0.033 Tw T* (\f\016 \026\027\026\035\034\027\026\016 \007\017\035\026\021\026\006\017\ \016. \210\007\027\026\022\024 \024\021\f\031\021\f\021\r\017\036 \017\027\ \235\024\030\n\026)Tj 0 Tw (-)Tj 0.11 Tw T* (\006\017\017 \024)Tj /Span<>> BDC ( )Tj EMC (\f\023\024\f\024\002\026\b \022\024\027\021\030\024\035\016 \023\030\024\ \r\024\007\017\n\024\005 \n\026\027\017\023\031\035\016\006\017\017, )Tj 0.453 Tw T* (\027\036 \023\024\r\024\035\016\036\021 \001\017\030\024\022\024 \023\030\ \017\n\036\027\016\021\034 \007\026\027\027\t\005 \f\023\024\f\024\002 )Tj 0.184 Tw T* (\035\017\022\r\017\007\026\006\017\017 \f\235\017\027\022\021\036\030\024\ \f\023\026\n\026 [9]. \221\017\f\021\036\n\026\021\017\004\036\f\022\017\ \005 )Tj 0.14 Tw T* (\024\002\024\030 \035\017\021\036\030\026\021\031\030\t \017)Tj /Span<>> BDC ( )Tj EMC (\n\036\021\026\026\027\026\035\017 9 \030\026\027\007\024\n\017\017\030\ \024\r\026\027)Tj 0 Tw (-)Tj 0.455 Tw T* [(\027\t\b \017\f\f\035\036\007\024\r\026\027\017\005, \023\024\f\r\016\013\ \036\027\027\t\b )0.5(\f\030\026\r\027\036\027\017\033 )0.5(\207\215\221 )]TJ 0.451 Tw 23.244 34.098 Td (\017)Tj /Span<>> BDC ( )Tj EMC (\007\017\035\026\021\026\006\017\024\027\027\t\b \n\036\021\024\007\024\r\ \(\212\204\) \030\036\035\026\022\f\026\006\017\017 \200\202\221 )Tj 0.293 Tw T* (\023\030\017)Tj /Span<>> BDC ( )Tj EMC (\035\036\004\036\027\017\017 \216\202\230, \023\030\024\007\036\n\024\027\ \f\021\030\017\030\024\r\026\035\017 \f\024\023\024\f\021\026\r\017)Tj 0 Tw (-)Tj 0.247 Tw T* (\n\t\036 \030\036\031\035\034\021\026\021\t \r)Tj /Span<>> BDC ( )Tj EMC (\024\021\027\024\001\036\027\017\017 \004\026\f\021\024\021\t \026\032\017\ \r\035\036\027\017\016, )Tj 0.252 Tw T* (\004\026\f\021\024\021\t \030\026\r\017\021\017\016 \023\024\f\035\036\024\ \023\036\030\026\006\017\024\027\027\t\b \024\f\035\024\032\027\036\027\017\ \016, )Tj 0.056 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC 0.763 0 Td [(\021\024\n )0.5(\004\017\f\035\036 )0.5(\021\030\026\027\017\021\024\030\027\024\005 )0.6(\027\036\007\024\f\021\026\021\024\004\027\024\f\021\017 )0.6(\026\027\026\035\034\027\024)]TJ 0 Tw (-)Tj 0.113 Tw -0.763 -1.218 Td (\020\024 \f\235\017\027\022\021\036\030\026 \017)Tj /Span<>> BDC ( )Tj EMC (\030\036\006\017\007\017\r\026 \026\002\024\035\036\r\026\027\017\016 [\ 10]. \210\007\027\026\022\024 )Tj -0.027 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (5 \017)Tj /Span<>> BDC ( )Tj EMC (9 \017\f\f\035\036\007\024\r\026\027\017\005, \r\024\001\036\007\001\017\ \b \r)Tj /Span<>> BDC ( )Tj EMC (\026\027\026\035\017, \007\017\035\026\021\026\006\017\016 )Tj 0.028 Tw T* (\r\t\023\024\035\027\016\035\026\f\034 \030\031\004\027\t\n \f\023\024\f\ \024\002\024\n, \r)Tj /Span<>> BDC ( )Tj EMC (\024\f\021\026\035\034\027\t\b 4 \017\f\f\035\036)Tj 0 Tw (-)Tj 0.238 Tw T* (\007\024\r\026\027\017\016\b \023\030\017\n\036\027\016\035\017\f\034 \023\ \024\023\t\021\022\017 \r\t\023\024\035\027\036\027\017\016 \002\024\035\ \036\036 )Tj 0.001 Tw T* (\013\026\007\016\013\036\005 \007\017\035\026\021\026\006\017\017 \030\026\ \035\017\004\027\t\n\017 \023\030\017\f\023\024\f\024\002\035\036\027\017\ \016\n\017. )Tj 0.024 Tw T* (\224\021\024\021 \235\026\022\021 \023\024\r\024\035\016\036\021 \007\026\ \021\034 \001\026\027\f \022\024\027\021\030\024\035\017\030\031\036\n\t\ \n \f\023\024)Tj 0 Tw (-)Tj 0.026 Tw T* (\f\024\002\026\n \026\027\026\035\034\027\024\005 \007\017\035\026\021\026\ \006\017\017 \023\024\f\035\031\032\017\021\034 \r)Tj /Span<>> BDC ( )Tj EMC (\r\017\007\036 \026\035\034\021\036\030)Tj 0 Tw (-)Tj 0.288 Tw T* [(\027\026\021\017\r\027\024\020\024 )0.5(\r\026\030\017\026\027\021\026 )0.5(\035\017\022\r\017\007\026\006\017\017 )0.5(\f\235\017\027\022\021\036\030\024\f\023\026\n\026. )]TJ 0.054 Tw T* (\200)Tj /Span<>> BDC ( )Tj EMC (\205\206\207\211 \253\203\204\222\037 \022\024\035\024\023\030\024\022\021\ \024\035\024\020\017\017 \017\n\036\027\017 \202.\203. \217\t\032\017\b\273\ )Tj 0.057 Tw T* (\002\t\035 \023\030\036\007\035\024\032\036\027 \f\023\024\f\024\002 \r\t\ \023\024\035\027\036\027\017\016 \022\024\027\021\030\024\035\017\030\031\ \036\n\024\005 )Tj 0.504 Tw T* (\006\017\030\022\031\035\016\030\027\024\005 \007\017\035\026\021\026\006\ \017\017 \(\025\037\212\) \021\036\027\024\n\036\021\030\017\004\036\f\022\ \017\n )Tj 0.146 Tw T* [(\026\027\026\035\034\027\t\n )0.6(\007\017\035\026\021\026\021\024\030\024\n )0.5(\(\230\202\212\) )0.5(\007\035\016 )0.5(\035\017\022\r\017\007\026\006\017\017 )0.6(\f\023\026)]TJ 0 Tw (-)Tj 0.197 Tw T* (\n\026 \200\202\221 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\035\036\004\036\027\017\017 \216\202\230 \r)Tj /Span<>> BDC ( )Tj EMC (\f\024\004\036\021\026\027\017\017 \f)Tj /Span<>> BDC ( )Tj EMC (\020\036\n\024\030\030\024\036\n )Tj 0.076 Tw T* (3\2264)Tj /Span<>> BDC ( )Tj EMC (\f\021\026\007\017\017. \200)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\005 \f\r\016\017, \027\026\n\017 \002\t\035\024 \030\036\001\ \036\027\024 \023\030\024\r\036)Tj 0 Tw (-)Tj 0.06 Tw T* (\f\021\017 \030\026\027\007\024\n\017\017\030\024\r\026\027\027\024\036\ \017\f\f\035\036\007\024\r\026\027\017\036, \023\024\f\r\016\013\036\027\ \027\024\036 )Tj 0.078 Tw T* (\f\030\026\r\027\036\027\017\033 \030\036\031\035\034\021\026\021\024\r\ \035\036\004\036\027\017\016 \b\030\024\027\017\004\036\f\022\017\b \026\ \027\026\035\034)Tj 0 Tw (-)Tj 0.056 Tw T* [(\027\t\b )0.5(\021\030\036\013\017\027 \f\024 )0.5(\f\023\026\n\024\n )0.5(\f\235\017\027\022\021\036\030\026 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC [(\f\024\004\036\021\026\027\017\017 )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC (\020\036)Tj 0 Tw (-)Tj T* (\n\024\030\030\024\036\n 3\2264)Tj /Span<>> BDC ( )Tj EMC (\f\021\026\007\017\017 \n\036\021\024\007\026\n\017 \025\037\212 \017)Tj /Span<>> BDC ( )Tj EMC (\207\215\221.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 0.01 Tc 0.018 Tw 14 0 0 14 275.0305 115.9299 Tm [(\017\034\r\241)5( \031\032\032\r\034\226\037\023\026\022\031\025)]TJ 0 0 0 1 k /GS1 gs /T1_3 1 Tf 0 Tc 0.154 Tw 10 0 0 10 274.9606 91.5739 Tm [(\210\006\036\027\017\021\034 \030\036\031\035\034\021\026\021\t \035\036\ \004\036\027\017\016 )0.5(\b\030\024\027\017\004\036\f\022\024\005 \026\027\026\035\034\027\024\005\ )]TJ 0 Tw T* (\021\030\036\013\017\027\t \r)Tj /Span<>> BDC ( )Tj EMC (\f\024\004\036\021\026\027\017\017 \f)Tj /Span<>> BDC ( )Tj EMC (\020\036\n\024\030\030\024\036\n 3\2264)Tj /Span<>> BDC ( )Tj EMC (\f\021\026\007\017\017.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\033\030\031\030\213\b)-20.9(\035\231\213\233\t \021\032)50(\b)42(\032\231\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj /T1_5 1 Tf 25 0 0 25 512.902 56.0378 Tm (43)Tj ET endstream endobj 2181 0 obj [2189 0 R] endobj 2182 0 obj <>stream q /GS0 gs /Fm0 Do Q 0 0 0 1 K 1 j 1 J [0 2.997]0 d /GS1 gs q 1 0 0 1 74.3631 319.4103 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 71.3661 319.4103 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q [0 2.997]0 d q 1 0 0 1 74.3631 282.2025 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 71.3661 282.2025 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q BT 0 0 0 1 k /T1_0 1 Tf 10 0 0 10 70.8661 724.8299 Tm (https://doi.org/10.33878/2073-7556-2024-23-1-42-51)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0.023 Tw 19 0 0 19 92.6378 695.3259 Tm [(\037)31(\025\001\026\002\025\007\220\002\215\016\024\013\205 \227\220\002\n\215\007\ \205\002\001\013\205 \201\220\007\013\026)11(\013\227\220\205 \220\022)-23.3(\f\025\n)10(\025\r\013\205 )]TJ -0.546 -1.105 Td [(\221\025\201\n)10(\025\217\001\013\205 \006\225\220\001\n)-10(\026)11(\016\002\025\026)11(\025\024\220\205 \221\002\220\022)-23.2(\007\016\017\016\001\220\220 \207\002\025\001\220\017\016\006\n\220\207 \ )]TJ -0.238 -1.105 Td [(\013\001\013\007\216\001\020\207 \026\002\016\224\220\001 \r\022)-23.2(\006\025\017\016\026)11(\013\001\220\220 \006\022)-23.3(\202)10(\016\024\025\002\002\025\016\024 3\2344\022)-23.3(\006)-10(\026)11(\013\201\220\220)]TJ 0 0 0 1 k /GS1 gs 0 Tw 14 0 0 14 70.8661 628.822 Tm [(\037)41(\013\024\013\016\r\013\022)-23.3(\211.\211.)]TJ 8.162 0 0 8.162 148.4156 633.484 Tm (2)Tj 0.023 Tw 14 0 0 14 153.0515 628.822 Tm [(, \032)30(\220\026)11(\025\r\022)-23.2(\b)-31(.\200.)]TJ 0 Tw 8.162 0 0 8.162 226.5868 633.484 Tm (1)Tj 0.023 Tw 14 0 0 14 231.2227 628.822 Tm [(, \204\002\212\n\220\001\022)-23.2(\033)124(.\200.)]TJ 0 Tw 8.162 0 0 8.162 314.026 633.484 Tm (1)Tj 0.023 Tw 14 0 0 14 318.662 628.822 Tm [(, \b\001\025\006\025\r\022)-23.2(\030.\021.)]TJ 0 Tw 8.162 0 0 8.162 399.0291 633.484 Tm (1)Tj 0.023 Tw 14 0 0 14 403.665 628.822 Tm [(, \206\016\007\020\202\220\001\022)-23.2(\200.\b)-31(.)]TJ -0.069 Tc 0.069 Tw 8.162 0 0 8.162 499.2216 633.484 Tm [(1,)-69(2)]TJ 0 Tc 0 Tw 5.83 0 0 5.83 70.8661 614.4827 Tm (1)Tj 0.023 Tw 10 0 0 10 74.1775 611.1527 Tm [(\210\031\214)42(\240 \253\213\005\030\226 \n)10(\025\007\025\221\002\025\n)-9.9(\026)11(\025\007\025\202\220\220 \220\024\016\001\220 \b)-30.9(.\213.\022)-23.3(\033\020\217\220\207\273 \005\220\001\222\201\002\013\r\013 \033\025\006\ \006\220\220 \(\215\007.\022)-23.3(\021\013\007\205\024\013 \b)-20.9(\201\220\007\205, \201.\022)-23.3(2, \202)62.1(.\022)-23.3(\005\025\006\n\r\013, )]TJ -0.331 -1.2 Td [(1)125(23)58(423, \033\025\006\006\220\205\))]TJ 0 Tw ( )Tj 5.83 0 0 5.83 70.8661 590.4827 Tm (2)Tj 0.023 Tw 10 0 0 10 74.1775 587.1527 Tm [(\210\031\214)21(\036)20(\240 \255\034\036 \033)21(\005\b\213\034\036 \005\220\001\222\201\002\013\r\013 \033\025\006\006\220\ \220 \(\215\007.\022)-23.2(\214\013\002\002\220\n\013\201\001\013\205, \201.\022)-23.3(2/1)69(, \006)-10(\026\002)-31(.\022)-23.3(1)69(, \202)62(.\022)-23.2(\005\025\006\n\r\013, 1)125(2)23(5)23(99)35(3, \033\025\006\006\220\205\))]TJ /T1_0 1 Tf 0.17 Tw 9 0 0 9 119.0551 568.6488 Tm [(\037\036\035\034 )0.5(\215\207\207\035\036\200\255\216\201\217\215\243: )0.5(\n\203\031\021\025\024\022 )0.5(\032\031\016\205\023\022\024\026\024\020 )0.5(\023\031\006\031\021\025\002 )0.5(\004\032\n\021\025\006\031\t\013\n\017 )0.5(\026\021\026\023\022\021\n\017 \024\032\031\211\025\021\020 )0.5(\t)]TJ /Span<>> BDC ( )Tj EMC (\t\n\033\205\024\t\024\027\205\007\211\025\003 )Tj 0.023 Tw 0 -1.111 TD (\202\031\003\n\032\032\n\031\003 3\2264)Tj /Span<>> BDC ( )Tj EMC (\t\024\026\030\025\025.)Tj 0.046 Tw T* (\201\037\215\036\217\220\235 \215)Tj /Span<>> BDC ( )Tj EMC (\240\036\220\255\200\235: \027)Tj /Span<>> BDC ( )Tj EMC (\025\t\t\023\031\030\n\027\026\021\025\031 \027\013\023\007\006\031\021\n\ 94 \033\026\203\025\031\021\024\026 \t)Tj /Span<>> BDC ( )Tj EMC (\004\032\n\021\025\006\031\t\013\n\017 \026\021\026\023\022\021\n\017 \024\ \032\031\211\025\021\n\017 \027)Tj /Span<>> BDC ( )Tj EMC (\t\n\006\031\024\026)Tj 0 Tw (-)Tj -0.012 Tw T* [(\021\025\025 )0.5(\t)]TJ /Span<>> BDC ( )Tj EMC 2.333 0 Td [(\202\031\003\n\032\032\n\031\003 )0.6(3\2264)]TJ /Span<>> BDC ( )Tj EMC 6.277 0 Td [(\t\024\026\030\025\025, )0.6(\032\026\021\030\n\003\025\016\025\032\n\027\026\021\021\020\004 )0.6(\003\031\024\n\030\n\003 )0.6(\202\031\021\031\032\026\203\025\025 )0.5(\t\023\205\006\026\017\021\020\004 )0.5(\006\025\t\031\023 )0.5(\027)]TJ /Span<>> BDC ( )Tj EMC 28.236 0 Td [(\013\n\003\033\022\007\024\031\032\021\n\017 )0.5(\033\032\n)]TJ 0 Tw (-)Tj 0.057 Tw -36.846 -1.111 Td (\202\032\026\003\003\031 \027)Tj /Span<>> BDC ( )Tj EMC (\030\027\031 \202\032\205\033\033\020. \207\n\032\n\013\026 \027\n\t\022\ \003\025 \033\026\203\025\031\021\024\026\003 \n\t\021\n\027\021\n\017 \202\ \032\205\033\033\020 \027\020\033\n\023\021\031\021\026 \013\n\021\024\032\ \n\023\025\032\205\031\003\026\002 \203\025\032\013\205\023\002\032\021\026\ \002 )Tj 0.113 Tw 0 -1.111 TD (\030\025\023\026\024\026\203\025\002 \(\222\037\200\), \025)Tj /Span<>> BDC ( )Tj EMC (46 \033\026\203\025\031\021\024\026\003 \013\n\021\024\032\n\023\022\021\ \n\017)Tj /Span<>> BDC ( )Tj EMC (\227 \005\n\013\n\027\026\002 \033\n\030\013\n\204\021\026\002 \t\f\025\021\ \013\024\031\032\n\024\n\003\025\002 \(\213\207\). \216)Tj /Span<>> BDC ( )Tj EMC (\n\005\031\025\004 )Tj 0.023 Tw 0 -1.111 TD (\202\032\205\033\033\026\004 \033\032\n\027\n\030\025\023\n\t\022 \025\t\ \t\031\006\031\021\025\031 \024\032\031\211\025\021\020 \025)Tj /Span<>> BDC ( )Tj EMC (\004\025\032\205\032\202\025\006\031\t\013\n\031 \023\031\006\031\021\025\ \031 \202\031\003\n\032\032\n\002.)Tj 0.164 Tw T* (\212\036\221\214\035\034\220\201\220\235: \027\020\032\026\204\031\021\021\ \n\t\024\022 \005\n\023\031\027\n\202\n \t\025\021\030\032\n\003\026 \027\ )Tj /Span<>> BDC ( )Tj EMC (\005\023\025\204\026\017\001\031\003 \033\n\t\023\031\n\033\031\032\026\203\ \025\n\021\021\n\003 \033\031\032\025\n\030\031 \027)Tj /Span<>> BDC ( )Tj EMC (\202\032\205\033\033\031 \222\037\200 )Tj -0.009 Tw T* [(\t\024\026\024\025\t\024\025\006\031\t\013\025 )0.6(\016\021\026\006\025\003\n )0.5(\021\025\204\031, )0.6(\006\031\003 )0.5(\027)]TJ /Span<>> BDC ( )Tj EMC [(\202\032\205\033\033\031 )0.5(\213\207 )0.5(\(\032)]TJ /Span<>> BDC ( )Tj EMC 21.274 0 Td (=)Tj /Span<>> BDC ( )Tj EMC 0.724 0 Td [(0,0085; )0.5(\032)]TJ /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC 4.649 0 Td (0,0001)Tj /Span<>> BDC ( )Tj EMC 2.928 0 Td [(\227 )0.5(\021\026)]TJ /Span<>> BDC ( )Tj EMC 2.429 0 Td [(2 )0.5(\025)]TJ /Span<>> BDC ( )Tj EMC [(7 )0.5(\t\205\024\013\025, \t\n\n\024\027\031\024\t\024\027\031\021\021\n\). )]TJ 0.034 Tw -32.003 -1.111 Td (\n)Tj /Span<>> BDC ( )Tj EMC (\030\026\021\021\020\003 \033\032\n\f\025\023\n\003\031\024\032\025\025,\ \021\026)Tj /Span<>> BDC ( )Tj EMC (7 \t\205\024\013\025 \033\n\t\023\031 \n\033\031\032\026\203\025\025 \003\ \031\024\n\030 \222\037\200 \005\020\023 \r\f\f\031\013\024\025\027\021\031\ \031 \027)Tj /Span<>> BDC ( )Tj EMC (\023\025\013\027\025\030\026\203\025\025 \t\f\025\021\013)Tj 0 Tw (-)Tj 0.011 Tw T* (\024\031\032\n\t\033\026\016\003\026 \(\032)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,01\), \021\026)Tj /Span<>> BDC ( )Tj EMC (45 \t\205\024\013\025)Tj /Span<>> BDC ( )Tj EMC (\227 \003\031\024\n\030\025\013\025 \005\020\023\025 \t\n\033\n\t\024\026\ \027\025\003\020 \(\032)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,27\). \217\026)Tj /Span<>> BDC ( )Tj EMC (45 \t\205\024\013\025 \033\n\t\023\031 \n\033\031\032\026\203\025\025 )Tj 0.034 Tw T* (\033\n)Tj /Span<>> BDC ( )Tj EMC (\205\032\n\027\021\007 \t\032\031\030\021\031\202\n \027\021\205\024\032\ \025\026\021\026\023\022\021\n\202\n \030\026\027\023\031\021\025\002 \027\ )Tj /Span<>> BDC ( )Tj EMC (\033\n\013\n\031 \003\031\024\n\030\025\013\025 \222\037\200 \025)Tj /Span<>> BDC ( )Tj EMC (\213\207 \n\013\026\016\020\027\026\023\025 \t\n\033\n\t\024\026\027\025\ \003\n\031 \027\023\025)Tj 0 Tw (-)Tj 0.108 Tw T* (\002\021\025\031 \021\026)Tj /Span<>> BDC ( )Tj EMC (\t\n\013\032\026\024\025\024\031\023\022\021\205\007 \t\033\n\t\n\005\021\ \n\t\024\022 \027\021\205\024\032\031\021\021\031\202\n \026\021\026\023\ \022\021\n\202\n \t\f\025\021\013\024\031\032\026 \(\032)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,45\), \026)Tj /Span<>> BDC ( )Tj EMC (\024\026\013\204\031 \021\026\032\205\204\021\n\202\n )Tj 0.075 Tw T* [(\t\f\025\021\013\024\031\032\026 )0.5(\(\032)]TJ /Span<>> BDC ( )Tj EMC (>)Tj /Span<>> BDC ( )Tj EMC 6.956 0 Td [(0,05\). )0.5(\217\026)]TJ /Span<>> BDC ( )Tj EMC [(45 \t\205\024\013\025 )0.5(\033\n\t\023\031 )0.5(\n\033\031\032\026\203\025\025 \006\026\t\024\n\024\026 )0.5(\016\026\204\025\027\023\031\021\025\002 )0.5(\033\n\t\023\031\n\033\031\032\026\203\025\n\021\021\020\004 \032\026\021\ )0.5(\027)]TJ /Span<>> BDC ( )Tj EMC (\202\032\205\033\033\031 )Tj 0.092 Tw -6.956 -1.111 Td [(\213\207 )0.5(\t\n\t\024\026\027\025\023\026 )0.5(100%, )0.5(\027)]TJ /Span<>> BDC ( )Tj EMC 10.146 0 Td [(\202\032\205\033\033\031 )0.5(\222\037\200)]TJ /Span<>> BDC ( )Tj EMC [(\227 )0.5(85,4%\(\032)]TJ /Span<>> BDC ( )Tj EMC 10.135 0 Td (=)Tj /Span<>> BDC ( )Tj EMC 0.825 0 Td [(0,02\). )0.5(\210\031\003\026\024\n\003\026 )0.5(\033\031\032\025\026\021\026\023\022\021\n\017 )0.5(\n\005\023\026\t\024\025 \t\024\026\024\025\t\024\025\006\031\t\013\025 \ )]TJ 0.037 Tw -21.106 -1.111 Td (\006\026\211\031 \027\t\024\032\031\006\026\023\026\t\022 \027)Tj /Span<>> BDC ( )Tj EMC (\202\032\205\033\033\031 \213\207 \(\032)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,014\). \n)Tj /Span<>> BDC ( )Tj EMC (\006\026\t\024\n\024\031 \013\023\025\021\025\006\031\t\013\025\004 \033\ \032\n\002\027\023\031\021\025\017 \021\031\030\n\t\024\026\024\n\006\021\ \n\t\024\025 \026\021\026\023\022)Tj 0 Tw (-)Tj 0.023 Tw T* (\021\n\202\n \t\f\025\021\013\024\031\032\026 \(\217\201\207\) \006\031\032\ \031\016 45 \030\021\031\017 \032\031\016\205\023\022\024\026\024\020 \202\ \032\205\033\033\020 \005\020\023\025 \t\n\033\n\t\024\026\027\025\003\020\ \(\032)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,84\).)Tj -0.008 Tw T* (\221\201\222\035\223\224\036\217\215\036: \003\031\024\n\030\025\013\025\ \222\037\200 \025)Tj /Span<>> BDC ( )Tj EMC (\213\207 \t\n\033\n\t\024\026\027\025\003\020 \027)Tj /Span<>> BDC ( )Tj EMC (\r\f\f\031\013\024\025\027\021\n\t\024\025 \023\025\013\027\025\030\026\203\ \025\025 \t\033\026\016\003\026 \027\021\205\024\032\031\021\021\031\202\ \n \026\021\026\023\022)Tj 0 Tw (-)Tj 0.153 Tw T* (\021\n\202\n \t\f\025\021\013\024\031\032\026, \n\005\211\031\017 \006\026\ \t\024\n\024\031 \032\026\016\027\025\024\025\002 \033\n\t\023\031\n\033\ \031\032\026\203\025\n\021\021\020\004 \n\t\023\n\204\021\031\021\025\017\ , \027)Tj /Span<>> BDC ( )Tj EMC (\024\n\003 \006\025\t\023\031 \024\032\026\021\016\025\024\n\032\021\n\017\ )Tj -0.006 Tw T* (\217\201\207. \032\031\025\003\205\211\031\t\024\027\026\003\025 \222\037\ \200 \002\027\023\002\031\024\t\002 \003\031\021\031\031 \027\020\032\026\ \204\031\021\021\020\017 \005\n\023\031\027\n\017 \t\025\021\030\032\n\003\ \027)Tj /Span<>> BDC ( )Tj EMC (\005\023\025\204\026\017\001\031\003 \033\n\t\023\031\n\033\031\032\026\203\ \025\n\021\021\n\003 )Tj 0.023 Tw T* (\033\031\032\025\n\030\031, \021\025\016\013\026\002 \006\026\t\024\n\024\ \026 \032\026\016\027\025\024\025\002 \202\031\003\026\024\n\003\020 \033\ \031\032\025\026\021\026\023\022\021\n\017 \n\005\023\026\t\024\025.)Tj /T1_2 1 Tf 0.01 Tc 0.204 Tw 8 0 0 8 70.906 353.3795 Tm [(\037\036\035\034\033\032\031\033)5( \030\036\027\032\026:)]TJ /T1_0 1 Tf 0 Tc 0.209 Tw 8.679 0 Td ( \004\032\n\021\025\006\031\t\013\026\002 \026\021\026\023\022\021\026\002\ \024\032\031\211\025\021\026, \206\201\220, \t\033\026\016\003 \027\021\ \205\024\032\031\021\021\031\202\n \026\021\026\023\022\021\n\202\n \t\f\ \025\021\013\024\031\032\026, \013\n\021\024\032\n\023\025\032\205\031\003\ \026\002 \203\025\032\013\205\023\002\032\021\026\002 )Tj 0.023 Tw -8.684 -1.2 Td (\030\025\023\026\024\026\203\025\002, \222\037\200)Tj /T1_2 1 Tf 0.01 Tc 0.018 Tw 0.005 -1.909 Td [(\037\027\025\024\036\023\037\022)5( \023\025\022\033\021\033\030\027\032:)]TJ /T1_0 1 Tf 0 Tc 0.023 Tw 10.401 0 Td ( \201\027\024\n\032\020 \016\026\002\027\023\002\007\024 \n\005 \n\024\t\ \205\024\t\024\027\025\025 \013\n\021\f\023\025\013\024\026 \025\021\024\ \031\032\031\t\n\027)Tj /T1_2 1 Tf 0.033 Tc 0.097 Tw -10.401 -2.617 Td [(\020\036\017)4.7( \016\023\022\023\021\027\032\026\025\023\017:)]TJ /T1_3 1 Tf 0.023 Tc 0.102 Tw 9.27 0 Td ( \025\026\n\026\036\r\026)Tj /Span<>> BDC ( )Tj EMC (\003.\003., \230\017\021\024\r)Tj /Span<>> BDC ( )Tj EMC (\202.\236., \216\030\033\022\017\027)Tj /Span<>> BDC ( )Tj EMC (\217.\236., \202\027\024\f\024\r)Tj /Span<>> BDC ( )Tj EMC (\222.\221., \234\036\035\t\020\017\027)Tj /Span<>> BDC ( )Tj EMC (\236.\202. \025\024\027\021\030\024\035\017\030\031\036\n\026\016 \006\017\ \030\022\031\035\016\030\027\026\016 \007\017\035\026\021\026)Tj 0 Tc 0 Tw (-)Tj 0.023 Tc 0.15 Tw -9.275 -1.2 Td (\006\017\016 \017)Tj /Span<>> BDC ( )Tj EMC (\002\024\022\024\r\026\016 \023\024\007\022\024\032\027\026\016 \f\235\017\ \027\022\021\036\030\024\021\024\n\017\016 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\035\036\004\036\027\017\017 \b\030\024\027\017\004\036\f\022\017\b \026\ \027\026\035\034\027\t\b \021\030\036\013\017\027 \r)Tj /Span<>> BDC ( )Tj EMC (\f\024\004\036\021\026\027\017\017 \f)Tj /Span<>> BDC ( )Tj EMC (\020\036\n\024\030\030\024\036\n 3\2264)Tj /Span<>> BDC ( )Tj EMC [(\f\021\026\007\017\017.)23( )]TJ /T1_0 1 Tf -0.023 Tw 0 -1.2 TD (\222\n\023\n\033\032\n\013\024\n\023\n\202\025\002.)Tj /T1_3 1 Tf 0.024 Tw ( 2024; \021.)Tj /Span<>> BDC ( )Tj EMC (23, \225)Tj /Span<>> BDC ( )Tj EMC 14.78 0 Td (1, \f.)Tj /Span<>> BDC ( )Tj EMC (42\22651. https://doi.org/10.33878/2073-7556-2024-23-1-42-51)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0 Tc 0.023 Tw 18 0 0 18 153.9091 256.0332 Tm [(\021ontr)20(olled cir)31(cular dilatation and later)21(al )]TJ -1.112 -1.167 Td [(subcutaneous sphincter)20.1(otom)21(y for chr)20(onic anal )]TJ 0.755 -1.167 Td [(f)-21(issur)31.1(es associated with h)11(emorrh)11.1(oids III-IV)]TJ 0 0 0 1 k /GS1 gs 0 Tw 14 0 0 14 70.8661 189.5292 Tm [(Z)21(arina\022)-23.2(Z.\022)-23.3(K)41(amae)11(v)10(a)]TJ 8.162 0 0 8.162 178.6174 194.1912 Tm (2)Tj 0.023 Tw 14 0 0 14 183.2533 189.5292 Tm [(, Alek)11(sandr\022)-23.2(Y)40(u.\022)-23.3(Titov)]TJ 0 Tw 8.162 0 0 8.162 298.3716 194.1912 Tm (1)Tj 0.023 Tw 14 0 0 14 303.0075 189.5292 Tm [(, Roman\022)-23.2(Y)39.9(u.\022)-23.2(Khr)-31(y)10(ukin)]TJ 0 Tw 8.162 0 0 8.162 424.0479 194.1912 Tm (1)Tj 14 0 0 14 428.6838 189.5292 Tm (, )Tj -25.558 -1.143 Td [(Iv)10(an\022)-23.3(S.\022)-23.2(Anosov)]TJ 8.162 0 0 8.162 154.9291 178.1912 Tm (1)Tj 0.023 Tw 14 0 0 14 159.5651 173.5292 Tm [(, Y)40(uri\022)-23.2(A)-31(.\022)-23.3(Sh)11(ely)10(gin)]TJ -0.069 Tc 0.069 Tw 8.162 0 0 8.162 257.1415 178.1912 Tm [(1,)-69(2)]TJ 0 Tc 0 Tw 5.83 0 0 5.83 70.8661 159.19 Tm (1)Tj 0.023 Tw 10 0 0 10 74.1775 155.86 Tm [(R)20(y)21(zhikh National Medical Resear)31(ch Center of Colopr)20.1(octology \(Saly)21(ama Adily)21(a\022)-23.3(st., 2, Moscow)22(, 1)125(23)58(423, Russia\))]TJ 0 Tw ( )Tj 5.83 0 0 5.83 70.8661 147.19 Tm (2)Tj 0.023 Tw 10 0 0 10 74.1775 143.86 Tm [(Russian Medical Academ)21.1(y of Continuous Pr)20(ofessional Education \(Barrikadnay)21.1(a\022)-23.3(st., 2/1)69(, Moscow)22(, 1)125(2)23(5)23(99)35(3, )]TJ 0 Tw -0.331 -1.2 Td (Russia\))Tj /T1_0 1 Tf 0.023 Tw 9 0 0 9 119.0551 113.3561 Tm [(AIM: to ev)16(aluate the results of treatment of chronic anal f)-43(issure in combination with g)14(rade 3\2264)]TJ /Span<>> BDC ( )Tj EMC [(hemor)-16(rhoids.)]TJ 0.065 Tw 0 -1.111 TD [(P)45(A)45(TIENT)-9.9(S A)53(ND METHODS: the p)46(rospectiv)13.1(e randomized )0.5(study included )0.5(94 patients with chronic anal f)-42.9(issure in com)]TJ 0 Tw (-)Tj 0.024 Tw T* [(bination with g)14(rade 3\2264)]TJ /Span<>> BDC ( )Tj EMC [(hemor)-15.9(rhoids, which had randomized in tw)12(o g)14(roups. F)12(or)-40(ty)-14(-eight patients in the main g)14(roup )]TJ 0.052 Tw T* [(under)-32(w)12(ent controlled circular dilation \(CCD\) and 46 patients in the control \ g)14(roup under)-32(w)12(ent lateral subcutaneous )]TJ ET 1 0.68 0 0.12 k /GS0 gs q 1 0 0 1 70.8661 577.1533 cm 0 0 m 0 0 l 0 -11.339 l 42.52 -11.339 l 42.52 0 l h f Q BT 0 0 0 0 k /T1_2 1 Tf 0 Tw 9 0 0 9 76.0071 568.226 Tm (\021\033\r\035\f\033)Tj ET 1 0.68 0 0.12 k q 1 0 0 1 70.8661 121.8604 cm 0 0 m 0 0 l 0 -11.339 l 42.52 -11.339 l 42.52 0 l h f Q BT 0 0 0 0 k /T1_2 1 Tf 9 0 0 9 73.5728 112.9331 Tm (ABSTRACT)Tj 1 0.68 0 0.12 k /T1_1 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\033\030\031\030\213\b)-20.9(\035\231\213\233\t \021\032)50(\b)42(\032\231\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj -51.938 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 23, \023\0221)69(, 202)69(4)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 23, \023\0221)69(, 202)69(4)]TJ /T1_4 1 Tf 25 0 0 25 28.1902 56.0378 Tm (42)Tj ET q 0 g 0 G 0 j 0 J /Fm1 Do Q 0 0 0 0 k 396.85 725.67 59.155 11.338 re f /PlacedPDF /MC0 BDC q 397.481 736.808 m 397.242 736.808 397.049 736.616 397.049 736.376 c 397.049 736.376 l 397.049 726.285 l 397.049 726.045 397.242 725.853 397.481 725.853 c 397.481 725.853 l 455.382 725.853 l 455.62 725.853 455.815 726.045 455.815 726.285 c 455.815 726.285 l 455.815 736.376 l 455.815 736.616 455.62 736.808 455.382 736.808 c 455.382 736.808 l h W n q 0 g -0.0000005 -10.9560913 -10.9560913 0.0000005 426.4320445 736.8086309 cm BX /Sh0 sh EX Q Q q 396.85 725.67 59.155 11.337 re W n 0 0 0 0.84 k q 1 0 0 1 413.5634 732.4249 cm 0 0 m -0.025 0.1 -0.063 0.196 -0.112 0.287 c -0.157 0.374 -0.218 0.451 -0.292 0.515 c -0.37 0.582 -0.46 0.632 -0.558 0.664 c -0.669 0.701 -0.786 0.719 -0.903 0.717 c -1.076 0.722 -1.247 0.681 -1.4 0.6 c -1.536 0.526 -1.652 0.42 -1.74 0.292 c -1.83 0.158 -1.895 0.008 -1.934 -0.149 c -2.018 -0.48 -2.018 -0.827 -1.934 -1.158 c -1.896 -1.316 -1.83 -1.466 -1.74 -1.602 c -1.653 -1.731 -1.536 -1.837 -1.4 -1.912 c -1.247 -1.993 -1.076 -2.033 -0.903 -2.029 c -0.774 -2.032 -0.647 -2.006 -0.528 -1.955 c -0.427 -1.906 -0.337 -1.837 -0.263 -1.753 c -0.185 -1.665 -0.124 -1.563 -0.082 -1.453 c -0.034 -1.338 0 -1.218 0.019 -1.094 c 0.635 -1.094 l 0.624 -1.297 0.578 -1.497 0.497 -1.684 c 0.421 -1.857 0.312 -2.015 0.175 -2.146 c 0.039 -2.277 -0.123 -2.379 -0.3 -2.446 c -0.492 -2.519 -0.695 -2.555 -0.9 -2.552 c -1.15 -2.557 -1.397 -2.506 -1.625 -2.404 c -1.829 -2.307 -2.01 -2.169 -2.157 -1.997 c -2.308 -1.821 -2.423 -1.617 -2.497 -1.397 c -2.655 -0.924 -2.655 -0.412 -2.497 0.061 c -2.423 0.281 -2.307 0.485 -2.157 0.661 c -2.01 0.833 -1.829 0.973 -1.625 1.07 c -1.398 1.174 -1.15 1.226 -0.9 1.222 c -0.707 1.223 -0.515 1.196 -0.329 1.14 c -0.159 1.088 0.001 1.006 0.144 0.898 c 0.278 0.793 0.39 0.662 0.473 0.513 c 0.562 0.349 0.615 0.167 0.629 -0.019 c 0 -0.019 l 0 0 l f Q q 1 0 0 1 414.6923 733.5723 cm 0 0 m 0.584 0 l 0.584 -1.328 l 0.662 -1.204 0.771 -1.103 0.9 -1.033 c 1.046 -0.951 1.213 -0.91 1.381 -0.914 c 1.627 -0.9 1.869 -0.979 2.058 -1.137 c 2.234 -1.312 2.325 -1.556 2.305 -1.803 c 2.305 -3.596 l 1.716 -3.596 l 1.716 -1.976 l 1.724 -1.817 1.678 -1.66 1.585 -1.53 c 1.486 -1.43 1.347 -1.379 1.206 -1.392 c 1.114 -1.39 1.024 -1.408 0.94 -1.445 c 0.865 -1.479 0.798 -1.529 0.744 -1.591 c 0.687 -1.656 0.645 -1.73 0.616 -1.812 c 0.586 -1.896 0.571 -1.986 0.571 -2.077 c 0.571 -3.615 l 0 -3.615 l 0 0 l f Q q 1 0 0 1 418.0385 731.1235 cm 0 0 m 0 -0.099 0.014 -0.198 0.043 -0.292 c 0.069 -0.382 0.112 -0.466 0.17 -0.54 c 0.229 -0.611 0.304 -0.669 0.388 -0.709 c 0.486 -0.754 0.594 -0.776 0.702 -0.773 c 0.845 -0.78 0.987 -0.742 1.108 -0.664 c 1.217 -0.582 1.296 -0.468 1.336 -0.337 c 1.881 -0.337 l 1.827 -0.603 1.675 -0.838 1.456 -0.996 c 1.35 -1.073 1.231 -1.131 1.105 -1.169 c 0.971 -1.208 0.831 -1.229 0.691 -1.227 c 0.509 -1.227 0.328 -1.191 0.16 -1.121 c 0.007 -1.063 -0.13 -0.972 -0.244 -0.855 c -0.356 -0.73 -0.44 -0.583 -0.491 -0.422 c -0.548 -0.243 -0.576 -0.056 -0.574 0.133 c -0.575 0.313 -0.545 0.493 -0.486 0.664 c -0.426 0.826 -0.335 0.974 -0.22 1.102 c 0.004 1.375 0.338 1.534 0.691 1.535 c 0.883 1.539 1.072 1.495 1.243 1.408 c 1.402 1.326 1.541 1.209 1.649 1.067 c 1.759 0.922 1.838 0.757 1.883 0.582 c 1.932 0.396 1.945 0.203 1.92 0.013 c 0 0.013 l 0 0 l 1.342 0.377 m 1.335 0.468 1.315 0.557 1.283 0.643 c 1.253 0.724 1.209 0.798 1.153 0.863 c 1.097 0.922 1.03 0.97 0.957 1.004 c 0.874 1.043 0.783 1.063 0.691 1.062 c 0.6 1.062 0.509 1.044 0.425 1.009 c 0.345 0.976 0.273 0.926 0.213 0.863 c 0.153 0.799 0.105 0.724 0.072 0.643 c 0.037 0.559 0.017 0.468 0.014 0.377 c 1.355 0.377 l h f Q q 1 0 0 1 422.1581 731.7051 cm 0 0 m -0.012 0.144 -0.082 0.276 -0.194 0.366 c -0.31 0.452 -0.451 0.495 -0.595 0.489 c -0.675 0.488 -0.755 0.476 -0.831 0.452 c -0.918 0.424 -0.998 0.375 -1.062 0.311 c -1.142 0.229 -1.202 0.131 -1.24 0.024 c -1.29 -0.132 -1.312 -0.296 -1.304 -0.459 c -1.304 -0.569 -1.292 -0.677 -1.267 -0.784 c -1.244 -0.885 -1.202 -0.983 -1.145 -1.07 c -1.09 -1.154 -1.016 -1.224 -0.93 -1.275 c -0.833 -1.33 -0.722 -1.356 -0.611 -1.352 c -0.457 -1.357 -0.307 -1.301 -0.194 -1.195 c -0.078 -1.077 -0.005 -0.922 0.011 -0.757 c 0.587 -0.757 l 0.556 -1.055 0.419 -1.332 0.202 -1.538 c -0.022 -1.721 -0.306 -1.815 -0.595 -1.803 c -0.777 -1.806 -0.958 -1.771 -1.126 -1.7 c -1.293 -1.642 -1.445 -1.547 -1.57 -1.421 c -1.68 -1.297 -1.763 -1.151 -1.814 -0.993 c -1.87 -0.822 -1.898 -0.643 -1.896 -0.462 c -1.898 -0.276 -1.871 -0.091 -1.817 0.087 c -1.766 0.252 -1.682 0.405 -1.57 0.537 c -1.459 0.664 -1.323 0.766 -1.168 0.834 c -0.991 0.914 -0.798 0.955 -0.603 0.954 c -0.457 0.954 -0.311 0.935 -0.17 0.895 c -0.039 0.858 0.084 0.799 0.194 0.72 c 0.302 0.643 0.393 0.543 0.459 0.428 c 0.531 0.298 0.572 0.155 0.582 0.008 c 0 0.008 l 0 0 l f Q q 1 0 0 1 423.2177 733.5723 cm 0 0 m 0.577 0 l 0.577 -2.048 l 1.615 -0.985 l 2.322 -0.985 l 1.323 -1.944 l 2.417 -3.604 l 1.716 -3.604 l 0.919 -2.337 l 0.577 -2.669 l 0.577 -3.604 l 0 -3.604 l h f Q q 1 0 0 1 427.0585 732.5762 cm 0 0 m 0.436 0 l 0.436 0.218 l 0.429 0.352 0.448 0.486 0.488 0.614 c 0.521 0.705 0.577 0.786 0.651 0.85 c 0.717 0.905 0.795 0.943 0.879 0.961 c 0.966 0.979 1.056 0.988 1.145 0.988 c 1.28 0.993 1.416 0.981 1.548 0.954 c 1.548 0.505 l 1.509 0.516 1.469 0.523 1.429 0.528 c 1.379 0.532 1.33 0.532 1.28 0.528 c 1.209 0.53 1.14 0.511 1.081 0.473 c 1.019 0.419 0.987 0.337 0.999 0.255 c 0.999 -0.011 l 1.498 -0.011 l 1.498 -0.441 l 1.009 -0.441 l 1.009 -2.622 l 0.436 -2.622 l 0.436 -0.428 l 0.005 -0.428 l 0.005 0 l 0 0 l f Q q 1 0 0 1 430.1 729.8965 cm 0 0 m -0.191 -0.003 -0.381 0.032 -0.559 0.104 c -0.715 0.167 -0.856 0.264 -0.972 0.388 c -1.091 0.512 -1.181 0.659 -1.238 0.82 c -1.356 1.18 -1.356 1.567 -1.238 1.925 c -1.181 2.087 -1.091 2.234 -0.972 2.358 c -0.856 2.481 -0.715 2.578 -0.559 2.643 c -0.199 2.78 0.198 2.78 0.558 2.643 c 0.714 2.578 0.855 2.481 0.972 2.358 c 1.09 2.234 1.181 2.087 1.237 1.925 c 1.355 1.567 1.355 1.18 1.237 0.82 c 1.181 0.659 1.09 0.512 0.972 0.388 c 0.855 0.266 0.713 0.169 0.558 0.106 c 0.38 0.034 0.191 -0.002 0 0 c 0 0.454 m 0.115 0.451 0.23 0.479 0.332 0.534 c 0.424 0.586 0.502 0.659 0.562 0.746 c 0.624 0.836 0.669 0.936 0.695 1.041 c 0.752 1.26 0.752 1.491 0.695 1.71 c 0.669 1.816 0.625 1.916 0.562 2.005 c 0.502 2.091 0.423 2.163 0.332 2.215 c 0.123 2.323 -0.126 2.323 -0.335 2.215 c -0.427 2.163 -0.505 2.091 -0.566 2.005 c -0.628 1.916 -0.673 1.816 -0.699 1.71 c -0.756 1.491 -0.756 1.26 -0.699 1.041 c -0.672 0.936 -0.627 0.836 -0.566 0.746 c -0.506 0.659 -0.427 0.586 -0.335 0.534 c -0.232 0.478 -0.117 0.451 0 0.454 c f Q q 1 0 0 1 431.8979 732.5762 cm 0 0 m 0.531 0 l 0.531 -0.505 l 0.55 -0.43 0.583 -0.359 0.629 -0.297 c 0.681 -0.229 0.74 -0.167 0.807 -0.114 c 0.877 -0.059 0.956 -0.014 1.039 0.019 c 1.123 0.053 1.213 0.07 1.304 0.069 c 1.52 0.069 l 1.52 -0.486 l 1.395 -0.467 l 1.269 -0.467 l 1.178 -0.468 1.087 -0.488 1.004 -0.526 c 0.917 -0.565 0.839 -0.625 0.778 -0.699 c 0.716 -0.783 0.669 -0.878 0.643 -0.98 c 0.604 -1.104 0.584 -1.233 0.586 -1.362 c 0.586 -2.603 l 0.01 -2.603 l 0.01 0 l 0 0 l f Q q 1 0 0 1 437.3666 729.9683 cm 0 0 m -0.577 0 l -0.577 0.364 l -0.649 0.23 -0.759 0.121 -0.893 0.047 c -1.022 -0.029 -1.169 -0.07 -1.32 -0.072 c -1.595 -0.095 -1.866 0.002 -2.064 0.194 c -2.234 0.413 -2.316 0.687 -2.295 0.964 c -2.295 2.608 l -1.719 2.608 l -1.719 1.014 l -1.735 0.843 -1.689 0.67 -1.588 0.531 c -1.492 0.433 -1.357 0.382 -1.219 0.39 c -1.116 0.387 -1.012 0.406 -0.917 0.446 c -0.84 0.479 -0.772 0.531 -0.72 0.595 c -0.667 0.661 -0.63 0.738 -0.611 0.82 c -0.588 0.911 -0.577 1.003 -0.577 1.097 c -0.577 2.611 l 0 2.611 l 0 0 l f Q q 1 0 0 1 437.9877 732.5762 cm 0 0 m 0.545 0 l 0.545 -0.353 l 0.617 -0.209 0.736 -0.094 0.882 -0.026 c 1.03 0.04 1.19 0.073 1.352 0.072 c 1.535 0.075 1.717 0.038 1.883 -0.037 c 2.031 -0.106 2.161 -0.208 2.263 -0.334 c 2.366 -0.465 2.442 -0.615 2.489 -0.775 c 2.54 -0.948 2.566 -1.127 2.566 -1.307 c 2.566 -1.479 2.542 -1.651 2.497 -1.817 c 2.455 -1.973 2.385 -2.121 2.29 -2.252 c 2.099 -2.522 1.789 -2.682 1.458 -2.68 c 1.369 -2.681 1.28 -2.674 1.193 -2.659 c 1.11 -2.644 1.028 -2.618 0.951 -2.584 c 0.875 -2.552 0.802 -2.509 0.736 -2.457 c 0.671 -2.406 0.615 -2.343 0.571 -2.273 c 0.571 -3.575 l -0.005 -3.575 l -0.005 0 l 0 0 l 2.008 -1.307 m 2.008 -1.191 1.993 -1.076 1.963 -0.964 c 1.936 -0.859 1.89 -0.759 1.828 -0.669 c 1.768 -0.584 1.69 -0.514 1.599 -0.462 c 1.503 -0.409 1.395 -0.382 1.286 -0.385 c 1.072 -0.372 0.867 -0.467 0.738 -0.638 c 0.607 -0.836 0.543 -1.072 0.555 -1.31 c 0.554 -1.433 0.57 -1.557 0.603 -1.676 c 0.631 -1.781 0.68 -1.879 0.747 -1.965 c 0.809 -2.044 0.886 -2.109 0.975 -2.157 c 1.071 -2.206 1.178 -2.23 1.286 -2.229 c 1.401 -2.232 1.517 -2.205 1.618 -2.148 c 1.708 -2.096 1.785 -2.025 1.843 -1.939 c 1.903 -1.85 1.945 -1.751 1.968 -1.646 c 1.995 -1.535 2.008 -1.421 2.008 -1.307 c f Q q 1 0 0 1 443.5127 729.9683 cm 0 0 m -0.545 0 l -0.545 0.353 l -0.616 0.211 -0.734 0.099 -0.879 0.034 c -1.027 -0.031 -1.187 -0.065 -1.349 -0.064 c -1.532 -0.067 -1.714 -0.03 -1.88 0.045 c -2.028 0.113 -2.158 0.214 -2.26 0.34 c -2.364 0.47 -2.441 0.62 -2.486 0.781 c -2.538 0.958 -2.564 1.143 -2.563 1.328 c -2.568 1.536 -2.536 1.742 -2.468 1.938 c -2.41 2.097 -2.319 2.242 -2.202 2.364 c -2.101 2.471 -1.977 2.555 -1.838 2.608 c -1.705 2.659 -1.563 2.685 -1.421 2.685 c -1.338 2.685 -1.256 2.678 -1.174 2.664 c -1.091 2.648 -1.01 2.624 -0.932 2.589 c -0.855 2.556 -0.783 2.514 -0.717 2.462 c -0.652 2.411 -0.597 2.349 -0.553 2.279 c -0.553 3.606 l 0.024 3.606 l 0.024 0 l 0 0 l -2.008 1.277 m -2.009 1.166 -1.994 1.056 -1.965 0.948 c -1.939 0.845 -1.896 0.748 -1.835 0.661 c -1.777 0.578 -1.699 0.508 -1.61 0.459 c -1.404 0.355 -1.162 0.355 -0.956 0.459 c -0.866 0.512 -0.789 0.585 -0.73 0.671 c -0.671 0.762 -0.626 0.862 -0.6 0.966 c -0.572 1.076 -0.558 1.188 -0.558 1.301 c -0.543 1.542 -0.612 1.781 -0.751 1.979 c -0.88 2.14 -1.078 2.229 -1.283 2.22 c -1.402 2.224 -1.52 2.196 -1.623 2.138 c -1.714 2.083 -1.793 2.009 -1.852 1.92 c -1.911 1.828 -1.954 1.725 -1.977 1.617 c -1.999 1.505 -2.01 1.392 -2.008 1.277 c f Q q 1 0 0 1 446.3252 730.5499 cm 0 0 m -0.004 -0.052 0.005 -0.104 0.026 -0.151 c 0.052 -0.185 0.094 -0.202 0.136 -0.197 c 0.197 -0.197 l 0.223 -0.2 0.25 -0.2 0.276 -0.197 c 0.276 -0.595 l 0.199 -0.619 l 0.101 -0.64 l 0 -0.656 l -0.085 -0.656 l -0.187 -0.66 -0.288 -0.635 -0.377 -0.584 c -0.461 -0.528 -0.516 -0.437 -0.528 -0.337 c -0.648 -0.451 -0.792 -0.534 -0.951 -0.579 c -1.106 -0.628 -1.269 -0.654 -1.432 -0.656 c -1.546 -0.657 -1.659 -0.641 -1.769 -0.608 c -1.872 -0.579 -1.967 -0.531 -2.053 -0.468 c -2.136 -0.405 -2.203 -0.324 -2.25 -0.231 c -2.3 -0.127 -2.326 -0.012 -2.324 0.104 c -2.33 0.24 -2.299 0.375 -2.236 0.497 c -2.181 0.594 -2.101 0.675 -2.005 0.733 c -1.905 0.791 -1.795 0.833 -1.681 0.855 c -1.562 0.88 -1.442 0.899 -1.32 0.914 c -1.222 0.933 -1.123 0.947 -1.022 0.956 c -0.938 0.963 -0.855 0.977 -0.773 0.999 c -0.708 1.014 -0.649 1.046 -0.6 1.092 c -0.556 1.144 -0.533 1.211 -0.536 1.28 c -0.534 1.344 -0.553 1.408 -0.59 1.46 c -0.624 1.507 -0.668 1.544 -0.72 1.569 c -0.775 1.596 -0.834 1.613 -0.895 1.62 c -0.955 1.624 -1.016 1.624 -1.076 1.62 c -1.215 1.625 -1.354 1.591 -1.474 1.519 c -1.581 1.45 -1.647 1.333 -1.652 1.206 c -2.231 1.206 l -2.227 1.354 -2.185 1.498 -2.108 1.625 c -2.041 1.733 -1.951 1.824 -1.843 1.891 c -1.729 1.96 -1.603 2.007 -1.472 2.032 c -1.329 2.072 -1.183 2.098 -1.036 2.109 c -0.908 2.109 -0.781 2.096 -0.656 2.069 c -0.538 2.044 -0.425 2 -0.321 1.939 c -0.225 1.88 -0.143 1.8 -0.083 1.705 c -0.02 1.599 0.012 1.478 0.008 1.354 c 0.008 0.013 l 0 0 l -0.576 0.728 m -0.674 0.667 -0.785 0.631 -0.9 0.624 c -1.028 0.612 -1.155 0.594 -1.283 0.571 c -1.343 0.561 -1.402 0.547 -1.46 0.528 c -1.515 0.511 -1.566 0.485 -1.612 0.451 c -1.657 0.419 -1.692 0.376 -1.716 0.327 c -1.742 0.267 -1.755 0.203 -1.753 0.138 c -1.755 0.079 -1.735 0.021 -1.697 -0.024 c -1.661 -0.067 -1.615 -0.103 -1.564 -0.127 c -1.509 -0.154 -1.451 -0.171 -1.392 -0.181 c -1.335 -0.19 -1.278 -0.196 -1.222 -0.197 c -1.152 -0.196 -1.083 -0.188 -1.015 -0.173 c -0.94 -0.156 -0.87 -0.127 -0.805 -0.088 c -0.74 -0.048 -0.684 0.004 -0.64 0.066 c -0.594 0.134 -0.571 0.215 -0.574 0.297 c -0.574 0.725 l h f Q q 1 0 0 1 446.6836 732.5762 cm 0 0 m 0.434 0 l 0.434 0.784 l 0.996 0.784 l 0.996 0 l 1.527 0 l 1.527 -0.43 l 0.996 -0.43 l 0.996 -1.822 l 0.993 -1.874 0.993 -1.927 0.996 -1.979 c 1 -2.018 1.011 -2.056 1.031 -2.09 c 1.05 -2.122 1.079 -2.146 1.113 -2.159 c 1.162 -2.177 1.213 -2.185 1.265 -2.183 c 1.387 -2.183 l 1.428 -2.181 1.469 -2.175 1.509 -2.165 c 1.509 -2.608 l 1.323 -2.629 l 1.261 -2.633 1.199 -2.633 1.137 -2.629 c 1.013 -2.633 0.89 -2.619 0.771 -2.587 c 0.688 -2.564 0.613 -2.52 0.553 -2.459 c 0.499 -2.4 0.462 -2.328 0.446 -2.25 c 0.427 -2.155 0.416 -2.059 0.415 -1.963 c 0.415 -0.428 l -0.019 -0.428 l -0.019 0 l 0 0 l f Q q 1 0 0 1 449.0742 731.1235 cm 0 0 m 0 -0.099 0.014 -0.198 0.042 -0.292 c 0.068 -0.382 0.112 -0.466 0.17 -0.54 c 0.229 -0.611 0.303 -0.669 0.388 -0.709 c 0.486 -0.754 0.593 -0.776 0.701 -0.773 c 0.845 -0.78 0.987 -0.742 1.107 -0.664 c 1.216 -0.582 1.296 -0.468 1.336 -0.337 c 1.88 -0.337 l 1.827 -0.603 1.674 -0.838 1.456 -0.996 c 1.349 -1.073 1.231 -1.131 1.105 -1.169 c 0.973 -1.208 0.836 -1.228 0.699 -1.227 c 0.512 -1.23 0.327 -1.196 0.154 -1.126 c 0.003 -1.066 -0.133 -0.973 -0.244 -0.855 c -0.356 -0.73 -0.44 -0.583 -0.491 -0.422 c -0.548 -0.243 -0.576 -0.056 -0.574 0.133 c -0.575 0.313 -0.546 0.493 -0.486 0.664 c -0.426 0.826 -0.336 0.974 -0.221 1.102 c 0.002 1.374 0.334 1.532 0.685 1.535 c 0.877 1.539 1.067 1.495 1.238 1.408 c 1.396 1.326 1.535 1.209 1.644 1.067 c 1.753 0.922 1.833 0.757 1.878 0.582 c 1.927 0.396 1.939 0.203 1.915 0.013 c -0.002 0.013 l 0 0 l 1.341 0.377 m 1.335 0.468 1.315 0.557 1.283 0.643 c 1.253 0.724 1.209 0.798 1.153 0.863 c 1.096 0.926 1.027 0.978 0.951 1.014 c 0.868 1.054 0.777 1.074 0.685 1.073 c 0.594 1.073 0.504 1.055 0.419 1.02 c 0.339 0.986 0.267 0.937 0.207 0.874 c 0.147 0.81 0.099 0.735 0.066 0.653 c 0.031 0.569 0.011 0.479 0.008 0.388 c 1.349 0.388 l h f Q q 1 0 0 1 451.8657 730.7994 cm 0 0 m 0.002 -0.142 0.073 -0.274 0.191 -0.353 c 0.312 -0.423 0.45 -0.458 0.59 -0.454 c 0.651 -0.458 0.711 -0.458 0.773 -0.454 c 0.839 -0.447 0.904 -0.43 0.967 -0.406 c 1.024 -0.385 1.075 -0.349 1.116 -0.303 c 1.155 -0.252 1.174 -0.189 1.168 -0.125 c 1.166 -0.057 1.138 0.008 1.089 0.056 c 1.033 0.107 0.967 0.146 0.895 0.17 c 0.809 0.201 0.72 0.226 0.629 0.245 c 0.329 0.33 l 0.224 0.352 0.121 0.38 0.019 0.415 c -0.076 0.446 -0.166 0.491 -0.247 0.55 c -0.327 0.608 -0.391 0.683 -0.436 0.771 c -0.486 0.873 -0.511 0.986 -0.507 1.1 c -0.512 1.226 -0.475 1.351 -0.404 1.456 c -0.333 1.551 -0.243 1.63 -0.138 1.687 c -0.028 1.747 0.092 1.788 0.215 1.809 c 0.337 1.832 0.462 1.843 0.587 1.843 c 0.716 1.844 0.845 1.83 0.972 1.801 c 1.09 1.774 1.202 1.727 1.304 1.663 c 1.404 1.598 1.488 1.513 1.551 1.413 c 1.621 1.3 1.663 1.173 1.676 1.041 c 1.076 1.041 l 1.059 1.155 0.989 1.253 0.887 1.307 c 0.78 1.355 0.665 1.38 0.547 1.378 c 0.5 1.381 0.452 1.381 0.403 1.378 c 0.35 1.373 0.298 1.36 0.247 1.341 c 0.2 1.325 0.157 1.297 0.122 1.262 c 0.087 1.224 0.069 1.174 0.071 1.124 c 0.069 1.058 0.096 0.995 0.146 0.951 c 0.202 0.903 0.267 0.866 0.337 0.842 c 0.424 0.811 0.512 0.786 0.603 0.768 c 0.917 0.701 l 1.021 0.678 1.124 0.65 1.224 0.616 c 1.319 0.584 1.409 0.539 1.49 0.481 c 1.662 0.359 1.762 0.16 1.755 -0.05 c 1.76 -0.189 1.723 -0.326 1.649 -0.443 c 1.582 -0.551 1.491 -0.642 1.384 -0.709 c 1.267 -0.778 1.14 -0.827 1.007 -0.855 c 0.873 -0.885 0.735 -0.9 0.598 -0.9 c 0.443 -0.902 0.29 -0.883 0.141 -0.845 c 0.01 -0.812 -0.114 -0.753 -0.223 -0.674 c -0.324 -0.601 -0.407 -0.504 -0.465 -0.393 c -0.527 -0.269 -0.559 -0.131 -0.558 0.008 c 0.019 0.008 l 0 0 l f Q 0.146 0.941 0.992 0.044 k q 1 0 0 1 401.2527 729.3892 cm 0 0 m 3.612 2.406 l 3.612 5.296 l 0 5.296 l h f Q 0 0.889 0.676 0 k q 1 0 0 1 404.865 729.3892 cm 0 0 m -3.612 2.406 l -3.612 5.296 l 0 5.296 l h f Q 0.694 0.076 0.209 0 k q 1 0 0 1 403.0589 735.3145 cm 0 0 m -2.2 0 -3.984 -1.784 -3.984 -3.984 c -3.984 -6.184 -2.2 -7.968 0 -7.968 c 2.2 -7.968 3.984 -6.184 3.984 -3.984 c 3.984 -1.784 2.2 0 0 0 c 0 -6.993 m -1.662 -6.993 -3.009 -5.646 -3.009 -3.984 c -3.009 -2.322 -1.662 -0.975 0 -0.975 c 1.662 -0.975 3.009 -2.322 3.009 -3.984 c 3.009 -5.646 1.662 -6.993 0 -6.993 c f Q 0 0.235 0.86 0 k q 1 0 0 1 405.2601 729.2803 cm 0 0 m -1.118 -1.208 -3.015 -1.281 -4.237 -0.159 c -5.159 0.688 -5.459 2.005 -4.999 3.156 c -5.833 3.687 l -6.736 1.681 -5.843 -0.679 -3.836 -1.582 c -2.218 -2.311 -0.312 -1.881 0.836 -0.528 c 0 0 l f Q 0 0 0 0.6 k q 1 0 0 1 397.4813 736.8087 cm 0 0 m -0.238 0 -0.432 -0.193 -0.432 -0.432 c -0.432 -10.524 l -0.432 -10.763 -0.238 -10.956 0 -10.956 c 57.901 -10.956 l 58.139 -10.956 58.333 -10.763 58.333 -10.524 c 58.333 -0.432 l 58.333 -0.193 58.139 0 57.901 0 c h 57.901 -11.155 m 0 -11.155 l -0.348 -11.155 -0.631 -10.872 -0.631 -10.524 c -0.631 -0.432 l -0.631 -0.084 -0.348 0.199 0 0.199 c 57.901 0.199 l 58.249 0.199 58.532 -0.084 58.532 -0.432 c 58.532 -10.524 l 58.532 -10.872 58.249 -11.155 57.901 -11.155 c f Q EMC Q endstream endobj 2183 0 obj <> endobj 2190 0 obj <>stream Adobe Illustrator CS6 (Windows) 2021-04-12T11:45:36+05:00 2021-06-02T10:28:09+05:00 2021-06-02T10:28:09+05:00 1 False False 20.868494 3.999928 Millimeters Cyan Magenta Yellow Black Default Swatch Group 0 C=0 M=24 Y=86 K=0 PROCESS 100.000000 CMYK 0.000000 23.504999 86.022697 0.000000 C=69 M=8 Y=21 K=0 PROCESS 100.000000 CMYK 69.369003 7.635600 20.892700 0.000000 C=0 M=89 Y=68 K=0 PROCESS 100.000000 CMYK 0.000000 88.946404 67.623398 0.000000 C=15 M=94 Y=99 K=4 PROCESS 100.000000 CMYK 14.578501 94.070297 99.160698 4.416000 C=0 M=0 Y=0 K=84 PROCESS 100.000000 CMYK 0.000000 0.000000 0.000000 84.000000 C=0 M=0 Y=0 K=35 PROCESS 100.000000 CMYK 0.000000 0.000000 0.000000 35.000000 C=0 M=0 Y=0 K=60 PROCESS 100.000000 CMYK 0.000000 0.000000 0.000000 60.000004 Document application/pdf proof:pdf xmp.did:804244B35A9BEB118A6FC3C256996E2F uuid:08e30110-bdb7-4606-97ca-63fb62cbcecc uuid:21079f76-f6d7-4329-b725-f2fb35af5114 uuid:722f8893-0b3c-4402-87fb-c713f1fa0e26 uuid:21079f76-f6d7-4329-b725-f2fb35af5114 uuid:21079f76-f6d7-4329-b725-f2fb35af5114 proof:pdf saved xmp.iid:804244B35A9BEB118A6FC3C256996E2F 2021-04-12T11:45:42+05:00 Adobe Illustrator CS6 (Windows) / endstream endobj 2189 0 obj <>/Border[0 0 0]/H/N/Rect[394.85 739.008 458.005 723.67]/Subtype/Link/Type/Annot>> endobj 2191 0 obj <> endobj 2179 0 obj [2192 0 R 2193 0 R 2194 0 R 2195 0 R 2196 0 R 2197 0 R 2198 0 R 2199 0 R 2200 0 R 2201 0 R 2202 0 R 2203 0 R 2204 0 R 2205 0 R] endobj 2180 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\210\013\n)-10(\026)11(\025\002\020 \002\220\006\n\013 \222\013\r\025\002\025\026)11(\013 \006\220\202)10(\024\025\r\220\201\001\025\203 \n\220\n\220 \215\022\221\013\227\220\016\ \001\026)11(\025\r )]TJ 0 -1 TD [(\006\022\220\201\220\025\221\013\026\220\017\016\006\n\220\024 \024\016\202\ )10.1(\013\n)10(\025\007\025\001/\024\016\202)10(\013\002\016\n)-9.9(\026)-20(\215\024)]TJ 33.279 1 Td [(Risk factor)20(s of sigmoid v)10(olv)10(ulus in patients with idiopathic megacolon)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0.07 Tw 8 0 0 8 42.5197 731.2159 Tm (9.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Ak)-16(inkuo)17.1(tu)]TJ /Span<>> BDC ( )Tj EMC (A, Samuel)Tj /Span<>> BDC ( )Tj EMC [(JC, Msisk)-17(a)]TJ /Span<>> BDC ( )Tj EMC [(N, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. T)47(he r)-32(ole of t)-13(he ana)15(t)17(omy )]TJ 0.067 Tw -1.296 -1.25 Td [(of t)-13(he sigmoid col)30(on in devel)30(oping sigmoid vol)30(vul)35(us: a case-contr)-31.9(ol )]TJ 0 Tw 0 -1.25 TD [(stud)17(y. )]TJ /T1_2 1 Tf 0.023 Tw 2.739 0 Td (Clin Anat.)Tj /T1_1 1 Tf [( 2011;24:634\226637. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1002/ca.21131)Tj 0 0 0 1 k /GS1 gs 0.006 Tc 0.35 Tw -2.739 -1.25 Td (10.)Tj /Span<>> BDC ( )Tj EMC 1.822 0 Td [(Br)-37.3(ian WC)19.6(A T)34.7(ian, V)-15.4(igut)-30.4(t)16.7(o)]TJ /Span<>> BDC ( )Tj EMC [(G, T)39.6(an)]TJ /Span<>> BDC ( )Tj EMC [(E, e)-12.4(t)]TJ /Span<>> BDC ( )Tj EMC [(al. WSES consensus)6( )]TJ 0 Tc 0.189 Tw -1.822 -1.25 Td [(guidel)-31(ines on sigmoid vol)30(vul)35(us mana)-17(gement. )]TJ /T1_2 1 Tf [(W)29(orld J Emerg Surg.)]TJ /T1_1 1 Tf 0 Tw ( )Tj 0.023 Tw T* [(2023;15;18\(1\):34. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1186/s13017-023-00502-x)Tj 0 0 0 1 k /GS1 gs 0.006 Tc 0.35 Tw T* (11.)Tj /Span<>> BDC ( )Tj EMC 1.82 0 Td (Swenson)Tj /Span<>> BDC ( )Tj EMC 4.117 0 Td [(BR, )0.5(K)20(w)-11.9(aan)]TJ /Span<>> BDC ( )Tj EMC 5.068 0 Td [(MR, )0.5(Bur)-24(k)-17(ar)-22(t)]TJ /Span<>> BDC ( )Tj EMC 5.635 0 Td [(NE, )0.6(e)-12(t)]TJ /Span<>> BDC ( )Tj EMC 3.295 0 Td [(al. )0.5(Col)30(onic )0.5(vol)30(vu)]TJ 0 Tc 0 Tw (-)Tj 0.008 Tc 0.35 Tw -19.935 -1.25 Td [(l)34.7(us: p)24.7(r)-24.2(esent)14.7(a)14.7(t)-32.3(ion and mana)-17.3(gement in me)-12.3(tr)-32.3(opol)-31.3(i)-24.3(t)14.7(an Minneso)16.7(t)14.7(a,)8( )]TJ 0 Tc 0.179 Tw T* [(U)13(ni)-24(ted S)15(t)15(a)15(tes. )]TJ /T1_2 1 Tf [(Dis Colon R)21(ectum. )]TJ /T1_1 1 Tf [(2012;55:444\226449. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1097/)Tj T* (DCR.0b013e3182404b3d)Tj 0 0 0 1 k /GS1 gs 0.129 Tw T* (12.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(G)20(r)-32(oss)26(mann)]TJ /Span<>> BDC ( )Tj EMC [(EM, L)35(ongo)]TJ /Span<>> BDC ( )Tj EMC [(WE, S)15(tr)-32.9(a)14.9(t)-29.9(t)17(on)]TJ /Span<>> BDC ( )Tj EMC [(MD, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. S)-16(igmoid vol)30(vul)35.1(us )]TJ 0.022 Tw -1.796 -1.25 Td [(in Dep)32(ar)-22(tment of V)30.1(e)-12(ter)-33(ans Af)-56(f)16(air)-9.9(s Medical Center)-10(s. )]TJ /T1_2 1 Tf [(Dis Colon R)21(ectum. )]TJ /T1_1 1 Tf 0.023 Tw T* [(2000;43:414\226418. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1007/BF02258311)Tj 0 0 0 1 k /GS1 gs 0.001 Tw T* (13.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(T)40(an)]TJ /Span<>> BDC ( )Tj EMC (KK, Chong)Tj /Span<>> BDC ( )Tj EMC [(CS, S)-16(im)]TJ /Span<>> BDC ( )Tj EMC [(R. Mana)-17(gement of a)-17(cute sigmoid vol)30(vul)35(us: )]TJ -0.033 Tw -1.796 -1.25 Td [(an inst)-31.9(i)-24(tut)-32(ion\245s )0.5(e)-18(xper)-37(ience )0.5(over 9 year)-9.9(s. )]TJ /T1_2 1 Tf [(W)29(orld )0.5(J Surg. )]TJ /T1_1 1 Tf 0 Tw (2010;34:1943\226)Tj 0.023 Tw T* [(1948. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1007/s00268-010-0563-8)Tj 0 0 0 1 k /GS1 gs 0.014 Tw T* (14.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(L)-32(ar)-24(k)-15.9(in)]TJ /Span<>> BDC ( )Tj EMC 2.785 0 Td [(J)25(O, )0.5(T)47(hek)-16(iso)]TJ /Span<>> BDC ( )Tj EMC 4.691 0 Td [(TB, )0.5(W)12(aldr)-32(on)]TJ /Span<>> BDC ( )Tj EMC 4.965 0 Td [(R, )0.5(e)-12(t)]TJ /Span<>> BDC ( )Tj EMC 2.036 0 Td [(al. )0.5(R)13(ecur)-23.9(r)-24(ent )0.5(sigmoid )0.5(vol)30(vu)]TJ 0 Tw (-)Tj 0.061 Tw -16.273 -1.25 Td [(l)35(us-ear)-29.9(l)35(y r)-24(esec)-15.9(t)-32(ion ma)15(y obv)-16(ia)15(te l)-16(a)15(ter emer)-31.9(gency sur)-32(ger)-24(y and r)-24(educe )]TJ 0.201 Tw T* [(mor)-24(bidi)-23.9(t)-10(y and mor)-22(t)15.1(al)-31(i)-24(t)-10(y. )]TJ /T1_2 1 Tf [(Ann R Coll Surg Eng)13(l. )]TJ /T1_1 1 Tf 0 Tw (2009;91:205\226209. )Tj T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1308/003588409X391776)Tj 0 0 0 1 k /GS1 gs 0.26 Tw 27.208 23.75 Td (15.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Mul)-16(as)]TJ /Span<>> BDC ( )Tj EMC [(C, Br)-22(una)]TJ /Span<>> BDC ( )Tj EMC [(M, Gar)-32(c)-23.9(ia-Ar)-16(mengol)]TJ /Span<>> BDC ( )Tj EMC [(J, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Mana)-17(gement of )]TJ 0.252 Tw -1.796 -1.25 Td [(col)30(onic )0.6(vol)30(vul)35(us. )0.6(E)35(xper)-37(ience )0.6(in )0.6(75 )0.5(p)32(a)15(t)-32(ients. )]TJ /T1_2 1 Tf 19.154 0 Td [(R)21(ev )0.6(Esp )0.5(Enfer)-14(m )0.6(Dig. )]TJ /T1_1 1 Tf 0.023 Tw -19.154 -1.25 Td [(2010;102:239\226248. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.4321/S1130-01082010000400004)Tj 0 0 0 1 k /GS1 gs 0.028 Tw T* (16.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Ak)-16(inkuo)17.1(tu)]TJ /Span<>> BDC ( )Tj EMC (A, Samuel)Tj /Span<>> BDC ( )Tj EMC [(JC, Msisk)-17(a)]TJ /Span<>> BDC ( )Tj EMC [(N, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. T)47(he r)-31.9(ole of t)-12.9(he ana)15(t)17(omy )]TJ 0.067 Tw -1.796 -1.25 Td [(of t)-13(he sigmoid col)30(on in devel)30(oping sigmoid vol)30(vul)35(us: a case-contr)-31.9(ol )]TJ 0 Tw T* [(stud)17(y. )]TJ /T1_2 1 Tf 0.023 Tw 2.739 0 Td (Clin Anat. )Tj /T1_1 1 Tf [(2011;24:634\226637. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1002/ca.21131)Tj 0 0 0 1 k /GS1 gs 0.196 Tw -2.739 -1.25 Td (17.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(A)-25(chk)-17(asov)]TJ /Span<>> BDC ( )Tj EMC [(S.I. Anomal)-30.9(ies of t)-13(he devel)30(opment and posi)-24(t)-32(ion of )]TJ 0.247 Tw -1.796 -1.25 Td [(t)-13(he col)30(on. Cl)-31(inic, dia)-17(gnosis, tr)-24(ea)15(tment. Diss\246 Do)-16(c)-16(t)17(or of Medical )]TJ 0.023 Tw T* [(S)-24(c)-24(iences, M)-24(osco)-14(w, 2003, p. 294. \(in Russ.\).)]TJ 0.074 Tw T* (18.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Aleshin)Tj /Span<>> BDC ( )Tj EMC 3.292 0 Td [(D.V., )0.6(A)-25(chk)-17(asov)]TJ /Span<>> BDC ( )Tj EMC 6.241 0 Td [(S.I., )0.6(S)-16(hakhma)15(t)17(ov)]TJ /Span<>> BDC ( )Tj EMC 7.102 0 Td [(D.G., )0.6(e)-12(t)]TJ /Span<>> BDC ( )Tj EMC 3.314 0 Td [(al. )0.6(T)47(he )0.5(qual)-31(i)-23.9(t)-10(y )]TJ 0.176 Tw -21.745 -1.25 Td [(of l)-31(ife )0.5(of p)32(a)15(t)-32(ients )0.5(wi)-24(t)-13(h )0.5(idiop)32(a)15(t)-13(hic mega)-16.9(col)30(on and i)-24(ts )0.5(r)-24(el)-16(a)15(t)-32(ionship )]TJ 0.075 Tw T* [(wi)-24(t)-12.9(h cl)-30.9(inical sym)10(pt)17(oms and dia)-17(gnost)-32(ic test r)-24(esul)56(ts. )]TJ /T1_2 1 Tf 0 Tw [(K)17.9(olop)46.1(roktologia)]TJ /T1_1 1 Tf (. )Tj 0.204 Tw T* [(2023;2\(84\):40\22648. \(in Russ.\). d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.33878/2073-7556-2023-22-)Tj T* (2-40-48)Tj 0 0 0 1 k /GS1 gs 0.17 Tw T* (19.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(P)30(er)-24(r)-31.9(o)17(t)]TJ /Span<>> BDC ( )Tj EMC [(L, F)10(ohlen)]TJ /Span<>> BDC ( )Tj EMC [(A, Al)30(ves)]TJ /Span<>> BDC ( )Tj EMC [(A, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Mana)-16.9(gement of t)-12.9(he col)30(onic )]TJ 0.041 Tw -1.796 -1.25 Td [(vol)30(vul)35.1(us in 2016. )]TJ /T1_2 1 Tf (J Visc Surg. )Tj /T1_1 1 Tf [(2016;153\(3\):183\226192. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1016/j.)Tj T* [(jv)-16(iscsur)-31.9(g.2016.03.006)]TJ 0 0 0 1 k /GS1 gs 0.013 Tw T* (20.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Madiba)Tj /Span<>> BDC ( )Tj EMC 3.118 0 Td [(TE, )0.5(Haf)-56(f)16(ajee)]TJ /Span<>> BDC ( )Tj EMC [(MR. )0.5(S)-16(igmoid )0.5(col)30(on mor)-24(phol)30.1(o)-16(g)16(y in )0.5(t)-13(he popu)]TJ 0 Tw (-)Tj 0.048 Tw -4.914 -1.25 Td [(l)-16(a)15(t)-32(ion gr)-32(oups of Dur)-23.9(ban, S)-15.9(out)-13(h Afr)-37(ica, wi)-24(t)-12.9(h spec)-24(ial r)-24(efer)-24(ence t)17.1(o sig)]TJ 0 Tw (-)Tj 0.023 Tw T* [(moid vol)30.1(vul)35(us. )]TJ /T1_2 1 Tf (Clin Anat. )Tj /T1_1 1 Tf [(2011;24:441\226453. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1002/ca.21100)Tj /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\033\030\031\030\213\b)-20.9(\035\231\213\233\t \021\032)50(\b)42(\032\231\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj /T1_3 1 Tf 25 0 0 25 512.0771 56.0378 Tm (41)Tj ET endstream endobj 2192 0 obj <>/Border[0 0 0]/H/N/Rect[173.81 718.512 233.29 709.056]/Subtype/Link/Type/Annot>> endobj 2193 0 obj <>/Border[0 0 0]/H/N/Rect[118.98 688.512 216.003 679.216]/Subtype/Link/Type/Annot>> endobj 2194 0 obj <>/Border[0 0 0]/H/N/Rect[233.71 658.512 263.622 649.056]/Subtype/Link/Type/Annot>> endobj 2195 0 obj <>/Border[0 0 0]/H/N/Rect[42.5197 648.512 121.023 639.216]/Subtype/Link/Type/Annot>> endobj 2196 0 obj <>/Border[0 0 0]/H/N/Rect[119.02 618.512 188.708 609.216]/Subtype/Link/Type/Annot>> endobj 2197 0 obj <>/Border[0 0 0]/H/N/Rect[77.716 588.512 171.188 579.216]/Subtype/Link/Type/Annot>> endobj 2198 0 obj <>/Border[0 0 0]/H/N/Rect[57.2978 548.512 151.058 539.216]/Subtype/Link/Type/Annot>> endobj 2199 0 obj <>/Border[0 0 0]/H/N/Rect[355.461 718.512 475.893 709.216]/Subtype/Link/Type/Annot>> endobj 2200 0 obj <>/Border[0 0 0]/H/N/Rect[406.251 688.512 465.731 679.056]/Subtype/Link/Type/Annot>> endobj 2201 0 obj <>/Border[0 0 0]/H/N/Rect[394.887 618.512 496.063 609.216]/Subtype/Link/Type/Annot>> endobj 2202 0 obj <>/Border[0 0 0]/H/N/Rect[274.961 608.512 300.592 599.216]/Subtype/Link/Type/Annot>> endobj 2203 0 obj <>/Border[0 0 0]/H/N/Rect[461.551 588.512 496.063 579.056]/Subtype/Link/Type/Annot>> endobj 2204 0 obj <>/Border[0 0 0]/H/N/Rect[274.961 578.512 346.848 569.216]/Subtype/Link/Type/Annot>> endobj 2205 0 obj <>/Border[0 0 0]/H/N/Rect[432.933 548.512 492.412 539.056]/Subtype/Link/Type/Annot>> endobj 2219 0 obj <> endobj 2218 0 obj <> endobj 2217 0 obj <> endobj 2216 0 obj <> endobj 2215 0 obj <> endobj 2214 0 obj <> endobj 2213 0 obj <> endobj 2212 0 obj <> endobj 2211 0 obj <> endobj 2210 0 obj <> endobj 2209 0 obj <> endobj 2208 0 obj <> endobj 2207 0 obj <> endobj 2206 0 obj <> endobj 2108 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 2109 0 obj <>/Font<>/ProcSet[/PDF/Text/ImageC]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 2110 0 obj <>/Font<>/ProcSet[/PDF/Text/ImageB]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 2111 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 2112 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 2226 0 obj [2228 0 R 2229 0 R 2230 0 R 2231 0 R 2232 0 R 2233 0 R 2234 0 R 2235 0 R 2236 0 R 2237 0 R 2238 0 R 2239 0 R 2240 0 R 2241 0 R 2242 0 R 2243 0 R 2244 0 R 2245 0 R 2246 0 R 2247 0 R 2248 0 R 2249 0 R 2250 0 R 2251 0 R 2252 0 R 2253 0 R 2254 0 R 2255 0 R 2256 0 R 2257 0 R] endobj 2227 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.877 Tw 10 0 0 10 70.8661 724.8299 Tm [(S)7(t)-27.7(a)-8.4(t)-37.4(i)2.7(s)-20(t)-37.3(i)5.2(c)-11.8(a)-1.5(l d)0.7(a)-8.4(t)-27.7(a p)-3.8(r)-5.9(o)-7.1(ce)-13.3(s)-12.8(s)-16.6(i)7.1(n)-1.9(g)9(:)]TJ /T1_1 1 Tf [( D)-6.1(e)-2.6(n)6.2(i)11(s)]TJ /Span<>> BDC ( )Tj EMC [(V)53.1(.)]TJ /Span<>> BDC ( )Tj EMC [(A)3.6(l)4.8(e)-18(s)9.6(h)6.2(i)8.4(n)-6(, )]TJ 0 Tw 0 -1.218 TD [(M)5.2(ar)-35.3(i)5.9(a)]TJ /Span<>> BDC ( )Tj EMC [(A)-12.5(.)]TJ /Span<>> BDC ( )Tj EMC [(I)10(g)1.9(n)4.8(a)-4.9(t)2.8(e)-2.6(n)7.5(k)13(o)-3.7(, A)3.6(l)4.8(ek)-17.5(s)4.9(e)-2.5(y)]TJ /Span<>> BDC ( )Tj EMC [(A)-12.6(.)]TJ /Span<>> BDC ( )Tj EMC [(P)25.1(on)1.9(om)4.3(ar)2.4(e)-2.6(n)7.5(k)13(o)]TJ /T1_0 1 Tf 0.006 Tc -0.006 Tw T* [(E)11.6(dit)-31.4(i)13.1(n)4.1(g)15(:)]TJ /T1_1 1 Tf 0 Tc 0.811 Tw 3.238 0 Td [( S)5.6(e)-1.7(r)2.4(g)-2.5(e)-2.5(y)]TJ /Span<>> BDC ( )Tj EMC [(I)2.4(.)]TJ /Span<>> BDC ( )Tj EMC 6.328 0 Td [(A)0.9(c)1.8(h)7.5(k)15.8(a)-3(s)5(o)-0.6(v)33.6(, O)-7.4(l)4.8(e)-3.5(g)]TJ /Span<>> BDC ( )Tj EMC 7.572 0 Td [(I)2.4(.)]TJ /Span<>> BDC ( )Tj EMC 1.674 0 Td [(S)15.8(us)9.6(h)7.5(k)12.9(o)-0.6(v)33.6(, )]TJ 0.908 Tw -18.812 -1.218 Td [(D)-2(m)5.8(i)0.9(t)-5.4(r)-35.3(iy)]TJ /Span<>> BDC ( )Tj EMC [(G)-1.4(.)]TJ /Span<>> BDC ( )Tj EMC 5.979 0 Td [(S)15.3(h)4.8(a)1.7(k)5.3(h)5.2(m)4.3(a)-4.8(t)1.4(o)-0.6(v)33.6(, E)20.6(v)8.2(g)-2.5(e)-2.5(n)6.1(iy)]TJ /Span<>> BDC ( )Tj EMC [(S)2.1(.)]TJ /Span<>> BDC ( )Tj EMC 12.101 0 Td [(S)15.8(u)6.1(r)2.4(o)-0.6(v)6.6(e)-3.5(g)-14.5(i)8.5(n)-6(, )]TJ 0 Tw -18.08 -1.218 Td [(A)3.6(l)4.8(ek)-17.5(s)4.9(e)-2.5(y)]TJ /Span<>> BDC ( )Tj EMC [(A)-12.5(.)]TJ /Span<>> BDC ( )Tj EMC [(P)25(on)1.9(om)4.3(ar)2.4(e)-2.6(n)7.5(k)12.9(o)-3.7(, O)-5.5(k)-17.5(s)7.8(a)-0.7(n)4.8(a)]TJ /Span<>> BDC ( )Tj EMC [(Y)33.7(u)7.7(. F)19.1(om)-1(e)-2.6(n)7.5(k)12.9(o)]TJ /T1_2 1 Tf 0.023 Tw 0 -2.436 TD (\255\026\036\031\036\025\034\224 \017\225 \032\026\020\017\022\032\221 \(\ ORCID\):)Tj /T1_0 1 Tf 0 Tw 0 -1.218 TD (\202\035\036\001\017\027 \212.\200.)Tj /Span<>> BDC ( )Tj EMC (\227 0000-0001-8863-2229)Tj T* (\202\004\022\026\f\024\r \221.\222.)Tj /Span<>> BDC ( )Tj EMC (\227 0000-0001-9294-5447)Tj T* (\234\026\b\n\026\021\024\r \212.\206.)Tj /Span<>> BDC ( )Tj EMC (\227 0000-0001-9780-7916)Tj T* (\205\024\n\036\027\022\024 \210.\236.)Tj /Span<>> BDC ( )Tj EMC (\227 0000-0001-9603-6988)Tj T* (\215\024\027\024\n\026\030\036\027\022\024 \202.\202.)Tj /Span<>> BDC ( )Tj EMC (\227 0000-0001-7203-1859)Tj 0 -1.218 TD (\222\020\027\026\021\036\027\022\024 \204.\202.)Tj /Span<>> BDC ( )Tj EMC (\227 0009-0005-1182-419X)Tj 23.244 14.614 Td (\221\031\030\024\r\036\020\017\027 \213.\221.)Tj /Span<>> BDC ( )Tj EMC (\227 0000-0001-5743-1344)Tj 0 -1.218 TD (\221\031\001\022\024\r \210.\222.)Tj /Span<>> BDC ( )Tj EMC (\227 0000-0001-9780-7916)Tj /T1_2 1 Tf 0.023 Tw 0 -2.436 TD (INFORMATION ABOUT THE AUTHORS \(ORCID\))Tj /T1_0 1 Tf 0 Tw 0 -1.218 TD (Denis V. Aleshin)Tj /Span<>> BDC ( )Tj EMC (\227 0000-0001-8863-2229)Tj T* [(Ser)-32(ge)-11(y I. A)-24.9(chk)-17(asov)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0001-9294-5447)Tj 0 -1.218 TD [(Dmi)-24(tr)-36.9(iy G. S)-16(hakhma)15.1(t)17(ov)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0001-9780-7916)Tj 0 -1.218 TD [(Ok)-10(sana Y)35(u. F)10.1(omenko)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0001-9603-6988)Tj T* [(Alek)-10(se)-10.9(y A. P)10(onomar)-23.9(enko)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0001-7203-1859)Tj T* [(Mar)-37(ia A. Igna)15.1(tenko)]TJ /Span<>> BDC ( )Tj EMC (\227 0009-0005-1182-419X)Tj T* [(Ev)-21(geniy S. Sur)-31.9(ovegin)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0001-5743-1344)Tj T* (Oleg I. Sushkov)Tj /Span<>> BDC ( )Tj EMC (\227 0000-0001-9780-7916)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 70.936 542.1599 Tm [(\r\031\024\034\033)48(\026)45(\024)-10(\223\033)48(\026)]TJ 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0 Tc -0.078 Tw 8 0 0 8 70.8661 529.3252 Tm (1.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(V)29(o)-16(gel)]TJ /Span<>> BDC ( )Tj EMC [(JD, F)10(eingold)]TJ /Span<>> BDC ( )Tj EMC [(DL, S)15(tew)-12(ar)-22(t)]TJ /Span<>> BDC ( )Tj EMC [(DB, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Cl)-31(inical P)35(r)-32.9(a)-17(c)-16(t)-32(ice Guidel)-31(ines )]TJ 0.093 Tw -1.296 -1.25 Td [(for Col)30.1(on V)29(ol)30(vul)35(us and A)-25(cute Col)30(onic P)35(seud)-16(o-Obstr)-22(uc)-15.9(t)-32(ion. )]TJ /T1_1 1 Tf (Dis Colon )Tj 0 Tw 0 -1.25 TD [(R)21(ectum.)]TJ /T1_0 1 Tf -0.04 Tw [( 2016;59\(7\):589\226600. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1097/DCR.0000000000000602)Tj 0 0 0 1 k /GS1 gs 0.088 Tw T* (2.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (Gingold)Tj /Span<>> BDC ( )Tj EMC 3.415 0 Td [(D, Mur)-23.9(r)-24(ell)]TJ /Span<>> BDC ( )Tj EMC [(Z. )0.5(Mana)-17(gement )0.5(of col)30(onic vol)30(vul)35.1(us. )]TJ /T1_1 1 Tf [(Clin )0.5(Colon )]TJ 0.023 Tw -4.711 -1.25 Td [(R)21(ectal Surg.)]TJ /T1_0 1 Tf [( 2012;25:236\226244. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1055/s-0032-1329535)Tj 0 0 0 1 k /GS1 gs 0.137 Tw T* (3.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Ba)-17(gar)-33(ani)]TJ /Span<>> BDC ( )Tj EMC (M, Conde)Tj /Span<>> BDC ( )Tj EMC [(A)35(S, L)35(ongo)]TJ /Span<>> BDC ( )Tj EMC [(R, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. S)-16(igmoid vol)30.1(vul)35(us in W)22(est )]TJ 0.006 Tw -1.296 -1.25 Td [(Afr)-37(ica: a p)25(r)-32(ospec)-16(t)-32(i)-16(ve stud)17(y on sur)-32(gical tr)-24(ea)15(tments. )]TJ /T1_1 1 Tf [(Dis Colon R)21(ectum)]TJ /T1_0 1 Tf 0 Tw (. )Tj 0.023 Tw T* [(1993;36:186\226190. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1007/BF02051177)Tj 0 0 0 1 k /GS1 gs 0.128 Tw T* (4.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(R)-10(aveent)-12.9(hir)-33(an)]TJ /Span<>> BDC ( )Tj EMC (V, Madiba)Tj /Span<>> BDC ( )Tj EMC [(TE, A)30(t)15(amanalp)]TJ /Span<>> BDC ( )Tj EMC [(S)16.9(S, e)-11.9(t)]TJ /Span<>> BDC ( )Tj EMC [(al. V)29(ol)30(vul)35(us of t)-13(he )]TJ 0.023 Tw -1.296 -1.25 Td [(sigmoid col)30.1(on. )]TJ /T1_1 1 Tf (Colorectal Dis)Tj /T1_0 1 Tf [(. 2010;12\(7 onl)-30.9(ine\): e1\226e17.)]TJ 0.34 Tw T* (5.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(S)-24(cha)-17(genv)-14.9(an L)35(eeuwen)]TJ /Span<>> BDC ( )Tj EMC [(JH. S)-16(igmoid vol)30(vul)35(us in a W)22(est Afr)-37(ica )]TJ 0.01 Tc -0.01 Tw -1.296 -1.25 Td [(popul)-16.1(a)15(t)-32(ion. )]TJ /T1_1 1 Tf 0.375 Tw 5.451 0 Td [(Dis Colon R)20.9(ectum.)]TJ /T1_0 1 Tf [(1985;28:712\226716. d)-16.1(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs -0.01 Tw (10.1007/)Tj 0 Tc 0 Tw -5.451 -1.25 Td (BF02560280)Tj 0 0 0 1 k /GS1 gs 0.103 Tw T* (6.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(L)35(opez-K)25(ostner)]TJ /Span<>> BDC ( )Tj EMC [(F, Ho)-16(ol)]TJ /Span<>> BDC ( )Tj EMC [(GR, L)-32(aver)-24(y)]TJ /Span<>> BDC ( )Tj EMC [(IC. Mana)-17(gement and causes of )]TJ 0.024 Tw -1.296 -1.25 Td [(a)-17(cute l)-16(ar)-32(ge-bo)-14(wel obstr)-22(uc)-16(t)-32(ion. )]TJ /T1_1 1 Tf (Surg Clin N Am.)Tj /T1_0 1 Tf ( 1997;77:1265\2261290. )Tj 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1016/S0039-6109\(05\)70617-4)Tj 0 0 0 1 k /GS1 gs 0.009 Tw -1.847 -1.25 Td (7.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Y)30(eo)]TJ /Span<>> BDC ( )Tj EMC [(HL, L)35(ee)]TJ /Span<>> BDC ( )Tj EMC [(S)-10(W. Col)30(or)-24(ec)-16(t)15(al emer)-31.9(genc)-24(ies: r)-23.9(ev)-16(iew and contr)-31.9(over)-10(sies )]TJ 0.079 Tw -1.296 -1.25 Td [(in t)-13(he mana)-17(gement of l)-16(ar)-32(ge bo)-14(wel obstr)-21.9(uc)-16(t)-32(ion. )]TJ /T1_1 1 Tf (J Gastrointest Surg)Tj /T1_0 1 Tf 0 Tw (. )Tj 0.023 Tw T* [(2013;17:2007\2262012. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1007/s11605-013-2343-x)Tj 0 0 0 1 k /GS1 gs -0.011 Tw T* (8.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Hal)-16(abi)]TJ /Span<>> BDC ( )Tj EMC [(W)31(J, Jaf)16(ar)-36.9(i)]TJ /Span<>> BDC ( )Tj EMC [(MD, K)-15.9(ang)]TJ /Span<>> BDC ( )Tj EMC [(CY, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Col)30(onic vol)30.1(vul)35(us in t)-13(he U)13(ni)-23.9(ted )]TJ 0.277 Tw -1.296 -1.25 Td [(S)15(t)15(a)15(tes: tr)-23.9(ends, outcomes, and p)25(r)-24(edic)-15.9(t)17(or)-10(s of mor)-22(t)15.1(al)-31(i)-24(t)-10(y. )]TJ /T1_1 1 Tf (Ann Surg.)Tj /T1_0 1 Tf 0 Tw ( )Tj 0.023 Tw T* [(2014;259:293\226301. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw [(10.1097/SL)-35(A.0b013e31828c88a)-16.9(c)]TJ 0 0 0 1 k /GS1 gs 0.07 Tw T* (9.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Ak)-16(inkuo)17.1(tu)]TJ /Span<>> BDC ( )Tj EMC (A, Samuel)Tj /Span<>> BDC ( )Tj EMC [(JC, Msisk)-17(a)]TJ /Span<>> BDC ( )Tj EMC [(N, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. T)47(he r)-32(ole of t)-13(he ana)15(t)17(omy )]TJ 0.067 Tw -1.296 -1.25 Td [(of t)-13(he sigmoid col)30(on in devel)30(oping sigmoid vol)30(vul)35(us: a case-contr)-31.9(ol )]TJ 0 Tw T* [(stud)17(y. )]TJ /T1_1 1 Tf 0.023 Tw 2.739 0 Td (Clin Anat.)Tj /T1_0 1 Tf [( 2011;24:634\226637. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1002/ca.21131)Tj 0 0 0 1 k /GS1 gs 0.006 Tc 0.35 Tw -2.739 -1.25 Td (10.)Tj /Span<>> BDC ( )Tj EMC 1.822 0 Td [(Br)-37.3(ian WC)19.6(A T)34.7(ian, V)-15.4(igut)-30.4(t)16.7(o)]TJ /Span<>> BDC ( )Tj EMC [(G, T)39.6(an)]TJ /Span<>> BDC ( )Tj EMC [(E, e)-12.4(t)]TJ /Span<>> BDC ( )Tj EMC [(al. WSES consensus)6( )]TJ 0 Tc 0.189 Tw -1.822 -1.25 Td [(guidel)-31(ines on sigmoid vol)30(vul)35(us mana)-17(gement. )]TJ /T1_1 1 Tf [(W)29(orld J Emerg Surg.)]TJ /T1_0 1 Tf 0 Tw ( )Tj 0.023 Tw T* [(2023;15;18\(1\):34. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1186/s13017-023-00502-x)Tj 0 0 0 1 k /GS1 gs 0.006 Tc 0.35 Tw T* (11.)Tj /Span<>> BDC ( )Tj EMC 1.82 0 Td (Swenson)Tj /Span<>> BDC ( )Tj EMC 4.117 0 Td [(BR, )0.5(K)20(w)-11.9(aan)]TJ /Span<>> BDC ( )Tj EMC 5.068 0 Td [(MR, )0.5(Bur)-24(k)-17(ar)-22(t)]TJ /Span<>> BDC ( )Tj EMC 5.635 0 Td [(NE, )0.6(e)-12(t)]TJ /Span<>> BDC ( )Tj EMC 3.295 0 Td [(al. )0.5(Col)30(onic )0.5(vol)30(vu)]TJ 0 Tc 0 Tw (-)Tj 0.008 Tc 0.35 Tw -19.935 -1.25 Td [(l)34.7(us: p)24.7(r)-24.2(esent)14.7(a)14.7(t)-32.3(ion and mana)-17.3(gement in me)-12.3(tr)-32.3(opol)-31.3(i)-24.3(t)14.7(an Minneso)16.7(t)14.7(a,)8( )]TJ 0 Tc 0.179 Tw T* [(U)13(ni)-24(ted S)15(t)15(a)15(tes. )]TJ /T1_1 1 Tf [(Dis Colon R)21(ectum. )]TJ /T1_0 1 Tf [(2012;55:444\226449. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1097/)Tj 29.055 37.5 Td (DCR.0b013e3182404b3d)Tj 0 0 0 1 k /GS1 gs 0.129 Tw T* (12.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(G)20(r)-32(oss)26(mann)]TJ /Span<>> BDC ( )Tj EMC [(EM, L)35(ongo)]TJ /Span<>> BDC ( )Tj EMC [(WE, S)15(tr)-32.9(a)15(t)-30(t)17(on)]TJ /Span<>> BDC ( )Tj EMC [(MD, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. S)-16(igmoid vol)30(vul)35.1(us )]TJ 0.022 Tw -1.796 -1.25 Td [(in Dep)32(ar)-22(tment of V)30(e)-12(ter)-33(ans Af)-56(f)16(air)-9.9(s Medical Center)-10(s. )]TJ /T1_1 1 Tf [(Dis Colon R)21(ectum. )]TJ /T1_0 1 Tf 0.023 Tw T* [(2000;43:414\226418. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1007/BF02258311)Tj 0 0 0 1 k /GS1 gs 0.001 Tw T* (13.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(T)40(an)]TJ /Span<>> BDC ( )Tj EMC (KK, Chong)Tj /Span<>> BDC ( )Tj EMC [(CS, S)-15.9(im)]TJ /Span<>> BDC ( )Tj EMC [(R. Mana)-17(gement of a)-17(cute sigmoid vol)30(vul)35(us: )]TJ -0.033 Tw -1.796 -1.25 Td [(an inst)-31.9(i)-24(tut)-32(ion\245s )0.5(e)-18(xper)-37(ience )0.5(over 9 year)-9.9(s. )]TJ /T1_1 1 Tf [(W)29(orld )0.5(J Surg. )]TJ /T1_0 1 Tf 0 Tw (2010;34:1943\226)Tj 0.023 Tw T* [(1948. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1007/s00268-010-0563-8)Tj 0 0 0 1 k /GS1 gs 0.014 Tw T* (14.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(L)-32(ar)-23.9(k)-16(in)]TJ /Span<>> BDC ( )Tj EMC 2.785 0 Td [(J)25(O, )0.5(T)47(hek)-16(iso)]TJ /Span<>> BDC ( )Tj EMC 4.691 0 Td [(TB, )0.5(W)12(aldr)-32(on)]TJ /Span<>> BDC ( )Tj EMC 4.965 0 Td [(R, )0.5(e)-12(t)]TJ /Span<>> BDC ( )Tj EMC 2.036 0 Td [(al. )0.5(R)13(ecur)-24(r)-23.9(ent )0.5(sigmoid )0.5(vol)30(vu)]TJ 0 Tw (-)Tj 0.061 Tw -16.273 -1.25 Td [(l)35(us-ear)-29.9(l)35(y r)-23.9(esec)-16(t)-32(ion ma)15(y obv)-16(ia)15(te l)-16(a)15(ter emer)-32(gency sur)-32(ger)-24(y and r)-24(educe )]TJ 0.201 Tw T* [(mor)-24(bidi)-23.9(t)-10(y and mor)-21.9(t)15(al)-31(i)-24(t)-10(y. )]TJ /T1_1 1 Tf [(Ann R Coll Surg Eng)13(l. )]TJ /T1_0 1 Tf 0 Tw (2009;91:205\226209. )Tj T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1308/003588409X391776)Tj 0 0 0 1 k /GS1 gs 0.26 Tw -1.847 -1.25 Td (15.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Mul)-16(as)]TJ /Span<>> BDC ( )Tj EMC [(C, Br)-22(una)]TJ /Span<>> BDC ( )Tj EMC [(M, Gar)-32(c)-23.9(ia-Ar)-16(mengol)]TJ /Span<>> BDC ( )Tj EMC [(J, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Mana)-17(gement of )]TJ 0.252 Tw -1.796 -1.25 Td [(col)30(onic )0.6(vol)30(vul)35(us. )0.6(E)35(xper)-37(ience )0.6(in )0.6(75 )0.5(p)32(a)15(t)-32(ients. )]TJ /T1_1 1 Tf 19.154 0 Td [(R)21(ev )0.6(Esp )0.5(Enfer)-14(m )0.6(Dig. )]TJ /T1_0 1 Tf 0.023 Tw -19.154 -1.25 Td [(2010;102:239\226248. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.4321/S1130-01082010000400004)Tj 0 0 0 1 k /GS1 gs 0.028 Tw T* (16.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Ak)-16(inkuo)17.1(tu)]TJ /Span<>> BDC ( )Tj EMC (A, Samuel)Tj /Span<>> BDC ( )Tj EMC [(JC, Msisk)-17(a)]TJ /Span<>> BDC ( )Tj EMC [(N, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. T)47(he r)-31.9(ole of t)-12.9(he ana)15(t)17(omy )]TJ 0.067 Tw -1.796 -1.25 Td [(of t)-13(he sigmoid col)30(on in devel)30(oping sigmoid vol)30(vul)35(us: a case-contr)-31.9(ol )]TJ 0 Tw T* [(stud)17(y. )]TJ /T1_1 1 Tf 0.023 Tw 2.739 0 Td (Clin Anat. )Tj /T1_0 1 Tf [(2011;24:634\226637. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1002/ca.21131)Tj 0 0 0 1 k /GS1 gs 0.01 Tw -2.739 -1.25 Td (17.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (\202\004\022\026\f\024\r)Tj /Span<>> BDC ( )Tj EMC (\221.\222. \202\027\024\n\026\035\017\017 \030\026\r\017\021\017\016 \017\ )Tj /Span<>> BDC ( )Tj EMC (\023\024\035\024\032\036\027\017\016 \021\024\035\f\021\024\005 \022\017\ \001\022\017. )Tj -0.031 Tw -1.796 -1.25 Td (\025\035\017\027\017\022\026, \007\017\026\020\027\024\f\021\017\022\026\ , \035\036\004\036\027\017\036. \212\017\f\f. \007-\030\026 \n\036\007. \ \027\026\031\022, \204\024\f\022\r\026, 2003, )Tj 0.023 Tw T* (\f.)Tj /Span<>> BDC ( )Tj EMC (294.)Tj 0.112 Tw T* (18.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (\202\035\036\001\017\027)Tj /Span<>> BDC ( )Tj EMC (\212.\200., \202\004\022\026\f\024\r)Tj /Span<>> BDC ( )Tj EMC (\221.\222., \234\026\b\n\026\021\024\r)Tj /Span<>> BDC ( )Tj EMC (\212.\206., \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. \025\026\004\036\f\021\r\024 )Tj 0.321 Tw -1.796 -1.25 Td [(\032\017\027\017 )0.5(\002\024\035\034\027\t\b )0.6(\017\007\017\024\023\026\021\017\004\036\f\022\017\n )0.5(\n\036\020\026\022\024\035\024\027 )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC [(\036\020\024 )0.5(\r\026\017\n\024\f\r\016\034 )]TJ 0.269 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\022\035\017\027\017\004\036\f\022\024\005 \f\017\n\023\021\024\n\026\021\ \017\022\024\005 \017)Tj /Span<>> BDC ( )Tj EMC (\030\036\031\035\034\021\026\021\026\n\017 \007\017\026\020\027\024\f\021\ \017\004\036\f\022\017\b )Tj 0 Tw T* (\021\036\f\021\024\r. )Tj /T1_1 1 Tf 3.204 0 Td (\222\n\023\n\033\032\n\013\024\n\023\n\202\025\002.)Tj /T1_0 1 Tf 0.037 Tw [( 2023;2\(84\):40\22648. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.33878/2073-)Tj -3.204 -1.25 Td (7556-2023-22-2-40-48)Tj 0 0 0 1 k /GS1 gs 0.17 Tw T* (19.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(P)30(er)-24(r)-31.9(o)17(t)]TJ /Span<>> BDC ( )Tj EMC [(L, F)10(ohlen)]TJ /Span<>> BDC ( )Tj EMC [(A, Al)30(ves)]TJ /Span<>> BDC ( )Tj EMC [(A, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Mana)-16.9(gement of t)-12.9(he col)30(onic )]TJ 0.041 Tw -1.796 -1.25 Td [(vol)30(vul)35.1(us in 2016. )]TJ /T1_1 1 Tf (J Visc Surg. )Tj /T1_0 1 Tf [(2016;153\(3\):183\226192. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1016/j.)Tj T* [(jv)-16(iscsur)-31.9(g.2016.03.006)]TJ 0 0 0 1 k /GS1 gs 0.013 Tw T* (20.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Madiba)Tj /Span<>> BDC ( )Tj EMC 3.118 0 Td [(TE, )0.5(Haf)-56(f)16(ajee)]TJ /Span<>> BDC ( )Tj EMC [(MR. )0.5(S)-16(igmoid )0.5(col)30(on mor)-24(phol)30.1(o)-16(g)16(y in )0.5(t)-13(he popu)]TJ 0 Tw (-)Tj 0.048 Tw -4.914 -1.25 Td [(l)-16(a)15(t)-32(ion gr)-32(oups of Dur)-23.9(ban, S)-15.9(out)-13(h Afr)-37(ica, wi)-24(t)-12.9(h spec)-24(ial r)-24(efer)-24(ence t)17.1(o sig)]TJ 0 Tw (-)Tj 0.023 Tw T* [(moid vol)30.1(vul)35(us. )]TJ /T1_1 1 Tf (Clin Anat. )Tj /T1_0 1 Tf [(2011;24:441\226453. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1002/ca.21100)Tj /T1_3 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 70.936 201.1759 Tm (REFERENCES)Tj 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0 Tc -0.078 Tw 8 0 0 8 70.8661 188.3412 Tm (1.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(V)29(o)-16(gel)]TJ /Span<>> BDC ( )Tj EMC [(JD, F)10(eingold)]TJ /Span<>> BDC ( )Tj EMC [(DL, S)15(tew)-12(ar)-22(t)]TJ /Span<>> BDC ( )Tj EMC [(DB, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Cl)-31(inical P)35(r)-32.9(a)-17(c)-16(t)-32(ice Guidel)-31(ines )]TJ 0.093 Tw -1.296 -1.25 Td [(for Col)30.1(on V)29(ol)30(vul)35(us and A)-25(cute Col)30(onic P)35(seud)-16(o-Obstr)-22(uc)-15.9(t)-32(ion. )]TJ /T1_1 1 Tf (Dis Colon )Tj 0 Tw T* [(R)21(ectum.)]TJ /T1_0 1 Tf -0.04 Tw [( 2016;59\(7\):589\226600. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1097/DCR.0000000000000602)Tj 0 0 0 1 k /GS1 gs 0.088 Tw T* (2.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (Gingold)Tj /Span<>> BDC ( )Tj EMC 3.415 0 Td [(D, Mur)-23.9(r)-24(ell)]TJ /Span<>> BDC ( )Tj EMC [(Z. )0.5(Mana)-17(gement )0.5(of col)30(onic vol)30(vul)35.1(us. )]TJ /T1_1 1 Tf [(Clin )0.5(Colon )]TJ 0.023 Tw -4.711 -1.25 Td [(R)21(ectal Surg.)]TJ /T1_0 1 Tf [( 2012;25:236\226244. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1055/s-0032-1329535)Tj 0 0 0 1 k /GS1 gs 0.137 Tw T* (3.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Ba)-17(gar)-33(ani)]TJ /Span<>> BDC ( )Tj EMC (M, Conde)Tj /Span<>> BDC ( )Tj EMC [(A)35(S, L)35(ongo)]TJ /Span<>> BDC ( )Tj EMC [(R, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. S)-16(igmoid vol)30.1(vul)35(us in W)22(est )]TJ 0.006 Tw -1.296 -1.25 Td [(Afr)-37(ica: a p)25(r)-32(ospec)-16(t)-32(i)-16(ve stud)17(y on sur)-32(gical tr)-24(ea)15(tments. )]TJ /T1_1 1 Tf [(Dis Colon R)21(ectum)]TJ /T1_0 1 Tf 0 Tw (. )Tj 0.023 Tw T* [(1993;36:186\226190. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1007/BF02051177)Tj 0 0 0 1 k /GS1 gs 0.128 Tw T* (4.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(R)-10(aveent)-12.9(hir)-33(an)]TJ /Span<>> BDC ( )Tj EMC (V, Madiba)Tj /Span<>> BDC ( )Tj EMC [(TE, A)30(t)15(amanalp)]TJ /Span<>> BDC ( )Tj EMC [(S)16.9(S, e)-11.9(t)]TJ /Span<>> BDC ( )Tj EMC [(al. V)29(ol)30(vul)35(us of t)-13(he )]TJ 0.023 Tw -1.296 -1.25 Td [(sigmoid col)30.1(on. )]TJ /T1_1 1 Tf (Colorectal Dis)Tj /T1_0 1 Tf [(. 2010;12\(7 onl)-30.9(ine\): e1\226e17.)]TJ 0.34 Tw T* (5.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(S)-24(cha)-17(genv)-14.9(an L)35(eeuwen)]TJ /Span<>> BDC ( )Tj EMC [(JH. S)-16(igmoid vol)30(vul)35(us in a W)22(est Afr)-37(ica )]TJ 0.01 Tc -0.01 Tw 27.759 12.5 Td [(popul)-16.1(a)15(t)-32(ion. )]TJ /T1_1 1 Tf 0.375 Tw 5.451 0 Td [(Dis Colon R)20.9(ectum.)]TJ /T1_0 1 Tf [(1985;28:712\226716. d)-16.1(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs -0.01 Tw (10.1007/)Tj 0 Tc 0 Tw -5.451 -1.25 Td (BF02560280)Tj 0 0 0 1 k /GS1 gs 0.103 Tw T* (6.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(L)35(opez-K)25(ostner)]TJ /Span<>> BDC ( )Tj EMC [(F, Ho)-16(ol)]TJ /Span<>> BDC ( )Tj EMC [(GR, L)-32(aver)-24(y)]TJ /Span<>> BDC ( )Tj EMC [(IC. Mana)-17(gement and causes of )]TJ 0.024 Tw -1.296 -1.25 Td [(a)-17(cute l)-16(ar)-32(ge-bo)-14(wel obstr)-22(uc)-16(t)-32(ion. )]TJ /T1_1 1 Tf (Surg Clin N Am.)Tj /T1_0 1 Tf ( 1997;77:1265\2261290. )Tj 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1016/S0039-6109\(05\)70617-4)Tj 0 0 0 1 k /GS1 gs 0.009 Tw -1.847 -1.25 Td (7.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Y)30(eo)]TJ /Span<>> BDC ( )Tj EMC [(HL, L)35.1(ee)]TJ /Span<>> BDC ( )Tj EMC [(S)-10(W. Col)30(or)-24(ec)-16(t)15(al emer)-31.9(genc)-24(ies: r)-24(ev)-16(iew and contr)-31.9(over)-10(sies )]TJ 0.079 Tw -1.296 -1.25 Td [(in t)-13(he mana)-17.1(gement of l)-16(ar)-32(ge bo)-14(wel obstr)-21.9(uc)-16(t)-32(ion. )]TJ /T1_1 1 Tf (J Gastrointest Surg)Tj /T1_0 1 Tf 0 Tw (. )Tj 0.023 Tw T* [(2013;17:2007\2262012. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1007/s11605-013-2343-x)Tj 0 0 0 1 k /GS1 gs -0.011 Tw T* (8.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Hal)-16(abi)]TJ /Span<>> BDC ( )Tj EMC [(W)31(J, Jaf)16(ar)-36.9(i)]TJ /Span<>> BDC ( )Tj EMC [(MD, K)-16(ang)]TJ /Span<>> BDC ( )Tj EMC [(CY, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Col)30(onic vol)30.1(vul)35(us in t)-13(he U)12.9(ni)-23.9(ted )]TJ 0.277 Tw -1.296 -1.25 Td [(S)15(t)15(a)15(tes: tr)-23.9(ends, outcomes, and p)25(r)-24(edic)-15.9(t)17(or)-10(s of mor)-22(t)15.1(al)-31(i)-24(t)-10(y. )]TJ /T1_1 1 Tf (Ann Surg.)Tj /T1_0 1 Tf 0 Tw ( )Tj 0.023 Tw T* [(2014;259:293\226301. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw [(10.1097/SL)-35(A.0b013e31828c88a)-16.9(c)]TJ /T1_4 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\033\030\031\030\213\b)-20.9(\035\231\213\233\t \021\032)50(\b)42(\032\231\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj -51.938 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 23, \023\0221)69(, 202)69(4)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 23, \023\0221)69(, 202)69(4)]TJ /T1_5 1 Tf 25 0 0 25 28.1902 56.0378 Tm (40)Tj ET endstream endobj 2228 0 obj <>/Border[0 0 0]/H/N/Rect[183.289 516.621 291.968 507.165]/Subtype/Link/Type/Annot>> endobj 2229 0 obj <>/Border[0 0 0]/H/N/Rect[187.042 496.621 269.698 487.165]/Subtype/Link/Type/Annot>> endobj 2230 0 obj <>/Border[0 0 0]/H/N/Rect[147.366 466.621 217.054 457.325]/Subtype/Link/Type/Annot>> endobj 2231 0 obj <>/Border[0 0 0]/H/N/Rect[261.495 426.621 291.968 417.165]/Subtype/Link/Type/Annot>> endobj 2232 0 obj <>/Border[0 0 0]/H/N/Rect[70.8661 416.621 110.642 407.325]/Subtype/Link/Type/Annot>> endobj 2233 0 obj <>/Border[0 0 0]/H/N/Rect[85.6442 386.621 194.812 377.325]/Subtype/Link/Type/Annot>> endobj 2234 0 obj <>/Border[0 0 0]/H/N/Rect[155.366 356.621 248.39 347.325]/Subtype/Link/Type/Annot>> endobj 2235 0 obj <>/Border[0 0 0]/H/N/Rect[151.366 326.621 258.182 317.325]/Subtype/Link/Type/Annot>> endobj 2236 0 obj <>/Border[0 0 0]/H/N/Rect[202.156 296.621 261.636 287.165]/Subtype/Link/Type/Annot>> endobj 2237 0 obj <>/Border[0 0 0]/H/N/Rect[147.326 266.621 244.35 257.325]/Subtype/Link/Type/Annot>> endobj 2238 0 obj <>/Border[0 0 0]/H/N/Rect[262.057 236.621 291.968 227.165]/Subtype/Link/Type/Annot>> endobj 2239 0 obj <>/Border[0 0 0]/H/N/Rect[303.307 536.621 381.811 527.325]/Subtype/Link/Type/Annot>> endobj 2240 0 obj <>/Border[0 0 0]/H/N/Rect[379.807 506.621 449.495 497.325]/Subtype/Link/Type/Annot>> endobj 2241 0 obj <>/Border[0 0 0]/H/N/Rect[338.503 476.621 431.975 467.325]/Subtype/Link/Type/Annot>> endobj 2242 0 obj <>/Border[0 0 0]/H/N/Rect[318.085 436.621 411.845 427.325]/Subtype/Link/Type/Annot>> endobj 2243 0 obj <>/Border[0 0 0]/H/N/Rect[383.807 406.621 504.239 397.325]/Subtype/Link/Type/Annot>> endobj 2244 0 obj <>/Border[0 0 0]/H/N/Rect[434.597 376.621 494.077 367.165]/Subtype/Link/Type/Annot>> endobj 2245 0 obj <>/Border[0 0 0]/H/N/Rect[471.682 306.621 524.409 297.165]/Subtype/Link/Type/Annot>> endobj 2246 0 obj <>/Border[0 0 0]/H/N/Rect[303.307 296.621 377.387 287.325]/Subtype/Link/Type/Annot>> endobj 2247 0 obj <>/Border[0 0 0]/H/N/Rect[489.898 276.621 524.409 267.165]/Subtype/Link/Type/Annot>> endobj 2248 0 obj <>/Border[0 0 0]/H/N/Rect[303.307 266.621 375.194 257.325]/Subtype/Link/Type/Annot>> endobj 2249 0 obj <>/Border[0 0 0]/H/N/Rect[461.279 236.621 520.759 227.165]/Subtype/Link/Type/Annot>> endobj 2250 0 obj <>/Border[0 0 0]/H/N/Rect[183.289 175.637 291.968 166.181]/Subtype/Link/Type/Annot>> endobj 2251 0 obj <>/Border[0 0 0]/H/N/Rect[187.042 155.637 269.698 146.181]/Subtype/Link/Type/Annot>> endobj 2252 0 obj <>/Border[0 0 0]/H/N/Rect[147.366 125.637 217.054 116.341]/Subtype/Link/Type/Annot>> endobj 2253 0 obj <>/Border[0 0 0]/H/N/Rect[493.936 195.637 524.409 186.181]/Subtype/Link/Type/Annot>> endobj 2254 0 obj <>/Border[0 0 0]/H/N/Rect[303.307 185.637 343.083 176.341]/Subtype/Link/Type/Annot>> endobj 2255 0 obj <>/Border[0 0 0]/H/N/Rect[318.085 155.637 427.253 146.341]/Subtype/Link/Type/Annot>> endobj 2256 0 obj <>/Border[0 0 0]/H/N/Rect[387.807 125.637 480.831 116.341]/Subtype/Link/Type/Annot>> endobj 2257 0 obj <>/Border[0 0 0]/H/N/Rect[383.807 95.6373 490.623 86.3412]/Subtype/Link/Type/Annot>> endobj 2287 0 obj <> endobj 2286 0 obj <> endobj 2285 0 obj <> endobj 2284 0 obj <> endobj 2283 0 obj <> endobj 2282 0 obj <> endobj 2281 0 obj <> endobj 2280 0 obj <> endobj 2279 0 obj <> endobj 2278 0 obj <> endobj 2277 0 obj <> endobj 2276 0 obj <> endobj 2275 0 obj <> endobj 2274 0 obj <> endobj 2273 0 obj <> endobj 2272 0 obj <> endobj 2271 0 obj <> endobj 2270 0 obj <> endobj 2269 0 obj <> endobj 2268 0 obj <> endobj 2267 0 obj <> endobj 2266 0 obj <> endobj 2265 0 obj <> endobj 2264 0 obj <> endobj 2263 0 obj <> endobj 2262 0 obj <> endobj 2261 0 obj <> endobj 2260 0 obj <> endobj 2259 0 obj <> endobj 2258 0 obj <> endobj 2225 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\210\013\n)-10(\026)11(\025\002\020 \002\220\006\n\013 \222\013\r\025\002\025\026)11(\013 \006\220\202)10(\024\025\r\220\201\001\025\203 \n\220\n\220 \215\022\221\013\227\220\016\ \001\026)11(\025\r )]TJ 0 -1 TD [(\006\022\220\201\220\025\221\013\026\220\017\016\006\n\220\024 \024\016\202\ )10.1(\013\n)10(\025\007\025\001/\024\016\202)10(\013\002\016\n)-9.9(\026)-20(\215\024)]TJ 33.279 1 Td [(Risk factor)20(s of sigmoid v)10(olv)10(ulus in patients with idiopathic megacolon)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf -0.038 Tw 10 0 0 10 42.5197 724.8299 Tm (\235\031\027\022\006\017\017 \023\030\016\n\024\005 \022\017\001\022\017\ , \f\021\026\021\017\f\021\017\004\036\f\022\017 \027\026\004\017\n\t\b\ \030\026)Tj 0 Tw (-)Tj 0.056 Tw 0 -1.218 TD (\035\017\004\017\005 \n\036\032\007\031 \023\026\006\017\036\027\021\026\ \n\017 \f)Tj /Span<>> BDC ( )Tj EMC (\026\r\024\030\024\021\024\n \017)Tj /Span<>> BDC ( )Tj EMC (\002\036, \027\026\n \024\002)Tj 0 Tw (-)Tj 0.149 Tw T* (\027\026\030\031\032\017\021\034 \027\036 \031\007\026\035\024\f\034. \213\ \007\017\027\f\021\r\036\027\027\024\036 \017\f\022\035\033\004\036\027\017\ \036)Tj /Span<>> BDC ( )Tj EMC (\227 )Tj 0.172 Tw T* (\004\026\f\021\024\021\026 \007\017\f\021\026\035\034\027\024\005 \026\007\ \036\030\032\022\017 \022\024\027\021\030\026\f\021\026 \023\024)Tj /Span<>> BDC ( )Tj EMC (\007\026\027\027\t\n )Tj 0.175 Tw T* (\023\026\f\f\026\032\026 \002\026\030\017\036\r\024\005 \r\r\036\f\017 \ \023\024)Tj /Span<>> BDC ( )Tj EMC (\240\025\230, \022\024\021\024\030\026\016 \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017)Tj 0 Tw (-)Tj 0.065 Tw T* (\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\026\r\024\030\024\021\024\n \002\t\035\026 \007\024\f\021\024\r\036\030\ \027\024 \n\036\027\034\001\036. \203\026\030\016\007\031 )Tj -0.044 Tw 0 -1.218 TD (\f)Tj /Span<>> BDC ( )Tj EMC (\n\036\027\034\001\036\005 \004\026\f\021\024\021\024\005 \032\026\035\024\ \002 \027\026)Tj /Span<>> BDC ( )Tj EMC (\022\026\035\024\n\026\026\027\017\036 \017)Tj /Span<>> BDC ( )Tj EMC (\n\036\027\034\001\036\005 )Tj 0.028 Tw 0 -1.218 TD (\r\t\030\026\032\036\027\027\024\f\021\034\033 \f\017\n\023\021\024\n\024\ \r \030\026\f\f\021\030\024\005\f\021\r\026 \007\036\235\036\022\026\006\ \017\017, )Tj 0.248 Tw T* (\220\021\024 \024\021\030\026\032\026\036\021 \n\036\027\034\001\017\005\ \030\017\f\022 \026\r\024\030\024\021\026 \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r )Tj -0.031 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\017\007\017\024\023\026\021\017\004\036\f\022\017\n \n\036\020\026\030\036\ \022\021\031\n \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\020\035\026\f\031\036\021\f\016 \f)Tj /Span<>> BDC ( )Tj EMC (\030\036\031\035\034)Tj 0 Tw (-)Tj T* (\021\026\021\026\n\017 \017\030\030\017\020\024\f\022\024\023\017\017.)Tj 0.069 Tw T* (\204\t \027\026\n\036\030\036\027\027\024 \027\036 \r\022\035\033\004\026\ \035\017 \r)Tj /Span<>> BDC ( )Tj EMC (\026\027\026\035\017 \021\026\022\024\005 \023\030\017\027\026\022, )Tj 0.067 Tw 0 -1.218 TD (\022\026\022 \001\017\030\017\027\026 \024\f\027\024\r\026\027\017\016 \002\ \030\t\032\036\005\022\017 \f\017\020\n\024\r\017\007\027\024\005 \022\017\ \001)Tj 0 Tw (-)Tj 0.245 Tw 0 -1.218 TD (\022\017, \021\026\022 \022\026\022 \036\020\024 \024\004\036\027\034 \f\ \035\024\032\027\024 \024\006\036\027\017\021\034 \f)Tj /Span<>> BDC ( )Tj EMC (\023\024\n\024\013\034\033 )Tj 0.056 Tw 0 -1.218 TD [(\007\017\026\020\027\024\f\021\017\004\036\f\022\017\b )0.5(\021\036\f\021\024\r, )0.5(\026)]TJ /Span<>> BDC ( )Tj EMC [(\027\026\001\036\005 \006\036\035\034\033 )0.5(\002\t\035\026 \023\024\023\t\021)]TJ 0 Tw (-)Tj 0.102 Tw T* (\022\026 \024\023\030\036\007\036\035\017\021\034 \235\026\022\021\024\030\ \t \030\017\f\022\026 \026\r\024\030\024\021\026 \027\026)Tj /Span<>> BDC ( )Tj EMC (\007\024\024\023\036\030\026)Tj 0 Tw (-)Tj T* (\006\017\024\027\027\024\n \220\021\026\023\036.)Tj 0.197 Tw T* (\221\024\020\035\026\f\027\024 \n\027\024\020\024\235\026\022\021\024\030\ \027\024\n\031 \035\024\020\017\f\021\017\004\036\f\022\024\n\031 \030\036\ \020\030\036\f)Tj 0 Tw (-)Tj 0.593 Tw T* [(\f\017\024\027\027\024\n\031 )0.6(\026\027\026\035\017\031, )0.5(\027\036\026\r\017\f\017\n\t\n\017 )0.5(\023\030\036\007\017\022\021\024\030\026\n\017, )]TJ 0.095 Tw T* (\f\021\026\021\017\f\021\017\004\036\f\022\017 \027\026\004\017\n\024 \026\ \f\f\024\006\017\017\030\024\r\026\027\027\t\n\017 \f)Tj /Span<>> BDC ( )Tj EMC (\030\017\f\022\024\n )Tj 0.223 Tw T* [(\026\r\024\030\024\021\026, )0.6(\016\r\035\016\035\017\f\034 )0.5(\001\017\030\017\027\026 )0.6(\f\017\020\n\024\r\017\007\027\024\005 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 19.046 0 Td (\023\030\016\n\024\005 )Tj 0.153 Tw -19.046 -1.218 Td (\022\017\001\024\022. \215\030\017)Tj /Span<>> BDC ( )Tj EMC 5.298 0 Td [(\220\021\024\n )0.5(\027\026\017\035\031\004\001\017\036 \b\026\030\026\022\021\036\030\017\f\ \021\017\022\017, )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC 15.11 0 Td (\021\024\004)Tj 0 Tw (-)Tj 0.164 Tw -20.408 -1.218 Td (\022\017 \030\036\027\017\016 \f\021\026\021\017\f\021\017\004\036\f\022\ \024\005 \027\026\004\017\n\024\f\021\017 \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\020\027\024\f\021\017)Tj 0 Tw (-)Tj 0.112 Tw T* (\004\036\f\022\024\005 \f\023\024\f\024\002\027\024\f\021\017, \024\022\026\ \026\035\017\f\034 \031)Tj /Span<>> BDC ( )Tj EMC (\n\024\007\036\035\017, \r)Tj /Span<>> BDC ( )Tj EMC (\022\024\021\024\030\031\033 )Tj 0.228 Tw T* (\002\t\035\017 \r\022\035\033\004\036\027\t \021\024\035\034\022\024 \030\ \026\n\036\030\t \022\017\001\024\022 \023\024)Tj /Span<>> BDC ( )Tj EMC (\007\026\027\027\t\n )Tj 0.049 Tw T* (\017\030\030\017\020\024\f\022\024\023\017\017)Tj /Span<>> BDC ( )Tj EMC (\227 \007\035\017\027\026 \017)Tj /Span<>> BDC ( )Tj EMC (\001\017\030\017\027\026 \f\017\020\n\024\r\017\007\027\024\005 \022\017\ \001)Tj 0 Tw (-)Tj 0.307 Tw T* (\022\017 \017)Tj /Span<>> BDC ( )Tj EMC (\001\017\030\017\027\026 \023\030\016\n\024\005 \022\017\001\022\017. \211\ \007\026\035\036\027\017\036 \023\026\030\026\n\036\021\030\026 )Tj 0.123 Tw T* (\007\035\017\027\t \f\017\020\n\024\r\017\007\027\024\005 \022\017\001\022\ \017 \017\035\017 \032\036 \007\024\002\026\r\035\036\027\017\036 \022\035\ \017)Tj 0 Tw (-)Tj 0.213 Tw T* (\027\017\004\036\f\022\017\b \017)Tj /Span<>> BDC ( )Tj EMC (\017\027\t\b \007\017\026\020\027\024\f\021\017\004\036\f\022\017\b \023\ \030\017\027\026\022\024\r \035\017\001\034 )Tj 0.127 Tw T* (\031\b\031\007\001\026\035\024 \022\026\004\036\f\021\r\036\027\027\t\036\ \b\026\030\026\022\021\036\030\017\f\021\017\022\017. \202)Tj /Span<>> BDC ( )Tj EMC (\007\035\016 \220\021\024\005 )Tj 0.189 Tw T* (\n\024\007\036\035\017 \023\024)Tj /Span<>> BDC ( )Tj EMC (\007\026\027\027\t\n ROC-\026\027\026\035\017\026 \023\024\035\031\004\036\ \027\t \b\024\030\024\001\017\036 )Tj 0.269 Tw T* (\023\026\030\026\n\036\021\030\t)Tj /Span<>> BDC ( )Tj EMC (\227 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\r\t\f\024\022\024\005 \f\021\026\021\017\f\021\017\004\036\f\022\024\005\ \027\026\004\017)Tj 0 Tw (-)Tj 0.262 Tw T* (\n\024\f\021\017 \023\035\024\013\026\007\034 \023\024\007 \022\030\017\r\ \024\005 \f\024\f\021\026\r\017\035\026 0,93, \026)Tj /Span<>> BDC ( )Tj EMC (\004\031\r)Tj 0 Tw (-)Tj 0.235 Tw T* (\f\021\r\017\021\036\035\034\027\024\f\021\034 \017)Tj /Span<>> BDC ( )Tj EMC (\f\023\036\006\017\235\017\004\027\024\f\021\034)Tj /Span<>> BDC ( )Tj EMC (\227 82,4% \017 89,5%, )Tj 0 Tw T* (\f\024\024\021\r\036\021\f\021\r\036\027\027\024.)Tj 0.249 Tw T* (\215\024\220\021\024\n\031 \023\024)Tj /Span<>> BDC ( )Tj EMC 5.405 0 Td [(\007\026\027\027\024\005 )0.5(\n\024\007\036\035\017 \002\t\035\026 )0.5(\023\024\f\021\030\024\036\027\026 \027\024\n\024)]TJ 0 Tw (-)Tj 0.161 Tw -5.405 -1.218 Td (\020\030\026\n\n\026 \023\030\024\020\027\024\017\030\024\r\026\027\017\ \016 \030\017\f\022\026 \026\r\024\030\024\021\026 \f\017\020\n\024\r\017\ \007)Tj 0 Tw (-)Tj -0.038 Tw T* (\027\024\005 \022\017\001\022\017 \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\017\007\017\024\023\026\021\017\004\036\f\022\017\n \n\036\020\026\022\024\ \035\024\027/)Tj 0.121 Tw T* [(\n\036\020\026\030\036\022\021\031\n )0.5(\023\024)]TJ /Span<>> BDC ( )Tj EMC [(\030\026\n\036\030\026\n )0.5(\023\030\016\n\024\005 \017)]TJ /Span<>> BDC ( )Tj EMC 15.014 0 Td [(\f\017\020\n\024\r\017\007\027\024\005 )0.5(\022\017)]TJ 0 Tw (-)Tj -15.014 -1.218 Td (\001\024\022 \(\217\017\f.)Tj /Span<>> BDC ( )Tj EMC (2\).)Tj 0.318 Tw T* [(\203\026\017\002\024\035\036\036 )0.6(\024\002\013\017\036 )0.5(\r\t\r\024\007\t, )0.5(\022\024\021\024\030\t\036 )0.5(\n\024\032\027\024 )0.6(\f\007\036\035\026\021\034 )]TJ 0.243 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC (\024\f\027\024\r\026\027\017\017 \027\024\n\024\020\030\026\n\n\t, \f\035\ \036\007\031\033\013\017\036: \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\f\031\n\n\036 )Tj -0.022 Tw T* (\002\026\035\035\024\r \002\024\035\036\036 144 \030\017\f\022 \026\r\024\ \030\024\021\026 \002\024\035\036\036 90%. \215\030\017)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\n )Tj 0.111 Tw T* [(\027\024\030\n\026\035\034\027\t\036 )0.6(\030\026\n\036\030\t )0.5(\023\030\016\n\024\005 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 13.56 0 Td [(\f\017\020\n\024\r\017\007\027\024\005 )0.6(\022\017\001\024\022, )]TJ 0.169 Tw -13.56 -1.218 Td [(\021\024 )0.5(\036\f\021\034 )0.6(\023\030\016\n\026\016 )0.5(\022\017\001\022\026 )0.6(\027\036 )0.5(\002\024\035\036\036 )0.5(8,5 )0.5(\f\n )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC 17.875 0 Td (\f\017\020\n\024\r\017\007)Tj 0 Tw (-)Tj 0.058 Tw -17.875 -1.218 Td (\027\026\016)Tj /Span<>> BDC ( )Tj EMC (\227 \027\036 \001\017\030\036 6 \f\n, \f\r\016\026\027\t \f)Tj /Span<>> BDC ( )Tj EMC (\030\017\f\022\024\n \026\r\024\030\024\021\026 \n\036)Tj 0 Tw (-)Tj 0.081 Tw T* (\027\036\036, \004\036\n \r)Tj /Span<>> BDC ( )Tj EMC (10% \027\026\002\035\033\007\036\027\017\005. \213\f\035\017 \n\036\020\026\ \030\036\022\021\031\n \024\021\f\031\021)Tj 0 Tw (-)Tj 0.124 Tw T* (\f\021\r\031\036\021, \027\024 \001\017\030\017\027\026 \f\017\020\n\024\ \r\017\007\027\024\005 \022\017\001\022\017 \002\024\035\036\036 12)Tj /Span<>> BDC ( )Tj EMC (\f\n, )Tj 0.24 Tw T* (\021\024 \r\036\030\024\016\021\027\024\f\021\034 \026\r\024\030\024\021\ \026 \023\030\036\r\t\001\026\036\021 90%. \200)Tj /Span<>> BDC ( )Tj EMC (\021\024 \032\036 )Tj 0.055 Tw T* (\r\030\036\n\016 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\027\026\004\017\021\036\035\034\027\024\n \n\036\020\026\030\036\022\021\ \031\n, \022\024\020\007\026 \023\024\023\036\030\036\004)Tj 0 Tw (-)Tj -0.032 Tw T* (\027\t\005 \030\026\n\036\030 \023\030\016\n\024\005 \022\017\001\022\017\ \002\024\035\036\036 11 \f\n, \030\017\f\022 \026\r\024\030\024\021\026\ )Tj 0.081 Tw T* (\n\036\027\036\036 90% \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\035\033\002\024\n \030\026\n\036\030\036 \f\017\020\n\024\r\017\007\027\ \024\005 \022\017\001\022\017. )Tj 0.134 Tw T* [(\203\026\022\024\027\036\006, )0.6(\022\024\020\007\026 )0.5(\001\017\030\017\027\026 )0.5(\023\030\016\n\024\005 )0.6(\022\017\001\022\017 )0.5(\n\036\027\036\036 )0.6(11 )0.5(\f\n, )]TJ 0.015 Tw T* (\026)Tj /Span<>> BDC ( )Tj EMC (\f\017\020\n\024\r\017\007\027\024\005)Tj /Span<>> BDC ( )Tj EMC (\227 \002\024\035\036\036 9,7 \f\n, \r\024\n\024\032\027\t \030\026\035\ \017\004\027\t\036 )Tj 0.156 Tw 23.244 64.543 Td (\f\024\004\036\021\026\027\017\016 \f)Tj /Span<>> BDC ( )Tj EMC (\r\036\030\024\016\021\027\024\f\021\034\033 \026\r\024\030\024\021\026\ \002\024\035\036\036 90%, \022\024)Tj 0 Tw (-)Tj 0.093 Tw T* (\021\024\030\t\036 \n\024\032\027\024 \030\026\f\f\n\026\021\030\017\r\026\ \021\034 \022\026\022 \023\024\022\026\026\027\017\036 \022)Tj /Span<>> BDC ( )Tj EMC (\b\017\030\031\030)Tj 0 Tw (-)Tj 0.274 Tw T* (\020\017\004\036\f\022\024\n\031 \r\n\036\001\026\021\036\035\034\f\021\r\ \031 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\024\021\f\031\021\f\021\r\017\017 \026\r\024\030\024\021\026 )Tj 0 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\026\027\026\n\027\036\036.)Tj 0.344 Tw T* (\203\036\007\024\f\021\026\021\022\024\n \023\030\036\007\035\024\032\036\ \027\027\024\005 \027\024\n\024\020\030\026\n\n\t \016\r\035\016\036\021\ \f\016, )Tj 0.042 Tw T* (\036\f\021\036\f\021\r\036\027\027\024, \036\036 \023\024\f\021\030\024\036\ \027\017\036 \027\026)Tj /Span<>> BDC ( )Tj EMC (\024\f\027\024\r\036 \030\036\021\030\024\f\023\036\022\021\017\r)Tj 0 Tw (-)Tj 0.242 Tw 0 -1.218 TD (\027\024\020\024 \026\027\026\035\017\026 \017)Tj /Span<>> BDC ( )Tj EMC (\027\036\r\024\n\024\032\027\024\f\021\034 \f\021\030\024\020\024\005 \r\ \026\035\017\007\026\006\017\017 )Tj 0.103 Tw 0 -1.218 TD (\027\026)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\034\001\024\n \004\017\f\035\036 \023\026\006\017\036\027\021\ \024\r \r)Tj /Span<>> BDC ( )Tj EMC (\f\017\035\031 \030\036\007\022\024\f\021\017 \f\026\n\024)Tj 0 Tw (-)Tj 0.145 Tw T* (\020\024 \f\024\f\021\024\016\027\017\016)Tj /Span<>> BDC ( )Tj EMC (\227 \n\036\020\026\022\024\035\024\027. \215\024\220\021\024\n\031 \n\t\ \027\026\n\036\030\036\027\027\024 )Tj 0.174 Tw T* (\023\030\036\007\035\026\020\026\036\n \017\f\023\024\035\034\024\r\026\ \021\034 \f\021\030\024\020\017\005 \022\030\017\021\036\030\017\005 \r\t\ \002\024\030\026 )Tj -0.015 Tw T* (\021\026\022\021\017\022\017 \035\036\004\036\027\017\016)Tj /Span<>> BDC ( )Tj EMC (\227 \r\036\030\024\016\021\027\024\f\021\034 \026\r\024\030\024\021\026\ \002\024\035\036\036 90%. )Tj 0.135 Tw T* (\221)Tj /Span<>> BDC ( )Tj EMC (\007\030\031\020\024\005 \f\021\024\030\024\027\t, \023\024\021\036\027\006\ \017\026\035\034\027\026\016 \021\016\032\036\f\021\034 \024\f\035\024\032\ \027\036)Tj 0 Tw (-)Tj 0.001 Tw 0 -1.218 TD (\027\017\005 \026\r\024\030\024\021\026 \023\024\r\024\035\016\036\021\ , \027\026)Tj /Span<>> BDC ( )Tj EMC (\027\026\001 \r\020\035\016\007, \017\f\023\024\035\034\024\r\026\021\034\ )Tj 0.035 Tw 0 -1.218 TD (\007\026\027\027\t\005 \022\030\017\021\036\030\017\005 \r)Tj /Span<>> BDC ( )Tj EMC (\024\023\030\036\007\036\035\036\027\017\017 \023\024\022\026\026\027\017\ \005 \022)Tj /Span<>> BDC ( )Tj EMC (\023\035\026\027\024)Tj 0 Tw (-)Tj 0.123 Tw 0 -1.218 TD (\r\024\n\031 \b\017\030\031\030\020\017\004\036\f\022\024\n\031 \035\036\ \004\036\027\017\033 \023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\017\007\017\024\023\026)Tj 0 Tw (-)Tj 0.068 Tw T* (\021\017\004\036\f\022\017\n \n\036\020\026\022\024\035\024\027. \215\030\ \017\n\036\027\036\027\017\036 \007\026\027\027\024\005 \027\024\n\024\020\ \030\026\n)Tj 0 Tw (-)Tj 0.081 Tw T* (\n\t \031\007\024\002\027\024 \036\013\036 \017)Tj /Span<>> BDC ( )Tj EMC (\021\036\n, \004\021\024 \r)Tj /Span<>> BDC ( )Tj EMC (\027\036\005 \031\004\017\021\t\r\026\033\021\f\016 \021\024\035\034\022\ \024 )Tj 0.145 Tw T* (\007\026\027\027\t\036 \017\030\030\017\020\024\f\022\024\023\017\017, \022\ \024\021\024\030\031\033 \r)Tj /Span<>> BDC ( )Tj EMC (\035\033\002\024\n \f\035\031\004\026\036 \006\036)Tj 0 Tw (-)Tj 0.043 Tw T* (\035\036\f\024\024\002\030\026\027\024 \r\t\023\024\035\027\016\021\034\ \035\017\006\026\n \f)Tj /Span<>> BDC ( )Tj EMC (\023\024\007\024\030\036\027\017\036\n \027\026)Tj /Span<>> BDC ( )Tj EMC (\n\036)Tj 0 Tw (-)Tj 0.091 Tw T* [(\020\026\022\024\035\024\027, )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 4.63 0 Td [(\024\f\027\024\r\027\024\036 )0.5(\027\026\004\036\027\017\036 )0.6(\r)]TJ /Span<>> BDC ( )Tj EMC 9.178 0 Td [(\027\036\005 )0.5(\017\n\036\033\021 )0.6(\030\026\n\036\030\t )]TJ 0.148 Tw -13.808 -1.218 Td (\023\030\016\n\024\005 \017)Tj /Span<>> BDC ( )Tj EMC (\f\017\020\n\024\r\017\007\027\024\005 \022\017\001\024\022, \022\024\021\ \024\030\t\036 \035\036\020\022\024 \017\n\036)Tj 0 Tw (-)Tj T* (\030\017\021\034 \023\030\026\022\021\017\004\036\f\022\017 \031)Tj /Span<>> BDC ( )Tj EMC (\r\f\036\b \023\026\006\017\036\027\021\024\r.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 275.0305 432.5578 Tm [(\020)21(\026\027\r\242\224\034\022\031\034)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0 Tc 0.319 Tw 10 0 0 10 274.9606 408.2018 Tm (\222\007\017\024\023\026\021\017\004\036\f\022\017\005 \n\036\020\026\022\ \024\035\024\027 \026\f\f\024\006\017\017\030\024\r\026\027 \f)Tj /Span<>> BDC ( )Tj EMC (\023\024\r\t)Tj 0 Tw (-)Tj 0.492 Tw T* (\001\036\027\027\t\n \030\017\f\022\024\n \030\026\r\017\021\017\016 \026\ \r\024\030\024\021\026 \f\017\020\n\024\r\017\007\027\024\005 )Tj 0.192 Tw T* (\022\017\001\022\017. \215\030\017)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\n, \f\024\020\035\026\f\027\024 \n\027\024\020\024\235\026\022\ \021\024\030\027\024\n\031 \035\024\020\017)Tj 0 Tw (-)Tj 0.495 Tw T* [(\f\021\017\004\036\f\022\024\n\031 )0.6(\030\036\020\030\036\f\f\017\024\027\027\024\n\031 )0.5(\026\027\026\035\017\031, )0.6(\027\026\017\002\024\035\034\001\036\036 )]TJ 0.36 Tw T* (\027\026\004\036\027\017\036 \f)Tj /Span<>> BDC ( )Tj EMC (\021\024\004\022\017 \030\036\027\017\016 \024\006\036\027\022\017 \030\ \017\f\022\026 \026\r\024\030\024\021\026 )Tj 0.182 Tw T* (\017\n\036\033\021 \001\017\030\017\027\026 \023\030\016\n\024\005 \017)Tj /Span<>> BDC ( )Tj EMC (\f\017\020\n\024\r\017\007\027\024\005 \022\017\001\024\022. \217\017\f\022\ )Tj 0.233 Tw T* [(\026\r\024\030\024\021\026 )0.5(\002\024\035\036\036 )0.6(90%, )0.5(\024\006\036\027\036\027\027\t\005 )0.6(\023\024)]TJ /Span<>> BDC ( )Tj EMC 16.005 0 Td (\023\030\036\007\035\024\032\036\027\027\024\005 )Tj 0.375 Tw -16.005 -1.218 Td (\027\024\n\024\020\030\026\n\n\036, \n\024\032\027\024 \030\026\f\f\n\026\ \021\030\017\r\026\021\034 \022\026\022 \023\024\022\026\026\027\017\036\ )Tj 0.093 Tw T* (\022)Tj /Span<>> BDC ( )Tj EMC (\023\035\026\027\024\r\024\n\031 \b\017\030\031\030\020\017\004\036\f\022\ \024\n\031 \r\n\036\001\026\021\036\035\034\f\021\r\031 \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017)Tj 0 Tw (-)Tj 0.21 Tw T* (\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\017\007\017\024\023\026\021\017\004\036\f\022\017\n \n\036\020\026\022\024\ \035\024\027 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\024\021\f\031\021\f\021\r\017\017 )Tj 0 Tw T* (\026\r\024\030\024\021\026 \r)Tj /Span<>> BDC ( )Tj EMC (\026\027\026\n\027\036\036.)Tj /T1_3 1 Tf 0.023 Tw 0 -2.436 TD (\223\030\032\255\020\034\036 \032\026\020\017\022\017\026)Tj /T1_1 1 Tf 0.346 Tw 0 -1.218 TD [(\025)-4.1(\024)-4.3(\027)1.7(\006)-6(\036)-6.8(\023)2.2(\006)-6(\017)-5.4(\016 \017)]TJ /Span<>> BDC ( )Tj EMC [(\007)-6(\017)2.7()-9.9(\026\005)1.6(\027 \017)-2.4(\f)3.1(\f)-38.9(\035)-6.7(\036)-19(\007)-4.4(\024)-4.3(\r)-8.9(\026\027)1.7(\017)-5.5(\016)13.7(:)]TJ /T1_4 1 Tf [( \201)-17.3(\023)3.3(\031)4.9(\001)9.6(\025)7.2(\021)]TJ /Span<>> BDC ( )Tj EMC [(\200)1.4(.)28.5(\216)24.3(.)7.8(, )]TJ -0.029 Tc 0.029 Tw T* [(\201\006)-18.3(\013)-16.3(\026)-28.6(\t)-19.2(\n)-19.4(\027)]TJ /Span<>> BDC 3.201 0 Td ( )Tj EMC [(\207)-31.1(.\215.)]TJ /T1_1 1 Tf 0 Tc 0 Tw -3.201 -1.218 Td [(\221)-4.6(\002)-9.9(\024)0.7(\030 \017)]TJ /Span<>> BDC ( )Tj EMC [(\024)-11.8(\002)3(\030)-11.3(\026)-6.4(\002)-9.9(\024)-10.8(\021)-17.7(\022)-19.1(\026 \n)1.3(\026)-11.8(\021)-9.9(\036)-1.7(\030)-7.6(\017)-0.6(\026)-33.1(\035)-2.5(\024)-4.3(\r)10.4(:)]TJ /T1_4 1 Tf -0.028 Tc 0.028 Tw [( \201)-45.2(\023)-24.7(\031)-23.1(\001)-18.4(\025)-20.8(\021)]TJ /Span<>> BDC 16.153 0 Td ( )Tj EMC [(\200)-26.6(.)0.5(\216)-3.7(.)]TJ /T1_1 1 Tf 0.018 Tc 1.732 Tw -16.153 -1.218 Td [(\221)35.2(\021)-3.5(\026)6.2(\021\017)15.6(\f)-18(\021\017)22.5(\004)9.8(\036)7.6(\f)16.4(\022)-1.1(\026)-3(\016)18( \024)6.2(\002)21(\030)6.6(\026)11.7(\002)8.1(\024)7.1(\021\022)-1.1(\026)21.7(:)]TJ /T1_4 1 Tf 0 Tc 1.75 Tw 13.099 0 Td [( \201)-17.3(\023)3.3(\031)4.9(\001)9.6(\025)7.2(\021)]TJ /Span<>> BDC ( )Tj EMC [(\200)1.4(.)28.5(\216)24.3(.)7.8(, )]TJ -0.002 Tc 0.002 Tw -13.099 -1.218 Td [(\215)21.2(\202)5.3(\021)7.5(\026\024)2.1(\031\021)8.7(\013)7.8(\n)]TJ /Span<>> BDC 4.527 0 Td ( )Tj EMC [(\240)17.4(.)5.3(\201)-4.3(.)5.8(,)-1.9( )6.8(\n)3.3(\021)1.8(\n\003)4.9(\026\032)-1.9(\031\021)8.7(\013)7.8(\n)]TJ /Span<>> BDC 7.803 0 Td ( )Tj EMC [(\201)-4.3(.)5.3(\201)-4.3(.)]TJ /T1_1 1 Tf 0.002 Tc -0.002 Tw -12.33 -1.218 Td [(\203)7.2(\026\023)4.2(\017\f)-10.8(\026)1.7(\027)3.7(\017)-6.7(\036)2.1( \021)-7.9(\036)-3.4(\022\f)-34(\021)-19.5(\026)5.7(:)]TJ /T1_4 1 Tf -0.028 Tc 0.028 Tw 7.694 0 Td [( \201)-45.3(\023)-24.7(\031)-23.1(\001)-18.4(\025)-20.7(\021)]TJ /Span<>> BDC 3.413 0 Td ( )Tj EMC [(\200)-26.6(.)0.5(\216)-3.7(.)]TJ /T1_1 1 Tf 0 Tc 0 Tw -11.107 -1.218 Td [(\217)5.5(\036)-19(\007)-20.1(\026\022)-32.6(\021)-17.7(\017)1.5(\030)-11.8(\024)-4.4(\r)-8.8(\026\027)1.8(\017)-8.7(\036)6.5(:)]TJ /T1_4 1 Tf -0.029 Tc 1.099 Tw [( \201\006)-18.3(\013)-16.3(\026)-28.6(\t)-19.2(\n)-19.4(\027)]TJ /Span<>> BDC 11.639 0 Td ( )Tj EMC [(\207)-31.1(.\215.)-21.2(,)-29( \207)-1.4(\205)-19.7(\001)-21.8(\013)-19.2(\n)-19.4(\027)]TJ /Span<>> BDC 7.314 0 Td ( )Tj EMC [(\255)-1.4(.\215.)-21.2(,)-29( )]TJ 0 Tc 0.382 Tw -18.953 -1.218 Td [(\231)14.1(\026)-14.4(\004)-1.9(\003)6.9(\026)1.9(\024)4(\n)9.6(\027)]TJ /Span<>> BDC ( )Tj EMC [(\200)1.4(.)29.3(\210)122(.)7.9(, \207)27.6(\205)-4.3(\032\n)9.6(\027)-0.8(\031)0.7(\202)10(\025)7.2(\021)]TJ /Span<>> BDC ( )Tj EMC [(\036)22.8(.)43.7(\207)-2.1(.)7.8(, )0.5()8.8(\n)5.3(\021)3.8(\n)2.4(\003)7(\026)1.8(\032\031)2.3(\021)10.7(\013)9.8(\n)]TJ /Span<>> BDC ( )Tj EMC 20.249 0 Td [(\201)-2.3(.)7.3(\201)-2.3(.)7.8(, )]TJ -0.027 Tc 0.027 Tw -20.249 -1.218 Td [(\225)-23.1(\n)-24.6(\003)-23(\031)-24.6(\021)-16.3(\013)-17.2(\n)]TJ /Span<>> BDC 3.509 0 Td ( )Tj EMC [(\255)0.6(.)0.5(\223.)]TJ /T1_3 1 Tf 0 Tc 0.023 Tw -3.509 -2.436 Td (AUTHORS CONTRUBUTION)Tj /T1_1 1 Tf 0.274 Tw T* [(C)-6.5(o)0.8(nce)-0.7(p)-12.3(t a)2.4(n)-4.6(d d)-5.5(e)-13.3(s)-16.6(i)3.2(g)1.2(n o)-2.2(f t)-16.7(h)-5.3(e s)-20(t)-12.8(ud)-10.9(y)-11.8(:)]TJ /T1_4 1 Tf [( D)-6.1(e)-2.6(n)6.2(i)11(s)]TJ /Span<>> BDC ( )Tj EMC [(V)53.1(.)]TJ /Span<>> BDC ( )Tj EMC [(A)3.6(l)4.8(e)-17.9(s)9.6(h)6.2(i)8.4(n)-6(, )]TJ -0.002 Tc 0.002 Tw T* [(S)3.6(e)-3.7(rg)-4.5(e)-4.5(y)]TJ /Span<>> BDC 2.567 0 Td ( )Tj EMC (I.)Tj /Span<>> BDC 0.864 0 Td ( )Tj EMC [(A)-1.1(ch)5.5(k)13.8(a)-4.9(s)2.9(o)-2.6(v)]TJ /T1_1 1 Tf 0 Tc 0 Tw -3.43 -1.218 Td [(P)-8.9(r)-6(o)-7(ce)-13.3(s)-12.8(s)-16.6(i)7.2(n)-1.9(g o)-2.2(f t)-16.7(h)-5.3(e m)1.8(a)-8.4(t)-15.2(e)-2(r)-48(i)5.1(a)-1.5(l)-22.5(:)]TJ /T1_4 1 Tf -0.006 Tc 0.006 Tw [( D)-12.1(e)-8.6(ni)5.1(s)]TJ /Span<>> BDC 13.287 0 Td ( )Tj EMC [(V)47.1(.)]TJ /Span<>> BDC 0.955 0 Td ( )Tj EMC [(A)-2.4(l)-1.2(e)-24(s)3.7(hi)2.4(n)]TJ /T1_1 1 Tf 0 Tc 0 Tw -14.242 -1.218 Td [(W)3.1(r)-48(i)-6(t)-37.4(i)7.1(n)-1.9(g o)-2.2(f t)-16.7(h)-5.3(e t)-15.2(e)-23.9(x)-36(t)-20(:)]TJ /T1_4 1 Tf -0.006 Tc 0.006 Tw [( D)-12.1(e)-8.6(ni)5(s)]TJ /Span<>> BDC 10.254 0 Td ( )Tj EMC [(V)47.1(.)]TJ /Span<>> BDC 0.955 0 Td ( )Tj EMC [(A)-2.4(l)-1.2(e)-24(s)3.7(hi)2.4(n)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 0 Tc 0 Tw 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\033\030\031\030\213\b)-20.9(\035\231\213\233\t \021\032)50(\b)42(\032\231\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj /T1_5 1 Tf 25 0 0 25 512.8268 56.0378 Tm (39)Tj ET endstream endobj 2223 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.094 Tw 10 0 0 10 70.8661 724.8299 Tm (\023\024\007\021\r\036\030\032\007\036\027\017\036\n \023\024\r\t\001\036\ \027\027\024\020\024 \030\017\f\022\026 \026\r\024\030\024\021\026 \031\ )Tj /Span<>> BDC ( )Tj EMC (\023\026)Tj 0 Tw (-)Tj 0.118 Tw 0 -1.218 TD (\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\017\007\017\024\023\026\021\017\004\036\f\022\017\n \n\036\020\026\022\024\ \035\024\027 \f\035\031\032\017\021 \017)Tj /Span<>> BDC ( )Tj EMC (\027\026\001 )Tj 0.025 Tw T* (\f\024\002\f\021\r\036\027\027\t\005 \024\023\t\021, \r)Tj /Span<>> BDC ( )Tj EMC (\004\026\f\021\027\024\f\021\017, \021\024\021 \235\026\022\021, \004\021\ \024 \026\r\024\030\024\021 )Tj 0.138 Tw T* (\017\n\036\035 \n\036\f\021\024 \002\024\035\036\036, \004\036\n \031)Tj /Span<>> BDC ( )Tj EMC (30% \002\024\035\034\027\t\b \r)Tj /Span<>> BDC ( )Tj EMC (\027\026\f\021\024\016\013\036\n )Tj 0.188 Tw T* (\017\f\f\035\036\007\024\r\026\027\017\017. \222)Tj /Span<>> BDC ( )Tj EMC (\220\021\024 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\021\024\n, \004\021\024 \n\t \027\036 \r\022\035\033\004\026\035\017 )Tj 0.027 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\026\027\026\035\017 \023\026\006\017\036\027\021\024\r, \022\024\021\024\ \030\t\n \007\024)Tj /Span<>> BDC ( )Tj EMC (\024\002\030\026\013\036\027\017\016 \r)Tj /Span<>> BDC ( )Tj EMC (\022\035\017\027\017)Tj 0 Tw (-)Tj 0.185 Tw 0 -1.218 TD (\022\031 \r\t\023\024\035\027\016\035\017\f\034 \030\036\036\022\006\017\ \017 \022\017\001\022\017 \f)Tj /Span<>> BDC ( )Tj EMC (\235\024\030\n\017\030\024\r\026\027\017\036\n )Tj 0.092 Tw 0 -1.218 TD (\022\024\035\024\f\021\024\n\t, \004\026\013\036 \r\f\036\020\024, \022\026\ \022 \030\026 \023\024)Tj /Span<>> BDC ( )Tj EMC (\023\024\r\024\007\031 \026\r\024\030\024\021\026. )Tj 0.38 Tw T* (\222\n\036\027\027\024 \026\r\024\030\024\021 \016\r\035\016\036\021\f\016\ \024\f\027\024\r\027\t\n \023\030\024\016\r\035\036\027\017\036\n )Tj 0.082 Tw T* (\024\f\035\024\032\027\036\027\027\024\020\024 \021\036\004\036\027\017\016\ \n\036\020\026\022\024\035\024\027 \017, \f\024\024\021\r\036\021\f\021\ \r\036\027\027\024, )Tj 0.217 Tw T* (\023\024\022\026\026\027\017\036\n \022)Tj /Span<>> BDC ( )Tj EMC [(\023\035\026\027\024\r\024\n\031 \b\017\030\031\030\020\017\004\036\f\022\ \024\n\031 )0.5(\035\036\004\036\027\017\033. )]TJ 0.308 Tw T* (\203\024 \n\036\020\026\022\024\035\024\027 \024\f\035\024\032\027\016\036\ \021\f\016 \026\r\024\030\024\021\026\n\017 \027\036 \r\f\036\020\007\026\ , )Tj 0.08 Tw 0 -1.218 TD (\017)Tj /Span<>> BDC ( )Tj EMC (\027\026 \f\036\020\024\007\027\016\001\027\017\005 \007\036\027\034 \024\ \f\027\024\r\027\t\n \023\030\017\027\026\022\024\n, \027\026)Tj /Span<>> BDC ( )Tj EMC (\022\024)Tj 0 Tw (-)Tj 0.092 Tw 0 -1.218 TD (\021\024\030\t\005 \n\t \024\030\017\036\027\021\017\030\031\036\n\f\016\ \r)Tj /Span<>> BDC ( )Tj EMC (\024\006\036\027\022\036 \030\017\f\022\026 \036\020\024 \030\026\r\017\ )Tj 0 Tw (-)Tj 0.048 Tw 0 -1.218 TD (\021\017\016, \016\r\035\016\036\021\f\016 \027\026\035\017\004\017\036 \ \026\r\024\030\024\021\026 \r)Tj /Span<>> BDC ( )Tj EMC (\026\027\026\n\027\036\036. \215\024\220\021\024\n\031 )Tj 0.008 Tw T* (\027\026\n \023\030\036\007\f\021\026\r\035\016\035\024\f\034 \006\036\035\ \036\f\024\024\002\030\026\027\t\n \023\024\023\t\021\026\021\034\f\016\ \r\t)Tj 0 Tw (-)Tj 0.25 Tw T* (\016\r\017\021\034 \007\024\023\024\035\027\017\021\036\035\034\027\t\036\ \235\026\022\021\024\030\t \030\017\f\022\026, \027\026)Tj /Span<>> BDC ( )Tj EMC (\022\024\021\024\030\t\036 )Tj 0.03 Tw T* (\n\024\032\027\024 \002\t\035\024 \002\t \024\023\017\030\026\021\034\f\016\ \r)Tj /Span<>> BDC ( )Tj EMC (\r\t\002\024\030\036 \021\026\022\021\017\022\017 \035\036\004\036\027\017\ \016 )Tj 0 Tw T* (\n\036\020\026\022\024\035\024\027/\n\036\020\026\030\036\022\021\031\n \ \036\013\036 \007\024)Tj /Span<>> BDC ( )Tj EMC (\030\026\r\017\021\017\016 \024\f\035\024\032\027\036\027\017\016.)Tj 0.496 Tw T* (\215\030\017\n\036\027\017\021\036\035\034\027\024 \022)Tj /Span<>> BDC ( )Tj EMC (\023\024\035\024-\r\024\030\026\f\021\027\t\n \024\f\024\002\036\027\027\ \024\f\021\016\n )Tj 0.126 Tw T* (\023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\026\r\024\030\024\021\024\n \r)Tj /Span<>> BDC ( )Tj EMC (\035\017\021\036\030\026\021\031\030\036 \024\023\017\f\026\027\024 \f\031\ \013\036)Tj 0 Tw (-)Tj 0.063 Tw T* [(\f\021\r\036\027\027\024\036 )0.6(\(2\2264-\b )0.5(\022\030\026\021\027\024\036\) )0.5(\023\030\036\024\002\035\026\007\026\027\017\036 )0.6(\n\031\032\004\017\027 )0.6(\027\026\007 )]TJ 0.053 Tw T* (\032\036\027\013\017\027\026\n\017 [1,8,10]. \215\030\017)Tj /Span<>> BDC ( )Tj EMC (\027\026\035\017\004\017\017 \n\036\020\026\022\024\035\024\027 \f\021\026\ \021\017\f)Tj 0 Tw (-)Tj -0.035 Tw T* [(\021\017\004\036\f\022\017 )0.5(\027\026\004\017\n\t\b )0.5(\030\026\035\017\004\017\005 )0.5(\023\024)]TJ /Span<>> BDC ( )Tj EMC [(\023\024\035\031 )0.5(\031)]TJ /Span<>> BDC ( )Tj EMC [(\023\026\006\017\036\027\021\024\r )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC (\026)Tj 0 Tw (-)Tj 0.011 Tw T* [(\r\024\030\024\021\024\n )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 4.432 0 Td [(\002\036 )0.5(\027\026\n )0.5(\024\002\027\026\030\031\032\017\021\034 )0.6(\027\036 )0.5(\031\007\026\035\024\f\034. )0.6(\215\026\006\017\036\027\021\t )]TJ 0.251 Tw -4.432 -1.218 Td (\f)Tj /Span<>> BDC ( )Tj EMC (\026\r\024\030\024\021\024\n \r)Tj /Span<>> BDC ( )Tj EMC (\026\027\026\n\027\036\036 \002\t\035\017 \007\024\f\021\024\r\036\030\027\ \024 \f\021\026\030\001\036. )Tj 0.081 Tw T* (\203\024 \r)Tj /Span<>> BDC ( )Tj EMC (\021\024\032\036 \r\030\036\n\016 \f\030\036\007\027\017\005 \r\024\030\ \026\f\021 \017\b \f\024\f\021\026\r\017\035 \r\f\036\020\024 )Tj 0.087 Tw T* (34 \020\024\007\026, \004\021\024, \r)Tj /Span<>> BDC ( )Tj EMC (\006\036\035\024\n, \b\026\030\026\022\021\036\030\027\024 \007\035\016 \ \253\220\027\007\036\n\017\004\027\t\b\273 )Tj -0.036 Tw T* (\023\024)Tj /Span<>> BDC ( )Tj EMC (\026\r\024\030\024\021\031 \f\021\030\026\027 \f\r\036\021\026, \r)Tj /Span<>> BDC ( )Tj EMC (\024\021\035\017\004\017\036 \024\021 \221\234\202 \017)Tj /Span<>> BDC ( )Tj EMC (\003\026\023\026\007\027\024\005 )Tj 0.282 Tw 23.244 34.098 Td (\213\r\030\024\023\t, \020\007\036 \026\r\024\030\024\021 \004\026\013\036\ \r\f\021\030\036\004\026\036\021\f\016 \031)Tj /Span<>> BDC ( )Tj EMC (\023\024\032\017\035\t\b )Tj 0 Tw T* (\023\026\006\017\036\027\021\024\r.)Tj 0.13 Tw T* [(\223\021\024 )0.5(\022\026\f\026\036\021\f\016 )0.6(\022\035\017\027\017\004\036\f\022\024\005 )0.5(\022\026\030\021\017\027\t, )0.5(\021\024 )0.5(\002\024\035\034\001\017\027\f\021\r\024 )]TJ 0.262 Tw T* [(\023\026\006\017\036\027\021\024\r )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC [(\017\007\017\024\023\026\021\017\004\036\f\022\017\n )0.5(\n\036\020\026\022\024\035\024\027, \022\026\022 )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC (\026)Tj 0 Tw (-)Tj 0.106 Tw T* (\r\024\030\024\021\024\n, \021\026\022 \017)Tj /Span<>> BDC ( )Tj EMC [(\002\036, \023\030\036\007\255\016\r\035\016\035\017 )0.5(\032\026\035\024\002\t \027\026)]TJ /Span<>> BDC ( )Tj EMC (\026\023\024\030\t, )Tj 0.048 Tw T* [(\004\021\024 \f\024\024\021\r\036\021\f\021\r\031\036\021 )0.5(\007\026\027\027\t\n )0.5(\035\017\021\036\030\026\021\031\030\t. )0.5(\230\036\n \027\036 )0.5(\n\036\027\036\036, )]TJ 0.266 Tw 0 -1.218 TD (\r\024\n\024\032\027\024\f\021\034 \f\026\n\024\f\021\024\016\021\036\035\ \034\027\024\005 \007\036\235\036\022\026\006\017\017, \b\024\021\016 \002\ \t )Tj 0.268 Tw 0 -1.218 TD (\023\036\030\017\024\007\017\004\036\f\022\017, \f\024\b\030\026\027\016\ \035\026\f\034 \031)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\034\001\017\027\f\021\r\026 \017)Tj /Span<>> BDC ( )Tj EMC (\027\017\b, )Tj 0.105 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\f\031\013\036\f\021\r\036\027\027\t\b \030\026\035\017\004\017\005 \023\ \024)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\n\031 \023\030\017\027\026\022\031 \n\036\032\007\031 )Tj 0.02 Tw T* [(\020\030\031\023\023\026\n\017 )0.5(\n\t )0.6(\027\036 )0.5(\024\002\027\026\030\031\032\017\035\017. )0.6(\230\026\022\032\036 )0.5(\027\036 )0.5(\002\t\035\024 )0.6(\r\t\016\r\035\036)]TJ 0 Tw (-)Tj 0.042 Tw T* (\027\024 \f\021\026\021\017\f\021\017\004\036\f\022\017 \027\026\004\017\ \n\t\b \030\026\035\017\004\017\005 \027\017 \r)Tj /Span<>> BDC ( )Tj EMC (\017\027\021\036\027\f\017\r)Tj 0 Tw (-)Tj 0.088 Tw T* (\027\024\f\021\017 \r\007\031\021\017\016 \032\017\r\024\021\026 \r)Tj /Span<>> BDC ( )Tj EMC (\004\026\f\021\027\024\f\021\017, \027\017 \r)Tj /Span<>> BDC ( )Tj EMC (\r\t\030\026\032\036\027\027\024)Tj 0 Tw (-)Tj 0 -1.218 TD (\f\021\017 \026\002\007\024\n\017\027\026\035\034\027\024\020\024 \007\017\ \f\022\024\n\235\024\030\021\026 \r)Tj /Span<>> BDC ( )Tj EMC (\006\036\035\024\n.)Tj 0.25 Tw 0 -1.218 TD (\207\024\035\036\036 \021\024\020\024, \007\035\016 \023\026\006\017\036\ \027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\026\r\024\030\024\021\024\n \r)Tj /Span<>> BDC ( )Tj EMC (\026\027\026\n\027\036)Tj 0 Tw (-)Tj 0.39 Tw 0 -1.218 TD (\036 \002\t\035\026 \b\026\030\026\022\021\036\030\027\026 \007\024\f\021\ \024\r\036\030\027\024 \002\024\035\034\001\026\016 \004\026\f\021\024\021\ \026 )Tj 0.484 Tw T* (\007\036\235\036\022\026\006\017\017 \017)Tj /Span<>> BDC ( )Tj EMC (\n\036\027\034\001\026\016 \r\t\030\026\032\036\027\027\024\f\021\034 \023\ \024\022\026\026\021\036\035\016 )Tj 0.168 Tw T* (\253\030\026\f\f\021\030\024\005\f\021\r\024 \007\036\235\036\022\026\006\ \017\017\273. \222\027\021\036\027\f\017\r\027\024\f\021\034 \026\023\024\ \030\024\r )Tj 0.163 Tw T* (\023\024)Tj /Span<>> BDC ( )Tj EMC (\001\022\026\035\036 \200\036\022\f\027\036\030\026 \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\026\r\024\030\024\021\024\n \021\026\022\032\036 )Tj 0 Tw T* (\002\t\035\026 \f\021\026\021\017\f\021\017\004\036\f\022\017 \027\026\004\ \017\n\024 \n\036\027\034\001\036.)Tj 0.099 Tw T* (\200 \024\021\027\024\001\036\027\017\017 \007\017\026\020\027\024\f\021\ \017\004\036\f\022\017\b \021\036\f\021\024\r, \f\024\020\035\026\f\027\024\ \031\027\017)Tj 0 Tw (-)Tj 0.206 Tw T* (\r\026\030\017\026\027\021\027\024\n\031 \026\027\026\035\017\031, \030\ \017\f\022 \026\r\024\030\024\021\026 \002\t\035 \f\021\026\021\017\f\021\ \017)Tj 0 Tw (-)Tj 0.263 Tw T* (\004\036\f\022\017 \027\026\004\017\n\024 \026\f\f\024\006\017\017\030\024\ \r\026\027 \f)Tj /Span<>> BDC ( )Tj EMC (\030\026\n\036\030\026\n\017 \023\030\016\n\024\005 )Tj 0.419 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\f\017\020\n\024\r\017\007\027\024\005 \022\017\001\024\022 \023\024)Tj /Span<>> BDC ( )Tj EMC (\007\026\027\027\t\n \017\030\030\017\020\024\f\022\024\023\017\017. )Tj 0.139 Tw T* (\215\030\017\004\036\n \007\035\017\027\026 \017)Tj /Span<>> BDC ( )Tj EMC (\001\017\030\017\027\026 \f\017\020\n\024\r\017\007\027\024\005 \022\017\ \001\022\017 \023\030\016\n\024 )Tj 0.151 Tw T* (\022\024\030\030\036\035\017\030\024\r\026\035\017 \f)Tj /Span<>> BDC ( )Tj EMC (\004\026\f\021\024\021\024\005 \026\r\024\030\024\021\026, \026)Tj /Span<>> BDC ( )Tj EMC (\001\017\030\017\027\026 \023\030\016)Tj 0 Tw (-)Tj T* (\n\024\005 \022\017\001\022\017)Tj /Span<>> BDC ( )Tj EMC (\227 \024\002\030\026\021\027\024 \023\030\024\023\024\030\006\017\024\027\ \026\035\034\027\024.)Tj 0.357 Tw T* (\223\021\024 \022\026\f\026\036\021\f\016 \030\036\031\035\034\021\026\021\ \024\r \007\030\031\020\017\b \007\017\026\020\027\024\f\021\017\004\036\ \f\022\017\b )Tj 0.195 Tw T* (\021\036\f\021\024\r)Tj /Span<>> BDC ( )Tj EMC (\227 \024\002\013\036\020\024 \r\030\036\n\036\027\017 \021\030\026\027\ \017\021\026 \023\024)Tj /Span<>> BDC ( )Tj EMC (\240\025\230, \023\026\030\026)Tj 0 Tw (-)Tj 0.032 Tw T* (\n\036\021\030\024\r \007\036\235\036\022\024\020\030\026\235\017\017 \017\ )Tj /Span<>> BDC ( )Tj EMC (\017\f\f\035\036\007\024\r\026\027\017\016 \030\036\036\030\r\031\026\030\ \027\024\005 )Tj ET q /GS0 gs 453.543294 0 0 240.6899062 70.8661499 122.6304673 cm /Im0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0 Tw 10 0 0 10 524.4094 122.5959 Tm ( )Tj -0.034 Tw 9 0 0 9 70.8661 111.7959 Tm (\022\t\217\210\b\002\220 2.)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf ( \217\n\003\n\202\032\026\003\003\026 \033\032\n\202\021\n\016\025\032\n\ \027\026\021\025\002 \032\025\t\013\026 \016\026\027\n\032\n\024\026 \t\025\ \202\003\n\027\025\030\021\n\017 \013\025\001\013\025 \205)Tj /Span<>> BDC ( )Tj EMC (\033\026\203\025\031\021\024\n\027 \t)Tj /Span<>> BDC ( )Tj EMC (\025\030\025\n\033\026\024\025\006\031\t\013\025\003 \003\031\202\026\013\ \n\023\n\021/)Tj 0 Tw 0 -1.2 TD (\003\031\202\026\032\031\013\024\205\003 \033\n)Tj /Span<>> BDC ( )Tj EMC (\032\026\016\003\031\032\026\003 \033\032\002\003\n\017 \025)Tj /Span<>> BDC ( )Tj EMC (\t\025\202\003\n\027\025\030\021\n\017 \013\025\001\n\013)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0.002 Tw T* [(F)-16(igure 2)15.9(.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf [( N)17(omog)14.1(ram p)46(redicting the r)-37(isk of sigmoid v)13(olvulus in patients with idiopathic meg)12(acolon/meg)12(arectum by the size of the )]TJ 0 Tw T* (rectum and sigmoid colon)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\033\030\031\030\213\b)-20.9(\035\231\213\233\t \021\032)50(\b)42(\032\231\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj -51.938 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 23, \023\0221)69(, 202)69(4)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 23, \023\0221)69(, 202)69(4)]TJ /T1_4 1 Tf 25 0 0 25 28.115 56.0378 Tm (38)Tj ET endstream endobj 2224 0 obj <>stream AdobedC     '$''''$25552;;;;;;;;;;w   C9!1AT"QUaq#23BCc $%&'()*456789:DEFGHIJRSVWXYZbdefghijrstuvwxyz?ЪѪҪӪ\mz5ښ ]r[*ujj㨊/GDln5G+6=6dM5c%D~E\eS)Mn+갧BWdVD\V6Ujܭ&ZQxSֲ͞5I:Gis%d,r<)TEgmՉpFtDˣÍ6HԪan[%-~m[9a=Qee±:rQ%m4^MS܉_EŽZ)Q7EUŠ *d[oֺItM&9\&pDL#Q0{^{Tfۖs)alpƿٷ tSZfJ,nbK5c-*d7s(8h]+Lu+euMSWrM<.Fj'ܽG,诒G+UUUS4t6䧆*9cZX3,Q)܈ P~:vlJ7O3:r[ED٭7&DuյdA":Es_3t[}{mڋP~:vڲka"7-aӳ[nMCSBtNGAM8P~:նIh+ul̚ەvkwMɨ|Q?rhbXǯ(W+\c;5>(Nvv"HGGU\gD] ٭7&Dy_OWܡjhSSO4:>Xݥխ7&Du۫t5WktQQ= P~:պXhƫ̺hL6.ӳ[nMC۫rǪ=_y.[gvkwMɨ|Q?rZ}:ښt5Kg:h=ZrjOܧ\[тY~r+ L-EO'ftܚ);V`'1tyq3ŜrjOܧ\[{ )FHk6.3]cm5'S2 = us3EL8QGZ:8)5/CZ]:gA^|V9O@**5:x |lLlPHkQ'"m\t6̯[nMC۫d-dK"'Tf"\rjOܧ\[!k'Y:1{%2P~<X4/O1h^ ,n5'SnrM =TfVe6&aЯDtDnCqn5'SKuz=MV͝,K= ;5>(N- V#͝,<0vkwMɨ|Q?rnvxhZ|z\my;5>(O,O_Nx:"~\.sZ>z>(N>%5U"7= j;5>(N>'G ת|nٵQsrjOܧ\[њh#Tr;IS}{lqrjOܧtjj[}{' P~:vh"zpg 8Sa٭7&Duվ%lDY~S L)P~8L> 49ghS-6/ɲnz\m^3 |sLz2't[-QC'CZkQ:ih"78eBɺl.)Qx'SS!c'YƣIb9ț]\exn5'Sn#gWzO32JeL!٭7&Duղ$lPJ/IfQUU L ;5>(N5%]$tn]=TӫbsƤ"+_4{֪`nVߒg {*,tV{$=e$nYDkv^7A]YnWӹmMS{t\ǹU]&ݛv{lz9U,nr@Gi r inVF,u0ǤK#_]j#lJnv1nG9tWc9ك;}ƚULl RF|XtHC!dk-%W#sڊ\*S>תЪѪҪӪԪժuMUMM8tsYp*膪= 4shKV{ô4,{[DWQ4Qx{Ø֪k[Ea\cebᐢ*SN6:: _)`*G U&ᨈyݵֈ/FQXI]N5L+1+#Jزts&aUFm:кeSv㉥x;g*S֒Iw*I ̵̲(F+vWكtų\VFNʖn1+}ճ1Ү#$*1US6h#mZjEflJ*564r*S w7[ kHVYr#R?\JeQQgm{\,̵j*auB"sUuzVgݜ=nju$dWcefG6qiwg%eSMot s${sjh0}݋- שY+UlF\¡颿 nJ*Zg;j~GXqUȼwQnZ IKj|pѤUX˧F\ eeuS Lj9ǐjmֺ{U=[FK$J-Ziy8xgt0P]nf0ڥIQ㭊FƬ۱sEB+-UDղ{D\5&QrL uS["uC Z偉$d/vxzۮpڠmgK42;ȣG\PCl.;ksJ*43 vlDnULb;k$c对*#QUYozkVev,ԅIw\ŷf4մﱲKdOO3顎KV%%tʬDW+z*lC=|QW:K$Dz"iaSi鴶MP毯 kj^ȣVF>6WljC IiUn6GoZ?N63*SjM{;wMYYQ$|Ne=L>"v07FnbC źvV4I$JEU#W)ܷ12ޫmUT-^jXj撣,h\"̞EoRXkZa&S6IsQnrcuQ9V˼ԬT_TΏj=QM s,t{1smaQR&" e->53-l=n#bg3\7M5uGDR/@ԤކD^6ynwJtt,th~!~馧M5DV43/qp3!OG؉3ڪn/>)]Jt$7B3IQQ_'&LЪx-Kz:DW5Lqu٭Qx,GcDMIUó@ ?tK{=5 $EK.qΊpξWqI:*W;VOR׵֢.p)k[iu>YW\QcvEʉ}ez䚶G5;`V3Gb*"\6Ӫjm.7JVƕTE2/WM;{_ަSoy=n;]ELct~Ց\ !]^arSӳtﺲ%#k9EvNQGmz65]괵s:t;ltY誑G*>WVQx>oi̻=(f=YkpitɰZm4wlԆZWA([ˀԪժ֪תuE:-&%XtXUVsN-|rs)L{U=k8j/)c6M $r5DZQs\G"QQQv)VѳX&^ښGA۱]EЪk?Mcm_ϕ=V+X]MUUEn8QVx =MGRIȈEE|42W.گqR)%U_ aSb:rtէk+$S""{YU %mmtmkhFz*#Y>6M^.VuTMUR@$=9{&jⲺr8+-΅$=e홪9cW(u^nz{ 4S:FHc&vrtT{VW5I){!ʎ(CG/DSMSM%4;U n,gV۔ؼG}ѥJ*8Ҳ6k}SYRTHó{mu5۞3U`s"FpedSKDق41Rj%J"f32&<料^)4(iᦔJ~M&3E¦Qp`K-]8UʹiGȍ{{,b*,$SI CEe*'i5>wѪj -{uJ*ʚy,RSRԑ'V5Q bAkRIkk.5EP=Fͼ' =w5AO [/AN{u,UkƧ -E/RSҹ6b6+V8H[ Qr[ᝊJn\U4T^ǩs杚DEUW&=wqY&:Yh7NJ ii={`sT=^*.vT1؅RL,oDE,ԷFVSQͩtX5bUbUvx F_q.^[e%Dt.d\IsU\*S&B۰6'|X:-U vm%)ߤ[kXtV*EErc<Uj;4rʕ%Yjf~]=WIpsk"[,Y$殮gjV%WmFNU}ڂOYuZe}\V-2#Hm3ݝR#܊G>.+jK|r2->tG*aUpvY*+7KvTTUYhȘ^׮U6cQX.oUң)9I&F*G5 "mcRsiG5S DTT= jjCd=3}"H㈋NSQ8޻<sSQ8޻<sSQ8޻<sSQ9%˭B:,jy>s⧚qw>jy>s槚qw>*y>s槚s}}EK'2&HħrEGcbW T;O5Gz}TT}7O5Gz}TT}7O5Gz}T}7O5GEUҚQ#_PV*>=<`t޻5<sSQ8޻<sSQ8޻5<sSQ8޻<sSQ9AoKGZĊ]@^/޻5<sSQ8޻5<sSQ8޻<sSQ8޻5<s~Vt/Cjy>s槚qw>jy>s⧚qw>*y>s⧚s)/VS=%Cee3cȘDN,Ҫ<7TwFK#FA>Qs "&Z{Ū;#i%ѣj Ioz=>xLG$絍dmWxU]Qt(Ӫ6IFhM@kwQUx'aiKMeJ$VK#"sLOIcdG 2sc/0t| hH~4Ww}uLs:jvj2ihZwSHWEmf퍪5=ĈE1c(u4K$ʭjG Ʀ|}S;Q8 b$Фs#m^~M:;k1MGpe6:&r1nS =`̒9%}UDPVXfDWq#MhR25tuVd| )]82Y^zF>J5REr2^6 3e@z#DӺFI"92$EvlWm21HZ0TӘ{csnѪftrI#hruKfZnR6VȈDTD2 }wmSTX٥G L5U&q&ӪBZ8܌ts.k#,4ɟ6&2+X$]ۜ6k/=m=\mthgc0S Bzh+W"+؈xx(eoB:g***#ti Tjjku 8sicj;I],qN(먍fHQpF梯e Yn}HoTax-{R-}KW[(jaXV4C?M[T]h+((?%kTPi[]CEh|=Ec)#p<Y+kWl7z&ڪɣ1br֦{]uWu͚H`^c=s\MժkMIt+ثir+㨉90D;Uny6 (繯ML:6&k[Ǔ2Ҿ Ѥ,j=rjpDVuv}m<09ZxTǦ|2('C,֊ ^r+rل\.N2_=jeG,5Zz&umY3UEpX2>U^-Yj"mMU2֪תЪѪyRL7ZW[JڥLu:=ѦIC=5m\j]jj2*:̘vp: +L1atdj9O N \{^oDINV67Gp.PҪk?Mcm_ϕ˼ <$T ũEF0$*)u{U1 [E Z͍NWIM%]Ń?OS{hZ`G>SjHM nq_+;T}ڥ3I6~2 HԱ:L.ZžBHWE]ڸePePePePePePePePePePePePePePePePePePePePePePePePePePePePePePePePePePePePePePePePePӪkk6l)-q9Jek4Lrj=SݨoMd}PXrU{Wɹ'Vk#F$.Xk{ãu8VG[;XQȜr[}yₕئe<4:uYUUtS n3j:\-sVIr`4B8["ٗ9_3m__RV^ɩY&EJm(ht-5|\JߡLΒ93;^).;!DVuU=JH_TU963aw\vO%,=al͑4^~M`֞RUT]]QS{5;X8kˆU&Fs ]ZY79$GKq&N%tcFE6]tN DZ]˜_YDej1Εu_i/umz.ndy]Nfk5z*1LTj*ܽΖjlCs]ZE+IW1ٳ=nw KM_MK4PH] ŕHn6&5Nɪ$^*N!fȣ#"쎖l<>:Y(fȣ##Y7)l[24m4학vV5v fȣ#"쎖l<>:Y(fȣ#"dōXehjz.3ݹ[TVhic}K)l˝"5ʞl<>:Y(fȣ#"쎖l<>:Y(~-sfƔf]Etjc:Y(f#"쎖l<>yaܥ di:B̹t^՗X7,<>:Y(fȣ#"쎖l<>:Y(R5x)cDw+ŇvGK6E],y}wdtaQݑ͇GvGKE],y}wdKck꥖5{ H.ٝl<>:Y(f#"쎖l<>:Y(R5 RCt7r*y͇GvGK6E],y}wdtaQݑŇGvGK6E],y}wdnR76tbV;6=],y}wdtaQݑ͇GvGK6E],y}wdtaQݓ_KdOДB'˵HWK6E],y}wdtaQݑ͇GvGK6E],y}wdtaQݓoujuDlkW4\SodԪM=蜋 #\kx_5;5QG,"I$rwV~6ٞ<*4TP9TTELgzy$K-ds>4FֿYtZT\qQ|3(֪h\*Ke,9esIUj*&2Uʖn~_Kj;v+t 59˗Ck},΃v͉;W6ZOc綇\*m%e$n|z#ebkǢE_T>۹KhVIx}Փ#2W9^Dr+UWnN Ε1GzNh5xLi/v-CWL 葏ktddkXqLK=D , sG/ a4|$2V7 dsrTi"xh=ЪѪҪӪxn}&I]"f~11iV19|$:{] l5P%-LrST#Upz"x(d-ШkZGOc]vUlV-}$uzuTȈn]('Ԫkp"TZT EnY *^GQ_ElMplYNcDTTC^usto3\,.ʩ4::>BbOWɺ+tuRԭX[i\ԕkQ]ڪ <=]XڍMV21º71/S"mvTu8w-mHUƒ?A2tÚ+R[pj/:6DŦn3TLEW6TU.F&nV=IrYelzr#D] ZanֶȮ"ɩeD=ƵcXMWiKeJ[2kU*uo]"IzsWǗbwt7Hn F+#W+関jݢQ0ވ 5s䪎WO> Xۣ,OpDn8OJr^P۟Jآdҧ dʼg{i6zTrIXX1Q#EUEʪp! ݾodu|{j:ɇG1Eٍw-XﴉC7S&1Db&W; +vܬF" *+j}kW,cZe?;l7)a֮YO r~v>oS}\j}kW,cZe?;l7)a֮YO r~v>oS}\j}kW,cZe?;l7)a֮YO r~v>oS}\j}kW,cZe?;l7)a֮YO r~v>oS}\j}kW,cZe?;l7)a֮YO r~v>oS}\j}kW,cZe?;l7)a֮YO r~v>oS}\j}kW,cZe?;l7)a֮YO r~v>oS}\j}kW,cZe?;l7)a֮YO r~v>oS}\j}kW,cZe?;l7)a֮YO r~v>oS}\j}kW,cZe?;l7)a֮YO r~v>oS}\j}hj#ebTsvpLժ`nǪu\p-5E<ꬎxUhH{]8Qn!m r6ʚ/V1tSԫ٘ZJXYNUUWXUp܅֮*͆Yrث#l3'̰ǀwnf2W[uE;tUOGXծn2,WD{jQlbd]B/yxFBKE_pDj^KKƱ[\ܦQ+,(-ꎞ*4^I(x]SbO#X'Fn~?METع<ܝ‚;LSݟ@KSORS$#b$DTvQ2 [&: Ye1ʱCNĎx\V*EL2 -\XaEYO$U#{SanGWwbK+ MvaYqlMjd3VP>I6IȲY"5kڊ|vA-[C;@iȴݫq¼i˺5T֘eUM"M$"SM[I ))a{*"wez\K+Dڊ;fZ-$*7 kz.x8Ӏw%g`K5*)!:6ƫhUɳr;mT÷lpYTGO$)LkƹpmTUQ%,JHts1jr]^{mܖmMb@T%c5m4^.5LUO-$*X9jɅڈ'$ZԥOpiH}$:P9\1V(cw%g`iY5,RdZHUz#ÑQv"96mj#R"a)!VH1cQpDpYjFHtZjf6.؜Gkj2j#tzK*ĭ^ lկ=[nslqYPYY5zDn̢cSb -A5$*(kWb"nslif%Bt$:F7(ٌpvnslpYTꢤmc\{ڨ:n**=MT3;m8OV۹,;ZYm)PꤤXqsf1v-کo:Z*HR81rᩄڨMeΌI)!]\c[5rrX9v춘fRC2^ƪ.#S؜G7[-j)`ETTέmQ[ _5mꕭDUڊpvf$R(\3 j&\j0w%g`jOWI kdt .88kULSI +Ǣ1\90QPj""Róg8-Ե ZHuѢ7.Vvc-Mf۹,;]ޖ牪jbh"֪Z-x =dTTDʹsba6=[%=dH61Nr13eN5]]K*`s=StXע5kU] y.oϤ(\ʲ6&׻L'e u,M#iyX$biukt8v@h|;F8ڮr&\wةf#UbʈLQ0LnZ7Ej Ejp"MN-VKXv5;:SUёK.D3ZʚyXtRӽ񢱏ծ"*2 o7T:4湎~EOG"GL).;,ֲVQN5Z95z.Ure8C<\o* > {s`ڮkљw"m<_/MK[_FB Ndp:&QWXdبjz2 hd="ϝb7 -K Q5TώYE$֢pmf_4b^d{ΧN6;WM,mcKW(mEۓnmx|EGHr9Q3!ckl4Ս|eF.EWc;<ImHs\#̉r1\ɑx4-B9VjGRp]%9NѾ S*u#6Cؑ8V"&22EƧ50sUC \ȮketUV>=cܽ<Qt]LHK%GTsbj241[[K s窽r"eUUxHz(nQϔLihQxxܽJZV6ulziT 6DIf|RL{X,fjaGZEE&%t0@&c *w#\%G1u+yICZ؟#"G܋I+h&SIɕʩclt+;G$C>5D{$9jq~DdHQDLN"ΚΧoWf8{2ijs힮W#+%c:~8KaҭW:n9Ά46py-OTGMtcDDHvЪѪҪӪԪժ`WYmvV:8$)L{52gk{Ӷ~5Fڄ$mDRBhip;b֪j57wS3)yiVcn\cV99ڮ̰̊b٪)iE#Uz5rpWWE)&simYRDU̵ 5\F*ɓ+OmvwbVM$P2.\֮trw wK̵/TTY[p5Y.ʍtF.`R53z$q9ّ[jWiұlGUX>n5*SU9|I#s\]*)iinV.l]Y⣙J=2=殖Mmn*kf*5TVWgT$;F=W$tuNW]CXZFǸNX੕:%Ϛ6=UU\gpd+iWrweeELY,,$|sG3Q Ĕ5ܒkj7VkdJJN{cWlΊ+Q<<ӺTdAжU@cGLDTLl]OnksmDP,q2wR*&*]Nj_2LX- ZdM".f6^ol:N-:봴83K=7j!v9q-,,>5l=[1pʧqpdMDlY'nL{l3EUF&6a0-mLViT^ȼnFjÌ7 Us#r5UdI.ܕSWk\ΥUلl=T4m~꧆Y$mctI囫rj#[""p]TGX 䇡(SXb>UHi&) [SFC*ӢjG";f~E U|1\S5{=MC1Krl9ؔ5zMMhʚՉ$ ^K(sr÷Ѫ3IWs>V;f8TZhdITGׅSSo|O9N8UG+kr8N|rBUtTEkvqV@굮uT[4 %LNktDriU{)mK鑨+v&3ҪӪԪժ endstream endobj 2288 0 obj <>stream endstream endobj 2221 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\210\013\n)-10(\026)11(\025\002\020 \002\220\006\n\013 \222\013\r\025\002\025\026)11(\013 \006\220\202)10(\024\025\r\220\201\001\025\203 \n\220\n\220 \215\022\221\013\227\220\016\ \001\026)11(\025\r )]TJ 0 -1 TD [(\006\022\220\201\220\025\221\013\026\220\017\016\006\n\220\024 \024\016\202\ )10.1(\013\n)10(\025\007\025\001/\024\016\202)10(\013\002\016\n)-9.9(\026)-20(\215\024)]TJ 33.279 1 Td [(Risk factor)20(s of sigmoid v)10(olv)10(ulus in patients with idiopathic megacolon)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf -0.041 Tw 10 0 0 10 42.5197 542.1599 Tm [(\r\030\036\n\036\027\017 )0.5(\021\030\026\027\017\021\026 )0.6(\023\024)]TJ /Span<>> BDC ( )Tj EMC 8.729 0 Td [(\240\025\230, )0.5(\030\036\031\035\034\021\026\021\026\b )0.5(\007\036\235\036\022\024\020\030\026\235\017\017 )]TJ 0.056 Tw -8.729 -1.218 Td (\017)Tj /Span<>> BDC ( )Tj EMC 0.806 0 Td [(\023\024\022\026\026\021\036\035\016\b )0.6(\030\036\036\030\r\031\026\030\027\024\005 )0.5(\235\031\027\022\006\017\017 )0.6(\023\030\016\n\024\005 )0.5(\022\017\001\022\017 )]TJ -0.016 Tw -0.806 -1.218 Td (\(\230\026\002\035.)Tj /Span<>> BDC ( )Tj EMC (6\). \213\007\017\027\f\021\r\036\027\027\t\005 \023\026\030\026\n\036\021\ \030 \017\f\f\035\036\007\024\r\026\027\017\016 \023\026\f)Tj 0 Tw (-)Tj -0.057 Tw 0 -1.218 TD (\f\026\032\026 \023\024)Tj /Span<>> BDC ( )Tj EMC (\240\025\230, \020\007\036 \030\026\027\017\006\026 \002\t\035\026 \026\ \n\036\021\027\026)Tj /Span<>> BDC ( )Tj EMC (\227 \220\021\024 \004\026\f\021\024\021\026 )Tj -0.022 Tw T* (\007\017\f\021\026\035\034\027\024\005 \026\007\036\030\032\022\017 \022\ \024\027\021\030\026\f\021\026, \022\024\021\024\030\026\016 \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r )Tj 0.181 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC 0.85 0 Td [(\026\r\024\030\024\021\026\n\017 )0.5(\002\t\035\026 )0.6(\f\021\026\021\017\f\021\017\004\036\f\022\017 )0.6(\027\026\004\017\n\024 )0.5(\n\036\027\034\001\036. )]TJ -0.01 Tw -0.85 -1.218 Td (\230\026\022, \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\027\026\035\017\004\017\017 \026\r\024\030\024\021\026 \007\017\f\021\026\ \035\034\027\026\016 \026\007\036\030\032\022\026 \017\n\036)Tj 0 Tw (-)Tj 0.003 Tw T* (\035\026 \n\036\f\021\024 \r\f\036\020\024 \r)Tj /Span<>> BDC ( )Tj EMC (1)Tj /Span<>> BDC ( )Tj EMC (\(3,0%\) \027\026\002\035\033\007\036\027\017\017, \r)Tj /Span<>> BDC ( )Tj EMC (\021\024 \r\030\036\n\016 \022\026\022 )Tj -0.032 Tw T* (\031)Tj /Span<>> BDC ( )Tj EMC [(\023\026\006\017\036\027\021\024\r )0.5(\002\036 )0.5(\026\r\024\030\024\021\026 \024\027\026 )0.5(\002\t\035\026 \026\030\036\020\017\f\021\030\017\030\024\r\026\027\026\ )]TJ 0 Tw T* (\002\024\035\036\036, \004\036\n \r)Tj /Span<>> BDC ( )Tj EMC (\023\024\035\024\r\017\027\036 \f\035\031\004\026\036\r \(\230\026\002\035\ .)Tj /Span<>> BDC ( )Tj EMC (7\).)Tj 0.82 Tw T* (\215\030\017\027\026\022\017, \023\030\024\007\036\n\024\027\f\021\030\017\ \030\024\r\026\r\001\017\036 \f\021\026\021\017\f\021\017\004\036\f\022\017\ )Tj 0.247 Tw T* (\027\026\004\017\n\031\033 \026\f\f\024\006\017\026\006\017\033 \f)Tj /Span<>> BDC ( )Tj EMC (\004\026\f\021\024\021\024\005 \026\r\024\030\024\021\024\r, \002\t\035\ \017 )Tj 0.186 Tw T* (\r\022\035\033\004\036\027\t \r)Tj /Span<>> BDC ( )Tj EMC (\n\027\024\020\024\235\026\022\021\024\030\027\t\005 \026\027\026\035\017\ , \r\t\023\024\035\027\036\027\027\t\005 )Tj -0.022 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\023\024\n\024\013\034\033 \031\030\026\r\027\036\027\017\005 \n\027\024\ \032\036\f\021\r\036\027\027\024\005 \035\024\020\017\f\021\017\004\036\f\ \022\024\005 )Tj 0.168 Tw T* (\030\036\020\030\036\f\f\017\017, \020\007\036 \026\r\017\f\017\n\024\005\ \016\r\035\016\035\026\f\034 \002\017\027\026\030\027\026\016 \023\036\030\ \036)Tj 0 Tw (-)Tj T* (\n\036\027\027\026\016 \253\030\026\r\017\021\017\036 \026\r\024\030\024\ \021\026\273.)Tj 0.016 Tw T* (\203\026\017\035\031\004\001\017\036 \b\026\030\026\022\021\036\030\017\f\ \021\017\022\017, \f)Tj /Span<>> BDC ( )Tj EMC (\021\024\004\022\017 \030\036\027\017\016 \f\021\026\021\017\f\021\017)Tj 0 Tw (-)Tj 0.132 Tw T* (\004\036\f\022\024\005 \027\026\004\017\n\024\f\021\017 \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\020\027\024\f\021\017\004\036\f\022\024\005 \f\023\024\f\024\ \002\027\024\f\021\017, )Tj 0.042 Tw T* (\024\022\026\026\035\017\f\034 \031)Tj /Span<>> BDC ( )Tj EMC (\n\024\007\036\035\017, \r)Tj /Span<>> BDC ( )Tj EMC [(\022\024\021\024\030\031\033 \002\t\035\017 \r\022\035\033\004\036\027\t\ )0.5(\021\024\035\034)]TJ 0 Tw (-)Tj -0.016 Tw T* (\022\024 \030\026\n\036\030\t \022\017\001\024\022 \023\024)Tj /Span<>> BDC ( )Tj EMC (\007\026\027\027\t\n \017\030\030\017\020\024\f\022\024\023\017\017)Tj /Span<>> BDC ( )Tj EMC (\227 \007\035\017\027\026 )Tj 0.337 Tw 23.244 23.138 Td (\017)Tj /Span<>> BDC ( )Tj EMC (\001\017\030\017\027\026 \f\017\020\n\024\r\017\007\027\024\005 \022\017\ \001\022\017, \017)Tj /Span<>> BDC ( )Tj EMC (\001\017\030\017\027\026 \023\030\016\n\024\005 )Tj 0.078 Tw T* (\022\017\001\022\017. \212\035\016 \220\021\024\005 \n\024\007\036\035\017\ \007\036\035\034\021\026 \221\024\n\036\030\f\026 \002\t\035\026 \030\026\ \r\027\026 )Tj 0.107 Tw T* (0,867, \026)Tj /Span<>> BDC ( )Tj EMC (\f\021\026\021\017\f\021\017\022\026 \025\024\035\n\024\020\024\030\024\r\ \026-\221\n\017\030\027\024\r\026)Tj /Span<>> BDC ( )Tj EMC (\227 0,718, )Tj 0 Tw T* (\023\030\017)Tj /Span<>> BDC ( )Tj EMC /T1_2 1 Tf 1.742 0 Td (p)Tj /T1_1 1 Tf -0.012 Tw /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (0,0001, \004\021\024 \020\024\r\024\030\017\021 \024)Tj /Span<>> BDC ( )Tj EMC (\b\024\030\024\001\036\005 \022\035\026\f\f\017\235\017\022\026\006\017)Tj 0 Tw (-)Tj 0.095 Tw -1.742 -1.218 Td (\024\027\027\024\005 \f\023\024\f\024\002\027\024\f\021\017 \n\024\007\036\ \035\017. \215\030\017)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\n \f\021\026\021\017\f\021\017\004\036\f\022\017 )Tj 0.397 Tw T* (\027\026\004\017\n\t\n\017 \027\036\026\r\017\f\017\n\t\n\017 \023\036\ \030\036\n\036\027\027\t\n\017 \016\r\035\016\035\017\f\034 )Tj -0.005 Tw T* (\021\024\035\034\022\024 \001\017\030\017\027\026 \f\017\020\n\024\r\017\ \007\027\024\005 \022\017\001\022\017 \017)Tj /Span<>> BDC ( )Tj EMC (\001\017\030\017\027\026 \023\030\016\n\024\005 )Tj 0.052 Tw T* (\022\017\001\022\017. \210\021\027\024\001\036\027\017\036 \001\026\027\f\ \024\r \007\035\016 \001\017\030\017\027\t \023\030\016\n\024\005 \022\017\ \001)Tj 0 Tw (-)Tj 0.005 Tw T* (\022\017 \f\024\f\021\026\r\017\035\024 0,39 \(\212\222 0,22\2260,72\), \ \007\035\016 \001\017\030\017\027\t \f\017\020\n\024)Tj 0 Tw (-)Tj T* (\r\017\007\027\024\005 \022\017\001\022\017)Tj /Span<>> BDC ( )Tj EMC (\227 2,29 \(\212\222 1,38\2263,82\) \(\230\026\002\035.)Tj /Span<>> BDC ( )Tj EMC (8\).)Tj 0.348 Tw T* (\203\026 \030\017\f\031\027\022\036 1 \023\030\036\007\f\021\026\r\035\036\ \027\026 ROC-\022\030\017\r\026\016 \007\035\016 \220\021\024\005 )Tj 0.206 Tw T* (\235\031\027\022\006\017\017. \221\024\020\035\026\f\027\024 ROC-\026\027\ \026\035\017\031, \023\035\024\013\026\007\034 \023\024\007 \022\030\017\ )Tj 0 Tw (-)Tj 0.164 Tw T* [(\r\024\005 \f\024\f\021\026\r\017\035\026 )0.5(0,93)]TJ /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (0,03 \(\212\222 0,87\2261,0\), )Tj /T1_2 1 Tf 0 Tw (p)Tj /T1_1 1 Tf 0.164 Tw /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (0,001. )Tj 0.127 Tw T* (\025\030\017\021\036\030\017\036\n \236\007\036\027\026 \002\t\035\026 \024\ \023\030\036\007\036\035\036\027\026 \024\021\030\036\027\026\016 \021\024\ \004\022\026, )Tj 0.111 Tw T* (\030\026\r\027\026\016 0,719, \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\022\024\021\024\030\024\005 \004\031\r\f\021\r\017\021\036\035\034\027\024\ \f\021\034 \n\024\007\036\035\017 )Tj 0 Tw T* (\f\024\f\021\026\r\017\035\026 82,4%, \026)Tj /Span<>> BDC ( )Tj EMC (\f\023\036\006\017\235\017\004\027\024\f\021\034)Tj /Span<>> BDC ( )Tj EMC (\227 89,5%.)Tj 0.496 Tw T* [(\215\024 )0.5(\007\026\027\027\024\005 )0.6(\n\024\007\036\035\017 )0.5(\002\t\035\026 )0.6(\023\024\f\021\030\024\036\027\026 )0.5(\027\024\n\024\020\030\026\n\n\026 )]TJ 0.102 Tw T* [(\023\030\024\020\027\024\017\030\024\r\026\027\017\016 )0.5(\030\017\f\022\026 \026\r\024\030\024\021\026 \f\017\020\n\024\r\017\007\ \027\024\005 )0.5(\022\017\001)]TJ 0 Tw (-)Tj 0.192 Tw T* (\022\017 \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\017\007\017\024\023\026\021\017\004\036\f\022\017\n \n\036\020\026\022\024\ \035\024\027/\n\036\020\026)Tj 0 Tw (-)Tj 0.219 Tw T* (\030\036\022\021\031\n \023\024)Tj /Span<>> BDC ( )Tj EMC (\030\026\n\036\030\026\n \023\030\016\n\024\005 \017)Tj /Span<>> BDC ( )Tj EMC (\f\017\020\n\024\r\017\007\027\024\005 \022\017\001\024\022 )Tj 0 Tw T* (\(\217\017\f.)Tj /Span<>> BDC ( )Tj EMC (2\).)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 275.0305 262.0659 Tm [(\037\036)10(\032\223\212\226\034\022\031\034)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0 Tc 0.051 Tw 10 0 0 10 274.9606 237.7099 Tm [(\221\030\036\007\017 )0.5(\235\026\022\021\024\030\024\r, )0.6(\023\030\036\007\030\026\f\023\024\035\026\020\026\033\013\017\b )0.5(\022)]TJ /Span<>> BDC ( )Tj EMC 16.628 0 Td [(\030\026\r\017\021\017\033 )0.6(\026)]TJ 0 Tw (-)Tj 0.002 Tw -16.628 -1.218 Td (\r\024\030\024\021\026, \004\026\013\036 \r\f\036\020\024 \r)Tj /Span<>> BDC ( )Tj EMC (\035\017\021\036\030\026\021\031\030\036 \031\023\024\n\017\027\026\033\021\ \f\016 \b\030\024\027\017)Tj 0 Tw (-)Tj 0.075 Tw T* (\004\036\f\022\017\036 \026\023\024\030\t, \004\026\f\021\024\036 \017\f\ \023\024\035\034\024\r\026\027\017\036 \f\035\026\002\017\021\036\035\034\ \027\t\b, )Tj 0.344 Tw T* (\r\t\f\024\022\024\001\035\026\022\024\r\026\016 \007\017\036\021\026, \004\ \021\024 \b\026\030\026\022\021\036\030\027\024 \007\035\016 \021\026\022\ \017\b )Tj 0.254 Tw T* (\253\220\027\007\036\n\017\004\027\t\b\273 \023\024)Tj /Span<>> BDC ( )Tj EMC (\026\r\024\030\024\021\026\n \030\026\005\024\027\024\r, \022\026\022 \202\ \235\030\017\022\026, )Tj -0.032 Tw T* (\221\030\036\007\027\016\016 \202\017\016 \017)Tj /Span<>> BDC ( )Tj EMC (\222\027\007\017\016, \023\024\032\017\035\024\005 \017)Tj /Span<>> BDC ( )Tj EMC [(\f\021\026\030\004\036\f\022\017\005 )0.5(\r\024\030\026\f\021 )]TJ -0.063 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\003\026\023\026\007\027\t\b \f\021\030\026\027\026\b, \024\f\024\002\036\ \027\027\024 \r)Tj /Span<>> BDC ( )Tj EMC (\f\024\004\036\021\026\027\017\017 \f)Tj /Span<>> BDC ( )Tj EMC (\f\026\b\026\030\027\t\n )Tj 0.074 Tw T* (\007\017\026\002\036\021\024\n \017)Tj /Span<>> BDC ( )Tj EMC (\027\036\005\030\024\023\f\017\b\017\026\021\030\017\004\036\f\022\017\n\ \017 \026\002\024\035\036\r\026\027\017\016\n\017, )Tj 0.272 Tw T* (\023\024\021\036\027\006\017\026\035\034\027\024 \r\036\007\031\013\017\n\ \017 \022)Tj /Span<>> BDC ( )Tj EMC (\027\026\030\031\001\036\027\017\033 \026\r\021\024\027\024\n\027\024\005\ )Tj 0.042 Tw T* (\017\027\027\036\030\r\026\006\017\017 \017)Tj /Span<>> BDC ( )Tj EMC [(\024\020\030\026\027\017\004\036\027\017\033 )0.5(\023\024\007\r\017\032\027\024\f\021\017 \023\026\006\017\036\027\021\024\ \r, )]TJ 0.149 Tw T* (\026)Tj /Span<>> BDC ( )Tj EMC 0.844 0 Td [(\021\026\022\032\036 )0.5(\026\027\026\021\024\n\017\004\036\f\022\017\036 )0.5(\024\f\024\002\036\027\027\024\f\021\017 )0.6(\021\024\035\f\021\024\005 )0.5(\022\017\001\022\017 )]TJ 0.015 Tw -0.844 -1.218 Td ([10,19]. \025)Tj /Span<>> BDC ( )Tj EMC (\023\024\f\035\036\007\027\017\n \024\002\t\004\027\024 \024\021\027\024\ \f\016\021 \031\007\035\017\027\036\027\017\036 \f\017\020)Tj 0 Tw (-)Tj -0.058 Tw T* (\n\024\r\017\007\027\024\005 \022\017\001\022\017 \r)Tj /Span<>> BDC ( )Tj EMC (\f\024\004\036\021\026\027\017\017 \f)Tj /Span<>> BDC ( )Tj EMC (\f\031\032\036\027\027\t\n \024\f\027\024\r\026\027\017\036\n )Tj 0.128 Tw T* (\036\036 \002\030\t\032\036\005\022\017, \026)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\032\036 \n\036\020\026\022\024\035\024\027 [2,20]. \025\024\ \f\r\036\027\027\t\n )Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 0.026 Tw 9 0 0 9 42.5197 730.483 Tm [(\020\004\206\f\t\204\004 )0.5(7.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf [( )0.5(\212\031\016\205\023\022\024\026\024\020 )0.5(\030\025\026\202\021\n\t\024\025\006\031\t\013\025\004 )0.5(\024\031\t\024\n\027)]TJ /Span<>> BDC ( )Tj EMC 21.304 0 Td [(\227 \t\032\026\027\021\031\021\025\031 )0.6(\033\n)]TJ /Span<>> BDC ( )Tj EMC 6.966 0 Td [(\005\025\021\026\032\021\020\003 \033\032\025\016\021\026\013\026\003 )0.5(\(\030\027\205\t\024\n\032\n\021\021\025\017 \024\n\006\021\020\017 )0.5(\013\032\025\024\031)]TJ 0 Tw (-)Tj -28.27 -1.2 Td (\032\025\017 \225\025\001\031\032\026\))Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 0 -1.2 TD [(T)48(able 7)124(.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf [( R)21(esults of diagnostic tests: binar)-42.6(y features \(tw)12.1(o-tailed Fisher e)-14.9(x)10(act test\))]TJ ET 0 0 0 1 K 0.5 w /GS2 gs q 1 0 0 1 42.5197 704.381 cm 0 0 m 232 0 l S Q q 1 0 0 1 42.7697 683.5618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 274.5197 704.381 cm 0 0 m 89.5 0 l S Q q 1 0 0 1 274.5197 683.5618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 364.0197 704.381 cm 0 0 m 83.15 0 l S Q q 1 0 0 1 364.0197 683.5618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 447.1697 704.381 cm 0 0 m 48.9 0 l S Q q 1 0 0 1 447.1697 683.5618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 495.8197 683.5618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 42.5197 683.3118 cm 0 0 m 232 0 l S Q q 1 0 0 1 42.7697 672.0926 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 274.5197 683.3118 cm 0 0 m 89.5 0 l S Q q 1 0 0 1 274.5197 672.0926 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 364.0197 683.3118 cm 0 0 m 83.15 0 l S Q q 1 0 0 1 364.0197 672.0926 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 447.1697 683.3118 cm 0 0 m 48.9 0 l S Q q 1 0 0 1 447.1697 672.0926 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 495.8197 672.0926 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 42.5197 671.8426 cm 0 0 m 232 0 l S Q q 1 0 0 1 274.5197 671.8426 cm 0 0 m 89.5 0 l S Q q 1 0 0 1 364.0197 671.8426 cm 0 0 m 83.15 0 l S Q q 1 0 0 1 447.1697 671.8426 cm 0 0 m 48.9 0 l S Q q 43.02 683.562 231.25 20.569 re W n /GS0 gs q 1 0 0 1 43.0197 704.131 cm 0 0 m 231.25 -20.569 l S Q Q BT /GS1 gs /T1_4 1 Tf 8 0 0 8 243.8453 695.7465 Tm (\033\004\002\006\002\003)Tj -24.78 -1.2 Td (\200\006\t\213\b\004\220)Tj 33.7 0.6 Td (\240\004)Tj 10.578 0 Td (\b\r\003)Tj /T1_5 1 Tf 8.698 0.001 Td (p)Tj /T1_1 1 Tf -52.977 -2.034 Td (\212\017\f\021\026\035\034\027\026\016)Tj /T1_4 1 Tf ( )Tj /T1_1 1 Tf (\026\007\036\030\032\022\026)Tj /T1_4 1 Tf ( )Tj /T1_1 1 Tf (\022\024\027\021\030\026\f\021\026)Tj /T1_4 1 Tf ( )Tj /T1_1 1 Tf (\023\030\017)Tj /T1_4 1 Tf /Span<>> BDC ( )Tj EMC /T1_1 1 Tf (\017\f\f\035\036\007\024\r\026\027\017\017)Tj /T1_4 1 Tf ( )Tj /T1_1 1 Tf (\021\030\026\027\017\021\026)Tj /T1_4 1 Tf ( )Tj /T1_1 1 Tf (\023\024)Tj /T1_4 1 Tf /Span<>> BDC ( )Tj EMC /T1_1 1 Tf (\240\025\230)Tj /T1_4 1 Tf 32.249 0 Td (1)Tj /Span<>> BDC ( )Tj EMC (\(3,0%\))Tj 10.235 0 Td (22)Tj /Span<>> BDC ( )Tj EMC (\(53,7%\))Tj 9.492 0 Td (0,001)Tj 1 0.68 0 0.12 k /GS0 gs 9 0 0 9 42.5197 655.1233 Tm (\020\004\206\f\t\204\004 8.)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf [( \240\021\n\204\031\t\024\027\031\021\021\026\002 \023\n\202\025\t\024\025\ \006\031\t\013\026\002 \032\031\202\032\031\t\t\025\002 \033\032\n\202\021\ \n\016\025\032\n\027\026\021\025\002)0.5( \032\026\016\027\025\024\025\002 \016\026\027\n\032\n\024\026)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf T* [(T)48(able 8.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf [( Multiple logistic reg)14.2(ression of p)46.1(redicting of sigmoid v)13.2(olvulus)]TJ ET /GS2 gs q 1 0 0 1 42.5197 639.8214 cm 0 0 m 136.238 0 l S Q q 1 0 0 1 42.7697 628.3521 cm 0 0 m 0 11.219 l S Q q 1 0 0 1 178.7579 639.8214 cm 0 0 m 77.782 0 l S Q q 1 0 0 1 178.7579 628.3521 cm 0 0 m 0 11.219 l S Q q 1 0 0 1 256.5395 639.8214 cm 0 0 m 84.04 0 l S Q q 1 0 0 1 256.5395 628.6021 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 340.5793 639.8214 cm 0 0 m 84.04 0 l S Q q 1 0 0 1 424.6191 639.8214 cm 0 0 m 71.444 0 l S Q q 1 0 0 1 424.6191 628.6021 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 495.813 628.3521 cm 0 0 m 0 11.219 l S Q q 1 0 0 1 42.7697 617.1329 cm 0 0 m 0 11.219 l S Q q 1 0 0 1 178.7579 617.1329 cm 0 0 m 0 11.219 l S Q q 1 0 0 1 256.2895 628.3521 cm 0 0 m 84.29 0 l S Q q 1 0 0 1 256.5395 617.1329 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 340.5793 628.3521 cm 0 0 m 84.29 0 l S Q q 1 0 0 1 340.5793 617.1329 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 424.6191 617.1329 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 495.813 617.1329 cm 0 0 m 0 11.219 l S Q q 1 0 0 1 42.5197 616.8829 cm 0 0 m 136.238 0 l S Q q 1 0 0 1 42.7697 605.6716 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 178.7579 616.8829 cm 0 0 m 77.782 0 l S Q q 1 0 0 1 178.7579 605.6716 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 256.5395 616.8829 cm 0 0 m 84.04 0 l S Q q 1 0 0 1 256.5395 605.6716 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 340.5793 616.8829 cm 0 0 m 84.04 0 l S Q q 1 0 0 1 340.5793 605.6716 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 424.6191 616.8829 cm 0 0 m 71.444 0 l S Q q 1 0 0 1 424.6191 605.6716 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 495.813 605.6716 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 605.4216 cm 0 0 m 136.238 0 l S Q q 1 0 0 1 42.7697 594.2024 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 178.7579 605.4216 cm 0 0 m 77.782 0 l S Q q 1 0 0 1 178.7579 594.2024 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 256.5395 605.4216 cm 0 0 m 84.04 0 l S Q q 1 0 0 1 256.5395 594.2024 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 340.5793 605.4216 cm 0 0 m 84.04 0 l S Q q 1 0 0 1 340.5793 594.2024 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 424.6191 605.4216 cm 0 0 m 71.444 0 l S Q q 1 0 0 1 424.6191 594.2024 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 495.813 594.2024 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 42.5197 593.9524 cm 0 0 m 136.238 0 l S Q q 1 0 0 1 42.7697 582.7332 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 178.7579 593.9524 cm 0 0 m 77.782 0 l S Q q 1 0 0 1 178.7579 582.7332 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 256.5395 593.9524 cm 0 0 m 84.04 0 l S Q q 1 0 0 1 256.5395 582.7332 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 340.5793 593.9524 cm 0 0 m 84.04 0 l S Q q 1 0 0 1 340.5793 582.7332 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 424.6191 593.9524 cm 0 0 m 71.444 0 l S Q q 1 0 0 1 424.6191 582.7332 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 495.813 582.7332 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 42.5197 582.4832 cm 0 0 m 136.238 0 l S Q q 1 0 0 1 42.7697 571.2719 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 178.7579 582.4832 cm 0 0 m 77.782 0 l S Q q 1 0 0 1 256.5395 582.4832 cm 0 0 m 84.04 0 l S Q q 1 0 0 1 340.5793 582.4832 cm 0 0 m 84.04 0 l S Q q 1 0 0 1 424.6191 582.4832 cm 0 0 m 71.444 0 l S Q q 1 0 0 1 495.813 571.2719 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 571.0219 cm 0 0 m 136.238 0 l S Q q 1 0 0 1 178.7579 571.0219 cm 0 0 m 77.782 0 l S Q q 1 0 0 1 256.5395 571.0219 cm 0 0 m 84.04 0 l S Q q 1 0 0 1 340.5793 571.0219 cm 0 0 m 84.04 0 l S Q q 1 0 0 1 424.6191 571.0219 cm 0 0 m 71.444 0 l S Q BT /GS1 gs /T1_4 1 Tf 8 0 0 8 96.024 625.4521 Tm (\200\006\t\213\b\004\220)Tj 14.473 0 Td (\017\016)Tj 9.371 0.717 Td (95% \031\002\r\006\t\003\r\f\001\b\013\005 \t\b\003\r\006\004\f)Tj /T1_5 1 Tf 21.42 -0.716 Td (p)Tj /T1_4 1 Tf -23.567 -0.717 Td (\025\t\202\b\235\235 \n\006\004\b\t\204\004)Tj 10.421 0 Td (\026\r\006\216\b\235\235 \n\006\004\b\t\204\004)Tj /T1_1 1 Tf -38.421 -1.433 Td (\212\035\017\027\026 \f\017\020\n\024\r\017\007\027\024\005 \022\017\001\ \022\017)Tj 20.663 0 Td (1,01)Tj 10.114 0 Td (0,94)Tj 10.505 0 Td (1,09)Tj 9.202 0 Td (0,7440)Tj -50.484 -1.433 Td (\234\017\030\017\027\026 \023\030\016\n\024\005 \022\017\001\022\017)Tj /T1_4 1 Tf 20.524 -0.001 Td (0,39)Tj /T1_1 1 Tf 10.253 0.001 Td (0,22)Tj 10.505 0 Td (0,72)Tj /T1_4 1 Tf 9.007 -0.001 Td (0,0023)Tj /T1_1 1 Tf -50.288 -1.433 Td (\234\017\030\017\027\026 \f\017\020\n\024\r\017\007\027\024\005 \022\017\ \001\022\017)Tj /T1_4 1 Tf 20.524 -0.001 Td (2,29)Tj /T1_1 1 Tf 10.253 0.001 Td (1,38)Tj 10.505 0 Td (3,82)Tj /T1_4 1 Tf 9.007 -0.001 Td (0,0014)Tj /T1_1 1 Tf -50.288 -1.433 Td (Somers\245 D)Tj /Span<>> BDC ( )Tj EMC (\227 0,867, KS statistic)Tj /Span<>> BDC ( )Tj EMC (\227 0,718, )Tj /T1_2 1 Tf (p)Tj /T1_1 1 Tf /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (0,0001)Tj ET q 42.52 122.57 221.102 166.003 re W n q /GS0 gs 221.1023475 0 0 166.1268521 42.5196833 122.4465678 cm /Im0 Do Q Q BT 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 10 0 0 10 263.622 122.5701 Tm ( )Tj 0.05 Tw 9 0 0 9 42.5197 111.7701 Tm (\022\t\217\210\b\002\220 1.)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf ( ROC-\013\032\025\027\026\002 \003\n\030\031\023\025 \033\032\n\202\021\n\ \016\026 \016\026\027\n\032\n\024\n\027 \t\025\202\003\n)Tj 0 Tw (-)Tj T* (\027\025\030\021\n\017 \013\025\001\013\025)Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 0.126 Tw T* [(F)-16(igure )0.5(1)47(.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf [( R)19(OC cur)-41.9(v)13(e of the )0.5(sigmoid colon )0.5(v)13(olvulus )0.5(p)45.9(rediction )]TJ 0 Tw T* (model)Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\033\030\031\030\213\b)-20.9(\035\231\213\233\t \021\032)50(\b)42(\032\231\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj /T1_6 1 Tf 25 0 0 25 512.8768 56.0378 Tm (37)Tj ET endstream endobj 2222 0 obj <>stream Adobed     '$''''$25552;;;;;;;;;;   ####''',,,   ####''',,,   ####''',,,[""  u!1"AQRa2Tq#$ %&'()*3456789:BCDEFGHIJSUVWXYZbcdefghijrstuvwxyz !1AQa"Cbq2Sr #$%&'()*3456789:BDEFGHIJRTUVWXYZcdefghijstuvwxyz?DT$tD.D@tD.D@tD.D@tD.D@tD.D@tD.DJK+[,-Yl5\ȄLnkCFbs}2P"7 TjiktcCIg^g>k/ VܺPh-C9B6m,W)(ic=4ZcT85ohx9NSvJ*+G]jS6x$9f1cm [[UL.T 5)d15᱐1Ａ&{9]xAO8i)hS7vTpzINVTQ#05KE7Ṻx.ﮗ],ݴF* e1xb# &4me4TsQv3FփK2z =1աĥˤlBӔnީV]jzJ,W+iPiw7K(.D@tD.D@tD.D@tD.D@tD.D@tD.D@됸\+дP0D@DDD@DDD@DDWœ`ֹ-(cD,wY־f1ө[^0IqI)ZR#E{(\G<8F, 3,nsDZ W5zӴ6XCt!͊푂V&s֍ZouiQ3}y$*5:ucNIIuNTnU}y=1QBݸi4Ѧŭ*RTnW5iyjzkiXѤڔ\%$袸IZNZM=5 %3Mc2["!2eM^5vk/sV,%#Uw:WH3 uh.Ѧ25},M%Qݱk@؉;%BNwIO>'OiuM,JV\E$ZZޱ%ĎjUҗVW"qXZ*NRZލԴQRVRmW Œt1@lqa :o_:3a`|-kc [h!f22C\ԃe5:2)0aMi'>* k[oKTi<=.W~%G-4ЭRtZ9GTIړMJ[6׳!#n9|ċ竝vJ$a^|h=cgJZN8WaV8DE" """ """ .BrCѴP08HZ.b;.vD9^Hp<+amvkCEɢGu̔:1\ e*j_^}"(E6V&賢l- Zg*:5UJ֘q:qWeDNu\pXcetCM™13qCF(tz{|HbsnMm #ӻ$ 4ܖSDtHrt8mIJ.I)YxU&{΋u޵]=ONZm'&ڌV 6iogcO䴺DS^FKyLgrBaYzMS:'YgB$O7vOLx7ktϿN|uv6˪8Xm'kT i39!A0quC]6#gBu3oYBݮ%> ]?3ґ5ΟJ&4UOZci;\.HPsL=1i i3e57L[ĝf x:x7ktϿGvOLZci;\vuL\zc8ӒLglϜDocs YfʟYgB$Y]K&}<Dgߤ>5hazi'5uPVW)Zci;\.HPsL=1i i3e57L[Ģ)i 16%*Ξ ]?3ݮ%>9ֱN.ZְkMMgn]Rzc8ӒLgJVXր쓬u3oYBݮ%> ]?3ӜfMZ}+rmmw:;I1rBa\BaY:MS:./d9L0 p|o`k\ +CF8ƴ$JpmçvOLx7ktϿN|uv6˪_GֆN}&ݕ8i.j Yzc8ӒLg2}qx"š׾cTT/k5BF,EƎ*,F *n} ~w.ώvuGkr4Ɯzc8^Sy΅K FKi&ؚ$ax- E7{JvOLx7ktϿN|uv6˪K5^JkDSHPsL=1i i3sOEM w n%Ĺēsif-c9-$4[dlB *n} ~w.ώvuGkrꙹ!A0q$(95|C<ڳmImŶ زM e501NMX%wv^çvOLx7ktϿN|uv6˪_OZƗIvINVdҵ6蓢Uw"\zc8 ]?3ґ5ΟJ*:i$twުc]SHPsL=1i i3)m%3ְ<؞60FV;ٮksC9<) N.ǣptn} ~w.ώvuGkr9!A0q$(95LA$4$ac thgd'Q>OZ[6kfQb7p݇FVtn} ~w.MZE iM4N˜{7~,qֱN.$(95$(95>Nakc.8&BmSmY]K&}<Dgߧ>:;I%̔SZi'n{LgrBaP&RUG۩ZqcF>Euz5Lk "tK:L>V_]K&}<Dgߧ>:;Iuv6˪9!A0q$(95A4/i ,y˲5 zY-kl2V̨tn} ~w. Z=44ӷFq&ը5%Tc]S'$(944ƕ92k ,v6>;1un-FdSuQk-s]Hu\u#Eusj*Ξ ]?3ݮ%>9ֱN.c]Q i39!A0qSdz gbG-^9).H]Uр F69-n؅ZmQWݮ%> ]?3ҋ\RqZ}*U%GL*}c]R|zc8ӒLguO06ehkӣ13YkBژQB)i3s;% 9 DmZ-rDZu]K&}<Dgߧ>:;Iuv6˪v,>7sHp;B]nF Q(]vWd(N6w2r)E' $% 8UUU;JNZ.&ܥߊe^ҴP0D@jdo/^|mjo/^|!דOk_[RF")D@Qo.IE$I]n_e=!|1֐tol..:MP kK H#1]5{<[Gj"]u`tB٢\XZK\ F8 M cEјWL+uqDDE񑾵w)(W}$""" ФЀ """ ""#m%co8) ",s 4fY#` ]`'@DtJyaf ]0M slT`ڇ-q9mC PF"nX+0)z;5{`Ecyv3gZ9".bȔ_Z9<8O1鵳j0Xp-aCȎ?Z>C&*/+[ֳ&7}2><ӴP0D@i@Ş̈́Xp-ūr(zAƫDq֮eQq7WL><-)#q" (wd9wvH" ܽU=>Rư8؇a]xՃ!M<9EU4z׹u͔~I <-51g)RDǟ<'MnI5ej=rΖKz֚Nž zIp%n,;;QwƘ8ԃGb;@^CP1=d4ΎfҸ{fF &,n\6pHy/Ә8b$r[4ՆqIik/Ůif(V3i7XNfk+uc cA7Z,܂.6ڍ7mF@[#A9p#[>1Da1`fZ40wn'FrxUmjekw a{a®+i2x#tֳ.-}O 6cH1=$gmujN{Ňf\O ]2>po 9{i2|u|m,lc'6k7͏,e7RuDӹdqCak퐷塥rB+p k - 6'5M45mk' v&bۂ&h> ,We}4U5C*eDwuFg4؜ʱBA 2hc-`Tq]*\idGb;P񑾵w&#=N5kNmoo"(;LGpzh(;LGpzh(;LGpzh(;LGpzh[7Bb;Q{Ȋ88$88$88$88$88*(p.8Xb;arTۢUo$*Xco8-i+#4Gf26 m2:ƎAa,#Tw`-nFCb-M5 k@+R0ƒ2kXWo"t@OF^gΞw :WӅX4s>l(;LGpzjueEGpziS@HS1qHS1qN t-* כ[U0GYӭd<;uմP0{+ck H9 r}XX27#k@ .@ %7Nk4Y鴒=,'rܭVcZP)أmss4"פ`[i`򃉕4k0. m]fR7ܺ$J:bx;a3cok_EOE(!etoUv'BiƘ0XaEjԐRj!yWh ukZZ5i*߮YM2 r^̀o69˹ZeGZêb.8\q܁|l]4'&J p]W0]DE̐ #wd]ݒ$""" |do] J'F` """ (@~t)(@~t H" "QU (%6dl8y6s,fWGE4n"<w8Xl(]jNv>+., O<8fq2gLmek,IKb}@~1cनHD@DD=/z:a7[iPد>n_3 JNZ[}.I]gXJW[|yCȎ?ZִP0D@jdRH~C֦EhnG sfZ D[i5OH!ܜm<Ӫ[$e@#4Y͎x1lv˴OH4myeU.EhxB86Ҫۖȝll><oE+'G1m8\|X`[$" (wd]ݒ$""" |do] J'F` """ (@~t)(@~t H"SW 6Hq3]#h_9X Ā &g$ZfZcΨx"!ͯ<)f8z[JK9:|Xo+p`VÖ|sH]0NL&pxn[`*9:VN@1pRQ6" . NU+~ vK3+k$fq`KXNmCb|2>OeP=he9i s~*u1+f|aCȎ?Z״P0\9cKCZI'0i%E$Zr1\$kepmdnɖp.3RM]F&r7EH>x՞)Xt=9 FȢeO[^N?Ғ27֮%#}j@D@DD_zٿ:_zٿ:%!9 El4gw ev$3i$ RKTD@Am36+~`[W#:Ҍ5I8}h% ;ihևg{ NдE I ʹ$KL9k)2`M$4sݧ8ϮNU*ff"(Q94QUw_)4ۢ>[\ZM_WK NjQ4:ƞ\Q^sVhғaes KZӀg. s\恳p dj8|RUS4P8ŪZE Mס)QSQ ͩz5NRҭnW;Mx֏8-9%FԕwyAf~&]`g9yÜ쁕AL4n -1\ͽ,F"cXM݄h%$*9B+(dUUGzuqvbtzGѧL!7)=h֞ġ85iN(][^N?Ғ5{[u}IرIpoYbʹUҲ*Jzy)hZ 9f~ݴT5Mgi4b7 Nh.j(*ML,q^ &KG*EUX]uokCRidx0g9F׶g )oM\5Lk`wH&+Ǩ8FA$ Zm=YPלKP8 l {ѳeV8dDbRxA5bpm9E-a-Er\꽦ڪW٬oVY0jXUF2&Xfh- V0H 휪52 <D@Q%%$D@DD#}jRQ>27֮IDD^F$ kE˜lWZ)L3<]0/bN`PG߫ R\-cXxoXsҴךO,f9a"Faы6'f΀G nW1.s@h9$yܙ e|z ZӇ Z4ܝpd;5ۙVZ:ҭRSܨˮX!U"ގmE"RJTS􈈪Ժ| NfO 8bcó-27֮IkV2j19ؙt4o7.NWB3d8 ֊]u Plm6sme{flidMsܹt{ c 8RU<{;2/{D 4԰Ҵ=ۧ$M 2"nNռ8DE[7B[7B$""" ~1cऀ" "" 0-д|lW@BG":@k'GYӭdӲ'[؀-ppqqm-*\j!a#Ys`7QQ6t9S}LG>'5&MniMwshn'Xp9'`(VYk\<<`s\ZAb2#%Émsk:ӏ':Z9c5rPe]+5 clQ& nѰ<+.G'жYͳsϖHԱ Rp/{'56ՕmRn:MSpuhζ5e$y.Msފb);hu=qIAq=kMcG RJXmlY<٢z'qz'q$$Q6D46D4Ip ;0 ;ElNLlN@[˻LlNQ l4dElNLlN@G==$Q6D46D4Ip ;0 ;X8zW1qs@f+QN םh9smmA&IY5sgڔdZ#tsY]B<1l$W`굕5Ko_6+~ [W#:QZl׃~-R9*WruI毢ևg{ NմP0D@u}5OqG&i0_ijd\"JIJ=

C>ӏ4ҵU7{t""" ]ݒywvH" 4Sen-kf3Mo(Ν{W0І**jgm^Y}89\ٶ$7M]y&Ev~]~Tc0oC)9hzrm;۫SִP0ZN421`hc]pNpcol4Lnia%8C@r.tszZ_G sQnנ餆UU%%U)ؕVNTΔv 훪FL#bi2d;>JɀH$`k rM3XE3E#bcH8\A:hUnxS>D<״P0k% AњW %Ս۪HakآTގJK]GFugNOG%Uhi谍-ZWyi at^5Ü;f_>L#ᩱ $Er(zAƫŪJ5zu4XKHpZ.ۍs~&Nrzt=my:ktJHDDD@b:6k@.{h`ukq'ZK_1=r3q|NِOE/3LtwFxvw9(:Uub"Þ=J=I4*m1y[1G@CրȢ9wvJ%7+K?]wP "" D@Q>27֮%#}j@D@DD_zٿ:_zٿ:$D@DDD@cणm$D@D\atRݦ_]~KV@3g*î`G":@k'>\FgBvuue%дP0D@u}S6K (doYjl$X$vO"7G';AWIIRx{t>CZW_tKf\YfVwȈEƌiɪֽ Ko;"` Kt=E\j>ᑴH4g=)+uu3 룅KFmNLΖgIbnp [ m(u}Ҳ"ǜXִց` HQ%%˻@D@DDOIDZ$D@DDo΅%o΄IDDD@co8)(yID@DD4>6+~`[iPد>n_3 ZDu:OCȎ?ZѴP0D@u}Uϒk[q27 M؝l.jdrG'0URTiG'MnIדOՆ*P$G36lX Tպ̟uS[7,pS=WTN`3 aCEfc"ÞxXqW1lS0N֨EoXfar%7-` RDU씔G.DDD@Q>27֮%#}j@D@DD_zٿ:_zٿ:$D@DDD@cणm$D@DDhdϔ$0Nz J t*d|ZRrմRKIʕZVց=UJ՚+ 4_55\>^Ӧ9ui'Wo&X}ez)h%jjc|MW,s=7Om=OE:MS$~K<r3t{N#iK]l-դϟ*e'66YuBMl28 d2EGe4:GX Rț8o=OE:MX0QkJ&]\uuغ-:VI)c;N9EQʕu_GmDƒZ$UVJQ i=W,s=7OggTR֖clcdFڻa}ez)h%'Wo&YlQvdV[SSUM:jc|[h}ez)h%'Wo&Y9tr3t{N-1CS$~KOE:M MW,s=7OgmZb[I8Y^u/gXzn/i ٕ҆\[c~浏 ͔+#KuBƵÉ9_=' )6Z+*[j`:'9I6`wȚt'[I]C~'(6$Rg]ku7 8kE{om쫢t>'qtqrJ-I8MUM:jc|\Ӕhb1L!Ŷ%$f[HM"[I8Y^u/gKS*e޷55\>^Ӧ9ui'Wo&X}ez)h%jjc|MW,s=7Om=OE:MS$~K<r3t{NXzn/i%({Y^u/c[IxgBWeCJIG\ 5Ƒt\trQ2C 5Xá8Z;Xn3l]8d> 4_<[&$Z4QxFTtΔӶ@TqnJm( [Jb'JFmW,s=7OgbWЙ1s0J_g܀X>+FtdSy}ez)h%'Wo&YZxh-z>'N5Ԗ )\ig55\>^Ӧ9ui'Wo&X}ez)h%i\ZC LҐƠ/¹r3t{N-1C#!IZ5Ii0'Wo&Y9tr3t{N-1CS$~KOE:M MW,s=7Ogm\) 2͊J3F9ۄg7t"mM:[I8Y^u/g %jJͅ+-ZQYuNFH]$4{Z&۬zXzn/i ΥɚŎk Ý c${H.^{4Szmrrn0zmF'.:UΊ8Y^u/gN+JT;tmFMXzn/iUM:D+NE,q> 4_55\>^Ӧ9ui'Wo&X}ez)h%jjc|MW,s=7Om=OE:MS$~K<r3t{NXzn/iyDBYZ$ǣemm%nP> 4_+NE,t:Y4rNcͥĨ`IRO{@vk/ml웄GFj-O 0`ֺ׋ iE[.'ѯn6I(jڷtrmtFsIxN;h4 MTM1RueE_MӴP0D@]&H6a^MlFd|Uc:9d3#t!vHە;.IlJvGean.KWֵ-=4OGg_27iŪ_YQֻ ""DDYO&A+95AQo,UϘDqj:5 AEhr;xP[ 'Ta861:+ҽ jR6U=$nX*ZqM16GI1S02μܕw֙A()7'+ZIjWT۱8D@]t!olnl0Ykɵ7b0=NvZkcc>)ecZ6: MvhGPGYQ=)wAN6pj""" ],he e[ѦM>^hNêUvە[_9xol87Nh]Er?(I ٖqԴP0D@DDD@DDD@DD䬊ń::ivmlR51an"'F44}o8M]Qitɵs=nYj#.F !ksg_f(TH  >stream endstream endobj 2220 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 0 0 0 1 k /GS1 gs /T1_0 1 Tf -0.009 Tw 10 0 0 10 70.8661 274.2439 Tm (\221\030\036\007\017 \023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC [(\026\r\024\030\024\021\024\n )0.5(\007\024\035\016 \n\031\032\004\017\027 )0.5(\024\022\026\026\035\026\f\034 )]TJ 0.023 Tw 0 -1.218 TD (\027\036\f\022\024\035\034\022\024 \n\036\027\034\001\036)Tj /Span<>> BDC ( )Tj EMC (\227 48,9% \017)Tj /Span<>> BDC ( )Tj EMC (58,7%, \f\024\024\021\r\036\021\f\021\r\036\027\027\024, )Tj 0.041 Tw T* (\027\024 \030\026\027\017\006\026 \002\t\035\026 \f\021\026\021\017\f\021\ \017\004\036\f\022\017 \027\036\027\026\004\017\n\026 \(\230\026\002\035\ .)Tj /Span<>> BDC ( )Tj EMC (4\). )Tj -0.022 Tw T* (\200)Tj /Span<>> BDC ( )Tj EMC [(\021\024\032\036 \r\030\036\n\016 \023\026\006\017\036\027\021\t )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC (\026\r\024\030\024\021\024\n \002\t\035\017 \007\024\f\021\024\r\036\030\ \027\024 )Tj 0.089 Tw T* (\f\021\026\030\001\036)Tj /Span<>> BDC ( )Tj EMC 3.24 0 Td [(\227 )0.5(\n\036\007\017\026\027\026 )0.6(\017\b )0.5(\r\024\030\026\f\021\026 )0.6(\f\024\f\021\026\r\017\035\026 )0.5(34,0 )0.5(\020\024\007\026, )]TJ 0.051 Tw -3.24 -1.218 Td (\021\024\020\007\026 \022\026\022 \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \002\036 \026\r\024\030\024\021\026 \220\021\024\ \021 \023\024\022\026\026\021\036\035\034 \002\t\035 )Tj 0 Tw T* (\030\026\r\036\027 21,0 \020\024\007\031, )Tj /T1_1 1 Tf (p)Tj /T1_0 1 Tf /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (0,0001 \(\230\026\002\035.)Tj /Span<>> BDC ( )Tj EMC (5\).)Tj 0.001 Tw T* (\203\036 \002\t\035\024 \r\t\016\r\035\036\027\024 \f\021\026\021\017\f\021\ \017\004\036\f\022\017 \027\026\004\017\n\t\b \030\026\035\017\004\017\ \005 )Tj -0.025 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\004\026\f\021\024\021\036 \b\030\024\027\017\004\036\f\022\017\b \026\023\ \024\030\024\r 81,8% \023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\026)Tj 0 Tw (-)Tj 0.183 Tw T* (\r\024\030\024\021\026\n\017 \017)Tj /Span<>> BDC ( )Tj EMC (90,8% \023\026\006\017\036\027\021\024\r \002\036 \027\017\b, \f\024\b\030\ \026\027\036\027\027\024\005 )Tj 0.173 Tw T* (\r\024\n\024\032\027\024\f\021\017 \f\026\n\024\f\021\024\016\021\036\035\ \034\027\024\005 \007\036\235\036\022\026\006\017\017, \r)Tj /Span<>> BDC ( )Tj EMC (\017\027\021\036\027)Tj 0 Tw (-)Tj 0.051 Tw T* (\f\017\r\027\024\f\021\017 \r\007\031\021\017\016 \032\017\r\024\021\026\ , \r)Tj /Span<>> BDC ( )Tj EMC (\r\t\030\026\032\036\027\027\024\f\021\017 \023\024\022\026\026\021\036\ )Tj 0 Tw (-)Tj 0.228 Tw T* (\035\016 \253\026\002\007\024\n\017\027\026\035\034\027\t\005 \007\017\f\ \022\024\n\235\024\030\021\273 \f\030\036\007\017 \023\026\006\017\036\027\ \021\024\r )Tj 0 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\026\r\024\030\024\021\026\n\017 \017)Tj /Span<>> BDC ( )Tj EMC (\002\036 \(\230\026\002\035.)Tj /Span<>> BDC ( )Tj EMC (4,5\).)Tj 0.009 Tw T* (\211 \023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\026\r\024\030\024\021\026\n\017 \004\026\f\021\024\021\026 \007\036\235\ \036\022\026\006\017\017 \002\036 \017\f)Tj 0 Tw (-)Tj 0.208 Tw T* [(\023\024\035\034\024\r\026\027\017\016 )0.6(\f\035\026\002\017\021\036\035\034\027\t\b )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 12.852 0 Td [(\022\035\017\n )0.5(\002\t\035\026 )0.5(\f\021\026\021\017\f\021\017)]TJ 0 Tw (-)Tj 0.172 Tw -12.852 -1.218 Td (\004\036\f\022\017 \027\026\004\017\n\024 \002\024\035\034\001\036, \026\ )Tj /Span<>> BDC ( )Tj EMC (\r\t\030\026\032\036\027\027\024\f\021\034 \023\024\022\026\026\021\036\ \035\016 )Tj 0.039 Tw 23.244 19.485 Td (\253\030\026\f\f\021\030\024\005\f\021\r\024 \007\036\235\036\022\026\006\ \017\017\273 \017)Tj /Span<>> BDC ( )Tj EMC (\017\027\021\036\027\f\017\r\027\024\f\021\034 \026\023\024\030\024\r )Tj 0.066 Tw T* (\023\024)Tj /Span<>> BDC ( )Tj EMC (\001\022\026\035\036 \200\036\022\f\027\036\030\026)Tj /Span<>> BDC ( )Tj EMC (\227 \007\024\f\021\024\r\036\030\027\024 \n\036\027\034\001\036 \(\230\026\ \002\035.)Tj /Span<>> BDC ( )Tj EMC (5\). )Tj 0.018 Tw T* (\223\026\f\021\024\021\026 \022\026\035\024\n\026\026\027\017\016 \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\026\r\024\030\024\021\026)Tj 0 Tw (-)Tj T* (\n\017 \021\026\022\032\036 \002\t\035\026 \f\031\013\036\f\021\r\036\027\ \027\024 \n\036\027\034\001\036 \(\230\026\002\035.)Tj /Span<>> BDC ( )Tj EMC (4\).)Tj 0.125 Tw T* (\204\036\007\017\026\027\026 \007\035\017\027\t \f\017\020\n\024\r\017\007\ \027\024\005 \022\017\001\022\017, \023\024)Tj /Span<>> BDC ( )Tj EMC (\007\026\027\027\t\n \017\030)Tj 0 Tw (-)Tj 0.112 Tw T* (\030\017\020\024\f\022\024\023\017\017, \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\026\r\024\030\024\021\026\n\017 \002\t\035\026 \f\021\026\021\017\f)Tj 0 Tw (-)Tj 0.17 Tw T* (\021\017\004\036\f\022\017 \027\026\004\017\n\024 \002\024\035\034\001\036\ , \004\036\n \002\036 \021\026\022\024\r\t\b \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\f\021\026)Tj 0 Tw (-)Tj 0.153 Tw T* (\r\017\035\026 80,0 \f\n \017)Tj /Span<>> BDC ( )Tj EMC (62,0 \f\n, \f\024\024\021\r\036\021\f\021\r\036\027\027\024 \()Tj /T1_1 1 Tf 0 Tw (p)Tj /T1_0 1 Tf 0.153 Tw /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (0,001\). )Tj 0.175 Tw T* (\234\017\030\017\027\026 \f\017\020\n\024\r\017\007\027\024\005 \022\017\ \001\022\017 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\027\026\035\017\004\017\017 \026\r\024\030\024\021\026 )Tj 0.05 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\026\027\026\n\027\036\036 \021\026\022\032\036 \002\t\035\026 \007\024\ \f\021\024\r\036\030\027\024 \002\024\035\034\001\036 \(\n\036\007\017\026\ \027)Tj 0 Tw (-)Tj 0.012 Tw T* (\027\t\036 \027\026\004\036\027\017\016 11,5 \f\n \023\030\024\021\017\r\ 9,0 \f\n, )Tj /T1_1 1 Tf 0 Tw (p)Tj /T1_0 1 Tf 0.012 Tw /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (0,0001\), \026)Tj /Span<>> BDC ( )Tj EMC (\r\024\021 )Tj 0.167 Tw T* (\001\017\030\017\027\026 \023\030\016\n\024\005 \022\017\001\022\017)Tj /Span<>> BDC ( )Tj EMC (\227 \027\026\023\030\024\021\017\r, \027\026\004\017\n\024 \n\036\027\034\ )Tj 0 Tw (-)Tj 0.136 Tw T* (\001\036 \(\n\036\007\017\026\027\t)Tj /Span<>> BDC ( )Tj EMC (\227 8,6 \f\n \023\030\024\021\017\r 10,5 \f\n, )Tj /T1_1 1 Tf 0 Tw (p)Tj /T1_0 1 Tf 0.136 Tw /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (0,0001\). )Tj 0.008 Tw T* (\221\031\013\036\f\021\r\036\027\027\t\b \030\026\035\017\004\017\005 \r\ )Tj /Span<>> BDC ( )Tj EMC (\001\017\030\017\027\036 \023\024\023\036\030\036\004\027\024\005 \017)Tj /Span<>> BDC ( )Tj EMC (\r\024\f)Tj 0 Tw (-)Tj -0.069 Tw T* (\b\024\007\016\013\036\005 \022\017\001\024\022 \n\036\032\007\031 \020\030\ \031\023\023\026\n\017 \024\002\027\026\030\031\032\036\027\024 \027\036\ \002\t\035\024. )Tj -0.003 Tw T* (\217\026\r\027\t\n \024\002\030\026\024\n, \023\026\006\017\036\027\021\ \t \f)Tj /Span<>> BDC ( )Tj EMC (\026\r\024\030\024\021\024\n \017)Tj /Span<>> BDC ( )Tj EMC (\002\036 \027\036 \023\030\024)Tj 0 Tw (-)Tj 0.363 Tw T* (\007\036\n\024\027\f\021\030\017\030\024\r\026\035\017 \007\024\f\021\024\ \r\036\030\027\t\b \030\026\035\017\004\017\005 \r)Tj /Span<>> BDC ( )Tj EMC (\024\002\013\036\n )Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0 Tw 9 0 0 9 70.8661 730.483 Tm (\020\004\206\f\t\204\004 4.)Tj 0 0 0 1 k /GS1 gs /T1_1 1 Tf ( \222\023\025\021\025\006\031\t\013\026\002 \013\026\032\024\025\021\026\ )Tj /Span<>> BDC ( )Tj EMC (\227 \t\032\026\027\021\031\021\025\031 \033\n)Tj /Span<>> BDC ( )Tj EMC (\005\025\021\026\032\021\020\003 \033\032\025\016\021\026\013\026\003 \(\ \030\027\205\t\024\n\032\n\021\021\025\017 \024\n\006\021\020\017 \013\032\ \025\024\031\032\025\017 \225\025\001\031\032\026\))Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0 -1.2 TD [(T)48(able 4.)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf ( Clinical picture)Tj /Span<>> BDC ( )Tj EMC [(\227 com)16.3(par)-37(ison by binar)-42.9(y signs \(tw)12.1(o-tailed Fisher e)-15(x)9.9(act test\))]TJ ET 0 0 0 1 K 0.5 w /GS2 gs q 1 0 0 1 70.8661 715.181 cm 0 0 m 227.022 0 l S Q q 1 0 0 1 71.1161 694.3618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 297.8878 715.181 cm 0 0 m 85.039 0 l S Q q 1 0 0 1 297.8878 694.3618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 382.9272 715.181 cm 0 0 m 85.039 0 l S Q q 1 0 0 1 382.9272 694.3618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 467.9666 715.181 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 467.9666 694.3618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 524.6594 694.3618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 70.8661 694.1118 cm 0 0 m 227.022 0 l S Q q 1 0 0 1 71.1161 682.9005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 297.8878 694.1118 cm 0 0 m 85.039 0 l S Q q 1 0 0 1 297.8878 682.9005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 382.9272 694.1118 cm 0 0 m 85.039 0 l S Q q 1 0 0 1 382.9272 682.9005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 467.9666 694.1118 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 467.9666 682.9005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 682.9005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 682.6505 cm 0 0 m 227.022 0 l S Q q 1 0 0 1 71.1161 671.4393 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 297.8878 682.6505 cm 0 0 m 85.039 0 l S Q q 1 0 0 1 297.8878 671.4393 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 382.9272 682.6505 cm 0 0 m 85.039 0 l S Q q 1 0 0 1 382.9272 671.4393 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 467.9666 682.6505 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 467.9666 671.4393 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 671.4393 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 671.1893 cm 0 0 m 227.022 0 l S Q q 1 0 0 1 71.1161 659.978 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 297.8878 671.1893 cm 0 0 m 85.039 0 l S Q q 1 0 0 1 297.8878 659.978 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 382.9272 671.1893 cm 0 0 m 85.039 0 l S Q q 1 0 0 1 382.9272 659.978 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 467.9666 671.1893 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 467.9666 659.978 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 659.978 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 659.728 cm 0 0 m 227.022 0 l S Q q 1 0 0 1 71.1161 648.5087 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 297.8878 659.728 cm 0 0 m 85.039 0 l S Q q 1 0 0 1 297.8878 648.5087 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 382.9272 659.728 cm 0 0 m 85.039 0 l S Q q 1 0 0 1 382.9272 648.5087 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 467.9666 659.728 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 467.9666 648.5087 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 524.6594 648.5087 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 70.8661 648.2587 cm 0 0 m 227.022 0 l S Q q 1 0 0 1 297.8878 648.2587 cm 0 0 m 85.039 0 l S Q q 1 0 0 1 382.9272 648.2587 cm 0 0 m 85.039 0 l S Q q 1 0 0 1 467.9666 648.2587 cm 0 0 m 56.943 0 l S Q q 71.366 694.362 226.272 20.57 re W n /GS0 gs q 1 0 0 1 71.3661 714.931 cm 0 0 m 226.272 -20.569 l S Q Q BT /GS1 gs /T1_2 1 Tf 8 0 0 8 267.2134 706.5464 Tm (\033\004\002\006\002\003)Tj -24.158 -1.2 Td (\200\006\t\213\b\004\220)Tj 32.799 0.6 Td (\240\004)Tj 10.417 0 Td (\b\r\003)Tj /T1_3 1 Tf 9.319 0.001 Td (p)Tj /T1_0 1 Tf -52.536 -2.033 Td (\215\024\035 \(\n\031\032\004\017\027\t\))Tj 31.099 0 Td (23)Tj /Span<>> BDC ( )Tj EMC (\(48,9%\))Tj 10.63 0 Td (61)Tj /Span<>> BDC ( )Tj EMC (\(58,7%\))Tj 10.224 0 Td (0,29)Tj -51.953 -1.433 Td (\003\026\023\024\030\t)Tj 31.099 0 Td (36)Tj /Span<>> BDC ( )Tj EMC (\(81,8%\))Tj 10.63 0 Td (89)Tj /Span<>> BDC ( )Tj EMC (\(90,8%\))Tj 10.224 0 Td (0,16)Tj -51.953 -1.433 Td (\203\026\035\017\004\017\036 \f\026\n\024\f\021\024\016\021\036\035\034\027\ \024\020\024 \f\021\031\035\026)Tj 31.099 0 Td (39)Tj /Span<>> BDC ( )Tj EMC (\(90,7%\))Tj 10.63 0 Td (72)Tj /Span<>> BDC ( )Tj EMC (\(80,0%\))Tj 10.224 0 Td (0,14)Tj -51.953 -1.433 Td (\025\026\035\024\n\026\026\027\017\036)Tj /T1_2 1 Tf 30.792 -0.001 Td (11)Tj /Span<>> BDC ( )Tj EMC (\(23,4%\))Tj 10.63 0 Td (49)Tj /Span<>> BDC ( )Tj EMC (\(49,5%\))Tj 10.113 0 Td (0,004)Tj 1 0.68 0 0.12 k /GS0 gs 9 0 0 9 70.8661 631.5395 Tm (\020\004\206\f\t\204\004 5.)Tj 0 0 0 1 k /GS1 gs /T1_1 1 Tf ( \222\023\025\021\025\006\031\t\013\026\002 \013\026\032\024\025\021\026\ )Tj /Span<>> BDC ( )Tj EMC (\227 \t\032\026\027\021\031\021\025\031 \033\n)Tj /Span<>> BDC ( )Tj EMC [(\013\n\023\025\006\031\t\024\027\031\021\021\020\003 \033)0.5(\032\025\016\021\026\013\026\003 \(U-\013\032\025\024\031\032\025\017 \240\ \026\021\021\026\226\214\025\024\021\025\))]TJ 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf T* [(T)48(able 5.)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf [( Clinical picture: q)14.2(uantitativ)13.1(e character)-36.9(istics \(Mann\226Whitney U-test\))]TJ ET /GS2 gs q 1 0 0 1 70.8661 616.2375 cm 0 0 m 181.667 0 l S Q q 1 0 0 1 71.1161 595.4183 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 252.5334 616.2375 cm 0 0 m 85.039 0 l S Q q 1 0 0 1 252.5334 595.4183 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 337.5728 616.2375 cm 0 0 m 85.039 0 l S Q q 1 0 0 1 337.5728 595.4183 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 422.6122 616.2375 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 422.6122 595.4183 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 467.9665 616.2375 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 467.9665 595.4183 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 524.6594 595.4183 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 70.8661 595.1683 cm 0 0 m 181.667 0 l S Q q 1 0 0 1 71.1161 583.949 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 252.5334 595.1683 cm 0 0 m 85.039 0 l S Q q 1 0 0 1 252.5334 583.949 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 337.5728 595.1683 cm 0 0 m 85.039 0 l S Q q 1 0 0 1 337.5728 583.949 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 422.6122 595.1683 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 422.6122 583.949 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 467.9665 595.1683 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 467.9665 583.949 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 524.6594 583.949 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 70.8661 583.699 cm 0 0 m 181.667 0 l S Q q 1 0 0 1 71.1161 572.4878 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 252.5334 583.699 cm 0 0 m 85.039 0 l S Q q 1 0 0 1 252.5334 572.4878 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 337.5728 583.699 cm 0 0 m 85.039 0 l S Q q 1 0 0 1 337.5728 572.4878 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 422.6122 583.699 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 422.6122 572.4878 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 467.9665 583.699 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 467.9665 572.4878 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 572.4878 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 572.2378 cm 0 0 m 181.667 0 l S Q q 1 0 0 1 71.1161 561.0265 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 252.5334 572.2378 cm 0 0 m 85.039 0 l S Q q 1 0 0 1 252.5334 561.0265 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 337.5728 572.2378 cm 0 0 m 85.039 0 l S Q q 1 0 0 1 337.5728 561.0265 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 422.6122 572.2378 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 422.6122 561.0265 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 467.9665 572.2378 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 467.9665 561.0265 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 561.0265 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 560.7765 cm 0 0 m 181.667 0 l S Q q 1 0 0 1 71.1161 549.5573 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 252.5334 560.7765 cm 0 0 m 85.039 0 l S Q q 1 0 0 1 252.5334 549.5573 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 337.5728 560.7765 cm 0 0 m 85.039 0 l S Q q 1 0 0 1 337.5728 549.5573 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 422.6122 560.7765 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 422.6122 549.5573 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 467.9665 560.7765 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 467.9665 549.5573 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 524.6594 549.5573 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 70.8661 549.3073 cm 0 0 m 181.667 0 l S Q q 1 0 0 1 71.1161 538.096 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 252.5334 549.3073 cm 0 0 m 85.039 0 l S Q q 1 0 0 1 252.5334 538.096 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 337.5728 549.3073 cm 0 0 m 85.039 0 l S Q q 1 0 0 1 337.5728 538.096 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 422.6122 549.3073 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 422.6122 538.096 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 467.9665 549.3073 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 467.9665 538.096 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 538.096 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 537.846 cm 0 0 m 181.667 0 l S Q q 1 0 0 1 71.1161 526.6347 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 252.5334 537.846 cm 0 0 m 85.039 0 l S Q q 1 0 0 1 252.5334 526.6347 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 337.5728 537.846 cm 0 0 m 85.039 0 l S Q q 1 0 0 1 337.5728 526.6347 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 422.6122 537.846 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 422.6122 526.6347 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 467.9665 537.846 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 467.9665 526.6347 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 526.6347 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 526.3847 cm 0 0 m 181.667 0 l S Q q 1 0 0 1 71.1161 515.1655 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 252.5334 526.3847 cm 0 0 m 85.039 0 l S Q q 1 0 0 1 252.5334 515.1655 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 337.5728 526.3847 cm 0 0 m 85.039 0 l S Q q 1 0 0 1 337.5728 515.1655 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 422.6122 526.3847 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 422.6122 515.1655 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 467.9665 526.3847 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 467.9665 515.1655 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 524.6594 515.1655 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 70.8661 514.9155 cm 0 0 m 181.667 0 l S Q q 1 0 0 1 71.1161 503.7042 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 252.5334 514.9155 cm 0 0 m 85.039 0 l S Q q 1 0 0 1 252.5334 503.7042 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 337.5728 514.9155 cm 0 0 m 85.039 0 l S Q q 1 0 0 1 337.5728 503.7042 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 422.6122 514.9155 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 422.6122 503.7042 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 467.9665 514.9155 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 467.9665 503.7042 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 503.7042 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 503.4542 cm 0 0 m 181.667 0 l S Q q 1 0 0 1 71.1161 492.235 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 252.5334 503.4542 cm 0 0 m 85.039 0 l S Q q 1 0 0 1 252.5334 492.235 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 337.5728 503.4542 cm 0 0 m 85.039 0 l S Q q 1 0 0 1 337.5728 492.235 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 422.6122 503.4542 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 422.6122 492.235 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 467.9665 503.4542 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 467.9665 492.235 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 524.6594 492.235 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 70.8661 491.985 cm 0 0 m 181.667 0 l S Q q 1 0 0 1 252.5334 491.985 cm 0 0 m 85.039 0 l S Q q 1 0 0 1 337.5728 491.985 cm 0 0 m 85.039 0 l S Q q 1 0 0 1 422.6122 491.985 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 467.9665 491.985 cm 0 0 m 56.943 0 l S Q q 71.366 595.418 180.917 20.569 re W n /GS0 gs q 1 0 0 1 71.3661 615.9875 cm 0 0 m 180.917 -20.569 l S Q Q BT /GS1 gs /T1_2 1 Tf 8 0 0 8 221.8591 607.6029 Tm (\033\004\002\006\002\003)Tj -18.489 -1.2 Td (\200\006\t\213\b\004\220)Tj 27.13 1.2 Td (\240\004)Tj -2.395 -1.2 Td (\(Me \(Q1;Q3\)\))Tj 12.812 1.2 Td (\b\r\003)Tj -2.182 -1.2 Td (\(Me \(Q1;Q3\)\))Tj /T1_3 1 Tf 10.794 0.6 Td (n)Tj 6.377 0 Td (p)Tj /T1_0 1 Tf -52.536 -2.034 Td (\200\024\030\026\f\021,)Tj /T1_2 1 Tf ( )Tj /T1_0 1 Tf (\035\036\021)Tj /T1_2 1 Tf 23.983 0 Td (34,0)Tj /Span<>> BDC ( )Tj EMC (\(23,5;49,0\))Tj 10.513 0 Td (21,0)Tj /Span<>> BDC ( )Tj EMC (\(18,0; 35,0\))Tj 11.087 0 Td (151)Tj 5.279 0 Td (<)Tj /Span<>> BDC ( )Tj EMC (0,0001)Tj /T1_0 1 Tf -50.862 -1.433 Td (\221\026\n\024\f\021\024\016\021\036\035\034\027\t\005 \f\021\031\035, \002\ \026\035\035)Tj 25.102 0 Td (3,0)Tj /Span<>> BDC ( )Tj EMC (\(2,0; 4,0\))Tj 10.63 0 Td (2,0)Tj /Span<>> BDC ( )Tj EMC (\(1,0; 4,0\))Tj 9.936 0 Td (116)Tj 6.035 0 Td (0,242)Tj -51.703 -1.433 Td (\200\007\031\021\017\036 \032\017\r\024\021\026, \002\026\035\035)Tj 25.102 0 Td (3,0)Tj /Span<>> BDC ( )Tj EMC (\(2,0; 3,0\))Tj 10.63 0 Td (3,0)Tj /Span<>> BDC ( )Tj EMC (\(2,0; 4,0\))Tj 10.186 0 Td (98)Tj 5.785 0 Td (0,357)Tj -51.703 -1.434 Td (\223\026\f\021\024\021\026)Tj /T1_2 1 Tf ( )Tj /T1_0 1 Tf (\007\036\235\036\022\026\006\017\017,)Tj /T1_2 1 Tf ( )Tj /T1_0 1 Tf (\002\026\035\035)Tj /T1_2 1 Tf 24.701 0 Td (5,0)Tj /Span<>> BDC ( )Tj EMC (\(3,0; 5,0\))Tj 10.63 0 Td (3,0)Tj /Span<>> BDC ( )Tj EMC (\(2,0; 4,0\))Tj 10.253 0 Td (117)Tj 5.279 0 Td (<)Tj /Span<>> BDC ( )Tj EMC (0,0001)Tj /T1_0 1 Tf -50.862 -1.433 Td (\215\024\t\r\t \022)Tj /Span<>> BDC ( )Tj EMC (\007\036\235\036\022\026\006\017\017, \002\026\035\035)Tj 25.102 0 Td (2,0)Tj /Span<>> BDC ( )Tj EMC (\(1,0; 3,0\))Tj 10.63 0 Td (2,0)Tj /Span<>> BDC ( )Tj EMC (\(1,0; 3,0\))Tj 9.936 0 Td (107)Tj 6.035 0 Td (0,384)Tj -51.703 -1.433 Td (\253\202\002\007\024\n\017\027\026\035\034\027\t\005 \007\017\f\022\024\n\ \235\024\030\021\273, \002\026\035\035)Tj 24.602 0 Td (10,0)Tj /Span<>> BDC ( )Tj EMC (\(7,0; 14,0\))Tj 10.63 0 Td (12,0)Tj /Span<>> BDC ( )Tj EMC (\(7,0; 16,0\))Tj 10.686 0 Td (97)Tj 5.785 0 Td (0,126)Tj -51.703 -1.434 Td (\253\217\026\f\f\021\030\024\005\f\021\r\024)Tj /T1_2 1 Tf ( )Tj /T1_0 1 Tf (\007\036\235\036\022\026\006\017\017\273,)Tj /T1_2 1 Tf ( )Tj /T1_0 1 Tf (\002\026\035\035)Tj /T1_2 1 Tf 24.701 0 Td (5,0)Tj /Span<>> BDC ( )Tj EMC (\(3,0; 8,0\))Tj 10.352 0 Td (9,5)Tj /Span<>> BDC ( )Tj EMC (\(6,0; 13,0\))Tj 10.809 0 Td (96)Tj 5.001 0 Td (<)Tj /Span<>> BDC ( )Tj EMC (0,0001)Tj /T1_0 1 Tf -50.862 -1.433 Td (\212\035\017\021\036\035\034\027\024\f\021\034 \026\027\026\n\027\036\026\ , \002\026\035\035)Tj 25.102 0 Td (3,0)Tj /Span<>> BDC ( )Tj EMC (\(2,0; 5,0\))Tj 10.63 0 Td (4,0)Tj /Span<>> BDC ( )Tj EMC (\(3,0; 4,0\))Tj 9.936 0 Td (133)Tj 6.035 0 Td (0,426)Tj -51.703 -1.433 Td (\222\027\021\036\027\f\017\r\027\024\f\021\034 \026\023\024\030\024\r \(\ \001\022\026\035\026 \200\036\022\f\027\036\030\026\), \002\026\035\035)Tj /T1_2 1 Tf 24.423 -0.001 Td (9,0)Tj /Span<>> BDC ( )Tj EMC (\(7,0; 13,0\))Tj 10.074 0 Td (14,0)Tj /Span<>> BDC ( )Tj EMC (\(10,0; 18,0\))Tj 11.365 0 Td (95)Tj 5.001 0 Td (<)Tj /Span<>> BDC ( )Tj EMC (0,0001)Tj 1 0.68 0 0.12 k /GS0 gs -0.008 Tc -0.05 Tw 9 0 0 9 70.8661 475.2657 Tm (\020\004\206\f\t\204\004 6.)Tj 0 0 0 1 k /GS1 gs /T1_1 1 Tf ( \212\031\016\205\023\022\024\026\024\020 \030\025\026\202\021\n\t\024\025\ \006\031\t\013\025\004 \024\031\t\024\n\027)Tj /Span<>> BDC ( )Tj EMC (\227 \t\032\026\027\021\031\021\025\031 \033\n)Tj /Span<>> BDC ( )Tj EMC (\013\n\023\025\006\031\t\024\027\031\021\021\020\003 \033\032\025\016\021\ \026\013\026\003 \(U-\013\032\025\024\031\032\025\017 \240\026\021\021\026\ \226\214\025\024\021\025\))Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0 Tc 0 Tw T* [(T)48(able 6)16(.)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf [( R)21(esults of diagnostic tests: rank character)-36.5(istics \(Mann\226Whitney U-test\))]TJ ET /GS2 gs q 1 0 0 1 70.8661 459.9637 cm 0 0 m 76.785 0 l S Q q 1 0 0 1 71.1161 439.1445 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 147.6516 459.9637 cm 0 0 m 155.906 0 l S Q q 1 0 0 1 303.5571 459.9637 cm 0 0 m 70.866 0 l S Q q 1 0 0 1 303.5571 439.1445 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 374.4232 459.9637 cm 0 0 m 70.866 0 l S Q q 1 0 0 1 374.4232 439.1445 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 445.2893 459.9637 cm 0 0 m 39.685 0 l S Q q 1 0 0 1 445.2893 439.1445 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 484.9744 459.9637 cm 0 0 m 39.935 0 l S Q q 1 0 0 1 484.9744 439.1445 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 524.6594 439.1445 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 70.8661 438.8945 cm 0 0 m 76.785 0 l S Q q 1 0 0 1 71.1161 427.4253 cm 0 0 m 0 11.219 l S Q q 1 0 0 1 147.6516 438.8945 cm 0 0 m 155.906 0 l S Q q 1 0 0 1 147.6516 427.6753 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 303.5571 438.8945 cm 0 0 m 70.866 0 l S Q q 1 0 0 1 303.5571 427.6753 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 374.4232 438.8945 cm 0 0 m 70.866 0 l S Q q 1 0 0 1 374.4232 427.6753 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 445.2893 438.8945 cm 0 0 m 39.685 0 l S Q q 1 0 0 1 445.2893 427.6753 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 484.9744 438.8945 cm 0 0 m 39.935 0 l S Q q 1 0 0 1 484.9744 427.6753 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 524.6594 427.6753 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 71.1161 415.9561 cm 0 0 m 0 11.469 l S Q q 1 0 0 1 147.4016 427.4253 cm 0 0 m 156.156 0 l S Q q 1 0 0 1 147.6516 416.2061 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 303.5571 427.4253 cm 0 0 m 70.866 0 l S Q q 1 0 0 1 303.5571 416.2061 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 374.4232 427.4253 cm 0 0 m 70.866 0 l S Q q 1 0 0 1 374.4232 416.2061 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 445.2893 427.4253 cm 0 0 m 39.685 0 l S Q q 1 0 0 1 445.2893 416.2061 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 484.9744 427.4253 cm 0 0 m 39.935 0 l S Q q 1 0 0 1 484.9744 416.2061 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 524.6594 416.2061 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 71.1161 404.4869 cm 0 0 m 0 11.469 l S Q q 1 0 0 1 147.4016 415.9561 cm 0 0 m 156.156 0 l S Q q 1 0 0 1 147.6516 404.7369 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 303.5571 415.9561 cm 0 0 m 70.866 0 l S Q q 1 0 0 1 303.5571 404.7369 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 374.4232 415.9561 cm 0 0 m 70.866 0 l S Q q 1 0 0 1 374.4232 404.7369 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 445.2893 415.9561 cm 0 0 m 39.685 0 l S Q q 1 0 0 1 445.2893 404.7369 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 484.9744 415.9561 cm 0 0 m 39.935 0 l S Q q 1 0 0 1 484.9744 404.7369 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 524.6594 404.7369 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 71.1161 393.0256 cm 0 0 m 0 11.461 l S Q q 1 0 0 1 147.4016 404.4869 cm 0 0 m 156.156 0 l S Q q 1 0 0 1 147.6516 393.2756 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 303.5571 404.4869 cm 0 0 m 70.866 0 l S Q q 1 0 0 1 303.5571 393.2756 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 374.4232 404.4869 cm 0 0 m 70.866 0 l S Q q 1 0 0 1 374.4232 393.2756 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 445.2893 404.4869 cm 0 0 m 39.685 0 l S Q q 1 0 0 1 445.2893 393.2756 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 484.9744 404.4869 cm 0 0 m 39.935 0 l S Q q 1 0 0 1 484.9744 393.2756 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 393.2756 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 71.1161 381.8143 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 147.4016 393.0256 cm 0 0 m 156.156 0 l S Q q 1 0 0 1 147.6516 381.8143 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 303.5571 393.0256 cm 0 0 m 70.866 0 l S Q q 1 0 0 1 303.5571 381.8143 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 374.4232 393.0256 cm 0 0 m 70.866 0 l S Q q 1 0 0 1 374.4232 381.8143 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 445.2893 393.0256 cm 0 0 m 39.685 0 l S Q q 1 0 0 1 445.2893 381.8143 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 484.9744 393.0256 cm 0 0 m 39.935 0 l S Q q 1 0 0 1 484.9744 381.8143 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 381.8143 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 381.5643 cm 0 0 m 76.785 0 l S Q q 1 0 0 1 71.1161 370.353 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 147.6516 381.5643 cm 0 0 m 155.906 0 l S Q q 1 0 0 1 303.5571 381.5643 cm 0 0 m 70.866 0 l S Q q 1 0 0 1 303.5571 370.353 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 374.4232 381.5643 cm 0 0 m 70.866 0 l S Q q 1 0 0 1 374.4232 370.353 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 445.2893 381.5643 cm 0 0 m 39.685 0 l S Q q 1 0 0 1 445.2893 370.353 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 484.9744 381.5643 cm 0 0 m 39.935 0 l S Q q 1 0 0 1 484.9744 370.353 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 370.353 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 370.103 cm 0 0 m 76.785 0 l S Q q 1 0 0 1 71.1161 358.6417 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 147.6516 370.103 cm 0 0 m 155.906 0 l S Q q 1 0 0 1 147.6516 358.8917 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 303.5571 370.103 cm 0 0 m 70.866 0 l S Q q 1 0 0 1 303.5571 358.8917 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 374.4232 370.103 cm 0 0 m 70.866 0 l S Q q 1 0 0 1 374.4232 358.8917 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 445.2893 370.103 cm 0 0 m 39.685 0 l S Q q 1 0 0 1 445.2893 358.8917 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 484.9744 370.103 cm 0 0 m 39.935 0 l S Q q 1 0 0 1 484.9744 358.8917 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 358.8917 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 71.1161 347.4305 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 147.4016 358.6417 cm 0 0 m 156.156 0 l S Q q 1 0 0 1 147.6516 347.4305 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 303.5571 358.6417 cm 0 0 m 70.866 0 l S Q q 1 0 0 1 303.5571 347.4305 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 374.4232 358.6417 cm 0 0 m 70.866 0 l S Q q 1 0 0 1 374.4232 347.4305 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 445.2893 358.6417 cm 0 0 m 39.685 0 l S Q q 1 0 0 1 445.2893 347.4305 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 484.9744 358.6417 cm 0 0 m 39.935 0 l S Q q 1 0 0 1 484.9744 347.4305 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 347.4305 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 347.1805 cm 0 0 m 76.785 0 l S Q q 1 0 0 1 71.1161 335.7192 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 147.6516 347.1805 cm 0 0 m 155.906 0 l S Q q 1 0 0 1 147.6516 335.9692 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 303.5571 347.1805 cm 0 0 m 70.866 0 l S Q q 1 0 0 1 303.5571 335.9692 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 374.4232 347.1805 cm 0 0 m 70.866 0 l S Q q 1 0 0 1 374.4232 335.9692 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 445.2893 347.1805 cm 0 0 m 39.685 0 l S Q q 1 0 0 1 445.2893 335.9692 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 484.9744 347.1805 cm 0 0 m 39.935 0 l S Q q 1 0 0 1 484.9744 335.9692 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 335.9692 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 71.1161 324.2579 cm 0 0 m 0 11.461 l S Q q 1 0 0 1 147.4016 335.7192 cm 0 0 m 156.156 0 l S Q q 1 0 0 1 147.6516 324.5079 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 303.5571 335.7192 cm 0 0 m 70.866 0 l S Q q 1 0 0 1 303.5571 324.5079 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 374.4232 335.7192 cm 0 0 m 70.866 0 l S Q q 1 0 0 1 374.4232 324.5079 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 445.2893 335.7192 cm 0 0 m 39.685 0 l S Q q 1 0 0 1 445.2893 324.5079 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 484.9744 335.7192 cm 0 0 m 39.935 0 l S Q q 1 0 0 1 484.9744 324.5079 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 324.5079 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 71.1161 312.7966 cm 0 0 m 0 11.461 l S Q q 1 0 0 1 147.4016 324.2579 cm 0 0 m 156.156 0 l S Q q 1 0 0 1 147.6516 313.0466 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 303.5571 324.2579 cm 0 0 m 70.866 0 l S Q q 1 0 0 1 303.5571 313.0466 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 374.4232 324.2579 cm 0 0 m 70.866 0 l S Q q 1 0 0 1 374.4232 313.0466 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 445.2893 324.2579 cm 0 0 m 39.685 0 l S Q q 1 0 0 1 445.2893 313.0466 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 484.9744 324.2579 cm 0 0 m 39.935 0 l S Q q 1 0 0 1 484.9744 313.0466 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 313.0466 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 71.1161 301.5853 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 147.4016 312.7966 cm 0 0 m 156.156 0 l S Q q 1 0 0 1 147.6516 301.5853 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 303.5571 312.7966 cm 0 0 m 70.866 0 l S Q q 1 0 0 1 303.5571 301.5853 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 374.4232 312.7966 cm 0 0 m 70.866 0 l S Q q 1 0 0 1 374.4232 301.5853 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 445.2893 312.7966 cm 0 0 m 39.685 0 l S Q q 1 0 0 1 445.2893 301.5853 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 484.9744 312.7966 cm 0 0 m 39.935 0 l S Q q 1 0 0 1 484.9744 301.5853 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 301.5853 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 301.3353 cm 0 0 m 76.785 0 l S Q q 1 0 0 1 147.6516 301.3353 cm 0 0 m 155.906 0 l S Q q 1 0 0 1 303.5571 301.3353 cm 0 0 m 70.866 0 l S Q q 1 0 0 1 374.4232 301.3353 cm 0 0 m 70.866 0 l S Q q 1 0 0 1 445.2893 301.3353 cm 0 0 m 39.685 0 l S Q q 1 0 0 1 484.9744 301.3353 cm 0 0 m 39.935 0 l S Q q 71.366 439.144 231.941 20.569 re W n /GS0 gs q 1 0 0 1 71.3661 459.7137 cm 0 0 m 231.941 -20.569 l S Q Q BT /GS1 gs /T1_2 1 Tf 8 0 0 8 272.8827 451.3292 Tm (\033\004\002\006\002\003)Tj -24.866 -1.2 Td (\200\006\t\213\b\004\220)Tj 32.622 1.2 Td (\240\004)Tj -2.395 -1.2 Td (\(Me \(Q1;Q3\)\))Tj 11.041 1.2 Td (\b\r\003)Tj -2.182 -1.2 Td (\(Me \(Q1;Q3\)\))Tj /T1_3 1 Tf 9.553 0.6 Td (n)Tj 4.96 0 Td (p)Tj /T1_0 1 Tf -53.599 -2.033 Td (\222\030\030\017\020\024\f\022\024\023\017\016)Tj 12.709 -0.001 Td (\212\035\017\027\026)Tj /T1_2 1 Tf ( )Tj /T1_0 1 Tf (\f\017\020\n\024\r\017\007\027\024\005)Tj /T1_2 1 Tf ( )Tj /T1_0 1 Tf (\022\017\001\022\017,)Tj /T1_2 1 Tf ( )Tj /T1_0 1 Tf (\f\n)Tj /T1_2 1 Tf 16.65 0 Td (80,0)Tj /Span<>> BDC ( )Tj EMC (\(70,0; 85,0\))Tj 8.858 0 Td (62,0)Tj /Span<>> BDC ( )Tj EMC (\(60,0; 75,0\))Tj 10.124 0 Td (78)Tj 4.257 0 Td (0,001)Tj /T1_0 1 Tf -39.097 -1.434 Td (\234\017\030\017\027\026)Tj /T1_2 1 Tf ( )Tj /T1_0 1 Tf (\023\030\016\n\024\005)Tj /T1_2 1 Tf ( )Tj /T1_0 1 Tf (\022\017\001\022\017,)Tj /T1_2 1 Tf ( )Tj /T1_0 1 Tf (\f\n)Tj /T1_2 1 Tf 16.414 0 Td (8,6)Tj /Span<>> BDC ( )Tj EMC (\(7,0; 10,0\))Tj 8.302 0 Td (10,5)Tj /Span<>> BDC ( )Tj EMC (\(10,0; 12,0\))Tj 9.846 0 Td (111)Tj 4.535 0 Td (0,000)Tj /T1_0 1 Tf -40.271 -1.434 Td (\234\017\030\017\027\026)Tj /T1_2 1 Tf ( )Tj /T1_0 1 Tf (\f\017\020\n\024\r\017\007\027\024\005)Tj /T1_2 1 Tf ( )Tj /T1_0 1 Tf (\022\017\001\022\017,)Tj /T1_2 1 Tf ( )Tj /T1_0 1 Tf (\f\n)Tj /T1_2 1 Tf 17.032 0 Td (11,5)Tj /Span<>> BDC ( )Tj EMC (\(10,0; 13,7\))Tj 9.414 0 Td (9,0)Tj /Span<>> BDC ( )Tj EMC (\(7,5; 11,0\))Tj 9.568 0 Td (99)Tj 4.257 0 Td (0,000)Tj /T1_0 1 Tf -42.4 -1.433 Td (\234\017\030\017\027\026 \023\024\023\036\030\036\004\027\024\005 \024\002\ \024\007\024\004\027\024\005 \022\017\001\022\017, \f\n)Tj 20.146 0 Td (7,1)Tj /Span<>> BDC ( )Tj EMC (\(5,8; 11,0\))Tj 9.108 0 Td (7,7)Tj /Span<>> BDC ( )Tj EMC (\(6,0; 9,5\))Tj 8.945 0 Td (40)Tj 4.368 0 Td (0,925)Tj -42.591 -1.433 Td (\234\017\030\017\027\026 \r\024\f\b\024\007\016\013\036\005 \024\002\024\ \007\024\004\027\024\005 \022\017\001\022\017, \f\n)Tj 20.42 0 Td (7,5)Tj /Span<>> BDC ( )Tj EMC (\(5,8; 9,2\))Tj 8.858 0 Td (7,5)Tj /Span<>> BDC ( )Tj EMC (\(6,5; 9,0\))Tj 8.945 0 Td (29)Tj 4.368 0 Td (0,647)Tj -52.766 -1.433 Td (\200\030\036\n\016 \021\030\026\027\017\021\026 \023\024)Tj /Span<>> BDC ( )Tj EMC (\240\025\230, \002\026\035\035)Tj 30.594 0 Td (5,0)Tj /Span<>> BDC ( )Tj EMC (\(4,0; 5,0\))Tj 8.858 0 Td (5,0)Tj /Span<>> BDC ( )Tj EMC (\(4,0; 5,0\))Tj 8.945 0 Td (87)Tj 4.368 0 Td (0,557)Tj -52.766 -1.433 Td (\212\036\235\036\022\024\020\030\026\235\017\016)Tj 17.326 0 Td (\230)Tj 4.664 0 0 4.664 216.2458 359.8764 Tm (\212\213\205)Tj /T1_1 1 Tf 8 0 0 8 224.2351 361.4764 Tm (, )Tj /T1_0 1 Tf (\f\036\022)Tj 11.058 0 Td (39,0)Tj /Span<>> BDC ( )Tj EMC (\(27,5; 70,0\))Tj 8.858 0 Td (60,0)Tj /Span<>> BDC ( )Tj EMC (\(30,0; 70,0\))Tj 9.695 0 Td (68)Tj 4.368 0 Td (0,570)Tj /T1_1 1 Tf -35.223 -1.433 Td (V)Tj /T1_0 1 Tf 4.664 0 0 4.664 218.1278 348.4151 Tm (\210\221\230)Tj /T1_1 1 Tf 8 0 0 8 225.0491 350.0151 Tm (, )Tj /T1_0 1 Tf (\n\035)Tj 10.957 0 Td (35,0)Tj /Span<>> BDC ( )Tj EMC (\(20,0; 60,0\))Tj 8.858 0 Td (50,0)Tj /Span<>> BDC ( )Tj EMC (\(25,0; 85,0\))Tj 9.695 0 Td (76)Tj 4.368 0 Td (0,146)Tj -52.766 -1.433 Td (\222\f\f\035\036\007\024\r\026\027\017\036 )Tj T* (\030\036\036\030\r\031\026\030\027\024\005 )Tj T* (\235\031\027\022\006\017\017 \023\030\016\n\024\005 )Tj T* (\022\017\001\022\017)Tj 17.336 3.6 Td (\215\215\223, \n\035)Tj 12.008 0 Td (102,0)Tj /Span<>> BDC ( )Tj EMC (\(40,0; 109,0\))Tj 8.858 0 Td (102,0)Tj /Span<>> BDC ( )Tj EMC (\(80,0; 105,0\))Tj 9.945 0 Td (125)Tj 4.618 0 Td (0,316)Tj -35.453 -1.433 Td (\204\215\210,)Tj /T1_1 1 Tf ( )Tj /T1_0 1 Tf (\n\035)Tj 11.781 0 Td (575,0)Tj /Span<>> BDC ( )Tj EMC (\(210,0; 700,0\))Tj 8.858 0 Td (750,0)Tj /Span<>> BDC ( )Tj EMC (\(500,0; 940,0\))Tj 10.445 0 Td (81)Tj 4.368 0 Td (0,060)Tj /T1_1 1 Tf -37.305 -1.433 Td (I)Tj /T1_0 1 Tf 4.664 0 0 4.664 200.3312 314.0312 Tm (\204\215\210)Tj /T1_1 1 Tf 8 0 0 8 208.8382 315.6313 Tm (, )Tj /T1_0 1 Tf (\n\035/\n\n)Tj /T1_1 1 Tf ( )Tj /T1_0 1 Tf (\030\021.\f\021.)Tj 12.983 0 Td (27,3)Tj /Span<>> BDC ( )Tj EMC (\(17,6; 48,1\))Tj 8.858 0 Td (32,5)Tj /Span<>> BDC ( )Tj EMC (\(20,2; 55,0\))Tj 9.695 0 Td (63)Tj 4.368 0 Td (0,690)Tj -37.935 -1.433 Td (\244V/\244P,)Tj /T1_1 1 Tf ( )Tj /T1_0 1 Tf (\n\035/\n\n)Tj /T1_1 1 Tf ( )Tj /T1_0 1 Tf (\030\021.\f\021.)Tj 15.013 0 Td (44,7)Tj /Span<>> BDC ( )Tj EMC (\(29,7; 84,1\))Tj 8.858 0 Td (38,9)Tj /Span<>> BDC ( )Tj EMC (\(20,9; 73,6\))Tj 9.695 0 Td (54)Tj 4.368 0 Td (0,470)Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\033\030\031\030\213\b)-20.9(\035\231\213\233\t \021\032)50(\b)42(\032\231\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj -51.938 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 23, \023\0221)69(, 202)69(4)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 23, \023\0221)69(, 202)69(4)]TJ /T1_5 1 Tf 25 0 0 25 28.1024 56.0378 Tm (36)Tj ET endstream endobj 2103 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 2104 0 obj <>/ExtGState<>/Font<>/ProcSet[/PDF/Text]/Properties<>/Shading<>/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 2105 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 2106 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 2107 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 2297 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\210\013\n)-10(\026)11(\025\002\020 \002\220\006\n\013 \222\013\r\025\002\025\026)11(\013 \006\220\202)10(\024\025\r\220\201\001\025\203 \n\220\n\220 \215\022\221\013\227\220\016\ \001\026)11(\025\r )]TJ 0 -1 TD [(\006\022\220\201\220\025\221\013\026\220\017\016\006\n\220\024 \024\016\202\ )10.1(\013\n)10(\025\007\025\001/\024\016\202)10(\013\002\016\n)-9.9(\026)-20(\215\024)]TJ 33.279 1 Td [(Risk factor)20(s of sigmoid v)10(olv)10(ulus in patients with idiopathic megacolon)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0.082 Tw 10 0 0 10 42.5197 566.5159 Tm (\243)Tj /Span<>> BDC ( )Tj EMC 1 0 Td (\217\036\027\021\020\036\027\024\r\f\022\026\016 \007\036\235\036\022\024\ \020\030\026\235\017\016 \f)Tj /Span<>> BDC ( )Tj EMC (\002\026\030\017\036\r\024\005 \r\r\036\f\034\033 )Tj 0 Tw -1 -1.218 Td (\()Tj /T1_2 1 Tf (n)Tj /T1_1 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (76\))Tj ET q 0 0 566.929 793.701 re W n 0 0 0 1 K 4 M q 1 0 0 1 45.9677 545.0399 cm 0 0 m 0 0.8 -0.648 1.456 -1.448 1.456 c -2.248 1.456 -2.896 0.8 -2.896 0 c -2.896 -0.8 -2.248 -1.44 -1.448 -1.44 c -0.648 -1.44 0 -0.8 0 0 c h S Q Q BT 0 0 0 0 k /GS0 gs /T1_1 1 Tf 8 0 0 8 42.5197 542.1599 Tm (\243)Tj 0 0 0 1 k /GS1 gs /Span<>> BDC 10 0 0 10 46.5197 542.1599 Tm [( )-267( )]TJ EMC 0.5 0 Td (\210\f\021\026\021\024\004\027\t\005 \024\002\255\036\n \(V)Tj 5.83 0 0 5.83 138.4686 540.1599 Tm (\024\f\021)Tj 10 0 0 10 146.1466 542.1599 Tm (\);)Tj ET q 0 0 566.929 793.701 re W n 0 0 0 1 K 4 M q 1 0 0 1 45.9677 532.8619 cm 0 0 m 0 0.8 -0.648 1.456 -1.448 1.456 c -2.248 1.456 -2.896 0.8 -2.896 0 c -2.896 -0.8 -2.248 -1.44 -1.448 -1.44 c -0.648 -1.44 0 -0.8 0 0 c h S Q Q BT 0 0 0 0 k /GS0 gs /T1_1 1 Tf 8 0 0 8 42.5197 529.9819 Tm (\243)Tj 0 0 0 1 k /GS1 gs /Span<>> BDC 10 0 0 10 46.5197 529.9819 Tm [( )-267( )]TJ EMC 0.5 0 Td (\200\030\036\n\016 \024\023\024\030\024\032\027\036\027\017\016 \(T)Tj 5.83 0 0 5.83 146.4683 527.9819 Tm (\007\036\235)Tj 10 0 0 10 155.9594 529.9819 Tm (\).)Tj 0.951 Tw -11.344 -1.218 Td [(\215\024 \021\036\b\027\017\004\036\f\022\017\n )0.5(\023\030\017\004\017\027\026\n \r\030\036\n\016 \024\023\024\030\024\032\ \027\036)]TJ 0 Tw (-)Tj 0.608 Tw 0 -1.218 TD (\027\017\016 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\007\036\235\036\022\024\020\030\026\235\017\017 \002\t\035\024 \026\030\ \036\020\017\f\021\030\017\030\024\r\026\027\024 )Tj 0.281 Tw T* (\031)Tj /Span<>> BDC ( )Tj EMC (68 \017)Tj /Span<>> BDC ( )Tj EMC (76)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r, \022\024\021\024\030\t\n \220\021\024\ \017\f\f\035\036\007\024\r\026\027\017\036 )Tj 0 Tw T* (\r\t\023\024\035\027\016\035\024\f\034.)Tj 0.17 Tw T* (\243)Tj /Span<>> BDC ( )Tj EMC 1 0 Td (\222\f\f\035\036\007\024\r\026\027\017\036 \021\030\026\027\017\021\026\ \023\024)Tj /Span<>> BDC ( )Tj EMC (\240\025\230 \002\026\030\017\036\r\024\005 \r\r\036\f\017 )Tj 0.049 Tw -1 -1.218 Td (\r)Tj /Span<>> BDC ( )Tj EMC (\021\036\004\036\027\017\036 5 \007\027\036\005 \()Tj /T1_2 1 Tf 0 Tw (n)Tj /T1_1 1 Tf 0.049 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (87\). \200)Tj /Span<>> BDC ( )Tj EMC (\f\021\026\021\017\f\021\017\004\036\f\022\024\n \026\027\026\035\017\036\ )Tj 0.28 Tw T* (\r\t\030\026\032\036\027\027\024\f\021\034 \021\030\026\027\017\021\027\ \t\b \027\026\030\031\001\036\027\017\005 \024\006\036\027\017\r\026\035\ \026\f\034 )Tj 0.038 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\002\026\035\035\026\b \(\230\026\002\035.)Tj /Span<>> BDC ( )Tj EMC (2\). \025\030\024\n\036 \021\024\020\024, \031\004\017\021\t\r\026\035\024\ \f\034 \027\026\035\017\004\017\036 )Tj 0.241 Tw T* (\017\035\017 \024\021\f\031\021\f\021\r\017\036 \007\017\f\021\026\035\034\ \027\024\005 \026\007\036\030\032\022\017, \021\024 \036\f\021\034 \023\ \030\036)Tj 0 Tw (-)Tj 0.182 Tw T* (\017\n\031\013\036\f\021\r\036\027\027\024\005 \026\007\036\030\032\022\ \017 \022\024\027\021\030\026\f\021\026 \r)Tj /Span<>> BDC ( )Tj EMC (\f\017\020\n\024\r\017\007\027\024\005 )Tj 0 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\023\030\016\n\024\005 \022\017\001\022\026\b.)Tj -0.04 Tw T* (\243)Tj /Span<>> BDC ( )Tj EMC 1 0 Td [(\222\f\f\035\036\007\024\r\026\027\017\036 \030\036\036\030\r\031\026\030\ \027\024\005 )0.5(\235\031\027\022\006\017\017 \023\030\016\n\024\005 )0.5(\022\017\001)]TJ 0 Tw (-)Tj -1 -1.218 Td (\022\017 \()Tj /T1_2 1 Tf (n)Tj /T1_1 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (125\))Tj ET q 0 0 566.929 793.701 re W n 0 0 0 1 K 4 M q 1 0 0 1 45.9677 362.3699 cm 0 0 m 0 0.8 -0.648 1.456 -1.448 1.456 c -2.248 1.456 -2.896 0.8 -2.896 0 c -2.896 -0.8 -2.248 -1.44 -1.448 -1.44 c -0.648 -1.44 0 -0.8 0 0 c h S Q Q BT 0 0 0 0 k /GS0 gs /T1_1 1 Tf 8 0 0 8 42.5197 359.4899 Tm (\243)Tj 0 0 0 1 k /GS1 gs /Span<>> BDC 10 0 0 10 46.5197 359.4899 Tm [( )-267( )]TJ EMC 0.5 0 Td (\215\036\030\r\t\005 \023\024\030\024\020 \004\031\r\f\021\r\017\021\036\ \035\034\027\024\f\021\017 \(\215\215\223, \n\035\);)Tj ET q 0 0 566.929 793.701 re W n 0 0 0 1 K 4 M q 1 0 0 1 45.9677 350.1919 cm 0 0 m 0 0.8 -0.648 1.456 -1.448 1.456 c -2.248 1.456 -2.896 0.8 -2.896 0 c -2.896 -0.8 -2.248 -1.44 -1.448 -1.44 c -0.648 -1.44 0 -0.8 0 0 c h S Q Q BT 0 0 0 0 k /GS0 gs /T1_1 1 Tf 8 0 0 8 42.5197 347.3119 Tm (\243)Tj 0 0 0 1 k /GS1 gs /Span<>> BDC 10 0 0 10 46.5197 347.3119 Tm [( )-267( )]TJ EMC 0.5 0 Td (\204\026\022\f\017\n\026\035\034\027\024 \023\036\030\036\027\024\f\017\n\ \t\005 \024\002\255\036\n \(\204\215\210, \n\035\);)Tj ET q 0 0 566.929 793.701 re W n 0 0 0 1 K 4 M q 1 0 0 1 45.9677 338.0139 cm 0 0 m 0 0.8 -0.648 1.456 -1.448 1.456 c -2.248 1.456 -2.896 0.8 -2.896 0 c -2.896 -0.8 -2.248 -1.44 -1.448 -1.44 c -0.648 -1.44 0 -0.8 0 0 c h S Q Q BT 0 0 0 0 k /GS0 gs /T1_1 1 Tf 8 0 0 8 42.5197 335.1339 Tm (\243)Tj 0 0 0 1 k /GS1 gs 0.261 Tw /Span<>> BDC 10 0 0 10 46.5197 335.1339 Tm [( )-6( )]TJ EMC 0.5 0 Td (\222\027\007\036\022\f \n\026\022\f\017\n\026\035\034\027\024 \023\036\030\ \036\027\024\f\017\n\024\020\024 \024\002\255\036\n\026 \(I)Tj 0 Tw 5.83 0 0 5.83 251.1382 333.1339 Tm (\204\215\210)Tj 10 0 0 10 261.7721 335.1339 Tm (, )Tj 0.048 Tw -21.025 -1.218 Td (\n\035/\n\n \030\021. \f\021.\))Tj /Span<>> BDC ( )Tj EMC (\227 \024\021\027\024\001\036\027\017\036 \n\026\022\f\017\n\026\035\034\ \027\024 \023\036\030\036\027\024)Tj 0 Tw (-)Tj 0.113 Tw T* (\f\017\n\024\020\024 \024\002\255\036\n\026 \022)Tj /Span<>> BDC ( )Tj EMC (\r\036\035\017\004\017\027\036 \f\024\007\026\r\026\036\n\024\020\024 \017\ \n \024\f\021\026)Tj 0 Tw (-)Tj T* (\021\024\004\027\024\020\024 \030\036\022\021\026\035\034\027\024\020\024\ \007\026\r\035\036\027\017\016;)Tj ET q 0 0 566.929 793.701 re W n 0 0 0 1 K 4 M q 1 0 0 1 45.9677 289.3019 cm 0 0 m 0 0.8 -0.648 1.456 -1.448 1.456 c -2.248 1.456 -2.896 0.8 -2.896 0 c -2.896 -0.8 -2.248 -1.44 -1.448 -1.44 c -0.648 -1.44 0 -0.8 0 0 c h S Q Q BT 0 0 0 0 k /GS0 gs /T1_1 1 Tf 8 0 0 8 42.5197 286.4219 Tm (\243)Tj 0 0 0 1 k /GS1 gs 0.04 Tw /Span<>> BDC 10 0 0 10 46.5197 286.4219 Tm [( )-227( )]TJ EMC 0.5 0 Td (\025\024\220\235\235\017\006\017\036\027\021 \026\007\026\023\021\026\006\ \017\017 \(\244V/\244P, \n\035/\n\n \030\021. \f\021.\))Tj /Span<>> BDC ( )Tj EMC (\227 )Tj -0.002 Tw T* (\024\021\027\024\001\036\027\017\036 \023\030\017\030\024\f\021\026 \024\ \002\255\036\n\026 \022)Tj /Span<>> BDC ( )Tj EMC (\023\030\017\030\024\f\021\031 \024\f\021\026\021\024\004\027\024)Tj 0 Tw (-)Tj 0.041 Tw T* (\020\024 \007\026\r\035\036\027\017\016 \024\021 \023\024\030\024\020\026\ \004\031\r\f\021\r\017\021\036\035\034\027\024\f\021\017 \007\024)Tj /Span<>> BDC ( )Tj EMC (\n\026\022\f\017)Tj 0 Tw (-)Tj T* (\n\026\035\034\027\024 \023\036\030\036\027\024\f\017\n\024\020\024 \024\ \002\255\036\n\026.)Tj 0.404 Tw -0.9 -1.218 Td [(\211 )0.5(62 )0.5(\023\026\006\017\036\027\021\024\r )0.5(\023\030\017)]TJ /Span<>> BDC ( )Tj EMC 9.883 0 Td [(\017\f\f\035\036\007\024\r\026\027\017\017 )0.6(\030\036\036\030\r\031\026\030\027\024\005 )]TJ 0.4 Tw -9.883 -1.218 Td (\235\031\027\022\006\017\017 \023\030\016\n\024\005 \022\017\001\022\017\ \030\036\020\017\f\021\030\017\030\024\r\026\035\017\f\034 \021\024\035\ \034\022\024 )Tj 0.035 Tw T* [(\024\002\255\036\n\t \r\r\024\007\017\n\024\020\024 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC [(\030\036\022\021\026\035\034\027\t\005 )0.5(\002\026\035\035\024\027 )0.5(\r\024\007\031\b\026, )0.5(\f\024)]TJ 0 Tw (-)Tj 0.095 Tw T* (\024\021\r\036\021\f\021\r\031\033\013\017\036 \023\024\030\024\020\026\n\ \004\031\r\f\021\r\017\021\036\035\034\027\024\f\021\017, \002\036 \031\ \004\036\021\026 )Tj 0.275 Tw T* [(\f\024\007\026\r\026\036\n\024\020\024 \017\n\017 \024\f\021\026\021\024\ \004\027\024\020\024 )0.5(\030\036\022\021\026\035\034\027\024\020\024 \007\026\r\035\036)]TJ 0 Tw (-)Tj -0.006 Tw T* (\027\017\016. \215\024\220\021\024\n\031 \030\026\f\004\036\021 \017\027\ \007\036\022\f\026 \n\026\022\f\017\n\026\035\034\027\024 \023\036\030\036\ \027\024\f\017)Tj 0 Tw (-)Tj 0.087 Tw T* (\n\024\020\024 \024\002\255\036\n\026 \017)Tj /Span<>> BDC ( )Tj EMC (\022\024\220\235\235\017\006\017\036\027\021\026 \026\007\026\023\021\026\ \006\017\017 \002\t\035 \027\036\r\024)Tj 0 Tw (-)Tj 0.113 Tw T* [(\n\024\032\036\027. )0.5(\213\013\036 )0.6(\r)]TJ /Span<>> BDC ( )Tj EMC 6.14 0 Td [(9 )0.5(\027\026\002\035\033\007\036\027\017\016\b )0.6(\027\036 )0.5(\002\t\035\024 )0.6(\r\024\n\024\032\027\024\f\021\017 )]TJ 0.203 Tw -6.14 -1.218 Td (\022\026\035\034\022\031\035\016\006\017\017 \022\024\220\235\235\017\006\ \017\036\027\021\026 \026\007\026\023\021\026\006\017\017 \r)Tj /Span<>> BDC ( )Tj EMC (\f\017\035\031 \021\024\020\024, )Tj -0.03 Tw T* (\004\021\024 \023\026\006\017\036\027\021\t \024\022\026\026\035\017\f\034\ \027\036 \r)Tj /Span<>> BDC ( )Tj EMC (\f\024\f\021\024\016\027\017\017 \007\017\235\235\036\030\036\027\006\017\ )Tj 0 Tw (-)Tj 0.073 Tw T* (\030\024\r\026\021\034 \023\036\030\r\t\005 \023\024\030\024\020 \004\031\ \r\f\021\r\017\021\036\035\034\027\024\f\021\017 \023\030\016\n\024\005 \ \022\017\001)Tj 0 Tw (-)Tj T* (\022\017 \022)Tj /Span<>> BDC ( )Tj EMC (\027\026\023\024\035\027\036\027\017\033.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0.01 Tc 0.018 Tw 14 0 0 14 275.0305 566.5159 Tm [(\032\024)52(\026)45(\024\031\032\024\031\224\034\032\027\031\030)5( \026\022\026)-10(\r\031\020)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0 Tc 0.117 Tw 10 0 0 10 274.9606 542.1599 Tm (\221\021\026\021\017\f\021\017\004\036\f\022\017\005 \026\027\026\035\017\  \r\t\023\024\035\027\016\035\f\016 \f)Tj /Span<>> BDC ( )Tj EMC (\023\024\n\024\013\034\033 \023\030\024)Tj 0 Tw (-)Tj -0.046 Tw T* [(\020\030\026\n\n\t S)15(t)15(a)15(t)-32(ist)-32(ica \r\036\030\f\017\017 13.3 \(TIBC)13.1(O, \221\234\202\). \211\004\017\021\t\r\026\016 )]TJ -0.031 Tw T* [(\030\026\f\023\030\036\007\036\035\036\027\017\036, )0.6(\024\021\035\017\004\027\024\036 )0.5(\024\021 )0.5(\027\024\030\n\026\035\034\027\024\020\024, )0.6(\031)]TJ /Span<>> BDC ( )Tj EMC 18.138 0 Td (\002\024\035\034\001\017\027)Tj 0 Tw (-)Tj 0.177 Tw -18.138 -1.218 Td [(\f\021\r\026 \023\030\017\027\026\022\024\r, \007\026\027\027\t\036 )0.5(\023\030\036\007\f\021\026\r\035\016\035\017\f\034 \n\036\007\017\026\027\ \026\n\017 )]TJ 0.051 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (1-\n \017)Tj /Span<>> BDC ( )Tj EMC (3-\n \022\r\026\030\021\017\035\016\n\017. \211\027\017\r\026\030\017\026\ \027\021\027\t\005 \026\027\026\035\017 \023\030\024)Tj 0 Tw (-)Tj 0.064 Tw T* (\017\r\024\007\017\035\f\016 \023\031\021\036\n \f\030\026\r\027\036\027\ \017\016 \020\030\031\023\023 \023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\026\r\024)Tj 0 Tw (-)Tj 0.165 Tw T* (\030\024\021\026\n\017 \017)Tj /Span<>> BDC ( )Tj EMC (\002\036 \023\024)Tj /Span<>> BDC ( )Tj EMC (\002\017\027\026\030\027\t\n \023\030\017\027\026\022\026\n\226 \f)Tj /Span<>> BDC ( )Tj EMC (\023\024\n\024\013\034\033 )Tj 0.14 Tw T* (\007\r\031\f\021\024\030\024\027\027\036\020\024 \021\024\004\027\024\020\ \024 \022\030\017\021\036\030\017\016 \205\017\001\036\030\026, \026)Tj /Span<>> BDC ( )Tj EMC (\023\024 \030\026\027)Tj 0 Tw (-)Tj 0.11 Tw T* (\020\024\r\t\n \(\002\026\035\035\034\027\026\016 \024\006\036\027\022\026\ \))Tj /Span<>> BDC ( )Tj EMC (\227 \f)Tj /Span<>> BDC ( )Tj EMC (\023\024\n\024\013\034\033 U-\022\030\017\021\036\030\017\016 )Tj 0.209 Tw T* (\204\026\027\027\026\226\211\017\021\027\017. \204\027\024\020\024\235\026\ \022\021\024\030\027\t\005 \026\027\026\035\017 \023\030\024\r\024\007\017\ \035\f\016 )Tj -0.022 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\023\024\n\024\013\034\033 \031\030\026\r\027\036\027\017\005 \n\027\024\ \032\036\f\021\r\036\027\027\024\005 \035\024\020\017\f\021\017\004\036\f\ \022\024\005 )Tj 0.028 Tw T* (\030\036\020\030\036\f\f\017\017, \020\007\036 \026\r\017\f\017\n\024\005\ \023\036\030\036\n\036\027\027\024\005 \r\t\f\021\031\023\026\035\026 \002\ \017)Tj 0 Tw (-)Tj 0.189 Tw T* (\027\026\030\027\026\016 \023\036\030\036\n\036\027\027\026\016 \253\030\ \026\r\017\021\017\036 \026\r\024\030\024\021\026\273. \217\026\035\017\ \004\017\016 )Tj -0.005 Tw T* (\023\030\017\027\026\r\026\035\017\f\034 \f\021\026\021\017\f\021\017\004\ \036\f\022\017 \027\026\004\017\n\t\n\017 \023\030\017)Tj /Span<>> BDC ( )Tj EMC /T1_2 1 Tf 0 Tw (p)Tj /T1_1 1 Tf -0.005 Tw /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (0,05. )Tj -0.021 Tw T* (\215\024\f\021\030\024\036\027\017\036 \027\024\n\024\020\030\026\n\n\t \ \024\f\031\013\036\f\021\r\035\016\035\024\f\034 \f)Tj /Span<>> BDC ( )Tj EMC (\017\f\023\024\035\034\024)Tj 0 Tw (-)Tj T* [(\r\026\027\017\036\n \002\017\002\035\017\024\021\036\022\017 RMSR-S)15.2(tudio \r\036\030\f\017\017 4.3.1.)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 275.0305 322.9559 Tm [(\033\034\020)21(\223)50(\r\241)46(\024)52(\026)45(\024\232)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0 Tc 0.244 Tw 10 0 0 10 274.9606 298.5999 Tm (\204\036\007\017\026\027\026 \r\024\030\026\f\021\026 \024\002\013\036\005\ \020\030\031\023\023\t \023\026\006\017\036\027\021\024\r \f\024\f\021\026\ )Tj 0 Tw (-)Tj 0.044 Tw T* (\r\017\035\026 24,0 \(18,0; 41,0\) \020\024\007\026. \204\031\032\004\017\ \027 \002\t\035\024 84)Tj /Span<>> BDC ( )Tj EMC (\(55,6%\), )Tj 0 Tw T* (\032\036\027\013\017\027)Tj /Span<>> BDC ( )Tj EMC (\227 67)Tj /Span<>> BDC ( )Tj EMC (\(44,4%\).)Tj 0.084 Tw T* [(\211 )0.5(47)]TJ /Span<>> BDC ( )Tj EMC 2.127 0 Td [(\(31,1%\) )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC [(151 )0.5(\023\026\006\017\036\027\021\026 )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC [(\017\007\017\024\023\026\021\017\004\036\f\022\017\n )0.5(\n\036)]TJ 0 Tw (-)Tj 0.363 Tw -2.127 -1.218 Td (\020\026\022\024\035\024\027/\n\036\020\026\030\036\022\021\031\n \026\r\ \024\030\024\021\t \f\017\020\n\024\r\017\007\027\024\005 \022\017\001\022\ \017 )Tj 0.098 Tw T* (\017\n\036\035\017 \n\036\f\021\024 \r)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\001\035\024\n \017\035\017 \032\036 \r\t\016\r\035\016\035\017\ \f\034 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\023\024)Tj 0 Tw (-)Tj 0.095 Tw T* (\f\021\031\023\035\036\027\017\017 \017\035\017 \r)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\006\036\f\f\036 \024\002\f\035\036\007\024\r\026\027\017\016\ . \207\024\035\036\036 \004\036\n )Tj 0.034 Tw T* (\031)Tj /Span<>> BDC ( )Tj EMC (\023\024\035\024\r\017\027\t \023\026\006\017\036\027\021\024\r)Tj /Span<>> BDC ( )Tj EMC (\227 \r)Tj /Span<>> BDC ( )Tj EMC (25)Tj /Span<>> BDC ( )Tj EMC (\(53,2%\) \027\026\002\035\033\007\036\027\017\016\b, )Tj 0.227 Tw T* (\035\036\004\036\027\017\036 \026\r\024\030\024\021\026 \030\026\027\036\ \036 \024\f\031\013\036\f\021\r\035\016\035\024\f\034 \023\031\021\036\n\ \036\020\024 )Tj 0.284 Tw T* (\007\036\021\024\030\f\017\017 \035\026\023\026\030\024\021\024\n\027\t\n\ \007\024\f\021\031\023\024\n, \r)Tj /Span<>> BDC ( )Tj EMC (\030\016\007\036 \f\035\031\004\026\036\r )Tj 0.287 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\f\024\004\036\021\026\027\017\017 \f)Tj /Span<>> BDC ( )Tj EMC (\n\036\024\f\017\020\n\024\023\035\017\022\026\006\017\036\005. \200)Tj /Span<>> BDC ( )Tj EMC (15)Tj /Span<>> BDC ( )Tj EMC (\(31,9%\) )Tj 0.546 Tw T* (\f\035\031\004\026\016\b \r\t\023\024\035\027\016\035\026\f\034 \220\027\ \007\024\f\022\024\023\017\004\036\f\022\026\016 \007\036\021\024\030\f\017\ \016. )Tj 0.163 Tw T* (\215\030\017)Tj /Span<>> BDC ( )Tj EMC 2.016 0 Td [(\220\021\024\n )0.5(\031)]TJ /Span<>> BDC ( )Tj EMC 3.131 0 Td [(5 )0.5(\023\026\006\017\036\027\021\024\r )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC 6.445 0 Td [(\030\036\006\017\007\017\r\017\030\031\033\013\017\n\017 )0.6(\026\r\024)]TJ 0 Tw (-)Tj 0.073 Tw -11.593 -1.218 Td (\030\024\021\026\n\017 \024\027\026 \024\f\031\013\036\f\021\r\035\016\035\ \026\f\034 \022\026\022 \220\027\007\024\f\022\024\023\017\004\036\f\022\ \017, \021\026\022 )Tj 0.254 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\004\036\030\036 \035\026\023\026\030\024\021\024\n\017\033. \025\024\027\ \f\036\030\r\026\021\017\r\027\t\n\017 \n\036\021\024\007\026\n\017 )Tj 0.185 Tw T* (\035\017\022\r\017\007\017\030\024\r\026\021\034 \026\r\024\030\024\021\ \031\007\026\r\026\035\024\f\034 \031)Tj /Span<>> BDC ( )Tj EMC (12)Tj /Span<>> BDC ( )Tj EMC (\(25,5%\) \023\026)Tj 0 Tw (-)Tj 0.194 Tw T* (\006\017\036\027\021\024\r \(\230\026\002\035.)Tj /Span<>> BDC ( )Tj EMC (3\). \217\036\006\017\007\017\r \026\r\024\030\024\021\026 \023\024\f\035\ \036 \031\f\023\036\001)Tj 0 Tw (-)Tj 0.01 Tw T* (\027\024\005 \036\020\024 \007\036\021\024\030\f\017\017 \021\036\n \017\ \035\017 \017\027\t\n \f\023\024\f\024\002\024\n \017\n\036\035 \n\036\f\ \021\024 )Tj 0 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (26)Tj /Span<>> BDC ( )Tj EMC (\(55,3%\) \027\026\002\035\033\007\036\027\017\016\b.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 9 0 0 9 42.5197 730.483 Tm (\020\004\206\f\t\204\004 2.)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf ( \255\203\031\021\013\026 \027\032\031\003\031\021\025 \024\032\026\021\016\ \025\024\026 \033\n)Tj /Span<>> BDC ( )Tj EMC (\241\222\220 \027)Tj /Span<>> BDC ( )Tj EMC (\005\026\023\023\026\004)Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 0 -1.2 TD [(T)48(able 2)16(.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf ( Estimation of gut transit time in points)Tj ET 0 0 0 1 K 0.5 w /GS2 gs q 1 0 0 1 42.5197 715.181 cm 0 0 m 141.982 0 l S Q q 1 0 0 1 42.7697 703.9618 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 184.502 715.181 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 184.502 703.9618 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 246.8642 715.181 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 246.8642 703.9618 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 309.2264 715.181 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 309.2264 703.9618 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 371.5886 715.181 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 371.5886 703.9618 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 433.9508 715.181 cm 0 0 m 62.612 0 l S Q q 1 0 0 1 433.9508 703.9618 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 496.313 703.9618 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 42.5197 703.7118 cm 0 0 m 141.982 0 l S Q q 1 0 0 1 42.7697 692.5005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 184.502 703.7118 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 184.502 692.5005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 246.8642 703.7118 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 246.8642 692.5005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 309.2264 703.7118 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 309.2264 692.5005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 371.5886 703.7118 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 371.5886 692.5005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 433.9508 703.7118 cm 0 0 m 62.612 0 l S Q q 1 0 0 1 433.9508 692.5005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 692.5005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 692.2505 cm 0 0 m 141.982 0 l S Q q 1 0 0 1 184.502 692.2505 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 246.8642 692.2505 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 309.2264 692.2505 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 371.5886 692.2505 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 433.9508 692.2505 cm 0 0 m 62.612 0 l S Q BT /GS1 gs /T1_4 1 Tf 8 0 0 8 73.3806 706.5464 Tm (\026\006\r\214\235 \003\006\004\b\213\t\003\004 \(\201\004\217\013\))Tj 16.559 0 Td (\031\002 24)Tj 7.727 0 Td (24-48)Tj 7.795 0 Td (49-72)Tj 7.795 0 Td (73-96)Tj 7.104 0 Td (\225\002\f\r\r 96)Tj /T1_1 1 Tf -50.453 -1.433 Td (\207\026\035\035\t)Tj 21.01 0 Td (1)Tj 7.795 0 Td (2)Tj 7.795 0 Td (3)Tj 7.795 0 Td (4)Tj 7.795 0 Td (5)Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 9 0 0 9 42.5197 675.5312 Tm (\020\004\206\f\t\204\004 3.)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf ( \240\031\024\n\030\020 \023\031\006\031\021\025\002 \016\026\027\n\032\n\ \024\026 \027)Tj /Span<>> BDC ( )Tj EMC (\026\021\026\003\021\031\016\031)Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf T* [(T)48(able 3.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf [( T)56.1(reatment of sigmoid v)13.2(olvulus in the anamnesis)]TJ ET /GS2 gs q 1 0 0 1 42.5197 660.2293 cm 0 0 m 326.234 0 l S Q q 1 0 0 1 42.7697 649.0101 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 368.7539 660.2293 cm 0 0 m 127.809 0 l S Q q 1 0 0 1 368.7539 649.0101 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 496.313 649.0101 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 42.5197 648.7601 cm 0 0 m 326.234 0 l S Q q 1 0 0 1 42.7697 637.5488 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 368.7539 648.7601 cm 0 0 m 127.809 0 l S Q q 1 0 0 1 368.7539 637.5488 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 637.5488 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 637.2988 cm 0 0 m 326.234 0 l S Q q 1 0 0 1 42.7697 626.0875 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 368.7539 637.2988 cm 0 0 m 127.809 0 l S Q q 1 0 0 1 368.7539 626.0875 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 626.0875 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 625.8375 cm 0 0 m 326.234 0 l S Q q 1 0 0 1 42.7697 614.6262 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 368.7539 625.8375 cm 0 0 m 127.809 0 l S Q q 1 0 0 1 368.7539 614.6262 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 614.6262 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 614.3762 cm 0 0 m 326.234 0 l S Q q 1 0 0 1 42.7697 603.165 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 368.7539 614.3762 cm 0 0 m 127.809 0 l S Q q 1 0 0 1 368.7539 603.165 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 603.165 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 602.915 cm 0 0 m 326.234 0 l S Q q 1 0 0 1 42.7697 591.7037 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 368.7539 602.915 cm 0 0 m 127.809 0 l S Q q 1 0 0 1 368.7539 591.7037 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 591.7037 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 591.4537 cm 0 0 m 326.234 0 l S Q q 1 0 0 1 368.7539 591.4537 cm 0 0 m 127.809 0 l S Q BT /GS1 gs /T1_4 1 Tf 8 0 0 8 163.2144 651.5947 Tm (\215\r\003\002\240 \f\r\201\r\b\t\235 \213\004\002\006\002\003\004)Tj 27.893 0 Td (\030\t\217\f\002 \b\004\206\f\211\240\r\b\t\005, )Tj /T1_5 1 Tf (n)Tj /T1_4 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (47)Tj /T1_1 1 Tf -42.594 -1.433 Td (\214\026\023\026\030\024\021\024\n\017\016, \007\036\021\024\030\f\017\016\ \026\r\024\030\024\021\026)Tj 47.866 0 Td (14)Tj -47.866 -1.433 Td (\214\026\023\026\030\024\021\024\n\017\016, \007\036\021\024\030\f\017\016\ \026\r\024\030\024\021\026, \n\036\024\f\017\020\n\024\023\035\017\022\ \026\006\017\016)Tj 48.116 0 Td (6)Tj -48.116 -1.433 Td (\224\027\007\024\f\022\024\023\017\004\036\f\022\026\016 \007\036\021\024\ \030\f\017\016)Tj 47.866 0 Td (10)Tj -47.866 -1.433 Td (\214\026\023\026\030\024\021\024\n\017\016, \007\036\021\024\030\f\017\016\ \017)Tj /Span<>> BDC ( )Tj EMC (\220\027\007\024\f\022\024\023\017\004\036\f\022\026\016 \007\036\021\024\ \030\f\017\016 \(\023\030\017 \030\036\006\017\007\017\r\036 \026\r\024\ \030\024\021\026\))Tj 48.116 0 Td (5)Tj -48.116 -1.433 Td (\025\024\027\f\036\030\r\026\021\017\r\027\024\036 \035\036\004\036\027\017\ \036)Tj 47.866 0 Td (12)Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\033\030\031\030\213\b)-20.9(\035\231\213\233\t \021\032)50(\b)42(\032\231\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj /T1_6 1 Tf 25 0 0 25 512.7645 56.0378 Tm (35)Tj ET endstream endobj 2296 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.098 Tw 10 0 0 10 70.8661 724.8299 Tm (\215\030\017)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\n \007\026\032\036 \r)Tj /Span<>> BDC ( )Tj EMC (\002\035\026\020\024\023\030\017\016\021\027\024\005 \f\017\021\031\026\006\ \017\017 \031\f\023\036\001\027\024\005 )Tj -0.005 Tw 0 -1.218 TD (\220\027\007\024\f\022\024\023\017\004\036\f\022\024\005 \007\036\021\024\ \030\f\017\017 \026\r\024\030\024\021\026 \004\026\f\021\024\021\026 \030\ \036\006\017\007\017)Tj 0 Tw (-)Tj 0.064 Tw T* (\r\026 \f\024\f\021\026\r\035\016\036\021 45\22671% [11\22615]. \202)Tj /Span<>> BDC ( )Tj EMC (\035\036\021\026\035\034\027\024\f\021\034 \r)Tj /Span<>> BDC ( )Tj EMC (\f\035\031)Tj 0 Tw (-)Tj 0.028 Tw T* (\004\026\036 \022\024\027\f\036\030\r\026\021\017\r\027\024\020\024 \035\ \036\004\036\027\017\016 \f\024\b\030\026\027\016\036\021\f\016 \027\026\ )Tj /Span<>> BDC ( )Tj EMC (\031\030\024\r\027\036 )Tj 0 Tw T* (9\22636% [11\22615].)Tj 0.272 Tw T* (\200 \f\r\016\017 \f)Tj /Span<>> BDC ( )Tj EMC (\220\021\017\n, \f\024\020\035\026\f\027\024 \017)Tj /Span<>> BDC ( )Tj EMC [(\n\036\032\007\031\027\026\030\024\007\027\024\n\031 )0.5(\022\024\027)]TJ 0 Tw (-)Tj 0.12 Tw 0 -1.218 TD (\f\036\027\f\031\f\031 \023\024)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\021\017\022\036 \r\036\007\036\027\017\016 \026\r\024\030\024\ \021\024\r \f\017\020\n\024\r\017\007\027\024\005 )Tj 0.119 Tw 0 -1.218 TD [(\022\017\001\022\017 )0.5(2023 \020\024\007\026 [10], )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC (\023\030\036\007\t\007\031\013\017\n \030\036\022\024\n\036\027\007\026\006\ \017)Tj 0 Tw (-)Tj 0.106 Tw T* (\016\n 2016 \020\024\007\026 [1], \031\032\036 1 \026\r\024\030\024\021\ \r)Tj /Span<>> BDC ( )Tj EMC (\026\027\026\n\027\036\036 \016\r\035\016\036\021)Tj 0 Tw (-)Tj 0.065 Tw T* (\f\016 \f\021\030\024\020\017\n \023\024\022\026\026\027\017\036\n \022\ )Tj /Span<>> BDC ( )Tj EMC (\023\035\026\027\024\r\024\n\031 \b\017\030\031\030\020\017\004\036\f\022\ \024\n\031 )Tj 0.348 Tw T* [(\035\036\004\036\027\017\033, \026\022\035\033\004\026\033\013\036\n\031\ \f\016 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC [(\030\036\036\022\006\017\017 )0.5(\024\002\024\007\024\004\027\024\005 )]TJ 0.022 Tw T* (\022\017\001\022\017. \217\026\035\017\004\027\024\020\024 \030\024\007\ \026 \235\017\022\f\017\030\031\033\013\017\036 \024\023\036\030\026\006\ \017\017 \007\024)Tj 0 Tw (-)Tj 0 -1.218 TD (\022\026\026\035\017 \f\r\024\033 \027\036\220\235\235\036\022\021\017\r\ \027\024\f\021\034.)Tj 0.253 Tw 0 -1.218 TD (\204\036\020\026\022\024\035\024\027 \030\026\f\f\n\026\021\030\017\r\026\ \036\021\f\016 \022\026\022 \024\007\017\027 \017)Tj /Span<>> BDC ( )Tj EMC (\235\026\022\021\024\030\024\r )Tj 0.068 Tw 0 -1.218 TD (\030\017\f\022\026 \030\026\r\017\021\017\016 \026\r\024\030\024\021\026\ \f\017\020\n\024\r\017\007\027\024\005 \022\017\001\022\017 [2,16]. )Tj -0.004 Tw T* (\222)Tj /Span<>> BDC ( )Tj EMC (\007\036\005\f\021\r\017\021\036\035\034\027\024, \017\n\036\027\027\024\ \026\r\024\030\024\021 \016\r\035\016\036\021\f\016 \024\f\027\024\r\027\ \t\n )Tj 0.516 Tw T* [(\023\030\024\016\r\035\036\027\017\036\n )0.6(\024\f\035\024\032\027\036\027\027\024\020\024 )0.5(\021\036\004\036\027\017\016 )0.6(\017\007\017\024\023\026\021\017\004\036)]TJ 0 Tw (-)Tj 0.095 Tw T* (\f\022\024\020\024 \n\036\020\026\022\024\035\024\027. \202)Tj /Span<>> BDC ( )Tj EMC (\024\f\035\024\032\027\036\027\027\024\036 \021\036\004\036\027\017\036 \ \017\035\017 \r\t\f\024)Tj 0 Tw (-)Tj -0.004 Tw T* (\022\017\005 \036\020\024 \030\017\f\022, \r)Tj /Span<>> BDC ( )Tj EMC (\f\r\024\033 \024\004\036\030\036\007\034, \f\035\031\032\026\021 \024\f\ \027\024\r\027\t\n \023\024\022\026)Tj 0 Tw (-)Tj -0.045 Tw T* (\026\027\017\036\n \007\035\016 \023\035\026\027\024\r\024\020\024 \b\017\ \030\031\030\020\017\004\036\f\022\024\020\024 \r\n\036\001\026\021\036\035\ \034\f\021\r\026 )Tj -0.016 Tw T* (\031)Tj /Span<>> BDC ( )Tj EMC [(\021\026\022\024\020\024 \030\024\007\026 \023\026\006\017\036\027\021\024\ \r, \023\024\f\022\024\035\034\022\031 )0.5(\f\026\n )0.5(\023\024)]TJ /Span<>> BDC ( )Tj EMC [(\f\036\002\036 )0.5(\n\036\020\026)]TJ 0 Tw (-)Tj -0.009 Tw T* [(\022\024\035\024\027 )0.5(\031\020\030\024\t )0.5(\007\035\016 )0.6(\007\024\030\024\r\034\016 )0.5(\027\036 )0.5(\023\030\036\007\f\021\026\r\035\016\036\021. )0.6(\203\024 )0.5(\017\027\t\b )]TJ 0.264 Tw T* (\023\030\024\020\027\024\f\021\017\004\036\f\022\017\b \023\030\017\027\ \026\022\024\r, \023\024\r\024\035\016\033\013\017\005 \024\006\036\027\ \017\021\034 )Tj 0.286 Tw T* (\030\017\f\022 \026\r\024\030\024\021\026, \022\030\024\n\036 \235\026\022\ \021\026 \026\r\024\030\024\021\026 \r)Tj /Span<>> BDC ( )Tj EMC (\026\027\026\n\027\036\036, )Tj 0 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\007\024\f\021\031\023\027\024\005 \035\017\021\036\030\026\021\031\030\036\ \027\026\n \024\002\027\026\030\031\032\017\021\034 \027\036 \031\007\026\ \035\024\f\034.)Tj 0.11 Tw T* (\215\024\220\021\024\n\031 \006\036\035\034\033 \027\026\001\036\020\024\ \017\f\f\035\036\007\024\r\026\027\017\016 \f\021\026\035\026 \023\024\023\ \t\021\022\026 )Tj 0.101 Tw T* (\r\t\016\r\017\021\034 \235\026\022\021\024\030\t \030\017\f\022\026 \030\ \026\r\017\021\017\016 \026\r\024\030\024\021\024\r \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017)Tj 0 Tw (-)Tj 0.147 Tw T* (\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\017\007\017\024\023\026\021\017\004\036\f\022\017\n \n\036\020\026\022\024\ \035\024\027 \017)Tj /Span<>> BDC ( )Tj EMC (\027\026 \024\f\027\024\r\026\027\017\017 )Tj 0.094 Tw T* [(\220\021\024\020\024 )0.5(\031\021\024\004\027\017\021\034 )0.6(\023\024\022\026\026\027\017\016 )0.5(\007\035\016 )0.5(\023\035\026\027\024\r\024\020\024 )0.6(\b\017\030\031\030\020\017\004\036)]TJ 0 Tw (-)Tj T* (\f\022\024\020\024 \035\036\004\036\027\017\016.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0.01 Tc 0.018 Tw 14 0 0 14 70.936 335.1338 Tm [(\f\026\017\031\034\022\024\232)5( \031)5(\016)-18.3(\240\034)-31(\024)35(\037\226\232)]TJ 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0 Tc 0.769 Tw 10 0 0 10 70.8661 310.7778 Tm [(\204\026\021\036\030\017\026\035\024\n )0.6(\023\024\f\035\031\032\017\035 )0.5(\030\036\021\030\024\f\023\036\022\021\017\r\027\t\005 )0.6(\026\027\026\035\017 )]TJ 0.276 Tw T* [(\022\035\017\027\017\004\036\f\022\024\005 \022\026\030\021\017\027\t )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC [(\030\036\031\035\034\021\026\021\024\r )0.5(\024\002\f\035\036\007\024\r\026\027\017\016 )]TJ 0.407 Tw T* (151)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\026 \f)Tj /Span<>> BDC ( )Tj EMC (\017\007\017\024\023\026\021\017\004\036\f\022\017\n \n\036\020\026\022\024\ \035\024\027/\n\036\020\026)Tj 0 Tw (-)Tj 0.048 Tw T* (\030\036\022\021\031\n, \027\026\002\035\033\007\026\r\001\036\020\024\f\ \016 \r)Tj /Span<>> BDC ( )Tj EMC (\205\206\207\211 \253\203\204\222\037 \022\024\035\024\023\030\024\022\021\ \024)Tj 0 Tw (-)Tj 0.093 Tw T* (\035\024\020\017\017 \017\n\036\027\017 \202.\203.)Tj /Span<>> BDC ( )Tj EMC (\217\t\032\017\b\273 \204\017\027\007\030\026\r\026 \217\024\f\f\017\017\ \f)Tj /Span<>> BDC ( )Tj EMC (2002 )Tj 0.017 Tw T* (\023\024)Tj /Span<>> BDC ( )Tj EMC (2023 \020\020. \200)Tj /Span<>> BDC ( )Tj EMC (\017\f\f\035\036\007\024\r\026\027\017\036 \027\036 \r\022\035\033\004\026\ \035\017\f\034 \023\026\006\017\036\027\021\t, )Tj 0.238 Tw T* (\023\036\030\036\027\036\f\001\017\036 \007\024)Tj /Span<>> BDC ( )Tj EMC (\024\002\030\026\013\036\027\017\016 \r)Tj /Span<>> BDC ( )Tj EMC (\037\036\027\021\030 \024\002\f\021\030\031\022\021\017\r\027\t\036 )Tj 0.092 Tw T* (\030\036\036\022\006\017\017 \024\002\024\007\024\004\027\024\005 \022\017\ \001\022\017 \f)Tj /Span<>> BDC ( )Tj EMC (\235\024\030\n\017\030\024\r\026\027\017\036\n \022\024\035\024)Tj 0 Tw (-)Tj T* (\f\021\024\n\t, \r)Tj /Span<>> BDC ( )Tj EMC (\021\024\n \004\017\f\035\036 \023\024)Tj /Span<>> BDC ( )Tj EMC (\023\024\r\024\007\031 \026\r\024\030\024\021\024\r.)Tj 1.157 Tw T* (\212\017\026\020\027\024 \n\036\020\026\022\024\035\024\027/\n\036\020\026\ \030\036\022\021\031\n \031\f\021\026\027\026\r\035\017\r\026\035\f\016 \ )Tj 0.505 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC (\024\f\027\024\r\026\027\017\017 \030\036\027\021\020\036\027\022\024\027\ \021\030\026\f\021\027\024\020\024 \017\f\f\035\036\007\024\r\026\027\017\ \016 )Tj 0.071 Tw T* [(\(\017\030\030\017\020\024\f\022\024\023\017\017\), )0.5(\036\f\035\017 \001\017\030\017\027\026 )0.5(\021\024\020\024 \017\035\017 )0.5(\017\027\024\020\024 \024\021\007\036\035\026 )]TJ -0.027 Tw T* [(\021\024\035\f\021\024\005 )0.6(\022\017\001\022\017 )0.5(\023\030\036\r\t\001\026\035\026 )0.6(\023\026\030\026\n\036\021\030\t )0.5(\027\024\030\n\t, )0.6(\024\023\030\036\007\036)]TJ 0 Tw (-)Tj 0.032 Tw T* (\035\036\027\027\t\036 \r)Tj /Span<>> BDC ( )Tj EMC (\b\024\007\036 \030\036\027\021\020\036\027-\n\024\030\235\024\n\036\021\ \030\017\004\036\f\022\024\020\024 \017\f\f\035\036\007\024)Tj 0 Tw (-)Tj T* (\r\026\027\017\016 \(\230\026\002\035.)Tj /Span<>> BDC ( )Tj EMC (1\) [17].)Tj 0.17 Tw T* [(\207\024\035\036\027\034 )0.6(\206\017\030\001\023\030\031\027\020\026 )0.5(\022\026\022 )0.5(\023\030\017\004\017\027\026 )0.6(\030\026\r\017\021\017\016 )0.5(\n\036\020\026\022\024)]TJ 0 Tw (-)Tj 0.111 Tw T* (\035\024\027/\n\036\020\026\030\036\022\021\031\n \002\t\035\026 \017\f\022\ \035\033\004\036\027\026 \027\026)Tj /Span<>> BDC ( )Tj EMC (\024\f\027\024\r\026\027\017\017 \007\026\027)Tj 0 Tw (-)Tj 0.041 Tw T* (\027\t\b \017\030\030\017\020\024\f\022\024\023\017\017 \()Tj /T1_2 1 Tf 0 Tw (n)Tj /T1_0 1 Tf 0.041 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (151\), \026\027\024\030\036\022\021\026\035\034\027\024\005 \n\026\027\024\ \n\036)Tj 0 Tw (-)Tj 0.008 Tw T* [(\021\030\017\017 )0.5(\()]TJ /T1_2 1 Tf 0 Tw (n)Tj /T1_0 1 Tf 0.008 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC [(151\) )0.5(\017, \023\030\017)]TJ /Span<>> BDC ( )Tj EMC 8.825 0 Td [(\027\036\024\002\b\024\007\017\n\024\f\021\017, \002\017\024\023\f\017\017\ )0.5(\f\021\036\027\022\017 )]TJ 0 Tw -8.825 -1.218 Td (\023\030\016\n\024\005 \022\017\001\022\017 \023\024)Tj /Span<>> BDC ( )Tj EMC (\221\r\036\027\f\024\027\031 \()Tj /T1_2 1 Tf (n)Tj /T1_0 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (24\).)Tj 0.029 Tw 23.244 51.148 Td [(\200 )0.5(\026\027\026\035\017\036 )0.6(\031\004\017\021\t\r\026\035\017\f\034 )0.5(\021\026\022\017\036 )0.6(\023\030\017\027\026\022\017, )0.6(\022\026\022 )0.5(\023\024\035, )0.5(\r\024)]TJ 0 Tw (-)Tj 0.003 Tw 0 -1.218 TD (\030\026\f\021 \017)Tj /Span<>> BDC ( )Tj EMC [(\f\035\036\007\031\033\013\017\036 )0.5(\f\017\n\023\021\024\n\t: )0.5(\027\026\035\017\004\017\036 )0.5(\017\035\017 \024\021\f\031\021\f\021\r\017\036 )]TJ 0.159 Tw 0 -1.218 TD (\026\023\024\030\024\r, \f\024\b\030\026\027\027\024\f\021\034 \f\026\n\ \024\f\021\024\016\021\036\035\034\027\024\020\024 \f\021\031\035\026 \017\ )Tj /Span<>> BDC ( )Tj EMC (\023\024)Tj 0 Tw (-)Tj 0.262 Tw T* (\t\r\024\r \022)Tj /Span<>> BDC ( )Tj EMC (\007\036\235\036\022\026\006\017\017, \004\026\f\021\024\021\026 \007\036\ \235\036\022\026\006\017\017, \f\017\n\023\021\024\n\t )Tj 0.008 Tw T* (\026\002\007\024\n\017\027\026\035\034\027\024\020\024 \007\017\f\022\024\ \n\235\024\030\021\026 \017)Tj /Span<>> BDC ( )Tj EMC (\026\021\030\031\007\027\036\027\017\005 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\007\036)Tj 0 Tw (-)Tj T* (\235\036\022\026\006\017\017, \022\026\035\024\n\026\026\027\017\036.)Tj 0.004 Tc 0.192 Tw T* (\211 97 \023\026\006\017\036\027\021\024\r \022\035\017\027\017\004\036\f\ \022\017\036 \023\030\024\016\r\035\036\027\017\016 \024\006\036\027\017\ \r\026)Tj 0 Tc 0 Tw (-)Tj 0.004 Tc 0.027 Tw T* (\035\017\f\034 \f)Tj /Span<>> BDC ( )Tj EMC (\023\024\n\024\013\034\033 \f\023\036\006\017\026\035\034\027\024\020\024\ \024\023\030\024\f\027\017\022\026 \f)Tj /Span<>> BDC ( )Tj EMC (\020\030\026\007\026\006\017)Tj 0 Tc 0 Tw (-)Tj 0.004 Tc 0.132 Tw T* (\036\005 \004\026\f\021\024\021\t-\r\t\030\026\032\036\027\027\024\f\021\ \017 \f\017\n\023\021\024\n\024\r. \224\021\024 \023\024\r\024\035\017)Tj 0 Tc 0 Tw (-)Tj 0.004 Tc 0.191 Tw T* [(\035\024 \023\030\024\r\036\f\021\017 \022\024\035\017\004\036\f\021\r\036\ \027\027\t\005 \026\027\026\035\017 \f\017\n\023\021\024\n\026\021\017\022\ \017)4( )]TJ 0.273 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\002\026\035\034\027\024\005 \001\022\026\035\036. \207\024\035\036\036 \ \023\024\007\030\024\002\027\024 \n\036\021\024\007\017\022\026 \023\024\ \007)Tj 0 Tc 0 Tw (-)Tj 0.004 Tc 0.189 Tw T* [(\f\004\036\021\026 )0.5(\002\t\035\026 )0.5(\024\023\017\f\026\027\026 )0.5(\027\026\n\017 )0.5(\030\026\027\036\036 )0.5([18]. )0.5(\230\026\022\017\n )0.5(\024\002\030\026)]TJ 0 Tc 0 Tw (-)Tj 0.004 Tc 0.194 Tw T* (\024\n, \r)Tj /Span<>> BDC ( )Tj EMC [(\002\026\035\035\034\027\024\005 \001\022\026\035\036 \024\006\036\027\017\ \r\026\035\026\f\034 \r\t\030\026\032\036\027\027\024\f\021\034)4( )]TJ 0.137 Tw T* (\023\024\022\026\026\021\036\035\036\005 \253\026\002\007\024\n\017\027\ \026\035\034\027\t\005 \007\017\f\022\024\n\235\024\030\021\273 \017)Tj /Span<>> BDC ( )Tj EMC (\253\030\026\f)Tj 0 Tc 0 Tw (-)Tj 0.004 Tc 0.126 Tw T* (\f\021\030\024\005\f\021\r\024 \007\036\235\036\022\026\006\017\017\273,\ \026)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\032\036 \007\035\017\021\036\035\034\027\024\f\021\034 \026\ \027\026\n)Tj 0 Tc 0 Tw (-)Tj 0.004 Tc 0.204 Tw T* (\027\036\026 \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\b\030\026\027\027\024\f\021\034 \023\024\t\r\024\r \022)Tj /Span<>> BDC ( )Tj EMC [(\007\036\235\036\022\026\006\017\017, \004\026\f\021\024\021\026)4( )]TJ 0.318 Tw T* (\f\026\n\024\f\021\024\016\021\036\035\034\027\024\020\024 \f\021\031\035\ \026 \017)Tj /Span<>> BDC ( )Tj EMC [(\004\026\f\021\024\021\026 \007\036\235\036\022\026\006\017\017 \002\036\ )4( )]TJ 0.281 Tw T* (\017\f\023\024\035\034\024\r\026\027\017\016 \022\035\017\n \017)Tj /Span<>> BDC ( )Tj EMC [(\f\035\026\002\017\021\036\035\034\027\t\b \023\030\036\023\026\030\026\021\ \024\r,)4( )]TJ -0.034 Tw T* (\r\t\030\026\032\036\027\027\024\f\021\034 \026\023\024\030\024\r \023\024\ )Tj /Span<>> BDC ( )Tj EMC [(\n\024\007\017\235\017\006\017\030\024\r\026\027\027\024\005 \001\022\026\ \035\036)4( )]TJ -0.004 Tw T* (\200\036\022\f\027\036\030\026.)Tj 0 Tc 0.049 Tw T* (\222 \024\002\255\036\022\021\017\r\027\t\b \n\036\021\024\007\024\r \007\ \017\026\020\027\024\f\021\017\022\017 \r)Tj /Span<>> BDC ( )Tj EMC (\026\027\026\035\017 \002\t\035\017 )Tj 0.29 Tw T* (\r\022\035\033\004\036\027\t \030\036\031\035\034\021\026\021\t \017\030\ \030\017\020\024\f\022\024\023\017\017, \017\f\f\035\036\007\024\r\026\027\ \017\016 )Tj 0.076 Tw T* [(\021\030\026\027\017\021\026 \002\026\030\017\036\r\024\005 \r\r\036\f\ \017 )0.5(\023\024)]TJ /Span<>> BDC ( )Tj EMC (\032\036\035\031\007\024\004\027\024-\022\017\001\036\004\027\024\n\031 \ )Tj 0.308 Tw T* (\021\030\026\022\021\031 \(\240\025\230\), \030\036\027\021\020\036\027\024\ \r\f\022\024\005 \007\036\235\036\022\024\020\030\026\235\017\017 \017)Tj /Span<>> BDC ( )Tj EMC (\017\f)Tj 0 Tw (-)Tj 0.243 Tw T* (\f\035\036\007\024\r\026\027\017\016 \030\036\036\030\r\031\026\030\027\ \024\005 \235\031\027\022\006\017\017 \023\030\016\n\024\005 \022\017\001\ \022\017. )Tj 0.349 Tw T* (\222\f\023\024\035\034\024\r\026\035\017\f\034 \f\035\036\007\031\033\013\ \017\036 \023\024\022\026\026\021\036\035\017 \031\022\026\026\027\027\ \t\b )Tj 0 Tw T* (\007\017\026\020\027\024\f\021\017\004\036\f\022\017\b \021\036\f\021\024\ \r:)Tj T* (\243)Tj /Span<>> BDC ( )Tj EMC 1 0 Td (\222\030\030\017\020\024\f\022\024\023\017\016 \()Tj /T1_2 1 Tf (n)Tj /T1_0 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (151\))Tj ET q 0 0 566.929 793.701 re W n 0 0 0 1 K 4 M q 1 0 0 1 306.7551 252.7678 cm 0 0 m 0 0.8 -0.648 1.456 -1.448 1.456 c -2.248 1.456 -2.896 0.8 -2.896 0 c -2.896 -0.8 -2.248 -1.44 -1.448 -1.44 c -0.648 -1.44 0 -0.8 0 0 c h S Q Q BT 0 0 0 0 k /GS0 gs /T1_0 1 Tf 8 0 0 8 303.3071 249.8878 Tm (\243)Tj 0 0 0 1 k /GS1 gs /Span<>> BDC 10 0 0 10 307.3071 249.8878 Tm [( )-267( )]TJ EMC 0.5 0 Td (\234\017\030\017\027\026 \023\030\016\n\024\005 \022\017\001\022\017;)Tj ET q 0 0 566.929 793.701 re W n 0 0 0 1 K 4 M q 1 0 0 1 306.7551 240.5898 cm 0 0 m 0 0.8 -0.648 1.456 -1.448 1.456 c -2.248 1.456 -2.896 0.8 -2.896 0 c -2.896 -0.8 -2.248 -1.44 -1.448 -1.44 c -0.648 -1.44 0 -0.8 0 0 c h S Q Q BT 0 0 0 0 k /GS0 gs /T1_0 1 Tf 8 0 0 8 303.3071 237.7098 Tm (\243)Tj 0 0 0 1 k /GS1 gs /Span<>> BDC 10 0 0 10 307.3071 237.7098 Tm [( )-267( )]TJ EMC 0.5 0 Td (\212\035\017\027\026 \f\017\020\n\024\r\017\007\027\024\005 \022\017\001\ \022\017;)Tj ET q 0 0 566.929 793.701 re W n 0 0 0 1 K 4 M q 1 0 0 1 306.7551 228.4118 cm 0 0 m 0 0.8 -0.648 1.456 -1.448 1.456 c -2.248 1.456 -2.896 0.8 -2.896 0 c -2.896 -0.8 -2.248 -1.44 -1.448 -1.44 c -0.648 -1.44 0 -0.8 0 0 c h S Q Q BT 0 0 0 0 k /GS0 gs /T1_0 1 Tf 8 0 0 8 303.3071 225.5318 Tm (\243)Tj 0 0 0 1 k /GS1 gs /Span<>> BDC 10 0 0 10 307.3071 225.5318 Tm [( )-267( )]TJ EMC 0.5 0 Td (\234\017\030\017\027\026 \f\017\020\n\024\r\017\007\027\024\005 \022\017\ \001\022\017;)Tj ET q 0 0 566.929 793.701 re W n 0 0 0 1 K 4 M q 1 0 0 1 306.7551 216.2338 cm 0 0 m 0 0.8 -0.648 1.456 -1.448 1.456 c -2.248 1.456 -2.896 0.8 -2.896 0 c -2.896 -0.8 -2.248 -1.44 -1.448 -1.44 c -0.648 -1.44 0 -0.8 0 0 c h S Q Q BT 0 0 0 0 k /GS0 gs /T1_0 1 Tf 8 0 0 8 303.3071 213.3538 Tm (\243)Tj 0 0 0 1 k /GS1 gs /Span<>> BDC 10 0 0 10 307.3071 213.3538 Tm [( )-267( )]TJ EMC 0.5 0 Td (\234\017\030\017\027\026 \023\024\023\036\030\036\004\027\024\005 \024\002\ \024\007\024\004\027\024\005 \022\017\001\022\017;)Tj ET q 0 0 566.929 793.701 re W n 0 0 0 1 K 4 M q 1 0 0 1 306.7551 204.0558 cm 0 0 m 0 0.8 -0.648 1.456 -1.448 1.456 c -2.248 1.456 -2.896 0.8 -2.896 0 c -2.896 -0.8 -2.248 -1.44 -1.448 -1.44 c -0.648 -1.44 0 -0.8 0 0 c h S Q Q BT 0 0 0 0 k /GS0 gs /T1_0 1 Tf 8 0 0 8 303.3071 201.1758 Tm (\243)Tj 0 0 0 1 k /GS1 gs /Span<>> BDC 10 0 0 10 307.3071 201.1758 Tm [( )-267( )]TJ EMC 0.5 0 Td (\234\017\030\017\027\026 \r\024\f\b\024\007\016\013\036\005 \024\002\024\ \007\024\004\027\024\005 \022\017\001\022\017.)Tj 0.365 Tw -0.9 -1.218 Td (\200 \026\027\026\035\017\036 \031\004\017\021\t\r\026\035\f\016 \n\026\ \022\f\017\n\026\035\034\027\t\005 \023\024\023\036\030\036\004\027\t\005\ )Tj 0.447 Tw T* (\030\026\n\036\030 \f\024\024\021\r\036\021\f\021\r\031\033\013\036\020\ \024 \024\021\007\036\035\026 \021\024\035\f\021\024\005 \022\017\001\022\ \017. )Tj 0.247 Tw 0 -1.218 TD (\215\030\017)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\n \027\036\024\002\b\024\007\017\n\024 \024\021\n\036\021\017\ \021\034, \004\021\024 \r)Tj /Span<>> BDC ( )Tj EMC (\f\017\035\031 \030\036\021\030\024)Tj 0 Tw (-)Tj 0.034 Tw 0 -1.218 TD [(\f\023\036\022\021\017\r\027\024\020\024 )0.6(\b\026\030\026\022\021\036\030\026 )0.5(\026\027\026\035\017\026, )0.5(\026)]TJ /Span<>> BDC ( )Tj EMC 14.298 0 Td [(\021\026\022\032\036 )0.5(\021\036\b\027\017\004\036\f\022\017\b )]TJ 0.201 Tw -14.298 -1.218 Td [(\021\030\031\007\027\024\f\021\036\005 \022\024\027\021\030\026\f\021\017\ \030\024\r\026\027\017\016 )0.5(\023\030\026\r\t\b )0.5(\024\021\007\036\035\024\r \024\002\024)]TJ 0 Tw (-)Tj 0.035 Tw 0 -1.218 TD (\007\024\004\027\024\005 \022\017\001\022\017 \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\n\036\020\026\022\024\035\024\027 \017)Tj /Span<>> BDC ( )Tj EMC (\027\026\035\024\032\036\027\017\016 )Tj 0.098 Tw 0 -1.218 TD (\023\036\021\036\035\034 \022\017\001\022\017 \027\026)Tj /Span<>> BDC ( )Tj EMC (\017\030\030\017\020\024\020\030\026\n\n\026\b, \027\036 \r\024 \r\f\036\ \b \f\035\031\004\026\016\b )Tj 0.206 Tw 0 -1.218 TD [(\002\t\035\024 )0.5(\r\024\n\024\032\027\024 )0.6(\017\n\036\030\017\021\034 )0.5(\007\035\017\027\031 )0.6(\f\017\020\n\024\r\017\007\027\024\005 )0.5(\022\017\001)]TJ 0 Tw (-)Tj 0.185 Tw 0 -1.218 TD (\022\017 \017)Tj /Span<>> BDC ( )Tj EMC (\001\017\030\017\027\031 \023\024\023\036\030\036\004\027\024\005 \017)Tj /Span<>> BDC ( )Tj EMC (\r\024\f\b\024\007\016\013\036\005 \024\002\024\007\024\004\027\024\005 \ )Tj 0 Tw 0 -1.218 TD (\022\017\001\024\022.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf -0.025 Tw 9 0 0 9 303.3071 730.483 Tm (\020\004\206\f\t\204\004 1.)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf ( \231\025\032\025\021\026 \033\032\n\t\027\031\024\026 \032\026\016\023\025\ \006\021\020\004 \n\024\030\031\023\n\027 \024\n\023\t\024\n\017 )Tj 0 Tw 0 -1.2 TD (\013\025\001\013\025 \027)Tj /Span<>> BDC ( )Tj EMC (\021\n\032\003\031 \(n)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (160\) [17])Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf -0.029 Tw T* [(T)48(able 1)47(.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf [( The lumen width of the v)16(ar)-36.9(ious par)-40(ts of the larg)12(e intes)]TJ 0 Tw (-)Tj T* [(tine in nor)-13.9(mal \(n)]TJ /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (160\) [17])Tj ET 0 0 0 1 K 0.5 w /GS2 gs q 1 0 0 1 303.3071 693.5811 cm 0 0 m 110.551 0 l S Q q 1 0 0 1 303.5571 682.3618 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 413.8583 693.5811 cm 0 0 m 110.551 0 l S Q q 1 0 0 1 413.8583 682.3618 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 524.1594 682.3618 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 303.3071 682.1118 cm 0 0 m 110.551 0 l S Q q 1 0 0 1 303.5571 670.9006 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 413.8583 682.1118 cm 0 0 m 110.551 0 l S Q q 1 0 0 1 413.8583 670.9006 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.1594 670.9006 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 303.3071 670.6506 cm 0 0 m 110.551 0 l S Q q 1 0 0 1 303.5571 659.4393 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 413.8583 670.6506 cm 0 0 m 110.551 0 l S Q q 1 0 0 1 413.8583 659.4393 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.1594 659.4393 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 303.3071 659.1893 cm 0 0 m 110.551 0 l S Q q 1 0 0 1 303.5571 647.978 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 413.8583 659.1893 cm 0 0 m 110.551 0 l S Q q 1 0 0 1 413.8583 647.978 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.1594 647.978 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 303.3071 647.728 cm 0 0 m 110.551 0 l S Q q 1 0 0 1 303.5571 636.5167 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 413.8583 647.728 cm 0 0 m 110.551 0 l S Q q 1 0 0 1 413.8583 636.5167 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.1594 636.5167 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 303.3071 636.2667 cm 0 0 m 110.551 0 l S Q q 1 0 0 1 303.5571 625.0554 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 413.8583 636.2667 cm 0 0 m 110.551 0 l S Q q 1 0 0 1 413.8583 625.0554 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.1594 625.0554 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 303.3071 624.8054 cm 0 0 m 110.551 0 l S Q q 1 0 0 1 303.5571 613.5941 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 413.8583 624.8054 cm 0 0 m 110.551 0 l S Q q 1 0 0 1 413.8583 613.5941 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.1594 613.5941 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 303.3071 613.3441 cm 0 0 m 110.551 0 l S Q q 1 0 0 1 413.8583 613.3441 cm 0 0 m 110.551 0 l S Q BT /GS1 gs /T1_3 1 Tf 8 0 0 8 336.02 684.9465 Tm (\017\003\240\r\f \220\t\230\220\t)Tj 11.684 0 Td (\016\t\006\t\b\004 \212\006\002\217\r\003\004 \(\217\214\))Tj /T1_0 1 Tf -15.387 -1.433 Td (\221\035\036\023\026\016)Tj 18.864 0 Td (4,0\2269,0)Tj -18.864 -1.433 Td (\200\024\f\b\024\007\016\013\026\016)Tj 18.864 0 Td (2,5\2269,0)Tj -18.864 -1.433 Td (\215\024\023\036\030\036\004\027\026\016)Tj 18.864 0 Td (2,5\2268,5)Tj -18.864 -1.433 Td (\203\017\f\b\024\007\016\013\026\016)Tj 18.864 0 Td (1,5\2266,0)Tj -18.864 -1.433 Td (\221\017\020\n\024\r\017\007\027\026\016)Tj 18.864 0 Td (1,5\2266,0)Tj -18.864 -1.433 Td (\215\030\016\n\026\016)Tj 18.864 0 Td (4,5\2268,5)Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\033\030\031\030\213\b)-20.9(\035\231\213\233\t \021\032)50(\b)42(\032\231\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj -51.938 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 23, \023\0221)69(, 202)69(4)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 23, \023\0221)69(, 202)69(4)]TJ /T1_5 1 Tf 25 0 0 25 28.1776 56.0378 Tm (34)Tj ET endstream endobj 2295 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\210\013\n)-10(\026)11(\025\002\020 \002\220\006\n\013 \222\013\r\025\002\025\026)11(\013 \006\220\202)10(\024\025\r\220\201\001\025\203 \n\220\n\220 \215\022\221\013\227\220\016\ \001\026)11(\025\r )]TJ 0 -1 TD [(\006\022\220\201\220\025\221\013\026\220\017\016\006\n\220\024 \024\016\202\ )10.1(\013\n)10(\025\007\025\001/\024\016\202)10(\013\002\016\n)-9.9(\026)-20(\215\024)]TJ 33.279 1 Td [(Risk factor)20(s of sigmoid v)10(olv)10(ulus in patients with idiopathic megacolon)]TJ ET 0 0 0 1 K 1 j 1 J [0 2.997]0 d /GS1 gs q 1 0 0 1 46.0167 489.5757 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 43.0197 489.5757 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q [0 2.997]0 d q 1 0 0 1 46.0167 452.3678 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 43.0197 452.3678 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q 0 j 0 J q 1 0 0 1 42.5197 398.2986 cm 0 0 m 453.543 0 l S Q BT 0 0 0 1 k /T1_0 1 Tf 5.83 0 0 5.83 42.5197 733.048 Tm (2)Tj 0.023 Tw 10 0 0 10 45.8311 729.718 Tm [(Russian Medical Academ)21.1(y of Continuous Pr)20(ofessional Education \(Barrikadnay)21.1(a\022)-23.3(st., 2/1)69(, Moscow)22(, 1)125(2)23(5)23(99)35(3, )]TJ 0 Tw -0.331 -1.2 Td (Russia\))Tj /T1_1 1 Tf 0.023 Tw 9 0 0 9 90.7087 699.2141 Tm [(AIM: to identify r)-36.9(isk factors of sigmoid v)13(olvulus in patients with idiopathic meg)12(acolon/meg)12(arectum.)]TJ 0.157 Tw 0 -1.111 TD [(P)45(A)45(TIENT)-9.9(S A)53(ND METHODS: the retrospectiv)13(e study included 151 patients with idiopathic meg)11.9(acolon/meg)12(arectum )]TJ -0.016 Tw T* [(\(2002-2023\). The diagnosis of meg)12(acolon/meg)12.1(arectum w)13(as conf)-42.9(ir)-14(med with a bar)-37(ium enema. Hirschsp)46(rung\242)37(s disease )]TJ 0.023 Tw T* [(w)13(as e)-15(xcluded af)-46(ter anorectal manometr)-43(y and \(if needed\) rectal w)13(all biopsy by Sw)12(enson.)]TJ 0.037 Tw T* [(RESUL)30(T)-10(S: for)-40(ty)-14(-sev)13.1(en \(31.1%\) idiopathic meg)12(acolon/meg)12.1(arectum patients hav)13(e had sigmoid v)12.9(olvulus in histor)-43(y or )]TJ 0.042 Tw 0 -1.111 TD [(dur)-37(ing cur)-16(rent admission. In univ)16(ar)-36.9(iate analysis the signif)-43(icant cor)-16(relation w)13(as rev)13(ealed betw)12(een sigmoid v)13(olvulus )]TJ 0.121 Tw 0 -1.111 TD [(rate and ag)12(e, rate of defecation without assistance, rate of integ)14.1(ral parameter \236defecation dif)-39.9(f)-43(iculties\237, W)30(e)-15(xner )]TJ -0.009 Tw T* [(constipation )0.6(scale )0.5(rate )0.5(\(p)]TJ /Span<>> BDC ( )Tj EMC 10.181 0 Td (<)Tj /Span<>> BDC ( )Tj EMC 0.724 0 Td [(0.05\). )0.5(There )0.5(also )0.6(w)13(as )0.5(signif)-43(icant )0.5(cor)-15.9(relation )0.5(betw)12(een )0.5(sigmoid )0.5(v)13(olvulus )0.5(rate )0.5(and )0.5(sigmoid )]TJ 0.042 Tw -10.904 -1.111 Td [(length, )0.6(sigmoid )0.5(width, )0.5(rectum )0.6(width )0.6(and )0.5(rate )0.6(of )0.5(distal )0.6(retention )0.6(in )0.5(gut )0.6(transit )0.6(test )0.5(\(p)]TJ /Span<>> BDC ( )Tj EMC 33.817 0 Td (<)Tj /Span<>> BDC ( )Tj EMC 0.774 0 Td [(0.05\). )0.6(Due )0.5(to )0.6(multiv)16(ar)-37(iate )]TJ 0.036 Tw -34.591 -1.111 Td [(analysis \(multiple logistic reg)14(ression\) the best f)-43(it has the model, which sigmoid length, sigmoid width, and rectum )]TJ 0.054 Tw T* [(width w)12(ere included \(Somers)33.1(\242 D)]TJ /Span<>> BDC ( )Tj EMC (\227 0.867, KS statistic)Tj /Span<>> BDC ( )Tj EMC (\227 0.718, p)Tj /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (0.0001\). Sigmoid width \(OR)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (2.29; CI 1.38\226)Tj 0.026 Tw T* (3.82\) and rectum width \(OR)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC [(0.39; CI 0.22\2260,72\) w)12(ere independent factors af)-39.9(fected sigmoid v)13(olvulus rate. In the )]TJ -0.024 Tw T* [(R)19(OC analysis )0.5(the area under )0.5(the cur)-42(v)13(e w)13(as 0.93 with a )0.5(sensitivity of 82.4% and specif)-43(icity of 89.2% in Y)48(ouden)24(\242)36.9(s )0.5(point )]TJ 0.075 Tw T* [(of 0.719. The nomog)14(ram for sigmoid colon v)13(olvulus r)-37(isk p)46(rediction in idiopathic meg)12(acolon/meg)12(arectum patients )]TJ 0.023 Tw 0 -1.111 TD [(w)13(as build up based this model.)]TJ 0.087 Tw 0 -1.111 TD [(C)21(ON)22(CLUSION: idiopathic meg)12(acolon is associated with r)-36.9(isk of sigmoid v)13(olvulus. The r)-37(isk of sigmoid v)13(olvulus more )]TJ -0.011 Tw T* [(than )0.5(90% )0.5(estimated )0.5(with )0.5(the )0.5(nomog)14(ram )0.5(can )0.5(be )0.5(considered )0.5(as )0.5(a )0.5(reason )0.5(for )0.5(electiv)13(e )0.5(surg)12(er)-43(y )0.5(in )0.5(idiopathic meg)12(acolon/)]TJ 0.023 Tw T* [(meg)12(arectum patients without sigmoid v)13(olvulus in anamnesis.)]TJ /T1_2 1 Tf 0.01 Tc -0.01 Tw 8 0 0 8 42.5596 513.9449 Tm [(KEYW)22(ORDS:)]TJ /T1_1 1 Tf 0 Tc 0.023 Tw 4.948 0 Td [( Idiopathic meg)12(acolon, idiopathic meg)12(arectum, sigmoid v)13(olvulus)]TJ /T1_2 1 Tf 0.01 Tc 0.018 Tw -4.948 -1.909 Td [(C)19(ONFL)-33(ICT)5( OF)5( INTE)25(REST)62(:)]TJ /T1_1 1 Tf 0 Tc 0.023 Tw 9.871 0 Td [( The authors declare no conf)-22(lict of interest)]TJ /T1_2 1 Tf 0.037 Tc 0.093 Tw -9.871 -2.617 Td [(F)3.2(O)-4.6(R)8.7( C)-17.5(I)-15.6(T)45.5(A)37.5(T)-24.5(I)-1.3(ON:)]TJ /T1_3 1 Tf 0.023 Tc 0.102 Tw 6.538 0 Td [( A)-11.7(l)-23.7(e)-22.8(s)-8.8(h)-14(i)-3.2(n)]TJ /Span<>> BDC ( )Tj EMC [(D)16.3(.)40.6(V)39.8(.)-23.5(, A)-7.9(c)-10.2(h)-8.6(k)-24.2(a)-26.6(s)-19.1(o)-10.3(v)]TJ /Span<>> BDC ( )Tj EMC [(S)-9.6(.)-9.8(I)-10.3(.)-23.5(, S)-10.3(h)-8.3(a)-11.2(k)-16.8(h)-6.2(m)-8.3(a)-18.2(t)-21.9(o)-10.3(v)]TJ /Span<>> BDC ( )Tj EMC [(D)16.4(.)15(G)-11.6(.)-23.5(, F)-21(o)-9.2(m)-16.6(e)-11.5(n)-8.8(k)-3.7(o O)11.4(.)51.6(Y)12.6(u)-9(.)-23.4(, P)-0.9(o)-9.2(n)-11.9(o)-9.2(m)-8.3(a)-10.2(r)-19.1(e)-11.5(n)-8.8(k)-3.7(o)]TJ /Span<>> BDC ( )Tj EMC [(A)-23(.)-23.9(A)-23(.)-23.5(, I)-4.7(g)-8.8(n)-7.8(a)-18.2(t)-24.7(e)-11.5(n)-8.8(k)-3.7(o)]TJ /Span<>> BDC ( )Tj EMC [(M)-7.1(.)-23.9(A)-23(.)-23.5(, S)-12.1(u)-7.6(r)-15.8(o)-10.3(v)-18.7(e)-21(g)-28.9(i)-3.2(n)]TJ /Span<>> BDC ( )Tj EMC [(E)-5.5(.)-26.9(S)-9.6(.)-23.5(,)23( )]TJ -0.011 Tw -6.543 -1.2 Td [(S)-12.1(u)-21.9(s)-8.8(h)-8.6(k)-3.7(o)-10.3(v)]TJ /Span<>> BDC ( )Tj EMC [(O)11.4(.)-9.8(I)-10.3(. R)-26.1(i)-7.4(s)-11.1(k f)-39.2(a)-11.1(c)-41.5(t)-21.9(o)-11.8(r)-30.3(s o)-12.1(f s)-26.1(i)-6.8(g)-8.8(m)-12.4(o)-12.5(i)-8.8(d v)-15.4(o)-15.6(l)-5.6(v)-25.6(u)-8.4(l)-23.3(u)-21.9(s i)-3.2(n p)-20(a)-18.2(t)-46.2(i)-11(e)-11.4(n)-17.4(t)-48.9(s w)-45.7(i)-15.8(t)-26.1(h i)-8.8(d)-15.8(i)-6.8(o)-8.3(p)-20(a)-18.2(t)-26.1(h)-14(i)-5(c m)-16.6(e)-21(g)-8.1(a)-11.1(c)-6.5(o)-15.6(l)-20.9(o)-9.2(n)-5.6(. )]TJ /T1_1 1 Tf 0.033 Tc -0.033 Tw [(K)13.9(ol)3.6(op)2.5(r)3.1(o)3.4(k)-19.2(t)2.2(ol)3.7(o)-3.3(g)-13.2(i)6.7(a)5.8(.)]TJ /T1_3 1 Tf 0.013 Tc -0.001 Tw 43.824 0 Td [( 2)-18.9(0)-13.8(2)-1.2(4;2)-20.3(3)-4(\()27.7(1)34.3(\))4.6(:)-15.6(3)-4.4(2\226)-39(4)30.1(1)-5.8(.)-10.3( \()-10.9(i)-13.2(n)-10.3( R)-16.5(u)-31.9(s)-32.3(s)-25.5(.)33.2(\))0.5(.)13( )]TJ 0.023 Tc -0.023 Tw -43.824 -1.2 Td [(h)-17.2(t)-49.4(t)-29.4(p)-18.7(s)-8(:)1.9(/)84.7(/)36.4(d)-11.1(o)-12.5(i.)2.7(o)-11.8(r)-16.7(g)-22.8(/)11.2(1)14(0)6.5(.)-5.6(3)7.9(3)-15.9(8)1.3(7)4.6(8/)7.9(2)-8.9(0)9.3(7)-1.9(3)-13.3(-)41.2(7)10.7(55)-8.9(6)-26.7(-)9.7(2)-8.9(0)-3.8(2)8.8(4)-28.5(-)9.7(2)-10.3(3)-13.3(-)55.1(1)26.9(-)32.6(3)5.6(2)12.1(-)-30.3(4)40.1(1)]TJ /T1_2 1 Tf 0.01 Tc 0.053 Tw 0.005 -2.617 Td [(\026\020\021\033\030)5( \020\036\017)5( )0.5(\013\033\021\033\013\023\030\037\023:)]TJ /T1_1 1 Tf 0 Tc 0.058 Tw 10.646 0 Td [( \201\023\031\001\025\021 )0.5(\200\031\021\025\t \216\025\013\024\n\032\n\027\025\006, )0.5(\225\210\213\214 )0.5(\253\217\240\215\037 \013\n\023\n\033\032\n\013\024\n\023\n\202\025\025 \ \025\003\031\021\025 )0.5(\201.\217.)]TJ /Span<>> BDC ( )Tj EMC [(\212\020\204\025\004\273 \240\025\021\016\030\032\026\027\026 )0.5(\212\n\t\t\025\025, \205\023.)]TJ /Span<>> BDC ( )Tj EMC 43.127 0 Td (\207\026\023\002\003\026 )Tj 0.023 Tw -53.778 -1.2 Td (\201\030\025\023\002, \030.)Tj /Span<>> BDC ( )Tj EMC (2, \240\n\t\013\027\026, 123423, \212\n\t\t\025\002; \024\031\023. 8)Tj /Span<>> BDC ( )Tj EMC (\(499\)199-07-61; e-mail: aleshin_dv@gnck.ru)Tj /T1_2 1 Tf 0.01 Tc 0.123 Tw 0.005 -1.2 Td [(ADDRESS)5( )0.5(F)13(OR)5( )0.5(C)19(ORRESPONDEN)23(CE:)]TJ /T1_1 1 Tf 0 Tc 0.128 Tw 14.26 0 Td [( )0.5(Aleshin )0.6(D.V)61(., )0.5(Ryzhikh )0.6(N)18(ational )0.6(Medical )0.6(R)21(esearch )0.5(Center )0.6(of )0.5(Colop)46(roctology)42.1(, )0.5(Salyama )0.6(Adilya )0.6(st., )0.5(2, )0.5(Moscow)52.1(, )]TJ 0.023 Tw -14.265 -1.2 Td (123423, phone number: 8)Tj /Span<>> BDC ( )Tj EMC (\(499\)199-07-61; e-mail: aleshin_dv@gnck.ru)Tj 0 Tw 0 -2.792 TD (\200\026\024\026 \033\n\t\024\205\033\023\031\021\025\002)Tj /Span<>> BDC ( )Tj EMC (\227 21.11.2023)Tj /Span<>> BDC ( )Tj EMC 19.488 0 Td (\n\t\023\031 \030\n\032\026\005\n\024\013\025)Tj /Span<>> BDC ( )Tj EMC (\227 25.12.2023)Tj /Span<>> BDC ( )Tj EMC 18.78 0 Td (\032\025\021\002\024\n \013)Tj /Span<>> BDC ( )Tj EMC (\033\205\005\023\025\013\026\203\025\025)Tj /Span<>> BDC ( )Tj EMC (\227 12.02.2024)Tj ( )Tj -38.268 -1.375 Td (Received)Tj /Span<>> BDC ( )Tj EMC (\227 21.11.2023)Tj /Span<>> BDC ( )Tj EMC 19.488 0 Td (Revised)Tj /Span<>> BDC ( )Tj EMC (\227 25.12.2023)Tj /Span<>> BDC ( )Tj EMC 18.78 0 Td (Accepted for publication)Tj /Span<>> BDC ( )Tj EMC (\227 12.02.2024)Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 42.5896 335.1339 Tm (\023\023\034\226\034\022\031\034)Tj 0 0 0 1 k /GS1 gs /T1_3 1 Tf 0 Tc 0.046 Tw 10 0 0 10 42.5197 310.7779 Tm (\003\026\r\024\030\024\021 \021\024\035\f\021\024\005 \022\017\001\022\017\ )Tj /Span<>> BDC ( )Tj EMC (\227 \220\021\024 \023\024\r\024\030\024\021 \022\017\001\022\017 \r\024\ \022\030\031\020 )Tj 0.267 Tw 0 -1.218 TD (\024\f\017 \022\024\030\027\016 \036\201 \002\030\t\032\036\005\022\017 \ \(\n\036\036\027\021\036\030\017\026\035\034\027\024-\026\022\f\017\026\ \035\034)Tj 0 Tw (-)Tj 0.09 Tw T* (\027\t\005 \026\r\024\030\024\021\), \017\035\017 \r\024\022\030\031\020\ \024\f\017 \f\026\n\024\005 \022\017\001\022\017 \(\024\030\020\026\027\ \024-)Tj 0.123 Tw T* (\026\022\f\017\026\035\034\027\t\005 \026\r\024\030\024\021\) \017\035\017\ , \030\036\032\036, \023\024\023\036\030\036\022 \024\f\017 \022\017\001\ \022\017 )Tj 0.064 Tw T* [(\(\023\036\030\036\020\017\002, )0.5(\023\024\023\036\030\036\004\027\t\005 )0.6(\026\r\024\030\024\021\). )0.6(\003\026\r\024\030\024\021 )0.5(\022\017\001\022\017 )0.5(\023\030\017)]TJ 0 Tw (-)Tj 0.036 Tw T* (\r\024\007\017\021 \022)Tj /Span<>> BDC ( )Tj EMC (\030\026\r\017\021\017\033 \024\f\021\030\024\005 \022\017\001\036\004\027\ \024\005 \027\036\023\030\024\b\024\007\017\n\024\f\021\017, )Tj 0.053 Tw T* (\023\030\017\004\036\n \r)Tj /Span<>> BDC ( )Tj EMC (\026\r\017\f\017\n\024\f\021\017 \024\021 \f\021\036\023\036\027\017 \026\ \r\024\030\024\021\026 \027\036\023\030\024\b\024)Tj 0 Tw (-)Tj 0.083 Tw T* (\007\017\n\024\f\021\034 \n\024\032\036\021 \017\n\036\021\034 \235\024\030\ \n\031 \022\026\022 \024\002\021\031\030\026\006\017\024\027\027\024\005\ , \021\026\022 )Tj 0.015 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC [(\f\021\030\026\027\020\031\035\016\006\017\024\027\027\024\005. )0.5(\215\030\017)]TJ /Span<>> BDC ( )Tj EMC [(\026\r\024\030\024\021\036 )0.5(\027\026)]TJ /Span<>> BDC ( )Tj EMC (180)Tj 0 Tw (\260)Tj (\226270)Tj (\260)Tj 0.015 Tw /Span<>> BDC ( )Tj EMC (\027\026)Tj 0 Tw (-)Tj 0.236 Tw T* (\030\031\001\036\027\017\036 \022\030\024\r\024\f\027\026\002\032\036\027\ \017\016 \022\017\001\022\017, \022\026\022 \023\030\026\r\017\035\024, \ \n\036)Tj 0 Tw (-)Tj 0.145 Tw T* (\027\036\036 \r\t\030\026\032\036\027\024, \030\026\r\017\r\026\036\021\ \f\016 \023\024\007\027\036\036, \017)Tj /Span<>> BDC ( )Tj EMC (\022\035\017\027\017\004\036\f\022\026\016 )Tj 0.352 Tw T* (\022\026\030\021\017\027\026 \002\024\035\034\001\036 \f\024\024\021\r\036\ \021\f\021\r\031\036\021 \024\002\021\031\030\026\006\017\024\027\027\024\ \005 \027\036)Tj 0 Tw (-)Tj -0.026 Tw T* [(\023\030\024\b\024\007\017\n\024\f\021\017. )0.5(\215\030\017)]TJ /Span<>> BDC ( )Tj EMC [(\026\r\024\030\024\021\036 )0.5(\002\024\035\036\036 270)]TJ 0 Tw (\260)Tj -0.026 Tw [( )0.5(\017\001\036\n\017\016 \030\026)]TJ 0 Tw (-)Tj 0.163 Tw T* (\r\017\r\026\036\021\f\016 \f\021\030\036\n\017\021\036\035\034\027\036\036\ , \002\t\f\021\030\024 \023\030\017\r\024\007\016 \022)Tj /Span<>> BDC ( )Tj EMC (\027\036\022\030\024\031 )Tj 0.102 Tw T* (\022\017\001\036\004\027\024\005 \f\021\036\027\022\017, \023\036\030\235\ \024\030\026\006\017\017 \017)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\017\021\024\027\017\021\031, \f\024\023\030\024)Tj 0 Tw (-)Tj 0.001 Tw T* (\r\024\032\007\026\036\021\f\016 \002\031\030\027\024\005 \022\035\017\027\ \017\004\036\f\022\024\005 \f\017\n\023\021\024\n\026\021\017\022\024\005\ \017)Tj /Span<>> BDC ( )Tj EMC (\r\t)Tj 0 Tw (-)Tj 0.068 Tw T* (\f\024\022\017\n \030\017\f\022\024\n \027\036\002\035\026\020\024\023\030\ \017\016\021\027\024\020\024 \017\f\b\024\007\026. \223\026\013\036 \r\f\ \036\020\024 )Tj -0.027 Tw T* (\026\r\024\030\024\021\031 \023\024\007\r\036\030\020\026\036\021\f\016\ \f\017\020\n\024\r\017\007\027\026\016 \022\017\001\022\026)Tj /Span<>> BDC ( )Tj EMC (\227 \007\024)Tj /Span<>> BDC ( )Tj EMC (90% )Tj 0.103 Tw T* (\f\035\031\004\026\036\r. \200\021\024\030\t\n \023\024)Tj /Span<>> BDC ( )Tj EMC (\004\026\f\021\024\021\036, \b\024\021\016 \017)Tj /Span<>> BDC ( )Tj EMC (\027\026\004\017\021\036\035\034\027\024 \002\024)Tj 0 Tw (-)Tj 0.117 Tw T* (\035\036\036 \030\036\007\022\017\n, \016\r\035\016\036\021\f\016 \026\r\ \024\030\024\021 \f\035\036\023\024\005 \022\017\001\022\017, \021\024\004\ \027\036\036 )Tj 0.088 Tw 23.244 25.574 Td [(\020\024\r\024\030\016, \017\035\036\024\006\036\022\026\035\034\027\024\ \020\024 )0.5(\024\021\007\036\035\026 \022\017\001\036\004\027\017\022\026 \(5\22615%\ \). )]TJ 0.156 Tw T* (\203\026)Tj /Span<>> BDC ( )Tj EMC (\023\024\023\036\030\036\004\027\031\033 \024\002\024\007\024\004\027\031\ \033 \022\017\001\022\031 \017)Tj /Span<>> BDC ( )Tj EMC (\024\002\035\026\f\021\034 \035\036\r\024\020\024 )Tj 0 Tw T* (\017\020\017\002\026 \023\030\017\b\024\007\017\021\f\016 \027\036 \002\ \024\035\036\036 5% \027\026\002\035\033\007\036\027\017\005 [1].)Tj 0.402 Tw T* (\217\026\f\023\030\024\f\021\030\026\027\036\027\027\024\f\021\034 \026\ \r\024\030\024\021\026 \f\031\013\036\f\021\r\036\027\027\024 \030\026\035\ \017)Tj 0 Tw (-)Tj 0.461 Tw T* (\004\026\036\021\f\016 \020\036\024\020\030\026\235\017\004\036\f\022\017\ . \200)Tj /Span<>> BDC ( )Tj EMC (\253\220\027\007\036\n\017\004\027\t\b\273 \030\026\005\024\027\026\b, )Tj 0.078 Tw T* (\022)Tj /Span<>> BDC ( )Tj EMC (\022\026\022\017\n \024\021\027\024\f\017\021\f\016 \017)Tj /Span<>> BDC ( )Tj EMC (\217\024\f\f\017\016, \024\027\017 \f\024\f\021\026\r\035\016\033\021 \007\ \024)Tj /Span<>> BDC ( )Tj EMC (42% )Tj 0.013 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\f\021\030\031\022\021\031\030\036 \024\f\021\030\024\005 \022\017\001\036\ \004\027\024\005 \027\036\023\030\024\b\024\007\017\n\024\f\021\017 [2\226\ 5]. )Tj 0.046 Tw T* (\200)Tj /Span<>> BDC ( )Tj EMC (\021\024 \032\036 \r\030\036\n\016 \r)Tj /Span<>> BDC ( )Tj EMC (\221\234\202 \017)Tj /Span<>> BDC ( )Tj EMC (\026\023\026\007\027\t\b \f\021\030\026\027\026\b \004\026\f\021\024\021\ \026 \026)Tj 0 Tw (-)Tj 0.32 Tw T* [(\r\024\030\024\021\026 )0.5(\026\n\036\021\027\024 \n\036\027\034\001\036)]TJ /Span<>> BDC ( )Tj EMC 10.922 0 Td [(\227 )0.5(\023\024\030\016\007\022\026 10\22615% )0.5(\r\f\036\b )]TJ 0.126 Tw -10.922 -1.218 Td (\f\035\031\004\026\036\r \021\024\035\f\021\024\022\017\001\036\004\027\024\ \005 \027\036\023\030\024\b\024\007\017\n\024\f\021\017. \215\030\017)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\n )Tj 0.298 Tw T* (\r\024\030\026\f\021 \023\026\006\017\036\027\021\024\r, \022\026\022 \023\ \030\026\r\017\035\024, \002\024\035\034\001\036, \f)Tj /Span<>> BDC ( )Tj EMC (\023\017\022\024\n )Tj 0.477 Tw T* (\026\002\024\035\036\r\026\036\n\024\f\021\017 \027\026)Tj /Span<>> BDC ( )Tj EMC (6\2268-\005 \007\036\022\026\007\026\b \032\017\027\017 [6\2269]. )Tj 0.053 Tw T* (\003\026\022\024\027\024\n\036\030\027\024, \004\021\024 \027\026\004\017\ \021\036\035\034\027\026\016 \004\026\f\021\034 \002\024\035\034\027\t\b\ \022)Tj /Span<>> BDC ( )Tj EMC (\220\021\024)Tj 0 Tw (-)Tj -0.015 Tw T* (\n\031 \r\024\030\026\f\021\031 \017\n\036\036\021 \030\026\035\017\004\ \027\t\036 \f\024\023\031\021\f\021\r\031\033\013\017\036 \026\002\024\035\ \036)Tj 0 Tw (-)Tj 0.108 Tw T* (\r\026\027\017\016, \004\036\n \r\024 \n\027\024\020\024\n \017)Tj /Span<>> BDC ( )Tj EMC (\024\002\031\f\035\024\r\035\036\027 \f\024\b\030\026\027\016\033\013\017\ \005\f\016 )Tj 0 Tw T* (\r\t\f\024\022\017\005 \031\030\024\r\036\027\034 \035\036\021\026\035\034\ \027\024\f\021\017.)Tj 0.252 Tw T* [(\202\022\021\031\026\035\034\027\024\f\021\034 )0.5(\023\030\024\002\035\036\n\t \026\r\024\030\024\021\026 \024\023\030\036\ \007\036\035\016\036\021\f\016 \021\016)]TJ 0 Tw (-)Tj 0.106 Tw T* [(\032\036\f\021\034\033 )0.5(\024\f\035\024\032\027\036\027\017\005 )0.6(\220\021\024\020\024 )0.5(\f\024\f\021\024\016\027\017\016 )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC 16.783 0 Td (\f\022\035\024\027\027\024\f\021\034\033 )Tj 0.272 Tw -16.783 -1.218 Td (\022)Tj /Span<>> BDC ( )Tj EMC [(\030\036\006\017\007\017\r\017\030\024\r\026\027\017\033 )0.5(\023\030\017)]TJ /Span<>> BDC ( )Tj EMC (\022\024\027\f\036\030\r\026\021\017\r\027\024\n \023\024\007\b\024\007\036\ . )Tj 0.311 Tw T* (\230\026\022, \007\024)Tj /Span<>> BDC ( )Tj EMC (25% \023\026\006\017\036\027\021\024\r \031\032\036 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\023\024\f\021\031\023\035\036\027\017\017 \007\036)Tj 0 Tw (-)Tj 0.232 Tw T* [(\n\024\027\f\021\030\017\030\031\033\021 )0.6(\022\026\030\021\017\027\031 )0.5(\017\001\036\n\017\017 )0.5(\021\024\035\f\021\024\005 )0.6(\022\017\001\022\017, )0.5(\023\036\030)]TJ 0 Tw (-)Tj 0.239 Tw T* (\235\024\030\026\006\017\017, \023\036\030\017\021\024\027\017\021\026 \017\ \035\017 \f\036\023\021\017\004\036\f\022\024\020\024 \001\024\022\026 [\ 10]. )Tj ET 1 0.68 0 0.12 k /GS0 gs q 1 0 0 1 42.5197 707.7183 cm 0 0 m 0 0 l 0 -11.339 l 42.52 -11.339 l 42.52 0 l h f Q BT 0 0 0 0 k /T1_2 1 Tf 0 Tw 9 0 0 9 45.2263 698.791 Tm (ABSTRACT)Tj 1 0.68 0 0.12 k /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\033\030\031\030\213\b)-20.9(\035\231\213\233\t \021\032)50(\b)42(\032\231\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj /T1_5 1 Tf 25 0 0 25 512.8019 56.0378 Tm (33)Tj ET endstream endobj 2292 0 obj [2298 0 R] endobj 2293 0 obj <>stream q /GS0 gs /Fm0 Do Q 0 0 0 1 K 1 j 1 J [0 2.997]0 d /GS1 gs q 1 0 0 1 74.3631 248.741 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 71.3661 248.741 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q [0 2.997]0 d q 1 0 0 1 74.3631 211.5332 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 71.3661 211.5332 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q BT 0 0 0 1 k /T1_0 1 Tf 10 0 0 10 70.8661 724.8299 Tm (https://doi.org/10.33878/2073-7556-2024-23-1-32-41)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0.023 Tw 19 0 0 19 116.502 695.3259 Tm [(\210\013\n)-10(\026)11(\025\002\020 \002\220\006\n\013 \222\013\r\025\002\025\026)11(\013 \006\220\202)10(\024\025\r\220\201\001\025\203 \n\220\n\220 )]TJ -1.932 -1.105 Td [(\215\022)-23.3(\221\013\227\220\016\001\026)11(\025\r \006\022)-23.3(\220\201\220\025\221\013\026\220\017\016\006\n\220\024 \024\016\202)10(\013\n)10(\025\007\025\001/\024\016\202)10(\013\002\016\n)-10(\026)-20(\215\024)]TJ 0 0 0 1 k /GS1 gs 0 Tw 14 0 0 14 70.8661 649.822 Tm [(\b)-21(\007\016\220\001\022)-23.2(\255.\004.)]TJ 8.162 0 0 8.162 144.6071 654.484 Tm (1)Tj 0.023 Tw 14 0 0 14 149.2431 649.822 Tm [(, \b)20(\017\n\013\006\025\r\022)-23.2(\021.\030.)]TJ -0.069 Tc 0.069 Tw 8.162 0 0 8.162 234.9023 654.484 Tm [(1,)-69(2)]TJ 0 Tc 0.023 Tw 14 0 0 14 246.2229 649.822 Tm [(, \206\013\207\024\013\026)11.1(\025\r\022)-23.3(\255.\031)72(.)]TJ -0.069 Tc 0.069 Tw 8.162 0 0 8.162 340.5479 654.484 Tm [(1,)-69(2)]TJ 0 Tc 0.023 Tw 14 0 0 14 351.8685 649.822 Tm [(, \210\025\024\016\001\n)10.1(\025\022)-23.3(\036.\200.)]TJ 0 Tw 8.162 0 0 8.162 449.8756 654.484 Tm (1)Tj 14 0 0 14 454.5115 649.822 Tm (, )Tj -27.403 -1.143 Td [(\034\025\001\025\024\013\002\016\001\n)10.1(\025\022)-23.3(\b)-31(.\b)-31(.)]TJ 8.162 0 0 8.162 181.6927 638.484 Tm (1)Tj 0.023 Tw 14 0 0 14 186.3286 633.822 Tm [(, \030\202\001\013\026)11.1(\016\001\n)10(\025\022)-23.3(\005.\b)-31(.)]TJ 0 Tw 8.162 0 0 8.162 287.4992 638.484 Tm (1)Tj 0.023 Tw 14 0 0 14 292.1352 633.822 Tm [(, \021\215\002\025\r\016\202\220\001\022)-23.2(\t.\021.)]TJ 0 Tw 8.162 0 0 8.162 388.3781 638.484 Tm (1)Tj 0.023 Tw 14 0 0 14 393.0141 633.822 Tm [(, \021\215\n)10(\025\r\022)-23.2(\036.\030.)]TJ 0 Tw 8.162 0 0 8.162 477.6093 638.484 Tm (1)Tj 5.83 0 0 5.83 70.8661 619.4827 Tm (1)Tj 0.023 Tw 10 0 0 10 74.1775 616.1527 Tm [(\210\031\214)42(\240 \253\213\005\030\226 \n)10(\025\007\025\221\002\025\n)-9.9(\026)11(\025\007\025\202\220\220 \220\024\016\001\220 \b)-30.9(.\213.\022)-23.3(\033\020\217\220\207\273 \005\220\001\222\201\002\013\r\013 \033\025\006\ \006\220\220 \(\215\007.\022)-23.3(\021\013\007\205\024\013 \b)-20.9(\201\220\007\205, \201.\022)-23.3(2, \202)62.1(.\022)-23.3(\005\025\006\n\r\013, )]TJ -0.331 -1.2 Td [(1)125(23)58(423, \033\025\006\006\220\205\))]TJ 0 Tw ( )Tj 5.83 0 0 5.83 70.8661 595.4827 Tm (2)Tj 0.023 Tw 10 0 0 10 74.1775 592.1527 Tm [(\210\031\214)21(\036)20(\240 \255\034\036 \033)21(\005\b\213\034\036 \005\220\001\222\201\002\013\r\013 \033\025\006\006\220\ \220 \(\215\007.\022)-23.2(\214\013\002\002\220\n\013\201\001\013\205, \201.\022)-23.3(2/1)69(, \006)-10(\026\002)-31(.\022)-23.3(1)69(, \202)62(.\022)-23.2(\005\025\006\n\r\013, 1)125(2)23(5)23(99)35(3, \033\025\006\006\220\205\))]TJ /T1_0 1 Tf 0.02 Tw 9 0 0 9 119.0551 573.6488 Tm (\037\036\035\034: \027\020\002\027\025\024\022 \f\026\013\024\n\032\020 \ \032\025\t\013\026 \032\026\016\027\025\024\025\002 \016\026\027\n\032\n\ \024\026 \205)Tj /Span<>> BDC ( )Tj EMC (\033\026\203\025\031\021\024\n\027 \t)Tj /Span<>> BDC ( )Tj EMC (\025\030\025\n\033\026\024\025\006\031\t\013\025\003 \003\031\202\026\013\ \n\023\n\021/\003\031\202\026\032\031\013\024\205\003 )Tj 0.023 Tw 0 -1.111 TD (\025)Tj /Span<>> BDC ( )Tj EMC (\021\026 \n\t\021\n\027\026\021\025\025 \r\024\n\202\n \205\024\n\006\021\ \025\024\022 \033\n\013\026\016\026\021\025\002 \030\023\002 \033\023\026\ \021\n\027\n\202\n \004\025\032\205\032\202\025\006\031\t\013\n\202\n \023\ \031\006\031\021\025\002.)Tj 0.319 Tw T* (\201\037\215\036\217\220\235 \215)Tj /Span<>> BDC ( )Tj EMC (\240\036\220\255\200\235: \032\031\024\032\n\t\033\031\013\024\025\027\021\ \020\017 \026\021\026\023\025\016 \013\023\025\021\025\006\031\t\013\n\017\ \013\026\032\024\025\021\020 \025)Tj /Span<>> BDC ( )Tj EMC (\032\031\016\205\023\022\024\026\024\n\027 \n\005\t\023\031\030\n\027\026\ \021\025\002 )Tj 0.024 Tw T* (151)Tj /Span<>> BDC ( )Tj EMC (\033\026\203\025\031\021\024\026 \t)Tj /Span<>> BDC ( )Tj EMC (\025\030\025\n\033\026\024\025\006\031\t\013\025\003 \003\031\202\026\013\ \n\023\n\021/\003\031\202\026\032\031\013\024\205\003, \021\026\005\023\007\ \030\026\027\001\031\202\n\t\002 \027)Tj /Span<>> BDC ( )Tj EMC (\225\210\213\214 \253\217\240\215\037 \013\n\023\n\033\032\n\013\024\n\023\ \n\202\025\025 )Tj 0.015 Tw T* (\025\003\031\021\025 \201.\217.)Tj /Span<>> BDC ( )Tj EMC (\212\020\204\025\004\273 \240\025\021\016\030\032\026\027\026 \212\n\t\t\ \025\025 \t)Tj /Span<>> BDC ( )Tj EMC (2002 \033\n)Tj /Span<>> BDC ( )Tj EMC (2023 \202\n\030. \217\026\023\025\006\025\031 \003\031\202\026\013\n\023\ \n\021/\003\031\202\026\032\031\013\024\205\003 \205\t\024\026\021\026\027\ \023\025\027\026\023\n\t\022 )Tj 0.046 Tw 0 -1.111 TD (\033\n)Tj /Span<>> BDC ( )Tj EMC (\032\031\016\205\023\022\024\026\024\026\003 \032\031\021\024\202\031\021\ \n\013\n\021\024\032\026\t\024\021\n\202\n \025\t\t\023\031\030\n\027\026\ \021\025\002. \213\n\023\031\016\021\022 \210\025\032\001\033\032\205\021\ \202\026 \005\020\023\026 \025\t\013\023\007\006\031\021\026 \021\026)Tj /Span<>> BDC ( )Tj EMC (\n\t\021\n\027\026\021\025\025 )Tj 0.028 Tw 0 -1.111 TD [(\026\021\026\023\025\016\026 \032\031\021\024\202\031\021\n\023\n\202\025\ \006\031\t\013\n\017 )0.5(\013\026\032\024\025\021\020 \025)]TJ /Span<>> BDC ( )Tj EMC (\026\021\n\032\031\013\024\026\023\022\021\n\017 \003\026\021\n\003\031\024\ \032\025\025, \033\032\025)Tj /Span<>> BDC ( )Tj EMC (\021\031\n\005\004\n\030\025\003\n\t\024\025)Tj /Span<>> BDC ( )Tj EMC (\227 \003\n\032\f\n\023\n\202\025\006\031)Tj 0 Tw (-)Tj 0.023 Tw T* (\t\013\n\202\n \025\t\t\023\031\030\n\027\026\021\025\002 \005\025\n\033\ \024\026\024\026 \t\024\031\021\013\025 \033\032\002\003\n\017 \013\025\001\ \013\025 \033\n)Tj /Span<>> BDC ( )Tj EMC (\207\027\031\021\t\n\021\205.)Tj -0.013 Tw T* [(\212\036\221\214\035\034\220\201\220\235: )0.5(\205)]TJ /Span<>> BDC ( )Tj EMC 6.313 0 Td (47)Tj /Span<>> BDC ( )Tj EMC 1.22 0 Td [(\(31,1%\) )0.5(\025\016)]TJ /Span<>> BDC ( )Tj EMC 4.659 0 Td [(151 )0.5(\033\026\203\025\031\021\024\026 )0.5(\t)]TJ /Span<>> BDC ( )Tj EMC [(\025\030\025\n\033\026\024\025\006\031\t\013\025\003 )0.6(\003\031\202\026\013\n\023\n\021/\003\031\202\026\032\031\013\024\205\003\ \016\026\027\n\032\n\024 )0.5(\t\025\202\003\n\027\025\030\021\n\017 )]TJ 0.034 Tw -12.192 -1.111 Td (\013\025\001\013\025 \025\003\031\023 \003\031\t\024\n \027)Tj /Span<>> BDC ( )Tj EMC (\033\032\n\001\023\n\003 \025\023\025 \204\031 \027\020\002\027\023\002\023\ \t\002 \033\032\025)Tj /Span<>> BDC ( )Tj EMC (\033\n\t\024\205\033\023\031\021\025\025 \025\023\025 \027)Tj /Span<>> BDC ( )Tj EMC (\033\032\n\203\031\t\t\031 \n\005\t\023\031\030\n\027\026\021\025\002. \ \032\025)Tj /Span<>> BDC ( )Tj EMC (\205\021\025\027\026)Tj 0 Tw (-)Tj -0.013 Tw T* (\032\025\026\021\024\021\n\003 \026\021\026\023\025\016\031 \013\023\025\ \021\025\006\031\t\013\025\003\025 \033\032\025\016\021\026\013\026\003\025\ , \t\024\026\024\025\t\024\025\006\031\t\013\025 \016\021\026\006\025\003\ \n \013\n\032\032\031\023\025\032\205\007\211\025\003\025 \t)Tj /Span<>> BDC ( )Tj EMC (\032\025\t\013\n\003 \016\026\027\n\032\n\024\026, )Tj 0.294 Tw T* (\002\027\023\002\007\024\t\002 \027\n\016\032\026\t\024, \006\026\t\024\n\ \024\026 \t\026\003\n\t\024\n\002\024\031\023\022\021\n\017 \030\031\f\031\ \013\026\203\025\025, \027\020\032\026\204\031\021\021\n\t\024\022 \033\n\ \013\026\016\026\024\031\023\002 \253\032\026\t\t\024\032\n\017\t\024\027\ \n )Tj 0.234 Tw T* [(\030\031\f\031\013\026\203\025\025\273 )0.6(\025)]TJ /Span<>> BDC ( )Tj EMC 6.433 0 Td [(\025\021\024\031\021\t\025\027\021\n\t\024\022 )0.7(\016\026\033\n\032\n\027 )0.6(\033\n)]TJ /Span<>> BDC ( )Tj EMC 12.227 0 Td [(\001\013\026\023\031 )0.6(\216\031\013\t\021\031\032\026. )0.6(\200\025\026\202\021\n\t\024\025\006\031\t\013\025\003\025 )0.6(\033\032\025\016\021\026\013\026\003\025, )0.5(\030\n\t\024\n\027\031\032\021\n )]TJ 0.235 Tw -18.66 -1.111 Td (\026\t\t\n\203\025\025\032\n\027\026\021\021\020\003\025 \t)Tj /Span<>> BDC ( )Tj EMC (\032\025\t\013\n\003 \016\026\027\n\032\n\024\026, \002\027\023\002\007\024\ \t\002 \030\023\025\021\026 \025)Tj /Span<>> BDC ( )Tj EMC (\001\025\032\025\021\026 \t\025\202\003\n\027\025\030\021\n\017 \013\025\ \001\013\025, \001\025\032\025\021\026 \033\032\002\003\n\017 )Tj 0.051 Tw 0 -1.111 TD (\013\025\001\013\025, \030\025\t\024\026\023\022\021\026\002 \016\026\030\ \031\032\204\013\026 \013\n\021\024\032\026\t\024\026 \033\032\025)Tj /Span<>> BDC ( )Tj EMC (\025\t\t\023\031\030\n\027\026\021\025\025 \024\032\026\021\016\025\024\026\ \033\n)Tj /Span<>> BDC ( )Tj EMC (\241\222\220. \207\n\202\023\026\t\021\n \003\021\n\202\n\f\026\013\024\n\ \032\021\n\003\205 )Tj 0.043 Tw 0 -1.111 TD (\023\n\202\025\t\024\025\006\031\t\013\n\003\205 \032\031\202\032\031\t\t\ \025\n\021\021\n\003\205 \026\021\026\023\025\016\205, \021\026\025\023\205\ \006\001\025\003\025 \004\026\032\026\013\024\031\032\025\t\024\025\013\026\ \003\025 \t)Tj /Span<>> BDC ( )Tj EMC (\024\n\006\013\025 \016\032\031\021\025\002 \t\024\026\024\025\t\024\025\ \006\031\t\013\n\017 )Tj 0.051 Tw T* (\016\021\026\006\025\003\n\t\024\025 \025)Tj /Span<>> BDC ( )Tj EMC [(\033\032\n\202\021\n\t\024\025\006\031\t\013\n\017 )0.5(\t\033\n\t\n\005\021\n\t\024\025 \n\005\023\026\030\026\023\026 \003\n\030\ \031\023\022, )0.5(\027)]TJ /Span<>> BDC ( )Tj EMC (\013\n\024\n\032\205\007 \005\020\023\025 \027\013\023\007\006\031\021\020\ \024\n\023\022\013\n \032\026\016\003\031\032\020 )Tj 0.034 Tw T* (\013\025\001\n\013 \033\n)Tj /Span<>> BDC ( )Tj EMC [(\030\026\021\021\020\003 )0.5(\025\032\032\025\202\n\t\013\n\033\025\025)]TJ /Span<>> BDC ( )Tj EMC 13.505 0 Td (\227 \030\023\025\021\026 \025)Tj /Span<>> BDC ( )Tj EMC [(\001\025\032\025\021\026 )0.5(\t\025\202\003\n\027\025\030\021\n\017 )0.5(\013\025\001\013\025, \025)]TJ /Span<>> BDC ( )Tj EMC (\001\025\032\025\021\026 \033\032\002\003\n\017 \013\025\001\013\025. \032\ \025)Tj /Span<>> BDC ( )Tj EMC (\r\024\n\003 )Tj 0.16 Tw -13.505 -1.111 Td (\t\024\026\024\025\t\024\025\006\031\t\013\025 \016\021\026\006\025\003\020\ \003\025 \033\032\031\030\025\013\024\n\032\026\003\025 \002\027\023\002\ \023\025\t\022 \024\n\023\022\013\n \001\025\032\025\021\026 \t\025\202\003\ \n\027\025\030\021\n\017 \013\025\001\013\025 \(\255\231)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (2,29; \200\215 )Tj 0.029 Tw T* (1,38\2263,82\) \025)Tj /Span<>> BDC ( )Tj EMC (\001\025\032\025\021\026 \033\032\002\003\n\017 \013\025\001\013\025 \(\255\ \231)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,39; \200\215 0,22\2260,72\). \032\025)Tj /Span<>> BDC ( )Tj EMC (ROC-\026\021\026\023\025\016\031 \033\023\n\211\026\030\022 \033\n\030 \013\ \032\025\027\n\017 \t\n\t\024\026)Tj 0 Tw (-)Tj 0.062 Tw T* [(\027\025\023\026 0,93 \(\200\215 )0.5(0,87\2261,0; p)]TJ /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC [(0,001\); \027 \024\n\006\013\031 )0.5(\223\030\031\021\026 \033\032\025)]TJ /Span<>> BDC ( )Tj EMC 23.312 0 Td [(\016\021\026\006\031\021\025\025 )0.5(\f\205\021\013\203\025\025 0,719 \006\205\027\t\024\027\025\024\031\023\022\ \021\n\t\024\022 \003\n\030\031\023\025 )]TJ 0.132 Tw -23.312 -1.111 Td (\n\013\026\016\026\023\026\t\022 \032\026\027\021\026 82,4%, \026)Tj /Span<>> BDC ( )Tj EMC (\t\033\031\203\025\f\025\006\021\n\t\024\022)Tj /Span<>> BDC ( )Tj EMC (\227 89,5%. \217\026)Tj /Span<>> BDC ( )Tj EMC (\n\t\021\n\027\026\021\025\025 \030\026\021\021\n\017 \003\n\030\031\023\ \025 \033\n\t\024\032\n\031\021\026 \021\n\003\n\202\032\026\003\003\026\ )Tj 0.1 Tw T* (\033\032\n\202\021\n\016\025\032\n\027\026\021\025\002 \032\025\t\013\026\ \016\026\027\n\032\n\024\026 \t\025\202\003\n\027\025\030\021\n\017 \013\ \025\001\013\025 \205)Tj /Span<>> BDC ( )Tj EMC (\033\026\203\025\031\021\024\n\027 \t)Tj /Span<>> BDC ( )Tj EMC (\025\030\025\n\033\026\024\025\006\031\t\013\025\003 \003\031\202\026\013\ \n\023\n\021/\003\031\202\026\032\031\013)Tj 0 Tw (-)Tj 0.023 Tw 0 -1.111 TD (\024\205\003 \033\n)Tj /Span<>> BDC ( )Tj EMC (\032\026\016\003\031\032\026\003 \033\032\002\003\n\017 \025)Tj /Span<>> BDC ( )Tj EMC (\t\025\202\003\n\027\025\030\021\n\017 \013\025\001\n\013.)Tj 0.075 Tw 0 -1.111 TD (\221\201\222\035\223\224\036\217\215\036: \215\030\025\n\033\026\024\025\ \006\031\t\013\025\017 \003\031\202\026\013\n\023\n\021 \026\t\t\n\203\025\ \025\032\n\027\026\021 \t)Tj /Span<>> BDC ( )Tj EMC (\033\n\027\020\001\031\021\021\020\003 \032\025\t\013\n\003 \032\026\016\ \027\025\024\025\002 \016\026\027\n\032\n\024\026 \t\025\202\003\n)Tj 0 Tw (-)Tj 0.048 Tw T* (\027\025\030\021\n\017 \013\025\001\013\025. \212\025\t\013 \016\026\027\ \n\032\n\024\026 \005\n\023\031\031 90%, \n\203\031\021\031\021\021\020\017\ \033\n)Tj /Span<>> BDC ( )Tj EMC (\033\032\031\030\023\n\204\031\021\021\n\017 \021\n\003\n\202\032\026\003\ \003\031, \003\n\204\021\n \032\026\t\t\003\026\024\032\025\027\026\024\022\ )Tj 0.234 Tw T* [(\013\026\013 \033\n\013\026\016\026\021\025\031 )0.5(\013)]TJ /Span<>> BDC ( )Tj EMC [(\033\023\026\021\n\027\n\003\205 \004\025\032\205\032\202\025\006\031\t\013\ \n\003\205 )0.5(\027\003\031\001\026\024\031\023\022\t\024\027\205 )0.5(\205)]TJ /Span<>> BDC ( )Tj EMC (\033\026\203\025\031\021\024\n\027 \t)Tj /Span<>> BDC ( )Tj EMC (\025\030\025\n\033\026\024\025\006\031\t\013\025\003 \003\031\202\026\013\ \n\023\n\021 )Tj 0.023 Tw T* (\033\032\025)Tj /Span<>> BDC ( )Tj EMC (\n\024\t\205\024\t\024\027\025\025 \016\026\027\n\032\n\024\026 \027)Tj /Span<>> BDC ( )Tj EMC (\026\021\026\003\021\031\016\031.)Tj /T1_2 1 Tf 0.01 Tc 0.018 Tw 8 0 0 8 70.906 288.3795 Tm [(\037\036\035\034\033\032\031\033)5( \030\036\027\032\026:)]TJ /T1_0 1 Tf 0 Tc 0.023 Tw 8.493 0 Td ( \025\030\025\n\033\026\024\025\006\031\t\013\025\017 \003\031\202\026\013\ \n\023\n\021, \025\030\025\n\033\026\024\025\006\031\t\013\025\017 \003\031\ \202\026\032\031\013\024\205\003, \016\026\027\n\032\n\024 \t\025\202\003\ \n\027\025\030\021\n\017 \013\025\001\013\025)Tj /T1_2 1 Tf 0.01 Tc 0.018 Tw -8.493 -1.909 Td [(\037\027\025\024\036\023\037\022)5( \023\025\022\033\021\033\030\027\032:)]TJ /T1_0 1 Tf 0 Tc 0.023 Tw 10.401 0 Td ( \026\027\024\n\032\020 \016\026\002\027\023\002\007\024 \n\005 \n\024\t\ \205\024\t\024\027\025\025 \013\n\021\f\023\025\013\024\026 \025\021\024\ \031\032\031\t\n\027)Tj /T1_2 1 Tf 0.01 Tc -0.01 Tw -10.401 -1.909 Td (\024\023\025\026\025\030\023\021\027\032\026\025\023\033:)Tj /T1_0 1 Tf 0 Tc 0.023 Tw 8.655 0 Td ( \215\t\024\n\006\021\025\013\025 \f\025\021\026\021\t\025\032\n\027\026\ \021\025\002 \n\024\t\205\024\t\024\027\205\007\024)Tj /T1_2 1 Tf 0.033 Tc -0.002 Tw -8.655 -2.617 Td [(\020\036\017)4.7( )0.5(\016\023\022\023\021\027\032\026\025\023\017:)]TJ /T1_3 1 Tf 0.023 Tc 0.003 Tw 9.17 0 Td [( )0.5(\202\035\036\001\017\027)]TJ /Span<>> BDC ( )Tj EMC 3.852 0 Td [(\212.\200., )0.5(\202\004\022\026\f\024\r)]TJ /Span<>> BDC ( )Tj EMC 6.075 0 Td [(\221.\222., )0.5(\234\026\b\n\026\021\024\r)]TJ /Span<>> BDC ( )Tj EMC 6.801 0 Td [(\212.\206., )0.5(\205\024\n\036\027\022\024)]TJ /Span<>> BDC ( )Tj EMC (\210.\236., \215\024\027\024\n\026\030\036\027\022\024)Tj /Span<>> BDC ( )Tj EMC 14.858 0 Td [(\202.\202., )0.5(\222\020\027\026\021\036\027\022\024)]TJ /Span<>> BDC ( )Tj EMC 7.017 0 Td [(\204.\202., )0.5(\221\031\030\024\r\036\020\017\027)]TJ /Span<>> BDC ( )Tj EMC 7.095 0 Td [(\213.\221.,)23( )]TJ 0.02 Tc -0.035 Tw -54.873 -1.2 Td [(\221)0.5(\031)0.5(\001)0.5(\022\024)0.5(\r)]TJ /Span<>> BDC 3.134 0 Td ( )Tj EMC [(\210)0.5(.)0.5(\222)0.5(.)0.5( \205)0.5(\026)0.5(\022)0.5(\021)0.5(\024)0.5(\030)0.5(\t )0.5(\030)0.5(\017)0.5(\f\022)0.5(\026)0.5( )0.5()0.5(\026\r)0.5(\024)0.5(\030)0.5(\024)0.5(\021)0.5(\026)0.5( \f)0.5(\017)0.5(\020)0.5(\n\024)0.5(\r)0.5(\017)0.5(\007)0.5(\027)0.5(\024)0.5(\005)0.5( \022)0.5(\017)0.5(\001)0.5(\022)0.5(\017 )0.5(\031)]TJ /Span<>> BDC 22.228 0 Td ( )Tj EMC [(\023)0.5(\026)0.5(\006)0.5(\017)0.5(\036)0.5(\027)0.5(\021)0.5(\024\r)0.5( )0.5(\f)]TJ /Span<>> BDC 5.389 0 Td ( )Tj EMC [(\017)0.5(\007)0.5(\017)0.5(\024)0.5(\023)0.5(\026)0.5(\021)0.5(\017\004)0.5(\036)0.5(\f)0.5(\022)0.5(\017)0.5(\n)0.5( \n)0.5(\036)0.5(\020)0.5(\026)0.5(\022)0.5(\024\035)0.5(\024)0.5(\027)0.5(/)0.5(\n)0.5(\036)0.5(\020)0.5(\026\030)0.5(\036)0.5(\022)0.5(\021)0.5(\031)0.5(\n)0.5(.)0.5( )]TJ /T1_0 1 Tf -0.02 Tw [(\222)0.5(\n)0.5(\023)0.5(\n)0.5(\033)0.5(\032\n)0.5(\013)0.5(\024)0.5(\n)0.5(\023)0.5(\n)0.5(\202)0.5(\025)0.5(\002)0.5(.)]TJ /T1_3 1 Tf 0 Tc 0 Tw 25.941 0 Td ( )Tj 0.023 Tc 0.024 Tw -56.693 -1.2 Td (2024; \021.)Tj /Span<>> BDC ( )Tj EMC (23, \225)Tj /Span<>> BDC ( )Tj EMC [(1, )0.5(\f.)]TJ /Span<>> BDC ( )Tj EMC (32\22641. https://doi.org/10.33878/2073-7556-2024-23-1-32-41)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0 Tc 0.023 Tw 18 0 0 18 147.9371 185.3639 Tm [(Risk factor)20.1(s of sigmoid v)10(olv)10(ulus in patients )]TJ 3.06 -1.167 Td (with idiopathic megacolon)Tj 0 0 0 1 k /GS1 gs 0 Tw 14 0 0 14 70.8661 139.86 Tm [(Denis\022)-23.2(V)62(.\022)-23.3(Aleshin)]TJ 8.162 0 0 8.162 160.5842 144.522 Tm (1)Tj 0.023 Tw 14 0 0 14 165.2201 139.86 Tm [(, Ser)31(gey\022)-23.2(I.\022)-23.3(Achkasov)]TJ -0.069 Tc 0.069 Tw 8.162 0 0 8.162 280.9688 144.522 Tm [(1,)-69(2)]TJ 0 Tc 0.023 Tw 14 0 0 14 292.2894 139.86 Tm [(, Dmitriy\022)-23.3(G.\022)-23.3(Shakhmatov)]TJ -0.069 Tc 0.069 Tw 8.162 0 0 8.162 430.1433 144.522 Tm [(1,)-69(2)]TJ 0 Tc 0 Tw 14 0 0 14 441.464 139.86 Tm (, )Tj -26.471 -1.143 Td [(Ok)11(sana\022)-23.2(Y)40(u.\022)-23.3(F)15(omenk)11(o)]TJ 8.162 0 0 8.162 189.4391 128.522 Tm (1)Tj 0.023 Tw 14 0 0 14 194.075 123.86 Tm [(, Alek)11(sey\022)-23.2(A)-31(.\022)-23.3(P)10(onomar)31(enk)11.1(o)]TJ 0 Tw 8.162 0 0 8.162 342.7372 128.522 Tm (1)Tj 0.023 Tw 14 0 0 14 347.3732 123.86 Tm [(, Maria\022)-23.2(A)-31(.\022)-23.3(Ignatenk)11.1(o)]TJ 0 Tw 8.162 0 0 8.162 465.9635 128.522 Tm (1)Tj 14 0 0 14 470.5994 123.86 Tm (, )Tj -28.552 -1.143 Td [(Ev)10(geniy\022)-23.2(S.\022)-23.3(Sur)20(ov)12(egin)]TJ 8.162 0 0 8.162 188.6967 112.522 Tm (1)Tj 0.023 Tw 14 0 0 14 193.3327 107.86 Tm [(, Oleg\022)-23.2(I.\022)-23.3(Sushk)11(ov)]TJ -0.069 Tc 0.069 Tw 8.162 0 0 8.162 289.6776 112.522 Tm [(1,)-69(2)]TJ 0 Tc 0 Tw 5.83 0 0 5.83 70.8661 93.5207 Tm (1)Tj 0.023 Tw 10 0 0 10 74.1775 90.1907 Tm [(R)20(y)21(zhikh National Medical Resear)31(ch Center of Colopr)20.1(octology \(Saly)21(ama Adily)21(a\022)-23.3(st., 2, Moscow)22(, 1)125(23)58(423, Russia\))]TJ 0 Tw ( )Tj ET 1 0.68 0 0.12 k /GS0 gs q 1 0 0 1 70.8661 582.1533 cm 0 0 m 0 0 l 0 -11.339 l 42.52 -11.339 l 42.52 0 l h f Q BT 0 0 0 0 k /T1_2 1 Tf 9 0 0 9 76.0071 573.226 Tm (\021\033\r\035\f\033)Tj 1 0.68 0 0.12 k /T1_1 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\033\030\031\030\213\b)-20.9(\035\231\213\233\t \021\032)50(\b)42(\032\231\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj -51.938 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 23, \023\0221)69(, 202)69(4)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 23, \023\0221)69(, 202)69(4)]TJ /T1_4 1 Tf 25 0 0 25 28.09 56.0378 Tm (32)Tj ET q 0 g 0 G 0 j 0 J /Fm1 Do Q 0 0 0 0 k 396.85 725.67 59.155 11.338 re f /PlacedPDF /MC0 BDC q 397.481 736.808 m 397.242 736.808 397.049 736.616 397.049 736.376 c 397.049 736.376 l 397.049 726.285 l 397.049 726.045 397.242 725.853 397.481 725.853 c 397.481 725.853 l 455.382 725.853 l 455.62 725.853 455.815 726.045 455.815 726.285 c 455.815 726.285 l 455.815 736.376 l 455.815 736.616 455.62 736.808 455.382 736.808 c 455.382 736.808 l h W n q 0 g -0.0000005 -10.9560913 -10.9560913 0.0000005 426.4320445 736.8086309 cm BX /Sh0 sh EX Q Q q 396.85 725.67 59.155 11.337 re W n 0 0 0 0.84 k q 1 0 0 1 413.5634 732.4249 cm 0 0 m -0.025 0.1 -0.063 0.196 -0.112 0.287 c -0.157 0.374 -0.218 0.451 -0.292 0.515 c -0.37 0.582 -0.46 0.632 -0.558 0.664 c -0.669 0.701 -0.786 0.719 -0.903 0.717 c -1.076 0.722 -1.247 0.681 -1.4 0.6 c -1.536 0.526 -1.652 0.42 -1.74 0.292 c -1.83 0.158 -1.895 0.008 -1.934 -0.149 c -2.018 -0.48 -2.018 -0.827 -1.934 -1.158 c -1.896 -1.316 -1.83 -1.466 -1.74 -1.602 c -1.653 -1.731 -1.536 -1.837 -1.4 -1.912 c -1.247 -1.993 -1.076 -2.033 -0.903 -2.029 c -0.774 -2.032 -0.647 -2.006 -0.528 -1.955 c -0.427 -1.906 -0.337 -1.837 -0.263 -1.753 c -0.185 -1.665 -0.124 -1.563 -0.082 -1.453 c -0.034 -1.338 0 -1.218 0.019 -1.094 c 0.635 -1.094 l 0.624 -1.297 0.578 -1.497 0.497 -1.684 c 0.421 -1.857 0.312 -2.015 0.175 -2.146 c 0.039 -2.277 -0.123 -2.379 -0.3 -2.446 c -0.492 -2.519 -0.695 -2.555 -0.9 -2.552 c -1.15 -2.557 -1.397 -2.506 -1.625 -2.404 c -1.829 -2.307 -2.01 -2.169 -2.157 -1.997 c -2.308 -1.821 -2.423 -1.617 -2.497 -1.397 c -2.655 -0.924 -2.655 -0.412 -2.497 0.061 c -2.423 0.281 -2.307 0.485 -2.157 0.661 c -2.01 0.833 -1.829 0.973 -1.625 1.07 c -1.398 1.174 -1.15 1.226 -0.9 1.222 c -0.707 1.223 -0.515 1.196 -0.329 1.14 c -0.159 1.088 0.001 1.006 0.144 0.898 c 0.278 0.793 0.39 0.662 0.473 0.513 c 0.562 0.349 0.615 0.167 0.629 -0.019 c 0 -0.019 l 0 0 l f Q q 1 0 0 1 414.6923 733.5723 cm 0 0 m 0.584 0 l 0.584 -1.328 l 0.662 -1.204 0.771 -1.103 0.9 -1.033 c 1.046 -0.951 1.213 -0.91 1.381 -0.914 c 1.627 -0.9 1.869 -0.979 2.058 -1.137 c 2.234 -1.312 2.325 -1.556 2.305 -1.803 c 2.305 -3.596 l 1.716 -3.596 l 1.716 -1.976 l 1.724 -1.817 1.678 -1.66 1.585 -1.53 c 1.486 -1.43 1.347 -1.379 1.206 -1.392 c 1.114 -1.39 1.024 -1.408 0.94 -1.445 c 0.865 -1.479 0.798 -1.529 0.744 -1.591 c 0.687 -1.656 0.645 -1.73 0.616 -1.812 c 0.586 -1.896 0.571 -1.986 0.571 -2.077 c 0.571 -3.615 l 0 -3.615 l 0 0 l f Q q 1 0 0 1 418.0385 731.1235 cm 0 0 m 0 -0.099 0.014 -0.198 0.043 -0.292 c 0.069 -0.382 0.112 -0.466 0.17 -0.54 c 0.229 -0.611 0.304 -0.669 0.388 -0.709 c 0.486 -0.754 0.594 -0.776 0.702 -0.773 c 0.845 -0.78 0.987 -0.742 1.108 -0.664 c 1.217 -0.582 1.296 -0.468 1.336 -0.337 c 1.881 -0.337 l 1.827 -0.603 1.675 -0.838 1.456 -0.996 c 1.35 -1.073 1.231 -1.131 1.105 -1.169 c 0.971 -1.208 0.831 -1.229 0.691 -1.227 c 0.509 -1.227 0.328 -1.191 0.16 -1.121 c 0.007 -1.063 -0.13 -0.972 -0.244 -0.855 c -0.356 -0.73 -0.44 -0.583 -0.491 -0.422 c -0.548 -0.243 -0.576 -0.056 -0.574 0.133 c -0.575 0.313 -0.545 0.493 -0.486 0.664 c -0.426 0.826 -0.335 0.974 -0.22 1.102 c 0.004 1.375 0.338 1.534 0.691 1.535 c 0.883 1.539 1.072 1.495 1.243 1.408 c 1.402 1.326 1.541 1.209 1.649 1.067 c 1.759 0.922 1.838 0.757 1.883 0.582 c 1.932 0.396 1.945 0.203 1.92 0.013 c 0 0.013 l 0 0 l 1.342 0.377 m 1.335 0.468 1.315 0.557 1.283 0.643 c 1.253 0.724 1.209 0.798 1.153 0.863 c 1.097 0.922 1.03 0.97 0.957 1.004 c 0.874 1.043 0.783 1.063 0.691 1.062 c 0.6 1.062 0.509 1.044 0.425 1.009 c 0.345 0.976 0.273 0.926 0.213 0.863 c 0.153 0.799 0.105 0.724 0.072 0.643 c 0.037 0.559 0.017 0.468 0.014 0.377 c 1.355 0.377 l h f Q q 1 0 0 1 422.1581 731.7051 cm 0 0 m -0.012 0.144 -0.082 0.276 -0.194 0.366 c -0.31 0.452 -0.451 0.495 -0.595 0.489 c -0.675 0.488 -0.755 0.476 -0.831 0.452 c -0.918 0.424 -0.998 0.375 -1.062 0.311 c -1.142 0.229 -1.202 0.131 -1.24 0.024 c -1.29 -0.132 -1.312 -0.296 -1.304 -0.459 c -1.304 -0.569 -1.292 -0.677 -1.267 -0.784 c -1.244 -0.885 -1.202 -0.983 -1.145 -1.07 c -1.09 -1.154 -1.016 -1.224 -0.93 -1.275 c -0.833 -1.33 -0.722 -1.356 -0.611 -1.352 c -0.457 -1.357 -0.307 -1.301 -0.194 -1.195 c -0.078 -1.077 -0.005 -0.922 0.011 -0.757 c 0.587 -0.757 l 0.556 -1.055 0.419 -1.332 0.202 -1.538 c -0.022 -1.721 -0.306 -1.815 -0.595 -1.803 c -0.777 -1.806 -0.958 -1.771 -1.126 -1.7 c -1.293 -1.642 -1.445 -1.547 -1.57 -1.421 c -1.68 -1.297 -1.763 -1.151 -1.814 -0.993 c -1.87 -0.822 -1.898 -0.643 -1.896 -0.462 c -1.898 -0.276 -1.871 -0.091 -1.817 0.087 c -1.766 0.252 -1.682 0.405 -1.57 0.537 c -1.459 0.664 -1.323 0.766 -1.168 0.834 c -0.991 0.914 -0.798 0.955 -0.603 0.954 c -0.457 0.954 -0.311 0.935 -0.17 0.895 c -0.039 0.858 0.084 0.799 0.194 0.72 c 0.302 0.643 0.393 0.543 0.459 0.428 c 0.531 0.298 0.572 0.155 0.582 0.008 c 0 0.008 l 0 0 l f Q q 1 0 0 1 423.2177 733.5723 cm 0 0 m 0.577 0 l 0.577 -2.048 l 1.615 -0.985 l 2.322 -0.985 l 1.323 -1.944 l 2.417 -3.604 l 1.716 -3.604 l 0.919 -2.337 l 0.577 -2.669 l 0.577 -3.604 l 0 -3.604 l h f Q q 1 0 0 1 427.0585 732.5762 cm 0 0 m 0.436 0 l 0.436 0.218 l 0.429 0.352 0.448 0.486 0.488 0.614 c 0.521 0.705 0.577 0.786 0.651 0.85 c 0.717 0.905 0.795 0.943 0.879 0.961 c 0.966 0.979 1.056 0.988 1.145 0.988 c 1.28 0.993 1.416 0.981 1.548 0.954 c 1.548 0.505 l 1.509 0.516 1.469 0.523 1.429 0.528 c 1.379 0.532 1.33 0.532 1.28 0.528 c 1.209 0.53 1.14 0.511 1.081 0.473 c 1.019 0.419 0.987 0.337 0.999 0.255 c 0.999 -0.011 l 1.498 -0.011 l 1.498 -0.441 l 1.009 -0.441 l 1.009 -2.622 l 0.436 -2.622 l 0.436 -0.428 l 0.005 -0.428 l 0.005 0 l 0 0 l f Q q 1 0 0 1 430.1 729.8965 cm 0 0 m -0.191 -0.003 -0.381 0.032 -0.559 0.104 c -0.715 0.167 -0.856 0.264 -0.972 0.388 c -1.091 0.512 -1.181 0.659 -1.238 0.82 c -1.356 1.18 -1.356 1.567 -1.238 1.925 c -1.181 2.087 -1.091 2.234 -0.972 2.358 c -0.856 2.481 -0.715 2.578 -0.559 2.643 c -0.199 2.78 0.198 2.78 0.558 2.643 c 0.714 2.578 0.855 2.481 0.972 2.358 c 1.09 2.234 1.181 2.087 1.237 1.925 c 1.355 1.567 1.355 1.18 1.237 0.82 c 1.181 0.659 1.09 0.512 0.972 0.388 c 0.855 0.266 0.713 0.169 0.558 0.106 c 0.38 0.034 0.191 -0.002 0 0 c 0 0.454 m 0.115 0.451 0.23 0.479 0.332 0.534 c 0.424 0.586 0.502 0.659 0.562 0.746 c 0.624 0.836 0.669 0.936 0.695 1.041 c 0.752 1.26 0.752 1.491 0.695 1.71 c 0.669 1.816 0.625 1.916 0.562 2.005 c 0.502 2.091 0.423 2.163 0.332 2.215 c 0.123 2.323 -0.126 2.323 -0.335 2.215 c -0.427 2.163 -0.505 2.091 -0.566 2.005 c -0.628 1.916 -0.673 1.816 -0.699 1.71 c -0.756 1.491 -0.756 1.26 -0.699 1.041 c -0.672 0.936 -0.627 0.836 -0.566 0.746 c -0.506 0.659 -0.427 0.586 -0.335 0.534 c -0.232 0.478 -0.117 0.451 0 0.454 c f Q q 1 0 0 1 431.8979 732.5762 cm 0 0 m 0.531 0 l 0.531 -0.505 l 0.55 -0.43 0.583 -0.359 0.629 -0.297 c 0.681 -0.229 0.74 -0.167 0.807 -0.114 c 0.877 -0.059 0.956 -0.014 1.039 0.019 c 1.123 0.053 1.213 0.07 1.304 0.069 c 1.52 0.069 l 1.52 -0.486 l 1.395 -0.467 l 1.269 -0.467 l 1.178 -0.468 1.087 -0.488 1.004 -0.526 c 0.917 -0.565 0.839 -0.625 0.778 -0.699 c 0.716 -0.783 0.669 -0.878 0.643 -0.98 c 0.604 -1.104 0.584 -1.233 0.586 -1.362 c 0.586 -2.603 l 0.01 -2.603 l 0.01 0 l 0 0 l f Q q 1 0 0 1 437.3666 729.9683 cm 0 0 m -0.577 0 l -0.577 0.364 l -0.649 0.23 -0.759 0.121 -0.893 0.047 c -1.022 -0.029 -1.169 -0.07 -1.32 -0.072 c -1.595 -0.095 -1.866 0.002 -2.064 0.194 c -2.234 0.413 -2.316 0.687 -2.295 0.964 c -2.295 2.608 l -1.719 2.608 l -1.719 1.014 l -1.735 0.843 -1.689 0.67 -1.588 0.531 c -1.492 0.433 -1.357 0.382 -1.219 0.39 c -1.116 0.387 -1.012 0.406 -0.917 0.446 c -0.84 0.479 -0.772 0.531 -0.72 0.595 c -0.667 0.661 -0.63 0.738 -0.611 0.82 c -0.588 0.911 -0.577 1.003 -0.577 1.097 c -0.577 2.611 l 0 2.611 l 0 0 l f Q q 1 0 0 1 437.9877 732.5762 cm 0 0 m 0.545 0 l 0.545 -0.353 l 0.617 -0.209 0.736 -0.094 0.882 -0.026 c 1.03 0.04 1.19 0.073 1.352 0.072 c 1.535 0.075 1.717 0.038 1.883 -0.037 c 2.031 -0.106 2.161 -0.208 2.263 -0.334 c 2.366 -0.465 2.442 -0.615 2.489 -0.775 c 2.54 -0.948 2.566 -1.127 2.566 -1.307 c 2.566 -1.479 2.542 -1.651 2.497 -1.817 c 2.455 -1.973 2.385 -2.121 2.29 -2.252 c 2.099 -2.522 1.789 -2.682 1.458 -2.68 c 1.369 -2.681 1.28 -2.674 1.193 -2.659 c 1.11 -2.644 1.028 -2.618 0.951 -2.584 c 0.875 -2.552 0.802 -2.509 0.736 -2.457 c 0.671 -2.406 0.615 -2.343 0.571 -2.273 c 0.571 -3.575 l -0.005 -3.575 l -0.005 0 l 0 0 l 2.008 -1.307 m 2.008 -1.191 1.993 -1.076 1.963 -0.964 c 1.936 -0.859 1.89 -0.759 1.828 -0.669 c 1.768 -0.584 1.69 -0.514 1.599 -0.462 c 1.503 -0.409 1.395 -0.382 1.286 -0.385 c 1.072 -0.372 0.867 -0.467 0.738 -0.638 c 0.607 -0.836 0.543 -1.072 0.555 -1.31 c 0.554 -1.433 0.57 -1.557 0.603 -1.676 c 0.631 -1.781 0.68 -1.879 0.747 -1.965 c 0.809 -2.044 0.886 -2.109 0.975 -2.157 c 1.071 -2.206 1.178 -2.23 1.286 -2.229 c 1.401 -2.232 1.517 -2.205 1.618 -2.148 c 1.708 -2.096 1.785 -2.025 1.843 -1.939 c 1.903 -1.85 1.945 -1.751 1.968 -1.646 c 1.995 -1.535 2.008 -1.421 2.008 -1.307 c f Q q 1 0 0 1 443.5127 729.9683 cm 0 0 m -0.545 0 l -0.545 0.353 l -0.616 0.211 -0.734 0.099 -0.879 0.034 c -1.027 -0.031 -1.187 -0.065 -1.349 -0.064 c -1.532 -0.067 -1.714 -0.03 -1.88 0.045 c -2.028 0.113 -2.158 0.214 -2.26 0.34 c -2.364 0.47 -2.441 0.62 -2.486 0.781 c -2.538 0.958 -2.564 1.143 -2.563 1.328 c -2.568 1.536 -2.536 1.742 -2.468 1.938 c -2.41 2.097 -2.319 2.242 -2.202 2.364 c -2.101 2.471 -1.977 2.555 -1.838 2.608 c -1.705 2.659 -1.563 2.685 -1.421 2.685 c -1.338 2.685 -1.256 2.678 -1.174 2.664 c -1.091 2.648 -1.01 2.624 -0.932 2.589 c -0.855 2.556 -0.783 2.514 -0.717 2.462 c -0.652 2.411 -0.597 2.349 -0.553 2.279 c -0.553 3.606 l 0.024 3.606 l 0.024 0 l 0 0 l -2.008 1.277 m -2.009 1.166 -1.994 1.056 -1.965 0.948 c -1.939 0.845 -1.896 0.748 -1.835 0.661 c -1.777 0.578 -1.699 0.508 -1.61 0.459 c -1.404 0.355 -1.162 0.355 -0.956 0.459 c -0.866 0.512 -0.789 0.585 -0.73 0.671 c -0.671 0.762 -0.626 0.862 -0.6 0.966 c -0.572 1.076 -0.558 1.188 -0.558 1.301 c -0.543 1.542 -0.612 1.781 -0.751 1.979 c -0.88 2.14 -1.078 2.229 -1.283 2.22 c -1.402 2.224 -1.52 2.196 -1.623 2.138 c -1.714 2.083 -1.793 2.009 -1.852 1.92 c -1.911 1.828 -1.954 1.725 -1.977 1.617 c -1.999 1.505 -2.01 1.392 -2.008 1.277 c f Q q 1 0 0 1 446.3252 730.5499 cm 0 0 m -0.004 -0.052 0.005 -0.104 0.026 -0.151 c 0.052 -0.185 0.094 -0.202 0.136 -0.197 c 0.197 -0.197 l 0.223 -0.2 0.25 -0.2 0.276 -0.197 c 0.276 -0.595 l 0.199 -0.619 l 0.101 -0.64 l 0 -0.656 l -0.085 -0.656 l -0.187 -0.66 -0.288 -0.635 -0.377 -0.584 c -0.461 -0.528 -0.516 -0.437 -0.528 -0.337 c -0.648 -0.451 -0.792 -0.534 -0.951 -0.579 c -1.106 -0.628 -1.269 -0.654 -1.432 -0.656 c -1.546 -0.657 -1.659 -0.641 -1.769 -0.608 c -1.872 -0.579 -1.967 -0.531 -2.053 -0.468 c -2.136 -0.405 -2.203 -0.324 -2.25 -0.231 c -2.3 -0.127 -2.326 -0.012 -2.324 0.104 c -2.33 0.24 -2.299 0.375 -2.236 0.497 c -2.181 0.594 -2.101 0.675 -2.005 0.733 c -1.905 0.791 -1.795 0.833 -1.681 0.855 c -1.562 0.88 -1.442 0.899 -1.32 0.914 c -1.222 0.933 -1.123 0.947 -1.022 0.956 c -0.938 0.963 -0.855 0.977 -0.773 0.999 c -0.708 1.014 -0.649 1.046 -0.6 1.092 c -0.556 1.144 -0.533 1.211 -0.536 1.28 c -0.534 1.344 -0.553 1.408 -0.59 1.46 c -0.624 1.507 -0.668 1.544 -0.72 1.569 c -0.775 1.596 -0.834 1.613 -0.895 1.62 c -0.955 1.624 -1.016 1.624 -1.076 1.62 c -1.215 1.625 -1.354 1.591 -1.474 1.519 c -1.581 1.45 -1.647 1.333 -1.652 1.206 c -2.231 1.206 l -2.227 1.354 -2.185 1.498 -2.108 1.625 c -2.041 1.733 -1.951 1.824 -1.843 1.891 c -1.729 1.96 -1.603 2.007 -1.472 2.032 c -1.329 2.072 -1.183 2.098 -1.036 2.109 c -0.908 2.109 -0.781 2.096 -0.656 2.069 c -0.538 2.044 -0.425 2 -0.321 1.939 c -0.225 1.88 -0.143 1.8 -0.083 1.705 c -0.02 1.599 0.012 1.478 0.008 1.354 c 0.008 0.013 l 0 0 l -0.576 0.728 m -0.674 0.667 -0.785 0.631 -0.9 0.624 c -1.028 0.612 -1.155 0.594 -1.283 0.571 c -1.343 0.561 -1.402 0.547 -1.46 0.528 c -1.515 0.511 -1.566 0.485 -1.612 0.451 c -1.657 0.419 -1.692 0.376 -1.716 0.327 c -1.742 0.267 -1.755 0.203 -1.753 0.138 c -1.755 0.079 -1.735 0.021 -1.697 -0.024 c -1.661 -0.067 -1.615 -0.103 -1.564 -0.127 c -1.509 -0.154 -1.451 -0.171 -1.392 -0.181 c -1.335 -0.19 -1.278 -0.196 -1.222 -0.197 c -1.152 -0.196 -1.083 -0.188 -1.015 -0.173 c -0.94 -0.156 -0.87 -0.127 -0.805 -0.088 c -0.74 -0.048 -0.684 0.004 -0.64 0.066 c -0.594 0.134 -0.571 0.215 -0.574 0.297 c -0.574 0.725 l h f Q q 1 0 0 1 446.6836 732.5762 cm 0 0 m 0.434 0 l 0.434 0.784 l 0.996 0.784 l 0.996 0 l 1.527 0 l 1.527 -0.43 l 0.996 -0.43 l 0.996 -1.822 l 0.993 -1.874 0.993 -1.927 0.996 -1.979 c 1 -2.018 1.011 -2.056 1.031 -2.09 c 1.05 -2.122 1.079 -2.146 1.113 -2.159 c 1.162 -2.177 1.213 -2.185 1.265 -2.183 c 1.387 -2.183 l 1.428 -2.181 1.469 -2.175 1.509 -2.165 c 1.509 -2.608 l 1.323 -2.629 l 1.261 -2.633 1.199 -2.633 1.137 -2.629 c 1.013 -2.633 0.89 -2.619 0.771 -2.587 c 0.688 -2.564 0.613 -2.52 0.553 -2.459 c 0.499 -2.4 0.462 -2.328 0.446 -2.25 c 0.427 -2.155 0.416 -2.059 0.415 -1.963 c 0.415 -0.428 l -0.019 -0.428 l -0.019 0 l 0 0 l f Q q 1 0 0 1 449.0742 731.1235 cm 0 0 m 0 -0.099 0.014 -0.198 0.042 -0.292 c 0.068 -0.382 0.112 -0.466 0.17 -0.54 c 0.229 -0.611 0.303 -0.669 0.388 -0.709 c 0.486 -0.754 0.593 -0.776 0.701 -0.773 c 0.845 -0.78 0.987 -0.742 1.107 -0.664 c 1.216 -0.582 1.296 -0.468 1.336 -0.337 c 1.88 -0.337 l 1.827 -0.603 1.674 -0.838 1.456 -0.996 c 1.349 -1.073 1.231 -1.131 1.105 -1.169 c 0.973 -1.208 0.836 -1.228 0.699 -1.227 c 0.512 -1.23 0.327 -1.196 0.154 -1.126 c 0.003 -1.066 -0.133 -0.973 -0.244 -0.855 c -0.356 -0.73 -0.44 -0.583 -0.491 -0.422 c -0.548 -0.243 -0.576 -0.056 -0.574 0.133 c -0.575 0.313 -0.546 0.493 -0.486 0.664 c -0.426 0.826 -0.336 0.974 -0.221 1.102 c 0.002 1.374 0.334 1.532 0.685 1.535 c 0.877 1.539 1.067 1.495 1.238 1.408 c 1.396 1.326 1.535 1.209 1.644 1.067 c 1.753 0.922 1.833 0.757 1.878 0.582 c 1.927 0.396 1.939 0.203 1.915 0.013 c -0.002 0.013 l 0 0 l 1.341 0.377 m 1.335 0.468 1.315 0.557 1.283 0.643 c 1.253 0.724 1.209 0.798 1.153 0.863 c 1.096 0.926 1.027 0.978 0.951 1.014 c 0.868 1.054 0.777 1.074 0.685 1.073 c 0.594 1.073 0.504 1.055 0.419 1.02 c 0.339 0.986 0.267 0.937 0.207 0.874 c 0.147 0.81 0.099 0.735 0.066 0.653 c 0.031 0.569 0.011 0.479 0.008 0.388 c 1.349 0.388 l h f Q q 1 0 0 1 451.8657 730.7994 cm 0 0 m 0.002 -0.142 0.073 -0.274 0.191 -0.353 c 0.312 -0.423 0.45 -0.458 0.59 -0.454 c 0.651 -0.458 0.711 -0.458 0.773 -0.454 c 0.839 -0.447 0.904 -0.43 0.967 -0.406 c 1.024 -0.385 1.075 -0.349 1.116 -0.303 c 1.155 -0.252 1.174 -0.189 1.168 -0.125 c 1.166 -0.057 1.138 0.008 1.089 0.056 c 1.033 0.107 0.967 0.146 0.895 0.17 c 0.809 0.201 0.72 0.226 0.629 0.245 c 0.329 0.33 l 0.224 0.352 0.121 0.38 0.019 0.415 c -0.076 0.446 -0.166 0.491 -0.247 0.55 c -0.327 0.608 -0.391 0.683 -0.436 0.771 c -0.486 0.873 -0.511 0.986 -0.507 1.1 c -0.512 1.226 -0.475 1.351 -0.404 1.456 c -0.333 1.551 -0.243 1.63 -0.138 1.687 c -0.028 1.747 0.092 1.788 0.215 1.809 c 0.337 1.832 0.462 1.843 0.587 1.843 c 0.716 1.844 0.845 1.83 0.972 1.801 c 1.09 1.774 1.202 1.727 1.304 1.663 c 1.404 1.598 1.488 1.513 1.551 1.413 c 1.621 1.3 1.663 1.173 1.676 1.041 c 1.076 1.041 l 1.059 1.155 0.989 1.253 0.887 1.307 c 0.78 1.355 0.665 1.38 0.547 1.378 c 0.5 1.381 0.452 1.381 0.403 1.378 c 0.35 1.373 0.298 1.36 0.247 1.341 c 0.2 1.325 0.157 1.297 0.122 1.262 c 0.087 1.224 0.069 1.174 0.071 1.124 c 0.069 1.058 0.096 0.995 0.146 0.951 c 0.202 0.903 0.267 0.866 0.337 0.842 c 0.424 0.811 0.512 0.786 0.603 0.768 c 0.917 0.701 l 1.021 0.678 1.124 0.65 1.224 0.616 c 1.319 0.584 1.409 0.539 1.49 0.481 c 1.662 0.359 1.762 0.16 1.755 -0.05 c 1.76 -0.189 1.723 -0.326 1.649 -0.443 c 1.582 -0.551 1.491 -0.642 1.384 -0.709 c 1.267 -0.778 1.14 -0.827 1.007 -0.855 c 0.873 -0.885 0.735 -0.9 0.598 -0.9 c 0.443 -0.902 0.29 -0.883 0.141 -0.845 c 0.01 -0.812 -0.114 -0.753 -0.223 -0.674 c -0.324 -0.601 -0.407 -0.504 -0.465 -0.393 c -0.527 -0.269 -0.559 -0.131 -0.558 0.008 c 0.019 0.008 l 0 0 l f Q 0.146 0.941 0.992 0.044 k q 1 0 0 1 401.2527 729.3892 cm 0 0 m 3.612 2.406 l 3.612 5.296 l 0 5.296 l h f Q 0 0.889 0.676 0 k q 1 0 0 1 404.865 729.3892 cm 0 0 m -3.612 2.406 l -3.612 5.296 l 0 5.296 l h f Q 0.694 0.076 0.209 0 k q 1 0 0 1 403.0589 735.3145 cm 0 0 m -2.2 0 -3.984 -1.784 -3.984 -3.984 c -3.984 -6.184 -2.2 -7.968 0 -7.968 c 2.2 -7.968 3.984 -6.184 3.984 -3.984 c 3.984 -1.784 2.2 0 0 0 c 0 -6.993 m -1.662 -6.993 -3.009 -5.646 -3.009 -3.984 c -3.009 -2.322 -1.662 -0.975 0 -0.975 c 1.662 -0.975 3.009 -2.322 3.009 -3.984 c 3.009 -5.646 1.662 -6.993 0 -6.993 c f Q 0 0.235 0.86 0 k q 1 0 0 1 405.2601 729.2803 cm 0 0 m -1.118 -1.208 -3.015 -1.281 -4.237 -0.159 c -5.159 0.688 -5.459 2.005 -4.999 3.156 c -5.833 3.687 l -6.736 1.681 -5.843 -0.679 -3.836 -1.582 c -2.218 -2.311 -0.312 -1.881 0.836 -0.528 c 0 0 l f Q 0 0 0 0.6 k q 1 0 0 1 397.4813 736.8087 cm 0 0 m -0.238 0 -0.432 -0.193 -0.432 -0.432 c -0.432 -10.524 l -0.432 -10.763 -0.238 -10.956 0 -10.956 c 57.901 -10.956 l 58.139 -10.956 58.333 -10.763 58.333 -10.524 c 58.333 -0.432 l 58.333 -0.193 58.139 0 57.901 0 c h 57.901 -11.155 m 0 -11.155 l -0.348 -11.155 -0.631 -10.872 -0.631 -10.524 c -0.631 -0.432 l -0.631 -0.084 -0.348 0.199 0 0.199 c 57.901 0.199 l 58.249 0.199 58.532 -0.084 58.532 -0.432 c 58.532 -10.524 l 58.532 -10.872 58.249 -11.155 57.901 -11.155 c f Q EMC Q endstream endobj 2294 0 obj <> endobj 2299 0 obj <>stream Adobe Illustrator CS6 (Windows) 2021-04-12T11:45:36+05:00 2021-06-02T10:28:09+05:00 2021-06-02T10:28:09+05:00 1 False False 20.868494 3.999928 Millimeters Cyan Magenta Yellow Black Default Swatch Group 0 C=0 M=24 Y=86 K=0 PROCESS 100.000000 CMYK 0.000000 23.504999 86.022697 0.000000 C=69 M=8 Y=21 K=0 PROCESS 100.000000 CMYK 69.369003 7.635600 20.892700 0.000000 C=0 M=89 Y=68 K=0 PROCESS 100.000000 CMYK 0.000000 88.946404 67.623398 0.000000 C=15 M=94 Y=99 K=4 PROCESS 100.000000 CMYK 14.578501 94.070297 99.160698 4.416000 C=0 M=0 Y=0 K=84 PROCESS 100.000000 CMYK 0.000000 0.000000 0.000000 84.000000 C=0 M=0 Y=0 K=35 PROCESS 100.000000 CMYK 0.000000 0.000000 0.000000 35.000000 C=0 M=0 Y=0 K=60 PROCESS 100.000000 CMYK 0.000000 0.000000 0.000000 60.000004 Document application/pdf proof:pdf xmp.did:804244B35A9BEB118A6FC3C256996E2F uuid:08e30110-bdb7-4606-97ca-63fb62cbcecc uuid:21079f76-f6d7-4329-b725-f2fb35af5114 uuid:722f8893-0b3c-4402-87fb-c713f1fa0e26 uuid:21079f76-f6d7-4329-b725-f2fb35af5114 uuid:21079f76-f6d7-4329-b725-f2fb35af5114 proof:pdf saved xmp.iid:804244B35A9BEB118A6FC3C256996E2F 2021-04-12T11:45:42+05:00 Adobe Illustrator CS6 (Windows) / endstream endobj 2298 0 obj <>/Border[0 0 0]/H/N/Rect[394.85 739.008 458.005 723.67]/Subtype/Link/Type/Annot>> endobj 2300 0 obj <> endobj 2290 0 obj [2301 0 R 2302 0 R 2303 0 R 2304 0 R 2305 0 R 2306 0 R 2307 0 R 2308 0 R 2309 0 R 2310 0 R 2311 0 R 2312 0 R 2313 0 R 2314 0 R 2315 0 R 2316 0 R 2317 0 R 2318 0 R 2319 0 R 2320 0 R 2321 0 R 2322 0 R 2323 0 R 2324 0 R 2325 0 R 2326 0 R 2327 0 R 2328 0 R] endobj 2291 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\235\001\201\025\006\n)10(\025\221\220\017\016\006\n\013\205 \024\215\n)10(\025)21(\222)21(\232\n)-9.9(\026)11(\025\024\220\205 \006\022\227\220\002\n\215\007\205\002\001\020\024 \002\ \013\222\002\016\222\025\024 )]TJ 0 -1 TD [(\006)-10(\007\220\222\220\006)-9.9(\026)11(\025\203 \025\f\025\007\025\017\n\220 \r\022\007\016\017\016\001\220\220\ \025\221\215)21.1(\207\025\007\016\203 \025\f\025\201\025\017\001\025\203 \n\220\n\220. )]TJ T* [(\033\016\222)21(\215\007\216)21(\026)11(\013\026\020 \002\013\001\201\025\024\220\222\220\002\025\r\013\001\001\025\ \202)10(\025 \220\006\006)-10(\007\016\201\025\r\013\001\220\205.)]TJ 34.507 2 Td [(Endoscopic mucosal r)31(esection with a cir)31(cumfer)31.1(ential incision in th)11(e )]TJ 2.851 -1 Td [(r)31(emov)10(al of colon neoplasms. Results of a r)21(andomiz)10.1(ed trial.)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 8 0 0 8 42.5197 731.2159 Tm [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.33878/2073-7556-2022-21-4-21-29)Tj 0 0 0 1 k /GS1 gs 0.154 Tw -1.847 -1.25 Td (6.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(T)40(akuji Go)17(t)17(od)42(a, Hir)-32(onor)-37(i Y)50(amamo)17(t)17.1(o, R)11(oy)]TJ /Span<>> BDC ( )Tj EMC [(M. S)-16(oe)-12(t)-32(ikno End)-16(oscopic )]TJ 0.019 Tw -1.296 -1.25 Td [(submucosal dissec)-16(t)-32(ion of ear)-30(l)35(y gastr)-37(ic cancer. )]TJ /T1_2 1 Tf (J Gastroenterol.)Tj /T1_1 1 Tf ( 2006; )Tj 0.023 Tw 0 -1.25 TD [(41\(10\), 929\226942. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1007/s00535-006-1954-3)Tj 0 0 0 1 k /GS1 gs 0.039 Tw T* (7.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(W)-16(inter)]TJ /Span<>> BDC ( )Tj EMC [(K, W\242od)42(ar)-32(czyk)]TJ /Span<>> BDC ( )Tj EMC [(M, W\242od)42.1(ar)-32(czyk)]TJ /Span<>> BDC ( )Tj EMC [(J, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. R)-24(isk S)15(tr)-33(a)15(t)-32(if)-27.9(ica)15(t)-32(ion of )]TJ 0.008 Tw -1.296 -1.25 Td [(End)-16(oscopic Submucosal Dissec)-15.9(t)-32(ion in Col)30(on T)60(umor)-10(s. )]TJ /T1_2 1 Tf (J Clin Med.)Tj /T1_1 1 Tf ( 2022 )Tj 0.281 Tw T* [(Mar 12;11\(6\):1560. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.3390/jcm11061560)Tj 0 0 0 1 k /GS1 gs 0.281 Tw ( PMID: 35329886; )Tj 0.023 Tw T* (PMCID: PMC8949025.)Tj 0.022 Tw T* (8.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Y)35(un Jung Kim, Eun S)-16(o)-15.9(o Kim, K)20(w)-12(ang Bum Cho, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Com)10(p)32(ar)-37(ison of )]TJ 0.149 Tw -1.296 -1.25 Td [(Cl)-31(inical Outcomes Among Dif)-56(fer)-24(ent End)-16(oscopic R)13(esec)-16(t)-32(ion Me)-12(t)-13(hods )]TJ 0.063 Tw T* [(for T)50(r)-24(ea)15(t)-32(ing Col)30(or)-24(ec)-16(t)15(al Neopl)-16(asia. )]TJ /T1_2 1 Tf (Clin Endosc)Tj /T1_1 1 Tf (. 2018;51\(3\):266\226273. )Tj 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1007/s10620-013-2560-x)Tj 0 0 0 1 k /GS1 gs 0.153 Tw -1.847 -1.25 Td (9.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Y)40(oshid)42(a)]TJ /Span<>> BDC ( )Tj EMC (N, Inoue)Tj /Span<>> BDC ( )Tj EMC (K, Dohi)Tj /Span<>> BDC ( )Tj EMC [(O, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Ef)-56(f)-28(ica)-17(cy of p)25(r)-24(ecut)-30(t)-32(ing end)-16(o)]TJ 0 Tw (-)Tj 0.004 Tw -1.296 -1.25 Td [(scopic )0.5(mucosal )0.5(r)-24(esec)-16(t)-31.9(ion wi)-24(t)-12.9(h full )0.5(or )0.5(p)32(ar)-22(t)-31.9(ial c)-24(ir)-31.9(cumfer)-24(ent)-31.9(ial inc)-23.9(ision )]TJ 0.185 Tw T* [(using )0.5(a snar)-24(e t)-32(ip )0.5(for dif)-56(f)-27.9(icul)56(t col)30(or)-23.9(ec)-16(t)15(al lesions. )]TJ /T1_2 1 Tf 0 Tw 20.844 0 Td [(Endoscop)12.1(y)]TJ /T1_1 1 Tf 0.185 Tw (. 2019 )Tj 0.181 Tw -20.844 -1.25 Td [(Sep;51\(9\):871\226876. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1055/a-0956-6879)Tj 0 0 0 1 k /GS1 gs 0.181 Tw ( Epub 2019 Jul 15. )Tj 0.023 Tw T* (PMID: 31307100.)Tj 0.317 Tw T* (10.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Dong-Ho)-16(on Y)50(ang, Min-Seob K)20(w)-12(ak, Sang Hyoung P)40(ar)-24(k, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC (al. )Tj 0.014 Tc 0.52 Tw -1.796 -1.25 Td [(End)-16.1(oscopic Mucosal R)12.8(esec)-16.2(t)-32.1(ion wi)-24.2(t)-13.1(h Cir)-32.1(cumfer)-24.2(ent)-32.2(ial Mucosal)14.1( )]TJ 0.001 Tc 0.35 Tw T* [(Inc)-24.4(ision for Col)29.6(or)-24.4(ec)-16.4(t)14.6(al Neopl)-16.5(as)25.6(ms: Com)9.6(p)31.6(ar)-37.3(ison wi)-24.4(t)-13.3(h End)-16.4(oscopic)1( )]TJ 0 Tc -0.026 Tw T* [(Submucosal )0.6(Dissec)-16(t)-32(ion )0.6(and )0.5(be)-11.9(t)-32(ween )0.5(T)60(w)-13.9(o )0.5(End)-16(oscopists )0.6(wi)-24(t)-12.9(h )0.5(Dif)-56(fer)-23.9(ent )]TJ 0 Tw T* [(E)35(xper)-37(iences. )]TJ /T1_2 1 Tf 0.244 Tw 5.544 0 Td (Clin Endosc.)Tj /T1_1 1 Tf [( 2017 Jul;50\(4\):379\226387. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.5946/)Tj -5.544 -1.25 Td (ce.2016.058)Tj 0 0 0 1 k /GS1 gs 0.071 Tw T* (11.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(S)-16(hahini)]TJ /Span<>> BDC ( )Tj EMC [(E, P)40(asser)-32.9(a)]TJ /Span<>> BDC ( )Tj EMC [(R, L)35(o Secco)]TJ /Span<>> BDC ( )Tj EMC [(G, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. A)1( )0.8(s)0.9(y)-11.9(s)1(t)1(e)1(m)1(a)16(t)-31(i)1(c)1( )0.8(r)-23(e)1(v)-15(i)1(e)1(w)1( )0.8(a)1(n)1(d )]TJ -0.001 Tc 0.136 Tw -1.796 -1.25 Td [(me)-12(t)15(a-anal)35(y)-13(sis of end)-16(oscopic mucosal r)-24(esec)-16(t)-32(ion vs end)-16(oscopic sub)]TJ 0 Tc 0 Tw (-)Tj -0.001 Tc -0.028 Tw T* [(mucosal dissec)-16(t)-32(ion for col)30(or)-24(ec)-16(t)15(al sessile/non-pol)34.9(ypoid lesions. )]TJ /T1_2 1 Tf 0 Tc 0 Tw 25.25 0 Td (Minim )Tj 0.013 Tw -25.25 -1.25 Td [(In)11(v)16(asiv)13(e Ther Allied T)54(echnol.)]TJ /T1_1 1 Tf [( 2022 A)10(ug;31\(6\):835\226847. d)-15.9(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1080/)Tj T* (13645706.2022.2032759)Tj 0 0 0 1 k /GS1 gs 0.023 Tw [( Epub 2022 F)10(eb 3. PMID: 35112654.)]TJ -0.002 Tw T* (12.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(L)35(ee Eun-Jung, L)35(ee Jae Bum, L)35(ee Suk Hee, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. End)-15.9(oscopic tr)-23.9(ea)15(t)]TJ 0 Tw (-)Tj 0.062 Tw -1.796 -1.25 Td [(ment of l)-16(ar)-31.9(ge col)30(or)-24(ec)-16(t)15.1(al tumor)-10(s: com)10(p)32(ar)-36.9(ison of end)-16(oscopic mucosal )]TJ -0.042 Tw T* [(r)-24(esec)-15.9(t)-32(ion, end)-16(oscopic mucosal r)-23.9(esec)-16(t)-32(ion\226p)25(r)-24(ecut)-29.9(t)-32(ing, and end)-16(oscopic )]TJ 0.086 Tw T* [(submucosal dissec)-16(t)-32(ion. )]TJ /T1_2 1 Tf [(Surgical Endoscop)12(y. )]TJ /T1_1 1 Tf 0 Tw (2012;26\(8\):2220\2262230. )Tj T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1007/s00464-012-2164-0)Tj 0 0 0 1 k /GS1 gs 0.002 Tw -1.847 -1.25 Td (13.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(R)13(en\351 L)-32(amber)-22(t, S)-16(hin ei K)25(ud)-16(o, Michael V)-14.9(ie)-12(t)-13(h, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. P)35(r)-33(a)-17(gma)15(t)-32(ic cl)-15.9(as)]TJ 0 Tw (-)Tj 0.208 Tw -1.796 -1.25 Td [(sif)-28(ica)15(t)-31.9(ion of )0.5(super)-24(f)-28(ic)-23.9(ial neopl)-16(ast)-31.9(ic col)30(or)-23.9(ec)-16(t)15(al )0.5(lesions. )]TJ /T1_2 1 Tf 0 Tw 22.911 0 Td (Gastrointest )Tj -22.911 -1.25 Td (Endosc.)Tj /T1_1 1 Tf 0.023 Tw [( 2009 Dec;70\(6\):1182\22699. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1016/j.gie.2009.09.015)Tj 0 0 0 1 k /GS1 gs 0.011 Tc 0.424 Tw T* (14.)Tj /Span<>> BDC ( )Tj EMC 1.842 0 Td [(L)-32.4(amber)-22.3(t)]TJ /Span<>> BDC ( )Tj EMC 4.063 0 Td [(R, )0.5(e)-12.4(t)]TJ /Span<>> BDC ( )Tj EMC 2.924 0 Td [(al. )0.5(U)12.5(pd)41.6(a)14.6(te on )0.5(t)-13.4(he )0.5(P)39.6(ar)-37.3(is )0.5(Cl)-16.4(assif)-28.4(ica)14.6(t)-32.4(ion )0.5(of)11( )]TJ 0 Tc 0.25 Tw -8.829 -1.25 Td [(Super)-24(f)-27.9(ic)-24(ial Neopl)-15.9(ast)-32(ic L)35(esions in t)-13(he Digest)-32(i)-16(ve T)49.9(r)-32.9(a)-17(c)-16(t. )]TJ /T1_2 1 Tf 0 Tw [(Endoscop)12.1(y)]TJ /T1_1 1 Tf (. )Tj 0.023 Tw T* [(2005;37\(6\):570\226578. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1055/s-2005-861352)Tj 0 0 0 1 k /GS1 gs -0.008 Tw T* (15.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(K)25(ud)-16(o)]TJ /Span<>> BDC ( )Tj EMC (S, Rubio)Tj /Span<>> BDC ( )Tj EMC 5.673 0 Td [(C)20(A, T)40(eix)12(eir)-32.9(a)]TJ /Span<>> BDC ( )Tj EMC [(CR, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. )0.5(P)-24(i)-24(t p)32(a)15(t)-30(ter)-14.9(n in col)30(or)-24(ec)-16(t)15(al )0.5(neo)]TJ 0 Tw (-)Tj 0.252 Tw -7.469 -1.25 Td [(pl)-16(asia: end)-16(oscopic )0.5(ma)-17(gnif)-34(ying v)-16(iew. )]TJ /T1_2 1 Tf 0 Tw [(Endoscop)12.1(y)]TJ /T1_1 1 Tf 0.252 Tw (. 2001;33\(4\):367\226 )Tj 0.023 Tw T* [(373. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1055/s-2004-826104)Tj 0 0 0 1 k /GS1 gs 0.041 Tw T* (16.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Sano)Tj /Span<>> BDC ( )Tj EMC [(Y, Ik)10(ema)15(tsu)]TJ /Span<>> BDC ( )Tj EMC [(H, F)10(u)]TJ /Span<>> BDC ( )Tj EMC [(KI, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Meshed capill)-15.9(ar)-24(y vessels b)12(y use )]TJ 0.008 Tw 27.259 52.5 Td [(of nar)-24(r)-32(o)-14(w-band ima)-16.9(ging for dif)-55.9(fer)-24(ent)-32(ial dia)-17(gnosis of s)26(mall col)30(or)-24(ec)-16(t)15(al )]TJ 0 Tw T* [(pol)35(yps. )]TJ /T1_2 1 Tf 0.206 Tw 3.297 0 Td (Gastrointestinal Endosc.)Tj /T1_1 1 Tf [( 2009;69:278\226283. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1016/j.)Tj -3.297 -1.25 Td (gie.2008.04.066)Tj 0 0 0 1 k /GS1 gs 0.103 Tw T* (17.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Kimur)-32.9(a)]TJ /Span<>> BDC ( )Tj EMC [(T, Y)50(amamo)17.1(t)17(o)]TJ /Span<>> BDC ( )Tj EMC [(E, Y)50.1(amano)]TJ /Span<>> BDC ( )Tj EMC [(HO. A )0.5(novel pi)-24(t p)32(a)15(t)-30(ter)-15(n ident)-31.9(i)]TJ 0 Tw (-)Tj 0.072 Tw -1.796 -1.25 Td [(f)-28(ies t)-13(he p)25(r)-23.9(ecur)-10(sor of col)30(or)-23.9(ec)-16(t)15(al cancer der)-37(i)-15.9(ved fr)-32(om sessile ser)-24(r)-32.9(a)15(ted )]TJ 0 Tw T* (adenoma. )Tj /T1_2 1 Tf 0.089 Tw 4.25 0 Td [(Am )0.5(J )0.5(Gastroenterol.)]TJ /T1_1 1 Tf [( )0.5(2012;107\(3\):460\226469. )0.6(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw 19.648 0 Td (10.1038/)Tj -23.899 -1.25 Td (ajg.2011.457)Tj 0 0 0 1 k /GS1 gs -0.051 Tw T* (18.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(K)-16(a)15(t)17(o)]TJ /Span<>> BDC ( )Tj EMC 1.999 0 Td [(H, Ha)-17(ga)]TJ /Span<>> BDC ( )Tj EMC [(S, )0.5(End)-16(o)]TJ /Span<>> BDC ( )Tj EMC [(S, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. )0.5(L)-32(if)-28(t)-32(ing of )0.5(L)35(esions Dur)-37(ing )0.5(End)-16(oscopic )]TJ 0.02 Tw -3.795 -1.25 Td [(Mucosal R)13(esec)-16(t)-32(ion \(EMR\) of Ear)-30(l)35(y Col)30(or)-24(ec)-16(t)15(al Cancer: Im)10(pl)-31(ica)15(t)-32(ions for )]TJ 0.016 Tw T* [(t)-13(he Assess)26(ment of R)13(esec)-15.9(t)15(abil)-31(i)-24(t)-9.9(y. )]TJ /T1_2 1 Tf 0 Tw [(Endoscop)12(y)]TJ /T1_1 1 Tf 0.016 Tw (. 2001 Jul;33\(7\):568\22673. )Tj 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1055/s-2001-15308)Tj 0 0 0 1 k /GS1 gs 0.002 Tw -1.847 -1.25 Td (19.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Bur)-32(gess)]TJ /Span<>> BDC ( )Tj EMC 3.39 0 Td [(NG, )0.6(Bassan )0.5(Mil)-16(an)]TJ /Span<>> BDC ( )Tj EMC 6.986 0 Td [(S, )0.5(McL)35.1(eod, )0.5(e)-12(t)]TJ /Span<>> BDC ( )Tj EMC 5.347 0 Td [(al. )0.5(Deep )0.6(mur)-33(al )0.6(injur)-24(y )0.6(and )]TJ 0.051 Tw -17.52 -1.25 Td [(per)-24(for)-32.9(a)15(t)-32(ion af)-28(ter col)30(onic end)-15.9(oscopic mucosal r)-24(esec)-15.9(t)-32(ion: a new cl)-16(as)]TJ 0 Tw (-)Tj 0.122 Tw T* [(sif)-28(ica)15.1(t)-32(ion and anal)35(y)-13(sis of r)-36.9(isk f)16(a)-16.9(c)-16(t)17(or)-10(s. )]TJ /T1_2 1 Tf 0 Tw (Gut)Tj /T1_1 1 Tf 0.122 Tw [(. 2017 O)-16(c)-16(t;66\(10\):1779\226)]TJ 0.023 Tw T* [(1789. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1136/gutjnl-2015-309848)Tj 0 0 0 1 k /GS1 gs 0.126 Tw T* (20.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Hassan)Tj /Span<>> BDC ( )Tj EMC [(C, Ant)17(onell)-31(i)]TJ /Span<>> BDC ( )Tj EMC (G, Dumonceau)Tj /Span<>> BDC ( )Tj EMC [(JM, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. P)10(ost-pol)35(ypec)-16(t)17(omy )]TJ 0.008 Tc 0.349 Tw -1.796 -1.25 Td [(col)30.2(onoscopy sur)-31.7(veill)-15.7(ance: Eur)-31.7(opean S)-15.8(o)-15.8(c)-23.7(ie)-11.8(t)-9.8(y of Gastr)-31.7(ointest)-31.8(inal)8( )]TJ 0.004 Tc 0.35 Tw T* [(End)-16.1(oscopy )0.5(\(ESGE\) )0.5(Guidel)-31.1(ine)]TJ /Span<>> BDC ( )Tj EMC 12.71 0 Td [(\227 )0.5(U)12.9(pd)41.9(a)14.9(te 2020. )]TJ /T1_2 1 Tf -0.004 Tw 7.912 0 Td [(Endoscop)11.9(y)]TJ /T1_1 1 Tf 0.35 Tw [(. )0.5(2020)4( )]TJ 0 Tc 0.116 Tw -20.622 -1.25 Td [(A)10(ug;52\(8\):687\226700. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1055/a-1185-3109)Tj 0 0 0 1 k /GS1 gs 0.116 Tw ( Epub 2020 Jun 22. )Tj 0.023 Tw T* (PMID: 32572858.)Tj 0.008 Tw T* (21.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(P)-24(imentel-Nunes)]TJ /Span<>> BDC ( )Tj EMC [(P, L)-32(ib\342nio)]TJ /Span<>> BDC ( )Tj EMC [(D, Bast)-32(iaansen)]TJ /Span<>> BDC ( )Tj EMC [(BAJ, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. End)-16(oscopic )]TJ 0.011 Tc 0.395 Tw -1.796 -1.25 Td [(submucosal )0.6(dissec)-15.6(t)-31.6(ion )0.6(for )0.5(s)0.5(uper)-23.6(f)-27.6(ic)-23.6(ial )0.6(gastr)-31.6(ointest)-31.6(inal )0.6(lesions:)11( )]TJ 0 Tc 0.003 Tw T* [(Eur)-32(opean S)-16(o)-16(c)-23.9(ie)-12(t)-10(y of Gastr)-32(ointest)-31.9(inal End)-16(oscopy \(ESGE\) Guidel)-30.9(ine)]TJ /Span<>> BDC ( )Tj EMC (\227 )Tj 0.071 Tw T* [(U)13(pd)42(a)15(te 2022. )]TJ /T1_2 1 Tf 0 Tw [(Endoscop)12(y)]TJ /T1_1 1 Tf 0.071 Tw [(. 2022 Jun;54\(6\):591\226622. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1055/a-)Tj T* (1811-7025)Tj 0 0 0 1 k /GS1 gs 0.023 Tw [( Epub 2022 Ma)15(y 6. PMID: 35523224.)]TJ 0.04 Tw T* (22.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Bae)Tj /Span<>> BDC ( )Tj EMC [(JH, Y)50(ang)]TJ /Span<>> BDC ( )Tj EMC [(DH, L)35(ee)]TJ /Span<>> BDC ( )Tj EMC [(S, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Opt)-32(imized hybr)-37(id end)-16(oscopic sub)]TJ 0 Tw (-)Tj 0.145 Tw -1.796 -1.25 Td [(mucosal )0.6(dissec)-16(t)-32(ion )0.6(for )0.6(col)30(or)-24(ec)-16(t)15(al )0.6(tumor)-9.9(s: )0.5(a )0.6(r)-33(and)-16(omized )0.6(contr)-32(olled )]TJ 0 Tw T* [(tr)-37(ial. )]TJ /T1_2 1 Tf 0.16 Tw 2.394 0 Td (Gastrointest Endosc)Tj /T1_1 1 Tf [(. 2016 Mar;83\(3\):584\22692. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1016/j.)Tj -2.394 -1.25 Td (gie.2015.06.057)Tj 0 0 0 1 k /GS1 gs 0.023 Tw [( Epub 2015 A)10(ug 28. PMID: 26320696.)]TJ 0.198 Tw T* (23.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(F)10(ucc)-24(io)]TJ /Span<>> BDC ( )Tj EMC (L, Hassan)Tj /Span<>> BDC ( )Tj EMC [(C, P)10(onchon)]TJ /Span<>> BDC ( )Tj EMC [(T, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Cl)-31(inical outcomes af)-28(ter )]TJ 0.011 Tc 0.41 Tw -1.796 -1.25 Td [(end)-16(oscopic submucosal dissec)-16.1(t)-32(ion for col)29.9(or)-24(ec)-16(t)15(al neopl)-16(asia: a)11( )]TJ 0.002 Tc 0.35 Tw T* [(sy)-13.2(stema)14.8(t)-32.2(ic r)-24.2(ev)-16.2(iew and me)-12.2(t)14.8(a-anal)34.8(y)-13.2(sis. )]TJ /T1_2 1 Tf (Gastrointest Endosc.)Tj /T1_1 1 Tf [( 2017)2( )]TJ 0 Tc -0.028 Tw T* [(Jul;86\(1\):74\22686.e17. )0.5(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1016/j.gie.2017.02.024)Tj 0 0 0 1 k /GS1 gs -0.028 Tw [( Epub 2017 F)10(eb )]TJ 0.023 Tw T* (28. PMID: 28254526.)Tj 0.101 Tw T* (24.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Kim)Tj /Span<>> BDC ( )Tj EMC [(Y)15.1(J, Kim)]TJ /Span<>> BDC ( )Tj EMC (ES, Cho)Tj /Span<>> BDC ( )Tj EMC [(KB, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Com)10(p)32(ar)-37(ison of cl)-31(inical outcomes )]TJ 0.029 Tw -1.796 -1.25 Td [(among dif)-56(fer)-23.9(ent end)-16(oscopic r)-23.9(esec)-16(t)-32(ion me)-11.9(t)-13(hods for tr)-23.9(ea)15(t)-32(ing col)30(or)-24(ec)]TJ 0 Tw (-)Tj 0.148 Tw T* [(t)15(al neopl)-16(asia. )]TJ /T1_2 1 Tf (Dig Dis Sci.)Tj /T1_1 1 Tf [( 2013 Jun;58\(6\):1727\22636. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1007/)Tj T* (s10620-013-2560-x)Tj 0 0 0 1 k /GS1 gs 0.023 Tw [( Epub 2013 F)10(eb 6. PMID: 23385636.)]TJ 0.223 Tw T* (25.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Belder)-23.9(bos)]TJ /Span<>> BDC ( )Tj EMC [(TD, L)35(eender)-9.9(s)]TJ /Span<>> BDC ( )Tj EMC [(M, M)-24(o)-15.9(ons)]TJ /Span<>> BDC ( )Tj EMC [(LM, e)-11.9(t)]TJ /Span<>> BDC ( )Tj EMC [(al. L)34.9(o)-15.9(cal r)-23.9(ecur)-24(r)-24(ence )]TJ 0.14 Tw -1.796 -1.25 Td [(af)-28(ter end)-16(oscopic mucosal r)-24(esec)-16(t)-32(ion of non)10.9(peduncul)-15.9(a)15(ted col)30(or)-23.9(ec)-16(t)15(al )]TJ 0.007 Tc 0.349 Tw T* [(l)0.5(e)0.6(s)0.5(i)0.5(o)0.5(n)0.5(s)0.6(:)0.5( s)0.5(y)-12.4(s)0.5(t)0.5(e)0.5(m)0.6(a)15.5(t)-31.5(i)0.5(c)0.5( r)-23.5(e)0.6(v)-15.5(i)0.5(e)0.5(w)0.6( a)0.5(n)0.5(d)0.5( m)0.5(e)-11.5(t)15.6(a)0.5(-)0.5(a)0.5(n)0.5(a)0.6(l)35.5(y)-12.5(s)0.5(i)0.5(s)0.6(.)0.5( )]TJ /T1_2 1 Tf -0.007 Tw [(E)0.6(n)0.5(d)0.5(o)0.5(s)0.5(c)0.6(o)0.5(p)12.5(y)]TJ /T1_1 1 Tf 0.349 Tw 24.727 0 Td [(.)0.5( 2)0.5(0)0.5(1)0.5(4)7( )]TJ 0 Tc 0.169 Tw -24.727 -1.25 Td [(Ma)15(y;46\(5\):388\226402. )0.5(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1055/s-0034-1364970)Tj 0 0 0 1 k /GS1 gs 0.169 Tw [( )0.5(Epub 2014 Mar )]TJ 0.023 Tw T* (26. PMID: 24671869.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 0 Tw 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\033\030\031\030\213\b)-20.9(\035\231\213\233\t \021\032)50(\b)42(\032\231\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj /T1_3 1 Tf 25 0 0 25 511.9769 56.0378 Tm (31)Tj ET endstream endobj 2301 0 obj <>/Border[0 0 0]/H/N/Rect[57.2978 738.512 184.105 729.216]/Subtype/Link/Type/Annot>> endobj 2302 0 obj <>/Border[0 0 0]/H/N/Rect[115.614 708.512 209.086 699.216]/Subtype/Link/Type/Annot>> endobj 2303 0 obj <>/Border[0 0 0]/H/N/Rect[128.277 678.512 201.685 669.216]/Subtype/Link/Type/Annot>> endobj 2304 0 obj <>/Border[0 0 0]/H/N/Rect[57.2978 628.512 150.321 619.216]/Subtype/Link/Type/Annot>> endobj 2305 0 obj <>/Border[0 0 0]/H/N/Rect[126.916 588.512 198.164 579.216]/Subtype/Link/Type/Annot>> endobj 2306 0 obj <>/Border[0 0 0]/H/N/Rect[233.71 528.512 263.622 519.056]/Subtype/Link/Type/Annot>> endobj 2307 0 obj <>/Border[0 0 0]/H/N/Rect[42.5197 518.512 82.4875 509.216]/Subtype/Link/Type/Annot>> endobj 2308 0 obj <>/Border[0 0 0]/H/N/Rect[233.71 478.512 263.622 469.056]/Subtype/Link/Type/Annot>> endobj 2309 0 obj <>/Border[0 0 0]/H/N/Rect[42.5197 468.512 123.256 459.216]/Subtype/Link/Type/Annot>> endobj 2310 0 obj <>/Border[0 0 0]/H/N/Rect[57.2978 418.512 150.769 409.216]/Subtype/Link/Type/Annot>> endobj 2311 0 obj <>/Border[0 0 0]/H/N/Rect[168.728 388.512 256.311 379.056]/Subtype/Link/Type/Annot>> endobj 2312 0 obj <>/Border[0 0 0]/H/N/Rect[128.94 358.512 207.595 349.216]/Subtype/Link/Type/Annot>> endobj 2313 0 obj <>/Border[0 0 0]/H/N/Rect[73.716 328.512 152.372 319.216]/Subtype/Link/Type/Annot>> endobj 2314 0 obj <>/Border[0 0 0]/H/N/Rect[461.551 728.512 496.063 719.056]/Subtype/Link/Type/Annot>> endobj 2315 0 obj <>/Border[0 0 0]/H/N/Rect[274.961 718.512 328.032 709.216]/Subtype/Link/Type/Annot>> endobj 2316 0 obj <>/Border[0 0 0]/H/N/Rect[466.151 688.512 496.063 679.056]/Subtype/Link/Type/Annot>> endobj 2317 0 obj <>/Border[0 0 0]/H/N/Rect[274.961 678.512 317.632 669.216]/Subtype/Link/Type/Annot>> endobj 2318 0 obj <>/Border[0 0 0]/H/N/Rect[289.739 638.512 364.394 629.216]/Subtype/Link/Type/Annot>> endobj 2319 0 obj <>/Border[0 0 0]/H/N/Rect[310.157 598.512 405.116 589.216]/Subtype/Link/Type/Annot>> endobj 2320 0 obj <>/Border[0 0 0]/H/N/Rect[359.357 558.512 430.605 549.216]/Subtype/Link/Type/Annot>> endobj 2321 0 obj <>/Border[0 0 0]/H/N/Rect[459.631 508.512 496.063 499.056]/Subtype/Link/Type/Annot>> endobj 2322 0 obj <>/Border[0 0 0]/H/N/Rect[274.961 498.512 309.777 489.216]/Subtype/Link/Type/Annot>> endobj 2323 0 obj <>/Border[0 0 0]/H/N/Rect[461.551 468.512 496.063 459.056]/Subtype/Link/Type/Annot>> endobj 2324 0 obj <>/Border[0 0 0]/H/N/Rect[274.961 458.512 328.032 449.216]/Subtype/Link/Type/Annot>> endobj 2325 0 obj <>/Border[0 0 0]/H/N/Rect[360.481 418.512 448.065 409.216]/Subtype/Link/Type/Annot>> endobj 2326 0 obj <>/Border[0 0 0]/H/N/Rect[466.151 378.512 496.063 369.056]/Subtype/Link/Type/Annot>> endobj 2327 0 obj <>/Border[0 0 0]/H/N/Rect[274.961 368.512 338.072 359.216]/Subtype/Link/Type/Annot>> endobj 2328 0 obj <>/Border[0 0 0]/H/N/Rect[360.185 328.512 442.841 319.216]/Subtype/Link/Type/Annot>> endobj 2356 0 obj <> endobj 2355 0 obj <> endobj 2354 0 obj <> endobj 2353 0 obj <> endobj 2352 0 obj <> endobj 2351 0 obj <> endobj 2350 0 obj <> endobj 2349 0 obj <> endobj 2348 0 obj <> endobj 2347 0 obj <> endobj 2346 0 obj <> endobj 2345 0 obj <> endobj 2344 0 obj <> endobj 2343 0 obj <> endobj 2342 0 obj <> endobj 2341 0 obj <> endobj 2340 0 obj <> endobj 2339 0 obj <> endobj 2338 0 obj <> endobj 2337 0 obj <> endobj 2336 0 obj <> endobj 2335 0 obj <> endobj 2334 0 obj <> endobj 2333 0 obj <> endobj 2332 0 obj <> endobj 2331 0 obj <> endobj 2330 0 obj <> endobj 2329 0 obj <> endobj 2098 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 2099 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 2100 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 2101 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 2102 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 2362 0 obj [2364 0 R 2365 0 R 2366 0 R 2367 0 R 2368 0 R 2369 0 R 2370 0 R 2371 0 R 2372 0 R 2373 0 R 2374 0 R 2375 0 R 2376 0 R 2377 0 R 2378 0 R 2379 0 R 2380 0 R 2381 0 R 2382 0 R 2383 0 R 2384 0 R 2385 0 R 2386 0 R 2387 0 R 2388 0 R 2389 0 R 2390 0 R 2391 0 R 2392 0 R 2393 0 R 2394 0 R 2395 0 R 2396 0 R 2397 0 R 2398 0 R 2399 0 R 2400 0 R 2401 0 R 2402 0 R 2403 0 R] endobj 2363 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.012 Tc 0.428 Tw 8 0 0 8 70.8661 731.2159 Tm [(\n\036)0.5(\021\024\007\024\n \n\031\022\024)0.5(\220\022\021)0.5(\024\n\017\017)0.5(. )]TJ /T1_1 1 Tf -0.012 Tw [(\222)0.5(\n\023\n\033)0.5(\032\n\013\024)0.5(\n\023\n)0.5(\202\025\002.)]TJ /T1_0 1 Tf 0.428 Tw 19.081 0 Td [( 20)0.5(21;20)0.5(\(1\):)0.5(10\22616)0.5(.)12( )]TJ 0 Tc 0 Tw -19.081 -1.25 Td [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.33878/2073-7556-2021-20-1-10-16)Tj 0 0 0 1 k /GS1 gs 0.065 Tw -1.847 -1.25 Td (3.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(M)-24(oss)]TJ /Span<>> BDC ( )Tj EMC [(A, W)-16(ill)-30.9(iams SJ, Hour)-37(igan)]TJ /Span<>> BDC ( )Tj EMC [(LF, Br)-32(o)-13.9(wn G, e)-11.9(t)]TJ /Span<>> BDC ( )Tj EMC [(al. L)35(ong-ter)-16(m)]TJ /Span<>> BDC ( )Tj EMC (ade)Tj 0 Tw (-)Tj 0.267 Tw -1.296 -1.25 Td [(noma r)-24(ecur)-23.9(r)-24(ence foll)30.1(o)-14(wing wide-f)-28(ield end)-16(oscopic mucosal r)-23.9(esec)]TJ 0 Tw (-)Tj 0.282 Tw 0 -1.25 TD [(t)-32(ion \(WF-EMR\) for ad)-17(v)-15(anced col)30(onic mucosal neopl)-16(asia is infr)-23.9(e)]TJ 0 Tw (-)Tj 0.195 Tw T* [(quent: r)-23.9(esul)56(ts and r)-37(isk f)16(a)-17(c)-16(t)17(or)-9.9(s in 1000 cases fr)-31.9(om t)-13(he A)10(ustr)-33(al)-30.9(ian )]TJ 0.289 Tw T* [(Col)30(onic EMR )0.5(\(A)16(CE\) stud)17(y. )]TJ /T1_1 1 Tf 0 Tw (Gut)Tj /T1_0 1 Tf 0.289 Tw [(. 2015;64\(1\):57\22665. )0.5(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1136/)Tj T* (gutjnl-2013-305516)Tj 0 0 0 1 k /GS1 gs 0.01 Tc 0.356 Tw T* [(4)0.5(.)]TJ /Span<>> BDC 0.815 0 Td ( )Tj EMC 0.51 0 Td [(\214)0.5(\017)0.5(\022)0.5(\031)0.5(\021)0.5(\024\r)]TJ /Span<>> BDC 3.428 0 Td ( )Tj EMC [(\202)0.5(.)0.5(\202)0.5(.)0.5(,)0.5( \204)0.5(\021)0.5(\r)0.5(\030)0.5(\026)0.5(\035)0.5(\026)0.5(\001\r)0.6(\017\035)0.5(\017)]TJ /Span<>> BDC 9.323 0 Td ( )Tj EMC [(\212)0.5(.)0.5(\202)0.5(.)0.5(,)0.5( \203)0.5(\026)0.5(\020)0.5(\031)0.5(\007)0.5(\024)0.5(\r)]TJ /Span<>> BDC 6.596 0 Td ( )Tj EMC [(\204)0.5(.)0.5(\202)0.5(.)0.5(,)0.5( \017)]TJ /Span<>> BDC 3.77 0 Td ( )Tj EMC [(\f)0.5(\024)0.5(\026)0.5(\r)0.5(\021)0.5(.)10( )]TJ 0.014 Tc 0.515 Tw -24.442 -1.25 Td (\205\026\022\021\024\030\t, \035\017\n\017\021\017\030\031\033\013\017\036\ \r\t\023\024\035\027\036\027\017\036 \023\024\007\f\035\017\017\f\021\024\ \005 \007\017\f\f\036\022)Tj 0 Tc 0 Tw (-)Tj 0.012 Tc 0.457 Tw T* (\006\017\017 \r)Tj /Span<>> BDC ( )Tj EMC (\021\024\035\f\021\024\005 \022\017\001\022\036. )Tj /T1_1 1 Tf -0.012 Tw (\222\n\023\n\033\032\n\013\024\n\023\n\202\025\002.)Tj /T1_0 1 Tf 0.457 Tw [( 2021;20\(2\):50\22656.)12( )]TJ 0 Tc 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.33878/2073-7556-2021-20-2-50-56)Tj 0 0 0 1 k /GS1 gs 0.094 Tw -1.847 -1.25 Td (5.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (\202\002\007\031\035\032\026\035\017\036\r\026)Tj /Span<>> BDC ( )Tj EMC 6.319 0 Td [(\224.\211., )0.6(\214\017\022\031\021\024\r)]TJ /Span<>> BDC ( )Tj EMC 5.758 0 Td [(\202.\202., )0.6(\204\021\r\030\026\035\026\001\r\017\035\017)]TJ /Span<>> BDC ( )Tj EMC 8.617 0 Td [(\212.\202., )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC 3.098 0 Td (\f\024\026\r\021. )Tj 0.015 Tc 0.548 Tw -25.088 -1.25 Td (\215\030\017\n\036\027\036\027\017\036 \220\027\007\024\f\022\024\023\017\ \004\036\f\022\024\005 \030\036\036\022\006\017\017 \f\035\017\017\f\021\ \024\005 \024\002\024\035\024\004)Tj 0 Tc 0 Tw (-)Tj 0.009 Tc 0.352 Tw T* (\022\017 \f)Tj /Span<>> BDC ( )Tj EMC (\006\017\030\022\031\035\016\030\027\t\n \030\026\030\036\024\n \023\030\ \017)Tj /Span<>> BDC ( )Tj EMC [(\031\007\026\035\036\027\017\017 \027\024\r\024\024\002\030\026\024\r\026\ \027\017\005)9( )]TJ 0 Tc 0.232 Tw T* (\021\024\035\f\021\024\005 \022\017\001\022\017 \(\023\030\024\n\036\032\ \031\021\024\004\027\t\036 \030\036\031\035\034\021\026\021\t\). )Tj /T1_1 1 Tf 0 Tw (\222\n\023\n\033\032\n\013\024\n\023\n\202\025\002. )Tj /T1_0 1 Tf 0.023 Tw T* [(2022;21\(4\):21\22629. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.33878/2073-7556-2022-21-4-21-29)Tj 0 0 0 1 k /GS1 gs 0.154 Tw T* (6.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(T)40(akuji Go)17(t)17(od)42(a, Hir)-32(onor)-37(i Y)50(amamo)17(t)17(o, R)11(oy)]TJ /Span<>> BDC ( )Tj EMC [(M. S)-16(oe)-12(t)-32(ikno End)-16(oscopic )]TJ 0.019 Tw -1.296 -1.25 Td [(submucosal dissec)-16(t)-32(ion of ear)-30(l)35(y gastr)-37(ic cancer. )]TJ /T1_1 1 Tf (J Gastroenterol.)Tj /T1_0 1 Tf ( 2006; )Tj 0.023 Tw T* [(41\(10\), 929\226942. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1007/s00535-006-1954-3)Tj 0 0 0 1 k /GS1 gs 0.039 Tw T* (7.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(W)-16(inter)]TJ /Span<>> BDC ( )Tj EMC [(K, W\242od)42(ar)-32(czyk)]TJ /Span<>> BDC ( )Tj EMC [(M, W\242od)42.1(ar)-32(czyk)]TJ /Span<>> BDC ( )Tj EMC [(J, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. R)-24(isk S)15(tr)-33(a)15(t)-32(if)-27.9(ica)15(t)-32(ion of )]TJ 0.008 Tw -1.296 -1.25 Td [(End)-16(oscopic Submucosal Dissec)-15.9(t)-32(ion in Col)30(on T)60(umor)-10(s. )]TJ /T1_1 1 Tf (J Clin Med.)Tj /T1_0 1 Tf ( 2022 )Tj 0.281 Tw T* [(Mar 12;11\(6\):1560. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.3390/jcm11061560)Tj 0 0 0 1 k /GS1 gs 0.281 Tw ( PMID: 35329886; )Tj 0.023 Tw T* (PMCID: PMC8949025.)Tj 0.022 Tw T* (8.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Y)35(un Jung Kim, Eun S)-16(o)-16(o Kim, K)20(w)-12(ang Bum Cho, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Com)10(p)32(ar)-37(ison of )]TJ 0.149 Tw -1.296 -1.25 Td [(Cl)-31(inical Outcomes Among Dif)-56(fer)-24(ent End)-16(oscopic R)13(esec)-16(t)-32(ion Me)-12(t)-13(hods )]TJ 0.063 Tw T* [(for T)49.9(r)-23.9(ea)15(t)-32(ing Col)30(or)-24(ec)-16(t)15(al Neopl)-16(asia. )]TJ /T1_1 1 Tf (Clin Endosc)Tj /T1_0 1 Tf (. 2018;51\(3\):266\226273. )Tj 0 Tw 0 -1.25 Td [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1007/s10620-013-2560-x)Tj 0 0 0 1 k /GS1 gs 0.153 Tw -1.847 -1.25 Td (9.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Y)40(oshid)42(a)]TJ /Span<>> BDC ( )Tj EMC (N, Inoue)Tj /Span<>> BDC ( )Tj EMC (K, Dohi)Tj /Span<>> BDC ( )Tj EMC [(O, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Ef)-56(f)-28(ica)-16.9(cy of p)25(r)-24(ecut)-30(t)-32(ing end)-16(o)]TJ 0 Tw (-)Tj 0.004 Tw -1.296 -1.25 Td [(scopic )0.5(mucosal )0.5(r)-24(esec)-16(t)-31.9(ion wi)-24(t)-12.9(h full )0.5(or )0.5(p)32(ar)-22(t)-31.9(ial c)-24(ir)-31.9(cumfer)-24(ent)-31.9(ial inc)-23.9(ision )]TJ 0.185 Tw T* [(using )0.5(a snar)-24(e t)-31.9(ip for dif)-55.9(f)-28(icul)56(t col)30(or)-23.9(ec)-16(t)15(al lesions. )]TJ /T1_1 1 Tf 0 Tw 20.844 0 Td [(Endoscop)12.1(y)]TJ /T1_0 1 Tf 0.185 Tw (. 2019 )Tj 0.181 Tw -20.844 -1.25 Td [(Sep;51\(9\):871\226876. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1055/a-0956-6879)Tj 0 0 0 1 k /GS1 gs 0.181 Tw ( Epub 2019 Jul 15. )Tj 0.023 Tw T* (PMID: 31307100.)Tj 0.317 Tw T* (10.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Dong-Ho)-16(on Y)50(ang, Min-Seob K)20(w)-12(ak, Sang Hyoung P)40(ar)-24(k, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC (al. )Tj 0.014 Tc 0.52 Tw -1.796 -1.25 Td [(End)-16.1(oscopic Mucosal R)12.8(esec)-16.2(t)-32.1(ion wi)-24.2(t)-13.1(h Cir)-32.1(cumfer)-24.2(ent)-32.2(ial Mucosal)14.1( )]TJ 0.001 Tc 0.35 Tw T* [(Inc)-24.4(ision for Col)29.6(or)-24.4(ec)-16.4(t)14.6(al Neopl)-16.4(as)25.6(ms: Com)9.6(p)31.6(ar)-37.4(ison wi)-24.4(t)-13.3(h End)-16.4(oscopic)1( )]TJ 0 Tc -0.026 Tw T* [(Submucosal )0.6(Dissec)-16(t)-32(ion )0.6(and )0.6(be)-12(t)-32(ween )0.6(T)59.9(w)-13.9(o )0.5(End)-16(oscopists )0.6(wi)-24(t)-12.9(h )0.5(Dif)-56(fer)-23.9(ent )]TJ 0 Tw T* [(E)35(xper)-37(iences. )]TJ /T1_1 1 Tf 0.244 Tw 5.544 0 Td (Clin Endosc.)Tj /T1_0 1 Tf [( 2017 Jul;50\(4\):379\226387. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.5946/)Tj -5.544 -1.25 Td (ce.2016.058)Tj 0 0 0 1 k /GS1 gs 0.232 Tw T* (11.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(S)-16(hahini)]TJ /Span<>> BDC ( )Tj EMC [(E, P)40(asser)-33(a)]TJ /Span<>> BDC ( )Tj EMC [(R, L)35(o Secco)]TJ /Span<>> BDC ( )Tj EMC [(G, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. A sy)-12.9(stema)15(t)-32(ic r)-24(ev)-16(iew )]TJ 0.167 Tw -1.796 -1.25 Td [(and )0.6(me)-12(t)15(a-anal)35(y)-13(sis )0.6(of )0.6(end)-16(oscopic )0.6(mucosal )0.6(r)-24(esec)-16(t)-31.9(ion )0.5(vs )0.6(end)-16(oscopic )]TJ 0.197 Tw T* [(submucosal dissec)-15.9(t)-32(ion for col)30(or)-24(ec)-16(t)15(al sessile/non-pol)35.1(ypoid lesions. )]TJ /T1_1 1 Tf 0.026 Tw T* [(Minim In)11(v)16(asiv)13(e Ther Allied T)54(echnol.)]TJ /T1_0 1 Tf [( 2022 A)10(ug;31\(6\):835\226847. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10)Tj T* (.1080/13645706.2022.2032759)Tj 0 0 0 1 k /GS1 gs 0.023 Tw [( Epub 2022 F)10(eb 3. PMID: 35112654.)]TJ -0.002 Tw T* (12.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(L)35(ee Eun-Jung, L)35(ee Jae Bum, L)35(ee Suk Hee, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. End)-15.9(oscopic tr)-23.9(ea)15(t)]TJ 0 Tw (-)Tj 0.062 Tw -1.796 -1.25 Td [(ment of l)-15.9(ar)-32(ge col)30(or)-24(ec)-16(t)15.1(al tumor)-10(s: com)10(p)32(ar)-36.9(ison of end)-16(oscopic mucosal )]TJ -0.042 Tw T* [(r)-24(esec)-15.9(t)-32(ion, end)-15.9(oscopic mucosal r)-23.9(esec)-16(t)-32(ion\226p)25(r)-24(ecut)-29.9(t)-32(ing, and end)-16(oscopic )]TJ 0.086 Tw T* [(submucosal dissec)-16(t)-32(ion. )]TJ /T1_1 1 Tf [(Surgical Endoscop)12(y. )]TJ /T1_0 1 Tf 0 Tw (2012;26\(8\):2220\2262230. )Tj T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1007/s00464-012-2164-0)Tj 0 0 0 1 k /GS1 gs 0.002 Tw -1.847 -1.25 Td (13.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(R)13(en\351 L)-32(amber)-22(t, S)-16(hin ei K)25(ud)-15.9(o, Michael V)-14.9(ie)-12(t)-13(h, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. P)35(r)-33(a)-17(gma)15(t)-31.9(ic cl)-15.9(as)]TJ 0 Tw (-)Tj 0.208 Tw -1.796 -1.25 Td [(sif)-28(ica)15(t)-31.9(ion of )0.5(super)-24(f)-28(ic)-23.9(ial neopl)-15.9(ast)-32(ic col)30(or)-23.9(ec)-16(t)15(al )0.5(lesions. )]TJ /T1_1 1 Tf 0 Tw 22.911 0 Td (Gastrointest )Tj 6.144 62.5 Td (Endosc.)Tj /T1_0 1 Tf 0.023 Tw [( 2009 Dec;70\(6\):1182\22699. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1016/j.gie.2009.09.015)Tj 0 0 0 1 k /GS1 gs 0.011 Tc 0.424 Tw T* (14.)Tj /Span<>> BDC ( )Tj EMC 1.842 0 Td [(L)-32.4(amber)-22.4(t)]TJ /Span<>> BDC ( )Tj EMC 4.063 0 Td [(R, )0.5(e)-12.4(t)]TJ /Span<>> BDC ( )Tj EMC 2.924 0 Td [(al. )0.5(U)12.5(pd)41.6(a)14.6(te )0.5(on )0.5(t)-13.4(he )0.5(P)39.6(ar)-37.4(is )0.5(Cl)-16.4(assif)-28.4(ica)14.6(t)-32.4(ion )0.5(of)11.1( )]TJ 0 Tc 0.25 Tw -8.829 -1.25 Td [(Super)-23.9(f)-28(ic)-24(ial Neopl)-15.9(ast)-32(ic L)35(esions in t)-13(he Digest)-32(i)-16(ve T)50(r)-33(a)-17(c)-16(t. )]TJ /T1_1 1 Tf 0 Tw [(Endoscop)12.1(y)]TJ /T1_0 1 Tf (. )Tj 0.023 Tw T* [(2005;37\(6\):570\226578. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1055/s-2005-861352)Tj 0 0 0 1 k /GS1 gs -0.008 Tw T* (15.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(K)25(ud)-16(o)]TJ /Span<>> BDC ( )Tj EMC (S, Rubio)Tj /Span<>> BDC ( )Tj EMC 5.673 0 Td [(C)20(A, T)40(eix)12(eir)-32.9(a)]TJ /Span<>> BDC ( )Tj EMC [(CR, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. P)-23.9(i)-24(t p)32(a)15(t)-30(ter)-14.9(n in col)30(or)-24(ec)-16(t)15(al )0.5(neo)]TJ 0 Tw (-)Tj 0.252 Tw -7.469 -1.25 Td [(pl)-16(asia: end)-16(oscopic )0.5(ma)-17(gnif)-34(ying v)-16(iew. )]TJ /T1_1 1 Tf 0 Tw [(Endoscop)12.1(y)]TJ /T1_0 1 Tf 0.252 Tw (. 2001;33\(4\):367\226 )Tj 0.023 Tw T* [(373. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1055/s-2004-826104)Tj 0 0 0 1 k /GS1 gs 0.041 Tw T* (16.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Sano)Tj /Span<>> BDC ( )Tj EMC [(Y, Ik)10(ema)15(tsu)]TJ /Span<>> BDC ( )Tj EMC [(H, F)10(u)]TJ /Span<>> BDC ( )Tj EMC [(KI, e)-11.9(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Meshed capill)-15.9(ar)-24(y vessels b)12(y use )]TJ 0.008 Tw -1.796 -1.25 Td [(of nar)-24(r)-32(o)-14(w-band ima)-16.9(ging for dif)-55.9(fer)-24(ent)-32(ial dia)-17(gnosis of s)26(mall col)30(or)-24(ec)-16(t)15(al )]TJ 0 Tw T* [(pol)35(yps. )]TJ /T1_1 1 Tf 0.206 Tw 3.297 0 Td (Gastrointestinal Endosc.)Tj /T1_0 1 Tf [( 2009;69:278\226283. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1016/j.)Tj -3.297 -1.25 Td (gie.2008.04.066)Tj 0 0 0 1 k /GS1 gs 0.103 Tw T* (17.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Kimur)-32.9(a)]TJ /Span<>> BDC ( )Tj EMC [(T, Y)50(amamo)17.1(t)17(o)]TJ /Span<>> BDC ( )Tj EMC [(E, Y)50.1(amano)]TJ /Span<>> BDC ( )Tj EMC [(HO. A )0.5(novel pi)-24(t p)32(a)15(t)-30(ter)-15(n ident)-31.9(i)]TJ 0 Tw (-)Tj 0.072 Tw -1.796 -1.25 Td [(f)-28(ies t)-13(he p)25(r)-23.9(ecur)-10(sor of col)30(or)-23.9(ec)-16(t)15(al cancer der)-37(i)-15.9(ved fr)-32(om sessile ser)-24(r)-32.9(a)15(ted )]TJ 0 Tw T* (adenoma. )Tj /T1_1 1 Tf 0.089 Tw 4.25 0 Td [(Am )0.5(J )0.5(Gastroenterol.)]TJ /T1_0 1 Tf [( )0.5(2012;107\(3\):460\226469. )0.6(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw 19.648 0 Td (10.1038/)Tj -23.899 -1.25 Td (ajg.2011.457)Tj 0 0 0 1 k /GS1 gs -0.051 Tw T* (18.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(K)-16(a)15(t)17(o)]TJ /Span<>> BDC ( )Tj EMC 1.999 0 Td [(H, Ha)-17(ga)]TJ /Span<>> BDC ( )Tj EMC [(S, )0.5(End)-16(o)]TJ /Span<>> BDC ( )Tj EMC [(S, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. )0.5(L)-32(if)-28(t)-32(ing of )0.5(L)35(esions Dur)-37(ing )0.5(End)-16(oscopic )]TJ 0.02 Tw -3.795 -1.25 Td [(Mucosal R)13(esec)-16(t)-32(ion \(EMR\) of Ear)-30(l)35(y Col)30(or)-24(ec)-16(t)15(al Cancer: Im)10(pl)-31(ica)15(t)-32(ions for )]TJ 0.016 Tw T* [(t)-13(he Assess)26(ment of R)13(esec)-15.9(t)15(abil)-31(i)-24(t)-9.9(y. )]TJ /T1_1 1 Tf 0 Tw [(Endoscop)12(y)]TJ /T1_0 1 Tf 0.016 Tw (. 2001 Jul;33\(7\):568\22673. )Tj 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1055/s-2001-15308)Tj 0 0 0 1 k /GS1 gs 0.002 Tw -1.847 -1.25 Td (19.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Bur)-32(gess)]TJ /Span<>> BDC ( )Tj EMC 3.39 0 Td [(NG, )0.6(Bassan )0.5(Mil)-16(an)]TJ /Span<>> BDC ( )Tj EMC 6.986 0 Td [(S, )0.5(McL)35.1(eod, )0.5(e)-12(t)]TJ /Span<>> BDC ( )Tj EMC 5.347 0 Td [(al. )0.5(Deep )0.6(mur)-33(al )0.6(injur)-24(y )0.6(and )]TJ 0.051 Tw -17.52 -1.25 Td [(per)-24(for)-32.9(a)15(t)-32(ion af)-28(ter col)30(onic end)-15.9(oscopic mucosal r)-24(esec)-15.9(t)-32(ion: a new cl)-16(as)]TJ 0 Tw (-)Tj 0.122 Tw T* [(sif)-28(ica)15.1(t)-32(ion and anal)35(y)-13(sis of r)-36.9(isk f)16(a)-16.9(c)-16(t)17(or)-10(s. )]TJ /T1_1 1 Tf 0 Tw (Gut)Tj /T1_0 1 Tf 0.122 Tw [(. 2017 O)-16(c)-16(t;66\(10\):1779\226)]TJ 0.023 Tw T* [(1789. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1136/gutjnl-2015-309848)Tj 0 0 0 1 k /GS1 gs 0.126 Tw T* (20.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Hassan)Tj /Span<>> BDC ( )Tj EMC [(C, Ant)17(onell)-31(i)]TJ /Span<>> BDC ( )Tj EMC (G, Dumonceau)Tj /Span<>> BDC ( )Tj EMC [(JM, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. P)10(ost-pol)35(ypec)-16(t)17(omy )]TJ 0.008 Tc 0.349 Tw -1.796 -1.25 Td [(col)30.2(onoscopy sur)-31.7(veill)-15.7(ance: Eur)-31.7(opean S)-15.8(o)-15.8(c)-23.7(ie)-11.8(t)-9.8(y of Gastr)-31.7(ointest)-31.8(inal)8( )]TJ 0.004 Tc 0.35 Tw T* [(End)-16.1(oscopy )0.5(\(ESGE\) )0.5(Guidel)-31.1(ine)]TJ /Span<>> BDC ( )Tj EMC 12.71 0 Td [(\227 )0.5(U)12.9(pd)41.9(a)14.9(te 2020. )]TJ /T1_1 1 Tf -0.004 Tw 7.912 0 Td [(Endoscop)11.9(y)]TJ /T1_0 1 Tf 0.35 Tw [(. )0.5(2020)4( )]TJ 0 Tc 0.116 Tw -20.622 -1.25 Td [(A)10(ug;52\(8\):687\226700. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1055/a-1185-3109)Tj 0 0 0 1 k /GS1 gs 0.116 Tw ( Epub 2020 Jun 22. )Tj 0.023 Tw T* (PMID: 32572858.)Tj 0.008 Tw T* (21.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(P)-24(imentel-Nunes)]TJ /Span<>> BDC ( )Tj EMC [(P, L)-32(ib\342nio)]TJ /Span<>> BDC ( )Tj EMC [(D, Bast)-32(iaansen)]TJ /Span<>> BDC ( )Tj EMC [(BAJ, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. End)-16(oscopic )]TJ 0.011 Tc 0.395 Tw -1.796 -1.25 Td [(submucosal )0.6(dissec)-15.6(t)-31.6(ion )0.6(for )0.5(s)0.5(uper)-23.6(f)-27.6(ic)-23.6(ial )0.6(gastr)-31.6(ointest)-31.6(inal )0.6(lesions:)11( )]TJ 0 Tc 0.003 Tw T* [(Eur)-32(opean S)-16(o)-16(c)-23.9(ie)-12(t)-10(y of Gastr)-32(ointest)-31.9(inal End)-16(oscopy \(ESGE\) Guidel)-30.9(ine)]TJ /Span<>> BDC ( )Tj EMC (\227 )Tj 0.071 Tw T* [(U)13(pd)42(a)15(te 2022. )]TJ /T1_1 1 Tf 0 Tw [(Endoscop)12(y)]TJ /T1_0 1 Tf 0.071 Tw [(. 2022 Jun;54\(6\):591\226622. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1055/a-)Tj T* (1811-7025)Tj 0 0 0 1 k /GS1 gs 0.023 Tw [( Epub 2022 Ma)15(y 6. PMID: 35523224.)]TJ 0.04 Tw T* (22.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Bae)Tj /Span<>> BDC ( )Tj EMC [(JH, Y)50(ang)]TJ /Span<>> BDC ( )Tj EMC [(DH, L)35(ee)]TJ /Span<>> BDC ( )Tj EMC [(S, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Opt)-32(imized hybr)-37(id end)-16(oscopic sub)]TJ 0 Tw (-)Tj 0.145 Tw -1.796 -1.25 Td [(mucosal )0.6(dissec)-16(t)-32(ion )0.6(for )0.6(col)30(or)-24(ec)-16(t)15(al )0.6(tumor)-9.9(s: )0.5(a )0.6(r)-33(and)-16(omized )0.6(contr)-32(olled )]TJ 0 Tw T* [(tr)-37(ial. )]TJ /T1_1 1 Tf 0.16 Tw 2.394 0 Td (Gastrointest Endosc)Tj /T1_0 1 Tf [(. 2016 Mar;83\(3\):584\22692. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1016/j.)Tj -2.394 -1.25 Td (gie.2015.06.057)Tj 0 0 0 1 k /GS1 gs 0.023 Tw [( Epub 2015 A)10(ug 28. PMID: 26320696.)]TJ 0.198 Tw T* (23.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(F)10(ucc)-24(io)]TJ /Span<>> BDC ( )Tj EMC (L, Hassan)Tj /Span<>> BDC ( )Tj EMC [(C, P)10(onchon)]TJ /Span<>> BDC ( )Tj EMC [(T, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Cl)-31(inical outcomes af)-28(ter )]TJ 0.011 Tc 0.41 Tw -1.796 -1.25 Td [(end)-16(oscopic submucosal dissec)-16.1(t)-32(ion for col)29.9(or)-24(ec)-16(t)15(al neopl)-16(asia: a)11( )]TJ 0.002 Tc 0.35 Tw T* [(sy)-13.2(stema)14.8(t)-32.2(ic r)-24.2(ev)-16.2(iew and me)-12.2(t)14.8(a-anal)34.8(y)-13.2(sis. )]TJ /T1_1 1 Tf (Gastrointest Endosc.)Tj /T1_0 1 Tf [( 2017)2( )]TJ 0 Tc -0.028 Tw T* [(Jul;86\(1\):74\22686.e17. )0.5(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1016/j.gie.2017.02.024)Tj 0 0 0 1 k /GS1 gs -0.028 Tw [( Epub 2017 F)10(eb )]TJ 0.023 Tw T* (28. PMID: 28254526.)Tj 0.101 Tw T* (24.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Kim)Tj /Span<>> BDC ( )Tj EMC [(Y)15.1(J, Kim)]TJ /Span<>> BDC ( )Tj EMC (ES, Cho)Tj /Span<>> BDC ( )Tj EMC [(KB, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Com)10(p)32(ar)-37(ison of cl)-31(inical outcomes )]TJ 0.029 Tw -1.796 -1.25 Td [(among dif)-56(fer)-23.9(ent end)-16(oscopic r)-23.9(esec)-16(t)-32(ion me)-11.9(t)-13(hods for tr)-23.9(ea)15(t)-32(ing col)30(or)-24(ec)]TJ 0 Tw (-)Tj 0.148 Tw T* [(t)15(al neopl)-16(asia. )]TJ /T1_1 1 Tf (Dig Dis Sci.)Tj /T1_0 1 Tf [( 2013 Jun;58\(6\):1727\22636. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1007/)Tj T* (s10620-013-2560-x)Tj 0 0 0 1 k /GS1 gs 0.023 Tw [( Epub 2013 F)10(eb 6. PMID: 23385636.)]TJ 0.223 Tw T* (25.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Belder)-23.9(bos)]TJ /Span<>> BDC ( )Tj EMC [(TD, L)35(eender)-9.9(s)]TJ /Span<>> BDC ( )Tj EMC [(M, M)-24(o)-15.9(ons)]TJ /Span<>> BDC ( )Tj EMC [(LM, e)-11.9(t)]TJ /Span<>> BDC ( )Tj EMC [(al. L)34.9(o)-15.9(cal r)-23.9(ecur)-24(r)-24(ence )]TJ 0.14 Tw -1.796 -1.25 Td [(af)-28(ter end)-16(oscopic mucosal r)-24(esec)-16(t)-32(ion of non)10.9(peduncul)-15.9(a)15(ted col)30(or)-23.9(ec)-16(t)15(al )]TJ 0.007 Tc 0.349 Tw T* [(l)0.5(e)0.6(s)0.5(i)0.5(o)0.5(n)0.5(s)0.6(:)0.5( s)0.5(y)-12.4(s)0.5(t)0.5(e)0.5(m)0.6(a)15.5(t)-31.5(i)0.5(c)0.5( r)-23.5(e)0.6(v)-15.5(i)0.5(e)0.5(w)0.6( a)0.5(n)0.5(d)0.5( m)0.5(e)-11.5(t)15.6(a)0.5(-)0.5(a)0.5(n)0.5(a)0.6(l)35.5(y)-12.5(s)0.5(i)0.5(s)0.6(.)0.5( )]TJ /T1_1 1 Tf -0.007 Tw [(E)0.6(n)0.5(d)0.5(o)0.5(s)0.5(c)0.6(o)0.5(p)12.5(y)]TJ /T1_0 1 Tf 0.349 Tw 24.727 0 Td [(.)0.5( 2)0.5(0)0.5(1)0.5(4)7( )]TJ 0 Tc 0.169 Tw -24.727 -1.25 Td [(Ma)15(y;46\(5\):388\226402. )0.5(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1055/s-0034-1364970)Tj 0 0 0 1 k /GS1 gs 0.169 Tw [( )0.5(Epub 2014 Mar )]TJ 0.023 Tw T* (26. PMID: 24671869.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 70.936 201.1759 Tm (REFERENCES)Tj 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0 Tc 0.007 Tw 8 0 0 8 70.8661 188.3412 Tm (1.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(V)25(a)-17(ganov Y)35(u.E., Khomy)22(akov)]TJ /Span<>> BDC ( )Tj EMC [(E.A., Ser)-24(ebr)-37(iy)]TJ /Span<>> BDC ( )Tj EMC [(A.B., e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Mucosec)-16(t)17(omy )]TJ 0.168 Tw -1.296 -1.25 Td [(and tr)-33(adi)-23.9(t)-32(ional pol)35(ypec)-16(t)17(omy in t)-13(he tr)-24(ea)15.1(tment of col)30(on adenomas. )]TJ /T1_1 1 Tf 0 Tw T* [(K)18(olop)46(roktologia)]TJ /T1_0 1 Tf 0.039 Tw [(. 2021;20\(2\):29\22634. \(in Russ.\). )0.5(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.33878/2073-)Tj T* (7556-2021-20-2-29-34)Tj 0 0 0 1 k /GS1 gs 0.135 Tw T* (2.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(V)25(a)-17(ganov Y)35(u.E., V)30(esel)30(ov)]TJ /Span<>> BDC ( )Tj EMC [(V.V., L)-32(ikut)17.1(ov)]TJ /Span<>> BDC ( )Tj EMC [(A.A., e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. R)-24(isk f)16(a)-17(c)-16(t)17(or)-10(s for )]TJ 0.077 Tw -1.296 -1.25 Td [(r)-24(ecur)-23.9(r)-24(ence of col)30(on adenomas af)-27.9(ter t)-13(heir r)-23.9(emov)-15(al b)12(y mucosec)-16(t)17(omy. )]TJ /T1_1 1 Tf 0 Tw T* [(K)18(olop)46(roktologia)]TJ /T1_0 1 Tf 0.039 Tw [(. 2021;20\(1\):10\22616. \(in Russ.\). )0.5(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.33878/2073-)Tj T* (7556-2021-20-1-10-16)Tj 0 0 0 1 k /GS1 gs 0.243 Tw T* (3.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(M)-24(oss)]TJ /Span<>> BDC ( )Tj EMC [(A, W)-16(ill)-30.9(iams SJ, Hour)-36.9(igan)]TJ /Span<>> BDC ( )Tj EMC [(LF, Br)-32(o)-14(wn G, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al.. L)35(ong-ter)-16(m )]TJ 0.029 Tw -1.296 -1.25 Td [(adenoma r)-24(ecur)-24(r)-23.9(ence foll)30(o)-13.9(wing wide-f)-27.9(ield end)-16(oscopic mucosal r)-24(esec)]TJ 0 Tw (-)Tj 0.282 Tw T* [(t)-32(ion \(WF-EMR\) for ad)-17(v)-15(anced col)30(onic mucosal neopl)-16(asia is infr)-23.9(e)]TJ 0 Tw (-)Tj 0.195 Tw 29.055 12.5 Td [(quent: r)-23.9(esul)56(ts and r)-37(isk f)16(a)-17(c)-16(t)17(or)-9.9(s in 1000 cases )0.5(fr)-32(om t)-13(he A)10(ustr)-33(al)-30.9(ian )]TJ 0.289 Tw T* [(Col)30(onic EMR )0.5(\(A)16(CE\) )0.5(stud)17(y. )]TJ /T1_1 1 Tf 0 Tw (Gut.)Tj /T1_0 1 Tf 0.289 Tw [( 2015;64\(1\):57\22665. )0.5(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1136/)Tj T* (gutjnl-2013-305516)Tj 0 0 0 1 k /GS1 gs 0.272 Tw T* (4.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(L)-32(ikut)17.1(ov)]TJ /Span<>> BDC ( )Tj EMC [(A.A., Mt)-24(vr)-32.9(al)-16(ashv)-16(il)-30.9(i)]TJ /Span<>> BDC ( )Tj EMC [(D.A., Na)-17(gud)-16(ov)]TJ /Span<>> BDC ( )Tj EMC [(M.A., e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. F)20(a)-17(c)-16(t)17(or)-10(s )]TJ 0.224 Tw -1.296 -1.25 Td [(l)-31(imi)-23.9(t)-32(ing t)-12.9(he per)-24(for)-15.9(mance of submucosal dissec)-15.9(t)-32(ion in t)-13(he col)30(on. )]TJ /T1_1 1 Tf 0 Tw T* [(K)18(olop)46(roktologia)]TJ /T1_0 1 Tf 0.039 Tw [(. 2021;20\(2\):50\22656. \(in Russ.\). )0.5(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.33878/2073-)Tj T* (7556-2021-20-2-50-56)Tj 0 0 0 1 k /GS1 gs 0.201 Tw T* (5.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(A)-14(bdul)-39.9(zhal)-31(iev)-15(a)]TJ /Span<>> BDC ( )Tj EMC [(E.U., L)-32(ikut)17(ov)]TJ /Span<>> BDC ( )Tj EMC [(A.A., Mt)-23.9(vr)-33(al)-16(ashv)-15.9(il)-31(i)]TJ /Span<>> BDC ( )Tj EMC [(D.A., e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. T)47(he )]TJ 0.002 Tc 0.35 Tw -1.296 -1.25 Td [(use of end)-16.3(oscopic r)-24.2(esec)-16.2(t)-32.3(ion of t)-13.3(he mucous membr)-33.3(ane wi)-24.3(t)-13.2(h a)2( )]TJ 0 Tc 0.164 Tw T* [(c)-24(ir)-32(cul)-15.9(ar inc)-24(ision in t)-13(he r)-24(emov)-14.9(al of neopl)-16(as)26(ms of t)-13(he col)30(on \(inter)]TJ 0 Tw 27.286 0 Td (-)Tj 0.001 Tc 0.35 Tw -27.286 -1.25 Td [(media)14.8(te r)-24(esul)55.9(ts\). )]TJ /T1_1 1 Tf -0.001 Tw [(K)17.9(olop)45.8(roktologia)]TJ /T1_0 1 Tf 0.35 Tw [(. 2022;21\(4\):21\22629. )0.5(\(in Russ.\).)1( )]TJ 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0 Tc 0 Tw 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\033\030\031\030\213\b)-20.9(\035\231\213\233\t \021\032)50(\b)42(\032\231\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj -51.938 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 23, \023\0221)69(, 202)69(4)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 23, \023\0221)69(, 202)69(4)]TJ /T1_4 1 Tf 25 0 0 25 28.09 56.0378 Tm (30)Tj ET endstream endobj 2364 0 obj <>/Border[0 0 0]/H/N/Rect[85.6442 728.512 212.452 719.216]/Subtype/Link/Type/Annot>> endobj 2365 0 obj <>/Border[0 0 0]/H/N/Rect[262.057 678.512 291.968 669.056]/Subtype/Link/Type/Annot>> endobj 2366 0 obj <>/Border[0 0 0]/H/N/Rect[70.8661 668.512 135.914 659.216]/Subtype/Link/Type/Annot>> endobj 2367 0 obj <>/Border[0 0 0]/H/N/Rect[85.6442 628.512 212.452 619.216]/Subtype/Link/Type/Annot>> endobj 2368 0 obj <>/Border[0 0 0]/H/N/Rect[149.286 578.512 276.094 569.216]/Subtype/Link/Type/Annot>> endobj 2369 0 obj <>/Border[0 0 0]/H/N/Rect[143.961 548.512 237.432 539.216]/Subtype/Link/Type/Annot>> endobj 2370 0 obj <>/Border[0 0 0]/H/N/Rect[156.624 518.512 230.031 509.216]/Subtype/Link/Type/Annot>> endobj 2371 0 obj <>/Border[0 0 0]/H/N/Rect[85.6442 468.512 178.668 459.216]/Subtype/Link/Type/Annot>> endobj 2372 0 obj <>/Border[0 0 0]/H/N/Rect[155.263 428.512 226.51 419.216]/Subtype/Link/Type/Annot>> endobj 2373 0 obj <>/Border[0 0 0]/H/N/Rect[262.057 368.512 291.968 359.056]/Subtype/Link/Type/Annot>> endobj 2374 0 obj <>/Border[0 0 0]/H/N/Rect[70.8661 358.512 110.834 349.216]/Subtype/Link/Type/Annot>> endobj 2375 0 obj <>/Border[0 0 0]/H/N/Rect[283.968 318.512 291.968 309.056]/Subtype/Link/Type/Annot>> endobj 2376 0 obj <>/Border[0 0 0]/H/N/Rect[70.8661 308.512 173.514 299.216]/Subtype/Link/Type/Annot>> endobj 2377 0 obj <>/Border[0 0 0]/H/N/Rect[85.6442 258.512 179.116 249.216]/Subtype/Link/Type/Annot>> endobj 2378 0 obj <>/Border[0 0 0]/H/N/Rect[429.515 738.512 517.099 729.056]/Subtype/Link/Type/Annot>> endobj 2379 0 obj <>/Border[0 0 0]/H/N/Rect[389.727 708.512 468.383 699.216]/Subtype/Link/Type/Annot>> endobj 2380 0 obj <>/Border[0 0 0]/H/N/Rect[334.503 678.512 413.159 669.216]/Subtype/Link/Type/Annot>> endobj 2381 0 obj <>/Border[0 0 0]/H/N/Rect[489.898 648.512 524.409 639.056]/Subtype/Link/Type/Annot>> endobj 2382 0 obj <>/Border[0 0 0]/H/N/Rect[303.307 638.512 356.379 629.216]/Subtype/Link/Type/Annot>> endobj 2383 0 obj <>/Border[0 0 0]/H/N/Rect[494.498 608.512 524.409 599.056]/Subtype/Link/Type/Annot>> endobj 2384 0 obj <>/Border[0 0 0]/H/N/Rect[303.307 598.512 345.979 589.216]/Subtype/Link/Type/Annot>> endobj 2385 0 obj <>/Border[0 0 0]/H/N/Rect[318.085 558.512 392.741 549.216]/Subtype/Link/Type/Annot>> endobj 2386 0 obj <>/Border[0 0 0]/H/N/Rect[338.503 518.512 433.463 509.216]/Subtype/Link/Type/Annot>> endobj 2387 0 obj <>/Border[0 0 0]/H/N/Rect[387.704 478.512 458.951 469.216]/Subtype/Link/Type/Annot>> endobj 2388 0 obj <>/Border[0 0 0]/H/N/Rect[487.978 428.512 524.409 419.056]/Subtype/Link/Type/Annot>> endobj 2389 0 obj <>/Border[0 0 0]/H/N/Rect[303.307 418.512 338.123 409.216]/Subtype/Link/Type/Annot>> endobj 2390 0 obj <>/Border[0 0 0]/H/N/Rect[489.898 388.512 524.409 379.056]/Subtype/Link/Type/Annot>> endobj 2391 0 obj <>/Border[0 0 0]/H/N/Rect[303.307 378.512 356.379 369.216]/Subtype/Link/Type/Annot>> endobj 2392 0 obj <>/Border[0 0 0]/H/N/Rect[388.828 338.512 476.411 329.216]/Subtype/Link/Type/Annot>> endobj 2393 0 obj <>/Border[0 0 0]/H/N/Rect[494.498 298.512 524.409 289.056]/Subtype/Link/Type/Annot>> endobj 2394 0 obj <>/Border[0 0 0]/H/N/Rect[303.307 288.512 366.419 279.216]/Subtype/Link/Type/Annot>> endobj 2395 0 obj <>/Border[0 0 0]/H/N/Rect[388.532 248.512 471.188 239.216]/Subtype/Link/Type/Annot>> endobj 2396 0 obj <>/Border[0 0 0]/H/N/Rect[239.241 175.637 291.968 166.181]/Subtype/Link/Type/Annot>> endobj 2397 0 obj <>/Border[0 0 0]/H/N/Rect[70.8661 165.637 144.946 156.341]/Subtype/Link/Type/Annot>> endobj 2398 0 obj <>/Border[0 0 0]/H/N/Rect[239.241 135.637 291.968 126.181]/Subtype/Link/Type/Annot>> endobj 2399 0 obj <>/Border[0 0 0]/H/N/Rect[70.8661 125.637 144.946 116.341]/Subtype/Link/Type/Annot>> endobj 2400 0 obj <>/Border[0 0 0]/H/N/Rect[494.498 185.637 524.409 176.181]/Subtype/Link/Type/Annot>> endobj 2401 0 obj <>/Border[0 0 0]/H/N/Rect[303.307 175.637 368.355 166.341]/Subtype/Link/Type/Annot>> endobj 2402 0 obj <>/Border[0 0 0]/H/N/Rect[471.682 145.637 524.409 136.181]/Subtype/Link/Type/Annot>> endobj 2403 0 obj <>/Border[0 0 0]/H/N/Rect[303.307 135.637 377.387 126.341]/Subtype/Link/Type/Annot>> endobj 2443 0 obj <> endobj 2442 0 obj <> endobj 2441 0 obj <> endobj 2440 0 obj <> endobj 2439 0 obj <> endobj 2438 0 obj <> endobj 2437 0 obj <> endobj 2436 0 obj <> endobj 2435 0 obj <> endobj 2434 0 obj <> endobj 2433 0 obj <> endobj 2432 0 obj <> endobj 2431 0 obj <> endobj 2430 0 obj <> endobj 2429 0 obj <> endobj 2428 0 obj <> endobj 2427 0 obj <> endobj 2426 0 obj <> endobj 2425 0 obj <> endobj 2424 0 obj <> endobj 2423 0 obj <> endobj 2422 0 obj <> endobj 2421 0 obj <> endobj 2420 0 obj <> endobj 2419 0 obj <> endobj 2418 0 obj <> endobj 2417 0 obj <> endobj 2416 0 obj <> endobj 2415 0 obj <> endobj 2414 0 obj <> endobj 2413 0 obj <> endobj 2412 0 obj <> endobj 2411 0 obj <> endobj 2410 0 obj <> endobj 2409 0 obj <> endobj 2408 0 obj <> endobj 2407 0 obj <> endobj 2406 0 obj <> endobj 2405 0 obj <> endobj 2404 0 obj <> endobj 2360 0 obj [2444 0 R 2445 0 R] endobj 2361 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\235\001\201\025\006\n)10(\025\221\220\017\016\006\n\013\205 \024\215\n)10(\025)21(\222)21(\232\n)-9.9(\026)11(\025\024\220\205 \006\022\227\220\002\n\215\007\205\002\001\020\024 \002\ \013\222\002\016\222\025\024 )]TJ 0 -1 TD [(\006)-10(\007\220\222\220\006)-9.9(\026)11(\025\203 \025\f\025\007\025\017\n\220 \r\022\007\016\017\016\001\220\220\ \025\221\215)21.1(\207\025\007\016\203 \025\f\025\201\025\017\001\025\203 \n\220\n\220. )]TJ T* [(\033\016\222)21(\215\007\216)21(\026)11(\013\026\020 \002\013\001\201\025\024\220\222\220\002\025\r\013\001\001\025\ \202)10(\025 \220\006\006)-10(\007\016\201\025\r\013\001\220\205.)]TJ 34.507 2 Td [(Endoscopic mucosal r)31(esection with a cir)31(cumfer)31.1(ential incision in th)11(e )]TJ 2.851 -1 Td [(r)31(emov)10(al of colon neoplasms. Results of a r)21(andomiz)10.1(ed trial.)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0.047 Tw 10 0 0 10 42.5197 724.8299 Tm (\021\024\035\f\021\024\005 \022\017\001\022\017 \002\t\035\026 \r\t\023\024\ \035\027\036\027\026 \n\031\022\024\220\022\021\024\n\017\016)Tj /Span<>> BDC ( )Tj EMC (\227 \004\026)Tj 0 Tw (-)Tj 0.172 Tw 0 -1.218 TD (\f\021\024\021\026 \030\036\006\017\007\017\r\024\r \002\t\035\026 \027\ \026\004\017\021\036\035\034\027\024 \027\017\032\036 \023\024\f\035\036\ \220\027)Tj 0 Tw (-)Tj 0.11 Tw T* (\007\024\f\022\024\023\017\004\036\f\022\024\005 \030\036\036\022\006\017\ \017 \036\007\017\027\t\n \002\035\024\022\024\n, \004\036\n \023\024\f\035\ \036 )Tj -0.011 Tw T* (\235\030\026\020\n\036\027\021\026\030\027\024\020\024 \031\007\026\035\036\ \027\017\016)Tj /Span<>> BDC ( )Tj EMC (\227 \r)Tj /Span<>> BDC ( )Tj EMC (3% \017)Tj /Span<>> BDC ( )Tj EMC (20% \f\035\031\004\026\036\r, \f\024)Tj 0 Tw (-)Tj 0.086 Tw T* (\024\021\r\036\021\f\021\r\036\027\027\024 \()Tj /T1_2 1 Tf 0 Tw (\032)Tj /T1_1 1 Tf 0.086 Tw /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (0,0001\) [25]. \204\036\021\024\007\t C-EMR \017)Tj /Span<>> BDC ( )Tj EMC (ESD )Tj 0.078 Tw T* (\023\030\024\007\036\n\024\027\f\021\030\017\030\024\r\026\035\017 \b\024\ \030\024\001\017\036 \030\036\031\035\034\021\026\021\t \r)Tj /Span<>> BDC ( )Tj EMC (\024\021\027\024\001\036)Tj 0 Tw (-)Tj 0.099 Tw 0 -1.218 TD (\027\017\017 \030\026\007\017\022\026\035\034\027\024\f\021\017 \031\007\ \026\035\036\027\017\016 \027\024\r\024\024\002\030\026\024\r\026\027\017\ \005 \024\002\024)Tj 0 Tw (-)Tj 0 -1.218 TD (\007\024\004\027\024\005 \022\017\001\022\017.)Tj 0.06 Tw T* [(\202\027\026\035\017 )0.6(\030\036\031\035\034\021\026\021\024\r )0.5(\023\026\021\024\n\024\030\235\024\035\024\020\017\004\036\f\022\024\020\ \024 )0.5(\017\f\f\035\036\007\024)]TJ 0 Tw (-)Tj -0.012 Tw T* (\r\026\027\017\016 \024\023\036\030\026\006\017\024\027\027\t\b \023\030\ \036\023\026\030\026\021\024\r \r)Tj /Span<>> BDC ( )Tj EMC (\027\026\001\036\n \017\f\f\035\036\007\024\r\026)Tj 0 Tw (-)Tj -0.01 Tw T* (\027\017\017 \023\024\r\024\035\016\036\021 \f\007\036\035\026\021\034 \ \r\t\r\024\007, \004\021\024 \n\036\021\024\007 ESD \027\036\f\022\024\035\ \034)Tj 0 Tw (-)Tj 0.002 Tw T* [(\022\024 )0.5(\023\030\036\r\024\f\b\024\007\017\021 )0.6(\r)]TJ /Span<>> BDC ( )Tj EMC 7.356 0 Td [(\024\021\027\024\001\036\027\017\017 )0.6(\007\024\f\021\017\032\036\027\017\016 )0.5(\027\036\020\026\021\017\r\027\t\b )]TJ 0.147 Tw -7.356 -1.218 Td [(\020\030\026\027\017\006 \030\036\036\022\006\017\017 )0.5(\n\036\021\024\007\017\022\031 )0.5(C-EMR \023\030\017)]TJ /Span<>> BDC ( )Tj EMC 16.492 0 Td [(\031\007\026\035\036\027\017\017 )0.5(\007\024)]TJ 0 Tw (-)Tj 0.408 Tw -16.492 -1.218 Td (\002\030\024\022\026\004\036\f\021\r\036\027\027\t\b \220\023\017\021\036\ \035\017\026\035\034\027\t\b \027\024\r\024\024\002\030\026\024\r\026\027\ \017\005 )Tj 0.141 Tw T* [(\030\026\n\036\030\026\n\017 \024\021 20 )0.5(\n\n \007\024)]TJ /Span<>> BDC ( )Tj EMC [(30 \n\n. \210\007\027\026\022\024 \030\026\035\017\004\017\016 )0.5(\027\036 )]TJ 0.131 Tw T* [(\007\024\f\021\017\020\035\017 \f\021\026\021\017\f\021\017\004\036\f\022\ \024\005 )0.5(\027\026\004\017\n\024\f\021\017. \203\026)]TJ /Span<>> BDC ( )Tj EMC (\024\f\027\024\r\026\027\017\017 )Tj 0.173 Tw T* [(\030\036\031\035\034\021\026\021\024\r )0.6(\023\030\024\r\036\007\036\027\027\024\020\024 )0.6(\030\026\027\007\024\n\017\017\030\024\r\026\027\027\024\020\024 )0.5(\017\f)]TJ 0 Tw (-)Tj 0.004 Tw T* [(\f\035\036\007\024\r\026\027\017\016 )0.6(\002\t\035\024 )0.5(\031\f\021\026\027\024\r\035\036\027\024, )0.5(\004\021\024 )0.6(\031\007\026\035\036\027\017\036 )0.5(\022\030\031\023\027\t\b )]TJ 0.787 Tw T* (\007\024\002\030\024\022\026\004\036\f\021\r\036\027\027\t\b \027\024\r\024\ \024\002\030\026\024\r\026\027\017\005 \024\002\024\007\024\004\027\024\ \005 )Tj 0.236 Tw T* (\022\017\001\022\017 \n\036\021\024\007\024\n C-EMR \021\030\036\002\024\ \r\026\035\024 \r)Tj /Span<>> BDC ( )Tj EMC (2 \030\026\026 \n\036\027\034\001\036 )Tj 0.273 Tw T* (\r\030\036\n\036\027\017, \004\036\n \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\017\f\023\024\035\034\024\r\026\027\017\017 \n\036\021\024\007\026 \220\ \027\007\024\f\022\024)Tj 0 Tw (-)Tj 0.177 Tw T* (\023\017\004\036\f\022\024\005 \023\024\007\f\035\017\017\f\021\024\005\ \007\017\f\f\036\022\006\017\017)Tj /Span<>> BDC ( )Tj EMC (\227 30 \017)Tj /Span<>> BDC ( )Tj EMC (60 \n\017\027, )Tj 0.256 Tw T* (\f\024\024\021\r\036\021\f\021\r\036\027\027\024 \()Tj /T1_2 1 Tf 0 Tw (\032)Tj /T1_1 1 Tf 0.256 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,001\). \212\026\027\027\t\005 \r\t\r\024\007 \022\024\030\030\036)Tj 0 Tw (-)Tj 0.171 Tw T* (\f\023\024\027\007\017\030\031\036\021 \f)Tj /Span<>> BDC ( )Tj EMC (\030\036\031\035\034\021\026\021\026\n\017 \030\026\027\036\036 \r\t\023\ \024\035\027\036\027\027\t\b \027\036)Tj 0 Tw (-)Tj T* (\030\026\027\007\024\n\017\017\030\024\r\026\027\027\t\b \017\f\f\035\036\ \007\024\r\026\027\017\005 [9,22].)Tj 0.179 Tw T* (\203\036\f\n\024\021\030\016 \027\026)Tj /Span<>> BDC ( )Tj EMC (\021\024, \004\021\024 \021\026\022\024\005 \n\036\021\024\007 \220\027\007\ \024\f\022\024\023\017\004\036\f\022\024\020\024 )Tj 0.211 Tw T* (\031\007\026\035\036\027\017\016 \024\023\031\b\024\035\036\005 \021\024\ \035\f\021\024\005 \022\017\001\022\017, \022\026\022)Tj /Span<>> BDC ( )Tj EMC (\227 ESD, \024\021)Tj 0 Tw (-)Tj 0.13 Tw T* (\035\017\004\026\036\021\f\016 \002\024\035\036\036 \r\t\f\024\022\024\005\ \004\026\f\021\024\021\024\005 \030\036\036\022\006\017\017 \036\007\017\ \027\t\n )Tj 0.274 Tw T* (\002\035\024\022\024\n \r)Tj /Span<>> BDC ( )Tj EMC (\f\030\026\r\027\036\027\017\017 \f)Tj /Span<>> BDC ( )Tj EMC (\n\031\022\024\220\022\021\024\n\017\036\005, \021\036\n \027\036 \n\036\ )Tj 0 Tw (-)Tj 0.17 Tw T* (\027\036\036, \007\026\027\027\026\016 \021\036\b\027\017\022\026 \r\f\036\ \036\013\036 \027\036 \016\r\035\016\036\021\f\016 \030\031\021\017\027\ \027\024\005 )Tj 0.011 Tw T* (\023\030\017)Tj /Span<>> BDC ( )Tj EMC (\031\007\026\035\036\027\017\017 \022\030\031\023\027\t\b \027\024\r\024\ \024\002\030\026\024\r\026\027\017\005 \032\036\035\031\007\024\004\027\ \024-)Tj 0 Tw T* (\022\017\001\036\004\027\024\020\024 \021\030\026\022\021\026.)Tj 0.335 Tw T* (\203\036\f\n\024\021\030\016 \027\026)Tj /Span<>> BDC ( )Tj EMC (\023\030\036\017\n\031\013\036\f\021\r\026 \220\027\007\024\f\022\024\023\ \017\004\036\f\022\024\005 \007\017\f)Tj 0 Tw (-)Tj 0.016 Tw T* (\f\036\022\006\017\017 \r)Tj /Span<>> BDC ( )Tj EMC (\023\024\007\f\035\017\017\f\021\024\n \f\035\024\036, \024\002\031\f\035\ \024\r\035\036\027\027\t\036, \023\030\036\032\007\036 )Tj 0.204 Tw T* (\r\f\036\020\024, \r\024\n\024\032\027\024\f\021\034\033 \023\024\f\021\ \024\016\027\027\024\020\024 \022\024\027\021\030\024\035\016 \020\030\026\ \027\017\006 )Tj 0.084 Tw T* (\030\036\036\022\006\017\017 \r\024 \r\030\036\n\016 \023\030\024\006\036\ \007\031\030\t, \024\027\026 \023\030\024\017\020\030\t\r\026\036\021 \n\ \036)Tj 0 Tw (-)Tj 0.302 Tw T* (\021\024\007\031 \220\027\007\024\f\022\024\023\017\004\036\f\022\024\005\ \030\036\036\022\006\017\017 \f\035\017\017\f\021\024\005 \f)Tj /Span<>> BDC ( )Tj EMC (\006\017\030)Tj 0 Tw (-)Tj 0.205 Tw T* (\022\031\035\016\030\027\t\n \030\026\030\036\024\n \r)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\f\021\024\021\036 \017\f\023\024\035\027\036\027\017\016, \021\ \030\036\002\031\016 )Tj 0.115 Tw T* [(\r\t\f\024\022\024\020\024 \031\030\024\r\027\016 \022\r\026\035\017\235\ \017\022\026\006\017\017 )0.5(\024\023\036\030\017\030\031\033\013\036\020\024 )0.5(\r\030\026)]TJ 0 Tw (-)Tj 0.309 Tw T* (\004\026-\220\027\007\024\f\022\024\023\017\f\021\026, \024\f\024\002\036\ \027\027\024 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\031\007\026\035\036\027\017\017 \022\030\031\023\027\t\b )Tj 0 Tw T* (\027\024\r\024\024\002\030\026\024\r\026\027\017\005 \021\024\035\f\021\ \024\005 \022\017\001\022\017.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 42.5896 201.1758 Tm [(\020)21(\026\027\r\242\224\034\022\031\034)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0 Tc 0.266 Tw 10 0 0 10 42.5197 176.8198 Tm (\210\023\017\030\026\016\f\034 \027\026)Tj /Span<>> BDC ( )Tj EMC (\030\036\031\035\034\021\026\021\t \023\030\024\r\036\007\036\027\027\024\ \020\024 \030\026\027\007\024\n\017\017)Tj 0 Tw (-)Tj 0.075 Tw T* (\030\024\r\026\027\027\024\020\024 \017\f\f\035\036\007\024\r\026\027\017\ \016, \n\024\032\027\024 \031\021\r\036\030\032\007\026\021\034, \004\021\ \024 \220\027)Tj 0 Tw (-)Tj 0.237 Tw T* [(\007\024\f\022\024\023\017\004\036\f\022\026\016 \030\036\036\022\006\017\ \016 )0.5(\f\035\017\017\f\021\024\005 \f)]TJ /Span<>> BDC ( )Tj EMC (\006\017\030\022\031\035\016\030\027\t\n )Tj 0.588 Tw 23.244 57.237 Td (\030\026\030\036\024\n \n\024\032\036\021 \002\t\021\034 \026\035\034\021\ \036\030\027\026\021\017\r\024\005 \007\017\f\f\036\022\006\017\017 )Tj 0.087 Tw 0 -1.218 TD (\r)Tj /Span<>> BDC ( )Tj EMC (\023\024\007\f\035\017\017\f\021\024\n \f\035\024\036 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\031\007\026\035\036\027\017\017 \007\024\002\030\024\022\026\004\036\f\021\ \r\036\027)Tj 0 Tw (-)Tj 0.574 Tw 0 -1.218 TD (\027\t\b \220\023\017\021\036\035\017\026\035\034\027\t\b \027\024\r\024\ \024\002\030\026\024\r\026\027\017\005 \024\002\024\007\024\004\027\024\ \005 )Tj -0.025 Tw 0 -1.218 TD (\022\017\001\022\017 \030\026\n\036\030\024\n \024\021 20 \n\n \007\024\ )Tj /Span<>> BDC ( )Tj EMC (30 \n\n, \r\r\017\007\031 \f\r\024\036\005 \002\036\024)Tj 0 Tw (-)Tj 0.013 Tw 0 -1.218 TD (\023\026\f\027\024\f\021\017 \017)Tj /Span<>> BDC ( )Tj EMC (\220\235\235\036\022\021\017\r\027\024\f\021\017. \025\030\024\n\036 \021\ \024\020\024, \r\026\032\027\t\n \023\030\036)Tj 0 Tw (-)Tj 0.27 Tw 0 -1.218 TD (\017\n\031\013\036\f\021\r\024\n \n\036\021\024\007\017\022\017 C-EMR \016\ \r\035\016\036\021\f\016 \f\024\022\030\026\013\036\027\017\036 )Tj 0.235 Tw 0 -1.218 TD (\r)Tj /Span<>> BDC ( )Tj EMC (2 \030\026\026 \023\030\024\007\024\035\032\017\021\036\035\034\027\024\ \f\021\017 \024\023\036\030\026\021\017\r\027\024\020\024 \r\n\036\001\026\ )Tj 0 Tw (-)Tj 0.135 Tw 0 -1.218 TD (\021\036\035\034\f\021\r\026 \r)Tj /Span<>> BDC ( )Tj EMC (\f\030\026\r\027\036\027\017\017 \f)Tj /Span<>> BDC ( )Tj EMC (\220\027\007\024\f\022\024\023\017\004\036\f\022\024\005 \023\024\007\f\035\ \017\017)Tj 0 Tw (-)Tj 0.102 Tw T* [(\f\021\024\005 )0.5(\007\017\f\f\036\022\006\017\036\005 )0.5(\023\030\017)]TJ /Span<>> BDC ( )Tj EMC 9.185 0 Td [(\f\024\023\024\f\021\026\r\017\n\024\n )0.6(\022\026\004\036\f\021\r\036 )0.5(\024\023\036\030\026)]TJ 0 Tw (-)Tj -9.185 -1.218 Td (\006\017\024\027\027\024\020\024 \023\030\036\023\026\030\026\021\026.)Tj /T1_4 1 Tf 0.023 Tw 0 -2.436 TD (\223\030\032\255\020\034\036 \032\026\020\017\022\017\026)Tj /T1_1 1 Tf 0.006 Tc -0.006 Tw 0 -1.218 TD [(\025)1.9(\024)1.7(\027)7.7(\006\036)-0.8(\023)8.2(\006\017)0.5(\016)6( \017)]TJ /Span<>> BDC 5.324 0 Td ( )Tj EMC [(\007\017)8.7()-3.9(\026)5.7(\005)7.7(\027)19.2(:)]TJ /T1_2 1 Tf -0.01 Tc 0.01 Tw 3.46 0 Td [( \207)17.6(\205)-0.7(\001)-2.8(\013\n\027)]TJ /Span<>> BDC 3.159 0 Td ( )Tj EMC [(\255)17.6(.)19.3(\215)18.9(.)-2.2(,)-10( \224)2.2(\031)-10.9(\032)-4.6(\021)-2.3(\020\001)-6.7(\n\027)]TJ /Span<>> BDC 6.553 0 Td ( )Tj EMC [(\207)-12.1(.)18.5(\216)14.3(.)]TJ /T1_1 1 Tf 0 Tc 0.392 Tw -18.496 -1.218 Td [(\221)-4.6(\002)-9.9(\024)0.7(\030 \017)]TJ /Span<>> BDC ( )Tj EMC [(\024)-11.8(\002)3(\030)-11.4(\026)-6.3(\002)-9.9(\024)-10.9(\021)-17.7(\022)-19.1(\026 \n)1.3(\026)-11.8(\021)-9.9(\036)-1.7(\030)-7.6(\017)-0.6(\026)-33.1(\035\026)3.7(:)]TJ /T1_2 1 Tf -0.008 Tc 0.4 Tw [( \201)11.9(\005)-6.5(\030)-11.7(\205)15.8(\023\204)13.4(\026)-13.2(\023)1.6(\025)-4.2(\031)-1.4(\027)-5.8(\026)]TJ /Span<>> BDC 19.884 0 Td ( )Tj EMC [(\230)31.1(.)-7.3(\214)74.6(.,)-8( )]TJ 0 Tc 0 Tw -19.884 -1.218 Td [(\206)16.6(\n)2.4(\003)8.8(\002)10.8(\013)9.8(\n)9.6(\027)]TJ /Span<>> BDC ( )Tj EMC [(\036)22.8(.)7.3(\201)-2.3(.)7.8(, \240)11.8(\024)14.1(\027)1.1(\032)3(\026)-5.2(\023)9(\026)6.7(\001)14.1(\027)5.5(\025)-2.3(\023)9.6(\025)]TJ /Span<>> BDC ( )Tj EMC [(\200)1.5(.)7.3(\201)-2.3(.)7.8(, \223)8.8(\202)6.6(\026)4.4(\017)]TJ /Span<>> BDC ( )Tj EMC [(\255)27.7(.)20.1(\240)19.4(.)]TJ /T1_1 1 Tf 0.002 Tc -0.002 Tw T* [(\203)7.2(\026\023)4.2(\017\f)-10.8(\026)1.7(\027)3.7(\017)-6.7(\036)2.1( \021)-7.9(\036)-3.4(\022\f)-34(\021)-19.5(\026)5.7(:)]TJ /T1_2 1 Tf -0.01 Tc 0.01 Tw 7.694 0 Td [( \201)9.9(\005)-8.5(\030)-13.7(\205)13.8(\023)-1.6(\204)11.4(\026)-15.2(\023\025)-6.2(\031)-3.4(\027)-7.8(\026)]TJ /Span<>> BDC 6.088 0 Td ( )Tj EMC [(\230)29.1(.)-9.3(\214)72.7(.)-2.2(,)-10( \207)17.6(\205)-0.7(\001)-2.8(\013\n\027)]TJ /Span<>> BDC 4.994 0 Td ( )Tj EMC [(\255)17.6(.)19.3(\215)18.9(.)]TJ /T1_1 1 Tf 0 Tc 0.176 Tw -18.776 -1.218 Td [(\217)5.5(\036)-19(\007)-20.1(\026\022)-32.6(\021)-17.7(\017)1.4(\030)-11.8(\024)-4.2(\r)-9(\026\027)1.8(\017)-8.7(\036 \021)-9.9(\036)-5.4(\022)-1.7(\f)-36(\021)-21.5(\026)3.7(:)]TJ /T1_2 1 Tf [( \207)27.6(\205)9.3(\001)7.2(\013)9.8(\n)9.6(\027)]TJ /Span<>> BDC ( )Tj EMC [(\255)27.6(.)29.4(\215)28.8(.)7.8(, \035)14.6(\025)7.7(\013)-17.8(\205)2.1(\024)4(\n)9.7(\027)]TJ /Span<>> BDC ( )Tj EMC [(\201)-2.3(.)7.3(\201)-2.3(.)7.8(, )]TJ -0.024 Tc 0.024 Tw T* [(\216)-15.2(\031)-25.4(\t)-14.2(\031)-44.6(\023)-20.7(\n)-14.4(\027)]TJ /Span<>> BDC 3.241 0 Td ( )Tj EMC [(\216.)4.5(\216.)]TJ /T1_4 1 Tf 0 Tc 0.023 Tw -3.241 -2.436 Td (AUTHORS CONTRIBUTION)Tj /T1_1 1 Tf 1.517 Tw T* [(C)-6.5(o)0.8(nce)-0.7(p)-12.3(t a)2.4(n)-4.6(d d)-5.5(e)-13.3(s)-16.6(i)3.2(g)1.2(n)15.4(:)]TJ /T1_2 1 Tf [( O)-7.4(l)4.8(e)-3.5(g)]TJ /Span<>> BDC ( )Tj EMC [(I)2.4(.)]TJ /Span<>> BDC ( )Tj EMC [(S)15.8(us)9.6(h)7.5(k)12.9(o)-0.6(v)33.6(, )]TJ -0.002 Tc 0.002 Tw T* [(S)14.3(ta)-2.8(n)4.2(i)9(s)7.3(l)1.4(a)-6.4(v)]TJ /Span<>> BDC 3.506 0 Td ( )Tj EMC [(V)51.1(.)]TJ /Span<>> BDC 0.955 0 Td ( )Tj EMC [(C)1.2(he)-3.7(r)-16.6(n)4.2(y)-2.9(s)7.6(ho)-2.6(v)]TJ /T1_1 1 Tf 0 Tc 1.665 Tw -4.461 -1.218 Td [(C)-6.5(o)-5.8(l)-19(l)-14.3(e)-9.4(c)-32.5(t)-37.3(i)3.2(o)0.8(n a)2.4(n)-4.6(d p)-3.8(r)-6(o)-6.9(ce)-13.2(s)-12.8(s)-16.6(i)7.1(n)-1.9(g o)-2.2(f m)1.8(a)-8.4(t)-15.2(e)-2.1(r)-48(i)5.1(a)-1.5(l)-22.5(:)]TJ /T1_2 1 Tf 0 Tw ( )Tj 0.749 Tw T* [(E)19.6(l)-5.9(m)5.8(i)9.4(r)7.7(a)]TJ /Span<>> BDC ( )Tj EMC [(U)25.5(.)]TJ /Span<>> BDC ( )Tj EMC [(A)6(b)-5.9(d)5.2(u)2.8(l)-30(z)8.1(h)4.8(al)4.3(i)3(e)-4(v)10.9(a)-14(, E)20.6(v)8.2(g)-2.4(e)-2.6(n)6.2(y)]TJ /Span<>> BDC ( )Tj EMC [(A)-12.6(.)]TJ /Span<>> BDC ( )Tj EMC [(K)0.7(h)1.9(o)0.5(m)4.8(y)3.8(a)1.7(k)12.9(o)-0.6(v)33.6(, )]TJ 0 Tw T* [(D)-2(m)5.8(i)0.9(t)-5.4(r)-40.2(y)]TJ /Span<>> BDC ( )Tj EMC [(A)-12.5(.)]TJ /Span<>> BDC ( )Tj EMC [(M)6.1(t)-28.5(v)-7.8(r)7.7(al)3.3(a)-2.9(s)9.6(h)2(v)-28.6(i)7.4(l)4.3(i)-3.1(, O)-7.4(l)4.8(e)-3.4(g)]TJ /Span<>> BDC ( )Tj EMC [(M)5.4(.)]TJ /Span<>> BDC ( )Tj EMC [(Y)33.7(u)2.1(ga)-2(i)]TJ /T1_1 1 Tf -0.052 Tc 0.052 Tw T* [(Te)-75.9(x)-88(t)-52( w)-73(r)-99.9(i)-58(t)-89.4(i)-44.9(n)-53.9(g)-43(:)]TJ /T1_2 1 Tf 0 Tc 0 Tw 5.233 0 Td [( E)19.6(l)-5.9(m)5.8(i)9.4(r)7.8(a)]TJ /Span<>> BDC ( )Tj EMC [(U)25.4(.)]TJ /Span<>> BDC ( )Tj EMC [(A)6(b)-5.9(d)5.3(u)2.8(l)-30(z)8.1(h)4.8(al)4.3(i)3(e)-4(v)10.8(a)-14(, O)-7.3(l)4.8(e)-3.5(g)]TJ /Span<>> BDC ( )Tj EMC [(I)2.4(.)]TJ /Span<>> BDC ( )Tj EMC [(S)15.8(us)9.6(h)7.5(k)13(o)-0.6(v)]TJ /T1_1 1 Tf 0.006 Tc 0.514 Tw -5.233 -1.218 Td [(T)58.3(e)-17.9(x)-30(t)6( e)-5.3(dit)-31.4(i)13.1(n)4.1(g)15(:)]TJ /T1_2 1 Tf 0 Tc 0.52 Tw 5.723 0 Td [( O)-7.4(l)4.8(e)-3.5(g)]TJ /Span<>> BDC ( )Tj EMC [(I)2.4(.)]TJ /Span<>> BDC ( )Tj EMC [(S)15.8(us)9.6(h)7.5(k)12.9(o)-0.6(v)33.6(, A)3.6(l)4.8(e)-28.5(x)2.1(e)-2(i)]TJ /Span<>> BDC ( )Tj EMC [(A)-12.6(.)]TJ /Span<>> BDC ( )Tj EMC [(L)3.1(i)7.9(k)12.5(ut)1.4(o)-0.6(v)33.6(, )]TJ -0.003 Tc 0.003 Tw -5.723 -1.218 Td [(V)-8.5(ic)-31.6(t)-1.6(o)-1.7(r)]TJ /Span<>> BDC 2.285 0 Td ( )Tj EMC [(V)50.1(.)]TJ /Span<>> BDC 0.955 0 Td ( )Tj EMC [(V)20(e)-21(s)1.9(e)-4.9(lo)-3.6(v)]TJ /T1_4 1 Tf 0 Tc 0.023 Tw -3.24 -2.436 Td (\255\026\036\031\036\025\034\224 \017\225 \032\026\020\017\022\032\221 \(\ ORCID\))Tj /T1_1 1 Tf 0 Tw T* (\221\031\001\022\024\r \210.\222.)Tj /Span<>> BDC ( )Tj EMC (\227 0000-0001-9780-7916)Tj T* (\200\036\f\036\035\024\r \200.\200.)Tj /Span<>> BDC ( )Tj EMC (\227 0000-0001-9992-119X)Tj T* (\202\002\007\031\035\032\026\035\017\036\r\026 \224.\211.)Tj /Span<>> BDC ( )Tj EMC (\227 0000-0002-7750-603X)Tj T* (\223\036\030\027\t\001\024\r \221.\200.)Tj /Span<>> BDC ( )Tj EMC (\227 0000-0002-6212-9454)Tj T* (\216\024\n\016\022\024\r \213.\202.)Tj /Span<>> BDC ( )Tj EMC (\227 0000-0002-3399-0608)Tj T* (\214\017\022\031\021\024\r \202.\202.)Tj /Span<>> BDC ( )Tj EMC (\227 0000-0001-5848-4050)Tj T* (\204\021\r\030\026\035\026\001\r\017\035\017 \212.\202.)Tj /Span<>> BDC ( )Tj EMC (\227 0000-0003-3258-7881)Tj T* (\236\020\026\005 \210.\204.)Tj /Span<>> BDC ( )Tj EMC (\227 0000-0003-4679-5497)Tj /T1_4 1 Tf 0.023 Tw 0 -2.436 TD (INFORMATION ABOUT THE AUTHORS \(ORCID\))Tj /T1_1 1 Tf 0 Tw 0 -1.218 TD (Oleg I. Sushkov)Tj /Span<>> BDC ( )Tj EMC (\227 0000-0001-9780-7916)Tj T* [(V)-15(ic)-16(t)17(or V. V)30.1(esel)30(ov)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0001-9992-119X)Tj T* [(Elmir)-32.9(a U. A)-14(bdul)-39.9(zhal)-31(iev)-15(a)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0002-7750-603X)Tj T* [(S)15(t)15(anisl)-16(av V. Cher)-14.9(ny)-12.9(shov)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0002-6212-9454)Tj T* [(Ev)-21(geny A. Khomy)22.1(akov)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0002-3399-0608)Tj T* [(Ale)-18(x)12(ei A. L)-31.9(ikut)17.1(ov)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0001-5848-4050)Tj T* [(Dmi)-24(tr)-23.9(y A. Mt)-23.9(vr)-33(al)-16(ashv)-16(il)-30.9(i)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0003-3258-7881)Tj T* [(Oleg M. Y)35.1(ugai)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0003-4679-5497)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 42.5896 115.9299 Tm [(\r\031\024\034\033)48(\026)45(\024)-10(\223\033)48(\026)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0 Tc -0.116 Tw 8 0 0 8 42.5197 103.0952 Tm (1.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (\200\026\020\026\027\024\r)Tj /Span<>> BDC ( )Tj EMC (\236.\213., \216\024\n\016\022\024\r)Tj /Span<>> BDC ( )Tj EMC (\213.\202., \221\036\030\036\002\030\017\005)Tj /Span<>> BDC ( )Tj EMC (\202.\207., \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. \204\031\022\024\220\022\021\024\n\017\016 )Tj 0.01 Tc 0.355 Tw -1.296 -1.25 Td (\017)Tj /Span<>> BDC 0.527 0 Td ( )Tj EMC [(\021)0.5(\030)0.5(\026)0.6(\007)0.5(\017)0.5(\006)0.5(\017)0.5(\024)0.6(\027)0.5(\027)0.5(\026)0.5(\016)0.6( \023)0.5(\024)0.5(\035)0.5(\017)0.5(\023)0.6(\220)0.5(\022)0.5(\021)0.5(\024)0.6(\n)0.5(\017)0.5(\016)0.5( \r)]TJ /Span<>> BDC 14.186 0 Td ( )Tj EMC [(\035)0.5(\036)0.5(\004)0.6(\036)0.5(\027)0.5(\017)0.5(\017)0.6( \026)0.6(\007)0.5(\036)0.5(\027)0.5(\024)0.5(\n)0.6( \024)0.5(\002)0.5(\024)0.5(\007)0.5(\024)0.5(\004)0.6(\027)0.5(\024)0.5(\005)10( )]TJ 0 Tc 0 Tw -14.713 -1.25 Td (\022\017\001\022\017. )Tj /T1_2 1 Tf 3.197 0 Td (\222\n\023\n\033\032\n\013\024\n\023\n\202\025\002.)Tj /T1_1 1 Tf 0.04 Tw [( 2021;20\(2\):29\22634. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.33878/2073-)Tj 25.858 2.5 Td (7556-2021-20-2-29-34)Tj 0 0 0 1 k /GS1 gs 0.248 Tw 0 -1.25 TD (2.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (\200\026\020\026\027\024\r)Tj /Span<>> BDC ( )Tj EMC (\236.\213., \200\036\f\036\035\024\r)Tj /Span<>> BDC ( )Tj EMC (\200.\200., \214\017\022\031\021\024\r)Tj /Span<>> BDC ( )Tj EMC (\202.\202., \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. \205\026\022\021\024\030\t )Tj 0.337 Tw -1.296 -1.25 Td (\030\017\f\022\026 \030\036\006\017\007\017\r\026 \026\007\036\027\024\n\ \024\002\024\007\024\004\027\024\005 \022\017\001\022\017 \023\024\f\035\ \036 \017\b \031\007\026\035\036\027\017\016 )Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 0 Tw 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\033\030\031\030\213\b)-20.9(\035\231\213\233\t \021\032)50(\b)42(\032\231\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj /T1_5 1 Tf 25 0 0 25 512.8394 56.0378 Tm (29)Tj ET endstream endobj 2444 0 obj <>/Border[0 0 0]/H/N/Rect[210.894 90.3913 263.622 80.9352]/Subtype/Link/Type/Annot>> endobj 2445 0 obj <>/Border[0 0 0]/H/N/Rect[274.961 110.391 349.04 101.095]/Subtype/Link/Type/Annot>> endobj 2447 0 obj <> endobj 2446 0 obj <> endobj 2359 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.637 Tw 10 0 0 10 70.8661 724.8299 Tm (\030\036\031\035\034\021\026\021\024\r \023\026\021\024\n\024\030\235\024\ \035\024\020\017\004\036\f\022\024\020\024 \017\f\f\035\036\007\024\r\026\ \027\017\016 )Tj -0.011 Tw 0 -1.218 TD (\024\023\036\030\026\006\017\024\027\027\t\b \023\030\036\023\026\030\026\ \021\024\r \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\026\b \f)Tj /Span<>> BDC ( )Tj EMC (\017\b \017\f\022\035\033\004\036\027\017)Tj 0 Tw (-)Tj 0.081 Tw T* [(\036\n \f\024\020\035\026\f\027\024 \253per p)25(r)-32(o)17(t)17(o)-15.9(col\273. \221\021\026\021\017\f\021\017\004\036\f\022\017 \027\026\004\017\ \n\t\b )]TJ -0.04 Tw T* (\030\026\035\017\004\017\005 \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\026\b \023\024)Tj /Span<>> BDC ( )Tj EMC (\023\024\022\026\026\021\036\035\016\n R0, R1 \017)Tj /Span<>> BDC ( )Tj EMC (R\b \020\030\026\027\017\006 )Tj 0 Tw T* (\030\036\036\022\006\017\017 \r\t\016\r\035\036\027\024 \027\036 \002\t\ \035\024 \(\230\026\002\035.)Tj /Span<>> BDC ( )Tj EMC (8\).)Tj 0.301 Tw T* (\215\030\017 \026\027\026\035\017\036 \024\021\007\026\035\036\027\027\t\ \b \030\036\031\035\034\021\026\021\024\r \023\024\f\035\036 \220\027\007\ \024)Tj 0 Tw (-)Tj 0.204 Tw 0 -1.218 TD (\f\022\024\023\017\004\036\f\022\024\020\024 \031\007\026\035\036\027\017\ \016 \027\024\r\024\024\002\030\026\024\r\026\027\017\005 \n\036\021\024\ \007\026\n\017 )Tj 0.057 Tw 0 -1.218 TD (C-EMR \017)Tj /Span<>> BDC ( )Tj EMC (ESD, \n\t \017\031\004\017\035\017 \004\026\f\021\024\021\031 \035\024\022\ \026\035\034\027\t\b \030\036\006\017\007\017)Tj 0 Tw (-)Tj 0.096 Tw T* (\r\024\r \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\026\b. \202\027\026\035\017 \002\t\035 \023\030\024\ \017\r\036\007\036\027 \031)Tj /Span<>> BDC ( )Tj EMC (45)Tj /Span<>> BDC ( )Tj EMC (\(86,5%\) )Tj -0.046 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (52)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \r)Tj /Span<>> BDC ( )Tj EMC (\024\f\027\024\r\027\024\005 \017)Tj /Span<>> BDC ( )Tj EMC (\031 46)Tj /Span<>> BDC ( )Tj EMC (\(90,2%\) \017)Tj /Span<>> BDC ( )Tj EMC (51)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\034)Tj 0 Tw (-)Tj 0.172 Tw T* (\027\024\020\024)Tj /Span<>> BDC ( )Tj EMC (\227 \022\024\027\021\030\024\035\034\027\024\005 \020\030\031\023\023\t\ . Me\007\017\026\027\026 \027\026\002\035\033\007\036\027\017\016 )Tj 0.332 Tw T* (\026)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\026\n\017 \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\026\b C-EMR \017)Tj /Span<>> BDC ( )Tj EMC (ESD \f\024\f\021\026\r\017\035\026 )Tj 0.267 Tw 0 -1.218 TD (12 \(12\22615\) \017)Tj /Span<>> BDC ( )Tj EMC (12 \(12\22614\) \n\036\f\016\006\036\r, \f\024\024\021\r\036\021\f\021\r\ \036\027\027\024 )Tj 0 Tw 0 -1.218 TD (\()Tj /T1_1 1 Tf (p)Tj /T1_0 1 Tf 0.114 Tw /Span<>> BDC ( )Tj EMC 1.194 0 Td (=)Tj /Span<>> BDC ( )Tj EMC 0.846 0 Td [(0,5\). )0.5(\204\036\f\021\027\t\005 )0.5(\030\036\006\017\007\017\r )0.5(\002\t\035 )0.5(\r\t\016\r\035\036\027 )0.6(\031)]TJ /Span<>> BDC ( )Tj EMC 16.539 0 Td (2)Tj /Span<>> BDC ( )Tj EMC 0.846 0 Td (\(3,8%\) )Tj 0.257 Tw -19.426 -1.218 Td (\017)Tj /Span<>> BDC ( )Tj EMC (\031)Tj /Span<>> BDC ( )Tj EMC (1)Tj /Span<>> BDC ( )Tj EMC (\(2,0%\) \002\024\035\034\027\024\020\024 \r)Tj /Span<>> BDC ( )Tj EMC (\024\f\027\024\r\027\024\005 \017)Tj /Span<>> BDC ( )Tj EMC (\022\024\027\021\030\024\035\034\027\024\005 )Tj 0.104 Tw 0 -1.218 TD (\020\030\031\023\023\036, \f\024\024\021\r\036\021\f\021\r\036\027\027\024\ \()Tj /T1_1 1 Tf 0 Tw (p)Tj /T1_0 1 Tf 0.104 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (1,0\). \200\t\016\r\035\036\027\027\t\036 \030\036\006\017)Tj 0 Tw (-)Tj 0.111 Tw T* (\007\017\r\t \002\t\035\017 \031\007\026\035\036\027\t \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\022\024\027\021\030\024\035\034\027\024\005 \022\024\035\024\027\024\f\022\ \024\023\017\017 )Tj 0.049 Tw T* (\n\036\021\024\007\024\n \n\031\022\024\220\022\021\024\n\017\017. \215\ \026\006\017\036\027\021\026\n \002\t\035\024 \030\036\022\024\n\036\027\ \007\024)Tj 0 Tw (-)Tj 0.261 Tw T* (\r\026\027\024 \r\t\023\024\035\027\017\021\034 \022\024\027\021\030\024\ \035\034\027\031\033 \022\024\035\024\027\024\f\022\024\023\017\033 \004\ \036\030\036 )Tj 0.212 Tw T* (3\2266)Tj /Span<>> BDC ( )Tj EMC 2 0 Td [(\n\036\f\016\006\036\r. )0.6(\215\030\017)]TJ /Span<>> BDC ( )Tj EMC 6.202 0 Td [(\023\024\r\021\024\030\027\024\n )0.6(\220\027\007\024\f\022\024\023\017\004\036\f\022\024\n )0.5(\017\f)]TJ 0 Tw (-)Tj 0.01 Tw -8.202 -1.218 Td (\f\035\036\007\024\r\026\027\017\017 \030\036\006\017\007\017\r\026 \027\ \024\r\024\024\002\030\026\024\r\026\027\017\005 \r\t\016\r\035\036\027\ \024 \027\036 )Tj 0 Tw T* (\002\t\035\024.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 70.936 432.5578 Tm [(\037\036)10(\032\223\212\226\034\022\031\034)]TJ 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0 Tc 0.288 Tw 10 0 0 10 70.8661 408.2018 Tm (\221\036\020\024\007\027\016 \r)Tj /Span<>> BDC ( )Tj EMC (\026\030\f\036\027\026\035\036 \r\030\026\004\026-\220\027\007\024\f\022\ \024\023\017\f\021\026 \f\031\013\036\f\021\r\031)Tj 0 Tw (-)Tj 0.409 Tw T* (\036\021 \n\027\024\032\036\f\021\r\024 \021\036\b\027\017\022 \220\027\007\ \024\f\022\024\023\017\004\036\f\022\024\020\024 \031\007\026\035\036\027\ \017\016 )Tj 0.136 Tw T* (\024\023\031\b\024\035\036\005 \032\036\035\031\007\024\004\027\024-\022\ \017\001\036\004\027\024\020\024 \021\030\026\022\021\026. \025\026\032\007\ \026\016 \n\036)Tj 0 Tw (-)Tj 0.215 Tw T* (\021\024\007\017\022\026 \017\n\036\036\021 \022\026\022 \023\030\036\017\ \n\031\013\036\f\021\r\026, \021\026\022 \017)Tj /Span<>> BDC ( )Tj EMC (\027\036\007\024\f\021\026\021\022\017. )Tj -0.021 Tw T* (\200)Tj /Span<>> BDC ( )Tj EMC (\f\r\016\017 \f)Tj /Span<>> BDC ( )Tj EMC (\220\021\017\n, \017\n\036\027\027\024 \023\036\030\f\024\027\026\035\017\ \017\030\024\r\026\027\027\t\005 \023\024\007\b\024\007 )Tj 0.003 Tw T* (\023\030\017)Tj /Span<>> BDC ( )Tj EMC (\r\t\002\024\030\036 \021\024\020\024 \017\035\017 \017\027\024\020\024 \ \n\036\021\024\007\026 \220\027\007\024\f\022\024\023\017\004\036\f\022\024\ \020\024 )Tj 0.084 Tw T* (\031\007\026\035\036\027\017\016 \024\023\031\b\024\035\017 \017\020\030\ \026\036\021 \027\026\004\017\n\031\033 \030\024\035\034 \r)Tj /Span<>> BDC ( )Tj EMC (\007\024\f\021\017\032\036)Tj 0 Tw (-)Tj 0.189 Tw T* (\027\017\017 \027\026\017\035\031\004\001\017\b \030\036\031\035\034\021\ \026\021\024\r \035\036\004\036\027\017\016 \031)Tj /Span<>> BDC ( )Tj EMC (\022\024\027\022\030\036\021\027\024\020\024 )Tj 0 Tw T* (\023\026\006\017\036\027\021\026.)Tj 0.721 Tw T* (\204\036\021\024\007\017\022\026 \220\027\007\024\f\022\024\023\017\004\036\ \f\022\024\005 \030\036\036\022\006\017\017 \f\035\017\017\f\021\024\005\ )Tj 0.371 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\006\017\030\022\031\035\016\030\027\t\n \030\026\030\036\024\n \023\030\ \036\007\f\021\026\r\035\016\036\021 \f\024\002\024\005 \020\017)Tj 0 Tw (-)Tj 0.093 Tw T* (\002\030\017\007\027\t\005 \n\036\021\024\007, \024\002\255\036\007\017\027\ \016\033\013\017\005 \220\021\026\023\t \n\031\022\024\220\022\021\024\n\ \017\017 )Tj 0 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (ESD.)Tj 0.248 Tw T* [(\221\030\026\r\027\017\021\036\035\034\027\t\005 )0.5(\026\027\026\035\017 \030\036\031\035\034\021\026\021\024\r \007\026\027\ \027\024\020\024 \017\f\f\035\036)]TJ 0 Tw (-)Tj 0.276 Tw T* (\007\024\r\026\027\017\016 \023\030\024\007\036\n\024\027\f\021\030\017\030\ \024\r\026\035 \002\036\024\023\026\f\027\024\f\021\034 \n\036\021\024\007\ \017)Tj 0 Tw (-)Tj 0.362 Tw T* [(\022\017 )0.5(\221-EMR, )0.6(\f\024\023\024\f\021\026\r\017\n\031\033 )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC 12.376 0 Td [(\n\036\021\024\007\024\n )0.5(\220\027\007\024\f\022\024\023\017\004\036)]TJ 0 Tw (-)Tj 0.152 Tw -12.376 -1.218 Td (\f\022\024\005 \023\024\007\f\035\017\017\f\021\024\005 \007\017\f\f\036\ \022\006\017\017. \223\026\f\021\024\021\026 \024\f\035\024\032\027\036\027\ \017\005 )Tj 0.303 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC 1.01 0 Td [(\020\030\031\023\023\026\b )0.5(\f\021\026\021\017\f\021\017\004\036\f\022\017 )0.5(\027\026\004\017\n\024 )0.5(\027\036 )0.5(\030\026\035\017\004\026\035\026\f\034. )]TJ -0.062 Tw -1.01 -1.218 Td (\200\026\032\027\024, \004\021\024 \004\026\f\021\024\021\026 \022\035\017\ \027\017\004\036\f\022\017 \027\026\004\017\n\t\b \024\f\035\024\032\027\ \036\027\017\005 )Tj 0.055 Tw T* (\027\036 \r\t\f\024\022\026. \210\027\017 \r\024\027\017\022\035\017 \r\ )Tj /Span<>> BDC ( )Tj EMC (3)Tj /Span<>> BDC ( )Tj EMC (\(5,7%\) \f\035\031\004\026\016\b \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\r\t)Tj 0 Tw (-)Tj 0.043 Tw T* (\023\024\035\027\036\027\017\017 C-EMR \017)Tj /Span<>> BDC ( )Tj EMC (\031 2 \(3,9%\) \023\026\006\017\036\027\021\024\r)Tj /Span<>> BDC ( )Tj EMC (\227 \f)Tj /Span<>> BDC ( )Tj EMC (\017\f\023\024\035\034)Tj 0 Tw (-)Tj 0.07 Tw T* (\024\r\026\027\017\036\n \n\036\021\024\007\026 ESD, \004\021\024 \022\024\ \030\030\036\035\017\030\031\036\021 \f)Tj /Span<>> BDC ( )Tj EMC (\030\036\031\035\034\021\026\021\026)Tj 0 Tw (-)Tj -0.012 Tw T* (\n\017 \030\026\027\036\036 \023\030\024\r\036\007\036\027\027\t\b \017\f\ \f\035\036\007\024\r\026\027\017\005 [22,23]. \210\007\027\026\022\024 )Tj 0.035 Tw T* (\027\036\022\024\021\024\030\t\036 \026\r\021\024\030\t \f\024\024\002\013\ \026\033\021 \024)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\036\036 \r\t\f\024\022\024\005 \004\026\f\021\024)Tj 0 Tw (-)Tj 0.127 Tw T* (\021\036 \030\026\r\017\021\017\016 \024\f\035\024\032\027\036\027\017\005\ \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\031\007\026\035\036\027\017\017 \022\030\031\023\027\t\b \027\024)Tj 0 Tw (-)Tj -0.015 Tw T* (\r\024\024\002\030\026\024\r\026\027\017\005 \021\024\035\f\021\024\005\ \022\017\001\022\017 \n\036\021\024\007\024\n C-EMR, \007\024\f\021\017\ )Tj 0 Tw (-)Tj 0.085 Tw T* (\020\026\033\013\036\005 35,1%, \017)Tj /Span<>> BDC ( )Tj EMC (\022\024\021\024\030\t\b \r)Tj /Span<>> BDC ( )Tj EMC (21,6% -\220\021\024 \023\036\030\235\024\030\026\006\017\017 )Tj 0 Tw T* (\f\021\036\027\022\017 \022\017\001\022\017, \026)Tj /Span<>> BDC ( )Tj EMC (\r 13,5%)Tj /Span<>> BDC ( )Tj EMC (\227 \022\030\024\r\024\021\036\004\036\027\017\016 [24].)Tj 0.144 Tw 23.244 49.93 Td (\203\026\017\002\024\035\036\036 \f\036\030\034\036\027\t\036 \024\f\035\ \024\032\027\036\027\017\016 \r)Tj /Span<>> BDC ( )Tj EMC (\027\026\001\036\n \017\f\f\035\036\007\024)Tj 0 Tw (-)Tj 0.232 Tw T* (\r\026\027\017\017, \026)Tj /Span<>> BDC ( )Tj EMC (\017\n\036\027\027\024 \017\027\021\030\026\024\023\036\030\026\006\017\024\ \027\027\024\036 \022\030\024\r\024\021\036\004\036\027\017\036 )Tj 0.321 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\023\024\f\035\036\007\031\033\013\036\005 \022\024\027\r\036\030\f\017\036\ \005 \r\n\036\001\026\021\036\035\034\f\021\r\026 \017)Tj /Span<>> BDC ( )Tj EMC (\253\024\021)Tj 0 Tw (-)Tj 0.186 Tw T* [(\f\030\024\004\036\027\027\026\016\273 )0.6(\023\036\030\235\024\030\026\006\017\016, )0.6(\023\024\021\030\036\002\024\r\026\r\001\026\016 )0.5(\023\024\r\021\024\030\027\024\005 )]TJ 0.159 Tw T* (\024\023\036\030\026\006\017\017, \r\024\027\017\022\035\017 \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 C-EMR. \200)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\r\024\n \f\035\031)Tj 0 Tw (-)Tj 0.139 Tw T* [(\004\026\036 )0.5(\n\t )0.6(\f\r\016\t\r\026\036\n )0.5(\220\021\024 )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC 10.606 0 Td [(\027\026\035\017\004\017\036\n )0.5(\022\030\031\023\027\t\b )0.5(\f\024\f\031\007\024\r )]TJ 0.107 Tw -10.606 -1.218 Td (\r)Tj /Span<>> BDC ( )Tj EMC 0.813 0 Td [(\023\024\007\f\035\017\017\f\021\024\n )0.6(\f\035\024\036 )0.5(\f\021\036\027\022\017 )0.5(\022\017\001\022\017 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 15.255 0 Td [(\031\f\017\035\036\027\027\024\005 )0.6(\023\036)]TJ 0 Tw (-)Tj 0.208 Tw -16.069 -1.218 Td (\030\017\f\021\026\035\034\021\017\022\024\005, \022\024\021\024\030\026\ \016 \f\031\013\036\f\021\r\036\027\027\024 \026\021\030\031\007\027\017\ \035\026 \220\027)Tj 0 Tw (-)Tj 0.189 Tw T* (\007\024\f\022\024\023\017\004\036\f\022\024\036 \031\007\026\035\036\027\ \017\036 \024\023\031\b\024\035\017 \007\017\f\021\026\035\034\027\024\005\ \021\030\036\021\017 )Tj -0.008 Tw T* (\f\017\020\n\024\r\017\007\027\024\005 \022\017\001\022\017. \215\036\030\ \235\024\030\026\006\017\016 \r)Tj /Span<>> BDC ( )Tj EMC (\023\024\f\035\036\024\023\036\030\026\006\017\024\027)Tj 0 Tw (-)Tj -0.036 Tw T* (\027\024\n \023\036\030\017\024\007\036 \r\024 \r\021\024\030\024\n \027\ \026\002\035\033\007\036\027\017\017, \r\036\030\024\016\021\027\036\036\ \r\f\036\020\024, )Tj 0.157 Tw T* (\f\r\016\026\027\026 \f)Tj /Span<>> BDC ( )Tj EMC (\030\026\f\023\024\035\024\032\036\027\017\036\n \024\023\031\b\024\035\017\ \r)Tj /Span<>> BDC ( )Tj EMC (\f\035\036\023\024\005 \022\017\001\022\036, )Tj 0 Tw T* (\020\007\036 \022\017\001\036\004\027\026\016 \f\021\036\027\022\026 \027\ \026\017\002\024\035\036\036 \021\024\027\022\026\016.)Tj 0.033 Tw T* (\215\024\f\022\024\035\034\022\031 \r)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\006\036\f\f\036 \017\f\f\035\036\007\024\r\026\027\017\016 \ \r)Tj /Span<>> BDC ( )Tj EMC (\024\002\036\017\b \020\030\031\023\023\026\b )Tj 0.068 Tw T* [(\002\t\035\017 )0.5(\022\024\027\r\036\030\f\017\017, )0.6(\n\t )0.5(\r\t\023\024\035\027\017\035\017 )0.5(\030\036\020\030\036\f\f\017\024\027\027\t\005 )0.6(\026\027\026)]TJ 0 Tw (-)Tj 0.131 Tw T* [(\035\017, )0.5(\022\024\021\024\030\t\005 )0.6(\023\024\n\024\020 )0.5(\024\023\030\036\007\036\035\017\021\034 )0.6(\235\026\022\021\024\030\t, )0.5(\023\024\r\t\001\026\033)]TJ 0 Tw (-)Tj 0.247 Tw T* (\013\017\036 \r\036\030\024\016\021\027\024\f\021\034 \021\026\022\024\020\ \024 \017\f\b\024\007\026: \027\036\031\007\024\002\027\024\036 \030\026\ \f\023\024)Tj 0 Tw (-)Tj 0.099 Tw T* (\035\024\032\036\027\017\036 \024\023\031\b\024\035\017 \(\210\234)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (18,3\) \017)Tj /Span<>> BDC ( )Tj EMC (\017\027\021\030\026\024\023\036\030\026\006\017\024\027\027\024\036 )Tj 0.069 Tw T* (\024\f\035\024\032\027\036\027\017\036 \(\210\234)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (37,5\). \203\026\001 \024\023\t\021 \f\r\017\007\036\021\036\035\034\f\021\ \r\031\036\021, )Tj 0.064 Tw T* (\004\021\024 \021\013\026\021\036\035\034\027\t\005 \024\021\002\024\030\ \023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\031\004\036\021\024\n \023\030\036\007\f\021\026\r)Tj 0 Tw (-)Tj 0.29 Tw T* (\035\036\027\027\t\b \r\t\001\036 \235\026\022\021\024\030\024\r, \022\030\ \026\005\027\036 \r\026\032\036\027 \017)Tj /Span<>> BDC ( )Tj EMC (\023\024\n\024\032\036\021 )Tj 0.123 Tw T* (\r\030\026\004\031-\220\027\007\024\f\022\024\023\017\f\021\031 \r\t\007\ \036\035\017\021\034 \022\026\021\036\020\024\030\017\033 \023\026\006\017\ \036\027\021\024\r, )Tj 0.308 Tw T* (\031)Tj /Span<>> BDC ( )Tj EMC (\022\024\021\024\030\t\b \f\035\036\007\031\036\021 \024\021\022\026\026\ \021\034\f\016 \024\021 \r\t\023\024\035\027\036\027\017\016 ESD )Tj 0.029 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\023\024\035\034\031 C-EMR \017)Tj /Span<>> BDC ( )Tj EMC (\027\026\024\002\024\030\024\021, \023\024\f\022\024\035\034\022\031 \007\ \026\027\027\t\036 \021\036\b\027\017)Tj 0 Tw (-)Tj 0.158 Tw T* (\022\017 \220\027\007\024\f\022\024\023\017\004\036\f\022\024\020\024 \031\ \007\026\035\036\027\017\016 \024\002\036\f\023\036\004\017\r\026\033\021\ \f\024\023\024)Tj 0 Tw (-)Tj 0.091 Tw T* (\f\021\026\r\017\n\024 \r\t\f\024\022\031\033 \004\026\f\021\024\021\031\ )Tj /T1_1 1 Tf (en bloc)Tj /T1_0 1 Tf ( \030\036\036\022\006\017\017 \017, \r)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\n )Tj 0.292 Tw T* (\023\035\026\027\036, \016\r\035\016\033\021\f\016 \030\026\r\027\024\027\ \026\004\027\t\n\017. \222\f\b\024\007\016 \017)Tj /Span<>> BDC ( )Tj EMC (\023\024\035\031)Tj 0 Tw (-)Tj 0.236 Tw T* (\004\036\027\027\t\b \030\036\031\035\034\021\026\021\024\r, \023\030\017\ )Tj /Span<>> BDC ( )Tj EMC (\027\036\031\007\024\002\027\024\n \030\026\f\023\024\035\024\032\036\027\ \017\017 )Tj 0.148 Tw T* (\024\023\031\b\024\035\017 \007\035\016 \r\t\023\024\035\027\036\027\017\ \016 ESD, \026)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\032\036 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\027\026\035\017\004\017\017 )Tj 0.567 Tw T* (\235\017\002\030\024\026 \023\024\007\f\035\017\017\f\021\024\020\024 \ \f\035\024\016, \027\036\024\002\b\024\007\017\n\024 \024\021\007\026)Tj 0 Tw (-)Tj 0.084 Tw T* (\r\026\021\034 \023\030\036\007\023\024\004\021\036\027\017\036 \n\036\021\ \024\007\031 C-EMR. \202)Tj /Span<>> BDC ( )Tj EMC [(\r \f\035\031\004\026\016\b, )0.5(\022\024\020\007\026 )]TJ 0.185 Tw T* [(\024\023\031\b\024\035\034 )0.6(\035\024\022\026\035\017\031\036\021\f\016 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 10.551 0 Td [(\023\030\026\r\t\b )0.5(\024\021\007\036\035\026\b )0.6(\024\002\024\007\024\004\027\024\005 )]TJ 0.199 Tw -10.551 -1.218 Td (\022\017\001\022\017, \020\007\036 \021\024\027\034\001\036 \022\017\001\ \036\004\027\026\016 \f\021\036\027\022\026 \017\035\017 \r)Tj /Span<>> BDC ( )Tj EMC (\024\f\027\024\r\026)Tj 0 Tw (-)Tj 0.009 Tw T* [(\027\017\017 \027\024\r\024\024\002\030\026\024\r\026\027\017\016 )0.5(\024\023\030\036\007\036\035\016\033\021\f\016 \022\030\031\023\027\t\036\ )0.5(\f\024\f\031\007\t )]TJ 0.158 Tw T* [(\023\024\007\f\035\017\017\f\021\024\020\024 \f\035\024\016, \f\035\036\ \007\031\036\021 )0.5(\017\f\023\024\035\034\024\r\026\021\034 \220\027\007\024\f\022\024)]TJ 0 Tw (-)Tj T* (\023\017\004\036\f\022\031\033 \023\024\007\f\035\017\017\f\021\031\033\ \007\017\f\f\036\022\006\017\033.)Tj 0.056 Tw T* (\211\007\026\035\036\027\017\036 \024\023\031\b\024\035\017 \036\007\017\ \027\t\n \002\035\024\022\024\n \007\026\036\021 \r\024\n\024\032\027\024\ \f\021\034 )Tj -0.064 Tw T* (\022\024\030\030\036\022\021\027\024\005 \020\017\f\021\024\035\024\020\017\ \004\036\f\022\024\005 \024\006\036\027\022\017 \023\030\036\023\026\030\ \026\021\026 \017)Tj /Span<>> BDC ( )Tj EMC (\f\027\017)Tj 0 Tw (-)Tj 0.067 Tw T* (\032\026\036\021 \030\017\f\022 \030\026\r\017\021\017\016 \030\036\006\ \017\007\017\r\026. \230\026\022, \f\024\020\035\026\f\027\024 \007\026\027\ \027\t\n )Tj 0.175 Tw T* [(\022\030\031\023\027\024\020\024 \n\036\021\026\026\027\026\035\017\026\ Belder)-24(bos T.D. \017)]TJ /Span<>> BDC ( )Tj EMC (\f\024\026\r\021., \024\002\255)Tj 0 Tw (-)Tj 0.216 Tw T* (\036\007\017\027\017\r\001\036\020\024 \030\036\031\035\034\021\026\021\ \t 33 \017\f\f\035\036\007\024\r\026\027\017\005, \020\007\036 \r\f\036\n\ )Tj 0.429 Tw T* [(\023\026\006\017\036\027\021\026\n )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC 6.142 0 Td [(\220\023\017\021\036\035\017\026\035\034\027\t\n\017 )0.6(\027\024\r\024\024\002\030\026\024\r\026\027\017\016\n\017 )]TJ 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0.171 Tw 9 0 0 9 303.3071 730.483 Tm (\020\004\206\f\t\204\004 8.)Tj 0 0 0 1 k /GS1 gs /T1_1 1 Tf ( \212\031\016\205\023\022\024\026\024\020 \033\026\024\n\003\n\032\f\n\023\ \n\202\025\006\031\t\013\n\202\n \025\t\t\023\031\030\n)Tj 0 Tw (-)Tj 0.13 Tw 0 -1.2 TD (\027\026\021\025\002 \n\033\031\032\026\203\025\n\021\021\020\004 \033\032\ \031\033\026\032\026\024\n\027 \027)Tj /Span<>> BDC ( )Tj EMC (\202\032\205\033\033\026\004 \t\n\202\023\026\t\021\n \026\021\026)Tj 0 Tw (-)Tj T* (\023\025\016\205 \253per protocol\273)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0.038 Tw T* [(T)48(able 8.)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf [( R)21(esults of the pathomor)-17.9(phology of specimens accord)]TJ 0 Tw (-)Tj T* [(ing to the \236per p)46.1(ro)13(tocol\237 analysis)]TJ ET 0 0 0 1 K 0.5 w /GS2 gs q 1 0 0 1 303.3071 682.781 cm 0 0 m 77.673 0 l S Q q 1 0 0 1 303.5571 661.9618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 380.9802 682.781 cm 0 0 m 53.692 0 l S Q q 1 0 0 1 380.9802 661.9618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 434.6724 682.781 cm 0 0 m 53.692 0 l S Q q 1 0 0 1 434.6724 661.9618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 488.3646 682.781 cm 0 0 m 36.045 0 l S Q q 1 0 0 1 488.3646 661.9618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 524.1594 661.9618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 303.3071 661.7118 cm 0 0 m 77.673 0 l S Q q 1 0 0 1 303.5571 650.5005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 380.9802 661.7118 cm 0 0 m 53.692 0 l S Q q 1 0 0 1 434.6724 661.7118 cm 0 0 m 53.692 0 l S Q q 1 0 0 1 488.3646 661.7118 cm 0 0 m 36.045 0 l S Q q 1 0 0 1 524.1594 650.5005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 303.3071 650.2505 cm 0 0 m 77.673 0 l S Q q 1 0 0 1 303.5571 639.0392 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 380.9802 650.2505 cm 0 0 m 53.692 0 l S Q q 1 0 0 1 380.9802 639.0392 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 434.6724 650.2505 cm 0 0 m 53.692 0 l S Q q 1 0 0 1 434.6724 639.0392 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 488.3646 650.2505 cm 0 0 m 36.045 0 l S Q q 1 0 0 1 488.3646 639.0392 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.1594 639.0392 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 303.3071 638.7892 cm 0 0 m 77.673 0 l S Q q 1 0 0 1 303.5571 627.5779 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 380.9802 638.7892 cm 0 0 m 53.692 0 l S Q q 1 0 0 1 380.9802 627.5779 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 434.6724 638.7892 cm 0 0 m 53.692 0 l S Q q 1 0 0 1 434.6724 627.5779 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 488.3646 638.7892 cm 0 0 m 36.045 0 l S Q q 1 0 0 1 488.3646 627.5779 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.1594 627.5779 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 303.3071 627.3279 cm 0 0 m 77.673 0 l S Q q 1 0 0 1 303.5571 616.1166 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 380.9802 627.3279 cm 0 0 m 53.692 0 l S Q q 1 0 0 1 380.9802 616.1166 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 434.6724 627.3279 cm 0 0 m 53.692 0 l S Q q 1 0 0 1 434.6724 616.1166 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 488.3646 627.3279 cm 0 0 m 36.045 0 l S Q q 1 0 0 1 488.3646 616.1166 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.1594 616.1166 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 303.3071 615.8666 cm 0 0 m 77.673 0 l S Q q 1 0 0 1 380.9802 615.8666 cm 0 0 m 53.692 0 l S Q q 1 0 0 1 434.6724 615.8666 cm 0 0 m 53.692 0 l S Q q 1 0 0 1 488.3646 615.8666 cm 0 0 m 36.045 0 l S Q BT /GS1 gs /T1_3 1 Tf 8 0 0 8 325.5289 669.3464 Tm (\200\004\006\004\214\r\003\006)Tj 8.971 0.6 Td (C-EMR)Tj -0.453 -1.2 Td (\()Tj /T1_4 1 Tf (n)Tj /T1_3 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (49\))Tj 7.69 1.2 Td (ESD)Tj -0.979 -1.2 Td (\()Tj /T1_4 1 Tf (n)Tj /T1_3 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (45\))Tj /T1_4 1 Tf 7.103 0.6 Td (p)Tj /T1_0 1 Tf -24.724 -2.033 Td (\206\030\026\027\017\006\t \030\036\036\022\006\017\017, )Tj /T1_1 1 Tf (n)Tj /T1_0 1 Tf ( \(%\))Tj 0 -1.433 TD (R0)Tj 10.471 0 Td (43)Tj /Span<>> BDC ( )Tj EMC (\(87,7%\))Tj 7.091 0 Td (44)Tj /Span<>> BDC ( )Tj EMC (\(97,8\))Tj 6.579 0 Td (0,1*)Tj -24.141 -1.433 Td (R1)Tj 10.971 0 Td (2)Tj /Span<>> BDC ( )Tj EMC (\(4,1%\))Tj 8.17 0 Td (0)Tj 5 0 Td (0,5*)Tj -24.141 -1.433 Td (R\b)Tj 10.971 0 Td (4)Tj /Span<>> BDC ( )Tj EMC (\(8,2%\))Tj 6.712 0 Td (1)Tj /Span<>> BDC ( )Tj EMC (\(2,2%\))Tj 6.459 0 Td (0,4*)Tj /T1_1 1 Tf 7 0 0 7 303.3071 604.382 Tm (\032\025\003\031\006\026\021\025\031: \032*)Tj /Span<>> BDC ( )Tj EMC (\227 \024\n\006\021\020\017 \013\032\025\024\031\032\025\017 \225\025\001\ \031\032\026)Tj 1 0.68 0 0.12 k /GS0 gs /T1_5 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\033\030\031\030\213\b)-20.9(\035\231\213\233\t \021\032)50(\b)42(\032\231\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj -51.938 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 23, \023\0221)69(, 202)69(4)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 23, \023\0221)69(, 202)69(4)]TJ /T1_6 1 Tf 25 0 0 25 28.1276 56.0378 Tm (28)Tj ET endstream endobj 2358 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\235\001\201\025\006\n)10(\025\221\220\017\016\006\n\013\205 \024\215\n)10(\025)21(\222)21(\232\n)-9.9(\026)11(\025\024\220\205 \006\022\227\220\002\n\215\007\205\002\001\020\024 \002\ \013\222\002\016\222\025\024 )]TJ 0 -1 TD [(\006)-10(\007\220\222\220\006)-9.9(\026)11(\025\203 \025\f\025\007\025\017\n\220 \r\022\007\016\017\016\001\220\220\ \025\221\215)21.1(\207\025\007\016\203 \025\f\025\201\025\017\001\025\203 \n\220\n\220. )]TJ T* [(\033\016\222)21(\215\007\216)21(\026)11(\013\026\020 \002\013\001\201\025\024\220\222\220\002\025\r\013\001\001\025\ \202)10(\025 \220\006\006)-10(\007\016\201\025\r\013\001\220\205.)]TJ 34.507 2 Td [(Endoscopic mucosal r)31(esection with a cir)31(cumfer)31.1(ential incision in th)11(e )]TJ 2.851 -1 Td [(r)31(emov)10(al of colon neoplasms. Results of a r)21(andomiz)10.1(ed trial.)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0.138 Tw 10 0 0 10 42.5197 310.7779 Tm (\023\036\030\017\f\021\026\035\034\021\017\022\026 \022\017\001\022\017 \ \(\210\234)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (15,8; 95% \212\222:3,1\22683,1; )Tj /T1_2 1 Tf 0 Tw 0 -1.218 TD (\032)Tj /T1_1 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,001\) \(\230\026\002\035.)Tj /Span<>> BDC ( )Tj EMC (6\).)Tj 0.605 Tw T* (\212\026\035\036\036 \027\026\n\017 \002\t\035\026 \030\026\030\026\002\ \024\021\026\027\026 \023\030\024\020\027\024\f\021\017\004\036\f\022\026\ \016 )Tj 0.645 Tw T* [(\n\024\007\036\035\034 \026\r\017\f\017\n\024\f\021\017 )0.5(\r\036\030\024\016\021\027\024\f\021\017 \022\024\027\r\036\030\f\017\017\ )0.5(\024\021 )]TJ 0.446 Tw T* [(\235\026\022\021\024\030\024\r, )0.5(\f\021\026\021\017\f\021\017\004\036\f\022\017 )0.6(\027\026\004\017\n\024 )0.6(\031\r\036\035\017\004\017\r\026\033\013\017\b )]TJ 0.682 Tw T* (\r\036\030\024\016\021\027\024\f\021\034 \030\026\r\017\021\017\016 \022\ \024\027\r\036\030\f\017\017 \r\n\036\001\026\021\036\035\034\f\021\r\026\ )Tj 0.246 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\017\f\023\024\035\034\024\r\026\027\017\036\n \n\036\021\024\007\026 \002\ \017\027\026\030\027\024\005 \035\024\020\017\f\021\017\004\036\f\022\024\ \005 )Tj 0 Tw T* (\030\036\020\030\036\f\f\017\017 \f)Tj /Span<>> BDC ( )Tj EMC (\024\021\002\024\030\024\n \235\026\022\021\024\030\024\r \n\036\021\024\ \007\024\n \017\f\022\035\033\004\036\027\017\016.)Tj 0.075 Tw T* (\200 \030\036\031\035\034\021\026\021\036 \023\030\024\r\036\007\036\027\ \027\024\020\024 \n\027\024\020\024\235\026\022\021\024\030\027\024\020\024\ \026\027\026\035\017)Tj 0 Tw (-)Tj 0.041 Tw T* (\026 \027\036\026\r\017\f\017\n\t\n\017 \235\026\022\021\024\030\026\n\ \017, \f\021\026\021\017\f\021\017\004\036\f\022\017 \027\026\004\017\n\ \024 )Tj 0.121 Tw T* (\023\024\r\t\001\026\033\013\017\n\017 \r\036\030\024\016\021\027\024\f\021\ \034 \030\026\r\017\021\017\016 \022\024\027\r\036\030\f\017\017 \220\027\ )Tj 0 Tw (-)Tj 0.33 Tw T* [(\007\024\f\022\024\023\017\004\036\f\022\024\020\024 )0.6(\r\n\036\001\026\021\036\035\034\f\021\r\026, )0.6(\024\022\026\026\035\017\f\034 )0.5(\027\036\031\007\024\002)]TJ 0 Tw (-)Tj 0.052 Tw T* (\027\024\036 \030\026\f\023\024\035\024\032\036\027\017\036 \024\023\031\ \b\024\035\017 \(\210\234)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (18,3; 95% \212\222:1,9\226)Tj 0 Tw T* (176,8; )Tj /T1_2 1 Tf 2.946 0 Td (p)Tj /T1_1 1 Tf 0.217 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC 1.877 0 Td (0,01\) \017)Tj /Span<>> BDC ( )Tj EMC 3.472 0 Td (\017\027\021\030\026\024\023\036\030\026\006\017\024\027\027\024\036 \024\ \f\035\024\032\027\036\027\017\036 )Tj 0 Tw -8.295 -1.218 Td (\(\210\234)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (37,5; 95% \212\222:1,1 1317,9; )Tj /T1_2 1 Tf (p)Tj /T1_1 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,04\).)Tj 0.527 Tw T* (\202\027\026\035\017 \030\036\031\035\034\021\026\021\024\r \023\026\021\ \024\n\024\030\235\024\035\024\020\017\004\036\f\022\017\b \017\f\f\035\036\ )Tj 0 Tw (-)Tj 0.52 Tw T* (\007\024\r\026\027\017\005 \024\023\036\030\026\006\017\024\027\027\t\b \ \023\030\036\023\026\030\026\021\024\r \023\024\022\026\026\035, \004\021\ \024 )Tj 0.159 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 ESD \027\026\002\035\033\007\026\035\024\f\034 \ \027\036\f\022\024\035\034\022\024 \002\024\035\034\001\036\036 \004\017\ \f)Tj 0 Tw (-)Tj 0.348 Tw T* (\035\024 \030\036\036\022\006\017\005 \024\023\031\b\024\035\017 \036\007\ \017\027\t\n \002\035\024\022\024\n \023\024)Tj /Span<>> BDC ( )Tj EMC (\f\030\026\r\027\036)Tj 0 Tw (-)Tj 0.239 Tw T* (\027\017\033 \f)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\024\005 C-EMR)Tj /Span<>> BDC ( )Tj EMC (\227 49)Tj /Span<>> BDC ( )Tj EMC (\(96,1%\) \017)Tj /Span<>> BDC ( )Tj EMC (47)Tj /Span<>> BDC ( )Tj EMC (\(90,4%\) )Tj 0.375 Tw 23.244 23.138 Td [(\027\026\002\035\033\007\036\027\017\005, )0.5(\f\024\024\021\r\036\021\f\021\r\036\027\027\024, \024\007\027\026\022\024\ \030\026\035\017\004\017\016 \027\036 )]TJ -0.024 Tw T* (\002\t\035\017 \f\021\026\021\017\f\021\017\004\036\f\022\017 \027\026\004\ \017\n\t\n\017 \()Tj /T1_2 1 Tf 0 Tw (\032)Tj /T1_1 1 Tf -0.024 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,4\). \215\024\017\021\017\r\027\t\036 )Tj -0.02 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\024\021\027\024\001\036\027\017\017 \024\023\031\b\024\035\017 \035\026\ \021\036\030\026\035\034\027\t\036 \020\030\026\027\017\006\t \030\036\036\ \022\006\017\017 )Tj 0.04 Tw T* (\002\t\035\017 \024\021\n\036\004\036\027\t \r)Tj /Span<>> BDC ( )Tj EMC (4)Tj /Span<>> BDC ( )Tj EMC (\(7,7%\) \f\035\031\004\026\016\b)Tj /Span<>> BDC ( )Tj EMC (\227 \r)Tj /Span<>> BDC ( )Tj EMC (\024\f\027\024\r\027\024\005 \017)Tj /Span<>> BDC ( )Tj EMC (\r )Tj -0.035 Tw T* (3)Tj /Span<>> BDC ( )Tj EMC (\(5,9%\) \023\030\036\023\026\030\026\021\026\b)Tj /Span<>> BDC ( )Tj EMC (\227 \r)Tj /Span<>> BDC ( )Tj EMC (\022\024\027\021\030\024\035\034\027\024\005 \020\030\031\023\023\036 \(\ )Tj /T1_2 1 Tf 0 Tw (\032)Tj /T1_1 1 Tf -0.035 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (1,0\) )Tj 0 Tw T* (\(\230\026\002\035.)Tj /Span<>> BDC ( )Tj EMC (7\).)Tj 0.101 Tw T* (\200 4)Tj /Span<>> BDC ( )Tj EMC (\(7,7%\) \027\026\002\035\033\007\036\027\017\016\b \024\f\027\024\r\027\ \024\005 \017)Tj /Span<>> BDC ( )Tj EMC (\r 1)Tj /Span<>> BDC ( )Tj EMC (\(2,0%\) \f\035\031)Tj 0 Tw (-)Tj 0.136 Tw T* (\004\026\036 \r)Tj /Span<>> BDC ( )Tj EMC (\022\024\027\021\030\024\035\034\027\024\005 \020\030\031\023\023\036, \r\ \r\017\007\031 \007\036\235\024\030\n\026\006\017\017 \035\026\021\036)Tj 0 Tw (-)Tj 0.253 Tw T* [(\030\026\035\034\027\024\020\024 \022\030\026\016 \023\030\036\023\026\030\ \026\021\026 )0.5(\r\f\035\036\007\f\021\r\017\036 \021\036\030\n\017\004\036\f\022\024\020\ \024 )]TJ 0.109 Tw T* (\r\024\007\036\005\f\021\r\017\016, \004\036\021\022\024 \024\006\036\027\ \017\021\034 \020\030\026\027\017\006\t \030\036\036\022\006\017\017 \002\ \t\035\024 )Tj 0.324 Tw T* [(\026\021\030\031\007\027\017\021\036\035\034\027\024, )0.5(\004\021\024 \f\024\024\021\r\036\021\f\021\r\024\r\026\035\024 \022\030\ \017\021\036\030\017\033 )0.5(Rx )]TJ 0 Tw T* (\()Tj /T1_2 1 Tf (\032)Tj /T1_1 1 Tf 0.074 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,2\). \215\024)Tj /Span<>> BDC ( )Tj EMC (\030\036\031\035\034\021\026\021\026\n \020\017\f\021\024\035\024\020\017\ \004\036\f\022\024\020\024 \017\f\f\035\036\007\024)Tj 0 Tw (-)Tj 0.155 Tw T* (\r\026\027\017\016 \031\007\026\035\036\027\027\t\b \023\030\036\023\026\ \030\026\021\024\r, \002\024\035\034\001\017\027\f\021\r\024 \027\024\r\024\ \024\002)Tj 0 Tw (-)Tj 0.126 Tw T* (\030\026\024\r\026\027\017\005 \r)Tj /Span<>> BDC ( )Tj EMC (\024\f\027\024\r\027\024\005 \017)Tj /Span<>> BDC ( )Tj EMC (\022\024\027\021\030\024\035\034\027\024\005 \020\030\031\023\023\026\b \ \002\t\035\017 )Tj 0.595 Tw T* (\023\030\036\007\f\021\026\r\035\036\027\t \026\007\036\027\024\n\026\021\ \024\027\t\n\017 \027\024\r\024\024\002\030\026\024\r\026\027\017\016)Tj 0 Tw (-)Tj 0.2 Tw T* [(\n\017 )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC 2.391 0 Td [(\021\031\002\031\035\016\030\027\t\n )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 6.306 0 Td [(\021\031\002\031\035\016\030\027\024-\r\024\030\f\017\027\004\026\021\t\n\ )0.5(\021\017\023\026\n\017 )]TJ 0 Tw -8.697 -1.218 Td (\f\021\030\024\036\027\017\016.)Tj 0.184 Tw T* (\230\026\022\032\036, \031\004\017\021\t\r\026\016 \022\024\027\r\036\030\ \f\017\033 \r\n\036\001\026\021\036\035\034\f\021\r \r)Tj /Span<>> BDC ( )Tj EMC (\024\f\027\024\r)Tj 0 Tw (-)Tj 0.176 Tw T* (\027\024\005 \017)Tj /Span<>> BDC ( )Tj EMC (\022\024\027\021\030\024\035\034\027\024\005 \020\030\031\023\023\026\b \ \r)Tj /Span<>> BDC ( )Tj EMC (3)Tj /Span<>> BDC ( )Tj EMC (\(5,7%\) \017)Tj /Span<>> BDC ( )Tj EMC (6)Tj /Span<>> BDC ( )Tj EMC (\(11,7%\) )Tj 0.104 Tw T* [(\f\035\031\004\026\016\b, )0.6(\f\024\024\021\r\036\021\f\021\r\036\027\027\024, )0.6(\027\026\n\017 )0.5(\002\t\035 )0.5(\023\030\024\r\036\007\036\027 )0.5(\026\027\026\035\017 )]TJ 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0 Tw 9 0 0 9 42.5197 730.483 Tm (\020\004\206\f\t\204\004 5.)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf ( \206\026\032\026\013\024\031\032\025\t\024\025\013\026 \013\n\023\025\006\ \031\t\024\027\031\021\021\020\004 \033\032\025\016\021\026\013\n\027, \033\ \032\025\027\031\030\031\021\021\020\004 \013)Tj /Span<>> BDC ( )Tj EMC (\005\025\021\026\032\021\020\003 \016\021\026\006\031\021\025\002\003)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0 -1.2 TD [(T)48(able 5.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf [( Character)-36.9(istics of q)14.2(uantitativ)13(e features reduced to binar)-42.7(y v)16(alues)]TJ ET 0 0 0 1 K 0.5 w /GS2 gs q 1 0 0 1 42.5197 715.181 cm 0 0 m 99.463 0 l S Q q 1 0 0 1 42.7697 694.3618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 141.9823 715.181 cm 0 0 m 70.866 0 l S Q q 1 0 0 1 141.9823 694.3618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 212.8484 715.181 cm 0 0 m 70.866 0 l S Q q 1 0 0 1 212.8484 694.3618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 283.7146 715.181 cm 0 0 m 70.866 0 l S Q q 1 0 0 1 283.7146 694.3618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 354.5807 715.181 cm 0 0 m 70.866 0 l S Q q 1 0 0 1 354.5807 694.3618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 425.4468 715.181 cm 0 0 m 71.116 0 l S Q q 1 0 0 1 425.4468 694.3618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 496.313 694.3618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 42.5197 694.1118 cm 0 0 m 99.463 0 l S Q q 1 0 0 1 42.7697 682.9005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 141.9823 694.1118 cm 0 0 m 70.866 0 l S Q q 1 0 0 1 141.9823 682.9005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 212.8484 694.1118 cm 0 0 m 70.866 0 l S Q q 1 0 0 1 212.8484 682.9005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 283.7146 694.1118 cm 0 0 m 70.866 0 l S Q q 1 0 0 1 283.7146 682.9005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 354.5807 694.1118 cm 0 0 m 70.866 0 l S Q q 1 0 0 1 354.5807 682.9005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 425.4468 694.1118 cm 0 0 m 71.116 0 l S Q q 1 0 0 1 425.4468 682.9005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 682.9005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 682.6505 cm 0 0 m 99.463 0 l S Q q 1 0 0 1 42.7697 661.8392 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 141.9823 682.6505 cm 0 0 m 70.866 0 l S Q q 1 0 0 1 141.9823 661.8392 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 212.8484 682.6505 cm 0 0 m 70.866 0 l S Q q 1 0 0 1 212.8484 661.8392 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 283.7146 682.6505 cm 0 0 m 70.866 0 l S Q q 1 0 0 1 283.7146 661.8392 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 354.5807 682.6505 cm 0 0 m 70.866 0 l S Q q 1 0 0 1 354.5807 661.8392 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 425.4468 682.6505 cm 0 0 m 71.116 0 l S Q q 1 0 0 1 425.4468 661.8392 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 496.313 661.8392 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 42.5197 661.5892 cm 0 0 m 99.463 0 l S Q q 1 0 0 1 141.9823 661.5892 cm 0 0 m 70.866 0 l S Q q 1 0 0 1 212.8484 661.5892 cm 0 0 m 70.866 0 l S Q q 1 0 0 1 283.7146 661.5892 cm 0 0 m 70.866 0 l S Q q 1 0 0 1 354.5807 661.5892 cm 0 0 m 70.866 0 l S Q q 1 0 0 1 425.4468 661.5892 cm 0 0 m 71.116 0 l S Q BT /GS1 gs /T1_3 1 Tf 8 0 0 8 64.8004 701.7465 Tm (\221\004\006\004\220\003\r\006\t\217\003\t\220\004)Tj 11.048 0 Td (\020\002\201\220\004 \002\003\217\r\201\220\t)Tj 7.961 0 Td (\030\210\217\003\t\003\r\f\001\b\002\217\003\001)Tj 9.395 0 Td (\255\212\r\204\t\226\t\201\b\002\217\003\001)Tj 9.357 0.6 Td (\200\f\002\227\004\240\001 \212\002\240 )Tj 1.293 -1.2 Td (\220\006\t\002\005)Tj 7.145 0.6 Td (\034\b\240\r\220\217 \023\002\240\r\b\004)Tj /T1_1 1 Tf -48.599 -2.033 Td (\217\026\n\036\030 \024\023\031\b\024\035\017, \n\n)Tj 15.517 0 Td (\241)Tj /Span<>> BDC ( )Tj EMC (2,7)Tj 8.975 0 Td (55,6)Tj 8.858 0 Td (75,5)Tj 7.533 0 Td (0,64)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (0,10)Tj 10.184 0 Td (0,31)Tj -51.067 -1.433 Td (\215\030\024\007\024\035\032\017\021\036\035\034\027\024\f\021\034 )Tj T* (\r\n\036\001\026\021\036\035\034\f\021\r\026, \n\017\027.)Tj 15.267 1.2 Td (\241)Tj /Span<>> BDC ( )Tj EMC (47,5)Tj 9.225 0 Td (77,8)Tj 8.858 0 Td (51,1)Tj 7.533 0 Td (0,72)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (0,08)Tj 10.184 0 Td (0,29)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 9 0 0 9 42.5197 644.87 Tm (\020\004\206\f\t\204\004 6.)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf ( Cox-\032\031\202\032\031\t\t\025\n\021\021\020\017 \026\021\026\023\025\ \016 \f\026\013\024\n\032\n\027, \027\023\025\002\007\211\025\004 \021\026\ )Tj /Span<>> BDC ( )Tj EMC [(\013\n\021\027\031)0.5(\032\t\025\007 \r\021\030\n\t\013\n\033\025\006\031\t\013\n\202\n \027\003\ \031\001\026\024\031\023\022\t\024\027\026)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0 -1.2 TD [(T)48(able 6)16(.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf [( Co)14.1(x-reg)14(ression analysis of factors in\234uencing the con)11.4(v)12.9(ersion of endoscopic inter)-42(v)13(ention)]TJ ET /GS2 gs q 1 0 0 1 42.5197 629.568 cm 0 0 m 215.683 0 l S Q q 1 0 0 1 42.7697 618.0988 cm 0 0 m 0 11.219 l S Q q 1 0 0 1 258.2028 629.568 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 258.2028 618.3488 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 334.7382 629.568 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 377.2579 629.568 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 453.7933 629.568 cm 0 0 m 42.77 0 l S Q q 1 0 0 1 496.313 618.3488 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 42.7697 606.6296 cm 0 0 m 0 11.469 l S Q q 1 0 0 1 257.9528 618.0988 cm 0 0 m 76.785 0 l S Q q 1 0 0 1 258.2028 606.8796 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 334.7382 618.0988 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 377.2579 618.0988 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 377.2579 606.8796 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 453.7933 618.0988 cm 0 0 m 42.77 0 l S Q q 1 0 0 1 496.313 606.8796 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 42.7697 595.4103 cm 0 0 m 0 11.219 l S Q q 1 0 0 1 257.9528 606.6296 cm 0 0 m 76.785 0 l S Q q 1 0 0 1 258.2028 595.4103 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 334.7382 606.6296 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 334.7382 595.4103 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 377.2579 606.6296 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 377.2579 595.4103 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 453.7933 606.6296 cm 0 0 m 42.77 0 l S Q q 1 0 0 1 453.7933 595.4103 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 496.313 595.4103 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 42.5197 595.1603 cm 0 0 m 215.683 0 l S Q q 1 0 0 1 42.7697 583.949 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 258.2028 595.1603 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 258.2028 583.949 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 334.7382 595.1603 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 334.7382 583.949 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 377.2579 595.1603 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 377.2579 583.949 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 453.7933 595.1603 cm 0 0 m 42.77 0 l S Q q 1 0 0 1 453.7933 583.949 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 583.949 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 583.699 cm 0 0 m 215.683 0 l S Q q 1 0 0 1 42.7697 572.4878 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 258.2028 583.699 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 258.2028 572.4878 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 334.7382 583.699 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 334.7382 572.4878 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 377.2579 583.699 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 377.2579 572.4878 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 453.7933 583.699 cm 0 0 m 42.77 0 l S Q q 1 0 0 1 453.7933 572.4878 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 572.4878 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 572.2378 cm 0 0 m 215.683 0 l S Q q 1 0 0 1 42.7697 561.0265 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 258.2028 572.2378 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 258.2028 561.0265 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 334.7382 572.2378 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 334.7382 561.0265 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 377.2579 572.2378 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 377.2579 561.0265 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 453.7933 572.2378 cm 0 0 m 42.77 0 l S Q q 1 0 0 1 453.7933 561.0265 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 561.0265 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 560.7765 cm 0 0 m 215.683 0 l S Q q 1 0 0 1 42.7697 549.5652 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 258.2028 560.7765 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 258.2028 549.5652 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 334.7382 560.7765 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 334.7382 549.5652 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 377.2579 560.7765 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 377.2579 549.5652 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 453.7933 560.7765 cm 0 0 m 42.77 0 l S Q q 1 0 0 1 453.7933 549.5652 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 549.5652 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 549.3152 cm 0 0 m 215.683 0 l S Q q 1 0 0 1 42.7697 538.1039 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 258.2028 549.3152 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 258.2028 538.1039 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 334.7382 549.3152 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 334.7382 538.1039 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 377.2579 549.3152 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 377.2579 538.1039 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 453.7933 549.3152 cm 0 0 m 42.77 0 l S Q q 1 0 0 1 453.7933 538.1039 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 538.1039 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 537.8539 cm 0 0 m 215.683 0 l S Q q 1 0 0 1 42.7697 526.6426 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 258.2028 537.8539 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 258.2028 526.6426 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 334.7382 537.8539 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 334.7382 526.6426 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 377.2579 537.8539 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 377.2579 526.6426 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 453.7933 537.8539 cm 0 0 m 42.77 0 l S Q q 1 0 0 1 453.7933 526.6426 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 526.6426 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 526.3926 cm 0 0 m 215.683 0 l S Q q 1 0 0 1 42.7697 515.1813 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 258.2028 526.3926 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 258.2028 515.1813 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 334.7382 526.3926 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 334.7382 515.1813 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 377.2579 526.3926 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 377.2579 515.1813 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 453.7933 526.3926 cm 0 0 m 42.77 0 l S Q q 1 0 0 1 453.7933 515.1813 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 515.1813 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 514.9313 cm 0 0 m 215.683 0 l S Q q 1 0 0 1 42.7697 503.7201 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 258.2028 514.9313 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 258.2028 503.7201 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 334.7382 514.9313 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 334.7382 503.7201 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 377.2579 514.9313 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 377.2579 503.7201 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 453.7933 514.9313 cm 0 0 m 42.77 0 l S Q q 1 0 0 1 453.7933 503.7201 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 503.7201 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 503.4701 cm 0 0 m 215.683 0 l S Q q 1 0 0 1 258.2028 503.4701 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 334.7382 503.4701 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 377.2579 503.4701 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 453.7933 503.4701 cm 0 0 m 42.77 0 l S Q BT /GS1 gs /T1_3 1 Tf 8 0 0 8 137.8024 609.4642 Tm (\203\004\220\003\002\006)Tj 27.586 1.434 Td (\021\002\b\r\006\217\t\235)Tj -8.681 -1.434 Td (\017\240\b\002\226\004\220\003\002\006\b\013\005)Tj 14.632 0 Td (\215\b\002\n\002\226\004\220\003\002\006\b\013\005)Tj -16.258 -1.434 Td (\017\016 \031\034 95%)Tj /T1_4 1 Tf 9.737 0.001 Td (p)Tj /T1_3 1 Tf 5.145 -0.001 Td (\017\016 \031\034 95%)Tj /T1_4 1 Tf 9.737 0.001 Td (p)Tj /T1_1 1 Tf -53.422 -1.433 Td (\217\026\n\036\030 \024\023\031\b\024\035\017)Tj /Span<>> BDC ( )Tj EMC (\241)Tj /Span<>> BDC ( )Tj EMC (2,7 \n\n, \036\f\021\034/\027\036\021)Tj 28.251 0 Td (2,08 90,3\22614,2\))Tj 9.955 0 Td (0,4)Tj -38.207 -1.433 Td (\215\030\024\007\024\035\032\017\021\036\035\034\027\024\f\021\034 \r\n\036\ \001\026\021\036\035\034\f\021\r\026)Tj /Span<>> BDC ( )Tj EMC (\241)Tj /Span<>> BDC ( )Tj EMC (47,5 \n\017\027., \036\f\021\034/\027\036\021)Tj 28.316 0 Td (2,7)Tj /Span<>> BDC ( )Tj EMC (\(0,36\22620,6\))Tj 9.89 0 Td (0,3)Tj -38.207 -1.433 Td (\203\036\031\007\024\002\027\024\036 \030\026\f\023\024\035\024\032\036\027\ \017\036 \024\023\031\b\024\035\017, \036\f\021\034/\027\036\021)Tj 28.066 0 Td (20,9)Tj /Span<>> BDC ( )Tj EMC (\(2,5\226175,6\))Tj 9.64 0 Td (0,002)Tj 5.241 0 Td (18,3)Tj /Span<>> BDC ( )Tj EMC (\(1,9\226176,8\))Tj 9.89 0 Td (0,01)Tj -52.839 -1.433 Td (\025\030\031\023\027\t\036 \f\024\f\031\007\t \023\024\007\f\035\017\017\ \f\021\024\020\024 \f\035\024\016, \036\f\021\034/\027\036\021)Tj 28.566 0 Td (3,4)Tj /Span<>> BDC ( )Tj EMC (\(0,7\22615,5\))Tj 9.64 0 Td (0,1)Tj -38.207 -1.433 Td (\222\002\t\021\024\004\027\024\036 \024\021\035\024\032\036\027\017\036\ \032\017\030\026 \r)Tj /Span<>> BDC ( )Tj EMC (\023\024\007\f\035\017\017\f\021\024\n \f\035\024\036, \036\f\021\034/\027\ \036\021)Tj 28.566 0 Td (3,6)Tj /Span<>> BDC ( )Tj EMC (\(0,8\22614,9\))Tj 9.39 0 Td (0,08)Tj -37.957 -1.433 Td (\205\017\002\030\024 \023\024\007\f\035\017\017\f\021\024\020\024 \f\035\ \024\016, \036\f\021\034/\027\036\021)Tj 28.566 0 Td (4,9)Tj /Span<>> BDC ( )Tj EMC (\(1,2\22620,2\))Tj 9.39 0 Td (0,03)Tj 5.491 0 Td (4,4)Tj /Span<>> BDC ( )Tj EMC (\(0,8\22623,2\))Tj 9.39 0 Td (0,08)Tj -52.839 -1.433 Td (\211\f\017\035\036\027\027\026\016 \023\036\030\017\f\021\026\035\034\021\ \017\022\026 \022\017\001\022\017, \036\f\021\034/\027\036\021)Tj 28.316 0 Td (15,8)Tj /Span<>> BDC ( )Tj EMC (\(3,1\22683,1\))Tj 9.39 0 Td (0,001)Tj -37.707 -1.433 Td (\222\027\021\030\026\024\023\036\030\026\006\017\024\027\027\t\036 \024\f\ \035\024\032\027\036\027\017\016, \036\f\021\034/\027\036\021)Tj 28.316 0 Td (26,6)Tj /Span<>> BDC ( )Tj EMC (\(2,2\22633,1\))Tj 9.64 0 Td (0,02)Tj 4.741 0 Td (37,5)Tj /Span<>> BDC ( )Tj EMC (\(1,1\2261317,9\))Tj 10.14 0 Td (0,04)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 9 0 0 9 42.5198 486.7508 Tm (\020\004\206\f\t\204\004 7.)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf [( \212\031\016\205\023\022\024\026\024\020 \033\026\024\n\003\n\032\f\n\023\ \n\202\025\006\031\t\013\n\202\n \025\t\t\023\031\030\n\027\026\021\025\002\ \n\033\031\032\026\203\025\n\021)0.5(\021\020\004 \033\032\031\033\026\032\026\024\n\027 \027)]TJ /Span<>> BDC ( )Tj EMC (\202\032\205\033\033\026\004)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0 -1.2 TD [(T)48(able 7)124(.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf [( R)21(esults of the pathomor)-17.7(phology of specimens in g)14.2(roups)]TJ ET /GS2 gs q 1 0 0 1 42.5198 471.4488 cm 0 0 m 181.667 0 l S Q q 1 0 0 1 42.7698 450.6296 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 224.1871 471.4488 cm 0 0 m 102.047 0 l S Q q 1 0 0 1 224.1871 450.6296 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 326.2343 471.4488 cm 0 0 m 102.047 0 l S Q q 1 0 0 1 326.2343 450.6296 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 428.2816 471.4488 cm 0 0 m 68.281 0 l S Q q 1 0 0 1 428.2816 450.6296 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 496.3131 450.6296 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 42.5198 450.3796 cm 0 0 m 181.667 0 l S Q q 1 0 0 1 42.7698 439.1683 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 224.1871 450.3796 cm 0 0 m 102.047 0 l S Q q 1 0 0 1 224.1871 439.1683 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 326.2343 450.3796 cm 0 0 m 102.047 0 l S Q q 1 0 0 1 326.2343 439.1683 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 428.2816 450.3796 cm 0 0 m 68.281 0 l S Q q 1 0 0 1 428.2816 439.1683 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.3131 439.1683 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5198 438.9183 cm 0 0 m 181.667 0 l S Q q 1 0 0 1 42.7698 427.707 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 224.1871 438.9183 cm 0 0 m 102.047 0 l S Q q 1 0 0 1 326.2343 438.9183 cm 0 0 m 102.047 0 l S Q q 1 0 0 1 428.2816 438.9183 cm 0 0 m 68.281 0 l S Q q 1 0 0 1 496.3131 427.707 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5198 427.457 cm 0 0 m 181.667 0 l S Q q 1 0 0 1 42.7698 416.2458 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 224.1871 427.457 cm 0 0 m 102.047 0 l S Q q 1 0 0 1 224.1871 416.2458 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 326.2343 427.457 cm 0 0 m 102.047 0 l S Q q 1 0 0 1 326.2343 416.2458 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 428.2816 427.457 cm 0 0 m 68.281 0 l S Q q 1 0 0 1 428.2816 416.2458 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.3131 416.2458 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5198 415.9958 cm 0 0 m 181.667 0 l S Q q 1 0 0 1 42.7698 404.7845 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 224.1871 415.9958 cm 0 0 m 102.047 0 l S Q q 1 0 0 1 224.1871 404.7845 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 326.2343 415.9958 cm 0 0 m 102.047 0 l S Q q 1 0 0 1 326.2343 404.7845 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 428.2816 415.9958 cm 0 0 m 68.281 0 l S Q q 1 0 0 1 428.2816 404.7845 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.3131 404.7845 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5198 404.5345 cm 0 0 m 181.667 0 l S Q q 1 0 0 1 42.7698 393.3232 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 224.1871 404.5345 cm 0 0 m 102.047 0 l S Q q 1 0 0 1 224.1871 393.3232 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 326.2343 404.5345 cm 0 0 m 102.047 0 l S Q q 1 0 0 1 326.2343 393.3232 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 428.2816 404.5345 cm 0 0 m 68.281 0 l S Q q 1 0 0 1 428.2816 393.3232 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.3131 393.3232 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5198 393.0732 cm 0 0 m 181.667 0 l S Q q 1 0 0 1 42.7698 381.8619 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 224.1871 393.0732 cm 0 0 m 102.047 0 l S Q q 1 0 0 1 326.2343 393.0732 cm 0 0 m 102.047 0 l S Q q 1 0 0 1 428.2816 393.0732 cm 0 0 m 68.281 0 l S Q q 1 0 0 1 496.3131 381.8619 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5198 381.6119 cm 0 0 m 181.667 0 l S Q q 1 0 0 1 42.7698 370.4006 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 224.1871 381.6119 cm 0 0 m 102.047 0 l S Q q 1 0 0 1 224.1871 370.4006 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 326.2343 381.6119 cm 0 0 m 102.047 0 l S Q q 1 0 0 1 326.2343 370.4006 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 428.2816 381.6119 cm 0 0 m 68.281 0 l S Q q 1 0 0 1 428.2816 370.4006 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.3131 370.4006 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5198 370.1506 cm 0 0 m 181.667 0 l S Q q 1 0 0 1 42.7698 358.9393 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 224.1871 370.1506 cm 0 0 m 102.047 0 l S Q q 1 0 0 1 224.1871 358.9393 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 326.2343 370.1506 cm 0 0 m 102.047 0 l S Q q 1 0 0 1 326.2343 358.9393 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 428.2816 370.1506 cm 0 0 m 68.281 0 l S Q q 1 0 0 1 428.2816 358.9393 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.3131 358.9393 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5198 358.6893 cm 0 0 m 181.667 0 l S Q q 1 0 0 1 42.7698 347.4781 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 224.1871 358.6893 cm 0 0 m 102.047 0 l S Q q 1 0 0 1 224.1871 347.4781 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 326.2343 358.6893 cm 0 0 m 102.047 0 l S Q q 1 0 0 1 326.2343 347.4781 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 428.2816 358.6893 cm 0 0 m 68.281 0 l S Q q 1 0 0 1 428.2816 347.4781 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.3131 347.4781 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5198 347.2281 cm 0 0 m 181.667 0 l S Q q 1 0 0 1 224.1871 347.2281 cm 0 0 m 102.047 0 l S Q q 1 0 0 1 326.2343 347.2281 cm 0 0 m 102.047 0 l S Q q 1 0 0 1 428.2816 347.2281 cm 0 0 m 68.281 0 l S Q BT /GS1 gs /T1_3 1 Tf 8 0 0 8 116.7387 458.0142 Tm (\200\004\006\004\214\r\003\006)Tj 18.493 0.6 Td (C-EMR)Tj -0.453 -1.2 Td (\()Tj /T1_4 1 Tf (n)Tj /T1_3 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (52\))Tj 13.735 1.2 Td (ESD)Tj -0.979 -1.2 Td (\()Tj /T1_4 1 Tf (n)Tj /T1_3 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (51\))Tj /T1_4 1 Tf 12.14 0.6 Td (p)Tj /T1_1 1 Tf -51.827 -2.033 Td (\217\036\036\022\006\017\016 \036\007\017\027\t\n \002\035\024\022\024\n\ , )Tj /T1_2 1 Tf (n)Tj /T1_1 1 Tf ( \(%\))Tj 26.492 0 Td (47)Tj /Span<>> BDC ( )Tj EMC (\(90,4%\))Tj 12.756 0 Td (49)Tj /Span<>> BDC ( )Tj EMC (\(96,1%\))Tj 11.996 0 Td (0,4*)Tj -51.244 -1.433 Td (\206\030\026\027\017\006\t \030\036\036\022\006\017\017, )Tj /T1_2 1 Tf (n)Tj /T1_1 1 Tf ( \(%\))Tj 0 -1.433 TD (R0)Tj 26.492 0 Td (40)Tj /Span<>> BDC ( )Tj EMC (\(76,9%\))Tj 12.756 0 Td (45)Tj /Span<>> BDC ( )Tj EMC (\(88,2%\))Tj 11.996 0 Td (0,2*)Tj -51.244 -1.433 Td (R1)Tj 26.992 0 Td (4)Tj /Span<>> BDC ( )Tj EMC (\(7,7%\))Tj 12.756 0 Td (3)Tj /Span<>> BDC ( )Tj EMC (\(5,9%\))Tj 11.496 0 Td (1,0*)Tj -51.244 -1.433 Td (R\b)Tj 26.992 0 Td (4)Tj /Span<>> BDC ( )Tj EMC (\(7,7%\))Tj 12.756 0 Td (1)Tj /Span<>> BDC ( )Tj EMC (\(2,0%\))Tj 11.496 0 Td (0,4*)Tj -51.244 -1.433 Td (\206\017\f\021\024\035\024\020\017\004\036\f\022\026\016 \f\021\030\031\022\ \021\031\030\026 \027\024\r\024\024\002\030\026\024\r\026\027\017\005, \ )Tj /T1_2 1 Tf (n)Tj /T1_1 1 Tf ( \(%\))Tj T* (\230\031\002\031\035\016\030\027\026\016 \026\007\036\027\024\n\026)Tj 26.492 0 Td (21)Tj /Span<>> BDC ( )Tj EMC (\(40,4%\))Tj 12.756 0 Td (16)Tj /Span<>> BDC ( )Tj EMC (\(31,4%\))Tj 11.746 0 Td (0,4**)Tj -50.994 -1.433 Td (\230\031\002\031\035\016\030\027\024-\r\024\030\f\017\027\004\026\021\026\ \016 \026\007\036\027\024\n\026)Tj 26.492 0 Td (22)Tj /Span<>> BDC ( )Tj EMC (\(42,3%\))Tj 13.135 0 Td (17)Tj /Span<>> BDC ( )Tj EMC (\(33,3\))Tj 11.366 0 Td (0,4**)Tj -50.994 -1.433 Td (\003\031\002\004\026\021\024\036 \024\002\030\026\024\r\026\027\017\036\ )Tj 26.742 0 Td (9)Tj /Span<>> BDC ( )Tj EMC (\(17,3%\))Tj 12.506 0 Td (18)Tj /Span<>> BDC ( )Tj EMC (\(35,3%\))Tj 11.496 0 Td (0,04**)Tj /T1_2 1 Tf 7 0 0 7 42.5198 335.7434 Tm (\032\025\003\031\006\026\021\025\031: \032*)Tj /Span<>> BDC ( )Tj EMC (\227 \024\n\006\021\020\017 \013\032\025\024\031\032\025\017 \225\025\001\ \031\032\026; \032**)Tj /Span<>> BDC ( )Tj EMC (\227 \013\032\025\024\031\032\025\017 \232)Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\033\030\031\030\213\b)-20.9(\035\231\213\233\t \021\032)50(\b)42(\032\231\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj /T1_5 1 Tf 25 0 0 25 512.8894 56.0378 Tm (27)Tj ET endstream endobj 2357 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.132 Tw 10 0 0 10 70.8661 444.7359 Tm (\004\021\024 \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 ESD \004\026\013\036 \r\f\021\030\036\004\026\035\ \017\f\034 \023\026\006\017\036\027\021\t \f)Tj /Span<>> BDC ( )Tj EMC (\235\017)Tj 0 Tw (-)Tj 0.331 Tw 0 -1.218 TD [(\002\030\024\024\n \023\024\007\f\035\017\017\f\021\024\020\024 \f\035\ \024\016 )0.5(\f\021\036\027\022\017 \022\017\001\022\017 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC (\024\027\036 )Tj 0.023 Tw T* (\024\023\031\b\024\035\017)Tj /Span<>> BDC ( )Tj EMC (\227 21)Tj /Span<>> BDC ( )Tj EMC (\(41,2%\) \027\026\002\035\033\007\036\027\017\036, \026)Tj /Span<>> BDC ( )Tj EMC (\r \020\030\031\023\023\036 C-EMR )Tj 0.041 Tw T* (\220\021\024 \026\030\036\020\017\f\021\030\017\030\024\r\026\027\024 \r\ )Tj /Span<>> BDC ( )Tj EMC (3)Tj /Span<>> BDC ( )Tj EMC (\(5,8%\) \f\035\031\004\026\016\b \()Tj /T1_1 1 Tf 0 Tw (\032)Tj /T1_0 1 Tf 0.041 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,001\). )Tj -0.031 Tw T* (\212\026\027\027\026\016 \030\026\027\017\006\026, \023\024)Tj /Span<>> BDC ( )Tj EMC (\027\026\001\036\n\031 \n\027\036\027\017\033, \024\002\255\016\f\027\016\ \036\021\f\016 \021\036\n, )Tj 0.073 Tw T* (\004\021\024 \023\030\017)Tj /Span<>> BDC ( )Tj EMC [(\r\t\023\024\035\027\036\027\017\017 \220\027\007\024\f\022\024\023\017\004\ \036\f\022\024\005 )0.5(\023\024\007\f\035\017\017\f\021\024\005 )]TJ 0.078 Tw T* (\007\017\f\f\036\022\006\017\017, \026)Tj /Span<>> BDC ( )Tj EMC (\017\n\036\027\027\024 \r)Tj /Span<>> BDC ( )Tj EMC (\b\024\007\036 \024\021\f\036\023\026\030\024\r\022\017 \024\023\031\b\024\ \035\017 \024\021 )Tj 0.003 Tw T* [(\n\t\001\036\004\027\024\005 )0.6(\024\002\024\035\024\004\022\017 )0.5(\f\021\036\027\022\017 )0.5(\022\017\001\022\017, )0.5(\r\017\031\026\035\034\027\024\n\031 )0.6(\022\024\027)]TJ 0 Tw (-)Tj 0.098 Tw T* (\021\030\024\035\033 \023\024\007\007\026\036\021\f\016 \023\024\007\f\035\ \017\017\f\021\t\005 \f\035\024\005 \027\026)Tj /Span<>> BDC ( )Tj EMC (\r\f\036\n \023\030\024\021\016)Tj 0 Tw (-)Tj 0.053 Tw T* (\032\036\027\017\017, \004\021\024 \023\024\r\024\035\016\036\021 \r\030\ \026\004\031-\220\027\007\024\f\022\024\023\017\f\021\031 \f)Tj /Span<>> BDC ( )Tj EMC (\r\t\f\024\022\024\005 )Tj 0.167 Tw T* (\r\036\030\024\016\021\027\024\f\021\034\033 \024\006\036\027\017\021\034\ \027\026\035\017\004\017\036 \021\036\b \017\035\017 \017\027\t\b \017\ \n\036)Tj 0 Tw (-)Tj 0.14 Tw T* (\027\036\027\017\005. \230\024\020\007\026 \022\026\022 \r)Tj /Span<>> BDC ( )Tj EMC (\f\035\031\004\026\036 \017\f\023\024\035\034\024\r\026\027\017\016 \n\036\ \021\024\007\017\022\017 )Tj 0.051 Tw T* (C-EMR \023\024\f\035\036 \r\t\023\024\035\027\036\027\017\016 \006\017\030\ \022\031\035\016\030\027\024\020\024 \030\026\030\036\026 \031\007\026\ )Tj 0 Tw (-)Tj 0.074 Tw T* [(\036\021\f\016 )0.5(\r\017\031\026\035\017\017\030\024\r\026\021\034 )0.5(\021\024\035\034\022\024 )0.6(\n\026\035\031\033 )0.5(\004\026\f\021\034 )0.5(\023\024\007\f\035\017\017)]TJ 0 Tw (-)Tj T* (\f\021\024\020\024 \f\035\024\016 \(\230\026\002\035.)Tj /Span<>> BDC ( )Tj EMC (4\).)Tj 0.346 Tw T* (\210\021\n\036\004\036\027\024, \004\021\024 \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \220\027\007\024\f\022\024\023\017\004\036\f\022\ \024\005 \023\024\007\f\035\017)Tj 0 Tw (-)Tj 0.106 Tw T* (\017\f\021\024\005 \007\017\f\f\036\022\006\017\017 \r)Tj /Span<>> BDC ( )Tj EMC (6/51 \(11,7%\) \f\035\031\004\026\016\b \002\t\035\026 \024\f\031)Tj 0 Tw (-)Tj 0.433 Tw T* (\013\036\f\021\r\035\036\027\026 \022\024\027\r\036\030\f\017\016 \r\n\036\ \001\026\021\036\035\034\f\021\r\026: \031)Tj /Span<>> BDC ( )Tj EMC (4)Tj /Span<>> BDC ( )Tj EMC (\(7,8%\) )Tj 0.132 Tw T* (\023\026\006\017\036\027\021\024\r)Tj /Span<>> BDC ( )Tj EMC (\227 \r)Tj /Span<>> BDC ( )Tj EMC (\n\036\021\024\007 C-EMR \017)Tj /Span<>> BDC ( )Tj EMC (\r 2)Tj /Span<>> BDC ( )Tj EMC (\(3,9%\) \027\026\002\035\033\007\036)Tj 0 Tw (-)Tj 0.085 Tw T* (\027\017\016\b)Tj /Span<>> BDC ( )Tj EMC (\227 \r)Tj /Span<>> BDC ( )Tj EMC (\n\036\021\024\007 \235\030\026\020\n\036\027\021\026\030\027\024\005 \023\ \036\021\035\036\r\024\005 \030\036\036\022\006\017\017. )Tj 0.133 Tw T* (\215\030\017\004\017\027\024\005 \022\024\027\r\036\030\f\017\005 \r)Tj /Span<>> BDC ( )Tj EMC (\021\030\036\b \027\026\002\035\033\007\036\027\017\016\b \f\021\026\035\ \024 \027\036)Tj 0 Tw (-)Tj 0.038 Tw T* (\031\007\024\002\027\024\036 \007\035\016 \r\t\023\024\035\027\036\027\017\ \016 ESD \030\026\f\023\024\035\024\032\036\027\017\036 \027\024\r\024\024\ \002)Tj 0 Tw (-)Tj 0.018 Tw T* (\030\026\024\r\026\027\017\016 \(\r \024\027\036 \027\017\032\027\036\005\ \020\031\002\t \017\035\036\024\006\036\022\026\035\034\027\024\020\024\ \022\035\026)Tj 0 Tw (-)Tj 0.176 Tw T* (\023\026\027\026, \023\024)Tj /Span<>> BDC ( )Tj EMC (\026\007\027\036\005 \023\024\r\036\030\b\027\024\f\021\017 \f\022\035\026\ \007\022\017\) \r)Tj /Span<>> BDC ( )Tj EMC (\f\024\004\036\021\026\027\017\017 )Tj 0.101 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\235\017\002\030\024\024\n \017)Tj /Span<>> BDC ( )Tj EMC (\017\002\t\021\024\004\027\t\n \024\021\035\024\032\036\027\017\036\n \032\ \017\030\026 \r)Tj /Span<>> BDC ( )Tj EMC (\023\024\007)Tj 0 Tw (-)Tj 0.104 Tw T* (\f\035\017\017\f\021\024\n \f\035\024\036 \f\021\036\027\022\017 \022\017\ \001\022\017, \r)Tj /Span<>> BDC ( )Tj EMC (\021\030\036\b \007\030\031\020\017\b \027\026\002\035\033)Tj 0 Tw (-)Tj 0.398 Tw T* (\007\036\027\017\016\b \031\f\017\035\036\027\027\026\016 \023\036\030\017\ \f\021\026\035\034\021\017\022\026 \022\017\001\022\017 \027\026)Tj /Span<>> BDC ( )Tj EMC (\235\024\027\036 )Tj 0.222 Tw T* (\002\030\033\001\027\024\020\024 \021\017\023\026 \007\t\b\026\027\017\016\ . \202)Tj /Span<>> BDC ( )Tj EMC (\r \020\030\031\023\023\036 \220\027\007\024\f\022\024\023\017\004\036)Tj 0 Tw (-)Tj 0.215 Tw T* (\f\022\024\005 \030\036\036\022\006\017\017 \f\035\017\017\f\021\024\005\ \f)Tj /Span<>> BDC ( )Tj EMC (\006\017\030\022\031\035\016\030\027\t\n \030\026\030\036\024\n )Tj 0.239 Tw T* (\022\024\027\r\036\030\f\017\016 \002\t\035\026 \024\021\n\036\004\036\027\ \026 \r)Tj /Span<>> BDC ( )Tj EMC (3/52 \(5,8%\) \027\026\002\035\033\007\036)Tj 0 Tw (-)Tj 0.066 Tw T* [(\027\017\016\b. )0.5(\211)]TJ /Span<>> BDC ( )Tj EMC (2)Tj /Span<>> BDC ( )Tj EMC 4.131 0 Td (\(3,8%\) \002\024\035\034\027\t\b)Tj /Span<>> BDC ( )Tj EMC 6.773 0 Td (\227 \r)Tj /Span<>> BDC ( )Tj EMC 2.071 0 Td [(\n\036\021\024\007 )0.5(\235\030\026\020\n\036\027\021\026\030\027\024\005 )]TJ 0.133 Tw 10.269 36.534 Td (\023\036\021\035\036\r\024\005 \030\036\036\022\006\017\017 \017-\026\ \027\036\031\007\024\002\027\024\020\024 \030\026\f\023\024\035\024\032\ \036\027\017\016 )Tj 0.099 Tw T* (\024\023\031\b\024\035\017 \(\023\024 \002\030\t\032\036\036\004\027\024\ \n\031 \022\030\026\033 \r)Tj /Span<>> BDC ( )Tj EMC (\023\036\004\036\027\024\004\027\024\n \017)Tj /Span<>> BDC ( )Tj EMC (\f\036)Tj 0 Tw (-)Tj 0.08 Tw T* (\035\036\036\027\024\004\027\024\n \017\020\017\002\026\b \024\002\024\ \007\024\004\027\024\005 \022\017\001\022\017\), \026)Tj /Span<>> BDC ( )Tj EMC (\031 1)Tj /Span<>> BDC ( )Tj EMC (\(2,0%\) )Tj 0.059 Tw T* (\002\024\035\034\027\024\020\024)Tj /Span<>> BDC ( )Tj EMC (\227 \r)Tj /Span<>> BDC ( )Tj EMC (\023\024\035\024\f\021\027\031\033 \024\023\036\030\026\006\017\033 \023\ \024)Tj /Span<>> BDC ( )Tj EMC (\023\030\017\004\017\027\036 \030\026)Tj 0 Tw (-)Tj 0.068 Tw T* (\r\017\r\001\036\020\024\f\016 \017\027\021\030\026\024\023\036\030\026\006\ \017\024\027\027\024\020\024 \022\030\024\r\024\021\036\004\036\027\017\016\ , \022\024\021\024)Tj 0 Tw (-)Tj T* (\030\024\036 \027\036 \031\007\026\035\024\f\034 \024\f\021\026\027\024\r\ \017\021\034 \220\027\007\024\f\022\024\023\017\004\036\f\022\017.)Tj 0.227 Tw T* (\211\004\017\021\t\r\026\016 \023\030\024\017\024\001\036\007\001\031\033\ \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\026\b \022\024\027\r\036\030\f\017\033 \220\027)Tj 0 Tw (-)Tj 0.16 Tw T* [(\007\024\f\022\024\023\017\004\036\f\022\024\020\024 \r\n\036\001\026\021\ \036\035\034\f\021\r\026, )0.5(\027\026\n\017 \002\t\035 \023\030\024\r\036\007\036\027 )]TJ 0.194 Tw T* (\026\027\026\035\017 \235\026\022\021\024\030\024\r, \022\024\021\024\030\ \t\036 \023\024\021\036\027\006\017\026\035\034\027\024 \n\024\020\035\017\ \023\024)Tj 0 Tw (-)Tj T* (\r\035\017\016\021\034 \027\026)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\021 \017\f\b\024\007.)Tj 0.135 Tw T* (\200 \022\026\004\036\f\021\r\036 \235\026\022\021\024\030\024\r \030\017\ \f\022\026 \027\026\n\017 \002\t\035\017 \023\030\024\026\027\026\035\017\ \017)Tj 0 Tw (-)Tj 0.335 Tw T* (\030\024\r\026\027\t \021\026\022\017\036 \023\024\022\026\026\021\036\035\ \017, \022\026\022 \030\026\n\036\030 \031\007\026\035\016\036\n\024\020\ \024 )Tj 0.186 Tw T* [(\027\024\r\024\024\002\030\026\024\r\026\027\017\016, )0.6(\027\026\035\017\004\017\036 )0.6(\022\030\031\023\027\t\b )0.5(\f\024\f\031\007\024\r )0.6(\r)]TJ /Span<>> BDC ( )Tj EMC 20.262 0 Td (\023\024\007)Tj 0 Tw (-)Tj 0.221 Tw -20.262 -1.218 Td [(\f\035\017\017\f\021\024\n \f\035\024\036, \027\036\031\007\024\002\027\ \024\036 \030\026\f\023\024\035\024\032\036\027\017\036 )0.5(\024\023\031\b\024\035\017, )]TJ -0.001 Tw T* (\017\002\t\021\024\004\027\024\036 \027\026\035\017\004\017\036 \032\017\ \030\026 \r)Tj /Span<>> BDC ( )Tj EMC (\023\024\007\f\035\017\017\f\021\024\n \f\035\024\036 \f\021\036\027)Tj 0 Tw (-)Tj 0.006 Tw T* (\022\017 \022\017\001\022\017, \027\026\035\017\004\017\036 \235\017\002\ \030\024\026 \023\024\007\f\035\017\017\f\021\024\020\024 \f\035\024\016\ , \031\f\017)Tj 0 Tw (-)Tj 0.419 Tw T* (\035\036\027\027\026\016 \023\036\030\017\f\021\026\035\034\021\017\022\026\ \022\017\001\022\017, \017\027\021\030\026\024\023\036\030\026\006\017\024\ \027\027\t\036 )Tj 0.33 Tw T* (\024\f\035\024\032\027\036\027\017\016, \023\030\024\007\024\035\032\017\ \021\036\035\034\027\024\f\021\034 \220\027\007\024\f\022\024\023\017\004\ \036\f\022\024\020\024 )Tj 0 Tw T* (\r\n\036\001\026\021\036\035\034\f\021\r\026.)Tj 0.007 Tw T* (\025\024\035\017\004\036\f\021\r\036\027\027\t\036 \023\030\017\027\026\ \022\017 \(\030\026\n\036\030 \031\007\026\035\016\036\n\024\020\024 \027\ \024\r\024)Tj 0 Tw (-)Tj 0.283 Tw T* [(\024\002\030\026\024\r\026\027\017\016 )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC 6.885 0 Td [(\023\030\024\007\024\035\032\017\021\036\035\034\027\024\f\021\034 )0.5(\r\n\036\001\026\021\036\035\034\f\021\r\026\) )]TJ -0.023 Tw -6.885 -1.218 Td (\002\t\035\017 \023\030\017\r\036\007\036\027\t \f)Tj /Span<>> BDC ( )Tj EMC (\023\024\n\024\013\034\033 ROC-\026\027\026\035\017\026 \022)Tj /Span<>> BDC ( )Tj EMC (\002\017\027\026\030\027\t\n )Tj 0 Tw T* (\027\026\004\036\027\017\016\n \(\230\026\002\035.)Tj /Span<>> BDC ( )Tj EMC (5\).)Tj 0.115 Tw T* (\210\007\027\024\235\026\022\021\024\030\027\t\005 \030\036\020\030\036\f\ \f\017\024\027\027\t\005 \026\027\026\035\017 \023\024\022\026\026\035\ , \004\021\024 )Tj 0.038 Tw T* (\235\026\022\021\024\030\026\n\017, \f\021\026\021\017\f\021\017\004\036\ \f\022\017 \027\026\004\017\n\024 \031\r\036\035\017\004\017\r\026\033\013\ \017\n\017 )Tj 0.062 Tw T* [(\r\036\030\024\016\021\027\024\f\021\034 )0.6(\022\024\027\r\036\030\f\017\017 )0.5(\r\n\036\001\026\021\036\035\034\f\021\r\026 )0.6(\031)]TJ /Span<>> BDC ( )Tj EMC 17.235 0 Td [(\r\f\036\005 )0.5(\022\024\020\024\030)]TJ 0 Tw (-)Tj -0.022 Tw -17.235 -1.218 Td (\021\t \023\026\006\017\036\027\021\024\r, \002\t\035\017: \027\036\031\007\ \024\002\027\024\036 \030\026\f\023\024\035\024\032\036\027\017\036 \024\ \023\031\b\024)Tj 0 Tw (-)Tj -0.016 Tw T* (\035\017 \(\210\234)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (20,9; 95% \212\222:2,5\226175,6; )Tj /T1_1 1 Tf 0 Tw (\032)Tj /T1_0 1 Tf -0.016 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,02\), \017\027\021\030\026\024\023\036)Tj 0 Tw (-)Tj -0.031 Tw T* (\030\026\006\017\024\027\027\t\036 \024\f\035\024\032\027\036\027\017\016\ \(\210\234)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (26,6; 95% \212\222:2,2\22633,1; )Tj /T1_1 1 Tf 0 Tw T* (\032)Tj /T1_0 1 Tf 0.318 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC 2.079 0 Td [(0,02\), \235\017\002\030\024 )0.5(\023\024\007\f\035\017\017\f\021\024\020\024 )0.5(\f\035\024\016 )0.5(\(\210\234)]TJ /Span<>> BDC ( )Tj EMC 17.796 0 Td (=)Tj /Span<>> BDC ( )Tj EMC (4,9 )Tj 0.437 Tw -19.875 -1.218 Td (95% \212\222:1,2\22620,2; )Tj /T1_1 1 Tf 0 Tw (\032)Tj /T1_0 1 Tf 0.437 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,03\), \026)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\032\036 \031\f\017\035\036\027\027\026\016 )Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0 Tw 9 0 0 9 70.8661 730.483 Tm (\020\004\206\f\t\204\004 3.)Tj 0 0 0 1 k /GS1 gs /T1_1 1 Tf ( \217\031\033\n\t\032\031\030\t\024\027\031\021\021\020\031 \032\031\016\ \205\023\022\024\026\024\020 \n\033\031\032\026\203\025\017 \027)Tj /Span<>> BDC ( )Tj EMC (\202\032\205\033\033\026\004)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0 -1.2 TD [(T)48(able 3.)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf [( Character)-36.9(istics of endoscopic remov)16.3(al of neoplas)33.1(ms)]TJ ET 0 0 0 1 K 0.5 w /GS2 gs q 1 0 0 1 70.8661 715.181 cm 0 0 m 224.187 0 l S Q q 1 0 0 1 71.1161 694.3618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 295.0532 715.181 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 295.0532 694.3618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 371.5886 715.181 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 371.5886 694.3618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 448.124 715.181 cm 0 0 m 76.785 0 l S Q q 1 0 0 1 448.124 694.3618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 524.6594 694.3618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 70.8661 694.1118 cm 0 0 m 224.187 0 l S Q q 1 0 0 1 71.1161 682.9005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 295.0532 694.1118 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 295.0532 682.9005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 371.5886 694.1118 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 371.5886 682.9005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 448.124 694.1118 cm 0 0 m 76.785 0 l S Q q 1 0 0 1 448.124 682.9005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 682.9005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 682.6505 cm 0 0 m 224.187 0 l S Q q 1 0 0 1 71.1161 671.4392 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 295.0532 682.6505 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 295.0532 671.4392 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 371.5886 682.6505 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 371.5886 671.4392 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 448.124 682.6505 cm 0 0 m 76.785 0 l S Q q 1 0 0 1 448.124 671.4392 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 671.4392 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 671.1892 cm 0 0 m 224.187 0 l S Q q 1 0 0 1 71.1161 659.9779 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 295.0532 671.1892 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 295.0532 659.9779 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 371.5886 671.1892 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 371.5886 659.9779 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 448.124 671.1892 cm 0 0 m 76.785 0 l S Q q 1 0 0 1 448.124 659.9779 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 659.9779 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 659.7279 cm 0 0 m 224.187 0 l S Q q 1 0 0 1 71.1161 648.5166 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 295.0532 659.7279 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 295.0532 648.5166 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 371.5886 659.7279 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 371.5886 648.5166 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 448.124 659.7279 cm 0 0 m 76.785 0 l S Q q 1 0 0 1 448.124 648.5166 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 648.5166 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 648.2666 cm 0 0 m 224.187 0 l S Q q 1 0 0 1 71.1161 637.0554 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 295.0532 648.2666 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 295.0532 637.0554 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 371.5886 648.2666 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 371.5886 637.0554 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 448.124 648.2666 cm 0 0 m 76.785 0 l S Q q 1 0 0 1 448.124 637.0554 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 637.0554 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 636.8054 cm 0 0 m 224.187 0 l S Q q 1 0 0 1 71.1161 625.5941 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 295.0532 636.8054 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 295.0532 625.5941 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 371.5886 636.8054 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 371.5886 625.5941 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 448.124 636.8054 cm 0 0 m 76.785 0 l S Q q 1 0 0 1 448.124 625.5941 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 625.5941 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 625.3441 cm 0 0 m 224.187 0 l S Q q 1 0 0 1 71.1161 614.1328 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 295.0532 625.3441 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 295.0532 614.1328 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 371.5886 625.3441 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 371.5886 614.1328 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 448.124 625.3441 cm 0 0 m 76.785 0 l S Q q 1 0 0 1 448.124 614.1328 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 614.1328 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 613.8828 cm 0 0 m 224.187 0 l S Q q 1 0 0 1 71.1161 602.6715 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 295.0532 613.8828 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 295.0532 602.6715 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 371.5886 613.8828 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 371.5886 602.6715 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 448.124 613.8828 cm 0 0 m 76.785 0 l S Q q 1 0 0 1 448.124 602.6715 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 602.6715 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 602.4215 cm 0 0 m 224.187 0 l S Q q 1 0 0 1 295.0532 602.4215 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 371.5886 602.4215 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 448.124 602.4215 cm 0 0 m 76.785 0 l S Q BT /GS1 gs /T1_2 1 Tf 8 0 0 8 166.3449 701.7464 Tm (\200\004\006\004\214\r\003\006)Tj 19.556 0.6 Td (C-EMR)Tj -0.453 -1.2 Td (\()Tj /T1_3 1 Tf (n)Tj /T1_2 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (52\))Tj 10.546 1.2 Td (ESD)Tj -0.979 -1.2 Td (\()Tj /T1_3 1 Tf (n)Tj /T1_2 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (51\))Tj /T1_3 1 Tf 11.077 0.6 Td (p)Tj /T1_0 1 Tf -51.296 -2.033 Td (\204\036\007\017\026\027\026 \r\030\036\n\036\027\017 \024\023\036\030\026\ \006\017\017 \(\022\r\026\030\021\017\035\017\), \n\017\027.)Tj 30.157 0 Td (30)Tj /Span<>> BDC ( )Tj EMC (\(25\22639\))Tj 9.567 0 Td (60)Tj /Span<>> BDC ( )Tj EMC (\(60\22675\))Tj 10.239 0 Td (0,001**)Tj -49.963 -1.433 Td (\223\026\f\021\024\021\026 \017\027\021\030\026\024\023\036\030\026\006\017\ \024\027\027\t\b \024\f\035\024\032\027\036\027\017\005, )Tj /T1_1 1 Tf (n)Tj /T1_0 1 Tf ( \(%\))Tj 30.713 0 Td (3)Tj /Span<>> BDC ( )Tj EMC (\(5,8%\))Tj 11.025 0 Td (0)Tj 8.974 0 Td (0,3*)Tj -50.713 -1.433 Td (\025\030\024\r\024\021\036\004\036\027\017\036, )Tj /T1_1 1 Tf (n)Tj /T1_0 1 Tf ( \(%\))Tj 30.713 0 Td (2)Tj /Span<>> BDC ( )Tj EMC (\(3,8%\))Tj 11.025 0 Td (0)Tj 8.974 0 Td (0,5*)Tj -50.713 -1.433 Td (\215\036\030\235\024\030\026\006\017\016, )Tj /T1_1 1 Tf (n)Tj /T1_0 1 Tf ( \(%\))Tj 30.713 0 Td (1)Tj /Span<>> BDC ( )Tj EMC (\(1,9%\))Tj 11.025 0 Td (0)Tj 8.974 0 Td (1,0*)Tj -50.713 -1.433 Td (\223\026\f\021\024\021\026 \023\024\f\035\036\024\023\036\030\026\006\017\ \024\027\027\t\b \024\f\035\024\032\027\036\027\017\005)Tj 30.213 0 Td (10)Tj /Span<>> BDC ( )Tj EMC (\(19,2%\))Tj 9.567 0 Td (12)Tj /Span<>> BDC ( )Tj EMC (\(23,5%\))Tj 10.433 0 Td (0,6***)Tj -50.213 -1.433 Td (\215\024\f\021\022\024\026\020\031\035\016\006\017\024\027\027\t\005 \f\017\ \027\007\030\024\n, )Tj /T1_1 1 Tf (n)Tj /T1_0 1 Tf ( \(%\))Tj 30.463 0 Td (9)Tj /Span<>> BDC ( )Tj EMC (\(17,3%\))Tj 9.317 0 Td (11)Tj /Span<>> BDC ( )Tj EMC (\(21,6%\))Tj 10.933 0 Td (0,6*)Tj -50.713 -1.433 Td (\025\030\024\r\024\021\036\004\036\027\017\036, )Tj /T1_1 1 Tf (n)Tj /T1_0 1 Tf ( \(%\))Tj 32.171 0 Td (0)Tj 8.108 0 Td (2)Tj /Span<>> BDC ( )Tj EMC (\(3,9%\))Tj 10.433 0 Td (0,3*)Tj -50.713 -1.433 Td (\215\036\030\235\024\030\026\006\017\016, )Tj /T1_1 1 Tf (n)Tj /T1_0 1 Tf ( \(%\))Tj 30.713 0 Td (1)Tj /Span<>> BDC ( )Tj EMC (\(1,9%\))Tj 11.025 0 Td (0)Tj 8.974 0 Td (1,0*)Tj /T1_1 1 Tf 7 0 0 7 70.8662 590.9369 Tm (\032\025\003\031\006\026\021\025\031: \032*)Tj /Span<>> BDC ( )Tj EMC (\227 \024\n\006\021\020\017 \013\032\025\024\031\032\025\017 \225\025\001\ \031\032\026; \032**)Tj /Span<>> BDC ( )Tj EMC [(\227 \013\032\025\024\031\032\025\017 \240\026\021\021\026\226\214)50.5(\025\024\021\025; \032***)]TJ /Span<>> BDC ( )Tj EMC (\227 \013\032\025\024\031\032\025\017 \232)Tj 4.081 0 0 4.081 360.3606 593.2679 Tm (2)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 9 0 0 9 70.8662 571.633 Tm (\020\004\206\f\t\204\004 4.)Tj 0 0 0 1 k /GS1 gs /T1_1 1 Tf ( \220\032\205\030\021\n\t\024\025, \027\n\016\021\025\013\001\025\031 \027\ )Tj /Span<>> BDC ( )Tj EMC [(\004\n\030\031 \r\021\030\n\t\013\n\033\025\006\031\t\013\n\202\n \027\003\ \031\001\026\024\031)0.5(\023\022\t\024\027\026)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf T* [(T)48(able 4.)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf [( Dif\233culties dur)-36.8(ing endoscopic operation)]TJ ET /GS2 gs q 1 0 0 1 70.8662 556.331 cm 0 0 m 275.211 0 l S Q q 1 0 0 1 71.1162 535.5118 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 346.0768 556.331 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 346.0768 535.5118 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 405.6044 556.331 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 405.6044 535.5118 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 465.1319 556.331 cm 0 0 m 59.778 0 l S Q q 1 0 0 1 465.1319 535.5118 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 524.6595 535.5118 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 70.8662 535.2618 cm 0 0 m 275.211 0 l S Q q 1 0 0 1 71.1162 524.0505 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 346.0768 535.2618 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 346.0768 524.0505 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 405.6044 535.2618 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 405.6044 524.0505 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 465.1319 535.2618 cm 0 0 m 59.778 0 l S Q q 1 0 0 1 465.1319 524.0505 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6595 524.0505 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8662 523.8005 cm 0 0 m 275.211 0 l S Q q 1 0 0 1 71.1162 512.5892 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 346.0768 523.8005 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 346.0768 512.5892 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 405.6044 523.8005 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 405.6044 512.5892 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 465.1319 523.8005 cm 0 0 m 59.778 0 l S Q q 1 0 0 1 465.1319 512.5892 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6595 512.5892 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8662 512.3392 cm 0 0 m 275.211 0 l S Q q 1 0 0 1 71.1162 501.1279 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 346.0768 512.3392 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 346.0768 501.1279 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 405.6044 512.3392 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 405.6044 501.1279 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 465.1319 512.3392 cm 0 0 m 59.778 0 l S Q q 1 0 0 1 465.1319 501.1279 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6595 501.1279 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8662 500.8779 cm 0 0 m 275.211 0 l S Q q 1 0 0 1 71.1162 489.6666 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 346.0768 500.8779 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 346.0768 489.6666 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 405.6044 500.8779 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 405.6044 489.6666 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 465.1319 500.8779 cm 0 0 m 59.778 0 l S Q q 1 0 0 1 465.1319 489.6666 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6595 489.6666 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8662 489.4166 cm 0 0 m 275.211 0 l S Q q 1 0 0 1 71.1162 478.2054 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 346.0768 489.4166 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 346.0768 478.2054 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 405.6044 489.4166 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 405.6044 478.2054 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 465.1319 489.4166 cm 0 0 m 59.778 0 l S Q q 1 0 0 1 465.1319 478.2054 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6595 478.2054 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8662 477.9554 cm 0 0 m 275.211 0 l S Q q 1 0 0 1 346.0768 477.9554 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 405.6044 477.9554 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 465.1319 477.9554 cm 0 0 m 59.778 0 l S Q BT /GS1 gs /T1_2 1 Tf 8 0 0 8 191.8568 542.8964 Tm (\200\004\006\004\214\r\003\006)Tj 21.682 0.6 Td (C-EMR)Tj -0.453 -1.2 Td (\()Tj /T1_3 1 Tf (n)Tj /T1_2 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (52\))Tj 8.42 1.2 Td (ESD)Tj -0.979 -1.2 Td (\()Tj /T1_3 1 Tf (n)Tj /T1_2 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (51\))Tj /T1_3 1 Tf 8.951 0.6 Td (p)Tj /T1_0 1 Tf -52.359 -2.033 Td (\203\036\031\007\024\002\027\024\036 \007\035\016 \220\027\007\024\f\022\ \024\023\017\004\036\f\022\024\020\024 \r\n\036\001\026\021\036\035\034\f\ \021\r\026 \030\026\f\023\024\035\024\032\036\027\017\036 \024\023\031\b\ \024\035\017, )Tj /T1_1 1 Tf (n)Tj /T1_0 1 Tf ( \(%\))Tj 35.528 0 Td (20)Tj /Span<>> BDC ( )Tj EMC (\(38,5%\))Tj 7.441 0 Td (15)Tj /Span<>> BDC ( )Tj EMC (\(29,4%\))Tj 8.307 0 Td (0,3***)Tj -51.276 -1.433 Td (\025\030\031\023\027\t\036 \f\024\f\031\007\t \023\024\007\f\035\017\017\ \f\021\024\020\024 \f\035\024\016, )Tj /T1_1 1 Tf (n)Tj /T1_0 1 Tf ( \(%\))Tj 36.028 0 Td (5)Tj /Span<>> BDC ( )Tj EMC (\(9,6%\))Tj 6.941 0 Td (10)Tj /Span<>> BDC ( )Tj EMC (\(19,6%\))Tj 8.807 0 Td (0,2*)Tj -51.776 -1.433 Td (\222\002\t\021\024\004\027\024\036 \027\026\035\017\004\017\036 \032\017\ \030\026 \r)Tj /Span<>> BDC ( )Tj EMC (\023\024\007\f\035\017\017\f\021\024\n \f\035\024\036, )Tj /T1_1 1 Tf (n)Tj /T1_0 1 Tf ( \(%\))Tj 35.778 0 Td (6)Tj /Span<>> BDC ( )Tj EMC (\(11,5%\))Tj 7.191 0 Td (15)Tj /Span<>> BDC ( )Tj EMC (\(29,4%\))Tj 8.057 0 Td (0,03***)Tj -51.026 -1.433 Td (\205\017\002\030\024 \023\024\007\f\035\017\017\f\021\024\020\024 \f\035\ \024\016, )Tj /T1_1 1 Tf (n)Tj /T1_0 1 Tf ( \(%\))Tj 36.028 0 Td (3)Tj /Span<>> BDC ( )Tj EMC (\(5,8%\))Tj 6.941 0 Td (21)Tj /Span<>> BDC ( )Tj EMC (\(41,2%\))Tj 7.807 0 Td (0,001***)Tj -50.776 -1.433 Td (\211\f\017\035\036\027\027\026\016 \023\036\030\017\f\021\026\035\034\021\ \017\022\026 \022\017\001\022\017, )Tj /T1_1 1 Tf (n)Tj /T1_0 1 Tf ( \(%\))Tj 35.528 0 Td (15)Tj /Span<>> BDC ( )Tj EMC (\(28,8%\))Tj 7.691 0 Td (9)Tj /Span<>> BDC ( )Tj EMC (\(17,6%\))Tj 8.557 0 Td (0,2*)Tj /T1_1 1 Tf 7 0 0 7 70.8662 466.4707 Tm (\032\025\003\031\006\026\021\025\031: \032*)Tj /Span<>> BDC ( )Tj EMC (\227 \024\n\006\021\020\017 \013\032\025\024\031\032\025\017 \225\025\001\ \031\032\026; \032**)Tj /Span<>> BDC ( )Tj EMC [(\227 \013\032\025\024\031\032\025\017 \240\026\021\021\026\226\214)50.5(\025\024\021\025; \032***)]TJ /Span<>> BDC ( )Tj EMC (\227 \013\032\025\024\031\032\025\017 \232)Tj 4.081 0 0 4.081 360.3606 468.8017 Tm (2)Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\033\030\031\030\213\b)-20.9(\035\231\213\233\t \021\032)50(\b)42(\032\231\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj -51.938 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 23, \023\0221)69(, 202)69(4)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 23, \023\0221)69(, 202)69(4)]TJ /T1_5 1 Tf 25 0 0 25 28.115 56.0378 Tm (26)Tj ET endstream endobj 14 0 obj <> endobj 15 0 obj <> endobj 16 0 obj <> endobj 17 0 obj <> endobj 18 0 obj <> endobj 2468 0 obj <>/ExtGState<>/Font<>/ProcSet[/PDF/Text]/Properties<>/Shading<>/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 2469 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 2470 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 2471 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 2472 0 obj <>/Font<>/ProcSet[/PDF/Text/ImageB]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 2479 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\235\001\201\025\006\n)10(\025\221\220\017\016\006\n\013\205 \024\215\n)10(\025)21(\222)21(\232\n)-9.9(\026)11(\025\024\220\205 \006\022\227\220\002\n\215\007\205\002\001\020\024 \002\ \013\222\002\016\222\025\024 )]TJ 0 -1 TD [(\006)-10(\007\220\222\220\006)-9.9(\026)11(\025\203 \025\f\025\007\025\017\n\220 \r\022\007\016\017\016\001\220\220\ \025\221\215)21.1(\207\025\007\016\203 \025\f\025\201\025\017\001\025\203 \n\220\n\220. )]TJ T* [(\033\016\222)21(\215\007\216)21(\026)11(\013\026\020 \002\013\001\201\025\024\220\222\220\002\025\r\013\001\001\025\ \202)10(\025 \220\006\006)-10(\007\016\201\025\r\013\001\220\205.)]TJ 34.507 2 Td [(Endoscopic mucosal r)31(esection with a cir)31(cumfer)31.1(ential incision in th)11(e )]TJ 2.851 -1 Td [(r)31(emov)10(al of colon neoplasms. Results of a r)21(andomiz)10.1(ed trial.)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf -0.034 Tw 10 0 0 10 42.5197 724.8299 Tm [(Micr)-32(osof)-27.9(t O)-32(f\237ce E)35(x)-13(cel 2018. \221\021\026\021\017\f\021\017\004\036\f\022\026\016 \024\002\030\ \026\002\024\021\022\026 )]TJ 0.207 Tw 0 -1.218 TD (\030\036\031\035\034\021\026\021\024\r \017\f\f\035\036\007\024\r\026\027\ \017\016 \023\030\024\r\024\007\017\035\026\f\034 \f)Tj /Span<>> BDC ( )Tj EMC (\023\030\017\n\036\027\036)Tj 0 Tw (-)Tj 0.092 Tw T* [(\027\017\036\n )0.5(\023\030\024\020\030\026\n\n\027\024\020\024 )0.6(\024\002\036\f\023\036\004\036\027\017\016 )0.5(IBM )0.6(SPS)17(S )0.5(S)15(t)15(a)15(t)-32(ist)-32(ics )]TJ 0 Tw T* (v.)Tj /Span<>> BDC ( )Tj EMC (26.)Tj 0.576 Tw T* (\202\027\026\035\017 \030\036\031\035\034\021\026\021\024\r \017\f\f\035\ \036\007\024\r\026\027\017\016 \023\030\024\r\036\007\036\027 \f\024)Tj 0 Tw (-)Tj 0.302 Tw T* [(\020\035\026\f\027\024 )0.5(\023\030\024\021\024\022\024\035\031 )0.6(\253intent)-32(ion )0.5(t)17(o )0.6(tr)-24(ea)15(t\273. )0.5(\204\026\021\036\030\017\026\035\t )]TJ 0.468 Tw 0 -1.218 TD (\017\f\f\035\036\007\024\r\026\027\017\016 \002\t\035\017 \023\024\007\r\ \036\030\020\027\031\021\t \f\021\026\021\017\f\021\017\004\036\f\022\024\ \n\031 )Tj 0.094 Tw 0 -1.218 TD (\026\027\026\035\017\031 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\023\024\n\024\013\017 \023\026\030\026\n\036\021\030\017\004\036\f\022\024\ \020\024 \017)Tj /Span<>> BDC ( )Tj EMC (\027\036\023\026\030\026\n\036)Tj 0 Tw (-)Tj 0.143 Tw T* (\021\030\017\004\036\f\022\024\020\024 \n\036\021\024\007\024\r. \215\030\ \017)Tj /Span<>> BDC ( )Tj EMC (\024\023\017\f\026\027\017\017 \022\024\035\017\004\036\f\021\r\036\027\027\ \t\b )Tj 0.279 Tw T* (\023\024\022\026\026\021\036\035\036\005, \017\n\036\033\013\017\b \027\ \024\030\n\026\035\034\027\024\036 \030\026\f\023\030\036\007\036\035\036\ \027\017\036, )Tj 0.201 Tw T* (\023\024\035\031\004\036\027\027\t\036 \007\026\027\027\t\036 \024\002\255\ \036\007\017\027\016\035\017\f\034 \r)Tj /Span<>> BDC ( )Tj EMC (\r\026\030\017\026\006\017\024\027\027\t\036 )Tj 0.365 Tw T* (\030\016\007\t, \r)Tj /Span<>> BDC ( )Tj EMC (\022\024\021\024\030\t\b \023\030\024\r\024\007\017\035\f\016 \030\026\f\ \004\036\021 \f\030\036\007\027\017\b \(M\) )Tj 0.214 Tw 0 -1.218 TD (\017)Tj /Span<>> BDC ( )Tj EMC (\f\021\026\027\007\026\030\021\027\t\b \024\021\022\035\024\027\036\027\017\ \005 \(\261)Tj /Span<>> BDC ( )Tj EMC (SD\), \020\030\026\027\017\006 95% \007\024)Tj 0 Tw (-)Tj 0.113 Tw 0 -1.218 TD (\r\036\030\017\021\036\035\034\027\024\020\024 \017\027\021\036\030\r\026\ \035\026 \(95% \212\222\). \025\024\035\017\004\036\f\021\r\036\027\027\t\ \036 )Tj 0.281 Tw 0 -1.218 TD (\023\024\022\026\026\021\036\035\017, \030\026\f\023\030\036\007\036\035\ \036\027\017\036 \022\024\021\024\030\t\b \024\021\035\017\004\026\035\024\ \f\034 \024\021 )Tj 0.4 Tw T* [(\027\024\030\n\026\035\034\027\024\020\024, \024\023\017\f\t\r\026\035\017\ \f\034 )0.5(\023\030\017)]TJ /Span<>> BDC ( )Tj EMC [(\023\024\n\024\013\017 )0.5(\027\026\004\036\027\017\005 )]TJ 0.022 Tw T* [(\n\036\007\017\026\027\t )0.5(\(Me\) )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC 6.796 0 Td [(\017\027\021\036\030\022\r\026\030\021\017\035\034\027\024\020\024 )0.5(\030\026\n\026\b\026 )0.6(\(Q1-Q3\). )]TJ 0.091 Tw -6.796 -1.218 Td (\215\030\017)Tj /Span<>> BDC ( )Tj EMC 1.944 0 Td [(\f\030\026\r\027\036\027\017\017 )0.6(\027\026\004\036\027\017\005 )0.6(\r)]TJ /Span<>> BDC ( )Tj EMC [(\027\024\030\n\026\035\034\027\024 )0.5(\030\026\f\023\030\036\007\036\035\036\027)]TJ 0 Tw (-)Tj 0.475 Tw -1.944 -1.218 Td (\027\t\b \f\024\r\024\022\031\023\027\024\f\021\016\b \022\024\035\017\004\ \036\f\021\r\036\027\027\t\b \007\026\027\027\t\b \023\030\017)Tj 0 Tw (-)Tj 0.222 Tw T* (\n\036\027\016\035\f\016 t-\022\030\017\021\036\030\017\005 \221\021\034\ \033\007\036\027\021\026. \212\035\016 \f\030\026\r\027\036\027\017\016 \ \n\036)Tj 0 Tw (-)Tj 0.177 Tw T* (\007\017\026\027 \017\f\023\024\035\034\024\r\026\035\f\016 \021\036\f\021\ U-\022\030\017\021\036\030\017\005 \204\026\027\027\026\226\211\017\021\ \027\017. )Tj 0.016 Tw T* (\215\030\017)Tj /Span<>> BDC ( )Tj EMC (\026\027\026\035\017\036 \022\026\004\036\f\021\r\036\027\027\t\b \023\036\ \030\036\n\036\027\027\t\b \023\030\017\n\036\027\016\035\017\f\034 )Tj 0.048 Tw T* (\022\030\017\021\036\030\017\005 \233)Tj 0 Tw 5.83 0 0 5.83 89.4792 460.2438 Tm (2)Tj 0.048 Tw 10 0 0 10 92.3942 456.9138 Tm ( \017)Tj /Span<>> BDC ( )Tj EMC (\021\024\004\027\t\005 \022\030\017\021\036\030\017\005 \205\017\001\036\ \030\026. \212\035\016 \024\006\036\027\022\017 )Tj 0.159 Tw -4.987 -1.218 Td (\235\026\022\021\024\030\024\r \030\017\f\022\026 \030\026\f\f\004\017\021\ \t\r\026\035\017\f\034 \024\021\027\024\001\036\027\017\016 \001\026\027\ \f\024\r )Tj 0.051 Tw T* [(\(\210\234\) )0.5(\023\030\017)]TJ /Span<>> BDC ( )Tj EMC 4.2 0 Td [(\023\024\n\024\013\017 )0.5(\004\036\021\t\030\036\b\023\024\035\034\027\t\b )0.5(\021\026\002\035\017\006 )0.6(\f)]TJ /Span<>> BDC ( )Tj EMC 14.521 0 Td [(95% )0.5(\007\024)]TJ 0 Tw (-)Tj 0.153 Tw -18.721 -1.218 Td [(\r\036\030\017\021\036\035\034\027\t\n \017\027\021\036\030\r\026\035\024\ \n )0.5(\(\212\222\). \200\t\016\r\035\036\027\017\036 \r\024\n\024\032)]TJ 0 Tw (-)Tj 0.035 Tw T* (\027\t\b \235\026\022\021\024\030\024\r \030\017\f\022\026 \023\030\024\r\ \036\007\036\027\027\024\020\024 \035\036\004\036\027\017\016 \024\f\031\ \013\036\f\021)Tj 0 Tw (-)Tj 0.147 Tw T* (\r\035\016\035\024\f\034 \f)Tj /Span<>> BDC ( )Tj EMC [(\017\f\023\024\035\034\024\r\026\027\017\036\n )0.5(\002\017\027\026\030\027\024\005 \035\024\020\017\f\021\017\004\036\f\022\ \024\005 )]TJ 0 Tw T* (\030\036\020\030\036\f\f\017\017.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 42.5896 347.3118 Tm [(\033\034\020)21(\223)50(\r\241)46(\024)52(\026)45(\024\232)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0 Tc 0.016 Tw 10 0 0 10 42.5197 322.9558 Tm (\217\036\031\035\034\021\026\021\t \035\036\004\036\027\017\016 \023\030\ \024\026\027\026\035\017\017\030\024\r\026\027\t \031)Tj /Span<>> BDC ( )Tj EMC (52 \002\024\035\034\027\t\b )Tj 0.329 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC [(\027\024\r\024\024\002\030\026\024\r\026\027\017\016\n\017 )0.5(\024\002\024\007\024\004\027\024\005 \022\017\001\022\017, \023\036\030\036\ \027\036\f)]TJ 0 Tw (-)Tj 0.015 Tw T* (\001\017\b \220\027\007\024\f\022\024\023\017\004\036\f\022\031\033 \030\ \036\036\022\006\017\033 \f\035\017\017\f\021\024\005 \024\002\024\035\ \024\004\022\017 )Tj 0.014 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\031)Tj /Span<>> BDC ( )Tj EMC (51 \023\026\006\017\036\027\021\026, \022\024\021\024\030\t\n \002\t\035\ \026 \r\t\023\024\035\027\036\027\026 \007\017\f\f\036\022\006\017\016 )Tj 0 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\023\024\007\f\035\017\017\f\021\024\n \f\035\024\036.)Tj 0.18 Tw T* [(\204\036\007\017\026\027\026 )0.5(\r\030\036\n\036\027\017 )0.6(\r\t\023\024\035\027\036\027\017\016 )0.5(C-EMR )0.6(\023\030\017)]TJ /Span<>> BDC ( )Tj EMC 18.218 0 Td (\031\007\026\035\036\027\017\017 )Tj 0.431 Tw -18.218 -1.218 Td [(\220\023\017\021\036\035\017\026\035\034\027\t\b )0.6(\027\024\r\024\024\002\030\026\024\r\026\027\017\005 )0.5(\024\002\024\007\024\004\027\024\005 )0.5(\022\017\001)]TJ 0 Tw (-)Tj 0.182 Tw T* (\022\017 \f\024\f\021\026\r\017\035\026 30 \(25\22639\), \023\030\024\021\ \017\r 60 \(60\22675\) \n\017\027\031\021 )Tj 0.201 Tw 23.244 48.712 Td (\r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 ESD. \217\026\035\017\004\017\016 \r)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\007\024\035\032\017\021\036\035\034\027\024\f\021\017 \r\n\036\ )Tj 0 Tw (-)Tj 0.683 Tw 0 -1.218 TD [(\001\026\021\036\035\034\f\021\r\026 )0.6(\024\022\026\026\035\017\f\034 )0.5(\f\021\026\021\017\f\021\017\004\036\f\022\017 )0.6(\027\026\004\017\n\t\n\017 )]TJ 0 Tw 0 -1.218 TD (\()Tj /T1_3 1 Tf (p)Tj /T1_1 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,001\) \(\230\026\002\035.)Tj /Span<>> BDC ( )Tj EMC (3\).)Tj 0.123 Tw 0 -1.218 TD (\222\027\021\030\026\024\023\036\030\026\006\017\024\027\027\024\036 \022\ \030\024\r\024\021\036\004\036\027\017\036 \030\026\r\017\035\024\f\034\ \031)Tj /Span<>> BDC ( )Tj EMC (\007\r\031\b )Tj 0.046 Tw 0 -1.218 TD [(\002\024\035\034\027\t\b )0.6(2/52 )0.6(\(3,8%\) )0.6(\r)]TJ /Span<>> BDC ( )Tj EMC 9.707 0 Td [(\020\030\031\023\023\036 )0.6(C-EMR. )0.6(\211)]TJ /Span<>> BDC ( )Tj EMC 6.907 0 Td [(\024\007\027\024\020\024 )0.6(\023\026\006\017)]TJ 0 Tw (-)Tj -0.007 Tw -16.614 -1.218 Td (\036\027\021\026 \r)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\006\036\f\f\036 \031\007\026\035\036\027\017\016 \024\023\031\ \b\024\035\017 \f\017\020\n\024\r\017\007\027\024\005 \022\017\001)Tj 0 Tw (-)Tj 0.189 Tw T* (\022\017 \030\026\n\036\030\024\n 30 \n\n \027\026)Tj /Span<>> BDC ( )Tj EMC [(\235\024\027\036 \031\f\017\035\036\027\027\024\005 )0.5(\023\036\030\017\f\021\026\035\034)]TJ 0 Tw (-)Tj 0.23 Tw 0 -1.218 TD (\021\017\022\017 \022\017\001\022\017 \017)Tj /Span<>> BDC ( )Tj EMC (\002\030\033\001\027\024\020\024 \021\017\023\026 \007\t\b\026\027\017\016\ \027\036 \031\007\026\035\024\f\034 )Tj 0.213 Tw T* (\220\027\007\024\f\022\024\023\017\004\036\f\022\017 \022\031\023\017\030\ \024\r\026\021\034 \022\030\024\r\024\021\036\004\036\027\017\036 \017)Tj /Span<>> BDC ( )Tj EMC (\022\030\031\023)Tj 0 Tw (-)Tj 0.244 Tw T* (\027\t\b \f\024\f\031\007\024\r \023\024\007\f\035\017\017\f\021\024\020\ \024 \f\035\024\016. \207\t\035\026 \r\t\023\024\035\027\036\027\026 )Tj 0.236 Tw T* (\022\024\027\r\036\030\f\017\016 \r)Tj /Span<>> BDC ( )Tj EMC (\024\023\036\030\026\021\017\r\027\024\036 \r\n\036\001\026\021\036\035\034\ \f\021\r\024 \r)Tj /Span<>> BDC ( )Tj EMC (\024\002\255\036\n\036 )Tj 0.066 Tw T* (\030\036\036\022\006\017\017 \f\017\020\n\024\r\017\007\027\024\005 \022\ \017\001\022\017. \200\024 \r\021\024\030\024\n \f\035\031\004\026\036 \017\ \027)Tj 0 Tw (-)Tj 0.362 Tw T* (\021\030\026\024\023\036\030\026\006\017\024\027\027\024\036 \022\030\024\ \r\024\021\036\004\036\027\017\036 \002\t\035\024 \024\f\021\026\027\024\ \r\035\036\027\024 )Tj 0.185 Tw T* (\220\027\007\024\f\022\024\023\017\004\036\f\022\017 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\023\024\n\024\013\017 \020\036\n\024\f\021\026\021\017\004\036\f\022\017\ \b \013\017\023)Tj 0 Tw (-)Tj 0.125 Tw T* (\006\024\r. \222\027\021\030\026\024\023\036\030\026\006\017\024\027\027\ \026\016 \023\036\030\235\024\030\026\006\017\016 \f\021\036\027\022\017\ \022\017\001\022\017 )Tj 0.233 Tw T* (\r\024\027\017\022\035\026 \031)Tj /Span<>> BDC ( )Tj EMC (\024\007\027\024\020\024 \023\026\006\017\036\027\021\026 1/52 \(1,9%\) \ \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 )Tj 0.294 Tw T* (C-EMR \r)Tj /Span<>> BDC ( )Tj EMC (\b\024\007\036 \031\007\026\035\036\027\017\016 \024\023\031\b\024\035\017\ \r\024\f\b\024\007\016\013\036\005 \024\002\024)Tj 0 Tw (-)Tj 0.032 Tw T* (\007\024\004\027\024\005 \022\017\001\022\017 \030\026\n\036\030\024\n \ 30 \n\n \r)Tj /Span<>> BDC ( )Tj EMC (\007\017\026\n\036\021\030\036. \210\027\026 \002\t\035\026 )Tj 0.165 Tw T* (\035\017\022\r\017\007\017\030\024\r\026\027\026 \r)Tj /Span<>> BDC ( )Tj EMC (\b\024\007\036 \024\023\036\030\026\006\017\017 \f)Tj /Span<>> BDC ( )Tj EMC (\023\024\n\024\013\034\033 \f\r\036\007\036)Tj 0 Tw (-)Tj 0.466 Tw T* [(\027\017\016 \022\030\026\036\r \007\036\235\036\022\021\026 \220\027\007\ \024\f\022\024\023\017\004\036\f\022\017\n\017 )0.5(\022\035\017\023\f\026\n\017. )]TJ 0.376 Tw T* [(\215\024\f\035\036\024\023\036\030\026\006\017\024\027\027\t\005 )0.5(\023\036\030\017\024\007 \023\030\024\021\036\022\026\035 \020\035\026\007\ \022\024, )0.5(\002\036 )]TJ 0.115 Tw T* (\024\f\035\024\032\027\036\027\017\005. \203\026)Tj /Span<>> BDC ( )Tj EMC (5 \f\031\021\022\017 \023\024\f\035\036 \r\n\036\001\026\021\036\035\034\ \f\021\r\026 \002\024\035\034)Tj 0 Tw (-)Tj 0.196 Tw T* (\027\024\005 \r)Tj /Span<>> BDC ( )Tj EMC (\031\007\024\r\035\036\021\r\024\030\017\021\036\035\034\027\024\n \f\024\ \f\021\024\016\027\017\017 \002\t\035 \r\t\023\017\f\026\027 )Tj 0.346 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\f\021\026\006\017\024\027\026\030\026. \221\021\026\021\017\f\021\017\004\ \036\f\022\017 \027\026\004\017\n\t\b \030\026\035\017\004\017\005 )Tj 0.234 Tw T* (\023\024)Tj /Span<>> BDC ( )Tj EMC [(\004\026\f\021\024\021\036 \017\027\021\030\026\024\023\036\030\026\006\017\ \024\027\027\t\b )0.5(\024\f\035\024\032\027\036\027\017\005 \n\036\032\007\031 )]TJ 0.002 Tw T* (\024\f\027\024\r\027\024\005 \017)Tj /Span<>> BDC ( )Tj EMC (\022\024\027\021\030\024\035\034\027\024\005 \020\030\031\023\023\026\n\017\ \r\t\016\r\035\036\027\024 \027\036 \002\t\035\024 )Tj 0 Tw T* (\()Tj /T1_3 1 Tf (p)Tj /T1_1 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,3\).)Tj 0.489 Tw T* (\200 \023\024\f\035\036\024\023\036\030\026\006\017\024\027\027\024\n \023\ \036\030\017\024\007\036 \024\f\035\024\032\027\036\027\017\016 \030\026\ )Tj 0 Tw (-)Tj 0.416 Tw T* (\r\017\035\017\f\034 \031)Tj /Span<>> BDC ( )Tj EMC (10)Tj /Span<>> BDC ( )Tj EMC (\(19,2%\) \023\026\006\017\036\027\021\024\r \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 C-EMR )Tj 0.177 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\031)Tj /Span<>> BDC ( )Tj EMC (12)Tj /Span<>> BDC ( )Tj EMC (\(23,5%\) \002\024\035\034\027\t\b)Tj /Span<>> BDC ( )Tj EMC (\227 \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 ESD \()Tj /T1_3 1 Tf 0 Tw (p)Tj /T1_1 1 Tf 0.177 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,6\). )Tj 0.102 Tw T* [(\203\026\017\002\024\035\036\036 )0.6(\004\026\f\021\t\n )0.5(\023\024\f\035\036\024\023\036\030\026\006\017\024\027\027\t\n )0.6(\024\f\035\024\032\027\036\027\017\036\n )]TJ 0.193 Tw T* (\002\t\035 \023\024\f\021\022\024\026\020\031\035\016\006\017\024\027\027\ \t\005 \f\017\027\007\030\024\n \(\215\221\), \r\024\027\017\022\001\017\ \005 )Tj 0.021 Tw T* (\031)Tj /Span<>> BDC ( )Tj EMC (9)Tj /Span<>> BDC ( )Tj EMC (\(17,3%\) \017)Tj /Span<>> BDC ( )Tj EMC (11)Tj /Span<>> BDC ( )Tj EMC (\(21,6%\) \023\026\006\017\036\027\021\024\r \024\f\027\024\r\027\024\005\ \017)Tj /Span<>> BDC ( )Tj EMC (\022\024\027\021)Tj 0 Tw (-)Tj T* (\030\024\035\034\027\024\005 \020\030\031\023\023\t, \f\024\024\021\r\036\ \021\f\021\r\036\027\027\024 \()Tj /T1_3 1 Tf (p)Tj /T1_1 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,6\).)Tj 0.303 Tw T* (\215\024\f\035\036 \r\t\023\024\035\027\036\027\017\016 C-EMR \031)Tj /Span<>> BDC ( )Tj EMC (1/52 \(1,9%\) \002\024\035\034\027\024\020\024 )Tj 0.074 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\023\024\f\035\036\024\023\036\030\026\006\017\024\027\027\024\n \023\036\ \030\017\024\007\036 \027\026)Tj /Span<>> BDC ( )Tj EMC (3 \f\031\021\022\017 \030\026\r\017\035\026\f\034 )Tj 0.364 Tw T* (\023\036\030\235\024\030\026\006\017\016 \022\017\001\036\004\027\024\005\ \f\021\036\027\022\017 \r)Tj /Span<>> BDC ( )Tj EMC (\024\027\036 \r\n\036\001\026\021\036\035\034)Tj 0 Tw (-)Tj 0.215 Tw T* (\f\021\r\026. \212\026\027\027\024\036 \024\f\035\024\032\027\036\027\017\ \036 \023\024\021\030\036\002\024\r\026\035\024 \023\030\024\r\036\007\036\ \027\017\016 )Tj 0.246 Tw T* [(\220\022\f\021\030\036\027\027\024\005 \024\023\036\030\026\006\017\017.\ )0.5(\211\004\017\021\t\r\026\016 \035\024\022\026\035\017\026\006\017\033 \023\ \036\030)]TJ 0 Tw (-)Tj 0.277 Tw T* (\235\024\030\026\021\017\r\027\024\020\024 \024\021\r\036\030\f\021\017\016\ , \023\026\006\017\036\027\021\031 \002\t\035\026 \r\t\023\024\035\027\036\ \027\026 )Tj 0.26 Tw T* [(\023\030\026\r\024\f\021\024\030\024\027\027\016\016 )0.6(\020\036\n\017\022\024\035\220\022\021\024\n\017\016 )0.6(\f)]TJ /Span<>> BDC ( )Tj EMC 15.347 0 Td (\235\024\030\n\017\030\024\r\026\027\017\036\n )Tj 0.103 Tw -15.347 -1.218 Td [(\017\035\036\024\021\030\026\027\f\r\036\030\024\026\027\026\f\021\024\n\ \024\026. )0.6(\200)]TJ /Span<>> BDC ( )Tj EMC [(\020\030\031\023\023\036 ESD )0.5(\031)]TJ /Span<>> BDC ( )Tj EMC (2)Tj /Span<>> BDC ( )Tj EMC (\(3,9%\) )Tj 0.441 Tw T* (\023\026\006\017\036\027\021\024\r \r)Tj /Span<>> BDC ( )Tj EMC (\023\024\f\035\036\024\023\036\030\026\006\017\024\027\027\024\n \023\036\ \030\017\024\007\036 \030\026\r\017)Tj 0 Tw (-)Tj 0.16 Tw T* (\035\024\f\034 \022\030\024\r\024\021\036\004\036\027\017\036 \017)Tj /Span<>> BDC ( )Tj EMC (\024\002\035\026\f\021\017 \024\023\036\030\026\006\017\017, \024\f\021\026\ \027\024\r\022\026 )Tj 0.109 Tw T* [(\022\024\021\024\030\024\020\024 )0.5(\023\024\021\030\036\002\024\r\026\035\026 )0.6(\024\f\031\013\036\f\021\r\035\036\027\017\016 )0.6(\022\024\035\024\027\024\f\022\024\023\017\017 )]TJ 0.098 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\022\035\017\023\023\017\030\024\r\026\027\017\016 \022\030\024\r\024\021\ \024\004\026\013\036\020\024 \f\024\f\031\007\026, \004\021\024 \017)Tj /Span<>> BDC ( )Tj EMC (\002\t\035\024 )Tj 0 Tw T* (\031\f\023\036\001\027\024 \r\t\023\024\035\027\036\027\024 \(\230\026\002\ \035.)Tj /Span<>> BDC ( )Tj EMC (3\).)Tj 0.408 Tw T* (\203\026 \024\f\027\024\r\026\027\017\017 \026\027\026\035\017\026 \030\ \036\031\035\034\021\026\021\024\r \017\f\f\035\036\007\024\r\026\027\017\ \016 )Tj 0.178 Tw T* [(\031\f\021\026\027\024\r\035\036\027\024, )0.5(\004\021\024 )0.6(\r)]TJ /Span<>> BDC ( )Tj EMC 8.403 0 Td [(\022\024\027\021\030\024\035\034\027\024\005 \020\030\031\023\023\036 )0.6(\f\021\026\021\017\f\021\017\004\036)]TJ 0 Tw (-)Tj -0.014 Tw -8.403 -1.218 Td (\f\022\017 \027\026\004\017\n\024 \004\026\013\036 \031)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\034\027\t\b \030\036\020\017\f\021\030\017\030\024\r\026\035\ \024\f\034 \017\002\t)Tj 0 Tw (-)Tj 0.078 Tw T* (\021\024\004\027\024\036 \024\021\035\024\032\036\027\017\036 \032\017\030\ \026 \r)Tj /Span<>> BDC ( )Tj EMC (\023\024\007\f\035\017\017\f\021\024\n \f\035\024\036 \r)Tj /Span<>> BDC ( )Tj EMC (\024\027\036 )Tj 0.091 Tw T* (\027\024\r\024\024\002\030\026\024\r\026\027\017\016)Tj /Span<>> BDC ( )Tj EMC (\227 \r)Tj /Span<>> BDC ( )Tj EMC (15)Tj /Span<>> BDC ( )Tj EMC (\(29,4%\) \f\035\031\004\026\016\b, \r)Tj /Span<>> BDC ( )Tj EMC (\021\024 \r\030\036)Tj 0 Tw (-)Tj 0.127 Tw T* (\n\016 \022\026\022 \r)Tj /Span<>> BDC ( )Tj EMC (\024\f\027\024\r\027\024\005 \020\030\031\023\023\036 \023\024\007\024\002\ \027\024\036 \024\021\n\036\004\036\027\024 \035\017\001\034 )Tj 0.004 Tw T* (\031)Tj /Span<>> BDC ( )Tj EMC (6)Tj /Span<>> BDC ( )Tj EMC (\(11,5%\) \002\024\035\034\027\t\b \()Tj /T1_3 1 Tf 0 Tw (\032)Tj /T1_1 1 Tf 0.004 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,03\). \230\026\022\032\036 \002\t\035\024 \024\021\n\036\004\036\027\024\ , )Tj ET q 42.52 141.899 71.022 71.022 re W n q /GS0 gs 71.0216056 0 0 71.0216056 42.5196838 141.8997964 cm /Im0 Do Q Q BT 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 0.195 Tw 9 0 0 9 42.5197 122.5959 Tm (\026\t\240\r\002 1.)Tj 0 0 0 1 k /GS1 gs /T1_3 1 Tf ( \230\021\030\n\t\013\n\033\025\006\031\t\013\026\002 \032\031\016\031\013\ \203\025\002 \t\023\025\016\025\t\024\n\017 \n\005\n\023\n\006\013\025 )Tj 0.021 Tw 0 -1.2 TD (\t)Tj /Span<>> BDC ( )Tj EMC 0.647 0 Td [(\203\025\032\013\205\023\002\032\021\020\003 \032\026\016\032\031\016\n\003\ )0.5(\033\032\025)]TJ /Span<>> BDC ( )Tj EMC [(\205\030\026\023\031\021\025\025 )0.5(\r\033\025\024\031\023\025\026\023\022\021\n\202\n )0.6(\021\n)]TJ 0 Tw (-)Tj -0.647 -1.2 Td (\027\n\n\005\032\026\016\n\027\026\021\025\002 \n\005\n\030\n\006\021\n\017\ \013\025\001\013\025)Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 0.082 Tw T* [(Video 1)47(.)]TJ 0 0 0 1 k /GS1 gs /T1_3 1 Tf ( Endoscopic mucosal resection with a circumferential )Tj 0 Tw T* [(incision in the remov)16.2(al of colon epithelial neoplas)33.2(m)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\033\030\031\030\213\b)-20.9(\035\231\213\233\t \021\032)50(\b)42(\032\231\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj /T1_5 1 Tf 25 0 0 25 512.7771 56.0378 Tm (25)Tj ET endstream endobj 2480 0 obj <>stream AdobedC     '$''''$25552;;;;;;;;;;   GA!12"#3ABQSa $%&'()*456789:CDEFGHIJRTUVWXYZbcdefghijqrstuvwxyzӖ?Ujjjjjjjjjjjjjjjjjj`UaQzQ$)QWzd2M"X@㛛N˻*Vm;.6^M}iƴiqWCRY$ň<`-2r|┤;͗s| ̔S X e9d,ɬQjW9JH[P+I,.lԑw]⪹D%1b<}L'/%<=t=>?$d Z*0 9!iO ?v]'bM9Yc B)hySD)s޺N<*R#mdD$:^q(jP=<}%O9:tH܎ .hV)H`0(϶XlcR\H9"kP!Bm;.4^M7lRvEEEA5'4-EbYZR$QGI(2S 5:"-7`Ubɿ*r9M0d ,gwHH3GZ3,lzNЛ@]-q5S)mQǷ!bNY(&#>I(&fHda6}Y" 8A$()@ bW+"MYH0nWS@YDUN')Hn^|rPq秅@RPȩAU@! m厧ݖ;&Ia)L"baC[JXy.j<$-%(@Y@*D0h<ʛZ{~JAOU+YȘud"1w+adgfUuMazUQ ^*Q 4ܾԦ (SU5iR9 0 -4sNY*Gi@$ e1Fɬ2dM9\ȽwG(Dba4 YCAI.Jxytw}p%]EJQز˃9wuH\0 ) #iԴ˙!0Uh:dg7ѓ+(Dmn8?"7U#E rR8Ѵ݆l~s *Q#"&Xj JH(i94'$pJP|kȳ IENxP7fÅ$I$QuE'V) "J-&2668F\A(7$N|ܛH} ")!ko2,)d 8lIF)!ˆ#c;R| ꓂`u&P T4@mnff?GI$ '#c4@vv6|Md'.qI%DbZJ!"1dœ\>JxC  :W7QbITT9e E3@DBqԴ˙!0Umqy" cFB4" Ny,n.']5LdL XBn8fey*Tr tZ(RL!j륧e&$:e_Ô(80DW)2*b[AbACJO/BwP]eNRa 0 4Oϯ3/ P Uc j!=ssw9wA$|BË #mlMp!L쌟'^CR)nQcT&Χy@C(PB@cK`M,O6h$c8=9Ȣ/H(3$@bEfʓ"!&遇0+W c9U9YiITI)*MU ,B*::,YU8PP)X B!mK"nYB\ %!hYUggR"%%L ܌ݦ`UaW3ZRgzH*"QI P7X9.i< S@Pe9FV<.&{ wt0t%0҉e5j e8‹`doQDL`1FH%u9?$Nt/EZD4@9h$(mͰG[OZo4&Sܖ_7&S؈\ِ6%YJQ]5( JBf=c)<\@"xE隑MN KrIR(/2ɷLLdB4L7}>g  d*yYR"@LMFtrL(ɦ}*D( 9 \( l#oq6%2Tx"FEdP Gmhܹ4%IquYBIHP*Z!+B #[8&9$;\PS #hB,1Ԓp|zêe J8P#HUa'Vzp@zF=3VF\yHH&6cۥ@4DK.r-T#X`1fXHZ]I V[C Wl(,$dY=i #ꚂXVWz"\3F4`sRi %HX8T)@̴gxdHBaB.m5^O(&{Dɕ*LcdSh9I-Qiڢ%FÆ*wWwJ%2LBF~1%rxa\lfçcXc !c{L( USXHesu"+b=9Q4H#!#1זT{ LWVNrfD&-(z2++@nDUcy~O4ėl7s(TŻLi¯lbyY5)# I<΢+` P.?қϤ r)BVP cmM4_g DԺ2uBqT.CP_`HңXP<#"HM%'J(?/L`BmoaErʮ4'S'JhR2cԙj'R{+8*Rc-+&dƁШ6(c[vX>{Nɏ/(2c X/Hn Hӄ(bh)KF5qJM%%K+wQ)Bh1,7U) bP%rD0nU4&B_u$( T*シl'i3B`UcYc)f[|Sv3ʴ&S -B"q)”)c'$ *B+F%b ];,ʪB!;!Y!y:F4J7@('\VV0 3vh{7=^x0%rS\h-|Ƶ8 ` R< Ҵhͳw4$9!TE^P! ZbdL3hM;1D5ڳh!:$' ` 6p ֓,:dh K|":dswFɁATVSRU;rwY*j2|Ɠ_2 l$0[3gt] &RR&(DǶBqY6r(&(QTW0P(Ɣ. A,.S Z.Ίq* j7!qLRuI?(x'#WHOJ!DHM Ucyc)&X5岻(3"%LD[T7j54WHu2bV&50k,{F3$MDvF2SK" D8m,8و9^%U'PxB z0&([GWYeܠgrJTiJ)GwcuRbD@!u&ܳ-7%3IB"*-Z+&r(d氫.ҤE%#۳LؚU.;EUUA1L pqs&zӜh##]\w&%@=Dv뼝db S那n"mƙnF&{,)Kr) ̑k)ӤLŹD.cMbW-92\s_sEeHD Ea-3aIn"zK* KQ„ Ah2Ps%ez"Qnشȯ5ݦ&~ex{X!]PD BR0_(K3nPpypX0Bj Ye:(  h›S~q霁ܨ4UEbzX(ƌC*a2P6aq&pKiB;JJ҂21mrJ65]Yw9Dɬg\0@ Q@(mo=%h%I I)>stream endstream endobj 2478 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 0 0 0 1 k /GS1 gs /T1_0 1 Tf -0.017 Tw 10 0 0 10 70.8661 432.5579 Tm [(\035\026\021\036\030\026\035\034\027\024\005 )0.6(\020\030\026\027\017\006\t )0.5(\030\036\036\022\006\017\017. )0.6(\212\026\035\036\036, )0.5(\007\035\016 )0.5(\f\027\017\032\036\027\017\016 )]TJ -0.075 Tw 0 -1.218 TD (\030\017\f\022\026 \021\036\030\n\017\004\036\f\022\024\020\024 \r\024\007\ \036\005\f\021\r\017\016 \027\026)Tj /Span<>> BDC ( )Tj EMC (\020\035\031\002\024\022\017\036 \f\035\024\017 \022\017)Tj 0 Tw (-)Tj -0.045 Tw T* (\001\036\004\027\024\005 \f\021\036\027\022\017, \r)Tj /Span<>> BDC ( )Tj EMC (\024\002\016\026\021\036\035\034\027\024\n \023\024\030\016\007\022\036\ , \023\030\024\r\024\007\017\035\026\f\034 )Tj 0.252 Tw T* [(\023\024\r\021\024\030\027\026\016 )0.6(\017\027\255\036\022\006\017\016 )0.5(\023\035\026\n\024\026\n\036\013\026\033\013\036\020\024 )0.5(\030\026\f\021\r\024\030\026 )]TJ 0.131 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\023\024\007\f\035\017\017\f\021\t\005 \f\035\024\005 \r)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\036\022\006\017\017 \027\024\r\024\024\002\030\026\024\r\026\ \027\017\016. )Tj 0.197 Tw T* (\003\026\021\036\n, \023\024\f\035\036 \023\024\007\002\024\030\026 \f\024\ \024\021\r\036\021\f\021\r\031\033\013\036\005 \023\024)Tj /Span<>> BDC ( )Tj EMC (\030\026\n\036\030\031 )Tj 0.043 Tw T* [(\220\027\007\024\f\022\024\023\017\004\036\f\022\024\005 )0.5(\023\036\021\035\017, \036\036 \031\f\021\026\027\026\r\035\017\r\026\035\ \017 \027\036\023\024\f\030\036\007)]TJ 0 Tw (-)Tj 0.134 Tw T* (\f\021\r\036\027\027\024 \r)Tj /Span<>> BDC ( )Tj EMC (\024\027\031 \030\026\030\036\026, \026\021\016\020\017\r\026\035\017\ \017)Tj /Span<>> BDC ( )Tj EMC (\024\f\031\013\036\f\021\r\035\016\035\017 )Tj 0.08 Tw T* [(\220\035\036\022\021\030\024\220\022\f\006\017\017\033 )0.5(\024\023\031\b\024\035\017. \215\024)]TJ /Span<>> BDC ( )Tj EMC (\026\r\036\030\001\036\027\017\017 \031\007\026\035\036\027\017\016 )Tj 0.261 Tw T* (\024\023\031\b\024\035\017 \023\024\f\035\036\024\023\036\030\026\006\017\ \024\027\027\026\016 \023\024\r\036\030\b\027\024\f\021\034 \024\006\036\ \027\017\r\026)Tj 0 Tw (-)Tj 0.191 Tw T* [(\035\026\f\034 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 3.136 0 Td [(\f\024\024\021\r\036\021\f\021\r\017\017 )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC 6.749 0 Td [(\221\017\007\027\036\005\f\022\024\005 )0.6(\022\035\026\f\f\017\235\017\022\026\006\017\036\005 )]TJ 0.215 Tw -9.885 -1.218 Td (\007\035\016 \024\023\030\036\007\036\035\036\027\017\016 \020\035\031\002\ \017\027\t \021\036\030\n\017\004\036\f\022\024\020\024 \023\024\r\030\036\ \032\007\036)Tj 0 Tw (-)Tj 0.039 Tw T* (\027\017\016 \022\017\001\036\004\027\024\005 \f\021\036\027\022\017 [19\ ]. \200\017\031\026\035\034\027\024 \024\023\030\036\007\036\035\016\036\ \n\t\036 )Tj 0.176 Tw T* (\f\024\f\031\007\t \r)Tj /Span<>> BDC ( )Tj EMC [(\024\002\030\026\024\r\026\r\001\036\n\f\016 \007\036\235\036\022\021\036\ )0.5(\024\002\030\026\002\026\021\t\r\026\035\017\f\034 )]TJ 0.238 Tw T* (\020\036\n\024\f\021\026\021\017\004\036\f\022\017\n\017 \013\017\023\006\ \026\n\017, \017, \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\027\036\024\002\b\024\007\017\n\024\f\021\017, )Tj -0.009 Tw T* [(\022\030\026\016 )0.5(\f\235\024\030\n\017\030\024\r\026\027\027\024\020\024 )0.6(\007\036\235\036\022\021\026 )0.5(\f\021\036\027\022\017 )0.6(\022\017\001\022\017 )0.5(\f\024\036\007\017)]TJ 0 Tw (-)Tj 0.21 Tw T* (\027\016\035\017\f\034 \007\030\031\020 \f)Tj /Span<>> BDC ( )Tj EMC (\007\030\031\020\024\n \f)Tj /Span<>> BDC ( )Tj EMC (\023\024\n\024\013\034\033 \220\027\007\024\f\022\024\023\017\004\036\f\022\ \017\b )Tj 0.629 Tw T* (\022\035\017\023\f. \211\007\026\035\036\027\027\024\036 \027\024\r\024\024\ \002\030\026\024\r\026\027\017\036 \017\r\035\036\022\026\035\024\f\034\ )Tj -0.025 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\235\017\022\f\017\030\024\r\026\035\024\f\034 \027\026)Tj /Span<>> BDC ( )Tj EMC (\023\036\027\024\023\035\026\f\021\024\r\024\005 \023\035\026\f\021\017\027\ \036 \f)Tj /Span<>> BDC ( )Tj EMC (\006\036\035\034\033 )Tj 0.063 Tw T* (\022\024\030\030\036\022\021\027\024\005 \024\006\036\027\022\017 \022\030\ \026\036\r \030\036\036\022\006\017\017. \200)Tj /Span<>> BDC ( )Tj EMC (\f\035\031\004\026\036 \027\036\r\024)Tj 0 Tw (-)Tj 0.247 Tw T* (\n\024\032\027\024\f\021\017 \031\007\026\035\036\027\017\016 \027\024\r\ \024\024\002\030\026\024\r\026\027\017\016 \024\007\027\017\n \235\030\026\ \020)Tj 0 Tw (-)Tj 0.08 Tw T* (\n\036\027\021\024\n \023\030\017\027\017\n\026\035\024\f\034 \030\036\001\ \036\027\017\036 \024)Tj /Span<>> BDC ( )Tj EMC (\022\024\027\r\036\030\f\017\017 \r)Tj /Span<>> BDC ( )Tj EMC (\007\030\031\020\024\005 )Tj 0 Tw T* (\n\036\021\024\007 \220\027\007\024\f\022\024\023\017\004\036\f\022\024\020\ \024 \r\n\036\001\026\021\036\035\034\f\021\r\026.)Tj 0.051 Tw T* (ESD \r)Tj /Span<>> BDC ( )Tj EMC (\022\024\027\021\030\024\035\034\027\024\005 \020\030\031\023\023\036 \r\ \t\023\024\035\027\016\035\026\f\034 \023\024)Tj /Span<>> BDC ( )Tj EMC (\f\021\026\027\007\026\030\021)Tj 0 Tw (-)Tj 0.178 Tw T* (\027\024\005 \n\036\021\024\007\017\022\036. \215\024\f\035\036 \f\024\007\ \026\027\017\016 \023\024\007\f\035\017\017\f\021\024\020\024 \035\017\235\ )Tj 0 Tw (-)Tj 0.018 Tw T* (\021\017\027\020\026 \r\t\023\024\035\027\016\035\f\016 \030\026\030\036\  \f\035\017\017\f\021\024\005 \024\002\024\035\024\004\022\017 \r\024\022\ \030\031\020 )Tj -0.009 Tw T* [(\024\023\031\b\024\035\017 )0.6(\f)]TJ /Span<>> BDC ( )Tj EMC 4.267 0 Td [(\024\021\f\021\031\023\024\n )0.6(\024\021 )0.6(\036\036 )0.5(\022\030\026\036\r )0.6(\027\026)]TJ /Span<>> BDC ( )Tj EMC 9.986 0 Td (2\2263)Tj /Span<>> BDC ( )Tj EMC 1.779 0 Td [(\n\n. )0.6(\003\026\021\036\n )0.5(\023\030\024)]TJ 0 Tw (-)Tj 0.11 Tw -16.032 -1.218 Td [(\r\024\007\017\035\026\f\034 )0.5(\027\036\023\024\f\030\036\007\f\021\r\036\027\027\024 )0.5(\023\024\007\f\035\017\017\f\021\026\016 )0.6(\007\017\f\f\036\022\006\017\016, )]TJ 0.303 Tw T* (\023\030\017)Tj /Span<>> BDC ( )Tj EMC 2.056 0 Td [(\022\024\021\024\030\024\005 )0.5(\024\023\031\b\024\035\034 )0.6(\024\021\f\036\023\026\030\024\r\t\r\026\035\026\f\034 )0.5(\024\021 )0.6(\f\021\036\027\022\017 )]TJ 0.112 Tw -2.056 -1.218 Td [(\022\017\001\022\017, )0.5(\026 )0.5(\026\021\036\n )0.6(\024\f\031\013\036\f\021\r\035\016\035\f\016 )0.5(\r\017\031\026\035\034\027\t\005 )0.6(\022\024\027\021\030\024\035\034 )]TJ 0.262 Tw 23.244 35.316 Td (\024\002\030\026\024\r\026\r\001\036\020\024\f\016 \007\036\235\036\022\ \021\026 \f\021\036\027\022\017 \022\017\001\022\017 \017, \r)Tj /Span<>> BDC ( )Tj EMC (\030\016\007\036 )Tj 0.025 Tw T* (\f\035\031\004\026\036\r, \036\020\024 \026\022\030\t\021\017\036 \022\035\ \017\023\f\026\n\017. \210\023\036\030\026\006\017\024\027\027\t\005 \023\ \030\036)Tj 0 Tw (-)Tj 0.105 Tw T* (\023\026\030\026\021 \017\r\035\036\022\026\035\f\016 \007\035\016 \023\ \026\021\024\n\024\030\235\024\035\024\020\017\004\036\f\022\024\020\024\ \017\f\f\035\036)Tj 0 Tw (-)Tj 0.191 Tw T* (\007\024\r\026\027\017\016. \215\024\f\035\036 \r\t\023\017\f\022\017 \017\ )Tj /Span<>> BDC ( )Tj EMC (\f\021\026\006\017\024\027\026\030\026 \023\026\006\017\036\027\021\026\n\ , )Tj -0.014 Tw T* (\022\024\021\024\030\t\n \024\023\031\b\024\035\034 \002\t\035\026 \031\007\ \026\035\036\027\026 \036\007\017\027\t\n \002\035\024\022\024\n, \022\024\ \027\021)Tj 0 Tw (-)Tj -0.006 Tw T* (\030\024\035\034\027\026\016 \022\024\035\024\027\024\f\022\024\023\017\016\ \002\t\035\026 \030\036\022\024\n\036\027\007\024\r\026\027\026 \004\036\ \030\036 12 )Tj -0.044 Tw T* (\n\036\f\016\006\036\r, \026)Tj /Span<>> BDC ( )Tj EMC (\r)Tj /Span<>> BDC ( )Tj EMC (\f\035\031\004\026\036 \235\030\026\020\n\036\027\021\026\006\017\017 \023\ \030\036\023\026\030\026\021\026)Tj /Span<>> BDC ( )Tj EMC (\227 \004\036\030\036 )Tj 0 Tw T* (3\2266)Tj /Span<>> BDC ( )Tj EMC (\n\036\f\016\006\036\r [20,21].)Tj 0.22 Tw T* (\200 \023\030\024\006\036\f\f\036 \031\007\026\035\036\027\017\016 \027\024\ \r\024\024\002\030\026\024\r\026\027\017\005 \220\027\007\024\f\022\024\ \023\017)Tj 0 Tw (-)Tj 0.089 Tw T* (\004\036\f\022\017\n\017 \n\036\021\024\007\026\n\017 C-EMR \017)Tj /Span<>> BDC ( )Tj EMC (ESD \r\030\026\004\017-\220\027\007\024\f\022\024\023\017\f\021\t )Tj 0.54 Tw T* [(\030\036\020\017\f\021\030\017\030\024\r\026\035\017 )0.6(\021\036\b\027\017\004\036\f\022\017\036 )0.6(\f\035\024\032\027\024\f\021\017, )0.5(\022\024\021\024\030\t\036 )]TJ 0.401 Tw T* [(\023\024\021\036\027\006\017\026\035\034\027\024 )0.5(\n\024\020\035\017 \031\f\035\024\032\027\016\021\034 \024\023\036\030\026\ \006\017\033, \031\r\036\035\017)]TJ 0 Tw (-)Tj 0.283 Tw T* (\004\017\r\026\016 \r\030\036\n\016 \r\n\036\001\026\021\036\035\034\f\021\ \r\026, \r\036\030\024\016\021\027\024\f\021\034 \030\026\r\017\021\017\ \016 )Tj 0.086 Tw T* (\024\f\035\024\032\027\036\027\017\005 \017)Tj /Span<>> BDC ( )Tj EMC (\022\024\027\r\036\030\f\017\017. \025)Tj /Span<>> BDC ( )Tj EMC (\007\026\027\027\t\n \f\035\024\032\027\024\f\021\016\n \024\021)Tj 0 Tw (-)Tj 0.473 Tw T* (\027\024\f\017\035\017\f\034: \027\036\031\007\024\002\027\024\036 \030\026\ \f\023\024\035\024\032\036\027\017\036 \024\023\031\b\024\035\017 \(\023\ \024 )Tj 0.186 Tw T* [(\002\030\t\032\036\036\004\027\024\n\031 )0.5(\022\030\026\033 )0.5(\023\030\026\r\024\020\024 \017)]TJ /Span<>> BDC ( )Tj EMC 13.316 0 Td [(\035\036\r\024\020\024 )0.5(\017\020\017\002\024\r \024\002\024)]TJ 0 Tw (-)Tj 0.08 Tw -13.316 -1.218 Td (\007\024\004\027\024\005 \022\017\001\022\017, \023\024)Tj /Span<>> BDC ( )Tj EMC (\026\007\027\036\005 \023\024\r\036\030\b\027\024\f\021\017 \f\022\035\026\ \007\022\017 \022\017\001)Tj 0 Tw (-)Tj 0.021 Tw T* (\022\017, \r)Tj /Span<>> BDC ( )Tj EMC (\024\002\035\026\f\021\017 \027\017\032\027\036\005 \020\031\002\t \017\035\ \036\024\006\036\022\026\035\034\027\024\020\024 \022\035\026\023\026\027\ \026\), )Tj 0.219 Tw T* [(\026\021\030\031\007\027\016\033\013\036\036 )0.5(\030\036\026\035\017\026\006\017\033 \026\007\036\022\r\026\021\027\024\ \020\024 \031\020\035\026 \026\021\026\022\017, )]TJ 0.112 Tw T* [(\r\r\017\007\031 \024\020\030\026\027\017\004\036\027\017\016 )0.5(\023\024\007\r\017\032\027\024\f\021\017 \007\017\f\021\026\035\034\027\024\ \020\024 \022\024\027\006\026 )]TJ 0.165 Tw T* (\220\027\007\024\f\022\024\023\026 \f)Tj /Span<>> BDC ( )Tj EMC (\n\026\022\f\017\n\026\035\034\027\t\n \027\026\021\016\032\036\027\017\036\ \n \021\016\020 \036\020\024 \030\031)Tj 0 Tw (-)Tj 0.022 Tw T* (\022\024\016\021\022\017; \027\026\035\017\004\017\036 \017\002\t\021\024\ \004\027\024\020\024 \022\024\035\017\004\036\f\021\r\026 \032\017\030\026\ , \235\017\002)Tj 0 Tw (-)Tj 0.04 Tw T* (\030\024\026, \022\030\031\023\027\t\b \f\024\f\031\007\024\r \r)Tj /Span<>> BDC ( )Tj EMC (\023\024\007\f\035\017\017\f\021\024\n \f\035\024\036; \031\f\017\035\036\ \027)Tj 0 Tw (-)Tj 0.106 Tw T* (\027\031\033 \023\036\030\017\f\021\026\035\034\021\017\022\031 \(\022\024\ \020\007\026 \023\036\030\017\f\021\026\035\034\021\017\004\036\f\022\017\ \036 \r\024\035\027\t )Tj 0.067 Tw T* (\022\017\001\022\017 \026\027\017\n\026\035\017 \002\024\035\036\036 \023\ \024\035\024\r\017\027\t \r\030\036\n\036\027\017 \r\f\036\005 \024\023\036\ )Tj 0 Tw (-)Tj 0.092 Tw T* (\030\026\006\017\017\). \215\024\035\031\004\036\027\027\t\036 \030\036\ \031\035\034\021\026\021\t \002\t\035\017 \017\f\023\024\035\034\024\r\026\ \027\t )Tj 0.133 Tw T* (\023\030\017)Tj /Span<>> BDC ( )Tj EMC (\026\027\026\035\017\036 \235\026\022\021\024\030\024\r \030\017\f\022\026\ \022\024\027\r\036\030\f\017\017 \220\027\007\024\f\022\024\023\017)Tj 0 Tw (-)Tj T* (\004\036\f\022\024\020\024 \r\n\036\001\026\021\036\035\034\f\021\r\026.\ )Tj 0.581 Tw T* (\215\036\030\r\017\004\027\t\036 \007\026\027\027\t\036 \024)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\026\b \002\t\035\017 \r\027\036\f\036\027\t\ )Tj 0.218 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC [(\f\023\036\006\017\026\035\034\027\024 \030\026\030\026\002\024\021\026\ \027\027\031\033 )0.5(\220\035\036\022\021\030\024\027\027\031\033 \021\026\002\035\017\006\031\ )]TJ 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0 Tw 9 0 0 9 70.8661 730.483 Tm (\020\004\206\f\t\204\004 2 .)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf ( \206\026\032\026\013\024\031\032\025\t\024\025\013\026 \r\033\025\024\031\ \023\025\026\023\022\021\020\004 \021\n\027\n\n\005\032\026\016\n\027\026\ \021\025\017 \027)Tj /Span<>> BDC ( )Tj EMC (\202\032\205\033\033\026\004)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0 -1.2 TD [(T)48(able 2)16(.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf [( Character)-36.9(istics of colon neoplas)33.2(ms)]TJ ET 0 0 0 1 K 0.5 w /GS2 gs q 1 0 0 1 70.8661 715.181 cm 0 0 m 181.667 0 l S Q q 1 0 0 1 71.1161 694.3618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 252.5335 715.181 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 252.5335 694.3618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 343.2421 715.181 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 343.2421 694.3618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 433.9508 715.181 cm 0 0 m 90.959 0 l S Q q 1 0 0 1 433.9508 694.3618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 524.6594 694.3618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 70.8661 694.1118 cm 0 0 m 181.667 0 l S Q q 1 0 0 1 71.1161 682.9005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 252.5335 694.1118 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 343.2421 694.1118 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 433.9508 694.1118 cm 0 0 m 90.959 0 l S Q q 1 0 0 1 524.6594 682.9005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 682.6505 cm 0 0 m 181.667 0 l S Q q 1 0 0 1 71.1161 671.4392 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 252.5335 682.6505 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 252.5335 671.4392 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 343.2421 682.6505 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 343.2421 671.4392 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 433.9508 682.6505 cm 0 0 m 90.959 0 l S Q q 1 0 0 1 433.9508 671.4392 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 671.4392 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 671.1892 cm 0 0 m 181.667 0 l S Q q 1 0 0 1 71.1161 659.9779 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 252.5335 671.1892 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 252.5335 659.9779 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 343.2421 671.1892 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 343.2421 659.9779 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 433.9508 671.1892 cm 0 0 m 90.959 0 l S Q q 1 0 0 1 433.9508 659.9779 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 659.9779 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 659.7279 cm 0 0 m 181.667 0 l S Q q 1 0 0 1 71.1161 648.5166 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 252.5335 659.7279 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 252.5335 648.5166 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 343.2421 659.7279 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 343.2421 648.5166 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 433.9508 659.7279 cm 0 0 m 90.959 0 l S Q q 1 0 0 1 433.9508 648.5166 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 648.5166 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 648.2666 cm 0 0 m 181.667 0 l S Q q 1 0 0 1 71.1161 637.0554 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 252.5335 648.2666 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 343.2421 648.2666 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 433.9508 648.2666 cm 0 0 m 90.959 0 l S Q q 1 0 0 1 524.6594 637.0554 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 636.8054 cm 0 0 m 181.667 0 l S Q q 1 0 0 1 71.1161 625.5941 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 252.5335 636.8054 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 252.5335 625.5941 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 343.2421 636.8054 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 343.2421 625.5941 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 433.9508 636.8054 cm 0 0 m 90.959 0 l S Q q 1 0 0 1 433.9508 625.5941 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 625.5941 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 625.3441 cm 0 0 m 181.667 0 l S Q q 1 0 0 1 71.1161 614.1328 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 252.5335 625.3441 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 252.5335 614.1328 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 343.2421 625.3441 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 343.2421 614.1328 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 433.9508 625.3441 cm 0 0 m 90.959 0 l S Q q 1 0 0 1 433.9508 614.1328 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 614.1328 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 613.8828 cm 0 0 m 181.667 0 l S Q q 1 0 0 1 71.1161 602.6715 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 252.5335 613.8828 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 252.5335 602.6715 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 343.2421 613.8828 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 343.2421 602.6715 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 433.9508 613.8828 cm 0 0 m 90.959 0 l S Q q 1 0 0 1 433.9508 602.6715 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 602.6715 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 602.4215 cm 0 0 m 181.667 0 l S Q q 1 0 0 1 71.1161 591.2102 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 252.5335 602.4215 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 252.5335 591.2102 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 343.2421 602.4215 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 343.2421 591.2102 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 433.9508 602.4215 cm 0 0 m 90.959 0 l S Q q 1 0 0 1 433.9508 591.2102 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 591.2102 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 590.9602 cm 0 0 m 181.667 0 l S Q q 1 0 0 1 71.1161 579.7489 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 252.5335 590.9602 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 343.2421 590.9602 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 433.9508 590.9602 cm 0 0 m 90.959 0 l S Q q 1 0 0 1 524.6594 579.7489 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 579.4989 cm 0 0 m 181.667 0 l S Q q 1 0 0 1 71.1161 568.2876 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 252.5335 579.4989 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 252.5335 568.2876 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 343.2421 579.4989 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 343.2421 568.2876 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 433.9508 579.4989 cm 0 0 m 90.959 0 l S Q q 1 0 0 1 433.9508 568.2876 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 568.2876 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 568.0376 cm 0 0 m 181.667 0 l S Q q 1 0 0 1 71.1161 556.8264 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 252.5335 568.0376 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 252.5335 556.8264 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 343.2421 568.0376 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 343.2421 556.8264 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 433.9508 568.0376 cm 0 0 m 90.959 0 l S Q q 1 0 0 1 433.9508 556.8264 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 556.8264 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 556.5764 cm 0 0 m 181.667 0 l S Q q 1 0 0 1 71.1161 545.3651 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 252.5335 556.5764 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 252.5335 545.3651 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 343.2421 556.5764 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 343.2421 545.3651 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 433.9508 556.5764 cm 0 0 m 90.959 0 l S Q q 1 0 0 1 433.9508 545.3651 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 545.3651 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 545.1151 cm 0 0 m 181.667 0 l S Q q 1 0 0 1 71.1161 533.9038 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 252.5335 545.1151 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 252.5335 533.9038 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 343.2421 545.1151 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 343.2421 533.9038 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 433.9508 545.1151 cm 0 0 m 90.959 0 l S Q q 1 0 0 1 433.9508 533.9038 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 533.9038 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 533.6538 cm 0 0 m 181.667 0 l S Q q 1 0 0 1 71.1161 522.4425 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 252.5335 533.6538 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 252.5335 522.4425 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 343.2421 533.6538 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 343.2421 522.4425 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 433.9508 533.6538 cm 0 0 m 90.959 0 l S Q q 1 0 0 1 433.9508 522.4425 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 522.4425 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 522.1925 cm 0 0 m 181.667 0 l S Q q 1 0 0 1 71.1161 510.9812 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 252.5335 522.1925 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 252.5335 510.9812 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 343.2421 522.1925 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 343.2421 510.9812 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 433.9508 522.1925 cm 0 0 m 90.959 0 l S Q q 1 0 0 1 433.9508 510.9812 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 510.9812 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 510.7312 cm 0 0 m 181.667 0 l S Q q 1 0 0 1 71.1161 499.5199 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 252.5335 510.7312 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 343.2421 510.7312 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 433.9508 510.7312 cm 0 0 m 90.959 0 l S Q q 1 0 0 1 524.6594 499.5199 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 499.2699 cm 0 0 m 181.667 0 l S Q q 1 0 0 1 71.1161 488.0587 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 252.5335 499.2699 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 252.5335 488.0587 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 343.2421 499.2699 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 343.2421 488.0587 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 433.9508 499.2699 cm 0 0 m 90.959 0 l S Q q 1 0 0 1 433.9508 488.0587 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 487.8087 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 70.8661 487.8087 cm 0 0 m 181.667 0 l S Q q 1 0 0 1 71.1161 476.5974 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 252.5335 487.8087 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 252.5335 476.5974 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 343.2421 487.8087 cm 0 0 m 90.959 0 l S Q q 1 0 0 1 343.2421 476.5974 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 433.9508 476.5974 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 476.5974 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 70.8661 476.3474 cm 0 0 m 181.667 0 l S Q q 1 0 0 1 252.5335 476.3474 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 343.2421 476.3474 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 433.9508 476.3474 cm 0 0 m 90.959 0 l S Q BT /GS1 gs /T1_1 1 Tf 8 0 0 8 145.0851 701.7465 Tm (\200\004\006\004\214\r\003\006)Tj 17.784 0.6 Td (C-EMR)Tj -0.453 -1.2 Td (\()Tj /T1_3 1 Tf (n)Tj /T1_1 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (52\))Tj 12.318 1.2 Td (ESD)Tj -0.979 -1.2 Td (\()Tj /T1_3 1 Tf (n)Tj /T1_1 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (51\))Tj /T1_3 1 Tf 12.849 0.6 Td (p)Tj /T1_0 1 Tf -50.41 -2.033 Td (\215\026\030\017\032\f\022\026\016 \022\035\026\f\f\017\235\017\022\026\006\ \017\016)Tj 0 -1.433 TD (0-Is)Tj 26.034 0 Td (9)Tj /Span<>> BDC ( )Tj EMC (\(17,3%\))Tj 11.589 0 Td (4)Tj /Span<>> BDC ( )Tj EMC (\(7,8%\))Tj 12.205 0 Td (0,2*)Tj -49.827 -1.433 Td (0-IIa)Tj 25.784 0 Td (40)Tj /Span<>> BDC ( )Tj EMC (\(76,9%\))Tj 11.339 0 Td (45)Tj /Span<>> BDC ( )Tj EMC (\(88,3%\))Tj 12.705 0 Td (0,2*)Tj -49.827 -1.433 Td (0-Is)Tj /Span<>> BDC ( )Tj EMC (+)Tj /Span<>> BDC ( )Tj EMC (0-IIa)Tj 26.284 0 Td (3)Tj /Span<>> BDC ( )Tj EMC (\(5,8%\))Tj 11.339 0 Td (2)Tj /Span<>> BDC ( )Tj EMC (\(3,9%\))Tj 12.205 0 Td (1,0*)Tj -49.827 -1.433 Td (\215\030\026\020\n\026\021\017\004\036\f\022\026\016 \022\035\026\f\f\017\ \235\017\022\026\006\017\016)Tj 0 -1.433 TD (LST-GH)Tj 25.784 0 Td (24)Tj /Span<>> BDC ( )Tj EMC (\(46,2%\))Tj 11.339 0 Td (18)Tj /Span<>> BDC ( )Tj EMC (\(35,3%\))Tj 12.455 0 Td (0,3**)Tj -49.577 -1.433 Td (LST-GM)Tj 26.284 0 Td (3)Tj /Span<>> BDC ( )Tj EMC (\(5,8%\))Tj 11.339 0 Td (5)Tj /Span<>> BDC ( )Tj EMC (\(9,8%\))Tj 12.205 0 Td (0,5*)Tj -49.827 -1.433 Td (LST-NG-F\213)Tj 25.784 0 Td (15)Tj /Span<>> BDC ( )Tj EMC (\(28,8%\))Tj 11.339 0 Td (24)Tj /Span<>> BDC ( )Tj EMC (\(47,1%\))Tj 12.205 0 Td (0,06**)Tj -49.327 -1.433 Td (LST-NG-PD)Tj 26.284 0 Td (1)Tj /Span<>> BDC ( )Tj EMC (\(1,9%\))Tj 12.797 0 Td (0)Tj 10.746 0 Td (1,0*)Tj -49.827 -1.433 Td (\025\035\026\f\f\017\235\017\022\026\006\017\017 S.)Tj /Span<>> BDC ( )Tj EMC (Kudo \017)Tj /Span<>> BDC ( )Tj EMC (T.)Tj /Span<>> BDC ( )Tj EMC (Kimura)Tj 0 -1.433 TD (IIIs)Tj 26.034 0 Td (8)Tj /Span<>> BDC ( )Tj EMC (\(15,4%\))Tj 11.339 0 Td (9)Tj /Span<>> BDC ( )Tj EMC (\(17,6%\))Tj 12.455 0 Td (0,8*)Tj -49.827 -1.433 Td (IIIL)Tj 25.784 0 Td (23)Tj /Span<>> BDC ( )Tj EMC (\(44,2%\))Tj 11.339 0 Td (12)Tj /Span<>> BDC ( )Tj EMC (\(23,5%\))Tj 12.205 0 Td (0,03**)Tj -49.327 -1.433 Td (IIIL)Tj /Span<>> BDC ( )Tj EMC (+)Tj /Span<>> BDC ( )Tj EMC (IV)Tj 26.034 0 Td (7)Tj /Span<>> BDC ( )Tj EMC (\(13,5%\))Tj 11.589 0 Td (5)Tj /Span<>> BDC ( )Tj EMC (\(9,8%\))Tj 12.205 0 Td (0,7*)Tj -49.827 -1.433 Td (IV)Tj 26.284 0 Td (3)Tj /Span<>> BDC ( )Tj EMC (\(5,8%\))Tj 11.339 0 Td (2)Tj /Span<>> BDC ( )Tj EMC (\(3,9%\))Tj 12.205 0 Td (1,0*)Tj -49.827 -1.433 Td (IIIs)Tj /Span<>> BDC ( )Tj EMC (+)Tj /Span<>> BDC ( )Tj EMC (IIIL)Tj 26.284 0 Td (2)Tj /Span<>> BDC ( )Tj EMC (\(3,8%\))Tj 11.339 0 Td (4)Tj /Span<>> BDC ( )Tj EMC (\(7,8%\))Tj 12.205 0 Td (0,4*)Tj -49.827 -1.433 Td (II-O)Tj 26.034 0 Td (9)Tj /Span<>> BDC ( )Tj EMC (\(17,3%\))Tj 11.089 0 Td (19)Tj /Span<>> BDC ( )Tj EMC (\(37,3%\))Tj 12.205 0 Td (0,03**)Tj -49.327 -1.433 Td (\025\035\026\f\f\017\235\017\022\026\006\017\016 Y.)Tj /Span<>> BDC ( )Tj EMC (Sano)Tj T* (I)Tj 26.034 0 Td (9)Tj /Span<>> BDC ( )Tj EMC (\(17,3%\))Tj 11.089 0 Td (17)Tj /Span<>> BDC ( )Tj EMC (\(33,3%\))Tj 12.205 0 Td (0,06**)Tj -49.327 -1.433 Td (II)Tj 25.784 0 Td (43)Tj /Span<>> BDC ( )Tj EMC (\(82,7%\))Tj 11.339 0 Td (34)Tj /Span<>> BDC ( )Tj EMC (\(66,7%\))Tj /T1_2 1 Tf 7 0 0 7 70.8661 464.8628 Tm (\032\025\003\031\006\026\021\025\031: \032*)Tj /Span<>> BDC ( )Tj EMC (\227 \024\n\006\021\020\017 \013\032\025\024\031\032\025\017 \225\025\001\ \031\032\026; \032**)Tj /Span<>> BDC ( )Tj EMC (\227 \013\032\025\024\031\032\025\017 \232)Tj 4.081 0 0 4.081 262.1239 467.1938 Tm (2)Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\033\030\031\030\213\b)-20.9(\035\231\213\233\t \021\032)50(\b)42(\032\231\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj -51.938 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 23, \023\0221)69(, 202)69(4)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 23, \023\0221)69(, 202)69(4)]TJ /T1_5 1 Tf 25 0 0 25 28.1902 56.0378 Tm (24)Tj ET endstream endobj 2477 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\235\001\201\025\006\n)10(\025\221\220\017\016\006\n\013\205 \024\215\n)10(\025)21(\222)21(\232\n)-9.9(\026)11(\025\024\220\205 \006\022\227\220\002\n\215\007\205\002\001\020\024 \002\ \013\222\002\016\222\025\024 )]TJ 0 -1 TD [(\006)-10(\007\220\222\220\006)-9.9(\026)11(\025\203 \025\f\025\007\025\017\n\220 \r\022\007\016\017\016\001\220\220\ \025\221\215)21.1(\207\025\007\016\203 \025\f\025\201\025\017\001\025\203 \n\220\n\220. )]TJ T* [(\033\016\222)21(\215\007\216)21(\026)11(\013\026\020 \002\013\001\201\025\024\220\222\220\002\025\r\013\001\001\025\ \202)10(\025 \220\006\006)-10(\007\016\201\025\r\013\001\220\205.)]TJ 34.507 2 Td [(Endoscopic mucosal r)31(esection with a cir)31(cumfer)31.1(ential incision in th)11(e )]TJ 2.851 -1 Td [(r)31(emov)10(al of colon neoplasms. Results of a r)21(andomiz)10.1(ed trial.)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0.658 Tw 10 0 0 10 42.5197 566.5159 Tm (\220\023\017\021\036\035\017\026\035\034\027\t\b \027\024\r\024\024\002\030\ \026\024\r\026\027\017\005 \021\024\035\f\021\024\005 \022\017\001\022\017\ )Tj 0.12 Tw 0 -1.218 TD [(\030\026\n\036\030\026\n\017 )0.5(\002\024\035\036\036 20 \n\n )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC [(\n\026\022\f\017\n\026\035\034\027\024\n )0.5(\017\n\036\030\036\027\017\017 )]TJ 0 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\f\030\026\r\027\036\027\017\017 \f)Tj /Span<>> BDC ( )Tj EMC (ESD [8,12].)Tj 0.036 Tw T* (\200 \220\021\024\005 \f\r\016\017 \007\035\016 \024\023\030\036\007\036\ \035\036\027\017\016 \220\235\235\036\022\021\017\r\027\024\f\021\017 \017\ )Tj /Span<>> BDC ( )Tj EMC (\002\036)Tj 0 Tw (-)Tj -0.032 Tw T* (\024\023\026\f\027\024\f\021\017 \017\f\023\024\035\034\024\r\026\027\017\ \016 \n\036\021\024\007\017\022\017 C-EMR \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\031\007\026\035\036)Tj 0 Tw (-)Tj 0.083 Tw T* (\027\017\017 \022\030\031\023\027\t\b \220\023\017\021\036\035\017\026\035\ \034\027\t\b \007\024\002\030\024\022\026\004\036\f\021\r\036\027\027\t\b\ \027\024)Tj 0 Tw (-)Tj 0.039 Tw T* (\r\024\024\002\030\026\024\r\026\027\017\005 \021\024\035\f\021\024\005\ \022\017\001\022\017 \027\026\n\017 \002\t\035\024 \023\030\024\r\036\007\ \036\027\024 )Tj 0 Tw T* (\023\030\024\f\023\036\022\017\021\r\027\024\036 \030\026\027\007\024\n\017\ \017\030\024\r\026\027\027\024\036 \017\f\f\035\036\007\024\r\026\027\017\ \036.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.01 Tc 0.018 Tw 14 0 0 14 42.5896 444.7359 Tm [(\f\026\017\031\034\022\024\232)5( \031)5(\016)-18.3(\240\034)-31(\024)35(\037\226\232)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0 Tc -0.018 Tw 10 0 0 10 42.5197 420.3799 Tm (\221 \027\024\016\002\030\016 2020 \020. \023\024)Tj /Span<>> BDC ( )Tj EMC (\017\033\035\034 2022 \020. \r)Tj /Span<>> BDC ( )Tj EMC (\205\206\207\211 \253\203\204\222\037 \022\024\035\024)Tj 0 Tw (-)Tj 0.142 Tw T* (\023\030\024\022\021\024\035\024\020\017\017 \017\n\036\027\017 \202.\203\ . \217\t\032\017\b\273 \204\017\027\007\030\026\r\026 \217\024\f\f\017\017\ )Tj 0.082 Tw T* (\002\t\035\024 \023\030\024\r\036\007\036\027\024 \023\030\024\f\023\036\ \022\021\017\r\027\024\036 \030\026\027\007\024\n\017\017\030\024\r\026\ \027\027\024\036 )Tj 0.279 Tw T* (\022\035\017\027\017\004\036\f\022\024\036 \017\f\f\035\036\007\024\r\026\ \027\017\036, \r)Tj /Span<>> BDC ( )Tj EMC (\022\024\021\024\030\024\036 \002\t\035\024 \r\022\035\033)Tj 0 Tw (-)Tj 0.348 Tw T* (\004\036\027\024 103 \023\026\006\017\036\027\021\026 \f)Tj /Span<>> BDC ( )Tj EMC [(\007\024\002\030\024\022\026\004\036\f\021\r\036\027\027\t\n\017 )0.5(\220\023\017\021\036)]TJ 0 Tw (-)Tj 0.429 Tw T* (\035\017\026\035\034\027\t\n\017 \027\024\r\024\024\002\030\026\024\r\026\ \027\017\016\n\017 \024\002\024\007\024\004\027\024\005 \022\017\001\022\ \017 )Tj 0.099 Tw T* (\030\026\n\036\030\024\n \024\021 20 \007\024)Tj /Span<>> BDC ( )Tj EMC (30 \n\n \002\036 \220\027\007\024\f\022\024\023\017\004\036\f\022\017\b\ \023\030\017)Tj 0 Tw (-)Tj 0.081 Tw T* (\027\026\022\024\r \n\026\035\017\020\027\017\026\006\017\017, \f)Tj /Span<>> BDC ( )Tj EMC (\016\n\024\004\027\t\n \030\017\f\031\027\022\024\n \024\023\031\b\024\035\ \017, )Tj 0.065 Tw T* (\f\024\024\021\r\036\021\f\021\r\031\033\013\017\n \021\017\023\026\n II\ Is, IIIL, IV \023\024)Tj /Span<>> BDC ( )Tj EMC (\022\035\026\f\f\017\235\017\022\026)Tj 0 Tw (-)Tj 0.048 Tw T* [(\006\017\017 K)25(ud)-16(o)]TJ /Span<>> BDC ( )Tj EMC (S. \017)Tj /Span<>> BDC ( )Tj EMC (II-O \021\017\023\031 \023\024)Tj /Span<>> BDC ( )Tj EMC [(\022\035\026\f\f\017\235\017\022\026\006\017\017 Kimur)-33(a)]TJ /Span<>> BDC ( )Tj EMC (T., )Tj 0.033 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\f\024\f\031\007\017\f\021\t\n \030\017\f\031\027\022\024\n)Tj /Span<>> BDC ( )Tj EMC (\227 I \017)Tj /Span<>> BDC ( )Tj EMC (II \021\017\023 \023\024)Tj /Span<>> BDC ( )Tj EMC (Sano)Tj /Span<>> BDC ( )Tj EMC (Y. \200)Tj /Span<>> BDC ( )Tj EMC (\017\f)Tj 0 Tw (-)Tj 0.044 Tw T* (\f\035\036\007\024\r\026\027\017\036 \027\036 \r\022\035\033\004\026\035\ \017 \023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\027\024\r\024\024\002\030\026\024\r\026)Tj 0 Tw (-)Tj 0.19 Tw T* (\027\017\016\n\017, \031)Tj /Span<>> BDC ( )Tj EMC (\022\024\021\024\030\t\b \016\n\024\004\027\t\005 \030\017\f\031\027\024\ \022 \f\024\024\021\r\036\021\f\021\r\024\r\026\035 )Tj 0.049 Tw T* [(V)-15(i-V)56(n \021\017\023\031 \023\024)]TJ /Span<>> BDC ( )Tj EMC [(K)25(ud)-16(o S., \026)]TJ /Span<>> BDC ( )Tj EMC (\f\024\f\031\007\017\f\021\t\005)Tj /Span<>> BDC ( )Tj EMC (\227 IIIa-IIIb \021\017\023\031 )Tj 0.026 Tw T* (\023\024)Tj /Span<>> BDC ( )Tj EMC (Sano Y., \026)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\032\036 \002\024\035\034\027\t\036 \f)Tj /Span<>> BDC ( )Tj EMC (\f\036\n\036\005\027\t\n \026\007\036\027\024\n\026\021\024)Tj 0 Tw (-)Tj 0.283 Tw T* [(\027\t\n \023\024\035\017\023\024\027\t\n )0.5(\f\017\027\007\030\024\n\024\n, \030\036\006\017\007\017\r\027\t\n\017 \024\ \023\031\b\024)]TJ 0 Tw (-)Tj 0.121 Tw T* (\035\016\n\017 \021\024\035\f\021\024\005 \022\017\001\022\017. \222)Tj /Span<>> BDC ( )Tj EMC (\017\f\f\035\036\007\024\r\026\027\017\016 \017\f\022\035\033\004\026\035\ \017\f\034 )Tj 0.143 Tw T* (\002\024\035\034\027\t\036 \f)Tj /Span<>> BDC ( )Tj EMC (\027\024\r\024\024\002\030\026\024\r\026\027\017\016\n\017, \031)Tj /Span<>> BDC ( )Tj EMC (\022\024\021\024\030\t\b \r\024 \r\030\036\n\016 )Tj 0.459 Tw T* (\220\027\007\024\f\022\024\023\017\004\036\f\022\024\020\024 \r\n\036\001\ \026\021\036\035\034\f\021\r\026 \027\026\002\035\033\007\026\035\f\016 \ \027\036)Tj 0 Tw (-)Tj 0.328 Tw T* (\023\024\035\027\t\005 \035\017\235\021\017\027\020 \024\023\031\b\024\035\ \017 \017\035\017 \036\020\024 \024\021\f\031\021\f\021\r\017\036 [5]. )Tj 0.113 Tw T* (\222\f\f\035\036\007\024\r\026\027\017\036 \002\t\035\024 \024\007\024\002\ \030\036\027\024 \035\024\022\026\035\034\027\t\n \220\021\017\004\036\f\ \022\017\n )Tj 0.494 Tw T* [(\022\024\n\017\021\036\021\024\n \205\206\207\211 )0.5(\253\203\204\222\037 \022\024\035\024\023\030\024\022\021\024\035\024\020\ \017\017 \017\n\036\027\017 )]TJ 0.065 Tw T* (\202.\203.)Tj /Span<>> BDC ( )Tj EMC 2.054 0 Td [(\217\t\032\017\b\273 )0.6(\204\017\027\007\030\026\r\026 )0.5(\217\024\f\f\017\017, )0.6(\023\030\024\021\024\022\024\035 )0.5(\22510 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 18.814 0 Td (\026)Tj 0 Tw (-)Tj 0.254 Tw -20.868 -1.218 Td (\030\036\020\017\f\021\030\017\030\024\r\026\027\024 \027\026)Tj /Span<>> BDC ( )Tj EMC [(\f\026\005\021\036 \253cl)-30.9(inical)56(tr)-37(ials.gov\273 \(\030\036\020\017)]TJ 0 Tw (-)Tj T* (\f\021\030\026\006\017\024\027\027\t\005 \027\024\n\036\030 NCT05690490\)\ .)Tj -0.099 Tw T* (\217\026\f\023\030\036\007\036\035\036\027\017\036 \023\026\006\017\036\027\ \021\024\r \023\024)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\026\n \024\f\031\013\036\f\021\r\035\016\035\024\f\034\ )Tj 0.188 Tw T* [(\017\027\021\030\026\024\023\036\030\026\006\017\024\027\027\024 )0.5(\023\030\017)]TJ /Span<>> BDC ( )Tj EMC (\023\024\n\024\013\017 \020\036\027\036\030\026\021\024\030\026 \f\035\031\ \004\026\005)Tj 0 Tw (-)Tj 0.023 Tw T* (\027\t\b \004\017\f\036\035 \027\026)Tj /Span<>> BDC ( )Tj EMC [(\f\026\005\021\036 r)-32.9(and)-16(omizer.or)-32(g. \224\027\007\024\f\022\024\023\017\004\036\f\022\026\016 )]TJ 0.87 Tw T* (\023\024\007\f\035\017\017\f\021\026\016 \007\017\f\f\036\022\006\017\016\ \002\t\035\026 \r\t\023\024\035\027\036\027\026 51, )Tj 0.404 Tw 23.244 48.712 Td (\026)Tj /Span<>> BDC ( )Tj EMC (\220\027\007\024\f\022\024\023\017\004\036\f\022\026\016 \030\036\036\022\ \006\017\016 \f\035\017\017\f\021\024\005 \024\002\024\035\024\004\022\017\ )Tj 0 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\006\017\030\022\031\035\016\030\027\t\n \030\026\030\036\024\n)Tj /Span<>> BDC ( )Tj EMC (\227 52 \002\024\035\034\027\t\n.)Tj 0.313 Tw T* (\221\021\026\021\017\f\021\017\004\036\f\022\017 \027\026\004\017\n\024\ \005 \030\026\027\017\006\t \n\036\032\007\031 \020\030\031\023\023\026\ \n\017 )Tj 0.305 Tw T* (\023\024)Tj /Span<>> BDC ( )Tj EMC (\r\024\030\026\f\021\031, \023\024\035\031, \035\024\022\026\035\017\026\ \006\017\017 \017)Tj /Span<>> BDC ( )Tj EMC (\030\026\n\036\030\031 \024\023\031\b\024)Tj 0 Tw (-)Tj 0.34 Tw T* [(\035\017 \r\t\016\r\035\036\027\024 \027\036 \002\t\035\024. )0.5(\204\036\007\017\026\027\026 )0.5(\030\026\n\036\030\026 \027\024\r\024\024\002)]TJ 0 Tw (-)Tj 0.407 Tw T* (\030\026\024\r\026\027\017\005 \024\002\024\007\024\004\027\024\005 \022\ \017\001\022\017 \f\024\f\021\026\r\017\035\026 \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 )Tj 0.183 Tw T* [(C-EMR )0.5(24 )0.5(\(20\22627\) \n\n, )0.5(\026)]TJ /Span<>> BDC ( )Tj EMC 10.66 0 Td [(\r )0.5(\020\030\031\023\023\036 )0.5(ESD)]TJ /Span<>> BDC ( )Tj EMC [(\227 )0.5(25 )0.5(\(21,5\226)]TJ 0.262 Tw -10.66 -1.218 Td (30\))Tj /Span<>> BDC ( )Tj EMC (\n\n. \200)Tj /Span<>> BDC ( )Tj EMC (\026\027\026\035\017\017\030\031\036\n\t\b \020\030\031\023\023\026\b \024\ \023\031\b\024\035\017 \030\026\f\023\024)Tj 0 Tw (-)Tj 0.19 Tw T* (\035\026\020\026\035\017\f\034, \023\030\036\017\n\031\013\036\f\021\r\036\ \027\027\024, \r)Tj /Span<>> BDC ( )Tj EMC (\023\030\026\r\t\b \024\021\007\036\035\026\b \024\002\024)Tj 0 Tw (-)Tj 0.167 Tw T* (\007\024\004\027\024\005 \022\017\001\022\017)Tj /Span<>> BDC ( )Tj EMC (\227 \r)Tj /Span<>> BDC ( )Tj EMC (38)Tj /Span<>> BDC ( )Tj EMC (\(73,1%\) \f\035\031\004\026\016\b \r)Tj /Span<>> BDC ( )Tj EMC (\024\f\027\024\r\027\024\005 )Tj 0 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\r)Tj /Span<>> BDC ( )Tj EMC (40)Tj /Span<>> BDC ( )Tj EMC (\(78,4%\))Tj /Span<>> BDC ( )Tj EMC (\227 \r)Tj /Span<>> BDC ( )Tj EMC (\022\024\027\021\030\024\035\034\027\024\005 \020\030\031\023\023\036 \(\ \230\026\002\035.)Tj /Span<>> BDC ( )Tj EMC (1\).)Tj 0.107 Tw T* [(\212\035\016 \024\023\017\f\026\027\017\016 \n\026\022\030\024\f\022\024\ \023\017\004\036\f\022\024\020\024 )0.5(\f\021\030\024\036\027\017\016 \024\023\031\b\024\035\017 )]TJ 0.189 Tw T* [(\017\f\023\024\035\034\024\r\026\035\017\f\034 )0.5(\215\026\030\017\032\f\022\026\016 \017)]TJ /Span<>> BDC ( )Tj EMC (\023\030\026\020\n\026\021\017\004\036\f\022\026\016 \022\035\026\f)Tj 0 Tw (-)Tj 0.256 Tw T* (\f\017\235\017\022\026\006\017\017 [13,14]. \210\006\036\027\022\026 \023\ \024\r\036\030\b\027\024\f\021\027\024\020\024 \030\017\f\031\027)Tj 0 Tw (-)Tj 0.226 Tw T* (\022\026 \024\023\031\b\024\035\017 \023\030\024\r\024\007\017\035\026\f\ \034 \f\024\020\035\026\f\027\024 \022\035\026\f\f\017\235\017\022\026\006\ \017\016\n )Tj 0.005 Tw T* [(K)25(ud)-16(o)]TJ /Span<>> BDC ( )Tj EMC (S. \017)Tj /Span<>> BDC ( )Tj EMC (Sano)Tj /Span<>> BDC ( )Tj EMC (Y., \026)Tj /Span<>> BDC ( )Tj EMC (\r \024\021\027\024\001\036\027\017\017 \b\026\030\026\022\021\036\030\017\ \f\021\017\022\017 \031\002)Tj 0 Tw (-)Tj -0.043 Tw T* (\004\026\021\t\b \027\024\r\024\024\002\030\026\024\r\026\027\017\005 \017\ \f\023\024\035\034\024\r\026\035\026\f\034 \022\035\026\f\f\017\235\017\ \022\026)Tj 0 Tw (-)Tj T* [(\006\017\016 Kimur)-32.9(a T. [15\22617].)]TJ 0.035 Tw T* (\207\t\035\024 \024\021\n\036\004\036\027\024, \004\021\024 \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 ESD \027\036\f\022\024\035\034\022\024 \004\026\ \013\036 \027\026)Tj 0 Tw (-)Tj 0.247 Tw T* (\002\035\033\007\026\035\f\016 \023\035\024\f\022\024-\023\030\017\023\024\ \007\027\016\021\t\005 \035\026\021\036\030\026\035\034\027\024 \030\026\ \f\023\030\024)Tj 0 Tw (-)Tj 0.074 Tw T* [(\f\021\030\026\027\016\033\013\017\005\f\016 )0.6(\027\036\020\030\026\027\031\035\016\030\027\t\005 )0.6(\021\017\023 )0.5(\027\024\r\024\024\002\030\026\024\r\026\027\017\005 )]TJ 0.355 Tw T* [(\f\024\020\035\026\f\027\024 \023\030\026\020\n\026\021\017\004\036\f\022\ \024\005 \022\035\026\f\f\017\235\017\022\026\006\017\017 \(LS)-21(T-NG-)]TJ 0.195 Tw T* (FE\), \026)Tj /Span<>> BDC ( )Tj EMC (\r C-EMR)Tj /Span<>> BDC ( )Tj EMC (\227 \035\026\021\036\030\026\035\034\027\024 \030\026\f\023\030\024\f\021\ \030\026\027\016\033\013\017\005\f\016 )Tj 0.181 Tw T* [(\020\030\026\027\031\035\016\030\027\t\005 )0.5(\020\024\n\024\020\036\027\027\t\005 \021\017\023 \(LS)-21(T-GH\). \221\024\f\031\007\017\f\021\t\005 )]TJ 0.131 Tw T* [(\030\017\f\031\027\024\022 \023\024\r\036\030\b\027\024\f\021\017 )0.5(\024\023\031\b\024\035\017 )0.5(II)]TJ /Span<>> BDC ( )Tj EMC [(\021\017\023\026 )0.5(\023\024)]TJ /Span<>> BDC ( )Tj EMC 17.783 0 Td (\022\035\026\f\f\017\235\017)Tj 0 Tw (-)Tj 0.161 Tw -17.783 -1.218 Td [(\022\026\006\017\017 )0.5(San\024 )0.5(Y. )0.6(\002\t\035 )0.5(\023\030\036\024\002\035\026\007\026\033\013\017\n )0.6(\r)]TJ /Span<>> BDC ( )Tj EMC 16.435 0 Td [(\020\030\031\023\023\036 )0.5(C-EMR )]TJ 0.052 Tw -16.435 -1.218 Td (\017)Tj /Span<>> BDC ( )Tj EMC (ESD)Tj /Span<>> BDC ( )Tj EMC (\227 \r)Tj /Span<>> BDC ( )Tj EMC (43)Tj /Span<>> BDC ( )Tj EMC (\(82,7%\) \017)Tj /Span<>> BDC ( )Tj EMC (34)Tj /Span<>> BDC ( )Tj EMC (\(66,7%\) \f\035\031\004\026\016\b, \f\024\024\021\r\036\021)Tj 0 Tw (-)Tj T* (\f\021\r\036\027\027\024 \(\230\026\002\035.)Tj /Span<>> BDC ( )Tj EMC (2\).)Tj 0.328 Tw T* (\200\f\036 \024\023\036\030\026\021\017\r\027\t\036 \r\n\036\001\026\021\ \036\035\034\f\021\r\026 \023\030\024\r\024\007\017\035\017\f\034 \023\024\ \007 )Tj 0.576 Tw T* [(\r\027\031\021\030\017\r\036\027\027\024\005 )0.5(\f\036\007\026\006\017\036\005. \215\030\017)]TJ /Span<>> BDC ( )Tj EMC (\031\007\026\035\036\027\017\017 \024\023\031\b\024\035\017 )Tj 0.197 Tw T* (\021\024\035\f\021\024\005 \022\017\001\022\017 \n\036\021\024\007\024\n\ \220\027\007\024\f\022\024\023\017\004\036\f\022\024\005 \030\036\036\022\ \006\017\017 )Tj 0.065 Tw T* (\f\035\017\017\f\021\024\005 \024\002\024\035\024\004\022\017 \f)Tj /Span<>> BDC ( )Tj EMC (\006\017\030\022\031\035\016\030\027\t\n \030\026\030\036\024\n, \026)Tj /Span<>> BDC ( )Tj EMC (\021\026\022)Tj 0 Tw (-)Tj 0.289 Tw T* (\032\036 ESD, \023\036\030\r\t\n \220\021\026\023\024\n \f\024\007\026\r\ \026\035\026\f\034 \023\024\007\f\035\017\017\f\021\026\016 )Tj 0.057 Tw T* (\253\023\024\007\031\001\022\026\273 \023\031\021\036\n \017\027\255\036\ \022\006\017\017 \r)Tj /Span<>> BDC ( )Tj EMC (\f\021\036\027\022\031 \022\017\001\022\017 \030\026\f\021\r\024\030\026\ )Tj 0.22 Tw T* [(\020\036\035\024\235\031\017\027\026, )0.6(\024\022\030\026\001\036\027\027\024\020\024 )0.5(\017\027\007\017\020\024\022\026\030\n\017\027\024\n. )0.5(\210\006\036\027\022\026 )]TJ 0.329 Tw T* (\035\017\235\021\017\027\020\026 \023\030\024\r\024\007\017\035\026\f\034\ \027\026)Tj /Span<>> BDC ( )Tj EMC (\024\f\027\024\r\026\027\017\017 \022\035\026\f\f\017\235\017\022\026)Tj 0 Tw (-)Tj 0.022 Tw T* [(\006\017\017 K)-16(a)15(t)17(o)]TJ /Span<>> BDC ( )Tj EMC (H. [18]. \200)Tj /Span<>> BDC ( )Tj EMC [(\f\035\031\004\026\036 )0.5(\023\024\035\027\024\020\024 \035\017\235\021\017\027\020\026 )0.5(\(1,2 \021\017\023 )]TJ 0.094 Tw T* (\023\024)Tj /Span<>> BDC ( )Tj EMC [(K)-16(a)15(t)17(o)]TJ /Span<>> BDC ( )Tj EMC (H.\), \r)Tj /Span<>> BDC ( )Tj EMC (\024\f\027\024\r\027\024\005 \020\030\031\023\023\036 \f)Tj /Span<>> BDC ( )Tj EMC (\023\024\n\024\013\034\033 \220\027\007\024\f\022\024)Tj 0 Tw (-)Tj 0.09 Tw T* [(\023\017\004\036\f\022\024\020\024 \027\024\032\026 \024\f\031\013\036\f\ \021\r\035\016\035\f\016 )0.5(\006\017\030\022\031\035\016\030\027\t\005 \030\026\030\036 )]TJ 0.213 Tw T* (\f\035\017\017\f\021\024\005 \024\002\024\035\024\004\022\017 \r\024\022\ \030\031\020 \027\024\r\024\024\002\030\026\024\r\026\027\017\016 \f)Tj /Span<>> BDC ( )Tj EMC (\024\021)Tj 0 Tw (-)Tj -0.012 Tw T* (\f\021\031\023\024\n \024\021 \027\036\020\024 \027\026)Tj /Span<>> BDC ( )Tj EMC (2\2263)Tj /Span<>> BDC ( )Tj EMC (\n\n \007\035\016 \007\024\f\021\017\032\036\027\017\016 \027\036\020\026\ \021\017\r\027\024\005 )Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0 Tw 9 0 0 9 42.5197 730.483 Tm (\020\004\206\f\t\204\004 1.)Tj 0 0 0 1 k /GS1 gs /T1_4 1 Tf ( \255\005\211\026\002 \004\026\032\026\013\024\031\032\025\t\024\025\013\ \026 \005\n\023\022\021\020\004 \025)Tj /Span<>> BDC ( )Tj EMC [(\205\030\026\023\031\021\021\020\004 \021\n\027\n\n\005\032\026\016\n\027\ )0.5(\026\021\025\017 \027)]TJ /Span<>> BDC ( )Tj EMC (\025\t\t\023\031\030\205\031\003\020\004 \202\032\205\033\033\026\004)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0 -1.2 TD [(T)48(able 1)47(.)]TJ 0 0 0 1 k /GS1 gs /T1_4 1 Tf [( General character)-36.8(istics of patients and remov)13.3(ed neoplas)33(ms)]TJ ET 0 0 0 1 K 0.5 w /GS2 gs q 1 0 0 1 42.5197 715.181 cm 0 0 m 164.659 0 l S Q q 1 0 0 1 42.7697 694.3618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 207.1791 715.181 cm 0 0 m 96.378 0 l S Q q 1 0 0 1 207.1791 694.3618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 303.5571 715.181 cm 0 0 m 96.378 0 l S Q q 1 0 0 1 303.5571 694.3618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 399.935 715.181 cm 0 0 m 96.628 0 l S Q q 1 0 0 1 399.935 694.3618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 496.313 694.3618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 42.5197 694.1118 cm 0 0 m 164.659 0 l S Q q 1 0 0 1 42.7697 682.9005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 207.1791 694.1118 cm 0 0 m 96.378 0 l S Q q 1 0 0 1 207.1791 682.9005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 303.5571 694.1118 cm 0 0 m 96.378 0 l S Q q 1 0 0 1 303.5571 682.9005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 399.935 694.1118 cm 0 0 m 96.628 0 l S Q q 1 0 0 1 399.935 682.9005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 682.9005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 682.6505 cm 0 0 m 164.659 0 l S Q q 1 0 0 1 42.7697 671.4392 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 207.1791 682.6505 cm 0 0 m 96.378 0 l S Q q 1 0 0 1 303.5571 682.6505 cm 0 0 m 96.378 0 l S Q q 1 0 0 1 399.935 682.6505 cm 0 0 m 96.628 0 l S Q q 1 0 0 1 496.313 671.4392 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 671.1892 cm 0 0 m 164.659 0 l S Q q 1 0 0 1 42.7697 659.9779 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 207.1791 671.1892 cm 0 0 m 96.378 0 l S Q q 1 0 0 1 207.1791 659.9779 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 303.5571 671.1892 cm 0 0 m 96.378 0 l S Q q 1 0 0 1 303.5571 659.9779 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 399.935 671.1892 cm 0 0 m 96.628 0 l S Q q 1 0 0 1 399.935 659.9779 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 659.7279 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 42.5197 659.7279 cm 0 0 m 164.659 0 l S Q q 1 0 0 1 42.7697 648.5166 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 207.1791 659.7279 cm 0 0 m 96.378 0 l S Q q 1 0 0 1 207.1791 648.5166 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 303.5571 659.7279 cm 0 0 m 96.628 0 l S Q q 1 0 0 1 303.5571 648.5166 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 399.935 648.5166 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 648.5166 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 42.5197 648.2666 cm 0 0 m 164.659 0 l S Q q 1 0 0 1 42.7697 637.0554 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 207.1791 648.2666 cm 0 0 m 96.378 0 l S Q q 1 0 0 1 303.5571 648.2666 cm 0 0 m 96.378 0 l S Q q 1 0 0 1 399.935 648.2666 cm 0 0 m 96.628 0 l S Q q 1 0 0 1 496.313 637.0554 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 636.8054 cm 0 0 m 164.659 0 l S Q q 1 0 0 1 42.7697 625.5941 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 207.1791 636.8054 cm 0 0 m 96.378 0 l S Q q 1 0 0 1 207.1791 625.5941 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 303.5571 636.8054 cm 0 0 m 96.378 0 l S Q q 1 0 0 1 303.5571 625.5941 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 399.935 636.8054 cm 0 0 m 96.628 0 l S Q q 1 0 0 1 399.935 625.5941 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 625.5941 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 625.3441 cm 0 0 m 164.659 0 l S Q q 1 0 0 1 42.7697 614.1328 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 207.1791 625.3441 cm 0 0 m 96.378 0 l S Q q 1 0 0 1 207.1791 614.1328 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 303.5571 625.3441 cm 0 0 m 96.378 0 l S Q q 1 0 0 1 303.5571 614.1328 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 399.935 625.3441 cm 0 0 m 96.628 0 l S Q q 1 0 0 1 399.935 614.1328 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 614.1328 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 613.8828 cm 0 0 m 164.659 0 l S Q q 1 0 0 1 42.7697 602.6715 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 207.1791 613.8828 cm 0 0 m 96.378 0 l S Q q 1 0 0 1 207.1791 602.6715 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 303.5571 613.8828 cm 0 0 m 96.378 0 l S Q q 1 0 0 1 303.5571 602.6715 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 399.935 613.8828 cm 0 0 m 96.628 0 l S Q q 1 0 0 1 399.935 602.6715 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 602.6715 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 602.4215 cm 0 0 m 164.659 0 l S Q q 1 0 0 1 207.1791 602.4215 cm 0 0 m 96.378 0 l S Q q 1 0 0 1 303.5571 602.4215 cm 0 0 m 96.378 0 l S Q q 1 0 0 1 399.935 602.4215 cm 0 0 m 96.628 0 l S Q BT /GS1 gs /T1_3 1 Tf 8 0 0 8 108.2347 701.7464 Tm (\200\004\006\004\214\r\003\006)Tj 17.075 0.6 Td (C-EMR)Tj -0.453 -1.2 Td (\()Tj /T1_5 1 Tf (n)Tj /T1_3 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (52\))Tj 13.026 1.2 Td (ESD)Tj -0.979 -1.2 Td (\()Tj /T1_5 1 Tf (n)Tj /T1_3 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (51\))Tj /T1_5 1 Tf 13.558 0.6 Td (p)Tj /T1_1 1 Tf -50.055 -2.033 Td (\200\024\030\026\f\021 \(\n\036\007\017\026\027\026\), \035\036\021)Tj 23.956 0 Td (63)Tj /Span<>> BDC ( )Tj EMC (\(52\22670\))Tj 12.047 0 Td (61)Tj /Span<>> BDC ( )Tj EMC (\(56\22668\))Tj 12.969 0 Td (0,5***)Tj -48.972 -1.433 Td (\215\024\035)Tj 0 -1.433 TD (\204\031\032\f\022\024\005)Tj 24.012 0 Td (22)Tj /Span<>> BDC ( )Tj EMC (\(42,3%\))Tj 12.047 0 Td (28)Tj /Span<>> BDC ( )Tj EMC (\(54,9%\))Tj 13.163 0 Td (0,2**)Tj -49.222 -1.433 Td (\240\036\027\f\022\017\005)Tj 24.012 0 Td (30)Tj /Span<>> BDC ( )Tj EMC (\(57,7%\))Tj 12.047 0 Td (23)Tj /Span<>> BDC ( )Tj EMC (\(45,1%\))Tj -36.059 -1.433 Td (\214\024\022\026\035\017\026\006\017\016 \024\023\031\b\024\035\017 \r)Tj /Span<>> BDC ( )Tj EMC (\024\002\024\007\024\004\027\024\005 \022\017\001\022\036)Tj 0 -1.433 TD (\215\030\026\r\t\036 \024\021\007\036\035\t)Tj 24.012 0 Td (38)Tj /Span<>> BDC ( )Tj EMC (\(73,1%\))Tj 12.047 0 Td (40)Tj /Span<>> BDC ( )Tj EMC (\(78,4%\))Tj 13.163 0 Td (0,5**)Tj -49.222 -1.433 Td (\214\036\r\t\036 \024\021\007\036\035\t)Tj 24.012 0 Td (14)Tj /Span<>> BDC ( )Tj EMC (\(26,9%\))Tj 12.047 0 Td (11)Tj /Span<>> BDC ( )Tj EMC (\(21,6%\))Tj 13.163 0 Td (0,5**)Tj -49.222 -1.433 Td (\204\036\007\017\026\027\026 \030\026\n\036\030\026 \024\023\031\b\024\035\ \017 \(\022\r\026\030\021\017\035\017\), \n\n)Tj 23.613 0 Td (24)Tj /Span<>> BDC ( )Tj EMC (\(20\22627,5\))Tj 12.047 0 Td (25)Tj /Span<>> BDC ( )Tj EMC (\(21,5\22630\))Tj 13.312 0 Td (0,2***)Tj /T1_4 1 Tf 7 0 0 7 42.5197 590.9369 Tm (\032\025\003\031\006\026\021\025\031: \032*)Tj /Span<>> BDC ( )Tj EMC (\227 \024\n\006\021\020\017 \013\032\025\024\031\032\025\017 \225\025\001\ \031\032\026; \032**)Tj /Span<>> BDC ( )Tj EMC (\227 \013\032\025\024\031\032\025\017 \232)Tj 4.081 0 0 4.081 233.7775 593.2679 Tm (2)Tj 7 0 0 7 235.818 590.9369 Tm (; \032***)Tj /Span<>> BDC ( )Tj EMC [(\227 \013\032\025\024\031\032\025\017 \240\026\021\021\026\226\214)50(\025\024\021\025)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\033\030\031\030\213\b)-20.9(\035\231\213\233\t \021\032)50(\b)42(\032\231\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj /T1_6 1 Tf 25 0 0 25 512.8145 56.0378 Tm (23)Tj ET endstream endobj 2476 0 obj <>stream q /GS0 gs /Fm0 Do Q 0 0 0 1 K 1 j 1 J [0 2.997]0 d /GS1 gs q 1 0 0 1 74.3631 540.8533 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 71.3661 540.8533 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q [0 2.997]0 d q 1 0 0 1 74.3631 503.6455 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 71.3661 503.6455 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q 0 j 0 J q 1 0 0 1 70.8661 449.5764 cm 0 0 m 453.543 0 l S Q BT 0 0 0 1 k /T1_0 1 Tf 0.105 Tw 9 0 0 9 119.0551 730.4919 Tm [(AIM: )0.5(to )0.5(com)16(pare )0.5(the early )0.6(and late )0.5(results )0.5(of )0.5(endoscopic )0.6(mucosal )0.5(resection )0.5(with )0.5(a )0.5(circular incision )0.5(\(C-EMR\) and )]TJ 0.023 Tw 0 -1.111 TD [(endoscopic submucosal dissection \(ESD\) for larg)12(e benign epithelial neoplas)33(ms of the colon.)]TJ 0.024 Tw T* [(P)45(A)45(TIENT)-9.9(S A)53(ND METHODS: a p)46(rospectiv)13(e randomized com)16(parativ)13(e study \(N)17(ov)13(ember 2020 to July 2022\) included 103 )]TJ 0.026 Tw T* [(patients )0.6(with )0.5(benign )0.6(epithelial )0.6(neoplas)33.1(ms )0.5(of )0.6(the )0.5(colon )0.6(20\22630)]TJ /Span<>> BDC ( )Tj EMC 24.352 0 Td [(mm )0.6(sized. )0.5(The )0.5(C-EMR )0.5(method )0.5(w)13(as )0.6(used )0.5(in )0.6(52, )0.5(ESD)]TJ /Span<>> BDC ( )Tj EMC 19.687 0 Td (\227 )Tj 0.023 Tw -44.039 -1.111 Td (51 patients.)Tj -0.056 Tw 0 -1.111 TD [(RESUL)30(T)-10(S: the remov)16(al of the tumor by the C-EMR req)14(uired signif)-42.9(icantly less time, com)16(pared with the ESD method)]TJ /Span<>> BDC ( )Tj EMC (\227 30 )Tj -0.02 Tw 0 -1.111 TD [(and 60 minutes, respectiv)13.1(ely \(p)]TJ /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC [(0.001\). Intra- and postoperativ)13.1(e com)16.1(plications occur)-16(red in 13 \(23.7%\) patients in )]TJ 0.004 Tw T* [(the C-EMR g)14(roup and in 12 \(23.5%\) patients in the ESD g)14(roup. The most freq)14(uently repor)-40(ted com)16(plication w)13(as post)]TJ 0 Tw (-)Tj 0.05 Tw T* [(coagulation syndrome in the main and control g)14(roups)]TJ /Span<>> BDC ( )Tj EMC [(\227 in 9 \(17.3%\) and 11 \(21.6%\) cases, respectiv)13(ely)32(. It w)13(as )]TJ 0.048 Tw T* [(found )0.5(that the dif)-39.9(f)-43(icult )0.5(location )0.5(of the )0.5(tumor \(OR)]TJ /Span<>> BDC ( )Tj EMC 20.005 0 Td (=)Tj /Span<>> BDC ( )Tj EMC [(18.3; )0.5(p)]TJ /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC [(0.01\) and )0.5(intraoperativ)13(e com)16(plications \(OR)]TJ /Span<>> BDC ( )Tj EMC 22.162 0 Td (=)Tj /Span<>> BDC ( )Tj EMC (37.5; )Tj 0.074 Tw -42.167 -1.111 Td (p)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC [(0.04\) are independent con)11(v)13(ersion factors of endoscopic inter)-41.9(v)13(ention. The incidence of tumor remov)16.1(al en bloc )]TJ 0.016 Tw T* [(and )0.5(neg)12(ativ)13(e )0.6(resection )0.5(margins )0.6(\(R0\) )0.5(in )0.5(the )0.6(main )0.5(and )0.5(control )0.6(g)14(roups )0.5(did )0.6(no)13(t )0.5(signif)-43(icantly )0.5(dif)-40(fer)]TJ /Span<>> BDC ( )Tj EMC 37.421 0 Td [(\227 )0.5(47)]TJ /Span<>> BDC ( )Tj EMC 2.497 0 Td [(\(90.4%\) )0.5(and )]TJ 0.023 Tw -39.918 -1.111 Td (49 \(96.1%\) \(p)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0.4\) and 40 \(76.9%\) and 45 \(88.2%\) \(p)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC [(0.2\), respectiv)13(ely)32(.)]TJ 0.075 Tw T* [(C)21(ON)22(CLUSION: )0.6(endoscopic )0.6(mucosal )0.6(resection )0.6(with )0.6(a )0.6(circumferential )0.7(incision )0.6(is )0.6(an )0.5(ef)-40(fectiv)13(e )0.6(and )0.5(safe )0.5(op)12.9(tion )0.5(com)16(pa)]TJ 0 Tw (-)Tj 0.028 Tw 0 -1.111 TD [(rable )0.6(to )0.5(endoscopic )0.5(submucosal )0.6(dissection, )0.5(and )0.6(can )0.5(be )0.6(the )0.5(method )0.6(of )0.5(choice )0.5(for )0.5(benign )0.5(epithelial )0.5(neoplas)33(ms )0.6(of )0.5(the )]TJ 0.023 Tw 0 -1.111 TD (colon sized 20\22630)Tj /Span<>> BDC ( )Tj EMC [(mm. The operation time of C-EMR is tw)12(o times less than ESD.)]TJ /T1_1 1 Tf 0.01 Tc -0.01 Tw 8 0 0 8 70.9061 565.2226 Tm [(KEYW)22(ORDS:)]TJ /T1_0 1 Tf 0 Tc 0.023 Tw 4.948 0 Td [( EMR, ESD, C-EMR, h)12(ybr)-37(id method, circular incision, epithelial neoplas)33(ms)]TJ /T1_1 1 Tf 0.01 Tc 0.018 Tw -4.948 -1.909 Td [(C)19(ONFL)-33(ICT)5( OF)5( INTE)25(REST)62(:)]TJ /T1_0 1 Tf 0 Tc 0.023 Tw 9.871 0 Td [( The authors declare no conf)-22(lict of interest)]TJ /T1_1 1 Tf 0.037 Tc 0.138 Tw -9.871 -2.617 Td [(F)3.2(O)-4.6(R)8.7( C)-17.5(I)-15.6(T)45.4(A)37.5(T)-24.5(I)-1.2(ON:)]TJ /T1_2 1 Tf 0.023 Tc 0.147 Tw 6.582 0 Td [( A)-28.4(b)-22.1(d)-8.9(u)-8.4(l)-54.5(z)-12.6(h)-8.3(a)-11.4(l)-16.7(i)-11(e)-15.8(v)-28.3(a)]TJ /Span<>> BDC ( )Tj EMC [(E)-5.6(.)10.8(U)9.9(.)-23.5(, L)-12.2(i)-6.6(k)-14.9(u)-16.3(t)-21.9(o)-10.3(v)]TJ /Span<>> BDC ( )Tj EMC [(A)-23(.)-23.9(A)-23(.)-23.5(, V)8.4(e)-22.8(s)-22.9(e)-18(l)-20.9(o)-10.3(v)]TJ /Span<>> BDC ( )Tj EMC [(V)39.7(.)40.6(V)39.7(.)-23.5(, M)-13.1(t)-48(v)-36.3(r)-30.8(a)-11.4(l)-37.8(a)-26.6(s)-8.8(h)-10.7(v)-51.8(i)-7.1(l)-16.7(i)]TJ /Span<>> BDC ( )Tj EMC [(D)16.4(.)-23.9(A)-23(.)-23.5(, Y)12.7(u)-8.4(g)-8(a)-15(i)]TJ /Span<>> BDC ( )Tj EMC [(O)11.4(.)-7.3(M)-7.1(.)-23.5(, K)-20.5(h)-10.9(o)-9.2(m)-15.4(y)-24.2(a)-11.2(k)-3.7(o)-10.3(v)]TJ /Span<>> BDC ( )Tj EMC [(E)-5.6(.)-23.9(A)-23(.)-23.5(, C)-16(h)-15(e)-12.1(r)-35.9(n)-14.9(y)-28.9(s)-8.8(h)-10.9(o)-10.3(v)]TJ /Span<>> BDC ( )Tj EMC [(S)-9.6(.)40.6(V)39.7(.)-23.5(,)23( )]TJ -0.013 Tw -6.587 -1.2 Td [(S)-12.1(u)-21.9(s)-8.8(h)-8.6(k)-3.7(o)-10.3(v)]TJ /Span<>> BDC ( )Tj EMC [(O)11.4(.)-9.8(I)-10.3(. E)-0.8(n)-14.6(d)-11.1(o)-15.8(s)-17.6(c)-6.6(o)-8.3(p)-18.6(i)-5(c m)-8(u)-6.5(c)-6.5(o)-15.8(s)-24.7(a)-11.4(l r)-19.1(e)-22.8(s)-22.9(e)-19.1(c)-41.5(t)-46.2(i)-6.8(o)-9.2(n w)-45.7(i)-15.8(t)-26.1(h a c)-38.2(i)-6(r)-11.7(c)-12.1(u)-7(m)-14(f)-28.4(e)-12.1(r)-19.1(e)-11.5(n)-17.3(t)-46.2(i)-5.1(a)-11.4(l i)-3.2(n)-10(c)-38.2(i)-7.4(s)-26.1(i)-6.8(o)-9.2(n i)-3.2(n t)-26.1(h)-15.1(e r)-19.1(e)-11.5(m)-12.4(o)-10.3(v)-28.4(a)-11.4(l o)-12.1(f c)-6.5(o)-15.6(l)-20.8(o)-9.3(n n)-16.1(e)-21.1(o)-8.3(p)-20.1(l)-37.7(a)-26.7(s)-6.5(m)-11.6(s)-15.5(. R)-6.7(e)-22.8(s)-8.8(u)-8.4(l)-15.4(t)-48.9(s o)-12.1(f a r)-30.8(a)-7.6(n)-14.5(d)-11.1(o)-9.2(m)]TJ 0 Tc 0 Tw 56.341 0 Td (-)Tj 0.023 Tc 0.024 Tw -56.341 -1.2 Td [(i)-8.3(z)-14(e)-21(d t)-30.8(r)-56.4(i)-5.1(a)-11.4(l)-31.7(. )]TJ /T1_0 1 Tf 0.033 Tc -0.033 Tw [(K)13.9(ol)3.6(op)2.4(r)3.1(o)3.5(k)-19.2(t)2.2(ol)3.6(o)-3.2(g)-13.2(i)6.7(a)5.8(.)]TJ /T1_2 1 Tf 0.023 Tc 0.024 Tw 11.617 0 Td [( 2)-8.9(0)-3.8(2)8.8(4)10.2(;)9.8(2)-10.3(3)6(\()37.7(1)44.3(\))14.5(:)2.3(21)26.4(\226)31.7(3)11.6(1)4.2(. \()-0.9(i)-3.2(n R)-6.5(u)-21.9(s)-22.3(s)-15.5(.)43.2(\))10.4(. )0.5(h)-17.2(t)-49.4(t)-29.4(p)-18.7(s)-8(:)1.9(/)84.7(/)36.4(d)-11.1(o)-12.5(i.)2.7(o)-11.8(r)-16.7(g)-22.8(/)11.2(1)14(0)6.5(.)-5.6(3)7.9(3)-15.9(8)1.3(7)4.6(8/)7.9(2)-8.9(0)9.3(7)-1.9(3)-13.3(-)41.2(7)10.7(55)-8.9(6)-26.7(-)9.7(2)-8.9(0)-3.8(2)8.7(4)-28.4(-)9.7(2)-10.3(3)-13.3(-)55.1(1)26.8(-)9.8(21)27(-)32.6(3)11.6(1)]TJ /T1_1 1 Tf 0.01 Tc 0.088 Tw -11.612 -2.617 Td [(\026\020\021\033\030)5( \020\036\017)5( \013\033\021\033\013\023\030\037\023:)]TJ /T1_0 1 Tf 0 Tc 0.093 Tw 10.717 0 Td ( \201\005\030\205\023\204\026\023\025\031\027\026 \230.\214., \225\210\213\ \214 \253\217\240\215\037 \013\n\023\n\033\032\n\013\024\n\023\n\202\025\ \025 \025\003\031\021\025 \201.\217.)Tj /Span<>> BDC ( )Tj EMC (\212\020\204\025\004\273 \240\025\021\016\030\032\026\027\026 \212\n\t\t\ \025\025, \205\023.)Tj /Span<>> BDC ( )Tj EMC (\207\026\023\002\003\026 \201\030\025\023\002, )Tj 0.023 Tw -10.722 -1.2 Td (\030.)Tj /Span<>> BDC ( )Tj EMC (2, \240\n\t\013\027\026, 123423, \212\n\t\t\025\002; e-mail: eabdulzhali\ eva@yandex.ru)Tj /T1_1 1 Tf 0.01 Tc 0.177 Tw 0.005 -1.2 Td [(ADDRESS)4.9( F)13(OR)4.9( C)19(ORRESPONDEN)23(CE:)]TJ /T1_0 1 Tf 0 Tc 0.182 Tw 14.369 0 Td [( A)12(bdulzhaliev)16.1(a E.U)36(., Ryzhikh N)18(ational Medical R)21(esearch Center of Colop)46(roctology)42(, Salyama Adilya st., 2, )]TJ 0.023 Tw -14.374 -1.2 Td [(Moscow)52(, 123423, R)22(ussia; e-mail: eabdulzhaliev)16.1(a@yande)-14.9(x.ru)]TJ 0 Tw 0 -2.792 TD (\200\026\024\026 \033\n\t\024\205\033\023\031\021\025\002)Tj /Span<>> BDC ( )Tj EMC (\227 18.09.2023)Tj /Span<>> BDC ( )Tj EMC 19.488 0 Td (\n\t\023\031 \030\n\032\026\005\n\024\013\025)Tj /Span<>> BDC ( )Tj EMC (\227 25.12.2023)Tj /Span<>> BDC ( )Tj EMC 18.78 0 Td (\032\025\021\002\024\n \013)Tj /Span<>> BDC ( )Tj EMC (\033\205\005\023\025\013\026\203\025\025)Tj /Span<>> BDC ( )Tj EMC (\227 12.02.2024)Tj ( )Tj -38.268 -1.375 Td (Received)Tj /Span<>> BDC ( )Tj EMC (\227 18.09.2023)Tj /Span<>> BDC ( )Tj EMC 19.488 0 Td (Revised)Tj /Span<>> BDC ( )Tj EMC (\227 25.12.2023)Tj /Span<>> BDC ( )Tj EMC 18.78 0 Td (Accepted for publication)Tj /Span<>> BDC ( )Tj EMC (\227 12.02.2024)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 70.936 383.8459 Tm (\023\023\034\226\034\022\031\034)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf 0 Tc 0.195 Tw 10 0 0 10 70.8661 359.4899 Tm [(\025\035\026\f\f\017\004\036\f\022\026\016 )0.6(\220\027\007\024\f\022\024\023\017\004\036\f\022\026\016 )0.6(\030\036\036\022\006\017\016 )0.5(\f\035\017\017\f\021\024\005 )]TJ 0.038 Tw 0 -1.218 TD [(\024\002\024\035\024\004\022\017 \(end)-16(oscopic mucosal r)-24(esec)-16(t)-32(ion, EMR\))]TJ /Span<>> BDC ( )Tj EMC (\227 \220\021\024 )Tj -0.059 Tw T* (\023\030\024\f\021\024\005 \017)Tj /Span<>> BDC ( )Tj EMC (\220\235\235\036\022\021\017\r\027\t\005 \n\036\021\024\007, \001\017\030\ \024\022\024 \017\f\023\024\035\034\031\036\n\t\005 )Tj 0.066 Tw T* (\r\024 \r\f\036\n \n\017\030\036 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\035\036\004\036\027\017\017 \002\024\035\034\027\t\b \f)Tj /Span<>> BDC ( )Tj EMC (\220\023\017\021\036\035\017\026\035\034\027\t)Tj 0 Tw (-)Tj 0.221 Tw T* (\n\017 \027\024\r\024\024\002\030\026\024\r\026\027\017\016\n\017 \021\024\ \035\f\021\024\005 \022\017\001\022\017 [1]. \210\007\027\026\022\024 )Tj 0.055 Tw T* (\023\030\017)Tj /Span<>> BDC ( )Tj EMC (\031\007\026\035\036\027\017\017 \024\023\031\b\024\035\036\005 \030\026\ \n\036\030\024\n \002\024\035\036\036 20 \n\n \n\036\021\024)Tj 0 Tw (-)Tj 0.114 Tw T* (\007\024\n EMR \004\026\f\021\024\021\026 \030\036\036\022\006\017\017 \ \036\007\017\027\t\n \002\035\024\022\024\n \023\030\024\020\030\036\f)Tj 0 Tw (-)Tj 0.03 Tw T* (\f\017\r\027\024 \f\027\017\032\026\036\021\f\016, \027\036\030\036\007\022\ \024 \023\024)Tj /Span<>> BDC ( )Tj EMC (\023\030\017\004\017\027\036 \235\030\026\020\n\036\027\021\026\006\017\017\ )Tj 0.07 Tw T* (\024\023\031\b\024\035\017, \022\024\021\024\030\026\016, \r)Tj /Span<>> BDC ( )Tj EMC (\022\024\027\036\004\027\024\n \f\004\036\021\036, \027\036\020\026\021\017\ \r\027\024 \024\021\030\026)Tj 0 Tw (-)Tj T* (\032\026\036\021\f\016 \027\026)Tj /Span<>> BDC ( )Tj EMC (\004\026\f\021\024\021\036 \035\024\022\026\035\034\027\t\b \030\036\006\ \017\007\017\r\024\r [2,3].)Tj 0.14 Tw T* (\222\f\b\024\007\016 \017)Tj /Span<>> BDC ( )Tj EMC (\024\f\027\024\r\027\024\020\024 \023\030\017\027\006\017\023\026 \030\026\ \007\017\022\026\035\034\027\024\020\024 \220\027\007\024)Tj 0 Tw (-)Tj 0.102 Tw T* (\f\022\024\023\017\004\036\f\022\024\020\024 \r\n\036\001\026\021\036\035\ \034\f\021\r\026, \022\024\021\024\030\t\005 \023\024\007\030\026\031\n\ \036\r\026)Tj 0 Tw (-)Tj 0.082 Tw T* (\036\021 \031\007\026\035\036\027\017\036 \024\023\031\b\024\035\017 \036\ \007\017\027\t\n \002\035\024\022\024\n \f)Tj /Span<>> BDC ( )Tj EMC (\007\024\f\021\017\032\036\027\017\036\n )Tj 0.149 Tw T* (\027\036\020\026\021\017\r\027\t\b \020\030\026\027\017\006 \030\036\036\ \022\006\017\017 \(R0\), \220\027\007\024\f\022\024\023\017\004\036\f\022\ \026\016 )Tj 0.123 Tw T* (\007\017\f\f\036\022\006\017\016 \r)Tj /Span<>> BDC ( )Tj EMC (\023\024\007\f\035\017\017\f\021\024\n \f\035\024\036 \r\f\036 \004\026\ \013\036 \017\f\023\024\035\034\031)Tj 0 Tw (-)Tj 0.353 Tw T* (\036\021\f\016 \007\035\016 \023\030\036\024\007\024\035\036\027\017\016\ \027\036\007\024\f\021\026\021\022\024\r \n\031\022\024\220\022\021\024\ \n\017\017. )Tj 0.074 Tw T* (\025)Tj /Span<>> BDC ( )Tj EMC (\021\024\n\031 \032\036, \027\036\n\026\035\024\r\026\032\027\t\n \026\f\ \023\036\022\021\024\n \016\r\035\016\036\021\f\016 \021\024\004\027\026\ \016 )Tj 0.115 Tw T* [(\020\017\f\021\024\035\024\020\017\004\036\f\022\026\016 )0.5(\024\006\036\027\022\026 \022\030\026\036\r \030\036\036\022\006\017\017\ \031\007\026\035\036\027\027\024\020\024 )]TJ 0.066 Tw T* [(\027\024\r\024\024\002\030\026\024\r\026\027\017\016, )0.6(\004\021\024 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 10.225 0 Td [(\f\035\031\004\026\036 \235\030\026\020\n\036\027\021\026\030\027\024\020\ \024 )0.6(\031\007\026)]TJ 0 Tw (-)Tj 0.284 Tw -10.225 -1.218 Td (\035\036\027\017\016 \024\023\031\b\024\035\017 \021\030\031\007\027\024\ \024\f\031\013\036\f\021\r\017\n\024 [4\2266]. \200\n\036\f\021\036 )Tj 0.163 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\021\036\n, \027\036\f\n\024\021\030\016 \027\026)Tj /Span<>> BDC ( )Tj EMC (\027\036\024\f\023\024\030\017\n\t\036 \023\030\036\017\n\031\013\036\f\021\ \r\026 \n\036)Tj 0 Tw (-)Tj 0.137 Tw T* (\021\024\007\017\022\017 \007\017\f\f\036\022\006\017\017 \r)Tj /Span<>> BDC ( )Tj EMC [(\023\024\007\f\035\017\017\f\021\024\n \f\035\024\036 \(end)-16(oscopic )]TJ 0.107 Tw T* [(submucosal dissec)-16(t)-32(ion, ESD\) \023\036\030\036\007 EMR \r)]TJ /Span<>> BDC ( )Tj EMC (\024\021\027\024\001\036\027\017\017 )Tj -0.06 Tw T* (\022\024\027\021\030\024\035\016 \020\030\026\027\017\006 \030\036\036\022\ \006\017\017, \007\026\027\027\t\005 \n\036\021\024\007 \017\n\036\036\021\ \002\024\035\036\036 )Tj 0.12 Tw 23.244 31.663 Td (\r\t\f\024\022\017\005 \030\017\f\022 \030\026\r\017\021\017\016 \023\036\ \030\235\024\030\026\006\017\017 \021\024\035\f\021\024\005 \022\017\001\ \022\017, )Tj 0.101 Tw T* (\021\030\036\002\031\036\021 \002\024\035\034\001\036 \024\023\036\030\026\ \006\017\024\027\027\024\020\024 \r\030\036\n\036\027\017 \017)Tj /Span<>> BDC ( )Tj EMC (\r\t\f\024\022\024\020\024 )Tj 0 Tw T* (\031\030\024\r\027\016 \022\r\026\035\017\235\017\022\026\006\017\017 \r\ \030\026\004\026-\220\027\007\024\f\022\024\023\017\f\021\026 [7,8].)Tj 0.154 Tw T* (\215\030\036\007\f\021\026\r\035\016\036\021\f\016, \004\021\024 \022\024\ \n\002\017\027\017\030\024\r\026\027\027\t\005 \n\036\021\024\007, \f\024\ \004\036)Tj 0 Tw (-)Tj -0.038 Tw T* (\021\026\033\013\017\005 \r)Tj /Span<>> BDC ( )Tj EMC (\f\036\002\036 \023\030\036\017\n\031\013\036\f\021\r\026 \024\007\027\024\ \005 \017)Tj /Span<>> BDC ( )Tj EMC (\007\030\031\020\024\005 \n\036\021\024\007\017\022 )Tj -0.013 Tw T* (\031\007\026\035\036\027\017\016 \027\024\r\024\024\002\030\026\024\r\026\ \027\017\005, \023\024\r\024\035\017\021 \023\030\036\024\007\024\035\036\ \021\034 \027\036)Tj 0 Tw (-)Tj 0.145 Tw T* (\007\024\f\021\026\021\022\017 \017)Tj /Span<>> BDC ( )Tj EMC (\007\024\f\021\017\004\034 \r\t\f\024\022\024\005 \004\026\f\021\024\021\ \t \030\036\036\022\006\017\017 \036\007\017)Tj 0 Tw (-)Tj 0.107 Tw T* (\027\t\n \002\035\024\022\024\n. \230\026\022, \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\r\t\023\024\035\027\036\027\017\017 \220\027\007\024\f\022\024\023\017\004\ \036\f\022\024\005 )Tj 0.235 Tw T* (\030\036\036\022\006\017\017 \f\035\017\017\f\021\024\005 \024\002\024\ \035\024\004\022\017 \f)Tj /Span<>> BDC ( )Tj EMC (\006\017\030\022\031\035\016\030\027\t\n \030\026)Tj 0 Tw (-)Tj 0.095 Tw T* [(\030\036\024\n \(end)-16(oscopic mucosal r)-24(esec)-16(t)-32(ion wi)-23.9(t)-13(h c)-24(ir)-32(cumfer)]TJ 0 Tw 21.758 0 Td (-)Tj 0.127 Tw -21.758 -1.218 Td [(ent)-32(ial inc)-24(ision, C-EMR\) \023\030\017)]TJ /Span<>> BDC ( )Tj EMC (\031\007\026\035\036\027\017\017 \220\023\017\021\036\035\017\026\035\034\ \027\t\b )Tj 0.032 Tw T* (\027\024\r\024\024\002\030\026\024\r\026\027\017\005, \r\036\007\031\013\ \031\033 \030\024\035\034 \r)Tj /Span<>> BDC ( )Tj EMC (\007\024\f\021\017\032\036\027\017\017 \027\036\020\026)Tj 0 Tw (-)Tj -0.017 Tw T* (\021\017\r\027\t\b \r)Tj /Span<>> BDC ( )Tj EMC (\024\021\027\024\001\036\027\017\017 \024\023\031\b\024\035\017 \020\030\ \026\027\017\006 \030\036\036\022\006\017\017 \017\020\030\026\036\021 \ )Tj 0.189 Tw T* (\006\017\030\022\031\035\016\030\027\t\005 \030\026\030\036, \023\024\ \r\024\035\016\033\013\017\005 \022\024\027\021\030\024\035\017\030\024\r\ \026\021\034 )Tj -0.024 Tw T* (\036\036 \022\030\026\016, \026)Tj /Span<>> BDC ( )Tj EMC (\017\f\023\024\035\034\024\r\026\027\017\036 \023\036\021\035\017 \023\030\ \017)Tj /Span<>> BDC ( )Tj EMC (\024\021\007\036\035\036\027\017\017 \024\023\031\b\024)Tj 0 Tw (-)Tj 0.076 Tw T* (\035\017 \024\021 \f\021\036\027\022\017 \022\017\001\022\017 \f\031\013\ \036\f\021\r\036\027\027\024 \f\024\022\030\026\013\026\036\021 \023\030\ \024\007\024\035)Tj 0 Tw (-)Tj 0.058 Tw T* (\032\017\021\036\035\034\027\024\f\021\034 \r\n\036\001\026\021\036\035\034\ \f\021\r\026 [9]. \224\021\024 \023\024\007\021\r\036\030\032\007\026\036\ \021\f\016 )Tj 0.123 Tw T* (\007\026\027\027\t\n\017 \027\036\030\026\027\007\024\n\017\017\030\024\ \r\026\027\027\t\b \017\f\f\035\036\007\024\r\026\027\017\005, \023\030\024\ )Tj 0 Tw (-)Tj 0.453 Tw T* [(\007\036\n\024\027\f\021\030\017\030\024\r\026\r\001\017\b, )0.6(\004\021\024 )0.5(\031\007\026\035\036\027\017\036 )0.6(\220\023\017\021\036\035\017\026\035\034\027\t\b )]TJ 0.108 Tw T* (\027\024\r\024\024\002\030\026\024\r\026\027\017\005 \021\024\035\f\021\ \024\005 \022\017\001\022\017 \n\036\021\024\007\024\n C-EMR \026)Tj 0 Tw (-)Tj 0.336 Tw T* (\027\017\n\026\036\021 \n\036\027\034\001\036 \r\030\036\n\036\027\017 \017\ )Tj /Span<>> BDC ( )Tj EMC (\f\024\023\030\024\r\024\032\007\026\036\021\f\016 \002\024\035\036\036 \ )Tj 0.085 Tw T* [(\027\017\022\024\005 )0.6(\004\026\f\021\024\021\024\005 )0.5(\030\026\r\017\021\017\016 )0.6(\024\f\035\024\032\027\036\027\017\005 )0.5(\023\030\017)]TJ /Span<>> BDC ( )Tj EMC 18.54 0 Td (\f\024\023\024\f\021\026)Tj 0 Tw (-)Tj 0.029 Tw -18.54 -1.218 Td (\r\017\n\024\005 \004\026\f\021\024\021\036 \030\036\006\017\007\017\r\024\ \r \023\024)Tj /Span<>> BDC ( )Tj EMC (\f\030\026\r\027\036\027\017\033 \f)Tj /Span<>> BDC ( )Tj EMC (\n\036\021\024\007\017\022\024\005 )Tj 0.092 Tw T* (ESD [10,11]. \200\n\036\f\021\036 \f)Tj /Span<>> BDC ( )Tj EMC (\021\036\n, \023\024)Tj /Span<>> BDC ( )Tj EMC (\n\027\036\027\017\033 \027\036\022\024\021\024\030\t\b \026)Tj 0 Tw (-)Tj 0.02 Tw T* (\030\031\002\036\032\027\t\b \026\r\021\024\030\024\r, \024\021\n\036\004\ \026\036\021\f\016 \024\021\030\017\006\026\021\036\035\034\027\026\016 \ \022\024\030\030\036)Tj 0 Tw (-)Tj 0.006 Tw T* (\035\016\006\017\016, \023\030\024\016\r\035\016\033\013\026\016\f\016 \002\ \024\035\036\036 \027\017\022\024\005 \004\026\f\021\024\021\024\005 \031\ \007\026\035\036)Tj 0 Tw (-)Tj 0.028 Tw T* [(\027\017\016 \024\023\031\b\024\035\017 \036\007\017\027\t\n \002\035\024\ \022\024\n \n\036\021\024\007\024\n C-EMR )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC (\f\035\031\004\026\036 )Tj ET 1 0.68 0 0.12 k /GS0 gs q 1 0 0 1 70.8661 738.9961 cm 0 0 m 0 0 l 0 -11.339 l 42.52 -11.339 l 42.52 0 l h f Q BT 0 0 0 0 k /T1_1 1 Tf 0 Tw 9 0 0 9 73.5728 730.0688 Tm (ABSTRACT)Tj 1 0.68 0 0.12 k /T1_4 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\033\030\031\030\213\b)-20.9(\035\231\213\233\t \021\032)50(\b)42(\032\231\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj -51.938 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 23, \023\0221)69(, 202)69(4)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 23, \023\0221)69(, 202)69(4)]TJ /T1_5 1 Tf 25 0 0 25 28.1026 56.0378 Tm (22)Tj ET endstream endobj 2473 0 obj [2482 0 R] endobj 2474 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\235\001\201\025\006\n)10(\025\221\220\017\016\006\n\013\205 \024\215\n)10(\025)21(\222)21(\232\n)-9.9(\026)11(\025\024\220\205 \006\022\227\220\002\n\215\007\205\002\001\020\024 \002\ \013\222\002\016\222\025\024 )]TJ 0 -1 TD [(\006)-10(\007\220\222\220\006)-9.9(\026)11(\025\203 \025\f\025\007\025\017\n\220 \r\022\007\016\017\016\001\220\220\ \025\221\215)21.1(\207\025\007\016\203 \025\f\025\201\025\017\001\025\203 \n\220\n\220. )]TJ T* [(\033\016\222)21(\215\007\216)21(\026)11(\013\026\020 \002\013\001\201\025\024\220\222\220\002\025\r\013\001\001\025\ \202)10(\025 \220\006\006)-10(\007\016\201\025\r\013\001\220\205.)]TJ 34.507 2 Td [(Endoscopic mucosal r)31(esection with a cir)31(cumfer)31.1(ential incision in th)11(e )]TJ 2.851 -1 Td [(r)31(emov)10(al of colon neoplasms. Results of a r)21(andomiz)10.1(ed trial.)]TJ ET 0 0 0 1 K 1 j 1 J [0 2.997]0 d /GS1 gs q 1 0 0 1 46.0167 272.0103 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 43.0197 272.0103 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q [0 2.997]0 d q 1 0 0 1 46.0167 225.2025 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 43.0197 225.2025 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q BT 0 0 0 1 k /T1_1 1 Tf 10 0 0 10 42.5197 724.8299 Tm (https://doi.org/10.33878/2073-7556-2024-23-1-21-31)Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 0.023 Tw 19 0 0 19 82.411 695.3259 Tm [(\235\001\201\025\006\n)10(\025\221\220\017\016\006\n\013\205 \024\215\n)10(\025)21(\222)21(\232\n)-10(\026)11(\025\024\220\205 \006\022)-23.3(\227\220\002\n\215\007\205\002\001\020\024 )]TJ -0.826 -1.105 Td [(\002\013\222\002\016\222\025\024 \006)-10(\007\220\222\220\006)-10(\026)11(\025\203 \025\f\025\007\025\017\n\220 \r\022)-23.3(\007\016\017\016\001\220\220 \025\221\215)21(\207\025\007\016\203 )]TJ -0.214 -1.105 Td [(\025\f\025\201\025\017\001\025\203 \n\220\n\220. \033\016\222)21(\215\007\216)21(\026)11(\013\026\020 \002\013\001\201\025\024\220\222\220\002\025\r\013\001\001\025\ \202)10.1(\025 )]TJ 0 Tw 7.889 -1.105 Td [(\220\006\006)-10(\007\016\201\025\r\013\001\220\205.)]TJ 0 0 0 1 k /GS1 gs 14 0 0 14 42.5197 607.822 Tm [(\b\f\201\215\007\217\013\007\220\016\r\013\022)-23.2(\235.\240)106(.)]TJ 8.162 0 0 8.162 155.3345 612.484 Tm (1)Tj 0.023 Tw 14 0 0 14 159.9704 607.822 Tm [(, \035\220\n\215)-20(\026)11.1(\025\r\022)-23.3(\b)-31(.\b)-31(.)]TJ -0.069 Tc 0.069 Tw 8.162 0 0 8.162 245.867 612.484 Tm [(1,)-69(2)]TJ 0 Tc 0.023 Tw 14 0 0 14 257.1876 607.822 Tm [(, \004\016\006\016\007\025\r\022)-23.2(\004.\004.)]TJ -0.069 Tc 0.069 Tw 8.162 0 0 8.162 337.5543 612.484 Tm [(1,)-69(2)]TJ 0 Tc 0.023 Tw 14 0 0 14 348.8749 607.822 Tm [(, \005\026\r\002\013\007\013\r\220\007\220\022)-23.2(\255.\b)-31(.)]TJ 0 Tw 8.162 0 0 8.162 475.119 612.484 Tm (1)Tj 14 0 0 14 479.755 607.822 Tm (, )Tj -31.231 -1.143 Td [(\200\202)10(\013\203\022)-23.3(\036.\005.)]TJ 8.162 0 0 8.162 109.1632 596.484 Tm (1)Tj 0.023 Tw 14 0 0 14 113.7992 591.822 Tm [(, \204\025\024\205\n)10.1(\025\r\022)-23.3(\t.\b)-31(.)]TJ -0.069 Tc 0.069 Tw 8.162 0 0 8.162 197.8201 596.484 Tm [(1,)-69(2)]TJ 0 Tc 0.023 Tw 14 0 0 14 209.1407 591.822 Tm [(, \003\016\002\001\020\025\r\022)-23.2(\021.\004.)]TJ 0 Tw 8.162 0 0 8.162 304.9635 596.484 Tm (1)Tj 0.023 Tw 14 0 0 14 309.5995 591.822 Tm [(, \021\215\n)10(\025\r\022)-23.2(\036.\030.)]TJ 0 Tw 8.162 0 0 8.162 394.1946 596.484 Tm (1)Tj 5.83 0 0 5.83 42.5197 577.4827 Tm (1)Tj 0.023 Tw 10 0 0 10 45.8311 574.1527 Tm [(\210\031\214)42(\240 \253\213\005\030\226 \n)10(\025\007\025\221\002\025\n)-9.9(\026)11(\025\007\025\202\220\220 \220\024\016\001\220 \b)-30.9(.\213.\022)-23.3(\033\020\217\220\207\273 \005\220\001\222\201\002\013\r\013 \033\025\006\ \006\220\220 \(\215\007.\022)-23.3(\021\013\007\205\024\013 \b)-20.9(\201\220\007\205, \201.\022)-23.3(2, \202)62.1(.\022)-23.3(\005\025\006\n\r\013, )]TJ -0.331 -1.2 Td [(1)125(23)58(423, \033\025\006\006\220\205\))]TJ 0 Tw ( )Tj 5.83 0 0 5.83 42.5197 553.4827 Tm (2)Tj 0.023 Tw 10 0 0 10 45.8311 550.1527 Tm [(\210\031\214)21(\036)20(\240 \255\034\036 \033)21(\005\b\213\034\036 \005\220\001\222\201\002\013\r\013 \033\025\006\006\220\ \220 \(\215\007.\022)-23.2(\214\013\002\002\220\n\013\201\001\013\205, \201.\022)-23.3(2/1)69(, \006)-10(\026\002)-31(.\022)-23.3(1)69(, \202)62(.\022)-23.2(\005\025\006\n\r\013, 1)125(2)23(5)23(99)35(3, \033\025\006\006\220\205\))]TJ /T1_1 1 Tf -0.012 Tw 9 0 0 9 90.7087 531.6488 Tm (\037\036\035\034: \t\032\026\027\021\025\024\031\023\022\021\026\002 \n\203\ \031\021\013\026 \021\031\033\n\t\032\031\030\t\024\027\031\021\021\020\004\ \025)Tj /Span<>> BDC ( )Tj EMC (\n\024\030\026\023\031\021\021\020\004 \032\031\016\205\023\022\024\026\024\ \n\027 \r\021\030\n\t\013\n\033\025\006\031\t\013\n\017 \032\031\016\031\ \013\203\025\025 \t\023\025)Tj 0 Tw (-)Tj 0.084 Tw 0 -1.111 TD (\016\025\t\024\n\017 \n\005\n\023\n\006\013\025 \t)Tj /Span<>> BDC ( )Tj EMC [(\203\025\032\013\205\023\002\032\021\020\003 \032\026\016\032\031\016\n\003\ \(endoscopic )0.5(mucosal resection with circumferential incision, C-EMR\) )]TJ 0.013 Tw T* (\025)Tj /Span<>> BDC ( )Tj EMC (\r\021\030\n\t\013\n\033\025\006\031\t\013\n\017 \030\025\t\t\031\013\203\ \025\025 \027)Tj /Span<>> BDC ( )Tj EMC (\033\n\030\t\023\025\016\025\t\024\n\003 \t\023\n\031 \(endoscopic submu\ cosal dissection, ESD\) \033\032\025)Tj /Span<>> BDC ( )Tj EMC (\023\031\006\031\021\025\025 \005\n\023\022)Tj 0 Tw (-)Tj 0.023 Tw T* (\021\020\004 \t)Tj /Span<>> BDC ( )Tj EMC (\013\032\205\033\021\020\003\025 \030\n\005\032\n\013\026\006\031\t\024\027\ \031\021\021\020\003\025 \r\033\025\024\031\023\025\026\023\022\021\020\003\ \025 \021\n\027\n\n\005\032\026\016\n\027\026\021\025\002\003\025 \n\005\ \n\030\n\006\021\n\017 \013\025\001\013\025.)Tj 0.017 Tw T* (\201\037\215\036\217\220\235 \215)Tj /Span<>> BDC ( )Tj EMC (\240\036\220\255\200\235: \t)Tj /Span<>> BDC ( )Tj EMC (\021\n\002\005\032\002 2020 \202. \033\n)Tj /Span<>> BDC ( )Tj EMC (\025\007\023\022 2022 \202. \005\020\023\n \033\032\n\027\031\030\031\021\ \n \033\032\n\t\033\031\013\024\025\027\021\n\031 \032\026\021\030\n\003\ \025\016\025\032\n\027\026\021\021\n\031 )Tj 0.075 Tw 0 -1.111 TD (\t\032\026\027\021\025\024\031\023\022\021\n\031 \025\t\t\023\031\030\n\027\ \026\021\025\031, \027)Tj /Span<>> BDC ( )Tj EMC (\013\n\024\n\032\n\031 \027\013\023\007\006\031\021\n 103 \033\026\203\025\ \031\021\024\026 \t)Tj /Span<>> BDC ( )Tj EMC (\030\n\005\032\n\013\026\006\031\t\024\027\031\021\021\020\003\025 \r\033\ \025\024\031\023\025\026\023\022\021\020\003\025 )Tj 0.078 Tw 0 -1.111 TD (\021\n\027\n\n\005\032\026\016\n\027\026\021\025\002\003\025 \n\005\n\030\ \n\006\021\n\017 \013\025\001\013\025 \032\026\016\003\031\032\026\003\025\ \n\024 20 \030\n)Tj /Span<>> BDC ( )Tj EMC (30 \003\003. \240\031\024\n\030 \207-EMR \005\020\023 \033\032\025\003\031\ \021\031\021 \205)Tj /Span<>> BDC ( )Tj EMC (52, ESD)Tj /Span<>> BDC ( )Tj EMC (\227 )Tj 0.023 Tw T* (\205)Tj /Span<>> BDC ( )Tj EMC (51 \005\n\023\022\021\n\202\n.)Tj 0.333 Tw T* [(\212\036\221\214\035\034\220\201\220\235: )0.6(\205\030\026\023\031\021\025\031 )0.6(\n\033\205\004\n\023\025 )0.6(\003\031\024\n\030\n\003 )0.6(C-EMR )0.6(\024\032\031\005\n\027\026\023\n )0.6(\t\024\026\024\025\t\024\025\006\031\t\013\025 )0.5(\016\021\026\006\025\003\n )0.5(\003\031\021\022\001\031 )0.5(\027\032\031\003\031\021\025, )]TJ 0.026 Tw T* (\033\n)Tj /Span<>> BDC ( )Tj EMC (\t\032\026\027\021\031\021\025\007 \t)Tj /Span<>> BDC ( )Tj EMC (\003\031\024\n\030\025\013\n\017 ESD)Tj /Span<>> BDC ( )Tj EMC (\227 30 \025)Tj /Span<>> BDC ( )Tj EMC (60 \003\025\021., \t\n\n\024\027\031\024\t\024\027\031\021\021\n \(p)Tj /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (0,001\). \215\021\024\032\026- \025)Tj /Span<>> BDC ( )Tj EMC (\033\n\t\023\031\n\033\031\032\026\203\025\n\021\021\020\031 )Tj -0.006 Tw T* [(\n\t\023\n\204\021\031\021\025\002 )0.5(\027\n\016\021\025\013\023\025 \205)]TJ /Span<>> BDC ( )Tj EMC (13)Tj /Span<>> BDC ( )Tj EMC [(\(23,7%\) \033\026\203\025\031\021\024\n\027 )0.5(\027)]TJ /Span<>> BDC ( )Tj EMC (\202\032\205\033\033\031 C-EMR \025)Tj /Span<>> BDC ( )Tj EMC (\205 12)Tj /Span<>> BDC ( )Tj EMC (\(23,5%\) \005\n\023\022\021\020\004 \027)Tj /Span<>> BDC ( )Tj EMC (\202\032\205\033\033\031 ESD. \217\026\025\005\n\023\031\031 )Tj 0.138 Tw T* [(\006\026\t\024\n \032\031\202\025\t\024\032\025\032\205\031\003\020\003 \ )0.5(\n\t\023\n\204\021\031\021\025\031\003 \005\020\023 \033\n\t\024\013\n\026\ \202\205\023\002\203\025\n\021\021\020\017 \t\025\021\030\032\n\003 \027\ )]TJ /Span<>> BDC ( )Tj EMC (\n\t\021\n\027\021\n\017 \025)Tj /Span<>> BDC ( )Tj EMC (\013\n\021\024\032\n\023\022\021\n\017 \202\032\205\033)Tj 0 Tw (-)Tj 0.21 Tw T* (\033\031)Tj /Span<>> BDC ( )Tj EMC (\227 \027)Tj /Span<>> BDC ( )Tj EMC (9)Tj /Span<>> BDC ( )Tj EMC (\(17,3%\) \025)Tj /Span<>> BDC ( )Tj EMC (11)Tj /Span<>> BDC ( )Tj EMC (\(21,6%\) \t\023\205\006\026\002\004, \t\n\n\024\027\031\024\t\024\027\031\ \021\021\n. \214\t\024\026\021\n\027\023\031\021\n, \006\024\n \021\031\205\ \030\n\005\021\n\031 \032\026\t\033\n\023\n\204\031\021\025\031 )Tj 0.052 Tw T* (\n\033\205\004\n\023\025 \(\255\231)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (18,3; p)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,01\) \025)Tj /Span<>> BDC ( )Tj EMC (\025\021\024\032\026\n\033\031\032\026\203\025\n\021\021\020\031 \n\t\023\ \n\204\021\031\021\025\002 \(\255\231)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (37,5; p)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,04\) \002\027\023\002\007\024\t\002 \021\031\016\026\027\025\t\025)Tj 0 Tw (-)Tj 0.018 Tw 0 -1.111 TD (\003\020\003\025 \f\026\013\024\n\032\026\003\025 \013\n\021\027\031\032\ \t\025\025 \r\021\030\n\t\013\n\033\025\006\031\t\013\n\202\n \027\003\031\ \001\026\024\031\023\022\t\024\027\026. \224\026\t\024\n\024\026 \205\030\ \026\023\031\021\025\002 \n\033\205\004\n\023\025 \031\030\025\021\020\003\ \005\023\n\013\n\003 )Tj 0.095 Tw 0 -1.111 TD (\027)Tj /Span<>> BDC ( )Tj EMC (\n\t\021\n\027\021\n\017 \025)Tj /Span<>> BDC ( )Tj EMC (\013\n\021\024\032\n\023\022\021\n\017 \202\032\205\033\033\026\004 \t\024\ \026\024\025\t\024\025\006\031\t\013\025 \016\021\026\006\025\003\n \021\ \031 \032\026\016\023\025\006\026\023\026\t\022)Tj /Span<>> BDC ( )Tj EMC (\227 \205)Tj /Span<>> BDC ( )Tj EMC (47)Tj /Span<>> BDC ( )Tj EMC (\(90,4%\) \025)Tj /Span<>> BDC ( )Tj EMC (49)Tj /Span<>> BDC ( )Tj EMC (\(96,1%\) )Tj 0.027 Tw T* [(\005\n\023\022\021\020\004, )0.5(\t\n\n\024\027\031\024\t\024\027\031\021\021\n )0.5(\(\032)]TJ /Span<>> BDC ( )Tj EMC 12.537 0 Td (=)Tj /Span<>> BDC ( )Tj EMC [(0,4\), )0.5(\024\026\013\204\031 )0.5(\013\026\013 )0.5(\025)]TJ /Span<>> BDC ( )Tj EMC [(\006\026\t\024\n\024\026 )0.6(\030\n\t\024\025\204\031\021\025\002 \021\031\202\026\024\025\027\021\020\ \004 \202\032\026\021\025\203 \032\031\016\031\013\203\025\025 \(R0\)\226\ )]TJ 0.023 Tw -12.537 -1.111 Td (\027)Tj /Span<>> BDC ( )Tj EMC (40)Tj /Span<>> BDC ( )Tj EMC (\(76,9%\) \025)Tj /Span<>> BDC ( )Tj EMC (45)Tj /Span<>> BDC ( )Tj EMC (\(88,2%\) \t\023\205\006\026\002\004, \t\n\n\024\027\031\024\t\024\027\031\ \021\021\n \(\032)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,2\).)Tj 0.191 Tw T* (\221\201\222\035\223\224\036\217\215\036: \r\021\030\n\t\013\n\033\025\006\ \031\t\013\026\002 \032\031\016\031\013\203\025\002 \t\023\025\016\025\t\ \024\n\017 \n\005\n\023\n\006\013\025 \t)Tj /Span<>> BDC ( )Tj EMC (\203\025\032\013\205\023\002\032\021\020\003 \032\026\016\032\031\016\n\003\ \002\027\023\002\031\024\t\002 \r\f\f\031\013)Tj 0 Tw (-)Tj 0.05 Tw T* (\024\025\027\021\020\003 \025)Tj /Span<>> BDC ( )Tj EMC (\005\031\016\n\033\026\t\021\020\003 \027\003\031\001\026\024\031\023\022\ \t\024\027\n\003, \t\n\033\n\t\024\026\027\025\003\020\003 \t)Tj /Span<>> BDC ( )Tj EMC (\030\025\t\t\031\013\203\025\031\017 \027)Tj /Span<>> BDC ( )Tj EMC (\033\n\030\t\023\025\016\025\t\024\n\003 \t\023\n\031, \025)Tj /Span<>> BDC ( )Tj EMC (\003\n\204\031\024 \005\020\024\022 )Tj 0.135 Tw T* (\003\031\024\n\030\n\003 \027\020\005\n\032\026 \033\032\025)Tj /Span<>> BDC ( )Tj EMC (\030\n\005\032\n\013\026\006\031\t\024\027\031\021\021\020\004 \r\033\025\ \024\031\023\025\026\023\022\021\020\004 \021\n\027\n\n\005\032\026\016\n\ \027\026\021\025\002\004 \n\005\n\030\n\006\021\n\017 \013\025\001\013\025\ \032\026\016\003\031\032\026\003\025 )Tj -0.01 Tw T* (\n\024 20 \030\n)Tj /Span<>> BDC ( )Tj EMC [(30 \003\003. \222\032\n\003\031 \024\n\202\n, \033\032\n\030\n\023\204\025\ \024\031\023\022\021\n\t\024\022 )0.5(\n\033\031\032\026\203\025\025 )0.5(\t)]TJ /Span<>> BDC ( )Tj EMC (\033\032\025\003\031\021\031\021\025\031\003 \003\031\024\n\030\026 C-EM\ R \027)Tj /Span<>> BDC ( )Tj EMC (\030\027\026 \032\026\016\026 \003\031\021\022\001\031, )Tj 0.023 Tw T* (\006\031\003 \033\032\025)Tj /Span<>> BDC ( )Tj EMC (\027\020\033\n\023\021\031\021\025\025 ESD.)Tj /T1_2 1 Tf 0.01 Tc 0.018 Tw 8 0 0 8 42.5596 296.3795 Tm [(\037\036\035\034\033\032\031\033)5( \030\036\027\032\026:)]TJ /T1_1 1 Tf 0 Tc 0.023 Tw 8.493 0 Td ( EMR, ESD, C-EMR, \r\033\025\024\031\023\025\026\023\022\021\020\031 \021\ \n\027\n\n\005\032\026\016\n\027\026\021\025\002 \024\n\023\t\024\n\017 \ \013\025\001\013\025, \203\025\032\013\205\023\002\032\021\020\017 \032\026\ \016\032\031\016, \202\025\005\032\025\030\021\020\017 \003\031\024\n\030\ )Tj /T1_2 1 Tf 0.01 Tc 0.018 Tw -8.493 -1.909 Td [(\037\027\025\024\036\023\037\022)5( \023\025\022\033\021\033\030\027\032:)]TJ /T1_1 1 Tf 0 Tc 0.023 Tw 10.401 0 Td ( \026\027\024\n\032\020 \016\026\002\027\023\002\007\024 \n\005 \n\024\t\ \205\024\t\024\027\025\025 \013\n\021\f\023\025\013\024\026 \025\021\024\ \031\032\031\t\n\027)Tj /T1_2 1 Tf 0.033 Tc -0.001 Tw -10.401 -2.617 Td [(\020\036\017)4.7( \016\023\022\023\021\027\032\026\025\023\017:)]TJ /T1_3 1 Tf 0.023 Tc 0.004 Tw 9.172 0 Td ( \202\002\007\031\035\032\026\035\017\036\r\026)Tj /Span<>> BDC ( )Tj EMC (\224.\211., \214\017\022\031\021\024\r)Tj /Span<>> BDC ( )Tj EMC (\202.\202., \200\036\f\036\035\024\r)Tj /Span<>> BDC ( )Tj EMC (\200.\200., \204\021\r\030\026\035\026\001\r\017\035\017)Tj /Span<>> BDC ( )Tj EMC (\212.\202., \236\020\026\005)Tj /Span<>> BDC ( )Tj EMC (\210.\204., \216\024\n\016\022\024\r)Tj /Span<>> BDC ( )Tj EMC (\213.\202., \223\036\030\027\t\001\024\r)Tj /Span<>> BDC ( )Tj EMC [(\221.\200.,)23( )]TJ 0.003 Tw -9.177 -1.2 Td (\221\031\001\022\024\r)Tj /Span<>> BDC ( )Tj EMC (\210.\222. \224\027\007\024\f\022\024\023\017\004\036\f\022\026\016 \n\031\ \022\024\220\022\021\024\n\017\016 \f)Tj /Span<>> BDC ( )Tj EMC (\006\017\030\022\031\035\016\030\027\t\n \030\026\030\036\024\n \f\035\ \017\017\f\021\024\005 \024\002\024\035\024\004\022\017 \r)Tj /Span<>> BDC ( )Tj EMC [(\035\036\004\036\027\017\017 \024\023\031\b\024\035\036\005 \024\002\024\ \007\024\004\027\024\005 \022\017\001\022\017.)23( )]TJ 0.001 Tc -0.035 Tw 0 -1.2 TD [(\217)0.5(\036)0.5()0.5(\031)0.5(\035)0.6(\034\021)0.6(\026)0.5(\021)0.5(\t)0.5( \030)0.5(\026)0.5(\027)0.5(\007)0.5(\024)0.5(\n)0.5(\017)0.6()0.5(\017)0.5(\030)0.5(\024)0.5(\r)0.5(\026)0.5(\027)0.5(\027)0.5(\024)0.5(\020)0.5(\024)0.5( )0.5(\017)0.5(\f)0.5(\f)0.5(\035)0.5(\036)0.5(\007)0.5(\024)0.5(\r)0.5(\026)0.5(\027)0.5(\017)0.5(\016)0.5(.)0.5( )]TJ /T1_1 1 Tf -0.001 Tw 20.119 0 Td [(\222)0.5(\n)0.5(\023)0.5(\n)0.5(\033)0.5(\032)0.5(\n)0.6(\013)0.5(\024)0.5(\n)0.5(\023)0.5(\n)0.5(\202)0.5(\025)0.5(\002)0.5(.)]TJ /T1_3 1 Tf -0.035 Tw 7.75 0 Td [( )0.5(20)0.6(24)0.5(;)0.6( \021)0.5(.)]TJ /Span<>> BDC 3.388 0 Td ( )Tj EMC 0.199 0 Td [(2)0.5(3)0.5(,)0.5( )0.5(\225)]TJ /Span<>> BDC 2.225 0 Td ( )Tj EMC 0.199 0 Td [(1)0.5(,)0.5( )0.5(\f.)]TJ /Span<>> BDC 1.619 0 Td ( )Tj EMC 0.199 0 Td [(2)0.5(1)0.5(\226)0.5(3)0.5(1)0.5(.)0.5( )0.5(ht)0.6(t)0.5(p)0.5(s)0.5(:)0.5(/)0.5(/)0.5(d)0.5(o)0.5(i)0.5(.)0.5(o)0.5(r)0.5(g)0.5(/)0.5(1)0.5(0)0.5(.)0.5(3)0.5(3)0.5(8)0.5(7)0.5(8)0.5(/)0.5(2)0.5(0)0.5(7)0.5(3)0.5(-)0.5(7)0.5(5)0.5(5)0.5(6)0.5(-)0.5(2)0.5(0)0.5(2)0.5(4)0.5(-)]TJ 0.023 Tc -0.023 Tw -35.696 -1.2 Td (23-1-21-31)Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 0 Tc 0.023 Tw 18 0 0 18 47.0224 199.0332 Tm [(Endoscopic mucosal r)31(esection with a cir)31(cumfer)31(ential incision in )]TJ -0.03 -1.167 Td [(th)11(e r)31(emov)10(al of colon neoplasms. Results of a r)21(andomiz)10.1(ed trial.)]TJ 0 0 0 1 k /GS1 gs 0 Tw 14 0 0 14 42.5197 153.5292 Tm [(Elmir)21.1(a\022)-23.3(U.\022)-23.3(Abdul)11(zhalie)11(v)10(a)]TJ 8.162 0 0 8.162 178.2562 158.1912 Tm (1)Tj 0.023 Tw 14 0 0 14 182.8921 153.5292 Tm [(, Ale)21(x)10(ei\022)-23.2(A)-31(.\022)-23.3(Lik)11(utov)]TJ -0.069 Tc 0.069 Tw 8.162 0 0 8.162 285.2005 158.1912 Tm [(1,)-69(2)]TJ 0 Tc 0.023 Tw 14 0 0 14 296.5211 153.5292 Tm [(, Victor\022)-23.2(V)62(.\022)-23.3(V)30(eselov)]TJ -0.069 Tc 0.069 Tw 8.162 0 0 8.162 398.9835 158.1912 Tm [(1,)-69(2)]TJ 0 Tc 0 Tw 14 0 0 14 410.3041 153.5292 Tm (, )Tj -26.27 -1.143 Td [(Dmitr)-31(y\022)-23.2(A)-31(.\022)-23.3(Mt)-10(vr)21(alashvili)]TJ 8.162 0 0 8.162 171.4788 142.1912 Tm (1)Tj 0.023 Tw 14 0 0 14 176.1147 137.5292 Tm [(, Oleg\022)-23.2(M.\022)-23.3(Y)40(ugai)]TJ 0 Tw 8.162 0 0 8.162 266.8738 142.1912 Tm (1)Tj 0.023 Tw 14 0 0 14 271.5097 137.5292 Tm [(, Ev)10(geny\022)-23.2(A)-31(.\022)-23.3(Kh)11(om)21(y)21(ak)11(ov)]TJ -0.069 Tc 0.069 Tw 8.162 0 0 8.162 406.145 142.1912 Tm [(1,)-69(2)]TJ 0 Tc 0 Tw 14 0 0 14 417.4656 137.5292 Tm (, )Tj -26.782 -1.143 Td [(Stanislav\022)-23.2(V)62(.\022)-23.3(Ch)11(erny)10.1(sh)11(ov)]TJ 8.162 0 0 8.162 176.0298 126.1912 Tm (1)Tj 0.023 Tw 14 0 0 14 180.6658 121.5292 Tm [(, Oleg\022)-23.2(I.\022)-23.3(Sushk)11(ov)]TJ 0 Tw 8.162 0 0 8.162 277.0106 126.1912 Tm (1)Tj 5.83 0 0 5.83 42.5197 107.19 Tm (1)Tj 0.023 Tw 10 0 0 10 45.8311 103.86 Tm [(R)20(y)21(zhikh National Medical Resear)31(ch Center of Colopr)20.1(octology \(Saly)21(ama Adily)21(a\022)-23.3(st., 2, Moscow)22(, 1)125(23)58(423, Russia\))]TJ 0 Tw ( )Tj 5.83 0 0 5.83 42.5197 95.19 Tm (2)Tj 0.023 Tw 10 0 0 10 45.8311 91.86 Tm [(Russian Medical Academ)21.1(y of Continuous Pr)20(ofessional Education \(Barrikadnay)21.1(a\022)-23.3(st., 2/1)69(, Moscow)22(, 1)125(2)23(5)23(99)35(3, )]TJ 0 Tw -0.331 -1.2 Td (Russia\))Tj ET 1 0.68 0 0.12 k /GS0 gs q 1 0 0 1 42.5197 540.1533 cm 0 0 m 0 0 l 0 -11.339 l 42.52 -11.339 l 42.52 0 l h f Q BT 0 0 0 0 k /T1_2 1 Tf 9 0 0 9 47.6607 531.226 Tm (\021\033\r\035\f\033)Tj ET q 0 0 566.929 793.701 re W n BT 1 0.68 0 0.12 k /T1_4 1 Tf 0.01 Tc 0.018 Tw 14 0 0 14 42.5895 837.3533 Tm [(\004\n\006\202\006\t\037)-20(\b\231\t\233\207)5( \017)-32(\r)41(\037)31(\r\231\006)]TJ /T1_0 1 Tf 0 -1.605 TD [(ORIGINAL)5( ARTICLES)]TJ ET Q BT 1 0.68 0 0.12 k /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\033\030\031\030\213\b)-20.9(\035\231\213\233\t \021\032)50(\b)42(\032\231\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj /T1_5 1 Tf 25 0 0 25 511.9895 56.0378 Tm (21)Tj ET q 0 g 0 G 0 j 0 J /Fm1 Do Q 0 0 0 0 k 368.504 725.67 59.155 11.338 re f /PlacedPDF /MC0 BDC q 369.135 736.808 m 368.896 736.808 368.703 736.616 368.703 736.376 c 368.703 736.376 l 368.703 726.285 l 368.703 726.045 368.896 725.853 369.135 725.853 c 369.135 725.853 l 427.035 725.853 l 427.273 725.853 427.469 726.045 427.469 726.285 c 427.469 726.285 l 427.469 736.376 l 427.469 736.616 427.273 736.808 427.035 736.808 c 427.035 736.808 l h W n q 0 g -0.0000005 -10.9560913 -10.9560913 0.0000005 398.0855785 736.8086309 cm BX /Sh0 sh EX Q Q q 368.504 725.67 59.155 11.337 re W n 0 0 0 0.84 k q 1 0 0 1 385.2169 732.4249 cm 0 0 m -0.025 0.1 -0.063 0.196 -0.112 0.287 c -0.157 0.374 -0.218 0.451 -0.292 0.515 c -0.37 0.582 -0.46 0.632 -0.558 0.664 c -0.669 0.701 -0.786 0.719 -0.903 0.717 c -1.076 0.722 -1.247 0.681 -1.4 0.6 c -1.536 0.526 -1.652 0.42 -1.74 0.292 c -1.83 0.158 -1.895 0.008 -1.934 -0.149 c -2.018 -0.48 -2.018 -0.827 -1.934 -1.158 c -1.896 -1.316 -1.83 -1.466 -1.74 -1.602 c -1.653 -1.731 -1.536 -1.837 -1.4 -1.912 c -1.247 -1.993 -1.076 -2.033 -0.903 -2.029 c -0.774 -2.032 -0.647 -2.006 -0.528 -1.955 c -0.427 -1.906 -0.337 -1.837 -0.263 -1.753 c -0.185 -1.665 -0.124 -1.563 -0.082 -1.453 c -0.034 -1.338 0 -1.218 0.019 -1.094 c 0.635 -1.094 l 0.624 -1.297 0.578 -1.497 0.497 -1.684 c 0.421 -1.857 0.312 -2.015 0.175 -2.146 c 0.039 -2.277 -0.123 -2.379 -0.3 -2.446 c -0.492 -2.519 -0.695 -2.555 -0.9 -2.552 c -1.15 -2.557 -1.397 -2.506 -1.625 -2.404 c -1.829 -2.307 -2.01 -2.169 -2.157 -1.997 c -2.308 -1.821 -2.423 -1.617 -2.497 -1.397 c -2.655 -0.924 -2.655 -0.412 -2.497 0.061 c -2.423 0.281 -2.307 0.485 -2.157 0.661 c -2.01 0.833 -1.829 0.973 -1.625 1.07 c -1.398 1.174 -1.15 1.226 -0.9 1.222 c -0.707 1.223 -0.515 1.196 -0.329 1.14 c -0.159 1.088 0.001 1.006 0.144 0.898 c 0.278 0.793 0.39 0.662 0.473 0.513 c 0.562 0.349 0.615 0.167 0.629 -0.019 c 0 -0.019 l 0 0 l f Q q 1 0 0 1 386.3458 733.5723 cm 0 0 m 0.584 0 l 0.584 -1.328 l 0.662 -1.204 0.771 -1.103 0.9 -1.033 c 1.046 -0.951 1.213 -0.91 1.381 -0.914 c 1.627 -0.9 1.869 -0.979 2.058 -1.137 c 2.234 -1.312 2.325 -1.556 2.305 -1.803 c 2.305 -3.596 l 1.716 -3.596 l 1.716 -1.976 l 1.724 -1.817 1.678 -1.66 1.585 -1.53 c 1.486 -1.43 1.347 -1.379 1.206 -1.392 c 1.114 -1.39 1.024 -1.408 0.94 -1.445 c 0.865 -1.479 0.798 -1.529 0.744 -1.591 c 0.687 -1.656 0.645 -1.73 0.616 -1.812 c 0.586 -1.896 0.571 -1.986 0.571 -2.077 c 0.571 -3.615 l 0 -3.615 l 0 0 l f Q q 1 0 0 1 389.692 731.1235 cm 0 0 m 0 -0.099 0.014 -0.198 0.043 -0.292 c 0.069 -0.382 0.112 -0.466 0.17 -0.54 c 0.229 -0.611 0.304 -0.669 0.388 -0.709 c 0.486 -0.754 0.594 -0.776 0.702 -0.773 c 0.845 -0.78 0.987 -0.742 1.108 -0.664 c 1.217 -0.582 1.296 -0.468 1.336 -0.337 c 1.881 -0.337 l 1.827 -0.603 1.675 -0.838 1.456 -0.996 c 1.35 -1.073 1.231 -1.131 1.105 -1.169 c 0.971 -1.208 0.831 -1.229 0.691 -1.227 c 0.509 -1.227 0.328 -1.191 0.16 -1.121 c 0.007 -1.063 -0.13 -0.972 -0.244 -0.855 c -0.356 -0.73 -0.44 -0.583 -0.491 -0.422 c -0.548 -0.243 -0.576 -0.056 -0.574 0.133 c -0.575 0.313 -0.545 0.493 -0.486 0.664 c -0.426 0.826 -0.335 0.974 -0.22 1.102 c 0.004 1.375 0.338 1.534 0.691 1.535 c 0.883 1.539 1.072 1.495 1.243 1.408 c 1.402 1.326 1.541 1.209 1.649 1.067 c 1.759 0.922 1.838 0.757 1.883 0.582 c 1.932 0.396 1.945 0.203 1.92 0.013 c 0 0.013 l 0 0 l 1.342 0.377 m 1.335 0.468 1.315 0.557 1.283 0.643 c 1.253 0.724 1.209 0.798 1.153 0.863 c 1.097 0.922 1.03 0.97 0.957 1.004 c 0.874 1.043 0.783 1.063 0.691 1.062 c 0.6 1.062 0.509 1.044 0.425 1.009 c 0.345 0.976 0.273 0.926 0.213 0.863 c 0.153 0.799 0.105 0.724 0.072 0.643 c 0.037 0.559 0.017 0.468 0.014 0.377 c 1.355 0.377 l h f Q q 1 0 0 1 393.8116 731.7051 cm 0 0 m -0.012 0.144 -0.082 0.276 -0.194 0.366 c -0.31 0.452 -0.451 0.495 -0.595 0.489 c -0.675 0.488 -0.755 0.476 -0.831 0.452 c -0.918 0.424 -0.998 0.375 -1.062 0.311 c -1.142 0.229 -1.202 0.131 -1.24 0.024 c -1.29 -0.132 -1.312 -0.296 -1.304 -0.459 c -1.304 -0.569 -1.292 -0.677 -1.267 -0.784 c -1.244 -0.885 -1.202 -0.983 -1.145 -1.07 c -1.09 -1.154 -1.016 -1.224 -0.93 -1.275 c -0.833 -1.33 -0.722 -1.356 -0.611 -1.352 c -0.457 -1.357 -0.307 -1.301 -0.194 -1.195 c -0.078 -1.077 -0.005 -0.922 0.011 -0.757 c 0.587 -0.757 l 0.556 -1.055 0.419 -1.332 0.202 -1.538 c -0.022 -1.721 -0.306 -1.815 -0.595 -1.803 c -0.777 -1.806 -0.958 -1.771 -1.126 -1.7 c -1.293 -1.642 -1.445 -1.547 -1.57 -1.421 c -1.68 -1.297 -1.763 -1.151 -1.814 -0.993 c -1.87 -0.822 -1.898 -0.643 -1.896 -0.462 c -1.898 -0.276 -1.871 -0.091 -1.817 0.087 c -1.766 0.252 -1.682 0.405 -1.57 0.537 c -1.459 0.664 -1.323 0.766 -1.168 0.834 c -0.991 0.914 -0.798 0.955 -0.603 0.954 c -0.457 0.954 -0.311 0.935 -0.17 0.895 c -0.039 0.858 0.084 0.799 0.194 0.72 c 0.302 0.643 0.393 0.543 0.459 0.428 c 0.531 0.298 0.572 0.155 0.582 0.008 c 0 0.008 l 0 0 l f Q q 1 0 0 1 394.8712 733.5723 cm 0 0 m 0.577 0 l 0.577 -2.048 l 1.615 -0.985 l 2.322 -0.985 l 1.323 -1.944 l 2.417 -3.604 l 1.716 -3.604 l 0.919 -2.337 l 0.577 -2.669 l 0.577 -3.604 l 0 -3.604 l h f Q q 1 0 0 1 398.712 732.5762 cm 0 0 m 0.436 0 l 0.436 0.218 l 0.429 0.352 0.448 0.486 0.488 0.614 c 0.521 0.705 0.577 0.786 0.651 0.85 c 0.717 0.905 0.795 0.943 0.879 0.961 c 0.966 0.979 1.056 0.988 1.145 0.988 c 1.28 0.993 1.416 0.981 1.548 0.954 c 1.548 0.505 l 1.509 0.516 1.469 0.523 1.429 0.528 c 1.379 0.532 1.33 0.532 1.28 0.528 c 1.209 0.53 1.14 0.511 1.081 0.473 c 1.019 0.419 0.987 0.337 0.999 0.255 c 0.999 -0.011 l 1.498 -0.011 l 1.498 -0.441 l 1.009 -0.441 l 1.009 -2.622 l 0.436 -2.622 l 0.436 -0.428 l 0.005 -0.428 l 0.005 0 l 0 0 l f Q q 1 0 0 1 401.7535 729.8965 cm 0 0 m -0.191 -0.003 -0.381 0.032 -0.559 0.104 c -0.715 0.167 -0.856 0.264 -0.972 0.388 c -1.091 0.512 -1.181 0.659 -1.238 0.82 c -1.356 1.18 -1.356 1.567 -1.238 1.925 c -1.181 2.087 -1.091 2.234 -0.972 2.358 c -0.856 2.481 -0.715 2.578 -0.559 2.643 c -0.199 2.78 0.198 2.78 0.558 2.643 c 0.714 2.578 0.855 2.481 0.972 2.358 c 1.09 2.234 1.181 2.087 1.237 1.925 c 1.355 1.567 1.355 1.18 1.237 0.82 c 1.181 0.659 1.09 0.512 0.972 0.388 c 0.855 0.266 0.713 0.169 0.558 0.106 c 0.38 0.034 0.191 -0.002 0 0 c 0 0.454 m 0.115 0.451 0.23 0.479 0.332 0.534 c 0.424 0.586 0.502 0.659 0.562 0.746 c 0.624 0.836 0.669 0.936 0.695 1.041 c 0.752 1.26 0.752 1.491 0.695 1.71 c 0.669 1.816 0.625 1.916 0.562 2.005 c 0.502 2.091 0.423 2.163 0.332 2.215 c 0.123 2.323 -0.126 2.323 -0.335 2.215 c -0.427 2.163 -0.505 2.091 -0.566 2.005 c -0.628 1.916 -0.673 1.816 -0.699 1.71 c -0.756 1.491 -0.756 1.26 -0.699 1.041 c -0.672 0.936 -0.627 0.836 -0.566 0.746 c -0.506 0.659 -0.427 0.586 -0.335 0.534 c -0.232 0.478 -0.117 0.451 0 0.454 c f Q q 1 0 0 1 403.5515 732.5762 cm 0 0 m 0.531 0 l 0.531 -0.505 l 0.55 -0.43 0.583 -0.359 0.629 -0.297 c 0.681 -0.229 0.74 -0.167 0.807 -0.114 c 0.877 -0.059 0.956 -0.014 1.039 0.019 c 1.123 0.053 1.213 0.07 1.304 0.069 c 1.52 0.069 l 1.52 -0.486 l 1.395 -0.467 l 1.269 -0.467 l 1.178 -0.468 1.087 -0.488 1.004 -0.526 c 0.917 -0.565 0.839 -0.625 0.778 -0.699 c 0.716 -0.783 0.669 -0.878 0.643 -0.98 c 0.604 -1.104 0.584 -1.233 0.586 -1.362 c 0.586 -2.603 l 0.01 -2.603 l 0.01 0 l 0 0 l f Q q 1 0 0 1 409.0202 729.9683 cm 0 0 m -0.577 0 l -0.577 0.364 l -0.649 0.23 -0.759 0.121 -0.893 0.047 c -1.022 -0.029 -1.169 -0.07 -1.32 -0.072 c -1.595 -0.095 -1.866 0.002 -2.064 0.194 c -2.234 0.413 -2.316 0.687 -2.295 0.964 c -2.295 2.608 l -1.719 2.608 l -1.719 1.014 l -1.735 0.843 -1.689 0.67 -1.588 0.531 c -1.492 0.433 -1.357 0.382 -1.219 0.39 c -1.116 0.387 -1.012 0.406 -0.917 0.446 c -0.84 0.479 -0.772 0.531 -0.72 0.595 c -0.667 0.661 -0.63 0.738 -0.611 0.82 c -0.588 0.911 -0.577 1.003 -0.577 1.097 c -0.577 2.611 l 0 2.611 l 0 0 l f Q q 1 0 0 1 409.6413 732.5762 cm 0 0 m 0.545 0 l 0.545 -0.353 l 0.617 -0.209 0.736 -0.094 0.882 -0.026 c 1.03 0.04 1.19 0.073 1.352 0.072 c 1.535 0.075 1.717 0.038 1.883 -0.037 c 2.031 -0.106 2.161 -0.208 2.263 -0.334 c 2.366 -0.465 2.442 -0.615 2.489 -0.775 c 2.54 -0.948 2.566 -1.127 2.566 -1.307 c 2.566 -1.479 2.542 -1.651 2.497 -1.817 c 2.455 -1.973 2.385 -2.121 2.29 -2.252 c 2.099 -2.522 1.789 -2.682 1.458 -2.68 c 1.369 -2.681 1.28 -2.674 1.193 -2.659 c 1.11 -2.644 1.028 -2.618 0.951 -2.584 c 0.875 -2.552 0.802 -2.509 0.736 -2.457 c 0.671 -2.406 0.615 -2.343 0.571 -2.273 c 0.571 -3.575 l -0.005 -3.575 l -0.005 0 l 0 0 l 2.008 -1.307 m 2.008 -1.191 1.993 -1.076 1.963 -0.964 c 1.936 -0.859 1.89 -0.759 1.828 -0.669 c 1.768 -0.584 1.69 -0.514 1.599 -0.462 c 1.503 -0.409 1.395 -0.382 1.286 -0.385 c 1.072 -0.372 0.867 -0.467 0.738 -0.638 c 0.607 -0.836 0.543 -1.072 0.555 -1.31 c 0.554 -1.433 0.57 -1.557 0.603 -1.676 c 0.631 -1.781 0.68 -1.879 0.747 -1.965 c 0.809 -2.044 0.886 -2.109 0.975 -2.157 c 1.071 -2.206 1.178 -2.23 1.286 -2.229 c 1.401 -2.232 1.517 -2.205 1.618 -2.148 c 1.708 -2.096 1.785 -2.025 1.843 -1.939 c 1.903 -1.85 1.945 -1.751 1.968 -1.646 c 1.995 -1.535 2.008 -1.421 2.008 -1.307 c f Q q 1 0 0 1 415.1662 729.9683 cm 0 0 m -0.545 0 l -0.545 0.353 l -0.616 0.211 -0.734 0.099 -0.879 0.034 c -1.027 -0.031 -1.187 -0.065 -1.349 -0.064 c -1.532 -0.067 -1.714 -0.03 -1.88 0.045 c -2.028 0.113 -2.158 0.214 -2.26 0.34 c -2.364 0.47 -2.441 0.62 -2.486 0.781 c -2.538 0.958 -2.564 1.143 -2.563 1.328 c -2.568 1.536 -2.536 1.742 -2.468 1.938 c -2.41 2.097 -2.319 2.242 -2.202 2.364 c -2.101 2.471 -1.977 2.555 -1.838 2.608 c -1.705 2.659 -1.563 2.685 -1.421 2.685 c -1.338 2.685 -1.256 2.678 -1.174 2.664 c -1.091 2.648 -1.01 2.624 -0.932 2.589 c -0.855 2.556 -0.783 2.514 -0.717 2.462 c -0.652 2.411 -0.597 2.349 -0.553 2.279 c -0.553 3.606 l 0.024 3.606 l 0.024 0 l 0 0 l -2.008 1.277 m -2.009 1.166 -1.994 1.056 -1.965 0.948 c -1.939 0.845 -1.896 0.748 -1.835 0.661 c -1.777 0.578 -1.699 0.508 -1.61 0.459 c -1.404 0.355 -1.162 0.355 -0.956 0.459 c -0.866 0.512 -0.789 0.585 -0.73 0.671 c -0.671 0.762 -0.626 0.862 -0.6 0.966 c -0.572 1.076 -0.558 1.188 -0.558 1.301 c -0.543 1.542 -0.612 1.781 -0.751 1.979 c -0.88 2.14 -1.078 2.229 -1.283 2.22 c -1.402 2.224 -1.52 2.196 -1.623 2.138 c -1.714 2.083 -1.793 2.009 -1.852 1.92 c -1.911 1.828 -1.954 1.725 -1.977 1.617 c -1.999 1.505 -2.01 1.392 -2.008 1.277 c f Q q 1 0 0 1 417.9787 730.5499 cm 0 0 m -0.004 -0.052 0.005 -0.104 0.026 -0.151 c 0.052 -0.185 0.094 -0.202 0.136 -0.197 c 0.197 -0.197 l 0.223 -0.2 0.25 -0.2 0.276 -0.197 c 0.276 -0.595 l 0.199 -0.619 l 0.101 -0.64 l 0 -0.656 l -0.085 -0.656 l -0.187 -0.66 -0.288 -0.635 -0.377 -0.584 c -0.461 -0.528 -0.516 -0.437 -0.528 -0.337 c -0.648 -0.451 -0.792 -0.534 -0.951 -0.579 c -1.106 -0.628 -1.269 -0.654 -1.432 -0.656 c -1.546 -0.657 -1.659 -0.641 -1.769 -0.608 c -1.872 -0.579 -1.967 -0.531 -2.053 -0.468 c -2.136 -0.405 -2.203 -0.324 -2.25 -0.231 c -2.3 -0.127 -2.326 -0.012 -2.324 0.104 c -2.33 0.24 -2.299 0.375 -2.236 0.497 c -2.181 0.594 -2.101 0.675 -2.005 0.733 c -1.905 0.791 -1.795 0.833 -1.681 0.855 c -1.562 0.88 -1.442 0.899 -1.32 0.914 c -1.222 0.933 -1.123 0.947 -1.022 0.956 c -0.938 0.963 -0.855 0.977 -0.773 0.999 c -0.708 1.014 -0.649 1.046 -0.6 1.092 c -0.556 1.144 -0.533 1.211 -0.536 1.28 c -0.534 1.344 -0.553 1.408 -0.59 1.46 c -0.624 1.507 -0.668 1.544 -0.72 1.569 c -0.775 1.596 -0.834 1.613 -0.895 1.62 c -0.955 1.624 -1.016 1.624 -1.076 1.62 c -1.215 1.625 -1.354 1.591 -1.474 1.519 c -1.581 1.45 -1.647 1.333 -1.652 1.206 c -2.231 1.206 l -2.227 1.354 -2.185 1.498 -2.108 1.625 c -2.041 1.733 -1.951 1.824 -1.843 1.891 c -1.729 1.96 -1.603 2.007 -1.472 2.032 c -1.329 2.072 -1.183 2.098 -1.036 2.109 c -0.908 2.109 -0.781 2.096 -0.656 2.069 c -0.538 2.044 -0.425 2 -0.321 1.939 c -0.225 1.88 -0.143 1.8 -0.083 1.705 c -0.02 1.599 0.012 1.478 0.008 1.354 c 0.008 0.013 l 0 0 l -0.576 0.728 m -0.674 0.667 -0.785 0.631 -0.9 0.624 c -1.028 0.612 -1.155 0.594 -1.283 0.571 c -1.343 0.561 -1.402 0.547 -1.46 0.528 c -1.515 0.511 -1.566 0.485 -1.612 0.451 c -1.657 0.419 -1.692 0.376 -1.716 0.327 c -1.742 0.267 -1.755 0.203 -1.753 0.138 c -1.755 0.079 -1.735 0.021 -1.697 -0.024 c -1.661 -0.067 -1.615 -0.103 -1.564 -0.127 c -1.509 -0.154 -1.451 -0.171 -1.392 -0.181 c -1.335 -0.19 -1.278 -0.196 -1.222 -0.197 c -1.152 -0.196 -1.083 -0.188 -1.015 -0.173 c -0.94 -0.156 -0.87 -0.127 -0.805 -0.088 c -0.74 -0.048 -0.684 0.004 -0.64 0.066 c -0.594 0.134 -0.571 0.215 -0.574 0.297 c -0.574 0.725 l h f Q q 1 0 0 1 418.3371 732.5762 cm 0 0 m 0.434 0 l 0.434 0.784 l 0.996 0.784 l 0.996 0 l 1.527 0 l 1.527 -0.43 l 0.996 -0.43 l 0.996 -1.822 l 0.993 -1.874 0.993 -1.927 0.996 -1.979 c 1 -2.018 1.011 -2.056 1.031 -2.09 c 1.05 -2.122 1.079 -2.146 1.113 -2.159 c 1.162 -2.177 1.213 -2.185 1.265 -2.183 c 1.387 -2.183 l 1.428 -2.181 1.469 -2.175 1.509 -2.165 c 1.509 -2.608 l 1.323 -2.629 l 1.261 -2.633 1.199 -2.633 1.137 -2.629 c 1.013 -2.633 0.89 -2.619 0.771 -2.587 c 0.688 -2.564 0.613 -2.52 0.553 -2.459 c 0.499 -2.4 0.462 -2.328 0.446 -2.25 c 0.427 -2.155 0.416 -2.059 0.415 -1.963 c 0.415 -0.428 l -0.019 -0.428 l -0.019 0 l 0 0 l f Q q 1 0 0 1 420.7277 731.1235 cm 0 0 m 0 -0.099 0.014 -0.198 0.042 -0.292 c 0.068 -0.382 0.112 -0.466 0.17 -0.54 c 0.229 -0.611 0.303 -0.669 0.388 -0.709 c 0.486 -0.754 0.593 -0.776 0.701 -0.773 c 0.845 -0.78 0.987 -0.742 1.107 -0.664 c 1.216 -0.582 1.296 -0.468 1.336 -0.337 c 1.88 -0.337 l 1.827 -0.603 1.674 -0.838 1.456 -0.996 c 1.349 -1.073 1.231 -1.131 1.105 -1.169 c 0.973 -1.208 0.836 -1.228 0.699 -1.227 c 0.512 -1.23 0.327 -1.196 0.154 -1.126 c 0.003 -1.066 -0.133 -0.973 -0.244 -0.855 c -0.356 -0.73 -0.44 -0.583 -0.491 -0.422 c -0.548 -0.243 -0.576 -0.056 -0.574 0.133 c -0.575 0.313 -0.546 0.493 -0.486 0.664 c -0.426 0.826 -0.336 0.974 -0.221 1.102 c 0.002 1.374 0.334 1.532 0.685 1.535 c 0.877 1.539 1.067 1.495 1.238 1.408 c 1.396 1.326 1.535 1.209 1.644 1.067 c 1.753 0.922 1.833 0.757 1.878 0.582 c 1.927 0.396 1.939 0.203 1.915 0.013 c -0.002 0.013 l 0 0 l 1.341 0.377 m 1.335 0.468 1.315 0.557 1.283 0.643 c 1.253 0.724 1.209 0.798 1.153 0.863 c 1.096 0.926 1.027 0.978 0.951 1.014 c 0.868 1.054 0.777 1.074 0.685 1.073 c 0.594 1.073 0.504 1.055 0.419 1.02 c 0.339 0.986 0.267 0.937 0.207 0.874 c 0.147 0.81 0.099 0.735 0.066 0.653 c 0.031 0.569 0.011 0.479 0.008 0.388 c 1.349 0.388 l h f Q q 1 0 0 1 423.5192 730.7994 cm 0 0 m 0.002 -0.142 0.073 -0.274 0.191 -0.353 c 0.312 -0.423 0.45 -0.458 0.59 -0.454 c 0.651 -0.458 0.711 -0.458 0.773 -0.454 c 0.839 -0.447 0.904 -0.43 0.967 -0.406 c 1.024 -0.385 1.075 -0.349 1.116 -0.303 c 1.155 -0.252 1.174 -0.189 1.168 -0.125 c 1.166 -0.057 1.138 0.008 1.089 0.056 c 1.033 0.107 0.967 0.146 0.895 0.17 c 0.809 0.201 0.72 0.226 0.629 0.245 c 0.329 0.33 l 0.224 0.352 0.121 0.38 0.019 0.415 c -0.076 0.446 -0.166 0.491 -0.247 0.55 c -0.327 0.608 -0.391 0.683 -0.436 0.771 c -0.486 0.873 -0.511 0.986 -0.507 1.1 c -0.512 1.226 -0.475 1.351 -0.404 1.456 c -0.333 1.551 -0.243 1.63 -0.138 1.687 c -0.028 1.747 0.092 1.788 0.215 1.809 c 0.337 1.832 0.462 1.843 0.587 1.843 c 0.716 1.844 0.845 1.83 0.972 1.801 c 1.09 1.774 1.202 1.727 1.304 1.663 c 1.404 1.598 1.488 1.513 1.551 1.413 c 1.621 1.3 1.663 1.173 1.676 1.041 c 1.076 1.041 l 1.059 1.155 0.989 1.253 0.887 1.307 c 0.78 1.355 0.665 1.38 0.547 1.378 c 0.5 1.381 0.452 1.381 0.403 1.378 c 0.35 1.373 0.298 1.36 0.247 1.341 c 0.2 1.325 0.157 1.297 0.122 1.262 c 0.087 1.224 0.069 1.174 0.071 1.124 c 0.069 1.058 0.096 0.995 0.146 0.951 c 0.202 0.903 0.267 0.866 0.337 0.842 c 0.424 0.811 0.512 0.786 0.603 0.768 c 0.917 0.701 l 1.021 0.678 1.124 0.65 1.224 0.616 c 1.319 0.584 1.409 0.539 1.49 0.481 c 1.662 0.359 1.762 0.16 1.755 -0.05 c 1.76 -0.189 1.723 -0.326 1.649 -0.443 c 1.582 -0.551 1.491 -0.642 1.384 -0.709 c 1.267 -0.778 1.14 -0.827 1.007 -0.855 c 0.873 -0.885 0.735 -0.9 0.598 -0.9 c 0.443 -0.902 0.29 -0.883 0.141 -0.845 c 0.01 -0.812 -0.114 -0.753 -0.223 -0.674 c -0.324 -0.601 -0.407 -0.504 -0.465 -0.393 c -0.527 -0.269 -0.559 -0.131 -0.558 0.008 c 0.019 0.008 l 0 0 l f Q 0.146 0.941 0.992 0.044 k q 1 0 0 1 372.9062 729.3892 cm 0 0 m 3.612 2.406 l 3.612 5.296 l 0 5.296 l h f Q 0 0.889 0.676 0 k q 1 0 0 1 376.5186 729.3892 cm 0 0 m -3.612 2.406 l -3.612 5.296 l 0 5.296 l h f Q 0.694 0.076 0.209 0 k q 1 0 0 1 374.7125 735.3145 cm 0 0 m -2.2 0 -3.984 -1.784 -3.984 -3.984 c -3.984 -6.184 -2.2 -7.968 0 -7.968 c 2.2 -7.968 3.984 -6.184 3.984 -3.984 c 3.984 -1.784 2.2 0 0 0 c 0 -6.993 m -1.662 -6.993 -3.009 -5.646 -3.009 -3.984 c -3.009 -2.322 -1.662 -0.975 0 -0.975 c 1.662 -0.975 3.009 -2.322 3.009 -3.984 c 3.009 -5.646 1.662 -6.993 0 -6.993 c f Q 0 0.235 0.86 0 k q 1 0 0 1 376.9137 729.2803 cm 0 0 m -1.118 -1.208 -3.015 -1.281 -4.237 -0.159 c -5.159 0.688 -5.459 2.005 -4.999 3.156 c -5.833 3.687 l -6.736 1.681 -5.843 -0.679 -3.836 -1.582 c -2.218 -2.311 -0.312 -1.881 0.836 -0.528 c 0 0 l f Q 0 0 0 0.6 k q 1 0 0 1 369.1348 736.8087 cm 0 0 m -0.238 0 -0.432 -0.193 -0.432 -0.432 c -0.432 -10.524 l -0.432 -10.763 -0.238 -10.956 0 -10.956 c 57.901 -10.956 l 58.139 -10.956 58.333 -10.763 58.333 -10.524 c 58.333 -0.432 l 58.333 -0.193 58.139 0 57.901 0 c h 57.901 -11.155 m 0 -11.155 l -0.348 -11.155 -0.631 -10.872 -0.631 -10.524 c -0.631 -0.432 l -0.631 -0.084 -0.348 0.199 0 0.199 c 57.901 0.199 l 58.249 0.199 58.532 -0.084 58.532 -0.432 c 58.532 -10.524 l 58.532 -10.872 58.249 -11.155 57.901 -11.155 c f Q EMC Q endstream endobj 2475 0 obj <> endobj 2483 0 obj <>stream Adobe Illustrator CS6 (Windows) 2021-04-12T11:45:36+05:00 2021-06-02T10:28:09+05:00 2021-06-02T10:28:09+05:00 1 False False 20.868494 3.999928 Millimeters Cyan Magenta Yellow Black Default Swatch Group 0 C=0 M=24 Y=86 K=0 PROCESS 100.000000 CMYK 0.000000 23.504999 86.022697 0.000000 C=69 M=8 Y=21 K=0 PROCESS 100.000000 CMYK 69.369003 7.635600 20.892700 0.000000 C=0 M=89 Y=68 K=0 PROCESS 100.000000 CMYK 0.000000 88.946404 67.623398 0.000000 C=15 M=94 Y=99 K=4 PROCESS 100.000000 CMYK 14.578501 94.070297 99.160698 4.416000 C=0 M=0 Y=0 K=84 PROCESS 100.000000 CMYK 0.000000 0.000000 0.000000 84.000000 C=0 M=0 Y=0 K=35 PROCESS 100.000000 CMYK 0.000000 0.000000 0.000000 35.000000 C=0 M=0 Y=0 K=60 PROCESS 100.000000 CMYK 0.000000 0.000000 0.000000 60.000004 Document application/pdf proof:pdf xmp.did:804244B35A9BEB118A6FC3C256996E2F uuid:08e30110-bdb7-4606-97ca-63fb62cbcecc uuid:21079f76-f6d7-4329-b725-f2fb35af5114 uuid:722f8893-0b3c-4402-87fb-c713f1fa0e26 uuid:21079f76-f6d7-4329-b725-f2fb35af5114 uuid:21079f76-f6d7-4329-b725-f2fb35af5114 proof:pdf saved xmp.iid:804244B35A9BEB118A6FC3C256996E2F 2021-04-12T11:45:42+05:00 Adobe Illustrator CS6 (Windows) / endstream endobj 2482 0 obj <>/Border[0 0 0]/H/N/Rect[366.504 739.008 429.659 723.67]/Subtype/Link/Type/Annot>> endobj 2484 0 obj <> endobj 2463 0 obj <>/Font<>/ProcSet[/PDF/Text/ImageB]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 2464 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 2465 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 2466 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 2467 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 2491 0 obj [2493 0 R 2494 0 R 2495 0 R 2496 0 R 2497 0 R 2498 0 R 2499 0 R 2500 0 R 2501 0 R 2502 0 R 2503 0 R 2504 0 R 2505 0 R 2506 0 R 2507 0 R 2508 0 R 2509 0 R 2510 0 R 2511 0 R 2512 0 R 2513 0 R 2514 0 R 2515 0 R 2516 0 R 2517 0 R 2518 0 R 2519 0 R] endobj 2492 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.09 Tw 8 0 0 8 70.8661 731.2159 Tm [(ing )0.5(of )0.6(anast)17(omo)17(t)-32(ic )0.6(leak)-17(a)-17(ge )0.5(foll)30.1(o)-14(wing )0.5(anter)-36.9(ior )0.5(r)-24(esec)-15.9(t)-32(ion )0.5(of )0.6(t)-13(he )0.5(r)-23.9(ec)]TJ 0 Tw (-)Tj 0.092 Tw 0 -1.25 TD [(tum: a p)25(r)-32(oposal b)12(y t)-13(he Inter)-14.9(na)15(t)-32(ional S)15(tud)17(y G)20(r)-32(oup of R)13(ec)-16(t)15(al Cancer. )]TJ /T1_1 1 Tf 0 Tw T* [(Surg)12(er)-43(y)]TJ /T1_0 1 Tf 0.023 Tw [(. 2010 Mar;147\(3\):339\22651. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw [(10.1016/j.sur)-32(g.2009.10.012)]TJ 0 0 0 1 k /GS1 gs 0.011 Tc 0.398 Tw T* (17.)Tj /Span<>> BDC ( )Tj EMC 1.839 0 Td (\221\t\004\036\r)Tj /Span<>> BDC ( )Tj EMC (\221.\222., \223\036\030\027\t\001\024\r)Tj /Span<>> BDC ( )Tj EMC (\221.\200., \202\030\026\n\026\f\006\036\r\026)Tj /Span<>> BDC ( )Tj EMC (\202.\222., \017)Tj /Span<>> BDC ( )Tj EMC [(\f\024\026\r\021.)11( )]TJ 0.01 Tc 0.386 Tw -1.839 -1.25 Td (\207\036\024\023\026\f\027\024\f\021\034 \021\024\021\026\035\034\027\024\ \005 \027\036\024\026\007\255\033\r\026\027\021\027\024\005 \021\036\030\ \026\023\017\017 \r)Tj /Span<>> BDC ( )Tj EMC [(\035\036\004\036\027\017\017)10( )]TJ 0 Tc 0.35 Tw T* (\030\026\022\026 \023\030\016\n\024\005 \022\017\001\022\017. \215\030\036\ \007\r\026\030\017\021\036\035\034\027\t\036 \030\036\031\035\034\021\026\ \021\t \030\026\027\007\024\n\017\017)Tj 0 Tw (-)Tj 0.001 Tc 0.35 Tw T* [(\030\024\r\026\027\027\024\020\024 )0.6(\017\f\f\035\036\007\024\r\026\027\017\016. )]TJ /T1_1 1 Tf -0.001 Tw 11.582 0 Td (\222\n\023\n\033\032\n\013\024\n\023\n\202\025\002)Tj /T1_0 1 Tf 0.35 Tw [(. )0.6(2022;21\(3\):76\22684.)1( )]TJ 0 Tc 0 Tw -11.582 -1.25 Td [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.33878/2073-7556-2022-21-3-76-84)Tj 0 0 0 1 k /GS1 gs 0.235 Tw -1.847 -1.25 Td (18.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (R\366del)Tj /Span<>> BDC ( )Tj EMC [(C, Mar)-22(tus)]TJ /Span<>> BDC ( )Tj EMC [(P, P)40.1(ap)32(ad)-16(oupol)30(os)]TJ /Span<>> BDC ( )Tj EMC [(T, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. P)35(r)-32(o)-16(gnost)-32(ic signif)-28(i)]TJ 0 Tw (-)Tj 0.267 Tw -1.796 -1.25 Td [(cance of tumor r)-23.9(egr)-24(ession af)-28(ter p)25(r)-23.9(eoper)-33(a)15(t)-32(i)-16(ve chemor)-33(adio)17(t)-13(her)-32.9(apy )]TJ 0.064 Tw T* [(for r)-24(ec)-16(t)15(al cancer. )]TJ /T1_1 1 Tf (J Clin Oncol.)Tj /T1_0 1 Tf [( 2005;23\(34\):8688\22696. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1200/)Tj 29.055 12.5 Td [(JC)13(O.2005.02.1329)]TJ 0 0 0 1 k /GS1 gs -0.023 Tw T* (19.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Habr-Gama)Tj /Span<>> BDC ( )Tj EMC [(A, P)30.1(er)-24(ez)]TJ /Span<>> BDC ( )Tj EMC [(RO, Nad)42(al)-31(in)]TJ /Span<>> BDC ( )Tj EMC [(W, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Oper)-32.9(a)14.9(t)-31.9(i)-16(ve ver)-10(sus nonop)]TJ 0 Tw (-)Tj 0.015 Tw -1.796 -1.25 Td [(er)-33(a)15(t)-31.9(i)-16(ve tr)-24(ea)15(tment for st)15(a)-17(ge 0 dist)15(al r)-24(ec)-15.9(t)15(al cancer foll)30(o)-14(wing chemor)-32.9(a)]TJ 0 Tw (-)Tj 0.058 Tw T* [(dia)15(t)-32(ion t)-13(her)-32.9(apy: l)30(ong-ter)-16(m r)-24(esul)56.1(ts. )]TJ /T1_1 1 Tf (Ann Surg.)Tj /T1_0 1 Tf [( 2004 O)-16(c)-15.9(t;240\(4\):711\226)]TJ 0.023 Tw T* [(8. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw [(10.1097/01.sl)-16(a.0000141194.27992.32)]TJ 0 0 0 1 k /GS1 gs 0.276 Tw T* (20.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(T)40(emmink)]TJ /Span<>> BDC ( )Tj EMC 4.084 0 Td [(SJD, )0.5(P)30(ee)-12(ter)-10(s )0.5(K)20(CMJ, Bahad)-16(oer)]TJ /Span<>> BDC ( )Tj EMC 12.706 0 Td [(RR, )0.5(e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. )0.5(W)12(a)15(tch and )]TJ 0.19 Tw -18.586 -1.25 Td [(w)-12(ai)-24(t af)-28(ter neoad)17.1(juv)-15(ant tr)-24(ea)15(tment in r)-23.9(ec)-16(t)15(al cancer: Com)10(p)32(ar)-37(ison of )]TJ 0.06 Tw T* [(outcomes in p)32(a)15(t)-32(ients wi)-23.9(t)-13(h and wi)-24(t)-13(hout a com)10(ple)-12(te r)-24(esponse a)15(t f)-28(ir)-9.9(st )]TJ -0.007 Tw T* [(r)-24(eassess)26.1(ment in t)-13(he Inter)-14.9(na)15(t)-32(ional W)12(a)15(tch & W)11.9(ai)-23.9(t Da)15.1(t)15(abase \(IWWD\). )]TJ /T1_1 1 Tf 0 Tw (Br )Tj 0.023 Tw T* (J Surg )Tj /T1_0 1 Tf [([Inter)-15(ne)-12(t]. 2023;110\(6\):676\22684. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1093/bjs/znad051)Tj /T1_2 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 70.936 603.0499 Tm (REFERENCES)Tj 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.019 Tc 0.676 Tw 8 0 0 8 70.8661 590.2152 Tm (1.)Tj /Span<>> BDC ( )Tj EMC 1.352 0 Td [(R)13.4(ec)-15.6(t)15.3(al cancer. Cl)-30.6(inical guidel)-30.6(ines. Russian S)-15.6(o)-15.7(c)-23.6(ie)-11.6(t)-9.6(y of)19.1( )]TJ 0.007 Tc 0.349 Tw -1.352 -1.25 Td [(Cl)-30.9(inicalOncol)30.1(o)-16(g)16.1(y, Asso)-15.9(c)-24(ia)15.1(t)-32(ion of Oncol)30.1(o)-16(gists of Russia, Russian)7( )]TJ 0.012 Tc 0.442 Tw T* [(S)-16(o)-15.9(c)-24(ie)-12(t)-9.9(y ofSpec)-23.9(ial)-30.9(ists in Col)30(or)-23.9(ec)-15.9(t)15(al Cancer, All-Russian P)20.1(ubl)-30.9(ic)12( )]TJ 0 Tc 0.152 Tw T* [(Or)-32(ganiza)15(t)-32(ion\231Asso)-15.9(c)-24(ia)15(t)-32(ion of Col)30(op)25(r)-32(o)-16(c)-16(t)17.1(ol)30(o)-16(gists of Russia.\232 2022; p. )]TJ 0.023 Tw T* (78. \(in Russ.\))Tj -0.113 Tw T* (2.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Bosse)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(JF, Colle)-12(t)-30(te)]TJ /Span<>> BDC ( )Tj EMC [(L, Cal)-16(ais)]TJ /Span<>> BDC ( )Tj EMC [(G, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Chemo)17(t)-13(her)-33(apy wi)-24(t)-13(h P)35(r)-24(eoper)-32.9(a)15(t)-32(i)-16(ve )]TJ -0.016 Tw -1.296 -1.25 Td [(R)-10(adio)17(t)-13(her)-32.9(apy in R)13(ec)-16(t)15(al Cancer. )]TJ /T1_1 1 Tf [(N Eng)13(l J Med. )]TJ /T1_0 1 Tf 0 Tw (2006;355\(11\):1114\22623. )Tj T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td [(10.1056/NEJM)-23.9(oa060829)]TJ 0 0 0 1 k /GS1 gs 0.039 Tw -1.847 -1.25 Td (3.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Goll)-31(ins)]TJ /Span<>> BDC ( )Tj EMC [(S, Seba)-17(g-M)-24(ontef)-27.9(ior)-24(e)]TJ /Span<>> BDC ( )Tj EMC [(D. Neoad)17(juv)-15(ant T)50(r)-24(ea)15(tment S)15(tr)-32.9(a)15(tegies )]TJ 0.094 Tw -1.296 -1.25 Td [(for L)35(o)-16(call)35(y A)15(d)-17(v)-15(anced R)13(ec)-16(t)15(al Cancer. )]TJ /T1_1 1 Tf (Clin Oncol)Tj /T1_0 1 Tf (. 2016;28\(2\):146\22651. )Tj 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td [(10.1016/j.cl)30.1(on.2015.11.003)]TJ 0 0 0 1 k /GS1 gs 0.137 Tw -1.847 -1.25 Td (4.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (Xiao)Tj /Span<>> BDC ( )Tj EMC (TX, Hou)Tj /Span<>> BDC ( )Tj EMC (WY, Mei)Tj /Span<>> BDC ( )Tj EMC [(S)-10(W, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Sur)-31.9(v)-16(i)-16(v)-15(al anal)35(y)-13(sis of ear)-30(l)35(y-onse)-12(t )]TJ 0.126 Tw -1.296 -1.25 Td [(l)30(o)-16(call)35(y ad)-17(v)-14.9(anced r)-24(ec)-16(t)15(al cancer: a r)-24(e)-12(tr)-31.9(ospec)-16(t)-32(i)-16(ve stud)17.1(y based on t)-12.9(he )]TJ 0.137 Tw T* [(Sur)-32(veill)-15.9(ance, Epidemiol)30.1(o)-16(g)16(y, and End R)13(esul)56.1(ts \(SEER\) d)42(a)15(t)15(abase. 2023 )]TJ 0.023 Tw T* [(Jan;26\(1\):75\22683. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.3760/cma.j.cn441530-20220704-00291)Tj 0 0 0 1 k /GS1 gs 0.165 Tw T* (5.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(P)30(ee)-12(ter)-9.9(s K)20(CMJ, Mar)-37(ijnen)]TJ /Span<>> BDC ( )Tj EMC [(C)20(AM, Na)-17(g)17(tegaal)]TJ /Span<>> BDC ( )Tj EMC [(ID, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. T)47(he TME tr)-37(ial )]TJ 0.239 Tw -1.296 -1.25 Td [(af)-28(ter a median foll)30(o)-13.9(w-up of 6 year)-9.9(s: incr)-24(eased l)30(o)-16(cal contr)-31.9(ol but )]TJ 0.282 Tw T* [(no sur)-31.9(v)-16(i)-16(v)-15(al benef)-28(i)-24(t in ir)-24(r)-32.9(adia)15(ted p)32(a)15(t)-32(ients wi)-24(t)-12.9(h r)-24(esec)-16(t)15.1(able r)-24(ec)-15.9(t)15(al )]TJ 0 Tw T* [(car)-32(c)-24(inoma. )]TJ /T1_1 1 Tf 0.133 Tw 4.852 0 Td (Ann Surg.)Tj /T1_0 1 Tf [( 2007 N)-14(ov;246\(5\):693\226701. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1097/01.)Tj -4.852 -1.25 Td [(sl)-16(a.0000257358.56863.ce)]TJ 0 0 0 1 k /GS1 gs 0.335 Tw T* (6.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Mar)-22(t)-32(in)]TJ /Span<>> BDC ( )Tj EMC [(S)-21(T, Heneghan)]TJ /Span<>> BDC ( )Tj EMC [(HM, W)-16(inter)]TJ /Span<>> BDC ( )Tj EMC [(DC. Sy)-13(stema)15.1(t)-32(ic r)-23.9(ev)-16(iew and )]TJ -0.001 Tw -1.296 -1.25 Td [(me)-12(t)15(a-anal)35.1(y)-13(sis of outcomes foll)30.1(o)-14(wing p)32(a)15(t)-13(hol)30.1(o)-16(gical com)10(ple)-11.9(te r)-24(esponse )]TJ 0.297 Tw T* [(t)17(o neoad)17(juv)-15(ant chemor)-33(adio)17(t)-13(her)-32.9(apy for r)-24(ec)-16(t)15.1(al cancer. )]TJ /T1_1 1 Tf (Br J Surg)Tj /T1_0 1 Tf 0 Tw (. )Tj 0.023 Tw T* [(2012;99\(7\):918\22628. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1002/bjs.8702)Tj 0 0 0 1 k /GS1 gs 0.023 Tw [( Epub 2012 F)10(eb 23.)]TJ -0.095 Tw T* (7.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Z)25(or)-32(col)30(o)]TJ /Span<>> BDC ( )Tj EMC [(L, R)11(os)26(man)]TJ /Span<>> BDC ( )Tj EMC [(A)35(S, R)13(est)-32(i)-16(vo)]TJ /Span<>> BDC ( )Tj EMC [(A, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Com)10(ple)-11.9(te p)32(a)15(t)-13(hol)30(o)-16(gic r)-23.9(esponse )]TJ 0.102 Tw -1.296 -1.25 Td [(af)-28(ter combined mod)42(al)-31(i)-24(t)-10(y tr)-24(ea)15.1(tment for r)-24(ec)-15.9(t)15(al cancer and l)30(ong-ter)-16(m )]TJ 0.32 Tw T* [(sur)-32(v)-16(i)-15.9(v)-15(al: A me)-12(t)15(a-anal)35(y)-12.9(sis. )]TJ /T1_1 1 Tf (Ann Surg Oncol)Tj /T1_0 1 Tf (. 2012;19\(9\):2822\22632. )Tj 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1245/s10434-011-2209-y)Tj 0 0 0 1 k /GS1 gs 0.054 Tw -1.847 -1.25 Td (8.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Y)40(oen)]TJ /Span<>> BDC ( )Tj EMC [(H, P)40(ar)-23.9(k)]TJ /Span<>> BDC ( )Tj EMC (HE, Kim)Tj /Span<>> BDC ( )Tj EMC [(SH, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. P)35(r)-32(o)-16(gnost)-32(ic v)-15(al)35(ue of tumor r)-24(egr)-23.9(es)]TJ 0 Tw (-)Tj 0.315 Tw -1.296 -1.25 Td [(sion gr)-33(ade on MR in r)-24(ec)-16(t)15.1(al cancer: A l)-16(ar)-32(ge-scale, single-center )]TJ 0 Tw T* [(e)-18(xper)-36.9(ience. )]TJ /T1_1 1 Tf 0.267 Tw 5.214 0 Td [(K)18(orean )0.5(J )0.5(R)20(adiol. )]TJ /T1_0 1 Tf 7.395 0 Td [(2020;21\(9\):1065\22676. )0.5(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw 11.289 0 Td (10.3348/)Tj -23.899 -1.25 Td (kjr.2019.0797)Tj 0 0 0 1 k /GS1 gs 0.262 Tw T* (9.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Co)14(x)]TJ /Span<>> BDC ( )Tj EMC [(JD, S)15(te)-12(tz)]TJ /Span<>> BDC ( )Tj EMC [(J)15(A, P)40(ajak)]TJ /Span<>> BDC ( )Tj EMC [(TF. T)45(o)14(xic)-24(i)-24(t)-10(y cr)-37(i)-23.9(ter)-37(ia of t)-13(he R)-10(adia)15(t)-32(ion )]TJ 0.102 Tw -1.296 -1.25 Td [(T)47(her)-33(apy Oncol)30(o)-16(g)16(y G)20(r)-31.9(oup \(R)-12(T)20(OG\) and t)-12.9(he Eur)-31.9(opean or)-32(ganiza)15.1(t)-32(ion for )]TJ 0.158 Tw T* [(r)-24(esear)-31.9(ch and tr)-23.9(ea)15(tment of cancer \(EOR)-12(T)35(C\). )]TJ /T1_1 1 Tf [(Int J R)20(adiat Oncol Biol )]TJ 0 Tw T* [(Ph)12(ys.)]TJ /T1_0 1 Tf 0.023 Tw [( 1995;31\(5\):1341\2266. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1016/0360-3016\(95\)00060-C)Tj 0 0 0 1 k /GS1 gs -0.055 Tw T* (10.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Cancer T)47(her)-33(apy Ev)-15(al)35(ua)15(t)-32(ion P)35(r)-32(o)-16(gr)-33(am \(CTEP\). Common T)40(er)-16(minol)30(o)-16(g)16(y )]TJ -0.032 Tw -1.796 -1.25 Td [(Cr)-37(i)-23.9(ter)-37(ia for A)15(d)-17(ver)-10(se Events \(CT)35(C)20(AE\).v.5.0 [5x7]. )]TJ /T1_1 1 Tf [(Cancer Ther Ev)16(al Prog)14(r)]TJ /T1_0 1 Tf 0 Tw ( )Tj 0.099 Tw T* [([Inter)-15(ne)-11.9(t]. 2017;155. A)15(v)-15(ail)-15.9(able fr)-32(om: ht)-30(tps://c)-15.9(tep.cancer.gov/p)25.1(r)-32(o)]TJ 0 Tw (-)Tj T* [(t)17(o)-16(colDevel)30.1(opment/elec)-16(tr)-31.9(onic_appl)-31(ica)15(t)-32(ions/c)-15.9(tc.htm#c)-16(tc_50)]TJ -0.051 Tw 29.055 48.75 Td (11.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Heald)Tj /Span<>> BDC ( )Tj EMC [(RJ, M)-24(or)-33(an)]TJ /Span<>> BDC ( )Tj EMC [(BJ, R)-20(y)22(all)]TJ /Span<>> BDC ( )Tj EMC [(RD, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. R)13(ec)-16(t)15(al cancer: t)-12.9(he Basingst)17.1(ok)9.9(e )]TJ 0.035 Tw -1.796 -1.25 Td [(e)-18(xper)-36.9(ience of t)17(o)17(t)15(al mesor)-24(ec)-16(t)15(al e)-18(x)-12.9(c)-24(ision, 1978-1997. )]TJ /T1_1 1 Tf (Arch Surg.)Tj /T1_0 1 Tf ( 1998 )Tj 0.023 Tw T* [(A)10(ug;133\(8\):894\2269. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw [(10.1001/ar)-32(chsur)-31.9(g.133.8.894)]TJ 0 0 0 1 k /GS1 gs 0.131 Tw T* (12.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Cam)10(p)32(a-T)47(hom)10(pson)]TJ /Span<>> BDC ( )Tj EMC [(M, W)22(eir)]TJ /Span<>> BDC ( )Tj EMC [(R, Cal)16(ce)-12(ter)-33(a)]TJ /Span<>> BDC ( )Tj EMC [(N, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. P)40(a)15(t)-13(hol)30(o)-16(gic p)24.9(r)-31.9(o)]TJ 0 Tw (-)Tj 0.018 Tw -1.796 -1.25 Td [(cessing of t)-13(he t)17(o)17(t)15.1(al mesor)-23.9(ec)-16(t)15(al e)-18(x)-12.9(c)-24(ision. )]TJ /T1_1 1 Tf [(Clin Colon R)21(ectal Surg.)]TJ /T1_0 1 Tf ( 2015 )Tj 0.023 Tw T* [(Mar;28\(1\):43\22652. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1055/s-0035-1545069)Tj 0 0 0 1 k /GS1 gs 0.183 Tw T* (13.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Amin)Tj /Span<>> BDC ( )Tj EMC [(MB, G)20(r)-24(eene)]TJ /Span<>> BDC ( )Tj EMC (FL, Edge)Tj /Span<>> BDC ( )Tj EMC [(SB, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. T)47(he Eight)-13(h Edi)-23.9(t)-32(ion AJCC )]TJ 0.124 Tw -1.796 -1.25 Td [(Cancer S)15(t)15(a)-17(ging Manual: )0.5(Cont)-32(inuing t)17(o build a br)-37(idge fr)-32(om a popu)]TJ 0 Tw (-)Tj 0.117 Tw T* [(l)-16(a)15(t)-32(ion-based t)17(o a mor)-24(e \231per)-10(sonal)-31(ized\232 app)25(r)-32(oa)-17(ch t)17(o cancer st)15(a)-17(ging. )]TJ /T1_1 1 Tf 0.295 Tw T* [(C)-18(A: a cancer jour)-14(nal for clinicians. U)22(nited S)28(tates.)]TJ /T1_0 1 Tf ( 2017;67:93\2269. )Tj 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td [(10.3322/caa)-17(c.21388)]TJ 0 0 0 1 k /GS1 gs 0.017 Tw -1.847 -1.25 Td (14.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(R)-20(y)22(an)]TJ /Span<>> BDC ( )Tj EMC 2.201 0 Td [(JE, )0.5(W)12(ar)-24(r)-36.9(ier)]TJ /Span<>> BDC ( )Tj EMC 4.525 0 Td [(SK, )0.5(L)70(ynch)]TJ /Span<>> BDC ( )Tj EMC 3.959 0 Td [(A)16(C, )0.5(e)-12(t)]TJ /Span<>> BDC ( )Tj EMC 2.52 0 Td [(al. )0.5(Assessing )0.6(p)32(a)15(t)-13(hol)30(o)-16(gical )0.5(com)]TJ 0 Tw (-)Tj -0.072 Tw -15.001 -1.25 Td [(ple)-12(te r)-24(esponse t)17(o neoad)17(juv)-15(ant chemor)-33(adio)17(t)-13(her)-32.9(apy in l)30.1(o)-16(call)35(y ad)-17(v)-14.9(anced )]TJ -0.032 Tw T* [(r)-24(ec)-15.9(t)15(al cancer: a sy)-13(stema)15(t)-32(ic r)-24(ev)-16(iew. )]TJ /T1_1 1 Tf [(Color Dis Of)-39.9(f J Assoc Colop)46(roctology )]TJ 0.023 Tw T* [(Gt Br)-36.9(itain Irel. )]TJ /T1_0 1 Tf [(2015 O)-16(c)-16(t;17\(10\):849\22661. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1111/codi.13081)Tj 0 0 0 1 k /GS1 gs 0.176 Tw T* (15.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Dind)-16(o)]TJ /Span<>> BDC ( )Tj EMC [(D, Demar)-22(t)-32(ines)]TJ /Span<>> BDC ( )Tj EMC [(N, Cl)-16(av)-16(ien P-A. Cl)-15.9(assif)-28(ica)15(t)-32(ion of sur)-32(gical )]TJ 0.102 Tw -1.796 -1.25 Td [(com)10(pl)-31(ica)15.1(t)-32(ions: a new p)25(r)-32(oposal wi)-24(t)-12.9(h ev)-15(al)35(ua)15(t)-32(ion in a cohor)-22(t of 6336 )]TJ 0.006 Tw T* [(p)32(a)15(t)-32(ients and r)-24(esul)56.1(ts of a sur)-32(ve)-10.9(y. )]TJ /T1_1 1 Tf (Ann Surg.)Tj /T1_0 1 Tf [( 2004 A)10(ug;240\(2\):205\22613. )]TJ 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td [(10.1097/01.sl)-15.9(a.0000133083.54934.ae)]TJ 0 0 0 1 k /GS1 gs 0.043 Tw -1.847 -1.25 Td (16.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(R)-10(ahbar)-37(i)]TJ /Span<>> BDC ( )Tj EMC [(NN, W)22(ei)-23.9(tz)]TJ /Span<>> BDC ( )Tj EMC [(J, Hohenber)-32(ger)]TJ /Span<>> BDC ( )Tj EMC [(W, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Def)-28(ini)-24(t)-31.9(ion and gr)-32.9(ad)]TJ 0 Tw (-)Tj 0.09 Tw -1.796 -1.25 Td [(ing )0.6(of )0.5(anast)17(omo)17(t)-32(ic )0.6(leak)-17(a)-17(ge )0.5(foll)30.1(o)-14(wing )0.5(anter)-36.9(ior )0.5(r)-24(esec)-15.9(t)-32(ion )0.5(of )0.6(t)-13(he )0.5(r)-23.9(ec)]TJ 0 Tw (-)Tj 0.092 Tw T* [(tum: a p)25(r)-32(oposal b)12(y t)-13(he Inter)-14.9(na)15(t)-32(ional S)15(tud)17(y G)20(r)-32(oup of R)13(ec)-16(t)15(al Cancer. )]TJ /T1_1 1 Tf 0 Tw T* [(Surg)12(er)-43(y)]TJ /T1_0 1 Tf 0.023 Tw [(. 2010 Mar;147\(3\):339\22651. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw [(10.1016/j.sur)-31.9(g.2009.10.012)]TJ 0 0 0 1 k /GS1 gs 0.07 Tw T* (17.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Sychev)Tj /Span<>> BDC ( )Tj EMC [(S.I., Cher)-14.9(ny)-13(shov)]TJ /Span<>> BDC ( )Tj EMC [(S.V., Ar)-24(zamastsev)-14.9(a)]TJ /Span<>> BDC ( )Tj EMC [(A.I., e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Safe)-12(t)-9.9(y of )]TJ -0.078 Tw -1.796 -1.25 Td [(t)-13(he t)17(o)17(t)15(al neo-ad)17.1(juv)-15(ant t)-13(her)-33(apy in r)-23.9(ec)-16(t)15(al cancer tr)-24(ea)15(tment. P)35(r)-24(el)-31(iminar)-23.9(y )]TJ 0.09 Tw T* [(r)-24(esul)56.1(ts of t)-12.9(he r)-33(and)-16(omized tr)-37(ial. )]TJ /T1_1 1 Tf 0 Tw [(K)18(olop)46(roktologia)]TJ /T1_0 1 Tf 0.09 Tw (. 2022;21\(3\):76\22684. )Tj 0.023 Tw T* [(\(in Russ.\). d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.33878/2073-7556-2022-21-3-76-84)Tj 0 0 0 1 k /GS1 gs 0.218 Tw T* (18.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(R\366delC, Mar)-22(tusP, P)40(ap)32(ad)-16(oupol)30(osT, e)-12(t)15(al. P)35(r)-32(o)-16(gnost)-31.9(ic signif)-27.9(icance )]TJ 0.01 Tc 0.369 Tw -1.796 -1.25 Td [(of tumor r)-23.9(egr)-23.8(ession af)-27.9(ter p)25.2(r)-23.9(eoper)-32.9(a)15.1(t)-31.8(i)-15.9(ve chemor)-32.9(adio)17.1(t)-12.9(her)-32.9(apy for)10( )]TJ 0 Tc 0.268 Tw T* [(r)-24(ec)-15.9(t)15(al cancer. )]TJ /T1_1 1 Tf (J Clin Oncol.)Tj /T1_0 1 Tf [( 2005;23\(34\):8688\22696. d)-15.9(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1200/)Tj T* [(JC)13(O.2005.02.1329)]TJ 0 0 0 1 k /GS1 gs -0.023 Tw T* (19.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Habr-Gama)Tj /Span<>> BDC ( )Tj EMC [(A, P)30.1(er)-24(ez)]TJ /Span<>> BDC ( )Tj EMC [(RO, Nad)42(al)-31(in)]TJ /Span<>> BDC ( )Tj EMC [(W, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Oper)-32.9(a)14.9(t)-31.9(i)-16(ve ver)-10(sus nonop)]TJ 0 Tw (-)Tj 0.015 Tw -1.796 -1.25 Td [(er)-33(a)15(t)-31.9(i)-16(ve tr)-24(ea)15(tment for st)15(a)-17(ge 0 dist)15(al r)-24(ec)-15.9(t)15(al cancer foll)30(o)-14(wing chemor)-32.9(a)]TJ 0 Tw (-)Tj 0.058 Tw T* [(dia)15(t)-32(ion t)-13(her)-32.9(apy: l)30(ong-ter)-16(m r)-24(esul)56.1(ts. )]TJ /T1_1 1 Tf (Ann Surg.)Tj /T1_0 1 Tf [( 2004 O)-16(c)-15.9(t;240\(4\):711\226)]TJ 0.023 Tw T* [(8. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw [(10.1097/01.sl)-16(a.0000141194.27992.32)]TJ 0 0 0 1 k /GS1 gs 0.276 Tw T* (20.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(T)40(emmink)]TJ /Span<>> BDC ( )Tj EMC 4.084 0 Td [(SJD, )0.5(P)30(ee)-12(ter)-10(s )0.5(K)20(CMJ, Bahad)-16(oer)]TJ /Span<>> BDC ( )Tj EMC 12.706 0 Td [(RR, )0.5(e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. )0.5(W)12(a)15(tch and )]TJ 0.19 Tw -18.586 -1.25 Td [(w)-12(ai)-24(t af)-28(ter neoad)17.1(juv)-15(ant tr)-24(ea)15(tment in r)-23.9(ec)-16(t)15(al cancer: Com)10(p)32(ar)-37(ison of )]TJ 0.06 Tw 0 -1.25 TD [(outcomes in p)32(a)15(t)-32(ients wi)-23.9(t)-13(h and wi)-24(t)-13(hout a com)10(ple)-12(te r)-24(esponse a)15(t f)-28(ir)-9.9(st )]TJ -0.007 Tw 0 -1.25 TD [(r)-24(eassess)26.1(ment in t)-13(he Inter)-14.9(na)15(t)-32(ional W)12(a)15(tch & W)11.9(ai)-23.9(t Da)15.1(t)15(abase \(IWWD\). )]TJ /T1_1 1 Tf 0 Tw (Br )Tj 0.023 Tw T* (J Surg )Tj /T1_0 1 Tf [([Inter)-15(ne)-12(t]. 2023;110\(6\):676\22684. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1093/bjs/znad051)Tj /T1_3 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\021\032)50(\b)42(\032\231\027 \213\036)30.1(\005\t\033)30(\b)]TJ 52.896 0 Td (LEADING ARTICLE)Tj -52.896 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 23, \023\0221)69(, 202)69(4)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 23, \023\0221)69(, 202)69(4)]TJ /T1_4 1 Tf 25 0 0 25 28.1026 56.0378 Tm (20)Tj ET endstream endobj 2493 0 obj <>/Border[0 0 0]/H/N/Rect[199.026 718.512 290.673 709.056]/Subtype/Link/Type/Annot>> endobj 2494 0 obj <>/Border[0 0 0]/H/N/Rect[85.6442 668.512 212.452 659.216]/Subtype/Link/Type/Annot>> endobj 2495 0 obj <>/Border[0 0 0]/H/N/Rect[262.057 638.512 291.968 629.056]/Subtype/Link/Type/Annot>> endobj 2496 0 obj <>/Border[0 0 0]/H/N/Rect[303.307 738.512 362.099 729.216]/Subtype/Link/Type/Annot>> endobj 2497 0 obj <>/Border[0 0 0]/H/N/Rect[326.503 698.512 450.903 689.216]/Subtype/Link/Type/Annot>> endobj 2498 0 obj <>/Border[0 0 0]/H/N/Rect[448.797 648.512 518.805 639.056]/Subtype/Link/Type/Annot>> endobj 2499 0 obj <>/Border[0 0 0]/H/N/Rect[85.6442 527.511 164.972 518.215]/Subtype/Link/Type/Annot>> endobj 2500 0 obj <>/Border[0 0 0]/H/N/Rect[85.6442 497.511 176.74 488.215]/Subtype/Link/Type/Annot>> endobj 2501 0 obj <>/Border[0 0 0]/H/N/Rect[144.75 457.511 283.877 448.215]/Subtype/Link/Type/Annot>> endobj 2502 0 obj <>/Border[0 0 0]/H/N/Rect[251.689 417.511 291.968 408.055]/Subtype/Link/Type/Annot>> endobj 2503 0 obj <>/Border[0 0 0]/H/N/Rect[70.8661 407.511 154.218 398.215]/Subtype/Link/Type/Annot>> endobj 2504 0 obj <>/Border[0 0 0]/H/N/Rect[153.286 367.511 210.91 358.215]/Subtype/Link/Type/Annot>> endobj 2505 0 obj <>/Border[0 0 0]/H/N/Rect[85.6442 327.511 178.676 318.215]/Subtype/Link/Type/Annot>> endobj 2506 0 obj <>/Border[0 0 0]/H/N/Rect[262.057 297.511 291.968 288.055]/Subtype/Link/Type/Annot>> endobj 2507 0 obj <>/Border[0 0 0]/H/N/Rect[70.8661 287.511 115.93 278.215]/Subtype/Link/Type/Annot>> endobj 2508 0 obj <>/Border[0 0 0]/H/N/Rect[172.128 247.511 277.328 238.055]/Subtype/Link/Type/Annot>> endobj 2509 0 obj <>/Border[0 0 0]/H/N/Rect[382.223 577.511 475.398 568.215]/Subtype/Link/Type/Annot>> endobj 2510 0 obj <>/Border[0 0 0]/H/N/Rect[377.287 547.511 459.943 538.215]/Subtype/Link/Type/Annot>> endobj 2511 0 obj <>/Border[0 0 0]/H/N/Rect[318.085 497.511 384.901 488.215]/Subtype/Link/Type/Annot>> endobj 2512 0 obj <>/Border[0 0 0]/H/N/Rect[450.607 457.511 516.615 448.055]/Subtype/Link/Type/Annot>> endobj 2513 0 obj <>/Border[0 0 0]/H/N/Rect[318.085 417.511 441.924 408.215]/Subtype/Link/Type/Annot>> endobj 2514 0 obj <>/Border[0 0 0]/H/N/Rect[431.467 377.511 523.114 368.055]/Subtype/Link/Type/Annot>> endobj 2515 0 obj <>/Border[0 0 0]/H/N/Rect[353.809 337.511 480.617 328.215]/Subtype/Link/Type/Annot>> endobj 2516 0 obj <>/Border[0 0 0]/H/N/Rect[494.498 307.511 524.409 298.055]/Subtype/Link/Type/Annot>> endobj 2517 0 obj <>/Border[0 0 0]/H/N/Rect[303.307 297.511 362.099 288.215]/Subtype/Link/Type/Annot>> endobj 2518 0 obj <>/Border[0 0 0]/H/N/Rect[326.503 257.511 450.903 248.215]/Subtype/Link/Type/Annot>> endobj 2519 0 obj <>/Border[0 0 0]/H/N/Rect[448.797 207.511 518.805 198.055]/Subtype/Link/Type/Annot>> endobj 2546 0 obj <> endobj 2545 0 obj <> endobj 2544 0 obj <> endobj 2543 0 obj <> endobj 2542 0 obj <> endobj 2541 0 obj <> endobj 2540 0 obj <> endobj 2539 0 obj <> endobj 2538 0 obj <> endobj 2537 0 obj <> endobj 2536 0 obj <> endobj 2535 0 obj <> endobj 2534 0 obj <> endobj 2533 0 obj <> endobj 2532 0 obj <> endobj 2531 0 obj <> endobj 2530 0 obj <> endobj 2529 0 obj <> endobj 2528 0 obj <> endobj 2527 0 obj <> endobj 2526 0 obj <> endobj 2525 0 obj <> endobj 2524 0 obj <> endobj 2523 0 obj <> endobj 2522 0 obj <> endobj 2521 0 obj <> endobj 2520 0 obj <> endobj 2489 0 obj [2547 0 R 2548 0 R 2549 0 R 2550 0 R 2551 0 R 2552 0 R 2553 0 R 2554 0 R 2555 0 R 2556 0 R 2557 0 R 2558 0 R 2559 0 R 2560 0 R 2561 0 R] endobj 2490 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\235\225\225\016\n)-10(\026\220\r\001\025\006)-10(\026\216 \026)11(\025\026)11(\013\007\216\001\025\203 \001\016\025\013\201\230\212\r\013\001\026\001\025\ \203 \026)11(\016\002\013\221\220\220 \r\022\007\016\017\016\001\220\220 \002\013\n\013\ )]TJ 0 -1 TD [(\221\002\205\024\025\203 \n\220\n\220. \033\016\222)21(\215\007\216)21.1(\026)10.9(\013\026\020 \002\013\001\201\025\024\220\222\220\002\025\r\013\001\001\025\ \202)10(\025 \220\006\006)-9.9(\007\016\201\025\r\013\001\220\205)]TJ 39.131 1 Td [(Ef)-31(fectiv)12(eness of th)11(e total neoadju)10.1(v)10(ant th)11(er)21.1(apy in r)31(ectal )]TJ 2.292 -1 Td [(cancer tr)31(eatment. Results of th)11(e r)21(andomiz)10(ed trial)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0.211 Tw 10 0 0 10 42.5197 724.8299 Tm (\002\024\035\034\027\t\b, \004\021\024 \002\t\035\024 \f\r\016\026\027\024\ \f)Tj /Span<>> BDC ( )Tj EMC [(\023\026\027\007\036\n\017\036\005 C)13(OVID-19. )]TJ 0.412 Tw 0 -1.218 TD (\221)Tj /Span<>> BDC ( )Tj EMC (\007\030\031\020\024\005 \f\021\024\030\024\027\t, \023\030\024\r\036\007\ \036\027\017\036 \022\024\027\f\024\035\017\007\017\030\031\033\013\036\005\ )Tj 0.158 Tw T* (\b\017\n\017\024\021\036\030\026\023\017\017 \031)Tj /Span<>> BDC ( )Tj EMC (\030\016\007\026 \002\024\035\034\027\t\b \023\024)Tj /Span<>> BDC ( )Tj EMC (\n\036\f\021\031 \032\017\021\036\035\034\f\021\r\026 )Tj 0.221 Tw T* [(\002\t\035\024 )0.5(\f\r\016\026\027\024 )0.6(\f)]TJ /Span<>> BDC ( )Tj EMC 7.178 0 Td [(\027\026\030\031\001\036\027\017\036\n )0.6(\023\030\024\021\024\022\024\035\026 )0.5(\017\f\f\035\036\007\024\r\026)]TJ 0 Tw (-)Tj 0.192 Tw -7.178 -1.218 Td (\027\017\016, \004\021\024 \002\t\035\024 \027\036\017\002\036\032\027\t\ \n \r)Tj /Span<>> BDC ( )Tj EMC (\031\f\035\024\r\017\016\b \004\030\036\n\036\030\027\024\005 )Tj 0.399 Tw T* (\027\026\020\030\031\022\017 \027\026)Tj /Span<>> BDC ( )Tj EMC (\007\030\026\r\024\024\b\030\026\027\036\027\017\036 \r)Tj /Span<>> BDC ( )Tj EMC (\027\036\002\035\026\020\024\023\030\017\016\021\027\024\005 )Tj 0 Tw 0 -1.218 TD (\220\023\017\007\036\n\017\024\035\024\020\017\004\036\f\022\024\005 \024\ \002\f\021\026\027\024\r\022\036.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 42.5896 615.2278 Tm [(\020)21(\026\027\r\242\224\034\022\031\034)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0 Tc 0.031 Tw 10 0 0 10 42.5197 590.8718 Tm (\215\030\036\007\r\026\030\017\021\036\035\034\027\t\036 \030\036\031\035\ \034\021\026\021\t \f\r\017\007\036\021\036\035\034\f\021\r\031\033\021 \ \024)Tj /Span<>> BDC ( )Tj EMC (\021\024\n, )Tj 0.082 Tw 0 -1.218 TD (\004\021\024 \023\030\017\n\036\027\036\027\017\036 \021\024\021\026\035\ \034\027\024\005 \027\036\024\026\007\255\033\r\026\027\021\027\024\005 \ \021\036\030\026\023\017\017 )Tj -0.006 Tw T* [(\016\r\035\016\036\021\f\016 \002\036\024\023\026\f\027\024\005 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC [(\220\235\235\036\022\021\017\r\027\024\005 )0.5(\026\035\034\021\036\030\027\026\021\017\r\027\024\005 )]TJ 0.015 Tw T* (\f\021\026\027\007\026\030\021\027\024\005 \023\030\036\007\024\023\036\030\ \026\006\017\024\027\027\024\005 \216\214\230 \026)Tj /Span<>> BDC ( )Tj EMC (\f\004\036\021 \002\024\035\034\001\036\005 )Tj 0.338 Tw T* (\004\026\f\021\024\021\t \023\024\035\027\t\b \022\035\017\027\017\004\036\ \f\022\017\b \017)Tj /Span<>> BDC ( )Tj EMC (\023\026\021\024\n\024\030\235\024\035\024\020\017\004\036)Tj 0 Tw (-)Tj T* (\f\022\017\b \024\021\r\036\021\024\r.)Tj /T1_3 1 Tf 0.023 Tw 0 -2.436 TD (\223\030\032\255\020\034\036 \032\026\020\017\022\017\026)Tj /T1_1 1 Tf 0.517 Tw 0 -1.218 TD [(\025)-4.1(\024)-4.3(\027)1.7(\006)-6(\036)-6.8(\023)2.2(\006)-6(\017)-5.4(\016 \017)]TJ /Span<>> BDC ( )Tj EMC [(\007)-6(\017)2.7()-9.9(\026\005)1.7(\027 \017)-2.4(\f)3.1(\f)-38.9(\035)-6.8(\036)-19(\007)-4.4(\024)-4.3(\r)-8.9(\026\027)1.7(\017)-5.4(\016)13.7(:)]TJ /T1_4 1 Tf -0.029 Tc 0.546 Tw [( \207)-27.4(\020)-9.7(\006)-25.2(\031)-22.4(\027)]TJ /Span<>> BDC 19.578 0 Td ( )Tj EMC [(\207)-31.1(.\215.)-21.2(,)-29( )]TJ 0 Tc 0 Tw -19.578 -1.218 Td [(\224)12.2(\031)-0.9(\032)5.4(\021)7.7(\020)9.6(\001)3.3(\n)9.7(\027)]TJ /Span<>> BDC ( )Tj EMC [(\207)-2(.)28.5(\216)24.3(.)7.8(, )8.8(\n)5.3(\021)3.9(\n)2.4(\003)6.9(\026)1.8(\032\031)2.3(\021)10.7(\013)9.8(\n)]TJ /Span<>> BDC ( )Tj EMC [(\201)-2.3(.)7.4(\201)-2.3(.)7.8(, \212)23.8(\020)1.7(\005)4.7(\026)4.8(\013)9.8(\n)9.7(\027)]TJ /Span<>> BDC ( )Tj EMC [(\036)22.8(.)29.3(\210)122(.)]TJ /T1_1 1 Tf T* [(\221)-4.6(\002)-9.9(\024)0.7(\030 \017)]TJ /Span<>> BDC ( )Tj EMC [(\024)-11.8(\002)3(\030)-11.3(\026)-6.4(\002)-9.8(\024)-10.9(\021)-17.7(\022)-19.1(\026 \n)1.3(\026)-11.8(\021)-9.9(\036)-1.7(\030)-7.6(\017)-0.6(\026)-33.1(\035)-2.5(\024)-4.3(\r)10.4(:)]TJ /T1_4 1 Tf -0.029 Tc 0.029 Tw [( \207)-27.4(\020)-9.6(\006)-25.2(\031)-22.5(\027)]TJ /Span<>> BDC 15.383 0 Td ( )Tj EMC [(\207)-31.1(.\215.)]TJ /T1_1 1 Tf 0.018 Tc 2.016 Tw -15.383 -1.218 Td [(\221)35.2(\021)-3.5(\026)6.2(\021\017)15.6(\f)-18(\021\017)22.5(\004)9.8(\036)7.6(\f)16.4(\022)-1.1(\026)-3(\016)18( \024)6.2(\002)21(\030)6.6(\026)11.7(\002)8.1(\024)7.1(\021\022)-1.1(\026)21.8(:)]TJ /T1_4 1 Tf -0.029 Tc 2.063 Tw 13.383 0 Td [( \207)-27.4(\020)-9.7(\006)-25.2(\031)-22.4(\027)]TJ /Span<>> BDC 4.678 0 Td ( )Tj EMC [(\207)-31.1(.\215.)-21.2(,)-29( )]TJ -0.002 Tc 0.002 Tw -18.061 -1.218 Td [()6.8(\n)3.3(\021)1.8(\n\003)5(\026\032)-1.9(\031\021)8.7(\013)7.8(\n)]TJ /Span<>> BDC 5.387 0 Td ( )Tj EMC [(\201)-4.3(.)5.3(\201)-4.3(.)]TJ /T1_1 1 Tf 0.002 Tc -0.002 Tw -5.387 -1.218 Td [(\203)7.2(\026\023)4.2(\017\f)-10.8(\026)1.7(\027)3.7(\017)-6.7(\036)2.1( \021)-7.9(\036)-3.4(\022\f)-34(\021)-19.5(\026)5.7(:)]TJ /T1_4 1 Tf 0 Tc 0 Tw 7.694 0 Td [( \207)1.6(\020)19.3(\006)3.8(\031)6.6(\027)]TJ /Span<>> BDC ( )Tj EMC [(\207)-2(.)29.3(\215)28.8(.)7.8(, \201)-17.3(\023)3.3(\031)2.8(\013)9.4(\t)9.8(\031)-0.9(\031)6.6(\027)]TJ /Span<>> BDC ( )Tj EMC [(\240)19.4(.)28.5(\216)24.3(.)]TJ /T1_1 1 Tf -7.694 -1.218 Td [(\217)5.5(\036)-19(\007)-20.1(\026\022)-32.6(\021)-17.7(\017)1.5(\030)-11.8(\024)-4.4(\r)-8.8(\026\027)1.8(\017)-8.7(\036)6.5(:)]TJ /T1_4 1 Tf -0.01 Tc 0.01 Tw [( \212)13.8(\020)-8.3(\005)-5.3(\026)-5.1(\013\n\027)]TJ /Span<>> BDC 10.842 0 Td ( )Tj EMC [(\036)12.8(.)19.3(\210)112.1(.)]TJ /T1_3 1 Tf 0 Tc 0.023 Tw 12.402 30.445 Td (AUTHORS CONTRIBUTION)Tj /T1_1 1 Tf 0.262 Tw 0 -1.218 TD [(C)-6.5(o)0.8(nce)-0.7(p)-12.3(t a)2.4(n)-4.6(d d)-5.5(e)-13.3(s)-16.6(i)3.3(g)1.1(n o)-2.2(f t)-16.7(h)-5.3(e s)-20(t)-12.8(ud)-10.9(y)-11.8(:)]TJ /T1_4 1 Tf -0.002 Tc 0.264 Tw [( S)3.6(e)-3.7(rg)-4.5(e)-4.5(y)]TJ /Span<>> BDC 17.701 0 Td ( )Tj EMC (I.)Tj /Span<>> BDC 1.125 0 Td ( )Tj EMC [(S)14.9(y)-1.6(che)-6(v)31.6(,)-2( )]TJ 0 Tc 0.572 Tw -18.826 -1.218 Td [(S)16.3(t)2.3(a)-0.8(n)6.2(i)11(s)9.3(l)3.3(a)-4.3(v)]TJ /Span<>> BDC ( )Tj EMC [(V)53.1(.)]TJ /Span<>> BDC ( )Tj EMC [(C)3.2(h)1.9(e)-1.7(r)-14.6(n)6.2(y)-1(s)9.7(h)1.8(ov)33.6(, A)3.6(l)4.8(ek)-17.5(s)4.9(e)-2.5(y)]TJ /Span<>> BDC ( )Tj EMC [(A)-12.6(.)]TJ /Span<>> BDC ( )Tj EMC [(P)25(on)1.9(om)4.3(ar)2.4(e)-2.5(n)7.5(k)12.9(o)-3.7(, )]TJ 0.001 Tc -0.001 Tw 0 -1.218 TD [(E)21.6(v)9.2(g)-1.5(e)-1.6(n)7.2(y)]TJ /Span<>> BDC 2.704 0 Td ( )Tj EMC (G.)Tj /Span<>> BDC 1.041 0 Td ( )Tj EMC [(R)-8(y)7.9(b)0.6(a)2.7(k)13.9(ov)]TJ /T1_1 1 Tf 0 Tc 1.014 Tw -3.745 -1.218 Td [(C)-6.5(o)-5.8(l)-19(l)-14.3(e)-9.4(c)-32.5(t)-37.3(i)3.2(o)0.8(n )0.5(a)2.4(n)-4.6(d )0.6(p)-3.8(r)-6(o)-7(ce)-13.3(s)-12.8(s)-16.6(i)7.1(n)-1.9(g )0.6(o)-2.2(f )0.5(t)-16.6(h)-5.3(e )0.5(m)1.8(a)-8.4(t)-15.1(e)-2.1(r)-48(i)5.1(a)-1.5(l)-22.5(:)]TJ /T1_4 1 Tf 0 Tw ( )Tj -0.002 Tc 0.002 Tw 0 -1.218 TD [(S)3.6(e)-3.7(rg)-4.5(e)-4.5(y)]TJ /Span<>> BDC 2.567 0 Td ( )Tj EMC (I.)Tj /Span<>> BDC 0.864 0 Td ( )Tj EMC [(S)14.9(y)-1.6(che)-5.9(v)]TJ /T1_1 1 Tf -0.007 Tc 1.591 Tw -3.43 -1.218 Td [(St)-34.7(a)-15.4(t)-44.4(i)-4.3(s)-27(t)-44.4(i)-1.8(c)-18.8(a)-8.5(l)-7( p)-10.8(r)-13(o)-14(c)-6.8(e)-20.3(s)-19.8(s)-23.6(in)-8.9(g)2(:)]TJ /T1_4 1 Tf -0.002 Tc 1.586 Tw 10.672 0 Td [( S)3.6(e)-3.7(rg)-4.5(e)-4.4(y)]TJ /Span<>> BDC 4.384 0 Td ( )Tj EMC (I.)Tj /Span<>> BDC 2.448 0 Td ( )Tj EMC [(S)14.9(y)-1.6(che)-6(v)31.6(,)-2( )]TJ 0 Tc 0 Tw -17.504 -1.218 Td [(A)3.6(l)4.8(ek)-17.5(s)4.9(e)-2.5(y)]TJ /Span<>> BDC ( )Tj EMC [(A)-12.5(.)]TJ /Span<>> BDC ( )Tj EMC [(P)25(on)1.9(om)4.3(ar)2.4(e)-2.6(n)7.5(k)12.9(o)]TJ /T1_1 1 Tf -0.011 Tw 0 -1.218 TD [(W)3.1(r)-48(i)-6(t)-37.4(i)7.1(n)-1.9(g )0.5(o)-2.2(f )0.5(t)-16.7(h)-5.2(e t)-15.2(e)-23.8(x)-36(t)-20.1(:)]TJ /T1_4 1 Tf [( )0.5(S)5.6(e)-1.7(r)2.3(g)-2.5(e)-2.5(y)]TJ /Span<>> BDC ( )Tj EMC 10.889 0 Td [(I)2.4(.)]TJ /Span<>> BDC ( )Tj EMC 0.852 0 Td [(S)16.9(yc)1.8(h)1.9(e)-4(v)33.6(, )0.5(M)10.5(i)7.9(k)5.3(h)4.9(a)-2(i)7.4(l)]TJ /Span<>> BDC ( )Tj EMC 6.053 0 Td [(V)53.1(.)]TJ /Span<>> BDC ( )Tj EMC 0.943 0 Td [(A)3.6(l)4.8(ek)-17.5(s)4.9(e)-6.1(e)-4(v)]TJ /T1_1 1 Tf 0.006 Tc -0.006 Tw -18.738 -1.218 Td [(E)11.6(dit)-31.4(i)13.1(n)4.1(g)15(:)]TJ /T1_4 1 Tf 0.001 Tc -0.001 Tw 3.238 0 Td [( E)21.6(v)9.2(g)-1.5(e)-1.5(n)7.2(y)]TJ /Span<>> BDC 2.937 0 Td ( )Tj EMC (G.)Tj /Span<>> BDC 1.041 0 Td ( )Tj EMC [(R)-8(y)7.9(b)0.6(a)2.7(k)13.9(ov)]TJ /T1_3 1 Tf 0 Tc 0.023 Tw -7.216 -2.436 Td (\255\026\036\031\036\025\034\224 \017\225 \032\026\020\017\022\032\221 \(\ ORCID\))Tj /T1_1 1 Tf 0 Tw T* (\221\t\004\036\r)Tj /Span<>> BDC ( )Tj EMC (\221.\222.)Tj /Span<>> BDC ( )Tj EMC [(\227 0)-15.9(0)-16(0)-16(0)-40(-)-24(0)-15.9(0)-16(0)25(2-2)30(5)30(3)31(4-)64(7)40(9)25(2X)]TJ T* (\223\036\030\027\t\001\024\r)Tj /Span<>> BDC ( )Tj EMC (\221.\200.)Tj /Span<>> BDC ( )Tj EMC [(\227 0)-15.9(0)-16(0)-16(0)-40(-)-23.9(0)-16(0)-16(0)25(2-6)30(2)107(1)72(2-)-32(9)37(4)19.9(5)43(4)]TJ T* (\215\024\027\024\n\026\030\036\027\022\024)Tj /Span<>> BDC ( )Tj EMC (\202.\202.)Tj /Span<>> BDC ( )Tj EMC [(\227 0)-15.9(0)-16(0)-16(0)-39.9(-)-24(0)-16(0)-16(0)72(1)56(-)64(7)101(2)30(9)40(3-)88(1)40(8)20(5)20(9)]TJ T* (\202\035\036\022\f\036\036\r)Tj /Span<>> BDC ( )Tj EMC (\204.\200.)Tj /Span<>> BDC ( )Tj EMC [(\227 0)-15.9(0)-16(0)-16(0)-40(-)-23.9(0)-16(0)-16(0)72(1)56(-5)15(6)30(5)20(5-6)30(5)15(6)78(7)]TJ T* [(\217\t\002)15(\026\022\024\r)]TJ /Span<>> BDC ( )Tj EMC (\213.\202.)Tj /Span<>> BDC ( )Tj EMC [(\227 0)-15.9(0)-16(0)-16(0)-40(-)-23.9(0)-16(0)-16(0)25(2-)40(3)20(9)95(1)71.9(9-)-31.9(9)-24(06)78(7)]TJ /T1_3 1 Tf 0.023 Tw 0 -2.436 TD (INFORMATION ABOUT THE AUTHORS \(ORCID\))Tj /T1_1 1 Tf 0 Tw 0 -1.218 TD [(Ser)-32(ge)-11(y I. Sychev)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0002-2534-792X)Tj T* [(S)15(t)15(anisl)-16(av V. Cher)-14.9(ny)-12.9(shov)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0002-6212-9454)Tj T* [(Alek)-10(se)-10.9(y A. P)10(onomar)-23.9(enko)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0001-7293-1859)Tj T* [(Mikhail V. Alek)-9.9(seev)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0001-5655-6567)Tj T* [(Ev)-21(geny G. R)-19.9(ybakov)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0002-3919-9067)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 42.5896 383.8459 Tm [(\r\031\024\034\033)48(\026)45(\024)-10(\223\033)48(\026)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0 Tc 0.258 Tw 8 0 0 8 42.5197 371.0112 Tm (1.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (\025\035\017\027\017\004\036\f\022\017\036 \030\036\022\024\n\036\027\007\ \026\006\017\017. \217\026\022 \023\030\016\n\024\005 \022\017\001\022\017\ . \217\024\f\f\017\005\f\022\024\036 )Tj 0.017 Tc 0.633 Tw -1.296 -1.25 Td [(\210\002\013\036\f\021\r\024 \025\035\017\027\017\004\036\f\022\024\005 \ \210\027\022\024\035\024\020\017\017, \202\f\f\024\006\017\026\006\017\016\ \210\027\022\024\035\024\020\024\r)17( )]TJ 0 Tc 0.105 Tw 0 -1.25 TD (\217\024\f\f\017\017, \217\024\f\f\017\005\f\022\024\036 \210\002\013\036\ \f\021\r\024 \221\023\036\006\017\026\035\017\f\021\024\r \215\024)Tj /Span<>> BDC ( )Tj EMC (\025\024\035\024\030\036\022\021\026\035\034\027\024\n\031 )Tj 0.267 Tw T* [(\217\026\022\031, )0.5(\210\002\013\036\030\024\f\f\017\005\f\022\026\016 )0.5(\210\002\013\036\f\021\r\036\027\027\026\016 )0.6(\210\030\020\026\027\017\026\006\017\016 )0.5(\253\202\f\f\024\006\017\026\006\017\016 )]TJ 0.023 Tw T* (\025\024\035\024\023\030\024\022\021\024\035\024\020\024\r \217\024\f\f\017\ \017\273. 2022;78.)Tj -0.113 Tw T* (2.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Bosse)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(JF, Colle)-12(t)-30(te)]TJ /Span<>> BDC ( )Tj EMC [(L, Cal)-16(ais)]TJ /Span<>> BDC ( )Tj EMC [(G, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Chemo)17(t)-13(her)-33(apy wi)-24(t)-13(h P)35(r)-24(eoper)-32.9(a)15(t)-32(i)-16(ve )]TJ -0.016 Tw -1.296 -1.25 Td [(R)-10(adio)17(t)-13(her)-32.9(apy in R)13(ec)-16(t)15(al Cancer. )]TJ /T1_4 1 Tf [(N Eng)13(l J Med. )]TJ /T1_1 1 Tf 0 Tw (2006;355\(11\):1114\22623. )Tj T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td [(10.1056/NEJM)-23.9(oa060829)]TJ 0 0 0 1 k /GS1 gs 0.039 Tw -1.847 -1.25 Td (3.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Goll)-31(ins)]TJ /Span<>> BDC ( )Tj EMC [(S, Seba)-17(g-M)-24(ontef)-27.9(ior)-24(e)]TJ /Span<>> BDC ( )Tj EMC [(D. Neoad)17(juv)-15(ant T)50(r)-24(ea)15(tment S)15(tr)-32.9(a)15(tegies )]TJ 0.094 Tw -1.296 -1.25 Td [(for L)35(o)-16(call)35(y A)15(d)-17(v)-15(anced R)13(ec)-16(t)15(al Cancer. )]TJ /T1_4 1 Tf (Clin Oncol)Tj /T1_1 1 Tf (. 2016;28\(2\):146\22651. )Tj 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td [(10.1016/j.cl)30.1(on.2015.11.003)]TJ 0 0 0 1 k /GS1 gs 0.137 Tw -1.847 -1.25 Td (4.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (Xiao)Tj /Span<>> BDC ( )Tj EMC (TX, Hou)Tj /Span<>> BDC ( )Tj EMC (WY, Mei)Tj /Span<>> BDC ( )Tj EMC [(S)-10(W, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Sur)-31.9(v)-16(i)-16(v)-15(al anal)35(y)-13(sis of ear)-30(l)35(y-onse)-12(t )]TJ 0.126 Tw -1.296 -1.25 Td [(l)30(o)-16(call)35(y ad)-17(v)-14.9(anced r)-24(ec)-16(t)15(al cancer: a r)-24(e)-12(tr)-31.9(ospec)-16(t)-32(i)-16(ve stud)17.1(y based on t)-12.9(he )]TJ 0.137 Tw T* [(Sur)-32(veill)-15.9(ance, Epidemiol)30.1(o)-16(g)16(y, and End R)13(esul)56.1(ts \(SEER\) d)42(a)15(t)15(abase. 2023 )]TJ 0.023 Tw T* [(Jan;26\(1\):75\22683. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.3760/cma.j.cn441530-20220704-00291)Tj 0 0 0 1 k /GS1 gs 0.165 Tw T* (5.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(P)30(ee)-12(ter)-9.9(s K)20(CMJ, Mar)-37(ijnen)]TJ /Span<>> BDC ( )Tj EMC [(C)20(AM, Na)-17(g)17(tegaal)]TJ /Span<>> BDC ( )Tj EMC [(ID, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. T)47(he TME tr)-37(ial )]TJ 0.239 Tw -1.296 -1.25 Td [(af)-28(ter a median foll)30.1(o)-14(w-up of 6 year)-9.9(s: incr)-24(eased l)30(o)-16(cal contr)-32(ol but )]TJ 0.282 Tw T* [(no sur)-31.9(v)-16(i)-16(v)-15(al benef)-28(i)-24(t in ir)-24(r)-32.9(adia)15(ted p)32(a)15(t)-32(ients wi)-24(t)-12.9(h r)-24(esec)-16(t)15.1(able r)-24(ec)-15.9(t)15(al )]TJ 0 Tw T* [(car)-32(c)-24(inoma. )]TJ /T1_4 1 Tf 0.133 Tw 4.852 0 Td (Ann Surg.)Tj /T1_1 1 Tf [( 2007 N)-14(ov;246\(5\):693\226701. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1097/01.)Tj -4.852 -1.25 Td [(sl)-16(a.0000257358.56863.ce)]TJ 0 0 0 1 k /GS1 gs 0.335 Tw T* (6.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Mar)-22(t)-32(in)]TJ /Span<>> BDC ( )Tj EMC [(S)-21(T, Heneghan)]TJ /Span<>> BDC ( )Tj EMC [(HM, W)-16(inter)]TJ /Span<>> BDC ( )Tj EMC [(DC. Sy)-13(stema)15.1(t)-32(ic r)-23.9(ev)-16(iew and )]TJ -0.001 Tw -1.296 -1.25 Td [(me)-12(t)15(a-anal)35.1(y)-13(sis of outcomes foll)30.1(o)-14(wing p)32(a)15(t)-12.9(hol)30(o)-16(gical com)10(ple)-11.9(te r)-24(esponse )]TJ 0.297 Tw T* [(t)17(o neoad)17(juv)-15(ant chemor)-33(adio)17(t)-13(her)-32.9(apy for r)-24(ec)-15.9(t)15(al cancer. )]TJ /T1_4 1 Tf (Br J Surg)Tj /T1_1 1 Tf 0 Tw (. )Tj 0.023 Tw T* [(2012;99\(7\):918\22628. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1002/bjs.8702)Tj 0 0 0 1 k /GS1 gs 0.023 Tw [( Epub 2012 F)10(eb 23.)]TJ -0.095 Tw T* (7.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Z)25(or)-32(col)30(o)]TJ /Span<>> BDC ( )Tj EMC [(L, R)11(os)26(man)]TJ /Span<>> BDC ( )Tj EMC [(A)35(S, R)13(est)-32(i)-16(vo)]TJ /Span<>> BDC ( )Tj EMC [(A, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Com)10(ple)-11.9(te p)32(a)15(t)-13(hol)30(o)-16(gic r)-23.9(esponse )]TJ 0.102 Tw -1.296 -1.25 Td [(af)-28(ter combined mod)42(al)-31(i)-24(t)-10(y tr)-24(ea)15.1(tment for r)-24(ec)-15.9(t)15(al cancer and l)30(ong-ter)-16(m )]TJ 0.32 Tw T* [(sur)-32(v)-16(i)-15.9(v)-15(al: A me)-12(t)15(a-anal)35(y)-12.9(sis. )]TJ /T1_4 1 Tf (Ann Surg Oncol)Tj /T1_1 1 Tf (. 2012;19\(9\):2822\22632. )Tj 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1245/s10434-011-2209-y)Tj 0 0 0 1 k /GS1 gs 0.054 Tw -1.847 -1.25 Td (8.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Y)40(oen)]TJ /Span<>> BDC ( )Tj EMC [(H, P)40(ar)-23.9(k)]TJ /Span<>> BDC ( )Tj EMC (HE, Kim)Tj /Span<>> BDC ( )Tj EMC [(SH, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. P)35(r)-32(o)-16(gnost)-32(ic v)-15(al)35(ue of tumor r)-24(egr)-23.9(es)]TJ 0 Tw (-)Tj 0.315 Tw -1.296 -1.25 Td [(sion gr)-33(ade on MR in r)-24(ec)-16(t)15.1(al cancer: A l)-16(ar)-32(ge-scale, single-center )]TJ 0 Tw 29.055 36.25 Td [(e)-18(xper)-36.9(ience. )]TJ /T1_4 1 Tf 0.267 Tw 5.214 0 Td [(K)18(orean )0.5(J )0.5(R)20(adiol. )]TJ /T1_1 1 Tf 7.395 0 Td [(2020;21\(9\):1065\22676. )0.5(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw 11.289 0 Td (10.3348/)Tj -23.899 -1.25 Td (kjr.2019.0797)Tj 0 0 0 1 k /GS1 gs 0.262 Tw T* (9.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Co)14(x)]TJ /Span<>> BDC ( )Tj EMC [(JD, S)15(te)-12(tz)]TJ /Span<>> BDC ( )Tj EMC [(J)15(A, P)40(ajak)]TJ /Span<>> BDC ( )Tj EMC [(TF. T)45(o)14(xic)-24(i)-24(t)-10(y cr)-37(i)-23.9(ter)-37(ia of t)-13(he R)-10(adia)15(t)-32(ion )]TJ 0.102 Tw -1.296 -1.25 Td [(T)47(her)-33(apy Oncol)30(o)-16(g)16(y G)20(r)-32(oup \(R)-12(T)20(OG\) and t)-12.9(he Eur)-31.9(opean or)-32(ganiza)15.1(t)-32(ion for )]TJ 0.158 Tw T* [(r)-24(esear)-31.9(ch and tr)-23.9(ea)15(tment of cancer \(EOR)-11.9(T)34.9(C\). )]TJ /T1_4 1 Tf [(Int J R)20(adiat Oncol Biol )]TJ 0 Tw T* [(Ph)12(ys.)]TJ /T1_1 1 Tf 0.023 Tw [( 1995;31\(5\):1341\2266. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1016/0360-3016\(95\)00060-C)Tj 0 0 0 1 k /GS1 gs -0.055 Tw T* (10.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Cancer T)47(her)-33(apy Ev)-15(al)35(ua)15(t)-32(ion P)35(r)-32(o)-16(gr)-33(am \(CTEP\). Common T)40(er)-16(minol)30(o)-16(g)16(y )]TJ -0.032 Tw -1.796 -1.25 Td [(Cr)-37(i)-23.9(ter)-37(ia for A)15(d)-17(ver)-10(se Events \(CT)35(C)20(AE\).v.5.0 [5x7]. )]TJ /T1_4 1 Tf [(Cancer Ther Ev)16(al Prog)14(r)]TJ /T1_1 1 Tf 0 Tw ( )Tj 0.099 Tw T* [([Inter)-15(ne)-11.9(t]. 2017;155. A)15(v)-15(ail)-15.9(able fr)-32(om: ht)-29.9(tps://c)-16(tep.cancer.gov/p)25.1(r)-32(o)]TJ 0 Tw (-)Tj T* [(t)17(o)-16(colDevel)30.1(opment/elec)-16(tr)-31.9(onic_appl)-31(ica)15(t)-32(ions/c)-15.9(tc.htm#c)-16(tc_50)]TJ -0.051 Tw T* (11.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Heald)Tj /Span<>> BDC ( )Tj EMC [(RJ, M)-24(or)-33(an)]TJ /Span<>> BDC ( )Tj EMC [(BJ, R)-20(y)22(all)]TJ /Span<>> BDC ( )Tj EMC [(RD, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. R)13(ec)-16(t)15(al cancer: t)-12.9(he Basingst)17.1(ok)9.9(e )]TJ 0.035 Tw -1.796 -1.25 Td [(e)-18(xper)-36.9(ience of t)17(o)17(t)15(al mesor)-24(ec)-16(t)15(al e)-18(x)-12.9(c)-24(ision, 1978-1997. )]TJ /T1_4 1 Tf (Arch Surg.)Tj /T1_1 1 Tf ( 1998 )Tj 0.023 Tw T* [(A)10(ug;133\(8\):894\2269. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw [(10.1001/ar)-32(chsur)-31.9(g.133.8.894)]TJ 0 0 0 1 k /GS1 gs 0.131 Tw T* (12.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Cam)10(p)32(a-T)47(hom)10(pson)]TJ /Span<>> BDC ( )Tj EMC [(M, W)22(eir)]TJ /Span<>> BDC ( )Tj EMC [(R, Cal)16(ce)-12(ter)-33(a)]TJ /Span<>> BDC ( )Tj EMC [(N, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. P)40(a)15(t)-13(hol)30(o)-16(gic p)24.9(r)-31.9(o)]TJ 0 Tw (-)Tj 0.018 Tw -1.796 -1.25 Td [(cessing of t)-13(he t)17(o)17(t)15.1(al mesor)-23.9(ec)-16(t)15(al e)-18(x)-12.9(c)-24(ision. )]TJ /T1_4 1 Tf [(Clin Colon R)21(ectal Surg.)]TJ /T1_1 1 Tf ( 2015 )Tj 0.023 Tw T* [(Mar;28\(1\):43\22652. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1055/s-0035-1545069)Tj 0 0 0 1 k /GS1 gs 0.183 Tw T* (13.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Amin)Tj /Span<>> BDC ( )Tj EMC [(MB, G)20(r)-24(eene)]TJ /Span<>> BDC ( )Tj EMC (FL, Edge)Tj /Span<>> BDC ( )Tj EMC [(SB, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. T)47(he Eight)-13(h Edi)-23.9(t)-32(ion AJCC )]TJ 0.124 Tw -1.796 -1.25 Td [(Cancer S)15(t)15(a)-17(ging Manual: )0.5(Cont)-32(inuing t)17(o build a br)-37(idge fr)-32(om a popu)]TJ 0 Tw (-)Tj 0.117 Tw T* [(l)-16(a)15(t)-32(ion-based t)17(o a mor)-24(e \231per)-10(sonal)-31(ized\232 app)25(r)-32(oa)-17(ch t)17(o cancer st)15(a)-17(ging. )]TJ /T1_4 1 Tf 0.295 Tw T* [(C)-18(A: a cancer jour)-14(nal for clinicians. U)22(nited S)28(tates.)]TJ /T1_1 1 Tf ( 2017;67:93\2269. )Tj 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td [(10.3322/caa)-17(c.21388)]TJ 0 0 0 1 k /GS1 gs 0.017 Tw -1.847 -1.25 Td (14.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(R)-20(y)22(an)]TJ /Span<>> BDC ( )Tj EMC 2.201 0 Td [(JE, )0.5(W)12(ar)-24(r)-36.9(ier)]TJ /Span<>> BDC ( )Tj EMC 4.525 0 Td [(SK, )0.5(L)70(ynch)]TJ /Span<>> BDC ( )Tj EMC 3.959 0 Td [(A)16(C, )0.5(e)-12(t)]TJ /Span<>> BDC ( )Tj EMC 2.52 0 Td [(al. )0.5(Assessing )0.6(p)32(a)15(t)-13(hol)30(o)-16(gical )0.5(com)]TJ 0 Tw (-)Tj -0.072 Tw -15.001 -1.25 Td [(ple)-12(te r)-24(esponse t)17(o neoad)17(juv)-15(ant chemor)-33(adio)17(t)-13(her)-32.9(apy in l)30.1(o)-16(call)35(y ad)-17(v)-14.9(anced )]TJ -0.032 Tw T* [(r)-24(ec)-15.9(t)15(al cancer: a sy)-13(stema)15(t)-32(ic r)-24(ev)-16(iew. )]TJ /T1_4 1 Tf [(Color Dis Of)-39.9(f J Assoc Colop)46(roctology )]TJ 0.023 Tw T* [(Gt Br)-36.9(itain Irel. )]TJ /T1_1 1 Tf [(2015 O)-16(c)-16(t;17\(10\):849\22661. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1111/codi.13081)Tj 0 0 0 1 k /GS1 gs 0.176 Tw T* (15.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Dind)-16(o)]TJ /Span<>> BDC ( )Tj EMC [(D, Demar)-22(t)-32(ines)]TJ /Span<>> BDC ( )Tj EMC [(N, Cl)-16(av)-16(ien P-A. Cl)-15.9(assif)-28(ica)15(t)-32(ion of sur)-32(gical )]TJ 0.102 Tw -1.796 -1.25 Td [(com)10(pl)-31(ica)15.1(t)-32(ions: a new p)25(r)-32(oposal wi)-24(t)-12.9(h ev)-15(al)35(ua)15(t)-32(ion in a cohor)-22(t of 6336 )]TJ 0.006 Tw T* [(p)32(a)15(t)-32(ients and r)-24(esul)56.1(ts of a sur)-32(ve)-10.9(y. )]TJ /T1_4 1 Tf (Ann Surg.)Tj /T1_1 1 Tf [( 2004 A)10(ug;240\(2\):205\22613. )]TJ 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td [(10.1097/01.sl)-15.9(a.0000133083.54934.ae)]TJ 0 0 0 1 k /GS1 gs 0.043 Tw -1.847 -1.25 Td (16.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(R)-10(ahbar)-37(i)]TJ /Span<>> BDC ( )Tj EMC [(NN, W)22(ei)-23.9(tz)]TJ /Span<>> BDC ( )Tj EMC [(J, Hohenber)-32(ger)]TJ /Span<>> BDC ( )Tj EMC [(W, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Def)-28(ini)-24(t)-31.9(ion and gr)-32.9(ad)]TJ 0 Tw (-)Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\021\032)50(\b)42(\032\231\027 \213\036)30.1(\005\t\033)30(\b)]TJ 52.896 0 Td (LEADING ARTICLE)Tj /T1_5 1 Tf 25 0 0 25 512.002 56.0378 Tm (19)Tj ET endstream endobj 2547 0 obj <>/Border[0 0 0]/H/N/Rect[57.2978 308.307 136.625 299.011]/Subtype/Link/Type/Annot>> endobj 2548 0 obj <>/Border[0 0 0]/H/N/Rect[57.2978 278.307 148.393 269.011]/Subtype/Link/Type/Annot>> endobj 2549 0 obj <>/Border[0 0 0]/H/N/Rect[116.404 238.307 255.531 229.011]/Subtype/Link/Type/Annot>> endobj 2550 0 obj <>/Border[0 0 0]/H/N/Rect[223.342 198.307 263.622 188.851]/Subtype/Link/Type/Annot>> endobj 2551 0 obj <>/Border[0 0 0]/H/N/Rect[42.5197 188.307 125.871 179.011]/Subtype/Link/Type/Annot>> endobj 2552 0 obj <>/Border[0 0 0]/H/N/Rect[124.94 148.307 182.563 139.011]/Subtype/Link/Type/Annot>> endobj 2553 0 obj <>/Border[0 0 0]/H/N/Rect[57.2978 108.307 150.329 99.0112]/Subtype/Link/Type/Annot>> endobj 2554 0 obj <>/Border[0 0 0]/H/N/Rect[466.151 378.307 496.063 368.851]/Subtype/Link/Type/Annot>> endobj 2555 0 obj <>/Border[0 0 0]/H/N/Rect[274.961 368.307 320.024 359.011]/Subtype/Link/Type/Annot>> endobj 2556 0 obj <>/Border[0 0 0]/H/N/Rect[376.223 328.307 481.422 318.851]/Subtype/Link/Type/Annot>> endobj 2557 0 obj <>/Border[0 0 0]/H/N/Rect[353.877 258.307 447.052 249.011]/Subtype/Link/Type/Annot>> endobj 2558 0 obj <>/Border[0 0 0]/H/N/Rect[348.94 228.307 431.596 219.011]/Subtype/Link/Type/Annot>> endobj 2559 0 obj <>/Border[0 0 0]/H/N/Rect[289.739 178.307 356.554 169.011]/Subtype/Link/Type/Annot>> endobj 2560 0 obj <>/Border[0 0 0]/H/N/Rect[422.26 138.307 488.268 128.851]/Subtype/Link/Type/Annot>> endobj 2561 0 obj <>/Border[0 0 0]/H/N/Rect[289.739 98.3073 413.578 89.0112]/Subtype/Link/Type/Annot>> endobj 2576 0 obj <> endobj 2575 0 obj <> endobj 2574 0 obj <> endobj 2573 0 obj <> endobj 2572 0 obj <> endobj 2571 0 obj <> endobj 2570 0 obj <> endobj 2569 0 obj <> endobj 2568 0 obj <> endobj 2567 0 obj <> endobj 2566 0 obj <> endobj 2565 0 obj <> endobj 2564 0 obj <> endobj 2563 0 obj <> endobj 2562 0 obj <> endobj 2488 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.086 Tw 10 0 0 10 70.8661 724.8299 Tm (11\) \022\024\005\022\024-\007\027\036\005 \017)Tj /Span<>> BDC ( )Tj EMC (9 \(7, 12\))Tj /Span<>> BDC ( )Tj EMC (\227 \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \216\214\230 \()Tj /T1_1 1 Tf 0 Tw (\032)Tj /T1_0 1 Tf 0.086 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,6\) )Tj 0 Tw 0 -1.218 TD (\(\230\026\002\035. 4\).)Tj /T1_1 1 Tf 0 -2.436 TD (\212\031\016\205\023\022\024\026\024\020 \033\026\024\n\003\n\032\f\n\023\ \n\202\025\006\031\t\013\n\202\n \025\t\t\023\031\030\n\027\026\021\025\002\ )Tj /T1_0 1 Tf 0.575 Tw 0 -1.218 TD (\215\024 \007\026\027\027\t\n \023\026\021\024\n\024\030\235\024\035\024\ \020\017\004\036\f\022\024\020\024 \017\f\f\035\036\007\024\r\026\027\017\ \016 )Tj 0.214 Tw T* (\031\007\026\035\036\027\027\t\b \n\026\022\030\024\023\030\036\023\026\030\ \026\021\024\r \004\026\f\021\024\021\026 \023\024\035\027\024\020\024 \023\ \026\021\024)Tj 0 Tw (-)Tj 0.249 Tw 0 -1.218 TD (\n\024\030\235\024\035\024\020\017\004\036\f\022\024\020\024 \024\021\r\036\ \021\026 \023\024)Tj /Span<>> BDC ( )Tj EMC [(\001\022\026\035\036 R)-19.9(y)22(an \r)]TJ /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 )Tj -0.04 Tw 0 -1.218 TD (\230\203\230 \f\024\f\021\026\r\017\035\026 20% \(9/45\) \r)Tj /Span<>> BDC ( )Tj EMC (\f\030\026\r\027\036\027\017\017 \f)Tj /Span<>> BDC ( )Tj EMC (8% \(5/62\))Tj /Span<>> BDC ( )Tj EMC (\227 )Tj -0.006 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \216\214\230 \()Tj /T1_1 1 Tf 0 Tw (\032)Tj /T1_0 1 Tf -0.006 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,06\). \223\026\f\021\024\021\026 R0 \030\036\036\022\006\017\005 \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 )Tj 0.149 Tw T* (\230\203\230 \f\024\f\021\026\r\017\035\026 91% \(41/45\) \023\030\024\021\ \017\r 89% \(57/62\))Tj /Span<>> BDC ( )Tj EMC (\227 )Tj 0.044 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC 0.75 0 Td [(\020\030\031\023\023\036 )0.6(\216\214\230 )0.6(\()]TJ /T1_1 1 Tf 0 Tw (\032)Tj /T1_0 1 Tf 0.044 Tw /Span<>> BDC ( )Tj EMC 5.988 0 Td (=)Tj /Span<>> BDC ( )Tj EMC 0.776 0 Td [(0,9\). )0.6(\206\030\031\023\023\t )0.6(\027\036 )0.5(\030\026\035\017\004\026\035\017\f\034 )0.6(\023\024)]TJ /Span<>> BDC ( )Tj EMC 13.4 0 Td (\021\026)Tj 0 Tw (-)Tj 0.056 Tw -20.915 -1.218 Td (\022\017\n \023\026\030\026\n\036\021\030\026\n, \022\026\022 ypT \017)Tj /Span<>> BDC ( )Tj EMC (ypN \f\021\026\007\017\016, \023\036\030\017\027\036\r\030\026\035\034)Tj 0 Tw (-)Tj 0 -1.218 TD (\027\026\016 \017)Tj /Span<>> BDC ( )Tj EMC (\035\017\n\235\024\r\026\f\022\031\035\016\030\027\026\016 \017\027\r\026\ \017\016 \(\230\026\002\035.)Tj /Span<>> BDC ( )Tj EMC (5\).)Tj 0.29 Tw 0 -1.218 TD [(\230\026\022\017\n )0.5(\024\002\030\026\024\n, )0.6(\004\026\f\021\024\021\026 )0.5(\023\024\035\027\024\020\024 )0.5(\022\035\017\027\017\004\036\f\022\024\020\024 )0.6(\024\021)]TJ 0 Tw (-)Tj 0.218 Tw 0 -1.218 TD (\r\036\021\026 \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \f\024\f\021\026\r\017\035\026 17/53 \(32%\) \023\ \030\024\021\017\r 6/68 )Tj -0.025 Tw T* (\(9%\) \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \216\214\230, \030\026\035\017\004\017\016 \024\ \022\026\026\035\017\f\034 \f\021\026\021\017\f\021\017\004\036\f\022\017\ )Tj 0.079 Tw T* (\027\026\004\017\n\t \()Tj /T1_1 1 Tf 0 Tw (\032)Tj /T1_0 1 Tf 0.079 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,001\). \223\026\f\021\024\021\026 \023\024\035\027\024\020\024 \023\026\ \021\024\n\024\030\235\024\035\024)Tj 0 Tw (-)Tj 0.036 Tw T* (\020\017\004\036\f\022\024\020\024 \024\021\r\036\021\026 \031)Tj /Span<>> BDC ( )Tj EMC (\024\023\036\030\017\030\024\r\026\027\027\t\b \002\024\035\034\027\t\b \ \f\024\f\021\026\r\017)Tj 0 Tw (-)Tj 0.117 Tw T* (\035\026 8/36 \(22%\))Tj /Span<>> BDC ( )Tj EMC (\227 \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \230\203\230, \r)Tj /Span<>> BDC ( )Tj EMC (\f\030\026\r\027\036\027\017\017 \f)Tj /Span<>> BDC ( )Tj EMC (4/62 )Tj 0.081 Tw T* (\(7%\))Tj /Span<>> BDC ( )Tj EMC (\227 \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \216\214\230 \()Tj /T1_1 1 Tf 0 Tw (\032)Tj /T1_0 1 Tf 0.081 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,02\). \230\026\022\017\n \024\002\030\026\024\n, \024\002)Tj 0 Tw (-)Tj 0.058 Tw T* [(\013\026\016 \004\026\f\021\024\021\026 \023\024\035\027\t\b )0.5(\024\021\r\036\021\024\r \(\023\026\021\024\n\024\030\235\024\035\024\020\ \017\004\036\f\022\024\020\024 )]TJ 0.079 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\022\035\017\027\017\004\036\f\022\024\020\024\) \f\024\f\021\026\r\017\035\ \026 25/53 \(47%\))Tj /Span<>> BDC ( )Tj EMC (\227 \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 )Tj 0.056 Tw T* (\230\203\230, \023\030\024\021\017\r 10/68 \(15%\))Tj /Span<>> BDC ( )Tj EMC (\227 \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \216\214\230 \()Tj /T1_1 1 Tf 0 Tw (\032)Tj /T1_0 1 Tf 0.056 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,001\) )Tj 0 Tw T* (\(\230\026\002\035.)Tj /Span<>> BDC ( )Tj EMC (6\).)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 70.936 408.2018 Tm [(\037\036)10(\032\223\212\226\034\022\031\034)]TJ 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0 Tc 0.234 Tw 10 0 0 10 70.8661 383.8458 Tm [(\200 \024\023\031\002\035\017\022\024\r\026\027\027\t\b \030\026\027\036\ \036 \023\030\036\007\r\026\030\017\021\036\035\034\027\t\b )0.5(\030\036\031\035\034)]TJ 0 Tw (-)Tj 0.348 Tw T* [(\021\026\021\026\b \002\t\035\026 \023\030\024\007\036\n\024\027\f\021\030\ \017\030\024\r\026\027\026 )0.5(\002\036\024\023\026\f\027\024\f\021\034 )0.5(\021\024)]TJ 0 Tw (-)Tj 0.314 Tw T* (\021\026\035\034\027\024\005 \027\036\024\026\007\255\033\r\026\027\021\027\ \024\005 \021\036\030\026\023\017\017 \r)Tj /Span<>> BDC ( )Tj EMC (\035\036\004\036\027\017\017 \030\026\022\026 )Tj 0.267 Tw T* [(\023\030\016\n\024\005 )0.5(\022\017\001\022\017 )0.6([17]. )0.5(\215\024)]TJ /Span<>> BDC ( )Tj EMC 10.827 0 Td [(\026\r\036\030\001\036\027\017\017 )0.6(\017\f\f\035\036\007\024\r\026\027\017\016 )]TJ 0.123 Tw -10.827 -1.218 Td (\002\t\035\024 \023\024\007\021\r\036\030\032\007\036\027\024, \004\021\024\ \023\030\017\n\036\027\036\027\017\036 \230\203\230 \027\036 \023\030\017\ \r\024)Tj 0 Tw (-)Tj 0.097 Tw T* (\007\017\021 \022)Tj /Span<>> BDC ( )Tj EMC (\f\021\026\021\017\f\021\017\004\036\f\022\017 \027\026\004\017\n\024\n\ \031 \031\r\036\035\017\004\036\027\017\033 \004\026\f\021\024\021\t )Tj 0.123 Tw T* [(\r\024\027\017\022\027\024\r\036\027\017\016 )0.5(\021\024\022\f\017\004\036\f\022\017\b \030\036\026\022\006\017\005 III-\ IV \f\021\036\023\036\027\017, )]TJ 0.166 Tw T* [(\022\024\021\024\030\026\016 )0.5(\002\t\035\026 )0.6(\024\021\n\036\004\036\027\026 )0.5(\021\024\035\034\022\024 )0.6(\r)]TJ /Span<>> BDC ( )Tj EMC 14.389 0 Td [(2/60 )0.5(\(3%\) )0.5(\027\026\002\035\033)]TJ 0 Tw (-)Tj 0.208 Tw -14.389 -1.218 Td (\007\036\027\017\016\b \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \230\203\230, \r)Tj /Span<>> BDC ( )Tj EMC (\f\030\026\r\027\036\027\017\017 \f)Tj /Span<>> BDC ( )Tj EMC (0/71 \(0%\))Tj /Span<>> BDC ( )Tj EMC (\227 )Tj 0.054 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \216\214\230 \()Tj /T1_1 1 Tf 0 Tw (\032)Tj /T1_0 1 Tf 0.054 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,9\). \217\026\r\027\t\n \024\002\030\026\024\n, \023\030\017\n\036\027\ \036\027\017\036 )Tj 0.088 Tw T* [(\021\024\021\026\035\034\027\024\005 \027\036\024\026\007\255\033\r\026\027\ \021\027\024\005 )0.5(\021\036\030\026\023\017\017 \027\036 \f\024\023\030\024\r\024\032\007\026\ )]TJ 0 Tw (-)Tj 0.195 Tw T* (\036\021\f\016 \f\021\026\021\017\f\021\017\004\036\f\022\017 \027\026\004\ \017\n\t\n \031\r\036\035\017\004\036\027\017\036\n \004\026\f\021\024\021\ \t )Tj 0.059 Tw T* [(\017\027\021\030\026- )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC 3.827 0 Td [(\023\024\f\035\036\024\023\036\030\026\006\017\024\027\027\t\b )0.6(\024\f\035\024\032\027\036\027\017\005. )0.6(\200)]TJ /Span<>> BDC ( )Tj EMC 15.232 0 Td (\007\026\027\027\024\n )Tj 0.225 Tw -19.059 -1.218 Td (\017\f\f\035\036\007\024\r\026\027\017\017 \007\024\f\021\017\020\027\031\ \021 \023\030\017\036\n\035\036\n\t\005 \031\030\024\r\036\027\034 \022\024\ \n)Tj 0 Tw (-)Tj 0.082 Tw T* (\023\035\026\036\027\021\027\024\f\021\017 \230\203\230: 51 \(85%\) \017\ )Tj /Span<>> BDC ( )Tj EMC (60 \023\026\006\017\036\027\021\024\r \023\030\024\001\035\017 )Tj 0.074 Tw T* [(\r\f\036 )0.5(3 )0.5(\026\023\035\026\027\017\030\024\r\026\027\027\t\b )0.5(\022\031\030\f\026 )0.6(\022\024\027\f\024\035\017\007\017\030\031\033\013\036\005 )0.6(\b\017)]TJ 0 Tw (-)Tj 0.158 Tw T* (\n\017\024\021\036\030\026\023\017\017, 7)Tj /Span<>> BDC ( )Tj EMC (\(12%\) \023\026\006\017\036\027\021\024\r \026\r\036\030\001\017\035\017\ 2 \022\031\030\f\026 )Tj 0.119 Tw T* (\b\017\n\017\024\021\036\030\026\023\017\017 \017)Tj /Span<>> BDC ( )Tj EMC (2)Tj /Span<>> BDC ( )Tj EMC (\(3%\) \023\026\006\017\036\027\021\026 \026\r\036\030\001\017\035\017 \ \021\024\035\034\022\024 )Tj 0.007 Tw T* (\024\007\017\027 \022\031\030\f. \210\007\027\026\022\024 \021\024\035\034\ \022\024 \r)Tj /Span<>> BDC ( )Tj EMC (\024\007\027\024\n \f\035\031\004\026\036 \b\017\n\017\024\021\036\030\026\ )Tj 0 Tw (-)Tj 0.053 Tw T* (\023\017\016 \002\t\035\026 \023\030\036\022\030\026\013\036\027\026 \023\ \024)Tj /Span<>> BDC ( )Tj EMC (\023\030\017\004\017\027\036 \030\026\r\017\021\017\016 \021\024\022\f\017\ \004\036)Tj 0 Tw (-)Tj T* (\f\022\017\b \030\036\026\022\006\017\005.)Tj 0.156 Tw T* (\210\006\036\027\022\031 \220\235\235\036\022\021\017\r\027\024\f\021\017\ \023\030\024\r\036\007\036\027\027\024\020\024 \027\036\024\026\007\255\ \033\r\026\027\021)Tj 0 Tw (-)Tj 0.454 Tw T* (\027\024\020\024 \035\036\004\036\027\017\016 \023\030\024\r\024\007\017\ \035\017 \023\031\021\036\n \026\027\026\035\017\026 \004\026\f\021\024\ \021\t )Tj 0.465 Tw T* [(\023\024\035\027\t\b \022\035\017\027\017\004\036\f\022\017\b )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC (\023\026\021\024\n\024\030\235\024\035\024\020\017\004\036\f\022\017\b \024\ \021)Tj 0 Tw (-)Tj 0.367 Tw T* (\r\036\021\024\r. \215\024\035\027\t\005 \023\026\021\024\n\024\030\235\024\ \035\024\020\017\004\036\f\022\017\005 \024\021\r\036\021 \023\024\f\035\ \036 )Tj 0.359 Tw T* (\027\036\024\026\007\255\033\r\026\027\021\027\024\005 \021\036\030\026\023\ \017\017 \016\r\035\016\036\021\f\016 \002\035\026\020\024\023\030\017\016\ \021\027\t\n )Tj 0.385 Tw 23.244 64.543 Td (\023\030\024\020\027\024\f\021\017\004\036\f\022\017\n \023\030\017\027\ \026\022\024\n. \230\026\022, \023\024)Tj /Span<>> BDC ( )Tj EMC (\007\026\027\027\t\n \n\036)Tj 0 Tw (-)Tj 0.426 Tw 0 -1.218 TD [(\021\026\026\027\026\035\017\026 Mar)-22(t)-32(in S.T. \017)]TJ /Span<>> BDC ( )Tj EMC (\f\024\026\r\021., \024\023\031\002\035\017\022\024\r\026\027\027\024\020\ \024 )Tj 0.243 Tw 0 -1.218 TD (\r)Tj /Span<>> BDC ( )Tj EMC (2012)Tj /Span<>> BDC ( )Tj EMC [(\020\024\007\031 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC [(\024\002\255\036\007\017\027\017\r\001\036\020\024 )0.5(\030\036\031\035\034\021\026\021\t )0.5(\035\036\004\036\027\017\016 )]TJ 0.076 Tw 0 -1.218 TD (\002\024\035\036\036 3000)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r, \024\002\013\026\016 \r\t\032\017\r\026\ \036\n\024\f\021\034 \031)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\034)Tj 0 Tw (-)Tj 0.17 Tw 0 -1.218 TD (\027\t\b \f)Tj /Span<>> BDC ( )Tj EMC (\023\024\035\027\t\n \023\026\021\024\n\024\030\235\024\035\024\020\017\004\ \036\f\022\017\n \024\021\r\036\021\024\n \002\024\035\034)Tj 0 Tw (-)Tj 0.065 Tw 0 -1.218 TD [(\001\036 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC [(\021\030\017 \030\026\026 )0.5(\(\210\234)]TJ /Span<>> BDC ( )Tj EMC 8.096 0 Td (=)Tj /Span<>> BDC ( )Tj EMC 0.798 0 Td [(3,3; )0.5(95% )0.5(\212\222 1,6\2266,5; )]TJ /T1_1 1 Tf 0 Tw 8.904 0 Td (\032)Tj /T1_0 1 Tf 0.065 Tw /Span<>> BDC ( )Tj EMC 0.776 0 Td (=)Tj /Span<>> BDC ( )Tj EMC 0.798 0 Td (0,001\), )Tj -0.016 Tw -19.37 -1.218 Td (\026)Tj /Span<>> BDC ( )Tj EMC (\r\036\030\024\016\021\027\024\f\021\034 \024\021\007\026\035\036\027\027\ \t\b \n\036\021\026\f\021\026\024\r \n\036\027\034\001\036 \027\026)Tj /Span<>> BDC ( )Tj EMC (20% )Tj 0 Tw 0 -1.218 TD (\(\210\234)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,2; 95% \212\222 0,1\2260,5; )Tj /T1_1 1 Tf (\032)Tj /T1_0 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,001\) [6].)Tj 0.264 Tw T* (\215\030\017\n\036\027\036\027\017\036 \f\021\026\027\007\026\030\021\027\ \024\005 \027\036\024\026\007\255\033\r\026\027\021\027\024\005 \216\214\ \230 \023\024)Tj 0 Tw (-)Tj 0.225 Tw T* [(\r\024\035\016\036\021 )0.5(\030\026\f\f\004\017\021\t\r\026\021\034 )0.5(\027\026)]TJ /Span<>> BDC ( )Tj EMC [(\023\024\035\027\t\005 )0.5(\024\021\r\036\021, \r)]TJ /Span<>> BDC ( )Tj EMC 18.475 0 Td (\f\030\036\007\027\036\n, )Tj 0.163 Tw -18.475 -1.218 Td (\r\f\036\020\024 \035\017\001\034 \031)Tj /Span<>> BDC ( )Tj EMC (\022\026\032\007\024\020\024 \007\036\f\016\021\024\020\024 \002\024\035\ \034\027\024\020\024 [18], \r)Tj /Span<>> BDC ( )Tj EMC (\021\024 )Tj 0.243 Tw T* (\r\030\036\n\016, \022\026\022 \023\030\017\n\036\027\036\027\017\036 \021\ \024\021\026\035\034\027\024\005 \027\036\024\026\007\255\033\r\026\027\021\ \027\024\005 )Tj 0.011 Tw T* [(\021\036\030\026\023\017\017 )0.5(\023\024\r\024\035\016\036\021 )0.6(\023\024\r\t\f\017\021\034 )0.5(\004\026\f\021\024\021\031 )0.5(\023\024\035\027\t\b )0.5(\024\021\r\036\021\024\r, )]TJ 0.257 Tw T* [(\004\021\024 )0.5(\021\026\022\032\036 \002\t\035\024 )0.5(\023\030\024\007\036\n\024\027\f\021\030\017\030\024\r\026\027\024 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC [(\027\026\001\036\n )0.5(\017\f)]TJ 0 Tw (-)Tj 0.089 Tw T* (\f\035\036\007\024\r\026\027\017\017. \210\021\n\036\004\036\027\026 \021\ \036\027\007\036\027\006\017\016 \022)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\034\001\036\005 \004\026\f\021\024\021\036 )Tj 0.24 Tw T* (\023\024\035\027\t\b \023\026\021\024\n\024\030\235\024\035\024\020\017\004\ \036\f\022\017\b \024\021\r\036\021\024\r, \022\024\021\024\030\026\016 \ \f\024)Tj 0 Tw (-)Tj 0.09 Tw T* (\f\021\026\r\017\035\026 20% \(9/45\) \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \230\203\230, \r)Tj /Span<>> BDC ( )Tj EMC (\f\030\026\r\027\036\027\017\017 \f)Tj /Span<>> BDC ( )Tj EMC (8% )Tj 0 Tw T* (\(5/66\) \()Tj /T1_1 1 Tf (\032)Tj /T1_0 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,05\).)Tj 0.359 Tw T* (\215\030\017\n\036\027\036\027\017\036 \230\203\230 \n\024\032\036\021 \031\ \r\036\035\017\004\017\021\034 \004\017\f\035\024 \023\026\006\017\036\027\ )Tj 0 Tw (-)Tj 0.353 Tw T* (\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC 2.962 0 Td [(\023\024\035\027\t\n )0.5(\022\035\017\027\017\004\036\f\022\017\n )0.5(\024\021\r\036\021\024\n \030\026\022\026 \023\030\016\n\024\005 )]TJ 0.425 Tw -2.962 -1.218 Td (\022\017\001\022\017 \007\035\016 \007\017\027\026\n\017\004\036\f\022\024\ \020\024 \027\026\002\035\033\007\036\027\017\016 \r)Tj /Span<>> BDC ( )Tj EMC (\030\026\n\022\026\b )Tj 0.371 Tw T* [(\f\021\030\026\021\036\020\017\017 \253w)-12(a)15(tch&w)-12(ai)-23.9(t\273. \205\031\027\007\026\n\036\027\021\026\035\034\027\t\n \017\f\f\035\ \036)]TJ 0 Tw (-)Tj 0.132 Tw T* (\007\024\r\026\027\017\036\n \r)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\n \027\026\023\030\026\r\035\036\027\017\017 \016\r\035\016\ \036\021\f\016 \023\031\002\035\017\022\026\006\017\016 )Tj 0.11 Tw T* (Habr-Gama)Tj /Span<>> BDC ( )Tj EMC (A. \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021., \022\024\021\024\030\t\036 \024\002\255\036\007\017\027\ \017\035\017 \030\036\031\035\034)Tj 0 Tw (-)Tj 0.336 Tw T* (\021\026\021\t \035\036\004\036\027\017\016 265 \002\024\035\034\027\t\b\ \030\026\022\024\n \023\030\016\n\024\005 \022\017\001\022\017. )Tj 0.023 Tw T* (\200)Tj /Span<>> BDC ( )Tj EMC (\007\026\027\027\024\n \017\f\f\035\036\007\024\r\026\027\017\017 \031\002\ \036\007\017\021\036\035\034\027\t\n \024\002\030\026\024\n \002\t\035\026\ )Tj 0.284 Tw T* [(\023\024\022\026\026\027\026 )0.5(\r\024\n\024\032\027\024\f\021\034 )0.5(\007\017\027\026\n\017\004\036\f\022\024\020\024 )0.6(\027\026\002\035\033\007\036\027\017\016 )]TJ 0.001 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\030\026\n\022\026\b \f\021\030\026\021\036\020\017\017 \253\027\026\002\ \035\033\007\036\027\017\016 \017)Tj /Span<>> BDC ( )Tj EMC (\r\t\032\017\007\026\027\017\016\273 \031)Tj /Span<>> BDC ( )Tj EMC (\023\026)Tj 0 Tw (-)Tj 0.324 Tw T* (\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\023\024\035\027\t\n \022\035\017\027\017\004\036\f\022\017\n \024\021\r\ \036\021\024\n \024\023\031\b\024\035\017. )Tj 0.05 Tw T* (\215\024)Tj /Span<>> BDC ( )Tj EMC (\007\024\f\021\017\032\036\027\017\017 10 \035\036\021 \027\026\002\035\033\ \007\036\027\017\016 \023\024\035\027\t\005 \022\035\017\027\017\004\036\ )Tj 0 Tw (-)Tj 0.156 Tw T* [(\f\022\017\005 )0.5(\024\021\r\036\021 )0.6(\023\024\007\021\r\036\030\032\007\036\027 )0.6(\031)]TJ /Span<>> BDC ( )Tj EMC 11.584 0 Td [(27% )0.5(\023\026\006\017\036\027\021\024\r )0.6(\023\030\017)]TJ /Span<>> BDC ( )Tj EMC 8.767 0 Td (97% )Tj 0.296 Tw -20.351 -1.218 Td [(\024\002\013\036\005 )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC 4.243 0 Td [(84% )0.5(\002\036\030\036\006\017\007\017\r\027\024\005 )0.5(\r\t\032\017\r\026\036\n\024\f\021\017 )0.6([19]. )]TJ -0.028 Tw -4.243 -1.218 Td (\215\030\017)Tj /Span<>> BDC ( )Tj EMC (\026\027\026\035\017\036 \004\026\f\021\024\021\t \023\024\035\027\t\b \ \022\035\017\027\017\004\036\f\022\017\b \024\021\r\036\021\024\r \n\t )Tj 0.147 Tw T* (\f\021\024\035\022\027\031\035\017\f\034 \f)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\002\035\036\n\024\005 \024\021\f\031\021\f\021\r\017\016 \036\ \007\017\027\t\b \022\030\017\021\036)Tj 0 Tw (-)Tj 0.001 Tw T* (\030\017\036\r \017)Tj /Span<>> BDC ( )Tj EMC (\n\036\021\024\007\024\r \024\006\036\027\022\017. \210\002\013\036\023\030\ \017\027\016\021\t\n \023\030\026\r\017\035\024\n \016\r)Tj 0 Tw (-)Tj 0.096 Tw T* (\035\016\036\021\f\016 \n\017\027\017\n\026\035\034\027\t\005 \007\r\031\ \b\035\036\021\027\017\005 \023\024\030\024\020 \027\026\002\035\033\007\ \036\027\017\016, )Tj 0.118 Tw T* (\023\024)Tj /Span<>> BDC ( )Tj EMC [(\007\024\f\021\017\032\036\027\017\017 )0.5(\022\024\021\024\030\024\020\024 )0.5(\n\024\032\027\024 \020\024\r\024\030\017\021\034 )0.5(\024)]TJ /Span<>> BDC ( )Tj EMC (\f\021\024\005\022\024\n )Tj 0.079 Tw T* (\022\035\017\027\017\004\036\f\022\024\n \024\021\r\036\021\036. \212\026\ \027\027\t\005 \r\t\r\024\007 \f\007\036\035\026\027, \024\f\027\024\r\t\ )Tj 0 Tw (-)Tj -0.02 Tw T* (\r\026\016\f\034 \027\026)Tj /Span<>> BDC ( )Tj EMC (\030\036\031\035\034\021\026\021\026\b \n\036\032\007\031\027\026\030\024\ \007\027\024\005 \002\026\t \007\026\027\027\t\b)Tj /Span<>> BDC ( )Tj EMC (\227 )Tj 0.083 Tw T* [(\253Inter)-15(na)15.1(t)-32(ional W)12(a)15(tch&W)12(ai)-24(t Da)14.9(t)15.1(abase\273, \023\024)]TJ /Span<>> BDC ( )Tj EMC (\007\026\027\027\t\n \022\024)Tj 0 Tw (-)Tj 0.025 Tw T* [(\021\024\030\024\005 \030\036\006\017\007\017\r\t \030\026\022\026 \023\030\ \016\n\024\005 )0.5(\022\017\001\022\017 \r\024\027\017\022\026\033\021 )0.5(\004\026\013\036 )]TJ 0.021 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\r\t\036 \007\r\026 \020\024\007\026 [20]. \200)Tj /Span<>> BDC ( )Tj EMC (\027\026\001\036\n \017\f\f\035\036\007\024\r\026\027\017\017, \r)Tj /Span<>> BDC ( )Tj EMC (\027\026)Tj 0 Tw (-)Tj -0.019 Tw T* [(\f\021\024\016\013\017\005 \n\024\n\036\027\021, \023\024\007\026\r\035\016\ \033\013\036\036 )0.5(\002\024\035\034\001\017\027\f\021\r\024 \002\024\035\034\027\t\b )]TJ 0.282 Tw T* (\036\013\036 \027\036 \007\024\f\021\017\020\035\017 \007\r\031\b\035\036\ \021\027\036\020\024 \023\024\030\024\020\026 \027\026\002\035\033\007\036\ \027\017\016. )Tj 0.53 Tw T* (\210\007\027\026\022\024 \023\024\035\031\004\036\027\027\t\036 \023\030\ \036\007\r\026\030\017\021\036\035\034\027\t\036 \030\036\031\035\034\021\ \026\021\t )Tj 0.052 Tw T* (\r\t\020\035\016\007\016\021 \024\023\021\017\n\017\f\021\017\004\027\024\ . \211)Tj /Span<>> BDC ( )Tj EMC (17)Tj /Span<>> BDC ( )Tj EMC (\(32%\) \017)Tj /Span<>> BDC ( )Tj EMC (53 \023\026\006\017\036\027\021\024\r )Tj -0.003 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \230\203\230 \017)Tj /Span<>> BDC ( )Tj EMC (\031)Tj /Span<>> BDC ( )Tj EMC (6)Tj /Span<>> BDC ( )Tj EMC (\(9%\) \017)Tj /Span<>> BDC ( )Tj EMC (68)Tj /Span<>> BDC ( )Tj EMC (\227 \r)Tj /Span<>> BDC ( )Tj EMC [(\020\030\031\023\023\036 \216\214\230 )0.5(\023\030\017)]TJ /Span<>> BDC ( )Tj EMC 20.72 0 Td (\n\036)Tj 0 Tw (-)Tj 0.092 Tw -20.72 -1.218 Td (\007\017\026\027\036 \027\026\002\035\033\007\036\027\017\016 15 \(11, 1\ 7\) \n\036\f\016\006\036\r \f\024\b\030\026\027\016\033\021\f\016 )Tj 0.03 Tw T* (\023\030\017\027\026\022\017 \023\024\035\027\024\020\024 \022\035\017\027\ \017\004\036\f\022\024\020\024 \024\021\r\036\021\026, \004\021\024 \016\ \r\035\016\036\021\f\016 )Tj -0.05 Tw T* [(\f\021\026\021\017\f\021\017\004\036\f\022\017 )0.6(\027\026\004\017\n\t\n )0.5(\()]TJ /T1_1 1 Tf 0 Tw (\032)Tj /T1_0 1 Tf -0.05 Tw /Span<>> BDC ( )Tj EMC 11.408 0 Td (=)Tj /Span<>> BDC ( )Tj EMC 0.682 0 Td [(0,001\). )0.5(\204\036\007\017\026\027\026 )0.6(\(Q1, )0.5(Q3\) )]TJ 0.07 Tw -12.091 -1.218 Td (\r\030\036\n\036\027\017 \027\026\002\035\033\007\036\027\017\016 15,3 \(\ 11,1; 17,4\) \n\036\f\016\006\036\r \024\020\030\026)Tj 0 Tw (-)Tj T* (\027\017\004\017\r\026\036\021 \007\024\f\021\024\r\036\030\027\024\f\021\ \034 \023\024\035\031\004\036\027\027\t\b \030\036\031\035\034\021\026\021\ \024\r.)Tj 0.219 Tw T* [(\203\036\007\024\f\021\026\021\022\024\n \007\026\027\027\024\020\024 \017\ \f\f\035\036\007\024\r\026\027\017\016 )0.5(\016\r\035\016\036\021\f\016 \002\024\035\034)]TJ 0 Tw (-)Tj 0.664 Tw T* (\001\024\036 \022\024\035\017\004\036\f\021\r\024 \r\t\002\t\r\001\017\b\ \017-\023\024\007 \027\026\002\035\033\007\036\027\017\016 )Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0 Tw 7.5 0 0 7.5 70.8661 759.8869 Tm [(\021\032)50(\b)42(\032\231\027 \213\036)30.1(\005\t\033)30(\b)]TJ 52.896 0 Td (LEADING ARTICLE)Tj -52.896 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 23, \023\0221)69(, 202)69(4)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 23, \023\0221)69(, 202)69(4)]TJ /T1_4 1 Tf 25 0 0 25 27.2901 56.0378 Tm (18)Tj ET endstream endobj 2487 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\235\225\225\016\n)-10(\026\220\r\001\025\006)-10(\026\216 \026)11(\025\026)11(\013\007\216\001\025\203 \001\016\025\013\201\230\212\r\013\001\026\001\025\ \203 \026)11(\016\002\013\221\220\220 \r\022\007\016\017\016\001\220\220 \002\013\n\013\ )]TJ 0 -1 TD [(\221\002\205\024\025\203 \n\220\n\220. \033\016\222)21(\215\007\216)21.1(\026)10.9(\013\026\020 \002\013\001\201\025\024\220\222\220\002\025\r\013\001\001\025\ \202)10(\025 \220\006\006)-9.9(\007\016\201\025\r\013\001\220\205)]TJ 39.131 1 Td [(Ef)-31(fectiv)12(eness of th)11(e total neoadju)10.1(v)10(ant th)11(er)21.1(apy in r)31(ectal )]TJ 2.292 -1 Td [(cancer tr)31(eatment. Results of th)11(e r)21(andomiz)10(ed trial)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0.366 Tw 10 0 0 10 42.5197 213.3539 Tm (\200)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\006\036\f\f\036 \007\017\027\026\n\017\004\036\f\022\024\020\ \024 \027\026\002\035\033\007\036\027\017\016 \r)Tj /Span<>> BDC ( )Tj EMC (\030\026\n\022\026\b )Tj 0.536 Tw 0 -1.218 TD [(\f\021\030\026\021\036\020\017\017 )0.6(\253w)-12(a)15(tch&w)-12(ai)-24(t\273 )0.5(\024\023\036\030\026\021\017\r\027\024\036 )0.5(\r\n\036\001\026\021\036\035\034)]TJ 0 Tw (-)Tj 0.131 Tw T* (\f\021\r\024 \002\t\035\024 \r\t\023\024\035\027\036\027\024 \036\013\036\ \031)Tj /Span<>> BDC ( )Tj EMC (4 \023\026\006\017\036\027\021\024\r \017)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\t )Tj 0.096 Tw T* (\230\203\230 \017)Tj /Span<>> BDC ( )Tj EMC (\031 3 \023\026\006\017\036\027\021\024\r \017)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\t \216\214\230. \230\026\022\017\n \024\002\030\026\ \024\n, )Tj 0.155 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \230\203\230 \024\023\036\030\026\021\017\r\027\ \024\036 \r\n\036\001\026\021\036\035\034\f\021\r\024 \r\t\023\024\035\027\ \036)Tj 0 Tw (-)Tj 0.035 Tw T* (\027\024 \031)Tj /Span<>> BDC ( )Tj EMC (45)Tj /Span<>> BDC ( )Tj EMC (\(75%\) \017)Tj /Span<>> BDC ( )Tj EMC (60 \023\026\006\017\036\027\021\024\r \017)Tj /Span<>> BDC ( )Tj EMC (\031 66)Tj /Span<>> BDC ( )Tj EMC (\(93%\) \017)Tj /Span<>> BDC ( )Tj EMC (71)Tj /Span<>> BDC ( )Tj EMC (\227 )Tj 0.056 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \216\214\230. \206\030\031\023\023\t \002\t\035\ \017 \f\024\023\024\f\021\026\r\017\n\t \023\024)Tj /Span<>> BDC ( )Tj EMC (\n\036\007\017\026\027\036 )Tj 0.678 Tw T* (\023\030\024\007\024\035\032\017\021\036\035\034\027\024\f\021\017 \024\023\ \036\030\026\021\017\r\027\024\020\024 \r\n\036\001\026\021\036\035\034\f\ \021\r\026, )Tj 0.128 Tw T* (\017\027\021\030\026\024\023\036\030\026\006\017\024\027\027\024\005 \022\ \030\024\r\024\023\024\021\036\030\036 \017)Tj /Span<>> BDC ( )Tj EMC (\r\017\007\031 \b\017\030\031\030\020\017\004\036)Tj 0 Tw (-)Tj T* (\f\022\024\020\024 \007\024\f\021\031\023\026 \(\230\026\002\035. 3\).)Tj 0.756 Tw T* (\211 \024\007\027\024\020\024 \023\026\006\017\036\027\021\026 \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \230\203\230 \023\024\f\035\036\024\023\036)Tj 0 Tw (-)Tj 1.493 Tw T* (\030\026\006\017\024\027\027\t\005 \023\036\030\017\024\007 \024\f\035\024\ \032\027\017\035\f\016 \030\026\r\017\021\017\036\n )Tj 0.639 Tw 23.244 13.396 Td [(\021\030\024\n\002\024\220\n\002\024\035\017\017 )0.5(\035\036\020\024\004\027\024\005 \026\030\021\036\030\017\017, \004\021\024\ )0.5(\023\030\017\r\036\035\024 )]TJ -0.011 Tw T* (\022)Tj /Span<>> BDC ( )Tj EMC 0.682 0 Td [(\f\n\036\030\021\017 )0.5(\002\024\035\034\027\024\020\024. )0.6(\214\036\021\026\035\034\027\024\f\021\034 )0.6(\f\024\f\021\026\r\017\035\026 )0.5(2% )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 19.258 0 Td (\020\030\031\023)Tj 0 Tw (-)Tj 0.202 Tw -19.94 -1.218 Td [(\023\036 \230\203\230. \215\024\f\035\036\024\023\036\030\026\006\017\024\ \027\027\t\036 \024\f\035\024\032\027\036\027\017\016 )0.5(\024\021\n\036\004\036\027\t )]TJ 0.001 Tw T* (\031)Tj /Span<>> BDC ( )Tj EMC (33% \023\026\006\017\036\027\021\024\r)Tj /Span<>> BDC ( )Tj EMC (\227 \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \230\203\230 \017)Tj /Span<>> BDC ( )Tj EMC (\031 27%)Tj /Span<>> BDC ( )Tj EMC (\227 \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 )Tj 0.026 Tw T* (\216\214\230 \()Tj /T1_2 1 Tf 0 Tw (\032)Tj /T1_1 1 Tf 0.026 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,6\). \230\030\036\021\034\033 \f\021\036\023\036\027\034 \023\024)Tj /Span<>> BDC ( )Tj EMC [(\001\022\026\035\036 Cl)-16(av)-16(ien-Dind)-15.9(o )]TJ 0.147 Tw T* (\027\026\002\035\033\007\026\035\017 \031)Tj /Span<>> BDC ( )Tj EMC (\021\030\036\b \023\026\006\017\036\027\021\024\r \017)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\t \230\203\230, \r)Tj /Span<>> BDC ( )Tj EMC (\007\r\031\b )Tj 0.244 Tw T* (\f\035\031\004\026\016\b \023\030\017\004\017\027\024\005 \023\024\r\021\ \024\030\027\024\020\024 \r\n\036\001\026\021\036\035\034\f\021\r\026 \002\ \t\035\026 )Tj 0.107 Tw T* (\023\036\030\235\024\030\026\006\017\016 \f\021\036\027\022\017 \021\024\ \027\022\024\005 \022\017\001\022\017, \r)Tj /Span<>> BDC ( )Tj EMC (\007\030\031\020\024\n)Tj /Span<>> BDC ( )Tj EMC (\227 \022\030\024)Tj 0 Tw (-)Tj 0.063 Tw T* (\r\024\021\036\004\036\027\017\036. \203\036\f\024\f\021\024\016\021\036\ \035\034\027\024\f\021\034 \026\027\026\f\021\024\n\024\026 \200)Tj /Span<>> BDC ( )Tj EMC (\f\021\036\023\036\027\017 )Tj 0.01 Tw T* (\r\t\016\r\035\036\027\026 \031)Tj /Span<>> BDC ( )Tj EMC (\007\r\031\b \023\026\006\017\036\027\021\024\r \(9%\) \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \230\203\230 \017)Tj /Span<>> BDC ( )Tj EMC (\031 \024\007)Tj 0 Tw (-)Tj 0.106 Tw T* (\027\024\020\024 \(3%\) \023\026\006\017\036\027\021\026 \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \230\203\230. \204\036\007\017\026\027\026 \(Q1\ , Q3\) )Tj -0.032 Tw T* (\023\024\f\035\036\024\023\036\030\026\006\017\024\027\027\024\020\024 \007\ \027\016 \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \230\203\230 \f\024\f\021\026\r\017\035\026 9 \(\ 6, )Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0 Tw 9 0 0 9 42.5197 730.483 Tm (\020\004\206\f\t\204\004 4.)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf ( \224\026\t\024\n\024\026 \025)Tj /Span<>> BDC ( )Tj EMC (\t\024\032\205\013\024\205\032\026 \033\n\t\023\031\n\033\031\032\026\203\ \025\n\021\021\020\004 \n\t\023\n\204\021\031\021\025\017)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0 -1.2 TD [(T)48(able 4.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf [( R)20.1(ate and structure of postoperativ)13.2(e com)16.1(plications)]TJ ET 0 0 0 1 K 0.5 w /GS2 gs q 1 0 0 1 42.5197 715.181 cm 0 0 m 167.494 0 l S Q q 1 0 0 1 42.7697 694.3618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 210.0138 715.181 cm 0 0 m 79.37 0 l S Q q 1 0 0 1 210.0138 694.3618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 289.3839 715.181 cm 0 0 m 79.37 0 l S Q q 1 0 0 1 289.3839 694.3618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 368.7539 715.181 cm 0 0 m 79.37 0 l S Q q 1 0 0 1 368.7539 694.3618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 448.124 715.181 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 448.124 694.3618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 496.313 694.3618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 42.5197 694.1118 cm 0 0 m 167.494 0 l S Q q 1 0 0 1 42.7697 682.9005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 210.0138 694.1118 cm 0 0 m 79.37 0 l S Q q 1 0 0 1 210.0138 682.9005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 289.3839 694.1118 cm 0 0 m 79.37 0 l S Q q 1 0 0 1 289.3839 682.9005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 368.7539 694.1118 cm 0 0 m 79.37 0 l S Q q 1 0 0 1 368.7539 682.9005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 448.124 694.1118 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 448.124 682.9005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 682.9005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 682.6505 cm 0 0 m 167.494 0 l S Q q 1 0 0 1 42.7697 671.4393 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 210.0138 682.6505 cm 0 0 m 79.37 0 l S Q q 1 0 0 1 210.0138 671.4393 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 289.3839 682.6505 cm 0 0 m 79.37 0 l S Q q 1 0 0 1 289.3839 671.4393 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 368.7539 682.6505 cm 0 0 m 79.37 0 l S Q q 1 0 0 1 368.7539 671.4393 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 448.124 682.6505 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 448.124 671.4393 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 671.4393 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 671.1893 cm 0 0 m 167.494 0 l S Q q 1 0 0 1 42.7697 659.978 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 210.0138 671.1893 cm 0 0 m 79.37 0 l S Q q 1 0 0 1 210.0138 659.978 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 289.3839 671.1893 cm 0 0 m 79.37 0 l S Q q 1 0 0 1 289.3839 659.978 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 368.7539 671.1893 cm 0 0 m 79.37 0 l S Q q 1 0 0 1 368.7539 659.978 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 448.124 671.1893 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 448.124 659.978 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 659.978 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 659.728 cm 0 0 m 167.494 0 l S Q q 1 0 0 1 42.7697 638.9167 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 210.0138 659.728 cm 0 0 m 79.37 0 l S Q q 1 0 0 1 210.0138 638.9167 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 289.3839 659.728 cm 0 0 m 79.37 0 l S Q q 1 0 0 1 289.3839 638.9167 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 368.7539 659.728 cm 0 0 m 79.37 0 l S Q q 1 0 0 1 368.7539 638.9167 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 448.124 659.728 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 448.124 638.9167 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 496.313 638.9167 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 42.5197 638.6667 cm 0 0 m 167.494 0 l S Q q 1 0 0 1 42.7697 627.4554 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 210.0138 638.6667 cm 0 0 m 79.37 0 l S Q q 1 0 0 1 210.0138 627.4554 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 289.3839 638.6667 cm 0 0 m 79.37 0 l S Q q 1 0 0 1 289.3839 627.4554 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 368.7539 638.6667 cm 0 0 m 79.37 0 l S Q q 1 0 0 1 368.7539 627.4554 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 448.124 638.6667 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 448.124 627.4554 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 627.4554 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 627.2054 cm 0 0 m 167.494 0 l S Q q 1 0 0 1 42.7697 615.9941 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 210.0138 627.2054 cm 0 0 m 79.37 0 l S Q q 1 0 0 1 210.0138 615.9941 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 289.3839 627.2054 cm 0 0 m 79.37 0 l S Q q 1 0 0 1 289.3839 615.9941 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 368.7539 627.2054 cm 0 0 m 79.37 0 l S Q q 1 0 0 1 368.7539 615.9941 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 448.124 627.2054 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 448.124 615.9941 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 615.9941 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 615.7441 cm 0 0 m 167.494 0 l S Q q 1 0 0 1 42.7697 604.5328 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 210.0138 615.7441 cm 0 0 m 79.37 0 l S Q q 1 0 0 1 210.0138 604.5328 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 289.3839 615.7441 cm 0 0 m 79.37 0 l S Q q 1 0 0 1 289.3839 604.5328 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 368.7539 615.7441 cm 0 0 m 79.37 0 l S Q q 1 0 0 1 368.7539 604.5328 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 448.124 615.7441 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 448.124 604.5328 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 604.5328 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 604.2828 cm 0 0 m 167.494 0 l S Q q 1 0 0 1 42.7697 593.0715 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 210.0138 604.2828 cm 0 0 m 79.37 0 l S Q q 1 0 0 1 210.0138 593.0715 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 289.3839 604.2828 cm 0 0 m 79.37 0 l S Q q 1 0 0 1 289.3839 593.0715 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 368.7539 604.2828 cm 0 0 m 79.37 0 l S Q q 1 0 0 1 368.7539 593.0715 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 448.124 604.2828 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 448.124 593.0715 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 593.0715 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 592.8215 cm 0 0 m 167.494 0 l S Q q 1 0 0 1 210.0138 592.8215 cm 0 0 m 79.37 0 l S Q q 1 0 0 1 289.3839 592.8215 cm 0 0 m 79.37 0 l S Q q 1 0 0 1 368.7539 592.8215 cm 0 0 m 79.37 0 l S Q q 1 0 0 1 448.124 592.8215 cm 0 0 m 48.439 0 l S Q BT /GS1 gs /T1_3 1 Tf 8 0 0 8 108.192 701.7465 Tm (\200\032\022\032\215\036\020\022)Tj 14.071 0.6 Td (\255\003\r\212\r\b\001 \003\235\202\r\217\003\t )Tj 0.214 -1.2 Td (\(Clavien-Dindo\))Tj 10.944 1.2 Td (\027\006\210\212\212\004 \020\025\020)Tj 0.993 -1.2 Td (N)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (45)Tj 8.917 1.2 Td (\027\006\210\212\212\004 \221\035\020)Tj 1.004 -1.2 Td (N)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (66)Tj /T1_4 1 Tf 9.098 0.6 Td (P)Tj /T1_1 1 Tf -53.064 -2.033 Td (\217\026\027\036\r\026\016 \017\027\235\036\022\006\017\016, )Tj /T1_2 1 Tf (n)Tj /T1_1 1 Tf ( \(%\))Tj 25.325 0 Td (I)Tj 8.742 0 Td (1)Tj /Span<>> BDC ( )Tj EMC (\(2%\))Tj 9.921 0 Td (1)Tj /Span<>> BDC ( )Tj EMC (\(2%\))Tj 8.746 0 Td (0,9)Tj -52.734 -1.433 Td (\202\021\024\027\017\016 \n\024\004\036\r\024\020\024 \023\031\t\030\016\ , )Tj /T1_2 1 Tf (n)Tj /T1_1 1 Tf ( \(%\))Tj 25.325 0 Td (I)Tj 8.742 0 Td (3)Tj /Span<>> BDC ( )Tj EMC (\(7%\))Tj 9.921 0 Td (6)Tj /Span<>> BDC ( )Tj EMC (\(9%\))Tj 8.746 0 Td (0,5)Tj -52.734 -1.433 Td (\215\026\030\036 \240\025\230, )Tj /T1_2 1 Tf (n)Tj /T1_1 1 Tf ( \(%\))Tj 25.138 0 Td (II)Tj 8.679 0 Td (5)Tj /Span<>> BDC ( )Tj EMC (\(11%\))Tj 9.921 0 Td (9)Tj /Span<>> BDC ( )Tj EMC (\(14%\))Tj 8.996 0 Td (0,8)Tj -52.734 -1.433 Td (\203\036\f\024\f\021\024\016\021\036\035\034\027\024\f\021\034 \026\027\026\ \f\021\024\n\024\026, )Tj /T1_2 1 Tf (n)Tj /T1_1 1 Tf ( \(%\))Tj T* (B \f\021\036\023\036\027\034)Tj 25.138 1.2 Td (II)Tj 8.208 0 Td (2/23)Tj /Span<>> BDC ( )Tj EMC (\(9%\))Tj 9.921 0 Td (1/30)Tj /Span<>> BDC ( )Tj EMC (\(3%\))Tj 9.467 0 Td (0,7)Tj -52.734 -2.633 Td (\215\036\030\235\024\030\026\006\017\016 \021\024\027\022\024\005 \022\017\ \001\022\017, )Tj /T1_2 1 Tf (n)Tj /T1_1 1 Tf ( \(%\))Tj 24.678 0 Td (IIIB)Tj 9.389 0 Td (2)Tj /Span<>> BDC ( )Tj EMC (\(4%\))Tj 11.037 0 Td (0)Tj 7.013 0 Td (>)Tj /Span<>> BDC ( )Tj EMC (0,99)Tj -52.118 -1.433 Td (\025\030\024\r\024\021\036\004\036\027\017\036, )Tj /T1_2 1 Tf (n)Tj /T1_1 1 Tf ( \(%\))Tj 24.678 0 Td (IIIB)Tj 9.389 0 Td (1)Tj /Span<>> BDC ( )Tj EMC (\(2%\))Tj 11.037 0 Td (0)Tj 7.013 0 Td (>)Tj /Span<>> BDC ( )Tj EMC (0,99)Tj -52.118 -1.433 Td (\230\224\214\202, )Tj /T1_2 1 Tf (n)Tj /T1_1 1 Tf ( \(%\))Tj 25.262 0 Td (V)Tj 8.805 0 Td (1)Tj /Span<>> BDC ( )Tj EMC (\(2%\))Tj 11.037 0 Td (0)Tj 7.013 0 Td (>)Tj /Span<>> BDC ( )Tj EMC (0,99)Tj -52.118 -1.433 Td (\200\f\036\020\024, )Tj /T1_2 1 Tf (n)Tj /T1_1 1 Tf ( \(%\))Tj 33.567 0 Td (15)Tj /Span<>> BDC ( )Tj EMC (\(33%\))Tj 9.921 0 Td (17)Tj /Span<>> BDC ( )Tj EMC (\(26%\))Tj 9.246 0 Td (0,6)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 9 0 0 9 42.5197 576.1023 Tm (\020\004\206\f\t\204\004 5.)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf [( \212\031\016\205\023\022\024\026\024\020 \033\026\024\n\003\n\032\f\n\023\ \n\202\025\006\031\t\013\n\202\n \025\t\t\023\031\030\n\027\026\021\025\002\ \n\033\031\032\026\203\025\n\021)0.5(\021\020\004 \033\032\031\033\026\032\026\024\n\027)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0 -1.2 TD [(T)48(able 5.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf [( The results of a pathomor)-17.7(phological study of remov)13.2(ed specimens)]TJ ET /GS2 gs q 1 0 0 1 42.5197 560.8003 cm 0 0 m 227.022 0 l S Q q 1 0 0 1 42.7697 539.9811 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 269.5414 560.8003 cm 0 0 m 85.039 0 l S Q q 1 0 0 1 269.5414 539.9811 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 354.5807 560.8003 cm 0 0 m 85.039 0 l S Q q 1 0 0 1 354.5807 539.9811 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 439.6201 560.8003 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 439.6201 539.9811 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 496.313 539.9811 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 42.5197 539.7311 cm 0 0 m 227.022 0 l S Q q 1 0 0 1 42.7697 480.5198 cm 0 0 m 0 58.961 l S Q q 1 0 0 1 269.5414 539.7311 cm 0 0 m 85.039 0 l S Q q 1 0 0 1 269.5414 480.5198 cm 0 0 m 0 58.961 l S Q q 1 0 0 1 354.5807 539.7311 cm 0 0 m 85.039 0 l S Q q 1 0 0 1 354.5807 480.5198 cm 0 0 m 0 58.961 l S Q q 1 0 0 1 439.6201 539.7311 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 439.6201 480.5198 cm 0 0 m 0 58.961 l S Q q 1 0 0 1 496.313 480.5198 cm 0 0 m 0 58.961 l S Q q 1 0 0 1 42.5197 480.2698 cm 0 0 m 227.022 0 l S Q q 1 0 0 1 42.7697 440.2585 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 269.5414 480.2698 cm 0 0 m 85.039 0 l S Q q 1 0 0 1 269.5414 440.2585 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 354.5807 480.2698 cm 0 0 m 85.039 0 l S Q q 1 0 0 1 354.5807 440.2585 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 439.6201 480.2698 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 439.6201 440.2585 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 496.313 440.2585 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 42.5197 440.0085 cm 0 0 m 227.022 0 l S Q q 1 0 0 1 42.7697 428.7972 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 269.5414 440.0085 cm 0 0 m 85.039 0 l S Q q 1 0 0 1 269.5414 428.7972 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 354.5807 440.0085 cm 0 0 m 85.039 0 l S Q q 1 0 0 1 354.5807 428.7972 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 439.6201 440.0085 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 439.6201 428.7972 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 428.7972 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 428.5472 cm 0 0 m 227.022 0 l S Q q 1 0 0 1 42.7697 417.328 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 269.5414 428.5472 cm 0 0 m 85.039 0 l S Q q 1 0 0 1 269.5414 417.328 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 354.5807 428.5472 cm 0 0 m 85.039 0 l S Q q 1 0 0 1 354.5807 417.328 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 439.6201 428.5472 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 439.6201 417.328 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 496.313 417.328 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 42.5197 417.078 cm 0 0 m 227.022 0 l S Q q 1 0 0 1 42.7697 357.8667 cm 0 0 m 0 58.961 l S Q q 1 0 0 1 269.5414 417.078 cm 0 0 m 85.039 0 l S Q q 1 0 0 1 269.5414 357.8667 cm 0 0 m 0 58.961 l S Q q 1 0 0 1 354.5807 417.078 cm 0 0 m 85.039 0 l S Q q 1 0 0 1 354.5807 357.8667 cm 0 0 m 0 58.961 l S Q q 1 0 0 1 439.6201 417.078 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 439.6201 357.8667 cm 0 0 m 0 58.961 l S Q q 1 0 0 1 496.313 357.8667 cm 0 0 m 0 58.961 l S Q q 1 0 0 1 42.5197 357.6167 cm 0 0 m 227.022 0 l S Q q 1 0 0 1 42.7697 346.4055 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 269.5414 357.6167 cm 0 0 m 85.039 0 l S Q q 1 0 0 1 269.5414 346.4055 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 354.5807 357.6167 cm 0 0 m 85.039 0 l S Q q 1 0 0 1 354.5807 346.4055 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 439.6201 357.6167 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 439.6201 346.4055 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 346.4055 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 346.1555 cm 0 0 m 227.022 0 l S Q q 1 0 0 1 42.7697 315.7441 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 269.5414 346.1555 cm 0 0 m 85.039 0 l S Q q 1 0 0 1 269.5414 315.7441 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 354.5807 346.1555 cm 0 0 m 85.039 0 l S Q q 1 0 0 1 354.5807 315.7441 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 439.6201 346.1555 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 439.6201 315.7441 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 496.313 315.7441 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 42.5197 315.4941 cm 0 0 m 227.022 0 l S Q q 1 0 0 1 269.5414 315.4941 cm 0 0 m 85.039 0 l S Q q 1 0 0 1 354.5807 315.4941 cm 0 0 m 85.039 0 l S Q q 1 0 0 1 439.6201 315.4941 cm 0 0 m 56.943 0 l S Q BT /GS1 gs /T1_3 1 Tf 8 0 0 8 137.9558 547.3657 Tm (\200\032\022\032\215\036\020\022)Tj 19.382 0.6 Td (\027\006\210\212\212\004 \020\025\020)Tj 0.993 -1.2 Td (N)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (45)Tj 9.625 1.2 Td (\027\006\210\212\212\004 \221\035\020)Tj 1.004 -1.2 Td (N)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (66)Tj /T1_4 1 Tf 9.984 0.6 Td (P)Tj /T1_1 1 Tf -52.533 -2.033 Td (ypT \f\021\026\007\017\016, )Tj /T1_2 1 Tf (n)Tj /T1_1 1 Tf ( \(%\))Tj 0 -1.2 TD (ypT0)Tj T* (ypT1)Tj T* (ypT2)Tj T* (ypT3)Tj T* (ypT4)Tj 31.441 4.8 Td (11)Tj /Span<>> BDC ( )Tj EMC (\(24%\))Tj 0.5 -1.2 Td (3)Tj /Span<>> BDC ( )Tj EMC (\(7%\))Tj -0.25 -1.2 Td (8)Tj /Span<>> BDC ( )Tj EMC (\(18%\))Tj -0.25 -1.2 Td (22)Tj /Span<>> BDC ( )Tj EMC (\(49%\))Tj 0.5 -1.2 Td (1)Tj /Span<>> BDC ( )Tj EMC (\(2%\))Tj 10.63 4.8 Td (5)Tj /Span<>> BDC ( )Tj EMC (\(8%\))Tj T* (3)Tj /Span<>> BDC ( )Tj EMC (\(5%\))Tj -0.5 -1.2 Td (18)Tj /Span<>> BDC ( )Tj EMC (\(27%\))Tj T* (37)Tj /Span<>> BDC ( )Tj EMC (\(55%\))Tj 0.5 -1.2 Td (3)Tj /Span<>> BDC ( )Tj EMC (\(5%\))Tj 9.632 6 Td (0,2)Tj -52.203 -7.433 Td (ypN \f\021\026\007\017\016, )Tj /T1_2 1 Tf (n)Tj /T1_1 1 Tf ( \(%\))Tj T* (ypN0)Tj T* (ypN1)Tj T* (ypN2)Tj 31.441 2.4 Td (33)Tj /Span<>> BDC ( )Tj EMC (\(73%\))Tj 0.25 -1.2 Td (7)Tj /Span<>> BDC ( )Tj EMC (\(16%\))Tj T* (5)Tj /Span<>> BDC ( )Tj EMC (\(11%\))Tj 10.38 2.4 Td (42)Tj /Span<>> BDC ( )Tj EMC (\(64%\))Tj T* (14)Tj /Span<>> BDC ( )Tj EMC (\(21%\))Tj T* (10)Tj /Span<>> BDC ( )Tj EMC (\(15%\))Tj 10.132 3.6 Td (0,5)Tj -52.203 -5.033 Td (\215\036\030\017\027\036\r\030\026\035\034\027\026\016 \017\027\r\026\017\ \016 \(PN\), )Tj /T1_2 1 Tf (n)Tj /T1_1 1 Tf ( \(%\))Tj 31.691 0 Td (6)Tj /Span<>> BDC ( )Tj EMC (\(14%\))Tj 10.38 0 Td (16)Tj /Span<>> BDC ( )Tj EMC (\(24%\))Tj 10.132 0 Td (0,2)Tj -52.203 -1.433 Td (\214\017\n\235\024\r\026\f\022\031\035\016\030\027\026\016 \017\027\r\026\ \017\016 \(LV\), )Tj /T1_2 1 Tf (n)Tj /T1_1 1 Tf ( \(%\))Tj 31.441 0 Td (18)Tj /Span<>> BDC ( )Tj EMC (\(40%\))Tj 10.63 0 Td (39)Tj /Span<>> BDC ( )Tj EMC (\(59%\))Tj /T1_3 1 Tf 9.742 -0.001 Td (0,02)Tj /T1_1 1 Tf -51.813 -1.433 Td (TRG \023\024)Tj /Span<>> BDC ( )Tj EMC (Rayn, )Tj /T1_2 1 Tf (n)Tj /T1_1 1 Tf ( \(%\))Tj T* (TRG0)Tj T* (TRG1)Tj 0 -1.2 TD (TRG2)Tj 0 -1.2 TD (TRG3)Tj 0 -1.2 TD (TRG4)Tj 31.691 4.8 Td (9)Tj /Span<>> BDC ( )Tj EMC (\(20%\))Tj T* (9)Tj /Span<>> BDC ( )Tj EMC (\(20%\))Tj -0.25 -1.2 Td (18)Tj /Span<>> BDC ( )Tj EMC (\(40%\))Tj 0.25 -1.2 Td (9)Tj /Span<>> BDC ( )Tj EMC (\(20%\))Tj 0.25 -1.2 Td (0)Tj /Span<>> BDC ( )Tj EMC (\(0%\))Tj 10.63 4.8 Td (5)Tj /Span<>> BDC ( )Tj EMC (\(7%\))Tj -0.5 -1.2 Td (12)Tj /Span<>> BDC ( )Tj EMC (\(18%\))Tj 0 -1.2 TD (40)Tj /Span<>> BDC ( )Tj EMC (\(61%\))Tj 0.25 -1.2 Td (8)Tj /Span<>> BDC ( )Tj EMC (\(12%\))Tj 0.629 -1.2 Td (1)Tj /Span<>> BDC ( )Tj EMC (\(2\))Tj /T1_3 1 Tf 8.863 5.999 Td (0,04)Tj /T1_1 1 Tf -51.813 -7.432 Td (\215\024\035\027\t\005 \023\026\021\024\n\024\030\235\024\035\024\020\017\ \004\036\f\022\017\005 \024\021\r\036\021 \(pCR\), )Tj /T1_2 1 Tf (n)Tj /T1_1 1 Tf ( \(%\))Tj 31.691 0 Td (9)Tj /Span<>> BDC ( )Tj EMC (\(20%\))Tj 10.88 0 Td (5)Tj /Span<>> BDC ( )Tj EMC (\(8%\))Tj 9.382 0 Td (0,05)Tj -51.953 -1.433 Td (\223\026\f\021\024\021\026 R0-\030\036\036\022\006\017\005, )Tj /T1_2 1 Tf (n)Tj /T1_1 1 Tf ( \(%\))Tj 0 -1.2 TD (R0)Tj 0 -1.2 TD (R1)Tj 31.441 1.2 Td (41)Tj /Span<>> BDC ( )Tj EMC (\(91%\))Tj 0.5 -1.2 Td (4)Tj /Span<>> BDC ( )Tj EMC (\(9%\))Tj 10.13 1.2 Td (59)Tj /Span<>> BDC ( )Tj EMC (\(89%\))Tj 0.25 -1.2 Td (7)Tj /Span<>> BDC ( )Tj EMC (\(11%\))Tj 9.882 2.4 Td (0,9)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 9 0 0 9 42.5197 298.7749 Tm (\020\004\206\f\t\204\004 6.)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf ( \255\005\211\026\002 \006\026\t\024\n\024\026 \033\n\023\021\020\004 \n\ \024\027\031\024\n\027)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf T* [(T)48(able 6)16(.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf [( Com)16.1(plete responses rate)]TJ ET /GS2 gs q 1 0 0 1 42.5197 283.4729 cm 0 0 m 227.022 0 l S Q q 1 0 0 1 42.7697 272.2537 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 269.5414 283.4729 cm 0 0 m 85.906 0 l S Q q 1 0 0 1 269.5414 272.2537 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 355.4475 283.4729 cm 0 0 m 85.906 0 l S Q q 1 0 0 1 355.4475 272.2537 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 441.3536 283.4729 cm 0 0 m 54.108 0 l S Q q 1 0 0 1 441.3536 272.2537 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 495.2119 272.2537 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 42.5197 272.0037 cm 0 0 m 227.022 0 l S Q q 1 0 0 1 42.7697 260.7845 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 269.5414 272.0037 cm 0 0 m 85.906 0 l S Q q 1 0 0 1 269.5414 260.7845 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 355.4475 272.0037 cm 0 0 m 85.906 0 l S Q q 1 0 0 1 355.4475 260.7845 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 441.3536 272.0037 cm 0 0 m 54.108 0 l S Q q 1 0 0 1 441.3536 260.7845 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 495.2119 260.7845 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 42.5197 260.5345 cm 0 0 m 227.022 0 l S Q q 1 0 0 1 42.7697 249.3232 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 269.5414 260.5345 cm 0 0 m 85.906 0 l S Q q 1 0 0 1 269.5414 249.3232 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 355.4475 260.5345 cm 0 0 m 85.906 0 l S Q q 1 0 0 1 355.4475 249.3232 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 441.3536 260.5345 cm 0 0 m 54.108 0 l S Q q 1 0 0 1 441.3536 249.3232 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 495.2119 249.3232 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 249.0732 cm 0 0 m 227.022 0 l S Q q 1 0 0 1 42.7697 237.854 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 269.5414 249.0732 cm 0 0 m 85.906 0 l S Q q 1 0 0 1 269.5414 237.854 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 355.4475 249.0732 cm 0 0 m 85.906 0 l S Q q 1 0 0 1 355.4475 237.854 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 441.3536 249.0732 cm 0 0 m 54.108 0 l S Q q 1 0 0 1 441.3536 237.854 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 495.2119 237.854 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 42.5197 237.604 cm 0 0 m 227.022 0 l S Q q 1 0 0 1 269.5414 237.604 cm 0 0 m 85.906 0 l S Q q 1 0 0 1 355.4475 237.604 cm 0 0 m 85.906 0 l S Q q 1 0 0 1 441.3536 237.604 cm 0 0 m 54.108 0 l S Q BT /GS1 gs /T1_3 1 Tf 8 0 0 8 141.4158 274.8383 Tm (\200\006\t\213\b\004\220)Tj 18.753 0 Td (\020\025\020 \()Tj /T1_4 1 Tf (n)Tj /T1_3 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (60\))Tj 10.727 0 Td (\221\035\020 \()Tj /T1_4 1 Tf (n)Tj /T1_3 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (71\))Tj /T1_4 1 Tf 11.116 0.001 Td (\021)Tj /T1_1 1 Tf -52.572 -1.433 Td (\223\026\f\021\024\021\026 \023\024\035\027\024\020\024 \022\035\017\027\ \017\004\036\f\022\024\020\024 \024\021\r\036\021\026, )Tj /T1_2 1 Tf (n)Tj /T1_1 1 Tf ( \(%\))Tj 31.495 0 Td (14)Tj /Span<>> BDC ( )Tj EMC (\(23%\))Tj 11.238 0 Td (5)Tj /Span<>> BDC ( )Tj EMC (\(7%\))Tj /T1_3 1 Tf 8.841 -0.001 Td (0,008)Tj /T1_1 1 Tf -51.575 -1.433 Td (\223\026\f\021\024\021\026 \023\024\035\027\024\020\024 \023\026\021\024\ \n\024\030\235\024\035\024\020\017\004\036\f\022\024\020\024 \024\021\r\036\ \021\026, )Tj /T1_2 1 Tf (n)Tj /T1_1 1 Tf ( \(%\))Tj 31.024 0 Td (9/45)Tj /Span<>> BDC ( )Tj EMC (\(20%\))Tj 10.988 0 Td (5/66)Tj /Span<>> BDC ( )Tj EMC (\(8%\))Tj 9.98 0 Td (0,05)Tj -51.992 -1.433 Td (\210\002\013\026\016 \004\026\f\021\024\021\026 \023\024\035\027\t\b \024\ \021\r\036\021\024\r, )Tj /T1_2 1 Tf (n)Tj /T1_1 1 Tf ( \(%\))Tj 31.495 0 Td (23)Tj /Span<>> BDC ( )Tj EMC (\(38%\))Tj 10.738 0 Td (10)Tj /Span<>> BDC ( )Tj EMC (\(14%\))Tj /T1_3 1 Tf 9.341 -0.001 Td (0,001)Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\021\032)50(\b)42(\032\231\027 \213\036)30.1(\005\t\033)30(\b)]TJ 52.896 0 Td (LEADING ARTICLE)Tj /T1_5 1 Tf 25 0 0 25 512.0519 56.0378 Tm (17)Tj ET endstream endobj 2485 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.195 Tw 10 0 0 10 70.8661 529.9819 Tm (\212\031\016\205\023\022\024\026\024\020 \023\031\006\031\021\025\002 \005\ \n\023\022\021\020\004 \027)Tj /Span<>> BDC ( )Tj EMC (\032\026\003\013\026\004 \t\024\032\026\024\031\202\025\025 )Tj 0 Tw 0 -1.218 TD [(\253w)13(atch&w)13(ait\273)]TJ /T1_1 1 Tf 0.03 Tc 0.071 Tw T* (\215\024\035\027\t\005 \030\036\020\030\036\f\f \024\023\031\b\024\035\017\ , \023\024)Tj /Span<>> BDC ( )Tj EMC (\007\026\027\027\t\n \022\024\027\021\030\024\035\034\027\024)Tj 0 Tc 0 Tw (-)Tj 0.03 Tc 0.049 Tw T* (\020\024 \024\002\f\035\036\007\024\r\026\027\017\016, \r\t\016\r\035\036\ \027 \031)Tj /Span<>> BDC ( )Tj EMC (18/60 \(30%\) \023\026\006\017\036\027)Tj 0 Tc 0 Tw (-)Tj 0.03 Tc 0.063 Tw T* [(\021\024\r, )0.5(\023\024\035\031\004\017\r\001\017\b )0.5(\230\203\230 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 10.447 0 Td [(\031 )0.5(8/71 )0.5(\(11%\), )0.5(\023\024\035\031\004\017\r\001\017\b)30( )]TJ 0.333 Tw -10.447 -1.218 Td (\f\021\026\027\007\026\030\021\027\031\033 \216\214\230. \215\024\f\035\036\ \023\024\007\023\017\f\026\027\017\016 \017\027\235\024\030\n\017)Tj 0 Tc 0 Tw (-)Tj 0.03 Tc 0.27 Tw T* [(\030\024\r\026\027\027\024\020\024 \f\024\020\035\026\f\017\016 \220\021\ \017 \002\024\035\034\027\t\036 \024\021\022\026\026\035\017\f\034 \024\ \021)30( )]TJ 0.108 Tw T* (\b\017\030\031\030\020\017\004\036\f\022\024\020\024 \035\036\004\036\027\ \017\016 \r)Tj /Span<>> BDC ( )Tj EMC [(\023\024\035\034\031 \007\017\027\026\n\017\004\036\f\022\024\020\024)30( )]TJ 0.347 Tw T* (\027\026\002\035\033\007\036\027\017\016 \r)Tj /Span<>> BDC ( )Tj EMC [(\030\026\n\022\026\b \f\021\030\026\021\036\020\017\017 \253w)-12(a)15(tch&w)-12(ai)-24(t\273.)30( )]TJ 0.051 Tw T* [(\204\036\007\017\026\027\026 \(Q1, Q3\) \r\030\036\n\036\027\017 \027\026\ \002\035\033\007\036\027\017\016 \f\024\f\021\026\r\017\035\026)30( )]TJ 0.119 Tw T* (24 \(14; 28\) \n\036\f\016\006\026. \215\030\024\007\024\035\032\036\027\ \027\t\005 \030\024\f\021 \026\023\024\007\024)Tj 0 Tc 0 Tw (-)Tj 0.03 Tc -0.022 Tw T* (\030\036\027 \031)Tj /Span<>> BDC ( )Tj EMC (4/18 \(22%\) \023\026\006\017\036\027\021\024\r \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \230\203\230 \r)Tj /Span<>> BDC ( )Tj EMC [(\f\030\024\022\017)30( )]TJ 0.128 Tw T* (\004\036\030\036 6 \()Tj /T1_0 1 Tf 0 Tc 0 Tw (n)Tj /T1_1 1 Tf 0.03 Tc 0.128 Tw /Span<>> BDC 4.724 0 Td ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (1\), 12 \()Tj /T1_0 1 Tf 0 Tc 0 Tw (n)Tj /T1_1 1 Tf 0.03 Tc 0.128 Tw /Span<>> BDC 5.227 0 Td ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (2\) \017 18 \()Tj /T1_0 1 Tf 0 Tc 0 Tw (n)Tj /T1_1 1 Tf 0.03 Tc 0.128 Tw /Span<>> BDC 5.951 0 Td ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC [(1\) \n\036\f\016\006\036\r)30.1( )]TJ 0.081 Tw -15.902 -1.218 Td (\017)Tj /Span<>> BDC ( )Tj EMC (\031 3/8 \(37%\) \023\026\006\017\036\027\021\024\r \017)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\t \216\214\230)Tj /Span<>> BDC ( )Tj EMC [(\227 \004\036\030\036)30( )]TJ 0.138 Tw T* (6 \()Tj /T1_0 1 Tf 0 Tc 0 Tw (n)Tj /T1_1 1 Tf 0.03 Tc 0.138 Tw /Span<>> BDC 1.861 0 Td ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (1\) \017)Tj /Span<>> BDC ( )Tj EMC (12 \()Tj /T1_0 1 Tf 0 Tc 0 Tw (n)Tj /T1_1 1 Tf 0.03 Tc 0.138 Tw /Span<>> BDC 6.003 0 Td ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC [(2\) \n\036\f\016\006\036\r \023\024\f\035\036 \024\022\024\027\004\026\027\ \017\016)30( )]TJ 0.29 Tw -7.864 -1.218 Td (\027\036\024\026\007\255\033\r\026\027\021\027\024\020\024 \035\036\004\036\ \027\017\016, \r)Tj /Span<>> BDC ( )Tj EMC (\f\r\016\017 \f)Tj /Span<>> BDC ( )Tj EMC [(\004\036\n \002\t\035\024)30( )]TJ 0.035 Tw 23.244 18.267 Td (\r\t\023\024\035\027\036\027\024 \b\017\030\031\030\020\017\004\036\f\022\ \024\036 \035\036\004\036\027\017\036. \215\030\017)Tj /Span<>> BDC ( )Tj EMC (\023\026\021\024\n\024\030)Tj 0 Tc 0 Tw (-)Tj 0.03 Tc 0.18 Tw T* (\235\024\035\024\020\017\004\036\f\022\024\n \017\f\f\035\036\007\024\r\026\ \027\017\017 \024\023\036\030\026\006\017\024\027\027\t\b \023\030\036)Tj 0 Tc 0 Tw (-)Tj 0.03 Tc 0.064 Tw T* [(\023\026\030\026\021\024\r )0.5(\031)]TJ /Span<>> BDC ( )Tj EMC 4.621 0 Td [(\021\030\036\b )0.5(\002\024\035\034\027\t\b )0.5(\023\024\f\035\036 )0.5(\230\203\230 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 11.948 0 Td [(\031 )0.5(\021\030\036\b )0.5(\023\024\f\035\036)30( )]TJ 0.09 Tw -16.569 -1.218 Td (\216\214\230 \002\t\035\017 \r\t\016\r\035\036\027\t \023\030\017\027\026\ \022\017 \030\036\017\007\031\026\035\034\027\024\005 \024\023\031)Tj 0 Tc 0 Tw (-)Tj 0.03 Tc -0.024 Tw T* (\b\024\035\017: ypT2N0cM0 \()Tj /T1_0 1 Tf 0 Tc 0 Tw (n)Tj /T1_1 1 Tf 0.03 Tc -0.024 Tw /Span<>> BDC 8.661 0 Td ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (2\) \017)Tj /Span<>> BDC ( )Tj EMC [(ypT3N0cM0 \(\023\024\f\035\036 \230\203\230\),)30( )]TJ -0.021 Tw -8.661 -1.218 Td (ypT2N0cM0 \()Tj /T1_0 1 Tf 0 Tc 0 Tw (n)Tj /T1_1 1 Tf 0.03 Tc -0.021 Tw /Span<>> BDC 6.043 0 Td ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (2\) \017)Tj /Span<>> BDC ( )Tj EMC (ypT3N0cM0 \(\023\024\f\035\036 \216\214\230\). \200)Tj /Span<>> BDC ( )Tj EMC (\024\007)Tj 0 Tc 0 Tw (-)Tj 0.03 Tc -0.093 Tw -6.043 -1.218 Td (\027\024\n \027\026\002\035\033\007\036\027\017\017 \023\024\f\035\036 \230\ \203\230, \023\024)Tj /Span<>> BDC ( )Tj EMC (\007\026\027\027\t\n \023\026\021\024\n\024\030\235\024)Tj 0 Tc 0 Tw (-)Tj 0.03 Tc -0.001 Tw T* [(\035\024\020\017\004\036\f\022\024\020\024 \017\f\f\035\036\007\024\r\026\ \027\017\016, \r\t\016\r\035\036\027 \023\024\035\027\t\005 \024\021\r\036\ \021)30( )]TJ 0.125 Tw T* (\024\023\031\b\024\035\017)Tj /Span<>> BDC ( )Tj EMC 3.98 0 Td [(\227 )0.5(ypT0N0cM0. )0.5(\200\f\036 )0.5(\024\f\021\026\r\001\017\036\f\016 )0.5(\002\024\035\034\027\t\036)30.1( )]TJ 0.083 Tw -3.98 -1.218 Td (\f)Tj /Span<>> BDC ( )Tj EMC (\023\024\035\027\t\n \022\035\017\027\017\004\036\f\022\017\n \024\021\r\ \036\021\024\n \024\f\021\026\033\021\f\016 \023\024\007 \007\017)Tj 0 Tc 0 Tw (-)Tj 0.03 Tc 0.133 Tw T* (\027\026\n\017\004\036\f\022\017\n \027\026\002\035\033\007\036\027\017\036\ \n. \204\036\007\017\026\027\026 \(Q1,Q3\) \r\030\036)Tj 0 Tc 0 Tw (-)Tj 0.03 Tc T* (\n\036\027\017 \027\026\002\035\033\007\036\027\017\016 \f\024\f\021\026\ \r\035\016\036\021 24 \(14; 28\) \n\036\f\016\006\026.)Tj /T1_0 1 Tf 0 Tc 0 -2.436 TD (\212\031\016\205\023\022\024\026\024\020 \004\025\032\205\032\202\025\006\ \031\t\013\n\202\n \023\031\006\031\021\025\002)Tj /T1_1 1 Tf 0.423 Tw 0 -1.218 TD [(\216\017\030\031\030\020\017\004\036\f\022\024\036 )0.6(\035\036\004\036\027\017\036 )0.6(\r\t\023\024\035\027\036\027\024 )0.5(\031)]TJ /Span<>> BDC ( )Tj EMC 17.135 0 Td [(41 )0.5(\023\026\006\017\036\027)]TJ 0 Tw (-)Tj 0.216 Tw -17.135 -1.218 Td (\021\026 \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \230\203\230 \017)Tj /Span<>> BDC ( )Tj EMC (\031 63 \023\026\006\017\036\027\021\024\r \017)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\t \216\214\230. )Tj ET q /GS0 gs 453.5432724 0 0 208.1510852 70.8661636 122.5958967 cm /Im0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf -0.037 Tw 9 0 0 9 70.8662 111.7959 Tm (\022\t\217\210\b\002\220 3.)Tj 0 0 0 1 k /GS1 gs /T1_0 1 Tf ( \213\023\n\013-\t\004\031\003\026 \032\031\016\205\023\022\024\026\024\n\ \027 \021\031\n\026\030\b\007\027\026\021\024\021\n\202\n \023\031\006\031\ \021\025\002 \033\026\203\025\031\021\024\n\027 \027)Tj /Span<>> BDC ( )Tj EMC (\202\032\205\033\033\031 \206\035\220: \213\216\221)Tj /Span<>> BDC ( )Tj EMC (\227 \005\031\016 \033\032\025\016\021\026\013\n\027 \027\n\016\027\032\026\ \024\026 )Tj 0 Tw 0 -1.2 TD (\016\026\005\n\023\031\027\026\021\025\002)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.05 Tw T* [(F)-16(igure 3.)]TJ 0 0 0 1 k /GS1 gs /T1_0 1 Tf [( Flow)11(char)-40(t of the results )0.5(of neo-adjuv)16(ant )0.5(treatment of patients in the CL)30(T g)14(roup: BPVZ)]TJ /Span<>> BDC ( )Tj EMC [(\227 without signs of a retur)-13.9(n of )]TJ 0 Tw T* (the disease)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0 72.343 TD (\020\004\206\f\t\204\004 3.)Tj 0 0 0 1 k /GS1 gs /T1_0 1 Tf [( \207\n\033\n\t\024\026\027\023\031\021\025\031 \030\026\021\021\020\004\ \021\031\033\n\t\032\031\030\t\024\027\031\021\021\020\004 \032\031\016\ \205\023\022\024\026\024\n\027 )0.5(\027\020\033\n\023\021\031\021\025\002 \n\033\031\032\026\024\025\027\021\ \020\004 \027\003\031\001\026\024\031\023\022\t\024\027)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0 -1.2 TD [(T)48(able 3.)]TJ 0 0 0 1 k /GS1 gs /T1_0 1 Tf [( Com)16.1(par)-37(ison of d)26.1(ata on the immediate results of surgical inter)-41.6(v)13.1(entions)]TJ ET 0 0 0 1 K 0.5 w /GS2 gs q 1 0 0 1 70.8661 715.181 cm 0 0 m 225.39 0 l S Q q 1 0 0 1 71.1161 694.3618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 296.2561 715.181 cm 0 0 m 96.232 0 l S Q q 1 0 0 1 296.2561 694.3618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 392.4884 715.181 cm 0 0 m 96.184 0 l S Q q 1 0 0 1 392.4884 694.3618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 488.6723 715.181 cm 0 0 m 35.737 0 l S Q q 1 0 0 1 488.6723 694.3618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 524.1594 694.3618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 70.8661 694.1118 cm 0 0 m 225.39 0 l S Q q 1 0 0 1 71.1161 682.9005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 296.2561 694.1118 cm 0 0 m 96.232 0 l S Q q 1 0 0 1 296.2561 682.9005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 392.4884 694.1118 cm 0 0 m 96.184 0 l S Q q 1 0 0 1 392.4884 682.9005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 488.6723 694.1118 cm 0 0 m 35.737 0 l S Q q 1 0 0 1 488.6723 682.9005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.1594 682.9005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 682.6505 cm 0 0 m 225.39 0 l S Q q 1 0 0 1 71.1161 671.4392 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 296.2561 682.6505 cm 0 0 m 96.232 0 l S Q q 1 0 0 1 296.2561 671.4392 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 392.4884 682.6505 cm 0 0 m 96.184 0 l S Q q 1 0 0 1 392.4884 671.4392 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 488.6723 682.6505 cm 0 0 m 35.737 0 l S Q q 1 0 0 1 488.6723 671.4392 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.1594 671.4392 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 671.1892 cm 0 0 m 225.39 0 l S Q q 1 0 0 1 71.1161 640.7779 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 296.2561 671.1892 cm 0 0 m 96.232 0 l S Q q 1 0 0 1 296.2561 640.7779 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 392.4884 671.1892 cm 0 0 m 96.184 0 l S Q q 1 0 0 1 392.4884 640.7779 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 488.6723 671.1892 cm 0 0 m 35.737 0 l S Q q 1 0 0 1 488.6723 640.7779 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 524.1594 640.7779 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 70.8661 640.5279 cm 0 0 m 225.39 0 l S Q q 1 0 0 1 71.1161 581.3167 cm 0 0 m 0 58.961 l S Q q 1 0 0 1 296.2561 640.5279 cm 0 0 m 96.232 0 l S Q q 1 0 0 1 296.2561 581.3167 cm 0 0 m 0 58.961 l S Q q 1 0 0 1 392.4884 640.5279 cm 0 0 m 96.184 0 l S Q q 1 0 0 1 392.4884 581.3167 cm 0 0 m 0 58.961 l S Q q 1 0 0 1 488.6723 640.5279 cm 0 0 m 35.737 0 l S Q q 1 0 0 1 488.6723 581.3167 cm 0 0 m 0 58.961 l S Q q 1 0 0 1 524.1594 581.3167 cm 0 0 m 0 58.961 l S Q q 1 0 0 1 70.8661 581.0667 cm 0 0 m 225.39 0 l S Q q 1 0 0 1 71.1161 569.8553 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 296.2561 581.0667 cm 0 0 m 96.232 0 l S Q q 1 0 0 1 296.2561 569.8553 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 392.4884 581.0667 cm 0 0 m 96.184 0 l S Q q 1 0 0 1 392.4884 569.8553 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 488.6723 581.0667 cm 0 0 m 35.737 0 l S Q q 1 0 0 1 488.6723 569.8553 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.1594 569.8553 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 569.6053 cm 0 0 m 225.39 0 l S Q q 1 0 0 1 296.2561 569.6053 cm 0 0 m 96.232 0 l S Q q 1 0 0 1 392.4884 569.6053 cm 0 0 m 96.184 0 l S Q q 1 0 0 1 488.6723 569.6053 cm 0 0 m 35.737 0 l S Q BT /GS1 gs /T1_2 1 Tf 8 0 0 8 165.4863 701.7463 Tm (\200\032\022\032\215\036\020\022)Tj 19.979 0.6 Td (\027\006\210\212\212\004 \020\025\020)Tj 0.993 -1.2 Td (N)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (45)Tj 11.022 1.2 Td (\027\006\210\212\212\004 \221\035\020)Tj 1.004 -1.2 Td (N)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (66)Tj /T1_3 1 Tf 9.355 0.6 Td (P)Tj /T1_1 1 Tf -53.796 -2.033 Td (\215\030\024\007\024\035\032\017\021\036\035\034\027\024\f\021\034 \024\023\ \036\030\026\006\017\017 \(\n\017\027\), Me \(Q1, Q3\))Tj 30.857 0 Td (180)Tj /Span<>> BDC ( )Tj EMC (\(148, 195\))Tj 12.026 0 Td (180)Tj /Span<>> BDC ( )Tj EMC (\(156, 208\))Tj 10.332 0 Td (0,56)Tj -53.216 -1.433 Td (\025\030\024\r\024\023\024\021\036\030\016 \(\n\035\), Me \(Q1, Q3\) )Tj 31.357 0 Td (65)Tj /Span<>> BDC ( )Tj EMC (\(30, 100\))Tj 12.026 0 Td (60)Tj /Span<>> BDC ( )Tj EMC (\(30, 100\))Tj 10.082 0 Td (0,8)Tj -53.466 -1.433 Td (\212\024\f\021\031\023, )Tj /T1_0 1 Tf (n)Tj /T1_1 1 Tf ( \(%\))Tj T* (\035\026\023\026\030\024\f\022\024\023\017\004\036\f\022\017\005)Tj T* (\024\021\022\030\t\021\t\005)Tj 31.937 1.2 Td (33)Tj /Span<>> BDC ( )Tj EMC (\(73%\))Tj T* (12)Tj /Span<>> BDC ( )Tj EMC (\(27%\))Tj 12.026 1.2 Td (39)Tj /Span<>> BDC ( )Tj EMC (\(59%\))Tj T* (27)Tj /Span<>> BDC ( )Tj EMC (\(41%\))Tj 9.503 2.4 Td (0,3)Tj -53.466 -3.833 Td (\200\017\007\t \024\023\036\030\026\021\017\r\027\t\b \r\n\036\001\026\021\ \036\035\034\f\021\r, )Tj /T1_0 1 Tf (n)Tj /T1_1 1 Tf ( \(%\))Tj T* (\207\215\224*)Tj 0 -1.2 TD (\207\202\217**)Tj 0 -1.2 TD (\203\215\217\215\025)Tj 0 -1.2 TD (\215\217\215\025)Tj 0 -1.2 TD (\224\r\017\f\006\036\030\026\006\017\016)Tj 31.937 4.8 Td (11)Tj /Span<>> BDC ( )Tj EMC (\(24%\))Tj 0 -1.2 TD (10)Tj /Span<>> BDC ( )Tj EMC (\(22%\))Tj 0 -1.2 TD (20)Tj /Span<>> BDC ( )Tj EMC (\(45%\))Tj 0.5 -1.2 Td (4)Tj /Span<>> BDC ( )Tj EMC (\(9%\))Tj T* (0)Tj /Span<>> BDC ( )Tj EMC (\(0%\))Tj 11.526 4.8 Td (22)Tj /Span<>> BDC ( )Tj EMC (\(35%\))Tj 0 -1.2 TD (12)Tj /Span<>> BDC ( )Tj EMC (\(19%\))Tj 0 -1.2 TD (31)Tj /Span<>> BDC ( )Tj EMC (\(44%\))Tj 0.5 -1.2 Td (0)Tj /Span<>> BDC ( )Tj EMC (\(0%\))Tj T* (1)Tj /Span<>> BDC ( )Tj EMC (\(2%\))Tj 9.003 6 Td (0,3)Tj -53.466 -7.433 Td (\223\017\f\035\024 \f\235\017\027\022\021\036\030\024\f\024\b\030\026\027\ \016\033\013\017\b \030\036\036\022\006\017\005, )Tj /T1_0 1 Tf (n)Tj /T1_1 1 Tf ( \(%\))Tj 31.937 0 Td (34)Tj /Span<>> BDC ( )Tj EMC (\(75%\))Tj 12.026 0 Td (43)Tj /Span<>> BDC ( )Tj EMC (\(65%\))Tj 9.503 0 Td (0,4)Tj /T1_0 1 Tf 7 0 0 7 70.8661 558.1207 Tm (\032\025\003\031\006\026\021\025\031: \213\230)Tj /Span<>> BDC ( )Tj EMC (\227 \005\032\007\001\021\n-\033\032\n\003\031\204\021\n\t\024\021\026\002\ \r\013\t\024\025\032\033\026\203\025\002, \213\201\212)Tj /Span<>> BDC ( )Tj EMC [(\227 \005\032\007\001\021\n-\026\021\026\023\022\021\026\002 \032\031\016\ \031)0.7(\013\203\025\002)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\021\032)50(\b)42(\032\231\027 \213\036)30.1(\005\t\033)30(\b)]TJ 52.896 0 Td (LEADING ARTICLE)Tj -52.896 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 23, \023\0221)69(, 202)69(4)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 23, \023\0221)69(, 202)69(4)]TJ /T1_5 1 Tf 25 0 0 25 27.2775 56.0378 Tm (16)Tj ET endstream endobj 2486 0 obj <>stream AdobedC     '$''''$25552;;;;;;;;;;w   q!1"ARST#45QUaqtu2B$ %&'()*36789:CDEFGHIJVWXYZbcdefghijrsvwxyz?Q>ob5ٚF!ֱC <1$d`o*o: Wkwp+=_c}{: Wkwp+=_c}{: Wkwp+=_c}{:5Գ6i#a-ysDDDDDDDDDDDDDDDDDDDDDDDDDDDQNx7ǫ+dD_弯6ڬG+%c)Ս-y߹jt٧SACpJh h"47n;WH]=,)hQNx7ǫ+dD_2; (}x="۸!9KZ ZY e~ڙ- /kHn|fN]=,)hQNx7ǫ+dDTX5Ҟ  ̯{d{\lkF֑B׼H]3_=lq绝Ȣ:95`:mc ʼn\#۬HV]=,)hQ?b}*ַ;a*{O'!kRu\~nޞq qN??z{7UOq~{P`W=u\~nޞq qN??z{ؕ)GNfX{ɻɛVQ|I,Pe{X +φu NO׷6Oou8m>^p}>.|]{{iSu NO׷6Oou8m>^p}>.|]{{iSu NO׷6Oou8m>^p}>.|]{{iSu NO׷6Oou8m>^m|2S>ފ_-{p}>.|]{{iSu NO׷6Oou8m>^p}>.|]{{iSu NO׷6Oou8m>^p}>.|]{{iSu NO׷6Oou8m>^p}>.|]{{iWs6b&\?0DDDDDDDDDDDDDDDDD@QPئ/OH5i6K͕Xp1jB@{kF[yI^9`ͯ{7 C.ԚdφY:ۋ@'ݫDDDDDDDDDDDD\x*5 4)3d,ِIe#fDDDDDDDDDDDDDDDD@QsԵNlŵ+j`n)ºb֧]E_GSpأ8WQWQ+(jqNU~8 *?ZSu~N)ºb֧]E_GSpأ8WQWQ+(jqNU~8 *?ZSu~N)ºb֨> #m썍pxȀ!VhtXl=h&rhvYϕzm*G I?,|Y'ү$pбdJBŒpm*G I?,|Y'ү$pбdJBŒpm*G I?,|Y'ү$pбdŰWj^,nc&WTq39i?,|Y'ү$pбdJBŒpm*G I?,|Y'ү$pбdJBŒpm*G I?,|Y'ү$pбdJBŒ㵭mU,C< ֐k:.c,y^aa$sB9ѰKI$I+(j =i!(qpz8"d1tPUlgPsx>2&yE,7roאFdpe! ɚۛgܔ\[,Z@9NcWF+RWk=o[5*hc,c#cmq9dqIkh2c \ t *?ZSu~Qa|1G,5aOU̍px*QHUJRGuYz<=Y`v؝V)laCuw[mFlp2Ϟ=:KL[3DZڟ76>zb&2M`ǵk݅,D ^h sVb~g|JZ""""Kΐ~-D{wXRD|JH?TjdsƗ%o)5];4k^5$9gksT`f#j-ԟQٲ Wa A;pqӮ9F~nNzdS^ůVm6l>ťEM9l,m^|f c| sٛJz-sLta604,wV5<9ٯL[Fk&XY0I$oRfď߿E2*ѧى1xڮ~D˪}v;f* R;U69ّy;=T 7Z͙+rsG/q&\4:]#DTg-:f'2Nm!H3~'r- Φb5r<ϐkcx=Ryf1`iĀyW} 5fs!߸n;7ad.C4rMkr>ݖdOl f&ˢ:xל^On6g dٓsCw*lC#- lp̏4@iLDQ.fDDDQ0y/5ik- A ŚX]7Xծdѐ8SjG&FZc5lk^H: rѼ W1 Z ׌AJm}XKb/ac ɆFF˹zǍSbn.|,šFN{Q1? 3t>%-QHUJR J~WCJVĘm A6Δ4ɨKA'~Mf3/,dFsȝ`FJ\2(,5isy2TFccaoVvRIP'fu여fSX,gh%-D|JH?TjV6os{GARE^ՕIlP7V#r2#O 0Wc_x9uZk<&Z`6%X`-TdGlkvؽ&K{$~QqsaԴ>6{d0vDAi#27Qʿ]16u_o&˯~q៹Grԣ%"f7ٕ5"ڤ87R(؅RQbOWlLc p2cnU`%+8\ sDUXa#6.kk޳(._u4o{pHV:\IByck5I:ۋ9tR>8I sbM@ݦd,$:1[am㯱sΤfmawxcX;OF+X0f,5X\f5y=Ĩt]iH]jXUuai!gr°E|=;z.&fr!DQ.fDDDQ0yK"-Q > gư]# #wU9[dD%k7f5Vpwe?uCwXcs%2Cb G+!ncjFYflRtoOOl8^`X*Ώ, “ed/hO1|S٩ ʼn{aBFCs d؎3C nkV#S!;Nlv­ޘ9ZTZW=--Sy]Z(~QHUJR/g !p230T<\/8|v%j5WTd;2MٖyroY r^viؔd+NF\xr;֤,^J48떺\>cwX 9w9Ԁ:mC6?0I o~ 6c4ŭI w7=㒻EoE1TdlKs$5174]in!Ws^2CvG?Po>2,˭UCiO!s틫L؞˪Ki; $՝=T5-;ndWk\i9Y<xlKǤIuy"ek-{'rwآ(~a>%R5KDD_ȿW@;~V(<`052b-sK5dsߟ;xSpDDDDDQ.fDDDQ0y/)l׆X`Xs+Z^3_\ճ_ Yk,7{(#shv^8| SB4:)9 yեZ2&:\!kh9W'ƒ7oֱ.sZy +Kj7l-28TvE#VAo31k"YnѶZ#ٰͮkKKr">KzE-L'Ī^tFhćڢ(80Rǐ:X<֏{3d"*QлZ%-~Yf9vy!M°ݶ%- , ]MilnNg}]]+eaPNK6[G.uQ..n/єM^A&î?1ݫtE%R5zEv |Dfx͠.f|CZ'bFm.|5y$ Zd!#KYp)R5N"deo#vh=zpO;48~'d^Nq ֿ2J6jگdvn;cN췅%G%=Ix0` k]̐jN{jGF0r@sa,ۛn#R6>ijH[=g4dṬcZFUTb瑐`$1JZ]'<|e㎝oǀ2_(l42rߞ|ٯ+CEp7VL7g1]4;e* dҌ$& ixd hvpg n69cuwM41\] ۼr׮XV Jܯs4SQ&؇ce{e.y9 2LOJcJ<8.2k绢Q{,4MH}mu0axCk°aÔ2浍`9K<Z{v]e@5eK\O;=\OnqN unl3'Y;T;?0m"1otmY^jQ q\3T m0 ^0߈p&=v@ǹև5'ks.ƨQD]HCk$8r?c-]a8;%+dSf34k04j H$Rmӭfx5,%烑qK=ɠudk֕8cېk-3 !F,v&blļ:VvʦM$DVGbMtJ6pRw`CG< TK'uWԳ4k:Q#^X #,ώQU8&E"֭N[͝~Qn_W|3Cn Z""""""(,no8)ȈQEU R""""""""(OT_5nܽ$ [H- I#gnVpȂ2 if]Pd܁Ե$Qlv59rR5Fe_LcL떍l<1G7۵t^o@1578盇_H#9i2^94q1Ik@se~aWf܋ezn{A @04ldn aUcXgfW *!5 hk,nC&ɐ#<@`66F{_.U ne,<˔{k}TblPj,f y7ȒW.&?fsYڧʶN66{kJI/ycu <ѐ|=,)hŹL"""""""""""""""""QEU R""""""""(OTRmIb8v4cs\#u@_2C*˞GHq:󻤘]>9O nh|.hhkٓ7 7xMfx( lem&2o_ZSbXlÉJ':f:\1=;S7ʸ# l~4-RE{5nSqU*tkiK~D's fɹu2 V6m= b85}wγ٭Y]lSZryR8p-IeYԺءbãQ6Ѳj5ڭsYsׄiLJJ裊kv;IHk== 21rIF%Qd.g Y##@J"ǫg3M:7e q -397.9 xb~pm]|gQ'RҺ.kMb|Nũ\+X[! dh"Xñ+̝&ɒXro+*gl.nv~ 3b{eq=D{wXRx#W NO׷6Oou8m>^p}>. ̯Gi@nY&$rjg NO׷6Oou8m>^p}>.|]{{iSu NO׷6Oou8m>^p}>.|]{{iSu NO׷Eʎ!2II*DDDDDDD@QEU R""""""""(OTR{p E+j> VlRf^^C`SKLp,""hՍ {C{fY!kvdȒ6)Tcx+"6gI$Ǜ;6{DŽaE+LW@.{rݼ'Dk/mo3lu5hH xe%wdQ۬j43 ːx 5𽮒Iex0&뜆y Skd̒XN&76A;/p3Վׅк8mkL.k"9 FKL seY $A7-suDeȤVHP\\Lgysy\޽QD|JH?Tj ձ.ֿf*NlKHlLF@ kƎ}z>Q0F縑neY4m0p[`ڎg-00R&!V7W;Loqi1^,<;Ybm4̵eķ{fyfNw,Zzv̆̑8n'2A+јKRu1Cb(Z\ǽѹȼ@<& ^Wb{pڐ\[]w!yEnRm{UIJ<ĭ)u3<-yDqYm!ZZ ԎK-9ݑ⽰ðF Jsd4uyWH]+h%̜-{S"݈6[Y0NֱٗFdhsX\3{Yʖk]HψÈ;WW0o-}y+߰ʯIG(~N1/qvAܾVQ)<0A./4ַzxhEK8ln&93I'm^#\ݳ,# B j\5y]|wD1 7r 'y6 5u f#N`2Uk0p"-g3GZN,,]e zmp+@a`k"ck55@/?1X"w4RQ_Q_Q_Q_Q_Q_Q_Q_Q_Q_Q_Q_Q_Q_Q_Q_Q_Q_Q_Q_Q_Q_Q_n<ٞ'6  lq:2Ic3?w7"x}©U"*:UU_<1:6ثؙ2s^Wtj9;@ff079s_+!4V1˞scp`yrzҌ)ڕwkئ|NQ ʶDEMVi)-[l졍^2Nye6g X̆jk aMI+ظv|"*nuY85nD{r'w*DDUA5G!X QD<,=TDDDDDDDDDEqƽWgS8.U28dqϰIrf2#~~^Ħk S^GlO6d,C,.b2ךLT9L6M3O0#.wGG[GYarWڅ+92w;{Gr.F< q0F/ oUnnZ5˓>\2#̍/(/xxƎqŕoOBl |b߬97^|rvM4m!|dR5]84.)IZ(ۃA##G[j]e/j5;xu*ޡLe"Ww~x=lBbd7ݪA#y_ $P"h呐*6ax`9Lȼ*J-hK89$,|K|*Xݴ yx(|g.'.LQU+^FΑۋeĞWnR~xoHVQ~ @fI^\.Nou8]^^p:>uzt}{{SW-G;hʣ ZVdj0%kme?"8]^^p:>uzt}{{S ӣ_q˪C6 Ebxف,5v1Zր NdednI'q @ivG5sV]JbI]QF״=ו؜MB|BƴI89<@NS!g3#4,栗_۵v\n˞ZwmK6|ݘ4UN`1PFvYWMFWtV q6GFxC>2̉l ~xoHVQTg+wdR :?Z^i\0Y-lwׯ]Ѱ<9̹9S3GPV!SǴ&;VP srH~G$UU3>0o+L?-j֎&flnU~z1re~;ZUw#Lq0en rʭnh<-r~,@e"8f&`g~g+0@kIŸw.FH[& ǻ._qPoq]7[i5C9g[2CMs*x°3y?ZV[2I߸=M*%LnŵԬ=fk/il ~ /Oil ~ /Oil ~ /Oil ~ /Oil ~ /Oil ~ /Oil ~ /Oil ~ /Oil ~ /_EpI.9.o [_K[_K[_K[_K[_K[_K[_K[_K[_K׾ u!fX . fI*r""""""""""*Cٵphו!exi=~ؓi=~ؓi=~ؓi=~ؓi=~ؓi=~ؓi=~ؓi=~ؓi=~ؓi=~ؓi=~ؓi=~ؓ쵑><9g6 ODEhyޑaKDDDE<[hds3XĪtfjal?CPsܛ3$8Nۣדt#FaTGQK"@ْ3h>y"|w'%H.HXѶwRư\^LpIoX}n 3bv \r;wY$Y}"*_g,h:m Y)xJFeZ1ph. fcs- xn:Z8d!X_S:qZkӘ[vɑ#w1?%{ m M[uXkEfYlnk/nqN~{KƥGZSbH!tAOVnp~70NP;=|`@Ӳ5l2x 6gv\#ZĩՊgj b(\C+$s$\ÜQ ;>/Ѽ>R5k '˛ =c<*)!+Kd,{O(sXG ?lyүTDQ#Vǝ*eK\Rj&6^c|fm=\O!RiFH1[r fyY7djjϚ6 r;#v< vȩ^Gbt:cA{sEfaNI^c+t5լk6͆W.Nvf%0Ť]DdݮDŽrɩמ%Qf{hǹ2\yͧrbψ¯XkuG2.vgoWS]fm̹JcdTg̞ruƶhY^`Q0 ?w=>U-KzE&InC4fJt]@Ξ'9`,;<`/q|3JdtM~Q]3=h)fȸdwgzǍNfM1] S#wnܹr/:CbVFg4SWsWhͫf3^54Z{y!||35&sۯKK͹)1tYٺրjҹpnrü^qct XV}2Wd\!̷/{r,KHZ&dve$dW:(AF@޾0|R6BV> >}A vNsnaɼdO(F> ngucSl̚0]x-av0ό=Fm$d|b1*t611!uq.w+F@s_QXdN 8̕`fл"37^..&!I_48'l.&0Hcy;0J6XiU0_Y9N^7*tƟ#B'`"$7hͫGծB wc^\]$^մYSldA2 sfӘݼ/6;6Mbλ2k1fM۷oQzȰ{rC0fxdnn{+X#ŝ6~mStkpB@QTg+wdVȼmVͻcɐX7>\9"=mwT+\_Șآhcֵ5p dD[t-HUJR;cF,±,1kh93#SL3OKDDDDDDDDDDDDDDDDDDDEhyޑaycXM:tfkippy%ulolu߂͆BܝYd GF|e}ա>'Ie&^U)TtSأϮX疽=c~? ũ_z6-ZN8mzrEĄޑ`۽46iEhǪ5nŻwXjYAۮY$✸9ip:$eVQлu d7C7jEYI1W &bK : dw>h,1sוM0wP,awg";KQ WvxLufbtDCG2NG.$Y98M߅aa73RI샄= B >8+As4lqG scUs ?C]ڄRl387s%vxϟNc&:RMcO#tv֒AsJփr ږä:J̞b5ea[!2Va~/nK"'[t2 a9ֳgA|crCGmΚ(YsbwJ%<Է=nM  h e||4hǚ ҆b-:bp58<0ֈ23$~bU41%׌H]yN:[2=ʯ"y#8[^jh9RtkEz2X6i#[s ]nͭ'UI&flO 11>@D`i5F0)R̖ /٭4fr \^2csO(dv wT dԎ 9.ܼq a5!kѻ04kpB@QTg+wdVȈJ&abZvV$ύچs7k l[fVL&|:5v f*C>|PGiKZYē5~F=b YVɤd+ m, t09oi2HUJRD[t-|썎Gq y9׾dlPy &3-iN94f3C#;3_a8fN".nЏ7<_-E>&XFC^4_bx bFj mm]}\ߗ] l..sCC9ۆY6'wLl-aH\h#?nsݯg]D&^#/hyqgyr^L~1:e uelf.p9p$k4fINɦX̲H^f3n j"? QTg+wdVȈj$3uYLDO]_M4m5Ǘp%/1z`׹-!9'4/^rO%FFeGsKAp`9r HUJRD[t-FajC9%+93s@{OD:o)R..p[3l:GC&gTز Ϛ;/ ~Zd&V'\ma$熆CyI9r/ `m60ٰіTԉ#7*Hsōݭ2'[;lLxtubVٷd ڣ']we82V '6weQpIL#S}s,E]45{ND5&*Eq %idU[f e[Շ\ r`Yxk$i{#2}T1bZ~x[fFaFX[pR[İO8,m䯴kFA<֢"xY{h]=,)hLk{0[USa m+g9rU4[56W0mmbkǛ=r7ȩU0GMbyWu6+6Gb8F=UM53ߪ$3{h7_P ( 56ޞǽEZLڇ~yy@V7XilM[dȦÖ{90U\m+={HЗ&eYs=V*N]_ /tmwsffN;Uml>l:T0ǰZ;dK&E7-FE @eb!XyDJDUA5G!X QTg+wdVȹf1)жڱWpx%sy!I[nAC^BEid .8\מ^\&WquD707*6ܳ=~Nw'=Vm}^:Wf|ɲϛ#HwE>ZX2d:Ea×e!4y MKl3-]ԋ"|  ^CEODp^Vt᷉'&Id G&g]sB&†Qjܺ2 96vK "|ll9QeX+Tdĉs)\3/?.xo#(#nd18Z0UGL3mc82 yD[t-HUJR~ \dA nVI bWa~Y绗>rf1șDQ0 ?w=>U-KzE-|F5pwA/E26Fƴd}"* #QW Y`*Og L7YFfH2yx#!0N9|;&I+~tba<'fN+z XGCXֿ 5 L>Ab T(T;"[-%L2v/KAj0:1nZB󅹍 3 o-Nh+42#F~9z(VT轫qWgWqSMy٬W4KN6Iml۽vi|1;X{=)!{b{qc$:=űLJ7>C Xl3+;T1䓻5g^oŮp+PkіN#ICBZkX1ħ8؆áՌpwkHcb2#Xa&gK(KbXtNEPn$7fË7^@DLuC 3>v{Ԝ3 u,t7yT^X FΌDz-ɻ PDQ0 ?w=>U-KzE-v s$&\&!o/+㗛%ZVV1;쩸Ƽ4sĘiDqíX^va;&F\y(^b,T>fjCRFzt[AsG& :r[װ] 'e$nd67rbfۂLam{xl2@#q,+É$oh rۡ|ņCjMtFnk=k;GTgqkn (YdWesp>6jA™5"]xYn޴@c{Ir;ϔ~?5w !s)WY2և@_#lbPpW1.7Ii #6"d-7㩘k7 k/{N{"1t\Z2Xf(צYePh18E ɀ̒Yz[2tKt[6q'.q_|j#j' 5b-tUmKd{#P>&->U^Y£cMγNH.?7sZrj܍.n/bM~L{Ih]sg9ʕwںLřqi-j 嗔asv!,E&o2k[񸵣<@Ha2]+2bKEpȌ#YJNor/ZsO5\Fl>JϷlzXds i˗ǥ3pjA8[,=`{su\s|C!VYbʍdMhk%X 9d,1 |Yf;s"Β@ֵ临Ϝ~xoHVQEü.<DDDDE?lyүTE$0ͫc_;UpϐqGEdcL<\쵲<޾k 5K#גpaqh'2|Dɢ9F9pBL3OKDDDDDDDDDDDDDDDDDDDEhyޑaKDDDDDDDDDEbA%isF3#6W^2&5Mh P_hHCrW99H1̝sQi(x4v+ $0p˜ƒ[/X.16 \"Luե$Ԓ0)4umɍs[3㮴|Ȇ2[|A4k"7\s@#ۃIb6ك֎njK}Kk4R[^lnݞyq]' tr^,92kѹGchENfќ:vX3I d{CGy/+;,AQ`}$kǯ qg7&p.y5߳_QLڹ>rDE sRD{wXR~xoHVQyZ*ܲ5|CX\nxnkY$:ֳIu gؓt;Zϱ',vbN3Xk>Ĝe_}ThռJ[ ϔܰbԩ;F̼f/r$(dηAcqnkY$:ֳIu gؓt;Zϱ',vb^Ae-p\r{[O"DE?lyүTD_%qkKm$A,ǍVF"֑˭士V{cZ-ikre}lnO$d2q;~:y]E'K+ τ9C50\7}10k!27|9O !pWdR -mBuJj iϞ0ƃG#|آhkf@5Fy7/aé5! ϐ@/dDE sRC d&{fC+_g[}8ηAcqnkY$:ֳIu gؓt;Zϱ',vbN3Xk>Ĝg[}8ηAcqnkY$:ֳIu gؓt;Zϱ',vbN3Xk>Ĝg[}8ηAcqnkY$:ֳIu gؓt;Zϱ',vbN3Xk>Ĝg[}8ηAcqnkY%xm$U$s`nQTg+wdVȈG⭏:U^ʖ$~*_h+Xq*xvb`$J[0굯<̻>_;#Sƍnj9d΀= XvM>B3K+&6X.W9r؊0}ҩVNV#1iZV&|!ѵN9rXSگai &lf2g{w2DE\My٨#y:-'b2>M4Y˓:[˘k)-^R4m6t0HZrϗa;n5pe1R<1/8tb81;lP:e ځ#c͍ͭ2ܹr/9|2Y2 ;|LܜFDF9e?wlG⭏:U^ʖ$pY4q"76H/ͷHAgE~דSgE~דSgE~דSgE~דSgE~דSgE~דSgE~דSgE~דSgE~דSgE~דSgE~דSgE~דSgE~דSgE~דSgE~דSgE~דSgE~דSgE~דSgE~דW:GdG9HrsYrtDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDD@QTg+wdVȈG⭏:U^ʖQx۫Rݤb|22fH \3<{={={={={={={F~gfHs1#7Zh Oӱ~X}'ӱ~X}'ӱ~X}'ӱ~X}'ӱ~X}'ӱ~X})T0qtbŷdmP H@""""""""""""""""""""""""""""""""""""""""""""""" QB|*>^Dj"""""""""""""""""""""""""""""""""""""""""""""""""" QyW]xc^DqK6Mqp1fZW,vbN3Xk>Ĝg[}8ηAcqnkY$:ֳIu gؓt;Zϱ(m袮j5k?6qnkY$:ֳIu gؓt;Zϱ',vbN3Xk>Ĝg[}8ηAcVcInno41A""""""""""""""""""""""""""""""""""""""""""""""QHUJR\?ܾzDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDQu{-Vx3*։k[6XgbkG?)-M{dY#=RrϜQX# z[V"0NKQ_Q_Q_Q_Q_Q_ 1kh˰ ?-XȏF@?gE~דSgE~דSgE~דSgE~דSgE~דSgE~דWfO,2G9pI*[8hg˗5qX[X=f1U _6Y6з"5Gh痌y7+g! ӓ#{9r;_7v= PՖ룖Զ_42h!<4kdQ1fGO+;Z17YdGnص.BڣkDpI b3v wNvV'lE837yMobXȭ֖9&udGfD>UY#nMZ'Ik̳SKzE-L[ītG/Z?U Ubx-UKrQQݳtlhcw ^xLX0,qF˫ g1izѼn^Z|1l'BcWgHE*q 䝇2\8oXl]fM6AZ#nF]9laJHP;Eq x Wl gf{#[jE_)j֋WnN#kVç tQ9@uyם[vS_ytNu 컴J|%>9)b6^NiN&٣)~ PǐFkcGbQ]g `sKb/=`Fw2D[t-k=]i[(X!5{h\NpXN|%yaxl133b䭐49pN֫6n<0r>&:vώgBr8EfݬsVo5%U:#YpԻ6'jܞtk"cckZ9I%@Fu;n{iV*݊X,s1k;xuv22ߗ-"V+]Y dn09ht߿yz`N6g+eck |6kkYz3cg0n9n- !>dp 9 vs*bw4sW+6mڵ-[ köyj=ٯl;p OkFصsT ?gĕ p83t FOy^pyh`p]#mVH^Z2vx>Ng"| # !#yI7AB^éRKo q$!s iO 5fҾRY GK#γ7;Y,~գêE, cv5\܌2I] =}f>Ը5p:Cm O+9n]2(cΕW""""""""""""""""""""""""""""""""""""""""""rxLƸb`^Zuzt}{{S ӣNWG׷.Nou8]^^p:>uzt}{{S ӣNWG׷ٞ mQlr1<rO9L[ītG%Kux,> ͦ{|a^WG׷.Nou8]^^p:>uzt}{{S ӣNWG׷.Nou8]^^p:>uzt}{{¼KY1=\HwDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDD@߆a=IR9Ĺtl$KyW]G_GSpأ8WQQ+(jqNu~8 :?ZSu~N)ºb֧]G_GSpأ8WQQ+(jqNu~}Bw+֊'喳;# Z#"B8WQQ+(jqNu~8 :?ZSu~N)ºb֧]G_GSpأ8WQQ+(jqNu~8 :?ZSu~N)ºb֯X*U|mk3< W"""""""""""""""""""""""""""""""""""""""""" endstream endobj 2577 0 obj <>stream endstream endobj 2458 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 2459 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 2460 0 obj <>/Font<>/ProcSet[/PDF/Text/ImageB]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 2461 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 2462 0 obj <>/Font<>/ProcSet[/PDF/Text/ImageB]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 2583 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\235\225\225\016\n)-10(\026\220\r\001\025\006)-10(\026\216 \026)11(\025\026)11(\013\007\216\001\025\203 \001\016\025\013\201\230\212\r\013\001\026\001\025\ \203 \026)11(\016\002\013\221\220\220 \r\022\007\016\017\016\001\220\220 \002\013\n\013\ )]TJ 0 -1 TD [(\221\002\205\024\025\203 \n\220\n\220. \033\016\222)21(\215\007\216)21.1(\026)10.9(\013\026\020 \002\013\001\201\025\024\220\222\220\002\025\r\013\001\001\025\ \202)10(\025 \220\006\006)-9.9(\007\016\201\025\r\013\001\220\205)]TJ 39.131 1 Td [(Ef)-31(fectiv)12(eness of th)11(e total neoadju)10.1(v)10(ant th)11(er)21.1(apy in r)31(ectal )]TJ 2.292 -1 Td [(cancer tr)31(eatment. Results of th)11(e r)21(andomiz)10(ed trial)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0.13 Tw 10 0 0 10 42.5197 493.4479 Tm (\030\026\022\024\n \027\017\032\027\036\026\n\023\031\035\016\030\027\024\ \020\024 \024\021\007\036\035\026 \023\030\016\n\024\005 \022\017\001\022\ \017 \023\024)Tj 0 Tw (-)Tj -0.016 Tw 0 -1.218 TD (\f\035\036 \216\214\230 \023\024)Tj /Span<>> BDC ( )Tj EMC (\007\026\027\027\t\n \204\217\230 \r\t\016\r\035\036\027 \n\036\021\026\f\ \021\026 \r)Tj /Span<>> BDC ( )Tj EMC (S7 \023\036\004\036\027\017 )Tj 0.021 Tw T* (\007\024)Tj /Span<>> BDC ( )Tj EMC (1,5)Tj /Span<>> BDC ( )Tj EMC (\f\n \r)Tj /Span<>> BDC ( )Tj EMC (\007\017\026\n\036\021\030\036. \211)Tj /Span<>> BDC ( )Tj EMC (\024\007\027\024\020\024 \023\026\006\017\036\027\021\026 \023\024)Tj /Span<>> BDC ( )Tj EMC (\026\r\036\030\001\036)Tj 0 Tw (-)Tj 0.103 Tw T* (\027\017\017 \216\214\230 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\022\024\027\021\030\024\035\034\027\024\n \025\230 \024\030\020\026\027\ \024\r \020\030\031\007\027\024\005 \022\035\036\021)Tj 0 Tw (-)Tj 0.156 Tw T* (\022\017 \r\t\016\r\035\036\027 \n\036\021\026\f\021\026 \r)Tj /Span<>> BDC ( )Tj EMC (S6 \035\036\r\024\020\024 \035\036\020\022\024\020\024 \007\024)Tj /Span<>> BDC ( )Tj EMC (0,6 \f\n )Tj 0.067 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\007\017\026\n\036\021\030\036, \r)Tj /Span<>> BDC ( )Tj EMC 5.895 0 Td [(\f\r\016\017 )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC [(\004\036\n )0.5(\023\026\006\017\036\027\021\031 )0.5(\002\t\035\024 )0.5(\r\t\023\024\035\027\036\027\024 )]TJ 0.078 Tw -5.895 -1.218 Td (\220\021\026\023\027\024\036 \035\036\004\036\027\017\036. \211)Tj /Span<>> BDC ( )Tj EMC (\007\r\031\b \023\026\006\017\036\027\021\024\r, \022\024\021\024\030\t\n\ \r\t\023\024\035)Tj 0 Tw (-)Tj 0.033 Tw T* (\027\016\035\017 \024\023\036\030\026\021\017\r\027\024\036 \r\n\036\001\ \026\021\036\035\034\f\021\r\024 \017\027\021\030\026\024\023\036\030\026\ \006\017\024\027\027\024 )Tj 0.136 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\023\036\004\036\027\017 \r\t\016\r\035\036\027\t \f\024\035\017\021\026\ \030\027\t\036 \n\036\021\026\f\021\026\t. \200)Tj /Span<>> BDC ( )Tj EMC (\024\002\024\017\b )Tj 0.138 Tw T* (\f\035\031\004\026\016\b \r\t\023\024\035\027\036\027\024 \f\017\n\031\035\ \034\021\026\027\027\024\036 \024\023\036\030\026\021\017\r\027\024\036 \ \r\n\036)Tj 0 Tw (-)Tj 0.135 Tw T* (\001\026\021\036\035\034\f\021\r\024 \f)Tj /Span<>> BDC ( )Tj EMC (\026\021\017\023\017\004\027\024\005 \030\036\036\022\006\017\036\005 \f\ \036\020\n\036\027\021\024\r \023\036\004\036)Tj 0 Tw (-)Tj 0.133 Tw T* (\027\017. \230\026\022\017\n \024\002\030\026\024\n, \023\030\024\020\030\ \036\f\f\017\030\024\r\026\027\017\036 \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \230\203\230 )Tj 0.185 Tw 23.244 13.396 Td (\024\021\n\036\004\036\027\024 \r)Tj /Span<>> BDC ( )Tj EMC (1/60 \(1%\) \f\035\031\004\026\036\r \r)Tj /Span<>> BDC ( )Tj EMC (\f\030\026\r\027\036\027\017\017 \f)Tj /Span<>> BDC ( )Tj EMC (4/71 )Tj 0 Tw T* (\(6%\) \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \216\214\230 \()Tj /T1_2 1 Tf (\032)Tj /T1_1 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,4\).)Tj 0.201 Tw T* [(\215\024\f\035\036 )0.5(\024\022\024\027\004\026\027\017\016 )0.6(\027\036\024\026\007\255\033\r\026\027\021\027\024\020\024 )0.6(\035\036\004\036\027\017\016 )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC 20.255 0 Td (\023\030\024)Tj 0 Tw (-)Tj 0.298 Tw -20.255 -1.218 Td (\b\024\032\007\036\027\017\016 \022\024\027\021\030\024\035\034\027\024\020\ \024 \024\002\f\035\036\007\024\r\026\027\017\016 \031)Tj /Span<>> BDC ( )Tj EMC (18 \017)Tj /Span<>> BDC ( )Tj EMC (60 )Tj 0.164 Tw T* (\(30%\) \023\026\006\017\036\027\021\024\r \017)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\t \230\203\230 \017)Tj /Span<>> BDC ( )Tj EMC (\031 8)Tj /Span<>> BDC ( )Tj EMC (\(11%\) \017)Tj /Span<>> BDC ( )Tj EMC (71 )Tj 0.027 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\t \216\214\230 \r\t\016\r\035\036\027 \023\024\035\027\ \t\005 \022\035\017\027\017\004\036\f\022\017\005 \030\036\020\030\036\f\ \f )Tj -0.041 Tw T* (\024\023\031\b\024\035\017, \r)Tj /Span<>> BDC ( )Tj EMC (\f\r\016\017 \f)Tj /Span<>> BDC ( )Tj EMC (\004\036\n \220\021\017 \023\026\006\017\036\027\021\t \024\021\022\026\ \026\035\017\f\034 \024\021 \b\017)Tj 0 Tw (-)Tj -0.1 Tw T* (\030\031\030\020\017\004\036\f\022\024\020\024 \035\036\004\036\027\017\016\ \r)Tj /Span<>> BDC ( )Tj EMC (\023\024\035\034\031 \007\017\027\026\n\017\004\036\f\022\024\020\024 \027\ \026\002\035\033)Tj 0 Tw (-)Tj 0.097 Tw T* (\007\036\027\017\016 \r)Tj /Span<>> BDC ( )Tj EMC [(\030\026\n\022\026\b \f\021\030\026\021\036\020\017\017 )0.5(\253w)-12(a)15(tch&w)-12(ai)-23.9(t\273 \()]TJ /T1_2 1 Tf 0 Tw (\032)Tj /T1_1 1 Tf 0.097 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,006\). )Tj 0.024 Tw T* (\210\f\021\026\035\034\027\t\n 41)Tj /Span<>> BDC ( )Tj EMC (\(68%\) \017)Tj /Span<>> BDC ( )Tj EMC (60 \002\024\035\034\027\t\b)Tj /Span<>> BDC ( )Tj EMC (\227 \017)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\t \230\203\230 )Tj 0.076 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (63)Tj /Span<>> BDC ( )Tj EMC (\(89%\) \017)Tj /Span<>> BDC ( )Tj EMC (71)Tj /Span<>> BDC ( )Tj EMC (\227 \017)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\t \216\214\230 \002\t\035\024 \r\t\023\024\035\027\036\ \027\024 )Tj 0 Tw T* (\024\023\036\030\026\021\017\r\027\024\036 \r\n\036\001\026\021\036\035\034\ \f\021\r\024 \(\217\017\f.)Tj /Span<>> BDC ( )Tj EMC (2,3\).)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 9 0 0 9 42.5197 730.483 Tm (\020\004\206\f\t\204\004 2.)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf ( \222\n\003\033\023\026\031\021\024\021\n\t\024\022 \025)Tj /Span<>> BDC ( )Tj EMC (\033\031\032\031\021\n\t\025\003\n\t\024\022 \021\031\n\026\030\b\007\027\ \026\021\024\021\n\017 \024\031\032\026\033\025\025)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0 -1.2 TD [(T)48(able 2)16(.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf [( Com)16.1(pliance and tolerability of neoadjuv)16.3(ant therap)12.1(y)]TJ ET 0 0 0 1 K 0.5 w /GS2 gs q 1 0 0 1 42.5197 715.181 cm 0 0 m 219.912 0 l S Q q 1 0 0 1 42.7697 694.3618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 262.4315 715.181 cm 0 0 m 89.348 0 l S Q q 1 0 0 1 262.4315 694.3618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 351.7796 715.181 cm 0 0 m 89.348 0 l S Q q 1 0 0 1 351.7796 694.3618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 441.1278 715.181 cm 0 0 m 54.935 0 l S Q q 1 0 0 1 441.1278 694.3618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 495.813 694.3618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 42.5197 694.1118 cm 0 0 m 219.912 0 l S Q q 1 0 0 1 42.7697 682.8925 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 262.4315 694.1118 cm 0 0 m 89.348 0 l S Q q 1 0 0 1 262.4315 682.8925 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 351.7796 694.1118 cm 0 0 m 89.348 0 l S Q q 1 0 0 1 351.7796 682.8925 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 441.1278 694.1118 cm 0 0 m 54.935 0 l S Q q 1 0 0 1 441.1278 682.8925 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 495.813 682.8925 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 42.5197 682.6425 cm 0 0 m 219.912 0 l S Q q 1 0 0 1 42.7697 671.4313 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 262.4315 682.6425 cm 0 0 m 89.348 0 l S Q q 1 0 0 1 262.4315 671.4313 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 351.7796 682.6425 cm 0 0 m 89.348 0 l S Q q 1 0 0 1 351.7796 671.4313 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 441.1278 682.6425 cm 0 0 m 54.935 0 l S Q q 1 0 0 1 441.1278 671.4313 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 495.813 671.4313 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 671.1813 cm 0 0 m 219.912 0 l S Q q 1 0 0 1 42.7697 640.77 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 262.4315 671.1813 cm 0 0 m 89.348 0 l S Q q 1 0 0 1 262.4315 640.77 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 351.7796 671.1813 cm 0 0 m 89.348 0 l S Q q 1 0 0 1 351.7796 640.77 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 441.1278 671.1813 cm 0 0 m 54.935 0 l S Q q 1 0 0 1 441.1278 640.77 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 495.813 640.77 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 42.5197 640.52 cm 0 0 m 219.912 0 l S Q q 1 0 0 1 42.7697 610.1087 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 262.4315 640.52 cm 0 0 m 89.348 0 l S Q q 1 0 0 1 262.4315 610.1087 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 351.7796 640.52 cm 0 0 m 89.348 0 l S Q q 1 0 0 1 351.7796 610.1087 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 441.1278 640.52 cm 0 0 m 54.935 0 l S Q q 1 0 0 1 441.1278 610.1087 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 495.813 610.1087 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 42.5197 609.8587 cm 0 0 m 219.912 0 l S Q q 1 0 0 1 42.7697 579.4474 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 262.4315 609.8587 cm 0 0 m 89.348 0 l S Q q 1 0 0 1 262.4315 579.4474 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 351.7796 609.8587 cm 0 0 m 89.348 0 l S Q q 1 0 0 1 351.7796 579.4474 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 441.1278 609.8587 cm 0 0 m 54.935 0 l S Q q 1 0 0 1 441.1278 579.4474 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 495.813 579.4474 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 42.5197 579.1974 cm 0 0 m 219.912 0 l S Q q 1 0 0 1 42.7697 558.3861 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 262.4315 579.1974 cm 0 0 m 89.348 0 l S Q q 1 0 0 1 262.4315 558.3861 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 351.7796 579.1974 cm 0 0 m 89.348 0 l S Q q 1 0 0 1 351.7796 558.3861 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 441.1278 579.1974 cm 0 0 m 54.935 0 l S Q q 1 0 0 1 441.1278 558.3861 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 495.813 558.3861 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 42.5197 558.1361 cm 0 0 m 219.912 0 l S Q q 1 0 0 1 42.7697 537.3248 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 262.4315 558.1361 cm 0 0 m 89.348 0 l S Q q 1 0 0 1 262.4315 537.3248 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 351.7796 558.1361 cm 0 0 m 89.348 0 l S Q q 1 0 0 1 351.7796 537.3248 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 441.1278 558.1361 cm 0 0 m 54.935 0 l S Q q 1 0 0 1 441.1278 537.3248 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 495.813 537.3248 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 42.5197 537.0748 cm 0 0 m 219.912 0 l S Q q 1 0 0 1 42.7697 516.2635 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 262.4315 537.0748 cm 0 0 m 89.348 0 l S Q q 1 0 0 1 262.4315 516.2635 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 351.7796 537.0748 cm 0 0 m 89.348 0 l S Q q 1 0 0 1 351.7796 516.2635 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 441.1278 537.0748 cm 0 0 m 54.935 0 l S Q q 1 0 0 1 441.1278 516.2635 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 495.813 516.2635 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 42.5197 516.0135 cm 0 0 m 219.912 0 l S Q q 1 0 0 1 262.4315 516.0135 cm 0 0 m 89.348 0 l S Q q 1 0 0 1 351.7796 516.0135 cm 0 0 m 89.348 0 l S Q q 1 0 0 1 441.1278 516.0135 cm 0 0 m 54.935 0 l S Q BT /GS1 gs /T1_3 1 Tf 8 0 0 8 82.8053 701.7464 Tm (\017\217\002\206\r\b\b\002\217\003\t \b\r\002\004\240\222\211\004\b\003\ \b\002\n\002 \f\r\201\r\b\t\235)Tj 25.656 0.6 Td (\027\006\210\212\212\004 \020\025\020)Tj 0.993 -1.2 Td (N)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (60)Tj 10.164 1.2 Td (\027\006\210\212\212\004 \221\035\020)Tj 1.004 -1.2 Td (N)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (71)Tj /T1_4 1 Tf 10.128 0.6 Td (P)Tj /T1_1 1 Tf -52.596 -2.033 Td (\215\024\035\027\t\005 \022\031\030\f \027\036\024\026\007\255\033\r\026\ \027\021\027\024\020\024 \035\036\004\036\027\017\016)Tj 30.1 0 Td (51/60)Tj /Span<>> BDC ( )Tj EMC (\(85%\))Tj 11.169 0 Td (70/71)Tj /Span<>> BDC ( )Tj EMC (\(99%\))Tj /T1_3 1 Tf 10.33 -0.001 Td (0,006)Tj /T1_1 1 Tf -51.598 -1.433 Td (\215\030\036\030\t\r\026\027\017\036 \035\031\004\036\r\024\005 \021\036\ \030\026\023\017\017)Tj 32.41 0 Td (\226)Tj 9.359 0 Td (1/71)Tj /Span<>> BDC ( )Tj EMC (\(1%\))Tj 10.84 0 Td (1)Tj -52.608 -1.433 Td (\210\002\013\026\016 \004\026\f\021\024\021\026 \035\031\004\036\r\024\005\ \021\024\022\f\017\004\027\024\f\021\017 \023\024)Tj /Span<>> BDC ( )Tj EMC (\001\022\026\035\036 RTOG, )Tj /T1_2 1 Tf (n)Tj /T1_1 1 Tf ( \(%\))Tj T* (Grade 1\2262)Tj T* (Grade 3-4)Tj 30.1 1.2 Td (35/60)Tj /Span<>> BDC ( )Tj EMC (\(58%\))Tj 2.309 -1.2 Td (\226)Tj 8.743 1.2 Td (49/ 71)Tj /Span<>> BDC ( )Tj EMC (\(69%\))Tj 0.616 -1.2 Td (1/71)Tj /Span<>> BDC ( )Tj EMC (\(1%\))Tj 10.497 1.2 Td (0,2)Tj -52.266 -2.633 Td (\210\002\013\026\016 \004\026\f\021\024\021\026 \021\024\022\f\017\004\036\ \f\022\017\b \030\036\026\022\006\017\005 \023\024)Tj /Span<>> BDC ( )Tj EMC (\001\022\026\035\036 NCI-CTC, )Tj /T1_2 1 Tf (n)Tj /T1_1 1 Tf ( \(%\))Tj 0 -1.2 TD (Grade 1\2262)Tj 0 -1.2 TD (Grade 3-4)Tj 30.1 1.2 Td (24/60)Tj /Span<>> BDC ( )Tj EMC (\(40%\))Tj 0.5 -1.2 Td (2/60)Tj /Span<>> BDC ( )Tj EMC (\(3%\))Tj 10.669 1.2 Td (12/71)Tj /Span<>> BDC ( )Tj EMC (\(17%\))Tj 2.309 -1.2 Td (\226)Tj /T1_3 1 Tf 8.02 1.199 Td (0,002)Tj /T1_1 1 Tf -51.598 -2.632 Td (\206\036\n\026\021\024\035\024\020\017\004\036\f\022\026\016 \021\024\022\ \f\017\004\027\024\f\021\034, )Tj /T1_2 1 Tf (n)Tj /T1_1 1 Tf ( \(%\))Tj 0 -1.2 TD (Grade 1\2262)Tj T* (Grade 3\2264)Tj 30.35 1.2 Td (6/60)Tj /Span<>> BDC ( )Tj EMC (\(10%\))Tj 0.25 -1.2 Td (2/60)Tj /Span<>> BDC ( )Tj EMC (\(3%\))Tj 11.169 1.2 Td (1/71)Tj /Span<>> BDC ( )Tj EMC (\(1%\))Tj 1.809 -1.2 Td (\226)Tj /T1_3 1 Tf 8.298 1.199 Td (0,01)Tj /T1_1 1 Tf -51.876 -2.632 Td (\212\017\026\030\036\016, )Tj /T1_2 1 Tf (n)Tj /T1_1 1 Tf ( \(%\))Tj 0 -1.2 TD (Grade 1\2262)Tj 30.1 0 Td (14/60)Tj /Span<>> BDC ( )Tj EMC (\(23%\))Tj 11.169 0 Td (10/71)Tj /Span<>> BDC ( )Tj EMC (\(14%\))Tj 10.997 0 Td (0,2)Tj -52.266 -1.433 Td (\215\036\030\017\235\036\030\017\004\036\f\022\026\016 \023\024\035\017\027\ \036\005\030\024\023\026\021\017\016, )Tj /T1_2 1 Tf (n)Tj /T1_1 1 Tf ( \(%\))Tj T* (Grade 1\2262)Tj 30.6 0 Td (5/60)Tj /Span<>> BDC ( )Tj EMC (\(8%\))Tj 10.669 0 Td (10/71)Tj /Span<>> BDC ( )Tj EMC (\(14%\))Tj 10.997 0 Td (0,4)Tj -52.266 -1.433 Td (\230\024\001\027\024\021\026, )Tj /T1_2 1 Tf (n)Tj /T1_1 1 Tf ( \(%\))Tj T* (Grade 1\2262)Tj 30.6 0 Td (5/60)Tj /Span<>> BDC ( )Tj EMC (\(8%\))Tj 11.169 0 Td (1/71)Tj /Span<>> BDC ( )Tj EMC (\(1%\))Tj 10.497 0 Td (0,1)Tj ET q 42.52 327.623 453.543 -205.027 re W n q /GS0 gs 453.5433589 0 0 206.1049217 42.5197002 121.5183696 cm /Im0 Do Q Q BT 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf -0.033 Tw 9 0 0 9 42.5197 111.7959 Tm (\022\t\217\210\b\002\220 2.)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf ( \213\023\n\013-\t\004\031\003\026 \032\031\016\205\023\022\024\026\024\n\ \027 \021\031\n\026\030\b\007\027\026\021\024\021\n\202\n \023\031\006\031\ \021\025\002 \033\026\203\025\031\021\024\n\027 \027)Tj /Span<>> BDC ( )Tj EMC (\202\032\205\033\033\031 \220\217\220: \213\216\221)Tj /Span<>> BDC ( )Tj EMC (\227 \005\031\016 \033\032\025\016\021\026\013\n\027 \027\n\016\027\032\026\ \024\026 )Tj 0 Tw 0 -1.2 TD (\016\026\005\n\023\031\027\026\021\025\002)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0.043 Tw T* [(F)-16(igure 2)16(.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf [( Flow)11(char)-40(t of the results of neo-adjuv)16.1(ant treatment of patients in the TNT g)14.1(roup: BPVZ)]TJ /Span<>> BDC ( )Tj EMC [(\227 without signs of a retur)-14(n of )]TJ 0 Tw T* (the disease)Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\021\032)50(\b)42(\032\231\027 \213\036)30.1(\005\t\033)30(\b)]TJ 52.896 0 Td (LEADING ARTICLE)Tj /T1_5 1 Tf 25 0 0 25 511.9395 56.0378 Tm (15)Tj ET endstream endobj 2584 0 obj <>stream AdobedC     '$''''$25552;;;;;;;;;;w   S!1"4ATt23QSUau#5BRs$Cbq %&'()*6789:DEFGHIJVWXYZcdefghijrvwxyz?QCf5c5#:ӱ=eȬ}K[Ȭ}K[Ȭ}K[Ȭ}K[Ȭ}K[Ȭ}K[Ȭ}K[Ȭ}K[Ȭ}K[Ȭ}K[Ȭ}K[Ȭ}K[Ȭ}K[v6|Ƕl7 O31VQDܭ~ԵuDE\Ѹ>\ w+DOĥ"""""""""""""""""""""""QDܭ~ԵuDECۥM HƹΏF̪ص:<-%nզ`=)9咳X!8%c>FnJ Ntm ZF FȢ - 61kZр MOtJZ""""""""""""""""""""""" QDܭ~ԵuDE,Xfcd1Unzfw.ގiw*B+Wn:5t`wZi;Ns⛫́OFww(j}LۧRQDܭ~ԵuDQ/iU}Vj J洜;B'X}vvbls#s!WOm䭐WDH%tXl߁/x7kE!ָ2C\Naqhv#ߌVj}LۧRQW޵^Z{OFkf۳JtF ''Gnˏѻ.?~2tF '/ s܌u_ѻ.?~2tF ''Gnˏѻ.?~2tF 汦YdPW$}-nI8"z@V興QFRӫHbjd$c3n$ѭwh$֍^tkF/ :5v}nѻ>vNhݟ[E'FnϭݢZ7gxIѭwh$֍^tkF/ :5v}nѻ>vNhݟ[E'FnϭݢZ7gxIѭwh$֍^tkF/ :5v}nѻ>vNhݟ[E'FnϭݢZ7gxIѭwh$֍^tkF/ :5v}n-:9dx[:?z*^ѻ>vNhݟ[E'FnϭݢZ7gxIѭwh$֍^tkF/ :5v}nѻ>vNhݟ[E'FnϭݢZ7gxIѭwh$֍^tkF/ :5v}nѻ>vNhݟ[E'FnϭݢZ7gxIѭwh$֍^tkF/ :5v}nѻ>vNhݟ[E/zi}I8.͐σJDDDDDDDDDDDDDDQy b1yAm+kX$趕ٵ~t[J? :-vm~һ6uNi]_'EͯcWfK ZVLvKpx㌂w^dlt85sy$m+kX$趕ٵ~t[J? :-vm~һ6uNi]_'EͯcWfIm+kX$趕ٵ~t[J? Qpӭ&iݒK#$d9~玗kǬU5m7aeX[2_һ6uNi]_'EͯcWfIm+kX$趕ٵ~t[J? :-vm~һ6uNi]_/H/RkL6c{^qg׺"""(һ6uNi]_'EͯcWfIm+kX$趕ٵ~8Ij 5ZJ x;ert4u+i]_'EͯcWfIm+kX$趕ٵ~;.,vx#JKCL/lOa`F2F?-ESj[3Y$Z5M oxgq!yViy앭,Z1~vin3XA=T4tQGl7~I p앂H $J]S+h&*jORVXڒj h|erjj4p_,s7 έB>ڳSGs\51xYq#k3Mij6o1v'QYk!|a.1PkM5[j6>Id[-X45s%JV4Mm.R}-lc&22ݖ -+$ݖ -Una`k'LFaCq<:{v.SMf;oL#f%bR N3Jb1ip?E$sM8s3p:ve&L5Fr΋RJͅ2pimwYjv,MʺKV ȫ4%ۇ+#Hmg؊GjT&[ c*609$|_t.fIlrָ]#gI%-Zc`vGԸQCH:펾#Z&7 kZ6؆MG$n}!3'~ӥo0MeIеn+"nisA[hBAv~'=|gK]謳ZWn6G9̕d LKc~մ٢S;7|LS4+]S(ڵ ڕ7`8(ϻqhͧ|S%(+Nw'z""Ko{u-Dս]I!Z/9ish~2Hx/z5YrV-7H]24ǥ=u!z4+iYb .{yߞw8 XĬ/qe?gyw޽#nCgvN6 78^興IVjZZ"""* b7Tj 3΄ nڭJ.86#t3Ҵd h҉[Ĉ1Q N1ΧEѲ8/W6788˜:38AV]PpAf}E㑭1Lwn;N.0b'HZYtPXctN;7筻2EOrRRQJ]S+h oL~bpw[ @9Ĝ9nCN3r\:#FD\"$xdn0AM2)J$k/s/L } u;kDOk\X>:z̵=lS$s:(\9s3^Spp4 0ڙ?!8vF#xIJmWE;lovߺƧ Ӣ6K_H.DX 9 =`UeoSB$~ʍ ^!^1'JZ݌G_x_6xKaW^R.$3ynopMIƱ4H1]RGfrAq[RjUeU.FtYSr'acXvy!~ϯ_ܲv>}xOp=1ǀw5jI9 5[^e$p׳.s K \0̅P쓀nGXQa̹'dll>Ӏ3gx^JLI6 `X3n4;yn3w.Dܭ~ԵuDDDU<toBwղ"M2papvl?djk:4}ydEeV΄, bg7]>7ֿt޶ZzmkWOMi]>7ֿt޶ZzmkWOMkO\KXyĀD\#02ӞKDDDQ5oqW{RriMq s$/d`pss<~;㍑INbO<͒m2FN`'hhLX`b;9JwϽ}Ki{LOBub Q)7.D cv3z^ UcXMCK"~gn0+N. J.o&{1mϹx&=lC!4"q4G-v_Q\R:X{:3t+sc=6 5{atnf}`DWx;sP1=DdIql_#Z37 ރݞ[6#y-mfFͲFçv:hmclM,N*ih s#Xㆀr@޾Η@F.+Nn|?HN9]2U@(,պg$;{J|஄#lFlq2ēO.q5ۑ#j& g*Lz=>-9%G4̉isw$k"""ҩ^OLh V4DƳkYvTIm6+&t׋˦|tq>&I8X8k_}o[^1d5A @Y˸pDx/ k_}o[^5+jkGR&챼dI1I;l #e,DzMhY71VP_Hj[aWAf8Fu^p뼡epkqY[\go7do^vxIf)5dk!g6o 7]75u^6Z-Gbr؀vk=2;o _ZXè1D[c;;bzP2΢Fviu H-$Hѐcn}_^oRu' XkG&9۷`9_K7yr1u+XnѿOMYdܞ6~'9<\x9ǟK]WPYvHs x p0kv85 Hf5۾'X NDQ$+_-|]e- .O:QBպlE!SQDս]I!Z"~Z9\ac>Adkܝ󜯩4*q2J'vi-k01rJKSSF)REJK{_3hcǟlIVjZZ""""""(]zu=QBպlE"SQDս]I! 5{Zԃ .f]#rgy+Z֛6j+I۲ZC3Mwn_19 d)qlߧD٬36$lnk!=eini4jǹNy=xݑsGm֨,뱉k>8,yp9ez-.yWC.Wf|r04m0F]$oM&2#j6gZ UZ\hZeI9Ì~n^xMUn5 8cK9iiγ E]l{p$, tMi3Ey6d$ w@^k#Nl:Yi͂6s0 ޣ3d#ZGȱ#syimwKڱVӗtqhtdg引M'*bWGcl/Cd$q<`=K_YKDDDDDDESΧ"""""""""""""QBպlE"SQDս]I!? 4Q֌fX47{_ʹ%~C'"r $Cۍ6Lr0[~Ϝ* }Vߎ PAhm2 0bwG2n X%׷ս,_L]V8Y6N!ǥͻ|[f؜/ݷ,A [isqޟeyI>t䅓_<lDۗ Z6ْNFOAͤKmt"ș\qYuK:aQaM -:Gv;12$|0qU/|K 1$F4) oux ppwpI8_pz.Ojk3WDWn #iu[Ι?N#cǥ }K['#=-oXNGgzZްga9ϱkzr;=cv{>ǥ }K['#=-oXNGgzZްga9ϱkzr;=cv{>ǥ }K['#=-oXNGgzZްb6̶%̍H" '= HV1w|9DDDDDDDDDDDDD@QBZ:Ϧּγ!9u3jN]k>Z:Ϧּγ!9u3j_sAFƗ=٬p9OS!Z"""""""""(z}'ĕ1DOĥ"""""""""Ko{u-x̿DDDDQD}RH>!Z"""""""""(z}'ĕ1DOĥ"""""""""Ko{u-x̿DDDDQD}RH>!Z"""""""""(z}'ĕ1DOĥ"""""""""Ko{u-x̿DDDDQD}RH>!Z"""""""""(z}'ĕ1DOĥ"""""""""Ko{u-x̿DDDDQD}RH>!Z"""""""""(z}'ĕ1DOĥ"""""""""Ko{u-x̿DDDDQyYkj@K!84e0 (/]NI}IE>礋SysEi<Ϲ"贞gzے֧r\.y52pzP85oYUT5ąnkې\NI}IE>礋SysEi<Ϲ"贞gztZO3zHuJe `.{K$<8HidDP۪{C'{\k^ÚA""_=Mg֓uǩtNX5ZNI:c}i:'[,zϭ'D{ŏSYoxk>xaTAg;#}[m^ѵ@89z֦V`D3VZm8<עuǩtNX5ZNI:c}i:'[,zϭ'D{ŏSYoxk>=Mg֗zi$d JHHg @. 8i=5Ŏd/]NI}IE>礋SysEi<Ϲ"Q‹Z5h5ִUڒ8<8~1V%kCM \YOq /ދI}IE>礋SysEi<Ϲ"贞gz|[H2Cˀ#e방H=ЄM#&Ԍ<5d|ysEi<Ϲ"贞gztZO3zHu:-'=$^/]NI}IE>礋SysE몛F5]V]N)aE ]Kִ|*ysEi<Ϲ"贞gztZO3zHu:-'=$^/]NI}IE>礋Wĺ؂3,wd{-8fKZ ZO!pckdy/̓A/̓A/̓A/̓A/̓A/̓Ak8Eg4hf㑶)xxO꬐QDս]I!Z5;Zȫä2'9瓶sqe!,SCb{]D^G#K= 6)ce vB6 h[0aqvApT5M$lkLQLwu_tyOL`m5 Gg;8ݜJNdY|SI57K"ã>Ipc;8UTۉϑ̎$qFFAoXG.rBYQӴ4ldm{':uFlڹ%8kcgpGzzlٍ,%1 Dۣ+-{MLVM'mgKpqU\աw/k(I"'ڲ83ohEvwULg*&*jA R|p7sx_]aKDDDQ4ΦmhGVjU*Z"|n;Vv8gϑν=[aX"(mWR~UQDս]I!ZEdVifú_ȃ#~l<|F2 &Iv;捶tKwvгɨ |cbȍ7j&HP [ߙբ,؎ȭėhR.0[ w ݻii9iyP Eł;3kma{GF YŨfI`ekgh48`dg7zd[sp]1b'J/;yܤ:pjjl5iϖ%n6-8$cΟ4f.Y^pBؐHd˼V~`.TU,meL&d79^TxHatkV\WtXfۗۏ/y0dޤسlgQsDmḏĴg3y;M3w;Z"(O]5z۰ʕf)D\NE&kE8؛m]as$i&F!XGLmMi͝ cFQָ÷pӟ Y<Ċ]ё \,9 $Y1ݵzg񑸴2- N@.*-}jwn!CU1wLאm><^\+ބ(56ѭa R~sn6PS8j7ZWKX82͓<@l .=aNb Lç91Cc!(u8Ksթ]UGdcZ-#.O:Wڕ, kjF^H8)mfn'o_u]@IN1<Y8"r nۇKhڰk> Ž8ٚ"u6`dlt5NF7mYյpO! -4홞˺Qw2=f&ΦY.V?~f;Yav7O <l.22 #;'ݽX(zmXRM3w;Z".k8!5&j\sӆ+Jյz0ZH, Dz$Yw;w1`( nRt\hL2@ad.0W?a; KlXͶ[QQ=1kvxƐd~""[WhY񺾈TX"4h55FS]shF9ΤZz|msnVյ'XuD:C#/D=1&XFwK^&cU%۶= hyԵRmS2jW)F]4U kgq(]~t{XH5Wn*ggb `seI8ݼ>YE 6䑵 bi׹< uUnޯ8vȡ46Ý$Mƒm:R@z~=WRk֪ܙt;r6neDu:Ptk\VvkԝC8#a'ɶi;k#~5^o2nމvGmY!ddi$+)B-40W5ke8#.ܭU=[aX"(mWPOߧRX _:I&a8# VߥZE`l098ی覹V5M2X"pZHTI60_և@p$ͽxZ+ *k凋ksg~=1#g]KM-e`tO4 gʎw.;O+a-)g""u3nKDEIK CNW䚄BxK %npFFG72}*\Ird嬐c8X>[lIO:7i.; ;Gsp hwj{d qZ[pF^ O|rS. g8driFe)Slf>F1/x8HO]yOi6kr;_tKm9%mIפTh xuxP11 7n^꿄0J]S+hl{yjC_7dzn1/[MlE=I8I$N.,#h9s9^ smVj%O)xIcN:-0JkVo7mρ@6v Y\bmD^&Nʮ27l<ߣK=Z<|es}+Y%WKtN;fn}0/۵ҷvu)<]~6r[D[cv@2w yΓ&sPc:m}653<77V3FjءhdSTI)07 Y),xVK5lb-Qf˜OnŀmJtlњIG2BnKyœC=qMFG8wLe~Gwy V?ܪQDս]I!Z""#ԎOGU+N?mC##9uJM =ZVY!(N[Qs dcxi|x?qic:uZ>ɒ= 2#Zƿ-K R6,8^nYTBlͳ=\&n錓32P 2i-XJ=3[,W,u䎦8*ڔ[#ɌaIF$ن:Ǵmt([Ɩm3> 3?Hjmt7zhXigK4'TϞc+c*]-W>7W +DD\=fHgRҮRFI$eW'dlNH93%4QJ/gd8uE|k~+ƽ1 A,YDݪM<5B9x'hȦ9"c][Eydeͽp UFNjsq.^g%E89ǗI$nnҵ!^ BIfR՞%H/г{K㋍ea&cIŃx<݅lA߾ D7m~RK׋gnB674{Q))쒻mF1r7oRhjt5H>;,F9ќBO\Gj4ǖ\X8GWmr.A ‰mI$Ec142hq̣XUu~Cnօ.0W}0fv6s[|ږJW扐2k<ɑXwNF$۰7=J.XZ5j n\ld8o-d!EkjP ךGII-4.qĞ%x+_Jr: u)͂1 GJ F07/3:)-hc~N˚ ap׭>\!>[V9>n3>X-ٮqZOZrZds6$i;[4D#rQDս]I!ZH1{k@$yrVx'8'z78ϑt5F8FyA-$<|#bnܚA$N3bk_kUgv4gOcd򰱎k36 ߌBGSU#h]f\#ْZݱ$cswsWj6t`wS\]3h8$\lӲ,Ӓ(D&on=s8Q(eXמx'D|ln1<7`JS%Z1\HI<\_ao8y}t4k߈aadm &U-M'U.ԃ/ Efjɝ:Xp66d*S=[ՂuG,2X])\-p:ԧpba)QuH & :7k.B/Xݻ5^:1A^F 1n'y׵n*Vӈd ms,`F[z– køͩ/yEBl4044aH304<>l>HnxJ21ܣ(ٷĹ,"FHG{ohۜ76-*v12I]4gH KN/h4]^lb܎k^ɇX6]H4 #Obܑ<-Ú?d= hngvkR5"L[ݲ3Ϳz(zmXRM3w;v&ny\Pnnž'b3yvɨ^K`EWFm'67/U-7Ju:]x,@9Zw8HX} ̉+6k"'H49D6˃K@ +(ةvMNJ̏ŶV9n[&0m]jbt{#s2l9 h ^†*\W5JBCqy37/&XRUeT\0Z;O'ڞs칏xc7y -+Rlt fai%al21ezZ5j Oi4FkE4cOh$4NσI]q❧U.us ~AiH;+hy |Xxmv;$9{TA[Nɺ4Ş58dv0G\O5*ڵ6ܫ=c8H7p Z"whvۻŅ-D:sʥ"""""[WhY񺾈TX"D,_P*𒆛V!?6l~Kvnwi:XM:0/ckc3?Q'qiX8_AhW*6(t̬b)fqMܖ5i-$<T(xoagdoYֱǵa?I<̩8a3JnRx-,Ԃ~.fl$dev6CniQ$2ԭfɘG)%Ā@3ªufmX`ltllXZ8Ƈɉ{n]2k~? +ETZ""""""ռsOB>*@Qy؁kZBCfqÁiA߽xr+=c:r+=c:r+=c:r+=c:r+=c:r+8c?K[Ȭ}K[Ɣ^y/ۖ6sA?$yאMgrV{>ǥtV{>ǥu=;C[TQkc9ϱk{{Vڰ?{˟q8 Fi%׀6Zó h}hoӬS>aB+C厕̐F߶!dlfxiULm2yそ_n%@ا,Mcm;bRZw/\U-E _a|o^睽(p6Xt}SX,ׅ15Z̴a~ь3j&M=.OlK$&-0-mg#9W}CFucܗ:( $7 z]aKDDDQ]s9qsba$II+:WaWQ)Н+(NU~ t'J*?:v~ һ rN]_GBt¯ܣS:WaWQ)Н+(NU~ t'J*?zNRV/Ƴ833숫Np.ih%2t1ko3=!g\cώCfٙ<5+4N9tlsb 6Ų6qT1Ze7-Y4a$f$!5{Nrr(lK3]#v / #͜xஙzmBԢ)\=mOݢsg5,ix$K1taLn{r oM"C_ev #Zv771 >Sw f7fݘqd#$9tKC 鯎Aҵhڤ͗7.e+ݖg>I9|csHi٥!&am8dd25dOV|@tn9xk:Y-3j0rb0RP'z@Qk\d'=ufA߾ WШܝdu&6=˕XHl?e'֝ڇ͖ӼPZwj6ZkNCSR{Mi]|j~_p{Nx[n1=#nv%y³@QETh~!R"""""ڐ|CTDP$4bI&j[afixx㛼nG[r6s2`%d`N|[-ha&y#;;mAs[[wA 6.v7gxݖ}t/v-/o:lIoXz!Dp{.Gm@b?5XQ֡qB$uKZ5%0'8_O'lk63K<Î{C˶X81ܽ'a; =59OhX|6F:P17e鶪K=B68ŗ9푴@9*KSC,)hN".KD7Wb vO^,6α~0wUjUekFZN*/m ѓ%Vw-6,-ydun_j_.izܑ%o1}m5pp‰s:Қ\E&=1E2$/ì?hx ٬6貴H# >w./7y۹ZtNT#{6-LD0F` kL` F-6/%$"k0&Hbp!۽crnJ1Қy1j@fLQ4)8deoEN te{%# a#OarNKzflhI#̒2H1["*{°DDDDDDDDD@QGffxHE^Wm洑MgN=u9&~YB?S]NIǮ$|ЏSk>hGqZѾoDHǴ!xiz:m+l۲kIFI'%KϚzrMgN=u9&~YB?S]NIǮ$|ЏW,͗٧kv|`'Hi>v-DVҡ3\++쓇uԵ,7J45?~TϫJ҂cXg's4t:-hj:q#'.#'._]*^,u>n(%A7v~fa ARgːҒ1ܑ6VҎ}+vb[0@~O::?&3%!|箣3mb01ϻI\ dZEgKզ[di'lNkd݂ZN6W4N6Dl[ZˋyIsXV~ӟn*s>w`;p{NA*FntQ .$:fckUe/nvNp/YnŊ<.>=/P>jHLsx #|8ڐG>64ͧ:NH6,V-ŬeǙ>G'F>OjwE\Z76,9o[-ž&دP;׏2Γg"whvۻŅ-~u}T+ǤiѱG9=䵒찆!Wjf.%zEoJاmHNǻ5g޼mHF[=+V&yL{%<5?$jC*ͥd̅)av]4s-O6}5 7s˰DRz۵L4IHCC7͞\|V_$m#fKvzcMTyf$̌x7g%9ޔ,pN#fWf* ,o(NZ2w9F%ޠzlӬa|7yh4y&W]y֩#9iŻ:>G6r}$Wtn~{#ӱeԗh}$lQGMŁxs Z@q ڮ.!+vY8YAUCgKpZf8jUcc{nɲ,dly^A߾ QDս]I!Z"oQӵKCYkg :ժs ,6iv30gs窽6_[I-_^Ā- 1rwO_oWZ3bgdG $S+t]kfr9 J@a먶]%MίBuDLlHX $nrm1X :L*WT|L 5F$XD1W}Wcs]y'Jn6M#,-l?C 㬺tELg*MԴtKj䎴M{#4' [J? :-vm~һ6uNi]_'EͯcWfIm+kX$趕ٵ~t[J? :-vm~;s8 7EͯcWfIm+kX%SHhm$Kw⼕m+kX$趕ٵ~t[J? xrtVxslloko8;@V(u瘪>Ē6x9,IׂHdm{ku?b.:nTӼPԺw5SڗNCS*{RS|~Oj];uOةKyN[=t)>ku?b.:nTӼPԺw5SڗNCS*{RS|~Oj];uOةKyN[=t)>ku?b.:nUU]Z fl0;O#9hy8]"""""""""QDս]I!Z"NRD6M887Vicu`LƴE\F붥0K%|k%pn$zQ&এfrث^JTexj:&Z<9a,ޣ^ĭ``| p8P:V^Xbccv&w[^汯y>VHF7i^UqR30&ǞxdW"u3nKDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDD@QE]6P0+LF\\ZIݼgQ Pgӣ:Zt=|;Σ4gFu0{=:3wM3ѝG-Ci_p#:)loMksN yΣ4gFu0{=:3wM3ѝG-CiN>ajLztgQ Pgԭ(L)Xk1K# 78pqSQAнi[NDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDQAнi[NDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDQc6Hd;! MwK|m8{"O/dI"%>^D'ӈ$zqD/[N"^ȓEiK|m8{"O/dI"%>^D'ӈ$zqD/[N"^ȓEjAJ8ioX`)|]?uN@. gO_Ӑ3˧Wt :ryt9<~]?uN@. gO_Ӑ3˧Wt :ryt9<~tdM4iVq.s'%Q?}KQdDDDDDDDQ4qTRj&jA Set$1Ofn2Ƹddd1_һ6uNi]_'EͯcWfIm+kX$趕ٵ~:¦RKiNVee-im7)^Ə6yQ@)YLw%&0$sZ4d v&U-W5` >-J[,t)жV .(mt. Ŝ.&Z@iӢ082б¹lש:==dymIe hq||!"ZOR:vlU0lLjx|P8 >ZKȉ>ʚM),˲azRM> j׎sZ[dxH㓁sathiL۹RҩuMox(.h Ew"')#đO[e#[vVm˚Ʒ%A/K\6qs)4JMQDrՙrTbhZHqfH 2zmڥ-zƱB-5DZ4/./{zB%[1̪ml6L2Z~:\2-Qd''l47^ ;JtE+t{YH9ܯx9ˣ44KVqY͠:ld+$E_ܞՂ{ړCD\ 5Zi=]&7rn~TaGRe]4ƷMG8@ڲ8t 48֐v&հ~kt0%g9pw*ksSӦV/+Ň;P^O]Սb.`gqmc>$SxNIۣq )5lM`d.M3w;Z׽?ߵj=]^d5ƜU%́Ľ<:=}W|MNim g^}dcĜ`iέ_S56Mߊ wF`sg̠ՍB[vo[kJMkMtҗ|Hӵ*!d'0<[7,L2Wc.ke#89MlTZei^lFmpc14o'عDELg*ҩuMox/kA (W5m*ԭY{[^,rgj=,mC|ʼnZq'14.hTlUz]q4 q${[RNKU '4BK3c9|oPOQvή˂{X׶Ba ׎<׼3N 9$BvkQӬOCj[-$ `-k9y“Ch7>3[Ȃ[!i6 7nɱ$g4 p47@V=3߳Vw')h_ITlHEU"|ll% 9ൾN3竽FCM86c{,KA$ /&}'ّsi ώ7uH QC=QMc JRČFֵ.`A p^&nւ-ٯYtN׎^XplZ&U-W5`x9nz5U\6L-N7c*߉:WEHN1b~WV1RݢdIFƏj RdqK[)kI,{`k9H8*ˌ/nzEIB@k5B sNp7/_J IŊx8nԏY(`kܚ][TZZ>cdZK.vdcw'yԴ{:e)Uas$sZ9;yK<_p.$|EbmA%k ۊh9p-p݃2668kXZѸ7}rzgg/V &*jOREa0={$Q=p/:ukb(XF֌4 pz"uxBnW6U 3C$am8sd/./U)꽑_{%8W+OdES^ȯy=^O'S{"JqzdW v=SgSǪlt2M]NVc6}u:[zϮC+{ݏTeo{> v=SgSǪlD!\yˉs.$I'y^ endstream endobj 2585 0 obj <>stream endstream endobj 2582 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.373 Tw 10 0 0 10 70.8661 274.2439 Tm (\030\026\r\017\021\017\036\n \035\031\004\036\r\024\020\024 \220\027\021\ \036\030\024\022\024\035\017\021\026. \210\002\013\026\016 \004\026\f\021\ \024\021\026 )Tj 0.13 Tw 0 -1.218 TD (\024\f\035\024\032\027\036\027\017\005 \035\031\004\036\r\024\005 \021\036\ \030\026\023\017\017 \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\026\b \f\021\026\021\017\f\021\017\004\036)Tj 0 Tw (-)Tj -0.004 Tw T* [(\f\022\017 )0.5(\027\026\004\017\n\024 \027\036 )0.5(\030\026\035\017\004\026\035\026\f\034 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 12.648 0 Td [(\002\t\035\026 )0.5(\024\021\n\036\004\036\027\026 \031)]TJ /Span<>> BDC ( )Tj EMC 7.02 0 Td (35/60 )Tj 0.013 Tw -19.667 -1.218 Td (\(58%\) \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \230\203\230 \023\030\024\021\017\r 50/71 \(70%\ \) \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \216\214\230 )Tj 0 Tw T* (\()Tj /T1_1 1 Tf (\032)Tj /T1_0 1 Tf 0.232 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,2\). \215\024\007\026\r\035\016\033\013\036\036 \002\024\035\034\001\017\ \027\f\021\r\024 51/60 \(85%\) )Tj 0.076 Tw T* (\023\026\006\017\036\027\021\024\r \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \230\203\230 \026\r\036\030\001\017\035\017 \r\ \f\036 3 \022\031\030\f\026 \022\024\027)Tj 0 Tw (-)Tj 0.386 Tw T* (\f\024\035\017\007\017\030\031\033\013\036\005 \b\017\n\017\024\021\036\030\ \026\023\017\017, 7)Tj /Span<>> BDC ( )Tj EMC (\(12%\) \023\026\006\017\036\027\021\024\r )Tj 0.061 Tw T* (\026\r\036\030\001\017\035\017 2 \022\031\030\f\026 \b\017\n\017\024\021\ \036\030\026\023\017\017 \017)Tj /Span<>> BDC ( )Tj EMC (2)Tj /Span<>> BDC ( )Tj EMC (\(3%\) \023\026\006\017\036\027\021\026 )Tj 0.057 Tw T* (\026\r\036\030\001\017\035\017 \021\024\035\034\022\024 \024\007\017\027\ \022\031\030\f. \230\024\035\034\022\024 \r)Tj /Span<>> BDC ( )Tj EMC (\024\007\027\024\n \f\035\031\004\026\036 )Tj 0.159 Tw T* (\b\017\n\017\024\021\036\030\026\023\017\016 \002\t\035\026 \023\030\036\ \022\030\026\013\036\027\026 \023\024)Tj /Span<>> BDC ( )Tj EMC (\023\030\017\004\017\027\036 \030\026\r\017)Tj 0 Tw (-)Tj 0.104 Tw T* (\021\017\016 \021\024\022\f\017\004\036\f\022\017\b \030\036\026\022\006\ \017\005. \200)Tj /Span<>> BDC ( )Tj EMC (\024\f\021\026\035\034\027\t\b \f\035\031\004\026\016\b \023\030\017)Tj 0 Tw (-)Tj 0.048 Tw T* [(\004\017\027\024\005 \002\t\035\024 \027\036\f\024\002\035\033\007\036\027\ \017\036 )0.5(\023\030\024\021\024\022\024\035\026 \017\f\f\035\036\007\024\r\026\027\017\ \016. )]TJ 0.067 Tw T* (\210\002\013\026\016 \004\026\f\021\024\021\026 \024\f\035\024\032\027\036\ \027\017\005 \b\017\n\017\024\021\036\030\026\023\017\017 \f\024\f\021\026\ \r\017\035\026 )Tj -0.02 Tw T* (26/60 \(43%\) \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \230\203\230 \023\030\024\021\017\r 12/71 \(17%\ \) \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023)Tj 0 Tw (-)Tj 0.121 Tw T* [(\023\036 \216\214\230, )0.5(\030\026\035\017\004\017\016 \023\030\017)]TJ /Span<>> BDC ( )Tj EMC 9.458 0 Td [(\220\021\024\n \024\022\026\026\035\017\f\034 )0.5(\f\021\026\021\017\f\021\017\004\036\f\022\017 )]TJ -0.006 Tw -9.458 -1.218 Td (\027\026\004\017\n\t \()Tj /T1_1 1 Tf 0 Tw (p)Tj /T1_0 1 Tf -0.006 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,003\) \017)Tj /Span<>> BDC ( )Tj EMC (\002\t\035\017 \024\002\031\f\035\024\r\035\036\027\t \021\024\022\f\017\ \004\036\f\022\017)Tj 0 Tw (-)Tj 0.018 Tw T* (\n\017 \030\036\026\022\006\017\016\n\017 \035\036\020\022\024\005 \f\021\ \036\023\036\027\017 \023\024)Tj /Span<>> BDC ( )Tj EMC [(\001\022\026\035\036 NCI-CT)35(C v5.0. )]TJ -0.008 Tw 23.244 19.485 Td [(\230\016\032\036\035\t\036 )0.6(\021\024\022\f\017\004\036\f\022\017\036 )0.5(\030\036\026\022\006\017\017 )0.6(3\2264)]TJ /Span<>> BDC ( )Tj EMC 14.623 0 Td [(\f\021\036\023\036\027\017 )0.6(\024\021\n\036\004\036\027\t )]TJ 0.134 Tw -14.623 -1.218 Td (\021\024\035\034\022\024 \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \230\203\230 \031)Tj /Span<>> BDC ( )Tj EMC (\007\r\031\b \023\026\006\017\036\027\021\024\r \(3%\) \017)Tj /Span<>> BDC ( )Tj EMC (\002\t\035\017 )Tj -0.021 Tw T* [(\024\002\031\f\035\024\r\035\036\027\t \020\036\n\026\021\024\035\024\020\ \017\004\036\f\022\024\005 )0.5(\021\024\022\f\017\004\027\024\f\021\034\033. )0.5(\215\024)]TJ /Span<>> BDC ( )Tj EMC (\004\026)Tj 0 Tw (-)Tj 0.162 Tw T* (\f\021\024\021\036 \030\026\r\017\021\017\016 \007\017\026\030\036\017,\ \021\024\001\027\024\021\t \017)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\017\235\036\030\017\004\036\f\022\024\005 )Tj 0.254 Tw T* (\023\024\035\017\027\036\005\030\024\023\026\021\017\017 \f\021\026\021\017\ \f\021\017\004\036\f\022\017 \027\026\004\017\n\t\b \030\026\035\017\004\ \017\005 )Tj 0 Tw T* (\023\024\035\031\004\036\027\024 \027\036 \002\t\035\024 \(\230\026\002\035\ .)Tj /Span<>> BDC ( )Tj EMC (2\).)Tj /T1_1 1 Tf 0 -2.436 TD (\230\f\f\031\013\024\025\027\021\n\t\024\022 \021\031\n\026\030\b\007\027\ \026\021\024\021\n\017 \024\031\032\026\033\025\025)Tj /T1_0 1 Tf 0.574 Tw 0 -1.218 TD [(\200\f\036\020\024 \024\021\n\036\004\036\027\024 \023\016\021\034 )0.5(\f\035\031\004\026\036\r \023\030\024\020\030\036\f\f\017\030\024\r\026\027\ \017\016 )]TJ 0.458 Tw T* (\r\024 \r\030\036\n\016 \023\030\024\r\036\007\036\027\017\016 \027\036\024\ \026\007\255\033\r\026\027\021\027\024\020\024 \035\036\004\036\027\017\016\ . )Tj 0.346 Tw T* (\200)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \230\203\230 \031)Tj /Span<>> BDC ( )Tj EMC (1/60 \(2%\) \023\026\006\017\036\027\021\026 \f)Tj /Span<>> BDC ( )Tj EMC (\024\023\031\b\024\035\034\033 )Tj 0.395 Tw T* [(\027\017\032\027\036\026\n\023\031\035\016\030\027\024\020\024 )0.6(\024\021\007\036\035\026 )0.6(\023\024)]TJ /Span<>> BDC ( )Tj EMC 13.638 0 Td [(\024\022\024\027\004\026\027\017\017 )0.6(\230\203\230 )0.5(\024\021)]TJ 0 Tw (-)Tj 0.203 Tw -13.638 -1.218 Td [(\n\036\004\036\027 )0.5(\023\024\035\027\t\005 )0.6(\030\036\020\030\036\f\f )0.5(\023\036\030\r\017\004\027\024\005 )0.5(\024\023\031\b\024\035\017, )0.6(\024\007\027\026\022\024, )]TJ 0.036 Tw T* (\023\024)Tj /Span<>> BDC ( )Tj EMC (\007\026\027\027\t\n \025\230, \r\t\016\r\035\036\027\024 \n\027\024\032\ \036\f\021\r\036\027\027\024\036 \002\017\035\024\002\026\030\027\024\036\ )Tj 0.322 Tw T* (\n\036\021\026\f\021\026\021\017\004\036\f\022\024\036 \023\024\030\026\032\ \036\027\017\036 \035\036\020\022\017\b. \200)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \216\214\230 )Tj 0.096 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (4/71 \(6%\) \027\026\002\035\033\007\036\027\017\016\b \r\t\016\r\035\036\ \027\024 \023\030\024\020\030\036\f\f\017\030\024\r\026)Tj 0 Tw (-)Tj 0.159 Tw T* (\027\017\036. \211)Tj /Span<>> BDC ( )Tj EMC (\024\007\027\024\020\024 \023\026\006\017\036\027\021\026 \f)Tj /Span<>> BDC ( )Tj EMC (\n\036\f\021\027\024\030\026\f\023\030\024\f\021\030\026\027\036\027\027\ \t\n )Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0 Tw 9 0 0 9 70.8661 730.483 Tm (\020\004\206\f\t\204\004 1.)Tj 0 0 0 1 k /GS1 gs /T1_1 1 Tf ( \206\026\032\026\013\024\031\032\025\t\024\025\013\026 \033\026\203\025\ \031\021\024\n\027)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0 -1.2 TD [(T)48(able 1)47(.)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf [( Character)-36.9(istics of patients)]TJ ET 0 0 0 1 K 0.5 w /GS2 gs q 1 0 0 1 70.8661 715.181 cm 0 0 m 227.022 0 l S Q q 1 0 0 1 71.1161 694.3618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 297.8878 715.181 cm 0 0 m 87.874 0 l S Q q 1 0 0 1 297.8878 694.3618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 385.7618 715.181 cm 0 0 m 87.874 0 l S Q q 1 0 0 1 385.7618 694.3618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 473.6358 715.181 cm 0 0 m 51.274 0 l S Q q 1 0 0 1 473.6358 694.3618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 524.6594 694.3618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 70.8661 694.1118 cm 0 0 m 227.022 0 l S Q q 1 0 0 1 71.1161 682.9005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 297.8878 694.1118 cm 0 0 m 87.874 0 l S Q q 1 0 0 1 297.8878 682.9005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 385.7618 694.1118 cm 0 0 m 87.874 0 l S Q q 1 0 0 1 385.7618 682.9005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 473.6358 694.1118 cm 0 0 m 51.274 0 l S Q q 1 0 0 1 473.6358 682.9005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 682.9005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 682.6505 cm 0 0 m 227.022 0 l S Q q 1 0 0 1 71.1161 652.2392 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 297.8878 682.6505 cm 0 0 m 87.874 0 l S Q q 1 0 0 1 297.8878 652.2392 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 385.7618 682.6505 cm 0 0 m 87.874 0 l S Q q 1 0 0 1 385.7618 652.2392 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 473.6358 682.6505 cm 0 0 m 51.274 0 l S Q q 1 0 0 1 473.6358 652.2392 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 524.6594 652.2392 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 70.8661 651.9892 cm 0 0 m 227.022 0 l S Q q 1 0 0 1 71.1161 640.7779 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 297.8878 651.9892 cm 0 0 m 87.874 0 l S Q q 1 0 0 1 297.8878 640.7779 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 385.7618 651.9892 cm 0 0 m 87.874 0 l S Q q 1 0 0 1 385.7618 640.7779 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 473.6358 651.9892 cm 0 0 m 51.274 0 l S Q q 1 0 0 1 473.6358 640.7779 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 640.7779 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 640.5279 cm 0 0 m 227.022 0 l S Q q 1 0 0 1 71.1161 581.3167 cm 0 0 m 0 58.961 l S Q q 1 0 0 1 297.8878 640.5279 cm 0 0 m 87.874 0 l S Q q 1 0 0 1 297.8878 581.3167 cm 0 0 m 0 58.961 l S Q q 1 0 0 1 385.7618 640.5279 cm 0 0 m 87.874 0 l S Q q 1 0 0 1 385.7618 581.3167 cm 0 0 m 0 58.961 l S Q q 1 0 0 1 473.6358 640.5279 cm 0 0 m 51.274 0 l S Q q 1 0 0 1 473.6358 581.3167 cm 0 0 m 0 58.961 l S Q q 1 0 0 1 524.6594 581.3167 cm 0 0 m 0 58.961 l S Q q 1 0 0 1 70.8661 581.0667 cm 0 0 m 227.022 0 l S Q q 1 0 0 1 71.1161 569.8553 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 297.8878 581.0667 cm 0 0 m 87.874 0 l S Q q 1 0 0 1 297.8878 569.8553 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 385.7618 581.0667 cm 0 0 m 87.874 0 l S Q q 1 0 0 1 385.7618 569.8553 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 473.6358 581.0667 cm 0 0 m 51.274 0 l S Q q 1 0 0 1 473.6358 569.8553 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 569.8553 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 569.6053 cm 0 0 m 227.022 0 l S Q q 1 0 0 1 71.1161 558.394 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 297.8878 569.6053 cm 0 0 m 87.874 0 l S Q q 1 0 0 1 297.8878 558.394 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 385.7618 569.6053 cm 0 0 m 87.874 0 l S Q q 1 0 0 1 385.7618 558.394 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 473.6358 569.6053 cm 0 0 m 51.274 0 l S Q q 1 0 0 1 473.6358 558.394 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 558.394 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 558.144 cm 0 0 m 227.022 0 l S Q q 1 0 0 1 71.1161 508.5328 cm 0 0 m 0 49.361 l S Q q 1 0 0 1 297.8878 558.144 cm 0 0 m 87.874 0 l S Q q 1 0 0 1 297.8878 508.5328 cm 0 0 m 0 49.361 l S Q q 1 0 0 1 385.7618 558.144 cm 0 0 m 87.874 0 l S Q q 1 0 0 1 385.7618 508.5328 cm 0 0 m 0 49.361 l S Q q 1 0 0 1 473.6358 558.144 cm 0 0 m 51.274 0 l S Q q 1 0 0 1 473.6358 508.5328 cm 0 0 m 0 49.361 l S Q q 1 0 0 1 524.6594 508.5328 cm 0 0 m 0 49.361 l S Q q 1 0 0 1 70.8661 508.2828 cm 0 0 m 227.022 0 l S Q q 1 0 0 1 71.1161 468.2715 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 297.8878 508.2828 cm 0 0 m 87.874 0 l S Q q 1 0 0 1 297.8878 468.2715 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 385.7618 508.2828 cm 0 0 m 87.874 0 l S Q q 1 0 0 1 385.7618 468.2715 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 473.6358 508.2828 cm 0 0 m 51.274 0 l S Q q 1 0 0 1 473.6358 468.2715 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 524.6594 468.2715 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 70.8661 468.0215 cm 0 0 m 227.022 0 l S Q q 1 0 0 1 71.1161 428.0102 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 297.8878 468.0215 cm 0 0 m 87.874 0 l S Q q 1 0 0 1 297.8878 428.0102 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 385.7618 468.0215 cm 0 0 m 87.874 0 l S Q q 1 0 0 1 385.7618 428.0102 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 473.6358 468.0215 cm 0 0 m 51.274 0 l S Q q 1 0 0 1 473.6358 428.0102 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 524.6594 428.0102 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 70.8661 427.7602 cm 0 0 m 227.022 0 l S Q q 1 0 0 1 71.1161 387.7489 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 297.8878 427.7602 cm 0 0 m 87.874 0 l S Q q 1 0 0 1 297.8878 387.7489 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 385.7618 427.7602 cm 0 0 m 87.874 0 l S Q q 1 0 0 1 385.7618 387.7489 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 473.6358 427.7602 cm 0 0 m 51.274 0 l S Q q 1 0 0 1 473.6358 387.7489 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 524.6594 387.7489 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 70.8661 387.4989 cm 0 0 m 227.022 0 l S Q q 1 0 0 1 71.1161 337.8876 cm 0 0 m 0 49.361 l S Q q 1 0 0 1 297.8878 387.4989 cm 0 0 m 87.874 0 l S Q q 1 0 0 1 297.8878 337.8876 cm 0 0 m 0 49.361 l S Q q 1 0 0 1 385.7618 387.4989 cm 0 0 m 87.874 0 l S Q q 1 0 0 1 385.7618 337.8876 cm 0 0 m 0 49.361 l S Q q 1 0 0 1 473.6358 387.4989 cm 0 0 m 51.274 0 l S Q q 1 0 0 1 473.6358 337.8876 cm 0 0 m 0 49.361 l S Q q 1 0 0 1 524.6594 337.8876 cm 0 0 m 0 49.361 l S Q q 1 0 0 1 70.8661 337.6376 cm 0 0 m 227.022 0 l S Q q 1 0 0 1 71.1161 326.4264 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 297.8878 337.6376 cm 0 0 m 87.874 0 l S Q q 1 0 0 1 297.8878 326.4264 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 385.7618 337.6376 cm 0 0 m 87.874 0 l S Q q 1 0 0 1 385.7618 326.4264 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 473.6358 337.6376 cm 0 0 m 51.274 0 l S Q q 1 0 0 1 473.6358 326.4264 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 326.4264 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 326.1764 cm 0 0 m 227.022 0 l S Q q 1 0 0 1 71.1161 314.9651 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 297.8878 326.1764 cm 0 0 m 87.874 0 l S Q q 1 0 0 1 297.8878 314.9651 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 385.7618 326.1764 cm 0 0 m 87.874 0 l S Q q 1 0 0 1 385.7618 314.9651 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 473.6358 326.1764 cm 0 0 m 51.274 0 l S Q q 1 0 0 1 473.6358 314.9651 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 314.9651 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 314.7151 cm 0 0 m 227.022 0 l S Q q 1 0 0 1 71.1161 303.5038 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 297.8878 314.7151 cm 0 0 m 87.874 0 l S Q q 1 0 0 1 297.8878 303.5038 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 385.7618 314.7151 cm 0 0 m 87.874 0 l S Q q 1 0 0 1 385.7618 303.5038 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 473.6358 314.7151 cm 0 0 m 51.274 0 l S Q q 1 0 0 1 473.6358 303.5038 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 303.5038 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 303.2538 cm 0 0 m 227.022 0 l S Q q 1 0 0 1 297.8878 303.2538 cm 0 0 m 87.874 0 l S Q q 1 0 0 1 385.7618 303.2538 cm 0 0 m 87.874 0 l S Q q 1 0 0 1 473.6358 303.2538 cm 0 0 m 51.274 0 l S Q BT /GS1 gs /T1_2 1 Tf 8 0 0 8 166.3022 701.7463 Tm (\200\032\022\032\215\036\020\022)Tj 19.559 0.6 Td (\027\006\210\212\212\004 \020\025\020)Tj -0.54 -1.2 Td (N)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (60 \(46%\))Tj 11.513 1.2 Td (\027\006\210\212\212\004 \221\035\020)Tj -0.528 -1.2 Td (N)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (71 \(54%\))Tj /T1_3 1 Tf 11.34 0.6 Td (\021)Tj /T1_0 1 Tf -52.887 -2.033 Td (\200\024\030\026\f\021, Me \(Q1, Q3\))Tj 31.289 0 Td (64)Tj /Span<>> BDC ( )Tj EMC (\(52, 68\))Tj 10.984 0 Td (64)Tj /Span<>> BDC ( )Tj EMC (\(57, 71\))Tj 10.284 0 Td (0,3)Tj -52.557 -1.433 Td (\215\024\035, )Tj /T1_1 1 Tf (n)Tj /T1_0 1 Tf ( \(%\))Tj T* (\032\036\027\f\022\017\005)Tj 0 -1.2 TD (\n\031\032\f\022\024\005)Tj 31.618 1.2 Td (25)Tj /Span<>> BDC ( )Tj EMC (\(42%\))Tj T* (35)Tj /Span<>> BDC ( )Tj EMC (\(58%\))Tj 10.984 1.2 Td (25)Tj /Span<>> BDC ( )Tj EMC (\(35%\))Tj T* (46)Tj /Span<>> BDC ( )Tj EMC (\(65%\))Tj 9.955 2.4 Td (0,5)Tj -52.557 -3.833 Td (\222\204\230, Me \(Q1, Q3\))Tj 31.289 0 Td (26)Tj /Span<>> BDC ( )Tj EMC (\(23, 27\))Tj 10.984 0 Td (26)Tj /Span<>> BDC ( )Tj EMC (\(23, 28\))Tj 10.284 0 Td (0,8)Tj -52.557 -1.433 Td (ASA, )Tj /T1_1 1 Tf (n)Tj /T1_0 1 Tf ( \(%\))Tj 0 -1.2 TD (ASAI)Tj 0 -1.2 TD (ASAII)Tj 0 -1.2 TD (ASAIII)Tj 0 -1.2 TD (ASA IV)Tj 0 -1.2 TD (\027\036\017\r\036\f\021\027\024)Tj 31.868 4.8 Td (7)Tj /Span<>> BDC ( )Tj EMC (\(16%\))Tj -0.25 -1.2 Td (32)Tj /Span<>> BDC ( )Tj EMC (\(73%\))Tj 0.25 -1.2 Td (5)Tj /Span<>> BDC ( )Tj EMC (\(11%\))Tj 0.25 -1.2 Td (0)Tj /Span<>> BDC ( )Tj EMC (\(0%\))Tj 0.866 -1.2 Td (16)Tj 9.868 4.8 Td (6)Tj /Span<>> BDC ( )Tj EMC (\(10%\))Tj -0.25 -1.2 Td (39)Tj /Span<>> BDC ( )Tj EMC (\(66%\))Tj T* (13)Tj /Span<>> BDC ( )Tj EMC (\(22%\))Tj 0.5 -1.2 Td (1)Tj /Span<>> BDC ( )Tj EMC (\(2%\))Tj 0.866 -1.2 Td (12)Tj 8.589 6 Td (0,6)Tj -52.557 -7.433 Td (\210\023\036\030\026\006\017\017 \027\026)Tj /Span<>> BDC ( )Tj EMC (\024\030\020\026\027\026\b \002\030\033\001\027\024\005 \023\024\035\024\ \f\021\017 \r)Tj /Span<>> BDC ( )Tj EMC (\026\027\026\n\027\036\036, )Tj /T1_1 1 Tf (n)Tj /T1_0 1 Tf ( \(%\))Tj 32.118 0 Td (4)Tj /Span<>> BDC ( )Tj EMC (\(7%\))Tj 10.484 0 Td (10)Tj /Span<>> BDC ( )Tj EMC (\(14%\))Tj 9.955 0 Td (0,3)Tj -52.557 -1.433 Td (\221\026\b\026\030\027\t\005 \007\017\026\002\036\021, )Tj /T1_1 1 Tf (n)Tj /T1_0 1 Tf ( \(%\))Tj 31.868 0 Td (6)Tj /Span<>> BDC ( )Tj EMC (\(10%\))Tj 11.234 0 Td (6)Tj /Span<>> BDC ( )Tj EMC (\(9%\))Tj 9.205 0 Td (0,76)Tj -52.307 -1.433 Td (\211\030\024\r\036\027\034 \024\027\022\024\n\026\030\022\036\030\024\r,\ Me \(Q1, Q3\))Tj T* (\217\224\202, \027\020/\n\035)Tj 0 -1.2 TD (\027\036\017\r\036\f\021\027\024)Tj 0 -1.2 TD (\221\224\202 19-9, \213\007/\n\035)Tj 0 -1.2 TD (\027\036\017\r\036\f\021\027\024)Tj 31.011 3.6 Td (4,4)Tj /Span<>> BDC ( )Tj EMC (\(2,4, 4,9\))Tj 1.973 -1.2 Td (33)Tj -1.195 -1.2 Td (4)Tj /Span<>> BDC ( )Tj EMC (\(0, 16\))Tj 1.195 -1.2 Td (33)Tj 9.011 3.6 Td (3,2)Tj /Span<>> BDC ( )Tj EMC (\(2,5, 5,4\))Tj 1.973 -1.2 Td (44)Tj -0.945 -1.2 Td (6)Tj /Span<>> BDC ( )Tj EMC (\(1, 7\))Tj 0.945 -1.2 Td (44)Tj 8.589 4.8 Td (0,9)Tj 0 -1.2 TD (0,8)Tj -52.557 -5.033 Td (cT \f\021\026\007\017\016, )Tj /T1_1 1 Tf (n)Tj /T1_0 1 Tf ( \(%\))Tj 0 -1.2 TD (cT2)Tj 0 -1.2 TD (cT3)Tj 0 -1.2 TD (cT4)Tj 31.618 2.4 Td (18)Tj /Span<>> BDC ( )Tj EMC (\(30%\))Tj 0 -1.2 TD (27)Tj /Span<>> BDC ( )Tj EMC (\(45%\))Tj 0 -1.2 TD (15)Tj /Span<>> BDC ( )Tj EMC (\(25%\))Tj 10.984 2.4 Td (15)Tj /Span<>> BDC ( )Tj EMC (\(21%\))Tj 0 -1.2 TD (35)Tj /Span<>> BDC ( )Tj EMC (\(49%\))Tj 0 -1.2 TD (21)Tj /Span<>> BDC ( )Tj EMC (\(30%\))Tj 9.955 3.6 Td (0,3)Tj -52.557 -5.033 Td (cN \f\021\026\007\017\016, )Tj /T1_1 1 Tf (n)Tj /T1_0 1 Tf ( \(%\))Tj 0 -1.2 TD (cN0)Tj T* (cN1)Tj 0 -1.2 TD (cN2)Tj 31.618 2.4 Td (24)Tj /Span<>> BDC ( )Tj EMC (\(40%\))Tj 0 -1.2 TD (17)Tj /Span<>> BDC ( )Tj EMC (\(28%\))Tj 0 -1.2 TD (19)Tj /Span<>> BDC ( )Tj EMC (\(32%\))Tj 10.984 2.4 Td (19)Tj /Span<>> BDC ( )Tj EMC (\(27%\))Tj 0 -1.2 TD (25)Tj /Span<>> BDC ( )Tj EMC (\(35%\))Tj 0 -1.2 TD (27)Tj /Span<>> BDC ( )Tj EMC (\(38%\))Tj 9.955 3.6 Td (0,2)Tj -52.557 -5.033 Td (cTNM, )Tj /T1_1 1 Tf (n)Tj /T1_0 1 Tf ( \(%\))Tj 0 -1.2 TD (I)Tj T* (II)Tj T* (III)Tj 31.618 2.4 Td (12)Tj /Span<>> BDC ( )Tj EMC (\(20%\))Tj T* (12)Tj /Span<>> BDC ( )Tj EMC (\(20%\))Tj T* (32)Tj /Span<>> BDC ( )Tj EMC (\(60%\))Tj 11.234 2.4 Td (9)Tj /Span<>> BDC ( )Tj EMC (\(12%\))Tj -0.25 -1.2 Td (10)Tj /Span<>> BDC ( )Tj EMC (\(15%\))Tj T* (52)Tj /Span<>> BDC ( )Tj EMC (\(73%\))Tj 9.955 3.6 Td (0,3)Tj -52.557 -5.033 Td (\212\017\235\235\036\030\036\027\006\017\030\024\r\022\026 \024\023\031\b\ \024\035\017, )Tj /T1_1 1 Tf (n)Tj /T1_0 1 Tf ( \(%\))Tj 0 -1.2 TD (G1)Tj 0 -1.2 TD (G2)Tj 0 -1.2 TD (G3)Tj 0 -1.2 TD (G4)Tj 31.618 3.6 Td (14)Tj /Span<>> BDC ( )Tj EMC (\(23%\))Tj T* (39)Tj /Span<>> BDC ( )Tj EMC (\(65%\))Tj 0.5 -1.2 Td (5)Tj /Span<>> BDC ( )Tj EMC (\(8%\))Tj T* (2)Tj /Span<>> BDC ( )Tj EMC (\(4%\))Tj 10.484 3.6 Td (16)Tj /Span<>> BDC ( )Tj EMC (\(22%\))Tj T* (48)Tj /Span<>> BDC ( )Tj EMC (\(68%\))Tj 0.5 -1.2 Td (5)Tj /Span<>> BDC ( )Tj EMC (\(7%\))Tj T* (2)Tj /Span<>> BDC ( )Tj EMC (\(3%\))Tj 9.455 4.8 Td (0,8)Tj -52.557 -6.233 Td (CRM)Tj /Span<>> BDC ( )Tj EMC (+)Tj /Span<>> BDC ( )Tj EMC (\023\024 \007\026\027\027\t\n \204\217\230, )Tj /T1_1 1 Tf (n)Tj /T1_0 1 Tf ( \(%\))Tj 31.618 0 Td (25)Tj /Span<>> BDC ( )Tj EMC (\(42%\))Tj 10.984 0 Td (38)Tj /Span<>> BDC ( )Tj EMC (\(54%\))Tj 9.955 0 Td (0,2)Tj -52.557 -1.433 Td (\200\t\f\024\021\026 \024\023\031\b\024\035\017 \024\021 \022\030\026\016\ \026\027\031\f\026 \(\n\n\), Me \(Q1, Q3\))Tj 31.289 0 Td (51)Tj /Span<>> BDC ( )Tj EMC (\(28, 62\))Tj 10.984 0 Td (54)Tj /Span<>> BDC ( )Tj EMC (\(37, 65\))Tj 10.284 0 Td (0,3)Tj -52.557 -1.433 Td (\215\030\024\021\016\032\036\027\027\024\f\021\034 \024\023\031\b\024\035\ \017 \(\n\n\), Me \(Q1, Q3\))Tj 31.289 0 Td (46)Tj /Span<>> BDC ( )Tj EMC (\(39, 61\))Tj 10.984 0 Td (48)Tj /Span<>> BDC ( )Tj EMC (\(40, 56\))Tj 10.284 0 Td (0,9)Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\021\032)50(\b)42(\032\231\027 \213\036)30.1(\005\t\033)30(\b)]TJ 52.896 0 Td (LEADING ARTICLE)Tj -52.896 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 23, \023\0221)69(, 202)69(4)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 23, \023\0221)69(, 202)69(4)]TJ /T1_5 1 Tf 25 0 0 25 27.3527 56.0378 Tm (14)Tj ET endstream endobj 2580 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\235\225\225\016\n)-10(\026\220\r\001\025\006)-10(\026\216 \026)11(\025\026)11(\013\007\216\001\025\203 \001\016\025\013\201\230\212\r\013\001\026\001\025\ \203 \026)11(\016\002\013\221\220\220 \r\022\007\016\017\016\001\220\220 \002\013\n\013\ )]TJ 0 -1 TD [(\221\002\205\024\025\203 \n\220\n\220. \033\016\222)21(\215\007\216)21.1(\026)10.9(\013\026\020 \002\013\001\201\025\024\220\222\220\002\025\r\013\001\001\025\ \202)10(\025 \220\006\006)-9.9(\007\016\201\025\r\013\001\220\205)]TJ 39.131 1 Td [(Ef)-31(fectiv)12(eness of th)11(e total neoadju)10.1(v)10(ant th)11(er)21.1(apy in r)31(ectal )]TJ 2.292 -1 Td [(cancer tr)31(eatment. Results of th)11(e r)21(andomiz)10(ed trial)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0.822 Tw 10 0 0 10 42.5197 724.8299 Tm (\023\036\030\036\n\036\027\027\t\036 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\027\036\027\024\030\n\026\035\034\027\024\n \030\026\f\023\030\036\007\036\ \035\036\027\017\017 )Tj 0.254 Tw 0 -1.218 TD (\r\026\030\017\026\006\017\024\027\027\t\b \030\016\007\024\r \024\023\017\ \f\t\r\026\035\017 \f)Tj /Span<>> BDC ( )Tj EMC (\023\024\n\024\013\034\033 \n\036\007\017)Tj 0 Tw (-)Tj 0.322 Tw T* (\026\027 \017)Tj /Span<>> BDC ( )Tj EMC (\022\r\026\030\021\017\035\036\005 \(Q1, Q3\). \212\035\016 \026\027\026\ \035\017\026 \007\017\b\024\021\024\n\017)Tj 0 Tw (-)Tj 0.417 Tw T* (\004\036\f\022\017\b \023\036\030\036\n\036\027\027\t\b \023\030\017\n\036\ \027\016\035\017 \022\030\017\021\036\030\017\005 \205\017\001\036\030\026\ )Tj 0.166 Tw T* (\017\035\017 \007\017\f\023\036\030\f\017\024\027\027\t\005 \026\027\026\ \035\017 \027\026)Tj /Span<>> BDC ( )Tj EMC (\024\f\027\024\r\036 \022\030\017\021\036\030\017\016 \233)Tj 0 Tw 5.83 0 0 5.83 257.7472 679.4479 Tm (2)Tj 10 0 0 10 260.6622 676.1179 Tm (. )Tj -0.002 Tw -21.814 -1.218 Td (\203\036\023\030\036\030\t\r\027\t\036 \007\026\027\027\t\036 \023\030\017\ )Tj /Span<>> BDC ( )Tj EMC (\f\030\026\r\027\036\027\017\017 \007\r\031\b \020\030\031\023\023 \024\006\ \036)Tj 0 Tw (-)Tj 0.109 Tw T* (\027\017\r\026\035\017 \f)Tj /Span<>> BDC ( )Tj EMC (\023\024\n\024\013\034\033 \021\036\f\021\026 \211\017\035\022\024\022\f\ \024\027\026. \221\021\026\021\017\f\021\017\004\036\f\022\017 )Tj 0.619 Tw 0 -1.218 TD [(\027\026\004\017\n\t\n\017 )0.5(\f\004\017\021\026\035\017 )0.5(\030\036\031\035\034\021\026\021\t )0.5(\023\030\017)]TJ /Span<>> BDC ( )Tj EMC /T1_2 1 Tf 0 Tw (\032)Tj /T1_1 1 Tf 0.619 Tw /Span<>> BDC ( )Tj EMC 18.778 0 Td (<)Tj /Span<>> BDC ( )Tj EMC (0,05. )Tj 0.032 Tw -18.778 -1.218 Td [(\221\021\026\021\017\f\021\017\004\036\f\022\017\005 )0.6(\026\027\026\035\017 )0.6(\023\030\024\r\024\007\017\035\f\016 )0.5(\023\030\017)]TJ /Span<>> BDC ( )Tj EMC 16.724 0 Td [(\023\024\n\024\013\017 )0.5(\023\030\024)]TJ 0 Tw (-)Tj -0.013 Tw -16.724 -1.218 Td [(\020\030\026\n\n\027\024\020\024 \024\002\036\f\023\036\004\036\027\017\016\ R studio \(ver)-10(sion 3.6.1; R stu)]TJ 0 Tw (-)Tj 0 -1.218 TD [(dio, Bost)17(on, Massa)-16.9(chuse)-12(t)-30(ts\).)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 42.5896 566.5158 Tm [(\033\034\020)21(\223)50(\r\241)46(\024)52(\026)45(\024\232)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0 Tc 0.144 Tw 10 0 0 10 42.5197 542.1598 Tm (\200 \023\036\030\017\024\007 \f)Tj /Span<>> BDC ( )Tj EMC (\024\022\021\016\002\030\016 2020 \023\024)Tj /Span<>> BDC ( )Tj EMC (\024\022\021\016\002\030\034 2022 \020\020. \r)Tj /Span<>> BDC ( )Tj EMC (\017\f)Tj 0 Tw (-)Tj -0.015 Tw T* (\f\035\036\007\024\r\026\027\017\036 \002\t\035\024 \r\022\035\033\004\036\ \027\024183 \023\026\006\017\036\027\021\026: 91 \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 )Tj 0.111 Tw T* (\230\203\230 \017)Tj /Span<>> BDC ( )Tj EMC (92)Tj /Span<>> BDC ( )Tj EMC (\227 \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \216\214\230. \222)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\t \230\203\230 \017\f\022\035\033\004\036\027 )Tj 0.12 Tw T* [(31 \023\026\006\017\036\027\021: )0.5(10)]TJ /Span<>> BDC ( )Tj EMC 6.702 0 Td (\227 \r)Tj /Span<>> BDC ( )Tj EMC 2.179 0 Td [(\f\r\016\017 )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC [(\027\026\030\031\001\036\027\017\036\n )0.5(\023\030\024\021\024\022\024\035\026 )]TJ 0.094 Tw -8.881 -1.218 Td (\(\024\021\022\026 \024\021 \023\030\024\r\036\007\036\027\017\016 \022\ \024\027\f\024\035\017\007\017\030\031\033\013\036\005 \b\017\n\017\024\021\ \036\030\026)Tj 0 Tw (-)Tj 0.085 Tw T* [(\023\017\017, )0.5(\023\030\024\r\036\007\036\027\017\036 )0.5(\022\024\030\024\021\022\024\020\024 )0.5(\022\031\030\f\026 )0.5(\214\230 \221\210\212 )0.5(25 \206\030 )0.5(\r\n\036)]TJ 0 Tw (-)Tj 0.281 Tw T* (\f\021\024 \023\030\024\035\024\027\020\017\030\024\r\026\027\027\024\020\ \024 \022\031\030\f\026 \216\214\230 \221\210\212 50\22654)Tj /Span<>> BDC ( )Tj EMC (\206\030\), )Tj 0.126 Tw T* (1)Tj /Span<>> BDC ( )Tj EMC 0.859 0 Td [(\023\026\006\017\036\027\021 )0.5(\017\f\022\035\033\004\036\027 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 8.912 0 Td [(\f\r\016\017 )0.5(\f\024 \f\n\036\030\021\034\033 )0.5(\024\021 )0.5(\022\024\030\024\027\026)]TJ 0 Tw (-)Tj 0.01 Tw -9.77 -1.218 Td (\r\017\030\031\f\027\024\005 \017\027\235\036\022\006\017\017 \027\026)Tj /Span<>> BDC ( )Tj EMC (\007\024\020\024\f\023\017\021\026\035\034\027\024\n \220\021\026\023\036\ , \031)Tj /Span<>> BDC ( )Tj EMC (1 \023\026)Tj 0 Tw (-)Tj 0.129 Tw T* (\006\017\036\027\021\026 \002\t\035\026 \r\t\016\r\035\036\027\026 \f\017\ \027\b\030\024\027\027\026\016 \026\007\036\027\024\022\026\030\006\017\027\ \024\n\026 )Tj 0.207 Tw T* (\f\017\020\n\024\r\017\007\027\024\005 \022\017\001\022\017, \036\013\036\ 19 \023\026\006\017\036\027\021\024\r \027\036 \016\r\017\035\017\f\034\ )Tj 0.087 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC (\022\024\027\021\030\024\035\034\027\t\005 \024\f\n\024\021\030 \023\024\ \f\035\036 \023\030\024\r\036\007\036\027\017\016 \027\036\024\026\007\255\ \033)Tj 0 Tw (-)Tj -0.005 Tw T* (\r\026\027\021\027\024\005 \021\036\030\026\023\017\017. \200)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \216\214\230 \017\f\022\035\033\004\036\027 21 \ \023\026\006\017\036\027\021: )Tj 0.116 Tw T* (9)Tj /Span<>> BDC ( )Tj EMC (\227 \r)Tj /Span<>> BDC ( )Tj EMC (\f\r\016\017 \f)Tj /Span<>> BDC ( )Tj EMC (\027\026\030\031\001\036\027\017\036\n \023\030\024\021\024\022\024\035\026\ , \031)Tj /Span<>> BDC ( )Tj EMC (\024\007\027\024\020\024 \023\026)Tj 0 Tw (-)Tj 0.165 Tw T* (\006\017\036\027\021\026 \002\t\035\026 \r\t\016\r\035\036\027\026 \f\017\ \027\b\030\024\027\027\026\016 \027\036\005\030\024\220\027\007\024\022\030\ \017\027)Tj 0 Tw (-)Tj 0.046 Tw T* (\027\026\016 \024\023\031\b\024\035\034 \023\030\016\n\024\005 \022\017\001\ \022\017, \017)Tj /Span<>> BDC ( )Tj EMC (\031 \024\007\027\024\020\024 \023\026\006\017\036\027\021\026 \002\t\035\ )Tj -0.013 Tw 23.244 36.534 Td (\r\t\016\r\035\036\027 \030\026\022 \027\026)Tj /Span<>> BDC ( )Tj EMC (\235\024\027\036 \016\r\036\027\027\024\020\024 \022\024\035\017\021\026\ , 10 \023\026\006\017\036\027\021\024\r )Tj -0.027 Tw T* (\027\036 \016\r\017\035\017\f\034 \027\026)Tj /Span<>> BDC ( )Tj EMC 5.903 0 Td [(\022\024\027\021\030\024\035\034\027\t\005 )0.5(\024\f\n\024\021\030 \023\024\f\035\036 )0.5(\023\030\024\r\036\007\036\027\017\016 )]TJ -0.025 Tw -5.903 -1.218 Td (\027\036\024\026\007\255\033\r\026\027\021\027\024\020\024 \035\036\004\036\ \027\017\016. \200)Tj /Span<>> BDC ( )Tj EMC (\024\002\013\036\005 \f\035\024\032\027\024\f\021\017 \017)Tj /Span<>> BDC ( )Tj EMC (\017\f)Tj 0 Tw (-)Tj 0.332 Tw T* (\f\035\036\007\024\r\026\027\017\016 \017\f\022\035\033\004\036\027\024 \ 52)Tj /Span<>> BDC ( )Tj EMC (\(28%\) \023\026\006\017\036\027\021\026. \230\026\022\024\036 )Tj 0.093 Tw T* (\002\024\035\034\001\024\036 \004\017\f\035\024 \r\t\002\t\r\001\017\b \017\ )Tj /Span<>> BDC ( )Tj EMC (\017\f\f\035\036\007\024\r\026\027\017\016 \002\024\035\034\027\t\b )Tj 0.015 Tw T* [(\r\024 \n\027\024\020\024\n \024\002\031\f\035\024\r\035\036\027\024 \023\ \026\027\007\036\n\017\036\005 C)12.9(OVID-19 \r)]TJ /Span<>> BDC ( )Tj EMC (2020\226)Tj 0.237 Tw T* (2022)Tj /Span<>> BDC ( )Tj EMC (\020\020. \003\027\026\004\017\021\036\035\034\027\024\036 \004\017\f\035\ \024 \023\026\006\017\036\027\021\024\r \023\036\030\036\027\036\f\035\017\ )Tj 0.124 Tw 0 -1.218 TD (\022\024\030\024\027\026\r\017\030\031\f\027\031\033 \023\027\036\r\n\024\ \027\017\033, \004\021\024 \023\024\r\035\017\016\035\024 \027\026)Tj /Span<>> BDC ( )Tj EMC (\024\021\022\026 )Tj 0.577 Tw 0 -1.218 TD [(\024\021 )0.5(\023\030\024\r\036\007\036\027\017\016 )0.5(\022\024\027\f\024\035\017\007\017\030\031\033\013\036\005 )0.6(\b\017\n\017\024\021\036\030\026\023\017\017. )]TJ 0.018 Tw T* (\207\t\035\026 \f\031\013\036\f\021\r\036\027\027\024 \026\021\030\031\007\ \027\036\027\026 \035\024\020\017\f\021\017\022\026. \212\030\031\020\017\ \n \024\002)Tj 0 Tw (-)Tj 0.034 Tw T* (\f\021\024\016\021\036\035\034\f\021\r\024\n \016\r\035\016\035\024\f\034\ \023\030\024\r\036\007\036\027\017\036 \022\024\030\024\021\022\024\020\ \024 \022\031\030\f\026 )Tj 0.065 Tw T* (\214\230, \027\036 \021\030\036\002\031\033\013\036\020\024 \007\035\017\ \021\036\035\034\027\024\005 \020\024\f\023\017\021\026\035\017\026\006\ \017\017, \r\n\036)Tj 0 Tw (-)Tj 0 -1.218 TD (\f\021\024 \023\030\024\035\024\027\020\017\030\024\r\026\027\027\024\020\ \024 \022\031\030\f\026 \216\214\230.)Tj 0.286 Tw 0 -1.218 TD [(\230\026\022\017\n \024\002\030\026\024\n, )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC [(\026\027\026\035\017 )0.5(\r\022\035\033\004\036\027\024 )0.5(60 \023\026\006\017\036\027\021\024\r, )]TJ 0.061 Tw 0 -1.218 TD [(\023\030\024\001\036\007\001\017\b )0.5(\230\203\230 \017)]TJ /Span<>> BDC ( )Tj EMC [(71 )0.5(\023\026\006\017\036\027\021, \023\024\035\031\004\017\r\001\017\b )0.5(\f\021\026\027\007\026\030\021)]TJ 0 Tw (-)Tj T* (\027\t\005 \022\031\030\f \023\030\024\035\024\027\020\017\030\024\r\026\ \027\027\024\005 \216\214\230 \(\217\017\f.)Tj /Span<>> BDC ( )Tj EMC (1\).)Tj /T1_2 1 Tf 0.513 Tw 0 -2.436 TD (\207\032\026\027\021\031\021\025\031 \202\032\205\033\033 \033\n)Tj /Span<>> BDC ( )Tj EMC (\n\t\021\n\027\021\020\003 \004\026\032\026\013\024\031\032\025\t\024\025\ \013\026\003 )Tj 0 Tw 0 -1.218 TD (\033\026\203\025\031\021\024\n\027)Tj /T1_1 1 Tf 0.241 Tw T* [(\206\030\031\023\023\t )0.5(\023\024\035\027\024\f\021\034\033 )0.6(\f\024\023\024\f\021\026\r\017\n\t )0.6(\023\024)]TJ /Span<>> BDC ( )Tj EMC 15.711 0 Td [(\024\f\027\024\r\027\t\n )0.5(\022\035\017)]TJ 0 Tw (-)Tj 0.353 Tw -15.711 -1.218 Td (\027\017\004\036\f\022\017\n \023\026\030\026\n\036\021\030\026\n \017)Tj /Span<>> BDC ( )Tj EMC (\b\026\030\026\022\021\036\030\017\f\021\017\022\026\n \024\023\031\b\024\ \035\017 )Tj 0 Tw T* (\(\230\026\002\035.)Tj /Span<>> BDC ( )Tj EMC (1\).)Tj /T1_2 1 Tf 0.039 Tw 0 -2.436 TD [(\222\n\003\033\023\026\031\021\024\021\n\t\024\022 )0.6(\025)]TJ /Span<>> BDC ( )Tj EMC 8.31 0 Td [(\033\031\032\031\021\n\t\025\003\n\t\024\022 )0.5(\021\031\n\026\030\b\007\027\026\021\024\021\n\017 )]TJ 0 Tw -8.31 -1.218 Td (\024\031\032\026\033\025\025)Tj /T1_1 1 Tf 0.092 Tw 0 -1.218 TD (\215\024\035\027\t\005 \022\031\030\f \027\036\024\026\007\255\033\r\026\ \027\021\027\024\005 \021\036\030\026\023\017\017 \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \230\203\230 )Tj 0.37 Tw T* (\026\r\036\030\001\017\035\017 51/60 \(85%\) \023\026\006\017\036\027\021\ \024\r \023\030\024\021\017\r 70/71 )Tj -0.017 Tw T* (\(99%\) \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \216\214\230, \030\026\035\017\004\017\016 \023\ \030\017)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\n \f\021\026\021\017\f\021\017\004\036\f\022\017 )Tj 0.087 Tw T* (\027\026\004\017\n\t \()Tj /T1_2 1 Tf 0 Tw (\032)Tj /T1_1 1 Tf 0.087 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,006\). \211)Tj /Span<>> BDC ( )Tj EMC (\024\007\027\024\020\024 \023\026\006\017\036\027\021\026 \r)Tj /Span<>> BDC ( )Tj EMC (\022\024\027\021\030\024\035\034)Tj 0 Tw (-)Tj 0.113 Tw T* (\027\024\005 \020\030\031\023\023\036 \216\214\230 \002\t\035\026 \023\030\ \036\030\r\026\027\026 \r)Tj /Span<>> BDC ( )Tj EMC (\f\r\016\017 \f)Tj /Span<>> BDC ( )Tj EMC (\030\026\r\017\021\017\036\n )Tj 0.175 Tw T* [(\021\016\032\036\035\024\005 )0.6(\035\031\004\036\r\024\005 )0.5(\030\036\026\022\006\017\017 )0.6(\(R)-12(T)20(OG )0.5(4\), )0.5(\024\002\031\f\035\024\r\035\036\027\027\024\005 )]TJ ET q /GS0 gs 453.543294 0 0 243.5695541 42.5196838 101.0361282 cm /Im0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 0 Tw 9 0 0 9 42.5197 90.1959 Tm (\022\t\217\210\b\002\220 1.)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf ( \213\023\n\013-\t\004\031\003\026 \025\t\t\023\031\030\n\027\026\021\025\ \002)Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 0 -1.2 TD [(F)-16(igure 1)47.1(.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf [( Block diag)14.1(ram of the study)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\021\032)50(\b)42(\032\231\027 \213\036)30.1(\005\t\033)30(\b)]TJ 52.896 0 Td (LEADING ARTICLE)Tj /T1_5 1 Tf 25 0 0 25 511.9769 56.0378 Tm (13)Tj ET endstream endobj 2581 0 obj <>stream AdobedC     '$''''$25552;;;;;;;;;;w   @7!1U"4AQu#23Taq&$BCSr %'()*56789:DEFGHIJRVWXYZbcdefghijstvwxyz?QsiU|ͧH OiyS^muG5C$t. Yi 1rDE,=vִd`(-ҺdnLx vyU=i |:);n?596 ,б -{{ٿxZZ̴ Zז8ጃ^ȹYuXh#-. _\1##y)c,mp/`vtg^ȈQ@m͎jpnhN2O0Q~-9b2 iwָj [=tk˞茓ӗ@0kn7gSQKp:Bwǐ#Wtg >s@1[EYI14@̆3#Ƒ㯈?**uxkDͷo]= }-jfvcm+۱rгkn1^@uKKj8rh>{h6j>fm PioSݪ* u;$0HKKIg8R[4(۝c\{#]vw_cʫlԼdo= _7TkIvDz8F6 '8A<}Ovz`LEX)Y)d'I ߔNA)8'~Rq:O#tx|7'?oN'I ߔNA)8'~Rq:O#tx|7'?oN'I ߔNA)8'~Rq:O#tx|7'?oN'I ߔNA)8'~Rq:O#{ m"rkAi""""""""""""""""9(_F껌P>h s%qdh/CtzrӧГ?_ބtn$;O;w'!:~۽ 9IwNvBNCtzrӧГ?_ބtn$;O;w'!:~۽ 9IwNvBNCtzrӧГ?_ބtn$;O;w'!:~۽ 9IwNvBNCtzrӧГ?_ބtn$;O;w/룸66< #QDqM"""""""""""" Ӿ7cwئsj妒hhLTL>HUsႆMC3:V.̻, o޹mI/y -Y@>}ѳ4q9%pZY$sx0ְj斿kde8X:>GbŤֆNE=OQ3in0 F\ \\F9#' Rn)Is3=cdnI-yi\42`,2誒1YH{2A/HWvAXt OonfKQM> ZhvX}| 1Ss. Nf9\9p)jꞨX*X%d[QKAɏS OncSN w6-Ԋ:=MkJsgYOM]rt>O0kd/2`5h!|{a\x2,9L!9%qyobHcT#wꏌ"UuM<84#G+7tV}pL8Jh.U5D]mdE{F^;OZweER[参+|ᥙ$o=Y}*Y\Fdq:v֜1퐹Q o9ԏ5g~}M7{4+9hGh;w|G_U;[=k71':BRop pΦ:_mcnUoZME˜>yLLlѴ1xÀ߻}vUCW{s7ܥzƺF5QKM 2@Rl>[ DDDDDDDDDDDDDDDDPC~CR 'o$н0[Z9ݔ}‚6T50F;7;hhq1Xg%<Ʀ8=dF$ds\xSdMqs =45sX $/+)*Im4@ |ScNXehˣnFs_'8kJx\M+#t piqξ$q5quP8k[# DDDDE<88+5젽 ȩDDDDDDDDDDDDԾ7cwئ)n%263c.-!;t;#juCt<2bGtoKywv^TYb1<:F7Uik?HvsξYhn|;lKi$7N1IQSsoT\W LωX^-<+8`&0s5gzv[%n1%K*u[#bwn3b9׉ A;Yŧ  w߸d{Ma5$4k8%渒7䯣tYURc:Iuq/מ`vRH7[a$6bWRic\Q@6'c蒎'4HZ 0Ln'>i-TuѾWT.ji08.dL""""""""""""""""(}[?~!SL.IClW9Z"kc6]b;m:0aڟcS)OOrպ&%lkc9hN͍,Iujj8L;+ :hj Jc4M 9LrumZ+8۔Eچ.΢umSA&C#K g4A4*m-ҋEPuL89߿xT{G.s_IqC&I+ZKtrɒC8}XlL7ccᝍ id4 qey[ɦ ifmƦ=> 瑇mܥEL3cߨ0Z߸=[ܷ'FjLIw YpR382'`t` 6oGlw٨3jɥ5M{{[' 5yj0I3"i~2ucmt쥚0] |rqOP $1An(]ӆfC3䌌mjK%ϭZ2qM&&98qn@[uϠca6Bi%lLc.v2>?6ģM,fE)1uu%[_Tl2ڊA $?i5IjELQ61W(.lH 4>T5젽 ȩDDDDDDDDDDDDվ7cwإDI#\8O0\meTT#Yl{k8.{o1TM6CF]tZi]Py^#Hn>6CGpꙟ 2:'/p 0Tt$PTgl1 82BN;i e[et>Fǻ\ j{+&87IC`v0H+r٪ik+Y]k6]B@4jw[o޹w;ʏ)k飍BYO欸ܭК<5QѸtR8;.+,oJ%F,7s)#vp(\'hI3 dÜqn\6 |f#$qlo,׀sʫ徎gE;rG҆91pi:?6Fq[Ħ.-$GOy92jlWL"YR9G Ө4m()t>7ds2w1f[|0JMJpnf# 4Umt-:"Nn[Lt̓:~ٙKff1J*Ƙ\ 9ʛk4;dDEdL""""""""""""""""(}[?~!SwZF KAuio\NI- OfKI .1c= $ i|N (#ϝ8:6EbcCZѸ7ۥ5rDtCy8ߎWUŀ8y<=.ۧedч f\09t6h[ ١nDnsN1jqr襠acZ*:d q[C8 NF*^t }ri451c^ dxWa}llTC,D=Lo ׻C]Nwt[-fq6M l><`e^UTհ>& @q\hmYt qy,Ϲ53iX4,=ܢ*vvip7fi74Fdžb#4˟۟ 믍CC8?[ϻqWX*l=t4 ȩ]9X ;9t*Y 択. I]ddXfZ3}TA5;)uu͌TFc ~1DoaVz yث]J|TQ>>>B%a99ܮMդkv@3QC+vaSh}߈|aC3h#s,Ts /0,σrA!RT4V/Em뉕~hAS7=X^]V3wZFV:6TC"kxgÉ-p.{6]1VIdcJkwzOGle*'E\i:v#(#:{p4Mh{K88Uh4m%sJNG:9]O{C_`2׺&Hٝ5cMQ1zxm%Ϩ7 󮎨bbwG=kYR> /ihvyX޾2VH 5+M'l59 qa%'~qھ ںa :77L&Vm4eIZ.bL|Nk,>SH9 5젽 ȩDDDDDDDDDDDD׾7cwئ&I$ˡplq-xhKۥ9WxVc-}br~$ou=~l={\ANDŽo]{zTÞV|~Z9БŁ 2w Ds8>zʺh*U8ippA.> v*Ks8m 20h=߃wĆzxh*fJظV8'GI3֎|w:Z/MF⤞ec%ഝzAt.TӴV9sA}kfgNFq|q#~ J4:CI8#qi{C2A# wO_$z57P;b_[#(fFC$ss矙~qs+97C< t[2wd`|+ӐFAˆV?¦>-)‡ٸ)qE; Ye$:Ap#wg4[L)ifjz[}Escn KCAۂ;eAKOM]VW»N=rJ~A$uDhTIw\w<ԲՕ3SS$q[Nr4j#=s5\UPٸG6?Z:6HぼTe$u'"9 [!a#p#*"diE¦qH^ DÃpx[U5w.QlRMue\p;,F؋{$3 +-/HiH %I1#$$Zm5RpZڃQ3ѫKck@i`o{ %H$Xc|uq\6E!eS*ؘ%nqĶj.f۔oA,17`V3TP\$`ݩ+,$ *W:DBX湅u*z47 3>u]8 Bh8[XmwB?cZ2g_,TxXa.y֌}6v +V$ Jz64hkFO^rJf8Y*d\i%> o&=u{ųJ+ s)Hg/$:%?|Sl36(,CO_2JK[2 qI gvcmgԹS7hku.F;O8.9ARTS%\a4 ]eT^EL""""""""""" о7cwإ#HZ!DCB!4x.#S>$"Kۆ2yv z94Q6q(aKs|U۠a&ZA^ט^f4:1T`g `{E%N+T)w1=83_n/[UciѾ*;ulGh..s4ዤߍ8\6Mʖ &d"t%C'x36K#rֲ9)S.杲C3^c8k qp+-O կ]A1.p =n$﾿.vi8׋r:(YMGO H:3w;dwPEO@%/#Kw /][UvEEbX灥'8φ| |O1KQ67wCp.\{~QOH)ꌰ#4uqn5nO0;횞kE9솬ʘr=n7öwzsA`H%+]d{8pPW[iO^i")lr=߄.lgD^W pnixF}QEJٶQ%+xg3[rӀ-anZ>Hu31j|U:˞Kݬcݼv.t($usa`:(nn;6K3^uVk4qKNy: o1۪UQB#s mdrC@qnrCW 駉Զ2Ӊ_+]~Ɯcwhs>Gu :b=HOC,K%ώ=骩h%͖لsc=!YYy8բK5gQyc{bZZ:y¯i# --, cp{ /l>[ DDDDDDDDDDDDDDDDPC~CS ]wS XX2INq_߬bH]3Nno[- 3~gjb21㑀BˆEH2L3ߎ6iWg :/d<~lym}Mә5KYDns`@hm B8LI7=_bju`eK]PdtB6w^dgwmqܯU%=\0XF+K r67N'8wWhW9ikl-ʮ)b^H{B2}Ӆc\ ppp^O3\iE#p#h7#<廗,xj:S-q `ͣc5g y\#pyn*Ӷ9.n#oy$`4vWֆTs)!a~4j;ѽڄ`ԳG {zF3N5jdnxjfL*4m#S\޶M}o02{Y޾&16*LbH{[;}_iWN+˰ֱ ~N2Ai{Q\h"CE' sΓ7(v_.魯csuK 2_m ҏ)Ap16j A$4; gu KTzq ]#s .4n.8oG mTQEU,pns[s7u"eT^EL""""""""""" Ѿ7cwئ线QC+vaSh}߈|aV,w(a{mSC^5ɘdž8n,FChn5H<`zNs\IU[mH[.6:79ێڰ0yT K_E#&eF$u6n%[m dp~ \XsG99 WWCOGnڗ2=Tɬ7 ^fb242Aso_c5>5͋`f92[|׳5 6Dz8I$ݧv2Ӽ?]M;M cnǸ ^[C g㛶-W4 w,6cIAxꬫqdB߽yk0SMqs&uO:p2Fݕ.-,#S6mLViӖuݼpP\MZi"{IwTe)Hn7*5!k*290Հ9uxfo\풞Wky|DsE$tk4cYnқ{u tw P\9kd<6먶_iLqJv#؆#NO Ֆ,J@FتtkCC܌9R ,MhcYxFM c2n^Gx"P.oŃ}nK4Rv#U%Uh]3e4rM:9ۜn@[\vGStki>Ǹ+ T,uJ1cd i|&sy݅kXڑ+s4Ŏz8k 99 KRIQ%Erjf!pn]% 4cqܹjuӳ O13H8. y82uϮKJ͙Z=_%Ŝ7Z`; {JݣB[tc.$=!9?ib1HNOnć''7LCC!! MBvHn0POALzl?ib1HNOnć''7LCC!! M|HzBr~t>$=!9?ib1HNOnć''7LCC!! QOoF.8<9VDDDDDDDDDDDDDDDEyMsST YjS>k^g}M|HzBr~t>$=!9?ib1HNOnć''7LCC!! M|HzBr~t>$=!9?ib1HNOnć/*]]q'ɧ /|;O]o7hXji☷;!! M|HzBr~t>$=!9?ib1HNOnć''7LCC!! M|HzBr~t>$=!9?ibm6 ʺڡW=k.sb56 o{MQ-}N?)DDDDDDDDDDDDDDDDDDDDDDDDDDDDDD\Om_4bo7jDDDDDDDDDDDDDDDDDDD@Q%o?Zu6-cCmm]興Q%o?Zu6-cCmm]興Q%}1KNiβ C(qM#cէ!rua/E z/XlKxxez^'V+^?9:^ՆN6W<~rua/E z/XlKxxez^'V+^?9:^ՆN6W<~rua/E z/XlKxxez^'V+^?9:^ՆN6W<~rua/E z/XlKxxez^/f&u|81lї98 \,nbڿi9yX>6 o&ވ*ghKYrxi NF⼺^ՆN6W<~rua/E z/XlKxxez^'V+^?9:^ՆN6W<~rua/E z/XlKxxez^'V+^?9:^ՆN6W<~rua/E z/XlKxxez^'V+^?9:^ՆN6W<~rua/E z/ c{eV55!WQ%kZe6>\|_.s { p'DDDE~8e /DDDDDPY%wmN-[W7/+؆Mڻ>Uҩd{ֹw7DDD_%H9rDDDDDEXx%,LRQkZe8>\|TM$x:NCQqVr=t* Z. 7 ۱V[GoPxjYp nsU1@Z\t`뾂Yp:`ʙe plHǑ78aCk췚 ڃgd >k#>TuFbKEw7>m1mysMNatpcC<_{[+m56XDմ0L4u_mL$FD.t`pQp!V=|q5ESQN0/,I seWk/[QP]ol"y$wڻRպKBhjtadN{ԗIi Xj@kIh=%j=ڛEDnZI4$\}]nөDDDDDDDDDDDErnM+g ;?l'鼛T"""ʽzU0Wxc?I262>IOSdsL7<7cnYnCF#kުZHq8hSYP]dLu3A972d sr^)mU,Զ=7G(_-25#gS"M3[μg鶋imM6Ծ_@ʙju0ǙsCsNH:za#. vm5-Ci8&mhZKxlh:A#$e6c!ꥱR'ΞFo]ִ48n7 l7XuCE-KXý*nm&S[|ycs9sI˱7AZ-AP=ҷWU7S$,p &=*+sc*k&;As枇e]J˧PsZ\uG%pmm=5k[uUF<43;Kl j%Tykez$wa;]hQ[!JYI䘥Q&уSS)DDEQWwY˔.vi|2hjL ELf){#ӡC;Ey7e}Ѳ6A͝n#s9/Fl:<8;5s¸aqp/>">7@x'κa[)[4lXL.G?m$[fuXi#uDy 0}m#hEi3glm։.An٘ɘfvK]3ND.x?6]-%5 ;)hl000?ȝ:Mkepox:L7Ѩt@"v9/,.9;mS; 122y5P:v5FjڴN{y;k}ԳsL5;S!3.qH立ROQSM "Ja9H.B"""""ϱ+;mԺu0?byͳdMICe^=*\حSWfblƀCvWgBm#I‰'SےttazgH)ݘ2 iEx ـ 0_M#dF9—1AoWM2&O#% I'2y.GlͅԲѾ7=Gfɼm JV cJ.n!9Xks/l#s)lQ5par H4nF1-sO1`)6^=-5[EHe GI upGkm!ĮR""""""""""""9W6y6$DDE{aBɴ3j#nILf5@'O7c9)E[sW SM Cx6A08c{ɴue$Lq#X]ޜ/vzJ*D8}|m:'%-#  mnԱ 6_azӒq #A$蝊\汤|pϸF5Ch)cX]hpq9Bm垔UAIYH9^WK5 $Had@8{H.Jڮ3`Id)k/7yF]TB-Y5dMKi5f= `\)x5uZ؞8g Wᡘ:NZA9.{bLmLªg&'Dɩ.H9yAU3q85RG×4Hp9<$6-,rҶ3QA/$43a}ɳO;#piS:ir׻Yx%E룑Gwwߔsj`;GsvK5Dw)^5-E29R@nR1 kFK??<5 QCgؕߝ]:DDDDDDDDDDDD\}W3/lA#d͒4 2C# "aks͌)**#ETē4k;h2=:y UM yGj24& 3ι{fC,TI,4:'{C%cÀ.$v)Ke+i4SJctŸn#IW;3Ism~J֖0Ai+mYbTljM_='Qi#/i TTHژ1-2b1OZKts}`yaUm#&6Z1y'zx'wqjWǘNx467绕Ij )LM fs|'S7*4TI%psL9<9Ȉ_dI]Q.vuL=G_AދSJw.L""""""""""""/ /Ҹ_웵wɵJ"""(}~GS_dI]Q6wvS)DDEQWw‹%fiYWwd i{dy:浪X'FdQr\i46@%=̆&͌e@\mwSimk紵p{94\s(X]P:í2sW۶M^hn &C uX&$/q4s\1^Um 3KWMVICCcҸhic4&xbjHݑmuwz:W5< C{ PV]ARxVQ<Tjw62G9™DDPY%wmN`~hi\[/MڻMڥ>UҩG~fͺb.Delz].Ƭc8J"(M]%핏Zh&Rtüpn7vYRWVۤ:j|F^3m]LH< ppo;g^%J@l{:Gh'WT-;&L55:wHl_jQS 3׵NiwhꚃLTUS_.7 ;Y+(E; iYxp#c$1QtFhi9ijLYco's/:m0"wHz56ݧw+LȤ ue9|zDNu 72imd̝('('9@ZB EFCLm{6u#8ꚇQh_=빱H6ӆG8U3F\ O] ݫ&sc`,$pU յ]DiO' 78?jaۍd QrdPƒ)|M&\ùL-Jj:hbXǪHZ +@nw7:k>G]D|(l7FcaI\Y{\[,ed/19nHkyEXx%,LRQ6U)DDEQWw‰-M$tf9͊N7Fis :Jz Hh#6Nр7/dQwk]mMeP*f:Xdmװ1iqWl]u\UrGuJlѼo.\Ի%pOJiM$x1ʍv\$jdt0D\ǹ@ `#Z8l+`|oQCgؕߝ]:DDDDDDDDDDDD^Q_ql7j}7jDDDP?W?J5Bk81>ucV=̯dEYlUu%#4N`E).:@{X6e}\O]+d{j1r2W@vksak(bpef;8ÄCn9\e*Q7QKhӧ hJZZIL᭮vFDmPgq_,381ue *{7׽ڤp=w1MTY)|OW%DG2=9hk8%ru;r;9_dtpUJ4T\1 7WGxk%>0$kX0KpZ\;x8>r6 e},2vEy e0>\|DD^55tMk'vW0\rt2ws/XaYiZٸX"[c#ٮyx iC_X.v uӾ0Kcr}VӰS&.0#$컭1|jƐh-n/۳__lq-•цΣݵ-Zjx>X&5.8߅۽Ԏ6Ԍ8}@3 O6 iu~l2:cX niq+]me+)&,z_&qv{Czme#_DuLl|2ŹnDbt;1sa 'I÷ oެ͍:G#ly0=AՂGl/yR+-yayivdoX#pdlok.s [* mDU|s8tM-h'r hh0M-x8ϼADPY%wmN`~hi\[/MڻMڥ>UҩDE5M$TW$$ Y$16\W.֩$[N'6Xˋ@7~>hsJf茱h[; xdsڰpp Լf.tZAtQ7 ڪyD {ݐ4o]]Q>hcLtчe$c+ߥ7{(zs|cv7C^O_Ydpvb3 3D}M̞֌d7 kn ,7۳Z)V^cXS##`epsKuo@5W121cuϹ{Q\L4rGSHvEy e0>\|DDQ:5MMA> hhsZ$cQqAXmz&P5Ք5Ї+IC[>X x+(ttbC+_ioi~-j -ak;d.v7:zflAo dN44No0+lMq}52j->LscpWUNRGG$R@_#_9h $nh}stVSh teny 7CN'uWS]*kkC l7NFll8P . ߃C2͵"YkH"^GҟWbeuwsve>X䩢5/M$Y <3|/k^i"mΦh\Fڇb]:^7n^kk$fktfh̥<HւGh>{UMʶ8t1pYE0>7E.; %c_%hb,)..Aj}]nөDDDDDDDDDDDE\3EPM+e;5j#鼛T"""ʽzU0W{]ڢ{㠢|Nu.RzA :J׻tż%SR]pqJZan<~/0_ 9I\f}3F$ s-n@si-m+MGq( dns.[ĩ(,0ZJ6ͬkX Px{].Ͻsl׊)ϫqVWnȄo gz^[_%04/6f!{xP[|.x6r9k>pa|oT1i$Ĕ"tx7ׅ=hH>hF:J~ Ya:#I :Owݕqj.J#<%3uqsF@?ohZ*zOy1dp]+ᩪYa3ӶNŠ 3 q;[35-\9$NI1†绑SHQ[!JYI䘥Q>vEy e0EmxKC8h$6g5[o{s]gr3P`Z454`75 ` h >}]nөDDDDDDDDDDDEYsii\)LZ{MڥQ| -88 ʽzU0 ::WJh#Ҝ$3^Ȉֱs/ƱhckF |;*+d>K7{)<Q^f[xJȈJ43ǁRLR{vFSݹx_ѩ'n^=Wju1IۗULR{vFSݹx_Ѫ#j6m.X5uU5s 6[-ߨh!]:Wz<5fH`߿=tDDDDDDDDDEWU8աpNr{~RU[^GIơ[<{""ϱ+;mԺu0k;2M*V̛=m+̱14屈)\ IǺ&ӓx'i7ޜ>NI/IZrM&zOӒo97}}ɼ^QlfWl dTq1BLB8uxuhH˫-leS[| y% [C"q޿Q|;*+d>K7{)<Q653y*u2>\|U_c md>fp uøw)M=]%n1U PLa '#W?6" -3}I* dk:jwe~DB T\]ss >s=vl4\b a͙,vDpvG $i.'BE#ncOkD3< c{\ׯ =}WT xumLX83:A`rXM$Rs.e'H8v8k>0Բv']g4@Ӱ0cW52lRDm7}j)Kl:39Ǻ(}SA% A42y8̐sg6]]MEAp2b`i`*R'8w9͍qV9ݽ}Dڶm$ѲC5X:5t,0 %vss+eռ-M;c8{q&#gK}o>//i+pvEHKuλ 0:F:Z~^6:4!1{d-O:Wś#) kӆp7azOK&Ot!gc^ tpz}+""/{El)fe'b@Q653y("""+;q as\mԷZ9(kCk̰^FHkCAq.v%}""{CXIZw=IimsacZ׽;dWR""ϱ+;mԺu0k;2M+e>ɋO{T"""ʽzU0t7Cxb${]spс`.D\}-֒JA(Ǿ"G>2ӏ{$q.v9$DDDDDDD_/RO$.Q.{%U!SH쯠EP)DDDDDD_M Nce{X\[q .p 4ݠKhcxcCy# QrykHK}s_ >){'ql.k漷9 N^舊k>ĮR""""""""""""944 &-=mRg*߇QT""""/mx6 ڈɨ. mM9΁/Xp ;IŧBDDDDDDD_/RO$.Q.{%U!SH쯠EP)DE {Op!luGaDc2o@/Wqsϔ)*8d Q$:7;ZI>uʢw7)tp~gQߒN;*h/rn;t 9X:1iܤ)n*AXM]ʦLx3 X{@NԻC~ɥI%UO#Nid =Cwc VtVKq(k ga뉈a#6z⯙کTxFI<ޚs5O6}} qci=u=]®\9\)t*w6G)' wiH[+IpuI5l5 .Da>K nx*w%|'&FJH`A_o޸ultB)ݢ `bx|ϿO:窡[ųݮԲ 41Ӊ!<kwيk抺 4K=͟Hs p19bTj᪞GAXaDfGiktY\j+23#k8~!}dsT%( G4tM!Y#pC0|I(8w ת"(}KSʬfa݉He'Mڥ>UҩDESpnUZW44IIR Ir9 ҆p[.Uѹ#l$Xbډ=ˆsR2n3/c"STl1 K]ޢ tGGn=4何s옃95Ux5,ֆI)[d54n:ab;kܾc.=iHр=^=)ѱi# 6_dI]Q&oU?2=G_AދSʢ> !%kdnG1Á^RZs9GJqxn%1Gl$A% ѻKk"0hȄ1GTbg"en$oo6q=56>(i@ll1 ߽y`T92=I!KZz`wn6z$2}0$@=' 8+[-) vL9ˆ纎۞c/Ll:wۇ[n2;:Ds}#C_CLֵ: ntu;}#()^o."\qwzm}+H w}5؍ 1cp1Sp;AM),#~r8_}]nөDDDDDDDDDDDESkF-iu7jDDDP?W?J+v$R@ώΉj%@;,ZsghfFq\1^rY2Z*g%F㥸00е["F50[qܿE#!I 4W1jGP>&gc14ihn11cym+ c+&9c( 8;1}SPOĮR""""""""""""i5BvG어ɵK""(}~GS_dI]Q&sW$jmC}j0{!mU>~ /%\s8妸-5TbwncwWZ(ڦ[n l!२#t[ouESmUޮ.+J$cW@×[qSW{MK0j8{yȍ-9rHcIqvhjXiɯ[y6Vq}ǵҶ gp`:W9c7$=*-h |F9]+nxQy356wOuLhWzu zInTkup}1{Z\5 A3`w:W(sƸe !,᛭lyw1&ܛY5[0e sWUh+/"+#1\|ZidZuBC:qWWG~hWΑi9Ӫ*q:Ŷ@\3d2qndO N3~{KiղSDD5/J%C˴ }r +ie,ͷ"2\u@_'ϧwκfJ5,ԙ㧕 m_ I ~۹+n1IbWH^Xa GYMrb;bFGp[UUVB؟?|Ne_9vG 1gǣ6f/:Jif)11KOwX䪩E\[.IH8@x2#3 ^XnqqEbW~vۿtayT4!Q#KZ{Mڥ>Uҩ %ݨiuG5nkN8̦Z }]ʚ6FEČ$P$=v㵜evS_.UW N:i'  Zr^A48_U5VFFz8i,,[<I\uWr2{|rUHbx2pdaIOrrQ@I#Wv6Q\)}[y< ̸ JO l]g55B"k0 Sqw\7XT2)đY69iߞ}NKsZ%ddlXL`oin!@mm|K!kE:p̞#!`Ϯ){ k+;_GV}AHc\Ncz6jK;q@X2H5/p;9~+fB#SG13AQ aـ{,bPnrԲP%42,׿|έW]#lTPdtTOΌ9dFa;*)SMG3b|Ȱ\X7po$VISTjB"GuҶhㅎSr> 4:{CF\3ͪi *hbk\0ts.eʢk#k\inA%˚1h{98?Q[!JYI䘥Q&sݽ!M""(z-@İ; s07v}.:]-uM5\' F>ǽ9,q ZH޸vfll4^ FTOJuHm{\ZN QҲӱ<\1FӸ[SCCLE[ZDO -swqw6Z!1Ijv_Y;O]v(헵:۝úDQ%_:p9 15PPLF]7sn 멫HF2VqM3b(#zr{e4mvE=򻃄\N86ǹ<6ees4ـw6Iֺi#_N&lCI\FM [˅TuM !$I#@loXZkƠFV5 kDa{FP1–gN9^T5lu;ၤ+l=ҹ.4dPFe`c-񤎴"Wll!2{Lu4lne'Zv:V$8&Zd%hy٥hO p_+46gwjR8Y[jv_;;' fm.vtޥDXIlm Ĺ$%}}KSʧ Zo&.}L""(V>I#6?{!${-fED$||]ypNbiPE<̚':wZιsNp\v(mGL= {!%:K'9\N;3=eA\p{À .+e%LA,|eqp%~$xx ӻ+5jJX[r#.. hv~Mc dZ2;guNm=D%bfTF#v88 боHqkp$go:eL/6'NK# m`Z A1j"gHPK+ՀK'hdQB;YQ<ݼ nٚ к7.-Zp9MW5\yCdHoΣT/{El)fe'b@Q&zۯ~jDDDPe}z.>ZL""""""""""""""ϱ+;mԺu0{_oݑ%=mR興g*߇QT"""""""""""""/{El)fe'b@Q&ۯ~jDDDPe}z.>ZL"".Jۃ)$z ˜ٴ <󶠊V6fgN7y;o_z#U%,MNP Z<恝A޾iv*:zZI䒦M!3bi s nI89窘};\idibݹ4 a}E:E+-,Pcr# s:+/Sme d`޵' Elϩ^Dj\ ZrF;KU$1ƢVD׼pxVC#ô47[9yʴJw.L""""""""""""/9`!Q{sz:cT"""ʽzU09I$F1Y 24v~5OOT~5OOT~5OOT~5OOT~5OOT~5OOT~5OOT~5OOT~5OOT~5OOT~5OOT~5OOT~5OOT~5OOT]oڋ }!5ҽ LC,s`gvN+ """"""""""""_H?씴wcT"""~|ʩVqi#pz2Fy;iWMܾJS|/S]7r*_ENnTOt}:黗R*u?Uw/T~_%KWMܾJS|/S]7r*_ENnTOt}:黗R*u?Uw/T~_%KWMܾJS|/S]7r*_ENnTOt}:黗R*u?Uw/T~_%KWMܾJS|/S]7r*_ENnTԑzoJTe5IpF^Aylm  @Q.{ÿW,4oa"RoSQ.{ÿW,4Q;J{O0)DDDDDDDDDDDDDDDDDDDQ6ˏǻy$S(_OTNL aQr]nWԚx)<7y;SG[WԓFUվgfg{:OWdDDDDDDDDDDDDDDDDDDDDDDDDDDDDDD\ͺB}A@d1#QHnl%5 Y())s@'whfDDDDDDDDDDDDDDDDDDD@ԥN\*[}gmrrpxFyʖm'*[}gmrrpxFyʖm'*[}gmrrpxFyʖm'*[}gl;\rl==2Zz|;74`'ʖm'*[}gmrrpxFyʖm'*[}gmrrpxFyʖm'*[}gmrrpxFyʖm'*[}gmrrpxFyʖm'*[}gmrrpxFyʖm'*[}gmrrpxFyʖm'*[}gmrrpxFyʖm'*[}gmrrpxFyʖm'*[}gmrrpxFyʖm'*[}gmrrpxFyʖm'*[}gmrrpxFyʖm'*[}gmrrpxFyʖm'*[}gmrrpxFyʖm'*[}gmrrpxFyʖm'*[}gmrrpxFyʖm'*[}g.yT1UDxHp d(-/bg3%D|ǜn{LpxFyʖm'*[}gmrrpxFyʖm'*[}gmrrpxFyʖm'*[}gmrrpxFyz]O+% 8&75|bW""""""""""""ֽm\qGElok !vr <^jr <^jr <^jr <^jr <^jr <^jr <^jr <^jr <^jr <^jr <^jr <^jr <^jr <^jr <^jr <^jr <^jr <^jr <^jr <^jr <^jr <^jr <^jr <^jr <^jr <^jr <^jr <^jr <^jr <^jr <^jr <^jr <^jflntvG4r{C:^h^* QAMru2f!hvtΗNpwss/lRy 2\~O02 FCdv}-'p(R薞iե̧iws{[v`"}woCmAm0!|ۦ42ΌExF|T[ZT$ նK }iA^h.s0IW 6RBk!JFCHd=젣s\k0A:Te/A%])8> 74=4jvϼ6-beM;X`8G7\Wc^Cf㯂Ɨ.-a]4{9WSSD-QX9i\u <^jr <^jr <^jr <^jr <^jr <^jr <^jr <^jr <^jr <^jr <^jr <^jr <^jr <^jr <^jr <^jr <^jr <^jr <^jr <^jr <^jr <^jr <^jr <^jr <^jr <^jr <^jr <^jr <^jr <^jr <^jr <^jr <^jr <^jr <^jr <^jS_/P#!`&N""""""""""" ׾7cwئ̏si:Z2޳+6 =-’4IRII<%iYcAW]5 ¶zswڙ&aCu4ǽy]Z+Ҧ_%H^UG',lEGPicc=D늢723 aν{;4&}Ֆj,4i,qwA_=M^&m]=I}]M=;Cu0;S2wv=F__[S0Y {YϯlyHv 1AzMZ\2AL1з,<WfP_mԲZmMx$$26 Zw0G6O@ dl9Yd. &P.]E c&TW vL=ys5Q#ZTU#QoKSIhŧKI$;VyeWIIke@1p$a,ap*ZS Diq o 2m]U'MkS->5C-IFdQ%IUNl_x90{jFi)*S0@>2ZyƦ|p7e썳l QNV͕UGXdT5'f1)cqw/fXml+i,ѧѧ;eHg֛ӺHqI"7惸e:Jn3Vg ~eZѾ9*2]4/"I3ClǺ\ lM,Q~cm9㸤,U b2dpg 2.R~c;9yݜӠҹ4\CË"-.egiplMM\ K|Ϋt͑~.:iHo ցι'a4΍GGi n#1 ڋgV$oeUn8Ćic!9[vkIQ57 6I#ƣ*A C)D""""""""""""Q endstream endobj 2586 0 obj <>stream endstream endobj 2579 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.171 Tw 10 0 0 10 70.8661 724.8299 Tm (\027\036\024\026\007\255\033\r\026\027\021\027\024\005 \021\036\030\026\023\ \017\017 \023\024\r\t\001\026\036\021 \004\026\f\021\024\021\031 \023\024\ \035\027\t\b )Tj 0.013 Tw 0 -1.218 TD (\024\021\r\036\021\024\r \024\023\031\b\024\035\017 \023\030\016\n\024\005\ \022\017\001\022\017, \r)Tj /Span<>> BDC ( )Tj EMC (\f\030\026\r\027\036\027\017\017 \f\024 \f\021\026\027)Tj 0 Tw (-)Tj T* (\007\026\030\021\027\024\005 \023\030\024\035\024\027\020\017\030\024\r\026\ \027\027\024\005 \216\214\230.)Tj T* (\025\030\017\021\036\030\017\017 \r\022\035\033\004\036\027\017\016:)Tj 0.026 Tw T* (\226)Tj /Span<>> BDC [( )-241( )]TJ EMC 1.056 0 Td (\023\024\007\023\017\f\026\027\027\024\036 \007\024\002\030\024\r\024\035\ \034\027\024\036 \017\027\235\024\030\n\017\030\024\r\026\027\027\024\036\ \f\024)Tj 0 Tw (-)Tj T* (\020\035\026\f\017\036 \027\026)Tj /Span<>> BDC ( )Tj EMC (\031\004\026\f\021\017\036 \r)Tj /Span<>> BDC ( )Tj EMC (\017\f\f\035\036\007\024\r\026\027\017\017;)Tj 0.169 Tw -1.056 -1.218 Td (\226)Tj /Span<>> BDC [( )-98( )]TJ EMC 1.056 0 Td (\020\017\f\021\024\035\024\020\017\004\036\f\022\017 \023\024\007\021\r\036\ \030\032\007\036\027\027\026\016 \026\007\036\027\024\022\026\030\006\017\ \027\024\n\026 )Tj -0.004 Tw T* (\023\030\016\n\024\005 \022\017\001\022\017 \027\017\032\027\036\026\n\023\ \031\035\016\030\027\024\020\024 \024\021\007\036\035\026 cT2-4N0-)Tj 0 Tw T* (2M0 \017)Tj /Span<>> BDC ( )Tj EMC (\f\030\036\007\027\036\026\n\023\031\035\016\030\027\024\020\024 \024\021\ \007\036\035\026 \f\2302-T4N1-2M0;)Tj 0.466 Tw -1.056 -1.218 Td (\226)Tj /Span<>> BDC [( )199( )]TJ EMC 1.056 0 Td (\024\002\013\036\036 \f\024\f\021\024\016\027\017\036 \002\024\035\034\027\ \024\020\024 \023\024)Tj /Span<>> BDC ( )Tj EMC [(\001\022\026\035\036 EC)13(OG0-2 )]TJ 0 Tw T* (\002\026\035\035\026.)Tj -1.056 -1.218 Td (\025\030\017\021\036\030\017\017 \017\f\022\035\033\004\036\027\017\016:\ )Tj 0 -1.218 TD (\226)Tj /Span<>> BDC [( )-267( )]TJ EMC 1.056 0 Td (\r\024\030\026\f\021 \n\024\035\024\032\036 18 \017)Tj /Span<>> BDC ( )Tj EMC (\f\021\026\030\001\036 75 \035\036\021;)Tj -1.056 -1.218 Td (\226)Tj /Span<>> BDC [( )-267( )]TJ EMC 1.056 0 Td (\030\036\006\017\007\017\r \030\026\022\026 \023\030\016\n\024\005 \022\017\ \001\022\017;)Tj 0.707 Tw -1.056 -1.218 Td (\226)Tj /Span<>> BDC [( )440( )]TJ EMC 1.056 0 Td (\027\026\035\017\004\017\036 \f\017\027\b\030\024\027\027\024\005 \023\036\ \030\r\017\004\027\024-\n\027\024\032\036\f\021\r\036\027\027\024\005 )Tj 0 Tw 0 -1.218 TD (\024\023\031\b\024\035\017 \007\030\031\020\024\005 \035\024\022\026\035\ \017\026\006\017\017;)Tj -0.02 Tw -1.056 -1.218 Td (\226)Tj /Span<>> BDC [( )-287( )]TJ EMC 1.056 0 Td (\023\030\036\007\001\036\f\021\r\031\033\013\026\016 \035\031\004\036\r\026\ \016 \021\036\030\026\023\017\016 \027\026)Tj /Span<>> BDC ( )Tj EMC (\024\030\020\026\027\t \n\026\035\024)Tj 0 Tw (-)Tj T* (\020\024 \021\026\026;)Tj -0.233 Tw -1.056 -1.218 Td (\226)Tj /Span<>> BDC [( )-500( )]TJ EMC (\002\036\030\036\n\036\027\027\024\f\021\034;)Tj T* (\226)Tj /Span<>> BDC [( )-500( )]TJ EMC (\035\026\022\021\026\006\017\016;)Tj 0 Tw T* (\226)Tj /Span<>> BDC [( )-267( )]TJ EMC 1.056 0 Td (\027\026\035\017\004\017\036 \024\021\007\026\035\036\027\027\t\b \n\036\ \021\026\f\021\026\024\r;)Tj 0.445 Tw -1.056 -1.218 Td (\226)Tj /Span<>> BDC [( )178( )]TJ EMC 1.056 0 Td (\027\026\035\017\004\017\036 \f\024\023\031\021\f\021\r\031\033\013\017\b\ \026\002\024\035\036\r\026\027\017\005 \r)Tj /Span<>> BDC ( )Tj EMC (\f\021\026\007\017\017 )Tj 0 Tw T* (\007\036\022\024\n\023\036\027\f\026\006\017\017.)Tj -0.036 Tw -1.056 -1.218 Td [(\215\036\030\r\017\004\027\026\016 )0.6(\021\024\004\022\026 )0.5(\017\f\f\035\036\007\024\r\026\027\017\016: )0.6(\004\026\f\021\024\021\026 )0.5(\023\024\035\027\t\b )0.6(\024\021\r\036)]TJ 0 Tw (-)Tj T* (\021\024\r \024\023\031\b\024\035\017 \(\022\035\017\027\017\004\036\f\022\ \017\b \017)Tj /Span<>> BDC ( )Tj EMC (\023\026\021\024\n\024\030\235\024\035\024\020\017\004\036\f\022\017\b\)\ .)Tj 0.084 Tw T* [(\200\021\024\030\017\004\027\t\036 )0.6(\021\024\004\022\017 )0.5(\017\f\f\035\036\007\024\r\026\027\017\016: )0.6(\004\026\f\021\024\021\026 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 18.095 0 Td (\f\021\030\031\022\021\031\030\026 )Tj 0.008 Tw -18.095 -1.218 Td (\017\027\021\030\026- \017)Tj /Span<>> BDC ( )Tj EMC (\023\024\f\035\036\024\023\036\030\026\006\017\024\027\027\t\b \024\f\035\ \024\032\027\036\027\017\005 \023\024)Tj /Span<>> BDC ( )Tj EMC (\022\035\026\f\f\017)Tj 0 Tw (-)Tj 0.038 Tw T* [(\235\017\022\026\006\017\017 Cl)-16(av)-15.9(ien-Dind)-16(o, \004\026\f\021\024\021\026 \024\f\035\024\032\027\036\027\017\005 \035\ \031\004\036\r\024\005 )]TJ -0.045 Tw T* (\021\036\030\026\023\017\017 \023\024)Tj /Span<>> BDC ( )Tj EMC [(\001\022\026\035\036 R)-12(T)20(OG \017)]TJ /Span<>> BDC ( )Tj EMC (\b\017\n\017\024\021\036\030\026\023\017\017 \023\024)Tj /Span<>> BDC ( )Tj EMC (\001\022\026\035\036 \021\024\022)Tj 0 Tw (-)Tj 0.268 Tw T* [(\f\017\004\027\024\f\021\017 NCI-CT)35(C, \004\026\f\021\024\021\026 R0-\030\036\036\022\006\017\005. \217\026\ \f\004\201\021\027\t\005 )]TJ 0.259 Tw T* (\030\026\n\036\030 \r\t\002\024\030\022\017 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\n\024\013\027\024\f\021\017 \017\f\f\035\036\007\024\r\026\027\017\016 \ 80% )Tj 0.298 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (0,5% \212\222 \f\024\f\021\026\r\017\035 \023\024)Tj /Span<>> BDC ( )Tj EMC (146 \023\026\006\017\036\027\021\024\r \r)Tj /Span<>> BDC ( )Tj EMC (\022\026\032\007\031\033 )Tj 0 Tw T* (\020\030\031\023\023\031.)Tj -0.092 Tw T* (\203\026 \026\n\002\031\035\026\021\024\030\027\024\n \220\021\026\023\036\ \023\030\024\r\024\007\017\035\017 \f\002\024\030 \032\026\035\024\002 \ \017)Tj /Span<>> BDC ( )Tj EMC (\026\027\026\n)Tj 0 Tw (-)Tj 0.171 Tw T* (\027\036\026. \212\017\026\020\027\024 \031\f\021\026\027\026\r\035\017\ \r\026\035\017 \027\026)Tj /Span<>> BDC ( )Tj EMC (\024\f\027\024\r\026\027\017\017 \007\026\027\027\t\b )Tj 0.236 Tw T* [(\235\017\017\022\026\035\034\027\024\020\024, )0.6(\035\026\002\024\030\026\021\024\030\027\024\020\024 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 14.129 0 Td (\017\027\f\021\030\031\n\036\027\021\026\035\034\027\024\020\024 )Tj -0.024 Tw -14.129 -1.218 Td (\024\002\f\035\036\007\024\r\026\027\017\016, \022\024\021\024\030\024\036\ \r\022\035\033\004\026\035\024 \r)Tj /Span<>> BDC ( )Tj EMC (\f\036\002\016 \030\036\022\021\024\f\022\024\023\017\033 )Tj 0.051 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\022\024\035\024\027\024\f\022\024\023\017\033 \f)Tj /Span<>> BDC ( )Tj EMC (\002\017\024\023\f\017\036\005. \204\026\020\027\017\021\027\024-\030\036\ \024\027\026\027\f\027\031\033 )Tj -0.035 Tw T* [(\021\024\n\024\020\030\026\235\017\033 )0.5(\(\204\217\230\) )0.6(\023\030\017\n\036\027\016\035\017 )0.6(\007\035\016 )0.5(\f\021\026\007\017\030\024\r\026\027\017\016 )0.5(\030\026\022\026 )]TJ -0.006 Tw T* (\023\030\016\n\024\005 \022\017\001\022\017, \026)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\032\036 \007\035\016 \017\031\004\036\027\017\016 \220\235\ \235\036\022\021\026 \024\021 \027\036\024)Tj 0 Tw (-)Tj 0.263 Tw T* [(\026\007\255\033\r\026\027\021\027\024\005 )0.6(\021\036\030\026\023\017\017, )0.5(\023\030\017\n\036\027\016\016 )0.6(\001\022\026\035\031 )0.5(mrTRG )0.5([8]. )]TJ 0.126 Tw T* (\212\035\016 \007\017\026\020\027\024\f\021\017\022\017 \024\021\007\026\ \035\036\027\027\t\b \n\036\021\026\f\021\026\024\r \023\030\017\n\036\027\ \016\035\017 )Tj 0.194 Tw T* (\n\031\035\034\021\017\f\023\017\030\026\035\034\027\031\033 \022\024\n\023\ \034\033\021\036\030\027\031\033 \021\024\n\024\020\030\026\235\017\033 \ \(\025\230\) )Tj 0.161 Tw T* (\024\030\020\026\027\024\r \020\030\031\007\027\024\005 \022\035\036\021\ \022\017 \017)Tj /Span<>> BDC ( )Tj EMC (\002\030\033\001\027\024\005 \023\024\035\024\f\021\017 \f)Tj /Span<>> BDC ( )Tj EMC (\r\027\031)Tj 0 Tw (-)Tj 0.119 Tw T* (\021\030\017\r\036\027\027\t\n \022\024\027\021\030\026\f\021\017\030\024\ \r\026\027\017\036\n \017/\017\035\017 \204\217\230 \002\030\033\001\027\ \024\005 )Tj 0 Tw T* (\023\024\035\024\f\021\017 \f)Tj /Span<>> BDC ( )Tj EMC (\r\027\031\021\030\017\r\036\027\027\t\n \022\024\027\021\030\026\f\021\017\ \030\024\r\026\027\017\036\n.)Tj 0.061 Tw T* (\215\024\f\035\036 \023\024\035\031\004\036\027\017\016 \007\024\002\030\ \024\r\024\035\034\027\024\020\024 \017\027\235\024\030\n\017\030\024\r\026\ \027\027\024\020\024 )Tj -0.008 Tw T* (\f\024\020\035\026\f\017\016 \022\026\032\007\024\n\031 \023\026\006\017\ \036\027\021\031, \023\024\007\b\024\007\016\013\036\n\031 \023\024\007 \ \022\030\017\021\036)Tj 0 Tw (-)Tj -0.071 Tw T* (\030\017\017 \r\022\035\033\004\036\027\017\016, \002\t\035 \023\030\017\ \f\r\024\036\027 \017\027\007\017\r\017\007\031\026\035\034\027\t\005 \027\ \024\n\036\030 )Tj 0.277 Tw T* (\030\026\027\007\024\n\017\026\006\017\017 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\023\024\n\024\013\017 \020\036\027\036\030\026\021\024\030\026 \023\024\ \f\035\036\007\024\r\026)Tj 0 Tw (-)Tj 0.102 Tw T* (\021\036\035\034\027\024\f\021\017 \f\035\031\004\026\005\027\t\b \004\017\ \f\036\035 \017\027\021\036\030\027\036\021 \030\036\f\031\030\f\026 \231\ www.)Tj -0.022 Tw T* (\f\035\031\004\026\005\027\024\036-\004\017\f\035\024.\030\235\232. \200\ )Tj /Span<>> BDC ( )Tj EMC (\f\024\024\021\r\036\021\f\021\r\017\017 \f)Tj /Span<>> BDC ( )Tj EMC (\023\030\017\f\r\024\036\027\027\t\n )Tj 0.43 Tw T* (\017\027\007\017\r\017\007\031\026\035\034\027\t\n \027\024\n\036\030\024\ \n \023\026\006\017\036\027\021\t \002\t\035\017 \030\026\007\036)Tj 0 Tw (-)Tj 0.135 Tw T* (\035\036\027\t \027\026)Tj /Span<>> BDC ( )Tj EMC (\007\r\036 \020\030\031\023\023\t: 1\))Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\026 \216\214\230)Tj /Span<>> BDC ( )Tj EMC (\227 \f\021\026\027\007\026\030\021\027\t\005 )Tj 0.273 Tw 23.244 64.543 Td (\023\030\024\035\024\027\020\017\030\024\r\026\027\027\t\005 \022\031\030\ \f \027\036\024\026\007\255\033\r\026\027\021\027\024\005 \b\017\n\017\024\ \035\031)Tj 0 Tw (-)Tj 0.055 Tw T* (\004\036\r\024\005 \021\036\030\026\023\017\017 \221\210\212 50\22654)Tj /Span<>> BDC ( )Tj EMC (\206\030 \f)Tj /Span<>> BDC ( )Tj EMC (\023\030\017\036\n\024\n \022\026\023\036\006\017\021\026\002\017)Tj 0 Tw (-)Tj 0.127 Tw T* (\027\026 825)Tj /Span<>> BDC ( )Tj EMC (\n\020/\n)Tj 0 Tw 5.83 0 0 5.83 354.7894 703.8039 Tm (2)Tj 0.127 Tw 10 0 0 10 357.7044 700.4739 Tm ( \007\r\026 \030\026\026 \r)Tj /Span<>> BDC ( )Tj EMC (\f\031\021\022\017 )Tj /T1_1 1 Tf (per os)Tj /T1_0 1 Tf ( \r)Tj /Span<>> BDC ( )Tj EMC (\007\027\017 \035\031\004\036\r\024\005 )Tj 0.175 Tw -5.44 -1.218 Td (\021\036\030\026\023\017\017; 2\))Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\026 \230\203\230)Tj /Span<>> BDC ( )Tj EMC (\227 \023\030\024\035\024\027\020\017\030\024\r\026\027\027\t\005 \022\031\ \030\f )Tj 0.07 Tw T* (\035\031\004\036\r\024\005 \021\036\030\026\023\017\017 \221\210\212 50\226\ 54)Tj /Span<>> BDC ( )Tj EMC (\206\030 \f)Tj /Span<>> BDC ( )Tj EMC (\023\030\017\036\n\024\n \022\026\023\036\006\017\021\026)Tj 0 Tw (-)Tj 0.034 Tw T* [(\002\017\027\026 )0.5(825)]TJ /Span<>> BDC ( )Tj EMC (\n\020/\n)Tj 0 Tw 5.83 0 0 5.83 363.1675 667.2699 Tm (2)Tj 0.034 Tw 10 0 0 10 366.0825 663.9399 Tm [( )0.5(\007\r\026 \030\026\026 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC (\f\031\021\022\017 )Tj /T1_1 1 Tf [(per )0.5(os)]TJ /T1_0 1 Tf [( )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC [(\007\027\017 )0.5(\035\031\004\036\r\024\005 )]TJ 0.139 Tw -6.278 -1.218 Td (\021\036\030\026\023\017\017 \017)Tj /Span<>> BDC ( )Tj EMC (3)Tj /Span<>> BDC ( )Tj EMC (\022\024\027\f\024\035\017\007\017\030\031\033\013\017\b \022\031\030\f\026\ \b\017\n\017\024\021\036\030\026\023\017\017 )Tj -0.013 Tw 0 -1.218 TD (\023\024)Tj /Span<>> BDC ( )Tj EMC [(\f\b\036\n\036 XEL)35(O)17(X \r)]TJ /Span<>> BDC ( )Tj EMC (\r\t\032\017\007\026\021\036\035\034\027\t\005 \023\036\030\017\024\007 \ \023\024\f\035\036 \024\022\024\027)Tj 0 Tw (-)Tj 0 -1.218 TD (\004\026\027\017\016 \035\031\004\036\r\024\005 \021\036\030\026\023\017\ \017.)Tj 0.263 Tw T* (\214\031\004\036\r\031\033 \021\036\030\026\023\017\033 \(\214\230\) \023\ \030\024\r\024\007\017\035\017 \r)Tj /Span<>> BDC ( )Tj EMC (\030\036\032\017\n\036 \f\021\026\027)Tj 0 Tw (-)Tj 0.123 Tw T* [(\007\026\030\021\027\024\020\024 \235\030\026\022\006\017\024\027\017\030\ \024\r\026\027\017\016, )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC (\023\030\017\n\036\027\036\027\017\036\n \021\036\b\027\024)Tj 0 Tw (-)Tj 0.057 Tw T* (\035\024\020\017\017 \017\027\021\036\027\f\017\r\027\024-\n\024\007\031\ \035\017\030\024\r\026\027\027\024\005 \035\031\004\036\r\024\005 \021\036\ \030\026\023\017\017 )Tj 0.105 Tw 0 -1.218 TD [(\(IMR)-12(T\), \030\026\024\r\026\016 \007\024\026 \(\217\212\) 2\206\030, \f\031\ \n\n\026\030\027\026\016 \007\024\026 \(\221\212\) )]TJ 0.175 Tw 0 -1.218 TD (50\22654)Tj /Span<>> BDC ( )Tj EMC (\206\030. \212\035\016 \024\006\036\027\022\017 \035\031\004\036\r\t\b \030\ \036\026\022\006\017\005 \023\030\017\n\036\027\016\035\017 )Tj 0.002 Tw 0 -1.218 TD [(\001\022\026\035\031 R)-12(T)20(OG [9]. \212\035\016 \024\006\036\027\022\017 \021\024\022\f\017\004\036\ \f\022\017\b \030\036\026\022\006\017\005 \017\f)]TJ 0 Tw (-)Tj T* [(\023\024\035\034\024\r\026\035\017 \001\022\026\035\031 NCI-CT)35.1(C v5.0 [10].)]TJ 0.652 Tw T* (\215\024 \024\022\024\027\004\026\027\017\017 \027\036\024\026\007\255\033\ \r\026\027\021\027\024\020\024 \035\036\004\036\027\017\016 \004\036\030\ \036 )Tj 0.052 Tw 0 -1.218 TD (7\22612)Tj /Span<>> BDC ( )Tj EMC (\027\036\007\036\035\034 \023\024\f\035\036 \026\r\036\030\001\036\027\017\ \016 \035\031\004\036\r\024\005 \021\036\030\026\023\017\017 \r\t)Tj 0 Tw (-)Tj 0.445 Tw 0 -1.218 TD [(\023\024\035\027\016\035\017 )0.5(\022\024\027\021\030\024\035\034\027\024\036 \024\002\f\035\036\007\024\r\ \026\027\017\036 )0.5(\(\204\217\230 \n\026\035\024\020\024 )]TJ 0.058 Tw 0 -1.218 TD (\021\026\026, \025\230 \024\030\020\026\027\024\r \020\030\031\007\027\024\ \005 \022\035\036\021\022\017 \017)Tj /Span<>> BDC ( )Tj EMC (\002\030\033\001\027\024\005 \023\024\035\024\f\021\017 )Tj 0.169 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC 0.838 0 Td [(\r/\r )0.5(\022\024\027\021\030\026\f\021\017\030\024\r\026\027\017\036\n\). )0.5(\215\030\017)]TJ /Span<>> BDC ( )Tj EMC 13.04 0 Td [(\027\026\035\017\004\017\017 )0.6(\023\030\017\027\026\022\024\r )]TJ 0.129 Tw -13.879 -1.218 Td (\023\024\035\027\024\020\024 \024\021\r\036\021\026 \(\023\024\035\027\t\ \005 \030\036\020\030\036\f\f)Tj /Span<>> BDC ( )Tj EMC (\227 mrTRG1 \023\024)Tj /Span<>> BDC ( )Tj EMC (\007\026\027)Tj 0 Tw (-)Tj 0.052 Tw T* (\027\t\n \204\217\230 \n\026\035\024\020\024 \021\026\026\) \024\002\f\035\ \036\007\024\r\026\027\017\036 \007\024\023\024\035\027\016\035\017 \007\ \026\027)Tj 0 Tw (-)Tj 0.234 Tw T* (\027\t\n\017 \220\027\007\024\030\036\022\021\026\035\034\027\024\020\024\ \031\035\034\021\030\026\r\031\022\024\r\024\020\024 \017\f\f\035\036\007\ \024\r\026)Tj 0 Tw (-)Tj 0.11 Tw T* (\027\017\016, \030\036\022\021\024\030\024\n\026\027\024\f\022\024\023\017\ \017 \017/\017\035\017 \r\017\007\036\024\022\024\035\024\027\024\f\022\024\ \023\017\017. )Tj 0.17 Tw T* (\215\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\023\024\035\027\t\n \022\035\017\027\017\004\036\f\022\017\n \024\021\r\ \036\021\024\n \024\023\031\b\024\035\017 )Tj 0.588 Tw T* (\017\027\235\024\030\n\017\030\024\r\026\035\017 \024)Tj /Span<>> BDC ( )Tj EMC (\r\024\n\024\032\027\024\f\021\017 \026\035\034\021\036\030\027\026\021\ \017\r\027\024\020\024 )Tj 0.039 Tw T* (\023\024\007\b\024\007\026 \r)Tj /Span<>> BDC ( )Tj EMC (\030\026\n\022\026\b \f\021\030\026\021\036\020\017\017 \253\027\026\002\ \035\033\007\036\027\017\016 \017)Tj /Span<>> BDC ( )Tj EMC (\r\t\032\017\007\026)Tj 0 Tw (-)Tj 0.082 Tw T* [(\027\017\016\273, )0.5(\022\024\021\024\030\024\036 \r\022\035\033\004\026\036\021 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC [(\f\036\002\016 \024\002\016\026\021\036\035\034\027\024\036 )0.5(\r\t\023\024\035)]TJ 0 Tw (-)Tj -0.026 Tw T* [(\027\036\027\017\036 )0.5(\024\002\f\035\036\007\024\r\026\027\017\016 )0.5(\022\026\032\007\t\036 3 \n\036\f\016\006\026 )0.5(\027\026)]TJ /Span<>> BDC ( )Tj EMC 17.083 0 Td (\023\030\024\021\016\032\036\027\017\017 )Tj 0.175 Tw -17.083 -1.218 Td (\023\036\030\r\t\b \007\r\031\b \035\036\021 \007\017\027\026\n\017\004\036\ \f\022\024\020\024 \027\026\002\035\033\007\036\027\017\016. \211)Tj /Span<>> BDC ( )Tj EMC (\023\026)Tj 0 Tw (-)Tj 0.141 Tw T* [(\006\017\036\027\021\024\r \002\036 \023\024\007\021\r\036\030\032\007\036\ \027\027\024\020\024 )0.5(\023\024\035\027\024\020\024 \022\035\017\027\017\004\036\f\022\024)]TJ 0 Tw (-)Tj 0.201 Tw T* (\020\024 \024\021\r\036\021\026 \r\t\023\024\035\027\016\035\017 \b\017\030\ \031\030\020\017\004\036\f\022\024\036 \r\n\036\001\026\021\036\035\034\f\ \021\r\024 )Tj 0.07 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\024\002\255\036\n\036 \023\026\030\006\017\026\035\034\027\024\005 \017\ \035\017 \021\024\021\026\035\034\027\024\005 \n\036\024\030\036\022\021\ \031\n\220\022)Tj 0 Tw (-)Tj -0.042 Tw T* (\021\024\n\017\017 \017\035\017 \002\030\033\001\027\024-\023\030\024\n\036\ \032\027\024\f\021\027\024\005 \220\022\f\021\017\030\023\026\006\017\017\ \023\030\016)Tj 0 Tw (-)Tj 0.067 Tw T* (\n\024\005 \022\017\001\022\017 [11]. \025\026\004\036\f\021\r\024 TME \024\ \006\036\027\017\r\026\035\017 \r)Tj /Span<>> BDC ( )Tj EMC (\f\024\024\021\r\036\021)Tj 0 Tw (-)Tj 0.044 Tw T* (\f\021\r\017\017 \f)Tj /Span<>> BDC ( )Tj EMC [(\020\030\026\007\026\006\017\036\005 Q)-16(uir)-24(k)10(e P. [12]. \221\021\026\007\017\030\024\r\026\027\017\036 \030\026\022\026\ )]TJ 0.462 Tw T* [(\024\f\031\013\036\f\021\r\035\016\035\017 )0.5(\f\024\020\035\026\f\027\024 \022\035\026\f\f\017\235\017\022\026\006\017\ \017 )0.5(TNM 8-\020\024 )]TJ 0.193 Tw T* [(\023\036\030\036\f\n\024\021\030\026 [13]. \214\036\004\036\002\027\t\005\ )0.5(\023\026\021\024\n\024\030\235\024 \024\006\036\027\017\r\026\035\017 )]TJ 0 Tw T* (\023\024)Tj /Span<>> BDC ( )Tj EMC [(\001\022\026\035\036 R)-19.9(y)22(an [14].)]TJ 0.049 Tw T* (\230\016\032\036\f\021\034 \023\024\f\035\036\024\023\036\030\026\006\017\ \024\027\027\t\b \024\f\035\024\032\027\036\027\017\005 \024\006\036\027\ \017\r\026\035\017 )Tj 0.179 Tw T* (\023\024)Tj /Span<>> BDC ( )Tj EMC [(\001\022\026\035\036 Cl)-16(av)-16(ien-Dind)-15.9(o [15]. \215\030\017)]TJ /Span<>> BDC ( )Tj EMC (\r\t\016\r\035\036\027\017\017 \027\036\f\024)Tj 0 Tw (-)Tj 0.189 Tw T* (\f\021\024\016\021\036\035\034\027\024\f\021\017 \022\024\035\024\030\036\ \022\021\026\035\034\027\024\020\024 \026\027\026\f\021\024\n\024\026 \023\ \024\f\035\036\007)Tj 0 Tw (-)Tj 0.366 Tw 0 -1.218 TD (\027\033\033 \024\006\036\027\017\r\026\035\017 \r)Tj /Span<>> BDC ( )Tj EMC (\f\024\024\021\r\036\021\f\021\r\017\017 \f)Tj /Span<>> BDC ( )Tj EMC (\022\035\026\f\f\017\235\017\022\026\006\017\005 )Tj 0.317 Tw 0 -1.218 TD (\204\036\032\007\031\027\026\030\024\007\027\024\005 \017\f\f\035\036\007\ \024\r\026\021\036\035\034\f\022\024\005 \020\030\031\023\023\t \023\024\ )Tj /Span<>> BDC ( )Tj EMC (\017)Tj 0 Tw (-)Tj 0.003 Tw 0 -1.218 TD (\031\004\036\027\017\033 \030\026\022\026 \023\030\016\n\024\005 \022\017\ \001\022\017 \(\202, \200)Tj /Span<>> BDC ( )Tj EMC (\017\035\017 \221)Tj /Span<>> BDC ( )Tj EMC (\f\021\036\023\036\027\017\) [16]. )Tj -0.027 Tw T* (\200\f\036\n \024\023\036\030\017\030\024\r\026\027\027\t\n \023\026\006\ \017\036\027\021\026\n \023\024\f\035\036 \035\036\004\036\027\017\016 \030\ \036\022\024)Tj 0 Tw (-)Tj T* (\n\036\027\007\024\r\026\035\017 \007\017\027\026\n\017\004\036\f\022\024\ \036 \027\026\002\035\033\007\036\027\017\036 [1].)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.01 Tc 0.018 Tw 14 0 0 14 303.3769 115.9298 Tm [(\032\024)52(\026)45(\024\031\032\024\031\224\034\032\027\031\030)5( \026\022\026)-10(\r\031\020)]TJ 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0 Tc -0.013 Tw 10 0 0 10 303.3071 91.5738 Tm [(\212\026\027\027\t\036 )0.5(\002\024\035\034\027\t\b \002\t\035\017 )0.5(\r\027\036\f\036\027\t \r)]TJ /Span<>> BDC ( )Tj EMC [(\220\035\036\022\021\030\024\027\027\031\033 )0.5(\021\026\002\035\017)]TJ 0 Tw (-)Tj 0.059 Tw T* [(\006\031 Micr)-31.9(osof)-28(t A)16(CCES)17.1(S 2019 for W)-16(ind)-16(o)-14(ws. \203\036\023\030\036\030\t\r\027\t\036 )]TJ 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0 Tw 7.5 0 0 7.5 70.8661 759.8869 Tm [(\021\032)50(\b)42(\032\231\027 \213\036)30.1(\005\t\033)30(\b)]TJ 52.896 0 Td (LEADING ARTICLE)Tj -52.896 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 23, \023\0221)69(, 202)69(4)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 23, \023\0221)69(, 202)69(4)]TJ /T1_4 1 Tf 25 0 0 25 27.2651 56.0378 Tm (12)Tj ET endstream endobj 2578 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\235\225\225\016\n)-10(\026\220\r\001\025\006)-10(\026\216 \026)11(\025\026)11(\013\007\216\001\025\203 \001\016\025\013\201\230\212\r\013\001\026\001\025\ \203 \026)11(\016\002\013\221\220\220 \r\022\007\016\017\016\001\220\220 \002\013\n\013\ )]TJ 0 -1 TD [(\221\002\205\024\025\203 \n\220\n\220. \033\016\222)21(\215\007\216)21.1(\026)10.9(\013\026\020 \002\013\001\201\025\024\220\222\220\002\025\r\013\001\001\025\ \202)10(\025 \220\006\006)-9.9(\007\016\201\025\r\013\001\220\205)]TJ 39.131 1 Td [(Ef)-31(fectiv)12(eness of th)11(e total neoadju)10.1(v)10(ant th)11(er)21.1(apy in r)31(ectal )]TJ 2.292 -1 Td [(cancer tr)31(eatment. Results of th)11(e r)21(andomiz)10(ed trial)]TJ ET 0 0 0 1 K 1 j 1 J [0 2.997]0 d /GS1 gs q 1 0 0 1 46.0167 520.8533 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 43.0197 520.8533 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q [0 2.997]0 d q 1 0 0 1 46.0167 483.6455 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 43.0197 483.6455 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q 0 j 0 J q 1 0 0 1 42.5197 429.5764 cm 0 0 m 453.543 0 l S Q BT 0 0 0 1 k /T1_1 1 Tf -0.021 Tw 9 0 0 9 90.7087 730.4919 Tm [(P)45(A)45(TIENT)-9.9(S )0.5(A)53(ND )0.6(METHODS: )0.6(patients )0.7(with )0.6(histologically )0.6(p)46(rov)13(en )0.6(rectal )0.6(carcinoma )0.6(w)12(ere )0.6(randomly )0.5(assigned )0.6(in )0.5(tw)12(o )0.5(g)14(roups: )]TJ -0.003 Tw 0 -1.111 TD [(in the TNT )0.5(g)13.9(roup )0.5(af)-45.9(ter the )0.5(neoadjuv)16(ant )0.5(CRT 50\22654)]TJ /Span<>> BDC ( )Tj EMC 19.694 0 Td [(Gy )0.5(with capecitabine )0.6(3 consolid)26(ation courses of )0.5(XELO)20(X )0.5(w)12(ere done, )]TJ 0.03 Tw -19.694 -1.111 Td [(in the CTR g)14(roup)]TJ /Span<>> BDC ( )Tj EMC [(\227 con)11(v)13(entional neoadjuv)16.1(ant CRT 50\22654)]TJ /Span<>> BDC ( )Tj EMC [(Gy with capecitabine. A)14(t the end of the treatment, ef)-40(fect )]TJ 0.106 Tw T* [(w)13(as assessed by MRI using the mrTR)21(G scale. F)12(or patients with a full clinical response, who hav)12.9(e refused surg)12(er)-43(y)42(, )]TJ 0.128 Tw T* [(\253w)13(atch&w)13(ait\273 app)46(roach w)13(as used. F)12(or o)13(thers ef)-40(fect of neoadjuv)16.1(ant therap)12(y w)13(as ev)16(aluated by pathomor)-18(phology )]TJ 0.002 Tw 0 -1.111 TD [(using the Ryan scale. The p)46(r)-37(imar)-43(y endpoint of study w)13(as the com)16(plete response rate \(clinical and pathomor)-18(phologi)]TJ 0 Tw (-)Tj 0.033 Tw 0 -1.111 TD [(cal\). Second)26(ar)-43(y endpoints of study)12(: freq)14.1(uency and structure of intraoperativ)13(e and postoperativ)13(e com)16(plications, the )]TJ 0.085 Tw T* [(rate )0.6(of )0.6(g)14(rade )0.6(3\2264 )0.6(to)14(xicity )0.6(of )0.6(radio)13(therap)12.1(y )0.5(and )0.6(chemo)13.1(therap)12(y)42(, )0.6(R0-resection )0.6(rates. )0.6(The )0.6(study )0.5(w)13(as )0.6(registered )0.5(on )0.5(the )]TJ 0.023 Tw T* [(ClinicalT)56.1(r)-37(ials.gov \(N)22(CT04747951\).)]TJ -0.015 Tw T* [(RESUL)30(T)-10(S: betw)12.1(een October 2020 and October 2023, 183 patients w)12(ere included in the randomized study)12.1(: 91 patients )]TJ 0.031 Tw T* [(in the TNT g)14(roup and 92 patients in the CRT g)14(roup. A)14(t median \(Q1, Q3\) follow-up per)-37(iod 24 \(14; 28\) months, com)]TJ 0 Tw (-)Tj 0.008 Tw T* [(plete clinical response occur)-15.9(red in 23% \(14/60\) of TNT patients and in 7% \(5/71\) of THL patients \ \(p)]TJ /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0.008\). The )Tj 0.041 Tw T* [(pCR )0.6(rate )0.6(w)12.9(as )0.6(20% )0.6(\(9/45\) )0.5(in )0.6(the )0.6(TNT )0.6(g)13.9(roup )0.6(and )0.6(8% )0.6(\(5/66\) )0.6(in )0.5(the )0.6(CRT )0.6(g)14(roup )0.5(\(p)]TJ /Span<>> BDC ( )Tj EMC 31.415 0 Td (=)Tj /Span<>> BDC ( )Tj EMC 0.773 0 Td [(0.05\). )0.6(The )0.5(freq)14(uency )0.5(of )0.5(dev)13(elop)]TJ 0 Tw (-)Tj -0.009 Tw -32.189 -1.111 Td [(ment of to)14(xic reactions of deg)14(ree 3-4, the rate and structure of intra- and postoperativ)13(e com)16(plications, as w)12(ell as the )]TJ 0.034 Tw 0 -1.111 TD [(rate of R0 resection of the g)14(roup did no)13(t dif)-40(fer signif)-42.9(icantly)32(. The to)13(tal rate of Grade 3\2264 to)14(xicity)42(, rate of intra- and )]TJ 0.023 Tw 0 -1.111 TD [(postoperativ)13.1(e com)16(plications, R0-resections rate did no)13(t dif)-39.9(fer betw)12(een tw)12(o g)14(roups.)]TJ 0.119 Tw T* [(C)21(ON)22(CLUSION: p)46(reliminar)-42.9(y results of a randomized study demonstrated the ef)-40(fectiv)12.9(eness and safety of to)13(tal neo-)]TJ 0.023 Tw T* [(adjuv)16(ant therap)12(y in rectal cancer treatment.)]TJ /T1_2 1 Tf 0.01 Tc -0.01 Tw 8 0 0 8 42.5596 545.2226 Tm [(KEYW)22(ORDS:)]TJ /T1_1 1 Tf 0 Tc 0.023 Tw 4.948 0 Td [( rectal carcinoma, neoadjuv)16(ant therap)12(y)42(, to)13(tal neoadjuv)16(ant therap)12.1(y)]TJ /T1_2 1 Tf 0.01 Tc 0.018 Tw -4.948 -1.909 Td [(CONFLICT)5( OF)5( INTERESTS:)]TJ /T1_1 1 Tf 0 Tc 0.023 Tw 10.434 0 Td ( The authors declare no conflicts of interest)Tj /T1_2 1 Tf 0.037 Tc 0.21 Tw -10.434 -2.617 Td [(F)3.2(O)-4.6(R)8.7( C)-17.5(I)-15.6(T)45.5(A)37.5(T)-24.5(I)-1.3(ON:)]TJ /T1_3 1 Tf 0.023 Tc 0.219 Tw 6.654 0 Td [( S)-6.1(y)-13.5(c)-10.2(h)-15.1(e)-15.8(v)]TJ /Span<>> BDC ( )Tj EMC [(S)-9.6(.)-9.8(I)-10.3(.)-23.5(, R)-30.3(y)-19.6(b)-17.7(a)-11.3(k)-3.6(o)-10.3(v)]TJ /Span<>> BDC ( )Tj EMC [(E)-5.6(.)15(G)-11.6(.)-23.5(, A)-11.7(l)-23.7(e)-16.1(k)-39.6(s)-22.9(e)-25.2(e)-15.8(v)]TJ /Span<>> BDC ( )Tj EMC [(M)-7.1(.)40.6(V)39.7(.)-23.5(, C)-15.9(h)-15.1(e)-12.1(r)-35.9(n)-14.9(y)-28.9(s)-8.8(h)-10.9(o)-10.3(v)]TJ /Span<>> BDC ( )Tj EMC [(S)-9.6(.)40.6(V)39.7(.)-23.5(, P)-0.8(o)-9.3(n)-11.9(o)-9.2(m)-8.3(a)-10.1(r)-19.1(e)-11.5(n)-8.8(k)-3.7(o)]TJ /Span<>> BDC ( )Tj EMC [(A)-23(.)-23.9(A)-23(. Ef)-62.5(f)-28.5(e)-19.1(c)-41.5(t)-46.2(i)-14.5(v)-18.7(e)-11.5(n)-16.1(e)-22.8(s)-22.3(s o)-12.1(f t)-26.1(h)-15.1(e t)-21.9(o)-15.8(t)-36.8(a)-11.4(l n)-16.1(e)-21(o)-32.1(-)]TJ 0.218 Tw -6.659 -1.2 Td [(a)-13(d)-16.3(j)-3.5(u)-14.9(v)-28.4(a)-7.6(n)-17.3(t )0.5(t)-26.1(h)-15.1(e)-12.1(r)-30.8(a)-8.8(p)-19.6(y )0.5(i)-3.2(n )0.5(r)-19.1(e)-19.1(c)-41.5(t)-36.8(a)-11.4(l )0.5(c)-21.5(a)-7.6(n)-10(c)-9.7(e)-12.1(r )0.5(t)-30.8(r)-19.1(e)-13(a)-18.2(t)-26(m)-16.7(e)-11.4(n)-17.4(t)-29.3(. )0.5(R)-6.7(e)-22.8(s)-8.8(u)-8.4(l)-15.4(t)-48.9(s )0.5(o)-12.1(f )0.5(t)-26.1(h)-15.1(e )0.5(r)-30.8(a)-7.6(n)-14.5(d)-11.1(o)-9.2(m)-14.5(i)-8.3(z)-14(e)-21(d )0.5(t)-30.8(r)-56.4(i)-5.1(a)-11.4(l)-31.7(. )]TJ /T1_1 1 Tf 0.033 Tc -0.033 Tw 36.106 0 Td [(K)13.9(ol)3.6(op)2.4(r)3.1(o)3.4(k)-19.2(t)2.2(ol)3.6(o)-3.3(g)-13.2(i)6.7(a)5.8(.)]TJ /T1_3 1 Tf 0.013 Tc 0.228 Tw 7.019 0 Td [( )0.5(2)-18.9(0)-13.8(2)-1.2(4;2)-20.3(3)-4(\()27.7(1)34.3(\))4.5(:)10.9(1)4.1(0)-42.9(\226)1.8(2)-19(0)-3.4(.)-10.3( )0.5(\()-10.9(i)-13.2(n)-10.3( )0.5(R)-16.5(u)-31.9(s)-32.3(s)-25.5(.)33.2(\).)13( )]TJ 0.032 Tc -0.032 Tw -43.125 -1.2 Td [(h)-8.2(t)-40.4(t)-20.4(p)-9.7(s)1(:)10.9(/)93.7(/)45.5(d)-2.1(o)-3.5(i)8.8(.)11.7(o)-2.8(r)-7.7(g)-13.8(/)20.2(1)23(0)15.5(.)3.4(3)16.9(3)-6.9(8)10.3(7)13.6(8)9(/)16.9(20)18.3(7)7.1(3)-4.3(-)50.2(7)19.7(5)9.4(56)-17.7(-)18.7(20)5.2(2)17.8(4)-19.5(-)18.7(2)-1.3(3)-4.3(-)64.1(1)35.9(-)64.1(1)23(0)-24.4(-)18.7(20)]TJ /T1_2 1 Tf 0.01 Tc -0.026 Tw 0.005 -2.617 Td [(\026\020\021\033\030)5( \020\036\017)5( \013\033\021\033\013\023\030\037\023:)]TJ /T1_1 1 Tf 0 Tc -0.021 Tw 10.489 0 Td ( \207\020\006\031\027 \207\031\032\202\031\017 \215\202\n\032\031\027\025\ \006, \225\210\213\214 \253\217\240\215\037 \013\n\023\n\033\032\n\013\024\ \n\023\n\202\025\025 \025\003\031\021\025 \201.\217.)Tj /Span<>> BDC ( )Tj EMC (\212\020\204\025\004\273 \240\025\021\016\030\032\026\027\026 \212\n\t\t\ \025\025, \205\023.)Tj /Span<>> BDC ( )Tj EMC (\207\026\023\002\003\026 \201\030\025\023\002, )Tj 0.023 Tw -10.494 -1.2 Td (\030.)Tj /Span<>> BDC ( )Tj EMC (2, \240\n\t\013\027\026, 123423, \212\n\t\t\025\002; e-mail: info@gnck.r\ u)Tj /T1_2 1 Tf 0.01 Tc 0.147 Tw 0.005 -1.2 Td [(ADDRESS)5( F)13(OR)5( C)19(ORRESPONDEN)23(CE:)]TJ /T1_1 1 Tf 0 Tc 0.152 Tw 14.309 0 Td [( Sychev S.I., Ryzhikh N)18(ational Medical R)21(esearch Center of Colop)46(roctology)42(, Salyama Adilya st., 2, Moscow)52.1(, )]TJ 0.023 Tw -14.314 -1.2 Td [(123423, R)22(ussia; e-mail: info@gnck.ru)]TJ 0 Tw 0 -2.792 TD (\200\026\024\026 \033\n\t\024\205\033\023\031\021\025\002)Tj /Span<>> BDC ( )Tj EMC (\227 01.12.2023)Tj /Span<>> BDC ( )Tj EMC 19.488 0 Td (\n\t\023\031 \030\n\032\026\005\n\024\013\025)Tj /Span<>> BDC ( )Tj EMC (\227 19.12.2023)Tj /Span<>> BDC ( )Tj EMC 18.78 0 Td (\032\025\021\002\024\n \013)Tj /Span<>> BDC ( )Tj EMC (\033\205\005\023\025\013\026\203\025\025)Tj /Span<>> BDC ( )Tj EMC (\227 12.02.2024)Tj ( )Tj -38.268 -1.375 Td (Received)Tj /Span<>> BDC ( )Tj EMC (\227 01.12.2023)Tj /Span<>> BDC ( )Tj EMC 19.488 0 Td (Revised)Tj /Span<>> BDC ( )Tj EMC (\227 19.12.2023)Tj /Span<>> BDC ( )Tj EMC 18.78 0 Td (Accepted for publication)Tj /Span<>> BDC ( )Tj EMC (\227 12.02.2024)Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 42.5896 371.6679 Tm (\023\023\034\226\034\022\031\034)Tj 0 0 0 1 k /GS1 gs /T1_3 1 Tf 0 Tc -0.032 Tw 10 0 0 10 42.5197 347.3119 Tm (\025\024\n\002\017\027\017\030\024\r\026\027\027\024\036 \035\036\004\036\ \027\017\036 \016\r\035\016\036\021\f\016 \f\021\026\027\007\026\030\021\ \024\n \r)Tj /Span<>> BDC ( )Tj EMC (\035\036)Tj 0 Tw (-)Tj 0.017 Tw 0 -1.218 TD [(\004\036\027\017\017 )0.5(\002\024\035\034\001\017\027\f\021\r\026 \002\024\035\034\027\t\b )0.5(\030\026\022\024\n \f\030\036\007\027\036- )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC (\027\017\032\027\036)Tj 0 Tw (-)Tj 0.072 Tw T* (\026\n\023\031\035\016\030\027\024\020\024 \024\021\007\036\035\026 \023\ \030\016\n\024\005 \022\017\001\022\017 III \f\021\026\007\017\017 \017\035\ \017 II )Tj -0.018 Tw T* (\f\021\026\007\017\017 \f)Tj /Span<>> BDC ( )Tj EMC (\022\024\n\023\030\024\n\036\021\017\030\024\r\026\027\027\024\005 \035\026\ \021\036\030\026\035\034\027\024\005 \020\030\026\027\017\006\036\005 )Tj 0.18 Tw T* [(\030\036\036\022\006\017\017 )0.5([1]. )0.6(\215\030\017\n\036\027\036\027\017\036 )0.5(\007\026\027\027\024\020\024 )0.5(\023\024\007\b\024\007\026 )0.6(\f\027\017\017)]TJ 0 Tw (-)Tj 0.137 Tw T* (\035\024 \004\026\f\021\024\021\031 \n\036\f\021\027\t\b \030\036\006\017\ \007\017\r\024\r \007\024)Tj /Span<>> BDC ( )Tj EMC (3\2265%, \024\007\027\026\022\024, \027\036 )Tj 0.334 Tw T* (\023\030\017\r\036\035\024 \022)Tj /Span<>> BDC ( )Tj EMC (\031\r\036\035\017\004\036\027\017\033 \024\002\013\036\005 \023\030\024\ \007\024\035\032\017\021\036\035\034\027\024\f\021\017 )Tj 0.04 Tw T* (\032\017\027\017. \200\036\007\031\013\026\016 \023\030\017\004\017\027\ \026 \f\n\036\030\021\017 \031)Tj /Span<>> BDC ( )Tj EMC (\007\026\027\027\024\005 \022\026\021\036\020\024\030\017\017 )Tj 0.391 Tw T* (\002\024\035\034\027\t\b \016\r\035\016\036\021\f\016 \027\036 \035\024\022\ \024\030\036\020\017\024\027\026\035\034\027\t\005 \030\036\006\017\007\017\ \r, )Tj -0.015 Tw T* (\026)Tj /Span<>> BDC ( )Tj EMC (\024\021\007\026\035\036\027\027\t\036 \n\036\021\026\f\021\026\t [2,3]\ . \203\026\027\026\004\036\027\017\036 \f\017\f\021\036\n\027\024\005 )Tj 0.109 Tw T* (\b\017\n\017\024\021\036\030\026\023\017\017 \r)Tj /Span<>> BDC ( )Tj EMC (\026\007\255\033\r\026\027\021\027\024\n \030\036\032\017\n\036 \031)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\005 \022\024\020\024\030)Tj 0 Tw (-)Tj 0.136 Tw T* (\021\t \002\024\035\034\027\t\b \031\r\036\035\017\004\017\r\026\036\021\ \023\030\024\007\024\035\032\017\021\036\035\034\027\024\f\021\034 \032\ \017\027\017, )Tj 0.261 Tw T* [(\024\007\027\026\022\024, \036\201 )0.5(\220\235\235\036\022\021\017\r\027\024\f\021\034 )0.5(\n\036\027\034\001\036, )0.5(\004\036\n \031)]TJ /Span<>> BDC ( )Tj EMC (\002\024\035\034\027\t\b )Tj -0.005 Tw T* (\030\026\022\024\n \024\002\024\007\024\004\027\024\005 \022\017\001\022\ \017. \203\036\024\002\b\024\007\017\n\024\f\021\034 \023\030\024\r\036\007\ \036\027\017\016 )Tj 0.317 Tw T* (\b\017\n\017\024\035\031\004\036\r\024\005 \021\036\030\026\023\017\017 \ \r)Tj /Span<>> BDC ( )Tj EMC (\027\036\024\026\007\255\033\r\026\027\021\027\024\n \030\036\032\017\n\036\ )Tj -0.001 Tw T* (\031)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\034\027\t\b \030\026\022\024\n \023\030\016\n\024\005 \022\017\ \001\022\017 \f\022\026\t\r\026\036\021\f\016 \027\026)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\036)Tj 0 Tw (-)Tj 0.097 Tw T* (\027\024\f\017\n\024\f\021\017 \017)Tj /Span<>> BDC ( )Tj EMC (\022\024\n\023\035\026\036\027\021\027\024\f\021\017 \026\007\255\033\r\026\ \027\021\027\024\005 \b\017\n\017\024\021\036)Tj 0 Tw (-)Tj 0.084 Tw T* (\030\026\023\017\017, \r)Tj /Span<>> BDC ( )Tj EMC (\f\r\016\017 \f)Tj /Span<>> BDC ( )Tj EMC (\004\036\n \026\023\035\026\027\017\030\024\r\026\027\027\t\005 \022\031\ \030\f \f\017\f\021\036\n)Tj 0 Tw (-)Tj -0.025 Tw T* (\027\024\020\024 \035\036\004\036\027\017\016 \023\024\035\031\004\026\036\ \021 \027\036 \002\024\035\036\036 70% \023\026\006\017\036\027\021\024\r\ [4,5]. )Tj 0.02 Tw T* (\215\036\030\f\023\036\022\021\017\r\027\t\n \016\r\035\016\036\021\f\016\ \027\026\027\026\004\036\027\017\036 \022\024\027\f\024\035\017\007\017\ \030\031\033)Tj 0 Tw (-)Tj 0.092 Tw T* [(\013\036\005 )0.5(\017\035\017 )0.5(\017\027\007\031\022\006\017\024\027\027\024\005 )0.5(\b\017\n\017\024\021\036\030\026\023\017\017 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 17.165 0 Td (\007\024\023\024\035\027\036\027\017\036 )Tj -0.005 Tw -17.165 -1.218 Td (\022)Tj /Span<>> BDC ( )Tj EMC [(\f\021\026\027\007\026\030\021\027\024\005 )0.5(\216\214\230 \r)]TJ /Span<>> BDC ( )Tj EMC [(\030\036\032\017\n\036 )0.5(\021\024\021\026\035\034\027\024\005 )0.5(\027\036\024\026\007\255\033\r\026\027\021)]TJ 0 Tw (-)Tj 0.29 Tw T* (\027\024\005 \021\036\030\026\023\017\017 \(\230\203\230\). \215\024)Tj /Span<>> BDC ( )Tj EMC (\007\026\027\027\t\n \035\017\021\036\030\026\021\031\030\t, \021\026\022\ \024\005 )Tj 0.038 Tw 23.244 29.227 Td (\023\024\007\b\024\007 \027\036 \021\024\035\034\022\024 \f\024\023\030\024\ \r\024\032\007\026\036\021\f\016 \035\031\004\001\036\005 \023\036\030\036\ \027\024\f\017)Tj 0 Tw (-)Tj 0.132 Tw T* (\n\024\f\021\034\033, \027\024 \017)Tj /Span<>> BDC ( )Tj EMC (\023\024\r\t\001\026\036\021 \001\026\027\f \027\026)Tj /Span<>> BDC ( )Tj EMC (\023\024\035\031\004\036\027\017\036 \023\024\035\027\024\020\024 )Tj 0.595 Tw T* (\023\026\021\024\n\024\030\235\024\035\024\020\017\004\036\f\022\024\020\ \024 \024\021\r\036\021\026, \022\024\021\024\030\t\005 \016\r\035\016\036\ \021\f\016 )Tj 0.12 Tw T* (\002\035\026\020\024\023\030\017\016\021\027\t\n \023\030\024\020\027\024\ \f\021\017\004\036\f\022\017\n \023\030\017\027\026\022\024\n \r)Tj /Span<>> BDC ( )Tj EMC (\024\021\027\024)Tj 0 Tw (-)Tj -0.005 Tw T* [(\001\036\027\017\017 )0.5(\024\002\013\036\005 )0.6(\r\t\032\017\r\026\036\n\024\f\021\017 )0.5(\023\026\006\017\036\027\021\024\r )0.6([6,7]. )0.5(\212\030\031\020\017\n )]TJ 0.031 Tw T* (\023\030\036\017\n\031\013\036\f\021\r\024\n \230\203\230 \016\r\035\016\ \036\021\f\016 \031\r\036\035\017\004\036\027\017\036 \023\030\024\023\024\ \030\006\017\017 )Tj 0.288 Tw T* (\002\024\035\034\027\t\b \f)Tj /Span<>> BDC ( )Tj EMC (\023\024\035\027\t\n \022\035\017\027\017\004\036\f\022\017\n \030\036\020\ \030\036\f\f\024\n \024\023\031\b\024)Tj 0 Tw (-)Tj 0.462 Tw T* (\035\017, \022\024\021\024\030\t\n \r\024\n\024\032\027\024 \023\030\036\ \007\035\024\032\017\021\034 \024\030\020\026\027\024\f\024\b\030\026)Tj 0 Tw (-)Tj 0.263 Tw T* (\027\016\033\013\036\036 \035\036\004\036\027\017\036 \r)Tj /Span<>> BDC ( )Tj EMC (\030\026\n\022\026\b \f\021\030\026\021\036\020\017\017 \253\027\026\002\ \035\033\007\036\027\017\016 )Tj 0 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\r\t\032\017\007\026\027\017\016\273.)Tj 0.305 Tw T* (\212\026\027\027\026\016 \f\021\026\021\034\016 \023\024\f\r\016\013\036\ \027\026 \030\036\031\035\034\021\026\021\026\n \030\026\027\007\024\n\017\ \017)Tj 0 Tw (-)Tj 0.242 Tw T* (\030\024\r\026\027\027\024\020\024 \017\f\f\035\036\007\024\r\026\027\017\ \016, \006\036\035\034\033 \022\024\021\024\030\024\020\024 \016\r\035\016\ \036\021\f\016 )Tj 0.338 Tw T* (\026\027\026\035\017 \220\235\235\036\022\021\017\r\027\024\f\021\017 \021\ \024\021\026\035\034\027\024\005 \027\036\024\026\007\255\033\r\026\027\021\ \027\024\005 )Tj 0 Tw T* (\021\036\030\026\023\017\017 \r)Tj /Span<>> BDC ( )Tj EMC (\035\036\004\036\027\017\017 \002\024\035\034\027\t\b \030\026\022\024\n\ \023\030\016\n\024\005 \022\017\001\022\017.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 0.01 Tc 0.018 Tw 14 0 0 14 275.0305 176.8199 Tm [(\f\026\017\031\034\022\024\232)5( \031)5(\016)-18.3(\240\034)-31(\024)35(\037\226\232)]TJ 0 0 0 1 k /GS1 gs /T1_3 1 Tf 0 Tc 0.089 Tw 10 0 0 10 274.9606 152.4639 Tm [(\200 \023\036\030\017\024\007 )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC [(\024\022\021\016\002\030\016 )0.5(2020 \020. \023\024)]TJ /Span<>> BDC ( )Tj EMC [(\017\033\027\034 )0.5(2023 \020. )0.5(\027\026)]TJ /Span<>> BDC ( )Tj EMC (\002\026\036 )Tj 0.221 Tw T* (\205\206\207\211 \253\203\204\222\037 \022\024\035\024\023\030\024\022\021\ \024\035\024\020\017\017 \017\n\036\027\017 \202.\203. \217\t\032\017\b\273\ )Tj 0.172 Tw T* (\204\017\027\007\030\026\r\026 \217\024\f\f\017\017 \023\030\024\r\036\007\ \036\027\024 \023\030\024\f\023\036\022\021\017\r\027\024\036, \f\030\026\ \r)Tj 0 Tw (-)Tj 1.35 Tw T* (\027\017\021\036\035\034\027\024\036, \030\026\027\007\024\n\017\017\030\ \024\r\026\027\027\024\036 \017\f\f\035\036\007\024\r\026\027\017\036. )Tj 0.8 Tw T* (\206\017\023\024\021\036\026 \017\f\f\035\036\007\024\r\026\027\017\016\ : \022\024\n\002\017\027\026\006\017\016 \023\030\024\035\024\027\020\017\ )Tj 0 Tw (-)Tj 0.321 Tw T* (\030\024\r\026\027\027\024\005 \b\017\n\017\024\035\031\004\036\r\024\005\ \021\036\030\026\023\017\017 \f)Tj /Span<>> BDC ( )Tj EMC (\022\031\030\f\024\n \022\024\027\f\024)Tj 0 Tw (-)Tj 0.541 Tw T* (\035\017\007\017\030\031\033\013\036\005 \b\017\n\017\024\021\036\030\026\ \023\017\017 \r)Tj /Span<>> BDC ( )Tj EMC (\030\036\032\017\n\036 \021\024\021\026\035\034\027\024\005 )Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 0 Tw 7.5 0 0 7.5 42.5197 759.8869 Tm [(\021\032)50(\b)42(\032\231\027 \213\036)30.1(\005\t\033)30(\b)]TJ 52.896 0 Td (LEADING ARTICLE)Tj /T1_5 1 Tf 25 0 0 25 511.152 56.0378 Tm (11)Tj ET endstream endobj 2453 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 2454 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 2455 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 2456 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 2457 0 obj <>/ExtGState<>/Font<>/ProcSet[/PDF/Text]/Properties<>/Shading<>/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 2595 0 obj [2598 0 R] endobj 2596 0 obj <>stream q /GS0 gs /Fm0 Do Q 0 0 0 1 K 1 j 1 J [0 2.997]0 d /GS1 gs q 1 0 0 1 74.3631 273.0103 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 71.3661 273.0103 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q [0 2.997]0 d q 1 0 0 1 74.3631 235.8025 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 71.3661 235.8025 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q BT 0 0 0 1 k /T1_0 1 Tf 10 0 0 10 70.8661 724.8299 Tm (https://doi.org/10.33878/2073-7556-2024-23-1-10-20)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0.023 Tw 19 0 0 19 125.5518 695.3259 Tm [(\235\225\225\016\n)-10(\026\220\r\001\025\006)-9.9(\026\216 \026)11(\025\026)11(\013\007\216\001\025\203 \001\016\025\013\201\230\212\r\013\001\026\001\025\ \203 )]TJ -1.57 -1.105 Td [(\026)11(\016\002\013\221\220\220 \r\022)-23.2(\007\016\017\016\001\220\220 \002\013\n\013 \221\002\205\024\025\203 \n\220\ \n\220. \033\016\222)21.1(\215\007\216)21(\026)11(\013\026\020 )]TJ 3.134 -1.105 Td [(\002\013\001\201\025\024\220\222\220\002\025\r\013\001\001\025\202)10.1(\025 \220\006\006)-10(\007\016\201\025\r\013\001\220\205)]TJ 0 0 0 1 k /GS1 gs 0 Tw 14 0 0 14 70.8661 628.822 Tm [(\021\020\017\016\r\022)-23.2(\021.\030.)]TJ 8.162 0 0 8.162 136.1933 633.484 Tm (1)Tj 0.023 Tw 14 0 0 14 140.8293 628.822 Tm [(, \033\020\f\013\n)10(\025\r\022)-23.2(\t.\031)72(.)]TJ 0 Tw 8.162 0 0 8.162 220.8606 633.484 Tm (1)Tj 0.023 Tw 14 0 0 14 225.4966 628.822 Tm [(, \b)-21(\007\016\n\006\016\016\r\022)-23.2(\005.\004.)]TJ -0.069 Tc 0.069 Tw 8.162 0 0 8.162 318.0571 633.484 Tm [(1,)-69(2)]TJ 0 Tc 0.023 Tw 14 0 0 14 329.3777 628.822 Tm [(, \003\016\002\001\020\025\r\022)-23.2(\021.\004.)]TJ 0 Tw 8.162 0 0 8.162 425.2004 633.484 Tm (1)Tj 14 0 0 14 429.8364 628.822 Tm (, )Tj -25.641 -1.143 Td [(\034\025\001\025\024\013\002\016\001\n)10.1(\025\022)-23.3(\b)-31(.\b)-31(.)]TJ 8.162 0 0 8.162 181.6927 617.484 Tm (1)Tj 5.83 0 0 5.83 70.8661 598.4827 Tm (1)Tj 0.023 Tw 10 0 0 10 74.1775 595.1527 Tm [(\210\031\214)42(\240 \253\213\005\030\226 \n)10(\025\007\025\221\002\025\n)-9.9(\026)11(\025\007\025\202\220\220 \220\024\016\001\220 \b)-30.9(.\213.\022)-23.3(\033\020\217\220\207\273 \005\220\001\222\201\002\013\r\013 \033\025\006\ \006\220\220 \(\215\007.\022)-23.3(\021\013\007\205\024\013 \b)-20.9(\201\220\007\205, \201.\022)-23.3(2, \202)62.1(.\022)-23.3(\005\025\006\n\r\013, )]TJ -0.331 -1.2 Td [(1)125(23)58(423, \033\025\006\006\220\205\))]TJ 0 Tw ( )Tj 5.83 0 0 5.83 70.8661 574.4827 Tm (2)Tj 0.023 Tw 10 0 0 10 74.1775 571.1527 Tm [(\210\031\214)21(\036)20(\240 \255\034\036 \033)21(\005\b\213\034\036 \005\220\001\222\201\002\013\r\013 \033\025\006\006\220\ \220 \(\215\007.\022)-23.2(\214\013\002\002\220\n\013\201\001\013\205, \201.\022)-23.3(2/1)69(, \006)-10(\026\002)-31(.\022)-23.3(1)69(, \202)62(.\022)-23.2(\005\025\006\n\r\013, 1)125(2)23(5)23(99)35(3, \033\025\006\006\220\205\))]TJ /T1_0 1 Tf 0.036 Tw 9 0 0 9 119.0551 552.6488 Tm (\037\036\035\034: \033\032\031\030\027\026\032\025\024\031\023\022\021\020\ \017 \026\021\026\023\025\016 \r\f\f\031\013\024\025\027\021\n\t\024\025\ \024\n\024\026\023\022\021\n\017 \021\031\n\026\030\b\007\027\026\021\024\ \021\n\017 \024\031\032\026\033\025\025 \027)Tj /Span<>> BDC ( )Tj EMC (\023\031\006\031\021\025\025 \005\n\023\022\021\020\004 )Tj 0.023 Tw 0 -1.111 TD (\032\026\013\n\003 \033\032\002\003\n\017 \013\025\001\013\025.)Tj -0.025 Tw T* (\201\037\215\036\217\220\235 \215)Tj /Span<>> BDC ( )Tj EMC (\240\036\220\255\200\235: \033\n\t\023\031 \033\n\030\033\025\t\026\021\025\ \002 \030\n\005\032\n\027\n\023\022\021\n\202\n \025\021\f\n\032\003\025\ \032\n\027\026\021\021\n\202\n \t\n\202\023\026\t\025\002 \033\026\203\025\ \031\021\024\020 \t)Tj /Span<>> BDC ( )Tj EMC (\202\025\t\024\n\023\n\202\025)Tj 0 Tw (-)Tj -0.027 Tw T* (\006\031\t\013\025 \033\n\030\024\027\031\032\204\030\031\021\021\n\017 \ \026\030\031\021\n\013\026\032\203\025\021\n\003\n\017 \033\032\002\003\n\ \017 \013\025\001\013\025 \032\026\021\030\n\003\025\016\025\032\n\027\026\ \023\025\t\022 \027)Tj /Span<>> BDC ( )Tj EMC (\030\027\031 \202\032\205\033\033\020: \027)Tj /Span<>> BDC ( )Tj EMC (\202\032\205\033\033\031 \220\217\220 \033\n\t\023\031 )Tj 0.096 Tw T* (\021\031\n\026\030\b\007\027\026\021\024\021\n\017 \206\035\220 \207\255\ \200 50\22654)Tj /Span<>> BDC ( )Tj EMC (\210\032 \t)Tj /Span<>> BDC ( )Tj EMC (\013\026\033\031\203\025\024\026\005\025\021\n\003 \033\032\n\027\n\030\025\ \023\025 3 \013\205\032\t\026 \013\n\021\t\n\023\025\030\025\032\205\007\ \211\031\017 \004\025\003\025\n\024\031\032\026\033\025\025 )Tj 0.035 Tw 0 -1.111 TD (\033\n)Tj /Span<>> BDC ( )Tj EMC (\t\004\031\003\031 xelox, \027)Tj /Span<>> BDC ( )Tj EMC (\202\032\205\033\033\031 \206\035\220 \033\032\n\027\n\030\025\023\025 \021\ \031\n\026\030\b\007\027\026\021\024\021\205\007 \206\035\220 \207\255\200\ 50\22654)Tj /Span<>> BDC ( )Tj EMC (\210\032 \t)Tj /Span<>> BDC ( )Tj EMC (\013\026\033\031\203\025\024\026\005\025\021\n\003. \n)Tj /Span<>> BDC ( )Tj EMC (\n\013\n\021\006\026\021\025\025 )Tj 0.108 Tw 0 -1.111 TD (\023\031\006\031\021\025\002 \033\032\n\027\n\030\025\023\025 \013\n\021\ \024\032\n\023\022\021\n\031 \n\005\t\023\031\030\n\027\026\021\025\031 \ \t)Tj /Span<>> BDC ( )Tj EMC (\n\203\031\021\013\n\017 \032\031\202\032\031\t\t\026 \n\033\205\004\n\023\ \025 \033\n)Tj /Span<>> BDC ( )Tj EMC (\030\026\021\021\020\003 \240\212\220 \t)Tj /Span<>> BDC ( )Tj EMC (\033\032\025\003\031\021\031\021\025\031\003 )Tj 0.079 Tw T* [(\001\013\026\023\020 )0.6(mrTRG. )0.6(\213\n\023\022\021\020\003 )0.6(\t)]TJ /Span<>> BDC ( )Tj EMC 10.821 0 Td [(\033\n\023\021\020\003 )0.6(\013\023\025\021\025\006\031\t\013\025\003 )0.6(\n\024\027\031\024\n\003, )0.6(\013\n\024\n\032\020\031 )0.6(\n\024\013\026\016\026\023\025\t\022 )0.5(\n\024 )0.6(\004\025\032\205\032\202\025\006\031\t\013\n\202\n )0.5(\023\031\006\031\021\025\002, )]TJ 0.096 Tw -10.821 -1.111 Td [(\005\020\023\n )0.5(\033\032\031\030\023\n\204\031\021\n )0.5(\030\025\021\026\003\025\006\031\t\013\n\031 )0.6(\021\026\005\023\007\030\031\021\025\031 )0.5(\027)]TJ /Span<>> BDC ( )Tj EMC [(\032\026\003\013\026\004 )0.5(\t\024\032\026\024\031\202\025\025 )0.5(\253\021\026\005\023\007\030\031\021\025\002 )0.5(\025)]TJ /Span<>> BDC ( )Tj EMC 34.734 0 Td (\027\020\204\025\030\026\021\025\002\273. \214)Tj /Span<>> BDC ( )Tj EMC 6.647 0 Td (\n\033\031\032\025\032\n)Tj 0 Tw (-)Tj 0.039 Tw -41.381 -1.111 Td (\027\026\021\021\020\004 \005\n\023\022\021\020\004 \r\f\f\031\013\024 \n\ \024 \021\031\n\026\030\b\007\027\026\021\024\021\n\017 \024\031\032\026\ \033\025\025 \n\203\031\021\025\027\026\023\025 \033\n)Tj /Span<>> BDC ( )Tj EMC (\032\031\016\205\023\022\024\026\024\026\003 \033\026\024\n\003\n\032\f\n\ \023\n\202\025\006\031\t\013\n\202\n )Tj 0.004 Tw T* (\025\t\t\023\031\030\n\027\026\021\025\002 \t)Tj /Span<>> BDC ( )Tj EMC (\033\032\025\003\031\021\031\021\025\031\003 \001\013\026\023\020 Ryan. \ \031\032\027\025\006\021\026\002 \024\n\006\013\026 \025\t\t\023\031\030\ \n\027\026\021\025\002: \006\026\t\024\n\024\026 \033\n\023\021\020\004 \ \n\024\027\031\024\n\027 \n\033\205\004\n)Tj 0 Tw (-)Tj 0.055 Tw T* (\023\025 \(\013\023\025\021\025\006\031\t\013\025\004 \025)Tj /Span<>> BDC ( )Tj EMC (\033\026\024\n\003\n\032\f\n\023\n\202\025\006\031\t\013\025\004\). \216\ \024\n\032\025\006\021\020\031 \024\n\006\013\025 \025\t\t\023\031\030\n\ \027\026\021\025\002: \006\026\t\024\n\024\026 \025)Tj /Span<>> BDC ( )Tj EMC (\t\024\032\205\013\024\205\032\026 \025\021\024\032\026- )Tj 0.151 Tw T* (\025)Tj /Span<>> BDC ( )Tj EMC (\033\n\t\023\031\n\033\031\032\026\203\025\n\021\021\020\004 \n\t\023\n\204\ \021\031\021\025\017, \006\026\t\024\n\024\026 \n\t\023\n\204\021\031\021\ \025\017 3\2264)Tj /Span<>> BDC ( )Tj EMC (\t\024\031\033\031\021\025 \023\205\006\031\027\n\017 \024\031\032\026\033\ \025\025 \025)Tj /Span<>> BDC ( )Tj EMC (\004\025\003\025\n\024\031\032\026\033\025\025, )Tj 0.023 Tw T* (\006\026\t\024\n\024\026 R0-\032\031\016\031\013\203\025\017. \215\t\t\023\ \031\030\n\027\026\021\025\031 \016\026\032\031\202\025\t\024\032\025\032\ \n\027\026\021\n \021\026)Tj /Span<>> BDC ( )Tj EMC (\033\n\032\024\026\023\031 ClinicalTrials.gov \(NCT04747951\).)Tj 0.115 Tw 0 -1.111 TD (\212\036\221\214\035\034\220\201\220\235: \016\026)Tj /Span<>> BDC ( )Tj EMC (\033\031\032\025\n\030 \t)Tj /Span<>> BDC ( )Tj EMC (\n\013\024\002\005\032\002 2020)Tj /Span<>> BDC ( )Tj EMC (\227 \033\n)Tj /Span<>> BDC ( )Tj EMC (\n\013\024\002\005\032\022 2023)Tj /Span<>> BDC ( )Tj EMC (\202\202. \027)Tj /Span<>> BDC ( )Tj EMC (\032\026\021\030\n\003\025\016\025\032\n\027\026\021\021\n\031 \025\t\t\023\ \031\030\n\027\026\021\025\031 \005\020\023\n )Tj 0.012 Tw 0 -1.111 TD (\027\013\023\007\006\031\021\n 183 \033\026\203\025\031\021\024\026: 91)Tj /Span<>> BDC ( )Tj EMC (\227 \027)Tj /Span<>> BDC ( )Tj EMC (\202\032\205\033\033\031 \220\217\220 \025)Tj /Span<>> BDC ( )Tj EMC (92)Tj /Span<>> BDC ( )Tj EMC (\227 \027)Tj /Span<>> BDC ( )Tj EMC (\202\032\205\033\033\031 \206\035\220. \216)Tj /Span<>> BDC ( )Tj EMC (\026\021\026\023\025\016 \027\013\023\007\006\031\021\n 60 \033\026\203\025\ \031\021\024\n\027 \027)Tj /Span<>> BDC ( )Tj EMC (\202\032\205\033\033\031 )Tj 0.084 Tw T* (\220\217\220 \025)Tj /Span<>> BDC ( )Tj EMC (71 \033\026\203\025\031\021\024)Tj /Span<>> BDC ( )Tj EMC (\227 \027)Tj /Span<>> BDC ( )Tj EMC (\202\032\205\033\033\031 \206\035\220. \032\025)Tj /Span<>> BDC ( )Tj EMC (\003\031\030\025\026\021\031 \(Q1,Q3\) \027\032\031\003\031\021\025 \021\ \026\005\023\007\030\031\021\025\002 24 \(14; 28\) \003\031\t\002\203\031\ \027 \033\n\023\021\020\017 )Tj -0.003 Tw T* [(\013\023\025\021\025\006\031\t\013\025\017 \n\024\027\031\024 \t\n\004\032\ \026\021\002\031\024\t\002 )0.5(\205)]TJ /Span<>> BDC ( )Tj EMC (23% \(14/60\) \033\026\203\025\031\021\024\n\027 \027)Tj /Span<>> BDC ( )Tj EMC (\202\032\205\033\033\031 \220\217\220 \025)Tj /Span<>> BDC ( )Tj EMC (\205 7% \(5/71\) \033\026\203\025\031\021\024\n\027)Tj /Span<>> BDC ( )Tj EMC (\227 \027)Tj /Span<>> BDC ( )Tj EMC (\202\032\205\033)Tj 0 Tw (-)Tj 0.054 Tw T* (\033\031 \206\035\220 \(\032)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,008\). \214)Tj /Span<>> BDC ( )Tj EMC (\n\033\031\032\025\032\n\027\026\021\021\020\004 \005\n\023\022\021\020\004\ \006\026\t\024\n\024\026 \033\n\023\021\n\202\n \033\026\024\n\003\n\032\ \f\n\023\n\202\025\006\031\t\013\n\202\n \n\024\027\031\024\026 \t\n\t\024\ \026\027\025\023\026 )Tj 0.124 Tw T* (20% \(9/45\))Tj /Span<>> BDC ( )Tj EMC (\227 \027)Tj /Span<>> BDC ( )Tj EMC (\202\032\205\033\033\031 \220\217\220 \025)Tj /Span<>> BDC ( )Tj EMC (8% \(5/66\))Tj /Span<>> BDC ( )Tj EMC (\227 \027)Tj /Span<>> BDC ( )Tj EMC (\202\032\205\033\033\031 \206\035\220 \(\032)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,05\). \n)Tj /Span<>> BDC ( )Tj EMC (\006\026\t\024\n\024\031 \032\026\016\027\025\024\025\002 \024\n\013\t\025\ \006\031\t\013\025\004 )Tj 0.095 Tw T* (\032\031\026\013\203\025\017 3\2264)Tj /Span<>> BDC ( )Tj EMC (\t\024\031\033\031\021\025, \006\026\t\024\n\024\031 \025)Tj /Span<>> BDC ( )Tj EMC (\t\024\032\205\013\024\205\032\031 \025\021\024\032\026- \025)Tj /Span<>> BDC ( )Tj EMC (\033\n\t\023\031\n\033\031\032\026\203\025\n\021\021\020\004 \n\t\023\n\204\ \021\031\021\025\017, \026)Tj /Span<>> BDC ( )Tj EMC (\024\026\013\204\031 \006\026\t\024\n\024\031 )Tj 0.023 Tw T* (R0-\032\031\016\031\013\203\025\017 \202\032\205\033\033\020 \t\024\026\024\ \025\t\024\025\006\031\t\013\025 \016\021\026\006\025\003\n \021\031 \032\ \026\016\023\025\006\026\023\025\t\022.)Tj 0.003 Tc 0.35 Tw T* [(\221\201\222\035\223\224\036\217\215\036: \033\032\031\030\027\026\032\025\ \024\031\023\022\021\020\031 \032\031\016\205\023\022\024\026\024\020 \032\ \026\021\030\n\003\025\016\025\032\n\027\026\021\021\n\202\n \025\t\t\023\ \031\030\n\027\026\021\025\002 \033\032\n\030\031\003\n\021\t\024\032\025\ \032\n\027\026\023\025)3( )]TJ 0 Tc 0.134 Tw 0 -1.111 TD (\r\f\f\031\013\024\025\027\021\n\t\024\022 \025)Tj /Span<>> BDC ( )Tj EMC (\005\031\016\n\033\026\t\021\n\t\024\022 \024\n\024\026\023\022\021\n\017\ \021\031\n\026\030\b\007\027\026\021\024\021\n\017 \024\031\032\026\033\ \025\025 \027)Tj /Span<>> BDC ( )Tj EMC (\023\031\006\031\021\025\025 \005\n\023\022\021\020\004 \032\026\013\n\003\ \033\032\002\003\n\017 )Tj 0 Tw 0 -1.111 TD (\013\025\001\013\025.)Tj /T1_2 1 Tf 0.01 Tc 0.018 Tw 8 0 0 8 70.906 297.3795 Tm [(\037\036\035\034\033\032\031\033)5( \030\036\027\032\026:)]TJ /T1_0 1 Tf 0 Tc 0.023 Tw 8.493 0 Td ( \032\026\013 \033\032\002\003\n\017 \013\025\001\013\025, \021\031\n\026\ \030\b\007\027\026\021\024\021\026\002 \024\031\032\026\033\025\002, \024\ \n\024\026\023\022\021\026\002 \021\031\n\026\030\b\007\027\026\021\024\021\ \026\002 \024\031\032\026\033\025\002)Tj /T1_2 1 Tf 0.01 Tc 0.018 Tw -8.493 -1.909 Td [(\037\027\025\024\036\023\037\022)5( \023\025\022\033\021\033\030\027\032:)]TJ /T1_0 1 Tf 0 Tc 0.023 Tw 10.401 0 Td ( \026\027\024\n\032\020 \016\026\002\027\023\002\007\024 \n\005 \n\024\t\ \205\024\t\024\027\025\025 \013\n\021\f\023\025\013\024\026 \025\021\024\ \031\032\031\t\n\027)Tj /T1_2 1 Tf 0.033 Tc 0.066 Tw -10.401 -2.617 Td [(\020\036\017)4.7( \016\023\022\023\021\027\032\026\025\023\017:)]TJ /T1_3 1 Tf 0.023 Tc 0.071 Tw 9.239 0 Td ( \221\t\004\036\r)Tj /Span<>> BDC ( )Tj EMC (\221.\222., \217\t\002\026\022\024\r)Tj /Span<>> BDC ( )Tj EMC (\213.\206., \202\035\036\022\f\036\036\r)Tj /Span<>> BDC ( )Tj EMC (\204.\200., \223\036\030\027\t\001\024\r)Tj /Span<>> BDC ( )Tj EMC (\221.\200., \215\024\027\024\n\026\030\036\027\022\024)Tj /Span<>> BDC ( )Tj EMC (\202.\202. \224\235\235\036\022\021\017\r\027\024\f\021\034 \021\024\021\ \026\035\034\027\024\005 \027\036\024)Tj 0 Tc 0 Tw (-)Tj 0.023 Tc 0.12 Tw -9.244 -1.2 Td (\026\007\255\033\r\026\027\021\027\024\005 \021\036\030\026\023\017\017 \ \r)Tj /Span<>> BDC ( )Tj EMC (\035\036\004\036\027\017\017 \030\026\022\026 \023\030\016\n\024\005 \022\ \017\001\022\017. \217\036\031\035\034\021\026\021\t \030\026\027\007\024\ \n\017\017\030\024\r\026\027\027\024\020\024 \017\f\f\035\036\007\024\r\ \026\027\017\016. )Tj /T1_0 1 Tf -0.023 Tw (\222\n\023\n\033\032\n\013\024\n\023\n\202\025\002.)Tj /T1_3 1 Tf 0.12 Tw [( 2024;)23( )]TJ 0.024 Tw 0 -1.2 TD (\021.)Tj /Span<>> BDC ( )Tj EMC (23, \225)Tj /Span<>> BDC ( )Tj EMC [(1, )0.5(\f.)]TJ /Span<>> BDC ( )Tj EMC (10\22620. https://doi.org/10.33878/2073-7556-2024-23-1-10-20)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0 Tc 0.023 Tw 18 0 0 18 104.0957 209.6332 Tm [(Ef)-31(fectiv)12.1(eness of th)11.1(e total neoadju)10(v)10(ant th)11(er)21(apy in r)31.1(ectal )]TJ 1.158 -1.167 Td [(cancer tr)31.1(eatment. Results of th)11(e r)21(andomiz)10(ed trial)]TJ 0 0 0 1 k /GS1 gs 0 Tw 14 0 0 14 70.8661 164.1292 Tm [(Ser)31(gey\022)-23.3(I.\022)-23.2(Sy)10(ch)11(e)11(v)]TJ 8.162 0 0 8.162 163.5676 168.7912 Tm (1)Tj 0.023 Tw 14 0 0 14 168.2036 164.1292 Tm [(, Ev)10(geny\022)-23.2(G.\022)-23.3(R)20(ybak)11(ov)]TJ 0 Tw 8.162 0 0 8.162 286.7949 168.7912 Tm (1)Tj 0.023 Tw 14 0 0 14 291.4309 164.1292 Tm [(, Mikhail\022)-23.3(V)62(.\022)-23.3(Alek)11.1(see)11(v)]TJ -0.069 Tc 0.069 Tw 8.162 0 0 8.162 409.125 168.7912 Tm [(1,)-69(2)]TJ 0 Tc 0 Tw 14 0 0 14 420.4456 164.1292 Tm (, )Tj -24.97 -1.143 Td [(Stanislav\022)-23.2(V)62(.\022)-23.3(Ch)11(erny)10.1(sh)11(ov)]TJ 8.162 0 0 8.162 204.3763 152.7912 Tm (1)Tj 0.023 Tw 14 0 0 14 209.0122 148.1292 Tm [(, Alek)11(sey\022)-23.2(A)-31(.\022)-23.3(P)10(onomar)31(enk)11.1(o)]TJ 0 Tw 8.162 0 0 8.162 357.6744 152.7912 Tm (1)Tj 5.83 0 0 5.83 70.8661 133.79 Tm (1)Tj 0.023 Tw 10 0 0 10 74.1775 130.46 Tm [(R)20(y)21(zhikh National Medical Resear)31(ch Center of Colopr)20.1(octology \(Saly)21(ama Adily)21(a\022)-23.3(st., 2, Moscow)22(, 1)125(23)58(423, Russia\))]TJ 0 Tw ( )Tj 5.83 0 0 5.83 70.8661 121.79 Tm (2)Tj 0.023 Tw 10 0 0 10 74.1775 118.46 Tm [(Russian Medical Academ)21.1(y of Continuous Pr)20(ofessional Education \(Barrikadnay)21.1(a\022)-23.3(st., 2/1-1)69(, Moscow)22(, 1)125(2)23(5)23(99)35(3, )]TJ 0 Tw -0.331 -1.2 Td (Russia\))Tj /T1_0 1 Tf 0.023 Tw 9 0 0 9 119.0551 87.9561 Tm [(AIM: to assess ef)-40(fectiv)13(eness of to)13(tal neoadjuv)16(ant therap)12(y \(TNT\) for patients with rectal carcinoma.)]TJ ET 1 0.68 0 0.12 k /GS0 gs q 1 0 0 1 70.8661 561.1533 cm 0 0 m 0 0 l 0 -11.339 l 42.52 -11.339 l 42.52 0 l h f Q BT 0 0 0 0 k /T1_2 1 Tf 0 Tw 9 0 0 9 76.0071 552.226 Tm (\021\033\r\035\f\033)Tj ET 1 0.68 0 0.12 k q 1 0 0 1 70.8661 96.4604 cm 0 0 m 0 0 l 0 -11.339 l 42.52 -11.339 l 42.52 0 l h f Q BT 0 0 0 0 k /T1_2 1 Tf 9 0 0 9 73.5728 87.5332 Tm (ABSTRACT)Tj ET q 0 0 566.929 793.701 re W n BT 1 0.68 0 0.12 k /T1_4 1 Tf 0.01 Tc 0.018 Tw 14 0 0 14 70.936 837.3533 Tm [(\017)-32(\r)41(\037)31(\r\231\224)5( \t\004\213\207\n)43(\037)]TJ /T1_1 1 Tf 0 -1.605 TD [(LEADING)5( ARTICLE)]TJ ET Q BT 1 0.68 0 0.12 k /T1_1 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\021\032)50(\b)42(\032\231\027 \213\036)30.1(\005\t\033)30(\b)]TJ 52.896 0 Td (LEADING ARTICLE)Tj -52.896 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 23, \023\0221)69(, 202)69(4)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 23, \023\0221)69(, 202)69(4)]TJ /T1_5 1 Tf 25 0 0 25 27.2651 56.0378 Tm (10)Tj ET q 0 g 0 G 0 j 0 J /Fm1 Do Q 0 0 0 0 k 396.85 725.67 59.155 11.338 re f /PlacedPDF /MC0 BDC q 397.481 736.808 m 397.242 736.808 397.049 736.616 397.049 736.376 c 397.049 736.376 l 397.049 726.285 l 397.049 726.045 397.242 725.853 397.481 725.853 c 397.481 725.853 l 455.382 725.853 l 455.62 725.853 455.815 726.045 455.815 726.285 c 455.815 726.285 l 455.815 736.376 l 455.815 736.616 455.62 736.808 455.382 736.808 c 455.382 736.808 l h W n q 0 g -0.0000005 -10.9560913 -10.9560913 0.0000005 426.4320445 736.8086309 cm BX /Sh0 sh EX Q Q q 396.85 725.67 59.155 11.337 re W n 0 0 0 0.84 k q 1 0 0 1 413.5634 732.4249 cm 0 0 m -0.025 0.1 -0.063 0.196 -0.112 0.287 c -0.157 0.374 -0.218 0.451 -0.292 0.515 c -0.37 0.582 -0.46 0.632 -0.558 0.664 c -0.669 0.701 -0.786 0.719 -0.903 0.717 c -1.076 0.722 -1.247 0.681 -1.4 0.6 c -1.536 0.526 -1.652 0.42 -1.74 0.292 c -1.83 0.158 -1.895 0.008 -1.934 -0.149 c -2.018 -0.48 -2.018 -0.827 -1.934 -1.158 c -1.896 -1.316 -1.83 -1.466 -1.74 -1.602 c -1.653 -1.731 -1.536 -1.837 -1.4 -1.912 c -1.247 -1.993 -1.076 -2.033 -0.903 -2.029 c -0.774 -2.032 -0.647 -2.006 -0.528 -1.955 c -0.427 -1.906 -0.337 -1.837 -0.263 -1.753 c -0.185 -1.665 -0.124 -1.563 -0.082 -1.453 c -0.034 -1.338 0 -1.218 0.019 -1.094 c 0.635 -1.094 l 0.624 -1.297 0.578 -1.497 0.497 -1.684 c 0.421 -1.857 0.312 -2.015 0.175 -2.146 c 0.039 -2.277 -0.123 -2.379 -0.3 -2.446 c -0.492 -2.519 -0.695 -2.555 -0.9 -2.552 c -1.15 -2.557 -1.397 -2.506 -1.625 -2.404 c -1.829 -2.307 -2.01 -2.169 -2.157 -1.997 c -2.308 -1.821 -2.423 -1.617 -2.497 -1.397 c -2.655 -0.924 -2.655 -0.412 -2.497 0.061 c -2.423 0.281 -2.307 0.485 -2.157 0.661 c -2.01 0.833 -1.829 0.973 -1.625 1.07 c -1.398 1.174 -1.15 1.226 -0.9 1.222 c -0.707 1.223 -0.515 1.196 -0.329 1.14 c -0.159 1.088 0.001 1.006 0.144 0.898 c 0.278 0.793 0.39 0.662 0.473 0.513 c 0.562 0.349 0.615 0.167 0.629 -0.019 c 0 -0.019 l 0 0 l f Q q 1 0 0 1 414.6923 733.5723 cm 0 0 m 0.584 0 l 0.584 -1.328 l 0.662 -1.204 0.771 -1.103 0.9 -1.033 c 1.046 -0.951 1.213 -0.91 1.381 -0.914 c 1.627 -0.9 1.869 -0.979 2.058 -1.137 c 2.234 -1.312 2.325 -1.556 2.305 -1.803 c 2.305 -3.596 l 1.716 -3.596 l 1.716 -1.976 l 1.724 -1.817 1.678 -1.66 1.585 -1.53 c 1.486 -1.43 1.347 -1.379 1.206 -1.392 c 1.114 -1.39 1.024 -1.408 0.94 -1.445 c 0.865 -1.479 0.798 -1.529 0.744 -1.591 c 0.687 -1.656 0.645 -1.73 0.616 -1.812 c 0.586 -1.896 0.571 -1.986 0.571 -2.077 c 0.571 -3.615 l 0 -3.615 l 0 0 l f Q q 1 0 0 1 418.0385 731.1235 cm 0 0 m 0 -0.099 0.014 -0.198 0.043 -0.292 c 0.069 -0.382 0.112 -0.466 0.17 -0.54 c 0.229 -0.611 0.304 -0.669 0.388 -0.709 c 0.486 -0.754 0.594 -0.776 0.702 -0.773 c 0.845 -0.78 0.987 -0.742 1.108 -0.664 c 1.217 -0.582 1.296 -0.468 1.336 -0.337 c 1.881 -0.337 l 1.827 -0.603 1.675 -0.838 1.456 -0.996 c 1.35 -1.073 1.231 -1.131 1.105 -1.169 c 0.971 -1.208 0.831 -1.229 0.691 -1.227 c 0.509 -1.227 0.328 -1.191 0.16 -1.121 c 0.007 -1.063 -0.13 -0.972 -0.244 -0.855 c -0.356 -0.73 -0.44 -0.583 -0.491 -0.422 c -0.548 -0.243 -0.576 -0.056 -0.574 0.133 c -0.575 0.313 -0.545 0.493 -0.486 0.664 c -0.426 0.826 -0.335 0.974 -0.22 1.102 c 0.004 1.375 0.338 1.534 0.691 1.535 c 0.883 1.539 1.072 1.495 1.243 1.408 c 1.402 1.326 1.541 1.209 1.649 1.067 c 1.759 0.922 1.838 0.757 1.883 0.582 c 1.932 0.396 1.945 0.203 1.92 0.013 c 0 0.013 l 0 0 l 1.342 0.377 m 1.335 0.468 1.315 0.557 1.283 0.643 c 1.253 0.724 1.209 0.798 1.153 0.863 c 1.097 0.922 1.03 0.97 0.957 1.004 c 0.874 1.043 0.783 1.063 0.691 1.062 c 0.6 1.062 0.509 1.044 0.425 1.009 c 0.345 0.976 0.273 0.926 0.213 0.863 c 0.153 0.799 0.105 0.724 0.072 0.643 c 0.037 0.559 0.017 0.468 0.014 0.377 c 1.355 0.377 l h f Q q 1 0 0 1 422.1581 731.7051 cm 0 0 m -0.012 0.144 -0.082 0.276 -0.194 0.366 c -0.31 0.452 -0.451 0.495 -0.595 0.489 c -0.675 0.488 -0.755 0.476 -0.831 0.452 c -0.918 0.424 -0.998 0.375 -1.062 0.311 c -1.142 0.229 -1.202 0.131 -1.24 0.024 c -1.29 -0.132 -1.312 -0.296 -1.304 -0.459 c -1.304 -0.569 -1.292 -0.677 -1.267 -0.784 c -1.244 -0.885 -1.202 -0.983 -1.145 -1.07 c -1.09 -1.154 -1.016 -1.224 -0.93 -1.275 c -0.833 -1.33 -0.722 -1.356 -0.611 -1.352 c -0.457 -1.357 -0.307 -1.301 -0.194 -1.195 c -0.078 -1.077 -0.005 -0.922 0.011 -0.757 c 0.587 -0.757 l 0.556 -1.055 0.419 -1.332 0.202 -1.538 c -0.022 -1.721 -0.306 -1.815 -0.595 -1.803 c -0.777 -1.806 -0.958 -1.771 -1.126 -1.7 c -1.293 -1.642 -1.445 -1.547 -1.57 -1.421 c -1.68 -1.297 -1.763 -1.151 -1.814 -0.993 c -1.87 -0.822 -1.898 -0.643 -1.896 -0.462 c -1.898 -0.276 -1.871 -0.091 -1.817 0.087 c -1.766 0.252 -1.682 0.405 -1.57 0.537 c -1.459 0.664 -1.323 0.766 -1.168 0.834 c -0.991 0.914 -0.798 0.955 -0.603 0.954 c -0.457 0.954 -0.311 0.935 -0.17 0.895 c -0.039 0.858 0.084 0.799 0.194 0.72 c 0.302 0.643 0.393 0.543 0.459 0.428 c 0.531 0.298 0.572 0.155 0.582 0.008 c 0 0.008 l 0 0 l f Q q 1 0 0 1 423.2177 733.5723 cm 0 0 m 0.577 0 l 0.577 -2.048 l 1.615 -0.985 l 2.322 -0.985 l 1.323 -1.944 l 2.417 -3.604 l 1.716 -3.604 l 0.919 -2.337 l 0.577 -2.669 l 0.577 -3.604 l 0 -3.604 l h f Q q 1 0 0 1 427.0585 732.5762 cm 0 0 m 0.436 0 l 0.436 0.218 l 0.429 0.352 0.448 0.486 0.488 0.614 c 0.521 0.705 0.577 0.786 0.651 0.85 c 0.717 0.905 0.795 0.943 0.879 0.961 c 0.966 0.979 1.056 0.988 1.145 0.988 c 1.28 0.993 1.416 0.981 1.548 0.954 c 1.548 0.505 l 1.509 0.516 1.469 0.523 1.429 0.528 c 1.379 0.532 1.33 0.532 1.28 0.528 c 1.209 0.53 1.14 0.511 1.081 0.473 c 1.019 0.419 0.987 0.337 0.999 0.255 c 0.999 -0.011 l 1.498 -0.011 l 1.498 -0.441 l 1.009 -0.441 l 1.009 -2.622 l 0.436 -2.622 l 0.436 -0.428 l 0.005 -0.428 l 0.005 0 l 0 0 l f Q q 1 0 0 1 430.1 729.8965 cm 0 0 m -0.191 -0.003 -0.381 0.032 -0.559 0.104 c -0.715 0.167 -0.856 0.264 -0.972 0.388 c -1.091 0.512 -1.181 0.659 -1.238 0.82 c -1.356 1.18 -1.356 1.567 -1.238 1.925 c -1.181 2.087 -1.091 2.234 -0.972 2.358 c -0.856 2.481 -0.715 2.578 -0.559 2.643 c -0.199 2.78 0.198 2.78 0.558 2.643 c 0.714 2.578 0.855 2.481 0.972 2.358 c 1.09 2.234 1.181 2.087 1.237 1.925 c 1.355 1.567 1.355 1.18 1.237 0.82 c 1.181 0.659 1.09 0.512 0.972 0.388 c 0.855 0.266 0.713 0.169 0.558 0.106 c 0.38 0.034 0.191 -0.002 0 0 c 0 0.454 m 0.115 0.451 0.23 0.479 0.332 0.534 c 0.424 0.586 0.502 0.659 0.562 0.746 c 0.624 0.836 0.669 0.936 0.695 1.041 c 0.752 1.26 0.752 1.491 0.695 1.71 c 0.669 1.816 0.625 1.916 0.562 2.005 c 0.502 2.091 0.423 2.163 0.332 2.215 c 0.123 2.323 -0.126 2.323 -0.335 2.215 c -0.427 2.163 -0.505 2.091 -0.566 2.005 c -0.628 1.916 -0.673 1.816 -0.699 1.71 c -0.756 1.491 -0.756 1.26 -0.699 1.041 c -0.672 0.936 -0.627 0.836 -0.566 0.746 c -0.506 0.659 -0.427 0.586 -0.335 0.534 c -0.232 0.478 -0.117 0.451 0 0.454 c f Q q 1 0 0 1 431.8979 732.5762 cm 0 0 m 0.531 0 l 0.531 -0.505 l 0.55 -0.43 0.583 -0.359 0.629 -0.297 c 0.681 -0.229 0.74 -0.167 0.807 -0.114 c 0.877 -0.059 0.956 -0.014 1.039 0.019 c 1.123 0.053 1.213 0.07 1.304 0.069 c 1.52 0.069 l 1.52 -0.486 l 1.395 -0.467 l 1.269 -0.467 l 1.178 -0.468 1.087 -0.488 1.004 -0.526 c 0.917 -0.565 0.839 -0.625 0.778 -0.699 c 0.716 -0.783 0.669 -0.878 0.643 -0.98 c 0.604 -1.104 0.584 -1.233 0.586 -1.362 c 0.586 -2.603 l 0.01 -2.603 l 0.01 0 l 0 0 l f Q q 1 0 0 1 437.3666 729.9683 cm 0 0 m -0.577 0 l -0.577 0.364 l -0.649 0.23 -0.759 0.121 -0.893 0.047 c -1.022 -0.029 -1.169 -0.07 -1.32 -0.072 c -1.595 -0.095 -1.866 0.002 -2.064 0.194 c -2.234 0.413 -2.316 0.687 -2.295 0.964 c -2.295 2.608 l -1.719 2.608 l -1.719 1.014 l -1.735 0.843 -1.689 0.67 -1.588 0.531 c -1.492 0.433 -1.357 0.382 -1.219 0.39 c -1.116 0.387 -1.012 0.406 -0.917 0.446 c -0.84 0.479 -0.772 0.531 -0.72 0.595 c -0.667 0.661 -0.63 0.738 -0.611 0.82 c -0.588 0.911 -0.577 1.003 -0.577 1.097 c -0.577 2.611 l 0 2.611 l 0 0 l f Q q 1 0 0 1 437.9877 732.5762 cm 0 0 m 0.545 0 l 0.545 -0.353 l 0.617 -0.209 0.736 -0.094 0.882 -0.026 c 1.03 0.04 1.19 0.073 1.352 0.072 c 1.535 0.075 1.717 0.038 1.883 -0.037 c 2.031 -0.106 2.161 -0.208 2.263 -0.334 c 2.366 -0.465 2.442 -0.615 2.489 -0.775 c 2.54 -0.948 2.566 -1.127 2.566 -1.307 c 2.566 -1.479 2.542 -1.651 2.497 -1.817 c 2.455 -1.973 2.385 -2.121 2.29 -2.252 c 2.099 -2.522 1.789 -2.682 1.458 -2.68 c 1.369 -2.681 1.28 -2.674 1.193 -2.659 c 1.11 -2.644 1.028 -2.618 0.951 -2.584 c 0.875 -2.552 0.802 -2.509 0.736 -2.457 c 0.671 -2.406 0.615 -2.343 0.571 -2.273 c 0.571 -3.575 l -0.005 -3.575 l -0.005 0 l 0 0 l 2.008 -1.307 m 2.008 -1.191 1.993 -1.076 1.963 -0.964 c 1.936 -0.859 1.89 -0.759 1.828 -0.669 c 1.768 -0.584 1.69 -0.514 1.599 -0.462 c 1.503 -0.409 1.395 -0.382 1.286 -0.385 c 1.072 -0.372 0.867 -0.467 0.738 -0.638 c 0.607 -0.836 0.543 -1.072 0.555 -1.31 c 0.554 -1.433 0.57 -1.557 0.603 -1.676 c 0.631 -1.781 0.68 -1.879 0.747 -1.965 c 0.809 -2.044 0.886 -2.109 0.975 -2.157 c 1.071 -2.206 1.178 -2.23 1.286 -2.229 c 1.401 -2.232 1.517 -2.205 1.618 -2.148 c 1.708 -2.096 1.785 -2.025 1.843 -1.939 c 1.903 -1.85 1.945 -1.751 1.968 -1.646 c 1.995 -1.535 2.008 -1.421 2.008 -1.307 c f Q q 1 0 0 1 443.5127 729.9683 cm 0 0 m -0.545 0 l -0.545 0.353 l -0.616 0.211 -0.734 0.099 -0.879 0.034 c -1.027 -0.031 -1.187 -0.065 -1.349 -0.064 c -1.532 -0.067 -1.714 -0.03 -1.88 0.045 c -2.028 0.113 -2.158 0.214 -2.26 0.34 c -2.364 0.47 -2.441 0.62 -2.486 0.781 c -2.538 0.958 -2.564 1.143 -2.563 1.328 c -2.568 1.536 -2.536 1.742 -2.468 1.938 c -2.41 2.097 -2.319 2.242 -2.202 2.364 c -2.101 2.471 -1.977 2.555 -1.838 2.608 c -1.705 2.659 -1.563 2.685 -1.421 2.685 c -1.338 2.685 -1.256 2.678 -1.174 2.664 c -1.091 2.648 -1.01 2.624 -0.932 2.589 c -0.855 2.556 -0.783 2.514 -0.717 2.462 c -0.652 2.411 -0.597 2.349 -0.553 2.279 c -0.553 3.606 l 0.024 3.606 l 0.024 0 l 0 0 l -2.008 1.277 m -2.009 1.166 -1.994 1.056 -1.965 0.948 c -1.939 0.845 -1.896 0.748 -1.835 0.661 c -1.777 0.578 -1.699 0.508 -1.61 0.459 c -1.404 0.355 -1.162 0.355 -0.956 0.459 c -0.866 0.512 -0.789 0.585 -0.73 0.671 c -0.671 0.762 -0.626 0.862 -0.6 0.966 c -0.572 1.076 -0.558 1.188 -0.558 1.301 c -0.543 1.542 -0.612 1.781 -0.751 1.979 c -0.88 2.14 -1.078 2.229 -1.283 2.22 c -1.402 2.224 -1.52 2.196 -1.623 2.138 c -1.714 2.083 -1.793 2.009 -1.852 1.92 c -1.911 1.828 -1.954 1.725 -1.977 1.617 c -1.999 1.505 -2.01 1.392 -2.008 1.277 c f Q q 1 0 0 1 446.3252 730.5499 cm 0 0 m -0.004 -0.052 0.005 -0.104 0.026 -0.151 c 0.052 -0.185 0.094 -0.202 0.136 -0.197 c 0.197 -0.197 l 0.223 -0.2 0.25 -0.2 0.276 -0.197 c 0.276 -0.595 l 0.199 -0.619 l 0.101 -0.64 l 0 -0.656 l -0.085 -0.656 l -0.187 -0.66 -0.288 -0.635 -0.377 -0.584 c -0.461 -0.528 -0.516 -0.437 -0.528 -0.337 c -0.648 -0.451 -0.792 -0.534 -0.951 -0.579 c -1.106 -0.628 -1.269 -0.654 -1.432 -0.656 c -1.546 -0.657 -1.659 -0.641 -1.769 -0.608 c -1.872 -0.579 -1.967 -0.531 -2.053 -0.468 c -2.136 -0.405 -2.203 -0.324 -2.25 -0.231 c -2.3 -0.127 -2.326 -0.012 -2.324 0.104 c -2.33 0.24 -2.299 0.375 -2.236 0.497 c -2.181 0.594 -2.101 0.675 -2.005 0.733 c -1.905 0.791 -1.795 0.833 -1.681 0.855 c -1.562 0.88 -1.442 0.899 -1.32 0.914 c -1.222 0.933 -1.123 0.947 -1.022 0.956 c -0.938 0.963 -0.855 0.977 -0.773 0.999 c -0.708 1.014 -0.649 1.046 -0.6 1.092 c -0.556 1.144 -0.533 1.211 -0.536 1.28 c -0.534 1.344 -0.553 1.408 -0.59 1.46 c -0.624 1.507 -0.668 1.544 -0.72 1.569 c -0.775 1.596 -0.834 1.613 -0.895 1.62 c -0.955 1.624 -1.016 1.624 -1.076 1.62 c -1.215 1.625 -1.354 1.591 -1.474 1.519 c -1.581 1.45 -1.647 1.333 -1.652 1.206 c -2.231 1.206 l -2.227 1.354 -2.185 1.498 -2.108 1.625 c -2.041 1.733 -1.951 1.824 -1.843 1.891 c -1.729 1.96 -1.603 2.007 -1.472 2.032 c -1.329 2.072 -1.183 2.098 -1.036 2.109 c -0.908 2.109 -0.781 2.096 -0.656 2.069 c -0.538 2.044 -0.425 2 -0.321 1.939 c -0.225 1.88 -0.143 1.8 -0.083 1.705 c -0.02 1.599 0.012 1.478 0.008 1.354 c 0.008 0.013 l 0 0 l -0.576 0.728 m -0.674 0.667 -0.785 0.631 -0.9 0.624 c -1.028 0.612 -1.155 0.594 -1.283 0.571 c -1.343 0.561 -1.402 0.547 -1.46 0.528 c -1.515 0.511 -1.566 0.485 -1.612 0.451 c -1.657 0.419 -1.692 0.376 -1.716 0.327 c -1.742 0.267 -1.755 0.203 -1.753 0.138 c -1.755 0.079 -1.735 0.021 -1.697 -0.024 c -1.661 -0.067 -1.615 -0.103 -1.564 -0.127 c -1.509 -0.154 -1.451 -0.171 -1.392 -0.181 c -1.335 -0.19 -1.278 -0.196 -1.222 -0.197 c -1.152 -0.196 -1.083 -0.188 -1.015 -0.173 c -0.94 -0.156 -0.87 -0.127 -0.805 -0.088 c -0.74 -0.048 -0.684 0.004 -0.64 0.066 c -0.594 0.134 -0.571 0.215 -0.574 0.297 c -0.574 0.725 l h f Q q 1 0 0 1 446.6836 732.5762 cm 0 0 m 0.434 0 l 0.434 0.784 l 0.996 0.784 l 0.996 0 l 1.527 0 l 1.527 -0.43 l 0.996 -0.43 l 0.996 -1.822 l 0.993 -1.874 0.993 -1.927 0.996 -1.979 c 1 -2.018 1.011 -2.056 1.031 -2.09 c 1.05 -2.122 1.079 -2.146 1.113 -2.159 c 1.162 -2.177 1.213 -2.185 1.265 -2.183 c 1.387 -2.183 l 1.428 -2.181 1.469 -2.175 1.509 -2.165 c 1.509 -2.608 l 1.323 -2.629 l 1.261 -2.633 1.199 -2.633 1.137 -2.629 c 1.013 -2.633 0.89 -2.619 0.771 -2.587 c 0.688 -2.564 0.613 -2.52 0.553 -2.459 c 0.499 -2.4 0.462 -2.328 0.446 -2.25 c 0.427 -2.155 0.416 -2.059 0.415 -1.963 c 0.415 -0.428 l -0.019 -0.428 l -0.019 0 l 0 0 l f Q q 1 0 0 1 449.0742 731.1235 cm 0 0 m 0 -0.099 0.014 -0.198 0.042 -0.292 c 0.068 -0.382 0.112 -0.466 0.17 -0.54 c 0.229 -0.611 0.303 -0.669 0.388 -0.709 c 0.486 -0.754 0.593 -0.776 0.701 -0.773 c 0.845 -0.78 0.987 -0.742 1.107 -0.664 c 1.216 -0.582 1.296 -0.468 1.336 -0.337 c 1.88 -0.337 l 1.827 -0.603 1.674 -0.838 1.456 -0.996 c 1.349 -1.073 1.231 -1.131 1.105 -1.169 c 0.973 -1.208 0.836 -1.228 0.699 -1.227 c 0.512 -1.23 0.327 -1.196 0.154 -1.126 c 0.003 -1.066 -0.133 -0.973 -0.244 -0.855 c -0.356 -0.73 -0.44 -0.583 -0.491 -0.422 c -0.548 -0.243 -0.576 -0.056 -0.574 0.133 c -0.575 0.313 -0.546 0.493 -0.486 0.664 c -0.426 0.826 -0.336 0.974 -0.221 1.102 c 0.002 1.374 0.334 1.532 0.685 1.535 c 0.877 1.539 1.067 1.495 1.238 1.408 c 1.396 1.326 1.535 1.209 1.644 1.067 c 1.753 0.922 1.833 0.757 1.878 0.582 c 1.927 0.396 1.939 0.203 1.915 0.013 c -0.002 0.013 l 0 0 l 1.341 0.377 m 1.335 0.468 1.315 0.557 1.283 0.643 c 1.253 0.724 1.209 0.798 1.153 0.863 c 1.096 0.926 1.027 0.978 0.951 1.014 c 0.868 1.054 0.777 1.074 0.685 1.073 c 0.594 1.073 0.504 1.055 0.419 1.02 c 0.339 0.986 0.267 0.937 0.207 0.874 c 0.147 0.81 0.099 0.735 0.066 0.653 c 0.031 0.569 0.011 0.479 0.008 0.388 c 1.349 0.388 l h f Q q 1 0 0 1 451.8657 730.7994 cm 0 0 m 0.002 -0.142 0.073 -0.274 0.191 -0.353 c 0.312 -0.423 0.45 -0.458 0.59 -0.454 c 0.651 -0.458 0.711 -0.458 0.773 -0.454 c 0.839 -0.447 0.904 -0.43 0.967 -0.406 c 1.024 -0.385 1.075 -0.349 1.116 -0.303 c 1.155 -0.252 1.174 -0.189 1.168 -0.125 c 1.166 -0.057 1.138 0.008 1.089 0.056 c 1.033 0.107 0.967 0.146 0.895 0.17 c 0.809 0.201 0.72 0.226 0.629 0.245 c 0.329 0.33 l 0.224 0.352 0.121 0.38 0.019 0.415 c -0.076 0.446 -0.166 0.491 -0.247 0.55 c -0.327 0.608 -0.391 0.683 -0.436 0.771 c -0.486 0.873 -0.511 0.986 -0.507 1.1 c -0.512 1.226 -0.475 1.351 -0.404 1.456 c -0.333 1.551 -0.243 1.63 -0.138 1.687 c -0.028 1.747 0.092 1.788 0.215 1.809 c 0.337 1.832 0.462 1.843 0.587 1.843 c 0.716 1.844 0.845 1.83 0.972 1.801 c 1.09 1.774 1.202 1.727 1.304 1.663 c 1.404 1.598 1.488 1.513 1.551 1.413 c 1.621 1.3 1.663 1.173 1.676 1.041 c 1.076 1.041 l 1.059 1.155 0.989 1.253 0.887 1.307 c 0.78 1.355 0.665 1.38 0.547 1.378 c 0.5 1.381 0.452 1.381 0.403 1.378 c 0.35 1.373 0.298 1.36 0.247 1.341 c 0.2 1.325 0.157 1.297 0.122 1.262 c 0.087 1.224 0.069 1.174 0.071 1.124 c 0.069 1.058 0.096 0.995 0.146 0.951 c 0.202 0.903 0.267 0.866 0.337 0.842 c 0.424 0.811 0.512 0.786 0.603 0.768 c 0.917 0.701 l 1.021 0.678 1.124 0.65 1.224 0.616 c 1.319 0.584 1.409 0.539 1.49 0.481 c 1.662 0.359 1.762 0.16 1.755 -0.05 c 1.76 -0.189 1.723 -0.326 1.649 -0.443 c 1.582 -0.551 1.491 -0.642 1.384 -0.709 c 1.267 -0.778 1.14 -0.827 1.007 -0.855 c 0.873 -0.885 0.735 -0.9 0.598 -0.9 c 0.443 -0.902 0.29 -0.883 0.141 -0.845 c 0.01 -0.812 -0.114 -0.753 -0.223 -0.674 c -0.324 -0.601 -0.407 -0.504 -0.465 -0.393 c -0.527 -0.269 -0.559 -0.131 -0.558 0.008 c 0.019 0.008 l 0 0 l f Q 0.146 0.941 0.992 0.044 k q 1 0 0 1 401.2527 729.3892 cm 0 0 m 3.612 2.406 l 3.612 5.296 l 0 5.296 l h f Q 0 0.889 0.676 0 k q 1 0 0 1 404.865 729.3892 cm 0 0 m -3.612 2.406 l -3.612 5.296 l 0 5.296 l h f Q 0.694 0.076 0.209 0 k q 1 0 0 1 403.0589 735.3145 cm 0 0 m -2.2 0 -3.984 -1.784 -3.984 -3.984 c -3.984 -6.184 -2.2 -7.968 0 -7.968 c 2.2 -7.968 3.984 -6.184 3.984 -3.984 c 3.984 -1.784 2.2 0 0 0 c 0 -6.993 m -1.662 -6.993 -3.009 -5.646 -3.009 -3.984 c -3.009 -2.322 -1.662 -0.975 0 -0.975 c 1.662 -0.975 3.009 -2.322 3.009 -3.984 c 3.009 -5.646 1.662 -6.993 0 -6.993 c f Q 0 0.235 0.86 0 k q 1 0 0 1 405.2601 729.2803 cm 0 0 m -1.118 -1.208 -3.015 -1.281 -4.237 -0.159 c -5.159 0.688 -5.459 2.005 -4.999 3.156 c -5.833 3.687 l -6.736 1.681 -5.843 -0.679 -3.836 -1.582 c -2.218 -2.311 -0.312 -1.881 0.836 -0.528 c 0 0 l f Q 0 0 0 0.6 k q 1 0 0 1 397.4813 736.8087 cm 0 0 m -0.238 0 -0.432 -0.193 -0.432 -0.432 c -0.432 -10.524 l -0.432 -10.763 -0.238 -10.956 0 -10.956 c 57.901 -10.956 l 58.139 -10.956 58.333 -10.763 58.333 -10.524 c 58.333 -0.432 l 58.333 -0.193 58.139 0 57.901 0 c h 57.901 -11.155 m 0 -11.155 l -0.348 -11.155 -0.631 -10.872 -0.631 -10.524 c -0.631 -0.432 l -0.631 -0.084 -0.348 0.199 0 0.199 c 57.901 0.199 l 58.249 0.199 58.532 -0.084 58.532 -0.432 c 58.532 -10.524 l 58.532 -10.872 58.249 -11.155 57.901 -11.155 c f Q EMC Q endstream endobj 2597 0 obj <> endobj 2599 0 obj <>stream Adobe Illustrator CS6 (Windows) 2021-04-12T11:45:36+05:00 2021-06-02T10:28:09+05:00 2021-06-02T10:28:09+05:00 1 False False 20.868494 3.999928 Millimeters Cyan Magenta Yellow Black Default Swatch Group 0 C=0 M=24 Y=86 K=0 PROCESS 100.000000 CMYK 0.000000 23.504999 86.022697 0.000000 C=69 M=8 Y=21 K=0 PROCESS 100.000000 CMYK 69.369003 7.635600 20.892700 0.000000 C=0 M=89 Y=68 K=0 PROCESS 100.000000 CMYK 0.000000 88.946404 67.623398 0.000000 C=15 M=94 Y=99 K=4 PROCESS 100.000000 CMYK 14.578501 94.070297 99.160698 4.416000 C=0 M=0 Y=0 K=84 PROCESS 100.000000 CMYK 0.000000 0.000000 0.000000 84.000000 C=0 M=0 Y=0 K=35 PROCESS 100.000000 CMYK 0.000000 0.000000 0.000000 35.000000 C=0 M=0 Y=0 K=60 PROCESS 100.000000 CMYK 0.000000 0.000000 0.000000 60.000004 Document application/pdf proof:pdf xmp.did:804244B35A9BEB118A6FC3C256996E2F uuid:08e30110-bdb7-4606-97ca-63fb62cbcecc uuid:21079f76-f6d7-4329-b725-f2fb35af5114 uuid:722f8893-0b3c-4402-87fb-c713f1fa0e26 uuid:21079f76-f6d7-4329-b725-f2fb35af5114 uuid:21079f76-f6d7-4329-b725-f2fb35af5114 proof:pdf saved xmp.iid:804244B35A9BEB118A6FC3C256996E2F 2021-04-12T11:45:42+05:00 Adobe Illustrator CS6 (Windows) / endstream endobj 2598 0 obj <>/Border[0 0 0]/H/N/Rect[394.85 739.008 458.005 723.67]/Subtype/Link/Type/Annot>> endobj 2600 0 obj <> endobj 2593 0 obj [2601 0 R 2602 0 R 2603 0 R 2604 0 R 2605 0 R 2606 0 R 2607 0 R 2608 0 R 2609 0 R 2610 0 R 2611 0 R 2612 0 R 2613 0 R] endobj 2594 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.079 Tw 10 0 0 10 42.5197 690.033 Tm [(Rais R. Shakir)20(ov)21(, Y)40(uliia S. P)20(ankr)21.1(atov)10(a, Anastasiy)21.1(a M. Senina, Eugenia A)-31(. Bouly)10.1(gina, Olga S. K)41(ar)21(ase)11(v)10(a, )]TJ 0.023 Tw 0 -1.2 TD [(T)40(atiana V)61.9(. Grigor)-31(y)10(e)11(v)10(a, Dina R. Y)50(ar)10(ullina, Oleg Y)45(. K)41(arpukhin)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0.089 Tw 13 0 0 13 42.5197 659.5984 Tm [(Mucosal micr)24(obiota of the diver)-19.9(ticula in inflammator)-30.9(y complications of diver)-20(ticular )]TJ 0.023 Tw T* (disease \(a pilot study\))Tj 0 Tw /Span<>> BDC 8.531 0 Td (. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . \ . . . . . . . . . . . . . . . . . .)Tj EMC -0.063 Tc 0.063 Tw 24.716 0 Td [(10)-63(8)]TJ 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0 Tc 0.04 Tw 10 0 0 10 42.5197 626.3292 Tm [(Sv)12(etlana )0.5(V)62(. Sht)-19.9(yrk)11(ov)10(a, Olga )0.5(A)-31(. )0.5(Sobole)11(v)10(a, Kirill )0.6(R. Sabir)20(ov)21(, )0.5(V)30(y)21(ach)11(eslav )0.5(A)-31(. Novik)11(ov)21.1(, K)41(ar)31(en I. )0.5(Ntanish)31.1(y)21(an, )]TJ 0.023 Tw T* [(Elena N. P)20(ar)20(ovichnik)11(ov)10(a )]TJ 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0.009 Tc 0.35 Tw 13 0 0 13 42.5197 595.8947 Tm [(Diagnostics and tr)23.8(eatment of complicated perianal abscess in patients with)9( )]TJ 0 Tc 0.023 Tw T* (hematologic malignancies)Tj 0 Tw /Span<>> BDC 10.375 0 Td [(. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . \ . . . . . . . )0.7(. . . . . . . )]TJ EMC -0.225 Tc 0.225 Tw 23.146 0 Td [(11)-113(7)]TJ 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0 Tc 0.023 Tw 10 0 0 10 42.5197 562.6254 Tm [(Erik N. Sh)11(ubr)20(ov)21(, Ale)21(x)11(ander G. Bar)-31(y)10(sh)11(e)11(v)21(, K)41(onstantin V)62.1(. T)20(riandaf)-21(ilov)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 13 0 0 13 42.5197 544.1908 Tm [(A new method for wound defect closur)24.1(e af)-20(ter pilonidal sinus excision)]TJ 0 Tw /Span<>> BDC [( )226.2( . . . . . . . . . . . . . .)]TJ EMC -0.15 Tc 0.15 Tw 33.371 0 Td [(12)-113(9)]TJ /T1_2 1 Tf 0.01 Tc 0.018 Tw -33.366 -2.072 Td [(CA)21(SE)5( REPORT)]TJ 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0 Tc 0.023 Tw 10 0 0 10 42.5197 496.7484 Tm [(K)20(senia A)-30.9(. Ch)11(usov)10(a, Ale)21(x)10(ey V)62(. Bogdanov)21(, Ily)21(a L. Stark)11(ov)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 13 0 0 13 42.5197 478.3138 Tm [(T)72(ubular duplication of the sigmoid colon: clinical case)]TJ 0 Tw /Span<>> BDC 20.977 0 Td (. . . . . . . . . . . . . . . . . . . . . . . . . . .)Tj EMC -0.137 Tc 0.137 Tw 12.344 0 Td [(13)-137(6)]TJ /T1_2 1 Tf 0.01 Tc -0.01 Tw -33.316 -2.072 Td (REVIEW)Tj 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0 Tc 0.023 Tw 10 0 0 10 42.5197 430.8713 Tm [(T)40(at)-20(y)21(ana A)-30.9(. Vlask)11(o, Ale)21.1(x)10(ey A)-31(. Lik)11(utov)21.1(, Viktor V)62(. V)30(eselov)21(, Ale)21(x)10(ey A)-31(. P)10(onomar)31(enk)11(o, Ale)21(x)10(ey S. T)40(sukanov)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 13 0 0 13 42.5197 412.4367 Tm [(Juvenile polyposis syndr)24(ome \(r)24(eview\))]TJ 0 Tw /Span<>> BDC 14.523 0 Td (. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . \ . . . . .)Tj EMC -0.125 Tc 0.125 Tw 18.835 0 Td [(14)-75(2)]TJ 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0 Tc 0.023 Tw 10 0 0 10 42.5197 394.7674 Tm [(Ser)31(gey V)62(. K)40.9(ost)-19.9(y)10(uk)11(e)11(vich, Igor G. Bak)11(ulin)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 13 0 0 13 42.5197 376.3328 Tm [(Phy)10(sical exer)24(cises as an ef)-19.9(fective adjuvant ther)21(apy of IBD in r)24(emission \(r)24(eview\))]TJ 0 Tw /Span<>> BDC [( )204.5( . . . . . .)]TJ EMC -0.125 Tc 0.125 Tw 33.359 0 Td [(15)-75(2)]TJ 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0 Tc 0.023 Tw 10 0 0 10 42.5197 358.6636 Tm [(Anatoliy N. K)31(ur)20(z)15(anov)21(, Vladimir M. Durleshter)52.1(, Mikhail I. Byk)11(ov)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 13 0 0 13 42.5197 340.229 Tm [(Color)24(ectal cancer associated with par)21(athyr)24(oid hormone)-52(-r)24(elated pr)24(otein \(r)24(eview\))]TJ 0 Tw /Span<>> BDC 31.119 0 Td (. . . . .)Tj EMC -0.1 Tc 0.1 Tw 2.202 0 Td [(16)-63(2)]TJ 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0 Tc 0.023 Tw 10 0 0 10 42.5197 322.5597 Tm [(Air)21(at F)93.9(. Minga)20(z)10(ov)21(, Oleg I. Sushk)11(ov)21(, Bulat R. K)41(alanov)21(, T)40(atiana A)-31(. Bar)21(anov)10(a, Ser)31(gey I. Achkasov)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0.123 Tw 13 0 0 13 42.5197 304.1251 Tm [(Pr)24(edictor)11.1(s of )0.5(adver)11(se )0.5(outcomes )0.5(of )0.5(ster)24(oids )0.5(in )0.5(patients with sever)24(e ulcer)21.1(ative colitis )]TJ 0.023 Tw T* [(\(sy)10(stematic r)24(eview and meta-analy)10.1(ses\))]TJ 0 Tw /Span<>> BDC 14.984 0 Td (. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . \ . . . .)Tj EMC -0.112 Tc 0.112 Tw 18.361 0 Td [(17)-62(2)]TJ 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0 Tc 0.023 Tw 10 0 0 10 42.5197 270.8559 Tm [(Roman K. Sinits)10.1(yn, Michael V)62(. Alek)11.1(see)11(v)21(, Stanislav V)62(. Ch)11(erny)10(sh)11(ov)21(, Eugeny G. R)20(ybak)11(ov)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0.148 Tw 13 0 0 13 42.5197 252.4213 Tm [(Is it safe to leave r)24(ectal wound opened af)-19.9(ter tr)21(ansanal micr)24(osur)24(ger)-31(y? \(sy)10.1(stematic )]TJ 0.023 Tw T* [(r)24(eview and meta-analy)10.1(sis\))]TJ 0 Tw /Span<>> BDC 10.375 0 Td [(. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . \ . . . . . . . )0.7(. . . . . . . )]TJ EMC -0.137 Tc 0.137 Tw 23.071 0 Td [(1)-12(81)]TJ ET 1 0.68 0 0.12 K q 1 0 0 1 42.5197 712.412 cm 0 0 m 453.543 0 l S Q BT /T1_0 1 Tf 0.06 Tc -0.06 Tw 17.5 0 0 17.5 224.0281 724.2505 Tm [(C)21(ONTENTS)]TJ /T1_3 1 Tf 0 Tc 0 Tw 25 0 0 25 519.3393 56.0378 Tm (9)Tj /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 23, \023\0221)69(, 202)69(4)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 23, \023\0221)69(, 202)69(4)]TJ ET endstream endobj 2601 0 obj <>/Border[0 0 0]/H/N/Rect[42.5197 671.636 469.067 656.348]/Subtype/Link/Type/Annot>> endobj 2602 0 obj <>/Border[0 0 0]/H/N/Rect[42.5197 656.036 496.063 640.748]/Subtype/Link/Type/Annot>> endobj 2603 0 obj <>/Border[0 0 0]/H/N/Rect[42.5197 607.933 472.454 592.645]/Subtype/Link/Type/Annot>> endobj 2604 0 obj <>/Border[0 0 0]/H/N/Rect[42.5197 592.333 496.063 577.045]/Subtype/Link/Type/Annot>> endobj 2605 0 obj <>/Border[0 0 0]/H/N/Rect[42.5197 556.229 496.063 540.941]/Subtype/Link/Type/Annot>> endobj 2606 0 obj <>/Border[0 0 0]/H/N/Rect[42.5197 490.352 496.063 475.064]/Subtype/Link/Type/Annot>> endobj 2607 0 obj <>/Border[0 0 0]/H/N/Rect[42.5197 424.475 496.063 409.187]/Subtype/Link/Type/Annot>> endobj 2608 0 obj <>/Border[0 0 0]/H/N/Rect[42.5197 388.371 496.063 373.083]/Subtype/Link/Type/Annot>> endobj 2609 0 obj <>/Border[0 0 0]/H/N/Rect[42.5197 352.267 496.063 336.979]/Subtype/Link/Type/Annot>> endobj 2610 0 obj <>/Border[0 0 0]/H/N/Rect[42.5197 316.163 469.504 300.875]/Subtype/Link/Type/Annot>> endobj 2611 0 obj <>/Border[0 0 0]/H/N/Rect[42.5197 300.563 496.063 285.275]/Subtype/Link/Type/Annot>> endobj 2612 0 obj <>/Border[0 0 0]/H/N/Rect[42.5197 264.459 469.837 249.171]/Subtype/Link/Type/Annot>> endobj 2613 0 obj <>/Border[0 0 0]/H/N/Rect[42.5197 248.859 496.063 233.571]/Subtype/Link/Type/Annot>> endobj 2626 0 obj <> endobj 2625 0 obj <> endobj 2624 0 obj <> endobj 2623 0 obj <> endobj 2622 0 obj <> endobj 2621 0 obj <> endobj 2620 0 obj <> endobj 2619 0 obj <> endobj 2618 0 obj <> endobj 2617 0 obj <> endobj 2616 0 obj <> endobj 2615 0 obj <> endobj 2614 0 obj <> endobj 2591 0 obj [2627 0 R 2628 0 R 2629 0 R 2630 0 R 2631 0 R 2632 0 R 2633 0 R 2634 0 R 2635 0 R 2636 0 R 2637 0 R 2638 0 R 2639 0 R 2640 0 R 2641 0 R] endobj 2592 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 0.01 Tc 0.018 Tw 13 0 0 13 70.931 687.8461 Tm [(LEADING)5( ARTICLE)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0 Tc 0.317 Tw 10 0 0 10 70.8661 667.3422 Tm [(Ser)31(gey I. Sy)10(ch)11(e)11(v)21(, Ev)10(geny G. R)20(ybak)11(ov)21(, Mikhail V)62(. Alek)11.1(see)11(v)21(, Stanislav V)62(. Ch)11(erny)10.1(sh)11(ov)21(, Alek)11(sey A)-31(. )]TJ 0 Tw 0 -1.2 TD [(P)10(onomar)31(enk)11.1(o)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf -0.027 Tw 13 0 0 13 70.8661 636.9076 Tm [(Ef)-20(fectiveness of the total neoadjuvant ther)21(apy in r)24(ectal cancer tr)24(eatment. R)20(esults of the )]TJ 0.023 Tw T* [(r)21(andomiz)10.1(ed trial)]TJ 0 Tw /Span<>> BDC [( )158.3( . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .\ . . . . . . . )0.8(. . . . . . . . . . . . . . . .)]TJ EMC -0.063 Tc 0.063 Tw 33.815 0 Td (10)Tj /T1_0 1 Tf 0.01 Tc 0.018 Tw -33.81 -2.072 Td [(ORIGINAL)5( ARTICLES)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0 Tc 0.121 Tw 10 0 0 10 70.8661 573.8652 Tm [(Elmir)21.1(a U. Abdul)11(zhalie)11(v)10(a, Ale)21(x)10(ei A)-31(. Lik)11(utov)21(, Victor V)62(. V)30.1(eselov)21(, Dmitr)-31(y A)-31(. Mt)-9.9(vr)21(alashvili, Oleg M. Y)40(ugai, )]TJ 0.023 Tw T* [(Ev)10(geny A)-31(. Kh)11(om)21(y)21(ak)11(ov)21(, Stanislav V)62(. Ch)11(erny)10(sh)11(ov)21(, Oleg I. Sushk)11(ov)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.03 Tw 13 0 0 13 70.8661 543.4305 Tm [(Endoscopic )0.7(mucosal )0.6(r)23.9(esection )0.7(with )0.5(a )0.6(cir)24(cumfer)24(ential )0.6(incision )0.6(in )0.5(the )0.5(r)24(emoval )0.6(of )0.5(colon )]TJ 0.023 Tw 0 -1.2 TD [(neoplasms. R)20(esults of a r)21(andomiz)10.1(ed trial)]TJ 0 Tw /Span<>> BDC [( )160.6( . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .\ . . . )]TJ EMC -0.15 Tc 0.15 Tw 33.902 0 Td (21)Tj 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0 Tc 0.317 Tw 10 0 0 10 70.8661 510.1614 Tm [(Denis V)62(. Aleshin, Ser)31.1(gey I. Achkasov)21(, Dmitriy G. Shakhmatov)21.1(, Ok)11(sana Y)40(u. F)15(omenk)11(o, Alek)11(sey A)-31(. )]TJ 0.023 Tw 0 -1.2 TD [(P)10(onomar)31(enk)11.1(o, Maria A)-31(. Ignatenk)11.1(o, Ev)10(geniy S. Sur)20(ov)12(egin, Oleg I. Sushk)11(ov)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 13 0 0 13 70.8661 479.7268 Tm [(Risk factor)11.1(s of sigmoid volvulus in patients with idiopathic megacolon)]TJ 0 Tw /Span<>> BDC [( )202.9( . . . . . . . . . . . . . . .)]TJ EMC -0.05 Tc 0.05 Tw 33.802 0 Td (32)Tj 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0 Tc 0.023 Tw 10 0 0 10 70.8661 462.0575 Tm [(Z)21(arina Z. K)41(amae)11(v)10(a, Alek)11(sandr Y)40(u. Titov)21(, Roman Y)40(u. Khr)-31(y)10(ukin, Iv)10(an S. Anosov)21.1(, Y)40(uri A)-31(. Sh)11(ely)10(gin)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.14 Tw 13 0 0 13 70.8661 443.6229 Tm [(\032ontr)24(olled cir)24(cular dilatation and later)21.1(al subcutaneous sphincter)24(otomy for chr)23.9(onic )]TJ 0.023 Tw T* [(anal fissur)24(es associated with hemorrhoids III-IV)]TJ 0 Tw /Span<>> BDC 18.211 0 Td (. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .)Tj EMC -0.05 Tc 0.05 Tw 15.591 0 Td (42)Tj 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0 Tc 0.04 Tw 10 0 0 10 70.8661 410.3537 Tm [(Oleg I. Kit, Y)40(uri A)-30.9(. Ge)11(v)10(orky)21(an, Natalia V)62(. Soldatkina, Ev)10(geny N. K)41(olesnik)11.1(ov)21(, Marina A)-31(. Gusar)31(e)11(v)10(a, Olga )]TJ 0.023 Tw T* [(K. Bondar)31(enk)11.1(o, Ale)21(x)11(ander E. Anisimov)21(, L)19.9(y)10(ubov Y)45(. Vladimir)20(ov)10(a)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 13 0 0 13 70.8661 379.9191 Tm [(R)20(esults of r)24(ectal r)24(esection in metastatic cancer)]TJ 0 Tw /Span<>> BDC 17.75 0 Td (. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .)Tj EMC -0.05 Tc 0.05 Tw 16.052 0 Td (52)Tj 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0 Tc 0.029 Tw 10 0 0 10 70.8661 362.2498 Tm [(Iv)10(an V)62.1(. K)41(ostar)31(e)11(v)21(, Ale)21(x)11(ander V)62(. Z)21(akhar)-30.9(y)21(an, Dmitr)-30.9(y O. Kisele)11(v)21(, Leonid A)-31(. Blagodarny)31(, Andr)31.1(ey A)-31(. Mudr)20(ov)21(, )]TJ 0.023 Tw T* [(Ale)21(x)11(ander Y)40(u. Titov)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.215 Tw 13 0 0 13 70.8661 331.8153 Tm [(Five)-52(-year experience of laser coagulation in the tr)24(eatment of tr)21(ans- and supr)21(a)]TJ /Span<>> BDC (-)Tj EMC 0.023 Tw T* [(sphincteric\016)-23.2(anal fistulas)]TJ 0 Tw /Span<>> BDC 8.992 0 Td [(. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . \ . . . . . . . . )0.7(. . . . . . . . . .)]TJ EMC 24.76 0 Td (59)Tj 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0.023 Tw 10 0 0 10 70.8661 298.5461 Tm [(Daniil R. Markar)-30.9(y)21(an, Ale\207ander M. Lukianov)21(, Dmitr)-31(y O. Kisele)11.1(v)21(, Mikhail A)-31(. Agapov)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 13 0 0 13 70.8661 280.1115 Tm [(Pr)24(ognoses of injur)-30.9(y scale in sur)24(gical tr)24(eatment of post)-19.9(tr)21(aumatic anal incontinence)]TJ 0 Tw /Span<>> BDC [( )98.2( . . . . . )]TJ EMC -0.137 Tc 0.137 Tw 33.889 0 Td (71)Tj 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0 Tc -0.029 Tw 10 0 0 10 70.8661 262.4422 Tm [(Alek)11(sey A)-31(. Ne)11(v)10(olskikh, Ale)21.1(x)11(ander R. Br)20(odskiy)31(, Violet)-19.9(ta A)-30.9(. A)20(v)10(deenk)11(o, T)40.1(ar)21(as P)94(. P)10(och)11(ue)11(v)21(, Y)40.1(ulia Y)40(u. Mihale)11.1(v)10(a, )]TJ 0.073 Tw T* [(T)40(atiana P)94(. Ber)31.1(e)21(z)10(ov)10(skay)21(a, Ruslan F)94(. Zibir)20.1(ov)21(, Sof)-21(ia A)-31(. My)21(alina, Iv)10(an A)-31(. Or)31(eh)11(ov)21(, Leonid O. P)10(etr)20.1(ov)21(, Ser)31(gey )]TJ 0.023 Tw 0 -1.2 TD [(A)-31(. Iv)10(anov)21(, Andr)31(ey D. K)41(aprin)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.158 Tw 13 0 0 13 70.8661 220.0076 Tm [(T)72(r)21(ansanal )0.6(endoscopic )0.6(micr)24(osur)24(ger)-30.9(y )0.5(af)-20(ter )0.5(r)21(adiation )0.6(or )0.5(chemor)21.1(adiation ther)21(apy )0.5(for )]TJ 0.023 Tw T* [(r)24(ectal cancer \237 peculiarities and r)24(esults)]TJ 0 Tw /Span<>> BDC [( )148.6( . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .\ . . . .)]TJ EMC -0.038 Tc 0.038 Tw 33.79 0 Td (82)Tj 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0 Tc 0.259 Tw 10 0 0 10 70.8661 186.7384 Tm [(Alek)11(sandr )0.6(G. )0.6(Khitar)-30.9(y)21(an, )0.5(Suleiman )0.6(A)-30.9(. )0.5(Adiz)10(ov)21(, )0.6(Alber)-19.9(t )0.5(Z. )0.6(Alibek)11(ov)21(, )0.6(V)31(asiliy )0.6(N. )0.6(Kisly)21(ak)11(ov)21(, )0.6(Alek)11(sey )0.6(A)-31(. )]TJ 0.023 Tw T* [(Or)31(ekh)11(ov)21(, V)30(er)21.1(a A)-31(. Khitar)-30.9(y)21(an, K)20(seniy)21(a S. Oplimakh, Anastasia A)-30.9(. Golovina)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 13 0 0 13 70.8661 156.3038 Tm [(ICG-angiogr)21.1(aphy for r)24(ectal advancement flap in patients with anal fistulas)]TJ 0 Tw /Span<>> BDC 28.814 0 Td (. . . . . . . . . . .)Tj EMC -0.112 Tc 0.112 Tw 5.05 0 Td (91)Tj 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0 Tc 0.003 Tw 10 0 0 10 70.8661 138.6346 Tm [(Aly)21(ona L. Ch)11(erny)10(sh)11(ov)10(a, Vitaliy A)-31(. Mark)11(ovich, Ale)21(x)11(ander A)-30.9(. Ch)11(erny)21(ak)11(ov)21(, Ser)31(gey E. Kr)21(asilnik)11.1(ov)21(, Anastasia )]TJ 0.023 Tw T* [(O. Sh)11(umeikina, Y)40(ulia M.\022)-23.2(T)20(r)10(ush)11(uk, Olga S. Dil, Arina E. Ch)11(erny)10(sh)11.1(ov)10(a, Y)50(ana I. Arkhipov)10.1(a)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 13 0 0 13 70.8661 108.2 Tm [(Color)24(ectal cancer and pr)24(egnancy)]TJ 0 Tw /Span<>> BDC [( )14.1( . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .\ . . . . . . )0.7(.)]TJ EMC -0.063 Tc 0.063 Tw 33.247 0 Td [(10)-63(0)]TJ ET 1 0.68 0 0.12 K q 1 0 0 1 70.8661 712.412 cm 0 0 m 453.543 0 l S Q BT /T1_1 1 Tf 0.06 Tc -0.06 Tw 17.5 0 0 17.5 252.3746 724.2505 Tm [(C)21(ONTENTS)]TJ 0 Tc 0 Tw 7.5 0 0 7.5 70.8661 42.7216 Tm [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 23, \023\0221)69(, 202)69(4)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 23, \023\0221)69(, 202)69(4)]TJ /T1_3 1 Tf 25 0 0 25 34.6275 56.0378 Tm (8)Tj ET endstream endobj 2627 0 obj <>/Border[0 0 0]/H/N/Rect[70.8661 648.945 495.904 633.658]/Subtype/Link/Type/Annot>> endobj 2628 0 obj <>/Border[0 0 0]/H/N/Rect[70.8661 633.345 524.409 618.058]/Subtype/Link/Type/Annot>> endobj 2629 0 obj <>/Border[0 0 0]/H/N/Rect[70.8661 555.468 496.64 540.181]/Subtype/Link/Type/Annot>> endobj 2630 0 obj <>/Border[0 0 0]/H/N/Rect[70.8661 539.868 524.409 524.581]/Subtype/Link/Type/Annot>> endobj 2631 0 obj <>/Border[0 0 0]/H/N/Rect[70.8661 491.765 524.409 476.477]/Subtype/Link/Type/Annot>> endobj 2632 0 obj <>/Border[0 0 0]/H/N/Rect[70.8661 455.661 498.074 440.373]/Subtype/Link/Type/Annot>> endobj 2633 0 obj <>/Border[0 0 0]/H/N/Rect[70.8661 440.061 524.409 424.773]/Subtype/Link/Type/Annot>> endobj 2634 0 obj <>/Border[0 0 0]/H/N/Rect[70.8661 391.957 524.409 376.669]/Subtype/Link/Type/Annot>> endobj 2635 0 obj <>/Border[0 0 0]/H/N/Rect[70.8661 343.853 493.228 328.565]/Subtype/Link/Type/Annot>> endobj 2636 0 obj <>/Border[0 0 0]/H/N/Rect[70.8661 328.253 524.409 312.965]/Subtype/Link/Type/Annot>> endobj 2637 0 obj <>/Border[0 0 0]/H/N/Rect[70.8661 292.149 524.409 276.861]/Subtype/Link/Type/Annot>> endobj 2638 0 obj <>/Border[0 0 0]/H/N/Rect[70.8661 232.046 498.305 216.758]/Subtype/Link/Type/Annot>> endobj 2639 0 obj <>/Border[0 0 0]/H/N/Rect[70.8661 216.446 524.409 201.158]/Subtype/Link/Type/Annot>> endobj 2640 0 obj <>/Border[0 0 0]/H/N/Rect[70.8661 168.342 524.409 153.054]/Subtype/Link/Type/Annot>> endobj 2641 0 obj <>/Border[0 0 0]/H/N/Rect[70.8661 120.238 524.409 104.95]/Subtype/Link/Type/Annot>> endobj 2656 0 obj <> endobj 2655 0 obj <> endobj 2654 0 obj <> endobj 2653 0 obj <> endobj 2652 0 obj <> endobj 2651 0 obj <> endobj 2650 0 obj <> endobj 2649 0 obj <> endobj 2648 0 obj <> endobj 2647 0 obj <> endobj 2646 0 obj <> endobj 2645 0 obj <> endobj 2644 0 obj <> endobj 2643 0 obj <> endobj 2642 0 obj <> endobj 2589 0 obj [2657 0 R 2658 0 R 2659 0 R 2660 0 R 2661 0 R 2662 0 R 2663 0 R 2664 0 R 2665 0 R 2666 0 R 2667 0 R 2668 0 R 2669 0 R 2670 0 R 2671 0 R 2672 0 R 2673 0 R] endobj 2590 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 0 0 0 1 k /GS1 gs /T1_0 1 Tf -0.056 Tw 10 0 0 10 42.5197 690.033 Tm [(\003\016\002\001\020\025\r\013 \b)-31(.\035., \005\013\002\n)10(\025\r\220\017 \004.\b)-31(., \003\016\002\001\205\n)10.1(\025\r \b)-31(.\b)-30.9(., \037)20(\002\013\006\220\007\216\001\220\n)10.1(\025\r \021.\235., \206\215\024\016\203\n\220\001\013 \b)-31(.\b)-31(., \032)30(\002\215\224\215\n\022)55.9(\200.\005., )]TJ 0.023 Tw 0 -1.2 TD [(\255\220\007\216 \036.\021., \003\016\002\001\020\025\r\013 \b)-30.9(.\t., \b\002)20(\207\220\221\025\r\013 \027.\030.)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 13 0 0 13 42.5197 659.5984 Tm [(\027)42(\013\003\013\205\b\255\t)13.1(\220\003\214\n\211\201 \205\220\255 \002 \203\b\205\b\215\b\n\n\013\006\t\ \214)]TJ 0 Tw /Span<>> BDC [( )184.1( . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .\ . . .)]TJ EMC -0.063 Tc 0.063 Tw 33.247 0 Td [(10)-63(0)]TJ 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0 Tc 0.243 Tw 10 0 0 10 42.5197 641.9292 Tm [(\206\013\n\220\002\025\r )0.5(\033)124(.\033)124(., )0.5(\034\013\001\n\002\013\026)11.1(\025\r\013 )0.5(\200.\021., \021\016\001\220\001\013 )0.6(\b)-31(.\005., )0.5(\214\215\007\020\202\220\001\013 )0.6(\t.\b)-31(., )0.5(\037)41(\013\002\013\006\016\r\013 )0.5(\036.\021., )0.5(\031)68(\002\220\202)10(\025\002\216\016\r\013 )0.5(\032.\004., )]TJ 0.023 Tw T* [(\027\002\215\007\007\220\001\013 \255.\033)124(., \037)41(\013\002\221\215)21(\207\220\001 \036.\200.)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0.001 Tc 0.35 Tw 13 0 0 13 42.5197 611.4946 Tm [(\f\205\002\006\t)9.9(\b\n\013\207\n\220\235 )0.5(\215\002\255\205\013\203\002\013)9.9(\t)12.9(\220 \007\002\200\b\205)9.9(\t\002\255\005)9.9(\003\013\200 )0.5(\004\205\002 )0.5(\200\013\006\004\220\003\002\t)9.9(\b\003\214\n\211\216 \013\006\003\013\206\n\b\n\002\235\216)1( )]TJ 0 Tc 0.023 Tw T* [(\007\002\200\b\205)10(\t\002\255\005)10.1(\003\235\205\n\013\201 \203\013\003\b)10.1(\n\002 \(\004\002\003\013)10(\t\n\013\b \002\006\006\003\b\007\013\200\220\n\002\b\))]TJ 0 Tw /Span<>> BDC [( )153.2( . . . . . . . . . . . . . . . . . . . . . . . . . .)]TJ EMC -0.063 Tc 0.063 Tw 33.247 0 Td [(10)-63(8)]TJ 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0 Tc 0.023 Tw 10 0 0 10 42.5197 578.2253 Tm [(\206\026\020\002\n)10.1(\025\r\013 \021.\004., \021\025\f\025\007\016\r\013 \036.\b)-31(., \021\013\f\220\002\025\r \037.\033)124(., \213\025\r\220\n)10(\025\r \004.\b)-31(., \255\013\001\220\205\001 \037.\030., \034\013\002\025\r\220\017\001\220\ \n)10.1(\025\r\013 \t.\213.)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0.29 Tw 13 0 0 13 42.5197 559.7908 Tm [(\226\002\220\213\n\013\006\t\002\255\220 \002 \003\b\207\b\n\002\b \006\003\ \013\206\n\211\216 \202\013\205\215 \013\006\t\205\013\213)21.1(\013 \004\220\205\220\004\205\013\255\t\002\t)13(\220 \005 \004\220\001\002\b\n\t)10(\013\200 )]TJ 0.023 Tw T* [(\006\016)-23.3(\013\004\005\216\013\003\b\200\211\215\002 \220\203\013\003\b\200\220\n\ \002\235\215\002 \006\002\006\t)10(\b\215\211 \255\205\013\200\002)]TJ 0 Tw /Span<>> BDC 19.133 0 Td (. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . )Tj EMC -0.225 Tc 0.225 Tw 14.388 0 Td [(11)-113(7)]TJ 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0 Tc 0.023 Tw 10 0 0 10 42.5197 526.5215 Tm [(\206\215\f\002\025\r \235.\213., \214\013\002\020\016\r \b)-30.9(.\031)71.9(., \032)30(\002\220\013\001\201\013\225\220\007\025\r \037.\004.)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0.303 Tw 13 0 0 13 42.5197 508.0869 Tm [(\022\013\200\211\201 )0.5(\006\004\013\006)11(\013\203 )0.5(\004\003\220\006\t\002\207\b\006\255)20(\013\213)21.1(\013 \220\255\205\211\t\002\235 )0.5(\205\220\n\b\200\013\213)21.1(\013 \007\b\202\b\255\t)13(\220 \004\013\006\003\b )0.5(\002\006\006\b\207\b\n\002\235 )]TJ 0.023 Tw T* (\004\002\003\013\n\002\007\220\003\214\n\013\201 \255\002\006\t\211)Tj 0 Tw /Span<>> BDC [( )224.5( . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .\ . . . . . . .)0.7( . . . . . . . . . .)]TJ EMC -0.15 Tc 0.15 Tw 33.371 0 Td [(12)-113(9)]TJ /T1_2 1 Tf 0.01 Tc 0.018 Tw -33.366 -2.072 Td [(\212\b\006\t\006\223\207\017\212\006\207)5( \t\037\210)21.1(\b\204\216\207\t\006\224)]TJ 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0 Tc 0.023 Tw 10 0 0 10 42.5197 445.0445 Tm [(\003\215\006\025\r\013 \037.\b)-30.9(., \214\025\202)21(\201\013\001\025\r \b)-31(.\004., \021\026)11(\013\002\n)10(\025\r \030.\035.)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 13 0 0 13 42.5197 426.6099 Tm [(\024)62(\005\203\005)10(\003\235\205\n\013\b \005\007\200\013\b\n\002\b \006\002\213)10(\215\013\200\002\007\n\013\201 \255\002\222\255\002: \013\004\002\006\220\ \n\002\b \255)-11(\003\002\n\002\207\b\006\255)20(\013\213)21(\013 \006\003\005)9.9(\207\220\235)]TJ 0 Tw /Span<>> BDC 30.197 0 Td (. . . . . . .)Tj EMC -0.137 Tc 0.137 Tw 3.124 0 Td [(13)-137(6)]TJ /T1_2 1 Tf 0.01 Tc 0.018 Tw -33.316 -2.072 Td [(\004\210)42(\215\004\n)5( \b\006\r\207\n)43(\037)31(\r)-21(\013\n\233)5( \006)4.9( \213\207)-21(\r)41(\037\037\t\037)-20(\b\006\215)]TJ 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0 Tc 0.023 Tw 10 0 0 10 42.5197 379.1675 Tm [(\004\007\013\006\n)10(\025 \032.\b)-31(., \035\220\n\215)-20(\026)11(\025\r \b)-31(.\b)-31(., \004\016\006\016\007\025\r \004.\004., \034\025\001\025\024\013\002\016\ \001\n)10.1(\025 \b)-31(.\b)-31(., \226\215\n\013\001\025\r \b)-31(.\021.)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 13 0 0 13 42.5197 360.7329 Tm [(\032\002\n\007\205\013\215 \230\200\b\n\002\003\214\n\013\213)21(\013 \004\013\003\002\004\013\220 \(\013\203\013\205 \003\002\t)10.1(\b\205\220\t)-20(\005\205\211\))]TJ 0 Tw /Span<>> BDC 21.899 0 Td (. . . . . . . . . . . . . . . . . . . . . . . . .)Tj EMC -0.125 Tc 0.125 Tw 11.46 0 Td [(14)-75(2)]TJ 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0 Tc 0.023 Tw 10 0 0 10 42.5197 343.0636 Tm [(\037)31(\025\006)-10(\026\212\n\016\r\220\017 \021.\004., \214\013\n\215\007\220\001 \030.\031\ )72(.)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0.048 Tw 13 0 0 13 42.5197 324.629 Tm [(\231\002\002\207\b\006\255\002\b \005\004\205\220\206\n\b\n\002\235 \255\ \220\255 \210\202\202\b\255\t\002\200\n\220\235 \220\007\236\230\200\220\ \n\t\n\220\235 \t)10(\b\205\220\004\002\235 \004\205\002 \205\b\215\002\006\006\002\002 )]TJ 0.023 Tw T* [(\200\013\006\004\220\003\002\t)10.1(\b\003\214\n\211\216 \220\203\013\003\b\200\220\n\002\201 \255\002\222\b\ \207\n\002\255\220 \(\013\203\013\205 \003\002\t)10(\b\205\220\t)-19.9(\005\205\211\))]TJ 0 Tw /Span<>> BDC 25.126 0 Td (. . . . . . . . . . . . . . . . . .)Tj EMC -0.125 Tc 0.125 Tw 8.233 0 Td [(15)-75(2)]TJ 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0 Tc 0.023 Tw 10 0 0 10 42.5197 291.3598 Tm [(\037)62(\215\002)31(\222\013\001\025\r \b)-30.9(.\213., \255\215\002\007\016\026)11(\016\002 \004.\005., \214\020\n)10(\025\r \005.\030.)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0.195 Tw 13 0 0 13 42.5197 272.9252 Tm [(\027)42(\013\003\013\205\b\255\t)13.1(\220\003\214\n\211\201 \205\220\255, \220\006\006)11(\013\001\002\002\205\013\200\220\n\n\211\201 \006 \004\220\205\220\t\213\ )21.1(\013\205\215\013\n-\205\013\007\006\t\200\b\n\n\211\215 \004\205\013)10(\t)10(\b\002)]TJ 0 Tw (-)Tj 0.023 Tw T* [(\n\013\215 \(\013\203\013\205 \003\002\t)10(\b\205\220\t)-19.9(\005\205\211\))]TJ 0 Tw /Span<>> BDC [( )20.8( . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .\ . . . . . . . )0.7(. . . . . . .)]TJ EMC -0.1 Tc 0.1 Tw 33.321 0 Td [(16)-63(2)]TJ 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0 Tc 0.023 Tw 10 0 0 10 42.5197 239.6559 Tm [(\005\220\001\202)10(\013\222\025\r \b)-31(.\210., \021\215\n)10(\025\r \036.\030., \037)41(\013\007\013\001\025\r \214.\033)124.1(., \214\013\002\013\001\025\r\013 \032.\b)-31(., \b)20(\017\n\013\006\025\r \021.\030.)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf -0.033 Tw 13 0 0 13 42.5197 221.2214 Tm [(\f\205\b\007\002\255\t)10.1(\013\205\211 \n\b\203\003\220\213)21(\013\004\205\002\235\t\n\013\213)21.1(\013 \002\006\216\013\007\220 \t)10(\b\205\220\004\002\002 \255)20(\013\205)10(\t\002\255)19.9(\013\006\t)10.1(\b\205\013\002\007\220\215\002 \005 \004\220\001\002\b\n\t)10.1(\013\200 )]TJ 0.023 Tw T* [(\006 \t\235\206\b\003\013\201 \220\t)13(\220\255)20(\013\201 \235\200\b\n\n\013\213)21(\013 \255)20(\013\003\002\t)13(\220 \(\006\002\006\t)10.1(\b\215\220\t\002\207\b\006\255\002\201 \013\203\013\205 \002 \215\b\t)13(\220\220\n\220\003\002\))]TJ 0 Tw /Span<>> BDC 30.658 0 Td (. . . . . .)Tj EMC -0.112 Tc 0.112 Tw 2.688 0 Td [(17)-62(2)]TJ 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0 Tc 0.023 Tw 10 0 0 10 42.5197 187.9521 Tm [(\021\220\001\220\227\020\001 \033)123.9(.\037., \b)-21(\007\016\n\006\016\016\r \005.\004., \003\016\002\001\020\025\r \021.\004\ ., \033\020\f\013\n)10(\025\r \t.\031)72(.)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf -0.034 Tw 13 0 0 13 42.5197 169.5175 Tm [(\036\b)10(\013\004\220\006\n\013 \003\002 \013\006\t)13(\220\200\003\235\t\214 \205\220\n\005 \004\205\235\215\013\201 \255\002\222\ \255\002 \004\013\006\003\b \t\205\220\n\006\220\n\220\003\214\n\013\201\ \210\n\007\013\215\002\255\205\013)10(\216\002)]TJ 0 Tw (-)Tj 0.023 Tw T* [(\205\005\205\213\002\002 \013)10(\t\255\205\211\t)10(\013\201? \(\006\002\006\t)10(\b\215\220\t\002\207\b\006\255\002\201 \013\203\013\205 \002 \215\b\t)13(\220\220\n\220\003\002\))]TJ 0 Tw /Span<>> BDC 23.743 0 Td (. . . . . . . . . . . . . . . . . . . . . )Tj EMC -0.137 Tc 0.137 Tw 9.703 0 Td [(1)-12(81)]TJ ET 1 0.68 0 0.12 K q 1 0 0 1 42.5197 712.412 cm 0 0 m 453.543 0 l S Q BT /T1_0 1 Tf 0.06 Tc -0.06 Tw 17.5 0 0 17.5 208.7505 724.2505 Tm [(\021)31(\036)15(\255\t\033\223)-21(\b\213\030\t)]TJ /T1_3 1 Tf 0 Tc 0 Tw 25 0 0 25 519.3893 56.0378 Tm (7)Tj /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 23, \023\0221)69(, 202)69(4)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 23, \023\0221)69(, 202)69(4)]TJ ET endstream endobj 2657 0 obj <>/Border[0 0 0]/H/N/Rect[42.5197 671.636 496.063 656.348]/Subtype/Link/Type/Annot>> endobj 2658 0 obj <>/Border[0 0 0]/H/N/Rect[42.5197 623.532 472.454 608.245]/Subtype/Link/Type/Annot>> endobj 2659 0 obj <>/Border[0 0 0]/H/N/Rect[42.5197 607.933 496.063 592.645]/Subtype/Link/Type/Annot>> endobj 2660 0 obj <>/Border[0 0 0]/H/N/Rect[42.5197 571.829 471.678 556.541]/Subtype/Link/Type/Annot>> endobj 2661 0 obj <>/Border[0 0 0]/H/N/Rect[42.5197 556.229 496.063 540.941]/Subtype/Link/Type/Annot>> endobj 2662 0 obj <>/Border[0 0 0]/H/N/Rect[42.5197 520.125 471.844 504.837]/Subtype/Link/Type/Annot>> endobj 2663 0 obj <>/Border[0 0 0]/H/N/Rect[42.5197 504.525 496.063 489.237]/Subtype/Link/Type/Annot>> endobj 2664 0 obj <>/Border[0 0 0]/H/N/Rect[42.5197 438.648 496.063 423.36]/Subtype/Link/Type/Annot>> endobj 2665 0 obj <>/Border[0 0 0]/H/N/Rect[42.5197 372.771 496.063 357.483]/Subtype/Link/Type/Annot>> endobj 2666 0 obj <>/Border[0 0 0]/H/N/Rect[42.5197 336.667 468.535 321.379]/Subtype/Link/Type/Annot>> endobj 2667 0 obj <>/Border[0 0 0]/H/N/Rect[42.5197 321.067 496.063 305.779]/Subtype/Link/Type/Annot>> endobj 2668 0 obj <>/Border[0 0 0]/H/N/Rect[42.5197 284.963 464.882 269.675]/Subtype/Link/Type/Annot>> endobj 2669 0 obj <>/Border[0 0 0]/H/N/Rect[42.5197 269.363 496.063 254.075]/Subtype/Link/Type/Annot>> endobj 2670 0 obj <>/Border[0 0 0]/H/N/Rect[42.5197 233.259 467.48 217.971]/Subtype/Link/Type/Annot>> endobj 2671 0 obj <>/Border[0 0 0]/H/N/Rect[42.5197 217.659 496.063 202.371]/Subtype/Link/Type/Annot>> endobj 2672 0 obj <>/Border[0 0 0]/H/N/Rect[42.5197 181.555 464.882 166.267]/Subtype/Link/Type/Annot>> endobj 2673 0 obj <>/Border[0 0 0]/H/N/Rect[42.5197 165.955 496.063 150.667]/Subtype/Link/Type/Annot>> endobj 2690 0 obj <> endobj 2689 0 obj <> endobj 2688 0 obj <> endobj 2687 0 obj <> endobj 2686 0 obj <> endobj 2685 0 obj <> endobj 2684 0 obj <> endobj 2683 0 obj <> endobj 2682 0 obj <> endobj 2681 0 obj <> endobj 2680 0 obj <> endobj 2679 0 obj <> endobj 2678 0 obj <> endobj 2677 0 obj <> endobj 2676 0 obj <> endobj 2675 0 obj <> endobj 2674 0 obj <> endobj 2587 0 obj [2691 0 R 2692 0 R 2693 0 R 2694 0 R 2695 0 R 2696 0 R 2697 0 R 2698 0 R 2699 0 R 2700 0 R 2701 0 R 2702 0 R 2703 0 R 2704 0 R 2705 0 R 2706 0 R 2707 0 R 2708 0 R 2709 0 R] endobj 2588 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 0.01 Tc 0.018 Tw 13 0 0 13 70.931 687.8461 Tm [(\017)-32(\r)41(\037)31(\r\231\224)5( \t\004\213\207\n)43(\037)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0 Tc 0.023 Tw 10 0 0 10 70.8661 667.3422 Tm [(\021\020\017\016\r \021.\030., \033\020\f\013\n)10(\025\r \t.\031)72(., \b)-21(\007\016\n\006\016\016\r \005.\004., \003\016\002\001\020\025\r \021.\004\ ., \034\025\001\025\024\013\002\016\001\n)10(\025 \b)-31(.\b)-31(.)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.226 Tw 13 0 0 13 70.8661 648.9075 Tm [(\204\202\202\b\255\t\002\200\n\013\006\t\214 \t)10(\013)10(\t)13(\220\003\214\n\013\201 \n\b\013\220\007\236\230\200\220\n\t\n\013\201 \t\ )10(\b\205\220\004\002\002 \200 \003\b\207\b\n\002\002 \205\220\255\220 \004\ \205\235\215\013\201 )]TJ 0.023 Tw 0 -1.2 TD [(\255\002\222\255\002. \033)30(\b)10.1(\005)10(\003\214)21(\t)13(\220\t\211 \205\220\n\007\013\215\002\002\205\013\200\220\n\n\013\213)21.1(\013 \002\006\006\003\b\007\013\200\220\n\002\235)]TJ 0 Tw /Span<>> BDC 22.36 0 Td (. . . . . . . . . . . . . . . . . . . . . . . . .)Tj EMC -0.063 Tc 0.063 Tw 11.455 0 Td (10)Tj /T1_0 1 Tf 0.01 Tc 0.018 Tw -33.81 -2.072 Td [(\004\n\006\202\006\t\037)-20(\b\231\t\233\207)5( \017)-32(\r)41(\037)31(\r\231\006)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0 Tc 0.171 Tw 10 0 0 10 70.8661 585.8651 Tm [(\b\f\201\215\007\217\013\007\220\016\r\013 \235.\240)106(., \035\220\n\215)-20(\026)11(\025\r \b)-31(.\b)-31(., \004\016\006\016\007\025\r \004.\004., \005\026\r\002\013\007\013\r\220\ \007\220 \255.\b)-31(., \200\202)10(\013\203 \036.\005., \204\025\024\205\n)10(\025\r \t.\b)-31(., )]TJ 0.023 Tw 0 -1.2 TD [(\003\016\002\001\020\025\r \021.\004., \021\215\n)10(\025\r \036.\030.)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.101 Tw 13 0 0 13 70.8661 555.4305 Tm [(\204\n\007\013\006\255)20(\013\004\002\207\b\006\255\220\235 )0.5(\215\005\255)20(\013\210\255\t)10(\013\215\002\235 \006 \001\002\205\255\005)10(\003\235\205\n\211\215 \205\220\205\b)10(\013\215 \006\003\002\002\006\t)10(\013\201 \013\203\013\003\013\207\255\002 )]TJ 0.04 Tw 0 -1.2 TD [(\200\016)-39.6(\003\b\207\b\n\002\002 \013\004\005\216\013\003\b\201 )0.5(\013\203\013\007\013\207\n\013\201 )0.5(\255\002\222\255\002. \033)30(\b)10(\005)10(\003\214)21(\t)13(\220\t\211 \205\220\n\007\013\215\002\002\205\013\200\220\n\n\013\213)21(\013 \002\006\006\003\b)]TJ 0 Tw (-)Tj T* (\007\013\200\220\n\002\235)Tj /Span<>> BDC 3.46 0 Td [(. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . \ . . . . . . .)0.7( . . . . . . . . . . . . . . . . . . . . . . . )]TJ EMC -0.15 Tc 0.15 Tw 30.442 0 Td (21)Tj 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0 Tc 0.121 Tw 10 0 0 10 70.8661 506.5614 Tm [(\b)-21(\007\016\220\001 \255.\004., \b)20(\017\n\013\006\025\r \021.\030., \206\013\207\024\013\026)11.1(\025\r \255.\031)72(., \210\025\024\016\001\n)10.1(\025 \036.\200., \034\025\001\025\024\013\002\016\001\n)10.1(\025 \b)-31(.\b)-30.9(., \030\202\001\013\026)11(\016\001\n)10(\025 \005.\b)-31(., )]TJ 0.023 Tw T* [(\021\215\002\025\r\016\202\220\001 \t.\021., \021\215\n)10(\025\r \036.\030.)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.153 Tw 13 0 0 13 70.8661 476.1268 Tm [(\231\220\255\t)10(\013\205\211 \205\002\006\255\220 \220\200\013\205\013)10(\t)13(\220 \006\002\213)10(\215\013\200\002\007\n\013\201 \255\002\222\255\002 \005 \004\220\001\002\ \b\n\t)10(\013\200 \006 \002\007\002\013\004\220\t\002\207\b\006\255\002\215 )]TJ 0 Tw T* [(\215\b\213\220\255)20(\013\003\013\n/\215\b\213\220\205\b\255\t)-19.8(\005\215)]TJ /Span<>> BDC [( )167.1( . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .\ . . . . . . . )0.8(. . . . . . . . .)]TJ EMC -0.05 Tc 0.05 Tw 33.802 0 Td (32)Tj 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0 Tc 0.023 Tw 10 0 0 10 70.8661 442.8576 Tm [(\037)41(\013\024\013\016\r\013 \211.\211., \032)30(\220\026)11(\025\r \b)-31(.\200., \204\002\212\n\220\001 \033)124(.\200., \b\001\025\006\025\r \030.\021., \206\016\007\020\202\220\001 \200\ .\b)-31(.)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.34 Tw 13 0 0 13 70.8661 424.423 Tm [(\027)42(\013\n\t\205\013\003\002\205\005\b\215\220\235 \001\002\205\255\005)10(\003\235\205\n\220\235 \007\002\003\220\t)13(\220\001\002\235 \002 \203\013\255)20(\013\200\220\235 \004\013\007\255)20(\013\206\n\220\235 \006\202\002\n\255\t)10(\b\205\013)]TJ 0 Tw (-)Tj 0.179 Tw T* [(\t)10(\013\215\002\235\016)-178.6(\004\205\002 \003\b\207\b\n\002\002 \216\205\013\n\002\207\b\006\255\002\ \216 \220\n\220\003\214\n\211\216 \t\205\b\221\002\n \200 \006)11(\013\207\b\t)13(\220\n\002\002 \006 \213\b\215\013\205\205\013\b\215 )]TJ 0 Tw 0 -1.2 TD [(3\2374\016)-23.3(\006\t)13.1(\220\007\002\002)]TJ /Span<>> BDC 4.843 0 Td [(. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . \ . . . . . . .)0.7( . . . . . . . . . . . . . . . . . . . .)]TJ EMC -0.05 Tc 0.05 Tw 28.959 0 Td (42)Tj 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0 Tc 0.229 Tw 10 0 0 10 70.8661 375.5538 Tm [(\037)20(\220\026 \036.\030., \031)70(\016\r\025\002\n\205\001 \200.\b)-31(., \021\025\007\201\013\026\n\220\001\013 \213.\004., \037)31(\025\007\016\006\001\220\n)10.1(\025\r \t.\213., \031)70(\215\006\013\002\016\r\013 \005.\b)-31(., \214\025\001\201\013\002\016\001\n)10(\025 \036.\037., )]TJ 0.023 Tw 0 -1.2 TD [(\b\001\220\006\220\024\025\r \b)-31(.\t., \004\007\013\201\220\024\220\002\025\r\013 \035.\200.)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 13 0 0 13 70.8661 345.1192 Tm [(\033)30(\b)10(\005)10(\003\214)21(\t)13(\220\t\211 \205\b)10(\b\255\001\002\002 \004\205\235\215\013\201 \255\002\222\255\002 \004\205\ \002 \215\b\t)13(\220\006\t)13(\220\t\002\207\b\006\255)20(\013\215 \205\220\255\b)]TJ 0 Tw /Span<>> BDC 25.587 0 Td (. . . . . . . . . . . . . . . . . .)Tj EMC -0.05 Tc 0.05 Tw 8.215 0 Td (52)Tj 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0 Tc 0.023 Tw 10 0 0 10 70.8661 327.45 Tm [(\037)31(\025\006)-10(\026)11(\013\002\016\r \030.\004., \211\013\207)10(\013\002\205\001 \b)-31(.\004., \037)20(\220\006\016\007\016\r \255.\036., \214\007\013\202)10.1(\025\201\013\002\001\020\203 \035.\b)-31(., \005\215\201\002\025\r \b)-31(.\b)-31(., \032)30(\220\026)11(\025\r \b)-31(.\200.)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.051 Tw 13 0 0 13 70.8661 309.0154 Tm [(\f\235\t\002\003\b\t\n\002\201 )0.6(\013\004\211\t )0.5(\004\205\002\215\b\n\b\n\002\235 )0.6(\215\b\t)10(\013\007\220 )0.6(\003\220\b\205\n\013\201 )0.5(\255)20(\013\220\213)-21(\005)10(\003\235\001\002\002 )0.5(\004\205\002 \003\b\207\b\n\002\002 )0.5(\t\205\220\n\006- )]TJ 0.023 Tw T* [(\002 \210\255)21(\006\t\205\220\006\202\002\n\255\t)10(\b\205\n\211\216 \006\200\002\221\b\201 \004\205\235\215\013\201 \255\002\ \222\255\002)]TJ 0 Tw /Span<>> BDC 18.211 0 Td (. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .)Tj EMC 15.541 0 Td (59)Tj 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0.023 Tw 10 0 0 10 70.8661 275.7461 Tm [(\005\013\002\n\013\002\216\205\001 \255.\033)124.1(., \035\215\n\216\205\001\025\r \b)-30.9(.\005., \037)20(\220\006\016\007\016\r \255.\036., \b\202)10(\013\221\025\r \005.\b)-31(.)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.192 Tw 13 0 0 13 70.8661 257.3115 Tm [(\f\205\013\213\n\013 \006\t)10(\b\004\b\n\002 \004\013\200\205\b\206\007\b\n\002\201 \t)13(\220\013\200\013\213)21.1(\013 \007\n\220 \200 \003\b\207\b\n\002\002 \004\013\006\t)-29.9(\t\205\220\200\215\220\t\002\207\b\006\255)20(\013\213)21(\013 )]TJ 0.023 Tw T* [(\220\n\220\003\214\n\013\213)21.1(\013 \n\b\007\b\205\206\220\n\002\235)]TJ 0 Tw /Span<>> BDC 9.453 0 Td [(. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . \ . . . . . . . )0.7(. . . . . . . . . . )]TJ EMC -0.137 Tc 0.137 Tw 24.436 0 Td (71)Tj 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0 Tc 0.142 Tw 10 0 0 10 70.8661 224.0423 Tm [(\213\016\r\025\007\216\006\n\220\207 \b)-31(.\b)-30.9(., \214\002\025\201\006\n\220\203 \b)-31(.\033)124(., \b\r\201\016\016\001\n)10(\025 \004.\b)-31(., \034\025\017\215\016\r \032.\034., \005\220\207)10(\013\007\016\r\013 \200.\200., \214\016\002\016\222\025\r\006\n\013\205 \ \032.\034., )]TJ 0.023 Tw T* [(\211\220\f\220\002\025\r \033)124(.\210., \005\205\007\220\001\013 \021.\b)-31(., \036\002\016)21(\207\025\r \030.\b)-31(., \034\016\026\002\025\r \035.\036., \030\r\013\001\025\r \021.\b)-31(., \037)41(\013\221\002\220\001 \b)-31(.\255.)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.006 Tc 0.349 Tw 13 0 0 13 70.8661 193.6077 Tm [(\024)50.4(\205\220\n\006\220\n\220\003\214\n\211\b \210\n\007\013\215\002\255\205\013\ )10.4(\216\002\205\005\205\213\002\207\b\006\255\002\b \200\215\b\222\220\t)10.3(\b\003\214\006\t\200\220 \004\205\002 \205\220\255\b \004\205\235\215\013\ \201)6( )]TJ 0 Tc 0.023 Tw T* [(\255\002\222\255\002 \004\013\006\003\b \003\005)10(\207\b\200\013\201 \002\003\002 \216\002\215\002\013\003\005)10.1(\207\b\200\013\201 \t)10(\b\205\220\004\002\002\016)-23.2(\227 \n\230\220\n\006\211 \002 \205\b)10(\005)10(\003\214)21(\t)13(\220\t\211)]TJ 0 Tw /Span<>> BDC [( )182.2( . . . . . . . .)]TJ EMC -0.038 Tc 0.038 Tw 33.79 0 Td (82)Tj 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0 Tc -0.059 Tw 10 0 0 10 70.8661 160.3385 Tm [(\204\220\026)11(\013\002\216\205\001 \b)-31(.\031)72(., \b)-21(\201\220\222\025\r \021.\b)-31(., \b)-21(\007\220\f\016\n)10(\025\r \b)-31(.\211., \037)20(\220\006)-9.9(\007\205\n)10(\025\r \004.\213., \036\002\016)21(\207\025\r \b)-31(.\b)-31(., \204\220\026)11(\013\002\216\205\001 \004.\b)-31(., \036\221\007\220\024\013\207\022)58.6(\037.\021., )]TJ 0.023 Tw T* [(\031)80(\025\007\025\r\220\001\013 \b)-30.9(.\b)-31(.)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.152 Tw 13 0 0 13 70.8661 129.9039 Tm [(ICG-\220\n\213\002\013\213\205\220\202\002\235 \200 \013\001\b\n\255\b \255\ \220\207\b\006\t\200\220 \202\013\205\215\002\205\013\200\220\n\002\235 \ \004\013\003\n\013\006\003\013\201\n\013\213)21.1(\013 \004\205\235\215\013\255\002)]TJ 0 Tw (-)Tj 0.023 Tw T* [(\222\b\207\n\013\213)21(\013 \003\013\006\255\005)-21(\t)13(\220 \004\205\002 \013\004\b\205\220\t\002\200\n\013\215 \003\b\207\b\n\002\ \002 \006\003\013\206\n\211\216 \004\205\235\215\013\255\002\222\b\207\n\ \211\216 \006\200\002\221\b\201)]TJ 0 Tw /Span<>> BDC 31.58 0 Td (. . . . .)Tj EMC -0.112 Tc 0.112 Tw 2.284 0 Td (91)Tj ET 1 0.68 0 0.12 K q 1 0 0 1 70.8661 712.412 cm 0 0 m 453.543 0 l S Q BT /T1_1 1 Tf 0.06 Tc -0.06 Tw 17.5 0 0 17.5 237.097 724.2505 Tm [(\021)31(\036)15(\255\t\033\223)-21(\b\213\030\t)]TJ 0 Tc 0 Tw 7.5 0 0 7.5 70.8661 42.7216 Tm [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 23, \023\0221)69(, 202)69(4)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 23, \023\0221)69(, 202)69(4)]TJ /T1_3 1 Tf 25 0 0 25 34.6149 56.0378 Tm (6)Tj ET endstream endobj 2691 0 obj <>/Border[0 0 0]/H/N/Rect[70.8661 660.945 499.199 645.657]/Subtype/Link/Type/Annot>> endobj 2692 0 obj <>/Border[0 0 0]/H/N/Rect[70.8661 645.345 524.409 630.058]/Subtype/Link/Type/Annot>> endobj 2693 0 obj <>/Border[0 0 0]/H/N/Rect[70.8661 567.468 497.566 552.18]/Subtype/Link/Type/Annot>> endobj 2694 0 obj <>/Border[0 0 0]/H/N/Rect[70.8661 551.868 493.228 536.581]/Subtype/Link/Type/Annot>> endobj 2695 0 obj <>/Border[0 0 0]/H/N/Rect[70.8661 536.268 524.409 520.981]/Subtype/Link/Type/Annot>> endobj 2696 0 obj <>/Border[0 0 0]/H/N/Rect[70.8661 488.165 498.251 472.877]/Subtype/Link/Type/Annot>> endobj 2697 0 obj <>/Border[0 0 0]/H/N/Rect[70.8661 472.565 524.409 457.277]/Subtype/Link/Type/Annot>> endobj 2698 0 obj <>/Border[0 0 0]/H/N/Rect[70.8661 436.461 493.228 421.173]/Subtype/Link/Type/Annot>> endobj 2699 0 obj <>/Border[0 0 0]/H/N/Rect[70.8661 420.861 498.58 405.573]/Subtype/Link/Type/Annot>> endobj 2700 0 obj <>/Border[0 0 0]/H/N/Rect[70.8661 405.261 524.409 389.973]/Subtype/Link/Type/Annot>> endobj 2701 0 obj <>/Border[0 0 0]/H/N/Rect[70.8661 357.157 524.409 341.869]/Subtype/Link/Type/Annot>> endobj 2702 0 obj <>/Border[0 0 0]/H/N/Rect[70.8661 321.053 496.914 305.765]/Subtype/Link/Type/Annot>> endobj 2703 0 obj <>/Border[0 0 0]/H/N/Rect[70.8661 305.453 524.409 290.165]/Subtype/Link/Type/Annot>> endobj 2704 0 obj <>/Border[0 0 0]/H/N/Rect[70.8661 269.349 498.755 254.061]/Subtype/Link/Type/Annot>> endobj 2705 0 obj <>/Border[0 0 0]/H/N/Rect[70.8661 253.749 524.409 238.461]/Subtype/Link/Type/Annot>> endobj 2706 0 obj <>/Border[0 0 0]/H/N/Rect[70.8661 205.646 500.8 190.358]/Subtype/Link/Type/Annot>> endobj 2707 0 obj <>/Border[0 0 0]/H/N/Rect[70.8661 190.046 524.409 174.758]/Subtype/Link/Type/Annot>> endobj 2708 0 obj <>/Border[0 0 0]/H/N/Rect[70.8661 141.942 493.228 126.654]/Subtype/Link/Type/Annot>> endobj 2709 0 obj <>/Border[0 0 0]/H/N/Rect[70.8661 126.342 524.409 111.054]/Subtype/Link/Type/Annot>> endobj 2728 0 obj <> endobj 2727 0 obj <> endobj 2726 0 obj <> endobj 2725 0 obj <> endobj 2724 0 obj <> endobj 2723 0 obj <> endobj 2722 0 obj <> endobj 2721 0 obj <> endobj 2720 0 obj <> endobj 2719 0 obj <> endobj 2718 0 obj <> endobj 2717 0 obj <> endobj 2716 0 obj <> endobj 2715 0 obj <> endobj 2714 0 obj <> endobj 2713 0 obj <> endobj 2712 0 obj <> endobj 2711 0 obj <> endobj 2710 0 obj <> endobj 2448 0 obj <>/Font<>/ProcSet[/PDF/Text]/Properties<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 2449 0 obj <>/Font<>/ProcSet[/PDF/Text]/Properties<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 2450 0 obj <>/Font<>/ProcSet[/PDF/Text]>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 2451 0 obj <>/Font<>/ProcSet[/PDF/Text]>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 2452 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 2737 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 25 0 0 25 519.2769 56.0378 Tm (5)Tj /T1_1 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 23, \023\0221)69(, 202)69(4)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 23, \023\0221)69(, 202)69(4)]TJ ET 1 0.68 0 0.12 K 0.75 w q 1 0 0 1 42.5197 746.625 cm 0 0 m 136.063 0 l S Q q 1 0 0 1 42.5197 521.625 cm 0 0 m 136.063 0 l S Q q 1 0 0 1 42.5197 404.625 cm 0 0 m 136.063 0 l S Q q 1 0 0 1 42.5197 260.625 cm 0 0 m 136.063 0 l S Q BT /T1_2 1 Tf 0.023 Tw 7 0 0 7 42.5197 748.7008 Tm [(\037)-12(\036)-51.4(\035)-5.1(\034 \034 \033)-15.7(\032)-49.5(\031)-42.2(\032)18.8(\030)-5.1(\034)]TJ 0 0 0 1 k /GS1 gs /T1_3 1 Tf 0.023 Tc 0.153 Tw 6.3 0 0 6.3 42.5197 737.8661 Tm [(\037\036)-22.6(\035)6.8(\034)4.5(\033)23( \032)-26.3(\031)-16.3(\030)-2.3(\027)4.3(\026)-26.2(\035)4.8(\026)23( \253)12.7(\025)0.9(\024)-5.4(\035)2.5(\024)0.8(\023)6.6(\030)-6.3(\024)2.1(\022)-25.8(\021)-1.3(\024)-5.4(\035)2.5(\024)0.8(\020)-3.6(\017\016)7.3(\273)23( \016)6.8(\r)-14(\035\016)-1.5(\036)-11.3(\021)2.8(\f)-20.8(\016)23.1( \024)-2.7(\f)3.2(\r)-3.1(\036\013)-1.4(\036\027)6.4(\017)-3.3(\036)23( \f)7.2(\024)0.8(\r)6.5(\030)-10.4(\036)2.3(\n)0.5(\036\027)6.4(\027)6.4(\t)-7.2(\b)23( \021)-4.5(\036\027)-1.8(\007)-3.4(\036\027)]TJ 0 Tc 0 Tw 6.3 0 0 6.3 261.4045 737.8661 Tm (-)Tj 0.023 Tw 6.3 0 0 6.3 42.5197 729.8661 Tm [(\006)-23.8(\017)-16.6(\005)]TJ /Span<>> BDC ( )Tj EMC [(\017 \027)-18.7(\026)-23.9(\031)-39.3(\004)-16.2(\027)-22.2(\024)-40.1(-)-26.2(\023)-16.4(\030)-28.9(\026)-18.5(\022)-48.8(\021)-34.7(\017)-14(\004)-25.8(\036)-28(\f)-19.8(\022)-24.3(\017)-30.2(\b \007)-22.3(\024)-25.7(\f)-51.9(\021)-34.8(\017)-25.1(\032)-23(\036)-23.2(\027)-16.6(\017)-16.6(\005 \r \022)-18.9(\024)-28.4(\035)-20.5(\024)-17.5(\030)-33.3(\036)-23.2(\022)-48.8(\021)-38.4(\026)-49.2(\035)-16.2(\034)-18.5(\027)-22.2(\024)-22.2(\005 \b)-25.6(\017)-16.9(\030)-28.5(\031)-39.3(\030)-25.3(\020)-26.6(\017)-16.6(\017)-11.3(.)]TJ 0 Tw 0 -1.27 TD [(\003)-26.6(\026)-24.2(\002)-27.5(\024)-28.4(\035)-24.5(\036)-24.5(\r)-26.6(\026)-18.5(\027)-16.5(\017)-23.4(\016 )0.5(\021)-24.3(\024)-28.4(\035)-20(\f)-51.9(\021)-24.3(\024)-22.2(\005 )0.5(\022)-24.3(\017)-16.6(\001)-17.1(\022)-24.3(\017)-36(, )0.5()-27.5(\026)-39.7(\007)-23.8(\027)-25(\036)-24.4(\020)-20.2(\024 \023)-16.4(\030)-29.2(\024)-17.6(\b)-14.8(\024)-22(\007)-37(\026)-44.8(, )0.5(\021)-38.4(\026)-30.7()-22.9(\024)-22.2(\r)-22(\024)-22.2(\020)-20.2(\024 )0.5(\007)-23.8(\027)-18.7(\026 )0.5(\017 )0.5(\023)-16.4(\030)-29.3(\024)-18.4(\n)-22.5(\036)-36.5(\032)-25.7(\027)-22.2(\024)-25.7(\f)-51.9(\021)-34.8(\017 )0.5(\016)-16.2(\r)-36.9(\035)-22.9(\016)]TJ 6.3 0 0 6.3 261.4045 721.8661 Tm (-)Tj 0.191 Tw 6.3 0 0 6.3 42.5197 713.8661 Tm [(\033)-28.4(\021)-20.2(\f)-43.8(\016 \024)-22(\007)-23.8(\027)-16.6(\017)-15.8(\n)-15.8(\017 \017)-15.6( \027)-18.7(\026)-18.5(\017)-26.6(\002)-27.5(\024)-28.4(\035)-24.5(\036)-33.8(\036 \030)-28.9(\026)-18.2(\f)-19.8(\023)-16.4(\030)-29.3(\024)-25.7(\f)-51.9(\021)-45.2(\030)-28.9(\026)-18.5(\027)-25(\201)-23.2(\027)-16.5(\027)-16.6(\t)-30.2(\b)-52.6(, \026 \022)-18.8(\024)-28.4(\035)-20.5(\024)-22.2(\023)-16.4(\030)-29.3(\024)-20.9(\022)-48.8(\021)-24.3(\024)-28.4(\035)-20.5(\024)-22.2(\020)-26.6(\017)-23.4(\016)]TJ /Span<>> BDC ( )Tj EMC [(\227 \027)-18.7(\026)-18.5(\017)-26.6(\002)-27.5(\024)-28.4(\035)-24.5(\036)-33.8(\036 )]TJ 0.019 Tc 0.004 Tw T* [(\007)-4.8(\017)2.4(\027\026\n)3.2(\017)5(\004)2.8(\027)-3.1(\024)19( \030)-9.9(\026)-11.7()-1(\r\017)2.4(\r)-7.6(\026)0.5(\033)-2.4(\013)-5.4(\036)-4.2(\005)-1.4(\f)-24.8(\016)19( \b)-6.6(\017)2.1(\030)-9.5(\031)-20.3(\030)-6.3(\020)-7.6(\017)5(\004)-6.8(\036)-9(\f)-0.8(\022\024)-3.2(\005)19( \f)-0.8(\023)-6.8(\036)-4.2(\006)-4.8(\017\026)-30.2(\035)2.8(\034)0.6(\027)-3.2(\024)-6.7(\f)-32.9(\021)-15.8(\034)0.5(\033)16.9(.)]TJ 0 Tc -0.017 Tw T* [(\025)-22.1(\024)-28.4(\035)-20.5(\024)-17.5(\030)-33.4(\036)-23.2(\022)-48.8(\021)-38.4(\026)-49.2(\035)-16.1(\034)-18.5(\027)-16.6(\t)-16.6(\005 \030)-28.9(\026)-18.5(\022 )-27.5(\026)-18.5(\027)-16.6(\017)-15.8(\n)-17(\026)-24(\036)-34.3(\021 \024)-22(\007)-23.8(\027)-29.8(\031 \017)-15.6( \r)-26.1(\036)-36.1(\007)-59.7(\031)-28.9(\013)-24.3(\017)-30.1(\b \023)-21.8(\024)-10.7()-20(\017)-16.6(\006)-23.8(\017)-16.5(\005 \r \f)-51.9(\021)-45.2(\030)-28.5(\031)-28.8(\022)-48.8(\021)-66(\031)-39.3(\030)-33.4(\036 \024)-22.2(\027)-16.5(\022)-19(\024)-28.4(\035)-20.4(\024)-22.2(\020)-26.6(\017)-14(\004)-25.8(\036)]TJ 0 Tw 6.3 0 0 6.3 261.4045 697.8661 Tm (-)Tj 0.017 Tc 0.083 Tw 6.3 0 0 6.3 42.5197 689.8661 Tm [(\f)-2.8(\022)-7.3(\017)-13.2(\b)17( )-10.5(\026)-7.2(\002)-10.5(\024)-11.4(\035)-7.5(\036)-7.5(\r)-9.6(\026)-1.5(\027\017\005)-19(,)17( \027)-1.7(\026)-7.2(\002)-11.4(\035)0.8(\033)-5.5(\007)-20(\026)-7(\036)-17.3(\021)-3.1(\f)-26.8(\016)17( \027)-8(\036)-11.9(\031)-11.9(\022)-43.1(\035)-3.4(\024)-5.2(\027\027\t\005)17( \030)-12.2(\024)-8.7(\f)-35(\021)17.1( \r)-5(\024)-8.7(\f)-2.8(\023)-1.2(\026)-32.2(\035)0.8(\017)-13.7(\021)-10.4(\036)-28.6(\035)0.8(\034)-1.5(\027\t)-13.2(\b)17( )-10.5(\026)-7.2(\002)-10.5(\024)-11.4(\035)-7.5(\036)-7.5(\r)-9.6(\026)-1.5(\027\017\005)17( )]TJ 0.069 Tw T* [(\022)-7.3(\017\001)-9.8(\036)-8.2(\004)0.8(\027\017)0.5(\022)-19.1(\026)-27.8(,)17( \007)-6.8(\017\r)-9(\036)-2.9(\030)-16.4(\021)-17.7(\017\022)-30.9(\031)4.4(\035)-5.9(\016)2(\030)-8.3(\027)-5.2(\024)-5.2(\005)17( \002)-10.5(\024)-11.4(\035)-7.5(\036)-10.1()-3(\027\017)5.8(.)17( \215\024)-8.7(\f)-34.9(\021)-7.3(\024)-1.5(\016)0.8(\027\027)-5.2(\024)17( \017)1.3()-0.8(\n)-5.5(\036)-6.2(\027)-6.4(\016)0.8(\033)-11.3(\021)-3.2(\f)-26.8(\016)17( \007)-6.8(\017)-1.7(\026)-3(\020)-9.6(\027)-5.2(\024)-8.7(\f)-34.9(\021)-17.8(\017)3(\004)-8.7(\036)-11(\f)-2.9(\022)-7.2(\017)-9.3(\036)17( )]TJ 0 Tc 0.214 Tw T* [(\017 \035)-24.5(\036)-25.2(\004)-25.8(\036)-29.8(\002)-20.9(\027)-16.6(\t)-26.3(\036 \023)-21.8(\024)-22(\007)-55.5(\b)-14.8(\024)-22(\007)-23.8(\t \023)-16.4(\030)-25.3(\017 \035)-24.5(\036)-25.2(\004)-25.8(\036)-23.2(\027)-16.6(\017)-16.6(\017 \020)-23.4(\036)-20.7(\n)-18.4(\024)-17.5(\030)-11.6(\030)-29.3(\024)-22.2(\017)-24.8(\007)-37(\026)-49.2(\035)-16.2(\034)-18.4(\027)-22.2(\024)-22.2(\005 \002)-27.5(\024)-28.4(\035)-24.4(\036)-27.1()-20(\027)-16.6(\017)-36(, \f)-19.8(\r)-19.1(\017)-16.6(\013)-24.4(\036)-23.2(\005 )-27.5(\026)-39.7(\007)-23.8(\027)-25(\036)-24.5(\020)-20.2(\024 )]TJ 0.017 Tc 0.006 Tw T* [(\023)0.6(\030)-12.3(\024)-0.6(\b)2.2(\024)-5(\007)-20(\026)-27.8(,)17( \026)-1.5(\027)-1.6(\026)-32.2(\035)0.8(\034)-1.5(\027)-5.2(\024)-5.2(\005)17( \021)-28.2(\030)-16.4(\036)-6.2(\013)-7.3(\017\027)0.5(\t)-19(,)17( \026)-1.5(\027)-1.7(\026)-32.2(\035)0.8(\034)-1.5(\027)-5.2(\024)-5.2(\005)17( \017)0.5(\027\022)-1.9(\024)-5.2(\027)-13.7(\021)-17.8(\017\027)-8(\036)-6.2(\027\006)-6.8(\017\017)5.7(.)]TJ 0 Tc 0.016 Tw T* [(\025)-22.1(\024)-28.4(\035)-20.5(\024)-22.2(\023)-16.4(\030)-29.3(\024)-20.9(\022)-48.8(\021)-24.3(\024)-28.3(\035)-20.5(\024)-22.2(\020)-26.6(\017 \r \217)-9.7(\024)-25.7(\f)-15.2(\f)-19.8(\017)-16.6(\017)-36(, \022)-36.1(\026)-18.5(\022 \017 \r)-22(\024 \r)-20.7(\f)-18.9(\036)-20.7(\n \024)-25.7(\f)-51.9(\021)-38.4(\026)-49.2(\035)-16.2(\034)-18.4(\027)-22.2(\024)-18.4(\n \n)-15.8(\017)-16.9(\030)-33.4(\036)-37.3(, \017)-16.6(\027)-30.7(\021)-27.5(\036)-23.2(\027)-20.4(\f)-19.8(\017)-16.6(\r)-19.1(\027)-22.1(\024 \r)-18.5()-27.5(\026)-18.5(\017)-15.8(\n)-18.4(\024)-22(\007)-26.4(\036)-23.2(\005)]TJ 0 Tw 6.3 0 0 6.3 261.4045 657.8661 Tm (-)Tj 0.094 Tw 6.3 0 0 6.3 42.5197 649.8661 Tm [(\f)-51.9(\021)-34.8(\r)-24.4(\031)-28.9(\033)-28.4(\021 \f \024)-22.2(\027)-16.6(\022)-18.9(\024)-28.4(\035)-20.5(\024)-22.2(\020)-30.7(\026)-18.9(\n)-15.8(\017)-36(, \020)-30.7(\026)-18.2(\f)-51.9(\021)-45.2(\030)-29.3(\024)-11.6(\220)-22.2(\027)-30.7(\021)-27.5(\036)-19.8(\030)-29.2(\024)-28.5(\035)-20.4(\024)-22.2(\020)-30.7(\026)-18.9(\n)-15.8(\017)-36(, \024)-29.3(\002)-20.9(\013)-24.2(\017)-15.8(\n)-15.8(\017 \b)-25.6(\017)-16.9(\030)-28.5(\031)-39.3(\030)-25.3(\020)-30.7(\026)-18.9(\n)-15.8(\017)-36(, \220)-22.1(\027)-24.8(\007)-22.3(\024)-25.7(\f)-19.8(\022)-18.9(\024)-22.2(\023)-16.2(\017)-20.4(\f)-51.9(\021)-38.4(\026)-18.9(\n)-15.8(\017)-35.9(, )]TJ 0.016 Tc 0.236 Tw T* [(\023)-2.2(\026)-13.3(\021)-8.2(\024)-11.5(\235)-8(\017)-4(\017)-6.2(\024)-12.4(\035)-4.4(\024)-6.2(\020)-14.7(\026)-2.9(\n\017)16( \017)16( \f)-3.8(\023)-9.8(\036)-7.2(\006)-7.8(\017)-2.7(\026)-33.2(\035\017)-4.4(\f)-35.9(\021)-22.4(\026)-2.9(\n\017)16( \007)-9.5(\030)-12.5(\031)-12.8(\020)-10.6(\017)-14.2(\b)16( \027)-2.7(\026)-7.9(\031)-23.3(\004\027)-6.1(\024)-24.1(-)-10.2(\023\030)-12.9(\026)-2.5(\022)-32.8(\021)-18.7(\017)2(\004)-9.8(\036)-12(\f)-3.8(\022)-8.3(\017)-14.2(\b)16.1( \027)-2.6(\026)-4(\023\030)-12.9(\026)-4(\r)-21(\035)-8.5(\036)-7.2(\027\017)-0.6(\005)16( )]TJ 0.022 Tc 0.001 Tw T* [(\r)5.5(\030)-6.9(\026)11.7(\004)-3.8(\036)-7.8(\002)1.1(\027\024\005)22( \007)-4.4(\036)-12.7(\016)-8.2(\021)-5.4(\036)-23.6(\035)5.8(\034)3.5(\027\024)-3.7(\f)-29.9(\021)-12.8(\017)10.8(.)]TJ 0 Tc 0.146 Tw T* [(\037)-22.9(\036)-45.6(\035)-24.5(\036)-24.5(\r)-22(\024)-22.2(\005 )0.5(\026)-23.9(\031)-10.1(\007)-23.8(\017)-30.7(\021)-24.3(\024)-17.5(\030)-25.3(\017)-26.3(\036)-23.2(\005 )0.5(\032)-49.3(\031)-39.3(\030)-25.3(\027)-18.7(\026)-49.2(\035)-18.2(\026 \016)-16.1(\r)-37(\035)-22.9(\016)-16.2(\033)-28.4(\021)-20.2(\f)-43.8(\016 \022)-18.9(\024)-28.4(\035)-20.5(\024)-22.2(\023)-16.4(\030)-29.3(\024)-20.9(\022)-48.8(\021)-24.3(\024)-28.4(\035)-20.5(\024)-22.2(\020)-26.6(\017)-36(, )0.5(\026 \021)-38.4(\026)-18.5(\022)-51.1(\032)-23(\036 )0.5(\r)-16.6(\030)-28.8(\026)-10.3(\004)-16.2(\017 \007)-25.5(\030)-28.5(\031)-28.9(\020)-26.6(\017)-30.2(\b )]TJ 0.266 Tw T* [(\f)-19.8(\023)-25.8(\036)-23.2(\006)-23.8(\017)-18.7(\026)-49.2(\035)-16.2(\034)-18.4(\027)-22.2(\024)-25.7(\f)-51.9(\021)-27.5(\036)-23.2(\005)-36(, \017)-16.5(\027)-30.7(\021)-27.5(\036)-19.8(\030)-33.4(\036)-28(\f \022)-18.9(\024)-28.5(\021)-24.3(\024)-17.5(\030)-25.3(\t)-30.2(\b \f)-19.8(\022)-18.9(\024)-22.2(\027)-16.6(\006)-23.9(\036)-23.2(\027)-30.7(\021)-45.2(\030)-25.2(\017)-16.9(\030)-29.3(\024)-22.2(\r)-26.6(\026)-18.5(\027 \027)-18.7(\026 )-27.4(\026)-24.2(\002)-27.5(\024)-28.4(\035)-24.5(\036)-24.5(\r)-26.6(\026)-18.5(\027)-16.6(\017)-23.4(\016)-29.8(\b \021)-24.3(\024)-28.4(\035)-20(\f)-51.9(\021)-24.3(\024)-22.2(\005 )]TJ 0.023 Tw 0 -1.27 TD [(\022)-24.3(\017)-16.6(\001)-17.1(\022)-24.3(\017)-36(, )-27.4(\026)-39.7(\007)-23.8(\027)-25(\036)-24.5(\020)-20.2(\024 \023)-16.4(\030)-29.3(\024)-17.6(\b)-14.8(\024)-22(\007)-37(\026)-44.8(, \021)-38.4(\026)-30.7()-22.9(\024)-22.2(\r)-22(\024)-22.2(\020)-20.2(\024 \007)-23.8(\027)-18.7(\026 \017 \023)-16.4(\030)-29.3(\024)-18.4(\n)-22.5(\036)-36.5(\032)-25.7(\027)-22.2(\024)-25.7(\f)-51.9(\021)-34.8(\017)-11.3(.)]TJ 0.03 Tc 0.341 Tw 0 -1.27 TD [(\240)21.8(\031)-18.9(\030)-5(\027)1.7(\026)-28.9(\035)20.4( \253)10(\025)-1.7(\024)-8.1(\035\024)-1.9(\023)3.9(\030)-8.9(\024)-0.6(\022)-28.5(\021)-3.9(\024)-8.1(\035\024)-1.9(\020)-6.2(\017)3.7(\017)4.2(\273)20.3( \024)-9(\002)-7.6(\255)-14.9(\036)-15.7(\007)-3.5(\017)3.8(\027)-3.1(\016)-4.1(\036)-14(\021)20.4( \022)1.4(\024)-8.1(\035\024)-1.9(\023)4(\030)-9(\024)-0.6(\022)-28.4(\021)-4(\024)-8(\035\024)-1.9(\020\024)-1.9(\r)20.4( \217)10.5(\024)-5.3(\f)5.1(\f)0.6(\017)3.7(\017)20.3( \r)20.3( \021)-7.2(\036)-7.6(\f)0.5(\027)-1.8(\024)1.9(\n)30( )]TJ 0.016 Tc 0.01 Tw T* [(\f\024)-12.5(\021)-29.2(\030)-12.4(\031)5.9(\007)-7.8(\027)-0.6(\017)2(\004)-9.8(\036)-12(\f)-35.8(\021)-18.8(\r)-10.1(\036)16( \f)16( \023\030)-13.3(\024)-11.4(\235)-16(\036)-12(\f)0.8(\f)-3.8(\017)-6.2(\024)-6.2(\027)-2.6(\026)-33.2(\035\034)-2.5(\027)-0.6(\t\n\017)16.1( \024)-13.3(\002)-12(\255)-19.2(\036)-20.1(\007)-7.8(\017)-0.6(\027)-8.9(\036)-7.2(\027)-0.6(\017)-7.4(\016)0.7(\n\017)16( \n\017)-0.9(\030)-12.9(\026)16( \017)16( \r)-10.1(\036)-20.1(\007)-43.6(\031)-12.9(\013)-8.3(\017\n\017)16( \n)-6.5(\036)-20.5(\032)-35.9(\007)-43.7(\031)]TJ 0 Tc 0 Tw 6.3 0 0 6.3 261.4045 593.8661 Tm (-)Tj 0.023 Tw 6.3 0 0 6.3 42.5197 585.8661 Tm [(\027)-18.7(\026)-18(\030)-29.3(\024)-22(\007)-23.8(\027)-16.6(\t)-15.8(\n)-15.7(\017 \220)-20.9(\022)-19.8(\f)-19.8(\023)-25.8(\036)-19.8(\030)-33.4(\021)-38.4(\026)-18.9(\n)-15.8(\017 \r \024)-29.3(\002)-28.4(\035)-18.2(\026)-18.2(\f)-51.9(\021)-34.8(\017 \022)-18.9(\024)-28.4(\035)-20.5(\024)-17.5(\030)-33.4(\036)-23.2(\022)-48.8(\021)-38.3(\026)-49.2(\035)-16.2(\034)-18.5(\027)-22.2(\024)-22.2(\005 \b)-25.7(\017)-16.9(\030)-28.4(\031)-39.3(\030)-25.3(\020)-26.6(\017)-16.6(\017)-11.3(.)]TJ 0.336 Tw T* [(\200 \032)-49.2(\031)-39.3(\030)-25.3(\027)-18.7(\026)-49.2(\035)-24.5(\036 \023)-29.2(\031)-39.8(\002)-28.4(\035)-16.2(\017)-16.6(\022)-47.9(\031)-28.9(\033)-28.4(\021)-20.2(\f)-43.8(\016 \024)-17.5(\030)-25.3(\017)-16.6(\020)-26.6(\017)-16.6(\027)-18.7(\026)-49.2(\035)-16.2(\034)-18.4(\027)-16.6(\t)-26.3(\036 \f)-51.9(\021)-38.4(\026)-29.3(\021)-34.8(\034)-18.5(\017)-35.9(, \030)-33.4(\036)-27.1()-28.9(\031)-12.6(\035)-16.1(\034)12.3(\021)-38.4(\026)-29.3(\021)-34.8(\t \235)-27.1(\031)-28.8(\027)-24.8(\007)-37(\026)-18.9(\n)-22.5(\036)-23.2(\027)-30.7(\021)-38.4(\026)-49.2(\035)-16.2(\034)-18.5(\027)-16.5(\t)-30.2(\b )]TJ 0.028 Tc 0.405 Tw T* [(\017)-3.8(\f)1.4(\f)-38(\035)-7.9(\036)-19.5(\007)-5.7(\024)-5.5(\r)-10(\026)-1.9(\027\017\005)-19.3(,)16.6( \027)-2(\026)-3.4(\023\030)-12.3(\026)-3.4(\r)-20.3(\035)-7.9(\036)-6.6(\027\027\t)-9.7(\036)16.6( \027)-2(\026)16.6( \017)0.9()-12.2(\031)-22.7(\004)-9.2(\036)-6.6(\027\017)-9.7(\036)16.6( \024)-12.7(\002)-4.3(\013)-7.8(\036)-7.8(\023)-1.6(\026)-12.7(\021)-7.7(\024)-11.8(\035)-3.8(\024)-5.6(\020)-10(\017)2.6(\004)-9.1(\036)-11.4(\f)-3.2(\022)-7.7(\017)-13.5(\b)16.6( \023\030)-12.6(\024)-4.3(\006)-7.3(\036)-11.4(\f)1.4(\f)0.9(\024)-5.6(\r)28( )]TJ 0 Tc 0.072 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC [(\006)-23.9(\036)-45.6(\035)-16.2(\034)-18.5(\033 \031)-12.6(\035)-29.3(\031)-39.3(\004)-16.2(\001)-26.8(\036)-23.1(\027)-16.6(\017)-23.4(\016 \035)-24.5(\036)-25.2(\004)-25.8(\036)-23.2(\027)-16.6(\017)-23.4(\016 \002)-27.5(\024)-28.4(\035)-16.2(\034)-18.5(\027)-16.6(\t)-30.2(\b)-52.5(, \024)-22.2(\023)-16.1(\017)-20.4(\f)-30.2(\026)-18.5(\027)-16.6(\017)-26.3(\036 \022)-60.1(\035)-16.2(\017)-16.6(\027)-16.6(\017)-14(\004)-25.8(\036)-28(\f)-19.8(\022)-24.3(\017)-30.1(\b \027)-18.7(\026)-24.2(\002)-28.3(\035)-16.2(\033)-22.5(\007)-26.4(\036)-23.2(\027)-16.6(\017)-16.6(\005)-36(, \n)-22.5(\036)-34.3(\021)-38.4(\026)-28(-)]TJ 0.054 Tw T* [(\026)-18.5(\027)-18.7(\026)-49.2(\035)-16.2(\017)-15.7()-19.9(\t \017 \024)-29.3(\002)-11.2()-22.9(\024)-17.5(\030)-25.3(\t \035)-16.2(\017)-30.7(\021)-27.5(\036)-19.7(\030)-29(\026)-29.3(\021)-65.9(\031)-39.3(\030)-25.3(\t \023)-21.8(\024 \001)-17.1(\017)-16.9(\030)-29.3(\024)-20.9(\022)-18.9(\024)-18.4(\n)-22.5(\031 \f)-19.8(\023)-25.7(\036)-23.2(\022)-48.8(\021)-45.2(\030)-28.5(\031 \r)-22(\024)-22.2(\023)-16.4(\030)-29.3(\024)-25.7(\f)-15.8(\024)-22.2(\r \022)-18.9(\024)-28.4(\035)-20.5(\024)-22.2(\023)-16.4(\030)-29.3(\024)-20.9(\022)-48.8(\021)-24.2(\024)-28.4(\035)-20.5(\024)-22.2(\020)-26.6(\017)-16.6(\017)-36(, )]TJ 0.023 Tw 0 -1.27 TD (\026)Tj /Span<>> BDC ( )Tj EMC [(\021)-38.4(\026)-18.5(\022)-51.1(\032)-23(\036 \030)-33.4(\036)-27.1()-28.9(\031)-12.6(\035)-16.2(\034)12.3(\021)-38.4(\026)-29.3(\021)-34.7(\t \022)-60.1(\035)-16.2(\017)-16.6(\027)-16.6(\017)-14(\004)-25.8(\036)-28(\f)-19.8(\022)-24.3(\017)-30.1(\b \017 \220)-20.9(\022)-19.8(\f)-19.8(\023)-25.8(\036)-19.8(\030)-25.3(\017)-15.8(\n)-22.5(\036)-23.1(\027)-30.7(\021)-38.4(\026)-49.2(\035)-16.2(\034)-18.5(\027)-16.6(\t)-30.2(\b \017)-20.4(\f)-15.2(\f)-54.7(\035)-24.5(\036)-36.1(\007)-22.3(\024)-22.2(\r)-26.6(\026)-18.5(\027)-16.6(\017)-16.6(\005)-11.3(.)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.018 Tc 0.005 Tw 7 0 0 7 42.5197 523.7008 Tm [(\027)16.6(\035)0.5(\032\026)12.8(\025)13(\024)12(\023)18( \022)18.4(\036)-19.1(\031)-24.2(\032\021)-39.7(\020)-8.2(\017)4.4(\022)]TJ 0 0 0 1 k /GS1 gs 0.027 Tc 0.324 Tw 6.3 0 0 6.3 42.5197 512.8661 Tm [(\016)4.5(\r)-11(\f\013)-0.8(\n)-8.3(\t\b)25.7( \007)1(\006)-2.6(\t\005)25.6( \032)-4.2(\b)-3.1(\004)-8.3(\003)-6.6(\002)-4.2(\f\001)-6.4(\r)-5()2.7(\t)2.9(\201)25.6( \()21.2(\215)1.6(\002)-5.6(\217\220)-6()-2.8(\004)-7.5(,)25.7( \022)19.7(\002)-5.6(\217)7.6(\217\t)-6.4(\235)47.2(\))]TJ /T1_3 1 Tf 0.001 Tc 0.35 Tw /Span<>> BDC 22.802 0 Td ( )Tj EMC [(\227 \026)-18.9(\022)-36.4(\026)-40(\007)-26.7(\036)-21.1(\n)-16.1(\017)-16.9(\022 \217)18.8(\202)-17.8(\203)-30.9(, \007)-22.7(\024)-21.2(\022)-49.1(\021)-24.7(\024)-17.8(\030)1( )]TJ 0 Tc -0.014 Tw -22.802 -1.27 Td [(\n)-22.5(\036)-36.1(\007)-23.8(\017)-16.6(\006)-23.8(\017)-16.6(\027)-20.4(\f)-19.7(\022)-24.3(\017)-30.2(\b \027)-18.7(\026)-23.9(\031)-28.9(\022)-50.2(, \023)-16.4(\030)-29.3(\024)-27.5(\235)-32(\036)-28(\f)-15.2(\f)-15.7(\024)-17.5(\030)-21.3(, \235)-32(\036)-36.1(\007)-26.4(\036)-19.8(\030)-28.9(\026)-49.2(\035)-16.2(\034)-18.5(\027)-22.2(\024)-31.6(\036 \020)-20.2(\024)-25.7(\f)-50.6(\031)-10(\007)-37(\026)-18(\030)-27.5(\f)-51.9(\021)-34.8(\r)-26.1(\036)-23.2(\027)-16.6(\027)-22.2(\024)-31.6(\036 \002)-20.9(\033)-22.5(\007)-50.6(\032)-23(\036)-34.2(\021)-34.8(\027)-22.2(\024)-31.6(\036 \031)-39.3(\004)-16.4(\030)-33.4(\036)-36.5(\032)]TJ 0 Tw 6.3 0 0 6.3 261.4045 504.8661 Tm (-)Tj 0.017 Tc 0.061 Tw 6.3 0 0 6.3 42.5197 496.8661 Tm [(\007)-9.4(\036)-6.2(\027\017)-9.3(\036)17( \253)6.7(\203)3.8(\026)-1.5(\006)-6.8(\017)-5.2(\024)-5.2(\027)-1.7(\026)-32.2(\035)0.8(\034)-1.5(\027\t\005)17( \n)-5.5(\036)-19.1(\007)-6.8(\017)0.5(\006)-6.9(\017)0.5(\027)-3.4(\f)-2.8(\022)-7.3(\017\005)17( \017)-3.4(\f)1.8(\f)-37.7(\035)-7.5(\036)-19.1(\007)-5.3(\024)-5.2(\r)-9.6(\026)-12.3(\021)-10.5(\036)-28.6(\035)0.9(\034)-12.7(\f)-2.8(\022)-7.3(\017\005)17( \006)-6.9(\036)-6.2(\027)-13.7(\021)-28.2(\030)17( \022)-1.9(\024)-11.4(\035)-3.5(\024)-5.2(\023)0.7(\030)-12.3(\024)-3.9(\022)-31.8(\021)-7.3(\024)-11.4(\035)-3.5(\024)-5.2(\020)-9.6(\017\017)17( )]TJ 0.02 Tc 0.019 Tw 0 -1.27 TD [(\017)4.2(\n)-2.5(\036)-3.2(\027)3.4(\017)20.1( \202)-7.5(.)15(\203)14.2(.)]TJ /Span<>> BDC 4.73 0 Td ( )Tj EMC [(\217)4.9(\t)-5.2(\032)-5.7(\017)-10.2(\b)-23.3(\273)20( \204)4.8(\017)3.4(\027)3.4(\017\f)-31.9(\021)-7.5(\036\030)-7.5(\f)-31.9(\021)-14.8(\r)-6.6(\026)20( )-11.1(\007)-5.5(\030)-8.9(\026\r)-2(\024)-7.5(\024)2.4(\b)-13.4(\030)-8.9(\026)1.5(\027)-4.9(\036)-3.2(\027)3.4(\017)-3.4(\016)20( \217)10.2(\024)-5.7(\f)4.8(\f\017)3.4(\005\f\022)1.1(\024)-2.1(\005)20( \205)-10.7(\036)-16.1(\007)-6.4(\036\030)-8.9(\026)1.5(\006)-3.8(\017)3.4(\017)-16(,)20( )-7.5(\026\r)11.5(.)]TJ 0 Tc 0.156 Tw -4.73 -1.27 Td [(\022)-36.1(\026)-22.1(\235)-32(\036)-36.1(\007)-25.5(\030)-29.3(\024)-22.2(\005 \022)-18.9(\024)-28.4(\035)-20.5(\024)-22.2(\023)-16.4(\030)-29.3(\024)-20.9(\022)-48.8(\021)-24.3(\024)-28.4(\035)-20.5(\024)-22.2(\020)-26.6(\017)-16.6(\017 \205)-9.4(\206)-25.7(\207)-20.3(\210)-7.6(\211 \212)-16.7(\215)-16.3(\210 \217)-7.5(\204)-28.4(\202)-17.5(\203)-5.8(\215)-16.3(\210 \204)-15.2(\017)-16.6(\027)-15.7()-31.1(\007)-25.5(\030)-28.9(\026)-20(\r)-26.6(\026 \217)-9.8(\024)-25.7(\f)-14.7(c)-19.3(\017)-16.6(\017)-36(, \215)-11.3(\030)-33.4(\036)-27.1()-20(\017)-24.8(\007)-26.4(\036)-23.2(\027)-30.7(\021 )]TJ 0.03 Tc 0.334 Tw T* [(\210)-6.6(\002\013)-3.8(\036)0.7(\030)-8.7(\024)-5.2(\f)5.4(\f)0.7(\017)4(\005\f)0.7(\022)1.7(\024)-1.7(\005)20.6( \024)-8.7(\002\013)-3.8(\036)-7.4(\f)-31.4(\021)-14.2(\r)-5.6(\036)-2.6(\027)3.9(\027)-1.6(\024)-1.6(\005)20.5( )0.5(\024)3(\030)-4.7(\020)-10.2(\026)2.1(\027)4(\017)4.8()-6.9(\026)2(\006)-3.2(\017)3.9(\017)20.6( )0.5(\253)-19.2(\202)4(\f)5.3(\f)4.8(\024\006)-3.2(\017)1.9(\026)2(\006)-3.2(\017)-2.9(\016)20.6( )0.5(\022)1.6(\024)-7.8(\035\024)-1.6(\023)4.1(\030)-8.7(\024\022)-28.2(\021)-3.8(\024)-7.8(\035\024)-1.7(\020\024)-1.7(\r)30( )]TJ 0 Tc 0.123 Tw T* [(\217)-9.8(\024)-25.7(\f)-15.2(\f)-19.8(\017)-16.6(\017)-16.1(\273)-9.1(, )0.5(\215)-16.8(\024)-22(\004)-25.8(\036)-34.3(\021)-34.8(\027)-16.5(\t)-16.6(\005 )0.5(\004)-33.8(\035)-24.4(\036)-23.3(\027 )0.5(\213)-11.7(\r)-16.5(\030)-29.3(\024)-22.2(\023)-25.7(\036)-23.3(\005)-20.3(\f)-19.8(\022)-18.9(\024)-22.2(\020)-20.2(\024 )0.5(\024)-29.3(\002)-20.9(\013)-24.4(\036)-27.9(\f)-51.9(\021)-34.8(\r)-26.6(\026 )0.5(\022)-18.9(\024)-28.3(\035)-20.5(\024)-22.2(\023)-16.4(\030)-29.3(\024)-20.9(\022)-48.8(\021)-24.3(\024)-28.4(\035)-20.5(\024)-22.2(\020)-20.2(\024)-22.2(\r )0.6(\()-4.9(E)-38.4(S)-28.9(C)-18.9(P)0.5(\))-22.6(, )0.6(\020)-9.4(\035)-18.2(\026)-20(\r)]TJ 0 Tw 6.3 0 0 6.3 261.4045 464.8661 Tm (-)Tj 0.024 Tc 0.332 Tw 6.3 0 0 6.3 42.5197 456.8661 Tm [(\027)0.5(\t)0.6(\005)17.1( \r)-2(\027)-7.8(\036)-6.1(\001)-14(\021)-21.2(\026)-12.2(\021)-17.6(\027)0.5(\t)0.5(\005)17.2( \f)-2.6(\023)-8.7(\036)-6.1(\006)-6.6(\017)-1.6(\026)-32(\035)0.9(\017)-3.3(\f)-34.7(\021)24.1(-)-9(\022)-1.8(\024)-11.3(\035)-3.3(\024)-5.1(\023)0.7(\030)-12.1(\024)-3.8(\022)-31.7(\021)-7.1(\024)-11.3(\035)-3.4(\024)-5(\020)17.1( \204)1.9(\017)0.6(\027)0.5(\017)-3.3(\f)-34.7(\021)-10.4(\036)-2.6(\030)-10.4(\f)-34.8(\021)-17.6(\r)-9.5(\026)17.1( )-14.1(\007)-8.3(\030)-11.8(\026)-2.9(\r)-4.8(\024)-10.4(\024\b)-16.2(\030)-11.8(\026)-1.3(\027)-7.9(\036)-6.1(\027)0.6(\017)-6.3(\016)24( )]TJ 0 Tc 0.066 Tw T* [(\217)-28.4(\205)6(, \035)-18.2(\026)-23.9(\031)-39.3(\030)-33.4(\036)-22(\026)-29.3(\021 \023)-16.4(\030)-33.4(\036)-20.7(\n)-15.8(\017)-16.6(\017 \215)-11.4(\030)-28.9(\026)-20(\r)-19.1(\017)-30.7(\021)-27.5(\036)-45.6(\035)-16.2(\034)-29.7(\f)-51.8(\021)-34.8(\r)-26.6(\026 \217)-28.4(\205 \r)]TJ /Span<>> BDC ( )Tj EMC [(\024)-29.3(\002)-28.4(\035)-18.2(\026)-18.2(\f)-51.9(\021)-34.8(\017 \027)-18.7(\026)-23.9(\031)-28.9(\022)-24.3(\017 \017 \021)-27.5(\036)-41.6(\b)-25.6(\027)-16.6(\017)-16.6(\022)-24.3(\017)-36(, \215)-11.4(\030)-33.3(\036)-36.1(\007)-22.1(\f)-18.9(\036)-36.1(\007)-37(\026)-29.3(\021)-27.5(\036)-45.6(\035)-16.2(\034 )]TJ 0.022 Tc 0.001 Tw T* [(\007)-1.8(\017)1.6(\f)6.8(\f)3.1(\036)2.3(\030)-11.4(\021)-16.4(\026)3.5(\006)-1.8(\017\024\027)5.4(\027\024\020)1.9(\024)22( \f)6.2(\024\r)-4.1(\036)-12.3(\021)-16.4(\026)22( 2)4.9(0)-9.1(8)2.7(.)20.7(0)9.8(2)13.5(1)17.6(.)20.7(0)12.1(1)]TJ /T1_2 1 Tf 0.035 Tc -0.035 Tw 0 -1.72 TD [(S)16.4(P)13.2(I)18.2(N)7.4(-\220)5.2(\002)3.3(\240:)]TJ /T1_3 1 Tf -0.002 Tc 5.483 Tw /Span<>> BDC 4.481 0 Td ( )Tj EMC 1.368 0 Td [(79)-21.8(8)-16(9)-33.3(-)-34.9(8)-21.3(2)-12.7(2)-15.4(8)]TJ /Span<>> BDC 4.491 0 Td [( )4626.2( )]TJ EMC ( )Tj /T1_2 1 Tf 0.022 Tc 0.001 Tw 12.773 0 Td [(A)2.3(u)-1.9(t)-8.1(hor)22( I)5.2(D)-1.6(:)]TJ /T1_3 1 Tf 0.004 Tc 0.019 Tw 4.564 0 Td [( 4)-38.4(8)-27.1(0)-8.2(2)-5.9(59)]TJ /T1_2 1 Tf 0.017 Tc -0.017 Tw -27.677 -1.27 Td [(OR)1.6(C)-27.8(ID)-6.6(:)]TJ /T1_3 1 Tf 0.031 Tc -0.008 Tw /Span<>> BDC 3.027 0 Td ( )Tj EMC 2.823 0 Td [(0000)-9.9(-)-9.4(000)18.8(2)34.2(-)-1.9(8)-11.4(4)-11.4(80)-9.9(-)18.5(9)25.2(3)19(6)24.3(2)]TJ /Span<>> BDC 9.529 0 Td ( )Tj EMC 1.765 0 Td ( )Tj /Span<>> BDC ( )Tj EMC 5.714 0 Td ( )Tj /T1_2 1 Tf 0.007 Tc -0.007 Tw [(S)-23.4(C)-3.3(O)-10.1(PU)-14.8(S)-18(:)]TJ /T1_3 1 Tf -0.006 Tc 0.029 Tw 3.918 0 Td [( I)-15.9(D)-6( 57)-4.6(2)-14.5(1)-22.2(37)13.6(6)-30.3(0)-18.2(2)-19.4(8)-33(6)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0 Tc 0.023 Tw 7 0 0 7 42.5197 406.7008 Tm [(\033)-15.7(\032)-27(\215)-10.2(\036)-10.1(\255)-60.1(\020)-35.8(\034)-29.3(\020)-35.8(\036)-51.4(\035)-5.1(\034 \027)-1.4(\035)-17.5(\032)-17.9(\026)-5.2(\025)-13.6(\017)-13.6(\027)-12.4(\017 \022\036)-37(\031)-42.2(\032)-17.9(\021)-57.7(\020)-26.2(\017)-13.6(\022)27(\032)]TJ 0 0 0 1 k /GS1 gs 0.31 Tw 6.3 0 0 6.3 42.5197 395.8661 Tm [(\032)-7.5(\201)-27.7(\220)-45.3(\004)-26.9(\217)-17.6(\002)-29.2( \255)-24.1(\r)-25.4(\006)-30.2(\n)-27.2(\r)-28.3(\005 \034)-17.3()-28.5(\004)-27.7(\b)-28.3(\002)-29.2()-23(\t)-22.9(\201 \()-4.5(\215)-24(\002)-31.3(\217)-25.8(\220)-31.7()-28.5(\004)-33.1(, \022)-5.9(\002)-31.3(\217)-18.1(\217)-25.8(\t)-32.1(\235)21.6(\))]TJ /T1_3 1 Tf 0.024 Tc 0.286 Tw /Span<>> BDC ( )Tj EMC [(\227)24( \007)1.7(\024)3.1(\022)-24.8(\021\024)6.6(\030)23.9( \n)1.5(\036)-12.1(\007\017)7.4(\006\017)7.4(\027)3.6(\f)4.2(\022\017)-6.1(\b)24( \027)5.3(\026\031)-4.9(\022)-26.2(,)24( )]TJ 0 Tc 0.162 Tw 0 -1.27 TD [(\023)-16.4(\030)-29.3(\024)-27.5(\235)-32(\036)-28(\f)-15.2(\f)-15.8(\024)-17.5(\030)-21.2(, \004)-33.8(\035)-24.5(\036)-23.2(\027)-27.3(-)-26.2(\022)-18.9(\024)-17.5(\030)-11.6(\030)-33.4(\036)-28(\f)-19.8(\023)-21.8(\024)-22.2(\027)-24.8(\007)-26.4(\036)-23.2(\027)-30.7(\021 \217)19.1(\202)-17.4(\203)-30.6(, \007)-23.8(\017)-16.8(\030)-33.5(\036)-23.1(\022)-48.8(\021)-24.3(\024)-17.5(\030 \235)-31.9(\036)-36.1(\007)-26.4(\036)-19.8(\030)-28.9(\026)-49.2(\035)-16.2(\034)-18.5(\027)-22.2(\024)-22.2(\020)-20.2(\024 \020)-20.2(\024)-25.7(\f)-50.6(\031)-10.1(\007)-37(\026)-18(\030)-27.5(\f)-51.9(\021)-34.7(\r)-26.2(\036)-23.1(\027)-16.6(\027)-22.2(\024)]TJ 0 Tw 6.3 0 0 6.3 261.4045 387.8661 Tm (-)Tj 0.017 Tc 0.275 Tw 6.3 0 0 6.3 42.5197 379.8661 Tm [(\020)-3.2(\024)17( \002)-3.9(\033)-5.5(\007)-33.6(\032)-6(\036)-17.3(\021)-17.7(\027)-5.2(\024)-5.2(\020)-3.2(\024)17( \031)-22.3(\004)0.6(\030)-16.4(\036)-19.5(\032)-35(\007)-9.4(\036)-6.2(\027\017)-6.4(\016)17.1( \253)6.7(\203)3.7(\026)-1.5(\006)-6.8(\017)-5.2(\024)-5.2(\027)-1.7(\026)-32.2(\035)0.8(\034)-1.5(\027)0.5(\t\005)17( \n)-5.5(\036)-19.1(\007)-6.8(\017\006)-6.8(\017\027)-3.4(\f)-2.8(\022)-7.3(\017\005)17( \017)-3.4(\f)1.8(\f)-37.7(\035)-7.5(\036)-19.1(\007)-5.3(\024)-5.2(\r)-9.6(\026)-12.3(\021)-10.5(\036)-28.6(\035)0.8(\034)-12.7(\f)-2.8(\022)-7.3(\017\005)17( )]TJ 0.002 Tc 0.349 Tw T* [(\006)-23.8(\036)-23.1(\027)-30.6(\021)-45(\030 \022)-18.8(\024)-28.3(\035)-20.3(\024)-22.1(\023)-16.3(\030)-29.2(\024)-20.8(\022)-48.7(\021)-24.2(\024)-28.3(\035)-20.3(\024)-22.1(\020)-26.5(\017)-16.5(\017 \017)-15.7(\n)-22.4(\036)-23.1(\027)-16.5(\017 \202)-27.4(.)-4.9(\203)-5.8(.)]TJ /Span<>> BDC ( )Tj EMC [(\217)-15.1(\t)-25.1(\032)-25.5(\017)-30.1(\b)-43.2(\273 \204)-15.1(\017)-16.5(\027)-16.5(\017)-20.3(\f)-51.7(\021)-27.4(\036)-19.7(\030)-27.4(\f)-51.8(\021)-34.7(\r)-26.5(\026 )-31.1(\007)-25.4(\030)-28.8(\026)-19.9(\r)-21.8(\024)-27.4(\024)-17.5(\b)-33.3(\030)-28.8(\026)-18.4(\027)-24.9(\036)-23.1(\027)-16.4(\017)-23.3(\016)2( )]TJ 0 Tc 0.205 Tw T* [(\217)-9.8(\024)-25.7(\f)-15.2(\f)-19.8(\017)-16.6(\005)-20.3(\f)-19.9(\022)-18.9(\024)-22.1(\005 )0.5(\205)-30.7(\036)-36.1(\007)-26.4(\036)-19.8(\030)-28.9(\026)-18.5(\006)-23.8(\017)-16.6(\017)-35.9(, )0.5(\004)-33.8(\035)-24.5(\036)-23.2(\027 )0.6(\213)-11.7(\r)-16.5(\030)-29.3(\024)-22.2(\023)-25.8(\036)-23.2(\005)-20.4(\f)-19.8(\022)-18.9(\024)-22.2(\020)-20.2(\024 )0.6(\024)-29.3(\002)-20.9(\013)-24.4(\036)-28(\f)-51.9(\021)-34.8(\r)-26.6(\026 )0.6(\022)-19(\024)-28.4(\035)-20.4(\024)-22.2(\023)-16.4(\030)-29.3(\024)-20.9(\022)-48.8(\021)-24.3(\024)-28.4(\035)-20.5(\024)-22.2(\020)-20.2(\024)-22.2(\r )0.5(\()-4.9(E)-38.3(S)-28.9(C)-18.9(P)0.5(\))-22.6(, )]TJ 0.007 Tw T* [(\004)-33.8(\035)-24.5(\036)-23.2(\027 \023)-16.4(\030)-28.9(\026)-20(\r)-37(\035)-24.5(\036)-23.2(\027)-16.5(\017)-23.5(\016 \210)-27.1(\002)-20.9(\013)-24.4(\036)-19.7(\030)-29.3(\024)-25.7(\f)-15.2(\f)-19.8(\017)-16.6(\005)-20.4(\f)-19.8(\022)-18.9(\024)-22.2(\005 \024)-29.3(\002)-20.9(\013)-24.4(\036)-28(\f)-51.9(\021)-34.8(\r)-26.1(\036)-23.2(\027)-16.6(\027)-22.2(\024)-22.2(\005 \024)-17.5(\030)-25.3(\020)-30.7(\026)-18.5(\027)-16.6(\017)-15.6()-27.5(\026)-18.5(\006)-23.8(\017)-16.6(\017 \253)-39.7(\202)-16.6(\f)-15.2(\f)-15.8(\024)-20.9(\006)-23.8(\017)-18.7(\026)-18.5(\006)-23.8(\017)-23.4(\016 \022)-18.9(\024)-28.4(\035)-20.5(\024)]TJ 0 Tw 6.3 0 0 6.3 261.4045 355.8661 Tm (-)Tj 0.291 Tw 6.3 0 0 6.3 42.5197 347.8661 Tm [(\023)-16.4(\030)-29.3(\024)-20.9(\022)-48.8(\021)-24.3(\024)-28.4(\035)-20.5(\024)-22.2(\020)-20.2(\024)-22.1(\r \217)-9.7(\024)-25.7(\f)-15.2(\f)-19.8(\017)-16.6(\017)-16.2(\273)-9(, \214)-13.3(\026)-23.9(\031)-39.3(\030)-33.4(\036)-22(\026)-29.3(\021 \023)-16.4(\030)-33.4(\036)-20.6(\n)-15.8(\017)-16.6(\017 \215)-11.4(\030)-28.9(\026)-20(\r)-19.1(\017)-30.7(\021)-27.5(\036)-45.6(\035)-16.2(\034)-29.7(\f)-51.9(\021)-34.7(\r)-26.6(\026 \217)-9.8(\024)-25.7(\f)-15.2(\f)-19.8(\017)-16.6(\005)-20.4(\f)-19.8(\022)-18.9(\024)-22.2(\005 \205)-30.7(\036)-36.1(\007)-26.4(\036)-19.7(\030)-28.9(\026)-18.5(\006)-23.8(\017)-16.6(\017 )]TJ 0.023 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC [(\024)-29.3(\002)-28.4(\035)-18.2(\026)-18.2(\f)-51.9(\021)-34.7(\017 \027)-18.7(\026)-23.9(\031)-28.9(\022)-24.3(\017 \017 \021)-27.4(\036)-41.6(\b)-25.7(\027)-16.6(\017)-16.6(\022)-24.3(\017)]TJ /T1_2 1 Tf 0.035 Tc -0.035 Tw 0 -1.72 TD [(S)16.4(P)13.2(I)18.2(N)7.4(-\220)5.2(\002)3.3(\240:)]TJ /T1_3 1 Tf 0.007 Tc 0.964 Tw /Span<>> BDC 4.481 0 Td ( )Tj EMC 1.368 0 Td [(5)-24.1(4)-24.1(67)33.6(-)51.9(1)12(0)-16.8(62)]TJ /Span<>> BDC 4.375 0 Td [( )-4510.3( )]TJ EMC /T1_2 1 Tf 0.022 Tc 0.001 Tw 12.633 0 Td [(A)2.3(u)-1.9(t)-8.1(hor)22( I)5.2(D)-1.6(:)]TJ /T1_3 1 Tf -0.029 Tc 0.947 Tw /Span<>> BDC 4.564 0 Td ( )Tj EMC [(2)-33.4(6)-39.8(51)-25.3(4)-51.1(2)]TJ /T1_2 1 Tf 0.017 Tc -0.017 Tw -27.421 -1.27 Td [(OR)1.6(C)-27.8(ID)-6.6(:)]TJ /T1_3 1 Tf 0.031 Tc 1.568 Tw /Span<>> BDC 3.027 0 Td ( )Tj EMC 2.823 0 Td [(0000)-9.9(-)-9.4(000)21.1(1)48.7(-)18.5(9)19.8(2)16.7(9)5.7(4)-5.1(-)14.8(54)-14.5(4)46.9(7)]TJ /Span<>> BDC 9.461 0 Td ( )Tj EMC /T1_2 1 Tf 0.007 Tc -0.007 Tw 7.546 0 Td [(S)-23.4(C)-3.4(O)-10.1(PU)-14.9(S)-17.9(:)]TJ /T1_3 1 Tf -0.007 Tc 0.03 Tw /Span<>> BDC 3.662 0 Td ( )Tj EMC 2.052 0 Td [(I)-16.9(D)-7( 6)-25.9(6)-31.3(0)-11(3)-7.8(3)-34.1(49)-23.7(6)-39.9(4)-4.2(5)]TJ /T1_2 1 Tf 0 Tc 0.15 Tw -28.571 -3.07 Td [(Y)-29.2(v)-18.9(e)-23.6(s )0.5(P)-10.1(a)-21.5(n)-25.7(i)-21.4(s )0.5(\()-8.1(\200)-20(\004)-25.8(\006)-28.3(\t)-32.1(\202)-40.9(, )0.5(\203)-21.8(\006)-30.3(\004)-27.6(\b)-25.6(\204)-32.6(\t)-32.1(\235)21.6(\))]TJ /T1_3 1 Tf /Span<>> BDC ( )Tj EMC 14.186 0 Td [(\227 )0.5(\023)-16.4(\030)-29.3(\024)-27.5(\235)-31.9(\036)-28(\f)-15.2(\f)-15.8(\024)-17.5(\030)-21.2(, )0.5(U)-13.2(n)-21.9(i)-22.5(v)-26.5(e)-20.1(r)-37.8(s)-33.7(i)-23.8(t)-32.4(\351 )0.5(P)-18.4(a)-18.3(r)-63(i)-15.6(s )0.5(V)-43.8(I)-34.3(I)-44.3(, )0.6(P)-26.5(r)-23.8(o)-20.2(f)-36.1(e)-30.6(s)-30.2(s)-26.9(o)-20(r )0.5(o)-20.2(f )]TJ 0.231 Tw -14.186 -1.27 Td [(D)-37.8(i)-15.1(g)-22.4(e)-30.6(s)-36.9(t)-53.2(i)-22.5(v)-26.4(e S)-20.2(u)-15.8(r)-24.7(g)-22.4(e)-20.2(r)-67.2(y)-14.3(, )0.5(\003)-26.6(\026)-20(\r)-26.1(\036)-36.1(\007)-59.7(\031)-28.9(\033)-21.4(\013)-24.3(\017)-16.6(\005 \024)-28.5(\021)-14.9(\007)-26.3(\036)-45.6(\035)-24.5(\036)-23.2(\027)-16.6(\017)-26.3(\036)-20.7(\n )0.5(\022)-18.9(\024)-28.4(\035)-20.5(\024)-17.5(\030)-33.4(\036)-23.2(\022)-48.8(\021)-38.4(\026)-49.2(\035)-16.2(\034)-18.5(\027)-22.1(\024)-22.2(\005 \b)-25.7(\017)-16.8(\030)-28.5(\031)-39.3(\030)-25.3(\020)-26.6(\017)-16.6(\017 )0.5(B)-27(e)-21(a)-17.2(u)-21.6(j)-15.1(o)-17.4(n )]TJ 0.019 Tc 0.004 Tw 0 -1.27 TD [(ho)-4.7(s)1.5(p)-7.5(i)-4.8(t)-25.2(al)-47.8(,)19( \004)-14.7(\035)-5.5(\036)-4.2(\027)19( \213)7.3(\r)2.5(\030)-10.3(\024)-3.2(\023)-6.8(\036)-4.2(\005)-1.4(\f)-0.8(\022\024)-3.2(\005)19( \202)2.4(\f)3.8(\f)3.2(\024)-1.8(\006)-4.9(\017\026)0.5(\006)-4.8(\017)2.4(\017)19( \022\024)-9.4(\035)-1.5(\024)-3.2(\023)2.6(\030)-10.3(\024)-1.9(\022)-29.8(\021)-5.3(\024)-9.4(\035)-1.5(\024)-3.2(\020)-1.2(\024)-3.2(\r)]TJ /T1_2 1 Tf 0.017 Tc -0.017 Tw 0 -1.72 TD [(OR)1.6(C)-27.8(ID)-6.6(:)]TJ /T1_3 1 Tf 0.031 Tc 0.736 Tw /Span<>> BDC 3.027 0 Td ( )Tj EMC 2.823 0 Td [(0000)-9.9(-)-9.4(000)21.1(1)48.7(-)18.5(9)18.9(5)22.9(5)31.1(3)9.6(-)18.5(9)29.8(7)32.5(2)27.4(7)]TJ /Span<>> BDC 9.355 0 Td [( )-938.6( )]TJ EMC /T1_2 1 Tf 0.007 Tc -0.007 Tw [(S)-23.4(C)-3.4(O)-10.1(PU)-14.8(S)-18(:)]TJ /T1_3 1 Tf 0.004 Tc 0.763 Tw /Span<>> BDC 10.601 0 Td ( )Tj EMC [(I)-5.9(D)4( )743.7(3)8.6(527)5.9(5)-23.5(8)-23(6)-20.3(0)-31.7(4)-31.7(0)-27.1(0)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.005 Tc 0.018 Tw 7 0 0 7 42.5197 262.7008 Tm [(\017)-26.2(\020)-30.8(\026\036)-49.1(\020)-19.8(\255)-55(\020)-30.8(\026\036)-5.1(\025\025\024)-1(\023)5( \255)-11.5(\036)-5.1(\021)-16.6(\022)5.4(\036)-49.1(\020)16(\032)-12.8(\022)5.4(\205)]TJ 0 0 0 1 k /GS1 gs 0.028 Tc 0.324 Tw 6.3 0 0 6.3 42.5197 251.8661 Tm [(\022)14.2(\013)-7.1(\206)-5.8(\004)-1.3(\220)-4(\002)-3.2()25.9( )0.5(\036)5.7()3.5(\n)-1.3(\r)-2.8(\b\t\005)26( )0.5(\027)67(\r)-2.9(\b\b)-2.8(\004)-18.8(\240)-5.8(\001)-6.1(\r)-4.7()3(\t)3.1(\201)26( \()21.5(\215)1.9(\002)-5.3(\217\220)-5.7()-2.6(\004)-7.1(,)25.9( )0.5(\022)20.1(\002)-5.4(\217)7.8(\217\t)-6.2(\235)47.6(\))]TJ /T1_3 1 Tf 0.026 Tc 0.326 Tw /Span<>> BDC 23.653 0 Td ( )Tj EMC 0.585 0 Td [(\227)23.9( )0.5(\007)1.7(\024)3(\022)-24.9(\021\024)6.4(\030)24( )0.5(\n)1.4(\036)-12.1(\007\017)7.3(\006\017)7.3(\027)3.6(\f)4.1(\022\017)-6.3(\b)26( )]TJ 0.01 Tc 0.366 Tw -24.238 -1.27 Td [(\027)-18.5(\026)-23.7(\031)-28.7(\022)-49.9(, \023)-16.2(\030)-29.1(\024)-27.3(\235)-31.8(\036)-27.8(\f)-14.9(\f)-15.6(\024)-17.3(\030 \217)19.3(\202)-17.3(\203)-30.4(, \235)-31.8(\036)-35.9(\007)-26.2(\036)-19.6(\030)-28.7(\026)-48.9(\035)-16(\034)-18.3(\027)-22(\024)-31.4(\036 \020)-20(\024)-25.4(\f)-50.4(\031)-9.9(\007)-36.8(\026)-17.8(\030)-27.3(\f)-51.7(\021)-34.5(\r)-25.9(\036)-23(\027)-16.4(\027)-22(\024)-31.4(\036 \002)-20.7(\033)-22.3(\007)-50.4(\032)-22.8(\036)-34.1(\021)-34.6(\027)-21.9(\024)-31.4(\036 \031)-39.1(\004)-16.2(\030)-33.2(\036)-36.2(\032)-51.8(\007)-26.2(\036)]TJ 0 Tc 0 Tw 6.3 0 0 6.3 261.4045 243.8661 Tm (-)Tj 0.017 Tc 0.333 Tw 6.3 0 0 6.3 42.5197 235.8661 Tm [(\027\017)-9.6(\036)16.7( \253)6.4(\206)78.8(\024)-9(\f)-33.9(\031)6.6(\007)-20.3(\026)-1.3(\030)-10.7(\f)-35.2(\021)-18.1(\r)-9.4(\036)-6.5(\027\027\t\005)16.8( \027)-2(\026)-7.2(\031)-22.6(\004)0.6(\027\t\005)16.7( \006)-7.1(\036)-6.5(\027)-14(\021)-28.5(\030)16.7( \022)-2.1(\024)-11.7(\035)-3.8(\024)-5.5(\023\030)-12.6(\024)-4.2(\022)-32.1(\021)-7.6(\024)-11.7(\035)-3.8(\024)-5.4(\020)-9.9(\017\017)16.7( \017)0.9(\n)-5.7(\036)-6.5(\027\017)]TJ /Span<>> BDC 28.766 0 Td ( )Tj EMC [(\202)-10.7(.)11.7(\203)10.8(.)]TJ /Span<>> BDC 2.379 0 Td ( )Tj EMC [(\217)1.6(\t)-8.5(\032)-9(\017)-13.5(\b)-26.6(\273)17( )]TJ 0.033 Tc 0.321 Tw -31.145 -1.27 Td [(\204)13.6(\017)12.2(\027)12.3(\017)8.4(\f)-23.1(\021)1.4(\036)9(\030)1.3(\f)-23.1(\021)-6(\r)2.2(\026)28.9( )-2.3(\007)3.3(\030\026)8.8(\r)6.8(\024)1.3(\024)11.2(\b)-4.5(\030\026)10.3(\027)3.8(\036)5.7(\027)12.2(\017)5.4(\016)28.8( \217)19(\024)3.1(\f)13.7(\f)9(\017)12.2(\005)8.4(\f)9.1(\022)9.9(\024)6.6(\005)28.8( \205)-1.9(\036)-7.3(\007)2.4(\036)9.1(\030\026)10.3(\006)5(\017)12.2(\017)-7.1(,)28.8( \030\031\022)9.9(\024)6.6(\r)6.8(\024)6.8(\007)5(\017)-1.8(\021)1.3(\036)-16.8(\035)12.6(\034)28.9( \024\021)14(\007)2.4(\036)]TJ 0 Tc 0 Tw 6.3 0 0 6.3 261.4045 227.8661 Tm (-)Tj 0.019 Tc 0.333 Tw 6.3 0 0 6.3 42.5197 219.8661 Tm [(\035)-1.5(\026)16.7( \024)-5.5(\027\022)-2.2(\024)-5.5(\023\030)-12.6(\024)-4.2(\022)-32(\021)-7.6(\024)-11.7(\035)-3.8(\024)-5.5(\020)-9.9(\017\017)-19.2(,)16.7( \210)-27.1(\021)-18.1(\r)-9.4(\036)-17.5(\021)-3.5(\f)-35.2(\021)-18.1(\r)-9.4(\036)-6.5(\027\027\t\005)16.7( \f)-2.2(\036)-6.4(\022)-10.4(\030)-16.7(\036)-17.6(\021)-21.7(\026)-1.3(\030)-8.6(\034)16.8( \032)-32.6(\031)-22.6(\030)-8.6(\027)-1.9(\026)-32.5(\035)-1.5(\026)16.7( \253)6.4(\025)-5.3(\024)-11.7(\035)-3.8(\024)-5.5(\023\030)-12.6(\024)-4.2(\022)-32.1(\021)-7.5(\024)-11.7(\035)-3.8(\024)-5.5(\020)-9.9(\017)-6.7(\016)1(\273)7.8(,)19( )]TJ 0 Tc 0.189 Tw 0 -1.27 TD [(\004)-33.8(\035)-24.5(\036)-23.2(\027 \023)-16.4(\030)-28.9(\026)-20(\r)-37(\035)-24.5(\036)-23.2(\027)-16.6(\017)-23.4(\016 \202)-16.6(\f)-15.1(\f)-15.9(\024)-20.8(\006)-23.8(\017)-18.7(\026)-18.5(\006)-23.8(\017)-16.6(\017 \022)-18.9(\024)-28.4(\035)-20.5(\024)-22.2(\023)-16.4(\030)-29.3(\024)-20.9(\022)-48.8(\021)-24.2(\024)-28.5(\035)-20.4(\024)-22.2(\020)-20.2(\024)-22.2(\r \217)-9.8(\024)-25.7(\f)-15.2(\f)-19.8(\017)-16.6(\017)-36(, \023)-21.8(\024)-22.2(\023)-25.8(\036)-25.2(\004)-16.1(\017)-30.7(\021)-27.5(\036)-45.6(\035)-16.2(\034)-29.7(\f)-19.8(\022)-18.9(\024)-22.2(\020)-20.2(\024 \f)-15.8(\024)-22.2(\r)-26.1(\036)-34.3(\021)-38.4(\026 )]TJ 0.207 Tw T* [(E)-9.8(u)-15.9(r)-23.8(o)-16.5(p)-32.4(e)-21(a)-15.8(n S)-32.8(o)-24.8(c)-45.4(i)-19.2(e)-30.2(t)-57.7(y o)-20.2(f C)-24.3(o)-23.5(l)-28.8(o)-16.5(p)-21.8(r)-23.8(o)-24.7(c)-48.6(t)-29.7(o)-23.5(l)-28.7(o)-26.5(g)-41(y \()-4.9(E)-38.4(S)-28.9(C)-18.9(P)0.5(\))-22.6(, \214)-13.3(\026)-23.9(\031)-39.3(\030)-33.4(\036)-22(\026)-29.3(\021 \215)-11.4(\030)-33.4(\036)-20.7(\n)-15.8(\017)-16.6(\017 \215)-11.4(\030)-28.9(\026)-20(\r)-19.1(\017)-30.7(\021)-27.5(\036)-45.6(\035)-16.2(\034)-29.7(\f)-51.8(\021)-34.8(\r)-26.6(\026 \217)-28.4(\205 )]TJ 0.023 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC [(\024)-29.3(\002)-28.4(\035)-18.2(\026)-18.2(\f)-51.9(\021)-34.7(\017 \027)-18.7(\026)-23.9(\031)-28.9(\022)-24.3(\017 \017 \021)-27.4(\036)-41.6(\b)-25.7(\027)-16.6(\017)-16.6(\022)-24.3(\017)]TJ /T1_2 1 Tf 0.035 Tc -0.035 Tw 0 -1.72 TD [(S)16.4(P)13.2(I)18.2(N)7.4(-\220)5.2(\002)3.3(\240:)]TJ /T1_3 1 Tf -0.023 Tc 0.947 Tw /Span<>> BDC 4.481 0 Td ( )Tj EMC 1.368 0 Td [(9)-35.1(5)-26.6(9)-41.9(9)-54.3(-3)-23.8(3)-25.5(9)-47.7(0)]TJ /Span<>> BDC 4.423 0 Td [( )0.5( )-4557.3( )]TJ EMC /T1_2 1 Tf 0.022 Tc 0.001 Tw 12.585 0 Td [(A)2.3(u)-1.9(t)-8.2(hor)22( I)5.2(D)-1.6(:)]TJ /T1_3 1 Tf 0.024 Tc 0.894 Tw /Span<>> BDC 4.564 0 Td ( )Tj EMC [(6)17.3(7)43.6(606)20.5(3)]TJ /T1_2 1 Tf 0.007 Tc -0.007 Tw -27.421 -1.27 Td [(S)-23.4(C)-3.4(O)-10.1(PU)-14.9(S)-17.9(:)]TJ /T1_3 1 Tf 0 Tc 0.023 Tw /Span<>> BDC 3.662 0 Td ( )Tj EMC 2.187 0 Td [(I)-9.9(D 6)-18.9(6)-24.3(0)-12.2(2)-10.7(24)15.9(7)3.7(1)-7.6(5)6.4(7)]TJ ET /GS0 gs q 1 0 0 1 274.9606 746.625 cm 0 0 m 136.063 0 l S Q q 1 0 0 1 274.9606 521.625 cm 0 0 m 136.063 0 l S Q q 1 0 0 1 274.9606 404.625 cm 0 0 m 136.063 0 l S Q q 1 0 0 1 274.9606 260.625 cm 0 0 m 136.063 0 l S Q BT 1 0.68 0 0.12 k /T1_2 1 Tf 7 0 0 7 274.9606 748.7008 Tm [(A)-43.1(I)-18.8(M A)-17.9(N)-5.1(D S)-27(C)-6.9(O)-13.6(PE)]TJ 0 0 0 1 k /GS1 gs /T1_3 1 Tf 0.009 Tw 6.3 0 0 6.3 274.9606 737.8661 Tm [(T)-25.6(h)-23.1(e )0.5(p)-24.4(u)-15.9(r)-46.4(p)-30.1(o)-23.6(s)-30.6(e )0.5(o)-20.2(f )0.5(t)-33.8(h)-23.1(e )0.5(j)-15.1(o)-21.2(u)-15.9(r)-43.3(n)-16.1(a)-19.5(l )]TJ /T1_4 1 Tf 0.014 Tc -0.014 Tw 11.281 0 Td [(K)10.3(o)-3.3(lo)-3.4(p)-0.9(rok)-21.8(t)-1.1(o)-3.3(lo)-6.5(g)-16(i)3.2(a)]TJ /T1_3 1 Tf 0 Tc 0.009 Tw 6.452 0 Td [( )0.5(\()-4.9(R)-14.8(u)-29.7(s)-30.2(s)-33.7(i)-13.3(a)-15.9(n )0.5(J)-18.1(o)-21.3(u)-15.9(r)-43.3(n)-16.1(a)-19.5(l )0.6(o)-20.2(f )0.5(C)-24.3(o)-23.5(l)-28.8(o)-16.5(p)-21.8(r)-23.8(o)-24.7(c)-48.6(t)-29.7(o)-23.5(l)-28.7(o)-26.5(g)-41(y)10.5(\) )0.5(i)-15.6(s )0.5(t)-29.7(o )]TJ 0.02 Tc 0.003 Tw -17.734 -1.27 Td [(h)-2(i)4.9(g)2.8(h)2.5(l)-4.7(i)5(g)2.8(h)-5.2(t)20( cu)4.2(r)-27.8(r)-7(en)-5.1(t)20( t)-18.2(r)-7(en)-2.5(d)-12.4(s)20( a)4.1(n)-2.4(d)20( s)-5.6(c)-25.5(i)0.8(en)-5.1(t)-33.1(if)-49.5(i)6.7(c)20( a)0.8(c)1.6(h)-1.9(i)0.8(e)-3.8(v)-6.5(em)-4.5(en)-5.1(t)-35.8(s)20( i)8.4(n)20( c)5.3(o)-3.6(l)-8.7(or)-7(e)-7(c)-28.6(t)-24.2(a)0.5(l)20.1( s)3(u)4.1(r)-4.7(g)-2.4(er)-47.2(y)29.1(.)]TJ 0 Tc 0 Tw 0 -1.27 TD [(D)-37.8(i)-15.6(s)-30.6(e)-21(a)-34.2(s)-30.6(e)-30.5(s o)-20.2(f t)-33.7(h)-23.2(e c)-14.8(o)-23.5(l)-28.8(o)-17.4(n)-35.5(, a)-15.9(n)-15.9(u)-29.7(s)-45.3(, p)-32.4(e)-25.8(l)-13.8(v)-58.5(i)-13.3(c f)-54.1(l)-28.8(o)-26.5(o)-20(r)-4.1(, a)-15.9(n)-22.5(d p)-32.4(e)-20.2(r)-63(i)-11.6(n)-24(e)-22.1(u)-15.2(m a)-18.3(r)-27(e a)-17.8(m)-20.4(o)-17.4(n)-19.9(g t)-33.8(h)-23.1(e m)-20.4(o)-23.7(s)-36.9(t c)-14.7(o)-17.5(m)-14.3(m)-20.4(o)-17.4(n)1.9(; )]TJ 0.023 Tw T* [(a)-15.9(n)-22.5(d c)-14.8(o)-23.5(l)-28.8(o)-16.5(p)-21.8(r)-23.8(o)-24.6(c)-48.6(t)-29.7(o)-23.5(l)-28.8(o)-26.5(g)-41(y i)-15.6(s t)-33.8(h)-23(e m)-20.4(o)-23.7(s)-36.9(t d)-28.3(y)-35.1(n)-16.1(a)-17.8(m)-22.4(i)-13.3(c)-29.2(a)-19.4(l)-36(l)-16.6(y d)-23.3(e)-23.8(v)-26.5(e)-25.8(l)-28.8(o)-16.4(p)-26.5(i)-11.6(n)-19.9(g s)-17(u)-15.9(r)-24.7(g)-36.5(i)-13.3(c)-29.2(a)-19.5(l s)-17.5(p)-32.4(e)-27(c)-45.5(i)-13.4(a)-19.5(l)-23.3(t)-57.7(y)9.1(.)]TJ 0.012 Tc 0.432 Tw T* [(C)-24(o)-23.2(l)-28.4(o)-19.7(r)-26.7(e)-26.7(c)-48.3(t)-43.8(a)-19.2(l c)-28.9(a)-15.5(n)-17.8(c)-17.6(e)-19.9(r o)-24.4(c)-13.9(c)-19.8(u)-14.3(p)-26.1(i)-18.9(e)-30.3(s o)-17(n)-23.7(e o)-19.9(f t)-33.4(h)-22.8(e l)-31.2(e)-20.6(a)-20.8(d)-23.5(i)-11.3(n)-19.6(g p)-29.8(o)-23.4(s)-33.4(i)-23.5(t)-52.8(i)-14.8(o)-17.1(n)-19(s i)-11.3(n t)-33.5(h)-22.7(e s)-36.6(t)-38(r)-37.4(u)-14.4(c)-48.3(t)-29.9(u)-15.5(r)-26.7(e)12( )]TJ 0 Tc 0.049 Tw 0 -1.27 TD [(o)-20.2(f)]TJ /Span<>> BDC ( )Tj EMC [(o)-17.4(n)-18(c)-14.9(o)-23.4(l)-28.8(o)-26.5(g)-36.5(i)-13.3(c)-29.2(a)-19.5(l d)-23.8(i)-15.6(s)-30.6(e)-21(a)-34.2(s)-30.5(e)-30.6(s)-23.4(. T)-25.6(h)-23.1(e)-20.2(r)-27(e i)-15.6(s a s)-36.9(t)-32.3(e)-21(a)-21.1(d)-28.3(y i)-11.6(n)-18.1(c)-30.1(r)-27(e)-21(a)-34.2(s)-30.6(e i)-11.6(n i)-11.6(n)-21.5(f)-54.1(l)-45(a)-17.7(m)-14.5(m)-16.4(a)-26(t)-29.7(o)-20(r)-67.2(y b)-28.3(o)-16.5(w)-25.6(e)-25.8(l d)-23.8(i)-15.6(s)-30.6(e)-21(a)-34.2(s)-30.6(e)-30.6(s)-45.3(, )]TJ 0.023 Tw 0 -1.27 TD [(d)-23.8(i)-22.5(v)-26.5(e)-20.2(r)-66.3(t)-53.1(i)-13.3(c)-20.1(u)-16.6(l)-45(a)-18.3(r d)-23.8(i)-15.6(s)-30.6(e)-21(a)-34.1(s)-30.6(e)-36.8(, s)-36.9(t)-29.7(o)-17.4(m)-16.5(a p)-27.9(a)-26(t)-53.2(i)-19.2(e)-19.5(n)-25.1(t)-55.9(s)-23.4(.)]TJ 0.035 Tw T* [(D)-37.8(i)-13.4(a)-19(g)-17(n)-19.9(o)-23.7(s)-36.9(t)-53.2(i)-13.3(c a)-15.9(n)-22.5(d t)-38.3(r)-27(e)-21(a)-26(t)-33.8(m)-24.5(e)-19.5(n)-25.2(t o)-16.5(p)-29.7(t)-53.2(i)-15.1(o)-17.4(n)-19.3(s f)-32.9(o)-20(r h)-23.1(e)-19.6(m)-20.4(o)-20(r)-47.8(r)-36(h)-19(o)-20.6(i)-17(d d)-23.8(i)-15.6(s)-30.5(e)-21(a)-34.2(s)-30.6(e)-36.8(, a)-15.9(n)-16.1(a)-19.5(l f)-69.5(i)-15.6(s)-36.8(t)-30.2(u)-16.6(l)-45(a)-44.3(, a)-15.9(n)-16.1(a)-19.5(l f)-69.4(i)-15.6(s)-30.2(s)-17(u)-15.9(r)-27(e)-36.8(, )]TJ 0.023 Tw T* [(a)-15.9(n)-22.5(d a)-15.9(n)-16.1(a)-19.5(l i)-11.6(n)-18.1(c)-14.8(o)-17.4(n)-25.1(t)-53.2(i)-11.6(n)-24(e)-19.6(n)-18.1(c)-17.9(e a)-18.3(r)-27(e c)-14.8(o)-17.4(n)-19.3(s)-36.9(t)-44.2(a)-15.9(n)-25.1(t)-34.6(l)-16.6(y c)-18.2(h)-16.5(a)-15.9(n)-19.9(g)-36.5(i)-11.6(n)-19.9(g)-14.3(.)]TJ 0.348 Tw T* [(C)-24.3(o)-23.5(l)-28.8(o)-16.5(p)-21.8(r)-23.8(o)-24.7(c)-48.5(t)-29.7(o)-23.5(l)-28.8(o)-26.5(g)-36.5(i)-15.6(s)-36.9(t)-55.9(s i)-11.6(n R)-14.8(u)-29.7(s)-30.2(s)-33.7(i)-13.4(a)-44.3(, a)-34.2(s i)-11.6(n t)-33.8(h)-23.1(e r)-26.9(e)-30.6(s)-36.9(t o)-20.3(f t)-33.8(h)-23(e w)-21.5(o)-20(r)-39.9(l)-32.9(d)-42.5(, i)-11.5(n)-25.2(t)-32.3(e)-19.6(n)-19.3(s)-33.7(i)-22.5(v)-26.5(e)-25.8(l)-16.6(y i)-11.6(n)-25.1(t)-32.4(e)-20.2(r)-38.3(a)-19.2(c)-48.6(t )]TJ 0.046 Tc 0.774 Tw T* [(w)-28.9(it)-9.9(h)23.9( o)6.5(n)5.8(c)9.1(ol)-4.9(o)-2.6(g)-12.6(i)8.3(s)-13(t)-32(s)-21.4(,)23.9( g)7.6(a)-10.3(s)-13(t)-14.4(ro)-6.7(e)4.3(n)-1.2(t)-8.5(e)3.7(rol)-4.9(o)-2.6(g)-12.6(i)8.3(s)-13(t)-32(s)-21.4(,)23.9( )0.5(g)1.4(e)4.3(ne)3.7(r)-14.4(a)4.4(l)23.9( )0.5(s)6.9(u)8(r)-0.8(g)1.5(e)-4.9(o)6.5(n)4.6(s)-21.4(,)23.8( )0.5(e)4.3(n)1.4(d)4.6(os)-1.7(c)9.1(o)7.4(p)-2.6(i)8.3(s)-13(t)-32(s)-21.5(,)46.1( )]TJ 0 Tc -0.027 Tw T* [(p)-27.9(a)-26(t)-33.8(h)-19(o)-16.5(p)-23.9(h)-22.9(y)-36.5(s)-33.6(i)-15.1(o)-23.5(l)-28.8(o)-26.5(g)-36.5(i)-15.6(s)-36.9(t)-55.9(s)-45.3(, a)-15.9(n)-22.5(d s)-17.4(p)-32.4(e)-27(c)-45.5(i)-13.4(a)-19.5(l)-24.7(i)-15.6(s)-36.9(t)-55.9(s i)-11.6(n o)-23.8(t)-33.8(h)-23.1(e)-20.2(r s)-25.6(c)-45.4(i)-19.2(e)-19.6(n)-25.1(t)-53.2(i)-20.2(f)-69.5(i)-13.3(c a)-15.9(n)-22.5(d p)-21.8(r)-38.2(a)-19.3(c)-48.6(t)-53.2(i)-13.3(c)-29.2(a)-19.5(l a)-18.3(r)-26.9(e)-21(a)-34.2(s o)-20.2(f)]TJ /Span<>> BDC ( )Tj EMC [(m)-24.5(e)-28.8(d)-23.8(i)-13.3(c)-29.2(a)-19.5(l )]TJ -0.009 Tc 0.009 Tw T* [(a)-28.3(c)-57.6(t)-62.2(i)-31.5(v)-67.6(i)-32.8(t)-66.7(y.)]TJ 0 Tc 0.07 Tw 0 -1.27 TD [(T)-25.6(h)-23.1(e t)-44.1(a)-18.3(r)-24.7(g)-22.4(e)-30.2(t a)-17.2(u)-18.6(d)-23.8(i)-19.2(e)-19.6(n)-18(c)-17.9(e o)-20.2(f t)-33.7(h)-23.2(e j)-15.1(o)-21.3(u)-15.9(r)-43.3(n)-16.1(a)-19.5(l i)-15.6(s c)-14.8(o)-23.5(l)-28.8(o)-16.5(p)-21.8(r)-23.7(o)-24.7(c)-48.6(t)-29.7(o)-23.5(l)-28.8(o)-26.5(g)-36.5(i)-15.6(s)-36.9(t)-55.9(s)-45.3(, a)-34.2(s w)-25.6(e)-25.8(l)-35.9(l a)-34.2(s d)-19.3(o)-24.7(c)-48.6(t)-29.7(o)-20(r)-37.7(s o)-20.2(f o)-23.8(t)-33.8(h)-23.1(e)-20.2(r )]TJ 0.033 Tw 0 -1.27 TD [(s)-17.5(p)-32.4(e)-27(c)-45.5(i)-13.4(a)-19.5(l)-23.2(t)-53.2(i)-19.2(e)-30.6(s)-45.3(, w)-25.6(h)-19(o)-23.7(s)-30.6(e i)-11.5(n)-25.2(t)-32.3(e)-20.2(r)-27(e)-30.6(s)-36.9(t i)-15.6(s f)-32.8(o)-24.7(c)-20.1(u)-29.7(s)-30.6(e)-28.8(d o)-17.4(n d)-23.8(i)-15.6(s)-30.6(e)-20.9(a)-34.3(s)-30.5(e)-30.6(s o)-20.2(f t)-33.8(h)-23.1(e c)-14.7(o)-23.6(l)-28.7(o)-17.4(n)-35.5(, r)-27(e)-27(c)-48.6(t)-30.2(u)-15.2(m)-36(, a)-16(n)-15.9(u)-29.6(s)-45.3(, p)-32.4(e)-25.8(l)-13.8(v)-58.6(i)-13.3(c )]TJ 0.023 Tw T* [(f)-54.1(l)-28.8(o)-26.5(o)-20(r a)-15.8(n)-22.5(d p)-32.4(e)-20.2(r)-63.1(i)-11.6(n)-24(e)-22.1(u)-15.2(m)-14.4(.)]TJ 0.017 Tc 0.623 Tw T* [(T)-25.7(h)-23.2(e j)-15.2(o)-21.4(u)-16(r)-43.4(n)-16.2(a)-19.7(l )]TJ /T1_4 1 Tf 0.031 Tc -0.031 Tw [(K)10.2(o)-3.4(lo)-3.5(p)-1(rok)-22(t)-1.2(o)-3.4(lo)-6.6(g)-16.1(i)3(a)]TJ /T1_3 1 Tf 0.041 Tc 0.599 Tw 13.105 0 Td [( \()19(R)9.1(u)-5.8(s)-6.3(s)-9.8(i)10.5(a)8(n)23.9( J)5.8(o)2.6(u)8(r)-19.4(n)7.8(a)4.4(l)23.9( o)3.7(f)23.9( Col)-4.9(o)7.4(p)2.1(ro)-0.8(c)-24.7(t)-5.8(ol)-4.9(o)-2.6(g)-17.1(y)34.4(\))23.9( u)10.6(n)2(it)-8.5(e)-6.7(s)41( )]TJ 0 Tc 0.238 Tw -13.105 -1.27 Td [(c)-14.8(o)-23.5(l)-28.8(o)-16.5(p)-21.8(r)-23.8(o)-24.7(c)-48.6(t)-29.6(o)-23.5(l)-28.8(o)-26.5(g)-36.5(i)-15.6(s)-36.9(t)-55.9(s o)-20.2(f R)-14.8(u)-29.7(s)-30.2(s)-33.7(i)-13.4(a i)-11.6(n c)-22.4(l)-28.8(o)-23.7(s)-30.6(e c)-14.8(o)-26.5(o)-16.5(p)-32.4(e)-20.2(r)-38.3(a)-26(t)-53.2(i)-15.1(o)-17.4(n w)-52.8(i)-23.8(t)-33.8(h p)-21.8(r)-23.8(o)-20.2(f)-36.1(e)-30.6(s)-30.1(s)-33.7(i)-15.1(o)-17.4(n)-16.1(a)-19.5(l a)-34.2(s)-30.2(s)-26.9(o)-24.7(c)-45.5(i)-13.4(a)-26(t)-53.2(i)-15.1(o)-17.4(n)-19.3(s )]TJ 0.023 Tw T* [(o)-20.2(f t)-33.8(h)-23.1(e w)-21.5(o)-20(r)-40(l)-32.9(d a)-15.9(n)-22.5(d l)-31.5(e)-21(a)-21(d)-23.8(i)-11.6(n)-19.9(g i)-11.6(n)-25.1(t)-32.4(e)-20.2(r)-43.3(n)-16.1(a)-26(t)-53.2(i)-15.1(o)-17.4(n)-16.1(a)-19.5(l e)-40.6(x)-32.4(p)-32.4(e)-20.2(r)-66.3(t)-55.9(s i)-11.6(n t)-33.8(h)-23.1(e f)-69.5(i)-19.2(e)-25.8(l)-32.8(d o)-20.2(f c)-14.8(o)-23.5(l)-28.8(o)-20(r)-27(e)-27(c)-48.6(t)-44.2(a)-19.4(l s)-17(u)-15.9(r)-24.7(g)-22.4(e)-20.2(r)-67.2(y)9.2(.)]TJ 0.01 Tc 0.349 Tw T* [(T)-25.6(h)-23.1(e j)-15.1(o)-21.3(u)-15.9(r)-43.3(n)-16.1(a)-19.5(l p)-24.4(u)-21.5(b)-26.1(l)-24.7(i)-15.6(s)-17(h)-23(e)-30.6(s o)-20(r)-63.1(i)-15.1(g)-36.5(i)-11.6(n)-16.1(a)-19.5(l a)-18.3(r)-66.3(t)-53.2(i)-13.3(c)-22.4(l)-31.5(e)-30.6(s)-45.3(, t)-33.8(h)-23.1(e r)-26.9(e)-30.6(s)-17(u)-16.6(l)-23.3(t)-55.9(s o)-20.2(f b)-25.6(a)-34.2(s)-33.7(i)-13.3(c r)-27(e)-30.6(s)-30.6(e)-21(a)-18.3(r)-19.6(c)-18.3(h a)-23(i)-11.5(m)-24.5(e)-28.8(d)10( )]TJ 0.212 Tw T* [(a)-26(t)]TJ /Span<>> BDC ( )Tj EMC [(s)-36.9(t)-30.2(u)-18.6(d)-28.3(y)-54.6(i)-11.6(n)-19.9(g g)-22.4(e)-19.6(n)-24(e)-20.2(r)-38.3(a)-19.5(l p)-27.9(a)-26(t)-33.8(h)-19(o)-23.5(l)-28.8(o)-26.5(g)-36.5(i)-13.3(c)-29.2(a)-19.5(l p)-21.8(r)-23.8(o)-24.7(c)-17.9(e)-30.6(s)-30.2(s)-30.6(e)-30.6(s i)-11.6(n o)-20(r)-26(d)-23.4(e)-20.2(r t)-29.7(o i)-11.6(m)-13.4(p)-21.8(r)-23.8(o)-18.4(v)-26.5(e t)-33.8(h)-23.1(e t)-38.3(r)-27(e)-21(a)-26(t)-33.8(m)-24.5(e)-19.6(n)-25.1(t)10( )]TJ 0.063 Tw 0 -1.27 TD [(o)-20.2(f)]TJ /Span<>> BDC ( )Tj EMC [(p)-27.9(a)-26(t)-53.2(i)-19.2(e)-19.6(n)-25.1(t)-55.9(s)-45.3(, c)-22.5(l)-24.7(i)-11.5(n)-21.9(i)-13.3(c)-29.2(a)-19.5(l c)-29.2(a)-34.2(s)-30.6(e)-30.6(s)-45.3(, m)-24.5(e)-30.2(t)-44.2(a)-27.5(-)-21.1(a)-15.9(n)-16.1(a)-19.5(l)-16.6(y)-36.5(s)-30.6(e)-30.6(s)-45.3(, a)-15.9(n)-22.5(d l)-24.7(i)-23.8(t)-32.4(e)-20.2(r)-38.3(a)-26(t)-30.2(u)-15.9(r)-27(e r)-27(e)-23.8(v)-58.6(i)-19.2(e)-20.6(w)-33.3(s o)-17.4(n a w)-52.8(i)-17(d)-23.3(e r)-38.3(a)-15.9(n)-19.9(g)-22.4(e)10( )]TJ 0.278 Tw 0 -1.27 TD [(o)-20.2(f)]TJ /Span<>> BDC ( )Tj EMC [(c)-14.8(o)-23.5(l)-28.8(o)-16.5(p)-21.8(r)-23.8(o)-24.7(c)-48.6(t)-29.7(o)-23.5(l)-28.8(o)-26.5(g)-41(y i)-15.6(s)-30.2(s)-17(u)-20.6(e)-30.6(s)-45.3(, a)-34.2(s w)-25.6(e)-25.8(l)-36(l a)-34.2(s t)-33.8(h)-23.1(e r)-27(e)-30.6(s)-17(u)-16.6(l)-23.3(t)-55.9(s o)-20.2(f c)-22.4(l)-24.7(i)-11.6(n)-21.9(i)-13.3(c)-29.2(a)-19.5(l a)-15.9(n)-22.5(d e)-40.6(x)-32.4(p)-32.4(e)-20.2(r)-63.1(i)-11.5(m)-24.6(e)-19.6(n)-25.1(t)-44.1(a)-19.6(l)10.1( )]TJ 0.029 Tc -0.029 Tw T* [(s)-17.9(t)-11.2(ud)-4.7(ie)-11.6(s)-4.4(.)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.01 Tc 0.013 Tw 7 0 0 7 274.9606 523.7008 Tm [(C)-6.5(H)-3.8(I)-3.4(EF)10( EDI)-44.1(T)-16.2(O)-3.6(R)]TJ 0 0 0 1 k /GS1 gs 0 Tc 0.162 Tw 6.3 0 0 6.3 274.9606 512.8661 Tm [(Y)1.2(u)-23(r)-59.2(i \032)-42.9(.)]TJ /Span<>> BDC ( )Tj EMC [(S)-22.9(h)-22.8(e)-24.6(l)-11.1(y)-19.4(g)-42.4(i)-20.1(n \()-4.5(M)-21(o)-20(s)-27.5(c)-14.4(o)-18(w)4.3(, R)-18.7(u)-23(s)-25.2(s)-35.6(i)-21(a)19.7(\))]TJ /T1_3 1 Tf /Span<>> BDC ( )Tj EMC [(\227 D)-22.4(r)21.2(. o)-20.2(f S)-31(c)-45.5(i)-8.7(. \()2.8(M)-20.7(e)-28.8(d)-19.9(.)33.4(\))-22.6(, P)-26.5(r)-23.8(o)-20.2(f)-36.1(e)-30.5(s)-30.2(s)-26.9(o)-20(r)-4.1(, a)-19.3(c)-29.2(a)-21.1(d)-23.3(e)-19.6(m)-22.4(i)-13.3(c)-45.5(i)-13.4(a)-15.9(n )]TJ 0.271 Tw T* [(o)-20.2(f R)-51(A)-47.8(S)-38.7(, R)-37.9(y)-41.4(z)-20.6(h)-22(i)-14.8(k)-24.7(h N)-15(a)-26(t)-53.2(i)-15.1(o)-17.4(n)-16.1(a)-19.5(l M)-20.7(e)-28.8(d)-23.8(i)-13.3(c)-29.2(a)-19.5(l R)-15(e)-30.6(s)-30.6(e)-21(a)-18.3(r)-19.7(c)-18.3(h C)-27(e)-19.6(n)-25.1(t)-32.4(e)-20.2(r o)-20.2(f)]TJ /Span<>> BDC ( )Tj EMC [(C)-24.2(o)-23.5(l)-28.8(o)-16.5(p)-21.8(r)-23.8(o)-24.7(c)-48.6(t)-29.7(o)-23.5(l)-28.8(o)-26.5(g)-41(y)-14.3(, H)-16.3(o)-17.4(n)-19.9(o)-20(r)-38.3(a)-18.3(r)-67.2(y )]TJ 0.023 Tw T* [(m)-24.5(e)-19.6(m)-16.6(b)-32.4(e)-20.2(r)]TJ /Span<>> BDC ( )Tj EMC [(o)-20.2(f E)-38.4(S)-28.9(C)-18.9(P)68.7(, P)-26.5(r)-26.9(e)-30.6(s)-33.7(i)-17(d)-23.3(e)-19.6(n)-25.1(t o)-20.2(f t)-33.8(h)-23(e R)-14.8(u)-29.7(s)-30.2(s)-33.7(i)-13.4(a)-15.9(n A)-43.7(s)-30.2(s)-26.9(o)-24.7(c)-45.5(i)-13.4(a)-26(t)-53.2(i)-15.1(o)-17.4(n o)-20.2(f C)-24.2(o)-23.6(l)-28.7(o)-16.5(p)-21.8(r)-23.8(o)-24.7(c)-48.6(t)-29.7(o)-23.5(l)-28.8(o)-26.5(g)-41(y)]TJ /T1_2 1 Tf 0.035 Tc -0.035 Tw 0 -1.72 TD [(S)16.4(P)13.2(I)18.2(N)7.4(-\220)5.2(\002)3.3(\240:)]TJ /T1_3 1 Tf -0.002 Tc 0.857 Tw /Span<>> BDC 4.481 0 Td ( )Tj EMC 1.368 0 Td [(79)-21.8(8)-16(9)-33.3(-)-34.9(8)-21.3(2)-12.7(2)-15.4(8)]TJ /Span<>> BDC 4.491 0 Td [( )-4626.3( )]TJ EMC /T1_2 1 Tf 0.022 Tc 0.001 Tw 12.516 0 Td [(A)2.3(u)-1.9(t)-8.2(hor)22( I)5.2(D)-1.6(:)]TJ /T1_3 1 Tf 0.004 Tc 0.019 Tw 4.564 0 Td [( 4)-38.4(8)-27.1(0)-8.2(2)-5.9(59)]TJ /T1_2 1 Tf 0.017 Tc -0.017 Tw -27.421 -1.27 Td [(OR)1.6(C)-27.8(ID)-6.6(:)]TJ /T1_3 1 Tf 0.031 Tc -0.008 Tw /Span<>> BDC 3.027 0 Td ( )Tj EMC 2.823 0 Td [(0000)-9.9(-)-9.4(000)18.8(2)34.2(-)-1.9(8)-11.4(4)-11.4(80)-9.9(-)18.5(9)25.2(3)19(6)24.3(2)]TJ /Span<>> BDC 9.529 0 Td ( )Tj EMC 1.765 0 Td ( )Tj /Span<>> BDC ( )Tj EMC /T1_2 1 Tf 0.007 Tc -0.007 Tw 5.714 0 Td [(S)-23.4(C)-3.4(O)-10.1(PU)-14.9(S)-17.9(:)]TJ /T1_3 1 Tf -0.006 Tc 0.029 Tw 3.662 0 Td [( I)-15.9(D)-6( 57)-4.6(2)-14.5(1)-22.2(37)13.7(6)-30.3(0)-18.2(2)-19.4(8)-33(6)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.007 Tc -0.007 Tw 7 0 0 7 274.9606 406.7008 Tm [(CO)-33.2(-)-16.9(E)-3(D)-3.6(I)-47.1(T)-19.1(O)-6.6(R)-38(S)]TJ 0 0 0 1 k /GS1 gs 0 Tc 0.083 Tw 6.3 0 0 6.3 274.9606 395.8661 Tm [(S)-33.7(e)-23.3(r)-25.3(g)-29.1(e)-27.5(i I)-36.2(.)]TJ /Span<>> BDC ( )Tj EMC [(A)-20.1(c)-19.8(h)-19.2(k)-38.4(a)-29.7(s)-26.1(o)-18.9(v \()-4.5(M)-20.9(o)-20(s)-27.5(c)-14.4(o)-18(w)4.3(, R)-18.7(u)-23(s)-25.2(s)-35.7(i)-20.9(a)19.7(\))]TJ /T1_3 1 Tf /Span<>> BDC ( )Tj EMC [(\227 D)-22.4(r)21.2(. o)-20.2(f S)-30.9(c)-45.5(i)-8.7(. \()2.8(M)-20.7(e)-28.8(d)-19.9(.)33.4(\))-22.6(, P)-26.4(r)-23.8(o)-20.2(f)-36.1(e)-30.6(s)-30.2(s)-26.9(o)-20(r)-4.1(, c)-14.8(o)-20(r)-47.7(r)-27(e)-30.6(s)-17.5(p)-30.1(o)-17.4(n)-22.5(d)]TJ 0 Tw 6.3 0 0 6.3 493.8455 395.8661 Tm (-)Tj 0.278 Tw 6.3 0 0 6.3 274.9606 387.8661 Tm [(i)-11.6(n)-19.9(g m)-24.4(e)-19.6(m)-16.6(b)-32.4(e)-20.2(r o)-20.2(f )0.5(R)-51(A)-47.8(S)-38.7(, d)-23.8(i)-14.3(r)-27(e)-26.9(c)-48.6(t)-29.7(o)-20(r o)-20.2(f)]TJ /Span<>> BDC ( )Tj EMC 14.589 0 Td [(t)-33.8(h)-23.1(e R)-37.8(y)-41.4(z)-20.6(h)-22(i)-14.8(k)-24.7(h N)-15(a)-26(t)-53.1(i)-15.1(o)-17.4(n)-16.1(a)-19.5(l M)-20.7(e)-28.8(d)-23.8(i)-13.3(c)-29.1(a)-19.6(l R)-15(e)-30.6(s)-30.6(e)-21(a)-18.3(r)-19.7(c)-18.3(h C)-27(e)-19.6(n)-25.1(t)-32.4(e)-20.2(r )]TJ 0.023 Tw -14.589 -1.27 Td [(o)-20.2(f)]TJ /Span<>> BDC ( )Tj EMC [(C)-24.3(o)-23.5(l)-28.8(o)-16.5(p)-21.8(r)-23.7(o)-24.7(c)-48.6(t)-29.7(o)-23.5(l)-28.8(o)-26.5(g)-41(y)-14.3(, m)-24.5(e)-19.6(m)-16.6(b)-32.4(e)-20.2(r o)-20.2(f E)-38.4(S)-28.9(C)-18.9(P)96(.)]TJ /T1_2 1 Tf 0.035 Tc -0.035 Tw T* [(S)16.4(P)13.2(I)18.2(N)7.4(-\220)5.2(\002)3.3(\240:)]TJ /T1_3 1 Tf 0.007 Tc 0.964 Tw /Span<>> BDC 4.481 0 Td ( )Tj EMC 1.368 0 Td [(5)-24.1(4)-24.1(67)33.6(-)51.9(1)12(0)-16.8(62)]TJ /Span<>> BDC 4.375 0 Td [( )-4510.3( )]TJ EMC /T1_2 1 Tf 0.022 Tc 0.001 Tw 12.633 0 Td [(A)2.3(u)-1.9(t)-8.1(hor)22( I)5.2(D)-1.6(:)]TJ /T1_3 1 Tf -0.029 Tc 0.947 Tw /Span<>> BDC 4.564 0 Td ( )Tj EMC [(2)-33.4(6)-39.8(51)-25.3(4)-51.1(2)]TJ /T1_2 1 Tf 0.017 Tc -0.017 Tw -27.421 -1.27 Td [(OR)1.6(C)-27.8(ID)-6.6(:)]TJ /T1_3 1 Tf 0.031 Tc 1.568 Tw /Span<>> BDC 3.027 0 Td ( )Tj EMC 2.823 0 Td [(0000)-9.9(-)-9.4(000)21.1(1)48.7(-)18.5(9)19.8(2)16.7(9)5.7(4)-5.1(-)14.8(54)-14.5(4)46.9(7)]TJ /Span<>> BDC 9.461 0 Td ( )Tj EMC /T1_2 1 Tf 0.007 Tc -0.007 Tw 7.546 0 Td [(S)-23.4(C)-3.4(O)-10.1(PU)-14.9(S)-17.9(:)]TJ /T1_3 1 Tf -0.007 Tc 0.03 Tw /Span<>> BDC 3.662 0 Td ( )Tj EMC 2.052 0 Td [(I)-16.9(D)-7( 6)-25.9(6)-31.3(0)-11(3)-7.8(3)-34.1(49)-23.7(6)-39.9(4)-4.2(5)]TJ /T1_2 1 Tf 0 Tc 0.105 Tw -28.571 -9.414 Td [(Y)-29.2(v)-18.9(e)-23.6(s P)-10.1(a)-21.6(n)-25.7(i)-21.4(s \()-8.1(P)-10.1(a)-23.7(r)-59.2(i)-21.4(s)-29.7(, F)-11.9(r)-35.7(a)-21.6(n)-25.1(c)-14.7(e)21.5(\))]TJ /T1_3 1 Tf /Span<>> BDC ( )Tj EMC [(\227 M)-6.8(D)-15(, P)-14.7(h)-9.2(D)-15(, U)-13.2(n)-21.9(i)-22.4(v)-26.5(e)-20.2(r)-37.8(s)-33.7(i)-23.8(t)-32.4(\351 P)-18.4(a)-18.3(r)-63.1(i)-15.6(s V)-43.8(I)-34.3(I)-44.3(, P)-26.5(r)-23.8(o)-20.2(f)-36.1(e)-30.6(s)-30.2(s)-26.9(o)-20(r o)-20.2(f S)-20.2(u)-15.9(r)-24.7(g)-22.4(e)-20.2(r)-67.2(y)-14.3(, )]TJ 0.02 Tc 0.003 Tw 0 -1.27 TD [(He)-1(a)-1.1(d)20( of)20( t)-13.8(h)-3.1(e)20( D)-9.7(e)1.2(p)-7.9(a)1.7(r)-46.3(t)-13.8(m)-4.5(e)0.5(n)-5.1(t)20( of)20( C)-4.3(o)-3.5(l)-8.8(or)-7(e)-7(c)-28.6(t)-24.1(a)0.5(l)20( Su)4.1(r)-4.6(g)-2.4(er)-47.2(y)5.7(,)20( B)-7(e)-0.9(a)2.8(u)-1.6(j)4.9(o)2.6(n)20( H)3.7(o)-3.7(s)2.6(p)-6.5(i)-3.8(t)-24.2(a)0.5(l)-19.2(.)]TJ /T1_2 1 Tf 0.017 Tc -0.017 Tw 0 -1.72 TD [(OR)1.6(C)-27.8(ID)-6.6(:)]TJ /T1_3 1 Tf 0.031 Tc 0.736 Tw /Span<>> BDC 3.027 0 Td ( )Tj EMC 2.823 0 Td [(0000)-9.9(-)-9.4(000)21.1(1)48.7(-)18.5(9)18.9(5)22.9(5)31.1(3)9.6(-)18.5(9)29.8(7)32.5(2)27.4(7)]TJ /Span<>> BDC 9.355 0 Td [( )-938.6( )]TJ EMC /T1_2 1 Tf 0.007 Tc -0.007 Tw [(S)-23.3(C)-3.4(O)-10.1(PU)-14.8(S)-18(:)]TJ /T1_3 1 Tf 0.004 Tc 0.763 Tw /Span<>> BDC 10.601 0 Td ( )Tj EMC [(I)-5.9(D)4( )743.7(3)8.6(527)5.9(5)-23.5(8)-23(6)-20.3(0)-31.7(4)-31.7(0)-27.1(0)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.01 Tc 0.013 Tw 7 0 0 7 274.9606 262.7008 Tm [(E)-40.4(X)-19.4(EC)-9.8(U)-23.5(T)-51(I)-33.6(V)-8.4(E)10( S)-5.2(EC)-6.5(R)-6.5(E)-44.1(T)21(A)-7.9(R)-8.8(Y)]TJ 0 0 0 1 k /GS1 gs 0 Tc 0.262 Tw 6.3 0 0 6.3 274.9606 251.8661 Tm [(E)-16(v)-22.1(g)-29.1(e)-23.1(n)-19.8(y )0.6(G)-28.4(.)]TJ /Span<>> BDC ( )Tj EMC 4.986 0 Td [(R)-33.6(y)-21.6(b)-24.4(a)-22.7(k)-18.9(o)-18.9(v )0.5(\()-4.5(M)-21(o)-20(s)-27.5(c)-14.4(o)-18(w)4.3(, )0.6(R)-18.7(u)-23(s)-25.2(s)-35.7(i)-21(a)19.7(\))]TJ /T1_3 1 Tf /Span<>> BDC ( )Tj EMC 12.57 0 Td [(\227 )0.5(D)-22.4(r)21.2(. )0.6(o)-20.2(f )0.5(S)-31(c)-45.5(i)-8.7(. )0.5(\()2.8(M)-20.6(e)-28.8(d)-19.9(.)33.4(\))-22.6(, )0.5(p)-21.8(r)-23.8(o)-20.2(f)-36.1(e)-30.6(s)-30.1(s)-26.9(o)-20(r )0.5(o)-20.2(f )0.5(R)-51(A)-47.8(S)-38.7(, )]TJ 0.273 Tw -17.557 -1.27 Td [(H)-20.4(e)-21(a)-21.1(d)]TJ /Span<>> BDC ( )Tj EMC [(o)-20.2(f)]TJ /Span<>> BDC ( )Tj EMC [(o)-17.4(n)-18.1(c)-14.8(o)-16.5(p)-21.8(r)-23.7(o)-24.7(c)-48.6(t)-29.7(o)-23.5(l)-28.8(o)-26.5(g)-41(y d)-23.3(e)-18.8(p)-27.9(a)-18.2(r)-66.3(t)-33.8(m)-24.5(e)-19.6(n)-25.1(t a)-26(t t)-33.8(h)-23.1(e R)-37.9(y)-41.4(z)-20.6(h)-22(i)-14.8(k)-24.7(h N)-15(a)-26(t)-53.2(i)-15.1(o)-17.4(n)-16.1(a)-19.5(l M)-20.7(e)-28.8(d)-23.8(i)-13.3(c)-29.2(a)-19.5(l R)-15(e)-30.6(s)-30.6(e)-21(a)-18.3(r)-19.7(c)-18.3(h )]TJ 0.024 Tc -0.001 Tw 0 -1.27 TD [(C)-3(e)4.4(n)-1.1(t)-8.4(e)3.8(r)24.1( o)3.8(f)]TJ /Span<>> BDC 3.803 0 Td ( )Tj EMC [(Co)0.5(l)-4.8(o)7.5(p)2.3(ro)-0.7(c)-24.6(t)-5.7(o)0.5(l)-4.8(o)-2.5(g)-17(y)]TJ /T1_2 1 Tf 0.035 Tc -0.035 Tw -3.803 -1.72 Td [(S)16.4(P)13.2(I)18.2(N)7.4(-\220)5.2(\002)3.3(\240:)]TJ /T1_3 1 Tf -0.023 Tc 0.947 Tw /Span<>> BDC 4.481 0 Td ( )Tj EMC 1.368 0 Td [(9)-35.1(5)-26.6(9)-41.9(9)-54.3(-3)-23.8(3)-25.5(9)-47.7(0)]TJ /Span<>> BDC 4.423 0 Td [( )0.5( )-4557.3( )]TJ EMC /T1_2 1 Tf 0.022 Tc 0.001 Tw 12.585 0 Td [(A)2.3(u)-1.9(t)-8.2(hor)22( I)5.2(D)-1.6(:)]TJ /T1_3 1 Tf 0.024 Tc 0.894 Tw /Span<>> BDC 4.564 0 Td ( )Tj EMC [(6)17.3(7)43.6(606)20.5(3)]TJ /T1_2 1 Tf 0.007 Tc -0.007 Tw -27.421 -1.27 Td [(S)-23.4(C)-3.4(O)-10.1(PU)-14.9(S)-17.9(:)]TJ /T1_3 1 Tf 0 Tc 0.023 Tw /Span<>> BDC 3.662 0 Td ( )Tj EMC 2.187 0 Td [(I)-9.9(D 6)-18.9(6)-24.3(0)-12.2(2)-10.7(24)15.9(7)3.7(1)-7.6(5)6.4(7)]TJ /T1_2 1 Tf 0.04 Tc 0.411 Tw 6.5 0 0 6.5 42.5197 156.8624 Tm [(\207)14.1(\210)-7.6(\006)1.6(\b\004)-12.6(\f)28.1( )6.1(\220)-28.1(\f)3.4(\211)1.5(\201)-1.6(\r\b)28.2( )28.2( \212)-1(\r)3.7(\006)-0.9(\r)1(\201)-1.5(\r\b)3.2(\001)28.2( \006)-0.8(\r)1.8(\204)-3.2(\r\b)5.1(\213)0.7(\t)3.8(\006)4.6(\210)6.1(\r\214)1.5(\013)-6.2(\216)40( )]TJ 0.041 Tc 0.461 Tw 0 -1.276 TD [(\b\004)3.8(\210)-11.3(\201)1.2(\b)2.8(\013)2.4(\005)27.7( )0.5(\t)4.6(\213)-12.5(\240)-14.4(\004)0.9(\b)2.9(\t)2.8(\005)3.7(,)27.7( )0.6(\006)-1.3(\r\220)-1.2(\002)0.9(\214\r\b)-2.1(\240)-23.5(\210)5.6(\r\214)1.1(\013)-6.6(\216)27.7( )0.5(\026)11.1(\032)7.4(\021)-12.4(,)27.8( )0.5(\240)-24.4(\f)-3.5(\235)41( )]TJ 0.025 Tc 0.064 Tw T* [(\212)-7.1(\210)-10.8(\206)-4.4(\f\t\220)-19.4(\004)-1.8(\204)-6.7(\t\t)25( \002)-5.3(\217\b)-2.4(\002)-3.4()4(\b\013)-9.3(\216)25( \b)-2.7(\004)1(\210)-14(\201)-1.5(\b\013)-9.4(\216)25( \006)-4(\r)-4.4(\213)-4.9(\210)13.9(\f\001)28.3(\003)-13.5(\004)-8(\003)-6.2(\002)-3.3()25( \240)-5.6(\t)-3(\217)]TJ 0 Tc 0 Tw 22.307 0 Td (-)Tj 0.074 Tw -22.307 -1.276 Td [(\217)-17.1(\r)-24.4(\006)-34.8(\003)-38.5(\004)-26.8(\204)-31.7(\t)-24.9(\005 \b)-27.7(\004 \217)-16.7(\002)-25.9(\t)-27.9(\217)-24.8(\220)-44.4(\004)-26.8(\b)-24.9(\t)-27.9(\r \210)-38.9(\201)-29.7(\r)-27.8(\b)-27.4(\002)-26(\005 \217)-52.1(\003)-29.4(\r)-29.6(\212)-29.2(\r)-27.8(\b)-24.9(\t \220)-44.4(\004)-26.8(\b)-29.9(\240)-30.7(\t)-29.9(\240)-42(\004)]TJ 0 Tw 22.307 0 Td (-)Tj 0.26 Tw -22.307 -1.276 Td [(\003)-38.5(\004 )0.5(\b)-27.7(\004)-24(\210)-29.7(\220)-39.2(, )0.5(\b)-27.7(\004 )0.6(\217)-16.7(\002)-26(\t)-27.9(\217)-24.8(\220)-44.4(\004)-26.8(\b)-24.9(\t)-27.9(\r )0.5(\210)-39(\201)-29.6(\r)-27.8(\b)-27.4(\002)-26(\005 )0.5(\217)-52.1(\003)-29.4(\r)-29.6(\212)-29.2(\r)-27.8(\b)-24.9(\t )0.6(\240)-28(\002)-24.5(\220)-51.2(\003)-31.2(\002)-21.1(\006)-29.4(\004 )]TJ 0.088 Tw T* [(\b)-27.7(\004)-24(\210)-29.8(\220 \212)-28.7(\002 \b)-27.7(\004)-24(\210)-39(\201)-26.4(\b)-24.9(\013)-27.6(\214 \217)-24.9(\212)-29.2(\r)-26.3(\204)-31.7(\t)-27.7(\004)-40.8(\f)-24.9(\001)-18.4(\b)-27.4(\002)-30.3(\217)-52.1(\003)-35.8(\235)-27.1(\214 \()23.2(\212)-28.7(\002 \217)-16.7(\002)-30.3(\217)-52.1(\003)-31.2(\002)-29(\235)-25.1(\b)-24.9(\t)-24.7(\211 )]TJ -0.016 Tc 0.039 Tw 0 -1.276 TD [(\b)-43.7(\004)-16( 0)-12.7(7)44.3(.)0.5(1)-8.2(2)-35.2(.)-33.9(2)-28.1(0)-22.2(2)-15.4(2\))]TJ 0.019 Tc 0.004 Tw 0 -1.712 TD [(\217)19( 2)10.1(8)-5.4(.)35.5(1)26.8(2.)1.1(2)6.9(0)16.4(1)15(8:)]TJ /T1_3 1 Tf 0 Tc 0.169 Tw 0 -1.276 TD [(1)4.8(4)-8.4(.0)-8.8(1)-3.4(.)23.9(1)-15.2(3)]TJ /Span<>> BDC ( )Tj EMC [(\227 \214)-23.4(\031)-38.3(\004)-24.9(\036)-23.6(\r)-25.6(\026)-37(\016 \007)-22.8(\017)-17.8(\026)-19(\020)-25.6(\027)-21.3(\024)-24.7(\f)-51(\021)-33.8(\017)-15.7(\022)-23.3(\017)-35.1(, \035)-28.4(\031)-38.4(\004)-24.9(\036)-23.6(\r)-25.6(\026)-37(\016 \021)-26.6(\036)-18.8(\030)-27.9(\026)-19(\023)-15.2(\017)-22.3(\016 )]TJ 0.023 Tc 0 Tw T* [(\()57.8(\n)1.5(\036)-12.2(\007\017)7.3(\006\017)7.3(\027)3.5(\f)4.2(\022\017)-2.4(\036)23( \027)5.2(\026\031)-4.9(\022\017)55.5(\))]TJ 23.549 11.923 Td [(1)27.8(4)14.6(.)22.8(0)14.2(1)19.6(.)46.9(1)15.5(2)]TJ /Span<>> BDC 3.592 0 Td ( )Tj EMC [(\227)23( \210\027)7.3(\022)5(\024)-4.5(\035)3.5(\024)1.7(\020)-2.6(\017)0.6(\016)23( \()57.8(\n)1.5(\036)-12.2(\007\017)7.3(\006\017)7.3(\027)3.6(\f)4.2(\022\017)-2.4(\036)23( \027)5.2(\026\031)-4.9(\022\017)55.5(\))]TJ 0 Tc 0.023 Tw -3.592 -1.228 Td [(1)4.8(4)-8.4(.0)-8.8(1)-3.4(.)23.9(1)16.2(7)]TJ /Span<>> BDC ( )Tj EMC [(\227 \216)-30.1(\017)-15.8(\030)-27.5(\031)-38.4(\030)-24.3(\020)-25.6(\017)-22.4(\016 \()34.8(\n)-21.5(\036)-35.2(\007)-22.9(\017)-15.7(\006)-22.9(\017)-15.6(\027)-19.5(\f)-18.8(\022)-23.3(\017)-25.4(\036 \027)-17.8(\026)-22.9(\031)-27.9(\022)-23.3(\017)32.5(\))]TJ 0 -1.228 TD [(1)4.8(4)-8.4(.0)-8.8(1)-3.4(.)23.9(1)3.9(9)]TJ /Span<>> BDC ( )Tj EMC [(\227 \212)-22(\036)-33.2(\021)-19.2(\f)-18.8(\022)-35.1(\026)-37(\016 \b)-24.7(\017)-15.8(\030)-27.5(\031)-38.4(\030)-24.3(\020)-25.6(\017)-22.3(\016 \()34.8(\n)-21.5(\036)-35.2(\007)-22.9(\017)-15.7(\006)-22.9(\017)-15.7(\027)-19.5(\f)-18.8(\022)-23.3(\017)-25.3(\036 \027)-17.8(\026)-22.9(\031)-27.9(\022)-23.3(\017)32.5(\))]TJ 0.049 Tw T* [(1)4.8(4)-8.4(.0)-2.9(3)-0.8(.0)-11.1(2)]TJ /Span<>> BDC ( )Tj EMC [(\227 \215)-12.3(\026)-28.4(\021)-23.4(\024)-27.5(\035)-19.5(\024)-21.3(\020)-25.6(\017)-12.9(\004)-24.8(\036)-27(\f)-18.8(\022)-35.1(\026)-37(\016 \026)-17.5(\027)-17.8(\026)-28.4(\021)-23.4(\024)-17.4(\n)-14.7(\017)-22.4(\016 \()34.8(\n)-21.5(\036)-35.2(\007)-22.9(\017)-15.6(\006)-22.9(\017)-15.7(\027)-19.5(\f)-18.8(\022)-23.3(\017)-25.4(\036 )]TJ 0.023 Tc -0.023 Tw T* [(\027)5.2(\026\031)-4.9(\022\017)55.5(\))]TJ /T1_2 1 Tf -0.016 Tc 0.039 Tw 0 -1.664 TD [(\217)-16( 1)-13.2(5)-25.6(.)0.5(1)-7.3(0)-31.1(.)-33.9(2)-28.1(0)-18.6(1)-4.5(9)-28.6(:)]TJ /T1_3 1 Tf 0 Tc 0.018 Tw 0 -1.228 TD [(1)4.8(4)-8.4(.0)-8.8(1)-3.4(.)-16.8(2)-12.5(8)]TJ /Span<>> BDC ( )Tj EMC [(\227 \206)66(\026)-17.2(\f)-51(\021)-44.3(\030)-28.4(\024)-10.7(\220)-21.3(\027)-29.7(\021)-26.6(\036)-18.8(\030)-28.4(\024)-27.5(\035)-19.5(\024)-21.3(\020)-25.6(\017)-22.3(\016 \()34.8(\n)-21.5(\036)-35.2(\007)-22.9(\017)-15.7(\006)-22.9(\017)-15.7(\027)-19.5(\f)-18.8(\022)-23.3(\017)-25.4(\036 \027)-17.8(\026)-22.9(\031)-27.9(\022)-23.3(\017)32.6(\))]TJ /T1_2 1 Tf 0.006 Tc 0.017 Tw 0 -1.664 TD [(\217)6( 0)3.4(1)-3.9(.)-8.2(02)-13.2(.)-11.9(2)-6.1(02)6.6(2)-2.1(:)]TJ /T1_3 1 Tf 0 Tc 0.156 Tw 0 -1.228 TD [(3)-0.8(.)23.9(1)-3.4(.)-2.5(6)]TJ /Span<>> BDC ( )Tj EMC [(\227 \210)-23.2(\027)-15.6(\022)-18(\024)-27.5(\035)-19.5(\024)-21.3(\020)-25.6(\017)-22.4(\016)-34.6(, \035)-28.4(\031)-38.3(\004)-24.9(\036)-23.6(\r)-25.6(\026)-37(\016 \021)-26.6(\036)-18.8(\030)-27.9(\026)-19(\023)-15.2(\017)-22.4(\016 )0.5(\()34.8(\n)-21.5(\036)-35.2(\007)-22.9(\017)-15.7(\006)-22.9(\017)-15.7(\027)-19.5(\f)-18.8(\022)-23.3(\017)-25.3(\036 )]TJ 0.023 Tc -0.023 Tw T* [(\027)5.2(\026\031)-4.9(\022\017)55.5(\))]TJ 0 Tw 23.549 11.922 Td [(3)22.2(.)46.9(1)19.6(.)30.1(9)]TJ /Span<>> BDC 2.065 0 Td ( )Tj EMC [(\227)23( \216)-7.2(\017)7.2(\030)-4.5(\031)-15.4(\030)-1.3(\020)-2.6(\017)0.6(\016)23( \()57.7(\n)1.5(\036)-12.2(\007\017)7.4(\006\017)7.3(\027)3.5(\f)4.2(\022\017)-2.4(\036)23( \027)5.2(\026\031)-4.9(\022\017)55.5(\))]TJ 0 Tc 0.023 Tw -2.065 -1.276 Td [(3)-0.8(.)23.9(1)-3.4(.)23.9(1)21.6(1)]TJ /Span<>> BDC ( )Tj EMC [(\227 \212)-21.9(\036)-33.3(\021)-19.2(\f)-18.8(\022)-35.1(\026)-37(\016 \b)-24.7(\017)-15.8(\030)-27.5(\031)-38.4(\030)-24.3(\020)-25.5(\017)-22.4(\016 \()34.8(\n)-21.5(\036)-35.2(\007)-22.9(\017)-15.7(\006)-22.9(\017)-15.7(\027)-19.5(\f)-18.8(\022)-23.3(\017)-25.3(\036 \027)-17.8(\026)-22.9(\031)-27.9(\022)-23.3(\017)32.5(\))]TJ 0.03 Tc 0.326 Tw 0 -1.276 TD [(3)22.5(.)10.5(3)22.5(.)6.5(2)]TJ /Span<>> BDC 2.157 0 Td ( )Tj EMC [(\227)23.3( \215)11(\026)-5.1(\021\024)-4.2(\035)3.8(\024)2.1(\020)-2.3(\017)10.4(\004)-1.5(\036)-3.7(\f)4.5(\022)-11.7(\026)-13.7(\016)23.3( \026)5.8(\027)5.6(\026)-5.1(\021\024)6(\n)8.6(\017)0.9(\016)23.4( \()58.1(\n)1.8(\036)-11.8(\007\017)7.6(\006)0.5(\017)7.6(\027)3.8(\f)4.6(\022\017)-2.1(\036)30( )]TJ 0.023 Tc -0.023 Tw -2.157 -1.276 Td [(\027)5.2(\026\031)-4.9(\022\017)55.5(\))]TJ /T1_2 1 Tf 0 Tw 0 -1.712 TD [(\217)23( 1)29.9(4.)8.8(0)-3.2(4.)5.1(2)10.9(0)16.8(2)23.6(2)14.9(:)]TJ /T1_3 1 Tf 0 Tc 0.023 Tw 0 -1.276 TD [(1)-3.4(.)-3.4(5)-0.8(.)14.4(7)]TJ /Span<>> BDC ( )Tj EMC [(\227 \206)59.3(\036)-22.2(\027)-23.9(\036)-33.3(\021)-33.8(\017)-15.7(\022)-35.1(\026 \()25.4(\002)-19.9(\017)-21.3(\024)-27.5(\035)-19.5(\024)-21.3(\020)-25.6(\017)-12.9(\004)-24.8(\036)-27(\f)-18.8(\022)-23.3(\017)-25.4(\036 \027)-17.8(\026)-22.9(\031)-27.9(\022)-23.3(\017)32.6(\))]TJ 0.023 Tc 0 Tw 0 -1.276 TD [(1)19.6(.)19.6(5)22.2(.)37.4(7)]TJ /Span<>> BDC 2.085 0 Td ( )Tj EMC [(\227)23( \206)82.3(\036)0.8(\027)-1(\036)-10.3(\021)-10.8(\017)7.3(\022)-12.1(\026)23( \()57.8(\n)1.5(\036)-12.2(\007\017)7.3(\006\017)7.3(\027)3.6(\f)4.2(\022\017)-2.4(\036)23( \027)5.2(\026\031)-4.9(\022\017)55.5(\))]TJ -2.085 -1.276 Td [(3)22.2(.)46.9(1)19.6(.)6.2(2)14.1(5)]TJ /Span<>> BDC 2.598 0 Td ( )Tj EMC [(\227)23( \214\031)-15.4(\004)-1.9(\036)-0.6(\r)-2.6(\026)-14(\016)23( \007\017)5.3(\026)4(\020)-2.7(\027)1.8(\024)-1.7(\f)-28(\021)-10.8(\017)7.3(\022)-12.1(\026)23( \()57.8(\n)1.5(\036)-12.2(\007\017)7.3(\006\017)7.3(\027)3.5(\f)4.2(\022\017)-2.4(\036)23( \027)5.2(\026\031)-4.9(\022\017)55.5(\))]TJ 0 Tc 0.29 Tw -2.598 -1.276 Td [(3)-0.8(.)23.9(1)-3.4(.)-12.9(3)-15.6(0)]TJ /Span<>> BDC ( )Tj EMC [(\227 \206)66(\026)-17.2(\f)-51(\021)-44.3(\030)-28.4(\024)-10.7(\220)-21.3(\027)-29.7(\021)-26.6(\036)-18.7(\030)-28.4(\024)-27.5(\035)-19.5(\024)-21.3(\020)-25.6(\017)-22.4(\016 \017 \007)-22.9(\017)-25.4(\036)-33.3(\021)-23.4(\024)-27.5(\035)-19.5(\024)-21.3(\020)-25.6(\017)-22.4(\016 \()34.8(\n)-21.5(\036)-35.2(\007)-22.9(\017)]TJ 0 Tw 22.325 0 Td (-)Tj 0.023 Tc -22.325 -1.276 Td [(\006\017)7.3(\027)3.5(\f)4.2(\022\017)-2.4(\036)23( \027)5.2(\026\031)-4.9(\022\017)55.5(\))]TJ ET 0.25 0.17 0 0.03 K 1 w 4 M /GS0 gs q 1 0 0 1 42.5197 170.0786 cm 0 0 m 453.543 0 l S Q endstream endobj 2738 0 obj <>>>/Subtype/Form>>stream 1 0.68 0 0.12 k /GS0 gs 42.52 54.638 453.543 1.375 re f 42.52 52.257 453.543 1.375 re f endstream endobj 2736 0 obj <>stream BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 0.023 Tw 14 0 0 14 121.2344 747.495 Tm [(EDIT)35(ORIAL BO)21(ARD)]TJ 0.01 Tc 0.018 Tw [( OF)5( "K)52(OL)34(OPROKT)35(OL)34(OGIA")5( JOURNAL)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0 Tc 0 Tw 8.5 0 0 8.5 36 729.991 Tm [(EDIT)28(OR-IN-CHIEF)]TJ 0 -1.059 TD [(Y)89(uri \037)-21(. Sh)11(ely)10(gin,)]TJ /T1_0 1 Tf [( Dr)48(. of Sci. \(Med.\), Pr)24(of., academician of RA)11(S, Ryzhikh National Medical R)20(esear)24(ch Center of Colopr)24(octology \(Moscow)17(, R)21(ussia\))]TJ /T1_1 1 Tf 0 -2.059 TD [(CO-EDIT)28(ORS)]TJ 0 -1.059 TD [(Ser)11(gei I. Achkaso)21(v)-18(,)]TJ /T1_0 1 Tf [( Dr)48(. of Sci. \(Med.\), Pr)24(of., corr)24.1(esponding member of RA)11(S, Ryzhikh National Medical R)20(esear)24(ch Center of Colopr)24.1(octology )]TJ 0 -1.059 TD [(\(Moscow)17.1(, R)21(ussia\))]TJ /T1_1 1 Tf 0 -1.153 TD [(Y)63(v)10(es P)10(anis,)]TJ /T1_0 1 Tf [( MD, Pr)24(of., Univer)11(sit\351 P)20(aris VII \(P)20(aris, F)21(r)21(ance\))]TJ /T1_1 1 Tf 0 -2.059 TD [(EXECUTIVE SECRE)-20.9(T)39(AR)31(Y)]TJ 0 -1.153 TD [(E)21(vgen)20(y G. R)21(ybak)21(o)21(v)-18(,)]TJ /T1_0 1 Tf [( Dr)48.1(. of Sci. \(Med.\), Pr)23.9(of. of RA)11(S, Ryzhikh National Medical R)20(esear)24(ch Center of\016Colopr)24(octology \(Moscow)17(, R)21(ussia\))]TJ /T1_1 1 Tf 8 0 0 8 36 624.21 Tm [(Elena A)-31.9(.\026Belouso)21(v)10(a,)]TJ /T1_0 1 Tf [( Dr)48.1(. of Sci. \(Med.\), Pr)24.2(of., )]TJ 0 -1.25 TD [(Moscow R)20.1(egional R)20.1(esear)24(ch and Clinical Institute )]TJ T* [(\(Moscow)17.1(, R)21(ussia\))]TJ /T1_1 1 Tf T* [(Leonid A)-31.9(.\026Blagodarn)20(y)13(,)]TJ /T1_0 1 Tf [( Dr)48.1(. of Sci. \(Med.\), )]TJ T* [(Pr)24(of., R)21.1(ussian Medical Academy of P)7.2(ostgr)21.1(aduate )]TJ T* [(Education \(Moscow)17.2(, R)21(ussia\))]TJ /T1_1 1 Tf T* [(Oleg V)39(.\026Golo)21.1(v)10(enk)21(o,)]TJ /T1_0 1 Tf [( Dr)48(. of Sci. \(Med.\), Pr)24.2(of., )]TJ T* [(R)21(ussian Medical Academy of P)7.3(ostgr)21(aduate )]TJ T* [(Education \(Moscow)17.2(, R)21(ussia\))]TJ /T1_1 1 Tf T* [(E)21(ugen)20(y G.\026Grigor)-29.9(y)11(e)10(v)-18(,)]TJ /T1_0 1 Tf [( Dr)48.1(. of Sci. \(Med.\), Pr)24.2(of., )]TJ T* [(corr)24(esponding member of RA)11.3(S, Irkutsk State )]TJ T* [(Medical Univer)11.1(sit)-29.9(y \(Irkutsk, R)21.1(ussia\))]TJ /T1_1 1 Tf T* [(Vitalii S.\026Gr)10.1(o)21(shilin,)]TJ /T1_0 1 Tf [( Dr)48(. of Sci. \(Med.\), Pr)24.2(of., )]TJ T* [(R)10(ostov State Medical Univer)11.3(sit)-30(y \(R)10(ostov)-20.9(-on-Don, )]TJ T* [(R)21(ussia\))]TJ /T1_1 1 Tf T* [(E)21(vgen)20(y N)-20(.\026Imy)21.1(anito)21(v)-18(,)]TJ /T1_0 1 Tf [( Dr)48.1(. of Sci., Pr)24.1(of., )]TJ T* [(corr)24(esponding member of RA)11.3(S \(Saint-Peter)11.1(sbur)24(g, )]TJ T* [(R)21(ussia\))]TJ /T1_1 1 Tf T* [(Alek)21(se)10(y M.\026K)32.1(ar)10(ach)11(un,)]TJ /T1_0 1 Tf [( Dr)48(. of Sci. \(Med.\), Pr)24.2(of., )]TJ T* [(Petr)24(ov National Medical R)20.2(esear)24.1(ch Center of )]TJ T* [(Oncology \(Saint-Peter)11.2(sbur)24(g, R)21.1(ussia\))]TJ /T1_1 1 Tf T* [(Oleg Y)89(u.\026K)32.1(arpukhin,)]TJ /T1_0 1 Tf [( Dr)48.1(. of Sci. \(Med.\), Pr)24.2(of., )]TJ T* [(K)42(a)10(z)10(an National Medical Univer)11.3(sit)-30(y \(K)42(a)10(z)10.1(an, R)21(ussia\))]TJ /T1_1 1 Tf T* [(Dmitr)-30(y A)-31.9(.\026Mor)10(o)10(z)10(o)21(v)-18(,)]TJ /T1_0 1 Tf [( Dr)48.1(. of Sci. \(Med.\), Pr)24.1(of., )]TJ T* [(Sechenov Fir)11.1(st Moscow State Medical Univer)11.3(sit)-29.9(y )]TJ T* [(\(Moscow)17.1(, R)21(ussia\))]TJ /T1_1 1 Tf 20.976 31.25 Td [(Ale)21(xander V)39.1(.\026Mur)10(avie)10(v)-18(,)]TJ /T1_0 1 Tf [( Dr)48(. of Sci. \(Med.\), Pr)24.2(of., )]TJ T* [(Stavr)24(opol State Medical Univer)11.3(sit)-30(y \(Stavr)24.1(opol, )]TJ T* [(R)21(ussia\))]TJ /T1_1 1 Tf T* [(Vitaly V)39.1(.\026Omely)21(ano)21(v)10(skiy)13(,)]TJ /T1_0 1 Tf [( Dr)48.1(. of Sci. \(Med.\), )]TJ T* [(Pr)24(of., T)72(he Center of Healthcar)24.3(e Qualit)-29.9(y Assessment )]TJ T* [(and Contr)24.1(ol of the Ministr)-30.8(y of Health of the )]TJ T* [(R)21(ussian F)42.1(eder)21(ation, R)21.1(ussian Medical Academy )]TJ T* [(of\016P)7(ostgr)21.1(aduate Education \(Moscow)17.3(, R)21(ussia\))]TJ /T1_1 1 Tf T* [(Igor V)39(.\026P)10(oddubn)20.1(y)13(,)]TJ /T1_0 1 Tf [( Dr)48(. of Sci. \(Med.\), Pr)24.2(of., )]TJ T* [(A.I.\016Y)99(evdokimov Moscow State Univer)11.3(sit)-29.9(y )]TJ T* [(of\016Medicine and Dentistr)-30.7(y \(Moscow)17.1(, R)21(ussia\))]TJ /T1_1 1 Tf T* [(V)42(adim V)39(.\026P)10(olo)21.1(vinkin,)]TJ /T1_0 1 Tf [( Dr)48(. of Sci. \(Med.\), Pr)24.2(of., )]TJ T* [(R)20(egional Clinical Hospital No\0161 named af)-19.6(ter )]TJ T* [(S.V)62(.\016Ochapovsky \(Kr)21.2(asnodar)1.1(, R)21(ussia\))]TJ /T1_1 1 Tf T* [(Ale)21(xander V)39.1(.\026P)10(oly)21(ak)21(o)21(v)-18(,)]TJ /T1_0 1 Tf [( Dr)48.1(. of Sci. \(Bio\), Pr)24.1(of., )]TJ T* [(corr)24(esponding member of RA)11.3(S \(Moscow)17(, R)21.1(ussia\))]TJ /T1_1 1 Tf T* [(Ale)21(xander Y)89.1(u.\026Ra)21(zumo)21(v)10(sky)13(,)]TJ /T1_0 1 Tf [( Dr)48(. of Sci. \(Med.\), )]TJ T* [(Pr)24(of., Pir)24.1(ogov National R)20.1(esear)24.1(ch Medical )]TJ T* [(Univer)11(sit)-29.9(y \(Moscow)17.1(, R)21(ussia\))]TJ /T1_1 1 Tf T* [(Vil M.\026Timerbulato)21.2(v)-18(,)]TJ /T1_0 1 Tf [( Dr)48(. of Sci. \(Med.\), Pr)24.2(of., )]TJ T* [(corr)24(esponding member of RA)11.3(S, Bashkir State )]TJ T* [(Medical Univer)11.1(sit)-29.9(y \(Ufa, R)21(ussia\))]TJ /T1_1 1 Tf T* [(Ser)11(ge)10(y A)-32(.\026F)21.1(r)10(olo)21(v)-18(,)]TJ /T1_0 1 Tf [( Dr)48(. of Sci. \(Med.\), )]TJ T* [(Ryzhikh National Medical R)20.2(esear)24.1(ch Center )]TJ T* [(of\016Colopr)24.1(octology \(Moscow)17.2(, R)21(ussia\))]TJ /T1_1 1 Tf 20.976 30 Td [(Ale)21(x)11(e)10(y S.\026T)50(sukano)21.1(v)-18(,)]TJ /T1_0 1 Tf [( Dr)48(. of Sci. \(Med\), )]TJ T* [(Ryzhikh National Medical R)20.2(esear)24.1(ch Center )]TJ T* [(of\016Colopr)24.1(octology \(Moscow)17.2(, R)21(ussia\))]TJ /T1_1 1 Tf T* [(V)42(aler)-30(y I.\026Chis)20.1(so)21(v)-18(,)]TJ /T1_0 1 Tf [( Dr)48(. of Sci. \(Med.\), Pr)24.2(of., )]TJ T* [(academician of RA)11.2(S, Sechenov Fir)11.1(st Moscow State )]TJ T* [(Medical Univer)11.1(sit)-29.9(y \(Moscow)17(, R)21.1(ussia\))]TJ /T1_1 1 Tf T* [(Adam D)11(ziki,)]TJ /T1_0 1 Tf [( MD, Pr)24(of., Medical Univer)11.2(sit)-30(y of )]TJ T* [(Lod)10(z \(Lod)10.1(z, P)7(oland\))]TJ /T1_1 1 Tf T* (Najib Haboubi,)Tj /T1_0 1 Tf [( MD, Pr)24.1(of., Univer)11.1(sit)-30(y Hospital )]TJ T* [(of South Manchester NHS F)42.3(oundation T)72.1(rust )]TJ T* [(\(Manchester)1.1(, Gr)24(eat Britain\))]TJ /T1_1 1 Tf T* [(P)10(aw)11(e\230 Mr)10(oczk)21.1(o)21(w)21(ski,)]TJ /T1_0 1 Tf [( MD, Pr)24.1(of., Chief of the )]TJ T* [(gener)21(al, viscer)21.2(al and oncology sur)24.2(ger)-31(y clinic, )]TJ T* [(DRK-Kliniken Nor)24.1(dhessen Gemeinnutzige GmbH, )]TJ T* [(Standor)-19.9(t W)41(ehlheiden \(K)42.1(assel, Germany\))]TJ /T1_1 1 Tf T* [(Gio)21(v)10(anni Romano,)]TJ /T1_0 1 Tf [( MD, Pr)24.1(of., National Cancer )]TJ T* [(Institute G.\016P)20.1(ascale \(Naples, Italy\))]TJ /T1_1 1 Tf T* [(Giulio Santor)10.1(o,)]TJ /T1_0 1 Tf [( MD, Pr)24.1(of., Univer)11.1(sit)-30(y of P)20.1(adua )]TJ T* [(\(T)72(r)24(eviso, Italy\))]TJ /T1_1 1 Tf T* [(Mar)21(ek S)10.1(zczepk)21(o)21(w)21(ski,)]TJ /T1_0 1 Tf [( MD, Pr)24.1(of., Centr)24.1(e )]TJ T* [(of\016P)7(ostgr)21.1(aduate Medical Edication in W)73.3(ar)11(saw )]TJ T* [(\(W)73(ar)11(saw)17(, P)7.1(oland\))]TJ /T1_1 1 Tf T* [(Algimantas T)59.1(amelis,)]TJ /T1_0 1 Tf [( MD, Pr)24.1(of., Lithuanian )]TJ T* [(Univer)11(sit)-29.9(y of\016Health Sciences \(K)42.2(aunas, Lithuania\))]TJ /T1_1 1 Tf T* [(Andr)21(e)10(w Zbar)84.1(,)]TJ /T1_0 1 Tf [( MD, Pr)24.1(of., Univer)11(sit)-29.9(y of Melbourne )]TJ T* [(\(Melbourne, Austr)21.2(alia\))]TJ 1 0.68 0 0.12 k /GS0 gs 0.023 Tw 14 0 0 14 120.5623 343.3674 Tm [(ADVISOR)31(Y BO)21(ARD)]TJ 0.01 Tc 0.018 Tw [( OF)5( "K)52(OL)34(OPROKT)35(OL)34(OGIA")5( JOURNAL)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0 Tc 0 Tw 8 0 0 8 36 324.8635 Tm [(F)21(uad Sh)-40.9(.\026Alie)10(v)-18(,)]TJ /T1_0 1 Tf [( Dr)48(. of Sci. \(Med.\), Pr)24.2(of., T)56.1(yumen )]TJ T* [(State Medical Univer)11.2(sit)-30(y \(T)56.1(yumen, R)21(ussia\))]TJ /T1_1 1 Tf T* [(Viktor V)39.1(.\026V)42(eselo)21(v)-18(,)]TJ /T1_0 1 Tf [( Dr)48.1(. of Sci. \(Med.\), Pr)24.1(of., )]TJ T* [(Ryzhikh National Medical R)20.2(esear)24.1(ch Center )]TJ T* [(of\016Colopr)24.1(octology \(Moscow)17.2(, R)21(ussia\))]TJ /T1_1 1 Tf T* [(V)42(aler)-30(y L.\026Denisenk)21.1(o,)]TJ /T1_0 1 Tf [( Dr)48.1(. of Sci. \(Med.\), Pr)24.2(of., )]TJ T* [(Educational Establishment Vitebsk State Or)24.4(der of )]TJ T* [(Peoples\234 F)21.1(riendship Medical Univer)11.2(sit)-29.9(y)21(, Belarusian )]TJ T* [(Medical Academy of P)7.2(ostgr)21.1(aduate Education )]TJ T* (\(Vitebsk, Belarus\))Tj /T1_1 1 Tf T* [(Irina V)39(.\026Z)31.1(ar)10(odnuk)-21(,)]TJ /T1_0 1 Tf [( Dr)48(. of Sci. \(Med.\), )]TJ T* [(Ryzhikh National Medical R)20.2(esear)24.1(ch Center )]TJ T* [(of\016Colopr)24.1(octology \(Moscow)17.2(, R)21(ussia\))]TJ /T1_1 1 Tf T* [(Ser)11(ge)10(y E.\026K)32.1(atorkin,)]TJ /T1_0 1 Tf [( Dr)48(. of Sci. \(Med.\), Samar)21.2(a )]TJ T* [(State Medical Univer)11.2(sit)-30(y \(Samar)21.1(a, R)21.1(ussia\))]TJ /T1_1 1 Tf T* [(Vladimir N)-19.9(.\026K)32(ashnik)21.1(o)20.9(v)-17.9(,)]TJ /T1_0 1 Tf [( Dr)48(. of Sci. \(Med.\), )]TJ T* [(Ryzhikh National Medical R)20.2(esear)24.1(ch Center )]TJ T* [(of\016Colopr)24.1(octology \(Moscow)17.2(, R)21(ussia\))]TJ /T1_1 1 Tf T* [(Nik)21(olay V)39(.\026K)32.1(o)21(stenk)21(o,)]TJ /T1_0 1 Tf [( Dr)48(. of Sci. \(Med.\), Pr)24.2(of., )]TJ T* [(Astr)21(akhan State Medical Univer)11.3(sit)-30(y \(Astr)21.1(akhan, )]TJ T* [(R)21(ussia\))]TJ /T1_1 1 Tf 20.976 25 Td [(Ale)21(xander M.\026K)21.1(uzmino)21(v)-17.9(,)]TJ /T1_0 1 Tf [( Dr)48(. of Sci. \(Med.\), )]TJ T* [(Pr)24(of., Ryzhikh National Medical R)20.3(esear)24.1(ch Center )]TJ T* [(of\016Colopr)24.1(octology \(Moscow)17.2(, R)21(ussia\))]TJ /T1_1 1 Tf T* [(Olga A)-31.9(.\026Maino)21(v)10(skay)21(a,)]TJ /T1_0 1 Tf ( Cand. of Sci. \(Med.\), )Tj T* [(Ryzhikh National Medical R)20.2(esear)24.1(ch Center of )]TJ T* [(Colopr)24.1(octology \(Moscow)17.1(, R)21.1(ussia\))]TJ /T1_1 1 Tf T* [(Ale)21(x)11(e)10(y I.\026Mo)21.1(skale)10(v)-18(,)]TJ /T1_0 1 Tf ( Cand. of Sci. \(Med.\), )Tj T* [(Ryzhikh National Medical R)20.2(esear)24.1(ch Center )]TJ T* [(of\016Colopr)24.1(octology \(Moscow)17.2(, R)21(ussia\))]TJ /T1_1 1 Tf T* [(Y)89(uri M.\026Stoik)21.1(o,)]TJ /T1_0 1 Tf [( Dr)48(. of Sci. \(Med.\), Pr)24.2(of., Pir)24.1(ogov )]TJ T* [(National Medical Sur)24.2(ger)-30.9(y Center \(Moscow)17.1(, )]TJ T* [(R)21(ussia\))]TJ /T1_1 1 Tf T* [(Ale)21(xander Y)89.1(u.\026Tito)21(v)-18(,)]TJ /T1_0 1 Tf [( Dr)48(. of Sci. \(Med.\), )]TJ T* [(Ryzhikh National Medical R)20.2(esear)24.1(ch Center )]TJ T* [(of\016Colopr)24.1(octology \(Moscow)17.2(, R)21(ussia\))]TJ /T1_1 1 Tf T* [(Y)89(ulia L.\026T)42.1(rubach)11(e)10(v)10(a,)]TJ /T1_0 1 Tf [( Dr)48(. of Sci. \(Med.\), )]TJ T* [(Ryzhikh National Medical R)20.2(esear)24.1(ch Center )]TJ T* [(of\016Colopr)24.1(octology \(Moscow)17.2(, R)21(ussia\))]TJ /T1_1 1 Tf T* [(Mikhail Y)89.1(u.\026F)33(edy)21(anin,)]TJ /T1_0 1 Tf [( Dr)48.1(. of Sci. \(Med.\), Blokhin )]TJ T* [(National Medical R)20.2(esear)24(ch Center of Oncology )]TJ T* [(\(Moscow)17.1(, R)21(ussia\))]TJ /T1_1 1 Tf 20.976 25 Td [(Ale)21(xander G.\026Khitar)-29.8(y)21(an,)]TJ /T1_0 1 Tf [( Dr)48(. of Sci \(Med\), Pr)24.2(of., )]TJ T* [(R)10(ostov State Medical Univer)11.3(sit)-30(y \(R)10(ostov)-20.9(-on-Don, )]TJ T* [(R)21(ussia\))]TJ /T1_1 1 Tf T* [(Dmitr)-30(y A)-31.9(.\026Kh)11(ube)21(z)10(o)21(v)-18(,)]TJ /T1_0 1 Tf [( Dr)48(. of Sci. \(Med.\), Pr)24.2(of., )]TJ T* [(Rya)10(z)10(an State Medical Univer)11.3(sit)-30(y \(Rya)10(z)10(an, R)21.1(ussia\))]TJ /T1_1 1 Tf T* [(Dmitr)-30(y V)39.1(.\026Ch)11(er)11(dantse)10(v)-18(,)]TJ /T1_0 1 Tf [( Dr)48.1(. of Sci. \(Med.\), Pr)24.1(of., )]TJ T* [(V)31(oino-)42(Y)99(asenetsky Kr)21.2(asnoyar)11(sk State Medical )]TJ T* [(Univer)11(sit)-29.9(y \(Kr)21(asnoyar)11.1(sk, R)21(ussia\))]TJ /T1_1 1 Tf T* [(Mikhail F)56.1(.\026Ch)11(erkaso)21(v)-17.9(,)]TJ /T1_0 1 Tf [( Dr)48(. of Sci. \(Med.\), Pr)24.2(of., )]TJ T* [(R)10(ostov State Medical Univer)11.3(sit)-30(y \(R)10(ostov)-20.9(-on-Don, )]TJ T* [(R)21(ussia\))]TJ /T1_1 1 Tf T* [(Marina V)39.1(.\026Shapina,)]TJ /T1_0 1 Tf ( Cand. of Sci. \(Med.\), )Tj T* [(Ryzhikh National Medical R)20.2(esear)24.1(ch Center )]TJ T* [(of\016Colopr)24.1(octology \(Moscow)17.2(, R)21(ussia\))]TJ /T1_1 1 Tf T* [(Nicolay A)-32(.\026Y)73.1(aitski,)]TJ /T1_0 1 Tf [( Dr)48.1(. of Sci. \(Med.\), Pr)24.1(of., )]TJ T* [(academician of RA)11.2(S, P)20(avlov Fir)11.1(st Saint Peter)11.1(sbur)24(g )]TJ T* [(State Medical Univer)11.2(sit)-30(y \(Saint-Peter)11.2(sbur)24(g, R)21(ussia\))]TJ /T1_1 1 Tf T* [(T)32(om\341\232 Sk\225i\226ka,)]TJ /T1_0 1 Tf [( MD, Pr)24.1(of., Medical F)42.1(acult)-29.9(y)21(, )]TJ T* [(Masar)-30.9(yk Univer)11(sit)-29.9(y Brno \(Brno, Cz)10.1(ech R)20(epublic\))]TJ ET endstream endobj 2735 0 obj <>stream BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 0.023 Tw 14 0 0 14 90.1836 747.495 Tm [(\033\034\226\026\027\017\031\037\022\022\026\025 \027)42(\037\r\r\034\021\031\025 \212\223\033\022\026)-9.9(\r\026 \253\027)42(\037\r\037\f\033\037\027)10.1(\024)35(\037\r\037\021\031\025\273)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0 Tw 8.5 0 0 8.5 36 728.991 Tm [(\202)86(\023\032\003\002\001 \035\034\036\032\031\024\240\035)]TJ 0 -1.176 TD [(\203\034\023\001\255\027\002 \204.\037)-21(.,)]TJ /T1_0 1 Tf [( \007.\215.\n., \004\205\013\202\b\006\006)11(\013\205, \220\255\220\007\b\215\002\255 \033)48(\026\022, \202\b\007\b\205\220\003\214\n\013\b \213)21(\013\006\005\007\220\205\006\t\200\b\n\n\013\b \203\230\007\206\b\t\n\013\ \b \005)10(\207\205\b\206\007\b\n\002\b \253\022\220\001\002\013\n\220\003\214\n\211\ \201 \215\b\007\002\001\002\n\006\255\002\201 )]TJ T* [(\002\006\006\003\b\007\013\200\220\t)10(\b\003\214\006\255\002\201 \001\b\n\t\205 \255)20(\013\003\013\004\205\013\255\t)10(\013\003\013\213\002\002 \002\215\b\n\002 \026.\022.\016\033\211\206\002\ \216\273 \240\002\n\002\006\t)10(\b\205\006\t\200\220 \007\205\220\200\013\013)10(\216\205\220\n\b\n\002\235 \033)20(\013\006\006\002\201\006\255)20(\013\201 \231\b\007\b\205\220\001\002\002 \(\231\021\036)38(\223 \253\022\240\031\017 )]TJ T* [(\255)20(\013\003\013\004\205\013\255\t)10.1(\013\003\013\213\002\002 \002\215\b\n\002 \026.\022.\016\033\211\206\002\ \216\273 \240\002\n\007\205\220\200\220 \033)20(\013\006\006\002\002\) \(\240\013\006\255\200\220, \033)20(\013\006\006\002\235\))]TJ /T1_1 1 Tf 0 -1.843 TD [(\215\032\205\034\033)-23(\024\027\024\034\023\027 \255)11(\023\032\003\002\240\255)11(\240 \035\034\036\032\031\024\240\035\032)]TJ 0 -1.176 TD (\037\020\031\032\033\240\003 \017.\006.,)Tj /T1_0 1 Tf [( \007.\215.\n., \004\205\013\202\b\006\006)11(\013\205, \207\003\b\n-\255)20(\013\205\205\b\006\004\013\n\007\b\n\t \033)48(\026\022, \231\021\036)38(\223 \253\022\240\031\017 \255)20(\013\003\013\004\205\013\255\t)10(\013\003\013\213\002\002 \002\215\b\n\002 \026.\022.\016\033\211\206\002\ \216\273 \240\002\n\007\205\220\200\220 \033)20(\013\006\006\002\002 )]TJ T* [(\(\240\013\006\255\200\220,\016\033)20(\013\006\006\002\235\))]TJ /T1_1 1 Tf 0 -1.118 TD [(P)10(anis Y)52(.,)]TJ /T1_0 1 Tf [( \004\205\013\202\b\006\006)11(\013\205, Univer)11(sit\351 P)20(aris VII \(\f\220\205\002\206, \231\205\220\n\001\002\235\))]TJ /T1_1 1 Tf 0 -1.843 TD [(\004\024\003\034\024\033)-23(\024\003\034\002\002\001 \033\034\031\035\034\024\032\035\201)]TJ 0 -1.176 TD [(\n\001\206\032\031)10(\240\003 \207.\202)94(.,)]TJ /T1_0 1 Tf [( \007.\215.\n., \004\205\013\202\b\006\006)11(\013\205 \033)48(\026\022, \231\021\036)38(\223 \253\022\240\031\017 \255)20(\013\003\013\004\205\013\255\t)10(\013\003\013\213\002\002 \002\215\b\n\002 \026.\022.\016\033\211\206\002\ \216\273 \240\002\n\007\205\220\200\220 \033)20(\013\006\006\002\002 \(\240\013\006\255\200\220, \033)20(\013\006\006\002\235\))]TJ /T1_1 1 Tf 8 0 0 8 36 604.9792 Tm [(\210\034\023\240\021)23(\033\240\003\032 \207.\037)-20.9(.,)]TJ /T1_0 1 Tf [( \007.\215.\n., \004\205\013\202\b\006\006)11.1(\013\205, \021\036)38.1(\223)49(\020\016\240\037 )]TJ 0 -1.125 TD [(\240\037\022\031\027\031 \002\215.\016\240.\231.\016\023\003\220\007\002\ \215\002\205\006\255)20.2(\013\213)21(\013 \(\240\013\006\255\200\220, )]TJ T* [(\033)20(\013\006\006\002\235\))]TJ /T1_1 1 Tf T* [(\210\023\032\255)11(\240\036\032\035\002\001 \b.\037)-20.9(.,)]TJ /T1_0 1 Tf [( \007.\215.\n., \004\205\013\202\b\006\006)11.1(\013\205, \231\021\036)10.1(\037)16(\223 )]TJ T* [(\226\f\037 \033)10(\240)21(\026\022\f\037 \240\002\n\007\205\220\200\220 \033)20.2(\013\006\006\002\002 \(\240\013\006\255\200\220, )]TJ T* [(\033)20(\013\006\006\002\235\))]TJ /T1_1 1 Tf T* [(\202)73(\240\023\240\003\034\002\031)10(\240 \004.\005.,)]TJ /T1_0 1 Tf [( \007.\215.\n., \004\205\013\202\b\006\006)11.1(\013\205, \231\021\036)10.1(\037)16(\223 )]TJ T* [(\226\f\037 \033)10(\240)21(\026\022\f\037 \240\002\n\007\205\220\200\220 \033)20.2(\013\006\006\002\002 \(\240\013\006\255\200\220, )]TJ T* [(\033)20(\013\006\006\002\235\))]TJ /T1_1 1 Tf T* [(\202)48(\035\027\255)11(\240\035\201\034\003 \207.\202)94.1(.,)]TJ /T1_0 1 Tf [( \007.\215.\n., \004\205\013\202\b\006\006)11.1(\013\205, \207\003\b\n-\255)20.1(\013\205\205. )]TJ T* [(\033)48(\026\022, \231\021\036)10.1(\037)16(\223 \023\037 \253\031\205\255\005)-21(\t)10(\006\255\002\201 \213)21.1(\013\006\005\007\220\205\006\t\200\b\n\n\211\201 )]TJ T* [(\215\b\007\002\001\002\n\006\255\002\201 \005\n\002\200\b\205\006\002\t)10.2(\b\t\273 \240\002\n\007\205\220\200\220 \033)20.1(\013\006\006\002\002 )]TJ T* [(\(\031\205\255\005)-21(\t)10.1(\006\255, \033)20(\013\006\006\002\235\))]TJ /T1_1 1 Tf T* [(\202)48(\035\240\211\027\023\027\002 \005.\017.,)]TJ /T1_0 1 Tf [( \007.\215.\n., \004\205\013\202\b\006\006)11.1(\013\205, \231\021\036)10.1(\037)16(\223 )]TJ T* [(\023\037 \253\033)20(\013\006\t)10.1(\013\200\006\255\002\201 \213)21(\013\006\005\007\220\205\006\t\200\b\n\n\211\201 \215\b\007\002\001\002\n\ \006\255\002\201 )]TJ T* [(\005\n\002\200\b\205\006\002\t)10.1(\b\t\273 \240\002\n\007\205\220\200\220 \033)20.1(\013\006\006\002\002 \(\033)20.1(\013\006\t)10(\013\200-\n\220)-62.9(-)]TJ T* [(\226\013\n\005)21(, \033)20(\013\006\006\002\235\))]TJ /T1_1 1 Tf T* (\006\205\022\002\027\024\240\003 \207.\t.)Tj /T1_0 1 Tf [(, \007.\215.\n., \004\205\013\202\b\006\006)11.1(\013\205, \207\003\b\n-)]TJ T* [(\255)20(\013\205\205. \033)48(\026\022, \231\021\036)38.1(\223 \253\022\240\031\017 \013\n\255)20.1(\013\003\013\213\002\002 \002\215\b\n\002 )]TJ T* [(\022.\031.\016\f\b\t\205\013\200\220\273 \240\002\n\007\205\220\200\220\ \033)20.2(\013\006\006\002\002 \(\032\220\n\255\t)-41.8(-)]TJ T* [(\f\b\t)10(\b\205\203\005\205\213)42.1(, \033)20(\013\006\006\002\235\))]TJ /T1_1 1 Tf T* [(\212)32(\032\035\032\020\021\002 \037)-20.9(.\213.,)]TJ /T1_0 1 Tf [( \007.\215.\n., \004\205\013\202\b\006\006)11.1(\013\205, \231\021\036)38.1(\223 )]TJ T* [(\253\022\240\031\017 \013\n\255)20.1(\013\003\013\213\002\002 \002\215.\016\022.\022.\016\f\b\t\205\013\200\220\ \273 )]TJ T* [(\240\002\n\007\205\220\200\220 \033)20.1(\013\006\006\002\002 \(\032\220\n\255\t)-41.9(-\f\b\t)10(\b\205\203\005\205\213)42.1(, \033)20(\013\006\006\002\235\))]TJ /T1_1 1 Tf T* [(\212)32(\032\035\217\021)23(\214)12(\027\002 \004.\204.,)]TJ /T1_0 1 Tf [( \007.\215.\n., \004\205\013\202\b\006\006)11.1(\013\205, \231\021\036)10.1(\037)16(\223 )]TJ T* [(\023\037 \253\027)42(\220\220\n\006\255\002\201 \213)21.1(\013\006\005\007\220\205\006\t\200\b\n\n\211\201 \215\b\007\002\001\002\n\ \006\255\002\201 )]TJ T* [(\005\n\002\200\b\205\006\002\t)10.1(\b\t\273 \240\002\n\007\205\220\200\220 \033)20.1(\013\006\006\002\002 \(\027)42.1(\220\220\n\214, )]TJ T* [(\033)20(\013\006\006\002\235\))]TJ /T1_1 1 Tf T* [(\213\240\035\240)23(\025\240\003 \216.\037)-20.9(.,)]TJ /T1_0 1 Tf [( \007.\215.\n., \004\205\013\202\b\006\006)11.1(\013\205, \231\021)80.1(\026\037)16(\223 \023\037 )]TJ T* [(\253\f\b\205\200\211\201 \240\021)31.1(\240)42(\223 \002\215. \031.\240.\016\032\b\207\b\n\013\200\220\273 \240\002\n\007\ \205\220\200\220 )]TJ T* [(\033)20(\013\006\006\002\002 \(\032\b\207\b\n\013\200\006\255\002\201 \005\n\002\ \200\b\205\006\002\t)10.3(\b\t\) \(\240\013\006\255\200\220, )]TJ T* [(\033)20(\013\006\006\002\235\))]TJ /T1_1 1 Tf 20.976 34.875 Td [(\213)21(\021\035\032\003\201\034\003 \037)-20.9(.\005.,)]TJ /T1_0 1 Tf [( \007.\215.\n., \004\205\013\202\b\006\006)11.1(\013\205, \231\021\036)10.1(\037)16(\223 \023\037 )]TJ T* [(\253\032)21(\t)13(\220\200\205\013\004\013\003\214\006\255\002\201 \213)21.1(\013\006\005\007\220\205\006\t\200\b\n\n\211\201 \215\b\007\002\001\002\n\ \006\255\002\201 )]TJ T* [(\005\n\002\200\b\205\006\002\t)10.1(\b\t\273 \240\002\n\007\205\220\200\220 \033)20.1(\013\006\006\002\002 \(\032)21.1(\t)13(\220\200\205\013\004\013\003\214, )]TJ T* [(\033)20(\013\006\006\002\235\))]TJ /T1_1 1 Tf T* (\004\205\034\023\201\022\002\240\003\033\031\027 \005.\005.,)Tj /T1_0 1 Tf [( \007.\215.\n., \004\205\013\202\b\006\006)11.2(\013\205, )]TJ T* [(\231\021\036)38(\223 \253\017\b\n\t\205 \210\255)21.1(\006\004\b\205)10.1(\t\002\211 \002 \255)20(\013\n\t\205\013\003\235 \255\220\207\b\006\t\200\220 )]TJ T* [(\215\b\007\002\001\002\n\006\255)20.1(\013\201 \004\013\215\013\221\002\273 \240\002\n\007\205\220\200\220 \033\ )20.2(\013\006\006\002\002, )]TJ T* [(\231\021\036)10(\037)16(\223 \226\f\037 \033)10.1(\240)21(\026\022\f\037 \240\002\n\007\205\220\200\220 \033)20.1(\013\006\006\002\002 )]TJ T* [(\(\240\013\006\255\200\220, \033)20.1(\013\006\006\002\235\))]TJ /T1_1 1 Tf T* [(\200\240\036)-34(\036\021\206\002\001 \006.\005.,)]TJ /T1_0 1 Tf [( \007.\215.\n., \004\205\013\202\b\006\006)11.1(\013\205, \231\021\036)10.1(\037)16(\223 )]TJ T* [(\023\037 \253\240\021)31(\240\032\223 \002\215.\016\026.\031.\016\034\200\007\013\255\002\215\013\ \200\220\273 \240\002\n\007\205\220\200\220 )]TJ T* [(\033)20(\013\006\006\002\002 \(\240\013\006\255\200\220, \033)20.2(\013\006\006\002\235\))]TJ /T1_1 1 Tf T* (\200\240\023\240\003\027\002\031\027\002 \005.\005.,)Tj /T1_0 1 Tf [( \007.\215.\n., \004\205\013\202\b\006\006)11.1(\013\205, \021\036)38.1(\223)49(\020 )]TJ T* [(\253\022\220\005)10(\207\n\013-\002\006\006\003\b\007\013\200\220\t)10.2(\b\003\214\006\255\002\201 \002\n\006\t\002\t)-19.9(\005)-21(\t\016\227 )]TJ T* [(\027)20(\205\220\b\200\220\235 \255)-10.9(\003\002\n\002\207\b\006\255\220\235 \203\013\003\214\n\002\001\220 \217\ \0161 )]TJ T* [(\002\215.\016\004\205\013\202. \032.\023.\016\037\207\220\004\013\200\006\ \255)20.2(\013\213)21(\013\273 \240\002\n\002\006\t)10.1(\b\205\006\t\200\220 )]TJ T* [(\007\205\220\200\013\013)10.1(\216\205\220\n\b\n\002\235 \027)20(\205\220\006\n\013\007\220\205\006\255)20.2(\013\213)21(\013 \255\205\220\235 )]TJ T* [(\(\027)20(\205\220\006\n\013\007\220\205, \033)20.1(\013\006\006\002\235\))]TJ /T1_1 1 Tf T* [(\200\240\023\022\031)10(\240\003 \037)-21(.\005.)]TJ /T1_0 1 Tf [(, \007.\203.\n., \004\205\013\202\b\006\006)11.1(\013\205, \207\003\b\n-\255)20.1(\013\205\205. )]TJ T* [(\033)48(\026\022, \231\021\036\022\223 \253\240\b\007\002\255)20.1(\013-\213\b\n\b\t\002\207\b\006\255\002\201 \n\220\005)10.2(\207\n\211\201 )]TJ T* [(\001\b\n\t\205 \002\215\b\n\002 \220\255\220\007\b\215\002\255\220 \022.\ \f.\016\036\013\207\255)20.3(\013\200\220\273 \(\240\013\006\255\200\220, )]TJ T* [(\033)20(\013\006\006\002\235\))]TJ /T1_1 1 Tf T* [(\n)20(\032\025)10(\021\205)-11(\240\003\033\031\027 \037)-20.9(.\204.,)]TJ /T1_0 1 Tf [( \007.\215.\n., \004\205\013\202\b\006\006)11.1(\013\205, )]TJ T* [(\207\003\b\n-\255)20(\013\205\205. \033)48.1(\026\022, \231\021)80(\026\037)16(\223 \023\037 \033\022\031\240)42.1(\223 )]TJ T* [(\002\215.\016\022.\031.\016\f\002\205\013\213)21.1(\013\200\220 \240\002\n\007\205\220\200\220 \033)20.2(\013\006\006\002\002 \(\240\013\006\255\200\220, )]TJ T* [(\033)20(\013\006\006\002\235\))]TJ /T1_1 1 Tf T* [(\r)21(\027\205\034\035\206\021\023\032\024\240\003 \005.\213.,)]TJ /T1_0 1 Tf [( \007.\215.\n., \004\205\013\202\b\006\006)11.2(\013\205, )]TJ T* [(\207\003\b\n-\255)20(\013\205\205. \033)48.1(\026\022, \231\021\036)10(\037)16(\223 \023\037 \253\036\220\222\255\002\205\006\255\002\201 )]TJ T* [(\213)21(\013\006\005\007\220\205\006\t\200\b\n\n\211\201 \215\b\007\002\001\002\n\ \006\255\002\201 \005\n\002\200\b\205\006\002\t)10.3(\b\t\273 )]TJ T* [(\240\002\n\007\205\220\200\220 \033)20.1(\013\006\006\002\002 \(\223)73.1(\202\220, \033)20(\013\006\006\002\235\))]TJ /T1_1 1 Tf T* [(\221\035\240\023\240\003 \017.\037)-20.9(.,)]TJ /T1_0 1 Tf [( \007.\215.\n., \231\021\036)38.1(\223 \253\022\240\031\017 )]TJ T* [(\255)20(\013\003\013\004\205\013\255\t)10.1(\013\003\013\213\002\002 \002\215\b\n\002 \026.\022.\016\033\211\206\002\ \216\273 \240\002\n\007\205\220\200\220 )]TJ T* [(\033)20(\013\006\006\002\002 \(\240\013\006\255\200\220, \033)20.2(\013\006\006\002\235\))]TJ /T1_1 1 Tf 20.976 36 Td [(\222\021\031\032\002\240\003 \037)-20.9(.\017.)]TJ /T1_0 1 Tf [(, \007.\215.\n., \231\021\036)38.1(\223 \253\022\240\031\017 )]TJ T* [(\255)20(\013\003\013\004\205\013\255\t)10.1(\013\003\013\213\002\002 \002\215\b\n\002 \026.\022.\016\033\211\206\002\ \216\273 \240\002\n\007\205\220\200\220 )]TJ T* [(\033)20(\013\006\006\002\002 \(\240\013\006\255\200\220, \033)20.2(\013\006\006\002\235\))]TJ /T1_1 1 Tf T* (\223\027\033\033\240\003 \005.\006.,)Tj /T1_0 1 Tf [( \007.\215.\n., \004\205\013\202\b\006\006)11.1(\013\205, \220\255\220\007\b\215\002\255 \033)48.1(\026\022, )]TJ T* [(\231\021)80(\026\037)16(\223 \023\037 \253\f\b\205\200\211\201 \240\021)31.1(\240)42(\223 \002\215.\016\031.\240.\016\032\b\207\b\n\013\200\220\273 )]TJ T* [(\240\002\n\007\205\220\200\220 \033)20.1(\013\006\006\002\002 \(\032\b\207\b\n\013\200\006\255\002\201 \005\n\002\ \200\b\205\006\002\t)10.3(\b\t\) )]TJ T* [(\(\240\013\006\255\200\220, \033)20.1(\013\006\006\002\235\))]TJ /T1_1 1 Tf T* [(D)11(ziki A)-32(.,)]TJ /T1_0 1 Tf [( \004\205\013\202\b\006\006)11(\013\205, Medical Univer)11.2(sit)-30(y of Lod)10.1(z )]TJ T* (\(\r\013\007\214, \f\013\003\214\222\220\))Tj /T1_1 1 Tf T* [(Haboubi N)-19.9(.,)]TJ /T1_0 1 Tf [( \004\205\013\202\b\006\006)11.1(\013\205, Univer)11.1(sit)-30(y Hospital )]TJ T* [(of South Manchester NHS F)42.3(oundation T)72.1(rust )]TJ T* [(\(\240\220\n\207\b\006\t)10.1(\b\205, \023\b\003\002\255)20(\013\203\205\002\t)13.1(\220\n\002\235\))]TJ /T1_1 1 Tf T* [(Mr)10(oczk)21(o)21(w)21(ski P)73.1(.,)]TJ /T1_0 1 Tf [( \004\205\013\202\b\006\006)11.1(\013\205, \205\005\255)20(\013\200\013\007\002\t)10.1(\b\003\214 )]TJ T* [(\255)-11(\003\002\n\002\255\002 \013\203\221\b\201, \200\002\006\001\b\205\220\003\ \214\n\013\201 \002 \013\n\255)20.3(\013\003\013\213\002\207\b\006\255)20.1(\013\201 )]TJ T* [(\216\002\205\005\205\213\002\002, DRK-Kliniken Nor)24.2(dhessen )]TJ T* [(Gemeinnutzige GmbH, Standor)-19.7(t W)41(ehlheiden )]TJ T* [(\(\027)42(\220\006\006\b\003\214, \021)114.1(\b\205\215\220\n\002\235\))]TJ /T1_1 1 Tf T* (Romano G.,)Tj /T1_0 1 Tf [( \004\205\013\202\b\006\006)11(\013\205, National Cancer )]TJ T* [(Institute G.\016P)20.1(ascale \(\022\b\220\004\013\003\214, \031\t)13.2(\220\003\002\235\))]TJ /T1_1 1 Tf T* [(Santor)10(o G.,)]TJ /T1_0 1 Tf [( \004\205\013\202\b\006\006)11.1(\013\205, Univer)11.1(sit)-30(y of P)20(adua )]TJ T* [(\(\024)50(\205\b\200\002\013, \031\t)13.1(\220\003\002\235\))]TJ /T1_1 1 Tf T* [(S)10(zczepk)21(o)21(w)21(ski M.,)]TJ /T1_0 1 Tf [( \004\205\013\202\b\006\006)11.1(\013\205, Centr)24.1(e )]TJ T* [(of\016P)7(ostgr)21.1(aduate Medical Edication in W)73.3(ar)11(saw )]TJ T* (\(\023\220\205\222\220\200\220, \f\013\003\214\222\220\))Tj /T1_1 1 Tf T* [(T)59(amelis A)-31.9(.,)]TJ /T1_0 1 Tf [( \004\205\013\202\b\006\006)11.1(\013\205, Lithuanian Univer)11.2(sit)-30(y of )]TJ T* [(Health Sciences \(\027)42.2(\220\005\n\220\006, \r\002\t\200\220\))]TJ /T1_1 1 Tf T* [(Zbar A)-32(.,)]TJ /T1_0 1 Tf [( \004\205\013\202\b\006\006)11(\013\205, Univer)11.1(sit)-29.9(y of Melbourne )]TJ 0 -1.15 TD (\(\240\b\003\214\203\005\205\n, \026\200\006\t\205\220\003\002\235\))Tj 1 0.68 0 0.12 k /GS0 gs 0.023 Tw 14 0 0 14 100.8305 286.1367 Tm [(\033\034\226\026\027\017\031\037\022\022\232\030 \032\037\023\034)-31(\024 \212\223\033\022\026)-10(\r\026 \253\027)42(\037\r\037\f\033\037\027)10.1(\024)34.9(\037\r\037\021\031\025\273)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0 Tw 8 0 0 8 36 268.6328 Tm [(\037)-11(\023\027\034\003 \221.\203.,)]TJ /T1_0 1 Tf [( \007.\215.\n., \004\205\013\202\b\006\006)11.1(\013\205, \231\021\036)10.1(\037)16(\223 \023\037 )]TJ 0 -1.125 TD [(\253\024)50(\230\215\b\n\006\255\002\201 \213)21.1(\013\006\005\007\220\205\006\t\200\b\n\n\211\201 \215\b\007\002\001\002\n\ \006\255\002\201 )]TJ T* [(\005\n\002\200\b\205\006\002\t)10.1(\b\t\273 \240\002\n\007\205\220\200\220 \033)20.1(\013\006\006\002\002 \(\024)50.1(\230\215\b\n\214, )]TJ T* [(\033)20(\013\006\006\002\235\))]TJ /T1_1 1 Tf T* (\005\034\033\034\023\240\003 \005.\005.,)Tj /T1_0 1 Tf [( \007.\215.\n., \004\205\013\202\b\006\006)11.1(\013\205, \231\021\036)38.1(\223 \253\022\240\031\017 )]TJ T* [(\255)20(\013\003\013\004\205\013\255\t)10.1(\013\003\013\213\002\002 \002\215\b\n\002 \026.\022.\016\033\211\206\002\ \216\273 \240\002\n\007\205\220\200\220 )]TJ T* [(\033)20(\013\006\006\002\002 \(\240\013\006\255\200\220, \033)20.2(\013\006\006\002\235\))]TJ /T1_1 1 Tf T* [(\216\034\002\027\033\034\002\031)10(\240 \005.\b.,)]TJ /T1_0 1 Tf [( \007.\215.\n., \004\205\013\202\b\006\006)11.1(\013\205 )]TJ T* [(\255\220\202\b\007\205\211 \013\203\221\b\201 \216\002\205\005\205\213\002\ \002 \223)2.3(\037 \253\023\002\t)10(\b\203\006\255\002\201 )]TJ T* [(\213)21(\013\006\005\007\220\205\006\t\200\b\n\n\211\201 \215\b\007\002\001\002\n\ \006\255\002\201 \005\n\002\200\b\205\006\002\t)10.3(\b\t\273 )]TJ T* [(\(\023\002\t)10(\b\203\006\255, \036\b\003\220\205\005\006\214\))]TJ /T1_1 1 Tf T* (\215\032\035\240\036\002\220\031 \006.\005.,)Tj /T1_0 1 Tf [( \007.\215.\n., \231\021\036)38.1(\223 \253\022\240\031\017 )]TJ T* [(\255)20(\013\003\013\004\205\013\255\t)10.1(\013\003\013\213\002\002 \002\215\b\n\002 \026.\022.\016\033\211\206\002\ \216\273 \240\002\n\007\205\220\200\220 )]TJ T* [(\033)20(\013\006\006\002\002 \(\240\013\006\255\200\220, \033)20.2(\013\006\006\002\235\))]TJ /T1_1 1 Tf T* [(\212)32(\032\024\240\035\031\027\002 \017.\207.,)]TJ /T1_0 1 Tf [( \007.\215.\n., \231\021\036)10.1(\037)16(\223 \023\037 \253\032\220\215\220\205\006\255\002\201 )]TJ T* [(\213)21(\013\006\005\007\220\205\006\t\200\b\n\n\211\201 \215\b\007\002\001\002\n\ \006\255\002\201 \005\n\002\200\b\205\006\002\t)10.3(\b\t\273 )]TJ T* [(\240\002\n\007\205\220\200\220 \033)20.1(\013\006\006\002\002 \(\032\220\215\220\205\220, \033)20.2(\013\006\006\002\235\))]TJ /T1_1 1 Tf T* [(\212)32(\032\211\002\027\031)10(\240\003 \005.\t.,)]TJ /T1_0 1 Tf [( \007.\215.\n., \231\021\036)38.1(\223 \253\022\240\031\017 )]TJ T* [(\255)20(\013\003\013\004\205\013\255\t)10.1(\013\003\013\213\002\002 \002\215\b\n\002 \026.\022.\016\033\211\206\002\ \216\273 \240\002\n\007\205\220\200\220 )]TJ T* [(\033)20(\013\006\006\002\002 \(\240\013\006\255\200\220, \033)20.2(\013\006\006\002\235\))]TJ /T1_1 1 Tf T* [(\212)31(\240\033)-23(\024\034\002\031)10(\240 \t.\005.,)]TJ /T1_0 1 Tf [( \007.\215.\n., \004\205\013\202\b\006\006)11.1(\013\205, \231\021\036)10.1(\037)16(\223 \023\037 )]TJ T* [(\253\026\006\t\205\220\216\220\n\006\255\002\201 \213)21.1(\013\006\005\007\220\205\006\t\200\b\n\n\211\201 \215\b\007\002\001\002\n\ \006\255\002\201 )]TJ T* [(\005\n\002\200\b\205\006\002\t)10.1(\b\t\273 \240\002\n\007\205\220\200\220 \033)20.1(\013\006\006\002\002 \(\026\006\t\205\220\216\220\n\214, )]TJ T* [(\033)20(\013\006\006\002\235\))]TJ /T1_1 1 Tf 20.976 25.875 Td [(\212)53(\021)23(\025\201\205\027\002\240\003 \037)-20.9(.\213.,)]TJ /T1_0 1 Tf [( \007.\215.\n., \004\205\013\202\b\006\006)11.1(\013\205, \231\021\036)38.1(\223 )]TJ T* [(\253\022\240\031\017 \255)20.1(\013\003\013\004\205\013\255\t)10(\013\003\013\213\002\002 \002\215\b\n\002 \026.\022.\016\033\211\206\002\ \216\273 )]TJ T* [(\240\002\n\007\205\220\200\220 \033)20.1(\013\006\006\002\002 \(\240\013\006\255\200\220, \033)20.2(\013\006\006\002\235\))]TJ /T1_1 1 Tf T* [(\213\032\002\240\003\033\031\032\022 \004.\037)-20.9(.,)]TJ /T1_0 1 Tf [( \255.\215.\n., \231\021\036)38.1(\223 \253\022\240\031\017 )]TJ T* [(\255)20(\013\003\013\004\205\013\255\t)10.1(\013\003\013\213\002\002 \002\215\b\n\002 \026.\022.\016\033\211\206\002\ \216\273 \240\002\n\007\205\220\200\220 )]TJ T* [(\033)20(\013\006\006\002\002 \(\240\013\006\255\200\220, \033)20.2(\013\006\006\002\235\))]TJ /T1_1 1 Tf T* [(\213\240\033\031\032\023\034\003 \037)-20.9(.\006.,)]TJ /T1_0 1 Tf [( \255.\215.\n., \231\021\036)38.1(\223 \253\022\240\031\017 )]TJ T* [(\255)20(\013\003\013\004\205\013\255\t)10.1(\013\003\013\213\002\002 \002\215\b\n\002 \026.\022.\016\033\211\206\002\ \216\273 \240\002\n\007\205\220\200\220 )]TJ T* [(\033)20(\013\006\006\002\002 \(\240\013\006\255\200\220, \033)20.2(\013\006\006\002\235\))]TJ /T1_1 1 Tf T* [(\017\024\240\031)10(\240 \204.\213.,)]TJ /T1_0 1 Tf [( \007.\215.\n., \004\205\013\202\b\006\006)11.1(\013\205, \231\021\036)38.1(\223 )]TJ T* [(\253\022\240\233\017 \002\215.\016\022.\031.\016\f\002\205\013\213)21.2(\013\200\220\273 \240\002\n\007\205\220\200\220 \033)20.1(\013\006\006\002\002 )]TJ T* [(\(\240\013\006\255\200\220, \033)20.1(\013\006\006\002\235\))]TJ /T1_1 1 Tf T* [(\r)21(\027\024\240\003 \037)-21(.\204.,)]TJ /T1_0 1 Tf [( \007.\215.\n., \231\021\036)38.1(\223 \253\022\240\031\017 )]TJ T* [(\255)20(\013\003\013\004\205\013\255\t)10.1(\013\003\013\213\002\002 \002\215\b\n\002 \026.\022.\016\033\211\206\002\ \216\273 \240\002\n\007\205\220\200\220 )]TJ T* [(\033)20(\013\006\006\002\002 \(\240\013\006\255\200\220, \033)20.2(\013\006\006\002\235\))]TJ /T1_1 1 Tf T* [(\r)21(\035\021\206\032\020\034\003\032 \204.\b.,)]TJ /T1_0 1 Tf [( \007.\215.\n., \231\021\036)38.1(\223 \253\022\240\031\017 )]TJ T* [(\255)20(\013\003\013\004\205\013\255\t)10.1(\013\003\013\213\002\002 \002\215\b\n\002 \026.\022.\016\033\211\206\002\ \216\273 \240\002\n\007\205\220\200\220 )]TJ T* [(\033)20(\013\006\006\002\002 \(\240\013\006\255\200\220, \033)20.2(\013\006\006\002\235\))]TJ /T1_1 1 Tf T* (\221\034\036\022\002\027\002 \213.\204.,)Tj /T1_0 1 Tf [( \007.\215.\n., \231\021\036)38.1(\223 \253\022\240\031\017 )]TJ T* [(\013\n\255)20(\013\003\013\213\002\002 \002\215.\016\022.\022.\016\036\003\013)10.2(\216\002\n\220\273 \240\002\n\007\205\220\200\220 \033)20.1(\013\006\006\002\002 )]TJ T* [(\(\240\013\006\255\200\220, \033)20.1(\013\006\006\002\235\))]TJ /T1_1 1 Tf T* [(\007\027\024\032\035\201\022\002 \037)-20.9(.\202)94(.)]TJ /T1_0 1 Tf [(, \007.\215.\n., \004\205\013\202\b\006\006)11.1(\013\205, \231\021\036)10.1(\037)16(\223 \023\037 )]TJ T* [(\253\033)20(\013\006\t)10(\013\200\006\255\002\201 \213)21.1(\013\006\005\007\220\205\006\t\200\b\n\n\211\201 \215\b\007\002\001\002\n\ \006\255\002\201 )]TJ T* [(\005\n\002\200\b\205\006\002\t)10.1(\b\t\273 \240\002\n\007\205\220\200\220 \033)20.1(\013\006\006\002\002 \(\033)20.1(\013\006\t)10(\013\200-\n\220)-62.9(-)]TJ T* [(\226\013\n\005)21(, \033)20(\013\006\006\002\235\))]TJ /T1_1 1 Tf 20.976 27 Td [(\007)42(\021\206\034\025\240\003 \216.\037)-20.9(.,)]TJ /T1_0 1 Tf [( \007.\215.\n., \004\205\013\202\b\006\006)11.1(\013\205, \231\021\036)10.1(\037)16(\223 \023\037 )]TJ T* [(\253\033)20(\235\220\n\006\255\002\201 \213)21.1(\013\006\005\007\220\205\006\t\200\b\n\n\211\201 \215\b\007\002\001\002\n\ \006\255\002\201 )]TJ T* [(\005\n\002\200\b\205\006\002\t)10.1(\b\t\273 \240\002\n\007\205\220\200\220 \033)20.1(\013\006\006\002\002 \(\033)20.1(\235\220\n\214, )]TJ T* [(\033)20(\013\006\006\002\235\))]TJ /T1_1 1 Tf T* (\223\034\035\036\032\002\030\034\003 \216.\005.,)Tj /T1_0 1 Tf [( \007.\215.\n., \004\205\013\202\b\006\006)11.1(\013\205, \231\021\036)10.1(\037)16(\223 \023\037 )]TJ T* [(\253\027)20(\205\220\006\n\013\235\205\006\255\002\201 \213)21.1(\013\006\005\007\220\205\006\t\200\b\n\n\211\201 \215\b\007\002\001\002\n\ \006\255\002\201 )]TJ T* [(\005\n\002\200\b\205\006\002\t)10.1(\b\t \002\215.\016\004\205\013\202. \023.\231.\016\023\013\201\n\013-\025\ \006\b\n\b\001\255)20.2(\013\213)21(\013\273 )]TJ T* [(\240\002\n\007\205\220\200\220 \033)20.1(\013\006\006\002\002 \(\027)20.1(\205\220\006\n\013\235\205\006\255, \033)20.1(\013\006\006\002\235\))]TJ /T1_1 1 Tf T* (\223\034\035\031\032\033\240\003 \213.\221.,)Tj /T1_0 1 Tf [( \007.\215.\n., \004\205\013\202\b\006\006)11.1(\013\205, \231\021\036)10.1(\037)16(\223 )]TJ T* [(\023\037 \253\033)20(\013\006\t)10.1(\013\200\006\255\002\201 \213)21(\013\006\005\007\220\205\006\t\200\b\n\n\211\201 \215\b\007\002\001\002\n\ \006\255\002\201 )]TJ T* [(\005\n\002\200\b\205\006\002\t)10.1(\b\t\273 \240\002\n\007\205\220\200\220 \033)20.1(\013\006\006\002\002 \(\033)20.1(\013\006\t)10(\013\200-\n\220)-62.9(-)]TJ T* [(\226\013\n\005)21(, \033)20(\013\006\006\002\235\))]TJ /T1_1 1 Tf T* (\203\032\217\027\002\032 \213.\005.,)Tj /T1_0 1 Tf [( \255.\215.\n., \231\021\036)38.1(\223 \253\022\240\031\017 )]TJ T* [(\255)20(\013\003\013\004\205\013\255\t)10.1(\013\003\013\213\002\002 \002\215\b\n\002 \026.\022.\016\033\211\206\002\ \216\273 \240\002\n\007\205\220\200\220 )]TJ T* [(\033)20(\013\006\006\002\002 \(\240\013\006\255\200\220, \033)20.2(\013\006\006\002\235\))]TJ /T1_1 1 Tf T* [(\224\027\030\031\027 \t.\037)-21(.,)]TJ /T1_0 1 Tf [( \007.\215.\n., \004\205\013\202\b\006\006)11.1(\013\205, \220\255\220\007\b\215\002\255 )]TJ T* [(\033)48(\026\022, \231\021\036)10.1(\037)16(\223 \023\037 \253\f\b\205\200\211\201 \032\220\n\255\t)-41.9(-\f\b\t)10(\b\205\203\005\205\213)21.1(\006\255\002\201 )]TJ T* [(\213)21(\013\006\005\007\220\205\006\t\200\b\n\n\211\201 \215\b\007\002\001\002\n\ \006\255\002\201 \005\n\002\200\b\205\006\002\t)10.3(\b\t )]TJ T* [(\002\215.\016\220\255\220\007.\016\031.\f.\016\f\220\200\003\013\200\220\ \273 \240\002\n\007\205\220\200\220 \033)20.3(\013\006\006\002\002 )]TJ T* [(\(\032\220\n\255\t)-42(-\f\b\t)10.1(\b\205\203\005\205\213)42(, \033)20.1(\013\006\006\002\235\))]TJ /T1_1 1 Tf T* [(Sk\225i\226ka T)20.1(.,)]TJ /T1_0 1 Tf [( \004\205\013\202\b\006\006)11.1(\013\205, Medical F)42.1(acult)-29.9(y)21(, Masar)-30.9(yk )]TJ T* [(Univer)11(sit)-29.9(y Brno \(\036\205\n\013, \224\b\216\002\235\))]TJ ET endstream endobj 2732 0 obj <>stream BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 0.023 Tw 16 0 0 16 177.0521 590.8799 Tm [(R)21(ussian Journal of Colopr)24(octology)]TJ /T1_1 1 Tf 0 Tw 33 0 0 33 136.3186 554.8799 Tm [(K)20(OL)30(OPROKT)20(OL)30(OGIA)]TJ /T1_0 1 Tf 0.023 Tw 22 0 0 22 198.0489 528.4799 Tm [(vol. 2)38(3, \217\016)-23.3(1)75(, 2)25(02)50(4)]TJ ET 1 0.68 0 0.12 K 4 M 99.713 516.406 367.504 98.213 re S /PlacedPDF /MC0 BDC q 220.701 637.795 125.528 93.521 re W n /GS1 gs q 1 0 0 1 339.3942 663.3804 cm 0 0 m -0.546 -1.137 l -2.555 1.733 l -4.222 2.533 l -3.719 3.581 l -2.053 2.78 l 1.468 3.057 l 0.897 1.868 l -1.464 1.854 l h -0.197 4.914 m -2.733 5.72 l -2.473 6.541 l -1.972 6.382 l -1.968 6.395 l -2.342 6.858 -2.357 7.364 -2.152 8.011 c -1.509 10.034 0.176 9.808 1.062 9.525 c 2.011 9.224 3.4 8.37 2.736 6.281 c 2.306 4.926 1.27 4.624 0.437 4.757 c 0.803 5.911 l 0.994 5.865 1.584 5.803 1.83 6.577 c 2.238 7.859 0.919 8.263 0.652 8.347 c 0.371 8.437 -0.898 8.811 -1.283 7.603 c -1.436 7.122 -1.338 6.503 -0.71 6.237 c -0.413 7.173 l 0.435 6.903 l h 1.497 11.908 m 1.934 11.844 3.126 11.717 3.299 12.888 c 3.393 13.519 3.139 14.15 1.857 14.34 c 0.59 14.527 0.149 13.998 0.057 13.367 c -0.115 12.203 1.089 11.969 1.497 11.908 c 2.04 15.58 m 3.17 15.413 4.524 14.66 4.241 12.748 c 3.994 11.079 2.783 10.457 1.314 10.675 c -0.153 10.892 -1.133 11.837 -0.886 13.507 c -0.603 15.419 0.911 15.747 2.04 15.58 c -0.411 16.52 m -0.34 19.957 l 4.562 19.856 l 4.537 18.701 l 0.588 18.782 l 0.541 16.5 l h 1.896 22.527 m 2.333 22.588 3.513 22.8 3.352 23.972 c 3.265 24.604 2.844 25.14 1.561 24.963 c 0.291 24.787 0.018 24.156 0.104 23.524 c 0.266 22.359 1.486 22.471 1.896 22.527 c 1.39 26.205 m 2.521 26.36 4.031 26.017 4.295 24.102 c 4.525 22.431 3.537 21.495 2.066 21.292 c 0.596 21.09 -0.609 21.723 -0.84 23.395 c -1.104 25.309 0.259 26.049 1.39 26.205 c 1.604 31.055 m 2.522 31.309 l 3.622 27.34 l 2.704 27.086 l 2.31 28.51 l -1.498 27.455 l -1.806 28.568 l 2.001 29.623 l h -0.748 31.128 m -1.455 30.91 -2.66 30.844 -3.344 32.441 c -3.836 33.594 -3.76 34.876 -1.988 35.633 c 0.389 36.648 1.222 34.947 1.406 34.517 c 2.088 32.919 1.264 32.086 0.614 31.771 c 0.169 32.814 l 0.881 33.232 0.657 33.846 0.553 34.09 c 0.45 34.329 0.047 35.146 -1.459 34.503 c -2.31 34.14 -2.756 33.492 -2.448 32.771 c -2.15 32.075 -1.555 32.087 -1.199 32.184 c h -3.065 37.751 m -2.688 37.981 -1.689 38.645 -2.305 39.656 c -2.635 40.201 -3.234 40.525 -4.342 39.853 c -5.437 39.188 -5.437 38.5 -5.105 37.955 c -4.496 36.949 -3.418 37.537 -3.065 37.751 c -4.992 40.925 m -4.017 41.517 -2.492 41.802 -1.49 40.15 c -0.614 38.708 -1.149 37.456 -2.418 36.686 c -3.688 35.915 -5.045 36.018 -5.92 37.46 c -6.924 39.112 -5.969 40.332 -4.992 40.925 c -7.355 44.355 m -6.693 43.531 l -6.286 43.022 -5.936 43.188 -5.749 43.338 c -5.371 43.64 -5.437 43.955 -5.748 44.344 c -6.383 45.136 l h -6.363 46.633 m -4.795 44.678 l -4.482 44.289 -3.85 43.298 -4.839 42.505 c -5.483 41.988 -6.041 42.224 -6.33 42.404 c -6.341 42.396 l -6.068 41.743 -6.557 41.334 -6.831 41.104 c -7.309 40.703 -7.467 40.576 -7.555 40.282 c -8.291 41.2 l -8.182 41.557 -7.986 41.615 -7.44 42.133 c -7.012 42.539 -7.416 42.998 -7.498 43.102 c -8.055 43.795 l -9.465 42.664 l -10.188 43.566 l h -11.069 48.253 m -10.429 47.616 l -10.041 47.231 -9.704 47.173 -9.368 47.511 c -8.899 47.982 -9.321 48.362 -9.506 48.546 c -10.146 49.183 l h -8.676 49.063 m -7.971 48.362 -7.625 47.497 -8.479 46.638 c -9.561 45.549 -10.538 46.382 -10.961 46.802 c -11.74 47.577 l -12.93 46.38 l -13.75 47.193 l -10.295 50.672 l h -13.953 50.599 m -13.678 50.942 -12.97 51.909 -13.895 52.647 c -14.394 53.045 -15.067 53.144 -15.875 52.13 c -16.674 51.128 -16.437 50.481 -15.938 50.085 c -15.019 49.351 -14.211 50.274 -13.953 50.599 c -16.855 52.912 m -16.145 53.805 -14.813 54.597 -13.301 53.392 c -11.982 52.341 -12.053 50.981 -12.979 49.821 c -13.904 48.659 -15.213 48.288 -16.532 49.34 c -18.043 50.545 -17.567 52.019 -16.855 52.912 c -18.906 51.336 m -21.785 53.217 l -19.104 57.322 l -18.137 56.689 l -20.297 53.383 l -18.385 52.134 l h -22.668 56.567 m -22.461 56.958 -21.941 58.038 -22.986 58.594 c -23.549 58.894 -24.229 58.866 -24.838 57.723 c -25.44 56.591 -25.089 56 -24.526 55.7 c -23.487 55.147 -22.862 56.203 -22.668 56.567 c -25.945 58.312 m -25.409 59.319 -24.245 60.343 -22.539 59.435 c -21.049 58.642 -20.869 57.293 -21.567 55.982 c -22.265 54.671 -23.484 54.066 -24.974 54.859 c -26.68 55.768 -26.481 57.304 -25.945 58.312 c -27.078 58.041 m -27.434 57.393 -28.252 56.506 -29.855 57.177 c -31.012 57.661 -31.85 58.634 -31.105 60.41 c -30.107 62.794 -28.324 62.153 -27.893 61.973 c -26.289 61.302 -26.301 60.131 -26.549 59.452 c -27.595 59.89 l -27.375 60.687 -27.963 60.971 -28.207 61.073 c -28.447 61.173 -29.306 61.479 -29.938 59.968 c -30.295 59.115 -30.165 58.339 -29.441 58.036 c -28.744 57.743 -28.324 58.168 -28.137 58.484 c h -39.891 63.516 m -40.08 62.582 l -42.072 62.986 l -42.445 61.147 l -43.576 61.377 l -42.602 66.182 l -39.115 65.474 l -39.305 64.54 l -41.659 65.019 l -41.883 63.92 l h -45.582 64.174 m -45.527 64.611 -45.426 65.807 -46.6 65.954 c -47.232 66.034 -47.858 65.767 -48.021 64.48 c -48.181 63.209 -47.643 62.781 -47.01 62.702 c -45.842 62.555 -45.633 63.764 -45.582 64.174 c -49.265 64.638 m -49.122 65.771 -48.398 67.141 -46.48 66.899 c -44.807 66.688 -44.159 65.491 -44.345 64.018 c -44.53 62.545 -45.454 61.546 -47.129 61.757 c -49.046 61.998 -49.407 63.505 -49.265 64.638 c -61.771 65.291 m -61.572 62.229 l -62.725 62.154 l -63.045 67.046 l -61.877 67.123 l -59.75 64.208 l -59.729 64.21 l -59.928 67.25 l -58.774 67.325 l -58.455 62.433 l -59.629 62.356 l -61.758 65.292 l h -65.403 64.294 m -65.468 64.731 -65.692 65.909 -66.863 65.735 c -67.493 65.642 -68.025 65.215 -67.835 63.934 c -67.646 62.666 -67.013 62.399 -66.382 62.493 c -65.219 62.665 -65.343 63.886 -65.403 64.294 c -69.075 63.75 m -69.243 64.879 -68.915 66.394 -67.003 66.677 c -65.333 66.925 -64.388 65.946 -64.17 64.477 c -63.952 63.008 -64.573 61.798 -66.242 61.55 c -68.155 61.267 -68.908 62.621 -69.075 63.75 c -70.839 65.862 m -69.823 61.066 l -70.953 60.827 l -71.97 65.623 l h -76.844 63.402 m -77.091 64.322 l -73.112 65.389 l -72.865 64.469 l -74.293 64.086 l -73.27 60.271 l -74.386 59.971 l -75.409 63.787 l h -77.927 60.725 m -79.127 62.292 l -79.133 60.313 l h -78.991 63.692 m -75.664 59.647 l -76.824 59.251 l -77.42 60.017 l -79.104 59.443 l -79.098 58.475 l -80.252 58.082 l -80.098 63.314 l h -82.818 62.295 m -80.961 57.758 l -82.03 57.32 l -83.888 61.857 l h -83.708 58.527 m -83.455 57.833 -83.329 56.632 -84.892 55.871 c -86.019 55.322 -87.303 55.335 -88.146 57.066 c -89.278 59.39 -87.621 60.307 -87.199 60.512 c -85.638 61.272 -84.766 60.489 -84.418 59.856 c -85.438 59.359 l -85.892 60.05 -86.492 59.797 -86.731 59.68 c -86.965 59.566 -87.762 59.124 -87.043 57.65 c -86.639 56.819 -85.97 56.405 -85.264 56.749 c -84.584 57.08 -84.625 57.675 -84.74 58.024 c h -90.203 55.988 m -90.434 56.365 -91.102 57.36 -92.11 56.742 c -92.654 56.41 -92.977 55.809 -92.3 54.704 c -91.631 53.611 -90.941 53.614 -90.398 53.947 c -89.395 54.562 -89.987 55.636 -90.203 55.988 c -93.369 54.049 m -93.965 55.023 -94.256 56.545 -92.607 57.555 c -91.168 58.437 -89.916 57.905 -89.141 56.639 c -88.365 55.373 -88.461 54.016 -89.9 53.134 c -91.549 52.125 -92.773 53.076 -93.369 54.049 c -96.106 50.94 m -95.931 50.696 -95.514 50.414 -94.855 50.913 c -94.51 51.174 -94.203 51.502 -94.462 51.843 c -94.783 52.267 -95.361 51.953 -95.916 51.699 c -96.738 51.322 -97.461 51.057 -98.119 51.928 c -98.598 52.559 -98.57 53.405 -97.393 54.297 c -96.31 55.117 -95.453 54.799 -95.012 54.239 c -95.883 53.579 l -96.065 53.774 -96.377 53.873 -96.873 53.496 c -97.332 53.149 -97.341 52.861 -97.193 52.666 c -96.936 52.325 -96.444 52.582 -96.059 52.768 c -95.119 53.234 -94.271 53.552 -93.624 52.697 c -93.383 52.379 -92.729 51.329 -94.291 50.145 c -95.732 49.054 -96.641 49.719 -97.039 50.234 c h -99.954 47.604 m -99.755 47.377 -99.313 47.137 -98.706 47.698 c -98.387 47.992 -98.115 48.348 -98.405 48.662 c -98.766 49.053 -99.312 48.684 -99.839 48.377 c -100.62 47.923 -101.313 47.588 -102.054 48.391 c -102.591 48.973 -102.646 49.818 -101.561 50.82 c -100.563 51.742 -99.679 51.508 -99.185 50.993 c -99.987 50.252 l -100.188 50.428 -100.507 50.496 -100.966 50.073 c -101.388 49.683 -101.37 49.395 -101.203 49.215 c -100.913 48.901 -100.45 49.205 -100.085 49.428 c -99.194 49.982 -98.381 50.381 -97.653 49.593 c -97.384 49.3 -96.63 48.318 -98.07 46.988 c -99.397 45.762 -100.366 46.336 -100.813 46.81 c h -102.542 45.161 m -104.363 45.921 l -103.383 44.203 l h -104.943 47.203 m -100.043 45.354 l -100.852 44.433 l -101.75 44.801 l -102.922 43.464 l -102.436 42.627 l -103.24 41.711 l -105.715 46.324 l h -111.779 32.964 m -108.961 31.755 l -109.416 30.692 l -113.922 32.625 l -113.461 33.7 l -109.898 34.275 l -109.891 34.294 l -112.69 35.495 l -112.235 36.558 l -107.729 34.625 l -108.193 33.544 l -111.774 32.977 l h -111.796 28.849 m -113.767 28.727 l -112.128 27.618 l h -114.853 29.622 m -109.639 30.124 l -109.958 28.94 l -110.926 28.875 l -111.39 27.157 l -110.584 26.621 l -110.901 25.444 l -115.157 28.493 l h -115.798 25.494 m -110.957 24.719 l -111.14 23.578 l -115.98 24.353 l h -113.075 19.626 m -112.774 19.604 -112.29 19.739 -112.246 20.565 c -112.224 20.998 -112.277 21.443 -112.704 21.466 c -113.235 21.494 -113.367 20.849 -113.532 20.261 c -113.774 19.39 -114.037 18.668 -115.128 18.726 c -115.919 18.769 -116.548 19.335 -116.47 20.811 c -116.397 22.167 -115.602 22.615 -114.888 22.592 c -114.946 21.5 l -115.214 21.487 -115.489 21.312 -115.522 20.69 c -115.553 20.116 -115.339 19.922 -115.094 19.91 c -114.667 19.887 -114.547 20.427 -114.44 20.842 c -114.19 21.86 -113.886 22.714 -112.815 22.657 c -112.417 22.636 -111.192 22.458 -111.296 20.5 c -111.393 18.696 -112.486 18.431 -113.137 18.459 c h -112.86 14.514 m -112.56 14.533 -112.099 14.734 -112.17 15.559 c -112.208 15.991 -112.322 16.424 -112.748 16.387 c -113.278 16.341 -113.32 15.684 -113.401 15.079 c -113.521 14.184 -113.68 13.432 -114.769 13.337 c -115.558 13.27 -116.26 13.743 -116.387 15.216 c -116.504 16.569 -115.778 17.123 -115.067 17.199 c -114.973 16.11 l -115.236 16.06 -115.485 15.849 -115.431 15.228 c -115.382 14.655 -115.144 14.493 -114.899 14.514 c -114.473 14.551 -114.429 15.104 -114.382 15.528 c -114.274 16.571 -114.092 17.459 -113.025 17.551 c -112.627 17.586 -111.389 17.58 -111.22 15.626 c -111.065 13.826 -112.111 13.412 -112.76 13.349 c h -115.092 8.454 m -112.311 9.11 l -111.521 9.298 -111.168 9.633 -111.334 10.335 c -111.497 11.023 -111.938 11.185 -112.755 10.992 c -115.537 10.335 l -115.802 11.46 l -112.838 12.16 l -112.353 12.274 -110.879 12.552 -110.407 10.554 c -109.933 8.542 -111.343 8.152 -111.862 8.029 c -114.827 7.329 l h -111.164 3.726 m -111.554 4.708 l -111.794 5.313 -112.18 5.259 -112.401 5.172 c -112.85 4.993 -112.88 4.672 -112.697 4.21 c -112.323 3.266 l h -112.782 1.841 m -113.707 4.171 l -113.89 4.633 -114.205 5.767 -113.026 6.234 c -112.258 6.539 -111.795 6.15 -111.572 5.893 c -111.559 5.897 l -111.627 6.601 -111.04 6.85 -110.71 6.987 c -110.136 7.23 -109.948 7.306 -109.778 7.562 c -109.344 6.468 l -109.553 6.158 -109.756 6.161 -110.43 5.825 c -110.958 5.563 -110.708 5.007 -110.659 4.883 c -110.331 4.057 l -108.651 4.723 l -108.225 3.649 l h -6.302 18.722 m -6.302 30.453 -12.869 40.976 -23.267 48.14 c -57.542 18.696 l -23.236 -10.677 l -12.856 -3.513 -6.302 7.001 -6.302 18.722 c -105.589 18.722 m -105.589 1.51 -91.455 -13.103 -71.825 -18.315 c -71.825 55.759 l -91.455 50.544 -105.589 35.933 -105.589 18.722 c -55.929 59.846 m -84.862 59.846 -108.401 41.348 -108.401 18.611 c -108.401 -4.124 -84.862 -22.621 -55.929 -22.621 c -26.996 -22.621 -3.458 -4.124 -3.458 18.611 c -3.458 41.348 -26.996 59.846 -55.929 59.846 c -55.929 -24.121 m -85.688 -24.121 -109.901 -4.951 -109.901 18.611 c -109.901 42.176 -85.688 61.346 -55.929 61.346 c -26.169 61.346 -1.958 42.176 -1.958 18.611 c -1.958 -4.951 -26.169 -24.121 -55.929 -24.121 c f Q EMC Q BT /T1_2 1 Tf 10 0 0 10 42.5197 400.8991 Tm [(EDIT)28(ORIAL OFFICE)]TJ 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0 -1.2 TD [(Salyama Adilya St., 2, Moscow)17.1(, R)21(ussia, 1)150(2)38(3)50(4)50(2)38(3)]TJ 0 -1.767 TD (Phone & fax:)Tj /Span<>> BDC [( )-244( )]TJ EMC 5.497 0 Td [(+7 \(4)25(99\) 64)50(2-5)25(4-4)100(1)75(, ext. 1)149.9(2-7)137.1(1)]TJ 0 Tw ( )Tj 0.023 Tw 0 -1.2 TD [(+7 \(4)25(99\) 1)112(99-00-68)]TJ 0 Tw -5.497 -1.767 Td (E-mail:\016)Tj /Span<>> BDC 2.913 0 Td ( )Tj EMC /T1_2 1 Tf 0 0 TD [(pr)10(oc)-10(tologia@mail.ru)]TJ ( )Tj 0 -1.2 TD [(k)21(olopr)10(oktologia@akr)-61.8(-online)-31(.ru)]TJ /T1_1 1 Tf 0.01 Tc -0.01 Tw -2.913 -1.767 Td [(h)-0.9(t)-22.1(t)-5.8(p)6.1(s)9.4(:)40.1(/)213.5(/)133.2(do)1.8(i)4.8(.)18.8(or)7.4(g)9.5(/)95.2(1)58.6(0)16.8(.3)21.9(3)22.7(8)31.4(7)38.7(8)70.6(/)69.5(2)18.1(0)29.5(7)28(3)-7.9(-)20.1(7)59.9(5)21.7(5)18.8(6)]TJ 0 -2.05 TD [(h)-0.9(t)-22.1(t)-5.8(p)25.4(:)40.1(/)213.5(/)79.1(w)-31.3(w)-31.3(w)60(.)3.9(r)-9.1(u)1.6(pr)8.8(oc)-15(t)-1.8(o)-0.7(log)-3.7(y)64.7(.)16.4(c)-3.4(om)]TJ /T1_0 1 Tf 0.006 Tc -0.006 Tw 0 -1.767 TD [(h)-1(t)-29.3(t)-9(p)22.1(:)29.3(/)172.7(/)48.3(w)-35.6(w)-35.5(w)49.8(.)12.6(ak)-7.5(r)31.8(-)-19.1(o)-2.1(n)0.6(lin)-1.7(e)6.1(.)2(r)-10.4(u)]TJ 0 Tc 0 Tw 9.939 0 Td ( )Tj -0.044 Tc 0.044 Tw -9.939 -1.2 Td [(h)-51(t)-79.3(t)-59(p)-27.9(:)-20.7(/)122.7(/)-1.7(w)-85.6(w)-85.6(w.)-48(n)-51.7(e)-40.6(w.)-37.3(g)-50.5(n)-50.1(c)-56.7(k)-61.2(.)-48(r)-60.4(u)]TJ 0 Tc 0.023 Tw 26.362 13.918 Td [(T)72(he journal is r)24(egister)24(ed by the F)42(eder)21.1(al Ser)-21(vice for )]TJ 0 -1.2 TD [(Super)-20.9(vision of Communications, Information T)84.1(echnology )]TJ T* (and Mass Media.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0 -1.767 TD [(Cer)-31(tificate of r)21.1(egistr)10(ation PI )]TJ 0 Tw ( )Tj 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0 -1.2 TD [(no.\016)-23.2(7)12.9(7-1)125.1(409)37(7)]TJ /T1_2 1 Tf 0.023 Tw 0 -1.767 TD [(Subscription inde)21(x: )]TJ 0 Tw ( )Tj 0.023 Tw 0 -1.2 TD [(\037\004 \253P)10(ochta Ro)21(s)20(sii\273\026)-23.3(\227 PP7)80(1)104(5)]TJ 0 Tw ( )Tj 0.023 Tw T* [(\004\004\004 \253Ur)10(al-Pr)21(es)20(s Okrug)]TJ 0 Tw (\273)Tj 0.023 Tw [(\026)-23.3(\227 809)23(7)34(8)]TJ 0 -1.767 TD [(T)42(h)11(e journal is pr)21(esented in th)11(e follo)21.1(wing r)21(ese)-9.9(ar)11(ch )]TJ 0 Tw 0 -1.2 TD (databases:)Tj /T1_0 1 Tf -0.233 Tw T* (\227)Tj /Span<>> BDC [( )-500( )]TJ EMC (SCOPUS)Tj 0.023 Tw T* (\227)Tj /Span<>> BDC [( )-244( )]TJ EMC 1.3 0 Td [(R)21(ussian Science Citation Index \(RSCI\), integr)21(ated in )]TJ T* [(W)41(eb of Science)]TJ -1.3 -1.767 Td [(W)59(hen placing ads, the editorial Boar)24(d of the journal is )]TJ T* [(guided by the adver)-20(tising policy)]TJ 9 0 0 9 306.1418 134.4424 Tm [(Signed to the pr)24.1(ess on 1)137(3.02.2)25.1(02)50(4)]TJ 0 Tw ( )Tj 0.023 Tw 0 -1.333 TD [(Cir)24(culation 1)63(000 copies)]TJ 0 Tw ( )Tj 0.023 Tw 0 -1.333 TD [(Printed by I.A.\016)-23.2(Er)11(shov )]TJ 0 -1.963 TD [(Information about the cost of a copy\016)-23.3(\227 fr)24(ee price)]TJ 1 0.68 0 0.12 k /GS0 gs 0.01 Tc -0.005 Tw 13.3 0 0 14 145.6464 485.8571 Tm [(RUS)21(SIAN)5( A)11(S)21(SOCIA)42(TION)5( OF)5( COL)34(OPROCT)35(OL)34.1(OGY)]TJ 0 0 0 1 k /GS1 gs 0 Tc 0.023 Tw 12 0 0 12 242.0093 469.0225 Tm [(IS)21(SN 2)25(0)50(7)75(3-7)88.1(556)]TJ 0 Tw ( )Tj 0.023 Tw -1.79 -1.167 Td [(Quar)-19.9(terly since 2)25(002 year)]TJ 8 0 0 8 42.5197 59.6851 Tm (\251)Tj /Span<>> BDC [( )-244( )]TJ EMC 1.24 0 Td [(RUS)21(SIAN A)10.9(S)21(SOCIA)42.1(TION OF COL)34(OPROCT)35(OL)34(OGY)62(, 2)25(02)50(4)]TJ ET 0 0 0 0 k /GS0 gs 42.52 44.015 60.343 11.34 re f /PlacedPDF /MC1 BDC 0 0 0 1 k 42.534 44.03 60.328 11.326 re 42.534 55.355 m 43.306 54.57 58.771 -9.769 re f q 42.52 44.015 60.343 11.34 re W n q 1 0 0 1 59.1907 53.9074 cm 0 0 m 0.962 -1.226 1.608 -2.673 1.608 -4.222 c 1.608 -5.781 0.951 -7.212 -0.023 -8.443 c 42.162 -8.443 l 42.162 0 l 0 0 l f Q 0 0 0 0.4 k q 1 0 0 1 46.2629 49.695 cm 0 0 m 0 1.495 0.569 2.789 1.707 3.882 c 1.83 4 1.957 4.108 2.086 4.212 c -2.233 4.212 l -2.233 -4.231 l 2.141 -4.231 l 1.992 -4.114 1.848 -3.989 1.707 -3.855 c 0.569 -2.78 0 -1.495 0 0 c f Q 0 0 0 1 k q 1 0 0 1 52.5767 50.9245 cm 0 0 m 0.317 0.306 0.72 0.458 1.21 0.458 c 1.921 0.458 2.431 0.193 2.738 -0.337 c 1.958 -0.707 l 1.813 -0.409 1.602 -0.26 1.322 -0.26 c 0.802 -0.26 0.542 -0.584 0.542 -1.233 c 0.542 -1.882 0.802 -2.207 1.322 -2.207 c 1.659 -2.207 1.896 -2.048 2.03 -1.732 c 2.753 -2.088 l 2.417 -2.653 1.912 -2.937 1.239 -2.937 c 0.72 -2.937 0.305 -2.786 -0.008 -2.485 c -0.32 -2.184 -0.476 -1.768 -0.476 -1.239 c -0.476 -0.719 -0.317 -0.306 0 0 c f Q q 1 0 0 1 51.9748 50.5876 cm 0 0 m -0.765 -0.37 l -0.909 -0.072 -1.125 0.077 -1.414 0.077 c -1.924 0.077 -2.179 -0.248 -2.179 -0.896 c -2.179 -1.545 -1.924 -1.87 -1.414 -1.87 c -1.077 -1.87 -0.837 -1.711 -0.692 -1.395 c 0.014 -1.751 l -0.323 -2.316 -0.828 -2.6 -1.502 -2.6 c -2.021 -2.6 -2.438 -2.449 -2.75 -2.148 c -3.064 -1.847 -3.22 -1.431 -3.22 -0.902 c -3.22 -0.382 -3.059 0.031 -2.736 0.337 c -2.414 0.643 -2.012 0.795 -1.531 0.795 c -0.818 0.795 -0.308 0.53 0 0 c f Q q 1 0 0 1 56.1397 53.5768 cm 0 0 m -0.125 0.118 -0.253 0.226 -0.383 0.331 c -1.737 0.331 l -0.144 -0.47 0.942 -2.052 0.943 -3.876 c 0.943 -3.882 l 0.945 -5.723 -0.161 -7.318 -1.777 -8.113 c -0.43 -8.113 l -0.273 -7.992 -0.121 -7.863 0.029 -7.723 c 1.128 -6.694 1.677 -5.413 1.677 -3.882 c 1.677 -2.351 1.118 -1.057 0 0 c f Q q 1 0 0 1 46.9972 49.6891 cm 0 0 m 0 0.006 l -0.001 1.832 1.085 3.417 2.681 4.218 c 1.352 4.218 l 1.223 4.114 1.095 4.005 0.972 3.888 c -0.166 2.794 -0.734 1.5 -0.734 0.006 c -0.734 -1.489 -0.166 -2.774 0.972 -3.849 c 1.113 -3.983 1.258 -4.108 1.406 -4.225 c 2.72 -4.225 l 1.105 -3.431 0.001 -1.839 0 0 c f Q 0 0 0 0.4 k q 1 0 0 1 59.1907 53.9074 cm 0 0 m -3.435 0 l -3.305 -0.104 -3.176 -0.213 -3.052 -0.33 c -1.934 -1.387 -1.375 -2.682 -1.375 -4.212 c -1.375 -5.744 -1.924 -7.023 -3.023 -8.054 c -3.172 -8.193 -3.325 -8.322 -3.481 -8.443 c -0.023 -8.443 l 0.951 -7.212 1.608 -5.781 1.608 -4.222 c 1.608 -2.673 0.962 -1.226 0 0 c f Q 0 0 0 0 k q 1 0 0 1 66.2517 51.7951 cm 0 0 m 1.271 0 l 2.298 -1.508 l 3.324 0 l 4.599 0 l 2.881 -2.45 l 2.881 -4.232 l 1.718 -4.232 l 1.718 -2.45 l 0 0 l -0.685 -1.967 m -0.436 -2.035 -0.241 -2.161 -0.104 -2.344 c 0.032 -2.528 0.101 -2.752 0.101 -3.02 c 0.101 -3.427 -0.047 -3.731 -0.341 -3.932 c -0.634 -4.133 -1.081 -4.232 -1.682 -4.232 c -3.611 -4.232 l -3.611 0 l -1.865 0 l -1.239 0 -0.786 -0.088 -0.506 -0.267 c -0.225 -0.443 -0.084 -0.729 -0.084 -1.119 c -0.084 -1.326 -0.135 -1.501 -0.237 -1.647 c -0.341 -1.791 -0.489 -1.898 -0.685 -1.967 c -1.766 -3.49 m -1.532 -3.49 -1.357 -3.443 -1.24 -3.351 c -1.121 -3.259 -1.062 -3.119 -1.062 -2.931 c -1.062 -2.748 -1.121 -2.61 -1.237 -2.521 c -1.354 -2.428 -1.53 -2.381 -1.766 -2.381 c -2.449 -2.381 l -2.449 -3.49 l -1.766 -3.49 l -1.806 -1.639 m -1.622 -1.639 -1.482 -1.601 -1.389 -1.525 c -1.294 -1.45 -1.246 -1.338 -1.246 -1.19 c -1.246 -1.045 -1.294 -0.934 -1.389 -0.858 c -1.482 -0.781 -1.622 -0.742 -1.806 -0.742 c -2.449 -0.742 l -2.449 -1.639 l -1.806 -1.639 l f Q q 1 0 0 1 75.8057 49.2809 cm 0 0 m 0 0.951 l 0 1.209 0.014 1.473 0.033 1.751 c 0.007 1.751 l -0.132 1.473 -0.244 1.222 -0.39 0.951 c -0.965 0.013 l -0.965 0 l h 0 -1.777 m 0 -0.753 l -1.902 -0.753 l -1.902 -0.099 l -0.277 2.517 l 0.951 2.517 l 0.951 0 l 1.467 0 l 1.467 -0.753 l 0.951 -0.753 l 0.951 -1.777 l 0 -1.777 l f Q q 1 0 0 1 77.7467 48.0387 cm 0 0 m 0 0.357 0.245 0.614 0.595 0.614 c 0.945 0.614 1.183 0.363 1.183 0 c 1.183 -0.35 0.945 -0.608 0.588 -0.608 c 0.245 -0.608 0 -0.35 0 0 c f Q q 1 0 0 1 80.3567 49.6442 cm 0 0 m -0.007 -0.984 0.229 -1.454 0.621 -1.454 c 1.011 -1.454 1.222 -0.964 1.222 0.013 c 1.222 0.965 1.018 1.467 0.614 1.467 c 0.244 1.467 -0.007 0.998 0 0 c 2.227 0.026 m 2.227 -1.302 1.69 -2.213 0.595 -2.213 c -0.517 -2.213 -1.005 -1.216 -1.012 0 c -1.012 1.242 -0.482 2.227 0.627 2.227 c 1.777 2.227 2.227 1.203 2.227 0.026 c f Q EMC Q BT /GS1 gs /T1_0 1 Tf 6 0 0 6 42.5197 34.0158 Tm [(T)-29.9(h)-22.8(i)-20.4(s w)-13.1(o)-25.6(r)-33.3(k i)-20.4(s l)-23.5(i)-21.7(c)-25.2(e)-25.2(n)-19.9(s)-29.7(e)-26.6(d u)-22.9(n)-25.2(d)-26.9(e)-25.2(r a C)-24.5(r)-17.1(e)-26.6(a)-29.9(t)-32(i)-27.9(v)-13.5(e C)-24.5(o)-25.7(m)-23.7(m)-24.3(o)-25.7(n)-20(s A)-32.6(t)-50.9(t)-32(r)-33.4(i)-23.4(b)-24.3(u)-26.2(t)-32(i)-21.7(o)-25.6(n 4)-29.5(.)-12.4(0 L)-30(i)-21.7(c)-25.2(e)-25.2(n)-19.9(s)-29.7(e)-18.4(.)]TJ ET /GS0 gs q 1 0 0 1 283.4646 408.189 cm 0 0 m 0 -317.48 l S Q endstream endobj 2733 0 obj <> endobj 2734 0 obj <> endobj 2740 0 obj <>stream Adobe Graphics Manager 2021-04-12T11:52:16+05:00 2021-04-12T11:52:16+05:00 Acrobat Distiller 10.1.16 (Windows) CCBYv40_logo.ai densen endstream endobj 2739 0 obj <>stream Adobe Illustrator CS6 (Windows) 2021-03-20T11:35:37+06:00 2021-03-20T11:35:37+05:00 2021-03-20T11:35:37+05:00 1 False True 44.283602 32.991785 Millimeters Cyan Magenta Black Default Swatch Group 0 C=100 M=68 Y=0 K=12 PROCESS 100.000000 CMYK 100.000000 68.000000 0.000000 12.000000 application/pdf logo_eng xmp.did:562411794689EB119856D7C1468A9BFF uuid:365aeb11-afd7-44f1-b90e-54e177120fce xmp.did:877d3e89-8f6e-3147-a3da-4e72d0a73d9c proof:pdf converted from application/postscript to application/vnd.adobe.illustrator saved xmp.iid:877d3e89-8f6e-3147-a3da-4e72d0a73d9c 2019-04-10T11:26:07+03:00 Adobe Illustrator CC 2015 (Windows) / saved xmp.iid:562411794689EB119856D7C1468A9BFF 2021-03-20T11:35:33+05:00 Adobe Illustrator CS6 (Windows) / uuid:98de7be3-c311-46e2-b8c8-c50daf15aed4 xmp.did:eaa18b5d-27cd-f940-b644-f62b4d0bb73d xmp.did:877d3e89-8f6e-3147-a3da-4e72d0a73d9c proof:pdf Document Adobe PDF library 10.01 endstream endobj 2729 0 obj <>stream BT 0 0 0 1 k /GS0 gs /T1_0 1 Tf 0.023 Tw 8 0 0 8 42.5197 59.685 Tm (\251)Tj /Span<>> BDC [( )-244( )]TJ EMC 1.24 0 Td [(\037\036\035\034\033\037\032\032\031\030\032\027\026\025 \037\036\035\034\ \032\024\023\034\022\022\026\025 \037\033\021)80(\026\022\031\020)21(\026\017\031\025 \253\026)21.1(\032\032\037\017\031\026\017\031\025\016)-23.3(\027)42(\037\r\037\f\033\037\027)10.1(\024)35(\037\r\037\021)35(\037\023 \033\037\032\032\031\031\273, 2)25(02)50(4)]TJ ET 0 0 0 0 k /GS1 gs 42.52 44.015 60.343 11.34 re f /PlacedPDF /MC0 BDC 0 0 0 1 k 42.534 44.03 60.328 11.326 re 42.534 55.355 m 43.306 54.57 58.771 -9.769 re f q 42.52 44.015 60.343 11.34 re W n q 1 0 0 1 59.1907 53.9073 cm 0 0 m 0.962 -1.226 1.608 -2.673 1.608 -4.222 c 1.608 -5.781 0.951 -7.212 -0.023 -8.443 c 42.162 -8.443 l 42.162 0 l 0 0 l f Q 0 0 0 0.4 k q 1 0 0 1 46.2629 49.6949 cm 0 0 m 0 1.495 0.569 2.789 1.707 3.882 c 1.83 4 1.957 4.108 2.086 4.212 c -2.233 4.212 l -2.233 -4.231 l 2.141 -4.231 l 1.992 -4.114 1.848 -3.989 1.707 -3.855 c 0.569 -2.78 0 -1.495 0 0 c f Q 0 0 0 1 k q 1 0 0 1 52.5767 50.9245 cm 0 0 m 0.317 0.306 0.72 0.458 1.21 0.458 c 1.921 0.458 2.431 0.193 2.738 -0.337 c 1.958 -0.707 l 1.813 -0.409 1.602 -0.26 1.322 -0.26 c 0.802 -0.26 0.542 -0.584 0.542 -1.233 c 0.542 -1.882 0.802 -2.207 1.322 -2.207 c 1.659 -2.207 1.896 -2.048 2.03 -1.732 c 2.753 -2.088 l 2.417 -2.653 1.912 -2.937 1.239 -2.937 c 0.72 -2.937 0.305 -2.786 -0.008 -2.485 c -0.32 -2.184 -0.476 -1.768 -0.476 -1.239 c -0.476 -0.719 -0.317 -0.306 0 0 c f Q q 1 0 0 1 51.9748 50.5876 cm 0 0 m -0.765 -0.37 l -0.909 -0.072 -1.125 0.077 -1.414 0.077 c -1.924 0.077 -2.179 -0.248 -2.179 -0.896 c -2.179 -1.545 -1.924 -1.87 -1.414 -1.87 c -1.077 -1.87 -0.837 -1.711 -0.692 -1.395 c 0.014 -1.751 l -0.323 -2.316 -0.828 -2.6 -1.502 -2.6 c -2.021 -2.6 -2.438 -2.449 -2.75 -2.148 c -3.064 -1.847 -3.22 -1.431 -3.22 -0.902 c -3.22 -0.382 -3.059 0.031 -2.736 0.337 c -2.414 0.643 -2.012 0.795 -1.531 0.795 c -0.818 0.795 -0.308 0.53 0 0 c f Q q 1 0 0 1 56.1397 53.5768 cm 0 0 m -0.125 0.118 -0.253 0.226 -0.383 0.331 c -1.737 0.331 l -0.144 -0.47 0.942 -2.052 0.943 -3.876 c 0.943 -3.882 l 0.945 -5.723 -0.161 -7.318 -1.777 -8.113 c -0.43 -8.113 l -0.273 -7.992 -0.121 -7.863 0.029 -7.723 c 1.128 -6.694 1.677 -5.413 1.677 -3.882 c 1.677 -2.351 1.118 -1.057 0 0 c f Q q 1 0 0 1 46.9972 49.6891 cm 0 0 m 0 0.006 l -0.001 1.832 1.085 3.417 2.681 4.218 c 1.352 4.218 l 1.223 4.114 1.095 4.005 0.972 3.888 c -0.166 2.794 -0.734 1.5 -0.734 0.006 c -0.734 -1.489 -0.166 -2.774 0.972 -3.849 c 1.113 -3.983 1.258 -4.108 1.406 -4.225 c 2.72 -4.225 l 1.105 -3.431 0.001 -1.839 0 0 c f Q 0 0 0 0.4 k q 1 0 0 1 59.1907 53.9073 cm 0 0 m -3.435 0 l -3.305 -0.104 -3.176 -0.213 -3.052 -0.33 c -1.934 -1.387 -1.375 -2.682 -1.375 -4.212 c -1.375 -5.744 -1.924 -7.023 -3.023 -8.054 c -3.172 -8.193 -3.325 -8.322 -3.481 -8.443 c -0.023 -8.443 l 0.951 -7.212 1.608 -5.781 1.608 -4.222 c 1.608 -2.673 0.962 -1.226 0 0 c f Q 0 0 0 0 k q 1 0 0 1 66.2517 51.795 cm 0 0 m 1.271 0 l 2.298 -1.508 l 3.324 0 l 4.599 0 l 2.881 -2.45 l 2.881 -4.232 l 1.718 -4.232 l 1.718 -2.45 l 0 0 l -0.685 -1.967 m -0.436 -2.035 -0.241 -2.161 -0.104 -2.344 c 0.032 -2.528 0.101 -2.752 0.101 -3.02 c 0.101 -3.427 -0.047 -3.731 -0.341 -3.932 c -0.634 -4.133 -1.081 -4.232 -1.682 -4.232 c -3.611 -4.232 l -3.611 0 l -1.865 0 l -1.239 0 -0.786 -0.088 -0.506 -0.267 c -0.225 -0.443 -0.084 -0.729 -0.084 -1.119 c -0.084 -1.326 -0.135 -1.501 -0.237 -1.647 c -0.341 -1.791 -0.489 -1.898 -0.685 -1.967 c -1.766 -3.49 m -1.532 -3.49 -1.357 -3.443 -1.24 -3.351 c -1.121 -3.259 -1.062 -3.119 -1.062 -2.931 c -1.062 -2.748 -1.121 -2.61 -1.237 -2.521 c -1.354 -2.428 -1.53 -2.381 -1.766 -2.381 c -2.449 -2.381 l -2.449 -3.49 l -1.766 -3.49 l -1.806 -1.639 m -1.622 -1.639 -1.482 -1.601 -1.389 -1.525 c -1.294 -1.45 -1.246 -1.338 -1.246 -1.19 c -1.246 -1.045 -1.294 -0.934 -1.389 -0.858 c -1.482 -0.781 -1.622 -0.742 -1.806 -0.742 c -2.449 -0.742 l -2.449 -1.639 l -1.806 -1.639 l f Q q 1 0 0 1 75.8057 49.2809 cm 0 0 m 0 0.951 l 0 1.209 0.014 1.473 0.033 1.751 c 0.007 1.751 l -0.132 1.473 -0.244 1.222 -0.39 0.951 c -0.965 0.013 l -0.965 0 l h 0 -1.777 m 0 -0.753 l -1.902 -0.753 l -1.902 -0.099 l -0.277 2.517 l 0.951 2.517 l 0.951 0 l 1.467 0 l 1.467 -0.753 l 0.951 -0.753 l 0.951 -1.777 l 0 -1.777 l f Q q 1 0 0 1 77.7467 48.0387 cm 0 0 m 0 0.357 0.245 0.614 0.595 0.614 c 0.945 0.614 1.183 0.363 1.183 0 c 1.183 -0.35 0.945 -0.608 0.588 -0.608 c 0.245 -0.608 0 -0.35 0 0 c f Q q 1 0 0 1 80.3567 49.6441 cm 0 0 m -0.007 -0.984 0.229 -1.454 0.621 -1.454 c 1.011 -1.454 1.222 -0.964 1.222 0.013 c 1.222 0.965 1.018 1.467 0.614 1.467 c 0.244 1.467 -0.007 0.998 0 0 c 2.227 0.026 m 2.227 -1.302 1.69 -2.213 0.595 -2.213 c -0.517 -2.213 -1.005 -1.216 -1.012 0 c -1.012 1.242 -0.482 2.227 0.627 2.227 c 1.777 2.227 2.227 1.203 2.227 0.026 c f Q EMC Q BT /GS0 gs /T1_0 1 Tf 0.033 Tc -0.01 Tw 6 0 0 6 42.5197 34.0157 Tm [(\027)27.6(\013)1.1(\n)-3.4(\t)1.1(\b\n)-3.4(\t)33( \007)-2.1(\013\006)-13.7(\t)-30.4(\005)-3.9(\004\b\n)33( \004)1.6(\013\007)33( \003)1.8(\002)1.5(\001)-2.2(\b\n)11.9()1.6(\002\b)1.7(\201)33( C)8.5(r)15.9(e)6.4(a)3(t)1(i)5.2(v)19.5(e)33( C)8.5(o)7.3(m)9.3(m)8.7(o)7.3(n)13.1(s)33( At)-17.9(t)1.1(ri)9.6(b)8.7(u)6.8(t)1(i)11.3(o)7.4(n)33( 4)3.5(.)20.6(0)33( L)3(i)11.3(c)7.8(e)7.8(n)13(s)3.4(e)14.6(.)]TJ ET /PlacedPDF /MC1 BDC q 226.771 628.157 113.386 84.474 re W n q 1 0 0 1 330.9327 651.9356 cm 0 0 m -0.6 -1.027 l 1.562 -4.862 l 1.555 -4.875 l -1.728 -2.957 l -2.296 -3.931 l 2.552 -6.762 l 3.151 -5.736 l 0.97 -1.89 l 0.978 -1.875 l 4.28 -3.805 l 4.848 -2.832 l h 2.051 5.013 m 1.617 3.908 l 4.338 0.446 l 4.333 0.433 l 0.797 1.826 l 0.384 0.778 l 5.608 -1.281 l 6.044 -0.174 l 3.299 3.293 l 3.304 3.308 l 6.864 1.907 l 7.277 2.955 l h 6.183 5.938 m 5.934 4.792 l 6.666 4.689 8.008 4.984 8.395 6.773 c 8.665 8.027 8.076 9.45 6.049 9.886 c 4.3 10.264 2.972 9.599 2.62 7.97 c 2.37 6.808 2.814 5.719 4.13 5.179 c 4.377 6.319 l 4.053 6.494 3.414 6.838 3.625 7.802 c 3.805 8.635 4.617 8.996 5.803 8.741 c 7.438 8.387 7.493 7.408 7.4 6.988 c 7.188 6.001 6.523 5.961 6.183 5.938 c 7.179 11.876 m 7.127 10.704 l 7.863 10.725 9.139 11.239 9.222 13.069 c 9.279 14.349 8.461 15.654 6.39 15.748 c 4.602 15.829 3.404 14.951 3.329 13.286 c 3.275 12.098 3.895 11.098 5.283 10.786 c 5.335 11.95 l 4.988 12.069 4.302 12.302 4.347 13.286 c 4.384 14.139 5.128 14.629 6.338 14.576 c 8.009 14.501 8.225 13.543 8.207 13.114 c 8.16 12.106 7.512 11.954 7.179 11.876 c 5.678 22.028 m 4.018 21.811 2.869 20.764 3.1 18.972 c 3.315 17.32 4.712 16.46 6.372 16.675 c 8.031 16.89 9.164 18.078 8.949 19.73 c 8.717 21.522 7.338 22.242 5.678 22.028 c 4.109 19.103 m 3.986 20.049 4.72 20.719 5.828 20.864 c 6.938 21.007 7.818 20.546 7.942 19.6 c 8.063 18.653 7.33 17.982 6.222 17.839 c 5.112 17.695 4.233 18.157 4.109 19.103 c 1.531 26.144 m 1.872 25.022 l 3.805 25.609 l 4.178 24.381 l 4.513 23.274 5.435 22.826 6.438 23.131 c 7.514 23.458 7.992 24.2 7.647 25.338 c 6.905 27.777 l 1.531 26.144 l 6.317 26.373 m 6.642 25.31 l 6.795 24.801 6.656 24.424 6.096 24.253 c 5.535 24.083 5.21 24.32 5.056 24.828 c 4.731 25.89 l h -1.228 39.857 m -0.312 38.699 l -0.054 38.374 0.057 38.032 -0.317 37.736 c -0.678 37.45 -1.052 37.632 -1.305 37.951 c -2.203 39.085 l -1.228 39.857 l -5.57 37.855 m -3.972 35.837 l -3.185 34.845 -2.208 34.57 -1.359 35.246 c -0.985 35.542 -0.596 35.998 -0.842 36.762 c -0.34 36.53 0.046 36.586 0.485 36.937 c 0.953 37.305 1.396 38.106 0.541 39.184 c -1.169 41.343 l h -2.927 38.513 m -2.039 37.39 l -1.873 37.182 -1.485 36.64 -1.987 36.243 c -2.582 35.771 -2.989 36.158 -3.204 36.428 c -4.111 37.574 l h -8.02 44.223 m -9.18 43.018 -9.422 41.48 -8.12 40.228 c -6.92 39.072 -5.293 39.274 -4.132 40.48 c -2.97 41.686 -2.831 43.32 -4.031 44.475 c -5.332 45.729 -6.859 45.429 -8.02 44.223 c -7.415 40.961 m -8.103 41.623 -7.951 42.605 -7.175 43.409 c -6.398 44.216 -5.424 44.406 -4.735 43.745 c -4.048 43.081 -4.202 42.1 -4.978 41.294 c -5.752 40.489 -6.728 40.298 -7.415 40.961 c -13.405 44.813 m -12.473 44.1 l -9.653 47.792 l -7.396 46.069 l -6.807 46.84 l -9.996 49.275 l h -17.213 50.522 m -18.083 49.092 -17.984 47.539 -16.44 46.601 c -15.016 45.734 -13.471 46.287 -12.602 47.717 c -11.732 49.146 -11.95 50.772 -13.374 51.637 c -14.918 52.578 -16.343 51.952 -17.213 50.522 c -15.912 47.47 m -16.727 47.966 -16.792 48.957 -16.209 49.913 c -15.629 50.867 -14.717 51.265 -13.902 50.77 c -13.088 50.274 -13.022 49.282 -13.604 48.326 c -14.185 47.37 -15.096 46.973 -15.912 47.47 c -18.414 53.152 m -20.393 48.949 l -19.331 48.449 l -16.94 53.53 l -20.364 55.142 l -20.906 54.101 -21.42 53.045 -22.117 51.749 c -22.277 51.444 -22.537 50.875 -22.983 51.084 c -23.154 51.165 -23.29 51.333 -23.351 51.422 c -23.767 50.538 l -23.575 50.361 -23.396 50.206 -23.164 50.097 c -21.967 49.534 -21.431 50.544 -20.483 52.414 c -19.779 53.795 l -18.414 53.152 l -28.282 55.131 m -28.841 53.553 -28.424 52.055 -26.72 51.453 c -25.15 50.898 -23.752 51.757 -23.194 53.335 c -22.637 54.912 -23.185 56.459 -24.756 57.014 c -26.46 57.615 -27.725 56.71 -28.282 55.131 c -26.381 52.411 m -27.281 52.728 -27.549 53.686 -27.177 54.741 c -26.805 55.795 -25.994 56.372 -25.095 56.054 c -24.195 55.737 -23.928 54.78 -24.3 53.726 c -24.672 52.671 -25.481 52.094 -26.381 52.411 c -32.82 58.195 m -31.16 57.771 l -32.312 53.269 l -31.176 52.979 l -30.024 57.48 l -28.365 57.055 l -28.125 57.995 l -32.579 59.134 l h -38.871 54.545 m -37.716 54.347 l -37.4 56.206 l -36.749 56.682 l -35.448 53.964 l -33.96 53.711 l -35.797 57.387 l -33.137 59.268 l -34.634 59.522 l -37.161 57.618 l -36.778 59.884 l -37.933 60.081 l h -44.875 57.89 m -45.005 56.221 -44.216 54.881 -42.413 54.74 c -40.754 54.611 -39.625 55.801 -39.495 57.47 c -39.364 59.138 -40.293 60.49 -41.954 60.619 c -43.755 60.76 -44.744 59.559 -44.875 57.89 c -42.335 55.753 m -43.287 55.828 -43.792 56.684 -43.706 57.799 c -43.617 58.913 -42.986 59.68 -42.035 59.606 c -41.083 59.532 -40.578 58.676 -40.664 57.561 c -40.752 56.446 -41.383 55.679 -42.335 55.753 c -49.887 55.063 m -48.714 55.071 l -48.727 57.089 l -47.443 57.097 l -46.286 57.105 -45.595 57.86 -45.602 58.908 c -45.609 60.034 -46.186 60.703 -47.375 60.694 c -49.924 60.678 l -49.887 55.063 l -48.743 59.716 m -47.633 59.724 l -47.102 59.728 -46.779 59.486 -46.775 58.901 c -46.771 58.314 -47.091 58.069 -47.623 58.066 c -48.733 58.058 l h -55.483 54.626 m -54.315 54.729 l -54.722 59.357 l -52.526 59.551 l -52.117 54.923 l -50.949 55.025 l -51.442 60.619 l -55.977 60.219 l h -62.041 56.353 m -61.744 54.705 -60.641 53.609 -58.862 53.93 c -57.223 54.225 -56.434 55.663 -56.73 57.31 c -57.027 58.957 -58.269 60.029 -59.909 59.733 c -61.686 59.414 -62.338 58 -62.041 56.353 c -59.043 54.931 m -59.983 54.761 -60.688 55.461 -60.887 56.561 c -61.084 57.662 -60.667 58.563 -59.727 58.732 c -58.788 58.901 -58.083 58.203 -57.883 57.102 c -57.687 56.001 -58.104 55.1 -59.043 54.931 c -64.645 57.566 m -63.4 53.091 l -62.27 53.404 l -63.775 58.815 l -67.423 57.799 l -67.153 56.657 -66.853 55.522 -66.535 54.084 c -66.457 53.749 -66.281 53.148 -66.756 53.017 c -66.937 52.966 -67.151 53.004 -67.256 53.031 c -66.994 52.089 l -66.732 52.082 -66.496 52.082 -66.248 52.151 c -64.975 52.506 -65.228 53.621 -65.73 55.657 c -66.1 57.161 l -64.645 57.566 l -73.413 52.646 m -72.81 51.084 -71.518 50.217 -69.835 50.868 c -68.279 51.467 -67.777 53.029 -68.379 54.591 c -68.983 56.152 -70.405 56.969 -71.959 56.37 c -73.644 55.717 -74.016 54.207 -73.413 52.646 c -70.2 51.817 m -71.091 51.473 -71.916 52.026 -72.319 53.068 c -72.721 54.112 -72.483 55.077 -71.592 55.419 c -70.702 55.764 -69.876 55.212 -69.474 54.168 c -69.07 53.124 -69.31 52.16 -70.2 51.817 c -77.041 47.686 m -75.994 48.218 l -76.85 49.899 l -76.61 50.67 l -73.944 49.263 l -72.6 49.946 l -76.266 51.803 l -75.252 54.898 l -76.605 54.21 l -77.499 51.174 l -78.542 53.223 l -79.587 52.691 l h -88.633 46.447 m -90.497 44.706 l -91.424 43.841 -91.618 42.847 -90.875 42.052 c -89.995 41.11 -89.069 41.642 -88.832 41.778 c -88.475 38.91 l -87.418 39.898 l -87.802 42.578 l -87.151 43.187 l -85.636 41.563 l -84.801 42.343 l -88.633 46.447 l -87.771 43.872 m -88.799 42.912 l -88.993 42.729 -89.5 42.298 -89.932 42.762 c -90.451 43.315 -90.098 43.752 -89.847 43.987 c -88.795 44.969 l h -91.655 35.077 m -90.896 35.992 l -92.406 40.128 l -92.396 40.14 l -89.469 37.715 l -88.751 38.582 l -93.074 42.165 l -93.834 41.25 l -92.305 37.099 l -92.314 37.086 l -95.261 39.527 l -95.979 38.66 l h -94.564 30.485 m -92.462 33.893 l -91.543 33.5 l -91.01 34.366 l -92.755 35.268 l -93.001 34.869 l -96.955 37.307 l -97.572 36.308 l -93.618 33.87 l -94.774 31.993 l -98.728 34.431 l -99.344 33.432 l h -96.898 25.163 m -96.415 26.301 l -97.328 27.113 l -96.52 29.021 l -95.314 28.901 l -94.815 30.073 l -100.762 30.437 l -101.283 29.206 l -96.898 25.163 l -99.864 29.309 m -99.858 29.324 l -97.541 29.098 l -98.1 27.78 l h -98.099 20.289 m -97.816 21.445 l -100.982 24.503 l -100.979 24.519 l -97.286 23.617 l -97.019 24.711 l -102.475 26.044 l -102.757 24.889 l -99.567 21.824 l -99.57 21.809 l -103.287 22.715 l -103.554 21.622 l h -98.56 14.91 m -98.271 18.905 l -97.116 18.788 l -97.043 19.801 l -99.164 19.988 l -99.198 19.519 l -103.833 19.854 l -103.917 18.685 l -99.284 18.349 l -99.442 16.15 l -104.076 16.486 l -104.161 15.315 l h -100.834 8.615 m -99.167 8.783 -97.99 9.8 -98.174 11.598 c -98.342 13.255 -99.716 14.152 -101.38 13.984 c -103.045 13.813 -104.209 12.658 -104.041 11 c -103.858 9.203 -102.499 8.445 -100.834 8.615 c -99.186 11.496 m -99.088 10.546 -99.839 9.893 -100.953 9.781 c -102.064 9.668 -102.931 10.153 -103.03 11.102 c -103.126 12.052 -102.375 12.703 -101.262 12.817 c -100.148 12.929 -99.281 12.444 -99.186 11.496 c -101.261 6.369 m -101.58 7.498 l -102.273 7.245 -103.322 6.356 -102.826 4.595 c -102.479 3.361 -101.292 2.378 -99.298 2.94 c -97.572 3.426 -96.711 4.636 -97.162 6.24 c -97.484 7.383 -98.387 8.137 -99.803 7.998 c -99.487 6.877 l -99.12 6.873 -98.396 6.867 -98.129 5.918 c -97.897 5.098 -98.448 4.398 -99.615 4.07 c -101.225 3.615 -101.73 4.457 -101.847 4.871 c -102.121 5.842 -101.553 6.189 -101.261 6.369 c -99.379 0.668 m -99.871 1.732 l -100.515 1.374 -101.411 0.33 -100.64 -1.331 c -100.101 -2.495 -98.774 -3.276 -96.893 -2.404 c -95.268 -1.649 -94.61 -0.318 -95.31 1.192 c -95.81 2.272 -96.822 2.872 -98.196 2.51 c -97.707 1.452 l -97.346 1.508 -96.628 1.616 -96.214 0.723 c -95.855 -0.052 -96.287 -0.829 -97.386 -1.339 c -98.906 -2.043 -99.537 -1.294 -99.718 -0.903 c -100.143 0.013 -99.637 0.444 -99.379 0.668 c -91.276 -5.926 m -91.958 -4.896 l -93.138 -5.206 l -94.28 -3.476 l -93.513 -2.537 l -94.215 -1.475 l -97.807 -6.224 l -97.071 -7.343 l -91.276 -5.926 l -96.371 -6.103 m -96.379 -6.088 l -94.909 -4.284 l -94.12 -5.478 l h -2.722 14.92 m -2.722 25.516 -8.654 35.021 -18.046 41.493 c -49.006 14.897 l -18.018 -11.635 l -8.643 -5.164 -2.722 4.333 -2.722 14.92 c -92.406 14.92 m -92.406 -0.627 -79.639 -13.826 -61.908 -18.535 c -61.908 48.375 l -79.639 43.665 -92.406 30.466 -92.406 14.92 c -47.549 52.066 m -73.683 52.066 -94.946 35.358 -94.946 14.82 c -94.946 -5.716 -73.683 -22.424 -47.549 -22.424 c -21.415 -22.424 -0.154 -5.716 -0.154 14.82 c -0.154 35.358 -21.415 52.066 -47.549 52.066 c -47.549 -23.779 m -74.43 -23.779 -96.3 -6.463 -96.3 14.82 c -96.3 36.106 -74.43 53.421 -47.549 53.421 c -20.668 53.421 1.201 36.106 1.201 14.82 c 1.201 -6.463 -20.668 -23.779 -47.549 -23.779 c f Q EMC Q BT 1 0.68 0 0.12 k /GS1 gs /T1_1 1 Tf 0 Tc 0 Tw 33 0 0 33 125.0161 566.6835 Tm [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027)]TJ /T1_0 1 Tf 0.023 Tw 22 0 0 22 197.4109 540.2835 Tm [(\t)10(\013\215 2)38(3, \217\016)-23.3(1)75(, 2)25(02)50(4)]TJ ET 1 0.68 0 0.12 K 4 M 99.713 516.406 367.504 98.213 re S q 0 0 566.929 793.701 re W n 0 0 0 1 k /GS0 gs q 1 0 0 1 179.6088 727.7166 cm 0 0 m -1.715 -1.353 l -1.715 -2.815 l 0 -4.168 l 0 -2.837 l -0.967 -2.078 l 0 -1.32 l h -2.145 0 m -3.882 -1.353 l -3.882 -2.793 l -2.145 -4.179 l -2.145 -2.837 l -3.134 -2.056 l -2.145 -1.298 l h 5.192 2.838 m 3.422 2.838 l 0.441 -4.993 l 2.201 -4.993 l 2.839 -3.244 l 5.753 -3.244 l 6.369 -4.993 l 8.173 -4.993 l h 5.335 -1.991 m 3.257 -1.991 l 4.301 0.917 l h 14.08 -2.805 m 12.573 -2.805 l 12.452 -3.553 12.034 -3.949 11.363 -3.949 c 10.527 -3.949 10.043 -3.3 10.043 -2.166 c 10.043 -1 10.549 -0.318 11.396 -0.318 c 12.001 -0.318 12.408 -0.67 12.518 -1.297 c 14.047 -1.297 l 13.915 0.023 12.903 0.847 11.385 0.847 c 9.625 0.847 8.471 -0.362 8.471 -2.199 c 8.471 -3.971 9.614 -5.136 11.363 -5.136 c 12.87 -5.136 13.882 -4.279 14.08 -2.805 c 20.394 -2.805 m 18.887 -2.805 l 18.766 -3.553 18.348 -3.949 17.677 -3.949 c 16.841 -3.949 16.357 -3.3 16.357 -2.166 c 16.357 -1 16.863 -0.318 17.71 -0.318 c 18.315 -0.318 18.722 -0.67 18.832 -1.297 c 20.361 -1.297 l 20.229 0.023 19.217 0.847 17.699 0.847 c 15.939 0.847 14.785 -0.362 14.785 -2.199 c 14.785 -3.971 15.928 -5.136 17.677 -5.136 c 19.184 -5.136 20.196 -4.279 20.394 -2.805 c 26.994 -2.155 m 26.994 -0.351 25.84 0.847 24.09 0.847 c 22.308 0.847 21.132 -0.351 21.132 -2.155 c 21.132 -3.971 22.297 -5.169 24.068 -5.169 c 25.84 -5.169 26.994 -3.982 26.994 -2.155 c 25.433 -2.144 m 25.433 -3.311 24.927 -3.993 24.068 -3.993 c 23.199 -3.993 22.693 -3.322 22.693 -2.155 c 22.693 -1.022 23.21 -0.34 24.046 -0.34 c 24.916 -0.34 25.433 -1.011 25.433 -2.144 c 33.923 -6.665 m 33.923 -3.795 l 33.208 -3.795 l 33.208 0.682 l 31.659 0.682 l 31.659 -3.795 l 29.556 -3.795 l 29.556 0.682 l 28.007 0.682 l 28.007 -4.993 l 32.461 -4.993 l 32.461 -6.665 l h 39.962 -4.993 m 39.962 0.682 l 38.193 0.682 l 36.167 -3.157 l 36.167 0.682 l 34.673 0.682 l 34.673 -4.993 l 36.443 -4.993 l 38.468 -1.155 l 38.468 -4.993 l h 46.452 -4.993 m 46.243 -4.51 46.254 -3.971 46.254 -3.453 c 46.254 -1 l 46.254 0.583 44.925 0.847 43.78 0.847 c 42.141 0.847 41.239 0.199 41.151 -1.066 c 42.613 -1.066 l 42.723 -0.417 43.021 -0.197 43.736 -0.197 c 44.429 -0.197 44.76 -0.439 44.76 -0.956 c 44.76 -1.419 44.385 -1.507 43.373 -1.639 c 42.251 -1.782 40.899 -1.958 40.899 -3.442 c 40.899 -4.51 41.668 -5.158 42.922 -5.158 c 43.604 -5.158 44.275 -4.927 44.76 -4.444 c 44.782 -4.697 44.793 -4.785 44.87 -4.993 c h 44.749 -2.232 m 44.749 -2.87 l 44.749 -3.684 44.176 -4.136 43.362 -4.136 c 42.823 -4.136 42.503 -3.849 42.503 -3.376 c 42.503 -2.683 43.109 -2.617 43.648 -2.529 c 44.044 -2.463 44.385 -2.441 44.749 -2.232 c 53.393 -6.665 m 53.393 -3.795 l 52.678 -3.795 l 52.678 0.682 l 51.129 0.682 l 51.129 -3.795 l 49.026 -3.795 l 49.026 0.682 l 47.477 0.682 l 47.477 -4.993 l 51.931 -4.993 l 51.931 -6.665 l h 59.432 -4.993 m 59.432 0.682 l 57.662 0.682 l 55.637 -3.157 l 55.637 0.682 l 54.143 0.682 l 54.143 -4.993 l 55.912 -4.993 l 57.938 -1.155 l 57.938 -4.993 l h 65.735 -4.993 m 65.735 0.682 l 62.303 0.682 l 61.204 0.682 60.423 -0.043 60.423 -1.044 c 60.423 -1.98 61.061 -2.628 61.863 -2.76 c 59.983 -4.993 l 61.896 -4.993 l 63.525 -2.892 l 64.185 -2.892 l 64.185 -4.993 l h 64.185 -1.771 m 62.942 -1.771 l 62.215 -1.771 62.006 -1.54 62.006 -1.099 c 62.006 -0.67 62.226 -0.439 62.942 -0.439 c 64.185 -0.439 l h 75.811 -4.993 m 73.303 -1.518 l 75.503 0.682 l 73.666 0.682 l 71.587 -1.562 l 71.587 0.682 l 70.059 0.682 l 70.059 -4.993 l 71.587 -4.993 l 71.587 -3.256 l 72.28 -2.552 l 73.919 -4.993 l h 81.828 -2.155 m 81.828 -0.351 80.674 0.847 78.925 0.847 c 77.142 0.847 75.966 -0.351 75.966 -2.155 c 75.966 -3.971 77.131 -5.169 78.903 -5.169 c 80.674 -5.169 81.828 -3.982 81.828 -2.155 c 80.267 -2.144 m 80.267 -3.311 79.761 -3.993 78.903 -3.993 c 78.033 -3.993 77.527 -3.322 77.527 -2.155 c 77.527 -1.022 78.044 -0.34 78.881 -0.34 c 79.75 -0.34 80.267 -1.011 80.267 -2.144 c 87.933 -4.993 m 87.933 0.682 l 83.38 0.682 l 83.292 -2.694 l 83.27 -3.509 83.039 -3.872 82.588 -3.872 c 82.423 -3.872 82.258 -3.839 82.148 -3.817 c 82.148 -5.059 l 82.313 -5.125 82.775 -5.169 82.995 -5.169 c 84.71 -5.169 84.776 -3.696 84.82 -2.518 c 84.886 -0.516 l 86.383 -0.516 l 86.383 -4.993 l h 94.874 -2.155 m 94.874 -0.351 93.72 0.847 91.97 0.847 c 90.188 0.847 89.012 -0.351 89.012 -2.155 c 89.012 -3.971 90.177 -5.169 91.948 -5.169 c 93.72 -5.169 94.874 -3.982 94.874 -2.155 c 93.313 -2.144 m 93.313 -3.311 92.807 -3.993 91.948 -3.993 c 91.079 -3.993 90.573 -3.322 90.573 -2.155 c 90.573 -1.022 91.09 -0.34 91.926 -0.34 c 92.796 -0.34 93.313 -1.011 93.313 -2.144 c 101.21 -4.993 m 101.21 0.682 l 95.92 0.682 l 95.92 -4.993 l 97.47 -4.993 l 97.47 -0.516 l 99.66 -0.516 l 99.66 -4.993 l h 103.894 0.682 m 102.421 0.682 l 102.421 -7.006 l 103.971 -7.006 l 103.971 -4.29 l 104.389 -4.872 105.005 -5.136 105.72 -5.136 c 107.205 -5.136 108.184 -3.971 108.184 -2.189 c 108.184 -0.363 107.183 0.836 105.654 0.836 c 104.928 0.836 104.312 0.561 103.894 -0.022 c h 105.269 -0.418 m 106.106 -0.418 106.623 -1.078 106.623 -2.189 c 106.623 -3.267 106.117 -3.916 105.28 -3.916 c 104.422 -3.916 103.916 -3.267 103.916 -2.167 c 103.916 -1.067 104.422 -0.418 105.269 -0.418 c 114.838 -2.155 m 114.838 -0.351 113.685 0.847 111.935 0.847 c 110.153 0.847 108.977 -0.351 108.977 -2.155 c 108.977 -3.971 110.142 -5.169 111.913 -5.169 c 113.685 -5.169 114.838 -3.982 114.838 -2.155 c 113.278 -2.144 m 113.278 -3.311 112.772 -3.993 111.913 -3.993 c 111.044 -3.993 110.538 -3.322 110.538 -2.155 c 110.538 -1.022 111.055 -0.34 111.891 -0.34 c 112.761 -0.34 113.278 -1.011 113.278 -2.144 c 121.658 -4.993 m 119.15 -1.518 l 121.35 0.682 l 119.513 0.682 l 117.434 -1.562 l 117.434 0.682 l 115.907 0.682 l 115.907 -4.993 l 117.434 -4.993 l 117.434 -3.256 l 118.127 -2.552 l 119.766 -4.993 l h 126.982 -0.516 m 126.982 0.682 l 121.693 0.682 l 121.693 -0.516 l 123.563 -0.516 l 123.563 -4.993 l 125.112 -4.993 l 125.112 -0.516 l h 133.175 -2.155 m 133.175 -0.351 132.021 0.847 130.272 0.847 c 128.49 0.847 127.314 -0.351 127.314 -2.155 c 127.314 -3.971 128.479 -5.169 130.25 -5.169 c 132.021 -5.169 133.175 -3.982 133.175 -2.155 c 131.615 -2.144 m 131.615 -3.311 131.109 -3.993 130.25 -3.993 c 129.381 -3.993 128.874 -3.322 128.874 -2.155 c 128.874 -1.022 129.392 -0.34 130.228 -0.34 c 131.098 -0.34 131.615 -1.011 131.615 -2.144 c 139.28 -4.993 m 139.28 0.682 l 134.728 0.682 l 134.64 -2.694 l 134.618 -3.509 134.387 -3.872 133.936 -3.872 c 133.771 -3.872 133.606 -3.839 133.496 -3.817 c 133.496 -5.059 l 133.661 -5.125 134.123 -5.169 134.343 -5.169 c 136.058 -5.169 136.123 -3.696 136.167 -2.518 c 136.233 -0.516 l 137.731 -0.516 l 137.731 -4.993 l h 146.221 -2.155 m 146.221 -0.351 145.067 0.847 143.318 0.847 c 141.536 0.847 140.36 -0.351 140.36 -2.155 c 140.36 -3.971 141.525 -5.169 143.296 -5.169 c 145.067 -5.169 146.221 -3.982 146.221 -2.155 c 144.661 -2.144 m 144.661 -3.311 144.154 -3.993 143.296 -3.993 c 142.427 -3.993 141.92 -3.322 141.92 -2.155 c 141.92 -1.022 142.438 -0.34 143.274 -0.34 c 144.143 -0.34 144.661 -1.011 144.661 -2.144 c 151.556 -0.516 m 151.556 0.682 l 147.268 0.682 l 147.268 -4.993 l 148.817 -4.993 l 148.817 -0.516 l h 157.639 -2.155 m 157.639 -0.351 156.485 0.847 154.736 0.847 c 152.954 0.847 151.778 -0.351 151.778 -2.155 c 151.778 -3.971 152.943 -5.169 154.714 -5.169 c 156.485 -5.169 157.639 -3.982 157.639 -2.155 c 156.079 -2.144 m 156.079 -3.311 155.572 -3.993 154.714 -3.993 c 153.844 -3.993 153.338 -3.322 153.338 -2.155 c 153.338 -1.022 153.855 -0.34 154.692 -0.34 c 155.561 -0.34 156.079 -1.011 156.079 -2.144 c 158.642 0.682 m 158.642 -4.993 l 162.062 -4.993 l 163.129 -4.993 163.986 -4.41 163.986 -3.299 c 163.986 -2.518 163.536 -2.078 162.953 -1.914 c 163.415 -1.705 163.722 -1.298 163.722 -0.747 c 163.722 0.265 162.909 0.682 161.908 0.682 c h 160.18 -1.595 m 160.18 -0.307 l 161.215 -0.307 l 161.699 -0.307 162.139 -0.395 162.139 -0.945 c 162.139 -1.507 161.677 -1.595 161.215 -1.595 c h 160.18 -3.982 m 160.18 -2.474 l 161.27 -2.474 l 161.831 -2.474 162.371 -2.573 162.371 -3.233 c 162.371 -3.883 161.875 -3.982 161.336 -3.982 c h 168.211 2.838 m 168.211 -4.993 l 169.915 -4.993 l 169.915 -2.177 l 171.676 -2.177 l 173.249 -2.177 174.458 -1.385 174.458 0.32 c 174.458 2.047 173.282 2.838 171.588 2.838 c h 169.915 1.431 m 171.456 1.431 l 172.215 1.431 172.787 1.134 172.787 0.298 c 172.787 -0.572 172.215 -0.825 171.445 -0.825 c 169.915 -0.825 l h 181.069 -2.155 m 181.069 -0.351 179.915 0.847 178.166 0.847 c 176.383 0.847 175.207 -0.351 175.207 -2.155 c 175.207 -3.971 176.372 -5.169 178.144 -5.169 c 179.915 -5.169 181.069 -3.982 181.069 -2.155 c 179.508 -2.144 m 179.508 -3.311 179.002 -3.993 178.144 -3.993 c 177.274 -3.993 176.768 -3.322 176.768 -2.155 c 176.768 -1.022 177.285 -0.34 178.122 -0.34 c 178.991 -0.34 179.508 -1.011 179.508 -2.144 c 187.504 -2.805 m 185.997 -2.805 l 185.876 -3.553 185.458 -3.949 184.787 -3.949 c 183.951 -3.949 183.467 -3.3 183.467 -2.166 c 183.467 -1 183.973 -0.318 184.82 -0.318 c 185.425 -0.318 185.832 -0.67 185.942 -1.297 c 187.471 -1.297 l 187.339 0.023 186.327 0.847 184.809 0.847 c 183.049 0.847 181.895 -0.362 181.895 -2.199 c 181.895 -3.971 183.038 -5.136 184.787 -5.136 c 186.294 -5.136 187.306 -4.279 187.504 -2.805 c 193.818 -2.805 m 192.311 -2.805 l 192.19 -3.553 191.772 -3.949 191.101 -3.949 c 190.265 -3.949 189.781 -3.3 189.781 -2.166 c 189.781 -1 190.287 -0.318 191.134 -0.318 c 191.739 -0.318 192.146 -0.67 192.256 -1.297 c 193.785 -1.297 l 193.653 0.023 192.641 0.847 191.123 0.847 c 189.363 0.847 188.209 -0.362 188.209 -2.199 c 188.209 -3.971 189.352 -5.136 191.101 -5.136 c 192.608 -5.136 193.62 -4.279 193.818 -2.805 c 200.033 -4.993 m 200.033 0.682 l 198.263 0.682 l 196.238 -3.157 l 196.238 0.682 l 194.743 0.682 l 194.743 -4.993 l 196.513 -4.993 l 198.538 -1.155 l 198.538 -4.993 l h 206.556 -4.993 m 206.556 0.682 l 204.786 0.682 l 202.76 -3.157 l 202.76 0.682 l 201.266 0.682 l 201.266 -4.993 l 203.036 -4.993 l 205.061 -1.155 l 205.061 -4.993 l h 209.857 0.022 m 209.857 -1.309 l 210.857 -2.1 l 209.857 -2.87 l 209.857 -4.168 l 211.593 -2.815 l 211.593 -1.364 l h 207.712 0.011 m 207.712 -1.331 l 208.69 -2.089 l 207.712 -2.859 l 207.712 -4.146 l 209.426 -2.804 l 209.426 -1.353 l h f Q q 1 0 0 1 162.8898 742.8416 cm 0 0 m -2.344 0 -3.882 -1.627 -3.882 -4.113 c -3.882 -6.567 -2.333 -8.205 -0.011 -8.205 c 2.289 -8.205 3.838 -6.556 3.838 -4.113 c 3.838 -1.66 2.289 0 0 0 c -0.022 -1.407 m 1.287 -1.407 2.102 -2.43 2.102 -4.08 c 2.102 -5.753 1.298 -6.787 0 -6.787 c -1.331 -6.776 -2.146 -5.764 -2.146 -4.08 c -2.146 -2.452 -1.32 -1.407 -0.022 -1.407 c 10.526 -5.246 m 10.526 -3.486 9.372 -2.343 7.92 -2.343 c 6.621 -2.343 5.951 -3.189 5.676 -3.948 c 5.643 -3.948 l 5.764 -2.837 6.214 -1.814 7.634 -1.682 c 8.955 -1.561 10.076 -1.374 10.274 0.055 c 8.79 0.055 l 8.636 -0.275 7.766 -0.209 7.106 -0.385 c 5.027 -0.934 4.819 -3.013 4.819 -4.696 c 4.819 -6.358 5.522 -8.183 7.568 -8.183 c 9.394 -8.183 10.526 -7.029 10.526 -5.246 c 8.966 -5.235 m 8.966 -6.38 8.47 -7.007 7.678 -7.007 c 6.875 -7.007 6.379 -6.391 6.379 -5.246 c 6.379 -4.135 6.886 -3.497 7.656 -3.497 c 8.47 -3.497 8.966 -4.124 8.966 -5.235 c 11.562 -8.018 m 18.788 -8.018 l 18.788 -9.69 l 20.25 -9.69 l 20.25 -6.82 l 19.535 -6.82 l 19.535 -2.343 l 17.986 -2.343 l 17.986 -6.82 l 16.323 -6.82 l 16.323 -2.343 l 14.774 -2.343 l 14.774 -6.82 l 13.111 -6.82 l 13.111 -2.343 l 11.562 -2.343 l h 26.311 -6.258 m 24.817 -6.258 l 24.585 -6.831 24.233 -7.084 23.661 -7.084 c 22.824 -7.084 22.351 -6.556 22.329 -5.576 c 26.399 -5.576 l 26.399 -5.422 l 26.399 -3.431 25.311 -2.178 23.595 -2.178 c 21.945 -2.178 20.747 -3.453 20.747 -5.213 c 20.747 -6.996 21.901 -8.183 23.65 -8.183 c 24.937 -8.183 25.96 -7.49 26.311 -6.258 c 24.817 -4.587 m 22.329 -4.587 l 22.417 -3.794 22.901 -3.31 23.595 -3.31 c 24.376 -3.31 24.751 -3.893 24.817 -4.587 c 28.764 -2.343 m 27.291 -2.343 l 27.291 -10.031 l 28.841 -10.031 l 28.841 -7.315 l 29.259 -7.897 29.876 -8.161 30.591 -8.161 c 32.076 -8.161 33.054 -6.996 33.054 -5.214 c 33.054 -3.388 32.054 -2.189 30.525 -2.189 c 29.799 -2.189 29.182 -2.464 28.764 -3.047 c h 30.14 -3.443 m 30.976 -3.443 31.493 -4.103 31.493 -5.214 c 31.493 -6.292 30.987 -6.941 30.151 -6.941 c 29.292 -6.941 28.786 -6.292 28.786 -5.192 c 28.786 -4.092 29.292 -3.443 30.14 -3.443 c 39.709 -5.18 m 39.709 -3.376 38.555 -2.178 36.806 -2.178 c 35.023 -2.178 33.847 -3.376 33.847 -5.18 c 33.847 -6.996 35.012 -8.194 36.784 -8.194 c 38.555 -8.194 39.709 -7.007 39.709 -5.18 c 38.148 -5.169 m 38.148 -6.336 37.642 -7.018 36.784 -7.018 c 35.914 -7.018 35.408 -6.347 35.408 -5.18 c 35.408 -4.047 35.925 -3.365 36.762 -3.365 c 37.631 -3.365 38.148 -4.036 38.148 -5.169 c 46.144 -5.83 m 44.637 -5.83 l 44.516 -6.578 44.098 -6.974 43.427 -6.974 c 42.591 -6.974 42.107 -6.325 42.107 -5.191 c 42.107 -4.025 42.613 -3.343 43.46 -3.343 c 44.065 -3.343 44.472 -3.695 44.582 -4.322 c 46.111 -4.322 l 45.979 -3.002 44.967 -2.178 43.449 -2.178 c 41.689 -2.178 40.535 -3.387 40.535 -5.224 c 40.535 -6.996 41.678 -8.161 43.427 -8.161 c 44.934 -8.161 45.946 -7.304 46.144 -5.83 c 52.458 -5.83 m 50.951 -5.83 l 50.83 -6.578 50.412 -6.974 49.741 -6.974 c 48.905 -6.974 48.421 -6.325 48.421 -5.191 c 48.421 -4.025 48.927 -3.343 49.774 -3.343 c 50.379 -3.343 50.786 -3.695 50.896 -4.322 c 52.425 -4.322 l 52.293 -3.002 51.281 -2.178 49.763 -2.178 c 48.003 -2.178 46.849 -3.387 46.849 -5.224 c 46.849 -6.996 47.992 -8.161 49.741 -8.161 c 51.248 -8.161 52.26 -7.304 52.458 -5.83 c 58.673 -8.018 m 58.673 -2.343 l 56.903 -2.343 l 54.878 -6.182 l 54.878 -2.343 l 53.383 -2.343 l 53.383 -8.018 l 55.153 -8.018 l 57.178 -4.18 l 57.178 -8.018 l h 63.723 -0.187 m 63.624 -0.693 63.14 -0.913 62.545 -0.913 c 61.951 -0.913 61.467 -0.693 61.368 -0.187 c 60.752 -0.187 l 60.752 -1.319 61.478 -1.77 62.545 -1.77 c 63.613 -1.77 64.338 -1.319 64.338 -0.187 c h 65.196 -8.018 m 65.196 -2.343 l 63.426 -2.343 l 61.401 -6.182 l 61.401 -2.343 l 59.906 -2.343 l 59.906 -8.018 l 61.676 -8.018 l 63.701 -4.18 l 63.701 -8.018 l h 71.817 -5.83 m 70.31 -5.83 l 70.189 -6.578 69.771 -6.974 69.1 -6.974 c 68.264 -6.974 67.78 -6.325 67.78 -5.191 c 67.78 -4.025 68.286 -3.343 69.133 -3.343 c 69.738 -3.343 70.145 -3.695 70.255 -4.322 c 71.784 -4.322 l 71.652 -3.002 70.64 -2.178 69.122 -2.178 c 67.363 -2.178 66.209 -3.387 66.209 -5.224 c 66.209 -6.996 67.352 -8.161 69.1 -8.161 c 70.607 -8.161 71.619 -7.304 71.817 -5.83 c 78.516 -8.018 m 76.008 -4.543 l 78.208 -2.343 l 76.371 -2.343 l 74.292 -4.587 l 74.292 -2.343 l 72.765 -2.343 l 72.765 -8.018 l 74.292 -8.018 l 74.292 -6.281 l 74.985 -5.577 l 76.624 -8.018 l h 84.313 -8.018 m 84.104 -7.535 84.115 -6.995 84.115 -6.478 c 84.115 -4.025 l 84.115 -2.442 82.785 -2.178 81.641 -2.178 c 80.001 -2.178 79.1 -2.826 79.012 -4.091 c 80.474 -4.091 l 80.584 -3.442 80.881 -3.222 81.597 -3.222 c 82.29 -3.222 82.621 -3.464 82.621 -3.981 c 82.621 -4.444 82.246 -4.532 81.234 -4.664 c 80.111 -4.807 78.76 -4.982 78.76 -6.467 c 78.76 -7.535 79.529 -8.183 80.782 -8.183 c 81.465 -8.183 82.136 -7.952 82.621 -7.469 c 82.643 -7.722 82.654 -7.81 82.73 -8.018 c h 82.61 -5.257 m 82.61 -5.895 l 82.61 -6.709 82.037 -7.161 81.223 -7.161 c 80.683 -7.161 80.364 -6.874 80.364 -6.401 c 80.364 -5.708 80.97 -5.642 81.509 -5.554 c 81.905 -5.488 82.246 -5.466 82.61 -5.257 c 90.44 -8.018 m 90.44 -2.343 l 87.008 -2.343 l 85.909 -2.343 85.128 -3.068 85.128 -4.069 c 85.128 -5.005 85.766 -5.653 86.568 -5.785 c 84.688 -8.018 l 86.601 -8.018 l 88.23 -5.917 l 88.89 -5.917 l 88.89 -8.018 l h 88.89 -4.796 m 87.647 -4.796 l 86.92 -4.796 86.711 -4.565 86.711 -4.124 c 86.711 -3.695 86.931 -3.464 87.647 -3.464 c 88.89 -3.464 l h 100.417 -5.18 m 100.417 -3.376 99.263 -2.178 97.514 -2.178 c 95.731 -2.178 94.555 -3.376 94.555 -5.18 c 94.555 -6.996 95.72 -8.194 97.492 -8.194 c 99.263 -8.194 100.417 -7.007 100.417 -5.18 c 98.856 -5.169 m 98.856 -6.336 98.35 -7.018 97.492 -7.018 c 96.622 -7.018 96.116 -6.347 96.116 -5.18 c 96.116 -4.047 96.633 -3.365 97.47 -3.365 c 98.339 -3.365 98.856 -4.036 98.856 -5.169 c 107.116 -5.246 m 107.116 -3.486 105.962 -2.343 104.51 -2.343 c 103.211 -2.343 102.54 -3.189 102.265 -3.948 c 102.232 -3.948 l 102.353 -2.837 102.804 -1.814 104.224 -1.682 c 105.544 -1.561 106.665 -1.374 106.863 0.055 c 105.379 0.055 l 105.225 -0.275 104.356 -0.209 103.695 -0.385 c 101.617 -0.934 101.408 -3.013 101.408 -4.696 c 101.408 -6.358 102.112 -8.183 104.157 -8.183 c 105.984 -8.183 107.116 -7.029 107.116 -5.246 c 105.555 -5.235 m 105.555 -6.38 105.06 -7.007 104.268 -7.007 c 103.464 -7.007 102.969 -6.391 102.969 -5.246 c 102.969 -4.135 103.475 -3.497 104.246 -3.497 c 105.06 -3.497 105.555 -4.124 105.555 -5.235 c 108.151 -8.018 m 115.377 -8.018 l 115.377 -9.69 l 116.84 -9.69 l 116.84 -6.82 l 116.125 -6.82 l 116.125 -2.343 l 114.575 -2.343 l 114.575 -6.82 l 112.913 -6.82 l 112.913 -2.343 l 111.363 -2.343 l 111.363 -6.82 l 109.701 -6.82 l 109.701 -2.343 l 108.151 -2.343 l h 122.901 -6.258 m 121.406 -6.258 l 121.175 -6.831 120.823 -7.084 120.25 -7.084 c 119.414 -7.084 118.941 -6.556 118.919 -5.576 c 122.989 -5.576 l 122.989 -5.422 l 122.989 -3.431 121.901 -2.178 120.184 -2.178 c 118.534 -2.178 117.336 -3.453 117.336 -5.213 c 117.336 -6.996 118.49 -8.183 120.239 -8.183 c 121.527 -8.183 122.549 -7.49 122.901 -6.258 c 121.406 -4.587 m 118.919 -4.587 l 119.007 -3.794 119.491 -3.31 120.184 -3.31 c 120.966 -3.31 121.34 -3.893 121.406 -4.587 c 129.292 -5.83 m 127.785 -5.83 l 127.664 -6.578 127.246 -6.974 126.575 -6.974 c 125.739 -6.974 125.255 -6.325 125.255 -5.191 c 125.255 -4.025 125.761 -3.343 126.608 -3.343 c 127.213 -3.343 127.62 -3.695 127.73 -4.322 c 129.259 -4.322 l 129.127 -3.002 128.115 -2.178 126.597 -2.178 c 124.837 -2.178 123.683 -3.387 123.683 -5.224 c 123.683 -6.996 124.826 -8.161 126.575 -8.161 c 128.082 -8.161 129.094 -7.304 129.292 -5.83 c 134.803 -3.541 m 134.803 -2.343 l 129.513 -2.343 l 129.513 -3.541 l 131.383 -3.541 l 131.383 -8.018 l 132.933 -8.018 l 132.933 -3.541 l h 135.475 -2.343 m 135.475 -8.018 l 138.896 -8.018 l 139.962 -8.018 140.82 -7.435 140.82 -6.324 c 140.82 -5.543 140.369 -5.103 139.786 -4.938 c 140.248 -4.73 140.556 -4.323 140.556 -3.772 c 140.556 -2.76 139.743 -2.343 138.742 -2.343 c h 137.014 -4.62 m 137.014 -3.332 l 138.048 -3.332 l 138.533 -3.332 138.973 -3.42 138.973 -3.97 c 138.973 -4.532 138.511 -4.62 138.048 -4.62 c h 137.014 -7.007 m 137.014 -5.499 l 138.103 -5.499 l 138.665 -5.499 139.204 -5.598 139.204 -6.258 c 139.204 -6.908 138.709 -7.007 138.169 -7.007 c h 147.145 -6.258 m 145.65 -6.258 l 145.419 -6.831 145.067 -7.084 144.494 -7.084 c 143.658 -7.084 143.185 -6.556 143.163 -5.576 c 147.232 -5.576 l 147.232 -5.422 l 147.232 -3.431 146.144 -2.178 144.428 -2.178 c 142.778 -2.178 141.58 -3.453 141.58 -5.213 c 141.58 -6.996 142.734 -8.183 144.483 -8.183 c 145.771 -8.183 146.793 -7.49 147.145 -6.258 c 145.65 -4.587 m 143.163 -4.587 l 143.251 -3.794 143.735 -3.31 144.428 -3.31 c 145.21 -3.31 145.584 -3.893 145.65 -4.587 c 153.436 -8.018 m 153.436 -2.343 l 151.887 -2.343 l 151.887 -4.4 l 149.696 -4.4 l 149.696 -2.343 l 148.147 -2.343 l 148.147 -8.018 l 149.696 -8.018 l 149.696 -5.631 l 151.887 -5.631 l 151.887 -8.018 l h 159.959 -8.018 m 159.959 -2.343 l 158.41 -2.343 l 158.41 -4.4 l 156.219 -4.4 l 156.219 -2.343 l 154.67 -2.343 l 154.67 -8.018 l 156.219 -8.018 l 156.219 -5.631 l 158.41 -5.631 l 158.41 -8.018 l h 166.449 -8.018 m 166.24 -7.535 166.251 -6.995 166.251 -6.478 c 166.251 -4.025 l 166.251 -2.442 164.921 -2.178 163.777 -2.178 c 162.137 -2.178 161.236 -2.826 161.148 -4.091 c 162.61 -4.091 l 162.72 -3.442 163.017 -3.222 163.733 -3.222 c 164.426 -3.222 164.756 -3.464 164.756 -3.981 c 164.756 -4.444 164.382 -4.532 163.37 -4.664 c 162.247 -4.807 160.895 -4.982 160.895 -6.467 c 160.895 -7.535 161.665 -8.183 162.918 -8.183 c 163.601 -8.183 164.272 -7.952 164.756 -7.469 c 164.778 -7.722 164.789 -7.81 164.866 -8.018 c h 164.745 -5.257 m 164.745 -5.895 l 164.745 -6.709 164.173 -7.161 163.359 -7.161 c 162.819 -7.161 162.5 -6.874 162.5 -6.401 c 162.5 -5.708 163.105 -5.642 163.645 -5.554 c 164.041 -5.488 164.382 -5.466 164.745 -5.257 c 172.576 -8.018 m 172.576 -2.343 l 169.144 -2.343 l 168.045 -2.343 167.264 -3.068 167.264 -4.069 c 167.264 -5.005 167.902 -5.653 168.704 -5.785 c 166.824 -8.018 l 168.737 -8.018 l 170.366 -5.917 l 171.026 -5.917 l 171.026 -8.018 l h 171.026 -4.796 m 169.783 -4.796 l 169.056 -4.796 168.847 -4.565 168.847 -4.124 c 168.847 -3.695 169.067 -3.464 169.783 -3.464 c 171.026 -3.464 l h 182.553 -5.18 m 182.553 -3.376 181.399 -2.178 179.65 -2.178 c 177.867 -2.178 176.691 -3.376 176.691 -5.18 c 176.691 -6.996 177.856 -8.194 179.628 -8.194 c 181.399 -8.194 182.553 -7.007 182.553 -5.18 c 180.992 -5.169 m 180.992 -6.336 180.486 -7.018 179.628 -7.018 c 178.758 -7.018 178.252 -6.347 178.252 -5.18 c 178.252 -4.047 178.769 -3.365 179.606 -3.365 c 180.475 -3.365 180.992 -4.036 180.992 -5.169 c 185.05 -2.343 m 183.577 -2.343 l 183.577 -10.031 l 185.127 -10.031 l 185.127 -7.315 l 185.545 -7.897 186.161 -8.161 186.877 -8.161 c 188.362 -8.161 189.34 -6.996 189.34 -5.214 c 189.34 -3.388 188.34 -2.189 186.811 -2.189 c 186.084 -2.189 185.468 -2.464 185.05 -3.047 c h 186.425 -3.443 m 187.262 -3.443 187.779 -4.103 187.779 -5.214 c 187.779 -6.292 187.273 -6.941 186.436 -6.941 c 185.578 -6.941 185.072 -6.292 185.072 -5.192 c 185.072 -4.092 185.578 -3.443 186.425 -3.443 c 194.609 -3.541 m 194.609 -2.343 l 190.32 -2.343 l 190.32 -8.018 l 191.87 -8.018 l 191.87 -3.541 l h 200.274 -8.018 m 200.065 -7.535 200.076 -6.995 200.076 -6.478 c 200.076 -4.025 l 200.076 -2.442 198.746 -2.178 197.602 -2.178 c 195.962 -2.178 195.061 -2.826 194.973 -4.091 c 196.435 -4.091 l 196.545 -3.442 196.842 -3.222 197.557 -3.222 c 198.251 -3.222 198.581 -3.464 198.581 -3.981 c 198.581 -4.444 198.207 -4.532 197.194 -4.664 c 196.072 -4.807 194.72 -4.982 194.72 -6.467 c 194.72 -7.535 195.489 -8.183 196.743 -8.183 c 197.425 -8.183 198.097 -7.952 198.581 -7.469 c 198.603 -7.722 198.614 -7.81 198.691 -8.018 c h 198.57 -5.257 m 198.57 -5.895 l 198.57 -6.709 197.998 -7.161 197.183 -7.161 c 196.644 -7.161 196.325 -6.874 196.325 -6.401 c 196.325 -5.708 196.93 -5.642 197.469 -5.554 c 197.866 -5.488 198.207 -5.466 198.57 -5.257 c 206.621 -8.018 m 206.621 -2.343 l 205.071 -2.343 l 205.071 -4.4 l 202.881 -4.4 l 202.881 -2.343 l 201.331 -2.343 l 201.331 -8.018 l 202.881 -8.018 l 202.881 -5.631 l 205.071 -5.631 l 205.071 -8.018 l h 213.143 -8.018 m 213.143 -2.343 l 211.374 -2.343 l 209.348 -6.182 l 209.348 -2.343 l 207.854 -2.343 l 207.854 -8.018 l 209.624 -8.018 l 211.649 -4.18 l 211.649 -8.018 l h 219.314 -6.335 m 219.314 -5.345 218.644 -5.048 218.105 -4.982 c 218.105 -4.96 l 218.589 -4.884 219.128 -4.356 219.128 -3.706 c 219.128 -2.65 218.248 -2.178 216.752 -2.178 c 215.453 -2.178 214.233 -2.672 214.19 -3.992 c 215.64 -3.992 l 215.728 -3.398 216.092 -3.211 216.719 -3.211 c 217.324 -3.211 217.611 -3.508 217.611 -3.849 c 217.611 -4.422 217.192 -4.587 216.532 -4.587 c 216.125 -4.587 l 216.125 -5.565 l 216.73 -5.565 l 217.413 -5.565 217.71 -5.884 217.71 -6.357 c 217.71 -6.787 217.402 -7.117 216.697 -7.117 c 215.982 -7.117 215.541 -6.787 215.486 -6.17 c 214.003 -6.17 l 214.025 -7.622 215.245 -8.183 216.664 -8.183 c 218.248 -8.183 219.314 -7.567 219.314 -6.335 c 225.54 -8.018 m 225.331 -7.535 225.342 -6.995 225.342 -6.478 c 225.342 -4.025 l 225.342 -2.442 224.012 -2.178 222.868 -2.178 c 221.229 -2.178 220.327 -2.826 220.239 -4.091 c 221.701 -4.091 l 221.811 -3.442 222.109 -3.222 222.824 -3.222 c 223.517 -3.222 223.848 -3.464 223.848 -3.981 c 223.848 -4.444 223.473 -4.532 222.461 -4.664 c 221.338 -4.807 219.987 -4.982 219.987 -6.467 c 219.987 -7.535 220.756 -8.183 222.009 -8.183 c 222.692 -8.183 223.363 -7.952 223.848 -7.469 c 223.87 -7.722 223.881 -7.81 223.957 -8.018 c h 223.837 -5.257 m 223.837 -5.895 l 223.837 -6.709 223.264 -7.161 222.45 -7.161 c 221.91 -7.161 221.591 -6.874 221.591 -6.401 c 221.591 -5.708 222.197 -5.642 222.736 -5.554 c 223.132 -5.488 223.473 -5.466 223.837 -5.257 c 232.481 -9.69 m 232.481 -6.82 l 231.766 -6.82 l 231.766 -2.343 l 230.216 -2.343 l 230.216 -6.82 l 228.114 -6.82 l 228.114 -2.343 l 226.564 -2.343 l 226.564 -8.018 l 231.019 -8.018 l 231.019 -9.69 l h 238.52 -8.018 m 238.52 -2.343 l 236.75 -2.343 l 234.725 -6.182 l 234.725 -2.343 l 233.23 -2.343 l 233.23 -8.018 l 235 -8.018 l 237.025 -4.18 l 237.025 -8.018 l h 244.823 -8.018 m 244.823 -2.343 l 241.391 -2.343 l 240.292 -2.343 239.511 -3.068 239.511 -4.069 c 239.511 -5.005 240.149 -5.653 240.951 -5.785 c 239.071 -8.018 l 240.984 -8.018 l 242.613 -5.917 l 243.273 -5.917 l 243.273 -8.018 l h 243.273 -4.796 m 242.029 -4.796 l 241.303 -4.796 241.094 -4.565 241.094 -4.124 c 241.094 -3.695 241.314 -3.464 242.029 -3.464 c 243.273 -3.464 l h f Q Q BT /T1_2 1 Tf 10 0 0 10 42.5197 400.8991 Tm [(\037)-11(\036\035\034\033 \035\034\036\032\031\030\027\027 \027\026)-23.3(\027\025\036\032\024\034\023\022-)-46.9(\021\020\035\034\036\027\024\034\023\022:)]TJ 0 0 0 1 k /GS0 gs /T1_0 1 Tf 0 -1.2 TD [(\005)10(\003. \032\220\003\235\215\220 \026)-10(\007\002\003\235, \007. 2, \240\013\006\255\200\220, 1)150(2)38(3)50(4)50(2)38(3)]TJ 0 -1.767 TD [(\024)50(\b\003./\202\220\255)21(\006:)]TJ /Span<>> BDC [( )-244( )]TJ EMC 4.87 0 Td [(8 \(4)25(99\) 64)50(2-5)25(4-4)100(1)75(, \007\013\203. 1)150(2-7)137(1)]TJ 0 Tw ( )Tj 0.023 Tw 0 -1.2 TD [(8 \(4)25(99\) 1)112(99-00-68)]TJ -4.87 -1.2 Td (E-mail: )Tj /Span<>> BDC ( )Tj EMC /T1_2 1 Tf 0 Tw 2.913 0 Td [(pr)10(oc)-10(tologia@mail.ru)]TJ ( )Tj T* [(k)21(olopr)10(oktologia@akr)-61.8(-online)-31(.ru)]TJ 0.01 Tc 0.018 Tw -2.908 -1.767 Td [(\017\037\016\r)5( \f\013\n\t\037)-20(\b\037)-21(:)]TJ /T1_1 1 Tf 0 Tc 0 Tw 1.412 -1.2 Td [(www)31(.r)10(upr)20(octology)52.1(.com)]TJ /T1_2 1 Tf 0.01 Tc 0.018 Tw -1.412 -1.767 Td [(\037\n)31(\007\006\005)5( \f\013\n\t\037)-20(\b\037)-21(:)]TJ /T1_0 1 Tf 0 Tc 0 Tw 1.412 -1.2 Td [(www)42(.new)42(.gnck.ru)]TJ T* [(www)42(.akr-online.ru)]TJ /T1_1 1 Tf 0.01 Tc -0.01 Tw -1.417 -1.767 Td [(h)-0.9(t)-22.1(t)-5.8(p)6.1(s)9.4(:)40.1(/)213.5(/)133.2(do)1.8(i)4.8(.)18.8(or)7.4(g)9.5(/)95.2(1)58.6(0)16.8(.3)21.9(3)22.7(8)31.4(7)38.7(8)70.6(/)69.5(2)18.1(0)29.5(7)28(3)-7.9(-)20.1(7)59.9(5)21.7(5)18.8(6)]TJ /T1_0 1 Tf 0 Tc 0.33 Tw 0 -1.767 TD [(\204\003\b\255\t\205\013\n\n\220\235 \200\b\205\006\002\235 \206\005\205\ \n\220\003\220 \t)13(\220\255\206\b \004\205\b\007\006\t)13.1(\220\200\003\b\n\220 )]TJ -0.036 Tw 0 -1.2 TD [(\n\220\016)36(\006\220\201\t)10(\b \n\220\005)10(\207\n\013\201 \210\003\b\255\t\205\013\n\n\013\201 \203\002\203\003\002\ \013)10.1(\t)10(\b\255\002 \004\013\016)36(\220\007\205\b\006\005)-10(: )]TJ -0.048 Tc 0.048 Tw T* [(h)-55(t)-83.3(t)-63(p)-31.9(:)-24.7(/)118.7(/)46.6(e)-56.6(l)-53.9(i)-53.7(b)-56.1(r)-47.5(a)-54.5(r)-93.4(y.)-52(r)-64.4(u/)]TJ 1 0.68 0 0.12 k /GS1 gs /T1_2 1 Tf 0 Tc 0.023 Tw 0 -1.767 TD [(\004\024\003\034\024\033)-23(\024\003\034\002\002\001 \033\034\031\035\034\024\032\035\201:)]TJ 0 0 0 1 k /GS0 gs /T1_0 1 Tf 0 -1.2 TD [(\033\211\203\220\255)20(\013\200 \034.\021)83(.)]TJ T* [(E-mail: pr)24(octologia@mail.ru)]TJ 1 0.68 0 0.12 k /GS1 gs /T1_2 1 Tf 0 -1.767 TD [(\215\032\003. \035\034\036\032\031\030\027\034 \027 \003\001\217\021)23(\033\031\032\220\235\027 \035\034\036\032\031\024\240\035:)]TJ 0 0 0 1 k /GS0 gs /T1_0 1 Tf 0 -1.2 TD (\f\013\003\002\255\220\205\004\013\200\220 \034.\034.)Tj T* [(\024)50(\b\003.: \(4)25(99\) 1)112(99-00-68)]TJ 26.362 27.968 Td [(\212)22(\005\205\n\220\003 \220\205\b\213\002\006\t\205\002\205\013\200\220\n \202\ \b\007\b\205\220\003\214\n\013\201 \006\003\005\206\203\013\201 )]TJ T* (\004\013 \n\220\007\013\205\005 \200 \006\202\b\205\b \006\200\235\002\ , \002\n\202\013\205\215\220\001\002\013\n\n\211\216 )Tj T* [(\t)10(\b\216\n\013\003\013\213\002\201 \002 \215\220\006\006)11(\013\200\211\216 \255)20(\013\215\215\005\n\002\255\220\001\002\201)]TJ 1 0.68 0 0.12 k /GS1 gs /T1_2 1 Tf 0 -1.767 TD [(\n)10(\034\255\027\033)-23(\024\035\032\030\027\240\002\002\240\034 \021\036\240\033)-23(\024\240\003\034\035\034\002\027\034)]TJ 0 0 0 1 k /GS0 gs /T1_0 1 Tf 0 -1.2 TD [(\f\031 \217\016)-23.2(7)12.9(7-1)125.1(409)37(7)]TJ /T1_2 1 Tf 0 -1.767 TD [(\200\240\036\217\027\033\002\240 \027\002\036\034\031)12(\033: )]TJ 0 -1.2 TD [(\037\004 \253\200\240\020\024\032 \n)20(\240\033\033\027\027\273\026)-23.3(\227 \200\2007)80(1)104(5)]TJ T* [(\004\004\004 \253\013)60.1(\035\032\023)-58(-\200\035\034\033\033 \004\031\035\021\255)]TJ 0 Tw (\273)Tj 0.023 Tw [(\026)-23.3(\227 809)23(7)34(8)]TJ /T1_0 1 Tf T* [(\007)-30(\003\235 \002\n\007\002\200\002\007\005\220\003\214\n\211\216 \004\013\007\ \004\002\006\207\002\255)20.1(\013\200)]TJ /T1_2 1 Tf 0 -1.767 TD [(\f)27(\021\035\002\032\023 \027\002\036\034\031)12(\033\027\035\021\034\024\033\022:)]TJ /T1_0 1 Tf -0.233 Tw 0 -1.2 TD (\227)Tj /Span<>> BDC [( )-500( )]TJ EMC (SCOPUS)Tj 0.023 Tw T* (\227)Tj /Span<>> BDC [( )-244( )]TJ EMC 1.3 0 Td [(\033)20(\013\006\006\002\201\006\255\002\201 \002\n\007\b\255)21(\006 \n\220\005)10(\207\n\013\213)21(\013 \001\002\t\002\205\013\200\220\n\002\235 \(\033\031\022\017\))]TJ -1.3 -1.2 Td (\227)Tj /Span<>> BDC [( )-244( )]TJ EMC 1.3 0 Td [(R)21(ussian Science Citation Index \(RSCI\) )]TJ 0 Tw ( )Tj 0.023 Tw T* [(\n\220\016)-23.3(\004\003\220\t)10.1(\202\013\205\215\b W)41(eb of Science)]TJ 0.011 Tw -1.3 -1.767 Td [(\f\205\002 \205\220\215\b\221\b\n\002\002 \205\b\255)-10.9(\003\220\215\211 \205\b\007\220\255\001\002\235 \205\005\255)20(\013\200\013\007\006\t\200\005\b\t)10.1(\006\235 )]TJ 0.023 Tw T* [(\205\b\255)-11(\003\220\215\n\013\201 \004\013\003\002\t\002\255)20.1(\013\201)]TJ 9 0 0 9 306.1417 146.5369 Tm [(\f\013\007\004\002\006\220\n\013 \200\016)-23.3(\004\b\207\220\t\214 1)137(3.02.2)25(02)50(4)]TJ 0 Tw ( )Tj 0.023 Tw 0 -1.333 TD [(\024)50(\002\205\220\206 1)63(000 \210\255)21(. \020\220\255\220 \217\016)-23.2(1)63(0)]TJ 0 Tw ( )Tj 0.023 Tw 0 -1.333 TD [(\037\t\004\b\207\220\t)13.1(\220\n\013 \200\016)-23.3(\031\f \034\205\222\013\200 \031.\026.)]TJ 0 Tw ( )Tj 0.023 Tw 0 -1.333 TD [(\240\013\006\255\200\220, \026\200\002\220\215\013)10(\t)10(\013\205\n\220\235 \005)10(\003\002\001\220, \007. 59)]TJ 0 -1.963 TD [(\031\n\202\013\205\215\220\001\002\235 \013 \006\t)10(\013\002\215\013\006\t\002 \210\255)21(.\016)-23.2(\227 \253\032\200\013\203\013\007\n\220\235 \001\b\n\220\273)]TJ ET /GS1 gs q 1 0 0 1 283.4646 408.189 cm 0 0 m 0 -317.48 l S Q BT 1 0.68 0 0.12 k /T1_0 1 Tf 0.01 Tc -0.243 Tw 13.3 0 0 14 129.1146 485.8571 Tm (\022\026)Tj /Span<>> BDC 1.262 0 Td ( )Tj EMC (\223\224)Tj /Span<>> BDC ( )Tj EMC [(\022\037)5(\225)5(\f\033)48(\026\027)]TJ /Span<>> BDC 5.264 0 Td ( )Tj EMC (\024\031)Tj /Span<>> BDC ( )Tj EMC (\224\034)Tj /Span<>> BDC ( )Tj EMC [(\032\027\031\030)5( )-237.9(\240\034)]TJ /Span<>> BDC ( )Tj EMC (\226\031)Tj /Span<>> BDC ( )Tj EMC (\017\031\022)Tj /Span<>> BDC ( )Tj EMC [(\032\027\031\030)5( )-237.9(\212\223\033)]TJ /Span<>> BDC ( )Tj EMC [(\022\026)-10(\r)]TJ 0 Tc 0 Tw 13.3 0 0 14 437.8809 485.8571 Tm ( )Tj 0.01 Tc -0.005 Tw 13.3 0 0 14 119.4323 470.4572 Tm [(\037\036\035\034\033\037\032\032\031\030\032\027)42(\037\030)5( \037\036\035\034\032\024\023\034\022\022\037\030)5( \037\033\021)80(\026\022\031\020)21.1(\026\017\031\031)]TJ 0 Tc 0 Tw 13.3 0 0 14 447.5632 470.4572 Tm ( )Tj 13.3 0 0 14 141.1628 455.0572 Tm (\253)Tj -0.233 Tw [(\026)21(\032)]TJ /Span<>> BDC ( )Tj EMC (\032\037)Tj /Span<>> BDC ( )Tj EMC (\017\031)Tj /Span<>> BDC ( )Tj EMC [(\026\017\031\025 )-233(\027)42(\037)]TJ /Span<>> BDC ( )Tj EMC (\r\037)Tj /Span<>> BDC ( )Tj EMC (\f\033\037\027)Tj /Span<>> BDC 12.456 0 Td ( )Tj EMC [(\024)35(\037)]TJ /Span<>> BDC ( )Tj EMC (\r\037)Tj /Span<>> BDC ( )Tj EMC [(\021)35(\037\023 )-233(\033\037\032)]TJ /Span<>> BDC ( )Tj EMC (\032\031\031\273)Tj 0 0 0 1 k /GS0 gs 12 0 0 12 149.7171 438.2225 Tm (\023\211)Tj /Span<>> BDC ( )Tj EMC (\216\013)Tj /Span<>> BDC ( )Tj EMC [(\007\002\t )-256.3(\013\007\002\n )-256.2(\205\220 )-256.2(\200\016)-23.3(\t\205\002 )-256.3(\215\b)]TJ /Span<>> BDC ( )Tj EMC (\006\235)Tj /Span<>> BDC ( )Tj EMC [(\001\220. )-256.3(\037\006)]TJ /Span<>> BDC ( )Tj EMC (\n\013)Tj /Span<>> BDC ( )Tj EMC [(\200\220\n )-256.2(\200\016)-23.3(2)25(002 )-256.3(\213)21(\013)]TJ /Span<>> BDC ( )Tj EMC [(\007\005)52(.)]TJ ET endstream endobj 2730 0 obj <> endobj 2731 0 obj <> endobj 2742 0 obj <>stream Adobe Illustrator CS6 (Windows) 2021-03-20T11:36:26+06:00 2021-03-20T11:36:26+05:00 2021-03-20T11:36:26+05:00 1 False True 44.283602 32.991785 Millimeters Black Default Swatch Group 0 application/pdf logo_rus xmp.did:572411794689EB119856D7C1468A9BFF uuid:aeef018f-0eed-432a-b785-50521f8e4030 xmp.did:877d3e89-8f6e-3147-a3da-4e72d0a73d9c proof:pdf converted from application/postscript to application/vnd.adobe.illustrator saved xmp.iid:877d3e89-8f6e-3147-a3da-4e72d0a73d9c 2019-04-10T11:26:07+03:00 Adobe Illustrator CC 2015 (Windows) / saved xmp.iid:572411794689EB119856D7C1468A9BFF 2021-03-20T11:36:23+05:00 Adobe Illustrator CS6 (Windows) / uuid:294c243b-30be-41b6-a8ff-47875a991f70 xmp.did:877d3e89-8f6e-3147-a3da-4e72d0a73d9c xmp.did:877d3e89-8f6e-3147-a3da-4e72d0a73d9c proof:pdf Document Adobe PDF library 10.01 endstream endobj 2741 0 obj <>stream Adobe Graphics Manager 2021-04-12T11:52:16+05:00 2021-04-12T11:52:16+05:00 Acrobat Distiller 10.1.16 (Windows) CCBYv40_logo.ai densen endstream endobj 6 0 obj <> endobj 2743 0 obj <> endobj xref 0 2744 0000000000 65535 f 0000000016 00000 n 0000000124 00000 n 0000003050 00000 n 0000000000 00000 f 0000003018 00000 n 0008583403 00000 n 0000003143 00000 n 0000003237 00000 n 0000003331 00000 n 0000003425 00000 n 0000003520 00000 n 0000003615 00000 n 0000003710 00000 n 0007771302 00000 n 0007771406 00000 n 0007771510 00000 n 0007771614 00000 n 0007771718 00000 n 0006771583 00000 n 0006771687 00000 n 0006771791 00000 n 0006771895 00000 n 0006771999 00000 n 0005321613 00000 n 0005321717 00000 n 0005321821 00000 n 0005321925 00000 n 0005322029 00000 n 0003842483 00000 n 0003842588 00000 n 0003842693 00000 n 0003842798 00000 n 0003842903 00000 n 0002764638 00000 n 0002764743 00000 n 0002764848 00000 n 0002764953 00000 n 0002765058 00000 n 0001428003 00000 n 0001428103 00000 n 0001428203 00000 n 0001428303 00000 n 0001428403 00000 n 0000003819 00000 n 0000003914 00000 n 0000004009 00000 n 0000004104 00000 n 0000004199 00000 n 0000004294 00000 n 0000004389 00000 n 0001280150 00000 n 0001280543 00000 n 0001281037 00000 n 0001281441 00000 n 0001281832 00000 n 0001121976 00000 n 0001122367 00000 n 0001122759 00000 n 0001123150 00000 n 0001123556 00000 n 0000994700 00000 n 0000995093 00000 n 0000995587 00000 n 0000995990 00000 n 0000996381 00000 n 0000848335 00000 n 0000848714 00000 n 0000849092 00000 n 0000849496 00000 n 0000849915 00000 n 0000568527 00000 n 0000568920 00000 n 0000569414 00000 n 0000569817 00000 n 0000570261 00000 n 0000366741 00000 n 0000367245 00000 n 0000367750 00000 n 0000368128 00000 n 0000368547 00000 n 0000004505 00000 n 0000004996 00000 n 0000005399 00000 n 0000005834 00000 n 0000006338 00000 n 0000006795 00000 n 0000007199 00000 n 0000007618 00000 n 0000317920 00000 n 0000317946 00000 n 0000357428 00000 n 0000023020 00000 n 0000023133 00000 n 0000010369 00000 n 0000050371 00000 n 0000307562 00000 n 0000047599 00000 n 0000051300 00000 n 0000358190 00000 n 0000357239 00000 n 0000047312 00000 n 0000351336 00000 n 0000287937 00000 n 0000049443 00000 n 0000150351 00000 n 0000228669 00000 n 0000287824 00000 n 0000048656 00000 n 0000255461 00000 n 0000180649 00000 n 0000226168 00000 n 0000223837 00000 n 0000221497 00000 n 0000219165 00000 n 0000185421 00000 n 0000194473 00000 n 0000202871 00000 n 0000211193 00000 n 0000150641 00000 n 0000178329 00000 n 0000171036 00000 n 0000126077 00000 n 0000023244 00000 n 0000023455 00000 n 0000007936 00000 n 0000011207 00000 n 0000011846 00000 n 0000012992 00000 n 0000013939 00000 n 0000120678 00000 n 0000120817 00000 n 0000120956 00000 n 0000121095 00000 n 0000121234 00000 n 0000121373 00000 n 0000121512 00000 n 0000121651 00000 n 0000121790 00000 n 0000121929 00000 n 0000122068 00000 n 0000122206 00000 n 0000122345 00000 n 0000122484 00000 n 0000122622 00000 n 0000122761 00000 n 0000122900 00000 n 0000123039 00000 n 0000123178 00000 n 0000123317 00000 n 0000123456 00000 n 0000123595 00000 n 0000123734 00000 n 0000123873 00000 n 0000099153 00000 n 0000099929 00000 n 0000101425 00000 n 0000083782 00000 n 0000084393 00000 n 0000085430 00000 n 0000072328 00000 n 0000072958 00000 n 0000074076 00000 n 0000053267 00000 n 0000053950 00000 n 0000055219 00000 n 0000051525 00000 n 0000051856 00000 n 0000052203 00000 n 0000056240 00000 n 0000075025 00000 n 0000086331 00000 n 0000102574 00000 n 0000125997 00000 n 0000125917 00000 n 0000125831 00000 n 0000125737 00000 n 0000125655 00000 n 0000125575 00000 n 0000125495 00000 n 0000125415 00000 n 0000125328 00000 n 0000125241 00000 n 0000125155 00000 n 0000125068 00000 n 0000124981 00000 n 0000124894 00000 n 0000124804 00000 n 0000124717 00000 n 0000124630 00000 n 0000124540 00000 n 0000124460 00000 n 0000124380 00000 n 0000124292 00000 n 0000124196 00000 n 0000124100 00000 n 0000124012 00000 n 0000178379 00000 n 0000180325 00000 n 0000226219 00000 n 0000223887 00000 n 0000221547 00000 n 0000219215 00000 n 0000221161 00000 n 0000223493 00000 n 0000225824 00000 n 0000228165 00000 n 0000285878 00000 n 0000308235 00000 n 0000308723 00000 n 0000309462 00000 n 0000310088 00000 n 0000366446 00000 n 0000355933 00000 n 0000355972 00000 n 0000357490 00000 n 0000357663 00000 n 0000358052 00000 n 0000357587 00000 n 0000358107 00000 n 0000358228 00000 n 0000366584 00000 n 0000496462 00000 n 0000565666 00000 n 0000562773 00000 n 0000559856 00000 n 0000556971 00000 n 0000499638 00000 n 0000516580 00000 n 0000528374 00000 n 0000544359 00000 n 0000436860 00000 n 0000493497 00000 n 0000490584 00000 n 0000487759 00000 n 0000449289 00000 n 0000464706 00000 n 0000477892 00000 n 0000411631 00000 n 0000387299 00000 n 0000387342 00000 n 0000368940 00000 n 0000368983 00000 n 0000386594 00000 n 0000386733 00000 n 0000386872 00000 n 0000387203 00000 n 0000387107 00000 n 0000387011 00000 n 0000410925 00000 n 0000411063 00000 n 0000411202 00000 n 0000411535 00000 n 0000411438 00000 n 0000411341 00000 n 0000493548 00000 n 0000490635 00000 n 0000487810 00000 n 0000489756 00000 n 0000492581 00000 n 0000495494 00000 n 0000565717 00000 n 0000562824 00000 n 0000559907 00000 n 0000557022 00000 n 0000558968 00000 n 0000561853 00000 n 0000564770 00000 n 0000567663 00000 n 0000830601 00000 n 0000830764 00000 n 0000783043 00000 n 0000783070 00000 n 0000822050 00000 n 0000816136 00000 n 0000759749 00000 n 0000724993 00000 n 0000753436 00000 n 0000748402 00000 n 0000570695 00000 n 0000599833 00000 n 0000723047 00000 n 0000748441 00000 n 0000754036 00000 n 0000754482 00000 n 0000755115 00000 n 0000830307 00000 n 0000820744 00000 n 0000820783 00000 n 0000822089 00000 n 0000830444 00000 n 0000844273 00000 n 0000844411 00000 n 0000844549 00000 n 0000844688 00000 n 0000844827 00000 n 0000844966 00000 n 0000845104 00000 n 0000845242 00000 n 0000845380 00000 n 0000845519 00000 n 0000845658 00000 n 0000845797 00000 n 0000845936 00000 n 0000846075 00000 n 0000846214 00000 n 0000846353 00000 n 0000846491 00000 n 0000846630 00000 n 0000848254 00000 n 0000848173 00000 n 0000848090 00000 n 0000848004 00000 n 0000847918 00000 n 0000847836 00000 n 0000847758 00000 n 0000847670 00000 n 0000847564 00000 n 0000847482 00000 n 0000847392 00000 n 0000847304 00000 n 0000847217 00000 n 0000847124 00000 n 0000847031 00000 n 0000846943 00000 n 0000846856 00000 n 0000846769 00000 n 0000970789 00000 n 0000945705 00000 n 0000922036 00000 n 0000892541 00000 n 0000892696 00000 n 0000850308 00000 n 0000850679 00000 n 0000882571 00000 n 0000882710 00000 n 0000882848 00000 n 0000882987 00000 n 0000883126 00000 n 0000883265 00000 n 0000883403 00000 n 0000883542 00000 n 0000883681 00000 n 0000883820 00000 n 0000883959 00000 n 0000884098 00000 n 0000884236 00000 n 0000884375 00000 n 0000884514 00000 n 0000884653 00000 n 0000884792 00000 n 0000884931 00000 n 0000885070 00000 n 0000885209 00000 n 0000885348 00000 n 0000885487 00000 n 0000885626 00000 n 0000885765 00000 n 0000885904 00000 n 0000886043 00000 n 0000886182 00000 n 0000886321 00000 n 0000886460 00000 n 0000886599 00000 n 0000886738 00000 n 0000886877 00000 n 0000887016 00000 n 0000887155 00000 n 0000887293 00000 n 0000887432 00000 n 0000887571 00000 n 0000887710 00000 n 0000887849 00000 n 0000887988 00000 n 0000888126 00000 n 0000888265 00000 n 0000888404 00000 n 0000888542 00000 n 0000892454 00000 n 0000892374 00000 n 0000892290 00000 n 0000892206 00000 n 0000892119 00000 n 0000892032 00000 n 0000891951 00000 n 0000891870 00000 n 0000891785 00000 n 0000891700 00000 n 0000891615 00000 n 0000891536 00000 n 0000891457 00000 n 0000891378 00000 n 0000891294 00000 n 0000891205 00000 n 0000891116 00000 n 0000891031 00000 n 0000890902 00000 n 0000890773 00000 n 0000890684 00000 n 0000890605 00000 n 0000890515 00000 n 0000890431 00000 n 0000890341 00000 n 0000890251 00000 n 0000890168 00000 n 0000890078 00000 n 0000889999 00000 n 0000889918 00000 n 0000889831 00000 n 0000889745 00000 n 0000889663 00000 n 0000889572 00000 n 0000889481 00000 n 0000889394 00000 n 0000889307 00000 n 0000889227 00000 n 0000889132 00000 n 0000889037 00000 n 0000888945 00000 n 0000888863 00000 n 0000888772 00000 n 0000888681 00000 n 0000918210 00000 n 0000918349 00000 n 0000918488 00000 n 0000918626 00000 n 0000918765 00000 n 0000918903 00000 n 0000919042 00000 n 0000919181 00000 n 0000919320 00000 n 0000919459 00000 n 0000919597 00000 n 0000919736 00000 n 0000919875 00000 n 0000920014 00000 n 0000920153 00000 n 0000920292 00000 n 0000920431 00000 n 0000921956 00000 n 0000921870 00000 n 0000921791 00000 n 0000921701 00000 n 0000921614 00000 n 0000921532 00000 n 0000921444 00000 n 0000921356 00000 n 0000921277 00000 n 0000921183 00000 n 0000921101 00000 n 0000921011 00000 n 0000920921 00000 n 0000920831 00000 n 0000920748 00000 n 0000920660 00000 n 0000920570 00000 n 0001110438 00000 n 0001110553 00000 n 0001067802 00000 n 0001067829 00000 n 0001101887 00000 n 0001045280 00000 n 0001021454 00000 n 0000996759 00000 n 0001110144 00000 n 0001101926 00000 n 0001110281 00000 n 0001119303 00000 n 0001119442 00000 n 0001119581 00000 n 0001119719 00000 n 0001119857 00000 n 0001119996 00000 n 0001120135 00000 n 0001120274 00000 n 0001120412 00000 n 0001120550 00000 n 0001120689 00000 n 0001120828 00000 n 0001121897 00000 n 0001121818 00000 n 0001121739 00000 n 0001121648 00000 n 0001121557 00000 n 0001121477 00000 n 0001121398 00000 n 0001121308 00000 n 0001121228 00000 n 0001121146 00000 n 0001121060 00000 n 0001120967 00000 n 0001254306 00000 n 0001231064 00000 n 0001208689 00000 n 0001166517 00000 n 0001166864 00000 n 0001123949 00000 n 0001124312 00000 n 0001156821 00000 n 0001156960 00000 n 0001157099 00000 n 0001157237 00000 n 0001157376 00000 n 0001157515 00000 n 0001157654 00000 n 0001157793 00000 n 0001157930 00000 n 0001158069 00000 n 0001158208 00000 n 0001158347 00000 n 0001158486 00000 n 0001158625 00000 n 0001158764 00000 n 0001158903 00000 n 0001159042 00000 n 0001159181 00000 n 0001159320 00000 n 0001159458 00000 n 0001159596 00000 n 0001159734 00000 n 0001159873 00000 n 0001160011 00000 n 0001160150 00000 n 0001160289 00000 n 0001160428 00000 n 0001160566 00000 n 0001160705 00000 n 0001160844 00000 n 0001160983 00000 n 0001161122 00000 n 0001161261 00000 n 0001161400 00000 n 0001161539 00000 n 0001161678 00000 n 0001161817 00000 n 0001161956 00000 n 0001162095 00000 n 0001162234 00000 n 0001162373 00000 n 0001162512 00000 n 0001162651 00000 n 0001166430 00000 n 0001166343 00000 n 0001166256 00000 n 0001166162 00000 n 0001166081 00000 n 0001165991 00000 n 0001165901 00000 n 0001165820 00000 n 0001165741 00000 n 0001165662 00000 n 0001165579 00000 n 0001165496 00000 n 0001165406 00000 n 0001165324 00000 n 0001165242 00000 n 0001165163 00000 n 0001165083 00000 n 0001164996 00000 n 0001164903 00000 n 0001164816 00000 n 0001164737 00000 n 0001164649 00000 n 0001164564 00000 n 0001164471 00000 n 0001164384 00000 n 0001164297 00000 n 0001164207 00000 n 0001164117 00000 n 0001164027 00000 n 0001163937 00000 n 0001163846 00000 n 0001163755 00000 n 0001163670 00000 n 0001163585 00000 n 0001163498 00000 n 0001163408 00000 n 0001163319 00000 n 0001163231 00000 n 0001163144 00000 n 0001163057 00000 n 0001162972 00000 n 0001162881 00000 n 0001162790 00000 n 0001199389 00000 n 0001199528 00000 n 0001199667 00000 n 0001199806 00000 n 0001199945 00000 n 0001200084 00000 n 0001200223 00000 n 0001200362 00000 n 0001200501 00000 n 0001200640 00000 n 0001200779 00000 n 0001200918 00000 n 0001201057 00000 n 0001201196 00000 n 0001201335 00000 n 0001201474 00000 n 0001201613 00000 n 0001201751 00000 n 0001201890 00000 n 0001202029 00000 n 0001202168 00000 n 0001202306 00000 n 0001202445 00000 n 0001202584 00000 n 0001202723 00000 n 0001202862 00000 n 0001203001 00000 n 0001203138 00000 n 0001203277 00000 n 0001203416 00000 n 0001203555 00000 n 0001203694 00000 n 0001203833 00000 n 0001203972 00000 n 0001204109 00000 n 0001204248 00000 n 0001204387 00000 n 0001204526 00000 n 0001204665 00000 n 0001204804 00000 n 0001204943 00000 n 0001208593 00000 n 0001208497 00000 n 0001208401 00000 n 0001208305 00000 n 0001208209 00000 n 0001208116 00000 n 0001208026 00000 n 0001207945 00000 n 0001207866 00000 n 0001207770 00000 n 0001207674 00000 n 0001207578 00000 n 0001207482 00000 n 0001207386 00000 n 0001207290 00000 n 0001207207 00000 n 0001207123 00000 n 0001207039 00000 n 0001206946 00000 n 0001206856 00000 n 0001206779 00000 n 0001206698 00000 n 0001206612 00000 n 0001206531 00000 n 0001206454 00000 n 0001206364 00000 n 0001206274 00000 n 0001206178 00000 n 0001206101 00000 n 0001206013 00000 n 0001205934 00000 n 0001205850 00000 n 0001205766 00000 n 0001205685 00000 n 0001205608 00000 n 0001205518 00000 n 0001205434 00000 n 0001205346 00000 n 0001205256 00000 n 0001205169 00000 n 0001205082 00000 n 0001395020 00000 n 0001395319 00000 n 0001353568 00000 n 0001353595 00000 n 0001386469 00000 n 0001331072 00000 n 0001306990 00000 n 0001282223 00000 n 0001394726 00000 n 0001386508 00000 n 0001394863 00000 n 0001420110 00000 n 0001420248 00000 n 0001420387 00000 n 0001420526 00000 n 0001420665 00000 n 0001420803 00000 n 0001420941 00000 n 0001421080 00000 n 0001421219 00000 n 0001421358 00000 n 0001421497 00000 n 0001421635 00000 n 0001421773 00000 n 0001421912 00000 n 0001422050 00000 n 0001422189 00000 n 0001422328 00000 n 0001422466 00000 n 0001422605 00000 n 0001422744 00000 n 0001422883 00000 n 0001423022 00000 n 0001423161 00000 n 0001423300 00000 n 0001423439 00000 n 0001423578 00000 n 0001423717 00000 n 0001423856 00000 n 0001423995 00000 n 0001424134 00000 n 0001424273 00000 n 0001424412 00000 n 0001424549 00000 n 0001424688 00000 n 0001424827 00000 n 0001427918 00000 n 0001427833 00000 n 0001427746 00000 n 0001427659 00000 n 0001427574 00000 n 0001427488 00000 n 0001427407 00000 n 0001427328 00000 n 0001427233 00000 n 0001427138 00000 n 0001427059 00000 n 0001426969 00000 n 0001426879 00000 n 0001426799 00000 n 0001426719 00000 n 0001426635 00000 n 0001426552 00000 n 0001426469 00000 n 0001426388 00000 n 0001426301 00000 n 0001426214 00000 n 0001426129 00000 n 0001426044 00000 n 0001425957 00000 n 0001425870 00000 n 0001425789 00000 n 0001425694 00000 n 0001425599 00000 n 0001425504 00000 n 0001425408 00000 n 0001425312 00000 n 0001425222 00000 n 0001425141 00000 n 0001425050 00000 n 0001424966 00000 n 0002611758 00000 n 0002612164 00000 n 0002612586 00000 n 0002612995 00000 n 0002613493 00000 n 0002350725 00000 n 0002351160 00000 n 0002351596 00000 n 0002352013 00000 n 0002352434 00000 n 0001846033 00000 n 0001846541 00000 n 0001846965 00000 n 0001847401 00000 n 0001847860 00000 n 0001572336 00000 n 0001572743 00000 n 0001573251 00000 n 0001573668 00000 n 0001574072 00000 n 0001428503 00000 n 0001428883 00000 n 0001429275 00000 n 0001429679 00000 n 0001430099 00000 n 0001549220 00000 n 0001526644 00000 n 0001502933 00000 n 0001472429 00000 n 0001472616 00000 n 0001430493 00000 n 0001430880 00000 n 0001462051 00000 n 0001462190 00000 n 0001462329 00000 n 0001462467 00000 n 0001462606 00000 n 0001462745 00000 n 0001462884 00000 n 0001463023 00000 n 0001463162 00000 n 0001463300 00000 n 0001463439 00000 n 0001463577 00000 n 0001463716 00000 n 0001463855 00000 n 0001463993 00000 n 0001464131 00000 n 0001464270 00000 n 0001464409 00000 n 0001464548 00000 n 0001464687 00000 n 0001464826 00000 n 0001464965 00000 n 0001465104 00000 n 0001465243 00000 n 0001465382 00000 n 0001465521 00000 n 0001465660 00000 n 0001465799 00000 n 0001465938 00000 n 0001466077 00000 n 0001466216 00000 n 0001466355 00000 n 0001466494 00000 n 0001466633 00000 n 0001466772 00000 n 0001466911 00000 n 0001467050 00000 n 0001467188 00000 n 0001467327 00000 n 0001467466 00000 n 0001467605 00000 n 0001467744 00000 n 0001467883 00000 n 0001468022 00000 n 0001468161 00000 n 0001468300 00000 n 0001472333 00000 n 0001472237 00000 n 0001472158 00000 n 0001472074 00000 n 0001471990 00000 n 0001471896 00000 n 0001471802 00000 n 0001471720 00000 n 0001471628 00000 n 0001471548 00000 n 0001471461 00000 n 0001471376 00000 n 0001471288 00000 n 0001471196 00000 n 0001471120 00000 n 0001471032 00000 n 0001470947 00000 n 0001470865 00000 n 0001470778 00000 n 0001470685 00000 n 0001470595 00000 n 0001470505 00000 n 0001470424 00000 n 0001470343 00000 n 0001470261 00000 n 0001470177 00000 n 0001470083 00000 n 0001469998 00000 n 0001469904 00000 n 0001469819 00000 n 0001469734 00000 n 0001469644 00000 n 0001469554 00000 n 0001469471 00000 n 0001469384 00000 n 0001469297 00000 n 0001469213 00000 n 0001469129 00000 n 0001469046 00000 n 0001468961 00000 n 0001468876 00000 n 0001468789 00000 n 0001468701 00000 n 0001468621 00000 n 0001468530 00000 n 0001468439 00000 n 0001498159 00000 n 0001498296 00000 n 0001498435 00000 n 0001498573 00000 n 0001498712 00000 n 0001498851 00000 n 0001498990 00000 n 0001499129 00000 n 0001499268 00000 n 0001499406 00000 n 0001499544 00000 n 0001499683 00000 n 0001499821 00000 n 0001499960 00000 n 0001500098 00000 n 0001500236 00000 n 0001500375 00000 n 0001500514 00000 n 0001500653 00000 n 0001500791 00000 n 0001500930 00000 n 0001502846 00000 n 0001502761 00000 n 0001502679 00000 n 0001502597 00000 n 0001502503 00000 n 0001502416 00000 n 0001502335 00000 n 0001502248 00000 n 0001502160 00000 n 0001502072 00000 n 0001501976 00000 n 0001501880 00000 n 0001501784 00000 n 0001501688 00000 n 0001501602 00000 n 0001501512 00000 n 0001501424 00000 n 0001501334 00000 n 0001501246 00000 n 0001501167 00000 n 0001501069 00000 n 0001826531 00000 n 0001826678 00000 n 0001772648 00000 n 0001772675 00000 n 0001815520 00000 n 0001807263 00000 n 0001750441 00000 n 0001727392 00000 n 0001574519 00000 n 0001586413 00000 n 0001640019 00000 n 0001725446 00000 n 0001723500 00000 n 0001826237 00000 n 0001807302 00000 n 0001816398 00000 n 0001816987 00000 n 0001817969 00000 n 0001818852 00000 n 0001826374 00000 n 0001842435 00000 n 0001842574 00000 n 0001842713 00000 n 0001842852 00000 n 0001842991 00000 n 0001843130 00000 n 0001843269 00000 n 0001843408 00000 n 0001843547 00000 n 0001843686 00000 n 0001843825 00000 n 0001843964 00000 n 0001844103 00000 n 0001844242 00000 n 0001844381 00000 n 0001844520 00000 n 0001845943 00000 n 0001845854 00000 n 0001845765 00000 n 0001845678 00000 n 0001845594 00000 n 0001845514 00000 n 0001845426 00000 n 0001845346 00000 n 0001845256 00000 n 0001845167 00000 n 0001845078 00000 n 0001844991 00000 n 0001844907 00000 n 0001844827 00000 n 0001844739 00000 n 0001844659 00000 n 0002307663 00000 n 0002307690 00000 n 0002342174 00000 n 0002217091 00000 n 0002235955 00000 n 0002116427 00000 n 0002131974 00000 n 0002179458 00000 n 0001868241 00000 n 0001875669 00000 n 0001907036 00000 n 0001948778 00000 n 0001992084 00000 n 0002048898 00000 n 0001848265 00000 n 0002114092 00000 n 0002112146 00000 n 0002110097 00000 n 0002108048 00000 n 0002105999 00000 n 0002214769 00000 n 0002212733 00000 n 0002305328 00000 n 0002350431 00000 n 0002342213 00000 n 0002350568 00000 n 0002500152 00000 n 0002512536 00000 n 0002537536 00000 n 0002570906 00000 n 0002423803 00000 n 0002438065 00000 n 0002467488 00000 n 0002394464 00000 n 0002362065 00000 n 0002362336 00000 n 0002352830 00000 n 0002352931 00000 n 0002359988 00000 n 0002360129 00000 n 0002360270 00000 n 0002360411 00000 n 0002360551 00000 n 0002360691 00000 n 0002360832 00000 n 0002360971 00000 n 0002361112 00000 n 0002361978 00000 n 0002361881 00000 n 0002361782 00000 n 0002361694 00000 n 0002361605 00000 n 0002361521 00000 n 0002361437 00000 n 0002361345 00000 n 0002361253 00000 n 0002387966 00000 n 0002388107 00000 n 0002388247 00000 n 0002388388 00000 n 0002388529 00000 n 0002388669 00000 n 0002388810 00000 n 0002388951 00000 n 0002389091 00000 n 0002389232 00000 n 0002389373 00000 n 0002389514 00000 n 0002389655 00000 n 0002389796 00000 n 0002389937 00000 n 0002390078 00000 n 0002390219 00000 n 0002390360 00000 n 0002390501 00000 n 0002390642 00000 n 0002390782 00000 n 0002390923 00000 n 0002391064 00000 n 0002391204 00000 n 0002391345 00000 n 0002391486 00000 n 0002391627 00000 n 0002391768 00000 n 0002394373 00000 n 0002394290 00000 n 0002394192 00000 n 0002394094 00000 n 0002394004 00000 n 0002393915 00000 n 0002393817 00000 n 0002393728 00000 n 0002393641 00000 n 0002393554 00000 n 0002393457 00000 n 0002393360 00000 n 0002393261 00000 n 0002393173 00000 n 0002393084 00000 n 0002393000 00000 n 0002392916 00000 n 0002392824 00000 n 0002392732 00000 n 0002392641 00000 n 0002392558 00000 n 0002392460 00000 n 0002392362 00000 n 0002392272 00000 n 0002392183 00000 n 0002392085 00000 n 0002391996 00000 n 0002391909 00000 n 0002498205 00000 n 0002496258 00000 n 0002609708 00000 n 0002607761 00000 n 0002605814 00000 n 0002740179 00000 n 0002709664 00000 n 0002709810 00000 n 0002680431 00000 n 0002680640 00000 n 0002636160 00000 n 0002636189 00000 n 0002671873 00000 n 0002613898 00000 n 0002680133 00000 n 0002671914 00000 n 0002680273 00000 n 0002704841 00000 n 0002704982 00000 n 0002705121 00000 n 0002705262 00000 n 0002705403 00000 n 0002705544 00000 n 0002705685 00000 n 0002705826 00000 n 0002705967 00000 n 0002706108 00000 n 0002706249 00000 n 0002706389 00000 n 0002706530 00000 n 0002706671 00000 n 0002706812 00000 n 0002706953 00000 n 0002707094 00000 n 0002707235 00000 n 0002707376 00000 n 0002707517 00000 n 0002707658 00000 n 0002709582 00000 n 0002709491 00000 n 0002709394 00000 n 0002709306 00000 n 0002709229 00000 n 0002709138 00000 n 0002709053 00000 n 0002708973 00000 n 0002708877 00000 n 0002708786 00000 n 0002708695 00000 n 0002708592 00000 n 0002708502 00000 n 0002708412 00000 n 0002708326 00000 n 0002708238 00000 n 0002708157 00000 n 0002708075 00000 n 0002707984 00000 n 0002707887 00000 n 0002707799 00000 n 0002736962 00000 n 0002737103 00000 n 0002737244 00000 n 0002737385 00000 n 0002737526 00000 n 0002737667 00000 n 0002737808 00000 n 0002737949 00000 n 0002738090 00000 n 0002738230 00000 n 0002738371 00000 n 0002738511 00000 n 0002738652 00000 n 0002738793 00000 n 0002740102 00000 n 0002740011 00000 n 0002739926 00000 n 0002739846 00000 n 0002739750 00000 n 0002739654 00000 n 0002739563 00000 n 0002739472 00000 n 0002739369 00000 n 0002739279 00000 n 0002739189 00000 n 0002739103 00000 n 0002739015 00000 n 0002738934 00000 n 0003715590 00000 n 0003715996 00000 n 0003716365 00000 n 0003716734 00000 n 0003717116 00000 n 0003568286 00000 n 0003568709 00000 n 0003569106 00000 n 0003569605 00000 n 0003570011 00000 n 0003312290 00000 n 0003312696 00000 n 0003313123 00000 n 0003313537 00000 n 0003313944 00000 n 0003154735 00000 n 0003155145 00000 n 0003155644 00000 n 0003156063 00000 n 0003156445 00000 n 0002765163 00000 n 0002765581 00000 n 0002766047 00000 n 0002766461 00000 n 0002766888 00000 n 0003113799 00000 n 0002949755 00000 n 0002962167 00000 n 0003004945 00000 n 0003035682 00000 n 0003060422 00000 n 0003086824 00000 n 0002874393 00000 n 0002889373 00000 n 0002790896 00000 n 0002798802 00000 n 0002835098 00000 n 0002767270 00000 n 0002872012 00000 n 0002869676 00000 n 0002947374 00000 n 0003111645 00000 n 0003109264 00000 n 0003106883 00000 n 0003104502 00000 n 0003102121 00000 n 0003270721 00000 n 0003271155 00000 n 0003224353 00000 n 0003224382 00000 n 0003262163 00000 n 0003206023 00000 n 0003182963 00000 n 0003156876 00000 n 0003270423 00000 n 0003262204 00000 n 0003270563 00000 n 0003301816 00000 n 0003301957 00000 n 0003302098 00000 n 0003302238 00000 n 0003302379 00000 n 0003302519 00000 n 0003302660 00000 n 0003302801 00000 n 0003302942 00000 n 0003303081 00000 n 0003303222 00000 n 0003303363 00000 n 0003303504 00000 n 0003303645 00000 n 0003303785 00000 n 0003303926 00000 n 0003304066 00000 n 0003304207 00000 n 0003304347 00000 n 0003304488 00000 n 0003304629 00000 n 0003304770 00000 n 0003304911 00000 n 0003305052 00000 n 0003305193 00000 n 0003305334 00000 n 0003305475 00000 n 0003305616 00000 n 0003305757 00000 n 0003305898 00000 n 0003306039 00000 n 0003306180 00000 n 0003306321 00000 n 0003306462 00000 n 0003306603 00000 n 0003306744 00000 n 0003306885 00000 n 0003307026 00000 n 0003307167 00000 n 0003307308 00000 n 0003307449 00000 n 0003307590 00000 n 0003307731 00000 n 0003307872 00000 n 0003308013 00000 n 0003308154 00000 n 0003312201 00000 n 0003312112 00000 n 0003312018 00000 n 0003311936 00000 n 0003311854 00000 n 0003311768 00000 n 0003311690 00000 n 0003311607 00000 n 0003311519 00000 n 0003311438 00000 n 0003311357 00000 n 0003311269 00000 n 0003311172 00000 n 0003311075 00000 n 0003310986 00000 n 0003310897 00000 n 0003310815 00000 n 0003310731 00000 n 0003310640 00000 n 0003310549 00000 n 0003310469 00000 n 0003310382 00000 n 0003310293 00000 n 0003310204 00000 n 0003310112 00000 n 0003310020 00000 n 0003309941 00000 n 0003309853 00000 n 0003309765 00000 n 0003309673 00000 n 0003309589 00000 n 0003309505 00000 n 0003309418 00000 n 0003309331 00000 n 0003309244 00000 n 0003309156 00000 n 0003309069 00000 n 0003308978 00000 n 0003308889 00000 n 0003308800 00000 n 0003308706 00000 n 0003308624 00000 n 0003308542 00000 n 0003308456 00000 n 0003308378 00000 n 0003308295 00000 n 0003507897 00000 n 0003452325 00000 n 0003463533 00000 n 0003374140 00000 n 0003391687 00000 n 0003347006 00000 n 0003314367 00000 n 0003314648 00000 n 0003340391 00000 n 0003340532 00000 n 0003340672 00000 n 0003340813 00000 n 0003340954 00000 n 0003341094 00000 n 0003341235 00000 n 0003341376 00000 n 0003341517 00000 n 0003341657 00000 n 0003341798 00000 n 0003341939 00000 n 0003342080 00000 n 0003342221 00000 n 0003342362 00000 n 0003342503 00000 n 0003342644 00000 n 0003342785 00000 n 0003342926 00000 n 0003343066 00000 n 0003343207 00000 n 0003343348 00000 n 0003343489 00000 n 0003343629 00000 n 0003343770 00000 n 0003343911 00000 n 0003344052 00000 n 0003344193 00000 n 0003344333 00000 n 0003346918 00000 n 0003346837 00000 n 0003346756 00000 n 0003346668 00000 n 0003346571 00000 n 0003346482 00000 n 0003346393 00000 n 0003346311 00000 n 0003346227 00000 n 0003346136 00000 n 0003346045 00000 n 0003345965 00000 n 0003345878 00000 n 0003345789 00000 n 0003345700 00000 n 0003345608 00000 n 0003345516 00000 n 0003345437 00000 n 0003345349 00000 n 0003345261 00000 n 0003345169 00000 n 0003345085 00000 n 0003345001 00000 n 0003344914 00000 n 0003344827 00000 n 0003344740 00000 n 0003344652 00000 n 0003344565 00000 n 0003344474 00000 n 0003449989 00000 n 0003505094 00000 n 0003691524 00000 n 0003691670 00000 n 0003664902 00000 n 0003665111 00000 n 0003622098 00000 n 0003622127 00000 n 0003656345 00000 n 0003601751 00000 n 0003570430 00000 n 0003664605 00000 n 0003656386 00000 n 0003664744 00000 n 0003686687 00000 n 0003686828 00000 n 0003686968 00000 n 0003687109 00000 n 0003687250 00000 n 0003687390 00000 n 0003687531 00000 n 0003687672 00000 n 0003687813 00000 n 0003687954 00000 n 0003688094 00000 n 0003688235 00000 n 0003688375 00000 n 0003688516 00000 n 0003688657 00000 n 0003688798 00000 n 0003688939 00000 n 0003689080 00000 n 0003689220 00000 n 0003689361 00000 n 0003689501 00000 n 0003691436 00000 n 0003691344 00000 n 0003691252 00000 n 0003691170 00000 n 0003691079 00000 n 0003690988 00000 n 0003690901 00000 n 0003690810 00000 n 0003690728 00000 n 0003690640 00000 n 0003690551 00000 n 0003690462 00000 n 0003690373 00000 n 0003690284 00000 n 0003690203 00000 n 0003690105 00000 n 0003690006 00000 n 0003689907 00000 n 0003689818 00000 n 0003689729 00000 n 0003689641 00000 n 0003712335 00000 n 0003712476 00000 n 0003712617 00000 n 0003712757 00000 n 0003712898 00000 n 0003713039 00000 n 0003713180 00000 n 0003713321 00000 n 0003713462 00000 n 0003713603 00000 n 0003713744 00000 n 0003713885 00000 n 0003714026 00000 n 0003714167 00000 n 0003715501 00000 n 0003715412 00000 n 0003715321 00000 n 0003715227 00000 n 0003715133 00000 n 0003715041 00000 n 0003714947 00000 n 0003714855 00000 n 0003714766 00000 n 0003714684 00000 n 0003714590 00000 n 0003714496 00000 n 0003714402 00000 n 0003714308 00000 n 0003817409 00000 n 0003792485 00000 n 0003767946 00000 n 0003743566 00000 n 0003717523 00000 n 0004682848 00000 n 0004683288 00000 n 0004683727 00000 n 0004684142 00000 n 0004684556 00000 n 0004525622 00000 n 0004526032 00000 n 0004526531 00000 n 0004526924 00000 n 0004527306 00000 n 0004386499 00000 n 0004386881 00000 n 0004387262 00000 n 0004387669 00000 n 0004388092 00000 n 0004005154 00000 n 0004005653 00000 n 0004006059 00000 n 0004006486 00000 n 0004006926 00000 n 0003843008 00000 n 0003843439 00000 n 0003843833 00000 n 0003844256 00000 n 0003844666 00000 n 0003979375 00000 n 0003954340 00000 n 0003925959 00000 n 0003926096 00000 n 0003886387 00000 n 0003886713 00000 n 0003845165 00000 n 0003845194 00000 n 0003877830 00000 n 0003886090 00000 n 0003877871 00000 n 0003886229 00000 n 0003918094 00000 n 0003918235 00000 n 0003918376 00000 n 0003918516 00000 n 0003918657 00000 n 0003918798 00000 n 0003918939 00000 n 0003919080 00000 n 0003919221 00000 n 0003919361 00000 n 0003919502 00000 n 0003919642 00000 n 0003919782 00000 n 0003919922 00000 n 0003920062 00000 n 0003920203 00000 n 0003920344 00000 n 0003920485 00000 n 0003920625 00000 n 0003920765 00000 n 0003920906 00000 n 0003921047 00000 n 0003921187 00000 n 0003921328 00000 n 0003921469 00000 n 0003921609 00000 n 0003921749 00000 n 0003921890 00000 n 0003922031 00000 n 0003922171 00000 n 0003922312 00000 n 0003922453 00000 n 0003922594 00000 n 0003922735 00000 n 0003925870 00000 n 0003925781 00000 n 0003925699 00000 n 0003925602 00000 n 0003925505 00000 n 0003925410 00000 n 0003925315 00000 n 0003925219 00000 n 0003925127 00000 n 0003925031 00000 n 0003924935 00000 n 0003924847 00000 n 0003924758 00000 n 0003924669 00000 n 0003924580 00000 n 0003924491 00000 n 0003924402 00000 n 0003924321 00000 n 0003924233 00000 n 0003924145 00000 n 0003924063 00000 n 0003923975 00000 n 0003923887 00000 n 0003923800 00000 n 0003923711 00000 n 0003923622 00000 n 0003923540 00000 n 0003923443 00000 n 0003923348 00000 n 0003923252 00000 n 0003923160 00000 n 0003923068 00000 n 0003922972 00000 n 0003922876 00000 n 0003951372 00000 n 0003951513 00000 n 0003951654 00000 n 0003951795 00000 n 0003951936 00000 n 0003952077 00000 n 0003952218 00000 n 0003952359 00000 n 0003952500 00000 n 0003952641 00000 n 0003952782 00000 n 0003952923 00000 n 0003953064 00000 n 0003954252 00000 n 0003954163 00000 n 0003954074 00000 n 0003953985 00000 n 0003953896 00000 n 0003953807 00000 n 0003953726 00000 n 0003953638 00000 n 0003953550 00000 n 0003953468 00000 n 0003953380 00000 n 0003953292 00000 n 0003953205 00000 n 0004343005 00000 n 0004343034 00000 n 0004377943 00000 n 0004322656 00000 n 0004221899 00000 n 0004238402 00000 n 0004148539 00000 n 0004163826 00000 n 0004179199 00000 n 0004197753 00000 n 0004007392 00000 n 0004021075 00000 n 0004078044 00000 n 0004101953 00000 n 0004123188 00000 n 0004146592 00000 n 0004144645 00000 n 0004142707 00000 n 0004140760 00000 n 0004219952 00000 n 0004218005 00000 n 0004216058 00000 n 0004320709 00000 n 0004386203 00000 n 0004377984 00000 n 0004386343 00000 n 0004500920 00000 n 0004474323 00000 n 0004447549 00000 n 0004424714 00000 n 0004424788 00000 n 0004388489 00000 n 0004388824 00000 n 0004416701 00000 n 0004416842 00000 n 0004416983 00000 n 0004417122 00000 n 0004417263 00000 n 0004417403 00000 n 0004417544 00000 n 0004417685 00000 n 0004417826 00000 n 0004417967 00000 n 0004418108 00000 n 0004418249 00000 n 0004418389 00000 n 0004418530 00000 n 0004418671 00000 n 0004418810 00000 n 0004418949 00000 n 0004419090 00000 n 0004419231 00000 n 0004419372 00000 n 0004419513 00000 n 0004419654 00000 n 0004419795 00000 n 0004419936 00000 n 0004420077 00000 n 0004420218 00000 n 0004420359 00000 n 0004420500 00000 n 0004420641 00000 n 0004420782 00000 n 0004420923 00000 n 0004421064 00000 n 0004421205 00000 n 0004421346 00000 n 0004421487 00000 n 0004424625 00000 n 0004424536 00000 n 0004424442 00000 n 0004424359 00000 n 0004424276 00000 n 0004424194 00000 n 0004424108 00000 n 0004424022 00000 n 0004423931 00000 n 0004423842 00000 n 0004423753 00000 n 0004423659 00000 n 0004423565 00000 n 0004423476 00000 n 0004423391 00000 n 0004423300 00000 n 0004423209 00000 n 0004423123 00000 n 0004423039 00000 n 0004422955 00000 n 0004422866 00000 n 0004422782 00000 n 0004422698 00000 n 0004422609 00000 n 0004422520 00000 n 0004422431 00000 n 0004422342 00000 n 0004422251 00000 n 0004422160 00000 n 0004422074 00000 n 0004421983 00000 n 0004421902 00000 n 0004421805 00000 n 0004421708 00000 n 0004421628 00000 n 0004446149 00000 n 0004446290 00000 n 0004446431 00000 n 0004446572 00000 n 0004446713 00000 n 0004446854 00000 n 0004447458 00000 n 0004447364 00000 n 0004447270 00000 n 0004447179 00000 n 0004447089 00000 n 0004446995 00000 n 0004650357 00000 n 0004650737 00000 n 0004600960 00000 n 0004600989 00000 n 0004641802 00000 n 0004584611 00000 n 0004560587 00000 n 0004527725 00000 n 0004650062 00000 n 0004641843 00000 n 0004650201 00000 n 0004673632 00000 n 0004673772 00000 n 0004673912 00000 n 0004674052 00000 n 0004674193 00000 n 0004674334 00000 n 0004674475 00000 n 0004674616 00000 n 0004674757 00000 n 0004674897 00000 n 0004675038 00000 n 0004675179 00000 n 0004675320 00000 n 0004675461 00000 n 0004675602 00000 n 0004675743 00000 n 0004675884 00000 n 0004676025 00000 n 0004676165 00000 n 0004676306 00000 n 0004676447 00000 n 0004676587 00000 n 0004676727 00000 n 0004676867 00000 n 0004677008 00000 n 0004677149 00000 n 0004677290 00000 n 0004677431 00000 n 0004677572 00000 n 0004677712 00000 n 0004677853 00000 n 0004677994 00000 n 0004678135 00000 n 0004678276 00000 n 0004678417 00000 n 0004678558 00000 n 0004678699 00000 n 0004678840 00000 n 0004678980 00000 n 0004679121 00000 n 0004682757 00000 n 0004682671 00000 n 0004682577 00000 n 0004682483 00000 n 0004682390 00000 n 0004682297 00000 n 0004682209 00000 n 0004682121 00000 n 0004682036 00000 n 0004681951 00000 n 0004681859 00000 n 0004681767 00000 n 0004681676 00000 n 0004681585 00000 n 0004681505 00000 n 0004681411 00000 n 0004681314 00000 n 0004681217 00000 n 0004681136 00000 n 0004681055 00000 n 0004680964 00000 n 0004680878 00000 n 0004680784 00000 n 0004680690 00000 n 0004680597 00000 n 0004680504 00000 n 0004680416 00000 n 0004680328 00000 n 0004680243 00000 n 0004680158 00000 n 0004680066 00000 n 0004679974 00000 n 0004679883 00000 n 0004679792 00000 n 0004679712 00000 n 0004679618 00000 n 0004679521 00000 n 0004679424 00000 n 0004679343 00000 n 0004679262 00000 n 0005124845 00000 n 0005138714 00000 n 0005200874 00000 n 0005258247 00000 n 0005001329 00000 n 0005023248 00000 n 0004833666 00000 n 0004834718 00000 n 0004878681 00000 n 0004708974 00000 n 0004722372 00000 n 0004684963 00000 n 0004831719 00000 n 0004999382 00000 n 0004997435 00000 n 0005122739 00000 n 0005319666 00000 n 0005317719 00000 n 0005315772 00000 n 0006270560 00000 n 0006270970 00000 n 0006271469 00000 n 0006271875 00000 n 0006272306 00000 n 0006132847 00000 n 0006133254 00000 n 0006133677 00000 n 0006134087 00000 n 0006134586 00000 n 0005876476 00000 n 0005876858 00000 n 0005877227 00000 n 0005877713 00000 n 0005878095 00000 n 0005743837 00000 n 0005744255 00000 n 0005744686 00000 n 0005745093 00000 n 0005745516 00000 n 0005322133 00000 n 0005322632 00000 n 0005323038 00000 n 0005323465 00000 n 0005323892 00000 n 0005699023 00000 n 0005699052 00000 n 0005735281 00000 n 0005679007 00000 n 0005600827 00000 n 0005618194 00000 n 0005661028 00000 n 0005483329 00000 n 0005502689 00000 n 0005540770 00000 n 0005324332 00000 n 0005338407 00000 n 0005386947 00000 n 0005481382 00000 n 0005479435 00000 n 0005598880 00000 n 0005596933 00000 n 0005677060 00000 n 0005675348 00000 n 0005743541 00000 n 0005735322 00000 n 0005743681 00000 n 0005841732 00000 n 0005814332 00000 n 0005789356 00000 n 0005761327 00000 n 0005761455 00000 n 0005745913 00000 n 0005746023 00000 n 0005758984 00000 n 0005759125 00000 n 0005759266 00000 n 0005759407 00000 n 0005759548 00000 n 0005759689 00000 n 0005759830 00000 n 0005759971 00000 n 0005760112 00000 n 0005760253 00000 n 0005761236 00000 n 0005761148 00000 n 0005761051 00000 n 0005760960 00000 n 0005760862 00000 n 0005760764 00000 n 0005760676 00000 n 0005760588 00000 n 0005760491 00000 n 0005760394 00000 n 0005786544 00000 n 0005786684 00000 n 0005786824 00000 n 0005786965 00000 n 0005787106 00000 n 0005787247 00000 n 0005787387 00000 n 0005787528 00000 n 0005787669 00000 n 0005787810 00000 n 0005787951 00000 n 0005788092 00000 n 0005789260 00000 n 0005789169 00000 n 0005789081 00000 n 0005788984 00000 n 0005788887 00000 n 0005788796 00000 n 0005788698 00000 n 0005788610 00000 n 0005788522 00000 n 0005788425 00000 n 0005788329 00000 n 0005788233 00000 n 0006108563 00000 n 0006083956 00000 n 0005931238 00000 n 0005943799 00000 n 0005975144 00000 n 0005989668 00000 n 0006012165 00000 n 0006029686 00000 n 0006048052 00000 n 0005906435 00000 n 0005878513 00000 n 0006080689 00000 n 0006077435 00000 n 0006075099 00000 n 0006073165 00000 n 0006071231 00000 n 0006067964 00000 n 0006246747 00000 n 0006219114 00000 n 0006219215 00000 n 0006202391 00000 n 0006202528 00000 n 0006154713 00000 n 0006154742 00000 n 0006193835 00000 n 0006134992 00000 n 0006202095 00000 n 0006193876 00000 n 0006202235 00000 n 0006216100 00000 n 0006216241 00000 n 0006216382 00000 n 0006216523 00000 n 0006216664 00000 n 0006216805 00000 n 0006216946 00000 n 0006217087 00000 n 0006217228 00000 n 0006217369 00000 n 0006217510 00000 n 0006217651 00000 n 0006217792 00000 n 0006219020 00000 n 0006218929 00000 n 0006218840 00000 n 0006218751 00000 n 0006218662 00000 n 0006218573 00000 n 0006218484 00000 n 0006218395 00000 n 0006218299 00000 n 0006218203 00000 n 0006218116 00000 n 0006218026 00000 n 0006217932 00000 n 0006244670 00000 n 0006244811 00000 n 0006244951 00000 n 0006245092 00000 n 0006245233 00000 n 0006245374 00000 n 0006245515 00000 n 0006245656 00000 n 0006245797 00000 n 0006246656 00000 n 0006246567 00000 n 0006246478 00000 n 0006246389 00000 n 0006246300 00000 n 0006246211 00000 n 0006246115 00000 n 0006246028 00000 n 0006245938 00000 n 0006747239 00000 n 0006747439 00000 n 0006705536 00000 n 0006705565 00000 n 0006738684 00000 n 0006683003 00000 n 0006658660 00000 n 0006272875 00000 n 0006465368 00000 n 0006465503 00000 n 0006465638 00000 n 0006465773 00000 n 0006465908 00000 n 0006466144 00000 n 0006466380 00000 n 0006466620 00000 n 0006437574 00000 n 0006437615 00000 n 0006437656 00000 n 0006437697 00000 n 0006458666 00000 n 0006451964 00000 n 0006445012 00000 n 0006437738 00000 n 0006633982 00000 n 0006634011 00000 n 0006609306 00000 n 0006609335 00000 n 0006583834 00000 n 0006583863 00000 n 0006558127 00000 n 0006558156 00000 n 0006535449 00000 n 0006512772 00000 n 0006489816 00000 n 0006466860 00000 n 0006467120 00000 n 0006490076 00000 n 0006513032 00000 n 0006535709 00000 n 0006558595 00000 n 0006558929 00000 n 0006559000 00000 n 0006559275 00000 n 0006559370 00000 n 0006584298 00000 n 0006584624 00000 n 0006584695 00000 n 0006584970 00000 n 0006585065 00000 n 0006609758 00000 n 0006610076 00000 n 0006610147 00000 n 0006610422 00000 n 0006610517 00000 n 0006634434 00000 n 0006634752 00000 n 0006634823 00000 n 0006635098 00000 n 0006635193 00000 n 0006746944 00000 n 0006738725 00000 n 0006747083 00000 n 0006766989 00000 n 0006767130 00000 n 0006767270 00000 n 0006767411 00000 n 0006767551 00000 n 0006767691 00000 n 0006767832 00000 n 0006767973 00000 n 0006768113 00000 n 0006768253 00000 n 0006768394 00000 n 0006768535 00000 n 0006768676 00000 n 0006768817 00000 n 0006768958 00000 n 0006769099 00000 n 0006769240 00000 n 0006769381 00000 n 0006769521 00000 n 0006769662 00000 n 0006771486 00000 n 0006771405 00000 n 0006771324 00000 n 0006771236 00000 n 0006771147 00000 n 0006771050 00000 n 0006770953 00000 n 0006770865 00000 n 0006770768 00000 n 0006770675 00000 n 0006770582 00000 n 0006770496 00000 n 0006770407 00000 n 0006770319 00000 n 0006770232 00000 n 0006770144 00000 n 0006770056 00000 n 0006769968 00000 n 0006769884 00000 n 0006769803 00000 n 0007618346 00000 n 0007618764 00000 n 0007619182 00000 n 0007619613 00000 n 0007620036 00000 n 0007470051 00000 n 0007470448 00000 n 0007470947 00000 n 0007471353 00000 n 0007471772 00000 n 0007280551 00000 n 0007280969 00000 n 0007281420 00000 n 0007281834 00000 n 0007282241 00000 n 0007111677 00000 n 0007112074 00000 n 0007112573 00000 n 0007112979 00000 n 0007113406 00000 n 0006772103 00000 n 0006772562 00000 n 0006773013 00000 n 0006773477 00000 n 0006773884 00000 n 0007038581 00000 n 0007057273 00000 n 0007066555 00000 n 0006935919 00000 n 0006956384 00000 n 0006993083 00000 n 0006831761 00000 n 0006848966 00000 n 0006888330 00000 n 0006805126 00000 n 0006774307 00000 n 0006774498 00000 n 0006800765 00000 n 0006800906 00000 n 0006801047 00000 n 0006801188 00000 n 0006801329 00000 n 0006801470 00000 n 0006801611 00000 n 0006801752 00000 n 0006801893 00000 n 0006802034 00000 n 0006802175 00000 n 0006802316 00000 n 0006802457 00000 n 0006802598 00000 n 0006802739 00000 n 0006802880 00000 n 0006803021 00000 n 0006803162 00000 n 0006803303 00000 n 0006805030 00000 n 0006804949 00000 n 0006804868 00000 n 0006804780 00000 n 0006804691 00000 n 0006804594 00000 n 0006804506 00000 n 0006804409 00000 n 0006804316 00000 n 0006804223 00000 n 0006804137 00000 n 0006804048 00000 n 0006803960 00000 n 0006803873 00000 n 0006803785 00000 n 0006803697 00000 n 0006803609 00000 n 0006803525 00000 n 0006803444 00000 n 0006933583 00000 n 0006931247 00000 n 0007036245 00000 n 0007033909 00000 n 0007109743 00000 n 0007107407 00000 n 0007266831 00000 n 0007266977 00000 n 0007222339 00000 n 0007222368 00000 n 0007258276 00000 n 0007200501 00000 n 0007141899 00000 n 0007161087 00000 n 0007113824 00000 n 0007198178 00000 n 0007266536 00000 n 0007258317 00000 n 0007266675 00000 n 0007277343 00000 n 0007277482 00000 n 0007277622 00000 n 0007277762 00000 n 0007277903 00000 n 0007278043 00000 n 0007278183 00000 n 0007278324 00000 n 0007278465 00000 n 0007278606 00000 n 0007278747 00000 n 0007278888 00000 n 0007279029 00000 n 0007279170 00000 n 0007280472 00000 n 0007280383 00000 n 0007280292 00000 n 0007280201 00000 n 0007280120 00000 n 0007280032 00000 n 0007279945 00000 n 0007279851 00000 n 0007279772 00000 n 0007279675 00000 n 0007279578 00000 n 0007279484 00000 n 0007279390 00000 n 0007279311 00000 n 0007431204 00000 n 0007384999 00000 n 0007407946 00000 n 0007341976 00000 n 0007357396 00000 n 0007315957 00000 n 0007282664 00000 n 0007282954 00000 n 0007309105 00000 n 0007309246 00000 n 0007309387 00000 n 0007309528 00000 n 0007309669 00000 n 0007309810 00000 n 0007309951 00000 n 0007310091 00000 n 0007310232 00000 n 0007310373 00000 n 0007310513 00000 n 0007310654 00000 n 0007310795 00000 n 0007310936 00000 n 0007311077 00000 n 0007311218 00000 n 0007311359 00000 n 0007311500 00000 n 0007311641 00000 n 0007311782 00000 n 0007311923 00000 n 0007312064 00000 n 0007312205 00000 n 0007312346 00000 n 0007312487 00000 n 0007312628 00000 n 0007312769 00000 n 0007312910 00000 n 0007313051 00000 n 0007313192 00000 n 0007315866 00000 n 0007315781 00000 n 0007315700 00000 n 0007315619 00000 n 0007315538 00000 n 0007315444 00000 n 0007315356 00000 n 0007315265 00000 n 0007315186 00000 n 0007315097 00000 n 0007315006 00000 n 0007314915 00000 n 0007314834 00000 n 0007314746 00000 n 0007314659 00000 n 0007314565 00000 n 0007314486 00000 n 0007314389 00000 n 0007314292 00000 n 0007314198 00000 n 0007314104 00000 n 0007314025 00000 n 0007313934 00000 n 0007313849 00000 n 0007313768 00000 n 0007313687 00000 n 0007313606 00000 n 0007313512 00000 n 0007313424 00000 n 0007313333 00000 n 0007382602 00000 n 0007429257 00000 n 0007591798 00000 n 0007592070 00000 n 0007544813 00000 n 0007544842 00000 n 0007583243 00000 n 0007524526 00000 n 0007498202 00000 n 0007472203 00000 n 0007591503 00000 n 0007583284 00000 n 0007591642 00000 n 0007611988 00000 n 0007612129 00000 n 0007612270 00000 n 0007612411 00000 n 0007612552 00000 n 0007612693 00000 n 0007612833 00000 n 0007612974 00000 n 0007613114 00000 n 0007613255 00000 n 0007613396 00000 n 0007613537 00000 n 0007613677 00000 n 0007613817 00000 n 0007613958 00000 n 0007614099 00000 n 0007614240 00000 n 0007614381 00000 n 0007614522 00000 n 0007614663 00000 n 0007614804 00000 n 0007614945 00000 n 0007615086 00000 n 0007615227 00000 n 0007615368 00000 n 0007615509 00000 n 0007615650 00000 n 0007615791 00000 n 0007618249 00000 n 0007618161 00000 n 0007618079 00000 n 0007617991 00000 n 0007617909 00000 n 0007617827 00000 n 0007617745 00000 n 0007617653 00000 n 0007617561 00000 n 0007617473 00000 n 0007617385 00000 n 0007617301 00000 n 0007617217 00000 n 0007617129 00000 n 0007617041 00000 n 0007616958 00000 n 0007616875 00000 n 0007616792 00000 n 0007616703 00000 n 0007616621 00000 n 0007616539 00000 n 0007616457 00000 n 0007616369 00000 n 0007616281 00000 n 0007616193 00000 n 0007616105 00000 n 0007616017 00000 n 0007615932 00000 n 0007741615 00000 n 0007708591 00000 n 0007682260 00000 n 0007658192 00000 n 0007658230 00000 n 0007620446 00000 n 0007620826 00000 n 0007649007 00000 n 0007649148 00000 n 0007649289 00000 n 0007649430 00000 n 0007649571 00000 n 0007649712 00000 n 0007649853 00000 n 0007649994 00000 n 0007650135 00000 n 0007650275 00000 n 0007650416 00000 n 0007650557 00000 n 0007650698 00000 n 0007650839 00000 n 0007650980 00000 n 0007651121 00000 n 0007651262 00000 n 0007651403 00000 n 0007651544 00000 n 0007651685 00000 n 0007651826 00000 n 0007651967 00000 n 0007652108 00000 n 0007652249 00000 n 0007652390 00000 n 0007652531 00000 n 0007652672 00000 n 0007652813 00000 n 0007652954 00000 n 0007653095 00000 n 0007653236 00000 n 0007653377 00000 n 0007653518 00000 n 0007653659 00000 n 0007653800 00000 n 0007653941 00000 n 0007654082 00000 n 0007654223 00000 n 0007654364 00000 n 0007654505 00000 n 0007658095 00000 n 0007658006 00000 n 0007657917 00000 n 0007657820 00000 n 0007657723 00000 n 0007657635 00000 n 0007657553 00000 n 0007657465 00000 n 0007657383 00000 n 0007657301 00000 n 0007657219 00000 n 0007657127 00000 n 0007657035 00000 n 0007656947 00000 n 0007656859 00000 n 0007656775 00000 n 0007656691 00000 n 0007656603 00000 n 0007656515 00000 n 0007656432 00000 n 0007656349 00000 n 0007656266 00000 n 0007656177 00000 n 0007656095 00000 n 0007656013 00000 n 0007655931 00000 n 0007655843 00000 n 0007655755 00000 n 0007655667 00000 n 0007655579 00000 n 0007655491 00000 n 0007655406 00000 n 0007655309 00000 n 0007655212 00000 n 0007655115 00000 n 0007655018 00000 n 0007654929 00000 n 0007654840 00000 n 0007654743 00000 n 0007654646 00000 n 0007681785 00000 n 0007681926 00000 n 0007682163 00000 n 0007682066 00000 n 0008391925 00000 n 0008392313 00000 n 0008392701 00000 n 0008393036 00000 n 0008393371 00000 n 0008285481 00000 n 0008285880 00000 n 0008286279 00000 n 0008286678 00000 n 0008287077 00000 n 0008099933 00000 n 0008100339 00000 n 0008100733 00000 n 0008101160 00000 n 0008101578 00000 n 0007930050 00000 n 0007930488 00000 n 0007930906 00000 n 0007931300 00000 n 0007931723 00000 n 0007771822 00000 n 0007772334 00000 n 0007772740 00000 n 0007773171 00000 n 0007773589 00000 n 0007883511 00000 n 0007883540 00000 n 0007921494 00000 n 0007862085 00000 n 0007835192 00000 n 0007807214 00000 n 0007774016 00000 n 0007797209 00000 n 0007805515 00000 n 0007929754 00000 n 0007921535 00000 n 0007929894 00000 n 0008046957 00000 n 0008063643 00000 n 0008017613 00000 n 0007991938 00000 n 0007961833 00000 n 0007961988 00000 n 0007932133 00000 n 0007932396 00000 n 0007955625 00000 n 0007955766 00000 n 0007955907 00000 n 0007956048 00000 n 0007956189 00000 n 0007956330 00000 n 0007956471 00000 n 0007956612 00000 n 0007956752 00000 n 0007956892 00000 n 0007957033 00000 n 0007957174 00000 n 0007957314 00000 n 0007957455 00000 n 0007957596 00000 n 0007957736 00000 n 0007957877 00000 n 0007958018 00000 n 0007958159 00000 n 0007958300 00000 n 0007958441 00000 n 0007958582 00000 n 0007958723 00000 n 0007958864 00000 n 0007959005 00000 n 0007959146 00000 n 0007959287 00000 n 0007961744 00000 n 0007961647 00000 n 0007961560 00000 n 0007961473 00000 n 0007961376 00000 n 0007961294 00000 n 0007961211 00000 n 0007961122 00000 n 0007961022 00000 n 0007960925 00000 n 0007960828 00000 n 0007960749 00000 n 0007960661 00000 n 0007960577 00000 n 0007960493 00000 n 0007960400 00000 n 0007960311 00000 n 0007960226 00000 n 0007960145 00000 n 0007960064 00000 n 0007959967 00000 n 0007959878 00000 n 0007959781 00000 n 0007959694 00000 n 0007959607 00000 n 0007959510 00000 n 0007959428 00000 n 0007988499 00000 n 0007988640 00000 n 0007988781 00000 n 0007988922 00000 n 0007989063 00000 n 0007989204 00000 n 0007989344 00000 n 0007989485 00000 n 0007989626 00000 n 0007989767 00000 n 0007989908 00000 n 0007990049 00000 n 0007990189 00000 n 0007990330 00000 n 0007990470 00000 n 0007991855 00000 n 0007991766 00000 n 0007991666 00000 n 0007991569 00000 n 0007991472 00000 n 0007991393 00000 n 0007991305 00000 n 0007991221 00000 n 0007991137 00000 n 0007991044 00000 n 0007990955 00000 n 0007990870 00000 n 0007990789 00000 n 0007990708 00000 n 0007990611 00000 n 0008098234 00000 n 0008265775 00000 n 0008242625 00000 n 0008182323 00000 n 0008196900 00000 n 0008158802 00000 n 0008102016 00000 n 0008119614 00000 n 0008157103 00000 n 0008240691 00000 n 0008374116 00000 n 0008374307 00000 n 0008357954 00000 n 0008358127 00000 n 0008343699 00000 n 0008343854 00000 n 0008332293 00000 n 0008332430 00000 n 0008287589 00000 n 0008287618 00000 n 0008323738 00000 n 0008331998 00000 n 0008323779 00000 n 0008332137 00000 n 0008340839 00000 n 0008340980 00000 n 0008341121 00000 n 0008341262 00000 n 0008341403 00000 n 0008341544 00000 n 0008341685 00000 n 0008341826 00000 n 0008341967 00000 n 0008342108 00000 n 0008342249 00000 n 0008342390 00000 n 0008342531 00000 n 0008343620 00000 n 0008343541 00000 n 0008343462 00000 n 0008343383 00000 n 0008343304 00000 n 0008343225 00000 n 0008343146 00000 n 0008343067 00000 n 0008342988 00000 n 0008342909 00000 n 0008342830 00000 n 0008342751 00000 n 0008342672 00000 n 0008354670 00000 n 0008354811 00000 n 0008354952 00000 n 0008355092 00000 n 0008355233 00000 n 0008355374 00000 n 0008355515 00000 n 0008355656 00000 n 0008355797 00000 n 0008355938 00000 n 0008356079 00000 n 0008356220 00000 n 0008356361 00000 n 0008356502 00000 n 0008356643 00000 n 0008357876 00000 n 0008357798 00000 n 0008357720 00000 n 0008357642 00000 n 0008357564 00000 n 0008357486 00000 n 0008357408 00000 n 0008357330 00000 n 0008357252 00000 n 0008357174 00000 n 0008357096 00000 n 0008357018 00000 n 0008356940 00000 n 0008356862 00000 n 0008356783 00000 n 0008370378 00000 n 0008370519 00000 n 0008370660 00000 n 0008370801 00000 n 0008370942 00000 n 0008371083 00000 n 0008371224 00000 n 0008371365 00000 n 0008371505 00000 n 0008371646 00000 n 0008371787 00000 n 0008371928 00000 n 0008372069 00000 n 0008372210 00000 n 0008372350 00000 n 0008372491 00000 n 0008372632 00000 n 0008374037 00000 n 0008373958 00000 n 0008373879 00000 n 0008373800 00000 n 0008373721 00000 n 0008373642 00000 n 0008373563 00000 n 0008373484 00000 n 0008373405 00000 n 0008373326 00000 n 0008373247 00000 n 0008373168 00000 n 0008373089 00000 n 0008373010 00000 n 0008372931 00000 n 0008372852 00000 n 0008372773 00000 n 0008387768 00000 n 0008387909 00000 n 0008388050 00000 n 0008388190 00000 n 0008388331 00000 n 0008388472 00000 n 0008388613 00000 n 0008388754 00000 n 0008388895 00000 n 0008389035 00000 n 0008389176 00000 n 0008389317 00000 n 0008389458 00000 n 0008389599 00000 n 0008389740 00000 n 0008389881 00000 n 0008390020 00000 n 0008390161 00000 n 0008390302 00000 n 0008391847 00000 n 0008391769 00000 n 0008391691 00000 n 0008391613 00000 n 0008391535 00000 n 0008391457 00000 n 0008391379 00000 n 0008391301 00000 n 0008391223 00000 n 0008391145 00000 n 0008391067 00000 n 0008390989 00000 n 0008390911 00000 n 0008390833 00000 n 0008390755 00000 n 0008390677 00000 n 0008390599 00000 n 0008390521 00000 n 0008390443 00000 n 0008528644 00000 n 0008577223 00000 n 0008577264 00000 n 0008501074 00000 n 0008521653 00000 n 0008521694 00000 n 0008475594 00000 n 0008462694 00000 n 0008393766 00000 n 0008462440 00000 n 0008523003 00000 n 0008521735 00000 n 0008582135 00000 n 0008577305 00000 n 0008586279 00000 n trailer <<396460A757D7B14FA6D23BE93B95539D>]>> startxref 8586505 %%EOF 1 0 obj <>>> endobj 2 0 obj <>stream application/pdf CPL_3(85)2023_block_14-08_v3.indd 2024-02-19T18:43:22+05:00 2024-02-19T18:48:40+05:00 2024-02-19T18:48:40+05:00 Adobe InDesign CS6 (Windows) uuid:e4b301bc-5dcb-44f5-8a54-12e0fc094eb8 xmp.did:A755A9BBDED3ED11A964B3B248771B4C xmp.id:BC4FF6C32CCFEE118CAADCFF4804CA6B proof:pdf xmp.iid:BB4FF6C32CCFEE118CAADCFF4804CA6B xmp.did:26E54DB12BCFEE118A53CE1197856127 xmp.did:A755A9BBDED3ED11A964B3B248771B4C default converted from application/x-indesign to application/pdf Adobe InDesign CS6 (Windows) / 2024-02-19T18:43:22+05:00 Adobe PDF Library 10.0.1 False endstream endobj 3 0 obj <> endobj 7 0 obj <> endobj 13 0 obj <> endobj 14 0 obj <> endobj 18 0 obj <> endobj 50 0 obj <> endobj 51 0 obj <>/Resources<>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 52 0 obj <>/Resources<>/ExtGState<>/Font<>/ProcSet[/PDF/Text]/Properties<>/Shading<>/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 53 0 obj <>/Resources<>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 54 0 obj <>/Resources<>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 55 0 obj <>/Resources<>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 56 0 obj <>/Resources<>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 57 0 obj <>/Resources<>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 58 0 obj <>/Resources<>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 59 0 obj <>/Resources<>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 60 0 obj <>/Resources<>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 61 0 obj <>/Resources<>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 62 0 obj <>/Resources<>/ExtGState<>/Font<>/ProcSet[/PDF/Text]/Properties<>/Shading<>/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 63 0 obj <>/Resources<>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 64 0 obj <>/Resources<>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 65 0 obj <>/Resources<>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 66 0 obj <>/Resources<>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 67 0 obj <>/Resources<>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 68 0 obj <>/Resources<>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 69 0 obj <>/Resources<>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 70 0 obj <>/Resources<>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 71 0 obj <>/Resources<>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 72 0 obj <>/Resources<>/ExtGState<>/Font<>/ProcSet[/PDF/Text]/Properties<>/Shading<>/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 73 0 obj <>/Resources<>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 74 0 obj <>/Resources<>/Font<>/ProcSet[/PDF/Text]/Properties<>/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 75 0 obj <>/Resources<>/Font<>/ProcSet[/PDF/Text/ImageC]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 76 0 obj <>/Resources<>/ExtGState<>/Font<>/ProcSet[/PDF/Text/ImageC/ImageI]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 77 0 obj <>/Resources<>/ExtGState<>/Font<>/ProcSet[/PDF/Text/ImageC/ImageI]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 78 0 obj <>/Resources<>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 79 0 obj <>/Resources<>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 80 0 obj <>/Resources<>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 81 0 obj <>/Resources<>/ExtGState<>/Font<>/ProcSet[/PDF/Text]/Properties<>/Shading<>/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 82 0 obj <>/Resources<>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 83 0 obj <>/Resources<>/Font<>/ProcSet[/PDF/Text/ImageC]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 84 0 obj <>/Resources<>/ExtGState<>/Font<>/ProcSet[/PDF/Text/ImageC/ImageI]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 85 0 obj <>/Resources<>/ExtGState<>/Font<>/ProcSet[/PDF/Text/ImageC/ImageI]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 86 0 obj <>/Resources<>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 87 0 obj <>/Resources<>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 88 0 obj <>/Resources<>/Font<>/ProcSet[/PDF/Text]>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 127 0 obj <> endobj 747 0 obj <>/Resources<>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 748 0 obj <>/Resources<>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 749 0 obj <>/Resources<>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 750 0 obj <>/Resources<>/ExtGState<>/Font<>/ProcSet[/PDF/Text]/Properties<>/Shading<>/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 751 0 obj <>/Resources<>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 752 0 obj <>/Resources<>/Font<>/ProcSet[/PDF/Text/ImageC]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 753 0 obj <>/Resources<>/Font<>/ProcSet[/PDF/Text/ImageC]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 754 0 obj <>/Resources<>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 755 0 obj <>/Resources<>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 756 0 obj <>/Resources<>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 757 0 obj <>/Resources<>/ExtGState<>/Font<>/ProcSet[/PDF/Text]/Properties<>/Shading<>/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 758 0 obj <>/Resources<>/Font<>/ProcSet[/PDF/Text/ImageC]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 759 0 obj <>/Resources<>/Font<>/ProcSet[/PDF/Text/ImageB]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 760 0 obj <>/Resources<>/Font<>/ProcSet[/PDF/Text/ImageC]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 761 0 obj <>/Resources<>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 762 0 obj <>/Resources<>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 763 0 obj <>/Resources<>/ExtGState<>/Font<>/ProcSet[/PDF/Text]/Properties<>/Shading<>/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 764 0 obj <>/Resources<>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 765 0 obj <>/Resources<>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 766 0 obj <>/Resources<>/Font<>/ProcSet[/PDF/Text/ImageC]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 767 0 obj <>/Resources<>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 768 0 obj <>/Resources<>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 769 0 obj <>/Resources<>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 770 0 obj <>/Resources<>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 771 0 obj <>/Resources<>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1164 0 obj <>/Resources<>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1165 0 obj <>/Resources<>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1166 0 obj <>/Resources<>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1167 0 obj <>/Resources<>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1168 0 obj <>/Resources<>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1169 0 obj <>/Resources<>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1170 0 obj <>/Resources<>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1171 0 obj <>/Resources<>/ExtGState<>/Font<>/ProcSet[/PDF/Text]/Properties<>/Shading<>/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1172 0 obj <>/Resources<>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1173 0 obj <>/Resources<>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1174 0 obj <>/Resources<>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1175 0 obj <>/Resources<>/Font<>/ProcSet[/PDF/Text/ImageC]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1176 0 obj <>/Resources<>/Font<>/ProcSet[/PDF/Text/ImageC]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1177 0 obj <>/Resources<>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1178 0 obj <>/Resources<>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1179 0 obj <>/Resources<>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1180 0 obj <>/Resources<>/ExtGState<>/Font<>/ProcSet[/PDF/Text]/Properties<>/Shading<>/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1181 0 obj <>/Resources<>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1182 0 obj <>/Resources<>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1183 0 obj <>/Resources<>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1184 0 obj <>/Resources<>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1185 0 obj <>/Resources<>/Font<>/ProcSet[/PDF/Text/ImageC]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1186 0 obj <>/Resources<>/Font<>/ProcSet[/PDF/Text/ImageC]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1187 0 obj <>/Resources<>/Font<>/ProcSet[/PDF/Text/ImageC]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1188 0 obj <>/Resources<>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1468 0 obj <>/Resources<>/Font<>/ProcSet[/PDF/Text/ImageC]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1469 0 obj <>/Resources<>/Font<>/ProcSet[/PDF/Text/ImageC]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1470 0 obj <>/Resources<>/Font<>/ProcSet[/PDF/Text/ImageC]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1471 0 obj <>/Resources<>/Font<>/ProcSet[/PDF/Text/ImageC]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1472 0 obj <>/Resources<>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1473 0 obj <>/Resources<>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1474 0 obj <>/Resources<>/ExtGState<>/Font<>/ProcSet[/PDF/Text]/Properties<>/Shading<>/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1475 0 obj <>/Resources<>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1476 0 obj <>/Resources<>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1477 0 obj <>/Resources<>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1478 0 obj <>/Resources<>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1479 0 obj <>/Resources<>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1480 0 obj <>/Resources<>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1481 0 obj <>/Resources<>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1482 0 obj <>/Resources<>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1483 0 obj <>/Resources<>/ExtGState<>/Font<>/ProcSet[/PDF/Text]/Properties<>/Shading<>/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1484 0 obj <>/Resources<>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1485 0 obj <>/Resources<>/Font<>/ProcSet[/PDF/Text/ImageC]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1486 0 obj <>/Resources<>/Font<>/ProcSet[/PDF/Text/ImageC]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1487 0 obj <>/Resources<>/Font<>/ProcSet[/PDF/Text/ImageC]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1488 0 obj <>/Resources<>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1489 0 obj <>/Resources<>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1490 0 obj <>/Resources<>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1491 0 obj <>/Resources<>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1492 0 obj <>/Resources<>/ExtGState<>/Font<>/ProcSet[/PDF/Text]/Properties<>/Shading<>/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1824 0 obj <>/Resources<>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1825 0 obj <>/Resources<>/ExtGState<>/Font<>/ProcSet[/PDF/Text]/Properties<>/Shading<>/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1826 0 obj <>/Resources<>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1827 0 obj <>/Resources<>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1828 0 obj <>/Resources<>/Font<>/ProcSet[/PDF/Text]/Properties<>/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1829 0 obj <>/Resources<>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1830 0 obj <>/Resources<>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1831 0 obj <>/Resources<>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1832 0 obj <>/Resources<>/ExtGState<>/Font<>/ProcSet[/PDF/Text]/Properties<>/Shading<>/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1833 0 obj <>/Resources<>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1834 0 obj <>/Resources<>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1835 0 obj <>/Resources<>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1836 0 obj <>/Resources<>/Font<>/ProcSet[/PDF/Text/ImageB/ImageC]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1837 0 obj <>/Resources<>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1838 0 obj <>/Resources<>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1839 0 obj <>/Resources<>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1840 0 obj <>/Resources<>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1841 0 obj <>/Resources<>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1842 0 obj <>/Resources<>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1843 0 obj <>/Resources<>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1844 0 obj <>/Resources<>/ExtGState<>/Font<>/ProcSet[/PDF/Text]/Properties<>/Shading<>/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1845 0 obj <>/Resources<>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1846 0 obj <>/Resources<>/Font<>/ProcSet[/PDF/Text/ImageC]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1847 0 obj <>/Resources<>/Font<>/ProcSet[/PDF/Text/ImageC]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1848 0 obj <>/Resources<>/Font<>/ProcSet[/PDF/Text/ImageC]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 2008 0 obj <> endobj 2009 0 obj <> endobj 2010 0 obj <> endobj 2021 0 obj [2050 0 R] endobj 2023 0 obj [2050 0 R] endobj 2025 0 obj [2050 0 R] endobj 2027 0 obj <> endobj 2050 0 obj <> endobj 2052 0 obj <> endobj 2098 0 obj <>/Resources<>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 2099 0 obj <>/Resources<>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 2100 0 obj <>/Resources<>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 2101 0 obj <>/Resources<>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 2102 0 obj <>/Resources<>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 2103 0 obj <>/Resources<>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 2104 0 obj <>/Resources<>/ExtGState<>/Font<>/ProcSet[/PDF/Text]/Properties<>/Shading<>/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 2105 0 obj <>/Resources<>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 2106 0 obj <>/Resources<>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 2107 0 obj <>/Resources<>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 2108 0 obj <>/Resources<>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 2109 0 obj <>/Resources<>/Font<>/ProcSet[/PDF/Text/ImageC]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 2110 0 obj <>/Resources<>/Font<>/ProcSet[/PDF/Text/ImageB]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 2111 0 obj <>/Resources<>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 2112 0 obj <>/Resources<>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 2113 0 obj <>/Resources<>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 2114 0 obj <>/Resources<>/ExtGState<>/Font<>/ProcSet[/PDF/Text]/Properties<>/Shading<>/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 2115 0 obj <>/Resources<>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 2116 0 obj <>/Resources<>/Font<>/ProcSet[/PDF/Text/ImageB]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 2117 0 obj <>/Resources<>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 2118 0 obj <>/Resources<>/Font<>/ProcSet[/PDF/Text/ImageB/ImageC]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 2119 0 obj <>/Resources<>/Font<>/ProcSet[/PDF/Text/ImageC]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 2120 0 obj <>/Resources<>/Font<>/ProcSet[/PDF/Text/ImageC]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 2121 0 obj <>/Resources<>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 2122 0 obj <>/Resources<>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 2448 0 obj <>/Resources<>/Font<>/ProcSet[/PDF/Text]/Properties<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 2449 0 obj <>/Resources<>/Font<>/ProcSet[/PDF/Text]/Properties<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 2450 0 obj <>/Resources<>/Font<>/ProcSet[/PDF/Text]>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 2451 0 obj <>/Resources<>/Font<>/ProcSet[/PDF/Text]>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 2452 0 obj <>/Resources<>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 2453 0 obj <>/Resources<>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 2454 0 obj <>/Resources<>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 2455 0 obj <>/Resources<>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 2456 0 obj <>/Resources<>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 2457 0 obj <>/Resources<>/ExtGState<>/Font<>/ProcSet[/PDF/Text]/Properties<>/Shading<>/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 2458 0 obj <>/Resources<>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 2459 0 obj <>/Resources<>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 2460 0 obj <>/Resources<>/Font<>/ProcSet[/PDF/Text/ImageB]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 2461 0 obj <>/Resources<>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 2462 0 obj <>/Resources<>/Font<>/ProcSet[/PDF/Text/ImageB]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 2463 0 obj <>/Resources<>/Font<>/ProcSet[/PDF/Text/ImageB]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 2464 0 obj <>/Resources<>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 2465 0 obj <>/Resources<>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 2466 0 obj <>/Resources<>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 2467 0 obj <>/Resources<>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 2468 0 obj <>/Resources<>/ExtGState<>/Font<>/ProcSet[/PDF/Text]/Properties<>/Shading<>/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 2469 0 obj <>/Resources<>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 2470 0 obj <>/Resources<>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 2471 0 obj <>/Resources<>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 2472 0 obj <>/Resources<>/Font<>/ProcSet[/PDF/Text/ImageB]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 2743 0 obj <> endobj 2744 0 obj <> endobj 2745 0 obj <> endobj 2746 0 obj <> endobj 2747 0 obj <> endobj 2748 0 obj <> endobj 2749 0 obj <> endobj 2750 0 obj <> endobj 2751 0 obj <> endobj 2752 0 obj <> endobj 2753 0 obj <> endobj 2754 0 obj <> endobj 2755 0 obj <> endobj 2756 0 obj <> endobj 2757 0 obj <> endobj 2758 0 obj <> endobj 2759 0 obj <>/Resources<>>>/Type/Page>> endobj 2760 0 obj <>/Resources<>/Font<>/ProcSet[/PDF/Text]/Properties<>/XObject<>>>/Type/Page>> endobj 2761 0 obj <>stream HWɮ\ Wu.U,:x)E~?}/d+[Kv Sq]rHUnA-k1-?}{?}//X.i GYiAs- +ƆjH)J> 2$ݝXp[+szk?q ;3.nZ)PU;` `r5 rbzEV*\ˏ=[ynZXR"OhY][RaB NQJP\tYezt/jVvEXΑ'4)AkF[M$dqx@EywێU܎\[vcF+{,ɀ$_.,W ݣB eQ AJLZ Z&3LȀP{v93Xdž1߇VՏ(ېyyHo&fjGЩ6h vA~6v|h72>Ж@p} `D4k}*F*pn a!e5vLÿDG794'nUfv/ӡЈSA&nC2K]ggX;%,iX]pPa N!7>%_b<|1PC<1E`.[h0!#qT٘73c4ȶh;gvk?T0X.(=ܕ h`>7QF"J::` !EtMӮ؉|-'S>I 8!{-WԷ^ %ʙ;T4^>qk  2LRMMdr!v'_Eb!iOm2ZaZgve?\J|JGjOHt7Gc-]&D\#+;Utf8~>x9azŏ'p2Ϣ~>+ l ֐=x >OP5:I&HPFT4MW |ULUу5Ko˚&m`=)[y#fmbepS~ (tXZrʜ (gq[;k=m039"Id=g= ѭ hPE{~q/ 0@8fIRߊi=/:CNN:pŤ gBJ2,d\]a:3Ίʸ޹,eT#Q=eI0Z%uq ( ASUt8o6$`!CCDMHCd0;.w؟@2וM_ïHTۺ+|#mwsDau/{WJ+"qmEԓoRF ` ՔRq ¶EXU=Snߜ㧈\|sS\ X!=JB\N擂DZZp3.S1\y OӀFG'/TX"Zjc++kmq-E"M.=9X+*0fV&Ʈh( (d*Br׌Ș_(D REs"6h5{˫]rsg'PktrD JDC}u7C%56NIp0A"c 0x⋈8nhiAZ`<ᄰ"(V!yimɃ!pWR 1O0PέVbE8n@qEb\ \4v{H0qW_l 5Gm OLrnm 4>Z C1dD'>Vnɿy+Qal F'Ry<W mq2b%_U>BY^LBQ* [XS)boGdLnc޳2Ð#8sDzD *ܣh!Ob72#%xpCαtd8ثJlJ#ٕ%sMʂ1V`xBaш y E8GfO^QDt)*i9w?1wt+@ƞ\N zdo0|8S_#h8p9/`:P*17LaӨDGMQD*zPBM,I#qoNS d3;^F-]Ypn>̎XIi@qXgf,1Z^@SCwǑ@xSO<Ɯ7Uj6ݢ@2 7I#M}>7_q4! Ks@vOZ-?spd@Zr i4p6JjȽ6s{MVG^H9yI;^TS8Ҷ!٠/ AZ 񓿽Fd ]qkXz>xH4-n4,Fr_#aF\7^W baʑ=ZCm|@Up99ߕΟa OEs*$0Fŝn~ 'DQƪ%'N4zcg >.WԚߛ(J16SR(,ԆWiw'XԭN{[AU M ,HE1z )J j*L\:nDJ=a#X^Gx-Ho%V܏-Evu%M @-yMe=,V Hgۈb{l dAi?Kus3 ։\`ԏ 5Yd+WrKWI*VpAqn椾}[=IRwl 񣦣+^։iѱWG9Pi6djWCK$MA8"ܠTyHXPc=bitfucb_Bؠh`2z=pXF{-KmxD'UgQ iAc;[[1uſ& .z͙~tz }x!bBST  djَ&խw{Ne+}*QOUaVyI*j ;w I(;!NP]^dy锔_bFu6PzmMC?Cv-avL5ȊSwr*Nnum5or#\ż\lڒF7/=i:mpd+Tm^\^lk!f-8((At|j/HVJwdzP3IJ+@C\_=W@?SF;n5|w@S 1?Ne<0StC] Y6ȼI-*_]M/VV,Ŗ~soro>jGӿ#$?,xE lw FL!a}8wv\#٭^&[46v$ GNJx֚%<HEuES74oUN[n*K k}UCwL֦F#sB4m{F.8= .${fTȖ؁v!:;<QB'|$ҕEHf98f[4Y pY5 ξRy|iLZ-v6*]ssT2 uAcrqWhC/걒Y@#@H1UE<=ɅJGW(X1QhTy|ϗ?~߿£llD>f.˿P)D05(4 1 AìVA(TÖ"23|ċUЯMp*FAoxbbNJd3ư%*"DbJ4&jk9'}9&/.v xlJlRB5pu=U$g@J XzlZqRuBВ/!7^KVi)ʀ柈B5d(IpK[nt~[% ;)HS$PiEV)%ɕ9&+\cS{CRH,EmCUNojer)uyRF} IdHppx?:PXIȮ7MI%ztǦST#IAQOAȍƴVU[NNΆ$ZG%̃@p]hL)Jߢ#t H0F,{k.시`t <]N.>j2U՟6^j R!8/eD`IW.Ho5꽇֢ZWèiFMk 5-\5Ϥz?eɲgg,iD)yCW3~P{~}QIEw~a, Q)!݋1Bh%yy8neE$a"ُƑ+79^Am BcZf҉ -vi sc{ m{x}ivF +uϬc8c0놼nViIϏhEq#,AdJ6ߗV[DŽXX;T g26v|SGT8Y;g^L} `SLnKdCˠgdi( q)]@|Tߐ=}xz!l^j+nFn kPQʹb7Cm/X*"I`W~&O^]5ZXz2K!`H^WQ3w˶7$(֦ <,y}LGA'=ʓI֜j̧ImnU=my3DgCj jgoJ27G!H@dub[_d!n.l:x9tAshp4M4C cqj$BxS0pu*+CކNJjsʆ8S踀$-fQV$KQن[F%+NL׃)RAMs%RlEUUk%9P NKIP*v eFñw$+.~Οxg {vGdO)r ZAvGK ɥCbĪC^5c9d].1AOS2ͣ+᭣bvo_*k)TK/i *Ars0}_MݩZP K9_{P3].c^^E 16>T/Q& pn0MB܆=i9K?8LdHv>I3'ɒJ;(l^m޸o^&VLq{f7nVX_dwo/7o,M2k"!ď8CIxO .h9g Qoij:d ݧTE31vHq`*[լ dv7j4_No_3b;3{6#{8*>]3#VPnvv&}x0h|Ԝ]@<Ċ0w1q2WF~],FAOeTsJAe7ǔdy,$B覩*h fRTPf,4RHǕ5h"@(UVV ҏ03L߿뻻2RX〯Gismc3:6DBnjkQ Psa+?Fx@?O2"i!SE)o2Q;EGS^RF-rdL8Bퟍt?0g* A%H1zWioȘ}6ܵ^'4+&1-WO +К:HiLurl*<ҕs"&K֪Eq'"<~0@[2yB*SD%H"jK$P+YONSN(9ئkV}SGL(@wJ ,^ry Sn쨄hfTބg> gX@$ަetd7?&qY1alnqNcmʱIzۭ1joTQd\2o_arZY3g`nnݞ#^+vq6u/B :!%Ǿ2m΄*dQGʶ "/!Ap(w%*<ɨܽ>kog 4Z+{m3SnB*]=RZ5AZ{r*EC Quj<9NX}oc)úyHog1yzA{M}v4دHrSvKI}H)lDŽ'#fL)&\MkU_!fgg ,LBO8RbNNjNnf_+ Ύ,;&8Hou 1?Wo)78صD:Dv)EDu}OlBg{x8nʅh.鬾D1>gd }#wQ|ЊdkJ{k"'ra,MURF$zOv5U`o3«7$k䫜sdvW׺T]9;y4L[] ZڳKIoWuv=}D"چ~c^;! ҒLK/KYo[3{Ӭl0ܔt+3!UŠt [zkPD:\DJTzAc)D[M6w@͞cnX!] 侻=E>uZ'. P)5(+]OkosyM=0@ҶؙS Br[Tι`])6s'mh67}5Lbv]ԼG\? {m-ub~^ Q\6`ߛinؐ*^ԿKΝ,5K&(x6QEy>!{gٜ2' ([< a Vp!*QF7InV]WM(6ʄ]0b E+P&Y'(Ibh9Zi'-*bGI0\.沬9%N)F*9d'XF"֧^ԡYK$< kDr7CceCf'm{_1p$CLn1W:߉3L-uZS% &z2낭Cۚusʓ_39Vø*u D;5>.,|gJ y]? DY@)\/Cz7} l}$-fVoi 4ӕ8p{|qVttu@E \D4ܷm^J|kW{v.%x!b)}rtSUrҊJ+9?GK͉(m;~S(MRG+bs~U\|%Z2x?cXMqwCgF9iR]K]-{O ed k\ لX $F/8rv_;P/;29 e0CکE%dGz GEpJD ~ *: RoA:dkԬ'93T&NN `_I~̜0fMF/jg#yNhbJބ>fJg?3 xX4#7S=yŵ5s)őN7xʌD9an{p\PLiC!zMH51,q ^<]sa#|bcon!ImvنO_79=b=M 嫴wb ~4Lj_^³e2N"VϑCANH镤E|ji^(aX3>@#FyÉ 0>9@$- 7eIH;Oa˜.F/6Lʉ5uyx`yѻ$$<:[%4RK_8zbQܗVTi^5;^xkrB]4v~&?G_"X٣4lfɚH6rׅG/C_v4Җm85B &K^wAV[Zې 4Yt;fՊ|0I$$U0TZzq0ZY|c[*bW ioט=H$lrW˱К[0_&#ߊ9a K#I)̻Q7S@V֌|Jrl^t~#k,Lϧm;Rw0> 8:>)!i Ӻ2bCخF$gH3 '?"n}6U^,܀`b勢cu-3V,Fvjx6߅4|X)^yn>7XyޏDSx λx5.SyB+g du$3dz8$.Qv#@P_~+[?U T皦sPD I_ $Ph|_cKz}πyep\L;]~xnKtȖUB9prԙ3_ά- r°VI*s'1HrDUvG܃]X1>(ՠVX#ZDxM 棁v7(g1u +FJ8K ؗ][O?<)wA%%րd 4. 2Ŵ(ٶRʐKLsJ4ЛJQ>uz(q! xJ{td0+ GWx%GyޢrPÛ٬?*f' f io봓J@íBSH?OyTndL=vT1L;eY2`eF4$*k3צl=hn"īԏusF09O2K:kG)6V}8(]~ U3ޚ_i\)q_ §ss͔bC6U+E† \ *u 5zuS ^ Wl5!>bvḠF@#vףYOI (oF6o7K]aF:}F@ȘSXkVX˺#"-)Uvb 'fqukR<՚$|r5#jsHHs`Nx[0[zv`ӞeW ={q =L+muR}fn'K<_5up_pߣNhn4h3 4o`fqpsYOp.'8/lg<~g"XY8;];lK'fLCQaҒ 0?(% YK G3-8oV6:#B CS`uŖ*A`$$o3Ș S}ZoJRr.֪D W`;,D\p n&-x$ͩ/[./Ņ-`.N岳w@3y,f*2n](sO  {GƏƟ]/.m{ƗƗƗŗϯ]%CRpCƧ~І="50'x^YDn,Cw)1^҈?gĚ]X=9|bbddb믭+'6^91?X8?8҉N̈C6!@@V14t]7OK əJQJʏ8R*ro'C[l x"9_h<$wh Ip~hc_):H`ƹFJz-™nƱk4WK0hJXv/5UKK`El̪&*yFaD䇔 k%KCjCvGZzT1f4;r@,cܵ+=𪨖cgIrSjj T BR4 d㊚B~nG 2Ei6&D9 @bVH" M?ы1!A(fR*aiSɬiVGMo6T4Tҹh,62I_ӰJИ(rDi""gzesZdmaQe>3>- z-bI-'{tvFb"zR5ђ cg`OwL)8)F5qss܆%-o% )L$͒\3~]ЙfEK2 J %(\FQ DxgĄI-ص՘\nO~ds_uτ`0@n*'C\ 8"&|8ʔF9^q)Ua*7{&|-EQh'ɺ&:MnՅ .U<7Q:f$:sY.6ѫؙy5*bF?]TrQLK6& r654 s Wmey+r-}ڤ~k___w^+H>pHyLjKvgp"iQ"YJ=嵂m~c̀9?2U1G< 0gOc{z]FI )h,囒L/RMbZ$ iC:h 4::8npӉݦ,][RNL2[F#{nޑO4 h$Cv>kY}qdm5A$7`g'B7~ B7wBڬgY4H/&t#Z% :%/.h[?TPz[tK5hԥPd٭ Rs%ʱL}9cRO֖fۆ S[G^r,RoWhDon 0a(P ,6H$]>6O9G :lTMfpzAq;FzxD%TI+="4ah!HR\}=l(1zt%QDF) *."tn* !uDseJZo΀2< TP_|4 qc >xէ^s1r@^T>& E4 )$@z}0f“S`HO3tqrHۀ\(~bJS#Gz/fR@047 iFUɬiFPӛ dMpRʰ++vf @OiX2DG쭞 e_Yt'Q'#3;AG1*`ϑZySwr:[Ys?؆%z*z[\s^@r TܖTEE]x\f\ ϯt^4b*7W naE<7^^^?2!?_,G.[G\~ ݺ+}vD逹o7^?Љl-=)@eO#IN%-b?vm/.rɫgϮGyۇrx97c6)x!=Ja[!Qnv< VMꬷ]'<ݾz훧MpXu6Nu6˿ݨGc0աw>穻lK+[prGWX!o߾E}Cu#"g/_O_AH$>v^zſvܹ/MŘ~ =V~@˓ t&CtX*HX^]~/.߼Ž7nۋ 0肓 endstream endobj 2762 0 obj <>/ExtGState<>/ProcSet[/PDF/ImageC]/Properties<>/Shading<>/XObject<>>>/Subtype/Form>>stream HWˮ$ WL]skd6s8p@!*Uwl[<-Qy?e{a_ ۿ{on7=)=Vo)ֺK>T[-/^b7{iҦin5=MڞU^ExB3z`Բ7 6k~e#"y b3ak}nXR {@@ 'eWD! 5`Xe(d1nի~A[M;J;aW9j*sݧ y48iE 1z7.uYX5ZWt"ss1EJ&\Rf|´k/B9t8?Mas  EtAQ l>a "w]@EX@An@d08apxW|cE'<p> @aG0QTI3:BCZ!vH?ܖ1Q@!pg.̯ zG4:BN<#nZce6nevfFyIvP;/ms[BFiNhNGҰ5Z줄+#)iVp+"%!)e42,leM.F[IU| 8+aKPU=/͌bQ$d>+J?$UPk1zbQwIUS"``} <}&kodF?eL͒c>; 3THbY&ĩ8J0* 8GFT i֣d & km'z[*E3Xi2yҹ:]o&ʒ?Eʟ-, ?T+E^Rsi07>JV{3rTl VNv ]XK6a u?<7GS+g1`dP:ihnԛjq1 njhi9v*K{d;jlf,f'%AS!Ys{Q4T]ZR?ܹAp*ҳtС(Uܨ7]XQ֋dWȋnr $(3e.*oOQt'"3ΛklNGYUM.-0Qat뤎Ι[\! ء1Z 5o?`˶C隞88! ZlG'8ͻtIQ˸(Qx}LjێbwGn{HG(eTEԑeٖso+2~+/ ۞P2I/U'kMqoca7/( ~9qՐFnE3õH{m0b,ymtFI+i!tD3 gJ7dI ma`+!:0`\{6% 3\!3̷2amTt#􀉾|ODKY\Mhe7ph7Ugf5M`#L_4q}. OHa@K||c6W+|{F,~GNϸ(%*UW% ϐrؒ[(o:tF q} io'%滺~b9w%6۠UӜv=\I& ,i. [<Ȋi]I,CR8 %MthQ˕Qu4uBYOdF7agbRm䷜:FIxߵ3/Xɢ1gN&.LGV7Qbj;\y21 JӇl !q"Co;*i0R.;V_;7@?3Z\| *i (7JNfwr餴zhP&+n|P 5|zͯ'T\nӲR}էVnmLnJrlWkKWY6NkYk{u}ބgAzv ޡNi 6w! |f߭Rvld9=ZJ SsX*`"X2Jq7lz%=ݩiMRT6zw6#E5r[ZR|'PvkL^Ӣ5Ho}!T8ݼJs :/sy_܏e)% . / j]ʏKGV~̷O*SYlt2g'iz6kyꜵ(~' 4cdiA)+h@{93U 4Cjv ^/%e5z黆g+m(^~r4%oyFyk->:;N(EL\ox=@BWC!4d fCrnV|m zBLKrb* ewj_=YN5/_m|IG!W&ezdRWUy}{sQwv6=_=C7ٟvsB<X2}_m8k1/: 5y (Їl2&F?~#IA*}jþK#XE642n>Pt٤+YR!r^݂װCy^7@U#d\7,Vy_? LqVa .-0 (D\YG\gU*Be9󃊙nPAѳ 3`v֢#%+O\\!R{ j(6# F0$iL %`r>%cuSH)e1pR1 7>yڌwqes IY:яa_GMqooǔayz}Dy͌sa,ljN~'^ShO" mw8CPЦoV h?oȠGpX'ne-5=45clTŠdxK'3ި3̥WCS`b7m3UJڴRcgD 3T&YrQTn:89mn=$QT[CqLr ur>SMV!Liakٺs/#S'GR&DZ[!ՆjΑk*xg+=wܕ]wfs!/ځ'J`ĉq6b"U/vPyE[sq;2`Oo\1NeFU,=nw;{$QψӊyF\Cp/0 cp= l{xm=kTz a4 K n7 7}=+_\G6jmy󤨁: <歊bd"iRx&AM]Xr vh$|2^Koj "6F$db(p ǭ[i${<I,n?_Y-<5 :fL_ ZQSv)^MP-ZxjIVRW)掱AIAũZmՈ%shxu+Oq9>"c+宧b|FʇjfqϹ1EKsځ>Y;ciͲ,Gk\0 9m9zu}F t=k-E~3RGU|w#?euhA{. PsB<9gNs)uZ@dWh~?DyM+/Dϙ]Hs! ?$ʲNI@~MtT_GaM<?1QAĦ p.+)h0SbrȞVG&T{(H/[ZB젲TN1YhA@ MgM5rv]D|SmM&;n˷m6˞.DBcr׸Fb%SJ+- `N~sb>؂Mt>1?WKr9iN(W7CB˗+r)<};J9ӜtY'QB*1OZ:Te܇$^e|+S;u/Î5WMSFN#*(߃*<߁ﳼ$AWXѓ|=r08)*[5gtG?Uk!｀kA1b9;=[w\[8QLhw'vP@R<h_0z,}rD/iVtK 1EdH-;8\L ˪wlq~i/"pN8\+We{^c9 }$i~h/W2]!s*FEi=`SͻoiSe!Fsi^pիbmM7}NѕyRc_k}? _1^ݲZ rJ;Ylit7io˼_b݄s t}Q⋡%*{bu ( wyUn"{e Z5\Bs.7Fè Rd{PO,2m:6yДxz^^棻!S8WN%~dz_׹YN(Řfbia7 *([g a?lYv; ȇ'v!#QWGTrhpX|&ZOQ;ۦeH=hгϝv'@Tp )vvC_9 t&4yy*/ɺA|rУ5]>F}{Gq8{Or)n3{.Ѿ­$Zygû;?' yХCqwԷ`A-SgCI6q,|MqΌ9!8qܥF]3VLR̷(,{#墓xZ?[GZ1BX|jy 0?"X=ћK޽NėFPc[(]>p{=Ҫؕ9V!fےe%Ճ% C"X+ ͗/BnE l&D %>8=9(!Tj vnU dOdiUftq}qA]6hZ xX3bT:YMt9AtRq,@cdl{;XBۃҬKV9kC7psRMipԭA1[J w9ڞv[mčy'3_WY,$Hʈ"P5羖 _ĞoC$2Y\t(58QWw޿I2wDnGocsA.7%‚Hb^X@Ckv[5ITiL^9~]( llyO<1g};a![g:!{TkwvOwW|f "iwڳkuNj*Lc Pi(YT𐊷#~\'I@'Al/2[ EX"@r;<׳/A3^E#zּDvM CEtNwPV?ur%S&+3(}>/T۹hwd&# 9;{h7D.o܊Ѱ geEWuU<ٕ!Qe_0:u%"ojrgXps˵>lwPcWXr0c C$Cw1BAi )({ŦyjLOgo4EbIeGtL.'XEw.w1I>P 9֩oq 3;J>>,~4 gGK>V& Vl19Tc;R-G_B&1~ʫKg>;nC! 4+ IXqSz\e6+ ԨA7Tç'{Ut]S!Iw>r(:= כFq(˲O+. g;ɡ L͉ T:'* Uy=o}RȊÄ, j&p6#Ƚz~17y[wQIb靯Uy(`=9I;fĝ-~@[F׽!/UG|3NѠR㹑 IG0"  GŷYĖJ)E fdkk%5P}gk(%'LU NC+AZ+mZc(BEq+SMylq5 jojS=[ӪB[D"ZvAQ 7`#}ȐxrGZ~ηaa{Z8JpGb ?~SݔЬ[ھNtTɼűF`,BIBoc1"eJ'8cM]"uS5ek=K%V~*^UiqT6[%ah#ղ-wGZn9T*!!CoHdC0*;c Mr{gvmE_X's nZ;=%BiBWHP-bva1޾)4~3g'X.|/-SEk`AQBJ4vsR5G%V\ڏqۇ  Zˈ;DDb',߾e[{iҕzs $ 56%XP U7DJ㶓^UpɼfyZ%Td_ekAIZZ4Zْt&eS1֢B@j}6f.WP>Սf|v\G(_9E`2=48ZW #NhecZ!Y)>>j]Cw[#Oy ")q̑5sF J_5BȨ:½. GqF$KW(zu< 6Z'風%> mqm лH+ P>7VST84Qӎ&;z&,#+mK,W*RHX(U3l")tf4:Ons_x4NAY0'-{ZL7&IV:RjMTGEdsoKQ?<=*b g&h3\(5HRۮ5M|w5_PC//WWxAw4VԔ^=Rh(S2qRv!3}F&Zڳ(iEz-FاY(aR-ƹBAw{zͫbVj_R`ij ^؊0\mlK{JzZH6QA]nwDjϹ2dD⋫ɢASD/7v&"zgch^}*UEh2@y>A?==NX; E"Dק>K܁ s)j sh#Qc ^K\-T8rCCd:`(h{2 {m_U|m@IC0m +/R.@\G ×k\10޷T!-\Z\W̊II):rBE xʢwD4,T\\Xn`K uK:|ҼFH9D!Uo>}2814Ȕlq."RPDDz\QxaDPW4Q7HY jD+j+y›&Y{\ѹC 3GHs\89%s sF ݌-"F+QQd"fTgaRkT:P2g̮zS㗨mVM[=6AS\2E T*/2]c 4F}tV6(], M'xƒq 5efĢ15Nʀv,qK2cJ^LiX뎟ET*2sm5 wJQp޽Nx0U<,Ϥ_yxA_@MrE5K-הP_.Iv8)tj#yf[} 3_i6ɈL~H j~I^K_Ezv3we(naJȋVĒPwy!h#9:7~M.#-lXtIddED7Q iM*nUL2uUr諦V}iOȡgK8~SOgtNWv}Qqgghrwh-3B-_P3qCloH':Sjϕ~d6WץS^6f8RZVŰk7qCYZu(7dVn:yP)FI>4d@̻@\*λ|20Eu<2 ҕ*(Tֹ"=ד{|ڙMIk>lMEsk\M'1ogi2NYԎ|0^=?UdKmU20dc2bX"noFb 3_5iTe/Eg 4a˦F>_uÑdnB}ʝMˋeۤ pE-<3|]>wܒ7-֐Y>_Y83Pg/?P\ߧJ'yuBᗲ~?YO|?LL84}s (hIG4 Cw ;.׻Ombluhhƀ*[:u wYJ#1;.xF-wDn4IUlzCM/7cJ}&)TW9IޭЙɘV$Trn q6_AxLSy#"Zs=jaɭ8Q( "I[8KO$25XqbX51uLB -\# ̋C1rC) ą'PHe̊1$Jddrm(i1kgBʹaZ0]0У!eF6 !&%LbS8ө5/(q"} &#W=zG+T/\^rw{' |<>Qu@<FP?GXZH(&X+Լ.gaZ<+ Y)$v[IJS=nr'VR4g]X␕qC_;9vef\/|'O}Y\cr@ehRE􍙃 ͱJdF3 U4[-ѶXkr=RSA.*jg̪0Ds] c =kIVu=OH">Q'7t3WiT؊}5?R%SQXR]Keh a%Sf!Qvz7sDa8c e]ˇQ23: iޑ^] R7O-yAB›U؂X2)ߟ]).$8qNMg·J.٬4]rT,[;A|K::OikoIo >Q(O3ڝV+e(riIG.\_3"pW%bC8.sY4{ޏp3NUp]叐5@;oa>0Pfoea%yh:O2L0)AO0쀅7̓ơ^@ qqP^tx.W~FXU06GP ʈ9dK͞t7Z@Y"ԮiDK΃g&},sM,Q֭I:2}ݪ/O2,H?-JXNt/O_&IF ))gtc7(uV}0 zTngpsxRǷ'&ȡgDg*YQ[q+P];GQyxV.T*L*?j5.s6f^-2!I> (lK%U 0Vcvœ}k-L E/X%/m.ݗ_F[ڵZ߰k ,jZ* ̏ojbae\;N? v#r l7 &v;boMnmfˢEXY劓(GPl&\hcgw{1on8zi`J\ O0&*)ΎXW/|I/iPSv_څ7ҭ }Pw2l\k~>]>c?c?d|t{ob_W' X"soZ@oLkYV 5Ҳ8z/7eW݁To)S,f6Ҏ!)ڟz+QfYƽg<Lj"+<ƪ;ZtbL[Nf~1:Wv !F+[)n 2;J<:U>t@Vg4@H]o8Dz wvn-ͨn,u2|˽F87ktI ÔOp<3ٍh˘P_ܨ59) $.yiJ%}s3vuƷ)Ĝ]ōLbbߠ [~~d|+ӛ7В[GT̜l_WuOx9fe yT;:oQ|BNYl^Uf08m,}"3yװ:uQ0@,B&7MLHj{(2[i+]-|E]?㈜!;^G2ct|zte0Cпuh0j"N BI>xJFQo ^~en*OɒrYP3 %Tcug.llW G4ke0ӯͮ۞Av( ĒY(e{jIa&כw+:C<X'9|HiYsWZg"%1t"JKXl˜ yygiH2QO?IRNqB!W†;hRw(5l 6#,+br)Su_x\n&_z4Jln[K˨@}Tk׀)u6[zxQBL]U\͕줱YhM4/;MJ$Suc y`tKS>@XS',ȸ\ztGLvQ$Ɨ< LaUD0S4SJָO&uqI.I:zf9- ݘK&sI,hNkt \_)F'DH*g4ZSS+b,sq)y)4L.i0ڽlu G}ekrOy4!K5b̢Cb ϋ`&&*hP'0o h'L&V5*z!kޟ]rc$2򫜮XgS 4:~KhkMG-cyOh6Q7ɘ"HE UR ~nsg^Whi`iD'?( "B'8<}<j/W 1yAtq adMC)-s"̬CṠ1h.6vq }Űa]mw+U`E-$ SvSR3# $v58"*}{!Et 8`V#̔0^%Qڒ5 pKxNZşP^WNW W=cpoa[-5JJɦN3/>ZHiBI,:'3}VC}w%>Pe$ Q7B%AHi?WyȺoՒk*LCî .rjѓ0yiA^+Su֣ K's"LԳS0MHMTc3c#Y|0ysҢ\0#(0`O鏢 V-# R1dѪ p.38q'5%dY:+11Dt1/Y^MӅc@?qLBi-_\d EUB.2TK4)9.EH_(-FC*{V\h֕'ژ@}*]![\z? ז9\Tcv3%Ք {=y0 cd6#^qAMޒ웞eR9I[]7Dl|X"׍}FnhG̭9A4mm&Ʀ2K3* *y{¹'P=zF pjSP#Ytiqtq(ʒᝉ4@QD*~||c51ȺJNJeEh~خ_FUdEɝJNWu(\z\HԕWSq/A`v)ƙgRLy0B4NSł)02O/|z)РI+J!X S',r <)٥{AҸezCD7,|Jpk^0 }YAbRVtx ݰiBOo\7~D[ ڐԬ@g4u5+CQ;ᡳ d8% XeC`n -C- m˟8vroВSݥ58!R*K'E(rT вS@I-DM@zKݏIH ܖ3PX ?dJ/ Jc3Y.IS o봟6E  R(փ3U |Bf.! ˻xGoK7{?4]FCf?bw:~ \(r#x2.ۮ=B~Yz! ~h0R8Vޝy}iyVθBD>g]q}FE1UqXo[`e+ձ}p?-b%sb@eESσ@UNWU 1&y1`#2dDކč7Mǻ~;@d=\6@4&Y,l]֌h0BsigEJ"@ĠkgByZD%f=f\&o~sqp;+bZ,w» SF폄p-PBVau_+:k{1#rLVt}9nv˶n>9`efk5+j!=uv&>Imjڐn{0{+!5x:ά'#i +K|*]ЋO:HpwqK뮝! 먩B_;$Zwq Phdc 0TceN?LG (8X55 ZlJH6N< às[x4ΦE kf_E`Ma¥ؐ H^Z5,>1]=3Z8ȅJ>wC<05hzU~Mz.y"҆t^DѕX:wWeZ;\ۘ?h?h?hѲmݲ=ۿu`h!ZdǑ5JgSO: ]柿imeĞkmaq݉C~] >M5'憦(8/Vcz1e| Dlǧt֎|!,e &%DT5CKR?٪rmtRqϣ^YgV} MQJ2AÎ-UǕd#? ?Ȥ= oZ+ Xp4'Fc0sߍćNu޷KZZ@,Ŝv[eJJIhv,cҨh WuӽdOl];KطkQsh c'sfgP]+xwBb\|7]|nź4h>5W=[ Zȸ*`顺*T])1ԅ0d.¦^IeԐ"ML\&6ZE#WFxJ۟OpQcs *W>wꊸ8({!uNjo2|E[=]R9pFNYHQD&BN1 0%iw헻(?0Jo5.&N1s\dvGTmkl3e },1-Ld%8֌!K, b"K)X Yk%( =֗;+x_{z\ lW0Kl`#~yQ8b|vԢg(sSQe[m{w5$1iˡʒD"[#@1Ph^8=fR[Sc(]A2&mMIsuwk19v{sljP"~YCUD:4Ne)5F\w]#ؠqpt ܁Ctzex8<5URcDU+1YXSr,:VWɾHKB)fP5 ә8WY9&_ %!9/=ܠO dD?w3.z\Qͱ3_N{ 4:ײTh$a}7#lk3-4w*r{P2Q^xHXmk8gVZrWސ8L2&OG]Z̷\*E}xBwScINfXD $/TwAP@#3ۂXdD-X!]3nm\:7R%t ͫН8a/Fi;c$,?^\|.GQ. ҹDR9A s0%%@*q Q3Z&f2@'unl+P*ry.M h#l&!0KD$e,RmvL֢M*[W,Pd (kCE-vJꭈ@aɥ]r A'MMBk)rt qJ~$~:%nA&MN /K-%1W\>!ӓ5ˢf:}#]]MIW-WVwek)!7›BEU2 ;KǦl:߰6+.vW}HmBoY,w»P`n )ϢBF EB 5EXsɩZvq2sq[w(VOD?{íEF݆ORڇ`^Ue1YV}a<_,c0c<_"CeV:^ʩD_<[E[t^w$Zv=[UF6 C>VS|)x(Bz RMŦԡa#rs.7)O67AtP.kk.ĆDF*ֺ.Ż=6K4ǢO jposL7rϝ @3vr3geh;~޶Kޮ!W6@[eJ,r kjnTh /b*ɑ#G_}y`Ja2T. zÃ.1q^B46W*+sP9?}w`緒ƅȃ縲Y˔YSfqOn5J\Oo$z6䠀!ZҼ0I^bU+F-,'*C l`]s ~+_"mZ=3y1/J֢췡Kڴ[K?- :mo+/hı$ܳgkCD Uc 1cT@e40XdN~!, ~@AA(Թ_Ò]'bqGs(hDNl33GG7.~Bfon/x奐P*)ھKix f͚eN%Gv+-^rS5RUNjF){^\'h8ec:^_:!_.P|^Jq^]A|jc'ki3EuoAHq#AY}GcH.µ45DqH $ɭBT%a^-*A' n5J&*err=&S:g{jx\i\CSDN]+n"R"Y=TT d`kt1aoZ,YwYj!{T=uˤ)}""mC]to"&Q^ɮi5y0H: 4 |dёYx[q|=HԔ2tC`HqMnUM@ܷUM'6h>"8e޸=@X4 ߜoY -8, kĢJ>iY݌K5"]24R-j a֐XvE^Y5qEeT0"iNBJ4+C->ozY*LΠbrI]KޒO v4F)~ 85XHLta-䊲EfMU %Sɚ9xHغ6zh2t5GyLWȠakm Jjdif<}MUϖT4h]4B|:HLR(M]*%-Żl!~H/.Y?X:IE8m=dR1 ҡiJèT`ED%y-v,w[$fff|P^#|\RJ{=PZĎU\NY]%iFKrP1>جN7?o m,$`)e4UBX7wNPޙJq>,ωz*g9|iˠldW<[X7KXq9GTL|]('qqs _Ʃx8œ)NU(SpY0&iћ@S}Yz R9;wޑ@ƿ`_׀W ;˫~5>EeAÊ[&W\p.cDBD?й8b.(S&(4#s>"Ġcy "VxcDZ4 asdzJ/8 xj p@FA" @Q2%oβ Ƕ/FbD(+:=-sl)_?VfO tLqD?`nikpTlEզŞv1*5LZ5ϧ8><ޞцX͝0QbM17E|9@1#JQ2ڒx(cܻ˼%q}at`1hX1$u:P87{TI*nPOTfz Zܳ)jfO0Fi h!:KcY%S$X")TlSY*יzRH2e!8JE!G%Uc *U VnBJʒYgW Z+!'ԣ^uܒd|M,u`LaSO,)JiiI]wj^C܀륇7[pDeJOXn&AG[1D2TWo7'3B~Ð nX}|!gˡ]TRl(J%В*fg*lؖ,>*Q[^,K3Z-IIcS|VfQkfp,2#7&d=Ν lb1Imb!+*p@;xG9CP*Co>30<@c+sc ;m%>4FFpEvEK0U{ 9䦪IGwȥhI0_j6D-ʏʏ?UΓsON^$V\FI{B]QR1Vu2cpkj 21mݟ/Qz8G Q81aݍa@&{bӋe-kl2qHۗǷ_k#ԷR#"O"X AKpȪWT8P Y.TI*/& pi"vU"ʓ!sv)v82=lr$#[w˪j/MӅ>\g oKmfkJo+5ID:ĽcAl*J RAca{ECyР-b*t.sy]`hFhaP"QB@m>ik'ō9GG!eR^\\>QldvD~9@XT`4;ᩁcQf%^h)fd+3J< <6 zM98e4NUyBuľCmt)c\v#L* TS)p <Oi>§Q4 tpXة>]%TE-\|#?Y>6?,1Q>'N%}Kx}z.e9E2iiNd yQSuJnypՙ +v<[]lVj V_á5Ln*.nG6i5E4>b^[CAKҳl9*au=~qHlQmׄ+Kڐ묓ۣ++BMi H5򟮷]r ^ZNp=7VY;aKxMijT.rWe6]:O!7mc D%hp{y2 (N7492Qk e5 dM6%{>^HE]͈h/ k Et+Hh-Gc\3+]5Nxy^,Qy6;(3*Cv>ۦ؈;1#8qaUbxh@K.bҍWԝ{cbR#FR_ݖ t ?J2.#ҧx"AH`T2DT*A&*3}zMyF?yܟVӊ|ZO+iEVZ`u? }l=VE%^TѤ:}`)Ͷd1@9 sVB 9m^,j9ݟ/Qz rסZuq6u2޳^NbŵV Jܗ^Ak wR0=–9XȂZI`"tFetTc 8]d+p C-f2j8>r/b O>*%c:SJ^Pld;ƄTuC W֑c}ne3--[u%D+. P8b8|#g%*h1W4Ӆ>\g 4VF?o|LKʺv̬1;{,:D>JRVZx$_>ruX49*wID$fuayb` էȷL_(GJpWG{>YÖEg]&aNeBk [Ҥ7Lqy&b$naT3XֱV,k/X`^cÜ ]BQ_H8ulhZQzDdZ3J#AA/)0!G+!UpXk|+k2t2DH3"$bRslAfμ"cKRG VDzG7@Hf#*5*ʳ- W_0u fh[~W!Ά>EmxgG;:+'(3)~SL}+2[ܢjf'־y [ 69"5^fcX̮~2e83"6 0aB s噩f*눟85N:vNq\3p8hl1:7M&=򭚨aսہ[ .1 IZUr]i1><D+M:;yC׻<2w34gn0u Ԭ¥l=!; 7{d|~sx̟991}4h:FIE=*NS 4΀%V"Uv3-#3K`&Ǫ\ózdea=]p~!fn C{&/vB$"3 2I+Ⱥ&mz~#[[փz82t`y1L gT4_ vkcpAUwִRc͒ùK[19PFZ{l׶3Or44e}a;&}lbhvq}@4Gr:^[a<7$ʕY /]є {)w~N^aiƠmU"N_&_N*ۋ2\=/K⭲U9}Uv#F;d<(=aǨy;`Z%R.MWJ6'DBaA6M3mK2qJW7#X77^e(\!:~1#f&ί=F)67ũWJ&yH=بhWϗӊl]蘥eœ]-׸YMLQܣ~g{;jX8>;i@e125wn]{WY6quczMp?#O%J{D6}6޺,0i=< (ar-RzRbxcktc*О H[g2{t'/fWOm aюY Q˫nNcxƚXn|kԱԙ~+6C:|<#Sruk6 h"YLgS6w+*{B .#U06t+MRHU Yk;-.YJqݙ7kfLnslՆ0֗6^W0F9?o'APIz:y 3>t2|daBLlj<9ܚ]aa%#soh7¥b/J/@nh%d_# =Wܣ6 'z.oNuN9 \^yPE |a> 4.Sʯ', XWHjM.̑dKXRLdM^xxjsZgMuP} y Yƒ>E?hâW9ӿgѪkU5ϪV@|]L#N1Lbw7@3-x gҪ2_.ɕ:U z޴{S'AV]ɞ;.HTIVQRF_XxZCtM@m}& )dG{ךAI2"] Lm]x?#zv9BFI]MBH},7"jg$d7'kiM ~Z")|#P`Rm;+wSEP #c^ ' ][o#1ti{甂ȿbY~asxKFd̐nA@"5OIf|?X[vGmk/x;u0\W4RL%P [0kt8h.p E(6*.u<+3oީUXݻba^N'G_Xa$WbxͳRywx>kG3=p\kHX@,o-M $Yy3\Qv <F'JJv+G?:&K ȟBH.0= ;NfGZ~F7hFGj>Q>|h "c g2ǯHT2qgu~G]q/xuPH;bPoj6v\}& S?`{UD-8I.0X U-֒ks@6c)1rkRN^M\2&#$ ‑:D= x,;p$nu4e̮pC`G|-GjU.4g1 >*P}-#2/BP^\yk\J%/t9rS׏,9WEUv&oײ87_&]iW+ʲ+bcdJ#̄a'"~G$6Kgd7Y`fG>EߡeωG_UJx3j5V \z{({l]wW+ѧ x\%HxRF|A_ْ锩`Q~8Ua7yjQDL b'BkP[p`nЦN],LPtq` P]r.βʔ3z4 2FS&_-KsQ 1Ll)ONK tkZnVǧ-ޓs<;i>G…mݤ[q%"{\;;b4ؓн~sg S< =UO7s1[vxyrAp'g.'ۿqZ_fvFN5%ZPr֛I*2AM!oxt|r)M(w>ng'ڣJ+Q $+fƅ\l CZgvF}&k؅ І V2("h0aTTJ7P¤Dϸ+گx;3c.H~ys˾,q6gF#B(C*ʦoP 5mJotY:HV X q%!qCw*(F Vv\l~Y}>`x!+Nyg-")x~(ݛ`5*E9Lkl}=PEjp MHS .]b&Wn&\j-bXmI" #gARj^i{U(<z֐훓ʮh}PM B-o N.>(.F(yG{u3`<ŷLX PX V *bPؕrCԲ}üWVenV.9M:D[P>%us *{6c|ǻJp$8TV]VN;ٌWʲFg,xC$-Q*>#U2 46$2p7<\ڏxOsA|r!l)Pb,[ر?J`xPekNTt~ai<3pM zf,üh/4ܑ}[Pesc/C+2T&9Fut#!fwl-] jM'PHk1E;eE Kuwx}U"6uVF1N`UL6Nh*2(8eｳ)wFgJy^LG{2nz\bҭN?W &@=_P9{t3E:e3XTNUMsQ(0քy\`Р>|Rp~QD1__BѰa9q3{C1z4B'9kN|@%*%?wLIyrZzIrd9Cu87EM<86t?'孀gYsGdAZŸ"&ժ#%1t"n+r5h:A:r>rE|JqLߠP~묪L}%ԩ\R9:D ͪlEb,Wv[GqyxV.T.L-U~j5.s6f-S`GS6sNwvnᐤkAx Uq%mmC%U 0 9 ^0c$Zjum?+g8K^\/ſnϗ3kjcg|î)v#ϝby)#}c_n'!ga{ p|f]ϸܔ!n@dkQ=sGҌ]Zތg8]c s^mPI-BdNzb=7ۡ +l1}R ٠"ب]L7;/JiK6\9PXE{3Ȝ7%U 0 ¿4{n|JgRp#RBj%]T/3HE]Mw :[$egC']b\6AJn`J\cyQOڪ_JJCNȈojbae\;N? vGX(Eby E3A]ܡs+$SڦD`o .Sݼ"o9C L`ÁXLaLxj޵3&8쫩ԙZ#?"#?"#HuHkwyCEwDnsQJ; ʶ[m_=YJ=Yy,2Λ(? <9=]9]nq:zxt*_qbe >6>T_6-UϼM߆FVA,&W hX t (ҮqGʣ9Ak{.],'c »=qA3 FگEe!nf!*nisP], 'Qj-x3LV{1Cqqqw^cɺ )qZ| 垟 e0c j i]xc&T%2Qʣp{)NRW02!H#,̹w3O"ޱAXտneP2gle)}tXͼ:u&*$ G4ps!}m)ea+`Ij:*=ԼK&C~1 ~X;(뛯14P}I{{FZTQ7icFc|3ܰYw5WT;)4T?qxDS:|1)ĥ'X Ϊߜ{u+Y:A='P}gzIN/<$gSG;*a1f>/fީMK(n>9#lp)Ph5| KEվS8  hd_f!LzBpp Ort{C-Ī+] )5Vq[ߟn;f?ß?Ö^w+Fu ynɲ#B[zii^;ڵ P3.CY]uP;'O)ba1y߇!p"Ώ[۠¡iuhx&R)cCdKG{+ &Xyt|A :Zh@Hn$p̉;ڛQXe4.Ji,֚ t0 S<4Aݠxɞn,ӅFI0'V qKS*I﫸逵sߦsvif LbbAO⻛hwϷuzfZr:IyPײ}\=Ik`OȣcZy&lwd2G=O>pf=wrZF6" 2ɍyJLv@ڎw{GgZ"EȎ|1*AqG^ :m>=G 2{>4M{C5K' $G<%v շ /?2LfBSɖrp3%\ձZ)18h_WfWzvF`w|bɬ{jKa&כw+:C<X'9|HiYsWϸEJbdD ).HE956Yyy-3`мGgS1s c> cR𮝞w^C?dC?dC];>;ϥU?aeS[tNL?!ȹSk:c;79Pc݈W )4#o>D {O ~C~Ii Δ4iBG>D <؂HrY[2p¾nT[ |YWFm4,\D(/KY mۧ 1'>yG 4FΓßdAꇊ_(4sdqMr9Z=50-z޺so_v? mtu^.w4IV w3FADjeEBHثJ[ߧ^YVeE>\* 5T)u6wFQ@G^Y먱\^ vX$ZN+I{c ytSS>^@|Osٮ .2N@LVQ$Ɨ8!LaYD-SCJf?|yvǃSrItגW5ߚ SP]܅)tIm4RFK:h5u /t^ߦCkjjE]Gdgh9%3/%"mF9MY=7wwjjQPv:ǘ^/&d柲µ93o%YZ>H~oԥMDkfDqbDtIO Uvn a^oxMzAEG|܁E,3Tj«#} StHsz,EYO-:T]g79-g0]qS~~c7LzKѠ VV?g,lg_1P1*ȴ T~ L@p@x,Jޘ<)ChxC0#K`=T=^A!_Z 3ɢunTiFƕP]y-tlTjo*ӭ6T+ٓiJJjH?G+d=:}r+)`T(_['MFC"gLngWc.L =ec<&%"j(5X9d!TJګ< py 0 }Kgϲ_8FBMY +RהQΨZVdEJN6P8HTUյ-?]TNY{`I1e IR&Ճ]`0x[)РIЖj%zq|OP+$3؏ ]$Yz7ıCTOp0VQC]@蒬05B߁W 1|kN+*<.X2Ʃ%.#jIӸrno`fԉ !i65#C*pY9d7c qXj;h|8ĜjSSvK9z dWCKgX7iI>z ˯ -|Qu=0 sхMK 1ԢOϛuR=J.LE9\ Y,hoq"@* 46 HA34wp?k㔟6trrR(֍3e(oryK|w0={u\+#vJ]wO3J,V}ۯp"VYybg5 3@eQ< Ϧ~v9..uEAH?ILU_GV[8L-A0ò%ؾ;8x%bfޱl |[2"A*z*fCc ?XstQG.q}x7o_DY,2dSDc"UVe͘s w0v6_RUEql RP2QYw8RY뭯7z]vޅuӅȑ#+ ,sZW<K o؆zFt ]=@*Q9Ͻ7;HlȐh]VvԊf(Q" 'n >uRO}SIM,M8K!pf-VؤK ~4z߇ (4*fxCu0R!qT#ǽ|2񤶏NnyzةJgD߄OГC_9!UJdGay4^._!j,o|W\e=M_T|I;OoW &UlB s%u$ẌRu(.!&RbӅ1eK*gg,֦nϦ&*r؋'WǴ{0[rl+eE)z=~6Z^%±ȉvjXGG=v8Lr+NuCn/ڎw~,ɑ㰻(Ql̄e@eVU{}ޘKwR)Q|`yڮvsepѕX:wGoj ϩ/R=oPo|-hF?D'o|-Q-!Ȍ~-+dV4- ܭ<{2&(:^s ػ}'fay6c:p°U8_~?꿟Q%5ua.K% &Dg#򷢪\" X򃭺 ڲ+h H5{I>β<\5M 86E;f+7vȏY4'( X@g>\e9WK2Pi})ŊUFHD=E,\5_7=gr=}uѾbޑCv"njWCTz7 ]ЦrK7qyha`/9W<~ Zȸ*`.Tݥ1 Bi $F,4q})3f QWo8޼3HT4su۹#@PWҠ/>"^\k$e ntI&(3zͪ嚈o(BĠjPǂ+̻tijRQդqK.&M1sl5?R-,eŭzsKc|F˅u18ZX0kX3,2,jдf,Ic+̸啽D=,oa3}ry 6ׂ6f^={$,G_'Bft3A^ɛ*-]!S<]Uw}>CF*|IjUaSKڡUC(S^集3޻rI-Y3CI.< FL缸ac`8lo˼S d9zlv6ZD#ƥ¸nz~~N0"JXI*8W:_5>*‰2<%(;t&id#&,iHd~mi~d2 ʦ(uȥ.J 7]G~z0P)H,)Na6ҲEA 5H082Ne1} k-1.(1i= ZFMAV8!z$=YSnO@^|ɼ6TDD6j 1DKM8|]('9;]?RJtL c"v=#;MxH!='4YvIsNc G+v&U8Pleک|%z n&]76몺UD4ue3Vk?Yž@]cq I [53Pcn3Nh7ald 1 /uY'lPصgm"ެ)}g{x[M44-Js0 ]C4!0>fl,j@Th"UVp1.BK %l*`!ټ@Ĕ\)wcs0J{LM  4k5CJA+5بwb$rucͻ e\j; EZ/:Bԡ*^1]ܕdGNUv*+#N8yS)ENn2>8&[IArVcqyR9^m@~Wl*edx9hp߅LA }^' ^O/LZr CaqkKn?ѯ{[zLeW\yF |^EPnk$f2jaHQR4i/Y|SrT*Uh[rfGdgziG cI%1;!,;n>oZϦ&7sk.E=uGX?ᯟ4Jbr )=poew :wƕ.׾ t5So]_9PەDHM:GzJ,r75wTWa}o|-hF?Ŧ֏*qe?cIJjI0hK#/3L-^g W^z%4FRB{W]-0*/ƮWkmg/W&؍X#蜆M\H, d+޷q2WLӗ,FP$ qX3db`Dô -}΂8'Fl Yɾ 9WsȲ/K=K'|wPyD"@t[ 4rŗ% fxS b $Ży"rroQ2 # `s2B<9V᜹U%8B+L^r||F}xlf,&IJ1]Lxl~[.mqz6Uk+5aeL#ˍ SafZ6B灟IM bp#!A#i!;H8ccFc}#q~t.\4+ T7=dתS5*Ф(ߚTģ'.W蛣PuoꕝKw>}U/{%| CrOCT]ā.hTӇ 6uokFRR𾀌ƚc' N@Ω U ˷K9/Ip۳l1>Nh ab$ &߳%<3A5SuqLO)80Rd #b ؃KTF˭␇O=`\|!YRQ졧y}۵a;K7Ȃ, ui)jy\@{]DgCk` ^NJ]u`.-3YnOzٴ*b&g\R/g}Zδ陋[m u F~RU6uk\*zwFqg!EbID%e h=.ZA{*4M+WjK$|D#$zE]+Bm >!料׬[,(n=;OBykZ?Y-]#>FvޞD~ϔX2hPJM0G N+u8d"-JqSO%9I(5_I; < V~-BK #X@qxE%n*enXdQMqy<[ƭr*Dq'#nU0D{FȔ ͼ[ӚG}[=;=PasT@8{?3\L^H6Ys`z,2C)kW2C{  SS|O'SpB3hА/iM#omڇmtbaOtlGrK2xp̾tndW zccd b\(qʳ֧P$tbjɛ!6kJa^f$ҏ_w>}N.1X 矿F9xhkTɰUN{ZCV=e5qn#qGdyYef%?Oܓc쓴c Sܯ5v$z~aZℸ!s{lTv2='O/&=%c͝_ꀴ\WJ|^Bvl.4e[ rc}3v*>abt1F{7=adhN\v*}CyZI%3VDZ  B7- *`E>]@ROwBA#_2(]k/vX_E8WPC(cI." u4DxcnL>'OuWk bƒ'k<|rx|zbY2!z\Z" buû:QkPD/R~kg#̡eaJMcγc +$r Gs`9Y:RAGgtcE7"g`t墰C._7%kxBmSz(8%mvxVʜ]ya8CRJt=P .ǔ4Fw~>L]ⷕǫ߮n{yzu`!UMۦjtQ9[i#c⠞֌6v=br'4rhf~$ {w4.z^hT߅ F /Ɗl#vbfoÙz(1{Xg_cWh-ܦJAzrZ'[ /jUp]O䋾 ?a^V9U:BV4g\P˶=g.16kVE~}`Nd?{"Nz4p#A~P qPN~_g2Dʷ@դJ,$? is޽5-ny qt{qTokOO `ػj_<,|u*r_WʻbÄ8޾=Õ/wIkŁW +ӓ})έ*<8\(H4#-}jV2P>Ym+'ԣ]7KM  lZ3Ljj*L~ {4`RlstJkkח{$D K_??z .W D[ْ[1\dOۍɉk /q/l9Հ$?%QH>0% x`!/E,Ysc6| 3̷jYV[]&b$wUNٱ3f)QE2 KJ4LUueN_6&`;Λ{`'x%ZV$&\-+7\%k3ݽnp;.*U%q$XwEkVsF 9J8Z**.Ğ~]$6:usJ>H#>#I'!^39IM:Y(3!2h1 4qѸ&̇IWhTnml2l*C܋]8,RMU/I'V 'MyxS|=_)=9nO> 6+PrF WE!$lq:1bu_ChWqmJg/\Z\Hzg_⃼H!5drqp^U҂`3ˏhqlk*qVj?xeUP3ϝzUVkym[CKRl8*`>m+SRnt^ T5Y]֎XgtdEX3# +c66I*埞b.yZzN {^ ` NpkrWƗxB+l[4"6@D̍NB$eD&(SJֵn,@-c hbd`æw]5ԃ k>>CVhb c cvCE-G*Ac\%3+C5"|Mq|+XzOJU227AddcEť0E*<#ѕ-5j쿒^ɄI&Tض4Фw& QYQF.Vk2ULG>D3־ۧJ)7Vփʣ7{ = 9Φ<:ae 8|yy׎>"5ÒTѤ:Se1@y! .X㭄M ۢ11!7:ZC5.ΦM\YRit'q, AWw\704: ieYP+#Z(V@5CEY:Kv 0a:ȽFv,| kU.%c:KJ^Plf;ƄY*f ž)+P gbg3繶yHx,3`_`̆İ`S= VuU>4Vԗ?ub>%]ef;{,: X"`%y6  DHyZP˾'ޜ}a6^ʍ^Z4_ "CU#Ѐ*P8,2JEҶU].ΞC OkSxSzk>_z>?L2;et2C~g'1~N|~cM pyogo"Bdf}cӍ@'",R>pc)! i= p)1caK"IJjQdmd.FAJ+LTw̛np7SsPA*rkN>˛Ū-,% MebAD3e. ?dϟeU0+,[?}D/Z'HȽIEnsY}~7so>E7SFHGO4x9ezQl65JMOy k#-g!ogGAZNxqӰMJc5E`* mtEh:yGb(@z}aȪBcErtO5Och/@wԃV!pV C0qLCW9^1"#F'YvA&q0 M2=][*%Q="v-7 =n^]ek{rORy\r{=@Ahyomj jK&Y+mBd¯9ZJ׹Lex]EPTAYe|JFHK#Ȧ J4i/\USbllHTS&֖3xp`hIv#m]}?Cy#P/oP2+0zH L8Qrk=li ͹C;ɉ%}dfO>6Я} CZ(fq%3^l"?Ձ\WI,rڼ75wT/X~ _v1!bPo;'+?-t |dk.)ryge~ъry-71s9hj :{tnfV@O_btmMK:+Z,]Z1%[˵ cpwgN ji};ScúQGjIχciL^y@%GΛDH-Ξ[Hu%:vE•Y$U;;jBq YY}[*b4=]E/p FJYkB~iҭuw_Ǝbl@kGސ&p Sv%w\K1ʪ=! P0vRQ;JUO$Qa8%c11% Li~'Hʺ*V:%~AbJ}1Qj筨T#8%XX@I!$AWeU6F`B囌\ث^he,: f}f[*oAlJ#q SE? ><=h(g. ]T?2de @6YE҈:i \86X:j8dO"16sfHTlR=]SY6YEm啤SXǶKb<ڊnv99dUxk>$y>:YFmTM̈́GXC)'8hkMRw4C+Bg'^Fn+Q }C׀0 ï0 ï0 CFaHnW"<ɽi׾?Wdn,>9a:68LprCiNL^ٸ.N~Z}x:[(m7{!:aN7" %Qwv>-N` N*V|Y5Nn[[a3dwbo}Hj-RK݅6lҕKbqd $+b΋"rNEtB|;@m* Z%ES7m~VLobJkJ)wBeI 6P*֖_ؾ. 6=ȈjJԊ65yA}WDcCKGlx~A:9H\ ĢqsPWjiH5_'TqXvVfXRH-%(8eXY%GI?Jm&g*LZ ]p[=שT)GU*0ϋ4v)u^񽒇2ǎ,7UpX66$i%*!7Ps/-[" r+X ?9z\'<yvZ8.*YĂZ!pf \N}˽ ̬YgJ:[BVƵ/ ԍ-诹uSu8;  'f Ն}jډ ÊݟB<)*ٹtxםDL|nh?+u\zW,{kO_A#,̧n sjM'>jJv$X@R֤ J@(eFj^C@LJ>=R2VAėy}i}۔|(z">#I0F 8 ' TWLTύCnls)YEc=(#{]1ʾ㒋P.)o"#Eo`@V\JҶ]*ΞC*'NsoS:Nq[MXxؕVpf( d͖H>.ma_{ ػ;pRD])'q%Q4Yh! Eh,ibiج? u -yWzVkIdyܽh~t95fG?Ѣlr/L LUBZzN ɣ%y.hBUP$EI?$XUͮD9Ƕ\lʁlnMcuwH=1w׍B]2 (aP4FmLKP`QbcJ8(pߓ!jUI8tE<0`-;פ?[҂jPv[5y'ٽQD"ZroА[=x m4&xNAk/TJE+XZS{T1@'CTђN4 L5Tjh߯vҧ ==;xGjO)_-RҮ,f*x?\3M\kWd."HUoiXXӢ$&S7#kLj>c)dF=.Ov֯DCav$?1qoc(a4Amxo٬7PaɭˏȪnI)*ڠg>\PhVcL Gއ"UHFg_[~E_UD@Wl kV ظC^Mň A AtpȒ4mG6 ^M˚Dyi [JHrEesq 4p40N1[Eސ#z(dngV⃬\=/#ڒXimĵ eRƗwuHHʧ U2+ʩnbUb8LB\|邗PjovnVWO1ݞc\˜(cTdQE=!24` GZcajmVU /Ppi1YyS[UGb y#@6vT^=L 2SaNan @r5$ t1Th!J-5wIPKzof#O|{v/x<<8v+g_,pݞRVηߕM>>S{|J:]{1s g,w 7Np*Tfb{Q {uvit?s נ7a!\wfOI=]*uRk0TŬ&Y Faa5Sālq51@a#NYRA&M:xߓi_Lؔf*34@n|R aYO7ݢl+mk#v0[\ ] :ubw~=3 4 in\Urr`ݳg)|î%ٿ$ \*E8~տ;TC-tOMk"mQM,TFf?sX$_΋Vx#'s(gaͽ^mju.By&] Ά$i[*:m9<88l?-EhBdxiѵ((w,/ZvڴDCl{}~E61KƬI^aAh~ΐ2B`w=bӑe/H ^ Ыz_]?4J@mvFnc3[]9#/VRbD h$9Pxx/>e/]g,Hf+j'bz_37 whMY'.ZH3QY,I !"S&K3ScDdGս@ד+x:SʮtD"AT+84iv>h D00,4Ȗ3ĵ5u#"R""~R%mMyk TZ[.;aJqp6l||G0tRO|p0pj 7X=DUBKK]NŋV3SLQDjBO3^Lj켧F(\ԍx^pnJBo3V)Y0k7*ۜ}62=Y)Y9N ǒ6q=!NS}Ҭ q,qz8TtJq3%sb,`z;[mqMJ~)mP@AtWɩ L,!BkfExT*l$M,-n)fڃT.?TYjrCC:Sr_\7Z]p,Mn$Ƅ$R6*UiW*TDxbМI軶v}i*~/.="#  Σ):B9.^u̦@}}|Ҟ .Ԅje2r;YQ/V=؆ _ m[aM͸ԣkExyZ0ٮ*^g ZǞ.¦E В}elk'oq qڐ>%"hj| >\ML:oע&/(6Utxl\* j)NɥǾEŭж*_q(ҼaV #g6 KX wHZSVO$7,UEr83n\TZNqo`?#-FYF;y frb3$4`-ݖf*tjO\`hSmb:HWS ~'E?~yP&x*LN 3SPG6 Xa3vljWٟv?QJUtVCdUjOt\6Or^$W}ED>可sQqGtWPUXF&>ăH3˒^ GUvliCf3>M;r\T<ՊsjR)#죍DC㪱XKnhk&G20ә{;Y|% *&oN&m@AEb@Y7qp:!W,ͅڄ:YV?,qIl`% )ęy+@ݴ6URCzcTV΢4tQwW gQOOt'%}r`rJ=GoP_wVH|Iϡwֆ5nM4!$a G"[cڜ}VeBUTGRș:x3d6?֎ov⹵M7,FP29VezWIXG.ϖHbe-M3ddB@ɱfR@Œ[C`G ";o. J)]Xrg]q:a=Y?ɪ.rMtmF2ڴ5k $vNT-%gb',=qQÞ&,Mݰ촰K~0/%TлH@.8}[htS yfsrm:̚q=S&9PX|wTKY4L6bj&]I~Q}M ԚM=1uSt v$YxqC.> ʉW j|œ?EIDOh $@xQ CCy>bG9(+1{ JmH1My: #J5R&jӢZMg)T#@ޙSoqPWLSASDA ьrI$ܫ ]'hc炙RɽWtDWB ~<3)} Q^;)o6nQzlT[w5Q"u099l!'4JGM\o' |&׷IpyMG(\\㩃Q͡O(|w}NeUX~ 5Ikdf2W\EwrdN! W2M lXP˰Hة}b؃J}!UY%a fa|8,34Vq(] ĂULf}020}ж/(H0'w쾩dϒyLȘYCDʲ@XVx.0aꪭyؒYȿ;3$(wq( ^JҊE@W,$p}gC*Ss \33@r_Z4n20]eUX *~3X j( 4 vȼ^Åo%ϟrvsi?H]_TKKzU: Ra0˯τ@q v>y#C4oź&Ig+9TF,W%fLҬ"X:0 n4, ."%y]?u8~ *G<=xg(/D@XY# ayRu51U3SGbS3jQB=-Fֵ_{@\u87TK{L x5 \Z%M kRKCy.+ӯ_ 7a+)L.%q0N8~[SPkkC`u2Lk<|e=֫K+V^**s-Z$ȗ+W8qI9Ѥ#tj6/Tջm+@rJtDHQ 鎊CLHȥ<>߭1bh :B R"9ةgq$WS!j~KpHkR3O,bAUQugzTa+ҡDhm_ zYP4)*|G?0WmzB_>V{YGw0~˒^sdi,\ Rg%-v'd]X5+˴Gm+=Rn]$\/C <4`89K\2+<0d:qq"Yo$ќqVMl`vZhǹ*,<Pv~NNӅαM6Yg ljٟ7y5VDRt2!ׁ'fTڷ^{N?D b*r*xּέ9PB)qҭZ™C=;K9ݚT]YQ?ֳmkh2%%3[ ]_=JCRa#U"7nCQ"\=enLb[a}JH]Ypts UB#>O.)I\}Ҧ/u5 B܄An?Dz+ў#;i0E2? F .% 7t4Q4dZQl cj_ h5hJ"Ieￒo\;'sEEua>/I%3VIq5xHK*pKTA{$ϭڮ<+|$#}(@ yv`j=JrEh ?+':bI=O3F>=w})$eucC3U/lML N%[;fKŲd9@MNJ=补ik*+ 'r.hk8xؗ4]rȌE%Ɉc%mV}(E8ToX[EbX ?8e:r3_!h&FSp=u6]9:kJYײ6`x$o u  -SxNJRls  C(8Nq-ӈ֔6Z%Nӊ<+4G͖^&^ x9M[*o AGXwb:@ TEX ZgPe'/\iK36"xwnOѐ2F 

O|RP܁χq)cwH{_}$R ^$6pFSqKR|PW5[Xir|Gɳ_vWo)a%xԛ{L.xG\&P[":d| J[?\ۇت *[6=$}b/ ?gHwE| VwR8)6 E(#%;bqaRp +dmҳjWõ&]?oEJh=X3MU^z>c^ exALq-H^ s-B)zKoW:W%}>iwKz.I5ܯ"bweU-3DUb_VgFkeExT)bђE+/Cf,wRclalLnCb)Z,MMdve*fƄ*质\VD6b\A꛶6}P%9\/=Ǘh3=d=O|H*Cg6R FH^:!̓iB8wT6A/LzPg+.LE7= }onlGVto_om :Ue9ϡ=xzYaCRkfiЊڋ"|@)`!Qfؑ`"xXU\U$Ш3e4 tjyҷjmHs&MF{'a`:YL>z{{53bZMY52\4CLf^+PbqKAU)/ w?*?S7 c;Vُ[*44fddj3-|DeGoBj-}n0OSAc(LJ>U0ރ!=}0fqȤ6ۗ>/o{ϧb} ~M.@iYDitɡ%,]b{cRH5<ǚЧa)ٔvMe{*Wo#}mU^7M&@=S/XdC[}']mHcy=k"pS#c$ d8 ysE3]Y> 隲lw吇8va>-0dOjߨ}y~W(&=KV1+HAFh E:K:8dwX` JUPM GOfy_;h}Dz~{k_V#}+vֹV~ #_P&5Q?ݱ|hVW&oprIm2߀$ B/n.A@O `chiGIt!V[pcwo`ո<ϒBzL[ȅH=I`-Q< !]LKB6gNxyv_bރ2zN5D؅څKMF,9{,x`ʈ[ǔ5ܠ%+0>(SR>sE93SV46z354 )=!{2~蕀rLІ>CJ2E8IXxˤ68xuuA'Oo3x șÙ"Kğ |w@ z87.=%7FK"EP! F cIǑqdOg E~8XOC(-N?< Kzը!'tZaj J Bj9fȡeؚQq6ʅCek`jC-Gi tou2wO~EÇfZ>:oCʶf OY4L4c1[&UxlȻ#'. F"K%t &\sschbΐ.&䌎kxI&64m.ch4͑CoOGڬ#VfO΁typѬ㟹4l`ᨌ4tv6%06ruxW!jzz:vC\KyGFu<_ '*Bv[\cͧM[ŕʃCgACi +:_@]UN> Nruc]DzCREI}*;WѸbAd\业- "*M4JoWեO%zH<&bՑ]޳<={cI;b#aioVduh JFiQFbHhhH= ۲H02 $^E;cxG[(pɔ$o ֔s.g~Sɴ "]W!2'bMflCVObTFx,k HȘn$*ψlH{ SK3,Kb҂aMܧ`\7Y @ q^N!gVlZWduD xߔaUa-(^o9 ɷ .{ |CW@ѝÄ d͖P6_Ts$W@ g횛J$b7HKA&l' Oct{جtDUFAl7ڈ=e<=ً^'% 1/097H%EݿOm=q"Œ)SHԶɵ${INUM~k6,T_+_%8`hL(4MhFIӌ {>Auzu뜥Rm%SbޑIm/_ث_[d=uI{Q`NR;]-U/E:bmp1?#oG]㨗͡ehp^1ޖ.[ҕS~5~)=wRڱK^8TӱР%(c:SFc&9HsYx_ȡb  36kHZ$8V9Au 4$I'M4),N}Vgi6bͼ d X_MVES#jTTQa~Ś]~`i&˪rYTJ(VG[+7۷RR1 vsiپd;cUptJkfXױ1A,+SQMܘ&075b+̸_ b9лnz D\Dž71z<${ykxu1~Ҟy+=? r8+єp*T%Jz|y!Re8\q=z x&W,jS9 \sa9nKʗWAMƳ,Zj SNff[Xսtt׼FMcۚ>1 JpSsTpbz{V?a|TG%|TG%|TŸ:M1l_n.CnߍF]/k 1~2>u^N~3rN}Nˍy}쏏?a ~XÂYp!7p5^KR9&ߵQi ^ӱؚ呜C1.iF, m7p42qum &Ry;82o쇥:Qwc կđ{a[rl~ýŹ xp{ xk6E Ä5kCȋVAyڠ5gfD̘ (9DLRe* (/ZF}& NVwैPK'vM#?BƮT &Dtg յc\c}7?`UD@j5b͆Ѵe1Cmd+pP]'띕[8$JܓmJB.aCVy&O x ,{E Рe/qm=+ g8+Z\/Ѹ,>!|î%ٿ'Hms!T; Gyq*23)~[|TB?oK oHdK>NsKl>ߖ@ΛЛ>4u4CL[_9-UzY=IwzP ,AmFwY:˦۩5ʞ)Pybiz>,Ym'_͗d\׆`Tę+#srEp wj@j'kqV?GΊ7$xD!3APMzgR,&*No]AY[tOԉm|e@ut*ӝ*VM<72@\X#/TK-x{gQj\*p L`GߤhI0<"~4;H#ζ^Q ̆l2jؑ DU+T륾-PVԮWܗ*=@<\IV♬H^hm]gIAC&3T14}=~VmIr{QKET ngM.QERCd k^dTrz%eHDŽ{chbNͰkAδH@ɤU†ە(XX͆Ȇ|íqX,HL8?jO΁@+.^i(iGpNFїf΢@[E?#Pk6tEh~?N; ^ Et+t2/{\cL?[=ģՖ.Bv[\f'CP"-roJא(!}~>{7D6"HNXxNTָ]𿞉Е-_W@1F; yO]Xo$T1@'-$22(}':Y6ҀTt!RtHdnGW>[CyNiz/'+ozȋџnc#hȊX}`4638k%W?w~lq{>d!جDmhv5DdQe6L~u thE,dȧj}i>xOGDg*4Kt>Av9VP6 b選F٨9$x379U֔.=H6d_5(׆ZTkSfp>T_B2;~Т[ { ڐ j{E$֯)HPWu1C70"`}2LZ=n^AHTo}AQW°/RAԸ9#<'WtrcHP>TkC>ŁQ~#=+AUN+ZlRetCF^;guZN#Dj!fziQ:xɇv!th鹥KwQL7 T2ٺc\ϗ&z VdFUyxFG$~*R~K(cd"5`xC,UjU4 }1LZ`LfFVԷPX6,05]aw Eɖ!_p lh!Ժ]u]%JMG hl+cyx^8ڭ}"rYEGPV+5|>}z|S=T?X=*p:ή?M,5 /Є cX_U=pҔeKT}; #V~_,IF]Η!&ؖڀI)y|gKe|%KĆ.L<ßD/Цٚ<؅Q#CX밡N24)!)I F>'ɰC!a6<9n^eDr5)6uB5%4Sꑯ%2W糏eZ UH**'Qj 84}BnP:ev"?:I|rƅMsk*oxi0-u}A E~\-a4)NZ6˜H$IEXqd uSNkZ Pִ}$\zGUK8-~[V~xT"~Vw3_kx`wA^riܨ&yI9p?\ MF/ 7"$KKB'$ze5n^rot_i @rn8ђ~XP ޠSW !wPsEP!0FSN9dOYzR{0}ByQ,'MY]$BM^CL+U~iiAmgs$]j[}}3ߵ`:]QD@B5sfAӰ2z{HvnlRYCd@`[onR +(2e1Y G@!΂>7_#z%֯pT;ťPƵLda]c7욂+l)AHnl ۉX'߳vn? ۆ]sa@o] 0kMAIdn  =O"`P54*Zc:3M6^Y2~o N[3ZXn: ;Yu-nJ2b%|qae/TӺ€Qa}H+=*;Ԩ L~Z&/LMҜ'+,1d\siiCi;/i[Sb>і3Pg&av4sģEy̘Hq>dOGT^uMS)Ro9oxGx^nTx{'_l^tFdL¬[-ep:z=fƧ< ”%ʈ$;())(ib]tթl{kPŚyGTL O-6;Yf}'ժ&|!&+˼<5g07M檲қY:KD+v ^ytk/;.?cuEYǶ풾Gx{e|' )g"|<+MW}}WvuZ}˝JbOb86Zq.J=B!M|d{[;"$Mx0"Ĩ_PQ:ɺ2B_)K y.-9B?@Q<,uEeKtª ibP$@nʙPYnxtY7e2VѨV&9C(3*h ͡DLl%>C혝E澄@/ P"m |v-ID$LE2-7%׊CѾGxܩFuuDDf B:iSlH'DLq˃yqfD+ tTxbHҖ^I/R-E.2DmWv=A{NdBDo8BB"ȓAAIz;+[ "FV!OAXM6Hfغe [E }M}uU7FFEhF "E@)jxPf =ӒI2uxCۆxn텰)t([&R#XA衲h+}omh这XSC\WuTA]FG4Õ:W<*z 7 /d vv=ݜ6Ҡ彫D]+s)T8N)fƲ@tn X|4# >$Z+5+ :&k uJ`Şa-(Hl?a4%O70=tUj$㢆<4d79rI{1Nc^M30 p@I(:XTcmBZ. x(/d!X-F{,DsgX=o9?f,` JzP@O"?$TUmi *|BX˙'$f F"0,"KqL3K#xv('$]Uuqmu=4/H"C#BІ]c=c>bUTW>ZoW꽣П}UubByJ?05CBq )#Nٮ7#ĩy"6)g33[D5OԂhc2]ٽ4LңmiT{ X$ҿ=LyY"OG|\-7w9tJmQV:)Lx*CelJIĎTj[7ZhzN6 #^m+.:/,?A1\SW\$T6Tu~Gݪ[h7X ;YF}62T |,X+Ur i:+r|"3 Y'B= 3 C PcVj(M'`Zj Y׵$*HAOͶ#GWY6ixArxe?FUITr@9jW>@n= B>ɸΗw ϋy?dONx%DM̹K'N9Sf8D"5EO&,n qvd}4ѯE+#yꝁ7n~=ZjmJ,5uL_ֵhjPlZ[tIX : 2An@;gk) /L,Aym9d5k]/: AzIe9Z ^^"~;\.V%qtMBnpE(+P׉dMo$F  Z4#~E#>{f(tCS_E(22&M}3E|"~ Xx򮓊>=m!fSs0H*81%*H#ޣ `|9/k7R ݹ;lA+~% Yu8%~ 2to=׼ndbjڶ*e]=~* @I [ɗt㉶h^uZZՑ1%Ɲ^z|+Yr)(2:]H+Ii Vo6i7rFB5n BgXDIƽe( bZH{'eOiX6/0Ndz)lDRFˠJ5cVt[ESO3_E3u*G&> D|.4;>ye|w|/s,;v#n7:HַCGe ta!쪪97bHvvyy:6K|NyiI=н rNĽp=_FvzlY1QaJT ᦑH2DO[3 # ⽺y"ACḰ`.=KyDŃovmu/.yа.%3|͈ dʋsVoqK]28qew=s,Pa0y]*f?ٷ'ە0>\I4]aJPs (/630n^!uuwfOl-}'e{5[Vwa j͖{1AIHs8C*:rx]/(:*k,I{QRfs%FDzQzn⋈/}EѵnFz 井z#徾I"6bJ5Loz}Bwyu*0wy5'WH׫&.Ổ2׫h(\7u8dk+ƳgssU3zp{x,o}WBE!$놸\"$72sN7j(i؛|5rI[zz+DqGqyꭷDN$ gD>=WUlIKkp`eөQ:nɻKu76&lYjc |!,wdX5NT& a+]u46mjY 8u=4 [bD=q`d t_㾽Ίeѱ? QoWl"gؚK6[˖Z>tviWby5ExJj1Eխ؛>/ ~OW̉#hYX\xޮj#Z46lz.rXyG"iO)eAŻ_Q#MUVsb-Z@B#Tު>㧨bo x%MxY:Vc\/iB5~4]8%3jeFHQG[ Kߗ3zglk$$-UIFR?CuKfpM*a|a4f7eMi}c-s ya"' j]qleKIV$,ڱjo|U(I2<Ǯ\nGIq5ߞ+9pڕ˄:W3% ɿBMdu_ &PXGEuߏ[\?MO8߯pmsbmAt5Rh^!fCJ,MhRVUՠB̜6(-.j{ffsI~}c ֹԫ nEE쯛Vo~`i8nsS *5A4q?gz $I>{gSxPCAD_xZ1vrR/N"i$PS8 P1dطo1 zy_'zmJ`:Q,]tաѯ u6]5frLDXQ*0wV&/e3T1@ ֧GzAt5$V >.1QhfޠfٖoS3e&ZwL|i#T0=~_Z0j.%~]L)[6ԨDIOU: խHeșur%5[УgQs5.ky|Vt1Psyj jG;ʝ} <(BˮݭUJ<עe,2h&7abc lj=t>>>*يc T1ce:~mڻ~U調N)!Bx>f'c߹{zW^-?Ju[0u"[0}M;"NS~"re )"v쌥t]-)-uRVpg:$e)375dZ%PgTˤH/Uu^2N=t{M\Re~IWiHa9R_%աDփ$ 5F>e ?JpjQ#َ5zRF怾Wc%{=%0< 4˒`!he*fzEؗT;UCUFJw.&UM4m&SB1TDLRE2bCSKSus _(uhˆ֞ѕ~;߿;:7}eZlUrc_{3]jY@Fwǒ5齒c|ֱx /3¯3 ;yɬBKޖkw[w[5yLdJZ1!-CN+e:Ӧ4*|Yi`n9|=nr?{s'"#b@%6b0Ⱥկ5RK%Mю,:*{ O-!W UO}jRw3縉u|QuS_4i@OX.i2 7)IӐ f:.AP$;7^c\ Mx1bMϟh,Yԑ 1It_J<݃ D1LIR\RwI(- iN۲G[$`ƣ~Ei$?G"M]K:/b"qS_eTP6k(V7O8m]-<_KM'= v)qE5}T%CP ̈́)eC4T z_.(-\AI8]*k@OF\1hNu33mQ&lGE(NÎ2&䳦hcb] v|F@o#xRDPN"H4x1RZdg˫ol#p;? ?w}9\]#%ыMRe=f9/:ME-ASڗ8)g0k #H#P`ALc4e{N8S#I9n@grD^D+4kksLJWgG•{_%}eZh IvKw~9J MJ'UXгPčyEEﳮ@fk-*֛C6QRLi#hIz%Rz0췔z{Mw= ~JlbLҷGTncMIwitWB#ճ"E BxlƱ@_!r{~dIn@xSj۾z/@IY9ƹ&JL p}#\רGµ?vͺM-'$ӫ-iyf0?a5ǮTOuCğEn.ʫڐQbbV׎)5hm?,Z]Pʾp r1-AK1˭(p)vzGK}gZ˯veYHuz:`וЖ'"1P`)6u[NWtP@IѲly٘o4 UWϮcz!l)C{vm*=# g\d?OH,!y=uhHdm_qA[joX6tѺIPU-7l/]4a@|7^>Lv'9B%_١Uk8 tӘ eYp/?r߷[>,h۸tOn? Fľ9*+}}v )YOKrm/t}W_RIeDx9ȄPߑn#a%ٟ];^,5^)Yvq[O'`_.dbwxU8q*:5+p9#6Ѯ'=>]%G2^N ircC8|' 7cJVy[^Q@w|YvӹyhQ{{8mUb~QFf thfU\DpERG4L>B#l;مTBhnl5 iswEX@`Q3OtͰb:гvQoAycK;kOt9܌pnqallRc!uCR)*o!@OY vi 3{99tgy<|0k2 d@hw~Ǵkc9ǒwrs=/sWᠨg!oኖlH ѻp{9?ltR .љy5DՠNu$RR]cRphΕ7;|tXiן9$o 1n~51Baj!ԤXTV&}.U`|9 ma&A@0It妮yjA0\oSuSO @ gwVktyV_z`.h|0R%'P{)O`M;D>_ͪ]óab]75xcЩ~ +SПrra/JFa+0.:Ӡ ?bw`Z Ks>QZ >3&}${KaQb\:&LRuڦA)7rww#l]>x5ELGڡ΄:qwgP+j  Q: WK}cIr#AT)r# 3 tFE`q7:j|cenހdՀ"[I V:d]zy0.qg!#ʠϊl0yys>db16_Dйvq+Zq ,Cʲ޶rE%|fۙb OU!5cj_.9˞}P^W?CJEbZazc(] WU$@VR_VI12 1{m)S I~5oŸ,{S>픶&$+w'Wzw *WK fۭb PXurClgB}P/5;xJ71*Pgo ReQmy!H V>!0 (eU9/M)f) }'H< A\uר΁NB'ѐeCcN-]CTs ӕqCt:pU8j΀>N邓Jc0-q OyQ nn56|GELJ9F@/ّv9ٱSn94.dr+&{Jwu4@J G%M+nl)Z P|3f5t G'e(>X<' 4~PL+KKb6m}@P+'ơdM"S ֽ/Lcʊ;f8LgJyZK{P( ^Ap(_T)v{s16l8[d gw,NinV[ Q?u|o N?tjRTG4{UĠCS+&C/J/H߶p~EϙS `}ܿyϒ\gIT>S5BNeKNj !p4"M3~Z(lx}5K 'F.%1^n@,cĤ]k|=N@%m`k> X[2譵H<|<߀ hX 9a鿅/ڠ=nWFQ$sхMv.j7roW,室J/d4C\jIm?Jd++Kcp[(N5,TnhHLw> C;r{aٍ֪gD e`}0ƽ > }95zָ1/X^4|tE2g\kPr5BbBIL&^[C+Iᑈg!BawBKJ|v2wajDn#nxPoJFɎ~ *=ot5\s XYLPklh>DTnPFO|[HE$RZպ>=n{ξ`\>ꥢ*'*4%}xl̀1eˎ< (EȪxrz :gG_s|ǏV67y}ݎVbƉXsRܴ-\Yg2{bdN#J;5h~.Ջ-[MPHb"/tr/ 9vN1Lu(5J!(=_Embq^ iF[=_maͫgI!n@, ˒|^_t+y.4?E'Kd #/x$dI.zRr]Tr j Ȯ,07r55^êfS$Njq̩p_!R&d2ЪCy>tZwZ]Rxϩ9ޣ,+RcKe3W3( ܮőЇ$α`#q,>͜[5ti{gke*.׻Bx2Vջ~DY,[a*+2kjPEߧό]RbCS}s68+^}YIdWn>n|7JcJɶZf]ww#Fylݚ={zyO?[PC_;3YdAuMwe{sr'jb+{֌Z>LX75C`~-H]T ̝gW6tEb^a nukf\{}0L|yXk\b'z9sJa ]s޳D,)J\Y/&v h&cp4٣ݪߢ$lx.jBgxbc+w@fX^"U}i47jICVY׶&^4̽0nO2p*JCpf@0]j=G!T,*7 E:g*z&NRGiI&x>~"?>Fs 4c`ƢJ )(Vc_'waH}0܌9dRf 77zT/A(m1>O)k۔;=&`eׯhF gě{e낎J11QM+7hK w{)/rp K\{wӻ{;}nm#lq5Ϸ E0\l!5ZBz_㭾=Ҙ_,FUteL±|.0nR ZU!.&횇v*[7>oR<:x1?Kp`ž}IiϮkzk\`"Ӌ]];mET8rUHMEl?SP;oh v}G5+(^7;x\M9s(P}I-8Ԗѡ ThQn٤w5d!@bمl3l²ϯN{xc~0LjGNJx5dKE{^R ̞c;K^9OS]!Xt$U ] uN= "U+ސ\Z\"$) R.I}?/N z׀j~8VW_ïqr F.iQ3$'՜-x:5coL'={}AY;5eF[KQ^bKhs[>MpKjI4OWsgG"73j;+0KźPeF3jJޙI(IgTM _<J9oRJc EC81;cཊ XX@[CVbu:@s\JR-=.dEAȐD[vE-]E#e~~Y0x=蔡 K>CrY2I2\ =}h/z)yRN.ͻs#ce3LS|T73 bs$BCõ-T/iKd!' IVQǂGf ORn$щZFJKG,(X$'0) 7Y$/O5ιGB+J0>^_jAUH*7ܑD^ gO2_Dxȏ"S/Y\_vH'$X1)ihNԨ|#\+cjR&Jw=Gz,oȺ4̌LXbi Gh%-"ĘxA0ي}ܚYoOB-yoYet͎ {]#%T"<)H 5&gO-!n UO}RVN{)k_s _[odUkG.4W" I.b%3, S`~`tXdtD^cU(2p&3$s[G~ 1Um&ך ȴKʻ:NJ~l; _0q{Ȼl12{;M0 U"osF<*EK7ֳk<oM=gϣ³~zuﴓ6NŽ0- {?q:^~,&}gtW< _ףh=G{ ko&ˠ-?BO J 6ld5& 1 Ͽg;k(99&~IYz˵vD^M?(j&.!i0st~8<ҵM_1J OarOˈQw@|Ceq({@Gq:+@Dvexž.W~˒o" ]%NyoN28b#6YDKqV)Ef}+w,Dʒ|M ܈JU0 JeSO,)IvRjחF.ȩ7v8V XV§ʯ`E+K1pn^BWYէp\jX[q5=k 351.C./gRhU5iIB =gamUs 6TEիB%q=ˆtIN#cQk [F&8&[e3W wŐ2U08&@5&Hw)ZIIMX6H'. rMҳOW@{)j*^7Aٯ[~H2hP%:wN!Xg; uV-Xc^猥qTo-'%|`;?Ӣi5H)<7"K=QklmbK{p⚑o`@>,*iҶ5]*zOڙU&MuPN#ξި#06z2xh%E/)\jз}]az}d]%p%Q2YvUP Kr44ltFZUi[z\Aҹ0*{ÿ]dNpp֌yh("hDS `V-!4Jʐ<ā=7V&TpEXvjFvp"iHWo4|ws1V;@tncMw(=9{ߋa7@ ӅiHP7ZK&e[{sR`Z,PvY?MGMs5+_: b^ Et+0`-;פ?[҂jPv[\ys@voP"-X7ehI>=wDrI',_Ak/T?Е-񋶮bv+Ԫ7pHl1@'C1q1N^4 L*4JvĘN3{Ȳo=z(yK2m肏U=EoqcPlH;AxII};_9 Ήq(Cn?!8lϝTmZ"smA|Oúł+-ZAdFN~MMg2j2'61vU~% [ '9ap!H层.ǫ" JަcX,M7X({ -Z^uYU-ݢHr鯢 &ȷzkiuRĠ+pǯiޅ뤹;S:6 mC6tbIq,AGfsF*-h|~]98h(1њ"ͻ3|ӗĂH{gM_jpk'0@;tF|UK R*AFoMAaXd8嘽TZc0wt{нb\?ڞh|ZP0ZDQf~A_Vr"NF]S%G]BI)K 8}m*oU`R|^uuRP:ɸz!cպ\޺$=Q/ 4"ͥR9 tV27#E&.ִyGFYl9f[S 5߈|5y%sLk\=P9SK%M1_7qԛB(ZO.~ ncغUo}>OE,XݎMf6?Id%0RwY ^IMO 6ԗHlM$X)$+= _pV%vd$2 XukxvnBLrCi)bgzC<rgQS#իbyb >#d]Kw7s;k) ,ETuD럦 .!}Ss&%7CfWq)(:@R^Nh[4%i.E.IoègWw+zK/tO#}% -Y%BF5#ӷ\ڴBϯTt”iL̒qh&LMaes-فe򶨕.;-K&I{`.L!K->xoy:Z !ط/=J!]w8$ar/}bRN4bj&2| 8ffplpUd@A4 Vt<אBr:5ռ|l~$;PtUxNzRד\P݉GOx%=fvddVe4;5^{buܭJRR0G{埚6VFfw}D_9#<${VߑiF;}`_y0yi0oT\S't"5EM$1t1٠G *YBӃXbLddnM 2A!o^,l%F]7JVe…jjUO<ރî.#sҋ|N2yogQ5|g>2h}QaBxSJ$ {<)#VϒK Þ7'Jqqg@w"g~NA͡cWRL MH jDU#G,FP}R! mN2N!˜O%`&ǜHiLMdTC-Psд紐!sZNK[]OzY+vFZ7$@#k9ηkI\3Gs#j*TÓ)$&s?UໜwxGsꮷO[xսȜ,4Χ0fmNI%ރ$,43=屐L"xNa%pHQ$MUx.whc6{h05KL tYmR#XZA|' iXc{=P׾]*Qyf!3%S ] iR.THjFVK,6mls͆ҌM^(ϭ̪) ; -6sܧ _hr%̬C=(;utD ƸnͩC}5D*J\aDj TI[R.!ԳN([ΰNxX0jEm6 93ZFUo W/~A _mB8Z_Wa[\}8NY3B0#*naj ݝZdGhJFf?~y[߂2$ +p2*7%ڦjXH4X^EӻCOE$ْZ)^Qt/y7`^~^n&XnqOí) ЇJ_"#3Xk<w.N^cuty)EZvI?#^I?# To? /} ;!U i(2 onG3r1eaf6˫f Cn5jeC-E\Q :3F2[ 3ԎEYb->(~*.e5% H9IT4h,ӣU`S;N:ssWymYPb}k2ԤLlzPKQ.Щ4̼8+({Eꝫ0@\]cJo64EUbuS !km\xW԰ܫSܚi{xIoEdoWz뺍NplA λ ''ymعa/H>&yCyP~-xVs_;l O?} T-lAPfP.6Q˸Sc(uؐ('ǃSFVΜR"vA<9K >ΒqJvݩssT02df& WQ*/um/gtj &8zjKƽ#zJvT5H R%j|EWz!(s-,̥XΩUbWp 5Qb) U uF3 +O5љ:A2vrJw1&34hHdMt'HYXΡTc]Bil9 Ċu}hwكB77лecfxzgT,{4_mm{YO^T6T |BHY/MB%"Z^A)VΝ}r(@ fE3>g&ءYl2V69 h?Cj~`@j*6#Ep-y-^ov9DŽƈIïIZ-\{]}TC{V\9eyd V TcA ΐS;c-=2 h01k>?z)gd:ɮr,a}Hy&d ~[lS ZZŎpފE`"cB`&+ Z1<]WK޲{7g~VF-b_L4x--Ṛ-QIIW -Ok~T)fn0!xw;5%qȁpn%ky!|m 9[IKVa6]ow<UYvR_WWQњ)j7}@R?jR})tQ4ޣKЌלRRWX;%S/klƔ9 "e?M RNUotN*v߈5gnl<{h}R+3:]zLl[JRÆӎD}>y__=8-޶yCyVgreX S$zF{. sln])ߎ̹i˹kSsꮕ3oHk'P =oiײj |<no6Ї:Jȍ?Ho1 =]v~<@Om>|1RʻMuTk0(J8wKt#ح(SHzfq'? G}Sj$2p(@O+i7n"p}{c}ǣrSQǐG迤u^q4;f(\A,J+X :\E~M00ڭfcʻ^:T ۘԩHFgjPEZI|97]gZ/r IN`гZd}3Ϳ.$"%t2Jh8Kp,Зm&)=-9Cj7z-B0LO׽ג8#6`gIeS"'؃9)ŲU)!C.(W9rS?.Z1YJk*+wϏwSϥC=e^{ðRWIOb"GUX+9; .>UeAUsD0j!;J8ϗr7')IL֡/Er*D >q[3vȯO`[!%,4}gK5PgbCLt&֤du5Y9'zB8]7Ӡx8/aKAT473R̦z2bZT{C_vW#<0>'~t3`!w}\; Iv? ևv(Ez˖z:m %dBW>˦C|HGNo#o}HaU+H%NrneU8\,bY ySPM7rA]\xpAK2gFԹ){ {u}P 'f2e̿s;l=EY#ˊ!$H Ϯwo@}Mĩ3+^)BXuGS V oY1F"8ʎ^}w'Z-a&a] 'E>^jD:OW+9a\ߋloMTY>8v6ǘxN=wіoD>V^zqRJQ"R܊ <_jh-J6^iY][C0'pټ&rLg^1f9H6'}vvÿP̠"(Ŀ)tW`ѨGmȩ&uAA7dWB(&S* >SJ2[̞\!`߷3,qH1O*si _'prIġhߣ g<WTjBk ͼ+ypAil5KnL/*D[H*SP#{7CweE3OzYwyK8DS=.Q,ߚ{pq-U^>3=)3AOTвc5iוp9 iA DOK?Q*m؟*AH J`&#IPi^&pȜb*dE$[J~YZ%IՖziʩ"SW,wzoA%]GP0Vxz%rTE&Kh2mY?`~х]PpJ|Lj7”M/\¨K@F&!q}` VEQk8Fz[bO:qENjKXpn%SB4|.z&@JgT_kqסG"73j;Ram%04)a\V UvD*Ӡ As%޹I XSZT|F$ R{KeQB])t f Ϗ4@C0cQP%"2z<]z>΍#};ﮖ嫰RkWMbT %FH񎖨(4>gP;znQOMJ!J =IUAkg‡Fc$#Q(.iJ-n#T516lay.qR ʅiLϢksG2c)Ssrww'kyUP?aB?/'K|ADrlCפKPn{Lw:1:zWyUZpa>>,~>B-ϑ.ʂzׅ C6 B))$3"X*dRUEBa\J=`_VLzoNH&P%_yUxЅޭIkDhP#{@˙5\r=U}eG[]w!"C͋ӷ·b<+)D3yI :x$^VlRXSB˪դUr\WF¥O2"7tGT lF٭/}B>xzM86 {XM獺uw܆ڴ5Q|xyNYyiZ4Ѣe݊UDJj?oc=kg|[NQ?GPw}fmж OVhx;9[>mK+F0 4A]EMq%}hup -.2'ɚ-4nA(uJ2C_kGtꝞKxP1.2Rh<5lPv#Vw[.ezc !za~p7Ĉj-B7vI/Yg+R 88ELWI )A|%h{uUaKƒ\"" ҭZ[JI)nNZZI!mqN8B :v]5nh ]%SEW^O!&-rlHL0yA,%@ILUidtP4na. *嗀֚AIxDWiJ{x6-(Mt5 ȉq\.l)\3 =Wy/v4xٍbZ`l9y oFOwk-3 :cI,} 13>#vgJI="zdry@P~ |ęnEA.u. 'uѰMeogM,EɑCY4T]y3i 2ڛ!_[S78U_)Yd%!jG(Խ RϷ<ǎt Ǖ \u܁ xg|}(hJbQ\w@Gq2bzL66vØ:k8AL=L8\g|mttENm8[q*}BO˳^̆nVhiq JPM}3[ܶMuИM(zOjidM".T"2N8|fʖQwhB9?5P YB꺌)OHjY QǞe\p=@9Ual&~E#܄G]?DJ=qdyg仐+;Hص+3i%52 #CWʼf^xSqtˮW U4F4"JQCiW.~[2ɲUKtzyIzx{b]{lűZϵh_('yq 95隑5GT''4РTɝ[|'7b㪋[89MZus"9_0-:m&c?l8qZ{OtUI(&]//g"cF09rUd5&r*˛ƪ;K6#EJz-ٷ5rX/޳XAH=7UoiP]Lf=aqX7qsben~q/3 L8D#"ҏ'k\v@#3CTGϧwLPyUVm]-g"/NtYBS7 XSRLՆ)KzLLT4 `́d P LŪdur~Ÿv&駡oov//{D7[0~=m|ǑǑ+kAy)( fqcÃTK3;apFդڜjرG=ӹFK`(\owс6i]& 51%*t2RWoVxum4 {^dOXZA1Lp1k9޴!=vП zOHxa?k~#-24^+sb Urw:]8iq)=a(mt#3d3#РpdUUMvĸ6:rΔ&+/>\H'A_'q s޵1ns)Z(1t*mяF* 7-p[Px"9[FN. t V{~eߟ=S/z|_cYxsWv@qq;D&NT"mψw~ -Gȿ~9r/G:j6?|#0t~.esnqe/KfrGmUiؽ5+^s\s/ 3cӨVhGmsfd֢>E0T 2le&]Ҭ1 Ai*QuwbV(c&c,Ɲ~4T 'ŔRQ^:=e%\*]bKAR?'aaH") [t7 q#JK~\tųWVKdu;Z J*~GDc;Ba ;1RgJnl>Ÿ* 9$d_a_v//{D#Xj+3%&:6Dz'+:<آm,#lZ:ZBG(Oj8EO+M:wr]]53. 9RAR}U:zF"*޸ 'LJ>' NR;'J= py8>z֋* :i9K@ʞ)iz#s% N}i|gg?WK$))Y8lzQsHxiJk. pu=323rݲ++咘\U `&LoJ eckZjTVݵI5ԦOQ&ÍspBWhYJjhL\ ^9UcޑqR8*y9qokYTib42Ws~eHr`8C\C6Udo'jD±+'Y]yUHt.UUW=ڨބG,2jF>-^^6Mk`?%6_sw?VIҕ=wk羅/d6ED\S?[5N/!Ypf_9qz<8b 5g!./w/־%/!q ]|Fwp[86b9*ƾHsqحh6hc'1 7 #ab#sCq냽_d`pO^j,EVT _FY!ꌤcŵ{_+Giq_*-?9Eo w)&l}{ۧY We>4Pe/;Oa^ܵ:rdw 7`<?أEdϻUkMv;㻵wkL4_OIͿq8&/i 9X{«7+Ky{?}v9d%/}!;nsU "wU!d>v!MI#&w.9I_q;1x ю+n-C#EFX" [F;}v[켹IegUEnz9 ^߆ѻOaQ{PDnmsӃm>P,XSfx*oNۓP]-oB%mtՄhA%BoraS 'h"``@opbo>}+4s *Dh`Ieq όBIMC5QFߪ͋Fx~Gjp5YB qMiHք5Cs2 b(AUV>A հre:0 >IF?B}L7Q=U}s4GV[CpDЂ{pud*7H z/x _0e_+1-L0*fJ5gDZS# qOOQxRبQtш6Hek [>zGyț!DF~exJČPZ{v/ U4b1{K! DX68qU'i&Ѓ2KtCXΐ}]Iݑ9QۓBzW fDkLI7K\^HN4嬞>@-J {8ք<, 7\;>x J/sA%,".؉͂Y ].0:) H &5 h ߹‹p9IJ}, WwHPeS-.ڈ+4Ȣ N$DȚ:/ wp2FZ@ = p\k e9):2zf'1F_HU  h+~#6 <3:k Âz#hJ,PHE8,F 4PRN\`T-0")Q8yWx4Z;Y]g+Y ¨(H%7"i6 RN7tޡsϊrg?ԝL4 S`:d冨OQCN|#G@UhAt'9o'[%u,,K@4[XURȑ&QOy u^(v @ ůQf[D]$^8s6A)a_jLp[ןCHCm.?p51eʩG8;|q!T8{| cY+vuB\"+ހ-O d M_yDVNa+jfS35X%^ M[q1)pADe dkoN˫j|t.R ]^᪟I޽T7,vWTAwjK-X(d\G" VE2\Nx 5Iۿզ Bk7 ~BH?_F-Of#I7N Vtg\" Zގ؋zUI 栣 UEQ<@%Q%87فÍr8誏ՐƲ\ROujSPc=4^1N0WUsHAK%TQ+ԚeR]`~'6SW'kcntׯ6j>u X1BmzbX# 1C3 k-32tqo%i 멜?Bbӿ_|;!h놴jNJ53o>]G $A:,|IzsSjz<^B}kKu\<kt7s웱аJ { SthOsӓQZGA= ɩ#Ϗ}.m ztVQ)q'F:ԼҶAt7︈p{M9[G>,%?2 ~ŏ4~-p"Mo0Rg& >+Hf9 J뙲5hŢXC]"-{E]={jbj6Jg0m̡ypjWIn~,y5ւϗQ伮8 NP14H!k ifߖs׿o?k*Gwo'&o!"ˈgWL1ΐ1 A*fEVYjh+=.:}z1bausJ9W٩Lq$X HZ^Zbș.DVPU+eqO0ɇ48>baxˠ68cI.t6 R 8wc^tҽ4FP1B,@3A =tc2}%7~D)M&l*]Q'>^a6gz5 *&%7Dœ3T!=R U .[QD[RGLUkmڵ@`DNJ(wM浂~vN:blEB #"%ݪr e3 vaXgW4"t1alJ9ݬATN r_-\j7xaA땑b ~XHs")3ofyKJ7MdRCfx@Xz2 Jb$iEV"=@ty.f!K `mJoC /d;nν97qT?(s'&3$ۀVѨW66jj"hӅYyA Rrxq9~1qSkNX"K`Qu[) MP}͇[%QzfbYs5ߌ |U<kq%e=u\}?>mPє[|gH:z;DqGvo?Pև;gIf \cljVVtDmO` qET@&=߀{2R)Cg[05^{I-I;dcko$#tf\64#}hnb>TXm8YRGK'ϳx=>nƸ.?L@)P-}X.uz:0| :z[o'z5'6 iэ&U5d'p0JRCKe84n'ИʣtW[!^i'$})q70f ڋKiW]PTU[0 ѓj8A'[ONP}W=پm3a,?t5ADiST2obD4=_R\҂{x\qS+֙*|gx0,RQ8Ӓ)~Gz2!"y D;La;Rz2u?].]9$[,#%0),I~?#f8 BvkHrqlІc]uzP[5buݢM==arkGV|6 +heku*AEGwBD>hi6mi=`5-#ֆ*Ө!:t!~+0|.7wuFTlִMb 9ev /@m]r/4/}\% ܾEy7:,[aЅ|2<'0K _?Teċ9"k:MSYА^L<)ߟӵng74sCVeVՃv:eS,`s ȹo5v^rڗ]2v!вu#\e%p ՚aÎ6_5ȺuG9]ܣŰC5>=JÝw ȼ)ĄnQ6+~I:X^춂ڟ^lE/U~ ? ٚ<>$'S;U|8尅_['"/u]tv>g1,#u*,Z;r& dVؽ!S A$RmzB牙f`+., 3vT1#[.mddűG ^;'%-bJj2F\a+l "r>: lrZ;l \*cFbXY_'tpIvXm=)| yq[w ySS}\JV;[~m߶'a.WiqȲd6UXMzD \p RBw1ՠgdgECo S]; -5Wn( e RP-\}⸴afeX&f3T]~q wadAadKPTpќ'Kk9Դ8Cm  ba|?1;`ٹ~o1[o1/%$ƫF3>zy$wn۩i9Zu;ԗ5$(qM[$Ze=Aij|YWh,B紎x6-6 ؛lݤR_9.oFi(;Թ ջeqf;`.#9Ĩ2UO\)X85i2!!q;+!a/a$gbRHK dN"NnhZ0Jx$RH{B%e`}mpM]1ƥS9VW殷0x㝝eR8{gogB8BڙqB盪pj=D 1PP\/ Kf^6e?K E7J!QM I"޲vܘ-|ִ6v8n|m!5J+"͔Im4~Lb¸<|>{ԈJk6 fy9L#J(VU>&g0g ~|[}kk1̯ZLK@{} \BؔLo`eFƺgl*!O1O/}TyȻJQSS^u Q贂J8"@8C_)d6/_[&FSw]%~5<+٩c%uB}м]Ux`ƌ[rɲJvI^I*}w3\:ޑ1tr7%.]Ax]U:y-eB?Nh7 ND;[Xtc:Oj8/aN;lTSV1)OKiPS˟1KwעK zqyc..ykF%mд|B@7dpY Ae$/m` #xN&M!Z%B%0>n@8G:8EeF:J_8sj-5nGKrx۪hI*$ *1wy)7u[_.96*je=4zP 꾗Gm؅ļzO0`Qnx9;9 d7<|zd9<טrc{ke "'^80'i5Zo<k þ: >A{l՞&'m۰1..ϰ * cVu7~4l0w]՗TwNôK*[W'ne&KҔ09h_Q[jfq)\a1P|ʳu :;"TQK72n8*4 4a(f[:;kAC<1EDn q„~*<z}cpu=1`{b,SHDDRfْl@6IixYD?褒x?`ʡվ?S0Ui&h/UlJט9}ȩig5*0(4 ȴ }`ħ{n4 Rm]8yjXPjhʐT)I.x+u(d[JqDo9#-Ϸ<'j8TiXXz>b2$T02?Ɨ̜ۅ4QЛPO-VAr*$:OUUz a}~/ ڒܤw *}6> +Alq)E1`?>Nmi%mEPE=){\BL:o=d}F{Q9)A>ߴz@ wB*>??EoC(DciU GJ*H3mVLZ T08a,fpO1MQ`&2W~ KAHȼKcAbU``PKխ1̩B)A#iv\ :.,5A+wz"6Z4nZ^R m'_[gS*/S!Eurk*m~Ѹ 3գ~Y4Vjv QRK:2qQ:^zd91/tI-mN)N #Jl7={)J+J ex<4꧝Ti@eCAv{\^G#NOZÎoyGvݚpɺ}S# x]gʉъP0b^w{!'^Oy4Í^+¢c0rbשUTV_Ar{ ]o[,?۩& W+ӤƠ wR`Fmj;zOAU0j_X˩0A1^K![sᬱ+BPdh CjUf&vuz:W׳3+)H`gȳL(%r"ͭX#k!6o8 E*K>kN'v4Mr0]F?CX.IMϫkZM-erY* /5y:ÙB j$P`\KRjM\dɭQDu^Dݻ"E~8CF=JxI[pu.`AΦ?ٸ|G0ap[?VrnzMW1eʙUi;|9V5!2$_} bV8X̚( C/ѝ>Pf[R' r6%9Z_E^sbn7Ԛj@ A:Li69f+t7D[xC "<$`.fhDt? a.JXq`լ52Jƚ; JuAʇ*sv[qlE5E Dq45\Bohy$;)n}[+[ڶ`p[0Wb6Y2 Hp ÂFrɮchZQ*vpqA |B՚rͥvK+#%C[u:t}j>]ZnfgL3%Lo b3$4rE :X.ehS4Bȉ1Obl%;w J(}B8DP$%ՄANe`'/']z"vDSznhh,ߒs(9ZzN )%Z쾱 BRNj0}$WQ$-Kbu[H)'#lm!3: 3q]z~H~sJANxy*yK(:ߒiQ- SFEjykOU_㻨UԚM]1N_ MZ;yA,lAIMel2h۱a>&mϢTC \ YY2o? 6Eةmzi<̇3Tܿ,gqVRi Щ?'Lt;hBu8̙T__^O&`1q}@=Ť|k#}enzVV-XZ8QDR}UeQr( mV|`;?ˢḥHi-QO|Lo, W~@a7Rnzm5|iz UNMj Tqvm,`lV'6=(FyHQD7[":з}-e= g[T^])'q%Q40l~0m]wa31qVc8{.Ԙng臆-J4,! $5-%eH.q` ",;5"eVI$XU͎DmlʁlnMcuwD+v9 @޻b,Z-MCZ2,/ME7X\Ƌ]{#xq WOEg\KaD9˼lف& T[J۪5 dGׂ;xSD k}Gdh)4;pZ~`t{ODW/#7pH)cN+)t%22(c 'D,i@@*j 6(I?һ?*Mjve5cUTkT/"{~9?g$+#2$q53@˳;ӳiG1 p.Pܾ!l{&U#֎\h}D<<ӰnE+HBMndGט}&SF XdF=.O%:GUx7A~J+8UxUDt ⦯RY}o@Ü%[U.QM-dSUAgϼ6lGǘ>k9V%"UH>~EGPWLх%{_ߋTk6ZXZvUC 0lnlhϡ'j^gfho5a(sg]j΍K50šORF zөXua&kZhњS'R}i!Iz+P ^ ѹv]*>'HɊntDFZXtSԠ,4īBï/$uν@ D0+a\Nbf%S4x!%V&I)GPP1dי̵֑Qt[SOn|pWD2WbPcM0\*Yl2q)vDM5[5_zBYǷ[U!x dUx2yA_{)_|_Uy<=uv /\5;\0b'V[_0W1\ݟ+s0b"YIl44p>j0<- t1Z(L B\Q}3 &V1F@exDRhKݐ]CH|pC1ThM/Q\9frWK# q0ٺkjvJWe+Jﱟ1og줣tBjD x^ZѨ"ltkhFήa]NsE3]':j;/T/yBтqTvT]HNҹ4GƊ- k)ZƲcw j.cI@>B˝8uf>cTr?8oN3>X@ HoR6I~CD xcv%%UCK&1Q=E$GǸ(ah,Q3cn1 l&ӻXn9JFskpHg lq(dSžů<گ2D_;Kf'y6y^wnղYf}Zgܫ9ֲ46@6E?j q*W{Zml12SD:o@XW뀒!b<=cSEI̋q,!BCH|iWܨpD޿Dedr IhjfHȺ oϺMS5Ee5; uHdu䦮\ 'vq9U\Q;;kׯw1ׅZraoۨO]duF~D#ۈӄK ~O hs¦Iv'桼,}{Zq<u-S?(v՘9U1gvxU7g yߟ+j_%_s_mpd8%a_.z AU$ ( >vE<!٣3hmL k~/[V35i1nQHi"n +ohlPiK5I`.kGgpiPBs1& Ͳ8ѳ@V 3DAxE?A :{:S'h;O ʅrQ\811K NY~b5`LUU'܈+zUTn!s{oM=yT{p&?F50$ Azg(r 2^>dee'C r6UUj[zGݟ+6[0 Ơ[Guw :"IkدӘ]tH{S8m];fwM=vrIb9А k)ZcKИXfq$ɑ )5,haG K挈 t*dP`ANs"Ï! {f71̠bN/T/qm8@bjgɷCp;.ߦ`v'}Sypgm y\ h'I\blVT,PY2]E Z jCJ"&59 u'MM\%W&nE~HGrF zP(^ˈ PS#}<'I *PU8`߄ G{_%ou'e >C k(_CjQ4~EGw yόvvn? CS,fP @R/D\G(O5$)+5էT H:pHI2mLDJؓD/-bHI`j x]|sZD8[>~ $?4HmTf|;L/nG'xt#@ݽAV _EXc͏M UɗEG vKzOj{iql]Uz蛖U{EE 1cd6a-54a o*b6cyԮg~_Ie2 KV(6 e*2VA=Lp5,UbKmZ(L#~W{Ӻ܊),o3/$Q} tS vD+3Z``o>ՈT ;dTkdh0դSȐߐ"zP#KSTP9`.@QzH[- 2 8j#@m%p5ZM`eŚں,al| [HEuЄ٪lb h8`3]{Lܮ=9?.t!unn_FrVBʨ},vJ_$ˤhcX>Y9;(i?2B\ :siIovjL).L?F(_!~jkB[]xeւG;mX! 2Xf(X~{{_vN'`2oV^HpRT/+][zLmiT".Zrt li9j]1ۦ&Fq|cp1;-N`Q 1$:7.YәkD]鯐`o6&OȠSh:h2NJ<sjz*Qۀyztx,HaH@ a-3NV1ϐGn-Pn\[n1)q#KXIhWv:[`LnQnm{{n:4:řt2:e \St2<՝dQgkgX,bоih" ƭe;_vQ4: ۋbeT+/un۞~),`o$m1I`9AvW3zz 4J^2sa.eJbv7%}`֍<]H._6xp>u2y|%gK},.@ }K*zPHݜ!X#<c`~ ̏20z:@~>Zk{zq AЊ #E6EXH'o/ٜ%/[49f#q[oi"wUi7!u1o.Q Fbhw܈TLݷo /4!PH!l/Iŏ׸FF[hʨHH k=F+Cmt'dQ ںdϐ͌5r+ 8҇ B*SbfδJ +OdYJف62^KbܯML Zf.U|F ,8D40oĵ%FLBJ28v@സZOok`5LYmƑSֹ-qp 9yTtkyw$ʶ-Vv>ƵE9gP8=;ȐdMz؃Ka/EgzҌوFN`f$J鴺GJt (]4"+K%gū%՞u3 iu |҇Ő7F>JST4q^'"Ml]RMƇx~o}C>s?p0%B(65ƽ4}u!<\N>G6"!L2l Gvׄ}F#e+f)E+352ȷ ]1y!R.F4Be ;PTC+,)-;QD։oV3fOC"J'-Paؓm'af}hAXx/" Яί=5K+}')CC6NfMʫ^&_?&oãiSDiX"- 5ԶJh!!};TJp#KqK",z7-nM¿~?ԃ,MW1R'#bD$VE*%&"fXooTE{dI/,[,w6}/:rL:=x}9,G$v Mg9Ak- ڬ%Nez kn|o$05%*H$:o9D%h;|}to$PP𿞂y" "A$K3z!Lľ\z#]Z/<۽ #ggwoTs")Lؕtn\DI9Z%gyj7)3)T40Jr9Y XP(T5qz2$M&n:tETBt6 $qSyz$k,)XnIcC?ZV<Ϛ{6~ <{nZޠ He=_ZE3Căv^:.@hս u4HEc'`~)XfP[lJ#R(@PM)M'֮ 2йIW 3z^~,H3mF4/Rn ͯ7:U7^\qT=|J*_:?1GɶkZȽ!RZn$Xy)Z$6h^t'~l+^tj!L~ lqbhv"ʗT*&2Zv dCVkYk SB("Fx\,6Կ_WKLag%!ڎ Aan2\BMSKX BGdp S.l_Q(.@Zt9ʉEYe4 p 3C)6B<=r|r}k ;DOmK7Dլø~\_Xgԣ9Agq㒅Kv{;X(` f/6hF LH1;~D vNۙ  e]_pIj8TJLZy z)~!O~qDW31~Gm*Uny$菧yWqRY-L7&'R4ybjS2N$n$q nHFJ:/dҔ2}4ZX0ĥmhC&kKf' 7p%u"PAfO@A2T.W9^y,p'f}ybs[U.wtn hYYً̑fv2*<ѿ%_FnOsFiCaZ E"^ZkP?&]liU-I9E:E^@m 8̴6uEJtVpgp?'y#ѧp )"&gw$(i 49(OPʓy6}eːs+0MکhNwnNwGVJBO{Z/BPg'tS$s/+r0B/FwvR^QӬr'g 6vz\q_|' {Po ʸ/<&+_2 kp$ġ”]{9FMEX"*U߂Oh~X1Wsl;Z|樧Z&M9 -IlMsSp;qؓxa(qkЌ^1y<¦pUy`;W=F.JNh,v!d8' oQ{ƕ;UX:| i ϗ۫~W^|uiyٯ`0aEǚHH]B6z۶Ar7Zg, t9y711X.euQ:H/* w=$4#ںGc,2{1"g%#`ދ !Ln"{tXBu>|]ʷ ŕ!-I}SIl]pZP1Ϥ9@w3Wgʼn<%3[[,ԄSz3ZsW'CcgR5-\`=zrw{5FSTPցI9P1tՐΪݐ.?3fja Z@$lLm:%ߝL-F9ds2\֠#qq+FE'saLB0j/umYZ~tM hm/Fh`]}=ˁyh"mlmi&q+5N`KZݸIҼf, m6u l8秂?aB]i]8|6w'r6%ߘwM4!KߴYPlrjt"1t<4Fb!S)..1BfruS۲F)v|J-9vdHF*NUBQ1zrѨӃȖCMn%KuGHu%2%DEL*JQɋ-鎥:|]<c;zO 3H2_HSKR`ȜGb[%̴vh J{6A/LYWTL(= lulrӽzwoOJ-vl;\PqveY.W~rk6 ]8i薥WD-:Ocֹ6sVk?{)=CM+uzANq7\/<Wc-SZC#rw@$csxǗ=S&;%S2Y2ĔfТoiIϪUbC|2RrWy(⩿ׄ\dC_pL]S tԐ3:JU>GyJ `dFmQ{4d+yPd0&EmwS+:dRy=c.1 '4FHT(~C?6hGbe-A]eo㺬`E>xx&d79cυUԋٰm te١!B&oRwxYB²9~+ghE }"F)B5 ]:rA"Zϝ֡{kP*z'֍|U6gQ|дLI>*Yw[7~ETq3^Zlu@Hǭ8zUHt-˫^ש3 K|yuR,$:-j$CI#>RJDR\@!ʌklGi 8Kl2iY%]e<2ßKɰ6^XKB~IY F8!r0pWtW]Ѕ( ;1 ]s^|Y $X<Y%i(χ:5Zcyҙ$uY 3'[/24EХJ75$L~9$+ ݔHWq/p e+';U%u(zKJ | =OxQ?Q:GѷJeɶ*6KK5.3zu k<#4KwH0 Ti51apgƮO)VOg(?JVj=`g;.shP&W<p=BU*U Un{0hLl4LV'?2>G?ά1BG'6 FaT ɾ;YW͌!Шie7u^,^ꛏ?ߑG%pZ{,]=)OEY5O<>{l\ksX^2J ){"@|#IUJ=9:-Lw )mV|Q8 0qf5uQ>$ccMcF׀++gm2MH!lA +Nv_6Ͽ%EMWT{hHg)ȣ[쳶}TD8{gpd9Ba7[O4w(zf beuZa*pŌKc&Ψ5h\^ *eͩB&Ұb /w,;rڀig !nTv$2 ⢆(KeJ G2jd5Ygn%GT9Eglӫ]P@Sut'2O&s='0lq_*<4]<и}2rd$LnzK ,Щ u+WpcXzwC!PS!`8M@  Q9-#C DJ oہJ}#4\@CIJ]_''6Sa(DM#?rJr_)xNp5-~ܹ 6''R-6s^M;"Eq "AVkzRUX S+,-\Jq!f p+rwO̦4␧`r3_t5^je_εs椂 KԵYy$MT5ϭ)ge(߬>'CCn`3Ʈn({}fKx<FjJQ+ʯ6|= BI{fEr-CCV%WB҂hXaK:r hR^Fx6j3%uH㎵>*򘰱&35hHCx(HYXTcSBm͜ rE҇)wjY!T>=_Xi.Gg,}s@`(ϧԟSiuT~B[!$7Pwbʄ@l(TXa zY6',.Y6'av>K senϝghhyBFer$%Ңm=ԕ>cR L8aۗm̆bOŪi8n:ZGjP]oz&b3^[LlG)Tλ=XDrH,3:YbKoId\cN4_Tkbk16P/(gs3TnKsQTj'W>k;ZJ>W#0-~KgCi1̈́j']],xo <N=c>kmB~uE;"4-rDCfXhD&VeDn0xQ6Vԗӳ괧XnF;&irIl CbV*;X.ihS6R-r%DKdߟbgғ^c1 $}B&@T%h ILw/os|ßOƝ4gSP6*8n@C ؿ׎.}|$Ɂv-xjJulAEu]^54TM 5T0:; )p>zA} UUq24Oɳ{W^xfy6D+)='4DKo8JL-=ËbŞkaHV,OUq$IK%Vn4Th `|:mEb 3q]:~L9sRAdrUZ,2 F_ˆtga7TlT޳5*7O"oL1e;;̮H*kCo,vy߿rſh,"gWJ 6u┘nziRѬ7Xv05(s+r)BOMlfGJv M;;sn IZw|T6)Ct3eq,* IS*~Fq~_o+~+~w~yzXq.W;Q7O'QX _A+*X8gI_:i2I>=T 7mݴ[lff8P8ZFMdt[ug##UIO 0MvMpU _$9DZmpFۚ" zp59y"kbe0mjhpMmqu#U ":[Ia-%'{L#wlu:~(DCdžI#OčtQ&=tpeRe)OCb\r%I_hFJm̬Gݿ-?Y%2uL 3Pbżle'y9SBx(XG)8#JŖUa]|*P+f*XpV Z Rp`mP<X^k?`b!VY5|YR8rz,[dXM9  o ,;ܨIR e&6HKY(6ŀN論Vk9 D%sV'ݽ=y&K%$=I=ކu3 ܜ擶$Aѥ[S#("4Y:UWcrrט<^=?#FQ@Z.Y3H{u}oa86U Ql4Tz&R@8FX/pPf%YW4)Ғg.!3pd.JɖH @9 Q# ϥN \amxtb3*aKr:@7ȜΡW_qyq6GW;YZ/iJ,ǏxRF@YHJ7jQ~9"ko7 =3?\P=5cL*`P8}l*ȶ M)CS_T苈!ca,$ &&La0D*%k,ONKWx/EMˍފz߷eaY7nڊFr\I ,&G_?OB¿7QSyfB OIRTr>qTSoT7Qepm>*^oA!tˇɥא%MuCq4Tڹ(K&1aV*S1P}bBYHp!'2g FQ4nM5Z7˜x)Q`%9Fc"(Nevf_&LzDsCmvZM !!xb&QĐKE`ǡp$SR< o~҆BR;CIiiDݘ,HfE"LF^F%w w:Ȫ>f#ެ]v!N:%(gO"[4T엶^R3ޓ0rJ`ؤN +:VTq]iyFj)~ !1OϲCes;wlWf˵~zxekte^MٽRy$ !dE6Gt`a3sfc 3u`GWT23HhO@7\/M &_Th]T8hDy r&8f<6PO|ˤnYUulTK2;Kԣ0$嚢R\m6 QU9՘"Z~eNu@o`Iӑ8c`dJ_DjrM&intaT9{,=OaDAZƜRr)Tװ%K5bI$3$'Ul֪;b-HoS{|AiY;I_` .MxJܖe\҄\JīD1Kչ7%&84W} K.})ɶ!LA}%qMZ%Ts'2WMEEE3PsNRGiQU,0H-᥄*R@Ќ} EA8Ѷ O.B;%Z ךߓ\%BH񆖦(3އ2Z/I${[ӣCrФwB |kRlUÙa @*e$g7E㉇HZ͐Ʈ[XR/^'i}(h6@ mV@=(3< N#RXtGgnR_KCscˁ}ϯƭ`ւK4u cgM6K_B95:X4a'w-$`b |v"Åzs<#GK@bEW >3F@-tJXKsGxeJP">T`<06͠-emgՐXtO 4ʔ\  4Ζ|;( x)auI&:i~è<=`_VLzoNH&P%,: [׈4РF3yk\z4$ʚxt 8j^4e?i<(oӽb`AiH4;c*/sG"]bš:-XMZ%u%j$\ L)*+"I&=HzCNs[YFlXk08U1 _Q-oWКg'n+S'BM#j e\۟貋>NJ"(}뜼aW3`+u)qRVdd)s̼#9Ыu1%xkžfQx+q b–s!^啧YX͎le[zC7ŝmN:)C;yXfjH!~b_" ͡p*gq$5QQGL:4=wK<ELg#MU.M574iFY9-~خ3N|׏;X/ 6DA\:X0)&z{a0yyt:;J%A~xbGDＧDK<%h&kH&Ϙ&B"uSg1Z߂.h"ӏxy$ p|i#7^zh>E⸽4"a}LJ!i'6ƉZ)vZ 8dy~AOd&;sg][WeV5GLO|/ǥ8;8!̸y"Grl$c+͖o|-lOlʆ.7[͖o|?Uw0l B_ۻRmyWk -}uv8N7)q~#Pp]y.;(]WXEDEݭ,Q9<.MjkQGu4Jd 0&V˚<$*xmfɮ@jǸ}y;/'~{[c㽮5ȺD+ǕA7Phr'SH*g,]s-l[0 qU9P_C;ώ-]?ڍU0֡BJ"4L9O |\ƴ2qhQk;l .hJ%} v#]zߴ ڔH/ G!wc/O8]g`4EPvWc-._z 1i7.q*QdټT*څI:`LLyDނs& kCf*˟D'doҖ9YUClEqSg(ʯo'A<ϯn[Ff)eYi^$$uYRv3t[^t˒횎UjֶjMƓ6,H(uqJJA9L-a-m=+֏bLWJ>pĝ1oXsx,GRxxV MƼ3V5yXfM[! `-{ʍ+u!!,>zP57<7]s}'_)@ j6FӐ{ﻙӗ3yfr#Q xe4+;MnCӽm}9;ƤP3/Wj{$j-_dL*u Tv[ 3R ыjgbV~ĸtjќ?3<7vW5<$b[L}`&'1dym7"I2XEHNc2lNG@g_LZP(HNƿٔѬ5d+ (^ecxp&P+R  V*LWt* 4 ;SX8M!c]2  N@Wz5:/fރ{P{jAmhy _PTz@Bvw&(_TDy\1OM UJ㊐]qCd;iMfh)#i)SI eRj1 5*Bk&٪:ιWA1|:ATS9«vs2jBU(嚙 Q[$-)@~ǚW%#ڽaFh[S$0I1EqXj[S#6U*,%ܣP *;nj嬸 Af %(,ekHOZO^N{)AGdvS+,cS }ç9*x4hRu{qL}֡T{tU"7E=8KEh@>=)ѩ:zk)ԨܶTO|硞kzNad1$LvL6PqT+ʷal9XCJy)Ck6A7FFeYQ=*ֳMtPXzV0XajR]Z݆b)TokX sKaz2o,^4r&?PB%T'kk;V)z@T> qZ\b_y7EtbPЃ|뒛8JbG[%F4d` a@:,lRܐFI-TOHSoz85NGyZT$_QEژopŸnY<אҾ TZG5[[F * Bof!6G("<,6FX )3K/ \dWyЁivڪWi+ n=^Sxl}0뛃nbVm7ب$%w!j$+z&PZS@L`#9]l2VE0߀"9jh>aHubMwVvsU5ϵR$4O]eL+ Kq0< vy[ڥ\}i9`8x%im2G뤘-鈀R`њ6c" bhZ',A IA܅9M\0ɘ_H0)|E'_JߤN#yZA׈LUG=I'F5B~TAGlꬑJNR+,?wdJDSd6A *I( Faw;"D7&$omZ*piEK˳H  ~ZhTq 3Wu4@kz溏e-mY 95??]U=ݺP|If6Ps2E"o5T}1Hiy\I7O"EeVU&'Hg`y@`[ : ;I|ږ=A(E!PVpHm& >PKc0n[v ";U )HZ8tIgޔ_\.qEK玘kj^vl0k;j1IX]cf>%X\pCvWv4θrD'˰G NUc,PD]\a#:p RR7ȑ(ra%³ɕe-le/[~?ٲsE˖_-llkbux"U8G_:\zHil՚&qYLp:cdo4Y}ϳVۙ~%_i\֮+1o.d ,>]k[ǧ֗>O/f1|k,1e08 Cwϝt.g(ՁSg)8גSɏ[Sֈ3f?gxjcuiq\0v3魰<p'2`q l-ĬҮbȊ?=9gJ{5^l}lx݃sݹ]n gXӪڱ%DDͼ״k5i '$6*q٨"W[v K9rbz2\'r c'Gf8Lx§Suqs]DРB-ra/N%mRIxUVԔC7- dLE6Mj\i+;g}N3/ƫhրBc`*؝N=5&ݨ#%:,Ԩ^g8zz eRpMhl8l/#И-X& @1}05*6㙇>֚ &!FXb5ys,fFb|9qa(3C#Ւ/~4CtJNyf$ǂc)2_ҟGi^nP&Z]JEAAJ=2ҤEX5ϊk)!-d#賹s`- c`,HNrnp?)0zA8!OPg,5rnp9IeYl RtL<ҩh{L=CY'?U k#tuB QdR ˀe޸fʣ;JQ+TIFp21^$iK9?=(ENm9F7rw )hTxQ]-vg0lNQ|G7pD%hj?ʄm!M7&G _ #3vܵə9΢$:cRHI.&?UhF}]t]qiyS;IHXR>f dՏK uewTK#JVBi3iܦO!k7Y{kazcѮǍШ`$*F8uƤHfZ4X P\4 92nAc݂UjгI?}/e$+ )埏"5bHJeLKG?W+ނ7&k+A3b8u"*Ko&W)GHb`qqCȕS`WBMFE]Fn9. o bB$dGHՊF(KޅɆ'hX9oǞ>fKHN+Ȃ|h9JՆKFאbQ54w{T31Mv@95Ap%T%9i[}C>ƈ~me7gDJwfh7;96nčq:~jzG &j4{UGT :wWׯvb'+K+N.Vc! SFEh0,&&.VlsfH\U+cKBhG^5*[\?m k%@]hk\GpX}mduCqAc`|(<2]O>UX ~Nb'>g~XASȒ=W+K}c7^Pz׭/GM%Aĩ|qO!hgPԺuf9ŧѩԩf\孇*TdLazNO*=_-cNkcf~ZƘL6&fJ0Qh *=DMMx -w;=Rĺ%ld/[r_)Ņ8QPuQWF:yQu#u׃CJR%UPXQp-Yt7(kfldz?°i Ud=L6A<|aΰ|jL 1_*Y;%ed?$9Wwar#W(6 I.N9l1c߹ :<6dU 9&Ub[wĭ=J!ኘS+#o@($`$xH7Xvl &"*>r[Usҳ8s @! OuG<ۧ˰x Ȁe%%:<㑼P doz@2t14o2M BNdMN8r 3nDҐ}4dM=1bl3~L=j! $VC]/ eDɽ`X"~Tǐ_ԗ<__G>2I{" A|]6֡b~jg,irղ4QDCz4_[jYl-۽gyug!6ZU}]{oy`&Mu_m 7N"d3<-)QF UV5 8uT?ieNjJT⁤r>g71@ i1MbwicXDYW (z_bR g+{LWdY=y&EVNtk 8!{OI=+D|7K9H2' ?߇Ck'jH>@M9YiNGO7E}=K «KZ^[EuоVJӌ/p"**Je:A[ :;󓜵#(5ȎV$Bt?[GV--L41aMJXl*H,6vN,{u(?s(RW4| J.4bs7`OּHEE acZrlKqW'lzJ% kR4aιz\wy9`p8\hE;8NqRO>FMߦH@Y_t)OǕ<3kfS':7r$d~%_La[~Ö'k[~Ö?ءځ}xf]pdzZ-|vʳ)8Y5,ֲָ! ?gܡ 3] qݦZlvX_9e15sch+h1-s9ol[99Z 6M`^5Xsrkiҹ,F0l_|uW++MKa]rutDYDZoO`2dp xmbɎ@iǸ|y9'~aC݉ e㽮53y0({ XhW8 "Tf;_=19g^_aBD A%uS<+.,ucsPiŇ3M\K<|@1y߀SIk )@ xʍ8yWt4K} v![ScU]:o ) }ܙ&ylnװ-@vz{s'$G֑-Pi w1 -*_`֍bR o`UqXV̲x?6owbO`-N ]3ty${|8d8˧g-{ ߐ+lEĹY40>j\tF NoM֓gs]C5f"ŧeITo,H хaDT%;d[C*M"AAJƶ*M_ZH{~k8q)H} Ҍ}0'Λ6L#IU9Hv9H'J "VwDB_HTG )= |Hsla62cXF;k"ϏkҴ"X m֔/t$\V5C,X.cn@ in98M1F}%_%@JҪD`i=ΚE4Z˱gzB~Gr9=$sD`A"7wCJU^P] -SvNX NbFZRuqLa!N HrtnY|hch>*B/ې fDZtfxh{kG7ݑ^җڛ%7J݃û#0 =bjV,ЂJS- p; ƾ^ro,Ogcm?iB xcϓ-x&8M I>X rdry-J>Zr5?7Dی+j]||3wEhOFIAcfrk<܍xiRt'KDD7Th}-I0BIGUty!բ(SaH![# YFmVi5|@)ѐ:ǸK0=sMˤ7!6ة}IA\y7ly|3u#D3탰2j36jq\ZJ59r>TjK;P69[Z*Ŋz>Mj>nr4 v<10^lG=[^zfK6yR7ez5x LkgMs/m6~P^'P>y@!ɛJ甐FNx@5;G5Y6҈+]DފMuPWZ 'lܒhfX(o56X~74 3=Qi-=V]Kl ֩5ڛ9i(D|x0 ߦ$ZD#6HE(vGr|hCnSO՘/00VY@gۙ #\e!& &СTc=phM2ۛ TgW%EqRSK""qzVh^jϏQ 9?d\4`b\ԔHvM;e w:M.0~؏&B羮i#xc*/Gf]SÉL*L20c܎95x# ^aK.#` Mto,Z;T{daCԠL '[jݩD/'ϘN ot׍ɯo4/5&MݮwkwNBՐ<77b7@B=ggVXblYr/||̫}.I$wZi9|cAiUM4iJ-]/zWo0gQL#(uVJ2(/)*BR ۇ,#gqeh|Pf(8\Dy("> u{vvpվY&M]JmT$$wʮ0:%R^bV `P+=}CsɚoN`xVvZALa\<\!iPq¡B}nZT ̮^ aKOS2 D'uQR=:B4mg5\rfWnѺ>~~P )+/HjGѸɁmka@ !M^`]V&h h >1\vhh'%kv5շ|g[st%s20 XH3DL̲i wukīl=W@:yDnlSzD5$0h(bAh /ˉn8'+v#(|Ca $cfV#J4J#*VscXGqJV+~EZ}׳-UJVUkN *2zI"LeR[a݄FNH.l(&ir 3A9 eVԟF5N-(}8=Q(эW p eXV?kC.5fd%K#t2~ m :49dO͘,-UO*ϺmVTtr[TuR!=bXݣZn+cdX{P=)@b.<$x>:[e_TMτGYi'ֳC|?aְf(hbl_XtOaOK _a+ 0 Ò$ Š`Ā_p!ʬϾoSbgW3NwNԏAo\H-if χ~zO?Mpl|Ǻׁrp;;aO2c:$n!}4j6E ?Æ3l7}^Z ҍMVKm˨a]\j0'+-HJs+|rQ9]_xCP.Е!(5<8^E!?KXk_UeП)mJ*wS +ÖHbԨ4zi7=l|ʈjZRjɛxy%h?~)7ס}6~"8~%׹g&O6~y 4(ꋅ૕!fCӳc9N&U"# VŏT\`w+EPWaw{xB/ղ! Qi{p mOm<:ۨ3AIb۝4GC)3|ďpwRf- D۴y>=rsxd}kZvpN$ Jsmp[z @o~2ݭq$`5]Bcx#ȊLcc/ؑ:BV>S3zAn{ꁨDl]- Zg;Z8oI*C.1V_XDXy'&U#)-!TQ˃Vh򵄭k0¼y5%,GBdVpYIrYaA͎|qU ;{85n+FT;N390oߞJwryz Ve"02F$&8:iuf:oYiJ2hN[H};2Dk2v&;X2i2I| e%%"--Gɭl)eӌrrs˜>J!fKG,2[[([Z?ɒԤ{qwbax6)TLGR^2HêA.aCf}V3'LO./MU}3ɇW*itI}%(-JౖuӢobq,7KV&v?3hR}w AM .N <46)&{D cd7S*C*NUl[ѶG3-7Md+-[P`4Lm^rDܓIOs%`zg|49(=v5ӄ&d-Z2<[Lλ5-^CC~ڽWCqvnarjoc8|Mpz|I$Vۿ1nփ_ ԃRhv;hhfv`Fxi{0e(Pt܊r<$ua)1rtdIؠ0eѶ)єD^Q;&[ܽmeb*wyOB)aZ43u6QmzpUxoXanZڴZ#"͢%2k=O1c,AO4ð Qy/L|göfz~ӂ +eӬ*g8xvQ7 ^s+N{4֟Ǣg(P5cd-V07uhn^ʪH ,oTO/B{jx|8/'徧!Qi9:#6V W;zM?ynbܒPi5 >U' ::밡]cAd'ImWePXEDj hL}2`.љ_T~DZIԳGLwd0{۝R׸Lb=p!NMxA_rxYc՛fVG"zT]ui5X{zPNOn4#2ɉ "|~0!Sb0=b2 E`YL}A(?;S Ў+u=s6+݈Բ4bf.3~hx)ZUG~0 ]*^..W]bM#&OANJ/w*c9u40~7АtQ$2o؁%ћ "x 36張ڷmbuArJ&YBK'j2CH̥1HڊSj;K6Nǒ}7q*IMջY2F#kddGúlE+^%9sdo&of;5Z$c/CJnʹkmvjO k0 pM_"hȧBDȒ@3;r%ЩRiqխ:sf묢FU [^*(Wj7f(,/ԑ=IIyBAdݞ+)[cP 8vK8 \?Izi`'`:lVLԵwm}j;%DZ\tmMTyt >TTo`kO-#u.HfpHV ؖnA*ϕq7MFڧ8\ő}'F=dQj<&ۏٸ3V;yA.O߻N(iP+Pf>@SY/D6Gk̟;NkaDž'CD.7P,&ah8g)V6*ոOhA ++U&P 2M6a.h[Yu,%ۀՑA Ka=0N71dP)IVϤ0AS븠zYR]!J'Xsy#T)" *JT'RRWL킜.:.</N!O.ܽuAT=6r^"qsm7< y:x;n5!$+Ax <k7Ekivg,rsu}7w[* )z79ϳp2#˾iFm[ 17eXEMS25~БydAcR,*QoKg` ( aN~ m%ĀY@rs+E@-K޾3UxQ}|9{ 1*X琥<y!SP =^j T>30k]w 1\愴dS3sC`5S;N;7NrBIL:5>O\xL:Dz zDHgξE-m[meD+٢*p`p}iԈ`R#tŏJ(-fVU߸0tΛbn15>th7ȏj}5BfwMk=AA|BM8[c3#ehCa H[`:oQ4)/YW]i/Io(@Ppq@Rɻ \Cin5-)>?/_bѢ3 ^DEKRqPkH; É°[KJJg@DyXVA]ʩ{d5GIoxx|8NNˊO {j&q\ʼ>lᎍ[z 7IL~2pcǫ4䘑/랕[OzY(> u HD1rM,e=͗pHb񽉆&u9jh9Z'5(<Mw č%R@,aTrU&IsmĿ;tUM$x.WeVSo  H5]pJLVu!y[#C2YSuHIj/Q08fWYLʄzX_Wi1E™HY3ѤsGqJvԩ#9oX%ѓ,Ww2⥉n{])V<>N|'̦HiU#@v>\BvL(.Y]~2$&diT}`i㐸jԩ6r]J2y}-șHHIu0$kdDxoԀNlOS03٘"_6D0+] ".Fx$E(aj&]WdXM%Ӱ-HuIL|eӠM] ֟Dk. Z/\B:_</݋9_) :Mycuqm 5LM&ujl Ȭ^ K>ć͒*%680Vd35Itm5 (HMBQ  Œ[}g걥$(U;]޴JHqi:ՒMvӬʸC}u}Z{s:g0|i-N+H$,p8va;kh>Gk `qJ~(Ѥl64[Ye(-JؚyVߚ٫ G'E'=V˼/ey!~˘vŹ F7Q Z5+}k 8bطMHЫԃTx?ӶnWʉp%CSLUdq+sErkTeӚS;: O;VR#Od!?Y4#Û&>3v#*M%ocV+ĮJdI|%h{>8r 0/T¸r[O)@mS x)#XSyq0<{UVug/qj6"`:w-eF˲DI],p( LQoiHLgO/RalI]\\s*vBU>LD]qĮ J%ᑋ^ TԈ`;_o%TR%eS/NRWL킜.:.<:3O٥$ZiAoSX@'k;eCr}_5,q?nWx๾sϴ :V!n=P!3󎫊QB^ޠ_D4Ɨr/],k'];?EP1/&VAcl4 $hZv%xrvJ0@٩)a\#uo TV /TeJ$b HJbbUĿ&>@ǣxQ~<أ(MUڐSnl x6_(رݫgGJYktx-He\3~&DH?=hg}~ SL$![j+q-roC^Uħ[xkwz˜ZjCϳk}F]ǻ wtRq(X%u ݸkZ]//˟:^Jz؛C%q<{ ;'ca3_<"V&Y35ƀCj9؁qL~`FeќugtMS>[tƼ&L5uzaw ʍ S7sbTO05:vOq]`2 ,OaSB@M@7<ۙ7vҰZz%AUZ+ 63__s8'鈚7A! =6o=ȇ4jܜ߈Ehn7u[j[|u3._~XE7@r(BS[~-&  N\SxSz,kPyPգ Txc/() 9:of\@w$MtIHoa3P FN0`,S$tjz(:`Ґi/-*7}}}XF>un* L (˔OGP,7c$# 2?)k8jZ%*'u#̻4\Ti*VP)6^Z1w+`h ogd(jO0୷Gdb*QPUy0΃f:|BXƳ?9M!!wbo|Trt`r&F۰Œj$@X4̜I4,l!{QC"n+$~pm241XYS;8BHO "D(V~ >!p͜e*Nf]ޗgˡbUr xt`nC_x*ɒN,/tc0=UVrɨkZMs [j\w HaPa>`21kЭѴ:F%~gO[:7h9FG,`U6` WGixuA2^_Ms) ^~qdԙ j$Z,C7ovi%F]wH2L(/Ym h|5@gV~S"])Ph &O \Z8~n C m*lM巖?eN%G$Sq(B.][y>)_Vo,v-:}5tmYӥL (3jͧH.7ltdnˁ ]GZpN}x^7Q{ 断~_pɐ`Li7C~ZӢ@ѸӖnخv)K}$cxx\Kl̋xW8 C &]2hh֯e%\IWMiҧLo{Ir?{]u2Tg-5_PpYG/C>Kb7*s-*hDuqQ[B< U/N|QI~G| سD5ʚ) @H#|uw:/ q5_d>FzjN>vЭag!b*VV]C彽=5AvJ},Sw{GB' Gear7-ǁ?Q(G|3%O`%BMxT`ߠ :L/{^|+{JuTQOofƔPGk?9bC8K6ND[ߥ| 4%@iv_W~WD-B[Bb TG3w#nh"7 Y^;?{hyV}?<8 ߊPPɔ]:):)dk_ϑ !E*#s*=t0J6( //[)]WhrW]ގ6$Ws2.: iyYsdu uCt. lty@uϩQ7fe\7cd>p sF-WOmjpH, m&I1N7+:u,Q!KiSTOeKzyDphCf eJUURs̮9O5Fh9B~HbD}$JMWtF zl oPhJ r|sɍ)e׵U".Vb!~Hd/@9  QhKF`z(Ea"ᘌ;!7B#N5nJe:m39B)!%ltjxqD*-a`SeĪ%a%"ܠE6BmPlNn*l?tڠ[}G@,D@: $zG٠6T #R36~WiXVſ5324|iWh➿-E81W `FVi1[ڶ|e;VUEW~LF\?F"Ny3O*sDlhVDLz*:C0@5WG:Ekf014%oW}c'Ȼ\dH HQrZblZ㌵5NNE]vE[Dꡊ;Diơ9^QTPM'̔ۘj4 )T<ӂr;H5~>Lya:hwMk`1Pq+5[K72 {HNW1BZBx9(4Pe %Ci⼆EeZ`"FNH/w0v-'Sg3^ & d:'2Ȗf1yK)DZdnHUE26}nN_K!Yc50KKlrH$D?tE߀Fj=|S:}L_Ϻl4& T=˄^ߛekVo&FrU@nR$(9|ל e d5\WǞAl Y3'trN875CtjM4<eKaز<5nQ} ހMhkWy%mf-ZK/'`mHT]}*1[.q1$m* ZqPUQJ&EC'T6_ rDTu`ǿyx4@kȕBm kB? dxQ̲V!Dm0 hbEj/U[K!?xpR,%?y]D8j^CEB,sߚtE>l_r6.}m=\n]R.{9mR#mLr\9#I; K _<^tF1ה 6 cRPU{t<_FsHyp%OM|+W?5@65 2L`zks8r`TTfU05;n204ftkj&ˊQn[?%*;@H|sgNzGfgў@2 y25 WuU:U"ymQPBLu8/zʬ ^Y`:GUVb(&g~ tEM\TDcUrg]K]'NCi/6~lX ps}i& YFv+u3Kˢ68^r,]Q4U@xA`yA>QeI,AST]f3DDHѻd|T Ehr6@kpvD\O7>&F,dYN$W2Wc"[pcXb-Hy Ua$$C`Fjq3 FjMϚ?{'Uȭn#oS)vc)O;O6aƆc'6i-;ԩc05BIoޥd&a )GDv/y"u6#AJoA%EX= ?ʧa.aٻ\#56n4v;$R-~?{)2:f˂V>b?ˆbvNs7m~z\鴵CutZ=?tD?AUd4k 9PFoXspkR;m~&^Y*]{zH͡ "98=;CIK<]#ݮqW5qmG` ^KWfUKY+ٺ(oY^ڒ#߸spqTHߡ{ىV2U*AF$;O8Cp'liwl(0/G( \W֒YprqhkJCBWE6x\B4FDu>A* ?U2ױ?gN~{V+Iqib3!ۏjthbܧXwG2!pKטM쩘4E  j}~T?(rMI< g q9X*;*&Ɣus8-cm\*dGG5l 0$G}JMΦ'\%8ZL+RsuR2t`l,VW^ofч(;U[͵J&{\P -Y0ח&CLAI_V[&k1z0EU-F ht,n _g* QUQOQ#\  \_icT:ߕ X\Z/ymJ=BY9]Tya7U3<rՔJUeiQ!S39PmW1| pCzRIzirzp;8|}7 h?pT(kd~#L\ Caͮ\ѵ}cѸ~.~z!R30HHHӈS#v j/DBRVxL ;WyQMC?m[SӍIFX5ejA}1_Q* uAhz\Xn!u%TܣkC6ךMmJsmr%548[=ąړ/H6)KVxF!E݁q8qZΗ\;q5M 'ұC74clXCʾ Ԟh158g\_ )]WؚʴFu7'Z6=&ۣ!+.c~W"G>al+8H17Ô}jrhpt Qnt:$МӮۈtyru l3Xiě1bh?L)o ʎCe.S;!OC 1հtA}fݓ6U@H[JJnry5*<7y{.\xc!*6oТY۪igki]|?]B; N $]l-ҕt`c#j-~&BJDCN2 `Zċ5YcHbK1pwp#+/%bޣx,޸.T,G;geDlܝ`3>у a \_:wwVlIr K:/Xz2wW**lzR3ƛ(bArrO>k8W5K!SBro.eErI`Fr\ra&ul%.]O?0)WXyuJĢg}=8w@~om<;4̟?$IE*3ˌlųrR# z~H׿)7c<<9;Rx}dN~t-.w@$%u/gtB{U-dzJ]E%I/^;dOǎzPO*5QI"2E Ǯ15˼~~Y#=ᴲ%*J {$*;EGY\<ˮ݃{yÓ7oGNԪ E!r!N٩WLpd>D(lEi]49Ȩ\'L_t#L)~^OC5 ~ MeOW bS~Z =+;05)5@5N9ƶDz+f^kґħؘoޘTW\b\ 2hh&WNc44ݿ9y'u|9jޞ88?9`zwE8BN_!q,4q4M ld|ݬY܄Ǔke\E*GqyQנ鵧JrOQh} ^2=sGO)X}-Ѧ-e{}u}Гyul?dLzS?XIzhpQ]'i1 T3@%ͺtR):lF͠-~ɭ폕^s}|ѧ?-@qi#;G]גG6 265LzP nUnHV(r@hg u̵r#g1*^[oF$S' *_Ay.3h5m mݳʳ^7QPV*I4p1퀩)2 ,}eĵVlw|[>},#:Qopj*&#kv8rKE˴pgCA,8wlQj0O두3T|&m Wi|3hOUޝ=4=>CG+4ߖcԧ{kPBï睖86ԪyW0V+{3V¢yC~:A~9oF->b[#!beOgƜ014JE$1z&0W#nq^N}x@F>25#rW+vWtϨ]UmWD/5bfjyV3ǀ&cJ9H/ߝgb3.! *} 3!ZxZ%QIj|~=cn,Z HεBe8qK>.-eS3gWa|H蹅8.{4M2쿯m@KCHI.PHz]g`4F vyYQ(|Pg7ᘈRsV~+YǚT*ܨ<+B& ̖I ]%F Hhd cZ]L.˟r/%& A+>ωyĹa(,6Yp crz+/A<ߥ7ĨȌ2kc)9A )g7g]YWtοAPƑDz4kDxLR/Jѧ4ϖɾE1lm q(un Z, Ȏi0F_#*!s~;,FwY$QIp3<] NQhaʺv15+RYM AYFi^k[cᖸnu3$dc"I*6͙U>h+HMv(Bql .^` 1*teÒjmw 4LR!fķ%UDRbsFgGR.Iå:+@v 3,88md܈ 8Dy&heݢZ޽[ԺClòh2~D UvkBs-њF.g4'h_ HH~hj-AWGe3 ؄<~db^LNw )mDf^bcD\\"d2hhj~=Ta洚3QLm9b8'|= K֤}CV"$t0"!.W.f %͂&Trɵ2. t"a]A}Q78GeQYT?UYlG=d Y]#bkTe3ůr  (uCz(4k<\-2Zk#,_U|6]r$ac/n!Rkzf~_QİkҦJ#OghRKA{z  |tFj#'߳fLŴfhKϲeK-:X+1dm)gNU%0Q-f?Wu+;?7o`[oj9uV$5G׫mln:"3yFYE\#6.kQP iÓB{~3sIĒ4f=4pKg V8RzQ}EboɊ%Ȓ.e!Kr/&ZGN(|\c'l:jwsY!xRҽ:'z6h Lk2wbX]fߏP _^@}jPB&ҭcmO(m_P5: *I]JqLThƱ!CQ[On!ﭑ烼QQ)$W0HfWh =Kۚ1;-CXy#! k)mR?W̲:;˥㨐vǢ9>&nڟz+QfTCТu(А 5TȆ(&Op<(y3\R~CԊ"ChkJÇ:2ajlY5DZٵQ$'1YɅ>#90os?œ*`egq6^7ء WV|]]0EV1`IrS%9~CKC*Wz -Z& (P%TWvv㽎jd0JJ5^zNWU}OvLҾ4,GZ/eb^󴚶ޖ2fs<|5?dWC&\K G.J_tN3%C7l;gIk'uyӖKMH3b(7)5&5io¿ˀ1fFx>7ڡ#MvmWS̼S4*W6Y+  _iv[%jӕrS{US5PO}y#}h/Pf  V8թYפ 3+֠.5kc[0\MkC:9} `wh=+T[juAQA= LP_4--Wxb9nm2^!?G6rryi({p@m٦,SRi3ek*]&5g̚Z`Jjz[\Ux8@GV3nx8K%ߨEs 84~:%s$LR} yR yqu%*.Rqol'Vqb;Nڧ r"%_=HSHG& Y#ZotA{ߣ#;;6Ҧr8Q31])hKX+β7f$ޛSSb@gsB(xLp,40=Ql֣d0jUw yȻݕcKKg1L+vFz&)R|l 1Us&aWks-S)]S) a%%"?oQt=1cK3qY5/AgE>TNh9xeͲkmـAlG\S& bzUi51P9%EV 5FjۧbUp(=lZ*6tqGg%+IWA|uK3b2SsWH r'o>x*o Іo~E+jz3(3( l#+G'o>nR'3gZ$QPfѨDP$mqWw|ّu͉rQo,*COl-P^޶ $C ;OSc2L1G&)ˣKgJޑڃ4Eʛ6m6ˋg,wo78'~G>~G>~^>N[u}{U_8+{ ?e %w6E%.3iHWJ;gUm˪ywm!tӲ',1يWO#bˍIY0&'Q]lB8&m9(k7=\Yz] uI6W0p+~{}הXHĦa eCݗ4{j~͕$ i'M`P0Wi9ViMAX: ~gв3g1]p,*}|8r¼Rd]WH42+M+HLC[ܫ7E9rDx^!$p88ҳRbDiuC; Dx=iC DunJHPϸZib:8viL({,MA Y][8=?&V R<^nR ؾ9"#XrK}pC,P~8Th\exZ5akvKB |)2y-ڎ{0 n+ؗxH|c[%BQ,KB'=h'$ !qюWs +%/U:D",~1%߱k75dUc+$eMR0GːGYd:I"ײ= #_z;9־3VDzt| .?ݖ4ɞ3E%;$ E}b6:G1zqYڕNb p?#fl-":Zu(StLq9a_)m:Ϭ7 [ZK?h?;q-PJ $+p ݀p_66=W[-/][XqYNMNb;5 }<(cN~O)Y>S3Ss3P恁y=w~s]bs,RP_ @ﻕT+nQ5l @ӧP&U1]P&WJyz(3o@Jw`B_څo?BP3Dv(KM Dn܍~!P*9vlSt rW6u=ǛOEt .NE /)h>1VE/w6Ͽ+ "ڹөT,$I.-C *Q( {ԖƯB"ȹZY=0qB]l1Y(ņ 3k*ّjE?mM/X (7)>VE){ ui3ܥS3MNXyF2j\RM)ák7 [SF[ W}BX.uF,GY\ѐ I5}A)hbW { Sp2$4ޓ# n] ?,# ,zdؠRяM#lϼoQes3~ sr1B?=4hcōڙJ3*\’se}/]Kl DRQ-Ȁ=OP[᡻ĺJ'"7G. !;nxQgZ'ݱncDkB  wuץFc吷m{Dš7pQP/JC CvxsY]<RIJv{إ)J6mݬګY _q)\z:@+O 󂖗oZxe|ޏbQ9zmJ/`?ng~dIur9!Sfȯ˒i]:\ŀ|XuN@݀ψ`jHRjIr_iZRjMx.>}g|_ ݛyh':[HwOzv৙,ckgj;ׯٜtv>_u҈=Qjҗvn52TѰr L3M1ė%k)5,$&1D*!|] Mb*$h*$LMsQKЮV5SjN tF< 鰌@BE*.?'&8PJR(cI](jdK*cQ/)% p`H'rjC`xDѮ:-CY&0h$tA씖蕴ڍez[U.%PFkx h J=.mPIshXҲ?F",*KǼVnəVcRzÖapGG}Vhg04Ogy64\ܹ.c˷F77HُHُHAUcwOVF+ᡒф'5$aHۄ(vO!m/..^ @V)a֮O'lh*$MA.姵2O+R>cex6{@{7q" g걞{K2n$0óڛ}ÛגkKu=; 2l(?!%E#:  piLFIj _Z `61>8!i< Nj] ܙdzw UlB%n-h< -5Pxr/_LN2ӌ+)D5W*z̕ "4&S1SD>3vZޖ+Q49C1H]T#٦~Ƅp5Nt% e)_4 MUi}|錆DRbM^0:WJQ%1SY9Op^N^=X҃A!bg >Zj?tWǚc3o*1 aC k9Ȃ1u JRep@;a!o{-ЋC@OUvAYys=ڎgb6s|ξa܊2Lľ9dyJ{Ǘ'sE8rmNqޑc:צz$MB<,$vH Ososndb/ͤ,{em4J^~I}kLp.Z/=}򅑷>C VoZ_OZ6$nǴe#QP /5&ًۧ/Fx}+-.u.Y9EWˮ^7)X;wHrRYk|C'E~GaS 'i(&J.-eD8ޕ Q]X]*Uˠ*yWQ2*ۮxxMB\Q"u+ tc]9F.u@S/u0 z|)6NMRK o7]m<uنe .gffN4AQsZa6]{gx qr T"4MA7Q*1F\nX/ HzzoS;Mu]ї urSf,Ѷ]l23󨵯S;Q^-j|eebL&9=1yo쯋iEPPaXB8~+"]& e6C|szxGt!(zξa 3`4Θ`kz8r!eqf#Tsx6?SwS@4*T.p.#Ȋ^ &Kr筞FZhQdd>8_cB]/34eԧ7/>'OD/[%T¨N G# J^.2t1j*I}BRx1 c2QUĥjGU$3:=ۥ*C$}=!Qpb-MqyG4(gSC+#d(}EOJ;H.&ϑŮv*MI@ lQ" jU(ALYXu@vb\&wT;Zȩ 8~5GA}C#dS{ R1rggB~,c h?tWt;ó{9K)em^׭0D:pdEi5" fttgsSM?%Iv)!RJy۹z*cv/bɒʲLQ zq!\frR{ etԸ3԰\ ADlce`<)T4k=opP$ 2KڐPM5ɭ5,"~MG71rUEzgc?11n pV{;Kb~ F $~9voii}r ?*Llj$bCP9dprto}%^>=k7 l|+ .YO5 I4 c#sV%N0*}L.9KQ`6xiJm9H^sn^D˚/x],[' 2ośbr]*B2Y]$ڵ- Zմ,{-~;; AC!\u5N:, 2tF@6S~ik/,> B()F9u)YE i1JjO)%{KeǷSCٕ^/S rYvIIAOc2k%E\$29>γ@RWuW^-L0y Q]&9SVNHn#*\O"7dm.#Gȉ`ҥƉx\`ߋ&c?6y+q'sat'ˆ20&w %G5Ȧ]]PAxf!˭ ÕfRu'zd>O$j>7LmUAƮu.X_;O_uO_uO_guc@;iwF\rWcu:Ү4#I RNR DɌ[zDJz\mbM!p2hN]ƆaK?G%]N)xҸ 9iq!b2d) " s2VT "jW5Kv`^}!Ǩ?l ]ތ$7D޹ X K]ݳOCƀlɽ^I$cΘ}jO4)\) 땆K_ǺɊM-oKi[,P#RCvԅ>\rh~vetOqo 691uthvDea*&(6o ! )KnL4lԹU<2tB%1/~Ө5K; mio{ĸ^77&CFW͕v[QMTRi 먑ewmr"F*XH@Yqf+lN"L:],"R4A/K^kW-WE7sT@W)(PUUᐻgS&?gy ǿ&WD~PG!5:k4mYS>!IDyfBQ1{z*roF3HcLt6N[ZLSV+kVI*TJ?=#sN50Y&Kb2؂ ô}b*1x/eMˍ@t,ܧ̸#G*!u>vG)ɡIIӺ k}vz# 8r ިcV@Qin._@~NOR'(r{H!هd!ٹC+{6o Fd\\d4R=̓{~F:yl {OO]$@{o3ԟ|⤌kN:Wv $#1$ Z🽨ﶢЬ*zc ^V5N@s+Gr0(4^ڈWRBN6^"tkRdd !j OP"?v\^9`GK({?4|R^p2.ء*; e nFc2*u 4+X||lH~Rx uIUۏ3+UkTJlD# 'gAfs83xCgV-g綮ghW"xu/6@)!OUy!=:=؆sM, I8Xk,DMԚI8% ]9)ߤ!IO)pש{V_pb:$3e *OUse,1QBG(eFbC*_%^7PC<?y\FFN="BKpla]*견 YQp&zPx|{*]j;ڍ6Dv]V"\Ҡ7úJH}]pRW%RWGc*(T9ӮRij6bd'][nzS킜qn>'NOa1duw ; TCAZ:rjmG(+y 䒩FiU;zWM✟LN9= \g+Ԕ:ʹ5h 1_{o01QFRǺթ}-99j&FYMiR_KԽ-hmgC,j CirwwΨ2y.'SgyI7#B)֩3Fyw^Oñ3*"0XTyOL2( a쨍w/mcԧa̵ԂWzY2la+o;<\T^+=1 +.3cS6&UXJC u-|KY^xz#Zɭ*q,Q`(bnE٪z5H?Wv)-[Va-CXI[< # ExDSc-qY'r#9gD"X$a> " );D̉yhȤ |j/?L6Hk) )b% BUV}α#!$R62F9<Ȧ/6Mm*X:˪4ŧb`"ܲWU\S;7y>fˤdhyPYiESI1lXsn:_c78jxU0W[&Z ј ~_ڮktH~\QB]T$cZω`rfOpi |] ܏Wm?%,a(A 8=P6T k".~] e575[LD9I{?v5%>‰0 vI63#]i?ZY/<_OxMRhecևkU2ɅɳڞC$ڔ{!ǸZC]$ py"d}ʩc4q9ȦS$ D*N~4=F'Ac\Ipݓ>M4ӐjK7u9,-\Ӥ7>^AW`a*f;X Ȱ)bSD$5N(] fHPLz %4wnjShۃCNA"E&orclr )$S2f\m$^Ϭ0UV:cR,m?!J[#Ri.l"uaP+gǙ]iR\"OiDDҲ| lˌl Yٞ%@oC %wdZcيCs[\r >E' CN냦]#ZA* zVc+b] ;fBq3q v)?T Bb_$t@E۹l`vѨ0tlIUFװ. aJ7Q]?@ >rHpI3zb*A]YKΐ3M*6N%NUg?HD@b:*͞R?~Gn߽i1c 1Fh4JW_ɑlԳL$WQ%ijKYK,bAgUQm2p7aoP"@t+!\٫ ]ʼjъl~Ja6t |&j/e"2z(=/~ﲤW,훥^߃U FYܷu. H!r6.LKyԷ>'z5RUo4n)r/):|wY1 Ac\#$tkI4ñ]X6U4q⠽wAԲCtQU G:f^5?WF6b'tv Тӷpa+&3I}ඎZdD#oZ: E tIk{ 32[L/Q8 /ᄔYEkͫܚs%=j! Gɇvzn@ڿ4RytUUdI nKE!/YCM=J]Rn=Y"7Ǯ]Q:"\Ҡj#!tƅK[Hո0' b L9BsTvs1`NyMrU[tZ9]Ixxo[wݗDD$躄Er2l,hCf[T(9f.؇RCIY$ω?j-?P;DMTh4\rUE>QAgMY)B_m)"_=tX ZcoWiO\S36E]~Eˌթ( fl:7@; A8*QKWmbe]MI#/}@W_cn~ юTb"ZSu-XizB9Y&-6Ok ]Rj.wT/S>#FS?W+cA`H#j)N}网 [n5UÖI$JfaW.۷Uޭ{Qoŷ%* -._3$tb06qG>zSD2bA2# o/9ÏI-+3G]w%ۜ]J5 }#; ʙn!<ҁvm]#k-KrU9#3}ďF醚d7dȸ-k^GG>J= ֣qEn9"j(2\VND]U){(*;>T=M`F VxAW[|]LrΓMFI" `@Asn- ´,)_{g@2IhWBpM ۫>m9t妩ؑCv.#HYBvه_ S 6# ~Ҥx:vp0 :xuY*2sS3+p> 97x3^bSƵuJWb@HJ=.)c/f9rZHnB8M^_B ,Oz|yWy1JTA6#1' δJ%Y*"Z;ˤѥ= m!O wUoZ]a94:n}[OŖխƾwtn3g~G |_SU\-}k K^Q~3=F>Xp=~MVY+Xy*Kɓ !! PLֳƉLPm/;PD`fﭮ jwSu m&1QhNsE`]~<^)./;\6 tL83~|ƌvJ=hw{>z_ʈ/ʞt,LҼڧx{a:>o*ιA2LܛL_n.Ք{lWEiΦ/"rHe̍~]%|Vt(blO n䁻_~ա-y网 .lM!+%65O-|I gH#ӳ1}HٟHu v$ H3PzPo(OW4w5ז4/49v} ]@<;y/[?ٵNV&H"ϋ^kwޣd%{pˏ=D/eCg)I|@z7H[% P~6(}ƌMF1auM}Y_c1v4 -v# xX ӈS} MTm\Qu=;B'ZC:*Za\u!EDQ;11Wmss٪Hoץg&k%Eݬ)XCI-B,/,AW̝-QeZT~gFNx:A91}en5bm2$;(k~9PX8w4]V.I] jGGrWS_nKblc\s&rpTxU|cGy!3KT-Y^odY}׶Ϝ y;2s8]-yY$x-4h/$cZaW94֠.Jޥ{3GicAd%u~4OL$VJ0sX/#W4¼jdG f${l`&0m@5ӌ*8#8Gp>' >z^|{W}I zMjEG8@e߉q ѩQl[!IELrT,g'_(T-xځDk_C Gz KLD3uiKz IIDsj=^P wTPMwW=;t]veJMKBs,E"d '`Z aH Htw? W0"d___f/Q*\Ifj@M3C*i!~mha-ξ.5y~JRd"K٣e+<}ƹzoVΥIrJAwմ~a^ =v=V^絒i{K gx- 'U}m,hؤUf6Q/}=eвu).Ecb?,I{+wSJ3J|D?nK(?>v'x2 ٜ=)h isN<)R",HP{QQV( T]]^wن[@ ƬjPC]-S0|ud[{xu^8l=j ma@WQٱϚS*h񞃧9ޓ0k>3ko>_ ϺŕҗE^q/uT|ݬk> 2. tD:'.x6I ~uz鿄gdɞovZCdHvU:w2OT53fUwܘK`~?g{;`3Hy)){6킯 4%4F<1A)j_V 4!9ΠyOZ t͞gP4g tY]us/KxB+$m%3Fzc00fSS-/Z5K#YҢn'!?",N/Ճ=̝ì.͉7si$E9{NMjlE|=hgn,4_6.뚝DXyc4ʚwH܅U#4>|5)Iz; 0rjV.ՠv4|D-}5^h3X/M,Qӣ6moAS W1|W'SPMU$˚'_ۦxѰ?L{0[.I#*4h/DZA>hf5KwVX;|6/ cAZRGOHbzLڍ"0T2=_]hzTDrbs/z$C Xd| _#iͺ1'x[}wz NM`#8Gp>' VD޻OU s"p}4a NKb1Tef٭"&`9*Xc3R/ sY;hk(T2cIHa&1N4pIc^oP!)sN-ǫʛ]3U'ݬ>ݏ~t\xSh.͹x%)rם?ݯz&a=HuLQ9[Skdz~^pVkV Dw -. G0Cޜ ~peNGX+"IZ<>)N8Я5Jf#A|\ f12 ,zWe[%0؛8Cy2aI.Yr#̟7”zjR C܏ ؍bA8(SsدvIv) y \?[\k<0|DΈ;S9?/Я0аtgsaiϳ2} }!GÖ[%؟xjJ)#lYY认]gMbwJnNhlKm)*KU無oȣ,Lb넌UЩMd7wd.Uig3V`ږP(VU7jnhCCX:de՞1$i60fKQvco9[S7g7FU,'6 _)uϐRqyBWjff]bwB!b\?U/]! ]Uwm @emot%~>20 ~69& sNA)@fښ3r{>3vu:rck_A7<᷺y? ~]dW™}F~=]>ϜB:𒛍`nuF*VJZĪ6afgHރ/CHp!0(:TP~>ȫ!ﳭ構8r_|Y>80lGؠl\uUt;iR?߲onq]И˼;4 gE䴖ftGBlܷ(0R$x>/l:޻Fy-)(hz&tO)޶fږwn˚^*<2dSFcFgABs馤YZnzRkMޓFJ:*>`?XkH;?z'Yf9 Zl4J$\Nӭ*E fJTokU93Ys,9&C"q5n{1ټK2q犪 gͺ4T\A6UeYQ=*6mX%LCR%;T^Uݸբj.ѫY吤Iq2ϝ%%J&\C+˩4IZ0]L;2[Plu#ޡNvkkח|S"΅ہpɸ17k{gE ٸ]R \s­J(9le{U5F.Z$Kӣ,7`'M# C~%&N2bBƤ-yc44V,` iK IOU \]H$³HW Ь-ziZ ocy!fVPqpy o%sg@Jt147s4cɚN P5' EnW *Kn(9S͎68{8G-urSKqC;$A&Q8O>8ũ'fA3H~ 3HFGeo|ғbv,)"/vH!r (椈1 & ˲B!58ֽߓ򫼝ClY>\T_?߼,-5tل%٠>疲i-aܺ Ae 2:Ln̻$cUm"U:4К,? R-R:>~^mVl± `F8"y)Y`o.a@ z:;8cpHɖvz^Єfhk2ҨכpFz 'RQRDM h,jFHwl.N#FҞnPBS/҇\IT9$Ƈx\ϼ & &v0 ' ߑf%_L1R[(QX9F#:S"0RyTMʂ%dh53 ^ מL*H%ɶ.`m!P*酪(N(##n hQ#M#hG_5(>߰d3 3^9] \faܑlGn *z3Q@w$cW(rd(dVO"cG&s:}Ky~GQ{24#  bR"f cTOE2=fU=aaau&U Onws+ [q(V<n_E1{g_>9gFy;\=Hg}lǪMcqr-{L W!b rI5s-h C /aL=1/5V'o{[Cf! Y,vl\6Ԟ>^,EܸRuo~8#kHv 6;T&8!9qzMDCDP74OaA:Zﷅ{ dإlIYם@G,qЌ Q-S"+*2_2AQ̿(1kt9ȆmOYdoN13 j<;mֻ>AAeyh aM͛0RVL|hwP!9/3ǟ F WC{hX=^t.GTaQLMU?@wf/ Pww^O|j"jEij6Էb1W}UNo{)`4tHZ*`*l{݊]0'Xa;0IDZ\yknv}r{X;lMFz\gMU-pS^0d+5K!v V׼JKwŚfXV`H6I0gzDRIcy5zKev^ j4}PCK­qX<@ƮjϞ#@#rݾ;;^{VTPX3Hi(C7#ps::[Z%bCtI8qE9/I2[vu 䎨-]5Xƚv2n5>$E*7t]2KLO6 C/2H!^HкnFq3񿟁A@K P\<_%jQ뼱{I}oR*p:K$c1)Pt-2*M4JƯά挌o>ͼwH hܞzb?G'_P]j]HRԭo^f?rfRvb u&85_ZZ䬅ZKϗrA%TY0gҢTGO1zA6;>Jr^* #Q,[hF44PGaˡI۲AÓZŖNx8I-;$+uc%kn_U(*C<*dJ-,.V)[#SBT+[JilNODX\vXyO%WV J .'24{M 㯻R-k4Vzܯ#ݰZϞ9}ک>-38H[6 Ӹ'˽>Zf ȩFRBJ ~8'&ݖ5 Ҏ(TVXP_1ڸFݟ;sNT%lVo^tN1^ ɟ@xDMWf+ | H:4 k+w$+)-\.3+\?bbm`4M]%`6ވ{8a{0]`{pC;g2K}3d?Ui*O6!Na5a4sȢ4JK!{OYCa}X*BokҀJN4rFh\vfC:'f׋̙0OÃǐ?``kw'yÞuCLe a-:vr\.2! ]r]T~5JΊM?]O;d|4G<s$sӈW J?C٭#PdxtQE)l"[e s$q-Dc'B5\L{; -/8]\!v sV6d82I'WKzU(EJJ>ʛZ%RiRlنiwo%%_i5{Pf~!Nk|DSl2W*\\TE,γwHJe!BgwT=Y.,7(E]T6%Xgqy}k?(.Hb5-0~"bs`aTE0sXJPCSw&ZJҧgZ)ƉW}ǍX=]QP̹  wju{<.oL4˺[ztY;@e9@G7USO@"TѰ2%A'z-A_eT`) lJ4Ri !k[Rg"VZ%6[B[Xbyޙx'& #G;Av䗶FSN8z1aN0ے{M#Km8sԋ&臤;.jِ+ Dʠms V,0^WϽdrRE(,HTBԪ0P_jXŒ-,ҼFq2 !`[Zksy21rZST=gБal!f S~6AwطrS=*޳}D!EgR9(3߮JJM"I>Kz㳛T_Z%)fa]wU}p)8VǙɝE`65Iߛ-Jއb/_0':9M7uz@N8"6|lIu" p_vDQ"E,,N.&C[o Lm~DUgvQN\#s6|Ih(k4t^ 2۰$J$UC-T֨c 1A0ʹk`ҡ*Q4>z-Gb){dVh[$d +ʽoJ9}`ā%WpT' CepUiafuMiڽsEqH[F[*Yk&NOu#T ;ة06h&Z䌮; +!6YS%cƇ^K~y.GY 7Uy՝nUA_G$l᝻2TK7&S.M:lpqy^=F\xqI@ƄqB9HpKJ7A88ڛgUqA/~{e4$n/c.sJœ+T "+`WB̔z NKmJ^cG9.^D0m4Fj2F"*&35_аLs\ 8vF*"CQvgo9<<8q{$-_1|&z1dHr`8b-x+4_J8n:6!='ԧy &~oMi"7'eDH:%as^[j+򧲵>*SܔʟʟG^&2bG.֪iᒞ$iMnoϝ2!iwe~3P9x6d ,pCL75 !lnUkOXh46FlSd-$m&[\2f lCю(lzM[g\tJ4E;we.l]'cbHяS'vE*HdYN/.&cܾ9H==]RA<2~+|%qfc5/sJ+BT*"EeĕvB v`+DMY=᫒}:e"l24)F[咩4Iz*%R/"V$TrZCygk5mwVxyEYac#`#}%%-CKF q9dN$}PIcwBD㓢ĩr✈NUu*^k}KoDy E@OO~0_LJ؞C0i~&0 nI˾n팣g7=l4S>H񜵫9st٦gM$iLnBv (3uu%`[4O1p;"HG.ф] ֵS?z1 ?_6372opk3h"p mWj_b h՗92pf<wΒ82-\B ,Bl zR/Q-r|PrB(J˔DMeps*k|]І-slkZ )%r,^m;#-څ+{~.K !,e.mlN]M@NM ?$͎TZEn!멉?}?""w5!!Ԝ*d> T[h='dEU|\#rmuMRq WČƴ2Ԕ,5;sI91MHeg_O9ܢS.E)) 4ؓ@7&|u|Re[Ȑ`J978pBı ; uV- "9Γjtrw5|/ b<i49NG$Gύwdzx`͆ꉜ%)Dh4m`҅lL7 0@R4kt q"oOlNvPuخcFΦud oZ*KHMJ7`VSH.sc4Ae쮲J$ &5Euk\ϓ :F d!wo4-|@rEH29tsHOhEzϪ˰"-&HJ NYHݧ>=eb|lu^=fe]Ϡ-CpTob>&EUе⢟`㇩O!Q4^ -3׀Xc`[-y=w~°I%ڻԈjG l;Xp'؆jx,%О%4maɪ)骘wṖfN$WPvI{PʸBiHâT@*l 3sIgtL%үp)9*IZznT=ύI",_WLh)ckސ\"6Wi2Ӆ$Е-JfqTBF[BkQt|ES%c$2@WI&1 *4JjT 1g?{ 9;xGiO^-J,@;/oq: P4FJDQ?#M+JY*|1=ͥA4B{xzUNiZ[JxN¯e }1~R6TCre nynM9^ڙs9/ߑ̐#;nѸMlRԾq(X\3 hՇٜ*iҶ5~ 0[G|:Cq8)pjISTӈ7*oe|'z̍Z'E/{K_Kw/RȺJNJ(0ذ< RvIΒޑ&r7 5>zK`kK$<%"s̎xGab-J4_,p,1`x3޾ݕJCj:DG>{HEX$w =5y2RJ5+R8qTI9MIB-gꂶt]#N~hMSoS"p Z#Hq7U_gn|30bXCc ;}.w.dSdn /SAu]C $kzW9 #7)X bBPGzU=eK)oҿzn4. ų}~_7^=Ҿ TY?ל sL7{%֤u Rkbo6ȗCҰ声`RaLV!N(JgF]-z1P&ɩ6'K,Ɍ] 9JH#HWS6Ɣf =$5JK J~Dފ~S!-LL+~گ@h[>hq݊C:~ZQ Z9,rW?ݹ&I5B2d/vBDm+)ĝ҂m]&Ճ\!=A#Fcw ِՄ\S鄑Xm w:к+J횁/ۓ_=du#tծzɹ?QA1^߬nm"[n2O_}QVxAl](pHfL MbN!w@C:ucT8Mu$Y,&%c3]e(鉗0 ~q~KH]F5NRi=Y¦!}֭6QzezArk&dMm(a@:lͥ^ !1 `ҾND/LcC M!N{bյWCzSOmA)v'C'fֱ^K?Al{iL;ٍ,#/Vv$:1T r"ѭY828p ܅zntc*%/݌;NU. 7b|T-^ب4[Ts\ vGPԴ[u|s1㑐OW=@yͬx:PBRKF؏eoFj ipIIq̧Bxz|ݯ(_[M&֥d8HWCKb5Z=TmIyzۉvf%͸] $HaLsQ^z̩|szR}^Pl᣶x 4u',u3*~6ML#SA`'E(nyPMMB! K1!XS =/Lb5 18+:k`fGِ[\od^&HےH;8U$ڦ /iĬ~rC˛媾8U0f58!z/I#:O -VQYUT٤2茊5ջwO:lq.i^T׾vgWNG9d$*8*XmsI:-,t.R4-cA;%#8R7ֳ :5Q=2=#~{ &du\mӶ2<񱍏m|lbmhvm1=V-}D#2wm:lX~y{uc%۳kNTfWx"sCMl<(Z(.Pp>[@:~\p7+0Mh"n6p. a thƓ\.!p,x/5\NR7|C6KgFTnAף?+⹋ EUFvyki)4;~704#gtB:'FYӪh>|a): 'iWCEyٸd:F8M*JF $# QDKcw`c9R&6 %%g‰bj<Y:#^$eioJIjKM=k0?s^WZ0u99Ţ Ιa(\@GwX"nԁa`Y]?y * N0\RKȨ֮?-\mjRHM; ˲\|q^mw* +?gR^}ة b AfS@q5Wߺ 2㜢W|ra2\/s9<M™ƒj>1&ݦ 2ҒH/s&{BLc}x#%ʇ%ǧ}>H#J[]GK+gNOG -)(5, P_&U kmv- GDi_6-% _k'*:NtU|jCL`~T(~ y\gދZE;emmddaAC8eos(v!ϻ;X~}#i#w!0Q0YxQf|Ah/IFD(r/'&ޔ%DALv"? uԺ^ɧy/W{kyDiYMj TFmS¶GסYyAS;|H-V.{Ɏ JyL:KyI쾾jZGFQiyb'kN$Y]g\y^3ڤ[NʑxT"~V_>-^2e- !~Ґ U/}^s3{6-Wv=1t_ {u^nq 5R{^ ӏ=xs 3X]װ\n2Oc5ѣ$3h<3h6GoWߏ\W 5GݾGUG< Ukx}!߆xB/;Y}Y- vm cp;?(em~ڨ8n{%Lc-ҿ5ƣ]ZH93]EԟLڿ6ʞhM@sI0/ן 3oT2%ީcA_v Q&]Ql\tdvh݂- Ca֣U ='ATj ߍ差҅=(M'FOt (eMK"9t!)6N,$U2*>[%ۊLi-JFs +kvfNv!PJhA/+)y`NBAȊIR ޔ 3^T=Z4ξ4Ϡx8sE1=1قf p6E $Vɳ~Ɲ!RF 7Drr_cO珽2c.wl<.-RzdղX],=]م-yޢF_{~MtvʮZ֏c0UqXEtWû?d[wuP}_H8u.㾜ПFm&$2#@̵Jt:ߓsqSC ѢBkt{W!OS戝AP6=3eo-{]:[zKt,Ƞc4{}~.DZK9C:<݀8M sP%Vai2;?xWg?(|>w5T\#Uc(Xoҝ{lwi/n}xJ2ĨI$lm"l9Q:);%9=mƟQW W`~>=|_eNwo |mkD*wg秷~{os;نj>O-T.}٘թ{3,;g, 44l]~ګOj:أsbDExJ5/ _9,I hx&՛amrKV x6!Im@[@i퇯 B!RţmƾfaF1oV3{l T06A`$= njWs)gDNj !0'4BFn5Ѱîs/:`v Mrqޙmg *if}~n-0KZ>ʡ=>yir #'ArsW)ƾe+6ӝ+6. &Yդ}3v ]{xS2&5,NN*ryaifNHG5aodX#kK5ZVbzcUW駥B?&F էhPPIx˗"YEfO4}NTXi23ڷ0lPZ^e99,[DH % -ZZQ#mFY-B\b]ϼNsتB&$'jX0-9Z.wgOp v*"V<9@i8vҵ^塾*)G; s V\xwq|ُxWKf&8zcD\䒁9==Ƀ7omRZ|7z8p$E~Z8T~EJJ V=1WP^,[gZA^!:Y@K6,s,!` w!qoYIQi2(2bu4dPKAXMZLRwX6ߧPV-n%(}}7TESsiLA U8Y ӛoo=cq+kJ U&Ʈ>s,E-WP9c3Xl:l2cbٯT~ҥL0 r(cn\뭔%z|S[h/<]1Ds E܇W*,2>"UR6x kzo,YҪxN&eyh5' {>0^ TO8bn=@t]dUkF8j0w_$O01W==*tğ85Ώ}oU*U巪VK%R}JtVbu0:IL5ќ;]5ZOVyu-,H}}stkF\,J=Œӟ<G!3&Ag]L|fD/"7'õAn8 9V[~Fw\jb$J?Zk~/ џ7ņ ҿ8<95a^]2xsH\(:? g+ܽFdF^egw9`/JR1v}HP5]B3/&PC,u=~˰Oڕ@& LT8ZLn TTH2bIa;3QBsqѓ?n ω`/0e ({$5 {K'uuYaGq5׬L_B\k~jN+ 6`[3LnԒȅLo' s㘼O pF}Aafʺ0/"K$ v)XVp"OTw(_c| !U}B%YbKE"9:/N_Ijd.0I{.Kf]joDfpxQ"^tr]nc1٧qB`h$1 «&oKwJCԩ+qէ_NkV%x.Pn>-ZrN:`"2C)AOSrf̦$r"ه܍uiúa!Re9~V-{_ ɻf?iva4in5di:i/`aH&QC ! (nF_dVC9+ɬ@mf\Xa(<!4궝IRrєyL(%?92HaYn{dx,!u׻-8уi|UdaϥI2uPw_|?Z3>.DрLf= ݺ¯1&]9zcNGRrUnRޕB*`< c%2uu\Œt~%6~~+CY's.hxKքD.9!|z!5l[rńJ_B(VE*ƧP vYH5*Ҏx[G[EؔζU|WE8×dle0_7Mv>-yxmjB ZU{ɜFO˟bNZ~):yr0)|ezSU7xQVR+q3be9 u-eV2=K7fCЍbLu!a5ϩEX*@*ժjӟ\ KIiiӗz{ r_xx2Gm4 ֩Q zfR{OnR'#cm{Y[~赣nCH6TBK ܨAϸ`IS*lwEi.yTs_u|jiZ6NB-S>3-I8G\Օux#W_~Dq]?»ofp {rhg_HqA(L#<-kpUpkTvB9y0oKqK*Jىƺ=>ƩJf 5'e>Ab/T6E:[SfQIeqVj?щo`(:p_UdBI2l3A${CO[#{))@9s*b|SEFS}7 g+2?vp}zc >$}`:xPS\ |iT;'XS%ihd ?Cc!/1%hHYc&j>$kHzMf֑υ%<… 4C?`8gUfM'S>$7'HY-g~\h{ʸhѿ4O55BEA8_Qx75 Y4ήpv ;jKs}.OSYuxPuͥZFAV.v]][7؉@q2-JnG8C2Su?eY0Sᶷ/`JHʐ`ljj-S(IYU5Kbn4XŞpgct sil\ 2' £Sfl_gTL52s(6kD:T5*d)iѥmGr~f1NCN*cN%Jq`)_wܘv5NAܘ mJ@bW6F֮ RiX@?QQwZ![em> jիf_nM[l@ҜuQo/_r@KN;; 8$okpvRQΊ+U$6=FhzzS}|X}z}+tUϱ{ղ  $7r t ku-GK5g`7kLA7& tֳMnBK[π*zKmr."&%8H.&@NO( sKvwRIPqhϷ*['$6-mRיZ r_xxz:Xs .RrH_[b_n:?oʄ0ŠȤK"3bIJ% c1 YCG8ICK yѬA%5<ϒ~'T}\ t7 ,9*ں>C2{)q1RBohBrC/+|,n%_`K(OժVMNfCVK≮u (^c_+|%KN;p&2[Ry]T pUOII)ԊqEgS}[}zչF t>bԖE6%c>oZvV-X,5u#Mr*oaI|W<NDr>LAdtOt@-6Is΢`qH70 TfsMS/oRi0\[G)8 &MuPN#϶^Y  OsDilZZ&mab%^xR+J`xnp<6.Y;Ұ>4}= !݋_.*lw{t88kiz-lJX0rj A3WR%94PefXk`g(&D*mە(>_XECdusH>pk\0 }ʨ ʋk洂xyQsZF%LƑFo'2z,JlL ܮ>OSyA:"0\ >"0`-;פ?[AEfP"Q-X7,}<{7D6HNXx(s0Sy+Z+Ժo>uadIr$7 E>E]"8y:ᅼ&%iM(Y@ϧ:@:FP`P'NMa@TbP6M~ۑO Q9xwo]iW'aWFn?"* ^:k~\ٳ7$Y;fHx(@SNLݡ Ϣ~qzNg\y!7܊qڤv=4 H2nwb',$~ޔAlXBWGޢ|MQFVr!>ґFhV+kB1 'K6uzny/$<Ţ{dkrH]CE&eg~_\[b 䓪Gn2trPYU2Eʢz RR34 ԣ==T/90mǕDPD@#P}&{OJ4ɐ8][HGGޒ2)Y;)G*TjB:AF./#3;|\@0XϗmUu0XS H#)CD;z,z SED#:4u8[ёTn {-taN"T*B* VǎtFV4"?>hQ% CyJ&jŕE gI0PEMCIoL)U\؎&7 W: u E}"T_ EVZЎ&PYД}Qȩ5p&'XiE;W&u":q٨yf+"'I.z-.=C/RnS|\TskTU0 O& coJc D"ĔE:xÀ+JJ@ZcL}c!TܻKU.~\%2|]F \R`w4SVK|.#A94w\@ڜ GxYu%QST7SsTʟ'*L>pڴe#h3+Қ^(w}O,SiГkY!07$;)nKh#xy )!P|sTZX=-vEƋ8p:lI4ߥ*R|HͶDO @ nE蝒 үhZ5uPE''w3"Ix@̀}" g_JU9B"x2l"Ј۠Q*fR2$@ uCCNƕSVKFjOx [sFin(*X"1)Pµ*clvȶz&.de&|1%ۧ^bJW_aqXnw\:05N*1jE:Bp`MGׂJ%^BYu9]. RN0񕏴w@S@j1 $/iŒϸOp&ZuPٶ.C=hk mHuy, Cg`5Q{e艸()uujV|~>yݺ? QOJ_GnT|[\Aٴ#.<i/T=K[ QV~pEZ BE6Dնy35T%_MXM -:aH, "?1J%¬օFuҙʁkd ؏&2A[/ 4: p&U zϐӑa(埑z#LX0\C{/}~r;I+.j޺W}oD4} tq!2]!Xu=3bӉR%PJOQz- !sWc1CDj+Xg7*YыC蛚XCQ&Sg(Ԏ@k ,ʀVMyJ& ~eh_δ+7c|8[f!4[-,`-=O0xUr',Q8/UUru2佁l:iߢ̧Uԝz"p'-3Ϡ(7@T[nGI)޺[p8T2#&) j䏉&y6%uDIAFs4M3.6(͹&K}yx JAWL;8-0/Y^p[(^$%̠v:7KLzbb f1//MCYKU^10aI.PD,cL7~@h.! :@!yo(R!6QE(%lB Y J@De7 K5xl!hht*Fe uMJ zВ40/@G"(!w ƔKd7P -CC7x;}U0.u˔ gBLdq1RI3N@ $,!"{S^`|SA՜N3jXfٙ\}12[ȭ{0|Ѱ[&mBGE$jDm]ǩ uTi+k~ep?,a?;p!'ϑjYdqSYTFNE}Lmkr}rr?(z aEe<6-2: }14U25'w1$4L!g6 qz˄{P0`LPN7]P'ٓH7&53sûA % b5'weFjTN8GQy.*)k;Z4zMPSWQg&1r6Ubeʒ|ivq8y_"y7jdF&!"# "jKIDh"jNmՀueYo*][EKk#tDcoν?HARGOR~\>ChȓB`ӹ Yfh׺a+i%!xPsK7lhٞc*qS6aJgZCܫ^@Ys$wl#DwD_V)#{ت?6$?jG. )%RX4 AAeQ!ƒ^ g.+iO,GfDp^)ZxJN楟GmlM -bXCc=L`+UN"kpkq3\LEUža$IL^2;cۀ=q%ykx] HgV Z;,"%8zf,I\zis@C ̗Q\!{` f`˪5dc$' 1RXE$8\=^*[ @RO 5дOJ>K}"'X"*>)KPLMF#CxT{[H'YH#2Eܶ9QefQ󵝣[XiFJ㕬\ JH:jEFa “ҴJe;I ՛9C }^GkEX6bSvK K13FIU!ݐN uW \Zg.W9ߔĖG>8YHLʚCCYJ/&˾4Sˆ ~ٯIv)=I}dY +"̬€;UPd|ߓIkWϺ @ŢIޯ/-]w+;cmfyvI7"V4*Q.l VTw)~w(Fvߑ[=,J.(J>ઈ #{[&׵x9 w*RǑtH:wIQ Ȏ"DB5&&x Ф^ {"kY[(,dqe[csbSۉI"g0G?AVl*Õh. Q $ӥLL<$8ʰ,R nr>X\U)[*pZҪhILwPHӖr:M:/h:+ookcYHbYф/SH~#[FexS/>Mymx<:nw-:2$Yb1)Dmv I'}tvb(.DM~ )}ƱxAǪMY),%dhPZF|},5U\t*]G)@@RSicL1Lh-TޯNSOemAٮIOǶ _4y : 3r $' >|ՂJ |eǸI'c ZAcb5N)Igq5 E8l]JX(.-DZB'ec<7ݳO>];ʙ] 8+nB*Z}gDrO,/KH*Q̶L{uHs\u^蝜of[1:36[8*Kp}( 0<(c V3B6護\JIoY\ϓXM]}_mY"vEg,cBIMNs׶qgC^ Sv&.wrT etÿ]Kn-'n*BB,оDk9aEc%aEOatE _17\<*D~R9 z@ / ]c9K1D?SO8׺'B~V1;[zəJ~]H(\$xUgJ+=gLLӴ 0dVpaO @+<ޝimΚ>g6rhdd]QSXba"K.'XLoW.15gy8ՆJk늊֑fʤ4R23煵C7],ԟUbP#ֹTMMb9{Vt'(9=9pxxǻ kUz%@kd}l7YI%_hU5` ۴{oXOz^WyL4Y%Gpl"*Vv]ttӁo3D;g-2KBp NbkgҔYtFt:F"MȆoUsJcVw h !Qɑү?=[qꩅ,Z6 WJ ǜ)Dtd>&ԝWSUҵז9*)5e:7[ ^43O CVbr9>ZWPgJKT <ؕ+Թ.xz֯k[P<+[ϤcnjVV 'vħv䨭Ytq@$dF3 EcX BQg\rϔ,\<'>8 B= _7"[j*& ڡ pJwuŒ׀àjGẖ+۷[x-K=6i4^Ң9v&{ kDIrحyf*8dſg{ ?4v~ďq?NI_=6n~gI𺈯S0 Y" |5_CXkouoYsb/$= 4(đj{sάB5KMtյa6+h$ܕz)E/zbRH+n\|36STe98poF^9̘:{2٢Q,+ق' MgkNpL ~㪫G=piuԽ?~)º;gx׍OqJ=1= 3|7'<ģ ȥR:*T]4jO9HjTvx&ώmX;nL*jYWȲFl{0tJМbI3'!SNL޼ UBYҕa}8\C@`CIn,n9/Jrn0 JoA Ԡ{?x *ﵽFTINL 9ntsSo9LcLՖӥ_@mL[ׁ$>I hBkt>9hUX+H1>(yG3 }20撅ڲIc]@&s3{'D$iFBe´$3f81.= pm+ bu\ZLpy&[5T(ln_Vjȷ<=xܒJ24->m}zqlhWETϢ4?7ʿE8 Fd*2 d*#D\=i[bAs?㒋4kPPXd}cQDHxh@(zsM]`[ u)x N ( u#ɄѠDבh[IZbVǮx\W<бu-%Odk)`baeFElJYCz6ungt;|8RrA}*%Wl:6q]R7\6S-pΠ`A2ɏv쥒d6c|G?X$M̚Zt$?Q88@Gx8|h1s_xoMeT!lQM?OF0-t@2!G"aΗdkK>`XU;NfMK{0U9#Cƶ;Bijt!V~߅I\m*';rl̀]Cp$Xz!33M#S1TD>vڠ=dNIK!T6]9m5^\!OsP5iӓKUFUR՞'/Fs漵 /!*6ڍ=qkO,J_:y1/ xQ}Ԛ J_͊/N KƋݭ"| 6p}ƻZb6`v6)p|<n$ >z2n!}ZRCHnoj::83_kxw4}WٴPI LS$VMHxحms.rQ 7 4P(5zפkLTg 6sɺt3t'8ag/5&?wv'8\9w9qWx@$<{-P=k<\O>4Ta&Fk} nоkPlv#ƉQXA"zƧ䫅S)e]čJi .1o\? w.S:0v+ĶW*̋샱vǥ[a5?ڑQN,[Q LvL$Ba֘8OtvzTdΘ=' %zVۯbs?*s.h1H*D>f`pia YKIݝy 4BOxU5!T-+[;GQV -Ȅ  ([}?{ iZJm׳|I%Φ7Ж.SȰ‰4Jo>cqԊNuVeۚ;~ p?f y3NС9\+u13ElaD3hP+XΧ6sDX/"<5XgfGžHj$xcQ*"ƝRH&Xgj~ 'X?9Dpbx;"tRTZY4 أtEoT2r"ƍ-1p"j)YLy9h(,vE6S:ٻ~#kQ]^wQڷM~9M@>39-9#qԬQ.FlTu*jj"xYnMe!mgձͪk2 )lYWGĴkū*'aUG7?: *GDt""Z=Ѱ >v ]JUlښ/;]5T%nq^(79 j6ϲgxu:'^" )uUi)^jT$SQKS `Ț%uQ{J7ظc=Wh||;!ʑ[,E4o|k>M{Wm0Nn7}M)&>V?#p|2^μ{$|-k5 Gy R'yes|yArsau3HG*{}Y+ xvَT.jZuvu؄M1 I&-u/GW5V"*!rDzoM\ (Hz37{;Sȕ"4ʼ0#hWE,d14.=>1fdHR~u- b͊_ U5k([T0^h=O]ϫ]jsdػG$\]);Lnc+KFi\ ;e[7X Fz6lI!ed-dHWt:9 ]V+"?ɪ-i[j5ZOq"; K`! P?։>Zrwh|!۝xH DRtx&XCp#DX2P=4i`82Nw>BuŤ0iDuueHW1rYlX]JZ(&^iv@Eq$🚰b ßqFiCIHPAJ a+.AˤfwaNmw)жrƳھuFHv6'v 6^QheMV;/u {3VؤR|GM>fljתiyR6__VuōAedD@JMD ki-BXQ+kb(WC^ΐ,䌙MԬpM.r+1$UjbdM[ϝ| ٝ]Z&eLoxڊj瓹3Y~INڂamjX6o=]qg}ݩ}& Oۯd1;}^$JUgUUPDCo-` Ulqx{{" ( -?Z?g<^{d )p:=&W\fʚBTKGOY+L*-}["[jܮ{ڭuGlC )S4U r`^Z2cK52ĚQ7A :>p/llyNjkdzΝK*N/Hibx#M\ -KRCv?!@v:~ 6y{ PIY@0*?&"QǵK0բP|󲳺VG5A$y5֍0^-uxSPQ;c=IK&4 syl6sTtE[ihuó/p` URr^ ՙYyIy_Sg|nn0OuU7+Iz+<_iF ~ۿ_20Ńa`N<}SPMF]腻S"4p-0OVP=NlNqe&}vHe$.vS"taq Hl-="q}_SHg3 BiTJPa% |@yUƢ\$i˄Ж2j2yd'aZfe T '.z?ix4eT$=D@k{+,lMsk`9qPN+b?jE1(8:PjU*9vP@Wm\@xXz`H͗IgZ D;YpH΄g2d)vbh?:oI\_o.0D7n]iV ؇: }ӏWt?Eli nUߓϨgݷKuG"4.w3}T$_skQ._t4R+v!cBtV2dvSS/:.\gahj`p'qg}.9^Y\*ЧKa\N{qݖ+ "X ;=]2Cz*I>;.+*֕;a|Ad7QER@gWP*LqKYi,) Թ$,_۩;FtFJP. $IEt Z c\RQB}4lG$!IV^j&w@DýɰSPktmLU=Ԕ'жdp_BOҞt:0P]f4<-hN1({-^S{PK fFtKwFNf2"?nvֱ-6"w\U'E2s7yFO-LW5 *7HTe[լrҟĐN.\]9NX+s9oOXd2<{ pƃFFHe (yU岒NVuQ{k~aJ}sQWppB␈rk׊"|lZI :z:N\:Mik1iLC81ӣߣcNmK:Z0l9dk&/K KMbp9TUћGC:|}e?֝BCn˒qEᑺS gW-Xr2VM VI?ǃoDžM%oₓT~lb"/GjcӬԲnm Zc76zS']浶uN?y@E U/Cklġ:1 c^ NUQP39ZD+GS شp"l@hߪZ!l$m )=A7b|ʛo嘈 (|yibRYp֔^ =E߰겘Zv;jULa0pFO#9q|1?^`Vӈ⑏M1f2GΤ4 1Gu_∈;YwҲMc*i.K g珞UueuP=frmOQ܋A&H)K*IkۘAƄ+?{7NP+\3cM*r`H˞Gq6.$aXbp=ey]. IhܒT`t#ȸn> "#Ce QY8xԬMz+0T}QaЭQ:Ua;9D|<Y{Dτk:TPa%).SO-0֓F6"DAj8p0nQ7=PFC$U؆~'|)#`sɢb++]MBqUMD3Q骶4cs_x 'TWgȲn5H˜oryRKS,P< 9rs*E'r80f^5=$>&MgǏ{NI3&;.1_KK7AyTr^<&ZjH9 q*=VڑɈ>],jZ;%qK׬~Dȸ6㹒:OPH@$E.'TDsȈl=avY+=jRp{IN,}c]0?޹N5ƜEq;2Y&E]!od׈b3 PRٽPjTRQг53ƏtPdJV}34钱@d|MS2%sUßV[7j8v`8r& հ,]_ql;$h6_ԖT{LBIO,@EtykKeu fMQ j5L 2X;[.X rmL`Wěʩov,&g/h D%X ySvǼFZ)c]ڋBa՛knutE1e[cJyhW\ՙANޯgY158뤏v+xV xO]Z;>gCO 9fPQk 聝YIZ[{u=O6W e,5:)Us,X9{g8odw]97prwbk 01qI"').Roq&D7"Q.wJ[i wGڮ@kBN;h3-P!.`W*SqE@~u5.~R/to|Q1گjiJ LU\.g1HԔ!TπU B\U)?s<j73^U,֎[\hn9> E2a^ҳZ1{̖z&-]jZyefm׸ qRd9`GaYFSR4?ʣ7FO[xS>s>@-f rFȭS9?4XxٟoFĐ xJ|+ƽ۾*Ҳ@舲5۸+MpN{(bp=ey]@.~u=Ae<(bə׉?aB0%YTfff1Q6_\)xPGI'fCGATcw%"> J,Q:TPa$)t88[`ߢ/!jce܊a|{U;m4DR5mxw^m.YQ,aeK`JY(.]LWLU牖m+6~:SawCu#p6{9:,$X}{Ec>nިo|t臣2vz<3Ѿ=ij` wPiy(. XedJ0%-UW"Ə ۢ}Έƒ<2cEk!Uum":;:5j{t@f ]< 뒆2\Z]aJ2^wJ&VfY# 6ė2 ;ތPrr5}YraQ*J/#FKa$b.ү%p;Jcc(r)[ɋy䢓@6qJ!Jxq~rzQOX?7~̐&ҏJ+=#J~cza#5a ¤rה0Z]P!JY%GD䊩ҵ%{ЯvD#[nf}-1?PZ>Z7V#x --L}Jg9uI. ԇDg۳ˆ^ E7ӃxH)[eA S.yeq$(s0og Uz ^\IU %iF`ݤIY;}jLhŨ~\ 8cK1l0٬ĵVhWGff]oǩ:/)e|fPfxq ~M]hgʓbJX3Lss" *. @ٰߡYAt(4%>69/ix@Hχ՛b*=WzhCo ^$M5}l7DAVKx4沰8<3^iR olS[Ybj;eK3@ҏ=)59O(WqWNZߴ J-0ngo BXT948:ن㭆R|ov4Ca`p'jm>;@=״}2Vtẗ|q1~ vQEV:ypav% j)Ok -zg# :Dô8KlxFiHzдAE:_]snT="KH_7%{To-/#&?ܘↇ捍$ZC إ#leћs{ lqv8Z]<7>7K<-|kn<7cX{EpO_j̰e{5 ӫRr3j$nT=&o񪝃cmTs[js9uCHڭl@ߡWCn}xҹA1V8Jj{/Gsޞc l6ڿyri_a?o0ƜgNvFx7rsg K &dLEJ}>iQ3L?E SOgtqtw? v1by%3$xbHWnac%Udnjͼ%2 ZZt朦uBNu."G*5if S)iZjwӧE%??Ŷ9^nsKLD9izy,Jӭ,Sfu??1O*pԨԤeEws2= iϯgy84 5@^gL<^yO9>X}h"gbh(ai|N7<[;w(8(`%)E̐_RA+X) ָ;8吮.BRu):Fr纬k$mWa ۀZ-#'^"ɪRUVPlX՝b~P :%[H"D,*SKY=:vcr4=mm2rVd ǭi!pOXiGq ( t4r0LP2u) (PF,0K@3iYVL˼6uf_ X4v:~#}ɚD9rQ 1 y\VzG@our$rz0MCe(e6!7[1hÝeVɸn|]6INCBq:/&YF$ ,_㺔SEe+={5=R8,7Ar&Gk;|Qp)EB@.@D);C>MD%:D"VPWje  ^˳Ԛ`V_ԞQk 6Ǚ5xwH`ZS5?G+M}\N =yŗEwjH|H|HFbN|oG+UCIYyT{\^ ԺT!3)%QJz5/]7[Ү 7,b8Ӥܯ/j[PTU6sJŽԸ/QRFy #vtRVs_u=Н2>,If (NGkL*Ɖܵ4 iܓwP{J&Q^?7@D3/)[0AVK:y1LJQ%-03X$UP:%PMݕ }av1ۗ5w֨38[W\5sؚ<|X쉶AuvBpנF0&bgA>s E9hVj5xx.yo[zF1Ï{K|/}Ey} d'зѦI4k=!Kޚrwi 6Xq݊8&:U^lwnt+oQd]3*"#΃߇սȋ]n\'kV,t1P :LjSFTY&7((3WU) tU=-ym_jG*5)- 6aQ\&,š_*E 8ӯ+:!Vcp>yT! P]@)RGY)w@?Qx~lEyD :ܪHTX:1N5J4ң/GGVz]k 0 ST {LpYHTZruawNV W4}Y@YҬ"q < P͓f4PG;BxqS?_t1Ŝw.l?gZ#IUtn#ͳYjx{Uc$ Oy̫Yv6*5_&ioז 8}QŘ I$r| Pl[C)H,~:+C%^/b SRE[H 0R1>OJ|cq2AȫVLykaa>S9iEt;t5˚7l%9{=02Ĩ2>3"}ԭϦ|4{#(*ܗz2U]o*6lK%MtP~`k%ߞ=,(v4I^`Lp,񪩷j#g]+o s~ڳx}.H%r(^Uz"-˸ cdh.1=RmbP!ޭdľtEgd 8{~[D*M3yu1ԴI ORr / ? 0 R@i~0RżQU)z ǻKd66t #a8W^ު %k2k?Bzj2"zȄ被k∃i',꣎{C*ٱb*o,6蹞'Яؕ/+1K-[g5ŮGб'YlS^A!%؈1e%VAq̩5~E'WS.qk;Fq<=ד6bN6x1M~1G*9gbLtg6K#W_v2:Yg&;I/uڡ{M4R&tRRFf%K"Yڹ Dtf.}R4 H@nRJ,~yĶtFpB@İ=e^Bae_`XkH#s +vكpL3-.]PKS@IAmq7טw`9y +9^uWIAF j\3jhv+ ahE%}蓐eww&I` baI)՟3EOu]\BjLbz6I])u\"mEu_g\V ~1zH+]oZi4Li[!!!wU!䃺+vW>\nRc/Ό⊯P0TNܐ%VLHj*8:l T`V5Y 51%S Uo>|YТCY\u.Q/XhMrmT S=s샤d}٢:=t`}Re7˩S? z+G 3EZ^گLqw,W.{+cR*T+&1mF{8D*CGc ?^orT4ZRóLΥtTVSO3gqjpV4j*|%nuV\G 'G_7ĝ:\+3BEWP'׸K*-׫B^&=v2ŏy=7z_Oϒ 0՝li7jbSt6equf"Llhø@LJHfg+q U<s z:=I7iH$X?j>ѹgډ6gWAVW–v DVd@Z#_7hWhg,hLj\]{&Gz޿?u3B(# N-I^$4kg/{9/-gt۩AoP'qYuV\z\)e@&6䭹cࢗΌصPң}%F&fc^?\MJ%tߴrEfx %X R./o%IO-љ,/mO=]&E 25P%0)~51d*X/W7'jҧ2嚝ϢUkٮ573qb7~ `u" [)Ƙ&ޏŔ2L|W&nt뎅[@6LekzÂ)6:6FjrtNz X tmǶ"]4F') ΒYmxR#qR x{hCS۾TuR S:Ӵc<Ҍ.(ZE '̮djk~Y(?ŶeoAe@P6MPĒieџݥfdjhyd%"IrDsVldSD\L2+La9ϷaPXױWA ~h-'ns}5 >1gMGH|xq/G0HC^:t+hSXHJA|0},]>ɸOLlgΆg^|%˖ ADKzѼc"j:"WP VdnLG#g&? .>ծ"rMTҋ6P;eU'M]Z]uⲂ;D~곮}Kje?YE}3f t&F~Fά+ a sv3]w^>E݊B6sK ytVTSMR^{<'6V<Gy X-vD}*q Y%XrMC]Z,}?ɦ6!NcƪFn3tɈO>1-q+]1Īm횄G\OՇk\ٯK$A˓RS6|w֍oYdPޣ}lk[rz[eݶ2_ۓ+4a9gJ-vʼn/Qcb NO}5\3jv(ZX?oRL-4ǹ!P;L*v>>4LZV "?OOpO Lo$sK]p:>XKJ7Lsa2y='SRŕGfmw*YnmfYRڕ\]qcePdk[TGe>SQ>k='J*A*BjO ѭh!zvK <(T2*+׮AKv"Htu7dXM9B DcˤвUTz&66fzvŠ9{;O_5j;Z) q|WoQ {?Xot[º"?˭W,tT)KkWfE5$ TqbmF]T 6z aWTo0sT'E[N ȡ"]uc20\Aiu:`v@$ʥ3e}S M]a،< RTܤ^sJE={!cYV0$̳d5doWN쭇CB,DWſ([uGá%ZHz&MQlXk84(4!%uʍ]M-͝ JUF'|n\vF7^$u13 ? pߥb)MZ$&/ep_%-EbWUM5|*z8O#:>pbS;9Ԛ]VvH@vUnKC<2ybԒ\@nXHn P.ERs gtx+_r?t{!}u<)#vH:xȶ[o0 -X˩~_=QH&NG&y萴^V/f !=Szi3`GGw6a[EASe&K鋚*cMG/%5O2l-1J46WY9#?jnV6b}u)8,.5BZ{\Ib"wmdf@EiIXÓ=ǕkK?([!5U7>ܑ㝱M/*=Gg>,7o/%#{:6aۇRvFL|қޚC\u;sd7/M×ę$D(Q=$ D-JY$i~>,i2MgX`v"b=04T6SD1AQGμf5 0e^6HҜ/1Ax}FOf"_/)N$&i7Ȏt*!<"))=׃=@9FW᤮hM-g2^)i!ڷ.n N%vbjչWzILlTov_˜g5!,v?`RB]/] q(1k,>d 4/EM[ΙL(߹IbSZ2 "q K/ÏR Q#9 mE!T5_* C=7M޹ oNb )Ky}Ds1(MbE57Ր7zK;0#KR8P8{>PΚޔ1.s"I }JF|Lzu\(OgZ*vłrż`FVFb|;SB uʴ&ZKIHV W."ȬU>w{N4MVy'Y+էjG1ಲMCdEal82DZAQ4 ݂,Z?hI[SN=^JՔ< ^e~@+k<ЂB׃n xq}g͜M ddwN!2n@N/ᅦ㻅heY"M;dGMiwq}} T#ˑk&A0$9w4. 2MIH<9˘V∎~SxZ<,@KN0q\xiuv1:jq&\l.cC?s斀 dːp6Cq5Ar}EW+ɪ+BI'Un\gWx#,eD䖀H?,iL*v) NHr4YLz|!ްA=jBY05H(&=wn6Yo[H9ƥ K 7 ZK)R}_/Ie0Y ܹ@1oD#E;0}DTV_84{Yj>Ԣ X*퐊A^V/D铑ʈN,@§Tߥ;1V 5_tVr:m3i8Trzii&<l3 aI3ljvbH{ ĕ=]:<h 83iWe8թ| B"78Iv堓44~xsGӺ_UoȎbX$(0 u<)#v:=G {KQ /yp& ؿ(EUx}WXU/$٦]7çbJWQ2&Zr2a#/V5PU1dh`x3L %P2Pz.qݸ9-=CVWtbw[0s'Yݚro+D5$z,x %CX<;fi5lVIƧZ$ ӂHkzR }DLgIm=ElZācE68H&F]dSOaL I ]RYC݄MkI6*!!h!=Wjy,VRArֿKe'^7Cz=_{zIHm=1b0"; pdN=e⚐7ꫂ~äˇIVUU$⒦ëx42We ʅI}-Ml\ej n5V3OeN䅊Y~5hH>6wٓsJaI9(wxH\R4 `)UY ӗ.)RI͒﷪C8ߢ6_uE }5ѺK@)Ia 9yقζ:hK+3?)/k>ϋG*X24$fn}Ml|^q0*'𿞉OAϗF.jo*Zy w"+TTnA-1H-iS8 h$ |2Vkf, eDhp)uCG%Ƶ?Ί7p9j,o#}iȘ'2K'YS{ }i%qz"2UfaSt^&بI'<*}I+zHh;.l jؽeꓥXGQ=ҸpO=q+$ȂZ[GXkE`ơXױm}Snq7r>&䷛vnMa[#{H-FAp.D1'* '7՗2/CVFu&SeQ5Șke8iRf;둑)j[]7B5.eTlȲ;EI 's, cR>ձ=u  ,yAulBZ`3mhm~ii@k_f)Hg,wE;ei ޴R/J:ӶR!WUl3^;%q}d |twL/;3Շj'Su魍MjK̦.v:C ܇ܥNRJBXsETGE U{' ZT KSKw/ V➊gSO'e Z諮 Iύp|Did:W?)ɡ$MqEW5_.X5_y븋*[We_r?JHQT`,i;&şIΎ0T !@=P=w\-$WQjlQZ/ ͚2o׫|mW{.9<~ظ[GDLx`%9Ajsq$\ݾ@TS\p5H /G߱{g?S"&mڦwM  .eZ{Zc,X4wFyX1!\љzza}hB ~ (EH/'5uQHYb]:abq- kJ\w)(+O>TF#ǘE.uƺLTξ<=YCJ>Rvry9۲ަH %Y봼{߯nQ^oUM\1[@Bh|Cm' S9-I/б[.`ԑZŝ!N˼@b-M* g,[v0Yufש O2z3YawY>`#_{9͜Ȃi&6cѭ8`ʹAD(g{:=gRlR.`WP Ys5)&N7Y585Bh ߪWRȂkEN`?Y?YͲ~| k=KJZl=n=f;_MF" u,I+kC{Rr'*z9ԾLZ $W "S#ټR'wQ>4GHcISY݁~'OL#i;}P0!-fKmfk&i*#X?LwV E~Bki?^Do Ж<N |gr1 T-6[X*T&Vlx;iX,$@gLo1%AO-j<.J\akt_t-,L{79d.6z:pNVLO_w ~1>?cOhD:No'\ :]cCnMu[0֟_嵰#5lV[ەZ$TEiRzq6E BڝbE|!H<$Fcl3,Y%>䞦0 mXY&ƂY삲 `Ј҈ҭϟ,P"TCzwA⚡R0\iz<)Gr};_&oĶ2.+c'ָLPVlpSӶ!K]C&+L)gj~% *yLnu {/?sQڼOv⺮ʿ"i#]_2Ajv-`P๱,tuV5"K.2Nj]^oK޳t\ɭUR4@ÂFO} 'UUI0"So[̏NF#sf# K7t0 ,`6c9>m,AAi ̍!G9Vs8.ML&މPp-&ݐ $4h%h/n|'&:f5*P2˹F NxYײ0R?ac V?C8!كJ6,MShpn 56Z0KClk;%5YQћ>+]]xM?[/4ɼ ~A:ɟ.SNR 4I{jb'6=g1URh}-X*(|kYgY6 bGeHgtdk[[jMv#`ɔcr(i jl;X%4qsD82^qUXjVͷYPkUxY#q"SאM7v:ch]cp}0"s<_ɹ]h-9)&)م!.8qV7-dߐ%=wFFb´B̩RS fBT&E:$7JVyowЪE:\u,ctn{vQ4Hp<m*J;,D5roRT{Z|B*.SrrB^/q a|]]QSUX ஓ/&U|f^w}5䜒fKDy}j|1Z2aaaeDn>T)jι$bg>,u?=84BV.>dyk<5y+=7*A%4pv ;iٴy}L-mXdhP Ln`EOJ ]]Ug*tYov!qTU_g\t{4pva`W96up/.ԄvCRg}YO=1/, uˈj2zΉ̼Tq%X:eU/WD$St W>WH$5oFĕ~C 6 .We^3*uIg :*%T%Zmm,Dj悠9Zn)c6V䴑`'͕w2ޢ}(<'ԦĽQ/PQs#ܠ/~=CK # q@%jL@\I ^ + O U!x".zwtA/+}P:oN 5*[RU3 2Հb/qJ`RDTÉ Q$eW'2? IpqkBH6d$h DUW?xkA}^ VN s֨10c0c0SfgP Ɗ2zgSoT.gۊЇZ]w|l=n=!*jkot#>2[\H>7rPj|,(SQq2U%S#yRY'w 2i"ɂ;z)ү.q> ElNUJ \v<>k&zfUZc0 ޵kP9]{@Dkgjp8C@q)2ϊTM`@Dhnj ]F*6 ޤXz*ѡfk2=g+l\}!^IY&0n౹t-4 q~S+F* /gNHW , cw\qW1/Ɵ={5HaBQ|Yz"ήđteW.K$ lA ([/g gqRReaj3ZSYQ5p|SFςm=1[`SxR.,M}N@țGob9'~u"ϲHx?9$!tyU酽,-f) 2Zx}"ZtT^bq*1{.q14"UTĶBL(uHZקFzTђ&‰A#՚HuJmF˂jYB]47=ιx$ү}y5FMɽjNlQP~-Qd.]MF?,GYKS8š04\嗢V/3sO%Ϩ]o~S(D!(ʉigywd ;EOb DAHg7i RUHz>W(rJ{#Eĕ#%( lReMcgY]V3`if"skd )2rJɨ$q aWN8FqDo9f5_T3@8A#}exY I.,c$B\Ho%j̹}כp?xzUHt-cHUo<<;I_&Ir8)ymm9z~n$IYKVa@4@r[:98en P|#5 z'<PFkxb _N>[!p&Q)R=;A\Eѻ!AIvMj-P"hPvci[#Эѡ2h*ِhRn-f60hLAezi{YO_dܿsO=grGSgRZ&R:Q?3)IKXMe7 IBydžu5 ys.7 !q+`)4No#KZ/[LX0nJusS5+)k3BЯVjx}ʪʪȪY7mÕ7!=)ϕEEjxM{F dQB,mvJ> C68(N%2ܠe:Q X8otuHXf@8  tO`o~0{H-Șn|f@6*.rĉ%E1iA>:~HR~%πY1⪂u໠zMv7ur>Iᤄ4T&+?w X x7/ҮG/#H v+rHEKkj^ =6rdxDoDO6KwifF' ,| PZJT ^5Ĩ$5LijovQI!a@ pVVASl3fbj䟚fGTX>׈]m/}^?I Q~3>M VWI|OR~h3OkCb%+ku([wsj40ˏ7.v=gģxH@)} Ӽ%-E7)ԭ i.5 Ämv Ukhb>>,ؘ9(ẽHAUBy-e"XJBT@0+[ŐiO{\ 7B!帲 ?Խ(o:.dc.fŶDeӷ% ۞cs"sbhL\h(?< QEo+Ь Y*Ѯ/=CXM^ɨ{ x Ҕ씓 YI,%pλLBTk0sLXj1Ql[ \1 RUU%գRa- ܖ:NC YUcQxgvU*wUC+[]l=x@+.%vKQl hR4T&R@M8xAMw٠LVY ,ig&XnWl43{qƑ;yP,4R[F2uhXU0vs 3fZqo uŒH. Ni7p tab3c׋5vyuY:3t\r") =bj%hqdlѹyvcнVbN)Li)K+bIє *+VR`bc̄f&ߞ꽾zcF ͅD_NjGk7hXO@,Ml<6-Ek@SS:ϘJæIWLg5%^;q!QBwmXUbXפ]BeHd4/ CM WE3Ps ZSZT|N%1(!~4RAC}>1p43U#ݥW'Fqw^y27ҽj}Z+qؾN !R?< fYll1S/E Pn0L& (`b>G< vuρƲ"2ȨE18U~mK!M-HٱZKy_D$FZ ,ERra: whX*Ts_Lb>8Yf$ڒ{tuKUXBu\l@K_vU$.h)[C9y[kYK\.uѢ$Fcz#!b^7Ug/|%,>#]Qѵ(}ތb's?b0 8B&0DDa1STU{c["!< L^vL2ZQY쮨*ߣ F!qMuoQeET`nr-u L?E(x;mhjSXjnCV90\Vګ Xo(ˢ9(LUEVԈE©G*TRK6~}1\r u`蛶6sz@N8/1=[.Rp_?eI,1&.= Ѡ{{ >c0 1eSu&X8tmgcvJYP<7Roe%GZ&8mI0tXKaյqoeaqAY=W[2]'viᕆSe<8cWz1Dj߷r}ۦے?LkrOUI6k:} qmO9o씏[g羍I {>]>ey.|h07!Wك P4D5؀œ{_6:- PW {DAvR4V"R-c_U\d~'7o,j =ti)H!%IXQC$!¯'gH?2M.FNd"!=1΄_d`4K0o/4% 6!?ZGApu7ֹwò IZ4lȝ$^ASmT; ?d$E!>O#7$(јV1g).9Xrd,Y44jj>N iYM YDvo5HE-kXj£E_~)\q.I76`lYO&A};1JWOQ} ^#M/W_8:fِUpl.e|r(ֶMДZa8q*1\]B5D1 Z h 8tQ vg&oW>B!K R%q)@?{" eA?v ."|kq46NkecPsJoTP>RF%[dӒOa`ILض}=KM$},D o̶;~ t*V{˄z⦹qsOb}X+wM`B! (8 ?R0y~﯀}z<\01`η΂vQ Bk5tzBN6{B[^|~}OAߢ^6?ͣ}Jyf 僛}m r#l*,F{_7q@5G؟ Kw~fu X.kN?3ǎI391k!&oE\LMH}ipr]v8:"$TnN+Sp>FE6AWF󫝽ob-HH՜sҳ^nk]M$A{#Yt=tGa|2c5$g,c|$aźe ?SàU(WjM;Ɵ*e}9Yd{Jm_?ع'--jb۵Q;9`[¡p˟^S -~c7˳S\u :*Vs=#Nr(Eb@|_]wByO󭤢0=ɳZP(#^.@)c #Rٗts8Գ5l˥+Qp&Vԗgi2HɒG-þ/u;G"&"07洖z7\N9I-L /C?,}4$C+Ubv`>xRF|dTyKJ*@̀k 'z+(X|$qhrW8^~1Q$42 3MA=*@bT`^8B-覭#z_G,91)$aXkX)%/smܜI#RԴ8$d#g#|%6uuxt_}k$ Fb??3D"3B O;vjȵߥ*[[![U|cS##l/?bgTyd;*j_JDj*AY=i8 +^G}WUy xfQ,f@NgQ eQP12CK;Tc6l=bnT&$qf!{bp{46jh6&_f8IgnK͠z"F*If$]Kx8Z gFC6Wz"kFd?,vz|2\\3=+\Qtd蝡-bgNz4ݘa?T rLWrآehR*1aM2dAC =?s!Οҹ|,\bx DZ1B8NSDCC_gXpIL1 ›:DX;^fo;Z{}C˅4P 54<(FG)xKL7<1 ;O2=b-"H$+ļhlz}+Ͳ2jMㆷ$2nss@ EFؔ!~v &7UCDkMʌmTߥq}ԠUGX_FHA1 hB+e<K O%+w)&cMLꓨ+$.*&b]M$%*tW$F>V!-.ԵA9邆f5fY+%\!JBhS 8Q(d=7&T0-K0 $땈RmH,.L_XY] Xyt 7cuwqT՞S 9v:N,akK (%&SFO -7HYB3NUS{+Ć~IfJOe\6-_k[;3M [#-_Oz3Ȯ?LK:{%K} Jd.43_ԀֺU,vyV~V%{^]C2;<|7 /M;OOS8Couc1CSNA 9Qg[N 6HUuH!dzɑ/o+8ҾbW.fٟ0˼7,͸jyî["hjDĻ Z #Y{fٝx|e}C.tރ{y:ҙk/]m{]qBګ-YH=]P1V>HPK}!|{v,Dݧ;!cHPޡ4m z)ً 7fYnX> b`l2 <'z3iL_U/sy֊X'Kޟ=bR" ,o)o)o)KWn4yH/vSs &6 U*OK7:@r}>,4_I-}2: W7KXu0˧SJ8ZW7{K o*1bruM nԐK2!xPGϵ݉ՄibVL B_/ zf6>ΐAUTDj{c9)|u\wP$%4_Dj }#A])e8EC=7 vcN)L) +_C*D,%ESLQAJ\u@3qyzzoQ~|Z֕&W夯F ,/2M7tecOחVZ%jEչ7%&82k$; T|Y 5iPe;<Mh8:g2|&r<)ϣ@@t,h1? |hf, GFϗKo-S߇kn&ȃT)dWXlj8@q/+9;w)eCfh$p0ʱ0 Z amf(u$NȢ[ "f瑅O^dyb( m\]skqE&P_btXI>qoϿ䬿|y0w[X˵+D,:q2Z16U"iʆl3B Ygue.\ˊ^/5̈́,{em4R^a˩H" :p.R/=e򅆷>CVoZ_;Oz=N`S:HvwI!, ίBfIoӽ)'=NEUuDXE"S]jh*]#o4A3F˲zT*kKEaGgRCbV6aU]t氨r Trzv2:HxSpe Y߿LU2JjĤA%e9SPi:شsN諶Vr@N8/_t2<L2Wý "Q^,CCy䫙/?w7,pK0qJf JUp Ph=z 1A]>T(':B"(!e¬m"hJ,M) U7+ҭܢUV׉`c;]bUGLAahfLM46y aеu]oz[RVzXjgo q|r$/$ `+*ښRNS[%0lUTTCQzBկ#"${Tw2{)8 BDKq]IE?9s8z)\9 cӰ'$R,az6zS[KЖH/m+c|]v#!FX>@oj=җ5bfBpWmcg3XTԖ%-n|$]ى7{e]a"Pְ A΃ݓ% 8=Kג.|!{՝_ ʩY VવHA84PDbEV>"{*!5R zI[g>MLG#Nm5 Bՠ cLZ sV 79Dž'Pj‚;֟R^jB?I }iNԜneޡ\$cOmkQC>W(01B|:@(pW}nk(Ǹ c+,\8ԨR)1 0(wqtiHt !%^("s%w=XoqǩqNS={E҂KiFA E_IvZI"k[Rkʄˣaby$2ԲwlQZs/* >TӢ=^ mp, r~&} tMitC[Hq¦CxnF ?Q@WEG iSNw4DFuiwKz(!qa)_-좗+],lfL58Oj\#_uS ́d5HV=}eߟJȑ#;Łޟ2ͪ>i 5nue[S_RHg)mVibUmvd^`f6#8eaI,nʎp\ME]¥"VxZȾ/Zg+/ Cd/i޿f 3V;J= Ӄ@g`tޘ, D]߆m|;sC6*sp(m> R;wF},H&=m`_J4:8{;8$ r`fyPdV-̓/rVJL yyUp,lwat]l c?<5nJ"] %ˣ\:t>.&`4$kH%*5ُIJC,ɺhv,z'#ߧٔڶ?[z\tEo͞;'|4"kݻ.IF4r%OTCOEÖ@jBC`nVԡȄ>s:uj;m{1ٝ`4+rYf*[7Xryx4`B @f[F$ vvG3ERy /n(;={>>9U;e=ullYzDd.. ,U[@kCŠu#2Tk{^IuYLŒ⊥>Ȝz{z~5yh422E&DaAYBȕs3\&0BU֐֬%#`*pTֱi7Gg:j(NSkŇ j ř>{GEQ1a0Ș:o$vDD_﯎99y:?;ZN[GR>` G5Rgrι<[wwø}M-_2֋eK~"#S z1u%[7wY~M`8JesdGaW@O={]Kuk ؈A.> $22(XA:ZJGi[6JF1E4gGY* Czo~?EA?5%*ٓ6Q}4yrtHVKڎN{\ 7-L9q83-t]@hf?}uMRZ@6"m|3rL8j{\eQD7;+kܰ0햑AS µOeZi9R щBE\NH-_ /d^K("ڻAך?:v~萸 IeYH3pY j)lצ^MUh:`{.452Hsqn@4ViSִ՝KYrr'rn=ar,qC4wB;)G% 0r/_~gʜ5h[s:2. EHtOEՋyF؞qK|'/Y0mH>$}*Oqq`yAPwx*O+k%6n jf"xº[!ޭ%;)WGwp~R#s@gjmhl$-v/+"A19HCψq_rΪ~4\ČAqsr :gq/f0UkHy0ZQl~=$?qgt3\@wvCPu%W'2]Yy<5tF֦`Xp'ݯö%2tJtH\6h ƯWTݸyUKo33IRH6hȺ"+£Ja=n[4q1%1ǁA*BaKm6݆re1Q.}52&uVX>HoW\jrZP-j"(ԫJ¦rӟ4sOu MKu%9^z jOQAQ oG^|x=Zg[ X9n;mpgiwsAda4#:w9B+wMGt s~ }kNF d:0x_K8o-'gF20`QZZr†:muf]}js==\>؋ax >g#Y)OK0QbA(LtŸ~xa;eu ׳Oe *_9ʍ`zDE\NSxJ19|^cdAZgzfUg`lo9~I 2 ֦Y}JN+{.ErPʼHsad% -h\RַuT5A[OwT J㬞8rB#~Ch\Y(%ddc)kWIʜ5hqv'•zqyyQ<~4#qn&LfeYtK>r2 DTMlqaTpl9arb IVu{?@.JXo|>>dYGx$xqdċ6-)V8cʹ hKU. Eڳ*@ M9EJ<䌁o-dm,tIэ$D46 “hԟ?}"-Vx'oƭٴCqwC}#\h=^KF׸cnrevrNy6*'GR?=]`x"z8 :킄mha٠jи\dzڱ4١ _HsJQ#h Ez Ts@Η'Wit9: av՜V cZ"(4M,8@QzS)IP z4AWԵEjSM$O)"=q[S (+6渎&*Y V4$Kn>2.n u).5ša\UvW "*H55uCysI_%MXic R!N}4/RA]@k7EC".-.x[H0[w7x2D00LVFv c7Oi?óvFo3徕Ntpj߶ ټ{,?_}hMPwի@g!Dʢ/D~6oYpDiq%hhݡ=:%́+2KKӾw*=RMsfjZLcʈI*g:.RQO"Vz8KTo|;b1>e3%ZK148pC26ž xgvE E r$`5d՛jѮ7=%Ū__Ng A*C}k  Ma}3RsƟ)d渄'tf7{ גԱ PU-M(VGS/GgfH\fUR\rXү-ܤ w"%?].MKťTYJMo+ۮ]Q:].~+%XsvNX;:HogU)Ki ~ RodasJdaCiW.))}Ԫ/5r@Nq.uwFhc ,zvmޜ#B{۾Ege ;wF?vS%INj1Kp CLeI7? tŤ $F@_@K_EҼqq8O; 7>*H a/_~gHqiP%ve"aGq_rFՄ(MNҽ&fEԻ/Zoǖn,G7h^%GD,_IPuiq2MggxM=ǵS԰## ( ރ?[X"/u[έ*Wb&LR~㑉kbe(jKW FDMi~9<. w<=Uaqdv+s T'OmRxWy4ZÂBQr7hI?9N 0%gB'{,4\UtWb%N.{ړ䕎Gu&gתn{N.I8N*f;#B.p=/muòoe a鲢5N ,A6fd~EBqۓV{bN),5vwWycXR4t/1 O/\ JhV3~:d ]@J~PG᢭edL~4~߉ߢi Ԛ}\\-J37SբMe )wkZߋKct4zdtÚ^!eٗ\XFo $L(DbIW SlDK܋TEIXT_Tm ҤNopQP džJ"S{EyNy9}Ke Zd .erȃt7سБӝ)}`(}K(J"'ſZRڪ&$.3#"l!%Qt(QMpOUQvz^琉bMI|\2WNbY@q&т]u=',qIԁ*D Syh)d1]b)TiWRSl %4}](2 8-jĒF2y@*\PlstNvBߵ뤡7.)p<~ss7RK ڧe-ep 23d.[SGiy-,aME@P9yo/^A˱k0ʦ2P`&[\yD<\n5ddl\!BU r"癳}%HT~c)E#L d따Ml<&] om G,*iڛ:Q-vr`Xga0\[7Blp #K R,oW}\WW0^z'&,RNkm ODhvC֫d*<343:㕲&ue82{(F2BWs =310#Bp$/6~ Bo䣊v[.OqJ.mK*.#ATV)'D`1i1}) b*~I4R6EhغKEQtEtzң$2|@lWpv\#%j4Y:~\͌Jq]+Fohiߣn&|CSX_gBΤ'f?|.oJO}kMrpІ-,wpXe==@h$u:gkڍ4_H}%2rK&K&`&G-:vTn',Fl2!]qRk oQ,ϥU7dxOȴLhl*|;ƪnWkOZWYޡZ"Ѽt-S}Ј`IK+!;%V @{o{*VTTDcYK-= f\;щ)~A ?q׽kӶxb5z ]Dhe6 Aى*irkQØ啎a#lEJc,VҡpZ!c4fm ȡ:(B"rp ߻/=q3y4g=L'-a"U&}))ߨo%p+ L]^+YC+ToW :ґX_b; ,)h C~i&B+(5Iakʒ%Rߙzlpx05U^4(V9Ɗ7Z)+P_y5kol7Yy[F!tZ !fF4_nC?ַG9T_ء;\nUـU #z" }.wZ!nF"DY502G&7 ̫D_>VI+tWCN`_v66lcŖb=b!_3nM[=AR6:r]::##m&`׆s*Z2RRBaBmAy>8SR^z^7|5TVܽҞ9T4s,uS '/?L"#O֦M_gHI*DEˮ2n#;β!uk5za  ͒PP'щ) |WRpJĴi-> QEg7ihV[appn [$].V} [ ՂchETE9jb˄-PUZKs2y NZAZ?֖#څ]Azzl@ItxP ^&Yoeˌ3ؗC̐q%KڊF`^eO(A92 lWIg:ふM8Ώl0C琅+=Rβ8&#!Q/$-w oI]E;F&KC]B>lɅ!T\p}Uxf?n͟zg\O0?r+tj%#\Ao~Ǿk-^<+f>vq(&\gz~dkt9zz|~$xIBҍbW'k*2;[}:_父zo|ǃHEy=Hz|:޷S(Z\wI8|lm[_בVDӣ(kV\=)KPL=޺s`E2߮cޘ\,$T/G"ooudYx~٘FqIÅpp+PdZQ>:K(I`qUgh /c@ ) 3gRZa7.-tڕlmn`EhC/$t }`ɶfEFJ/O/=ȧX2|<.iDVtF2< ]gV U8<܄Cmg Ƣ2^\ ]c*!Q$I x\%Y!XiO+2z}ֹ:y+g`ބMD#Q*R(;/SP#hzK@^CϪ>f扮)1"9deϴ\5aΘ'JRن - rns(lgc5ۥ MH+)Zp擨`Ӽ\M?+m(yVLS0aPLdd^rQW֘BvՒfUuzCtݷ{te!hX ~ܘ2 ?k =W~LgESԳk]5-nm1q$!ԂU[u8 OUM3i[oaǸ Ʀ0*R(z'c퍆%)5 M-PMi!*ET۲vJ;*M M> N366M ˊHΥ!JAi$w^s9)Sa8tDեǽuβZ3Ruq{:{ƆOFէϓvtUxі&rzjnZbrY|ۃ?G畈6&Gbhb?ͺT;L"l9{,$t0t01 Jƻ*rK5b h c`DAh,RLBftA_P{͆`DN \X]ͦ"1Ƈ،!NoKh>M4UkʎW~hSF^QkWͼy4TSdc ڈy¿ø&#љMԈNE5֗bL&#1M)dǤ˂/ILy ԕf0UEET*&P%nd|y^&w~t!wꧩՎxbl΂ɖ)qKi-[$'H8*ml:Rm=CEX&*Nv{~e C{1qG 寙A<9=+O]1:s< W7~P௜B"x A;zCۃ]'cgcy/k aꯨ ိt$Xdwͧ'}Lr}?]2i Kq^,t%`m :mswSUaRn%́9+ɾn/?tY?| Hwrm<5w {iSIl؇6]~2S: |0ݙ6Ţ]=C Եqt9Mah*KH^NSSBx~&lz3 }%=jFU=`K2ZUPU5$<*TQ8 /V"w!Vu7Pk&ʳk,) KK IQW;q;댄ˏueYlV,_&Tb֤˔* Ŧݻ4ͧ*U'`Z)Ë8~*rl]7*֒7dv='@]…(\[ C=oF֔Jߕ`U* a>(ٛ!3^p0s1^sם_jwj<.ALMt =K~ǽG/Q1|(!ȫ=Q;$إz&%bmj^gN޴?G e>qoZհH.[j9Yh!hXtK>qƴN<+~6n~Wb' } MMd밁f bFSK! jt+֟p`j,v pI[˭Û>nCf-) ETKF 2rb,3 [. Sk0hSE9lW"OUKu b<` ]o[!EZ w&7[4Т%397h9CpD݆OjtK TA4@UH&5g&Y5£vJT6FYz$0YWf1}Ha'KYU v9ɬ3KZ UrtutC$6[Fb${ bNǹ %$Q]Qo`9fpw RNTUA^F}l)hs/*|(zF.g]TPaFPJ: ?w{!ҸI|p>8*oÝfAcbh7fK>fQM$",JMU+4 9rSˤ;ԥ^`>?|(yZ/\InCyB(?`I)Q~By)$ hDIcj$N1(X~g$7 ﭐ*V,Q&9z ~-a$d%]g:p#P0!ܗ]/2J%+a]_wrpg4V=|θG VQ/=j?#04xSF|q/R Y $S]20~80:\@h&ֿEb' vRk]qI&aa$)ϣDӢ&1G8ho՟%)Qs@OOQ$,LTSVBF #(idr@==-=#P5Vlf>I8ǓGN#@\6nbn#Ru̒Q| ,MC˟)SgBF\' N!,%gz4XnozOX ri:M4Hϳ?Gyo9!S)fE^,&\PeW+RϷ,tMPq7D> ܗX7ZL[,NdˋiYb+gL"c&'W*F˾t ꘜ1T峿͝ u#t?bԺº9H!N2\tE7ۆYx>]v( ش*mT%P79<8CeEɔ<'*iqBzN(lY(Tcz@Zr"& U'< k10i _*Τn: f0-5Mѭص#bdb(Np@˸YETFRN$STԦ\L0GރUʗg׻ˁp|(֫:Zokv^śtG真)xIܿq R;wѓ SdkrZ2VZ<|Unltt_tIR͔ˢ%0ԱKjKB%ICkd')nk݂{ _hg EHFZ{: i[:N f*R@jyg2Gg .c9(y*M'5\ 7JC7˦*)Q|*K%"hhFv 䖆(䚅Sn肖i)9:>eϴyuihv5yDW„9@ltP u`M2 )1MLP` y%/ص/OH Opk" 8ΒKp;. ӳ0'~ݕ?!e{TOArkfb(ʥWhGj2:jT~tMT:̐Vn7ɢvYHsb4Lt=f5/ UC=ȇȎT7|f;V ;*m21 Cork728H,!/*R(!CBT4`^fAQFS~,WŨ{-`FDqIYϳ8eh!q{*.p%F0˅NF[GB!FbQ PQ2"ժjNFP>Xr-$ ֐ĐwI=J!*<}Kް7edv}x LF75Z ?F+($H4q[5S$eLIzQio=z[?#>ጼXG< m9TqXT)(3ZP#/dLP1^ ӂ^2u/r݊}\+YoOȈ\)b.2FՏ)I,*NL~$*J[,M␠i SxթSblnf:/yH)3 jGp+ 1íL8s>H]gNQG: 7b ~*YgW/`uϕ~dz,whpzmB)׌9Ẍvd_W՚ jULS$Yip`N( M0k|hdsD!TP%tpQ8^#jU:ZЬ^z, "\BvQ0Z[kA`dԻ:z]6(WׁėDkvS B:rd[Xv{8;Ƈ0+3:i7#g\iTrL 4$>hFvf`n;2h !҅ ]!Ş2oF,xWjeBq;˼k3 ;=VͮwC{SȁS`i I/ 7/9c)]p)rr<}lPR亢d~=Z6_RS.8ڷE~9gD6un:cpЫ$ ~^QE[>';l=o; g6Yafb@ȈF:fc6RY" 8\Z4Vt%QEx84 8-lq*_a Ḏ-4JצhlH@OΩG"Mԯ5Q&D &-Ŗ5ˁ(Q)`g-&` ux﹖VN-3zx*&r&$H32nʣPmp0y$! MU+m ͑*@ ∦t:,7C[)lEl#ߞQđg/V90qإ;޸XL)bJO3E,jÐ}_{l0*![VyH2~ّ͌&QȀݚo3%v.22k.?.QTdOQVA4R2,1{˹xɅp1jjҠv.=8gh-]08m t od*>Nb]Dt% ;J_G>—4^Ep(a4i[;~k\c=Iǀ=D:? E]aڵD$G`<C5E#`ڝcu 1rzî껆%Dihau w'@PY#{5:OySJ ۲taAfkzl?TҶp{@0_/v}I{J]աƕ0CA' e١{FlL^ SkU$"5FBUl>E4'"î>[ } YMN02GRM>fȑm[v7G%xW5Y W=\d ].?.U}~KIcbpFҌ{">Ec϶ǽ\[Lhf| dctVagC}*N.MF6Q!}0^fL aU3k-!(ꫪ~<{<Lld3rx:ɤ{='6D͑ [c;.i6ii*Y ˿n/^Qi1t4OS@H<eg)q#}▩(,c WsiGTKEۜ6[ #qN:ԊGGDcϺ'HlsMY@s|@?MOHzUH5q>97(l%hْ _+ )Cu[{PJB]K x4RKnϕQPG ,e҉"+rU EԼr[<~-Fl?=rsBXILDV6?j*FK0!pRe13\7a2YyӂNCJQ3ml߇ƒ,k%t%d:>h!P;'֤;*:/pUUZݛp 7ޕU]ʷXK M?U%m4tj83j׼|-b0o7xz21^Yˏтo@Kϝ⎑׀3gJe2f3~iTYJxkj-$ޱnJ72͖Nh 9hf3uWbь2-oc_1<-;?pUa-qG_.EcW!U j5j]Y qwX0LKA qO+$$Վ|M7">))ڕ5V_Ii+^^f$>ErXy$wDBooVhIke`Yvsjn"OEG:2pK4 aP xOT&Ƨ,#:[ŐD@I<嬋BjgӤ[DEz3jvyeG)#šmaEDFzuX 5RG"3pg>k K8Jޫեom@v M\Ӏen XQ2_p6"C;@\Ğs>OQ EdGDQ-( A[9HxCoNθуs&2\M2Za)&DxFkjB/Ilp객qqq[ek~}kM85)TY +~D@E*`oᙛȏ0vbUm ^vKâJז"pԠ@0a"Tۮ4!="҄aZ~`)ֳ-3N(џ6]E/v-:% Y%McRʚb|-TO. 4>rf3s sTi2N$詿hG"4e-$!F䛺\=M󛲜"%! 2vWyL.y7#t#iJpIHD0i^K71K 䘟k$qH=7W>}04q]&ˎZZ'KferH*CoKt_`e|.Wڒ%#v49\MPcP Yֹn]_ɖTz7[OIA@vбۍ PW${\{ʓf_}|2:!(e]AQ4Dy3곫Jii{o\-h8z| emS\WtKw@ڱNqM <~m*_)K&=T{K*Gtl B2K9Z˯05ߞKVٌmG>ړSw}y"qdwͶ UZC5͵qR좲)8ت5k†'b( ~9iP$BZUɠvI+خ6jdֈ@[lӁ8g22xq(@6Mr|lKsbds+_vBv5}m+}Dp mNþd, >Eifd!85AejUb!=-/?f*]4 u vJEUh=i(2otD%Q0En5pUX%JwG'2&G*_F\P zj|bB5TL#(a%fYN2(&d(Z ~_ko e()~V-+Eg9~ Z5Kqq" ߤN(0\_쭇;_TRMAMJ U_0X5̳JǺhɮ\5C4 ƽ/+KM-YY$}-/z񕃌gR=/xn5aI,v!ޫ+%e+o,eI2MutSq磚:9a/uٺ:81;v!$9a>e5h]'NLݙ4|S\q&ήV7Mw}m*a"m2r-T;\WyNGFY-Y]lF;x98ue}VD1PK͢5%ܒk>71G &G왡'$ iˊL-x0ַ;魶!F. eIDѫY EoImA7?*G*tɏ ?2ϔvXat`6LxÂ&A&ɰig 0IWtчr9/*Dh&-JK HE "ʤmHtqL4զF;Z p#o+4}>(xѠ:3E)Y*LԮ9JD̾ ez!.hϺM%A:}'QvJ$+⻾jg %}iK5Rs\2 6 ,sĶX6Hܒa]w o|,wbx1#bY),:=&$R v Vװ υ( DZnz~ۍuݷ]040Og^70ʁU%9A15Iw%q-b4K wvCVkK5|1BG+c3e!wu#ak~YӁ\fBs,*B/Nd-AKOr#5}]K^kF$oJ5$\V S$SFMCT}o;1czN'nlvWLbjȷ]=S$s9Ͽ=Z7(qw?[h3GZt#gr# es.8]׏?O˟Ȕ5?LZ'"ixr^O#&( P!uƌ3IL" zV2"UH*Er.=u!5F8E^Nu]cmIa9\%tҎm㯄4[!6 #'+K_˳ʠTN.v%.Q[׺<Ʈ {Oq mgo͏"]RИ"l9>qDZqARVFK`灧;#|uu {-ًeZ]Wo]G'eJlG4xAn͑=sG)Wp=\8=5AUA1:&6mg|_"n[% xj&{W}w4ޤħyK"T4JǠ M²nEPfVmtz.u`^ XL (Z-\BJp$ %,^5Dq雡',oFsU4O>9 a%(A2 >D|x2N8 zsΞ[{5rP!a Lvh?6>'"V B©3|xh(j𪉢lm"@(Wp` `Yb s - 'l LTI̿b?A `t"E*ݡanCEi}Bq`McSdFl| p4Nl<}S &Z 0q..M)E|l6}cnnVG 8IO>mem[߾hsRi{{VM p8ypeC)$K͗oT|XWMHHM`&z01%jL7x$ c\'(pGwlR{d_L` 0qwg [E=hOlMC+@FEmK*j8Mݚ~uݞAnס"DWW5e#fZ\r{>\NJ"VҞ] ZG:Zl'L]kϓQ$_R||\ Wތ6p-M[Դ[Jr!'e~W:%Oc ,ɣ]YU$))2U8i~b#RU^[lQآTT&aGmJV=m2 Cb/߁7}u}( W\;TejB*7Lm^'$mzS7V/ȩ7z 8I懀C+ 'zIm797r.E?M*{HuV4 @08H1EԒh*1q72Ѓ2 t]xY3Xu`:X7%Β8hQr>hhҟsZ8W%KԱRaԕ CĈ4hގ8\33FN*Z\6IJgoU5Gkʑk^+Z_^!,(ZT+ixUn=q`jDd $9,O{ّP_CJ h0I1\gˤ6E,Q:+$5$] t9 f>Y\\@?$!hq)b `V-!4r{EmZTjbhB.q$qft~e7baa9Z6yAlvD/dzIg,.Ʋxc[c1 &GY3OY͹[恼w=k\Y{d2 oz:7%,/(py~Z#-⊆!ժ'~ЙRG32/[7P۸DeТCM_40'{ӧD-r7ޔ4g @:a۽4H] ]=Eh (?[;x56ܧ27yUĚX'rI]48uzL d2SM! |L;xk1J N#@itOkkMVYz1 0إ5\lu)\'?_ ϥԋ2߅NY,=c Y ȺiIxC. c0sxb>(o=F纋9nLuˡ0 ]*<KcLwE+4u 3r.N s =nG#M1ʠǒsзHOOmN_l|Y*$LHqe:7< _6QA&]6*};l^[OTWQ5zg#jFؓh,Etef8i݌^[WܞεTm}vջzU^tmX#+ QXhw} \A c|ؐ"&@M#V&w߿f VN4*O]14(TwX4z{r%u8R2w 1-u@V] z?_E3qROܮ|1X ,z=m5>n6P)w_`X"D>ެ ь"FGJC#{:>}B5?!w6*9?w&Ahȣ%6|9?gC7v9M+%8lAn{T&(w+YFqZNKM۟`{|TO-O>F|^~\уy\i/M, K"5SJĕ+eQ(=߉!]g*ArߑۥoV깬;-F{oIoe_inYHynf@0iWnOgCZ*)EJɄQTѳQ|W?+{&)ͺq+n7WDY@ndZsՕ ^Mִ:[?0zc!_4Ir+G~aΰ$J\nB חd>0VL~R7d-,Qgչ L}d+O}Z7T>'ڕ}i4m(Z$P|v􉆯`-}},\w%w @DBx䑏nIqU6B ,hT?-Zi_ͪԶBEX[HVd>/ JАl:w(d]u kx2_)Id}9*/\GW:rGCdWrPۃltYDg`r!Ϸֺ˼][O8ho[*۲fF>׍2/T>}/7b*a%B6Ұ  j>K )܊ ahK0#3'A&pߦlFN}o{CŪZmgu:\H#_4왑ܑ•'M֖7H6ŗ[R`YG6\,s4)#\֒zJ%!̯ dU]渹:^b_ _*`2 x|9Ӊ#֩Xj<\[Y3{ ˹;qO?FYF:OϳeTϺbExQZm9{+;:@zi&M|1!s7h!$/J*yey4ܤrRcР 0J#`mq x(z,\A_H6@E92JwEA=G2G˨I7 2X֔#4>"Su|ǿ~!yfz;˃fhPmU΄:!lWwO:bV3( CFuC^yVrEt_=3iH RKqQᬱhXiճQNw=_K &=f$ gg*9&?,`{"735(eiW@R,OJ懸'8rC%\4miRTզ3 Á[/y9S"brȍKfYŅ #ĜRj\]fXR46ir䰾4 4|g-fjۭ~GMzb,}%[Mzi%-;? ea*Q*x&SUZň}V#}=}~lf7'6^`#z¥b=c•hwy=,9ZOEm7JxvPiG?D'9E^Eg{W_/NrN17k[RH[,B@zZ' $B BN?~1e#|$?,ek%_}˪^tuBQI\]F#u= l<}*ڤhw5_t`&(v"{ ~lyST5jeNErM*! 6hFdsRmEaF ?wd/:=ʈfZS[Qes!cbK1qFGԳ̅;dzV3gB hiqʳb HuRG['=IRKR%KŮxIpe'FUfsiRrEUҲ鮑\ѴJwO骀.AfH&2KNTV$IjJxEa^[_A[/[/[/AR;Z{-aaTcvjrww#څ-$4Yfqy";~ L(d8"5}liIϚZs/XfC ]bYN`Fܚ"IKhvAXcfu6" ]\tg\tK4`dva$N0L|TȚʦ7Z"\j7bUH"JDRfP葸YR b% 2Ğ"'1T΀Bdw]Ѭa4OKq%4$ "2f ]L39fT` )jLhika AѤ%E d4JLR2UTsi%S:w2^EMۍsN=ĽQ/Q s#z>O O?!ɥqtD/s*2snjD4݄Ձ'  U!x".zO%d}z;u 쫴(P_ %[@!/WiB}->Gă= K3L1>LY1QKhV.˙r6 sh,_)ٜ`}ڭm)DF1GX%Nqࡖ[q5 O²}cSs o>p<+j%@P65Mw,OP1mڜߎWu#^D ª ʧd..+B# ] ߥ #>h4|DwGxwUI%d].H*rc}^<_9347?Iӷgɶ/*[KVqԄ@$q :5NDKpqzH \Z0-c;N._%UӇB Z[5Dnk6J'i~#IATSz O8ϨL@Vu7)P3 td|Gy}EK\k^'J/>bC>(p#CJXwހeZ;xAEl@HU?R<u&}^MR6(,wO[l8Q Jx{Ix[1TKɦiS|Zٞf؝VL h+/riEGY.*,ҵ-d  XM:9?'~:<?fߧ܇N6qCX [Xq %0 TYmXI]j ,䔡$ [XEK_4ˮQ3NI$_fm 7jſkꑀVd@:,JY%5t pomPk_xtK ob*y4M6e~o?zp"BX3`%ۿ Q+\}SʻSG%I"HL_Gf۞*xĻbط\t!Ckq bkctrl4~I[vUDz:)aJB9՞d4>yvwgy5YDt3wSQ9fޙXEԧoܤG^$N2 Djѷ¥ʝؒK^zOhIcW_4. rE|3'f B_|6Zțb<eƪ86uCh)u` 3AqfI躒$7F!G# qn*Zp}Q NL{TKy ,Ԓp 5/{~wV!:M~؂y# ˿xp ǎK>i 5q W9m/$_[KqP!Y6{5ڠ摘O3 h2R4F0 Y0C}DU;JEr rgYEwLU-yɮ~oz4C"d]OS-i{ &g}޵8:9--འP34:-mD;ur|U*3uJZL>!O 3T=~&2ɜSBw՞3il5 ]iir]YS!H$ˮwڢJ9y^  {gyO\/m]gInᢸ؜ܡK "K<pY,{o+ MJq ЇS'f$5 V,Ai6T#qk&6vnVS|{ ȰkEa~3z8vi4W<갘9q[񟏨fB뽴XBϒ؋*]WDG1Vի޾V<:{@9jş6x*mt"dw~>}N"w2.tTwE1x呴p!~UcDžVd>淀0/esJ.'谶P$8%ntz N4b̫[d[[|>VR̨̘pd^r_.Ie&E}TJk[;yb7/ڬ-zq;JՐu*t妮PvDſU\g/%ÿdB#0@!gIƏO;·c=E2)r+J.UpIR%eh>ORj$%9g> KHa{ދ2~ Q}疸eynY,hM-[S+6e6qKҷǒ9޵ZJr;g),X)TËnŋ*kZ]*.̬Y> 2G%Gާ7yl2*E>䒁9=SԽ9_M^xxl1;(tXK& ,F2}qBZo!vZgJ?eE51}Y#OW~d\4vX_]"h.(s ^3HE3b?Em ͷKOж͊O? Ih2`$xVڵ RhF TN4~_)A]Ƹy>9J/3'Yaa3#`d} eBȾkbS'y%i-H@m#r%\ZI<<#q3ne ;b>*e|izKcw߳Ozv\b?&舒TT1︁'$N(j0x˟ݖ5xmRڶ!c.yi-mS8n 3k[> K0##=bb.!2%пӃ`#T֝5B2W*fn`)`_݈nh;&?5w떮QxtDׂuk{gU z rBJ7?XzG:K[ ǟo+Ԣ7^_x➞Xˡ Y@E(>›(HoűSin]h@3:2x:8'䵬5)4Jx=5mqcڨsuH^IUoq=d_=6:ShC~jGP{@=%zacγF\- T39d2RÃ>1q/@ T*sjԬ dDeB|*m $LW&p@K8,ZDZ[Vz)Icnb1Ҕ9U%kA+q>hxE2 mU9|$Zֆg:= 73?J i^{^6eva?%Y!NӺcMv3uWr*h%L ?,t'*WS6#SyF=NA.T,@a-gS;dZVKhl,ja4(mlV6)y#W4ߵ%*au6|Z XO5M&Y13x6=@7X9oQߤTsYTt stm54⼂})F{]ʌ/@I)ʵ ڃDW6JM[t~Y 1)_&I6yl8@2Ei/DzDEdV*"N:bpL ͳ0J[WQHc^]vG5F4hIXT-ɳv+8rq.ejc*6TiJ8*t͉,։X?A\;;lB|V:r@05 |",&3-jYi.} p{ B/^%mJGZo+vW}\_gީH"3lSR}RWQ7zS9mPt u2AarEδ]É1i\K|S ,>YJ]CA[nv#^+3:VmT|=S4' :i<)^k#ܟS +MFfbys\R4UVAKI 0 Ybv:Çh1\,@kGVQ+ʽKxk=RgO$E5ƚBVzR4܎u %}.74 ̑|z4Kr .48biz^i7c~UQK w'BZ,xb?Z2.SS8 h`H ςy"xKԎn2mfTII]`7+ga#kx`x;S]n)OGnTasuO;]A[1k&ºwQ{F:ir+ό;.n ER_D{F?r A N/*w.u`rц5F_RNt!`/a5Q.X{4yTnC, tG`&Q@EZ=!4s  Ě$5ui=GW msz ,yq5V2R[|<[ qݚ$&8ˑVL'F7L\.q]R%7dD͔Nub@t+ )q݋K?CO\<# ̤xeR*|* ouD!')i'_ f9%'lfƨ.>T]Q߽'!"eŸ`H5HsVF5'c$Cqn/TFoN=g`T÷D`x_>`?d ɥ-նTqQ` q9c蒀_RIp@|T>GbBڵWrOq<yQM5筩6!Τ; K+x9< | T|fک;6,cD| QInׁ͈ZCUpd2?ȫ\x$1/;8\'sʍ,^Q;O9Pua~",rq KeSuJq?YRO]SQJ(Fz8a]C IU:u7Bɣ^eU=h9!@_zPtl,YWzS?aoud _@L0޾=3X]Mzv(2H*|#gqy*|p+ nqMoE l+UR!>Łrd鐦M;uݩzANq\/<O #Th朗4!k5*Q!?"f|EWqkCіP7shȏ1n_&](`:Rg"{*bE,FMM;HR5LHO- H$xª>U3T)GY0x)CFg/ Ġ5n+ 2q ɜAp+9ǁLU8dc}7K=k^jxn m',5%w|Dxʞ"۪vζu (Cqetl9\.vxhO}M ~hvDIMoo:.xXF EdLH тx솮 ;h[ļ%rҢGJU/Mi &ڕt!]3P ]s,]HI5ƒ{+,7YC/$W4.@uc2I䆡UtuyoߚxȪhJV&{g{h!w Tz)й-Ԥܩ _ {k>;uG |Å+UUP舐Dhv0V_Ȥq?9 6?M|pۤ?Cď*_sJ-[P)~|]=td}{ISC::x2"Ǒ:7ٞ*VcO^S6GqQɐno co՜ E׻nz"We\3ߚtEr`NTMSҴL@7h 9>cx>'\wb:oSI"-H=-P;dH 3Q2dbɣ8zO9IjhMzvJoUn9#`A+rkGEE;.fHηgOfVs3QME)哧qh*<#+m t%GU'SWTa]a(U[ŀРI껶v}iN9"ހJ귎pĘh}OD =Xˍ ]-b Yf᤺]yHI~%M.6r@"k42Xh41;!o se.@.?Qkt}-`=a8Yo~Szt: ZvNU[xjJw#XXS *kwE z×8 B7wtIt[`17Q)/Pޔ3Eg(w^, |FN=P9> CAt4m,IpW:xF* 7gO``! GpB{ WZY lV:Z9Z "騷]OzmŔ(>$S<ۂ 2.|D<<hN&=./̕/4R%zZAZ"q=7mw?ok~A2O|+7*x^DSj[lMQ%glhWs)"NVCW{WX#4&荄1G tw4k0TDSWflb8]bNXB-j^\uVGe$ߨț? /OLbzOJI4kKP~%…l/siY^TI"16j/קHߺgKu23TBzqv]b^^q}$*_,H}Ǔ[ytX1MR`ogSM>oQ9W /D,N;^+VjuC;'@k[ y:OQ? fh3{Lax4'XD]h=8PwkzGOTM/J֚ӓk{ThD,.>_BBUQU{b<5)mU)C0dx}dJpQ?5YBfqT:۳SeiOc-1uݧb8rzT*w7u:hKU&>PR>܌,j'ֳ9"ހ7Z~[҄<]:^x}86~E,%罉fh M\j<|2{.b x;+%ۜx%[\m5(a+c@["mEv+~>77CUKy-pF9 mMUQ 㺗m̂%XG4ns4PÏ)}&ͳ6ow$2ӌvVCJ;<9{ MU.=Fxod.$h{&{H%]'mlj;>*MӠRP|H(H~9,J;TQLI. =pd%[]"\d#*H=͍GR:PW~E(I^a m, \ze0ISbX=Fe,N;ҺuiϞ;BhlԾuf Trԋ&h{ `([GB.TRJ-Z$})~ib_ز3Vn^)xG}w|{3_9W)[ Lr{YN[+--wPD)ȧtn+D#oXṽ=>uʺX*)=` dA  XPKFM8: NXNhyxVaߢh~IԱ7Dr^A")t5%_=5ޅS-3nnY9 @ܻZKoB4$-dc[{s)fbZl0 vtE@Zt/.9l1/t;?P-פ[KiNeE\3׀SC<[prmВSYH h M*a]Y :a}Е-S>F9?`ZCO܇Y΃SSCejd"cܱ$q(*bQCJjL:UD! >0 7\$B7cq[EX?XEs1L} zF2"y]^5! uͨq,AXfhe7GEQ-x+jфCkEy+K j$E&j5&#˓*Y>~}wCYke2Ez$9؁BX}#9`$I0Kd}[nR~L'2?,O{H =}k;k:/gjO]P1k*[,Whq"A%Gjbg!Z-wл[)T띩ȡ8 P뷨FLg s]q NFm>#Y$OَcTmGѮ"Vh2aZ-΃A I䪳"afTʾkikFBL5߇d= f78MMNe夏RQGW d3+EZ%P[*T@`T!džu[0z!؊~G骏t:$[͏_EO뎿wa ]}(1)Qb 6`OQO 0?Qw٩?'"{|VX$Y|-G|QY''AGd-y|GG|Z}q:o> v#YeQcgyxͳSy%|WLoǦ s<)$|8͚D(g5D(ؙ,w%M<#4C- {騾$PX$+z(q"ÚbXYʭ8ufǏ"FvQI*ѻ(i0hCk­x䕋I0SRˊTBu"js[/aJ; EB*Rܵ(/Σے) .һ,zrlYfJIh%i5ҘJF7"O%C!]}E*۸_qm~$wF.bG*uClduMkL}k$*ASb]4_jybO)!j~&\gX_sƩävJH3٦ԵDQ넛s!R YtKRd+!_p45,pO) w0.;,GØBS5xX8<0g+#0|amg>t`=#R 3qxPWkFYjCL5$&&n #P:>Ba @qh,9˥(2א}c^O@[>טaWߗ|i_MסfoNH&P-eFV"3)[dW8#)1kܵlFVɰ4 i5Ot͐^deϴwyW3SU_z]ޖ:/gOD3n0Mk*[hYݱJJH)RUD'ᘘ꾂rT_umu'X0tߢoY|y˅>Sy%MܤW&Lգ.t@$2dZ)V6E|R ls ɀ;F/c5˟(}j,~a,H,dVZ5:/,x=$p ~pMgR)Vga] Ay _iFTyK^7yĉѩ| վ+?uJ(w*P zߍk {om#*T0\h'֥_^+WtZ.9ei.,h FZL) DRkk{VyP,ԎgoP u8!:2zFW =IO?ۦ G. da9^x]Զw %؃ M"#nqrd´NW{}-~/M_̡YE\'?pZ˜k=-h85LB 55QzyÄᄚx@ *n D2}$}|f)0nuh!)c̢iRB \s1QϷ,fx )Q%hQ'ׂv0Q~%́+m}N.ci3G""=RMIY^"16CTNRs 0j鶺"c|CXXU6^)YvGOo2%I"z})ӣU[nNATtzt@×L8g97izғ8u)lb-4n*$p2gi Q_;k{0\;!%ten:2065ŖUUw_~@ʍ!g.RYR?*ז&Jy;-R<::u3ЊV]e EX'"f4ܰ>7E3.\MI3ӤAt!rZ(-JmCiW.)Ijk՗Tk9 8 ,ro9lZM%rэ 1rggB~,c ѾZ}e-ZsCf JNvwryr c}?*G;NGT jO`#wMվ=E9$5=lAZ/XfA MbYN`Fܚ &aʑlmSZA\32z3ʐnKfB?\KzCvS ¹p5UlB5bҩ*`_8t2\E:6|q1HsKA( \s|1KOxa#YrȞ1`QAYuBcdݞW*A,Ć@ $glP3?)U {X+!QjQD'~{H2,J1Ì&>)`AL[L936zj͍䔤4HMd̆Tͥ`,Ә;#K^rcm>On>8i(YHXꁅyI8<=ǽ\RC9F)~CTTL.@ԅ݀ՁO>oTMͪ7~dn'X |:c8EA^ŻZc-82gI +$uOAEQFRoFZ'3=ʒ4?\W]Mc^^ >8}ޥ{!ոVX7hNrڔf ƐnՐmԅH&6Ri釦KsfgoN\/ギٝ*8YVCg"uu֋$5&6~UcMHt 0K=5 ay#؃-c>@p$HWropEn+c׏݃,pi|eEI)!v!F|֯kX1so5KΡwQRClXVR3d=K+U5"'B"bLapO0I:&&X2?T;+lSȤ' `f_9;R讯~(ذP0:h)ؕjqW?>@ s%Eh s|Sp@f꧸wXv?z>K|\#} ?>y?L{>Lo?15Hi?Vw<+O! s>R?v?sv3MMiy/I<fnٮ[TVM62xV؟!OGS>xUTb$[1O wǞ9P ǎH80|"nZeۈi+#2KZKCw{uc_> ]-)=ꃴԄPB;iRSYbm _ ~kwߺ5si[~o?~K7P/KuXpp'D/Rt0 D]L<펵gT&q,F/w8Ƒ̂Ct^$`0)Xѐ4јAd*OqԠLZ]5[k2T:"Cϙ@z9f f8P!dm3nVC᭗-]K.uK]ДKS7l9׼.}(1YLA:cƨdɛ5g-  =>g* 1Sh>2SV!O_Ox~ QfH!ov|IFsPFZKḗxa!`&atPR}]D4-Xv7wu-Mzga)#hߎ%@=X6#RJeCI6JWBE݈.*} =Tx3!xnyv.P 1$p(3eИkQ O0`USß$}:xj29" S,c &s >`4r|l䠬hj7Ԉi I6lj;JM-Zﺌ0*13)_pbN 8,Vz(P~iE%|Ž%-nQ!YUjHg3%TI 0>[J^[Jz΄㗎u ]ؕ"x~ȊmV b5XR48L Ѯ,W۠:%D_*к^j6ZdaѾg=71%WVq߶j.ݼo`O<$U705Jt-Ty[W᷸n=&̗O)9ζ1~cB,$C cntuka-: )L@,E "q<4,}ù7xAKKٗfV86r^!Dm%#oD==T<[]TΤd'k LdR=&L])0('jhqb\TJY^X2XKUv똰" 6it+Q(& NFtPɅ6 *?J֜V7fP)qjΊZ4b!2NO4 Li9vqڧZM눾Ahh(!XmZڤa +w6ʀբW_cq0)I3WRpv>0BzwLoCú&̀& Y5Ι}gZQZTn: %"ЕX΁T8.4@# o4T/ϔ}i98MҲT}i-r|:XAI8:*S]-CO`<"/7:! YeȮ #}>|ePf]#:i%A+Mz1DDz\x-:!`Ƀ4D鶺1TX?R㵙eod]Fꚟ˳/ez,jD^wQd)_3hU}zy15Dw_ߪ,uf- bDTM/LDjv<**BJxD?Hν섿 9 u-{QVAS7eGbVEԏ wD :@_N zOZG֘I)&r*kRi)!. o*nYt<İINPZ*jn.j;Zrp9h=7lRWMZ_%:)?#~F g!G٢|4jɷnWrhWv׍4ҳcc'|-WoHjF>Noʿ곸}WUM]׷75#řtޙzc 1ar޲>/;AE/WsJǚVDwjZ%·Ȳ4.iжQ.Uz}Ì&EZ:܊>L(-XB.J'Y`GÏR Gs 2TwV"#c3w?|\qlx; t.- @WEGHk9 JR)P2p^{U/+yVasL(G=Ѩ[ȇ$q()1FFCzDd2bRE3I,4[%=gP IEL#i!.QU쮬ޣL yzvH[,UɗK7^YWdER׶&.d.*ugO&5Vb )xk\ ErZ9r]v4+ ޕUYtPQ4E([벩,%jo r*=pzaaZ ćLW5>C2"ήOzQTss9 я~uti鹶;FYuŸ~,v*#gǮ`=Ba:=GRAၵ3TN(-< /eO~87-WB*td\m,T`-K'jF'}V k*kH&uD0OVPdj~VJF7*Qxȏ=5Cu{T#f+s-oY}3zDĜy.dSϺeJrddc)K|DC9_j,ښՉ+  !1y 9~o?܌K跊9(teR,Q`K ́"emuk{]ixݸ[Cb tܰVm \kF|1 (hc8䣽Lr^PM^f08^O5jsb|?}!+_ K&.vE(;~ڐC U!\^UhL<%BBSBBBpk]xOIZl5-+Ɠ&!W@#,u;%~X*0zk1Eڶ@-Y3Wy a k4z'ȉMy i1i$X%İZt 8隚]TytHGW&د}{eu3}}M _i`TNR߀ǏW)Y\d۶:Էr3NuuieWGa|  _yX/?{~影| !f)r'TPL?]6OH{{di9I}LioK1pa[_!n}NMiD0tiP7EV̀/g3GHL+&!љ:whEͨ}b}p-]F۵&\])d15]y ٶP[z|h0 K.5{c0 os#Qi dz,( O4'ڶ7:qܸF7vOf ͞ 59o.%MSQb&q'`X;4 8GoWo 犱\T ]@IK&,A@-:֏(İ_k7%UY/]K Ux {nh\ɯe2$ úy΀T ڝJsx%K[b?F2.Ï *i8X 0 Ʀˆy"x{Jl=}?hVD+cճMdaa8.w'?"49uygx_Zկ3zPmRvQ7@;!iX`f.!LQwȲIx!)ey:t>v6" \|$ڒ[s!,=:|"E0eǺ6ÌDT`&(P˯.<6TC=$$My"~MNv_!!6[e_{JE}poŌW+ay8"%+4@ MhJ"kkƪD[%(hf' X|l}Uw )QcJׅy$oiJ;h;w 9q5R~kn4UᚢP%rYCf\C3SoZܤIXuNB)w fҨ{ + `ʲ\n4'LSvk!mN1E2vls5Ooo,UVC &;u_s֩N Z.)kpm^l\S">JgDE"R֛) >Wz6d Fᝀ<&C hz({8bh,|C&"I/9ѫ*癘]{3_ TA{cId4xo*+5_$˨p$ߠ݋]1 -wk! seW^;ҋQͅo侰iS_8`@:LPM]?xc+D^`H">8|1OAմat e RiפFq5{0CcUrgA6.)gIj~q$ik'ۢu}hg3 N8E/%Z|UK B*)7vaXc0ϥ9"/{U~wΡx;UX|GXR@v=W :Ǔ2 *G%))SO*rě<5(@H⮷/ر^$k]BRM lb2JWWq +\YA@5O'FI*`!%*%/s SXf񀪖;pd48pH'_3Ep .ryr$ Fb?5;`4wNv_S~yWw)]Uw}_ȼ3 vQ!(2aYC#tHjݼ~Sc|Eܙ~=jpђ||FoЩ;n Z eԭA p7&0 IƌW _+ z:~rL|f%2/Iw_B9aIf+1nq(LӺv5 8] -s ˞_a1#)4ysӗ:4CyVl?,m%֛ZBR8ALX&zbTME!|՘$EݑV6J .ha:q-q>3Ζ, ̤ p$ùSll!,knb(?2wE2n@1*a*6KWHwՇ0קXȝooAϊ~^@xc sJ]mq(0biVBx_nn]-ayOXu5Ř!I`Ib.uS %pXZcoi>Rа bN3U90eFdP|yR"e&;I#3ͮS ^qיּ>Ɖ%,?bIѨS-*+CIMX xfSΩNQ4eu]їР_@L5KDe̚@ Q |EչWzg>$36tzVsjZe|Z68KIY)_J 뚴K 'HtAEݦVH]*ɄZI_% դ{%2Ej'8懁T.R›`ƢJx=rw٧8\ A"Ɨ@T`8!^O(IGCaP)|TPoKp $R/J镅G/vrИị!$BNľ9U}̗ Y p6s5WtۖngkNv9YN@XV fgeY+ 86쥔݇'/A>,yфטl]#/ cUu$pF';?YK^qT:ѨKb|#hREWӉp=xZ ~4{1AQYlYQUE(=ѩ.n1:t%˲zT*kKEA9u24:U1ic Mk.+A Uym)5]V;팄7GY8HI.˙@Z b._ YNjk՗Tk9 Dˁp|u3O@Za7<~|X>,v }%[`WXc0giY n fCӵq8ryr} "t֘an\K>^fuX[ojp$޿{I<ј'eh$O&**,C Rlh&餠N:$7"0lȫރ2j,w+Ջ(&w Ыܺ4I lx\O& ^iրBhXq'z"a[M/R7 PA]s7ŜFtBr\MZorz=Rfl-TKJF\; *>n(*aU6cg"GT̑RoȄrXPYDJT|,w^RT17{# B9CC$>Q9s#JA x ,TYax-FIlr .-wk!aeI+΁m.|P!M#>ہu0ћC)7u-5|_&VUh7 2{`Fˬd @*Yeh"Z _"~h܇j>$?O8$qzI[9Me2:sNDz,(G/M]chC8BH6T^ЧT9kRCcںVj?:%pPǁVkX^bqKk&}Ø=p,~B;T&Ƽ-_uu:k &k*kr)Os m~"sXwKg7dZ2-U0^ʈΚ躑 ꈣV0C: V;Q85 25V8 f'fI:a!ܛfbkܗSBMÈk_Ʀ^'d7G #Sl;]KZ6v4ztDugu4F(4K2.16֓mG^daicD9xUa\Tc/Mbd 辧eGtw&uBC?& cD4br~R`zxɂ1v ?lV޷X Kg*}3E LO53it`zKa7>dx7gtM4U<33gYȵ5߱Wpq!yX:MQ5 '/X.(AU-dil9۱:m-r~OTQ@+Luv$#ӣ⮇NRٞm:Ljv$ّٯq5A[L"k7[LQtvD2"<޻h)/sukyNː?z7ٿxڞ u|}D9Uخ lA>+|nY9b:%+eܷWÏٵc־|HmO5ZpzډaGg Df 3rN[B S5+WŷZ_&8qiX = v'2csDp&S:99w&ոܢz2ڌ4fu?70h jaqx*^6@Lx_.Q5ޞ=H/HuGSzW6V2Eb{=vלәxF( wMMs{c`7:gj^"륇7VL[.:Q߇:͏Pq|ŁߨqKOUkIKĐѷX 4&pV% bw w8 \^*f|xC;R%tc{ygjOG/֝*/67o: me3#c֏A1z')T!9_?lJ?My8t:y,WiDS5 =_Hf5dk-/@M~ HxM3mJK`WЙ줘a4+K\p ;_CelVMj`0RJd1W>¼\&W Hi=jhaR6!}N#Dt;PuTCQvw׎f!r#sWG?%!$떸\tCO:K^{N>(@\/Uj'yJ0R1rf R)fЇ9xDݚ 5i^|hxQsy0_xoWLju.t$np +yXZAx`\m!0W|şpb}'yjy.o-K,O ;;<ͽh>' C՘XVڶyj})qYS,ɯ;I>.KOz@l۔Xj m(]~{% 5y3Ӻx Uwe.2~h4%'" _8q2> nZ61H9QVcOT?΂w sp_{GR ())疝}gyƻ^jbL%>(r($|*L2z?Xg7Qu > %uw1FKG,˃~jK;~^G^}[{5]ޙn+?/>x4KǙ IyK4~ t g ~{sxDe۫Fis]Ǥ>hM0qv-xy` o+?f;7N(fn)9.\PY۠ZCkVi.s$In:E_G!o YSNBr)&E=SzHbznM{k!PZ]v< jO*;Ev4o>!{\'{|+nUr 5v=Ip~AkLD\R 2cnj.=k\ =K@XT6kZK!\%aZvay5j~ZTT]2"kkҰzܳNv˿uMܬdrR&vQ5¸.q+NW[`.C.~/vN9#%kI(ՆMػ%ǚ޳@'Kگ< sPϭ~&)bP~>0?(T9S5eT4銔͝Ҭ4@0 i6(m!\PDMRSbS dXXl ƕgF*|On3Ǟ0+4EZpl|-7 $dFyÄC!Tddwj%/eesꪵPqt ;FqߏYB@jnNU6עC /08%7ungt_W FlmQQ5Hw#1eit𓘹pE, >hj@B]@2,Z=72GR:N˄jgerLWPȥ{Vgst %a ^Dh%DӮb7guENv=o7UdI^esRe#$+IbQk\[N#jC4v7Vrq=h5ߜh/<(J1&&6J߳Rsg@EWǺ! [ew@uA7O: c)|$c"n?RMNE0]4abK(*c@t>6չUj"9 ;iJ߀zz,_@3n@CE0>VBN WM^ PywCcoĖTZM'JQhTvGRmNƧef2va^%.w{5׼[\A1'M3<%cKaS yn,H|!<. : Ch}*0TCZ|HwҜo[hw괶s[%!EyntoY~0cGpW $o !j5t6_5/qH/~b<},KJ#ƆN0NPᒝ? ɲҞ.6FMtWgN)kyxkCS>IU-*sIo@&gAgl+NZ2b0E5ayM,?RN_'òDTǿ$C fxqG샿zd 1qBvG-y H PƉnHܔURO&ZY&Bǩ9t4' G%4g\A5<Ƃf-\vnQMƗ*F4@ f{*U3ww{7!'QLt%זӈڠ UEr嶷V&f Y`) DHzi{ t@ui‚mXo SH |&G_-7@&3O˾(uh_JdBƭoI[q<4{@ڊ3MK~ Z?麺7| V]t)()7)*H"L j_H#^Ԣ.ۀ(|6Y|A z0xb%t. 2Xz-$J4t2YRY&)RA|*J }܎Ϟ7'rN.]D~v}M ?bv"=Ĩ'$\9IYO $"(P}ST*Nx~u!2-@M 7d,#,x `ӴrUF:͒h8)u Q/yETTq؎4 `jvXkS F'F"H,fpoa)zVؤ20~5 0 pPq54jJ]GISy9Z좰>as ,)xq_[ 1NcNAĘ_s.yhE)Wb/lIrԕg@L2KUNKUֵJem6:BIw1ߤS;4*9bD*%&5Gp{~aA"wK-iFJƍj{8SW(l"sg!Q.X/|r^Rq i lc.ߪ+藖 #LFu^OЖBhEŊ<d- :b}}iŀ株9brO򃱿>hWFեKp4Ȝϓᝲ$Hdc%v[*n&K^R8˸]\uyuի~8q ڎmANO6,b-ДeSHGxjY Uœ 3 G>kKƀ݋x 2. -{tJ>7 4SSQSe|kB]PT(W߫C DIjj-@ۭ'o q;н3^Yu4zx(юfE_vXjNuY*|̖=ZP T<4Ի*ԫ:TTJ"'b-Uoz7zO' 0ߪ^Z }i۾7505Ur] jY"GsVA q-/%n(I߲ɜRIc6ܣ3Lҝ-h,-L#[lySn|4!Re{4 Rڭ4jqs28R9\r>r9*X 'ⶆT/Wo="b,Y+D*]:#Ůr2?;<|`:{tsP}`"/E'KE j'ץe+yQ{0Ͽ"t"nEj3nQD:4[ Zi!/u P\E!k rT(V°Rlp2 )LAyx{ttaZj AZQ#QkZ^* 0v+/ ;eq5h* yq4Q*4Mjӟ\L0GޓI*}ciK3Γn7z 8>Ey_ 6 !Ez05c{ WoD?ûwy>exR:_(40ӮK-fxK&mZ9rE4N3b\cd0xaMԞ+ʯ*;kH~C?a!vmE~0O M LoD NU'4Q;Kņ$wR q$B >5p[.ewB,o3>);5rAcG{><&GLVܧ!-,CV);tUx6rXuK5dj,L7vTio0Dъ,NM$6 aRt'~ЕCNfn)WWSZV }m6:s&ur/(AB3qP9)2^(d>v債O\/X|-4\J7ˮ1>EoB}l"sgOMoÓH•29\M\ט~] [LX809s-mO\hKaaQ\d c%q I+kj)ם+e 5Ú;>r}іb&qX |DPy&`/Pj&ySIYeS"wF7R1g"՜pX\=b:W\GT΁w5P4$vΠVx$~PS!ˍonj8v4DPg k 3 e 'S*b.=4FiJzFRl=$)6\-R\ ^aa˘..ADvD$0.eЮišnPϪ9[han|q;q~E+_jx&}<4_k ZOaJɶ1x(t=ɂgpD_ڹz'Zׯ7` OgiBuuƻ-Yt(<\)mCGʧ/m>[f)?RdR6ޣvBP#Wav]O#\'< Nš=}dz@UJ_%?UQ˽kX/#k-n۠Y4fNfr6Uf֝kȘRQ#RlC.O7etP:cdN,mSu6H_̎d߁PW$z#e$WjeOB݄[H\ٴ80^?N ]Qdy%ʢi(gaDq&j3sBHu*Uq8UC 6Lx]=f _((0xљfDhg%tgj lc KF·s#\lb??HgZVJ2) EbՈM[B6C8\31熯0_ JRJ,a4V~,v0 ' Ao:t&P*Y};|o@=b{E&V A̷&{q3pClUl7&EAN+|h[.!kB|q]5&cݵelKt`Q%nv묺iW=eΕP^?Wz,&:-%>Su7i wIArW,_RӔ,]9}d.VG:5X:>w;_47U|P@': 4Th !S`ъ0\eH' *:٭]S yS.oٔ` H 6KzL8le]92η0c,I !+N=I]jJo%,{W<@4&ϕVij3Y>뒛&==kܒew46UBP Et~ CzOaxg)+̲`ϢƓ4t&V#bޏ;_#m nYm+^gD[x>ӯqZApxFY\M;eT0BYLdY)UNj){)ߤ`-w"c$zV4PyKaf2";g?4lr1ںc" AI+&89jUub%hb:We??]&0xIKuZ64-myG7y&T{e,]wN(H:-]7G9]]4uTg*tM;Mɡ/&"T5ѤF#ZWsh1psIUaˆ !vi؇2Qxғk^)+F'%ִu'E{M2IKi D^-E[rM?$GIk=QD|-~J,9HGK0QSVGWJlDLJ+T.c`V ɴq籺(@ 3hKze/2iGjuR2?J;X[txђChc-]6y( %C%ݴ6)\r4(81QTUy:9k M6b`&m֋km3$F|"4C#%Y]A:"&xv]C@aƺރ|Y3%$Qc]NzZ%r6"AWq"ºtx| mQmda*oOc&^ZN3R%MRoLnrw3&*dž$5= 2%oPj=}EwMVִ[S|{ M֚wF=ksq c#|1[qX\=b:W\CL|] ׼ )Uk pu#qcToJ_{xH/^)AHq8K4?EvKczF֛=Nq?Ҳk3m>lFXG~?ZVdscw146#yO?Fk!mbL;OndF$-*A J1((b!,+a鴲n:#*ex 8Hv!'!ů R$rXq$3Y1뤦^ORR|P)5S7=,o˺C6(Bzҩk9) $#RGx,)fŚٍx$XV[] ʣvW̮20seSsӵ6 \v|+1H=N|ſEQ< ijmI:r!\~ PQP%Bmtqbe%IC_En ZWDM2!1PDMNDzib8.^B@ucsGmIy,W:u-)Sml{,A_R*&ɤ]U \^Rv[tM,#Гre:B6eUCڐlDQՆu0zTkf@^?N3wz#NE@3t@*̔J:^ !;PLTդ9Am 88u awG}E( |jʛ:k_ZV.T1lുB;k$ t[Ou!J M>Fh!J-/mڣ-O@ ;LUi:3v;vj`}|ߠBsS6T@ .9F>zʢ3^4*h>j6|\S^#q%=hqDHJ|koT2tiם֖‡VbYXKI)GUr* >2 A3ch`^ VyPU5LrNRoR $^ S_]g 5xy-cUЛGHdyMGi5]P$tį(psJSlV~{S׺Q3MhIJ?a`cBz:-exb Z5R4 cym>!Mu; W_Q}MIo@ zEnf) vAd/HxX[Rb]BsJ5@=go5P+wwUTM d<~*XRJm3xurT=.}7}Mg_8pBJݿf5cg0~>-ַD~tUh"5IΥtFtYmCi*>)FjeeAX0y(H)KйچZm&QkT*&! 86SѨ,)I %I:֡HkbHl8Q~-=>HSQ]*h8{jW=(J!@n H/Ds%z_|7'X+ d^$:^*RxIuMՠ ALWzӶvs%˗fZxcj$Z/1}7٨H{*uwd!R>(669*B MZ~I>hI=nA5zt,Ǧ`}\{{Kv7uFI_]>x< !R|΄b!@}\sbjhCOP@ "!79/m%ŹrG 3jA3w BÖrDC B %+ʷHŌv#kU@+ K JO.p4QcH[+^D/,}b^gZ x%_PDSω˵R"!bޒ}/knG/ʻo`^6j9 X)lqht5J8A\FJr0K,(t]7Fȇ=TSoU50QD*)i:OɺYYF6hpj6*(9y >DehmzEyEeqMIC/v=BWE:PuX$arS/V,2eIC*r,05~Ԣ!Ph^j :J'8o3ZNe!i.#wPmA_{Rl JY 2NJY2Pi2L3k'B;oHRUПXA?{$q2qEԗsyY5)B*W/Lak_,`sΊIkS)&PaZ韒s5gk&_VN.ĦN鑢"8P_FT⊝sJA4С|wEDX2MCbK"dҭ=9ؔp8җ췪)C-MEA!JBkp~)y!2[vo*.T/s4q ot?~=TNl_1܁k>d!v#BM,]KgҶ)gM}%/ϬEQ ϳ1j@IkIw[h)z#Q)%LQh"/̩cȶD*.(ɾ3"T S rNxӨGݒ4FyN']P l=d[{#)ćH}hhigN^ޓI/-g X8F@7пTt+kTH -Z#U!*9wM"DUi bɄhZ?zNLQӜO=ܔlrr<ϭ+vauN:?ߑLK6)_xBq(PהPBVrx*iրN3<+͗?ʎH䠩t= &Ry>L)ܾK]0gSL>أ~P>O)BȴRtR qeҧH*'q퉜b?22n‹ 4n5ר*JVyBsgpQ!9:;+#YLL#a=2L'q)2kv]ˇ+l V-xXAM ]eK*&U 73Mb1\j&y(/uԚ_7` 8~ /w8pTK$%6wiu!)CvHDH0Ld*-#Eb\K<drnrX5B]BQ 09xҵVwi4x]|~˸J+5-C$..w6jP`2.C"^D[ZW9G-9@ZSe(ΜE>i.>=UIlݵ,3'gelP0\4m|N[i}cWHcAEWt֐XMGLS=rv2,`DZfVz45tMN^guK׷c+O됡qy K ?jE"4}BOy]a:akbOyr鉔)de0Tdge]HO͉o]u;Uw2i:p6 [~5f+)k+ҀKɠA~GOhZg2%$Yd)ע ՐޠF-{ jBue.[CUo`Վ9{o|dqMFxup`Ud\")U-_@$p  z7JͷvLb 7h9dXV>-< ySuI s1(Y) H{*'h<pM^Tr^"Y{NŒ&ЛW֕A-Wj\f.vi'}O >Ud2P.s|AF UTZCAF[-3,:t,͕UEqTc͗CQD SůO^Wm^SHV%5!ZsW<ƶLXHxYv]&\03CjewnPbE9؈ !>ύ>l ±VQ]cf ˗D-$TVoة[̻l@ʑ)4>"oRpNDSdQu?ۢxvEY='w9#;n?qN"{Gu^ 4Pw prhAQtgM!&RmSE`n+wkYyY~-KeD:l>7ִ, s D[fs[7v$r&<:[S(8 v$ 4~{(o.5gy8T%<;Jd_Ē_.?`'<Ɨ:wj/Q_x?4>An/# ,iUGb<UfVj ;s_^Iߎ#s1)'N? 㖼ʨr3 ` R) i6B~׻.}SŜ^>%"±͌]5Fz~j~UۂcDC)/ј&ީ="fw3M$e+1wF]7i.NMUrr}'<6Fn\dQT)tU[K|kžI;/2w~s *3IqШfUԆ=˹JWN >@𢗬CyE ^2⵺Q/@d~f\bFfxEכ)eޓ+_a[6?roSX`c$%kR(_h˞&")k3TxLQ@fi B5H=ʪإ*/:FK腢qmE eU ^rn9]o)WvÿUOBWdE_Wd?̬F89n\tx+!~.Hydi'_ϔޅg$4o{{xMR9DGӑ+Uqͱ{k?fv+ `:І~ e`@!Vx#H/AfIM>(p4` ^Qe "ޖp(z+IY7uoDq\q ڛ߂j[z-vr>~`uV2y%|z{!98–ћm")TeNv̯5L2V"E_'>\s%TL/<]׽lODf!qUn<,;o,q $3@st_FO,)$:ZJ^`ɖ+M|O!a] ^Jxǵh;%g{| y+mIinjvX-h{4AlFzS3Y;{\xTjH&c3K|7Ƶ[@d)\僯rz1c~_-+ܾt-qV31dW1c]q0q@NղMb\ w KOSk\/<O\eؗ{)oСװ@Tč;(8.c:Fh8P}|-bV0؝ڣ卄z6JIQJvh83I|DܤR,bb=n#Ty~.h:)yķ_#e\]aZqZwHj%́#-vo,^E`m{/*Rʸ=،j+"n8\(1Oy%r 9+LČZh Wo, sc W_ 1D|sQߦO.c")Y")P{h#EݴM,pbx;50Vl`ͪ a'3Ơ{i]cU_Xc`(fW#o`:LgwA:o7|+![ V?p_ixoJw-ʪ'fmJNPH.Ÿڃt P- .+\b@F5] 8Q ڬ7 [MzUƵ/[ysh ^fI U<ܴ O7 YCf3-pMKex*k#js 6YǛF>A[n_ }t1U-PBW &' ck׫ O>q |+l;ŭ{:W?ǤPs p5ֹȩD+;|̄3@l )?)!q걬YE2#hǽ4ܓ[`l7ny!m4Pq=r/&P@b84ؘA0gPzvb*9ExRLb[Fɉ.cJy 1$Ɋ=j[컾8 Ev[[* x#Mk׶Rzs*妮`[ 5`H[E|é~O?8EEFqPȏ;7\WHTspJF7,$ (fP=(5vv.(Ai:{}hg9nfܰSΓnme|9wPmσq5W䳏si]DT⃰W:#ޒ+8c jĵA]#JI5R%9RI*m)݂]FRS* ȹh5lO7b낯F0G#c8U㼥m,P?KMUQ)Sz3~INj$ M@*޳@]&21.U Y])v$JIVR2p͑!Ddu,)}k.zk.Z4 +K!~RCߣs ܷ$Glk Tؿ%i.Tj:~]Np%ɍSKa)[CuqZ\˚^lJ<5B1Ѳ!ǧfhryzb ƍhZniͼ|c>]kϓ:VXj1i%@(SuJkq?>j9'pkD}s95IC||&o*tmפgO`)* hTChh|]t&g 견^k[%!4M㼧!ZoϞJJ`LR sm>yښd^g׽n%4=]pqg3t/ 5bkJ9([lTls{wmu}N킜qnހ\1>h}x_hrQaLݢƯF Ue[HDrr솁hUh=q`f[{j)qfϱ&Q읮ѻ4ح&1$$7}Ҹbauf=V !ƅhdtLJrLj83GH׌*] 3jdY#`GmDMt]UXFL0b֜_x6810K+sU+7zǩ'6Laq2x1UL$ ߧ}<)#NHsrx@pS'zDO_"[;,Oj ?(7\>۸tZ?tg$v z_şgF-U6\SSq[gr,4_-LDj愥Z I% `r1 9-]y'?5-7j+x[:,m~kƈGlC!}9\?}k$ cOO45'vkI=qqQuM_MknlDG̀y[ce5z#}t!~HC]=nI 8QaaeƪQu^7ҝv=^-#Qݥ"]n,DN4,Ppi4XzWUDa{,# 7[6UKfrHg qp3L(.T0gZ7|2PJj,_ (y]I&k- /!ؠfIA֕}L ePuUeڂ&Y ?KeUVOu(uIVkՐL'3=Q{Y>>\`!*O[EH*tHq_?[w,lHr|":Z^C˅4r>;DX{.؇Re dqjiIMoS"΅ˡ'xgC8q>OcyWQe 0S:+=|&SgRxӎ1K.î5LT 䔐j>9@S7nVOT38L:'] ")#r])3*{t 8EDNx]ڊ#7xJBVV[k첍|C@62 O9՘p*x^ c *#n= ))=/aء}lqͺ\.J@f?]^O>}쭌ծu !ޝ3Ɖ( }4Y1QJT+WXt1OxPԚu=J]/vzI'1Dشܩ4cn(ޔ&byF{jghѿUSelڨJ:ʉDrc[kb$:SQF^uGeoHp}>7)ľ $12m'diJen)èrWUo±{Pw3>"txVWt '/ЫV[<hbL T:q]p,HF%^=#Pݺ4yIt7n3 3{0i pMe8׿3ud `vcYM|hmZK&Q.ZbT cC_Ȫl҇$+^Tl-KJa \vlJ6Tȷ͸qE-f%+ЃIU=Uxƌ/'R>񑏏|FQR۴;{U.Vi= |x'ધA\d:+:=k.0c݆U<<$$ A6 rjy +Rb9+Bu(m JDB=R:}jS@?26DLq:Zb5q̀I IwMµ[4dqԌIf9K}w򍉏]L5v ',juUYfL,m z@qΣm?#~v̤dMO+l:tG٣^D|Sh( 2ijޅ;&i uݬNy+5fK֛7 D=?:7]cq`=()3nPfqV*0M+tKe|E$Q' u-Bk",[Vd{m-薵f;#.T͋b+ב_╏yv܆Ez=bH'jB]bޜἓ񊴣*šފsN=8'|=vkV4WnX:XG_7y.qS)3vB&<\-V^ QGH[Uoy)K9)[TG<,[>9hc=.2yzd5;uZҾ)~t/6Y@4S0I { ,Gֺ iH_| 8l>X ]uݤzߑe PO{P@ָ؞.~zޞl% Qs3: T4;%9Yi`C|z-`tS=;k/`=Ou]9컢b̫(e}k6;!LdguV0jZt.BM\5C/ǕC1ȗSe%<5{ J䋾@Uc Ncuǧ^0+5/+J8]P~(}YA1Yce(C)(TnL? hK~fѴSG{y0&oF;I3(/4І37; 0j2yHMZ韠]%'Im2c?3Py3z^u[WHn]t+0 lva.9y:.) M1'Y%|D=_ӈxu c~X9Jʌ-=.9݀`:ho9B"O_QDCCٯ%Wܻ井9W y ܪiT"Npt 3Sꅸ\k-'zU'~.\| K"8ޘ'Lv=`uK)OwP4&xRߜ[JqXsƙ8G,_Qh9G\~_ uˆ8j!. M5JQc1&4_x*+[![<[UoVϹ|B"?O t7~7of~ҭXht&^zkxrW_FfE*PH'Z4&[JHmz^/H9nZ7 ꐣDŠGv7H09fIcr/%G=sg`Xb 8:S w+.!⭦eHÖUrH0n?hT̺A"KX1j?ԪۡJb-Z-yDPB \P#ƒ@˃*Ċgs`&mBv"OyG5UvkR~"T-RձUZYly RD=eI_f {H)0U1qz|o;y'o4tkR@Ah!K{HD֍!*?_C JZOب on? 4ڣdZ'6Gwj@5#pHK4ջ4,c@sC A$VjP@rq9+W%R?jZ)vWg AD j.8~s7!n m'h;]E GZW ]( "ٵlکVz5jT~Z%uc,9QӢ\5JK3_YȵlxiR=U9QY@_O#5HĝyPB[mFųjIӚOђ' 1|&T%VoYpͻذnawi›_W+4Ό5/+ntk+kÁ)#jo4gPҦN SyXp{Ab]һ'IfSd$7 ओ[S]Uⴥ$zxNC#%$$tO`B&|]d`Ȼ ɔ!RhkJB>E{]8]?sZ1\9QֽK,iH7.U\9xIزuA+vY?MZPC̢3&SXÁDZǺ䥜 U[59%IqZjZʲ}9Cv[QB ú%T9~Е- ﷚*JޕwLH)W1%c$0U@WF@2T!顝ZfY{.bȜ:o+_#*)Ə~'>{™-^ǁ-w4GD9A[o~?ûiyV?s\ܜw gc)Q7ry[\#FuE{5iW#?z q|0aS78]_bx ?sA>`8'z!Ʌ_E̼-ƇRג ႅȬxb|MsF_bޔq(qu?U!-x'd^FƓX-K,\zJE2t(K EC`•ew#δvt# N t.]r)y{9qT{S;|ժ^:T ۻuG)`l+(b3(54;'ØF8eF($U%LZt]5-u|$ЙH@繞@suHkEO P3( $+WC-9U.%)i4}md!)2sF} 3 WU__!dDTiH>M46α|4d37ixyƼ?`7\ȹ,֞~J$vH%ߥ,ɟ{A&fqܥ^ʏJ1WGbE^eASb̬}&>5\BT*{J4IL RHa$N<ID2T|XO̷wJA1[|`5<K7L> ZHݪ :/DžlK!))Z*N[N4*:v(qjJ2 <:bܗ,=aDF{7"Oh ڷh=benlX+c~ЏB-)M͵KHgh(Vwg0gC7Y^$}j{K(mGӽM+6h)̭ڽoW<^is:A}&*_re" EYA}К K-izo 9,5;xـ\b LJڍBG2r$a<(yjP<@ۚCQ-Є.1յj2lNB\ CV&,$˼NZ~hjQp= kq [T5Ȱy’#'Jvkl$ ڟTkHX*Q(fLQoPâ A.lnSy.0q6z:-?u4iCOpP}fdFXihS Gz>dղI l >E [xtߴyL%SLjof`N9 7|"%A{}^Q(L֐T~7pSmwb{}H@b7ZW،V"1pH8YDW@ 1pUbnrR%-$癍k?•sD$/}nH9n?ߨ4ԙUs["H9$[f|'rZf:q4DQXZ0oOis\kөvA^c2Kieuٿ{QFns7dQMs 5fBj;EwTb#_EFxPs ;LQrn` BH٭vˍݑe|d"z_{fڴn)^~ވ, }W)_K aBFsJ v+i[-c`oE;j]Pe|*ҧ+]Y`(tKo-;KUpr}U$ϛEV⑌(1d]qcx]c2rjʰI Ʀ k/*w&:+]m}h]6fTr7J]Vh>8Y睪wMq;f̨$T qʧP&JJKյ+vba5.Ky5YJ5x,u L 9c8!׌!4 FŦfV7v^.hWKؒݦVzRZI/D)OYQ7lΒW]suܴV̷_QZ~Ln)D=ІuzRld-0j}wF*¶dkVji cn=`!\ Gqzfls`pN6JVoɖpjUB{s5AnS4hNw4}~if׈ę44>)) qP5<@uHl ~(h5C+A$ ![j6I/g/ۖ`Z<;O`.߈/cbhW64s̋j6nJC'nc{3Ɉ![%XQ:4~-~.*oWwr%.wieC+oRBG\q_Rp`ޥZ*(OMܒg`_Ov V+x2#iVp!~Z 1a}{#Zt -#em:N6Rm vS& Q]]qX" J~ 8pMJAr?jLOC,A9 U` $w'Ojy:J_g'Z&>9J'Q fǠ~;KHħۗ @*r==:'02"e%"eNL.D-;c|wĘ]]@&O|>C..M=U]lk} )HLZݔoz əꥣ𳦖||I̴-)ygxʨm/#>,h06R cN(el_Qjw#P.]4QNFRf3Iٯm }\f_=/0zEҡ~`Yɖ.7*'W uTgAy#y)ׅ@w\1ʢV)1J5DI/N A,O&N˓["'#5hl=]tr $hP[N$I'~ [J9:4!5;dEkC۟!KJq  WНTٌ|$*Yn4.dFH+/G"%ggR)0R2Pd`uIJgxxiW <rlے `{VgsŠ[*aQS+E0zez^,߾lEQE(UƶɐٹܙY''6cϘ7TI<'u\gm7ި迦/.POkDy?;нZPmNHQ]QTOBT1:~0yirzJɴ_7qݯXwl#%_ 2Ztz=ET1bdnwR3kt=\8EOK_2"@AaS…l:HB3pb 5@"-By'$ $11e{UN*dS%D˓TQc4.,MA jRYUJR'i?d"7gUy~`&O]ڢION8|6v%BvZJUWn93IR O~ y<S-'/eI}CtYtc,З[!BqM}z9Q@VC*Ȍk$ d>3EKniC0qVB򣍁}͚ Wg ՅS6ѷƖҝѶ/n~P8췃)- EdT%=E8B.\ \Fg67ܱY\Zdó]ϴ-*ʯK\@e:#u&U9( yplq&ѨQoִRh|y;w: '҅1́JB}U/DeLAM  U^݄r0b{0[עe�!5klQJ |=.6j2]Ի%#ٿRA)I`eBN"^r3 % TIP%B!T)d]"DdL^,60L؋8Ƅe'*+]כ'PHN5վH,?g[o>VE}tϴ]s >u>0ξ;Q1Tz<d8D)'-Om;Ǎ4+:_3@$;jtO~}j _<´1ai--{=8z[KZӗ%IE5"+q015~QjyJ[{vzJcA#Z # z®4j L*l!36b"ݠ#Nn^HeuZ; ؜!u\>6 $2K C,r8Ptr<==ao[g'j9Ymb+zhS#'giKt0&]g 0G:=%K>3c̈́P8 bPy\LRg4_4qol;cmA UF#b!:I P}gT$sj"^BHvγ4*8uv٥C,1`B(Uz<摜A t|2df;hʂTK*P,`+2 Q ҝjO]I775iaoL!1 xDNM5ѲwWc?`"iD]R9Q@b”akckksZkLgeɎCQBP^YT*B 1S2lh֒0cLrW`dfIwM]fLS3:rg\* Q0J0 u;fI}gَ@Cď;V_ZoYNfܣןG% s lKUwcBQ<?q\SmaM,[^xގ *jwgIl=Jw&gVW"Ml*N`>Qr2 pn1x_ f$D`r9*iA=FcdRk8_G}i&4Y+~1A;:YyQUqRAזMS_rA/TJ ZIUFAG"bv ["v %Y[In[0mdHay&K$w:BxmyeʆNɥ; ]%L5"R4uAko͏N(/hLDHm ;i\ȁA av.)h׎t[+X#κ1}RPR)u9+` mՏf<[GB  B'Drdkd,?kX:8n0Rwk %%>]AFjQ 8}Y%NvGlV%]w7)4GY'@L**ZT.c㤫 \$P Fo"ļPh VnD *;swU_a.p,y5Y+ |0ˡN΅U75YtWȟi( )h$~=e7G4ϸVzLLTj X?"=ndK-JTM'h`NO(Cf#)j L:Kې$F(U,>G6s2d̴H݊Ze^NZ 9|b]Pw R۬ o?ܓ/ [74ރUZ9ѓ`0P+1nXYJީr#"*-W$.T@ëx8A-jSy᭪uDGT%V &u^ &rjdwIҌ9GDָd wO,ZnF8v9k(DYl2o%MZ l7ny#Nzgu()kT)ϫIO$8a+ʗ-q"\!Z=^X٩\Hu(3ݖ-c>[r1BKͅ aŪA~.H`nBdE"E0Pxա>)k[Y} z}#H͙u!NW`k̀IH/\FNK8RD6+` Aˁ (qTd:%Ђk`:ҮIɯ*[ت@]l׎%qnF-Y"MKJK# AUu/Icm&?(1ZvVuznc8!J6f%HB"Z\?DrI.c(:ԯ%v-3HgmcXΡb-KAܔ~t?\{h۶2+O'y}RT{:y⭭sԨ~XO[+>i6Ӧs8vBOɖr5Q❤# !γfҎt] |OQ1j!# ?F=Dр=gےwm)Yg{Qj7R}u92j= n'ƹC8ݎ/0讃oh`r,KY'юs8(h2 ,K ɵKj*T(S7ezQZwm2ɯƠnWKQh=!{}vR.qi&[2P6}OD\vv\H[ej/jZ+6I&2Bv*jF1/h1V}8[:MqcC^9l.; pf]̗t V%{1q;F uC]bב}.>itUgDc)1լhb&;aGK;9md,?%}4Pג0*u(Oȶ%%Em3f1Vdm|N޵za86)zg#ٶrebulPB1MC ў{LԹHN/NhkNuSbrQ x /8$2LLc{c"\J-K@iIqnf1,*J&bIbkUβ>ԥHT0].'NϚyZj4ov~8SȤ$InF4IlZ:O|6bSO~m'Lվ~Z>' ˴M}F'.r}kՊSLՏ=7i?oWCrGơ?  yC"N}_!#ٴ5po$yDw^M2 XR(sA045/-fH[a6:k &Ħ5'H8E+|"<#ZL5p1F LlϗEl4J^!%=zREKJg0T!KRe橊R"UMEgQmt>%q8-~5|ǂ&(#Gx_N5De\_qe\q:s GyKiJ 8~xs3xOLh>{h2RY}U^C('_8H Rwev%P1]e~zQuu>9{ si"'<;e%… DRfU .^mU‰VUƭKmxjOVc0cKIzjNjIटk:smv Bnlƕ:Q8jCnY1pgo~"y[Bb^ _¡| 6Vg#o-GO㔴[20rIyUI jv,s+?{Id#E0:JwNu|5<_}{KXq@_aÕ-YRm(.%o0Ѩ5Jl-eL9ucb좁+]XY:} QZ{#Qm>/|L>1,fc*L.gGnW!ծ ; #L*%wmH~{c 4\>4̚"i b6 4?at6 ktQ)4p8B_ż=Ty 0٣.#XeM ŗ6u+')輮 z̺EHyόil96f J@﹅{,0q'߱CS `s i#y}-SiE@1Tه@wAsRChg!;k{cEcM2YߧL^]*Ʈr  q)!?S%I~e;uU~;]/f?bq " w5|Eؖ}H |$ξɲ>m7dW'q(cIQI'4K1{j۷7n$g|} yTI+Y+,$֐&iRnN6}#"!vPWlӔ4sf1' c.+~,~ԯ dluΡxӹ#hqq/T_yr.޷wHɗ|t(RY:cx#bSM5 ?^ 쑽QwjJVii% n亀 BKsMyUP:|HM6"%=; F6@;ޡ&h&KՒ-rc#j+ވߘ]'~N+}P%)!+ftB9.ZO]N tN_K59rri "dſ))t I c+jP~; l-JWFl5!<>{sFkrA*C ?E}*^2s{Mrpz^1liطo9mBojڪCMU tQ,}/1@^'KyWnWrA@1EdA>_oeHLy߷ HP!-GbOɊZ^pZ *o$: #khY+ Ws/->kqo]蹣g(F 1?d0the.ptjdd%.DWv~fj#Dƍz 0]zfj U7D,,ό@(LE$;_T&m"$gRY+}CHUHVM(TvMDZqQ%ע\1lү]Y\dM_Ѹ[f*1{Y)/RX#rgk{#V,yݩ?هh{7?&N@I9Ll9UaUe4skYyR%ԱUT60M-GX94P@_.Ir6@)r_VWaz3Sb >*C-̗Kx\tY]^m6#xh뀻_am'P̟oFJQ(rnY_u}xnpಝ coRp@` 0ԎdXKVf@5<߃=xOSEnnJKwѿ> ،M ϑU7p"C :R@4q ༤Bks /[ݹo7rݷX<glߢ%%o:/%ɬ!"( ).'8WB 3կi#w4u؝)#2*f*#+$bdhr 7*Ea%_\WSo@ [+J8艙2(1e - s.L 9 gNuRA$[5>u'Ld, f\"])/cƜ;%=cՎp]bҼ=iH43QfTHOxrb > )9m,eX!.m,pz5-ITV)[|r6TV {vezdR9$6 %Nj%hYtSkg[ >4h|#}^ԹϮXhIӚK!L0e!0\j!XVV2* K iFv,,J a F?¿zԢ{r;ϧM8·];.ߡɡ@|lA]GF9D+r: { 4RZj9Bp&WG,~aRTÈvl|V߁INfPv._A.7y:8D-z$۰Id1z3Q*NS>ĵDH>ЩFbsYzsG9^qzdnj=F=l1S^}I5aQt:]d_b"ʓNnGJ kۼ/>gLX LX -',m*Q3:nZr|V=`k/c.q7mH1|c- ?pS9T-d6811M 2+DuۢsIdg(HQ6=_:(!Wuc):.CSv%Ͱ N4f-=8<&Ns/9H'*ʺ"/r o[irL߾a @dcQK~OY.e*\{tyGHzL1EB.5%{xvŸ&CʝpnRޛf"% +$Utimwm %ey澇 g^n4K "dXC>u;k 9!Ms;AG n~ey(9S &$GVI/Sp(2kؑ1"Z0s]{^"ʷuV)9aay{Zp_K7ˡ}Z{͸Nv=s?i;r[.4S Ы4B3EnӘ @| j3׻_ͷ g>̹VHqFD4ډS{Jy=f~CX$f? K7/bU#>'n܊q=ޚ=_-y'goz^B9^A"BB"E: 7MF TB4x CP5p"9d%Z2ґ]K8^B#[:ۅf-?uRCA/o`<ȚHqNˆ:c<հٽۈ&Bz(ŠW/hK@6cnL&] jγp):;>#'pt&X:^"/jn?zEw{\yM:n_s,+='K[WDZ"֔究VթT)Th5[r*K"I9#|-PKUvk Pu+5Sd)ҏIJEwTgFkTrpPs/n cקG;G[W W/*cjQVS&~E-WRK Qpe&BeSۨgc~Sf1\ T,a f ׼KR8㼞J>qW%>#>179l)Ѧ 5\ZXw_%:2},mw?xڍ7-E]XGz ג`'2j6]y] ŒYGJLML\+\5]5Q_uCvVS{4TWuj&d5?֐u3rPh% : m'Di:`Q>Ҋ9-ŚpHO/?q䱌 u6D |o3T((,vtdיdyD2*4xl6Qs)YTMA$&0P5u% ?Dl)BCIqs!u56` ŸzYo ǤԮ4ZaM4%yήNޑ[J3׀tTrLTqG1j~?)kE_E;5K,D9hR?v-z@\7\߶ٳ D/0.HFga]*xDʞYlm(A`SrN(P-8̪N.=߈vq1ʴٞrVЮ&)KyD(s> xT1(M馒@kRvux &X3SҿN b^z+iU~4P!k4A5\݁@wT)ak^ |㉈Gx*r`ݷ>GoCìsvg$'M竰5 K5Rml/ kEDo$esJ:m .m>>^CկM]Ş򓈪^$9)\KtWt)"Ҡ]b<-w{їb;ؾ%%|**"F7h{r_D]:0cEbaZʂ]TsD30)CQ(Uq( ,Fo{(.8\WɕB~D@?y:PwPA}>3αROq" *,pLb6GFlU4$z]ugL d0pMKt-V<ӏ-(?r+@^j IFQE{ !(OS2X}K KCQⵛ'cz }nB (z]mjֳWXP4g[Г4`ŏ"hۥ,g6+/[ $ nǖY%sK)NfD5F{GI r^}Lӈʊ%->oy*K^j K|^sJRL43KDi3*)v[v<-?Oy[y~T<$.Kg U6)?W1d'0r?|sOycpH4*4&I,_br[`} o->'Sya/U\3:r,z jyoc.0aI1|ɱ"-?HSR%@\ʋ䩢geS$egРPcQ/ Nennօ&,CǥuT vS3Y^--8늹&} D,:_P"D492@W_r#.Kջ[ bԧ1q|1a~Qpi\Ikj28x91!+,%&ZItqI=9g 2wu>Gt{&X0LL(tS<k$&m~9ȹ/5ax֣1zt'F/yaFVȼ@HӘt @<<B(5qprFVR`N;XkYSG ](򧖉?x!)MwpS.2 xWG_~1Zp㟿Cm#ޜnv#p~Ҋ;ʆ *r3g^` 0Jcv(V`iΐ2`vpʹoׁ+o_^da~z6segbj'N6IUwV{h~>+ gE18IPw_^y9w?YUpWSb`Yjܲ_ERo SUtA%85(H˅iA !T!h!BhBIژM8^RZLPέj?wc#:gas!P-`ASjGdj+d*W|b҉ )dI&EmL=Z?]\jKjM)دnv@,˖ d1Ul$4~.d׏K^謨fz.e.vRK̍[R6[WR7ն@}8p=gی}vPH 8i((D.]L4fW¨W;޹-_5XefZx۪];`#k*^]w!RPezw'¾ze!paӆ3UE$H؁՜ӷZښF>8QFѯߩoo_ 4 lÊgQK('*ӎ[Wi&_Ec g19ef̼7/ pHCU_; H 86et^}ZEkoJ.򈍧볱YWT0kT!E(&Xf-J Z`h|qEa< )(W`4=hURFȪ{і&v1@DzDt]C҂LxF\|%Vߵ譫7//28\Al&Z1.C)W\yTE<)`~؋Lqf$2MQX.Sxi%,i 22_!/wZq/ &z Ec尖vb4Vg,rq4L]6%;tuX/Ƞ[ո"΀:4BOU4',Et ,5|%UP2CJ. &Cżϯ jj=f/FFkk\Lq!`TA;VУ|Zq} Ԓ.SȵI4Xl .ʮE^X~U2|j& '"|,Z!ᏗTyMӤZ'$,wo$ mm(D>%ZhFE~QSu2om:x9x?x3|OVRm(.i޲BfTnW탋u s6E׺%h:cN;yW.okj+J#H F|[uQ'0+{]ѕ*#~ֽP$ׇFϜT;qPu_|(MeU4F<90b ҉wD\k7-(Une@7/٣ٔitB!L.h*Z(UQlWҚup {cxU"@:"&/@*k(DdU\h5aзC|K@O&CMG7>эn|tЍcU :Xn{6oF@WLST4D{:gd{p"TS hwx|#AZog{ 4=G{ 8+Çp>.!}Bt6] D2wiSo9~9/>Bи-@HCQOa1o=2˓uo; ߢԼp&cYB"q O %G!"B  "T*.,~rCj;,-$V7mΕJF!ۯ6bdF gPC p%T[e+xH@$HZEqN3TEK@c9>4Zqw$ bMvD^I$J˱~CFKnӵ4$4.tcnhk43I(AF&M`ʧ֝6]hXDIV#Yw4J^JCg7tB Jx+y/~=Kr `j60.\i jXJ/D| ѿ2M"&og^?ĀtLPHk3Tmdl_QzyzSFʢɆqɡUd%E0 KAJ(gnp >s tK%״Y\W7z}6ˍgɸwtd ;38TY6PE\Y c_׊#mtY.iF>ź*Z"zLXWEMrGǡVr5AF\PzNғH~ޘ K4M|sg]6x*2HZX@< j&JUz.*w.Ƙt%m6)>YֻԴ:29Ap8 !Kv-!6cpzn0i)S a\Zm<7b-"֥\AĢ)8#!cB:|6l??; d8ڃZ8xUwur= oT2U}z9Jr=;n=/-ύu~~P#]n|O8n|IGMc[}CCѠM.D 5]#Ƃ+̛^(rauo?J?)@ߖ[g5u.I\Vu(ig!jP~GX)}Ig¿ q3m'F> :iA(%mI)Hv֛pxp$sG4UޭTha9TF9j{k,+xȕK?Ԃ$OzV~OX + +|Sb50!CiLC|'w gJ}:'ŞXMah~=iQuqRH83sq!Q oL׾/ Oſ`.ʢLJ>Rx2^W2||m:+YzV@l; 밻iy$^dw|~ƒv`V' S7cҞL)Kuc@Ő/Eep2!7YGMn)G%+iX˙pgniN,Dt? Eհ%Z4gW0%(޽sMl+=_MtۨN;R@[e̺RJNa;#rļ WY9`&˄~mAqL:xvm^}qt(U>wg1;tisgrquC1K1}2͔ϫ|"2_] ۝  Jaʆ5 0uO JIkP%t+"SKKbW_xTZ-T\*九]*/$l`^Jn 蔚¢7NP+\КoB1[Zh_r+do,dZ߸$e#+qǺD:+<"7Pi= Ҙ~Qw2e meVSYR4seIZ(.jT\ܗ$1~&~<=> i*ÔilE$&@dU3 bI fy!!n;pH[69nNNJb) &lnj.QfӒ`#ǸݚnRLK cbWVOX2/-/Yb}K$씱z](VaTGLًVHDNN:s]Yw[]R'F?N#_Xpѓvuv0_ ?`o;s(tyUa8~xp4h0^'D̡&1JZVOUUR+F3tHS\i欛Et]B2H&X0V.J\LF,G;SH|FTU|_R !yzS0\]!dZO/ ?7'-\;5> :쏑1?F~g|dsKiQQN?&ikB1Vo,_C>aDKmĺASn&2;;8XZgbDDs \Zoi6Fo1l~-xзjZѤ`X&eV6idžLԸ F(2V`Fy01\}*:<<"?Plfzęl_%]!5g-{vOR>_% f ,xw8N,}\_Sc^7 ;>׾/ùnMg@e{jeԻ%[;jꪐHIeHN Lt: MJ 筨Ҿ>]BIwF;ʲ^RpoL1pVyǯo ;w?w* +֗ g@RfBJ^, ?ߪ?(XՌqk\-ǁ[_*i\z[xru2_΄="C[MsrsPIDG9EVnl^K~Kp-R nｺǵ[>sЖK1\'u! lM.nc[9nZ\%3tY9 >_ ׄ;aglx=9! 5ܜ ~J(Bo#ѝ$q'msgf\2ϳPv‚W($[=.6x^n%0_BOULRSRHT=UtuI'\1eKel&0n(WHhGU|3V!Ub3 [ES{FZbr)k⽞ÄCԢK lxW.B}j%n Y#vasH^dgghmJ?K}Eԋzʘ0wq"Mzj.X[>4Ģ iV(3H.\E!V1W"ԩrΔZ1c) 9/gp.3H如I gԝ,h|`L@O Vs'J&YMGqljTTʸ"JS"Dߛ޺#yA[/ⴣk*yJVZUq5R3{^"HdW\`+=-7˨Uqǂa*h€h?cܷo>?~ecII\E|:P GeSrӓU`Fe5I*.:_>$c\! ZYn(֘w\5C&fyxRJV*(SR0kwyS@^lϷV  ]_ˤR32p{DX?JZmּ٩F7g(eJbdOh8}zȎ`0&`b]\D~;Q ) s4cw ԝ~$kN+6*74zm(RR~pkک\"ru{689L2{19j+w EI>$9U"O| @4yD5#mGaQĝEE~"੎ZpR`|[P:cǓ˺iԏb |ʿ jVca%.K:x=Փ5(& ȪNώsUOGr/18/JD|+'Έe.FPCrLj|2,LgiDXp2i*i&5nR6.#V}^ nNEd#;խ_hVlǯ wfV$x5/wXmqGٖt2̟\k28 Pk/&v. @49+ۆop@keuJYAY@xj'꜐)͖]T z|^RoHk>:]7+^QlwĞEܾ%zKa9Wp׋ss1C9d*&s PSr9@a0ؒ4GYH$]_@IvBHĺ?铹KX98մExVN5B 0]KF2dQ;$ JQ ٬v D;9ĀK)o "ŗZE&FlrôMLT4L`r`Y X E{4DuNO㘄}nHmI䨋ku\–=x$\CHge[ q?mױ\c=V'/h|R"#$8d#n\<$ķ =G(o#n3'%tIհ,p'Jqi!Єr0N;$m:he@4@DFFhS+]T+B탢m[7FB/8|J~F>I7xSZC[vpSKd,4~eA-,iճ%,['sX2XQERV$=_þJPY)O Ђz.FR*Ɍcܙӱ0h$:AC3.M/6O'|ls\#%󒟉Sѥ=/$%3]jZ!^0p^wǁpKF(~IvȪV4O SF(™0@eU3\$36̕OHNŘiO[gPZ4\yf  |b`Vgke撉R04ԒYIvIyTAȵ^p%|C*"5fz"SFV9Kaw,.Dxj[Ӿ)z q;ЧQϨc@;be<,@mݾifJRYDܾo5,-ڻ\ӥ Ÿr*:GXgZZ,wC2>`=K (H 08%0*`^WجƸ ;c6zȩ=]>7̳Ŭ4NqH )  w93w ՝ auC  FB".SI%BۼI'Z8!\/C@;ï"UIly.i(0tV}.Kp~,K@Jߖ}4 :A{&=Jgx,0T$I-j!c ,E00;gБ&>ޙ*= JӺ+*ߣ@Qrxׁ΍z% 8I.49 .gyC5A+Ҁš2U!]к d}ub($'fy|%ͩՀ|ɖhkrwnJBfC!gS_Mky);8f~1ӋE56%GiR{7dVh:M_MsDfLr[SgCaPH5׫i#[.N!n9h :C((Yo&|#% k~kH| b6DnlDG:"Zkio3]^X"6+L&+jzJCJί!@]PUj73C0vE;Lp*HsB\zs;Q=;y0E;mf)_ ~2[|wV[d mϳ/S6Mvcew_n[{33Cc.^wL,ް;=6Mю)f`,1`qQ a#qAx_Hr\EGZ+Hpt| 8N {k #mp jvC&h(>7|$iL 6U4œmLISlpE|^ʳ=@^@<. &kBQ+rENIp'gǧ,o`@ʢ{w=L1ꯧw?tzF?wZR+,R;2jM/EcƸ ]|̨y'ۈ*e\X(Pj6泺Q觱4eYZް2}YކEXGs:lm XfNἅEMc]/8VUMBr1p@8v |A7\{&+tŔTNk.tT3UPUw &š"+N0c"x+/6_2bG"WC+q&3XAug-0U$+ Y,fƼs1M4g3!K譹$=Y53Ϊ-y 4-t,Ar2aĂ

#YJl џ«V[^ϞN j֭8mҫJiZr%:3UfR05̽pwժ-"lvVBz'e†I/W,Zcf8WKƼMgQҀqbGd2Lj+j.~%:T))$4EHǚHi9cQblJ1lQ5 E2=#2(CM#Бc0z/ƒZ-[(w袚 mB'k(E)YV3SZok{% x=. *b#/zaւ/ wP&l Rq > LE=%l XC/#d?LVa9,2o׃jce);}w:<*oS)26VOĚ ֮nKN5L 8Z(\Thz/+t^,3dŲ7*fLo˃ZqFK(f0s`jPQQS)7wgqǒ"I8>n hgKg0Z uNa}0 yeXI*.U̝0p5qY@?ƌҝno}NW]Sƹf׆'9pA)j,\I 9.b{FFƐl\˛ .B{ YIyd71_J%:biW;jIfTj瀇JU e&(>*HدfJmUK\yY73b~3ˊko@Bh`pvT -G 6|kq̭ҠfT%RF Ig̒6RT+t "GtW'Wte4'Öx<,E=3W{T˜!SOYj|;c49m+-5>#v~QiAkY5!O{WX_69^i|DE*^gsҷݥfFkWGnNj4Qr@M#1p쮒E2w{)-:b(Ck9y$>6)C2:,Ʋ!zdXX0iNP!֚3oOW嵰|{O#HG(3fzfxQP3V;m+H3b耐_+1^k9,hҊ #0O } $-xQݗI(>Ez[x. ,ڠ8~&P nrݚ^JuY_l||G0I[^R`Vmŧ7)JVťEbZ!Ut[C.S%"_i1gfr-7;[#S q.')#q!h:}Z M*R9ƏD'1/E&/ ʖL|OS[6[ʜ+sx [+3Gb{O8aA gtuQ(\0MVEѾ\nD<2ޞ=${Ac Ễלc{jdrze~oX[Pӕt8 RéB,UZW@ R1Ő U /uɽ]E +oi3 f2>}8oi)Љ P~2X4A8u\G:FB>%"f/c8v`1P=uJ%*wyx̢#޴8:;bY5\eO b$x,ʳ ,=*uMcBNa\=OV qV;qjo,n%Z{w_U22=jvs;URLi2lj_Udb9#"Myv#%XMD t/"BIķ rr_.cdP,&3(֡2o<3+ 8 x;;kf [FʩK6 1ǝi-d1̾ @k :,F6{sE⪑od@<,ԕ^"m[5S`Mj̩%TV'վO& ~k%?}*|K% y(-8k! T~l$ 6 !v2J\YdqsE coV'hKq k/FVpS%d5gG,.9[t7BEkH>ϥf0^0R.^~K"*Ooĵ \jߨS~+US>rmNU=D,F ѺXքK~/1<oFa6+)~xyV֋T̵xNbԫڠ vX$C:Eڤr$iqʍޖCxj-ߧhs2 5nW"iWA'椂" sX2KFn ;[{z΢o0Є5Jެ>';^J.qj(cCKa!Oא- V!w?$n WTۦ?gJ}jF"` |T[0[_k|4ZS3%Rܿp>;烦BbE;U?'@'EPʀv ڱkZo$:"&W$5 ?*1oTHi @M3>S𯬽<^3 jx-j,,$ 8%A'hwB PZz6d+DUR-HT@ETNɅA,/șHJ6FU4RӇgΡg][6W=9H.qwϹ*P c;4FMΤs/Zq O@.'rjAnfBFI>BGyB~陈"N9HE ߃ܷ0#N1i@>~LdWG}? a'VtFPK{XjjMsY|:K*Z^ X@MƠtCR4Lq9؇Ӹi@[*&9}'V.q; fFYS@Ye-ҾSc'˨3.I%b]KB]QU{i5.iY]iC04z'] Q3{xlV؄^uUTfV*[[FtH.mիܶ YVR `.DQbqv\O$[4|9.<|_G=?2~g??1~ClB zwێt ׌VH1> WiqgPVM 1*L)Qdy(aYMS7Uߕ=Nܤ{waIY+ Q΢uΓNhm.4)cy1(LxmNW:Wja؜/n94ӹ*W,0Bod1;b xC}_>YWI?uvR+1eHtf_4c<ɸ(F#W.bBX]Ս\@NZ[ H}]iȖ\T(DcmG o˚mv>m?F5B6wYRIZ<聱/H?B5'4QB$[忮Y~ Pf@s`I1ۺsoz2tc-D(|.bj A-y Q4h;\H|(5iRz)}z2qӮ Da9Z9LLdR/7zT)8F+yzǜ`p\$V͟6g3t`lNbo6*zߧeZJ0,y:;39Kn#F/TUJ]@D]Tcrc7{ ;{-faHz]kۨLs'б~/#^ঀ3u0ڸR0chA2ߵ@HH_<' 1>p3uOm7+3B^bEӵfz@ Z)^ح]OgnZl PGByb~#"Rb8HA]~C-eA}]!=><~#WGr6dv%< lt}:&YKR`i&\xfԟ!jZK?h{ݱc+)Jȉ4;x6JLt1 ]2H(r]QU{0tX#M[ L˗աݫGj. {x,VXq\0//N%NKa3r Ȋjչv6@yۚ^nm Ypky:/ 5q۱^I껷viN r. ]xIϼ8_ZvACЎZ,늙/4/B%Ư{vy~$I**&RV?dmŕ~gfl[R$K@f#\JcN9ΰ-H>ؐvS)H2/v2lV1bW~tbf_GV.Pb!/レWX9nPc& 7j|꽣~idxD`, sT_(̶ )uNJuWrVq7"%_xE|]`hkoB#}eRP%\~Ay-JR9RӋA]WXm:6!Id D:E^  yBVsGTdmUCFeW3j.4`-,Dj悯 I% a 6r1r\y'Ϳ5-7j+9x[,_7:2 J̙8BjZx I,&J!W9DE95"ijoB“EArqqyꅷ"SCd9VPZSˑ}E`c9~<4+rf?4C-Vk,U$˨PnjU9|F?XsqXDׁB)vjtO%Ҳ;`jUT;^)53hUTPפnˡUB`g%"nj&X ͕p&K H6:3=~7 jH%VW %,Ϥg# T}ǵ70>:P-xyslٽEV| g RW I̤W7i[Lbiҫt&y 9N1xb"jBzʷжHGvgmF۔l~ *҇Ԭ))Pj#\ȗ# 93/E;pIk&uh/@9l %.t+k 4I+Ⱦ㒋&=nIWw*ZTaV(妪| WwTI0$ ?)rjLwhaIעԔ^2ᶒAo9'.94ig68hz]ѡ5gC-nZ'KGAcN"ecSvsAqA=}Y rݚ/[lJ6.ozܾu= Vuɠq4^Ur.ϥIg3eE\%%5V&N,4Kkd02wB#uӚjKVnc @v.6kM9/^伮vr:)nLzb)Rr.ߎmI(0VutXYl)! uOJmw nu$GNEQfuP@ї2꒲uSkfExT*l$mp5.ז=߾=H.#Rc iu]r{\17:j2aW1JB,Ruv;J6Ħb34{OUHҮ{$D KoN''[aj'䜌-zIܨ&uX)5OiRDŽY^=-^C&{W R(UU#% M7$ѩB 0R"Q,&2Y{doܴǕ9lke`q).Q7;lb̀^CUk]ΑoHh:Gb!+Ad:\%oϋuAtݰdN+Nde l4sm5\3"Tlu{leD>%(i4 ѝ9o,@ iR:hIGK}`Q@,,E?7#Pkz"3_'\.R/nreY7 nѢ/+Coy˽AGEѢ'(˻:MYHMʅ#DusGJE[ze5_yW#ޤ>f'Kv)P2O[SָJe%{MQUOޏ sw+疖>tV8)r0VsBiqsmS]S*! ᘥ%B?(٢ %]ܸWzά`=wiG>Nh9eͲkm9AnG\S'~!jrcrH"ˀDRtkoŪ\1xea ed&a%,o ϜCՙFJџ{"t Se/ZoSA{E}/1b1= 6}%nz"+Y(&ud}fMˀ4 n٬2zhG8< |̇f-q /=ҹ.wШ֖}cQjzg 9rSVԓ`H"~l m Ղ' `B+8ɹIޕ!%gSA{9iJ' 2z6*AoClׅ jlpMc6ψ"FOZ<K"֔75\C9)͔tcJϕ~%෬E0e}&hc,Q+OӱsE화k#MQl7=;+ &:'*H_7Z[t 2,1#ZgX4oCJ@M76Ќ@aa6Jnzm |z 눟XTP-%F_a6) rLkLj.i׫ Bʥ%%wm ) @$~D̷ה>wX(0Cp5 8Uȱĉͤ50^4jM䕅܌& . f/gˉ ))W_HAٶ$2E" B,-2H.(uAj$)|S&e*x/CCLCNrTߺ!֥X&*}/.x#mLf =MmdMzѢ۵(b i9d%ą w@ySyk~'E4z {Х2]|Ip.!7o7u!wyt|PJ*ŽBǧeMJh֪J՚b o>+k{QyOT,m4J7^2Bʊ C6n"Ǽ?؊ɁO-Ph3~-s&\SM5Z=6p}͡u*#/Wzϑ򎴵|jH餁~ G}R)d>ԅ[ebkfHgc[\)5㼴QkѦ#29!/x^Z 18@/l{3R_oLU+AnUmx>yY&;\4+ZOw!_P󺴡MQ \(WĦ-FVMt_y$aP*-N=lyC#ooQk1 Ts;iu,SJ@nv`|Nfڵk_UP AQ{!G<ϳS~r k:vD_Lk[1NJDǛ>߇ihUw؜X8EkTF"Ӑ||ip`u()~V q˞E=pdk:9ћ6Za%jZs3@) Nm{ꔦԺ S%)PC:j5H}g<>ư>O/2hQi)eE '-.4wu-ʲ1e-}jL<| T=Y6Qi5w3CιvE_9y 1%UuMD H$C"+ 6s ?9O  ﹥?VʇϮm")֐ϕ7ID>߻}Nee k#:S):EƴUJTL*fH K륥Nj xyF)SO:zHTǫonbʡGRn2ypnc=#P%eKt!ИN9"{$85jIQ?-1v8bz~ 2|S I~E yJzЕJo\Rخޑ8!Zσ_EߌM&Β탓ɚY *. N*T=<|B0FѪU?Ԍyr6 ]V>WudTG]Ā TBz=|FKQAa)<36i8 C`v vɁV.s(`k:E7+l2&hK%V>qa])';Rp$NREwP^H8wd+gKv Dk nT1EM_{Yc)﹄z/n^9]UXc<"#Z"-Q)#1Y*)s:%E!j# mM#j~0BBζpP4bUwBN[OhDX4GkRM)U2o2y%*Ao,4ȷD>xM4$<)DT[!C(Pnj\!k'd uPLEj͜&4:w|SS3F S)-l{K@4C d&a!Sc!7DUFoG$v?ɢnCޮ`u}hUr9<~cۚ;O"~<fyM"FRוB%xDχmV:*+Hg`s t>7vEsfg`.Ϟg"9(-&%0393L3H5M ~;gcK$sa[F]|5(Oܙ__w"uG:9 ɻuL ]sXIͽ]! w :wƕ#$__eȜ\"t^Ls#-.J<9boQikˀ6/]tK/]+]?|˖/[lb˶}_/KLTrGC%#bhZLT^&T+bTnuc$JBgRQ-ճ,C&W,SW7faS @TO6\ki-S"Bt6f }+]a_XMܕ3"h**L$Ж: r~n<1Q(jDVоryNi8H*D6클ڵ{^+o+Fveav5hP aQ]^X"9<37l%02Z(j rot%wZMDu?YYт/vd ףШ~]y æc 3ʝ:39H}(ʅD* ,F~:BAһI Zdg-48|Ĭ"t,Kj9Fd1 Þ$sU‹:ST?7jT6 㤩%*< h(^$Qu2[.uWvVȅkK>&tG*ZZ'ǷgF{M !rt]+ ^";jYjhkH9,A*'aIJȫ ^U:@[LK3H\H5˱"&!F dnH"3tYRi$r5ne_Q+6Q`vPC={%M{K&ŨfM 4)O|ۂpҭtT]Ao) e=)45WIi#)u%phd[=UJ?듮 ,5I&tgl(1e5)Xt ,VrJxbs0= *u&p܏Q6P@+ NFdspWs!VaPM ٨طA2 .]TһWU8w$w_YW𕅯,|e+ _Y- sl#~1 23XS;ݨ3cw)sGFFu8uo>*޳Y x:"ٳx>z#٥fnG Կ'y9>aP$>/ #L/bla1D ?/1/eV:*+Y$y9$ xRIBOrԤ[jF_.J nKJK!kwwӹ㱗H䦎{= ~#s&}1l')W6p ]йP) Vt0 Ɠ.sJ ݲhDpS(UH~RKcBD4e<E.甯QԶN\B.)apBJM B˫gkUj[O-$!36mIj(LR66!B(=dGΦv![$4»+@ƯƃuaB.'V:LKxdtjl\Qv8 (˅8<9VDDx~T@j׍pˊӪgű L+ԐNO:CЌřCN64}4x0ٯv$nV$;lt7yRɁI$bnd1|ԘuzY[MXVEra[Ka+NS}-vڿpMʷ C4[)ǠVHC)Ta!=L]xm*AOy+Jfֈ6T9JTl*|_'~"#=&#f>S?*NDUVUDU+- R>铯,魱u:o7Lu#L>)6ӲW3z5Od$Lo3JH$ňm]>lNN<83^UMMEoşP4%JsKiJ_6P*SAyg QRNUDaIpl}BA +B` yy g'XchUrP_igY-'^tHc**Ѥ3al"6u :T5J3Lnv#īԃD]MIE3gm} 5pA"h:s֞#fO\V]ix "dͦw9>LН4 3NRk$Eڀ=oٳz$6ei>C qZkN++p/hJjzI%&݊NdۮMYY RQ9Ȃ>Fd.PV=C@kq,-AYw cpl]gi,=M.1h@-YI,;7- tCݼf?kN[*_# DP; j;MfrEa$ixBL"j6 DPsKt< Y' N޸]; $q46brW)G?PGg/d $0+!dfMF4*lŖ7uUFg70qoS3>h]uHB&EHM5%XDX ڨjYJڥI(7KEIAϨ#ɥ6)*g5%ƴ֔P_\{h' >(ܧntE(&;BlQ@Z7;enK-XR`& VRHLK%ء1[sXN?=ű jԾӇdUf /8*٩C[3੾̂[3u0eոcԋtڗsz]zHB))D=Qd\ 2"VI;HK::S:n$gm]QkOIMZ l' aԞu5X68uZ2I40xpO57Iy/bP k&!!̹aԺ[Xשͅ@ꊂ}O8ۈVW (GRHi<&B/7}o{soFwıAG³~KH <3N)Ol4gD?q]h.z:~sIk-2HW°v<>>#KD#[?HDMCx\G=q2'ƱAy8X䖨!3 Tuo 0V-CR3DeZ̢nLhu<505)oӠt>FtYV%~[iTZnŭEk`YtSY>iV~:馽nM4MI%<<qmd˔쮂a"ipOCrdU)9ZOVST]g'LD ORR`D1 PXŸ}NJv&<\) B; :郗4db,%zބ>sYjㄥFl6+BzbPM7 l|x!]BBUhɍaF{00rR"u [4Zcf&OYQYOP60m6A&ޯZj2Ʀdr^!SR5UQM\@1טߌl6].L:7KI,ߜp5_6$&0͆`VqV rNW#KG6\J{:ІR  kBNfXk$[|]Y!={rcߤ*~"J;c}ED@l(4<&m1c*(% N# < KrCLl3+WB@JipAX*%3 UEO]u_uuT!L[痑  /0  "O:+U> UW¢mNQrQGjE)J`Nɸ'cʫfXol! \$$ְ#[ps6JA¡@ܗJi^0x6Z`Q962id}xd,``4)X3\ס]!wd"9U$a8V,p٠Qhr=2=BI_,Ir/tdXټۤ$'c5'FSAE6>X5M<Pm=VxGn9gk  mJXd~jkN_aOFk-pQ?\j ]2W~BjA5 GbK'Ely )vk{` ]2 7aVIS3a38euװz(z1q,kNl+6 Ti["y{oJNX[+P8:!99 |h3 ¤ty,7 z ]_ז̆E[fZcQQ΂]A!;4Z<3&Ln~nQ>Q۔DY,HLR lԏ)_yP{^}W:Beal 3Vq/Vdc=kPoseghROH Wu] '3}%M0T\1UL2$L 8ÿ:Yt/O-PBI6ƻ7? 1`?x1&|ezQRfl|{toJj6"^ED=I<YBt]>2vfI sl1(|-X}^vmWp>peSIXHy/LDjd#X,\JyLD쭭p 睌 *}PMG 9ѹ*FFw0GF} V=]1BÔq,8zqS H ?[ƭrq opꭷ״ESb%( sR,}NU16|ܖe4n7 a+}Ĭ$1Bԧ@HZ9$%▸,уkeIw-ɢdDEHЫ5 P44@Y 8\~ @efAX32,DTrM :v=a5Ea s6+tsʳ(;Q N2G$7S ;C#P?dU(OX|g3]K!+OA-Qi@ʇn&I)Q.<"fcigrm7"[?#H4&(rܴ)ˍN-Ώdo`yq")xɺ+yQon {܄a Ge5[E{ƍ䜀`u:-aq'ۿo0+iBAun=*{dQ3w ˼G`?WdT Cwt.NRTgJP8$M/V$]p$ H/R1Qоen ]›ѭ?SUT gQY6Vf_SLգ'aJu([>9|z}"B]+phbhehsen* dOaCZ;TN@# 'sjÆ~ːn/V;K!pʺO[W\뺦@Vw8HԷKy-*e *Bg٫f4/dWփ^-Z,)?U h5Lu 3 F~ D@Zem.bOɇWi 8;(1 6HɺYYÕ+S` gx8!ln9@8ep}1+bO}%cQV(ڵ%]qyWj2cA5;_|?P1U>Pyϓ z bg1oS~ R3sV\"MM8Jr{+r%ʸkAN}}\-gH^+JkMnn]ǒɬV80oi<1dK<93m6~׻kdr"+wXj~|TWE"{a x.+(S/2qDa ~cN CfXQ4LPIynMB)b =FXLb ڲ+KhE=`)ӷ>EzU~'YO)-m}A3^@݈U-moq h;'ٗGʢ3)嶛o{6:.M8n٦glMru䫾ihk݌mk3λB0Hл,:T)+/zu1ehZh~! CL,Wk'lo Ti,)쯖2R$jq/Zl6{naB ĝKvAYQu 렁֤f @#N{T㎢I.#' _Jr+a VFϳ)\哯j9uSBYOk:֗ WUX3-r*Xxb{/wv{ D _w8 Pye&9;3BOX} ٟ۟ݱJyƯmg1ST< E+l{2 a=$9uJ^s'pÃ#w`UbHjJxB';d6 $jF뎇Akڟ/{(j%t 6C ÛKK-T 8H T|Z䳴Jxl uc? DV",--7>8_3_?ˆJU ձ^V|t9!E-"O\'kud慲<=cIZ|R],8;.V-O{*Xq>zAoqR[sֲf'a1-{xᙬ'm͋cIPL] z%0n4 Ov5f5tb) VLBO:K]lPq'1X]? u^渗s辂?11‚-3\.yQRVP :ٷJN7vS(GP}|r.?YDޛDkܙb"׽H~r4&vB,%~lN״B1m3k|);=v֕ c/,Dj.Ucp)2 M 9my' ){б E72Gk;LaS{;^ qU@&*9_9K֝HP8$E/:c㮌JobaZ$ Sthas7ݧǾeln ԟ > /ETgM luf@_SXw)bY(ڊOw^$hjeJS(%B(8a BㆳYr j{3 &FY&mc {"JnEb'P%]eڧ%]7*&fIVxh,DdE,[ՠ5C:=35?Y-Eo䬨`G*O#Q(B&=gsF @OBz̃2@)P&`bhdÍAԏ0eXk>ž7&!%RE5hZF+"@c^^X鄬^WHLI&h#1f/aOSĀ@ Ԍ@m_z䚧~-\pZ< .<'g'D뙪W.hALKDvugB&IF}8kN#IMVV=% e$?R80mji<1dM$3,Xֿ#?EoJ=e|Iaּ!WHAH>SN ) XmX-ƃ 0pJA9~:`9$ #nAw6{04);+9!"Rɑed&%!5Id  &p%-O㓥WGѽB;{)о.(˻ \ [Usݒfʺ0q`ggQuUm?`{6+@eخMgl peW=<3kՌm ~5B1H]wIuD.Vx4gcl%_?/C{9E1Mγ\Z$P2U0cj8|$~>S/2RwJ=#޽N% ,vWT!?a4lf-{6A7FkfުTXC"^d{{N߾=*?JGKM@%,f.R_k%.qS[JLYOs(1UdH1-*mM"ץ{OuvҦZ D o;8MuN8-6vƲ;{.:CrlX..l8I`=aMa?,>Fa"?cC sךG%\.:*<}D0"R͂?/WRo {SXũ*4@*̗:sĂ7TбjoPZ $wa?3S:Hw{:.6uC#QMaRݓNpw9 2T3gWx'.ʪ 6: &{ V,>'`;Xk8l8A3T:ሸF0JvY3h E%Ww`1UhT̆H>e׹Mi R,T8ڥ^(j:{^ ZX ^\*KspңH*'+)Ն$פ_ElٷmVm  ݃(ϳsJaInz@;$hyc(( Qk2fAdcJro)*j͆E_͸^l$0^n9:cauK\%j<㥟L"8:i+6A1b}ta< Nĩ0nE*HӠ%~J-K7_t2|#oޤ>s/j;Tђ‰A#@B* f~yK=ޫڮV*%/ѲH_V%H3-Q#ŷyFzڐ/8;ˮxU$ѲhKMiX$$EoS˜uܟqmwY;E)ymR+2Yn51$xBUeb\gP},Cq~TH(؟tcTsn( )߸d4AEUw40Kq ⛥`jqիw#1E&}Xvp*5yl*{*N@͐Na8"+94fTzGuCyvv)Ѿ8eŷ6"6& cʝ+ 6<'Rb4R´uy+T4`|y֌u I* uWK k_Gd_!9iT:7'eG=l(3{,(URD -L:arÂ@.Z9d= E##G:@hRDS aKE7_%nQB(y1|2(/Sg@mCid^g{>U4BW\X-v`8z3TZWn2Qu j崕u-Uuwq#z6ekD&Y\+Bḷ<\UNƺeIskb!J P8F3T?b~O䎞?Tߤtڋ^xCJ)2ިPJ+T Mk]4xzʎ;~sv~RqPc "ۿ}ktS#Յʒ%f[% _e2R-:XZ<,rYCEN+fh\l5-l(+(9Lv\s<::"`))M P4mk |O$(]0O`,\\@`Eju/{a[1!Yh#/IK ~fTYǼMc_3>5'󍬒Y<^ ݪ۞b~q8Ydݞ+-`*#a 'v#n3Z:5GUqMt:74!`%]S'5GEuUij*2}0U3y&;ݪnc Fxje(р C:O۔xjA#8"YgkWpMvA_1nZu/q5͸QRǑ:|k1B4;92m^5vg~hXv';w Tˉ L ԀaHRA~,R)P I>Ⱦ7d_UBA+.wo*a?OY2c@n5* _ v"NV"T='rPGMY"NMV]@=$&TN6CuxMVlxܝAß=2S. ]hndHPUj=2o~c! qӌFO,c^& כ;ؿYq}iUE⽲<”LUZzLi!uT=/5a9G/H0X ڍ Q jb%J HgrLeNިiB5I3{lN(l}wCY2$h6K j A GA=Aiv;~V(M=qƠi}zSȗXZj<3f˗`55gzۦ/0c`-!hfW7pO\r cucr/g"IRIP)AJz)kb?ϧr$> 2BlQNO~TR|`/mFAKr jq#0"z'wmk.2L沮Es/F aMZѕ#TKvUnW,'VеGi5NJ%h%G G~=ϺmosAwwb0^5 (X-NQ8Ce7捏3'/TnCo۔U=rzV6L Q)X*?3kk) emdcFn{i:n;)z֦ zd %1]D̡SN,?Q{$rݭdΜ"ާ^M,Tyr ]}O0SLD?SN},)vGUWU5yMbv .<@KzܛpW! \rxQFeTdXM;Yi'Xß#ig,6BQ>ڤ"ԫaEL;>dyYxw14TպEnf5:bGn~ڰ۳F^5Sٕ%)L.A雚y>#{5Xjcq^O %#ݧ _,jnM7F4s+T-HCwpxĭ/$WCӽ Ib(c1 ;&/'kGnѭha'U6ࡡ|*'\Tη4}{:ĖF7 f*&OYݬzOQOE"X:ɞ ZfR{tQ^f>KHhWyRwToTRo'?ikKEࢩ&RՑ?UרU~pt濁Rpv>n ۬ Oꭗ2rZ~ؕBArkđvUL6SSԒ>wS3S^Oc~U;kP`p!m: geT[ B\cV1}\twb@w\E WAawwMc6\C[ VL?h;^t9{|vs63bCy@4!aEN< PS;L /xՅ%)_jkſ IF֚>hrH.Hl1l,[^+=>r_୪op 25;%Q`kI"'sKzC݉6ET&+;NNC#qDVhsҚq.>p$unf5w˲~Ln`: -b>3m<'>+Vs\V5޻OHT o:+doc#ו].T1[ Q4e&Dq.#_DCt)H0q%O#Z׆h_uU"hōrN0USb :1l+T{BsꐯI(_1|_7/!*MAՅ,Pw,;R)pfDbI/澙) wZ0+0AћO+>СbU&O^|XH$hw%꾕/G20_< ٳ=ͮSK8*YM p,ӠQ7!ZF5=p,72Sr5(ʲ2VޮG5Y&m͸ULQ2-_2]{"R;_mVCIa[垲pmd?ڬyfYemۥa#v`Yg}YѪ#5>ɳ%/#E 4cor&-'շkdEceTc j ?x(f" l~E{sWWuKͯn/'}=u<)a[q+ʙ437V6O\ l Fl?ɽ% i@&Q& l|d̪Pxa/އXb4X þmDb/ʜ@0l^2޵n揇 ~.\Vȧl՚!j#&0p\ty~k|'QW U+oϥ?_=:үUaaЋHyxz;yalێ{DfB3𙷎%u}\ 5ZyBrD)|^떴f6-qSf<5~ FYA%`NGx:]Ҿ75 Jd6e,HST A/\yCGꆖg )HaD'N b֤\/ݡ{G'YAv@Ϧ*+ }tC|.sW-.sKS06ofS)ݾ6]Z2&ӆNۜXa0&^6+Yk,.o&8Ș j|]jwB,xV؆Mn9k›rra/4mzs=KFto3+3ax%Zb4հV4ώjMfKM2 1P*"yٍ-g͖d5GAm8o^`ƺdq۠Ϝ µICv+JwȔyśq$ \:і蕓ZI} |Y}ORۜ|-b-+;d[p}n>=)cW+N g8E)( /oXN.g^**DaW|>f> q{6&۔gܒgYU·|E 4h׷0S40tҭ1QnݼsN- :tB`iôJ*MG4,39ejUR社)_K)]¯+psn(#\UKF2%݌qNsȢRȡUD:u߉$Ja"a/OJJܽ׵rb`vj;ѪlV:??b$~W;zz1Fy;[MJ&'HnZYp6/%Ɏ](H}(h"f1@˲;KDμFLKlР:Ѯy Zh͹R03d̼6fo'mAm1|sGl3H'~&8cyC oeNb_}KVL(&yhb|A$f%buz 6ä;=kDFz,Nc#}ȧȐRq]!v ?fWf4t3ipzrr*QcUUzEO4oη4֎`' h~)<ߥVvm\0yqXP}}ʼn)XQbh7^=WSyqkuYB,͈ lw>p"j pQ}J2Vbm!,m2QMMkc RF}Š$ٺ),1X X(u(`k4gG%(`)ã 6;j(OhPGkϵl %l,lDs|TJ7g>|b|lS􏏧OL4I!%@7CzؘA'cJbJk[#kS\]G"zS*o[ݩVv @OFQ.,xaj:.bR_9P!]Ȱ4 O#bX #7RKJiR\[ IB1QǐnzDP< I֐Ѱqfow]=tEIHL)4PϫŪvRrVM.MS4b$@8mdWmi\J??r4dmf2vKN=__\Pw:cd;dd=5Ŧ:Xͱ~&@'VZBp)z!i4D3bi)2ljs`o`d!_Zeiev%)g/|LH$]5E(NhV ')1R\A%a\egm: }5~IM ){\瞌~oɆ{9-,e/oʻ{BOBff m"Um?So+aFd?CesU*_O*W-[E`Wt>r gJPpЧP O*Ce K,(Sy8t 7{BBcpHylCwPCy#8zA엯w ;YFXy?ư4UQK.z% {:ьCD9X&'PzNhpZke|qu6&r] DOb|*Gs;S'\v_/ZEGs}[.Yw+WxeeJ"/P]}qrp|SVZVV]B!uTmc"YrEBhlƻH,X ny'['+({ ||W.=q;"?M γ[6o1&}o{s2@0cC ܋.l`#$${5اRaȄ޽]ȼgL1E r1d<:%s#~LǕKw,^@%(jhCu"a'㿿̕I@qdsA4+}SXhJ5Qw%9 їD^xƮILCla^3X!$6o=woO Q5^lVm{㡦ƪe V3l)[g:byʲ:ݠX&6r9(5c^$po[>8M ,m¡jV50b$}[ (Q urm= }O2<jὬPGĭW@ΝJ&iؑ+`FT%tk 9ԈUK:)HvBhB; ht$>ZβE_&IvFuqmU@oQDkj?כ0=wM/.V= l㌓7_(p9$9|z: 7ޢ?a MAF>x+y:]PՉ3/smc`b\-ǶWmnM4nPj~4*;^23SOdYdiSE6jo*jj}8.+2iKpϿpi+j hҜLQ\CǢHU||0c*0jsAn3bG9?2 Uuw5z]b .46=E~% %R~׿|5E>,=kryU>6qX3U ޒ% -kPwUaʴg_N_u:6W@eBBurK_+ r } ɄXTa ,Ϟk,^2{5Ԁ R `WϪ<94;R2ω}E(7x>f\g$VӺjW;BQ%9v"_ڄF^^DkzGu$8~3Mo=ga ͜3[aV|RܷWz\!>,d8qjC6&qs",DY,VZROj~Xyuh{2x'[QQi6cc ,ͷ0@NhjsgMx'|_g/ZG (YS (TvU\>BR(sY[Ɔ}PñU]QU{a3iw]y̓/L"~t)bdiV~q~<{;՞Ý_+.0s>H.|X$ٙLmچ .( %q] *~y2 U[rR@,Ő遞zj7rpYyanl$ԙ`.aVv $<2=֗a+6@UWe"@RqMQQ"|JXuhoǎ=\esRma. LF󘪐?{p&[Dov7QwSnNLB3J>0;އR6 y^ki SHpsX#U=q38<џk2=!lZ mg0xEqU&hmV(}@,^OS:Lx͐`J/^{y woҒ[P>QT&}Aw <{μӜLjЍu"{yN)Te)}Ô{S$ųӋ='9]۬"[ZexB *5eZ7R-}븜݃d$v] AU6_0㖬dncme gA vu8]f:Võit^!YzXގ C9 ZP[efX@<-?{T_(s$}CdWrn)ri,) p(fdjkZ&C&`12\`\\z3 FFIY.: S߬w*$;D J-f%V kt`[6]w*B9h4f+So j WUB%WӷϺgJrddz\yL.h\WҬvn;$՛h]oA_H?&, D p*;Nsz' b1րݮU?Byl]Ǫ>+ %zO8eld spI[ `n㾋UyrhtwDOsE(oPd""CD֓0<=O>>(Ju#ElCیT-nI VsKqloO')9}@/:h fa)/ǹ$ku@ 6յdvYBkUJUVs -eMA68q#L:yOcpUE3my.;%xpzAX$&PME 37mf| f=l^EͳN}T划4$~c/00QͿ]͞4nz NN|-35Ps єsͬ 9>5qyCZ(cVow˞ 60KA o5Ӑ]٬t SIc6>?t_jK"`j05:3ýGQ<߯T_{݁ Y˝'^vs[}[Kj<_B9<2ɑ$ǡUQ<ZDo2\ DdE5]mb;4rSU^'* qWO_OKI/)L*wiΉai_HUx$kS1f;'/oI׿)oQə\͙{a*]~< ӳ`}.0z΁=h`.f$Z1Y55y%D% r_elX~bL:KHhP] (J1ZK o`({/ ihNkҙrO2 yM (@9;z21GApn0L.jN@B^ϣ}+_ :q5nCS=`@Hbt&zX[Z|h`ZEβ(H$uua?n0n#s K|*j4/a$kϖ?Oy4|FyhF$ =;#Lvrq'bs lF EݦU2 diȩZzB 0򵛩 zt={ΰʏx?!ۼ6Fs2w([_5~?$nU5>}hC{u::Xm/%LYZNl$FaSr 0>.Nz_3eԓK%#TKy,$\e](W~Dz]4)˥)*4owWgݫAģܴ<˖zaS ~:?5]JK;XLv{.Yyj ~"OB\wkоވ+<y.ArKբY廑Quz&EMrjl>BuDЪZi4ΈOL4A_o435o=N$ģZ-|uڳn1v8Wl*U >Ġ'BƳHgݴĒҤJi4Y+.xSL*>)A;Vl +;hS[aJd eݶZ}kt$نPOkjD|pҨ9=73? v:W;Ȫn cNnT?3)с?߿f$ 0n@bwόFϏ8x_KA[HKa:[o7MRFܓVH w-wͥbDE~[3jg*~x-d{ۅ anv+ /IbX%@wEmK{dYWmw!Y1A(&lN9?Ùۧ0)L]`V%Y:1?i|ܑE`2&SYZq,ĭz4$l`1^FgWL]lLMqcI ـF'peZ&)sr1(@&`t|JY1q~ za1/Ҁĺ=H~Tvi]ٌZjw@[RRZs*ђ,,E6R@ T$g5_~NֽcڢiC(fw^x$^M ա!=;@f ntV@@%ۡwTfid0NoI/ 3]4.r Ŀ?Dy;Xzz/Ȗ;!#f} O{\N-p`-b_85Ւf @ҹ6&jar] ݂;pq$>{L{c5`/|Pv^Red~>iuT9g}u=29ePkW"i,]}M` rCj*fVco~~wZQ}TjS|K9U~CuqZ~~{xP51ٌ2,*ZjҶf'8d[(+uE2RuJ<;)xe1]kx@*Co捎*f /K (K[(sݢRqyiA5)ba\8ɉubG5>>_+ dP*.) 0!\t}zD}9syǔP5c \ZkBmzh{ln(0gM0^ evXWכtRy{C'4*MSa>`mdϑ;P,~e➋2=Ƃ+ze^1_OQ}WӕS`LjJ6ʦuXP˘:٢&a2eT ]HRO|o櫴rp{tԾf6OXh2T戤P]lH᜻jɲds7P> !@ăDțI$I!ĝtZǟAwGDxjZ.m]SŘJai Ov.{Ysy~.W:,j'yt2riDP v z g͕|+$F/"#] PQfО^j)q.I 0>y;xY>kFm.TS }Ansn~KR{'+T?4*YwVh=s`}mMKJ '᳥P2xOzJ{_PaLEPQ+"&ld>"y]/Xq|gz f%ĎFQe"ȤvZ_]5i% iA` SdA}^JRO5aA6ܣʺd?PLKEz>a8jaaC>L3tіpZO[(gr$l +‹pW)y'p)]Ғ?xҖ.tƥf|ό S|q>xAζБ-'$vhIYe+xB(0 @!O`5VRZ~-ܑ"+~jz$ra2TeTa#/N6@*K;#To %**#g{X5(uHynDI'Nokd'"9#C LEw+;Kfåw@σ#Jr]Ո=`E甌e9~VaY~1 dVegy״rɐɋNzT'ȘƗwQjeK[NjZD+".F\h]64ulYʀ 7AQk٣$6ZW2 CDBjD1}NEL#}4>bqc.x_f! ,~rL:伀G3QL# !M}n;D.9ab M$&r<}ki6g-Hk+[t=ni}Bܨa>GEAZSbC7[q6}=_|b& O"w~ϋڴ'7mdnTj"*/F>Gu_U⚿^k*O47UDFErQؔ1( n/rwryҸ0FFB3q(hU qWW:߾̩^iDٯXjAĴ_ž{/@θlެդ*zkfӕr'Hi»I)U=3|э2nl:;9?]?Oi?k :t&Ƨ:P*IAQ) W[#JٜifrW| peҮ5R$Q`CֶyKcMuTWSN)8-jdj)r[Dkژ%|u vp_Б_4yЌ*.L)+L#>O]d[dalrp>2T"닧մtP*3: Um\bLfBO*ܬqʟŲdH(YoJ*"S_JYCOnTt"Pܴoc)n2c:ئIq.:t..DϤ{paM!o,JOF; ]GPtdLZԄ^ (U\wki܉\-vKI"]%Z(n5T|e9kSٸB$ B+!>{ f5\,A;Ǘ\k|.$A XbB5k]3T{lnJ]/(uV%$ZIbw5p:K lJic;n7TV:]W’ԺW;7_ņct%WLȚXYN=Jm犴 z!3+SpGlЉUFS`Ά.VQ[6pM(e7ϲjV,𥹟L} *.& 1y`"Ԇ깮K0@V[b}纠ҩY؝8}& `=׍@e/+lи4~l6~1HRɖ4bѲ~+{$yUť統?;ѡ!gf|Qjnk5 7f*A5Tp/fAc ;\%ĆTdebaߗLlZ_5=֝9SlOQewXkdg'q?M 2{aaO^AUĺΰpsS||P:NlHR 5 \. Xux&XV3Qg'p+&ZFIOwDzW(}bHs`'2G@FMlJ]{`gLX6l;&baM*IqN(ޔդ_3OʪdRPlޓ<I)F^|ЧFy-dLk?(^3(&ц;Oy'2?! I LcRČ;Ʋ?OX3X-*b\d&P8 |bjt[:b[.y]zPug"W;S(4N,PR8?;%EEMz!/6> neN.d S։J~E {I :ҁ`J͔d@ϐivukM+A$%@Y߹cmJ>PkV5i MأX ޣXYo`f9=UA?COҡ$4 SrYv.c`:4@ ^?j債OcYlY<"n #LSr]HH[<#PhP=gMmI$ Urd= el,(.xU&GІxgkٶ24vTL-4.B"T-u\8QM22Е\e@P&Z} 5d]LG:%ݯC6Բ')GJ\3F kYNk6JUH*_SZ<uGK:jוK/ Գ w[>*WH..3yRgzv+G':*keQ9!|Փsu*Fzyad,*\jqԧ e*DaڸR[_%TDdzf܍ŀ9=CNKNSk <|wh[?} _̗rƪݬwS:gGR}0rn4v֤ +`КS5%ֱ4^y8@6<2i1^zJU24HrJ7`6K<:K 9DzHn4 Θ.ٚ{5̩l[Px[UV%"k_Q/@L TO)p40vo:rORSrGT)d)X;鹟fCr$akŃ>,OG@gsJau]{֙䲦qB,< $s$A>H>NU8Emx;" jې80ʡO)5PJ?"zNHЃܩigf@$?S# v㤨U\ eKs=aǒ$ѩ:#X:&h$〉cBw)XSuŸ~o^F!o\Xwx'U IύLCb<ܸ0%lAEG\f3P$뒥Sk* wV'zvdXm)dZPUKۧuE&@_hp#z+T-ܧ@kόu Hhdo;T5-SC%I1֯zl߇eB>yܷSqVHt)OUhP3xU%[JHV>- -B#Ze-n߄5))5Dr|cID';B"RA>-ԁDoW'g_wBpkH_qTSe%'F~;##4"qd։Vr)Ӑ5G~EAb{8(ovkHZc}^K%AS GG%Oarjb<tdLPjZ1>Sn-"gb ԒtrR$ Pt*İXLv kMUZLwN 'w qE[ Jz4e VsKO##,P.xʜ _ UuG'D滂Ŋu6%Me/r$׺( n5%T_2J6.JZ٫c4'h(ٯΖ+kaJcI5H'y]Ccg\lƽ~*nnrOpnHOʩMBNɔؽڡƐ(Z1rP,)M&vC-|'=l>6@p '"9 9 dt*=hUVE@KF`P/,QL;U} į;"^/kIK,( \UM7}$\c0ȧyU>Vit =to ĩa܊V Uv_w"QiP]E]+/]0NJO%%2.$‰A#՚H ˂",W݆ņZ؝]w"hPjPA(PD3K4@zAՅ z FuqzX|4 Y59ʲ(W_ af̈́%ׁp[A FO ^v{IO˶9F͖!nIf:uP1U"BUD]B@Thˣw=ލωpC*OVߣ[ƩlVwE=b-ڈx7cD Rۑܓʋ"FH쮢-<՞ȡzR##>kd-yG|x2P$hRi9*dqDȸP:~b(+=-Ғe1.TˉqHe`;vnvV׈U8p}/{ r>. ǵUl<58O+'NTo90c&lQ7b3 nk{\qj)`zݘeiߐE<7J2=L_Hz/F&]y]Q89֑[g-꩸ AIĂfieWXkV!B8ȯӝ9x.kFK+ke~f+60Փs!+lӋT̔+!v?[;ܹ%XH98"A@2l&ޏI$ dޗw/SO_C/[$FY/ 6!(Ӎ) bذ`jԃh `@[y5Q4UL{ڬ6Ly M<WfrL͵$- i DSn-xe3 J<3{(ɴ5"AK ke5d7z]R&=@{}Τa v|U))-iH*$[wM{>z#2yRiA瞩/znamۨADzm Fo& oCL0a2߾/CzyĐ#gUyPнe$YbϪ"-ymQE1ۀoA^;Ko[T]׬ }v8caGcPBѤa~ddD6E!%*eN+(̍V V6Eunhq#t0.i~@y]x{!6}LG49vmɍ0S2]XuRc[{n{=Yպlh!K-eTu ,W (+A̗E|wP+`Mr|)wj1!+ 49siKBr|b;#|{ ODuG_Br{8n՟uϔbyhLqcwSM1kh SP鉷֯ ,_k:hT})4OI=tW H1e#4`&U\Ím ϥ@:CGgl#REC =*>]*@72 p&Mށe@gH^Rѕgx >]aFA`RJ[1xߞCksy)Wzfnc3DA7vҍ(+i)MHZ ]e.s[9 C[Ӛ g)dKY9P؞wżԵn.!%i0-0t\x hPO諒ig/47ڻ+jUSAGDb]Xo3s.=ϰ!KD~I}!- +{ų̴]vV^# [GEӌk;;jԦ ú27U<#9WK2FjMb4c*H4 =>]6w^G{760-{Y8S7= ,ہޑNm-o}훨I_cP۴6t}4w,LS7qk9tVq3͸Lѿ3YMg^}=\_ o R\x"իhԪuӘAI+A`nn*!B'&Rj$Ast_exc[N@"yXT i<*ebY"#Aar>_kX PkrR5 7W[ÒaG9oSHJnF`|2<2ݽ!)_S}bF{(nd GPDr(x|<rZ9IP& BkcXc:CziujZkrN:.EψB @$m7+kdƯw~[dλqU`<3IF.| Kҁ"VCeyV2 IXɼ|8:E̵X 4u 6Zg^UBqB9H9 Roio5%v(9S R!~gB5QsAPz4l=CQ 6,N:cXA>wlSoؔn$'G' (Fʁ/hAÅ4$iN6e28H-gfz0RLJ?k?s0QT!0N'H?7m aYw1Q20H]"Ǐ~cI0t+#ႊg1:*)B~=KV[uJw7p60>$oqIi_vXA}r1M2c[W8mQ?k+jQ׊Wٚ6$[u䫾Sc-r`kgy6MA|\ 6^<Oomaaǯ6~qC}oy[=z䌲S8jq~m5\ 6 wJo 럹\Su]b !K8|ϞEX`V/Pgʭv谺,p1 8(\|GN͏o/rimf՝毝gYFkk7h fm;ם rS  ^..b/Q/P̬]l{$D Kןd}=/=2o{Fu#x /:lU.7r\ +KIT::mRt!VM%5Sn+]N~bP<)K})~=d֍H[\Exz,J?:>[gl.Zb%DzQXv'¤FXm ZFQylV@{@]W߂N@GcVc* Fr^ǟrR8E w)aѪukc|bdkJqI>Acf~ԫ} X~t izTihRW1N'yZl[0mx6-̀Kۻ[K+Z O}˸<݁E(on̋L˺+lr2v_6}km> ]!s%j#w3j5g -@?. o;OVi='l;~n#H'%oZr(n{0c% Osʥ3O׋PÓMM ja&w<+MJSm"Q)m*&1X.} @"C"[NgO _ܴEf5eDqqs*>p=] DHyaL2{.-(H0 rM>4ĵb1쾭tUV_!&TϤ7y?qc1 YU}ev_)4#|\F7rٽMVЦ)Z^-޶#3?mP}_)T`K[$ص(E TvM #Ss0.fA~Ο*:LɇWi*qPdСd.XCh30o h7E3mm.]ASj#ڎWXNȾ㒋lP6`zhW;U5A@X.p/Ș6@^TC?%C751? Aȼ<` >j|7Cw~7DW,W=~g4rLfxҰ3 Ska #н =vcpf}>Eb LΊԉLX]_uD\ug_V3~[GlK7D= 4(_/*-xiflM R|:4,ZZl@PwWbyaw }S*>3Оx04^cmúź*4!,qvV$$5LgX)gZяv 8FЪsrqiU (}N)cWg:G5߬ 렀riE0ۮ&Ý9bbT.?x5Ұ_fEϡ7&5H;܍> n9|m,0mv^i~w/EKg-E<+] Y8iӒ:qKIڶ>B"B:;栄Nʷ ui(#Jkwtȫ lď]WF1C[*.Dvݔ`.$L #gW' %*HU]ZwPsɻA[4T,2u\PlX'Ј蔴UzIC8q)u@U%hiKI8wq)z qO;?^xJ禞bs%[)WF!b24mœz/\Ii]>:L kA 8V<= rMO-{K^T["tDȳߑLK#ҶǑLʑS7~+-2ӕOW櫙P])0"<Mb\jmMT;T{`W z@{kK&nB6lPHaxįpp&{F ;&fe I0~E4bL/rnEP??0q䭒+hdiq}I0z.NJ ®茾Ht@Ӓl2¸ႂey&d܃8^A cmqyF.TET*&>彍:Jo0=uJ8UN^ =@dR¸H ĹL.T٣)KUcħkƍy(ybILmMۍki;/Kg)[oOv Ԉn.eޗqPbq̐r8"gf.֘8eWɓ}~so +CU~z#Ra]Aa>oOR:;ڌ?mK<*}UdK׿tK׿tϡQv팙|3>L/3s+ N|9_~v2_9qN"gIE20G*$Ód۝04BuĿ2e04$ӓƍ I*l {ڦk\I1,ZX_[ѻuB챡CKקH!UTD cּey{$}W4BL"P1ҵ;(/__βne&"'$LsB) X,|7o9n3qQQ~. &IQr0( }FqP<詋bugj("38 sraݳ ;=¡|(YN*( ILbT]{y__ھs`@g0 +rE#2\Wq@|ת 2E!-)gɚѰ3!]vʱʳb $ai#؀/A^` eT  o41Lx:&eo%PF c@bjJ+ G8KZd+i<B.|C)BƶT}l܌ȹgBN/}g`|[] ʶi+ l9+`SDZ'#ˊhfKD"rJGkiWXڌUW.d Dn03ihW\IjHX` X%3]>~hCՁe%&]͢-Hv^/-^d`kgP@G {GM ?,piWF0KqLcPo>Y#xyA8±vejHiYh4c`Jº6VR&GMs>I4+hBq4j$tu< ӴݘT@;T"W=i(ҘO7jyAwn2z'u5h籥cLr+ z]@</7Œ_-z#1Y""5$fPh[OQ /^61|fUb&2%kp(dj@iu!ڧ( xY}>ۦ8in\ӥ8-yQ812.4/KfeB&oTNH׫=J5A..c5Ltbh1R1ۦ{va0եOduDbL=@x{(I5f҅Zkx ĘrQP%%c75y|7tNiQy")fU]7є݇NZܤz:7aC'@6V<.NĨԳm-.$F[.7p.8]xոZ lTYvSvpY O*]2H!;qh= Ĝ m%f^&=_"3y%cc[QFUanOe7 pRơJQZGiQYLhǓf>ʔ9 lʌ@/ǩ&Y଺ ^Zl_(ږQlJݳ~K-a7Sv÷`H[E T%9_*J(W 0I wv"/)spJ"ː=05z~Nh hp^7r̲0SW,ղi+q8_bTCf3X{%y ?f >Nś zG@*AZO+d@Q# BMU2hIWKș=4)]cӃrcTG̮Dg}#к?dVc$]:oy۪+JyJUɠ2@<:tR#BjG6#P>QËn2!2fxxW(we!3<5/iej55W#ZsqΎ P-/K\z)hыW)(s~M;R,:8&Ij6i5Ki3ſ~0 (x)3 R` aal75 ߴxiۺYRx3.bAM ^;;UuXXj%JT)= okQyaGN0sqL6&rIáwrR'TCPϰ4P;&Uc܀ jlzJ = YMӢ Kq$BW{L ٱ̱XoĨMR X ȋBX4CnX|o2ޙi-HܨHws'iұO=&8\ߞ S! )&1)6ZgRk dY?#(~ %n4yN|51!5Yhe#@25ڧ5j4y3@ _%V9$!>] X/(ƾ5(9b3>TO֏r pY>~| ?p[B]pE%|)@BvI5\ML4a,X[Y9 *st.W9PxތWƏ<ٗ;}Kd@!@yB;,!^cֻˈ~V~ԲF(:p{}c4;7I%@>825iZ$1Xb/=<f`JFa30,_ G6[9 0e14ǵyi{*+5_ 9[q͢nh"41okՅVf؟[+n>|f$pir#J\3Yڙ@q;OǦ?d`~Ow [}9':\/<ɘŪ4,2(c=w7~7/el!O󞝞OiE?pR2BzQ(I9vȮGn3']Z<)d{Ǯk};ÿ>ևeHv#n]N$QuM0I053ՖT9f:eE7,'8Ps a!&gNW*_ぃZ˰a~5Kvm7-tQH*h-)BűϫM/-zΗVt/"OX8M 2-Me ԭ}CQs[^sQ5d6-&yiՍ0tP2AкbU1& m!%n?Lk6{ =@+`w+ 6|,{jΗ}I{{FXm/3njLQuӔ(P}ItV@~.+IOդ &.=(YQQκAuz<ՏiM@ Y ˜7~Q%Ld 4o9>oZۨL+QaA fRڧ8Mլwl#D^KY(KFE;Fr5|:@ #wvX$|-OκA(gwf'5aArQ+fP$E:"^,<zQRf|!AJ%Y#pvuU q` 0'8_K u+!|^D1~f_Xvzv#ّ#ATSHþmZ`+sa*#? K@ KZkh+e5} $Qε RF!? /Ldjfçŕ.\{M_u1Wu> "ˋ-i3Lf%(gH% {w_L^_Grxs9ycTŋ_ Iѫ916u{K}8Z^&9`쉋 wlh oG̨#_X ߊoZ_;>wG#=yCܒ7yjLN7ONd^D8;룠~ &,͏N *TH8#VJItk-oab `[wx5:tL:8)aВQ@dzc8lW:h=oVa–rfl2z Ƈ=NV>9A_jW u05{|~XDnj®,sdjUݶdTVzYZh!%wWD'g!*>@dAK=@4(3wT4=OyXlSu"]&{b`ĨJh kw$Do4Qm jWpq 鼑LԯeA.tfP: Yh@=jT&:#аzA_I_ 2`@A:g б}H]%}E]_s&@yo'L&GE}٧H.t+tQn1Qă9B+n,ateT큽.o30t.ט끝_ zkޮpd=a^T %( yY"ͩP9hL74kRMmf&^ߚ8pּ<3[駒cjD RU`84d!Ӫ)G' X|R՛*s-y<]rͣ]_B_? 9%Ƨd=?\ܾl6N 31i g*} R4 e+bHl!5]B=N\di (ZBIjnB YYDvݮjG2|Ǩig/m՗I{WX=},37O ֺ^ѠU#0z2I5L\zKѠsV:S{qpM~ 0[YTͣO:ztmYLC@޶Aǣށ\_k,9bw3`0#޳#"v_nJfez $ M;~Wd@ ZCqZLD{iوފWKj4Ua>^<ύ}l_6|BYPEwst͞j`Ú n%Zoc?G#D4hs#. EKRM&(k~rN+,k{nܻ`:$#%MSjCWPYARpkݮ>OS Ԏ*2d%yFD?'#E3_q S^UhΤ5SB󼟦vp-8WFӅṥͮ"[h`Kd)E絊@!'5ѹ=6I&~=JxR:?k :^԰9x"ruwDa7tTJ<-z3נR?/✋9:! j pM|sTPrTéǔ|>oY9ZlDډ"$rAɫxt /NG:MDS1 QG-S< /x):a"! y#YI券CYuFsSY0޽BoK༅n/MPc\uUMU7uSoe؟LDi8 lY̒/504c gWx EvK2 | *gGMa7#KkD0e›' 66yol \2T9&Iat8Qܽ!%{`?Dbm'I?m}=Ҩrܗk"vSJY~w~<dQOΉUF@4Tc|PupU4^%-M$?xSߧ hC0⒠Dy$cdܗHr9Y, ׺ߙ`85($o= e`13g scK~nO_$J(|TuK+.EgW,#ɹ펹={OmZdz-[ؖVYZA|N$n萧CoΏ7,D,׃<@YC/jwM-0^!j%T{=$j󭷎ye^GvhZ2c拌LR%bS jMBD<$$2 qČdeRq0 R YEq l! ѥ}ޤM4R/(xGގ4K@^^#Aq 6LHT,bHҬ5"4DxFd:٧o3թ=Rcui4;c*/j)A(laSU _㸔u LQHۉz擨ohe8D Up{srq/uxL]CLLok٢?]̯gv-e G%Ja &d\g:s6">4OФ"PpGIG!﯃BLë 6`ԌrKC1*TRLr]:\EF ޥՆ6Ne'7'ڮUzt73SI&XЀ$JOQ)7%dbrjLK=tJTNș)mpZ'HJ`{[bG=% Z-[x!;{L<Cf) Ź<.!KoFm`.Зj8Py=&A&8q=UǷUԊI_ &M'i.9lB>]J; P:x,(bZ`˔JMCѿ k!^y8qM%TىЙMpNAcd^B ɚO&VgAIZX`[#RHK@*dhPm!/OdbJ"5+u)?at SXfq gأkix%XK&ѷm=p~עbWCڠ] ZnG"/IذgTRˀ>Ó}-yhY!WK,|!Џk?!֊&DyHihʠeBV 68Gr2zW X 8[ɦ/U~?Rxέ]A[Ar &\5,y׿`=G-52ӛeb+UqHM+vnkh*Dk?-Aiqh\]sG NDщ`^ΉuYT6ȥtt=?*}ߌbOr-؂ 7[Ұ2\^3sx-ָ8KL)2).ڞ8mu1!! Tl$J6Ġ  )\jg; ÷`ڌk\||1":&I?=blP;*T>\:\Ixle#e@$aj)N\+yƣ&*q5(ܘ2W]- W>$r|;U{*VIY ucxӄRB@莝UdbiWz͘Q/_Jן#j-G=*;"}B(5tnɱ;]OJzNH1D q^L;zB!GpBC*Iʎݥ5KLXAK<.(x"L)6D"qm;!X)+]@"Z͟#fwdȱkQȕm+qO.g!xE$Qf̏9,v?1^3qԢ?' sxamLzxI[!ÅHZD|ކ'N`ףYPСurqgc+p6FbM8& @rGE^@pOߵ`%'rTշk09/"nJh<Ƽ+ EHZZcUωA$HY IO͏yz+7\-.ho\O1цm@)kD@;:&.#fOIE 6sWyc d,I$ ?M3:ΤoPЄ=Pެ>OR2#BլSȆ㩗bw+~z׋BJP Imfz&=3Zh_a,|Q*P<+Zܥ'E5滒o}j;׫ P!)$0QȐRCBFn41wdԼ)e7\BR916>F ʧmuUiUK<JVSxme`US)66-5U,a|ڀ+E Yh[IAnxs\5S-*yx׿`=ܺr->v5XlN($A鶆̠D:]r.Y:VBVj8W&ckRlax\Eޑ_&Ɏ:Uhs===`TϞ;šT/)6hn!io$=_\~a=evm8 I[!ST5ɠ|'dBxPGλ%8^*mfXE~';٘Q"Mk}Q8#/ ۷RSڠtCXMnRPC_kՕ ̺0-Ģue;!HpNUIchȞMVbﻸ`.u<I7Vȑsz 8~0UNE- iс"eD|A~[$_YG<9/_?|Zq (G׿/ ׶o;%Fgs0i}s|n[WͯK])ՕLII /tAl)E5v6Bʮ&g\.F?2OL N MJ(AMٕUpv g-ZS2̒1*MkՔlarLIϥ; 7獡BybW==1y5+y SG\IJx5n,M2~Cs uMN5"iq'~ISTHt):Ufo;*%`Wi/ʘ i(GvO^P!IQm:4ʣ soK8" 1Yy^!gb㞄Íh"Hwp)sS APNU7#MFouոq5Doe)[O"@K[_֗Cu)yd&9LLa>Q3 ;`Eiiz`r$' x6s1\=+”0^ ="hnc[0z!K" kT : ]L)YT]"QcV`T?ڭ~9] üيOoN=(m6]^w-[h;.b#-'ޜ6zXƵL59?Ϊuv~ø)YCs̏reݚݘ5%Hzu&Ֆ`&o$cWM9=76N꼩|w;ހ㇜3Ʌ|sr!դDUdRz9̅^RȠyAƖ$;U|WT br7k=6_`cr!]#.:KI5lXPF[.ajg-9 ԷI1kcɑc C%^+/(2hCΪc߄59 ]JSfԅ]RQ>X`WXT)츪Ia=6Nw fA h48M/7Yמ/-= -%l)NnTWp^+ӵg0d434Pi2hFY - 座/^膗Wku}|+qV/wˍח7xo*٭a .063RO)2O,P`A! zJ-@y_P橖&*=W򔇸bj79g}LY.&C/6is^]_Q_Q_Qs#YB[HGBnj8cf F+:S;|*)Ыcgn` K3"(l&LV 1?^i,FK ;0#>̉M6Xf*fmq`B0Ŋ!Tߊ!X-y#~x%k..}")3O0:xE.=uNoUCH d/6Ut.$(_~\)lU't qvK@pU`ŊBmcmg v|h/ЗBSgC A)01iJӊqeQcrp2{FY>7 0qQCk2$9$Xdc:!.9" N5"iq'~DISTNTSo?o PlW;FD^Cm";ؖ-`>spcj *[MZfK )ª"#_uEgK l6KZ3Si]r9-I𾤈~/C'K0 z;i[PNp! bN_ L}/r$0)k3-/ <3IH GH0ffyרi),9$GHu _uO{hb T)|kGS"zyŬH*2UT9V^=%V,>뻞HԮYnOty:,;k.OӾf}< ߷+\;$28+yQXˮ-VJ<תb>D? R;GhZZ1ٖ#q3%9u[ dFgt,}g@du7>=G  5$(.Zy w@+d(l=C+by$Ϯ_H~L /-ȉ|> e[ fڡb$n#YߑN4r5G+p뒦e|cVc6Ռw<8} {KV<ҭF9 ;6@>H)5?9D'l!/#¸ +l GiL`IvWVu&G&=wo!ح!KVXA,:f~d7wa~4O@V5m D0Ŷp|3*0PX*6& ¾owo-k -_!q!bd :L=ȅ\luda@`FMM#Zl;h9gf$|DK>y?*~$^|']9tkЌ=;c ֖ӱߔ҂k[i\'\|`樵.BKzJs•S}Kİ4,cI5ﱌe [==UޘI]׻ z*vؓ岬2Xe|tmNC3`(5`uMp<:o zyHP}mR\C7*m:,~TFi1g-ke{)Qb%%VdρFp>Ç߃ gK鏶( J\OhkXLs½zT#Ø1ahZCnv1"tGKL`}ߗMl0vnwh#o[`ͶKBu@]%?]P#:ӢĊg)s5mt^"O~yW5 vkOsH"ü-bsj\<7tRHA1]1}GqjJ um꺅XMIE2,7-Ho`ų{$zb's4Ԋ[5Bs ; =2D]/;*/zv;5Yo(ÎAqu_'V+d%}IHz%}Lɷܳ]0a4$JA`&8Dd7DLufR1}kηiCgcԃ׊ [)7HTyn!¿ 3GMgXz0Z,4F#:?VQΥt=i[zBա׽*JOTq?EW qry8;&l5u@H xs9F(jE+W|]jZʒ|{K@%zǛ 2ơ°I*]Q̀&V.j/jꜩI;k_Eg[ݱ %ϒF4r< 46SX4T3_)C%g$/wC xgދ)(wtVTfICF 5F[3{0:`{m5S`j@+ ttvDcOܤ{'ކ)jF7awкJS3$ @ƶH*G]~եb-?6K&"}HJR6c_{m*> lhUjG:aA4U'rj{_ԃ&bX<X(TUhɔ:+= ƻ2p|'! +#ްrz({^*g*=FR )7."2:+>s79Is&n8 lY*x*Ԧwk|pVY/TWAJ;93nsIFoԾ)!2L01C%7M]j OP$3N-M\9~LT-m5^Tph9<_t}g+++'<0KN);Qb꽸Gnw"?K7q{A8Εth)_"lt|_t>vnIiC֝Y8'^s$$]yؑ$dUs _#>CQ`|*`ix1ZZlPx+z+~CMV_G۱983+M RTK :,)k>G\@z2J\T3tg;*qnUI6HqmE+0*R"_ C";w6g]gnU ,.Ԝ?MFE9 Q+P,.\JF:3ys&&U-5Jl{]=xn !/uuj|ϯ詑CNm}Dc}2|.9Ӽ^Ѡ&/elM-0'kiIoAGO^LP Od@Y}BDǧk2&k2&k2#Yx7`w><9:H+tzy)ݰji !dk{]D;Nڂ^B4Z8crȺOnR<Wb4s &:XYiqfr\<wF '7iK7R/j9e'ƭ'U1d榬`n0&u)eW7x8q-ϔ5ɝ L2#7x+hrDPcV$vl|PV >냎2zi4nsIEoԾ)2D-01C%7Mj je`u{+"ُ)E-k C?w+έ___[Iv1wwxQ\kt8u':#2HzIߕ{|xOHݻrܟv;-A\'HI%T\+@%HxrqxiRͻ?P^7=Ix5jhP~.Z\P ^ ÀmP7'jH*_o!健h8K`ߐjp 0DjpsE3_7E$f"` q{@-QLMҜEi4jZɤԊ@q}wMK(knV=>a*^Fkk^B40(nAw^ bQO)Նx!)!3@nj 'zn=tA8CAs4SR)#ף̀kP]pDA̚4fl2tiOj֗m a a47z(fSZȽxr< oE+= o"&)/=<Mm8&5щz]:@Z 0x!yHl^ZlbX[9,`c.0LXOsf0?Ăù)m m މT?rӧ9}o[dmW D?J\^DߘŊ׆T_.98Jm ЊͬxިIB+QEF X¢Nj*wQU= %7zdHDgG륤ﹳ;lxRxY#UW>T`ZЃ':j(PJ3{ 49 : t\e+MŨd(lCgЉaK|@lVWн!: /-hYEc[(zz2bf< x []H1w!~=iOƈ*5A.e*$`-%}a&BN Ztr"[))r:p!@p`,$HuF[?m4%LԓNBͤW¿E+1tTX>q_'cTI,py%IJiwc, 셡#DDRz4k(?Ƥϕ/eX0 i#s+ e˫mU1<56䒩v]kN5vWXӸTW+wT5nZW=jpq^ǫgnQ_ 5:-ƀ3w\Sf<~(5V /vR%"Î @(^xw+ޮeIwnqSz֦K4 ýx+)"Ph!y#~1!̊~7Ef\GS_x=I?nys'Y)(>)v7!藜 #-q67Mv:Qa[K7Rb4w ;#8#s|F5Z-7JA\]z|Lsm76XE?}KLƧOFGiDyQ&v$NdJfij".vxJ "p'zeqPkkͬN9f6Χϐ:=1OT`+Ecox;BuH@bլjz+Pa>y.,MɳzN(Hj3͌^flYj߿'*jNt6y3z=m*?֯7[_TI` 0cC)п>^w5ҢzrXeVXoM>9z/7LAf2q!\'j̝z^d(pAz;eMo 8Q-z*ߴI*lz}d{}N ~b||ɽ?a~$pOश'8 <.R*a郾3\:! '=gYZnN5Ԁ$IJdW9ՄaK|zgU_ljΐ7"]kYŋ-~'@]ޣ)Uyj b{esktEJUk+ݡ% iU,k@iaGsdAjB/F˩qp'YT-]*Lh/]ڭr:ry q6OBXSr xTqK#4iC)sRa#RY(Rnt{ ZE_zitJrJ)R9/mSڟ~F+A*y8i4Z/)kߛB*z܌mh:hCYPOk#@ :0Y]W;Cz'5P7͐>J٩rooU<=["FP chT\z[l=ut937P6 4 ҹ\ dvfȯm!LoLB~ }9,/1Qu7/P[l4( L` W5Ps1bXuMMYڽAgk lo43Q1Yڙknv׎iykMrXͨ\|t?(ȓV>pq[Y P=Mi{櫥m^.5HQDSkof)+粥Btfx>M 1f`V*eA+ -n*23\!lܢv5iԁ ZuS O0c W?1VܯQ mDD&sZ`NRu=*ܬ="%*D܍hժdIS)F Ocl[O̎K-:GxQ ACnpmR l]@B|AsmRב/#Nɥ6\#0??~[a"kgP CXAެA5HQ]_dR jyvFlYoJ6&S3C#·ͮl MgDz8l d7t:c/Ncư1SzYw9X1nG,1]iEL}ݝw0;f\[$Fı"ā~r3!49Nߓke*-׻BxwUײ>/B|Vtf< ߭}yS]*[C%GU=rj5&"m"-EYb&hYӡaQqM3I_HI9-ZK[JPs~j0[^s I..EFB(NGb ѴdwώMz[vbMX00ȫmw [yϞ0{܅#1ތ<仙yy>83GoܮKY< Kf6l{ϫL<*)PTFnf9 Z20^э2Z*>q84)L؊!/`eL/(Rߤ'P8ބaQ+6 v[l^V~Z>(B' 96ep;]gk B)Hі3NJ*UH+3jeVTB=с5fNEۀfw5mM0v0xc_vJ 2 wZ" VPu.m+6)vXB(p/腻̇-js'n\ZW}vk}1M,6Uw^j\.҄ĵP9ϋQ b0L1uٿ2&":3g TLue;>n륕Tih$Jی2Jd_TS\pnNÏҼɚ}u6 gG tŸIQ$CJ{@=b٨'t-g1iꐐXT>_(n@*NUQ5+ GQ-@NH# U) :**eFWCw2!]37snnAhSkN\L~~P_$_`X[A_ϷcjWKznGFֵBȴAӃlz7qVB$qCQ~W%-]{JsסvBHB_0earAA>AW3M:sJ/)[<}'6Y38뱂yLޛ']X6֢{5#3g ͿϮ[%En͋(3a9?~)>RMVQam<-DTx̻1/jxsV&0p~=IjD =3AD.+5cxah H-jyN` +">yx'.0q<V\~uhԡ P%w;>b^j)dQ1#\vFH qS~6-_6PQ4C6X++`%Lo:~r1#-'zsyJ85>Rk%=lݦ07[pQD)5ءR7(:QK-^OJS#NN`1 {Q%b: S({J kzViƯp6-jAP`颉YǠ]aї#y.ToӴ,]nO֏j}_;*55aDp&uIw!#G0YT1Gv$C4:ΠnǪ'M7GKðXf -4Gfxu[b=vuw! Z;MQUʋ4N6 P6^5kɴ= lҌHĉj:m\Y->s[/LG55\Z0dZ] |uo閭ae.Q! 0H=2!c ~$G@t? )Yi9Ril6M`F 2X)2dߟPҖ_2jy .S,&lÒ+QP1噌i۴ dz4\~h\PD>GK]ޚ-X4d_.85ND*Q!#TA ]ٓ[/|=\-UO q_P kd(t八ejnMY6 v ;f&kMȜ^ zE\HKyx_(Ǫl} 5򰯕cߥ@ybB@Y>M oƊyu|QQsQҽfL^ݯV4  cmJ&2ORv'^$V G8o Oŗ|4 a vTر$ͨq''ϓ;^޴3ʼnk苓xR_q[ Nrq׾ndo4"S$?,Es\Ӯr&ClEcS:\1lmYQ{ 9cbWP@XƊEmk\NbXb{]XwDvhzf+)e.X cwg @G>aK?{)Suߔ.ψLxsŁZI.)t_g?&#H=i8dzd\RT{%`P2oͦA$NLja՝44k L^Z:( 񐔩mY OjV*kj65YqŜ,||HW rfNXĻj-B^t)1摶]0wg<#:o5NhÈj2>P z2 ŗ{GG w Ϧ=IID\A(,"[Ij܇UJHP5.圵MÕ^Ƭ_:גЗ G=Faﻝŕx4!}RD'%d'WνxN~_@en"]Pe P%j;\LɽG(V޻zT.O LV@VSM֝ ªȳ0ăЪE-@v7݈Ħ50*0QV>Ø~zF6d2|@aKNa=1$~ִo[=zH/L12 6Hy*Y,Cӳ#K#fj?4pzN=|K2WZ@o&ʯr"3ѭQ*U߫XG8 ձ f~:a̞\ R睎q%3M˞nddJvw" "rH  QS&eG,mG혦%Y"0ryV+Ҁڠwivhıպކ6"_K !l[*cBfcO ÅŅAg[.O̅}]Gt9o,+\Fʬ2a΢$[,[3~Z~̆ PW `&h_95am"]y@i'MRբ&\/]%1$P}%`.߿&^;=!w?fZ%U9|&E ԀQW]g}UR^;Ne l9/-rI@,كPHT6fx&T95__UԻA6 ~ +oS*LT{W5fZ`)Gi*ɯ.)(;9-,|8kNwDjtͩGYkGBbDxd1V7YQFI6>|M/Hkk UI`e7fA]2r'9R%""v9oH ~@=/N+ ORV_ ߛϬ(st0*m4ޓq)֮_HLj g6[{P˕댕 X|l҃޿|%*yT5S{najݱhdou@O飩.].VW,S _KE@'q՚3>n],ֽƆ ,xgvH Iہ3tn4qxܼ*jªv& WN'g!î뿯V~ C!3G5Ge~_Z;ڻg:sDV2c )`So;Fzq+QrǢZtTi\-بS5%ɣ*(m"2=tbbCe|~jCBiĞlnhۺÑQeiԄl-{U, 1D1]WBg+aPS! T- UJU]LWݠl G@$LV~{v:Vs²zq@|{(d5&WH\&]إ 5jg<Ӓ{ruR9Ty9~m79\;|ۡ2aZ$LyYZertm ]̪ #!Ĵ6.S~1и5djp}Neځ.Rae 0-:cvw+W 8X8Ms/&KJ%qRN r ޗ7|՜04 t)SZV?/+;8N9])d'ՐQ)\;愤N0I/|EGֿ( f '$YܣUJT/p0޹cO.#Eoc߅ Cr'!cXѡDb-ޣ2-j\$<yUM:uͦ6kRfgNq%2f^dyZ1'.JWZBj7ڠ'[zZܘXS߼9;#a0="Я--ˈgAkn!VZ]k0HuAn>RbYcTΣnӦBGN'/i"+P6{G`9;Ltb2O*p>_Ȓph:q{*Ao՝ e՚K1_ʴ-)D_Q~'X5&}ŽhZ8Qc+G`ɩ*x+ٚd>E[7q9G99o"96'0[wםZ(Ny1l65wNN8Q=ɏϞЩhŔPf0yߋ2?B_n :.!<Vz!N{ϑ%V|\I,s[C# YŠJ ,9h`)"<=U@dQG^ #tx%/<%\dwkVggi~8U7jm'#Lue5j:F-t>Wwǔ*KJNJ``.+?@}S7j5=Bs hP-=X_JkM *%kN2-9+=*AlkFd_k%ҡ6 hEKb*@ |YV-ZPm$D"MM Oczd- ¶blZhLS"?3$+_-OL^rAF]IsIDt`o,r;V}\"ȳ5FkvMM>GK3;JxA'{,S:-f% )*j 4{=xUP(^m(A+v,vSj~_݆2zi5a#$ (3y@lb_L0t1Pӗp9:#Q.wsaW{5LS'S#Sjc/:5vUJ)+h\4ec33Edj!,#=I߸MKUt+"5H/90Vv/4^@1VnD@mKmg`qϦGwO^Q4cD(ʄDK{\;{&?hesU'~ QыPM"mWkBRy,&)|uURiF^3!0t3uXb)rȇ56$Et"akp5vP|CT a_*e__G:| '%ΐR*!GՄz*N.ajz_N󄿨*94E?@AvfF<A)iePٔ 0%60j+tQq&G KYҴt)eWCӰvON+:>3} cdٴs"1ȌB-\72quI 'b!.V'żA('i:ؓPi;׺8U[BnSUO}au<~_*ȼ t?~ӪJI؝TyХNTe?NԂ6dR3b' /a-YdC9p}*)c~8eJ$Bmu&5"҉bh;b$!vFV'GgXZZ0v%]HY@m|uJA'CsX.]ִeL*vUq`[_-ys_[ፖ>E$ לPR Xp EYzcp1uo[RuݫXIpcE(r{ HY<:أ3'#uV.|IlTA} [Z- ʲS2EZ65izN %Q ֍SIk.\ ׾f~e@ˊb ǧq8( f^uQP:VF&tt T{r +؀ va#4x[W&hoŎd3^`Mq_ +[ғU|+YO8;{hJۭWbO^ƒ Ҥ~kzLKTKUA&p(@+ğ, *&?i:%dT *ѵ=IF*Mw+T4kRMv:oJXbhꏟbhB6\r:&XM*/Zrԭ*TۖkcyC&70Vܻ~Ʋi0*!e0YJ8=(5Rn|!f` >[`K~CSF0\,;_nN0͠ M4x:)y(pxE5[C ~e%4ZgNL,Jj_vdqZ8~^țgDYUjo$3EbA9T) FaO0|k)#]2#`S :a'BNMͤ }&ozvV-ur!};toAS ,»m B$dSAk`IxѴm "ak| Y NGs䦡еyﾾ~opjBY<8-_4_vU']D6C7XZ 5730J R xuk,jkzrH埨͆ѤGoJrDYh[!i#,U.dل~-aLᵍ:}M_wjփ F%yu8~NK0^Ld<0P)2kb'SEdH SIMz:'o=u=|}tRN= dFYd /"#BYbo~K Qh&y\,HGkߞ1|:$lVb[;ro w~ѺQ }~R R@GTTj?VsAk9pRgh[C'j-Ed('s"'M^ (8"DH,#aD&}oEB I| Z; O& S<\д7N‚ :5.B]3 RLF~aKnlg%!^Vw~ߐ1!UTkr[Y-WJgً#llQZO- oޛh;S4q.njW&8ULL)<-ܱrǥ6yHx!<#tԪГ,Sߺg<+Cͳ[(.򽽤!8! $z_Zؑ#CM_n: >p߅slZS7nӎhJ@=廢m=fT,h,d*:3&nQoy 3Cd22oϞNPc⌯tkC4VH.|#g{*Qm^Ӕ]rc (5M?@-ðs:$)Muj(S!Q?߹U^9siNcJBs>JH}ȣO둢uoxqz$Om'Fnr0!K5 ڃr{-P][]-Js-wY਎_^^w ,vyazM,6mQ%}pK4B5Ze˯L˝Cҿr*sQ$ \uɬջrf`vHYDѺQb'ZBSe72X>"(g^SCXwK7 Mk . </6잻')CrGU3f/֙i<7?B6L@x1b*] }hEƹ5 ]S9N5q* A}־4 ]hJ$ œZsMf,xzI#ס gW@ɂmFBt;4bLhV_کX<WP1a(xNZ!۳iNf-'A<Ys i2GiZ+Ҡ$yLtIrQ~{)QEm&xzbnĩ:mߋ~ b5t9mmnpkwd &&5ʁhz `906ʨ+EҖ)<!~*|_t&ކ^S O M|8Qْ+j2q(5KSmNs !>u&ߠ 5=4;f&Fýb7Smm3#` LFy FF'_Qu/JnnEhA='IV'ݤ.Lr᪁!nZ8O?׎:i*3>R&3y uG(_`>[| z7Wԥ-$1#I89z1D؞ g_ۂvϖt@֍&,S *r+<2 yGT›~gSne] M\eLR%%hKZk 4tKlLvCM̼$aong;PE {%rċHfG^wC΍;F8u"[YoNA|({^E@y3nYXL%-zoFq-/-6гue\) !<_TvkOIi0sxt*8$5iDK+-5 c˸rP7) \Rd01kςjAVS& u=|=Jt^YsZ,s:P*swi7>V$}J+r #1ėe ZMa *mԧ!S\b1 m^)#-e{uEpR&9cu~ph%=ߩW4*[a L_B3j3X {vjL;49C,O!6IGBnfDjgZ36,CQWchVl0gzV.:j9G9ؐuI=.P %_Xxc-l4蹃} ^gn R+œn.f|W?{ Қq.78 z)*[IW&JՊ;u.[/t >YqA?:( C*X-Փ굍qφRWiUZ9@![g]i1? }"_!o*ݎu4/Qʗr>X=N[ƅ_(ɗ\"1k3)0UL$܌VaN VRW @nFnG~ \6%.o?fhV=3cp~~ x+0Y)FܿcF<CoQRIm{[gy+0e\#@t3ĨQ9{oSiة;+u=.~$֏l3RZ[Jߓ9 )bnf3/@GXfL)ߧ$Wb3l&V7rN;+*jO S֊gb?bd_f1~J+) XgƆ1$ǕftT70i&y`Csjn~;/P,i?lF{ϓ9B{7xFt'LM6@K gMVD^o5e`89؈(ŚWnFJj/!tN]eCOK)z]G F&|\w!&meTJS qpf[jL|^zxS/ַq;1ġp!j G]iS3(t/Vm$u3nF?9&ٚrz%,Σ $3i9^ 95Tf[Qe VpU^U Pէ7ғ:c Q@eHmjw o;3gY'.e0MgKnzeZx8[D~$R w[0d֫1܏I[p*MM_j>+6KZ6P\!lˠ'Duri0R)RYC V&(hh."R0vN]ĸq'8r#[Skv?s:4WI9/PIyjERDڮj_S0^!!I1b=jYTz5&Z9yη||r=T=xIC@̧woxxOG'R&l  l=B߾oX,X㩶.} Fj p"G*VSzÚf0n&M`*;<JA+#MoV. 76_X`?̧]ڙ76uCr?(T%W,IDZDbb?Tm@w;EgPXN7Y8%F2E ઃ3};?d;K~V|K diϢ: 졺_ngRcKTٹ{ѓCelVA4m0EFqCx0x/2쁦Vx!g(`J2[sEԃk^j$({퐁zC0*tdisrL4‹/Œ{Q~J#Nv rq/sĜUC+S au+{Rę3\f+#ڹYޝo Ǡ{6I+DK;%L̘NiP4W-tgbRkm!Ӕ5JDŽ%qtu7E$E c"utf6ER 8X=8&DF/IV>KOyj f@#K:g*8_]SziU9vỗ)ȈVqdCU ( pubd@"[Br%)g% ,VQ &!^.R+e>,k:qt1Qը1u5Yq2PY~rAbD26Ja9jdzt]{ރ yRMvH8C/'^vY1AyýX$ӱMU!NTv;U52S1ӷ|^sh kDo+"N8+e, P5~Ԧ28NQNeh4`.ӥR8f'ՏRҟ:9k+#hz'x|X[2-V:_8V^Wv<|Y]Du5+axlazTFA`ߙZ*b`[E4#9w/4M)&܊ ~6XgWYl;_y&'lv@yDWÁ+bm6le+ìCu!GktvgɟѲ39`82*}TXd +(kd6+yt"?bEI59ӂqR"ڿ6*H<s0QՌOW'<I_63lצ #DBlJ;j{UJtR\<)&?t>X~.l^񓛟3SgL4]ҥQ+r y1=~JvJ/)-{9a]m=Nix[ֶ1ء%dyP^6 7oUN7`EX5/o3؊"P!8š`$fIҿ?5Zõ!viK[b1fl,m |(WLhk WE@,.# IƖ-0QfW>3nfj`NGd=a*JH`[4gr<-ٹpgYs\$_aJ;7^IZgʂkSH"F-uQN:"o*Q}wy.e_%]7s{,sa W&im7Kkyݓ~>gd$!^ VkJ}2Q|$?O.]JI$ }}dЭt scW#B6ojU*e ; y47H`wjץC\c!|̐P$Be 7O4lPHgeN AETͷ?!?EB}I8,` m 0X1b빉n/V̼2| 8x2*Ъ{w 5͸Yb -rH^Giv,^خ>OFD1e}\!{>PO'['&f"{|=$uN § NdI.oj2 YLTNԎJJYŮ^j6{ h1jZȾ"{*!jDYޝ.xw;Ed?O[ cBdܼ*%_{4|k+ȝfF;qKP~A#rMBi%0 p6:Rt:kce#E(ͤGm$=iW)%ǥN[V^{GO5u\8 ;Ye#\Fθ=U;ueZ׈dwK^nBlt[ߜN;R3g=3 ˵U_ ÜVbi ht\KIXd#:J:8]̡RdlV?Au:.[PT}-b"n%S̝P_7j[yNr9s)ǙZ+:X@k2gppZ`u(+LCWa#܎* ܖC ϞL=NqO"<6)t,Fd`ϨWӝg nSVE*6bLq+T:[xb9{z\-Йz9]Dm8J>G/|G'Q} 0c'Nnf`j΄= [!!"hy`&5; 2@⡯ dc#g@QjKNܻ2v=qBCJ :0W6SŰh=cX܈E'dAC3M˳/./I*/AznK>GI1Mt_Ehodx(G1lֳ- eFCOl3&HdL,DnwUQt(-T㽩1=IA,whaL 1gh+'#haSVTI|%i@R7uAi l-lJBWM)@dII+'dLWNb-}N<Ԧ/D[3q|`NؖzόQ<ˡ{p)+Шv- s_sYAҾ2H%^v_Z3 6ͩ3}.I@c}]ڛ.s躦`*\Y=Jt}4 /6unyC2sg|FymG #F7**NwE͍Ncy A09P[On~HwGZy/,dϳ)!C*Xd~WQQM:ߑjlzPΦHgeN AETͪͷ?ᇡi`'~5mL.LdjbweM4{̍~#duwC?^\aJAb%68Ym" YL[I^='*D:M{EBn^&_^ A!{I 6k{'FўQNwu%,վFQ&S ҆:5LNY@K&NyAEc@Պﳇw5$SN q C%T |!s Ƞcű r ]EdWeA`orMDqEq0s¸_ ~a=ƅ Dх]m?4}`AR홟}S,+TG>`ur9brO:k7,MdL΍P2V0|-ή/bNE<]KMU8;h5̢Bʳm>ºnnhiUIa[.# %r7U`3{0_z/Rhb)q뵌2D]1K})uc_.uw藒2wp gabKY%t$=cJ;N md[ sFQ$d.cME6)6;[ƚ-;76n|2 (Hg#ֱ6;!/^G]U%5啓h45NRuUնw0c;iL1g7jR>sF/*'3T& 9{Y˗]bFD zNe&`ӨKoR>y䓬> K;؆WwAq '`>5xHdԟ IFq" q"FX{@ {8JdKA:Lxr(II\%,|kz/"hPp5j* 'B;.)pB_ϸkB P_2<\!7'j $^?@bg]?je J)P?o\.tOPY;aQ rж4AHA!D&,}'a*=] 6eV{RP#6/]w~lB0^,9QE:պ `2tc' V^% RkHnjC0{9vJRPL+ Z _:Uȭ*qQk^ϱ""D&bA*h8еWwFawMBE 3ҧDyV>u1}N\̘T\S@tAdObU fc"ϓ%oLL҄i%I؞|o˖`09&ibι -iY*䑐.⽈Xv ,n=`w"G~GO?rhʹC"*c=<="+_9Ax09 "Ӹ:&Lt[Bde/r›>. 9ҽm hA $_!o5HLv\f<dPqSr8Q?WBx(i*VCV)Qhu*+bKHZڢv2^]= Vض*׊%0ZF/䦌Ȅ<͚lX%Ӵr[غ6upb}E'ԣA.dvLFڻ*y}>fK̃H/u9Q_2*:fbxbY(+>@aԚ#bg Ȱ/f%8J4mH_#j 89v9>6W^-@3P slɵ NhRQS{C)DnِDC˨qM]̻֩Ah~'XD%ì&sIQj_g'^x [.5|wf&zD(lD3"]SѶpRPXUT!_8*$n`dJsMɝ9YoSk:s*Y}%9Q/YjwUMq̋ ($8{[g}b^օc*Xߜ! t[YNN(%#a]glɆ}U$7_iHJt33\;$rL(F_Zhq ,)'%sN{:=ޱ:PxgLҥmr䕌5Lä,Su~0sG /fzMi)WR nmw͔pb_w>]k_"[j6NWin|.9n]3+GzI LQs"rϞJRmgScM]OS ͮ!CGS?CId».GYf$TUoQ#* &7([WUq"WS,Uڴi3䔈_x?;y׳\N,}(:B풞f>hú@RAP`+EE&1 C׽ ⴪h~65bgI7KڒF F ~`M/ 1tIidOGRrs*&܊g(J[`墂ŒK'rz\uXZM[T͸Tٗa'-E"$UnCl͆}#NP_B$k\5NB^Z2jϝ˦tsWR%Z+qݨ D﹞' 'CYN լ0C)jg6tD+}Kot :>[9(yزrʵ!KW~9> m2vdp+%bHnX6ć0f)hæg܊V UNHtA yi՗X/E3 fg`Ribv@hI|؁ O" | )8t p:Іfb-x\impDivM )S<@{A]=wgaZ Di*# 8+zM胆PIȹmԉ盲M[fE=;"]uʳ)hVo~&^B 纥{'v2I#ǡ^TFyڬM{(6CEa]Gkjz\j%sIrJ7kwiLBBGy>U˵ v{ ,uSNN9g{|Y{Q!9"|Jih)6d%Eӗ%){\(22tQ\Ye}ZAL;\$nԢ ˫q՚3 Y{ǒ XL6 I]K tInodi&zWjU%{=h0x/h Ep+azC_ɡR<)n% Awj%Cox%8P6?Rp!%bЛ CB%hl^7.c=O)Ce3tRyR'vGvBNZhs7D^E7 >6bw ~쥞 X"2qwR'?, ZL/''W.܊WϴIÎ~Y (T^S_*-H0T\_*.7]b;_RTErMW]DraD%{qGQۓ(?.2]07d!#c\vemjKi.*jJҡc)4s 9Fq*Ind;{)J+J e~s ܱ$Tفƣ *Au%iXVtEH dΪu#,t-ܢSf`$ F1kYDv' dJ.k62,hJd"[{Rwd+u@,"ĠGp—-^n3 yL RaVU>qh=ђ2eU35r:$]`uBԘ Kl%Wm:o?=?1";K@d̀ĕ,IH]m\N՜l~h6jqzsxBtVS}BֳmEwC D@og=lDV*b(nBVC%W{gTL4oo5Iq"ׂӆrkM~ncR*7jՔ3~,(J`3 '4n{7oRHi`z$v3ʌ0ugdj}[V7!8v~-mڥ[Nd/Z8ۻP6-V!1m {2F*8hXRA)>BxPDA[J\p0Ra>4=iV HM ~jvЕ7FF9.Uqs$+b=DתK'[4ڛa\ gτ '?r̎cz|f9SЁmHUު5R,N6 7

Uy]+5y0kJ,عۨe3!i'/ NC-hCYs08unLX5kz(BF:beΡ8 K.aeQWS4X{?>3)AB0 f:A?ZQ???oDx.[;53]b vgHsq6XldIJ=[JLrQ7'i5%]тsy2fȺyUϢyy aj@G r~YQdZ g~B2*7Ӵ3̶ЉoPQk\^seS 'M:jc0[ uTӰGJxzt ?r#w>r#w>rXrrt_T&K?,9630rjbcHX9gë'mnaD@jh]Lrn|nFͤ,!a@E;6VH2Ek:S!4!^ߺϹ)H^\ZQ=UCZ_rSY=4_?XJG6/NfTtTX@xtj`Kw~ fᾌ9g*W`M\Ɩ:vG2{y|k5u#|PdS-󺱛MO,!@;&eOc = )T&20 'eM/*%7?]M6/8 6`E0Y)~9dz.Iȩ񍗉)hSAyP+5ϙvsࠫ  bU؂t9 LFE 0VͧBKՊςvX tnG9z0Dl')%SM1Aă<62P4Q tV[CC-=W 5ա id2Xh>*9leL,^Ȼ@*z7D%e&߱ŝIV(2w\BUܔ]Wl9}7sdhV ٟZZU#I+ʱI PN}l-բbCoPX1LHK O4Hh\YXeD@8{y8G]^@.P@\b}ڻ(CQ,wDmXcp&]?_s8|#βlaQ3؁j3S_w򍒂%uZ}h.R,=ob1ޗfB~@jMviRwpyd;wK(E PF JNeXT)F۳~9P|8Ș1G9Q$sP%.;+)Y5\cs0+u%oSb⭲)ZQŏ#W+ʕXt#AQN<㘛I;IT_bXkg#&{P#IGSAɷpܖtAAa:4]%98>p[t^(C.)ڟrq{ArT_Qe.1|?H-9xZ.@$%Z&via=DӄfDŽ㸂ؾ-tBSr#4=ުm32w PKQ3%ГvT>RBow%3PƤݯq[;pNxYteO9n)|5P)t1zO2E`8{C}ݐ l\M9&VmqJ` z7g!_H`H5_'G61J3ǜ25 jrX=[4HS +&$BQ8,*ꚪvyJy_ȈQ~YЯ 1ڽ렺g&kx4?gf=Nhr @ГUbzgTeVCVŕԮI}lJ%0Ikۄ%-}MҽV}"i* 3 ʲ[f7Azѧ"3 9X^AO 8V{gV,ut$Mt 9 Բg; MK3ruaffa%EK1Ag!+CJZtsm :/߹\jc6#_}!sXЫVg 1'W;B{3B`[ZX|NSz6yj<'B mW(ϼGZW-"m pW+7 SK,Id\fQPGLך&>X kCn.Nć?bl^r "rZt+]1q"-z 6곯{7HA%(sT5KT^O*ŗ](~Zp&YE[/B;q5c)Y)npXwhh*)UfVHJ WgT-ڽ,.`1d èW9W#=OKv˕u#z" `^pԣr@[P./ B(Y~x .1>TvR|2 blp&˞{/)YvL?>sr\yC-`miEG4Ʊ*n+ji. nuiVZфS.fpuf OJR&/[.uS,OoAhXOGZB3!ޱa'gfQ3UY8G xfY4VVW x,lAW/JWD{a{MMvE])cP+Kd_\tp& PZ?V|TbÈ04_#=5c]1򢴈;ĸ(el)0P7U0U/A2WT )ҔEm ,u&,M35Biѐ<ȎgD-C^㭐%ڿqoߘJ*h"Qe"eml..Ff{+bc13WJ_Ϸ|vᜉ 򲽷Ss{~f?MA si8/Ue7Cso@r=N:;@*[G$;9Rl Qo.wֲcΎ%T"̒E'ԜA4nqCѵHV>8OrA G)U{~8W4@"RWoTd<ZqІPFv:Vw.j|3ϐ BU#I{+GTq8aRَXG;L RB Zyi&dX6Ӱג4t$?6R-w囊A:\9Bx814^G:Z̉j0Êo?5܄:wY}xHZVgu%X<@ʢOgb4Q^%_?0l1k1.z|1,R$6+t9\\:/&:#Rs&z;No@? n5ǭ9_:kZh7BN<ڔ`{j>(cI%S8T"#hdgߍ6B&֭gf^gEhϷwbIN! I7f,uM[JcaNDokbP+[)C\:+[IDV0goQR>TkfEģy8;};eKOD".%P֐xTڞ:D3+p )GbeZq+XC,!4kqxɽ%~gVE@pm[[qs=N{P^^"Y~:<;_*~쯽5Fϑs*No&m\=wrS~ѐɉ%ڑ JYU:A\sݽRt36+%Cx$Vh(VӥWNIG!Pi|B72Z=_d:)ρc'1z^&)Be xU )^[!APK c8\R/L(L^9x44OZB|MtF6X}yQ7UF b?e>=do߅إ:nEU?g>ui@g8S|ntgKu NU-gʉunRb,tKʃNvnvMkjTQM( l6;\یT8cTnC`.Rna JklӻWp8}שu{\lsVJez#Vn{Boز;:I#IӥrH׊ 8Mkki㎎ hh)WE%!& eH[нjvX3X>^}"SBU$O^D~];ۮfesy AJҮT =J$tJuvio`3/rqXopWELL2gĹ6@I5L 5%RX{d N4$.8r6xIϮv2N2{]ۑT~6V -*= gS`6w^ ܣ$mgOhhTI<jét+B~টć2v )~> yGm$s:ˊG1 *$x{0k0u6nFvvu$vAQ$pe^;D8 c_{{py4ىk*E 2GL VݩN?^IrgKKܑě3^ƀE::Sgq 79B64Txs,nlcvKvm4%N'XkFDV[Zk"'r}/ii%|--o:t#J_XI=X9Q'[Ԭ"]\<)=ٞtX)]\]1]VA7{R^.5GPf&B.@2KT6D\j̠*)s~(ze)E.Yj.~j[agC$5*ѝF{kF_ђsjjBHl~ʕϵ+tF> N?EU ;q[ľ9]f y_![?m#t!k Y>Jbb,&5Q測s" T䶹я7 B*0q_ SQFm>(:BJ#He6QQ\ )mrwV䧣S<9!h R3ٵR[bc/U|!mg\3cu>=̝bP{5y(ɯqsv\# d_q*9$U/E+c,ky DVeI0f})+"->ԷllSQcSjq<>*{a˖xIR>ۀ';Zd,Y~"cJECC@rvFwOQ479ByD#8w|Mc1ѴzF'ׇK17B.VD w8\u T~H('>%P\AuxT e!0f(#xҏ FMo9B\/Je!siSziT< ]ycӭ ]k6Ua; dzM$_YՅ^k%!/0ke?z,kYR&.f7$p)IC&KZJxc,nt`Pj齮2T@1/6T՚YLVujeH0p@lLnn:GұDp¯$E;.<$]nSݸ\Fy0 -M~YWЃsQX˺8##B`hf Kj"9cA1n<"XhoT~OGXsd˒"<ҍ2+$U{%MǫR2MPMόL\ ?UnRF5i526C4CⵦD*k(9*%Z-BWB'G< 0Ϩ?V) z~8%ֹ"g۳Dh#~?Q_)G9P:Κat?aWiDEkvsxVm^ ˉɝcw/l#+׹͸*:5ƙ P$R"Z Fig7v.{JnŃBJReɋhw7Jg0`n #`BJx#t ~ll-%W;Xo42mءgl2 \mmhd7 BTb[vm0fjEP'aPuh+** !aTe(ӈcrnڊ }HEl-MwF-I$cU`69HYV{"PPUE1c^֗IMr g{-w/[kB Y_ҭ69[&~ڭc6H?:?::.G;f IH;)b>:M|ڻ%5Wef믷X_o[}O<5$ٺ3K<K ijHtpnfduJ~6! 6-MU\*d\EK$gTYUr4Q5_IR܍$ԱXRoUucϒHS*X^PJ*iM@f -߳ڱR\5:73<Ҵ-V@*U O2KDIjy}RL}EjQ>֗8W4 j,]3%VIL0]c֍yʷ Q/ ,kL~O9 `#v(HdMIFl С8]x#)oVK"͎|o;G8x>8bEgt+CKVv?"aFhM.}¡4VTS[+΀=L.MjeąVwcsiY/=s?e2lʷ abhb( L:Wb,9=Lbv90T|К-8VޙemC ERQ/,l{ӕz+9tzFem#)B:T1aJ`c3`P5L !"<:˥Z?b"2MWې41 [9qcɽ"[STqm)W1('醘 n6&_vkv )ՅRfQ==gi'm݉oyTi0 &u=? )/_jF`MQ6'6,.&si I4dv(B .o&<[(Ӟxw(դ],$.V՝-WP5.?#WYxaBjY 2y2_ NT>`,c2ϔR?SgJR{e!9ڻ#c WFɢlUeWzɩD迢VȺpZmhP dwefR/Vk{hjmKISs n=gQHJ KΜ į@jfڈc=V\xx$whѶ֙Ê7Q->ˉRH1O,2;Ȕ6isSiOBY&bb^/qCR'ҤH<|z:vEi70 MV̓3Ol7 )rL>Ÿ{JhVڙ:lQy$lz{yW4mlkO1mxm{9ea<;r5|QMdӘqI[uTdNsxxux琇୧̑Uh#s<Q9=oo= D R9WI߿{xq@ x᎝Z`gy8FɑΤ}hmC91yU~o8?9.;*+\nprscTRT_c{.7Oi[s1(:~iG'R1d|3VcԌt=IM$gJdh<|fP{&ʹ { uja =H,H}96=q"\jؚuL -fqcS/$M}#IhM ОM?^?/?ﯗ 6#3fh sQ4 t4>^{痟+#,͕ QVg쁟~Xqo{ ]lsi$jHq%V~ $zەE1niT4 iF@E_ of OZiڷvyu#.pB0U@^\E_|=Z7r Q5h1>>`nLD]|k*dr I<cl*ZA$\X*J6'`8x9E -E,`(uH%G zoOPő͔FLbp.>tgKi<UU\Kd@˶`[ "%BDq)Rkź1oeXˬg2|Q#gc$,eWDm䇄][8&ENk;2cG%Q -̑AEN$VV֕hxMЇ7`Py>L&-<7:C\EU c (-=:e.MbӥH9 .463k=? (.yhƝA{q&0*55<4 )^ s^ab Pp3V}<(TOf$_ }vk!iƈn *1sF>;l,8'i576'UF̙T7Yӵ ;ιThUdtuCe(}+1L.,+H1e6"|BŌX5ŽUD;9$pYI$LUc; *|1IG% cPFCje\xJJ9iPP$$ٍI1L=nE)&dDރSHn۔THc߇ 3 OªҘb=nn\J/@EB:hf0a/d]DZt뮁x I gRRPuJ!8jUjHE'_LUq &c)7(EҲɅp/3ui16ֹQFDPޛU1pH@Z۪ʩFXU$EGjI2V+Hv؂ ..M^0cd,!ܠNX `/ {4Gr:6!j^0(bO@H#h*:]=pۈtf%:YcJnFb5mUd3WM`O- ɍm_d' yc65nIlFiLegҢDјZa.1uWhDi,6ik k՘yH@<<ڮ[uߠJ6txHP57)lg,ɒ+E;>$+#xeE1t'qeAF :澰klH;T+Z]1=`>{%AV aRv:bzZ+/U 8.qIU9-)7 ~"8lgCYlĴxJX8Q#ƥ iC·PK C%0 $㐗-˂S2l(!>/JP>@뺿.7BwZqVCd*2SmLaiގysib³Yl Q!Y)*-)xY4B"U`H\Q 3?2HDnͫ" şw*D6H3.^%)8DXo5-'&`!Cϣ1ܗŇ֜V'6 ¤I%>5kO 4)<9@&YXˁ=qLoAZFLC^gz]bAL7~mד }`yUc0tg@?[(q#mfccC)5ΐ7Z »јU ̷&锫nEa$.L;fM7<R,5+4 zJT~դI;E_mfsX̩<Ԧ g,]H %I:o.^`@̩~"RXvL2WAfa|4ݿ^thkHCteqdO7+ǎlnB a-&~=yؗ%s;ڦm|Q#~7R4XO{r{V=Mb5yxJ@V;|٨DVC1ɗNm54Z8j zk 4<Oe`z.i+j&m !Ϝd By禿W{2_Paza ؔ+Nkd-ں5ˈwTj#h_˽c751-4ni{Hgr&=b)ĻUhm1oϘ! % :#o*7mGoϺ8%:[R:Z& ! nF \Zss:jEE>jh5w@2Dl3^So'嘓溜WpoCG{c1k[,9PssTs%y>E&(hѸ5vF<8[Q|o_i28d\ XckR7iRU:^Hfك1 Q$/<tAϠ]>rXdWX#y82DL= TBJlP̕ta"4,L9VJ"=q}RlJaJfk<BO$susCnM!Q <0Q1&b^H h>Z9ާqye\ bRdHNRFTy)88-c&6GTX#i|b$x#}{$Hz,u-2[|T P?(GeMb3Nsf' $>z+ ALkNҺ䙳M L7XӃUŬ֍#}@.N PsE7:Yn";nj CpKF qRs1d6RX~cYǭT#IqsD]-R;Z#~ ]+`Ja7yf)EM绲f5mtY%d]2kjYi >pV!f"h?kKV)d)r1~UpHPc[c6B} |0`"x:\ko&3̏TNŸCaYFmOn ؐ,{ۨ*]C7|r  5! pq2W+$TNZk1}Q {,M U$&S5eqO1&"iZc]6GYLgh6 _e4ͻ*yq.FXHpM?l㼣#F5M/P('x ;Iq@s5S[{gj(h[tB9,=U| x[po5+PTD\Z*BfV]gؠYjyN횰p{p ;DK)n ⏋9͈.,,o0e>:vrd{LbGpV& [HA@1J' X`.xYckĮ"I.)728׳rp:pJhl~hpV95c@-tDyh",hՐϞ%`Ѡ[K6tsA|YN= :ǜ/u|iNN=8TbڪE`qѿT6,"qg2cÆsy=z1tѨup,S3"xM@9 1L7 <=dZMJ%mx:r UCYS:zPsE Eo!fjV`KTu%zP_nMlEο*Gei^6QV&GDCEt3#)׭9Zqf,y?le(I+V| /kܷV#MG g`-~јf{Yh x5,$| qݲ9ؔF'2 OvDl]ekU-bJt§%ˆ9mC[kJI5=sX֍G6M#; OK _u.M7!)>^)Rn15iR0a[Tqdӿ 2Vߴf{kqT+ԄK jqRT0;e ܜf `+aOdNO,Z927GѸ`aŦ-9=Ge4!jHUZ;;^)_`FzϻJv;T䩻D\F mZj5̈́R ²dJiprO@Uޫ.:i]2)|R)6JqѶcuZpt Qy6$W†XU]i{9/M-/ڄD{,Zb |+%JJi<ӰRpsUiґYhT|;l;dž:{@KAc3lu|W?x:Htw5OgKx`\2;Ǧ..ټiyLHI:7lm/\& Ab!+inNnFHE|1ǤZړr;<B]+Wp2EP s| Fc|V %9y|\klcŰx -.bgvy~y)q]16lYw=ndIM[%K1_xɊ; |D{f_jit;zU=W\|<*5͡ ᡢ$VJ4Z3g:=0@icH 4 x ,< ab"C9m*X7HC7ZGf38no'U.ۜuWN~7ѹ4Z.\Mu!M`Tn rW` II!j;]9s憒D , 2J~>+W k Γ.^-eV5,aenhg8u-`תu|Bc<浬5:f!C|lTX7NvV|gѭzy;z%1g~OI߹#h"ʠ2c (䃠I k^WۈD;ǮE)HE[P3a zThaP8f*w^񂅍S_:4TpWdY$Ujd4#5VfT[T}]*h"`03wXԪcAZD&{2=T=tO\caW< OkzMeI&;3ZjAgM_%4]–ahz j{jӴ ~Lg粅AjV1C=)*(;Գ:ITϕ2古Vk? |*<А羘l\NK*  7ϪUe2~:a&!04|@hGD!H߻웳tٍlɣ^Uʄ%ѭwmXՎ3%W w*|Ću}O -Idꘛ9ԶI&ӹ00YѨ'c{ǂ\oK9i4/IdޞN9Mݡu0/GBj8L2gq2,HU PS-7zAbk||duD.hI2X`IDR(Lj>#VOa2d"fğn!5}4zv@>T[@nYRNrvڕ V$|Tgh:(݃/ـ乯@*gKgL][*6 l!&+US2ԇIbTsGep:' ӄ3|^[淈\5@0py2]Cu k\>\Z?]՗vNs39+͂SQ  $H.Ǯt{{ދNXӀK+ '^N{}dwȇa2$ ^7Z%/#K6tCmls:  ɚ%,b(;։~W]7bYN:T"+E5!s}Lr&%_e{ \b2eW?"~nR8e`ӝ *0/R; 6_(Q%0JU#V17]Tr:^6DI!b8.oͺ^c)XN'k*5DTc c-9lX]FSpjjNV^y̹v r/ UbF2plå=hm*|txJ&ۮ¾}vXD86 "zacAHkdCeYA_U(V5Bԭ`&> @kUbFynX^, Or|{+N%iE!ܵ9QN"m_2Bn30w쿝C-㧥>S|@"/;V )*j,klhm/ CG4dQGt^%kNˤ),c2_x[kp(r'׊m XbhkSL[#~$~X}s}dܭ&(1#06Ϻ9 ϩqeU@eF D\xUXH=Y/Ni6Yj ިdyqm:uzXf6cG ohq(_d6*P {(_q,NBQdbTfv8 Y*pR<2i8q_"2[Pb2L bƇCVQ ZXt*sӵhrTU+ٛw*xgy 1me3f(Ny~j?"(?[ey[M?>xgcwebaZEJ^M$4.| U,f#oNgNsː/Ceȿ ÐUU;=z Sx@"@pJ(0j]& evnʸ3 )=om ձ_,If7u _p|m?̪4[/$k1HgY!qnCsSPkEHޝM8,< ٬&J2@Ԭ ϡYgy8@WߒiRbu@Zb0OlsYoz1a^}*lNHx5n(4$zFK{͎kqYq0w+pąPtnUъ5(#dAC)/.D#K7֚ަvui̒<c}i%$Bi%Q \N[KLu,/xʠƁ{ 4@xH1'_6mGIF05wpS꘭Mw&4(]ThvGEe?dzpA {4ghI|IL?ٙf]̎q>0 dvt>ۇ~oC>tTUYɻO>t?9H@FS^SRP3SܣM[ +3oLA[giI_(%0Twz_i-~V.A#ReoPǼ0Pp>,[Gƭ)opˇȰ4+tdhbbۂl9ZJv! :a"aB*DJ4a!I"P<(Fّ]"8(D2[Zq 5Aym g_NPvnٝ}DjJWh(j\ (oFFMd*UYU}N1ٺ`(%\C<)(Bu-K1nVFY&۞ՆhԃW?a9PELZ l99[?8ܤ5 |k!S7z$c;VnE4lME{Rњq\EosyܦQ&Վƭ9 bsi ]}͡|B"[yj+"Z!= ,Rfk6.nySo ;r񉆭V@L9\}h *3VN&ViU1+=YΉ~aq[|+506o`Nb-#rŬNK>GP#v^e:yљSQ9)Ap k&nQ6F5x;5:iY@l t.Wkk +nVaAm\5I%p5!OoK%ގ|μ3.|0{VX ܏ξ:nJ1]MY^PZQJ ]E_d;:8zǯل:r.y7鴰<S {ԄER-:2۽~K7- sTq.6#8#_nCyn3 6H{K'\}ܗ>iEķwN;?ﴶ3yvkީ4J?$$_M @K)ikN]Ͳc3[C nb5Tn wۆ~0Kw޵ t'Z/sj64hbrPRqx۲630n@'cI~Z][ĚToP#B/vܢD 2ĆJ5EӔ͍ ^㍩l_dZRDoesv*2ȹ69s3bڴגf>Tmاq+~y?DnQQNa'RxVJ_]uסUyXv|l`&<k@& [ka`$" % ?Xo<ֺetwh_cJ:k*(>ζN>"])`Oa9wTL''ڋ'&SKOckJ$ՎqoN,صywV?^j%lSƷ,/u/۰TZKIhwQ۟ CKק8_>P,zn/CcIThOp\a f§/\sn_"؊FVDfP{g!=,.. ^\H&USҞORaweZ9<Z^~*=qèؿ@Đ]qS Z= $ af:d?pUpX8YV{]lPFD垣9N0Һz(qWEI!g2:BAIPht%Izo9|i#3<^͔\]j f5n0l腠m H&T2^"Mȶ0{`O Ӻ_+W=#"7(]3B[b9,N<\z +,/np_[[ʽ*y S}Ò(5D1sŹL.^9&?Hx@ z-lR?&95^࠰4a]1t&w|F{bQY(5pRWדjz9gNJDKv[%aER>|sA?𿟨 Xdއ}si^!`o׻aT9R4'=S6xej06dKJGZ@oC8m?Yf@e$UU7.>:?i}:CJiTڵ k ]A2U.;{ĥRuR4ABV4tչtc]u fqfoܞ`)qjVë!Ϊ ň[؝ ˉK ɦerw8sƉ8 0З hdz5G%;̾{PoP̖!>gte $-WmL{>b/@?ۈ 3 m^F0Ra*V1Q e3dmWDVwJD'ɂTRnv 0) ABI:I>+,ug=_L(L`MآbBt8 <=vk ţVJ>D)((/I<7gOjI&yv6I6z<73 + 0=O1:N802NcDDYܘ=g|Wg|GƞP<ے:~j'-"vV 6ywP [WVgђ'#$uJ,HedN&HlBigz 8i“lzxhUư|v.ZZro1<-FzorJ+QRg{'cYPv z1SC uJ N5R4s;¢hT;n]*Xج7y0'v+|UQ_٘^bj YqN#2Y\N'wlѪ*l/+R杻k#JBv7.ۂo'O#OфMFlЄk?M?OOOzMyo:QYL !kp۹lWee;UUIQuk*_5cG{P4!˧>]:8\xzZsM%L?e%#ۮV͐2,hmb*-F9U'FpwE?V̙6ZҖy+e^ ĻJb $\^˪LKdZN=<(HߏT^n~$ð}NEg#v.0ŖG3UQBJg_Le\d6~8^ 2袓D1+׳Y%. TڅKǵA^)ݫHw[?AڗG2^M΀J\{xH!QZjyh T@iGMV*>% L49.W1.P`L;Ƹ`!f*ɍ( ^!㳌5I"hCjsI)TT\XYG1pb*(WE&KP'~/;fCX^0\Bv?0wyjMj N߭?chmzG{'('jmE"v`#SYXk/EDb9))!'0R\* -&vw(5jlۼ&kɈ3it|ղم 3n$7CZ46 jCC =9ʲU{B( 4pݮ{&~>H[BvINFV IkS}|7_U[ә g~s~5Ӥ{(~NJ*!j-|0FkR陻3<8'w.8wSI7߭uoH市gwz! qN$PZ2XTb ^ͶAUԇS"Tv3b/!M9pՒ8^\%Y`V7)3F'3,Q9mDV"G{ą[= ?(S9\Q!!6& 1|s  Njؗv~DD Kn opusSNW@mCuHkRJD]kJ]jJC9Y90~"f\Rk6fhdĴ |nwj1 3c=y-(2LZS@*.HDok{f+lO˔EBS9Ȗ7'2E%4 JT%lKJ6h󮩀)hLuc䩲k)$rJd :6@'s ,_ul?9:Ğ`Qe>B׏ߝ|'G3pr|~}3FW3Bs^ȏtE6zTuJװ<}g8='xym28q ߜBOsdu"Q, <00ΰxacX{{sz 2IGDD< eE9ԛW2hH ΣMMjewyu%柮SqZ 7t#߀v@bsҜjoU 7Pgs>fǍQ \hc:g? Rx_j %ȵK%JᲫHq`eUx@ x3U6<[wM̈.1L?}jl:*R. *X5M5;ec (Iß/l/b( qRޛ܈Bॡhzksy4{rRRHTyrc:g!uUbzqN%^0}efsNjR1)oN4 Vt[oOI{1zY]QkLVh7!qf#S]L,^7.Ѣb8*4H":'VzbG!e?؄̾޴KQ̢S !1UCpd,~X 74̰.{ n/K 8Wk }}JPɯcO\dDшw%gAh6cRS?,05^ʚn5hh>5]Lg%1{+C/a7uXF/q=(BI"6֦C^u0d$_G0X~rC8bP*5I[.!,7v4 `\HH?QsTec/4{'Ч1uzCNg)J1sn0O?]nϡ]G|ŮAF!jR;CDs%rhn#&lTH全kQ"8@eR^WFl;/k4VF 0 R:cX#4oy9lcĠ.|h?QYh^ņj|-, _Vt.XSMj~ Bm|,Ú mʎ}¢vHCU3NdBIhJ,QȐVk*6ifcyr/j328PM,piCؖ73ø!۬7zD9|y-IJkV!cbp, _`>#䨴.ڒhh0i֬<ˆ3Wyn:>uHhQ^纄Dauv[=%vm*9*4¦3K~*,G:pX+V+]Ψ 3i%.AfʠH wh4 O 6T M v$1odjHwXύ`95C m7/`!|fB[R|]L[4/hrH%f i9SΧf]-oi?L.в0ɰGJr ~ t>[ľVh8݊ղHx;͠҉j?jn7i3(d`g,V\tZb('TP3g ]nPx;}s*DX04ڭ"tSM#^Y),ҘvGj*)Q#i2ht"tU*WE_"8{&R^~VT%2׷(#TYQs8H,isiݴü+A ܾgr;Bgoۏ8/U|Kw4Z:X, LmK}^=^mCE;/b Sn˸b sY Fa[ O Of~`# o0͂?44|V/[e.-yW12UR4 vOalq a~j98BdH00zuӇ4Q&!BTN6~bt0]]l ,U~_x=?jQVݭ,pØ"ƏM'ndK7l|!=oU\:t2O&^ 1j8j@5+W(3n{k?ֻ2zT<`|3g,z$29&vSg`DJv&?WKDA;Vyz R&ͣ$0P\VR7>/?ѯuVzo(U]^~ j_io U{CO̥;EmpZ24!$X'ap7NEtG.;S{\-{rl\.Eg0M>F@l'= G<z13x+mp|R?W,O~L3*šr; mqlz7[mIDfd J sXpv4 پuP (E9qFG?C9XV t Ռ$˸˦[K.Ԡ|S1s's*IզS[ŷvB /qk1jdO([`kdD gDZ8.j4dTvlewFs]O=0 ǀ f>{Fi .g%]6 NU>X-hҭfui(ԑ@FA6E}VqU*U7Y~TO$:[_HrC(>Ԗ{,3moDM>lFJD5+cQS`^;l큉:ov`jxɼ!(l1q SC}3/۴zoRvZP`XXB̓/O}ȝYoI>s#"WiFww7qGL}۪[omտU?~zT:53s\0pʶJB30غ ﺄBj&-^zk=Rd1 _ ͇iS_:'ͥp\mR +ش44\=ܑ{X[uVZڇh曶%ur;wWV<.]мhiyD[$rSgLC'oM,E}}_Z%Vڢ#46Yt$ >O9&3[6mljj{;K`D0IgV)*`ⰛpQGuTpw$̬ 38vܴ6W>CxxsӸ㾮XL^TԂt'(r[lXs KDMٻ2?K:t% .Z2ۑ{3 *(KX0R8=[2t "i`=H7Q5h=T`T+:y? t4P]0ryH)1 +ڛ( .#;f~NTL(/M{ڄ:P pҫ&f^}x+fd4p ;r^Y$bY&L)W UzvI  ]QBț'5tbqE:]M;[3 딕lmeLr#ɕ SpShUEӞ93CR_# 6Vhʤ{Hw ȼpz#I@0v;;@VTodrǣЙ6Uf?{YZQnp2™s le)wem%{i3˂XÊ}~`V,Y ;H͒ plLUr$  eIGT8w`ښګ НM ." <@JY+j?]r5#i<"XASd\݀*g(xHaH%;cON䣏mMѐtfj aEKe2b9J6c5N ;#Ǭet&~lW?pVP^kdT}/W)lkX&=:1# :ul'׌w7u=8{'60<afm1V 3GBJTT:4bÂu)uN~Pa2C@xf'gKv; +ų#!"u4}*ӷcuuB [r5h#t6 θnB-RAY$<.QC5$)Ϋ5S@Z٭†5Yu1e]_7ٚAg`>9›޾F>b+-B[5 hK; yU^ƴS];/%Kσ3ȝX}q-i 9l.Gt IeM53M2DtFJӿ(uTkWoӜ tBhɮ$-g|p7 ;7\l˚͖FQaJ?vH+q4) d,-H]K5f淍 5I`{wk[=9ʹ0 ϷnKM8Wm6roony>4>ZSfd6rbVeNKyx9Be4+^5$5!0|-Rq|sr^s!Pt2ϾQԕ uLLD/J`*Az?vYu,؊>TK|b5evd^;a" (^"T( t.&2e C[ىfoFрDgS}}HUT, !ngT])W s![]ݶ}E64& PK7f9kBخe ^"U_5#R|f Ԏ4@.{ xv~?TeUbVr*V8WoϸqcQ?})s0*!8 B+3{ވ_%j*ԉՙM(FdKp%xE=@i9mY8SRK͆>w~E8綠[|y%ZKHbT;CuS^vg#ʍ Ŗ-rWWdN8=!i$7i^>F͑LEs@˾,'q4X=Gr!*T'$7R߰kz\ T2:L䣞AF]5T!,WwJ|@k|O+vN<a%t sGv(n)joDwꚠuhNqd|QǝWL4 yC'y};qZW_+ӆ,zw)CSk~;>zm;E6/(V!.>_̞x|7%z!ovݣϊNǞ8;GKsl;5Wgas oYw+&H_9bO$YvK'%n'bT8xCmzi 绨qǣN{eWd [2mEBJgB5&Zq+*Ac4M0%a-A}jgL׶9`ǣU^?;6;4<}:lfuN-$ܛ;-hSJ1 qֆM+N*P:~+4sB-A.'i'ƪ>NB<\Dԇf |e'XDZ([|8>Ye%PúJ4]NzpOhc!4lBaf+*G,35ϸ:<6{Gxd2 "35 ҹݲ,5i/C3 _Xy[RV+@s(ryfVlaS8=[] Lv>iZ ~8[йW+3TuuBWY ,7~RDFWb$3c\}%oǨ>Mk ׍Z|엊O^4Ұի baܹ)]daRa+u8*J`F|^];P}OKŐ.8涒NǥԽΓVǷ|oǬdR}`: nO3iiN-ְYt]A`ArZsVDZRR)ZZ8Jy?S=gId=/nY8Biܦs;7\%ʏ־R)y٭hKwؑ}.(JtF7s0"i\L=}(2>D_Zkk3LNekn{Ԉ1x~n̂场 d*DZFމYI0'X_USNsCG ZKYl AELmT̥:ʕ B,7~@ ӍKR%XRTMkgN>< C*e{t4봪iuz 2_t o*ZEٖ0Qu dY@:|>Ʃg%LQ%Ӊ֕gC޿P2b^zɩ: S(hy(GX[}CŅeSY@?n&X4Jf<"NgHEh?GrtzWފ=JFIjhӒPT.N3(=A>[# "qbګy1_q'g:ٛDw E~3ߤJsf!J-/zB/rG!UYv2bqВܝUNra,N:T^57TDLZTlrVqd6-tI+GKsVB>^y99F2ڮ4!VtZ>kJ LH(nj[ \UE_c ˢmcIhbƞtU2ɈsuB0S|>.66C$^rvq?Jxջ]fnU*JSW2{3'j(Ly ru`5}!݃/ 8WNk2_S2/~G$<JC9Ӂ3yCyMDŽvɕtbOTUt:}>+x!60U0p54[:jKWCLv˩G$~? [Q.^߈9FVMTۢA[H>\V ïPZAtͣo $.mB6"dN,=2 .\5N]VrA6o=%Y0sHK\ O5ZAF=$ŲՂV,o['.*?t>{ނL-AdRpTgc7ׯtl2x() }i AqDMPESB4(O\*#xw!6sw:GF%m:1uqPڷ(Zh?Bix$OPG#8an^!@|bgڷwbu&u糣8ғ k2Y7+e#SG:9ł ƳG嬻@T!vPͭPOh‰>8os' 5.cY5hm$O{:̯'+uqCEgl[7.H=dob﷖gkjƖx5n]V%r8ܥB΋<,>m [my 9 &K uBFt^c%A /)#&oӄ3Hu5!^0L@RyxUzab< ==yXh1t+s*Ȗ?B:G&݇?MX?#|/9)zQv8/%c-̼[RtaOԇC!1O2i7(;B(:Tgor&ܵnc?ri-<"N2k4SD &ᯘ196WD'8hm=J`1vF0F⏳CC:,d+2(ōZ?4YMHgtCmVovD)jdص\Wz#ėWhou@r%}-Df4fQ.'cFt_[Q%:; wHk ?%=p>7ʢsmTu͌RWI$_w$j,׉; ckk@#":!Wvm3 yn,FScMn57`]ِˎ,n(Gx&=,)'sO AF Vb,h!~# s jlߤt^[2'+I=o yV<@͠t<<n6s9.Q_3M$sh.zF8Mzϰu BKr;S*tmK W#4zU2:za[)C|u+hMH{#JJ͉fG^8FK&](mN3VY0dt&v6;,L+`8NunЧγݜ f"j.-F5{sks\} /~eD w'}_DQX 23ĸZŒ u&<+-\ԏ'k y9.&O5G3US*_Ͻ~[B5X-BGxr$RցM[qS!hpj`IWZOJ(%5+Ԩb,Vm6 dzlѴ^NsT4ebD+S3gXg7p_e:/ikdHKd"}^9$NG  LOvpPEN#! >=!!Xa2֘ilqQv套&K gXDO(Ml0eX*" Τo1RJdqU3Y :a!$FDzۗ7C:)Ay\LkW/,65?<^aZ_R.#+^;7.!vjЏUy Bj m_c?+kJUĦƠ}-#WB`\d:|/l_5*3ɠ5TFAZ.݌یdwZ=@.9A'gpAdrd1_b ,. :Am y]aے<}sc\lk(r k%/(s|R>|ֹw_OTætǂiRˑn ۗvWWφiHM\l(j 6-%9m[ y Opx@#5'w~tOr}zG;󰻠~-|Zwk@2 1=~b;JWR׉&3B7gxt[)BS:=G`cfIm@?" cR5 ge~;53Fyu#Nv^a$ƜeN<.̡m&;*ֹF@UmTh1pĈF{Kٗ4itc밼~NzdeN"?43ERs:l*>O#(40U]q;Fhl5/Iֽ⨅>t0Y$d<;OMEeh²r aQLΓŮLy+ӌ+tH,aQn황WogOZni'(Kh`f )ĊEA?ЎR8'+DĔiCFgK-֟[.ӳuu'of#8d!.GJZ-y[k5\Vk"Zڇ^L_{h(Ln_ @1sn^RfQF(B5ϰNڲdNJQ$>]pzC{Lxf6 棝UjL$ 7J\!Q^5mWS,wiʵe^C!3 &^T3_84x9Gi7s&ŷhk1( Zj9_2Db~i:uR+&%Zsbòܓ0|7B*S|sRݓTn1͒EvQ2kVzsk)(=fJX}K&byD-QQ gָY½(YUԠ*CQfIwYuuK^F0Q{ 6~J|.@P)cr3ڽ_4p:րer=.8VYJjZ<Ҝъ|Sa"p_' YC,g-ZU rmPE'響N'K*ߘ4z9F{iqPh}T*t#)b5EeڭNoa>Dym,lbU;}TPlK'5`݁mK4|o.醦Gd&W1{ ^#?(c:i>H;-BF T}y!X~{ Gm iJ61/bg5LLXcFv;hS>y(f5m;dRHof<%;+`۽iD~":A[rPQ(`PkH2UC ^2Fh7_'PKJ++9H0Kv_ȑ0,Sҏu?}@Ǜl誎,5 _,̽@B5 M Gɡ9Z9/h`>:"S6ʇ7fTyk|Ưyٛgoy'솯P# "چ7%srvK,J \dEapUP OofNqoN@簻&up?8SgKf$ Bx%G0ݒ都Y+/9QD"_Rpq';OUTX?Exf}ߗ27QTqf#u$ f:_Xo*pS(@{)j"& 䢵Yvm}7sv- o9\w%v"}zu*]0~!mQ-}In}.껯+Zexs͍77#1 9ɴlP| {bFGw4wXP34G3eᗚYuA׌G56^mYm)|ւ_˸9S0f+"QL1Q x?Wc\ 1+*rޱޮ5p9{3H\vKD,#{( s# M7Ɂ׸|q\A;Y|tdJTdZ$]kYK\ȝ]_LP+/ٜ)wzgQEc_d̩&s9WWEzCe!) Bg2 B?f*1.Q(KdPU.x\a`lүВ{mt4`D7_s Ÿ-g2 Js) VoCjGzPj9#9MsSY qt-<:uчܩx2F Hf$OƮ&2fy,["wRx& JA%m)Ț"eJH_~}BP&.z]$2 ^%qCN.sV{ dx&¶gs+N/y̖,GNkiO?МPMA aHw3PB2Pj&WktY "_FYH$vVHrY+`2E=qaLB$#A ]x3pOAC<4QT[KX%ח"Zxp*Td +vy泳&f>m v3]*xDS87 X&{7}bۨAkLaat(yٶbpU2YKp %zE%ﮊ|{ȴ;Sѷ:ΩLŸU/Y^z7?>qNB?8z"b GL 'JQEa[De"f]#]2FVrْÞZNr߲PpTAMZDX!|=ajP~ZBӣVNkM>$]L(JϷggO![ RJk0s5fuCmII$I;#ftIUQG|pZVj}HέofK8Y=MX}mN:QW'I>OP}FXkp,(][Mo :[o9\or]ˋ>涀~EVqPhG:Tk.i$- dBNZs]/Xt=q?T`Q]M6RXX);'V-7ץ.ujz*B胮y ~]|CeU˫<%~ZݯrLSiP.QfnkI:SrV=͘p>eQ fūRfݠz(<g+'uW-7TQk4Q+24Lfvpm 42N3 GU idgRgefv Dv[yjlӶJT2֛OwnFB5ei"VWY3!/66jɱR8{(L _CbI9 !5`jaT(5oJ"%U,mxBUnڤW7b;S'Dr^rmΆ$ uo^ISOvqY7xrI;PGٰJWmF?J#701?Tq~3Uׁ&e ~xq~=3>ic1"IY^ cZj@.2tICPyJvF"UlDa1gE˜L*I!ufK qcY.X7YQT?MJ4Xe٥u߶ZFCgmf=U+ڛ[ܨѮ+n>Y_Ǭ>CPMòZ˯^WBoyz e I-f\&Ř!ٯʴfv}͚X&֫Zon`sy Î6װ+T Zd2pP{tkm^<Dž:C@i>(aHs7fG )~4}+.©h?#_ܱN'i #v4R)gC!m$ ]am oY]ie,-oyA Xy6Xhn0ıgj _뭒}v4J|IT>^${P0"B Iy p"~u" 8=f­l-\VzvRc_{ĥ܄ݮ]},؃\\q!jYlyY;ޱŞX,])u3p8? & gH͕s8Ԉ3h%ZG;Qyjw.UxV"; ?sGn"Vb#UeSrnbm*"zK%{j$& 5M%WpA21֚={Uݟu-4N]qhᢘq!-{z'._1r53Ҙ7=p'vNN{Y͂ٯ3!1ZÄ\;VWx aDfɂ&#W\AV*]5iblMY#0C+6.I eijslV¨h^lZ13ljp `|fo]AwMR K@jMײ}tV;7pT Y L;YNQ(&}5m﫥ξÊ G[;+3517V :mq*soMrac ȁu$&UQG^4P ]*VC8 9(Ⱦ Y! XՖ?-Ė8U$hxhu x'.hU(o\>N+e&lO:!dVGב 5dx'՟읟ńkS`H+7 s>? $J0ino)4~"l DuO11|Jm{Vಅf;KcUlVg k;a0+ zxՖwlX] b23K[#)B.z>[[ {D1n7kN(wV| ƾAQ/ϊ =0 {B4sJK.NlZ <\Ǹi?= Մ5 Wo[Sl $D,_t`oީQvE{XJԤ%Yn^] `of C7CG>BK]6mě*1en G; LuNbw2;k)Yz6M6mX.ظ`AI;H8~hPդvr,P5 Y W_gP%G߈h:"JϦ(.'%(h:^.X#Ìqb\_+@ކOL,ԩ$gYu qWd"XtN|Щ[BFV;945֐ ElZ|jXԤ4Tg;+6}Eґ4Uܳ/!;aDBn%)nb"(3i"mD0<)^k&DCLoJza*ۻ[{ޔU|CsgU) QjaUf߀= ZB]SC^8  X7SY})8tڃ5 }[a.IЁ%tAh%d w,/+TʸBbtWR<ܗ4Nu EJT6頹هNog`og8"x#qmM] C?.~ ndwIK xMv0D_W@z9FU%9@쭑snAͷPsi")OIf$纊h=#XTlRXyi &YGI%6MFbh9I 4zwMmg92+RT|dO:-Ւ\KHd=bW2)"K)E -+6VVIsTn_l!?e+iO_'8~oqna^lNo6B~rA8]{A2^„-M9akKgqTBкɶ ,9场U,:^C:e(^:ۦXÿbjW[JVR"S6\]2ֻ(ZU";4)=9VRRNMo%Uet3=d9RTrU']i,MSuV F|Z X9gyy[vT_NtJz+K;mݭRv𻽊sU7E_HB_ssJ_FQ Oh&έVG5U%2*=x0.4${,plCC i$a Z &q yS9ȄjEi(G!!aZK@رk:U6F[t[(KUHAg$t!ǻkTtS(LF켁f"gGؗQtx/sCU5#kȷN!,)S*c`FNuOJbPP%[(ui7bvJ7'!b> gbfYrJuOo]8!xH;|'!oTO\M6zVR RqR?vBJ:dF~Gx+ߣ$k1PXR)G288̘|i0!ۮHMyXr)x%Nm, icӲJ&I. ͥ!Q(nyR̨;FP (mII,4ZVߜV/x(S nPzj۪L@>X˵?f$(i F3?eS*)\:TڭN\1᫞g+NKMب"Puq'(4|I@ƺLm:N~Ǭ@ <>usc[l: U[_ڦQb[YLz)\(+r]@ v߶ZƿOJXPJ#|MݮƐV }e!Ħ;E|L[C5eV8zK&RZCXM8bdy+e~b#2 }{a9VS}9eYkڤ`r;WOO֞J-GyN`%^M _?F5:x&)sǞD(.ķ=Wf:̤tn_9Q8}@[h >FU_a^[{<-Fw9&l ELnϵPFEN3.ƧNxN|mNr~q@8'`I7^ל٣JUGF"Ϗ4hߑԀȞǚRk#Mٰt,/fFl:bVfrMnpPҝ%?ϑ{`+z47(^xLdaHC6"czD޿xwTd#vc3/Bs1tzmܱ˺U6eݚ$ _ wNoȵ_oaTmpvMANj$lhaf]Pܜ&p _/ML y=mQBe2me#HhBBRIk X+ h Q ]?f+TeU{[VA , poƌEDM[4UK6~r*R9(ٖ $f?-[̲jڷ3?}79xͬʈw'JvQIKE&fIQry*HW\ *s!>P49=NJZI7+7'j}˜Q)Bo8J0nbWj=-` aiX9^ EfXɸhnGC |i]i1J`T m_%֛rq"&X[uvKjʫctNke?f\+3KZ|1nzGbRb!=A_˛%7Cyh=+_֘ZdSHn=skcA 3m&Q,JoGG.a{8TE/l}GO=H53} ,z 8(ր*0X y>sXdST Qtf/j7͊5ڼ?g:Tyrlrb*>E7hS7W"r٬\]oӨR[X:ɡŗ,ouF8TL:ξ!Dy d7&]OƷ֢*ʜZshC ~0MмRt =|c% i\clmS4 gW?8F6s]-Fd=жV|XLaܿ/Cc;=]{tf<2}r6D0^&X/ɂw,f@}Uo_U'ː T?=r1ZW]@D}k;ȎLeSke->҉Ē2a*:b⊫Vv 8.Ҏ* C9&tŔNeI"Q:c~y/h/ @ 5k^"JATg+tJȤTDXxrE'/߬shu{o>|aZ~߈vOQ.e=SK69V#ZTҧF{~7źhճE%\9|.uUmrqqo-1Es]O_;ü%ovyw\DP=Q _4 l ,*RRw>ܜTI7rb݉J# Zېt԰9жSa%44:1m5Q"2:Ӓ3x.Vgîl) ^'jC18{߁M{Wm%K:'_GO՞}Tҋ4cyCF]9ۋT(By6I3ۑ_&p(r][ܜ(0̈́\0`=V$ʺ' z~h}G9M<4i&p5 }#T{Vfp~X0$OYa&\)S0^RQchژՐ.:OM)MȖ_U8{ >qE2:rm#Z6:fKXuQ5h_wP 4+%5qie! -m'㔫6vayr޵&QED~=c3ܢ̧fTS.?mk4zGeѫdy8Oo&K1D& <|߿{ -zGЂBrVό'dw?Iuv{зi~ќ~B`*j{|n[tTx&11ap vF$:zo8M@@nXĝkК.^s0 Պd?httkW/aK~F !f#$mkߥn7,46BЁcwt`>j"LT{U\Ch]s5$T+@XV<|$< 5MvLWs#F~ go6P`Wnf^9_K{ qPH4:< p5F< !զd84(/xuʾr!^ Vp!^R *䵐sKYrhЮ\g+ /SJ,BR3~ yl]%ۮoϽʒzb3*f6.Di )|BF` %]!89V}MZA1nfwIlwɁa53py.;d<̭' D4Hƨ(AFI k4rWZ w{mahN-8A=1 T= |S$xU{7F,Xhddm3`ۨhĘnpAMúa.9ź+筣DpAůĽq\sغX~#PjY' {x v:͟jΒ 6jV"T~OJΑlL:<0H>t [/+7R%@ZPM g|a,B61 짲VF 6( k 4teGRzEa4nfx'F^KHPzr-ˬi`_'=1=֘Z7ye%ѷ_F<`upy&/~;Pxp椅ԄV7qbN$l,;%sg\QYv#\b'H؊VwrEc,UIΝ FJ+U 7Ր$NVb-x΄) JMD68& ƙ5NIHX(E\.(e5R,W,{Qkߡ)T_Ifi(n3`Y#h Ю? 6Ə{@ b/K<}n>7۔ Cp Ɂn8F1HV1R*ïHghoB:6?Y>+7cnL&r|VUdq8ɦ^n4>9FW.̶*fkj"tس]\\MKady VC_@a8'ZȠx&Np"[#ag\Jl|yYiS:yv;H<㼔07 +.`zģG/|QfbgsDũ=w}>t.,[σ``j娧ޑ8 ;IwG`,DÌ j(*VᐛT]BV#U-[L3HPMZtm1Oz*vv*TJl%08!iďHZՌKQMֶ8.67 ,+3if }@Uf,ϣ$}inMb,K0ߣ+z0p^jw^=Bxu:3T&o'FBYjM.JǞ<TE yhٖ OJ{<+5H]DƳ.ILS?(9_4z!ΰfXWIdLdܼRPC7TEqH1b(6b#Nz GHRq!g_6U kXRr]ů?=W_Ko퀦 \ۖ {E%YV7smG+gs8+ف7 p۳8 vX^K-/%܉YuLڟx\mbHjcMC3gXSXz6տYgs{jr;C2y噩Aoq+ ;(Sp,;2<{i2:^\2v;;(HߨI3=:y ug/08뫎x_O$Kr:E^ |M)<3j6vslwR$}Dmew{PD!z!ޭTrK|j,a !7)5{ͷP.PPĹdYUg%}y)]v0{jgtTg ?akmbϾXm4 HR6np|M5(ڢmtH)odsya3bͨ6& ~MX?JE=:X:d:Dl&m=U 9w^tCMb@FDc1?)iRIj"nKLRܚ*/з;-+ZtOX/2ZOU>+=B]pJKzj DhTkdZ`=&?W> 6 ށfU ИΡNc)CGV!f`@p#" pS*i}HB'd{jg-CWlΖ-[ZUFɲhK}.rߍ/: ߗ6D܂RF4Y3Sn&7P1Pk.aǘ9 -\A z`- {r`gNi fE5UPIhgݬ ňhA¡dkru8kUB$%ct dt2FJߏ; .ͪ|>LS«dv7Uweh@JQBWaE 7Al 3ȫ+g~s T [n\xv;?zao:L ۱yH pKp#>lJ^%$}6OWC~<pkkI|#q͗ wTǍ]Kު$gBH.'CȔ"J8I@# |{g,H\LhMأc}r7z+[Geoԕ&sA~%+(oI7i<\8+-f7ݙ3:z#4/k崭IW~}%u?l+vݐ@kB!'ޟ@'- #aEg^?h  ÅqkZ\ o|vH=~޲F3Ljx`y~ }' 3s8ל %#Ņ9ruUL{cB08Qi>T )H,:[@ݪ*| .̌OZ-#pTy6 T-kBPQEb PLMņ3g[][`[_AfɅpYO^vXxvDZbQn%7\ݔT1(/^rfT"XSX c nBIBβPL97(;Nvb@!hBie{;ӛ^6TV c|߂ecgld r gR ?m{Y`5} TLo?K3&A[y0a(EQG6aKh;羒E-,RVDWG9v-DU,&vDزO9Ō&4g:}qcWDR~Fy>XJѣGe*`a@oش:CK9K^DYm"hhT|^xh4hAX0 Dj7ȫf4Ǣ>s{d{Xr£u3U"X!J4p1 6g:K.3#)Σ'L%*wҬ5,9I TYiTd۰/ UQu-_oڰ#MȎ v4F"Mp?ږߴmJ/>p 8jΣηbb^e5~cRٷK;xݏ&}4IMh&ŏ]/mrOmRvPήu],i!z6Mm8{oʱ1u{~FT 5L40B[K@ `K%LGٙnmV7 ~_j4QMzug u3FJZX)8a1DY@E/ӥ 9af6[uHT^޴ uQ$@I}v$5Y2}RihL:bⴀaQ學dt4Ȭ5)*Y˶C"P:)J lT':*o*lɬpl?|!˄ӛ_JR`8D? P!;`%{?]*{PÜgaEjp:XÎ`JPRQ,l)+.L5&Qom^ܓ9r_"7jwͥO]] ...Gg׼!277jNMk\ұ.~5u%& Ȣ<.rU,`4 zZ @Խn1M_6e6{וޤZ`at}̂ ,f/z.^U;;uU Wm1!tZc'y{T'=U?0#,x++Xr8&YV{|1\I"5yR?T9&`(~}&l-?*`6W;hn`d Z:P@nfiz!T3S{h6r,ʢrX0;xaSh#<-50u=vkDú$y\ epƭWyL68HK(Rk'9t<,RfH;C͛sKP2 CKLuef-u8ˊ\SKgY LN\Ehwe#LJE5S`c_&Ugy]y -*Jk, .Wה1 (y}B)Vi[C? /$ǒU%48qs.b[.4&yw1MVݞzB2\hK[2AQm<0NYBT9tk'"dj: X>F\Ѯ(ֲdø4J({YA+VUZ9s&/08 boU8q(`=gR]ѧFxO{Ns'b2>9PݢRP=A!./z#v?r<T0߼ޕxڃȟ#GiZ ($8콜+RR1…F9Q?qгe.w }÷DĦɗ^4] g6R!aS@@ŨJ)ʢ ˛tFTXU(I/G4l1:9@ 6Sq"bވWK7d׎m0h+A]}Tv)0`%uLڣMxo>Y#:tKum.i<~FvH7H&qjTH svQ~d-WNI($A->yVW))tf7[UbCDrEG n"?֋i}I;džD29'H=7S.2t>WC^s k' &YE܍Fxip'pEĞ{ l^πI2q2@VU}.J AgDQ%T[)ֱ7b`"XGLщo#y,\S L:E_jpjѡ:%DPgt[":$,%Qi{ 'QjR.JQkEUPVR9fߐXM S!La"eRM[>55*.F,A!1B~\ԠnFr d.&Cm9Z© , 7CF$q'L pk3\ú S2R=B@iYyJ6Lx/ct`&l@ ߃<@\6yti$`' Xe㩹k,*a體kd,l<55X=hY B',}dsQ_6^H #bX!My>~oi"$6a?_o m4b73MMjDM+҆ \M7Gd/WJx$x @*b4gɢ<Ʃۦfc>F676 ōg(Q,=[P(;fqq C Dl я3@qجM?0B}5k SsQ8Bh#]cg塸y'Ҩ_G㩹*estC{wZn}7CӌRٻ<ޓG6\2 aQeW |Tk3^i'6Ȇ kcԄhyf ?5z! *9KEid#%LjW]<5ס[6.6sGfO? 6V~JG<#Ȇb"8^;,kg[A{E-k~ET_f?ހ4*X%V6YӋF&z-綋zFnGZ#•dS#ekG㩹UԲ*n}uWS#}U۪u-Ob[1^="σeĜ|V4*F|"BS3,&4.x#M[L@bjK_? M> +$k͒_.f''ҁi!(OLC櫶XcD3O?mdk`݈D Xs&CVF7|"h٫h:ׇ-F_urmG2'ܖqe2C_uZZ؇5%t_5F/gͼji( .AsU?$9v}@:8qtG/MQIrvT)xX #\ Ԗh\V(Auڃ==kYCm`(Wgțo"GhG 82Dg"Uih 1...Rt/g5\^o( GD =>ZXZEճV3KwL'-AP2`D`5#vБ1U]SfZlZMZZ;a*D59 Y4B e=ZGk( &$ шb&D="YCt7lB5FP%t(dX`/]Y/ wBs^m,KY<= GFCM0YK>ʀ`nq prW֛y}{naSo%Ihy6tvNBTl_w BtF%(|o?-ݰ.޳ͼ EW\TIӠ<[acM'aJT)%EAԯ-trYIeR;KeD@|V!k&cg Ҧ(3+np2>m+YQf9:Rj}\_{UΗs;:ca +b=ju.tZ-Q9MqyɡEwS!{[ @:eի;4ytLn~}682$}F17Bckݦ˭r+7B7{ٔ1Ɉ֦zki3 {B.@5M_ĪJ9̽W:ן̈=ׁcM>9lxC)eL]4(!'c[x;M>] N:νO[W^w l8(2Ȯ們~KcYBrb.%=1b|}DL?#N80-ű.Ցw/hF!4=/FolY߬֫IM͠v_=j7y8#4 p*&_*B 3ýX'c *wXxGF72q x?,FY 1B=ο9т378] X\ t_ B b#Vz t'^vTYț)x o۳ˎL8SJQVݰiin3$ݢ[^,ob^oxM8"& _wA:Q= *At<*Ϻ:oViiB]#2cOEG&N ;m)T$SO[ @p{=O̘][mcQc*QgJd.1{M80 B 7䓹İ}b".Y[twc _Gf*ҟ dL?uS /3B@Tm!g ^ uXd.128 |=2Z2+xPx| \fk*-:JwIsK+̕Z$\YLR5̴}_Ƈ}x/hOWU(>1[1r%.˦q{AF˩bttS :f1Je " S-A #q_XQ')Z6}3%lLPca~2:3ZPAA&t@Ɖ_OdWE0b;08KL5W R ֹ.?X%fV!iD$;w lr7wc5!.]5z?0o{ B#?"Sf۵S>ۣ53N>7$"o]%9+Gpߧ t> ^^ؾ?Jb ɪ"#y+r% i+BQ_abF)3ufe9!^ua{#6Ed]m~\Scb iH\CȈ{݆-#wREzn2 -"Yk\Y7+1%qڧ;ST!@?! :ְ˟"Vf Czb z_ +%,6nWPE%{}>U2H[a,?apLϞֺs'r:.%}BtRI d=PIÂoAE 9\R/U+ui`}e J]U#yxʻnz^B 6MXt ]Aԧv/q4A?9`g9yI)f]k񞗺\\CH,b5.;rlH\5u&JQsl}PFKvHaxBpC>BKU#ag^9W2v34;)X|a:׸"eCR:ʷv]+6Bo^^m}U d* mvew #>EQap9 H]w~ߴ5P.cSRP| ќP+ \|qG8-g +]d9ꬲEIuGLm{c͊qE\#ފ#*]*9@Ew.-*,ASp6 U*oȭ&[vn)@$L<†ݷRc֨i.;h\DeؕG$l!FzO$rF;EJ;hS֕Wa:yV>LCkZ:cG(M#Whw9iJI6EkG;5iF$4‹̖{P]'xzLex|Z&Ԥʳm7)>AjW#-0OKP,eQ{bR"#se, [9 GvJEv^ox]wp.jirVo󑃤!]tc5թzȳH,l\ I;rl(#gASxuŦpn2S6_ բC:l x} TMUg^-DmOȦsY!-jwfDe4hOy^ԩW٩vђ)(\]hagtW{q9lYC:Hݳ }}Lw@fWN.T2s'tQ =rny{# -hnV&ҕf*1:i\ieVȹM0E*5'U5Dp (!U o|wޑ?o{X]G^<'EНɉm!+x5|F\ kFpݚ/@5-/Aѷ.H$]cz r4b@n[0 8?Cш"؅=^wL$;.J1'dHfMz|ݑHC+~2n>ؘ/ڣ}ĵ_`$Px Cbu}\ij@Q'ujq]2)` \L&sIb29p3~=L3x\Y,wCh1g KH"^1tvw0Kdk@4͡BhPSuuglCi|!A9HDkwK=qPO]n}$xK|Ӭ" P5lrW=(ڑEw$?MK_CWZ1SWzR Ve`G/D7P%ɷU9ۑ#]v9 ElF.ip`G\#,Q Jn\<0M!*YƦ ̴e7DzH7<^U;&QIs\ٴ7 u洳 .ns9?"ciTrD#I`ʛ+xǽ+x;Bh0l^IstLf p٤ ]iNTK,-{(_ 0W7YjUgaezD]sH"+zfYiVih..Y'IsE^z(Sˑt[Yh;r 2_A6UРt|`uG ARoK~bsӭvXB}swb#Q-6׼g5"pFvĬ HkœC,a6K}nG|'/weo8m?QpY0󃊈ȉ+0Cs_};;!,?hكIr-B۟I&i@k|p|񹪩 M dBSF%cL`s Rs6hVi&^)M^cf1C0|Calk4xb0;wUf[X4t?PH*N bfIZqIq?|9~Gj;JQTWb`[XL VP)Iuy|4VA"D$=}@CL;2%9WFAgSsYe-Jjl@p7" yE8-]gF2irSd|n0ԪTխ$b/׉F+_uT/# SJZÏ&&*% @G+30ܹ,zs|\?zgjCmQT{0ښv mp!&/y,MC?etJTMөRZot }Lީ\MV8 jjnfT[QҀGN( wjl1}~f Q W8cb#ck -oVq}}TàشlsUj& K&ҙ$$`U& 9/DTF5=׎ԩ59 AJwjQ"@ǑvV{9YQK7=歨ǁA6)k%E2&7> Y8ج -[9|>Dj Po .b Œ{Y!&%^Z\65Ll.˒XW,XZe!Xy 7jS# EqHŲL&O~*ϮZPcϩ}*4*1yzj8eL8"! ;< / KB"dnc{iYYEfwf,pStUY jPrS \Qm:AQj,/[J5x =yX?ðhwX;,w` ?yEb Ί̊QVwV̏$+ڻO?Y~@E,+wYq}VOwV\ϬobĊb'Xח}NZܿJoɊY1jCb%Q꨼)OJ%($1$ el ՃcF&ۼ:5w;QH;i30N~t4FX[Je&A):@K㲨֔N`~'~}ܤ']1id|R Jz`9rVr:kK_vL y<,t99Mmצ<&oƥXLPg $벳Hl0tC$sWG~yrÄ7n=Hvgs*E9j5KWͮҰ=fȥɓ>fN*hg?E+=ƅz 9[APS̅Z:h8no#E[=;9Ii.F}g CN?qQ  6!t-t)JMwj"dڐ4ek AhsS -S֦`뙍G{٘}u`.i{Pl ', 5X(4ƞHG[t~j'O0B~R {yn8O9<>i8HTHRw W; 7jT depsȑ#xfUj`-;"#.rGrvEbFbVfD<(OƷA ѵ\/JȆϧ~/E{ ~b$9}FpQE=6H|6 _3L~Wo\}}շoz`֯~l}ַm};l}O[#\}mWo=Hت^=wAOr`ܯZ0҂|ЂHA]`|%)oJz+ _ Uor$)/?L7+ِ&?/H"SE/Ŷr 8|B`s8Y@AɣA w#IxDvyNnE)w" ڢYǦG<foB2ݟn5cgf]@[zW2ny%.ggli|@ŹHr2$#Z35ru$4g|qӗjaJ5HÉH g(F6X\.X'HMq V}{A#i_qxsFFǹ)j[)̌OM*,H0B`f"䙴|r)׀Rge'ϵ$c ~iZ71=1G1Ϫ‚\Etu>@V&*%eqH8;Iqq)d~駇?cG3)s GC73w]\1r A!n|狐gøv:Iw@X4'lӎ UHz `ӂ\Yq_7[K G$*rRsO+,Э(gDe¼#nҼi=ңÏL{hY1\ 4IAal=O)XpTS*wT=A%vQ`ۑŜs;rFؘ#" 8L$21ҊaX)efAS&ok4xwʧ+!vrS 0Eu "_oMYct[|o"SrF(ʑgrdM)r?!qni1'캪C#( QL=ҼV_q#jC6 u -nۼNʤ@;wiqr^hUXqDMӶa8Zu/uqkp:OV5a G]Ev8}'*Ǩ#ёyl I3Jj/Hs7l`bj3V]V&C f3W܎^'+LY2F난7/CJopFxNO <{M(bN8!W!CkDOCJ^Sޟ_빈w`0$igQ/n{W9>2ymB"ܯ߹ ή})}H(ppd@4eΏCKta 2j:#r9t[-_#'{5-Cct;yܽo t=~G5 Q? Ľji=ҳg6Nwb:onAnL/>8UXu65X::w3Lt:'ɵ\;|9#WG D~Vyl9;cH06E"pY9p?iZ$5 1kDw: .PF݀?$#&MtG H́@|@2gǐj0#h\ڜuASlJq snqEԡԱ+ɊHJ6oEMߢ4,m{:r8?WK: g*^$T_7(奲1Z"D@߶|`(deO}8#;m(xڞZh]z&wtwG z/5_R-+5D9LƇNNh-*QgU5(D튬Q,hl/ i*T8td)zswIeaI QN1KҐuA+*+b ,ouƻK){ԼFT1-w!-(ygT {:XX4S cYe!oG2@q% p]yDAE@O2x|>TVg} bHu;(6hUԪ&dŨIUuF!l1a #F;ѶqX񹉫 M+4zaWp`ˢE$D-QX +;O H&b?)`W}p|xǶ+TC3p&EeiK.ӐVTiےm.1g8#2*aJfszTi}Nbi\ ^6NqAxz#]V-"Elh?܎nIil- j>?Rlp&*$у da]9&xKJ,kLyz©b{hdI@vy=r$ <;LrIޤ&nu?~m1k)yRA!oُQ/K'+Q+`(L&IrCt96 ԃč]gעݮ< Ik{t v3qAY !OCFNfsS'utZۺ Jh}n>ъRqF`V,됏Jm:lZM(c;RuFMZkg@jΡGr)]ԫr>*'JV n@+U  jxSwD|k({G*)nY,Uaŋ*nUU*xU#.o"PIf sg@7) jvXݴ4:M]$]}2XFV7e}fw{Ok{KWBE6ף?ZI0&ҠR'J"t`d:=ψZg$9ƺdvqF<92GqS?ZL_+3Xh9/NI֒ dgQWog2ItQ<{8O"T(?^<:KLV7ET߅Vs^G%B/$Ô# a˾ +=?Ohlh)Xk_c;:LyKxPNF5Ĥn8#̪S%UR*CDj=L'S œq<`2;x}5dFՃ)2haDl)2%ܟ 池Dq<;>95q$+6GPf{p`l?n?;|^7h]4$Za:6" 1&%%vQ3ه*5L9tcD02'=O @w$5M-3  (d! fUL p8ԅǷy"-nE0fS┵Ĉ'-L]I"B!zl}d=X"tX<ʁi8z0YttXW͔><ym}x4Ӫ)ˑ[YC # 6>>=Rxm9돪 %/U37qE_<>Uo@=#:UԤ%WwލdzZ*#sRZLx ͈M颔"ƽZ~6g(2|G=n['p4M%8*Nv(0N]<6Ev(3n#*H^|_g&py*2rQkm(9d-Z$7I^ptWr0iZtHe]'yzi}ߌv)&sG&D6v!%0XqGhiM-Wa;𣧕,9JٻF/mХ)D)rKW;TB\ <ꉇ:[I{oeU{nw+-P}$'SdAPX QzUuAOI_3iT.Nz֬Up!LEmd3hZPOqWTs`i3KZVm/j(ӵ6cޱ*p޼̓6 +g? .ukI@4٤o<*pV6#Xm '^KZ؀7ތA*+u⥖#Kȡ Ia0GPˬxAʮ"C8 K.2XW GϽy+t lSc; -]@kC-1d'}j:0}:R;e~=ZBU->Ә0b_[״ :v1'o胩Og9- ;<.+)e0&اn=^SdL*H3'6`xqBDjͪv.z$y:yZ г#x22E=(޷4Q_u9MżL'D3Ń'Gcө$SVMubE{8mfG9v#8릦[afK'9m|.䉻NZ V~GI|R*[ׁNN%BYaMx mQob@YКa j@"_^j0k /´5 /01Ieee"ˤK*;fUGJEގu8c5ָ˱0!㨦خbD[`y*͖\١=MoX%I݆u.ԇ |#<#LTv7LI)YKFֆ6g|#X 9kw|8 v ^BItǜB g]kdmvC$8@#RWЇ\i2 4YXNfo},v#FS"@z۴\;ډ2cɽC.K/&ilϋxxmhJ{&G˞OB>~rbH%)0~Sd}ҠϜ&u0}$2^Q n:AŃ ᦈ.Xq}AM&1 x]liz$oq&S'Mv 8(ـ}]$?S06 DhZSR?1\]ʿuvH qUUH-X*A ^E7Prf}fAQ4YgbN4g{XbP m z (|JL`,}b[iIX/fvxmv+h,Uf\t^ E˞=Vb8HhjWMO2" }R+?[,1%J;;m2_lOP VÔD`.W81oB]ڇz錏+X9@9H.a9pJYR=JǗ`<V$5lݖk:0kO478SB6 ܩm (}rE+0-0:6뎫̚RUs:E'4[&gY#SDUɧfܐANNoV7fh"8Z9՜>_Qiqg("a>Kf 40F^ @R4+M'Q:*!e۩0/5X&< g )NF8+q.#)HP4t?ܱ|gxy$`VgqA3mX uudPJyqb`~߾=`k/=Rx*o$o5ZiZMho ̆ c?ϑY K@\8R8Fz&jDlSjX}6wA8qʪ#!'fӇq{4wܨ`(pVW^U$;I4cͯ >R *ShI9 ` 51еoA!%y,l&L76p#[X%Z#MRɷ-|'eJ[6 o5i|\Q8,47vml .vx%Ύo$ZdF,3_lF_Z>입.;Iy*lRQ.aC#fI)U1&A IxQsT]!d*HAlKA=CUAEm7yu 1v;uofHyI*OI77>3} (KoVo_eq.v5w΂>jQאR^4=UK| A48Ǜm,B%IFp}{Wc.3Ɋ;Jy4*h*VpoOLL댋=ǿ.o-86p67zߚf,J03hm:T|zpr|6?:b )p J9AV=Txm'#s,֦MGqSXß "@2(*@]燛W?utNJ!Zt5hGڍ`ST`/H ".\,ܲ4 I /o$Pm#7]Pdθv6O{xeٺ?Gl3p~+'j3}-g #N$ij}aI)Qh@r0 ѥ@U^0DClFS_N5zrsN躓iܾ>.8]ꎪw> [)^ 3O>A;a%Q n|wW:, 6>Jl]ы>[jБҼgˆ @ k Ph, 2U 9A+ODH{\WCYWؿPH[Yŵ]Ff1qBH%SSU}~:vk>u/(^l$ON}~gV%Տfab=+-E4{\o*k`JQE,oI!xlL M8>oA FdWȚJ& 8 #ڮH/2rih=yў̀p+FiGk*G\/У *B'92 Yd~|D-(,i^!D@.{::NDǫx|kT@)q"!s8s"Mƻ=APz0AB].!"`A.e@*D(LqDӸVwܪpBr~viJx^~'zΫT8ve3^O JP ЦY?gxB?fVvXx'>Gv,vWqhucj h~X&ɔNgr&n yp k|mL'KSD J@2<,\S_;cmM6Erߴ0M!nǾEc}Lݥɋ7)p𴠛r@9Vw؇6 ^4D!RЖ}8PH,/]o\J[Lv %^quf,Df}#ܼsFAEJӷ]Vݾ>~'yɝZ>+E0+,G uTcBFv E0(X"n쁛 3!pxМSNyQUK; {Ia)%h'/y:{o*IjS.9*i*DP1Fvl}\POf+k3ϋ?>~>Ń/茅O1-bgsb J,8Z iuV?_ ϯ~oTRKBa9ܓA$w /F`Z-Gk2i MzE( $@4/;6ܴC+4ߨeI70){*@tN$ܾ{n^DqcoIZyZo:NSo eRt^%ƋЋVmW>("pJ(Po.;紾,dtRxGxW`O+;ЯCnoy+MVN!iqΊؒ~򀽫%W/X(}LX2CA*x+3قצA$ީq0vi}I[́J0eU_*}CV/ qOMT/ *}MWR{MIIO)yГ§n*m}Rp*[Xp[y8Hwٔj! iw }@]/((ijy }M/mR3&bb?xH$BVFu+}^΃T/{<$>3c[@JEu|<|t ﬗ ^1cpr/#ɢ14Ekta).Y-Z8H?NXd>"R/s-Q)7("'tR*p2)y Eo#Z)_.Jb9J}Lj%zA7%,bV/@NyMՑOԆ v#Yn>$j;@jLCJjdwM?K+On )/9={({W} }:;|hm"j=k2ls7h 2M迈$qt'*}%=)g>,U"z" ~Lp9LeIJKC yMV|3g%G3rf-ÎsSZ1ْMQk7`/C\]|b q3ǃ)YR®C:*α1Z{'ǩc 7B6 h)~6.<!!) ,ى{,T38A(RJԦrX1gHĤؓѹzQBXW=$tۘȷ6dQ'B:hVbFKy23Ԁ ncIW@7 &z3\Ðg&d Q EW.dqd$q-zQT򦙕2E=0~ 󉈸@#?h1W:h9R%WvVUc9.Ƌی"nUkV61f",SWVp(6SϛM(EXRSt1'or}1th}d3NW3^f\Φxɛ1MdL.a6$ZD07̦\we)<2sP-#02}^Zh5omHcvbc#>TmK-Z(ͩ<^֨)h8DyNq7Q6}5V 4Z&|x2 GUjMʐ]9vF7E^%ٱ0p_povHbYiKa E!tO!_1?r;T4քSW-Kv If|D֮e|$ʷWh+3J(cD=9sS{"ׁh['Cb4ɛDbÖwD ,D};ÿ۽WT4^jn ,U͝QwU$B.&S2\5 duLd AT2nҾn{Bb} Buh$bn{,-0` 㰗[̋`0#ɕJRn*Y@$KWO<6%$dH̓əI;r툫~[KîobF<#C0d^3Dl䷎'qm&"2pv2V J0LtK,%sGc~ܪg,1 ,q{%[|T^, ?(BؽS? 4JԩV'6<Քڦ`>Yi¿ܭ"~߀UB*2 C|ʿ#ʲ 9%G2uB 8"5s\@cY1. p$NCc9~s#p@*"s 3WwdqT/_$/ք}q,ejeo*`ΐſXk*Q&L#9!6r"4N )@t4  M $g/CZb0]\"q71#jan94-wB2z6 x|0h0<@otqfg&Z;$T- $Bz6D%1΅dҮC(kӜ.@`;>J\ޗƊxhU\R=Lƈ˶3"*L0t#$XGLh#!0{zԿE&BTv ioy&k~ًktK!8)!r*N/tFt,.`:W$'i,Yp[:.Oo7KܢpK!۪޸f*(qŻ4_8ݯ ܞhU:ܑ\&JpmJUA*/uג稵( ٳ|̙73L"JyB砼 |Dy4,Nnx$0k=ݐ_Hrx,`ۤ|嘴TXcQ_vo Vo xAM\Ptk*Q/h |fP./Q{-fLtfc9xt/-ˍ`4u0EX/,ˉ!ހfW)Ul?kPy#3Bf }ReABxxm7';r-d'"LG}Ȏ #g-=/@"'!%RobۑP D#B h̆KoOl1fz@v8ٌT,PQH,\6 N$5 ۮ'ɥ>Bk6ɥi$6%ٔN2ٚ\ OLm(Pڐc<@ބХdZG8Txeޙ]7˪$5l-l;;#r Ic[(lE77;镔zw3NZt TǴ$ Xspcn+D3%hNeW-1g$-C0-yڙ"ZL#HN>)G吂=Lf 3\0o5G}{5A_7a냯~}hplw^!6x7XϢIS6wk6>>y޽ñ\li?g`CN]X LBĞ{yI}N.귛RzpS,8J]WJJ+f":!=ߑ!A5ϞQ*-}hbCk7.LVh H_*7 MCZS$A>PLHQ d  35:DkYQ-+Ld6UCWv37TR" *[٪N&˒x5oS/n<6%. Gi =SOiʹ/?"Iev;D!^nΔMgpb)ݎAOI`莅K,|Ppb)]ʷR$fFprQIԬu7s 0I6X]R$T.g$N:f)VVX;ߏK %:zv*)U=+1Hg)iԣ If;%w_JHqWQ7@Z^DKUzv{l'҄)đ۱fBE.S#aݫ ie@8`.*jK]X #QmŞS19Nq׀I#|f"׼)-0J ? ѽO (yBs/>#!U,Hd& kUKg•OZ7[Q44鱼Cҥcu?5CMO3(ژTխî֡d8kmKfا,I{ThJNr}6 AR|>)PB>70ҽ^gŃHH]:UNy$[=GNi UWIUfo=˃H@q^~C7KyŐ}M@9US|:ax1̨;1-c7 \_;TĈ {>kz?2-CJvLBT"\a/J$=6OL6Ts ,D2.7@~0?A~z"uD?3}l%i=B$] 0¡GQʳױ|!A-)̆OH C*Ēk=O:|e$RjTQ0+{HPǂ1#r/˦Xiv@$mtnd2"'B'#c詴$kg=rT(4JP8eQnW2MZjsl0IalM7JQ-\Xz+mת:VA[yZ nUcA]dcF<4ؑfh&c.L|п kҁ@ƑuW#1]OќLwcjd15^!t)]xr.OpvcL&.Q, j_#oRd0 Ly^;V֓I|Ffc}H|ҳ&u+2/֏JJJtMlm7EH֩[ it̺$*aP鎟[ou|Wnإ ":j"Jg?D4 \ShƀB6Az!~r{t/#qڼm]/>dOwB, Np%z?xkZ\Ԉ}Uu9y.!(r%on |vzP -E-çzE^+jajQ(`97XG.ϭpjjl-s.p )Bj"!ޮ !(8 TWujD9oD%K}uԐP|*p|hRS Ab E/LvŁ|#h֫[l2O%|Z> "wGCx:nqKuv3\P"$_PZ\'k($ߪ,e.i١Aܳ<qvMsROp;7ąn]z;k93ܗi"Г4^I|i򀸮MHRVcН]=p"8ZzGQN`eOO8բJ۞aå(ܞTG5ujڃr(_{WzU~gJf Y7F;=~zVıHı]l4g;83"`xSX0ƒh.M:ыm dg2 0q_Gf{&VyǷp#¢K%Jʱlͨta`"D+"1BQ9 TͣĎk0c_|ʋ;i7C]o蝸vC-x$kP~ϰIKQP~62>:uIaV\^*@&jxvv{s%6t=ų4!s^#YdSvO@?kQŸ{Ov&zmjA/|Fz{ֿH&ۿ ]CB3@<ͻ?-q?W9J%[r̍u кhL[)iUĻ za#XFK>NvI A'o7Nn}ř^3#d<j^3K憭 Iԛ5ظ H =3&kT{[)Ruò- wO8 ^hWTmf;eF2^pQ6Bdk 72vxd_LCh_i/#x\xe4!vZˤ"[S_TZjN2Bnї\͠`ޝ 5 $ OJUuK>3vk7ݠVpF,YӃ2e^DʵQ厝j=TwiS\̉;h0Ld*Up !N(2meuHG#dT=?Rh(3䨌38®,!h1lU-D^}laǼ3:h5#M g%~zZJn3ײlR'bN51bΚk=(Q?TK0,(ZC'>@Ndp0E/OT-v [=ӽpF+=GD -8*0pnc?1/V|.BOȠsg )xciD'~_D!ݨ;-݋䫼ZHΐ6W9FB/*m뷳R]|zg_Ϙ??\)u-)]iµ̇e ЫrW BRGVmѕBlӀP%,2tjvpq2Zh:GĜH&1Ms:cSOZm<9کV$ws+;k@$ƕ~:4YFP/qQCIUva؅#+E;h\% b=><լBGt 81jM-F nT#1LB j0U" =\T֛EcTvf^'dp\z!BN)?ΡGόx +CiNTo)^^69$zwU,F-?b%!kE/B`zpRMzY(&kZ)4Te -<_^|AM:zOs4 8}f|e?^s~ڌ:}:(\Lp=U~[X`rw;{5=VjMnߋv9<&[*}p{z s3v e󻏐-[Lr=];z'xBH<7$pOYg& .)tUaɛ`FuqZhJvR}4V1! `w7mFG G:Q*h hzN1 죛OĔ\"s *YJu=.i\}NN$|7 $TV(߬l#cz /vz etÓ?uQd+g.ú+#TUY-{%*\; ZyFt<5`?Caǒ6N6fV`X sO#jK6SPpVOp8$4k}C'W`rcW0hlf>!\ _kTvk[su:^s+0;SZU`rǚ_2R^3De>3vE5-F8m9ja~Y2(q +j3fF;v²=aaI3'FLN/ ɗzãmFB[8=B3?X $i ~$Q >|ZG`_tH*2tX2p~M$4MwrЭ\p7"7dmW%qaqtZl#I]+T=Ex>P] {5C}>bڻzթ 5 4xH2 HtpWVJkMyoFQ+Y$^[uwG'\@DB0w:R5E$[!P!YdξzMrՄC;TDkJ;2l@>={4.x6׎NZ Q^ ֕EaWW#\[sx4-R3K) jգ[Ѽ1n5LZ_ ؅eBJ>C}σ˲THmzȸF%XИD1nx/er%G;Ň}/s(mo@dR~<bKGQm#fKlX ^Omy(6Mߺ_j P u׽oVJ02MPG Ň5 {@lw-6xu^p"ҊsoN>iu!ESvQ7%^i#T]CeIF5\Pv#J[2Lh0PO)YZMFN?NfĚsâ}#1/P?{(u> ́s@q.>5rNF8 #4RV-ʫqf*w7N=!b;?:Mx!4q|$hڷ(޾R~~iH}wK[|x޿b_5Z}An8`H*iϋp,U4:Rg} gU:mۉJC2s"rտC(cbo~| cb50MF4<eSP1eˤFX&YɈfgN{_Ka֬#PՕ+;IW v4:4ms#n4S{te%J( BY\d<ATKɘȁ4 `7c ZwK-l]~AAFw fI_S=vw2D1Է 8CBkvD 6+&| =K95!l g@_F60MRL+ $PZ@AFgloe %ёge ȼHikd $sfK}Z1!?iJuYYB ºdYM,VNRHNHkxndRs6V 9!Lğ2ե*{n|ᲶI6,-(o~oLzћkSƧ+ KRU+U0ER&pAAԎuՌeX9>55@Քf?߁11LdV*AT!Rk9^יuȒTG: |Hv)ΊlFC'rc껟J> Uֽs </( 0V|]fTLlJn?%Q\Y 40:Y9P(& F:NPtEoiiy&am=T{ ɐs wA|/&F0\ )Y_} %!\aй3k:S֍R|< Fݎ"jF\&A]Y+FB/*b:<BUʭz;8m^DyY7s?Zhf V3+rZ+qaE2"6>/.:DC\[<2YBb'*<}xtHg(.C+3jc73%c%bfBDLbU&x''ho 'ص׊*wQ˧;Y$Ѹү]UZ#h٠G$13JJ m`yPi88o%2mːY: 7ԧCR-,س-)o%G3:U6UD  ?DIMp&L?\T!ǓE} e ãT/-_5pڷ$*|gSLx-fF5ia&]qbIѺY]^QJFiI//B`2{pR>2PLִShZ5"N<ėTCt9U*qS-<=ds~̶NXf ܈|:Q*&}8nJV">lCTܣaFURU&)v<5hOZOu]Oy:7cQiݷ_NIN~z)tWs'zWoöNHDI`@N U.@\i 5iAQImdxV߷V~l0bTRd(To,e/$fj]b.BfuZQd$E51H<8Z w8;O2B{ Vsc?uNDS2`wL6V*Y~>,n,ʑ9kmrv@C%5L׹u;W㐀DG)P*cP˴cT4QLqCwK_<]KP7D- yR~ C5A쪒B9V$S]CDfkkwTl2 R4- =Ocpε+##⑒Ev-8OJ-sF=R\1nmXe..iD$J׬g4QSG)6k*'eͨ0{&Da!!IЂ3*4+gWtRҙQ& y'N郺`K6D|,(D=S"YDF@f{c%YLf#XSˢh0B4/J|%o>s0_WBay>%;Aم5%p=tgK1Xal~NѸ&|t%)Dmߦ7[wҨc$bE}a %#moB +Yϵ?Sq{-m?vW+~*h@u:&ԊY낈zzH};ݸg;nH \rBPG s%^6{ߝ+S(c[1 L!9"M.t):VHNqN0X Ai 8'CUB/#4f7#A ]gbqwLRB ylcy؁CX6~\e:vkP]naOQk8A9Lĕ2oT1E :9oYݫczZu1~vn* 6\z( J݃SfJsktxD3ӏuAK OIrY*ĺ22/[i~JZv qljh?D ʭCji3>@7 F qd)06!ͅ; F#}7$id9 uQ^Ë,5 43}t Kب{5]B4*glPCU9jcvV/4ruih[p_]I,tuv}B`*qM֮: ?BT09WnN[{z|:O7JY#ߏ9/Cn&̵i?6nD7usoJ6 F%FIۏg웦hCxNcgLwӄ}h5DK/B0@ VK7X7h"8:[ rt K kk7iО\ߢ<A "9#m@"bKkkCguc9d1+EO~:N"J8Lٔu^]oW=l^7D!ܰP4IƠ؃"Xd6zj/uNF3X\[5ډSPbx lfQrף#~7=bbxA2 "5:42㝴D5'4B8!.j}k;zŽv]M'pkؕcia#-uΫY 94V=?|Bo7Q% UxM 4\*LT$E@Ap?{Kv[kmkV >&]7]1P=>Y3R j]hPAF\0&kܚ/2URe"|d&.MG:(?yK֔[csۛ8X.] *R.X0ri ]s^^ь SiemEu?g}p_q{-m?vi++~~;4?87I=@ w*C TmmD4\9J/{4M:z^- ӭ 9Ao@sn!~ɩŰD) HvRP}Fa49[~dtAƠFdn?UE햛{҇r*s6A.Q#3$Y,da&sqT<덬<[hrIiQ `q(TFL!nZХHJ jٜܰ I-SbQ1/Qya,}S܄D1F%ӝNi8s#3!ÐD^skO08e l6xePV{2VM쐣íuĘ-wpSG|;@crx6J 'z}:7)ttS=^ʓY$>T| #u5![3וf q~}CwT k9/r%jČ wùpg#Ծ]b#>{}}|GO`7f lv,G+bwo_OhD=/. ,~4a@SlRd9v%D}B?HX]e@ߖ#zPU@1@4]UoRBHMe"|(4+p{~ sm$Y;_,'`E3~?䅮q?.E'9@椌/ѽV(xN¢!6ʜꟊg]G5=Khkcw´ޟu =G02 vB[t^p 5 t9q7ILM 5i}',͇C5n(c2",MT.6mIg(E =EdNy7jldbщZMŦw֦Bq.!Zo:|e$S՚YCɴ:*y ce*R(j4o嗺菹7hF_z V2&g ճ ]]=4+ڥTdùrU c:{ih\|{@Rf)6Hm^GN܍2<643PQ7*ZLh9@e%9h0c8@|ޤ.-ʞzpQ褃he%Fs`_zmaT(hI7)r߮и+LUZY5Hʤ=(Yk5<LdeE jhq`nI"':߁/Qg| TOF25xĄ:Ǒ*} ;+&T) :lFPO6a{ټMD,ԾՊj˧k0}?ߨ!SP#Ik=3,zh{@4nj́BTC_eJ .Aݰl4ҏ 6"^ZP+= v2Uاyg!S+kLRJly%XvEIĻ >ߗ&͞ [|?nIL?GchhfWU`&3u,yxIGyۍ/Rɋf1s @RO˲  Igcl )쬭Y!ܒT+8i:! 16e%[ xKg {&}Cפ2C6)+8pSk:<vpcu6cɸmsnqNhƑҪq9ф2&S MBIWFe[$5yis ZمԤJ8]a9e -n@TlO_zcu4P0Qt6HbHrFؚȪپ% {iLN%rc]f$Pg?'Siź(`Ua6Tb&4h^NjxpSDu Ebvwonݾ*%׏A ͻ qL\f $G5 8ҋFFwTzCޔR|H*P.< ߏ؜S.}.Iӹ J&Z&8E˭./P;hYĔy5/q?k<4TAQ zcS ]wWJ<:hS9B^cdzE,3i쁸zȹ7*9,AASYW3O|p8'yM}#H!bK`HQeD *^.h:=ie_4>a/f\j.Q!pQSUm"<30W:C,*W)MEKJ/Z CP ;uzGnQL-Q:Q]@R!"9"Ws.|A8n$v  V-8I7oWdjT~h QGY$e:1k}ͻV3>nܱqt}T-;JN /Qo;1w`RDQg|d-J6`0%{"śmL1uHG\#g ɯ+Inx@?""ꪵ@$2IC xt3!if4DآY}<,6#N3UI샢"QYTTEX=9|%oˤFDz7 %Qؒ𙘃ad 9b]?Nnr;A)XhjAPH֤qomzasZd"kt c9o6_<zܑ;=>*PBږcl x2AXw~^گUeSa=QuYAIAmtv sB `yJfaz175fˇT`Pb00Z)U6~غ y$V}wiЉrqzowy 3/m254fq\_5cQbh?"2kAVҝ :+WY rIΙČgM,E?%1:=*2vPL괐mD s#6*xg*2N$~9tFf1\.8_B.+PV gYNvs#Dd(^Zk0 >mu`ѯXn&|nāknWi$SG2ɬ5v`gAɭ- WpBǞJ7M"~x>%YR)2*zMj@Z&J3g!W9!p}wT_i#]vͣKb*:n E`i|\7) m|)S|:;p)n2ePٜ9,ŷ⼌-;lhC)RXlN7n1d`RB4zG[ϲMY3ΐ8fe9k ؇m^;oV1]4נѻpP<uTui"相y'FCysXᰨq5 )}[WVjҳnjFjgнlQ{'K9PHY"秀O8L]cvPYڟGry TqOKRcN  ȅ5K2}q7ݮ)ыBz{v\Ji6`9cl#wc!p?3&T t#P]6DLt;mpFjp`L;ؒ \[N5\1M^]e9XvXeU ˍ9f/"Fm9:طTl`M[TSNwC[6t߶s3iJqt ^:+|(qh6Þy.nD'`SL#‡5d-'0ދ-u ^e:hN%[-剛ԋ&r2L hes[e786 ՄӻXBppPLLejH&H? mvqb dv"ζR@1= *1> }3~=ޗʯ}w{2-X!L VltV\ E9mәжźH10ӗMfݝs [Qzv˻B,&.qV. v]]bmRGcs頮7B cI, FcQb[3kp=2 B1OJZ:0'ܳDFY_4"/l4K=dIskMߨY|', N2[>(hkA\Pɞg:ɮ`sڮׁ,4jE z{nRAitVHt9^@L**#?kڤ&HukYᢜ)>\C o.U:-$iz}\[Mvk:p{# ;<\FXʢ>2kϪygǼcGb2>_'YƃRIBֆM˥%_ZA|%fx~懜,ebWu> ېI9FȮ 4{xha: :&y{u|wǍ?1ɩqWwE~+Ɂ=O_ehz}iXuiCd]ĵ]ڥˉ9}+sIЉ+ . F+h.Q;ik 6T Ƕnj~LZ fvȋ[J1M?Mc\+q:U*B]OOo&Y.{xof@OD!aˈ 5d'Μb m8P&%L.;>xWX&1M2jیeS=Haa³AԪ*5u7a| c_=>rGmڱҮJ1Amz2 o5p'Q١c.f㧫q`_V}/6,jhi#h7xo-If a/Nr6eѧq_h@Q#º `|QY]o߁pqS<-;"pdߍ iFHW'$`Sߙ mV ЁdT&6_W8CyR@tDV^fEd&=vh4ZnR5;3-WY}$on=6)k['|/*f7Bg~ϸ-,/ N#xM;ZZg$^r%=*o쏒"޵L)^Ql`T=xH. ੶9;>}z͋hciR*{. RY&:w7"*ymzKSOut]*=Ya@OEf!Shhvbߒf'sE㵒wz _ۮ:'k(hH|{UFHy#6Xq]cZ:I{lI4ȸ2U)!egX' H=ph1]E%c5f$.6}֘9{pvAi[]+;ӚmF}GxdzU*r#?}'姫Z?cXYNhCSόY>-g]5!ЩgF3{򮾧ztTCY;UCOjZeF{iVѯ}|zr?;w-L9k}̏q0?8/b1b,''X_b`uM˯}xQQ" ~mTT4`QҳV e'۠ZyqM6es?7H*?5LYƑcx`Ϙ $3SyNQlơ${[d ӔT^4vVv;[ p zmX&չLC'"j 5 PŭE@D\JhY򔢜UD>fWWy5,F_gظ ќ.-Jl6'@L21CAab\ FlZͼ.ꭇpdv/2˶͸/w(-M\ l^Ńk<[O͟4|Eб`+ddSjzB֎qQs`F{6Y7yS옇~B n]kKyu3!,H1HGߚs e"/ ~cI0i!ݚC2*S/XZts{.XB4CjpW;Ո9z%n:+X&kճiA'_@k$͋63a$š ed!V5"[mkU=ŽM ݓPJk+ ZqlU9k8[M=G}ht?xC+_@"44Y?'ߍPll(2&asAqFDh|\jPQt2a3>x[Yj*i ܀G> JkX{LU t'M$S8/5; (H{T7q?N0־Xb[rJdAʪT10ᶻzlO Gbˠq_1z%1()B KJ#,L;GZ®0]8 #ߞϸ:s7[F}radI9t%g:Q/,&^^k%K`LhFrBR~/h<(L8e[еl!Vi2.3}G<9|{ꢕf~thEGƤZ M( gGa2 L wbJa{׬^q^U{Ɵвc)a"T؝ |0a'IGaԥ‚,9?`mW0|LXߚhKotp O~hZ6FPw~G߁B) 3 ؞B6m#4~aFЃ o[<<0Qg*\2ˍNa2NG3Mn>|ʱBkFF$VZs%'{Q$iݻ~2z;ƈfWA$c/X L Kzy$FKӶ5\IIr# Qv߯bnbӠ?.B}׾ O >%HD/c٢i= [9-Qc:8Ċ8`2R4pHI]YLI?S U?s_>vJ.qX$/ȝ):%sUcF>Ì8G}+V?0UjSu*e`äNP\g\h 3]P?&bs{.)8ܦsp]`3YjjlhqKR%*֐RϦ\=Cf'#FU>(IP!Di<-ufjuERDeGW`,f \!%/p(oVm]}{./{ 1"YQY))%W)9.Yv%6g\1Wll\¤KߚP1vwQ_ȷ3(\PӤR $VyP(K"  f}nc8?!ХIl:')y~7S|qxu4ac]tA+£v ڳuN.Dp%u<ŽIl8b`" 0a(뻫jfvvDv&WtWWKCm=W67bXŋ1)gjQu6 etR< EiN>FK3]`J5z=nE5"ltu0y9~c~ZϽyco{Ǫy5o;o;**~*͎U[ŽU[T\p6x13~*k,N>3Dz ݐXQ$qh0d#9磈 yx~b]|kLyN YHb~_)Kˠ*x;<`=]8G/͇Q>"vwɴ "x APX(7;Dx:?y0;̰EfH4ׁL|nꉻ8ׂrx+#pҒ+Fu43<:"Ha i"Cd.h1fJJ)ԏH[ěf 1d {nŏ{9:' : H 3BK`#b92HT/ r MW+C4*G)x&Lu9ѾRcARLz&Z%7l+;)|5MXs•=Z0zމص1z@;#psxI1Y?kPEo5KXJVj (C |dٱAƸT5JQs5zIrljX4{= ԫ4hhxl=ij|JazF-0s&O8Mj+6=Յ9aP-zHlh[.3듐qMw6Fyx .#Ƶ0~ 2 .q쑋ʬ E\ǻl9?r쑑tj 3D0 GXVM <Q b0Wd-q%֟Tu=:u#">3r"lNm#ʑ}=r9A/9A/M[ XijiHv Cζt'4p#Fו(qJ-c{a5SX>9k;g6, @*G-0DߏZL[i|mA M4) *Z.HdHUÞ[H&d\[n-zg-sM"pR="kؗAXG$o/ 8{D9bg|I5z1>]nȾuNM{HE.A.1zW2kXf)*Ӎe6NgzD}x. m#p<ε4N(j{eȸ2TꅼAk&2NgDLc~xs#ㄙ\8G1캈!q8l=XaiȵEdm?4Ogd 0Ўl3rjo'@ХXwµڗw5y32y#.$( %ng4yLhgZ=4?'tS:-tʈiP2(0H14-gb0qliH|5ntFC&Nx-ȩHoJf;QJL44N9錈S2f!RNL_-Ir܆ m$^,k#b0 R:3zSY(pL$||R[$5h\$:IN^{57顆$GNN8?$ߏN4V='I'6s0I+5@&HNȤ穗Lrg-fʩ+.̤L6fʩʠ ~]$ mW&i>j sy&?R[$1*Icx?B]$qqA@ M^gNh84]&dȄXu MqhD&Q'2y+\Rs/LYUbfѣdBk"&`>n-Y솝=uK.9ԃ[Z'-Ohi%i ,۰3)y4 DszLRB|\s2`dPIþaN]@H9iY&y6ҬּŒ* 1r+lqLL+9o-w^9UZAI7)W L!0 1jOLʹ)$ڊƸCa$Y8TI^95I7N:I'YJ^hkenJNɢ-N9b8+3[3I>=I=keud[%9T%$#\IN!2NXJN9o’č.X8Ks|S0 RUGLXĥ,9Q[K½ d\ST6X8G`Ib+ "c&ɞ.b->5ݕaeZ8IN9?ؘAI%\UUcˠ$P:2G#5 &pRlkLBFO0Icm p9_ISX1+X`Q`;cal^^$OɰƄ'9Ŭt%1v.R|J{HiHؠ9yGHI]Y!k'%P$T-9%'r*SΛ$cha3`R-؄S'Ph&SD2^rmjHA8xlzK{J&9Q۞ L^AfxdHC 1 arn I}1R0q)^4Ēu&ȚZ4iXٛ$I LNA^:ID݉)3q f#qn;29MdWkJ$-}bcJl ɸC5j5p8ty),/& ARCWGG=T>'ْ|LX96>Yu*5K^N6Bݯ'*8ǻUKk 6]S\rnܘy( iaP>M* E#/To7 6g~`iY op7n7G7헸sKb?z~{k~f?} n>[6S={_~/W?^'{Y|ߪATz/UnBڣKWoo4t;_s7/+͟/}3?{|% ooC{W#|a|v~OίR?ޯt~_1_0w#l"R>S?r1sUA;N<@I}(ަPaZƄkm3oov4jof|i:X*cLH S~9TQ_FG 4N}|E4sQj+tO] ,'zA Y|pP$-Y)-%155W/bEUW~ SلҸKǜ5@ξ}w[+{KGQg!a'PSAp-jַX(rsu^.ͥn8ՀɃ' f'*]OpH.SJZ\bkT &Pb=j޵e6t#s 2xy@=Dp5tdVɦ ؙmqJ&)xHxpq54]$ClL_[3!n{#6F> (^={ٌXHg?0i PO{63$.f@Q]d ┞dᄹhpy<10@{,J)OWA>$+f0H_4k-ˌOö/ Og&#[o++/`)RHyoA)Oǰ:Cߖb~7DU=Dzm/ve{{vsj̨ϏarDα̵t'f^ݙ -zp8+{wCCΰ2ղYVh'ng}%*53nտU^Kb2C$}C[r49XZ1'f^ w^,-mwr9Bs|samlaɮ /=`:Rة2`f録 !)+i>\g.&svQ5Tq@ٓay4&ξH֮e8WβU0ČIMOziz4Sux:CMPp= Lt6\i j#'iZ+ ݖVsC쨖Ini<-MU˧zRf)G":.7UjP B% yuV^1W95 $hmX֧ ՙ.,h*qJ^eR)}_3{I73x(hzO ^ăG$ҏ9%ugJuZo -،O)s>Y_Bƻ)_;P/ӡ" {=n02qL_W;Vmᔵppd|!.9 FW{Cg␿ap:-GЌLG4R݉;/}Qi=Mv.4d;gcy1,a+Z ̺ARw\{A%pצD;vRsh$~I?nS[Wp5~SvO<)T|Jx~ghpBe4$w ` ^QhSyenQ)-i_UZ};Mfb$엾6WZ;{J*|G :[45۹>0U慽u#}j!ʋCW7&HP+!F$R~4јN tOG5HqK$Ӟ;V IeZM X0Vo#ȱVE_VI\M̫O^yyG2mK%wL54y OZց(0Jb nkN4J5$-56w89P+d/QӀ,SP|r3\ܼքz %AT8J #8 " y 2`BMu>%Y7d  7-#̣C/X i&|H"ljˡu[iu^>ªo*EM Q@QuﹳHkur(T`} 3$meZËA XͨQ93 iuwiz)) D9k7o'˲6>élVdlNV$[Z!sA9*F@YcTjKcJy٘~~ߪ7eLhxؿJ@ɮ4eP8<r*1}@eGG6"X*LZYoR@`L*CՆTRQ`IMגIIʧIMk54gK,rϚ \p=f&7)a:o[C$8k'NθxRX~ p~"dWTԱڑ":# ; +2ԉ*r9kyO$ `&C{;$Pyi&YBVUl B6F) c'$]RM>)J -N>5Y5sHB;#^.x)^@ڬ3>"r:Z$;v4:N^jTW|@^>fsj߄;ن.J W TG$+%ɦck'/<ې?Nؿm˲DfmquKP'oJuxٳ{ZĢ7%Zc xwuY@emESC"m&.cvg͸9és^㒸\[CH:P+z QjERF$ cG묈\Ma|S&h4O#ZzBf#poWV492Y4 8bq1Ud'`D1S蚅.;P{! b6*%3)P*< KQB֏I뷅|IR/b`FIHsK?=rg#G|L:`FIg3@K/}DG$vR&lZސfw.цvVQm|)Qӈ":-mea,,\Os6Y&r;sJ_{c$Sh߳ ą0Lj$:U# ;ҭ?Mjʛc2^=*^gʈ-=7 Ba]lyƛވFgTfT\1ѦX߼Pkt.(t#:USdT:Lߒ;n$)?Tn㪧ao$um}Ŗ^^} rhWK}!GĎ'(e>}k}*-]6pDS|xfry{_vh>)f5!(b 'a m ]82UB ߉?ۡiVmaGXTQzoF(,딌NiOY?cN?n0E1:*4v_dI+F/)In#x|_ l 0|^#_t;#"Y]*sH6>/'G$M 8eRf{qECb.dB.c$+3X7xC.8ak E6vqDu+<~DkT%/`@̼iVh7lexՌcX2L:0[sEsd!q# )y]X %&dW,`H2DD/u('zh̒։ d 6VYڼ*3NA52Dy:Z3J&@kr oj=P k NHF :A\hL>M$0!nv0!5i e ,M(2xZѤ3vM#'+㡙}x7xkxVM]82 VOc <5‹WUj ; EgQ9F *^mĺUKaw{45L`"<Ls;r<%5~34zFkxAt*AS ꂤ9H$NJ3j!^䩉`.uQJ$s'hO!?8)r+ ``8G1̏[R3.A(6Un9:LY`wI suq>7%%.6ƙJV ]Nbֺʒ#@c'+IZ^Mԁp,r4zSĞx͡o!L!1 -$5i&Y-G*7^z,lA\ҹQ<306([05K6Se9;$?~q`3;˵ SbϦ-PK_5"o]CEoGƂD2 T9jۤ.bԇXb҂K?AcUcIlHAQA?3 Xkߓ5h&qJ"8[ )*daFvE3@Md҇jRj $RI/-sPٓh[E;ak Zb/dž&i0͝H PTʉP᳤`;/ZdCEYFX#GhJA!zWN#\JNxmFH@+44gNNo|B:yA\m Sa(Z(DR'eYMҲ`|YnyD~iSD|`< Xљm޹  * +:Y)]rB͐śkm=6 EA= xRѼMKvTVl rZtsG]Et."$n KF;1#:gbNV 8HP+AJ hPIqꚐSշv6l t@|̒P,䉞[&:Rk Z1*+[̼Pv`VhR#FV~yNh,"&vH6eN ՛Qd\mH0D922"A&$P;i$Gb\ŠV34 DXZ- M8\Q`![|p(Pina7ߤK{Bh $_sG,}Ӄt_aghiı찼cYL x(pGYqNZ$[fզ|0Ғ6KEr&/ٶ2檝 v ,DOܿsիߟG~O_&EoE4r|K({ {|׭x/\:p`{˽Y2sRZD79(pTcBѾl U(1ٱoQggGD/s َʼncK'exɊO<S|OQQ~Bט.TÝzW~J_]Q=y]@x;v6k;;>Ys2K*>v<; _9}]lΞ-ݚK.jZGd%q\?j}8B;g3 olƻAgΟ%xw-i>x]mwwn=CvWàK>O:W`03a ғ螳q~c|=9}?fo4͎#зWd'[ S%{'#|딯 yɮ>2rI6xhkd1#~(yiZ87N r1 Tg^Tأ H L fȯaj DN#k.VСWc/G%pS#>w8<vD`܄vz'ܧV~{r|J 92Z0?8,:l2îOaz[hWmfHQ^x8v-F cWBZ;ͣy 3Dv|2~q L۱/FymcOV=cfcc'6~63zky b;|T]\UNf3A q{KOi|v,g΅EzosytlciCb`%tzȌ+(vxǮqdgÀ-GgsR^ =2r^=@3+m]` W'ql; ~QOaNSзx߈TD0Z rb}>]!?8"L)mc"SօK͙dWPtSCS_w܀@\z;qQ4p#5[a%7$~ 煃V{3xCHqʀl)K"ymb!Xsmi jS@4=S؛. B i'r n@}=MAN9 'Ӗ-{ H^A;^7.bۙkp*,) yPe{܊L+')'N,^)~-SAӉ;uDi,a Y&= 7y![ *;ym ps,TspΗPc`Czy9µ@ )) {=X@;M7SQdE9g\5o ǞR-z b;|A'8*!syxEfĶm!C&%1,`eJ"$UΚ8 TyTÔzRHxZ@!=$1 ۝G4 @Uv4qnDESA \OF{Vmi&OoxɌ^9߆x7S ?I >K"+G"'VSt4`R$z)!\\N2$')A頻&ϊADUd+H,poxF+9;PGVt+`%ɠi#4Tt`W1jkB̔N=>F{ԛ ɐ9KKIvTel/^O*U92Q#gtdXvH[Te\D" !vOxcw"Kvp?-;mm/@w|9a )D:ϯrE0=˙I`hKX~X LT+ ._*?7N*a#C*2~Q J]wF(q`E, }kx>FѬ  [ ,؆S/տC جQ4+k9Pe}F:A񯊚ӈj$Q%7a)24# *WКYxȩ)Vףl6N*O'$_ԯ endstream endobj 2763 0 obj <> endobj 2764 0 obj <>stream Adobed # $&& $ %4/ $('++9+'()02520)7;;;;7;;;;;;;;;;;;;;; $2(!(2;4222;;;;;;;;;;;;;;;;;@@@@@;@@@@@@@@@@@@@@@@@@@@@ $2(!(2;4222;;;;;;;;;;;;;;;;;@@@@@;@@@@@@@@@@@@@@@@@@@@@ $2(!(2;4222;;;;;;;;;;;;;;;;;@@@@@;@@@@@@@@@@@@@@@@@@@@@N""   g!1Q"Aaq23BR#Cbrt%46ST $&'()*5789:DEFGHIJUVWXYZcdefghijsuvwxyz {!1AQq"2a3BRbc #$%&'()*456789:CDEFGHIJSTUVWXYZdefghijrstuvwxyz?h=P(榠XzHA JA$2jC ==Z@:z=zhsu+ A@AXz: =8AY zpð ׆+Hė/бcXбcz ðIbbhhX b44,X BpAhb 0`C%@ bPCbb@ d J H;vFv `Hav9;/ e/_Jv X,(H K0xfjܸ ݝᛳzk.g Ń_rK?gxg,rCݝu _t%Y;ǯ,,ݝŅW akpk¸ BP.  AW P` B,TIc`*&ŌB+! c\WlYwЎ(=WhA@!ub>xg6:b V hVA 1Xv ð%1XvV~7aXh%Xwa X`uX`uGp q\wd˗.wqЛ P&bܼo% Kˠ@y+7V*&jA'SP1!u51b  hPZ-@J Ah 4XAhaXz   " b(HD& P0`P0$ C`+3Y sx , 0ob0/ W~W~ W~߄% bdkBPBB5J-| J_L5$X5JwЎ޻B;h֦ustYG-]]`BPbzc! v4ŠՀwش;Z XŠwbzv- wcRbiL%.f;]xc\curcuy/&W^>}2t/3f^>}0"^Sx/wauy/%q$xเ.\!n\X, p!VaX\ .aXp A\.\.+@+!(+.+@ 1 H0J"P0$0 B@ C$ 0$ C #P Qjj_ PuBEW-zA݋P(wv+J _ |?.\W~/ @`] ka" AW~/j-B`%P.}!]@ E]jbj-BW`BXv+ ,Xj-BWdBlXjخ&Ŏ^ hA ,X֣tYG;C; ! !ð;`;yXyXXJ,X(XvbyXXvb|d @+Y!(|wyBPW|^%kwB-x ^k5=-:^hhhjj!{:BӤ uxAFv֤uc2>yrA#rñ!(ua ՆH# #JXv9Xv9C#P4F@Xv9ð Avv01 !0 J00` ! BC%C\ @1\C   J H$a`  Hq-\-;u CP"p|.;. >f(I.a`p @$ C \% lYTAbTxܹV w㸒Ii:saـƙ͘`:LwLv`;`;׬zp HZ_$tjN-zǯX 55<׬|.jO7!x;|&MO7!d.wXd˝r:yY K fG\uγxfasi23Z\5 @f3Gpj3#1jT`1EdfZE`4y/&`hSRXz @"^MMJa-\QaY \Y `jj 1"! BBP@1bb b"@   @`!"@`@0  @=@]W.t+Hp. .p\ \.;%  $@$ CH,nзox!'f;3ᗷD}09ʺPʺP%(gV~>}3 PX?LVg9_,ë09ȺQrkufgC]})(uf-Ny8PP9򋒏_{QwZSJ=}.J>Bn]ּErQع(lBn]֢璏Ñ&^O_ZBcr1BiFi=CSF>F>iFi=Er1عl9'׉# # +sIO^"׈l\|6t4Ny3˸^!{ӘR],!J*Kt+sɞ@֝;Qs:9  ð%Đ@cBc`a Að b;ƅa b0 CP&ŀCQذ[Lnn[TZݢݠ0K-` ;`@c[Yp,+ TY@*$1 P ZHb E$0%j5j-@b E%5jP$ $@ HC B@4 4!"@@@ 4 4H@A, IXv @ h, @ BE`4 B@0 H @%ZH3|!!P׏DjkBP\>9}(@k^>,ϏGJH,>QZ\Ww @.>VG @ʸ *G+>>pUv⻾PP2ʸ VBP2YW;KEiq|ˆpBȸ!\}(.>sCApBȸ!\}(.>sCBȸ!d\.>VGHsCBȸ!d\.>VGtF+֋xAJ^+zxsC@$frYG::GVcIQhh:I\zg:PV#GZCJG:PJ%!G:P:i=@jj!G:PZD:#1Ii@,G: ,,fKTYYَ E@,Gc M2Ԯydqf;0--JKK 9jEVaf+Jj-RYڢ"Ō0&@0Ҁ] nbm%]ZP ] Ii@WB  Tj ! @ @J1BP1`@@X XvJv Xv(I,@v v `Hc9( H1.!P\@ B@0 ð%  `M/[,ebά+,^z^,o°o2u'[Nt@rud}Bs'[:%ru΄ CoY:y.8'[:Aˈs'[: '[Nv .N,o t\CoY:y؀ jGU;hGzn]֣rYGt30 Hg#c9:hcVH=ZBA @ HcCŠ:Hc 0 J $@ A !@J  @ @@1 D@% (H ,CX`a$ `$pXv$X% R()@c9z  =Eh-!(B |} >dJ _H5,k _HvB$@_HZAdP%-|}!Bʀ!(~>* >kUYP@ܸgU2Bt^F> yPʃ"H&^F2!d@By/'#vW] /%֣Q ЀCH1 %1\wXV9VG7a ՇcId;wl)p,/Qrŋu21\wbݢ/P+[[xu`;ݢݤ^ qhh i --44+csi44+ ,h qM#CG7 5,XFq\zM +X\b\.1BPW @+ Jj\b.!  10(IBL` ` a0Y YYY Y f b =%  @AtHx@Ǡü4 !!k-zǠ%c4-zůXegV\e׬W}c\!(sX:+.׬Zˀb׬ˇV9׬5BWXAnQ"sXk=B=@@ v7:z֝=@@֤uctYG/MNñrv5`.aZBvcIAf-vbjLvbzbzb Ƣ4Ǖ`,X+V+-%+V+-%+V+%cǕ`',e,yXXvLZKIc;d% C-%ZK\,w \,.+ElX\CZMKp6@\J@!`@ A J 1`H!"C!) @$ "ð, ¸`\w@ H`\.(Hp$ C$H;J+ ʀ%,c9ʇ!bʃ*DY61T,ŀb____2VB+x-@ o o 4-@`JϏV|}@@P%WP!(ϏV|}^Iqq\,g$Brpe|_,{&GWhuEj{//$;>ypñvvB@HHi; b$~~ߨ1_w CO%~ߨr1_w1CPs;MEF~ߨ~~_/ ip hh W&1  @1` Mˀ @7E` B@b@@%!(0 HPJ@;JwAuu.u@w\u!'u. ppHuw\n;J\q pߨ/ Jw J!  Ea` y_PX,ذ Wv@,e|_,{d@,%r/W=VB/W=VB{+(@r/W=Z @9_W=4s~`/:V@9G2/:@9e~aЀ!(s~`e|_t +e|_t .!W=~aЀ\9_ +á.!W=~aЀ\uZ^uZ^z]//&;1ܲرbqWXbqW`,\w! L`:P;PԺ%y4n@fCԁ?4 .\n5. 7R w q7R wt]k7R~Bd١f?R~@#23-fAw?R w9fBԻ/AƁ(fMh34 ɿD_١.f3&f3;fFd; (r`X,ˢ`+7E˗+aX˗Ea,0.\AXV7Ep a`,+ V @!   `P D 4AAt wAtt;H0  au.]p$u.%  J!J)A` @cc9|}@Hy_P!&!e|}B!(0W,> B|}A J B +/W:{BC{!%Y_zB\,^eEMEЅ,^ Mc>`ˏH-xE,\}^! ^9xu#v2̵#,^`&^9֦;1ܲXbqW:aswĘ@wbwqq+0J㸮;;0 a(p\} B:H]qPwuW\B$;n! W]qC] YuB/UzAްW]`@Ii!ub>xܹV1H$bcBVcBHiBPg6g6: }<ŏkQb=z<ŏ^@ /`dX^@}@HzzWYP>FY=z׫,yPi9d#>/`J;x&Y0 x2ɖL` 2ɔe2`,e2 e,@ \.,X.ŀq\ 6,.\. \!W J!A  b` 0  C$ C$ % %`(HPŠhaah `Z`Z 4@+aX4 !(V@ d@ d+ @;!YBP,+yd+"D!7V &^N UZЂW]@+C2>wGZCu9:z V9:@=jA!j° @`V@,d !QYq .$hhc쀁:%t41`@hh441`@ @q\.!(+Ap @ !(+ %pb$$@ @@HP `A(a ac `Hc9@c`Hh!J`! bHj0 A`P;v :s;0 :WpPW+WTj9zEe}]!!s"zNw +%?.W/gpw@?.W/gpwBP?uY{;.W\HvwNs:,44.ӫZuzGY;; /:"ӫ<;uK/:"ӫu.rk֝j3NH\p%wibNHS>Ip]u홤'S2ݽq*BRZ-Ғou홤 &;QHb\w9bC0Iby!y0c#@a`:<6uð Ysa]Y0;7.xx;7E1͇`.1 @0 t\F bA b q\W`! X@B(J0` A JaCDJ  :3"` %): H@Ha`H:XA`$͇` @cNl@u+|!` BOXv % 0%  +up ˀx`p,X*YWw(qppW P"Epw!(s<,SԔ8';Z`y8}(8})޾> rqQrqS|}1k逹qy(}((})޾>}0/"rQPV~>}0^D9򋒏Owgo( 㒏O.J<=?)ݟ+?LiFi QQrQS?LV~> fhh㒏G~ӫ?LV~>!Lҍ Qߴ\x>:Lx(R߽thBTG|t4p!Q#4F CC 44@ð;; %+;¸ue\i,Q9زudXe ŀ(;,)p')eSNRAvŐ!6,ClY   6,\WX  .+ p @C bb H@1 JbzB@ @$4z`Hh(@C@=AJzH(H$jK^#׈P x5N\>-.+?\Ww.w| Cww|_!(s⻾Pq])Ѐ!#ww|@Jww|Bs⻾Pq])Ѐ \+:%yWw+:%yWw.w(s⻾Pq])Ђ 9V\Ww\Ww+KNHhh!ͥw|iq])Ѐhh u)]jG !v+CtYG5HzA A @t=SHaiփh=n4!(un;n;n;] 8i wNwW<n;:\ǀ7xE˺xsq܁7<Ⱥ.;ǁZ[uxM/O2.\t+JoO1zyr0<ȸ`  x@5 @5: sj0:'CD@`@C@@@1b1BP @rP% Ā@%  dJt H. _ ./tBX J..z ]Jz\.` @ ` B@d@1YTʇpBŅpʸUYe\p*W pU! \p$@q\yPe@@!(+wY 7~>}3!YBPߏwd+  LV@軛LW~>H,r.ߏwd+"CBЋ||w!Y{=h{^KA˵xo2^7A+ЂW]M+y/ ֌He|!(41!І@ b hC!!BPccB 1`1`00r0 @!01 00`@@C %C J b+H` BLa$JHbHp! %W$\w@(H)ð,@awv  ]ZBBB ]QjWav_(P.v_(k| QY](%Wagw|⻾PJWaiq](.+\W KEiq]('Dhw⻾QZ\Ww!: -.+w|BVw|BZ\Ww+KIh.-.+ hCz[|+V('C@ we|-+݀ Ah1|@40M|Fc BPcW|Gw1]^LkgjOH}gyy/';3<ψ&^Nh>#y/"f|G Eo< .^K9y.3<ψy/)S ͟G|}(@B9>QZ\Wwud+ VWw<2P]](.*TVWw+KT,.VWw<2J Eiuw|ʅBPVWw+KT,4J.-.VWwP йyWw+KX,@ yWw+KC,E F伋Kw|"Dhhy⻾P@o%u uPQ̻B 9hy/ ! cc4vq܀4 ;¸+0Jð;; ۨvv]Bl%\;u w`CPv.\;u w`^NCPv@XyECPlY.Aa\`,XvX`E E!C(p\Apq\q\pq\!@ @ 2D` r0$)r2` D`H3"` 9`@H&J! 0$\wE CP$q\5_  |!k ᯄ_  d w1]L\W߄w0 Jb%Aw1]L~߄! E߄w0>EX+|"Xx,[-/ǹdޏfX^70 Oz=Aj-V"7 !>xN(1`41!1 ?E|IGxѾl b /k2^ӥ} TsD)V}Ow/h} :h OW?Ce~U,K+qq~~^iU,K+qq ϩ?C/Gkoz=}4Ged !g+ߣ2{G=GeЎgBxY ŷ OQz=uf1,xG ?Xu=Geu&788XQ]=Gez#p=4Ke~~Ҝll,o;S~^hh:AԸҽEJqqPW}N/GSxK#Ml^e/Wrn z=^hA__ ^hp:gu>'2E !]SK{HCgq\dd,ǎӧZJ);){Oi6,^)USkW=ָX,4Tt\X,; Mˢబ1rMˠ+ .aX`\X 1  BPC%C @@@p BLp D&pp H0\@W\.\ \w@ B@0$ C$H"ðp \.yPeBf@ʃ* s%Q̭pU&O{/6q׶fw6M3ADEWzBо^b UEש%~&w 3N8.3tO U|,^8^&t[>QU3z/S_s#>S6EЯAaﭷXplLzXＴW^lxt P/w3ײqWۜp-k8Tlީ==B fR<ت}/c*6:xGDUm%N U rXøIԋl_Gk[NxT96O`**R<׫Uq-|nnqh&FF%ꚭmTg{YZ^Rq[[u1t[uike{f<իҸ٦&X74®fD9>&=eF Nsֳ%TmϠ2GzW4+Fs\ŭo{\Rσ'%>n*M<ӫҹ2\4UI8oӴ#[a:YCBTn97%qE>FJƚ*tL)tSӣlZ8)%i{!Mn{xM%ïVx"M=yW3bpU11>#fg^e$t&B6}TF&"'):y]|҉vg-b&uw{o5ĆyA7|U9YYZg)yES%JqbZ9o7w]QeP,W}dzbON\R9 ,Ċf{LV[<.'} "j~8>v3{hi/0@g>gy]>&;geӽ:wkhV QksXV.b PZ`.)G3Qe: y-;Y]Zu6k*׊iNcj01*M330|J"I<:p8;j®*-3nHm~0}>ӯ3s^[?gyKMw_+5SoMSN*s<x3l5_ǴDh ѳD]QFݫhLGsm㍣=Ӌ:Dы+`uYc*Pʞ}v+8sɪUxUѾS,=v|9pvɳb8rZ7ztxT䏗:,ҺqgWmCRIkM' I5CQ4QL9l8uU6v=kcZbb-3x~3UQMВ̧q̭=ݳ_#+ޝ()]}`]%u2mŢLLN%{iYXȌy{oѪ xAS,en~?GO#vϙo4U3eVˏL^h;YV6f:؋Ƿճl5hchU3g~qOܑ^EjB׉-4Lo3b1z語dNd٦Io˻GkLkKt>qOܑ̱Tq_nF^wM^Z.7(e'pЈW2bfpp)ū-7~0?f7[V_|3N$'q0X).Ujj۷ЏZ[/-kW̸K_,ۡU| a_-OyIR[ W4U|{FLB.%g^&3&zAc38(3F+C`ywieZ '3擋^4i+^ww ܤ~佦OkSZֿ^>s:&%$aW;{67/lx5k6(֮rP ?X{J)U]wM׋MuG#qL^))LIWz^9nb[ :?r^ӵn7G4QI`<'%SͬWRcJҤb,ߢ_GNx)מ7oCx*< mY.j EĆ~GN*i{uDd.卣gR){F_בҥ_$åO,S=:z^8zD۝ۉuvλGN{cF&+rtӎh4H_q=,8X'n&5)Fuͪ/y׶٪xK*J`bӾc´Nfp3hӶr%ޅz(nEʥv~?S/Y99yEZL˽,.)ԝ9A.˚Ј^.e_ib`,PXvbbȃ"M,\MpQdرg<nj*kTohӎ>] N)Y?8,&5y]Lg}WuFouS+I_Rj0KYCKEBscK71BӇx7)M'@v)SI1Ba`$4MsLS̓HW} N+]li"az'4U눙rW<ڜțD)+6'=R91v:{LL\IΪk։̭x53G4*JRR-5=Jk9En7ҍ\kv΋z7_~LJZMu1;24E%&/Bv覊+ҭgg)FMJDgbLVЕ&Rv]qn)KwwZƫl9ȪV×k٪'Hs5;NjU1<٦"tU*)jcŏK[mjY'ԣM3Κs"'#s_B-tN(cwl8L&4{?TQ^%EhvpG Tk;;kC#Ia 9kf]6=4_JzoJ"&l4Zg[M/^4$D:h1m_]פsώƬ+K bw|4qi*)m.1DDN_W^ðUrzefӿ6Jjh޾$cTLW)$9ͥpt%RzVZ%ޙ9yQDMS<8+g-z7C4mTyfղi*7ܒ1XK>RҎ|t8B-կLw[yk`1paƱ:hq(Ù7͟m)*Αm&? 5QD_H44| Ut;(yjʝL3r牡 I=mk7Rt=j4Yn)w 9:2צue2l8EuE-~jyxUg.$M116Z,ꪘ5ڮnKgż!*j1OT =xhԚ̝]&"5~aضxŠ'kIiyc]ef9;5kzw=JቊlHڸBR1I %Zj]SS&u´<1MKq1xiLs>SU5U8S3i_v)WTEo>Գ1D2~`jٰbf2Ue/MƃɴBItT~cJ+[p6>JT3h[M&ˉU﷽y\3yÙ4De&8Gqj/{RFEE,U/`IX,H+̀J,SLs;qfU)ӄe?p8uZ_z 5S\%>8T`ҴzWkB:v%fMn%=rbޝDLﵹWS2&/:hCʽÇ2zUv]a)b]5dgz쨢q&#H'֎'mlYNjIEw6˧)&ۼ/h{mQ33wꝒ<8̴ki.mP]mu:K5u~ 8.ݚ{ lQ5BU8+<^H(k/`ͦĤMKxR{Ak3HuSfw'檢4¸VêlaB ,sM;5Om 㯯^YFڼ®)՗*mڧZ/q`V]/Нz fc4Ν6>V4o,&-+K˹^N˼UhYO$SQv!S"ݦfTֹ*y4Z齵OFgRVgi ߣe4$- Īk.&7;Þnk]t6N+ԼqOxJ]h EZb#e^1E|WQ՜Rٽ",JۉZ̩дդ6ŚpoLkTC fUe< 5t{8 pj˶:0"btpy9ezsW3TqkOFFF]>jjgU%ti箛:*oZ鶍K*m={>)FQyڎ"uxejcT^;!Th3f|;LJx?aAf|,σ{Gx?`dZ MK3?G|\sSR?@?@= =!!h-5++u떎xQ- e޸s-:xs-:x6\s!!ز+`phXv! .ӛ :L#%g52X|ٟR4tzW浛]oB9(Eg(Fp\LpaNP{άç^HygF'L ,ߺ}vugNk9*n*ŊꧮB)(mĚ.rݞ rj̱mxgJsJ#%}VSC7QSUq^'lر6|N.fҨJ}n,>2 +vNjwm$O[!G5R6[DDL =e\Zb+һ>&=yb/6kba;Q7md4dv#,ջUVq+_s+7U3Di&bzw:0|)jV rVoV{jG'þhzJUNwԕFUeQ]4{VaMx٧H3Qj畫 >i,/t9b*Tզ:"Vj0WPnuE{DStL-Dsn}ߣ_J(jһ QT)ᾪGϕ&k 8]s4&&ˣjš6ݭ**m$ wiE"HEj]/䩍VPyr{Y$I0sqw?^tLx4޻(>1QU6yoYmEQtz%wv,+уR}ŒS޸n:Th"-fMX8ޝ#ƬJ-Ȭyp:VqW6mݫ[s&ZڷCύyM_Wqij(ז{ݷVmѭe;,WLM=t:< 2nbm1&&Iɵ/3qR鸩עKhi|#yh7v=4m3DU1\{vwDri~g3^&$語x.5RO(ij2]{>u)[GE*MEJ{3L if^9vj蘾Z7[vx5E<<7|<>2&*TR9WMR(M5SmFQVww)DO8mj)DκoxX>ˇUTU^$g"$u3JWMKj׽8vW{K٨1)a˜aE16vUV\3\|-DL͖8~ir4'Ut흔t+Y>Y&# ÍL/nNۏj꽧)Dtۖ鶕x7J-mv2_wޗ,N*m㻂ΰ5*鶥JK}gD",ǂZݢ)y}ѿWœL/QWFa]3{,)px,11LssJQ\vVyO*~٤uZ-4)N7ye6_M_tn*լ<1so i*w9X  TyKͥ¢~[^XR*z1n}xx{fiY䢣'ٮzsҞ'%;f潝V,U\.ZZq,WBͨ, /]Xs&ҜDkq cbݬՒ=v2'QD雧 +e5d<16{ku[fK^hybNjRpJ)J];ŋ4Z%YdË+1\ʹޚSD}ߨ1vxvJN7o2~1̫31xҊjRmITѻ~B'ms5h&־\6 &>u q4E:yů&{p(Zt:qKs<12J+$oUhrVkN@TKe֙5j]Bf4S1=tۖtëbes$MϧRv] b9nԊ:ZW[oЛX)}mf*WExM7˯/ZQabTLS爓ZknTҖ[㝧R5g֫ƫ-mV]SMzhbf-UyfogDx\-NWiE_`^xxmVVWF QΜZE&fSM5[oN_g+=z{܊S"#W-3s\zAlz}f]v8ciu-u4{HѲ[ fmNUeK-mI7A4]bqUuՏNmU+O}eqMӇxS{Y%-0.8td1 *Em:R[MA-x}\l\ҳkEQS^͉3<0½$oqU˽hF]aT)7am颪7ܵ:rRv%;_B'(yhܛĢbܼY/ug,n3,DNB!ҖmR;u޶Kx-xٜ8R1:gzQM粛C,ji#]!n\MYfksrcv_iArUII['K\-bVg6r9pv883Uڦvi4_ٹDSodm-lVjj۴z7k.$xj.o6[Xm}Ěެ5MHNRMJ趚j$nGJu}6G RR8-˥2DnȺLQ1mQjGׅSE1ͧf)ØK*99}i80^ڊn< jNI+b_Ifp4U<'aUh 8w: &:oy5 q"^^de{{K/y]>'NGCϧ{mSY0fGF&YB̀9e] i-& ! "Zyg'tZqGNm{Qc.U#KzѕԢ׫zS8dYv^| x=XΛnÏt1kt\,<,:0&b&יs{xa0 ]=.*b"gYEƢoW{ԭVu,kA1˯NF.ËM8wmuXVl9]\'FM7~CڊI&mt~X4ѻhxZI8_<5۝S]k["p=U4Lo[{h0/=M(/4{w.ktrХIrZitK39_rPv+ˍVFkYn™/6U=U7{ٱ)˖(Yuo ST]{PlxG{W/qΠmǺ)*idq= E9N ,UiX%\TcgO#1śUyFmĦ&b7BTt)r*֫]ȺOZX vȵLUSTCZpǣ&כOiڸc霵MU?`,_੮kJȋ^s)ݯNbª2Fi܏ ڋjjK[;@ ` ,@Hmܜrk~e(j|BdK_N<|fїDZjuU5Fv/M6kYp/WKQ_nnViua)%w]UT`aDS8ox^t3DFhIFnhv>*gaI+6K I.WEq11lpWDEx^58zXX}Q'oq)S'= oMKZ2O{gUުq.pX^9m*Hfwpes+*𽝣iJ5~Hy{Na{xc%n3{G5SRq\Pc|qךR%QV4]kvσ4a5j=wN>XΦt̆I;zF%%+^/wFuѥo~0ʵH.E:Μo~㩷m*#A1 qU_>J7!ZIq h8v1DZh_YZ)*XiOEQ3KFr]nޒzhRINJR])#*fric/sӤKGi13&(Z=2cHԚܮ<+w>6N3inZ;'ULyMcUDrΎfJ-9{)&wұS}$Nvp >EZyGƉΈau3Q-\o1)f-e◧6un._8VQ<ˋduj뛯A5^kdJ9⪥4T< أgz}HT2~8ui| қ48#|(VXoLeՋFJwm]^AyI%YxɌ9'n[皢'0cRp{"'JIbQ4L3=t6iL'٬Q*We~+R.Y {8<+(;\]o2fz&ɃTf<Ɗ&/2vlWNki΂SKEh:~ݝF~:rYvZ9Ӷ=SUSڋG~XWE8)0{,5bb)GwG5NUױ5;MPfa{'5{S[LՍ31;gegtzJģiTn/ggb|VO7i{LNhFU35osnn9@"gWY3u?@&ŅWV|}^h|}^Y~`f~E&Ŏ k'uOWPG!-VPb֡ cc!(t!Ƙw2X|ٟ֙*/?Yŷ/e_DisNͪA_uާ8B0Ylz0a;:-tCgc}wF TE}$ag&4ES6]xsfЖ>.YRWU)b#N4nRxg8Z[۽՚k3LU:h~N^KJv| &6Hɚbw5TZӣGkw)kMzʽu');Kzk- 猣7,LD7^'b7fqLEZzNh<7>6W4=W84j-iѧ_O5 8UnʬKEjz[C*w˘k1ڄ4ٶ00fZj0qpbfoJ0Ī7OՍ s>ɩa{$)QJ mI-nרgӾD.z1*1ţŮ4v͉LΜi]U6oa78t[ӭuۈTuyf:JN6JoL9ܵihgtw{9usQ4嶼Mn|x1Uri=;C#t}v3^5to51Nz]]3M4^c̾>8QLLƾ*LD-:*:ܰNR^{]'#2p4~߄)%IIwIBLESkk^s*ƈ/9&f# ËL+^MN_:y1XwW EdT>tZ^4%:n\]kĘRbhہFˉ17cQTQmQ6ӷĦZq^I94 :V֮S-Nҙu/]$[HD6fb"fg;c$DN'?4<bY`====^|NNC OYʁ:t@ q\S'kZߜ=tRzKDF.iJ $Jw۬b'V]zͪĞv6~1)٭{r#Ub׉L'ݱDbӒE_7m8whljx4ŮkMk{mh';-K)맵ڣhw~18lwLeg&#U1xWiU1i<ͯg'֩#8G>==jF*+.]'2~{<Թ8nz{nUƾ+&DY+&537k3z9vQD8v;|٫ai[-ΜU:T^[;%lT˒YtwVV<؜}YSӶݓ<Зֵ^z嶺_H-?n11#56](SٰiN^YwE;Vz"(k1[*F7[u$ (Ч&v.*UڜtZ,"JWVWbqf2ٞuUaSLsŷvêL|HOFj]ٱk)߾,R6::;,ST>FRwjn\UiԊwdNIU=QQm_TЎWfՍNTN^4_-g,i3mqq*TZ֘20*&yjݦ,*Ѻo_z;"|U+duٵfκ\S)S̲ɩV߯g^Ies+8-qLDt< Һtr^ԘDSs9a^YV4߫.g+_]ҳ[:O7 Sk{~_ *꦳{hqKӊ}ʵjWT:͑{n61?3QW]p6Ù2l||]ti5G'uq!Bqj8]OWk5WQ8[OM4 փ?Mupqgf諮6ڶ\zoݣ=0no#x*0Dw#[o`ՕIU[Re#.lum%㣿a骎Sz~XҜI=OS}4r?OU^\ۼ/Mk6,9¢fתmۻ5 VwZYlYI5/ڸen5ܪ伤r+*ZеlOk ',M紦ϛg-G_1"sDMvzDox% q|R*uj9K{ Vk$g|F*R69Z0(sLFd+6^ lqb06ߧnM8vnߓxOee4D1j- 6\.trGj^j骕IxQSQ+&xG~i6ʪFH- mcWVby`a` $QycyP鞽e/+<= r_?)dWPrF3WÌLz}/O79]&jY}BI^$/:ܬ%0߷pYca6eb2Vzŧnr\/okqt30M0&6NKͫkH-a'Qߑs[/R>dݫhe MSLϞ?wm4Wb',~  XuZKUu3S1vm~hqxTWqFwhSTgg%h3%;>:oNx峙|9j%W *(yMq)V㒪f"LӅMSL_1î>K}XL𪦸-yhT5B5S{/DZ. f%4bO,VpYԪ>tK2}GU%ǞbƒMq1E14k+׿val4LC*wE2MϡR}'Kwi<'ʷZ/Jb2y 0bo qp85 5WьQ5[{)Ժ~7AU_sҔ^ˋbc|LIcՉ;WEf!V+N`Thۥu)qIrхL'paTy=DfG/mN N͙MB]QGtB;Q+юfuу1!G b"(uZZikVhZ!孹rKy8˹:Yfaψ^eIÈx &gsJ:ͣk7'ȫzE5NdDFplIi'Y4hfw>3U:4_)VTU]G8caq.iǵ9"t򱍚Zvb=w^=[.Nݟ c0f-;]MFT'n߯qr] pҳRӇɦ Sģ}yXkb׋e|__-.]sɯ&/W=Nd\w<&/W=df.]&ɣ{~` d](Af],˴wZ"sr!Q :wg#GZ6saJ&ήRHl4=_f~[c%_%g8Խ~;.i޵E>=y,3YUF7nN |cVT sRSvzSm30D EiSth9Vg'եF՞1r7 ;% 1=:jݲ0r N sDLLoG>ӳQEU̖rܓ[ݵQޖ*t>.E>&,LDE1qj""&tHZLrQGWk9vi8~,]X1 (SE13Út RNaaq1W=;j&mk,zQLqs3TOkƵxX ZXC[{r=uNz_f!FeCsԚvl|,ɤs<q-Ti<+j(޼TVqܞzt筕Z 94:VD9Ux0ƪ+刘.4Sע޺lE48b^Vj'{2:XZPmZV޻7jUtLSG(xkEi3д{M4^+דO+1Mŧ(b*=F3Qr8}H,:QqK#vӭ&wݭMh 1&:/՝{&Lj׶uv.sTU=uqfc'5s~ٽwx&,ՕZNKSt:ͱNݍV]"7iĮ*+ôƚjG<5ΟE߫gi~Qi$oa([VJ][><^g6IŪc]yĦf/;TĮD["U6uBL1mNZnd8rv΃|0fXqs5wλՊmGNLJۻI5wr76Z}ZdG,G%tQ66&-? ^dz6Kf*sF^+;K4Oj:6o< mڊzeۋ' V8~i~P`==Á<ꮟ];Ɲ@YʝD@bD @>g.SV\۲$okmSU9>Mw#]Mz4D^mf;i]cŠ0n~.]ϛlC9mlurJ#ֽgJ}E"7Ii~iݶ4mݷfN.QVMo"0t$s9¸Xe8v޼"Z^ԧy%]!nRlt=jZ/IZ"t÷`^%uijN<ŋS}csl ]t'O )[Mvte(Eguu nsM,qU9ՌfPG yyjpfGxaU_ts?A=]uLi͓dNtŧ|Lk[ 98/q/ .Xies7Omfhr2S+\yn>F6%tcMT׺9l1x>(6ş -tzKn qq*S{wgTr$ ,viE:x^i&Ri5KĿ5im0ec;/j 0jyybڇl;vMQO=SȲxj;./3qOXW'QDOT+J՞g4j۸c-E=<_jac7M11ߘ>aSLDF|$ٸ5MC04$=B(I~*TciUEN_ؾ&J'pxf1z FljOgm8XaE !zoL9%Yȴ]t%VSnVm8}^;{fŽ{qD[Vc.]%)tJ۹koNLfoj & =i(URmtkO|+Tn woc`^ω1E3?..Yxo m3uږ^.O4WmIPaՖ\D-k_,2Ģ*fnDCĮ*oa$~ƚԙ'=&fitQubNX#-}5-+tb$EDNx^hc:8&5^Yc141"#N#ٿy^Zt$RWwfYc7oE!F%E8T[8$HKR q$IS%uBbUUC*Ӊe39]Iqq%ZUxxtَwƭܷ~æsaΌojmlѬFڼJgffS4'W~»Cz"8Zlm'W,a]!E,eh9>»Ae .d\=nQ~ܗ^\e /Wup *o۔_%yEtzuOU֝<nQy/ ֌(\Xv"ðñ.(B@|ٟ2X|ٟR4tzg]]M<>ʒ}HUy_t=ߔOu`(5W,JXXB-SY^tg)7<5jU=z^EJIn3ۗ<5D9v6F=Ӊk9T`сV_Xӕ>cU5f#KK{J5}熝jj]$]a] .e.XIѮ 0i4WLQLiN{=tqT"$[I$AFm{Joe;7~hx6%1e1Lf,q&'[Drb"˺g's weݮ񊋍ͥiӒQYa8M3Tػ:َISΝ 06JicX^G>Sz"|KL_ kb$՝mo+kөh"Ky3\SLƺ{;>х=TlQd8򶣛Q"kd=U"bKDC}5e~gd&uU4EIs4G/GnQw[I9{-O*W7ѭFvኢKbͯ4&l:hW6V?h9S_QQƺNwzJS9%:zt%4W:ޞzʹ(3S9.31 wD#8A?sYԤʯbH8M٦@E4]8SExLvVhůh"sMj≈{bfxlpлMہpZzj~a<%ӳM1hFDZUbZڱzHJVѻYokef%[ QE13;ljļN[lש8g.l6E~ v$ګ CȕVRm=}gff"z!Շe{%{]SD[HvZ)jQ}~885կGCܶ(Z`*gojSw4^Jb]HʛzN~ĞX vZKaMupH}i/k0qďEO?8Ϊ:6:{Vtkh0 @1p Mp*-h-ph4a屪O:ҕIՅ ׵➫IUokM:W0M6K~ٶ|,mgqf#fӒ"C0kŊݾ=ESͻOCb&EFҖV-Ӻ:yEK,C-Sjxk\UEDՁDa4~'v܍6S'p7_'3מٱ&:Jk/m)w*:t>C*#I\{뼟b`fԤ۵[iݸ-sDOG?q1*q#5&^M;UxSls98gq&&c“:I_wYW%m_L:.rWs=[$P)"0ĦO';`SF.UQMW#Omt8:[-m«i&*^? OiIA+5{+ZvCgpXdJhq)^6Z8 vލ=У{&эzmN&ݶcU]NolU\eb-UHrv0&7"ڳ*NPqd-JEJi>;>+GVT[?66/5t{WYZ4Ώ?`Ék33xn87y츓cXDӻ-]M64X>mh?ʦ59^TlGN=dͦO,„r&{Uh6ZHo_fsad(zY׮u>v~213iiF/uMs]Y7:h%y/uҝOYiN+MEU} T{;_6UӯݻjkG=xS]QLڊxrxtyLbۢ}˽. ez#tGn=};[]1a}Ū$5]Sζ&piwz5-iRgPq 55$r#$O98;tob46h&;|bWb^b5L\LUMyvu%VRw=GuWF/ 7R)wtA6ic$,grf]xSU_M:ʢ/i{U;N`3~H9il舵WvlNiJ[=^3X#ٴ%JO3]{YPܴ'M5O.&W՛i>Ym ᰲѕx}_k~7ɦ#3~ji4T~׃b"7z(?6$,; `°@ ;-f}j#Ac;SSӕ_}1\NG1Nm|pmdxUk9(-u-MF߯q85inZYӹY+s3T{]S8G=5󧈍Db8YIAaF)¥wHLJ+f)2cbՋ13ne+m$mwqU='|QxY: ~FC8+5.J$[j<(NRnײta5LͻhDVoUE1޼VѥUGgn2U-5ס٦o/14ގږ^V]lIEGG{iN 35_YE̺S\2'1x&'6w m8Wiw4)1ļOj"owVmsEj5a$^-*gUYy(f/Ṣ%by/#fmixA5/`d^ E$\&\CMxK.MxKue, &%&%:!QKy5/`5/aՐҌ B̻x/`B̻x/`hA+'4+ HzQMMMOA-=4z @C%}i{gߺ}9{;޼(կ0#)fExL=y|: OD<#ޞ8q6뵾Okïi3:<$Q1}b-i5%v'mx8tUDe:VÇ7LͣsA?8Ϊ:6:{VTmy0 =g*Qy企°&^@` M+6TЏgcE&FiIZK]l)IߣE}N,0m < jbc<'F.Xb#J)=jX2b xIVˬz4aR=w̴ӣCʣjY^6},(b`gV5w3oIĢHiky]S7JNm*&oۅ6ZE5̃m9ZR GK+4:m}UխiIyFi+n:;FTDdWM8L^o{MߦL.O[U:,ШR+n~WKIO*[k5n%Hc-+5̿ۨߧB"{UTjےхESG3&ho3߬L]^'߬Dw[mӕz8-8%׸ǡMLE5Lͯ:[6֍jģf0'tFB*gXjgWFӰlto<~hOR^v o8x1wY޿mLnM5V8^9<pXLQ1m9:eB(=ws|zj-V]c+`3K C@ @% S㉡^[S靽 E[8ӅUQ|pN&5q j:wq=N]]t-QꖆcˀNu%xb_ï7i}&4:|IÌִN4Sť}PZF]1hʎFC!84]k~"ѯBaZ5mTbҖeTMZNOi]|'8N583JzզL2›SdEW4O/+8-EYf񤥡RSrVvqSjɻhES zI]Ț#VXSMs7ujo+l=>wVN9iR.Tr>Npp8ZRIxsڂ%jKaq共ꢪdS mU+7ȱX KK^F߃YtnLB"5«<. Օf n0QS{pf̴1feaFEsiNT㕶1muk+_/j4EDXTUwWe}mkq#[3i;_IM dUmb{f:8h6RKRGЈեRႪ֖Zc5MS4UNE lyp"v3E1k;O+&K69KdF[5[ [%ʋʳ*BPo{)s%5D[8mF8NjbG&ТVߑXMSFTչX6}R!Uocmuxs?d.\%:m#%Pex_s\WǩC4rlCigee}˃%xc)~a{uu=*DS:OUqx,Z;ڈ^FŴSMxof|>gv>)5 6zm:D. b+s*iD?90[zhJz:gUQkc6ZS QFtTUNaWmϴh^ffihteWѯɵ6FJ5;լD=ۦl\ks[NF6"fk0P]=):)t- 6*LƯXMZyظuSs[58_%9R|J:s,];rbV.$Ut5ħ׌;ʈâMS+{&prV{Y([qqkqҪZDZQv1\S7"Nmj:kVSLknkۜDlSV+[ufS_%u`}BEw/7;m&"S0q"ĵyf&cD2S ܑ=忤'UuUqdŵm538gY57/U6-Jog/iRTYe(mViRZe Upj\LkJ&i}0f:хuDY*JSM{RI߀O,o-nGwEyx5S='7>c2QM^Z{{N/ WRG4uC*)]_9K&vqm}ƸXkO.cmWk3jaIh%ivXy$;#WTporKj] +w: hO*o1nx v~hslӴ]:^t>ּ!Nٲbjw!{{M{{K<ꮟl죡ZweNt4 1BPTӓ\(=ul.+կ8k^)[ZUb"w+'"͖fîW?ax{=tQ]ӟt;`Ūo\"޾KXGEnFK?Me!8G8\Z"eO*Mp"i-:\OQT;iVvjc|{^.ËTMS1<;]ҟ.\i`{EɞZCKo HݮJT*ltqNۧL*ѤΗz\W-m:b"yAtZ5<)Х]ɫV'4ߺj+LxEpq0rڨ/UN7=[N-uW5Z"4=)ī5qɥcZcf#ݻI9+|$ԡOM9&RKSԩg%{Va[ڲjtIom=T1yיǵUcaLU3U4]YKsݮ2nۡ!Bumwk-Uu jiĊkݻi;~QLeXa/y;MEuS1To}fpq3wvآjz;n=l٫F_ ]wF?;F)TeK5VH)o`QDľsX]M1}y:Y͉3߉^щV,zІ"9egђ$M[TBA{v"!abׅVjfpxC=yGlj]TF(*$E7VP=t$6-~ 5yfYbߎ֣4ܣf-wx[K{n٦OqnecQMxYk*cg5VUtUoooԉ,E۱}f-W6Ӛ&rtڶĚE~o0bDvr%@Py0љ.)jq[Ue/Jӛi=O~VhĪy(7<;?Qe )9-+vg,itQ̢] ,ipUywm[U8U5o;iodC Tj.;Eq-ߛMlEayUȪ֤Xiի)%Ji4sLjpiWhRۧCV Wtjrn[|Ed^J{^\BmxC}6S^xKLD1&=U,F1cQ$wmz Q b׹Z!^ffa3M[TW3t[Jˣ~+n; Qn//wM痠^7!Ys!ҊmkW\o{&R5Dtx16kFLhgs)ͻ{bg^e9Kdrd!S-VFVޕXb0YF4 cHL-%Ts<~y|*Wah4[+<m^m|J{=޼>Y1:_[<}fȤ:aW/οIG*%!@aPkHnfq{̶ՆZ$:viJ&“6 (^jǩFѰ,Df,}^)ӳЊc((CQܣJf]tף\v$1!;u 4Ć@fK3%}-u/_{* sNKwڞem4k^$0RV_"7uGD<'ߣLlSMUZm15LS:N<UIיыn)K#W\:VnPO-%V 1=.fT__686iJ*}bh~G4nQF6GZX/wF!եM3J*f5R2:= hfUe6ݮq)޶KSȷ{78՚KF,^>"'(:5y9;SN^ Ů*êfǴ`уMXtx7i.Ȇpi٫wN֎PWD0K"g{LۓM1pЮUSϧu * k .o9bb*wFSZ-]qƪ3:y;r0o3Gӄ<"#]ϳQՇ<=դZ>'*o׼ykJhBaE1{ݦ;L[Yr:Iz&M*OQ)K{wVvׯl|dJ۝&]4szub䙴Er˧f٣剏YQNmqI'$D]F/,[=u#Mb#+RT+uSTs.m/hQcWU!\U^iU:7ÈMZOy[vkT7?AUixӧʎ2Eyt%⪮&g4mW}ωvzJVlϬQ3nĉŧV%.Z׍7ᢊg\Smbzgb%Vሩk-5ׅm<Sa4Sx{GAy]>'FGCTmhaN =CSrrhhW|wQjZ9]֢ shhWawzPh8&٩zf#nwU؜&7R}1'N॒6+NtT}Ф:eՋ]ssk}\HĪ3UW.^QU4M% `ר-wT-TIss&f+3kk{&݅UWm%\gXp.͟Z"mܟzӃx5z^-[rkѽIQt^B5NЧyda;55L?+رggĪt(TRNEٵ%ith},V&zg5^QkUīJ~6[ͫ;ÇWUXuqbyOSQm/4򻴵85[d8MӴ_Kn2u yUV`UUBvL<(b'4տsnk)/TkuW :[彚%xy_DZv4;%FMtͽ;DwCLmncחWD#7 |lSWE+ 2] @`H BLyo7O Mƫ4f{d62cz2?C-LUG{KLuU_dEF) ]+4L"MUjkzF\Dw:tYma4Y1;:Qxz>lDŴ߈}g柨کKKh 0 @Rv(-SX<^BU-55BE,j*(N]B_R0oq%{ȱXQmY^xuU0"jOUE7=. ]4^9{MKE.ò25~ԩM4{L4]|%MEWlMMirO_hڏ#&:'+Z6OkƑVІp9Xrk))Tέ'('ŵ\ifE-i͖ĢѺg66RjcbDoyLL⮗K;wJ#l92\](sw|t4TG%K%"t4Bsw|% Әәs ٗ9o](C6e[Gw#vx}e);֡ cc!(41!@ }a_=FrnߣsmX5bDYpnՇSW(|T(QXG"K:[K0-">U[G3TӬamTeY<+GR{G+jpǪy;sPqPS`弼R{G8{_?oX7Gp4G#nX(TwvϨLa]!w w̰ݪy m3y9ⷒZ7/ aG 1[9e&Rin{)isQijﳥE5&gL;\1^PDU1uQu*InfoGhv<^jǷSOoމFSiz1L8ggXtW&ewaosjS[j4kG(y5WM3^Hu%̷G2YD҅"k)T-Tž$vn bGwIxGK֦f+ën 9a5jĦbŖj0f\2汙1^yiӲMqhsϳyX7;Rxi~r0g|M5^n6aD;ݎܢwNza !D5sEF%68E.\],̸vR^ZȦ9Q5U{m LL:M޶ DQIY1yaV%SEqngӈM <Ȏ)4fZ!Ϗ1.Ike]S-&KRk;'oY9J9Rz.k?=UM9ḇ'UEψ&.rk2YM"ψ&.rk4Ϗ95w \q"4Y Ϗ98]w9W;'uHA;zE qMhSkE f3F3D]YY(Ѭ!v|%|W^d[Fp 45n H[@ 8[J@ 8N $ zq@!(!N#ӈIAzq-8N#ӈӈոN#VӺZqG-8N#ӈ!n4-8N#ӈ-99izqGt4[NtiZqGӜӝm9ѧ9|#C9ѧ:sst4[NsCӺ9{t_|@;;A' H@! $C  C%C2DJ $ @!`aa ðI BH(H( %.w9'JЪR6SG,l)fM黮3 `2{_eS٭Ub&Fڧ=TM=T[srE]>]sz9tEo$&g\uf1ߎfĦ#{y%Nر7ɯy3mQ]_R uM1vqUOLչٱiJ -qNv+vsN<ū1kMAh5YՖ:6ѳמ̚(j"_# )Î?{QLU#YȸSigNGIג{,L]XYZyx3f$n^ُF=Ǟ;^RU<(0e^iul7~6,<É/~wi:jҫخXdNGX荧#z*k+ƻb7Kմ#Ilå*)=v Ɉwr}Ɠ Gࠝpm]5Z(XS}uՉ-:1p>N< eʮ98'b /&i㓏@NiFi㓏rQv"D49(%`q*9(-:PBT(hCzJ1+bW5VQ:@֡V,raa ,;( aa$ ,; %1XvVCVC$1Xi hbðd aYZ Av&ZðdY6- -bd,`b1 X X+ C,! @b@1"!CBP@1bb!CD@@`Hb(  @1 $z,(,a V,`&`P .]z \]˿f|who)"߄xPo,Iģ'U0袻:^1%GW߄y+`[9Ro}$rM#IѴՇF4# :5iA m5>W~];ЉaE_gĦI.hω0hq(-h,Z/iխ"glNjMMK)zNLM g8ANA芒_;C3Y&$KjV;u6F\@~>kDhwNsu=@44Fy,=AwHhssx,uPzSmG?sf̻Wl˵p/uHBZta}s0F0#7/l¦&ܽ֡ A`1`:C9C t4r4g#J `t3:C9C!F dCC 0R 1`0 b0`0P bDC! !(  @!  0$HdP (I.@w `c ]"31bfTw{"׾Sx9⸍a>5˒C. Euw|3JZ3!]])(ȸ|E.@Mt5&RA&Є|EɮBrkMuw|sI{j5]]) -{i=.Muw|ɮVH{}-]/.xu9Mw;iمô08vt/i>i7Ny3cw,ǴWכydY!w9G@Ei`,; 40!;hI###Kh$ta t$0PyŅaˁa`@\b77 ð bŏ77 ð bŅq $̋!p0r ,r,r a t`tl7E+  VH+ V @H @C J!A0$@ d  B@$J @ 0 BF@zA 9=Gp$4\P4 BL0 H5 %j;5 Bðj(e$ GY@!(-EՅ`J Qj; Qj; Ġj-B`  @[dž/5 0 |Bψ+># Ϗ @+>!g >>`%g,WV|}^ >"|}^Y{ B|}Ag|}^Y{(|}B >>`Y{(Ϗ+>>`%anZ @X-x[--x|wHv]@nXW|}? ?Jl{=v:Mԕ.?)H![NiH;r#~b>jݍWy2gAOGӵ]w)ݦtD<;LZ3`&֣ήYGō I@4+0 hI 1\wW!(41\wvpa\wi iiM@ah=vbƆaZBȲtF`h=XtFð,X-X44hhct,`p M`!W+ C%` @X,aXb°,+vX=W5RI_$L{i71ܕDkۘ]9 ?WETM-(@°T@X $@.q@\ \)F . $e./ʼ%.;y>87ܦo&-1nȜۯ=p.՛ ^몢2|?iyI4Sn711ST{Ҕ1/+=O;yiϝ2˹ ׳bS53iӣAHZ*XC1JD_ƠH3. H3.Hf]~, v_Y_ JAg]~_ At;('lrd2mM3T7@Qjd?4<;ypԧYW{޾ڵ5 }M]A*b'3tU&z"Rse; /T`זJT%¢v_ּDULȪl1ghĉiu>1(u.rz_(Qr]} u_ (E6E^Zw|u?`w|׏ 믹:~ Mc׊EG_su&ņ}(Gu?`4LY9H١kuu?` G7Ȉ} F]P{,O$os^NX֭y#˹Yq]w5go =YHF3g(0f#&`G3֌He|@+ J!3$c`a A; v`;³ðf Y&aacH+V 0Ǖm% 2 MWy_ NY2+rɖ@va(L+ e,Qlc@e@+KH]&Z@ЮIi+QiB@Ю&ҋI.ZS` Q%q\b bjTI%v-}*s0)+TRƯjb~O 4yZy6%dN1U-Et%m;luE"&׮y#0pxVF4DL3NύzfM=Wa͠Y>66eOeORRVir҃in݆uWUz^aS6FӲbaDip2 8QU3zy&Z=jTO败}'gi3C"bF7x&i-Z1\!%C!dqIbt g6 @i&).q҇'a?i^ &ãZ|_5\{N4`ؚ_=#HJLfZqrxWbLJ۞Yς!E9ad1 3b;!ub>x.c` .`qXv ;1Xiήsa4l4!(uqð\w9W͇`:9 6k_ ð"ŝkHuxo9@,snXŝ7v"Ōb,`+ 0,`,."ňq(!CW"\` ń\b,Y6MEeXxv?7 :*:v-ڝ}wqM3r%k"cXyv-7տj-J9==w[҃gbO4T<4S\5NLS8|YIa16xg1xkQJN}/WFmliK4S≶4T[:NJ)+FSװE\M13[ax*59v-jz*wͩ|cFj'lTd]ѮAi>.]UPΩæM}:W"M͛KwNyvlҡ} }mJGp3Wwۍhy^s-[8QEŦXgyTb;og&ݗ6<yM6X4ikeNү257}_hV+`fi.LN6 LКoVx|S6W08 $s>G aE80oYڝqBR]`@݈ wb JN5 H,jy9+,> .Z'ROcV5~>5V/[:;<[Oty:C ^[WE;ғOOGmפbGM,ۓ6-oW}mEZ%q{cNLvʪÚq)R4VY9'ang4&xK|]v6ڔ\j^.5ug}:B9ν8&'oBtztbF.U}mjv3SVxs4w4`a>}~VX\S%c*~>yWZqG.K>Rn"mo]F_յtO/1OPS_.öLQW=(1u2+%QJ..jWȬg,exGг\IZ4UK[+7۹OY`sIijⱪXVjb]SXkah SbAᅂ݀@&N>H6,/>xBH-ԀlX^<}&7Ym-A q[M4Dy5^g|6 mT:O,N=ECE}?)@]pZVCE}?)ׄ+ LKE}?)ׄa(-n*w;`@1x\@E]@x$+@R` X1` ,+ɱ,#˃&wˌ#S_]?hۿe*ͬ4cc^geV E+v{0Jh6JemkIizjhNp8N(F[̵hm<.*)Ei:mvEi9-bpП{Y檢ivl:q06pjiU5L1:陴O$5^/k QYIj Jo'=q54š,r<Ǒh+Tj^yVp3Yb 2՟ذb8vlꕪ,אIŸGW_|.ދQ (ڊt[,?:E/bC)bر\.,Y{pe.H.Wk.5;9K^Gb*ycƥuPDev5+}!vM2,<e֟I]fdmjT]m2a۳mYiTr:0SRj1xҒ[nGeЭ%h=gh,T7ey#e7ܒQr&O 5GQN&j'=jטﳯp*&4pazVyUӖ j40=~wk13mLLK:U0ښ{1XyRδQ;%i65d2rզ5wS\Z٭icrʥ ekI9UUNsW9M>~KƏ>+Lo+h^XEFY*x*ii=ef&9v" iʬu"[cBYw9<[s9#sªiĭu%j5a^)<iцΩm,y" ~4Gُΰ/NP_UPSO5>9rl֯Cm챈YWH>nfEAq*ŗc/YW ʸ,)dmVӇf}$򏧽SorR!iN6Jm/1ߴU;TS1SSnNnｗq~&{>>ʹ+YudN.2m#״:G4rGr<:iJK%w D .Xv9Hv,w.C͇`":<6MDyD@\QH$^9Yzƣsa Ccsa/Y͇`^9ń:5sa@/XM u'Z8طmhy:Ň`&ݲݵR'ZNqa؁9{hAvr99:T4n&/FE4MYR",a^2S^)SOӉwɣؘ7GD[^"6cM&-8ڎ:cM& x:CMbPR)nZ bf&"qc}iQAH"}&R_Zn%õtw;ijhÿ/,8kp]1*DXU7G+ vZK<.9XZj=moh+]M1뉗5niL-w[Ov)uv-t;\ӹCI1]T p o~:OC $+>K<%ZOWgg8Kk|KGcx8yc]䧎I!"HVuGS1<$mGS1<$mGS1<$mGS1~o@N:eb o+? pU"ViӃ"D^:fzya:?/iJ٣)k+!$cQK4YMu2- tCaN2.)b.+l5Ħ."s(Z*vg%w*vپDzZ.itYe4זWU)񘗊JO} Ԗbljn RK"i¢ftyU5U*jLu',TYci~I`J`m{D|:2SdsL>CI$]QsɠTVuElG<MuEgTVsDtm+b9ȇ`QYƼ%i=m]=]G*ZapfXm;ERTİ3jM:rwp֋JNM|ӧ+ˤfT)84ӳOCp{8-8x]i9$bhUu!-oC .^Oqb#RlsQ5Ѿm8Ӻ2륵3tMӥ̋k3Q{q9;<힮˲SE/7iڪesxkRu>ڕBK`5?^N}CS*/f\=ݪ6l;]HL(aqJy汴Wm5r Ȏ Ur Ȏ Ur.p:7GUW`9ȸHG@U_hL9#,0إJVOI0Fȶ fݮi+c> JiZ7J-F,Rz~-DfƧb~掹i< ]Q]MmuW5D3~һ~%XMse]1W]mha3y_kSRxIEY4ێ8?uRM=knhڕ4FLr-B[jV_X]{= LV-sUt:^쁬?j.}vDW^&+]|Z'|˦biUuMl~oxp%uMgTEx6 R 8mZEDDuEgTVevL7&x9ڦ҄&ԢH}}>џfm39ԪDέ+b=x{U4(]x5>Q㎭&V6iTS"Lu竪#JzygIJɮXh9Bf^aNTW{T/N%xcW7K46&LJLϊ< upT!e].qp%8\w \.֣tYGG'@BP!2!!;`q qCw!!h%0q+1\wܹ\P%1 b b @H"Th~ MbbMqLO$[",7 ;f TW/ *S6ULU1($[ji}=瞅\JJ̭3nWbbe3D%xJ#>Jٗ9{Of ~-f}p L]׽52/%9~NbY _KH>LPk2{ס. q.y8x4ѯ*Vf-@bp:RM5l#u0ל>痷}lR8xJ2+I4Cі|Fӱ3ӌVʊClH?ez~jG]Wj%59y`quK6ϣg.{,Z6gkJbݖ_S>kïo::+R|&Q:p%}~;ft*Q]lm[v&:о4&eGSھ=i ^ɓ KXO / bF]K*bwIJZ뫉YObcF77^ɷl-4gXR8BG)yQI|2Nrz j;cU_$mUyMԡ>E_yS?Ǜ#nG<#bFL´F%],S%<"Ɯ \||ELVޯz|/&}V;"Job JPEz Q>âfyL:'Y^H3IMM=_k[z>J(EB (Y%I6jDrBaDh\~SWgҳewe2 a8uQ&蘼X_#E'"+hsNژ6eLMG׷хg9gv߳:8'a Jے9gvt&Å;bi3hf|然Nǫw$sG${|LtO. ÅFX^W].qpBes%8\ ֡e< 1 hW!(t$rCB 1 bq1\wWcB @sqP:p%˺a.g9 t3.\,t.`+1\pX\v n@;  %(HTHt9@H^V"jr{.;v]1"µK՜1FŇ:DDۛi^Cі,aS3i.8\Y++ʲs T&Ps.qp֝#r>x,g7:$1L+a+0;4q Avpa\w۬vXJ;ubCq q q ev\E`h-ˈ+-壜c+%,,1 ŌZ Ab-c\bC !6@! B`!dvqxp @0zc݆rC9ȫVnSmsqT|nY߈0nK.9fe +ʲs J.qp$ He|441 ƅv;v;cBl1]1]6 AWc.v :\ia(y/"]y/ ayQy^C q;ȁZWyޤޢBר@va*^P/PE14שu50'SP4Nh$:u @ЈbvGOyK<~Ν1 @1L]jИC)I MG}Qk9fODYupRT\p3eyV]\.spV:\p*%9\jue;MW: :Fr4C@u9C!&Q 8| 8Hh$0;| |xqIwXnQ.SPxqH>rP/.]a?>:zԝQ#!GAyuB#"'SQv`E/Q/R/RuF:SSS ^Q4Դ  P +:h Wښ-A.N Bt@%ÙӏØ`$0 )"MUX7qɜZTϵ\*sg7,8 ѺW .%I^TW .%YZUW .e Cn:\p֤4$2>x&Pcc!(41!9 t3rt%aV Ն+1aX uf1$;;Ŏvbco,ZN.;x&ői-.ͺn,ZKO1v`ŋO1i0Xi-<,ZQi-<,Xc\,Xp\.łp ZKWAt ҋJu+b%6BEЮ %hVTޤt;rv` Z"膑n8n&m n W}Uk9fOVVЬ\p+*J򤺸\p)*/*\p*\p W .֣tYGe M1 J hZ X%a@hbj 1h=cBjĬ=cts. Yqev\@!6ZcӬ,ˈ&4ahā&΋S4ahCB󖧜;. 4F< ,J44M-O8hF-O9mO9jL544MEP.hh-QjFj 544NAj4NjDY: EBahDYhHha;sP);4ő]\3)3>{Uk9U|nYq+FV]\.sp%yR]\.spV]\.spVVD\p*%9\&;!ز2Zw`+b˝qXi\;@wbwaq+$ @.;` Հ.4KP$.;x$.;x&Ȱqqxae M e @Yxc#@0 C1 !hp` B"R@ &B'L@[GcgNØb$i3hNUMɻ^W}ﵜ\#t++FV]\.sp%yR]\.sp\.sp\p! Cn֡QJeT:ks G@f`:C@w0!45`J㸕㸴;z4ŠՂPwW.wwŠ R 1`0hh!:  BCB"@`!hZ@%ÙӏØ`$ "",DYZw@꾊 V|n:ϞY˱~7BW .%I^TW .eIZUW .*s%9\+AզQJj{-Q/[lt{6]h=P4]ZL)gZ X:z 1܄VƘA+=4%Asv;Zݎsv4J4NwZxC9.]֞>nv u=<}#݀йs>v@hh]sv;'CD^K˫/HvG7c4/%\$.c p`:#@h!*&VP;8K<~Μ~`dSJ6nݎUVfL+{{ ~7B ɀ ʒ&+*J򡀀VLԣhƢ*PI86L+/~Ͼo6fL/ ܲ6,j(rWUݝ'U춽f-16yS:(yuRitWL1<+ Xl:Rcݐ, Hi:<7cR9lYw`uyX3f~cy .]~wcRa%ˢ~9Ǚ73"^]g~y̋yu?R9Ǚ9ȼYp#ψ23"ˬKyffV^]gCs fE伞a\%9ȼ+c2/%Csr` c2. rat` n\,0nJaBD2CShWBnӯ"wȯ-w+.'bY(B>sw'dM%k-~+ً^ L=UJ1=>(e?#+͗'ejsW]Lt@H H`b.D]E̥` 鮮ErAC87Zb&fЀF#}Zvg/#)ٕӯNR4Q[z{&ϋs{(uk25Oܮt*~v#YAOcv1Љ eYZUS( YBQ$ = ']Y$ҬU17Ʊ)UnrsΖ;u,TQ8v}²? UN׃ƜfDrWnw9Mul5[.Ӄ^sMQi%պQ΃Д<ڙˢS4 ((4wFsrɖQyYeCr0Ҁ1 &YB 0&Z@q  ZK\W`! XBH% R`bY(L c-3*Vi& ?=/Z&KBmSO2hM\. 8>hV4wrq@qX|OG4wp*hV4wqX|8>h&vqX|8=,wu]Cc`X- @ +8~;ҘcZv|?Kwl<^,aDv۠LM0gw8?`Sy_66M,Y?rtQ=/>潩݋fٰ=1o^';N}9ybZfzeke,u%#"NMԛdv-j0z*nOcZ"ɺo?~4ܟ<r~BNX/rr~GIHlNX/rr~GIHlNX/rr~GI}HlNX-r_r~GI}HlN8?KGIH֞*9*Ipmw3MN'yq,_Ec YDXUVVdv YVS*)D`*`%R,Lgr@'g=*/JDjewyd}Ufc+B Wg& );$}c)i C8u!ebʋEQΜ@Fx3;d.Hh3G;:.\hr.\"Rh3G;:02sG99܎00,+9W|d|jyac0,3SΜ##VO9r|d|JNzy##zy#Ǖ`XW=/a$xSNR{gre5AG3hrNM7eJ>gٟ쏴ҜJLt" U]4+a yIIF8mdH_^Toĵqs ^Ph)s=<nP g9!`,3Μ`Y*g2xT)烌a`)T)X, YHģJ9,^!xqGGQYi۟:8[ڗdذ&+tDfܞxU{V,WU|Nق*m ]GiyӪNYY.g?ahgT5UbMuMuE41hgEXtů qs}XGb?/Q؏slGhcg?`}Gb?/ .)󍣞kOv#g?`,h烍kOv#o-k?6kۉjiѬ]Wl8Q+?Ԏ>佣[C!%/bYJ/ ʳ*q~;~;iiue2ðXR+`&U+`JPV `!V `ީb,_E;9U.cU9&y`!X{vV*z7Ϯ7,^ͧnc\pӶGO%.i"kN$=kxs'b&gZgD$0窆r鮖3La,Y`ugIV}C: '9>@lY>@lwgW`Zŕzg8m%>@YzFزV}^`MdaSb ba b@%1@H@$BSL3;O08Mi2꿳}aQEى9׏]8x11RLO4_GВhR]7HG5UVֲtJZ麠/r]7r˩r˩r˩r˩r˩r˩r˩r˩r˩r˩r˩r˩r˩r˩r˩tVUNrv"ޚohjkM tZ%[V}Ug/(ݳ)žeHշ[3;Yhq*c-|T"#i["1iua~ijSF^JQxu%ty_ꇰ;xSi~ *3.}s5ڽ 08 mIPwMSG檺7^"Zu.\Q{R{R˩r˩r˩r˩r˩r˩tn׍xКfSUqww]K]K]K]K]K]K]K][rS-*V]> o!km*ܺ껳aAtN8ITafR6o%ٱcbNч3G/mZ2m BUna,rUY+`eiVJa,eUV `*+`%`9b'-C1*?JvsҪ\0ft jXI~('\-ݿ(LJ1g8#8kgdϰ{秓w݉MMc9ahᲾQn{O310檗=v,,z( p57ߓ q LC@:r0:n;li ƛ9juv;7:黫ݜa`軫ݜa`&^QrvsŇňy/(wWc9M伢wg9pHwWav+)E.z00yE˘X^Qr,y@VAd0o% ^SyU%dC&^PZUVCJʣgg=YvgeM޹7#&܌Rk@ \ܺH"".\"".\"".\"".\"".\"".\")T,@y1{:&:G6GwuihsSܓMSNY_Y5 HBy;.>*4lbEN%-5LDn"m4~ghyU+ ܸ,+r˘a[n\pXVa. , DX&28nT,+rˀ·. ܸ,+rˀ·. \-t] 2nZS~'g;?Y{ǟҜ&n ?3?oxi-)f~?oxf Et7HE7I .,uIiNnMpaWoT|x7iIM%sL< LNƙ&TZKJbukf_c[S#^_lGRר6IWzU)gj 4ekаt>)[$CW%{=qQh}qs5^ݿ r;FF"mucMzN*y5%/$~OGC=MZ2u0.dPd<ǫXEOZ *q~_[>a?.֕4KEUb\?JXso|^z|*Qy]"*8Yj'>[ e7zT5l\^QI}"'oOG:O*mn@R슛8ӗęae"ۤch}GrVQ0ElsJbU2\bLLM[c "H "H "H "H槹:9@}!ټvz %SLCOy0KiyKjy$@!"H " "U5Yw &fH "H "H 5}gG5}`Ji X,u`fO}YYs`ՂRTIs`ՂVUZU6 X,J9X`6 X,@N\s⤹ϵ1fovSҢ0f#0f#1}v(o[8TJӸ"l;8'+୲zut9mL^,m 6W.  IOuNnx6Jcn֊3n_}b&x;Z+K{pM\4z֙{EqV“ Sq+ ( bHv` b ,`H% ,` [*r`(Q ,;A|P1XvL1Xv P_)+ @0Lq-o'*;um|=OC袨MK,i,Ե[eRˊ4uE~2ʏgZkS^5|U&:&|ws-Je2k سX_)v+|R}*OU*8,KJ+f__p>')1\fZ&4}>8ӥ=sb*ĦmK/;\6Y5gڶ\,.fpNlGNM1-|S\rǮӎK  _3|M7u~8Qަ*׶r0h~"ݒzK[U휟z=CXc)f}<+S/1ZԫU++7)Ag;nZ{M[oSU㧚8J٥Y *վtwxO&oK%Lߍ_sCh'޹5d!׋fO21(<4 ? Os6y3]|W8ҥåiZ1^~}CT#|en\(NjKl{䏕+Y97|ٺ~d> p6Z릝bܳ UQҀ  5=Or6_<;eCh =;kSJ^[^P$@ `H "cR"XU̦n7pfn " " " " " j*-NUjw `݂ř?C*J򤸰X`)*򤸰X`)*ҬX`+(ZUq`݂@,;Xз.sg9Uk9fOvSҪ؝0f8\c0f8\ =®Z?ojQ&S0W4M^Qyޫp"VyLi1^ :pq4ƣ|*_|mnݪ|s,OOC#ރBVe-:D\UC1apNہVr tVUP`A!JЮ~Q64+)+OKۢ,)k >b7ٰ让{DL䢩" zßiU{*~w(᧝&w",EuM3{uDb*k|q\%҇K0Z7 p#ȾGp7 <$zI7 8.gy!亽!uzI7 8.gy"!(s;p d$;x.gxp)y1ۓg:1ߖ ɵWb%6s,0s]'[ke?V TV$ӳNvT~xz~g8qꦸ_KsbEtg;κcX3bx[' ~'c>&0¦*|8gfF׫Ўyٻ]-kHRXQ4S6TI=9UQ0)o26VC/!S(]۝V<z@SBbܚ%Ҳt#9}:NJIxEq+ЫR"Yaz>FĹf,[+q̖}/QW1V6&ArͶ+gkTU1T+Y+Z|`WOVUݨ2bmtJx\b@$p_ Db*=cJv:tfSiy'[NRjtDoވ8H9T)+询>'^j|ٛ/RQB7W=oɭ7k[|eוyE>ƯcĽ3LuL_DW @0vJb`$毹aӲy9;'ACtrb~&_O=mΥ\H^",*wH毹}槹}i "c3~TIq`݂RTIq`݂RUIq`݂DcX,w`ѰﵜU=b&'e=*/_e=*\p Hs#.uNIJ.;+bf夗_X2η=?fm)lʢݹ(ѭ ]58"'F7-ó[O?k}L#H«㬫~_Ģ+?qôsͭMc9;] Mú{Ra>j?MhUHVKva &@<`@X/X[/4j_ >b.zM0xo&.1}U;8NK9@8JѝYjRvW>)UXBY*ԔլRmٻlۿxj}(J8Ot7/Q \\W\oGqɶW4vluc ջD}c JJ>FQ4zw"N-YЌzx}Ě*td)Ut%U*S4&}d~!8-bv1PE'fY.[# ~jqpq#t}f1il¦2_!bn5JJU)lI޿cuk{ET\O*l۴ajjzΣVMWe/Si~3)vԃZgkiؑ:IBnrMEE(I[퍗i/39LеHUjFϡ,N!´ܛe}{8<41t0\fUr)JKX9ɹ6wwpeTDTU11n޺o&P$}*Zx NQO>r|0SfaaGO gMݫi{k|LN^X$Oc{:% ʈy=NUUQQ;z}[q4`%YŠR!'l҃YoGKp43f'}{׹($g+ %ZP`|[6?2q[3g~e~WaET%p&74}bpC@@(H9Njn];'dzapӬzu=1(:oRb*v(L9:g+zgOZ"SujTn-730 &,9RW%łv IRW%łv IVVełv e,;XBPc|.>]qr_짥U;)U    ˯'6ϘϒM?gr 늩1)UimJjr'FYY_mV%o./1xnk,j-_R/},ltfDVOSY:gKdD0/Γ22P7M)'ff>)rQS[{נ'ci⨽9lqjÈ|^iDbS%oaDiݧ{FiШb(r*E{]f_ P++;<0WM.yp^qE>lo)ti}yNɇVZmsY4S0[ݍX)yi9_rmk߈Q0( pfLs**8/cvjppX+]4'SE[`l4[Tem)vrRwMn8W1ɯeF(Q*jPj4$CE7]~(pnMsi>4gFdҭ59jf-dfFHM8B)ŤpZ5h/**RI%'6Ѩ.iµtUU%gB0}YUy#>v}XJ$}Gß(u=v= ST6І!wJ@$@ PJj NN簂p?tLCOßlry9^H^)"l*誫@` ` ` `槹}槹}OeM=2V X,Yr*K*K*˛,u`͂V Ӛ˵.u_˵ ~V짥S\@\@\@\@\@pIJ.;1ԵqK0,mMUUzzM5Yv bp6՞5ëJSELVW[{6nѧ*WJ|ΏCG8op[gjxQޞ1(fbwi_j/g S?G?׃#9C|Ra],f `faAT7v3Vv.W83ww.]~7g]g G8۞߬w8񝳌.g# tq?mr<U4m >'UE7IBg(ў"jNRI]Êpk}hvQ햺x3n_.%? zףc MU}š5e6Բm{4WS>>ѿO+RmE)|-zTZUUR>Ub|f֕ܕ2ՙO6'G4w#觷&[l|f-4z| xa-8 gܶ/x~ړ ŧ-Sj9rսg%!H5?yOH/*~Ry|9WLzp;8o!w% @J $'G5=aaa !!(uMjLCOy0Klry9^@  /1D`r3fS7&nbts?r&{(e;X%yg.,;X ʒ.,;X J.,;X&Uq`݂,;XԒkV\vYŋ~VH``````퍵jZ%{Q >"*w>cb\OZrz>>&3Ê{GRÏ:n3s[lq{]e-'D4xeOUji*gjŽDrvѻURߴ4mtǏ=|EQ=^;{==Ïs=,nCRaU0bh5%#@044oX`.Dhޱz\t!>oY.]=j: |ްsol 9c.uhO[:Ql(}[-|f+ɸAWI*rl׾VIVψKa''oJ&)- N#KƛQ)ͻ7wkd~a/Gi'$z쬹ϡ-Ϭl:/>8(;9pi*vmjӹ쌟J+YS.5U+vXI.Vs ƈM]Z/c&m > f=r~AFQSR˕oNB>_iӅ:mNh~ P=>,(upf/UyݕM눊*xs0>,_y#>e?gȞW p;8n!w`  BAMG5=acȇ@@IOy) =,69g+{gsxMD]x UQ\@Zw}B4PC9`݂Ĩ\X,w`%yR\X,w`%yR\X,w`**X`  ,՞˵,KYsg.Z)U8cDl:X 9X`$@cDl:X /f 7ao&[a7ES/M\(*t}+cڋgfƷU<ݎΙu86&]u;Iͥ%fxk_PYj.`\)O_%٧#f~O |9<ݩj6sqYkT).vsq 9Pun;ԹwZSwu5@QspZN^\Ov7GX=*ʥH˖3J''=8^qTGIa|=k9Z/o?Y:`aGjȼٛUJoWq8QT~OR#Ky:R9ԗܪI"mMjK0>9=A~A3ڂb:?rkGKZN5{ѩ*MzϪE0ue|ؚ^'%aQ>Y_Ԏ^j}54S5M|tFFw\7m‹^/~]~kr_PF*\Ӛ.B>jaaOn|H/bvR­fuvUo|<й aM/$y"|w̳O+Q'vpb @@bH$0C$0  0@ 0H @@(H9N*{&;'dzcȋ@ZPJa=49wS3U-NJl` "lLٜMj)n}0 &XbU~TIq`݂RTIq`݂RUYq`݂VPC8X`\lKUsk9f/bvSҪSҫOB|}=Ohe%f|+́|*5_=n|~_Y W#:11v\ZqS7{;7 =Շ\F{uLLlm|)Q=ըOR<-4U}8ss?Ü stOoD1߳;z³ YI!z .CWwQ`;zE~@_@ˀ z%k_yvnG R_`vjȚi1]TΌV:s{(#:iWuVѫ6\"8}o|lȭ5_15sFΪ-OKZƌ4z9} n|ɤ %_JK>aiGmnRsLT\b< lnQVNl,)Sݪyo% \ij1N 4_]%8ҘV>%w=n# T٣*cmzk{q<\j+Zr[|wK{P>TpXxxq3}g޲3yᦨe*w6rj8f G5"˜߻CO\C9O"Rrݭ-5ȧ*jڍԦfM)鼲-Ztojq_ZBzABjkMsk&zظSU11 BP soI%_KLN9IEj<t;V}!vZ5ݥ?j+_\^ u6Jx%[ߡḙiJ)niIe82>(NnSΔntݮmy[K n 8Ns;uuu By*VE}Gf1XyՌ$clꦶQpZtܤZ#|[~4۴O))hַ{wl`jQM;,e$} `[$Zfzw P/@w yȞO|OL5ag b@ bP` 0BC$0 j{ Nsçc,u9&JZmS1y<8+k-ܳ!ߌ;.%4Sށ%0v>ŢYYRPu^ X8ql=/3m>p$` ` ` ` ` niM;Q`݂Ī+ʒc+ʒc+Jc2 ,!(q`݂@ױϵؚ>q'1;)UlNzUq`P e G`&Pv e G`&Pv e PI2ęC(jwGyC(CQ睥JϏ\I)+3ti.T|"azjWaƧ m1C/EQ4>b66ōN>c{jT{RVg>MA|W}gwO{~ª{oG l9Mf]D\;u\9<ݩj>oYa1KjˮoXg9 uZ]7|޳Zu˻7?`gјǬW 0ηf.m'A鿩~ҭ(o:ĞSֳĘ.j7|QVdVZt&өRor[V<ƪXZn6Z룷5In>\~UrƝl1=yt6 C.{}Q>Bi#܏숿054ܪ#mNSI#5ķZ*aj6|>7=4x_;U+Vy3EvkWeVTa+鿱+RRe8qCZnk;6\*"Ni} 0e¢/y?V$Q&MPϵD^2TpՓRuF}Tm,nrt9',z;gAOj pp| KKM#nf8G*pէ*rk}]ό85F+ElW{aNi7ЛܽvV*N4&բIٵXX#$L6)5Sw-.mjmLUZD;'њג#|9߄.봧&...щ5724E)|Jyh.r=@qxvg뼗y]]0=iM;]`PJrYˋP+*JҤX(e*ˋP"ULłyC(łyC(иsg9IGNrd&'e=*OJRLRLRLRLRLRLQ;<G2d;T'-fC)7".֗j8wR ~EU A8{YA+jy/)?TYĶ;)>/)lg*秝鍃hC>zpv<3Vc^Ԫ>wCv>c/)U$*g4Q^G3].m {511c mTs{7>;WۮwOn;^1<bM3y[j=V3 S摏,<{/U&{ vSO2񣲚c` *pڟ90|+L]tbǎeײQ71 dUͿu~5}u1lKØVf'(vVCMuc/QU dy )q1챿Le~d;65[֞٩hD)WrQk=;rojauVo$O#VVQ"쾆>XLW_48vؘUaͪ= wS jὦy{ :3fnkC7 *9LdŪzj[у=o`~rE{:ij)+Hϑ>v]dsVWnΣV]qdfRFEMI;o~^羱ۏ!U߲wƏ{Pq8Fy =J*wYZkkߡtt`{ ?#[GdٖfӵG|AOp_|/y9k_ΗѸh|KR5cI9]ۘV=vР/x0߫ezt)k3m4+knxmMNPi:6/riZٵuY#f¦ljf{FQJ:[.zzwrmjFâ0,33?yby?=0gA{BPb @` "b&-q&[h1G2N>]Sidz:4 6鿊%Y!Z'Xv)vы:0܆21I/Ylw<n{EkUY/\d}{:l3iFu13hvwaLwtGs]OGF[;U-]O'6Q*jl=IsiO5~2a{QU7=qUKtm z/Zaֺ{O}@/-FsVoJM7AKo,U٠l2DN?^]Fz;oB+'khPm_A|;I~T~8iޟ{)V+#>mSB]C#j觯Dש\Vk_ ~P~0 x}hgW a/a4~jXi>egOG;g>رmahzPqȾ(:폱*8}{Ynxkfu3ވxIRaTVXFR,I*gu>kUbtG9\?O%3a_bNLwo/;%&X}6^ClZV*$yl텃|_>c:pZŞ3;)<)Cjy?ܨ0# -V| =UOwq v\UV{%1(ʏ-ot'i3g(jDdIRn^?Жf@ޞ )Dz*/*i{o+mgnqUDL6e8;oMrƁ \W=so`t*iD4D6xqu8GFϰ-L=jb<-¦Mt[2Ծf~*|u)BiqxJPWؼI^:%w9xB.[ ~0Tk<.> [uܝhg)|ЫJ?z_5" YS5 x'hGGK{ F'Ʈ j 01J>k2w>Fﳕe㠥\}d5/{U飦4կ215Z; 9?(?(~]Rs\aSe'a=,Fe<$zUg'ڙGL"c޴g%+w)q羪{/YUޓ=<8wmW_ "x/jz~WlʮѯJSx5/]UNf;sLEYlس}gyi<5]cV'n)4oM '7=fwB/ԙ"ھN_uJ?@D.%uwqF>NJJYzzꏣM]Ɖؕա(/^)Wv-}ٹv~}<U׹Cٵu8Q#~JʥDĔYOFHn]7b{q4K¸7ca(} ^AުѷO9U)pNQ^aiLU/sVkr_ꇔF]w" >DŽc=ẽ-_{M\-ETb{>8yօr]?"q2Na%Oa柑jtsjFh \Isj]đ^{Gm a$<'7:b|Wxef!eRS)FT~)=h>m:WƢOQO)ᾧeE[,x5=-gJ)i?(zm V4ѿ~3أ㫉>&p8[=G>7Zh2^UYYP*ZU%)5t F"ra'(+YKDLoD0[hyʤ;^W^v©N*E}qMYb6u`jU\+U8Ɣg)5tJ;ֺ/4(kdSX3qROy\'GDJx"3q N*i*l~)Gcׯ⪪{|-iHs<̧RU*dQo3Qi.ӋXDŁ i4\ⷼDW~SI U)=(Mhk; JeO<*q%Jɥ=PУNn3R8S)MR(<,ynwM{G"; Nx|_Er:xNN⒴-y4['M(!:suNMqo[^>4V"~O<}ŧhbn-1Z\lGId\GύWR<U>]G }s^|ZR~Qe}r kaaOڐ˶ƌjݖ~mNz`5|bT.b?s~SӍ*ow'K慁S!/\L6M&}ΚjfF꧿,#~N+)]qzc2d뎊g맄~nUݙ]<3Sǜ7MquEL'1J++}'ํصf#Ckj܏ȩq}ozZ/+gw);+W{О29ϛسi_2ʾū(ycyXVW:F6j2'umd|f$z!1V/iTnĉ#5)&ktC~нo+w #N1}|V==&nN]gR׉VŷF{;^ kEq>(R6+LM im\,$2v4nuʕ=?F҆>zi1T3/e-S={痹FӇ\r~o]Z>'<#-]H(%lteӏfRT7&_4÷'B߃ޘ-G;وD;Y]E^*ᔣo,#+tRd<'n{KЫ_}W)%+/Am}C((I5ۿyщVJ"aSE9t{`LDoY][rrxT eNk?RM_[ƥUů+-^u͋v!/WUyWRo֎fŷFg 4ucaDux -A;sos4S|WԬ޽Y8jNN>HQ4:6|jkæo3bb]%*QU9ah&/0NӕJ5"+wǚXZK3Jq(XZRbgd`\!(!  d*h|Wp,~INE&}eIVw/*չ<;$j7ӓvw>֊>?UMOG:RPކʨXXJ )m+YSjuH_3Ěd^xvya)Utʔ$k?NVZ)E[өэF\_xR4Hބ.splxul~}Y=8ΈKm󚻞{;o1CwN+n2%7 -%Iupg*򬺸\p)(ZPsCn C)e_DO_=*PKyB+rrR\ ܺ(a[E2XV·M<^R*}ccɷ566٦شntMZ&ر+9?p~oYR.!/|E*(O/'DOa3:Ĭ5O,+;Ksӳ#^U,L9E(}Uk43h^Zu1%RR3N!O#ǵv= &ڡ q\iQVԚMkRUQN#MdMQ-O,vo rfZqWUa|ҧUIJ1Rw8xشfѭ7ztx'DY6exd\,MMԊTlά=>Wa 5%EVAb|(YŹԥ+9f9ݓh8biSmnJVw# aƵ.c=,jMqZ"K-6#hNTm8I+zKK|fggFίDey.)iE,q[8nAj<76j]4t?O2UY6,>ka)Vth;7m3A?ړIU|4agɪc+UyNNVܛvri1<пTYWgg *BU;<=zL}]i9.QaׇTS4f=k^޼5̠H^Ч)ߕr8CçY"o$^":nc7J9\R֖ʧ_zd&g(6pr#L9IU2J-;>P^5hU7we8-b~kJ'3c4mJ $䴚ny'^ՄA_+{n}E۶jj2UՈx-eBt˧ BxiN.2[ԓM| +ҭ ˣD` ]uFcˉ޵8zkzu3cm”WG:tms?q)FryfJzIl" Q"a JWjRVwm_Kzikywj=|*r׋=7Szhh(Wv(< WR{YإR":ܚ}U -\F/ Zqݦw+P:Psrttal8sbַ-/:𺦸LS-Þ^bb$*}lL9ISZ;,v/*j2䫖ݦ14r&ݣΧ[7hex2h )|LYxh} 1{q=q":QDSmbev:%}v-=j'(U&w':U熯jN$kjcn#%,5IjR|ݽT[#a:8Fy}KE{d֚ƦjӒ3^cN}ХUeakNhqWQW^P1Q9BQN1YSZOm_Ɋ~Qוi5 *Yoi;ݨiB %|k3{|;;|Sm*3%NNsZ: i٫jm6hT]&KbbMnUͬɉ44T9ש8BXJMOK}K )U|U o|4 .jcpPЍjqtq:I^ NW\}=[J?+8YR޻JqWo#lکb=tii9Zd<Ȟ6LNE14M_3ԧW tIENKGġ[KVZ43RyA5:M&5e3o(Vvݻ:ī晘kE3ݿV:b4iub9f&W}=#lE iTܦtg,=E*qQ)fZM7w{o| 1b'klΪ-jQTޘM.4@~K3f|!-_(dGeV c>==_B& cC ,J?38F$kƾw5oCҶ}FJ4Y: Y˭)v/hs!gKծ]>%UU3Ԣ-A1 R7`6?=g#Ӳy{90Ej@zպnRKAJmsWsx_l3y :p p g7  \c9 p` ` ` {(Bi 9RZJsT\p3eyV].qp-(wpU ! Q`()Abʾ{=|szV2SZ躷.(e$.ˣqDH˫r^չw6 ڐφOz0JK_jQ:e6^mWu+Ӵ לV9z3?sL"\/ݥ:0o ?UE'Zc!.FQK=~#cZbtO8K)eŇ5EӤ"J1R2*% H! @JBP01!@ɭӕD%ݫ'}X)9TI4d} $!Mعۛ]Vk7BwcJ"r)%(ӊu6'diW9:6y\k [3wJTnw uqܢWt)]ˇ֥F)FifRqk;wM6/f4d5~:7ϼ"ض 8! QK$֊׷6}# O+>ɞӋMc4Ľ$Sڹox'- sc_Hy-דf\\_*e Z%}b(;dۗly[Mn,Iw<Όr5&߬kqܮ^ʄ`ISM=j BIIYY YnIv:h[MduZ+UEsn' }Z9MҔ__>dג{{Qiߟy,xT|v'SH:IJP=};ʥI}/Nl= ?5y}J{P;#=d PFSB\?KVʍ3g}F^Zis^=dݻ (}}gWbEShD@Uj_=;;Siׅ jb`mEq.96ݯk5^'챦Z6a҄} #*(a8k=acpK^ԤM8٫seg!VjwZ_uJVN1qmjçvjDnToog^@>DCPR|ڳe{x>xʼntZu߿ƬW$p|8sIEi{^,)0/E\SZ4Rlo**l,%Z4ciq;4EZ|Fs*sūI:msSm>.xj!"͡Qpr5^ O=<"8,+RrsPRUPLf3R2KFPI;h{v>aLUZ5(ЄE$辞vJPZyNЍ7xKu}ݝ5uKћ]Z=3U5W\վ#53}GP:#ETZJֿo*3jF7psK9U⸟Bⰰ֥LʸUz>ZVG''Ϋ Aom.t~+qF&iJZO$Sj]vi[^۰4v{_R)lsi쓗oEWi-%Ϗj3UU;)+BJgܣekg?3~fp&oj]TU6NX9Swihr2 uNr}1qUaUVRyԔ^[܈O0LB{Qwe &ҧZn:ЩTw%RKwRMᕷffrԒ'58yaC%YuZD(Zմ!(RyMH6FX!wӵ#ٚ)|z}zSepte`gygI]7et572gԝ06>W/5ss 9Wprp` 0-Oe Ge5 ?I*KIR].qpʒTwpRT L;\p+*0.qpB,sZ |zV$ҥ,uaXXZչw6;&ZԹw ᝳL@˩rYgL哕ir\2K]|Ln!|lSt3O&xYw|2c6"Vl'/l_0&0,}E?>B#叨=~G#>VO ^yODo y=Y?@yVaiV@w!YZU@" fFZﶋZC. w lY%bb*T ~rB[<*q6bĉ}l MK BJwr888J-;=N|ɥR&%(g箏vyIJ8,,#iMK'3^m E[|v٫ê}͋\U, *Tsomtݟ`x *0Wf}Ghc%m.sM7iZn ͦ`Ӻ5C}֕RF%UmbɔNKMfw.S= 44D&fcVYIsQhz-O|}T#i&prUU w8\BIs÷xj}=~4:c't0͑SQ^1oK6{銩g̲(k(ԓi(pҕmwgx͕|YYEβ̈E17J9fDBPȬ*%{Y;kYv? ZS:eioR|WB2QدSm10K?!1 z;Y7yh+V ȍ5x(RYfM=meE $RQIJT~T:kJvߓF꩞BP^NcVt6O.d_Wu=*|KwtJKޟr86Ԝwm;K^˵ݾumLۍmNv%EYIuF/]m&ra֭V-t26mo"}|=FNJVT+΍,5 Eeӹ-&(u5h]Ti})~]}9{CJRnL5WXZnVRrmۆEĭ^qeY()E%ɶ뚵޶}y/(bݭ}{E+bz&4姒y=8~Vmb%ZNtuZu|yEƳY`U_TprvMJZC]_WI^B*VST{8fzitC<=`阴Li[s1wJ]DTW=v[L- 7|M_IcѴ5T?=}O`}eE6اjjяd9*VT4Vgk+%0ؾduj:kk%at23js 鞾U0g KB,-l\Þ&D+7w31fMMN槼2,.V4Ipr,;\㸲@.qqXuqnnnn wpt3p p pp 0'b{-Ge Ge 0CZʒs Ii*K3`3e0s !{+gw f U X3`*&ŀ4`tI쬇ܑK渓JbvsҢ>B\;U.FO|;8gTcT#dNfH̕(ΗoyԪӆ#/D՚pi˓}dR%\&NipK >x*Q3"qO>WB\Le?TL6͇=6$u86oiy|=ddz SO߉>B~#Uz⏮G򴯣 ']=]%.,Ś וeed"JҀ{[=k.dV/TGlVUL/rvFlK]fgEge֋ٛ.mxJ8Kk۝#ÿe |Mx-FEU=K]0ia?p&%%S)W;#M($GդM4{=ieD3|Ra΂˭davbj=v׽W6ڴZE(fM֌}˳ѣӛm9{5SS DG2,Y^1NSfhK*+C==K{q:nG[1y^\mv~#YG O <=us3k"ھ2*BZ1d b{YEMIE;_G->}O;vNK[>oEAsj$ö}٬lsAsi;=zy{;VN32LJ9W +8Q-b&'y*b|hll^vMqt^/D`Q[xsվU^򫍣B uk.Q忱mE;2ƽL5s &ι++UV|L"N޸t:Sd0.$ĴRiNfWMAҿkS}>S{Jr֊p$U:2v'|N)ˁڢ"鋤d9-֋1ty$gކ!(FME |.M "\Ɔ.;];BXnHn" 8W .w .\ p[-Ge Ge .%)+ʲ0f8\ YYy1g0.EE  K"Xp+bXAıKϜN{a23U;9Qa,SdSKV}BxvDB]!)'].:1ĬB5&%]ȎS:ePY$RR8gyb=7JiEjem"ғ.e'>vLFe^ELBv+J!_e,?ߩ>WAOoa?MltxbvR&4|czKi'U䁢*_ZB2k薽S9'U䁯<6&5/L<~藕Y|d^;+? Q~?$pN}LխFt%Z:]kj<.էJ>Z6wΚoFZZqqW$Ț%)[։L ^lԮ2哒=sO:C=uPU]d~$VQ} #zPVًT~^|) \B ů~s*jV7aqqܨ´j gߢbiJO#mmTK<ݮkwQv6ʢ|IbfZѥ0&wΰ+ųl Ʀ[]-wJܡԭ(wXݧrEtgqh[xcakMNz_#]熧;O]zJj3=Wͅz}3^sjODx[zQfE| *OsZKԟI~6_uOOc85#,ޞt^v ~e^) |hR?SKrp>jv|JC;"/J&ayG`.*w4Ya6T,(uՒQTcՖx*{,Z{3ⷅT-.P%59"?}я^o~H`c'XCҏ¯_mnFϱSDxBK`~"Ź}Lk`OƵRaؒ%QKx[lGlQ*G |b/"liTmॽ+ǣccu~lY"w.~؝hi j]cTSŲS}|ivdx{@+Zqqx#Ňdx4t|1/a,%<㧙}FG<++-t. M33(4k2hN un aU+׻ae}zͲv=4ЮMbYp}xt0JiwFjj=Qf~;-1:&"10tF8V:q<ԫBe#al]5S0E9]2$R+j3;!Ʋd6L9& ט@=q>$IJksC,DeTCIJeg x,8B,½2hߩ\ ;x~ Ӝ>BH#.DEhՔwF Z tw H'W#>ҩOVjޑتEXhjĉHsr(,DIqL'4%tY˧$ ֌HxDBM0qLfM{ɝ(C^<˄A6;w.r,$\r,$\㸰s 9@]\.sp$t)nbI 5 R*˻.*˻c`+*J0\ .#flY%y0eX(F=vH4,|B;D]6Hpq9p&*,&t5JLtH֜K+0JPSbSh4؊**RikEKtꪕC]$}Fv7Aʆ&TFkc=S3L59je4ıoI*1yek%{;o}&tv2ӌ&zG=qz>^ DxLJN^&׋<~B0]{nӅgy̱R5;#l*"ukS1xmbj.;ɴ5'NIS

VjҜۙpQDFLo ,4pp?^nQKE'حhXsD`8e^3*к}}F+ %MTQUUDn5zhGzhj oS W̶u/i㱸WՌ8%e_Hkt1̥UfY6O=G,'f:]Q-d.ErT;; At8$.nn"H$.ԹtMXᓸHi%xX9t6^)eMn+~}q0'5˫4Y&c-7{c*6/TӻvvYyY)Mnsn]5IGu1EC-9M1yBp bs;DѤJꅢ-ebn]FlrVA4ΊsHL&%@vI  Hdf-d%B2;ɊђK qϦzRZ2<2jxeAHT\ EYũAIgz baUļ&'J3ޏ5Lj{U02TX֢8;3Zjbiǘ"tZ t$q3It =QqDG2^@inV㸖8Ǭ8rőCoК3SL&&$:RGiMMsgNhE qʃ[qMK;\qb .;w"wqrwW M*=).9\?Q2.\*tLsq\J8\;f8D.#\[|BՅa`Gv FМIl+Y)RdUZGUu"axKmp2)jmQ>&4YzE4}̰׺]qEPUwfKQ&q3*4Ӂ]]J0&aK%5\JZMԂ'2f=aĝ֗TYK=,|:&w9gp.M29c4ZuOJ]6L飄0j\"h\sXz-T*r'\:U`5ގ6a4M;Y d90wp99N!"\Q/EqTV[1Xv"9c0 3#0ѝ[ ȚX%IVVƪUL68%D .ˢCH/q[s`Ղ V黋MԹw ĖW,GvڙmD[SRQfjZ\*6 zt)$.XܑWiNt{mzY&/dw>s'ONToK .Q,BfUS5NytN5=}&r0 yjIZ5g/ZgK4"YJtϢ˕^lde\|GnwLw;mI2G})H>R8ӗ&\k'49G"\rJ[ױ_fvQg$2' fbf! j7j]:up9 X9EJ5u}WHVխm9&*KXKU^:QF|$LQ^@8]^cjaw˵z(lΞA(xNkJoXf/+[ͣVd4,B+޾B!اG2sˎ83x ޾Bb89~<^+9wh_ա~3Re .dg_yO2WΜ뿫O޾B6zҕ,O'% [Vu9yVkB|, OS]{=2WyWoMR )K<9IeNK,MO*-}18sgiGYz/\<.*t^.e EvZt./IFx{*bgSUr8+,UN(xᚶM@T/<-F6Zbyܴ[5\6Öy \49u=(T]{cW\k*Qij7>-tQyIV,T0U%dOcivsM5J2)݂H͇av"P0M a`inDظ'Уn$0\{!MYZU [WG!SV+''viO+,Jbj% 0$. HM &Z*D觍7zbaWNZj/0GMM]Dҽ5@ \B/TRzgILԦ闉Voq0D;Inz2XZ0 7.1r 5.ˋ -t].wD\;n+".:\p$@j&AIn]-Q3E;9Q)GǼM'V=_Af,z䆈t85M7@:TVѸ VxflK kģ.Ty\IW]xY*(čWj=YNх_<*ZZ)b7y5O[.=,q.jҴm#rMSG P*L8+hvamq.!m󫧁:e(䘝G>LZ%m5FNC+(^1UH9Џd;Xr%ޏ'"ȳjxzZcޝOén{N$o{΄YSOt3oG+ K֞up/5~+i9&i31k}ip+f_{o'4p9b|IlNJwVHAh !ĬRy~IWO{ <{}']-2꘢} x}*ڙ)N㹯_2jVODN߇5RbQwcar=UnrZu1 ^ӥf|/!OIݦ==i+X}'oEfG >WO;aX=K$5bryh'߅ga#Oy`NIQxX,y#vK/)u2zߏzRcJVf/XV!/2藰uNKjJɻ<дM,E紸^{K 4wMg-"ZSS hM.>}$^;u>/5Ut;q{kgUJʓ),+y8=Og%U3L.9CUޖ{қCS^W<."v͞==:zWu55<\?]>>Vv=-< /9jKFN:x.=p}#zwW맨622&ȮrToS@RQ}OÃ{N%>l`]>fLz<<2boQnk̗(kObt-}',˙y)ƛz`̗J<^nr,ʮJ<>F_ӖivֺW/wcTLIL{;)|TB""J!^щZH2 ,J8,GSzXU0qɠܺDIaX&dG`8?K7.DQaGxMrOO4d; rDa(2 ̆0Vg6;9H*%-5AM4H%,p-ZRCBPX,;f@m !rZK;P\Y6H|v2t dE3NRb-3țdDY]YYE)n"!kNQS~I(ZnZBu$H]Tr\>f+:3b$z9uR!ˠH9u2$&,3HV (6t1x02t.6thZe7@1 )&rt"B`J 1Hi78iˠG8cz/3SzM%-X*;DsBc@Hlt={2QbFyj#-M3*QT*jź- Mi)g5M@jLR`!XLa4ua4Eֻ;GmZ쮵4r#G-4n%7FК$h5MĦ%Bh8\0gM@^Չ"@<`w#K'g=*/J]I!7@4+3adLZ Sr@=Ng..G̪25.%#(Yn<~c]g <^@Y=AT|>D r?x<TY-稌9d]|>E$yg,pyNxHM5JHɳOޫ:M:!ș6ryTgi9΄ܓ$̃9dT_hΜMFcesk2r+x<ٌGyS}ܺcxUbc/WSst9V|`L0}_uGiY>0及O>OTv,l僖>$O:#ܰrǘ8Әt:s|Imrx<sX/11ON|W@W(AOuoiTet'Se2mψmr{{L2[ =}Sa/g Ä==Ss2ܳs'sܞ8>S+}8g>oܞOetga 'N1ϕ9]lRgÄO߹=q|E-ۛψ{m|vqLCA4s`=S;Cq3|4׹=gbAcO׹=gd5rXhmr{ڏ,|8߹=gerGl>oܞ3v6 pmr{fFhl>㕆F|8coܞ)h3qrLpOu򙥎tgn>‘mr{՚> hG{n{|w$b~|'sܞ3h3'SvC@~vOuoi;?;{m|N1?Cٝ(7~v۞_)vc~5EG=qCG!u#Ƕ_)~Tb5#sܞ) R#sܞ:c@G=uOi:`?=OSr?A OӔu | OӔu!>yQ]0{yN9H GH0}_ʎ9JqX{".+vQ'(GvsIc$hC*җI4t#x<؏#GGTq >^:nӄ|"dׅ}(G>:b|ezS2Gh2Wʎ>#10gyQP\mc#UhzTZ+dvTy|>DCJК3>G>]kT#GQvK|SMx+}<>#%h;g~wD. LapY9dRp/ 9g,露Д圳rBD.:g,$9gL善9g,露Д圳rɄB\tYhHrΙ- &rΙ- HY:g,9bcbe"P,3Y Y9dD.Xؙh12R前 bcbeLbdY9dJR1 lDJLLlL"@J@C b "@! $!b @ CJ  b@@c%1 !2c!!!А:CBCEdt:D 9GHBP#t:GH"Gh#t%9GH;G:GhvʢH#RPv%;GhJpYD;Ghh#RP!(B LapY9dRp/ 9g,露Д圳rBD.:g,$9gL善9g,露Д圳rɄB\tYhHrΙ- &rΙ- HY:g,9bcbe"P,3Y Y9dD.Xؙh12R前 bcbeLbdY9dJR1 lDJLLlL"@J@C b "@! $!b @ CJ  b@@c%1 !2c!!!А:CBCEdt:D 9GHBP#t:GH"Gh#t%9GH;G:GhvʢH#RPv%;GhJpYD;Ghh#RP!(B LapY9dRp/ 9g,露Д圳rBD.:g,$9gL善9g,露Д圳rɄB\tYhHrΙ- &rΙ- HY:g,9bcbe"P,3Y Y9dD.Xؙh12R前 bcbeLbdY9dJR1 lDJLLlL"@J@C b "@! $!b @ CJ  b@@c%1 !2c!!!А:CBCEdt:D 9GHBP#t:GH"Gh#t%9GH;G:GhvʢH#RPv%;GhJpYD;Ghh#RP!(B LapY9dRp/ 9g,露Д圳rBD.:g,$9gL善9g,露Д圳rɄB\tYhHrΙ- &rΙ- HY:g,9bcbe"P,3Y Y9dD.Xؙh12R前 bcbeLbdY9dJR1 lDJLLlL"@J@C b "@! $!b @ CJ  b@@c%1 !2c!!!А:CBCEdt:D 9GHBP#t:GH"Gh#t%9GH;G:GhvʢH#RPv%;GhJpYD;Ghh#RP!(B LapY9dRp/ 9g,露Д圳rBD.:g,$9gL善9g,露Д圳rɄB\tYhHrΙ- &rΙ- HY:g,9bcbe"P,3Y Y9dD.Xؙh12R前 bcbeLbdY9dJR1 lDJLLlL"@J@C b "@! $!b @ CJ  b@@c%1 !2c!!!А:CBCEdt:D 9GHBP#t:GH"Gh#t%9GH;G:GhvʢH#RPv%;GhJpYD;Ghh#RP!(B LapY9dRp/ 9g,露Д圳rBD.:g,$9gL善9g,露Д圳rɄB\tYhHrΙ- &rΙ- HY:g,9bcbe"P,3Y Y9dD.Xؙh12R前 bcbeLbdY9dJR1 lDJLLlL"@J@C b "@! $!b @ CJ  b@@c%1 !2c!!!А:CBCEdt:D 9GHBP#t:GH"Gh#t%9GH;G:GhvʢH#RPv%;GhJpYD;Ghh#RP!(B LapY9dRp/ 9g,露Д圳rBD.:g,$9gL善9g,露Д圳rɄB\tYhHrΙ- &rΙ- HY:g,9bcbe"P,3Y Y9dD.Xؙh12R前 bcbeLbdY9dJR1 lDJLLlL"@J@C b "@! $!b @ CJ  b@@c%1 !2c!!!А:CBCEdt:D 9GHBP#t:GH"Gh#t%9GH;G:GhvʢH#RPv%;GhJpYD;Ghh#RP!(B LapY9dRp/ 9g,露Д圳rBD.:g,$9gL善9g,露Д圳rɄB\tYhHrΙ- &rΙ- HY:g,9bcbe"P,3Y Y9dD.Xؙh12R前 bcbeLbdY9dJR1 lDJLLlL"@J@C b "@! $!b @ CJ  b@@c%1 !2c!!!А:CBCEdt:D 9GHBP#t:GH"Gh#t%9GH;G:GhvʢH#RPv%;GhJpYD;Ghh#RP!(B LapY9dRp/ 9g,露Д圳rBD.:g,$9gL善9g,露Д圳rɄB\tYhHrΙ- &rΙ- HY:g,9bcbe"P,3Y Y9dD.Xؙh12R前 bcbeLbdY9dJR1 lDJLLlL"@J@C b "@! $!b @ CJ  b@@c%1 !2c!!!А:CBCEdt:D 9GHBP#t:GH"Gh#t%9GH;G:GhvʢH#RPv%;GhJpYD;Ghh#RP!(B LapY9dRp/ 9g,露Д圳rBD.:g,$9gL善9g,露Д圳rɄB\tYhHrΙ- &rΙ- HY:g,9bcbe"P,3Y Y9dD.Xؙh12R前 bcbeLbdY9dJR1 lDJLLlL"@J@C b "@! $!b @ CJ  b@@c%1 !2c!!!А:CBCEdt:D 9GHBP#t:GH"Gh#t%9GH;G:GhvʢH#RPv%;GhJpYD;Ghh#RP!(B LapY9dRp/ 9g,露Д圳rBD.:g,$9gL善9g,露Д圳rɄB\tYhHrΙ- &rΙ- HY:g,9bcbe"P,3Y Y9dD.Xؙh12R前 bcbeLbdY9dJR1 lDJLLlL"@J@C b "@! $!b @ CJ  b@@c%1 !2c!!!А:CBCEdt:D 9GHBP#t:GH"Gh#t%9GH;G:GhvʢH#RPv%;GhJpYD;Ghh#RP!(B LapY9dRp/ 9g,露Д圳rBD.:g,$9gL善9g,露Д圳rɄB\tYhHrΙ- &rΙ- HY:g,9bcbe"P,3Y Y9dD.Xؙh12R前 bcbeLbdY9dJR1 lDJLLlL"@J@C b "@! $!b @ CJ  b@@c%1 !2c!!!А:CBCEdt:D 9GHBP#t:GH"Gh#t%9GH;G:GhvʢH#RPv%;GhJpYD;Ghh#RP!(B LapY9dRp/ 9g,露Д圳rBD.:g,$9gL善9g,露Д圳rɄB\tYhHrΙ- &rΙ- HY:g,9bcbe"P,3Y Y9dD.Xؙh12R前 bcbeLbdY9dJR1 lDJLLlL"@J@C b "@! $!b @ CJ  b@@c%1 !2c!!!А:CBCEdt:D 9GHBP#t:GH"Gh#t%9GH;G:GhvʢH#RPv%;GhJpYD;Ghh#RP!(B LapY9dRp/ 9g,露Д圳rBD.:g,$9gL善9g,露Д圳rɄB\tYhHrΙ- &rΙ- HY:g,9bcbe"P,3Y Y9dD.Xؙh12R前 bcbeLbdY9dJR1 lDJLLlL"@J@C b "@! $!b @ CJ  b@@c%1 !2c!!!А:CBCEdt:D 9GHBP#t:GH"Gh#t%9GH;G:GhvʢH#RPv%;GhJpYD;Ghh#RP!(B LapY9dRp/ 9g,露Д圳rBD.:g,$9gL善9g,露Д圳rɄB\tYhHrΙ- &rΙ- HY:g,9bcbe"P,3Y Y9dD.Xؙh12R前 bcbeLbdY9dJR1 lDJLLlL"@J@C b "@! $!b @ CJ  b@@c%1 !2c!!!А:CBCEdt:D 9GHBP#t:GH"Gh#t%9GH;G:GhvʢH#RPv%;GhJpYD;Ghh#RP!(B LapY9dRp/ 9g,露Д圳rBD.:g,$9gL善9g,露Д圳rɄB\tYhHrΙ- &rΙ- HY:g,9bcbe"P,3Y Y9dD.Xؙh12R前 bcbeLbdY9dJR1 lDJLLlL"@J@C b "@! $!b @ CJ  b@@c%1 !2c!!!А:CBCEdt:D 9GHBP#t:GH"Gh#t%9GH;G:GhvʢH#RPv%;GhJpYD;Ghh#RP!(B LapY9dRp/ 9g,露Д圳rBD.:g,$9gL善9g,露Д圳rɄB\tYhHrΙ- &rΙ- HY:g,9bcbe"P,3Y Y9dD.Xؙh12R前 bcbeLbdY9dJR1 lDJLLlL"@J@C b "@! $!b @ CJ  b@@c%1 !2c!!!А:CBCEdt:D 9GHBP#t:GH"Gh#t%9GH;G:GhvʢH#RPv%;GhJpYD;Ghh#RP!(B LapY9dRp/ 9g,露Д圳rBD.:g,$9gL善9g,露Д圳rɄB\tYhHrΙ- &rΙ- HY:g,9bcbe"P,3Y Y9dD.Xؙh12R前 bcbeLbdY9dJR1 lDJLLlL"@J@C b "@! $!b @ CJ  b@@c%1 !2c!!!А:CBCEdt:D 9GHBP#t:GH"Gh#t%9GH;G:GhvʢH#RPv%;GhJpYD;Ghh#RP!(B LapY9dRp/ 9g,露Д圳rBD.:g,$9gL善9g,露Д圳rɄB\tYhHrΙ- &rΙ- HY:g,9bcbe"P,3Y Y9dD.Xؙh12R前 bcbeLbdY9dJR1 lDJLLlL"@J@C b "@! $!b @ CJ  b@@c%1 !2c!!!А:CBCEdt:D 9GHBP#t:GH"Gh#t%9GH;G:GhvʢH#RPv%;GhJpYD;Ghh#RP!(B LapY9dRp/ 9g,露Д圳rBD.:g,$9gL善9g,露Д圳rɄB\tYhHrΙ- &rΙ- HY:g,9bcbe"P,3Y Y9dD.Xؙh12R前 bcbeLbdY9dJR1 lDJLLlL"@J@C b "@! $!b @ CJ  b@@c%1 !2c!!!А:CBCEdt:D 9GHBP#t:GH"Gh#t%9GH;G:GhvʢH#RPv%;GhJpYD;Ghh#RP!(B endstream endobj 2765 0 obj <> endobj 2766 0 obj <> endobj 2767 0 obj <> endobj 2768 0 obj <> endobj 2769 0 obj <> endobj 2770 0 obj <> endobj 2771 0 obj <> endobj 2772 0 obj <> endobj 2773 0 obj <> endobj 2774 0 obj <> endobj 2775 0 obj <> endobj 2776 0 obj <> endobj 2777 0 obj <> endobj 2778 0 obj <> endobj 2779 0 obj <> endobj 2780 0 obj <> endobj 2781 0 obj <> endobj 2782 0 obj <> endobj 2783 0 obj <> endobj 2784 0 obj <> endobj 2785 0 obj <> endobj 2786 0 obj <> endobj 2787 0 obj <> endobj 2788 0 obj <> endobj 2789 0 obj <> endobj 2790 0 obj <> endobj 2791 0 obj <> endobj 2792 0 obj <> endobj 2793 0 obj <> endobj 2794 0 obj <> endobj 2795 0 obj <> endobj 2796 0 obj <> endobj 2797 0 obj <> endobj 2798 0 obj <> endobj 2799 0 obj <> endobj 2800 0 obj <> endobj 2801 0 obj <> endobj 2802 0 obj <> endobj 2803 0 obj <> endobj 2804 0 obj <> endobj 2805 0 obj <> endobj 2806 0 obj <> endobj 2807 0 obj <> endobj 2808 0 obj <> endobj 2809 0 obj <> endobj 2810 0 obj <> endobj 2811 0 obj <> endobj 2812 0 obj <> endobj 2813 0 obj <> endobj 2814 0 obj <> endobj 2815 0 obj <> endobj 2816 0 obj <> endobj 2817 0 obj <> endobj 2818 0 obj <> endobj 2819 0 obj <> endobj 2820 0 obj <> endobj 2821 0 obj <> endobj 2822 0 obj <> endobj 2823 0 obj <> endobj 2824 0 obj <> endobj 2825 0 obj <> endobj 2826 0 obj <> endobj 2827 0 obj <> endobj 2828 0 obj <> endobj 2829 0 obj <> endobj 2830 0 obj <> endobj 2831 0 obj <> endobj 2832 0 obj <> endobj 2833 0 obj <> endobj 2834 0 obj <> endobj 2835 0 obj <> endobj 2836 0 obj <> endobj 2837 0 obj <> endobj 2838 0 obj <> endobj 2839 0 obj <> endobj 2840 0 obj <> endobj 2841 0 obj <> endobj 2842 0 obj <> endobj 2843 0 obj <> endobj 2844 0 obj <> endobj 2845 0 obj <> endobj 2846 0 obj <> endobj 2847 0 obj <> endobj 2848 0 obj <> endobj 2849 0 obj <> endobj 2850 0 obj <> endobj 2851 0 obj <> endobj 2852 0 obj <> endobj 2853 0 obj <> endobj 2854 0 obj <> endobj 2855 0 obj <> endobj 2856 0 obj <> endobj 2857 0 obj <> endobj 2858 0 obj <> endobj 2859 0 obj <> endobj 2860 0 obj <> endobj 2861 0 obj <> endobj 2862 0 obj <> endobj 2863 0 obj <> endobj 2864 0 obj <> endobj 2865 0 obj <> endobj 2866 0 obj <> endobj 2867 0 obj <> endobj 2868 0 obj <> endobj 2869 0 obj <> endobj 2870 0 obj <> endobj 2871 0 obj <> endobj 2872 0 obj <> endobj 2873 0 obj [/DeviceN[/Magenta/Yellow]/DeviceCMYK 2877 0 R 2878 0 R] endobj 2874 0 obj <> endobj 2875 0 obj <> endobj 2876 0 obj <> endobj 2877 0 obj <>stream H63cC ZI.+RHHP(.MB(3*"3]t9.f0*QrM4iLr3  `PR endstream endobj 2878 0 obj <> endobj 2879 0 obj <> endobj 2880 0 obj <> endobj 2881 0 obj <> endobj 2882 0 obj <> endobj 2883 0 obj <> endobj 2884 0 obj <> endobj 2885 0 obj <> endobj 2886 0 obj <> endobj 2887 0 obj <> endobj 2888 0 obj <> endobj 2889 0 obj <> endobj 2890 0 obj <> endobj 2891 0 obj <> endobj 2892 0 obj <> endobj 2893 0 obj <> endobj 2894 0 obj <>stream application/pdf Detralex_gem_200x280 2023-09-07T09:17:56+05:00 2023-09-07T09:17:56+05:00 2023-09-07T09:17:56+06:00 Adobe Illustrator CS6 (Windows) uuid:5aeb60dd-27be-4128-b9d2-db9e676c5e0e xmp.did:BE06F5C3BB4CEE11A787E9952BA57078 uuid:5D20892493BFDB11914A8590D31508C8 proof:pdf xmp.iid:7c40ccc2-a979-425c-9e50-df823c15b06b xmp.did:7c40ccc2-a979-425c-9e50-df823c15b06b uuid:5D20892493BFDB11914A8590D31508C8 default saved xmp.iid:bf2ccb6f-f314-44ad-9924-dc573d830813 2023-07-03T14:37:32+03:00 Adobe Illustrator 27.6 (Macintosh) / saved xmp.iid:7c40ccc2-a979-425c-9e50-df823c15b06b 2023-09-04T15:50:41+03:00 Adobe Illustrator 24.0 (Macintosh) / converted from application/postscript to application/vnd.adobe.illustrator saved xmp.iid:BE06F5C3BB4CEE11A787E9952BA57078 2023-09-07T09:17:51+05:00 Adobe Illustrator CS6 (Windows) / /Volumes/Macintosh HD 2/DS work NEW/Servier/Order_20503 Servier Detralex Detragel Moduli/Links_Gemorroy/Detralex_gem_200x280_BG.tif xmp.did:bf2ccb6f-f314-44ad-9924-dc573d830813 xmp.iid:5cebb937-3a87-4278-8baf-20cc650cbc15 EmbedByReference Detralex_gem_200x280_BG.tif Print Adobe Illustrator Document True False 1 200.000195 280.000136 Millimeters Cyan Magenta Yellow Black Default Swatch Group 0 White CMYK PROCESS 0.000000 0.000000 0.000000 0.000000 Black CMYK PROCESS 0.000000 0.000000 0.000000 100.000000 CMYK Red CMYK PROCESS 0.000000 100.000000 100.000000 0.000000 CMYK Yellow CMYK PROCESS 0.000000 0.000000 100.000000 0.000000 CMYK Green CMYK PROCESS 100.000000 0.000000 100.000000 0.000000 CMYK Cyan CMYK PROCESS 100.000000 0.000000 0.000000 0.000000 CMYK Blue CMYK PROCESS 100.000000 100.000000 0.000000 0.000000 CMYK Magenta CMYK PROCESS 0.000000 100.000000 0.000000 0.000000 C=15 M=100 Y=90 K=10 CMYK PROCESS 14.999998 100.000000 90.000000 10.000002 C=0 M=90 Y=85 K=0 CMYK PROCESS 0.000000 90.000000 85.000000 0.000000 C=0 M=80 Y=95 K=0 CMYK PROCESS 0.000000 80.000000 95.000000 0.000000 C=0 M=50 Y=100 K=0 CMYK PROCESS 0.000000 50.000000 100.000000 0.000000 C=0 M=35 Y=85 K=0 CMYK PROCESS 0.000000 35.000004 85.000000 0.000000 C=5 M=0 Y=90 K=0 CMYK PROCESS 5.000001 0.000000 90.000000 0.000000 C=20 M=0 Y=100 K=0 CMYK PROCESS 19.999998 0.000000 100.000000 0.000000 C=50 M=0 Y=100 K=0 CMYK PROCESS 50.000000 0.000000 100.000000 0.000000 C=75 M=0 Y=100 K=0 CMYK PROCESS 75.000000 0.000000 100.000000 0.000000 C=85 M=10 Y=100 K=10 CMYK PROCESS 85.000000 10.000002 100.000000 10.000002 C=90 M=30 Y=95 K=30 CMYK PROCESS 90.000000 30.000002 95.000000 30.000002 C=75 M=0 Y=75 K=0 CMYK PROCESS 75.000000 0.000000 75.000000 0.000000 C=80 M=10 Y=45 K=0 CMYK PROCESS 80.000000 10.000002 45.000000 0.000000 C=70 M=15 Y=0 K=0 CMYK PROCESS 70.000000 14.999998 0.000000 0.000000 C=85 M=50 Y=0 K=0 CMYK PROCESS 85.000000 50.000000 0.000000 0.000000 C=100 M=95 Y=5 K=0 CMYK PROCESS 100.000000 95.000000 5.000001 0.000000 C=100 M=100 Y=25 K=25 CMYK PROCESS 100.000000 100.000000 25.000000 25.000000 C=75 M=100 Y=0 K=0 CMYK PROCESS 75.000000 100.000000 0.000000 0.000000 C=50 M=100 Y=0 K=0 CMYK PROCESS 50.000000 100.000000 0.000000 0.000000 C=35 M=100 Y=35 K=10 CMYK PROCESS 35.000004 100.000000 35.000004 10.000002 C=10 M=100 Y=50 K=0 CMYK PROCESS 10.000002 100.000000 50.000000 0.000000 C=0 M=95 Y=20 K=0 CMYK PROCESS 0.000000 95.000000 19.999998 0.000000 C=25 M=25 Y=40 K=0 CMYK PROCESS 25.000000 25.000000 39.999996 0.000000 C=40 M=45 Y=50 K=5 CMYK PROCESS 39.999996 45.000000 50.000000 5.000001 C=50 M=50 Y=60 K=25 CMYK PROCESS 50.000000 50.000000 60.000004 25.000000 C=55 M=60 Y=65 K=40 CMYK PROCESS 55.000000 60.000004 65.000000 39.999996 C=25 M=40 Y=65 K=0 CMYK PROCESS 25.000000 39.999996 65.000000 0.000000 C=30 M=50 Y=75 K=10 CMYK PROCESS 30.000002 50.000000 75.000000 10.000002 C=35 M=60 Y=80 K=25 CMYK PROCESS 35.000004 60.000004 80.000000 25.000000 C=40 M=65 Y=90 K=35 CMYK PROCESS 39.999996 65.000000 90.000000 35.000004 C=40 M=70 Y=100 K=50 CMYK PROCESS 39.999996 70.000000 100.000000 50.000000 C=50 M=70 Y=80 K=70 CMYK PROCESS 50.000000 70.000000 80.000000 70.000000 Grays 1 C=0 M=0 Y=0 K=100 CMYK PROCESS 0.000000 0.000000 0.000000 100.000000 C=0 M=0 Y=0 K=90 CMYK PROCESS 0.000000 0.000000 0.000000 89.999405 C=0 M=0 Y=0 K=80 CMYK PROCESS 0.000000 0.000000 0.000000 79.998795 C=0 M=0 Y=0 K=70 CMYK PROCESS 0.000000 0.000000 0.000000 69.999702 C=0 M=0 Y=0 K=60 CMYK PROCESS 0.000000 0.000000 0.000000 59.999104 C=0 M=0 Y=0 K=50 CMYK PROCESS 0.000000 0.000000 0.000000 50.000000 C=0 M=0 Y=0 K=40 CMYK PROCESS 0.000000 0.000000 0.000000 39.999401 C=0 M=0 Y=0 K=30 CMYK PROCESS 0.000000 0.000000 0.000000 29.998802 C=0 M=0 Y=0 K=20 CMYK PROCESS 0.000000 0.000000 0.000000 19.999701 C=0 M=0 Y=0 K=10 CMYK PROCESS 0.000000 0.000000 0.000000 9.999103 C=0 M=0 Y=0 K=5 CMYK PROCESS 0.000000 0.000000 0.000000 4.998803 Brights 1 C=0 M=100 Y=100 K=0 CMYK PROCESS 0.000000 100.000000 100.000000 0.000000 C=0 M=75 Y=100 K=0 CMYK PROCESS 0.000000 75.000000 100.000000 0.000000 C=0 M=10 Y=95 K=0 CMYK PROCESS 0.000000 10.000002 95.000000 0.000000 C=85 M=10 Y=100 K=0 CMYK PROCESS 85.000000 10.000002 100.000000 0.000000 C=100 M=90 Y=0 K=0 CMYK PROCESS 100.000000 90.000000 0.000000 0.000000 C=60 M=90 Y=0 K=0 CMYK PROCESS 60.000004 90.000000 0.003099 0.003099 Adobe PDF library 10.01 endstream endobj 2895 0 obj <> endobj 2896 0 obj <> endobj 2897 0 obj <> endobj 2898 0 obj <>stream application/pdf Coloproctology_cover Adobe Illustrator CS6 (Windows) 2021-04-16T18:23:58+06:00 2021-04-16T18:23:58+05:00 2021-04-16T18:23:58+05:00 xmp.did:8BF2FAAEB49EEB118456ED4A982593B8 uuid:0b170fb8-0f3f-490c-a00c-80f6a5b3cfc3 uuid:76F3E8818FACDC118BC5DD6D62F7F24A proof:pdf uuid:adf31610-2fd7-4a43-bc15-fbcd991adea6 xmp.did:4FBC6E23B892EB11AC82C82BBFA32BF6 uuid:76F3E8818FACDC118BC5DD6D62F7F24A proof:pdf saved xmp.iid:9D37E8767C38DE11B2DFA859C4DE7652 2009-05-04T11:23:28+04:00 Adobe Illustrator CS4 / saved xmp.iid:8BF2FAAEB49EEB118456ED4A982593B8 2021-04-16T18:23:57+05:00 Adobe Illustrator CS6 (Windows) / 1 False False 200.000195 280.000136 Millimeters Cyan Magenta Black Default Swatch Group 0 C=0 M=0 Y=0 K=0 CMYK PROCESS 0.000000 0.000000 0.000000 0.000000 C=100 M=70 Y=0 K=70 PROCESS 100.000000 CMYK 100.000000 70.000000 0.000000 70.000000 C=100 M=70 Y=0 K=15 PROCESS 100.000000 CMYK 100.000000 70.000000 0.000000 14.999999 C=50 M=35 Y=0 K=10 PROCESS 100.000000 CMYK 50.000000 35.000000 0.000000 10.000000 C=66 M=46 Y=0 K=10 PROCESS 100.000000 CMYK 66.000000 45.999996 0.000000 10.000000 C=0 M=0 Y=0 K=30 PROCESS 100.000000 CMYK 0.000000 0.000000 0.000000 30.000002 Document AIRobin Adobe PDF library 10.01 endstream endobj 2899 0 obj <> endobj 2900 0 obj <>stream H\n0<l纑RK)QyN1!pT{9~ìq~V!_[:R~ϧ忻S:>ƬT6s~<,{pVãifUV?%x/eO>)>yfש|lgUZUtՙ}[x1rQu&.KonMޒV'RQ5y n%CP@ǔe ـ-قWXoف7 o,<Ѓp]u My[bfdfd9}1CvǼy=8xpяG?4kκ[iĖ^f S558T_OZT7 endstream endobj 2901 0 obj <>stream HlRkT>s!(Q$"UVWh]k&$ !%PgW H-HrYYXm֣-mWJw)m;8i9y/<ϼpaGv}h\)j&'KW5,sΏx!O9[=75=c_D3P@bw@]p|R@TO9A;p0[` <4x ~\(:npP uVXa/_yn9!A6m|BB(6vn`&ŮNv\̶HXL ;%d@Xhh8.`;6٤"jq1cCYJv.M%l`Qěؚ Hd;"f eeJX0K "f1.?ٚ]+a\IW`Y,g J%8-sqW[G_avcGGG '<3w~˵^'sc1iR"!'Cfrȴkn`=vm Vܳ߬qޝs:z:/]CgIg: 9Nͤy^ptz̓˨Ge<"7G=)w|(M(vg,N&=F w7o& zM(t:HUo0U6JUgc0T'Q䱆bke`5pӡlA|hڡ!2r)wz9|cmbz*&j \?qP0gyd;(| 3|&*!Zyt[yCNB?c[z!=xl@ I1+;Nj 1 )?[OM;k+Tg;k*98|+I7@/ӟf˘󟦎[;(:9^ ƒFџӺcV< HaɡDef_2[$P{9Yz6]h*;͔')/U̡ê%+.g;+J4Fѝѝi*yMW) ש6I=c̊;d,V&o O9LI^iHtSzܫ.&[C_gB VpDѿ@=',>;-O=KܔS3>w7#&H)-ZiYC/~EWb [>%H66(?-S,&S\ANw´VBIORUy#K8v"ߩƹWy>k7;CVw'~LBm4ۼص4Z<&n x ` '8`zw_scxŽ6Y5L5et4?(ty/Aֈ$&z悽t)K:K~lN3>UBh-H 렒l n~33 ӂ2T5!o:8#5e[!zsu%= 3 |BO>H D7ܼHExYS6$p͂¸!)pag| 㟻l!4ds'^T6Rr:L !9 mE5˳esEL8v+>NZ׊P8R!_ ; gm9!WLWpvX\YA$}8|2n?9V1̃g{+vj06㐢X:[C_h_6NF!y0D%[ía ՘iޣYC+q/~v?)ț%8< `(wGې]}F 6\,?Ft\ 82(NR^՟]ܳ"ʣZ~b:}/^6;z@u5n:02:3J`)ېVD^m~U*Mm#MFmt?'1$3F^lvR;O8Kf'w(SEgٺ@Xm('5]Rϖ ^Blȟ ! . 4t OeȀ |B8+8NdԓmY<4fMsIGӇ_.I Te01zH1IS4r^#4bQo_̨ҜX:NZ^fjٰ}qf]]U~a>벗XC}b1_AMewx3 hM{wenE`֎j ./D< I$/oވƘf;XPXlnK-bٮߥGgzpڎmtg:;{w|fg9R!ʐN2٭@[NJ p7`8 [ʹvjuV./䐨 VޙnQw79P7/B}9$RR% p:G]uA0SDq+?hzE8]qO8D%돦2«oBe];8A_5HK[J7iS=)i9#~SPk CW $!S gHȠQ 7L M`]B\#iy UQlmc+5,r(H氘>;qA;(oSɄce]tQjJ4-L6IvUƨk nr"O)gٗxC"uҦۤRK/MP22m RrZ"m|l+/z3iF`P)bb Md4g8:>^Mv;dQn͵Ʒ˭rS%`)Օ1X,5BUc0gclPއ&0Ixctk9I7n7Xn`E&^NIf^.鲨,Ymk)n'D>63<d> 0`M?v|,/Z `-A&gP :8` 25%]E( JX\X_O ."|y TB  WptL؉)G +!@hbU]rv)@d0#Q:ކȷ? ÆI8lW2B] Υ F1›= ,5NUMHb߀E$BGNƠȷ? 1c0>9|9ʁg!#۹ͣЅ[M<f[:zȑه e:q 8l RNY̐clu!KYFa4W(x5rGrR&2m]U<#S(;YƆo_@jz轄JzK:W)C;SdjZ4J|A:IX9}AfXJ <OH7A7"Q!@JEwv* S?+zF++< _'`Rl[C__VYg g,vө$/dmP%;k]C}zw9q(* RfN2 sN|ׄ,b/j%d6K 3w3޹|6K}45jULjI~f?7P0t}}jEzX9+L6 /ơ/^q. T4-3ȿBr H4l]ٽ>*v4C X6γ t^v>Šonb^c%Ey.ּ_je'lUh:zC K ~ΐ:mOaJ2jkϙ^:|~V^,z[ז>~xⱯޙK;3[{uҭP6Ҫzy#hqvu-ݖ\CmCkEWx e:*_M.6k dT<*z9D߀A[c)Ie`jEp0&#B^ &@)/ʦҲj5-t`"U~ēNKEe{PP?z}$+ n^/K(K@h(Eo.K6Xj]A!m*K}(X N*UaG눀w0t9B7/q="TgRez]W^p|pWrkT= =r7g<^!88!H3oa-vHdX VL  .`I2yetu@x0mtS!.v`5̙:lӟwI^cmzm `1'HEFMRFg0+ \悖.ȅ %;pu24UU`npzyHLbTcAvZ.䮹n9_pE atF8iOa)]jal8؁Mǫ]z ( 2"x @HPZ>|s~EfҥI0HS㧬X7ƅp6D'К(lfA7ƒHN%p"mfl|D5 obBf/oޏ`c6DYv!ZW {pZfc-ZH4`rHC(TkәR--ӟ:af8]s׍8ynbeoO>$ F]sgIOt frpHʨF\7$@3F RFOf(xL0"lU\g+r329N)-j+ Fpe0S2:Myb8V#OQJšb}'ᣆ(q:Ver*4!Q%M\8&\xz~3=7k7şd%4ɆXCpquIN>=seTHh2IpRT_h9~2y9V̜A/ѝ WwȂgCk9 !c1{4{_tt4!hp@lٞ￿ldf)$ @gw < [Z'bMžSM=ͶۃAtKOm-lp& ^7gph=, ??L![Y +I$)"_T<7yBNm^#/PZJ$pT" xU>wIb4q *+Rʘ"T⤌l:+H x04P0HYj:[AT*18I=e6ΫS#yFj1J#5tZybqbAIATAZ^jiCdXA8jR)pSϠF`B CtAjH 5<4ԏZK 5b!+ר^BsQ&A :I%h`fWm|GW<+1R:tZa[t`Y@N?ghk75_Z<|5@_xR"}I8ExC_n)͈<VKcCm"ZWw8]Ic3bĻcb5"%,3$^ mZEF!73_=)vM| v?~ b'y|8_u;#7C^'Z9@/]Q'٦O'w= rG|:Nί d~O.wgRCW;/0D_1Ƙ}MkT-'9hLp &6 pa;Fd瘦ڀB_>z|CdIC+=cl^D#w?/ߤT+wfYA<hl{OL~e~>"o?~;| ~3>1Gg}?#[woq߁^_ |Tynb>ƮY%WwNl8?7͛;o WOInKN9{݌=~W-pd`=e"?_ endstream endobj 2902 0 obj <> endobj 2903 0 obj (/D/Work//2023-10-18 4\(86\)2023/temp/full/CPL_1\(87\)2024_cover_preview.pdf) endobj 2904 0 obj <> endobj 2905 0 obj (/D/Work/54@/2023-10-18 >;>?@>:B>;>38O 4\(86\)2023/temp/full/CPL_1\(87\)2024_cover_preview.pdf) endobj 2906 0 obj <>stream H2P0l.}`b.S3=SS#BQ*W@ endstream endobj 2907 0 obj (/D/Work//2023-26-12 1\(87\)2024/Print/PDF/WEB_RU/CPL_1\(87\)2024_block_WEB.pdf) endobj 2908 0 obj (/D/Work/54@/2023-26-12 >;>?@>:B>;>38O 1\(87\)2024/Print/PDF/WEB_RU/CPL_1\(87\)2024_block_WEB.pdf) endobj 2909 0 obj <>/Resources<>/Font<>/ProcSet[/PDF/Text/ImageC]/Properties<>/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 2910 0 obj <>/Resources<>/Font<>/ProcSet[/PDF/Text/ImageC]/Properties<>/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 2911 0 obj <>stream HWˎ$IWTN<#iW8ba$A /afU]#jȌyڒN?{!f,sYwOyϗ_xۗ?}a}cFĽZݮ6z< koiO]ڇ㊿lY0oŊo}zOZTm{]{*>pVԸð} =خe^+/w;@ܸm7 |y (eñ/k[[(Q.sH.wV6e}XٮF1<{CHnSƞ<vIZM73 ׌u`?˔|$[5 վ齾= +s_K*|pX҃v5*NKpzcnS8ooH䟞=;O8G")i#.ݲ'#& -(;צe\v*{2LKCJs8HL+Z/ڸspCg2:È=0MߋRhTZ/n\~ xN!=Wr"@򘼪@Y]Gքq~(2EO=E歈f?rke6z`J1ӘFJĽF8flXGpe@B~@,- Re|R J'$%@˳-Ę=crEN8k;spT5(㘅t8H9Yֳ6Ze)=611iL>;3 aM`5:2|SFQ|K< H?xL|} u )t9 R6,57RWzX^&'Z{@ xDgBh k-Jz'_&Q;G n=Dk@@ZX| _6TӇ[yQַE9HTm-E^ D:h`6 ZN߁*s9f2S|.; _ 7Q7+ [Ip;A#&=B5\kVN' wD ,ޏZyH@4_}?])YԨP#FA525Zzq֬.7H YoQ|~:MHAr:p0BӜ+]GL 6>ɔ\%lt$Ml^ h'R@؎׌ A>IWDg<7^zqp7=8ÜĻkR'HR1S W</Vc`F#%JŒ҅'ǐ 7,{\ l&2n Sj731Z98"Â,!Qsշ&8$S%I5l7[p aK} WTd~=U tI"*JMU4Xw(is)u1uR.ҎQD8=N\+ՃXGU-v|՗Г$mʶ o䘸4>9Bћ&.& džxbL21L*yצ/JoSso %=hC8I[)DܤIcnKOkN4O©N zVꚊb \=6T%ӳu.GF"̽|G.Z;墱H _6fOu}8u/אy̚T~ _D1c{AhFWz='OEϢn!d[!2zIkP9gƭ#RRet#$Í%IcQ¢d mNƪY"2NeZ2/@0CJQ7XTS_ho^G\頌9m*ucԆj!#)%*ԑ#X-Q@%@bsbI`נ:쬩TB!Y8 DfTv~9Dxy|@.JVuzrne2 $ٻ8#"}Y_S<6ͧ8if;Ԙx5!q 3 ΈVW}!=Sž-sTFS|`ͪޞ/0!=Œ_jgD(2J";ֻ!^kQfXGS:]bάwwQ1ߞ|2tJF?R!Oz=[K~ <~ `z@v֚m ^o_!t|}K$5O${ESNiaPY NXU˿"QA5.ݴ*D$[9C+lQ]x=/ݡ$I[hb[Le ̡w1'JK=o~5svh>4u :YYgma'(n=-H򗺔> =b Lp,n:UqV$rKMZ:Ylr,K-lnSnySjѹkxD֏ *E"R){#=q)"W"ҽ\E~\9{}$C;+/=22~oNw`%h8 {XTdbՠIwSo2%,jlm\'EQ^! L'6鷷{uSdQ'U5ҍP\ݯ/΅suD2z ~t[Yu]cDps0݈[lZW+5(FFfɁzr> Y/˪8|Y3 sEXbiUd|•0D[#2lɔ`*+݈ n8mo3M(WI/ƑdL~U&b&f5eL”oi$&!7z@/jV,I7T0v;`KțTݠmCcE߅^{'~V0 Q;c&Kɮ.P|-jgFe^-DŒSfȗqci+d|&Cp {4|l2>R.|_Y u$9'7DhJSnۧZYiqߍO5e i2a4 RCBjX|J\j a-\҆(i*Wr@VtKBxRpk]Vƺykfc+ҭ F,`Oh.=1`SC}ixH$>T+(;ωR<_SmͺҴf2KiqFv iDq8fiO y{}ˡ}-)RQ41vfs_YPPmzi& K8j-h9%%os]FMLLt& D] 5Ҏ_:ܐ#{3nL6Q_<*w_-:h ҚeZOl\*9t\xD+nnϺDmDuёhZ,5c뱙n&^c}l؛94}eӶa]c~$٭#O Tt_7}EH*9ڻr1$9HvFf9.J=;i͊Ӏ" J߯~$BxM@ˍQ~" rŝQjZB! #/}{Sp4.S9Y4XCr *=kC50utK%I"サy_*.m~h7 Z4(WSuU.ne w q|TUXWuug<L1NodLG7Q#,J9=ptO䚎9%%3&äaPŪ DP,4(ͯ5Q\z_t#e*Za}N2յ Ii[~(s+g)DsW%K ܑjB[).QIًA`kFh1/cc7נ2 wwYX| kտ6x렚ԯy4+~'IP6j(roJPsyvѷE">7^edUĘk^<*_rn:9t=Y`) A|1heN4С0;q헉J]_{Z0˜لL>@St>.;w5&"A>W/|0}X c`Ca<:E̊͞H,؃Xen ;9]@r Fȳ!4P:CGH.^Xu{"m=2E&콤`X֟F9GqOj/BRŪ&xw72Õ% ;$Mz9HNqLnmCV%[rꝮ{BCny'RˊG wGfM/>bbg^ 咽Co9)]+%3 Q*.ϟ2C e'Z&d9úlJ QŋкG斝9({ֻxہ1ڛ-D$/FVywBJD2Pl~u}x`_'3teadnBi)(KEJjLs oPnx vwN"nm0|Qa~Dž ٢C ޡwdoQ*(& 2ke0~3Auţx WYTD9cѓ\Chsf#q1h-͓Ûnj.ARm5W v Ჺ vV;]ُ/m <;΀Oa+CPbWTA7-0_]i#?YC+5>Lt$4awchc>̕ӰW7핸1Zoc/Ѿu-[8`e(Fk*߹"ʿT`ސRE}Bt+]6+`K>]rE>,I"uA)HMMXH}m [` H&;&%\;Ii;LThe>{Q Frs ]|Dv|ޡqh E.<[㬓7r,;™8}yq>) VC{AQrào1OzB0?r~̡SĶO9Q@K7kYF/L"=?iל)}UIDŽ냪\8swBb. iH#WџgCo}}UrK{uf*:BOKٴTr}oÿ Q/Tvt]oEMխ*I䆁w MsLUݭc/DTW H$U"9D%cم-K*ۓjjUBwE%.*+[TP>,3j+RA>S`I%̩:(֝1HІg14#1L&ZZ$xPh&$3zm,X;E{3xJRU^c(g!BWgjls9e+VBg `c"kh'$l$8<Շj XwRdŎ ɬY{| MCnq^T4{gE <>ay2SŅ2{ai:?\G*$ py|UX{LX &|Џ4M]K2p!C ye q++f:p2,zYe /;f*.[2I#'IAD:]]"؇82UQǚhH*JܝKS^[OKmi*譥oLEhW} 1Sy*u]ˊT;SƷl͕z^PH-$C!\1(jOHzb"x&Sr ;&izk<:SIf~"Ӷ@~F&Z/4¤&uL(TPD{],XiT͜h;gȁk= NUtZӈ7 ; z*ߢ9E|w|&|d&*QVk#boƋXz1-NA'jrNsU׸q7-NO^9 ŢXsMaȷb:ԃCL,h5J\XL #1L&5\袅yHuk(u?OEО6gg8'LXUrTQzCE8ˉc2؂9C+VS&%Ž4#_hdזP2YM8 e/NtۯF:4-]|&7I!|}PrbJ0V~AoxB`6}aϣ'}m徖w%NKWt>޿w$CĀA(ҊexO.>kfsRDgdO'49stI4RQ;P+,TvqBw}-dbl%SB^q>7r[hɔKXr`P@4)~IOs%L) %WMJyBvMQ{QH_&npeRlwlSjQ_BRb - dB- " FMTÝFHج׸$e& = D]Up| S`qa$:!k& U1j#1L&ZZ$x* BGb"Tu1K%E{DwO{B*if';ʟ> ACWvk˨ɐaIHlPƶkain)1FMxZt`gَ * ֹmu25P@*fۥF fTf۶$Kz' hu.1|sWZSwB91V璉^C_KV~$ˍb.<ݙ RR=ZSEQ >DC˫Oҹ47Z2??t?!:5~[148ȟ jIG弇+Bu;tnN-xadNCHy+bYrsQQY]^A\rJ;&G##G -(VMd*q!pTDUT?eye![9SwT}~sȵ(&/>!A@; ()r;}HfݯV jJ`G25bXHtx\4C>L095L7&ʌ@rqǟ9R?5b9X_шǦА}urT{gJo~/V1[feƗPdl##^7ǿQ Q6D0DU j'i26pvAvg VNl*g0U4Ojp4/kcw ):M*,b/6؞)V{$D8W煌XCD>KR0|G |4<$u7G }6']u N:suڝ肹Uq #}3?$q֮v)~Ǣt~^RB}}Q:=lbfdZ²M#A&b dX:0Da@b*I0Rg"n0┲UUQTr/-IޒkKIMIt=rڷ̩F 30ϋSJT 7Hg>+7Htn.\LY?)F@)=-GYҮ2~b_Xdz*gՁiRSFwB0B;=v|W2кT]pl'wl J~ň-݀ 1/gʞ ]\CKDh Zia#j=3%uqb'CO'qpp"d0|3dij^@|`=oT,:n*{nz@p} )G 9)XGƩ|i11Xl{b̾iy=d8 P[k] ,_C qO4ivt`Z<2p& p5->$AS Ƹ:_LW*"x3rV,j=R@K4z`w)R- Fqͼ-,̊$l pT8 T Y:ԨXTUdeq?.HiM o:K8\W: VM62{̺ǁC |w f|L5:Eh[kSl)4(fhQ\'&/mOL\W[c~~s 29dD~@&ޱJoDB9+ITT'|gPG{ 2!]s+QPq@nt D١[o|~y`bp;4_qL`ssddo1;sd`S/yZs~qOۤThc\UUB9r=QՉuR-@8GQ#TyMuO9bmtE]C#! '+EGRp.ǤduoЖ]@sFkK P4P\͓tS앲Z#I5ӕv|#'@ҏwY?3%S-id?MLZvav ]xӣUddޡ^$*%GB^a-Ҟ$1QFSъ5d5Ӛ#R+;IИl]jtFbfU 1(#*m/PHI)0ߵ<|C<tCr8/)VT|p /_oz' 9U}:95&_F:)55E?-g(Ko|nss8x[Li?hRA)8.GiҪ2~5i4d T}TߘQ2b;XSe[{ځǚ *ᕍ?6f5}۟4QJ `x~㎍A/8 HuR!?G)x9o 3>$EϿ./[Q^'e sdxIj^.s\ugz{ =H/lYbY3(WKR.i1uKTZ.9OF0yu%ʒ#I!D LBW >(B]m@Ho'NB(EG]nqJY0Væ9U0w37$- jig~kTgJA>.+Tsf Y)`R@`8O1I6R¦IP@+Pn>b25d=q[_\굿*{UG[?o^+Ɩ hڗNɺ On\ :\Q88cHw'd?Bׄn#jԽuOia*EPg͘[؋{y=T=͈5̒"(Nbtj wj$& ^$eo!QmKt/4dˆ:5K 0ZѵJ٦tS70ghrGԭ"m 0#e2cz+.P:1CH8kCUz6A'R'1V|2A/@4cz#MNp=Ijv38)oPpP4Jګ-p5p-<12%ycFj¤D }4ʁC)i^sj [yLT%ESDϔn|ƹ~%_ @#QNV2 | b6u&J$iU"ݖXD߉̍,1v}o`Ɉ> xg1~F5G|c;M:*B?ID)HF蕔ѩwR)[5 \$r& Ȗ< ]yLok"6gՂ,D4RӶt(zDB@`LȞjY _17o۷ޡ eT H̡r3*Phn rW2UI?C%1SZ$F6x޲ #B4|\!.E%!BWK WXݫjrY^'$<%I^NlKIXҬ?4ӄ,&VDh@PL"^߇UXm;3*S94{cdġSu㘻BT <\ n!rM5#x:`om\ DHt*bRU!u9R4]eQ̚I`jj`51ڳKÖeV6Aut̜yV\f K#>_=ɼ qSS>Z/E]T d+ʕe3b蚳O{fV˶?ԩ%aSBGa(Ӓ2ŹEeQ}+`k ֝_:/EG4P?̪/:I1Gpjƈ,!?پb-W˂rĆqVh]#8{Mf)0Īj@bTo;Bs&ɵ$?^|s>&d McgҦ/~UMYXbK͍0h)k/^"g4|VYҗbtIWs<| 9oeBͿ BH`ĭ8aJ3,4OW% C2AK UNp6?:6h2Ԭiћj\Qo+gߴRߞȺym^ù=;yisn <ۍip1ys\U?9x9\cA`2U!).ma,S-ዊ ϯlC*)TSC5mNM*4:I'v£s֨dOS9UbCޞZhE8gJ3GeZ%kYѡs 87a!c$D,~ Sv ֕^qMtRc/Վ$ǎ}B?<1懬n>S!k]5,LO3DpY-q=E2!TQNnj;~<&(qmԕ>%M;#O N ?_Z_L-t%dGȽa6Z6c^q9yףIly#͚'18B`jq8QjLv掛Ռ»Nr_hK467xp2'I^Qzkeif)m ۰XїpO *oy0,~\>x9+NՊ"%f]Fw5n{\ !bǽZ> 'XFzWHb+U`N ɼYЎyO\a6pDLgFʺ&L$ 1ߊcTE2k4IeCr$Тr.ҨCh^,l[Kmb}ɺdh_b+`sئSo@xZh`!怣@xP'MFJ!uN6O cwLrO=݋Ij&d~w$0(1 H.e'{g(*\. H7a.CMY3Er>,J\˸DFXcH]T0 И!tb% Y=zH} zG-{nVכڿ-kFՁE*#Q*V6VhTc+jbXjB1˨I')]'ˊ L?/;V#m`p scCެYuHFs-F9R\I66e]rqmɊP)[ cߖ3l\)qgEy9'zoE#mj:a$2ANnKH Hz6bsOɠ#pm[-әCx*T5%inSFMmXܡW+>b{W&a[Dmu =BS.Uu .WQPT AqUkӗ> s@¯)z~|Y?`9P&jĝPMu`&VOߜ4cJ:ƿKA؞ ?<5ٯwn>x7 9l,8`qӚ9Ciҩ>2G\ѫܰBje{aOֱ\o<)d6~U.K-ǀßT#ۋeIf#U k}7WZ$^*@5)͙mXWQܸ aJ5$jDekC6vPBIfD3v3MʹaԢ>mHrٳ5,L9MAkՃcqjj:vclw Yʧb -9W_\\Vvuh˂d?Vžoz/zMKaG_2?+X XWQͫąDoUIdmW6$  [cMq]zde%ye d eՁ S=$3?}v^kee'ʧj.(Kw2>=@hp,)Lعr M#N[ udtkRU(D0z+?(ֲ'v"FS U&ΞO@'TH8 *dft'i07 r$ۺw0s%ȤUeuMb4ީXt Y}\G2D2t:AHJX"?t)fpxfW36]Fк P ⬂%DV,`X/6;p@lI | V{-̳t~7BS5TkѨpsV˝$\ &.Zl3(iٵ ]lϭ:R3Bmg} h>Gl֮̚!a9da/|EcCk%2O׋MoY6f)~hT)v jzf쎕{Zx{,1=)4Qh}khHʇ}pOcxtWaEBg=cN-9sh!(6|-τfkTv%3`- 0=O9Z`%`<{e/~N\Nv+̮52b B`Q Y%>h[˼"7('XME>f>ww 23w<;>jn,R.t K}TB3}ᚬm .%lt݅FƉ266N8z␡"[i9XlU֍U1lෳ5ZP],RdM-{nI&E'NbnI̜a:;y b(Nqw20 :*>WhJyq~౓>JWoSSnnAyz%4Ho9}9©$OR} JP *3efqv.+S,OnjtlG0dbr2>w+]U4,exPD5fS8\,A(OLI\%gVЀO *32uq95%.h)źt+Zy9c0:ϸfTb~XYhs|%_:d _cd e8D:İA > +Ïdzq j!%FLycEc9Oe)o1H|MoJN_:jqykkNaKB(J7Bӈ!Knŋ-QDoQkX LzZ򕟖́ l Xkoy4_EUL鏅r+8%KG~h 7׺^Ԋ߮^Wd9qu4&OԊ OԨᵯIIW-h9i> ǨJkk];U؂.RFݬ*΄Z[>6Tv]( i¢k_/d 575*H Yr1j꙱;VkExuYy? 0pbֆ+ Bէ)}XrOcxtWaEBg=c7~{y2C}JC@ [3qN,٠~5s3pCp԰+̎ Ġ.ZՐa`m) G:16A/ź2XL2"ZDYl¨#Y%9<`/P8QKՆD8Q]s*92VHjn~]VuU줓8AgfW۰65>rC$$af! 2U."ڡ ˘ʺ1qؒD7;M–;O/wԪʿHdd>.7f&O80AS}dR0G3#0948#34{]׏(23r3,IGVҌgeu,BQz׼N!@[:`T9ل_v9[\ʓtA|+IJ"!qQ 3+hh,gB3& Ӗ}=:B1z WM f|53\M@ hG s@Psx>qoMa@ 8(-7Tnį L+KrilOKD/y ka>_i\3.w}7ܿ렐F[ȫGHٯ\9n)|1D1%bﾰRԏ1o$ /6J ڊdv58P L"qfc:+?^+3ȪqB=GRPui0]_wTeOF˝:5kH/3mS?Zt&JS֤[Q*ڂgzzskd٠}Iu! 򖅇A Dx%3uEaj9񀇱v D>}dQi e^27QƘ=Ťys %Ͳ:sa)p\\R𓕉mT 4lfN׋?5$8`L(!A&D] y+c<_bΛ*xPq?UpBAۏ?ď~9?2i G~g#R-yҿFFQJπEeaBo^.-b?I.E 8>}ܸ_g|wKq`Y RA^!B 0?LSbD2 K0$&RF C]aZWbQmI,xY>1y3޲4kjL!4ٜ Zk{U Vm#w*  C=sta., x{fKo[Nu3 H4vS"d%n T,>sBtߋu.)dr.b[`wG>uS18[C-.^!1N;@Op/.S3ǻZkw>}kGZ\"\v@\Gfs~6nY^Iȍvc|}NB yp;K@R!q@ˠɔR.7SI5UDxBk(CSQ}aAITA'<0_nj+ꉬ"=Cˀ9Ab>דƄħm > )}\|a!LgI*t _ % ʬɊB]"k Gjz{} K]' oj|ϏI_m^9*u@Bi^^a ,.e>)4)Y&-T A fNf^8$U¦ͺdjtvhޕ1jssd(* թZ˘ʚC}^xҲµO//vԉn iw'45+B]+U_w]-Njm{ɯǯ--?;VL.!"z+}$NJE|!8@Imbb Xt C%ppX6O끃+mMÎa.L`Kze '޾TJba]lD;y 0Ԗ%?N nȽ]OBo?aV >XlZvેX蘷e[IJ,W,{QY~Y^;x>"0HSw>B{3_u;y1)B#l1Xꈋ5uZk-E"O5.ьaKw?׸r l| ME8r[ Go0}?G]ytPh#EInb7ziJ;B Rxp}b}yV|5(&FJn㛴7ks0~J8({OCzI1>NjIa{/<z6 U={M8fћD(;[۠Wc34h]cŭel+nq68_5t0l4&Q6l<=PU@/]gb7^vw-0/t$gT=s_Ę05.47ʐ%It ˏF0|(M*3L.2"|l*3hhNgTZ+i{scP>( M^hʵNMc[!h#0t~%sPS&ONktE:޳SՀsT~B%g嚶dI?,)KJw` ^^T 8_Pg9c(Y4;C=#vOrN3{||S fVB({ _MPlW{uo;%pP E|3CjMXN3y}kti/O&}oہHa:xUM6Բe"Ã3Rm;G hC&;Gct(D*@jP좦6h.*xj̀>E+6;eJwLbSe>5wpV)]3d[W=EÀın$^C㑵Q֮'}4{W6}#k]ġ|pOț%2(Em\C3?26@̚FM7p6$DJMmPC壷׶ ȧ}>^aV-aQ5H)qBÍ됭4;hCetGZmjK(~~5Dž?.XR=KkFB*h MYZvAo'}.Z$3NMUFX0H=ƷxI^AkÏaWq kt< oYlY@w:"DQs5;4=Q;ksćN]l @T⓫+t Ri%zE6r|% >am?eE_+Q.|Fd0'1uEҷk'ۣ}e=)6^ Mfz=tEsח\҆NEe>kewMAPc,X.TX@1~"[|75sC;#eX'n=1)?nNr@{d|+~An0#⹳_z&+ ۵[Zc0v6N cf_` BSF'r;3 A$}hSJ|A%u^?m{Agݮ̐곂{\OZ'HW c푷mi*,9,A,3Fծs_B@l} F-X|F.z\jУM :$Vmb+uiچJ}McMG-uh4<^b԰2*V7ts-ҽ @AO3V5zrε{­]f q̐Q/贆Tڏ9(Xώ"#GQ(Os~w9d(P4a(ؓh7Cn(ֳhwCPؿ4 FOE+an\t 'ї` l*_ dgX)9 yItYF;u)ءhJyA Fu:Y,=4NpldٽDvڴJ1'ۄDB:CIA%"V2L3d3 C**b5 }lZ²XF޲q΄B ImHޡ Y;W#WCDj P VRK=|U$7 }bC,KJA2RKiLf*"I1)I[lM6{,N!Li9}oȬIG=ViK]RO Vq.]Cn `UFdܡJ6&hv?$VŬ/y\h_OQ+ovu3]#|?e\{>e]ege){_j/뽽,߰ei`;O~%ֆo? ־CkYquӖ.F$3qW+>#?C\&48rotLUKJhFkPP|Q .+RWnnV!gU,Tsƻ"6v ) Q5J}DEQaXwIq] 1)>S%u7'XI5GI~<7 Ln}ywm~1U+ZHO[9&Q/ƘQup]UBiW#kQqki{s#'ʟg@Vgz2kT TJ sCl`0^?fpAb"I[٩PDf> M ObCB}jRTGDN&-K51dM90kd{{h"݉'EfU2`}/Zt$@;DmB6mFϣCAz<M &N}|[TsSao8JIeF}O[DjneR4ar'?r_IpwݯyߗaY^S\=u>blLaGo:3X狠FG@(fV w$i dcW]ύI'A\`>ss^f>Ih &x`zJ7ԁJXV4wb{a:\mAY&ř~YdV%g-:c\`s zDs}ud7 ; (޾t=QP]2~M)oy_kޡL"ƶJO)ǃnkj*_&D 2@vLI\?lK= Rn/O|TSG_w 1LW+5X+!$ފ!}y)i9"S1 2}?0|rɁi~?9Sȩ^io}LN9b@ P䴠؇SccpA]5}%d2P snV̧~]̇<êƻ!V  *m-eYyh+c1Y uq7㼀۲(.h(<+H]#|e O?p(ãm~11+m-(_1Rok~exڋ><äVz~ ]Moru$~>LvP}߭EZu=byWm9B)CBgga~'8SV* K({tAd ‰B XE]fک3#. ȘR5WV .W^[g`ّȰQy`C0Z?X3B6𒒑Rۥsп:zSq釒d3 !u?q$fc j"A`* Kco}07k$i ߰)=T^vi ' ]X3^!Žrᶑ67ם =7Rc EᤆWI!QKBC\|sֱ2Vgw{/[= (zPyD1* Ҧ+@,K@l3M~`£YD]!Z5,FXlnprqGPќ+L1C@ψ5t0<_X3z,Fxto5:Z;\} Er*и!6ŮmٍGG T͆"믧k³ql5ô&ԏij|ɵ n ˝@zu.6SwvDD.1D;5~;D5BmJ!Eڇ $F)Lop 6{"| BHDk6a+IH88Goȸ+~pdg ;Az"/cRfL{idN+uf .qbW } o4YB_+[e c7' m6kbITI͈SՌE%l/\,OyUC8՜;R=⤒FPvhgj[/j<)y"n@G&;XBmCΓ'1\,3Ju@9~Y53~| Ubac{?u I;>MA?ŷhWlFy鞡e䤾ghrq/ "C5!Ul߼whqzBV&+2~j;}H߹~;oNw9wgӞ|mٟ|}=Ny͟}gӿ4l<YƳx79x'osg<`2SX= *R] J{WTl|t9RXn Qai_Dt@\s=gPX8~~Fòby/UdSC6pNL!@|tb#zdkwj{j%Wd[r;3@)wa R|pAPm/5"K9mI1c;Yn:IVGڨcd'ڷ(M+_vY2}&ETri1,ײ@@D-j̃XMH?HVUQC2fCAvN"jֈbUD,D.(1?Tgd]W)*E0εyK][ri˛ހPif n?"cHUJ鹤rJ2gud7f#1&vTZY2O\xi^hN3d_CaE7K)"%ԗB9pg{w5$Zk)& =53aeZnUrOuz@uS&D\Dg`-jRUHձ>r(#:n UqQ;#/7rx?&N~o9;TAm`_>mI҆&c&jiII#j*m\AH%G{ڣtDgRC(G`B\e-Sx-[΄h@.82䤽f(`yi' cPNUB-W8av"{׏*OȒ 9cb'xKV43M~/Gzb(tDј IFRX_ʲ0<.%&UAl=F .qph(Rx+! {3C㶡#m`(Ҡ#-!ϐqMC76)>oCo菼wnޖ,#WrjO#,0:ۗ{[H`x u#c!Xb5%&ViQ ~[;ie'5%6z*%M eXS+ [6E:l$[ "f>.LNj\ \[TدZnl.PZO>Ƿ*TG|? HPy>lLOA'1unwtCB+@<[VPN }Q9b>'Uo-׈͒V #\Jbo9JM <}l)OEk.gdhVtIއD녵౲8)+ŚE4j|EDz?d-;I$̙g"HdK0*{I"V3FN-\vpmcU(BM&qҥC>O48p)^QlcSKj gZI[x#dtШ[Ì/ $lO.Dkt}J ^w;g EI>an%0*qOuָؖ0DZL^G礈R[ otkְ@-XI&]%W`OnCeMhYKq Mմ<atZW*n| 6/_X+\T GG2.gC`5LWJCLOFꟵ`sN$yҁܓL:bN׉%#Jfu>4W]5(WVT'F]|n[n3|{WZ#i-Xqi2^Fw ҊFW2Qhk/ľִ~~ѹtޥ+_^3|F_>' GsZȠ}ml#j-!Qr*t8Kbʢ1:wNi4V( '6ES=`u9P^v9_vOY-%a*mAx{]n\?:v6(.Mr֔$mjiL\0zy!FXj96gsk8K|AM-uC7~d Qi'4>OD3BFM:>i|6 Z !!Rz,X[2e86D)TIu5cpuԍ,`dn{ !V:OV֧Yh-]Z&"4?k-ׅ E(-ɷ"hHe|h#Ғ( YMwr|nޖ@B7c 3g浶AZA^ k)| SVV$=H~ldz,dq~Q %c˞BEkK=w6#%OAooSEbucOvmd1+߅~7nGSs6]jB>?34skƖhaSP2zK|~jo."Zˇ"=6фjU?RX74JjpV}|^u7xm.I]^zؐ#EA\e~F(wdsX[\K`QxZ鱜QWzX'̽,UV?lb QQСRCr,vu| ӦlķFMYpQEw(ZZ ?YuygF&^Fl~uׯM[{'@-՛/qȯAY  [;;_6]bD/so0dA E'zZ(|>_,ac"eş?ŗV**VHpm8_mzD_NQGbT`4obj@ITtQu \Bh,lKa;cm&J-x-tsF.Plh# ”w<`|]4qoU3?сf쏫8_Ag6LU8]D zp|;t>ѧg'Š8l7Œ"4:7ĸ/l ђ_/KI'V?9B be Bn 2&(.yJ >㷌j-Xj%J9 I⌋vh> ُCUGH*Df5DR:Q#tv),ɚh1^'$F(ѶYRIډ9 ̒S Q7j8Pf%³ яs *~bM5Z]['# ¬ ~oG_Zȸ#}5;x"srebj/ h¦Fˢ5 '\ \VW1"@yWqd&ug_|H/F2 5tkd#Bo+k`\K\Kb)k(^Jx%?I0'u]m D0L6-aW|~On ? k4`'IBz FZ~:"~1m`OU>7*Hϛ8 `#3\%"|ѐ!@"-c?ތ=Hz;N N\7S+qG_AˑDeWP+CKNhrνMm!H'ǾFA@Lyͪqs෋ш~4؏`ւ7}Wv9B6\Z fygwymN/vf1x?9G<c>jp b&>#^hj 4?@?bzW5\5V ?'J9+NW`ʰ~x tBlbrGv3cpZ'4YwlFWK3A2IG/:$ǟaF"Yd~䐍x3t;T*ĵ̡-<\"ds[vJǼCQ֪I΢Vvcoۯ~8+Ͼ$a9hHa!ݖW#E0꼕=~u[E$J'$g{mIEq϶fkAڝ>gBlVkٯW+k&b-熠" lW>/P2`=BeG6c!|Vҡs $S!¾qHxg]ڍLC{Kd9n{9m>Mdf-A}Q/RTlrjKIk;+h49wV0XT5(E`)`Ԇ>h-؀HLױ~9U;0<2#*Tk1gƪ1"ܫ N:li|HPHcS1t|%(x}8 9РëV+_!ދ~[]0!I| m`;6($C"'Ѕ!g)%$VZtES5VΕplGvХ|ͳj'5rZiJ5 pK)[CEnN\vR3!Jx+.PD:oA(Xρv$}щ[{nU xXƄ@̈́Pj6Lo-;=yg{Ca@K5. I\={rB>*5ÌQ,q_?r?UY}gFsNyrЋ6vj^8&9eTj,;}42_bCRC@\&#hWLWm]'uK'lI+G 5d#XXqBLVUdq0S:~t6_VJy/ 0<#߮3v|AffNs Om/3Jgrjq#уٵU [7h瓦a,5‘3 V.3U5lyK+g OBȀES)gp1g+~\Iot )mq>*Z$0[ f2NÝ"δr})"ja C`%bQˠ6;OFs |c韜 }]ho\@3C)iR8K,.yJ뱨(Lk:e!1*O(^d㌞3=, ּ SYAZ^=ZWԤ=##9rly1'xF?D׊'?pShqjv)TU"[@ |U[iV<aesj!4,<^z7qekkR069EU\i6^no8zdNXيmWMZ' 1|; -)~0?6B)nat;6RhqP _S%*7*HL! -=X1l|͓Va /L kuf"=kmCGnG_mcUe+ yz? r_qvw_iJ>  Wc(B k`Jq7&(ZP7N]]㡡pD.$>F;w6ʜ>QCLx0e$%2vnaC#BAHR :v)#)DAyvfe0<=lDc!.ytɸDӑ=?ĮgRuHxg]ڍފj1yc .RxKIMɉ6$}MUPk] \ĭ]NP>IgOhIά:˔̙ӈ&}ߏNk= x}D|VvI$!#̇RvMy\g+3VIyɪ./WKd9)Y|"Iŋlh TIݰY5:,AEWS;եv]%p(@@hFOgDnWRWK< pp*Sl㨠dhh4f[ЕZv)٥UK"7V6=75E)g৹,USGXq[ I㟺EqXAID=`ܳPUlO/*ntoT0-H.*`;YآI?2nlpaYga=1cY5lmM¬S_.:_T8nTxEAlYdQ  4uK>Ʊ㹰<4V ˓=q1Uck Ur_aRDMna|9=su$^ymL>' %tGyWGo8{nutU=㪊&'RQGS`5AQʤ!oSmג~te48쿚n}Ņ"֓¶/ z-~6ɦo0-VdA:h=>d:Q,lLRgE:Ⱦ ӚI AYϋ?G ~ ґ)]0{dԣjT{:좭f޶y&ή:ߝ+BZr y<'3_t`S[0#M.i~+Y:"Cϖ1=S/8 ٨̈́.4w7`ENJ[,ќ2&HE-ń t JgRY?qx'Xz@}%IP8pN Seu/&l(zX1D_b%lqf:\'TU#$/Ehm-<$L)*!b+46~Szju!JcZf"nÛ9H6Z^v9oGTWzA ׋ifҔ,wSɍQGL\5&37=IwGr346%>.! jX=0ih/De7BVxƟR#=،7j?vݸ@gOd?!uah|,[Y'X]^&}sIalFi TJnK22ip_\vI*&RQC&ˮO , Gx-_p3n7tK7+oqGҒ F#F Qymޖ͘H! )ymOz SVf<^M'Nijs}so"DQ3N-ko#J4pOv8m~k5gb vlHWk6Pi1!uctMR#hiL׈Nveu:(QRU#@M XCf׋ Đ:w))@}s7+׃TP2#kתipD q` #owD{}_l ?p@}LnRrPͶ,2Ì 'v|hˏe>%Q5ة- ^Sj:"PRi)dsq9`pWק\"t] $[)3+iN[$,3F~1~a^늚6} ɗ8 sҗc̅Y%G0BڶyCn-Qlрď1R[!L иRs"79^?Vdk@jL@At%!ې`S V aBa8/3Y?ћ>rexz@!TQ2 AYz _AfwD(Ӓ[Nw˙}/Ֆ[ǎĶ 8PIzwd틙ʹZ: V^~%(c5%w_ nzC l!!xLB#AA_G؅,>JI*M T\."O; FL?Z>yI[Qگoggsyuc2jEW QD PGgY"fgTbY( {AhTRD&NuW Q7_5N)' ~rS5s}o )F͘]CQ:{q`àO{U&, z ]ua|_3chEUHF0BF羅) M Co*v+CE2 2Oe迡  یC.k y&)#9!,YUJl )ĥ909+eO^qvbGc:#Ц@b ٢*51xpغT'@ gx|hC]x9~ĨSUaca𣴹uq|jM^թjGΞ U<6j+j(iK ۂk(beM$Q`p:=u:"6Oh5;tJZ.nUM 5dB>su@(`qY c ^EEq$+J  xVnj.%Xc I<*H@Ů&TO4vDqմ,375u $p]oYrVP9.rtzwL2xI߱Wu9WO֖<c|.ilhza>FuÀn,\9U\ m Yz ÷8sJ@:3QIګK9ПkN~ӯӷ&aGi*m%;9m*7^ʁvE?!%#6=L?rcЍ2SMrرU^E$kB YǞ]DYÓ/WߕZ uZ:aA F{OCl>>C Ac-mm}`^v >I9FSDBet:I78#YHRjmZ (H}Yj$d͢&7nGcؿT V1 /ʽP# *HsnbW&2i)|S0G1F0t ˤg$X#ls2"?n8f‘.>˜/ }j|Ot Ĥs\ \SƷrKF+0vM\\4Ml-1ߌ&Z++^pQyqX/.q&A $cPi.mo86DOLU~TɑE7oOk+Hsm9_wӸ}kSDrŮWXG&m{P9Y7jV֠>uMsFN.ڭھ^}-5MAoĸSWmP`h\ +RL}SXZWfѯ~E.&qA0gљC*Za}Ӧ9,_j1RcP9[מƗ Bp,#;pY ^_n Fl/MT_yFlPBT;85 Kb^aVKo}.)pl٢ KK&7q) njzDeZ%L sEf5cZA-JNܰvpN&R;;.=TۘO7r9BM器{4uX&g%3#=Zu~u!{8N _ZAOl٫8 ]4KĔ 1(3`ߤEh IN90/*N1T.ei } ], #;.E/$ .R8S4b!X͜&c웤(-YRAcBc=3(PV-w/jTR^`shETB CWQ(gvr&qSR I:&\L|l 䒴(>Vл%t$+ǻ<9mf-j%H Eg\9 iL17Nѥ]UC:.bF|f?o5vCTZAQ3<+JŜr]#Ѡ"wC 6Hs8·Dj_o`Np8v. +M9  NCpуeT[LD|Ɋ EpS%4n>ä dPT.yէ62S`2}~w?YұE_c*"ub( sPX`xrzV bҎʡΞDX]r&ALQ";B|fM4w,.<';2|NrL^m1?/&'7Ť)~١Ԛ̇ :)1~+ڒdFuGde̪J9Asϛ-NS8DWEԓ1ݨIfB$A}gZL^=s&F/tn~yQ@R<+Mk)Nj6B/ZfFãGt@+/ZK/u%* ^N3r{4; #텾y&=gІQIیT_(d,'8Bf`FjLn~1咐 {Eؓ`F[$g&ba?@\6P&X*ftxdEz=Qg=U>|GR@ޫY&Tm fjʩJ`X3 a* Ëtdf۠EUh$T}7iݖ0ںѱVgb@=>,^Gh HA@ ݆IsaVeē&}J1La%rؾ1 yEyRgXݳ F$/uV.@eTA| 'k2qI卥3pčn58؆DiYmZ'KMh>_ "AǨa 务 O飧Q䄑1LRMTJ/d"h¬Ei+Rlr&&]B3Ѱ&j:vd`A'3:&G)?,uce-1z yzt8^Zi%_c9-R\Iz0V Yq󠥏G* Cw3 /PКICN OTAAp9#!jz`5lLx+ڎ hLd4lU3% gr- m:!̥5.$i kGTuG/m4 ^ ɣx GH 8wq]ѧ3K.وa6kpJo:48.稊V.]GaWͯ+yJe:R٤+; j(l %'] /[^wDve=Dǽ/a8sJyx[.SX娑OJGI,ϻ1ґ&pt:&vJ6vhGvԇvd[vvS;~V;* jѻNWqc~`Fu.)=w\?7G7RΣ?N˵ױTA8ǍBS;'o5n{8bυK@]v$(L6dz̛x5'.vGΰ~YQFcӣF&\x7AF2k؞ (7gNR;aF**N6'[x~lJctpBϯN]Z/+9-XK`x|\MV 7(uB  @X5Prt(Kp08ʚ̷e2H=y#OH g*mӜWąi*r:; n܌Q2)tCw&ܵ咤d>7& h=XtmTt'`&y:D,dA3s TkLB} Wf$AX&y@ȾIWEå; ~i >OSkvf@-t F( |%@Ec<&:QUEQ+kZD'ƨ`}Lo10 D]#Ѩv0ɐJңGm 0QRx* ^P ߟ^UQޅe%Ҟpa]gΥp?v27#iX'c{:m㗫EDr ]-i42Ul <>ŧ@[x6(բժxV_Hm,^2)4NǡYpDynuUޅ( s9$Wf$C/Nή‡1Tܽ?F/knQЭ(4k6LԋbN$z(Tc\\f~^쵼w?kk ֓_zmWn:~Mz^zk`2}@ :Or\[ #ƏFY{rF0ƥm|d7T1}MG>˃yw6~/'۷<}|K7z{>}Nz_IzoiMt'纬[35V: h5թret;)~!;o$2sPh}bH1A+[c#i7ՒKî BRfo3cJRH~}䦮:c`&^aC{jF+?lR햰zBP`CːyWxID +1‡hrqQ/}߇#9`-gm- c5ֺ*n{xGیfoTka}UyUף5i%5^p` f+BqLWaxX)b1AUVˢ(8X T(yݞ!c:Z×p=XWKP P-ҷXR :KDLV׮J`AXj2/EQ)}+|-M՛q:?"A;BPw&QFoU}(!"Ƌ&*BmV5kG A(+75-FfncS0l)dAYBmA sz-b..x#1GDcծ8W-ƞ:82&R N^$ W5.Ui=VW ݛ%:w& 7ukdu!$XʝzA6bj\e-eZ*_i?SayS\3(q0/k_1 tAr8FnRVQQ#Xu=Dlё`SWAv7QQS_VU 0r_!ӪcM7s˘U7H_?IˈŠP+Әa$Mĥp; *ANB gK!haK#Լ[n~"h="a3r\ɘf@(!iA%#ɑ^iFyRpH bSC 2U|tDgĔ;.Kzvʲ#v$Se @rmOgqLB# {F; ;YzBzۃ1ApZ/MV ֱўNܗA~B}%dW wnY@1< PSh4%eOl"gݛHȣL;9Τ.uFUՅ:p̄m\y2?a&aH"*mȳsCV*́:mK6 wEQiP&'͉q쮟 ,F䑨t >w Nn5Ibӑ~3cj #9DN9jQ9K9uZiZzє"T cŰc#SRXsn5n*/%#e 3DNFo[ϗ"&E,C>fQ|jP꨷k%K 5l& Є, ٤qAaB̓C smȜ?mEUG:_xCmW瓚rxd'ݽn7ŜWGDR >jFLS"y<In|qj޺ߺ6Z(x]xȚV+] Ahs{`$bu٩YVO6S*m>F< \‚t\n;y W܋!v_^J2b\otlFהǼCUNF!CȺopڰeF@M h(L:S$5c署),1u'3PI9eTͥnj^Y_zi}5~%t nrr:*)3 M\ʷ~fL0.6 ^#Mڼ!A(7j 0"e#Kgmrbt ~ ?)ˋBѵcr]%z b>^]MS_shJ-F̠5Ptݩf)ҥs/αNpQ5 PP+43Bbj/-ۨT&U;;̾r|FK\w 5کU`̡ 7čjG%b.0/<F !3Y"d:3],'`z"Uq$yR哰EAlȦH%akYAmjCQXydc%YK'b^Q*)M x϶݋3.Å[Ea L%OmwK`>~#9?UpRLjZ}gSFSϼM9oUŲ6vK:`&-xܪmTP!,&:Ѷ.mL['T6Y%jdf V A3' d%~;Xq(jO+~,j`)nMֆƗ'FS!<ω^a>=R(- 2"\Hض-q1Q}d*޵:4(R`b.ɋeޯ6o ɿ?ypuFP8ȪFyʬrY=*Sl,Z@঎A`;䱥nDC Y9Cx)4*AHH$ϷK:N KzAΤAU^gQIa(A:'PKu'ͭm?fuj)p87xIr~</*Lba+ANP>ǫ+beLmKZ29u M״;T3h/)m-Eƚyl!Î7h1UɘY84ATyxeX\v NSE,695ϗƿ HX^lC!-d6%i$ wŮA)}QWEHqw=i7ҳq094e,'츜W r7E.lW͎cD:o'9լU2[v-Nc_]٬V2au L82iJ:8$$ >ur^(v9x.vTX:3U[5Y){*26pж-Iˡ V{s,(7*=VY#*kOj=K|[זl);ZB|fġ%F#Hs7ht`,#Ge~,nА]zf9ߺ #'74VRץR'.^%$[=UQRk&h*di&M 5zo8t(:?["bP4n|dX16cT(,]\|+)u+[mt f{Z;OP@j0nv4ڰ͑"^Voqjg8ߖi E"#{Y7(! a}qT}DKRuud9K :Jw'Hp: rdWΝA<{jKѼEJ/zG0#(U*+ukWE6qg0`v4bw̄04x']=7H>K@twG(ChQU+#QOʛ6|cq.&Hef2f_M~,LWas[OdFeb>TQS>g8-z* 9HwO=.wX{zW1oFP*FF2e*#t#عYmQmq\ePcnx 2y g$X d Y);z$F/+Gy$YndYICEڮikndbxSG; jKNk<Y 3v0fdBaEBd;/>,T!fauhH?Ɇcʴ]Ѝ2)QkHQʴBɍ a'1q '9L}Vڎ2֞^8ʙAl[MT Ẽ*^:Y B/ tpmCdiea"5TTGw _bOYJDʩGU%I% /K!dmks?ys%}=$BE5su}dV vߤFT h{`_:ڙ [8ꀃmu'gB mT ҄(QOP]ᥚT!?h:pz:}$)@<ŗТ NVW7(z$W("@ܦj{;!ykCWKc5DըNGo΍:j5Btfq66HMu󋬌8+d2Q_k% F6YY¥Y6E 7Lԙ^O KÿZ"HwXГ,2,%vnqͽꕴD|l1c_㳣 yċ =*OnHʸ$"Gi/<%z c4Duʕ. XhhP)~F aB}0F|`f(%o gr~=0L2N;mm*@)u _;ۨBvml:D>)q4ݐ:6D[?uazd_{=`Z*{ɱN"dϦZH$gE%=W:Y]r1#? CqP}2wHSao&EyӉSΧIXaFqPj^!M&̍6Jy.hJZ+y)L2Ē7-h=h-)2 cD4Cw==}F e֔{tϳD$.l&d ly|<8l`C ɊcgkVZcvȵt{R@>d[dD Χ)l؏+<#TNj(T1cteӫ9[wn]>wL6F)YjAZm0Qu90ŏ&#B vXlօˡduI0_ojODyYӃ h9l3hǙΩ G'FLjozM̊`b[\(FSx[.}Ah'h4uuJOn'.=Ye A=dGt1܋ [+K񒤶El X XcS.~1?6Ut̄QE ЙH#T/KhX݃,C=W y^ te~dDjMXɋGU>:qOPuӺW2,{[i1=̗3^`CXvULir DW\yHtLtXWͣ6zVjpYܬCaWTDM*'z h_@@''\PG&Q H3e `m`(8Hg\OEqR@P6 n؜܄Ufl$-eT\>(5l3 H,,zu;GNweS"yw\}pWR'?T$jk_KK(nGl[eg P*1@Ǵ@`gJX?xEAeau7"`u 2_"6b*!#<4;nM}z<3=1u|ߥ>sA/ *%ȿJǣP0ԲAdH Qm4p% XHrtBrd,7Bj`ĂmT d0!YIme8svcT6.O5iR@6V<{L)BU6X,ly(R(C1kE"ޝjƍ|ω[T(Z+JӞ/Ա ~Fk_ /38~cQ -O>4QaqTY9i<'2ڙ('ؒ Fx?TaY4ξZG= I3㭟$y7u$@UqWM#5YQcaqL~ alk50rp eI~MC_ ;c)<)%(YZjeء& SLz/0*ˎ= Wp7S88}ZE?Qe3/% llUy$s*F \QDpie]!A`=Aq){?Tc!Q3!dj~>Lc/)Ѷș)3+GOsĜ^fĻ}C_x;sj i(jCedۥJHH ٿ_68zx1?8`kx-#]֦ lATYUzjm4RґUAՓ$];b A0bEԺoJ۵=\[JJ!@'ى$꧞(I3Rd06I=7`8.dKVmduL$y.\Mr{0&O("r'YLx$6 9@ @ ž: N ܐQ7h* 4 %i${1M 02y lh}\㘔/g_7Q$iIάI?NCz"Uc5WVàNM1(j^#."S㵔@[X^keH0Ke5[Jċ`WAORic1mn2w(Fʃ'0xpLC@n4bX.C#UDrߩ%eSy'a AɈQSIԲ!HS[~}kpcs^bt>$!E9| Z PVD}| :MUY%bc 6(x Ŭ#3Q9iHU&QH%i(25qH>ضlx6/ JF$^OB@Ş"qV̗⿓ʘ*eau[`M8Y0H^~?e ZK7 z볷*(lIAF_ "J6yTl¿s~Lo؆-yҙsouedoui;]bB( !&5_K( WpulTj!M8/f>ɏkH9RwUA`AʳA*иL[HQU a"ƹ,'F\OmUM0n*Ukխ'|K6A˿F0OH cH3R2OL6\$CÓ^vDp**$)zPJ^RS:BY.UGցEnjkXdѥTZY"j*~pww.TL 1,Jھ+CճKm35x^(e8VbS xJ7iu X{2}/*يdKĉo+_2r@Q1 Ϻc3^xaxS`,^â\ z*%;^7WaHkl#III[݌:Mpz+M^L"^ЩDv3uEOlLUOT2)@YoB,ǐgg |q/LN]-|fԹ]XgS#R(*ؗb[$6&f3m}LfFx~ςJ:w*ym3p\6C;<_֋y^b*`BدvlR* vk("͛cS^rA\nTE+g+gNz4ykKn4\+ b6dUfX>ڌDbùq F'3ںxϫxnVb6^ d+DY5ypp07^1Dzlb4'eXݵfx(vF'-_O@9V !#~V&̨=pJ#ʱyL`[ŋD(JB/h2sW5&:4ք߁/BU|Àmƚ7HZQ=SYWmʮބ5۬|u9ĭj[}Q~5Ȣ[wUvUo}`;裾X@s &i"oZ9.[aGXww9;dbYX JdR2koB\Ɉdj«m1FhH_ŗ/uBpC;\݅ v@œ^4bHԉRTEyj5yU:~7V[TwFPQ-@wep;V&Hh,B6 jlQYE^2/#/a ޲X%Uw@)sXoA9fj7G4 RJ]9hCp;>X.#`MguQIF# ^_ڬV+DWVnJLPcA:y9-E8w@>vpy/&fJsG!<.:|ELJ@uDo>Xݜ/fG]Qw7U%Ogg@_OǠ@aomN"P[(eD3e:t&&#(fLmje}"G}ʡz@6؆(kW4!#cYf ơ eűZXosz086^y C<[BuxV| JjQMbF~$-4XےrHi},&S#3A[!?_ķ|[goJp@PY$ɚP(EdkY(+\Q]ɬcȢs&FY̗1x@>O tNG`o4P~᳑(T奡;lk)5MRe~0qQNΨT.ޯJ d-d&Oę Q@m\NvlEwj'Yn8_B"ovsaM~|+Bk,2ekZ\3γuCjpi,Yո<0v.=:Qq4`(reOd>e 2*p.pdS;q]7U} !hF;Hm;`D! @YBv&]b_",y.7ܱlE+AX㷶M.3】 GYb-ꮪ% y qLZgM3 ~ xȺ3 q^!$/jGCu/i:AyK%\OF?֏ bW^fA0_ӂ'Q=qg K,JwQ4S.oU ^JrǒDH AdN72ҽԶ4!#f6 )N鮆!@B&NI}2< $7 f<fskjOkK*+n ^ 4r o;d: h0`Iא4>evLMD`V޲ig#͎`5Fn K5itܼKȭ2vWu$:!l#}1'-@QqT8#zOF \jYh=`QX=CGWa&"9"v3Ǿ屵oJP㓑4RvB&|$1^1?$^Gby0("Ynix:ȥz&Gm\|{;2e+rx%aldGʼăs/`b@Y` _ -2 E?U-tO B4%tA82zPQ<3j4J&'x9yk{zfo1"(P;rR!O6MgeOjjFZ ޭjJCz,BԄBŒDYg{ eKꇈf?2s ,VPojڔg*e U- rb.`?IL`|@UW/7I']2N#SY*"Fubeν^I/8Hb?^yZ^EjOnO|,u$>S\>7@^LaKd0 "<4//M u;z>b~U_. Gv\K5HTEV6I.,RܼZHYdAqdP)\HZ5 Tv NXH}P{\VeiӮI.Em6I\RTh-Ӫ d _Z0X' 5ڍ&:i eۘ,fU]Q 1Jrex'ݕnN|td XCقD6+Oc kb,v&rM'Up(#f4U2صtvwKS(L^ܖ+d'etU͑{eW WHuk#Ү58)Jƨ#ֺ<.GqZ" ba`gxxVGf!:M!Fᶲ:U/{ ˪omׁ^UDGl|5ȯD SJ[wѿP|9 cD)UĂ>\I&!U#s^FdY 0_CMFltHpW1+Qm%ceƗYcE5q*R܄%UTA ;.Qy(]kg8{3PZaĦN(DI7xS"Q @Z`ThfhS[rR8KSH0MōݑV Q Mx~,\B# eN^,`:៭q/[:uXw MLC|YFU47/^Gsݓnj"H ECzaS唧w3򳷃^آvgv2O ve͊W^+G=[gkV~{|8XU;@=+UIR*e^k΢[3ҪzM0'k§f"QQLMN ʬn. ϊwo8u,8=Elovxm5\4i@Mf+q_8h{ǐ*F6b]٤(3r x4SLj05⃾PS >Dtޱrr<f!AP#K&>sP>,ܬQ6.2PmurfOea5+684OH;5L㩬[^y呌[70oV^z::ovjj\cAj-p."Bn7jj hj Q9I 4ycky}{355:9ؤR8mk2[+7 ,jN>"͎XzF[y^Dh6C#dF i+8q{)fjbM;6^vr6Q#:W: d*>48ϚwEa+xa6 o},hg5ReI3]d6&b#%6v<Tdax<[m%;tf33BG^G1$Lȯ>eJxLEox҆{:BIMT2c9Y;+ǐ_9⧈4z~z_DMT>et66j`GGro^PWX*V>o<_J_J)EqT }J)V|`CPx.yn)ըz+X tkQ_\/DHIŊ+\?GmL9 petq@lcLD|CY;ƹe6}qW4U1bl^ܯѣ'V[%aL_v_`Da\c-mFjwgĻRZ&Y6zx7~MȊ8݉@ԮdȗpclvU9 X!)!ekޅoklac̼X ]kJTTF-V'hʡ6>~h\F,mlTڄ/e YݵE9ugPW f:wT (u*S4o0FWwKXi4S̘YZWeQr=)Ӻ擳D̉euL\SI6a6}Ƞ\|jBq['9\Yv4_V*), ~kV(ԯh: S5U jNhoF(_oՎN"nְ[^_l"~y P L%f-x+B5;Vks OkyjqhU E)zeg!p%Hczh1؀a,-"rJSfuVǃN\9IcJ MF*l-M[d=λ򰣎4Er !;dg.Elu|"DPX:% 5%_% j@;A&Lϐ$MG& mz;FBO |KJbI@ᲾsX=OOtsy8"ΝR u‘u##\b4BZې#NݲyDg]:\cNzATZ19GY|}47ŭP/ѪaIp 6`~Ad}BˠFV̹ ݻވw \gJdqU! &eV#UT)= ˢ{1#9NY/Lp:\)- 5ֹI3 F#Ym ܨ7'EG`UjR19]=kDoĹ ; u/.cvœ1J裌OPT90s IA1*p Y\^SwUGΒ@Y浥A֪qXNY07a&  C\o<աD0J#R9z%M5FƈM*NTB)bcU*wSYHenR!bV+>k1e8vf2]8e~-?.4ޤC]13 E)Yw]ÉҐLu4F+{kVE8nasSk6 ~`>3c,ƮsԩRkuZBdvkiӽ{fwkw {@ugpu KU7M"I_͊q&sNNo6"C*<8K{Z:I+Qk֕EC!hh-F(!n~jOMI9 @ENvjhBcT=4xkGc. ~áR!Mܿ7qw^[el`9dTIS :}Ԓ$\gx36qr }}ϸ>|*)]dT>}Qc Gӯ7VEpt9e){_OSbεy.<[͘ӚJKRMqQ-byvߟ!ll2?/3oH5g O߬@*_cᛵ`9R3=|Q+pf}1W4`}p`6jj$U IS\-ޭIh'z%PJRd/+XI#`oElyVwܢ/; D;T}/]d vW sjA}8 //(%QЙK]2wpYC:کZQ r]"dQQ5kԋiP}jZV, h %}ڌ>%و~Av#ӥ31ՠ5d1!lR>M;(f VKbs,6k(c%ԯ! ?aR ". g)y[*ίo{KPϋNS(C}$д2EݮW?̬9Ȩ*6N0þ"` G+`y ) o|8].1A#,Ko٫vc*/D9>Dc7øȳ\ l2e^g#7X#(3>*%Cn!ZBfhy\P0v+FY R~73_."%g2ZXGMe%cQh"lKVJ~K^)ѐ Gj,I y| 4ޖ3auMFû&!n=flhDFܣwK=ۑvvo!j_DJl!$̗.,+5p0[ٙgWgOqCjl<  c;՘Ubҫ-dq/rǺ,<H-GUKݠ!&@7l!f,?<8HKI?cIe\_+:I8ԭߝy2DE-ep̨华h#ڹ qbg[4!x+h`bG9x`tmK&Kjy!13M0(٣a2Y2{"0ۣ$EJ)],aZ{\z; T'-䃾R* 5{K/Uyx+X5q C~6JJ$pPLq#S+Rpɼ l,vd5kDr  \}9AڤNq Da_ˍs7ǩGU-ɒ3cMS\ZD}^B.*Qcq3;2QmWDM :(^hvWg.k ӘG׃(ڷ-_d_D55~!3>lc'߻ 4 0kP Yn,T&#'g3RtM9ZAIq Mc*^^_XS\ٝAxxf&C8n;^>Khl7CٖNC$nѶ{o<׷'^)Aw$KtV䩯;_ˆ`B`do:@A#8v@vTwJC ~dg{B{L|o-;!KnnҲYKWiKĎF 1xWcY˃<wAB7 `<=΅3kMjGީw(d7p>@mhRz( G)|cdHUb*LGqe1DB[m&Bk2뚮"P{ 3hwqSJM0/ >50x쌆@KMd4~(}4(C؂m$g0JƢkV3,vV$oS fupZNzWK:c3gBI<~5F0^J4]j ,s MJKC>uWz%wXRX1 3k ,GdEXrv&ىbS"MtE)oy#ig UQ`.x籰md X 6.9vŜ+ pF;Ao>B2㛈68ɐ`oFf!Y z<UK/^0Ugnh_r~kG)XF2APkcS* SJN֣OhHMܒ&%.:nAJWUjh&+DlR*BZ]uIW_OMWuG) \p(8~SkgF"0zIr.ȵ*bʎe|NY/<ՕnW}fO 6dp'e&i3v-ߛ6&qRac&#(s Lm@E{]L>&k͔ @KЌ 磝}PT%nWr{8xCK~:Q񤚫nx:cvC=P/起%P[YPբ&Q:ac8(QB4;| ū;VtFj5f )+,vbu!rG(yysu7" L9?1蝺mh Ye N{s˝6 `p# #.M7!.;a67H!.k'`XU˄S?'d.a@.j7[DL%~{q#z6,ƙJ'q`&&W0Rr8b .U-9PԕGFcM@į `<_tkp]@)8xX[~̢UVh_HMvTBCC@8y C$IQptHvޝAӮkɮp!uQ­~JNYy_)g=qӔx@ ӓ˦ p2Jd3(,uYgr X#8ɒy:.-іG2;Qz_(e\$P:NKEp#db+|$KXBq"Bu/70D7h_2&I]2z9xK\9Jz--`tşp|줱k0k" xKÓɞ`ijdzm\l[\BsROP>[Kưv34+(e7{~M|'B Pt.KdmAJxIfB5] E'3"[d'ѲGλcurQ"l)!l * 6㻢A{@d^?{Ń)~ 쏁16:"`eʩE'XTh왵 RGLub}x VF68%+¢ Ֆ/*2[1@j&S bOɋd ޷` q}iT9 T ":N~M NfpJ\KRD#WĆdm-g:HohX|1~E Xs+VuмP?S~p'WaMs|=Qabkmqx}vt0.q%zTShni&SZ)ö\U1)zQ\MD9֌ҷ3])'8$yiu0l{酯8fPvx~S@Wf"`8-ב4}HqY=53q?cS&,,={AխG؊F,∘BoAc4@6ދ==RY9EJkZ;vjcS&]YCf;;ŧLJEphMGYWȑA^ĽwpF6敍Ti֔\zv-uFdTJca2 )p Dd7aPI)[!cyQb h%Nޫ,CylSj'Tɤ>QEhSgA- Sૻ,kTioL84JR A̯cnltZ6pnܲԇfv{6iA$J6x6 s(6h9:pn#aH re֌UV|T7q),W^_VtᮑX7k[^g'T.*TwöfnImg%R]"\7`QqAfgK@)ƭ*q 0(; BunOcơżG\+nt܊\!̗̾Gu:V|g_W~,Z12TPMu g+eMUqW3NL]Ultdנw  w 8TɾȢ(tW_lZ^QuƓ\?k 9kSKw2hjBжHpW @"\§8 |qzGrdT yA|Gc%p:fJ+`Llr:> {bAH/Hp$5:ؑAaT7%p%  eDa=DZ2Y4\"(uq1yyXmB9J }| A$H; P-7 L5uI|j?L& + I3ѢseJ/59IuYN(,D`!܎C(نƬ.ոR/VƤiv{|Sb-NRq06\j`7f@[veGVOvP{H$Qd67`!Ûꏬ벺1-`|ப*) W U+Ap ԝFʼR g}J:*yMN fjVՏKsj'xVtW(a#kfUADQ~t)vN "ۡՏ!doWVc(OB!&Mhe,8 ;hFa״KA*5+o(PyFau r|FL@[6s  ^oR"P{>S8٩<#m @*LE㑦֬YybZWLN*8E?ĩXs#>כͭ^Q2}#_os Axfj;PD]Jt*L/FgZ[0NiQ(Ź"i?R6S5.p8<ڀ $j73\%A_~MQQE9-zDZ : PW1]p&ѷBRAkpW<gNBCj5%L%ƱqcDq2o=W B ֬~Ι d.|x-gUgD'(ǀzzS赺ovXƚs-co:oa䬷ƾM:7jqꮟo_T%w}uG8*|@b ·v>{iFe6 {6ὒz&OSWF"@y>v qcp}EaUG!/k#ʁ'fQ_ nد0,7.'R;7B8>ӈg@p5 TV]Ėm<VjRs$7^[璖YBo'&=2 m!vŮf g =VݨIBYN/4Ȓ dqEXRGtLfQu k ]# at`æC[MX TV%w<.T'־[v8A66Yq{@$Tf?vпыѦ1|1HDH0gZ#:2g5GP4'Z{*tH0^ # IЁEӑ1#܎Mp`t;L7;Ov_um@#83>ntXKc%HWBzv_ 7]1|{ĵ"7Im{AaLjӈ?9Q"2ۨGfߞZZ^r+BUqen>*ɎaYw6@mgl* <&ZMڱNSEHXj̫n WߍnU!ѭPnF+ rDקQfNفp(,o%ef. P?'Gf6D1T lqGlbc,%ʙ vaM6]{䅆Cu^/ʾ!A?OsZ^ʔq5 z@4VQ뢋(54ZA|#;QonWhZpc ٍ3ޔhx'a/Oي JR,ی6cؿ܌UAOa-a:h랾Bk>TkX ~ڶȓ~޶X"Gޟ~6Mr ,A83Vـ 5k kJ_l~& T$nr @?}r1뾤;r(1>l)܌M}dyPԥ(d")$}un>$hJ~mi|5=OFBG"%2ү w9|ĻO}K?TXYљqaU?z!$ w4}C;ZH`|`2~45fB.ӫ}kzLCăy@7W+Xc@iR/unbȓ`ސ^AJy47RVdk*1+֪$= ReVt r$6]`T4$ ‚@* gZ;@/ O/ Gpq%Z zKC^J=oe'oQbmrį˜gsf7̏X|,`Z"kO q~w0=wR(3z9T*ZvJ M춞# \&gDprkYo~Qy3 2ٟFH&g,AXzb!>{d{#o)R7 )\k8t4S9 p+fFlpaf7jt#GE$2~Ycf4N!ڝ[M`LzH@L>]<@{փ?mݕ?_Q5Ri'E.TiG-y2ܥB Zg 4n)v>֩ߞcMf{)`|!Q/̙WW0#UCB|5iI?O>z^EQFciSc=[(6F(A*䬡w }}8*Jd8P62Ep,`.$'VL蓇o*(w+f#'O˴*GV'**(KS>;\Qj3gbxc=2ψKT+dގon*Ew0U FF}wR$D;֣\+d Y62^{Vx&_,#@3s>~(DSro7Bc, 7<;CӳjЧߓ9Ė9η`r­'m\ S:JI;e3(?^!LK!.c^)-ao|q&(VJL[ ZI& u=nkB5ofɔjM^\<Ҩ&#aTYguA"΅Bd=ُav5l"fu\3 +ds9 5J VA1mnd7.:@ e9.Dъ1u|ut(lS:L<+lBkBc{&yCP|=$@o%$1bV7a&o</y)Q!SΪ;A9w0A$Yed\IScmN11Xa|̓ұ]~hHrE֪`REbH>eP[˫ih[&y^ί ;G_z1T7b~ dκB_N4~BW3j }]30<&T]tUm)JiG(|?)j|Jb3tKe(WZ~/ l+zI٘ LTT܎,:Py{6Kf1qd7zt* [vlq9!б<:-S_cS R $õ;E*" 5$)NgHo\\1R B\莐HjL2nrGEٙ-M\qa:]\\x]Wt"His.}zmd;֧v6rڤg[-Izdu[XޓU Cy)r ^Vƚ0ʱD&+E5 E>!5h ⅜V*bofi0k(cB YKfZ}3[q#\``b}cG%36<\hK CƱ?TqCZ JC?#Ҵ)5MKըE/&4RPT 1 bR4qli hKдbO2yxMcn:Kg'T\O% ny(_==׻Vo$s _@d}mPU`dy/+n \MbW5ZJ]3WUAi6L|PpJ?\l`׋#ݘbG"2ٴ9]ו.덯5@BdټJ*<V;+T]nEZ0MwI;z)hƇ}=}YPk%F!U̺$\x*j%m)pc lx`kӍq a7b<\߻YoA=iBxxz -ب;A*雕P;:ǚSR`Vк|Rع㔃)Xtj)xI-c@ăGX__n|PR#/2.B ʹMa?4 k5\⟰P"Z;E;ѺgEѤ_ ]]aaZ k\3, )UsEu)֗4,DP~Az 'G/$'@~aJb 8.WP1G "Dz-{wˋ$&^jy50{Y$kAGr<.R8UP-jq2lvQOoSzEU;b#-qܶ<N1QX1@4N}QŸ,;XõbE[KqĶ(fuRT!% *HcP]\XV$5+͢%a-K8>t.5K&R lFgZuv&|K簂Լ-뛨@:[)!7f?}ߵZ^WOdB+\_`^$/|}L?^3>gtH;/uűuƱFa+R]Ċ.7F%,;p6-:':,P#EnOaa7*|PHS'$͗۠:;(&2(X vCެ>mA<6ҧ'kVW! ~0՟NWkɰסY-:S7m;A }B+gѷuhTxƒ̬$$F'}|R5<6c{O*Cהs٩>ͨiW%1Ewя\8ً0EP“$C@C}r(>' d{G&[wj).e,$5=ͫlvtX*"|fℾ/+XZgr$%8ЄW45 6!JGA`xFY'|9u6kMûI\*ذagc#礊nqF*qKحNobsj,C@uW^i[vk`XcS_>F.0(AL4S /TZǮ,]$-Q|HR$LmW".\!2G 'xNjAZi{nuBZ`kws8/3E+$)ytxc3ud0kij{ Ճ@,d hf='`;<-ƈ% l#Sָ ԋSPQk'`e# +($P 5]FƱ/>m鑀AoϢ i* !^C'RKxĜ.1;\+OVIi?YSXTꑦ:DkGԄlmlo 7u42)54kIS r}Yq jN] /u$k1 ]^)uiiK|S7 _U! % =}Sh@sJs[EVdb Zo)RYUXG+ڔ7*s*PĐ{) ɠ ׆/RahoatpiYF3-ұf+|n|jK␚vpeHÄlr}LG@aZOa _9;:s)j؜zkj(v&(rTlB EwLiD!6)AT$M"7:ÓO<7ʚ=xXDymy\u!D8VSfl#?Ȋ}QjFF)`:HDWRmuG5^d^.b,iOʳ\$RW"nUMzzt@%.KFmSQS76u*BqhkR;wFIm OeisϤ7Q/Xεvl65j x̙tĹ8D^ݓnƼ]d꺬- x0WHJum2^$u A:\,Ak+H! )^)[;٩g;dh_!s(S>cE"UFìhF2PLJw>|\id1a|gxsLWZ 3ݨXBH%RTUsvnY~m~ӆ2{Ӓ"*pZ+@pѦ}1WvڊݫD = iB, x}v;/i^D@)4/H6GUV8hӢ%:%Z(88^e ]Ɖ{hŨ8ÞsT,j@Bn)5+ .Wحw!fku3g+N`_ N!!dd]CJ@dzlVgÜK:S}h ֖FrcԨD_9m SZMdt)1=i^,Nxh5Z;Xqc'2_N1']sE: hLp]6zk5XS^tlV^JŃFSRƨv>ox=}YMp1w 'V\'OkYߞ,J7NqRL4/Ҍ92q(L;}CE43cn4&j 0hӑ))TZv5L.=V'Ɯм?>sϸCBoeZq~NHsoPU^DJ@FRFsjy o )s/{x yJb:1XaκާlMQt--dNnMJ|sDN " _hn*ϋUO|#Ϥ@ȯ^4T4Q˩{A6Jw59o}1dG_I5AW%!=Y锭m#82p-*(5jGNYר;O2?pHbձU x33bՖ|pl*֯fTq5flL_9m L;$rԤ K`cs_Pd<., 1}x)BLlr'uGS NT{sBAZd.:hE%,DՀFtA$v=FGk;z' 9859 #aۘ<F7p%{fo ipx2o{ũs7 1>CPb2C|AH䞽`pT`^/ʧ꫐x].Ot:۹YAxB`o fU5Gb^jn~t5:]j(!FEJd6jOQC3/Nqtg(yl^PC/FG`Yk`f|B_/.8Z.5ѥR-)LƑg(Esk@;FWKN UЕS1#}_5U:|%n=PX`vOw]q 1;1JW_D|^" .::)^H+?xS4?WopHFX6E܁c0Z0u$4nXhyGaKͯuV>+!czbK2l١xV>xbLzW[x8XKU:Cc7G2Vb˜ a/[6"D .xThOry^b|>`e/!(d?ʿ1 ^&iCwjh3on7(h1CAuӬͫ}Kst@o-|8቞d~oFEuɻ(q?:3j}Qei H,U!mžbirX KTlROMBzE >| ( =YNWѯ *%Q>%|k' 0RK2Tv ]*'&m Ɍ kP0Y:0[֜!%ODsSC'ꋈEM/~4j0ѧT,fbHaHu%fQJ+ (V+_*2cdrvI:MZLHhWƝU,b6~!bvi YP^jó ކg;b099MQ G>lH').N͓EM1tMO8/C,v?w`b0="u mE 7s99X6ZCDesk정ڛ1DޘSphxa1(7 :F3Q٧uR$cX`~y ؎7IG2zx %1!~?7"kc~9sO]А~* sw.arR&cښo"P,6B1Y>n0EDZ3aFP%c++a8hq NS%ynblfZč'#'U[1<8FE:*>k}O*w˛8 )QiL'^e \0o0J@J1!(j>]hr/ߩ1 1?+3j@qHl`7?-X.6]WbC]c(:J-Z{ұUM=[ДcHnR4jd#CnQ`Yf1X2;eJpfƖ<yďy$C=]:}6| IQӘ}jY5؄‚v܁QR^\pn=` 1R9|adbtdU&AVGTqhp$BD'rzz1TAFCE.4oVFztǺX>`D(079̶)Y{B!j98SY.ݘqg_'5)K$,Ԯ@4r'㬌=аB0Y-Q}N>Lb8" hZ |?jꚒM,icR41f~jDp&'M z$q֯x7A=4A CmצR#l} SP਱xxAy?܃wi#jeu[kX 9G*s K`,$nWi|}`Ewjl7@ Ekt;IOj^I}JdjH=U;HW_$Jj$90|Z3γ&2SHߐɀ;*; 4}Q@Zs:L4r+/X ~BSE#b<b!&V"mD_ѷ hm|(Żl3="0v~%xF\Y8j9:{t?GAӞqnw6Nf_j8k< ::jdQy[;c1 znG彌mV"_HQQoZ;kTH؀d.z0l&+3Trcjb#J ; gvۭ.H֋k֖@ @X-+ d^!;pts9o1eLSr (:d52%BQ"~㜯p]z7;bJjxwE4Ǥb-=#k\ y87ך(B+CP+гKRLJ>ȱGiG@8UfZ:q$e)?>q;x\L1e G($s\OfpxMOkoVȊ[0UO0PeXPSdLAx#f=xui² x$gnCS!VJ2`cչUPoh)$\C*f{~̹R?ܙѣhd]#X08ܿՖ~%cɧ@sqƞ)*xiHN… lMү08YX[G½{1u_s^/W sSSyMc|L*rcgut>帤%TKry5G%%x(i.bs-5g+Nqi$*uw6n_Y*Qsk@Ehj%A kn(sPmœvO| &/P9mG J bSBY۹ n,{S>_hd0u$1&kjjaHYN֌-EM1_ԠTwgMw߳EUJl%A0质TJT]:t*"G?=cGLA)iUDُV[Qoo+_ ncњ̎:#姶l/;v>bWq LTxOA}l1דA(3"wf[C$VI(6=.dTlĦUU}qse .1*8'i3@yJJO7%ˢ[7y"b(AvN x<;:%r?b_(MtޔnF/F'Бz_-IJlS$g6os@RRuOv"0X@lj^9esupխAV M۠^A\x0n3R [3UBJ(k9J.œb$$@ S8$EZA YƑ6M-:/2/uFe@!\&$-d5v_)ZBDP ׷jb4ONbLLHǸ(X";z+:8k#qj\9oD¢ے0N:d 7 #_B73D?<5:wSHr&EJxJxF"6T8/@vH~K[KB/9Zs]-kN6o.Ӿ-ͷ{K;3Xa*V).@"Ʉד S?a.NY1+zR=ylX8N*IØYC ҪʊW>YB6v.IL3`vu{buֵ a_;zq({>z~ I,]I\oXHbڷq?#W(XbnL󇻣2c<|@)@()LXKW>\o|."̸܇Rt˖WJˈA'unRWSAߔ C)WUcldGf_"lru۬}$*\!hEѺ1Ws-ԺHA ٞ'Tѕ8Y»,sha,8?R%ۼwo.}ĠǻnV'Sª'f^!%Zz3v!It~iVL̆885L>Sњ6y ]*pP}hAZޕߒ$8|"T$2),%yQrqLi#5p~JDх1XT<"FA)/QzN/}vPndpU0TFF;65;u;u0,'9)H@łTN$_ 9˰/nF௖R[ЇDuY5?G{^} 0=p9IO07سUKscW=9U@S{ KdjOrlr@j$aCxzS?.4獂:D#ӘpRMBXGLPzԋX+3ӧ-Ǟ=GB-ǀBDxsR!#?<*bb/HXtR.R򛩵Q߾7|&KNXH:^q_|F\1Cr}ܦ?PG#s\vF qk>qjQk+KǏhPFKϚڨ Wb"NJ?f A9*"OB"Rzs0m X1(dqNǐJ䩐Y$yZ '4G4^ƁBΝGI}:ʐtU w&c nIr Y΋ݐ.(m$+; V)92(JA˰ԡLeY \f>"/\>.02Ei_lSWF:%p)ziv8ddV'Lm [$fWK~2CƃC$ӈwuϫ `MQC6h`T@lO.}̗oҤ ~ףs9fLIQBJmp,:ԄbW>a?.4獂tkdOc v@iD1֑%fq_WI$7 +ա}y\HeVw{ ;|eFJIH *}y]VgfgvoPb ;u ,:w=uy:,ʤ۟+*:ƞ^\f棗 {%;-?4zQv ]sk!کBv~׎/p^|賌>~GQuڝ@Nےک4y":,ٺ^zReHYX~AJ RM#;󪺤V/$hi`: j Ϊ$&2yöBIdg]DjW.DjLRV[< R5tGBK\*la-͋&J$!)zۘl RF޽ .eTV],6"Vt@Y< Ko 7aciD m " ՆXJDKeԷklρN`Ru,\4-~3!`"& _ g wb sӤ>b~l(giW/ (` $tn6SMk,H0*V%PCsu֥T5-VIInzi 6PkՆV:`NFpy{ ϊ&_jݜcƴT:@K,*.N, t㢷Cc/8~vy)_R:V'-#t-+3mx]]@28?$!G, u~o4݋7Cy5PBg˜'|>m9HT+ 5hlIa>b];W{X!҅?l6c/12bQgסP0h0Bx`K,|"7= "GX+Ts[;@.!hzxCf;EL8?(ҵRE-V5w >F6wJ?-/̻R nԀIS;gM["Q4D3IyP894i AѩTmZ-LSs YVQFM}*~٧jp鮎 N>/(-xcU14l22v2NCscz-Fqbyx jfmedrAeu[/jYfaUCZ01 =C?+Q7ܪlLjk !eHǺ4wc e4].F)c Uri13T6z8Y3CC*:8a@F&T4p[BEg;]Ay22%B_q#vZ~|u.v uYf~M)pyFC2b'r(L"쉫L)&kz١j@R iM8"?ρpVj!.VK `mxƇ|RD1,hnܡ>.k/|Vt~9hf ޺mOV7 p\:q8Lu@_[Cs E'F{¬9oD1+n慅v- ¶ F{|"auhK-g4MnxjŻ:v]>HjkrUvFhiSr+9Wh'ehރ҈Wx4R#<;kQB#]׋'bP,[3E+J_}:+Ծc:GszmBT!݉l_l5ޠ4P,V%,$/^ =|6TAYfeaҊatl@[06e?W[ؠȾLjRĺc%k(uh}EqbFW!yJbeBWrn|F5z1ˇNP_UNf;\޾x{uRutΉu<sjK]WCШx*$T fNl*Fqn L;uSܜN5խxfY[74-6*$dU,rsypFQR^} BYY*qWԪ$CܦڂtSa`9FX&WeQ9CkA]f:} E"4 _鯊`8ȕk 6TZ̕Ht=~[B\ؾ||l7ɏ݃yrpep+& Y621~{mTXr&g'fD5Uvnۆt L|oJ0L!h }+ |̇;ٴ:xKHEt@&Mt5RG7D1)P3M;wJGLPS`Pi[lDRTkK*l4(caC KIA7+ҳp6Ϩ]%һy86qZ(7a+Xzːdһ2 b!I`y*Ee(z—9qsrȕ䷈9ҿgs,S!b7*f56qDqnٕ97$n+3|y_݇|̶#SB¸jƱ#sfyUaaU{_$Onx# _;U r$ݨ+PoۓE+|hޙգ&ڒq+¯1s~N@egnQ]jd6e9yoi Csh|Gf9q7NCc[P>pN բ0./_Q#ȁM7_w}d1V u=64oY3h{7q q[aZvW b$`Pfd/Dc5"5R-q!w @Wgڲ#3\ q3$KstTë,,o}4X8GiMOF6h]kGuhZ2`8Bqn4X iѽ'<q -'oe &NٌEag0`5ŷ'q\|o(bBo}o5^gřǥ†|Q̯,Qb ul.[ rik=n>!sKkW$Xv42g-ۘ\2uJ|`c%JVSH0-b)-TnUؗϵFeR`]mQUM8Ň~vs@pU5K[{ܐ܄~M>}x~B4y0,lzgsq6\NQ]%xZ7"stof݂Q^N롭R=ZWV= lJǽT[RR-ҩ-u~o[k7ͽ&5b&sBfK5RCUnr]-CB) a}}6ȱXL) 54˰Mt F-{hIn[Ҥ&l`h*@Bͧvq)|q6O1+sr(G7)4p>&Cep#X̦-H"?k x:n+"^DQ!@H2XʠPtDz9N8#6s9?ziqQG=(f%"錐a]#T\_mKW!mҪ'L# ڶ)dp{1N;])Ƒx` #&c\(JHC>߂pDFzE-0v*I{ޢ/:&k1A9Bn3Uօ5κp k=7L`GOӻM;8_o9.a ,=1'sp9\ص퐆N|xl!ijy b!Dwg]5Qawtݥ8*QfՈJ*-=b>?$yRQeF\e+|WS~/ծs~Ņvpg:مmꮪ=>%$;c$`T715gx"# G"Uf]: CFv<ԵGtQQ8b3}Q<Z3ŭTdNk3%%(b‘4~δ) ԎY=4م$T"h1\(a_ BV:hjpXڢ{!C1p?1A(@ъqQ{b9w6vlP yNe'ѯDns8ʢHP X?jt Lʅ 3)mwe=NZ?OzW?)x\yυ-!l;ac>`k=₣y2^pI 9$' rRNr™>r oaevġ֩!x` rev*#!@`T{Y)PqM_SAbE-\耬5~4/xcMcyN[iwx4dg0f9C~'8lwv:ZVYA_Z ^G WωkW?lg["BRUѢ'MVpX8,$W:DFKM{eͷQW\6<t) "T a4z@eм0v ]ê:xzʈ%.`)A)&zhG)y,FF]GwT"Z8J؂U2(D+X YNL-[C%Jmsl8 qLt\;$ۘͫxc ~ ebYөJyl.:nͷL%y=꾞ZWIC\:<$ J[D`CL^6 TZ*f:=,=֛mo$X& ,R|W3m$N 6VjLUI%Zt򛮲k9~;];HUf@v*W ;B6T6W!kkm@c/`9tM)nU'fgO֬aTr]P#wTdDdDw7ؕ{UuU-K2C{%\6goD`62pnBq6-o}s:dq: y1xq1Pj/יۨh_U?d~>r9uv, {-O8}s@݋w _%dM&5I)DdޝrQLlYux-PY 5@1?.ۓI-nއrL{:nߞ~yNu>Wj-gj?OoO  endstream endobj 2912 0 obj <>stream Adobed # $&& $ %4/ $('++9+'()02520)7;;;;7;;;;;;;;;;;;;;; $2(!(2;4222;;;;;;;;;;;;;;;;;@@@@@;@@@@@@@@@@@@@@@@@@@@@ $2(!(2;4222;;;;;;;;;;;;;;;;;@@@@@;@@@@@@@@@@@@@@@@@@@@@ $2(!(2;4222;;;;;;;;;;;;;;;;;@@@@@;@@@@@@@@@@@@@@@@@@@@@N""  {1!AQq"2a#3B$CR %&'()*456789:DEFGHIJSTUVWXYZbcdefghijrstuvwxyz !1AQ2aq"#BR $%&'()*3456789:CDEFGHIJSTUVWXYZbcdefghijrstuvwxyz?Ӻ;Ys2r@dȅd2d@2d"ɐ&@ 2dɐ&@ 2dɐ&@ 2dɐ&@ 2dɐ&@ 2dɐ&@ 2dɐ&@ 2dɐ&@ 2dɐ&@ 2dɐ&@ 2dɐ&@ 2dɐ)B`Ӻ;Ys$ JӺ;Ys( JHӺ;YsBP!(P@ @ LӺ;YsBP0Ӻ;YsB@@ !"@ @ JL!0Ӻ;Ys(Ӻ;Ys(!(0Ӻ;Ys(!(0Ӻ;Ys(!(0Ӻ;Ys(Ӻ;YsBP BPӺ;YsBP0Ӻ;Ys@(J@>mmӵkh3@?MΘSzFrGtι}7{F~Oږ?; ˪xeq<#c=O|MyuycdG~|gw- =8a)YV; ُ9<>wcPǀݍ{Ȉ˥>]uO̭W_.ka2Ǥɞ'~Ǥrad¹bێ\N-e=|f] :5vAzsYIXRwsdN8ߴǵ[GBOjK 9ӏ5Ve%lfSNO~qL \;{ ?k/;g֫UkGp5)8ysko}'7K+>z鏳JN˱"ߢimY1_>SR~GK5ŶO/>(ԝ+EgVK[j/xod/g?PVc{&ck=EZeiz "Ҥ2!ELfZ okb38'%BOinj| ӋtO޽ I~~eO?x }Hæ0Yؽ6Z,EGV?͇7{<9 {[?Nj_=~J?ekZڽ"~ix_X9'X*~eѳզ~oَ̟8Nvc>磛+F=8׿I{ {2{)?+sm:} &Ӻ;Ys% @J'IB|gr6lb;7oH+x[>ye4= Gս[!vq}.8>Ömݓ㾏K;~m6Qh/dogc Mz ("e3*L"DʲePe%Ve3*̬(뺧N4--i/NiFЮڜ4+g[^+پ.af1ˍZvXuO#@a Ӻ;Ys@%|#J>Z#\> zOo"Ua!\\&G # o;xw};T..?oka}q||Zmg0 Sig2PRe3*PU$PVdVea@ReY̫2+ZV7D~=+^ޭ?U>]>.mIקie.YJάN|NcΎvULeČces#~WcD?Mq{=w6yea3={蓧32#u5'֞/oύ o,zdEC=v@ &Ӻ;Ys(@3˝tN~yw}G 5-b<>Wo<<0g3/ ʱ>KSe/e$cmx蛞5yO,{1ϯ?ZSk3zD(&T{:G[jvz5O{f{bzJ֝[=S3cF8L*L\3(~:ۨcЗǏsh=՟+3u&>}gF=K922Is"Zе-[Vq1,&_)2eYDʳ$ʳ-D :4ߣV~g:G3zq}K[=ؙc\<>4^D>UӱN>98a%DGv7brӗ,XQxa^]"}L]/.6XݖX=e>J7fۛsB/ >FބV8c +򳛖@Ӻ;Ys@(!(~sIᮞm?~#~>}+W)sg>'g|p:>I#mQuoC澗 r{t#̭d/<@i{z/##xkYԘFfgku7GVX[JY^M oy|#}Yz=Q:Qg}<'cyOjNnw 24r^qjDf]{k3[Vsz-:gDӾK}HO^O n5v.g1Mī| ~ufXDjiO>s/|i՝?Nv:ϓӬkYsig|4fS2be:zshoiz/{G;3oౘM|L2˝4(?Yt4toot*qdz~kC^)tMKZ"7έ)e9ͽ6_/7q=~UǻS\+%LcDx?6&Ӻ;Ys% @MmZRom3/&e&O9S$7#|G^'.4;Zuoyϝ)^;Y}m^oai~ca3)e2*1˄=G:+̢-,S2!W{[_ILնg9}ӭGǺx>CzaZUZDOeFXraxcS %oï4nYΦcYg9CLoFf369cZ:77:Fmi}.cپ|Nsшɷ躦~N?{M:ԙ~^e_z=[9\c?~Gtt!g|61&ULʳ/EED|ҚƮoǝ?4>)SR{mIӉ>Tω9=61y?e^39zGi1ccLϯzՏWQZ?} 4ό'RtiN LۜY~N5?5;g'z,vKtct7q##@&Ӻ;Ys@@J~LR>Y}"~7GK#^i3{Mmsebg˷uϋk3e*&U&Q-€?G^үѯ>Hҵ=q|KkGط"~39~/k111k~\)ykF<}|Δ{H5}wk 3173e6+](DwΝOum";}N.ƓNc˻㏽tnѱG;jmko2'p=OLg'qZNcoJemkM9Le2f_n"ʠVIHѻ=KK{Gԥ7z>U?R:Dt(MI#NWZklO~%ÛrY>=vD\yNyr0giCijYzެ*B`Ӻ;Ys(OBh_S>cū1W?}GGЊgʜ\96Ϯ/ t=&6l0: Nm|zpcrӻqʉ&S2D? LL*̪v^4Ԉ+ҺǤt߳u-V|̫2FJeI̩2EVe3* I}Q֝? %_j~OOV hrb' wutHշkjO0JN?˪a6ScoGǶg9:.?gqӧ6q߿-ucjDm=q-UӌV LӺ;Ysg_ fm4~N_[K'[>9iFeO61 W{1Ǘ9HۻHLF=n_L)e fT&U&UXUVdVePDʳ$ʳ-(H +,Ft=/>S<13롏O?a8z=+V"?-oj}5unWKwDϻor򜧖m6v8-h0Oq_\\)m0?k;gQ2 _lp2˗z>`a Ӻ;Ys@% @.z5m1/|1靆V;mc埉1Tj&Gpooc݆o͎>}c{v/t~Z^Qie/ac76.6S,2-22Šʳ$ʳ-D&U&UjP&P "B&YVSOCΤKOO?B^ѾR=ܾ[G|9ط8Yզ~._3JsϺl0qnc?Wrga;{@LӺ;Ys~Rk}cO/thvXTi;gx^_=S6xN87qܱ4A#L*̵ (*̓*̬*L*̵ L$ҀH j%&!AYB!nK&}j[V}zVt{#?gS֚ӏ13?R|~5Gn^m=:v2~uc7k8g_QǣM:>кQ.h֞44ץJQ/?=$>Ct NS?o-f{8k˕aB&If_Q*̓*̵ L2&ZReYe ( XAYD"@ TV2ڕYA~ q(f{K]m?eu5?ۂi_7; mnEc埫:N?rrJN>c_װ"~džxG7,yr :qt q}g/Az\6gi=n)˻Six^O>G,i}[ܾ濣υ'|{fZT@@Ӻ;YsD !@@ @#] }Y]8s;]?SKӵ;M[O2/=1>v.6S/gp]ǪO_c:QN:4L9WJSS}sNҸ>>Xc .c߾e>:L-1;y_Y֢NT5'௃zg.I;3uOtKp.m񙙩by_p cř&bc|O#\io:eYeY~/ӵk]?n}y3SQ̤ +,̝jim>-~g꺫Ы](3|eë#ҳřޝ\/k9eg,3giNXn(rޱ}~#18OKVӶ֌~ :V3o.vYFq5uby{6;^?~?J~!M8卦\\fGX{:/^3WuMڗ-92Q򙹰~g*╬ۋwc/jvsizrK{=˄&U]Otݞ¸ -Ws1=s7b׽Hֵ3y{ǻ1?,>GNY:Mz;~),:+9?mIWzFi[N#ǣk}[/6'sݎ1cƪtፌF{ UM0l"cWZ{O/uXBњwG|#JU7gm6*<HUWۤR;ٟ*jIXӛ)gQ/e]S \b!v3rv/mդ}{ϖE+?KU;]N~ih-l,QĿ7[Mauc6W-m# ;<룷1b ˷qǯ}L!0鳺;Ys(" @B @@3/_>_{90eh[9YEiǔr=$Y˝9V4Ѵ\{yڬyU&U} q"eY;TI-Bt>~M~& gx9E0/OVbD|Q^J*ͧyG~JoJOvzcoNϢυIJ6׿K󙕩TRiW׬p1M R֛vڱ蘌N|UL KB)7=p|4^V>HXvm{˯ӣOoM F7,1] W?{~.3z]t1?g :_ۋ/v nakѷ8^Wsm6g~S3;.yqdL V\PP J@|/ByVg>|/|<֛/X~wf_w"6S>_&{좱]ng22D<@ReYe ( jee0Bab^Ec-U@M*ޕE*ڕx&mJmZ3 Z}h=*Dj~k=UڬN+{jNԤth?h=kM_"9 ʿoc/>e=~c ~;ok1/tlxϴS/4~J~\zֿ5_|狳z}l94a 0@ @%-<13c<߄zm5i6ǜZeϯIuѝL_]aԽ'ыxהI:6[mmxYv7nvq/̢e[u>: !>y__x47wx,W19-V|A)'䗶@8zskq\bWe£98SFYF[ gN2bwg1]Գ|ľJ})¸fmf:N{KFoվGc4#V OX/ CZ9)dPL V\"H @JtN^Fr]'lV|ՈO+]Xţ"L[{=[9v+cvLOUvپr՝"6ϕ.'t뷻2S[zYWռO\fSpyjb{ŬFwgc]ޟ7ooa|K~m_UakV{{ԘSӋμ_\)cc3&\i-cXU|#9{54ѯYg}+m J_8<6irzsa=e6%]}я>}zΟVu~:|_3Lu8D;]ս'mʶޑV'v챞G|Y wr񣮉0m8<=u=%g_G}kt>]/ehwζJ~As<yc2ݞ=wzn8>Sֶ|Fz.6#~Y5=];y8#>Zt[vv=ZGy MFs '71)=zCcr/~'~/zi9ib}x _c<1[Gz╴_R}\y~G9'k?xVעSQ^80L!0v i0P&v i0@$@&V-aH! "H0V i0L!0V i0L!0V i0L!0V i0L!0V i0L!0V i0L!0V i0L!0V i0L!0V i0L!0V i0L V i0L!0V i0L!0V i0L!0V i0L!0V i0L!0V i0L!0V i0L!0V i0L!0V i0L!0V i0L!0V i0L!0V i0L!0V i0L!0V i0L V i0L VaB`0DV Ø$ p 028SVL9 1@ 2kBq=e)LN@L"ba[),|B8"K(׳{%9G %@'L 92 2 83qI@X*=O70<&%@n'< !2LB$PL UU@@E HY*&'EXgpJg:r jSY6@P! 8$(Q<2B` A &Q!T 8e `pqgPOxs+\@g9G-*?CG4xʀ?Clj4x *G>YPxG,e<[ ~xlT1e@/#ŨYP˰e@.fE7ԬN5&"{Jo/.H=/jEiÈbz58-HEٙDHG'*[MegvW33gg#*1ʍ||sf*˟<'r^.ubq+qFO c<<[צ_Bצ&iN8"b3S3x#CR5c[O1YŦb&&sDc= [SVԤR"q^ rOQit 0 ˋSO[k쳸֧v;6<'cg_L,im^tMM9Es|r9ߣtbьŢby&鎿]{ke51;&s &9u^,Vr;}-=jg{xIQxDb{#޷FԞ=VXD^m Ko ackp9\MŚzgmmѷ1=\ ]=)Z;Vcw}Z\wYɟ8(_ivy編c2'kzL[Viych98¿{Nƶ|~kcgVqwLLOZ&'.wu=ٙ(X  ^GP> 8ejB3(AnQ4U2b`BP ȞF @ȍ1c"JF q1☬ɷ<Ȧ{UOֱU/iZu1#ahCɒHǥ-+jj[<}qЭUai4_I' pN>D|&4ӎ} h1n{{ofh)GN}f1iq_nU[ZV5Z#3.^ܭ3r/9$F\9}}= υX[,4fbIOFN.&9Q4b86gǓcӵWƯ+_W}} ץuxg1ݶHv&6ʯ*su3SQ\?v?t9Y3t^}>ҺDLR"&'~K=cJZ3iRy#<䣌 om8.b&1g/aeF1;oN}^Fyc3SiZڔᙍ~:jhַb3/OT:E9N g%lMk}{xp8&3q[lM\qv]!eߪv1^4L:[]Z"q({1V>&_Kt&i~skfm?KkSF_/F+x ᳆Xnˍ=]֝{ӿ^8b',wrcNp-e+e8N>8L=:-׈'Z'3wjO#-?$|E<,K~׵t旋f&;cg`7='᷌#*7Ga 6YY<nm-jb&*vM4N(f1t&3HglwrL8FY9\m#fboNX :Eo?^5+1߳ͫH{:s|3>oW<1<ߝ,o׮' ja\|nUv8NX7u|sYԈrሜyϵ1msü[3)¦1yfbC"ilvVZkI;i݌F#3i|S?2o1D3<T?ͷ2ǥYV]lvT-=ۼ2f|o5-/1|Yv1 OS}16okr>?seC[˿W~Df\3gň#zWuO"cJ)Y>=z磌?EҬf8YO[ qf&'gI;,pFvjg78_USWt}}N:xŷv{sg.]ߎq6&c-)m>18UG[nr8ln0ݻ/\*ޜlzU{85Ow~Z-kun}~Y~nӵ"6i+uPiIi\DsdzدIZ΄RbжqeKsJ]F9iӋƛ֣tgDe9oE_;{~ޱ϶b>wξz:կش≧8=zOݞffѼseԚW}M:Fq%wDŽ6sw<7;e3ۓShNN˃iDObϥM a(8|_*_:~zU>Q>t>ӳڳ~ΟA+"&"'SzvKZ5{];^'Jr 8>33.I=8_3D^+N,r湖MM3g9;t:N&>2LO8~K_[SU8fqǜx]/+кE)5f#Dy%/\vY26Xt2ވQ3qƤxc|ofGF#V#=xm1fXHwDQ}vqZk=ts6g3Ι0N3v;9MGy9GZtf6-wwrZtu"Yc83\ǜpy(X6s>b{ gkMffb|c> 2'rtmxɈ[WK)1>lyqLL_w);Lxs#ܽ#g[^S];FSf&mX|qܽ'SfnF"vfAssFgX\ֽ9jtV"3kgq-'Vt^1 ˃3ny|21wڌcמbk}UʳyieTS|.09]Rܥa$&#)ɬpU^{CM:o/<1qMfSg7+㗁_F2D@XN3kDPeYH:E:-'Rc32=6;;ϫt9;GWZߦRum=vwvD'CG}ىdVe{a4{cr>[$V{NYGY˖ۏ3ˮn_iX/T8KueGe4x⭢ܭ8?:e֚s4xGz?}-[DkW3{p]1t<#g6,ݔT1=xv|iUc :w;c8r.\2?7~_Oui}>fy?ANH&-[Fba͝ $3<䞷fc9(|K@@<)ʋDGgriuӴw+10:M=mI8&&$1д+n8xxc?=m/*\|ޙ{tΥÂsr:pfpZ"xbb-#)ӯFOOg qD$W6;>13u&y~Y>J>Ft. HZ|}홟ƎkG-Ӯb->ߋqF=WV({y>4ez999N|8w8wԾ"{{tmM-.)m3?m5N'9:_Wjxb'|D}N>6b96mvZD3(ec9J? l*wwWmG 3>徟XZyt9Bƥ4u)j-ygcr{z"W8b3iףjDmxqego^0 u}iR󙈟8M;KOYNm3lN[qG4'x0g8Ҏ,6\Xeˑ辜^bg3hi)1qtnHLXipEqYS |sbcT}T{m[>,]iӏJ4l}Det'~Yi13Y1@.hZcxǜNb=W[Sh>n{9юOzU֌Z"cA< /mrrl|#kiFuD_[e31=S^kisφ'c݇S:|v8v~::35c1 JڱXNs9sg驩5]^u 8/iŌb+,¶De511qS\Ӌ1Ls1ϗsXO/OlG^yWjGf3;F"2 e|ZMtyN3Jgc]u+MgÆ狎ƣs4iihiW9G}gmm] ISf۞f~-={mZTΗ^ViaN*#h|urc1ck^EY9N'n&/UŎ3<>nqgqؽEߎQ3Dm4FV3]&'G~M;W%iDLDz"bR&'ebL#AhgY3zB<@ FyU^hhNj-Q1Yэ*kg351/ÇvůЧS^WjZ-h}).3fn_z5"G).=foi#|xNsumk;ڀx:yVc߂Oq^[x2G/FNx3xWazO]s0J}mnq14|}."mim9g=w}ηjgqofgat}'Wt:'G3Zk['yx.֮ZMfcmlZt=[JԛEnD31ks8wf<;cvO5L&fv;<'ƍb9\^.63Lj5-p;Y*yk#nOWKi:~x;}=nsHm=3YИcl?9|&c+yNyNSZ9ۧ}YcKV|U~/ungONGTNjΗ݉};yqJp=cLcw~eG2"b'D-vW)\$,koFgo>NyN{<#ŖҜtm]=ZR{"c>:}"4oC3KhFq;U-~(F3WZz}b'Gm-yܳ}]kgor$Eintsfsx+iX cbqDv{"b3vxtzԶ7޵SDD}SzR'+ߌMff;< ߏku}dO)ݧJmz__<3sS;)Ö篸{iQyQYnҵ{^'4f&9bw.qP rosk{c;\1t<辿:|ug3<9)1Jqqi1TLNط1rz&3kZ翥<#6H=}(m1Θ6~m6qDDe510~Ոz13<;z5O> q4^(#g6qoö[Y\uvX|&b'U|o(|_F&cV'ÔZy{uglc9^+ܽ֬Z1<-8V7ߧP}Y{:Qs1Y/zO"Ǎv13pυmrrwBz/YSՈ}f;q~Wi"sL2М1?.Q1lrg|@?ba0 uڹ61<{>,Dfoi4yJbۿtƲVX<3zt#2īH8W9xίX9<Ʌ[جjyTijD`(iVd(-Sn31lr1)Ǭr#gu9=T,2[~kcD?z/Mb"><>tӠf9ǟ/ t[D}#Vwo=/t^"s5hs1iff9csÄFN蛞ɜ6:ra0^^tr\WpWOOðҟum{|ft-H;Sϯe9L}zcE: iXwk|ũ4%Xҵ3. a65+Gr!&dgubֿ)MGtcϻcC_F9E3\[юvDT}X)ucՎ ^؛NxW>;eS1Fc;;fD8VTsC,v]xET[1u]IuS\ƈ1Wݤ7^Uiݞp"r~zۻUnjxFkUϛ'wYDiVb6D:Zz4ӯ""f}L8N<,qUw9m3fvלߥm3JͫьDͽwݯGR#1|s3Rm&&gogzZc3߿ٹe=7gWebn|3噏~:W1[ořDci-lsjb{Zwv)qJ'(cuL8n*uiZi9L?|uLf?ߤvWOeӋWŦ{>[9}K=Gˁq<&&vw,A"YiN-9pqt}zZsY1,ॷXˤxO'[^ڗ1vz#Jf'NY׬4931L="|wΦ9)gcʴh1|V6,޽)`Eg,̀$umYy}tmEL aC/]^pT}K1/7̟Ϝ>m-l7YjYw*$XRg3qH/:y 0L_; f6k7#sRɘIer#4?m}CNM9o9ǭ>wCC_#J=S6htz/\38Gncޛ=a|e8.\^4Wb;,#GKl-qG%7|i`FծqZb#g4go[O߼ᇠeETa<[Rf'1Y.qzxYŹ'<{q-z>HӴHsXD&y#1+Io[Lw3k__={ Nj3ޗ=<>'YѬGG'Nzwͫ3glr<<\v13x6뎍x9gOw3<9)PvLDS/%;,O5\Ѯine'Nz#if"јߜ.YŇIgSRx)[/bY, 477k+ts|st0J)Kf>3wnѮ4&f'\G"(vyyY1Fߡb-g9_&~WDm'-k}Dk˥sc0DL[561uռX[KsGY_|é3Q;ze౤ѫKXCj[X*7oɼD[nHUy,n8Ӿ9, QmY@yGrb` W_/SiԞyS}Nucbw>7[,[a>ik5SGZ[Dm+j2ͭi1RL-yKG2m՝vg*q<^"-tG !G>sv:ogm&xt8~[߿5זyy^|rhvZ/ǚ؜^sSS:SkSb-3Ìf֙>]ۆ ,qX}~ڸq1Ungo0HDW:zXP'hͱ<\|<ߔwZ{[􎹶O(-lg"=hdž2 NOeg "4޵k;.8ʣ^u$󺮵<45bT5[1|F{;&m]DYyLVt{DGF#1aRjxrdW|fpeG-uuד^ӏbw'Q&䏳IQe1]?tXx>NY%Wm[xVtk+iyvNܼ^I%Yc GYh7=dntFG{|[q^q΃vX?0iݣåU4X_͓7OLőxjRVQޑR_{iDk5SXZi 8 Z]Exc1͐n_ѿQj`XZSY3[)Q9N//>նҴ~}.hHǶ[o}&9߃s>8zq{1ceڿm3Xˆ,w?e7AE;M9{֘?#к/LN-,㾳γ= eo11>vhKq;zTq>Ȍf|}zRt(ʦTy-N޶qff^m8V0DZֿvon+[3,E2<xNqzc=oE~ hgF>Nμ3w.\Ycp?,#>n9_vs͵ˍ;ԋ-Ɯb(a-wzoOEfk38~[V1hles)78cƛ4ÜtkutWx]YӧVpF-3~L=ڿ&=G*i[hVy۞g6?>.4GW&mֵ:k3>=tsiw}I"}_ݭ>蟯-tJBb8+l8>VNf4b~6<8yL4yi.,c.^~w47L?%"qw^L>6yDlg,+ti{\fv9M]"Gu-[irLDYĽ}[}c~= KG;ށn頻c|cN&-S:F6k:n>zkǜL|v5YotYu9f&#˽ѭt6xV 5N{iNƕm~{_ާՈy<_/8cci1|߅FuxzыV&9;дLќFNq=mqحkZ3Szfc^ w{;3i֋<+e^ og68gSz'Vu39֎XW=)p}'(ӟ1zFFÒHݯg^kH|1zzW~F11'|ۉ}FxvDnSkV3gs3<N=Z"wsmMi8j*;c,ʷ\ZoD%4>q"y/d⌷Zibk<9g<~p![cgӺK5"f1'ֱX0Oѷڢ1j-嬳b"wC8fb5vkݞ3ķRktkMf3ݴs:[_CKFVFcrfuc1DLNo&'h)/k6?~ןiz#[ѷ ۖs uOQOC_VbִLro xZyӋZq~*xkx鉏z?OKFm>?ڝA&i6fwmkTVٙ1gFǏq:D\/.&"f?_۩t]xߊ">|5gNqۊ|qgVh+Ƽ_/KOSq3Dys0eϽzs͝Ýu7Ϡ꺣OOԝ8:+};}UzOE贬<:%g;G=6#qe;7s\b_ѵäEgқifgh϶y?E=Gn^ubmb31Qr9HԵ6\,Ʀ70"'e73,ܵKOњ5qۗ3;'赌bm9C2-m|Zc,mi8ݏwWIɽs1ͤe8wg:638cםuER?kb>\/7f౬6PiF9ӷyC95yK7ʠWS{fS|՘~Z Jceaz[YQ )8Ǥ+!'p'9W)Ma[MkY#ӥk[F+13+3 Ԋ&'wogƳ\rg<1*AxƾHw\)xuq<}Uy"mhy KugHӚN==wxs})G?g1YĿ.y[,gkRw8gn,s1;t^=B"11'WSGOWQɆ#asNsMK>uzV=8xm]#b&8f7uzGV15LWv>5z%t"~B:6&bf#v| :'GVWOtL}cZ޴Z$G.&x+kc㺢.u9aʞьi(蟏3ҝuYJܣ<9Ǿ6}%-KsŲLr꺮ule~\D-F( =Zͫ괯KҼE38%+^ qVy~ymԘLSx|W\LN|Ej߇lF#;sM?Iѭiiqs.X~>b#U7UkYDqkM+}%mHbc>oWKffٜc{>|HyFL9f><rN?5u'(u_a{5HXyzh[)~3>r?3N9w̾qz𙝖 ,ۄgk)嗈 >G[H .5zb>17GnLbpoN=a 7ynxdaPP1P>Mb} f5Bj<&v< - 2LQӻO0.iNoSSZf&#)'_sōyz9|}<'iD=qÄcS[וU8v C:htjD9~=)G<['&>sWW1sm/JR8>8?0ze=uwձ: ffb&:"Q,,ocNǠzo37O9\S=ssE-ҩ5}+3+"xbW;LDm~XN;'^^g(cX:9|5۵Na9qwNTWkiZކkǏ(}[LZf#wq[y4O:m]3h{9Ta83tO?(> {z{8\ˤNuI[y#~b&gێGӜz]1+s;gi}xqN3}U32ݭO~Lr/vQ=LRzںW1|3Iϡ9g匾zE'kG~HgLEfq1ݻטqCjt+ޚ5NoJf>ukYF#vyl0jxD7]$|=iַJgg6 &LLZmf;[ӿV11q1}>[eV=qO#ѧ,oOty#9<8k^ԎhZ:G>u:Bqb+17>o9\gt"Fgt5;8qGwDG sfp;Hv^bUoGwԜ/,5 Mq|]kbc3 FH'Q"1b9% 9bj[eL8ƏUhϧY8~TNs{zEu/)r׿Ҟ{|8σqrk,f7pa)Ydoǻ?1崛Sշf|"@mjZ|m?+m(yJӓ1!'fG8i}юpXɆ/ߑ~QW1؋ۊQ@-[/5Y/L+n.SʹbV qꯣm"botw -&nT:JY3Vo>hV}r\[ |vp9;mw:QΪcJ4i5,t8""c30+ҕm>~f&yLJ>us<ˆy31"qՆY9ݝ7~lTv;z58"qi88mt:NZkz"-=Zb1MF>{3$?ncxγ1?_VEN~{ i8<>tտt-\bb1{yǔyJ{xO߽<gU>x;iڞiwwg -=yԴNi8qqc;5iNsi]S c򈹎lc`"&'W;lG=/@ 扔 љdjLwSLr޺;c1|^NC\cXL,]^p{hyi1/VZi'/36oVּg y=m,]9fOs,[O( bj-y̪$/ k1kSi\sVm9ixc/$]aa_F[r4?U8=6$[iF`&9&Za2HmQe)8D~ΖgT^<j>{|y1/9Vyr8<ct3畩imeJxʶЦ1;tkHQ9cnKG>KNykMóӍW-z1;q,Ѳ-˓fc矇1ҫ1ϗēX؞R:yʬkR+pԎ|QQ9"u֎q2}gq5yciVkLf#~ҿ8LN|f^HÆ&fg[լxvNÝ?x#CDO|UESL|;36w~qq*./۞Io}u8|ۦi-ݥolOVRcDLcn{3ch@")lbX#Lg.cKOLJs3F5 fg,wƞ\>oggmx3N{JS[|QA#.q:c~$khV+fx)lE/X^sX{8|n-LxD7p Xz/5i3/N%rg\ϛ75%n8"$y-(Ţ{byGrq~/ m5L_yi@559S ͸9@ L妕qbu'0s9Z/٭XT;Rа7 5&mkԮ^{1Q/lqz x/lrg. GL'IYjf'oIʱ 33*v:QR@Si$,/[ӌƛNyL=ϊ v-?R;{^Ռfrioi✑YX{KxvxODZyS?b-3}Lmm6 ӫum=򨴓 k{DLx)V 3%-6Լ7e[~5J -?[~4ZUЌ-mIc<-?9 ,n3]kG{0wn韍Ԛ/j͢y[~6xމӉ-?gNaeY{ՈʝgEr[gion3񝥼gTKxvPE5r;O|fv(c{Nf7g32mkc+M#tV8!(:Mum LKZ&q晽eJ߅7.p(;KxƼj͹L K^ֽ{Gio[g{L_VfyJ'Џl-/][gyiiǧT2Z֯|l֭V3񝥼gL<@[gion3񝥼gTKxvP3e-4P9R~5o1jG4j4^@viYT){L?K~垖跠ݷƬgyhs'R2t{ PO۔m;wOiHeL,I-ķ feż^W*ΛQ3c5㿛whzM4W׎n:;D7V";m8M40s2k[W78K}<+kJGw8eF#zo'KX;vNnv;9bx6xDu(-^ӝzVk[VsW0v9#qgDϑKF?Jj;9j6cN$1; >wDcY%?x. d6/l2[3,gk1pq6^mSׯ̤c_Ry`宔b2ɾ8I mn)"2/OF2 y/j1ٷYjr(4;dqǂ(4U Qf k[~#ۆ3xn;)^)^SNG[tZ d"&axrUD-+9+YN>[V-q'ZFѧX[*@EfZ|ՈI@LVoB` MUIm\<>ѭLYRΔw+:S-ɩ9 Jxke Jʐb*@ 9䘬r 6ӧ9WNKNВQ<2pO9;+*je)dX8Qiwqd+V+0ʐ/\Qi;:P tgn 0Y@ #8G`/?5S&2džS> ;XGl vvOeeob;iMMJ{LjLʽ/]jrI @TMc2I̧Og@Z\y3_Sp8bi)QxyO08b-sgkzigtR+ZvLVf؜\1-xĪzUPIZn ULF"%ȳ f[V8!ߺ94DdyB-x*g9P$Mcpq I*H5E+^R >( +$8 P`-+N#rR܀4jۉ+-m1LUg+Gq),{jEe246\ ߁mҋ=_vP{ziޕX6Ҝ+F%!dkF8'}RRb3c"grVR^(]ڝTP3>I'+N&19] pŶDRfpIG R0׈@x3ܬSkg{EZOƈx_hDZ[V8cDX NSmI)3i ӯ|IBޠc3Āh9SajM/q,*<#xU,eŽ |He5k`ejpFƞei2mU5t ;7Y(^;amLU8ZL^;3Z _qDm kD2HSNl4-bFe[{gkMjX /J;K*hZ5J8j׽Zx g3ٶ~jfQzDG9Mk[+{q oFމcPPq}H$iӘD0mUhxӛ/61bSrgkMӎyJ,)_=h8k Tf ;pXծ',o8a+{`㒑8&r*/vP &Z`([Snri2Z"tF#,Qy1d;* B~ OŞV8sfQ@1YDVB=V&}9Q sx;[roݺ-NLz%ki*±8#9Ƭ<13 -lb%c2d[m?kNsy\x#Rbrb5!Ig%b@F90"ֈ!f,ZjbX8䴠/8%k{^"fr=brV#(zz1^q8/T^dyb;WDH = Ijm'i),3^}X;Od-6G d/M+8m?Y.pV68 ь"bfY10 #Y1zHnζ\F1賔$nMsfw 19-N{>` E"r M(Ƚcy% JHoi1V)][b0ʵ$,Қ^+EcOԛ)T"P 3` R2sy9 ӎy5)i 㴞kZψ VGedfs -׮qϹN ^ԙxcm8W! ޳[O?ū=OyiiiӇ9^Y_RlG&w;w%fɭ;b(9m9!8<6(NE18^)ZFaM/6ϑK甦9 qZLZ|NfqWNbs%1 |@♔[44vs*jGQ}M@Ҷ$ծ'FfTXBy̪o5i1mNU+ P_tZQ^mn)L̩J佸3 ϫ />(m*)6Z}5em(e%`7G&x[O D}Xqs[MB/5Fa@L*j_Sm5#1]I̭=WNUU15kx) Oy:R'Ry4W &ZKxţOq2 &kqM'@MJxk9$k0Jb':7Dv!dfHכ& KE&ʂ[M9n*>Y&Z־V~"Q1Y"/0@ iB8k9R#! b31dA [_d&]̭<Ԙ58yJ6"Laj_x|rE5BNQ1iOd|Iyn_IVP_GNbT;ᯏM&wR>Uǂq\g*?0;;'g04_xg8Mk6iŞQ"jͦȐ@cӦ91Ro9⼔ʅ%-WFZgu@DMi|r39Bb&r@}(ᓊsHM˼J_Skڬ0/*Xiyi^&bVu%zR39EtkIk3_6DT bc%`Ng@?lM70&0y@/^Q*/}%≌H@;J'N`(X6!0dVծ9p[Nexg(jwG(޼sȚW MZ(MZS Ҝ9z"1e}9`FՕi2qX& fd-:s &#)ԞffS6r+sN3x:b!` jĚ2pVQ8^Po7ijV;(ڳf[`>#|E'-/|DPz󬨾V' ԌJۜD V*ߖ2fcRr`zOg9Sph)EªԷp*&@4RϚ;}^@Bu=dWtq9 9ĢcPjoV՘R֛ _g:z}4y.HjEXd I3`lƟ^rOgI1!` Zgi*Z`@fţM9J-^@ԯ8d58Zb曍 R%5S"-Rf5h!@xf@Q[LT鶘^l_yU˘'\pFT$ ^8bm1Xf #S3-34㌆+mLLsgx +&+vs& |Hs(qH-Dm<fp܊o"nNf5YQ}9| M-3%te~/]?X^p&w@1~S-s(rVcN\MJJ8mYHĦ\•<<1}&\X-6 jy3uf8Vxyʼ"#r҆S974=F9ʳHI 'P1|;j5mUL/ -ʱ 5b˹ZW8x'ImOے& iț Ӈz9Mm b@d L-gxʀXT_O?ZOw%Oe1ks!8ikEYY末u vŦ#R4ђiɫL/oJ2yf"V'1MkM sֳfrgZB,6J8P$}N%!}N$id9@Ԍ/Iͼ՝@/;INi"#3(%4d ZE4y}T^-(8Uh`kc-|s@Xm:in8ĩ5/V[ޛ|DF[y9 1YZu=b+1&r&9W̦"&Qkf"nQ(S\g5Ձ Wښaӆ=i@^-ZOuVns1PZ͖}(P&^P#ڤFZWw w@ j³=.+nkjax<M͕,+iӾUԿVּH֞rxYK^qP^EmšW<6y -[p|l (<A~(Mf-}]iY`wkwm|cJ5٤R#K_)VVm6@/oB1R; B3^{Ƚ}o/8FQm:M˼1 Eĝ=Ԙ'xQneRjfQ515f(JRk9RVᯙH(,Gw&[N@ 2\JV՜g1*ڒWL0 G*ʑɭsY ioJcҘ&z -H̪.~ gi8DiB0+9Ы=8̭2;3i&kTN9IIĢ8@/izđP18[r-:F XsP&c^5' /|:sk^k8f/~Ds Q}N|Tβ b2 ܊͚SOtNIk@)Jqsgk͓]IE;9kJB1x%bNo)ZQYZיOQzVkBJ#r<iJ{Q@F1VB@ 53sI7&r 3_i<栀 8kF+# +5c,ׯ"Hk%&7MFޱr S+Zf)*gn^'w1U - 0D|ֶЭ56s_Su9 ^rSuh9mn)D@[eiF̙|LUβH/|T^y@G b{riʭ't&w@ R*R Ӊ:V9B.Կt3I_ʋŢܥ[Vjcc#Vg /hFa o Z8Uly6D@OtQ&%[O=k1igJa/O5vuv+ϫ />*(n&לrQk*ԯ}NJԯSrބa51/Ti<ӫ~rew@iK[e3*k0BcRaj-;{y#EfQnb[U91X =^oP kȚE2Ԙi|aʳ1Y-4DB DxԘPUߜD uc1Mң@QG s$3^ޔeEs"{;-L՜Ą(*/&Lƞ۫}^si' P|־е)<ռ\+biŧ% -Zg'eYRmB{:Y`ӂ*P+=agzy8Y@ L7*ʀ)xgk iY&2mm54SӘ;i54'JddYLMMVX˕Ek N{ִL,6H݌'\sqJ {(Z+Ɇe EyN vg_J0 ,*z1E7V<2pE5*vcZ8 X;Xbqml5E[jp{U( KSs>N7WozĵȻ^I}> ZU5lE2)(+rfܭ6g2c2Wjׂҧym\JJƀ ZeZ;@ _hQLLH)&mM_Wu@O Ӎ_j@& -0i=XGc,DiDx#wݭiDT3궝8,1u8*q@ޣ|Wc%zm-=a3ZPNҫe0q+v@.Mi9i;h5*&et$̝2jhV)M8dXUԜ;IE460m3_VT ON3 ZȕhiLsf$ O'nKRmvr,ρ:SHf0pd*&g+iӈ7-Lso~)NZ5&FKd),ve5tKx)RHLIy~QYP,n9G)6Vc33# @ּ@}ԜɟGEwk8{*s$n)m8]I`ԆvӚL~M3LN_/q E0RRGƠԷ&-3yAXP,k'bf|[km8*M9iiCIRi0Ygu* kdNe2i{My1*9 'kLrgNBY;9P3Yq$jL' -˛-8̵ʖᔅ 㜭{qYE6jF}{Hʀg0\#J't[S2ixl{ʱToniynqt s NZ+Z*'<@ZۆSzQ1Ajl6|Z&)6&-^ZS-bR kQ rgmY&r- /9XlV7(TQ:s &` qV{u8q1I@ŦY+}IJ[Z^p]-3rk(l v-3&kix=2^Y@O ^H1@ 9;9(/:RPB3%+r@ )ĭ)oJ|еfg<]ySV=y6yrqd~8ЬNQmysZ^@}U,m6)3)'uDn̪ K[ɞWOzHѩ=VrP Zi5UhhƧp+JȵkW1H$4#N4SzZiJrpV՚8 LVfp*ZP^ݤvy֭,H-YƤ3 dָ%kr m~$Ţ۫ M;jpI[`c&NSHqV{AGz0* Ġ#|U^=(ǁ1Fa{e|J!` ZdEfKyQ-h҈Z1(Z,B֎X13 khԌJ@ v~8c WWޠHW -IĢ8ۆr$&bϸXg]9HVڸٜP -H,Q}J€ۆVsZV2qR NqFQz ;3Z-pdDexyOxMf' ?Ġcq)q]DŦzި4ڔ [i1N$^2}4$bd7 IS1o4+_O3x/Kq%9 fۚyjdxdLn EfpwDePi<'rx4ֳeQ7͸yB#DisRf5ʔL-4ZDpE|Zm.`Է t<^1ZQ:>@LVl WpRf'[-͜xrNV9ڔb*_+Ǎ(UI+6|LKJc6ZҞѧvԛ*frZMPkN6s93jy1yeh7+^s܈ԘZu1F+o`kob'N{ID3^/2[i^*f&]jjז&0m"nEαRg-oIɮAe2͚WK3RړcSHi6&ӈf}E9x%ARjIxߐPƟ#+ qEvVm2La1OAgӌ)=ؿP+iXE}e'x(G} [5x"v=YPPNa" v@^1%7^f-VR-jknͦ2w/Nq0i81 ԴU@m6ḌE3)OԞh 3g g&\:S1<<#V9o^(gyX&5Qjge"my y_h;XԄܷ` v?d+jR$*/NyP0ҺY(H1 6MQ R*jL5G YI,r~i<յɯ*̨$-Kc}j`dZ2ә^"&1hZ[Uxe G -Z 8*-18k,Ti^o䙷(Rfei>P/Y)դYG9i6k]>r`Z84F{НufۆrP{S3˼RsI xrPLVd@&1Q fy[1}G 鳋 YŧmZO9bDMx=QKc"&o2i!7*i2ֻsVo6ыG;^v 8rbt1Z+m_8X<׆PMɤި` q8Z+j1S9ymFTZEOk]_N9d)y}z NrPZ4M +6[5yZ=Uri< ` ޳Gs)'V31Lb8b#`Pf0޼-ֈa&V ȵ5Ek6V@Vsek͚ϣV fpgȯ81q8LSZ-PD[+~fD,OKŸ19igiCO<j[Z)H'NsS)Źw+5 jzʭ*$ R3*NYu')Df7g'lvyH_4idᘬ[r;(/ϰrHPNykYkF, jlRe}^|S$,[+DJלLYqpD"dӴ̭6Fcr8ED_I)9Vi*j"3Gg$Mm+=ᯜi&(*M4gBwF<Mm9_5TReR mMk{{H*1;Ju+!@ 4Lj12c2 _D(S<@@j[UZ%S#=R@ cexwY&jFd u7ǂ&y]< _4ͫ3x+NQ2Zaf{fE#y{[&PR})NViKNeP4J,fP Ҍ)tiXZmڳ;+]6Ԏ(`-aMJH$@]֛pXN '}+[+'ReP^5"AՈZ1x2khYU[jljXhҬf0+^3q-OWh59TֵGi*kGf&\EK^of/MNjCyKHBjC+RjA0/Y)\!Ed Ef|!F Je7յbrZ/" ZrJ4㟐r&ڜ813kV%-HRWe&r(~JyaDZS$'NfW"Xcy4X"SxZ)ܝOJ|qF%2z-+JN E7@LNRdԼĢZC[S!^+NbSa6qtVc 8gxM9"f_'xFEdfQìOVt)[Z{ "pq)7M'YN@i%2ҀLgu-ii8k͓nV8LRl/\Rsfj^jLF4⻑)i,k皫ϧ[pMJFaF[Rxyeȳ xߑI*Xfd&+2 Wy7k5jZlRl +_jcR{3Ns3˚fc/9)lKo;s6&Z2^PŮԮ') :Զ%Tfʀ(Z'^r #OǑ3,3i"p]yƜZVkDlI5xr ;pQ]17jڶHcZ+^*7Y0}jW7|*&Nb@UʰihC8{LO ӌ{IZ@@S3hxbQ@ʞV֛!j͕7*ҺYxQKj"/3l2O\({3Z1)/{p}䢤K=SAd&#U+VqɷٕCx3jϋ=K^(H 9Dg קi=ͦP/>yz@VT^J h{L ` "Տb8"vtkX~ nqE1%ܳ r[EḼI$Z8ws{[a4LxI l 嵣4Ҷ9D3j׽ۆSzQidi$vVg k_j&*# $),+rFյkltZo2bebFW?Gi)3kYkLNMxXi](K(I3ԙ&sg&ieiM D` S]I41ߚ&-5klV 18ޢv! I59-:*+6[+陌K>P9ۏ5ђmj%Z'-uc0>^*&'HĪr*4x}%"p,-Kps|DN{ٶ^2B"5GOp bc0 P׌Jϥ_%@*//fKubfKgdqWAf@⯁_,~(+hi,-nJqDŽWBdn?drWNPg"ѧ2FРbebo25]̓[pVgoE'N ڙ<G Wt紌x3LN'"X8G_hPJ)5n՜^(5L+ 8)2;bQy@8}Ib&B/q](}<(Yw3̪/])5kWNeV(|րqSe6 Դ xSlZ|a[>kzmv昞0jga,Q}J gz+<3֎8M˾ Ɵ#+&kG_jiIEIoU1YZDnNTjM2Wӌ%-&ڳ;3ɅN{+:Ve7ߙx⌨ ^WP$zO%&0l((/J2grOw&18֎8`JȾ4Ym9)Ǵ1%#@ffP |mԞhzTMm~*qB9f0/MN^~l0/Ջn] fT[Otk=9Dʀe&$PWUi @"2Rxc 2Y̋ vZi0b v!<^f8"v)S~iif(ּUIZ(2κS-9i'S18e3nZڳ*fF|o 'Ol޾B*DzV`5#o"S38"{HzUgھHc<:ĭ|g\)@ a/}FLG|+ʞfBݤ)VR8m6i]Xa$5 Z"+6[+&>@iy*&1(g$^rbCӉWWӴ̫ Gi& 2i'k*XݭÙaJĀ)I*|Pn E&VR3 Mk_jbݧ&iXe:n^t ־=8ǂ-Yajge+Ҷy2LN&ԯ ߖ39D1Hk5mi bu'P,ZMJ#rȀQYtogmY޺@Y6v՞Rx+L9BI"(Hn̦ޜdPɵ{㽚w|Ӊxe66/h{UɯV+2'ʋ*‚H>^*4$1MhԌJ` bS8s(m'Nq+ڙ ֥d,U=Z4翐"8)3_4vm>~z53/:("@|1X3^ެ35ǀ3|N'NZw-+9e9 Gg+iRhg'@ MVb@ nR5Bտt ' z>ӊҷ czjt]${kgeq_5*Fg@K_R'*&/0i_5k'J3"/n3Y5g2;J'NaT`_"@ ׮٤iKL%}|,Ef}/*c2et+@{sW^s(XڜԞj&#)ԞxM9sP:ī-;&`ZqGi(X|[NyYm)wJthNUf=.J&=ʐ+S^@g^SZ<P,xcpvNIGH4r,3 V{Ġ0g=fh՘Z5 )%-/Yr8]=(ֵaUB2[N3+EMY1i93  oQ13 pEw;Llw)rm^9qEv/FTpfd؟2)6N+_h"i9xbmL^ړ>&oBb&ZWJ#uBրVeD. ra32zfrn'PKE&SYP~guf%'WpLѯ(XnI@q5 7>]e 4iZM31$D̊|ӧ<}4ݷ+pZY%onek͚jĄ@ӧf<:*_qyLqCF:A[[m6Zެ(A 8gvuݶ+ 9ٜVRTT}=/<^G( OE6@_SroTW2qJ[|N9BGi m,$Ɯa=&6ڈ}3OCmL*M;&mxn;_O}M,$ fPb'Rs+G%/'rS9@*M:Eº['Sdj72Rayf4!`=JV!2`}F6#KuNpꭧ L^!E; F%4  IԌJN"az'dFЛZxbTַ XOKn*/oV[OuV h /ǝgEP"b "QHP-Gc kPc " /jnLH}O8Zk~tevE eAPjN$q8EwZ/]8<0u6F2PVN%Zhrӆza ' Ӌ5+kMLn ;8N9a{lʻJ5Y5Bj endstream endobj 2913 0 obj <> endobj 2914 0 obj <>stream application/pdf Print_200x280 2023-09-05T11:46:24+03:00 2023-09-05T11:46:24+03:00 2023-09-05T11:46:24+04:00 Adobe Illustrator 27.6 (Windows) uuid:7e0db113-a554-4c3d-bd23-117a4af26366 xmp.did:49029646-6567-0940-a925-6fe17ceefdbf uuid:5D20892493BFDB11914A8590D31508C8 proof:pdf 1 uuid:265584ce-6b89-4708-92d8-fc73ce2abfd5 xmp.did:1eb8a2b3-49e5-6e4c-9e9c-f67b70276c34 uuid:5D20892493BFDB11914A8590D31508C8 default saved xmp.iid:1eb8a2b3-49e5-6e4c-9e9c-f67b70276c34 2023-09-05T11:43:15+03:00 Adobe Illustrator 27.6 (Windows) / saved xmp.iid:49029646-6567-0940-a925-6fe17ceefdbf 2023-09-05T11:46:12+03:00 Adobe Illustrator 27.6 (Windows) / Print Adobe Illustrator False False 1 200.000000 280.000000 Millimeters Cyan Magenta Yellow Black Default Swatch Group 0 White CMYK PROCESS 0.000000 0.000000 0.000000 0.000000 Black CMYK PROCESS 0.000000 0.000000 0.000000 100.000000 CMYK Red CMYK PROCESS 0.000000 100.000000 100.000000 0.000000 CMYK Yellow CMYK PROCESS 0.000000 0.000000 100.000000 0.000000 CMYK Green CMYK PROCESS 100.000000 0.000000 100.000000 0.000000 CMYK Cyan CMYK PROCESS 100.000000 0.000000 0.000000 0.000000 CMYK Blue CMYK PROCESS 100.000000 100.000000 0.000000 0.000000 CMYK Magenta CMYK PROCESS 0.000000 100.000000 0.000000 0.000000 C=15 M=100 Y=90 K=10 CMYK PROCESS 15.000000 100.000000 90.000000 10.000000 C=0 M=90 Y=85 K=0 CMYK PROCESS 0.000000 90.000000 85.000000 0.000000 C=0 M=80 Y=95 K=0 CMYK PROCESS 0.000000 80.000000 95.000000 0.000000 C=0 M=50 Y=100 K=0 CMYK PROCESS 0.000000 50.000000 100.000000 0.000000 C=0 M=35 Y=85 K=0 CMYK PROCESS 0.000000 35.000000 85.000000 0.000000 C=5 M=0 Y=90 K=0 CMYK PROCESS 5.000000 0.000000 90.000000 0.000000 C=20 M=0 Y=100 K=0 CMYK PROCESS 20.000000 0.000000 100.000000 0.000000 C=50 M=0 Y=100 K=0 CMYK PROCESS 50.000000 0.000000 100.000000 0.000000 C=75 M=0 Y=100 K=0 CMYK PROCESS 75.000000 0.000000 100.000000 0.000000 C=85 M=10 Y=100 K=10 CMYK PROCESS 85.000000 10.000000 100.000000 10.000000 C=90 M=30 Y=95 K=30 CMYK PROCESS 90.000000 30.000000 95.000000 30.000000 C=75 M=0 Y=75 K=0 CMYK PROCESS 75.000000 0.000000 75.000000 0.000000 C=80 M=10 Y=45 K=0 CMYK PROCESS 80.000000 10.000000 45.000000 0.000000 C=70 M=15 Y=0 K=0 CMYK PROCESS 70.000000 15.000000 0.000000 0.000000 C=85 M=50 Y=0 K=0 CMYK PROCESS 85.000000 50.000000 0.000000 0.000000 C=100 M=95 Y=5 K=0 CMYK PROCESS 100.000000 95.000000 5.000000 0.000000 C=100 M=100 Y=25 K=25 CMYK PROCESS 100.000000 100.000000 25.000000 25.000000 C=75 M=100 Y=0 K=0 CMYK PROCESS 75.000000 100.000000 0.000000 0.000000 C=50 M=100 Y=0 K=0 CMYK PROCESS 50.000000 100.000000 0.000000 0.000000 C=35 M=100 Y=35 K=10 CMYK PROCESS 35.000000 100.000000 35.000000 10.000000 C=10 M=100 Y=50 K=0 CMYK PROCESS 10.000000 100.000000 50.000000 0.000000 C=0 M=95 Y=20 K=0 CMYK PROCESS 0.000000 95.000000 20.000000 0.000000 C=25 M=25 Y=40 K=0 CMYK PROCESS 25.000000 25.000000 40.000000 0.000000 C=40 M=45 Y=50 K=5 CMYK PROCESS 40.000000 45.000000 50.000000 5.000000 C=50 M=50 Y=60 K=25 CMYK PROCESS 50.000000 50.000000 60.000000 25.000000 C=55 M=60 Y=65 K=40 CMYK PROCESS 55.000000 60.000000 65.000000 40.000000 C=25 M=40 Y=65 K=0 CMYK PROCESS 25.000000 40.000000 65.000000 0.000000 C=30 M=50 Y=75 K=10 CMYK PROCESS 30.000000 50.000000 75.000000 10.000000 C=35 M=60 Y=80 K=25 CMYK PROCESS 35.000000 60.000000 80.000000 25.000000 C=40 M=65 Y=90 K=35 CMYK PROCESS 40.000000 65.000000 90.000000 35.000000 C=40 M=70 Y=100 K=50 CMYK PROCESS 40.000000 70.000000 100.000000 50.000000 C=50 M=70 Y=80 K=70 CMYK PROCESS 50.000000 70.000000 80.000000 70.000000 C=61 M=53 Y=50 K=48 PROCESS 100.000000 CMYK 61.318374 52.971691 50.496680 48.303959 C=79 M=29 Y=2 K=0 PROCESS 100.000000 CMYK 78.554970 28.943312 1.669337 0.024414 R=30 G=30 B=30 PROCESS 100.000000 CMYK 74.837869 65.377277 60.064083 80.074763 C=98 M=56 Y=25 K=47 PROCESS 100.000000 CMYK 97.656250 55.859375 24.609375 47.000000 Grays 1 C=0 M=0 Y=0 K=100 CMYK PROCESS 0.000000 0.000000 0.000000 100.000000 C=0 M=0 Y=0 K=90 CMYK PROCESS 0.000000 0.000000 0.000000 89.999400 C=0 M=0 Y=0 K=80 CMYK PROCESS 0.000000 0.000000 0.000000 79.998800 C=0 M=0 Y=0 K=70 CMYK PROCESS 0.000000 0.000000 0.000000 69.999700 C=0 M=0 Y=0 K=60 CMYK PROCESS 0.000000 0.000000 0.000000 59.999100 C=0 M=0 Y=0 K=50 CMYK PROCESS 0.000000 0.000000 0.000000 50.000000 C=0 M=0 Y=0 K=40 CMYK PROCESS 0.000000 0.000000 0.000000 39.999400 C=0 M=0 Y=0 K=30 CMYK PROCESS 0.000000 0.000000 0.000000 29.998800 C=0 M=0 Y=0 K=20 CMYK PROCESS 0.000000 0.000000 0.000000 19.999700 C=0 M=0 Y=0 K=10 CMYK PROCESS 0.000000 0.000000 0.000000 9.999100 C=0 M=0 Y=0 K=5 CMYK PROCESS 0.000000 0.000000 0.000000 4.998800 Brights 1 C=0 M=100 Y=100 K=0 CMYK PROCESS 0.000000 100.000000 100.000000 0.000000 C=0 M=75 Y=100 K=0 CMYK PROCESS 0.000000 75.000000 100.000000 0.000000 C=0 M=10 Y=95 K=0 CMYK PROCESS 0.000000 10.000000 95.000000 0.000000 C=85 M=10 Y=100 K=0 CMYK PROCESS 85.000000 10.000000 100.000000 0.000000 C=100 M=90 Y=0 K=0 CMYK PROCESS 100.000000 90.000000 0.000000 0.000000 C=60 M=90 Y=0 K=0 CMYK PROCESS 60.000000 90.000000 0.003100 0.003100 Adobe PDF library 17.00 False PDF/X-1:2001 PDF/X-1:2001 PDF/X-1a:2001 endstream endobj 2915 0 obj <> endobj 2916 0 obj <> endobj 2917 0 obj <>stream H\n yܽؠv?1qݚxџFKR ^`MJ|ph倿Y`PZZ\ GYT]w+0Nv[Nf?8s{߬DoWc~pB ]ҙnBAvh$;,hF  FP} Y':>]!r?F.=?E>y.693U'/^{~u`j<󆓄o[ᖋXH3,| JlT~_n){ endstream endobj 2918 0 obj <>stream HQkLW2(`aug-"ȪUb}.LeԠ(7HL֪56H+E1DZ\r*511m )!/@j(sC %2U)*.UgdMKLr$,RYIBiRn)cp*)~VS\CUd_{<'eȧnv+NYPN$SJt:bw&Hy,)>!r DpƮIsuBYF81\RIndaqXR=! [w`kLB0рmoK[gq>OͶA҄/xBwѐtFc4Ð!75JY䇛UscV8>[/Mb u~|ʕ-+db:G6~XAk`' +4:ݦ\E=xr 2z!kX~W, !HR&KN;UGY bW Y^Ϛ``}&%7K#:>[b:1 #!E4(Xf+@J'07p# sj-_]}B2^;[͸]&p]gooQ7Dd `:>l.q9oōZ'ݬs: 0]e{EnfS6%>o+"$ OZ1ǭ^8˲"!w16 j5FUPo#ޏY/CބZp|wĞ=1W2SrMm[ab7c?5u_س8v91֛k]ߘ7T-f:IuMSo\n[A͍cKG:?XYi;@# C6 !$ | ֞>^}hnpr(m4=?q`B endstream endobj 2919 0 obj <> endobj 2920 0 obj (/D/Work//2023-26-12 1\(87\)2024/Print/PDF/WEB_RU/CPL_1\(87\)2024_advert_preview.pdf) endobj 2921 0 obj <> endobj 2922 0 obj (/D/Work/54@/2023-26-12 >;>?@>:B>;>38O 1\(87\)2024/Print/PDF/WEB_RU/CPL_1\(87\)2024_advert_preview.pdf) endobj 2923 0 obj <>stream HWˎd9W۶᰷Lk `aZ 4KP7Rn~+-z?\uؐR^~ˇ^t?|~-_>[EGJ.yU,׬kr2:tԲ^/~/ /Kva.VǪM /2Uô!85Y{m͝ӱK/>$ˋZB͇eآdʩ/K[ڒWmik% gGlkmn( sS]w6r*s}xZu"X֞$>_!tMqvJ2̹4հsþD7̆D!\[,go!-pH3l`nƫ]+DԭB^k#oB\q=b0:t3eUoU)H4bl(6.z ȷF{o뾥2)i`8e]"xa<.9 /$<ѝ ) a1vPez0lf&Op(2+/Ĺ43}F)67{"Půev%"̈́J c8!]'d᣹3{KS޳]^+_O*1L:3>( Jpرfw1Wwv7>$}+CR1XIsA(\登kNC4fxdENv'N tZmk"qb9 _C{mf<8mg$OЕ< <`c Zxv!Zo|I!u,gS̱ 6!lݔV XIɋ!aH[x2C=6cgq s x34z`wKyوWnEU{ xbD z*v= ÇÉoұ|P ߃+j4:5jqbÒm‹x7#ύv;ZAy7W|ADtf >J ;$3Z1L bZg¬pʌ+xA}mxSd(Xq'T<;AAU+CΟgM/Ǚ䍰|0=r@ ) @j4a@)U–yN}.% ܅&2Mu1Eނf{ P} d|HӼ<1$i/`$8 J˜Tzsi$~z;Rv+\;Յk{ j![C7<< @1MKk1a| 6aF" s.g Ƹe偄C"clPXhh!} Ad2o-VY2?CQ E"wg6jaA_z̓{lv̫3s<d7E%Pn >&.P@tU Si?Z!lF6Ucv2 5D-{72*ؠ:LE~& P>uoDHX/q~5cRqa,oeL%HCy%nKgL\WK 䵌]6sd8{Vyq,BAj|%S׉4+ZF `F` 8`QlZN,pƖp&"0_PNdLqYn_Za'Bw,V#"rŎw0(oս2]<ɋdx\H+7pcOɑ }@x54w73:ĎΆnfq$/Ջ !{cfR m>!lscV4ĠB}j; ~⍵oZ_ 9 鍙Cve@f@Ym~pc@Ff!^c!z) GfbFw!oY- F A1VG,` JrjZCAp,ym֭Y(2vn/dNUw؞@bG>I.>$H.*I"\Gn ukF qlԏFY@AU@{lq}Y߱b} Hn1XsȆꚒ~}FҝؓsQ[(|,~m,O+XDq, j;Q2S֙E5u)vkX#:h<+b!f0\/XCW|F)}? X2BO X+J6JeKRj蜁?z$?m*}z <(]g ('M՛g3H&s|(Sy?1yձDj U#.=D$#D❵BazӞZMKh@!x> P`xD}sH*IBϥ83)6QyIq)M,=k~P#iPL1RV E`cN{BJ #ig>T-`gg"+8}$Gr :<ib2D^!]CR%(tQN$DS gGn9fsAsd#t9~f EM u/iT< !AR@S3)#/?KއS'zL3o~x̑oLWcmjBTj 5mN=>Sr0W2oQb-,t@^si8#.=rU$^A`2YG14.eWư6N4O7^z|`-6X?, W,sCO,"QLɎվ'%3N$ZXpIM4P !/X2}'TݥER*4t+E Zyp洐x{~+|.WrY 4up4,1$M+11SmohGNxƔiR,M[+ (_p8IGX_HLf=k< ɔmPC}z_)aȽXKBP!2m N:5|忈ƹwZu qǵ?ߺD~HwjB)?VY`d'KCo LS>EK&FY]ּ }7 ilCw{&% 1k.oÞa; \":GbH{JV \ `0q<=in8sί$e'RY ]>`ǯ/? `25;wFbETrpX;|^^G'ؗEDb_"f7#&Ԙ*HAP:2b7惑`OI}aJ (GØC1/=L Cє 6"4#bZz7͠:n2YnEv (IyG6^lBe(uJ+ k& 2732l?7 k{ 6!'V8+7v 3Y4(CvU:<-.Y Pc 8<IfSgg@eKr! `׉ Sǡ$"c54 / |Jn*G.4WSj%K}/!dW|J:< P%6 &ͥ *Wqj-}aԵ,@ǻ-2'(\oF1Uɡklpm|{g 1}WMdJeA8'PPz84 N֫ "aG %_ Aw]dUh쮳j*NDY~$r}N $%~oݚE$Vu’ey i'H+H67(ۜG\E<;!Ȓ^pMt[XޏAqN,#i־r,鬹N7[fQ[w yhjӼ !t}[j7|;KlS'}En-X{Zz%~,*4d:AJ_~ f:ɜD+D ;KnWL:YKw5+2ײ.)c<WaxϬҲiE?akAoFrzo~z@ciB:;<~ivk 7H5,5E.epzCΒCTpM-;/l,P oQdQBK JS:B V/Ȩ(;H:#ќ^:H,D+F z&\7sv2lj#s6 G0HUݞ+l<|6+%kW!U j*M2'm^O'R$fpU|T1!,@%1Bw<2YoU-3Wc:^We.ǯ'oJ"K*s W9r->|Px YA"'M\_.V^g|6SimFȲJu Fښn_TX2{z YOq-Nr/q]q #>Uq;l+AqYj=4A8>yPQ(؁d%I"b<] u ?"bPY$?j\1PqjAz$#_=n095:0*$724wѥu:qdcU]j6OKm#.ޥW{:DTg"T BBrxn4YK+xkhJQ:h:vj/lD'? %&Rr4Íu %^Ցɉ! *rww'U 6IL>W\& <)^!`wNUiqkd9;ShM*|(Jg?9mX)!,4T=L3ZّTz!H@598"wu3g1)8s7p?E+4Gt1vʂ, H֨;o3RJQsHވo<]qpL7rR/BuouMh|- ؄ ظmxjIcanӓO$Cex'E%׉y 3N.q^8pGtg:2_5؂bF~C7D2)G}("5<[ٜ"$1|[{C 8:){ˋYyU[lӨWFePI=oֳKИԸM܍V7ɿ,X˪!:Ff XL0 + ʎ]OhKAv;iE#AMV):-D.³BU;]^ H}Pg٥D“T3Q)!k 1$wZgVv^cϐ=34g;ndHE+l"TGG`RJ62Eס˅<2EOu %HР|>vcF>zQf^3ǀ}lI7P?fecǬQo oh86j7 ņő\ +mA!`f2f?=t: @ՁLk"2*o]gDQ|YՖtG TU]:GV0 4=Ȑds!&s/2%/R= SS.G%FuMjڔya9nvvՕu7R 0|O) %MR-u1i c=ni }IY.s^{`Μ rn iSyx~?seH)Uz8qYh 1K#<Δ-/4L:0A,\c -p4H1TMϙ.J,5v<dQVakl#FB M%+vV=fEHQuϺ!JaHtMBBZ%ܨ Q= $JJi{sB})\H8pG=3Η#AE Yӛ`fvf:%I4Ubk"İ@axZE&9E[Mbܮ s(_Ha+'qSx4/ԘRLYO4yHnq?T=uլtG;'q"fM%zmik(gܥ'?/`4`餺%6wY#:r[Go_qJrﰱ/YD]g|G45-蹋N$5$fTQLًQ)]Bx:X;‰'w ?UfLhGuB#OfUzM|K("XPn .ҦTxqRnL$cGjq[㽫<$ѵ-v;CNn9Bd,q\jЃ94sϓaI*='5rmn6F{hk'].e!}Ȍ:iDVڬ<6EvvȆT++=إk Y S٨- .pTBi]G8͈ؗ `e|be H+'~ypEVLrk ^ŃDHM X:kyR%8 ?/;}6 h <XWu~N~$[mEUj SZL_x?] ՔnGFDu9[e9 _~C  ~k-j\?(_2qPfsδHuJ$Z?zy͸^ cԬiSQt)X&!?lǻXpR Rh<xά%p=3 0a&a.UL9*;35.dn]ӯ)G0tjׅJ(9!b}1MZHSIJ.6Zc}By /  ɌjXeKiSQx9 ˵$Z@8Bv'j Yݨd[q\$A1Y(~Q(ӌrWƔF'- }zs}Ҽ 2 v"3DZθlvVڂ1D4'D+(Z gl2U1}bdEݮwi d: SCt7|u$Ϥb5#2S0[+ 8%3B !d+=/UgQkbݠT 2򐊗D;qD:QỎُ\qҪ T:{uJ^דwZOMfdl 'TcͽEѳꋒx!lHr^# \ uNRu=y׺ʝc %te:IzJ*Ůz oZP_{[C'mex^OOj=98ODdIkMP.d-'fï:w0b5 +6 ٪tb9ˊbk}\g=@DH8uXB+sJ]fN+4O&Kb[u%`nF_]؇zO36_ `!F/QF֔άHac%Sv$}E~Uh */4@њ"u5_M<8.3BgH|+7uzjFnfǃ1`QJ'78$ ANo@EЌi (U@)(3F.-hy&B1 إ<(K^G+ ɍm*o4_zqRikWtuX@{nkù iHv *^8PWEN? +}]YHYV7J0?dϥ }>'!b7ݎ#  3GYַLJ_e)`ך].^rcO FifNWܔ&4'W+g"K"\ɁWc[XCǺϬ@Pzq1.$!Lk`{5b _mOiPE6&7f y 67olиv/p(v\~. fzꯐ/"}_l~$7J$C_q=s-R,ZU FMSÒ@Ok$٨>Pȉo|;. {Aco9!22LNp> y!p"]lyj9hR4dT=BLuz8'A.kᚵw[H+Zhe3oQ|[="(s>g#b:caҭb,Nt %`xiYEY֪68DD5àTU6kgYmYcPy0@%14Ҟ0)A 7zǰ1d־CU vBW~rL29׸n TcK%ڐ;q9khW- Z 4 30AXKl`\2>prezuT{u:)ԸN0x"0Up ozM/gzVvd*xAU5hCqr1.@{ {a1~ :Yn+ 6PN 5&? E5Z=^ OyHnpZ%,pfȓ&UXuJo\ma^-P}ON39n ^) L0`ؖ)lh+ > ͤ@W2]K: 6ئ̌񻘶>=KNb()K8EqƱD$EN [0xqi5,rG\jQmhV5NJȚpT..'$;@8zk& _ (qG É MeIܕ?yASw>)s'K9fvQץ?Uī 1?_따xL3gy'Kw3;ɾdq5[vuB`dņ 7¦REM{Qsu. IB iAF \x5q%Pz_:;Fwڋq4zہ$_^$v緗˃IlY)PkN 5)J W~2LK| tqt BD M_aM\c*m7g bȤrv&c` ?jvㆭyEdYKEsXKULX ^(6҅+A5lYnYA5?*~m7)1%z2>>`5pTŞ$¬S:GCk&'̊/ `KЛ^qdQoi&\w=Kg+Zc<Y,&E|uIA@S hĔeLBufx:H$x;8Q m4!!QGq=2 Ro(E=z!+:*{N6[ }?*/zEGirH|]:[,[)˭'W?Ywk¶ D@~r!Z`ؘErsɿ#tUNUQ w'8sf06')-b !/L#a89#p  Dz bs'o!a1}wkXAWI$¶t#8 Q#z 19ΑPi[ :4G'i(?]J8=b#-$mΩaUd¤jXO9GXf$~O5_34`ϻ F"Ak Z{-;D ۻHh7\W gOB@ kx}=G$ A\1񷥴HCǫn1sԃdx< .!15(g|:V@Tsx}\;S=mdUŅ`65lqyK?ځv+9vl=ȅ4p>J0G{>IdNUMZhC4uh?{ ]@$sXd&YUORĮFOI$v@MƠ }ed=b04HjkLZu3 ϝc+ %~PNp05yԶeVHn wm n_6jU?t=0!Š>('doF*嶋yZݨÚvqڍ`A#Sqgkp3l.|nOYdevH6 +-7lsB F7TS~sl᰹ Qկg ƨ9v{O'*]>8s tlY7^ g }u1W|A -8TqA> \zЩ[߬}ЯjotdNC {r`Cw?t]j˿JARmAIiSN~ӡI-83No`%JQVxQ7ijԵFW‮"HȘ-RYB[]/3"[T](e4M&Dž1Rl0:1p&IjjĮz}tDqn:\K |#rg\ Jao*m|b ^LA{-ZPPa@hu{7نi?i([k{Ei9={&)?3<`c.j-5 fZgxe&_ZYNhK˲4#d,0dpCa?/iXMi n1;Xe: 3E;&Iqĸ=g֏sX rF3xۗ!Nxy$,n:jBt2T1A6y,޹ ^9C~@VJoZ'8RʩtՑLǗw,."u<ϫ j7ƠSSgzVUILWB5gv86s"rE7\3@{l+Y~7 qfWgbޖT_p b,T?Njtf,1EwV+j0>}Vb/z _`vGy`˱qg/0|Tc$Dk4Ug&Z˞ی_`˪ #S*ĽƓq/&6p1Z|0>e8ii_, zJ*o?]kA]k03l,6/f`pJ:^i:RNW\Y`y:"6-8kWaW;MQSnɃ cd!'{zaZ 4iw)S䛈hѽQk5¸vt+u0$XYa,%׍A=rʪQ> &pηm NcHI4 j$\洩G4eK%,gcOB)4;/a.>)/{׃vYX0'FcA*;Ya.o{1 .8M|wfmh#K:=\bM\,U"N_oچ3S쑱8)_N8 _lސigzRV/t3A> /GAMӏF+KOJy86kYn,y]9Ԍ6kK d|$<*^mq\.x4Х"~C:K~||3VgZS64mXy~5/VAu"!dʀȞf LacKաMpΦ<iEmiq>a<35f" +e d%-I(c~MC E@O|;!R2P8,SW尭Z(wY?ӌ pXiND6wL°,wuV|A!-zb씟@<)OnHh@،,E~,DsN;w6p( A;ۮM:ub$9:S|Uy+Mio7fX6Ȏ#T{7aZe]5צvWK㠤%) Щ9Am'# p ZƼ|-=~I:Yb"Ky_16Jn$:G9cI8b˳~-h;_7U ~In #Hץאg+3!b]r-5wr̰Pԥf6)ErW|`ʬdj汇 YVzipD՘`/ݾ~y#+{@OsKo蛝UB{%WRE<.3Ť6z!!G[&Lhn};lhyXR0ƗqW/Cfzwl'&1(|5QKh'Y~I.GO3qbϡ\NzL2 @Z6IV|S~%vTqU);QMfXc.^E-KsԖpT Sk.W]G⾓iq7hPfJE׆xaA(>6Pc^@9Vp(fO%4A39)[50V&v̈s;. X( 7.XR Y$\W-zK l /uk6GF1T[h}+R7xx;O4qNӼ%Ň(~Q_P3.eeK ۔CnM{d0( Tkʯ;ԥ_Qf [êkZZ:AIKb*``1:.RVcU$fj,$4G=bƼ|-=~#\xgFcwKy_16Jn$:~ot lpSwtuthk^~Ͽ)0qWF]K3mҳyI!2+ۚetN +LNlV,3dS1gxӠ"}9[wqj:/[^edWs\2h3s'|~y~ r NP]=Q\`fB2EG%A2 fUhR,@6L qibOn5GĹ[6qt,^ќLMxcυ ɢȷj Ɯ86UF9Z_36֥ٳ4_$ t'T48qtd4&* KMqP_|AW\yy'Nȩ117 kXX/Xۜ'.u2,LOӴ*ɮ$WIS[[#"?_j[*14@Ԁ˽G۠fED܅$՝n5K:j!XhtՍPx#@7c%&F>o*!jq.oG?8C/DY7穛>?410gɨ ^,s#OlTҀHx+qgB*ҮH3BI%sdVJ (lv \8*~inY# Kc!>BO 1BǰOcY?|duG{}FYЙQ_X 7 , 612x$byrz  DWj( I[Aگl?Sh3 l *S5@()v9(d^g"ŷvt*UCQ%0Ts qO0F(Yyg"Œؓmv2&{ʯ󰑪!y75w+nx&%HfT]1+FZ.?IZ[nf`RzqQ;KIK5N(I*yRp/V2nGKE+s(Rot7"lU{!2vc S;V5T=bLxUUz~rԵ?˜ܐ`mӒ&b:I*e5R;9K"b*<3Tj[[-`YV^>IEtcehrNܲ]h ]kփ?/\8I{{¦ammvJ<4~f j^ 1qḨLֶ[C Ϧ2_ܤ{Kf`P ? #ȑڕF0UÕ &-P,ox!i=߳Sv_?Q#AwsN)@pp9qq sWg44-jػ[t֦o/՚R)W; IgQk&G0vl3,%ӋG x0Ne`ϑ;"]I۫ ueɯT_3ථ;Inn|j .r9 nK&6n-7±D(=V, }^utPG>q_G K oXT2tJ_EUMS-45x~uz|}&)& fVfOo5r/ 8kVD]G'pk\Lt5g)6mQږu# [4qxmb>ɜ¯"{+9ח:$GgJ 0KյՆqmc4l ,/MW%G'n/6:>Qqh{eUu”q`]yF:^ Z?9442J[L"^ᡧOKYaa'G CZ?x+y LJ1v Rݮ5yIG\Xy])#uN}kvY94+g4 И"W1L&Yd ,a#1w!7|+nhOqmc U1@= ve-#s,؝ +Xݶzӑ)xF{ f56,MC Q՝*%=BfQŗU T+`ބF:;UdEz]F+-Ľъe|d^O84\M[^oC`@! *μg$^(]mg]a8y㿬hn  m?o8f!' UjKAWuP 14>aL;MO3+B2IE!nt/ɟč$P&lӟD,ێY7ŧ :@o)tY<4ym(;Ev<v4Ž bUr >c5󇽈⑸, /g;!藫]u#FNZ{Q{54KSot[j^̈uj |!2 3Q|b=):UZekil;-9l8[{9?@VktN[uGὋ=Jg>:vvUqRF A(Z0{ҰˤIfA[,Gi9cXD 0M[]SSRvqSGi#A;%l\]`nF9Tk_yi^N  ;R*:О:>^wTyJ =6qVxn~jm_/ 9񨅮*VFL1I9Sqg&fԡ$=OӮ(F8Z̓,Ji5Ǡ%rǝvSѰؠ)„#0$.ZïkjM puWl:XyڸŠB`A miNTÚ%W[&FK 39ϿoMmd|U9K2:[Q1~?n YNwHK"A@ -r (n &8 Lfu9d7QZ'^f1^yYa&Kt~yQλ:|d\n2lqc>B"!c_$zמ|Qo E:}6.4v?WQZ|Bj(tg4JvvωP rC|| ~Dot_Q%ڐ qLKpñ"rΏWjz/ջC}&v@gGN+`;" $h&*Q!"`s5+".$tkC-X gmBnPEL-d)|UMP@(QC+3Θm 15\*Rb!Q3IHhC?縱ܤ7wONΝĸ1WX㒃_IַÛ4~AF] pqkcr Fz?w{M aH?`9INr~Ʒ܋.݋s"Vӣ*7P*'|4[xs$Hç4mK٘К -?KW/mCsM5Ƌ|ԼpKoR`SPgj5bFtX|8.gf;J w]n|;'dokdz˪s 6Laxew-ݯj姲eg&C& קo,N6dQnhݮ>a 6A ]]F231G͈Err T,Y AW7!pe[jf ]%T, `ѷ6;R7fm5{57!ufK d24_7wAtB衔zIg wDQR@'b.[i4(58L94wNK`L;]Jdbm !3A96tLn``kDV4=z>qmI%cU՚R@ZR BD},(n97XŨp(*N#  zz3M?s]JW w$З7{@GG<10+fľ4ДB̀]AH=aK?x4Z56 3$aN.Y|ĝcdl".EfӴ+a4l(G`CHys K:#?)X] H!}Xԥi*(RǧO>1k>|b|]Rd˯"Kœ+%/h\42XL8ht@{@ewY3BGbzޢ)hC՘k+KlZ ^(5zܑʝх GU~Sy2Iwn$d&eK6U7k O4By F}g(Ӱm<;KO0=RCL:dK>`VgJ)xXyb PL*9kKMa*ca7Yi욑YAƓ*nܴ#;6;/dNHE,O51'OCwo~Ԗkcd{ 7w;︘"/ Y^a Wts۞d̡M(m[xCh(5s!X%b4({lu[=āg~X({㚹4[pFLIB:4zx& GY)@\v5A7gbޖ.o%=Š(=QgMXMK1|VZ+YMf>~y"^u:!9a^3 PˮϏ1fbw !)bN C3U 1=xv\`"Y9v.EI=3vMD"G^11D8hRpDB3d-q *^$ܙ wE ? @< }X-bOHW]wV\xw_'JT褰u#7fľqߵsY~(x=;o;%kgt'F#R9]U#&PJ9^uq};' њ 50 L)uvv7Eo"mM7!R9|p̄C$(cdu%QN2M;}:Gacoht( KbY/lv\rT}Q An@t -+DLU x/1% csxZsBEAP?WZy=ˈq ϏT%" 7f=/SKQ"he_`I`p_js޹C7YcX};w`(TaRt>ih*XCX'!LG$j@S?ZUgaΑFZ,PjZ>@8o>&BqqT{_YWRY ڐ,Y'HJjoASN.俨ooS]=Շ:uULcsEo >8`t\BT1`uf w1pcNBcۅ4v; 3TT9,^rVhd >j+bOWBj%z%Vozߝ7g.hٹM?<7z^å=ÝkvD]H3X%ysᣐؚ9UF85QP$vةoSn]A9sdx~/{8 ?1XtF?HX+(zc.\9ꜿGxNz?uR߼ֆLmt&F+{mq5&ްGNᚕ-讑0ZNpr i&1u <^X\ww(rsq%CW˶G cx1nkQƦ"I n.)=dF LG 89G$? +! E[l#mhNS F87iK3E@H=gh;*3͵]3IТ"Y 1,)leL08WtQU㼟TwvCb] ]b*G:+H <[j]U K%Sq6蛪SWtm 4xy!ӽ`٢UC>KkYtq@(hzN6%Q)%:w&zu%Y:B XeE̞9`+X:,VYÖlF1]Szک8W@'#wy$ݼ[eGY<~Ok8 ŇtO1 Y0Ms!Tf9/-xH3أ&i K1#O'L)9l aF"!PNYFj5̮nݱnPj6`|dhJ3GzȗTjh,c |0^W%*JmQ=A ε p硞z7/ .4]KXO6v2p 3R*٣=ˆ܇*!6kHN \; xOVWxPz0鶡xL@QM?<+"t>ߋlg[՚"kμE[ʸ+xp]>[Qxc?'abB8 yM8) fⴗ/I@?O0t5D no[3Uf`&O:k"Ji[;YʺاZ37k>(ukT k3=PͺQ Q2OL"]^ͧjz㟯bgIag7':[}1:IgDgINni5bBpqڞr'`Xg?J%L,35+6eA6@dZDpn2axzM;#CS.[eDRI7Ȓ5P+=2vu/𠿡?ڔ3ʕhך/ZpEts?!*$a6gMwjc+f5Ӛc$ pX011'1j>0g?;eVu?SU<+2))ګ=qS Na9-lRrJK1Q#2%`~B%WRIԂX e߁$w>U26 vXmDd6~k웩kŋNj :C! z]6CJ/HeSp&" UG~"@ ["=uVɑFyTNS;MN+sX"U\cb@(Ɋ:A:*2^ix]NpA<A"Q׳UXώ@3ǕSySX.Hlj3(#a-1n~EࢅLt7%;gwnM B$o6mcf´G{ _)!nwygɃEEwk/UX ܯ (B DU?|=)ٺ4@/]G%tE6U&w:ٲ2 ,2Suh+0sh˹΋ε,.}*`<+f3DZ'4JZR)  Eg8ŀLUIa_4pH񒒁ai`SLSdS5FL(+aIlZ"lJ6a.l|wD@ zNqP~3zP6HHL! ~c3VuRթ#_S@7 :E" stM M׼Zmt^ß\<=رzbt>Vʦ`kgA96c?mP6)a{6QCbͲٵʶP|fy̷&.f2y =9^YxgI!HlX^.sS7)eĝҮ@ t- J8 s)*{n 01ɢl 7_훚"R~ELXC__WqXo`LSWM|d0Ap$fʼnC۔nNX?)i=\7zB/٨5,bHNKx[oj}W!3]B]%ח޵6dfOL͞Im4eoYe8,*z)WT+e C(M~eR{a4z˝89J%iMv=m#$U ,q-6牊 -K9 wL}sC"^35O ~+[ #ށ57FbOX)St= d`+Mjf@R M=Jsi[ST= mʜ0Eb5,⇪Tй.$F6v^TZZI Rqh8g&{6P< t짃'xz2q=9U0`Q݆juJl`^iǰ~)q $(Ώ A2CfK}mp-wGs?N! U6xAba|RdjImL}KoPqѶ֋7e2.7ɳ )́QħQOj#Ȧ%f>PGzF2dմ7a`"ǼUyoPO$k;'jA#{_֐G5($9etLi6#/W:FG>vX,E૓'?a:'^Ylz1,K*ICYϱ;L\n}r{ OGjKb Vnu/C%#dZˆ$JaX8Q]Uf> 9 -S-LQ^)Hw9+_4 #s˞,M!A*A#ay!zSBR zϧu|2Cs M%p$&β0WFx z<)GqJRr@zBM TCi<<9Ǐul\oIA퇍I<ުbHpBm:,漣8c: yS"Aa8Vc2y~aVZmccx 2&M튙EY69<GOp/ۓ驶q(rh9L[U$f hfS$q~` ?6r"r*ogl}$40Qp6lWs;<2 l;*Κ(;g{TӣueLAv6,$OٞZʲֳ=Irbez4s? MFMgwL{Kv/4~gTL&$A[|_uS8Dneg8jf5 #l(q"bEٺWu?>wP>bUI5a=C S~;넾C̾sZrO 79]#ϋ3x:Y3uǿst/q,Ӹmܯ4ŤDx=^mC~ȅXF3؀ZU[~@ChC[PY2qWbAKU{Ԧ†*㒔tC ,V4s$]#MrjhWpY 8O*2kCL,M:1 #30Rw׆ҞMlm3Jb=B ؋AS 5mZw5<*7ĸTӪ$t}WfEDoE4$0)V$S z1CmL^{cLZ)HpUn7,JCN~f׭F?BB2\Th("s6u5JNs>Ծ|>,1nmM XUfyz3HpP lҋqDؽ ^рq 6'bMz%^i;KρmhyOFHTHy8u[>f)i 4C_׫ꫪclJXLjƶ# g%]_N)c,eW.oRT'2UI%tm HYJƥO9@|afC;s t3Ze:?NM-LM l3v@oMUWDmH*d+u5E;iz ϭ j`#2\j=CFd|Bvup\SYtM 1(IHLC&jiF*DP,sF֔$)NQ=ƞ̗?Y98^cepMzy2w!6}s"}ѨL? /=^AO(i@Of;[+CZ y.啙E' ֚wإu榪Ii0R%ʦp}Ty (rCv9%N:H7p养, CKL r`ꦉ2ƴX9}׫'.M//D#rD̋\Ed7QS{q X=G;9yIa~WQýtA[_TjMQUFv!_gh ➽oգ2ʰ i#h^WK)! $٠ E(uvdn6Hx/!"terOJ%ptm=GsP,C.GcèYj I'r[<uy/"-mi^kwɳ#S+Q?b-ڎ*tckqHհQYuqm^bpaiTg[\ & kNRLЂ޳gq+}&29 WB*%v19礙&~V(t%;ll ۦ)#0%S-{ H9;O-+։ߞ:m-ٛ_MϳȎ5\`%?ƽMw5ʄtTvfmPvWH`Sn5Bk8H׆>0"8F9~x,_z!gc7H7=~kIw( wMx"7~SjT_N|J4CL7̷#^jBIW]cnP ' uQ'}:߲7ƺHd1q9B[ [Wܓ tyI( Y!.~xNJ5PDt"%%ɫ5\")>+o:W/Mh==3@!fp-",5Ɏ"*?9AHm%'? @2rKgݧ/;^WvKnPV5P(4n<)f%V_24|=ޔtjK4m2K~le x*,_OZItHZw >ɢ$P.~ovK[} e쁃Ť"$e;̷7$y&!u4jnu.%~.|uo!$֎*]4CP1%6`콵`SB/K4z?Ǝlo]3!!&?垸wzA,$ߊ%(}T$8hŢT %xH 븹籝12]C_~ _LjmZo*)نMAZj"g`68PӣXeTFo"FϷzv$8]J)ͱ\K ]Z5Qȑb]*OքS&"P2׍~nټ?W-XQPnڧVڨ+/A.VX{_-9咀"QƆ"F 4d7C|ULi\ 7iE~e`6rk:k6f6ҧMK88ADGB W)QQDpkh0s*Ɔ,9)iwJgMUAfA7o6"Jj+|IK$ ^RNf$R㧂Izm<0Xeˑ!k&[T4_5s"Fe=la6TR$k;h1ApQb-xkSUR1Be± f+/،3ZMEu,y笓l|#{>:*X9[PY 9XK凱ŎVƎvRիH4f%¹j~z{Lg!1vVy 7' {`zr{Z3| uLj)kDz:R>3(1]j_V93pƬ}NO`%h|{|m^ASu*LF>5*1gT b` V hI:gq0N:80M2?IV]7z>78D]dnALǓrjXSmW3f"`v7.]JbTe tĝ2yI;!&VI%QB0B)Hv 9'1oLFf +KTB"yNO^`dp":Em!X!qITfVG7h]689rm 2r͏Qe(J˜v?"6_v씆(^ߠ!1סzk\g Q9Ǔ6(pB0ejcT6-Q,：dRG v($PGdqnA|V~3SKj Z}V)SXZcsKXA+V#_NjѿcmYF}ۻzc ={$kB8a hпm6'&ta\P}p΅c! O0q!̸[@Ѷ=R`*Aw^`d8FVz5TV68nJH=U “ h!7.=.C#EζKHZ;#ݙW1 UpadȚ%XLKhfܕрn"8RI3(DIxQdTh败KC*}4TwW0PE8r&3 hN<̎L@5GL3*:=: Hb%1u0_`TԬe Ƨ֮Aӝmj!ѷwx?] :v&ڳIJ$[cb`xo#TAn&D{! -%^ |~=~Ӎ`1bBg&`0tVׅ"H#\ݤGX967rں SI2-#psI#offb`S١q6Wcm2Nr8 sF@ 0#we2*5:cV+k [ [&2-HނRX:A[9,m9')c7RYz TCa+.A#Mx6^, Y eU}Nx+2 N+<6%ŏH8*j adm@zT:)&3Eog'Km6V fweVUŖ52LW#SA߽a *qq[`yQGE&owmpDD],`IQN%VEK,y'hhT=۴k X65UQH\]ʦ1evV6<օ% OY8e@(*,a$:ՑNSp,N=Eȏ :oZ/Jg\r1\NM#9Jﶯ/#>Fhhj5wb0@NM4SfT*]NÌT#(.D0`F$2 & U^6q j<Hqʱ#5ؼUĉ=1nM5ѡh>4SbXR. E1(X2KAF?z2,bۚ Lbٱ4oT|#y3QԊn&)!@kh6^q? kl~kcOEq7|`K )RS!>"2a.3-λ Iiw#,U2dL`uh )v 3^^(4xW_*VZb`#ҳ鮐{B. 3CN<W(p_Y\o%;BvLww1>Ͻ1;H<죎y^xd~;_-Iv6p?ZA g^Had&=ڎ6݅z,'3qvSSz%R!56r3QbRbX b ,fJ5zk# ,'.fleyLTJ:)Pm@M}45(p׶0flX9$\\mfC9 P(8" zQ3ۂa֣ ߽`KzV~2Ĕ8ͮ$`Qʼnx}8@-b(h"V 8{-2nQ^!E}f^/eHFgl7ளbg 0,RmP:nPZb^' A(3)q3yRFLr,oj! @xw@(q "& g `;ek}\[:M!?/3!)(nN9,j%}y:ϸx3+h3g;9'h0|6w71ӄu6CA,*HZG'g+jD曀 ye(K:bϧ:".v =_O?%\X53jo+{fYy3Dx h,',]V' ,1n) X΃TӆH- 4;1Mx67U8+"Ӥ.W&jPޡkxWS8kqW9=(4Bլ5E"65&9yP6 D] qьܟyaߴCAZa >u7PCuW?"׋ur1A7p]5 v@qzQ > .Js|oQi/Zd~ys=o`\oPD/usxg^esc'u,Tc Ƈz}D GtmgHJj{n(Ug @[V3~HKeSR:`˜ "VCD|fg<C>%'K[3(.KH!qQ;wl)s9+o3/ ɾKA>b:Ћ BbBKfjra A(^Ted^T':3{gi7{_o)V|yqD{Mo_y"M7wx7DpbNyx_}_"o,7y箶i}˟b|3ϋ/~S8#>7{b{a{wx5.ܽdYTX`<'>Am,lqFM@mγBۖ<-k^lcy \tCsi`DP0tD6垥gE6 B Z+ Rɥ{P$nb1;[ƒ h6(%mtA/ 8t|aLjn+58S걘PZt4\aH(SXA[N^(\mj SG!c6*ƚ; <sm]RA%h9˜y?aY.\3 xcUQ\z: 2D Adn}޸fwKpO(bYL"*͋Jab eۢ4ʯJOf7g_򁨳g=(ѐU$WD1.rP]5dC6C.m pnwS Q@7,L6Du )Tk44nl LXuAu 3l=ޓcB8cyݳUwV1bG )>Ս^Sz;9j)g"T\$fPWa8 70y!J%lGra%?3DL\i4^?~K ᪭k'޳oO}x.+L|0/K8,OOfo~o9CєWem ); ~=,gMX&@ǠS=\24o;BrOH &/*!(UrX"V# |'Ob%kldB$UHA,^O(,v@۳K,O4Dmְ-Ԛר9Pa u&9mP^wDeKj'7Q`MQʨ^p.J&]JpkY@0 2 $oKE5Py`I]ܕ2TG é1Dtn,=ݟ'm53ݏ0Gy]V?#ľ\9Wjw^<<&uY2-2K:gW:ёfFa(Mk`"1DqoDHlF>yb=|SCt*n@ct33}I-kX<3򩿕 .Ĭ1pDb@?~uD ~b}(&_J$hI)#<İaU6Doku*-d;/M='ύ BZ!ˍb8ͺRdi,>.tw 7Ҿ<׭1)ŻPP`_fV>#RSIHe4H;L"LA>P_@\DBP4Q Ea rF*7֪TR`_\8 u;z*uO 9;PUQ8ޤ-}J;(2;4ZBAvo ʪ׬ PWNcuV0 ]@ Z(~kD׉[qb}X~b>#o]uunhӻe'njCN[[z|#ry7x[, (=p&Z]9qg\Wؔen)$ ΐM4r1))^xʸB~*tj[ d pEB̂RBQp"H_g A4ENi6nb[fl`>Tspc ^sMOGڋv9ǜw`f^ձK Bb@cx==K,~^?%9\]e.`H3YT*{֯ы*}(Rm%sC#0J>iKKndLr\X2=KSz=M!š]WA{h!@7A]_ R-,xK;xDp #+R֙HN *x'6CX!ש~t;Ug XӃ UIv*5#.4o0{;tG5fkH-;^%f7F,D5G:-[yZBfsgXksK9fx mET@v۷YTYEzgA2$@#y$62Z,"ٱ֟RvX8BN&=*ͲHIhkZ( +5&CVa0ʡt"Ds2Vī#W:X,>E5BVsTY+U*=B) f/GS3]q'kl>seʻ [Zv6i9 ULK]Jܹ7ŖKѪ X3Nuev 4RExߏ}DB'7T.yK! _pXΗDwP9Π0Oe@Eً_e+u*է]a1d?qI{ L w~`窸o^i&/M0@)T,qIhAHmy,~z֟?ҳ_^۫p2i*h~z4kѩw(3!+D<,0i%|NMiȮTSt 1g5C%(CϫIX%g9J?qaY`mG$;ES 556~ճ'W_.]:u~!HT0S^N[BReW?,k/]U#[Rڹ-!fL @na)C#<-R<9 fQ66Lu(PiEz%vߔ'XhVr gkzdƥSHITFD~$G8ceחWG0)B`?hYZgڿF_u^OD=GGZj0W*$9ڢ%C@1|З%cf&}YexGxeS#̫- T%|p* @|]謤j}73|4sψWʆ.J.sSfg2XGRǸsByf`VMmĠm0ЈՑd}b:E:aUj/ͦI4DJM #"P5.襪(3[*.nU"0,^KtIL[ae=* f5ԾqǜWo҆"xnc`a߈)|ǃ-oY&; (RW0}MnMٯ9/ N\!D.cu?e@vPђ1mԿzӒ̭L1Z]isݾx2s vS<(|u?qeq;n~~_Y#|*5h-*>7nj׀rmt G,+uK_aĽ=,%bhfgk!8>>3Fs)R e $+% cVM>Hixvi PEucSX1yr8~JۯڶqC+D(6 .ɡ;GK8YB zgq.R؞uvǥg da*%4ű! ?!.sf (n V Ӓ0B=@v~`[i7qs?2+TOQ$wifflJO:4xLhRA-YOJћ@t( 6D.Yo7T,n_Df022xP |L^7!lf?|rV e#EtO$~!2-xHﺇE*Ä`R=|h13\0 lWIr%;)ݡ"_m2]A` U@GA&t=6p Ad'S:6EmN{=!ATCsq ڦb&ykk&EFߑ</qcAe'"\y{RU4* chLf>~TPSuwd8f7ׅ쌯{Bpspd>R+ndםcq<\<&ujOUz WZ4kq]3] vv#JDX gܮ=羃>S jv7 Rwa(bO gQl_V )sس_/8n2 Ljdiq* fm)NKy #Fs\oК=Gnt~NcJ@yM\p9$Y0d=e6a!:Y.9Jsv',C6eă" D %ɺ`.h VRIӀIS"!S`cJ(羰ز 7- LC //e #ΟHRPbԹ`c`"AGߢ!c /2M_жZIPpHʞ`39Q:tQ (bCT |+ؚl+!TQY3%s}<^w~+qn~c<8T1` ?Idz\Ɣuf7T66H¯zt*/5` 5]sAzw6%<9 ׅ`>(W1B&׊ n_Ʊߪ5%Q^rr׆zuw#w_;4W:Ǹ:ڐJa{4O8Ѧk'M51I%9Tv~)ZCP!_|Nc tLIӃ}=wsZ4}3kTHuh*a1#d:w2f>9L"{J. 1ct Y]@<l҄{1WdXd,߷᷶FDEx6jA=!>jJfCoC[%Ԁ<]RZ jw>c|:??h>B2L48^0wEa$ywf}SvNW`r13wsۯG󌃖?gGtI$~o2j^U$.5`5wN+QQ֮:da(Ͱf2`…x@^\.F`tᱏ2d’'~_8lY=RW#=b|[Q^oͨOXrxg8J[E9:!E }kxxam0].4D>ؕYxD,̳̍$eRwnJ7(g4Q*Ez*\f*kMsG د8C>R{e&E0_ kr0+;8?l?G]csw6jָ_S58kU~:W< W!Ҩ-Ss lgc1)5)]V<8jIP/ I/,]y<\Ѽj!}!YV='MU?p'gQ-*/ܠр~:|, Ѐycdi/6Z7ۨzn .gkO0bXԯ . C l{̚ٷ.qqZ&ߒ0{bRגSrF~*cHa_N):亱/rM Ֆ{epQEQBP%9 5'sJwU4hUvuo¿޷2q/":w1 Sn`+ h-ly(F:oh)*i 7dWӚ0BZ-C,zQj>Sn8{!7Tl1E*t=6 ~A6slBZ0k)]Lb\tIqH5(ͭnd_ɚn;hCaF:H< p̽2ZƎVؿф;u ރ#2ɪ4`-1xf̗*8LEc ?:-)gNӿiDŽG]&F?Y*,*~oҰ)uJ vu$EYÅ'?|6سjZŒ{b/N4}QBQFR.N'6nOA*y}f, 7'Ƈ2#~Ȼ !!R ֕ɡA 0 _b~$Ir;\`(sl| ̪otP$~*MNȪv\@a(|"\ a9Wc◍֘5SzRuw)(7gBU0Pl1Z\6G(6UT9*:=T WnTyr4HӅ!XJ=L[ SA8BMl`H5|@n"F =@W; Ru3AUi RvY~z+VeG2bQqy}!s:50I¿DL`=FJ#Fz8;$c{h}xAo [xJ,mZLj7zi:Z ^'_IIsDgHNnĕn^r[ ҾP+lz |vZi'4(Dh5oX#G(,5FX#،BY|CL01BSy=Dx{ʹcTF"faQUۺd?oP]:<U8 ^r MW{3BlnsϋVme2B#PATl>$l\]īlm.fa譒vv4M$!=EM r^Hz e tpWVR5Ў?.Dgj~uL[IK4]+tm!vwi:|泟Mcd`K̀Zur%SeLQv!mIt\8V[Ų`PÑ6׫Ð@t $+ (caw cop3|+%oS++DSa@H+\Ʊ #Bb9(ɕeShx3;mpgm(YƤAC:@˷r{`JhvyG7JʣLZ/1zr/U~F9b+!<EΕç,8.-|žOYb]Wٌ)L?m 㖙 ^9|b> q|EjfSو, ]gLUE,=T5D']O.x. 7K'SC..ñڇID?^r Y~R6T"EǢCHn/9.&;5.cļcb>>Ff>Gы*2^*s HQvMqH/*u8Yt߭vv q̯uNKt#qsi}oi^_AS)4?\`ؗXjC'Ãyr=:yAr~7.JGu4qͻ'LD^`^ZVks ' M4"1gp7R2ృ5rII,%"#ͫ@5fQ)wnrj΋xcKgv7"g⡞cKkP]126&D6ش(CϮ:󙘑G߮+q) ̭]Jܥ(6:@;_eЍF[~gGkF~~hurw?>;yE(vOQt Gn_:ˉ3GDRua1G*^}ّgJ D^vȰC /=1=J4p `0/OU~|N +z{;p;g䃳Z99frЫnF\H20pqh9sZB4˃B.wWd2?C]G{nwl놟#VuNtuG:WKr%7 DQ<¹6l73ZγLL`.M9:3" =tD l5Xqc Guޥy22OYLFl{ę-8Chwd56y_JQ0$Z0j⧷v<-|6Uc$vp cu 쁽mY1 A6h8d@Nw҄>neZ%;Vɂ^m;+ ֺulT1@ȠǵN4R" }LN2w;`XW0qͺlqB s_nbį @ϷĉV\xZeyR'`W/>-僃cr~+'_e#G&&AS1\w(Ϸ#\3i 3[A΀l{qJB&YАP"lu>ye͕T$^ú^z%4NҺza%+`,FZlˮymEyQh1ywrSt3A +^gNgc~ny83FC&!=0ǍqmM{[pYbj8%BydE\ o[ti CmkaFP Sw8?dvw)̉`3dܗ8"LD@ER$ zjuKPr4lr8rm ӗ7ȫ 2.q~7#y/!4KcvIã62*Y< W2RܚSo\;0m=U #gX,uTtZH06W dPpϣtwd*"2zMVc[صzd5ac(?N)Z| E$k"qbO^`ivG.X*i?E;Д ^[ ܰO2]Bg ĭa|=4x} _Ii' Bkq,8˔/dz$^;Me…$2\;FQ)9a R73t~AcC.zALwVL`+ƇYTdF(;a[5z7ٺMi_buϐ39qS8ئzha&-Y'Ƽ^Z:D IhSzwuX5kR7Nz01ٔ9sʣfX**mS Վں&qU4GY9pqA\0D@ELQe%b !|iɼLAWch_$Y=G!CFq(0x`&)NOi쁩": W-wfن~ |%P/tFH3l\CȐml($f t"Yh֜)=tmktgjٕȡh  pI*&fRݖ?Dk&J (MmR~?E 8ɇKcC٠${H/FK@-bX2r2.7ǰVNCF̊!<ߴXܪX bp-NEŵޔ]od` )bd o\uciƒnߤWJFˀf9Ny8{7ׯ.84DTKX]BG"~OLＢd7Wxdh ?^dH~{}uޱ˒3C.o˔+p\3;_8a;IDu,/AWsLEBhGe3Rp, e=!"*fbΎqz՚tj 򌚈#_/x]jb~r(fngb[p24M,Z uҤnMVvuNܘc)|(#@% WK, }~%wkFYU<~zӝQDQk;7΂Nmv'W\iVS-;f(S$d*e;NvhgZml.;IDcfW<f" Ra@=u °mo6\< zBҟO=Ъ-Q,2q yi40%J׵Q$Pkk'JGd5K @q!átT *iSҌ[]:=`S&9qV"a5s}O-ɉ!:GcQA@:'kvE7>a["](~+vnGײls9@zwsD(У}]|YLꋊ@Vr &ǂ^ӹ4͏zUBsԲN?gk-ܺY ڣIzȷܐZ9}tvc?x-vx o4m3]c`mSVfum4(T :>q1'^!VsVI;G۔qڢDNZ{h񦰬[80_K1+76̃qy }enUӳJ![21($\N5Ka77r&4QΗe}(DY&4QΗrDst9QyDɜrL7LyeMuQ`馥>5F}Ag.R) sd2LqזF-D0t*dal= `ʡBg^`2<ܚņFvTF>'HEG~5+Ac*[R85EHf>=o` -xѷ0OSI`uGE1*DR0`?*?H&G&x|`| w2l i0qd^C,#*KiN~B>2I#f'r35̹^Ea}D#fwJࣿ\Zs/U=}M ?>}aW7O&=k!򪳽>aaq|63 ~=ނ<^@.4'P9R4Vغ56t*uJɺˆObƃ6H~.u짫ڳ 9wM | gk6=UO>􅭣>/fcAhH6IcwU' 5AHj+'/wgk%z$rhtb))}`Ȇm`@\yT=+J{jkVE^HM5 r q=`CT:B0-2c.kMmn"ߤJSm'rcmqhwR7y+$ E>n8fΏBbZ-I*_* #coS~Ź.T^rJC5UFeOgsq0?/5Vd9jt0,!T@pu ,lq8NLvk k[q}Ӊ08?7ֲ2.L> D= ^?NFc|˥1Ag4)S`Zz6'w&:c'Ǥ+/sQ-zo&sRq6Tk6OI8;ZmOd2" SeZR 'QVdFU}1⛵#&-xf;ѱUB[~b2X\*tvKY=$Մі;nà6Xa/ʍ)NzѼnK Mv=#+ss6&cB5 mF+^Ų&:5$ Bj. /{N&\/=M D=9;‚ ën~=BuX: \^MuZϗ#wg^& ?r.n}nVψ3"&#pxAZcKW.?E fտl_AY1B*Ph~ aHFc}A?SnQ 60Oʞ|pQJw`ET5]Q諐)3?8b-TkqZJzb!bݳUZ3+2B*:ip6M%/s\+LJo47hms lV( }h6dƿΞ>{ջXXLҙ-`#+>WGu~YU^dFR]5j/Rk-rs1-/ q.k\y]u"Bamѕל%YC_=ql TB $`Ї؀ͬmio~7b\~LhH5Nkty;NLݝ,̲L Av_(1|+ۮJ0jIFA0v 9ӻ&T“aal3)2_ b0NskIO]V˅MyT+/Qb sObtÔ+7toΊ1ӘѠA8& u + }h~#@@I#_$AR03oCњ6 "Gݓ/β5_Hw+ }28=8~=Gper 7?NKɁ\],D\{7j]kfE^HU? چ7Ca5q]@鍚mNՁ`VAF/lLiwzתwԪ]<2suQgɣQSdd (!Rޗt" 5wanqf"\GZ&%>dGWAk$' nP?|,w3ⴺ5ךjAg `L ]UB!?!qM;.xX)kBcY1291VfiNf.Q6 k?E;W +QDT^z-)9͖0_>̯A7h֝Qci#Io8WÙ. +&k:E#@=]mroO=O;(lj Wr|}g.O{?*qci2w7ywֽWem>;L^i9$[ڞҶ>88]^}4 i*Q5}n^ce> v^|> gιvae5NХg nsRaiL;{ 5$kcZ$Yq/e.{3_"lY ˵K٦t/Sszh5e u|w%G56u~ʐhZ?rfl(>jlJb .4ܨ/4WƠD%# QiP9P ISyV@j* K-XVB 86Pi)5Ǽ\B|'%۱Y@q8s*FFV{9&=(MZ=Y\b8;֎?I4ȴ|_ l(1[&eUݣfQ$avLn3@44Zڰguټ[痐rB4\@ lF41d/mNt/ߕ|(^6=w=Nt70$H! 07ԙ9oґ;*yTT.zaȤZ4:8X4=scB$QJ'J4ɼBӘn$}s(#ҕ#LY+Kez$ {:\ kR"=%L/cOkh[a!LWfc"&PM)*ymc>E5>KM&UCkSZA2cRbd9\BhL5]js2ci#~m^w|nubREi{n;Gzh✑ѳ|ϗ--#>JGV0V(LcD) W6^a9nݗG jgbBR7S}YVBQ nk L?!Ha(qm͔YBPl[!-Of͢ w&ndV)MD P6Sf*iYla6:1zCQfI B 1020kP/yc6Vwa5QbTWKڒ2Bu\%[nl*qreQb&;Y\o1%FFQa'c`m }RIuզݠVm?_CnfSpBZb'zE­s!, JϟwL^̜ ƿu#m67ekMpٖLOo%"J~w2Y3Gy|2&0ٞF܈k5WjF@tCUWZ:FXh]`&JgEC{2 /4>C) ޓ@̲j%wܦΤ^Dhq^N<= 7ͤKk\O Jǵ ]]>W<9G3}M:)I :!9Ն99B !*षu TthmsAIDLa09~*:!iv{]@+8Ҳj%Lv4Pj,pJ#*93[uinҙ| CB$ElŁT̿s@jRf05Y!0䱸|MqB:C4H"*|ahߢ1ִJ1\wn;8s@~]I豑 <8I#ѼN;`&NKnsg! { 7e8kVE^G/WMcs)&rLt@DJG(J0Ff 0 _*~l.sIt|o0ys՛\O3W\MOcX8YQi =^DCP lsEf%XupHIJ#1\LSad RŬ98" έ F#2 |d`|<W\HAKZ/g#08.SWɡV`xIq<, 5G XFֆ9cŲa,G6.mPZ|e2TAu:Q:@)}Ň03 SǎRܔC G7v#Fo,Cu,K-5PLåjGcMnDJ2q* +5@9P:(&Zuso#5GF8ܤ)<X6@Ҳ^@GE"T MDAУ -eKGQSfgFYQ`r,4Hܗȃ0L k _-٭8l+@z4iU.;~,T%|I IX0cdFz5_Ӫ\v0AVmU|XhTU$LPꛒny,!EQQZaf!{`:BKɇ L_pr2i~ׅA!^9iJ-_Zxh|d ;ʮ8TCS7rDӦ0 Lf `fu_JJ jk_V]hQ_j]'_C8mid΁ru*$Mޞ@RiR[,vh6B~?$>0ӔĽ*c2Pfa滑,hzXr83*EzH]XCpߥH]GygC`7#O^)Ǜ_,tc6Kr1o"U:Fĸy&fka6,<>L8"/u~.51fyK۫@WC>E_s)E]_UK-t*C{۩*b\;Hp::TY9TWbY/.1%¨Y5ۖq5A$} wr%ef'`u#Əj^C6u"\;2O#oX2C/*GTcNrL|G301ܗZXZ`&e"w-4N(|g(h**ag'm]vh79SqK}?[5 ZAyWsG[^XH[[g B%34iNPAlR*Cp2OJRyj -1 yD`ώ WW7dP'bznlUK)%@ITF؝ WGc=:jx#Ԝ%uTg2$47*<R7FQ7 d.^Bъ֥гRFrz}qC1]TfK=} oQ -f]|eGO!H''SʡǠ* {N>ZFxh>K}) J Δ5 ZQ5B郸Nq&;sFغ=K4mI*ao]i+P~ʏ({[> 1Zݢv"BU%cZW&G3&nLt(6P|Ol/Ŝ $Hvtd F'06 {͔M7\NNR. U!U0UJ8Q8<bPSOL­8PD~Sy+6[(ȅ㢦N-Qo@(6x Iq]вqkMoM'9 aR%]{&1>I5UnTEdKqS*pJjF/# Ρ,D4Y)[c3B5[Ơ;0UZךr2v`PW!JE⊫U.^dj2VAy2>`/>🌤&IDk~H}^ðZxF4 '-h}HCusN5[O? >M>5 򈑴 h#'u,FkZV:ǐG whLwD_Bl0TMVhJXu\*Y*"BplۚtHP[Ԥ08B$:/ֶS$;8+6̦><|B|MFS"wR1#|jqV\(KWUa"b 1]V%vafO:yƟ@`@bm8OsUyf i+Fֵ;2wjPw3+˴[*ES\t>\ zl B4ǢOEh =E`|b 2^L<lvAi|6fQ]cG\ hwF%Akw #mhռԠr4jjm.3`+JGq?PJrL ߬~qF#LJ&1l/c`\XEׅϥćB]`\;^XFқtʉ=m=etL\=Hd9Mc> V&L^F#nR1MTnD$FX 1:xthU#Q_F P%'eLGϪ$5G6z)#;nxp>OV.K7j}d;(rP~ PwC1S]BpjɎ$aW$uu7v #$@0km nM>|TYΜ w~K偯y|7Bg6'2YQ?jۨc:j!k} gXg rCQhH1Blǚl]oQ@@caʼn L17F@bp@v]ظt u=QL[/AJmʯxx8/TJhiN) m~؇7c" ')JO%umbVd = f02N}M Sqb;"ヹ`wpP_zEXys$e __]W)Uq^9Zr0ULJiW='3w*܎<.@RkՖIɲ]* }[}h DS@[vVY R?5.A7?t '@Tk()V}aF\/ 4gQl,hnPrH^BR RS>AnqGS6wUVFTUvɊ̽l~K֔eu2N 7Z~Ko[V@G@u`X/3N?.e@*f 8 9A7u,䎜Q=՚[ۺZuS;iCAq^cS3g)DXc5MP/l_eG ֤Gu/ڹj(E/ Gui\jmj0_>TAw>Ib_ZܟV~w;M]oC% 5݀^u5(pƆO[YŹ(v̧0(B'6#ؽ͙S ]j辵l;bBZ;;牾ԴX[&]Zם O m~pG#m?!'C{M9Q1!)?P9!|RనQ8Ԁ5(Qc, {F.#O*6+<5MTveɋl9 ݦZeio?Ԑ*v\*7?qetl0Oa a1T7صgB cG҆4Ƌ3Ɣ\ѱTS^c!GFk&48E0CAD(f1l.9t, rP0вκ::ǐ P]Ew1IHO㣐%rt%Ig=ȑ3&>1T!PuM&HMi.eZcS]!J!ftlR67ɊNA1v)-F@Ͻdžb; jS^T} hvikC|L:ƤXKOB9kMbnS*Q: g2S31-G'#v|=axn"/ʿ0O- u,!7Tܬ;ܴǜGhr@L  LwT`|烳"Tz^uj+Ye|)4rBG=Zwv1X5TC]'L) {7j)l;՘x/|0fȨv/, A~ƹl.$FW6~ ,k(:7~mGړNuU6q-?^:uj% TR`0(]{P6hVC3OЗX(lpZ/Qg,?x_*^6 sቶʠ3ȡ9xSͥ%Ec6քܻA0G/6#B7SdEW7kl+hz^_YF㺇3`V}!,:!vأtF {r,XDe\㗮97l JwaCW9r$I > EdYo/0%k(b%`^D)'KU&@YY70 8TMC[vn+`JS52g҇~[Lǎ,BKRb<$ d AD b1A{|UJ7{Ƞ%De&vЉ $ʥ.QcD|oSG1]WT9ksZb0RL 5/%Yo#cMRp1`tL L{&mIU.K!4`8Ez\~8 N }{^ Q񍱱4=fi Q^7$},AgNRAlZL%Z'^82c[ڽƼz }fb3=lj3"j/$ ÉTMWw.#Nb70 KPMF=-Ꮯ1QNZxΞn'_uyEz?k9 |]kQ=s;3ף`;ate`)KJHx+̿va>8~(T׮ܐT'MɬGG>q}B0\x}v}!j%]&Uz]x?Ԗ 3+kĝ-oX[P_{MKnQ Q ]nLYW"Tp/ 5DNS:wflrtS22uڅikփXh/eoiW^ sR|]VLSO &gOn [Cr{2 &jA$\iiZai ] $PX|p̄HdkjSm_JS/~cbAe0idSZ^]foV>6q=p^$q)rI8r/>B(BSveUw1_U=[%[qpNE0]M={zG )2>7B+ONthVy]eu$K⦪WnsT‚/ݩ&Fy=>!R㕯N 9qk^8ޏr?6QѾgGlS'>:EO#Og }ӑDL3;or jZ>>0n7^88 7N1AIrpӈC~ll =.4h;z 7 uIpr 4񍱱\23#%D xJdxtI>tC]Mgk%z$282. gG㠮3R@.Rѫ9s*B"HjɎ$aWOE}n MTd:eUlDR?p.ܹ/wXlY }XC$͍M$zJJ`V1MZ衻nF?y{hʆ!P1P'tpB)*8<~7VC^`g*X~lTbg )ֹԭI۵L`sRq}2)^ӊGD oB|!\7.ŵ& @yx딅VsMk۸ 3Zzt5vMOaj'<"}>M>]ws?֕Jnz_VcJ4edâŬDvY|ښQ_IޮS J}Ta[NVDbr1ٝ~ 71SuwKC<@Pd| :|/?nVs8k,NDXe(75OH9" gDqG!Mkv{{(@Re޵4{h3Eni*z>PTtٞ~P6M-) /} eme)[B)YyŸF#,hajy8)*"]hVBXp`77嬤6$ "$K/v}#NĆY@]֑n'G=)E5F` K㓠QL@z/e(4x4%Ƒҕ^ Tc\vy mOf*ÂJ Q"2%[Y*(^K.ˣCLijXf;g`g >1so9W^<ʶ:%jk{~JC kkg>H v pĭ#u`!9f`TCB7ʺ] ɺdɺξ|6{A#P{.!&A(J!=LlYb%1޴뙾3EfH pUEȜ> s3s fƤ\?Z#F4q|Pz"0fI.!ⷑRxRm g'EXP!$cp%0~)Sj1BĘhmR~%SE|A|Nϴ3\+R &G:5)k 6 +NAgͮ{JMNMjv m%|qcQ-eȊhcb:D``"YVU8+#zJmXlꆪj=Qx _'uv}TtQe(4VE1cL=% cjd.>׆s7 f#<2 :,TˏM1إfqT8"4QQ 5O0"uQbs"qB^U"`H?C%<= ^!ohZ&ǵm܅B`Iިb6mQƆ#G*1V٧ 5@'Sv^DP/bM~)@e>Ԇ0ǛlRU#yaK[0AmaeYt;ǫC>-cpl̳CMU:pđ {e_T^bU9ex5c 6󧽿DvYFgщW8D[紜 POQmKU62MVG[jG$7b/%t6Ty_l| P3C~] o|am}'b>ʗZndtoyںG5]1%5SfzƦ/3@aQbVW2RBSz]:_c¹Q)܏c!+ Ӥirͽ 79SuwK Mg eN[n0Bzi}3OYs1_fqX}ksfec w&s)l ,Ph(2Dv>OEw7FfF8=)+b<&8~60Mj[!F 20FхtnH_7Jߵ{hBŞlOA@q|Ɍd h I~&*8YU{z1 {jx-C5I',ٶ.ɷ9Cڽ55tg`<!x!ӂل^~Z.S{"fgr_x -():!~zBF6/rLgr0}!_>>~ӠǙ:c#W'M,*b\~qVރ")jg %vj}RNRXxMrk}JtHduPA$V~ފ;ho 5IzqlKB'=/nbu2j2ɾN$*O9M N/-7b!0kсںAt>F;JorT{D|Rm|>]T,7aX~np?RuܑJzp#/!Z-3B `ʧq_]8%-MxtnNZ'FqwT$G^F a@ qZBVjaό6[PUs4ΏKG̈́jY!:Xik4_û+ur0/JiQ)t}=eRT8#]aMV"bH*Ǡ1ƣka}XI6乇.1ecF[+"-Y`ؐvXo'@ߓ\# 5.-iUI}UL*혚bZ|Fmn>S8בUJW|&0z2Jx+nuR<Ñ]TGUa,..7aL4wfBhނ{T5[Gb= k׸3.@3w덃/iΧ;#PWD~ xN '%!h8E#YEh e/qj$Ӄ3"ex3Cf*[΁vu^~\/Jduуoz\ѝ#',PÏRZՊlʔW24{ܨy+@r^Q7,,I7C & [U'v?JLg뤂I+P P0rw wvڑh2>n0~(~[aNfEڶ 8Iׅj lWhDY}H;FrM \,;eSOV7~z0vnjEψ~+Z,|ڤ 'U3{>o|!}iky~!WBpO? g );uKS~ehJ\\KaΓu@g)Y;ӻFuz _sEU*vΝ:*ݝ@TG l{gwvdk:Q$8Hiv v/i B*4x(ڕ8ۄ*{Ʉv -pIKZ42SHʘ rHڲ6J6ҖE(n7κ!#){عcoo:M3D\"'ˆ뇀'aMJw<(Gb0pSkl_bitێ_­r1-ĺʁC9;!>Xo~1d;}X-,\wALȵfc?UY̙w4- 1ԲJ/Hj k 6םf5Z-A|ľN93k3]X4'fI9YB'PʂmLХB*+\0HSB{m\cp8SN+Ŭ>Bΐ %7CMo%?ﴦitp"˛41VeXn* E^]Q=mJ+FU> NL䠫MW^3)Rtd>zlun" UC6wףƛ ^#*?3B0C0t\iTM-#AoADZϹwZPNX6LqHrAZhlB۔иI/}Ă(JV'")`Ĉ<\% f4? +'6ClZZQ\;.|uKv730M ' ̒fhH/$7NU섆ԀЛh<"q4dK& 25XRcF6?ЩX\:62@ZKخPizH݄0U0(~<*%LC }"< -&i[FxX&G$$ƸPWZ(G_RI@ ҇v15& Gxҿxmʟq2?)tڿIapRu2);' xi`8׌Z$E&J5/+m'㬭M(6sFC!yBr?[JDḖ=Wz |SnU`Cs2@3*㋟U)T ߞ+v9Qa>qΖ,ɽOlƲFe0SZѭFiJ͓qailf)nͯk.'[I\LwAo!vӧlTa]8(q?OfJ55A' `$dU\'lai-^v+btkІQZ^2lT-ԍO#HJ+"AJr73.(hͿRP:yi}O!$ ̓A!g5"yyhdhҐG0JEa b@}K (jkGh&$T ':u>A.K3G y EOAjd!:OfGVΚHJ,m]al oIwE&uvn; lq9vcj?=H zRks]ؚ˯)agr|ԕ܃׫K8H4$7#5AZiM$+͜H7d8ih f_M Co\6d撫i8XlHe+lGB Rh,5yݙܢLYBj ũRau(&UTbt" 䏙9Pս|bewgMFƂCl3-h#nV[.[3QH0zK1 j^zf::r}vҙ T-qe^n$ջ[>0V[Q('{ÿ`43 Q{@|Gh9k4;}şO3;f> ʞSQAG 1ց*@{EKP'jq$y#C|GwG1C%3laG[TҋjbhTIp%21NM* +§2MA$n ;aʑ㸡hSday8-@3SJAwyK E] UPOYXb:D>า,+dRMvDk=1Oe Um>9#/iUCk\QpqyIl-`Dq2!v~HpT`JgmwGP,.7 N@ՋAly%ZjI'|uvJt ibQQ:Q,β~m_htJ1"bE%L!` W: ~8!~=D&ȅS'O՜zLoIflZ{m~~r-ʰD FLw@+!~ɠ6ۙS?@}"hĮ4tJ(I Z^CJSʥm: 6()r 0 tvo PTkީïYߞ#lVsa۰77qE6,S&sѼ4xf̺0kIwT$˙/8E >RwTt F)/e^pvhOq|L2 ڟ3|D ̯ǎa1AhTrR ;{b-z8I&C'Ra_M=?OH=Uo,GHµ(lxyȰ^ꩊJ݁MXգYjf8@`'^+cECݩsz[¦aCrAyLn\/}M<` >p*#QǑ 7ԲCb7-d=P4؁NM^Ly>AxBBnBϳ!;+ʗ0O,o|^I"DD\t?7sqB>s3fXqp^8;GeԙjajLx4. u-AQL0OO K^ S;`{o%PajkMoK4'u%|fVzh$.{ DBUpZ^ct͇&|Ƚ׳͹kw(.Do1~}M|ӽ5}}K^Lx Is\eX|99(`oJbv^("rE_BݛGK*N'#CƲg%9iԻ4͎5fNiyá!E& 3ZXgAۉɎShSIb\LlHzGY YN2T1C$k)br{||Y~Wu{\{| CqJrWdFS "B5u$a`ZIh@Pf`jSuk$Q%1Fׂd0dH!(uMU*hCyS@- CnRZ$|} Obޭ.ԲtzX7szZjTt!JXU"jSkB ز8,eHCf "enq/gt4fW%X +db$ۋd578/H7{}=SXϡ~{@7$X}P`="xqyJ cBuL^aaEcg*V6cOo#F%I'&g5둄;,B]=%uBHeCV/~w{e_W(әoK.#V73tB8fD&&0]B_NCXV$rhԮXPz2iPlF 9}AO* ߾mݗ⸙$wYrJ>Cg_{L bϡ_@j-BdhlkV<Z0)TUDh\P%r@)ǗG;3Ե$ p(p^DS\e])n R!XScmκ_E?ml/(?b?OB9aΖ鎸1N b1U;>9%Oƚ^)JV&&ԒGZG*° $ݨf>pENe>8NYfs۱n ٨}5t 'gQX,OJilN\Z,7Ƅʸh)hp71}L0ݤɛ&f%m-$!Y/Lu$l?O{PEZԃvCޯھs~/e -uć#{)]Dx4R?7!]wWe!&l:i\aOӕf.=XP;#40?-$3J\KΌ:}136X:5A-Oࢽ  DHz5￨)G>&jf)^ElcY*z2*eƦwvX@5W?1u7Pi-Pk^e1օkeO X"K+wʈ16PO$Ĭ6TdDPXdpU3Zh'_8dDlp"m/eK+kI ,`2B8cӏﷸ`؇= Iw #`O,ZPO(Z]yOF(,vT T͓"85֛ńR}Y6`K&emC͒iB$Aɜ3Xpأ4zvgwz 9g1Z,LFt{8y7([ F-D4JMD?^djfESFŃSϥ􍇳E,>mV|^UUVBt'* o4O dTnaF]1-tXC#Qt4V><)YBØޥCU K]Lf6= Ki(0 RzNg¯ǵ~f:" -:ax`<۷kiBݴ]ä'O[pN葻(В3Ϩ⦮Vq 0*^?>pZKm!$#T"f-@vwg1|ޏ4zfԽ-\mq8"92c^e?c5p"n5&_) "x5Pԑ iCwƨ2NU>`OIR w٬Tab{`t2 Nn[ x~oO% %< f)Tܩ$À7kQ1 ,>\(L6XGf*Ss,g:^ˏɬ}rU͠ o/AN@f׻]=WXz#i'nm`),رX"=v"q7^n^/z/ώ}|9 j)V$NˢD0Hv\Zay[~kSڇ}p޼gPƔܭw#qO6 1kÅXc./M^&ˆ\Y֏\N؋? AmP[Sjk֒YP1H~|%Za=v?:LB78خeqȺL_xx X^R-%}M#7)S҂Jz^=Ѭ"N٠ǧfp; zP\7D$QYL*H)y]*XJM}'EE)4YouEbZ:v2ךv|'}ʦΒ\./kX^Dk!P#$Arc%B-@K]4S)`{ǧ"(P{d"Q'e[W͍̎~ԣa22L2fA|t, _lۢg=m7y *rw4ДdzJD8#a-h-`p"NiDC)4>JW ^ˊHvpOZM ə<z^nm%7sF;&=DŇ&CUnjaJ*9r^0R `eŭx6uyܺYN 3BH{,;)vJ&uE3 l?9wڻ jtnvv~^$z&#93r!g'_ M2|KZځ6MdR|nP{CX' Ue4HΎ4VeL%S0RÒzf?iV*#?ҘY8PL+Iq>zu!JWO >ߑNo2Bmӻy_.*e~=5s&>9PRC9zPJ +oYVWԊ٨,QG!uf | Bu7t0%їvMJc*2 K"޹8KGXb'eB0kUzjDxH+v/jх z6z-Hv /[ɒ,2ul9@d519Q>K0}{eG@6u3ilQ7ާt3#X4~ Ͳԥ[3G/s2~(S_%9[} ]@ ]ܛB]U$Df"];0i7 Uiّz8]>okTeznʹ2hMnDemp=J*`c2+_1b xlup`gmt/-Ck~L\5ѯ9%h2!ЁYAPi_:1+مr^D9j8U:5CjzYx.?>y ΡzBy=58& Y"v۬1,f 2fӵ0#GՄ(y)%Q6P04ٱ#~1 7n+N.=p&`! m= t^:*Ee*7G4H>J7R@2w1HG26?h+R[1p5ＶBVw+*l?G2ՄߐIv0@Y8m:qfl9urr<3ȺP096QuM;62;,E+#w~:e²jYb5? &2)|IJ`ذ35^d]4#='v zރd`;0IP |# +ү"pLR!j f WZQE&},}Qycfz<L:Ї- v֤pY(aT<{4#3yl=pJwʺ> J65FCP'SV@X.D 4Zx4ޞ 4rZs)꯱䎽|[_Hgz_PO*D_bcrFLo W)44)e U!8d0iPs(_(~\KBcrJ`uz*,(GPsnj{dT #)&dSJkXI— Q[+)(l(YA;bH!ё@W߻w=ϸhl$w0 RaHֳ.mQ齻g{EZiĀZ>_*l ]c>$uG@˺^C.9N^ɜܐ8pݤ!F̄4ov x\a'aYV m%nz%ѡn鐒MۈyRX5- Djuqp1!~I/p-zH"1]rpf9ܰ%Cob#r^qD)$#ΣL.ԜԒ~~3waf 3IO9W)m2 ~?|Θ{ .˳V4v̱@R-wGrkypmno-v?5jI(ǁDoS6%))6EEA}[`AԈY-[9'߲yj:ũP 'z  =dM*B<$j*yH` d!ԣ)~v#@w>FuؐBxڥK$&qUM2^l/1x+?~.+/mr5i|1'^wlkInj#dHD۶Mܹ,t8G#@0^{֓r9Ӊ.`\4{!8Ŷo#ơy$AA! kem;*b!n]-=0$b9"8&z3W\Y# ]vMEUO2DK3[zx!dHr48*5FváVR}G@.=)-@uwk1}^78W߅%#\ }3D1@iפ9c5pI"^.FpW쒜x5Q CwƬd4OR]N)|Jׇ\LXZaM̤ 5#QS9/Pm/硍_?B(CrpznOkdmү..^qػvrQw+԰DObVNm8` f3-N2Lu`ku0pNqWS,Uw`B0|FJBeypm-X`g݂ƿ6}5GPN?,۲q4NW׿^ -b/p{-##n5|,a=<;w2N 1 ?`fqIĔ^ Pe`XLG7"+o#o"1cz SԂN ˀv*F-Nb+tݶI[Т>O!C<UCҋؙ[A"\PE1mc"S{諙<,Qc&3ê/\8r:а*u6Q i(ɰG"1Ra"DŽI(m1ڎCۨgy\ S馶LOgL()+'YJv0;x; XXzmp-{9Wf-#Tm 'YN!Z"#+ ozX<u$">);*ޡTQ*rCsA-4 A]! cDZ+tM>|szrI=}?D`}Mϓ$A;I&kUQNn~qW#Q,L9s ,#Gwh/uBZAEl- {/^Sw>o~> ;xCtޫ:'dhú #P//vRU[b0(FKI-/}\cyn _bEmW2(H~2# wP5q9kuZCbM[Pp'Ha,ۻa?*hDS]! [\ھKkqֹn8Wr fl0xD.݉S[syrv?jk>?Iӟ0?, 쑃<tn;^_ Eڮ rJw$%_ߌbPrQE"m+dO Wl_DDwh7XG:&|h&a`ɈJѦjL+>PT ,,6=H9iTx}}qrϰv [_[fq|s,;&Av[8^d1f@f^hX+ +  72r y ʌ" w91_ycUe&t T9?6jD#iHWD 2TjQ%dFV4]ߚoX YP4єO^\۪:9@Y]fOh6sԄ]).`'S;jBC0X|Po /Ox1?=Б/bh\~ 99?):Ёj DHg6k۞_ qpٹs,KnV=ߙHP67`z[In5,:us}c6>rhZr ôv[R ~iӗmi`Lu%/ ,w;F[ t99مY,A-X`;KO|rl, g@eT)mY&b5$Q/my.QItUNcI1Zy:tdQJ(A.)}$iI(ilJYinVjf?v&^BcMp~Rdfq@cj3ϲ&mN))OS\:(\9IᲖ-L4 lu;t<35V VBE~d7+OQ3S˯cK $""iBxu~nixnhYX],Jfᒚc.yJ~%){zƔy+AO'vP#~̕+,j`G Bu ␴uQ]Ҩ'@@:XyܮCEBF7 i(2kU^&ϡ$"!FMsuBJo~_{:/]8dP;>?'/Oo4->dXu:u|RĖo` ʹ"8uz!.^%7e|/1 zE+\ —dzHԦ_%ZVby5F0gf%d_S) N҂. 宲A`vg]Я6pJ).6FXz&!YT+mM8+ =\?PSUsCI,6h-ʜy{7ha7ijLDxV34a!vH_W€H"Gă ;ϼW*cg*؃vX{ Vֈ˒uRSB%v 31ilJuǍNIY#GF;v*Za g{Z9u.-9 iBN~/~!'_^hQtg664Aė.h/_8qC6L[1̈$P=60Rt?NpɣJn:uł<}K쑉sw1!<xDnߌM[4AIuɨmmEDL'ř]NiNƒ7482ZLJGKs28,\f ]0^h:>$=L*M6X^lä$9T'zbn+3f> $hZDwO]D2cȬiD-oѧ kB!a=֗e^Iq`T|+܌H ӵ|®yʿL{"DXT/9?UjO}G:[՜gm#LM彥I/~MF0R3< "xMw+n6xTׯ<5:pTO)!/*<$w}6U$MCsYgaᤔKRco ف&B$_OY\od.6jt@kRv~(G@ 2 Փ܅=5亖WgT|I]<ĠvqjO[ )^HcyRX<TٽQ(djӅ:(h"ziKJ sDg8k8$U`Hkg!`!B;!7*(qVqt¡1\YX'D)Q5sÐOƢ1zM<DY12 GU0Qǰkh 9~9JES:J~il}m D20}JiQMOEjBR:A~`R iQx"aCI3~$^/M:**7}Mwl3IzD%B\޵Oa0JG|6Ut,_aó6XḰ>Bf) `RL@8<%ـJ΂TI{Fۮ{m~ $J5D.NSM:nsE⻽" Y4BE"X><ɧJ)Tc)'FnPMH{N&Ԛ-- R Wѐ*Ec "@Fl~9QsxXU8Qd dI:JCbs0y{+8C ȶqǁM,{z؛M8rPS~R\]o0ܡҵ9}Ni47#FrkVI!\k KNq@_Bb@FkY'x6qV/17 F UUmu}Eyƨм.oU ӤUs :!\[Ɓ;:)^` "%=p%cXmZi)^d/:܏}7|T[K_/oz8"EÞ:;UF Cwv+QD)2v["||}NtH$pwmjP}aL.jFFd`T.ڂ jC9y:{x1:siX8D3W:2j1ڦhjҊƮ[Dbl"7O;Qh <+ $-/r* 00)~PRRLO8P5WW#{ل:U*,˓o؜Ƿ2a10\b> a^ďy()XZ<Dou5@!Jc}0ȜLW\!b-%,rJ؜g(Ψit zi\L.r9;-es$Y(PYs+hΠ`1 Vz `ڈaLYϸ|L`{0QDצCc.?kVCc{ E =7-dsA·tqT RjBuu862׶e:7fncs!0 gށ .ɼrMiџ~љc&24(]`],ȒĞ'-9J^uًbTV2z Imlyh拦1L{Bn7bǛwE[ -: s]eJC(Jy?* ?߿ M򃁧nA]m#zGu׃`d}sS%zcAOv?k+RI=v^Xy%vy,jӡҒ}Weh>GÎ<"nqE=ߏ"y=B@js\PEe|}K~U~/0t\gw{`nH endstream endobj 2924 0 obj <>stream Adobed # $&& $ %4/ $('++9+'()02520)7;;;;7;;;;;;;;;;;;;;; $2(!(2;4222;;;;;;;;;;;;;;;;;@@@@@;@@@@@@@@@@@@@@@@@@@@@ $2(!(2;4222;;;;;;;;;;;;;;;;;@@@@@;@@@@@@@@@@@@@@@@@@@@@ $2(!(2;4222;;;;;;;;;;;;;;;;;@@@@@;@@@@@@@@@@@@@@@@@@@@@N""  w!1A"Qaq2B#3R%rCSb $&'()*456789:DEFGHIJTUVWXYZcdefghijstuvwxyz!1AQa"q2B#Rbr $%&'()*3456789:CDEFGHIJSTUVWXYZcdefghijstuvwxyz?٠Usp\\܋&\qp@ .. .. .. .. .. .. .. .. .. .. .. P٠Us @@A$-٠Us$H @h٠Us A $ ٠Us A $ ٠Us  $ @*Z٠Us$HA$-٠Us$A$-٠Us$I @h٠Us$I @h٠Us$HA$-٠Us A $ ٠Us A $ ٠UsDqrJ:GP9*TJiK17j(b/3>-# 9Swõ̾o5/ GGܓXE [T1 fJ-U݃Dk+soŪiT @@I ٠UsG`߫gRco#Nj2;cNsVoby};*Qʭm::j=]=1zl(+0NzYWw&"z  1oE38LHEYh.3 SV(EM$m< ][j͖IZ_@&n˃սL)V%QM1yq;h(-UkƼuO'V5-du;n)(]=V뚿r_6]nC0oOh}'hM7kïzǥ˜>bg=8O` HkivϢULCMJ.QRO@KN38bUEQjf&;cV $@  ٠Usc|+ǯV/$6z#JV://>)0/>GM1rD;15|8?N骍=Nvb^|.ŵlxcQ6>&q"*(S飄:|[B"^Ww~ߨdrƛRljn߱e3W|zUzJ%k,{ XLh5RU`ZQ'.Ji9PN+iF^ꖗHp`VQ{.ڶmfLͦ'tE4s73nrQ3pĊjߧrx]:ujF')I^vozt7)TK2Z/ogm դ׶UNXؙWiG>țDGewٵU5gT<|i%->DH$R٠Usy܀m= tW5t^{۱S6]؅f!=$/É\>*%R,!d'^$zJX[pNJabf!pLϔ*P85S*r&WGQs)q\M-I[]+iڶY cǼ˿zz1T{x+t֘Sf,W(^?`[B]d~|HOI5+qE|EU;e-\{3Z}D`M[8urOëKǫxeNׇN={i=GYz/%h޲t Ĵ;Kgwgj_4q'̏;kɬ<ښYd/`Np:D8<15GGӗ8`m7_ m9ǂg}+N_:3 kϱgc\zSsk+x\'oFZ󄴒wh:O):O~8x,#;N^-6Fݠ"2R$ h @@ @-٠Us+ޕzxz֒>'WTcǻqG?c/I[z-*w~8->xު2_&:x:ObKX}{(zm%٣oC@NN~7s}n銶ʣa"zeQ[Eqi6L]{_·K#`BMMi(hCQIz?cWT7z' } φ}vOu=^Kc!,6o'<**ѫ.̓ߑ`+廵6<:/N<޳OFU##^ϮҴbL+KJ~vX~(}_cԫVEɵ|9ڞG}\Skقmjzcŋ\'_7=9TUOm8}1b9x'sz<. ,⤭r0 a4λǹbt}Q3vjv_&6ɏwLNjۭiop:~ᒽa"w5ve=.K%x { <X<1ǫ>̟)}S"Vϊ:LYpvmlNS̓v͊fcyc%]lsY3lZ-:;p%)?/ϟ<+z99(;Շڌ|#49Zaq8NR*n^ -#oXϾ{ ڇ ҭhG=w;Ǖ16h/DZ}ӌ֥/.gU4i[3 dU*U^"No/8oRZ-h&C>LN6͝:qsjS40=Ӹxqxǜjtϲd4ԕZrϚ_y sQm{6ˋ8X=g $@@ h-@٠UswZZ}|݂0(֩gu+o^yN'q.MiM{<ίVڝI|oKy-qԾtuݭdJ=mر]QDywY^ړi6|9##lJ0v q7irTsuvM:)Ow9ԴEͯCc(wJ}6N G8;sK_x.3Ūq 'y=l<:*݄bbF7L:Ͻi=ٟiĪᕱ6YĪo2)xGU\^U&N__:<62YkmzliF _Yiʱ&є-F 4SWrSƫ:ÿrS֏oI.yv4Keu`t褴^HXjM31NQǽ @8n^k:E?0Q "c۔lH8꽓ޞ 5[M޿/D_~0KS0_j ˌ"U{vc$F2J3Jۭu_\eBMkv_3M1>jkb쌼@2\BRSuxSvNڤ>`tbiOVg{ߞ0ДzO ؾUkSo%;W:z}tyӊ~d GJT}9{Ll.'T:SK,j:dRd]ɽSM5MNq*U[={`τ%U쬣>ĭݮq~d88(yR3pۯ:08eqMu,Mhլ׃F/s1)3Q4n28o6|\ yߢmSòׅU\zbUr(֞Jpm5GOF6v읯￸a8ٞv8}xVN$ƩǢh/}qWs_o"b7'cIZg?0Tםk:~߅^ +tC?//}Ua^i7pqz9q8ǥ֟dh%:g"`|igY R j$wWhgG_֛uKӧMOWQk~QOD1NY-S^tz+l^{4=%?S>XKFclXӃ Tv2l[~.-5[W?z~q}I®7q)8<ߛ5jZO!WM8::m<ϵxL|Tm| ~;Yz_*SMl_ slŃI՞BT-uWOu7;>`oM-ٴ-Yz};54sF|ظbU5NcZFPFrKM-OhzSO"ZoʎЂ>~ ő+%hՊ侽ȪM^2y8G?cɈKjPV(ȣmN=ka()t˗J2(RvZ}~Vm9-M/<<kѫ.}g%OvykģYq1:Ң/o}z؈(Ke+m٧O`Č'{9Godcp'hĈ(yDg"b&f}\E3>#՘gpy9 XK׊quH8 %*rZ'Ÿ ;O]4EfաKBЭ#?.J^>VzDgLLV;i=Lm+^sy=ñ=ţTaE%gMv1 OE wLkcƒXUS/ymv=n÷S03µoױ^Ji-'z߀h ףV=j\KރX|(q;݋Mtͱi}'o]Sڏ7*QNϪt?Pvҋl<..gMZxxox8 6x1:bhϷE@O6Oԇ>͕TS:+{t {֖\}sg.֭BOⓊ٭$t"Vry_/WQBr_nw;)g%VnV׽|tm/c#kl]X^(Z>ͧ7NIEjry8.+k6)~KtvN50QN> TOs۪ٱ/ËtT[qqj/[[ھοpbS{IoQ?c8.R-4=NoJ tOU?׾͚p*ߧ<<rѰt{ģw/ms@,@ R٠UsXt'(Wvl.3T0vz/ aZD}tfUToUߟZ-譖6 t9ߦijc"#tS p֩GGҳ;~x<,?R7%,^Ҕ~.'h{ګk-WHսkjW*JR)[vv:5ʍV "~ϼ0ŭ:5 =#{Sa}#冯=C;oV߳aSV$Ti/ϩG ~M1%{WiulaK獗q7ODUsOrsQvZͨll/IqPtT 舣bmx<ٔy:Y#p%,/fZ:eK|xU6j蜝fZO-Zr&gxjY׿Ħ"Ĩ> f"NSqګ|{GD0N #?շF^q.[ףTi[ϫ>}؊g&y<1bqݙoc)u>~=`MQ(ѓ]4Or-LqV,yCgaᖗ8^'kJQ^.(ƪPxFFs3`DǵMVpDG9A`et/[8ʫ~$˭D< `;Z]wg+k޽ujq*ғͽYjuJӺki,LUx+fv\{W#8痬ɿ5S<OhElۺVGx:nOn{XEfԡ5i(Km[8 LctIkhgC>/cɇ\U#uћM8zN*U4Rq ɴ'ǎ*\/,%]7=TٚMpq&\:jëX0iS=ǖ<}Z /M> Z%g|W)=Mo[{u\B=wO~ߪ|51"9O{1)M3iˌ{(wj~s)3>~~ӞuGg]%.~KGZ{̕4ŐɉMA$-٠UskkEW-DR1 vt88L)SI_k4ϷW}/{Kѹbsm~pWk%_w OT4_ic^_j755^DJ=W4U)}Y#ս]S]n40tQ<;hM(_㱟jUm$pa>yuc{DF{dWZ}SνW/d4Nq*x52enVkiupS +-Y|%\*oyT_I=2oۡlQ=ck۩5wTqp-\ux ㄗW{zm~g3 7hgYQcS{F~N=^xS3{qq*uA^Jqf{<11^6Y,,VJV[*"f&iYjҾOk[[%ȊO0 mx_++>r㕽? o2OY4ړz{ѦShW}i zQ􈦔_m=sxh紼T0M]ūǞ}}KX&>x)^޾4;n]3>4Kp1c0۳Li9z_#g>6XQZ|oCBNv|bЎ&+[ λbK[31fx k]cW4r|xsLJϿESGVl{>.ՋN^#7ٷnӱQ\nMbbE9vCkKW+M!*WLYMeg(K(5ێP#Nˏ^YXKT٠Us-4Wλ9/wU<>.'W>LtYeSn㖫'WS6n2O -Ҵ/|:[JHu-fN&Frw.7ft~%QWO*=W#QUYoq􎧣q:qRi^گ \M,RzwO>&QZy2Vzhʜ)9Ir:̞dWߤ0ꎛxXt1e~y2sŸ8^?E*(Qul ~Tc9/ZoI}-z0YS$D9r͋͢Vf$}TL^4bQdB,%EQdQYspɮ~Gץ]O^>5^ SQT}v>-f"ƅ=O58d-S٭_ǥZݫ[ɝU. xͻכ>*ܪD=;)Ypi&{1bMr LMsq=ڵ4ם3tcu'j_w?/}鸖и|׷^| ĪRSVD]Gt,Ji>{U1F%=<&g2{wzΗg΃ǜS^މn:aE],ZkGgGҝT'90^#7rXW۟E}3|t:r^jz3[y~ Wqh?{bz*{O+R}VElHmtU;E>+GitU{Θ't Z9ⵖL18OCU!;#~" T^yDz([\Db2tN!Q~G(M%pm5{gm}&եS% rKvK$һ(âm{B+א>7U8i-j/tg5+T_(bJqq pAZq.)#p&8qG]{L;|/[ԪS'L䮌J$g[ڏ4J[OV' L߾a=qt:^Wpqe KݯaCz24'SSϮ_y8!T_Tʜzm}(t[Rk cSnQ>(6OihՒw\,T*_֖>xMI_L0NxFKU1:پ^ńV5[qh9ߏjm5ZJԠpgw>cms[t8,o\\4kW+fj꿚b&Vݶ|VdtS8:(}NωcS9i>0&7hw-^dR2ٯ:R)y?b#*OosO߻_I8ڨ3 Q8UU3 jUWBKbGůZ?(QA?i }@B#U9>RTawWǧdhZM#j388}O2p6ַh5(TtprJܜzǍM,X5Z*pwqXWCSYR䕤sºwO['RHeSfY_eki}s/]48|S5Ex|PULoS-ZM/8;iӼ3[ƾx~*N%FUHJJM)v^GF^p5;i/fχp1pz-Gu1oih*Ҩ޷yu7>[W~NrV̽qZR&s/g9P?ׄ?3CMJEI{)#' /^Kygj +p}6^}Dwwq .> T{nRimUʹSM_EJ{E[Dŋ{j#۽il_2ojrz_Q&'5vj9U>mx@ @h٠UscGQzm*5<$kj%Jzn$* ;djAWbSޟ.qZq|mzz?6uR^ʎ0_B]>^c}ғO+v-K{.>j ?k=7~Ǖ{Bm}OIU:bS>3]?uΞ<{^uPma43j⡑$F#l/%Z=vQpL4^"K}#zwotzY[q[>]gQ8~ٗ*aZ𫦬)wjc^ R)j՚l~<ͷ%ly?^`po *pLWw3߰U4e>&ۏW^$[{~QǮfN 9nwq=~gУǨflʸIӳElXFo@"dY"a1snZwWr|BPNʬe{v:^+O^5_%ĪfVS)Vi-bߓj^σkjQPKI;M?z8]p՗vGϞ*xcff'>=,%gM-h!e ћ2Rv7[׸< [VaE":f760ڸqgZf'K&E/;iXԋto8z5N_)})~F?w]1c0|Zn4__D+I*CtOkiۥ{xi:q 1nkѧ~hNxeT]؉} K_ӳ󦊽0Զ});s§ԙ#XR٠Us{~OVI/a}7 R9Aj4k*LRס1-43lhv,^_>[U65(=YhҎ^ow, ;0f+ضΐǫy<_S_K&`qn|kCԪ;pت9ݤUGMӠ6+If:67FV^GLNDvnm!jU2p};~#D^¡.?OeW#+O;pǙ7oJ{HΟ%MJSt&?N}vNwjǫ]ﬗ;Fo}Wu5KZ(x_T h-@ـʹ $I$\[ ʔ)6fsz}Avji<T-dqMO.{qbt8îbGPBY㪜2?61p'kTtHR8:S,'晟uspX2UTLW;M11:us Uj_:þ>qz{ %.)ҖRkml-s::BNVqm4ћ{ۏ8>jUD",@ EэYD%?fܣqI-UFóNӏMwiC{>//H\y#p{W]?Γ펝ڪϒ_5yOcNrʶ} ` lpj[JU%.昪0L^VhEODJw:%Z-GǃUgEŋ,؎롳:'9xpp;䧣ɿOj:yz]q;8R5%ɫopx9Wgc}aQJ1S֤mi-m4:Kx'i$zWZ?nLbQh֯4U1-<~![rtz­RM[+B1r+&ײYxX< 1tQMlR/DWƳ66wHaGmt& Y" jчtf/0~!gSbM~OJ-_&B74_gzjg4Zi}qO1i_&acZ2v'0te|O՗;7OE=9?7ؑ§-Ֆ⭿D;j*ZـUspbXYךXN55NOz_0eec9Lob]D5o%}?iY]eat4c:Ӕ=Oc;,5CpT]sЙa+ZIϏcC({E|);FlD~ ~J?4_E_ aUan0JQєVRmm 5b\:$Ҕm{gkY^>s\W7'jݷҢNi^Z< %+E\_];Y PXyR~YgC)[3o7ӳQEғX\hz7i1D[-3LQ:2Yͥm;'[~(W|#h/)>fʶ.Cg! QéMݲUFҍ̘BSe#Sڭ4Z4`)%;N+^iBI]vVi0Eon~b1tgU]冪3&Ѕ./ь"Ru-C*uY{ίǴI(t?YnQ쾽=ۿ1꽤0=|Pqѿ=_:yˠx?G/}gWRU[֯K {OSF+`uMk{<[R?~m}Nyޞz~+>}tՉ>?C獋nbjǎ6çGpmN0lWg ntn_6.5s]ST33剓-UdRـʹ./5-c澮Ƭpm=7)zs=Avj>ׄ)*>gd)tȢ+*%CvZ级/)T;,5SRV/oy=.CGL^zxi#ө L3oQ0ՏOKef^Ka_ŞktfŷRN4$J Ş#'ݵmwv6ᴸBKGXU|.15UCt~F=N$I]m3DӠg6Jk_2G%/ûOb>ZPnVEsz黎ܢBu]F.Ӷϥ{~WN&,Ze.lsSm=V*3YfgY@2SIIoq٪;6q0Z걥N.RH~ ye\-ST&hX/iˏKDN:lsH2SMLE ~Rӌݺej.1^_6M.k](6fe~䯻쯷#>Jt2,.vRQ؎ψO瓼h߳^&*+ÊLy/Uߐ?U\>jK uSvΝ]<U*ryZwooܞ7h*u#Ui6/GtwˈbUI^gLlW5_.<D\=\k_^loBkj_=):<~oe-p*=_<%s\SS>g>s{{QmQF819G>~jǫ->ߵNӏU~ۼe.$/WvGIN~W 5Og7tGYKTke#ࣇ(GB~/,{<޾Q~t=݌ 1U߫8m6ÁN.%Uc-igZQVDJ"-`9$ H 0pFf0]eƧTj/*p|DϖϽrgQ#(vt b5uHJdiKN߅[58q9Oٱ%2];WEm7ʨlztcQ7b11 ) U˺_g´Hu8NwҽV SMxJo^L .?AӞ/%8;p&Q-4WVQTMUp, c.G^ws?`xFZo$fZkfl9vJO,YpV/5=ɵSS4k8_83x⩼V‡Ç^'b#WQwkK'bR!*3}dms[?zJ5X|C-ڜ߃-w3DUwW'ߛQ*ҩi0Qrnrߵ# x,#B^: u*RpDUHʜx4q񘕋*Q۲mvfgkN~;fvHugɥKۖU+% p]ocZ3p,YlNP~~WPsUI&f֊IaFTMxN׏ ѕMj0f>xeuTgacqI%|c |Fє<ѹx>#կV5? |F4]0'8Ui4|ݛ]ZNqQ+m]Nw3𰒝3=|t۽1L#Y>~ٰO\ "Xv<ǯNķE\)שb{}I(pU^0E]LV&tE|ַb_%ݟWhf]YtՋ\:>˅MuL)ίZ;gH8 W̗̰J]ھ6vҖrzJ4c(;ޭ쉄>ٷ}>.sLN^sDsk͏V-UbNz;#H|h-@`9eNOE|+KX=w?:dƟv{KK+q_v_M{OJj2jg'J*xi9if.˝<:id!:Wr0v6g'<~'qXReƩ䨭(GI&x&13p5BfhRLLZ^DgeCO[kg>; K4-vEej7&"LmiӚ.y}F* IrufGpYfUR5_^[G7uVig 0v}>eDoWD޵7ƀ5q\*rV~zM{ q>-%k.WN9n-=u9XnbGMr{N%FO~iwFtտ]?S_7bt3p!xhP윲}$LeN}M&N7/"KFIǯ)ބZ[181]7'I@3q5{饯)EeÄasa5Y4z*1qMiggܺ58F[V_H.jZ*genZhdģ~1-QL-(RڥpYR:{N<>QQitm5gDx#ա5>xmqUNyLw\L -h̦4:XLCA\ֽ՚jhφczAUqwv_ap^⦾t޷ŋ-FqҧtEfvZZnpޫ/S_odnk>roZbkE=_:AW<Ҧ˲Qnd7? 9өe,)-V68kE٭;׵2`ک޾s&5ң:-^3W$e}G?p7gOJica4mMXm)!fe8L%|'n^ύpe:]kVUe_k*b-8F]B[[7V?w}_el<:)_N-T0y?${~2[ngdO|DF:Gs秲͇4/@ T*Z@9zS劾# =^>K{Xϻm3z4]ýVQpvz5L<NN- MwV*qSVX"c8&װяLÖ{NVc\wϭyնgc ;&8K8 gN"-d">ӵQ3U0FVaqpi-/3ҾӴcD0|/:=kЯMw ŧiő0Ug%fzl\ Zf]t78GI!Ѻ$FI4h=u6SDO,3L1xش×KJ-%휟̸=pgFxox>r85 ՝I94u-;>w1n#~k(ZJ 3? E:Ur7e^:n֥ӫQӍ&K^M<"{񬀽8uU]:SZ쥖2{._2~m#,O4eI5f\?b^1w/>L~pVFkӃ]V EQܦ;}Ht8l-L\z>x_Uk_TxVi(AwO~CrO_E[]1qM=>}X[,S2S36ixY(t8.;Y!rV#CBּ~qR I+rGCۺ6_=-\;ӬzQs(c:!yzȮp޷_'lJ[j0%~ұUꥹjLӤLK|Ǫ^CFn'":P!-t6. U{=T>ÅmҸX[? :u+GkJX )/sNqRw"ErL¯i{Jv1p:ee^+I&׽]*p&9kx[[ NƟI𘟞BϿwZbパ[|6ߴ_{Þ9VQs-SRHō*o(ܢxBҝЋLp/d:/]R诤r\1OlD?9arM/j)8/ƙw *e8| x1f|>5>o9+GOWdqg  ֤FRES{1oJ3NiOz|m]YQ#ՈvX,[.+IbҔ:>sN`8r^)%_($W츲.ŇѻEq=_#'S*9G[υvU'>ozbسq3g>4˅`xGqu:R0}bpPڲ^_Q6Y.T~ENiEF)$IY6lovO |%alt&Us#OvNDaǼ:hgīe| 9zӖ/K6궋SSG=*Z@YG0  H  =]jSYi/zv mѾ!,ItY~!~4~}}zR|VeW6tU0<='E~򫹟V4NBT7|%,JHF_j)юWz1,%g,SMqx>&Å.M몞xhؒ_ ߫yNAs2)Y񽧶\N v/ZdZ?/oߦY=^=5?.%$]qY#ܮ_3$:c6/,FG `h43w銴ĈSO%'q:]|ٱit_Qڌ~y| 5,28+T ={DOc${ELDGl]qZՍ7Īf|muO7ϳS)@M/EO*;^Zjm , >HDu~ó%ncvkݧ=znKM)ڳ!M`gqL1#UhXP-` 9s`EZiJZ, 8@-8[Vc:Ν$@ ShJ*FsD :HɅL=Jʟ%pZXsj L^E9+lHR 9-bSwL@@9$jTˢ܊xw-YEM ȸ`&;-fszldN$(X ΢"TՌ2Xʕ 9G_`\ׅRRxn^1Q$[J{YEDA]yTwdBZFQTȫ `R5SZOB@*j…ed8W*-&4m%rRlɌ mE@ 9%EU)ҹ$ &JeIA ,Z$swd,Ds5JԔ*qh17Rv>'n )zjkm Ԩ㲸 ss0>bwp+{nFcȉ<ݔ:fJv{RYKP9&(Etm2HlY8ؘYA "mi,`83: Jݤ`5V.k_v4pV;@{-NiNJ\qRr^$3:U}[.&-3Tiz,((f̑ȘL>q5S4ͥ /݌nARؔ1wZ b9f- 9 TƩ,VgxN`&&Șup}hf91q I+=`7V}q\2tuz/M]+ Pաɜqi?LYK礯b)$M3 DĀ91W34amLSyq dr+HHKأZչzȒUFSFYE! B'5M]g)bėZ&D +HӠbcKM@P]\N+}mS>#K ~, ǡEǷ&9NZ"nJ&[X- EY v8cHϸvJUgl&q^:QzP" *C#u}]}|gOѝ];C>öFɅN4>zKErNYǷ/*ePGMyXTZ*^GjXi1JΓVLBъ&UNRhձOjͩ[}4vx.Jb׊*xĉ|aYW10ئfsSLafbY9wETT54w9=+TcJrZyT"^>FEQHDUr һo|̦>-4)WGP#@l*syP1$@ezMҟD~A\ͧ|/ DbܙZvŹnȅ(rmubLXLp/b|KSZxݳkd,z)17ez=phiѬh>ASld6ֶ5|B0X<*{48Fk1hҩikc˂^kE?jRw;?CR#zyWI驉dnjcc6{:AR" ?Jގ-8:8<*,b^/ff&LzWU؜ɜ8{H&Qt+N62Ud*Z 9I!8np+PxtD0^։t5qgM\%%\xIS,>8GM(\<$%GoSǞEdJFXu3Bxz{;RhDfN3Z0ַ%Tg:Q蛖D_F:5x^&\lÕ'6q炩 &`j[Qiɻc jlwh>0.%cKZNld{8t]Pճ1MY_>.4^ J^L)'pwN{w2hi&Մ,َ,u9GY^Ϲi&"b_0T:RYt)+jYL BIlZP)( r嬋0!MCc|kMLg,rGdܝEU6.e٧o>&)cn*ju}hfh 6SCTYŇ/UiZX(3- IcFSieYDBPC֋]LPj=s2"\>oZ)3}QfbƎs=(V52\8j'z(q^fGurR)Aixf3E(մz#%5O mTY1bz54E]ՍLR#9b]ܑ`s b!f0ae麇3$0-<G"4ou\SN"\Z|ri&,uX]0M;`R3Ymv9嬜IW~]>riøiӺ,sKEm>ʧQ9YE6}Uc̰UUԺi])t ؛ZK@ 9h.cX] .Ğ3Ss-^*^1R`-L =XdɊ}4ӌn癞 X42&[}8챌Erb: YÑGIބn[ LcJя.RdKӭWO 2GF'uTZ2N4,/j3qzqF\"ޞT G"k"S_ >**Ļ˯FU]2#ڪ(M92a.Sr!H䨓b&MgIA4R.`Eқ@*Z 9$$\dE]ʋ&#( @T 9h- 9h- 9h- 9h-@ 9h-@ 9h-@ 9)*/6Wҩ}}8uդLb}t-J++JKftU¯mTLOlYp @h 9~rv^>Zh-7ojxSNQ|G.[E$Fʚ2~y9ge\?DFG~cדƸx*}5kh}/ÌFnOa#eQ.Nϒi3孭KϦ/`LYI3SSEmSTh#NaφiQw"_{f .Kܗȑ6U%;z_:uq{yL Jb=__I|o)Mn0[+g^ξ BR9N7iOw1띿xS O4w# txZnɸ|lwXn0.3e+GK/tuX(*uDi-'285KOϴ5MtŦ"[_GJm4dOݯnbi=%]}M8aSTk x1pZ٦/rzjGxӒ~*5%̓U8ԎWFaDEW]}bbmU3njZx.a;&-5i515aQ.yVsD ZK@ 9|BXJ*U>= aKdrxH5ʔR_Rgݲa7m׻ɲ *ja96J*̶utZiמ2jp"ӑr>(` Fș) Db&R1əiFe[/ 6URC$d$l ]Lq5[&<-`Gt{avڥI5XI˄p]O=SW\^cbW> b0x{{hp'Sz/1W2] ގǣ8&9 ǣ8- ǣ8- ǣ8- ǣ8- ǣ8- ǣ8- ǣ8- ǣ8- ǣ8- ǣ8- ǣ8- ǣ8- ǣ8- ǣ8- ǣ8- ǣ8- ǣ8- ǣ8- ǣ8- ǣ8- ǣ8- ǣ8- ǣ8- ǣ8- ǣ8- ǣ8- ǣ8- ǣ8- ǣ8- ǣ8- ǣ8- ǣ8- ǣ8- ǣ8- ǣ8- ǣ8- ǣ8- ǣ8- ǣ8- ǣ8- ǣ8- ǣ8- ǣ8- ǣ8- ǣ8- ǣ8- ǣ8- ǣ8- ǣ8- ǣ8- ǣ8- ǣ8- ǣ8- ǣ8- ǣ8- ǣ8- ǣ8- ǣ8- UEɽ9GOҼ_g5}GDD b#T6] wҞ|.w:zoNAv"r0Fbzz~ũfڱNs2‰99g#JFHb2 $I%"Fʰ !@6U[*0 6{ E~*'(qGI*FRI{]eĭZU)}7Y4SlϳƲ=LO<7Zjy׮xMՋ+6çժnAFQOC*)%]TU>rlzI/16uL΍rpxaM>g Tڠ9:oR"g5z^:E^;z7"vpnz7ݍh1G_#LmlĞ%SWEM/y(H4{~;F-XS21&@*Zڠ9?Ĭ% {F-ܛ~l=2XUO$-_x:vꚟV3NkT{væk#ǀXqƝ0隼:GfgYVr0DFHS%LHٖ! lNN˙`z?N%ҦX^^KZ%FIfcfEto2ElgKjUKw8Ѯ]8߭dvx^a:Il?ZF4~8gU119iLSDxJ7alq[\XTWLUJe&Cd6*xHFe[- KiNU5vehT-xv;ݳ:Q[tjI'Fg*e[9_WjĪrDCkиbbUmf7cUV_>6[]TNq>#*b8Zgtz)*^oqmTk;ܑp f @hڠ97`Ml aє3`%"ȚT}!%NEק>1VkwtyFn~օ yKnkެ6ivWDpT0風Rq#bpVZTQشDL1 6vcm8tNϽϩv𱱹Sfilhq"g+KF16yǯx"LdQ4B@KS OFKz/󍞓xn: |~ȹ7nf}!yi֗?%/:|,uLے5b*lgШ$l©PjFŻI,{<$Te/m^>.^\Lcu;Vρ"Zfto> Aքq<ʤu$z42SK0e KGܬw X󗼾ȇG5챦QDw̼XmεU3Tڠ9kq9a?{}V'Iq)*'7 =h̓j /{j{G}_M3TFF릈Ҙcp%#bLgk$ldU;އq(`1*|]9_mv/p|Fn4;NQZ)-ds\_3];%xG;_NϋM9J&"KbY]VU~" .̝Gqm>-)eQƸA0o2Er}|^tӧ/Wh6ٸ::>mq⬣۪|Ȧ!Vʹ>a(J 0L$K.ԍ5䗽Z4hͯ|ލwxDmޙׁˉ_)g>Ce%C*l@dUa % lʶZʶ*h (z>P}UZy8>oZ=GFUG4Q<^>iNn>D x:T m]l#\>0.igH{ќ/ڗcu/Z iLDKtoUSn!VV$*Z ڠ9 v!a(Χſr ]n%4s7%7g[9b]*KglX{4Džūz״XX}Y#>׋UTi| 2@ 6U[*hH*-l@Vl)H%jtY(۲;>Pܿ W_DbWU\鈼ILoUX1rIy_3y#*6/=j~ O{TAit~_ǡWYqoxS]~rɫl}USٲLM4U#%j5ulʞ;Npı KՎ/ii(ٰjūj)U3S%R{âd3e|9gXQۑvΚ+)ʚf-_4Չ{DpDewQ8F} .&V|*̩V./T՟.W'׸ҽ-aW7g&$BQ!üEH褗]ņ}:jE9tz=(_){ƵZyV+B>iԗv8:~_į~ݰD=GDNUM3޾_v}5S>[txî|5ao<uOcau_QīzYb `A1%*: D-iɉ] #0,IZ./ ;ɌTJNM@N`1 ڠ9E쯦{YtV'e{lx}f51ŏV> 3Ǖ>SGۼe[ !bH3ތq<[U*I)$-7s:Ag;J"f*+NF$MT^֏ L^1u7%^b8'NMNUGfۻQ6}X[Hޘ-3_9Gh",!Bdd=BJ%_zy;5%FO׳^k|ڛ NĊxZg>4HrEIGB Z.SkL_3N%%w;oYm}«im131xaë qڠYaohƿW<]b>aM'k4"{i^dĮ-Uv˲4/4@"v jB-%up:xz[^߽hmػ5Oe‹TWeи1}"o=}HrҴ?):1GyY ~_>'R/*IA|,?y}ѫ4{ʺhaӟKu[ #7\gb3\vڻPD]Y %А]lP @ !L @]kJW27N몾Y>M!j)ު!S*Fs3Sx4}3COӋmj>+{O> 8bO)ݏɫ0 4"wgᔺbꑂ=cmDZޗǍ17#G?V%RV{I r*Lu =!)ؖ ؐ2=]$Z{1 ʖdfTv` J윗ؕW7Jq 4LlW wb|{*RoPXLmLڠ9XrZ#\6{>7u_T=D~ֿh(auY*S6Q[*ٲaH% dAhH%7$h@P$eJ&xDL"gHLщDc窤7RψuZeRZ~5!^[E{uKdVq?lcy}Lmb۔>͞Q~kQ!nĎ6*V1Lzy{Mv[OSK鞚;/G(S}6wQE/=Nm*i|FQL7 CV'7xq$3n.,R,#zpc-~EKGgJ RT gثV )lMI[B` Ԗc/ʹ$z۸KN(j *ZD׿3G&+-ɍT,`Ԯw̮)(DRK|^ ڒĎｐdFle+)L4~*nT e^ȅ!I -);-J})nC"b-PJ.1%;0y7rpE~U;NskK2$)3@wrFwT >3pjNwJ([t;%IeK-@6FwCw w@ss;nTgB $9x5`-;.O７ 9xrk xj g};*w32,ٟyo;9xȰsgdX\ gF wTg}2ws>x }9Csȸs[;yPٛ35̄/py9 >3 R} )> foz}乵̪%'3|Ó\ʒ ＜ϼ;"Sj-d 0x b:2=O,ջ&l-7%um}uu3j4}ضků *}ּ03 =Q\n4Βml8Jӏ[0O) yISgOLz f䎮$}g%_P>k'њ٧ǁSK<½Gk}Z}GgFzzCf³W&3N8rэ]C_ɯW+Ozr&C4m8UiTOj Hd*+4UxDE4ђ"&13B$B&hUH LЅ'sp YS3KcӇM4Q5͠Hͅ5MEXhKOڗ1X9PU$77s"RJ;Q:?#QSʢ$橙eE'5fV_ONbQ;uxtsb#vӢضxů[Wz6&5xs9|,N7W~;(ӌUؼU/ UobOc*ЁeRʘMINQq @J9Iʷpe}PciRV"'3.3eHTUIĶu-x7=ڗȮ$U#-܀$K1Py*l[;%ĀVLiIȩv'0hFG&J؈q2)e *]6J&,-#ʄ)TL@&Upb["N! zKR.f ze-%Z2{nK (V12\,w--4R B-z̀qhvWHܛeF-2 I( ]22܀b.JD!ꢉ$B YwYkFJD -\D't;ʥr Bv!L L %`!+DdUfw!;HZ7p%6h\ @%b$' Ȃy J\$aq{Հv'p ؝ʋjŖ;+MBw \(ؗ*4KlJ -d(f`CY6VOvw0mƦ-{lD Raqme~éիԒG<%:S%Ouo&,TJgUG'>5TƋF5q>S}&UB)J?Md׹V~g},&10'ۿ|QU ƉLxN^ś乆yIeñQ^H.!KggԸ,(*e>~&L+^ggJ[2َҥ\OqڗQzJ}/"϶&|>s=n 1?5s GRmxl,מWLhYuY¦x&1zς{ML7m-LOF4Sb1L3" ;)nMm Zphh} @ԣ̊F! @ xi[ ]NWw FŻNu-(WZ wШ-mB5BeϪ)qp-7m;tW*i] -)2KN$6`D&Ԉ$@^V*UbCFP\-4,JC;{'5%vʵ`%[I[؝[n3[bȄ@$Y*LXj E8ħpiIXPT%r@]Z ֶBW&!+P7rɕ&(S,b#)X$aJ*^:jĭ[(0%HS %Nů̀mlCV UR/U}$Uz}$` &phnFdInKr 7M]Rer@DP- W`^Jw&c J,*QXL1rgOLL `x/uRy|y3bUV(f1>iޝv/Ϣ6;M>a. /jߖTb``QyJ4cMe2'2Zhc 33(h)5@ #(^{"NOSr 514cj܈Z#e53j{dD,К܌@phq+i<VWv(D} t()z&+3F6ZR%N b̧m )j"LdRe ꊸ^Z.14Ȳ۔%a\)F*+$Bb4cRʮF@*f)Mȅ'bSq/J<ɅLL@T"Pq*JKV z*}ضe-ʵbEIRq-u/+M"l[5)8TKcW"+3&op}J QRr\D*D2SMȣV/e-& yۊ9p &]bc-F ʮQ.E  (VM<$.W,ԭ p,bXJ@PWKRK+lL"0%s&Z#w 2NP#VyL)wЫ= +HQr9\j]|&%or3$$rϴBxbgueܫw-B G]cr"̍ I)nTt* IYz$C$]G+lA ^Rɓ97*&O 7PIp-fؠQw-7eb dOr%K% e˲V;sw! DȖH*emJdԂ Z24phKD1-0dLU|*E1݈+16H;2XbD&U Rh O2(Is+9]%F!2`ddJ=]!Ͳl Z(SMMOFO׉Ne-NVQA(1RTee,⥪*]vO0S)(1'@`Uc$)ٙU uL!RVW0nDj3U;!V1xRĪjdh*n e-*Ae>ORP)ؼjٔ!Úԩ*N  J宥W9er- tb/L&'0QvZZ"RLgm9cv2]T+8TT#@a8@/Om5b`˹)=@w2آM &1@%(\Xs$hD&rfE-ĩ'&бpE.f̞eK\UNJNĠ2s)nY*ӘMuŔ d\g'*n$4dSԬӾ˲B@lU8A劗ΌFK_uX,Nm 9ޥ(L!uƷYStyN}U6JؘSU7@K2DZ2eȴh@ oP@nڰ[z^~C"u KQ9GbtNtc`rL¤lg7bTRWܤ`qqbvl Y-J7phPކVu`l+)&[jApc+ ,]bP唔t܊9HH$ƝS&/54mܘŲ%"M@lD9_B"%ȉ(qC%+2]$ytE \}D_&/ X5b޺@RͩC,# K"1Y܂@mY JW -t*L]"*+2"WD'v-=ʖzȔO ٓ5f82NųAye#"{0&sԵ812 v_(Z ̩xIE@nUtv( T*VYiʀhiqRG̨QEj[wK*왻pLUvV""A୯q(&4̧ޢ"S uewbJ.2f/(Yy-(47-|B(ї'mTg `!A=yBіQ(@SSѕ\H/x N%ARMِ`X0a%((݌Eo$@;^5SpiSR*Ȭfe̶d')are;/*Ibqq$p-`nVgbҝWF h-4b2SA0\H2SmȻ`7(eNcjyiUE=.$F0Hbkr"܎)f̽Yr&Hy(^2e\Wd*^5J3RTfHkr,X]y7{b&& EII@}'VQq^1MV ddS͹֡ S(pMMi+kʛ/'c/uCx׊2g٫ Ocfª'JUUhlV9vCEQ,#&%L^%_s9j^ZԑǕ!0N0_#ouM\O&Oq+*DMkQEBS pfL#bbzfS-9X|9qC= j-C饡 V,xtxӚE3 * +TDMY tZ:-8GVɔs=$B@ʌF]TL$ *[hJ@J*Z/9-\ʷr/5$PJ2a  .( Z߸w,P- .zG̪ #%GecK-+MG[KZEL bm^Ģʮrn>ҒfZ@-OVOXX;2fP )8@ -(8bЦZ9[&Uk)oP5]1r*Z^#%nE";LJ6ԅ,QV+O`J[ihPj8TXe.⑃nƣF[D0zNe-ɕ.J3YiRq2I إf>dA])fe؜Sx+jZN+QͲܔpiePGvTGr*Z22Sh,&^ҹ0H2|̌ e\zRߑRwrx1\L*n%Sh')b-e37-0RziLݴ!MHD+bmu=+(BYPq^&)w]"fCquaċKc_YGl>v|Sidvse0 g:w8j9g'% Np1Ԉb@q,^'ra ,L,n mfbC졞_Nj8;dpGPO5^uQm|dzBڦ6ᩪMکɧNjW.&̪*ڦbխZU3-@`19\Se w%R+%;Ywl|P!Ȟ{hNh4Rqc,H&C;Jh՝6JJK1:16!;0@ʡII%+nG32JiMd254h!}H%nh%r+(ةh).7@I i1fZ"яHcr_~KFDIN̴uM%ՙ4֡~OO%Hdd#u1wRv0%,4Nd^P="eG0HP(4P7fCV`JDOtP )-\/MpNGu-x%rJ-܂Q zQC:Y"%0Yr15M-Mق-MِՈNKVd* ^P( VJ(^:Š@>E\'l8X*1Y̡i=KK,R+*nQ-E C%đ[riQ+ 'O3-OaC"D1?Q#JV>en^ʡ,-*M eW" 2IG3)(eإ";7r&%;2ʗ2Z[}"Vǹޤ(c@MMʖA A&&w(Z3h $G`]]a̽Y[B%0SR1J$n&XLhe =KJ{\IFpL]NʼYC$Tc-)5"bgKdl#s_n!S|ljاLM,N*k?vtE 1R+T*ZcZVEԀ_V^*g_9\CÄÆ! S0H6`- ̴(|CÌ=Dd^2nl.TS~C I]䷱MM-S/KfY|W`LI&O3Ȃv`MnbY]^Wp\ՙP- ebqT8Ri|ne%V `ɜ2'DDeɀ+W%9B$Qe ꊨ[VM& 2"YIJy՘ r2-Jӆ]YJBt qfe]h"@ K.{rnx͹  S(Ղ+=:1%-1vdYj̚N̚˙S#ٍH>GHvw25iZ/PЂ zc1Lu`ZT&{/wKq oZhʣ@]4^YI/` Y}PM4}"Tj[ LeF2]TwZȌ-܂r @Jv&Q^%@EfTI-'tuEc"M 'Q1O`@Ai2 oD`y DrefBe zxC-f#-5_ջ07*܄j" QA( Q8*Lud/Q;-qO@$إLOV{\(2f:MlENOP ˪} X':\;hd>LL붭̣V%/Kp@V@Jonxewefwknz \ ͪ(ՋN`@2M " "uFIL}lyYR1bѪё5P )ؼ_Ym .FXeIQ`hnwI}3fg۱h{(ɃWc.>%iBQ 6)L2U7|JBCKn*2"b,Lg3)eheÇL1ahY&ZR16Y2/*~Ћ\ٴp4#J` R#^{ X.QySbSYQ4}w)EK5oW3ʷ0'zYV)rĨqghz,♫F8ÞwN]s81VhGV04( :oBye T@H"YY3VKTBjZ17m O>s*۱*. Vm%b2ӝdΞfc̳R+ҳԧX̰aV#i+!+JOK˧TfO!sOGv%-(eQ%7%7&>vYZSȌoRe,̀H^Z@%&5't%4)SM;=4d7&b2QJ`3ޥr_fDeB&@4֢2e{1vAiBڭ&1r-YM*^w f{җ?xMRhY}Ev*--"@H%ْ̬=Bg@%vP ̌HTU" 0=*mؖ% {:W^@&c/ SE$j{zfMEf|좀 ZrcX KdPliD*3uj(>B阐jnTֈDhMМe19i%0ّ4*^/2% ZLw&{Or%MK}"QʐVR )؜ZVe h3B%4M_1yv+KJFIEL؈K+!1 sˢУw2ՍF"aLyD&v2M+QjJ ĘʻW2F: |̔lBl5yMD- e\W-7˸"&zx8g^![8|w)>vK3=d(r"GWwQg/{0TiEhfXh}Vpb7c7B,*^"Hp4澡uLpB'xYkG3vULM"$:'~ƱQV~-ŎxJC8sZrPջRmyiiajVwoͶGZFU[Vx|/5GU\'0msic]RN=E+FLwTUO=FyapYw9pnE,]fX0#cW)Z؅bnb.^_1NcRŮp2Bh}4aj\) H)јáa,4JW( ѧ*Qn/hЮ.-QD:Ct+ʼ18vc_Wu(51L<<K޾8g-^ΐ|]XępqJYc{w/`M[|:ťX:6]Q\SEƙ4aa_:yQ|cj TTg:QU3F- J<3[w;4>\)Ûp}x`&&-E`_"[-b"r*+2>|,^^H2s5Uul$S$ב ށJuneqe>yI_TP4$nMeH^"83%nĶйm]~l.ӻYD \ f"J@2Vd]Hs 0IT}fʙϣ 9"J"Ij* i2i;1.Lv`egs{Bfb1tXC-QhMeBS17vA|mp+MjU#s܌~D m\ 7M]ȞC@VyC$B;2 U6u84DUF` "n셸.UXe!3㙗+hLTb43 )ؔDr {(&4OTuѦmY!6&PϪatZ@ IsI\ JefUͲs2dʢLZ`/'XLm}LjxHZlFLnY4H+s+ @δgj@nC#%ZRVWW"[y Hr2̠_&4f3"y#~D{ne,Դzհ|+D/ϸw->΅b;lDeZkK"Hؤa +bs ôDZ)ڔ \2'Pcɧ(d2V1MZ,Nm2ܴ::W+l&ȡ/s Q $YX RP2l@rja9s|]MDU7qpo4pwdlhX/bM򓷓|Ej}R˃mﾝi6¦[L8uSQr5"wx54Z2ٰ*Ϳb*5۾9Ǚɡŭ=[ lVkODBהm uyOt[=PcS咝QȎq86'my?2pՎ&2tT晄6aD& &]&SlU=UŢwrG|@> Ʉu,c7S+FLlaTl2VxvqG&U1J6e !,a>pYd[e"edт7ՇF KFd\1׉LJpYpw߅ =}G:Gϛ/U8e쵓FH`iqVQV%mnYkݶ w'a8T)1}hb5լe.姟#Q;⺸F=UAl;Rf"Iךi*KeW2Fl.aix&4`uA(C#Tf!\;Wu:u,w2h'+j(ײcp)f[mݸ}uXq/#'cϋ*dy[dʄh KV&&6Ss$GYm$4rmIu-(H6Y% vdoF;ъz! 6-Q1-25 xQ&" DZ=p-5i;2N.}PHYkrY̊?sdA1'm@ @_kňw/=B9y@C@fj&-R":%iU+DSWd3t&);, QBybɨ5vK`,P祑WdI݀rl J.$3dIPKeSثV dRٕ fȤ#ȚqʮG0a&RA0+%5mX yU8{udY Xn@-Mk~dc,$lBWAye-};~‹# Bڔ3BYՙQ&@61Gs-]0ܜ̀'6c&[e2cr+f@EM>E\^*z<B2q,2f eLaVR, 6e+5]#wdL93ytF2wѕ]\; <%r[Y]ulultRKe-`+̵ ur&1 ÓhAUx_p%99d˩YJtdQ!H9X+MHzlXr|xޚpq[ve`!*rZIYC&'W\T>ݓie&&vhU)ooJ)vT]}[E:qxvKt;O )叙jƬ7Ѳp*J6kd;v8uoF#J~\UU8M365miF<4^;4m9MNtnblƦbձXvޢo-R:aXaf^6izVYCaYtMvm;6v\3`5,$[w6)ꯈ*2Zpi.)_ cڗ~Ӎ3U7* V\ݾbf\\ 6'p)橫})arC#Z*Ơ3OdYEy)^QQ՜(qaeV{Ӳѡemdq X̩8_v3})&5MSKTr|:;&o}#r+ J䈆Ħ"0Z6ZÈZgmveRN1q@Hޤ5b ϴ DWdM݀0WdJY•:l SUj{ܕi0-8hU',̈ZrTdm T\d};x2NG223> lMNq^, 2JY]TPK1@W- [G̉G++wVD^Wrai^2HG+"e,̂[[TeiTE:L"ĦYT&0L`%[y2lW HɌnz/fIS \HFn$gmڎuy ZR̕]B hc@ыvյԊ|]GBh( 2ǼPJWV+w"S)Wq>^DOvZPr'031ul#0;cq3f&֥vDJ-:-vgM2FKvKF$/r̈  \qg)קv_xxZFԩ^>W߹}BG`ǿs0;2Ux|~01/,;J:"biIEJqmjʼnEc{*5#Z*QwMԫ/Z ]\*mW= \T4^%6z<ㄡ7ZmW}Y+1qSO_ނ<7GNن(cFJ6L931-MūЍq>*J2^G9SCmM\uh/C`T3ڏw|.z5_5/f!S%(&͚I]=uNptoRYjnz'g>KS6)|:!éa*uTIneooz8w|] 4q+2mE_=w4U=Gڟ݊c<49ʵUraE1ӣVGĜ8ԣ[N.O\tQ(m6qޛ5UW]sy\=j}qӇbʘkVĻ8;Vǧ`F7/s`bB)Ù}cQkk ªp\lZʹK%͑$Bߩy@WZħev++}n S܉AĩPKDfYTZlMLRBrɧW>·yC#J%Db+)fw >$1~V VR-9!S%Sd X,%Ƶ/7uVWbfɥ-tJ̎h-h({GexEǼe]ԥȭmӊ\U܎) lݗqrJzFfNw:2>fge7kWZzY"QyݙH=N.NtV*ԗ 1s-%es@ fW&pP0qP{'SEP'%H" #i$ (fKǸ ;-e\luL"g^{2u`z$33c's UZю+`2e3@rM>aX]WaxU^*([ѣI/j<ԗ2pՍswKRҜ\߹}_~'?Jij#W꼰W~f_nFq󕢛xF8уt^Sx~#*RNv\z8M5'reqjU\ 1v1|&X9.gQ[\tKusis$DCŚk9׉V%[7a[s_LS2K5Gda.UW6K+aڟČʯjN5Z5B֜RK1ӫЮ?'qF9#&r}8xSV`}_u:CVj1p7]ۖM*xWVZ"Xbbf!8hчpjUR$qU5sz1asdYB1Y*&"gsgA5m}#:JXjQru;%[f5WT9}Xpcw4/FATc!u, Β*nZ@~հHOrXbؙ3S]Y͊oDBb-'9XFOU XBc,ORHsjU6*jB hO)~!r}Jċ ZOKULEʜndfESq/leGXqr 9Y9qDuȜ@\[#c3 uL6Wdfdi?:))&$cem y&`DYrR؇Z+Ep|AJ,Zȸ+B  ҅ֆ'cQʚR^k'MO(o+)fk)0(MZ0Rfx%XYM\2ԖT V#T -KM;(@ezr\v A.x6'#lxK0@'.Kb%p rjnNb}@Z>E @{F^84 ַ!cP FV*]۸Sܬ[OC2vp`LdAcMկ`X=v)=ٖ [CLKdRG_b2.@s1xE0m3nM4EH-ԄM2n@w=YEF.[9v/i\ i̤2YEIL1iE\ٔ/Of2N`SrI%'+{S^ygq FJOՎ}o259e(w3[&-|XjlѹN[kCLzD}z:LVJZr{," /%fbjjfch=K E-xM5C 0BMXnC$YT:+aZLޛ;l8]6ӂc9_ȾGKN7 YbWT,5׽7P~N/0եNeQ'OwgI9mD<ɛi&aDoLC3pT$r\/ _3u|]SmUYV@.ȫ2Υ"܋&"іc#e%%12Jj$*vX.(#&3*d1ܚlֲ"ZP -\ꢉؾ3˵1IY 4B?"N 1\rӋ@)\v|Iqn%z]]Pi2ȭd34VDceȉ#gr%vWفRYJ^/P4M |k,|(c%;Z \T/Nd&bYӾJ&,9&eȚb;ebH-77⤳1mHL` I'1CfHI^D"}bqSA] k^&6^ ڄ(Ձu5-Ȕ-c.LJY4EQ57KNRm@X62IȀ{* >~A e])scьEe(+"`Jo{2ˇ^QxӅ_ZN QY%w;'nI#(uNǾ pߜdSy5E8q 15v>}0i䝗bX6jrxu)#^ܴ҄|aҊ8{.r_#H|.];NUsa}5MN#XnY55vU6%,"_a[@d§+d.D(6+*ȌR&Ud=&nqÃ4MNҺ1/ l"qQܭM ȻV^xpKB9yPOXb{=~ MWcxj@dɨ^83-EtGƀ uNZQRM2і$9_iKP"@ĞfO1J7w dȌ-V\B zJ졖$@WVc.;HHf* DC%[1$1D_ ڣ xT,T[v&35sVLX3IEiGZ Zw jzr qFP|[ p;VfZSӑe+V}'M+[QS_pO1EK1"ܴ6~A7Fv̚F2^a X^4`&&( ]4{Jt0Xy]Z ^%fc #(ZD*|\d@Sr+6- nEܕ=bdejI)9ċ@~A8:FwJVx< r e ^% (Ɍc"`!+e\H54erD 4h6( @|)vL LёdQ")Yy17<.~ȶweGO=G'%lt*GVtt: e츭LѱX,{Y щzicp͍5ˍElKஹo3*>%/F:_G:5#(oG}kܮ&tUM3iy~L)􂄗x!kڤl5~߭#JDퟺl:%&Mp5g[>-R{qie]ܛ紖g#~F8G&="ys`^YťɭWF .Rc2kLoGLr۾L7 }7k/{&U#yԴ$T.Mx89LE2ɹxkG[l*V"Ybo=%>8M<#g&6{ݿh&ۇDw9) ?Ÿ{!ewe5yF!d"X:+5*4-?߆TTK%=6r)!LSbLIĖ0aTY晃(X+莱Φ2y /E(>1i[y{9{OlޭhS]cFSU[8kR__ḷBjVo]1Q!JRgٱFljbQԣU񲗡u!N)T->cTdESΗ%0/^7mkI^riV ;"YiĴrZ*ѬOYIEo >.,#?%_zzjj솻j5oGfO_^{~YUU'6LfڎJ\@d iڕ;Z1LrvfH< eRzZ53h ]͡0+5=k2)gD'PNQ';@;AHͦEvYNVȌ6y}SiX!6ٍډEM v&)ܽI8x@g2iQ} PiXOġuُ7WJQ.DF@3CLS ]MH@2eWثɖ"Wv&%U|)d1]7vRɌ2jH5fFD`29uvDJb@}FJDJIn!3aRq-u=儂.)7m n]ӐrXIhBWR쫄jMN]؂쫃Prhe\ N:Yr+=T/) c-O'dmcec,&C?&RZRO2i;X" epSK/ q  ^&*2!l'̬}& 1E饺0s55h$j3ܧVn;/FVQ F@ 2*j:uL)ЫȦ5 Fڢ|y@ /M]/UVfwsW9kn%4}R˶}|xn`7mTWw Ikpk UvF]AZ0rWm[-j:n腀^vdU`Dgb0fUH0%;Kb\&uNYa/xl8QO<V5gGyZ5U'kKi9!*JM,pUYp'4V;Fa}`H,<#a`MS)Y*Kvv!ě:16MJ KĄe=M ܭ]ZĪdg pݍgdqé7ʳ+K+.g?p ֝_~uX|-\s;ǣ>{g>4DVD>ܴ*=̊Jf9vU'`TdJVr2FWZ;j&YV1l6h8)#M'qU6*fdnŦwծE".XQgIrIib/OaWS(]zu0@(^{/ +N-!&Swr#+-d)9Eҹy3:?+W|u`DSҚd:'g9QpUL@1 7@13tȹ78mKeleȫթm9Ϊ8ck,w0MN~F*Al=`IPW{>?JbqEĎ.yꯍ3¦k>oj= !c(eFx8bU5Jf,dZq%2Xcaæȷ/&@u{3[NY]w6x)\.kw^D݊Qlc,abѺ<S^G'ԋNb(+{NmL\k5g}VdD>D-Tfh+> yֻ>GY}iBч3%;Sl?Uy#bj֭;4zԢJ!3DwO'Ӵbbem1|ĮfISDRTfF2|@+)fdJw(^z/S%+*+Vzc/OK/" B*L^Wp@-S3G)r PM ezvD82RzXՙ4528^b^)ֲ@z#'JQ* mR(@]F4ȍG&cze حUX3-I8 `AzUɰ%%&/X2j+2'I;p\dQ݈(ԷE.JȬ] Z߼+}2+)'ܘG3*^]nJWeR3.:|ш iӾ\Jb;]vU@ShBm`2*ĩŘ@n[M/w811D?U ::P/J pd%p^+&ݴ(2AeF&̕em q !KRuk-*hM- eB*:ЩwbZ߸TQNvДqFy1}Rx[LD"[ [eSerlQ+82ihIH-ҟf- EشsW NuEV4/&*DB`Ĵ1I4 J/p \9)['2/pLb#3wZۈ%j5eLF8b Rv&SXBSFRZjFE:%%玒UX _'Ӆ=Z Z2&.6vsbeq~Y_|t:|_ vz3i Fǎ"Z0VT{,d+{iL^xOC2ta0l|la֣ 'j0"6nIb%?U 2jlV0x"eal.}.!/_?BJU]mjripMoo?ȼ8y>@8*ѧ/^~ȯp: L;n>p]=.QJQ%GRb,q=9-(K-sz,veԮcb ^ZwIk+otJ/}0Ƀˁ|)O/©)U3C*VǞ,{&oϫ16L]X՜:tiGh'ݧڧW/cpn)v_-JYU2^(dĎ o}X3Dlݽ[>&(K6Y2TZUeƋTĽ;>%EڢN w%tPg@z/QZ@PJ+Rwe>EgqOL=n *5+c#Bn ui+ ,fpv&Ny,)Zt"SJXL F#<{uRBd.\)MȴI\TP%dKv)|XƠٖ1؉L1~((xrP(3܅6 S߹2fn:6|ͣ@,(Q= -1\pSՋByL:0؉,h1{*n @o17m @xTecBg@ (ǿ&i7%/UGț'^SzۼOTʻ2_erؘɛ6ۄK*~e[@73dEiڲ@n5 NbM2V"0Bk~a"Kw "Cŀ=Qs#J#D'ɉNQ1 |$Ha7&W4tڕZQm"gw@F96YE!,T"h諦2$ք@شmQTІB";j[b*IE% \@%OWJ+/Mn] @͑)DC A/]XJiu"6DUEYd\[9D!tW `0Uwa0Ijiup޻DZsJjnij1mc^^Bd\Z=?M R_MR T+Ě{ZlW9=af~Q2SV S&dtki}ԹȡN*n-.:qƥ]3d1'c$jncurTqԉC9`^R8؉eD!sz y\zou[KK21SYjI#%uOUc@qԖC FOS:~~<F觼F觼m{G:nۢ҃-[&l *w@ &NZ 3+$Ȼd~j})@E.ctzzFD&@DU':{P*M_2U H:^ ؕB-CRcnd\9dU@Yr#,&ԽȊ̈L 4[ Ib[H ~(Z+Ġ_:["jIc/|.Swv+fZwV`^1nS:" ,dc% ݖWbn E fMbI%vPI E.XXTЫf^J {TX IKC(Оm'P-:v ~ـ(dYɣ7SnɆm#ՓSrs(QhK+V##2[ i4ʭ1r -:DB\2rQpK+&0]юRr s*:@f%GDD \ѝOVWi:lZHR0d\T5bc7$] Q-=f pZS0ة\E{lR.,hDe[*;6'2K>Hf/BX"@R&ID^B }\+e1F,̂ Ib% e=JbbE#-LБKd$xH>aŘ& EQȌ  ڲ|}q|J8Nl$fmb.ݽݞOqJfPg[8/Mג9ؚ\FK<f7]us8u;G_Y,3ZKݧ w 6ӅNT|"\ث#$TPT|uMT@J=m)f,چVEd5- &Z+6ȄI"WX\QP+*[W}.I}..1ZjiF7]+'vZU )[6a ٗ^25phPweA22Ǽ[dP rlla2f9+0gJ>ҁ4(dQyLmXЙ(Ov ,D [=e rE*{?x,,P7 I\yh+`*bfw,*_FL㣱̧+04J&7-N 2*Êx*WpBW2ƗxDE\(QȍS2JG{ZqʙcRv n(Wgr\ʣ*yl&yV|0-X \⬈ db- E]شg"!iOmdҧ5c/ *Ո-H_Tb2ғ"- d\HK"&VJzMZˑ˱ z# ؽMEQ"WOG~O[7k/MBHGY!2z:NW+t-濑Z~ D& RX@z)lg- bU2)4ҒX^s+M6NU=9BYtBʧ(&)TySW~o>Sյ]+ /Kԛ7vSTb.4Յ2;[PG[ã;$ITS&7C^\dqw&!" ʡ X;xrbmռ0l)*U9^1K]|VI8MHWvv*.rqh׸ZtTxT*8:B8p);KJvL qG~eUoNڦ.4۲: MN6NbWU}#uBblLnǰV;{saӿҾ  ޣkV&;q}U-:؉)M 2Rj{VV/zpUЍ(&۩/a0ڛu4?e(V[Ŝ#jhW=]Gjma##$ZZޅ$I6 " ĵ5( ^/"R7M]"wV @ ܎Kq0jrm2a;@܉nL7"[u%=[RmX -Sf6@pŧs% gVdF9Y pٓ5ϼv(s-̴(`N&IVRH ;>$^^-S1\,mr;>#Ju()T7q,1nω3i,%?<^%60Vˣ&R Xڢ*Wܬ%'P4#jؙMȔ"x~,${OyisS*{K̎-GMqOL]X2z\+"`KŦv:_$:=(xg&_^\ZFHš\Y̡0c{l|1Isj'z%jc#hJ }短rJ7R1Յ4Uv_,JV&!2s*+zr+OG."2#y"VfVREpаV& 4j6D"*[{5jJ']JY-C-8{%Nsr/E[\O4A1D:o <[exWMo}tkJ]ekے3UF T\i٧v9J֯eܾS2r'kjLIŪj\_U^SUwQ1r2622Q,` +kUwb ¿x Ja\vr*fAʮ4N ISF5'99&\uc:{EhCg63H$ 㩍O,|/SK/ؙ%'JޢYE@{Q"U&(+x@I1H$,ю" ʗ*wd {?x,x!dY lZ]JkRknV2a3xɴeh;?2$ ܡz[5Pbg@ ,02^t-J XU=Gf^P[&Sqv@cxOPXB5׼V.=Qr2Bw&SQ"d"3jr1,^ճ,c&,6M7ZlP@'^E W/%ɢ)phI bR箥 HX$ȡPn14 n#lUr<@OKxW@L#>"Bmr`H&2]1&;I^J7ՀGgUEȳj"ec OVQ"I v3Ӓ8LHإ(^{/"N`nP]ȖCrҒ<CrfCw ulʑK}Cb# \c1( ^(]"s"YU2bY bU甠-H_TV3'5'DBrZx,\OޓOtx*/:19>Ύَp>K}{7uL`gtv*M#hV|&-8gǪw{sG.t};)Sbæfn,F%7χV2VAV*<XԺ:$cVm*^Vzq;9df_OtzGCR}IKhLٺٱ %WϳWi}DTV2>y봠3u#F&A67GpI|}GF`,q*oiL y 9/4-G4So%Nfu_MJ&ap J1 ݕ`7M ss1eo ҩؕ%$b?Ep5v) ̭&8ԓVbt%],Tĵ , kNh׸ ^+YIw-ʹĥ([Q*dJc %'"^/rrDܰP*w(4.L(LtaŢ/Srr 5BG͂RT->`C<{Q1^DJ`zqiI}-H$eP\Ǖa:&]ddeG3-'$Pq^eAj{ܻ71HjP5Ӽ$h=lT( TDex`~ =[M Lc4`YBB񦣹2Sr %U-U@EhySR*hQ 򃵌n z+U ̀C:X af}CrLD0l )M2nS{w2JKLĀ!mX\"^(ft#"Ā+SYS$HeLΚcB0?W$c>҆{Gahr 2v|q`fDazky~Zcs'Z̴+(6_#s c3 eI*YhTLfdXʂWs#&)^( YM$je| amLabr հX57(dS PTE@KV ⲫkŔ% ڃPڲb'} a3<U2F{@"@I=R12SDhx^T^D긯cUgsãv7Ozj!L{ٸeG[iD8؆ ,ç#OӨ$~Q q*i՗Vu}n`3ɛW߉>U|8T)÷7T܊b9\ Kي@-?Dؿf Dw2vF8+^Êc@o2}%QXX>tEɀO8_TPp^{n_,œ32ffm)'C f6 AUhKEpUXFZ߸Y7e5"(ws%)6A(S+؞/rK@3etE1''e&Y'e։һ& r@\Z&*_tIi2LPVD&uNwrg4"ބ89;fv_tD`Vn=[2I䍈]hZɼ_"}UtJ,vLfޛPH*;"%;]eV%jDe+!mX у7PPX ޅG+-MeJ'R".D-3QlLP Xȵ*'!h*M3EZ'WH%IʫE. EeQؤ%'-{sk( GY"ZnF2$y xΞs_Lջ2ݞ9Rpb+·'TZlͳnncjҕt\JYJ' cʦcbpnOQZVٯkl.x59p_!zNy>)bMrͅqj˔dRܪ-(sE@DT;5`]QݓΣ4{/ "0a)NDJY,R2*"Uc  [HxQ`1{]U['"{3JQq&3q2*e $f_psE1NY܈J n噓'Y^^(]l }ۼNW1 Gsz[#Pvzh}zE]bҀaiUhYلI 2qHh+YtWFhm؜̀/q2,RzX5fe2`ިc a߁BNOtJNO_"Wv,KBԣepyU$Y=t(Jv6-oP1vw j̩uڍE`je\*p7"\Ɨyw%t1J ؋/DutU;.IM 7cnm[@Hn%@oOR;3ͣ Fc2җ"]deqd(g0a @pdQܶkG@U;ọF.'#%9_CeT7bS2Iu ZrZ0l"$ r24u NUnZ"*"Qph*N Ah1ei㥐Mbc*$)ujȥ2ܵ0~@..TBerr [*JaAwe 5{Gb}b ȘJҥ7J(d9sKĬ hęve,Tts)rDJnDF.@"zȵ#JH)f#TN~ 2f׉&oәBt-B=p)2AkO5X$\_G>k鯼=>=L3lGS]N芺m:LM%fbsD+ʔIunn:h*9楜L#:x*I FR˛6ZƜTcI%"5|)TnGSRM[L݌Ć 5HiNo`e-VPE`"rPRxƓfK(G.XeQMVeQε E7Bs(UC)RћgNc'"[XB밯͌lNva @K,,P2)eG'"P&z\^ _"J3j~LH ۹4&*4 K(KHICq&-Yel|ؤ4 H t4՟T2)`"H/2g@(ѝ.qRU=Hՙظ+MidaM,d+2d+j9li>e5dcG"[ \`KM@ю_3 ؾ<Jm@}D*dcWȅQΧ/F^ /7PI&Wj;"V꿍yK*=a&ig2h|І n muf!CBsl'$̣\͐E'rzA y(dK4}0KD*M;(p[i\}dgMn VbRWdF*0f۔2V!4PYXZw*^ʦ jumMw(V!;Y_voTJ9Dz,gbrt@UfPR9Nۓ` [سJ%e7 ]'I(ÑDeMTD&S:?+(J.XI2h d+4f4cG"/*%FޥW&%(Us@-%YMȕ[( Zb%@ \eMMZ6V2]vhnʀ.hP2fj&;-x2Ǽ&@ v#$A|Ȓ@P]S|Bуdvԫ1om$d'PѦdi^nXeMGVC#=uVApJNDVӼ% ql;QiMșvmhoLVu ʹ}QШ,zj*.EV23F\pMˑbskre  DO[|ddiVgf>2fܵ+D8DbJ wW0nFivb`"P% |DVU~m@lYBYK21p-.xvbޅ+mE%-1ɶ h),DO6@ R7* jjxh2i%uDMGMQ HM]lEgdd/~K 4V;Yjr(zXl;2Z% e $Dtb9++rٲ h7rϴBZ̆A,a"ixBыdnNW˾zmw [l;2 3Ve|Mlʧf jEfT dP)ec gQhJF.FKF"Z4ϝ;NP*%&;jU ]CmLt`-MىĀ"Q3TdazLe+0@{1!ͱ(e@ xDbeV1JnDEa16ZRkM ,a&#"eWN3(]KblTLЖV%0@rȔCw (Z+, @ԤRhM)vJr̬a/K+*gΌDdVב+-n; *InicIKIM@&hBgcNӎVTazD^=b;zYTee 9|I;C['XUdݕu*IK&l z(Jk;jC@r;)i`jĨ&uHl,bG")6jM;)g ڢM@USbS*ЋdR+:wm{14SV&蘰]/SA%;ͪ(Z P_~G`XZa4*" bޥ %-.Mܵ7j"hv-SrYͯi\| zGdOfMHpMR˳V* jY"ni@,hJ6v2(fmAS.[@u-\lЍ"W`hZrv EMDEOKalFL-Š/+(k&] ݛ ɨ- )=Iݒve.f8ų4dD4`W(̴iLV49(cVʭŋ̌e+I#$@(Lw,Lܚ-S3 +*j<`_*\Z 'X-܀HS5"/f0Zȡz{ۼ2HvLق ΛDZZ…Pe 2j17q)fd&@ܻc/Ұ ̣W'" Qr ITw!|rN \ZȌ[SD'Xq-XPڳFuTZPͪa++nK'̵9/`hTC2}b#CPKV /}VAwW)ؕ%ڮc"j$lثw @F>%>:E]jRRr-};ʵbN`mX+6f 4.nD5e ʦmMZi\,X*ْ mbI-32P|rlTQl JW2FV~bQn'" (6Of>! ["Q]T˲"ԄeP i6d`LdEȀ((T);Rظ2}dL/BfZpW E6̣5ԔX*1#eSi,$sjwд}P@ ¦S$#hY1 b}*# T{j;i\ /.ʰ VAeȖPJ^#h^/gZ>E ^V-"y@/>z=`_"{2jEc%I eh."4udJp̫D rbi2ڊe zz]. B(d1$+v&FQN(_f BNԋlj'eS]xch/ѕȣΣF%1$ٖD{(̑e'!2JqYyT/efI\Р@$v^ٕuw"MOWnc"-R7I9/+=bn@S `ZdFnN,e P,]5=_&QmPMO{wjE t% Q6U!ŢΥ"I ȓ 8+՟ ]bm}2X$Y P*k(RRr&w܉,ؕ fXReVt!i*TWMp2m_D,*@d4eKKp mv){Qp9Jl;@Q\3-J؈9v*LfhĴ&` YZBVe\JNDYYV@@5HW0iKZ"9hJIQr%̹SV|@ fQأwKNEw`]T= DX!2>$9,J%+c| ܲkNF"bpȃ#U̴i%m J.FH%Q)*Dfe JV`^ky啖\ ԆmeQ2BYъqD=eм_YKSVIV/˼ezm-`(lG(IZ.P5TPeY[(c'2j0]G&J`RxLwr`;vcDJ4[Cb rl=5cwҞb5vIYcJD*_֏5!BbL՘/-"B7I'dQ+z-M]>efL1fH4Qܙ˲xM#P72F.[Ek.ڦcuF &@#UwF&Ȃy/9[mej>E D2N)ʻM kk#v3|$'P;>$Q}=(JɢꢠɢW;I@>E\  U/} U/@H=bzA:,=eE.ȥFDe.N;̾L" +r-m`BYKw- Y Z684J]@z1p2]5}c܉8`De% Jb@m"@8d(dQYS|%nZڐTs7Lܕ5L*{1-V7 g6ʒ[*@uN:mFXr{9A:1ƒ["d hę%sv-Fc&2˺zP4gяcQR%1-xz"`WrfeKӗ BdcDT :%Ew`MM3{lUIp.nFIĕd.1ƓfEcrl(fv1NOS#]b2Kn_"㬶;ọy@hd_^x efJ̮ajjR TVT3AV15ba,>Τ'XR{,ܣ 2eMfG(NV)+;-l8W؋F>%\ " :fK 6e>heNLӾ PesE4P& tRyRU,4Z-Ot3%̋E2Ee qhPy@5bʣD$ZؤjzkP SWd=KZ23(lCvn+2J-x]QD mJnB0 6]Bڱ'DE7wH,F2yXZUVeb̵USJzP;QY (淑[yN2lZn{VDܓvӼu].+B/t * ԏ2f,9+"/+K:#D ߠ̣(\sُW'"pFʂу5T#,i%uE`.!@*ջnUocw7BU@-9vW6F>!T ڔӎVT{j ôQ^k2 @ery]A*Հ5 ȉԄ` fh<-:m$dulZ+īm"*=H[SppTve FYA [0X@Yh!R3H4৪15bОS$:0ZA(Z!lةc T>c:{SK RJjUwa<9_W}@4A*m;2*nPqȞ _PRex$a JnEKFFX@idҚ!Ź@ҪU"ѧ͐hH!Gr@=ReSh"0rQkLI`Xa fxcc^$0L}BH @@@2][ W+jUE^k:199);)%ꢦZL"@edZ,mW3w-};ʵ`H+%;D%˼,ﶼPNŦB|0@+iCTߐ(dndn<#Ty[vcnꠐU% 39рB&,MMʢ=`pT=ʖݙ*"[ES\gMbThMĆ@UQq5Qu`^E]6GvBmdŔ2Jn)/t ]QݖKUIs1ݙ}XD&@@XRpfv\ƒ[) d(bwdefn>3(l'HH[(]P"@Ӽ/"xCa"* %2i2jw@IYMٗ/Юh`-Ys1lg},>ztM@ҹVTYP"~:[̣V 'ZE/Kp\@^%h,^[!%0^c &5a̮Ed!0 GVɺ- 3lc20XRb2>ЋL n@RSѕ\H-`T\)eES6')a/O{+VcIk:/Q;,=e@+vZB IeХGvP OfCRSh /2b eMȠ$".T/s̶b/OK֑%w=v"GV{2Vn%v -SK/;vMGIZѕsrY!Զ|5`3RzRvd\ eV(Z)%;r#ϼ$yQ+JYtZʣe@.(p6LgȢv2Bm `tB|,)[|*UZ,yfDY7d"3ĭ= f"V^SWdؼ2UvF]A@E M@Twe(p};;Z0䣰Hz ; h'"a+?0Of> FG{9#Fу5T̑E`#KPrCm.DΞẹW'"PU}ʹ CVveUEȶU"*G^F2c,N`ȔrU7Y]l"̪-إ|ʖء2c,ic^D7#%]$* sˢ&Inr*R6crlE 2uj*Y%0v㦆6Yz҂ z|y켊 r-vr#D&B7% g};*ȗXfZ[3L*OT["/ }J1=I{UJswKs 7Fr%j@O)Sc 0]L7@MGv^ФfJ[:&5az @%:jZ$)l*lG@IȋUYTeӲhd/ KY#21UCg)!%-O*ZY^z$Ƞ$jn̉+2a"{JvdVeQz8*IrJibm2i2TIp @^z B`@ e6/xE =ŚNwȄ:Z$5":\ RK.Z'R7*YIw/SewU5VZ&4RRr*(ZJ6v"; ƚEJت1JnE@,ZTDID]vъXlP der3w@ND%pLw'Vylb[@[^B endstream endobj 2925 0 obj <> endobj 2926 0 obj <>stream application/pdf Print_200x280 2023-09-05T11:46:24+03:00 2023-09-05T11:46:24+03:00 2023-09-05T11:46:24+04:00 Adobe Illustrator 27.6 (Windows) uuid:7e0db113-a554-4c3d-bd23-117a4af26366 xmp.did:49029646-6567-0940-a925-6fe17ceefdbf uuid:5D20892493BFDB11914A8590D31508C8 proof:pdf 1 uuid:265584ce-6b89-4708-92d8-fc73ce2abfd5 xmp.did:1eb8a2b3-49e5-6e4c-9e9c-f67b70276c34 uuid:5D20892493BFDB11914A8590D31508C8 default saved xmp.iid:1eb8a2b3-49e5-6e4c-9e9c-f67b70276c34 2023-09-05T11:43:15+03:00 Adobe Illustrator 27.6 (Windows) / saved xmp.iid:49029646-6567-0940-a925-6fe17ceefdbf 2023-09-05T11:46:12+03:00 Adobe Illustrator 27.6 (Windows) / Print Adobe Illustrator False False 1 200.000000 280.000000 Millimeters Cyan Magenta Yellow Black Default Swatch Group 0 White CMYK PROCESS 0.000000 0.000000 0.000000 0.000000 Black CMYK PROCESS 0.000000 0.000000 0.000000 100.000000 CMYK Red CMYK PROCESS 0.000000 100.000000 100.000000 0.000000 CMYK Yellow CMYK PROCESS 0.000000 0.000000 100.000000 0.000000 CMYK Green CMYK PROCESS 100.000000 0.000000 100.000000 0.000000 CMYK Cyan CMYK PROCESS 100.000000 0.000000 0.000000 0.000000 CMYK Blue CMYK PROCESS 100.000000 100.000000 0.000000 0.000000 CMYK Magenta CMYK PROCESS 0.000000 100.000000 0.000000 0.000000 C=15 M=100 Y=90 K=10 CMYK PROCESS 15.000000 100.000000 90.000000 10.000000 C=0 M=90 Y=85 K=0 CMYK PROCESS 0.000000 90.000000 85.000000 0.000000 C=0 M=80 Y=95 K=0 CMYK PROCESS 0.000000 80.000000 95.000000 0.000000 C=0 M=50 Y=100 K=0 CMYK PROCESS 0.000000 50.000000 100.000000 0.000000 C=0 M=35 Y=85 K=0 CMYK PROCESS 0.000000 35.000000 85.000000 0.000000 C=5 M=0 Y=90 K=0 CMYK PROCESS 5.000000 0.000000 90.000000 0.000000 C=20 M=0 Y=100 K=0 CMYK PROCESS 20.000000 0.000000 100.000000 0.000000 C=50 M=0 Y=100 K=0 CMYK PROCESS 50.000000 0.000000 100.000000 0.000000 C=75 M=0 Y=100 K=0 CMYK PROCESS 75.000000 0.000000 100.000000 0.000000 C=85 M=10 Y=100 K=10 CMYK PROCESS 85.000000 10.000000 100.000000 10.000000 C=90 M=30 Y=95 K=30 CMYK PROCESS 90.000000 30.000000 95.000000 30.000000 C=75 M=0 Y=75 K=0 CMYK PROCESS 75.000000 0.000000 75.000000 0.000000 C=80 M=10 Y=45 K=0 CMYK PROCESS 80.000000 10.000000 45.000000 0.000000 C=70 M=15 Y=0 K=0 CMYK PROCESS 70.000000 15.000000 0.000000 0.000000 C=85 M=50 Y=0 K=0 CMYK PROCESS 85.000000 50.000000 0.000000 0.000000 C=100 M=95 Y=5 K=0 CMYK PROCESS 100.000000 95.000000 5.000000 0.000000 C=100 M=100 Y=25 K=25 CMYK PROCESS 100.000000 100.000000 25.000000 25.000000 C=75 M=100 Y=0 K=0 CMYK PROCESS 75.000000 100.000000 0.000000 0.000000 C=50 M=100 Y=0 K=0 CMYK PROCESS 50.000000 100.000000 0.000000 0.000000 C=35 M=100 Y=35 K=10 CMYK PROCESS 35.000000 100.000000 35.000000 10.000000 C=10 M=100 Y=50 K=0 CMYK PROCESS 10.000000 100.000000 50.000000 0.000000 C=0 M=95 Y=20 K=0 CMYK PROCESS 0.000000 95.000000 20.000000 0.000000 C=25 M=25 Y=40 K=0 CMYK PROCESS 25.000000 25.000000 40.000000 0.000000 C=40 M=45 Y=50 K=5 CMYK PROCESS 40.000000 45.000000 50.000000 5.000000 C=50 M=50 Y=60 K=25 CMYK PROCESS 50.000000 50.000000 60.000000 25.000000 C=55 M=60 Y=65 K=40 CMYK PROCESS 55.000000 60.000000 65.000000 40.000000 C=25 M=40 Y=65 K=0 CMYK PROCESS 25.000000 40.000000 65.000000 0.000000 C=30 M=50 Y=75 K=10 CMYK PROCESS 30.000000 50.000000 75.000000 10.000000 C=35 M=60 Y=80 K=25 CMYK PROCESS 35.000000 60.000000 80.000000 25.000000 C=40 M=65 Y=90 K=35 CMYK PROCESS 40.000000 65.000000 90.000000 35.000000 C=40 M=70 Y=100 K=50 CMYK PROCESS 40.000000 70.000000 100.000000 50.000000 C=50 M=70 Y=80 K=70 CMYK PROCESS 50.000000 70.000000 80.000000 70.000000 C=61 M=53 Y=50 K=48 PROCESS 100.000000 CMYK 61.318374 52.971691 50.496680 48.303959 C=79 M=29 Y=2 K=0 PROCESS 100.000000 CMYK 78.554970 28.943312 1.669337 0.024414 R=30 G=30 B=30 PROCESS 100.000000 CMYK 74.837869 65.377277 60.064083 80.074763 C=98 M=56 Y=25 K=47 PROCESS 100.000000 CMYK 97.656250 55.859375 24.609375 47.000000 Grays 1 C=0 M=0 Y=0 K=100 CMYK PROCESS 0.000000 0.000000 0.000000 100.000000 C=0 M=0 Y=0 K=90 CMYK PROCESS 0.000000 0.000000 0.000000 89.999400 C=0 M=0 Y=0 K=80 CMYK PROCESS 0.000000 0.000000 0.000000 79.998800 C=0 M=0 Y=0 K=70 CMYK PROCESS 0.000000 0.000000 0.000000 69.999700 C=0 M=0 Y=0 K=60 CMYK PROCESS 0.000000 0.000000 0.000000 59.999100 C=0 M=0 Y=0 K=50 CMYK PROCESS 0.000000 0.000000 0.000000 50.000000 C=0 M=0 Y=0 K=40 CMYK PROCESS 0.000000 0.000000 0.000000 39.999400 C=0 M=0 Y=0 K=30 CMYK PROCESS 0.000000 0.000000 0.000000 29.998800 C=0 M=0 Y=0 K=20 CMYK PROCESS 0.000000 0.000000 0.000000 19.999700 C=0 M=0 Y=0 K=10 CMYK PROCESS 0.000000 0.000000 0.000000 9.999100 C=0 M=0 Y=0 K=5 CMYK PROCESS 0.000000 0.000000 0.000000 4.998800 Brights 1 C=0 M=100 Y=100 K=0 CMYK PROCESS 0.000000 100.000000 100.000000 0.000000 C=0 M=75 Y=100 K=0 CMYK PROCESS 0.000000 75.000000 100.000000 0.000000 C=0 M=10 Y=95 K=0 CMYK PROCESS 0.000000 10.000000 95.000000 0.000000 C=85 M=10 Y=100 K=0 CMYK PROCESS 85.000000 10.000000 100.000000 0.000000 C=100 M=90 Y=0 K=0 CMYK PROCESS 100.000000 90.000000 0.000000 0.000000 C=60 M=90 Y=0 K=0 CMYK PROCESS 60.000000 90.000000 0.003100 0.003100 Adobe PDF library 17.00 False PDF/X-1:2001 PDF/X-1:2001 PDF/X-1a:2001 endstream endobj 2927 0 obj <>stream HlV lgn{wwg^91>GcuMJk)v0b[\l;&A!MiK ´D-)npn@)"ꚶJB+C , |֏fg,Pߊſu Gַ6u$Gqݰ~PϹk?xIMm[͌ҹ'{37ѴqÿQ߄c%M8ߍMv6Eqmٺ|4'ohmі>N =غsbWomqMƶcnc@exct"Rh?,?Zd!9hNѪi 냣v+ ]p83c1s;ۃ$ҋBM_ΟJ?BRLiJF jH2*頰Tl6Q,i$Z4mi5 LMć)16Tjl4Ea-U?rNC:.yIyR73yWe>om]-'ݶӱG8$.y+_Y8(`zj!+96-M%fuHFNnqS$*Uɸhf55Lt [W%AZnM VUEVD` SS?`1lo7Tx;O%kW {ia:dǁO>uuuӪ;a*C,ef:nBKˌZ8w(4tocv쉮'^Z##OWSz!GRov4-wx v1&;CX< d fy*I1rj-7s/; Z$(\ʬN@Bh5nJ(6tv-88}>7TG1tٙ.x6H*k0Evvʬr@7W$YYlM4D?eEeTB0584hHعn؜.Zt1U f5Yl71V3{̚ix11a?' [/į+uj{ӹsywקqѠYr|րBA-AЉ '0U.ϡPIV2 diq<";Nl_.L"Ӕ5$тa.HT+%|fZVqYJEQ%Bj=^\aJR 2r¥E[pBR1ȉJiւ__~{{x|]b.w>5 XHM221田y='Q&`ʪCqe9?#>_UB#aH 3(@啕xa0crB= .UwRi}TfŽ!yӽ[~*Ή".W 3H6zǣ{!\89pvԇhxzE|h8g8g6ώ0>|˞)ARɳ͞  oM+2fkzgπQF#?aX,zى0cig B\EuȈ#ϡt%_z< QQEU4_=s+o&vn8/0,+V.&mZ%"A% M ѵ"@<Ԕ.qS- iA;Z!FRˤ8;׹6iZ_{=~(z)Pn@Xeʔ:0l ;Nm/vζDomҼ7y mown9>Dmj_pD}wυ?|PG0vԶ8k@,X‘b GmfOMwg=3&mMvU/z1N~]`Ob-t5#dJ,YNچܐЌ16,u7 ֲà!JV [,YZNnEnsYLEOHJ*iy PWp:9wD*H2*P|gr'fl|FDl 3OćruYfEi&'gD=""Ye.Za YQiל84G%a]V)//KyRh RwQҥx6}XRHp Y@j#ĥsD epTF)< Uo# YdlNaC`B"4)`bÂ9q2ia>t"}O0_oP>+seSl) كR% 0fQj)u|&#3A Q`)`H pE`tÜ"|(oH\!%D#]ۆpak-'{Ontw?8*5r@|ٛ=}w/ALSocs 06@Uߒ,-rU%%g-o`tU=BQq$)4y\hӔ6ӍF1\e{wGoXkm9?BepM` w))06G@DRaޙHzө H5ϒ0q u/nY|)ٛ"S+|M'1Lar,^ C ];Zb)ܜB,oTYMVXDNMVvGǯp*mŀoR 5ǿۮ?&ﾾ~=K7O15KJ+w-?t;v>qӧѯr.6 (;@h?K I4-5 =l7O7RauޒK1|nⴋB*ڢ~,{ ^+2Xmr z'9xpI9E>^>hu45^ԥɾ`CDVK*s*6|ցg#"  .ȇbߤQt|rEn9U"(>,0YU_5q|tMϏC#-T+N'O gwJYYTx(na6[]`'a/:nn7%X4h)}ZzNm;2"A"mD* @ %$xOo}T`MC:A5 AAum &FJekg[ÿ靌) ywl$l2+2MUHNlC+hEs%D~\LdA!" V,DqBØz6Q-_xмvح[ɱ}v7~yǪ-]≾ΎkU?>sd /XRm]&ּ kӝӤRu"w/Zb'ObKD)'͌8Ukx`ȉ⨁Bv{$+#[F6q7{u/-b2.i3H^H/Yf'ҾXvG dxYޜݮdRxNf~ 9ЏMoRj ߀sUO-KaO\suF0914s¹45l^;V .(h2] i%Ftt\xl3 ZSdV'8=τ*-7Tz(·^",NS[!_ٲby9pٵC7v_۸#p7׳fh$[Ɂ?9؃/h?MZp~ j8D>@r xn0-a„ &L0a„ &L0a„ &L0a„ &L0a„ &L;eő 1F]w7*qM#Jx"^x+1(Q{F8q`fq7?̿Ͼ|گ>8hb谨_~5"zd̨G;N8iﾟ:-6n3gΚ=gnBbҼ) .Z$u+`5k3֭߰Ѷiܶ;vڽgovξ:|18w"gΞ;_XK.^|];n>ѮVtiɺ~\כr \r|_~?O'3jH됗mi|MyRƼj$,8CᥠލB>o- w+\UsQEE}ukV!z\]5bVof~GM.^^SfdJQl kra&7R̂dHհփ$g"x?p9I9+(H X0@P C &Rn-62e iIL%ݭօn=U!2! AuȖ\>ȇ_+|@ԀP jC >4Ǡ!10^` 0&dO0 [qnB wN܅q}A<cxOI< xNjx /ׂ\7&"w.L:1..KR4>"\]Fi2%&_ty]A4 ($HWԕtL1TJR)*Me(R9*O(Ҩ"UtJIYTS6**ՠTjSK>5Ǩ!5ǩЙԄ zSK)ZPKש lOm-ԁ:R'L]+uԃzR/ $Q:IyZJ*ݤK^E hR49B~ԟ@DO3, !4Hh8ߠ'I9zL/ЋLWflsȧMX K`),7-X+`%[\ķ~U:n 7-|~}??$]*K*p1wde5QMVij*P|P-U˓X}>W_jڠ6կ-4&pE]j:SꜺ.pu7mH?>?wIw܇)G RQZgD7Of\[ֺ&[J3z/WT zҚg9z^%z~KemJ?_uI}Mަ U C}Bg}Y_E~d 1)nJ &T0idMaLucjڪkFy43&OiaZVicښv`:Nbnaz^&6}˫yQVgf}o+~g_?¦~3?o;|?G##Lx!^ 7;qEOH| O Y#_7[6OlFF磗_hn<$__GcxZ<=-ijxn1''G[mvPH``0W{{z`zPxxA\vcwG䍼DAP(Dp<22TTva!ê*Uٮ믿W?|`N`n x i5}Bi -gV&el9{MlqhgXF`|߸6:9V2JF5:]U"jQQ5NyFW#(0ʍ cQi 3 "1d 6nn2HLfrS)Mf#Llj*3`f3{=fsle636f80ޤg ^OGPOMA!6?ˏ~i?s*!ɴFV\Jӌյ4ͩni~^@itUh}W ) ;JԚ62Tx&ݚւtF(:s;v;S;! u`7;դeK0ם;1yxqDџ*/x4f\nĿxKO,YlȋUAD{zHYޏN[W嶇$ln޿趬ÝO‹V&bOVDz>' Yt}.gU_ݪXm,9ζux0YѨUSLXvŽOyaG:]SOZؘH &5>v` B5Īkk:w멊ŭ>H(!Q+ltUɉm׆tPiFBvma%l۲Ǎa;lEoq#un F} [e6:ח`ƊU}soycp6ޗwӨI~׹q?27VgKIRj"|}i2$wysҤ',kQoLz9u| "55LZkԊȹۧ"wǐߛ~,B/w]êWhnǨ%=Bh yb؇ `]ԕ6+ ;~jZ9t#`!"V:RԱbg}sS{+VN}-oN3 ]#Fj|pp(vBMY+6EMΫ.B#gkh?,9)slLմuϚkf{=HݜzR31zަS;c,Ϝw`0x+/|tqT{{Zfޢ ,uec< X,@ ,,e{x~Rlvh_;M#ٴ!f R%,Z~QжkIEf쇬=6ujN+WP-Mz~%xHtS̥r~%m@d$]dYS4eaii^bv VN#7uކghxO+:nqCqw&z'L υr|Qn;ayMo⛕AolVvv990YhG=}m,{N+t5A2Y'֋"3X6MB&ak_ב߱|x>In|)_wW'B#-bX%^şE񥸁hvZ{-[izmvY,GPo{ FxʭsQb1ny5 Qe'ocTm߻ )Iia`pl)i~^ՎP ZejiX[MCU{69PMuʤ2M?L>w6M߽}߻2p.e6׿Nh?Vȼnsi ǪjؗU5t02c;{:6@0C݈m" 0{~“D"ԅ~(E9zn"Owو9Fߤu^AV<8/W|Bvcn#[Ɍ"z5^1k cy+Ƒpt<12 EQhC'fWPU}u`G/"ꄉ@B{.W<2TwPz0F ߦ&ԃS^ɻ|!{$B_x;ʖ6z|hsl7U/$A7ʿv*sK:^-`!/ -Qu21da(-otxkpѮ-mڲyϮ[Cklj~` ѕ3{}뭺eKk,^psjff5&E*mˆ4M  23i˧LUH;J88g猗9YDۅgC=h-oN=8\:nK2ԸLC]nv(!Fʅfc8#Y+&sM8`RN'2Ѯf h23"{dM%bX*4 %Yڌ=VCg\Ul>LX͈qq1mOXz Lexɥ=-83v],^ ‰}6#IJԪ¤r*ƽilM'xb]]|GK^#"r%L{}ny/-*)M|߱󊃚93eiv5-{6fYF6 ?AJ`G&D (hXmBTb2ELU4|PI9@/e,&WV!Rbm^T 1} fܖ5p$6L>NT6 [)&JV%E*QiHL f 6y% --Q':{;饋쯀|zsVɅ ǰxq-CS{ pjSz$_DTj S2P$ )[bpk\1qvy^P v;D<;;!iœ/\mV͵d.K(ğ*Vq⧢1By)a4M&ӥd _F(7## 3q+`C+BDD8XKj"F;ݓ}Ct!Dz[ 3mX [<8єlK8F"w\!8/߉6[6# u+metmfV:{5:ϦrqkZk-rNS8\P{``ȹFЯت~b3sH&bN :jB3ȶLıZ#@ iZ)G]ϳJvߊɕS%^1qK=Sv+h lzGO?9}ҾQo7xpqֻZf ӇSw}*lUP&Ŏ!#P zlVqPI2L ʽpk bEO_OUe0(2蔍<,fݢE oS-cgf0E7Y lg:=usf \$*T&0((RˑSvڵӨ!ζl@oIdTӍ.AԶYl_fT*UWs41;s$Y'Cb4foU 3Quۧ.vQڬ`QK86^YOc|ogo{Q̆`u)[ou't(ȅ"qVT1B^? XnouF?b>sPk՗]bc6zR D;8RȢw(Qa0n@tJG.mMj<ؼMVPaWΛ S,3bmw(;oy:LE|7\UM QZQ$!~Nf,:[_Q@ mۉAS0x,tL*=?JCt(/>sL)@0@2^D[0GMQ㌓ -Bc `Mb #l2p26ݢ"ɔm XXi>[ނLMs[4^ A lR:2"cc|_D[ <y+7<|LVIe>yք"Ͳ]u,XNx2NPhDCPwXYBĐ2J3r9=Ç@_0)c9csR ruO)5np4(a;RR tR5Ip^{U`yzN@^٨2bYl6̷jQye7D_jJ. 4 kY9 ^gES2p-c>}+h{W1:vX1K-}8w`rUB5| @-(t0u]k،ڦlk lj5>S>5K}uNYtͭ>6Rk>զZ3e`}ۊX"SfU\!Op#+rChGgIs.%la~_5  wsZfex"٘Xfg>hMcSHN ELO@1cpbCFibH"gL d9ڋw[]7(.s#+84rNHB燿fG-Ek56c!qÎc=47h| V>ȋ>cv$f]vg[h5i8q&O;;cGe^ׇ(DB'sslnv??/Y<֚S-a>Tt7Rƛ3ͣVL,wbwK胜'zFY>z#` k5/hNtsΚ}zAǎl/emTemHZL]>TG䚌\D0?Ot{څ-ѳH.$6;>:V;@QgŽQֳ`N?Wfz+9dl\/2Pua\OW%#Mn=y2Ψ^8R&c+e=qX,R#Nڞ㻫'ګiױZh,~u VP*2s+e\Lq38vc+t]s )fS2өz|ս]'05]6Of &`WJv%o}~Y L[ ~}Kstxk@lp@9f[,T%'hb '\ ݞNiX>/\Npպ]-l0ܞG!8 'NH6"w3'`cLZq9~˲ :UarUʷWf[;'7U'lp@[ٿC(~SsU>N׎F(w^@Q2Ih=Wwc{t?ѽFcr<φ #NٸۢXr>1q9kZ VAWMOH}r4K.?"Iٻelھ thoL!pL/֕=hi86#ovj|oDsJoO@>o3 2)W O#, nVh=?3K\)S,B>?stp_# %rgzowϧD}Ԕ]ZVg[?ll˺"9O֯Z;k g)BV0oY]AKs#da7S ccRBpܕE;D=E rZ[vrg-w4G^EN ˵G94E<wy<!VS$ x]ڦhGn;:,HELOيuoa}\G:B30ւ3zrTɌ!WbJ<:Q%}(iϞv93Ue ]?$ku? Ιc VˣArr8&n6WN`1N!h} 6<,SF<ԴHVT;ɡ}^J\uR<Fs<8|usFs;DgNJNý&G?TjΣm/Mf`-Ljm_ON)/mlhzbgV߻;V-r>i޶~[;Gv~D؆v`Iށܸڭ)V_EkdtUOYg];[G!I\SI'6 `Ke1[~#o `0=6r,u1e9ۢph'kj!In,RE2D͖RѕR~]l 9>+KuD{iߩ bGٳ0ތÂ`(z dYʐu,*U#B>~ /Sf6GC{X#mI+mu0>z0ځU7ZdEx,L5*hqcGa>X;[7̺S>.(a9gɺ1岎KR=oq]+Mѝ^9 gqltݕ/Ѣ 2 OLww|>&2re{ѵ60u/YG;򶎶=W_A=C/֩FZmt9?uڌ-TOv˱wt{{h{n_Gĺ>ac]ןy6䦊{׻D(r-2pϵ/l)lKyR8WS:QV_0Eo!=?%4u|IRq2~:^J o'|ނZXe_{fGŐV+Zd۪c}dǕ^ *QRi ~G/0E%r C "}w^D]* F T}N M*h_O~7Mr""s1zp"{ d$ýW; [A^N5孜~P0ұԢj%m<8lݦ%|Ϧ_)( =Gvn|/~)mRz4IdtĹ>9;!^p:{7V0;2[8d? sdXx}}9;\Gʐh"ql\+E`~rsNv1"iR^aD:l#LKlKow'wp"Ѷ=/41vǗd↢r2*;8~Ex-|T.Z:}ogM.j;GYA|Ǻ3 UaۨY~)Y_YVNvtq9H"6c*ڙ a~97q?hT\NՔ;Ɉ.h==b朧OxE4.qS{ԏTY_}]vFE6BwA==Y w9e沫}FJaDgroZZ>Ժq+D[ZHQM}Z'XPtuނ\a}ʸR/i_E+{ۜl3bW? 0ef}oY nߛW;Zӗfwa_lmrF!-zU't$ebȽ$+#CHWˋE嚶 Ѭl1Ė2ܘAN#6JSs[_c-$6ٵh֠$jڛ='V v}㨴ΠȦ]fF2d҃'^].-jJl!o'wZ0qV4z0DʿSVZ.lɫor;(' |mi i9o~OOxD6x$aD)7qM`Eٜ/Λ}}_1ڄlk/}͞F)"d;xgDU^CKK;{~2ŔkUҧ;ڕ9]YxJuX3gvmhco~7MEkU*γ>zN9eafvam|v:|㝹FAIgXH\K?z#e9%˭iƄU/aܭQB>gYPuXoB&72Bw6r-t~s|sܦnf 1DZPs̕ ).D'b),50Q ;1-ţwz:5˜k@5I1mO%, m3xγ]r}q(O9<ױ{^ƸIPp}۸~ 0ʗ)ah 2wJ?sˠmL#cSAӆc|ehC}Ed*aF[kyy$Xs:tQ;3|)>s#mhP``*8bb_3ya+lMwiƣZ{Rgb,(1o 㵱 a샪F[VrϪxM3LQUV)ߚ<;)Pzy>+ߦ_I)8y.Sǽor1C6Sl3NE7i璿h#uk4@ Ӈh.;ٜYM8/sNR(2Z=̩<j?ҴQ6r ,d_r3+च nS159~; pNͻ9M AK>#@_ZiEX+w:0Au#2T,]KCvU.NCߟܭrTF}]SCrJATU[AFbbdy_" H;Jm iQC}V00GtNJ%E=8j$jbvRRA^"䲮I꿧EY:5m('FhQY~/8o+s2"[-LUd*>Z|bJ{PW2@%7t.XݨL|W[.(74>qEg "b\֜(nkږ#.iJ)b*aV8Idꬁ Zi] Q ,ȅG$ZT磩3CJQ.=w=!a_;:SGgu`p~>%ϲu1`Xcl)?"I  G!j ?0!l}6ȮûήkrS1-'ZΎJ]Q:4fԲ ==N[~ek1]%6Гh*рa`x, [O5bÀwЌˮ8zg{wdF]{`o5['I y2!'l'x̰I  c+yQ2YC>+B'Ԅ=f^י_9./0~ O{g 46O}h~f7xz)el4Q(/'}ׇdDuZ/QkZguZuZTjEeRkPX|˃fZkzZUjJPZM.9/ />AÈ0cXV` yeB4_ eJ=gWV'hh l.@A݃IM`x|;#Ot!Vq3C9t(ڈ4’T:]ھUj'l]`sbfϷxιїykl#0A GT*8P,Mosep.h:ψIWA-ݥ%MJ5)=%Tj&WqeQ}?InVQϨj( FCgwx7K_1?w+a%t(w+E)^)D6MC|FB|^a1aY+(S>stream HlV p~;Iw-K"x4l CDuiiO (O(6Ji Sd@nLRQ֙̄v И0C lSnnjw߷}>;vK֯ p= .o{~UO^t sq,~bY> y UW߈߇{U^_q-4mνߋW5ЖqPiղ'^pmͲC7o_P@xoD/S] R7 (?@g2~x#p|$>K׎!~BИ  ؔK ìS/GJl"N84ӹq'7%GA@7$ N7(-k ajL޹:!Wڅ[7O+Hfn/KKν=dB"Zo!RTVt.aRp]p{ΑuZ.242>1B뜎up%)#w18w̓VLVqk2s5Qﹽ;ȕۙ26{ S3Ȼ w *HܪiMٔR:7J@<!LPYiY|Ehnc(BdN)4bFanAI:Nveɞ}4ʐҠR[A"VL9fpqJBP?@ΆFX [ z>h?4>2H W5Db OG*6%#JgsWWptZ_wM Iѕty_mh-E E@Bm $,+vLKqO)̭%$ݍF9VRF 9[{N&1Ӹ$fy4 B]cs [4A^ jZ޴ &**(+M=Z>O_^iWJ7q"[Rg=*kY߃%9KA^:LLyE|7K%f zFvqWB??F *!c]@#i筕¢ɥY\rCU1 >j4 zc-}+ЏPzv} bde$!yN?eY%|z|\8b!]-hdE$a4]rDž&ݺ'V^a Xp}ǺVz۴ر͛f&i?ɴL&ǓΒ73z +ow*rL!ưN eq4,,:,bL#8,UԜ%` Tϓ8yF>Ѻȫ&F5 $񘷮|ɢ)2Qe넫U FEi 1z_ꦂ=}%\[Ul4&(ðۦhs j _T)ڃPnP*@(h`k/3 UZMiq?LM9݁KnuyYޘ?rf>#\{wm7uY]~ǯ^uӠDrm?Gഠ;gHo7 X'ܕ`Dh)1=ogB[g\U $5ZZ-_4BRoΘzj#!eu20\2uk'5)/"JtM/?=AιïO/|柿އN.8{xGS2>{ #d*ayM_oLDRRhNT`HS>#ҙCR GopU'Xrq3︪r0~ Gm|c}>E_=mC6mg+G4Ůj^"0"x;KUsyyz|t)#:iGxzʀkmchuLGG&IM$ [#L )z,oTuਮ2|νw޻lv7lɓDr(!$%!;@ X1AHa V:-R$(b)Ny:Ɍ eZ5N1δd?g.Ggl^e!8<1 *Qx%$iB#'k 5hNQ+#I@0BI;WA5Ht}N(ETyi_axTwq7kR00PN~s4dǁKWqcG} }u-zz>>~saPww`Ӌx=;$x@UeHt#Ȼ,?I{Y2& Ġ;Q/)o -F0F/xSrI/xݝMԘ5 F0EǴf-,,5kB# %:9Xc%X$g' n > `.pc̖QAв+DŇ4\ cFx-'T V C8*JJĨL &bz|pH .7C9@RoU&^-۶ݒR GNU"Lj}w:}6bq~$cĻ!M *"6&AUڨM+}kYDz^_rdbk68dCV$9NɊe*A4PYYSo sS sCGaހ B > #M˲k<5. A&?}ԴB5,5lѶB>.C s:GORlN7R x&|3]@gk! CсoF{|sszS.WO>յ߇7ҜY%90~M’qk;$QJTJA}3ZhHL-y͹_}p?ۑcg^t nip8A&OJc`*D̙-neȵ4T2ŴWlczx˔^D:fbkYp$BBHD[7j5LVQOUtkC6[&v'[] @ɸ-ػ.vXC9=yA3*fYAfw#RD&\!AJJ:ۺD,+r(@MӨ*a"9E ,S\SseLuCix Z1Uu:4}"megK mt]Ox<=S~]םl׀-j72FLo4%8%f/-HivOu6N?'ηDAt.\K$!+9xXU2$U#IrBi2⦌Q'P8@C1wI8Jiʉrp)|MR4Mi |Ltp۴nS5xb>{s={Ԯ/9N=VO{WV~gdt=.Gk)Oh1ql6rS1>SߋpN>8(fP6p&-z(*,OMMSS.LMtF}X[<,>/~OH4 5 Y, xQyh4Ȝ#P&-d⾁qbPsL\/nfZG5Bґ ;* 6Pm.jF`'M-jVOMI6ZZpW T`0JWWXHv|sqV~Q:,ݚ1\Լy{sޖ'=]Yrvw{zgjuD:LlwM0eh53]V $j@2n@Hù 1氦MKP[ 9_\ (Ĝ́*\' 9"98H bЎi840#EV7U9usn͋llH !&S) G*JZiS NL3cYG'XmJ nWL LD Dc,ypuE喋4 (NMr Xcqh\z˂yE%~3g𖏱'6G5m|;xS˲~SDySm˜;{z]v -.р^y??Xlj/꿭o>9S]qa&ƭ5Nxcf z TEe33j~p$j÷GluԼ4={T(#ݣa妛L2Y_K;MÛw&e9Iy.{Zcx3;s$-۽IcOf#+FD{%].ץ_kNF' *}øaްTMtMD0-*+6 #XiDHSD\" waIaY{GEԸLHƺ0"!E )+ oz1v!`ǶOyS!V([|grQ&ldeW!J&WR G}|+mɓɓmUw@[w "-Z- _gJZX[ɟ.* eL) 'h5cd P2p+ BYHd;vWѶڼ11f->,GM;@]X^<,"]bm~<EcU^ui _.U!8 /#՟ٮψjJ \\\TƄࠜp؏hܛ7ca{xFT6/_r2$pe2eO*ГSYX޵5ưu f`6ZFxx{ k l݋\Q4:`Q239{2T2}g@Q5cq=3IwZd2UPƁt&(>A84nF\-MJ?<dǹYKυs<A[؜؂g<1uv];FkM~C+<ֺki0\Q?Ev)Gj| `Z1oig¥,zCn5`s""\֠ZцP;.~bߘхЍ P,|ƌ.Hg }')]fmӉN+,;!M?8 ȸJN BvXTo6F@ig{NOtOF(8B3˗ _lMpi-d;5gۆ+w7COfCp}*-+t^8'TM%ʤ%L\3x5֎_#l'03lB}cZ7C0%m(UmvZ#DNDJ4tT^ӈ@uGw='0SXSM{ Ⱥ b|C/MLLB1ql0kLqzcFIZ/9'ɝWWU6V11&AYD%1S@Csaˇqo??$K}C/E7kɡzx>hn&`evR3E-̐p1ӒT Uu Qh̀mfW6q; mBq4$ǏۧOC-).A]2{('GpQGxm p-酝c"L4uPķv/HKVIzI!?LP|MUC,ҹރQXTWU٣Y l{@Ac5"[gk8e^΍#Yv4vf ?Jk|n fEU^͞ 0;S#EZFey5(%!V)ӧT\ /̜_«|=c8IpSL0KYK (HF3FB:)thNԢhRXƀ$#.B}m6j ڒn.#!|M绳sCke0ͮ쵉Rցw_\D*!>◐KvZ 2rh'^M`JY\XKWXVؖmڒUZoڿ<-B 6]nS;h)N0]yB|@w(yfg%SU%SUKQd/IS\|z?c*qX?g`X3yٔTY=]4qY2PO) Z7Oe gϼ ~'x~~mF?y;çA~F 8?̎O M' u*]tZ-vgIi^lU@Ԣ$2F0#׋i+V9/scpAR?+̎ ߰/g޿;*T6FaAh`YD9XeZ]V@3r%t6=詳3_{&rFT;6f''15N3`g`<҈qf7x|[x( (wH5\jqCQt` 4_Ck-te`G\O9nf?k6>kFkKś '_,=/SchkFlݗ XEz]gu>Ŕ[OT 559Y95 k2BKP>cl˞7w`TkU}!pWxPCV?N%nęl1ZI$dBvAmں2 9uĔY r<\޵[j=. s+q07nL?-:qE,W" ,smW$ ^1nKr:-: GOzk h`Zmt _iGuASy;@Ȥ+"…S#,bt9P8 ЫSbehoԒzJ@cMkJO iIp%535ZuqW''Kmןʳ![2Ǜi~}C8@ Vq8-LnX26G'Ѳ鰺VCZ_+?Z]l:WSK5zߡvoӷ2AivVѥae6y }sD͙?tWl~~>b~~I;M#E]i*mMN0U+T&J薪l0H쇒 MiH(6lc EP-%X!M}vb(Dʽ}>?>?tМgc&0lvU*+U3d)k,avS:tF*Y \5/RKT@ *JW5W=x4se.伏BYN!GԲ< N$PBR'4:*m0i.]P:z0uF"/ez-@ZIt Q0=8>#}.DE]%QW 7ՕH7+u=>sbL.$p۽|֫7?wux:gn_~؋f>?sX!zz3?v,s(а_32>1֥֧ԑCëéIE̥s@X iYDžR,JD-EEmbz gz`:+Ӵ1#Th)IP*yUi`nIcn[dᚃXjo{A eJ$ ep O%HMDYٹ{HUmB S1*-A;O+128M>̖_wjJٙT;ڱ[g2&]YXi0(A+3=FT}9+[c_vjrWPp^onmtO񞦝M塲yM{#Qؾfoao //7]/*~d ΍Fet6w|‰=ϝ= =qk ,g_xߜx1Ix6P"1uTPݷ.zz@5ŗ ,0XM#zz@|۾D%&d'aɇ햚f2 )ʤrUUd#J2螺,)jN/ATҤ{DJeKBd a2I:IfH\#BXc;mC*Q#.J|XU]+I%d>S;zK_'DY|J_tS%.B`zrllsj8i2E#-[%*>5 0YɾO= ;: _9**!z({/Km>U|P L,͎Fp(p"ڢ EVG𧻓ſS,E([VEiwn%w+'ɣsOtސG?#*"(%J `4&T$ĒԘ$*Ѓ0D@ D*H-`G-L!%r97Tge;=&` h#d=2[FQ#Sć g|8zo>q؇|X/>aÇ^ׯ>1fp`ji2g#/%3/*L^]YgiLƴN% XC`f0A9$KlM;(bE &!0!FP$y=1{F^AMzʙtv% 23eLp|6Lfʨl S w&̰PT R&)z\t9V+ZBB1H!!n_Z҇v&un&ŽOY:yf}'yۻ?t}U)H\c80<ݙًbc↋/5nvPHb` E#nT (%NKKGi\*E%h*ȕj98k{fv3{s:..U4+El="SH$W$Tò UB)Mp\n9.>ĭj-^,c nuxދmoǷo冧o,~f߿wfU3-o9޽G^k.C,(O)+:,*B~E_ϸKztbb,.aؤHnaZyx6LKg,`v,* Ċj LXɮs=<&(%Gn@flE9fh4i 4`Pŋ70|4"iE=Ǜf$fF~~It[}i~<_\n(7V`Htry}h,cBuZi}*t \=.CtpcT]EcNcf&HO½7 Cz_GI]OF!$K?8"|&q"PesS}~.b.s*O|Mh7Ṱؚy-iq[R ݅jm&9ED-̇ލ䇕c+oeF3NXOb w{Z8hrFbP2c@**NyI3 C ְp)^`?5J.1Nm;$4v BSdH,!Adž#aÑHDT2d  / " m<#s.ݿ͞Jg/(FE\$-g; $GJ M\> fKm%}^/zuݿ;s¦lF/<}T<}l4HǹxN*&mhF߆um_YʝƤA굏ϝ;{mR=mAɺܺ#O[b-瑳s`|>uL ;T%"QG#QGYiAq)l;59ɦkc\f)]..MzI'iuɀKIC>9&&O%GbR Պmj䱂ʄ3U,AA层doHK:l<V,(#ۯbqQnsŢa:/#R$.j)NX))PŌ:"ᆆ5،T[W Zufb,^s˖˾]KwFz>mW_&xG އեT̾v )INÓy~ފ~$$K:Z 4\ 驳M̪DV4]e)yx HKlN6)D帞ͤEGiŎp8L(GԳ|gq^;m}g[=J)q) /jŖoO)YIY&$DA4u U$7z 󴆓c' ~A'z&>$(2nBi&^J1#{}R%~~od|H֋L HwyY |^}~M;2m#< i퀡**[jUnV<J9>5ޏ 7O&ۦm|XFJv< ˄π$녪{6x8A`.h UU=Y Ѓ!1GPb iKm3ZwbZ}FһLP|bm3{41GwHU;35ǾX&{Q Y](uX,.6X[(P[IMň2hQj[iccM)ۂ&jiW;ϙGI̽w?J:k#u.Pd'٧aԞz=aw8KC3iuov7].ggpyƚ ] _5dvՍR;z2!Ԉ}\BQs gZ! :NMׂ96H]b/@I3IrɳI,x *W]b]ƋN-Ih'37+|5,:3Clr\X}8 f%j?3@vģf[yKA5h<_88](Y|]gv Kx޼z] O'湅ĉPjBgx5?>-Ӽ CӸ7Y=jxc޹+ ';[E[ %odak5W;&z`Ӄ[7;><d v*$hW?S<Tys?QA9P (6sh>w{ɯށҷHsԯh*hB QeY6x;o7gVQ)J D@|q  x^{~縰<|W@ ::5Lmod.*Gɭj@Bo]x>r\MSB?~@Xd"TD⧐q#އ{pwǼ#Ǩ؊p ~E@(qt *Ce,%\dCp~Gk~ ,j2w}0&AV3d ]/ȱHB![V›UX@K:<yyK<'gv/0xA|\x!KfulpI: SZ cbcc˵iaϵ`~,śx!LG C9&*)v*N1b"HH<)7с.໯,&}z֨Hmbl?V24;;+qw\ s$5EzJUE8- 2>Y(! s,0KXd+o[mPY2ȤJ~(N~^xu:k=au2ϨQkC<6c/vNקnnJ=@jmn*_ 9:Wץ7t/r?zcXTFBr `Eo:,nMd*n2Yʵng7i"Mr{sY0*łi7uDڣvt_f@g4_dn.r?OTV5dKk"i٢d'^,ʽJ:XjzHt80nKt#>_MdѦF#"i(Xuprnoia ͒agpZ2ON;v;%ﮜ۸:Do쵽~̲u -QBI& Q UHIӄ* i FP\(h*@+]z/l޻w`IoP]:2ǧd?6;.--Bd5p,ehuE;Ҙ쎃i\ 53ڠNZF6 V(&=7:MQ9K/~cϛ_pzNjw99s籧.V6Ӗi \X&dӶl!Юm)@|ǮDH ~,G@ OAbe,>NI<%a)x;D_-wca, *t syZ&:.I-ߏYCG: _G|"/p@ԇ>KBDjjJ\S)&%{* ;7-3MQE`s{' |5|#B$8u?q'JCoͧ^7grlOHH\Jt";6/NݍiҤ} n^'oXzIyw?~5檽w0ڄvYk %AفP\RVLIMlN?lqS7~)\Ʌ4 ^K!TAD]4o:bܤaz.|}>tM +v! T(]'H$CCK%=Ȏ&t=FM v|ćZ|d%iɤD1$HRQK-uG#+tר&Ŵ\O+ô8Ij5U:rheO|eK4 動ɓ6M^x̬|hg$!MԚLf f:\b42)3Zl6N3L CLO1tU5K ŃԊԚPW0 dLs^H fౘPv[/ +;B™VG&*NeB ^]U|W~c|Ԋ/鿂Xt]-0ճ_Ky4GyE7=UsVӸV*_P$)|$V S2}1z yOZd{eU;pQm-[;QML\廵d^QiOnsg-xJ 3jպ or2bpm@bq͜OeAFK^Vz2JgٮZ(Pljڟѝ́wek+ّu;;هw^ڻٔx1xkL0CKhԺKK&1 ]ISԆ T-DR-TèJBK=MԙΙٹw9{t}X^[J٪?ktolX ۰E懜ҏ!\dO1&g$`PНbH,$YB V~nq]@U -~_a蓳{/ُ~G }bv~/Ύ k'B#|FEngUWJ:=WAcaP⧿)9TP |LV.TqHx§D1^VH{M1}+3: wkHq3Ǯ87?w?'INhxsOFWyeӞo~sE~knvnB݊ Vj өo~ \"ܝ{ o|xߍj.=U5((@!_() )R!YXVVx0X,|RWDVD^I EN]PJ. M55MM LQ|x|G4Ʉm;kSLN: dʀ4ru'bGu<.9K]s٭뒚N44J.Ui+hfzӃa"a>OdV% ?L15@I`a@AA.zDJ4Oޖ'RDz"z#i6*\ vJi!XpV ]4Ci㧑A;J}8!|ƪnmM#FHT0嗊ZʋZjr Gv-XWA,]7ܐT + 10(lA2 h^v8}p;לo߹偃=b*zm_s9;KI8}=9+kg5_x,vKi<7Vʒ͢bIq{ ?yZѫjݒH,9=gq 8Nd 5 H>!B^;fZ!q,;WJ}"#*5Ufq5^^r|$Nct+T@@PȈ` y.}"%q$YV|CєCC)~!GJ,AZV1Wπ4yos14 ^ 8R!涠[I}Z, ReT)-cir7}9CO_zgpv}gKoI}㎳ ɽ.YWޞ_B+N V1[t/=5 OʁԴ~6Ӛ()eTQu2fQ6OsjdYw#2$¹$)\tW |BDW\1b09h2G̋b 0QqH5= x. OkeՀ")ݷp@K#7K{lYḱHE:!@8܇ O5(7$WUHRT\A uGGɿ>~4G5gd<'4Oҿ%"RДi md e䲚\n^tZ^5/?|r]u,oVO'3|A*_Ud#yH>岪AF!3P(dN~Y=X"D O7DMDCVCAbQ0OKX$IH H(zy1rGh\zEpC!5| ͥZiB.֚EIwoj#cOAW&}%%91FdWlZٌ$ts=a- wAGQtOml3/L5(j}1jCA"SWt,/=G jBWa7lZ){ľh$/gEp"VPBpAmIK.xКPr[l Cϑ:>2c[6o򀢫eJh9aZ{d]ggbOu|n۪e9 -Oƞ٩mUIo&?\%O1}=,hT&tlbMW"?B^dM~:>ˏ!r ' %*-E7M,;|I†q`R4G{6q{=wN'$ $ 4дu!+0JFQjY),kvVVicj׭2揁NeUI;MR" ><9S&9><2fH|- Ȋ nz4e -U$4ejC@稭jPxN~JUX jp|4>W83Dݏp텋>Ж.RRO|<2wЄOmv14] `^! ;;͌52 VҬ)w'ޛ@ĿU.}^S7ZiN,CPP#Y4y BE6"b9xeg:[..N i85qjp̋/,^۵Ylޓj̖--t=7uTvh; k- ڙE:5ՆALdyA@IJҭQNtP%-=D*p8:t,eѥR) Å&2vxa Ʈ-]V5]Hצ#8v"'6i9;`Zm~Q>S=d藖cuD0EPow<"ϟI͋)˖.fN#[smL\JBMWU9Y<9s~ָP#_SC,}C஭Ow ^oLvire?ز]ڱ9voqɹvqzqB߁m4}DB+k*\ (&i%4R9d&x.rnMGPOdx[$m{[XŶF46 k㚢/ AM$\ISPo sX QL%S+?ѹdw}9ݢ<=+E gk4C&Qf&>ibBeEL @}H5xFQt7INȆ";5gR-ZBonVXX]^Q&0{C,0 TB,,K$; y; nGMZkiX - [S'{aoyqd G|cS k6.b@\R1iKZ"+UP:C_VtPEO9!؀b\B$,S)wAx_+Dϑ.1q'H2B㉬ZDNZUQUILLR3 uRUڲLCD<`kHj);VURQ'iXR^SJok*" Q D3lP!lىWxpOa r]`XpCI`CYtr7MҙMQ[s3"g^}PUsn{ߺuwKn7Lv~57SߖwF-"SV8*;,Ic&ff༉'# mvDI,4J4.\oq{(oօ=V]>_:mn fV%uԀ6mxo\fpެ s== wbdxdHόLK<|1/hGѮ}Q!&u֥rwVcE( [vӽJe#dLIg+u:i0ɲhdXoN3B{U31ùAYԔ7!-g;ʘFZ&ˋ֋z!8׊wSjކG*l&8y6_t9~(>?)ܩX}ugrf٩)ͩmN# oKBݭIjuGڳw^m_k/ 99u|5[ rhv%݉^ڰO2M [k)c^g:8w:{J[JD˪! FhtX|t?7M$u>d,èX,`]%AY>\(V)ة;U1:+!vS|BhAK fT/eΩy3BQIsCړU_FOdsXh, ,eZ"TIV6&z;帍T⦑㛆nIϯA9io}!޷c^Av?iC}:aᝁS F`U[ ZZ9П0LN~x@Qzq-41kC]WSyƙ[c7WYOj|M%ܾiN3@sHelp2%]mڝOұn,x^C+¿B0A.t"h@Yce@CMVcx5@BBHa< #{`uc-Y_Xfe -}B0y|l]m =Lp8p8p8p8p8p8p8(:D}X1ց{40D>m3jt/`MA2augi)A1|ZU s@`TC c z@w3$!dRsiLgcF~ qhŲ> Sb67a KUX%X wt{?݇7} S-]f_ (aC{Ha]qGzu`K>c&*[GdA` - 3I\Fd~҇_#l4׍}iV҇LrGqΉJ'%lg**J:ʞ$?Ѻg/U:,"-3(Uٜ{?y̨'m=*iN&JT2ƒ*27'= iU3jz"6[ڕVאE)5F, '$\H2՟mTW4zHS8IFztA'A:R[O,CNɼXW< I~DAI&ٗή Uҗi븣,EDFE2JU]j4FI\+%Q5IRtl ♪Ǝsӱpz9s l:UWӽ$r[-b-ڡr7LWLl׫i3/CX6a;A޺[tzbDޅXۘH $wEbBqp B.úB3B?^ħRxr!g{$;Kӷx뿜Y+`/^cp$0X2kχ77a{ֽ6!(<آ;j̷ G [>J6+J ! K6@C` Y@ #<`*hȫ@z"> ԪؖZlHs*_ GOn3̽& B`3N5B%\kL%Djgl1^8o܁8H%̅vK#/N%fj|ū7N7bh6Cp q%w,{ imEl18ٕJh2u'c$p >FintB )O 6&2S0, ;8(6%[q)O q>wŞ"y+F&\Tq&|ЊHj74Et1fc|8$n[\6ҎdK 񔩊?an6Į8o R֏w7!0KaÕǝ؎s6y( )Zeyy;-#X%ć5 2;p\E/v$OfBë7ی.Ҙ #"S:Hα/<>q?_@QmH+"UtpVW!iYs'D6F#G"-H=L%BE$in& 6.312sq!,½IBCA1dz!јdcXN Fmg- 8ޏ'L>W_—f.{o*KbX1T !&9b-kJrFkyܲjG| kʺz~L=pʷ"egs3b*ۏ*laÕelF 3dV)Z`Q~gD\ZV 9..#-ni.֛&5զ7&@uaj>Ƀ~sZP&=iwM|۷^k= |wn4eހĢ2Vc>hI̪+1{ huzC&UP~$5uܸ U/iv9!M ^).5řNlonE fD"TOr̟Pssȍ>~Qv^q\/Mo1@E`w%=&ɓ.iR=1ά'Z-LPA 6IojuA55_W[#K0-mw-e]KFLnB(c2zJ?̡.{QVT2ۧz@7EZ][&}o)GiWBx|aWnG}*&r.CL# ]|k.wetؚo} '5WC8)q8 ~;zȋVף3~ >E`˂З(]IߖϟPwLW>9dU,{\BR1!oP6+Þ*4nDV!Z*ư?Yw5{=n ,jP0zZltJݕsR7_)|'fK:yTggy>GG|ݓϋ 17?tOZ~NLt*wN1Qwq>}ƕO)quy}uuANck,(Nm5`,:XHassRO^@{~vRM0A;zשA~7zE:uLPuDg։8YA[/nMj%g*S5o\Ţ vyxk9o8-?Le@W Dd^n3%rv3d^ ''e,>" 4B'*A ybgTh6^^)mvv_k} a=- z 1lk_' Rщ>N 7}yo{M(2|Gzh>=kRVJGaʧNTӺeҷ@f|CQMEɔ/~ZNhhtb*A;%EWjEIZr7!ӿ< aׁrjj<srrV Cl|髋42{ .kO{'v2!No6E!W}jeEӰ1u,(p8cqw[Boa{ .`k)x=@7K]*x{SѻƯ(#]q.|k\,ei4M6}WiFGͧ|1Fw?@v \Uq_yݠ4_#I8y;sBп&搾 6Mz!~P~=koxs [k/Ktd3Xx7mxʃGUlUs3>vE*ҟrտ00i_g~ٸQx}!b|o`}ntB5& Į bfݽk{]Lsgk3DL;}SG[(82QI}TX^$FvqQ~Vq3Jڗv%ҥ|Ӿc)_i:=O=g:Oj+zo}o6\pC=$}U}XF^x,43D2_m%͔=Tj=׭s3sެQp-W2xV_"p_o;89fbb 2`7,9VԌ,9ݻ{tmt_\[K[1/ g):b+|M9 z+tu| S>#U~**yأWX*8q+' ՟Eu4F_Ee(ssp_|3;`q l]Ǘ& Sgr$KSRF붽cy`! }񣉷y_oO]IMb{57쬫.{=!t>:]G*Q Uz5zi"Z̿d9M|)muץ4;h~6JV8Nm~EOjD(Ai= }MBGn]W& %D[@""iPca2S G+n8q>ڷ]@}ww}/= Jf~ {|l_Kȸ> +U {}כz:MMֽ8#} gv5>ѼdEÒq Zv=|WWS>M4gA ҳH9*ɀK.j|wpggx,[-?gy<>PwC-^.N}˝VR*_~.P9~o/e\eu-/ PI*PʒVe+)wqJ䢿LI7( H9~ܰ 2PqQO mu7J*VghwOjۂyktRyzs4TIL-HU#xWx[F;a uS+kڹ9Ġåsq)88{?io*Q߈oDgK6ehŰJ|p}]RV}y3Тo*շXu%AF/[;Jc&m}Jd[}/Kf!e Fo:e |u\R]`bm45K?5;I/rk}-a3°ְ+dss7tw'Hn2oRU\;i=*G]Hz\4X[R.KS;x]û;Œ|p,%bD!Y-ih>RSu3טM-ޢ^in7d?!"W̞NuICs{: k̎Jܖ+|U-~P`Hh28vKhIL/"=V8Z1y[ne⼍q3z8#)w#e{I6d*ے~`Y3[b+j⵸}C\|eM{V}΄(XoI]q:nlա}o,q'Qo">gD'1~f2}K"3}í9 9_dN;Db.yH;3|St-Ruq>^ ~ ǘ@uqzsMɍ6k@2]y:]Tq}'f/3`ؚu> g ϙaoy̍qg-΃>شz=Թ:"UjwQy;s1ZSgt2ckO3m{Bު|SZefJ]_Nn`h:}PJ=#p@b+fZڝ/[/=oW//%RY isZy0Қ]oYQ)c+} e  /RY#S߬!iRcuw.r'TCHKB&$D!cU{s|e& 0:q_?{[]x}؃иCS44SIj)WS27ld4 )örwjrN *Mg&-oh"]"Kq|^^FjwRYRjiV+i;{Z5V({ޜDޕcCOaڧjH?&.^ْ;-[6bِbbE67qg7ig!$S{h5>e-J2ޑ=%qO$p }(e KKYXt!/ћE }O."nk=;*MA9 k!hnu}ow"K/M|: dдxqgI kYkK??n7wU'P#6Ñ..G%~"ߒ6D@?JhTOw?5SY+]?)`xWƉI+ p Xy^1i^c3ou^*#q}q]yqrPuH4жY#Ob'JY;PʲOl %Kďalc88_mlΜkU1_RJ"D h4)R(⼗3 i8i@ P 1Dmj)M?sJK+"_Q'>6WQI)9jRw^piԥ쥃 9vB"3R*cKpR\W_C.+O^j]K2Jcܧ+@8ȧ|>|{G^n,X>pTz xϟPW whfc[Jsd[moJ.;/5{;pg?ts.T-b/4x?BPzͻ<]p=IY1W/i 8)Lxґ9G)ğS!_)XWmPO*sf~2&WB}D5z8$<EUHkn(PCv+A0 N|W" )J 3J>MPP|OM AIlL +K{t eeXᴏHe ҷץyi) XgfE%+ԝIQE%pQc rL!N_$ F  ~ !0Fq0 4>e*@tA0 &PV!9X7?: :ϠjE+l*ȟ5xI{\(=uD)ZT~I~)a}ID'͠<4D& @`4) QL:=?Q>ZwYMo?ߵ}:E![R+JzT$st3l&Gyݣ{s> =l.41/E3h :® kQjٵq_bIZ`Wй*u.BG˗M#lu.6FBjL\.l.0S# K& endstream endobj 2929 0 obj <>/Resources<>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 2930 0 obj <>/Resources<>/ExtGState<>/Font<>/ProcSet[/PDF/Text/ImageC/ImageI]/Properties<>/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 2931 0 obj <>stream HWۊ$}gCuW&Y] 5۰YL®gIRHU}:oP(.'NAww _vy/&= a2"H5/?_.r˰S~*% 젵! af-C=q'}~NKActܛ Tڞz,4鳶b:7+ONU56͑іtmcP@Oltqe YE

f&C(]ʹA2usVM3 1 ʌ2tJt] ms7 ՂḮ<PqyZe}:o*S/zIRPW\+ V)vf(r{nj*)!gû2N&gH~c^ZU}d'oK[#Y#`^63eVZjҥ /$z.{^K%znSHbyC"OW[fCYvԠ7]O_;iInmJwYt,m﯈m Dg «[lZDݔcq7ZQ&kϳI֭[5<M7¾AēɽEKL%pp+I^Uu+:χXOy\"9~A6WR;Pt8a!q@c9Su05Z91Oo;|׬Ktq_ 71FS"I`'6ඹ]z%<km>XZ=oT0p:ȕ2>MZjƕךR|%Z .xZy YdznfP!nC |߳TrgSNH5/]0,rпx-yr9l!V2H7享o:;];+nzܼT6W|!/=֦ zc[R^U,&a^򮕺ݺWҶt{(B7_(^WjJ̒ޭwI%HgJvs&"y;EInMAe'H7<<|eXy߮ pQ"R^؜J&ti/U"IrDqMARGtLF1Ӈ}=3_="2'tm}fL1r UR6A*)uK-5Dq\cK>.JNkrZur ˵NΗ I)6%}>$3ΟW֐=2gDm+^N~=vƕ1QfBvνhzyn( 7]3luzR}LDye6`ǤSB8 ڡkܝ&-p8u.vP:heBkd]0Em`Z&,|jݍ߶_!+>tWmfXJa<(luDgSOt7Y'+OqA:ad3]kG2[ !.bZ ~JfRa9 tm#v uL?fKhOdg/CP_Ar[}W\1qck;!nfAtzOѧN^E[3* _5TFz3eTR v[^/@<#J :c# Ǝf4xl=SD$% 59.YوBna,;"AU|?NmK zD gߖ3.($r޻%kTڴ7O?&i}4-.~LՃY[&K7h7\`e[tf/O2~\7LXEuR(8) 4%M$_j?!3LN?&Zc&h dpa}am_Jj_;#pAg1gL>gCs+3iDxxֶC>"x(Cp6Ej&axh7g<@kLZC5q]iH/%Te|oR=O V؝oCCfjEƀ5 lpמ,iRSI93+ kuL~%կPn(JV%;;gKAfy sٱmMA{Mȹu @U޾S;~\q)LZC?hKg%>59BVecX,ק|OgNԤڴivf^xP9@Ԧ!6 Y s-\|_& 2|L g;c635[|ks8/! U<,.ͣ)gh-9bAyPՙS ; qt,kx_\ nM\TuiM*4_{"ovyҵ{ԪB{ ڴXr^23ǥβo3w3YGkkڙsl}+-߮w?}%<q+βk-eQ,"y}comju]uBVRNFٳZWN}س-?7d%'9V1gs9 Þo5^wj=hǮVX}tp RIAJIi!})lͥ~AںPݣr{5iֹi|}_ϣ-ֵ?08s ysݺ N_55N~NFZewumjz2et >kV#Cnrњf')Hs)2-ۈX~{: "F$*i9x>bfKDG gJ>8*zDlI"%j#/0 . Z_DJH-FȐ%f:=X׼z:"9FamK@Ao|nN/H/:Gz5u|u/ux]}r?/&| lef]%hA*#@8Oy'29gϘZAA˶S:0%O߳O䆎y?c;ENTvp;\3E`JikC?Lfif=<~=Z+7I| j'VB}0.s|*P7 KV^)YÚ`%TxE"<΋2:o4XR[\ohS=8Dk+QSe|.5kq&S\__~3 2;\7G5pc ws܍^y,6/f1sX|]DKhs3^ 8n =ՍΗ(&/E+M ݗqPкW˟,jl_ȸu?٩t.غ|jaR;.=bOz!=Y>Ȓs6@&;Dg*74lB0nj}?wrxu#dZ9"Uiw6˶}]O(WbGԏUXP;Y3-cFWug͟^WsD`x0kLR]iw-3kpp˖5!4gQVNwuC.=x>,y(3ԻR'S.=qG*Ѕwy>";5"TNˇne=?O6Z=7%O(Yox:gJ ȡJ*Ιȵ9):ufȿʚ,ĒǪqp.5㝯+ :)8 ,n^ ԿN<Uv2oZkBe2_\䚷 Z.D[OxY '6+ [q IԿ)%i80'ݵq1#5%_# q_Ond.i/uFN?!;GIe?3I&&ݣnm9߂Ԋf)y2U>LVCi%YF%Ƞ-jQ~KY};! gS0ܞ%YEE-u,>n~)fq;'y]=z4f 9B?"~ E~*ؤ/bH|$- {LW%ժoO׵ٙZ5Z+Ԥif1$=/AH|5lmBOam _mN! d1\YP&'WSvXum4Hs$5a9vIhD@mn4gvIWW(Y" Y[F Ss];Pq{q6ʣB_~o)X~j_ݹ<[pdĀ :qd83RF1j(w/54,O@:c=I'xq51[΢WW󇇱“=P/kdwrTOs5Dc*lL'8d6꙾[ϗހƴN,>ׄ,adɁ#9]f;/,JOl(v$ yҰuLF=;6xv9Ueqk/c5?\ɛUߒ67xI9 >m$QPmEx#zzg |{ZϿ{\^N:fi-.S3_螰ny~j#׏Snd^_/ӛ;<v5i`͂a-^6 4^m{=n(a!`ސ{Sv"eL<" ӵvVՃ/W?\~} t~p;A˺D]{!w8s˿]m?oܧ+:k\S]K,e]R`>o~'7k&T#8. \kl;h~qy^v^%7䕝=]ǽ>ޭ9Oɽ5^*o[)ON5"&8xD\:I_Xוiu'^Hd8`E𻗴K;Ē2wVjH?UD=8=p<1j8uKwM)H17rqe* 8mE/_,Wi^GOmR"'Р%}`\#iQr˺HKsYұzE]UDɭ2 Ȣ"wZ+WBcO %*t7n[tHXJ=#Y_JZVT*r3tmO $V`uWǢ3Xl%ŘsG?G.OˉZ<T~5Р@ᅡE/\3& w)o9;#IЕ M~qF *Y9`?QMBqW[Xr-_C 6H;,BOMer n- ,?0}}Kp{1J,/(2R&ب,&Cs\^#fo!:*feԊijQ!Ŏ-)85|_ d)HR[q M{j,^峂Yo\TPj$&KUp j WlRV oUKvK6*mCE(V_םoR@.c#^Nv[P RoQ^-i(X]'%5vRoBR=|=GqVFE$d]K\ fCXu<]첒JIMؒ.~1}3n7֬BQOY@F@W t]ckᚌ*UM1Q5I1׊x A= õzk1bȄ22+Ls0XV%S0pGVDnxkAVAosBfGᶙ$4\LDb&voTLm `V->S,ʐ:?kMquI>)\(>y&nk>0ntl;V5IzQ!}Å+yUnckRG^:ˢYЬQhDnqo=k:fmƉoIC6iݮj́TZ#ӝ_-Fpߧ$0I|{/,Jo tWXdfddD&8Fq%^Z#1zh+\fbWC"h*h;61(Ҽfb޷T1\bRbMfýg{O)9^iMi\%0jgvcB--vlF'6:\& m5MGLrP.ePd( YBP=gm0B2[CFGǜgQb(Ԙ P3Q:@,I뢉ppXM <^)!6a[(vZ$1 -e{OY?A4Rs]ELh(9@pZ[S+*ܔ e#5 QR ,/x%`\7 3,qET 3r[o4)BP 4SPVʈs-9-24kH`ςc|uJ$rm_( 2oj iI?,TJS7(,JCmp;|_QI@)HIWi†U`Aju†i[]tll<RM]Ӵ%HI㻓M-Dj\\uPj*WC%dsp4Ze<ۧ˴Şl]4}땥)8jv<]Ǒ'܁D FN ЫkK 3SU3$9w@'bİe6Py ˙u/^3Oj(E2Ys+ƔC h-ʤ3sGq ,zC{t0ʠ)Ǚ)RҒ$yA:)2jDgwQveJW:O/A߉,`"M5p~~!ԤF!7JN@->_fc93><.92NQ&ZI !jflbJp7ȠΠ.[O@o7EțNM:v=M-|e>&ßNZ.Cְfꮺ1zw4ed:?f9KJ\DQʟQ\:2=+yWHu/ep{u((Dz\*cLr)nC١ E2~[U"+&w ;Fj9pJ".=L L^N^c'q֧5Yn|@JY$iSlhNѥ4Ŝe1841ljk(]8l kQ )ą{d4i.u~> s7MV0IP$RBՄ'OUd~d*s&Ԯ9Po_tz.V Vھ@DփՆDmv}u DX䡟fydm o@Nd9 x4 ?^;0`U`Kd52fl\xJLpü*1g"Ɔ0\[p>KS !l̤-FmWfa'I̅ bײjLn *z?FUΧ|*Xd~<&G,3&uۧGstAi` M g]A(O4V4%dQp*(~? ;i~AV+>pbҿ-/9pp6 *e]rPd{zS(QʺkQY3n3Tٝd{26ضQ3GHm^@ y#* EwSo x ESWKdw1 ;.q?XmP3׼Gֻc*|A>>/s6~a}tD?w-kQsX|ϏA-p?\t<#Iq#u s2]{nhA/xnG3[Wq}?wT6ߟ?q CpAc=X!w O/avx3%_v:}thoC4J =ryf*'5nhfNa꟱ # m 0)|W='gjFdK'I|AГQ2BWLȢc <'& yoDeoeI~7,E) 6~N?9nX~,ϼ~/8-<@śolQ*>H֥ZRu6sthoߺ";"߿sKcummg82H![ _5ȡs='\",yG8#+H{2ϥQNr^С:"\$bBHh/2){^;8V{Ϗ_#TQZ`P^L߯c~[i~|ukO|Cev?VidWKC# 7:??coB67P 6X-(P^j^gH5F uVOEm\"tKÜ?ٯY"%^83E1 @,,[W3 {8'*ǖ ivɬ| Z0S-Ɩv6:+p} ^KT@ tPAPc(bR;u\n3PHq8XC<4`'pza@O4NXǩ \ gd[.<€}%[>W>nG$ m^JhNw!}.M  T-RVӧKIl|C ̢HUCvMW訰 ,Z^} ,)33Fro*CH](4MWT)fb,0of ĥձʙ .11'h c"wJYgxTrFSIr+<2v h7اbiMG{T$=4"?ZqH-.q Q xvDx ?Ey~{5LlxLE 5;Nkk #u´D,Yj⊷N~[l\8xYޙ֟Xi!dVS4lCN<g8wQݘW!lJCko%+1I;>WFA¸[w>KXou˱q6v{.;F FR #qI}R{4D$9{CS}\1#D걼=$/=[ci7r!jbFR␋dob?e3A̪G9Jg3m#/>vFB.IHByJ}O00Qb2!rsSĈٶ-`jqk,W+Cl"9H_Q)S|TI SvMFhlP Dm#626z&BhRY"RR'>1m|S 6 @c?@jvG{Ӕb/IL {i AL[:GxKrƞ"@odc 6PUKtI&h8Ab̶ 訩,6Fq K`v## }Qr]a!EpbKGP((#\X6b9,,u&$v;:/3([p)!eSs|B'P4 ^wX;4GOP.К=H6NCEmًZS0 ŠQU(KtnG[,/%yGǑ'@q. x&1\p[OcGґYbh]{|K2&JvKSQdS}̌ܦiaycB5v<46B" V!}ev$h>Gyu3 [ΙC&ym:)19fYXԀ|;Y|˟D24KI㻪UT-KpsyKQՠW>T)iS\2_%7I KGY' >o/&5yyRvܓ,,cq֯՘xYOVHOM=X}w膮k4bꚛm%fUeo(ԄmCjM Az}?{[kǻ|{i=誎,i_TIFkܗy_C0%(CS盋V+nʋV-ô}-U{Y}V2r~{LSNC=WO]<{JuF2C٭+ Kh&5ʺ,n+C;Mn Fp.2mya}GjM3;h])I)jTQ[]7GU^(vͺ޴f吂WRe SWU+[?|9K9.r_#?K78RYBXR _?_8?yG[C@*o)O\1_€ӧtaoozYOq(OY \oN9؀pյԉEOW#g`B]͢ϭmBo,m,K$c^NOJ]]VO[\ēvCxWӼPҞ#Wib} `[x!)"FnzXz4s& %p"`u\ XݿHKS,C˿W-24=b-XQDYY5VD-ق4[‘1lwnzY"`#0r!yoEDt+}C+]x UKI81Fvw!+\mKSqpi*|' Vnn&2oSرnckV1%d( MNGO[3d]zl *C~jʳ0jIC'ޚ>O"wul~С )T73)hҥ1ʀRՕT}>kBTտ!aޒ.y蠤tmq)&ǖfMݑYb1]ZN$g,sczėFd?JQK#i4rA\IkA/ZJo~ zY b.t|"fILUit2AV_j9䂲4xQb4󇇎!pqoۺK;$]nZ2"pMr6fl٣&Kiﭯbڅwhw +e^B.-겪I+wt3!Q*P:FjQÅsj/%s~'?5+N(aT/߽$h {kt-xdʣ 7Zc$n۶iRVc~Zy` 3eڙ(LRW 0^An}T/p > ]-3Ct"&"/zP 6r49ST2;ۃ S& ]TYdQ7TنbQ/#=-)x 4kwRQs9Ná6YO8c[0bzNv-3m7:/ cC˾̩w:dHѭ\{)$|àFI;qBF5񜰳_;pK,lk#GΞ0 VIjQɜ`፺ta`(9ʜFV)ՃUv-TgT1RGxy'J.92)nQtz̽]Q%'H`E pى.Ͷ1[;A}ZlYC *y/ZqhƲwy/]:T0"Oocni:Q4?Z ǫȪu n&`bL{ :ϲGh,Zg~ V(tp4ӣR~=EB 6#ɴç˙;E94V4<6$|B_bl!ֆDAqb }.0ieIK۽T!jfrm'#d`LyO{D!-z)Kve5d+Dj&9֬ EVec mHd6k$ӆq)+>1ȪB}BIdG0I̯̞?zX^{-GzO5/DѾ2&9?! hφgjcG섙D"V1zzs %guǂD4xJ> AeYrsr`X2f_,;j k ``~@vt^#NxFk}kJ6^9ze&.pX5ͥa*w;D(Ds0V?1~ޡu.6XX5 /ΛU[<U:I %BXUW+уK\:*i!_:9a.ZhԆ#uҵɖ4a iDh)jAOc t&EAX_44 bܰ/\aު`4>Ha:DF,e</l w|^6Ԍ|/5{v%Zhe#[=Z #Y5߯-NVxGvWʇͯ͢ێVVFO oj[h9VV6!XkdLN!{E}&gQ_WdɈކXc+\jpk[Apa0?1v08QBB ҹqIjZR[$c"&;Mjo2#>tqcE .gi1w41ڍnOSXjHI&bn3(8nz[EZ}l4L[^kH~^I5OD syGh;S|QYoɄ-щ8 *+Ӛ73C$ݲڋ9,?R=G!݆ខi!RC0|*!*.XJ^),9})H*r#20_~8$Ptxp0MqK'ʝ a{Zm@2h!RDk,~2 SFvW x$3Y6M@;A̓>mI>-ڦ*MoMz,B{Rx&+4 < lb-?jh&.})?5v_Au#\n!9mivt'QL*:8jC}MӇW?Ahbf-y,Ya7E[w(eD,M(~QAv"ƸgEIa2_ǚp)Fk/UcH*NLv+ 5;J|uPJ뭴?冀gvߑWaÉq_ܡйFP^jxF׫gu=Ko,gnax^ clQJ;Ѵ%E+M10Hɾt\S@!ca^ECo3#=3 *$gYٝQ8_r6 4aWd|D+3l]9AAEͩ6$qdڳEep¬DS@mo*9LJX];g(]Q r!e0@c B~G%1ݍG*9YW-e Dv"e6)&šwim|epf-h`aD)=589 %Y,Ƴ~_vbq-ɦg6eBI9J2C8`CxL#>(}g&G5 @T<Ùglqb\JahP\Tդ+']oݕS7dB:&Ieuh<_W]+_-.Qjk5::onew;{(szXɚCz^G oeg9Ϭ&Ύhby]uא4ݟ#@.t[XwWquP64GܡT>߸FWUUHnwT*y0X"Ty*SQrE3'#4AJgFh@Ki2|#&ڼM( Bh1%7eRxEkL7{*N|^OY&줬\hbBcq;Hf} *نm#M2I2ݬ^f_~zw^T~5|t)!qwW=zmV:o^_/-YzK޾~1_(o)ֳ_~:3[7RP/x޸i[J}Q_r;duMӼ.6;8j9"Oքz vLkTY2uP-kJz u\[[0}:h^x,[LT]wSs; sK Cwa3N/-Pu{R'٦\_|:֌U*y{-͇~Xغ@ÎC2ؗcӥM\w/9f_7j5(ͯ8 2,.a8K+P ]NFDm{+!C0sxW<XmaXj hC$y+ -_]jwO`ff䗱;mJjcWV9`;xiH9dR)'3㛌bsnL9TTDҟ|[ꮹ `9$W#ddڗn5#8'i En(ð(ԠՍ,TDc kYG|S 4t`VLl?;E461t;:y&4ٮGߞWSe}ڠ5QH=[N`…6 sX7fwacԓ%dv`FH['lSc%ܑnw,0qB]?\n+JQdEE3Q&sԤü1żM}*zI\&&?-\Jyc!gf U 麷wa&R.thxp"(-?#ć&!ؼ1-MBu]bZ _lvܻa棕`!w1zd3e}эuK"*]x/'5M}Hm2oL>7!d U n9yw}~P96J"D'M>d3vGv; i\3J Ц") ,˫S' vFG.(LfhYP bUFNI5TY`84J"͔&qJPdNIU51C3]SSkC>$Д>V ,oGO=wׇ:.2VK&;*CKJa*SՇHj<͠X7;B!NG /:%/i*g֬ei2aJ/G? *B w uSv:E97n赶js9= NG䢲Nr'M&-> Z->Fͺ-|wR6+|!)"1ͭ@f\ND/mz k Ig0LdV(ȱDJ܃ SA7礑6^0eM I;ۙLTR;C^7Qզ{g>9;bV`roc)YJӠ5#j^m;{WC; R(G Aqz#XB6}N2 }g)T2sZղd¶t:Qpj2u6:#&^WR+i"B caV؉k$bQr]]2;,xc2/DP}Gg} Q!8?|0. ZLr3E,В::" T+e߃.l,f_GJƈH-dRUdan,uz&7ɍɹG>5)wވBek9-i&j%1c*jzgD[p6Ւ{Ҵ+e!]fB1q5O3W;\]8gb)[HS0TOg2^8ɜtTQ5o;n0pVx{ 5 Zq}hې8:7U}?™wPYkw6!M3["^u;^xKn "-@󼰞XNCt:}KCaDL}J_nUjI,-[сoE> Cn)]/ݬ# oylGu[ivT>nG~A<'A/|:m4"jeË|Xsik F8vzYrʼnonWk Y-^mnQ ;+pV6ޭ jxҭl[1ԇi MRZ Mfdv ύخюjfOZ̑/F$ũQNF:%^@nwۻa.L/"_Qҡjg$,dE-(eO_?}΢-0f'jв8#ziȟP 4 ’JC>mm5FNG|m#ߣ-CK2[+XlSLĢ.EG]uz;bh$ZA8I7sX՚Kz{1}W~*<R&@WjNux^j!>/YU *+Õ'X'Vͅ]8ƻׯnY^:fszUiTV8TV }F_K'9jǩ.gT=LJ6?B*ѧOUztvc]hp^Л"@U`(UVSi:$#@G5cB DE8N5~y׵XGÿAʯGO6$%+R[~WJ8χaMClLLiYߎ <wCF;a鬾ꡠuC_c5/nd H),uzCd[~mԩDy}c~N콴#XH$l᏷(18cOxQH?D (s|v72^Do*ƌR"gGokeecAUח 2}/c@!i=J,uaBYB&YVaD-JFay5J4㙭+klLniԿ- 9s#MFdk!Bʌ*MiRط=z3ɪWdւ.xr{ f%6iIPN-ۧ8k8vё=Dvo'X&R%GK/_xoO2J _m\WOiŤӟ\pORSB$*&,үB֟#UabK#X3Ѿ<}VƧOzz~r ~~;\ng*Y7t)7>pрqpn'c{U땪y\JJȫyw]>ʌ^10)21u~$ e8ߖRZ#J|P='6-rL.5~[Jǯy'pd%,㠛y ,ٯrN ؠDdE0A!vvO ,,@HJY*DT x;%,7FZ'yl-W4ʩ- K 3ub+0&2øMx(VM=0>Y&rE<~fo+DndJ9ơiɔJ0XF@!lf8@N ^#vLX̮1ύn߷Qt=s$@ѓQnbNINUFg߿RRj[tc_éoթI0)IοͩJY%߸U]?ߪ2_wKt?VW([Ὶ[ WtnB_־9øbr~0sL~_ï5?ɯůwS([˯R6,BN:N3=Ͽ~?/e苑[kd 0/v*[p*PќEc݆EHGY2+™xY7}L]'V3 gC=5Ml?\Ä>IsnmlQ3Ku? fwUobG+Ș=e;P,K ';UFl2vWX+>2B]F|ա6SjOV'Ɇm@FZ~Cށ(ApoK7dd9ѭAMfkn&NQvVF^+7ͲkϛXpC%[6 0NtF+%&IbK Cha2T~}@l;-0VECXr?.أf?oa^2%9%6ٌ'ˡ2 (lBbd$ cU6.i;j$\{gqyH`bE[v.1CYz?z AF55nbro/5(ǫF2A,'ΕkvuֶZD5()έz*9aݯ .yA2u[J`(*[OИKiǩ:Pc{!N ~[젆QP"@:^(/F|5)P>!JJZݠ>("n<nwiܸE;+pn"[{t[r:ot.~& JQu-Vժ> [n,=L2ߝ2ax/K)~jlt^%!z|\ʴL haܲg=} ;z{NfD<+uHtL}xz+R @ot@y$["}*8:;cT70 y> i ᲤU@j|FҚ1UjT7(QR ͻ楊l=ݪs*&VHr\ߪ$fgp#i E/7a*=F\V y#5iRV~sY +mPu >aA9pA>HȪd )J J5p'˷ܬ4 ŕqruS2綾gY\0xWYl%[>мhx#櫗ܣ+G1hM,9^gY7жMFh:0>ZYNCHX`B"faDGP2ȗʠ*p>fEȚJż`.`FA2\τ2:.5f Osw5Cptq vX^qH\ˠR"(eOɧRlߤ2z=󈱫vF)=yeBb3-QhN:&EX^.M$Q%WKhF<5-xrJfZr%mOQ({a ~￰ELUԇl1aɈ#y#sUvc=g>\~8@ϊZIwVF64]ԍɘ꡷L`gL'Ʈv"?cR ,, k6!#~Y=24PXd)v.5_w$y+)}#B`_O t"8*CeF$A.By|j|ˎ]+3f[1o_nk)mQuP^I9UzO_NxnHҘjPp[ pth(n4d|lz9b"r7Be,]2S`5PV~'l6 =Iqv+򠟮害f귍VMgE#Bm,4nBlslI q1]R Pȑ8;bS%OJJ䟞%tJ~ZOzt0k:!NާS3)s5,{P@7`y`U#s7R f=9Ȅ\.xF"J$ $O}ιŝЎEϠAªv  Ti;:ΑxVaG|_u+Έ3TԂ QTNs mg`׳qQzfB(!?kDW o3{n=¬ER7ዶ}j %KX,&; XӝuEw~ 6KUW3~ʾڅ!`Wή(]}5cފk0tVrh8a-p}vO7VF~}1̾3){+Dg'PZP98&1#n DcL*^Fx K Y@adhkQ"G8޷$֍#^P_p4chCU+9"ÎW4PZ[xؼk.-oX&W 7e+5D1Y\~ /U&7ؔ12P#s/$7} ]< ܽfFok#1|r,}HlL*;V'M٧_O}v9+97EF !E0d=G\r:o\˜~zch76jnr۱D\wِyao׭=u[ KrUs#U7Q7ƽnԍ1gNcdxmV ==L2Ẇyy>͈*+"u]Yk-2pp4 /X #B*B5 H򀟣4J@këriPKCA'rf@, `UNprBo{ByĿ̘gJN Gs}Y l³E3l00vb9hI] EuI%M:?^-`U 5VbrBRQ lpj*cA$ UQXkl\=WXI{W\_WyT6>>ڂD.{~+c3& Pl6_/oɺI'0=ArFc06g2hΊ4{uRccb[,2Tj*Q.4~)}DX/ͦZy J~ t mn<e/X` 5Ő,^}?|1Ej(;GmU4i85f<y[LP k`t[ǐ3i[RWY\1VmEu0265jІ}Ƹ@K],t@7-2:['fcu;l3Rٮqh_=kr{>%2_|Pb(b@]]Х6 GQR&Vu&FZD*)[ +2Vj^#s6[%pշ ,a<,- ; UL&'QO{&$yD )bQtB'7/y{#!Oe>4BRIƋV8 =Sz[ 59H&Y6*951D-$ROA&F4yޢM'RƞI9RK5JDI|!dس3ٛSxfrϖa컟(8ӶtfM #?{`s͗F7(xGqҎXMgc Do~?GMBkOYazDr!))^s5F@H{Y!mu3jF=?|cpG)| gZ) ɸU-L"BM;Ei}䫷{Q[K$w Vw(-Ԟ5cBDHY YsufС-Ǘ~7z`(.-\+­ȀJUBW_׍6{m,ɻW#~)3]gWPyٞU*0'g8L^Ҏ!Z =XE(3K x#j ؿ!{{:L[` u>Ƭ1v_@׊}(=Nu ^<)*Rq XUb"tB3KDܨ2W w@(攎D}1NYؽHyI,h8Mу%])]\,PB}[k.RQd_<hh X@Y(F/Y`sv&/ߖ4BJkNYN@i8teT%;&z;ȺevF4 6R%ZsbCPˑACKH*?mozzfgemrQW+!_BOj{R-Nt`j1ZsE),_D*–(Iad`ZØh2luu#އlKjځRЅC`ݰI@{LvSJq ߇gHk7rk Nذ(ii2Y4~ 0xE)RA-GgPGIyP[ ?1]*h8nX1uX=k.7.DXn: 45Nqp f!IҚW&k3Y^\85K4UKI[4ak@%Pӡ &ȲL(yIB3XgكnBLZКq#~Z*/)]TZӹ} ;HgCUz7 &.{.>ؗ`\mػ'jۑ춁,l:1$ Ut$"etR좰F!A䃹1[Kюon4´mVEܪdWV)7ySOU()?)kUkW2`o0Pe1ܥH8,5^"j9ek(~k=VU"\UàR'PxF.dT<}o&--0o˗!=>n!cPgkg)&h*ӢL}M,Rf"}BE!b~9s |qe5U> (&S Qaqo6\sq^d,Z/$X_x* ?TkSBtÑн6t*X?H^OOQ!V\ S~SJum<`n좜_Ղw275Ԝ]gtڹm:K+*u|0`kbW -AH"~&A2R| +cSvXiai:́ț[WF{(6 I% **ޤ!1C o?k`}<箞r[4S67sՉg %,fK9:V1Cp!Glz{HHU?Ro:ִeKp+_OYO\X!nFegg.g;Ƒ~* cvv1JmYD}KEW;e'{4dŢ1-PcU.P媊NbX ۍmQl;ﳷqo7xgM>n:}"kg"=]9cDyvJnd/z!Sdtpq20*@|&8'fck.֫WLO5< N2V>.Sg!BUU._֞e|'u\E=!BL!?!  ]z':*W8/BqD]̍ ҩ9*,$i6ڹmzv󊢨UK0 }\]Uě 0Us[ ?(|2;W|*azc* Cf갱+n3bǻY7Fr{(."޶b]ATIR fo?k\? 86 kgTV#܊1N<\0Š/a![YK!l&<$PAF浶sVWmT. ,rGK<IX%Q`͂?o\" mf3~ B:sR VE$!1V(qP+YY ;|1U9JՔ<1phߪ%4F@SǗyK\rxPQ\3p*mّ L$Ғ( njhsx&$>B2)Ryfn̰Vi~CweV򁍼tl(5V݄WOBl0ޓyKǞ,FA.Jղ8\ ׍z. f_/?Ȩݦ  ׆[p >BXj Vet^u'ox鰺lA@ 地qȅwZ8n`N˖4.e(9d"}g^bCW΍"0xmwlz)R6.ziʫ%Te]G8AR\&2 p}?P acEťd,V2 f <:abR*+G, XÔ p""ܠH %Va.1D@uJW}zߍj0:ɻ>V a'zJ?+bu}iF_!(pOMą'o5}fY~(B"qFsٞT3|=[7҉? 5S֋&ֺNY,NLamq`XTdnC#[nvн*#=<\>-9roh;XXrq=/mhoo?|W ?!kᕀ?oaTB^xz Q{\4̚3B8`g£(F"2$wywK>~B8.LHEꑧar:>f0ֆ( I+dХ nZ#8öIG QYg=@8"5b'WY0?V3R {bUN%gQRc' :kzAkRA]L3Gz\zQB7,챍ގ%g+=DlǡREZ&dGeeww \bh04+̍#Y_&AnJU bv7SW^w`וb-%9vm4 MаIdR^DO!Ҙ@6 sbwA[i\2[Cs_-r@t?_Kz1؀@ĂAH"@H,uK ƧvqfvTC/bP(o{䓷l  UrX*.!]i#G F=(, $:ױd*uN ?ם50 4sbCnpMo];vLj2ƙ֖Z$o6KSA󆅎 PH&r/,E[5+.NX8|s 4m0zBE|]ˢ>'W^Z`qu5q~h FbkC,2ږ<~Wu1Εn;TGQ2ѝﯜSe/k\`8s@Lt>ߪ"&HK)0(Ej6oN)QOK\cQU\h F-ϝmk*| .HeaQ=(Eb &)i9dr:tcG^nd\H*&5B.Tf:lUbk7IF*X >BL4jdsnCfs/Ye&VqF_sC8YW,} s0;YV$C,!eqLROzo] 9ni&@>&FQM$݀aJn5'$TT)}N軽i)%"&l6:4-C2b(iPSRQÆK\{.( ;Hr%O+GgƵHFpLòʹo#5k}ZpfPmT|Lٚ~{W-M]bK$˿Coۿ/ќ-3!d ۥTL^jDC[7KzD7-Ųl:oslڭLVBJ+ت-n.WT-{flo F>Լ@Vn,v><-$_˛ϚX Ji0UW>pV(EY8ѫ';ФÆT۫D$x $I>cbqmp[*־ƌ aqlJ8WjB&n GD}}f$!Z*,iͦǹ"QG{%E8j!*@:3ij#BJfo55)P:پ&>\:gT6KVbiydIա,[ 98h`&8v$lApښ&Sߐu!߉% Òu$VqG:ʤigj%I SOS(z{n1#AX?< ]SƗ h.[حSrcPd\2LUѩ݌sD꩕ GޣPi@~m[%j-quֆjf+jJ ;b2B(1mY70'6!Tph:S%Y4Pl07.^~$)2J EȰKpBle]~i-kci ¢!/fn|&._}lceN/]/=)D&}癓AO1'iΫF=x Cdҡ+V|̳yTf/#v'?Au}zeߧ̽s(IWҜ9`95-֔oDGӟ^̴)xD/-Ȋg}Kvt־z|)NO==he#CyBx6>۞mfejfNK|? 0 endstream endobj 2932 0 obj <>stream AdobedC     '$''''$25552;;;;;;;;;;  !"A1#24CQaq $%&'()*356789:BDEFGHIJRSTUVWXYZbcdefghijrstuvwxyz?8nv]~)Rԥ͂I$w>;TKSM(bזd1\O&hx:O[n?I MuvY:RrRP\96tBQMWQf@R3]m٭P޾6$6 9|6$Z\"檮-W\GjC.J r:rxmqYY$Ԓ:, LT%=J[cauU}E2 5;)$N\Ye`p9pLI̖WlSZ,.c##a,%rV[R\f {W!)ʊH} BN3wbYX}inb&c:j[4H"+e[6}r*S [&S"dJәXGC6{__;L$E8 U)h(J,:';udFy Q{_gϊ)2 „BP'IZx-XWÛM>!w5[e)Ź%Lt;!Ř55Sa .YBSm@Ye vadYZ$ɐ̈*J! 3IV~ b8[3KT!hRIFGmD:[VF_k*y\GpFJ;jsYzVeTu;CByIs:ça[G)z r"iY!{0rttle,\Z_sǗ(gBx#J9 pL ̡&RIm,)MȞurt:Sr) +#F@ԩӺyM:;1>2fĖv uB BjY4ii#:6DiLIU|4HՓ e*m+-bstMŀh?B)<85Pf9[ROR n^yң%Ev D:`L+Hte*w +7BzdWZsK#wq)9mzao9^PA6H\v"s. m,dTҬr8lq ܼ@Qŭ nhM7I؁2&˒kصTZ9[,N`'e ¾/UYreN(sVsq8l⮽vіlfčV|u)r2IBңVY0,<[b]#fm#sϣiK&Y.ȲRVmAs|szp~#(s W`d'[Hg4:ܬ6\VbآDu4( kB􌹹u]PeS!PrˀFipIGgIS؛q*oGLe dnbѭIHRBNDǠ=T xҐrK )(>FR$φؚLqqbXʒ&A ܂n_ f𱴚[z\:EGebu V9˺lR2\u"KnՈK<3FdivqLw4S24ݩJu]jVGBR Xi'v]1.%&TV9!pP[ǔ H@IjcdLhe9%H:}5v!._Rg1WK EkQARJ 3!ZZJ]T,UFsBJt!Y֒zԏQT"]t;'qr[л-*^v2OjM!AT)/T<9rݭ q93a \XVV奶)6֜ԽkP==}n`a%b'+.$%9$<ڐw%EHˬ\z_H5Z*H.[x݇8MOk\\D 8Sq( xhPU3ĸCO8n=qQ"\%ki%ZB恞]laN؊n0EN-Kd8HN8jmbHewV;)p9x#ap%.jQTңkPq⤼㶯TРVܢ ,S*dC,f<Aˆ}'lWb "a&ձ94O$׺S)nonնşK[+q$j$V^>;v,!|l rؔ`<;"]>yxH!!7yZj=-MkEˋus=Cq5+%䰭YpWhrm٧q[I(ln*{)fA`eOuBdWVѐ9qO8qBXv%DXf64~'mw2%1Z`6p$VjX/sU#1V$Qʔn#c=@ьLB\9NrDd(WφX,N"nm}g'~<$fOH<2?[ljn#:-Fd̆y,%۔Zp.l t_^xH p<)f\lO X,Ȇ"ԼQA( sˈ**H՛K{aehjuId%!$m pmEur5SQܾռ .)9;B AL20kmktjARA"2N؎\W+oﺓo%RZڒ<ùm(/b]+fN-_nҊcgy) [_CVH+e+(RRt>W][~囵B3Pay@S'3⮸^7{Dc»y㾒AC'Q#%pFOnmhą=5)9) k3̝=gxR+1k)[~DFeOT 9uOJ@ҽ'.SVrwOC÷\ a㱯AU V!Ő܎O wIi9y툘z픧m}WѥifpՑں|eP9"7Vk!HS-~Y5=[^u(HYHQI֡XmbNAr7d&BA<)H hȭOmSèTFR])KRћj;WR9jxɯ!Z;.onIGSDۺ8$,F.86o)#Nd یEpԙ-+ O`5!BjV7-Y{0,%Z!R(#t[o4^ZC;d,Ä;a`6-n*KȀV|z;q4m2/!9ꄅHYu!EG(Ql NY׺[OUEq xF2 IiYV8í[ αup$uD[ē)nwVi¢YmѬ/X/ȣ5C-ץcRScCni62+LFO0) 4fr=jrS-j3}Ȳ-rͩM-A HȴˁfK|Ԓ &~S3YndFodT6ޖ{RÎ*1W,NRHa%ՠ7Z7.f5f.w r^iQ6/H%+s.LUl1eLR#ꅡpM bNA;i*il).h -N3[ t)ZsQ9CR)[rɶ+KyyI ~1BZm=<Y,ugE_&=ug)Ja-҆hRI Fʢ4ḓ7yZOPJ/kBk G[>ӖBn]ܨtx #Qu%IBVBI F0'ŌSjιmr^jJ!pG4 Ę79nm&vN7&J oiZK(la}鹱ZbN,88iX DNǁX+'uH*R""-%GJ:2;-ؕԙrDZqn^X@$-`srL~ڝۗ:;KS)LTw)PIFDp=qX,N5 krvЄy6=>͌;3=qKa0Yܴ |-#ƣ.$WӹsQױ6QeȈnd.9EscD6#7+r0p:C+P9t{'AbW7 U+*K{48K\ V1sf!CM'd,S7LU*RTy@0R['Q̜l.~ &,a'fRj*&.U} Lm#5LjeWRl8H7,sn [t+Ϸ˷𤄵5”Q'Rs;*Z:nXWF /L aIB. o44"{?V'.:;\7[=6KiRHeٖ+b60XхTq *- J.YJx'1LImDmuxYߥ-GQq˹XOĐ>fw'zbnCB !Z8Y endstream endobj 2933 0 obj <>stream AdobedC     '$''''$25552;;;;;;;;;;  !1"#A2Qa$Cq %&'()*3456789:BDEFGHIJRSTUVWXYZbcdefghijrstuvwxyz?8nv]~*G6;>;TKSM(ڱk2(1 \LҺ]DDU:ړA[.aQZڦ@e9K o &4k\&Xa,"ŤdUQ7ٌ%rėjI6EU\[ ão@; 2$`Y6W%7BN/K]n((`і܈Gy@0J gؑ2UP;guV'ǀ܄2d3"( #D$4pN;%IV~ b8[F3.i&wJvCij<.ke@Wyw ЅzRN<8h 5wTʨvk /L)vDN>a[G)z*I9K4<UrDN_o]b;;:>ū9\yytI '^}`Ve&X7BKb9ɹΜ*NJQ/*š @MH;R@ASRN 'gXz3 <#mb[DFQS4M2 64:SN-1,X]2 eU_e>ސJ=tҖwձ9u ]h+:/m}YHx%<2t[˥Sdxq䷯[aV=BD"#h}*4#(ÖEq3L9h`W Y

? =m2ᦨg7]q)I :@AUQy4*q$ru4I"T ^|9mVƘEQْZ&_1=cF\S=\3=`55~В315 +!tdSeDIUFձF Աp2v<=YVʸf.i[>` i]k˟mMC3} ܳjW~}3k'>Ӆh] %RfSO (8>(Թ.`\uN ZEyHiuWq]ıŕ΀ʉʺ!+u"~x+#bz:^l^m!jDiYX˅)QwlZS5iӧ:p+kn~c޷cF#iuo@dYehf.W祾hߋfXms\dSVf̈|d9r7 Z Ц$UǟmXM)ĠpIj.D{@mGPTkk7/ۚydظԢn_ z7qD*.dM771JX9]tDj"e{kEvkbtnk HW&k*<# F>oi6}UtiQ,,J8i8qU?l[0Mk"rT%yS5rZ8}VP%֨m[ҩϝ͏*<>*NS4;t4uF3}q2fĖv tBԑ5GCI B2uDiLIU|4ww%U#ndM^lavʫmbZ@DX&[J@%ӚaLJ=UA&o#U/t(/'H@ .uמ|6^`i3$GcH+m'Gi(!) )(eIOѣ1%iʇ):KdKd.+;=Xxd(z# _uAI2.$s9z4 *nLT A>$U$M9 YP(-QHmd"#fz~ǺKziHqW'X ew *6W,8g>`0:q~gI(o8겏Q>8Ha+Q3sZ8䈋g ͫX\zP!I!ސ 2Bϛxݳ&' 'J"4:8d ]bcHFHjs=iQ:Vcٶ;:Zmn U=Z&c56Ӷ=RKwqQ5y/ {)pcVv1%E&2C2GRt5N/[WViA)sò\N(*mPLU  lV([^ItNf̺nnd, *ݪ\G ZJkV; &$\mxOM fY%BA*&m4:U 櫯eز̆md@wЭ=~]uVrVK'~;08~aUˆԛvqen7ѥl. %՗ X*ܘY'um8/H"JPЫÎ{h v+{#rA#pK=Ҽ:!Ibʏ3 L݌quF_B2pnT ]Yg=`*p!-0,;!ӲiHޛjI]F]ʼr[^# rP9!a;)\utx˃U6tn6طBqpULu ]'iDW UY65B',"l:"˝SkxZSʕa1tbz:f2,O1}p9iF*m׸ Ag-\RblWMX ddaDpR0aqTim0;.īܕsdfvT4ٗQsSV" 4|ZUȗ61uj &.fHhQI3 EGLK}wj~Uk&*ۺS$(nD*eϰqX͂&*Ev.KЊ\y׵I u-i똏ĝXQ6sack%LNutݧ6#ĕG!o<.uLe麏e%QJ&|S{͘fԏ6ERn@Zˏ9.8UJ&hJy'Ysn,?l"Ah qX:H"IcCYxdȆ8!PQ7y]m,?jlשׂ\p[qaήac8PsQdyao0)۳K%h* Jg~6D i-J&y9utUI G7e5]iUف-ݠaiyD3֪upoVR{}M8hQ0bLIޠ8Nf k6$ q]:.:.#Ź)6Jb՟ v HጱLB9NrJ ZpO2MφX+[_Y,*:ėh@z2∽m.kk5"y1X-mzq#XGr>[S!%'VQ֝~=}OU /lېr$IV^&PVEDZ.a .11FM!ɴ@[)<׎hz={Μ*/uE2 Bs/ԁ6IGe54S*}vn;m5QS{$bƺqLbĎNFK[q7lFLS6 RpM3#g,$ZakjGCNrH[faEXmep<&$mզyQsRB"Uج-.`^I!a5D=ElQ @$A˭K < :5m#EilT[UШ]}El j,ʌك[D]Ie&rJZz٪5,ca_"T x2L[.e3WW>m e뺭a+\wHhJquB5UsvLcY جWPŁ\0워Z4lA<MH+m+|Qɹ8FC@ #[$Ȉ ,{gJn|VQ>) ZkӴ(5㶬I XW^\ָ%ƈRz6Rt+Y瘯 6ڬ,)|$%Gճ/m (j(J+.dڊV,@:ݒܙ MkFJn*mcaЅT0Q3vd4IFR!np\e #yw:c4|[_gx*L™#%.S.l81h]Ñp z, fD.\]MueSJ(꛶U5E\*f\[Ti:ci2wnQ.R*ލBY q%p(^+Vn=K(طT-S]aBRpyHq |g`t"Qx/>A٘J }5)dWm 6!>kėKJ9/g[iF.Y9c 5]Fe7y"ezal.jtAj𲓛tf*x64; ݴ˒jaL*hHh+_-A1jwn\KPB@pIQT4d<ⰻiXd6-;7#9jMsu݇ٱfbRG)m ;r!DElJS.ןdel_NF^Jq#= Mjkih%fGIx R&Nv<{=ˠ[؇宍 E61'Ɉmh^"w^;C=.ݤ~mP[9:&nu" MXbHj[hkI6覞 "&g::\ 6D]dt-o3Uucch"?nc< 3]8%}CLdwy(gLE.hrg7U9^ͩsڥҩgXuo R^$(!MCT9lkXcK A*t?N&qG<\6;*j]R[I^'&$9F%CL|c-}Y[ue$ca\(-((E `\R⩭>㸪; Am&"s( .RDϯeTַvQ-pM yi.N'A!FWQ"ENmI;e67,\% Z s5V^\ͺN>شFhD]ppmy)_j}YXXeD0۴/ Lt&LAEPQU$U`'8 I)$ʺ/f*Wbfn!YdB)qqŤ,:%jt}1:TNsώ|ɵV#QEA{+}M Uåi̚&Nzb=]Iz=(S@eizSq\wH"Hh[E d aZ`t1}˪2Tt*CDZvѭ^uפ-9s @tk$Jy:8bS->}6zHBLwjnRD6XTʋiԪΦc!Q3'o>9' _ bw0/:ïfx0˺2xJyosT,<c-bb>aE"8DD3^ls^;0;1t\1&d)ڻp g$DQ]̕dUE^;Sĸج3M[(vyJM"0N!QcƳ R͆?-M2 MfXV+08 <5)Ù6e>;=$V.&Gܻ;HUMsuAUw:sL 'Dy= .UrSM( .يZ ;se)9V;ZCim&G>Yۛy2c(*C:"GsH9}ݍ/p6Vpp:Kqu8* Y{LMF B1f;ci‘䖍wI@@>g]}<#C'm6oz'zF)dyQ]}mCl,yy>E8v[pxG!\Bv+1k}UU.[R^J r]뎲#46\7uu bډۣ(.Yߋ`8Js.dEX~tI n7rwuM4S&Yg endstream endobj 2934 0 obj <>stream Adobed     '$''''$25552;;;;;;;;;;   ####''',,,   ####''',,,   ####''',,, ""   yBQ !"#$%&'()*123456789:ACDEFGHIJRSTUVWXYZabcdefghijqrstuvwxyz  !1"#$%&'()*23456789:ABCDEFGHIJQRSTUVWXYZabcdefghijqrstuvwxyz?0J@ji}Tʑ!L_0ՕZ"I%zRJuUViG ʆrRSBxX*PMq~%LȪ2 h$d@XhĖ+tf%@uHд0 آRRC4%آwKJ":[-R[5l*JY!t얦NIUbx[BMY%J/G'FY/* YÖ3V:tlsr ,G$5EQJK.DץDqd)EQ,GDګL, ,Ja$%"'QTHA)͉Ɗ!B)J*ꐖhNRB D(R (xfFrE&{ThLL&T9ݍСpD%4V2BB P3v9R%"&2QATd,ׅVK6n0Zj3fP%(2hjBDqR+,GrL$Ѵ0UR@clqymꔡT!K$":]V PRa9EwP%Ra):$*f(rI]LIaSJ g$E(qjuJa mL!SC$(BN K%Ԇ)DJR͓""HiZ(B[fBxZ!! ֩J(08'9%A( eHDq&R_Ti^ `HJa,Ȅ4 ƉR ę&J(E*GYXUqZ,*T8<9JZYU RwB/R$RiEQ JPr+JjS dER,(ic@*(11Y4sf$tA) U&(5S@A Ҵ0$8)m4J UJf,.ХfZL"q}}%!)gT+i,hx$X:œ$:!(AЪ_5ukTG#L]u[*V*S8B4iji TLE"2dQ Ru*HF9ABY)g6-UUC4lEҭR*A,d D: 4iKe RN@BiLbhl.pҿq)K7 Bf bD6$f#JPMVJVCU)Ebi E")QA ƍ,Խ%ֹ$BPCn{R)*RTGd'C!PЇR ƈUH2QH[[j0eJRXE,~*-;[%+J'$کBd1NdBJJ%)G$RTj"o*RrKYgB9HQH̄X5$PiEɔ S(,M/9*6)lLm,hfP3& )e:`ҭ`(fIt9"+$Ӵ0H$1摡RZK&UT1El!&hP&;rC72[*z^G[bjf)Jf[(Y*Y,T t1 ,*fY23F: RDŽhAQEwBT)PEE"?6t &$"ܤPTRjTJ(%AH2 ,hPA2 ,ZؚR()Qdؐe 0*YPlZ)B&i%f.Bu%TRwfk]*H]RYR& a ZjU[+JYdT&$JƊ(1ȺE"dR,& ZӾ$W:(Dq,iPA:MTrdSI&EH- SLT2FPJQ%dL֙&'Y6$Y UE2U *2Pd$EA$LĂAv_Vuݶffɛ$+TRY:$וfhT/BSi \We+ldZ>JU K&id%Jݖ*YJhRL,ܣ441NM(Ɔ)۔ʁLR"A*d4"dQE*("҂(1A ܝR13QJLe:DRTZ1"QW%2)B)PR2Ҩ(Ҡ E4,lLllE)+be23#2((c~PAQA4X+^z)B ):UkUi !B-U*skvRZ[$*J99Nz\d* ՚f?FaK%X4dE4eN]ԉҥQ)QH($J)bh"w4ʙ^#JHR##AXڤh4 SN:E2d((ء0^ze"U"U"juc Q>,,Z!C&jT, d 8Iw`}%HpK BVI}"))S!@'Jbhih;ªSQtllm( TR("$lsfVRTj%"2DN tL)%A$$hUR)阑bL-iJ)aK:ISB,(64XA)H4VP,3L!1NFbBP!K'RJHVTuK'#^R idR&:$A騔LvJdXKH$XAPAQE2dEPhAQcEltR*DRu lH5"ƙ2-6&qS'E+!hEr,Th Li]ElmHE TLݠmCo P+Y!J3B Jō-C%+eMQ/cI)LQkcD$QAFЕQbNvVڙ#)2TT1EXhSh&EtXh ᨠv@2Դ0H$4)S)iD%Z/+EK4P)K6L 3}R:U![*Rɔ&8tH ]dHfA$uB⻪n+X,HdJB 傔!L&:tExYT꙾8YZ^4'A.22X hA"D * hhAT 5ճRJP mZ`iC6J B\s f4\ҕ*fIARZR })ښ!6EDQkA&&4k5(ԪeTE*Vׄ: Φeld11",lgXTj5:(#*Fċ3)nf+vRR!)$-С 'FWJ%% B_T^Y*F)NdEaȢx-YU&eT)HiV:j52N5hC*Vʜ,ΕJBv&d҉ Y1%F6,*!+4%Lꃊb T^)Bat3foTG/Y2L't $EjʐRP(EPRT&O"J:i:tYIMbE Z;)ӨHƢL*(#7d؃%)*)chh2ʪS)PTjT̔L)R&E4=le- ]Ծ1RB"քi2hꕂ[%RU%nfJg:ZQ đF3)JaUJtS1%DuBLTĆeHմ0H)Jjhd+D(rKBRzY!PuTLu'2 iXG]S&bN#)Zd#B)ZZ!B rI 8!{Y)}!JfH+ҋIy2,H45PE"-dTQjAXG5 ja,;"Ł)P̙B]nXzO7*a, դkIK*SR$!9%HAwEnWu"RԈ biuciA eUdݒ-*U cADF Me#4PciA`,BBɒիZRDuYUhJI drk[G)J18R("ӢdȦE4QEΪI"""Jʯ%cc;jdgNT/h*dWlRfDZK)"V4+ĤuPc8(R1R(L(4!rL/MlJBJ>d ХT%JNBhLh,,lVZ¨С'5TiPAB6(K=WUjELT'E2v&$&J,H&J,LmJfT(J [Ca JJ [XE]uPj_U(nZ(tQEȢ-h @ִfA5[HdL|}vL E *R*$HER#9$LLd!ȂP bhk4jXbBU/J[ENIJPrdҩ W5jThYJ2J#CR+DRɚ-%4PbEN3&A&4%UJU J$Yv$EFƊx",1"tZÖpfɔ%OB+B%fB\C'J)JI k!JNm(S"B)DV豦SQipNe*2(E:dQFdQEl%+!P,!5lwYS&JSmlY,IT(j(P)f颊,g$ƌEXA3BDeR &4NjTZj 2Aҭ5d%liJ! Pm2VV*a$ u14HG]BAPiELjީYTlM ƍ+qJ%DJd1FE6;T dLJ(ăRNrY[-TS T(ddiV~Zòh8RPB\n4.[eqQ y|[nⵢ.*e\Ai[ч"TfG)ңK@U1PMW4JJ.I: ֋R[5 Q B-6J_ViJUEPEHR6SIeԨ2QJ\eJ*vQcA$Ph%J*TkLԇQ֭/4!aHRIRhYZLpFj*RD%!*TS"Ѕ|2*Y v%N R dlH1wL"* BnuJDAS)E$ZXH4W+V䩔*$*dAUc8ʕF3)4+B("E(E1 Ehp%RULѠ2eݬJ WBh ҳRDTaNhH a&EyUrzJ UNdT$R\Xg82QA$9L aJT)!7:(ƙIyHV9@Ch"qEr y QLЃ\8"llsrID!ZZ:%HpH=T CQ5pJ/kQTfBmTH3ufR(Rj*JsJRc-J]f/I}Tj4K%(EU(B a/] %HX,bJ&)sK(JF,u8TTEћ PR*% ="H ؙg4OH22 %E2dȱ *(AQD !R'UHEY u@jTRUIPJϢ RfZ%EBFsum^E)JuIRY! E+P%*/Y3!+5!t$JJԑFRE_&R6BsQ"t4$L)S E1fJ'U*%J**QEJQ%J(1XE\2D豢,hҪQLЌ?0fwhRYuꕬ(.jQK3/X0Ś`Sj %$f=hkI(\W ׅB$fZ 1F* ЃmWDZ DT6SZA^JI)R%HԌh'L hE*:$mIQ<\@S2&hJ(Dؖ`کR :"LEvA2tPiHQ"ז-TJU'ŒZRB>ʭU)RRhJ(N׵ PL4^Vf9%AMڙO :BT)j iԪDR7LHU6}\U)u*PFsN20ERjl:RU;Ic4u@Q%NT6TM(117EfQ(TXr-R0%uQDQ8HLt3%0rJҁMLRi U:GEu)TnTȢT_\)YƐI /i@HD :t ҕ8z29'I0sC!,7J9AĂ(ȉ@c:jdIS&$J$gGXuʩ2*URK ]ҕJ)YWUq }TJIW6.5K52T 3f BɆ! JECQ+) D#-T'L:JS-:f6JY4c;ze"təI"d!e&LF(q)002.jPBREXSIЦ`4|X/}lةJBZRT)fU!,bZ)PHRC 2UJNA"AkG2yURVNQE2*6$iTaPc%mP&Uf$ccE锪Q(*DS(BtT")2 "AUUN Ne$cASdX%E&qְ1EBDu(}LKU0ن.EJ1TRq a(\ Z}f'R %ǕZET'E"!FnXWuTЩQL4 J*.;R$DHUupSU :)ӧlAAC@꫚LEY ZR:fZT2PUA[4~oqjJju(XFJK)/Xs^HfXT B!T;)KEjDʕJILu)L%):QDHXnUlH2 IJdT(%Pc2*U(29J*(ȐEk1kJ$TiRJTPJCA $C3tΫ%(PAJTɒ!,J+J)SkBJRQ@@fHdQEQE(XΣ"ƈA$yAci9D4 d 3҇TXr~X)sZ)y:chż1eBVYi "4Pk9"ДV\t'A)ZdIdUIA2T5)l 5JBY.kSY)Jj0B3JMɉ5ƒ:,(}Du 4&(K@TR(H"A[ QNPcE2( tH;*fqJϦARQhbp$ ^/2JZ-9>ʒZuU bժdٛ3(GX1ZyP6p%k@UVbT%( y+AT3H*UM&iPEdh ^( ('iA"ȠC(Jmi;c)UIXȡ7EYjJa"man0 YLTC4N BʨiS1HJJǐ BD maG*e RHċƋ,H2MTj6uT("Ԋf4iIZu)E* L)(ҁ*+EK%BT*R%*ĉpTȻt{UYLDPb; EA4X~L)B mP JV+PNftA|YncՊRNiB!uL ST[J mEaK%K7zZKd:9%JLsschh:SUjD?Je"TWk tӿis'1R3ʽ:ES()#T0&+ŪZhjK5kEIT5TM eyQ%Q$HJ Jd1!,1!9`bh @%!Ȁ֍+2 XAcc:tY PP4FFƠuSCҴ%א: (H&D JDE PE(hm,A endstream endobj 2935 0 obj <>stream Adobed     '$''''$25552;;;;;;;;;;   ####''',,,   ####''',,,   ####''',,, ""  !"q12Ar#QRab $%&'()*3456789:BCDEFGHIJSTUVWXYZcdefghijstuvwxyz!1AQaq"2R #$%&'()*3456789:BCDEFGHIJSTUVWXYZbcdefghijrstuvwxyz?PRU89 s41rD$d.|2AtI àB bIo[Db0䆅tR%F %FL!vf"aJWf"C TS³^sAJ9V XF"dl)D(xIVL2J"!AƄ%qF333ND2L0 RM(jX!Au CRBJH*qLEq0i"!|DAODT$,J $c"F9!j1eJ B%ͨ&Bf r`Ǔ%TI'IT: KQU; aE#yw F8.ydBpV!H.Cl3*± pxTF/TԜDs.$,8!8K*GRb7؋ 8/!%} Q\Whb!C1ʰ:Jݣ9h9Je@1ġK1MF ⬚U0`%&#̐ !Xɡ WAÀ4*Jt:dI%I$\ $I%I$\ $I%I$\ $I%I$@L),3#Y0I8W}@/{E9ɲCBNH)Q8tViN #B*l4RQKj)$K$I$888I$K$I$888I$K$I$888I$K$I$yHiH`D:ZI :đ Ĩq-mG0QTQᚾSd!G@Ca8{PЃYjTt:dI%I$\ $I%I$\ $I%I$\ $I%I$@ğ\8ÛHlX` Q 4$S ($XO\$+aЫJ4RQKII$I$Ipppp$I$I$Ipppp$I$I$Ipppp$I$I$Iզs@= i@2裚0d:keRE(!T[LE"Z=JGJ )(E%5I%I$\ $I%I$\ $I%I$\ $I%I$@&p%nT&R+de EIp;q Í;q ,h!ҭJ0IppppIE$Ipppp$I$I$Ipppp$I$I$Ipppp$I$I$Ipppp$I$xv)ъV QHr6fV!S<"A$L aACɇYFJ'L(ppppI2I$I$I.I$I$I.I$I$I.I$I$I " m"P܁@8%$(dw` aD񕸂k#BSadI%I$\ $I%I$\ $I%I$\ $I%I$@Ѣs@9-i@f$6 ( ΘP$ (ABRX;) (TE*(RI$I$Ipppp$I$I$Ipppp$I$I$Ipppp$I$I$IҖ8T!-P *dPrYd@ &R 8QHU! BtES[aI$I$I.I$I$I.I$I$I.I$I$I bLYHRmZT\j0_nV*B4æQ12KaibHX+[trƙr;$|51gG*E;pW@w4TEG[;|8Er#dQ`2+xɒҀPDQ%@EJiDI%ErM &^2cJTsvÅQg f#b=ϲR٨[)[*i endstream endobj 2936 0 obj <>stream Adobed     '$''''$25552;;;;;;;;;;   ####''',,,   ####''',,,   ####''',,, ""   !"q2A#1BQRabr $%&'()*3456789:CDEFGHIJSTUVWXYZcdefghijstuvwxyz!1AQaq"2R #$%&'()*3456789:BCDEFGHIJSTUVWXYZbcdefghijrstuvwxyz?$5̜s1'5BHYBΙ$NID؂ҭXH͍2ܢJɫB !*QD@$0Q*TAUIE<+65sRjOWdɌمUr NMdȬHVXˎu%[e1)2JVB1V&Ȥ&eU*˜"%6bϒ2kߑB4VRB\EN"duqpJ1aI*$: "Rв%JԗEqZr|!ZphK.T @*JDJtNcV5*,6\h DyzE0hh J8X.yd)')thf5XYhLdѱ+6Wb Eh8B"%I4@VCE%Ԇ]&FS) Lpܨq)B %qR\.BO(O{FxIM f %[%96N*qR^=Jxg8]B@m!uUW!P1ʰZrhXD&جI*-b*p * XR]jl)#T68؍;K.(C|NH蘍x"Ĝ@q䤴3.Wvкȇ! *e%$'kU'kUQq>ʚERI csE-bF|m0Q fMYbGS(CWf"dM$& tfU!Du$$K$I$I$K$I$I$K$I$I$K$$@l jl"40^0,sd"̓R @I`b .6Ve*2*l4RQKj)$K$I$I$K$I$I$K$I$I$K$$@׊Y IEr•ʃ@Ga ThËҋt60Q^0G,;lVJؤۂJl6 Fe(h0N$Iqqqq$I$I$Iqqqq$I$I$Iqqqq$I$I$Iqqqq$$HĚtmRst8h(X` P  ɉT%bd]$2<˄*5љWNu8h $I....$I$I$I....$I$I$I....$I$I$I....$dIէsBef_sX d&Xv%& aLU*k(TG(RI$I$Iqqqq$I$I$Iqqqq$I$I$Iqqqq$I$I2I$֘BRf0R Q̜d  )$fʉB-3cn GF@hs`4R\\\\SQI$\\\\I$I%ĒI$\\\\I$I%ĒI$\\\\I$I%ĒI$\\\\I$$68jE!Ғ@A2 nS8Jg؂Rl6 uљTjTt:dI%ĒI$\\\\I$I%ĒI$\\\\I$I%ĒI$\\\\I$I%ĒLI 6TY E &Jq7b I24pHVLQ:4R\\\\RLI$I$K$I$I$K$I$I$K$I$II$ѣhChd^ci:g. ΘQ'X2PEenX7(U!k: )(E%5I%ĒI$\\\\I$I%ĒI$\\\\I$I%ĒI$\\\\I$I%ĒLI & AΘPrXdaD,K rUXmWZX9A`h]a⚊I$I$I....$I$I$I....$I$I$I....$I$I&I$c bU%1kc0*Q qE8&csE0B()HEnhV:RNCDH\JfkbzꐉYnr6$ۦ12ky$Zu-ؕiH)!ŶI^&12f JDؽtvf)}u%f񲏆R~w8=ivB|jp\%k A+#-cvf K},]ZPۧ Pl_ňlqJC/ #6n1'֯r`İ|(vx^pf|݋A49Pb} $@"2nRN ٦`)̒9b42 8"+& xLI+wƾ=u_mqcnuԨlchۨ10ē HԪjJ6tUQ8V)@PfRQ2+$';b ʃ]1TRJ0IqqqqI2I$I$I....$I$I$I....$I$I$I....$I$I&I$ endstream endobj 2937 0 obj <>stream H1 Om / 0d6 endstream endobj 2938 0 obj <>stream Adobed     '$''''$25552;;;;;;;;;;   ####''',,,   ####''',,,   ####''',,, ""   !"q12A#BQRabr $%&'()*3456789:CDEFGHIJSTUVWXYZcdefghijstuvwxyz'i!1AQa"2q #$%&'()*3456789:BCDEFGHRIJSTUVWXYZbcdefghijrstuvwxyz?ٔTqfg+ASL j ez>tΙ vL!x*Մ ddFnC@r2DD("C+ʬUpFb*D0LQRfƭ#Rz2ê^LfT!ʘLJuc EbU@ ^.XIVަ%3t*hM.UWq̪*aB`STՙ`Jϙ) &(SJ^+.UT*&iKJJ#ZW.^I8YSAYCRnVNj+] hU.SpSP+*H@3lEmY Qf4ʉG!5A,A+(NoN'%ɺ432gv h5*i猎"4TB &0b']HfLLniˁ Lnب8 0jJ)pV4Ls qJ;; p+]L&ٖLLfͳ97u Wc! , ǽ8 q IiǏ ssP&7P.+Cc{`%$ 0&id``]&Hn8n \@`+Iu<5RiCb4U\:G {)/,H@p/%%4GZHvBnWUX'SI[vB哵E^jkEщ#X]LE.r)1UT&(sVXD(CL 4"\I^T*TN$I....$I$I$I....$I$I$I....$I$I$I....$bHP9 Ek6dJƄ$T"RbMbH fm6T ny*"V¤ ⚊I$I$I....$I$I$I....$I$I$I....$I$I&)E׊Y &E5! &XFE i@YaR2.G0}"t\F^j2Ź٧nA)hJ4N닋II$I$Iqqqq$I$I$Iqqqq$I$I$Iqqqq$I$I1HR(ĕ*l&d9>Q@$`du5#\J7 #n]]z4 t*p:R\\\\RLI$I$K$I$I$K$I$I$K$I$IE"@էh2R ]kBILaDI4nU[*E\z*#ώ]ntѩ....)I....$I$I$I....$I$I$I....$I$I$I....$bHP(M':id"/ɠ@ $a#,MT`HZ70B3Ы`hhqqqqME$Iqqqq$I$I$Iqqqq$I$I$Iqqqq$I$I$Iqqqq$E"׃6(jE!Ip؀:R ̬CNt|SH%&r Kɇ=QRCD닋II$I$Iqqqq$I$I$Iqqqq$I$I$Iqqqq$I$I1HR(T5K!McQ, 0LLJ4΋r I`1g@jTt:dI%ĒI$\\\\I$I%ĒI$\\\\I$I%ĒI$\\\\I$I%ĒLR)ѡh2R yŎ4(KoM[VV%pUy<TE )(褸I$I$K$I$I$K$I$I$K$I$IE"@& A0t%d$a#,nqh&usώ[sR\\\\SQI$\\\\I$I%ĒI$\\\\I$I%ĒI$\\\\I$I%ĒI$\\\\I$"Hc M1kɀ-SK.A7+(@H)Bi(.E4΋r U' W ކ5*P'tue gIr_ S66-Ԧ0, O j&66YL0+.xe\Qz/ܽtJO , 71;$ sZRDˈJxVЄ 1aiChx/]8]r8n]e iQ^6357:&w0dK#TW>@y5Ybl`V^JZQWn]-0SCwO]fi5q^v34&,WUƙ) H4PW; ƫYz0I; [ÇW>Tn^I*OD`e6)p'Il@S29E"R*SEadL鯙I& ذk͝z6w몶:5ԮXֻR{uCRxpM@ƑH"Ԫk"IN5I$գ(V)@AID)*3^'A%:kH$. h1TTt:dI%ĒI$\\\\I$I%ĒI$\\\\I$I%ĒI$\\\\I$I%ĒLR) endstream endobj 2939 0 obj <>stream H  Om7cl endstream endobj 2940 0 obj <>stream Adobed     '$''''$25552;;;;;;;;;;   ####''',,,   ####''',,,   ####''',,, 5""   !1A"2Qa3Rq #$%&'()*456789:BCDEFGHIJSTUVWXYZbcdefghijrstuvwxyz:S!1A"2Qaq#BR $%&'()*3456789:CDEFGHIJSTUVWXYZbcdefghijrstuvwxyz?i)RRgRDqc7MZDuAei#aT ^\^c+f\!VԕE,ƕ A X\` MŁ1$N( sa02R>}t;ebp!I JQTKJ:PmPTVݴRq5%/4>Gb2ehHJ 4JD:Q$0A%/BEkuB]( M`=ҳ8I X1%TigIIuؑ&! =%)$ I)/Vu 2Ѵ#i PI2e-.#1FQpz䇙.p0j%J7i pFY3YS2X5f3P̡)WAh,A" +Ԥޚi $X Js \!r6+$0ψe?WBc9)zH цF /j g,#hO$$eJlJߚ Ե2fYt:GxAa%34Z$5Z 꺜ep3Z28%HhR'()Mx6EQb3KfRU@N$QLۨ=XH/([`ri [NDIkMlL$ZDBI`JVcq(>*i[MɄ5|3"Ki {ViXSȩɨ&eS&k Iga2jZέH*JR8h=ѥ6b6fȀ)@!zM!a"*xC,iBŚ^'i8$rK;1BXRE߹4K>j&4Ny S|J 3с2:TҡA>!HqRKHVqUP R2fH\.B7drghP"hEL(!LNd!6H&N/*MT:ͥ^m*)0Y/X(E "S|3-,B:dsa E Y)eHdV57?90S -ISYQQXIe00rT-yKN~j4Ar8X Ah<ѧތK *a J$:RVR & \ڧ!Uo1M[Ab0({ h9Y_SnhY+nЩ%H+SĠ:W%( H YDamLY SQf-GkuH !* 4A|W2qli$g =C-P2*j)FvnH uM6b\Ur!#UAgf%)43M-!Z%^e2jrjBATVj\TJAV _cB)jX>ˠ!t"P*+% X3gD&t:^+h64h}.zY\$sSmfĒI1dTh YM9ELu)AI*%*iB %@Ll\<J i2TTpIMP EZa$ )f Tk!E@ vlȢF)sBnaJP6q iN6m 5)2\kX@#gRAz˃$|q3)qր)L"\$@F名4*+ypfY9%;$2'TR̈́d&. 0Kp76X+ĤćsTZ:GPZ5a$ .q0DGMЀ&9SkZ/rYG 4yVJҷa8X-[ŔV眉*3֬W"ciT5W \"4jV+xPLQ KRU(ItQ%.ElSm&j5ˣif+S/kdWƇa2T*4s|C'f쒹MRL%(qq5~af3wU[s2:DC˔3hBk% ]%؝%y)/K>zʽz%IAUeRJҠqERGm{ǝLT$2 T骅UjSR9⊋e&"̫b9! M%SN3N^qޅ2)33MKrA$ `VǯO&ʪ Z\/mR59+lH ?=*!J(!9Pfah-ys$Kj8UE'04M(11OsP7,$ E W|gfUGIXJ dùȚ6Q6υEJ YH.`H7qe^4/xi6L1&qI6Vc|&P)9iŒ2%!Kx\gR_)/1$jAs5SrKFQ3 HsjJ@"j4M>l&jtXquTҞoJpЩ3Lbp*71%^nӽ0y{zoϡ endstream endobj 2941 0 obj [/Indexed/DeviceCMYK 0 2942 0 R] endobj 2942 0 obj <>stream endstream endobj 2943 0 obj [/Separation/Black/DeviceCMYK 2944 0 R] endobj 2944 0 obj <>stream Hˮl۶ɶm۶m۶];1 nCІ1 o1l0m&_3Ll0LmӚf0l0m[,n KZҖ,o+ZVլn kZֱo6ln [ֶlo;vn{:qG:юq':NqӜ g:q.q\ Wծq\7nqwqz< OzӞ</z^׼ oz>| _׾|?~ endstream endobj 2945 0 obj <> endobj 2946 0 obj <>stream 2024-01-12T14:09:48+05:00 Adobe InDesign CS6 (Windows) 2024-01-12T14:09:48+05:00 Acrobat Distiller 10.1.16 (Windows) AKR_Adv_01_2024.indd densen endstream endobj 2947 0 obj <> endobj 2948 0 obj <> endobj 2949 0 obj <>stream H\n@y01$xџFKRo=3[1{f2~77;ԩ7p-#{Xu};7~f B|_'iV+d#͂vd{sVOamBfR*KznƗB*st?}$3ulZ9SU]e@jk'lQ: sgۥ1n~cڛnxy0c0rY7͸ endstream endobj 2950 0 obj <>stream HUkPf^-qFYf* Qk-Х(KDD#y #&0Ȁa +Ab|%:5A=^La/ϩ[u~EА0dR\!KR1%#T\L5#FOrohZͭx❀c݊˯:#bN.k)TYi|}\ >lo ;TJ"A#N+$)i9JB,V*%EXvH쟠("䒜pϝM=H4"N8#|"^2d7#HqE>A فB"AH D!>d'?GYy.{yCc"t}'jF9gsܛܗ>nslVZ?z KָdY\ ? tM.܀ T7Va?/l[xV<5'qd`[&V/ ˉ3"~b?̡ jD1q]k)W'HbFō(r^5ٷDP$Yms.5^ ~NZ%z@Ooii2[|#uNJw_0K0 K$ rEyk{w6m|tc{a@gS鑦ZƼ\ʽO»2A6 d5.AX=p[& jwiMT>k2'l-YD ]=ԠwX-tH ֲZ?6NÌsf%UVJ;;*t: hVC W*0ay9wbhq12BL ^QmjLMdckDΩS *(|cwnQTdZin* 3::VRzsWm]9|6Q=4DzTdm ujSڙjS]}Vz_NT%Ëhi2,ytsaRCCWf} gNVU*im4G{) ͗#4i9-m({׋%`ik_3.R{ÆcK矂J :lFGa(,LTĬR'$`ӾCTՉQj=o3FRLDu~M hxp DWMJ#tI PHXySty}o'WdL͗vv!s,,;pË|=VєYII 9/}yjQl "wũRSʐ`"iwo;A T7u準v m],Ssa( 8_ڑ&mӵ[rtmjԵnnܤI4KeH6+NùC dW[LJiNjUW,ˣ< cO<+[}[ش=Wt-"y{\10sȝV"*P%pR?t'}ܔY&Q;@͖('0q% GBB4%F\۞gGJG=&&=C9gQo]` ̪] vӕZKM#Y,P %]*@i^V('wAA!f  H dpߓC+'oV{Icl FF0SW,pZ=p~YG'T%,ǀI,9 6ղed0{D-lzs9G?6OUQ E9&~H&4t1Si`& .Ts0E@ۯLmZM[ QҐD]6ݿU!EKuo4Aܠn Zsi;=+?P $Ɵ r@)7vSvVߎP%SuW65pk#Vju~vf/8:s: "_&\Q8v|geyje;w?t;Ҭ!,cAh3П7:n{+9eDDzO<BK¤DVhqa#moweW}BOY}|ֿ._){s`Fי-Vkt1GbQQ%}}RoϖӾ}X`6 endstream endobj 2951 0 obj <> endobj 2952 0 obj <> endobj 2953 0 obj <>stream H\ˎ0E|݋`KQ$%e1Mf>A"dߺL4r8wǾU}Sե)܇u׮Otڮ1I>۱ j}ŷ9&鷩 S_˯U8 *Sj%&R_[PL{;y7?ψ1\k4Cc݄!YeVCз=JN;_u βZG΅.<0& .-bw#`Oރ7 xK<;a#k9.>`]sS_k˺9|4 Ԩo^+;e<#`Ϝrzq s\>+֒fChYK OZ-Xײ5Zh)X˲9-{%^h8[BȅYK)셖/Q[4{]d%gpp7;owG=tYBn9KC#>${e?ks7뗳}?z/}7?Ρ-;)]MQ7Cx)E$w8*7+\r!< endstream endobj 2954 0 obj <>stream HlTiPTW^z v;.`CChLȈ  &P1:0 DQ 6a@h""3*"18!}Ūy8yTMeޏS}߽LaSq8#-@t|Fba砒y ,3!iJ 2XKa l` p@ \5*hqM8!.PXԷR;ˀx;ܜGoHrN`m&پy^LiȶܪF*寄+gz_&B^d_hexgNYWU qk(M$o(//&˦1,BRt^$Fo&޺i%Ƚ}>{C" 7t.ln`h*[ۡnOkb%!BsJ׀b[#'J"T8,LCl#-(2z5^Tk/:=7˃qKM&Փ~uB-o4Vף*ǎ>}PA 60 PqFXE# nc4k6lWPp/(,c{t? ֥ĵ{I';kh#Gj8 1l(8|8JgIes2Cf/AsRֻPy yfs 2 >9K.bd`懰W)"pْܚFhuFiXeDs;&l~?L%kG]QSZPCmёIE|K(԰2͡"6_o\\ =#phq@;_΍|7',9B{;8 >d"aj\pu<>:tRPJOaaI(\ y,i8E v㩑nI[bmvA&5Q[U] uC;bKFZN_#S_=/E^R mE YĞ\R",M aFfT]TT-('2SDsL! NUvr_$^H*  (@Lpp r#1U47+c8x`f6˙fTVE0Z P,mDE(EYXsqA>E|/_eED-h05պ渍Gו^ yܽ`rsl&><\tR'pYa5U[ J<AlMr&q al_3Gɾ-Ϡ hgzOttpH#|Z#W9leUa|39+4m{  5@@# 'hEN O!{6K:Uq߇|P,^ pvqѧxn0X/0FOe?Zx˞YohH m/'BP x+ {ź{Q/9B~(1[A $O h+>F~k`:^W f1>tL<(*#NӤqtg+%n%W}X(<%{:p,l!tA+NZBdSoaJڡ.F^?ca?[X/obe# [FlH4:ilz.L8!|`t]-fO낖z Zr1a|ҢysB1vlWKnYkg;}o O$'%Z4WWzD)Kc9e{OEMW˶,Xͩ!Ĵo*![-鞄EVX4 hVH$*hh.xŒ߈ozw@.xUxJfȀ't1 TU#MkbF:Z\MKW-չ37gu1qqNbLc76n;/]3Dm!<Ȅ>f*IAy@^7&&I7a?ڈb{HȾ|X$3nއ ΍LRe&cŸ& ;;Y{Dmr_WWw:Ӝ{9}0T"UJ__+K5ILBz\.[\‘5rL{1xlz,VkB])jğn>1d$piUIeb)-T_hgzT\ӑH]"yM(^Uɗ8s2I P  x>hy@^L486'RĕĞK5_IiDTd3ʳL]+ձ= 9 ̛Bq- 3nI[3;so?dq,I/ mFgDz֮rc Fnܩ#3tÖ́\4X2ur%(C-Ɵ_+pW S"Wޮ.cJsex^1û&`}l }o 7}_[~fW^ s˿){!|u3~XN^?Mns%n\oqF䇽(@B endstream endobj 2955 0 obj [2957 0 R] endobj 2956 0 obj <>stream H\j0{b%FKvC?h2@!ƃolFЀ^7hͲE62N"8jD JK+YCSc9P\P#oNfW?8@Q!|襳݄cԨP~;_fhAYb;3#< NШuA~w.g=IҤ(.$Az&Q.x #)#U'RM:G稲"QUGgD57$Wrĭ B_' endstream endobj 2957 0 obj <> endobj 2958 0 obj <> endobj 2959 0 obj <> endobj 2960 0 obj <>stream Hj` P`\`_@6V? endstream endobj 2961 0 obj <>stream HlV}T\6..kWw4oUbQDPl%J4FAI4QIM1 61kcOiZHMl4Gݥw5#;g߽ｙ޽;@@끁gCq:A yBe^@4n†E ,=_i|y%5otb}@:ӼJh@l$Ϯّ(e-Fuꚤ&d:͋틲 ,rJ1Bbi@eTZ'p؍?X6cؒjV΢~-K|,^k;g|OpzM ʛS^yYs{%Z(w7[+欋]CHS*FJӴلdv:]>It_If.ӹ@Պ:]q2b :3I$XH6 &HK%6OUC]U!&h+WnU0v9^Bwda+gq}q¡wƺ؀gdO.1)('| JŊZ;Y,-B* B+"Ej]r:ʮ$[ ߗ[f'OCiy[:X4h3c@%qa߂'W87X Gr6k޲܎5yiݲjD޽O65͘KυdeϦ3k]쮥m/t~+㽽*nD\̒%/=2w%" 2TT2PSv*=elL&8'=!G(Q+.6gIPJnf.͍ω!%!B6QbQi z7(w4"a»,a}Hd21[U04%Nٿ^?Yzs_SڽM[ƶhus7mqOٴ|v.9Rw>~H~kixeźnV׼p'ja^-F2*%|O[M3QW;@RQqXuVJngh55uƙɒu}L!0ғȾP>{!KZayL DܤX@4@ ƀ{. ?J1,"!GP QKm3NҘ-[LwprӯԖ5 XPD&_3/7~@Zi&*k ^`⺰%~LhNY^ &%.=2S7 Y6fDHaHPQ9$ 2 hoK` %N F C Znmn-LFRr7ݚ)تL6C3dBpBؿI84{e:4\Qo5z Vh8FZe$=2H gmQ2xE\؈F#r%B۔$R$5 "M& ETc-;[ Z%ӯLQ}Uz,vC}Q)K l^e&/69{nv]wr늽NюXZ'oܟ@LةR66M\C:TIo-a鬋f'&5?IL#t%䰬To=O)ÈBdߔD/Wd@-wǵ!CYbNc,8MΓ̞9;}++_:{f|?]H6+WOmPZ~K>"넍Rq_abv@UF;vn;!bPV?PQЀfE4h+M&4 m4( TG[34uV;0:mM{wIn>vyqJԩuOV\*d9Ks$ `ffU\Uqu\38-π](Ìm(~ C&og|2vL=%M+V'0i5@ XJr^GWv ﭟ/˞9qŅm`Q,'3Ɓ2pѬ_106?WWKLz" n,W;Pcէ~1`/w)r(K0sI'P{\槗i]FcY؅m4g06hwEuY(@ ?,\ҾJoi|#iZ ;_ڨzfq툩V]%Rsu,eLnHф@ 8Ze9bcdXDf(ȪN~,b N1$َϥd` j!E!@N)!sJdmQd r&Fz`qQqc׎3e{Wi\aNO;G`gcCLy$ Z9cF0  ҀxD1bM> NSze^=%.յC2$\y/ԢWXy^Ufyc*&/_}̾T%af+  }`8ah'?BzvOGں;/i^i`hm>ջ7R~' 'D̦>N#/ĬʌmP~KI0}a]4ӛSWyZv;k&On?ce͟b\$2Q߇}Tߧ#5J,)3rT\Ital(ݑe@s$$81v;aYcL&D$26_Q ?Oyg]Ea+Xr%7OF58"**pMVTǏs?23t]/oe+j\?mf+DZ 䯠'NСGa1)h*xgq&)YYf,V'*WMX7Z@g-~53XAuaS }Hwz8+!7:L݋7]-˞2ix70u37=vskӸ6-~KӴo`~z{]\sf"C)"O$u(yVC8`TPl{ !RjPeQjB"r-Ū*C4{ݩ Cƹt qR!E顨XcÊ_ ?[}58ziUﺘ]m:zakH_0wBEK>[u]:FO: U.[kK&dIa:F+x ┝iSܒORLT33jLH dRHsoQTc̏ +R+Az;}A=`TQ7'^i@` (=x=ۊ__ve݇nԴ"ypS OŬ:6kz~iIIxܜ_Lw]:@F4&frqTP*b1d+FɧOM@xoY%[= 8YJQ{!CERD -ec8 \o~Pb/hvW~}'& _y9݊M0q0z=Wڡ~ttdeKQؙHX ވ^f9k#.;c;CTz[5sՄaN1TՍ6(,КxE8b{Dx8m.?^*Ms=>Xď|d.i?zrËӞI(n׎ '<:=mujwl3WM,^TSS6R}ϟc{p0WL7c T(V)D#'cYT{;.s,YNʻ #VAbCFzs.'Jv6 |2q5Xb}U>77LJ3o826 H1B5~eJp>'Z1v^\\I+,º!5`\n5c E7 MNi<++-YLv׽7lv=s4 #v!66 `9'r<.{Ld3o,&W0rbVĹ1,C3VL^;XLfE/3;dd-e[p\=4qEGŖVXp|()p@.p䲺~u6i[ue"P|pݕؿ;(I_«? w/s>NF ZZ( HJв8 e k1]M]?Nc*mUJZMƦ UTecӤik>!P*rc}}UVJFE(yp `pCϒ<&54`hfIsbMMp&!%)K0\bx*HDPt>!LUED9ŀP#)̋)"D BHPu"(PZnф>]W?x ZZ̀gԡ@Vo*i)i,dp`maq l)a^b[CD!c3`tXGA*3_a m/?U#D -%oqӯۻ;ÿ' =[Yok};z^x|8_]MZw*l/{ #Ty|Ÿ>2[9SUS=aE`]Qz?aY+bZV$i`9fE"'rFm2Ʉ5#hjקׇD*qT W9eӝN9NS-\s9׉QMQfEttw4 p ;6s &~l?9(2E8~2v{\tTNg.ʴeYaY'}rƝy(tSB;~AbaxE fk51;:v<?w4!_X_L`cxcvfW=um̶Go\rh=#{֜3Cx .X#2, ˄:ͩ)nYj5ɚL<7ye%CNJX4N@QDZV{nĒ%!*d.'9>5=)b[OGZ[Dli% &,Cue ` ʟU,SgDã\`z2o2H5g0ypf# ,~ޥTլޗҩ*d//ߡ^MŒ꾷l!P <00YK?RR!! jM@5퐖B(fH 0 (Be]$ٖu33 +ނW5:`itFSL؂mLxĥJxcu!3)zqj} H4*5oe2L'f L@8<l#aPN=0̓,DI4("H^VKz*}K"~afqEc#T-p |^ۆ)>otiS8յ>83ݠ; S( ش6:ņD15F1h c Xjlm_TflG"oUtjpYj0Q.ݛ,"Jo!Z"qJ"Ilx,XeX:aL`7躤X&s}*9m`!&n~Q\ šg s^(;[𩥿'z'/w{CEI/7vV_.QUg眻y5@K o(@&Ddd,KQ2v{ww{van=x3MlwC>3&h&ބje|OWݜ7'6I9-7ӯ+MZieNNVSߔC#?\: qpppp-%"2Br&DW+wt;tm=4M- G^1Ѓ^=70{tWd<;Y( k_'Z`#?%zڲ^Α5sD;xBV,L.w$d7ܒT2M~ }]@ W^B\>9!+],Inct D @.K%wB21!lq.²pn5cc Uqvgkl)s\j`6LGW)xGqC<,Wȵyk үreVy=<5FmsǥVm fmGTھ1\czlO|ƦqB Ku{r_E)FԈ29zFyĘO O.T*^ E>5|Azҧxa V*t|kQk?n2 O@OmB< D* ~Uf{"^=fQP+`G C7f^M׈VDa@{ќe%c"~O E%_Y zX5fx"z~3'(ះ(F[Sl%fKE\kwm7Zˑk@CLn~7P)$i"ťBA [<%v,~/ rAN_PdӀ*yx|Ww$h>,64pڂV:"s*B)~9x=[j0j2Zb_ƾ:Ԛ:Q/Mti%}.b'e NjC-Oˋ*_ժs3Ü`ZYs;28yS٦yZ9X؅p.S HiURji#a:*J=d]RTT#>$0%g>}gXy؄͜vdN(:POCԏ$LeTE1Gi-i9mm^zNy.g"EE"G*X"6b#8!N⢸"[TNi2]r ZY'σR~-UR?Uk&uX}h)"I)vW+H$+.כntu?~Խ3 I=6`+G􆟘po Sz$үjzC_b34f|}OS(q2ZZ=I EU-^N5RLURqʧ<,>f( zF⠨UW+Y,u_t;Z>hMwAFZsV3|)0zli;G1|!w>hr2UUu%! o}$eH""  d!L"H:R:V !Dq`[bglFƱmu( A#-ݷلN[&ߞs9s(*l>5&?qBA~^n;֓uϘ.]畨$`#U"sRn 04"dVpxeDD1<҇#"}H_*Rsini0 Tiĥfذ QE1 =@nKaI#`׵ =:o3JK;c4Ь[ʙ' E w|"`U@E.-$h*!XriUftŶ=)Όц4yŘy|PmI(@*YU(pc\Ăz;W1wy)E5DZ klFAc-^ڟS~UL5 7TL辏b׿3{JK=c'+dIWS>p*)qF#e4$db!e\F2_XB/+ϰ$r'3KKYfǀ@˧^/mq5auTm z78l9p<="Qٖ(?.RnI9\bVVՅ@,meV_%5k?IM.PLOs#iqTZo8/;Kn49ˌ)HX-+ba ΝX,hX$;MczX[ |Ѹ}l["ZrUݦ'm]R:#K? =PVXe7R{d/u* H܎My|xv4ՄDDd{r?>*աt>M.[EWgͽs8zn2Ϯ[hBxkޝȟy?g ؕ~f~'C)˟Hj;-V&RVCoJ[N{2.#v:l!ɳ.M|h}@ r_#vIuOz-g#~*QO`z'=BF;}'kD8k?qV}ĶۛNi*Ƭ*0G;S@+x3.ӷ~ ,Wf kv*ٷ 4/xJun9&n$rlM|!C݅8̐BSF9v0$NuXU5Jd<kGکR}2 =tv_ȃ^H_Ѕ1 .D\IM.rĵ.AQ@3i_r99w%S 4w~X[<Tm $D;v>)j vc\Han ~V5Ğ48{zms stfn1g)8x̩GԖڃ#y1Y>*c̠YY#."G)9V9@k\pSI=t jT^w-Wۛxm\r/5 j}r: ?HvȾtB;$o]r$%#ȧCڀmc=p] GtS^j)ZJ+5}Sj6Bؗjg4GBR)ە;`\izChFrɑ_GJ>g w |>g૽?<sH)>ᬟG>sN-MqGʡ }>Euɽ4W /Sw`>}عKN:y!ՊC*(rS?@JP=keʻ7j-(|Ds)ѾwKAQy<}h9M1lEk;swop}OԣH`XSX}>媱I }6WI0c>} _}ZFF̻.r`v?];pRT+b@$V^h!Wv!qc83~O?~G^k?+װTAR(:w-xϸg7|S:Gi>Β*w'RO]DJ`7+iHڨ)і(yNA/)g7[nje:x1T#)YzguzWQq{^2j~@RPRU$1ȇ-Ū"RTŒP5mCehDcAH+HqDe j(EGsO˒3ݳ={}2FR Rc7IQ#5ۼ;&鮔?o#WK>dc%Q.`_</`޳`3HHΗ͗f9sld~޶_{r9.434G<v~|k^gFYZ}HU"DC[C/[6]h*m9+AN\_Mh-1 E<g4䣏B J@=n03I}Y3qޓp"xgpBT|׮S՜<֋t}ϓh0/?,vkaKDߗ5;ڈQgZi'93FϥKg'|Y3q9F|_~d3^_kK4Ҧx7a21Y-SGY/pZS6Z[]j8;$eE} fvoKp5k)~;M/g" QNus?9lcoCKݟcor:lˡ]o1Fk|mqFϭx;wSƧ2>y#UÿOdukG/iL T'K!o;U|ԑPHo!݉ UBW8dnDq~,dI-jjsW?{hlKϏQgU/CqЮ?GS55;ǡ0oP}y4Νީy\ nO XFMDmQ9Ƈz{~QZW߹އ3^~pxk!0fSک 2zMn 9+x3ϗYc(>636O1߅䜱x11*8EGdoޯK\taPu]`Z7q??ˡRjr-'WXX/] uZ_W%^9-ywU`?6g7rt:WXͻ:;s0[5}yw+2ǛTo)&)N4kSO+E.9]җp?զ_8;U6d_d#MRh_$C6sh̼y-z5Gxyɗ׆sz4[L;u-6F^#{@~:_'Rî³h=䃌54sVTw`w!U% R/MzE&oI_]]#c9\v}MrTk9#~8'i`yW'6f>lʽôFi@3Ku5뫛ГՖ,8#}2 P{us=1>Zr8qZ0TEB(lmЗg맘obǢпj=B \VWoÊsEM$7?Ɋt,u9Yao7!{Túlq*ƭb܋"[|xN3ҭ;k.lircE̤0`L7IZ|n(<3㙧'Nj[M^|o5O"G`.2 \uwnV<̷|N7=Sk 2) 7m! Ք[Yש(!J >o^_Ļk˽bJ:}oN`uDW~)V0Vx8F~n)On̦fbWw;K>UXȜc}>Fb/z;6J [AFة:12usZ!{s5Gϵ3C/E3Nq;LNyz8Gb5 ?yn3gsЉq&!<<육:LUu:!%_z1J/O5I^E[W8?f<İ*Κ==fzr927XM/To.C7].Zj9 "j2τS&Al^0#pSfL~_ ,i=GH'b"l 7_ 5H#k&0WoDDs@kG'( =0JC9wd <˅z G cဏݺ%xUqyZ`nD? t?6?&-=T:}1Ij>/Yo,s((u 壅c^Zn=eV/YLuRzŊdEeG?$_{&az=_ xm8@q³ 1H.pSШGkʹ^|n頽Mr4Y7Jk7!-m:Ŀi EEŃ(֣yȮ{/(#Iglb(8>om28n7$V6 ص6-54!q"yC%***@MST*ZġPԴaHamWzCO߂fāY}O;-бpn OImz|t&Jkbr nAR:52cz>WzUJmJۛMY]]_+Tj+PRtD׏tm¦b9`$8uAv? 1Cd#d'1Oot_鬻KCw?_KXv| bp5Qdњy jCM}u,|O th/x 3NԍD e?)j^R9quoVri5ݾWC1^bD!B裂 Ar|7d@U.!0dfѲY荟 }WQ/3 =[hE<[d#0&Z($=ܟ4 FD3ˏ^Gf*=7ܟiR3pe,]Py4妟e0+OOWW9/ \ɣX<^ `$b&HOc}"jf* (ͪ,,|' endstream endobj 2962 0 obj [2957 0 R] endobj 2963 0 obj <>stream H\j@>,EvI@$jFPG·/)t@\4;gn2Qԍ Ô,n|ojq_Ev8Lםa4[}3F+ͷ}-Qx"IDŵ]RE]vYe8_Գqx苒MĞ=$_=$0=#Kf": yBj!j RP:B+(ZH  @{P:tEHRBI#Hˆ`$aD00"I ~ ~??O@xشgʇ16^K\͉j4?SwS 0ۨ endstream endobj 2964 0 obj [2050 0 R] endobj 2965 0 obj <>stream H\݊@F}TWW+u/u 1̅o1Gfa8T']6m}/! ԴuJ-7W7u>vl|poOrc:7T֗<˾u=]v?nru:/rec/z7e|ߊ.9RkwRll[j"籷SO<%_MZ@AB gB @y(B ͡- J(BtB%ALLLO"6@[CB;hSLҢDg$ -2c?H &Lϩq̨-1Ap'kSk jE2YۚSNSIaHHM] PQj5H/<Kd.?)?)#x F$R$R'M"r]H1sCLH#Ss#8[ϔ#b=rm)~g)~S"~_O)~?/ES"~JZ$%ߜ$u1Sqݯvwnu;]={a6} t΍Of8Yc endstream endobj 2966 0 obj [2968 0 R] endobj 2967 0 obj <>stream H\Mj0 >3NB0$d68*CzOK:G;L0Xg"~:V`N7ʿT`:'Z7xVU?9¡6#o`nץ;~pB@`p ^Մ۴H72sƨ܈T+d̿îb>ӴNϙLuSia@{|Hr-ux?hH=+`x endstream endobj 2968 0 obj <> endobj 2969 0 obj <> endobj 2970 0 obj <> endobj 2971 0 obj <>stream Hj` @, endstream endobj 2972 0 obj <>stream HTV l3g޵ 6M<`aRb# M1͟@n4%|JvՀ&YHЊFI ORR@JrA:Y̻}{y hY%+z 9 ք6O/Xܴ| T5-۸hk+qٗ7.X C=8kQg"x se+O=JVX1oי~ ^i^ؼpoʺ(< @Wpx_q9 8M"8I㌁*q2ct&$P%, ~ɼdfT&]36RjXOXϒmߑQ+ >Sl ae `m=kUjBI<cQ[]˵:hƉ~ڤ]FKa9ղF:EvNyX5yGK]"0o j{N8nIG>%99QZfviI9|{|?ۿ?dsws^wkhܾ/JrRJݾ&FaË0`]HM74p('B%TN4P7mh3X4(a=K&` *\Jx(Z=.!ފ^cz %P. Mlsr|v)ߦZKi?5tZMAUJȦ,:E/Nψk_"N-{(Pp?vfӲʕtDƳ6F=URkMoIT3tJWViD gC dR90ʚcn ʓxn>[$VCٿ6Y7jX3vNi\`5|!3JjjYm18-fa<[nzwkWuS+J9E{Q2^;v٦u;̰BGhi5MY<. 2}5WkS;}ixY{asigC2 ݐx(F2#V#+}Nyj)30<]vU6E%*Q4huaH># y./a?_o:X#o݂rhHU. *&.V0a䶬,Ȋ;@_w Z`+}CZ@"‚*8ȉ H75Bʥ@`h8p!tU ȇKÝq +C;lV0@ C~;*ُQ>}KXT*~1>ངܸ%X_]o~Ewv:^ UNk2eI8cӀRE'KXޭxANIM d=qOPhW1ȶt#.ZRN_|=S|A/z'|r.U$I!!@L5 yIn,yI)#9RĤ .!ůFLT(z>@X|0(Rf"7APme[ӅA>xg|mPcJTq9_0lC|16 #( &ʛ;1N 4UѬ8E Yh p=~ëNNLLu;( EN4CPjX q=IF|h}]7 h`Xn;њ'Go{o`лEzW=x3M!bI ^GZ4PIBJ8"|2x,HASDMD|RvPUilZ(!t[[61Up5Fvi4VaZϸ5-mggl}Ҵu궻{DMK Gwkj f0L`SQY9PTU%kK#T:RZP`,,Qגn3ʄL3("<:/d:ʦ椗5|:.ELSJK HUd4s&5W&+ʎgm .t o.Qz}-| 詴}aFm؜"b[մ4j 7cgXlym+jA4-Ճvj|[[?]jnO'ݯy/={ҧde$2'Aۆ6&XYY31UUe9 BzHc}%%>K%Ѭ_9,NB6P^McQ<@fjzZS%ውe{O\;sw>iRkdеeu|ܿg\-ݔ{j#*:#_u[VϱjPP, 9|H?lGIW I5J?G w6C6JUv[Gg7GrZ6n;}Iuyz~tIģG#x4=\p.qp8G˔T P/VqHJMHdJuz]u/\] @pf^;xABqGN3_XӬεmը=*C9^U秤0ObdNڶp 'H!lIHI^ױ.(^}=*`>m5;:W۟Y/Eɮe-wہ3 pSgDZ_oE}"1W̖wy/:37܇&>gx0q+7O%B!_`0`W/WUΠ O20r8 "vV\8( C/[Y\0׎8>6_zjAkW&_a[U3b&;Zb(!Yo8 J)Ȳf!өL:]ڀvL;]Mh&<~i:pyT;{M &GњoTe$0:ؘ{hc8~]Gu/Fɴoۋs^7,2Rt?#1)U1<& 㐚GCe<$pVXP䔋 ƴs &pA6fVX3Uoc'Oo)-/IHDVD#tE*D+;oXȚ P~GU]s}f#;l0|$Cv.bea*][,-)CЀ_(*-GPR-K^AQh;μ={׽ܤBp$MzrGa΂[yQEnd%J_\e-imYXIJFwf֘+deHv6ob<0:n'n?dώ޳ŮBX&`gx%sK6<&N$AqcXxsp8G`3<#& R?f"խJ..q=F0$=D3G{9:n ¼R>2Pz$$ѫTD[=F;FEQ٭o/ s{%SH!qz^$;hw)zdǹCXm4}^;:KqGKy w4Eϰ V0Yf[O8'3`E> i-6_D}kaA,lOȠ}YiM̗e@cn5 D!7aP P5܋aJ w6ӃؖoaXIώ!|3:8#x4WcFn⍼̝kf%r|Z -Oi1xM;&8;yig ;%冮,*EȸqCߤMr's^BWOȺnhwL&N\薄Aq$yn杼i#0qA7Q4}5(Y&Pͯu= DGc\K'=z%Uf um/kͤCηQx N,*k~oѢP̥5̲g˻3F*n^,>ᓝrLJĵ2sLpCC?h4\h|GneBH\)Pw#v!h]| ۮWyor( wŊΡ-?9D&M;l F^?[~ݵÆ~[ A ǵ_^nN>Y4CȧW14`hCnZm=B"BmT]*c-.,䢏I'%/HrOEʧ+J]uZ? z2Nt׆ڍl4nP͕U+@%k̨+"j ̨җsDQ.(=Z5zϨ+- 9 jB[dpE }cP=0iT2֫{;rhaCy~C9r=TҘޢQ7\LTcWUV6XU],^(e5u~b64`PoѴ:Z{eF߶(i,3uE ,VK7' Vw)kJu1PoVjϧDݪǪUoQ{Nn}싑{]͖Fz5RP uC )>2J4A Oã/k1$GW zRJ0Eqy,J )~/nxx~;p ^r80\[R DHѬƯIYlhx?/FV3kL߽۷/:`1t}RK/^޳.쫫Gmâ#:h̡mգF Zj6Kh1JO0hoCxP T at:|MIi0-@-Ь Ko\{ac1DM-d[@V|_DZ u*E]sqP py M@9// gT!D\cY79&>ٿOqo;]fc=lr>@NZ"}jM8c+/ڄ~ ؈8>‡^(} 1Wޣ^fo)m%y2{ '>d R@@8y9e|, 'o}Ϭgល-s"]S^'>u|fl#R/MNtmVo>`_Sgvw2f͜˦,u3¥:='bPdRcڝxoGL1s(ST^mtPf 5{(0Q~y!jT~I P>.۸Y:?mQT~v_!"+ DW*;1Ԥ4dBQ17 N4]'h6Nˣs.7\\s+${

@luj}Im{'>uǧշZOޥj9ջ[ '6w^GqjǼD<&i#Pq\y/xc{^9r5uw}fIJhG Sc-Z݁u?boAZ vĚAsMeĢku:Rpglgn~7xzݓB}:EAO2yu<,̤V9H{"gQcxcxݻ ݸ6:y7CMկT?^/؋fn̓1}y:FA=>*y!;qԬ"fBT[68eMRՓ4@%6dXiSF)`0 :/ȭA"r-@Fj!M zK;H:HVb:n@ `nNЫ^%JJ&^1W]:jJc&Z|Bc)n8qp\؎vNLhv) =e!cde{]MG>+B#&)`r+Nv{H@P*N|F9ج[Cl%t?D&*|boKVO,_-S?y~aj'Έ!1&[-]ݧ!=h[cXF513Ɛ1f\1l#_ߴ3jbB_/K} y3ϘCyŴM36 #_ Jdi2M&ɎdwrF"9tr899[z6}R]:U*ժZj>kUc߲,Y3\k͕y~KzwhAO@ܝ/|I|- h( `wPF xzS +pھ/րx/6z3!omHܓx{N?'N-mVO)<,qTԫ_0xX88i malo[ {CЬ@ chog}u'^,|Ŷrom+gA mI5:ĦK[ +2NE!$#yI̐N$O4Ų4nCv󲹗lZbC#Asoc7Yo9sKGC/ %3O?y/o2OZ^cԛI3}4ih>K$ ktB}LOLthz%id{ %vk'Q KX7Epc0j-v^2eiȅ{-} J7ly 4^W- b_蟉:Oo?bz~e)}Yx/?saXd֤ Q[#q} R#/QrZCe ^G;n#KvnE܄I'qmBH xL/Of f;M;-HA:5El_Hטc$blG43<^9Fp<݀9Zܲp=e-gol/w;x*uƍ}[5v(0kinw*h"W6+I_CbmoĶ!_HW?|+s:Re57IVMm5#ĵ”fOّ[]X傗oOgsɱU9YVSSS\NJMxu*ST EMf+5Q+;II,kU6+\*V ZX=ox>O/5%í C8 ̧WVX\nz!x* b0a2O_xE P,p7F;ōJ hs endstream endobj 2973 0 obj [2968 0 R] endobj 2974 0 obj <>stream H\͊0},u!mcV.qjriHw?180$ۓiG]UW(0rW8nNGZsWyS|Y* zk1آ~?sL"8şQ֊]m O)"6ߺpҨb&EP ZB'HʠZAZCKheZA{h :@[""""""""" EE2 eBh>_9eus8\0L[{g{K 0zر endstream endobj 2975 0 obj [2977 0 R] endobj 2976 0 obj <>stream H\]k0{Ź\/JDЮ/~M0c4o`sO2D hpu̗D2!ݩV}c#> endobj 2978 0 obj <> endobj 2979 0 obj <> endobj 2980 0 obj <>stream Hj` ~ՠk 5 endstream endobj 2981 0 obj <>stream H}HWd6#Pmi0(y 0BkfhhIZ!4)) IC aB'L NK5a{ ɞj{jwoCiܒpGV/۲)=tfeuC/]vW#i7X6PUMr?Ӱn7/"-ay\dkp_nZcs46h,~ Ow;eeYIN^Q8AA$eqk}L'^5kOPZE 4;"|!Św@f G).5v =EU& \{a.aZ1YiJk]Z$J1lb"Z&KraXd3WW}`m=vZe_|Rӊ~b́i\a'p?R7fOv &z xA̛duߺӻǴ'_CMũL ~D߈)~̀Q~M6!t.&|s@2k{i5,ckg;!ZIW$8$7,)kE)Nc54r`CY"CA"HO($&eQUDщŅdK{/Pk۝wn̝\3R1&/責,Ջ}K}2,nYd;#! ^;1uPuvq,vI֑ |$9=TYx \ 2  ȚL]U PO**RNN=2mK Z<3kLJwj2`C}"^Izō>D8vR=WH4^r=%m\ΤjwVWjo{Gv*N5moo7'׭=n'LWSJS1ܙXk6*RtMW(v ķ j l]_ȚIƜ)աL k:8Bʡl=SiLYw%NqC-<%)?]pZt ү6)6O̓oc`'uPԡ9Թ:/0Z*$E'ɒ $Jt%ouz|4gS3F̵?xfԕ+S_XO^2M^ղ:z:GIuaA]N|oXPkέ Nm&L_1 ]xso-:ȧXgӂߴ45i6 #КM}&h%L77oϒ?, X@.z3`agƚ8= :-Q-(*X:W޴ҏJ|BdyCK7ͦ /p֝+][[6ܻIonIXtmC'B01ŒEbZWB֊Eomm{mW+u5IJ`,3 bj9ԏ&pf7IZ)mպJч _<+(@P#|tдTn{|(T޷]݋EGypq{3k[lh".Bze6y^,>>ñоB2vwik(9^ qg,ǩ tTxɆL==)$3ɒ KecG{GaϾ]-w{V+4[9(NS<°a=)Ic4َFFp5,o0 ݫ..꫚8G~<$Ì;A&*B>]Ȫ'`Տu,)m3 a qgPlaGMsqi 4ZBeC#=.9 ;"ܺ3VζyR߼N?ތd[ΗZu[;iM̅/*!!WР9L.\()SDeœ .z8Y[r,PYQc@VP`yO)\C5J2p FJ*T 'M4t8Ù\ q!Uqq^rXH6#ư1 Q.vZ£VW U@qz<9E*鈄ȧdƓB@!QdTR3SHX^[df325+iyĺO@&<\LYot6lDW|/Frsc~̅1 (h>W(cmmUx ֎9(>2I]i*ϩ[JR=z& HT.r Fw.H6xIK}"_V.S=ΰ*?S ]b# jsKBZoAB ElZ!UB(H3b%b*RAz*$M/Uy۽ݽ;ݻٻ$ x3845c(*IM2ShZ1 Jjꄦ #m )F#6;ν$-D6"^BinW ,Oc7 T6Fi M[HХ"Pɰ0^ SOmXS;_7v^23yt4TX $^=F"``je7HkLxᒪoEG8oL5!+w6 ^vaaחw<[Gb>*ckOFrJP@wBr;vAC_͟IDFjBmoR%B +Jj`k'>GXp#l];u+Zƥ. #ZFE>Y8"FIG}uat |A1Q5s#Hj;G%=طX~%De<+q `gtf8Kw_1$D)4?}.vRu>G΂}ڷnU7w,<'H)gTQ‚Vu{A:^Q7ڜ.ȍNJGJ? -,1sU>:LSo|\hZY7c@SJTjA[ddBg$ q%5w dFx iB1곗 h3kѯ.;d?La2xQzs@P>U񄹔,)'SǸ@ҲՎ]=mbf~ΣlĝOq(tTq#=82$cI $J J h' 1?C^{dR,?@`f}JEg.X'NJ'N_x\ZH0_/m9x*W. w*m;Tz_.}l^7{fEEA- |*0)Z\GrAQFƸ z[k"k0.8"#$r57ze8)̮#H&22:Zipi=ʙT-'N"{}䞹,ms!L$¬ xJ;I$KuͮgٛN 䭮sj#!`i↪ݭ?u#uxbOO=b0'͘;e^j5}kfi\[%Eo3pnIE0;^/&I;my?$(,hz)x*aY泙ĵ}{2'!i0l!NHO[YwB+2p>q;}Zö,?/1fQv̮H>iPtR/J-BAQzExA=pDMlmc/HhRu*;}DHgwȞZa,v!tgBE>q< sh1 ?0]8Sԫv* J)RW>}eJ]1Ǟ LMRc#e8 yrN?(yw4y^wBYwj֬ٺQm 5KX-89HR-日p*RVZҡd\/eTh$˓,y[d|ejB?x/I+\onmι`3=ٕDqF+7,u6;B~aubSW˜md/XKNٽ uuEL LkW-$ws 9(fI\H큮xx2ޚywnKTH#U]3[}LH-RTXJ|>qWĠAP&=E_ե88ChxCd1TP:Wsމ~+IƁoh嶧{;y 4699ӵsys=նnDR: @6CwuZǃͦX]7-CuuvN?gCz?dt #EZQ6QJf#1^k'ĺfxRnD}[Ut POn%&ߠ>'gpwA|)V˾5J;Pי-NTU ^SdC o_8v7=_ih[]߹D(Y_9ga;f_E=PoB1KDaG|uj-Q Q, Z`|$XCVt93399?4= 6ջk ge2qx0 @:DʲiY^4RAVj^d@tӧ&|cIɑi.+T7ŌmIrfyӤf(Yzz*,b[ڊUQšǜDS,1iuzgE)C pBWw*lk P[#bV-s,x%feL;B˭YB?'O{x~[\A5i7$"eh tEEV;R RmCMBRWz wh1b+ Uzp`rbFuPQ=g[uu臱I!ZakD吆x:DY,/N8o_<os q9Uxus*ςgXYMW OsD> f-w+yycx{-'ֆR)TMgnadNū?]&$A$Dty )!w/a򹜒 ><~ڡ5BX~T_Z$P\Fj)e:>l(7]E>P[ M*$*,KYB*kA>" =%QM5 J\_\F,Ļ F̈!@^ީ|z|5 u\"ERI[TXh*ق%<8FNV`#yǽw;'>lNrN&1x4C"t@"m!Pidk)R$ A[QY ]6k7ZMLZK $,N=sy84L8le_07S64n=,  ̽-w^9ysJ;=i ׵hKw1GhB‘H "@0tRZVuðee>[j%UVJ $S> jJҡlTEAڰdQ+ dA벎59(L!@],WYLi:E'Jmk;oZ27rӞU}s)fǤiG[guŕda=]Olf-ݝF__`v/rA˛}IoH$!]V3-BE~UEz5H~]vT| 9bY_n[ `+Ix0RhiE6,Q${êB'a`iUhģjT( .\C%*Y#4]v":%/p\eY {ݕ,q&$g*I|ӹeǙ3t7.:f?M%;>}mG=-l w Yৣۻ ȇ/>%p.'TyO>"]>B E9.9 &\rB"e E% "L*Dc/}VGUR&YbPC5[a;S5IZ*pd _GwD\YT"N!r,Nc$%<汫lhly |BP#/@nϭ>)|%}XIeݒՊ(<4{JssC=Kn ojD1BUɱ"gǺ om*N~u1GLj>RL;a:\}iO~a<^x̦~rtGvAmRbX͏q1|z/_j߳=rf <O_^5%N/uWN4cMM3HIiuR-B7@<I%?uޙ~ ~MJ1\|aMlu.۝0߭{~xK*JsYҩtpiNm{nq#$2g00XQP_oK>;󛪪+gYril̖y9-GGxM߈,nέuR&u}ojdnfs :IV$g%sF-Eȅ// Bx?7_mLR?F IFIFIRs7hJۜJWeb{18ΘBd,2F.ʷmR( BP( BP( BP( BP( BP+SN`4]f lYC-;ƚDK>oӜL\/e n}-37mYCy-(wڲK8C)A%J>h0%&sj0EY<5Jdϡb8dķ3 k_F5sf8n8Ӱ%w;ñ&Pnòh8wPRaoF96q\?#hVTL`(m9zuvJ=B7OjL7bKK\c)ciWl9X+ -1g=pN:A.,m{lo&,12?9~m+xUQYe 0ILjԣ_I쀀Q̹UjͼZL^ GKL^Ex0.B!\3fFr՚Qh3>fI=C&i[m辴WHZ)ԊS#-a^|-]Os$ʫ`?NH{Ws5y{8`Fy\QӂMf8fcEf `x(f)l 1f Jf̬f C#@]܏m}^ sd<Eh+4_0$|Y\ ? F\F|pNq#5ź/.hq7t'8 űQ<fiNRJඪ@\[w  o|BXyMBCeMObIp 'pd2ށWR= @x280fE'́mi9̆8OS `:ogc_;a-v,vt >b|a<_Y𐾩M>H.- >s8Qtgxv8~dD^fq&N\a>,u8[|o*%/f9*Ń¹S%rbRՎDs:q|<<1X O.+<(m"\EGaI?ҟ"2DZ_Cw 3WRJVJX;QG~9a+DkuW3ڥH{pN6Cn$ҳl0{=I0=Z'> 3Qa </v؁cЍGZRA.`:~F~r]gOl/;ӪokQ}~O,5uRѱrz-2pG]$1|W PT>]u} EW%*U2L\@-`#6:6hj1Ƌ̂M5Mc4F#UEgrݻ=s39~7˼__"Fqb(k2ZDd.L>+ɵp䓴_K>"ސSke1Du^FFKyYmVX[6:̌5G/+铼ՕI;cJ(`Uc zdk$i@~*3MtK xw])._<Ο p͖kw<4Aѕ+4Lxu:8/MK_' Qtc(ts5C1dpi)ڀKNJLקwݻvqT̀^̴)IlZ#llt1uAs޿ivMjcilV5tE8|S>eCt -Pfj#| ]cnLV&5t/ld,=;K2=lޣ .s0G KɶGdUi$#gnU9P'İ2`j.͵zuh!l~Μ6+B6jG{A732!Cp1ϡGee.YB飢 BC{W7D|T \UU& Ќ)¶$n-YPnQiIk5ύ geA-`r[XډsemGH)S:*,h3US @MxN|4{JE18Slg`=Lu9e?TP ŤO(bݲY[HfnFgzL'we(,-3N((е#lTDUՍF\@G f\T :+neF/^֕*O 5 ,ب/;\asmMh6ACq@xF*G*CWE!*"mso]x}^`:1~SuoMg\mbtJ巜-kPGM)r6du +7m 8c,C 6`X x pPgӰ98>M/aq@HEFaZOc1/wa g,ؔ V 6B^Z0.C~&BbOwD3K#Sg`ѸmKcOuo[:A-SFeKCⴳoeORa/ti b'nYGCtvab܃8~P:>Z@ka#ѐƦ>4-&P_P[QiPF CAšCT*300X Ϲ~9wǹ{Nk0ˉ@,liA7gky99ּ5O/K{ ʾ^X! Z\ݫuY+_ل5٭!@cjCg1&̸AQ_rc77x%f465>46kh#yM`/<^h̪[3t]-wcO}n:Ab+z4U=\'sR1HwUl?V)X'Un*o^kJZ/? t,1vvJR9jʙE_scMfq.Lt/4?T !HA6g-GD7[/";X3@ff9#9O2wG+s^iQ.K]+:?r\AsXJdiqTUǹ-%ڠr4ū2$>SZA|L|LeZjmS5?jyNs@?->tyeE|p=nmbANjR㯖`ۃU2}on#cq==)'cI͖.- ]Ql̓rhWy<ݻNlPUotN1ϵ&eE6S&A/bu>TvطI>ֳ/ZaU'Ki"U}HAn*{n͖9pc&7b|U/,v|"_0'UF:\f- ^娍ȍ.c_Zۓw۵ a[p FZcriO o"&dllA%vc+yI+Ov-Ay3Gg{:{iy"v4cL+@ˢo6nK3r[f?,$+:s3/W)0ߍ<ʳWw.=o?\(>!t KeA2\"Q)>d)t~0un\ 6O[w *Wmms,T>g8M9?m"Y5@9lRu!xI,^LLe.h N},kѯϣ+3G8O-;|I߽O0BKx룟;<+1kbtt{-Atk@yͷ,ۨg_Wԯ݊tM29ϯڕW죠f&P_r)57]>k5w4|H.|Hj쩑Q]K~]JМ{vpڠmN THǙJ;&/wv\eoZO* жּp܊Kxqx*~ڮv\}xǹZs3[OC?9~G6Ss7Shc~ &]MeJ.wS|d?so=Wdb*ƗE째R. fKEYܷF%ٌN-,jntڜ֙uqEgQWn`w,k󽑎}_eqva+$vmI/ۺ\W"] d/ Vpx VBėk~.s;SRu Π7!Xˤ`1v]Yg7K{Ko{9١qK?yfx]kw?xd0~;_5F=~os7 0#݈˺pZO)s'66 l8 *C>RgNZG$fO ޻c^JfnoS71{=ޡ g4!1\>?ش[{%HF OBs1?~cUJni#@, e_bG[ڲ-}4whkޮiz~7-?vKꉼ p:m8(Ǽ2cooGMg#oA`}{U`'xTG}-?TiS<0$o iz:MЗobִB,~2GҶK#ʈ#矏a6jrfEeJ͵ {TPI_a? |ޜ&ÂJ8"Xg ynPXO"4޿cE뮮95̽u7vA_BUR;WM|IQ`:ږ`Wng{ى,>RKec\*8~vw.AQQ@$ն(DPX +Q 򶵥H;(U&JJy 4&w%F!J,v>'Ivcv+.QVr^hoFh/!NH0.-A~{~m(6zxy`צbf5KSk}sBз:\>[F^8.Kzny0|_NɓeIL|ޘBF<:[2v))&|&kΏq^}jYWoH,9 uɐ r]r@y=$}z3#(/H{ô yy:Ij4K]`mPSx渌5P(?e<(K(Aq$ѣOm1o%@P!kKxPf8C8dsw.2'֠)DwhwƏ֊RHNgy}qJ=cd|iu{tl-^_MLKPN7 'JQ,KA-y&),oN[eA"|XToQ 8 ;TI7$1Yʜrvؓ-'V]]W/2O.H{Ȉb*epa/'j 8Ћ6;= wq!z y:MNA+7rֹa)87w_sf9Q q f;m _@X{S$}],BEj4.cL߸ WaL}Roԍ!y2O.=UFsX6(/2@ ) dU l<ǥ4@\nf cEw sCȧ eXur6 f{-ˣ -E;%;sŘ1A^αOdFd7BxC#P=%2No˜1&1Âi?) F_ ߗ M+/H>w;LW`cFb-S$2 @S A{4/'ӑSy@^e"~ kvS?W6KKkr1(sJX*5RNqO{\zMV{ػFFvgݗ7頼_`-_O|\;56Xݢz5VeuHi9\]8NQAjMi?O77;#񃿀Qgc@ܮTW{C 5>q1^[洕pzBy(,Mbv-u'2%`~ssD*М=?oOcf_ly!Ǻ2wW^%=P6wk&N `5<#Z!{?䄹/"ͩ ~VO6äGgoue9@Sq5. ̚|Ӟ/` s_riκLE;4hd>ޅR?mGo]k?8K!k-F2S*q2<"Mo]$gyL74鏜|u  km7nLK/wۥ__'yl?Cg~aKT{R#H +MWd9f2Ro\ma̕R{+<{30&Hwsg>(s͓ZK^7&r`[ w%}Ki`g9 _SNIɀ꓉Hl8=2zd 蒽p,lQu2t ,SO]a&. M#d):}[?8&,uv;#zYeѝ07K~>oͷB{~skn}Lt:Ɯ92q]膽~^WH]T fڝv)ҺMY/!NU?7ݷm_!yWw: byP4+`Ӆ\p uAs@] F|v9c%[?\54/@- g}==,P=!.ebtv3~L֎3]dv~%:  'vlnf%/ lON7ȵGElSu#V$dJO|/ ~b'yԕ~,E2_{ˋD}fts\o} \n{w7w_p^_^ߐJjJ(@C2}>lg~nض¾YI&>J/wܷSz{ձ _:(F7=f$]%QḌ*M0So$s}⹎OotL걿nJ2R%ԥ\'_Ro˟􁔏vARޓU)S9=ǔֳIk[Gkw?m_VS k?PM rW'i4FG}HU~ O(K/`>KtH<s}dhރ=H>I[?OihHx>}p+z1&4c|x.S h7ݖte&?O9N/̶tPxx[{c4ށQ*$֣-4ZWI[1dE;us(w]ԃuYs uUjQX|xCie*OArv>`5޸oH:> ].xQy(xRy ؍F#&F(qG%f0w07_#JH_R9m&JBjN Z#:I[f昒WBPb],}j1>uxEeki\V͓nj崩dSx39'+0+s@ u@`%qy;kHbuwD EX pg<;z \L4枌OAQ C8\2tP!Pt_^s[Ś؜EN5ĒӋCb WA:!C*rU]@wfw+"Ldw<-LC#bufۖi&F:v ,| >hl&vhm9 yzÚp\ pZm [e_C, fL2AKo%fF\uذ>fX ,_*軠_5 PDkl#{Y5 6460]8Gu}S@zXo7M -}AH5:S\It^ߵҗnꋡ0 n2}v' R=HjjAW#jdyL䫑Yj$[ԼZ%ih&heㄫ,SIwBɍ N L V]ͭhڨV|=-NnNN8KZs,ꭥ5QawњfrάblΟg%iĞki3*K,4;'j!,4D2ʩEPʛ`x)dɡVilHv2#1tbmHQX.dJ>_ϝ&HxeߟOz2m2Xgg8i,i31SQ_vGJ?1em3s3gt3N5W*'McuӁ+k8s%\7CӁCV\E -军ej,ӫfƻ^OwkCii< GEB?%RMҵȗ%Hxd@n3ɳzu{d>8G'ۖJoZz)dt|_f7pN42>+ MS™7Ғ>|Hs׽B2ZM-z~r}{Ql" |\1 uou&\W-rM67_*JCnck X_ S ԛ &6A--\R@Pg :`P ٦z&?I)R_h-6M`sS endstream endobj 2982 0 obj [2977 0 R] endobj 2983 0 obj <>stream H\͊0Oc{(jc "6]ao1҅~$$4w;fv4 7]ڙ Wi4d ?4;[B | \ꫨ,nC=E,YCK==Їmƭw}bv|Gb;F1zhhkM6W =92ͿuCإߵu۹ػ푌Pq/ɡ-$=J#N:CΑ]";A+ !N .A@\rt/zPAH#@ tБ@G HԢp'PDei 2HdHqk{rns:Z7~D,z8E-o+Fۼ endstream endobj 2984 0 obj [2986 0 R] endobj 2985 0 obj <>stream H\ۊ0@z}XlKQ!+[I m!_l]8d͙&Loc̥n>G_s׺Irk&Sy\d0Ӽޓ[_nn[hT?}=݂Ik*;cGIlpNeO5$,fe꿸q|)dzfˑ @shmF3h \rA4"3Gf992˷j$`dߴH$3h h!Yh9̄J(/HAl )> endobj 2987 0 obj <> endobj 2988 0 obj <> endobj 2989 0 obj <>stream H y@' ٿ@l endstream endobj 2990 0 obj <>stream H|U TT{Qd>E+qGDPjT j`(cTҢi4hL4q_P-n5C5Xph\8je^7  $:{;u; XJVשF6>?I3\+yWGb/C98\> (t#yS2h ]ӊ这ϛ.c3J^;@; 6mz $Bl*}T#Ú/F |Tڕ2MPqZ:B{7!ZŁc`^gޯƶ=~xva;FIn0ܣJB6rGxm0 (MeⱔVU kXoJs+Op|1GWeͷaC?p,;aV 36d})Aa!`ZcYBjo5A>3xWC)X7)B~³<( [LNjVi7_W`AktfL%J=iؠT<8zG6ic=w̏=O鰖s'#2LB1DY!eG?+"|1_FWvv m|OԇiH7#DX%6r\.*]MQ'yyѳ³`1vX8 *6N/.zVfh%#@KF/luq+J~J\w&ce/\' W~./`$5B(3 r6#%ⶔZVZNrGv*ON6sT{5[UoMV5hOkxiZP{hHKeebeͱzzVJԅx܃VFUP3o#y~`j9Z0VLzS֪of"ww6sc0wLW^{WKsP7^f[ns9@=|#Gy/i =7q©#%s?4k2mVNZ8ڋ+"W?{P\]qn"oƞ"_@E{3xb-57n2OA#AaQ!۷Xz#gp!7v\g(c{iiV=cmӇ+yAcX]< 7[ |̬y݁Nsrjߒ@gGc{h~8Z-y`{ Qz>i{pk^6,!2J$NiEZWìFsS5-Q=JeݩC|.$>τBY(E1)@ޝ%-l'*~pVE@oIemp""̐Vj~`yDOE>8yeaK];=oo^onYPҭ6"^K0n2#nF);9 1ÖmI1)uV3rkSM >5OLʎݣ{ M9E❘f_6HWI)FH@t_iLgo+?=@Iwz{CD@c3%%: +A {Gŝ$d8tHLb =%^Qu-ZBԌ罄ǻTVVWr[#]O0j˒N/Rl˲y:1Ϗ.̓EKr:ҍ&؊ētXr>-V*!"mZ&QZXnfo$#+πc%7TxBa+YfO,gSёCѨ\/Z8AR%۪k„٭ꛧV|uSU~ߠ8&/k7_J;{b$'2R&l&F/#2 y_s'DukzmS50an$LEu%^r{aZK?~ WY?d6`ZF/`p4ȋT :ͻC{*>< ks#AHdnWd7e5װs֮55+H'v^K6ć r=OUbʣ(L%28Y_ANtT\"*r)X©ݡ:4o E $줷׹a:=grUiG"g=a.K]MF 0IX/e% j~8$1Z? (Y ƪ@M jw~zL*YQpF^(w ?f?*^|yܱgslW op)Pjbc1g΀qUlgIɒs%<yd99dUhȢCa&'S1eYJ{ *.gr885{s=#?訯S6:a;Rk[¡dDf#o%үd vۆ T%qj(gvmmmwR)lU[kk3 @x5Yq|db }>kv`N{6'zJm R|(Dy}%KHmg.qO?u;>82 xJ(dq@HXJD#j*lFu9 _W?gٮ2)#B D<]/mZW14mBYTH6Ta fdR* 𡔭ˣgqL¸gXv޳cYuw6hv^|H7>[_,yn;ɝ]TFzn!(W58 SXfk ZQBFe3x,kK]8xc,b2,B&Fڹ./JܧhXcGEqb Tô3Һ>ҲHE7҈.u?įq{owSTxyIr8-?\o4okxwˆP{ 034ê>yz* MZ5גN+_AӔK*bcբaޣ0wXۓGv%긍FCj,Z';`aJA/!688-h前D["NLdn,s nElTzU %BHOHW mc<}A X3-}d/2 {Bpȣh?䑠IGǃαq$i'.q@)?g+֊ᛟlx@mQj Q}A=[Q+q9@<1H,\CX(yyV3^G (/Ņmq\m+ť⮏MWyC#x ה3OB&R$A0Nl}4Awʯ$)>nl7TIQI'~:c1gRӦ8H3ODit-hL ei Rx'Z <Dn`U&HO`kuI*YKLMHR_􇵏2p9C1`x{ T$a)Nx2{8=TC$dլq13w//X?#R\mm?~ pӲi5?_˾.n kW%3n8"rg8>wgpazlEըXH.˫"5S,EMR؎dd KQv14#W֤ &$ 脠fdMQɕ&/%A>nJI~ J;^,zd&_&BLJ*q* \Zx.yr*Ц$9$, F +i^$5-byzzK CzGddÂ̈4u~=<'YT5}2J'WgOĉ(IiX`,Y ^z ^KKUEl}e-VxrK %"q 0{϶u06,dlXĤK)P6*Z9%N\;Sɺ?Q&B"!DB@m3\q;2w+? 㗀>y^-QU FIԅN`7{6'==z] Ѡ D`T(Hi8"#Fʔզm17[&7gbS S EjG_lBHYW\eUS<EfAzB 94㋣G_9yڞ RsAut}LLLGE1-zv  .rX)k|Qs.Em;TjVLm=Jy@SsH/ xMRrOyiM3sĕ#YgZpF{rTMih^IF@b.Nh-,nڂ7୸yiQl~S(?Pp&Egtyt&g͇>9qL'CK&DgbO}]K"U/F֕wM@^W!>3N܍xS Sӭ=i HOdI ZY3cj7&1JT0K33+v_5??N"W83cŠJXaOɌrq4Eɔzy1T,ot5_WCsX35:ђpG Gj H>7Ę S:H.8Ec 8LK _I4v7X*.EؕTT ժ *Ta zڹݙݝz ۏdq٣uF%Eĺ'g8hO[hџ xc.?FZ`lZ"=NQg$(2 #_&]gKNE bBvnl3OW|59@cot7&]Hs] :خsqL^Ig~AX`(!F&2Q  ˩ Y@x(R`$3Z_}ƾxظFewO { ]h6)LBQV7ʯ BoizGdk5rIߧ_eRZr1j9W@3 "U%RUYUtlFX,5ڜB6RR;AthTy\9B̧#<@X) LTѣpHƵxuDڟ;?I:_~_>`W?f qۗ.6β &ceU!B 90<#Wû^8 LbPK 9JUPUV(xk+~$3sCCm8~!~5Fx=qJ\D ]ΏLR)gֈ"E W׍ܘJYxc>\ѪW Hra\ܚsamXc8>jط50*a |DG!xQh,2f jK^9'>2{Û] i;l9M 88`=wکKр+u Ǣs| ζ,>%ydnօd~j I{m\U}&ʚC=!o~4ȥ&Y1C?ۿY*1[*󥗉t5UFXʼnC"!jyʼnCdGV ᐢ4m_Ks n-Pt٘{Z ( &SBabܰI-(x1R> &kx]{P(ء?7- ', hl`t캶8@!5|7@ϓkВY&o1%}bܫ/mx=&F ~"Ncb,Nٶ"9;rH;&i:4_LsNJM&oڂ!$4d>Yh^q1Gd8a?ą=۷>}{&Zo޶>`hhp`h{^ͅK5~KIWҟȩj]9QlT|PSt?Gبe Ύʑ8_ݞk@]p^*:JpwbNC60sE6fo =A}8&ׂ?j{o|oY֔uzCKa/z#t% s7n`ml|[;|T@#ok3Iik5N3.IĽ|4yGHo(?!]xS87CTsxuSt솺u7R/;D~@ڢ^i㪧/mUw.?noA<7dQIab%H>I$?A@z޺;oFĕ-_OG6h* iľD/rQ 6+}tN{Li 2<>*c(6;2%iTQ@XXHP2doU fVg .ACSM`*qY%1J (VNAsF` Dv8dB6^H8ZrK?a3ERtg.(EUMW`q%3jjʭ^O0:ڳ$e&;'8 n~#9 lWl!$dU£*E.Ԗ*A>@"4PBV:6uԲ11 iki :1wdڢ?||;a \>%C |WyE=)O3Z,ݸjNEwUvs+ y֪v.gL~PȺIu7ޣgQN^8|5NYLmUoClR-2<*iu3ʙ@2Rd*"qqނ|bAPÂAkKތ/p65L'8,!/vzN> Z @pV{"S zQ^D^HDQ1~% Z;T@Vm"R-Vh瘁FˀVyK>tF0K .4xs建+E}69s:]+iۣ1((r}ּV~%JRc eC]&B 2/]©t 8~2R>Cߴa&S._~Hă-&FP|4LѤ=6 61M O % R1[/ 8B#  L̖L_ 4H$k5?9VLG~0>xKx4Zt]7~ugm-/^^$ΘEo֗LpYR!RbY6(caa2L &ʄ[0aP6Btk̜Ym- Aa&Wz[q@V1}ܿ~ ־9ZB_yzۮ i'YiPHL-%ϾDzl}߂S}FJk$`d_=;&=XRw{L~(D?0"^Ŵ8 Kx/ixCdt}Db豚d"2fD$un0}N=豎ڃ/zr[vzkw=SzgS"FpUm[1g bF&GIϓ%|-?N^'׹)hwBm̓FdބCG6-oDji[5Cۧ715KjTKZ \WEJi3{Wk~`K?@:V`,t^=:݄  8tFNT7JB6D"~@bR1(2@X@^ɌbD Y.UUpaՠAeH fyqQwW- ڷ` +X ƛp=nroު'>0oIi.'CDQs/,Q@753bF͓8Egn x e[G̞`O'a*DV[C [ŒZ2I/834 TpG\Fo?a^IR>)#^C75:Lyq4`Rm 7 _WH%UĽ ]$ ~_d\s=nńfՓ{-KDn̚関KwB-{&v6q{~~>9N;v.N.!L~@ـF`* M:J[(hڬ+ $0Z6!UeD ˄ C,{wb^vG3 A?#.8y`y,w?K+HUh)_pzuX!MB*% ŒD"戞ZAL- !9B1[ ztO9G~K fkDW mgf0̀G?eǨYK=A?)^Sz?C??wYagxYBD< 6'>˻ Ah"̧a*'x;.YfJL$SHVNtk+өL Y<5JbEP^ uZK8EaB'͗ }$ъgg>=tOŽ؉f{as}ϷK?h'{ewS$=V~G$V8G}[ gey"VHAw#|)N'nG&?zUD"M7ܤ=xu7F`SQF3ӔΦ@5to4' 뇚PhJx;Gpυ_,Xvx0$ {`>|1ڕze鶣eLˬ o%wjYE㾳NJTL r!1X2ɤYt41)_ T*+&Ĭ߲8sw߰*HBhŜQGIT=)"Wf mUk^[R|dR.r U4Zi_3Mǧmt4/:K(tMm+k7 V{ًt%#wmoD8j#GKF".e3zqƫk'eCheJLBf*N؊rb+r,SMawj wY 1|EC2[% [ݮHǚH'PM ,ՒZmBbyF`(88Y֬X2fAv<(D2MM+MOkLw`K $FPMÛdJ~ʹ{Z]f-g[/LcS"[Bv!‰ӌ~2ai_zڲy|r:s^YYŽiTZylqC|:+U ]|Dc I^rHW.7n#7:T 1 ȬG'2]YfGZAAI)ִ*0N^j 1Ɵ&*T2DQ@R&&y`6>uz4"m k`N"uVie,D w/g~3 lo \[Eſ%7A p*95yuX$9I}g(" (n Tu@k=qVFs=n?uQ71ƽt><;`&f"V\gg!T9I4Jv'=N,:499hAVA:CF:UxJXÁA-ĝ9 e$ۖ%E`e 5:D4? i%.]H2 abpH 4|vHc@$(wS6RRI0pV*V1Ƥqq*ga&rf@5A7z%1I]y%H'E@2IYF1;Ϋ=(=w]]aa!,FH5D؈V ft;5Ƙ$>R+FfFIb4N'u'MicE]JE{s9wxދJ. '82;gY̎xgnШ2xDZ_Lkr,A"\BAV!n>]"5Sٛgp$6-LתZ鬼* $#P2hz2:q.Eɔ*X-.[?k,F B8Ʉ.:;#G ;ڣ.UmP7_ Z>rhPf*\Lj;?h-@DF1kM%3ti%v1RûG])mnG1f-=Y9Kt4"b; {,ANK7yyH1;x Pԋp=3,~{. 8::` ?v,T GrA.dKExy❇:`,}v|uꪱVqiƏeɌ˿/UT/n\ވFbeue뽩SW%ה޿]cM+;uۑ#;(unrqjq5GEikDCD=-N)b2Oz!,@I v?]5ȁVJ;SrhMlA9uBXjb ~3;e)=#AO @x9O\0}j=O.RMC"ή\|}7~eZJCaSdPN# 1C6B6Z@C;]kQXx&' ʄ`0 .sO2ZHoI5rͳ O'B5UyU-O}]m?vO،6)$UJ3z*8PToiN(y8S%'ʆn@2GAAJi4QZhs3Uz˄93-f?Yل O> PCjƷ ^\IK_b[beLvqUUcSwpIӞ wi`Bɦ![gZg,>.hڝl. m2aGa%+ڳ`n~q'zКzSA #\ :Ԩ6&6yR/[kԚĹ޹UUC41XaJYLjf3~pw_BeeTP#q=ѪE)uc*͢LHC {ퟝC@8g]޲eX?ZYW_=ۭ;_]>X&v/[ 0}rsٶw?Mɂ({ӊV&K6=`)F8!9dl!V2$/1yNn T N|?W3 # e%9#Ni?V3D8y^x ,U(P zhn}~?Hatbf_͉:P[ݾڪ"WY=qƇwɝK6ZcvmkŸ лBl xZ똎{ 0{2H0d< b|kh ,K|n-1HIbj|A=fb]V\Ra'H6KF5Gʉ|`c92X˸/6Y"N?gYV!*' 7܃=JjX>gwc/+dAMXkbۅ_l bo[eS+=-wG$ | QvE"g9 d%+a|f[U̩1v X=j(Ya!)_ܗ}VUwA\PY\p M\C c]V@ICj`Hk$cX>/Y b!!m]͜ l2qtHvR{{zeAo{=99'78%en\_#aG-E2׸TQL"{p* p.>aYheryd1;n>SqK-]l2ײhǩT?/jW;^v~F:C>c HǞdR* [R)ki_)O8/3B޵e~GK~=rA㪞Cdf| t?778f{9.LېrYck\]]%Z.,$wdW*{@=g>7AH4=֛5sٓ}Ҟ>6}p?ָv{0{c]!ɿG@VϺ )|kܒUݸx}QMdW'9C/%n#Y/圥2?iDϏ_/FX_'enP!Kj̒TFڎf ѹSEz^RՒ*b~ڨ.c^KFdc2X;2Ai_`Cd?Zx',reU wd/ qQb/h Qd uߒ f eL-9{_rLMI5qBBt 9sso:oy5>򞩯ڪgsqMFOBl- x;L^-kl%<&ƍe3?Q 9 5WC]|R4 Z-t#2,a7>\M2ǿl+d+ʒ^׎ʌ;3"RRh2H -%2}cJХm9"7:˔r)Vao(uJo/[k?\ɺ~u<<']7əK$7.3l"_r6qe{c?9wy`E^"EeHsHoDn᧚vR7cCL$Ѩu =(Nm/_$i,Lo\弿% @]O{h@ol"iʧ&ilq}w@HFw62rJwH??9E2hrYskJord唡d?U4w^D{&*uzEq#÷z.ߓ3 ә@nBq!VdZ<3>^ۀ܋X)iomc;it\cGCfƈgĿ|Vscy;1:3Nr#: %UEmxQ<\#[9wW%Q9Nmm/r"b\^ofW?ǭ-,ߓQ0:m2?K$h|jR@k`J:nDh唩qm'LȞv3 ɇkB h!uȫ\MX IysG3n8Y-/Df#3I}9xҵo%氌H2;95vBw=SIR92)!SD0LT ? rB9(yWA1S몓a)a>'{ĻVvRۓ]Vu'XOR٘l4seuWj*{mOɺnʒhW_f7g}ʎr ϧekR cݭ1T8yv\a|k\&f'cnDs/BQn1CkXWrk<$JY,v\kr&#Ū2}E 0衐[S/K,vl:r V+`.R}BDg=Biޗf Y'Jн܋?LEU=Xƻ5S-o"[YIIjy%:8!9U䇋Yh.2(32s|$!k| V㊶smw!+DoWA;r{W5U&)VkwhG|T~IY-{\SW;n(Uo/cmbLX!ǥ6\DBA_|2gNN1[w; -wj'M*dzEr|t2j {/%=Vn.k~6zy9k,CC,OqDvL"6HUXN'UR/Uų؛׸29+\)qSlsM ]c~o@=n+A(u%tuftcfRG{`mqpgsMgj#[[XV0Nvvd|ZlNutnv֚p%k mFWKұ6Ջa/Ouw6az;[gƩ%V ZzNz?6cUW39sBu3k}RꕊCVߊ]n~h:rVNR[cx E/;LZ=c;G#j?Nr 7dnW%]aةwalBn,?gJ:j1B<5A3u;QS-=Џ~ A,*f{UTKm~⟘؃;Ffs}#zZ]q+_ezao Yu3S\ vx'zLj25Z۶'1i@M;g%l?[J#{Ҵ8:ڄC~7@ cֻ/,%h %\My ,̑Ɏr&Xnl)|&.dR_m\$N1VjmC"y$E9 T]Fm#R~*:au2R엸tނm/-sɡ:M2Ix^/cf]GRȉJw89j.Uxlşzο _ Rad0,td~u[;G]m{.9묷Eڒ5IzRH%i.һ/ԽKh`猞)=,to9-sOnҾ&ajq*dL~uU-CI=2z^8lmJX ڨp=:}>:QQk7% s2+dxyHɏ RyV5MVx' b/So36×20v"桧s5]g.י T+Z=Z"dc-1_6wAŖHƠ=R qK˓io.V^)A 3}I̲1ScC1L'/1{ 3އRYX`fwdc}B?bmӗPNRgS{A 9_T]sdѹbkYz=TzSJxrm"ezw1O֌`i]6Vm8"k}o+_`=$|R&i>OQMrR:Za=lsy=)WF%)Qnm=M-% 5+?gc|̞|Yb=+ VK|7X"c)ă2, mY޸R,#;Pd,Y+ Lj21;7҈m.6IcwuXOD#2ڨ+~ >`#bwԇ}6[dH) [OGg|{?vhh^%G{lORB.2gBwGC}Z|rxt; hK})E(ltvRؗba|އ2U(~ڹK9̢pL,v)}ƭ`?]Aɺczˍt̓2tRށ dwx5ukX^mڬo/1k]2?:˨3:?76'f[͵ϟ{껮N*{L_d&﫦hף!DSTG;:grL0\s\Z{v*zƿ*o8;48.tvX|,m̸2?]Ѹ ]bNcVarzcYm[=/[="4GP$G})+qWFR@ sa2|~i@Ys1^>Aqb8tl\ɽ{_; )9iB{(8}Ŕ(FIqέsؑ82<3t#S=4Gj[q;N=g2hcdF$B*sncɶt4L&7zbe[L_=VXbL^]ʹ)uQG|sުy_ikYQ} ͺ[H/o Y }Lq|#BL{+d|4x(zزgC?hs7}Ua@f Cb0}yi>0aw1<8#9*qHM1c ;8Q.wta*o*;N+ o.ICP#sa~r&>9FN%[iZ9^5"sYNΜzObv^XY? KmۣhYK2G_s C|oc/Y(%EGQ-$v@lQI=[9Y3ƀU G:HKs- gXUlhlkՁ +)$PXc-n+DE6+iZQrBLʫC͍VIu6R܅ưU^*Zh Zv#-Va&Yn,aVk?ol ~4B0)!ScpjpMЎ U\0U8`wBJAKR&$"& 2ygPg Ri4/ثQM7Zi4is#K}sx:3`8Ml733L:I*f:3xdhVPܔHHi;,\ 3 l)_y$I@1ƈiDPkm|Lg/Oɮ' 6#t+i#d7i#vNf | 5<ĈŮzC* gtv׷#l"[P<-iz:|o~BVnQnWB h i)1vM]-\EC>]wtZ\%%5[[/Vv@3"# $M&eapî70D;ħi\CۮoEԲ #(qsQ47E~BMa[5P@.˼$_pWe;%"]kD㘅eqҎ%= _ ?K}qh8-gDG_7wd#n̏󆳧jҪ J?CbC(?ZTk ]p/EsRέ}DwN+wYfAUwaeHnmCtܮg 3iQ,W h^ξ?J.VOe cc /α7(QZ;܆hѮe;pacX1۱-JD 9FnXmQFjXQ(#Wg}ٌ^֩xAڭrݴ v݊_f> i!m!̈́K!ͮh53I"p-iwXGpN;Vq5^+?nAS(E0* ~ZWmr BA^k6hS VnN#ܮ*nc3.]Ep~m5MT}/-}/ou`BGݨ%}xJ.v:$(^ o$ᬖѬGgM_0b`OP®~UuGm>8E[ZocyՅgV}>ȿb0~-I8|LBſ-Or~ɶJ87(=/VЖ[!s}\?Է:}ަ7{[zozT: mǐ橑iTHy)~:+XٻSqGHaVgYNi!=ζΞlju8z`򖦍GC4H%Ytiz 7ًD={q~N?H/ݴ RPEJ0LZDQ(`KSz Rr*Fc E=TH*yG:!U}z35|ly0sWery1ٷj8[m#3aSL@c@4^?9-~s v`!V5""'bFWΐJ 9Z4tO9#r͙kb`\+8%DOT(R.p:@,9D εtf{/bQ5Uw87ѕ>.,>7t1 D{ m\^uc*MojjH=֧yTc*ZVk_*Ѭ'4nm qCUKX쎤 t ղ!ahܛa(7/^06YslVa^x8Gsp$c\׵*6!mfOIR)DD5/*A9)T pJ qJko/{p.*?E\d<8~X8k7`*Z9l#yT5> endobj 2992 0 obj [/DeviceN[/Cyan/Magenta/Black]/DeviceCMYK 2993 0 R 2994 0 R] endobj 2993 0 obj <>stream {0 exch } endstream endobj 2994 0 obj <> endobj 2995 0 obj <>stream Ht @ y9mvݰW,.x)xKU/!30a𤁚Ӆɮ+@Jt;u]:u4ǑY4`'ãvj 6b)sgC)#ZdH%.;`1-`u}СOR/ endstream endobj 2996 0 obj <>/ProcSet[/PDF/ImageC]/Properties<>/Shading<>/XObject<>>>/Subtype/Form>>stream HWˮ$9WpeZ @#  ݙ5s/a19vVVEPd:x^~ỏ &|&\RL_M9rS/W)Q[C5)vm_?^~|>m˱q&36O$L4|[FM^.|viKi܄l:c>$\Gmrbw@pM:c3\+Q[1');R $OTje0_9u K/q%K,RꄾxRsYpF+%bHا57xE}|2G|n)tE+()4`'^y°ȇ߿l_]/ïAR~?59,!IBc۰ (`-p@Aa2W @TGs88trnfdŁ6C1"te^˰/ݖO"nd,  LbkM6( ɦ+uv@ lᣣqU67ZBq9_ލӖwNG2w$vȠ m?3 >a1v'$Ϧ G-dfҚzpo&6#p^}r[^N'j͚0zېd8LC;{ANzޔ|r۝曫Iɽl b ':Ě]9ibiB?-K,~?2f+`H»52 ٌ7< X^ a2vT 'VGܗ-h2|6rq6mk,u r lkJ#yM4kO2y N+;TO$ Zk_CBkT993ECN1ORJu+2k3oΊ]w=mC[uB/3*ߗۚ8Vvfo`ny40*ms2ˡ'g ;k--`k &wMOi Um j=; ʝ/œœ8o/.n9I+o+of66ӕ6Oh36[g?X|?m)&7%) clʆȁrNզ52I* yU{VSr gC. H{Y$>8Q ){ !Z57okf_SmQE%WV5(d`]R5N9md $C'to>[Uk{PHv׈i\خA :yߗQB:Zc 8RdpI?A,"`u w\q8ހ*T^? %R `z[ƧdV#UUjs-azi>Oj1O<|''*5&6ϴ er(;@շ\pZL9%zer*q!lXl&}@ ^J'C9xsʚF{}O}mca wj*Y5[YF :)F@t8ϭ8=(2elR63<Ӷ9 _ ~,h'ŵ<bQG~L)h4ƀۑt|GQ@?f^~%ꄣV tmW^l'bG?@|t |~1϶3;֥P5|ƗYG6LcPdj*ᷕsa,qiҤ&d?ئfa eUK篊b2~@I[ }NhKw,~JZЇN~ n8W, h*ϥ@;g c)5O|1f"OoqوgdKo\8휻͏D\D VGGÖ]𑁏X$ȥ^=Kt/ Dþ/8i]OأhfdH9jBAf [4UaoVbi9ByJXy(%?6m {yJIL?iC ?< $k0IܣC ` T7M)z ȃ -4h"*M =`Y&e9t/\P 'WWLE̠a5u@5GJ oIS9 kb~(E)t~KuI7n7tp!Si p56>qY!]ܮv-|ޯm>M/ЍBSkkvʢxv%ٸkfRbS_&f3KXЬ?QUP<HLK, f #'%ѮI̚-8MbhjgDl/9}fTM>Z(K@%^W>#-Kky%E ĚߙCS5HCǵ(RvJ?͘<gXDQ|j̎!n$5E @yаlzU$ɍzE ˸\S9.`#*;ejiRF/F c /r poXmE vB/u@Ktot@~ME@JL++|UK%PJJB=%hLn AB*lY1Mʆs$EjF7v,h,cyd{^痴=8&+iQwG+e-[q{A\ʼ8DOLEZB#:i~Ū ]h|Ҿ!1LRqBOJ&"FӖFzj;\$ cV ZU|'J +ZKh #lj+́6'k2CwT'?iPb{І4SZ8(%3XwOtX?.`QK.KMYoMeP2:-77g4 uL%mՉuEŜjX'?4JtJّF^2|b{`<UO:Y_~,K\ bRa\ xs;lyqNNk;PY403/z$Я$ TH/n@:/Z;<{,& "weH@[# -eqAgLlx\rN Zn2D l[v*h ,tA $4XKVORg,Ra7f$ieC+*,7'Kf^ u>W dc1;&Ł#[%lɪ%l8Ee^\*`n2aeDat+$[(uk(2P4GɅ3G(^=`F0!h+;@ڜpdl'_ DWNn.HF$MJ% 3%>`WsmU,L O}GxJ-{KNA.~m@BexWaE3:Wgxí']^9T<LEaԉO;^ǯeWصIv(O#U<238RR8pv"FuaW8mS8CQh㌏H/\u8PIx)oīFůx3^vo7}.dx]NL3$}vkl]uז:ʊMoK)sEu̍1_JJ;[_f˜T)y΋;HΡU$>r݊kx(5QCYfoY"@T>.x %Zk\2wrl^8$4in|Yg"| td)-E  @] fI-Ɲ)d 3^u Ϊ1|u`3' jyy4szղLd!ˇڥ<$Tٗu(nmD0 'og#3 !,.T\qW} 0|@.>U}DUܠwc] +zGXb!m?1s>|B4efȔs;ae} 10փƈ>UFȔ³gnhϾFEkXH#-6r+N7rU$f{6!'|pSj1VA<%F.jY~1ȥ;hXLGz2X}(b%>;m7Fo%ٞ ݻeE&ra,z}y՛jF1=w96lke。͹ !ѽ#Y=É(cp&W̱da#kNy܅"ڬҲLUFhU)h8n7r 'B~8Iu&:5;\&Zc,e^ xs 9v:[cό#t r>Kuرii!&VwW}D],DOܵ# #3_N231;/bbVw1{Wټkټ|Q"gg79+"guc"gEΎM)g.g;rVv9+S֋mI͖Sr=լnjlj\llլ\!nfլt#+34KdEʩv '%ݵ.%F Ƙ7Kc-kdEdm2+\ԓsi:|߸da ꬲaԣ5sLc>+dVYl5CHŻ]g_P~樥wY/f2qvcIs9+/ w- ye9n7UBI@Vc(\.?u]`Xu^$r7%tAɱf/==vU@!NB7%d/%njk]*$OraFm=<= ]u]/ty@LWl w1H/}}} җc| /ǠC~F9^ƠǠfԝx"Px9 *(p쒦ym-=;]elR).ARsƩ@t(ZJ@sG}#{+(rl0Ȧ4%Vۿ]7lMU$0"y6̙t.aduP=oo~ i=jm`@yӮ+>@\WV8'i濌W9$9 }1.LUlzU'빬CF&[1:YdqCS'@wlGъe|#Ņ:v~r򢽬\i7Hhq+d\v`zӳ?VAG&6fdӮlUz{Ǚ"ro,Lܟ0ɞ˅9Uk.V BQV)%Uce- ɍP ɤDɫ If7Q(.NW-K8 -gHLӤ`VSnGhw(D]ϺҺ[k@ߖfoR^* l$̃p6=$ l9'^HUT)׶BFZ"Ҷe^|-Jt 9(K"f[Fu%Mb5/OUKaɷ#̦))ܻq?ܤXְ?rP4 Jo!*˶ȱ S$i+kVfiIR@e%ζِv_{&"W1Hf 8Q0=.̀π25Z^W{U!2ܽ6߁82곬p8rfsؚMoo6^ܮnw9=&R`o7J^<o W w-co2Gurb;MsOڟ`Ew1^9fWV4wЦ?V 4C@FkoAӃ YD9$pL}Txш@X#zK5 mm`S7m-쪝 Kkٖ` 5Yv#Ef;FȇnқDp> i=<qHdc NRʈ8^@?զh61Fβ̀Rh[ *yZ[50a@mY1a؞U{b~Xުe_dlVXP+mvq;Dfh5ȱ׸~3I76 Jw@z=!ºLq>%fi.WQoMBKu8ҭ#-)Ѷ"?8}1`y/g;$7 xbFzv/>WweSȮኳ/8m˅IN_싃F/P1 ƾ9{`8ٖF*- jnY7ңxM-㕷0Uyޭ KS94 LlJB(@WmU@݂)π 7yd  Ҷz:g+`*I[`#`zۯ Ez4*23"FS CL5} Q blBIc^^0iMhtl-b!@ @^, ,GV"`b):9=ϬQ5Y`NFځ[Pԓ-KLa%Y1{3П.S~TnCT堉q\EqTo]Ӗ/P-h Dbv^lKY\*{dnAr꧲}̖Dnr)&NE} /|S=eJJÛ̲r1%]8:0)=оzwUqvdI(U:9FtZMVv{( (Ygzi=fˎ de]=̓%Y?]I6gbi#|CPߌm4UWӪ)TLu3fVt{ӆM x1MeQN8 CKT`376*JDfe@APk] 52bDc3F!rkʜ; ?ǐAp? WbrmaKxQL>yMRJ;,`Ha!5cHޥ|á OҔ漏dH3  Aj!Я- jtٲxu+q %=](OAeՒ=Ye+JE6!/T+s']nlF@X #󢺥- Jɦbyei͓Pj(w%8b`W.3'K!H_vPAu^*4*MKF$5M`,+<+'Zf"ƥqqz/֬tL4cuջ0аq/26ٵ&!҃W`B0jQK tbQiE]82/qVCf;bnZ_QoYS:7iAΚL%GHF?A>Rt ޮ]ƵdH>S}/I.Q2J`Vn͢a~HG7'm&ӡޠ FmyPnF<\Fa2|^p34Nũw3j{jZ֞ų[cdi58n~7 nÂz/vFn.S7zP[@J`6.6'qUO첂A]~6}OŒѕ:eRm}bbG{'>:k_m`<`G}6d!s FUG9>ϑE~],9s@FGQRjwZW9G)=T=PD2)E,j)vt5ZRSz+ <ѭߢ|jױ,)= y A ODFfչ#!q 5v"bkm;"NҎJ CD}g"//Acg"%K'BpP)'ᾫi-TNE` wMq۷]uVU $=:vrő@;CiG/܉3 ?9-^X~ :n=hYrXY 5qluIy F7V3gwAGxkjɞ|VI޽_ <[Ixnv6ʼoG@tՊVe /-:Mia2jEe[ A?שkIǟ?>8%-7\/ypX/}yr/7٠l|<¿Dx|  }|0q{MϚp3+*Ic/h!3]ed_%y~mvCگ:_pG_n~g{//7@9YXWIvަFC H/3 M-ԙ B_/ 8§/'u8Q/rGEB!(nsŏ7ϕ=oϏiP1w5O]a: ( |{oג8#Sc߹~ sYQ 3n/2[#I!Xْ,89S neXZzev#W+ܘwAwGX53l.5 dpc37, f_jdG&qqL^Aۚ땺lO܁^0( ,14Z FQA +SN!10;,[yt…&*rs2.Y\V la%)8SֹHSscbB )VlahVXRT7݀TdC 9qܸٳ&#@ȹc)-E-'=՜&mʦ>2AŶ*6fCUJXe(gpf@C Әq%w1F\ct7X~z}LEWk#ASN;6f|>@˅FJ?wmVou(p C22c;s/p?c07ـ+u[hjP'CD)r-NvO;vGW+ɑ!kd9Zjc"ǮI&8ע.Mg&vcSK 5Yo6-yz kj]#7Czͣd=G\-bsE+HrS')QOLYQXiLnY"U ECZʟٕ-EœT$3捪qB4d2rVKTUanjP~/`wyO!{^*u;%BjUEDh*Hb]fJՑyZiF+0WWY?{ǵYEe8+ѻmMjn)):Yb|BlzJDpZ.YP9o՛@Y=B9X掞s.8mZ3oQYuF_ t%9:pfB8X57*XNh`Ȅ=:j<+hH$%쬾W`2X]nYf8ڲnl\Zv9tۀOm!00ݬԕa(d(@(|=P噝XE8Jr ́("(qL %. /4PVinS6zsB %ΪPʳiMBf0Ǩ $: p9JW fhoWQz mQJp"N9ʁ(vpIp>Kpe'HIE9 x+BkȓOjA) 3nASR<6SL=r&Be%契ɒy 5h<S޾SbXh̠)ꇦP ;0xWrZ XMќ}w35GnӔRE.^> }` ~\ݿ9 hzxl}V*\FTl =M&=}+V8ؘ[L5Op;FXc RilИWMte]er\0Đ ef`C7?AGF7F `¥~%:br8.}[ {M'}|±^_`?c<& 1ª_dE4W]. .u/Z1բQE2nU^&ơYbͫ>}>s} >CFSFէV}TZT^%9FT9 zBAT}@@@uXtbn~!rB|s~26E>Pefha:ϫz1RVݴ_OO|}b08OZ3;z?p&FNJx2~6Y)y1?f~tD_@z/b꽠S}{9$9k~ŧxixks@7p-ONx΂[7Qr' 9nVyv4<1- GeRY~86/^D*0ab{6H UKLUr@W/1 g⅑@.-f % ,*뻚22q{i?@]BBAJ@E#\ wl❛rn-YRmRR3?,-k umߌ е-TXD#q)B|&F}o8QEt&ha+l(9H )K>: fE x5X&7qm(XICrٯ2]e  &x+&@e6=5j@8 C&%~îg@wL)(iMj(.Лe`bH׳Ѯ7%YA_k_StQ)!& onh",DLb,nʀeI)(_S ]͎UM$wrr#Xn!mjY̋Z.15&"!%8e5&Zvag%/G'δhOPz.jgCTLqWy(wDiLznJhdKdRmji a9+3뇇dM't=Or1[DG!Vӽu/ZYN}3#y[Ik+f(ÏGLWKOQ,G`H>FZAŠfAk{ہXq~`.oTB++$osH/.A+=W~:+t71g[0\PJt Ҍ.I\8ʴ<,'AD2>UZsʇFpHg'oi[!T/ r[#afAܰWh^ _~[x?=3_\ gD9|JKc `c'lM$'7ǛJ!sXVhF}"UǍRLIs=oNܹeY)Ƙ~Id3#2H Ͼ~FokHfU3rB1iYoU+q+L-PA` nnR)+ȏ~~؜Lյ /'Ll>9 3N~#i=2Du MiߤTn}?yض?osɳ!<4Ow6! )1!slŸu$p\s#eS eo`URNZlheTTf:u Mr\QĚ+ȯ+,e(4ahY@JP_mhS0bnλ~Yɂ@PG~DFk296 ttʂ- )Pȝ Ssڀ=6!8M;FQ=ްw!E=tRs+@TN(P)RVjl~n5Va##DՌ;s܈VDt6 rmSbP -Ѧ~>jo0 96 aѷ*:%(5iRBZdGlkJ.Bi3N)i AF^%A-`˽SB&.y"ZT^O;u ^qW"oɴ" zw-ϥjn.Ox (Ag0@{|n-lYbVTѧ~"!YtBSB<,/OdSQJi6#QD s=yF7/sh5'IZGLz$åUiԄehh-,.aA6_ǡ"k`khaIԩDZ7:q!SYS~oxSo0BwMuhP; E%ZH}`;fq|laGdUu$C,,pѤ+3#01D^eAܘ(h/H"aġ+&Y#P-BԽ~e&)-G\oܥN#ɏzހȌdqXAY"T䣆\OJ!ƫ]W_2Q?y?Q`)_4*y}éyxm 1iIJP5>>QxP{„\,Y WZ2FQ&srB3LR^eĚ `)_#EG' 4[>]RR~2/G?5ׂ.$MW݁~4,Yy8S}TDR;Q9_3?KX ;0LM'Ldl,X[yaھw&y}c3%˦^xRnKH@SZ&)kpXɹzl FKӼw%& UE1}A^biC9k^CA+$Apk=kdL@vtciNzi:'p42M!RD۱BhN~V: ;$qZs]2]a$IDWY[r_#BА\BL1bMcfgڙ)( ʄbu݅PJis/͘#2@xkkhH f@v,![ gn^Nqp UYElTDs#9RlY N("_"I} >_ e_x]+ :9+j.)ʚu_as=%+RGwMJڮYwQI3WK L ʮ?؉tQ7 Ls󆶵*4 KFjטusizk*N8cϘqd9cF9$߀?# ]b`έ~neqk Ƶ%?L%ʟaW e5\~imHU,SѬ)LwQ,Q_v_Ϣ+xV:N@\TލḠ$hp&_+p~QM'f]ʢan4RBU`W2 R@$ hyacȤR! Pz)|\ 4kPX^29LD!*ξ!~ ߽AFeQOW-Q$q:F}IU֦Ӎ- 5r ]B|\O=,„j1y-N[ 5t7}5+U݊CAժ\!f bOȏ_^iHˍή]z6`4/r,Q!Inu!~&h-X:%J:LsM'&b'"Z.5= L(a#-3/|bId`V=W5 xb/.*l VpI38b}w{e_883> ̔NE\IuHtyK[5,HΑO3Ž}\H,\֯Xwnv'v۝m"vV[~jPߦv+eZ@1>RCV朹2 6t׼4W ɤVp3 tRGnP_{ ],^vq9Fkts^hud鯚ϽaF3jbw5֊j1KQ޺he7{`[v{6}xg U%<):CVJ%xX.軉W#afԝ!{  :7(G,eq(X_h8LKiuČ.{[ _L5ZSẔS(X9<6!G^5Ċf|iF3|@שY(Naf j0pxL8_@kbuP>lmg ,K@6-38,㖈=eIWx`UR6n^}n񊯛cMZj+dc8>p6?m:?pLg'!|NErqOEPbN 6_ßўEM̞zّ ՜ϩrFuΚ+o`s 3Zt8W,2PY'XPsf/rϗT(_K&@ئ\!^JmQɢLEv釗?pM59!At(:xLlH$\>o+VJJ3X;x܄Y$2WceBz^^ؔ J-^6[WK% )y30pD|0ۀ7UO0hx<bV΋Xh]UÌޓx1C2m F4 b wV߸%:yXɔs"7C4&$ 7Yn?$'n0ܒ}TDE ޟ|/UI2m$՚0/ bg4Y&5pidżs\'lJNe%]bb??x \rxk[\VPo!2be'% ; re)-Tǒvl[dު;i22Z6[wf]:G)>ͯ/,,~/lEika{Ui&PSa纃L :6<3O6ҽ}KFe c|ؘ~q3@C2PG2]5\a4&E}#R6&H")l8¥$΅V钟r*49X^4ߦH%6#o:,a>4៸83ڊ^8AS(^ZSX0\kLt5Z{yDV 7IR;=U8_ù] nj0;{ [-BH>99J`)u+8-[?{J'77㪰ƥ ?P}_P}Bk/"T-B_D*`2].QBŵƿ"YP6妪+ %>* v6~3IG:InQB4\wIC^Υ9`tx颶K"1f3 9ޏ: *޴iU:yz˓lLopx8ͪxUFy ܼhP()RT$g2mTE{WXH~i\ת.xXR[PEAMFLO3*nB-1fyZ̵nHQoN}<"msnJr~%NZ۷4T6mA4-yZ g;(~H JAYVnd,T4&%g!9j>ݪ^ TJ\:RCiZ@螬n&kIF!ń8 +t$+r״͂}NB$7[Ί;Efe"]-fsLMRR>dKv&W R)"pյamnٿ+UʲweT.\ڀ7Dg]%"Oo-fKH[iix$rvI#r,%gMμA | dhaX!4NYރ&g{T4LHmô84&axe総Yv\YvYvYv߲, s=0j!wg"DWN"l%$XycO:rWa ;gx4)2 (^/75Z%^/\M!zߏ}%{ܓF,Gz0p)bUm[fFGOg|ȟ?AC%P^tCQSL^2}o?p$pn]s&@A)vOgmЅ,Cx;oc\~IxE_"ZpYHj\3Vv/w"tGTiJNIܐ̸f9Zؾ=߼WK% )&w-fP _ߙ gFH𦣲YH ~ η(yYdg0muFýjDz7MQ#I;>{}~o򌟵F}?^-زepe/WڥMi;qߠiBl5ݘrC<#0Tx-;@'.5EJu ܤ'Y Y"* w~Ǝ|Tc3~uĴi\\e=!Yq{k][t^B+}٬~Z}u^JMOӮYڝ=FhW5mk(v,QE`K)kv=Us 9l@teBllմF'"xs\$# z1`wL>~ˎkŁ{0RCi<-XFa0փ怊[BCvSҬ?'N6 KO&CD|p4[4WRf8ĸE>Ș}D\ǵI*="woKkEMR aqJ]=b้b4:*E {('xZM9ݢb5 ʛXnj\Cc ^EO@ކ0pYg%|sa WEƾ<} G 7HeoWd[E`Pƃ!{x-"IawNF |/2\yʦp0GCrȆ-mɹf/6$nk$cٶlğ/ ϓ4Z>Srdzf5r49 6*8jک+GET*S@[S&,/9|nPQq1^UBT.9%GLe$/VڀUmqpV*cSuVբ1b>qZٕ/"暧NA&_9466(9̆줻R@'C;;+YT }\ EҾzTgS86 GRW;:Cr!e8O *d h l-/0LDW"._{N+#pd^A`YH g(CIuY"m-ToU}Fɞc@( __iAi/p6놈M,>U=׍ *Sp EB`GݲdE׶Ec{3c3V<z¦ƙ \UvgqVahbruID X*Q6QX\J3^sWry?O7NH)b#`HgW0c 5hR #%;#9NSVmA<ہLQf`U^E7p kU4x%^T=-!aX|>u1!QICpD lqAΕF gyͦ)z-i*,т),]b2ts7z!I!YGLhs]_g L/ڜp!yl3CZ%SVܠxaQ`)= OZOFioڙt2 d9~PǵPJ_A4p%חNF6r@ d0~@30( q׭1;u5BBgE]Ywp%EAq g ٪L_1MP0`(q.Owd\2 ˍ^/,gx^ǼqbT:wG]sol,`v-Jxvaϐٙ#?.(Mg1mpǁ֣47z5VOՒ][¦R,Sw$>yh1 &A\$S!.AnJRSOOHٹEn8n'8rcCۏ#7T9ɑNt $HSE%ilɏ9rP-PKt~G BgDK>xN$e$A *$HSZ䞸MO| [v1$EVEƇHºmcNᛤH%,x#x0\I[W2&-8w (ɑpM4Hp#Z[85!}G]2Ձ2LR0iؚZ`3gZ$0Nu+x<t2`@&k/ߖm_:ǚSF54!{~q[jp]jJo-*Ƈִ݇zI^`ݩ8 B6mΎ#Z<40v$eQl~kA] FG_߄}3XW΢mPIxowKE K Z1Ǝb J!k h׌O~f|T~?ntm.)Gׇ,o̜n2 Wރ}QT0 wQyy,CTqBtT{sv7v3lvs1:9V߸CF>y1D*IX]`f=HtJ):@Q hǂ΢GӵXnlLy@nS=[4goTrh+ɎکHEléPzu#3iQJw^gX4#82|(c~7=G{@lM=ɷu I ‚I.5zsGW+j7?McI[=͘JPl -Dhakoá߮y8.YU1m)^Vp??n6jrZCXޚZ:XMN,(·E,zS1Зkιbg{} ZZϕ2/W&2A8ב E.a~1\wUL+YF&7 ^~)GAؐDGNV{ď.K}OKRjK9L{7EFB Dyb cK"];~.D~WUdw=ړ/;HW+PfR~v/l'Ɔ%Vb* sSw|R7\IVl*rcAgT:y_Ώ+u46?,|⮝w^SճkT[bkZ}x"K`َY^o2xyL^[pLZwWYG Ț{{\tcUU٠XNmx:MӒ GBm{,ht[e}Cu5>q-55=4>H:SAEhOCo*`TKoV\'L5uWdz\c}ѕT4\_Og͒"_\3D>6og4g+i֮> T,YWV (~ް繶j |j )ufoM|| ?yՃxb8=Mj c&ӧ \K)ѤmF‡ GTA I?M,DCՃc 8D`qM4\>M*Xoe&A>4Fdf 4`P>L0p,AŒCN殺wBAAYS,2.k8%>yC(YZZkRR{YT!yJ|(aBc k 1GԌOIQW. hv,b_zdL _ԆGƊqy(^?po$-Gt*Q2Xa߫嵒9+D1v+F896)q]$cEhRʢ leהl}eYriPōŹŖ@jLӫOqH酹 G*9nZۻ.VW@U.ޠX^51 h #yNQf,-[Ul!ތ٪[w۷lr"uQ㲬\GwݭGz^wLgWs;`5n۝^g;q\lu厡خV6U0`XOO ~:%.cd[!6x:QԸl̍qI t1q#@lQjx&յp|_N_7` ۾%T 5)u~b+K.iQfxG4֟U|[3'dƞk?XL;A6 ե⊛'QaxIqʽ߯chϨKhS.:'&<} 汇i%!%8opFrkւsTh'̒&kjl|C*rriT#+xQprY j]۴PZ`Z5]i_d4 yV=ul,"ħ#֫i^f)L8RR:V+wr/Rbʌ MHce ԓ/CkOĮƁZ*PoLV2fOS-ITAmƏFԁC݃%s-Q_,l&E/ƒR,.Q#dGB]pR;dcڭ &vcr k4u8|q5Ͻ#Ka9|Jf2I~'$ ߹c2I8Ld S-t2px#dJG00\Cm} _S> vǬ8D(N<,"##¹(::u1o&7QgP#URbs- I4dN(͎}snByH^T;H䍈KN1p+ ¬pKf_,7 |Cۘz+D"l] ܯgI=2Ji3M\)+㫔T׌鑩(ʞɼT#x\WxfXmN m@s'8rYYOSV"$Dk}[F ұSiI&dһTtvդR7Y8 C=#Ш@_|eݾ7~1 ? 7Fr6~ llؽ P4v/h2-a_a͏ \ n~!k96'>Mllʩ hkNy$X|˩s=%XUeFW2!:kL?CU$Po{I[%~jҲNDRoř: bTq?y6 p5/*}ܩ&}L\rN2686E9ݤwvGS;3XX ‰kݿ؏a>:S%FW@>TrEcKۅ>%wPrbI|d^419g2՘}P/5 Tu{(Kڮ"M 025Rc-QփSŊ!-fQ'i?zvNM#[ĝ rb5e\Q˨/3r񙡙 NֵHj@"Qc{2TE1U}?7L\@6z^zmHD^|I$@kW̐dc6RnRH9T 'q{ /2 BWNa)g:#FOz p%44%[3.&/RZƀx W6gh츸rc"p =یe)6]@RdߤPD,|}ϼⰪGqgQ0/ԽYwv&sY VٲT! B2 ioui` VH?9o %Nt|.m}-N(kj5[![9&g쯳Uw1:$\6KpEjꢛ8ٵ`4/6W '4/Qrj1}R"02 xhY*nԺvRB7Sk[Q@،q1Xԣ$4;ut{0t5hvUwe@6@VWW< mMg!od/}g$+52VVz}U; $C\d5Sv}B`++67F N Zc7ѐ^J4l@/AϤ,x绫v3/{uS?0 "N4,g@XQUd WGZ_w _N^b&]0W|bh- ]-98lS=1 ~ܝئR!52 5LfimM( ⦪羂k(A1 mȷS`ގm"+[_dq5bڶ9WHvx֋f LXL-/n%j~=*J&?Gʜ"}}4qGȘ3Xѵ8\6̄1H#h#~?^\MZVt$؋z B[<(PnH4~mauޫ9ĊshĕVR%1ۺ'c=lzLB+7'3pzXq0yoz#z:jiq7OE g~2 x_a1;ƭE9 Г>)'?(O*Z]Wq> oGzd%[A:8x쬎Js>I}}P =2Q6n+)64aQ=9!G1nW}(uI#g]pc«VӐcUgIT ]EO UbtBbGmi:S+QR)X/Zj&Vjt (M5qpOtRVM(VS'y#4|_72 ^ O臙+=؃ *m)yKfwD4 [z"t7<峸tesBi֏rHhI"#+QwX˝N:@C+$IH@'+ӤჅ\aCRNE.w3itCfL<Ql84h/(?Y>h6*7֝ hWsahdN{k=_'~GO7Ξmꊳ[]EҘ){7VB CT޶hCV?M,v^u kM6=jOdHnxf0agGP9ECz:,)oBIl[<5PڦT lWhEr#V?">+{2ULI?ybኼ;HNhTo!^=F.׮&.Siª@s\92'=R7&bsjL1Ƅ6va"7_aGW-:{ez). ޼W. ){EшAOP|?yg~&Ӝ~!ߌ`߯^/r莿?;06)>&PUPĭ>G~%'_`4? J)ѽD-DQ%@FS(öiX`'"0^YrNnbEW4J&g=K҂C5GÕ!̶AX2B1nTBL(gjaj6㈩*ϪϏ\(Y wST2v C{G4s}x}["E"H1|(P:GáTD}prr5 ^@ ltyh_^_~<徭9كRuz~}!!D6WnIY<;ݯly!m֌zܟjTS(t&O⫉iP o0>3NK/4+IJk:Y[@|hŧ(o~^zuY\~T8 BٌڀkdO-N*G?D5I:ƻXH7gˍ>aO)v2w4I%mj>3i)^]Oч@dx;u?XM:.$F"T/kߗ b~{<"d@j_/Flt RGEلsjmSW\16e;4ǹ; =%bnm;T^#ʹv01 qi`=)6!ޣz[C+}(?2".To(qR?/N:KLDSA(h,fo^تbKLC,N>X̝Ɩ!j2B0T0噀x3NwWxs?x6(1q]*@P3sO2+ vاF;~mh(+7!2PmS0IVw"Tрse&(h_Ԩ2Սkp3܃ÀcY]gQLKNYq!׋*FcwP<)>;B6>C@T~2hӦBkHFVC)`~6Լ$`6mpT$V!?"YM"E|>fy9킛/N_D2$xG496Bl`멕0|%q^0V DFlSU79?'^Z첲R ~hX[o]pǻ~8u]/mbpCSMS}].O GX;dgi+8 nV Z=tV aU!BqϹ~~[@o34nZ"a?ڎo|9m=-7D C JmMr'DrBH0[@ote(W͡VRi 2cc5pKi8Xqjt/m1e_Ps'䎢0"jڵ#o>}%&`ѯ̹2>8)pZO a}1 _]\kl7lNRZSEJ 눓0) սOՔ@Ipg~=z";3A_V(vH}qMk'GIɱ&{n+*B-*Ɛm;b?MZt`m)!e_4Q+2ZMq$wQ>r>kxw @nZ wbwײT9Vgϵ%mwׂ]xv,Z`s??~(՗>ʙ_W2劧 ct}Z40&d:A<> Z(?xo`4Tp\kXwAu~ɒ[;JMp/Z ahA6¥Yc3B:{S!?8r.nŧ25Pv-ɲbƂdrƔvp"@7/L)# 1Q vM|37C0XDJs{\N 4ȼxJC#(v(MRCjv@?tsu-=4OÑN`џx<kwn{?Mv}Kc8ML.ͯ@ftr쥱3)LMgS@V m:!BXCc?bPxn(*ĉrPurLa`a>曪|l\:.=!H֞20OiO!$ڸW&`b{Ώhakk;բ6 ͎}PIJVXݻ4gqh׺8zvu,䲙#'\%quYalzF00X+IIyp%f.1jI;!ȹnRrꜬNoVF2ktKbfݐm ̞ZsisOҝ!b+*$|ZɱqhxJfV@l;v%pyg=;Kc;o4hTSi2PQs{ucqV2]kߺ9dLV.GY]>^Ǻ5>}bo(Tƴ/R8w,^tH{m- z(ûxq'fj!5˺nz4VDS;Iѽ>Y3KN³Xtc ~wafiCT']sg7^?7BNIQ<RpsJh?EF?^z򆵝9NPnڟIf!>w! ebD trpW?fL U37[xŠG !{ VmӨ b뾦y}n8x,7U'a#?&D;Rޣv*4[B"3I]lR-BWYWڒi8=UC)of}A51 L7|wz`o;S=q >]9+Έso$':O<өYO<_M2J{1AuLgg/%_h '}^lO㲧>.{21.߫Nrc2u#CُͦϩղLw`i"m+ Pwpl(JZChȚn/9isK7 ڿ48h58_)4<~)u k5yϐNj(#W;H2%g^y&X[ A+:C JOD@rc)@ېINdȭFK4H…9`L#k#~<{M\ MITQA(moyTϚ9Il0c\â1'X2Xk:5XMS(aEyxɾz$F;Vw|G v9Bt.Of;FJWyE|𰬳#e,= 4޴p|EiwӍ&z+deuPmBb5\l퍦$1ch7)bi͗m! Adz{ua:b(oIp"R*.P|lxɺ Uc$!51s_0颋X׾s ƘV؟%غ d=IyC#vӺa7>w+m Mw\uXkp 1M!Jxv#N˨WȖwY~[F^T'Zr+aާ21rA,ErE#mȼU,ɆjVb`\:\b{Bkiou"}I{+sP){laB)<}cHKy~{3"1R^gzXԓ5 7tl{1ZLIZ}߃fA<շ*z^ːDtWg !y^{7SXCD4"wSk8ISt:R (t"S}:cOB8 JUu1NrAˇbH^c2y3ITܺ|P(k'hpޓ^#"αlź%뭥*34$ϱ2|=ff<|qW6^6F~[vB@OqKQ5 ϽQq4?p]|k胒 &P$@ ?u YHFgEn|;!'Ôvդ~#y;@Oj?f7X=;'QF(f.5eT16ɕ voQ9Aqj#!!3Ұ*fP^.V?'8\J3G<ќ؛q4_&A$6.;,?ޚ>R u(hKb): s^4PGaނ;M 6BW(>5yufOry-Ѥ Ix@yN :ɥ WPM9R;eh?EŠ5Uv:!fg#3Ë5Za*;lxGRC Jr3Ýtp3**2-?LBoeYe8Sd:Zh]րp5mmg,4ˆg].B| ^.,K+TӷPȈ墶Q<~MBa}vV: ] 084h+M5b } 6&LWb]yl)cM2OSxm Oa$k!Ľx[Nuqo5j,v7A.\RsEgRYuƂx,` Jŷ3aZ|d0+H# ecE~&_VTͦB֊Epc+ɳwW7&rL)8a\poвVmAI_h^^[6kWT;*͟ a\aw0M*.p@k(2ْVɇ|E3-NDL2=7%=A"u\βPoIKUwj 24\U@BЭomJOV6/ƦuMqphs.44Tw_ٔ>lډ{&b1f{nhѱvNr2ShŐ#.FV/hV.e{vC2ۓu;⿿^+\zرB]ơ*@o=Piƭ O2o=T@@ӚgI X 渔 `6HJ:}݂t?AŽhR/5[îTİ3S.UFy=AoEy+܊"nA]C4O?^o}O%ƒA+OA.mqԧ q8U_|P \dD< 8a 2F\J\I),ڴ [C)6C]/}kp T{:' m<]p[`Un0GUCBxL+mVC85'M/.oE&tD&[͂|=@JSkˉ/j9'vT 5rQ[ɮ:v](2EΝ#UbD*A<7LE74mOM+ZpuʓpQbR-V{x@54]_E*+!H HDDx2ʻQ쌕)D/Cl FmB@i[E6~K83.umQ)oSAd&? 9hmZ )SIY'PL,"uJctiO4\N4xPҧ>ҏ'tɈάժ&}3nWW3Vu:o ȅFbZ[⍰[͛1םA.'?gyK<ۊv!vm &}~x lf6F!8êN\%;QHgz꽽(5n4I꡷ro^J37$9 $^ҝmWW*bqzpA|Ƴu:6wGRX1У.B\<0,/Mi`'_]MЍHY_Ve!5tU K7>n!3Q*I|a)\Uy, 7"ݧ{*k펇[ WgYe\|= vՖ;ˉ*'Jk\빲Z=g44kwWB,UPw?X`p.Wk UOմD:þ"l GCMm'ʚgo|[oT0EY&5劷ȋJ*BwZN9olTxű?hjP܄&m|Y!-^Gh/t很gM&dK[aiZ-U5w|  %)U.kn%·kt.秹U\vvOUp+֫2Oht9xyhڪ \o(DB7 ;yu} rv[.@x@]WV ǀTx0avN 2oKٮ%( 0yO~ȍ'V-Tl@Υ?AܗﴫiD6q8@MYMzx1u3Ŷ؅uhU7lV3ңLp"Lmop׳X7|Ϧ *O\"n J!6{Hd zOcJ׫k&o8Tzs "Ŷg)KsttmdMT^ ZuE^rl[TXK}Nâ)!~[A恤&cg 3lMa dO]l"LY9M$/U䢆{v/?-CКh2/%$Olק q;OfKe45l& fY9[pjuQL&)LDz\oXuMBo&_f!d_"GTYM]<看*93dk|uY{p.⼏9g扴KѪh79x#^|)4DЖ/6_ۆ㸨fYB‹)a_ƒT yiRpO)ϧ3) 4e<RmH@5O-G))ܳu|K꘷nn)\|K۸vzk!ͧ6}{jֱS z!1` O5$'[ )|!eo1{S i!|ˢлCWa?Ŏ:vcS!Y"j0Ot8o ؄ o,SqC N%{t&EZT*|xL{Ar.F;j^Kgǐf.SynY'))tF,m=n g8Lt0qЊ9uEVn$oyn>C ~|uҧbƆ@h4k'咣ŚƉ[r]d pq)Uܳ,ϓ.`vKK ,6e/ziʤA?'somc0 m9t @0&#[\H)KF؋"ET_3P1DU'[_2M}#q,'r0xj){̰m!2$#OI|\΋7LB,]|)w]T2 Zӫ q/\A3Z?CEDrTE/7@ˆ`թq"dbZr)@#;ԉYlVaUl#bD;KWYM{#wA#Wu@>O ~%s`DR^=P"K"W\O^?W/>#Sו3 d.IWpPY‚*+1՚ʌۀvx*Y~<šNw̾2U?7fZD?.*Z;O65e6Vܪ8qZqiKs uQG;Ѫ[ w)a@e߱h&E?$"EQ*u\=E_D]p^hj7谦nl6RE+0祊%r N]nA<4S&9'"Va-o1\'Rm@ք"A)cA]1jmivQ/-:|e3;,99w@E5>윋\&;qז3T&]X!P K[&\| #h̋*}Ӫ+qvux@1FJfO*PNRzNVaJ!C'x&lchf*ZN &Q$L,qaQUue2R'gu%<75n)V3(S!?rr.sr0(_\-a~jixXAN~#[ᬟ8@M) "gjWoEz+X-hg>Rc8{1O=Y,6\.{ L[] P65L₠[~s~w<1v^rZԷ$ Cy\FX:anum Yh =Ʊ;:>d pgyQća~kUrC0l25=ϞȒe:Ahq15/.\H6^d5s;Qwbpv ^n+W(w<.NylXU֧X=3 bXREQ0UN8[Y\0NgKSt/]bf5ņxr>UU~vrj܄W?v sQzS pFA نs忌X?Ȑd|7 +]D<ՉS: `,5$u6D9mWd?y8x^rhZAAFN󾳖.pO٭e1Z%* 7}ުzel1-Ϩ%%݈'~>H֞Hmg,0jWsf5;!I+T׆WaǪ=6'aYr gpq '^Hp=栋~1Q`{xѝZDijXk>dևLIBm٦HK:; !E ]"AhvxmS!mܶW?ܶwhiT4}Ɲ:O) QmK6:8\Ճn֣_%'unrXRIN;̵>uOw8R?Զs6l۰xOa1hٹᶎ[֑vZloܴj^co݅vuggcdyw2T>a'gsD%̏o{0î'{D%j5xk.H`ld<_,ṉyT? ƍ,A3˼ d;p dG:Bc@2Ce 1KsqO'ws,D\ 8փ$C{V?>*.A{ѿ>JXK P5s:DAa]%  ^c*?KΪn`*sHnffbrKqp"*%C[N[ ?_JP^;wWP&W[;zqzњ}&A'v$LmD.g x\&科rCC2d:y6|)7dr=qQ;+:ФTG9dF飶!tHYnF7juHh"|GfjQܻH/ҢHoj`<H m܌F ˯)GHIFrBQU|)wk#)y=}WQNtGş飰7; L/$槏ٮvu{^-O.czS7y? c4E~>S2SbS ]+(ۉu Tl)jBj:b(S^o3?!3EM`UO /S4G V#NOL~#V?}$pܞ)?]º/ 7/mmaXk4i@*B'h%fA4;aqa `q=mE8"q!m!q,ߺà4K~8xC 2 T?Mɇ{};;qDMJ}9S|Q3 x"rz!r sir~CXP9&W689&gΥIW7RB5J*7J72X6[د  ?~ཟq̿`̺rսYwψ%zBG'158m(UIzge8m Y{9D8gG>tz r=4FSEcBbN{qupSW!/`.e#۲W$lSN'Dkl?޶E1›RHqt(PL{X/ }.ة]x'Ñ܁SMC]lÍx#lxQu#h22;'=Ldžנ`+Gokp潀MϩP6&+yBot 2jUo ӧlGT yYՙgs`2`Q5Ȏ:>:ng9لXAa̋Z6MV^М^Bh"xaoO a,T,fYK6lpZog^ >ܵOtѶb1;ьr\~>/h<Ȅeb+m3ΧaBci/LI_O1g'Z{BƕnR9Pn|/{i#` .!&sX'8piX`~r~m۫Ö uȥίkTÜ %UK RQ#ֲdKٳoә_z8B'_H(Ar>x(.d9P{:tB麗OᕬGHu 0 =MF'i2]O0C5?s.zʥ R[ @NUX!>1`L]bs!r6rz#; ^>aKr!\J"\xŭ" QpʾIHeKS6j[S٠{C7"h\ c5 WpT՗_^nБHJlMy7Rv6yc?' sQQU;9o-!M8./4NeB xH뮬0 ʺ]W]BeW^wQ2rISQ]S.(tMT &%NpmL%K a(#* # Qv:GeQVvR";DP|]AP:ɿ5EQ>p&z:F];tFF=CAw݀ܕ:m eˬq{b ,kA# '7׆'G99_23):*opoK)7T\&):UXh1օ9:OB`i `15[P/7ՍSe҈F:<+€5^eĴ6규a u(Cl4N,r0@& `j@'͸dS T&ĻS; "yD(̤]3d3+|dh+ vV?pR5h5IHŽPw۳ 沭iTI:IJ+&[pYcՍ|O㩘'teO|c0ɮrvs_@R{:q5pˆ[mm9zMOHkِ^qeѤT90sx/[;1~,QB uo*byDS̀FI"n4:2o e=rxu_dl~0ҚX+eWݛ ө*M҃na?Vä7stéSJ=O|28Oy~Pc{lR rD-ER̓ɨ@Յ)©鎤jT/}A} 0I5MQ7|%-$UYR^@IΩkTm:ҫRa:n?X'oƑɛ;+jE$H/5(eTރQ{v!J0*~0*Oo;j[% TpPi]|JZ)lɧyJK>5N=)mɧ6{. \Lt0G=pScAl)`=̤StJk)7MO>ٔɦWlz.)&&˥Zdނ'FpK>7?xiä5TB*K,ޓLtIԐL&f雽_XtEVxEii/Cc$՞ Kp/pȉek%ZQq&ɵ~!+EL[|ݐ0tk9qr"d7 n qRE/%z~w,7dAua{ "L1?j~ K7|^in֛8K6O/;,\s剥߁ifq1=H~5j^є~]aSyo,b2ZBrxEg|>K{H8&֏W3~QS@1fU$X^?s?LGW6v";"woDyAHHؿF sI^M2wpS խpL{ىvIL bLh uj,DUbaժg=U$XOROvIoI?pU(=UM!ZkJd{bCDLiqu/βvHax<2]B.DK\۝(ܯ<~G9,&(/Q^*]Y^(]pgc %L`FT j] }Ao'^Y~X/?/7)ނ `KA{0]ֲ%&7I+ΌﮧM"m[p䞒ð +@J:dy"SsYNPR(ظ-vt7[t\2Qa+In,?4cqNqh 0^V_TOB<9AJ:o[;$_O {^Rm/\)z1E.͑H`W_1CT[dDq`99!@!Q#UMڏ[^ϛ,} ׁo9Q$Z0)@8l5^ [Etg$џJy^@oPgzS5#Nžp醼lJ aCO3|CVdN]>)8N9d:u[6qJŒ(tT7s2`nfyz@DA0@ ڵيp`3@XPM!ޚv~c(k ;YFYZآ+9J#L]ԷTp"\Uu8$[ZMы}QϜ;Л[s03;,bj;r— v:7ݸѵ]>Yj8u;Û:o "7:*IY-TiFۮ6\},5o6mV~pvXt?~#cxPuf/@wiuMk5Ӄ.DdIHୋcJ,^Yc9:au`mD};ށpH~lWKCA-T- z >&p,1S Xt596},9]sԤs+҂i`sDsBt\@dR~>o1 'q l`ΒKE@óYGb{tG'Ár8 uty%k1!(;4gK7>"3^;fde?ԘnTsJKG*-|rǃMh{[pv9{/QRǔlڈlSY X=K@%V&B5 91[J퐭udogwbܽ<Ge^cqQQgʱ#qXާ x$j= OmGUBR\R"5Z-HSyO=@b+_u1"G 胺]9kf$g~d(L  ';[P-sUh*U1b _gz B$N JN~]9”i)j׉׉$'x3d(CIn]j9mx_QlFn#X; '˨ܐndxN$>ܫH"!⸽ؽ6_\r)Fwlk aOGY?3ƕZ!Ų5g^;At8w> !E궭C9gX; aHW[o+| ~}?(S:LԏzxRui\yX]X0Ymv(i zSx)G yUE<&z0h,*}Usk=tFrC8/݃hK~2ypH@Cx}vz%h=}ARn+>xQw+74q]9AhY|EQc_UqXU'[A¯ ٻ& },H"ݜsi2%wbMd(6N4oM{g.nR38Ze1Wj%&oZBKWqE*#|H%8/md+$:)Uj}N4o%nQaR_!bp9?'ħrK<@\o5;txNܩ#6ݵ}=V^KJo;޶:g7TlpT{1BQB\Vg.B*u;ӍWC[a4ZZ;t {XEʪĦeVΐ?%TԱb}q8&>|CZa01k,^9V-oJ8u:>Z^d 0O’yV(ER )8;|@IMaiɏVv ݄yʫ#4=6ư?{s]r~7Tu0O<2 l[Rf 1_\sB! aw DfulCǃ',\:$Zth9xQD@pC3F}PoDz=ĭ(TNOƥ==-jS]ܞ_Q.RbC:(boh%OEXF~Վ1-/h;F}O+Qb [ɴ{p~Nwr+0P]1:BW CP;'asxuf5U8 "'1eNV,]#JPpu ̙r ݹ  19~,V]"dz⏓ l$ߚx pn\nbR; <WmL ONT+ԁwD$&1hux_w8O;jăcq~U5(XJ `^5bpe/tdQӠcǔ<@f2oו8D}rd-5f?XřQHPd`_Z?=}& ܙy ʻ/il[' d / TABP,Ӻ =;-SeeIcI =pMʿ$ᩚGU]Q"C1'q݂U{Oxyqk>FD$A1M3FHȯI031jHɽ"1i RcuI\|d&-r|]d=AE>TV6$|vT'yvJա(H)E~ɑ6_#sD肜2 Ŕ#B{W(|h:*locvORyVsPm@wx]ӎ[RY^dgoNr jN4' }@z]K@Z8mC <ĺUX%ejc6.:ӾD]mwa˳W}iĻe&7pRmZnӯA(g׿˳O HM\>%.ٕ2 }08j=]'xeնFJ2HN:^cQugkԥhYnhX[An S,]nBuaҪNQ[-.Q= }"---@}vՊ5Ch"t0.-P=Er}Lo&{O@ddoը{%O x~d8j}%)"e^+{[":#: <LBNlM^4ʈOZ{>(P!7?ǩMINޛ~-|d W`NQw inU•^?r$3-黻!vC8-"n!Q!k:|=R7i~=gs:vvUȉhw[6A?*ɑl:E]c QpDSV5@Qd0x!NQt4S&O;82#] 4D&T|_ܷ>~k4oO`023Onv@fO|eyu!H'0W&j5dg ee L`\? jqcr^ĖD#ĻMKfC!̾\B@!)$v>:Ф@`o0@,WO9Iuw۱]f:@m,௃q`=~Op2nT V;U t= .z{ׇ;)xi;b:D^O׈D#сd".*cyzhq=*. ?^H.t{vK9<`shO [bJz3"Z@ ZqN ?jp՟ i" ^mHrs@FwYI ZWέF(]ŁEo"˻i)k4 jϖ& #tI[g oVDm1e0aW0W9̽oX-"c ߗ$ Ejl{2ںV悍<4wfDU:?SPr͂fNK b!Av%=ZyJn0ۓ4tV8XUE9d==p*jW+LS}b  D5.{}zӜa܏ҥŗȱ+zFPH8=WV{buAw1[}jsa\/o\s\U{o>!I1Un(Y¦GUj@ũNu5Ov F}JBׯp*qhIfT*VGn0օFRYz4f}v\YCL-&p\ˎ*>LFCWRлۂV,z\SE45h8CpNj*I'w)~Hh)o{x=.LJji<1yª-\Jc=1 [Ǹoc0S,q23)moެ<حQ0'pEyh%x~}\р$efSu+q\vmdLRÁ3b@ weue?l[f^:CB9VQBկk'CߢHc"@ hawJ Dȁ:nhù67eDХz-3VS%#fmD$]0RN ʴnòB7iq@A&CN;˚@\Y|8iJ'fUR\|zV/A7gbVL0PA8UE|Jb@~TUUT-rJ܇, g>s٪ ";^T6c^ɮÜ w fuUE8ޛ?0cZ6}esQ:¼<'b,Ss6~.۞}WkTM7ӚXP6Qp 1o& p:YhǶ;L+"|EFڌ2yv>wS%|[ot `#)1%kkؙ-,e?eU E|YlX:MO,<4:aSeAy<}`nI+Ym?@ʹT/'uͼ=?!ڃ98¹Âs[,ճlGoɴ˟ IOK/7 .g"o,kzu[9L/z'x4#Xqv `3Ə_ǿ>?ϬRh耥^> ORY (0`e*' ?UM?cyFeH{'6Й:>/nmZ0#S6@1T'`ii6W6> s{R5k~aS~Mf_j%7b/ceZUW4cپSúV?븲inĤ&4Y]#R»w^ \%`T3dJf ߡX_ew~y%DqD-b|m>Z*+ 8Ӂ]?U]I:E]q_#g ݉`o%?Ы4Pý$)m_[$A,E SX,5y0@AOņU"8"xh@Bgٚ~K3TAφv}ڛ]ڪ GO=w@"Mv 1$9:sԁJQ$ Sf"Ui2EZ;P^ :/('\л~> { *sHRqtR섎uU|=<2j2Bz5K ܯce2Jє40,xQa$2 5/q 텠ٔ)2s *J 3T}+ K.1D݅  FOTO1Gg*;/ 7a^  !.lH~W)zQZ۰sM7{V c[N`vQSQo. r6Ќ*gA\2{1ޜEa IDWȏV[@Qݛ&Ԧ#p)a}gBveU6۬T)YUɷѥtzpF?uٵR r'i |>{kQJ/tS%QW GӇPcC@=QI=n"ݑB  g=jdg}]+L6 +2<S37  қ4Neqɂ\Q|*p1U8%WZ $}1&_H.7)_NܮX^QEׅWBcoR@;WȠ%UG﶐׀w_iwRY&Y"D/D~kpȣc!+UvK$yitr^Wr LJ T5.v-AJ%4],>uE jnEl; Qݧbrۮk>3DxI@c @ OC:ìӓ5Mn@-U&Fw+:T{ I=jzᡢÊ+`Zdu|hTeJroj0ΥTRi: u6Wq}&K!LT6f.|jlwk{, lNSqItFJ큛KRA7/}a] g_kntV/ _5,W莡ST1ĶZ{)j F0Hn;\Um2nPN1@}ڳRRgR)[/6֧ねOAjӸTV KG( >mlWzizOy#WҜN}z]i>.S_S6#x[ziҧ<>gK4Acէp+W}@ҧ } 0է.>=j8!hOӹ;n #0fȬіb@j/6u5ec |SQ!xR1B+=M5+lZ唅xl s~Ao?;*#kĝBW%,V/x!Un@"%<:Q*&ugbSFMSeh!a@~^XMyzId1QdDY-.l C-ܟ:.5n|`ߏ jr[Ͼe_wSSYrޅnߔ98822Y/1H]RЄ14_O}OQs<z}(3v0n}e^ehi ;ߔy{!Icfx<rӤ-#hACwyqVKsLS;D? uJ>r7$۽dN-y(GΔv\[vUيk 3uO2芺B~smt1vVؙS(1cH2G:{aLL]Ue]b8&ݬ\㋡o \WmI5_Bѫ6(Es>U"w_))f m{@Pm{r^iJ=,ĬlA{1O$+p'l*u0fH-YhiO]1VFvqub J;EYU`[nE5;GzCe΁r.zu`(dEc{k8f{ KsZd5Tw>3Z 51GA9kn+kq0^رŠ.`o ~ n2a̩'b"ڍi%89$Oȍ ӕrIc}c]+zN_ٯ|.zټ]Yt*)'M:y@ H+9١UEma Q%s爹{x]S[գj Ψ/i'<0ά~e®?EX+^۴3ִ3Xv.۴s&̄]_Q*$B6Eqv"E;<:8i:6i'_ڙmM;afN\l0{\{>"6la' <\Y ;P=:0CֹlֹYvSgu`[ ;}vfդ߰;4hWt)N$c[]ږmo2ܯ~[sD|레P9o2%_e zJǨWPujjM,awL &lXLEr&1` zaZB}3đs}F0҅4U7lH; {o`97\ Ϝ}G.s򨠃lox:gr+= l+}M8߳t>41tv:5!#ߞ%@|v} 0nj<!xzy`7>G1-JQp >igZ3 ;u i\_=41gxAXv8 ZZwPaw'<M@lli!\ 0v>i6h*&̱`}%$GگOk'.$O0V4ce˿'jTOx8'"9ϣĜ72\x >#P^PzUay}.䋄saOs_'Ğ{za~{T04{+uG܃}*gŁ؃GîPhr=|Uu/W״zh랽!{O=9cN(if#/vU cc-2"1Ny.YgkDypF 8~UF݌6ezV0j *#΃Hj%tγc/sɛTCeagk6Y\jx$Nr+ґVbaG--0rFnz8Q^y7cY#rф DЦ- E.(E"JY42.=ˮfq_ea?}>|YdR,cbĊ;[s"gCSdo7kT9srs:5 Q,wXU܀[t{*Mn7Y0 A)e :8Uei!ϸ Dn60 ."4hak \_W@U1R[ӾOݚNi@~b 6 vp9sgeiXpCflTxq՘gfe8ؚꕀ3IsiNWMẏh,&1Kn9Dh҅+ џ1ڋN$M0?N+NM1^e< thg3iR.ك?EP8}9΢7ٙv*:$3<2uDi)M,э)#jT3 aib/;l50;P\Xo9Nxxe)\$m-Z0^+#42^Svp]ƞLPU)HDI /j2ȩ]_#R@T-Y~X U3_@.T +R宽p4淚M2? hx Y^2/l|kEH;r8 h;{T^˶wK㋙yOmg13RbfΕ|엛6de< g2z %bfrs8bv' 7=1Ŝy8n'p`ZKqHjݚK4]^sN롱@ ,*(PabJiʪ~ ?_++p`Ȅ,F;O[s9/޶R0|l+}[wSZ<0rg<^Rk\2®ԘwI{%:ʊ6t+_[$6?x:oD&G<H\H :[.v KF98FL "e"rri=1u>X(32*d,7HWYQaŠ8Lx[ek0cbn%S^3tj)@nS[/؝O#-/{`)8 yh*4RdLüEfܣ\w3q4vqeaUѯl_>nyy#i)g>~^eϋr|||0Il웈>raLX|{RrȾQ:ƓDGorc!*b^‰螾08y="6f;nA#}E}¾ \)3zހx!)pm[gh"}X6' V7Y :ỳNIP&A3n ě9@گ?8QI? ˴=}l988􌗐 խ~X.emZ-0ڗUI&1ET|ķM h'3G޲k+%U{2_F(ݱΈ?wΣ&^\k/[JMWb/J:+)7?pk־%D=U-XF Ytkdl fCl!Ƒh}c%CI}^ohcyyD߬Lr[/G4 ܵږZATCHvBip+5(b#/#RhbXg^`j*h:SJALl| &[wHWցBO-?^u|k[2&`xE pU&؁&D%> <=֫l?@Vymm)U<7zVNO2E]O>g~%gijR`<,wF8'+Y;do#.-wiqƄw  h轈5+ k*ŊªFĮyD^a3*fkwr{T!DcZ` s1ݕorĜE|RDg{ѣ_ Wyhnšn˕ئ[pzئw8"l##S\`91B}ΏSMWy No}Ξ{BQ`{]%8Wо#uǛ_b`sZw9|i"+f|y"Đem3%lA,guh3gG >; 3nOvu+ B[}ͣhTAl{^Ś? Ah_Fg flVl_lւLqyجe'`3d326kޛͨb06 i6kuf0hM:cy"˓'g31Yǥ'Hf1{6{rdQ/X<ƗT~h0g_e (bK-=R<ߏ|3&qAV'k>?O/a}K|. fKe4n”z,"P#duhI ZB#Rdgdp7Kwse6G `VQ]l O)}Vu|n(E 3.*C/͢Ѡ I_: 'Z!%ÊŴ?+1 QE]4x5O0pf`e8 Ìbg&*eB!&ŌH%D\BcU" ۖ"@lr9݆FXX;HVU#kHH BDɽ4T+[BJH:D 4?k%16SC*dYPH9Q "6Ȅ!!eяzwrѦjrȾ 6҆ ru(N}BN7v98(iP T]J`RXf3+$DJoA[w[˲*_I`(~ʆB'WqDZom8|EZ6#uœÚ3kWv D-7dQ1Hr*4ST@v,QT 7.6 W.оr>h#/ CCA?%/\Ͱ@-ܘX҅\U)$9M1F3ߏc,>B! N&Ž\MCS$vΙeSGP@De٘r1SjnINKNm{J?_!/] J^+^ 3-t#!'cI(&F#ȼ%p+CSo )6'lײ0=[lwF\aϥ4⎒-Z٬lǺ3z ,?[=y47[R8#Ci^UlY'`%W܎.p}'D]9"|!1.|Pȵ͇C~04:=|;M+=sLa;ay!H-͋H!\#7ޯ;z&0N8Kh'_ OSPBsUT}Է26Nܧ\*$φb(:Nx foUiظkU-_XP0z9л4l ,&`r7ٚ,q >$Z*`(iٌ mB$}zqR^$4w>v$"i݆YLҠХ\:w?wX=wL{'v= *񚱣WͤbS]E::M I pgsl0=9RuIZ^tbِEO$ymB9[zP֘5fxQy5[ bHSsKCUw,InmΩњmY|RuӖQZ8\*Oٕdnvu$ ܓb_P-ņjeW)֤-GwҸR)fTU5A4W6KF;j&Ic~c9#]a}ȈLjaލr~h /DYY\kK8Hd8:8,S];;ow 37$Gy>ZG^摚GbZ?ߏf% e[BsGaING*{s^aw:+<ނ]y%}ZnpA= Q1wWԮå-,.pk9ۅQǵ59z,h!<l# _>.Tc|4G~p4=|^CG~h1j1082ѶOOA3}.vz,B/yyR4 ޅ'!W_e=@WA1]0p\t<1pY/i/ep{zLnpj{lb{OsnblQ)y쭔iR13s"wWEKY{RQ쥀(vئmhH3~Wd ˞b]ItZ9XAXk>_zs!+ @t43(R-# ^ CFf`I=yrfӜP=/9o"OՅ(\㥗qb- mB[- z76e.'-#OJG ȷ+,K%"i]u,XײIUﱩ"^+c_ >̥s,Ţ? y=?-ιh3yQCWc5[h,Ӓ/RR!*d4M:7MGebZ"0I#e*Q as@)3):A̒%0?Z$B"vۍ{s|Y\߁"Zޮ?5W3]Yt0,.b+EG,6lp~Р>; W&%FaE4 OZLJ[Tmqj0o~ڛ_~_͏[ q:$Ao~SU=N xR8 ^C $ͫ-EԻ dj4vcV<H'y%¨pZ{rlߕڱ5Wvi{x(,ui{Mm/ɢ0xۋqkFϏwqQDC4 ïkdE^f9ö%ߡ7?% ~Jҿ YւȰ1I?_dv.|%b="Hk$V΄f6F:-GKHBؗrfzȘ\ӶPٶ1l`[Q]ev8YDo*)-`ol*.L!uXLLPXb^敖R`al3(0ljjzU)z͗J&owU nvj>~5n(BOحa3N3+W30Iz*JԝZxNWj?x/x#ݣc7M]!QPIRq>ykKHn*"Xhv[`:?3e^C.$/& G:^,놛ǩFZQ\Pag-ӮkE VSf$z pIJ_^W|RKx¥݇F8΂1ar21>"kԦYe'u0z'ԵiZԌ!+5i:Y\-LMݟct聡/nK㳵-)M{tCK+߻VgdYkPM>`вPj r7Y Dcq939cݝ_Gd $k؎s\A4Xvl0:ģzEC/W+J'oE]Xv0,)ӾljRU}%"AdWxE]ꌄNƒOapYv;ZLiP,cXD|n3"s/2-eSZeܭDy7;?_c Ɍq؁EAIC- &c,7,{qIwZsE X+D%hbv Z1+NfVa\ճ< mJ5 8 >[q,f (]AzT_+e4.%DU7!,Y\NZNvI0rF)|>1;4Zu ɦwO YrZ>0hCved}?j'p9:P G"fe렜Zޞ,a Wڌ_>gJOЕ6coOd߁JFR} ³<|fK߷'a/o=9Z@Nau}1$j<%ckQ& 3j:|( T>Ol;ޮ?}VPc`_A|ȲFL5O~ty1E((WnjI:_X,Wd֔XKuYbԋnZVd/K(Ed+ _(ThGU|+K\!o)-Nv!WLۋ3hV7>J7ELϹXQvCL"DTFdSJxiMf3Ci]@5yH52Qn1bh{Oů +Ɨ`.ze6?|ԮՍۡ`J^kZFǰ^1TK.n|nڌ1{hmPuX Jc[f:K$IpRQAB~_IFDSi7 sbA}^ay0[Z2<;G9HC!3FN)5wqEGVG5.G3i,UވvؚcNBaEwx߯Z~ }Cb:/M/J"*@ ~#r"Z}B2KDxo@VHS"C[̥Vn8PeU "T/NM1$dIþKY|-3PĪ.̓s#dS)N.Զ2I|Vj+V/6FL׼ϑcv C~/{7+9 -w.A"UΒz" 9K\Օ_jjTg{XDЍbHҦzۥ9pZ<*>8P_4nwi-rmQ+Ȇ G ;Ti8J5 9bfX MW8A*??P@σX/xӰ4 ^xr{x7+oEwy<0ʖ߁FT;ha7/"Cw7~PB *lfTXcu~M3BBcS `%h gvO9R5rIQ *I߬M5nšH,+Y7tu !1mYV OA8XgyAM5|Tk@MV0$|I yLcjXEQ+ -;[̓s4zՆ`^ι)XҮZ* =Ykn9(TpܨE=׍)FW'V=OaoO&FRئ*k+@9T"<3S}WIKNQtPC ڍECȧk|jo@rt-Jifʐiq?coLYy  PCJ )0y#e|SeGƆ@g&~&c8]P-#Rj0;O/yNQ;~rw9h)~S:-0Vh(m@֋l+ПװP|sՃjT-Q7%[W[1=}8?ZH3 P|,1YxV׼3f9M~!kDgIҽUz}'f[rrD+l;q5m F~7]Ev1t~0봚yZo^!9Pꁖ[b:3 1^ٮȖ)ty8 腴7J6hU$9rJ"I8?PCo_/ԑך*p`)j!ЬgO 1nbtP0 P<$"^SJr;u.*t.$H`z zKְO`NT_6]E Noe}Xvz6Yb*(\ıɎC~,b:"D=(2kZPYXQ<;J)4:lU;DS%噸yt Znga9xH ŭƄmOdAw\2D<2֤dAv}aRFTrFKPLx<"XSjD&x曚=b>}WmdGW\.Q!}!X9GtGtt3s`!H݂VkM=۞ y EµM! 7lUлõ)Pg,O]5G(i\vd+ԫzD+DVE\z;n{~!{xkjE>xkZ B̓+v:m1KKK&" LG]gH{ jC0un elIX>Pʞ`Ki~\ |['eirX"USO6[GjWsr~3ATV}eNMe ceQY+R-Lrl*o~əΚ5*IϖǖmҺS=iQ>[8wJY-l9sz.Jr_^VZZ>}@wӌ2׌ߧ?φZ bg?uI̡e/߈X[5b5ea2Nja 2mr cILQV$ ZZp`ERK*LPmE"5 $ZM1%A0d^<\brbUFdǶ8`[[V.8~_X`^0& udVeª(D:jR[ $~`vդS wzt F)МsV/Oj%/>9"SO8a𩁞4s>`kb$M:1T"6.X\ cne eP7>ƱV{{0N&0[m3.l*K=RgYDż^L}oZѦ` ZIЋz;/y(+lgؤv.E}O~b|ֱIFfEuQ%c:&lJsE\|?ЫoLQÜ@n]`,$b2hdw FtNB/ `G冮z 2D/Z{ANky)mB7"5aT ?LaW˿)x@ZwU~Wۊ񪲱9@YBt&RňUQ1cUw!+w:Y{v-_gԢ6ѡɮrHr$+xmFV@f  @.-\Q.ٝW}W~up+%C t&m{jd|Quٗ}{) ߿cKthÊ٪(Zu4ʛ]hĂD`5$GcExGå6q֓˖7q&?Xrk`XyFЎ5BpTWGp"M(qnqPZa̵OlA /Ѫ]hX:1w1l9Uhtء9Nj6[s0R}4<@ի9*u(Ȍ|ӓkVDr]ѨBrHg#}/qxj^RfU&R2x}ݏX| cL2w7R`5tlwV x/p۸gw^`X?﯑Χ[<;Ճ-NA@.P)/MV`3ۍAsIOj̓P~YH(Vr/;\A;SX!`.ō(MbXngGHBI]j06:<%E͎N;-@ \k~)EI;ƤLey/@ft#=hJ@މ ڗRzy.DYts\+x5~yt!M4ruJ" Lԫm#0d*E̅^dn/f Wg`r챻e6%P{& a٫2|ӱ[rNٛV?EA{iRY.K˜io.Uv8ڪ~Qw3'ɩ81ʕ*NG4vVJbu{#My2DjUkLiDQ8<^I}3%/b5 "O3IHڄ!hƾU)N}ե*,;;5ܭܮ o51%-n T ӫ Q~ZC7yp)Cݦ޻5Qc̡nxN{Etͺo޷L ouK;;\F}V⥽5nF5M==,-Y&2PϡR(@҆A5 P9iFtlEq_%/1.fw>ȼNii}:9^6FrhrgmQ&YF8;saMO]>mp ][[@{"(yU*^dT),< ڸI5eL.I#+=pa!*8l|4ײwZCB\(%Oy0C3KeF(բ \}18/g/~Z4R}chR {M6~pnzJ\ݓ1Ɍi#ܝc_O+R}{.>pEt>}4&6Pq\BVF"L؈6g\DB[T/#/$|t8ptJN|@uIj | 齁DÊX2{[Z,ٗ6VIbU)3]onl_lDsF! Lc^:Zr" .Ƣ2?4Ys2qS'Fj$onD lqdk T>Ufd+AbQ2a?szƕKJңsc˲Ip!ãΥmn|sv 7$]B^3vMđr鸷SN%)1{B:k#q:x[Ss+-'K ngUΖ3.wlZ qVǖ;<İGMQ#Sf>4κԹ`N(zov+p4Q9D}1pPG`٬iS4Ǫ65A*Ic&QUXy,S}xkHTYLF.hƊ A ͌C.VÞVxg2]q+ѲנT.Hh K zdY[|0+:Պ_K&OP%UaBWX\^ha\|UQchV";a^WBa8{MaD~4T8pup2CP@ gW:yF{hB12b'n(=y~M/N vq^@ʐxⱃaKDN.g\n7IU^27Z<ҍ]nl,5nm+^Jgj9Q?#AYfI%$Եj~jeP@k*m{EءTSjuc0'hIHK3jꇡ 7RpJȲun]I%NÀ>axZ0.┱(b E;&c{fOhxD8uNz04 #g@RsxuD![2F }q=ԕ%D|1U 7h[:nEط;vԕ΢Q)v zE-9I|V R+,9SS eNpv-TZ c-Tk4\W4TB,'isChG+'>(%ocaԮwn.虠Fa$CthA.7*Ґ+,i 5vVOIwu\_YeSOguMnPۡaH0 i5iOv|5?2ſkK!  Z{EZT5:WJӖqρgZ_$ ũ|t_cZ*_nľa(AAA8+j*}`5R4MU\*$,5ڟvƏ5~ c /:uPk|o<&c0b&:{xQ+S&M#nDC/w#-\"xrF#y0(oACaqeA9R36=eL,͕,8n Z)Ĺ-9Xx_^TG.{M5vA "8^ez DJc|n mz G?y/^c+)ldqyQ֏: 1LZ̲tN h`RѢ;uF XGB3Oˊ"ts.[s%:8/ߞO{TM_akRJfj(d~ScwtQy? 38rξ!T @Ʀ'|V"guυMy32+g&-Yg.#*j=ӿa]ఛ -r(GQ*nWyKZ7h8ts P_@[W/9A:6m^AO*Z K~&KR"VՋrG}Ati[-mL&6›:ʏ.{);N=`ƒZMxc؎r2agJY< l]ymʸy"s WOͣ^͉rgzg7aJ TzuӔRUZݛzwHaGc+7Bew[%Ly ڑ2'(c7;7B/TYǑm@-nZR {be2aQ9 m >Px PT-gHBSikDrh4(/ 4Dg݊\a^@(XCQ(ڈYRFm7/"`a򱐔/Ϲ+f Y2k,`ɱun)V54q[['soM8I.ܮX"owwڊ S;,cJSLa-G~ 4h] h $6U "nJe gM8`[DRZf1pPpdE1@/NsW8&&k%fg:+YrV3QZ60~ݏd(ĸ/zzl,$~"\vmmʧYJ w=iǩy7n') D`3n#-4 QnHs~?%m7_ Ԛ4c)= K.T.F\W,XHIH@^ΙgI2+4h3T(} I-nhItiwvW͝Iv ~ܘZH-rRq}@ /DNk;tA|>oz5'U6ZS~ lF 5T2 d4-B;=#/mB_XӔ@deԽ[7J4#uR1rLݭmΣdԙ3J1'lHO+Mce~X6^L`n' ,=J"UIwiQrPz?8r_M{Q5>_P=QE./|YY*6[tsV;ʄn\Qqx\0{9M89zu|iO_v\W@nb)LyWזYQ `4&ޭ"a7R%gf2^ Kq8Qͮvq EͶˍ'(?|T Nͳ{yJ[ cj 5i&u:kY\/HXQfBix(ow&VOw_vOYk7h$|+hK |P>oiz_~j%7ẄX=1CI-3Ӟ/Gp;xҼU+oBwDap #=V]RiDBL5Oc+>}%lŅ]6s ZW_*anbY,UT=6|*7#ۑZ~@Σˏ\sN% ZYj^N/9IG[10Pρh +6VP)U21UgI@Sb4_Ñ}x qw6C0Tՙ@{xu:0Lm/v|ͤìAn50^%yQč-b O蘺Et$VjDuw pN')~jpv|ŌI|^dUҕy 6 FG+cj z vTH wA! + 8pF߰1` n@:BvuX>U>o-x<(,'KTsꃰ6lZ2IKbl6Cٽ^6 * L˔, 6#f*/o|i7:m:b &T+~UNH+Ig q}Bh+ Z Es[LJ,j_r1JaerQ"]Ƽ_N "er@dP6%.FW&}C#(J+hvY~Xɉ<${cw?D,'SzSz Q&bz\PFN2u}ٯ`"eDoϧ&-=pD9 V`ovwٮ  03;Fphnl};g^|IsT;Ӭt N9 #8q}b\X, F͏ GI`-h)xnp_naox 贉d!#q18ӧFBMʀH7{L=uiK>HһFGҘOCA@-QjcSCqL}7VVh"֠qYJ q:]U&qFD c(֪٫&I#RT٘uIcģr|^;ګ4 K_i?4y˒ Fy,]@x/ IXqaRg5}p$VNvJMpD&&'Pl YYXw:Ľl*ZA!xC;PªH”e'ڿWa~AJm+:+? 'gMЌj>|mQmɭ0rFL[%.EЇ/^CfbPTAxO|^yWLUbv:"=;ǃ y).r)#lU[Z3C]ި#L?{ U:nՂ}h nwiP&YpnSӔ]I*Y8A x[ 52bPEHpOctx^MX࣯~T⤸;D8t.TζXؓX˻Ovcג밼W}4y *_'>J(d?K :K޳a "~s1fIV>/u7o)ƛ~+Aq;.e(DRuhi>e!K;~O%A9Nw~(,"2YNE҈#UcHb+r`D!px Idk$%i&}بEYfuߤ%r&2s3k[KmVImv3Hp&Ԭ5֦{[dZf AF~XJ$b!,~ N¶wҪ@c4g$^Y(k^g,KV=Z KYIsBak6mEbU>9VǬTM ;"ix|,wK?.Or*ϗ^Cx?v -ٓ>L3`E[gvfw?Z?Ul(qSCmrSm}UYڂZw\UQzǂԝ?Q,[~7u鞛Y]$U @nbwl_^ hWEsj1@qδ]}k䋒 cA&/Z:!^ȝ \CWJ/y逆LDH @|DX(_FTCVaF`1sbԼK-aDŲZheU /s aQk۔F߸i,UZSðgll_625ce? 8;_$eeO}n cހi@w#Es~) 8k*PE.CXd9߷S.9\W4s7_zA9ѯik4X"6xtc;*\3lQ 6v񙭪vJ9t#UIuK/W;&y=y%m! QJ dqF{aK ] 0_0&w6"E\vLO ¯FKo ) YxSoG ;e>SizQI;;ʍ]"Qt *cѦٴDHc >88x7WG)aRS\b$o-D"y8x <:; 'h~cOSΓ./6Q$#˫gc )~`,,1 O&bٛD@>+=vG+kWaiŽJ,%m;%!*f4bR?޺'O?౔7|ӁRfex_XZ~B6X+Ջl3'|e̞_7b./&+ dq4΃>/~@cRU[5Wl_=ua֝9V҈+Jө0y|I)hIPO{&K~BH$U|wEأ8S袮#$we%%ehӕښUXK1ڢ E_Lfy''ͽ~^/;G_*g\Z~NY :s{%Ɏ}rH;#fCT˳(+vY"Iĺ|.H=X$VOҔ]CT%jEO~ ETD|08#MOlB:y V הSWF壚DX8u xhk bE4?6qBxw|}`Fa9{AHzJwn!\(́? [ׁ+5QCL&bܙ6(J_$Gӯ5L1G,lƤgJ?shRY[xCzMKXӷEኮBcEMM^^(`*µ\*<8NBϿF8_AkR) _=-?.Ӄ`(#tWDaE:pS6`y#f:߉g8GK?܈/ $ƕ"Tu^+W'I lxdԢmB2w0CQL~=֘|J#Wx8v)xh$)P0}K/Hh ߁}Gi" Fd8F2kc&>W+ |@%^ 0_^"ǎJCZ~eBFx00(H5>^ C6x=gަw/,A;;һbNp"c,i^!HX[:P`Yrj.%V/`~ ):7Tn:1BVNVa5d\QM=qE0I}8O`Gkݣccל 7^YDz(lGآ\JFE+0ET0c?Q?sְM)thRWE0җ#{&?/? +{nȤ\ t@l׻ nw‹( IMl BfeC\IxsR:3`|Xt(9R9&d@ Ag {E!c}XD=xҥu *Ցކ C> {=+|H~Da#ѰP}JgV86`"C^uE. }?Y@yтxķW]9-ICK[w$w G2|a4&;YF=စ%gu;7r2`%b.LV=p䨺ZgCX,I@IQ7HsOQ] *\^TCkRUT#&OSP+3 /IIQ` &[FMd1z.mKhFdzm`zhDbnɯe'S~gzO5VNi@*`ઢm ~!nST\٧Mm)OXyS}\+UGR#զ8ϥ`0=W<˃ҳ掑r_챓WR#;hq#I}R0E>[˨^6zZ R0$-LO}"o;9k53>?WfT$x#&rUW˧Ҵ0aRx7;kg"5џh" R;-K\ʬ04`cfO!/ Kؔ<(Z.kv|-ʄaSu'KJ:iUv2SiА ltQ%H WbqpJ0SR?0{[t^k*+[?Ui(a 8/܍*{,MA߂%)_x+"r,=I lGkĂʝ;X@|xxZ9JsGô )gE-+@X;بhƞDGxQUkk+n7}4kg2ŲfV"d?g^t8_{?9O(i{jky2JDa|n̕  ,d@?)wvxxoԟ`xZijI8;DCQu-pNhag-Y`EYûO$Y4/ByX(wnEy,Zr'^Y8>p3)/~.EN*' I[Q,BA1})x(-b+~(ϋb>x15= /^ { aiyGtl>Koa6tcz[l Ў|]5ĶrScc ,/R?;`>(*,h7adE6 @"P0G$(m`2ÕFsZ٨6I R⠱-`<&B!Ƕ ye\i:۽zA}\XF`&wK:URȀ+љK;[&=, '@k@Y<.1Aa T+ C*Tjn ~ R"R%6l_\;=ެ#pt Pj#|ڡ|=|t){`@rha"uڋ|l5 R";jr5;>=ֻL*͗i咈浀9~^OGmkz P0g9]s]a}*z+Ct(~M3j]Y}Y9;0F!&Q xaE6 5{ߤF+;->\}^ɒl4=.[vȾԍcd})XرSoMceZNLX1եzK~k[1R\#w=X/GA`X"o~iN}p 79JX'H-<u=2Fx[9طddAZ0oҍV6JcE7igj=X%=հ+jw^id q0aɯ p9em᯵5{T!˯RHMxƼ[ /3X>T'X:J<de lo%l7~x|%J6Zʶ>t@/ <+b f D:dda@FY!̊{LU_39Cg`ߒ_)ضqKO&Z>kKJN4V'TK>Ȼ3J'L54p7k`en]dXI|֪cBYfo~!P5"5϶I3 W s̳$HʩޭAUh:{tdĸ)*  n}!Iz1`_n#_t`lk7VCN45=/MnL{ P&w6z|O3Ek_wУHLc.ᱞOS[o獱g#P9*M\2j+nqS'l%3pNUQ/̨׽?ݒ* ԱXl0M9PVO4ьe}٥: PBS@s> 2|<4F[s? g f܆>,a- n.4tD{H2 j"WEj|MT7QE\Ȫf+ɰ90?*%40(խ'Gf!eUk!Orrz=0l)7 5 =9 NhT+ :P4".]iW3Z}{J KOB:8Z~ag첟p2SOVN._r6C3I(z2(M07UOdIOc)O*nLK=sl}6/{QRi7_߸(ǗW [ö]V頽C]fvoݞ%>N(%ư&sز?l7cyClSLjpzE.D@5|bp5v_NJ TI`\u)[ｷOǛ/_c-ȷdKƃ헁s3rJ??yk8-ɬA+ sne $+h~䌰/_1'KTaИsrCKqw&\TI Xn -2]ƮKG֦0IEi0xo`R/q-u04 .0$( *QJ 0. ?#铁KN 8 K C `X`(d抷ԜifU喅HI=k:&'}9i+0Ӂ {^X/AF~#Nc!ifQ9k3)Cv*̠_xdeVp"=;.AfM~L?cYJ2HUEFR$ed{ʠW`811EdIϞäHHA *y KvdWWQ>zyG͈O0:m4eXxdQيvY'ȯ[tǟs=*y+-@a=]lH [)J\-Pʡgx5- Gp猓Ȏ闰XC00YEtԺv1M|KXoJU쁔U{=,)| XAjE p*Eo$@T:>_AW&BwXJqJ=ӎv mDmI>7Nk6-8{%gqg&O7w> 1a!`U@m:f{?fCKL\Y0e#,/€XtfEr/3S|ɈT&xI돚OPp2 ^s?aۿa'a䌻t2 E2%NIFs6q8c rsFc)L6\Kx;vWo::/hN{ ^A\pHR<8~iޚk} ~O[[w9ƪ>~ûasq_~mykB7q $':H3D N_O(X};4zRFv?RyF0IP;{QSӵ4n:Jf;ԅ~&3,S6C(VNX8 j~`M)miKIX զ/tXښHr eOl ?{5žNK$7f}= _8vpp>ބ{L/&߂lEةH`,,д~8oƹr4u=GpJ%3] Ne?%8+$_a(vSfAx) »$G( t̅e萁,Si! ,9;?<К[|(V4S!4q4Z]Ykg">kp/Wz+3e`|/Z1cÐ9-Nq/-6FiBynXmhrV{ND]2@b}}hzب1eL7Oc*'<7Z " cW;*gUIGiзA%z%Eta[p}?j@s,$x?J@-WV| 4ØCbWL"qE⺜E`I9q0ҩ:BG3W̙$PJ 9hvy溾:ҫE^>InԼB.M0bZ˜Pm3]x{'Yg~Ɣl=XTc4q4Ki%~uoИA{fU<+L} &]H@HUu6Q'KKapbmXPUʮvQS $Nc>ɴy|hg'3Pd~J#h?|6H³+^=/zE/4-myu sWMk']AWM BkT/xĩ"&2v}oXuE٥1VcK$e>T@ wJ9@ﶤ.LhGQm&܊PGhgsrunM4;SS+븛QgxQ>@}&;*I+KpFJ q)O .5DW}f ٣c_^ ɾ#X8٥TH}e;0W`Sxx׫]yX^|J 6p@F3cvIk&6ٓO^s2,sߏ>{~vTDY v)l}?:A0Z^.\oxoP/M-d!\MF.^ F,u'f`)$]˂dGM5E?bi RԄ(;) h(+BRYuy漞'(3#% CvQQ^WZ/82 AQVI6N /E!V/9F>VkIQn&$$E>w1MF );#X}\ F\\ 㠵pLccr[:Xu>"&@q6m?.yioV=}CmW7en H62p} > 9W{.av ژŦ/[mG8B0ƾ6U[qDn⑕[JG(Tm U#_vdաr񻊭Z^ U =99x_bؼݶ!^ Dȳ!>*%9\sw/</b1H)3˵RJ$(ӗ?\˩d UHoEA8!fR/ǿUst7Rk 0F~(yQ3j6koRpB3 9!5 +߼>^~}+TL5FnIohڱx>z!rҟ|-/5dRX+mZՓ7ijIPfׂJĿĸ|[M\u+,\`RJ)0q^Y98^D¡BןKsדfc~LorhCAS1XZf=kz$8OxxtK|wn7ɬHoWvSsP& 4H%3$K2d6$5y{06rXrFǢjǙfK";O?kʽظIp^?!ʪr#MP6dnKt4~[ܝUѻw#CK%>TVF_drlq==8ot0˛`KUpdtE (&r.u݋h OĎKߊ;w:X8sx%5$|ݽc=7YV)OaYn:~a8L "`4}9=_z["IWBo=5]b*# ]W[NpQ&~2OԚa+|<7`k##+%x%P {kZ{_j܀nL;ө,CrDiyyoq j.]~U^+Y` {WԠp۔-a-:13dn\Y^Pok̤rŊ8tkj<=y]rF"ӻ6OB$TP \}V%g9c,l,'--lk!\9w4aVHI+˵H8uk^> n\> \ڑ #]$f/0|Ph 65ق&Q<ՋXxs#k097Op`+`~kSN!L+5jDXW:%i;xgI Cu݁O8F1hͻS<7E9˿k9 EWpb~c插8z{MNv3]6`l0/f3HF|Q&m/% h^?G\~;%*|uܹgy8!N=/Z/QүpGd:'H.9ΈV5,EV;MA~8 9GɡH~\\lp{Mr>]l}v˦-AAi%wC`$Q8L$f-a3fEA0{z%Y˱]YBfP}QטZ\\* zp5 #U~qC~6Q߹rXt('(p۹r:!|ɋsr >9Ǎk\@h1.uM$PX{m}s_Io~ܛZgA,2U:YARIsN"DdJ&G$@rp2\KRDx~my5@wC X p >H"-I*?R2{Ieq9ekCwvNWڤdyKR}ۣTnĩ <$Is%$48< igh-aDBӃiKuhm@\W+Puʛ˪ovY!L]CȌS K.c\r2e{}[U>O˙uZN_.~Y{,pKLfL粜epZJK7?,x걇2vɆ%k M-?ݼn ;u,)rSGt+0l/jM/hRLvCwwN|moθӹ9_/ܲ"A(GÇR޶F- +7}-u,򽳆>9s&(+8} ud[!%`<0$I>ݡ9ܮ<%̲$!E*l-69cAt /’EsޓF h.نTPXO!d~ԾίNGٛ8q&(OKHPŠ1L XeυϦ1E|_ʛy`Q#%d.GWEP>5o󠸰fq&%U:ͫCsg,~: Q7R;3g~6G\L'P$ÃZo P~$*8{Tm8N<%s Ȓ%S-`s"u\O(Y3sx~ TldWnda0T$ 4dUMҴf0] )Z>^f !*m@!>2Rynb_ѝL #&[<G|TӃ][Ql(L6v]Qo ",w (z#jYQS p :z,n߀޿S:!}~M`~"5<&``HO i`$vuӣ= [f:vϟ'~ĸ5}zݘ-EVHOx+QK _۹2*mK~]wR,K_a &.|g$WyzzR_-,t`pYGheoZ@Tmvˀ DDߗ"ZX4P@&H=jV뷫^eT@L.s0D>I-xyIn%_*Jsff;`]bl109P =e>*E/JB\*& 3\,שbbxx U ۡ4 w=^r"]^3d ##c*; h::f{t 15Í{ CDt 9aEbu ` Xe Pk1G͐1.깔1;[Rmڮ螪aFw*GX08z8, 1TP0cX\:ݨ<ᇆZ3**8LEEG> zyc8D G_ xB=i1-É08"z 7s ƇvPec]75:>^8)+}_64U)ya4I^$2RFQ%M"䌼O,2jلlA#48~&'@|Y*Z`,Ͳ ݭâ -Dp'-#7|f&e+@cf(vi6ٶl6`O&ҝZZ>=$W377C}Zw,pKOd}۝Q_t˾ znD݃dkge2S+45 om8W8 )ka07e~2uҬӒ]`ww~)moQfC4Dt_vaY$Ǜ Ҋ^kMGՙ[gN:0TfH]=4zi5,cbMw,sCWR=p׃Wo Ɏ@F4HjI[‥zkz>.#aXŤ$2,5 kz\;vKWv@8z>S̛@zQVI=-*ٲ'_r- Mhq]MŭRo1K~LTEV :YIck Џ~2k95Y}W IJkzq*U]\ v|`pM+asZM*OF{ ;47e_땵|?p&6J`L%J" Kj|WUSgmÚK+.f^H8v) fpSEzA%Tm?gBAh&NQaHA$27D\ M $@TSZܒ^7 c[|A&MdwB/Ty!-=.0D`!4` Q"E.MvlSh(K8a7ny\URR$N|DF?xqA@-~=Ot(p撞ꉓ.KrS><*⦫ /!CGRfD") UyR(}F# hc3I^zc-/mƣa, (IxuR 7\J8ʽKlG7Rћvqsy-1Q #GzmKZx>R:Nԭ[t&5AXM񶋃Y'B-rTAd;h:cpWg#5[b 4qx7<@;Ys[USBfoo\*v:ƫvi]x}#Ԍn_fzK#JʄO|9s s`#H0Q*^YcZeWPsRx͉0 ;gsA"Rժ.oN+;]v7i+M4֢YjYĴƕ=ȓvEc[rV6t%VKd%Za_V_ݡCg 4wEv;凞G":=HHwCoq\vbe1FؐZw jEY/Y[k3+mtEk.[|2%^-bw( mWr!\Za_X_ %sQԶ,t' aVxH*ޥm9)H^З{a57Z)kƖߓ)TPJΡZVS~k= {㑝[]E-?7+Rj;66Q6m0lY2!7EvФ-l!UonV^vw-g#=A#'ܔ Ցt":@6(R/̷̍{UU$IyE`ׂ7VV~,d3Qg}ɽKS(6]{Ւ'rVfV[y>ήr}JxܵY1t3M./]K{jQ\.D <]XLDsQ߾A?U墏Xxx^;Ɓ$c]}36<G0g_/:e!d?0zrۏ%Z.ÍfSYQ|Ϛ/Sպғv i@'s͜ayrDaKby;ucm=ts-8u&ZO kI ()MYwQIMaj. `wu9MPHO0p$m$};=>+&6'Xs v߬15C& ,U鵋AG2)r f?55g9 5u2{ə8qO?p& 9al?h<1:PxDT?PڶEqǒG{khԲj̋kE̺A:}[u" 4u3V\S.B̙6SuC) CT6B"Xa*u{ԔJpAMM>UgS3*>;I$i{6:[GK}βbD8[4czHc@Q9{0e"rW ~5/җl"݊WNlZ4Z㨩5T h]vwuZU<'O{:nu ϙi}3DxokJhT48{TOS4*yP^d' RNĨ%"lN2 sҸ fUkӪsaUYEڗGQ^'Y#.nF*}-!ȪZ<,*c,'HZbdUȪ%z1Y۬״*ܜ$UȤ #5sU5+iU4IVE (,-=QFGb*}ٓUakIh$VcwQ`׷ υ眮1]W˫K>'O yRQw 7 p |2R)2rE(ʅnU*YR!Bu Y rN>wqI' 8ǵ^;5hӠNGEܻUW͚b<|4Df~hYfL⦳D Dk7οEb bXFyeE&dSf9^DRm֮k7A(xϦ@UO2 }"U5g%LઢM4{FW{鑦,GzD]Qf@CɦF*ZDUu#ͣD'^~r >±ifVS-8TтMEyωH11r =̌KJ fЭM4aj'NݮVAlѸ~ :_g#)gNetk 1JXS>UЊ7w:0{_ÝtZVl 2nQF;{]ٳ]rh~Nry|ګl:!*"/NHս6wzPj݄I W=)Mߥ''"˟ =@k}@3SA݁ +/> )ĕ$G1cYCbgB lS\TTVlﬞP#4@0!G`ɯ$vtu3R-A'~kl@Y-EY`:[O Zh?>zq`ى7 Yݮ>hl;!vJ[.*Wr ӼPI=2>GP:v1eqR S%g"N/!Vj 6IBHBh'0uc՟nx8ֹ;$%[ʖn=Zُ(fmEeGrq+TA? /a\倷FCR&A '(*WB[hnQe˘d.tvMŤh=;^f4)4b_ER%#ū 瘀z3x Sxpg-,r>NU.h4TKX %MwU,D3mTF9mT <F}ۨ$>QAmU o+~mW<]5~E4|#Yۮi j+گۮh߈ۮv.Ƚʿ,vE=ھ p7hWmGTt]ؑ0,)|Bmd!J_vT~-W"yy?F%`Q[9ꤧ[!| [mAt+`t+&B nEtf|4W!S#C4+DCrT5#W=^8ʼ#(,:04A=PJ6elb~2D9#D!Wbs*-;xGT* Jq6=Lc0Fnue՛ٍ7Z FuUҢAʸ VD;H@y ,]eMIx,_Z<{sRxi.x9G ak_Ajcd-hhiÄ1iV;#j:T¿98oMXTUfCXcHc4-L>(\N+9 A*;U=:2EX`PCxq=j[(bʷtG !x(%~F [+"m0'~Ⱪi(:Q^U2*[eՃmX|e OahZbn粓e}/X_ZY%̊sΊnFez)1Yk퓻}Prd&r<%]{.Ge/ߋ fg::2s*cƌSдnK|~Zbu7!eZ\2O̰vX{Hݹ,|na3bUk wꥤHqhfa8lW'\v"=TD  )N>uBIdd(VVEd (;\EBeրCghKYe Q{v7Qy ci,v^i=JYDiQʘGyaҔaYɬ'lCr j}w!Ej1Άn6e8i) ^S10#B؛oj<,% Ez ȖcGf @=~}[*3&qU gPݻs==7uzjdÇ zfYd#僞V&@|VhZ#\͡OUPQ6\/&3`>by343K*X%1G4ՎA|_AVpzhDCLPn9z]3kqBw8U۹c5ܽTYZ#0bVQ*ja;B/} ;ݪcɜK*<7}p^3ߡlj2Q,#rvg*q4{Lfr_=Ѵy-xBsx_g.p~ a ? =ػ BM%?C!zs|=N#prA.d0S>;(1I E.4kNо4c:l1Z+k 45KWcڴjg؅Qs]$ D%q_źxZicr -1N2(PEt*}QNJ)}v% { [DK@~zdclpFrFZg71*I aZPoIjtccuY*n%4TKj:oyWX0rV sDN= 1:M*TQ"ѪV *++ɟTpDqfeJoNH^Hܵ-)Csӭ%8ޏ^Q+Uee]n)Gm36%#wM" m|n0o51š $ʩL::骣N.iǃ`1zQ:($V c23@1:vLe)˾qf%2cKPܯKu'E47}EEi0j>X()_+=\uݢx庫#uȓ 8 P=EcdH/ 7\S|P"-ǥ@OY/\9&;^#ol,YNbj!u>>\Z}Ewx y`v-px=6η8P53z\"|<]/9*,ԀE8V9,NS$%=!1o.0U s>?,Mjwil=a; b E=dգۊGU]xO+57=yS(Ect4܄*Eh{jKɟ;x6.J(֒Vݗ4He4&=dg^/nfR)-VEnYg[7o췹2}@+==衎buFׇv TKXx3sB:~F,[ƈ'+KtmCquv]9=m>̧-cX+*98a/q$zjPNdQT#݀vigA9ccP̧H8%SKzCac8ܧn;e!Um.w Aqj||՟`'Z9zпvyhj"A,| $Ǎ }y2IVu[0V,2dR`,*Q̞1 D- ]yBѮqX}`bz#&"B=\εA"p~͓J2&%Gw=%$O{:Q+ٶcv {Ei<6ӓL׭keoqLZ&,EQ\k~@dHp *RSO5 TQc1UxA $t kȌZ>ϾϡB/h"hxn-fFaÞ,$iq`uܲU#O>+-@X+sm_',q}Z8 0=K!K> q KϝEir[Hbh9iaBB78Gݨ7pJIGQe7<@r\2\44QNVZj~vnC' kwp/Z ):^F4Vx4 d=h #X\ I÷YkpTfg*xp-^1CE!P']´tF;BjݼP62VfgGsiza9>Y}auճzsmX 'd'+\Qں.;Mny9duOu [ WP\&L/ɳ&ێ,ZhRң[.5nB@œ,;ijYe-}܊ Vz2s(h{}w[zr#2ж{}bS`*;D()DQټ #k˗Z>%壍]htg7#  ,3XRig QZ"a`/yqړݤIQ̄ 鰤pvPX ՛q'ȬٓTQLl=+"HZ<&6{aqBd5P#׌(kŮ0Š۸@=< Qs0MLfwKusA(Ia|~] ьC?-ʫ9S,O #]Ҳyp!(/T:q>rx;rr oHʡwl3J6f,+=*F#vg)MtPwv )WrmY)wdDX(M_`^l887٫bF&/"(  v}*ReI #&Tvj "1w'Xn=o_\v^,ҍD#gmh2z ^&VcA js\4_R=z(6~Iuؽ0C}~=6ÐQh,vu-D5c,iaZe0SRi1袧PahFA'm).v #mx# -/ýoBH'B PU68²KX*8%fnS  Qs\wlKV:i$boN}bԀlg+rU65J&c2oМ%ȳFk$4($1b"ϨF:˴ocKG@4WdHzGFEQɭ<j&P[Ehrp]6yiԖCɪ̻Η9B2U B #;c+F-fq5%ZJD N\\oʜƁ5'S%WɓlHcRLH^Lد]%Q*ƙBLB˦*poPaOU]it̲oNs0x5IXy/E,팒 `л4X]$f W ʘˊ|tfGK8BLSApn!M42_^rj|jp\=Ę=@Ss,drXV?% 7[ -h7:B"‘lQp dV3$v 2lA^ŀ$R4:(O\Zr@pfKy! Oan93Q.墎ٵi.~B`;s(*[$%FBK:$&U+ FFI[I fa5I](BRtv 8')N<U.,u(j^5(ΐcae@Fۛbpz 'eh4x]m96W1?e{F d#\,$eS 8`!CQ(4$u<#>D¹kd[10i̋ yaiWRbF]J`#mX鞿bfn@pK,n'?Ħ(DM57!k@]sq~T5(\t"} 3-m:d蝪D0!zG&$ƕ[ʪV\gv:owP\ufY[̪<8e@wఢހ+5w෼΀οk6~JBa?{r_ tnӵ.S\n/"">ߑF&|ȑ? /PPs?ۜ*☪zK>/v>\|E3l1a? }{7Ȇdh`o`;U{5YoUamsDGco kMl@rJ=R^Lr ܞ$Z^m ۠\j-Q֝GLU|,"LvNks gOqc,szxdK۩;ÿg׾Vô~dbfܙw, sRI-)K5Kp9gL,t9]'p$09 € c]'tz4'Nڸvk7S|Õ*5># h 'U6 ځ81u@;tΈ3,OlVҰ:Jwwo^O,67b-8Zz}OF"1Wc$[b ƃOx+6R[-T6@Kpk]/+׋q F悡8&0Ⱥ.ε&cLokFC@ X j>b q&PRHߢJ9JW "DIfnA^܎n#&rG-tCl0 ["#:1՝gpmɩl F}N_|³i_+2Б{QNf/ABZJ. ˵7`+g+uYzvh ]do.#:QOV'u_˧oK3 " @7şJ>a:|Zed%u."=/ބ/(\"}7ȵq@ MT@W\hVjX>9 :J1(rĪL1(VK{b]B'xj= ?oW;8OǼH -=epk2/<ŞFHf8#F|3nو\6Ǒ 9n\Ƒ 7P6ʺdGsV#@A }eLse^- rK6a&Y}@_lpm@:# }eCZuHG6"#zG6p l$xOnmrps+XL7kyBƖ4>'Uj w=Ҳ_x?`q 1?><=plu~38K>owth)q j,d@FOJ]oo U16HiȣyG2̆u+ ;a'@5JofNP@um Ex 0'mT ,Fef% +BMg OkC;j"سp{9M}NdRՙu[h+['|z@% Z9pxH hrirլ$maN["(s@}#H~1Z@㔋bխ/_T8I!m'Xv%GHjܒ⨼$ j]ډ;SPQ6Zi\@AUnzm ח 5|$+Cj3s|HKIv TYd]n:6kN)Eߏ$NU7r o^Rt6ŃXzϡ/7jTV8L]a1[ZD][D6GŘ'83*1g^>J.k*s\yԡ%[W^L"29Nz𱑢ޒfYyxL?s2܊`̥3:Kn ~ނ`n\5-E J,#h zkvju„Yp/2XrN$G"3C\!ka񀼹puP/$Ldz5үoywt+aAuDX>)J*˃>͒/t;H= i?|yV!-q_ A2+*kRGGZI7꾌Oc$[;lDKMk$HCdԵbq!$ N `07SY?^9?8O|XYս;q| UcWY6$=WoU%M̱699}9`GɕAʔDhc*"c%J#)MA%>(y0T@/1 .8[oYypi~6%MԵIoDxK4gI??Q}yS;&TQvF"FXo(߬$KxE#d`M}GbD}P?3r#\%PK!@YV"dܽ'OvH}.Ѐ'y8OZdn$M ٲ:X<(w -(k2pZ4֎ǣ tw<<7KpԒ~P=0p' jVM%M HkW2%qKU/&r7, o_¥VeqLmCU{Mb5ARNq}8QWP8}՝t]er79fx!6b DG3;xi<վMA&9>.?aV 7 QZUKy v۟*[ Dp@Twl38z[@da#ۧ9Ft˕UMo5$}mtQ]bf"PiT?l(7>kVj[5E}0pv8NibbrDWm+ p̟Aj}Ǯ(ᶽ0ep!LStbetiաw$~H:/:C]+]m= 6N ǵdoreHXT3c8sl3HO!şƉ>ئ]VNJjl$I/*|}S~XIdyg#KGh Ndh_:@ÙLc4pm[[8ZdR4uD]ʾz]fM HZAѳ/$q ҏ Sepp4ÁLrcS}ճA}fܻtg/Y^13f o.f&͍6,?`"ia[>*%lVmZOۓmZL]I$^d{dWmy@}ؖp'l `-`[_;vP0HR=z&1)A_]Eb1$>$A>8]NKpS6bгm&8 ^5-@7uH18\,8kC-z נmtA{įn~~,2bA9Zn^M8JAib^|Fϊsi- / *>_ [R< 6n|.#g&T>>P&clɞq'<[?a2=(Jt1s0;'Qb88v4"5%Rk@CβIt=ôqXՠT犍/j N[ ، . 7 G*0^Ux/*;`#_³r$ˤ!wqEbJB2QQ}RPUE^bjojO[/zD?UɎ9E_ [esH/!)UA,K"Ů&}J[m -HW-'<5[Т@iN0rHTլܑnnqp-Mn<˛_pn;!֭/-󕺡k]}7_6VXٰ,wL)X 5{T"|y7n+'EOs2qۑOQՒRkCoaR1 F&/uP ,2ʭ df$Qbs3'饩'YJzR6QY)<탣QϾ Ρ2h$e]=j/ uZ̅2lޭ|*ǵwZCAa2mTV[k~X;Y1ڤ?PgZK_ 7/4#v&c%-Gw)>RQC<_pYъv)wCg|q?v{L^ %4{{gK4ahyz`_S ጊ˖}8hpn20$e$e#qR:mǓn:Ԓ2dd` b3 I9Lj:O|%wa&ytjAZ9>A8}`ϸsڵR[OL($4j;y O"yб`RVv].ѡ"4'e_>KyJ)R$2aaNh,FJFѶu=A&Ȝ_{\VD7q7UR?ٿ+e(6E~2 ((3ː.ujNj%K~RK'tj=EI&",c`fr)`J.l\֟f]0q.NUD/i7ƋYf#*;bњyc\l-eKh2U$WjA&GhUl)\a拉zj:EAUwjEE2؞ /1ZH:wpX;^RbS-UҜu.S7Lt?X\>A8v&<Î%Y|ʳ;0V!Zf߯5" M||!kк?&:~?ar㱟o&ڼ/|1} @$kwŃid#BFNvq\?0?:D>i퓒clLJ[},?)%/UxzWS=:MlҏETl"Q6ezqƤ=㑞-P[sj0 M#]S57) E N Yj@A,SeeCI%-`qUTw|9AD SY \o@S<-Hf7nwdS {[Y{&| h ~LHuq AƓ|ȲE4l I"wF$2oSrLH,z̪ѾR i$IYSZbfw_yG] {]?t5'yODn UavH WإiZ,,_3SX:2cAgIqHUafb SL *G^^;!O1 Q8x(P.T;VM3X>cbVOxk? s I/Rb e f*܋QMT;xXz&Uc>to2BUYB:RdQv낐XRaqU)(G cMӼzG\]Hm%?SZ+ʊ&PJC·Ow-UVh_UA@ TJ.z* BP]H=US0q^5uλb*~8Z Ӈ:T&)ģ+e($|QS#\)ªG?O}g̉O!(!G@,a[ϜA|AX*taMY*l&$Ad @!X9FCD]c]{ :Mk/Y_J?X4ς.fM lh`1[4J&Rhk>IRvxA\xWafTF[Q}IzfMSU(Jnl[C)]쥓]ݣ".+-֚v=NF{'몶ê׋;C%hE;сm;z/||셾8϶45ʾ!Ԓegd gJ UQ~+V U/\Kv`Ր$x$1A)oKCmz Ӧ2}a;윸\-^ y0nICr`S)|'+B梨 8D$ݚ" @IgP߲p.?C /X-I.|1ԤM(›;4 tf.,aέ NE5rx9Pb[yWTo.*M/zh"({Q#9zgΔ`<uM1yhQ l-^Z2G-ׁV z*:otf oE$ TZJuMR]<]!_s"8UA0My[G+ֺ K2&'KL=B*U6I i_q snelX7-Qu {Y `>X^Ԭƪt9~.7 y3^ix+Yl*UVk mKii[*OBf۴BSC2 (l^[RfV&)2Y,r,AAd%8YcnZ07u-pB 57N -P./5z-+a.r-a^UZ^.LhRh .|B #'mcX"+tPҼ, ]gi}謹Qg3*ߣ\* X;TO]ea*K Le]eC*Qor*K;TWe)+TCeEm2KL! `>얮V,!6ݕY>_ 2{d CB2%YG PV?FȬ-d.4Y0κ}MgvG)K_uuh|ksU^ڹYD 'qZAi$+&8{ٔ<'UKX{t{<V1s:#֭5}1Rл2~O t\ԁS?n]>p_xۛ(*˼3lt]do(?ay;(E}Pm4p+qauYUw`#YGtĉXPƝ{ڂ4e]bunUl lIIMS;;#}#A\Muf>aё'ƋR73W>ldo3!%<+ύev-XgiHf^ĥx"p&lݳ-{+&t{׳ZL+o~, t:`h|q73J?:ƼhpckkEzڳ4@G\gm,?>I_Ꚇ%\Kk!Ε{[sbwO$yGe[B׉4Ҥ 61/McHehE*qo^]z>D)+d6 <؍C5KVeu^ƃ.BѣniٰY1c9X3hvmoyYGUYR?Oh}IsXfsba*yofaQDH]17x q2%8Zx6o(4'kݤL8|ő4_gvuEA"gT`)44;c͵lAf"7I 0-cؗS7=kt^YظYeZ_ƶAl{zlOÎ:\'yh:={4iڗ:?ȥgRR:aB;ՓBȬk,,1\3H#tDN^"%Y|xοYSyd˝PFDViRYcFdEt 쑥/{D-7ՕY<ъXyUw4}Y r-PSVl9tҗ3 4ntq"xq;v^1^mŅTxtaFDhI].}9#n][yzTXxyFy-‹T /p^G^;^xxi~Ë)^p5.9I<ù-U7oܲ#lti|HN8[]mvszрW>SX-ES whzͬ,,"Z)%*!TGv6{ٝqnA-xHjjˉwiNǾIz&?$ɬ%IYx6 lgOThi'EMMj;\2]_?$Ǯu ]@2#jacH*A ("#Da0hi[?, m06Ā|}o{P98W=c.MGc~ھ0IF=I+8` #(nMEc i|sTJ eZ=2~93vy0%Hy0Ն'*hc‰Irb= ܌]+n8EUC-τ|'˩Z (pUި&0ڔb3\]萕H -ծ|{6b5h2@;:8h:VÓ%Wv$n= YeEgDm*Vgg "q\ch^t" U2mH*3G %IatjZPe"{~ X¼KWv1*rQl#'p+Q}(3vsiT 8-S-1_j*_4(TbE[ :zĘۖ$xmw-bt@0.5X ir R]|e#!/ s wP@Yvv{y!޿|~~&z&\ǂBMYPiYC-_ZڇZrmTFxj[JT~1Pp P5q-@c[.$Ӊy\nubr -9RIGRKsPc/nv5# @nQlEױcB}]!ĸk\[euTۉҊ808U:cȎ"\xK 'G<:.$6 GZrkW;R7*5'kW*:v oNX%N"5r4wb)K{'X%E)G05T8MJ:%~AbFp׌r=kܘYXxւkidJ zDulf}MR 5;DӰ$Wl/|CK>PlܢUZe_л4u J=hYѢ`9UO&u9v" !V.p%A>}Nu,N3##/O7|o>}9g#*ףB= y]<+^ZT k:%\Ǻezߚ #nwm[&M;"xVBt;q[ ~<}i7| g!톺e]0w_©UI蒇P8b"'FZ,˼ɨb[N*^Ogm֭r_Sb 6b>xkͺ4Ͷt#gr9#xl?gA%HuG̉Vo͡#eb4% j*H"ނ|§*&ucldYu7IQ謸")Lx(2X3WziXD^$q1moZ aZ~cŅYy\cF 19(ͩq,ecnwz9Iwury$mH5sIcKu`FcbmG {/#xgZS>Պ NZP%Gei ]~Ɍc{f@ujd[W `M5뇁7<_',x9a_ʼ]S_ؘ'?RϣA:%`C&sVQ¤ʌ ?~#$x։*C RՉA?=oϨ"0ϡ!\zj|f*CeJ xY*,\J?xw?^_&TF(כeNB>t,|'+fu$!)pdvPαHM0)0r7fէ>-dUE+jL;#پ FYJp;Lj?:ۙ"rK&+84sBX]%DnEZ J ~;F:;k/Q.v& B" AaW% rZv:@#[q#5Mڭ@{Lm(fmdI__E[ͷ3~(>%iFTq4oo?c~_qvfM3qLrq? iBk 9w5.2_zm`G@k ‰i%]=x)}$|YY8V1q5D7 4WN[UD \q_sJj *zMؑMn( {[$2#5ՅRn)[,];ķ23z "ǸU gЗn{z͞lI4OVi0h5jvAe-k *",,|lv3XItzcs)r'yd./8<_ڽ.39$ˍw]zF:Z\Qb0P5f% 05CmG޹+qu" ;6,ՄF[NK4eFe=6-ƍؖjګQ! g͒reG"1_Pb_#ZYr?fNZ]P1ɳDR-@("3 $`zdvĵ c*YW4M*iq3([0c:Ur[2Ԃ X\q/wg%WJ.9B zS KTtJq[ה!_.K[fGVzm[3$SD21-]^\1wI*A|(*ZM;Kw8D<}-ԵRrTGMM5Eʅvcכ(JwEIB([Fib4\ɫM>Q#lȃNa3gTWC^Q~iv1k TQ]Ȋ| =,ؠ0@ iU&}SjjbPK6_KvjQW[HioٽKܴE@Y٦y^Y ) ~X톱7)(w'`V><ws\$w]oxx񎷎"v+\x8H>VRfͭJ6n 7,n- RUtXA7Wȵy*K-*Qw7E⹬jQ|fr{v ICdt Je. :xtct:qbsFE|elȃA4cʱcaXSi_ā}tu$Q$@Z-mYRjtf3XEg/x?,Ua"ԶِWTX⬚Uo%|_ 똧[O޲?JwMN{tW&&mX~r/f toĤLIIILP+/4$H-4иDahuxK<.'RoҾLmń'QC=ޏZ0i{ĥ[Ĥ{)&mT"qV 6 9^6 |4@ADD :(#+VNStVN)XDWiz6˾t#4A;gtXT !ґ/+tGɗNe:mhi.V)Cw ^ObO#R.* BmH]|=5^J5ZE$Eqm]B SapI0 QjSgpjGRj@dPj=FPjh4UAj>@]m/.Xn F W< R9i.DKJMQ0g'] 55|@*>͂tуN_b ӃNC.]ixZ~Ńi,%: > t7:Gw+G3+>E_>}]t5 - 0@fFRZcsebMY̧_{ȞbYݛ-XIfaz@3tdl!½ &7C+tuM"&Q$ CK.%⩀x d>KƂ-; +a(@`jVgg.쭊hh[( DR5`rS9\[YXh%bq/*x S$V]UQ 5'կ)HiБ%r 9z[䖦 P<ԏ[{^OKh1e,mFLo6k:[ƨ`؆8f/@~^d8ubREPSl)d:!Fh;B]*ڛ+s!|C.>m &p"X4;ێV?ۍuc{.T dC"<1R*k@G8`91°;0Jʕ<*u=B>p8ƴ<ɷ(Ya75+ μ~rmqm \PIŰĭehg(8Q |')ihkᝩ:> |x83QF$|0S}BPi00rփ5œBE.iJ"~DP S*m3`&go35nDܸ=-Uߩm,)g.M;о$4< OƠ*j 2ykߔKt6nLPY- g[=eZ|+˹hM. RIR@;']'0sV$֪6)gnu;j?td&UmLelp-E|M @]r0̔ZY+ 2ejR|t_Yf6<)d+C2G^EŇJ[cI: X$ԝX;ݴYD.UHz_ R'3],h>4X*OKҘLKv}Pŵ_MXH8zs,͒^( kaBR%w~: kYشE 8yӲt;º9mQԟմ95ELWf{R&KO!e' g8MȎ_-*;)*JeLhԆBA~ѾD1GC I dցsc+$"hƐSU962R.vx T9Rw2 ~ ˟/Ukj7gUaa@k0bE[)Qt? Wa3ڹx~$+FԹW^( ^L^x6`acx'\#'Ѵ?R)W*:kX&ĊJ͟[H4uVq5c|MŚ 7UI+-3ؐѲ*:Z1kdIj xgȘ=gе *[ 3z qrϟ@9©يAiBL}V|8'7x[w|w{Vom*/qzaC(Ͻo6\w>^S&p0N;yuԧzbDS Oϲziާ$|:TG\mnc0;@qǑ/nÛM, zΎq;YTj;zYEΧezfҚ.rSF%BiiqC}G[EeV}-|q}h.3XSw{u5爆Dִ?>5Ue;9PKO8N\o O {kxOVO 9lJouLSrg6ƒ&أ?q_g zqVP:2etepIH@%[d؃F* u*FTXW^gbo[f6zoQYڝuZцA+ SiA:P>[AKӢlZwi>.NVGsIUୟl}ton3zZݧc6Y:tÚ|O_^I9e=b?gb[M{ߟI$;\K1 㑆bAC3":f ! $`+>^a{F4K>-^5|Ә}70<|?S]CNpg}qlf<ʟ}AWEryamDVOF!⨘). Zױׇ`/4k l]x3IGV4Tl@l_Lu p%/hfC+ Q Wuj:A4Ub.V9blʍ"J4tzb[ځP4Aa.ewryU2 9nX3o!%͹6BjMbU'"e~-ߡ[? glcII L7?o~Znp<ݾφ7gh%IA;'#9I(=pc N.L3EyNfzzaKݤCKmcY~s@;maL2M.x\/.v*FeVti-j}?5D`s=+bۧJ3,-0}kaFmz1|ʥnd"<J=#r Rl~V{ or)D%eH|՝>0 ˞3s'H0ytJ] 4gy%z^qZ@k0;WY/p(G^y@e,@A)z?Ui>E_`S:O׫NIn$OE cF"^E ֚QF{cFN:!RqM@n:a*U_@g(O|Oy RM jԴ(x[Gdm1uhߢ{ZQ4M60e۪?eszb{VȠa!z4EtQ هd=Ll8(\v)ayו~~K"p?-8Iy}Q~fRj4VƉ̜O 㼨msu1+qw$/հ][b!/+ds*/&S'2?X?axFMLiYx8NKHNIr9m-gFPN.4f̅$u9"%b6qC4i|(IN[섒]LNʖ}itMKNc`Yjh_{8brХ->@]nxjeb^ˡW  K,om{ؠ/D#7}ٶ.)Ϲr{Kjr癙t6p`c#A4y .Qч*c 0,rU zY]xҒ[W31 mBk4{u 1Q~ ^n\Q]Ti eIJh4ruXU4?6 ֹqҦC J_Gpp#*<񷏠K@8є-j I[ʏ8`##pT%0-x $ƖC'=ce"U9(6? 6wfc)M6rv U|yP//=@yz&!CG:( kвi*Avx:)Zc;6u .2A@ִPld`oghE&T&AJSGh0vpu Х'̧b;r</{ʽ@"ʅL.8rk L\!ChrfVH&G5SLkPoB'0Pnjz_T+B 0-}9fKB>9{BB &] ۮT 72B)z$@Io!;5sh I$=NeHKz8'=M'\UkT=z\v1T fs)y/̗f:moӁi[8D ۵gBX TM7¯<|Lɕ\8u&i䤟cfz {F@6%roLʩ(DŨY 1Q̗$Sj(p<&,‰tX@_ܕdc8bȘ6Ѡ ! j,pw{ݱ|@;s>辈uA\-o{hgaySU‡B צ޻1":ȫՁO)X|zg:Դ{YZ/nZf@n_E/-蟿 /4P ݒDBsӉ=cjsH;6u#>70SX%Ikk;Т]p X dGʃO>=iKRp gF/b%DS[|cM[mX`N7sw Obݡ񡯊xu'd4i1vJuce4;$9ڲ} ` Hu)ZCnCy,ml^mki?y(wy-(b欓 +6JI<[n`,~ls{뇮XUc ֨?Pgşʣ͗Ň͗kz ?z[%T_`͖/U]eߟ@q N,>ti',{9g{[Q 7فz7.WT#O,-P_]PNvڿGcppqcKճם66R@$CZ 21{ h6T hY~`(jm5VmMIx0eqVU2I  ^&9"B\[u-Alu45>0n;l(uVoج)Ukk4=c+9ƾ`hQU L^ERƬzWhăV}pzk@iװ@uhWV]1MSuh]:_сh8.+UBBA^R/-}QI`/U-+"Qy (,ީ vd׏h(l.(VB0u.y;pXk'_[3o)SujCjh\˵ K$Q~W-@A2 evk^emy%(yslqpr@P ]no''v1׸Wg/wVvuQ,LAx !a*k{ +Ϟ H&>BhtWRrcT)JZq^]uq/b# ;I@xڥ$V햛L4GoS? {Rr͚^D pFvC[zaNLaE *%wMTW=l\F.[N>oXm]uV]8@u3E98u--j{3u_HUk<(W1篪? vNt8whFTXV\##u*=TTe%8.,'[B2n{ h{@*f'GEb?5ٶp2ۺ"S\9YNKjݮl r9߈W$DZ㭣uy0HN̏7*}O]7\ xWX(OrA*h Ks0b}7{W5{߶YcbL* Ux~,e,o3DvAf ţyC'U6[kv@(OPJSY/x^*Xh%:Z_ TKh=09 I%52b'Y#s< ȇ6`DHoqdx̤R^#AEV"}! r>;(Xboo^7XNiџ7DNBp@4u0с`O`8SuqXqx%SQ=6ޣoM4uq{QM?;͸z*I pw%G,SsѼ?ú/-?_A6cƐUf ܹK\<ߘ޿1|B9(of/^*un黉jG/S[Y7A29وX$2p[I vK n۱E_߳ӏv#4Ѧo泃v}~O ޷խU'o|r6y'{'a\1=Q[t ӿ !ozfcn#dțѝ.ɷxr7=3u*Iq\l~"G6&X4`fBCZ}te\qAUV{#?VN$d` \ T{ 0.WE?"6ډ+NQOoB B4ՃEEaTmd^~,meڍx9qOS xG8?6n"sjUc VN[&H;mJ%NUs* =P,o:vY]S;Za)۾t[8 x05j*PMH|k-.~]Z/;J)aǞ0Ǧ' f~VW1n\9sLs@ 3r9vʙ'(֛44^M?f$E4=i5pF3@'hʹ)qv2Ue 6_}&a_kvzV=a\`q@Cw$q_1Dq#tgb!ђ|$bI`k"Ժc@{F7@C޷FBgNghi?&3@':0zm1u]}80eLr.{WK=XkKӈn}ZY-8o3y?U5iU"Qg7Tw:#z@a1۔G?`UbȢ_49\M !rG0쭤ucw"QG6{4N0{0;m7Ǫ;FJM\!5@m%IgWR\cOX-֊w(+wgڭ ]x¬1Ǔy@-T$EqQ\ Ȗz+v7?akmb_E+8'oׁ;پOgwm [Cb@oUpA-%0bS؄׳*TL0AZ*mW_ {UuZv7[cC1 <,bMD! 5!{iMebVlf0{("ytiwh$,_3wjM.xe?{~͞O)rihڌ5|/-iMʌε>gu22nʼ/ 8.q]wrq8.mvx 1EFd72Xl^mc,tɇ V嵌sA[[:SPV]Oy|~o]6ϮT'"cVA >]xT"}}$X}\/KKSov*Q[-~zNQ58(QbK9TÿP;Ȋ;Ǹk[?eFg+v2"ݼiӼEcN_5H;/*[b:q˪e0(#Brt2X7vF`4\UYk 6ob#JjhD K=8"bIE1-; pyO}Yв:;;Veg !G~PggSlF4y$>y]. EЏ{^-? .V5Y.`#B&4t`EԦbҚcC(0@i+[jWc9~%/mv޺c[q3TG_ޡuvL#)`0iUg^Y͕K}$]4</?L[fESf)oP^g;ܙ"&Vf٫/Zukpҷ^1&sECu 3 `aUl‹dNP= <̤ʱ|#~Sn<6ZĿUws?BcDѢ&׽cTC_4Z.Oǯ#c))li!Juyo0Z:OjHO?HGN,Uih៳uk =i7y (B=52O)z1Re3:]DԦ_F\1r=lfQHg[;LFs2K[>C Tɂ9E0(v(66#.W3f9Xe7'U V8s5xcF༱͉og;[^ڞpvXOv'*rw/Vh UF:.o 3̥|y8P]Ld 2Hq09s0<宱h!pC_|+m{{;I,Zt2'޵ UC18A|8J=G̼."g:PpV l8Á{?ؿvI}bm;ͧ :4v쟷͕*7?aLt E)UFD#1oB 6LYicvtsӖ {W(4^۾|h<24SgWJW#Y^iuI?n}+Ӊ]}Dn3-:auatAGA]v v8Ouo/HipNDYFkR K]@~@XPX msi2ekhG9q?5NNw_eCBG`|`b?DnqS1yX))gu y2/*a:qjɖ,7s>Sdz|@@V'*PJ!-Sjr5U${srw]3hFs.8+&ilMZ_~V\GLk"մQ?]k86\lj^ʢ5xn( qn( s<@:krkobvT$6T!:еr%RI_ 5CwzzaM`\#O{!\Kxpz4|*U/B~/h5  xVR15"*P}o2mrV#SC=*TJ:Hj-=|^Zz+Vcw/VEIhL+Vt/V_r( h FxhQOYQ~ mHdC`%ۤZ9jeU+eybTZNj0jW0HbGbt̸[/u{:R][O7L9_C#ַk74lNo:=VFW1VF#~i4HW*No~xPKP{l >nݗv6éY?3XY$mREyКȥۯpg[TFnQڈck#xj##4ގ¿4K3&v 5cvcҝN^wn X{K~I`4+Kv9S_Z)il* >Hս!Z[$HvlG }[HHKvlA+7QRX1k1ڙ͈K(8 |1 vIZ#xPrSt-n= km{[|sOw15K,o>٠h *rCUOҢ1Jkڕ@!"ipyx\;tEgID;tj$ˏ^&ͩJ |_Ca|h;c>[^p`_? 5h8grn+^XV++ۯ!umsOz=Jċ=} C,fȝ'X3|pHb>EJok #bVse/p> +;m2KqtC XZ%EXRpyOMipfUJWVۙ#V)12vkZTC,B =7x{ 8rqRm^_v"җ|YOK$‚qљcD ϒ0G6ZcХ^%X?m?:+0ҽcc@EDxbh(fj LwAIf!u/ULZPN/]>F_Sĝ?>: f[۠^+yvD[Uvt ŨnV3Z+PMQv^A$n.cn1̞yRwm +*#6lg1l= RDopNpEjжm,'aE,a~,'x.zlR ԑ9ֳ&vw8Zv\bԁ~qc~O㊽jz, Ulڬ1.8 gynAZ Y1c[O "Oq!`-[+u~E.ѱ8o%\{q6]LY1 i K1tKNq4ۇMm>WB*~z^zo9:iCgqVFGɣFͧS׵컓`ı0 8/ċW7jPXld |1g-J,\'$eᆋug5t,$-RוR,D)Aeu GPʓ)mhHG(կd35hahHd2,ןvFW YCqnzEC #rN9%%Bzi=CtaF#U _iO@hvh7i QDLgu2[9U ͫL=ܲf88 ]7qUF)G &A™/C֍|!gu MWAsiC;.L*8_ bv3|İDTuMo¥ћwmO*Zn 2;~"&?$ZC.f0UƞP3Hnm2]y:g '=wxs'6pNG(UO2rEaܚק~wJۍ=\Y:W5@yYwQ1 RGC-p֘y݆HG-3(zRB 'γ[ T[[nPnaw a[]|9j -L.7(R9T3ߥd C*KJ.!'ׄ\я*~5A)'ޟa|pڬiGy/ah1KJhBm۰ippC3Jrq>O 4K3"suEE=(H+&> <aZekW~U4V@ĄA!o-'S_@iP'Շ'4moY=|Wm -GG}'PVǦ_#]e7~;KWeWP%{7?ű%o˜sNi@7nAʼaЗIS&ITEDm~1 g^DI`k3IȒ*%.ٿ҆ލ c # Haz}~L"`^%|fgmmޗv WZG/ڧ葼kqE]d^p//j8rϯ qmfS@`/0ǻq&)XeΪw)ΤSBxHAI{tO~DSeA(@1.dr?R6MGߴ* [ ~M^[ʍy~ߏUٲN7J,S(p1F.+ uD8O#EM:G#oyږdG"LcQeЃuC4< r%Gvhl }#kF9`VǺ H('i䎊#,hyi0 gx"O^goY4;&I5ceUF5jmNH5$ipǙL &!`/t3JU>z¶gKz9Se848,TcګƖ,CG, X&a׷TO }ӣԽe:!(qu^ɤ.(աP7z \o'zY˖ t]C*JU0HaS&(nyсRhĠF0"Κ 7JvA-$|D5<4sf<n co _i~6/0!1 Bq=V xSP&o*mߧ19UU _b~*qjN4 :ܠh/AYJƹFK-YNJ ^}L_ܲնf(dVV-][\bHXhvpk?{e-QcLn(h|^jd 0d w|wt9qI(uyu]ֺ@.͝e:X@D9xkKZA{8mlոӊ֥O bntd&#"g~7?& yd["}=1e>H?6=hLUqsiuJ?K>85Wdkғ/\+HI+F>%7s$NH٩X10cZ|EC?p^n8ƒjn8J_ I<KWG!zr(o17&QJl8!r=Yv^Sfoz[h g{$Ҟ#ˈ1η!N&yA>+vف~Om!"YOI x$bxSu1RA 9idm͑"]$v'E )V:$b-L&8ecQ0LXd.72$c Cʴ_҃B`B& )֙.PN5 7biRB`R)7P'oؿH.~gJ;Xc2B| |=fd?KBw " 4;>q/f-P`̇\Ւ, oKV2;dc-3\?2@|=d N@RlI8:mq6#sa '_(7\{Σi$5MQ8"E +E 2pM 4 ReSpzN9E-p)LНIϓPI24dZck65;dv@,=U7HQ.wJO і_YM"&d)qՊŴ>""Mga'/?lr[%#Oz5N0w@+ "d-;IjKj'pմjZIWk;4 w1o3*jA{N|[|U fIwo{{Ml Ax@Iv'QlᜪWI|=BjvЮ`Cɍe%,Xh Юٗٹfoc抯zݴc^=fAglJ$ =)9Vx\&{Un1w1W>bbB[|b~,zf*eG'0OkݟlA8+FFzmӪoٽ|VF:4r[eDuouV;߄ -<O.5(U&h ~|>J/-ThB!&~, ܦ-!tC|5ِM>.Nw~"?@L=04!4qhiSa#K9iX9n.'"Qj/}"O )M0{&nIMC( 5 ǒϲCAnB)R\)X Hyy. t~ʻǑʄVF UCQcq:4"4Rs 2^jenOB}t.wG ^wkxQO} t1lFr|5be kIrf`7].;OW{f2A5XL }iGw)%ڍmjПMY.4TixW[:4VΨAqIb؃4C@HrF*!$~F>}.qVW+A9 ,Vvm>L!eQh`"4H?&'ʣQC}ZƓ<6f(ތM46dײ-e9VS$3@m RYO{%goުJ}Zq^\Vy%ːpl~qe+I^g[.$T|INdc zSE@EW"QU +Ws߻Į4.7\+b?>Fsn?Gc5z﷋"4:Ed쓷 zh[&{pj*cs0#xL 9!}{^`AP90d&8=y<6j)l /qJ J~9d"{[z J]7owN٭mn#rUS|Uu/vvVY)b׊YCct2{VMsU1<;%&c>,|zV?.[a.>-ߛWc7OcY.6+`H_|bPJo]]o )E17AL M(}}4|Ѿ<96P 0 OY:YU}'*]0-k^׶g+8kb3/Wt it^9FK+y#|C|ruK?}^o"a07p*\fCl|7N&Ӷyz9F`pn'1y|,6}c\J :!"Y NN?^1{oRjVb'w+]Z3?c3/th 6{p5*"VhꛉZWQn$%>9AW䃐u ma"ޥ< ^G6$Rqmg?CX}^V)'`e vA 1afa 64mKVʴ 5hűpA]7\M]ѡiin#\SC胒Qv3C`cHgNvSw|d6~a Wp;HDB;#&ܰط:/_fm/ԣ?7ezNk\dnAqI$;(`FGnSkr8y1} oKu$A1qCbَ:T>%g%jyR!UeɺkGَ?;f8$V*:'*"LQpJij{-Vzi.w9kHҐc+E1Ӗu$=StQW=:ZLVw{d2>b;%C%Ub+wIQ޺ K?r-pG[JBGt\ Z*׃YG3d?ghGS0qG;r+S,qJ'_͔#zM\F ǡZ:'ۭšKb+C0  :ʦ0Da acu;_G0k[p&lۘtULܱ%UԫV_()u`HX?.ǟ,ˮ7*&A SXYAxūky1]fZT ]^]ʐZ{ Ԡ$N:OghXp@iV<2K="C9q957)m..kiig=9V*2׈loJς&l6p~Zh.Js#:G&`qU?¥snq]]1N.p_b9]6owO|W5€kKLCo(ۥΏ9Lno/dh:ږ m_c\%;u (j~r/7dk!АQe7]ݘq;C0O5"ǶN֚ oi9avu}h8#s(?! gOCCiԒ:. ]/H>ѴnRH2 9ЭYaw8¬|3ti~47i7mH:P:>1ز^4XK:]\=nyOϨ&d%ysA]tcOyΰs`E*=b\#(4r@T\Wؖ%#ESW7%3W۷&tQ#A7[F(sxTݚ-W\wKeO=ͪϯdAJ΢[B6ܾdMSwm)vͶ 6Fͤ56-ycةRűO\zGǘFeֽ`ƨY_[4~j Lԯa[}}cz UAwi7K<Xƃf9Z\~d9"ǹ>w: m^Ȣoml3ݦ@`S6JC~P3NNI>A1YvYU>\F%KT!BI MЂ;ŴW`\&:^ys)wJ -X{2;[' yK΀/=0=38j?CZ-9]0sb98e'"e9:=#4Ԯ“sd+y_/P)?Eږ7ZhN|w_|80h P3蒯frƇw92ukNB-%_ڥ6܈!a?`ൿx艋 牷4c8MxjNtmddue~z W^]' M5Ώ0%v.yDl: Fgb9SZ)&d46 i$z*9=1,U򇋾G+(}0ủ*'sEu=nF5rd\K֍jxcMѦ5| XoV5Uq5c}5(w 5FCv=NM΋9g0ۦH UM.D̖_|M퓖*GXc)@YX[;{u$jܦnO`sC#9;RcHf {jDsxfK5N^q4'wEEawKb,33<, X?G!HSaP|K[N>W֓Mf1rg*!0 %2thZ:~']彦Mnވnh:XGgW/BȐD+~Q3 r>1a$ vy-v,guZoTZZx7xZ M2"7 ZxOhZPS -fZ[ {CPJ: i=76+ҪC;?XNfBoP[^+JOr <.QͶLFo$Tpᝩ%Ǡj6M}ShCͿӎ:#%~Gd5Z+ ?0C#V]uvڪъk;m$1CzVpG,ül!S8.HV]Z3ubsq,%NC$0pvaWgaY0`w* RKmW80 n]@ GuSdt6XvG5ZL,{U]al캀'ߩ xL]Gl\Lƛ&Y_3{L|pWX{H?9Wh6}h^1'@7)sdryͤ]F "c{ğfQL^Gm4#+[W͕ͻJ&+.M({d`*'ih2(Au9ʫIeu06//(181Gκ/kʹ|%LK4_vF*YGyh V:+38>g\Gcho&RiɀYh|{U} vfy -2PGre2MԱRa2ze%3uY|'H_2Y lS[n$~j /1p]dұuG)/6fiC^Bq>W P+ꋍUd[4T,#ja4l\+Nj }nTA +_;β"!0@mc,L.0},n-~%ӓerAcZ*od)_4RԴ83 Q|TU6sߐj-Ld 673l9Ýtw7- M&knǬϨ&䋩?voeEq@_V.sX--*fg]xvjtZ{x$;^㬿5r-zjio8඄TFn{%4$)ƻ|A:oi7s$ݖl@Yo(/Li5H.onO_DCE~'Fi+qaH1 f{/J4uctܫAᾧ#%cGF 1  ҄bđ"HD+VM+W0yM)y7R)"xޥ!Fʰ#-.S%":)^PL29nrB{ ?hz(׳Pa=i5wdaʐF :1VS*d:1tbez`asO[Fo9-zco^}#]*[%ET&Wވ6n|0. B)\n1.~)~7,}/5W? ߾Ĥs_P[O!4'4ʲ8Iw>||Tp?#&ȩt''| YsЈ BЕȩnȉx\''G;EQ(歒ԑNN4iwGG詒Qj~;lQx:= zjM@H)FrQI&>h&ϰ ײ}lk{s㑩V|K$:lfq$^(r͠|'<׮(k%`*Vq1 := FQ*rͰWvwTk}IpMhe{9w$7R]R4CcjB-͂}4:̭Gl:i` BU&Z.m2Hͺ \.Ewhv]ç[M!I! Lc6b"*]Q{m1;G$_ ֹt S."otd; ^ֺL;D1 i>l:n}.b[A*iTr6=s־ڥd)eimM($쁤&٣BXo؍ d^갈")Rv*ؗR; !)Qf szv.렂jVA` b`Ji(Gsܕ==@&4ykDW%cCdr Tj /lцs.E͢ &VRZ9%+ܳrK*}]%]9bjf|"z \6Ūwd7 s4,'Ąs+"pc vE.1), 4f+ N R_x;ʙр檗Sп iоks~>+fs;@d$H#'*-:+;Q?"x,vvW#)枺K^ݥ_ʾgJ\צ}a K4,G$&pZKs_9Js\IԯıcS{xek8qbM/MCQĻ{iҊrF+_[L& J*qWf*xGi|¸ؒ~,saVM\Y6{xo@+.N-h+%+Q+B0Ԇao\0rH!p]w xɿv$1*fPV [{$^C6~og1_}#d qTf'o5Ai>o7o? 9C/$a;HrΩo=}Ҿ$kpB"/Hv#I%ށѪMLA^-<ŧ& n+T.v~=EV'ُ/4I6A߯f"צj*!3ɲQr\#ռĠn(& r6xZoS=,.:&ͿhDjP|Ri5Y&}R`(^G˗ٖ!}n7-yP?HБB8$'4eUu8\2ph PÅܷPn E o%wJ_QҵM{rcH>L;d[4w/c p|TqwGm@,o$\JQ/3F8/̔OT(JTFkb`i`#S)`% Bܬήc/2;Zv4=>T--i,XZM*Ä-cpcR~h{BB"q&^e>u"+몒< #' N`-cfgV:徥< b%:ʍFkiHQ#ܗن5SSI\|%' p'큾X!EI|eW`dW@.(مɬ\ٕ9Bk_iKh`cM2- (4wS(DFf%pUTHGLi40rX*Օ U<>؊CoZ1r% /!XBdhjz+h9HUl6@5nJ.tS TVH]I Y$YTIFwT:ITI}Twb1ͳ\ϼ"n sIhĽzȘ%Gnfy$nkO߉Aݻ %d1B ΅)TŖ ],!ūhG33UsY⼕^>v6hCXǍT.+6J:0 w*ܾ7Vvoj ^ zZz6$@c<`UϓRv7nP9JUy S: r~apOF5p op\N7=Jdۃ9JN);VF+XU<^3Rui$XsM)Loqэe^_xZj87렏!)%lm*,@2BE4$L)+2ܶ/^ cFye#$y(߁lx/"_aBfiкcd:)^AI pblCG4d"U 6j Rn' =SGk ٮP)?]u2 "%e[9HI(o+^K\<4bɍ)ȫBf b &6Έ&N*ɕ@ Qcy/RIj?g5T,ۯ*wL2 Ls$/3_̍2q(6ZQ \x&fѐăm_84{uݲ%.B z[Wi{1l LOC0W4ع`C+~|Ö?]܍cn- t[dq/rpnlƙ潎be ^fG V5-+F7FIbbgiȰܔƽcߜHBiKY; M(J貑b7 L%HŔip/U8"UWpϧ~3-S_d2qp&a!5z;4%:@ՄF@mpYd8aسrP 9 O@>pOpޓǷ&/2D8)|4~wɾMb Qn䅖.ۗ#4Dv߄10^؟H<[Kؙ^&j E/ >6pQٯv\)e56ߠ3/XL{!K)$=Hbn̎i"Mw+f i>64&n v\lULY4Ѥ瞆5;be-) %A{M8">lsD2YH`NQ[<4o%L[[Ԁj<|5_i/ 0ꑹ]C[A^fA-$KuZ"r)hH/?= ;;&[ڤiO#Fί&6[CY;tHRЗ8ɮFA?,F͎XbڑR׮9fmߡZLw+P`T,~qׂ ]DŽߵrSٜXUy@J| mF%6AXi=,w펙mO{aʚ6nYD.]SۼA4S^9Phi"V'lPw{:fYޔhy]ܷ T@ͪi,}z>C]Kxt#QsCNV;Ň[$_mOE# el@gE܋# [81bЬa /TS?X'gmQfgUҖZ=kg- XjrfC"k9]Yzߠ!&G:x j)4PnG75IҎLJ[}~њ5ǽ"qv&ߠ9C;tZ89ո3C?*&V@>Lsh94̎7e.yx 7VkӰ _;,Po%^QCdLɜں, YRԭ^ ԷP|D !C[ PrZCL\LXE [jVQWQBQ ,36 Ȧu2@ƫ#aV ЬˠE[:,? 5L>oݦH=|[_N"s6/&5Dneܟ(#oj>5QfD8h~b5A2$+83_SZNE"m}ꊃP 2 b*R: RR Q}|h5V!q RĘ*ҏY?> [wa?! :܍Ip͎T"փ0I Eo]aKɅmD(c_C,MAٽ0C4fo0PVIT U=x qXK +ul0[J»֊d++=NȓbԸp1?3mΰ/{-2i4˱G c?<ی Po/`Wl8^h8Gյg#x99 =6В>E/qUh>9"7[JQlL*}N!kj[qP<ݤWmO%fŝq8֌mbh81xS5/5Чi=*|hg2s${#X%ODK?Fٟ;# ߱Փʆ<r6*ɒ,FaW<6ȼ%@TVo<}ARR΃ws hB0o O׾c's:Ҹ%K#|ȥcU D-1 Xit3J=."4[}[TnD8,lZ:fI'>~~5WRlK/ 8.xVHU~iՙe_7qQeW⪈IG׶}iP7b@ '׽]34nL<^O5Λ>8pdfCLh{f"̗Aߙ/'ϗq\34d fKݠ$k}U&!FqD|M@3+CҬDLL394(@L8u%G\O1uKހ&- `a-^:2/zoj˽buAun!10yȞ?:f2G ϒj,0ȐQ VٴG`0 %1ΠDhfy9,[Yzrvj35a)a?bHaz̦h]lN@%W &Y$fXC+3O6A}8d/)o6fK [[R8s g Q8's+[ /xձ}BzlVf[j0w ~!2;fa( imM]\?kf:6d_-؇ osUYQo[a_m%X'UlYjVsz{լt{YX"NCnmNQW|3+tQH WFQ/kyՒb`+# g3c #w[V;Nsc_O|]Y-%fHc/uϛ_ҠnV ,g1gzDW߬g;^3kd[L?einFa^̅3,&>g,W1!Ȁۮ! ;)/_]=l p,wy~.0Pz[SdvAdL@ثoW;89qf03y8̐f,VN l^]Nթf~m!>ב޷VGuQ%9P*G}§?:P4w7ptegHfJ䢌!éb.u`STw~&7Jp1ybG+f'yF64ֶ.FJUķ?jZ7;Q$X)g6 oo:`~_{gS;G iqc2vbY(Q>ս`L;-s;zr.cOU3x x0؀eXxW XU:@t5xD0(܏MnZ7< E(jbN|[=OpkW%1 :g@`L+Mօre@O x|HQkfhqdJ6ߎn+dId/ܲQUмO[KWXe,xT\>K@oc+1xΝ$vXzt+Nbi'1QdjlRQ6K<*ofV51W{OhۤjֵI| kx+ (w!Ի1 XZz(NE{D .z')NZbg%,+J{:zC뾱 Sıh|Jo킪$;x=I]%ق6*@%3wջ A)H)Д )S DHX¾W&0R 8R@2@)N)Czǥ SQojHJ1֕0U/^UJ d!4AF/Oх)AdBJ)Õ%7|1vDqB& o$#T~ӄ Q'Ǩ)PLT2+(R9566~_]qSG?0hIHe(ߪjq-?T7+Ygqs(ElZ{B܏7\mo`e]oR~6=;XǙyI.Y`ح N$ Mv0S?x6a^&"jVtEHfDCI5P}ku=Fx-pbz3z_>?n cOC; ~@u̐b?8/5 05[o̊`AUl#Ǒmd8ZlX|^D h#;)MrhwdJF8_J2#$yzh6nl~.m4'+H$,chfkb2 kQf11НN8[pNjӞH#.Z2LQq~8orίJfpPqk2Т>3\OC8P''(Ցǥ (.M^ӰO"[%Yכe;q#VMOJ겤mؤT ,E $`æ&tN<&uw"q{0V~[qTpMΚA+cJa*b+:I)!KU<قȑ>~3r 0߃\ x%+X/ئl -D @k%Pa$eI[V*z[ =QoɅnx06zv |KmͭTpjXڼh(]}N 9fo. wI..\].)Z^.hv.EF\``Iօl/YZDu1l`9f{ KF?QmD^Ht*:KͰօo]>2y2=Fya.YH67/Xu qmo^-ּ%q6 K7_=Kaｺxu-UwR1P]GN0T~]Ev\E7RE˺&# G0Kjo1 *W~?|!TFVd^+s{B\,rhhFndxPG]y[ǡw :XŪ J(L+o3k]dF5dt{`%* Hqw` QӒ'Rly^p IZ"FA:?9 Oc.{AHpQ̿e_ч`$ k:"NyNrL4V' &+ϥ)1uL.SQ"9R`_UnR1 P#T\KV1z4'Uį z9!* $w= ) A-o>5A"ԉ;VLϦƳٮ>jٟC 8n2D럆tg"{2,}mWow3x M(@T8c? Gݦ?\b棬vey)% 88 R(GFƽhu/ wY̟}6oMf[e6Dڷjkl׌Q1Oiȏ5O͙=o6q(vg9s}*p+fHx1kSB4, \B/Y% ,iS[xr-0L>ѧ~Lּ1W1˅@ Q@_/yx;8vSbcOuX (w[ed_?#S|r79xRZ߰ĹAJ1C }7^uoyҫ1):8IWxjC!ęB,9a))7<W%% <4;aȬz7v[wI$% EIvἔBIJq~JJ;WHJ]R Z+a }e}5%QUSb agZc`;1Az0jL!L]FU"G vQ{$fErQ(lzpd^2 {U,W>O<P^}M E&A#$7>cl8>c~8ذx CcuyŷK70ʍ>>nt eQ}ܢ7I}nOqFTK /+OzD"5GȃؙQG9: |ꍺD?,yneW-=Uz'AGkbPZ,VYL 2)o͉a͌]bc ե(1K:# xAJ%$*9hf_jps aLݹe .mpeZw nC^©UUdۃsfF[|b/"K wouѹoJM1>n걬g4}aQDN2.V #eWic1E1q,mAeNeb $OXIF')0˻NrŲ>~7lv*. ;2}N算w9`5~w̹Yܛ~yͽDe 9z 6"SSyW~^BTteg)A]a`KydS޾й,蜲u|? Ti&qSJ_|BUˏ UlgiP諂6YzDyhe|`Mc-*yr@a. 'u_s9$[%8dHN<S%q~Y^<3dŢhgWbHw7+z]mð1. w7hm@4ز,H1pEm&"Dl>}5eMDUg?mafuƷ4  m պg7OVv_i/ sW9pו9G a u ~ԭ0y۬C\ӬF٣tEF5N ~_^[wת%CfK_N4#DP=fѥC5uK%=HV!Fj,}RpnW[;Zc ӠxgMp5ܷ֔'PVg#9Y>ng[a(㸩]&Q>beFʚe9Rɭm;pI_pjݐU᎗wֵMwf z~X]D=7,- 1ddL0Gw Wb KE[<(e-@d;;Pl{1NUksͣ%Ho*N%4@ ״ jFvl/fkF.{fq<0_<қ'v%laW>{}ؕsvj3]dwc4Nî] v 'J<R^aAjsETeP>E>J4^z;wr̹_gy^SM*86~'k3:wX=kğLJ:AϬ4'%S:F}41c_Z^@%L1@%ܽ)GT̀pg.ŗ faj\yIϤ̦c.mG#@aד(юI\Phz y.7aX-lp5s60%VhYlXmfePn rW6. L)c+6;WYd'Eag =ge8p'tcڗMZ܀w @ek}F/;̙ W0z/Sa'|zR4 ٖ-ͭMc͟x>>Fb`)A\0UE 6r""ӱ9fͳрq4Ͷ~, }D]ZX\jdI]ǽ@2TΜe .8QLh $9ۮXYH|BXPqHP[`&`ӷ޿CnKrH:茆Yw 1+g̸|*|gSm+j1JuOA%JҴ“x~} O8 ť," 0v=-شőj,@|4+4Kl]@XUQAJ̒ 9ѸdRb^~('zȴHgr}1Y\Lrj: ~PT:v O/ ?,e}dt.4TTHq͡6O@[0$f f `؋f-HtNLq)CS@| < IuCg "@j hMbwHǝkdY:_J ^qmkM}y6wMu)%qEB$4` jCM/\z*0bQJxu\yEphmjFܽBn6> wh˷Oۑ:2A|+r3C]̞|3u- R|&qd$0N]>uҦWBi`q6ʂ_U_-Eh 0 mJ;3lbj`"?Rtp] \ݹX 6i'6;bi+#Nu)O䨒 .mE @++VPÅ}v_zj#r,mb.>C~8A25hK$QL%SbS#Q׷U]adP.)+KQ{L~4maQ(VB`v}w~D,r7؎yt(إ-8͢QF3o{\O'h IAg f+iFq4vY~"iD8T5eyAߓ*~뭦\I J|@I3Drϸn <' K|/Բ[oqp¦ZaNu;6wj,Z9)3UCΨ "bmv/;yZV<1˱B_/gKa |Gp߮y8?_mD$헴/!B?F)I` Ixc2z>fڦr8ZV삖!W4 Ŧ<ҚDz[7ZaEŭ]7?XF2Krmd=V@dﷴ HVbg QC(PǸDC>fc I 'mF5- [ c2S˭iEzM@?\#+{>*aU6\m GiIJtSj=͟6 eWm |%vs$Z9zF071׸H˷CVdmG7% &S'I&sF:1[LbglXDf,Nhs̓B9"\dʊA[PƤזR ƹOkj*gWJ>OZ:1 "`Oa.d魑w4SF/UdJF,s&[?mFOK V7YƟs[Dhc,[W3PA~F8;P~塲'&{hnn|TfL1!-@I,t&|AH3I%rv&g6]Jjiu-Xb}*\qM+*Ce"`Mo*U$ID/d\T.uRIJ(HkUBN1c{*V@2$uJeLY%`!6V"t(V,.2eR`XڒW6\FIX}J*t(VIٶhyH'܂%ҔX*S廪 cAfn(rd~6usonaW7VAB4LmA@#b0.|Z9?9Dg(N-1}BZ @=o DskR\|Ts5{[oq9i6 mhF #h|BP]^s'E[I;xCZG E&hO gvz)^P /k$0ݦ|OZ?_kuŸM sX7ӌ @jS -a7֌&|X 'Dj`x!$(vEp7ym$)'!K9cH=cFb\?Smzn'zoB[)>k h~`]Q 4KRWEVsӨ#Q'_ 49Z}:PLş(xk%B^i >.iE I5QCAߓ*~뭦u>4Pl/324{oqK lK[o>\2kLZT !.F'/.]ؚ"RIβkAhw>%Qi:X57@z9ߦdq8(797(Que18λyẋHZ[S45wsoSwUa|_`D4Պ~ Dj}h9S'F6݃"]Grf3f O1ҮUs8,Ϋ8VLE@zlb}};>G-ZC>Cn"my5Thj%;X,f}qdT]9Yj]ώۄhpdsIiQ5)%JE@4zV" b8 s[b@nu߅nM V@` +7YP%e8ysذ,j$+sMZ7U8A`#|hDHjcU>JY L7q@TNw+&Ԣ^4Q|؉Mm$z^$ /yZ:.qﲒutirg.s69 ]kLWI-P_jB\<`q@/w:=Z|eM :d:].vM7סQ%tc.QG*ЀΤ/ i0KlWB7[xH.u!?d'7hfN:gTg4< br΍!c?gM[~3k=,EPU#y-wrÜ6Б:.?Jp{m&Ɯ8t*Fpvp c)U/DxsN[A͔P*a(D06wqr׬GOA2vcq1/ƑBJwS 'LYUMtՔ-|x!#ٹJdTv: {&im3ۚ}:>'oؚ'6Ʃ=k{V@y3>)vo>!ۗ9 QOYux<(jy_G8kU؆3Z|ko\ )ojb3J280pXH_&~ w󑍣Pj:X6_Hc(89p47[ %ߝ=bl_Y;:' xa֑*̾;dbV|mkx j*,m08I¨$4!8iUH4SGU _] a0I WNDI "9kҍdh6R4v#]j౺5ɭQ^˼%~}Q-z5|u(@ Ϯ~ kfFPE9oVD--T:t2Y[|UOVEf*N{=BX\ PK"@Ͻ`vM_`雿?A+"g*F O|FxGiF([Zxp+4V ,%G B6B`бOJLNLe{2R^2a>VMz_d9rxd<{Ɲ,4mgz_`M?Ƶyx&I㞉f\3 *q[+?Ѯ8i$vQ=v b7jvp;c :6qq _(ڕcj,'HcʭH_`P8mN(P?4KMhY3J}Ŧs8# '/q,5ehZY6RId냳z*,MpRk VZR%"x (bJEj'ELBe-U=]+!U/4糐Z 'uۢtQkDUoW6 H8ĐڨKE>+g|/4hF7X*=3>YN0Ӊ.i4Id:YYv2o[t-N+#Z%mާx Q~p#+a=+o.L)%]VG H!ع +E\iRP}!(^b{\|>H#.i׋Q$M )g>- *?|-gZhԾmިɭQ,u2Vd4zG mC@OW~/ܲN6 qzÓ ʢBڹ!V]Ƿpyu9骠]\^Hⵋ!L_dOYQpA*^"6ģTP]h`lk1 M8EFCqZMxƏuM_||u5y"FW^){O|M_󍔸;ot-m/05$s|CR:,o麳QGҨ _<>w*uX<>w94EÔDrmPn⃍e-GO;"Mz 1+*^b/A_C{S1_$?n?8 F8MbL;~Z66>V1y阁`GTK(선7Y1g1`c8?U:%.vv>ϫQ=4nV3:Ӽ$~1pI } İz+wXh "tӈm?]e ӥju&E+W=$! TO$Wu5]#3^fFRށ`R3΍)f"p$# ֫0%aR4._1w:qwIeDv{ w/58F"~Ɔ o+I~QKaקOj#(؜G:<2΅dCX44yd/)ٞ3ZWB6ZnA`yUjl 3t  ridŜ̽ygT讘Hh]vv&ozUIE&׻1$Vy$"T# 3 {~緍(e(;''7kRp-ʟ%\ >GKxLE\.d܅8%VܕmK&i5g%FkS Uz9=/`q!ԩ]k՞HmP,RjNH$iHplc/uM%A.ZR<{hjb`85;d- ;'"BLj{ 3]_m8 S^>~>m{) fn(;j4 #a{抱FCaRh0I(POE MN@olơ[J!™I89W)F#m:q'>y&G1 Mk &BhH{M_J%ygr}]84L#7 Ɇ;->s=!?nq7cHgeyA 1e JtHFi=%b[Bל-~ci0|` SXe*PAκcmǗx|C(uɛ|=e+ 0/]j*ftz{Tb5An|s5Y}EqAT񔰛J~Î;Aq)WMBh+^RЕף!aev:gj jY+n{$5~l(|6dL3E{:MOtng·N*15C꺙4Kܮeo J[neVUc:ޢ(]KA G 3e֦KpTbYEcϖN}~s[4qɾWn:2ԭ9r~bN}gAۋ _av\+_,;xJ;㥶4ٰ4mKMdLsųa~_}dj³lu-9-E:7~fc_˛C_(Wg1~O c"s昉q9xǢq<z*  !}& Qf0@N%ߺwcRHւZ>lrDUHI-LEp"R_Mo": \W+zh4 |e<2~ϓ@XEsbG)y qr|ʝGSQߣTᥪ-wp,Ⅶ-UTgcܜO郾`lEcCKLad:(k*P: bپW~ɳ<8KT"R_0icVPY j%V @4M"_"fduP:E,z: 2$<u\ͯ6XK.|jhUݯ#pnf[vuYٷaEHgk,>y>tmMɟcbPlԥ+6(R#-dh6MKÒyd;9uO@H۳LJPZ.R5ԯJˉ[US^Ew)\ҤvU0)A|.ȶGi R4B. Ц`MFgp'Ukqur`N[Հ^4зwD0*^r"$I 2@2D4\*"(%֓Ż͉;{D{y&D岏)DTدoI}{YW5Kax8թ/:}-)74㬾@&9q*IQR(%mʬ)'Jn`+{dsRG[}jb0HXg)^yqc'hQlDq`!f^CCg|XD1}AIuoP;K=ZG-+IhiIVΰAkyQUL,>&LO^X)5G&`; Q_[Щmۅ2ˁ I'ҖoyLᲁ y@-_}BHs߄~@v`cZ=;ߦra!By{o{KZV7;ɵv8AB.0ӕ:UD"M޲o0 C>&S#UK^Ϝec;uڌjTِ* StނZݙ&dzq&ͳ"%;~/8vpqw`!tTLW رVnnw*tCօQYB fd O!ױcwm!h}iY`),Ȣ0f*9HoOɹ`N]L lM5`obUG8ҋu #o}v؊K9,R*"CHaŌ*+i١PS< mF9t0Efv72}0~;^k8.fo輐b,F/ͣ7SsY]˲ӈF`F J`o-U7 5%! нlX[ mŬbq e^*=$Q`ķcN2֢&[-ݴ\l6PЭMm`EU8,it,_#݆"9e$9(h[UFد`0] %iq,B/D;2Rrn")|ScW R ;BiʓMm&6M(ّ-C=yB"c2ɑc9螧9!@!{UI6C"<|07W}o:,9IЖu)wϥ{ ](ʗj6?o4ΈqG"v독a|^!!x|\kXTZWhp\5{HHcn҉Xu &c:yE因Kߣ=ki~{w_TO 52" Z7k ɴ~b J/0_a#.Z?]w,qBb6qa[arh[cN` jY 'g/>.q\)gh[ W{WZUJwKc}?dMS"}9y_ʊa4nFϼL;ڊ+1;K%3 0)@Odvv?j:lO$°̌Æ.3SӁ2MӾY$ǮkdwӦCrP㓳h g`;^-QluļýP "oWhr-qq` 9-Y5Ty96oXI=m3[xUyGkCً9WPD.Re#2KWGM;tsCNyKOK8X,ZOlAL+ӈyCkY\fdc-VWijS?p[ȥbQfH bБ=c+]֣aaӃ%eۗNbi[b:NKY㠪u5M=g4cḷN^<ݠEV~OSr ԃڠ^6d[3H5V#mGY](Elƅ{>=@Ha% y 4${1+A/VQr[A)!MnݗÉϻLo-(oQ%MFwEtsW{S!{#z}+Ck"xZk/D׎Q?<%YnѮё3[29$6,];J B\*_mV o.9xpH/ .RAkWX RnPYB#ls>nK|C1e'c!"eKte'5FR'3P F+2S)l=Ghh٤yvW]_/WRF;7>k6&9݁z갲7Z9_k-sfįSvDTN ke`E:T Q,ddTG[Bf{ UI?WK ] .%5'@ vk1T~~G#rr/iBC pzVukq(9hPUhͧĽp⬈ҡ*ǘn>3]/QU@qa.ΤXxK8DW&ahvN;tcRL#06OW38 ΨR?r\)K8Bz0~{aB\;nDµPE9iŇЯ&-* C?~.kˋᆳ3.8 (ܠǕJ糑Vu>':[]T$1OmșMˀ,w8#̅xw zW3 ]Y#̤4g-(:fw`BBC^~(^`FR7$y;\]T^\#}ИX?UE H 0Zb]ٔs;*v†BF5SE{/el Pp pĖ}aEX3p/IƢyWO]b2t@qj"%z8mIx4}95EE+3 *YsrzňQu˓g %aK@fE%JP++p4بҧ5W";O 9tƝ=/K&!8w;nUJh ~ǩW3]BKRbW4%K vXoB L|A_YF6,mKG̚f1nT)nteXٜdR"mm4'̜Ҳ|ͺZ(6gnرSvq>R6DxIT;xLB6hL5.aHC]niwOi߆g-g۵{<qAYcZ#?D* }E!&G*U `/Ll0)Mɪ{76hi5]^oEta?#!`MsQ7Nش/ҜAd]f!y19|+2}ޱ[0&0!_yab1{谶$KVt_y˪ԯLlߒTu}(Р da4K+jAB8|-,i|C1XPЉݍjs{" 嶫UbZ gCS2y-T:GBZ} >ҡTWP*drg샿. |⮆sZ\PZk==rsʹ<*,0b 961#.ǵ8'm\Nϼ5ʿs;g]zM}c/`ԲW؜02*h+5[2tȭDI}3f&◞Ƶ8 @7Y7'_:3#\qOuTdLo:c`>hπ9rDTD4_;~r2h*#PX7՗WI23[EhUX ]G_s4"3E3 = q8%PjԦ⮕h4dFܝ=oCKH1YqD_͙k;B]+lpU2EH*E   IsFp/ܯLo+**9hƐaM\2DFg&A2y ]Nhu>ĭ6I2pw4&څGϗBG:7A.ȉZ̺8/9zaoce.el) \{}4XA9x?MvAOF5B* Qh`}sFgkՅԁd. r W_=TPT궥-gHQF}_O>8q-l%DxHjACTFy\6TvA h(%QiFlka(ٹ̼4q,$2 i,8r !VQ4l!eT??QJ[H>WOlc;D` ɚwH|jm\cPO @1F \^T5P|)/Hcܺ3zx^Ћ55U'e6Mkkp*eX|`5>%C7l,D N1 gXRyRbi,^hqsNގ.es=-!N7qq!o>59%v)%-e{sf&M)n"ze 6"eΛIq٘ k Vן%O:8?dEү,b*9> UT Jԣn~!|(z82~u \[urp+]= X"Qkf{DD->VZjt_nj}L#E/VicTڈA U$ /4Ī7l2j9, κk-0hN̓9_q_tDUvZS Pw(.+χI5|w1"TϡM$7-zaߜm7 c>rn˞/>CYY6d#K牼ض"I`~ .􆈦IB>y6};(vS__DžA|RcW5*13s9lW H^(a}+yTi fhFF ? B"|s-sP1<5mSf*crkL(vR;0xg٠d('`oW*k6U5hNeolG*+o`{*7]1Yk9*͔qNRUy&Ms~-qP .T=v"v[z]^(f?]EGirт1mj z3vZrp!68#N}錘PRݶv3xLsAb냘hd2",o7SZ,iepqGlp+{MhC[R3cUozч.)3&Myd **=p(V9Bu偩xɣ3jD7-&M=@}0#D޶P{:O] llʨ)q1`o!)KØ9(䧖Si2M ycʶ;&2& Î]~bMIh our 6wZ Nƣ' \qE\ۼ6ЏxkWRV-Q(_wZQDʘW%9>PP%ҥץLpm&D]˅  퍎dA=xY/$eV$[h1LR1\Zrw&Ca!|O: # ,X1Pv^Va%v6\TX;Rm\8_)ACZT?TF#ZwE "YkBYP덞Y`fxX CB8DЀ }ԙ3puq)zⱚwq\(][ct^s/u(XXco%6D(қN fd!'.69S K4& sZs6=>Y@46< 7Hx㡨',qc9D0<.6؊DIQfiZWS-<ljS7?\yFoQomY—x /Pz*eLf%skw󃖑!=1&e$PvzK= V" - {QXQgAWR,/}JU`׃UM^uVaCi,i 9T?Mҧ]ţtwSزL+ c>'陂:>o#n'oe "?5Rt ,狛v(.w%k p8質P5JxB`FV.Q㶟>_P8~߮~OjĮ 5=v9Z_41Ѡs3EbW\䒗Cb>J|׈W^g /\*#~>mcS[aő}BlRlBj|Ml%=lS[Sw)4C6n_ `v r{kN06cUߍFfK?j`~rcЛ]S7,< NS0S+ײ} ]X &}K+w.tfe :RTصui=r|@alK[c舘e 22fgkZ?[ &8S:򦝩ۢa!ɜcA{WN^_-96pߧ ؖHQ>,p̈^fU5 ØMAQEF│?# |g$ŝ7"r׳[@e/&^5!M_l x/cw1z2r\Ηs>(](!Kfu%[lكHzꦉVkQ>2G'/ t~x%~TO{!X&I&T YNҐ 0{C `jDaI0vrnՇ|y6\tc}fVv~F2Ug;3R+fhw)[$0kjD^fYu-b͜JdBiJGw8 gcqY3~' tdńg"dLE'H稤b)\$R@ p>;~0bȪ\*D,ǃSq I|*_0<ͣ3zCvZ{a8`mo89fMW2ۼ6H{M\`[>ȽS6k a|+k"H1?gIX.©5zl–u^XԎ ĶӌE)l 8_1ǶXIiц Rx~όl_kѭaUn,n o)l[fzz~ pRA#E )76!k܈L:BˆjQ;?t[[~;~=?IJ /fe[;$r4ީh1F_ϩ1ޭиeBD\yJFFOj [i g&^Gt0 x :K)%w 9,9mt?ya)~cƍ&47T32zǺmZ w&-}ys٤Pv ӰK&z8eR¥N;xܥ|1v" /ӦYT0OSCyd@Kcxӏl`C=ɤ,,D꽈7YȔ灙]lհ^cnRA/Kk?x ]ߦ d5y^ L)i# 9[Ǒ&8;t݈io[*Q O];fphar Kh%?QUBJ'?/3|(童=}k/6Qᢋj`|+x|tﰛEQrFф[C[ j]ᯍQo )~czBDvis Va>Ư{P4IT)tg#4hPcoD!g uvwAz6Y(浽:& 54!dTGV3p}r1ҼnW՟5+,OP; _.8UCBA&eY1bB(| #'I~N# ;,/JvR&NwgI'g=8紋fSh'-WO@?3wwhGHf\k R3@KU {O/3l_13.Rٛ D!r7{Vsb!My qJ/w?C>uu]Ye'۰vkoFʤ ].74w٥ju!oz؄Biؤs;)nkg&'V";HOYJ~PAvF(N%98AC˱Xʭ0K%{Scq=F:w0ktꔂ6YwLh7g_wq{18QG<]LJYRXӦиok;Ǚom>j aH>%I8-Ɲ<9@nhF.$2 _b]hT1yQyI2O"-;3l@? A Xތ$Ҷ>dž_;$_?,g^D1 LE4)w YX J u)z8Ϟ!{PbFʍ2vjZ2-5/Z o!Tm&Qh;~F6ݳ_N iٜرl%]\W Ne+pҏ$ ?Werai$m 16} |`V_'U99琙[CF&΢3o`sՒ#n}#%g`_AeT5 c̦JI$EV~ˎ (V 9w'53uX.-r0c D?↑oĺcJlbHdDcyյ"Z8<Ϩ }wmD 3ye=\^MUc§\PV+%Ї5r~ECР{.f犲^awo ;gQ,sj6" B'͚kEP0`ܠlunMkfHo 5Rލ|_!ǘoȆ])oRR,5gʦJ%q[)Jyu•9@Ɔ$|Vw͡pQJqa~"E8 Aa*z\(Py(,_+tEײy'`}{f#ΔR;֘궂=)@`F~Ҳ~ DW@dn1% }DYg)W0?A3:$]w.TӖ~Fv{gG_k_?E8>5A^sbuxX{jT -*ź'c~mJ\CfjYE̛?Pv[}7wP _䇚" E9D˴Yt]-! @8|g6N^0C{$j_c̃8 PPwo Z]8aW"N~:+)x5` dihsj/p.oMQUƪhzjQ4&\,c >bjS;~.蜑f *T8`zبAp:!2=?Q _Yք TK74k7^;ˈ DAV."hJЁdí!.`WVrR6O6_(zXxR,zo(I%N&/rFRIHwi_ cEGlbAi{ b:Lu+c";z'O!9lYmx4|SXMByž FTT ''[v&@%ۘ|%1|>jTzWv44^loC a .]7YB}ZgM#rwbE3w$8F1^$eVCg|jl:UҤΒʯ"6^|^a47!B#(o'XA?&"@I%$FK<8XkT%a]Dקn,7zLLUADtm \`C|ւ*sy!<$S㜯A㙃t6؇8pՙ m7\DNHCbZ Fҡr|G{- Ml8@sKYLjAΉз}I$$r,)<9I[ƭz카ZV/_ ba'}g]Q Ȥ lmjIږ8GMv 0 XJ)ƊXӹ5X{b[b0Qyi%`cK{KP"LG+ 3[Qn ))?C|D __v-!8Ԫ!R[RS&Jm<> ? PF}@Z=K<*g{7U)hXB)\eTI>"e]1:l'.cX!PDA"`8ؓ{pe$nM@}@z9H%-ow-ʙ@9pй'K~5D!znp΅sT:ÚRO-i-Eb3&EMv":,y0/5 鱲?׉鑼.OvF P @tct=p%}Jz."!\Ab c.l}9g, ]VaƌDG,r\,ˍӡqwHvͳ2uKM 3a!zL?'PvF`A:dn`_)M8Ka x $>}b*`*2v9H|q-T5xRqaMCjY~5BXCP%sZe63l|5ǩig/,0{z\w d9saL鸨 W /䘔#&:r+UWAI 'HDlj8*)̞זR.uf|MN6 Q_D,jKڋ7J +ztҹ58޿!(Oƣ)_Ca_0vM7'x|w#ZCc;;k~๡R,X#[aZ}}j'sӪ+B\)kTe8d}{e^N"GZ |f6•1X?LA(צ~X2eOi}fj3 ?x11nݹ/zZ%Kxx;$kY&}iy䔾Nilc{}?8Rſq{^|P_.rA :Kѝ/DWt@~PDtlE;;xE.W"n&A Ftu*zcgMt[ 1[\]8l<ίoko_~ a["a95̳M[ҳ浮[M eԀ?:OغIEzu j(jؖodI6sxD%Bo܀\ث,gHVֲLHFKA K#_7Dy<1ZZm>$k81陽`JNfqM0n͌ݑ֨-d5㝧n;If'./U}"8m1c]ę[#Nw ,mБF6 AM3xF >>-֢5?hb=SI7]PT0)(q5D&NL(&ɪd} ƪ$l6sn*r5^5^5Ag8,\ff>ֶQ6t(DfX:@nlo\gWcSRomC{hm.:: XƬd:[c2ɵ n yZSBzvw[WpD&5Z?~wz_JD͚IXaGUiG21ś38]k"phCԐuk<뵖e?i&Mϊ̓d~ksܕ>'%+}Ⱦ?Dt"};‧WN)#E!-I+(6^-@p+kl7˃`sAo’aWXo5ŠGWR8jR*ӈs dکXDB BFJ:9L3ƛAT**o{3P/]X'…N]vyQͭWzu?cEZ5}#Lj-1^0c6ƫ2jt'z6*CC|H\At"-\)FA zccZkT7}'(!٢#ZGƐO%b,PIR(_qE5$>An @ڑ=K0Aa.rL}2hZH_WI] )t)8yw_ >> Ovm*Lw[,h}ѦHRqB́`sDa+I.W "Q V(*w8x.!ZnBą\kyȃ5YAoX\`UCA# 0܅`\ 81h-Ri(.bsS<rjc }ŞWvBTQ69v5%"_[apwu?Cƶ{y|0=BQZpX~6]c ;v? *z- M;S6UƁ= m H.W3(s J"vpoo(`蟠[Pt9F[>_GVߧͭshNg̘eA3 ] =T A\ OfOd}f.E?*+ᦇ;gk]ܐ\C^9~e䆸?"X$evd`+{ܴʳ`zx/K w]Kj?5{8c_`K¨/w[lr寑-.Q&}` ؘZs)(يcH6(68UiQa_2!4a8̟Ѱ ^J#8Eq:lcC#<㔾9Tkx\v9gNEs$,f$Jݼ>.0 Ws Kz^(TG;m Eؒ_ h$sDI5ÖƱan@-1NOe(4!kr`s`Z70QT;ǣ%*VRQDB$ Å2|eJGLQ:K,f2uԿ"w捳9t CO@D#/cUMR_)5-Ld C= ]Z0B }^kl&qwnɜ~__ט ` BP 5CٱyU`C&  wr*bV*IcD֚w|W]<,llr,O՚=,ydp4 *D/`C8z+XNV7cM),w8PEEmq--MpKPNQU tR eq||'ӗ(^&zD>_(݂2m*=`)`1M HL/LeJ&ý4$E=EkBlKH?P"fjqJy`gW]}ju |@'\e|#EY^5'n}49>t>` X?gYs4&: dUP:y u(6dHd #͘Un46WxΉiՕg=zIנՒdJ /K@*Ğ{t{H|,}lRꎼ"D;.j[Dalu ?((WϨȡ%?ʄG H*j|r$*wNlX 0Wj !Y䏄tufrg'a9Pvi)/'V/ +@i+$RD#F2DHc^FARbfKx|;NΧ4s-rε€{"fCQRRd,[^ޖM{`CB+򚆁3oz=B~QtmsfT,nPҿ5QS v$X+v hHtO#;l)zN]!z(x> uݠqW{M{}6WjiqyǴ} ".Cqق<9SC|l=c:k|@Ȫ5efv?$fR ;IM>T`fx>w;4Iǣ:3'>mdHSWA05#Ɋ: `iXI-0e/ju9?a{GuaO8>׫Klbs~ 8נft t'.ˮ2Ѹ+AڹBws:ٜ2G?%2.mדA hum+gЗfkv.ʈε`4g#o0RɖzsbE`'7#h^146"_rUj$$Oeu w)?OӾpɬN .MphcL 6m epvJ})AX̃\' H+ZyE,X@/jI|ɳI'.(KIzgSgR B-(N,%4P.ZƓ=(ƃ2FL(׋4Nr|kRPK_39pPJIX X4";f ceeM1 f3;3PA^H.jsT~5#=3~ٮIYIhI57T3~ :^kDNIQ0^zK-pl=Z{Hs6Ѥh~ ז`тg'Ԛ&fYWDo| ܏EpYH4UtD'ruYCs6L2̃#y&S H \f,!C gl,\ZLb;GSJv1[.KW&. B2oZi0H֜"ZH eEbu-J).!*WFX Yz^kT1f\mG51:8 [}vzP_gSR5Sk80=huODzuy@@C[6SKkj}JM=ˌѸځ4/Nvùa\Z?eMAOCv=`V׶o8As.4BL҄йْNx֔sAQVLZK~B"ƱO9n |U/eaU=9"RUʓ-0$@{wXQln_0{t4tkOAuKr::ṭz̊B H3$<$p਺nѕ1.ITP2h:I22ĭ#0/(SLbݔIl${J|}D-$LR}(,me"0DY/ˌh^fẗeF}O#bFfb,>'o9>s07SwVw#nEݚj㯣:Ϧ/vPd '[KkNc 7˃&q*6?y}52&q\Jo>}Y_5W J/yuyv7j'R SKT ǚCpk%䊜\ي,x w KL'h3؉LY^jW!;QqU O5% Ȼ1~5؊W/8j~-,SEES" =F =g:ޓ1m֚{?f#Yg0'C7Z.Y,3i^N&Lb }f9Zރ7ILE_ScoHX7%I3QzVV[h3OԬx_bdS;NӲa٠9i&+7l}@`cٳ`f'GyLHƻ~@<_u=\3Pr4&Xv﷌s>du7L\jW#a?W$_]诸P=3Nj[nQ ?nԵAA]}AHꊊ)ߡT ‚t 1%3T|/Be^RuT"-b[Aba1oFMgs45Ե4)nwIyğ0znV>umj B"UPIB;EڃJ@ —e\W(y<1ڡ%C6@T' 6j[ٟ85}oƓ<gڒMsxpN+Z#IMW")\|V߂;4?kk^R ĉSTDLk}I;:lLv9 ZSb[=/Jo_Ħe2cɕ?D܏uZ6`֨rc48ީ:-s nw7=OFsצgksĐ1@,-^rlVACN>D+8ڪ=m+68eセ'%F F,iHAFjKM +LM]-o ~}TFJdz\68 Cxn7Іv]%m_ܕFߴcC2bgN:Dgt5X4ekWSB)l ܲ>UY&xT*em %ɬ':DYfQU6Z}ѭD5OS$btސZcy?|I*+S[|^w rA_'A 1_-EݡjG%FcM䅒1I#RiA d.F^k#ׁg@R: hN٨k9k덲 0 MVM'Jy1\6Q 6[&I̬]M<溛(Jާ =1IG%&e(^`xnwnAv:\Ƀ3cPvD qM40oq`+VkLBA[O٪zaA3kϴ"%|AFc{'I; Z9ݕd"[(>H#PY!" KƇ;& }꧸1/ [BγsZ 'n`3ײ^! 4zEg -UE$L ;_E9 ncjwABvq$IX\%XZ}x 6py,i;& qFgR6$=>!z̢5q#8d^] 4f~8 'W9[EXM>҄!;=B)ͼR^N3F5 ɧ8(wH7#w@c Z @#?(3U!~&˗z?Kd*,8jeЛX#}Qa ɽ _jY+ƍZQZ+4<8GHA}~>K>jti|[68QK=0u k} E>&BuFYžk(wtv4G(.)mS'] e[wl@2;0H&Փ JW RkMQ l收>mWq3W"NoH26+iqWoljJmEU7zA3˪ dl'I~ZwsX!yn 5巟Ϻq4)>Yݒ;IVWN4c'[c*ct '6vy -r}B?ȚЕfGƍz͡"{K4H/U/*pjzCU/dsmR,ԯU13ٱoKA364ʕ-0QE&ZMC(by1Zp)܆W2FlFBjrI ~2( qau(pF 6~jufV }@]] q}AQ B`\x(0gt.d,ߺGQ&='nV=˗oyUV ? endstream endobj 2997 0 obj <> endobj 2998 0 obj <>stream Adobed    ' "'''''",////,7;;;7;;;;;;;;;; $2(!(2;4222;;;;;;;;;;;;;;;;;@@@@@;@@@@@@@@@@@@@@@@@@@@@ $2(!(2;4222;;;;;;;;;;;;;;;;;@@@@@;@@@@@@@@@@@@@@@@@@@@@ $2(!(2;4222;;;;;;;;;;;;;;;;;@@@@@;@@@@@@@@@@@@@@@@@@@@@UIC""   z!1AQ"aq2RB#CSbr $%&'()*3456789:DEFGHIJTUVWXYZcdefghijstuvwxyz !1AQa"Rq23B #$%&'()*456789:CDEFGHIJSTUVWXYZbcdefghijrstuvwxyz?MU}39o:]ޏ9^8常0  !$XHj JPIY5 @BS2. Ѩ*c(Jj0!J$g 2Ю$Jɠ5mf2$dqe`V5*ifaf8uVbaVQT1%݅1Bd U¤dJtm c&SBڈBL&2FHJD7S J%DD̙cv5dɤDZJ&dZD.0'Ѩ.RH MS W1ZkFw:iD2A6E{I (,Yfr̭WQe+P baM qH4m.X@}F|֋)؎-"@ L++&H橀PQ `JBɳYiYLRAk"Xy %2R!1j*T: D"0dSh0u g \b.IИ0 ݈&WB"bsR!P &(Tw!p6s0C#6w s\GrȞf [Ov,wa݉F&n1Ug D&09i1i:ia[XHqV$ wb.1p [UVP-IN& D\a"a݈5ZT Tb+ݛ^csZ*݊wja&c,mpY@ eU`(DL"y HA D V@-$0`w"h0Ov 0`E$م@9 )&@M+qG3 4$nj¢܉Ԫͭ j- w!܉GHH%g)XPP@!2 D1f# MA20J6S&S9#fzIBD$ ${ L"DUvc9StEv'B ! @e HG5\ L5))*z ('0 EBDL)Ba2P$"WkAltT+zMH0 FII!QԄT AB( qQ(B4ZطT3&1U.ie8@)E )2Ji!2 $m:9 a"Da$؛I jȩ<`rS4r2h.P6 Q)PQc@"i@@! %uQaQA"(Bjt%Mm'-BDVscP0$ArP[4IQ*4Đ:!7* (@*R+k$H DS2s9@HPJ$M"eQAe/9ѠGGs*P" HpD6(J@@Ā!! PH2IA(0" (DFRZ(Y! H9EDJ%c-G0(D(dY"%",@ id* & T $Lr\3H"HBB !gD^IRS B4QIjDLGR[bҦɀD6pyPt' d@Br(VkiZ%R# &Ac KrB'.H$@|0i@JOف"|GJ @#МӚ uY%"$$F'R9Tޤꍩ(TrjHCNC<%sQY-3AB|iё MDlʦpFSk2f93YDYkv3k ښFuV"r0De[5[ѱ!`CIRE0c &T0` +V]A2%"!k)  ,¤)'PP%  ʊCj$s/RTl 6`$k*&XJ4DGGs@Q)$I*Nd\!B%BP% J*`PA@6"TH A%Q" %RaIJD% A(@ DL @9P $E$JК @@31ILTJRa#BPba+b^K0й@Pl0N ,BDBz&r"ƶFf)0Kbt )EM謆C[FD!&*HDvDe&r! $kg0X@EVȵќ_\$%*&]DDH!@!(N 9ͩ̎ #BIF0D+J:$Ȧp 229Ye*4eYʈL>5%ڞ,-Jۡ&m$IPJg%C8^D7R}ۤH9#ȉ#haR Z-ڠduA- a`Jty+6Fx őI0Ti: &UIL_$=M_c.f)ߎxmvqTLOT}XqpMv:'eoWly1Ss qD&豹vf:y]qqymiyW?jϭ{v]y>A٭NT;C==flUU3̾Mv4&6\rUEqN{M,<'|W_kzg ӷLon\,moKߧˇUns]X1Ϧ+<FYfY}=uk>0ݎ>.G=)W r['jk1ESuuOmfbs|UztbsTuݕtxݯ1|uOyp9]ǯ,q uRQ #f]'a@ZBFX@J*e0N@E$)j"B#\AOBrt'qI̻h9\F^jsNs2LܥI#FQQG萔( *@ J*@B@H B!P $"d ( Ea"!A(D 4Y@  dYD ɅL$F,sH(@%Yo QZ j HȲP9 "p` H!(.(@  H9 *g,Z6k!FRa)BH* D "D$aE_\#fb<-Fu4|>/?&<|^I{7g>lz7*hc3ǩ''cdoc˴q,%YtI|}7w׿ͺmFgUqfciLݣ1=:_Bwjs5v3r̋{_l& r\q޺opg;6~S+N߱||4O'{kӽFNuowM]g{{z3ﺵݪM/SiZ&s\'oWpLljnXvcœ>՗[z<^*߇pݒmy˳y<\rN~;:s|n\N\{>j­3vlꫵ+7WksbxZ*'08 *%vssָ6&s珵y䦟}Uh4|Ѫq7::jW ^SDU))&^2w ^p>ٻB8bg;6M{*}-^}nmvu̸wilS4Ë|MYϙhx{c>~ҎIPȄ"("b(B*H`Ie0N5 #Hr *d tNk0JB#uD$JZ28 q;Y bQD-KE*"dm^PtHNE@@ " @$PHP@B@!A @p,BP $Ia+PP(&Q"lT bI@fED! !`NP,asBP*J+jJ,I+P\ IE .P@"V$4'B $E$("6 )Bg\iTdY"DT&N @MBG%,D9(sp cǷvFginCn#]ؙ9ї{^3R95۔d7پ-[gn/˕')-_fwirٳby?u\;Oɾegaϼy3 >(|_.RoyIǥ^^txʦbfxtO^zt6oQUDFqDO}ձqMSWs=>7~uORۍGx8pmNx^\c3T=v}}/TU4Lv3}qu|L;yޝ|so89<<&sjٽ^E'c{3>G6%f\>Oh.[-*;99nC^xL<.柚ڙgn/j1:6>""j;ΪTLz Su=W<-޴ 5x|,=;/$~OZ)|peryv8Yc.Grfhܙzzr-MULb"3jYSr1]^2֦k\Q/;.m~ n]9'Gq;>pI]ni9t#U|z}5oE>Y]ٌM8 pe]mN3ul#N73z#ϻrǕ7S ݷWz#?ۇWV(-}nowǘ< Sn^ڳx^+rEub&pQjk-Ȋ!;K'Ï.Xn_wgj3wv[Qnb"}&]LN,<۵f9tu4D՞ϳ5׫9=\^31+''{{~^-y 1f7Aߊjݙxݪ(Mv8Z3 W+eaޓ}{ww']Xqr3Vr)<#}gݳjW-ۉgs| SL΃ǃ=6|Sva==_^4{={n&[\ݗn29g9ߕnNϟ-=6wp2V_~tOM3/٪uQW:fb^י|n |luv&gsx7]=[qsvcg:YI@ &TBDJEʐJzA8\!(R&$HlL($Q/Qb1.iwz>>' ڳ|Wל$j USTg( Ҍ044߳հKfܹ<<|ͺ/[s=9NS²wx<[nmYŞa_vXoPZx30j)\ero ^;s;jAwXKfq֗SY>6<|/ ݻ2|&GiEqtLL:=ȫ88y6W8& nk˳D~q7[tOIܸcܳ,'xkONS\S<&w;L\;MN2zdcoY}n;? a=h+g5lDeD,2BP9 %rD%(H#F2<J&ENd2djӒ-ѵ)Rl̝Ft14$ @ "( %!P aDF2/$H@B!@H d Q(P欪T%%0V+IR250&X4Đ[/4 `!6i %L*F!y, 9"! aHi !`HQϤ_WXUs=Qlu3{_M2xpevV)-?ahǸj5xgy_E4DQDS.7<<9cεǃN'7,s=үx8Ͼ9۸.yZ=b׵GW:XZ]DUW \M^Ow\יmkfNz;qgFJ~ xs|#ZxH{?cqܳ<8۽qNｧήWg5LX*g+WyYssh;Ofc.=@HO~ʚ-EY#3tvŭɦfc= wO35ωݸ?[Zzo3/2n{׏:ê%w9WQ3ޏ^Z_fbsJ^f2e}g`ge\fzXw_TG^&=vch]oH=\K6/i//;n;4mU1ߢp'Ï;ՇMe__/px {m8/ќOnȫ8"3^ݛ*ϳq;=5ZӧGx6Ym/)o꣭bq6FhϦa{1LDwzyZ}̧zY8\L{kw.y3zqO>NϾ.WaYUڦff\*$㚞+jyĶ\FfZeU}X֙VtED&Y*%P(!P@F',@@\)"ң*P6Zr^@uuL[Oһ)3#Wf_vn7伫rFu&9zZ3)ef{n8䯤dL"X"Y00MBP@A"),*j}붬ǡۘU>\7n1i/'y;'-Og^KFjW5wyDw;7͈S>s|^ݢ;itE1RNXM=to]ψsNޔ]1|W+sh\Ͻ)KQkGGi-Sn1"3pj5ޚws3?axN-Wmz:>Qo w'縜\\-F8\SGƿYNW'*cgna}m Fg?6k.szGyhn6S맪ʧ335UQ;(Dv/GX; ^яy˳v_US ;Υ5p,NWiZܯz9UvIr7ڦxx$GugΞνo3̦:t[O*v՝×DZpqk9)8qM܎CUo9>\MLc7YnKӸuO:>Mjrg\lۼw-ϑռ4;|9sz\Ѧ队 qOj汑 ^>G斸ie}ˆ8ωRr/Yݒ_\ʷ,YWU=ȫڢ&'՜qx/akϋ}9_I}=}LLJYdoǭ3T֢6vV9C{E/  DX@Hڴ%\Pm'0WƋ;Ӧz1x碽E=Ҧx4F#/3Ws=hދQM4ܣvb"Qp7Y{ϪV}r {zn^L֣ERAQ( !"v45E6隦z"2 aW-Tq|/oU.?hp1gyszVpc޾[z})kc3<_a|WcШ뫟}>=ozUWw+U⇟K+ >ǁ7OEٳ7k1'SOTpy?3,m5G<흪j|ۅٸ[?ޑݧ/ :hx{Gjm9<[ڛ<jFSDsL+ ,ucFTN5adv2gͿJ/]GWݜn7ўרxfb&q3%z1QnOb| ׏OZooqOwm-wkK6q>N8QFg;iݫf3ZM̸|u_sxN] rW^]=sEq.ODDs>(:T\_bq$75;Gd{'<2/ro)=m[=만z#;t+U~;jc; ͛UE橢ޞ5q'nٍ^U"p1y=yGct߷wyjz<흳//M^/;vt; W3K%nkQv;.>)>e֡jUw"i|^15Z<}NڴlQT5][Q&#Qsk܏DŚhz*U9N8ܹ;_υe,tһYi5)8Og|Ry[発o{'9jj\}fѴlrf&8UL*z֗^VړeX/4x{q_'bL+`C){?Tt]1stTWULO.U:JO8w5֢5Dg .Xw<Ƽy\?ye}݇wgNjKycsygoUy~fr_:}W[[V{_w1 ͪRL3wq嚷&vwE/sG}A-EN6EI\s|pv-{DZM\xO(</.jySI{_-׽;*T)Ft,C`h4B5 !DP*]*J(HQ$@NP5 "KSHd8=]{{7wQDSoF{aEջ3|kN蘙O8Rc;pg,ݺOa v 88s]w=$8\ 2g:j5tT'zarL4~7_]*{N8p_¼Kr|}~7Þl=kzSp)Y\./ywg5ӲϟsSMV71>ݕ*ʬL'{Ug~bN/>Ycn3Y^nb9r6=T'wz?Wfbbq^mkƟU|N\;ͤd/ٲ,zcĝܺ4|o-W5|.%]Uo.fľnlyUork~c+}aO+.'^3|vYfG3n3'Kwm _L$zPE2*$TYP 9+źf|7vݬUϩL8ݧy ڻo&R{AJ~/xgvyo_zxZm][I;}f}|Q#UNc~ݙǙس4_)Dʼ7gIxy ӷ_]|Iݷ :^y]vßwK؜QWq3KEQTp>Om6.F|S>m\z8_s{ϼ/-4jv*ڿTwDyF8C)x4w*5oχ=g߼S5z$GU݉&ĚfjO'W_M㗊b=0<|~GL3%lLbmUϝ>8twpϦۘiތ~]q||'n7Wa˽3/e}S w.5˅Kʱ w(ֿ$yjmSuFcT>2ES'o?JvxZO1и[9fRYҳ[YhN#.KZ{DՎ3j8I'wgslmD͍U\")'a,y<;UYx>IxғŲ~?&g3<'YՇ[/M%v:c/v=qS>ix:*&&Dgզ芦g3yq>S/y#ji]錹%vxv.].ZI}{+vٖ=dO.{8nf8Io[ߜ{yF99uUo\}.(z)1s˭}da<)oDw(D %9(d %R`XL%*PDPI$RZP{u`t1J @$JB @@T4J%(!  J0 I)RT(@J P\P(@ *DIUbQ(i$i"c $@ DaO&LQ/Sc{OvsO^WhۮSïodW9QNȟ{zWP^uW)WWXNˇ{ÜN?Zv~fvyodq[[N^ٸn[w*&b8DLkMFi>ǔLOCMQDDM41sˆtfvg}%/{e9w{,<i,gI珖Yߕy7 ˏWg:γ[ǿǷ.m۴oWLDO<^zsL8zc==sNM3F3әw_ga9˵r|vf0/[<1 f3رô̦х)c6='4CtnfKc=5O3_̺8}pn?yW̾<nޏ:LǢQ[fSE]燭cy={ӹzΌxk/Y|W{q7g:3T\)uu7&)&fgq9vUF3TDU;}\~Ӈo%0y>WRuQƼ^_G.hǺ7.Q=W\-9q \oqڎ Yp1k7ғv=W[OQN{gKlݝvc\nռvh-ۧ;hQW1lI>~iSkr[] Z*$i\˔;6^ž垾[w)EW&8N3t['Ɩ8=qo'hcǣ^L{'%~y̻m=4WIkkڋN1LO.`;/#G3/y|G97_>-l\e##M4V=cMQh3CQ}ƷxǕw3hgM7 .j{-qŇfǼ֊:Qt^FfwؘǢQ=VxogOJWmq{G n{/zce|sWW߼:t[5M5ipNm-1MS2*)v_ڼҜr9N^gCx<;o|Uy/kg2/v"D&'zl_-Ϊ#=>W;:5Sf_g}DWG>XW>7vn6\,l'u^nOSe빹ێ'{'1vu;*ftUzwctw#9kϋ*ytTyV]4bVbkn#/Fb37 NdzΪs6[VS_Niof|;۸9I7m'ӷv~7 yzoM,^Lڪi~ZZmf'g9>CifUE3p 'Lu|ݓx\Y~W*Í=9_?~&v~/9]ט}vϜ̲׎zuZ&s>4Wc&"7<:lbmӉ\ygqvVLS1W8ϦԿeLM'MpLyǂ췇,%תq|=;hx ce$.^[m~88Le班g=ʬ諢U"z>*\DN)j13ӹS3-sMqTf:"gcN]S+ya''9hBq\S|'v1d)?`|Y 3 {\yO[-O:_N\~Y-u6n[TU3MQ8gq\WMg>LLt1r8ujuLf8S= Ꮷe$K5Kxs)4p;'g/xy^WKgpx=c1Զv=>L|kwwOW'7Vnc;3pgh[t>ᨘM1ݜfwnUSE=垹uL5\fwc}+?M^R^z&Rϴ?yx엧{[\<\~ϵa/kap8x|DSo5{?9. 3;/>7wcv,YpawyКpdph{ww 25Tbt|)m3CHY"A Z* 0BtXD!  HT% @g/0 "m: *ɑ( t:0B@ DQB"!QR I H) @@(@ %&!(@% @@RRYP(ȸDj&ZIPjrL#lYFؽmnw%ޒ義Ksyvoч\v^9 OKq3ccN}ԫ3S4՘qޝ˓I1<_KwXko{oKc.¶oS}*q.楽|OGSφ}wVoUQˇ j/ovڛtN:We;o!p/p9_Nr*p^y ,׏^WEScڣ=}~>8rZ68KC>'l,/L|Ir^W+|g&~g=+D\f&8ghl5<}MgSCGz{hLLw;~o}gL񺳣lag\\/;~}?5ܞ>(zv妷>_GuY~^1~3>}2'7f~mv?Yl5Ȫ/cN Wئ͹KG4gp,NR0/4÷//Y_'|W[a8gnoާ]n.ǦnOFj :_}Ob>6fWW24Qz$f=TO6^^}xv~'`GػOqӧ-ߋ~v5;Wie|^ΏQQ=1SbvnNqrii#0آ1E1#|KS}}vľ+w=cqvs[u-֢mmgک8B4y2OF=UQ1åsU]ow=:=dަ;K٫Tzh?׽j3}'ݶN$;fjxnwWӸ}>= u33$FWub0!8a57;c;N2n7ũTS2joIN2qfwcS5MWs=ס3v3kQ5Ҏ_%L|SLb_h%{sG1/m fU9$[m/<,,flWo89κ.+ܣj76ΝҼGzg.c˶f}}o,>ns}>3ܢw垘'{;=wa>:/Y=65;ONWg_o{ӽSYO;\Nwwɻڝ=T_YU37蛱)r׈geE;?GnNjT\/Üg۷7枦\9ﳾv~w}|Ryklxl۽'Q$ˊ梚Kڹ\n6ЊgLJkentUnvUͺMS4rg8pEc8`ROg]2wO:_=T.S ONN^||^app.&7Ԥy|Wy8ygw{;liMSݚ+sqz%W)uzis1LD˻y5ôq{dM˾-9o7'|N'f3$ў.Kn#OὫovc3</l-&7隢1v>GUEnqf|>Ë|w^LM;o=1%Y:leˉ ,nzv?7{ga&ǟωS_'%ݡz;Uê"#UTS\էQOs>W_4E،XIy2uػ>}o}^?{+$N3xxjM1cyˆj5L.rMG揥O;]=/Nwr~ã^eNχirbzkNoD3ᗛSҤNrkefN}Qwg V9U9Td HEDRSQ0'Ep'H@" ibf a$)z` T \BF&Tt9р @ BPS ! Qa@**0*JDi "@ EHP"P !S$ţ\YFm+>iw/p>Q;w紫Gäqޕc /|{ޕ!\?}8p\y8̖ڢf.˱{UUQj><;xz~V;=^iDMUDOMQ^o݅Om{ޱ<|OM1O(j.Kt]{.w Qkq2Fӻj;ˢm]f=tOŤSJLp>˅w9|e֪Hj! cʐH{vjUmvepW:އ娟 paD9vuTfgł)ҜoNO\=zߢ;IJrh*tטQj֚ߣ]v'Ty{}h]ρyQcLJ5{T<m?[ڔDkt]nS=#ʯNl꩚}G$\zG).rip۸+xw/K絯͎gpy;в<]ޟenU7nG)GzD˒nѿv)̡nQ4 <ܻuoji&fb#8x[nFS˩߻wQ^gZMsԛ__13C;WÝo{\/.;>7Wz'menDL1^-}=Zźsǜf؝DQ<:W{yp8<M]Wz5v\wwoyz/Z5[Kֱފ==L?>[e&O|;Ocws t^dS]h/y5ips_4='8;|c)TM31<&6εl΢1M#==~1Ǎ_|qg2p82yŜ.% g2M$3}U{-Rl!P2H#PEV'1pM'HUShH%J2@2EOSe0H+5&p An"4k&L{yPt` H@  EP!($RR HH J     (a(-b xL$Y@TNluSn3uySGVoUT97po61/zPɹreǟ9ispy\34353i{O=5s>At6r##l}8?eڱL<~|v^&9I߳OEv9\zz~7v{)CimQM1aI$t]ҿ;.>Lyz<ܭ@$XEH$;ٱvc;{yx_WWjW#4L>˪Spu~hx.{=Ĝž9zQW,9JXL{pFp8ۏm><4/z88̻1c‘qrԵ>Wn5uerݣv\HKՋH񼄎~:ah&ոޝL喉{>M_dCaDžpX2ry^i;>6|||$}^QSr׮zzx>v־(zdQK<' +uI<~uL\`߳޸n5}kN5uUKM-ELMW+{G<wpy,yx竏. x=&W}2U1=0DӢ]ڧq[t&0&KnU5ڦ'%{]UnЮ~3zryX˽{vyIz2\ˇ>7fe+˹zf,UWyٶSS≕o]+3q|7SOi콗.\oQaWs^ݧW~I[ Y1D3Ȏ~9u1_Dz'ziU+kKLs5^8}co~-'^^͇,\^yY#=^i8ӳb{z}OCf#3M5uOKkpgÖ8*qr|;<+{fi赽Mbhڢz>t9w5عŠtKsݎK;Zwz zeqp{Nxq1;cw[7s6ϹnƙtO[m}׳W)Oq]Q߃i7xj;ӗ{{'<;oƜ\2g=ZvN368cpǼ>,,{5;4 2z_?꯮G.ޞs2<%8<5o3xz?9f>GwET HB @($BI Q:@VA!D*` @H: F"@5/2Ğ*L/:ͪ.x&Ak'w[F t9    @%A EB H (H%"ĈJ%B@L(@APP$Z)S3={ ;CUO]?+&@W,\Ԟ:wObۘ_N}o lNѫwOj#<7=^pVl[)9E1K{{ٻ$9:.SۻF7ӽ}y坹[|u;NmOoW{/=UkDx!+/䍱㋸\f8ܯ}sm<79O{0""$(B@U!DI >6tڿF#LSW3;ccz}G~[14'40j zCy2oY^.>qo̎{lRWSxkg`W\s|>g0;~jhT'::[3\z*"\>(xv,pK}}ֽ_4{TÓ ˞͍艎.xhcd[(4٧3Οa^S{G ٦Cs1O3I[+'wǑ^ɱ{;Z8ê1f3fh7&"zx1i4Ǫs>iQM/A LJ\ @T,@Rr4V$|dԨڷ{$€4ON`Q]n$0a2d STS@t=р(JA PE$@@BD @ DiYP""%B4%5險QLL!{':D\׹)_yG nձTas)#日óϹ>J՚UQL3"&f|}&US4uσK[T.Dwlxuu^/;$:pw^uvY\;3bhD{n"qx>TS%hٖ[xiU *ePP J UB@L*jXٶqLtG9tHqWpsvouQF=<|Nڣѿ_rqG3:w/o`;m?:}UW1v۹nQ]K7j.;sW*\>>. +㎔-I?oIu}IݝK.wy=c嶨KtxTɵX}/yK}c]ZZN<fN1EҤ_ <'O\%'ޚa={+˾OCߋLfKEFE} M8q}9qY'.**j%y.F<|>CN$yx<#9ۻemee՜utDWT&y= 1s3xG4fs'Mꩍޅ,fN~.XM'O/q`\\l|Wno5}ĝgq<.x[#K"s8xXUYwK\WLٞޢz_u~=4DEqå8zK_*1M+el`^suws\o^n?{>W/7poK÷"8=q*vEW)]13]8GS=]MgwLq֤x~iܻ<3{%}ž;xܚ,h&qÄx=ڭfbjݎxy^|ՙ̳5ap._>\K_wޒc3}vW]\/.]=c1"6sYV<6v&8Ie\F2Llq-io*\BWB/3aYxu MdYDhi' JY[*@je(ѰiFJ)L6T13I›E`THQ0,#\F̀GAs *$e(!("!( @D "@$H(@B@@&JDi# $Bp HistWŻꮩ3O݁8]v)QGM\\^ч scˠ>~8)/4=,lAm%eȷfyE1}^ qn҉ \imveM1{OJ\q.X򞽾<:uݧp{6>&S4},< ~Oyi|nӟ鴻.5hT-Uzj.kO]gd[mu;WlLW|8|Xͺ+8e^yM<#髕Q|zj1N[mr[)ܮ#qOy2Mod?p9dw5+{ݫYpr՗zZi1mޮrQL8OeRW=o73l^Hjmk]4Ūjw;8Lc/16=.S5[TkV&y>e]:Kr&*TDwa|Ҹۺ28 r۝fO'yg$8{)OFyMkջ@(@%D W^1Qf\3즛Tiܞ2ZYH ۨxd?pYzoO|v; ̉nb)ϰ}fй7/W5UTGCUSTfx̦WLn[}>cyB\tgp{&3}]{8I:Oe% %(cSÅg ǚ1ۉ.4Tgz_foC !NlE*g }W˕T*c(廅}]UNB-z]M\Nxڮ}|۸kyGPX]zVNF hwyٮ>shyq\OݥjTm;cT>{mq3>9vՋq6|u>٭s"{-O c9t󧽼I0/hq'IqZJbjI̽lqˈUKVe2 i \j $U`I0!Fc Jt:!(A(a0 FEDENHST& NN0P+Fli iR` \OQ`H&tD%"J BjBj %  H"@ HH%" 9Kݚ*3/}nb澼tWG scˠ1]p2?y\w~9e.kOy-_Wv-]]T_Q.knǼtLLj  ~)1r]U_9y^ߞ\={|xXμjce1K/K+wgse짼?qnV7fuBQM9vgnꦮrv#u\G'y۴v/hW,oN53nIL\^SuJ݈UCmܻUSijD!rezIs\^Qv^Xc=<߮q=5^.,\=>N;a?+LJryyy\\=rW~#;б,N_zc,zǣ~uulnÆ+tՔi;xY89ݒery~Ϟcdv"ΦU)yOr{/w)߫)z{F?y]'o{~Saי{װ}dJĸ.H,@iy@ tSj7i"##r0 m Udtu7q -n.ZSY,hhUYCdw6MQ4[UwhL}qgpXܲOg~G<f\Ix\ 7f3vyVخvc1ϑv+8p#|I|ZvH5x8̦3/;?."_m63b5&|\ݗUfbzq.yz:Q[¿v8o0~|x|l{2K7_w88o{KK߽E>.oݞNhQ>x)|MUMS1K_;7c<.WΛueCqg/rz}׿$p汒O$5~U׉Ô8?Gɪb\nq^ϫzWG淙ݏn7ga1a3u};wNlo]6<9x;^N7'h72,opo|^fvʪg.]\b^w~wy޷}רϽ9=Br qx[<7/Gɔ*bX.Mk?Ln쾒?N۱3s4Z}/2S3,UV_c.6yq-p\k mQ+0}\>=dNY%u8j.7:cjkge"rPJ&2BQbG撰%]%I4 dL$1iy UID$$&ALEJ5DȰ T$<ɐFͧvGAs@` $@H $@T$h!(@)@ J "ϣ"Պ&<<Uj"uϨxxj ̼7n>X򞽾<,g^nϵdÿc<eoeeuGq){znqUGZ5E;g")F +kXͺ3$ež~vnDŽ?/O-óaĞ[ze"c3v[:u33={vh1+LP>2a{ٻ.snzU &^Nz\[=yǗ[s+sprSUp2qpqYKQEixw5.\{2Oyç]<.8ǗWkz79W6UnuCfvy`= V[^3Eۦ!H{ vgM4ϽRe6##9ї9c7zj9*Uުzs,DUcٸ]LpcM{_qEj5LuNɇpcWl]YŤ@"FQ13nwjLOt4x'm\j:ӊ^wk.6ywf;W|zQq8\\;l|҃[|cm{7 t+=.b"{bzeEEw;&p7>νǁ+/38]sKm HT%j\YijO֪d(VT"BBLd9 \{yi,a}gE7s2c3 >n6=|x?oM.[Btx+p[.XŦES~ߎgzJy"jͽ9^vnvܧڳU*qޙbg83Zx^\>g~q_MK8bkbko ]nLl758椚\pҶ69fΫjfU0Ajet$B@$BP%6hdŠLe0Tid (`=J Ai2Y c)B:,iH`tVD[dxɐQ5.DI߈݇vt9р$ %! AT2sH!"$ YNH$@ @@ [fEt۷LUS_Y.kD䚽6FުϕfRo<,6,q.~\LkK<óz}Mc˵&g^Sv08Xs˝_S-X̼V׹QK/k{lN3hq̦b7|[y prOyrnڲ*2sWk{:ʵUwc3m8ϙ]m):'|s>D^NôzRv/3p1}pK<^Ώ 'G̉{5|I[cWt5&GDtD.K"<)}4SRŚb h{~fy#8xsz{8e^?v~]>=+h𝧋s˝\1M<" ݟYkNʏ7,sgs˝W̹w|\{,̾akӯ9<#x=n8cf&|q6lY;3SӲ/[^zUv<9\p[{V纮 p|w%eba~ܱnLS=.{1U3Ü9ɿNUDsiv6;w=N&Yc;`qX|?ztޔ[λ-0$zKjl>z)~5j̻3CejfLL+\Jߟgg*zYv[6Z&"18~wloLLR5:ަs;룳[V&];H69^ϗY8'7ˇo'n9Zr,r1hvye:/Nxky|&\n5=]VjxT6e˱Qg75ՕZskwߑS=ވ㞉B΀DV$gnڏMO~8~`8?.z:ֱ+5q)L nqRʿ9q.?.YId<43Tbqr\ōٷ+i]=[$Qp7=c=~p{_hÍ\u/=՛эf3l+&.qxGF.彻GRWm9NwWew 7f6Z/h9pgv]rsχ̏0{W̸szymnv>9,8/|~GjƷ,ثvk|8ǢYLbi:f'鎧-:J6LU5nDqx<} v~[{{9Ǟ]Sx]qpeI>><2׹r_|?78|.Շhcq%喵7غF2{J;CF9g>hxH+ip~y޵oCw?8kl՘c/Ԟ"uLF#>\L3B(ٮ]x{ry[Ozqj[s6Z󆍵"˾͹fLxh[6W6w-55i1[mr !ksJ @(Bj$  =iBRa&0 TX*D2C@&0JLa"4 9 + H@EDH V§9hɐf yȀ `T@ !BPBP*@  @$fE33FWPgIkiݽE6gcKjjWzZ6]ا8qys]Z፜n1vIeݷz'查yzggz&^0\m':<M]V}kDxDzUm+^~4X)D>>WٸyzOYHk+|SOj` pw/}{Fەߍfh8Mtىu[Z3<}FЮ 16[mOįg1c;j(U4s|(˗Q\ՌK\TWv)S?+eϋ1צ~'g'I'71,h<ᧄ.HiQq&S:G?G2N%ʩ0kjxESDn{O|RzηJxrryn.8v[}}~L}]OgQfcmODbˠ }.sҟ7i˳8}W9{F=+v&f=iϙ۵VN#1a z5x3$Ϛעǿ_U_X ݗ3cޜߣfs( w <5DDsv>#<_>w.;g88pޗ_ޓ^Ĺc7}clE]qo9=Lcz|dA5xפ'.N?)bڢz֘Ĺ(rx},^? O?`]ELm+U]Gz!;u{$MuZњc;~>V5읗ڸ*>s&Z4$_Wmu[^utSOgN̈w1g3ߗFqgF3Qٵv4ϋ:ʪrq3=\ͺ(ʪU5GLuO5;c6qI\cgĺ󧼺G>M'ﮞxx{{gL_Yc}7zpo.[w859MT晞ui/Q]j\;b٫31ю3:MFxqg¿ )\n\\8]w1Yo',']^YNK8˞=/{_,_&\.a|>7+n%V7*zUM11'> f-QjV8p88YUb"z-aw+<|xfau|e}/~mvĜ.{y٬d&,LQ鏭on-8DD{{=yru&sWf׆p8I&gf7W.Soa8I$ԞDo.j߹T=|}8^ {W|odQjsOOZ8f]elz*ӔeeGzSxp;cyk_,ǰp;v>u>`y})v/ 2M)'Nƹ0|? 9I?.e%^O&2rӧy]XLi͸9g3G5pGp+J"{gk]+kyޜ0;.[B*@ ,ibK1j eDT5V|vdfUU57|ErM/)xa9l'7BMpv,<<%<Tw0ڎnbjg)28}zEnVܝ"gvr\5abf_F8+jֳ52͕ɩ$Iܔ)meнг(HI(`"i"P  @$%!PT'tNBb %@HȨ)T"2.1%f0-P)KBDu t/=р@`$BPE@@ @E*% e@H#3Zi^h曗#z8igYqq#,2#i6}QLSr#5Oq8/6#cҺx}ٸ?hS%ZkumKTϺtN)8Qkmjvg:^mbtE;wceI˚h/yOqӯ%̜~xψ|)߾}'f|L/.]근^GkSFγޞo3Q^gڦ\9ZI7-t޷g+uk}pW 5t2ԓ%|>͎>'ՇaoF.NjC4zbM%lU|oS̮sKY]Czoe+?Gا>]DFK~'[vc5QoߟY;=em+};Wf}gxTicqkO>z_/q9?Sq<[eo:/L9q2q{z)Yoz14K- o|o7eߖm\@q nZeLs{Y0i0NyE|&L+xquW.×sϟzeV i*4ϑK4v:h<ַqO%>;]bW&̵1gX/$ɷeLu.]ن[czǏ;aN]n[ꜷn-cyv8|[~oTڱ3:#xrU\𧵎x;}X 54}UcWmw_8=41p𳕼$oWOv>g//.| #[x2{>^L{{'!DUJ{V]ox>'Iu_40?q;F^圧-|ϵ.wsa^owފN)' | Ķtn/۳ns~<^_A1ygɇ[:vt\&qU>^>t!?gzf^^uXESHUh*%tL2$5D'nWP.ϋ.DˆkIӏbT:Vw+\\C<2x} |.v8V|\9L1᩵[do8S+%nlv532(K%-Vՙ@[HZ 0A#"*'HBBa Y .P #I\`H 2 BF $@" HeMF$#KR*T@T- +t=цPHJ!! PP0@ XS>&8Ntq{F9θ2YwkV͙v}pv6x=js_lyNQe8\͢ڱWku=KsƩݦfV溪m&'v}>p{^# cv\#|vO]Q,1ݪzou8=+c=T8|^ذ;u'ֺfٰm\y};1~LYa4::D٫IG2e2=˗ɔaĞ9cǁ;>'iٱ>I=rSc;Y\.Zgz1*n\a]N]˳qxw=8NJc3naiݎ!9q'wko|\$ޖ>k|Ǐ{D'vzlfDO2aj`[=d^M3͏חwS'.T}~eeg)x9O=%aưtck||;ǩ.W)FUrkĹh݈k;WUg ܮײoI;ľ%7Ey{rKhlWU{VFbz)ޏ''QLqɳO̟7p{w;Ϟߏٻ?kOus>cm֝}nt٣<"koz# d6lr{)GW]{{Xe5kϏw ?,z澜{&w\Zpso;zrmDLUMbxf)ǑϲLWW6tWVvַwgGZeGvuwޔ=y1,$W毥;6=WV'q\^-obF&ϝècgj㵣rzy8Ǒ35M.YMӋ<\qV{+<췗]|Z~o+%x7~|N>~iޮ^<[:zTgŜN.MI:O}|~8cY[3Rx*kS1߉ZƲڢ*ϒ_+cgDͩ1hcxy㗪32gK:&JUqO^~];k&Y:&.\K˹QܭnRM\.\>{.mn:V0nM̰$qrܶ>=&%nJ\)ffv[;&f&mK;P9NIU"wS9Z Ji9!nL(2."t"psA T/# %PT *%0 0$  $*@ 2%9)4Y+,d y5RLTE#Ȉ.L4t=р*1"€(  ( @H S rSjeMi'j]jh+SWo>&P6g.}&8Nu-9Fn)nvnՖ\(3}wL.HYCxgZχfVccSVS,o+DO1<;kυ jLB9 0xN(^Oh}O^w*c>禳>,)TG1ow_^;fWگa_py;kvc dYr6$K2ό\/YH.76q-R㯜wn1/9y|;y燖{}{+N*W3+ϛ^*. V+x;$|fyic,_?Ϗ]8Ŏzi~'jp4]cpyIxL83ph_A'p]>-yGƻsZᇥ:QCEs3cٮ\K'z-w's۱5.[WgMBON|)U,N7qݵ˳kMQgt׉ǵ@[V|oUV]r&xQcGxG.W֩8L2?$zJvLx>g'U-zwg7Cv~5wݾuEĵjb":el5:G^4舯~<޺r$WjKoG懥oǽ|`xo&[ɮOkTgƃEsjTk{bb˿Sн=::8ӏ߃sx2=c;v=gOYowtFv]r٩٦W+1Ø>6/,]7&Ľh41TLLOw>zr#zrٔb{:v^iig{;zk:4׻3ܪ3k.\I;1>j[}>ry}!{~|ןŞ;޶xMq9)&9ު\g(IRy)j%IwLrgrVj/1)j @ef9! \嘆(H JQyU`H@0F@H $@X0 $$  A $(* O$ ! "P%ř(D&9B5h0%]CPѠt00DP AQ @H@@$* @P7MnJh_?Nu<;AEqjg"q;FyLdYLLَ"eV󯛋_y2+I2BLm}>LQpk!bzj13z{^.Z@k9*׹A2em Zwmid*Éɖ'Cnofc2.WnFpx3J'ˉȋټ7 ssXzpX/ɼ0D+r^opge:ˉqnȇ̯wǏeug9kǏ+EjlTYDY#{ñmoSOUf1utz}Qs˾ n/žhv[-Gx})_;"tڦnRݗ^E~uӆK~6yznvxWd9ps;>ƼL%pr[y:3scۉleZ=\w.y0<5b-BV,sN~6SXɏv~ϗ=xu|'g&^mg.zavڳo4g=##n;\'ir5f4n-6X+Lr;OhZK:wv՜5nӳE-!n E9ܱHSFtW9r5 n) jH4U9K6bDziyx'}Vp<-,2p|S7?8-[igaE_ZF+&;y{\3OzfzޖˍGg0[#}whq?9{ۺs[ř{pz^.s,龜 ,)m5ߓOwooܽw=&Rg,=rR[v)2, 3Q ) '@ F2&xVح&0& @IF@Ud &\$)(@4G `ȉbP  *ؤJ-Ib J @H @!4Q$$HBmE5@t10LU  ($TRBP"&KtrSkyNm1ڀ^]nH)lZLdYQ|pDVIRgeJ27hc` 7M&-@2 #KЀ BDelf臗}cռYY7$CuGy$yܗ|NQalA3^=Tc]~r"xg4ϭbUYe:ZVsxY̽gZͮߙYfs{˅s}~bx.͟;\1x%˳55QQg wk.'7wWO` zz㨽fS&YȋDd8]ǩFH2=O#1B' 0CCÜ\_7g㗦_G-¹iC\đ2>3:.ήW2e0teж\Wؼ9yyd,\ab]EN (HwXqӖh;>\'I|q*ͣVtnq_ 0\k1sʸ7|ǼLSϱqN7yo2nnc/g,ou.&D㎟{V:L^Xt}ZFfMUYwt8Õt.<;^g$]k߾Nkv~gǻ3O_ ͨtMʽT3|fںsQrjTz:D}͇c,|{2Ѿ3go[}KI09f_dʳ6Nh a8D& B$B 2"IVŊO!"抵EB-&Ud H"d4JY@ @@#iP@M9&I8@IPJ  <@Q$0JD(r:6t6D )@GB L" H(4L,:"3.JmDsn#$5ʄsS6ۈe8gִEJN8(/xR4Ԋ1DŽR,Lң@U}W`d)"SLL .H0ZFN%DLy~jp|7ƹ.][SǚdǍWV\+'xWzk)2L)36}8vm,w),scp̧Xw+Nwr^/ $7rXWF',O.?eGd^>w>>o3;VV_9exYsׯ*yƓpyq90tnJD*Iݓq$/o~s!pv5ϊm\FYqQ,B+׉{lN^.s.+? qͪ+saK,Cϓk}/v6pk|Y{8Q\Tt1j&i/v./gvU<|\{O'Op.qѨ\v\r./kn<hƱV*KT;>Dt"&qq9!|mx3oI{)ݞ[:XU=ۓfz#}^ףkjN#{¬s?fe۸y$ZZxVǂȦͰZiÑLJ"L* BH*$t缸7k-B#ez-cݦg{4?%v_7{lٗv2^Fpsǜ[}ꭏ,S3%rw;n'Sy+f{,g~6\9w_aI}辖h5q^5(sr*vYϙ2{[EէcX*՟6>Ϧߥ#;}oر.skԬ%n7a敚,pN'^hYoY_>t&wf5K)LSLb;vOBGO4=+bvy2a=z/ǽ7k'ܲ?kkM4ÖxF֑7+P,$PR'@ SCqB72kv֓Azg9_={;ӤjG8Ã}"e|]C,TtgDq˹<]UȢ33;.s_UG//+5kWk1c>(t_sVYq9Iuqû.SoȾg{o/Rz=]_ΦiDZ>{Q~uW=uLˋ#1äevq;9OGu]v~ɏwyk L- {U)jS)^bJڮj̤ԂrVlD(H$T#L5,rLyw)8r{|oI7㇝l߳y|~`^%OFii9*LFwa(U^feص+rKL'ʌ4Or.{zYoKg ڙǢ;T+Z91]o3G/7p..U۰zIիqc˯:!;6seOCvMSTg2`fcOM\LL06[LE([jڍI S % C * (0HY[ 03S;$d@@$@  A,9Yə!(J$c+S[ܒsYzX$@ ( H@"IFdD #PH"PP(PT,Ra0WHY[ "i0)0,iKDꛭ*IVF-`Qǟ H TTWj-zJLDem>oNM&5-E1 >Wk4M֘Ð2 m 1m<M$ Vc"R @Eܕ@Oy2%.IT(&#KE@i/ STTlW<&QYX -2S( ikrg@Rw)sS,‚5.J\jxT.=Y{o{W&ydOX4^5Cv짦辋ݏ-޹\n˖>RsS\$ 8OZǞ<|nMs\<z{ve4ω'ϖqhQ'kI]q|U\)#oEU|U-#ϴ_.}*C%Ej1.{;"*3z6v:z8[Շo\?n2ض~i;>¾jcrGK߽;=͉; m7-rPuDt9ZhRݽEfb9DyD,n#x\]٦K3M^ևmukYJ^&1QvI4;TY0Ou::tgEvNqm_'I>ͧ^M=ɞ3ގowM9Ko>x.Uvfj39_W:eޏݛV}7+GS=!GYqO$}ػa3K m ˳{Z|/;(>xrrVn3wd՘w.~{<$\.Q #m6KQL"%vj-;FѴ,% $, H(&XC %@TȠ#i*@D @84ka"H  R`Y BqŞ]+$ Jl6AxD3"I@  D ^`rA(AdJ&A m".@.'@ R BA&W ٴE(#iѤP\lvltO=тBW P@b+xME1n)k myyu"0[YLpk0P,' 84""A@4  R䥪QZ(*k@ #M$;lgZTD:HFP)rG|TXx\E^Uqp@J&w%rZ.grҹdڂ>I+]ZyO=rrѥ|4#jk>npxSXB9r ,_(vmh*3ױl޸ :?n콟K|~^,=6z5q{nY>\dlٞrϴւ#ܷkL^͌w|oޯxvG^oIRilFyx[jcg=4Rï}F=>wo(g^ќÇ$۞)Yqm/jiZW3|>ުckO3˯%2c:1`\]ea<_]`W7e׬~f3^iώ8y_+;>#Mnt󫶪}h|cˍ~6~hv\8wWyO_WawǤѷh9TDj-M3GOv}1sj'(u}!Wy/+a!W]<]ovsz =v|_UzUvxGz9C| q;\?a􄓟;y}?}VPm0Sk[%v yJܕ6dTJDi"P*@C $P@**"Ae* J1fF1 "` * e! CP 9H̤|DnVh"*e*&((980F  zr %"],L)2[bY@Q)EkI"خ'w@WD . M-,H6KqF>|kWȘi۵Vy*1džaZi @fE]FWh-6׀K2B_i|`dV4tl -grV䭠Q$0Uص*\j|>7vf~iWGŇrwj陙ǤcvrgFv>Ϭ2OCkp8\{c1I4jEWj\&S&V[w&S&Nx(*dM@d HJ,`% HHa+( *e`  E%"**ȨD H H*D2$g%"DtI<8HRT6diL_JY@"!#8] XBCHbP" @!BA JT9$ J(H%$TI HйC"v("ZX{.&1I]n9j)j!y0ύ:Nѽ"VWVi(QP!5[@EhJMN@&6K-B4ER%A"mWiF!-@HNT۪PYٗ.s -&yٻ4죜\,78S~}th]z]=K7Ys u'n}r^{{+#ύO >/F{v|GCkCiancgi8v!iM1ll莇oISf)V|lJΊ!ڣOjQ3TDsCct34'UF,DǨ[Ov% 1S'8Z*7\bQtEڿb)v0p;m/ݟU96gنq4C>9|}\>͆>&9qrǾgE?qlF]O`=յffx!1g8I$ԞCjڭr+Q]Dȴ%v P @ %@$ T *DQ"P ! JbBQ(Y81H Je2Gux%cHD$X!"&N|I)i.&H 4 0FE$TN(",B%  $J.2Niabj(#dlp*=t]+HDhTA Y #b Z(@$4 "t؉B@ %;F@Ki*T5rU:Ko*96t5t2#=Ѿx7noÇ#qy63.F΃N{ger~hzVx?r͍}>Ct=K:.kIVwnYܕu:Z<;XKiiUt[ט-b4C(_7{;sMx{K~ЙgVvn&}y+xI5f:[yx:ˋ{~:=7SOs9ڟ ):;y~>"/yˏkXcrtۧ;+;{ֿ!x.31ymwmI^S8S@GՎk?oe=켹s{*Q2/1FڻẂF׹+rTȶ H  "ebD$@ 0P , @"$IQ"Y@%&Bj\$@I0TY%x&S @![*"ȑMM@<EJ^hP B@B@D H!"R L `OT[ O3@z/ԀH hQBQAQQ]4ҺV HH(6j@ͪ%)B@3S֒ӫD%qo 9׃۽)׈˒Wl޷cgDt':\ ^WlsWuvJ>7|g,٫Ȏg@YtvJ.[9y2^eOB΂#;tiirLZg&`SoImΦf1eMOo=ٔg&q Y.zIիgvyݢff#mʴ;;15UKdݡ3rb:˪s3v?Rgu>۝Ώ\ {I'iǡ_9|iju3zUw2cH,pgzDq3\lcE=EH;_n򸝧,=Cα;t=z=5G}AD3Js[R&j.cխ >3rή6cVԿu=<+x1K>=]=%{'fٺfM'kk5OK-^4;|Qa.-ǽnzDexzx|<8sXE廨溦\B6o?{$gz Q([hڛEUGy]0 !IH@ D ̋(&0!"*$Ve@P*,$* Bt$@ )3Hȳ 1 qEI BPe4c!"I)*1TjNb  r ̴U  (Ii%"4%(A@E@@@ x",OD^b9(m4,+`@zOm(Hh44$PP@(D*TI(%3.Z,MDԚKv x.emMN+kK[.&8sv6<.S^lq37}$7n֏-i{ݭ/pU=(zsl{635/1uaQ#y;,匵c8H5ݐuS*U|fruѝg f\KOch&E*mj;Fյ e[BT$B  (H!"TJD$dY E$$TH+R `p  @"V(`J51e" I&dJ08\JR9NL`.%,C&N i E@Ii%2 E@ $"D$*JEj@A2Fpap`@z/ȐP P 1ET>ux\no8:hsSCTWԄO^7[|N6Znݷ=4O52m>/h|\N3'r-ٙvu[f!ҿgЦ7"N3ψ=2㍷t/\[ݞNS6Gurƞ&"Tq|eG */k,^뻅yGbSqu=]V߽{xWrf{1N\qgDp8zˍz')^fǻc%R7 &bߋ_YY\C~MrmFykecγƺMݪrGwjyW}&2Ӹf~ykл)VSXf*\^]٩宓Lv^<:mffr-"WÇ5y]j&DEhِНh *0*$4PlH  @B@@ @D @( H`$Ae*& $B@"J$HH @e8H( @ BA$*Da;B*F DDY@ (ITv^TsAp V(A A0g ѣH , J4؁(CJ^i(2,==H>'G˟i0B4~/hgl3ZrPȴŦY|e>|asbˊ7oD򍲬r0[n7ټ]|||N#4 觜RumӉ|8|N-3oS^ĺO7zuꮪ$^'wWSbq?8>u\,/ږvO2?gU LPЀ) U%"%Q0 TT @ !"HJ4D @P IH**!P  H4i9GT,"L$CSI@BFF P"5)+!PG(D` E'4E:zb`@EL$FHOq)P@H$DX(LE9thC3zqwOZp|zz<18˝zH&sHG kFiTZA(@ VLPUDP@HHEDP `9 %*"(@  IL@@!(@P$HȨD$@JED@ g(@$BT2 P$IEIHBEH#]$i:)'HTHH  >stream Adobed     '$''''$25552;;;;;;;;;;   ####''',,,   ####''',,,   ####''',,, ""   !1A"Qq #$%&'()*23456789:BCDEFGHIJRSTUVWXYZabcdefghijrstuvwxyz!1AQqa "#$%&'()*23456789:BCDEFGHIJRSTUVWXYZbcdefghijrstuvwxyz?F  at* ,SP p"YB!20 B)HU(Q #LheU -DLR&u*fc#!(*AJ̭2HKD(Ɋb*b((Ȣ3-EFEDмaW,a a#DÑhE0%A:01FIZ 1 d6*P,ӥ%DTeEMDA1(*0Ud62%! fS„ArUM,I@ TiVVDFA@2F#EgHAp23eg2*T`ѶKt5^l (P$R9)5 ؐbZER ZB)Ԭ!Y#uMj$ %2#'T׈RaBSE7TcI3#PZuUX! *1!ucRWNTx(dj#IWT\A5R&6IUŀ뫫%VPhP3""DjVdj2lI2ffKH1F,*0 9W)D& UKDdnbM'\mΫY ,B RARjB)m,BE$R%C$N*ntb1pW@D Zb'MUkM^!MEE14[D$i0i%L"KjH)6H Y2"ɒJ1TI% % 2,&,h&dҐ2I#,:(0`Kb "'+FHp"€ & 8.ӓ(H1CXbLčn]JbEա\Op)L&BƵ) hCZ542P1=GR Zڑļ2U -қ(7T*PaXHPaAEf$]0@ܞ D,aVWDREUA% &+e&Q$H$,ZcPMbE ,[#U 9iA9tHF Ul޸*+(*Fr *UR 7R( IQDH1 TU(nU++ čfEEGY%{"IZ3`2j%r""hj*LD2 ȤAq40#B(F(6%u\8B.&DCeLSXkWeRvdhEAbNf.'Y3T ɷS,05u2ʳ cP Q %P0]F1R Cc%4IsMbF MW!HcH`±R&{*t$Dʴ(h5FђMe'Y$FAnbHjI3R22YC<RTPxeq0jH!3SQ=Z |80Bh@W(YTXՀ Z+d( -ТZM3~d- ȲfEjXRAka 1h.u'$1U©A RB{&d7 l$Ub.\A$3i @B0ַ jH0 ԗ/'jd]5Or5(0]ÐYxFKhMzRC {e#EHUUڃ""i:L1q3Qu^bT4 8ٞ:Ą9MfzuA$U 0rʒBlLpDNdɷ (5C쁠h4KFхn6!-xSхr TE!(a ,ӢJ`j'Jm7"iɤ3Qjʷz&n5eT/kSnUHU[1-:P]ISԕ<"*7%HDBdS'! `Z'vWRnPj2$)u0.H*6R f d6(Ćyr*ʔ?ZfjKe$*ae $V&Ն4 `A0`ILH58O.@%H*bXICPDP#݊)-آQ+qR PBԺQ1T2XV,$T(![F0,aD0;UATigDe95$%-1TE)U`HB8102D1ʬIh*Y0fL"NFh,T FEB h&W"JI#&F/ܺIwTH5*C).$@2l&*QՐJ "xr 0Be$vlH:Ȓ&i$EDPt+BDN*1:QT45 "54ɈS4LE3TJ`LM%BPQжsԶsӗPռJb4 1 LĴX$d/1Y2D"aDJA!Œ* bPu I ` Y)QdR ]f#&RED((Uf+HJB*VQ7YCh 6jR\*jHM=iFhN ",(05XfMq)@QVЖԂHDHP:J"f` ]5T0ףDdPPA@ vF*`((ȅΨeB`Sq XBIs`TJUb'VBH%/D@ʤD)r!@3%2+-!R KEŽ4TQAx&x!܀ %%6XDrPQb5ȑ*C*+DV#(UJaEAEװb dVHa&HT"PV!x(K9!Nꀠ` x$(QLDgT*##@IVM V d1!DNaXD(QE+ *AC$DQ2P ,X)kQ0DBJFKD2Z `@P  endstream endobj 3000 0 obj <>stream Adobed     '$''''$25552;;;;;;;;;;   ####''',,,   ####''',,,   ####''',,,""   }!1Q2ARa"BCTbq$3Sc #%&'()*456789:DEFGHIJUVWXYZdefghijrstuvwxyz !1AQaq"2BRSbr #$%&'()*3456789:CDEFGHIJTUVWXYZcdefghijstuvwxyz?b?,s[9NaC! phA@r)WzqNyL֩U QMJ.AFY)ߖ9A PPQR*!vYNztU-T jQR(a95LMB Z+K9_9MpRBHQ B#IH$稙JSR@Ԉ)Ga)!ZAhB J0B jD JTBNzj:PqISHAD_9&S;Q JԡBsIM]$W2jdPB*)~ I ƠcPBNz{P .PB))*ʐ}GjFT-Њ$u\ɦY`Ytdfsêk+6Qk^E㷽U{#zF#u#{ T`Mn2LVɸbwZ}X@X=]"z(m$q[/[L3yYY[M&qcLqQ7=al. 1;Iڕd" (2Vְ]hl_;6Sڐgs烎9%F(H#PWUB(VH:=3 AQ*A'<14 ()RTC/x9\B}(*5]Xnq9]DpSB5 AKAB8 q\0؆cltxU! F,2ً^ÆCE[VٸFS*tj 휶'͊k+ĔZi$+Bf`H9 ۠lVúp?(v#At9}af86f9/殌L`_uzHvE|mE&GO}]X .&!Uk%xP5!AA*Bp9G *&C.C9r(*:D7M*#AHRpV ht^0ԭ)o5@d!mj\.EL)V*Q $& Fi)BTP$8j(D1(B%JU%HPQ7ӂ++(ROY0L!V%HJ"H*@XUJJdfT(A*BY*m6(PQV*R)j)QUZJ2SB)B NuLj5HB&T̠V42RP[UR++?\1_68f&&Y`Nf{{W @G7ǰHI咸_-(B .ԍҘ(R @ rS^N2VRХ@W< *MHREE!8(ȡ<̩J+Ut , * q LSFSּFǐ+r-iZÆֺ5'9;!$́A0nJ+j%^[/Q{O u`7ʰ3O=lH9*İѬcCsQ(mH2!NHޙgj@FqؼG2Z_^AXtqH; Jܫ+aH V.9b๔F4W'Vz&Ŷ"F a`oQxLX?Ss?Ng3lmx|C06AHѬA 5hl7"%s%|Y+3,(j#KgAvhn):٩ QYU¼ѾLJh"#? Yk\+_aڎõtCri< V]YeJln1HZA!Ob! YDYNХ4 |!JH9-BYEeJEEĴMi'*Xi6==\+6C~fPRG ^,}3*ʧV=="@) V Xo0p(Gbl{DQy^TdoM׹G(nXX^eAQ~ϺA;ꮢoVA-4 #tBXXJ>=}z *Κt bM9zhEpEwQ";quJˈ1: 훛|9(lBpVj蠨XAxtRtGwPF # 惘=P) &cV rJ&JN)Q"\d;d ȂUh1p腕 OaAAуqhDWJsoӠ[IN _ds脐LlbFSiNa\cbxstO7m.0,kY4 Ka }%{yRym^͟4t{0Z] hThHp tro!leu%ıuz{@M#gJ4xA'<^2H3tZÖ9_.ZuJ}?GцeohֶC3LлibfZ=n d2x"qa @!5.AJ4ZA4 ^ Z (k4u*ih#xGp$(I"PC@ )B:٨Du(8ӳBKDxܮDҎ.'x>' >KTQʲWWI|w`s*;hs+k e<.a,Z6m:LYX9P7+s|u%WMb;&WN3G0&JS]A|n} QۗIzkřhD-T} Z{PYJ!Q=r: 1t=5t꯺n10ir#=>h ;DӍ)^: ;rQۛH\.qoo|E ;z8GS$ 2'./{r:hˤwP鮂m4ܭ;RΓ,IUa bscbsNV|S)/QbGUHq=: q=:j{pG1_pt vH%[?F47_ 5k#%D- ViТP_?]wL+87^⧂vNwDPҪgnRUQreLa7U$(:/ܡ|wpT,c/k^{4=w$U@ȄA1),1bhL " sc"GkHklyػNG r/P+{Jj/(GeRDFʄDkK$WJzCVdXĘʖ3W($I$+iF[`xQ٘5 ƀۖ&NsE2jQs+hW11=tR^bӠ [iq,m8]fvm 蚭HRy7szMh*u`ƍ*l TR'=5w)V"N^ :#zsI7d=zJ.Cz*-t[5J,9FvlI;EULuz+1tc B! /d.RӽטqTEH"󵞊۷DQ۷DVB{'16▝ۊ:gv;ނ;voAlD+vzn)d.UD\nEk=nݖtۻD: Z;Y-zd.Q$]nEk=vݖt;΂ԅoNK^bM[%1vh"u/Y謽N쳠'vY R:YyE-:YyEUI#}Eeߢwa {wgB҅kNvG^bKNvC^bUREH"ۿD>ۿDşBҥ-6J$g`sUXtRu#PZ8dιIдf[bu-! jQ23բ6 }Ъ%nM-8LھwMhd+ /p+Ʒ`28#p ]E&}l.>D %ڐ$8^u{@LJrau:VbRLkC SN$oyK P))܂J*1jj""Zq jAVP࠵1lQZbb4)Jp(qE:*\TG[ Z}FhUP\+: $T<D&JGP4IRCN!'4:-52VȆ@k@`r X*Uuȴ:>v+RVuypPkq0]͗9 :  {]Y;Gu`fkb1|4-j2I:6`";c[CfpMb/s%@{ ;+w1gҞK44^ i%SKK` l^"ӧpE.v&)9VC qB.$6c!`%7y&_!U30FTF:7 &W3.9  b.63v'f $ e}0h%횇"`1δpŜzucaJJ/BTَO<ܗ*ܩ6OpjM8VDǪ'LHP)BHI P!  !*2JI2J!Jy%BI2J !$IPI$B)BI$B!$I B!1C8BqrVb܋;VV 7b _Vpt:^+K^>yU8[ WBQM&Dd֤fb<6T;()OZ@ܕkRv!kWMZ5YY8蕋Jۃ5֯lhu-"5tMV+-aj$6'JIUBCУ"$BmAIVd4nR0R&]Qf&'I2JKL,LJJvJ`j&U(wJkgHne8(yMDB{^2@)&SHM`@h7Z(lVoQ쯚R<iCAD KiVR_l~ س[hGxقb g;䪚Mal-mls|^6L^x7A'q ;j-3Aoh1/fXYl<& #ÃY 44l07 R? C'g KB@]Kf6R\^+QT)ґmenسL[# 87g?\+z%YnjvvA}l68ؼb24k>=RͤZl`=f;%Jt*33 PM8[]TRl-m]26onIzZ8-mͶg yj-*,1p"0_ߢXGױ<UE{5ϴ7E}fHsZ#|ݼ4Cg,ݴv|54|W'ҵƍJw.i):}`E;EϴVvq;&MW%xisҖL7tFCisA ]x7VeurEJDhodKќ醽߲ w|Ѷ. sX$ N`_. GNdi"ɃF.˹K병" iԱp.'fd 8j,`AUeЭ8ŭ';2Ypl2ϺK%XsSCVWK[;1/{Z5:kyڂ+wni=hV]mhx=Pq15ݒ\ᢜhP1 JlU{2Qw&C-F `=dܚ ;~$s2[=Xs7GOd+Ae DvFG/9AZe `ց&[:ʬ:.;U7-N.k{IWi ہJk1b=zjn 1.꒜ֵj.G"9 ک0*4FbqI4iE[lwq<VI93K歩ZS=huⶖF']A ;UNVub4vxܩ2->;ȍ3UgѢusUФl=y0v6o6ݛxNAl<7KN+ͳu78f(hX I& fR!5# , p҈)$⚅%;ŭ#^dwERٶ*׌XPՔʆJ;x'58-N<{IAMp۞f CKa5N{[6snG$nx.p;s|4l{vKtt^̀ӕ+#RbU&Q.]th&m7rU[!h X$iM;5&!Z.I4Қ*VN4ġ PETJrU=I JsF +8'P+&k QDj#T!k,GI&Jj R˜I1Jj.71fڅmxcyόjXF6.͂yUcm[6:=X ``sF~ܥenw>_ztWhss8^{Oҭ5 -%juCzs(aOUa^UPEҺ6IDvbKݤQ;*N⥦z-57GauXAy9jE(l;4C{˵_q jgdf|hz<Iz4 9ƧRaEs@p"4!J 4ɃhNS(:)q#')tXnguWOkX0k,{Dls#eKz 3݉:_:-/ofA m .4scykBiw^o oc]1F^.HʪM&+f8x%DJ `-tSW:e3mB} E;** |ZmT%QELLXQ Wafz QAuRu\*ds!WfdT&1*"ֺ\<:m6x2NV^\Asp#fN tCiJ(W%濬=tۥv;e1\jŇcu&Znp{UbظE-Ia\: %T:-n`zjC훃ELv 62$l.iKRZP Иp=%#J\sBbgz]i1Tx(Nn/]\) pd1 U[i#U2rp杠ŠjYnl?MQ7(sVL^;k",7A%t{uE{;|u(ƥ-2S289GOW{&6nɛ4ZgD'Xŷ{{\ԣxdȂi/K/-CZvwT GABu!amn;Tg5/F˛Vl9MN G `ׁM9upjEѨ Ҭ% nZ_T[ 6bJ~=v̒ ggD8N }MFRF澃jM[0F^hm_jDp.w1Nd-'hJU/.C, G! ƤSL "SY2JPYvz >1 `ڮ ! i8"ٖbjN T8*5@JI"EGJURS(HBhBd('B-TLJ*BƔG1@'*ōRśԬ M8k B&N%MK6RSOY*)((O T&sQLcE A)<8;qzB]+C6pzGXHB&sdm0N]]*u'l+EY,2a.C cz\CiDambf4eGwtkNi¹Ҭ //+h. *]͝CEUT^G`-:[ѣ0^jڢ8qH8eߥt‰ad+z0Sq,qycḚzU>tJ;KgYg땷u"+A'O"W^ c+m ztfsC|4lZAsEK;;FI5҇rْ$8w5ojv6M sE\Iqdv|4j#cyA> )|Vckho&,mŚNѵi-uf\`Fظf9CE֮< =ƒKJ9hk"WsRpU mV>c=2Ax-+eK=3EڍI敏4i/&Ap v#퉷 !.Bk_87H<m,8¥ehpiWN4#:ǓxnrF41s~+vytQbH[  T'}5z$hKTpX=yly!8s[Ghr 10SmQAٖ͕+ekMXZ «d+I,KzN[[ p^J-m,$">6PBRČx' s-iT1'8Qdv)Y첼6Zm9T l7Xca-:+e5t<\;vako6Z؂6Aa8C0b7 TD;%x\3 d6CFMВZhy%B+G3-&R4gZ󖅻D8_BR&֐ZvD!dh#e#hWfm!xb1AuKw0;hov5[*¦)V9f4 cz4sQqY޼zJ}11Krz 0jQxRQj83XivGKA`C0_*ԭ9ͦjV> Gb컫yx ^?'Qi*aJJidBU(YQL]Jgmݗ|FN )j^Ʒ&yFǡŌ0au8HOdM4MLuHEVN7Z6L6 1Td(1;nZ zPP#i-3G-4;*ͥڞ 緶){nbs0d!e tWt8WQpKze Rt És]:5u NzنqY3/7%90  0_ޫȊUɍbB}gNҢ%O#kHH ^B+Cgt.nV^ I厬)9̷{0'd >F=0P ŭfaM S13gUM9#U=cN#g mL*Xv-sLuJFg]M\:9,HfOcsBi\9 @ATR$TK(/- \/pWp-5W{ 掔-I޲H9"#Ŀ Uz4XD[w p~=DZd,W+3Hgv&{$i$RVΑg-|/:ф9z6B+ltqX23tkT:SKJUb+9c=FhFD "4nuB@CMCǷqOs4)nI6i=BƕZ98aӲ@=Xj2!/K`m6LM"☋ <1X0 $aUFH s,݁ڕә+iGS80 ,Il$ѢHԂ,3{xGئ])͖Z* &Pm5v%+Us#cwlݐN̓m ;]'{j.u&R#8t5gIsOQ:;P6HقW^4mWi(4"TJ$Z[bL.ol[4iXhy{- 0GAV}@gn-:Je6 юfW=Mh{s ]".S9ݵu-uAB_2*ɶ:%kjߋG"๔ E"11@lAHmteXƂ洶C.Kop^}@m%D^+]+ȱndsų[ƄI'O}1گq捨x`f^sciTla+G {Hfa`SJQL68E ~\ d hPqNAR8bku G_qeYP'D"o H"5+7p~*K@*(؋ȡV*VU9-60Zy U?Dvf\Y}V]d80i@u<31ƸdE`9xY僺ճ<} WC#Qn5P ؁eea \Av % =%AϷhӺҹgi/ќ8-/=5 :Ӻzb͵fUݦZN)E$Eꚤ?G)YNSe(WnОHJ*҈PRRI:"T^U&)$B`JQbI2 K2UHS(KU-*BrfI$ `` i`݊wO/5!XfDs(,l +zCnkFX3d\uV4igd=2MXeiU^D)V)V*)(B_,ĦoC"7Su&e0ىiV !rrd McQ v͹i9[ԃFe Z9MFY!ҒAk_Jo؞ 6ꯓtiOx$ fg W1#N`Si`ʘX()V.heT!ᥝslɪ9M탔),xl3%qd=z Yj̘é =.9M2DEVF]¸\1ӺaCOrӺAhйIsvF 8k=aC 3ch2:#Kvd;a] 5-E經ߧ[%|i=Leo7 gmf,)aUSl5* ++mrV";߯zPGtS{=7GeZiqUԎYW('vbw C5.A+mB6,̜PŐ/uTk~^7\Dj^NYic T"cp/ f ӏ@עG lh1- ыe+W B)NiID6BD! j@Z6HV  476JUeYJ`PۓPX n(ViH*r RUAbAadL (@ڬ&* F1`NCô]= y7ZvEpr "FX`kҼ뻨)-)o͵ٟ}H m#01h'kViQx슥  Hq70.ȴ29!ڳvj ؀7kh/ I7`MeR>̃V\ϖ!D',b!lm)yMi4AH*eHW栔 R *<.Sl@R R R@>ͪKgeBUQNTƵ`Ð+W .Ո4f؋>*Qj tiYLm<[4GEXZqA!2)jbazmxW6؄[CINRB rRBK.(J#\&qQ τ UXptAq@S#X4#4Bţ@0_n9_Pm6<0 fv`TEu*2(A h[y;g u)"TJBԊ,2ASO!1j' ,5m$K r}6d,\ahЃGJqmjsCBP!Z`:rj2Ŏ<袋=5N&۴CHhui9)pu/慿lcef@\$zlMG'xۜ 8!D +i<46δ6WC8mVI5)[u*{orq){D(z +4HS' )nqƒs^ދAiY6̲os^ǤPɻQ+oh)i3BUDwCzWw;?&{ݟ|!rtb͊ΥH$B$*[cf!>ݞ=3gJ}, HLZ/! @ B`VR U6\*MlE*IJA*%C'0PB*({ Ѐ Wj+nySVBP<.*@ u F %"ل228e ZJ"M͚R 4BRJvfWNL F!kfn`+œ8FF@;8V[F*0΂;ʂW MtlE ߐ]va{WA)vkIQ+ Vغ+.9E&XYY ^KCm%y-|ĺ;B*2 hlʌ0Ҝ0´ckC/s^vUJ Av9;@D}`l+.&"/r6Ѽ7hvx[?UdJE_vmЪD ]V 8Y9U6VoŃH^ΏCYyh:/JǶB1;zK%J:Gi"^9iIMtK-G3B>bGdy0BϲRn7fB €gFQAs(w,2׶Eo:?Z{8^}m3"6Hv甪c0(9*AsmH!Ѫ,#Ua{^k&KG"xAEJ!p-#zݜG;9wO;cU; e{6oEOo+7YBϚ,lHQcNUruݱHlk4l;ފ JEmDhORj )=7| ,8^aD…do9L AH5 M2B eAE`R|ҥ} gR)(ApLĔ@(V+( HRR pBQ( TY)'ʕ2$%7T U@*A18(*!LHI@sR B! l(*%JfAGp@xR 1IT *mJ#AQk4*U (! d)#=7\MSRiLNhM5NJ`;Er^D5*&"l&5!J,g"UP%)&ShB VP 5 c0o!MB2UJMtћ,^Si*T8 (GTq !DC7T!X)R)L2BRL0"a B)^G,nhP:Uʐ.-O$% SNqB*em9I4;I *T =Bv*)Z4 . "!-ҡBNi(.aUVU* ztM¤ XXWPQ%q@*b򁾄U8RJD(B]B*m3BBF*aeHd!D*rN*P4'Y\CS( U$f!`jWPUeLT0:^B*%1( vBͪD<ͪ.MpJ~)Kx" endstream endobj 3001 0 obj <>stream Adobed     '$''''$25552;;;;;;;;;;   ####''',,,   ####''',,,   ####''',,, ""  1Aq !"#$%&'()*23456789:BCDEFGHIJQRSTUVWXYZabcdefghijrstuvwxyz!1QAaq "#$%&'()*23456789:BCDEFGHIJRSTUVWXYZbcdefghijrstuvwxyz?BSX:*brS ĂJYU+TjBu*ka12(!R:Pa@B*$Qo(MFAհ*KY*S191Db DT%G*fkA!~EE&$(j$q2$1?BFWD̐~4DkXz$GU@!uH+ 5h?F9# \5 e ԁ%мH`# J±J2HJ Ɖ,# Q@IA.0HD$32~E%(Q iDeEb1L (RFbD̟$kMC(ऄC!!IP$FihPĺiOъ& P7 h@.0T\O~ 24Q.D $B2 # F @BS!A 2N ٠d9h"u !ƊcBT DAPP:!@TQC Y)3"Y_k%E(ME a1, XPt,rP$]!i**:h)pu33bj PQ5$#0Fi"fiL"E*K$i"HDb2 #M&Éf5H¸hL!$%J&Q셄Q%EYԌPa(a "fA؈ĒDc@h]`%eyBEH#6_mUm@̩\M!5U237 ZP=\ت(g1LȮ05q'jzER/mT͵Hؒ#dO ڷ6MHR~$k"D,DBe5TTM٤DMAwU Ζc1C.2(8W$1bIT:H\IF$2$AEJ"L¬UM fJ $K#QTp$"fPa@j `CQ 3oM "q =%eGP! Q"`B{TÁpQ"AB@eaA"Y(pTLH$%B"TLBPEQwpȩ=ld`JKD, )FbARM%eEdHߋLkjIjnf"d*8pH8&Ab&Riaj@R<,) T CL NiVW2KPBhaJ(Z3W"ߒiOU4k ZMD 'A' ##TEM"jF`h&WPe*H@5dՋ "5,JA"se7 a%Rt"FTR) aSL"" ( rӼh$fmdP3f%%2[DR*)J($an Oȗ1lHNE6%mޅdBZjK!*7xA]")OeDd_*iLI2"ˉpt~ HDieES\lZ!\]R:aTȫ0\YUJf)0?H%*SRS$\,]$#2ݸRFl K7jH)?D~ KF*2^4D08&\*P*Qx55SЉ"f!԰Id /*p!1"'eXHdԒXJbL3AMIg,sFd+`!\q*38QR!ЅqŒpW pM1: 'Rp8/i&m$ *+0%K"MfŒ!ar]!.\  RC  "c:TW\.XP`% : û(PI0 †h  3+A/S `W!(( ĨdRDHk))E53[|#4LՍךXDn ,!$TQԷM!f%Ե(sHV 84R 0%Յ3%DWDMđIU#I$ͼrcEqH7wh",) MR4"iP)E"2ʎpTpR2ܐa*" *)uA=@S"DS`dbh@$t:XMY4ٛ!g4U & Re$C$d`KB(I@#I"(%*(bWSbf#iCU( **BXd%#2&Bh4 f̂@&QNѠ.@˙](QWD&U4IƤ3dDAuȣ%-UѡD걒 .&4`XGQՠơULĉ1"~u%նJAer2jrh (nr!H%4ԮaXv"\:&@Sw)MDrhKH m] TE"&DU&%!q\$0*DșT6RU9YPR0t*%5D?$đEYPMB5ن3\3 kv!Ur"fFcYgE߯W%QP&Aa"AR"j,"JQ.AJ/đ~UPBHژ,f $. 8`AR)$f!4 H:ZLa*S 3jAL1(8IwaAP:$5))@H!@IPqT$+LJN@f"EEL +!CuYR cR2j#&!HD$ɚ$! *2VLx + T j!MQ3b&W 4j7O`D qkX,@:1 *5Frה&`0AU&I)(RHc AQ3 RN$%""\(J]Y VK# " JRB0X)3  c21R"D0EED$D$H!JpJ p10ٌ6b"   endstream endobj 3002 0 obj <>stream Adobed     '$''''$25552;;;;;;;;;;   ####''',,,   ####''',,,   ####''',,, ""  W=!1A"Qaq #$%&'()*23456789:BCDEFGHIJRSTUVWXYZbcdefghijrstuvwxyz!1AQaq"B #$%&'()*23456789:CDEFGHIJRSTUVWXYZbcdefghijrstuvwxyz?[ H$dn bF ^X-R"K! Meصe1DYb4`!)YREᱢo",LtF[H$ΔA $3#E\1C% $ISiLIh(2\H(ۤWa"\JLu/YD44%J%4"v) 6 #!MfI0KJ|$aI5f >@n1ŀI(qMM,*,Y$: Fcaff#F 2ZI܁ @ $Xb(z m@јS(Rۏ*1ic3 R DdOFD2Zyn!,&U SdEI7 k cpxg"H%N-\FMH rK\* T@ꥸ2hY4B% F.Ul``AdIFnP@͙G_XlfDc(@;%5dYOE"y"Q,&S f%R .TAT *uռ{hH*M%H$N{ck]]Hhr&JR%e#ڹ&Kqb4MF،l,Ir$%-K 5n5 LJ$R Is.LbiК)%:)e(rPBK7rK6AT#Xrìַx-$DǡVHRB‘QfFbK9"`ʓCP(2I/yss6Í,qbhhўdɝѭD9l!H߸*abZ.= K,ɗ)Q##X$X" Hm32 l<(Gf@y-m j2Ih$PZ̪T_Ċ"Ɗ("JETBE VWR~DO(%P9E |v`.cVB%DlA&2d@8CYuoX[ fPAF@(6D#QCIMeB(87:Dy!C‰ ȓ(HE*p(Re fWQd[JL $i RJp_0Rn$#uF.0&)(CLh&e"e•L*S]ɫ;dQB܀$"ң#Ý =Ms3Ө T*E!]Rĩ%)2WYi 5g Lgc9r D=zdM)FƝ71[" I"k#% 2!D\(y2.Vsԉ anLdD'1$63[ .,Ȕ $I RAb2uoP+ # IY k8D:' !hf cbBT]p>) !5[dQd>(2IR,7:tE Iu̬[*ȭfp(̍b^ }FPV0 q@jksJG19䴀s` )[q\D 2%3eeJeDOg4ӡ,&d>I7iC+#$IhHfD#ͨK 4$@Y@ XNl*aS "MIeaDANte2. V$ҀH%7*p-d-Z B-"R*Jd:")&(5*ȸS2Y6663MId7% D KJ,Hɔ @JMD(6 &tIJMwX*5})pf1aƞ*0fi,d:8 l l-&4Ld&gB&I)e<|$Th ytI29Au3p PfoP2 $I"FoQqp0ETh7$GIr"R-‘ 2r˒-Δd"\[) ۙl<ؙ &Dx*ItH̒E "[A@aqndh p$J%$DJ1hcM$tF2+S! BxrJ IL"27(e&Kɴe*-vQ JVk 7F}Ш'Ji !e 3bhbd4шH'!|IgI)aRPqۆ]L$ɞ06m$PāT)dYT8 Xd$ PĤR63F"4 %6%X$>Iq_H*J+U tv#6d]6t "$VN 4ntN`,2$FRԠ3sImR~d5)H%ɪVUne "hcKCD*ĚrRɺ}TFDI]q|9eT d[{ %VS؜A$I2!~BvDPK R.%U#1 ̡Hp5d)7CSzaI`X u nm <ġ&ܺB1 57:LCV0Tnэfh5I}I/`Q$0j)1+c*Bʐȗ Vz)loI d[ZT QyT$Al➅#A3@6D)x | D37!A H" Z& reҽQPHLmYb;q7P,R, ,pbPHZZעsI؀,Aϗtr MH$X+rDUVn" ,)$B5)Rh>$bj7" ua)$FSIoB7Tܪ CrhrB.DF " -ECFV 7&DYFN2tq@Z7.L `dBZ,#$LF5{E{.UHi*$D֑ dd@&rɕ$&S,4Xa$#Q F#F,!2Uj3~LBBLq V T:h$P46ԤFaI$LpMF-bI-xZi,a$`"s>CF2 :aQMMrܩ%1^$ 4d)e  7Zfb3hC $D hwK4Ce,"p$^I#1Ē3Zѹi..e J ׄ d b-eI |D% MPbj-`4aFl1z8bښRB%f1EX l h0N[jb$ H0aikcrhRC$7"c88)44` endstream endobj 3003 0 obj <>stream AdobedC     '$''''$25552;;;;;;;;;;   !"#$%&'()*123456789:ABCDEFGHIJQRSTUVWXYZabcdefghijqrstuvwxyz?ЪѪҪӪԪժ֪תЪѪҪӪԪժ֪ת endstream endobj 3004 0 obj <>stream AdobedC     '$''''$25552;;;;;;;;;;   !"#$%&'()*123456789:ABCDEFGHIJQRSTUVWXYZabcdefghijqrstuvwxyz?ЪѪҪӪԪժ֪תЪѪҪӪԪժ֪ת endstream endobj 3005 0 obj <>stream AdobedC     '$''''$25552;;;;;;;;;;6  ^C !"#$%&'()*123456789:ABCDEFGHIJQRSTUVWXYZabcdefghijqrstuvwxyz?ЪѪҪӪԪժ֪תЪѪҪӪԪժ֪תЪѪҪӪԪժ֪תЪѪҪӪԪժ֪ endstream endobj 3006 0 obj <>stream AdobedC     '$''''$25552;;;;;;;;;;   !"#$%&'()*123456789:ABCDEFGHIJQRSTUVWXYZabcdefghijqrstuvwxyz?ЪѪҪӪԪժ֪תЪѪҪӪԪժ֪ת endstream endobj 3007 0 obj <>stream AdobedC    ' "'''''",////,7;;;7;;;;;;;;;; IC ^C !"#$%&'()*123456789:ABCDEFGHIJQRSTUVWXYZabcdefghijqrstuvwxyz?ЪѪҪӪԪժ֪תЪѪҪӪԪժ֪תЪѪҪӪԪժ֪תЪѪҪӪԪժ֪תЪѪҪӪԪժ֪תЪѪҪӪԪժ֪תЪѪҪӪԪժ֪תЪѪҪӪԪժ֪תЪѪҪӪԪժ֪תЪѪҪӪԪժ֪תЪѪҪӪԪժ֪תЪѪҪӪԪժ֪תЪѪҪӪԪժ֪תЪѪҪӪԪժ֪תЪѪҪӪԪժ֪תЪѪҪӪԪժ֪תЪѪҪӪԪժ֪תЪ endstream endobj 3008 0 obj <> endobj 3009 0 obj <> endobj 3010 0 obj <> endobj 3011 0 obj <> endobj 3012 0 obj <> endobj 3013 0 obj <> endobj 3014 0 obj <> endobj 3015 0 obj <> endobj 3016 0 obj <> endobj 3017 0 obj <> endobj 3018 0 obj <> endobj 3019 0 obj <> endobj 3020 0 obj <> endobj 3021 0 obj <> endobj 3022 0 obj <> endobj 3023 0 obj <>stream H *Dqw_=f0sp iJRR$4Ij$$))IJ5!gEx?z@~h4!t=Y4| y[gxU<(YC}Ntp\YpND`UG-vvlFr'%MVٕ&'˴D 40,̈́i %lPLп~=R endstream endobj 3024 0 obj <> endobj 3025 0 obj <>stream 2024-01-19T11:35:51+06:00 Adobe Illustrator CS6 (Windows) 2024-01-19T11:35:51+05:00 2024-01-19T11:35:51+05:00 Adobe PDF library 10.01 application/pdf ainot Endomed_200x280_Jan2024 1 True True 199.999851 280.000136 Millimeters Cyan Magenta Yellow Black Default Swatch Group 0 C=0 M=0 Y=0 K=71 PROCESS 100.000000 CMYK 0.000000 0.000000 0.000000 71.000000 C=0 M=0 Y=0 K=100 CMYK PROCESS 0.000000 0.000000 0.000000 100.000000 C=80 M=58 Y=34 K=26 PROCESS 100.000000 CMYK 79.799995 58.499996 34.399998 26.199997 C=0 M=0 Y=0 K=0 CMYK PROCESS 0.000000 0.000000 0.000000 0.000000 C=9 M=93 Y=84 K=1 PROCESS 100.000000 CMYK 9.299999 92.799995 84.199997 1.499999 C=7 M=5 Y=4 K=0 PROCESS 100.000000 CMYK 7.499999 4.799998 3.700000 0.199997 C=92 M=31 Y=3 K=0 PROCESS 100.000000 CMYK 92.446800 30.832397 2.673382 0.296026 C=66 M=10 Y=1 K=0 PROCESS 100.000000 CMYK 65.889999 10.250998 1.324481 0.125122 C=66 M=11 Y=1 K=0 PROCESS 100.000000 CMYK 65.500000 10.899997 1.200002 0.099999 C=0 M=0 Y=0 K=0 PROCESS 100.000000 CMYK 0.400001 0.300002 0.199997 0.000000 C=92 M=31 Y=3 K=0 2 PROCESS 100.000000 CMYK 92.400002 30.799997 2.700001 0.300002 C=0 M=0 Y=0 K=70 PROCESS 100.000000 CMYK 0.000000 0.000000 0.000000 70.000000 C=46 M=34 Y=32 K=17 PROCESS 100.000000 CMYK 46.200001 34.000004 32.400002 17.199999 C=0 M=0 Y=0 K=33 PROCESS 100.000000 CMYK 0.000000 0.000000 0.000000 33.000000 C=0 M=0 Y=0 K=85 PROCESS 100.000000 CMYK 0.000000 0.000000 0.000000 85.000000 C=82 M=59 Y=31 K=20 PROCESS 100.000000 CMYK 81.599998 59.200001 31.099998 19.999998 C=6 M=49 Y=87 K=1 PROCESS 100.000000 CMYK 6.000000 48.599998 86.500000 0.599998 C=82 M=60 Y=31 K=19 PROCESS 100.000000 CMYK 81.800003 59.500004 30.700005 19.400002 C=88 M=20 Y=1 K=0 PROCESS 100.000000 CMYK 87.599998 19.900000 0.900000 0.000000 C=8 M=50 Y=78 K=1 PROCESS 100.000000 CMYK 7.800001 50.199997 78.000000 0.800002 C=14 M=9 Y=7 K=1 PROCESS 100.000000 CMYK 14.100003 9.299999 7.300001 0.599998 uuid:c3e92bc4-3674-4130-a152-9eb6eb3f4310 proof:pdf xmp.did:654B561D6FB5EE1194C1B9D66733FF64 uuid:47e446a5-e04b-4f08-b686-5e46c2bd4a48 uuid:fdfd9f6c-0dd9-499b-8d13-0646e9fbafa9 xmp.did:bbdd0f15-7727-9445-9ae9-b7aad7b48a68 uuid:47e446a5-e04b-4f08-b686-5e46c2bd4a48 proof:pdf saved xmp.iid:bbdd0f15-7727-9445-9ae9-b7aad7b48a68 2024-01-15T13:21:01+03:00 Adobe Illustrator 26.5 (Windows) / saved xmp.iid:654B561D6FB5EE1194C1B9D66733FF64 2024-01-19T11:35:45+05:00 Adobe Illustrator CS6 (Windows) / D:\РАБОТА\эндомед\Новая папка (2)\2э.psd adobe:docid:photoshop:162da0e1-7c79-d341-aed1-b3b779b4652d xmp.iid:de926e5d-ff27-5342-8a1f-7404d2df06fd D:\РАБОТА\эндомед\Новая папка (2)\1э.psd adobe:docid:photoshop:5627de46-4135-8e4c-8871-2055a0f9f334 xmp.iid:e50054ac-94f6-424b-a289-032129fa12c0 D:\РАБОТА\эндомед\Новая папка (2)\4э.psd adobe:docid:photoshop:ba2f7117-ed82-0140-9af4-397acd70b719 xmp.iid:ce34f2ef-78d6-164b-82db-b379c363c975 D:\РАБОТА\эндомед\Новая папка (2)\3э.psd adobe:docid:photoshop:9a95dc78-f03b-f74f-a282-9f42b858ff48 xmp.iid:9fa5ae95-4941-9744-8c01-9236a021bfe8 C:\Users\ainot\OneDrive\Рабочий стол\эндоскоп.psd adobe:docid:photoshop:6ba79c39-f1a4-3740-bce1-234bd464a7f8 xmp.iid:dd939d20-8fdb-934d-9d4a-8edcb4ff6741 Adobe Illustrator Document endstream endobj 3026 0 obj <> endobj 3027 0 obj <> endobj 3028 0 obj <> endobj 3029 0 obj <> endobj 3030 0 obj <> endobj 3031 0 obj <> endobj 3032 0 obj <> endobj 3033 0 obj [1.0 1.0 1.0 1.0] endobj 3034 0 obj <>/ProcSet[/PDF/ImageB]/XObject<>>>/Subtype/Form>>stream H 1 0 = oڤ.GNECe%objHϫ$ }qڤ[ruHsR&xiO5US endstream endobj 3035 0 obj <> endobj 3036 0 obj <>stream AdobedC     '$''''$25552;;;;;;;;;;   !"#$%&'()*123456789:ABCDEFGHIJQRSTUVWXYZabcdefghijqrstuvwxyz?ЪѪҪӪԪժ֪תЪѪҪӪԪժ֪ת endstream endobj 3037 0 obj <> endobj 3038 0 obj [1.0 1.0 1.0 1.0] endobj 3039 0 obj <>/ProcSet[/PDF/ImageB]/XObject<>>>/Subtype/Form>>stream H*w6PH/23355403W0B BLHT\!9K3@%+  endstream endobj 3040 0 obj <> endobj 3041 0 obj <>stream AdobedC     '$''''$25552;;;;;;;;;;   !"#$%&'()*123456789:ABCDEFGHIJQRSTUVWXYZabcdefghijqrstuvwxyz?ЪѪҪӪԪժ֪תЪѪҪӪԪժ֪ת endstream endobj 3042 0 obj <> endobj 3043 0 obj [1.0 1.0 1.0 1.0] endobj 3044 0 obj <>/ProcSet[/PDF/ImageB]/XObject<>>>/Subtype/Form>>stream H 1 0 = ҟI]GNECe=KdGgT0F\-Ctm|N*/7 0Cs endstream endobj 3045 0 obj <> endobj 3046 0 obj <>stream AdobedC     '$''''$25552;;;;;;;;;;6  ^C !"#$%&'()*123456789:ABCDEFGHIJQRSTUVWXYZabcdefghijqrstuvwxyz?ЪѪҪӪԪժ֪תЪѪҪӪԪժ֪תЪѪҪӪԪժ֪תЪѪҪӪԪժ֪ endstream endobj 3047 0 obj <> endobj 3048 0 obj [1.0 1.0 1.0 1.0] endobj 3049 0 obj <>/ProcSet[/PDF/ImageB]/XObject<>>>/Subtype/Form>>stream H*w6PH/23352241Q0B0PLRT\!9K3@%+ W endstream endobj 3050 0 obj <> endobj 3051 0 obj <> endobj 3052 0 obj [1.0 1.0 1.0 1.0] endobj 3053 0 obj <>/ProcSet[/PDF/ImageB]/XObject<>>>/Subtype/Form>>stream H*w6PH/231341634Q0BS# XA\(in`dighndjlb˥k`R endstream endobj 3054 0 obj <> endobj 3055 0 obj <>stream AdobedC    ' "'''''",////,7;;;7;;;;;;;;;; IC ^C !"#$%&'()*123456789:ABCDEFGHIJQRSTUVWXYZabcdefghijqrstuvwxyz?ЪѪҪӪԪժ֪תЪѪҪӪԪժ֪תЪѪҪӪԪժ֪תЪѪҪӪԪժ֪תЪѪҪӪԪժ֪תЪѪҪӪԪժ֪תЪѪҪӪԪժ֪תЪѪҪӪԪժ֪תЪѪҪӪԪժ֪תЪѪҪӪԪժ֪תЪѪҪӪԪժ֪תЪѪҪӪԪժ֪תЪѪҪӪԪժ֪תЪѪҪӪԪժ֪תЪѪҪӪԪժ֪תЪѪҪӪԪժ֪תЪѪҪӪԪժ֪תЪ endstream endobj 3056 0 obj <> endobj 3057 0 obj <>/Resources<>/Font<>/ProcSet[/PDF/Text]/Properties<>/XObject<>>>/Type/Page>> endobj 3058 0 obj <>/Resources<>>>/Type/Page>> endobj 3059 0 obj <> endobj 3060 0 obj <> endobj 3061 0 obj <> endobj 3062 0 obj <> endobj 3063 0 obj <> endobj 3064 0 obj <> endobj 3065 0 obj <> endobj xref 0 4 0000000000 65535 f 0008641549 00000 n 0008641677 00000 n 0008646619 00000 n 7 1 0008646712 00000 n 13 2 0008646806 00000 n 0008646933 00000 n 18 1 0008647055 00000 n 50 39 0008647177 00000 n 0008647290 00000 n 0008647759 00000 n 0008648329 00000 n 0008648809 00000 n 0008649276 00000 n 0008649743 00000 n 0008650210 00000 n 0008650678 00000 n 0008651145 00000 n 0008651627 00000 n 0008652096 00000 n 0008652565 00000 n 0008653135 00000 n 0008653614 00000 n 0008654081 00000 n 0008654535 00000 n 0008654990 00000 n 0008655444 00000 n 0008655924 00000 n 0008656419 00000 n 0008656888 00000 n 0008657357 00000 n 0008657927 00000 n 0008658406 00000 n 0008658926 00000 n 0008659436 00000 n 0008660016 00000 n 0008660597 00000 n 0008661051 00000 n 0008661546 00000 n 0008662015 00000 n 0008662582 00000 n 0008663061 00000 n 0008663572 00000 n 0008664152 00000 n 0008664685 00000 n 0008665167 00000 n 0008665664 00000 n 127 1 0008666060 00000 n 747 25 0008667207 00000 n 0008667689 00000 n 0008668187 00000 n 0008668672 00000 n 0008669246 00000 n 0008669727 00000 n 0008670238 00000 n 0008670750 00000 n 0008671243 00000 n 0008671740 00000 n 0008672212 00000 n 0008672796 00000 n 0008673296 00000 n 0008673808 00000 n 0008674343 00000 n 0008674824 00000 n 0008675307 00000 n 0008675891 00000 n 0008676384 00000 n 0008676864 00000 n 0008677387 00000 n 0008677843 00000 n 0008678311 00000 n 0008678791 00000 n 0008679287 00000 n 1164 25 0008679757 00000 n 0008680239 00000 n 0008680684 00000 n 0008681129 00000 n 0008681587 00000 n 0008682070 00000 n 0008682569 00000 n 0008683042 00000 n 0008683617 00000 n 0008684099 00000 n 0008684594 00000 n 0008685076 00000 n 0008685579 00000 n 0008686069 00000 n 0008686552 00000 n 0008687051 00000 n 0008687537 00000 n 0008688112 00000 n 0008688607 00000 n 0008689065 00000 n 0008689572 00000 n 0008690066 00000 n 0008690608 00000 n 0008691098 00000 n 0008691601 00000 n 1468 25 0008692059 00000 n 0008692574 00000 n 0008693088 00000 n 0008693578 00000 n 0008694067 00000 n 0008694549 00000 n 0008695034 00000 n 0008695608 00000 n 0008696076 00000 n 0008696533 00000 n 0008697027 00000 n 0008697484 00000 n 0008697940 00000 n 0008698422 00000 n 0008698920 00000 n 0008699392 00000 n 0008699966 00000 n 0008700447 00000 n 0008700949 00000 n 0008701464 00000 n 0008702005 00000 n 0008702511 00000 n 0008702980 00000 n 0008703478 00000 n 0008703963 00000 n 1824 25 0008704537 00000 n 0008705022 00000 n 0008705596 00000 n 0008706077 00000 n 0008706583 00000 n 0008707227 00000 n 0008707709 00000 n 0008708207 00000 n 0008708692 00000 n 0008709266 00000 n 0008709747 00000 n 0008710204 00000 n 0008710648 00000 n 0008711209 00000 n 0008711666 00000 n 0008712159 00000 n 0008712652 00000 n 0008713158 00000 n 0008713640 00000 n 0008714138 00000 n 0008714610 00000 n 0008715184 00000 n 0008715665 00000 n 0008716167 00000 n 0008716669 00000 n 2008 3 0008717184 00000 n 0008717420 00000 n 0008717660 00000 n 2021 1 0008717900 00000 n 2023 1 0008717929 00000 n 2025 1 0008717958 00000 n 2027 1 0008717987 00000 n 2050 1 0008718247 00000 n 2052 1 0008718845 00000 n 2098 25 0008719120 00000 n 0008719613 00000 n 0008720106 00000 n 0008720612 00000 n 0008721110 00000 n 0008721595 00000 n 0008722067 00000 n 0008722641 00000 n 0008723122 00000 n 0008723616 00000 n 0008724122 00000 n 0008724615 00000 n 0008725141 00000 n 0008725630 00000 n 0008726112 00000 n 0008726610 00000 n 0008727082 00000 n 0008727656 00000 n 0008728137 00000 n 0008728639 00000 n 0008729132 00000 n 0008729666 00000 n 0008730192 00000 n 0008730731 00000 n 0008731213 00000 n 2448 25 0008731711 00000 n 0008732173 00000 n 0008732635 00000 n 0008733044 00000 n 0008733453 00000 n 0008733922 00000 n 0008734395 00000 n 0008734868 00000 n 0008735341 00000 n 0008735814 00000 n 0008736400 00000 n 0008736881 00000 n 0008737350 00000 n 0008737852 00000 n 0008738345 00000 n 0008738858 00000 n 0008739371 00000 n 0008739864 00000 n 0008740333 00000 n 0008740831 00000 n 0008741316 00000 n 0008741903 00000 n 0008742384 00000 n 0008742890 00000 n 0008743383 00000 n 2743 323 0008743885 00000 n 0008744111 00000 n 0008744339 00000 n 0008744479 00000 n 0008744625 00000 n 0008744771 00000 n 0008744915 00000 n 0008745059 00000 n 0008745194 00000 n 0008745336 00000 n 0008745478 00000 n 0008746147 00000 n 0008746753 00000 n 0008747203 00000 n 0008747317 00000 n 0008747400 00000 n 0008747480 00000 n 0008747764 00000 n 0008748152 00000 n 0008765439 00000 n 0009418318 00000 n 0009418396 00000 n 0009565188 00000 n 0009565386 00000 n 0009565582 00000 n 0009565776 00000 n 0009565969 00000 n 0009566163 00000 n 0009566356 00000 n 0009566549 00000 n 0009566743 00000 n 0009566942 00000 n 0009567135 00000 n 0009567331 00000 n 0009567527 00000 n 0009567723 00000 n 0009567916 00000 n 0009568110 00000 n 0009568306 00000 n 0009568502 00000 n 0009568698 00000 n 0009568893 00000 n 0009569088 00000 n 0009569283 00000 n 0009569474 00000 n 0009569667 00000 n 0009569863 00000 n 0009570053 00000 n 0009570245 00000 n 0009570437 00000 n 0009570629 00000 n 0009570823 00000 n 0009571012 00000 n 0009571204 00000 n 0009571397 00000 n 0009571589 00000 n 0009571781 00000 n 0009571977 00000 n 0009572167 00000 n 0009572360 00000 n 0009572553 00000 n 0009572745 00000 n 0009572939 00000 n 0009573127 00000 n 0009573320 00000 n 0009573513 00000 n 0009573703 00000 n 0009573897 00000 n 0009574093 00000 n 0009574283 00000 n 0009574476 00000 n 0009574668 00000 n 0009574865 00000 n 0009575060 00000 n 0009575255 00000 n 0009575450 00000 n 0009575645 00000 n 0009575840 00000 n 0009576035 00000 n 0009576231 00000 n 0009576427 00000 n 0009576623 00000 n 0009576820 00000 n 0009577016 00000 n 0009577212 00000 n 0009577408 00000 n 0009577603 00000 n 0009577798 00000 n 0009577994 00000 n 0009578190 00000 n 0009578386 00000 n 0009578582 00000 n 0009578779 00000 n 0009578978 00000 n 0009579174 00000 n 0009579370 00000 n 0009579565 00000 n 0009579760 00000 n 0009579956 00000 n 0009580151 00000 n 0009580347 00000 n 0009580541 00000 n 0009580737 00000 n 0009580934 00000 n 0009581131 00000 n 0009581327 00000 n 0009581524 00000 n 0009581721 00000 n 0009581919 00000 n 0009582116 00000 n 0009582315 00000 n 0009582511 00000 n 0009582708 00000 n 0009582907 00000 n 0009583103 00000 n 0009583299 00000 n 0009583495 00000 n 0009583691 00000 n 0009583885 00000 n 0009584081 00000 n 0009584275 00000 n 0009584470 00000 n 0009584667 00000 n 0009584844 00000 n 0009584956 00000 n 0009585068 00000 n 0009585176 00000 n 0009585280 00000 n 0009585404 00000 n 0009585528 00000 n 0009585647 00000 n 0009585722 00000 n 0009585845 00000 n 0009585950 00000 n 0009586056 00000 n 0009586301 00000 n 0009586358 00000 n 0009586442 00000 n 0009586541 00000 n 0009586648 00000 n 0009586824 00000 n 0009586922 00000 n 0009587030 00000 n 0009587137 00000 n 0009587241 00000 n 0009587443 00000 n 0009587619 00000 n 0009587727 00000 n 0009587834 00000 n 0009587942 00000 n 0009588047 00000 n 0009588088 00000 n 0009625966 00000 n 0009626081 00000 n 0009626194 00000 n 0009626235 00000 n 0009634599 00000 n 0009634721 00000 n 0009635215 00000 n 0009644297 00000 n 0009644411 00000 n 0009644527 00000 n 0009644744 00000 n 0009644955 00000 n 0009645080 00000 n 0009645199 00000 n 0009645416 00000 n 0009645877 00000 n 0009646338 00000 n 0009745034 00000 n 0009823025 00000 n 0009823066 00000 n 0009862070 00000 n 0009862262 00000 n 0009862662 00000 n 0009863021 00000 n 0009864261 00000 n 0009864376 00000 n 0009864500 00000 n 0009864718 00000 n 0009864945 00000 n 0009964906 00000 n 0010064980 00000 n 0010065021 00000 n 0010104025 00000 n 0010126776 00000 n 0010165832 00000 n 0010166271 00000 n 0010167036 00000 n 0010212543 00000 n 0010226248 00000 n 0010239902 00000 n 0010250448 00000 n 0010253878 00000 n 0010257514 00000 n 0010257775 00000 n 0010261417 00000 n 0010261678 00000 n 0010267777 00000 n 0010267828 00000 n 0010267883 00000 n 0010267941 00000 n 0010268571 00000 n 0010268612 00000 n 0010269891 00000 n 0010270168 00000 n 0010270619 00000 n 0010271109 00000 n 0010274218 00000 n 0010274857 00000 n 0010275681 00000 n 0010276329 00000 n 0010280895 00000 n 0010280924 00000 n 0010281273 00000 n 0010281664 00000 n 0010281735 00000 n 0010282005 00000 n 0010282100 00000 n 0010302072 00000 n 0010302101 00000 n 0010302545 00000 n 0010302574 00000 n 0010303268 00000 n 0010303297 00000 n 0010303617 00000 n 0010303925 00000 n 0010303996 00000 n 0010304292 00000 n 0010304382 00000 n 0010314641 00000 n 0010314670 00000 n 0010315077 00000 n 0010315106 00000 n 0010315479 00000 n 0010315907 00000 n 0010315978 00000 n 0010316254 00000 n 0010316347 00000 n 0010340112 00000 n 0010340141 00000 n 0010340572 00000 n 0010340601 00000 n 0010341235 00000 n 0010341781 00000 n 0010341852 00000 n 0010342119 00000 n 0010342226 00000 n 0010371227 00000 n 0010371340 00000 n 0010371419 00000 n 0010371565 00000 n 0010371604 00000 n 0010371826 00000 n 0010590858 00000 n 0010590936 00000 n 0010662951 00000 n 0010666845 00000 n 0010687734 00000 n 0010691790 00000 n 0010696864 00000 n 0010697572 00000 n 0010698280 00000 n 0010699362 00000 n 0010700070 00000 n 0010706959 00000 n 0010707161 00000 n 0010707357 00000 n 0010707552 00000 n 0010707747 00000 n 0010707941 00000 n 0010708137 00000 n 0010708333 00000 n 0010708527 00000 n 0010708646 00000 n 0010708792 00000 n 0010708939 00000 n 0010709058 00000 n 0010709205 00000 n 0010709304 00000 n 0010709403 00000 n 0010709859 00000 n 0010709900 00000 n 0010729467 00000 n 0010729586 00000 n 0010729705 00000 n 0010729824 00000 n 0010729943 00000 n 0010730062 00000 n 0010730177 00000 n 0010730246 00000 n 0010730282 00000 n 0010730617 00000 n 0010730696 00000 n 0010731404 00000 n 0010731473 00000 n 0010731509 00000 n 0010731842 00000 n 0010731921 00000 n 0010732629 00000 n 0010732698 00000 n 0010732734 00000 n 0010733069 00000 n 0010733148 00000 n 0010734230 00000 n 0010734299 00000 n 0010734335 00000 n 0010734667 00000 n 0010734746 00000 n 0010734815 00000 n 0010734851 00000 n 0010735189 00000 n 0010735268 00000 n 0010742157 00000 n 0010742271 00000 n 0010742661 00000 n 0010742939 00000 n 0010742973 00000 n 0010743000 00000 n 0010743034 00000 n 0010743067 00000 n 0010743106 00000 n 0010743140 00000 n trailer <]/Prev 8586505>> startxref 10743179 %%